PharMolix/UniProtQA huggingface dataset:
Protein: SNX33_MOUSE
Sequence: MALKGRALYDFHSENKEEISIQQDEELVIFSETSLDGWLQGQNSRGETGLFPASYVEIVRPGISTNHVDYSNSPAGSLGTQGSLYSSPSMASPARSGGGSGFLSNPGSFEDDDDDDWDDWDDGCTVVEEPLAGGLGTNGHPPLNLSYPGAYPNQHMAFRPKAPLERQDSLASAKRGSVVGRNLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSIEDPTKQTKFKGIKSYISYKLTPTHAGSPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDTFKAFSKKMDDSVLQLSNVAAELVRKHVGGFRKEFQKLGSAFQAISHAFQMDPPFRSDALNNAISHTGRTYETVGEMFAEQPKHDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRMAQEEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQSYLRQQILFYQRVGQQLEKTLHMYDHL
What is the function of this protein?
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2.  Acts both during interphase and at the end of mitotic cell divisions.  Required for efficient progress through mitosis and cytokinesis.  Required for normal formation of the cleavage furrow at the end of mitosis.  Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides.  Promotes membrane tubulation (in vitro).  May promote the formation of macropinosomes (By similarity).
What are the official names of this protein?
Sorting nexin-33, SH3 and PX domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily detected in the cytosol. A minor proportion is membrane-bound (By similarity).
Protein: CPSD_STRA1
Sequence: MTRLEIVDSKLRQAKKTEEYFNAIRTNIQFSGKENKILAITSVREGEGKSTTSTSLALSLAQAGFKTLLIDADTRNSVMSGTFKATGTIKGLTNYLSGNADLGDIICETNVPRLMVVPSGKVPPNPTALLQNAYFNKMIEAIKNIFDYIIIDTPPIGLVVDAAIIANACDGFILVTQAGRIKRNYVEKAKEQMEQSGSKFLGIILNKVSESVATYGDYGDYGNYGKRDRKRK
What is the function of this protein?
Involved in the regulation of capsular polysaccharide biosynthesis.  Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation.  May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide.
What are the official names of this protein?
Tyrosine-protein kinase CpsD.
What is the protein family that this protein belongs to?
Belongs to the CpsD/CapB family.
Protein: TPIS_MESH7
Sequence: MKKIIIGNWKMNKTVSETRDFIQKFDIFYQENVGKIKEDLDFAIAPSFISLSLISKSLTKKLEIAAQNLSQFDSGAFTGEISGKMLQDLGTKYVIIGHSERREIFKEKDEELKNKILQAQKYDLIPVFCVGESLLEFEAGLTKKVIISQINAIKSVLNFQKAIIAYEPIWAIGTGKTATAAIAEKVCGMIKENFGKDTTVIYGGSVNSKNINELVSQKSIDGALVGGASLDPEEFGKILVNS
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABV_BURO0
Sequence: MIIKPRVRGFICVTTHPVGCEANVKEQIDYVTSHGPIANGPKKVLVIGASTGYGLAARISAAFGSGADTLGVFFERAGSETKPGTAGWYNSAAFEKFAAEKGLYARSINGDAFSDKVKQVTIDTIKQDLGKVDLVVYSLAAPRRTHPKTGETISSTLKPVGKAVTFRGLDTDKEVIREVSLEPATQEEIDGTVAVMGGEDWQMWIDALDEAGVLADGAKTTAFTYLGEQITHDIYWNGSIGEAKKDLDKKVLSIRDKLAAHGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKETGTHEGCIEQVYGLLKDSLYGATPHVDEEGRLRADYKELDPQVQDKVVAMWDKVTNENLYEMTDFAGYKTEFLRLFGFEIAGVDYDADVNPDVKIPGIIDTTV
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: HFLD_PSEE4
Sequence: MNNLQEQLIALGGVFQAAVLVDRIARTGQASEANIGCMLGSLLVRDPKDTLEVFGGDDLNLRDGYRALVGALERDPSSLQREPLRYALSMLGLERQLNKRGDMLDIIGNRLPQIQSQADHFGLVHENVIASSGALYQDTLSTLRQRIQVHGDMRFLQQASNASKIRALLLAGIRAARLWRQLGGHRWQLVFSRRKLLKELYGMMRTTD
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: APRL6_ORYSJ
Sequence: MAARLLAPLLLLLLLAPLPPPAAAAEPEEARCPRERLPPFVAAAAAAALRPSCRASAERCPAEEINGEELVKELSGKEECTAVLFYASWCPFSQRMRPVFDDLSSMFPRIKHLAVEQTNAMPAVLSRYGVRSFPSILIACGPYAYWPVGSKELDSLVNVYTAVTGQEPIAYLGPRKWSAARTGSTQHVKLWKSSIIEALKSEPYLAFSILFICLKILVAFFPKFFSCIKGIWVQYFRHANLGILAKLTQLLECVPHAVDLRKIWSKCRLMGGAMNSRVWASSLASMSFGERSSPRAAVLD
What are the official names of this protein?
