PharMolix/UniProtQA huggingface dataset:
Protein: HCAB_ECO24
Sequence: MSDLHNESIFITGGGSGLGLALVERFIEEGAQVATLELSAAKVASLRQRFGEHILAVEGNVTCYADYQRAVDQILTRSGKLDCFIGNAGIWDHNASLVNTPAETLETGFHELFNVNVLGYLLGAKACAPALIASEGSMIFTLSNAAWYPGGGGPLYTASKHAATGLIRQLAYELAPKVRVNGVGPCGMASDLRGPQALGQSETSIMQSLTPEKIAAILPLQFFPQPADFTGPYVMLASRRNNRALSGVMINADAGLAIRGIRHVAAGLDL
What is the function of this protein?
Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.
What are the official names of this protein?
3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase, 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase, 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase, CI-dihydrodiol dehydrogenase, Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase, Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase, PP-dihydrodiol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: ISPE_STAAC
Sequence: MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKPPSAWVILAKPNLGISSPDIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGADGALMSGSGPTVYGLARKESQAKNIYNAVNGCCNEVYLVRLLG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
Putative 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RF2_TOLAT
Sequence: MFEVNPVLNKLKELSERTELLRGYLDYDAKKERLEEVSAELEQPEVWNEPERAQALGKERSALESVVATIDVLTQGAEDVEMLVSLAVEGEDEETFHEAETEADALEKKLVDLEFRRMFSGQHDASDCYMDIQSGSGGTEAQDWADMVLRMYLRWGEAHGYKPELIECSDGDVAGIKSATIKFTGEYAFGWLRTETGVHRLVRKSPFDSGGRRHTSFCSAFVYPEIDEDVEIEINPADLRIDVYRASGAGGQHVNRTESAVRITHIPTNTVTQCQNDRSQHKNKDQAMKQLKAKLYELEMMKQNAEKQALEETKSDIGWGSQIRSYVLDDSRIKDLRTGVETRNTQSVLDGDLDKFIEASLKSGL
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_POLNA
Sequence: MSTPVFTVADIRKTFLDFFAAKGHTVVPSSSLVPGNDPTLMFTNSGMVQFKDVFLGVDKRPYVRATSVQACLRAGGKHNDLENVGYTARHHTFFEMLGNWSFGDYFKRESLKWAWELLTEVYKLPAERLLATVYEEDDEAYDIWTKEIGLPPERVIRIGDNKGGRYKSDNFWMMADTGPCGPCSEIFYDHGDHIPGGPPGSPDEDGDRFIEIWNNVFMQFNMAEDGSVTPLPAPCVDTGMGLERLAAILQHVHSNYEIDIFDALIKAASRETGEADLGHKSLRVIADHIRATAFLVSDGVNPSNEGRGYVQRRIIRRAIRHGYLLGKKTPFFHKLVADLAGLMGDAYPRLAADAQRITEVLKAEEERFFETLETGMQILDAALADGVKVLPGEVAFKLHDTYGFPLDLSADVCRERGLSVDEAGFTVAMNQQKAQARAAGKFKMDRALDYSGTGNVFTGYEHLEETSKIIAIYADGVSAAALKAGQNGVIVLDTTPFYAESGGQAGDEGELISGSARFAVSDTLKIKADVYGHHGTLAEGTLNVGDHVSARVNKEVRAATVRNHSATHLMHKALREVLGAHVQQKGSLVNAERTRFDFAHNAPMTDAQIREVEARVNAEILANSATDASEMDMEAAQKTGAMMLFGEKYGDSVRVLSIGSSKELCGGTHVGRTGDIGLFKIVAESGVASGVRRVEAVTGQNALAYLQSLESTVQSAAGTLKASPSELQNRIGQVLDQVKALEKEVAALKGKLASSQGDELMLQAVDVKGLKVLAARLEGADAKTLRETMDKLKDKLKTAVIVLAAVDGSKVQIAAGVTSDSTGKVKAGELVNFVAGQVGGKGGGKADMAMAGGTDASNLNAALDSVLGWVSAKL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_BART1
