PharMolix/UniProtQA huggingface dataset:
Protein: DAPB_SALCH
Sequence: MHEAQIRVAIAGAGGRMGRQLIQAAMAMEGVQLGAALEREGSSLLGSDAGELAGVGKSGVTVQSSLEAVKDDFDVFIDFTRPEGTLTHLAFCRQHGKGMVIGTTGFDDAGKQAIREASQEIAIVFAANFSVGVNVMLKLLEKAAKVMGDYSDIEIIEAHHRHKVDAPSGTALAMGEAIAGALDKDLKDCAVYSREGYTGERVAGTIGFATVRAGDIVGEHTAMFADIGERVEITHKASSRMTFANGALRSALWLKTKKNGLFDMRDVLGLDVL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_CLOK5
Sequence: MDSEDRPIGFFDSGVGGISVLKEAVKILSNENFVYFGDSKMAPYGVRTVEEVKKLTFNAVEFLLKKNIKALVVACNTATSAAIIDLRKAYSKYMPIVGIEPALKPAVECNRKGNIIIMATPMTLAESKFNNLMKRYSNSNILPLPCSGLVELIEEGKTEGEEIERYLEEKLIPLKGNGIAAVVLGCTHYPFIKKSISKVLNQDVLILDGSKGTVRQLKRQLIKYHIESNKSKIGKIKIFNSMNSQYIIKLSYKLLKE
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: DER_PROM0
Sequence: MILPTIAIIGRPNVGKSTLVNRLCQSNDAIVFDKPGVTRDRTYQNASWGGKEFQIVDTGGLVFDDDSEFLPEIRTQVFLALEEASLALLVVDGNQGVTDGDLSIAKWLRNSSCKTIVAVNKCESTTLGISLASEFWKLGLGEPNPVSAIHGSGTGDLLDLVIGELPENNIQDDEEKIMMSIIGRPNVGKSSLLNSICGEKRAIVSDISGTTTDSIDTLIKKGDNHWKIIDTAGIRRKKNVKYGTEFFGINRAFKSIDRSDVCVLVIDAIDGVTDQDQKLAGRIEEQGRACIIVVNKWDLVEKNSSTIYQVEKELRSKLYFLHWSKMIFISALTGQRVDNIFEHALNAVNQHRRRVTTSVVNEVLKESISWKSPPTKRSGKQGRLYYGTQVKNKPPTFTLFVNDPKLFGITYRRYIEKQIRVNLGFEGTPLILLWRGKQQRALNKEVERENIELIQKD
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: TPPC2_DANRE
Sequence: MSGSFYFVMVGHHDNPVFELEFLPPGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFNDVYDLYVKFAMNPFYEVNAPIRSTAFERKVQFLGKKHLLS
What is the function of this protein?
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
What are the official names of this protein?
Trafficking protein particle complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. Sedlin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm. Note=Localized in perinuclear granular structures.
Protein: RS7_CAUVC
Sequence: MSRRRRAEKRQVLPDPKFGDLVVTKFMNYVMYEGKKAVAENIIYGAFDILEAKRKDQGPLETFHSALDNVAPAIEVRSRRVGGATYQVPVEVRPDRRRALAIRWLVTAARKRGENTMTEKLAGELLDASNNRGTAVKKREDTHKMAEANRAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: AROC_METC4
Sequence: MSHNTFGHLFRVTTFGESHGVALGCVVDGCPPGLALEAEDIQAELDRRKPGQSRFTTQRREPDQVKILSGVFSDDRTGGRQLTTGTPIALMIENTDQRSKDYSEIRDSYRPGHADFTYDAKYGIRDYRGGGRSSARETAARVAAGAVARKVIPGITIRAALVQMGPHAIDRANWDWEQVGQNPFFCPDAKAAALYETYLDAIRKDGSSVGAVIEVVAEGVPPGLGAPIYGKLDADLAAAMMSINAVKGVEIGDGFAAAALRGEDNADEMRAGNDGRPRFLANHAGGILGGISSGEPVVVRFAVKPTSSILTPRQSVNRDGAEIDLITKGRHDPCVGIRAVPVAEAMMACVLADHTLRHRGQNGERP
