PharMolix/UniProtQA huggingface dataset:
Protein: PHS_BRUA4
Sequence: MARNRLTENELNEALTELDGWQKVDGREAIAKSFKFKDFNAAFGFMTRAALHAEKLDHHPEWFNVYNRVDVTLATHSENGITELDIKLARKMNAIA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: CP11A_HYPAM
Sequence: SFRLSLSASTYAQRGSFTTPEHDFTLFPHRNHSVTSESRIPSEQTLKSLTDIPGNWRKNWLNVYYFWRSNGLNNAHQWMLDNFNKYGPIYREKIAYYESINIINPADAVIMNKSEGPFPKRIEMAPWVAYRDLRKENYGVQLLNGENWKRTRLILNNSIFAQSSIQRLVPLFNEVVLDFVSMVHKEVEKSRSDYWKTDLTNDLFKLALEVICYILYGERLDLLQRKYNKAPQKFIDSIATMFHSTPIMLYVPPSLLKSINSKIWQQHVGSWDNIFEHADTYLKKAYRQFQQGSKNEHAFPGVLTELLLQGALPFEDIRASIIDVMSGAIDTTSTTVHWMMYELAKHPHIQKNVRSEIMEAHQKTEGDPVKMLKSVPLLKCVVKETLRLYPVAISIQRYLNEDTVLQNYHIPAGTLVQLGLYAMGRNPKIFKNPEQYNPERWLKGEDTHFRHLGFGFGPRQCIGRRIAETQMVLLMIHMLQNFKIETDPMTEVKSKFSLILIPDKPINLKFTPIK
What is the function of this protein?
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones.
What are the official names of this protein?
Cholesterol side-chain cleavage enzyme, mitochondrial, CYPXIA1, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450(scc).
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane.
Protein: ASIP_PAPAN
Sequence: MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: MURG_RUEST
Sequence: MTQKLLLMAAGGTGGHMFPAQALAEAMLRKGWRVKLSTDPRGARYTGGFPHMTEITEVSSATFARGGLLAKAMVAPRIAAGVASMAMQMRRDRPDVVIGFGGYPSIPALGAATLLGLPRMIHEQNGVLGKVNQKFATRVAEVACGVWPTDLPAGAEGIHVGNPVRAAVLERQGAPYIPPGDYPMSLLVMGGSQGARILSDVVPGAIAALPETLRRHLRVSHQAREEDMARVAQFYADAGIDAEVQTFFADVPSRISEAQLVISRSGASSIADISVIGRPSILIPLATAAGDHQTANTRGLVEAGGAIRIPESALDTTSLAEQIAAVLTNAEGATQMAHAALSTGIPDATERLVARVEHLSEEAAP
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GYRB_CLOAB
Sequence: MSEKNEIYDESQIQVLEGLEAVRKRPGMYIGSTGTRGLHHLVYEIVDNSIDEALAGYCSHIKVFIHKDNSVTVSDDGRGMPIGIHHKMKKPTVEVIMTILHAGGKFGGGAYRVSGGLHGVGASVVNALSETCEVEVKTEGHIWKQTYHRGKVASPFEKIGDSDEHGTKIYFKPDPEIFEDTEYDYDTLSQRLRELAFLNKGIKIELTDERHDKNEIFHYEGGLKSFVSYLNRNKEVVFKEPIYVEGSIDSNYSVEIALQYNDGYNENIFSFANNIHTIEGGTHLAGFKTALTRVINDYAKKFGYLKENDKNLSGEDIREGLTAVVSVKLTEPQFEGQTKTKLGNTEVRGIVDSIISERVSTYLEENPQIGKLVIDKALVASRAREAAKKAREITRRKSVLESTSLPGKLADCSSKDAEECEIYIVEGDSAGGSAKQGRNRRFQAILPLRGKIMNVEKQRIDKILNSEEIKAMATAFGGGIGKDFDVSKLRYHKIIIMTDADVDGAHIRTLILTFFYRYMTELISEGHVFIAQPPLYKVTKTRKEYYAYSDKELEDVLQDVGGKDKNTDIQRYKGLGEMNPEQLWETTMNPEQRTLIKVNIEDAMAADEIFTILMGDKVDPRRKFIEENATKVVNLDV
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBIA_PICTO
Sequence: MKINSIIIGAPSSSSGKTTISIGIMRALSRRLRVQPFKVGPDYIDPGYHNIATGRFSSNLDTWMSSREKMKEIFIKRSTGSDISIIEGVMGLYDGKQPDKDTGSTAEVARTLKSPVIIVIDISAMARTAAAIILGLIKMDKRLRISGVILNNAGSDYHCSIVRTAIEKYTGIPVIGCVKRSDDLKIDDRYLGLKTAMEDDNSGKIDKIADIIERSVDLDLLIKISKESGDISFKSGLFSKKNVNRVRIAIAYDAAFNFYYYDNIEMLKMYGAEIVYFSPLNDYKLPEADGLYIGGGFPELFAERLSDNYSIKKDIMEFFNSGRPVFAECGGYMYLSRGIKINGKYYEMASIINGESYMDSLILGYRNIRAESNNILMMGGWHVKGHEFHYSRLNVNANAYKTERGPDGISTKNLLAGYMHLYFPSNPRIPERFVRSCYNV
What is the function of this protein?
Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
What are the official names of this protein?
Cobyrinate a,c-diamide synthase, Cobyrinic acid a,c-diamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CbiA family.
Protein: FTSW_XANOR
Sequence: MAGAARDRAFLDHFGGAGADRPCHVEGALMNDMSRQATRLDAIGGRYDPWLLGAAVTLASLGVVMVASSSIELEASPFYYLTRHLLFLGGGIALAFWAMRTELKTIEQHNQMLLLACFVLLVVVFVPGLGSTVNGAKRWINLGVSRFQVVESVKVFYIIWLASYLVRFRDEVNATWQAMLKPVFVVGLLVGLLLLQPDFGSSMLLLSVTACMLVLGGAPIGRIILPILLLLPALVALVIFEPYRMRRVTSFMDPWVDQLGSGYQLSNALMAIGRGQWTGVGLGASVQKLNYLPESHTDFIFSVIAEELGFVGVCGVIGLYALLVGRAFWLGMRCVEMKRHFSGYIAFGIGLWIAMQSFVSIGVNLGILPTKGLTLPLISSGGSSVLMTCLAMGVLLRVSYEADRAERLRSKLSPQGAAISPGEPAEPVVDAVPPAYAPARKPQRDTAAAPAPAAAPVAAHVAPASAILRGTSRMQPRVEPTFGRIA
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell division.
What are the official names of this protein?
Probable peptidoglycan glycosyltransferase FtsW, PGT, Cell division protein FtsW, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. FtsW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Protein: ANPRA_HUMAN
Sequence: MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
What is the function of this protein?
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis.  Has guanylate cyclase activity upon binding of the ligand.
What are the official names of this protein?
Atrial natriuretic peptide receptor 1, Atrial natriuretic peptide receptor type A, ANP-A, ANPR-A, NPR-A, Guanylate cyclase A, GC-A.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: LEU3_THET2
Sequence: MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGLANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLEAPPPDLGGSAGTEAFTATVLRHLA
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity).
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_PARXL
Sequence: MNLNATLFAQMVVFLILAWFTMKFVWPPLINALDERSKKIADGLSAAEKGKAELEAAHKRVDQELAQARNDGQQRVADAEKRAVAVADEIKAQAQAEAARIIAQAKADAEQQVVKARETLRGEVAALAVKGAEQILKREVDQAAHADLLNQLKAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: FMT_PERMH
Sequence: MRVVFWGTPDFAVESLKALIESKHQVVAVVTQPDKPKGRGKKVQPPPVKVLAEKYSIPVFQPEKVKGNKELYQKLKELEPDIFVVVAYGKILPEEIINLPKYKTVNVHASLLPEYRGAAPIHRAIMEGKEKTGVCIMEIVKELDAGDIYQCVEIPITDQDDIVSLHDKLAKEGAKLLLDTLDKIEKGEIKKVPQDHERATYAKPIEKEEGRIDWKRSAREIFNQVRALKVWPKAFSNFRDTQIKILECEIIDERSEGEPGEIVKIMKDEGFVVQTGKGKLLIKKVQFPNSKPISAADAVRGYRIKEGEKLF
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: TK1B_HADVE
Sequence: TICTGADRPCAACCPCCPGTSCQGPEPNGVSYCRND
What is the function of this protein?
