PharMolix/UniProtQA huggingface dataset:
Protein: ARP1_METAQ
Sequence: MQNLTDKGAIIFGVQKTSQFANGETATADWVDYHSPFNPRGDGYQDPATSSAGAGSSIASYEWLDLAAGSDTGGSIRGPAAVQGIFGNRPSHGLISLDNAMPLSPKLDTPGFLARDPYLWNAANAALYRENPLSRWSWGDSQPSSILSRNKTLFMNWFNENILPRSSDPLTCSSGLLLHVDGSAGFISRNGYINPPVPPFGFSNGQISVFAETPDSVFPLGQVPAFSSITNHTEYLPVTINVVAAKGCDVLIAKLAEDMVAAGILKVLKIGAGIEGGEILMRRYFVRDDGDEVMSRITSRGRLLFQDWDRLRGILAPTLYVDYTKIGKGKWEAMSADDFMAMVSNDDFLGDLCVKTQHLIGATSWERVSESKVVGHHQLRAAHQVYTSPDLKTVKLRGHSHATNEHYYVKSDGVWKFAGLKPEVRWNEHKFEEVFKGSYTQSEKHS
What is the function of this protein?
Scytalone dehydratase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster (PubMed:29958281).  The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified (PubMed:29958281).
What are the official names of this protein?
Scytalone dehydratase-like protein Arp1.
What is the protein family that this protein belongs to?
Belongs to the scytalone dehydratase family.
Protein: B3GTJ_ARATH
Sequence: MRKPKLSKLERLEKFDIFVSLSKQRSVQILMAVGLLYMLLITFEIPFVFKTGLSSLSQDPLTRPEKHNSQRELQERRAPTRPLKSLLYQESQSESPAQGLRRRTRILSSLRFDPETFNPSSKDGSVELHKSAKVAWEVGRKIWEELESGKTLKALEKEKKKKIEEHGTNSCSLSVSLTGSDLLKRGNIMELPCGLTLGSHITVVGKPRAAHSEKDPKISMLKEGDEAVKVSQFKLELQGLKAVEGEEPPRILHLNPRLKGDWSGKPVIEQNTCYRMQWGSAQRCEGWRSRDDEETVDGQVKCEKWARDDSITSKEEESSKAASWWLSRLIGRSKKVTVEWPFPFTVDKLFVLTLSAGLEGYHVSVDGKHVTSFPYRTGFTLEDATGLTINGDIDVHSVFAGSLPTSHPSFSPQRHLELSSNWQAPSLPDEQVDMFIGILSAGNHFAERMAVRRSWMQHKLVKSSKVVARFFVALHSRKEVNVELKKEAEFFGDIVIVPYMDSYDLVVLKTVAICEYGAHQLAAKFIMKCDDDTFVQVDAVLSEAKKTPTDRSLYIGNINYYHKPLRQGKWSVTYEEWPEEDYPPYANGPGYILSNDISRFIVKEFEKHKLRMFKMEDVSVGMWVEQFNNGTKPVDYIHSLRFCQFGCIENYLTAHYQSPRQMICLWDKLVLTGKPQCCNMR
What is the function of this protein?
Possesses hydroxyproline O-galactosyltransferase activity.  Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs).  Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues.  Utilizes UDP-galactose solely as sugar donor.  The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition.  AGP glycans play essential roles in both vegetative and reproductive plant growth.
What are the official names of this protein?
Hydroxyproline O-galactosyltransferase GALT6, Beta-1,3-galactosyltransferase 19.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: AIS_SALPB
Sequence: MLAFTLRFIKNKRYFAILAGALVIIAGLTSQHAWSGNGLPQINGKALAALAKQHPVVVLFRHAERCDRSDNTCLSDSTGITVKGAQDARALGKAFSADIQNYNLYSSNTVRTIQSATWFSAGRSLTVDKKMMDCGSGIYASINTLLKKSQNKNIVIFTHNHCLTYIAKNKRGVKFDPDYLNALVMHAENGKLFLDGEFVPG
What is the function of this protein?
Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core.
What are the official names of this protein?
Lipopolysaccharide core heptose(II)-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. Ais subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: CYSQ_ECOLI
Sequence: MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDVPVLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPGFRVSIY
What is the function of this protein?
Converts adenosine-3',5'-bisphosphate (PAP) to AMP.  May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS).  Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2).
What are the official names of this protein?
