PharMolix/UniProtQA huggingface dataset:
Protein: MET10_YEAST
Sequence: MPVEFATNPFGEAKNATSLPKYGTPVTAISSVLFNNVDSIFAYKSFSQPDLLHQDLKKWSEKRGNESRGKPFFQELDIRSGAGLAPLGFSHGLKNTTAIVAPGFSLPYFINSLKTVSHDGKFLLNVGALNYDNATGSVTNDYVTALDAASKLKYGVVTPISANEVQSVALLALAIATFSNNSGAINLFDGLNYSKTVLPLVESVPEASILAKLSKVIAPDAAFDDVLDKFNELTGLRLHNFQYFGAQDAETVFITYGSLESELFNSAISGNNSKIGLINVRVPLPFNVAKFVTHVPSTTKQIVVIGQTLDGSSPSFLRSQVSAALFYHGRTSISVSEYIYQPDFIWSPKAVKSIVSSFIPEFTYNADSSFGEGFIYWASDKSINIDVASKLVKALSLEDGKFVSLRTKFDNLANAGTFQAQFVTSKEQIPVSNIDSTKLSVVEDVSLLKHLDVAATVAEQGSIALVSQKAVKDLDLNSVESYVKNLGIPESFLISIAKKNIKLFIIDGETTNDESKLSLFIQAVFWKLAFGLDVAECTNRIWKSIDSGADISAASISEFLTGAFKNFLSEVPLALYTKFSEINIEKKEDEEEPAALPIFVNETSFLPNNSTIEEIPLPETSEISDIAKKLSFKEAYEVENKLRPDLPVKNFVVKVKENRRVTPADYDRYIFHIEFDISGTGMTYDIGEALGIHARNNESLVKEFLTFYGLNESDVVLVPNKDNHHLLETRTVLQAFVENLDIFGKPPKRFYESLIPYASNEEEKKKLEDLVTPAGAVDLKRFQDVEYYTYADIFELFPSVRPSLEELVTIIEPLKRREYSIASSQKVHPNEVHLLIVVVDWVDNKGRKRYGQASKYISDLAVGSELVVSVKPSVMKLPPSPKQPVIMSGLGTGLAPFKAIVEEKLWQKQQGYEIGEVFLYLGSRHKREEYLYGELWEAYKDAGIITHIGAAFSRDQPQKIYIQDRIKENLDELKTAMIDNKGSFYLCGPTWPVPDITQALQDILAKDAEERGIKVDLDAAIEELKEASRYILEVY
What is the function of this protein?
This enzyme catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein component.
Protein: YAOB_SCHPO
Sequence: MRSLSCIVCRQKKIKCDRKNPCTNCEQAGEKCMFKEYDSRKIRHPHSYVKALETRLAGLEAFWKRVKYAPVNEKLELLKTISFNDHLSPDISVSKTDTTFEFPVSLDIRGPNTIAFYGPTNVYGPPLTPSSPETPSFPPQNPSFSPLITDCLKLFFKWQYPQFLFINREAFLVDYYYRYHEGRYCSEHLLYAMCAIGSRMSVDPNIAALAKNFYQIAWNKIIEYGLGKSHITSIQCLLCLGYFNIGMGNTSLGWMLSGMAFRMGQDLGFQLNPRNWSVNDHPVVSPADAAVRSRIYWGSYVTDIFISFVLGRPTTLKKSDTSIPDSESLPDFDGVNEYRVNNALLLKEYLCIQSSVY
What are the official names of this protein?
Uncharacterized transcriptional regulatory protein C11D3.11c.
What are the subcellular locations of this protein?
Nucleus.
Protein: UN19_CLOPA
Sequence: XXFESXEMR
What are the official names of this protein?
Unknown protein CP 19 from 2D-PAGE.