5'-adenylylsulfate reductase-like 6, Adenosine 5'-phosphosulfate reductase-like 6, APR-like 6, OsAPRL6.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: BLUB_RHOCB
Sequence: MNFEQTHRDALTEVLRWRRDVRHFRPDPIDEAVIDRLRAVMDMAPSVGNARPWRVIRVDSPALRAEVLANFNAARAAAGSAYAGEQAEAYATLKLQGIDQAPLQLAVFTHRDPAAGHGLGRASMPVTLQQSTAMAIHTLWLAARAENLGLGMVSVLDPKAVERLLNAPPDWDFVAWLCIGVPEFTDDTPLLHRAGWQENLPTEWERR
What is the function of this protein?
Involved in the biosynthesis of cobalamin (vitamin B12).  Catalyzes the oxidative fragmentation and contraction of the isoalloxazine heterocycle and the cleavage of the ribityl tail of FMNH(2) to form 5,6-dimethylbenzimidazole (DMB) and D-erythrose 4-phosphate (E4P).  NAD(P)H is only required initially to reduce FMN and oxygen drives the oxidative fragmentation (By similarity).
What are the official names of this protein?
5,6-dimethylbenzimidazole synthase, DMB synthase.
What is the protein family that this protein belongs to?
Belongs to the BluB family.
Protein: TIM14_GIBZE
Sequence: MASVMAWGAGAAVAAFLGRAGLVAWRRSRGGVGAMGKAFYKGGFEAKMTKKEATLILSLNERAITKDKVRKAHRTLMLLNHPDRGGSPYLATKVNEAKEFLDKNG
What is the function of this protein?
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM14, Presequence translocated-associated motor subunit PAM18.
What is the protein family that this protein belongs to?
Belongs to the TIM14 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: RL13_LIGS1
Sequence: MRTTYIAKPGEVERKWYVVDATDVPLGRLSSAVASILRGKNKPTFTPNVDTGDYVIVINAEKVALTGRKASNKVYYHHSNHPGGLKARTAGDYREKDPEKLLALSVKGMLPKGTLGRQQAKKLHVYRGADHKHEAQQPEVLDINKLI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PRIS_METM6
Sequence: MNDNPAVNKVFNEISSLYKQYFEYAIKVRKWLEIPDDLSHREIGYGMLKKVDNRNMSFNTDGEYLTWVLKESPFHLYKSLSYMEYPDVVGGAAKKGLFKREVAFDIDTHKTEKCTHDDSWICEECLGEARNQVLILIEDFLFPDFGLSEKDLKIVFTGNRGYHIYLKPENPELLKKIEKWGKNERRYFIEYILGKNLNLRNMGSRWKNILIREFKKNKIATKKFEKTSDWKTEIDTRKDTTRRTIYETIGKVKSRLELDEKVMDDDIRLLRTIGSLHGYTGLMVKEITYSSLKNNQFDPLNHGVFSKFHKIMYKVNIKQEIDPLTLKGDTFDHKSTEIPASYLLFLFGHGIDFEILE
What is the function of this protein?
