PharMolix/UniProtQA huggingface dataset:
Protein: CHED2_SYNAS
Sequence: MNSKAIKPSCEYFLLPGYIFMSPEPYLISTVVGSSVAVALWDADSKLGGMLSFLYPFRESSAESTAIYGNVAITYMVRMFREEGAKKKNLRSQIFGGAESDCCEADQIAHENVKTARSVLKKHGIKVISEDVGGRLGRKIVYNTFQNEALIYKVNTLRNSDWYPYDGQGRQA
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD 2.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: LPXC_CHLAB
Sequence: MLERAQRTLRREVRYSGVGIHFGKSATITLEPAKENTGIVFCRSDLLGEHIPALLPHVCNTGRSTTLSSGDSIIATVEHLMAALRSSNIDNVIVRCDEEEIPIGDGSSHVFMQLIHDAGVCTQNDKVSIARLSQPVYYQAQDTFLAAFPCDELKISYTLHYPQSPTIGTQYRSFVITEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLENAVVFKDDGVISLGQLRFPDEPVRHKILDLIGDLSLVGRPFVAHIVAVGSGHSSNIALGRKILEVLQP
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: BUD8_YEAST
Sequence: MIQSDEDNLDSSETTASTSYSGTSSVSSRLQLRTSLFFENLNGAHGNPDAETEMATVAYETTSRGQGFAVYINNERFSQIMGASTSSSSSSNSSSITQFHDTQDNNIPSNTTVRPTSLRRDNEDTVPLRNVTPSQNAAVRPERAVNSPSSQRLSCALTISTSVLMGEDVEGSPIEQEHSRVVSSLYSSLANRGNDESKNGTPPRPTSIEPNETTEHSFFSYHYDDTLEPDVEEAVRLTKNKTSNVNFISSTGSKGEGETEDEVIDQYEPVNESKFIPHKLKIPEKAGSIKSSTSDDSHSPGAPGTSARKIKIPQSPSLIGNILIPSHNSDSSNESSPKDHIGHNNEEKFSSKSTRKPSTSLEEEGPPIGLPSIPVLRSVSGPSKWTKTPLRLESGNSTKSDPFSRYEGHKTPSPLTKMNKKKNKTLPEHGQPLVLAPIKSQSSESDTGQNSIIEKPARSIRRKQQEKTDNRKEDRHDAENIDLEARMPIQHIDTASIHSFDSGQNGFRDVYSIENIIVILLCCSIVPPLFFIIGCSSRRKLVSDYRLMRLLMNKEHRAALLQGFIWDVDLRWFRMFCLILGAAETVIVMAGIAIGFGVGITRE
What is the function of this protein?
May be involved in positioning the distal bud pole signal.
What are the official names of this protein?
Bud site selection protein 8.
What is the protein family that this protein belongs to?
To yeast BUD9.
Protein: HIS7_BURMA
Sequence: MRVAQVVRNTSETQISVKIDLDGTGRQKLATGVPFLDHMLDQIARHGLVDLDIEAHGDTHIDDHHTVEDVGITLGQAVAKAVGDRKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNAHHQLETVFKAFGRALRMAVELDERAAGQIPSTKGSL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP1S2_BOVIN
Sequence: MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEDAKEAETPRSVLEEIGLT
What is the function of this protein?
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes.  The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).
What are the official names of this protein?
