PharMolix/UniProtQA huggingface dataset:
Protein: BPT_GLUDA
Sequence: MTYTSPRRPQLFYTTAPMPCPYVAGRMERKVVTDIGGPDAERLHNRLSRAGFRRSHTIAYAPVCPSCSACVPIRVPVASFSPDRTQRRTLRRNATIEGFEVPAHATTEQFTLFQRYQFARHAEGDMAAMNFYDYRAMIEDTPIDTMMIEFRTPEDRLVCVSLIDRLDDGLSAVYSFFDPTMDARSLGSYAIMHLIAHTRRLGLPYLYLGYWIRDSAKMAYKARFQPAEILFHGAWTPLDRDRLPEEGDRGPARFPASLTE
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSZ_WOLSP
Sequence: MSIDLSLPELPILHPRITVVGVGGAGGNAVNNMIQSNLQGVNFVVANTDAQALEKSLCDKKIQLGINLTKGLGAGALPDVGKGAAEESIDEIMEHIKDSHMLFITAGMGGGTGTGAAPVIAKAAREARAAVKDRAPKEKKILTVGVVTKPFGFEGVRRMPIAELGLEELQKYVDTLIVIPNQNLFRIANEKTTFSDAFKLADNVLHIGIRGVTDLMVMPGLINLDFADIETVMSEMGKAMIGTGEAEGEDRAISAAEAAISNPLLDNVSMKGAQGILINITGGGDMTLFEVDAAANRVREEVDENANIIFGATFDQAMEGRVRVSVLATGIDGRNNKSETSPISQSEDSEKEKFKWPYSQSESTQDKTLETKPAEQVSEGAKWGSNIYDIPAYLRRKK
What is the function of this protein?
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.  The regulation of the ring assembly controls the timing and the location of cell division.  One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells.  Binds GTP and shows GTPase activity.
What are the official names of this protein?
Cell division protein FtsZ.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Protein: AROB_NITOC
Sequence: MITVQVDLQERSYPIYIGSGLLKQNSLLAKHIVGSEVMVVTNETVAPLYLDTLLKGLKDYRCAEIILPDGEQHKTLAVLQQIFDDLLKVPFSRHCTVIALGGGVIGDMAGFAAACYQRGVAYIQVPTTLLAQVDSSVGGKTAVNHPLGKNMIGAFYQPRCVLADTDTLDTLDERQLRAGLAEVIKYGLIRDIDFFTWLEEHASEVLAREPSALIHAIERSCRNKAEIVAADERESGVRAILNLGHTFGHAIETGLGYGAWLHGEAVAAGMAMAADLSQRLGWLSATEVGRVLNLLERAGLPRHSPEAIHKARFLELMAVDKKVIDGCLRLVLLRQLGQAVVTDGFDSDLLEATIDKATV
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KA121_TITSE
Sequence: MQVFYGLLLMFILCSTIHLSEQWCSTCLDLACGASRECYDPCFKAFGRAHGKCMNNKCRCYT
What is the function of this protein?
Potently blocks Kv1. 3/KCNA3, Kv1. 2/KCNA2, and Shaker potassium channels (PubMed:24590385) and inhibits high conductance calcium-activated potassium channels (PubMed:10082164).  Is potent against Kv1. 3/KCNN3 (IC(50)=0. 55 nM) and Kv1. 2/KCNN2 (IC(50)=6. 19 nM) (PubMed:24590385).  It also stimulates the release of NO, IL-6 and TNF-alpha in J774. 1 cells and presents a pro-inflammatory activity in mice (PubMed:21549737, PubMed:23085190).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 12.1, Butantoxin, BuTX, Tityustoxin-6, Ts6, TsTX-IV.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 12 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RNS10_PIG
Sequence: MKLTLVQFFFMMLLLLLGLGVGLGLGLQMAAAVLEESDQLLSEFQSSDSQDKTQATKKGAGTRTMETLLLSDNVVMQPEETILSEDEVGGNKMLRAQAFSQSYPNYLRSDLMDRECNTLMAKKMKPYNHTCISQYIFIHEEPDEIKAVCKSPPVACELKGGKCHKSARPFDLTFCKLSKPGQVTPHCNYVTFLLEKHILISCNDMKVQVMSGS
What is the function of this protein?
Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility.  May be involved in sperm adhesion to the egg zona pellucida (By similarity).  Does not have ribonuclease activity.
What are the official names of this protein?
Inactive ribonuclease-like protein 10, Protein Train A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
Protein: RS2_RHOOB
Sequence: MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTYIDKAYEFVKETVAHGGTVLFVGTKKQAQESIAAEATRVGMPYVNQRWLGGMLTNFTTVHKRLLRLKELEAMEQTGGFEGRTKKEILMLTREMTKLDRTLGGIRDMAKVPSAVWVVDTNKEHLAVAEARKLNIPVIAILDTNCDPDLVDYPIPGNDDAIRSAALLTKVVASAVAEGVQARAGLSSDKDAKPEAGAGEPLAEWEQELLSQAAPAAEAAPAAEAQAAPAAEAPAAEAPSTEA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SYK_PSEPW
Sequence: MSDLKTESQDLQQEENTLIALRKEKLAAEREKGQAFPNDFRRDSYCNDLQKQYVDKTKEELEAAAIPVKVAGRIMLNRGSFMVIQDMTGRIQVYVNRKTLPEETLAAVKTWDLGDIIAAEGTLARSGKGDLYVEMTNVRLLTKSLRPLPDKHHGLTDTEQRYRQRYVDLMVNEETRHTFRVRSQVISHIRKFLIDRDFLEVETPMLQTIPGGAAAKPFETHHNALDMAMFLRIAPELYLKRLVVGGFEKVFEINRNFRNEGVSTRHNPEFTMLEFYQAYADYRDNMDLTEELFRELAQLVLGSTDVPYGDKVFHFGEPFVRLSVFDSILKYNPELTAADLQDVDRARDIAKKAGAKVLGHEGLGKLQVMIFEELVEHKLEQPHFITEYPFEVSPLARRNDDNPAVTDRFELFIGGREIANAYSELNDAEDQAERFLAQVAEKDAGDDEAMHYDADFVRALEYGMPPTAGEGIGIDRLVMLLTNSPSIRDVILFPHMRPQA
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOLIN_BPKMV
Sequence: MMLDTATEAGKGTLAVTGVGIAVYSPYEIASLCAAVLTALYVGAQLITLLPKMLDSIAELRRRFKK
What is the function of this protein?
Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of nanometer-scale pores (pinholes) causing host cell membrane depolarization and endolysin refolding and release into the periplasmic space (PubMed:21687532).  Once the pinholin has permeabilized the host cell membrane, the SAR-endolysin is released into the periplasm and breaks down the peptidoglycan layer (PubMed:21687532).  Determines the precise timing of host cell lysis.  Participates with the SAR-endolysin and the U-spanin protein in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell (PubMed:21687532).
What are the official names of this protein?
Holin, KMV44, Pinholin.
What are the subcellular locations of this protein?
Host cell inner membrane; Single-pass type II membrane protein.
Protein: TRNL_CANAL
Sequence: MKDSQSDIIELCNKLNEATKLKRNGKSIKLTNFVSNTQIKLDSWKFLEWDYGKPSVQLPIQARGLFTLNNDTIAVRGYDKFFNVEEKPFTKETNLKTSTHGPYEVTLKENGCIIFISGLSTGDIVVCSKHSTGDRIDDNESDKTTTATATATAPTRNHAKQGEFELLQQFDGDQQKVKQLAHYLYENNLTVVAELCDDEFEEHVLPYPKDKSGLYVHGLNYNTITFKTLPMDQVLQFAKEWGFKYVSYLTYDNADELFKFLHKCSETGTYNGREIEGFVIRCHRQSHTNGDTDGDCFFFKYKFEQPYLLYRQFREVTKQLLNGTPINSIKIKKNKPITKKYLQFVEKLFEQEPEIARNFENGFDIIKVRQLFLQSLNETNGMNLLSIDSELSDQLKNLALANGNEGLSTTTKYIFVPIATIGCGKTTVFNTLNNLFPQWTHIQNDNISKKAKLKICDLTLLALEDDDQSVVLFDRNNSASRERRQIFTTIDQKRDEHLDDTVDLKYIAINFIPEDLSEEELWDITYNRVIQRGDNHQSIKSQSDENLVESVMKGFIQRYQPINTSRSPDDQFDHVIHLKLSKDENSSKSSLENVRIIIDDLVQNFPDLIKEKPADELINECFQKALDYKPTFVKNMTANTIKKDPTYYGIAMHYSSILENLEIVSHNEHFQNIKSHIQTEFHVTLGHIASSKQDKAGRVKWKKLVKTLGKGDPNKPKSALKFFADVKLLQIVINTDKLACIKVEILKIYDTNDVLQSEIEPINKQLHITIGCIPPATAVESNITLEELYDNPDEQELKPDGTYKCGDDTLHVFNFDNPDLKLFSQQLFVAYQ
What is the function of this protein?
