PharMolix/UniProtQA huggingface dataset:
Protein: ATP8_EQUAS
Sequence: MPQLDTSTWFINIVSMILTLFIVFQLKISKHSYPMHPEAKTTKMAKRLTPWESKWTKIYSPLSLPQQ
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: DNLJ_TREPS
Sequence: MSTAQRRVQELEKLILHHQDRYYNAESDISDDAFDALWEELARLDPGNPLLKAIGSDSQRDAVKKRHIVPMGSQHKAADEESFSAWAKKNALQAFLVQHKLDGVSLELQYERGHFCCALTRGNGIVGDDVTANVRGMRGFVPTLTAEWGPCGNLPFTGGVRGEVIMHKDIHRSHYPTHANCRNTVNGILKRKDGRGRTHLHIVCYDAVPGTPGKPFTGSLPFADETEKLAWLARQGFVTVHSHRCANAQEVVALRSEIMRTRELLPYSIDGLVVKSTDLDFQDAQLPRPKKQIAFKFSTQEAITTLRDVQWQTSGVTYTPIGITDPVRLAGTTVKRANLCNPNMLTKLCLKIGSHVLISKRGEIIPKIEALVSTPAHAQEIHIPTQCTSCNTVLENSGSRLFCPNVNCPLLSHHRITRWIECLEIKHVGTELIQRLFEEKKVRRIPDLYTLTCEDLIEIEHVGNATAKKILEAIHHKKEIALQTFIAGFGIEGIGETMGEKLICAGFDTLEKVLHATTETLESIYQFGTELAKSVVTGIARVKDDMCELLDRGFVRILAKQQAESPLRGKSFCFSGSLRNGDRATIHRIRALGGVVRTSVTRDLSYLIFESLSQPYRTAQKLKKEQGVALEIISEDEFCRLLDQASASCTHTGETVHPLQGKSFYFSGASRSMNHKHAQEKVRALGGDVASSVTAQLDYLVFYSQSTRYRTACALGIQIISEETLHKLIATAQSPLHTDAHVHAPLHGMSFCFSGDLDGMTRAQAIALVQRLGGTVKTAVSTQLTYLVSNDPHGQSRKCQNAVRCGVRIISEHVFLALCTPGT
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: UT023_PEA
Sequence: ADLIERRQRSEFQFSAVGLGPRTDYEVDILTTFTKLNYEAYTYPR
What are the official names of this protein?
Unknown protein from spots 23/28/205 of 2D-PAGE of thylakoid.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid.
Protein: LIPA_CITBB
Sequence: MDPIRKPAWLQKKIIPAAHAEMEGLLKELRLNTVCQQARCPNITECFGKRQATFLILGRICTRLCSFCSVSKETPLPLEPGEAASVAEAVKRLGLSHVVITSPTRDDLPDGGASVYAETVARIRSVSPATKVELLIPDFRGDWAALAAVVESAPDILGHNLETVPRLYSIRSGADYRRSLDLLAQARRMAPGLNTKSGLMLGLGEEEAELFAVMEDLLKAGCGYLSLGQYLAPSRMHHPVQRYVEPELFERYKERALTMGFEHVESAPYVRSSYHAENYLESKFPPPEGEG
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSR1_YEAST
Sequence: MSFDRQLTEDQEVVLKQIWTHLFHLWQVPVDGTHIFPNNSLHSSSTPAKKKKSSWFSKLQSSDHTQDSSEAAEAAHLYEKGKIHKALANLDPQTTKKQFWHDIKNETPDATILKFIRARKWNADKTIAMLGHDLYWRKDTINKIINGGERAVYENNETGVIKNLELQKATIQGYDNDMRPVILVRPRLHHSSDQTEQELEKFSLLVIEQSKLFFKENYPASTTILFDLNGFSMSNMDYAPVKFLITCFEAHYPESLGHLLIHKAPWIFNPIWNIIKNWLDPVVASKIVFTKNIDELHKFIQPQYIPRYLGGENDNDLDHYTPPDGSLDVHLKDTETRAMIEKEREELVEQFLTVTAQWIEHQPLNDPAYIQLQEKRVQLSTALCENYSKLDPYIRSRSVYDYNGSLKV
What is the function of this protein?