AP-1 complex subunit sigma-2, Adaptor protein complex AP-1 subunit sigma-1B, Adaptor-related protein complex 1 subunit sigma-1B, Clathrin assembly protein complex 1 sigma-1B small chain, Golgi adaptor HA1/AP1 adaptin sigma-1B subunit, Sigma 1B subunit of AP-1 clathrin, Sigma-adaptin 1B, Sigma1B-adaptin.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein: CHEB1_BURO1
Sequence: MQKIKVLCVDDSALIRSLMTEIINSQPDMTVVATAPDPLVARELIKQHNPDVLTLDVEMPRMDGLDFLEKLMRLRPMPVVMVSSLTERGSEITLRALELGAVDFVTKPRVGIRDGMLDYAEKLADKIRAASRARVRQAPQPQAAARSADSAAAAPMINNPLVSTEKLIIIGASTGGTEAIREVLTPLPPDAPAVLIAQHMPPGFTKSFAQRLNGLCRIAVKEAEHGERVLPGHAYIAPGHAHLLLARSGANYIAQLSDEPPVNRHRPSVDVLFRSAATHAGKNAIGVILTGMGRDGAAGLLEMKRAGAHTFAQDEASCIVFGMPREAIALGGADEVAPLADMSRRVMARLATMGDRVQRV
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 1.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
Protein: GRC3_CANAL
Sequence: MSAFAALKNNPFGESIFNNTSNGDNHSRDDVEEDEVVQYIANSSDEDDDDDNDDNDNDQGNEDNNLFPLEISAPVDTSISSTPAPILNSRITQSNYTPNESNLKFSDNHVTITLNPSEYIIISGQCNLKIIKGSIKINQCHCLTSEDNKSYNIIALQSQSLPIISHYTTPEMEEDGVTSVSIIQLENSFSGIENISQIEPAFKNLISGQPNVEEPSLFKNYSFDIVLTETNGGYGLDINSYWINELNLLKSNKDDPTPKIIMIIGNKNTGKSTFCKSLINELLLTNPNRPVSYLEIDPGQSEYSTPCALSLSEIVQAQFGLAALPHKNNNIVKSRVEHYFGFTSAVNAPTRYVEIIEELFNHHQTKFSQRNHLIINTPGWVKGYGKELLNQITKIINPDKLILLSNNLNQEYPDNANILQDLTYQSLSIIPGVYQLSKYSAPQIRTINKLLYFHQTTTTGTFNFNDHLLDSSPLKISYACGNSPNNPGIYSTTIINHNIDNEFSHRDLCSLVEVSIYGIYSIKSNGNTKFDEMSCFRRDDGNSPFYLNPDDFDNLLSNETITSKFIGLIMVHSINPNDHYMNIYAPDIIINRLRKVLSTNSNQTNDYKLIMIRGEGDIPNCEMLYPEFINKKIDYLKSIKKRKAATTSRKLVDLKLPYISFETKSKVGGIWKVRKNIKRRGHHQKG
What is the function of this protein?
Polynucleotide 5'-kinase involved in rRNA processing.
What are the official names of this protein?
Polynucleotide 5'-hydroxyl-kinase GRC3.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. NOL9/GRC3 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ARGB_ACIB5
Sequence: MPQDQHLGVDKAKILIEALPYIQRFSGKTLVVKYGGNAMTDPELESSFARDIVLLKTVGLNPIVVHGGGPQVDSFLKQLGRESDRIDGMRVTDEATMEVVEMVLGGSVNKSIVNLINKHGGRAIGLTGQDGNLLRARKLLMEKQEEDGSIKHIDLGMVGEVTGVKTDVLEMFTQSDFIPVIAPLGVDEKGNTYNINADLVAGKVAEALGAEKLILLTNISGVLDENKNLLTGLTTQEVDRLIETGVIYGGMIPKVGCALDAVKGGVVSAHIVDGRVPHATLLEIFTDHGVGTLISNRTQTTH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATSE_STAAW
Sequence: MFSKVNNQKMLEDCFYIRKKVFVEEQGVPEESEIDEYESESIHLIGYDNGQPVATARIRPINETTVKIERVAVMKSHRGQGMGRMLMQAVESLAKDEGFYVATMNAQCHAIPFYESLNFKMRGNIFLEEGIEHIEMTKKLTSLN
What is the function of this protein?
Could catalyze the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product.
What are the official names of this protein?
Putative acetyltransferase MW0937, GCN5-related N-acetyltransferase, GNAT.
What is the protein family that this protein belongs to?
Belongs to the UPF0039 (ElaA) family.