One of the two proteins required for the splicing of precursor tRNA molecules containing introns.  The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction.
What are the official names of this protein?
tRNA ligase.
What is the protein family that this protein belongs to?
Belongs to the TRL1 family.
Protein: CAF1B_ARATH
Sequence: MSQAPNPEEEDDTIEIREVWNHNLEQEMALIEQSIDDFPYVAMDTEFPGIVCKTVTANPNPNPYSIHYEYNYDTLKANVNMLKLIQLGLTLSDEKGNLPTCGTNKQCIWQFNFREFNVISDMFALDSIELLRKSAIDLEKNNECGVDAKRFAELLMGSGVVLNDKIHWVTFHCGYDFGYLLKLLSGKELPEEISDFFDQMEKFFPVVYDIKYLMGFCTNLYGGLEKIAELLGVKRVGISHQAGSDSLLTLRTFIKMKEFFFTGSLLKYSGFLFGLDNPRLLTGSKN
What is the function of this protein?
Ubiquitous transcription factor required for a diverse set of processes.  It is a component of the CCR4 complex involved in the control of gene expression (By similarity).
What are the official names of this protein?
Probable CCR4-associated factor 1 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the CAF1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: PVK21_PSEBJ
Sequence: GSSSGLISMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2.1, Pea-PVK-2-like peptide, Periviscerokinin-3, PseBi-PVK-3.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL5_LAWIP
Sequence: MTRLEKFYQEKVVPALQKEFLYKSIMQVPTIEKISLNIGLGVASQSNKIMEEAISELSLIAGQKAVITRAKKSIASFKLREGMPIGCRVTLRKERMWDFLDKLMNFALPRVRDFRGVSENGFDGHGNFTLGIKEHSIFPELEIDRIENTKGMNITIVTSAVLDSEGKVLLDLLGMPFKK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: BSAA_STAES
Sequence: MESIYDFVVQKNNGESYKLEQYKGDVMLIVNTASECGFTPQFEGLQKLYDEYKDQRFIILGFPCNQFGGQEPGSGEEAAQNCKINYGVTFPIHEKVDVKGDNQHPLFHFLTNAAKGMINEKIKWNFTKFLIDREGNVIKRFSPQKKPEQIKTEIEKLL
What are the official names of this protein?
Glutathione peroxidase homolog BsaA.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
Protein: SYT_CALMQ
Sequence: MRLLLIHARSFSFEVRDKAVENPEPLTEELKRGSADNTLVVFTTVEENDNDSPSFLERVADDVLDVAGKVKASSVFLYPYAHLSPNLAPPPKAITILNALYETLKGKASIPVYRAPFGWYKAFNISCLGHPLSELSRTITPQESAPQRKPYTRDYYVIVSPDGSIHDPASYSFSERDADLKVLVDKEVFKRELEGKEQPRYIDYCLKFGFEWEPLSDVGHMRYGPYATVMLELLDDYSYQVAKSLGIPVFKVKGTNMFRLSDKAISEHAGLFGERMYITESDEELVMRYAACFQQFAMIKDWVLSYRNLPLGMLEIADSYRYEQPGETVLCFRLRRFYMPDLHIFVKDLKEAMDVGLRLHAKIFEEIRRIGRDYVSLYNVSKEFFDQNKDYLVELARREGKPILVRVLEGAKYYWVLNVEYHIIDELKRPREIATFQFDIGNAQRFGIKYRDEGNNIKYPVIIHTAILGSIERFIFALLDTAAINEANGKVPALPTWITPVQVRVIPVSSGYNEGAIELARRIEEAGFRVEVDDRDETVGRKIRDAETLWVPYIVVFGEREAKTGSLSVRVRGVGQVSMSIEELLNRLNEETKGYPRKPLTAPMLLSIRPPLP
