PharMolix/UniProtQA huggingface dataset:
Protein: SEPF_STRPN
Sequence: MSLKDRFDRFIDYFTEDEDSSLPYEKRDEPVFTSVNSSQEPALPMNQPSQSAGTKENNITRLHARQQELANQSQRATDKVIIDVRYPRKYEDATEIVDLLAGNESILIDFQYMTEVQARRCLDYLDGACHVLAGNLKKVASTMYLLTPVNVIVNVEDIRLPDEDQQGEFGFDMKRNRVR
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA (By similarity).
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: PURA_BORA1
Sequence: MSKNVVVIGTQWGDEGKGKIVDWLAESVQGVVRFQGGHNAGHTLWINGKKTILRLIPSGIMHPGVTCYIGNGVVLSPEALLKEIEELEAAGLDVRSRLQISEICPLILPYHVAVDKAREARKGESKIGTTGRGIGPAYEDKVARRALRVQDLFTPDIFDAKLDEVLDYHNFVLTQYLGAQAVSANEVRDQAMALAPAIKPMVRDVSSSIFLAQQQGARFLFEGAQGALLDVDHGTYPYVTSSNCVAGAASAGAGVGPQSLDYVLGITKAYTTRVGSGPFPTELLDEVGSRLATVGKEFGSVTGRPRRCGWFDGAALKRSVRLNGISGLCITKLDVLDGLEKLQLGVGYRVNGEFRDVLPYGAHAVAQAEPVLEELPGWSESTVGVTEYSKLPLNARRYLERVAEVCGVPIDLVSTGPDRNETIVLRHPLKG
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRYAA_ALLMI
Sequence: MDITIQHPWFKRALGPLIPSRLFDQFFGEGLFEYDLLPLLSSTISPYYRHSLFRSVLESGISEVRSDRDKFTIMLDVKHFSPEDLSVKIIDDFVEVHGKHNERQDDHGYISREFHRRYRLPSSVDQSAVTCVLSADGMLTFSGSKVQSNVDTIHSDRPIPVAREEKPTSAPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  May act as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock.
Protein: NDB46_MESEU
Sequence: MKSQTFFLLFLVVFLLAITQSEAIFGAIAGLLKNIFGKRSLRDMDTMKYLYDPSLSAADLKTLQKLMENY
What is the function of this protein?
Amphipathic peptide that exhibits extensive cytolytic activities against both prokaryotic and eukaryotic cells.  Is more potent against Gram-positive bacteria (lethal concentration (LC)=0. 25-2. 9 uM) than against Gram-negative bacteria (LC=6. 2->50 uM), and fungi ((LC)=14. 1->50 uM).  Shows hemolytic activity against rabbit erythrocytes (37. 7% of inhibition at 6. 25 uM) and cytolysis against rat dorsal root ganglions.  In vivo, intravenous injection into mice tail provokes uncomfortable symptoms with a death rate of 12. 5%.
What are the official names of this protein?
Venom antimicrobial peptide-6, MeAMP-like toxin, Meucin-13, Non-disulfide bridged protein family 5, NDBP-5, Non-disulfide-bridged peptide 4.6, NDBP-4.6, VAMP-2.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: RL1_ANAMM
Sequence: MSGDGSCSYSAEEGIRELLQSAKAKFRESVDVAIKLSVADSKSGESIRGAVVLPKGLGREVRVAVFAKGEHAKQASSAGADVVGDEELIEEIKKGRRLDVDWCIATPDFMPQISAIAKILGPRGLMPNPKFGTVTLELAEMVGIIKSGQVKFKSDRYGIVHVKIGDIGFTPEDLLENFNAVVAAVQGLRPTTIKGSYVRGVFVNSTMGRSFRIAGTG
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: PT1_STAAS
Sequence: MSKLIKGIAASDGVAIAKAYLLVEPDLTFDKNEKVTDVEGEVAKFNSAIEASKVELTKIRNNAEVQLGADKAAIFDAHLLVLDDPELIQPIQDKIKNENANAATALTDVTTQFVTIFESMDNEYMKERAADIRDVSKRVLSHILGVELPNPSMIDESVVIVGNDLTPSDTAQLNKEFVQGFATNIGGRTSHSAIMSRSLEIPAIVGTKSITQEVKQGDMIIVDGLNGDVIVNPTEDELIAYQDKRERYFADKKELQKLRDADTVTVDGVHAELAANIGTPNDLPGVIENGAQGIGLYRTEFLYMGRDQMPTEEEQFEAYKEVLEAMDGKRVVVRTLDIGGDKELSYLNLPEEMNPFLGYRAIRLCLAQQDIFRPQLRALLRASVYGKLNIMFPMVATINEFREAKAILLEEKENLKNEGHDISDDIELGIMVEIPATAALADVFAKEVDFFSIGTNDLIQYTLAADRMSERVSYLYQPYNPSILRLVKQVIEASHKEGKWTGMCGEMAGDETAIPLLLGLGLDEFSMSATSILKARRQINGLSKNEMTELANRAVDCATQEEVIELVNNYVK
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
What are the official names of this protein?
