PharMolix/UniProtQA huggingface dataset:
Protein: CRSH3_ORYSJ
Sequence: MANAGVNETVAVAVAIDAPGVGHDHGAAGEVRRPSTRRLAPAGSGGRLMAELLGVFNGLTERMGEDVATSSSSRLLFRALKLALPALRDGGGDGGGGQSVSRALVVAASLADLQMDAEVISAGMVRGALDTGALAMADVEAQLGASAAGLVEESLKVKRAPSEVDVADEEAASALRKRCLSSYDIRAVILELAVKLDAMKHLDVLPKHQQRTTSLEVLKVFALLAHAVGAGELSLELEDLSFQRLYPQAYAHIDQWLSSQEDDCKRVIAASKEELLRALTADDELRCTVTGVDVMGRYKSRFSTMKKLVKDGRRPEDVNDILGMRVILDPRPGGGGGGDGDGGDRACLRTHEVIKAMWKDVPARTKDYITRPKGNGYRSLHVAVDMSEPGPEGKKRPLMEIQVRTREMDMAAVGGQASHALYKGGLTDPEEAKRLKAIMLAAAEVAAQHLRDEPAGDGGQTTAAASAATAGNVERAFQLLDKNGDGRISMEELTEIMEDLGAGGHDAEELMRLLDANSDGSLSSDEFALFQKRVKLKTKLENKDDEYKEILKQKLQKVDDTGLIHVYRKNLSDKLVLV
What is the function of this protein?
Possesses calcium-dependent ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase activity in vitro and is able to functionally complement E. coli relA mutants.  May be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses.
What are the official names of this protein?
GTP diphosphokinase CRSH3, chloroplastic, Calcium-activated RelA/Spot homolog 3, OsCRSH3, ppGpp synthetase CRSH3.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CYB_SPEMA
Sequence: MTNTRKTHPLIKIINHSFIDLPAPSNISAWWNFGSLLGLCLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYTYFETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDXATLTRFFAFHFILPFIIVALVMVHLLFLHETGSNNPSGLISDSDKIPFHPYYTIKDILGVLLLVLTLMALVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILMLFPLLHLSKQRSMMFRPLSQCVFWILVADLFTLTWIGGQPVEHPFIIIGQLASILYFAIILLILPTVSMIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ILVC_SALHS
Sequence: MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDIAYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSDVVRSVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVAEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMTPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQFEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGSAIPEGAVDNAQLRDVNDAIRSHAIEQVGKKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ACCD_CLOPE
Sequence: MIKNLLNKRKYITVSSVELNDTELSEDEKPNIPSGMWSKCEKCAKILYTEDLRENFNVCPNCGHHFKLGAYERIKYLTDENTFVEFDKKMIGRNPLDFNGYEEKIKGYQKKSHVIEGVVTGEAYIAQRKVVLCVMDSNFMMGSMGTAVGEKITRAIEYATKNRLPLIIFTCSGGARMQEGIYSLMQMAKVSGAIYRHGRENLLYITVLTNPTTGGVTASFAMEGDIILSEPGCLVGFAGRRVIEGTINEKLPDDFQTAEFLLEKGFIDKIVQRKDLKQVITSLLRMHEVDYE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_STRMK
Sequence: MKIVEVRHPLVQHKIGLMRNAALSTKDFRELANELGTLLAYEATADLDTEPHTLAGWAGPVTVQRIAGAKITVVPILRAGLGMLSGVLSLIPAARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLVAAPEGIEAVKAVHPDVEIYTAAIDAQLNDKGYILPGLGDAGDRIFGTRVG
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: NU6M_ASCSU
Sequence: MLGSFFFLAIISCVMSYINVDPMKSSFFLIFSLLMVMPLISFFLHVWFSYFICLLFLSGIFVILVYFSSLSKIGYVVTPFYFVGGVLSVFFFYPFFYSVTDVVAVNNFYFSVYWMLLVWVIFVLIFFMNFTSYFLNFSGALRKV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: IF1_BUCAP
Sequence: MTKEDNIEMQGIVIDTLPNTMFRVELENKHVITAHISGKMRKNYIRILTGDKVTIELTPYDLTKGRIIFRSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCNP_HUMAN
Sequence: MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN
What is the function of this protein?