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREB1_HUMAN
Sequence: MGNSYAGQLKTTRFEEVLHNSIEASLRSNNLVPRPIFSQLYLEAEQQLAALEGGSRVDNEEEEEEGEGGLETNGPPNPFQLHPLPEGCCTTDGFCQAGKDLRLVSISNEPMDVPAGFLLVGVKSPSLPDHLLVCAVDKRFLPDDNGHNALLGFSGNCVGCGKKGFCYFTEFSNHINLKLTTQPKKQKHLKYYLVRNAQGTLTKGPLICWKGSEFRSRQIPASTCSSSLFPALESTAAFPSEPVPGTNPSILMGAQQAGPASDHPSLNAAMGPAVFNGKDSPKCQQLAKNNLLALPRPSALGILSNSGPPKKRHKGWSPESPSAPDGGCPQGGGNRAKYESAGMSCVPQVGLVGPASVTFPVVASGEPVSVPDNLLKICKAKPVIFKGHGNFPYLCGNLNDVVVSPLLYTCYQNSQSVSRAYEQYGASAIQPISEEMQLLLTVYYLVQLAADQVPLMEDLEQIFLRSWRESHLTEIRQYQQAPPQPFPPAPSAAAPVTSAQLPWLASLAASSCNDSVHVIECAYSLAEGLSEMFRLLVEGKLAKTNYVVIICACRSAAIDSCIAVTGKYQARILSESLLTPAEYQKEVNYELVTGKVDSLGAFFSTLCPEGDIDILLDKFHQENQGHISSSLAASSVTKAASLDVSGTPVCTSYNLEPHSIRPFQLAVAQKLLSHVCSIADSSTQNLDLGSFEKVDFLICIPPSEVTYQQTLLHVWHSGVLLELGLKKEHMTKQRVEQYVLKLDTEAQTKFKAFLQNSFQNPHTLFVLIHDHAHWDLVSSTVHNLYSQSDPSVGLVDRLLNCREVKEAPNIVTLHVTSFPYALQTQHTLISPYNEIHWPASCSNGVDLYHENKKYFGLSEFIESTLSGHSLPLLRYDSSFEAMVTALGKRFPRLHSAVIRTFVLVQHYAAALMAVSGLPQMKNYTSVETLEITQNLLNSPKQCPCGHGLMVLLRVPCSPLAVVAYERLAHVRARLALEEHFEIILGSPSSGVTVGKHFVKQLRMWQKIEDVEWRPQTYLELEGLPCILIFSGMDPHGESLPRSLRYCDLRLINSSCLVRTALEQELGLAAYFVSNEVPLEKGARNEALESDAEKLSSTDNEDEELGTEGSTSEKRSPMKRERSRSHDSASSSLSSKASGSALGGESSAQPTALPQGEHARSPQPRGPAEEGRAPGEKQRPRASQGPPSAISRHSPGPTPQPDCSLRTGQRSVQVSVTSSCSQLSSSSGSSSSSVAPAAGTWVLQASQCSLTKACRQPPIVFLPKLVYDMVVSTDSSGLPKAASLLPSPSVMWASSFRPLLSKTMTSTEQSLYYRQWTVPRPSHMDYGNRAEGRVDGFHPRRLLLSGPPQIGKTGAYLQFLSVLSRMLVRLTEVDVYDEEEININLREESDWHYLQLSDPWPDLELFKKLPFDYIIHDPKYEDASLICSHYQGIKSEDRGMSRKPEDLYVRRQTARMRLSKYAAYNTYHHCEQCHQYMGFHPRYQLYESTLHAFAFSYSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVTDKSHEYIKSPTFTPTTGRHEHGLFNLYHAMDGASHLHVLVVKEYEMAIYKKYWPNHIMLVLPSIFNSAGVGAAHFLIKELSYHNLELERNRQEELGIKPQDIWPFIVISDDSCVMWNVVDVNSAGERSREFSWSERNVSLKHIMQHIEAAPDIMHYALLGLRKWSSKTRASEVQEPFSRCHVHNFIILNVDLTQNVQYNQNRFLCDDVDFNLRVHSAGLLLCRFNRFSVMKKQIVVGGHRSFHITSKVSDNSAAVVPAQYICAPDSKHTFLAAPAQLLLEKFLQHHSHLFFPLSLKNHDHPVLSVDCYLNLGSQISVCYVSSRPHSLNISCSDLLFSGLLLYLCDSFVGASFLKKFHFLKGATLCVICQDRSSLRQTVVRLELEDEWQFRLRDEFQTANAREDRPLFFLTGRHI
What is the function of this protein?