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PLSY_BRUA1
Sequence: MAEPGFFNAMLIGALIFGYVLGSIPFGLILTRLAGLGDVRAIGSGNIGATNVLRTGNKKLAAATLILDALKGTAAALIAAHFGQNAAIAAGFGAFIGHLFPVWIGFKGGKGVATYLGVLIGLAWAGALVFAAAWIVTALLTRYSSPSALVASLIVPIALYSRGNQALAALFAIMTVIVFIKHRANISRLLNGTESKIGAKG
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GCH42_CUPMC
Sequence: MNDINPAFVMPDVQSSVDTRQIVIQRVGVKGVRYPLTLKTPAGAVGTVGTFNMDVRLPADQKGTHMSRFVALLEENRAPLDLAAFRALVDDMLVRLEADAGRIEVSFPYFITKTAPVSGVQSLLDYEVTLVAEARDGQTRMFMTALVPVTSLCPCSKKISQYGAHNQRSHITMRVELAGDLDVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADDRIVAYTLEAENFESIHNHSAYAVIEHDKRHQ
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2 2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: TRPA_POLNS
Sequence: MSKITALFKELKATGKKGLIPFIAAGDPDPKQTVELMHALVRGGSSVIELGVPFSDPMADGPVIQRLSERALTHGVTLHSCLEMVKEFRKKDANTPVVLMGYANPVEQMGAERFATEAKAAGVDGVLVVDCPPEECVDFAARMRVAGIDPIFLLAPTSSQERIKGAAKIASGYIYYVSMRGVTGASHLNTQDVASIIPKIREETDIPIAVGFGISDAASAKAVSTSADAVVIGSQIIRLLEDAPSGQAVQSLETFIREIRDALDS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: THIC_NOSS1
Sequence: MRTEWVAKRRGQGNVTQMHYARQGVITEEMQYVARRENLPADLIREEVARGRMIIPANINHTNLEPMAIGIASKCKVNANIGASPNSSNLQEEVDKLNLAVKYGADTVMDLSTGGGNLDEIRTAIINASPVPIGTVPVYQALESVHGTIENLTPDDFLHIIEKHAQQGVDYQTIHAGILIEHLPLVRSRITGIVSRGGGILARWMLHHHKQNPLYTHFGDIIEIFKRYDVSFSLGDSLRPGCTHDASDDAQLAELKTLGQLTRKAWEHDVQVMVEGPGHVPMDQIEFNVKKQMEECSEAPFYVLGPLVTDIAPGYDHITSAIGAAMAGWYGTAMLCYVTPKEHLGLPNAEDVRNGLIAYKIAAHAADIARHRPGARDRDDELSKARYNFDWNRQFELSLDPERAKEYHDETLPADIYKTAEFCSMCGPKFCPMQTKVDADALTELEKFLAKEPVTQG
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: AATC_ORYSJ
Sequence: MASSSVFAGLAQAPEDPILGVTVAYNKDPSPVKVNLGVGAYRTEEGKPLVLNVVRRAEQMLINNPSRVKEYLPITGLADFNKLSAKLIFGADSPAIQENRVATVQCLSGTGSLRVGGEFLARHYHERTIYIPQPTWGNHPKVFTLAGLTVRSYRYYDPATRGLDFQGLLEDLGSAPSGAIVLLHACAHNPTGVDPTLDQWEQIRQLMRSKALLPFFDSAYQGFASGSLDQDAQSVRMFVADGGELLMAQSYAKNMGLYGERVGALSIVCGSADVAVRVESQLKLVIRPMYSNPPIHGASIVATILKDSAMFNEWTVELKGMADRIISMRQQLFDALKTRETPGDWSHIIKQIGMFTFTGLNSDQVAFMRQEYHIYMTSDGRISMAGLSGRTIPHLADAIHAAVTKLK
What is the function of this protein?
Important for the metabolism of amino acids and Krebs-cycle related organic acids.  In plants, it is involved in nitrogen metabolism and in aspects of carbon and energy metabolism.
What are the official names of this protein?
Aspartate aminotransferase, cytoplasmic, Transaminase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_CHLL2
Sequence: MGIGSYHEPVLAAEVLQLLVRMPGVYVDGTLGGGGHSLAILEELERKGFLADSFLIGIDQDDHALKAASEKLSGFSGSTAIIKGNFSAIAAIVRKISAERHFTDSVAGILLDLGVSSAQIDTPERGFSYMRSGPLDMRMDPEAESSAADLVNTLSERELVTLFFRYGEEPRSRSIARGIIDYREKHGSILRTEELAEIIRLREARPDRVIKTLSRVFQALRVEVNRELEVLEQVLADGASLLSAQGRLAVISYHSLEDRMVKSFFTAQSSSDWGPRGVGLTEPLKKAEFAVVTRKPVASGQQELSLNPRSRSAKLRVLEKLA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_GEOTN
Sequence: MHKDIATPGRTKEILARYGFSFKKSLGQNFLIDTNILRKIVDAAGISGDTGAIEIGPGIGALTEQLARRAKKVVAFEIDSRLLPILADTLSAYDNVRIIHQDVLKADLHAVIAEEFAEVSDRMVVANLPYYVTTPIIMKLLTERLPIRGMVVMMQKEVADRLAAKPGTKDYGSLTIAVQYYTEAEVVMTVPRTVFMPQPNVDSAVIRLTKRSHPPVAVEDEEVFFQVVRASFAQRRKTLLNNLLNNLPDGKEKKEQIERALDAVGIDPRRRGETLDMAEFASLSNALMPLFRV
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGD_VIBPA
Sequence: MTTEIKVERGLFDEVMVPCYNPMEMIPVRGKGSRIWDQDDNEYIDFAGGIAVSCLGHCHPVMVDALTEQGNKLWHLSNVMTNEPALRLAKKLTEVSFAERVFFANSGAEANEAALKLARRYAADVHGPEKSEIIAFKQGFHGRTFFTVTVGGQAAYSDGFGPKPGDVTHLPYNDIEALQAHMSDRTCAVMMEPLQGEGGIVPPTPEFAQAVRELCDKHNALLIFDEVQTGNGRTGHFYAYQGLGITPDILSTAKSLGGGFPIGAMLTTAKLAEHLKVGTHGSTYGGNPLACAVAEAVVNEVTKPEVLAGVLEREALFRAGLEKINAKYNLFSEVRGKGLLLGAALNEEWQGRARDVLVAAGKQGLLVLVAGANVVRFTPSLVITQQEIEEGLAKLDKAIATLV
What are the official names of this protein?
Acetylornithine aminotransferase, ACOAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBB1_AVESA
Sequence: AVLMDLEPGTMDSVRTGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDSKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPTGLSMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEEGEYEDEEEDLQAEDM
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-1 chain, Beta-1-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y074_MYCGE
Sequence: MRQFIKLSLLVFVLLFLSELICRFSLRLVNSIKARYKSSVFSYTACLLFLKSFQNFSNAFQKLANWVFWFENDVNELLSIFYFNFDQKSEKVDYNFFNGYKVTAQKVVEKEQLLTCKLSDYYRLFRDKTFWFELINN
What are the official names of this protein?
Uncharacterized protein MG074.
Protein: PERR_STAAR
Sequence: MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK
What is the function of this protein?
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins.  May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
What are the official names of this protein?
Peroxide-responsive repressor PerR.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR23A_DROME
Sequence: MKLSETLKIDYFRVQLNAWRICGALDLSEGRYWSWSMLLCILVYLPTPMLLRGVYSFEDPVENNFSLSLTVTSLSNLMKFCMYVAQLTKMVEVQSLIGQLDARVSGESQSERHRNMTEHLLRMSKLFQITYAVVFIIAAVPFVFETELSLPMPMWFPFDWKNSMVAYIGALVFQEIGYVFQIMQCFAADSFPPLVLYLISEQCQLLILRISEIGYGYKTLEENEQDLVNCIRDQNALYRLLDVTKSLVSYPMMVQFMVIGINIAITLFVLIFYVETLYDRIYYLCFLLGITVQTYPLCYYGTMVQESFAELHYAVFCSNWVDQSASYRGHMLILAERTKRMQLLLAGNLVPIHLSTYVACWKGAYSFFTLMADRDGLGS
What is the function of this protein?
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates.  The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration.  May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
What are the official names of this protein?
