PharMolix/UniProtQA huggingface dataset:
Protein: LECF_ASPFM
Sequence: MSTPGAQQVLFRTGIAAVNSTNHLRVYFQDVYGSIRESLYEGSWANGTEKNVIGNAKLGSPVAATSKELKHIRVYTLTEGNTLQEFAYDSGTGWYNGGLGGAKFQVAPYSRIAAVFLAGTDALQLRIYAQKPDNTIQEYMWNGDGWKEGTNLGGALPGTGIGATSFRYTDYNGPSIRIWFQTDLKLVQRAYDPHKGWYPDLVTIFDRAPPRTAIAATSFGAGNSSIYMRIYFVNSDNTIWQVCWDHGKGYHDKGTITPVIQGSEVAIISWGSFANNGPDLRLYFQNGTYISAVSEWVWNRAHGSQLGRSALPPA
What is the function of this protein?
Multispecific lectin that is able to recognize L-fucose in all possible linkages (PubMed:23695231).  These could be found not only in decomposed plant matter in soil, which is the natural environment for A. fumigatus, but also in various epitopes on human tissues (By similarity).  Mediates binding of A. fumigatus conidia to airway mucin in a fucose dependent manner (By similarity).  Stimulates IL-8 production by human bronchial cells in a dose-dependent manner, contributing to the inflammatory response observed upon the exposure of a patient to A. fumigatus, and thus might be an important virulence factor involved in an early stage of A. fumigatus infection (By similarity).
What are the official names of this protein?
Fucose-specific lectin, Aspergillus fumigatus lectin, AFL.
What is the protein family that this protein belongs to?
Belongs to the fungal fucose-specific lectin family.
Protein: CYF_LEPVR
Sequence: MQTRNTFSWIREEITRSISVSLMIYIITWASISSAYPIFAQQNYENPREATGRIVCANCHLANKPVDIEVPQTVLPDTVFEAVVKIPYDMQLKQVLANGKKGALNVGAVLILPEGFELAPPDRISPEMKEKIGNLSFQNYRPNKKNILVIGPVPGQKYSEITFPILAPDPATNKDVHFLKYPIYVGGNRGRGQIYPDGSKSNNTVYNATAGGIISKILRKEKGGYEITIVDASNERQVIDIIPRGLELLVSEGESIKLDQPLTSNPNVGGFGQGDAEIVLQDPLRVQGLLFFLGSVVLAQIFLVLKKKQFEKVQLSEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RHG26_XENTR
Sequence: MGLPPLEFSDCYLDSPQFRERLKSHEIELDKTNKFIKELIKDGKSLVAAHKNLSCAKRKFAGSLNEFKFRCIGDAETDDEICIARSLQEFAAVLGNLEDERIRMIDNSGEVLISPLEKFRKEQVGAAKEVKKKYDKESEKYCAMLEKHMNLSSKKKEVLLHEADVQLDQMRQHFYEVSLEYVLKVHEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFSDFKTQLSISIQNTRDRFEGTRSEVESLMKKMKENPHEHLALSPYTMEGYLYVQEKRHFGTSWVKHYCTYQRETKQMTMVPFDQKSGGKVGEEEIIHLKSCIRRKTESIEKRFCFDVEGVDRPTVLTMQALSEEDRKLWMEAMDGREPVYNSNKDSQSEGTAQLDNIGFSIIRKCIQAVETRGINEQGLYRIVGVNSRVQKLLNFLMDPKISPETETEIPSEWEIKTITSSLKTYLRMLPGPLMTYQFQRSFIKAAKLENQESRIKEIHCLIHRLPEKNRQMLNLLMTHLANVAAHHKQNLMTVANLGIVFGPTLLRPQEETVAAIMDIKFQNIVVEIIIENYEKMFSTVPEMPQTNSQLHLSRKRSSDSKPPSCSERPLTLFHTTHNTEKEEKRNSVNSSAESVSSSNANSSANSTCTQCSNMNNLNASDPDLDVAKASRPNSLSLNPSPTSPPTCPMFSAPSSPMPTSSTSSDSSPVSVPRKAKALYACKAEHDSELSFSAGTVFDNVYPSQEPGWLEGILNGKTGLIPENYVEFL
What is the function of this protein?
GTPase-activating protein for rhoa and cdc42.
What are the official names of this protein?
Rho GTPase-activating protein 26, Rho-type GTPase-activating protein 26.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers and cortical actin structures.
Protein: GPMA_BACCN
Sequence: MIKLVLIRHGQSLWNLENRFTGWTDVDLSENGLHEARTAGAILKKNGYTFDVAYTSVLKRAIRTLWIILHEMDLAWVPVHKSWKLNERHYGALQGLNKDETAKKYGEEQVHIWRRSTNVRPPALAEDDPRYEVTDPRYKRLKKGEFPLTECLEDTEKRVLEFWHKEIAPMLCSNQKVIISSHGNTIRSLVKYLDHLSDDGVVSLNIPTGIPLVYELDEHLHPIRHYYLNMDGEVQEGVIPKHISF
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: MURG3_BACCR
Sequence: MSKTILFTGGGTAGHVMINIVLIPKFIEKGWRVEYIGSKNGIEKSLVQNVKYNSVSTGKLRRYWDWDNFKDPFKIIRGCLQSYNLIKKTKPDVIFSAGGFVSVPVAIGAWLNRVPIIIREPDSTLGLANKIALPFATKLCTTFPQTGENVSNEKKVYVGPIVRVEIEKGNVLRGRRYCEFQQDKPVLLIMGGSQGAKWINDMVRECLDTILLNFNIIHICGKGKVDPSIGMEGYMQFEYIGDELPHILNMASVVVSRAGSTAISELLFLKKPMLLIPLTNSSSRGDQVLNAEYFSRQGYAEVILQDRVSTNTFIHAVNKLYTNKEKYIQNMNGYKKTNDEGIHQIIDIINEVVK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 3, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ALMA_ACIAD
Sequence: MEKHIDILIVGAGISGIGIAAHLSKDAPQRQFEIIERRENIGGTWDLFRYPGIRSDSDMSTFGFNFKPWQSPNVLASGSSIKGYLSEVVDEYDLKKKIHFKHRVLAANYDTASKKWYVEIEDAAQKKQTWIANFIVGCTGYYNYDQGFEPDFPNKDAFKGQFIHPQHWPENLDYVGKKVVIIGSGATAITLVPAMSKGGAEHVTMLQRSPTYIASIPSIDFVYDKMRKVLPEDLAYKLTRARNIGVQRGIYTLSQKQPKLVRKFLLKSIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGDLFKILRSGQASVETDQIEKFTETGIQLKSGKHLDADIVVSATGLEIQILGGIKGTIDGQPLDTSKSMLYQGVMVSDVPNMAMIIGYINASWTLKVDVAADYICRLLNYMDKQGYDEVIPEGDQTELMEDTVMGSLTSGYIARAANVMPKQGKHAPWKVTNNYLADRKALKNARFDDGVLHFDKKTDTVERKTKPKLVS
What is the function of this protein?
Is able to catalyze the degradation of n-alkanes with C chain lengths of 32 and 36.  Probably allows Acinetobacter baylyi strain ADP1 to grow on the long-chain n-alkane dotriacontane (C32H66) as a sole carbon source.
What are the official names of this protein?
Probable FAD-binding monooxygenase AlmA.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL34_THESM
Sequence: MKTMHRSRSWRRKYVRTPGGRTVIHFERKKPKVAHCAMCGRPLNGIPRGRPNELRKLPKTKKRPERPMPNLCPSCMRRIMKAQARATL
What are the official names of this protein?
50S ribosomal protein L34e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL34 family.