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  The small subunit contains the primase catalytic core and has DNA synthesis activity on its own.  Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase small subunit PriS.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: QUEC_PARXL
Sequence: MIRKDAKRSALVLFSGGQDSATCLAWALERYETVETLGFDYGQRHRVELECREGFRNAVVRAFPAWADRLGEDHMIDLSVLGAISDTAMTREIEIEATANGLPNTFVPGRNLMFMTIAAAIAYRRGLQVLVGGMCETDFSGYPDCRDDTMKALQVALNLGMDTRFLLETPLMWLDKADTWRLAHELGGAELVELVRVETHTCYLGERAELHAWGFGCGECPACRLRKRGYEAYLAGENVTEPV
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: SELN_DANRE
Sequence: MAADVDKTPAGEQKDDHEDRGTPSSRRGRSRFTQISSLFIIAAIPVIGVCIKYYLDIQFVKRHEAGLKALGADGLFFFSSLDTDHDLYLSPEEFKPIAEKLTGVAPPPEYEEEIPHDPNGETLTLHAKMQPLLLESMTKSKDGFLGVSHSSLSGLRSWKRPAISSSTFYASQFKVFLPPSGKSAVGDTWWIIPSELNIFTGYLPNNRFHPPTPRGKEVLIHSLLSMFHPRPFVKSRFAPQGAVACIRATSDFYYDIVFRIHAEFQLNDVPDFPFWFTPGQFAGHIILSKDASHVRDFHIYVPNDKTLNVDMEWLYGASETSNMEVDIGYLPQMELGAEGPSTPSVIYDEQGNMIDSRGEGGEPIQFVFEEIVWSEELRREEASRRLEVTMYPFKKVPYLPFSEAFSRASAEKKLVHSILLWGALDDQSCUGSGRTLRETVLESSPVLALLNQSFISSWSLVKELEDLQGDVKNVELSEKARLHLEKYTFPVQMMVVLPNGTVVHHINANNFLDQTSMKPEDEGPGLSFSAGFEDPSTSTYIRFLQEGLEKAKPYLES
What is the function of this protein?
Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis.  Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage (By similarity).  Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:18713863).  Plays an important role in muscle development and differentiation during early development.  Required for development of the slow muscle fiber lineage (PubMed:18713863).  Required for the correct organization and attachment of the myofibrils, as well as for the continuity and integrity of the connective tissue that forms the myoseptum (PubMed:17123513).
What are the official names of this protein?
Selenoprotein N, SePN, SelN.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane.
Protein: REDF_ECOLI
Sequence: MSGSVIHSQSAVMVPAVYSAGQPASLPVAIDYPAALALRQMSMVHDELPKYLLAPEVSALLHYVPDLHRKMLLATLWNTGARINEALALTRGDFSLAPPYPFVQLATLKQRTEKAARTAGRMPAGQQTHRLVPLSDSWYVSQLQTMVAQLKIPMERRNRRTGRTEKARIWEVTDRTVRTWIGEAVAAAAADGVTFSVPVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKVFALDVAARHRVQFAMPESDAVAMLKQLS
What is the function of this protein?
Acts as a repressor of transcription and as a site-specific resolvase that cleaves at the RfsF site.
What are the official names of this protein?
Resolvase, Protein D.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: PNP_RHOBA
Sequence: MSVQKVRVERKIGDSVLSFETGHIAKQAAGSVLVQYGETVVLVAAASGTPRPGIDFFPLMCDYRERLAAAGKFPGGFLKREGRPSTKEILSSRLMDRPIRPLWPAGYKDEVQVQACVIASDLQNDGDVLAMIGGATALHISPLPFKGPLGSVRVGKVDGKLVAFPTADQLEQSELDMIVSGSRDMVAMIEGFANEMPEDEMMEAIGFAHDAIREVIDLQEEFYKKVNPEKTPYQSPEDDGLLQRLTDAYYSDFKTAQQTSGKQARAEAVRAVRDRAMADVIPDPNAADAVCVNRFKSVWHDLEEKVVRDLILAGTRPDGRDHNSLRAIHCETDLLPRVHGSALFQRGETQALITIALGTSRDEQRVDGLQDEYSKKFMLDYNFPSYSVGECRPIRGPGRREIGHGCLAERSVAPVLPSADDFPYTIRVISDITESNGSSSMASVCGATLGLMASGVPISNPVAGISVGLVQDGPDNWCLITDILGTEDHFGDMDFKIAGTQNGITGIQLDLKVTGVTNDIIRATLKQSREARIEILKKMLTTIPRPRREISPTAPRLLRTKISPDKIGALIGPGGKNIRGIQETTGAVIEVDDEGTVLVASSNKESAQEAMRQVEACTATVQIGKIYDGTVSSIKEFGAFVEILPGRDGLVHISEMSGGYISSLDQVIAVGDAMKVLVIDVDEHDRVKLSRRKALEELGEEDPLAVEGEGGGDSEGGGDGEDRPRRRRGGSGGGGGGGRGRGPRRSGGGRDRD
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1195_STRPQ
Sequence: MADKFDANDETRTVYAVVYDNDQPVSTGQFLAETKIEARLTRIVTLADYCGCGYGAKVTEALETYTRREGFYQLTIHSELTAQTFYENLGYQTYGPKCLEDGEYCQSLAKTILKWEKNMDIAMLIAIVGGLLGCYLYLTKNN
What are the official names of this protein?
