Protein: PRKDC_DICDI
Sequence: MDNIYQRIENYLIKLFQTISETNNNNNNNNTNNNVGIKFENDLLLVNELGSIILKELVLEEEIGLVASLLFTGDHSLLKYLEKSSTISNKENVKIKVSILNLIAEFIEILQVRTDDYAIAIKNTCVLVFRKDQSHSVQAAAFGPIKKILHLMSRVLKQGSIVAESFGVSEMTQLFLLQFTCGKLTQTVRGEIIVVLGLFTEYFSSNMCDRNQQLSFIFMETLGGQLRSKSPESTLIQSCLKGLNSLLVHFSGDFIASDPKNVQLIYQYVYICLDPASSTQRFEIPRAAMKIVARHAVLLRQYLAEHSQPFYTRIEHWCNHINKLNRDIAFTAVDSFFQQISKELTSGNRSLEADQSTFKFFIRKFYSIFENNNSSRFELSIAIRGCGRFASPVKSFMGEWELKSLLNSLFKFSEKLMVVKIENIDEITLHLSSFINAFACILYELNELEFWYLDHIEQVLETYFIIFPHLFVKSRDRYFKAVNRLISSLFYHGEYLKILLSRFVKKGLLITFSKPNDSIKNLITTANTPFYQVYKDLWYNLLNPTIDTIDKDLNSTIKKENNNNNNNKNKNNNNNQTLTKEEISKSIKKLVYDEIVSSILSIIKKLDLQYQKDENDNNSNSNSNNNNNNDQDNNKISIIEYESEINQLKPVTSKDIELFLGLVEFFKLFISKYNTELFVQWIYIFGKEMISFSKKYPLISGFYKLVQIVMQICKSQKYFNELQQDDNINSVIFNNQIIDEQLQQQQDIMDIDDTDNNSNSNNKINKKLTNSLEEDKNNCFILFKKYIKEVSNFISHYKDELLSSCIELLLSLPKQLISIPLLVPIANLAFQYGISYLPLAHVGLNAIEYWNLVVPDQVHKHLDQLLPSLNDYLKISTNSSDSTSGGDIDIDSGGSMGGGGVVPPPSSSSRHRKMKFKSNSSLIDPKQLQFKTSIEDLQNRIIRLLGQLGGDNVHFLGKVSLVGEEIVNGVAWDTEPKVLIKIPFADQNNIDIYLDVILPNVVNLAEKSPNRQIKVAAGELLHSVLLMMIGNSANQSQANQISYSRLYRKIFPSLICLSTDVEQVTKQLFQPLVFQMIHWFTRNKKQESDDTMNLLNAIVDAVGNPLDGARRDFAGQCLCEFAKWSLKNTSVKQQEKNAFNFKSILKRIYSLAHHPDPYKRLGAAISFNQLYRIFREEDSLVDQFIFEILHNIFFSLRIGDDLTNTSSSKNNSNSNSNNNNNNNNNSEDGTEDSIVEIASKYSNVLAALTKVIIKRADMLNKPSNTRREHKDLSQFVQWVFQNGCSRTESIVRYESMILFTQLVTLLPNIKTPLQWVKERIKSNGIQFIVSIAEQQGGGVGGGSSNGNTSLGRIPKIEIGKHKDIEFWFRNLSTSLNIYLWFFSEGFFEPIQILTSREFKSSLLSSAFHTFTTQFSMLNFNSNLKTNQQQQQQQVSMFSSMTPKEIDQFNRLKCNVITNLFGLYILLLEKYKFEQVIDYGGVAFVQLLVKCLMDPQSVGFVNNYLEEREVELSKSSRQDIRNLMSRTFKFPPLLEIINNIIKLLIQIKPKYNDILHKELMEYILPNNSNNNNNSSSSGNNKSMFSLIDIRQLINTEGTDRLIHLIHSYQILYKYNLLDSILLENYNEQSEQGIQDLPKSSLEFSEFIFDYLFNNCENLSPSKLLISKELIQLALTIGIKPIKLLSLIINPNVQNTTTTTTTTSTTTTTTTTTTSTNNNNDNNNEFIKDIHDIFYKTLFTEINNYISNNFQLFLPLLANRIIETNQIHKVLNDVCIMKQQQQPNRGFKDIIESIVLFLNSISEWTLNSNLKLVEKENIIEFTKNLIKIDPIQFFENKHCYEFVYNIITNYLCRSNPLTFKNKVLVLLPYLLSYPKHNNFDLIKQKLNEIVVYDFPLNSKDLTVKSPIYNEYITCIERLLETFELTKNPLVIDTLLHVLKETDHTHINYINLSIERSILSTNDIEAKEIFSHCFELFLNHYDELKITLIDKFCVPLISHMKENILVQIFSQHLSSLMSIIQPLQPKYLSDSQERKSSIIEKICCFHLIEALYQSLPSAIIKEKINPFFYDKPDGKGTELTAAIMKAAHSAKSEKLTSDDKYVTRSLCTKYHGAAFSALASVIVSTQTKENFFHVFFFKENKDKNEYLWENIIDTDQVFNFQPETNFLVSYSTPQSLFANDLRYLSSQYLVDSSLSQDFIAKNFLEGDNNSTTNNNNGDDGIIMQGQSQSGDNENQISNDIEIDQVNSNPSMIAMLKIIDFYQKKFVVTPPSSILFGQQSQQPKPTVGDMPKWMFEIYQKLQQGVHPNIVIFMIKIIINRPQYFERFHELWIPILMDYVVSEGNGGNGLHYFVRDVCFILLKWPNIYKSQDGGGGTTLEKHLSKFVNHLMKNTYCTDRRILKSNLNIVKSFVERWKSLFKVDKSIILELLSTKGDFKSKSRQIKTTGLVLLSILLSNGYPAYDKEYDSNTISEFKFYQVLLDHLQDFKELYDAASEVCGMILLYLSKQQQSQQQQQQSIFPQLLKDKINSILNNNENQRAFSCLYFIGLHYPLFLQGFYGKIFNLLPQISNETRLIALNIIHWCVEDIQDLYTKLKSNNIENLIRIREGEIQVVILRILYKLVQKRDTTFGTVNQILSLLLSNNWFTSNVTNEYSRSLYYDIIIYIYNNFIEYQDQSNENSKDLVLSLLIGLSDESDSINKKLLQFWDNNSKTLSASSNQRLQQFFDIMYSPETESKWVANSCCLLFQLCNRSSDFTKLLFDKPLSECTFKEVQVDSSWQHRTLNMNPLFSSSQYGIDDATTDESNGDSMQLDEIRATQAPNFTLTQTAFSEFYPSSSQSYGGTNNNTGSSQLSSSSSSSGSQSSSQNNSSSKRKQKITNDPKLINNSELRRRFKKIDDRGADERIVKFARLQVKRNIEREAYFEKSKQARENQITMIRKYRVGELPDIQIKLQDIIKPLQLLCQRDSTIGVNVFSSLFTALYKNTPKESIRTFQCNIKKLIDSIVERCKFNSTLVSSILNISEKNLEFSPEFSKIKDISLNSNNHPMAIILCEKLILSLQNTTKASTTNQAQKLQQQQQLNQGWDSLRELYKSLKEDDIIMGLIEKQMGGDIPYTKKALEFELKGDWVNVLKVYDEATSKLESGELNQYQGNLSESETALWENGRLECFTKLCNWSALKDNFNSYYPNPNQIFKEKNCDLLLSYFFEFNLKVKENWNYLYQFIADLANTKQYQYLENKFPGELAFLEVTRSDHNKASYYVSKFYQAFKHQWSSSHPLAIESRHRILQPLQKIVEVEEFLNLTSTPIINTLKLDTLLTQWKSRFPTKLDDIMVWDDLIFYRSVLLEKIYERFSSFTSDKSSDEKVKSTLIQERAILYHKMSKGARKLGNIVVSEIYFRQAVKSYPKTKDNDLAFPLVTSLIDIYCTKARNSPSPIETLDRFVKALKFIESKKDEESIINSNENLQKYLMMHGDIFWDIYQLDKKLGSTLVIDSFKKNSLPINLTSIPINSLKDELFNSTFKCYSESIKLHQKSTNLLNTTSSSPSLSISSSSSPYSSTSSSSQPKLSNEILIEKTKTKSAHLKFANFCDNILKDKISQQTTPTQFNEEVIDLATSVIVSTLEAIKEEIPGSVDKFPRLLEILTQFEQYSVIAREFKSRVSTIPCWMFIRWISQMFPYLDLPQGPLILPILLEIAKWYPQAIYFPFKISSEQFGPLAKKISAPLEKELINPLLDTLVIEFQRLTHPEHRFKDYMEEMKSLIKATPKDLNAIAKLNNEIYDDSFNPSTVSGDYNLKFAKEHEASYLSNFGKDSTKLARMDQKKFLEIFAEMSGNMNKNMKPNSTASMKLKDFSGWLADFDRSNYQTSHQMEIPGQYDGIGKPQPETHVTISSFDTNVLVMGSLRKPKRVKIHGNDELDYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREILEEQLAHQLKTPRSNVSISKLESTKYHNDWINSFAKYLKPNSPVGPLYQQMFIHATRDDCAKKLEKQHSKVPENLLQNGIWSLSSSPESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPELMPFRLTRQFTSFLRPLDSVGLLNHNMTYTLTALQNQKEILLTTMDVFVKEPLLDWSKLATRLVKEQGKHPKDTKNVWFPKQKIQIAKKKLELVNPAYITLEELSGSVHSGLPYEKALSEIIKGDPKHNIRAKVNKVCSSVKEQIDCLIDQSTDPNILSRAWVGWNGAL
What is the function of this protein?
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage.  Is recruited to DNA ends by the Ku70/Ku80 heterodimer and is involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (By similarity).  This activity is only apparent when DNA damage is administered in G1 phase of the cell cycle.  Required for efficient signaling of DNA double-stranded breaks via phosphorylation of H2AX during G1.
What are the official names of this protein?
DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, DNA-PKcs.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. DNAPK subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.