3'(2'),5'-bisphosphate nucleotidase CysQ, 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase, 3'-phosphoadenosine 5'-phosphate phosphatase, PAP phosphatase, DPNPase.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily. CysQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DCTA_CUPTR
Sequence: MRKPFYKILYVQVLFAICIGILLGHFWPDTGVAMKPLGDGFIKLIKMIIGPIIFCTVVTGIAGMSDMKKVGRVGGKALLYFEVVSTFALLIGLGAAHLLKPGVGFNIDPATLDTKAIAQYVSKAHGQSTVEFLMHIIPDTVFSAFANGDILQILLVSLFFGAALAVLGERARIVVQLIEQVSKVFFHIVHVITKVAPIGAFGAMAFTIGKYGLGSLVPLLKLIGTFYFTAIVFVLVVLGTIARMTGFSIVRFIAYIKEELLIVLGTSSSEAALPHMMEKLEKLGCSKSVVGLVVPTGYSFNLDGTNIYMTMAVIFIAQATGIELTLMQQLTILAVAMITSKGASGVTGSGFITLAATLAVVPTIPVAGMVLILGIDRFMSECRALTNIIGNGVATVVVSAWERELDRKRLARVLQHGAGDDADTLGEAGQRAA
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DCE2_PIG
Sequence: MASPGSGFWSFGSEDGSGDPENSGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRTTSRKATCACNQKPCNCPKAEVNYAFLHATDLLPACDGERPTLAFLQDVMDILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMLIARFKMFPEVKEKGMAAVPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQSCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYVPPSLRVLDNNEERMSRLSKVAPVIKARMMESGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL
What is the function of this protein?
Catalyzes the production of GABA.
What are the official names of this protein?
Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, GAD-65, Glutamate decarboxylase 65 kDa isoform.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasmic vesicle. Presynaptic cell membrane; Lipid- anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters (By similarity).
Protein: YBEY_CLOP1
Sequence: MIFIDNRQNKFEVTEELTKKLEEVISFVLKEEKVKEDCEVSLVFVDNEEIRGINNETRGIDRATDVLSFPMIDYPEDKVYKDVYLEHEFDKCYFDGDELILGDIVLSLERTKEQSIEFNHSFEREACYLVTHSVLHLLGYDHMEEEEKARMRGREEELLGKLNITRES
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_CAUSK
Sequence: MVDQAYEPRLKSEYRARIRAAMKEQFAYTNEMQIPKLDKIVLNMGIGEAVADSKKAQTALKDLMAIAGQKPVATKARKSIAGFKLREGMVVGAKVTLRKDKMYEFLDRLVTIALPRVKDFRGLNGKSFDGRGNYAMGLKEHLVFPEINYDQIEQIWGMDIIVCTTAKTDQEAKALLKEFQFPFTN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: PAR15_HUMAN
Sequence: MAAPGPLPAAALSPGAPTPRELMHGVAGVTSRAGRDREAGSVLPAGNRGARKASRRSSSRSMSRDNKFSKKDCLSIRNVVASIQTKEGLNLKLISGDVLYIWADVIVNSVPMNLQLGGGPLSRAFLQKAGPMLQKELDDRRRETEEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSWQIMANIIKKCLTTVEVLSFSSITFPMIGTGSLQFPKAVFAKLILSEVFEYSSSTRPITSPLQEVHFLVYTNDDEGCQAFLDEFTNWSRINPNKARIPMAGDTQGVVGTVSKPCFTAYEMKIGAITFQVATGDIATEQVDVIVNSTARTFNRKSGVSRAILEGAGQAVESECAVLAAQPHRDFIITPGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQRKYTSVSLPAIGTGNAGKNPITVADNIIDAIVDFSSQHSTPSLKTVKVVIFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTCNLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA
What is the function of this protein?
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:16061477, PubMed:25043379, PubMed:25635049).  Acts as a negative regulator of transcription (PubMed:16061477).
What are the official names of this protein?
Protein mono-ADP-ribosyltransferase PARP15, ADP-ribosyltransferase diphtheria toxin-like 7, ARTD7, B-aggressive lymphoma protein 3, Poly [ADP-ribose] polymerase 15, PARP-15.
What is the protein family that this protein belongs to?
