PharMolix/UniProtQA huggingface dataset:
Protein: MNTP_NEIMB
Sequence: MGFYALLLIALGMSMDAFAVALAKGAAVRMPPRKIAATALVFGTVEALTPLAGWVGGFYAKPFISEWDHWVAFVLLGGLGLKMMREGLSGEAEDVRESKRESLWMTVLTAFGTSIDSMIVGVGLAFMEVNIAFAAAIIGMATTVMVAVGLTAGRALGVLFGRCAEFAGGLVLIAIGTWTLLSHLGLIQ
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENO_ECO5E
Sequence: MSKIVKIIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVAAVNGPIAQALIGKDAKDQAGIDKIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: BOML2_BOMVA
Sequence: QSFGNQWARGHFM
What is the function of this protein?
Possesses insulin-releasing activity.
What are the official names of this protein?
Bombesin-like peptide 2.
What is the protein family that this protein belongs to?
Belongs to the bombesin/neuromedin-B/ranatensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPXC_CUPMC
Sequence: MLKQRTIKSLVKTVGIGLHSGRKVTLTLRPAPADTGIVFTRVDLPEAVEIHAAASAIGDTRLASVLQKDGARVSTVEHLMSACAGLGVDNLYVDVDAEEIPIMDGSAASFVFLLQSAGMEEQPAAKRFIRVKKAVEVRDGDKLARLEPFFGFKLAFTIDFRHPAVDKTGQTFTIDFADTSYVREIARARTFGFAHEVEALREMGLARGGSLDNAIVLDEHRMLNNEELRYGDEFVRHKILDAIGDLYVIGHPLIASYVAHKSGHGMNNQLLRALLADQEAYEFVTFDKVEEAPVAFLPQAQPAFA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: RL24_PSYWF
Sequence: MAKLRKGDNVIVIAGKDKGKQGTVLAVKNDRIKVEGINIVTKHQKPNAATGAEGGIVKQEAFLHISNVAIFNAQTQKADRITYQFDDEGNKKRVYRSNGEVVATA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: MTG1_AEDAE
Sequence: MSNAFRTVFPTVNRELLNWFPGHMGKGMKQMQQKLKQVDCVIEVHDARIPLSGRNSEFRYTISGVKPHILVLNKKDKIDRRLQGRVVDRLQQEDSEARHILFTNCKDQSCNGIRKVMPLAQDLILSSNRFNRADQKEYCIMIIGVPNVGKSSLINVLRNRHLNKKGASQVGAVAGITRSVLNKIKISEDPLVYLLDTPGILKPNIADTETGLRLALVSCLQDHLVGEELIADYLLYLLNKRGNFKYVELMGLKEPTDSIAEVLIAGSKHLDKTVRVRHYDGSFVIRPDAMLAARHMIKAFRTGAFGKILIDDDKFV
What is the function of this protein?
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity).  Displays mitochondrial GTPase activity (By similarity).
What are the official names of this protein?
Mitochondrial GTPase 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: VE7_HPV42
Sequence: MRGETPTLKDIVLFDIPTCETPIDLYCYEQLDSSDEDDQAKQDIQRYRILCVCTQCYKSVKLVVQCTEADIRNLQQMLLGTLDIVCPLCARVE
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: NQOR_PSEAE
Sequence: MSSPYILVLYYSRHGATAEMARQIARGVEQGGFEARVRTVPAVSTECEAVAPDIPAEGALYATLEDLKNCAGLALGSPTRFGNMASPLKYFLDGTSSLWLTGSLVGKPAAVFTSTASLHGGQETTQLSMLLPLLHHGMLVLGIPYSEPALLETRGGGTPYGASHFAGADGKRSLDEHELTLCRALGKRLAETAGKLGS
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: MSMB_METHY
Sequence: MDIQTEMTAPPLSGGLDPAQARDAADAVRNAIYRATILLDSQKWDEWLALCADNFVYDIKAWSPEINYDMTYLHGSRKDLEALIRLLPKHNTDHSPLTRHTTIYTVDVADEGATAKGVSAFIVFQHLLDGTNSHIDAGESRLFLVGKYYDTFRIENGQALFTSRETRLENRRLDKGSHWPI
What is the function of this protein?