Sequence: MHRYRSHHCAALRKCDVGTKVRLSGWVHRVRDHGGILFVDLRDHFGITQIVADPASPAFKVIEKVRSEWVIRVDGEVCARSDEVINATLPTGEIEIFVQEVEILSKSEELPLPVFGEPDYPEDIRLKYRFLDLRRETMHKNIMRRTEIIAAMRRAMQNNGFTEFSTPLLTASSPEGARDFLVPSRVHQGKFYALPQAPQQYKQLLMMSGFDRYFQIAPCFRDEDPRADRLPGEFYQLDVEMSFVEQEDVLATMEPIMRSIFEEFANGKTVTQNFPRISYDEAIQKYGSDKPDLRNPIIMEDVSQHFYNSGFKVFAQILADDENAQVWAIPAKTGGSRAFCDRMNVWAQGEGQPGLGYIFWRKEEEKFEGAGPIAKNIGEQRTEALRIQLGLENGDACFFVAGDPKKFASFAGAARTRVGEELDLVDRECFSLAWIVDFPFFEWNEDEKKIDFAHNPFSMPQGGENALECQDPLTLKAFQYDLVCNGYEIASGGIRNHLPEMMLKVFELVGLSKKVVKDRFGALYRAFHYGAPPHGGMAAGIDRIIMLLQGVKNLREVALFPMNQQALDLLMNAPSDVSSTQLRDLGIRMAPTQKNSS
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOKDC_SALTY
Sequence: MTDSIMQNYNQLREQVINGDRRFQHKDGHLCFEGVDLDALARQYPTPFYVFSEPEIIRNIHEIQQAFAAHKNTKTFFASKTCSVMGVLKAIRDAGICAEANSQYEVRKCLEIGFRGDQIVFNGVVKKPADLEYAIANDLYLINVDSLYELEHIDAISRKLKKVANVCVRVEPNVPSATHAELVTAFHAKSGLDLEQAEETCRRILAMPYVHLRGLHMHVGDQVPESEPFAKATKVLVDESRRLEEVLGIKFDLINVGGGIPVPYKYDDENGDPLKDNMYAGITAQDFADAVIREVHKWRTDVEICIEPGRKVTGSAAVLLTEVSCEKRKTNYDLNGNVECHVEWKFVDAGYSVLSDSQHFDWFFYVYNASRMTAAHDAWIKLAGPLCDGGDYFHMGVKGEEFLLPKETHVGDIVAFLDAGAYTIESQTVYNNRPRTGVVMIDKNGDTRLIRREDSYEDMVKYDIY
What is the function of this protein?
Catalyzes the decarboxylation of D-ornithine and D-lysine (PubMed:29024617, PubMed:30699288).  Ornithine is likely the physiological substrate (PubMed:29024617).  Has no detectable diaminopimelate decarboxylase activity in vitro (PubMed:29024617).
What are the official names of this protein?
D-ornithine/D-lysine decarboxylase, D-Orn/D-Lys decarboxylase, DOKDC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Protein: YABA_LISMO
Sequence: MDKKAIFDSVSNMEEQIGELYQQLGDLKTNLGEMLEENNRLNLENEHLRRRLSLTDEATPEPKAETEAEHGVMAPNRKEAMQQMIELGEGYDNLVQLYKEGFHVCNVHFGSPRGNDEDCLFCLSLLNKK
What is the function of this protein?
Involved in initiation control of chromosome replication.
What are the official names of this protein?
Initiation-control protein YabA.
What is the protein family that this protein belongs to?
Belongs to the YabA family.
Protein: QNG1_HUMAN
Sequence: MDGLLNPRESSKFIAENSRDVFIDSGGVRRVAELLLAKAAGPELRVEGWKALHELNPRAADEAAVNWVFVTDTLNFSFWSEQDEHKCVVRYRGKTYSGYWSLCAAVNRALDEGIPITSASYYATVTLDQVRNILRSDTDVSMPLVEERHRILNETGKILLEKFGGSFLNCVRESENSAQKLMHLVVESFPSYRDVTLFEGKRVSFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADYRLPQVLAHLGALKYSDDLLKKLLKGEMLSYGDRQEVEIRGCSLWCVELIRDCLLELIEQKGEKPNGEINSILLDYYLWDYAHDHREDMKGIPFHRIRCIYY
What is the function of this protein?