Belongs to the ARTD/PARP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTND_BACMK
Sequence: MAQIRIHEENTRIENEVEVSNFLQGEDVLYEKWNISKLPTHLKENYSLTDENKAEILTLFSKEIADVSERRGYKAYDVVSLSNSTPNLDELLINFQKEHHHTDDEVRFIVSGHGIFAIEGKDGRFFDVELEPGDLISVPENARHYFTLQDDRQVVAIRIFVTTEGWVPIY
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: RL18_HALVD
Sequence: MATGPRYKVPMRRRREVRTDYHQRLRLLKSGKPRLVARVSNKHVRAQLVTPGPQGDETHAAATSADLDEYGWEAPTGNLPSAYLTGYLAGKRALAAGVEKAVLDIGLNTATPGNKVFAVQEGAIDAGLEIPHNDAVLADWDRNRGVHIAEYAEQLDEPLYSGEFDATNLPDHFDEVLGNLQEDE
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18, HVOL18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PATL1_XENLA
Sequence: MESLVDGDGFPDLEEDEDIDQFNDDTFGAGAVDDDWREEHERLAEMEEKLPATHILARVTSSPINDLLGDQQEELEQSLNQLVRENEEPALPQGSLTQFSAGMNSSIWDTSRTIRPIRGPLLMEDMTPLSILHEYGLATVAPPGRDDTERDASERALPRRSTSPVIGSPPVRAVPIGTPPKHGASPNFSHTQVLCPNPIHIRASSAFSGPHNNPASILRHPFPSALSPLQRAQLLGGAQTVAAQMSPSQFSRPGLHGPTLASVAPKLLQGHVGQMVAPVGGGFRPFFGVPSAPGAHIKNMSLRSQQQFRPDTTHLHPQHRRMLYQRQQNRNQHRGVNGSGGERTCRPAQMELNRRDPYAGLMLQREKEWVCRIQLLQLQSTDPYHDDYYYQNYFEKLDKLSVSQDRSREGPKKERTKLITPQVAKLEHTYKPVQFEGSLGKLTVSSVNNPRKMIDAVATSRSEEDETREKQVRDKKRQTLVIIEKMFSLLLDLEDFERRFSLCCEEAEHEVLTEEQKQKLQQLCDTLRGKEVGERVAEEQFVQIMCIRKGKRMISRILPLLPLQLAAAVLSIMAHNLLFLIKKDIQDQALPCLAATCSLVLCQLSLPALTSLLQNLCGATSQQQLSSILQNKFGLTLLYQILERGEDLLSSGDPMSQSQPTWTSLVVQAAHCLLQVSELSLPRPLCSPLTALAHFSRYLDTQNSSLLQSKLGSTNGTL
What is the function of this protein?
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs.  Acts as a scaffold protein that connects deadenylation and decapping machinery.  Required for cytoplasmic mRNA processing body (P-body) assembly (By similarity).  When tethered to a reporter mRNA, able to repress translation (PubMed:20826699).
What are the official names of this protein?
Protein PAT1 homolog 1, PAT1-like protein 1, Protein PAT1 homolog b, Pat1b, xPat1b.
What is the protein family that this protein belongs to?
Belongs to the PAT1 family.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus.
Protein: RL29_STRGC
Sequence: MKLNEVKEFVKELRGLSQEELAKRENELKKELFELRFQAAAGQLEQTARLKEVKKQIARIKTVQSEVK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: YO316_YEAST
Sequence: MLVPMHNSPTAANGRLSLTVASSGLRKGKKNRVYTIHSYIRSPVSSSEFSFSVRRQYKLTIRIKQKTHL
What are the official names of this protein?
Uncharacterized protein YOR316C-A.