Protein: PNCB_CROS8
Sequence: MTQYASPLLQTLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDLLGIYADAIREQVDAMQHLALSDAEYQWLSGLPFFKSDYLQWLKTFRYDPTQVQIRNDGGKLDIRLSGPWREVIMWEVPLLAVISELVHRYRSPEASVDQALAHLEVKLDDFRTMTDGLDLSAFRLMDFGTRRRFSRDVQQAIVERLKLEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQIAALQAWLDEYPDMLGIALTDCITMDAFLRDFGPEFAGRYQGLRHDSGDPVQWGEKAIAHYQQLGIDPLSKTLIFSDNLDFAKAIELYRHFADRVKLGFGIGTRLTCDIPHVKPLNIVIKLVECNGRPVAKLSDSPGKTICHDKAFVRALRKAFDLPQVRKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: NU2C_MAIRA
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFHGSFIFPECILIFGLILLLMIDSTSDQKDRPWFYFISSTSLVMSITALLFRWKEEPIISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKRDVRSNEATTKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALISTTVGIGFKLSPAPFHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFARIVSFGLRTGTDNIRDYAGLYTKDPFLALSSALCLLSLGGLPPLAGFFGKLHLFWCGWQAGLYFLVSIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIEWSMTVCVIASTIPGISMNPILAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2, chloroplastic, NAD(P)H dehydrogenase, subunit 2, NADH-plastoquinone oxidoreductase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: KCC4_MOUSE
Sequence: MLKVTVPSCPSSPCSSVTASTENLVPDYWIDGSNRDPLGDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDARDAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHTSIQENHKASSDPPSTQDAKDSTDLLGKKMQEEDQEEDQVEAEASADEMRKLQSEEVEKDAGVKEEETSSMVPQDPEDELETDDPEMKRDSEEKLKSVEEEMDPMTEEEAPDAGLGVPQQDAIQPEY
What is the function of this protein?
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation.  In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny.  In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2).  Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs).  Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2.  Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus.  Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2.  Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity).  May be involved in spermatogenesis.
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type IV, CaMK IV, CaM kinase-GR.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei (By similarity). In spermatids, associated with chromatin and nuclear matrix.
Protein: PYRR_ACTPJ
Sequence: MEKIIIDAEQFQRTISRISHQIIEKHSSLDNLVLVGIKRRGAEIAEMLQSRIAELAQTELPLMALDITFYRDDLHLDHQDPVYTGVESQIDITGKNVILIDDVLFTGRTIRAALDALLDFGRATRIELVILVDRGHRELPIRADYVGKNIPTARTEQVQVRTQFYDGMNQVVLIRAKDE
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: EIF3C_PICST
Sequence: MSRFFVAGYNSDSSSEEEDLLSSDEELLSSSSEGEQETSDDDSLDFDDQSDSDSSDSDSDGRPSGPAYFLKKDFMKGGAGGDSDSDSEDEGRRVVKSAKDKLLDDMNESIEAINVARRSDTWTTVVSEFDKLGRLLVRAGQQSVSTPNAYIRCLADLEDYITATSENEKTEKSLNAAEARAFNMAKQRVRKQIKEYQAQYDLYRENPELFEREESVDIAAPSRSDVPVEDTTGRVLSPVFTILKQIAETRGKKNIDKYEQIKTLEDLLNDNLAKGSVFELISIYQMLLSIRFDASANQNFMPIEQWKNNEADLTSLIGLLESNKDTYQLSELGSTTDDIDIEPVANESGVKAIFGSITSLIDRLDDEFTRSLQNTDPHSIEYVQRLKDETTIYQLIVRGQSYIESITPAEVQQSVEQLSRVVLRRLEHIYYKPDQLIKANEAEAWKGISHESVIVSKDSTPAELIEGLSSFLTKHKNPVYAKHALLFSVYYYAVNNNYNRAKELFLDSQIFNKIHHADSSLQVQYNRAIVQLGLSAFRNGAVEESHKVLNEIVNSQRSKELLGQGFNSKYPNQATTVEKAKLLPFHQHINLELLECVYSTCSLLIEIPALAAATNSKDSRRKATTKSFKSKLEFHDRQFFTGPPESIKDHIVHASIALSKGDWAKAYQLLSSIKIWKLFPDNDDLLAMMKNQLQVEGLRTYIFSYKSIFSKLSLGKLSQIFELEADKVESIVQKMIETNEIGGTLDESKAFIQFASTEPQRSRLQELAIVMNEKVGLLTEKNEKTSSNGYGKKQPQQQQQQQQQQQQQQQQQKDLLQEDNSRFRYANVNTNNDEFQTTA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 