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity.  Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase.  Modulates ArfGAP function through effects on SPO14 activity.  Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1).  May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress.  Inhibits fatty acid synthase activity in response to heme depletion and oleic acid starvation, preventing saturated fatty acid (SFA) accumulation (PubMed:17803462).
What are the official names of this protein?
Phosphatidylinositol transfer protein CSR1, CHS5 SPA2 rescue protein 1, SEC14 homolog protein 2.
What is the protein family that this protein belongs to?
Belongs to the PITP family.
What are the subcellular locations of this protein?
Cytoplasm. Microsome. Endosome.
Protein: TYSY_STAAT
Sequence: MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYKGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_BACC0
Sequence: MNEMTHRTKTRPVKVGNLTIGGNNELIIQSMTTTKTHDVEATVAEIKRLEEAGCQVVRVAVPDERAANAIADIKKQINIPLVADIHFDYRLALKAIEGGIDKVRINPGNIGRRHKVEAVVNAAKERGIPIRIGVNAGSLERHILEKYGYPTADGMVESALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAARAFDYPLHLGITESGTLFAGTVKSAAGLGAILNKGIGNTLRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRIEIDLISIANEVEEYISTLQVPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGQVVRKVPEEIMVEELKKEIDVIAAEMAAEREKEKETQEQ
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: TRHO_AYWBP
Sequence: MTKTSNSSYLVILYYQYVPIKDPQTFRNQHFKYCESLGLLGRIIVAQEGINGTLSGPKEQIHKYIDQLKQDVRFCNTVFKIENVDAQVFPRLSIKVKPELVNLSLEEKVDLTKDKGAYLAPQEFLQALQEKDVLILDARNDYEYDLGHFRNAVNPNIRHFRDLPNWVKQNTHLLKNKKIVTYCTGGVRCEKFSTFLKKEGFVDVYQLEGGIISYGKHPETQGVLWDGQMYVFDQRIAVTVNQKEHVIVGKDYFDGTPCERYINCSNPQCNKQILCHEHNEHKYLGACSDKCSAHPQNRYLKKHNNKTS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: RTXC_VIBCH
Sequence: MSITHQPANLTLAQIQQMIGGVMLLSQHSPLHRRYVVAEWLQRILPAFELNQFCYYEDEHGRPIAFCNWAFVSEQIRDELLSGVREISPSDWRSGQQIYIPEMIAPFGHGREVVNDLRRRVFLPWQGQKVCTVRGKVDAQNDRCIRKVQWFSI
What is the function of this protein?
Catalyzes fatty acylation of the protoxin (RtxA) at internal lysine residues, thereby converting it to the active toxin.
What are the official names of this protein?
Lysine-acyltransferase RtxC.
What is the protein family that this protein belongs to?