May play a role in estrogen-stimulated cell proliferation.  Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
What are the official names of this protein?
Protein GREB1, Gene regulated in breast cancer 1 protein.
What is the protein family that this protein belongs to?
Belongs to the GREB1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GLR24_ARATH
Sequence: MKRHLNDVVLVFLVFIFGVKLGKGQNTTIQVINVGVVTDVGTTASNLSLLAINMSLSDFYSSRPESRTRLLLNFADSRDDVVGAAAAALDLIKNKEVKAILGPRTTMQASFVIEVGQKSQVPIISFSATSPFLDSGRSPYFFRSTYDDSSQVQAISEIIKVFGWREVVPVYENNAFGEGIMPGLTDALQAINIRIPYRTVISPNATDDEISVDLLKLMTKPTRVFVVHMNRFLASRVFSKARETGLMKQGYAWILTNGVIDHLVLMNGTDIEAMQGVIGIRTHFPISEELQTFRSRLAKAFPVSELNIYGLRAYDATTALAMAVEEAGTTNLTFSKMDGRNISDLEALSVSEYGPKLIRSLSQIQFKGLSGDYHFVDGQLHASVFEIVNVIDGGGILVGFWTQDKGLVKDLSPSSGTTRTFSSWKNHLNPILWPGITLTVPKGWEIPTNGKELQIGVPVGTFPQFVKVTTDPLTHETIVTGFCIDFFEAVIQAMPYDVSHRFIPFGDDDGKTNVFDAVVGDTTILANRSSYVDFTLPYTTSGVGMVVPLKDNVARSSLIFFKPLTPGLWGMTLGSFFVVGFVVWILEHRVNSEFTGPPQYQISTMFWFAFSIMVFAPRERVMSFTARVVVITWYFIVLVLTQSYTASLSSLLTTQQLNPTETSIKNVLAKGGPVAYQRDSFVLGKLRESGFPESRLVPFTSPEKCEELLNKGPSKGGVSAAFMEVPYVRVFLGQYCKKYKMVEVPFDVDGFGFVFPIGSPLVADVSRAILKVAESNKATQLETAWFKNIDKTCPDPMNNPDPNPTVSFRKLSLDSFLLLFVAAATVCTLALLKFVICFLIQNRIILNDEFYRGKRMKEMWLKFMESDGESYISRVRSTCPQVLIQPREEDIDPING
What is the function of this protein?
Glutamate-gated receptor that probably acts as non-selective cation channel.  May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
What are the official names of this protein?
Glutamate receptor 2.4, Ligand-gated ion channel 2.4.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AMRP_HUMAN
Sequence: MAPRRVRSFLRGLPALLLLLLFLGPWPAASHGGKYSREKNQPKPSPKRESGEEFRMEKLNQLWEKAQRLHLPPVRLAELHADLKIQERDELAWKKLKLDGLDEDGEKEARLIRNLNVILAKYGLDGKKDARQVTSNSLSGTQEDGLDDPRLEKLWHKAKTSGKFSGEELDKLWREFLHHKEKVHEYNVLLETLSRTEEIHENVISPSDLSDIKGSVLHSRHTELKEKLRSINQGLDRLRRVSHQGYSTEAEFEEPRVIDLWDLAQSANLTDKELEAFREELKHFEAKIEKHNHYQKQLEIAHEKLRHAESVGDGERVSRSREKHALLEGRTKELGYTVKKHLQDLSGRISRARHNEL
What is the function of this protein?
Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.
What are the official names of this protein?
Alpha-2-macroglobulin receptor-associated protein, Alpha-2-MRAP, Low density lipoprotein receptor-related protein-associated protein 1, RAP.
What is the protein family that this protein belongs to?
Belongs to the alpha-2-MRAP family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment lumen. Golgi apparatus, cis- Golgi network. Golgi apparatus lumen. Endosome lumen. Cell surface. Note=May be associated with receptors at the cell surface.