Protein: TRPA_CHRSD
Sequence: MNRIDKRFAALKSQQRRALIPYITAGDPAPQHTVGFMHACVEAGADVLELGVPFSDPMADGPVIQKACERALAKGTRLTDVLDMVATFRATDAETPVVLMGYLNPVERMGYEHFARRAREAGVDGVLMVDMPPEEMAEVAPLFSEHGLQSIFLLAPTTSPSRAATICRHGEGYLYYVSLKGVTGAASLDVDAVERQLAPLREMTDLPLCVGFGIRDGDTAAAVGRVADGVIVGSALVSRIAENAETPEAIPAALKAVLGDMRDALDRSDGR
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: GATD_SULIK
Sequence: MQENYKAKAYDILKNLNIEEGDLIEIKKGDLRIRGILLPSYSKDERIFVIKLDNGYNIGISIDNISEIKLITKNSSKAQESERKEVSRNGAKSEIKIISTGGTIVSKVEYETGAVRPALTTEEIVQFLPEINEIAKVDAEVLFSILSENMKPEYWVKIAESVKKAFDEGNTGVVIAHGTDTMAYTASALAFSLRSLQGPVVLVGSQRSSDRPSSDSAINLLSAVTTAKYAPFGEVVVNMHADSSDTYALVHRGVKVRKMHSSRRDAFQSVNDKPLAKVLWKERKLVMLDKSYMSKKGETTLDAKFDNRAFLLYYYPGLDRDFLEHILTNTKIRGLIIAGTGLGHTSSDYVELFRKATKDGIFIGMTTQCLFGRVNMNVYTTGRQLLDAGVTPLEDMLPEVALVKLMWVLAHEQDLEKIRSLMISNLVGEINPRHTLDLFPRWSYE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit D, Glu-ADT subunit D.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family. GatD subfamily.
Protein: VIRB3_RHIRD
Sequence: MNDRLEEATLYLAATRPALFLGVPLTLAGLFMMFAGFVIVIVQNPLYEVVLAPLWFGARLIVERDYNAASVVLLFLRTAGRSIDSAVWGGATVSPNPIRVPPRGRGMV
What is the function of this protein?
VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
What are the official names of this protein?
Protein virB3.
What is the protein family that this protein belongs to?
Belongs to the virB3 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FLA2_ARATH
Sequence: MAYLRRAATALVLIFQLHLFLSLSNAHNITRILAKDPDFSTFNHYLSATHLADEINRRQTITVLAVDNSAMSSILSNGYSLYQIRNILSLHVLVDYFGTKKLHQITDGSTSTASMFQSTGSATGTSGYINITDIKGGKVAFGVQDDDSKLTAHYVKSVFEKPYNISVLHISQVLTSPEAEAPTASPSDLILTTILEKQGCKAFSDILKSTGADKTFQDTVDGGLTVFCPSDSAVGKFMPKFKSLSPANKTALVLYHGMPVYQSLQMLRSGNGAVNTLATEGNNKFDFTVQNDGEDVTLETDVVTAKVMGTLKDQEPLIVYKIDKVLLPREIYKAVKTSAPAPKSSKKKPKNAEADADGPSADAPSDDDVEVADDKNGAVSAMITRTSNVVTAIVGLCFGVWLM
What is the function of this protein?
May be a cell surface adhesion protein.
What are the official names of this protein?
Fasciclin-like arabinogalactan protein 2.
What is the protein family that this protein belongs to?
Belongs to the fasciclin-like AGP family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: DNAK_STRP4
Sequence: MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAEDYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVXRIVNEPTAAALAYGLDKTDKEEKXXVFDLGGGTFDVSILELGDGVFDVLSTAGDNKLGGDDFDQKIIDHLVAEFKKENGIDLSTDKMAMQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEMTLTRAKFDDLTRDLVERTKVPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAEADKKRKEEVDLRNEVDQAIFATEKTIKETEGKGFDAERDAAQAALDDLKKAQEDNNLDDMKAKLEALNEKAQGLAVKLYEQAAAAQQAQEGAEGAQATGNAGDDVVDGEFTEK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: WDR70_XENLA
Sequence: MDENEDSSIAATMGFSGFGKKARTFDLEAMFEQTRRTAVERSKQTLEAREKEEQLSNKSPVIKGAPSSSGQKKTKASGSSSGSEDSSDDELIGPPLPPNVTGDHGDELIGPPLPPGYKDSDDEDDEEHEDDDNPVKDIPDSHEITLQHGTKTVSALGLDPSGARLVTGGYDYDVRFWDFAGMDASLQAFRSLQPCECHQIKSLQYSNTGDVILVVAGNSQAKVLDRDGFPVMECVKGDQYIVDMANTKGHTAMLNGGCWHPKIKEEFMTCSNDGTVRTWDVSNEKKHKGIFKPRSVQGKPVIPTCCTYSRDGKFIAAGCQDGSIQIWDRNMSVHTKFHCRQAHTPGTDTSCVTFSYGGNVLATRGGDDTLKTWDIRKFKNPLNVASGLENFFPMTDCCFSPDDKLLITGTSVKRGIGDGKLLFFDVVTFQKIYEIQVTEASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNRSQRGAKLCVVKTQRKERQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPVKSHKPEPPVAGPGRGGRVGTHGGTLSSFIVKNIALDKTDDSNAREAILRHAKDAEQNPYWVAPAYSKTQPNTVFAEVDSDEEEPDNEPEWKKRKI
What are the official names of this protein?
WD repeat-containing protein 70.
What is the protein family that this protein belongs to?
Belongs to the WD repeat GAD-1 family.
Protein: CCD86_BOVIN
Sequence: MDTPLRRSRRLEGLKPESPENPTSVLRVRRVLVEFESNPKETGEPRSPPGLGSPSRQPETSPGSPSLPNGPALGSPRKQPELDSGSPEGHRDPGLNFPQNQPESSPESHLLQPKPSEESPKFSQNQGEADSELPKSKEEPTPGCPRHQLQQDSGSLEPFPGQKAPGPEPSKPLQELTPRSPGSPRDQHEPSKPPAAGEPAREGPAPKKREGSSAQAPASKKPKEEIPVIPKGKPKSGRVWKDRSKKRFSQMVQDKPLRTSWQRKMKDRQERKLAKDFARHLEEEKERRRQEKKKRRAENLRRRLENERKAEIVQVIRNPAKLKRAKKKQLRSIEKRDTLAQLQKQPPQRPATKV
What are the official names of this protein?
Coiled-coil domain-containing protein 86.
What are the subcellular locations of this protein?
Nucleus.
Protein: GEMI2_XENLA
Sequence: MPRLLPVEACDLPEDYDPSVPPRTPQEYLRRVQIEAARCPDVVIAQIDPKKLRKKQTVSISLSGCQPAPDGYSPSLRWQQQQVAQFSAVRQSLHKHRGHWRSQPLDSNVTMPSTEDEESWKKFCLGERLYSDLAAALNSESQHPGIDYIKVGFPPLLSIVSRMSQATVTSVLEYLVNWFEERNFTPELGRWLYALLACLEKPLLPEAHSLIRQLARRCSQIRAGVEHKEDDRVSPLNLFICLVGRYFEQRDLADCGDPS
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:9323130).  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity).  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity).  Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity).  Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity).
What are the official names of this protein?
Gem-associated protein 2, Gemin-2, Component of gems 2, Survival of motor neuron protein-interacting protein 1, SMN-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the gemin-2 family.
What are the subcellular locations of this protein?
Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.
Protein: SAER_STAAN
Sequence: MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGYDIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMKKYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEKVWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
What is the function of this protein?
Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion.  Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes (By similarity).
What are the official names of this protein?
Response regulator SaeR, Staphylococcus exoprotein expression protein R.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADCY7_MOUSE
Sequence: MPAKGRYFLNEGDEGPDQAALYEKYRLTSLHGPLLLLLLLVAAATCIALISIAFSHEDLRRHQVVLGTAFLMLTLFVALYVLVYVECLVQRWLRALALLTWACLMVLGSVLMWDSLENEAHAWEQVPFFLFVVFVVYALLPLSRRAAIVAGVTSTVSHLLVFGAVTRAFQTSMSSTQLGLQLLANAVILLGGNFTGAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHYMPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLKEMNIRTYLVIDPRSQQPPPPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESVSSSETPISNGRRQKAIPLRRHRAPDRSASPKGRLEDDCDDEMLSAIEGLSSTRPCCSKSDDFHTFGPIFLEKGFEREYRLVPIPRARYDFACASLVFVCILLVHLLVMPRMATLGVSFGLVACLLGLVLSFCFATEFSRCFPSRSTLQAISESVETQPLVRLVLVVLTVGSLLTVAIINMPLTLNPGPEQPGDNKTSPLAAQNRVGTPCELLPYYTCSCILGFIACSVFLRMSLELKAMLLTVALVAYLLLFNLSPCWHVSGNSTETNGTQRTRLLLSDAQSMPSHTLAPGARETAPSPSYLERDLKIMVNFYLILFYATLILLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSAPSGHENQDLERKHVHIGVLVEFSMALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN
What is the function of this protein?
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable).  Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:18541530).  Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (PubMed:23178822).  Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (By similarity).  Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production.  However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (PubMed:20505140).
What are the official names of this protein?
Adenylate cyclase type 7, ATP pyrophosphate-lyase 7, Adenylate cyclase type VII, Adenylyl cyclase 7.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.