Protein: COBT_VIBA3
Sequence: MLDTQYSQYIQHRIDQKTKPLGALGLLEKVAHQLALIQSQGKETAVEHIELNKPRIIIFAGDHGIADEGVSIAPSAVTQQMVLNFLSGGAAINCFCAVNNVEITVVDTGILLPVESDSDMLISQRLGTRTNNFANEAAMSLETVERGIELGTELVSRTISNGTNIIMFGEMGIGNTSSASAILSALANRTADECVGLGTGINNEQLARKVAVVKQGIARCINPDAKEVLSQVGGYEIVQMVGGFLGAYENRTPVLVDGFIVSVAAYVATLIEPSCRDYMIFAHRSEESGHKILLELLDAEPLLDLGLRLGEGTGAALAMPIIRAAAEFYNNMASFASAGVTV
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: MIAB_FRATT
Sequence: MKEQKKVFIKTLGCQMNEYDSARMHEVLNEHFDTVKTDDYKDADIILINTCSIREKAQEKVFHELGRWKGLKKTNEDLIIGVGGCVASQEGENIIKRAPFVDLVFGPQTIHRLPEMIKQKQKTQQSQVDISFPEVEKFDYLPEPKAEGAKAYVSIMEGCDKYCSYCVVPYTRGPEVNRPFEDVLAECAILAEQGVKEITLLGQNVNHYLGPMENGQTADLALLIHFIAEIDGIERIRFTTSHPVEFSQNLIDAYATVPELANHLHLPVQHGSDRILINMKRNHTILEFKQKIRKLRAIRPDITISSDFIVGFPGETEEDFQKLLDLVKEINFDQSFSFIYSKRPGTPAADLPDDTPMEVKKDRLKRLQDLLNSNAQIISRQMVGTNQRILVDGTSKKDDNILSGRTENNRVVNFKGDKSLIGQFAMVKITESLPNSLRGELI
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATC_BRUMA
Sequence: MNLSTIGFQVIFKQRLRCVRFGVRCISRETLGCNSVAASSADEDDKIYVPKKPILSPIDQSKVEEPPVFDKALITHLERLSLVWFTDEQAVFNLKEAVRFANQLKLVDTTGIEPLETLLEDMPCPLREDVADNPMTKAEVLMNAAKVVEDYFVAPLENIPLEESDKLNLTKVEEFDRRVMAKKNLLNDSVKEKTE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial, Glu-AdT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SNMP1_BOMMO
Sequence: MQLAKPLKYAAISGIVAFVGLMFGWVIFPAILKSQLKKEMALSKKTDVRKMWEKIPFALDFKIYLFNYTNAEDVQKGAVPIVKEVGPFYFEEWKEKVEVEENEGNDTINYKKIDVFLFKPELSGPGLTGEEVIVMPNIFMMAMALTVYREKPAMLNVAAKAINGIFDSPSDVFMRVKALDILFRGIIINCDRTEFAPKAACTTIKKEAPNGIVFEPNNQLRFSLFGVRNNSVDPHVVTVKRGVQNVMDVGRVVAIDGKTKMNVWRDSCNEYQGTDGTVFPPFLTHKDRLQSFSGDLCRSFKPWFQKKTSYNGIKTNRYVANIGDFANDPELQCYCDSPDKCPPKGLMDLYKCIKAPMFVSMPHYLEGDPELLKNVKGLNPNAKEHGIEIDFEPISGTPMVAKQRIQFNIQLLKSEKMDLLKDLPGTIVPLFWIEEGLSLNKTFVKMLKSQLFIPKRVVSVVCWCMISFGSLGVIAAVIFHFKGDIMHLAVAGDNSVSKIKPENDENKEVGVMGQNQEPAKVM
What is the function of this protein?
Plays an olfactory role that is not restricted to pheromone sensitivity.
What are the official names of this protein?
Sensory neuron membrane protein 1, SNMP1-Bmor.
What is the protein family that this protein belongs to?
Belongs to the CD36 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GHRB_SALTY
Sequence: MKPSIILYKTLPDDLLHRLEAHFTVTQVPNLHPETVAQHAQAFASAQGLLGASETVNRALLEKMPALRAASTISVGYDNVEVDALTARKIVLMHTPAVLTETVADTVMALMLATARRVVDVAERVKAGEWTESIGPAWFGVDVHHKTLGIVGMGRIGMALAQRAHFGFTMPVLYHARRRHQEAEDRFNARYCDLDTLLQEADFVCVILPLTAETRHLFGATQFARMKSSAIFINAGRGPVVDENALIAALQNGEIYAAGLDVFEQEPLSVDSPLLNMSNVVAVPHIGSATHETRYNMMACAVDNLIDALQGKIEKNCVNPQAAG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_NEIG2
Sequence: MGIEGVLKKGFITTSADTVLNYMRTGSLWPVTFGLACCAVEMMHAGMARYDLDRFGIIFRPSPRQADLMIVAGTLTNKMAPALRRVYDQLAEPRWVLSMGSCANGGGYYHYSYSVVRGADRVVPVDVYVPGCPPTAEALIYGLIQLQQKIKRTSTIARDE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PCKA_THET2
Sequence: MQRLEALGIHPKKRVFWNTVSPVLVEHTLLRGEGLLAHHGPLVVDTTPYTGRSPKDKFVVREPEVEGEIWWGEVNQPFAPEAFEALYQRVVQYLSERDLYVQDLYAGADRRYRLAVRVVTESPWHALFARNMFILPRRFGNDDEVEAFVPGFTVVHAPYFQADPERDGTRSEVFVGISFQRRLVLIVGTKYAGEIKKSIFTVMNYLMPKRGVFPMHASANVGKEGDVAVFFGLSGTGKTTLSTDPDRPLIGDDEHGWSEDGVFNFEGGCYAKVIRLSPEHEPLIYKASNQFEAILENVVVNPESRRVQWDDDSKTENTRSSYPIAHLKNVVESGVAGHPRAIFFLSADAYGVLPPIARLSPEEAMYYFLSGYTARVAGTERGVTEPRATFSACFGAPFLPMHPGVYARMLGEKIRKHAPRVYLVNTGWTGGPYGVGYRFPLPVTRALLKAALSGALENVPYRRDPVFGFEVPLEAPGVPQELLNPRETWADKEAYDQQARKLARLFQENFQKYASGVAKEVAEAGPRTE
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPI_BUXMI
Sequence: MSVLPCSINTLKVLYDISGVEVGQHFYWQIGGFQVHAQVLITSWVVIAILLGSATIAVRNPQTIPTDGQNFFEYVLEFIRDLSKTQIGEEYGPWVPFIGTMFLFIFVSNWSGALLPWKIIQLPHGELAAPTNDINTTVALALLTSVAYFYAGLTKKGLGYFGKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPSVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: KAD_NEIME
Sequence: MKALLLGAPGAGKGTQAQFITAAFGIPQISTGDMLRAAIKAGTPLGLEAKKIIDEGGLVRDDIIIGMVKERIAQDDCKNGFLFDGFPRTLAQAEAMVEAGVDLDAVVEIDVPDSVIVDRMSGRRVHLASGRTYHVTYNPPKVEGKDDVTGEDLIQRDDDKEETVKKRLAVYHEQTEVLVDFYSKLEGEHAPKYIKVDGTQPVEAVKAEVLGALGK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLE_HALRO
Sequence: ADFSDDRITECQEAFELFDRSAEGKVFLGQVGDILRALGQNPTNGDVTKVLGNPPKEELATKQVSFSEFLPMLAQIERQTEHGSYEDFVEGLRVFDKENNGKIMGAELRHVLSTLGEKMSEEEVEESLLQGQQDPNGCIHYEEFSKYLLEG
What is the function of this protein?
In molluscan muscle, calcium regulation is associated with myosin rather than with actin.  Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.
What are the official names of this protein?
Myosin catalytic light chain, smooth muscle.
Protein: QUEF_XANOP
Sequence: MNTPEDSTLGREVAYPSGYDPSLLFPIPRAAGREAIGLTGALPFTGRDRWHAYELSWLDAHGKPCVATATLHVPHDSPALIESKSLKLYLNSLNATRFNSAEAVRTRIVTDLSTRAGADVSVEFGLPPIDGVGDGESIDALDVSIDDYGPPNAAYLTAQAQPVVEEVLTSALLKSNCPVTGQPDWASVTLHYRGAPIEREGLLRYLVSFRDHAEFHEQCVERIFHDVLLRCAPEWLVVEARYTRRGGLDINPLRSSLSVPAPLSVFRDLRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPPH_BARQU
Sequence: MDTDINLKNLPYRRCVGVVVFNHEGKVWVGRRLTKYAHADTEMSHRWQLPQGGIDEGEEPLDAACRELYEETGIRSIKLIKEARDWFYYDFPQKLVGCTLKNKYRGQIQKWFAFQFTGKLSEIATNPPPDDNKAEFDQWKWVDLEALPSIVISFKKHVYRKVVSEFRGSFRCL
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: STR4_STRTC
Sequence: MGASHSTVSDPHRFAVAITGSDDDVRSLQAHPTKSYDYIVVGGGTAGCVLASRLSEDSRVNVLLVEAGYSNHGVTNSIIPLAFPMLMKSKYDWNYETVGMAGINGRTSYWPRGRLLGGTSSINGSMYHRCAPEDFSAWVEEGAKGWEYENMKPYFRKAEGYNPHPDHPNIDPALHGTVGPAKVTHGPIAFLSQPITKDILQSSINVGIRQVHDFNTDVGPTGVGLFARNVFPNGTRVSAATGYLTPSVLARPNLTVAVECMAEKIVLSSDEKVPRAKGLIFSTSRDGQRFYVPASKELILSSGVIGTPQVLMLSGIGPAAELAKHNIPVVRDLPVGEYLQDHFSPGPMLIRAKKGTWDFILRPLGGLLAMVKWFFFGKGPLSSLSVQVACFVRSDDKTFAHPQLPMHDGAKKYQVKDCCSGPTAPDIELFFAPFLAPPLGMKYWPFPGLTSGMLLLKPASYGTVKLASRNAWDYPLIDPNYLSHESDIALSIMGMRLLARIARTKPFADSLDLPEDSDDKTSVFWPTDCNPDTVSDDDLEAWARLHGQSTGHPTSSARMGGSPSTSVVDSKLKVHGVEGLRVCDASCFPTQVSGHPAAVVVAVAERAADLIKGVA
What is the function of this protein?
Dehydrogenase; part of the gene cluster that mediates the biosynthesis of strobilurin A, an antifungal polyketide that contains a key beta-methoxyacrylate toxophore that targets the complex III of the mitochondrial electron transport chain (PubMed:30258052).  Strobilurin biosynthesis begins with construction of benzoyl CoA by step-wise elimination of ammonia from phenylalanine by the phenylalanine ammonia-lyase str11, oxygenation by str8 and retro-Claisen reaction to form benzoic acid, which is activated to its CoA thiolester benzoyl CoA by the dedicated CoA ligase str10 (PubMed:30258052).  Benzoyl CoA forms the starter unit for the highly reducing polyketide synthase stpks1 that produces the polyketide prestrobilutin A (PubMed:30258052).  The FAD-dependent oxygenase str9 then catalyzes the key oxidative rearrangement responsible for the creation of the beta-methoxyacrylate toxophore (PubMed:30258052).  Str9 performs epoxidation of the 2,3 olefin of prestrobilutin A, followed by Meinwald rearrangement to furnish the aldehyde intermediate (Probable).  Rapid enolization of the aldehyde intermediate would give the beta-methoxyacrylate skeleton and methylations catalyzed by str2 and str3 complete the synthesis and lead to the production of strobilurin A (Probable).  The short-chain dehydrogenase stl2 and the dehydrogenase str4 play a role in the shunt pathway leading to the production of bolineol (PubMed:30258052).  The cluster encodes no obvious halogenase gene that could be involved in production of strobilurin B, nor any obvious dimethylallyl-transferase that could be involved in the production of strobilurin G (Probable).  It is possible that unknown proteins encoded in, or near, the cluster (such as str1 or stl1) may form new classes of halogenases or dimethylally-transferases, or that the responsible genes are located elsewhere on the genome (Probable).  Similarly, proteins encoded by str5/str6 hydrolases appear to have no chemical role in the biosynthesis of strobilurin A (Probable).  Finally, no obvious self-resistance gene is found within the cluster (Probable).
What are the official names of this protein?
Dehydrogenase str4, Strobilurin A biosynthesis cluster protein r4.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: STRBP_BOVIN
Sequence: MRSIRSFANDDRHVMVKHSTIYPSPEELEAVQNMVSTVECALKHVSDWLDETSKGTKAEGETEVKKEEAVDTYSKDQGGRTLCGVMRIGLVAKGLLIKDDMDLELVLMCKDKPTETLLNTVKDNLPIQIQKLTEEKYQVEQCVDEASIIIRNTKEPTLTLKVILTSPLIRDELEKKDGEKVAMKDPPDLLDRQKCLNALASLRHAKWFQARANGLKSCVIVLRILRDLCNRVPTWAPLKGWPLELICEKSIGTCNRPLGAGEALRRVMECLASGILLPGGPGLHDPCERDPTDALSYMTIQQKEDITHSAQHALRLSAFGQIYKVLEMDPLPSSKPFQKYSWSVTDKEGAGSSALKRPFEDGLGDDKDPNKKMKRNLRKILDSKAIDLMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASGPSKKTAKLHVAVKVLQAMGYPTGFDADIECMSSDEKSDNEGKNETVSSNSSNNTGNSTTETSSTLEVRTQGPILTASGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNKKVAKASAALAALEKLFSGPNAANNKKKKIIPQAKGVVNTAVSAAVQAVRGRGRGTLTRGAFVGATAAPGYIAPGYGTPYGYSTAAPAYGLPKRMVLLPVMKFPTYPVPHYSFF
What is the function of this protein?
Involved in spermatogenesis and sperm function.  Plays a role in regulation of cell growth.  Binds to double-stranded DNA and RNA.  Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA.  Binds also to single-stranded poly(G) RNA.  Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).
What are the official names of this protein?
Spermatid perinuclear RNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm. Note=Microtubule- associated that localizes to the manchette in developing spermatids.
Protein: DNJB4_BOVIN
Sequence: MGKDYYCILGIEKGASDEDIKKAYRKQALRFHPDKNKSPQAEERFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDSDEMEVDGDPFGAFGFSMNGYPRDRNSVGPSRLKQDPPVIHELRVSLEEIYSGCTKRMKISRKRLNPDGRSYRTEDKILTIEIKKGWKEGTKITFPREGDETPTSIPADIVFVIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTMDGRTIPMTINDIVKPGMRRRIIGYGLPFPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHLPAS
What is the function of this protein?
Probable chaperone.  Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).
What are the official names of this protein?
DnaJ homolog subfamily B member 4.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane.
Protein: OXLA_BOTAL
Sequence: ADVRNPLEEFRETDYEVL
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:15142548).  Is highly active on L-Phe > L-Tyr > L-Met > L-Leu, and is weakly or not active on other amino acids (PubMed:15142548).  Exhibits diverse biological activities, such as slight hemorrhage, induction of platelet aggregation, edema in the mouse paw and bactericidal activity against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria (PubMed:15142548).  May also induce hemolysis, apoptosis of vascular endothelial cells or tumor cell lines, and may have antiparasitic activities (By similarity).  Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation.  These different effects are probably due to different experimental conditions.
What are the official names of this protein?
L-amino-acid oxidase, Balt-LAAO-I, LAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRM51_PHATC
Sequence: MLDPVEASSVPVVDDSTIRSLSDFPDRNVFRREDRYPALNIPVRRTAELRKTLKHVLWRRPKTKNVYDDETDPQRRILVLANIDEDAFRDETVQRLIQHEDCRKASYTVTTAYENYTVEEILKQLLPNESEIPSAFEMVGHLAHVNLRSSQLPFKYWIGKVMLDKNQPRIRTVVNKLGTIETEYRTFGMEVIAGYQGENWSVVTVKEERCTFRLDFTKVYWNSRLAGEHRRLVQQILKESQTKPLVVADLMAGVGPFAVPLTASHGRRNQVTVYANDLNPESYKYLLQNVQSNKCTNIHCYNQCGRAMVHQLQAENIEVDHVIMNLPASAPEFLDAFRGYEGVKRPCIHVHCFAPKASEATDYQDALDRCSSALGCTLDRISNDVHVHVVRDVSPNKNMLSVSFLLPVETQSLVKMKLQPLRTETSEPGAKRIKSN
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase 1, M1G-methyltransferase 1, tRNA [GM37] methyltransferase 1, tRNA methyltransferase 5 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.