Belongs to the RTX toxin acyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_CALFL
Sequence: MEELQGYLEIDGFRQHHFLYPLLLQEYIYALAHDHGLNGSILSEHMENLSHDNKSSSLIVKRLITRMHQQNHFIISVNDSNQKGFVGHNKNFHSQKISEGFAVIVEIPFSLQLVSSLEEKEIAKFHNSRSIHSIFPFFEDKLSHLNHVSDILIPYPIHLEILVQTLRCWIQDAPSLHLLRFFLHEYWNSNSLITPKKSISFFSKENQRLFLFLYNSHVYECESVFIFLRKQSSHLRSTSFGSFLERTHFYGKIEHLVVVLGNDFPKTLWLFKDPFVHYVRYQGKSILASRGTQFLIKKWKYHLVNFWQCHFYLWSQPDRIHLNQLCNHSFYFLGYLSSVQLNSSVVRSQMLENAFRMDTAIKKFETIVPIIPLIGSLAKAKFCNGSGHPISKPFRTDLSDSEIINRFGRICKNLSHYHSGSSKKQSLYRIKFILRLSCARTLSRKHKSTVRAFLKRLGSELLEEFLTEEEQVLSLLFPRTPSHRPHRERIWYLDIICINDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MDH_CERSK
Sequence: MARPKIALIGAGQIGGTLAHLAAIKELGDVVLFDIAEGTPQGKALDIAQSGPSEGFDAVMKGANSYEEIAGADVCIVTAGVPRKPGMSRDDLIGINLKVMKSVGEGIKAHAPNAFVICITNPLDAMVWALQQFSGLPAEKVVGMAGVLDSARFRHFLSVEFNVSMRDVTAFVLGGHGDTMVPLVRYSTVAGIPLPDLVQMGWTTQEKLDQIVQRTRDGGAEIVGLLKTGSAFYAPATSAIEMAEAYLKDQKRLLPCAAYVDGAFGLNGMYVGVPTIIGAGGIEKIVDIKLNDDEQAMFDKSVNAVKGLVEACKGIDSSLA
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: HBB_MACNE
Sequence: MVHLTPEEKNAVTTLWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSSPDAVMGNPKVKAHGKKVLGAFSDGLNHLDNLKGTFAQLSELHCDKLHVDPENFKLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: NEUM_RAT
Sequence: MLCCMRRTKQVEKNDEDQKIEQDGVKPEDKAHKAATKIQASFRGHITRKKLKDEKKGDAPAAEAEAKEKDDAPVADGVEKKEGDGSATTDAAPATSPKAEEPSKAGDAPSEEKKGEGDAAPSEEKAGSAETESAAKATTDNSPSSKAEDGPAKEEPKQADVPAAVTDAAATTPAAEDAAKAAQPPTETAESSQAEEEKEAVDEAKPKESARQDEGKEDPEADQEHA
What is the function of this protein?
This protein is associated with nerve growth.  It is a major component of the motile 'growth cones' that form the tips of elongating axons.  Plays a role in axonal and dendritic filopodia induction (By similarity).
What are the official names of this protein?
Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, Protein F1.
What is the protein family that this protein belongs to?
Belongs to the neuromodulin family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, axon. Cytoplasm. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.
Protein: TM192_RAT
Sequence: MAAGGRLEDGSLDILQSTDDDPLLDTQPLPHHSLHAHFRPRFHPLPTVIIANLLLLIHVVFVTLAFLTGVLCLYPDPNEDKCPENYTNPLKVQTAIILGKVILWILHLLFERYIQYHHRKVRSRGYSQIYRSTRHLKALALTIHSSGNTALLLLLCVQYSFPEPNKLYLELILAVLALELICSLSCLVLYTVKIRRFNKAKPQPDVLEEEKCYAYPSNIASETGFRTVSSLEEIVEKQGDIIVYLKRHNALLSKRLLELATQPART
What are the official names of this protein?
Transmembrane protein 192.
What is the protein family that this protein belongs to?
Belongs to the TMEM192 family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Late endosome.
Protein: COTB3_STRMJ
Sequence: MRERGPVTPAKSSAPPERPWTTGTAPGSVPLLGHTMALWRRPLQFLASLPAHGDLVEVRLGPSRAYLACHPELVRQVLLNPRVFDKGGVFDKARQLLGNSLSVSRGEDHRYQRRMIQPAFHTPKIAAYTAAVADDTRAAIGSWEPGRTLDISDTMHALLMRVAARTLFSTGIDEATIDEARHCLRIVSDGIYKRTMAPLGIMEKLPTPGNRRYDRANARLRQIVDEMIRERRRSGADHGDLLSTLLRAEHPETGKGLDDGEVLDQVVTFLVAGSETTASTLAFVFHLLGAHPEVEKRVHAEIDEILEGRSPTFEDLPSLEYTRGVITESLRLYPPSWMAMRVTAAETELGGRTVPAGTMILYSAQALHHNPELFPDPERFDPERWLGDRAKEVERGALLPFGAGSHKCIGDVLALTETALIVATIASRWRLRPVPGTTLRPEPKATLEPGPLPMVCEPR
What is the function of this protein?