93 kDa subunit homolog, eIF3 p93, Translation initiation factor eIF3, p93 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMDH1_MOUSE
Sequence: MADYLISGGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKIQHGFSGIPITATGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRVELVVAPAGVTLKEANEILQRSKKGKLPIVNDQDELVAIIARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGAQSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.  Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism.  It may also have a role in the development of malignancy and the growth progression of some tumors.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase 1, IMP dehydrogenase 1, IMPD 1, IMPDH 1, IMPDH-I.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PEPX_LACHE
Sequence: MKYNQYAYVETDFQQQVKELIDINFLPKNYQVWDFSSLLAKLVKNAIAEAKTDAAKNAKLAEFAVSDHQTLADFLKEKPTEIGTKQFYNVALQLLGYHVHYDYDFADPTGFMQRNALPFLQDISDNQKLISAFYRLLNTRAKNGQILLDVMAGKGYFTQFWGQNKFKFFNGKSIPVFDTNKVIREVVYVETDLDTDHDGKSDLIQVTVFRPEETNKGLKVPALYTASPYFGGIIANEKRNHNVDENLSDSTEWNDPQYVHSPIVKAEKPDGSSRPATEEAVHKSSYPLNEYMLARGFASVFAGAIGTRGSDGVRITGAPEETESAAAVIEWLHGDRVAYTDRTRTVQTTADWCNGNIGMTGRSYLGTLQIAIATTGVKGLKTVVSEAAISSWYDYYREHGLVIAPEACQGEDLDLLAETCQSNLWDAGSYLKIKPEYDKMQKQLREKEDRNTGQYSDFWEARNYRHHADGIKCSWISVHGLNDWNVKPKNVYKIWQLVKKMPMKHHLFLHQGPHYNMNNLVSIDFTDLMNLWFVHELLGIENNAYNQWPTVMIQDNLQADKWHEEPDWSNDLGQEKIYYPTDEGELFQDGNGKAQKSFTDVGGIEFKKAGISESDWQYKFICGDEKWAKPSLRFETDEFTHPTTIVGRPEVKVRVSASLPKGEISVALVELGERQRLTATPKFLMHGGQELGYRFGTDTLQEFVPDKKTKAKLITKAHMNLQNFKDMKKPEAIDADKFYDLDFLLQPTYYTIPSGSKLALIIYSTDQGMTKRPLEDETYTIDLANTEIKFYEK
What is the function of this protein?
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Xaa-Pro dipeptidyl-peptidase, X-Pro dipeptidyl-peptidase, X-prolyl-dipeptidyl aminopeptidase, X-PDAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URED_YERPB
Sequence: MTAQSQNIVETPSRVRAHALGVNAPELAKYQDEPAQMRSGAVGKSGYLKLRFAKREHRSILAEMERRVPSLVQKALYWDEEIPELPCVTMISTSGCILQGDRLATDVHVEAGACAHVTTQSATKVHMMNANYASQIQNFIVEEGGYLEFMPDPLIPHRNSRFITDTTISIHPTATAIYSEVLMSGRKYHHADERFGFDVYSSRVAAQNLAGKELFVEKYVLEPKVESLDAVGVMQTFDAFGNVILLTPKEHHDRILARVPAHFDIKGGIASGATRLPNDCGLVFKALGIDSAGVKAEIRQFWKIAREEILGVTLPEQFLWR
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFEO_SALPK
Sequence: MFHPRARTMLLLSLPALIIGVASSLVLIAAMKIASVFQQFLWQRLPASIGIAYDSPFWIVGMLTLTGIVVGLIIRYSPGHAGPDPAIEPLISMPVSPSALPGLLLALIIGLAGGVSLGPEHPIMTINIALAAAFGSRLFPRITALDWTILASAGTIGALFGTPVAAALIFSQTLSGSNDIPMWDRLFAPLMAAAAGSLTTSLFFHPHFSLPIAHYTQMRLVDIASGAIVAAIAIAAGMVAVWCLPRLHELLHRLKNPVLILGIGGFILGILGVIGGPLTLFKGLDEMQQMAFSQTLGAGDYFTLAVVKLAALVIAAASGFRGGRIFPAVFIGAALGLMLHAHVEAVPAAITVSCAILGLVLVVTRDGWLSLFMAAVVVPDTNLLPLLCIVMLPAWLLLAGKPLLAANRHEP
What are the official names of this protein?