Uncharacterized acetyltransferase SPs0667.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: ZMAT3_RAT
Sequence: MILLQQVWLPLPNRPSTSPPMSVAARSTGTLQLPPQKAFGQEASLPLAGEEDLAKRGEPDSALEELCKPLFCKLCNVTLNSAQQAQAHYQGKNHGKKLRNYYAANSCPPPARMSSVAEPVATPLVPVPPQVGSCKPGGRVILATENDYCKLCDASFSSPAVAQAHYQGKNHAKRLRLAEAQSHSFSDSAEAGQRRTRKEGSEFKMVTTRRNMYTVQSNSGPYFNARSRQRIPRDLAMCVTPSGQFYCSMCNVGAGEEVEFRQHLESKQHKSKVSEQRYRSEMENLGYVQ
What is the function of this protein?
Acts as a bona fide target gene of p53/TP53.  May play a role in the TP53-dependent growth regulatory pathway.  May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.
What are the official names of this protein?
Zinc finger matrin-type protein 3, Zinc finger protein WIG-1, p53-activated gene 608 protein.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.
Protein: TE2IP_BOVIN
Sequence: MAEAMELGKDPNGPTHSSTLFVREDGSSMSFYVRPSPAKRRLSTLILHGGGTLCRVQEPGAVLLAQPGEAAAEASGDFISTQYILDCVERNEKLELEAYRLGPAPAAYQAPETKPGVLAGGVAAAEPEPQSQAGRMVFTDADDVAIITYVKEHARSASSVTGNALWKAMEKSSLTQHSWQSMKDRYLKRLRGQEHKYLLGEAPVSPSSQKLKRKAEQDPEAADSGEPQNKRTPDLPEEEFEKEEIKENEAAVKKMLVEATREFEEIVVDESPDFEIHITMCDDDPCTPEEDSETQPDEEEEEEEKVSAPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSSFLESGQRADGYPIWSRQDDLDLQKDDEATRDALVKKFGAQNVARRIEFRKK
What is the function of this protein?
Acts both as a regulator of telomere function and as a transcription regulator.  Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome).  In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair.  Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length.  Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2.  Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression.  When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).
What are the official names of this protein?
Telomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Repressor/activator protein 1 homolog, RAP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the RAP1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.
Protein: Y053_NPVOP
Sequence: MLLTVYLKDKQYYLFKLFREIWPSCTTECRICLETLGTEGGVVGVPDNGLLNLDKMFHAECIERWKRGRNRDPFNRAIKYYFAFPPPTLHECKALLEHTRGFIGDDEMDRVYSLVHQRVTTEDALDVELNFARFFKDDARAVGGGQ
What are the official names of this protein?
Uncharacterized 17.0 kDa protein.
Protein: RL3_SYNWW
Sequence: MTTKKKAIMGIKIGMTQIFDENDKAVPVSIIEAGPCTVLQKKKVESDGYESIQVGFYNLKEKLANKPARGHFKKANVKPLRYIKEFRIDNVDDYDVGQEITADIFTTGDLVDVIGTSKGKGFAGGVKRHNFARGSMGHGSKYHRRPGSLGAKGPARVFKGRKLPGRLGGERVTVQGLKVVKVYPDRNLILIKGSIPGPKRGFVIIKNSVKEK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: AAEB_PECPW
Sequence: MKTSLLADPLFFTTPQLARFRFAFKLTFAVVLSLFLGFHLQLGTPNTAVMTAAIVAGGPAFVAGGEPFSGAIRHRGMLRIVGTFIGCIGALAIIISTIRAPIVMMLLCCIWAGLCNWISSLVKIENSYIFGLAGYTTLIIILATQGTPMLTPQFAVERCSEIVLGIACVIFADLLFAPRSIKQDVDRSLRELMVGQYRLLQLSMSGADEGTIDTTWHALVRKTTALDGMRSNLMMESSRWQNSNRRLTSLHTQSLTMITQACETYLTLQDVPTHVKSSLKQVLDPPVESFGDVHHHVKALRHLIAADSRDVPPTLVSWVGAATRYLLLVKGVQTNGRISKIEADVLNHDVEIKVPSAETHHAMINGLRTGVATALGCLFWLSTGWSSGGICMMMIAVVTSLAMRLPNPKMVGMDFLYGTIYSLPLGALMFMFILPSTQQSILLLCLSLGAMTFFLGVEVQKRRLGSLGALISTINVLLLNNPMTFNISLFLDNAIGQIIGCFVALMVILLIRDNTKSHTGRTLLNRFVYGAVSALTTDTTRRKENHLPALYQQLFLLLNRFPDDMAKYRLALWMIIMHQRLRTLDIPQNAALSAFHRQIRATAEQVILARRDTTRSRYFTQLLEELERYQQILTEQQLPPNVTVPVGRLTGILRDYQHALSD