Involved in the biosynthesis of cyclooctatin, a potent inhibitor of lysophospholipase.  Catalyzes the stereospecific hydroxylation of cyclooctat-9-en-7-ol to form cyclooctat-9-ene-5,7-diol.
What are the official names of this protein?
Cyclooctat-9-en-7-ol 5-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: GLNB_SYNE7
Sequence: MKKIEAIIRPFKLDEVKIALVNAGIVGMTVSEVRGFGRQKGQTERYRGSEYTVEFLQKLKLEIVVEDAQVDTVIDKIVAAARTGEIGDGKIFVSPVDQTIRIRTGEKNADAI
What is the function of this protein?
P-II indirectly controls the transcription of the GS gene (glnA).  P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA.  When P-II is phosphorylated, these events are reversed.  In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.
What are the official names of this protein?
Nitrogen regulatory protein P-II, PII signal transducing protein.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
Protein: LPXD_BORBR
Sequence: MPVLLDPENALALDVLLAGTDAQGLDWHLSAPDAADLPRIRGIGTLSSAGSEEISFLSNPRYQNQLATTRAAAVIVTPDVAQARQEQGASGHVLVVCKHPYLLYARLAQWFERASRPAGPAGVHPSAVVDPSAEIDADARVGAQCVIEAGARIGRGARLGPGCVIGAGSTVGADSLLHPRVTLYAGVHVGERAIIHSGAVLGADGFGFAPDPTLGRGAWGKIPQLGGVRVGNDVEIGANTTIDRGALDDTIVGDGVKLDNQIMVAHNVRIGAHTAIAACVGIAGSTTIGERCTIGGASMLSGHLAIADDVNISGGTAVTSNIAKAGRYTGVYPYAEHSEWQRNAAVIQQLALLRRRLRALERE
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: GLMS_THET8
Sequence: MCGIVGYVGFRNATDVLLDGLRRLEYRGYDSAGIAVRTPEGLKVVKRSGKLSALAEAVGKTPLQGALGIGHTRWATHGAPTDPNAHPHTTEDGRIALIHNGIFENYLELKEALEARGHRFRSETDTEVLAHLLEETYRGDLLEALREALKAVRGAYAVVVAHEDHEEIVAARTVSPLVVGLGEGENFLASDVPALLPYTRRVLFLHDGDVVRLTREGVEITDLEGRPVQREAVEVDWTLEAAEKGGFPHYMLKEIYEQPWVLENTLGGRLREEEGTVELGLALDPREVDRVHVIACGTASYAGLYGKYLLETLARLPTEWDVASEYRYRDPVVDSRTLALAISQSGETIDTLEGLREAKRKGARSLGVINAKGSTLTREVEDVLYIHAGPEIGVASTKAYTAMLAAMALLAVWFGRGRGALALEEAQRLLREMRRLPRLVEEVLEKRPLVAHVAEKYHQARDFLFLGRHVQAPTAYEGALKLKEISYIHAEAYPAGEMKHGPIALIDEHLPVVVLATKGPLYEKTLSNIQEVRARGGKVIAIATEGDEEIPRLAQDVIYVPEVHPLLAPIVSVVPLQLLAYEIAVLLGRDVDQPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_GLOVI
Sequence: MFLRSVQLHDFRNYAEADLELTSPKTILVGDNAQGKSNLLEAVQLLATGRSTRALRDRELIARGKEQARVAATVERLGDTVELEMILRAGKRRTVRVGGETRRTQVEALGYLHCVSFSSLDLDLVRGAPETRRDWLDGILLQLEPVYTNVLAQFVQALHQRNALLRSTELSPDALAEQLPCWDDLLVRAATPVMRRRHRLIERLAPLARRWHGSISGGRETFAVRYQPQISFEQEDAQSVQQALQELLKEKRTLEGRRGTSLVGPHRDEVDLSIDEIPARQFGSQGQQRTLVLALKLAELELLEQVTGEVPLLLLDDVLAELDLHRQDQLLGAIQERVQTIVTTTHLSLFDSQWLQSATVLTIEKGRIGSPPAPA
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCL8_CANLF
Sequence: MKFSTALLCLLLTAASFSTFVLAQPDSVSIPITCCFSMVKRKIPMQKLESYMRITNSQCPQEAVIFKTKASREICADPKQKWVQDYMNHLDQKSQAQKP
What is the function of this protein?