May be involved in cell cycle regulation.
What are the official names of this protein?
PEST proteolytic signal-containing nuclear protein, PCNP, PEST-containing nuclear protein.
Protein: IOLC_LACCA
Sequence: MPQKFDLIAIGRAAVDLNAVEYNRPLEDTKTFAKFVGGSPANIAIGSAKLGQKVGFIGKVSDDQLGHYVTQYMASVGIDTSNMVKDDTGHKIGLTFTEIISPEESDILMYRNEAADLYLNAHEVSRAYLAQTKMLVISGTGLAQSPSREAILKALLIAKELGVEVIFELDYRPYTWQNAEETSLYYQLVAQKADVIIGTRDEFDVLENHQGRTDQETIATLFQYDANLIVIKSGIQGSNAYTKAGETYHFGVFKTKVLKSFGAGDSFAAGFLYAYQHQLGLETALKYGSAAASIVISQLSSSEAMPNLDQLTAFIEKAEAQEVHQS
What is the function of this protein?
Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).
What are the official names of this protein?
5-dehydro-2-deoxygluconokinase, 2-deoxy-5-keto-D-gluconate kinase, DKG kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: URE2_TRIEI
Sequence: MIPGEIITQIGEIELNSGRSTIQVIVANTGDRPIQIGSHFHFYEVNSALEFEREPTKGMRLNIPAGTAVRFEPGDEKEVELVAIAGSREIYGFNSLVNQKLE
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSTB_LACDA
Sequence: MMEDKITIEKLNLYYSDFHALHDINMHIQKNEITAFIGPSGCGKSTLLRSLNRMNDLVEGCRIDGSIKLDGTDIYNGDLDVTVLRQRVGMVFQRPNPFPMSVYDNVAYGPRIHGITDKKELDEIVETSLKQAAIWDDLKDRLKKSALGLSGGQQQRLCIARALAVKPEVLLMDEPTSALDPISTSKIEELALELKKNYTIVIVTHNMQQAVRISDKTGFFLLGDLVEFGETDQLFSMPKDERTEKYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: BABA2_HUMAN
Sequence: MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748).  In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748).  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665).  Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113).  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665).  The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985).  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).  May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins.  May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.  May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831).
What are the official names of this protein?
BRISC and BRCA1-A complex member 2, BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, Brain and reproductive organ-expressed protein.
What is the protein family that this protein belongs to?
Belongs to the BABAM2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: DAPA_SHEB8
Sequence: MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMSEHVTVVSQTVKFAAGRVPVIGGNGANATSEAVELTKSLSKVGVAAMLGVTPYYNKPTPKGLIAHYKAVAASTDIPQILYNVPGRTAVDMLPETVAELVSVSNIIGVKEATGDLSRVKRLRELCGDDFLLYSGDDATAREFLLLGGNGVISVANNIVPQAFKAMCDAALAGNAELALSIDTPLRGLYSTLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLIEAMTRAQIEVK
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PABN3_ARATH
Sequence: MEEEEHEVYGGEIPEVGDTDVPDPDIDMSAADEDAVTELAEMKRRLKEMEEEAAALREMQAKVEKEMGATQDPASMAANQEGKEEVDARSVYVGNVDYACTPEEVQLHFQTCGTVNRVTILMDKFGQPKGFAYVEFVEVEAVQEALQLNESELHGRQLKVSPKRTNVPGMKQYHPGRFNPSMGYRFRRPFVPPYFYSPYGYGKAPRFRRPMRYMPYQ
What is the function of this protein?
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product.  Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length.  Increases the affinity of poly(A) polymerase for RNA.  Binds to poly(A) and to poly(G) with high affinity.  May protect the poly(A) tail from degradation.
What are the official names of this protein?
Polyadenylate-binding protein 3, AtPabN2, AtPabN3, Poly(A)-binding protein 3, Nuclear poly(A)-binding protein 3, Poly(A)-binding protein III, PABIII.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus.
Protein: RS3_ECOSE
Sequence: MGQKVHPNGIRLGIVKPWNSTWFANTKEFADNLDSDFKVRQYLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSITSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEKPAAQPKKQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: GH_EBVA8
Sequence: MQLLCVFCLVLLWEVGAASLSEVKLHLDIEGHASHYTIPWTELMAKVPGLSPEALWREANVTEDLASMLNRYKLIYKTSGTLGIALAEPVDIPAVSEGSMQVDASKVHPGVISGLNSPACMLSAPLEKQLFYYIGTMLPNTRPHSYVFYQLRCHLSYVALSINGDKFQYTGAMTSKFLMGTYKRVTEKGDEHVLSLIFGKTKDLPDLRGPFSYPSLTSAQSGDYSLVIVTTFVHYANFHNYFVPNLKDMFSRAVTMTAASYARYVLQKLVLLEMKGGCREPELDTETLTTMFEVSVAFFKVGHAVGETGNGCVDLRWLAKSFFELTVLKDIIGICYGATVKGMQSYGLERLAAVLMATVKMEELGHLTTEKQEYALRLATVGYPKAGVYSGLIGGATSVLLSAYNRHPLFQPLHTVMRETLFIGSHVVLRELRLNVTTQGPNLALYQLLSTALCSALEIGEVLRGLALGTESGLFSPCYLSLRFDLTRDKLLSMAPQEAMLDQAAVSNAVDGFLGRLSLEREDRDAWHLPAYKCVDRLDKVLMIIPLINVTFIISSDREVRGSALYEASTTYLSSSLFLSPVIMNKCSQGAVAGEPRQIPKIQNFTRTQKSCIFCGFALLSYDEKEGLETTTYITSQEVQNSILSSNYFDFDNLHVHYLLLTTNGTVMEIAGLYEERAHVVLAIILYFIAFALGIFLVHKIVMFFL
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL.  May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.  The heterodimer gH/gL targets also host EPHA2 to promote viral entry.
What are the official names of this protein?
Envelope glycoprotein H, gH.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein H family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: TRMA_ALTMD
Sequence: MSADEQQRYQAQLDEKVDRLSALLSPFNAPKTSVYPSQPTHYRMRAEFRVWHEGDDLFHIMFDQETKEKYRVDSFPPACKTINDAMEKLLNEIRPNEILRKKLFQIDYLSALSGELVISLLYHRQLDDEWEAAAKSLKSTLETHFPKVNIIGRARKQKRIIDNDFVIERLPVKGNEFVFKHIENSFTQPNAEVNCKMIEWALDCVKPLSGDLLEMYCGAGNFSLPLALHFDNVVGTEIAKPSVQAAQFNIEQNRLHNVKIVRLAAEEFTQAMKGKRTFSRLEGIDLSEYNFTTVLVDPPRAGLDEDSLRMIQDYDNIVYISCNPETLAQNLELLSETHDVAQSALFDQFPFTHHIEAGVLLTRKG
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: ARP19_RAT
Sequence: MSAEVPEAASAEEQKEMEDKVTSPEKAEEAKLKARYPHLGQKPGGSDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQLPAAAPDKTEVTGDHIPTPQDLPQRKPSLVASKLAG
What is the function of this protein?
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.  When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).  May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA.
What are the official names of this protein?
cAMP-regulated phosphoprotein 19, ARPP-19.
What is the protein family that this protein belongs to?