Phosphoenolpyruvate-protein phosphotransferase, Phosphotransferase system, enzyme I.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP221_ARATH
Sequence: MRRRPGIGGLQKAAAARDQYRLLGENVAKLRTDMMKEQLSTFRSQLEEFARKHKNDIRKNPAFRAQFHEMCANIGVDPLASNKGFWAELLGIGDFYYELGVQIIEVCMLTRSHNGGLISLQELCNHLRQRRKKDREAVTEDDCLRAISKLKVLGSGFEVITIGKKKLVRSVPTELNKDHNQILELAQGQGFVIVEEVQRRLSWTSGRVIDALETLLEEGLAMIDNGHKDGKCRYWFPCVSSVYSSIGSDT
What is the function of this protein?
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.  The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 22 homolog 1, AtVPS22-1, ESCRT-II complex subunit VPS22 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the SNF8 family.
What are the subcellular locations of this protein?
Endosome.
Protein: YL066_MIMIV
Sequence: MTADLPYEIWMNIIEYLGNDTINLLLVSKYLFFLATFCNISKKKLYKSIIKNGYIDILKYIRELTVNGEISAKIKMDKNLSMLLATKYGKLNIIKYLVRNGTDIRICNNYPVRKASKYGYLDIVKYLIREDCDVSDYDNYALRKATKNGYFEIVKLLVDQGADVHCCDNAPIKLACKYGYSKMVKFFHKKFLDVNYDFNEDLLLKLASSGGHYKIVKYLVTKSNNIHFEDSLISVIKKGHLDILKYFISKGVILGNNKNIRNATLMACKKGHYNVVEYLIDNIISIENMKKKYSCDIEIDIFKKNLITNTCISGNLDMLKYLISKGINVAFEDNLPIKISACHDHLHLVKYLVSISNVKINYENILISASENGCIKVVKYLVDKGVNVKDNTAIYSAGINGYLQIVKFLESNGADLIKYHNEIFLECSSNGYLNVIKYIVSKYNINKSIYDKALIIASKNNQLKTVKYLVHMGADIKSIKFHDMEKIIDNDLELLKYLVSKGLKINNIYKNLISKIIMNNDLDKLKYLISLGVNMKCIRIDTFNSCIQNRNKEMLSYLISRKIKLICYCEEGTEEDSEEDTEEDSEN
What are the official names of this protein?
Putative ankyrin repeat protein L66.
