Protein: RDC1_METCM
Sequence: MKSHTSAAKVVFLVGDQVDSWHNGLQHVIKAAGATPWLQSYLDDLSNAIKAEIAEAALDNALHASLGTFSSLLELGERYRHRSDDLGMAQCLLLHAVRSSLFLQMAKQSAHILSPESQTEWLGISGGLISLSPRFVAEDFETLREASIEIGRLFVRLCKLVSVRSRAIEDNTGVWGWAILGVSKDEIRKGLDKFQQNMRIPAIKRAQVGVTGPGWSTIIGPPSVLDLCIKQCPAIATATKNPLNIHALQHTLAITQTDLNYIVGNSQLMSRALHHIRPRLWGMDDPEATYQNWGDMLRAICSQVLSLSLDIPEAVANLGASLRGCDSVQIIQMDNTSHGPFVSTALKAPGRKATLLETHSYLQTQFQGTEPPQKTGRIAIVGMSGRGPRSDNIDEFWDVIMQKQDTCTEVPKDRFDIDEFYCEEHGKGNKICTMTTKYGCFMDKPGHFDARFFHISPRESMLMDPGHRHFLMSSYEALEMAGYSDGPTKLTDPNRIAAFYGQVTDDWHDQSHPTLGCDAYTLQGVQRAFSSGRLAWQFKWEGPTYSLDSACASTTAAIHLACMSLLSNDIDMAVAGASNILNYPHSFACLSKSGVLSDTGNCKPYRDDADGYCRADFVGSVVLKRLEDAVADNDNILAVIASSGRNHSGNSTSITSSDPGAQERLFRKVLRNANVSPDDISYVEMHGTGTPVGDPAEMSAVGNVFKHRRRADGPLPVGAVKANFGHSEGAAGMASLLKCIMMFKTDTIPPQAGMPHALNPNFPPLSELNVEIPAEPKEFKKTRSGEPRRILLNNFDAAGGNACLLLEDWDGSHSPVAQLEDTTDTRSSHVVTLSSRTQAAHKANKQNFLNWLRENTTARLADIAYTTAARRMHHPIRSAYTASTTEELMARVEASIQVSESSSLTSQQTPIIFVFSGQGSHYAGMGSDLYQTSPSFRETVDLCGHIGKIHGFPPFIDLIADKAIDMSTKSTVQTQLAVLTLEIGLAAFWKAAGVQPSAVMGHSLGEYAALHVSGVLSLADVLYLVGQRASLLLERCEENGFAMLAVAMSAKETQELLDSNKEFPSCSIACFNGPNATVISGEAHDISQLQGRVSKASKVLPVPYGFHSFQMDSIISEYSTLADGVTFSEPKIPVASTLVGSMIETKDIINSVYLAQQTRQPVDFIGGLNAIQQMFNDPIWLEIGPNQVCTQFVRASSSSSSPNTKTLSTLEGQSRDWVAINKCMAMLYTQGIAIDWLALHKPFMNSLRMVTLPAYAWDTKDYWITYAEAKAVQGTTSSAPRDIKQPIISTFAQHVAKESSSNAGKLEITFRASVADQNLQAVMEGHRMEQLPICPGSGFCEAAFSAAAYVLESIGRKEDATVTKMRLQHPVMHRPLTKNLVGPDGELFTTITMESKDSNNIHVSWKASASGPKSSMFEMGTCTLVVQKNVKALQATWDRTAYLVRDRMDSIIKSAEDGQGHWLKHDIFYSLFATTVQYDPLYKCTKMAYISNDFSEAVAEVVLQDNPADAKFMASPYWGEGIVHIAGFVVNANPLRSPGTCFINSGFESFEQTVEFRAGKSYLAYARAHQVEEGRKICQVFVFDSEGKIVAQCYNLSFVRISNALLQHNLSEGASKPVGRGMAKQEKQEVPATTEVVRQPEKEESRHSVDTPSFSDVLINTIVSETGLDPSELTDDTVVAELGVDSIMSIEIANKVSNATGEQLTPMFLHEYPTIGDIKRAFDILTPVSSESDAELTEEYDLLEDTVTEEAVVHVPSPSSTSLEAVVTGSITTKQRDAPQQPRSIGDGPEPAVRFTLLHGRASKRVQDQQASPSPFYLIADGTGSIATYLHLPPHINTKMTIYGVDSPYLHCPSRLTPDVGIPGIAKLIVDELVKRQPQGVPFWLGGFSGGAMIAYEIARQLSALGHVIDSLLLIDMCPPRQIQAQRYDDELGLAMFDAISGNDDSGVWESSDKTHQHLKALFASVSAYNPPPLAKGESPPAKRVALIWAQKGMIDRCANSPRFRQILADRGLVTESYPGFMEDPKLGPVAWSLIHKTESDLGPNGWDKFVGRDELLCMAVEADHLELPTPEFVHLLGEKMDMAFEHFGR
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of radicicol, a resorcylic acid lactone (RAL) that irreversibly inhibits the HSP90 molecular chaperone, an important target for cancer chemotherapy (PubMed:18567690).  The radicicol cluster encodes only two apparent post-PKS enzymes, a cytochrome P450 monooxygenase (rdc4) and a non-heme halogenase (rdc2) that could introduce the epoxide and the chlorine, respectively.  If this cluster includes all the genes required for radicicol biosynthesis, the remaining structural features of radicicol are presumably generated by the PKSs rdc1 and rdc5.  The C-2' ketone could arise if the R-PKS rdc5 and NR-PKS rdc1 each carry out four iterations, in contrast to the five iteration-three iteration split for the hypothemycin PKSs.  The origin of the cis 5',6' double bond is not known.  The radicicol R-PKS rdc5 ER domain may catalyze either double bond isomerization or reduction in the third iteration (PubMed:18567690) (Probable).
What are the official names of this protein?
Non-reducing polyketide synthase rdc1, NR-PKS rdc1, Radicicol biosynthesis cluster protein rdc1.