PharMolix/UniProtQA huggingface dataset:
Protein: EREP2_HUMAN
Sequence: MPPAGGPRAPRPAALPRSLSRLRECPGRSRIVLALGATQMALGCLIVAVSFAALALTTSARVRHSCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSILSCQNAQLVNSLEGCQLIKFDSVEVCVCCELQHQSSGCSNLGETLKLNPLQENCNAVRLTLKDLLFSVCALNVLSTIVCALATAMCCMQMVSSDVLQMFLPQRSHPANPTCVTPHGTVLHQTLDFDEFIPPLPPPPYYPPEYTCTPSTEAQRGLHLDFAPSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTATPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSATAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPRSLVDSKAYADARVLVAKFLEHSHCALPTEAQHMVGAMRLAVTNEERLEEEAVFGADVLDQV
What are the official names of this protein?
Protein ENTREP2, Endosomal transmembrane epsin interactor 2, Transmembrane protein 228.
What is the protein family that this protein belongs to?
Belongs to the ENTREP family.
Protein: MDM34_SCHPO
Sequence: MSFRVKGWSDQFSESFYERATTLLTAALNKGTKHSMIADHITVKELDLGPQPPQLEILEVGDLAPDRFQGLFNLHYSGDASLVLQTKIRANPLSVQKSNVPSFSSRNTMLASRAPLTVPMFLRLSDLKLNGIVVLVFSKQKGITVVFRNDPLESVRVSSSFDSIPAIARFLQREIEVQLVSLFQEELPSIIYKMSRIWFAKSDSNLSFQKIPFTSPNQSHTSLANYNPDLLDGPPDYHESTKVDTHLPIKMGPLDVQTHPNIRSIASLALSRKALLPISSPSIPMSIYRSTPPDTIIQQLTTQSDDISAVSSPATQYSASDYLGSNDTTARPSIFGRSHGTSQFRRRERVKKRHVIKIHEASNKSASSSETFVGSKNVDLTESAFDSIPDTPTKIITNINKLKRNYTITNNWLENLQQKIPSEVDNGKVSGLQYSAFKLLMLQRLMAAKGSF
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: YQGB_ECOLI
Sequence: MKKKPVAQLERQHSLLENPCAYGLLSQFQAAIVVNCFTLNKII
What are the official names of this protein?
Uncharacterized protein YqgB.
What is the protein family that this protein belongs to?
Belongs to the YqgB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_STRZJ
Sequence: MKIDILTLFPEMFSPLEHSIVGKAREKGLLDIQYHNFRENAEKARHVDDDPYGGGQGMLLRAQPIFDSFDAIEKKNPRVILLDPAGKQFDQAYAEDLAQEEELIFICGHYEGYDERIKTLVTDEISLGDYVLTGGELAAMTMIDATVRLIPEVIGKESSHQDDSFSSGLLEYPQYTRPYDYRGMVVPDVLMSGHHEKIRQWRLYESLKKTYERRPDLLEHYQLTVEEEKMLAEIKENKE
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPS_SHEON
Sequence: MSSTVEFDPQSRPTEADAYAQTSLPEVLPELVKQSLPKHVAIIMDGNGRWAQTQGKPRVMGHKAGVKAVRRAVSAASQLGIQSLTLFAFSSENWRRPDKEVSLLMELFFTVLQREIKLLDKNQVKLNIIGDISRFSARLQKQIRAAEEKTAGNSGLILNVAANYGGRWDILQAAQKLAEKVETGEMTSSQFTEEALSEHLCMQNQSEVDLIIRTGGDYRISNFVLWQAAYAELVFLDTLWPDFDEQAFHEAIATFANRQRRFGLTGSQIDEMRAL
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP).  UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
What are the official names of this protein?
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), Ditrans,polycis-undecaprenylcistransferase, Undecaprenyl diphosphate synthase, UDS, Undecaprenyl pyrophosphate synthase, UPP synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: RL34_STACT
Sequence: MVKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: BARH1_MOUSE
Sequence: MEGSNGFGIDSILSHRAGSPALPKGDPLLGDCRSPLELSPRSESSSDCSSPASPGRDCLETSTSRPGAASGPGLDSHLQPGQLSAPAQSRTVTSSFLIRDILADCKPLAACAPYSSSGQPAAPEPGGRLAAKAGEDFRDKLDKSVSSASSDSEYKVKEEGDREISSSRDSPPVRLKKPRKARTAFTDHQLAQLERSFERQKYLSVQDRMELAASLNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYPQSLVSNLDPGAALYLYRGPSAPPPALQRPLVPRILIHGLQGASEPPPPLPPLPGVLPRAAQPR
What are the official names of this protein?