Chemotactic factor that attracts monocytes.  This protein can bind heparin (By similarity).
What are the official names of this protein?
C-C motif chemokine 8, Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2, MCP-2, Small-inducible cytokine A8.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP23_XENLA
Sequence: MEEKKPEQDEFGYHLFPERGNGESKKNSILSKSLFSFNHKCQLMLKIALDTSPYAKLLLDAMKQSGCTVYKDRHFSCEECDGSVSGGFDAATSEIVLCQNNIHQQSHMNRVVTHELIHAFDHCRAHVDWFNNVRHLACSEIRAANLSGDCTLANELTRFKFGVKGHHQVCVRDRALRSILAVRNISRETAEKAVDEVFDSCFNDHEPFGRIPHSKADAKFAYRDFQNRDRYYANL
What are the official names of this protein?
Mitochondrial inner membrane protease ATP23 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M76 family.
Protein: DHG2_BACSU
Sequence: MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSGADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMPHEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYSTSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAFGKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE
What are the official names of this protein?
Glucose 1-dehydrogenase 2, GLCDH-II, GDH-II, General stress protein 74, GSP74.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: DSZC_RHOSG
Sequence: MTLSPEKQHVRPRDAADNDPVAVARGLAEKWRATAVERDRAGGSATAEREDLRASGLLSLLVPREYGGWGADWPTAIEVVREIAAADGSLGHLFGYHLTNAPMIELIGSQEQEEHLYTQIAQNNWWTGNASSENNSHVLDWKVSATPTEDGGYVLNGTKHFCSGAKGSDLLFVFGVVQDDSPQQGAIIAAAIPTSRAGVTPNDDWAAIGMRQTDSGSTDFHNVKVEPDEVLGAPNAFVLAFIQSERGSLFAPIAQLIFANVYLGIAHGALDAAREYTRTQARPWTPAGIQQATEDPYTIRSYGEFTIALQGADAAAREAAHLLQTVWDKGDALTPEDRGELMVKVSGVKALATNAALNISSGVFEVIGARGTHPRYGFDRFWRNVRTHSLHDPVSYKIADVGKHTLNGQYPIPGFTS
What is the function of this protein?
Catalyzes the first step of the '4S' desulfurization pathway that removes covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds.  Sulfur dioxygenase which converts DBT to DBT-sulfone (DBTO2 or DBT 5,5-dioxide) in a stepwise manner.  In (PubMed:7961424) DBTO (dibenzothiophene-5-oxide) was reported not to be a substrate, in (PubMed:7574582, PubMed:9634856, PubMed:8824615, PubMed:9308179) it is reported to be a substrate (PubMed:7961424, PubMed:7574582, PubMed:9634856, PubMed:8824615, PubMed:9308179).  Can also use benzyl sulfide and benzyl sulfoxide as substrates, although benzyl sulfoxide is a poor substrate (PubMed:8824615).  The pathway substrate specificity has been augmented using mutagenesis, however no mutations allowed use of alkylated thiophenes (PubMed:11823208).
What are the official names of this protein?
