PharMolix/UniProtQA huggingface dataset:
Protein: PURL_RHIME
Sequence: MTISNTRPITPDLIASHGLKPDEYERILNLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGVVDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVAAMNALRFGSPDHPKTRHLVSGVVAGVGGYGNSFGVPTVGGEVEFDARYNGNILVNAFAAGLAKTDAIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTVQVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMTAYEMMLSESQERMLMVLRPEKEEEAKAIFVKWGLDFAIVGKTTDDLRFRILHQGEEVANLPIKELGDEAPEYDRPWTPARAPSPLATNDVPQADVSDALLKLVGSANNSSRRWVYEQYDTLIQGNSLQLPGGDAGVIRVEGHETKALAFSSDVTPRYVEADPFEGGKQAVAECWRNLTATGALPLAATDNLNFGNPERPEIMSQLVHAIKGIGEACQALDFPIVSGNVSLYNETNGQAILPTPTIGGVGLVRDWSKMARIRFAAANETILLAGAPESWGTHIGQSVYMRDIHGRTDGPAPHVDLGHERKVGDFVRGLIEDGLVTAVHDCSSGGLALAVAEMAIASGIGATIDAPAEHDPIPVFYGEDQGRYVVTVAEGSAETVAARAKAAGVALPVIGRTGGNAVQLGDARPVSVDELRSAHEAWFPNYMGGDLAPDN
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TECRL_MOUSE
Sequence: MFKRHKSLERKRELLFQGLPQSTMKNNARNFHSLSQLVLSAGPLKTTTAVKHSKTTHFEIEILDAHTRKQICIVDKVTQTSTIHDVKQKFHKACPKWYPSRIGLQLEYGGPYLRDYITVQSVAASSIITLYFTDLGQQVGWTTVFLAEYSGPLLIYLLFYLRSSYIYDVKESTRWPRHPVVHLAFFCHCIHYIRLLLETLFVHKVSTGHSPMKNLIKGCAFYWGFTSWMAYYINHPRYTPPSFGNRQVIVSAINFLFCEAGNHFINTVLAHPNHTGSNACFPSPNYNPFTWLFFLVSCPNYTYEIGSWISFTVMTQTLPVGIFTILMTIQMSLWARKKHKIYRKKFNSYVHRKSAIIPLIL
What are the official names of this protein?
Trans-2,3-enoyl-CoA reductase-like, Steroid 5-alpha-reductase 2-like 2 protein.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Protein: THIG_ACIBY
Sequence: MQDTPLIIGSRSFQSRLLVGTGKYKDLNETDLAIQASGAEIVTVAIRRVNIGQNPDQPNLLSVIPPEKYTILPNTAGCFDADSAVRTCMLARELLDGHNLVKLEVLGDEKTLYPNVTETLKAARTLIDDGFEIMVYTSDDPIIAQELESMGCVAIMPLGSLIGSGLGILNPHTISIIKENAKVPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAAAQNPILMASAMKKAVEAGREAFLAGRMPRKRMANASSPETGYFFK
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_LEGPC
Sequence: MNKQNARHRRGLKAKALIRKTGRSRLVVYRSGVHIYSQIVKSDQLGDKVLVASSTIDKELRSSLTGKSKVEQASLVGQLLGKRAKAAGITQVAFDRAGYKYHGRVKALAEGAREAGLDF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: YG5X_YEAST
Sequence: MAVKHKSESLKHEEGAAKKAKTGLLKLKKIMDIESNVVKYSICIPTTVIDNCNNLEQVTFTAYQIARTAVLFNVQEIIVLDQSKDKKHEKKSRSKETISDCLLLATLLQYFVTPPNLLDTTFKKKNKLYLKCASTFPPLNQLPFMNASAEQHYKEGLSIARDSSKGKSDDALTNLVYIGKNQIITLSNQNIPNTARVTVDTERKEVVSPIDAYKGKPLGYHVRMASTLNEVSEGYTKIVWVNSGDFHYDEELSKYHKVETKLPYIAKLKKSSTSEKPCNILLIFGKWGHLKRCFRRSDLESSSLHHYFSGQLQFPASVPQGNIPIQDSLPIALTMFQRWAS
What are the official names of this protein?
Putative methyltransferase YGR283C.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MCPH1_PONPY
Sequence: MAAPILKDVVAYVEVWSSNGTENYSKTFTTQLVDMGAKVSKTFNKQVTHVIFKDGYQSTWDKAQKRGVKLVSVLWVEKCRTAGAHIDESLFPAANTNEHLPSLIKKKRKCMQPKDFNFKTPENDKRFQKKFEKMAKELQRQKTSLDGGVPILLFESNGSLIYSPTIEINSSHHSAMENRLQEMKEKRENLSPTSSQMIQQSHDNPSNSLCEAPLNISHDTLCSGESFAGGLHSSFDDLCGNSGCGNQERKLGGSINDIKSDMCISSLVLKANNTHSSPSFTHLDKSSPQKFLSNLSKEEINLQRNIAGKIVTPDQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSHGSHSPPKEKCKRKRSIRRSIMPRLQLCRSEGSLQHVAGPALQALSCGESSYDDYFSPDNLKERNSENLPPESQLPSSPAQFSCRSLSKKERTSIFEMSDFSCVGKKTRTVDIISFTAKTISSPQKTGNGEGLATLSCVTSEESSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPVLPKGHDGDLTPLEGNLEEVKEAVGLKSTQNKGTTSKISNSSEGEAQSEHEPCFIGDCNMETSTEEKENLPGGYSGSVKNRPTRHDVLDDSCDGFKDLIKPHEELKKSERGKKPTRTLVMTSMPSEKQNVIIQVVDKLKGFSIAPDVCETTTHVLSGKPLRTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFELSNHFPAAPLCRSECHLSAGPYRGTLFADQPVMFVSPASSPPVAKLCELVHLCGGRVSQVPRQASIVIGPYSGKKKATVKYLSEKWVLDSITQHKVCASENYLLSQ
What is the function of this protein?
Implicated in chromosome condensation and DNA damage induced cellular responses.  May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity).
What are the official names of this protein?
Microcephalin.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: PUR7_STAA1
Sequence: MTLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGIESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYKNDALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLKQLMDAMNLKLVDFKIEFGKTETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: SPP_ORYSI
Sequence: MASFPSPPLAAAAAAAPPRLAPGLPLAAAAVRRPSSLARRSSIALAAPANPLRCIHRRAVSPRLRRRTEAVGAASAAIGSLGEEREGCLSCFPRGRRRGRPGLARFAPCALPHTYGLSSLHSGLTGAKIRRRHVLHAAGPDEPHVASPTWSETALDKHYVDQPIGKEELEGFLNTPLPSHPKLVRGQLKNGLRYLILPNKVPANRFEAHMEVHVGSIDEEEDEQGIAHMIEHVAFLGSKKREKLLGTGARSNAYTDFHHTVFHIHSPTKTKEYGEDLLPSVLDALNEIAFHPKFSSSRVEKERRAILSELQMMNTIEYRVDCQLLQHLHSENKLSERFPIGLEEQIHKWDPDKIRRFHERWYYPANATLYLVGEINDIPRAIREIEAVFEHTLPEGEAAPMSTASPFGAMASLFAPKLPGGLAASLTGERSPAADKIKPVKRERQAIRPPVEHKWSLPGVAQDAKPPAIFQHELIQSFSINMFCKIPVNQVQTYKDLRSVLMKRIFLSALHFRINTRYKSSNPPFTSVELDHSDSGREGCTVTTLTVTAEPQNWRSAIKVAVHEVRRLKEFGVTMGEMTRYMDALIKDSEQLAMMIDSVPSVDNLDFIMESDALRHTVMDQLQGHESLLAVAETVTLEEVNTVGAEVLEFISDYGKPDAPLPAAIVACVPKKVHMDGVGETDFEIHPEEITDSIKAGLEEPIYPEPELEVPKELITQSELEDLKLQRKPSFASLSKEENVVKIFDDETGIAQRRLSNGISINYKITQNEARVGVMRLIVGGGRATEDSESKGSVIVGVRTLSEGGCVGNFSREQVELFCVNNLINCSLESNEEFIFMEFRFALRDNGMRAAFQLLHMVLEHNVWLEDAFDRATQLYLSYYRSIPKSLERSTAHKLMLAMLNHDERFVEPSPHSLQKLTLQSVKDAVMNQFVGDNMEVSIVGDFTEEEVESCVLDYLGTVSAPKSSKTQEHIEKISFLPFPSDLHFQQVYIKDTDERACAYIAGPAPNRWGFATEGNDLFNVIRSSSGDAQVSESANTDLTERKHNDVRSHSLFFGITLSLLAEIINSRLFTTVRDSMGLTYDVSFELNLFDKLDLGWYVIAVTSTPSKVHKAVDACKGVLRGLHSNKIVERELDRAKRTLLMKHEAETKTNAYWLGLLAHLQSSSVPRKEISCIKELTMLYESATIEDLYLAYEHLKVDESSLFACIGIAGAESGEETTDDELDMGLHGMGPIGGRGLSTMTRPTT
What is the function of this protein?