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CH10_AERSA
Sequence: MKIRPLHDRVIIKRIEAEAKSAGGIILAGTAAQKSTRGEVLAVGTGRILDNGDVKALAVKVGDKVIFNEGYGVKTEKLDGQDVLILSETDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CIDEB_BOVIN
Sequence: MEYLSNLDPSSLLRSVSNMSADLGRKVWTSAPPRQRPFRVCDNKRTTRKGLTAATRQELLDKALEALVLSGALTLVLEEDGTTVESEEFFQLLEDDTCLMVLELGQSWSPRRSGVLSYGLGQEKPKHSKDIARITFDVYKQSPRDLFGSLNIKATFYGLYSLSCDIQGLGPKKILRELLRWASSLLQGLGHMLLGISSTLRRAVEGTERWQRQGRLKPY
What is the function of this protein?
Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion.  Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (By similarity).  Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets.  The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity).  Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes.  In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport.  Required for very-low-density lipoprotein (VLDL) lipidation and maturation.  Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles.  Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles.  May also activate apoptosis (By similarity).
What are the official names of this protein?
Lipid transferase CIDEB, Cell death-inducing DFFA-like effector B.
What is the protein family that this protein belongs to?
Belongs to the CIDE family.
Protein: NUSB_THET8
Sequence: MRRRARELAMRALFAHTVGGMGLEEAFQHALEEMGGEEEGYAEPLDQEGVAFARRLLSGYKAHQEEVDRVLEETVEGWDFRQMAKTDLAVLRLAVYEMLYEPTPFEPLIEVAVKIANRYGGEHSGSFVNGVLARVYRRVAAGELKTVAKEA
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: NSUN5_DROME
Sequence: MSKKPHSIKVPTQYRATAKILKAALEQQKCIKTLIFAEKHARTRSLHTVLKKFSENRVALEKAIEETGLLRDNPSFDPSLAKILVTELLFGRKELNGESKPVQTVRSYKDRLLNSIRDFGVQRKEPNPRYVRINTNLYSLAEALDYLHKSDWRRKELPADASYADFLTAIKSLAENEFMTDLHVEGVLIFPAKWSNYWVRHPLVHSKRFILQNKATCLAAELLAPPSGATVLDMCAAPGMKTVHICNVMQNKGCIYSVEQDHVRYNTLCEITKDAGCDIVKPILGDALNLTPERFPDVEYILVDPSCSGSGMQNRMTVCDEPKEDKRLQKLQGLQIKILSHAMGAFPNVKRIAYCTCSLWKEENEQVVQRCLQLNPSFKLLSCKKALRNKWHNVGDKDYPNIGKNVLYCQPDSDLTDGIFLALFEKRREGEKD
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 28S rRNA.
What are the official names of this protein?
28S rRNA (cytosine-C(5))-methyltransferase, NOL1/NOP2/Sun domain family member 5.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Protein: TILS_BRADU
Sequence: MSDDDNSPISAREAKQLFAELKSAPALVLAVSGGPDSIALMWLAARWQRSLARGPRLTVVTVDHGLRAEAAREAREVKRLATELGLPHRTLRWRGAKPKTGLPAAAREARYRLLMQAARSAGASHVLTAHTRDDQAETLLMRLVRGSGLAGLSAMARLTERDGIVLARPLLDVPKAQLIATLKRAKIGFADDPTNRDTAFTRPRLRALLPQLAAEGGDARSLARLAARLARANAAVEVLTDGAERFLRLRDRDDAPHGPDMRSFEAGAFATLPEEVRLRMLLRAINALGHEGPAELGKVETLLAALDQAIAAGMAAAPRAAVNGRPVLKQTLAGALISLAGGRIQIAPAPARRRKGDRGGS
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.