This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type).
What are the official names of this protein?
Lambda-hexatoxin-Hv1b, Lambda-HXTX-Hv1b, Janus-atracotoxin-Hv1b, Janus-AcTx-Hv1b, Kappa-atracotoxin-Hv1b, Kappa-AcTx-Hv1b, Kappa-hexatoxin-Hv1b, Kappa-HXTX-Hv1b.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 11 (kappa toxin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRP46_CRYNJ
Sequence: MSTSLETPSGASAGPSIVASGLPPLADLVRAGSKRTRVVYGAETSAVEDDGLARANKIKLATKLAIEYKDVQTLPPILQAQQTGPAGPKRPTQPSIAASATAGPNVKLIGGPEAEKASSSTPQAVAEPRSLVKFRHQEGFAAEGGQATSRLSQALMRKKEAREVKPEYHPEWKLTRVISGHMGWVRAVAMDPGNQWFATGAGDRVIKIWDLASGELKLSLTGHISTIRGLAVSDRHPYLFSCAEDKMVKCWDLETNKVIRHYHGHFSGVYSLSVHPTLDVLVTGGRDASVRVWDMRTRANIFTLTGHTSTVGDVKTQDSDPQIISGSMDSTVRLWDLAAGKCMNTLTHHKKSVRALAIHPTEYSFASASSGGNNIKKWKCPEGIFVNNFVGHEAIINTLSINSENVLFSGADNGTLTLWDYKTGLPFQHLKDIPQPGSLDAEAGVFCSTFDKTGTRLITGGADKTIKVYSEQA
What is the function of this protein?
Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
What are the official names of this protein?
Pre-mRNA-splicing factor PRP46, Pre-mRNA-processing protein 46.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PRL1/PRL2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y140_NPVAC
Sequence: METLSIEIRLYMRRRAWSRRHFAHGTRAVEGTGYIKPVCPTRKSVSIVLRRTRSLARRIV
What are the official names of this protein?
Uncharacterized 7.1 kDa protein in ME53-IE0 intergenic region.
Protein: COX5B_SOLTU
Sequence: TVSENVVKKVEDVMPIATGHEREXLXAQ
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 5B, mitochondrial, Cytochrome c oxidase polypeptide Vb.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5B family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: TPM_DERPT
Sequence: MEAIKNKMQAMKLEKDNAIDRAEIAEQKARDANLRAEKSEEEVRALQKKIQQIENELDQVQEQLSAANTKLEEKEKALQTAEGDVAALNRRIQLIEEDLERSEERLKIATAKLEEASQSADESERMRKMLEHRSITDEERMEGLENQLKEARMMAEDADRKYDEVARKLAMVEADLERAEERAETGESKIVELEEELRVVGNNLKSLEVSEEKAQQREEAHEQQIRIMTTKLKEAEARAEFAERSVQKLQKEVGRLEDELVHEKEKYKSISDELDQTFAELTGY
What is the function of this protein?
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
What are the official names of this protein?
Tropomyosin.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
Protein: ITR3_LUFAE
Sequence: RICPRILMECSSDSDCLAECICLENGFCG
What is the function of this protein?
Inhibits trypsin.
What are the official names of this protein?
Trypsin inhibitor 3, LCTI-III, Trypsin inhibitor III.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I7 (squash-type serine protease inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PTGA_BACAN
Sequence: MFKKLFGLGSKTNEETIVAPLTGAVKNIEEVPDPVFAGRMMGDGVAIDPTEGVVVSPVDGEIVQLFHTKHAIGIKAKNGTEILIHVGLETVKMEGEGFEAHVSEGQAVKAGDKLISFDLELIREKAKSTITPIVITNTDAAESIKTTVGVTATKGSTEVMKVTMK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II complex composed of PtsG and Crr is involved in glucose transport.
What are the official names of this protein?