Cleaves presequences (transit peptides) from chloroplastic protein precursors.  Initially recognizes a precursor by binding to the C-terminus of its transit peptide and then removes the transit peptide in a single endoproteolytic step.  In a next step, pursues the cleavage of transit peptide to a subfragment form.
What are the official names of this protein?
Stromal processing peptidase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RL32_XYLFM
Sequence: MAVQKSRVTPSRRGQRRSHDALAAKKLSIDPTSGEVHIRHHVTADGYYRGKKVIAIKASVVEED
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RLME_YERPS
Sequence: MSNKKRSASSSRWLQEHFSDKYVIQAQKKGLRSRAWFKLDEIQQSDKLFKQGMTVVDLGAAPGGWSQYAVTQIGSKGRVIACDLLPMDPIVGVDFLQGDFRDELVLKALLERVGDKKVQVVMCDMAPNMSGTPAVDIPKSMYLVELALDMCRDVLAPGGSFLVKVFQGDGFDEYLREIRSLFTKVKIRKPDASRARSREVYIVATGRKL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPT_ECO57
Sequence: MYRIVLGKVSTLSAAPLPPGLREQAPQGPRRERWLAGRALLSHTLSPLPEIIYGEQGKPAFAPETPLWFNLSHSGDDIALLLSDEGEVGCDIEVIRPRANWRWLANAVFSLGEHAEMDAVHPDQQLEMFWRIWTRKEAIVKQRGGSAWQIVSVDSTYHSSLSVSHCQLENLSLAICTPTPFTLTADSVQWIDSVN
What is the function of this protein?
May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E. coli.  The native apo-protein substrate is unknown.  Is able to functionally replace AcpS in vivo but only when expressed at high levels.
What are the official names of this protein?
4'-phosphopantetheinyl transferase AcpT.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
Protein: MATK_CERBE
Sequence: MEEFQGYLELDRSQQHDFLYPLIFREYIYALAHDHGLNRSILLDNVGYDNKSSFLIIKRLISRMYQQNHLIISPNDSNQKKIGGYNKNLYCQMISEGFAVIVEIPFSLRLVSSLEGTEIVKSYNLRSIHSIFPFLEDKFSHLNYVSDVLIPYPIHLEILVQTLRYWAKDPSYLHLLRLFLHDYYNLNSLITKNKSIFSKSNPRLFLLLYNSYVCEYESILLFLRNQSSHLQFTSSWIFFERIHFYEKIKYPVEEVFANDFPAILWFFKDPFMHYVRYQGKSILASKDTPLLMNKWKYYLVNLWQCHFYVWSQPGRIYINQLSKHSLDFLGYLSSIRPNLSVVRSQMLENSFIMDNARKKFDTLVPIIPLIGSLAKVKFCNALGHPISKSTWADSSDFDIIDRFVRICRNLSHYYSGSSKKKSLYQIKYILRLSCVKTLARKHKSTVRTFLKRLGSKLLEEFFTEEEQILSLIFPRASSTLTRFYRGRIWYLDIFCINDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BOREA_MOUSE
Sequence: MAPKKRSSRGTRTNTLRSRKLASFLKDFDREVQVRTKQIESDRQTLLKEVENLYNIEILRLPKALQGMKWLDYFALGGNKQALEEAAKADRDITEINNLTAEAIQTPLKSVKKRKVIEVEESIKEEEEEEEEGGGGGGRTKKSHKNLRSAKVKRCLPSKKRTQSIQGRGRSKRLSHDFVTPAMSRLEPSLVKPTPGMTPRFDSRVFKTPGLRTPAAKEQVYNISINGSPLADSKEISLSVPIGGGASLRLLASDLQRIDIAQLNPEALGNIRKLSSRLAQICSSIRTGR
What is the function of this protein?
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.  The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.  In the complex, it may be required to direct the CPC to centromeric DNA.  Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment (By similarity).
What are the official names of this protein?
Borealin, Cell division cycle-associated protein 8, MESrg.