Protein: PTH_EHRRG
Sequence: MLHLLVGLGNPGKEYELTRHNVGFMIIDAIMHHFLFPDFKKKHNALISSGSIQSYKVILAKPYTFMNNSGAPISSIVKLYKIPLDNIIVFHDETDIDFCTIRIKKGGGNAGHNGLKSIDTLLGRDYWRIRFGIGHPSNGYDLSYHVLSQFNNLNAVNNTISNIIEHISLLFENDKSIFKNKVKDLIKYTDISS
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_BACCZ
Sequence: MIDVNNFEYMKIGLASPDKIRSWSYGEVKKPETINYRTLKPEKDGLFCERIFGPQKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVSHIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTESGDTPLDKKQLLSEKEYRAYRDRYGSTFQAAMGAEAIKKLLQDIDLDKEVDFLKEELKTAQGQRRTRAIKRLEVLEAFRNSGNEPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPNLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIERVQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADFDGDQMAVHVPLSSEAQAEARLLMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLEREGAIGEGMVFKDANEALLAYQNGYVHLHTRVAVAASAVNNATFTEEQKSMLLLTTVGKLIFNEILPESFPYINEPTNSNLEKETPAKYFVEKGANIKEIIASREEVAPFSKKILGNIIAEVFKRFKITETSRMLDRMKNLGFKYSTKAGITVGVSDILVLGEKDEILHEAQAKVDNVIKQFRRGLITEEERYDRVISIWSNAKDVIQGKLMKSLNKRNPIFMMSDSGARGNASNFTQLAGMRGLMANPSGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIVREDDCGTDRGLLIGAIKEGNEVIESLYDRLVGRFARKTVKHPETGEVLVAENQLITEDIAHIVENSGVETVNIRSAFTCNTRHGVCKKCYGRNLATGTDVEVGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQEIFEARNPKGQAVISEIDGVIAAINDVKDRQEVVVQGEVEARTYAIPYGARLKVIPGQKISHGKELTEGSIDPKELLKVTDITAVQEYLLREVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVSDAGETDVLPGTLLDIHQFTDANAKVLLQGKQPATARPVLLGITKASLETDSFLSAASFQETTRVLTDAAIKGKRDELLGLKENVIIGKLVPAGTGMNRYRKVDLVKTTQDDMNVENDEVYVEQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: Y1226_AGARV
Sequence: MKIILSPAKKMIVDTDNLVPVELPVYIDKTAEVLNWIKSKSKEELKAIWKCNDKIAEQNFNRLENMDLYNRLTPAVLAYEGIAFQYMAPSVFENSQFEYVQNHLRILSAFYGVLKPMDGVTPYRLEMQAKVEIGDAKNLYEYWNDMLYRSVIDESRIIINLASKEYSKCIEKYLTPKDKYITISFCEQAGNKLVTKGTYAKMARGEMVRFMAENDIENPDDIKKFDRLGYIFRSDLSSDSKYVFERKIA
What are the official names of this protein?
UPF0246 protein EUBREC_1226.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: NADE_SHEPA
Sequence: MKGQILREMKVLNAIDPGFEVQRRVAFIKSKLKQSSTSTLVLGISGGVDSSLAGRLCQLAVDELNSDASGNHYQFIAVRLPYDVQKDEDEAQLACQFIQPSKQVTVNVKQGVDGVHCETLAAVEAAGIALPEADKIDFVKGNVKARMRMVAQYEIAGLVAGLVVGTDHSAENITGFYTKWGDGACDLAPLFGLNKRQVRQLAAFLGAPDKLVIKAPTADLEENKPQLEDEVALGLTYEQIDDFLEGKEVSEFVNDKLVGIYRATQHKREPIPTIYD
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: LDH1_LACJO
Sequence: MSEEKIHKIILVGDGAVGSTYAFSLVQQGIAQELGIVDIVKERTQGDAIDLADATPWIAPKTIYSAEYSDAKDADLVVISAGAPQKPGETRLDLVNKNLKILSSIVEPIVESGFNGIFLVAANPVDILTHATWRMSGFPKDRVIGSGTSLDTGRLQKVIGEMEHVDPRSVNAYMLGEHGDTEFPVWSYNNVGGVKVSDWVKAHPEVGENKLEAIHKEVADMAYDIINKKGATFYGIGTALAFITKAILNNEHRVLPLSVPMDGEYGLHDIHIGTPAVVGRHGLEQVIEMPLNADEQAKMEASAKQLKEVMDKAFKETGVKVRQ
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase 1, L-LDH 1.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDA_RAT
Sequence: MNGDTRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPDLRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTASVPNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTNLGVNQAGFTLHSAIYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGEVAYHDYHGILVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGGPDNLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQIGEQEFEALMRMLDNLGYRTGYPYRYPALRERSKKYSDVEVPASVTGHSFASDGDSGTCSPLRHSFQKQQREKTRWLNSGRGDDASEEGQNGSSPKSKTKWTKEDGHRTSTSAVPNLFVPLNTNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVMMDRSLVQGELVTASKAIIEKEYQPHVIVSTTGPNPFNTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEGGLPQEPTSRDGSDATTSKPTPPDLSPDEPSEALAFPTVAEEAHASPDTTQPLAEADPEPASASAPGAEEVASPATEEGSPMDPGSDGSPGKSPSKKKKKFRTPSFLKKSKKKSDS
What is the function of this protein?