PTS system glucose-specific EIIA component, EIIA-Glc, EIII-Glc, Glucose-specific phosphotransferase enzyme IIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLP_TRYCR
Sequence: NSPKGLEATREKVWQVVRSYFRPEFLNRLDDIVLFRRLGFGELHEIIDLIVAEVNGRLRSQDILLEVTDEAKNFVLENAFDAEMGARPLRRWVEKYITTEVSRMILAQQLPPNSTVRVLVNGSQGKLAFSVKRSFVSE
What are the official names of this protein?
Heat shock protein 100, Protein CLP.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
Protein: SRRT_CAEBR
Sequence: MDSDDDGDRRRDKFARERRDDDSYRRSGGGGGGYSRYDNKRPAGRREDYQVKRSRGDEGDDGFDPVRGDRNGNGAEPSSENSIYSGPLLPFKRFLTNQEDDISEEDAIKKYNEYKNEHRKFQLDRFFRAHKDEEWFRLKYKPEEAKKVKEVQLENVQKRLQIFNELKEQGQFDKFTLDFEDAEAILRMLDSVVVKLENGSEDDLKAVLAQKLDDESLADVKKENKDAAEKVEDQVKDEVKEEPNEEQEEGAIDDETDKASNKVNIHKTCSVFLRNIPPGLTYEELESTCKKYPGFLRLALTDGIAERRFYRRGWATFKRDVNIKEICWGLNAHRLRETDLNAIINRDITRRVRTNNGVAAHKQVALNDLKLAVKLTALYDKKLGLFNAADESESDREKDIRMGVDLVAASTNPLVKEIKSIVPKDTLNDISEEEAELLGVSNGGDSQSDKVRYERDDTILKALDLLIIYLRIVHSIDFYNHGHYAQEDSMPNRCGLIHVRGQPPSGASINTDENGDLIVPQKFINDFISGFNSRIDKGLIEKQYVSEEDMEKMGKKDGEKEVEAFIAINTVELAKDKWLCPLSGKKFKGPEFIRKHLQSKHEDKLEEARAEADFFNNYLADAQRPVDLEPKHMPHMSRDDHRGGGGDRGYGRERDDDRGPGGGRSSFGNGSYDRRPPFPPRHSLGGRGGGGRMFDDAPRRQPVSYRDLDAPDDIP
What is the function of this protein?
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery.  Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity).
What are the official names of this protein?
Serrate RNA effector molecule homolog, Arsenite-resistance protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the ARS2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COBT_SINFN
Sequence: MSASGLPFDDFRELLRNLPGPDAAALVAARERDAQLTKPPGALGRLEEIAFWLAAWTGRPPAVNRPLVAIFAGNHGVTRQGVTPFPSSVTAQMVENFAAGGAAINQICVTHDLGLKVFDLALDYPTGDITEEAALSERDCAATMAFGMEAIAGGTDLLCIGEMGIGNTTIAAAINLGLYGGTAEEWVGPGTGSEGEVLKRKIAAVERAVALHRDHLSDPLELMRRLGGREIAAMAGAILAARMQKVPVIIDGYVATAAAAILKAANPAALDHCLIGHVSGEPGHIRAIEKLGKTPLLALGMRLGEGTGAALAAGIVKAAAACHGGMATFAQAGVSNKD
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RL4_ECO57
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: MUKB_ECODH
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLPLNELKDKLEAMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAIERQQENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAIAALNRAKELCHLPDLTADCAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEQAYQLVVAINGPLARNEAWDVARELLREGVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLADFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQRAPVWLAAQNSLNQLSEQCGEEFTSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGSEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQVTEHLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFGRAARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLADRVDEIRERLDEAQEAARFVQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADDLRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQNVSFGQVNSVRLNVNVRETHAMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDESRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLPGTDEAPSQAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: KDM5_CAEEL