What is the protein family that this protein belongs to?
Belongs to the borealin family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells.
Protein: WSCD1_RAT
Sequence: MAKPFFRLQKFLRRTQFLLLFLTAAYLMTGSLLLLQRARVALPQALRAPGSLQALPVATVALGVGLLDSRSLHDPHSSPDLLLDVDTLRSPLARVPPGIRWPRRNRSSLRRRWLHHLTSDPQGPPTLGPEASGPASHNQGNYLGCFSEEGQERTLKGAVFYDLRKMTVSHCQEACAERSYVYAGLEAGAECYCGNRLPATRVSLKECNQECKGEKGSMCGALHRLSVYSVGLQQSGAKKRWTATYRGCFPLPENITRTFSSSMTQANVTVETCSGFCSQKEFPLAILRGWACYCAYPTPQFSLRDAVDGALCSQGTEAQGLPGYCEVYQTPVQDTRCTDRKFLPNKSKVFVALSSFPGAGNTWARHLIEHATGFYTGSYYFDGTLYNKGFKGEKDHWRSRRTICVKTHESGRREIEMFDSAILLIRNPYRSLVAEFNRKCAGHLGYAPDRNWKSKEWPDFVNSYASWWSSHVLDWLKYGKRLLVVHYEELRHSLVPTLREMVAFLNVSVSEERLLCVENNKEGSFRRRGRHPHDQEPFTPEMKDLINGYIRTVDQALRDHNWAGLPREYVPR
What is the function of this protein?
Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
What are the official names of this protein?
Sialate:O-sulfotransferase 1, WSC domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the WSCD family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ULAK_MOUSE
Sequence: XXNERKVIQ
What are the official names of this protein?
Unknown protein from spot 2D-0014LD of 2D-PAGE of liver tissue.
Protein: RK3_BIGNA
Sequence: MFQSSRLVALGLCAALVLVGGSIILSGLSPNLSSPMAAAARASSSALVALPGGRMIEVPHMTKDYRDVKVCSRQRKWEIREHMRDPIKMGLMGTKAGMTTYYDDEGIAHPVTVIALEAGNVVTQVKTKETDGYDAVQLAYKETRDRTIPWPERQHLRKHGNVKAMKHLKEFKIADVSEFTPGQQLKAEELFEVGDLVDVSGTSSGKGFQGSIRRWGMKRGPMSHGSKSHRQHGSIGCSATPSRVYKGLKMAGRMGNERKTVKKLPVMMVNDEEKYIVVRGSVPGKKGTIVELRPTKIVGKHC
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: COX3_MAGGR
Sequence: MNNLVRSNFQDHPFHLVSPSLWPLYTSISLLVLTSNAALAMHNFANGHYSVYLGLILVISSMSFWFRDVITEGSFLGDHTLAVQKGLNLGVILFIVSEALFFMAIFWAFFHSALTPTVELGGQWPPIGIEPINPFELPLLNTVILLSSGATVTYAHHSIIGRNREGALYGSVATVLLAIVFTGFQGVEYSVSSFTISDGAFGTCFYFGTGFHGLHVIIGTIFLLVALWRIFAYHLTDNHHLGFEAGILYWHFVDVVWLFLYISIYYWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TCF7_MOUSE
Sequence: MPQLDSGGGGAGRGDDLGAPDELLAFQDEGEEQDDKNRDSPVGPERDLAELKSSLVNESEGAAAGAGVPGPGVRVHGEAEGAPEALGREHTSQRLFPDKLPESLEDGLKAPECTSGMYKETVYSAFNLLMPYPPASGAGQHPQPQPPLHNKPGQPPHGVPQLSPLYEHFSSPHPTPAPADISQKQGVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWPSPPLYPLSPSCGYRQHFPAPTAAPGAPYPRFTHPSLMLGSGVPGHPAAIPHPAIVPSSGKQELQPYDRNLKTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTGGKRNAFGTYPEKAAAPAPFLPMTVL
What is the function of this protein?
Transcriptional activator involved in T-cell lymphocyte differentiation.  Necessary for the survival of CD4(+) CD8(+) immature thymocytes.  Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role.  Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene.  Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (PubMed:17218525).  Inhibits the developmental program of IL17A effector gamma-delta T-cell subsets via regulating the transcription of T-cell lineage effector proteins (PubMed:23562159, PubMed:30413363).  Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (PubMed:23562159).  TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1 (By similarity).  May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
What are the official names of this protein?