Function as a queuosine-5'-monophosphate hydrolase essential for salvage of the nucleobase queuine from exogenous queuosine, following its phosphorylation by a cellular kinase (PubMed:36610787).  Involved in salvaging queuosine (PubMed:15164053, PubMed:36610787).
What are the official names of this protein?
Q-nucleotide N-glycosylase 1, Queuosine salvage protein, Queuosine-nucleotide N-glycosylase/hydrolase.
What is the protein family that this protein belongs to?
Belongs to the queuosine salvage protein family.
Protein: CID11_ARATH
Sequence: MAVVETGAAATAADAGGVVIQPPPSSPPSSMTSQDSGVSSDDQNHHSRIDQVLRHDQGLYSKIGSHVARSDGVDGGESFKRDMRELQELFSKLNPMAEEFVPPSLNKQGGNGVNGGFFTSAGSFFRNNGFAGTGNGGYGNENGGFRRKKSFGQGKRRMNARTSMAQREDVIRRTVYVSDLDQQVTEEQLAGLFVSCGQVVDCRICGDPNSVLRFAFIEFTDEEGAMTALNLSGTMLGFYPVKVLPSKTAIAPVNPTFLPRTEDEREMCARTIYCTNIDKKVTQSDVKIFFESFCGEVYRLRLLGDYQHSTRIAFVEFVMAESAIAALNCSGVVLGSLPIRVSPSKTPVRPRSPRHPMH
What are the official names of this protein?
Polyadenylate-binding protein-interacting protein 11, PABP-interacting protein 11, Poly(A)-binding protein-interacting protein 11, PAM2-containing protein CID11, Protein CTC-INTERACTING DOMAIN 11.
What are the subcellular locations of this protein?
Nucleus.
Protein: PUR7_RICRS
Sequence: MKKKLYEGSSKILYSAEEDFLLIMAFSDKAILETGEIVDISGKGVLNNNISSFLMDKLEMIGIENHFIEKINMREQLIQYVEVFPIQVIISSVACSRFVKEFGIDEGYVFDKPIIDFKVRSREFKYPIVNEYQILNFGWLTRDEIKAVKEQALRIYDFLSGLFIGVGIRLVECKLEFGRVFNGEESIIMLTDEISPDNCRLWHINSNEKLGFELLEKEPNKVFESYQLIADRLKEK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: SCRK_PEDPE
Sequence: MLLGAIEAGGTKFVCATGAENGQVSDRISIPTTTPVETMTAVDDYFTTHPVDAIGIGSFGPIGVNPHDPKYGYITTTPKPGWGDFDFLGHLKSQFNIPLYWTTDVNEAAYGESMIGIAKDVPNSIYMTIGTGVGAGVISQNHIFNGRTHTELGHMRLNRLPGDDFKSNCPYHDICLEGLAAGPAVGKRTGKAGKDIPVDDPVWPIITDYIAQACVNLTVAFAPDKIILNGGVMNQRQLFPMIREKFAAYLNGYEEVPPLDDYIVPAGLGNNSGIAGGLLLAQAALKNA
What are the official names of this protein?
Fructokinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family.