Dibenzothiophene monooxygenase, DBT monooxygenase, DBT-MO, DBT sulfur dioxygenase, Dibenzothiophene desulfurization enzyme C, Sulfide/sulfoxide monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the DszC flavin monooxygenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HELX_RHOCB
Sequence: MAKPLMFLPLLVMAGFVGAGYFAMQQNDPNAMPTALAGKEAPAVRLEPLGAEAPFTDADLRDGKIKLVNFWASWCAPCRVEHPNLIGLKQDGIEIMGVNWKDTPDQAQGFLAEMGSPYTRLGADPGNKMGLDWGVAGVPETFVVDGAGRILTRIAGPLTEDVITKKIDPLLAGTAD
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Also acts as a disulfide oxidoreductase in cytochromes c biogenesis.  The cysteines of apocytochromes c must be in the reduced state for covalent linkage between the two moieties to occur (By similarity).
What are the official names of this protein?
Thiol:disulfide interchange protein HelX, Cytochrome c biogenesis protein HelX.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbE subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: IF2A_DICDI
Sequence: MVFENDCRMYEKKYPEENELVMVRIESIGDMGVYVSLLEYNNIEGMILLSEISRRRIRSINKLVRVGKTEAVVVVRVDKDKGYIDLSKRRVTPEEYAQCEERFHKSKAVHGIVRYVATKLSTEDNVVKTKHLYTKFVWPLYTKYGHAYEAFKLSITEPSVFNGFDIAENERKVLMETIIQKLKPQPHKVRADLEITCYDYEGIDAIKHAITASQNHALSVLKAPEDGKFDEKAFGVVTIKLVAPPLYVMVGTFDEKEKGLSMVGQCVDVLSEEITKKNGNLTIKAAPRIVGAVDDQELRDLMEQLEVENQDGDGEEHEDDDDDDDDEEEEEKPKEKKSSRK
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.  This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex.  Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex.  In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
What are the official names of this protein?
Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-alpha family.
Protein: KU70_EMENI
Sequence: MADDYREDDVVEEEEELDEAPRPSADPKRQSYESPATAALKCAYHLMQQRIISNPRDMIGVLLYGTKQSKFYDEDENSRGDLTYPNCYLFTDLNIPSAHEVLELRSLVQDEENAKKILEPSNEPVSMANLLFCVNQIFTLKAPNFLSRRLFIVTDNDNPHGDNKSFRSAATVRAKDLYDLGVTIELFPISQIEHEFDTSKFYDDIIYKASPNDPDAPAYLKPDAKMNDAQDGISLLNGLLSSINSRSVPRRAQFSNMSLELGPNFKISVSGYILFKRQESARSCYVWLGGEKPQIAKGVTTQIADDSARTIEKWEIKKAYKFGGDQVCFTPEEQKSLKDFGEPVIRIIGFKPLSTLPFWANIKHPLFIYPTEEDYVGSTRVFSALYQKLLRDQKVALVWYIARKAASPVLGAMMAGEEKVDENGIQKIPPGMWIIPLPFADDVRQNPETALQVAPEPLIDQMRTVIQQLQLPKGVYDPQKYPNPSLQWHYRILQALALDEDVPEKPDDKTIPKYRQIDKRAGGYVLDWADELEKQYAKITADQPKSTTLAKRPAKADNPDKAAPPAKKVKAEAGSGNIQDEVQKHFEQHTLSKLTVATLRDFLASQGRATAGKKAELLERVEELLETKF
What is the function of this protein?
Single-stranded DNA-dependent ATP-dependent helicase.  Involved in non-homologous end joining (NHEJ) DNA double strand break repair.  DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA.  Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection.  Required also for telomere recombination to repair telomeric ends in the absence of telomerase.  ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase.  Involved in telomere maintenance.  Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement.  Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere.  Required for mating-type switching (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit Ku70.
What is the protein family that this protein belongs to?
Belongs to the ku70 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.