Methanesulfonate monooxygenase (MSAMO) mediates the primary degradation of methanesulfonic acid (MSA) to produce formaldehyd and inorganic sulfite by initial hydroxylation of the carbon atom prior to spontaneous cleavage of the unstable hydroxymethanesulfonic acid.  MSAMO has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methane- to butanesulfonate) and excludes all larger molecules, such as arylsulfonates and aromatic sulfonates.  All MSAMO components are required for enzyme activity.
What are the official names of this protein?
Methanesulfonate monooxygenase hydroxylase subunit beta, Methanesulfonic acid monooxygenase hydroxylase small subunit, Methanesulfonic acid monooxygenase hydroxylase subunit beta, MSA monooxygenase hydroxylase subunit beta, MSAMO hydroxylase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FDH_HORVU
Sequence: MAAMWRAAARQLVDRAVGSRAAHTSAGSKKIVGVFYQAGEYADKNPNFVGCVEGALGIRDWLESKGHHYIVTDDKEGFNSELEKHIEDMHVLITTPFHPAYVTAEKIKKAKTPELLLTAGIGSDHIDLPAAAAAGLTVARVTGSNTVSVAEDELMRILILLRNFLPGYQQVVKGEWNVAGIAHRAYDLEGKTVGTVGAGRYGRLLLQRLKPFNCNLLYHDRLQINPELEKEIGAKFEEDLDAMLPKCDVVVINTPLTEKTRGMFNKEKIAKMKKGVIIVNNARGAIMDTQAVADACSSGHIAGYGGDVWFPQPAPKDHPWRYMPNHAMTPHISGTTIDAQLRYAAGVKDMLDRYFKGEEFPVENYIVKEGELASQYK
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide.  Involved in the cell stress response.
What are the official names of this protein?
Formate dehydrogenase, mitochondrial, FDH, NAD-dependent formate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UL24_EHV4
Sequence: MKRKQRLTARSRLRAGIRCHNRFYNAMVQDLASAKKNGVYGARLAPLFSELVPAETLKTAMGVSLAFEVNLGQRRPDCVCTVQFGHGSDAKGVCILIELKTCRFSKNMNTASKNLQRKGGMRQLHDSCRLLAKTLPPGSGEILLAPVLVFVAQRGMRVLRVTRLSPQVVYSNAAVLSCTISRLAEYSPPISERSTRRRCVTRRTNSKAFRAKTTTGSIQPITQAKPAATAAVASLFSATAQANTTNAAVGYQPATISLANPLAWVASLFAPK
What is the function of this protein?
May participate in nuclear egress of viral particles.  Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1.  Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli (By similarity).
What are the official names of this protein?
Protein UL24 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL24 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus, host nucleolus. Host Golgi apparatus.
Protein: EX7S_LEVBA
Sequence: MSEEQPTFEENLATLETIVAQLEQGDIPLEQALTQFQKGVALSKELQTTLQDAEKTLTTMMNDSDQEVAFETPQGGTGDAD
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_OCEIH
Sequence: MKEELHAIRDEAIASVEEAKDMKSLQDLKVKYLGKKGSLTSVLRGMGKLSKEERPVIGEIANQVREQITAALDQKTEKMEEEALNEKLEKETIDVTLPGNPVHIGGKHLLTRVVEEIEDLFIGMGYEVKEGPEVETDYFNFEALNLPKNHPARDMQDTFFITNELLLRTQTSPVQARTMQAYNGEKPIKMICPGKVYRRDTDDATHSHQFRQIEGLVIDKDITLSDLKGTLDIFAKKMFGEDREIRLRPSFFPFTEPSVEMDVSCKVCSGQGCSVCKQTGWIEILGGGMVHPRVLEMSGYDPKVYSGFAFGMGQERIAMLKYGVNDIRHFYTNDIRFLTQFHQA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_XANAC