Sequence: MRARRQENSISTPSAPSTSTSPRKKASIGNSRSKNHGSKMEMYDQFYKKFVRPPMAPIYYPTEEEFSDPIEYVAKIRHEAEKFGVVKIVPPANFKPPFAIDKEAFTFRPRTQKLNEVEAIVKEKHTFIDRLINFNRYSGLTFEFPVDRDGNIVDLYRLHRIVQNFGGCEEVNEDEKWRDVAREYLPKEQMARGVPSAFINLIRSHYNLHIEPFNRNLKEKAMKNDDESDDEMEELKHKYQHHHGTMRTEIEVPNDKTTEGGEDECPVSMQSGRRRSKNKKASSSRKTLGTSSKKNSTRGRKNKKKAEGDDDDDEDPMDQVFCVACNEGKDEDLLLLCDIDGCNNGRHTYCCDPVLDEVPEGEWRCPKCIESEDAKIGLDWGFYDADTEYNLNSFTEFANKWKCDYFGVKDVSQVSCDAVERSFWKNVISHENPVSVKYGADLITSRVGSGFPRKEDKHTGPDLKLKQQYASHAWNLNNMPVLRESVLSHFNTGISGMMVPWVYVGMCFSTFCWHTEDHWTYSVNYNHFGERKIWYGVGGEDAEKFEDALKKIAPGLTGRQRDLFHHMTTAANPHLLRSLGVPIHSVHQNAGEFVITFPRAYHAGFNEGLNFAEAVNFAPIDWLSKGRECVESYSNVRRYLVFSHDELLFKMVEAMDKLGISMSLATHEELIRIYEKQKMLRELLARLGVSNRQMQQVMFEKIPDEQRSCRFCKTTLFMCALVCNKHKKMTCVEHHDHLCNSCTTKDYRYQYRFELDQLNNMCDELGKRTVNYNGWKEESDEMLEEEGKPKLERIEEFIDSAKQNKYPQTDQVHKLITIRHTAKSAIEKANQLLFKKVRTRTKTRCQRADTRTDTEGVRSLIEQMQAMDCNLTVIIDKLEKWMEQVEMWRNRAKDAIYREQEYSKEEIEKIIEEGDEYDIKLEEIDELRKVIQMKDWSDRARKVTTWKATPDMEKDIDFEYKLRYASSDILSLIRDSPRNPTDGTSKLVFELQQMLRDANTLEVIANNFCENPALDQLQSIWQSLRETDWFYEKYINMVRYEIIHVAKIKSMIDAAIPVLSEFDLKTQLQKIVNVEITLSKAAEISKAFETSKCLNGSEEHLGILDMISTMNAFTQRIAILFKPNNAYHNLFEILSERDDLTPLAEGQTIPLYFQGGAVHPSDEWHQMKEFESLDQIVHHQSSLREMQMRIFEKVKQANSARGLEACSCLGFNKSDDSESTLTCIMCDSEFHVRCCEWSPFLEKLPEGCFLCVRCLRGQRPVIDDVTTALNGTPSGCLETHLVRNLIQKTRGITQNLMEAANKRKSGESSDDICKIALFDWLSCEILNPNGLPKARELISEFYMEYLQKQSSAALELKNRPVRSKPSVSLFDPKITAKRKRPSVSHKETSKKSRKRQSQASPSEYYEDESEFKSCQARACLKPYGDSVNWVMCEAGCKNWFHVICLGFTLREINDMHEYRCSSCLDHADSPTSSVSTD
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:17320161).  Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20' (PubMed:17320161).  Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4' (PubMed:17320161).  Required for normal longevity of the soma in a germline-dependent manner (PubMed:20555324, PubMed:22212395).  Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258).  Involved in larval development and vulva formation (PubMed:17320161).
What are the official names of this protein?
Lysine-specific demethylase rbr-2, Histone demethylase rbr-2, Jumonji/ARID domain-containing protein rbr-2, [histone H3]-trimethyl-L-lysine(4) demethylase rbr-2.
What is the protein family that this protein belongs to?
Belongs to the JARID1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: APAG_BRADU
Sequence: MYRAVTRQIEVTVEPNFVPEQSSADRSRYFWSYTIVITNSGEETVQLKTRHWIITDATGRQQEVKGEGVVGEQPTLAPGERFEYTSGVPLSTASGFMTGRYQMVSESGERFEIDVPTFSLDSPDNKRVLN
What are the official names of this protein?
Protein ApaG.