Protein: RECX_LEUCK
Sequence: MKTITKIAIQKRAGRYSIELDNQFAFGVAESVLIKYGLAKGRTLDEDLITQIKYDDAIAKALTIALNYLGHALRTTKQIKQKMRDKAVDEDIQAQVIAQLTQLGYVDDQNYANHYVATKKLITPKGPHVIRLALQQAGVAENMIEQALATYTFDEQCSIATKIAEKLAQGYQRESTRLRQQKMVQGLVNKGFSFETAQLVVDSMNIDNNAEDEQNNAKRQAEKLWHRYRHDESQQRFYKVKRQLYAKGFTSELIDAALLSLEQEEV
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMHA_YERPN
Sequence: MYHDLIRSELNEAADTLANFLKDDSNIDAIQRAAILLADSFKAGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHLSCVSNDFGYDYVFSRYVEAVGREGDVLLGISTSGNSGNIIKAIEAARAKGMKVITLTGKDGGKMAGSADIEIRVPHFGYADRIQEIHIKVIHILIQLIEKEMVKA
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KRCC1_MOUSE
Sequence: MKHSNKPYDSFQDELEDYIKVQKARGLEPKTCFRRMRGEYLESCGYREEFDSRPRYRMFDQRLPSGTNHSYPRSCSSSQTEDRVPQWLPAHDKIRLNSLSYCQFTRDGFSEKPVPLNLSQQEYNCGSYSVESVVHKRLCSEHSTIDPQVSHRQMHQKRKKHVEEGREKQEERPKHERKRSSEEMDLNKHRSIQRKKTKAETETVQDGTEKLKNRKEKKTRDVSSKKEDRKRRKEKKEQGEERTEEEMLWDQSILGF
What are the official names of this protein?
Lysine-rich coiled-coil protein 1.
Protein: PSMA3_STAAT
Sequence: MEFVAKLFKFFKDLLGKFLGNN
What is the function of this protein?
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
What are the official names of this protein?
Phenol-soluble modulin alpha 3 peptide.
What is the protein family that this protein belongs to?
Belongs to the phenol-soluble modulin alpha peptides family.
Protein: CCR2_HUMAN
Sequence: MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
What is the function of this protein?
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.
What are the official names of this protein?
C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, CCR2, Monocyte chemoattractant protein 1 receptor, MCP-1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane.
Protein: PAND_BACAC
Sequence: MFRTMMRAKLHRATVTEANLNYVGSITIDEDLMDAVNIVENEKVQIVNNNNGARLETYVIKGERGSGVVCLNGAAARLVQPGDKVIIICYGLVAEENIHKQEPKIAVLDDDNQIIEMLGAEKAGTIL
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETG_SYNJB
Sequence: MIEPILLGIVLGMVVVTLAGLFVAAYRQYQRSNKIGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RS12_HELPG
Sequence: MPTINQLIRKERKKVVKKTKSPALVECPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTSKFEVISYIPGEGHNLQEHSIVLVRGGRVKDLPGVKYHIVRGALDTAGVNKRTVSRSKYGTKKAKATDKKATDNKKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: LCL2_AJECH
Sequence: MVHIFTGILLGLLLLATGTQAQFQFFEQMFGGGQQQQHDSREQNVPSDSDWYQRTYDNARCSNYLCPGTLACVAVPHHCPCQHPAVEDKFELGDGSAICVSKGGFKFGEAARKVELARKGLL
What is the function of this protein?
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
What are the official names of this protein?
Long chronological lifespan protein 2.
What is the protein family that this protein belongs to?
Belongs to the LCL2 family.
Protein: ACCA_ALCBS
Sequence: MNPNFLEFEQPIADLEAKIEELRLVGSGSDINISEEVAKLQEKSITLTESIFRGLSSWQISQLSRHPKRPYMLDYIKRIFTDFDELHGDRAFSDDPAIIGGMTRLNGQPVMVIGHQKGREVKEKVRRNFGMPKPEGYRKALRLMEMAERFKLPVLTFIDTPGAFPGIDAEERGQSEAIARNLRVMSQLKTPILATVIGEGGSGGALAIGVCDHLQMLEFSTYSVISPEGCASILWRSADKAPEAAQAMGLTAGRLHELGIVDQVIKEPLGGAHRDYDQAADAIRKALAAQLESLCSMETDALINRRYERLMSYGNVVSDPADE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGK_ECO8A
Sequence: MYYGFDIGGTKIALGVFDSGRQLQWEKRVPTPRDSYDAFLDAVCELVAEADQRFGCKGSVGIGIPGMPETEDGTLYAANVPAASGKPLRADLSARLDRDVRLDNDANCFALSEAWDDEFTQYPLVMGLILGTGVGGGLIFNGKPITGKSYITGEFGHMRLPVDALTMMGLDFPLRRCGCGQHGCIENYLSGRGFAWLYQHYYHQPLQAPEIIALYDQGDEQARAHVERYLDLLAVCLGNILTIVDPDLVVIGGGLSNFPAITTQLADRLPRHLLPVARVPRIERARHGDAGGMRGAAFLHLTD
What is the function of this protein?
Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.
What are the official names of this protein?
N-acetyl-D-glucosamine kinase, GlcNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NagK subfamily.
Protein: CXP6_PARCG
Sequence: GWPAYPGSNGIRSSVCQKKLGCGSKNLASLGVCKAFCLGRKRFWQKCGKNGSSGKGSRICNPVLAHAVEKAGKGLIKVTDMAVATIIKFAG
What is the function of this protein?
Cytolysin that shows hemolytic activity (on bovine erythrocytes, HC(50)=5. 75 mg/ml).  This hemolytic activity is completely inhibited by small unilamelar vesicles composed of PC/PG, PC/PI and PC/PS in 1:1 molar ratios (with at least 100 mg/ml concentration).
What are the official names of this protein?
Parbolysin P6, Parbolysin 6.
What is the protein family that this protein belongs to?
Belongs to the worm cytolysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_LACLS
Sequence: MAISKEKKQEIIAQYARKEGDTGSPEVQIAVLTWEINHLNDHIKSHKKDHATQRGLMKKIGHRRNLLGYLRGKDVQRYRELIASLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: Y9435_DICDI
Sequence: MVKNGVLYLHLENIYQITIYKELPLEQKKLVDLGSLANWDIILLTKVLQAPYTKLNKSKLDIENKELLKIRLNYIKYENNLICKLEFDRDDDDLKELFKDKQVDSTLEVEKKVNKFKDIGNQYFTKKDYPEAVESYELA
What are the official names of this protein?
Uncharacterized protein DDB_G0289437.
Protein: RL27_BURM7
Sequence: MAHKKAGGSSRNGRDSESKRLGVKVYGGQAINAGGIIVRQRGTRMHAGENVGMGKDHTLFALVDGHVKFTTKGAAKKHTVVVVPAAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: KCTD8_MOUSE
Sequence: MALKDTGSGGSTILPISEMVSASSSPGAPLAAAPGPCAPSPFPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGGARRRGDLPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFPEKERLLREAEFFQLTDLVKLLSPKVTKQNSLNDECCQSDLEDNVSQGSSDALLLRGAAAGAPSGSGAHGVSGVVGGGSAPDKRSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFDRLSEAGFHMVACNSSGTAAFVNQYRDDKIWSSYTEYIFFRPPQKIVSPKQEHEDRKRDKVTDKGSESGTSCNELSTSSCDSHSEASTPQDNPANTQQAAAHQPNTLTLDRPSRKAPVQWMPPPDKRRNSELFQSLISKSRETNLSKKKVCEKLSVEEEMKKCIQDFKKIHIPDCFPERKRQWQSELLQKYGL
What is the function of this protein?
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response.  Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
What are the official names of this protein?
BTB/POZ domain-containing protein KCTD8.
What are the subcellular locations of this protein?
Presynaptic cell membrane. Postsynaptic cell membrane.
Protein: TDG_MOUSE
Sequence: MDAEAARSYSLEQVQALYSFPFQQMMAEVPNMAVTTGQQVPAVAPNMATVTEQQVPEDAPVQEPAPEAPKRRKRKPRAAEPQEPVEPKKPATSKKSGKSTKSKEKQEKITDAFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNADVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCNGEPCGIASNGLTAHSAEPRGEAAPSDVPNGQWMAQSFAEQIPSFNNCGTREQEEESHA
What is the function of this protein?
DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine (PubMed:21817016).  Cannot remove 5-hydroxymethylcytosine (5hmC).  According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC (PubMed:21722948).  Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches.  Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine.  In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T.  It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA.  It can also remove uracil and 5-bromouracil from mispairs with guanine.
What are the official names of this protein?
G/T mismatch-specific thymine DNA glycosylase, C-JUN leucine zipper interactive protein JZA-3, Thymine-DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OBG_STUS1
Sequence: MKFVDEVSIFVKAGDGGNGMMSFRREKFIEKGGPNGGDGGDGGSVYLEADENLNTLVDYRYTRRFQAQNGQKGGSTDCTGAKGEDLILPVPVGTTVIDAATQEIMGDLTKAGQRLLVAQGGWHGLGNTRFKSSTNRAPRQTTPGKPGDARDLKLELKVLADVGLLGLPNAGKSTFIRSVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVIADIPGLIEGASEGAGLGIRFLKHLARTRLLLHLVDMAPLDGSDPADAAEVILHELEKFSPALTQRDRWLVLNKADQLLEEEREERVRHVVERLDWKGPVFVISALESEGTEALSQAIMRYLDERAVRIAEEPEYAEALAELDRQIEDEARARLQELDDQRALRRAGVKSVEEADDDDFDDDDDDEGGAEIIYVR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Protein: UNC58_CAEEL
Sequence: MFFYSPNVAPQPSSTSHRRPTLTHQHHLHVGHLDTRLSVQIPEILSRSLVHDPERTRLVPEQLRFIIDENQELWTGSQPPTGFLELCASPVSSVFSNADARRMSQRKLVLRRPTISIQEDGKIIIDHVTARWEGANINSQSALLDADDGATVITDTIKDDQDDKEPKSCPQQTVKYIKILTPHVILVSVLIGYLCLGAWILMLLETRTELLARSKKLVRLTNLMSNFTAESWKMLNNAQHGVSNMDEGEWAATFREWMVRVSETVDDRRPIRRELNRPDDLSNMHNKWTFPTAILYVLTVLTTCGYGEVSVDTDVGKVFSVAFALVGIPLMFITAADIGKFLSETLLQFVSFWNRSVRKVKQWMSRIRHGRRKSLQSTGGPNDTLDILGVDGTEEKLWFPIGAYVSCICIYCSIGSAMFITWERTWSFIHAFHFGFNLIVTVGLGDIVVTDYIFLSLIVAFVIVGLSVVTMCVDLASTHLKAYFTRIHYFGRAKRFLGMSEELKEIVALLGAMRRKKGGKVTWNDVRDFLDNELRDRPFEPHELLMKLRFIDETSSGMSTIRHNSFQSDFFRESEYIRRVAALRPEQPAYL
What is the function of this protein?
Has a role in mobility, possibly in the transport of potassium in muscles.
What are the official names of this protein?
Uncoordinated protein 58.
What is the protein family that this protein belongs to?
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DEF2_CAPAN
Sequence: MAGFSKVIATIFLMMMLVFATGMVAEARTCESQSHRFKGLCFSKSNCGSVCHTEGFNGGHCRGFRRRCFCTRHC
What is the function of this protein?
Plant defense peptide with antifungal activity against F. oxysporum and B. cinerea.
What are the official names of this protein?
Defensin J1-2.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: CDSA_STAAR
Sequence: MKVRTLTAIIALIVFLPILLKGGLVLMIFANILALIALKELLNMNMIKFVSVPGLISAVGLIIIMLPQHAGPWVQVIQLKSLIAMSFIVLSYTVLSKNRFSFMDAAFCLMSVAYVGIGFMFFYETRSEGLHYILYAFLIVWLTDTGAYLFGKMMGKHKLWPVISPNKTIEGFIGGLFCSLIVPLAMLYFVDFNMNVWILLGVTLILSLFGQLGDLVESGFKRHFGVKDSGRILPGHGGILDRFDSFMFVLPLLNILLIQS
What are the official names of this protein?
Phosphatidate cytidylyltransferase, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COX3_ALLMA
Sequence: MTKKLINQFKSFQVHPYHLVEPSPWPLGASVACLILTLGGVMKFHGFAAGDIGLPLGLILVLASMLLWWRDVIREATYQGHHTKTVKYGITLGVVLFIVSEILLFFSLFWAFFHSSLAPSVELGSTWPPVGIEPLNPFEVPLLNTIILLTSGCTITVSHAKIISGDRGATILYLILTILLAWMFLGLQWVEYVNAPFTIADSVYGSTFFVATGFHGLHVMIGTIFLTVSLNRILSYHLTSGHHLGYEAAIWYWHVVDVIWLFLYVSVYYWGSNV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.