Sequence: MTSYSFTEKKRIRKDFGKQRSILEVPFLLAIQVDSYREFLQEDVEPNKRKDLGLHAALKSVFPISSYSGNAALEYVGYKLGQPVFDERECRQRGMSYGAPLRVTVRLVIYDRESSTKAIKYVKEQEVYLGEIPLMTGNGTFIVNGTERVIVSQLHRSPGVFFDHDRGKTHSSGKLLYSARIIPYRGSWLDFEFDPKDALFTRIDRRRKLPVSILLRALGYSNEEMLAEFFEINTFHINPDEGVQLELVPERLRGETLNFDLADGDKVIVEAGKRITARHVKQLEAAGVAALAVPDDYLVGRILSHDVVDGSTGELLANANDEINEDQLAAFRKAGVDAVGTLWVNDLDRGPYLSNTLRIDPTKTQLEALVEIYRMMRPGEPPTKEAAQNLFHNLFFTFERYDLSTVGRMKFNRRVGRKDVLGESVLYDKKYFAERNDEESKRLVAEHADTSDILEVIKVLTEIRNGRGVVDDIDHLGNRRVRSVGEMAENVFRVGLVRVERAVKERLSMAESEGLTPQELINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEVTHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCTIETPEGPNIGLINSLAVFARTNQYGFLETPYRKVLDGKVSDDVEYLSAIEENEYVIAQANALTDAKNMLTEQFVPCRFQGESLLKPPSEVHFMDVSPMQTVSVAAALVPFLEHDDANRALMGANMQRQAVPTLRSQKPLVGTGIERAVARDSGVTVNALRGGVIEQIDAARIVVKVNEAEIGGGTDAGVDIYNLIKYTRSNQNTCINQRPLVNVGDVIARGDVLADGPSTDIGELALGQNMLIAFMPWNGYNFEDSILLSERVVEEDRYTTIHIEELTCVARDTKLGPEEISADIPNVSEQALNRLDESGVVYIGAEVRAGDIMVGKVTPKGESQLTPEEKLLRAIFGEKASDVKDSSLRVPPGMDGTVIDVQVFTRDGIEKDKRARQIEESEIKRVKKDFDDQFRILEAAIYARLRSQIVGKVANGGANLKKGDTVTDAYLDGLKKSDWFQLRMKDEDAADAIERAQKQIQAHEKEFEARFADKRGKITQGDDLAPGVLKMVKVFLAVKRRIQPGDKMAGRHGNKGVVSNVVPVEDMPYMATGESVDIVLNPLGVPSRMNIGQILEVHLGWAAKGLGRKIQRMLEAQAAVSELRKFLNDIYNHDNAINAQRVDLSQFSDEELLNLGKNLIDGVPMATPVFDGASEAEIKRMLELADLPQSGQTQLYDGRTGEAFDRKTTVGYMHYLKLNHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVQGRNQMYKNIVDGEHEMVAGMPESFNVLVKEIRSLAINMELEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: OBG_STAHJ
Sequence: MFVDQVTISLKAGDGGNGITAYRREKYVPFGGPAGGDGGKGASVVFEVDEGLRTLLDFRYQRHFKAKKGENGQSSNMHGRGADDLVLKVPPGTIIKSVETDEVLADLVEDGQRAVVARGGRGGRGNSRFATPRNPAPDFSENGEPGEELDVTLELKLLADVGLVGFPSVGKSTLLSIVSKAKPKIGAYHFTTIKPNLGVVSTPDNRSFVMADLPGLIEGASDGVGLGHQFLRHVERTKVIVHMIDMSGSEGRDPFDDYQIINKELVNYKQRLEDRPQIVVANKMDMPDAQDNLTLFKEQVDDSVTIIPVSTITRDNIEQLLYAIADKLDEVKDIDFSVDNDEEIGVNRVLYKHTPSQDKFTITRDDDGAYVVSGNAIERMFKMTDFNSDPAVRRFARQMRSMGIDDALRERGCSNGDIVRILGGEFEFVE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APEB_PSEPW
Sequence: MREALNTGLIDFLKASPTPFHATASLALRLEAAGYQRLDERDSWATVPGGRYYVTRNDSSIIAINLGKQAPLQGGIRMVGAHTDSPCLRVKPQPELQRQGFLQLGVEVYGGALLAPWFDRDLSLAGRVTFRRDGKVESQLIDFKLPIAIIPNLAIHLNRTANEGWQINPQNELPPILAQVAGDERIDFRALLTEQLAREHQLNADVVLDYELSFYDTQDAALIGLNSDFIAGARLDNLLSCYAGLQALLAADSDETCVLVCNDHEEVGSCSACGADGPMLEQTLQRLLPDGDTYVRTIQRSLMVSADNAHGVHPNYADKHDGNHGPKLNAGPVIKVNNNQRYATNSETAGFFRHLCMAEEVPVQSFVVRSDMGCGSTIGPITASHLGVRTVDIGLPTFAMHSIRELCGSHDLAHLVKVLTAFYRSRELP
What are the official names of this protein?