Protein: RNZ_BACC0
Sequence: MEFVFLGTGAGVPSKGRNVSAIALQLLEERGQTWLFDCGEATQHQILHTSVRPRRIEKIFITHLHGDHIFGLPGLLGSRSFQGGTTPLTVYGPKGIKQFIEVALSVSTTHVKYPLEIVEITEEGTVFEDNEFHVETKRLSHGIECFGYRIIEKDIQGALLVDKLLEIGVKPGPLFKRLKDGEVVELENGTILNGNDFIGPPQKGRVITILGDTRYCEASRELAQDADVLVHEATFAAEDEQQAYDYFHSTSKQAASIALQANAKRLILTHISSRYQGDTYKELLKEARELFSNTEIATDLKSFPVDR
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: RBL_CUSRE
Sequence: MSPQTETKASVGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYRIERVIGEKDQYIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYTKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMLKRALFARELGVPIIMHDYLTGGFTANTSLAHYCRENGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRLSGGDHIHSGTVVGKLEGEREITLGFVDLLRDDFVEQDRSRGIYFPQDWVSLPGVMPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAQEGNDILRQAGKWSPELAAACEVWKEIRFDFKPVDTLDPNDKKQRDNEDTLADKLFGDKG
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid.
Protein: URM1_NEUCR
Sequence: MSDQKDQMIDITVDFSGGLEILFSNQKHHALSVPAQDAQGKPANVGFLINYLCQTLMTDPRADLFVLGGELRPGILCLINDCDWELEEEDAYVLQPGDNILFISTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog nit-1/uba4.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as ahp1.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGS_ASPFU
Sequence: MSLHTGWPRTVNSSFLKKHRSSLCTCQHTSSVLPRSFSTTPDRHVQQSADFSSTSRSYDRLGRRAREKLLDREFFLSLLSSATTKREAKSYLARLKAQHPKSPDANKPEPEKSATAPTLPSGVNLGSFYGASRSVYESPVFRQGPSPSAPPSLEPVERLHLALVRLSTPQSLDDNIIDGVAKTLSQLNRLGLTCCVVVDPGTEGVASALRQVAIEQADRLAVAIQKQPDSKSLRLDSVFSIDPSRPGLPQVFSRKALLNPLRHGHTVILTPIAYTEDVPRAIIVPANDAVIALTKELAGLASIPDPDEDPMVTAERIGRLQKEVSLDRVILLDPLGGIPAFNRRQPSHVFINMEQEYDDIENELLQAREMVPATETSLLKAGPNSVADNNPISKFVHAEVVPVPSGSTPELKTAVPQRSAIEGHLENLRVAQKALAMLPAASSGIITSPFEVASSAQTSPTSEFSAVGTRRQRNPLIHNLLTDKPLLSSSLPMSRRGPTNNGQGAVYPVTSHTTFVKRGMPLTMLPNPWTEPWTPQSRPRLKLDDPSIDLPRLVHLIEDSFDRKLDVQDYLNRVNDRLAGLIIAGEYEGGAILTWELPPGVEDDGSEASNARMVPYLDKFAVLKRSQGAGGVADIVFNAMVRSCFPNGVCWRSRKNNPVNKWYFERSLGTWKLSDTNWTMFWTTPGLVEDSQKFRDYEAVCRSIQPSWADDTGVVD
What is the function of this protein?
N-acetylglutamate synthase involved in arginine biosynthesis.
What are the official names of this protein?
Amino-acid acetyltransferase, mitochondrial, Arginine-requiring protein 2, Glutamate N-acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FLP1_SCHPO
Sequence: MDYQDDGLGEMIEFLEDKLYYTSLSQPPKAELYPHMHFFTIDDELIYNPFYHDFGPLNVSHLIRFAVIVHGIMGKHRQAKKSKAIVLYSSTDTRLRANAACLLACYMVLVQNWPPHLALAPLAQAEPPFLGFRDAGYAVSDYYITIQDCVYGLWRARESSILNIRNIDVHDYETYERVENGDFNWISPKFIAFASPIQAGWNHASTRPKKLPQPFAIVLDYFVANKVKLIVRLNGPLYDKKTFENVGIRHKEMYFEDGTVPELSLVKEFIDLTEEVEEDGVIAVHCKAGLGRTGCLIGAYLIYKHCFTANEVIAYMRIMRPGMVVGPQQHWLHINQVHFRAYFYEKAMGRAIQQATAAEPLATPPRHPLNATNGTSQSNISTPLPEPTPGQPRKVSGHNPPSARRLPSASSVKFNEKLKNASKQSIQNENKASYSSYEDSEIQNDDETRTVGTPTETISVVRLRRSSSQSNIEPNGVRSPTSSPTGSPIRRTSGNRWSSGSSHSKKSAQRSVSMSSLNNTSNGRVAKPKPSKSRLIS
What is the function of this protein?