Protein: MINC_THEPX
Sequence: MIKEAIKIQGTKEGLVIVLEEDVDIETLKEKIVNRIEKSLKFFEGATLTVRVKSLSVKEEKLQELKDVIFEKYGIEVRIKNFQEKHIKNVTDDEIFNGLEEGITKFHKGTVRSGQVVKYHGNLVIIGDVNPGGLVQAAGNIVVMGTLRGIAHAGFTGNKEAVIVASSLRAMQLRIANVISRAPDKDDASDYPEIAVVKKGKIIVKPLYHLNDLW
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: RL1_AQUAE
Sequence: MARRGKKYIEASKLVDRNKRYTLEEAVDLLKKMEEVLQRRFDETVELAMRLNVDPRYADQMVRGSVVLPHGLGKPIKVVVFAEGEYAKKAEEAGADYVGGDELINKILKEEWTDFDVAIATPEMMPKVAKLGRILGPRGLMPSPKTGTVTTNVEQAIKDAKRGRVEFKVDKAGNVHMPVGKISFEKEKLIDNLYAAIDAVVRAKPPGAKGQYIKNMAVSLTMSPSVKLDINEVLKKLQEKAA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: GUC2D_RAT
Sequence: MAGLQQGCHPEGQDWTAPHWKTCRPCQGPRGLTVRHLRTVSSISVFSVVFWGVLLWADSLSLPAWARETFTLGVLGPWDCDPIFAQALPSMATQLAVDRVNQDASLLLGSQLDFKILPTGCDTPHALATFVAHRNTVAAFIGPVNPGYCPAAALLAQGWGKSLFSWACGAPEGGGALVPTLPSMADVLLSVMRHFGWARLAIVSSHQDIWVTTAQQLATAFRAHGLPIGLITSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTVLLRCARKEGLTDGRLVFLPYDTLLFALPYRNRSYLVLDDDGPLQEAYDAVLTISLDTSPESHAFTATKMRGGTAANLGPEQVSPLFGTIYDAVILLAHALNHSEAHGTGLSGAHLGNHIRALDVAGFSQRIRIDGKGRRLPQYVILDTNGEGSQLVPTHILDVSTQQVQPLGTAVHFPGGSPPARDASCWFDPNTLCIRGVQPLGSLLTLTITCVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTPQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPQSVIQGSTRSVPAFLEHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKMREMRHENVTAFLGLFVGPEVSAMVLEHCARGSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHRHFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSFRPQPAPEELLWTAPELLRGPRRPWGPGKATFKGDVFSLGIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKTGFCRSLPTPLSIQPGDPWQDHINQEIRTGFAKLARVG
What is the function of this protein?
Functions as an olfactory receptor activated by a urine odorant, uroguanylin (PubMed:18178149).  Activated as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (By similarity).  Has guanylate cyclase activity upon binding of the ligand (PubMed:18178149).  Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency.  Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (By similarity).
What are the official names of this protein?
Guanylate cyclase 2D, Guanylate cyclase, olfactory, ONE-GC, Olfactory guanylyl cyclase GC-D, GC-D.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Single-pass type I membrane protein. Note=Colocalized with NCALD at the apical region of the cilia (PubMed:11580282). Coexpresses with PDE2 (By similarity).
Protein: RL7_TRIEI
Sequence: MSAKTDEILEQLKSLSLLEASELVKQIEDAFGVSAAAPAGGMMMPMAMPGAPGAAAAEPEEEQTEFDAILTEFPSDKKIAILKVVRSITGLGLKEAKELVESVPKPLKEGIAKEAAEDIKKQLEEAGAKVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: HEM6_RICB8
Sequence: MNKKNREVTSSWFTNLRDLVCAEFEKIEEEYAKAKGLKPGKFVRSSWERDGGGGGVMSVMKGEVFEKVGVNISTVFGEFSKAFRAEIPGAELDGKFFATGISLVAHLKSPLIPAMHFNTRYIETSKNWFGGGGDLTPFYPEEDETAKFHAAFKEACDKYDSGYYPKFKKQCDEYFYLKHRKEPRGVGGIFYDYLNSGNFEQDFSFTQDVGKALLSVYPEIVRNKLFLPWTDEQKEYQLIRRGRYVEFNLLYDRGTKFGLMTDGNVEAILMSLPPEVKWA
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLME_XYLF2
Sequence: MSHSKSSQRWLKEHFSDPFVKKAQAEGMRSRAAYKLEEILKRDRILRPNMVVIDLGAAPGGWSQQIRKQMGDSGRVIALDIVKMAPLVGIEFLQGDFRDKAVLSQLEIMLKGQPVDLVLSDMAPNKSGIDVMDQPRMMYLAELAMDFADIHVKPGGSFLIKLFHGVGSDGYIRQLRHRYKKVAIRKPLASRKRSPEVYILGDGKLTQNEVSCS
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABR_YERPP
Sequence: MGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEAMVTIVFSAGAEVLDVDIEQRRQLEERLVLQLRMISKGAYYWYRREQEKLAASRVE
What is the function of this protein?
Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis.  By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.
What are the official names of this protein?