Putative ion-transport protein YfeO.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PUR7_PHEZH
Sequence: MTRRKKIYEGKAKILYEGPEPGTLIQYFKDDTTAFDATKKAVLEGKGVINNRISEYIMTKLNSIGVQNHFIKRLNLREQLIREVEIIPLEVVCRNVAAGSLSKRFGLPEGQALPRSIIEFYLKDDKLHDPMVAEEHITAFNWASTQEIDDMMALTLRVNDFLTGLFSGVGITLVDFKIEFGRIWENDFSRIILADEISPDSCRLWDSQTNEKLDKDRFRRDLGNVIESYTEVARRLGIMKEMPTVIQGGLH
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RS11_HAES1
Sequence: MAKTPVRTRKRVKKQVVDGVAHIHASFNNTIVTITDRQGNALAWATAGGSGFRGSRKSTPFAAQVAAERCAEVVKEFGLKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: HOA_SPHYA
Sequence: MTFNPETGKLYIQDVTLRVGMHAILHMYGTESVRTIAKALDDAGVDAIEVSHGDGLNGTSFNYGFGAHTDWEWIEAAADVIKNAVLTTLLVPGIGTVEELRRAYALGVRSVRVATHCTEADVAKQHIGIARDLGMDVSGFLMMSHMIDAEALAQQALLMESYGAHCVYVTDSGGALDMDGVRDRLRAYDRVLKPETQRGIHAHHNLSLGVANSIVAAQEGAVRIDASLAGMGAGAGNAPLEVFVAAADRKGWNHGCDVMALMDAAEDIIRPLQDRPVRVDRETLSLGYAGVYSSFLRHAEKAAEQYGLDTREILIELGKRRMVGGQEDMIVDVALDLVSARAA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase, HOA, 4-hydroxy-2-keto-pentanoic acid aldolase, 4-hydroxy-2-oxopentanoate aldolase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: CP191_CARAU
Sequence: MEEVLKGTVNFAAAVQVTLMALTGTLLLILLHRIFTAKNWRNQSGVPGPGWLLGLGPIMSYSRFLWMGIGSACNYYNEKYGSIARVWISGEETFILSKSSAVYHVLKSNNYTGRFASKKGLQCIGMFEQGIIFNSNMALWKKVRTYFTKALTGPGLQKSVDVCVSATNKQLNVLQEFTDHSGHVDVLNLLRCIVVDVSNRLFLRIPLNEKDLLIKIHRYFSTWQAVLIQPDVFFRLNFVYKKYHLAAKELQDEMGKLVEQKRQAINNMEKLDETDFATELIFAQNHDELSVDDVRQCVLEMVIAAPDTLSISLFFMLLLLKQNSVVEEQIVQEIQSQIGERDVESADLQKLNVLERFIKESLRFHPVVDFIMRRALEDDEIDGYRVAKGTNLILNIGRMHKSEFFQKPNEFNLENFENTVPSRYFQPFGCGPRACVGKHIAMVMTKAILVTLLSRFTVCPRHGCTVSTIKQTNNLSMQPVEEDPDSLAMRFIPRAQNICGDPHLGEKTEE
What is the function of this protein?
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
What are the official names of this protein?
Brain aromatase, CYPXIXA1, Cytochrome P-450AROM, Cytochrome P450 19 type 1, Estrogen synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: SHO1_TALSN
Sequence: MPRFDPSNILGDPFALSTISISIIAWIISFIGSIIADVQTDFPNYAWWAVAYMICVIAGIIVVVGSDTTLIYSNAVVGYLSAGLAFTTLAVNSLVYQPQSSKQAAAAGFILLSMINIIWIFYFGSTPESSHRQAIDSLALNKVGNAYHNSRPASNAFGARPATTVSQPPQMYTSAQLNGFETSSPMSGYPGGPPGSDKRNTTATNFPPANVEPSNEVSQPTEYPYKAKAIYSYDANPDDANEISFTKGEELEVSDVSGRWWQARRANGETGIAPSNYLILL
What is the function of this protein?
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
What are the official names of this protein?
High osmolarity signaling protein sho1, Osmosensor sho1.
What is the protein family that this protein belongs to?