Protein phosphatase which antagonizes mitotic cyclin-dependent kinase cdc2, the inactivation of which is essential for exit from mitosis.  To access its substrates, is released from nucleolar sequestration during mitosis.  Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint.  Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases.  Allows damaged actomyosin rings to be maintained to facilitate completion of cell division in response to minor perturbation of the cell division machinery.  Dephosphorylates the mitotic inducer cdc25 for its rapid degradation.  Down-regulation of cdc25 activity ensures a prompt inactivation of mitotic cdc2 complexes to trigger cell division.  Dephosphorylates also cdc2-phosphorylated nsk1, allowing nsk1-binding to kinetochores and spindle.  Dephosphorylates ase1, which is essential for spindle midzone assembly and for continuous extension of the anaphase spindle.  Tethered to the contractile ring by mid1, where it dephosphorylates cdc15.
What are the official names of this protein?
Tyrosine-protein phosphatase CDC14 homolog, CDC fourteen-like phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cell septum. Note=Localizes to kinetochores in prometaphase. Cytoplasmic retention is mediated through the binding of rad24. Tethered to the contractile ring by mid1.
Protein: CIF_YERPY
Sequence: MKISPNTISPSQSDPRMSTNVSQRSRVSGIGVPVSHSINNPSIQHVQDFATLSARSLRANVLLNSDDHSVPIHAKNPSELLEAIDNNISQTAQDWGVSIQEVEVILGSSKRIIEPVCGVTANTIMKLFLDNDIFSYSFEKGQSLSLSQLQERLASLPAHKNFILRVNDGGLGHAYVIDFPATTNPSRDAFLYQSDLGEGVTREVRFEDWMTQKASHPISLDDINTHFIGIAQDQIDLAHIAKLFDVDGNVKMLRADHLISHKTSEFNFQLFEYDLKNLENNMSIIKTHCN
What is the function of this protein?
Protein-glutamine deamidase effector that inhibits the host cell cycle and other key cellular processes such as the actin network and programmed-cell death (PubMed:19308257, PubMed:22691497).  Acts by mediating the side chain deamidation of 'Gln-40' of host NEDD8, converting it to glutamate, thereby abolishing the activity of cullin-RING-based E3 ubiquitin-protein ligase complexes (CRL complexes) (PubMed:22691497).  Inactivation of CRL complexes prevents ubiquitination and subsequent degradation of the cyclin-dependent kinase inhibitors CDKN1A/p21 and CDKN1B/p27, leading to G1 and G2 cell cycle arrests in host cells (PubMed:19308257).  Also able to catalyze deamidation of 'Gln-40' of host ubiquitin in vitro; however, NEDD8 constitutes the preferred substrate in vivo (By similarity).
What are the official names of this protein?
Protein-glutamine deamidase Cif, Cycle-inhibiting factor homolog, CHYP.
What is the protein family that this protein belongs to?
Belongs to the Cif family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Note=Secreted via the type III secretion system (TTSS).