Belongs to the endosulfine family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_BUCA5
Sequence: MARIAGINIPENKHTLIALTAIYGIGKKRSKFICSIANIPEHSKIVDLNEEQIDLLRTHVAKYVIEGDLRRERTLNIKRLIDLSCYRGLRHRRSLPVHGQRTKTNARTCKGPRKPIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: SIF1_DROME
Sequence: MGNKLSCSCAPLMRKAYRYEDSPWQSSRRRDGHLLSSFRLWAEVFHVSASGAGTVKWQQVSEDLVPVNITCIQDSPECIFHITAYNSQVDKILDVRLVQPGTRIGQASECFVYWKDPMTNDTWGLNFTSPIDAKQFRECCSPSFKFSRKASSSYSLKLDPPGKGKVKAKRKPLSTPASPSRVRQEPQCTCMSAEQYARLRTDPRVRGSSTLPRNVGSHRITDVDGQQQVGSGKVVSAVSSTSLYDNVASGGPGTNQGADTLPRQMKGGQQDRQDVANSGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQAGGGLHQSVGTCTSSSKGTGTRNKDFGDDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMNVDTSTLKRMLKPMPSTESPVTSPEMGRRRYNYYNANAAQTLGHPPHMHQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSSRFSGSRSSHEIGRGYPPRNLYLELERERSCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQQGPPQRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLANAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGSPVWKPRDMINLGTDPQSTTRKDDVKN
What is the function of this protein?
Regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating Rho-like GTPases.  Is likely a factor in the cascade of Rac1 or Cdc42 in the neurons (PubMed:8999801).  May play a role in maintaining proper septate junction functions.  Required for eye development and most likely affects corneal lens-formation (PubMed:30290152).
What are the official names of this protein?
Protein still life, isoform SIF type 1.
What are the subcellular locations of this protein?
Synapse. Note=Localizes to the submembranous region of synaptic terminals.
Protein: KITH_LATSS
Sequence: MAQLFFRYGAMNSGKSIEILKVAHNYEEQNKSVIILTSGIDNRDGVGIVSSRIGLKREATPIFSDTNIYELVEATNPDAACVLIDESQFLERHHVIEAAKVVDDLNIPVMAFGLKNDFKNELFEGSKYLLLFANKIEEMKTICWFCRKKAIMNLRMNNGLPVYTGEQIQIGGNEAYYPVCRKHYFNPPIQEEIEKEG
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR6Y1_HUMAN
Sequence: MTTIILEVDNHTVTTRFILLGFPTRPAFQLLFFSIFLATYLLTLLENLLIILAIHSDGQLHKPMYFFLSHLSFLEMWYVTVISPKMLVDFLSHDKSISFNGCMTQLYFFVTFVCTEYILLAIMAFDRYVAICNPLRYPVIMTNQLCGTLAGGCWFCGLMTAMIKMVFIAQLHYCGMPQINHYFCDISPLLNVSCEDASQAEMVDFFLALMVIAIPLCVVVASYAAILATILRIPSAQGRQKAFSTCASHLTVVILFYSMTLFTYARPKLMYAYNSNKVVSVLYTVIVPLLNPIIYCLRNHEVKAALRKTIHCRGSGPQGNGAFSS
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 6Y1, Olfactory receptor 6Y2, Olfactory receptor OR1-11.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: WNT1_XENLA
Sequence: MRILTFLLGLKTLWVLAFSSLSNTIAVNNSGKWWGIVNVASAGNVLPGSDARPVPLVLDPSLQLLSRQKRLIRQNPGILQSITRGLHSAIRECKWHFRNRRWNCPTGTGNQVFGKIINRGCRETAFVFAITSAGVTHSVARSCSEGSIESCSCDYRRRGPGGPDWHWGGCSDNIEFGRFIGREFVDSSERGRDLKYLVNLHNNQAGRLTVLTEMRQECKCHGMSGSCSLRTCWMRLPPFRSVGDALKDRFDGASKVTYSNNGSNRWGSRSDPPHLEPENPTHALPSSQDLVYFEKSPNFCSPSEKNGTPGTTGRICNSTSLGLDGCELLCCGRGYRSLAEKVTERCHCTFNWCCHVTCLNCTSSQIVHECL
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors (Probable).  Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity).  Plays an important role in patterning during embryonic development (PubMed:2673541).  Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity).  Has a role in osteoblast function, bone development and bone homeostasis (By similarity).
What are the official names of this protein?
Protein Wnt-1, XWnt-1, XInt-1.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.