Transcription factor 7, TCF-7, T-cell-specific transcription factor 1, T-cell factor 1, TCF-1.
What is the protein family that this protein belongs to?
Belongs to the TCF/LEF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMH_BACC1
Sequence: MFNHVTVLLKETVDGLDIKPGGTYVDCTLGGGGHSSYLLSQLTEGGRLIAFDQDEIAIQNAKEKFSSYGEQFITVKSNFRYLSEKLQELGITEVDGILFDLGVSSPQLDTPERGFSYHHDAPLDMRMDQDAPLTAYDVVNSWSYEQLVRIFFQYGEEKFSKQIARKIEAYRENKAIETTGELVELIKEGIPAPARRTGGHPAKRVFQAIRIAVNDELKVFEEALESAIEMVKPGGRVSVITFHSLEDRICKTTFKRNSTTPQLPPGLPIIPDEFKPKLKLITRKPILPSDIELEENNRARSAKLRIAEKR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_PHEZH
Sequence: MSTPPPKLLRALAGETLERPPIWFMRQAGRSLPEYRELRSRAKDFIAFCLDPEMAAEATLQPMRRFPMDGAIVFADILLIPLALGQDVWFEAGEGPKLGELPPIEALRDQVEASTGRLSAVGETLARVRAELEPDRALIGFAGAPWTVATYMLERKGSEREAARAYAYAHPDELDALLDVLVDATARYLVMQAKAGAQALKLFESWAESLSEDVFERIVVRPHAAIVEKVRAAGVTVPIIGFPRGAGAQVETYAEGVPVEGIALDVQATAALGRRLQAQGRCIQGALDNLLLREGGPALDARVDQLLAQWGDGPWIFNLGHGVLPDTPIENIARVVSRVTGKPVR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_EXISA
Sequence: MIVGIGVDIVELDRMARSMKQPRFLKRLLTDAEYELSQQYPLPRQIEFVSGRFAAKEAYAKAIGTGIAHGLSWRHIEILPDETGRPVMTAPFVGKIHVSISHSQTYAIAQVILEEEGHHVSS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_ECOUT
Sequence: MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGGLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWVNDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAAD_MOUSE
Sequence: MGKTISLLISVVLVAYYLYIPLPDAIEEPWKVVWETAFVKIGTDLASFGELLGISHFMETIQLLMSFQEVPPTSDEHVTVMETAFDSVPVRIYIPKRKSMALRRGLFYIHGGGWCLGSAAHFSYDTLSRWTAHKLDAVVVSTDYGLAPKHHFPRQFEDVYRSLRWFLQEDVLEKYGVDPRRVGVSGDSAGGNLAAAVTQQLIQDPDVKIKLKVQALIYPALQALDTNVPSQQEGSHFPVLTRSLMVRFWSEYFTTDRGLEKAMLLNQHVPMESSHLLQFVNWSSLLPERYKKSPVYKNPTPGSSELAQKYPGFIDVKACPLLANDNILHHLPKTYIITCQYDVLRDDGLMYVKRLQNVGVHVTHHHVEDGFHGTFSFPGLKLSERMKNQYLSWLIKNL
What is the function of this protein?
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity).  Displays serine esterase activity in liver.  Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
What are the official names of this protein?
Arylacetamide deacetylase.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
Protein: Y1557_THEMA
Sequence: MKRDGGRLLPRERMIKAGPESLSVEELVAIVLRTGKKGKHVLELSKDLLERFDGSLIKLSNASLEEIASVEGVGMVKAITLKAALELGKRLHRELERIPEKLDSSVKVYKYCQEMVYLEREIVKVICLDTKLNVIGENTLTVGTSDRSLIHPRDVFRTAIRANASGVIVVHNHPSGDPTPSKEDRLITERLKQAGEILGVSLVDHVIVSRRGYFSFREEGEL
What are the official names of this protein?
UPF0758 protein TM_1557.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: ARF1_RAT
Sequence: MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQK
What is the function of this protein?
Small GTPase involved in protein trafficking between different compartments (By similarity).  Modulates vesicle budding and uncoating within the Golgi complex (By similarity).  In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity).  The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity).  The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (PubMed:23889934).
What are the official names of this protein?
ADP-ribosylation factor 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasm, perinuclear region. Synapse, synaptosome. Postsynaptic density. Membrane; Lipid-anchor. Golgi apparatus, trans- Golgi network membrane; Lipid-anchor.