HTH-type transcriptional repressor FabR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NODQ_RHIS3
Sequence: MRHIMAKSLAPTDGVRDYLAAQEKKSLLRFLTCGSVDDGKSTLIGRLLSDTKQIFEDQLAALERDSRKHGTTGDDIDFALLVDGLEAEREQGITIDVAYRFFATPKRKFIVADTPGHEQYTRNMATGASTADLAIVLIDARQGVLRQTRRHSIIASLLGIRHIVLAVNKIDLVGFDQAVFERITESYRQFSRDLGFQTIVPIPMSARYGDNVTSRSESMEWYSGPTLIEHLETVSVEEAVVELPFRFPVQYVNRPNLDFRGFAGTVASGSVAPGDEVVVAKSGKSSRVKRIVSYGGDLAQAAAGQAVTLVLDDEVEISRGNMLVSPAARPQVADQFAANIVWFDEHALLPGRSYILRTETDQTSATVTDLKYRINVNDFAHEAAKSLEMNEVGICNISTRSPIAFDTFAENRTTGAFILIDRITNATVGAGMILHSLRRAENIHWQSLDVGKRVRADMKHQRPAVFWFTGLSGSGKSTIANLFEKKLFATGRHTYILDGDNVRHGLNRDLGFTEADRVENIRRVAEVARLMADAGLIVIVSFISPFSAERRMARELMADGEFVEVFVDTPFEECARRDPKGLYARALNGEIKNFTGVDSPYEAPEKPEIHLKTLGRSAEEMVDALEHWLNERDIAQPPPADNGGSI
What is the function of this protein?
APS kinase catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Bifunctional enzyme NodQ, Nodulation protein Q.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Protein: SMAD5_PONAB
Sequence: MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
What is the function of this protein?
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase.  SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity).
What are the official names of this protein?
Mothers against decapentaplegic homolog 5, MAD homolog 5, Mothers against DPP homolog 5, SMAD family member 5, SMAD 5, Smad5.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
Protein: RL22_MYCBP
Sequence: MTAATKATEYPSAVAKARFVRVSPRKARRVIDLVRGRSVSDALDILRWAPQAASGPVAKVIASAAANAQNNGGLDPATLVVATVYADQGPTAKRIRPRAQGRAFRIRRRTSHITVVVESRPAKDQRSAKSSRARRTEASKAASKVGATAPAKKAAAKAPAKKAPASSGVKKTPAKKAPAKKAPAKASETSAAKGGSD
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL36_BIFLO
Sequence: MKVSPSVKRICENCRVIRRHGRVMVICVNPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: RUVB_BORGP
Sequence: MKDENSINFLSSNESYLYDKSENELRPKVFEDFKGQVNVKETLSIFIRASKERGEALDHVFLSGPPGLGKTTLASIIAFEMNASIKITSAPAFDKPKDIIGILTGLDEKSILFIDEIHRLRPIIEEMLCIAMEDYELDWVIGQGANARTVRMPLPKFTLIGATTKPGKVTSPLYARFGITARFELYSEIELVEIIKRNSIILNIEIEEDAAFLLARSSRGTPRIANRLLRRIRDIAQVTGSLVVTSDIVSIGLEMLRIDGEGLDEQDRNILRSLILKFNGGPVGVDTLAISVGETADSLEDFYEPYLIMKGFINRTHRGRKATEFAYLHLNLEMKEEDISENQRVSF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: NCSA_HALVD
Sequence: MECDKCGRDAVMHAAYSGAHLCDDHFCASVEKRVRRRIREDNMLPRDASPENPQTWVIGLSGGKDSVVLTHILDDTFGRDPRIELVALTIHEGIEGYRDKSVDACVELAEDLDIHHELVTYEDEFGVQMDDVVEKDPENMAACAYCGVFRRDLLERFADELGADKLLTGHNLDDEAQTALMNFFEGDLKQVAKHFDASIGDFEKRRDAGEFIPRAKPLRDVPEKEVALYAHLKDLPAHITECPHSSEAYRGEIQQLLLKLEENHPGTRHSIMAGYEELAELTAREYRGEGRVDLNDCERCGSKTAGDVCRKCRLIESIEAV
What is the function of this protein?
Required for thiolation of mcm(5)S(2)U at the wobble uridine position of tRNA specific for lysine (tRNA(Lys)).  Probably acts by catalyzing adenylation of tRNA, an intermediate required for 2-thiolation.  May also act as a sulfurtransferase that transfers sulfur from thiocarboxylated SAMP2 onto the uridine of tRNA at wobble position.  Required for cell growth at elevated temperatures.