Belongs to the SHO1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FABH_PHOV8
Sequence: MEKINAVITGVGGYVPDYVLTNEEISRMVDTNDEWIMTRIGVKERRILNEEGLGTSYMARKAAKQLMQKTASNPDDIDAVIVATTTPDYHFPSTASILCDKLGLKNAFAFDLQAACCGFLYLMETAASLIASGRHKKIIIVGADKMSSMVNYQDRATCPIFGDGAAACMVEATTEDYGIMDSILRTDGKGLPFLHMKAGGSVCPPSYFTVDHKMHYLYQEGRTVFKYAVSNMSDITATIAEKNGLNKDNIDWVIPHQANLRIIDAVASRLEVPLEKVMINIQRYGNTSGATLPLCLWDYEKQLKKGDNLIFTAFGAGFTYGAVYVKWGYDGSKR
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_TRIV2
Sequence: MKSIMVVGTTSHAGKSLISTAICRILSRRGWRVAPFKGQNMALNAYVTANGGEIGYAQAVQAWAAGVVPWVEMNPILLKPQGDMTSQVIIRGRPVGRVNAADYYEQYFEPGWRAIEESLQHLGTEFDLVVCEGAGSPAEINLKHRDLTNMRVAKYLNAPTLLVVDIDRGGAFAHVVGTLELLEPEERQLIKGVVINKFRGQRSLLDPGIKWLEERTGIPVVGVIPYLQEIFPAEDSLDLLERKTHKAHADLQITVVRLPRIANFTDFDPLESEPTVAVKYISPKQDLGHPDAVILPGTKTTIADLILLQKTGMAEAIQNYAASGGTVLGICGGYQILGQMIADPEGIEGQAGRYQGLNLLPIRTVITGQKIARQRQVSSNFPQLGLPVNGFEIHQGRSRVEPQGDSQAFQPLFDDVNLGLVDSCQSVWGSYLHGLFDNGPWRRAWLNRLRQQRGLKSLPTGVANYREQREQMLDNIATEVENHLDLTLFLP
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: 5EAS_TOBAC
Sequence: MASAAVANYEEEIVRPVADFSPSLWGDQFLSFSIKNQVAEKYAKEIEALKEQTRNMLLATGMKLADTLNLIDTIERLGISYHFEKEIDDILDQIYNQNSNCNDLCTSALQFRLLRQHGFNISPEIFSKFQDENGKFKESLASDVLGLLNLYEASHVRTHADDILEDALAFSTIHLESAAPHLKSPLREQVTHALEQCLHKGVPRVETRFFISSIYDKEQSKNNVLLRFAKLDFNLLQMLHKQELAQVSRWWKDLDFVTTLPYARDRVVECYFWALGVYFEPQYSQARVMLVKTISMISIVDDTFDAYGTVKELEAYTDAIQRWDINEIDRLPDYMKISYKAILDLYKDYEKELSSAGRSHIVCHAIERMKEVVRNYNVESTWFIEGYTPPVSEYLSNALATTTYYYLATTSYLGMKSATEQDFEWLSKNPKILEASVIICRVIDDTATYEVEKSRGQIATGIECCMRDYGISTKEAMAKFQNMAETAWKDINEGLLRPTPVSTEFLTPILNLARIVEVTYIHNLDGYTHPEKVLKPHIINLLVDSIKI
What is the function of this protein?
Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol (Ref. 3, PubMed:16375847).  Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene (Ref. 3, PubMed:16375847).
What are the official names of this protein?
5-epi-aristolochene synthase, TEAS.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN1_ARTOC
Sequence: MGIKSLYQIISENAPDAIKAGEIKNQFGRKVAIDAYVKTAQRYRASTDEEQLTNESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTMRKAEAQEAAEEAKETGTAEDVEKFSRRTVRVTREHNAECKRLLKLMGIPYIDAPTEAEAQCAVLAKEGKVFGAASEDMDTLCFAAPVLLRHLTFSEQRKEPILEIHLDKVLEGLGMEMTQFVDLCILLGCDYLDPIPKVGPNTALKMIRDHGTLEKVVETIESDPKKKYVIPDDWPYLQARDLFFNPDVRPADAPECDFKWTAPDVEGLVRFLVEEKGFSEDRVRNGAARLTKNLKSAQQSRLEGFFKPVAKTEQQKATAKRKAEEKAELAKKKKKEDAKAKRAMGAKPRGAR
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: UTP10_CANAL
Sequence: MSSLASQLQSINEKTASVALDRKQRSKLHSRSLIFDPKQAATQDYEYIYEIATEGLEDLCELDSRFNKFKSTLFSETSVNLDRNLQTKDVISQLDKNIDAFLTLVGPYYGLTSSLKAVEWLVRRFHANIHNAELMILTALPYFQHPVFVKVLNVIPKQNLPQIFEWLVGYKDQLKTPPASSILKAFRNDFHFFNFYSKFLNDQIKNHTVYKEQLVFYLSNTVQLLASFSKNIEELNETHIPVVLETTALMLLPQQKPKYSSSINSDLKLTSYSIISVLSSIFPFSADILKSLTVSILEDEDALKGFTKPTLIVLSQLWKHFQGNLEVIEAFKNFKIGQHELGVLDELKNENYQLSTFIILVFISTFPSNESYKLLPFIDLSNKTVFEIITKLVLQNSTTQEDSIRSNLTKIAQSLTKSDPKLFQTTLESENWKVDELELKLMSVLVESKNDEAEFDAGDEDNAVEDIEIVKTVDFTKLQSTAKSYFNTEYDEEFNLVLKELKSVLSASDAKLHVSVILTFLQKVFSTPEVALTFAFRVALTPAVPLSIRLSAIKSIRIKIKNAANGKTDFYLLIPLILLALFDNSKLIRSGFAQLLRLVIEIKTKLTTGAALFLEREIYGSVSDKKYPTPHDSLFLCSLLSEDNVKDTVLDPSRVINILFDSIFKAKNGKSKPGKYFRSFIFTQWSLCSLPIVLKANAWKIVAQANKAGTDDRFFFLDGDIENYFSKRNVWIDQASIAGIAFFDNAEVSVVGLVGGVASNDKNSNTESEWLCRALENPSGNLQMTANNRVLETFDTFKPIESRLKIVNKLVDILINDDIVEFDPMATLQELNIDRNLFLQALTSVQIGDQIPEQGIAKRRRRSSNSTKQAMVRDEINNMASGHLKKLTFLLEILESSLRKKRNVAGPDLLKVLFKILTDLEYLGNDGNLPVLYAQETLASCMLLNIVNLKSSSKEVKFDSNSIRADLIVNSIRASPSPQVQNRLLLVISELASLAPEVILHSVMPIFTFMGAHTVRQDDEFSSSALQQTVAKVIPALASNGLSPVNNEIEFLLASFATAFPHVPRHRRVKLFVSLTKTLGCAESMHLILFLMGQQYANNVHKNKNGDSQSVVEFVHGYMKSFSAEEQLAGIVAFTKLWNDIPLNQLEPGSEEFEVLNNRPVFGTTIATLGQSGLAVLRNDLLQFLDETLSSENKHELSSLKTKMALVLIDDEDSEVSKKESVLDKFRAITSFALASLDTFTNSHADIKLCSTLYSLLGNLLDLLPLNYFIDSIVASLDVDTLSDSLSIKVARNYAILASRKFETELNVAHCDQVVIESVINNLLPILIKGIKKNVDVELQQAYLDTFSTIVNKFGASGTEFASSDVSKVLIESLGIVTTDRGLLNEQPEVIIASINAITSIVNILGVKTLGLFPKVVPPALKIWESTNSLGDKESAKLLQGSVLVLLSCYIKKIPAFMSTTLEAVLLTILSSDLIDNHIRSSVLDLIVDHMDLAQVLKSLCNVWLTKKFYTNDNSGNIGLFLKTLQATINKMEKKQATTQATLFMRWLISAFEFRQYSEDNDNKFDNNTIHRLESSFHGCAIAFVMKLNDKSFRPLFANLVRWAVDGEGATLKTNEVSRLLAFFRFFNKLQDELKSIITSYFSYLLDPTSALLKRFSEGSLVATNLRRIILIGLTSSFKYDQDDYWSQQGRFDSICSPLLSQLSNIEDSIGKYLVKSVSTFVTDVSSDEYNETLVHELIKYISNANENSAATKIWSIRTLKTIFQKMGEQWLSYLPTLVPYIAELLEDDDEEVEMEVRRGLVRVIENVLGEPLDRYLS
What is the function of this protein?
Involved in nucleolar processing of pre-18S ribosomal RNA.  Involved in ribosome biosynthesis (By similarity).
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 10.
What is the protein family that this protein belongs to?
Belongs to the HEATR1/UTP10 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Membrane; Single-pass membrane protein.
Protein: DUT_SHEPW
Sequence: MKTPIELKILDSRIGTQFPLPAYATLGSAGMDLRAITDIALTIQPGETVLIPTGIAVHVADPSLAAIILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRGSEPFTIEIGDRLAQLVFVPVVQAEFKLVDEFDSSDRGAGGFGHSGTK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.