Protein: D2HDH_PSEPK
Sequence: MIAQLSTVAPSANYPEFLEALRNSGFRGQISADYATRTVLATDNSIYQRLPQAAVFPLDADDVARVATLMGEPRFQQVKLTPRGGGTGTNGQSLTDGIVVDLSRHMNNILEINVEERWVRVQAGTVKDQLNAALKPHGLFFAPELSTSNRATVGGMINTDASGQGSCTYGKTRDHVLELHSVLLGGERLHSLPIDDAALEQACAAPGRVGEVYRMAREIQETQAELIETTFPKLNRCLTGYDLAHLRDEQGRFNLNSVLCGAEGSLGYVVEAKLNVLPIPKYAVLVNVRYTSFMDALRDANALMAHKPLSIETVDSKVLMLAMKDIVWHSVAEYFPADPERPTLGINLVEFCGDEPAEVNAKVQAFIQHLQSDTSVERLGHTLAEGAEAVTRVYTMRKRSVGLLGNVEGEVRPQPFVEDTAVPPEQLADYIADFRALLDGYGLAYGMFGHVDAGVLHVRPALDMKDPVQAALVKPISDAVAALTKRYGGLLWGEHGKGLRSEYVPEYFGELYPALQRLKGAFDPHNQLNPGKICTPLGSAEGLTPVDGVTLRGDLDRTIDERVWQDFPSAVHCNGNGACYNYDPNDAMCPSWKATRERQHSPKGRASLMREWLRLQGEANIDVLAAARNKVSWLKGLPARLRNNRARNQGQEDFSHEVYDAMAGCLACKSCAGQCPIKVNVPDFRSRFLELYHGRYQRPLRDYLIGSLEFTIPYLAHAPGLYNAVMGSKWVSQLLADKVGMVDSPLISRFNFQATLTRCRVGMATVPALRELTPAQRERSIVLVQDAFTRYFETPLLSAFIDLAHRLGHRVFLAPYSANGKPLHVQGFLGAFAKAAIRNATQLKALADCGVPLVGLDPAMTLVYRQEYQKVPGLEGCPKVLLPQEWLMDVLPEQAPAAPGSFRLMAHCTEKTNVPASTRQWEQVFARLGLKLVTEATGCCGMSGTYGHEARNQETSRTIFEQSWATKLDKDGEPLATGYSCRSQVKRMTERKMRHPLEVVLQYAQR
What is the function of this protein?
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HGA) to 2-oxoglutarate (Probable).  Is involved in a D-lysine catabolic pathway (PubMed:31064836).
What are the official names of this protein?
D-2-hydroxyglutarate dehydrogenase, D2HGDH.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FAD-binding oxidoreductase/transferase type 4 family.
Protein: EFTS_LEPIN
Sequence: MAAVTTDLIRELRERTSAGMMDCKKALEENNADIEKAITWLREKGIAKAAKKAGRETKEGRVVSYIHGNGKIGVLVELNSETDFVSKNEDFEALGKEICMQIAAMNPLYLNEESIPAADLEKEKTIMRSQLEAEGKKADQIEKILPGKIKKYVSEVCLVNQAFFKDDSKTIDDLVKEAIAKFGENITIARFIRFQVGGL
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJKA_SCHPO
Sequence: MCASVTESLPKFPELKTRDLQGQQGPIRSLGWNLSGSRLASSSSSGSVLVWNSDRLDFKFTTELGNRGYGLVEQLVWDPTHSDRLMAVYAGKMIRFWDFRSAKPIAEIESNYENIYATWSPSGNYCCASSRDDMLSFIDARERRIMETFQQPCETNECCWSFSEDLFFMTTGLGTVQIMEWPSLKRVYDIKAHNSNCFCIEFSPDNRHLAIGGADAITSLWDPQELICERSITRMDYPIRTLSFSYDSRYLASGSEDRYVDIADTKTGDQIWKIPTNGPLNKVAWHPTKHILAYAVSEPNSSGLKIFGL
What are the official names of this protein?
Uncharacterized WD repeat-containing protein C18B5.10c.
Protein: PGLX_ECOHS
Sequence: MNTNNIKKYAPQARNDFRDAVIQKLTTLGIAADKKGNLQIAEAETIGETVRYGQFDYPLSTLPRRERLVKRAREQGFEVLVEHCAYTWFNRLCAIRYMELHGYLDHGFRMLSHPETPTAFEVLDHVPEVAEALLPESKAQLVEMKLSGNQDEALYRELLLGQCHALHHAMPFLFEAVDDEAELLLPDNLTRTDSILRGLVDDIPEEDWEQVEVIGWLYQFYISEKKDAVIGKVVKSEDIPAATQLFTPNWIVQYLVQNSVGRQWLQTYPDSPLKDKMEYYIEPAEQTPEVQAQLAAITPASIEPESIKVLDPACGSGHILTEAYNVLKAIYEERGYRTRDIPQLILENNIFGLDIDDRAAQLSGFAMLMLARQDDRRILGRGVRLNIVSLQESKLDIAEVWTKLNFHQHMQRGSMGDMFTQGTALANTDSAEYKLLMRTLALFTSAKTLGSLIQVPQEDEAALKAFLERLYRLAVEGDIQQKEAAAELIPYIQQAWILAQRYDAVVANPPYMGGKGMNGDLKEFAKKQFPDSKSDLFAMFMQHAFSLLKENGFNAQVNMQSWMFLSSYEALRGWLLDNKTFITMAHLGARAFGQISGEVVQTTAWVIKNNHSGFYKPVFFRLVDDNEEHKKNNLLNRMNCFKNTLQNDFKKIPGSPIAYWATLAFINSFLKLPALGTRAVKGLDTNGSIDVFLRRWPEVSINSFDALGKGNSKWFPIAKGGELRKWFGNHEYIINYENDGIELRKNKANLRNKDMYFQEGGTWTVVSTTGFSMRYMPKGFLFDQGGSAVFCENNDELSIYNILACMNSKYINYSASLICPTLNFTTGDVRKFPVIKNNHLEDLAKKAIEISKADWNQFETSWEFSKNKLIEHKGNVAYSYASYCNFQDKLYEQLVNIEKNINNIIEEILGFKIETTENSELITLNSNKIYRYGQSETNDTFLNRHRSDTISELISYSVGCQMGRYSLDREGLVYAHEGNKGFAELAAEGAYKTFPADNDGILPLMDDEWFEDDVTSRVKEFVRTVWGEEHLQENLEFIAESLCLYAIKPKKGESALETIRRYLSTQFWKDHMKMYKKRPIYWLFSSGKEKAFECLVYLHRYNDATLSRMRTEYVVPLLARYQANIDRLNDQLDEASGGEATRLKRERDSLIKKFSELRSYDDRLRHYADMRISIDLDDGVKVNYGKFGDLLADVKAITGNAPEAI
What is the function of this protein?
Methylates the adenine in the fifth position of the hexamer 5'-GGTAAG-3' in genomic DNA; methylates the same sequence in the few phage that escape the BREX system.  Methylated phage are now resistant to BREX, showing immunity is provided by an epigenetic modification.  Expression of this protein alone has no effect on phage infection, does not lead to methylated DNA and mildly inhibits growth.
What are the official names of this protein?
Adenine-specific methyltransferase BrxX, BREX protein PglX.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PglX adenine methyltransferase family.
Protein: Y1124_THESQ
Sequence: MKRIVVVSGLSGAGKTTAMGFLEDLGYFCVDNVPGNILEELLKLFMSSDLEKMAMAIDVRSEHLGDPISAVERIKEKTNTLVIFLEASTEELLRRYALTRRRHPLQKDGIGLEDAIEKERKILSRIKEIADVVIDTTSMNTHQLRETLTHFLVNQSGGTSVRIMSFGFKHGIPMDADFVFDARFLPNPHYVPELSSKTGLDSKVEAYFKNYPVVEEFIEKIYEVLKVAIEEYQRTGRRIVTVGIGCTGGKHRSVYIAHRLKEMLEKEGFTVIEKHRDIEKV
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein TRQ2_1124.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: SEC11_AJECG
Sequence: MLSSLSPYMANPRNTLSQVLNFGLVLSSAFMVWKALSVITNSASPVVVVLSGSMEPAFQRGDLLFLWNRSPRVDVGEIVVYNVQGKDIPIVHRVMRVFPDVPTTGGEDVEGVEASQKLLTKGDNNLSDDTELYAPGQEFLDRKTDLMGSVRGYVPAIGYVTIMLSEHPWLKSVLLGFMGLMVMLQRE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: RS15_RUEPO
Sequence: MSITTEEKARVMKEYGTKDGDTGSPEVQVAILSSRIATLTEHFKTHKKDNHGRRGLLKLVAQRRKLLDYLKAKDEARYQSLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.