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network.  Binds to calmodulin.
What are the official names of this protein?
Alpha-adducin, Erythrocyte adducin subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. Adducin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CS111_KLULA
Sequence: MGKTNKNRIKTGISYRSLHLLISANETVKEKREAEQLPALDNDTQCLMSTGKVHILNADYSRYGVSVYDKLYGYSSSAASTIEEEDKGSGDGFKKRYMSLMQGSSQWKSRKLKQKKNAPKASAKAKAFLVRLHSEKRRHEVDFADINCLPEEIICRIIANLNDADSQRNCLLVSQEWSECAKRIIYKDVKFTSTYRVGQFVTTLRENPQYGKYVESLDLSQLKNGFINDESSTLENDVSQSSYGFEPPDIAYAGWRDWRYRKNSLYGSEMLSSIHRSRTRRSSDASSMNSSVFSHNYNRTRSSSVTSLVSRSTQTAAGSKNVVKRIRKLFSNSFRGKGQQKTHLHQNNGSGLSTLELKDEQFAAGTDSCSLRRSHLPFTNKFFLKYAHLRDLPLGYIIHLLTLCVNLKSINLSNLSLSPDFEIEELEYKRNGYVSFFPEETEEENLNGLNTFNGDRELTPKFFSDSDKPYHYYKDTQYESIIWKLDSSRDNNMFTNRRRSRKKFQLKILTNDDLCEAILSLKHMKHLNVGNVVWLMQRDMKRLIVHSMESCIIEDRCLDKIYMNFEGSGLQTNLPLAGQGLLKAMVLLQVITDMTNNCSDDQILEWFELRWIPTFRRVSQPADLVYLARACDQLHYVIQSEESPTYTRVGEVLITESHTGHYKYEISRNVNNVYLTIQIENGKPDTITDVKLKECSDRLLERVSNLRKNQLLQHTGENFFSTAGLA
What is the function of this protein?
F-box protein probably involved in ubiquitin conjugation pathway.
What are the official names of this protein?
F-box protein COS111.
Protein: RT4I1_MOUSE
Sequence: MGVLKTCVLRRSACAAACFWRRTVIPKPPFRGISTTSARSTVMPAWVIDKYGKNEVLRFTQNMMLPIIHYPNEVIIKVHAASVNPIDVNMRSGYGATALNMKRDPLHMKTKGEEFPLTLGRDVSGVVMECGLDVKYFQPGDEVWAAVPPWKQGTLSEFVVVSGNEVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLSDKNCKGKRALILGASGGVGTFAIQVMKAWGAHVTAVCSKDASELVRKLGADEVIDYTLGSVEEQLKSLKLFDFILDNVGGSTETWALNFLKKWSGATYVTLVTPFLLNMDRLGVADGMLQTGVTVGTKALKHLWQGVHYRWAFFMASGPYLDEIAELVDAGKIRPVIERTFPFSEVPEAFLKVERGHARGKTVVNVV
What is the function of this protein?
Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267).  Appears to be a potent inhibitor of regeneration following spinal cord injury (PubMed:12067236).
What are the official names of this protein?
Reticulon-4-interacting protein 1, mitochondrial, NOGO-interacting mitochondrial protein.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion outer membrane. Note=Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria.