PharMolix/UniProtQA huggingface dataset:
Protein: PAN3_EMENI
Sequence: MASVGKPSLEDARRGTGSPKMKARENAKDTLCRNVTIYGRCRYEDKGCAFNHDPHKNSNQSDNASKKRFNVDSPSFTPSLLPSNGSSPTSSSSSLKKSSTISPKAANAAPFQPRTAASRSNTSTPGVRQDAVAPDWSVAEAQEFIPQGFDPTHMSPLHGNGNPGVASANAFDPFVSTPNPLAAPGAVGPVQANPFSHDAAAATLGGAYYANQAGFQQPVQYHLYAPIGPHNQNALAYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQVDYFHSLVPLDLNHQKNAAIFGYPSWVYKAQSTKDGSYYALRRLEGFRLTNEKAIRSVQAWKRIASGSMVTIHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLSAGGPRFQARHNAHVPEQILWGYITQIANALKCIHSAGLAARIIDPSKILLTGRNRIRLNACAIMDVVQYDAQRSVADLQRQDLVNFGQLILTLGANQPNVIHNPSKAMEHFTRAYSPQLKNTVMWLLGGMQKDQERNIDILINGISSQLMSTFDSALHLDDQLTSDLGRELENGRLVRLLTKLNFINERPEHEHDRQWSENGERFYLKIFRDYVFHQVDASGDPVVDLGHVLTCLNKLDAGTDERITLVSRDEQTCFVVSYKELKKGLESSFQALLRPSRRPH
What is the function of this protein?
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.  pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex subunit pan3, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. PAN3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQO4_STAEQ
Sequence: MAMSDKKDVVLIGAGVLSTTFGSMLKTIAPDWDIHLYERLDRPGIESSNERNNAGTGHAALCELNYTVQQPDGSIDIEKAKEINEQFEISKQFWGHLVKSGEIQNPKEFINPLPHISFVRGKNNVKFLKDRYEAMKQFPMFDNIEYTEDIEEMRKWIPLMMKGREDKGYMAASKIDEGTDVNYGELTRKMAQNLKNSPNVEVQYKHEVVDFERLSNGKWSVKIKNLNNGQVFEHQTDYVFIGAGGGAIPLLQKTGIPESKHLGGFPISGQFIACTNPQVIEQHDAKVYGKEPPGTPPMTVPHLDTRYIDGERTLLFGPFANVGPKFLKHGSNLDLFKSIKPYNITTLLASAVKNLPLIKYSFDQVIMTKEGCMNHLRTFYPEARDEDWQVYTAGKRVQVIKDTEENGKGFIQFGTEVVNSEDHSVIALLGESPGASTSVSVALEVLEKNFPEYAKNWEPKIKKMIPSYGESLIDDVQLMRKIRKQTSKDLELGFYDKAK
What are the official names of this protein?
Probable malate:quinone oxidoreductase 4, MQO 4, Malate dehydrogenase [quinone] 4.
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: FEN1_CRYNB
Sequence: MGIKGLTGLLSENAPKCMKDHEMKTLFGRKVAIDASMSIYQFLIAVRQQDGQMLMNESGDVTSHLMGFFYRTIRMVDHGIKPCYIFDGKPPELKGSVLAKRFARREEAKEGEEEAKETGTAEDVDKLARRQVRVTREHNEECKKLLSLMGIPVVTAPGEAEAQCAELARAGKVYAAGSEDMDTLTFNSPILLRHLTFSEAKKMPISEIHLDVALRDLEMSMDQFIELCILLGCDYLEPCKGIGPKTALKLMREHGTLGKVVEHIRGKMAEKAEEIKAAADEEAEAEAEAEKYDSDPESEEGGETMINSDGEEVPAPSKLKSPKKKAPAKKKKVASSGMQIPEFWPWEEAKQLFMKPDVVNGDDLVLEWKQPDTEGLVEFLCRDKGFNEDRVRAGAAKLSKMLAAKQQGRLDGFFTVKPKEPAAKDTGKGKGKATKGEKRKAEEKGSAKKKSKN
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: Y2452_MYCLE
Sequence: MSSPLSPLYVLPFVDHTKWTRWRSLISLQAYSNLFGRTSAMQPDVAAGDEAWGDVLTLSPDADTADMHAQFICHGQFAEFVQPSNTSSNLEPWRPVVDDSEIFAAGCHPGISEGIQQADEGPR
What are the official names of this protein?
Uncharacterized protein ML2452.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv0477.
Protein: GPMB_SHIB3
Sequence: MLQVYLVRHGETQWNAERRIQGQSDSPLTAKGEQQAMQVATRAKELGITHIISSDLGRTRRTAEIIAQACGCDIIFDSRLRELNMGVLEKRHIDSLTEEEENWRRQLVNGTVDGRIPEGESMQELSDRVNAALESCRDLPQGSRPLLVSHGIALGCLVSTILGLPAWAARRLRLRNCSISRVDYQESLWLASGWVVETAGDISHLDAPALDELQR
What are the official names of this protein?
Probable phosphoglycerate mutase GpmB, PGAM, Phosphoglyceromutase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. GpmB subfamily.
Protein: RSMG_PHOPR
Sequence: MKQRLVQLIAQTELQVTEQQVQQLVGYVELLHKWNKAYNLTSVRDPNEMLVKHIMDSIVVSAHLQGENFIDVGTGPGLPGIPLAIMCPEKNFTLLDSLGKRIRFIKQVVHELKIANVTPVQSRVEEFQPEQGFDGVISRAFASMNDMVSWCHHLPAENGHFLALKGQFSEQEVAELPEWCSVTEVKPLQIPELEGKRHLVILTAKK
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_CLOBB
Sequence: MKSLLDSLNFPKDLNNLNDSDTERLSKEIRQFLIESVSKTGGHLSSNLGVVELTLSLMKSFDFEKDKIVWDVGHQSYVYKILTGRKDGFKNLRQFDGLSGFPKRNESKYDYFDTGHSSTSISAGLGMARARDLKKEKYTVVSVIGDGALTGGMALEALNDVGFRKTKMVIILNDNQMSISLNVGGLSRYLNKLRMGETYNRLKTNINTSLGSSDLGKDIISKMSKVKDSIKQLVVPSMFFENMGVKYIGPIDGHDIKAMNEVFSKVKDVEGPVIIHTVTQKGRGYSLAEKSPSKYHAVPPRANEKEKPSKPCKDTYSKAFGNALINIAKEEKEVVAITAAMPDGTGLKEFSTIYPERFFDVGIAEQHAVTLAAGMAANGLKPVFAVYSTFLQRGFDQVIHDVCIQDLPVTFAIDRAGIVGDDGETHQGIMDVSYLSMMPNMTIVAPKCTEEIPSMLRWAIKKNSPVAIRYPRGKDIVCNLHALQEISYGKWEVVSEGKRICIIASGRMLQHAFLAKEILKENGIDPKIVNATFIKPIDKCLLENLKEDGYDILTIEDNIICGGLGMAVLEHLNCIDYKGNMKLLGYDDEFIPQGNVEILYKTYGLDPVSISNTILKLYN
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: RPOC2_CERDE
Sequence: MEVLMAERADLVFHNKAIDGTAMKRLISRLIDHFGMAYTSHILDQVKTLGFQQATATSISLGIDDLLTIPSKGWLVQDAEQQSLTLEKNHHYGNVHAVEKLRQSIEIWYATSEYLRQEMNPNFRMTDPSNPVHIMSFSGARGNASQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVVRRTDCGTIRRISVSPQNGMTEKIFIQTLIGRVLADDIYIGPRCIATRNQDIGIGLINRFITFRAQPIYIRTPFTCRSTSWICRLCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEHVRAPSNGKIKFNEDLVHPTRTRHGHPAFLCYIDLYVTIESQSIIHNVNIPPKSLILVQNDQYVESEQVIAEIRTGASTFHFKERVRKHIYSDSQGEMHWSTDVYHAPEYTYGNVHLLPKTSHLWILSGGPCRSSIVPFSIQKDQDQINVNSLFVEQRYISDLSVTNDRVRHKIFSSDPSGQKGGRIFDYDSGPDRIVSNSQFLYPAIPHENSDLLAKRRRNRFLIPFQYDQEQEKELMCPYGISTEIPINGILRRNSILAYFDDPRYRRSSSGITKYATIEVDSIVKKEDLIEYRGSKEFRPKYQTKVDRFFFIPEEVHILPGSSSIMVRNNSIIGVDTRITLNIRSRVGGLVRVERKKKRIELKIFSGDIHFPGETDKISRHSGILIPPGVVKKNSKKSKKKWKNWIYIQRITPTKKKYFVSVRPVVTYEIADGINLPTLFPQDLLQERDNMQLQVVNYIISGNGKPSRGIPQTSIQLVRTCLVLNWDQDLKGSLEEIHASFVEVRTNDLIRDFIRIDLVKSPISYTGKRNDTWGSGLNPDSISDCTNINPFYSKARLPSFTQPKGTVRTLRNKEYQSLIILSSSDCYQIGPFKDSKYNKTTNCHNITKELIKEDSPVPISNSLGPLGAVPKFLNFDSFSHLITHNQILLKKYLLLDNLKHTSQVMKYFLLDENGKIHNTDPCRNIFFNPSHLNWYSLHHDFFYETPITISLGQFICENVYIFEYGPHIKSGQVLIVQFDSLVIRSAKPHLATPGATVHGHYGEILYEGDTLVTFIYEKSRSGDITQGLPKVEQVLEVRSIDSISLNLEKRVEGWNERVTRILGIPWGFLIGAELTIAQSCISLVNKIQKVYRSQGVQIHNRHIEIVVRQITSKVLVSEDGMSNVFSPGELIGLLRAERTGRALEEAIRYRAILVGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVLGGMIPVGTGFKGLVHHSRQHNNIPLEIKKRNLFEFEGEMGDILFHHRQSFGSCIQKTFHETSEQSFGFGRFNDS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TUSB_YERE8
Sequence: MLFTVSHSPYHCDLSALLRLVTSEDAILFLQDGVMAVLKNSESLNLLLNNQASLFVLEDDVIARGLCGQISDSAMLIGYTHFVDLTLKHQQQLAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXR_BURCH
Sequence: MQKRLTLLGSTGSIGDSTLDVVARHPERFSVYALTAHRNGDKLVEQCLRFAPEVAVVGDAATAAHVDAKLRAAGSKTVVLHGPQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKRILLANKEALVMSGAIFMDAVRDHGAILLPVDSEHNAIFQCMPRDAAEHGGISKIILTASGGPFRTREPATLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWIFGLPGDRIDVLIHPQSVIHSLVSYRDGSVLAQLGNPDMRTPIAHALAFPERVDAGVDQLDLAQIAQLSFEKPDYARFPCLALALKALEEGGIASAALNAANEVAVEAFLERRIGFMAIAATVDAVLNTLPNRAPDGLDDVLAADAEARRLAAAIIAKAPAPRVERTV
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: GS18_BACSU
Sequence: MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVKGKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFAICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIPAFNRESLALLEK
What is the function of this protein?
Functions in the protection against aldehyde-stress, possibly by degrading damaged proteins.
What are the official names of this protein?
General stress protein 18, GSP18.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family.
Protein: GHRB_ECO7I
Sequence: MKPSVILYKALPDDLLQRLQEHFTVHQVANLSPQTVEQNAAIFAEAEGLLGSNENVDAVLLEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARRVVEVAERVKAGEWTASIGPDWYGTDVHHKTLGIVGMGRIGMALAQRAHFGFNMPILYNARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMKSSAIFINAGRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIGSATHETRYGMAACAVDNLIDALQGKVEKNCVNPHVAD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYTB_STRR6
Sequence: MKKVRFIFLALLFFLASPEGAMASDGTWQGKQYLKEDGSQAANEWVFDTHYQSWFYIKADANYAENEWLKQGDDYFYLKSGGYMAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWVYDSQYDAWFYIKADGQHAEKEWLQIKGKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFYIKENGNYADKEWIFENGHYYYLKSGGYMAANEWIWDKESWFYLKFDGKIAEKEWVYDSHSQAWYYFKSGGYMAANEWIWDKESWFYLKFDGKMAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFYLKSDGKIAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFYLKSDGKMAEKEWVYDSHSQAWYYFKSGGYMAKNETVDGYQLGSDGKWLGGKATNKNAAYYQVVPVTANVYDSDGEKLSYISQGSVVWLDKDRKSDDKRLAITISGLSGYMKTEDLQALDASKDFIPYYESDGHRFYHYVAQNASIPVASHLSDMEVGKKYYSADGLHFDGFKLENPFLFKDLTEATNYSAEELDKVFSLLNINNSLLENKGATFKEAEEHYHINALYLLAHSALESNWGRSKIAKDKNNFFGITAYDTTPYLSAKTFDDVDKGILGATKWIKENYIDRGRTFLGNKASGMNVEYASDPYWGEKIASVMMKINEKLGGKD
What is the function of this protein?
Plays an important role in cell wall degradation and cell separation.
What are the official names of this protein?
Putative endo-beta-N-acetylglucosaminidase, Murein hydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 73 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YIDE_ECOK1
Sequence: MSDIALTVSILALVAVVGLFIGNVKFRGVGLGIGGVLFGGIIVGHFVSQAGMTLSSDMLHVIQEFGLILFVYTIGIQVGPGFFASLRVSGLRLNLFAVLIVIIGGLVTAILHKLFDIPLPVVLGIFSGAVTNTPALGAGQQILRDLGTPMAMVDQMGMSYAMAYPFGICGILFTMWMLRVIFRVNVETEAQQHESTRTNGGALIRTINIRVENPNLHNLAIKDVPILNGDKVICSRLKREETLKVPSPETVIQLGDLLHLVGQPADLHNAQLVIGQEVDTSLSTKGTDLRVARVVVTNENVLGKRIRDLHFKERYDVVISRLNRAGVELVASSDISLQFGDILNLVGRPSAIDAVANVLGNAQQKLQQVQMLPVFIGIGLGVLLGSIPVFVPGFPAALKLGLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLSVVGLKSGGDFIHTLVDGEGLSWIGYGALITAVPLITVGILARMLAKMNYLTMCGMLAGSMTDPPALAFANNLHPTSGAAALSYATVYPLVMFLRIITPQLLAVLFWSIG
What are the official names of this protein?
Putative transport protein YidE.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CLPC1_MYCS2
Sequence: MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLESLGISLEGVRSQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGGESGNPSTSLVLDQFGRNLTAAAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMTAPPDLREFDEKIADARREKESAIDAQDFEKAAALRDKEKQLVAQRAEREKQWRSGDLDVVAEVDDEQIAEVLGNWTGIPVFKLTEEETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKAVGLGFSQGGSENNYERMKQKVHDELKKHFRPEFLNRIDDIIVFHQLTQDEIIQMVDLMIGRVSNQLKTKDMALELSDKAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEIGPGQLVTVDVEGWDGEGQGEDAKFTFSGGPKRAETAEPDLAGAGAAGAPTAGTE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP (By similarity).  Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable).
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpC1.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. ClpC subfamily.
Protein: GPDA_LIMF3
Sequence: MKKVAVLGAGSWGSVLANLLVENGHQVMLWSRNQAQVDQLNQEHKNPHYMKDFTYNEGLVATSDMQAAVSGAAVILMVIPTKGVRQVAGQLAELLNGVTPAPLLVHATKGLEQNTYKRVSEMLAEEIPAASRRGIVVLSGPSHAEDVAIKDVTAVTAACGDLACAKEIQELFSNHYFRVYTNDDVIGAEFGAALKNIIALGSGALSGLGYHDNARAALITRGLAEIRRLGVAFGADPMTFIGLSGVGDLVVTATSKNSRNWRAGYQLGQGQKLADVVENMGMVIEGVATTKAAYELAQKRHVQMPITAALYRVLYEDEDIKSAIDGLMEREVTSEKE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNP2_METMJ
Sequence: MRPRPPAMRTKRRYILARILPYRARVDQKQMYFAVIEAATSLLGDAAAGLAQPAVVFCEGGYVVVRCRRGTEKDVAVALSTVTAVADERIALRTVATSGTIHALRRRMRSIRQLPGDEEVKIGETYFAVYRYPRQKVDLVEKGIKHQKSLFFTEADLEER
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 2, RNase P component 2, Pop5.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TILS_PROMM
Sequence: MASSSSTQLPWSAWHARLHHKLLANPDLLPAKASLLIAVSGGQDSMALLGLLIDLQRKHGWSLEVWHGDHNWHKQSATIATELKNWCESHNLSFCSDQAKPGQTNNEATARHWRYEQLTLHAERLSSNNPNHPCRYVLTGHTSSDRAETLLLNLARGTDLAGLSSMRQCRPISKDHPHKNVQLIRPLLGFSREDTALICSELGLPIWLDPANSNPDFSRNRVRQEVLPVLESLHPGCSLRMAALAERLNHHHADQQAIAMLALNNLSKQNGLCRKDLAQLPITARTTLLAYWLKRSGAPSLPAVQLEQISQSIAPGKPPGSLHLAQGWKVQWQRNSVQLEHHD
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_SHESH
Sequence: MPKLRSATSTEGRNMAGARALWRATGVKENDFGKPIIAIANSFTQFVPGHVHLKDMGSLVAGAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELISDSVEYMVNAHCADALVCISNCDKITPGMMMAALRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLVDAMVAGADDRVSDEDSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRIMDLTTRYYKHDDESALPRNIANFNAFENAMTLDIAMGGSSNTVLHLLAAAQEGEVDFTMEDIDRLSRLVPHLCKVAPSTPEYHMEDVHRAGGVMGILGELDRAGLIHNDAYHVAGASLKEVLAKWDIAQSSDEAVHRFFSAGPAGIPTTKAFSQACRWDSVDNDRVGGCIRKREFAFSQEGGLAVLSGNIAVDGCIVKTAGVDEDNHTFIGSARVYESQDDAVAGILGGEVVAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIGLVETGDRIEIDIPARSIKLAISDIELAARRSAMEARGKQAWKPVGRVREVSLALKAYALLATSADKGAVRDTSKLED
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: MOAA_SULIY
Sequence: MIDRFGRPLEDLRITLTHVCNFECFFCHMEGEEGDNYILSKEDILLVAKVAKNFDINSVKLTGGEPTLRRDLVEIVRGLKQLGYRDVSMTTNGFLLKDLAYKLKLAGLDRINVSLHAISRETFKKITGVDAFDRVIEGIKSAIDVGLVPVKLNFVVNRRNREEVFKFIELSQNLGVNEIHLIELHPVGLGKLAFKEHDDLREIEEYIEKISIKKQIRKKHFRPRYVLPSGLIVEVIKPYANPIFCAGCNRIRLSVDGKLKTCLYREDNVIDILDILKGEYSEDVKEELLGRAFMIAIAIREPNFKYKI
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
Probable GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: KCMA1_RAT
Sequence: MANGGGGGGGGSSGSSGGGGGGGGGETALRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEVVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDVTDPKRIKKCGCRRLEDEQPPTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELAKPGKLPLVSVNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQKKEMVYR
What is the function of this protein?
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+).  It is also activated by the concentration of cytosolic Mg(2+).  Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane.  It therefore contributes to repolarization of the membrane potential.  Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity.  In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential.  In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map.  Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits.  Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
What are the official names of this protein?
Calcium-activated potassium channel subunit alpha-1, BK channel, BKCA alpha, Calcium-activated potassium channel, subfamily M subunit alpha-1, K(VCA)alpha, KCa1.1, Maxi K channel, MaxiK, Slo-alpha, Slo1, Slowpoke homolog, Slo homolog.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 7]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Has a dominant-negative effect on other isoforms, preventing their localization to the cell membrane.
Protein: RL6_ACIBY
Sequence: MSRVAKAPVTVPNGVTVTQNGRQVEVKGSKGTLSFNLHALVELKQEEGKLQLAPAKESKDAWMQAGTARAVLNNLVKGVSEGFERKLQLVGVGYKAAVKGTVVNLNLGYSHPIDYALPEGVTAETPTATEIILKSANKQLLGQVAAEIRAYRSPEPYKGKGVRYSDEVILRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: LEU1_RENSM
Sequence: MRNAQKPSGMPVHRYLPFHEQIEVELPDRTWPTKRITTAPRWCAVDLRDGNQALIDPMSPARKLKMFELLVKMGYKEIEVGFPSASQTDFDFVRQLIQGGHIPEDVTIQVLTQAREHLIERTYESLVGAKQAIVHLYNSTSVLQRRVVFNEDQDGIMALATQGALLCKKYQETLTDTKITYEYSPESFTGTELDYAVRVCNAVADIFEASADNQVIVNLPATVEMITPNVYADSIEWMSHNLHPREGIILSLHPHNDRGTGVAAAELGYLAGADRIEGCLFGNGERAGNVDLVTLGLNMFSQGVDPMIDFSDIDEIRRTVEYCNQLPAPERMPYGGDLVFTAFSGSHQDAIKKGFEALERDADAAGIAVADTVWAVPYLPVDPKDLGRSYEAVIRVNSQSGKGGVAYLLKSEHSLDLPRRAQIEFSGVIQRRTDSVGGEVSADQRWEAFTDEYLPSPAGHPGGQWGRYALGSMNADTEEDGTTKLNTAMRIDGVEQRRSGSGNGPIAALLNILHDDGVDVRVLDYSEHALSEGGNASAASYVECAVGDRVLWGLGIDPNTTVSSLKAVISAVNRAIRDNQVD
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.