What are the official names of this protein?
tRNA 2-thiolation protein NcsA, N-type ATP pyrophosphatase superfamily protein, tRNA adenylyltransferase NcsA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
Protein: SORC_HYPJQ
Sequence: MEPNNHHDGLNGQKADNPLEVAIVGGGLTGLALALGLLRRNVNFTIYERAASFGELGVGIHFTPNAERAMKALDPRILQSYVDVATHAEGGFLSFVDGLHDDDLLFQLRMGEGYKAARRCDIVSQLVKHIPQERVQLLKWLQSVEEDAEGRAVLTFRDGSTAKADVVVGCDGIRSQVRSAMFGSGPSAPRAQYAHQLAFRGLVPMAKVAATLGPEKTSRAIGYLGPGGFVLSVPLAGINMMHLEVFVMDPLPWSDDTTGSKPDKDKDEDDVKRYVLPSTRAEAEKAFTEFNPTVRSLISLLPEELGKWAIFDMLDSPAPSYALGRMCLAGDAAHASTPNQGGGAGAGMEDSLVLAEILAALADRAKSGARVGSWEISEGLKIYSDARYERAQWLVQSSRRVAQLFTRKKGAGQGGEEEEPISREILERSHQLWDYDVDAAVEEALGKLRAKVLEKH
What is the function of this protein?
FAD-dependent monooxygenase; part of the SOR gene cluster that mediates the biosynthesis of sorbicillinoids, a diverse group of yellow secondary metabolites that restrict growth of competing pathogenic fungi but not of bacteria (PubMed:29104566).  Sorbicillinoids biosynthesis requires the action of two PKSs (PubMed:28809958).  The SOR cluster is required for the production of trichodimerol and dihydrotrichotetronin, with sor2 being sufficient for production of trichodimerol, but not dihydrotrichotetronin in the light (PubMed:28809958).  Sor1 iteratively combines three acetyl units and the growing chain is modified by the ketoacyl reductase subunit, and optional by the enoyl reductase subunit in the second cycle (By similarity).  The polyketide is then handed over to the PKS sor2, which adds three more acetyl units, and two methyl groups (By similarity).  Sor2 releases an aldehyde, which undergoes spontaneous cyclization resulting in the formation of sorbicillin or 2',3'-dihydrosorbicillin (By similarity).  The monooxygenase sor5 oxidizes sorbicillin and 2',3'-dihydrosorbicillin to 2',3'-dihydrosorbicillinol and sorbicillinol, respectively (PubMed:29104566).  The oxidoreductase sor8 further converts sorbicillinol into oxosorbicillinol (PubMed:29104566).  Sorbicillinol is the building block for the other sorbicillinoids such as disorbicillinol, bisvertinolon, dihydrobisvertinolone, and dihydrotrichotetronine (PubMed:29104566, PubMed:28809958).
What are the official names of this protein?
FAD-dependent monooxygenase sor5, Sorbicillinoid biosynthetic cluster protein 5.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TSAC_STRMK
Sequence: MKELTLDSAVATLRAGGVIAYPTEAVWGLGCDPSHEAAVHMVLRLKQRPIEKGMILVAADLAQLEGWVRLQALPDARQRAVLASWPGANTWILPAGPRAQPWVTGEHSGIAVRISAHPLVAELCRAWGGPLVSTSANLAGEPPARRREELDPRLLRLLDGILDGETGGLAQPTPIRDALSGNVLRS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI2_METMP
Sequence: MNNNSIEYRKLEHLIVCDHCDVEYKKGTLLEDVELIHSGISNCDLDDIDTSIEIFGKKLNAPLIVAAITGGHPKAKEVNKNIAIAVEELNLGMGVGSQRAAISKSYLEDTYSVVRDHTSSLIIGNLGAVNFVEDSWDEEIISKSVEMIDADAMAIHFNPLQEAIQPEGDVNFKGLNILKEIISNYNKIHGKIPFIAKQVGEGFSKKDAIFLKEIGFDAIDVGGSGGTSWAAVELYRIKDEEQKNFSNQYFNWGIPTAASILEVNSAFSGPIIATGGIRTGIDIAKSISIGANCCGTALPILKAALKSSEAVTTVLERMIKELKTTMFLTGCNNINELKSARYILKGDLKNWKDQI
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.