Odorant receptor 23a.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COAD_BACAC
Sequence: MTSIAISSGSFDPITLGHLDIIKRGAKVFDEVYVVVLNNSSKKPFFSVEERLDLIREATKDIPNVKVDSHSGLLVEYAKMRNANAILRGLRAVSDFEYEMQITSMNRKLDENIETFFIMTNNQYSFLSSSIVKEVARYGGSVVDLVPPVVERALKEKFQTPLK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_AROAE
Sequence: MQFELLAQHGAARRGRLTLAHGTVDTPAFMPVGTYGTVKAMTPAALADTGAQICLGNTFHLWLRPGLDVVAAHGGLHRFMNWDRPILTDSGGFQVFSLGALRKISEEGVKFASPIDGAKLFLTPEESMRIQTVLNSDIAMIFDECTPHPATHDEAAKSMQLSLRWARRSRDEFDRLANPNALFGIVQGGMFEDLRDESLAALDAIGFSGYAIGGLSVGEPKEDMARILAHTAPRLPAGRPRYLMGVGTPEDIVAGVAAGIDMFDCVMPTRNARNGWLFTRYGDIKIKNATHKQDTRPLDPSCDCYTCRNFSRAYLHHLHRAGEILGSMLNTIHNLRYYQTLTAELRAAIAAGDLDSHAARFRADRSTGAC
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: ANR54_RAT
Sequence: MAATGGGAEDESRSGRSSSEGECAVAPEPLAEAGGLFSFADLGAALGSGAGLPGRAVGRAQSPLRYLQVLWQQDVEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDIETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQQDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHSQCLEAVRLEVKQIIHMLREYLERLGRHEQRERLDDLCTRLQMTSTKEQVDEVTDLLASFTSLSLQMQSMEKR
What is the function of this protein?
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
What are the official names of this protein?
Ankyrin repeat domain-containing protein 54.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Midbody. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation (By similarity).
Protein: GBRA1_HUMAN
Sequence: MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750).  The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).  The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750).  GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity).  Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
Protein: RBL_NELCA
Sequence: VGFKAGVKEYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYNIEPVPGEADQYICYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMMKRAIFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAAANRVALEACVQARNEGRDLAAEGNTIIREASKWSPELAAACEVWKEIKFEFKAVDTLD
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EFP_SACEN
Sequence: MASTNDLKNGLVLNLDGQLWSVVNFQHVKPGKGGAFVRTTLKNVLSGKVVDKTFNAGVKVDTANVDRREMTYLYNDGTDYVFMDPDTYDQVGVAASVVGDAADYMLENSQVVVARHDDNPLYVELPASVELDIQHTDPGVQGDRSTGGTKPATLETGAEIQVPLFLNTGDKVKVDPRDGRYLGRVSTK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_PROMS
Sequence: MSYKQVIIIGAGLAGSEAAWQVASSGVPVKLVEMRPIKSTPAHHTSEFGELVCSNSFGALSPDRAAGLLQKELRIFNSLIVQTADKFAVPAGGALAVDRSKFSIALTEALSNHPLIEIKRFEQLDLPSKENITILATGPLTADELSYKIQAFTGIDACHFFDAASPIIYGDTIDQEIVFKASRYDKGDPAYFNCPMGKNDYINFRNELIKGEQVNLKDFEKESANFFEACLPIEEIARRGVDTMRYGPLKSIGLWNPKWGDLFDRENRLKKRPHAVVQLRKEDLEGKLLNMVGFQTNLKWSEQKRIFRLIPGLEKAEFVRFGVMHRNTFLESPKLLLPTLQFLKRENLFAAGQITGTEGYAAAAAGGLLAGINASLLAKGKKTVSFPDQSMIGSLMNFISNKNQILSNQQKNKFQPMPASFGLVPELIKRIKDKRLRYKAYQERSTEALNDFKNQLDSCFDKDHLLSKIY
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_CERS1
Sequence: MQEFTKVTGVAAPMPLVNIDTDMIIPKQFLKTIQRSGLGKNLFDEMRYNPDGSEIPEFVLNQPAYRDAQIIVAGDNFGCGSSREHAPWALLDFGIRCVISTSFADIFYNNCFKNGILPIVMPPEVVEVLMEDARRGANARMTVDLEAQTVTTSDGQSFPFQVDSFRRHCLMNGLDDIGLTLEKAASIDGFERDLATLRPWV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: ATPG_BURPS
Sequence: MAGMKEIRGKIKSVQNTRKITKAMEMVAASKMRRAQERMRAARPYAEKVRAIAAHMSRANPEYRHPFMVANDGVKTAGMILVTTDKGLCGGLNTNVLRASLQKFKELEEQGQKVEATAIGGKGLGFLNRFGAKVISQVVHLGDTPHLDKLIGAVKTQLDLYSEGKLSAVYLAYTRFVNTMKQETVIEQLLPLSSEHFDANDGTPATSWDYIYEPDAQAVVDELLVRYVEALVYQAVAENMASEQSARMVAMKAASDNAKTVISELQLSYNKSRQAAITKELSEIVGGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.