Probable M18 family aminopeptidase 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M18 family.
Protein: RHAM_LISIN
Sequence: MERVASIMYLYPGNQEEYKKRHDELWPEMKEALKAHGAANYSIFLEEKTDTLFAYVEVEDKAIYDKIAETEICQKWWKYMAPIMKSNPNNSPVAVDLKEVFYLA
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLZ16_COCLU
Sequence: MSTTTTTLHTTTGTVYVADGTTDGKIGYYNHTDDSTNVIRKPIPIQVEDARTLSKSPTTKEEGYQLVDFHTKLPEGHFLDSKSPENKKVIEQVYFDECRRLVQEVTGAAEAYPYVYRVRNQEQNAKASNKSNFHTDFVPVVHVDRDDITAPQRLRASLGAEKAEMLLSKYKSYGSINVWRPVKNVVQKWPLMLVDHKSIENWDYSTHMFTLHSSNDERVATRGAKDHETILTHDKRYRYIYASDMTPDEAWLFFAFHSDPALGIPHGAFWDDSTKEEALTRCSIEVRIWVFFD
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS) (PubMed:28605916).  SQS1 is composed of a 2,8-dioxobicyclic[3. 2. 1]octane-3,4,5-tricarboxyclic acid core that is connected to two lipophilic polyketide arms (PubMed:28605916).  These initial steps feature the priming of an unusual benzoic acid starter unit onto the highly reducing polyketide synthase clz14, followed by oxaloacetate extension and product release to generate a tricarboxylic acid containing product (PubMed:28605916).  The phenylalanine ammonia lyase (PAL) clz10 and the acyl-CoA ligase clz12 are involved in transforming phenylalanine into benzoyl-CoA (PubMed:28605916).  The citrate synthase-like protein clz17 is involved in connecting the C-alpha-carbons of the hexaketide chain and oxaloacetate to afford the tricarboxylic acid unit (PubMed:28605916).  The potential hydrolytic enzymes, clz11 and clz13, are in close proximity to pks2 and may participate in product release (PubMed:28605916).  On the other side, the tetraketide arm is synthesized by a the squalestatin tetraketide synthase clz2 and enzymatically esterified to the core in the last biosynthetic step, by the acetyltransferase clz6 (By similarity).  The biosynthesis of the tetraketide must involve 3 rounds of chain extension (By similarity).  After the first and second rounds methyl-transfer occurs, and in all rounds of extension the ketoreductase and dehydratase are active (By similarity).  The enoyl reductase and C-MeT of clz2 are not active in the final round of extension (By similarity).  The acetyltransferase clz6 appears to have a broad substrate selectivity for its acyl CoA substrate, allowing the in vitro synthesis of novel squalestatins (By similarity).  The biosynthesis of SQS1 requires several oxidative steps likely performed by oxidoreductases clz3, clz15 and clz16 (Probable).  Finally, in support of the identification of the cluster as being responsible for SQS1 production, the cluster contains a gene encoding a putative squalene synthase (SS) clz20, suggesting a likely mechanism for self-resistance (Probable).
What are the official names of this protein?
Oxidoreductase clz16, Squalestatin S1 biosynthesis cluster protein clz16, Zaragozic acid A biosynthesis cluster protein 16.
What is the protein family that this protein belongs to?
Belongs to the asaB hydroxylase/desaturase family.
Protein: GPA_LEIDO
Sequence: MSRSTHASGHMETVQVISALTDYIDQSKFAEIHSKLKRGDGPGESGKSTIFQIIGIAGRPSLSKSSEFSLKATEITLLSTCYHMLPDDYFGLLPLSSASVNATSTLLSTATISRPSFSVQTSSSTFANFLMSGTSWRSRRQRLKIVDVGGQRSQRRKLTAELAQDIKALWADPGIQNTFQRSSEFQLNDSAAYYFDSIDRISQPLYLPSENDVLRSRTKTTGIIETVFEIQNSTFRMVDVGGQRELANAHTELNNPIVQREEFVKQLRNRDKGDDESMEIDEGFVAALEHALPPTGGWGLGIDRLVMFLTSQSNIKEVLLFPAMKPEGKNAISYPPGTRCSMVRVFPCCSSTLTFSFCFFFSPFFMTVILFVEAAAMKVRGGYSGTCLSVSPRFSNGGDVLWRTSETKRDKYNEKRHAAVKTPAQRSFLESGWNTASDVKCCSIRRFPYLPLPLSSSPFRFPPP
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Putative guanine nucleotide-binding protein subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
Protein: ISPD_PECAS
Sequence: MQISSLSPPEIVAVLPAAGNGSRMQNDRPKQYLTIGNDATGHKTILEHTIDALLRHSRVQRVVVVISPDDTFFHTLAIANDPRICAVTGGKLRADSVLAGLAVVADSAWALVHDAARPCLHQDDLTRLLAIVEQSDVGGILAAPVRDTMKRSTDGFIDRTVERNDLWHALTPQLFPAALLKQCLQRALQDGVAVTDEASALEYCGYRPQIISGRSDNIKVTRPEDLALAEFYLTRLQ
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: POLS_EEEV8
Sequence: MFPYPTLNYPPMAPVNPMAYRDPNPPRRRWRPFRPPLAAQIEDLRRSIANLTFKQRAPNPPAGPPAKRKKPAPKPKPAAPKKKRQPPPAKKQKRKQKPGKRQRMCMKLESDKTFPIMLNGQVNGYACVVGGRVFKPLHVEGKIDNEQLAAIKLKKASIYDLEYGDVPQCMKSDTLQYTSEKPPGFYNWHHGAVQYENNRFTVPRGVGGKGDSGRPILDNRGRVVAIVLGGANEGSRTALSVVTWNQKGVTVKDTPEGSEPWSLTTVMCVLANITFPCDQPPCMPCCYEKNPHETLSMLEQNYDSQAYDLLLDAAVKCNGRRTRRDLETHFTQYKLARPYIADCSNCGHGRCDSPIAIEDIRGDAHAGYIRIQTSAMFGLKSDGVDLAYMSFMNGKTLKAIKIEHLYARTSAPCSLVSYHGYYILAQCPPGDTVTVGFQDGAIKHMCTIAHKVEFKPVGREKYRHPPEHGVELPCTKYTHKRADQGHYVEMHQPGLVADHSLLSMSSTKVKITVPSGSQVKYYCKCPDVKEGTTGSDYTTACTDLKQCRAYLIDNKKWVYNSGKLPRGEGETFKGKLHVPFVPVTSKCTATLAPEPLVEHKHRSLVLHLHPEHPTLLTTRALGSNARPTRQWIEQPTTVNFTVTGEGFEYTWGNHPPKRVWAQESGEGNPHGWPHEIVIYYYNRYPMTTVIGLCTCVAIIMVSCVTSVWLLCRTRNLCITPYRLAPNAQVPILLAVLCCVKPTRADDTLQVLNYLWNNNQNFFWMQTLIPLAALIVCMRMLRCLLCCGPAFLLVCGALGAAAYEHAAVMPNKVGIPYKALVERPGYAPVHLQIQLVTTKIIPSANLEYITCKYKTKVPSPVVKCCGSTQCSAKSLPDYQCQVFTGVYPFMWGGAYCFCDTENTQMSEVYIERAEECSVDQAKAYKVHTGTVQAVVNITYGSVSWRSADVYVNGETPAKIGDAKLTIGPLSSAWSPFDSKVVVYGHEVYNYDFPEYGTGKAGSFGDLQSRTLTSNDLYANTNLKLQRPQPGVVHTPYTQAPSGFERWKKDRGAPLNDIAPFGCTIALDPLRAENCAVGNIPLSIDIPDAAFTRIAETPTVSDLECKVTECTYASDFGGIATISYKASKAGNCPIHSPSGIAVIKENDVTLADSGAFTFHFSTASIHPAFKMQVCTSVVTCKGDCKPPKDHIVDYPAQHTETYTSAVSATAWSWLKVLVGSTSAFIVLGLIATAVVALVLFTHRH
What is the function of this protein?
Class II viral fusion protein.  Fusion activity is inactive as long as E1 is bound to E2 in mature virion.  After virus attachment to target cell and endocytosis, acidification of the endosome would induce dissociation of E1/E2 heterodimer and concomitant trimerization of the E1 subunits.  This E1 trimer is fusion active, and promotes release of viral nucleocapsid in cytoplasm after endosome and viral membrane fusion.  Efficient fusion requires the presence of cholesterol and sphingolipid in the target membrane.  Fusion is optimal at levels of about 1 molecule of cholesterol per 2 molecules of phospholipids, and is specific for sterols containing a 3-beta-hydroxyl group.
What are the official names of this protein?
Structural polyprotein, p130.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm. Host cell membrane. Host nucleus. SUBCELLULAR LOCATION: [Spike glycoprotein E2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [6K protein]: Host cell membrane; Multi-pass membrane protein. Virion membrane; Multi- pass membrane protein. SUBCELLULAR LOCATION: [Spike glycoprotein E1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: ESYT3_XENTR
Sequence: MAQGDPGGQTPQAPQGTDKKPDEPKATEKPQGAGPQPRDPPGGEKGLRDPPGGEKGPRDPGQGGAGEALAEALYGLGRPVLRAVLYLFPVYLCGRFGLSPTWLLFGLFLWMFWTRNKKFKLARIQAAWDLHENEKLGVTRGLYLQQLPAWVNFPDVERVEWLNKVVGQMWPYIGMYVEKMFQDKVEPLVRSSSAHLKAFTFTKVHLGEKFPRINGVKSYTKNVDKREVILDLQLSYNGDVEINVEVKKMCKAGVKGVQLHGTLRVILAPLLPDLPFVGAVTMFFIQRPHLDINWTGLTNVLEIPGVSDFSDSMIVDMIASHLVLPNRFTVPLSSQVQAAQLRFPLPHGVLRLHLIEAEDLIPKDNYLKGIIRGKSDPYAVLRIGNQNFKSRTIKENLNPKWGEMYEFVVHEVPGQDLEVDLYDEDPDKDDFLGSLVIGLEGVMQDRVVDEWFPLSDVPSGSVHLRLEWLSLLPKSEKLSEAKGGISTAMLIVYLDSASALPRNHFEYSSSEYTTRKQRHMTYTKTDKDPNSYVLMSVGKKSVKSKTCTGSTEPVWGQAFAFFIQDVHMQHLHLEVKDSERQCALGMLDLPLHRLLGNEELTADQRFPLANSGPNSTIKMKIVLRVLHVEAPEPESIYTGINSLKQGPVSIKRAQSQQHKSHGKSHQAHHQAHQTQQNHTVQQPKAERKESISTTSQQANTSSSNPAPNQNPNSTGAVPESHTPSLKPLERIAPSLLSLNSIGSSVFDPNDKRWPSEMTGEVEVSVRYASLRRCLVVLINSCRNLIQCSSNGADPYVRIYLLPDRKWSGRKKTSVKRKTLNPQYNERFEFLVSQEEAKKRMLDVAVKNNRGFGSHERKELGKVLVDLSCDDLVKGFTKWFELTPTGLPTS
What is the function of this protein?
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.  Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).
What are the official names of this protein?
Extended synaptotagmin-3, E-Syt3.
What is the protein family that this protein belongs to?
Belongs to the extended synaptotagmin family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Recruited to the cell membrane via the third C2 domain (By similarity).
Protein: RLUF_ECO57
Sequence: MLPDSSVRLNKYISESGICSRREADRYIEQGNVFLNGKRATIGDQVKPGDVVKVNGQLIEPREAEDLVLIALNKPVGIVSTTEDGERDNIVDFVNHSKRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPITDEFIRGMGAGVPILGTVTKKCKVKKEAPFVFRITLVQGLNRQIRRMCEHFGYEVKKLERTRIMNVSLSGIPLGEWRDLTDDELIDLFKLIENSSSEAKPKAKAKPKTAGIKRPVVKMEKTAEKGGRPASNGKRFTSPGRKKKGR
What is the function of this protein?
Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-2604 in 23S ribosomal RNA and from uracil-35 in the anticodon of tRNA(Tyr).
What are the official names of this protein?
Dual-specificity RNA pseudouridine synthase RluF, 23S rRNA pseudouridine(2604) synthase, Ribosomal large subunit pseudouridine synthase F, rRNA pseudouridylate synthase F, rRNA-uridine isomerase F, tRNA(Tyr) pseudouridine(35) synthase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RsuA family.