BarH-like 1 homeobox protein, Bar-class homeodomain protein MBH2, BarH-related homeobox protein 1.
What is the protein family that this protein belongs to?
Belongs to the BAR homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYS_CLOTE
Sequence: MLDLKRIRSNPEEIKKALAGRGEDFDVSVIDKVLQLDEERRNILVEVESLKNKRKQESAKIPQFKKEGKNVDDIMAEMKELAGKIKKLDERLSEIDGSIEYIMLRIPNIPNPNVPNGDSDEDNVEIRRWGEATTFEFEPKAHWDLGVNLDILDFERAGKVTGSRFTFYKGLGARLERAVINYYLDTHIDEHGYTEILPPYMVNRKSMTGTGQLPKFEEDAFRLEEQDYFLIPTAEVPVTNLYRDEILNGSDLPMKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTKDAEDVLQGLGIPYRVVRICKGDLGFTAALKYDIEVWMPSYNRYVEISSCSNFEDFQSRRANIKYRENPKDKPNFVHTLNGSGVAVGRTVAAIIENFQQADGTIIIPEKLRPYMGGKDVIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FXYD6_MACFA
Sequence: MELVLVFLCSLLAPMVLASTAEKEKEMDPFHYDYQTLRIGGLVFAVVLFSVGILLILSRRCKCSFNQKPRAPGDEEAQVENLITANATEPQKAEN
What are the official names of this protein?
FXYD domain-containing ion transport regulator 6, Phosphohippolin.
What is the protein family that this protein belongs to?
Belongs to the FXYD family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CEP76_MOUSE
Sequence: MSLPPEKASELKQLIHQQLSKMDVHGRIREILAETIREELAPDQQHLSTEDLIKALRRRGIIDDVMKELNFVTDSVDQELPSSPKQTVGFDKQSTLKKTNVDPTRRYLYLQVLGGKAFLEHLQEPEPLPGQICSTFTLCLHYRNQRFRSKPVPCACEPDFHDGFLLEVHRESLGDGTRMADSTTMLSISDPIHMVLIKTDIFGETTLVASYFLEWRSVLGSENGVTNLTVELMGVGTESKVSVGILNIKLEMYPPLSQTLSQEVVNTQLALERQKTAEKERLFLVYAKQWWREYLQIRPSHNSRLVKIFAQDENGINRPVCSYVKPLRAGRLLDTPRQAARFVNVLGYERAPVIGGGGKQEQWCTLLAFLCRNKGDCEDHANLLCSLLLGYGLEAFVCVGTKAKGAPHAWVMTCGTDGTIMFWESLTGHRYIHKPTNPDGPPLAEQPKPLYPYRTIGCVFNHQMFLGNCQPSDAVETCIFDLNDESKWKPMSEEAIKSVCAPGATTSLPPFPPLCASTIDASVTSNEIEMQLRLLVSEHRKDLGLTTVWEDQLSYLLSPALASYEFERTTSISAGNEEFQDAIRRAVPDGHTFKGFPIHFVYRNARRAFATCLRSPFCEEIICCRGDQVRLAVRVRVFTYPESACAVWIMFACKYRSVL
What is the function of this protein?
Centrosomal protein involved in regulation of centriole duplication.  Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (By similarity).
What are the official names of this protein?
Centrosomal protein of 76 kDa, Cep76.
What is the protein family that this protein belongs to?
Belongs to the CEP76 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Does not localize along the ciliary axoneme.
Protein: ANK3_MOUSE
Sequence: MSEEPKEKPAKPAHRKRKGKKSDANASYLRAARAGHLEKALDYIKNGVDVNICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDTNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRSAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKASPNAKALNGFTPLHIACKKNRIRVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLAAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVASLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATSLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTALHQAAQQGHTHIINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTLKVVTEEIMTTTTITEKHKMNVPETMNEVLDMSDDEVRKASAPEKLSDGEYISDGEEGDKCTWFKIPKVQEVLVKSEDAITGDTDKYLGPQDLKELGDDSLPAEGYVGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPVHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLAELLNGMDEELDSPEELGTKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPEETVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDATPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLASQLYRELICVPYMAKFVVFAKTNDPVESSLRCFCMTDDRVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKAEKADRRQSFASLALRKRYSYLTEPSMSPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGHPSFQVELETPMGLYCTPPNPFQQDDHFSDISSIESPFRTPSRLSDGLVPSQGNIEHPTGGPPVVTAEDTSLEDSKMDDSVTVTDPADPLDVDESQLKDLCQSECAQCWASVPGIPNDGRQAEPLRPQTRKVGMSSEQQEKGKSGPDEEVTEDKVKSLFEDIQLEEVEAEEMTEDQGQAMLNRVQRAELAMSSLAGWQNETPSGSLESPAQARRLTGGLLDRLDDSSDQARDSITSYLTGEPGKIEANGNHTAEVIPEAKAKPYFPESQNDIGKQSIKENLKPKTHGCGRTEEPVSPLTAYQKSLEETSKLVIEDAPKPCVPVGMKKMTRTTADGKARLNLQEEEGSTRSEPKQGEGYKVKTKKEIRNVEKKTH
What is the function of this protein?
Membrane-cytoskeleton linker.  May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity).  In skeletal muscle, required for costamere localization of DMD and betaDAG1.  Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368).
What are the official names of this protein?
Ankyrin-3, ANK-3, Ankyrin-G.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, axon. Cell membrane, sarcolemma. Postsynaptic cell membrane. Lysosome. Cell membrane, sarcolemma, T-tubule. Note=In skeletal muscle, localized at costameres and neuromuscular junctions. In bone marrow-derived macrophages, isoforms 2 and 3 are associated with lysosomes.
Protein: CSRA_VIBCM
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYMRIQAEKGNGGVASGNY
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y904_BURMA
Sequence: MADPQLITTAFDIPGYRIERSLGVARGIVVRSRSIVGTFGASIQTLFGGNISLYTSLCERARQDAYERMIDEARRMGGNAIVGMRYDATEIASGVTEVLCYGTAVQAVRAG
What are the official names of this protein?
UPF0145 protein BMA0904.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: LEU3_THET8
Sequence: MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_SULNB
Sequence: MSRALLKFVRVSPTKARLIAREVQGMNAELALASLEFMPNKAAGIISKVIASAVANGDFEPEEVEITSCRVDKAAVMKRWRPRARGTASRIIKPTAHILVEVGPAKKDGEDA
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: OCP3_CALMC
Sequence: GSWD
What is the function of this protein?
Cardioactive; has both positive chronotropic and inotropic effects on the heart.  Ocp-4 is a 1000 time less active than Ocp-3.
What are the official names of this protein?
Cardioactive peptide Ocp-3/Ocp-4.
What are the subcellular locations of this protein?
Secreted.
Protein: RIBC_LISMO
Sequence: MEVSHVTLAPNKDSRAAVLTIGKFDGVHIGHQTILNTALSIKKENEILTAISFSPHPLWALKQIEIYREMLTPRMEKERWLAYYGVNHLIETEFTSRYAETTPEEFVTDHLTNLNLSHIVVGSEFNFGKGRDSDVDLLRDLCKPYDIGVTSVPVIETNQTKISSTNIRAFIRRGHFQEAEELLGHPWYITGIVENGEMTGLDDYVLPATGTYQTDSGIVNVTNNRTIEVGLSDGLQQLHMKNELSE
What is the function of this protein?
Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme (PubMed:27672192).  Can also catalyze, with lower efficiency, the adenylation of the toxic riboflavin analogs 8-demethyl-8-aminoriboflavin mononucleotide (AFMN) and roseoflavin mononucleotide (RoFMN) to 8-demethyl-8-aminoriboflavin adenine dinucleotide (AFAD) and roseoflavin adenine dinucleotide (RoFAD), respectively (PubMed:27672192).
What are the official names of this protein?
FAD synthetase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase.
What is the protein family that this protein belongs to?
Belongs to the RibF family.
Protein: MUTH_VIBVY
Sequence: MKPIPQTEAELLQRANQIAGCSFAELAEEANMDVPLDLKRDKGWVGQLLEWHLGAPAGSKPQQDFSELGIELKSIPVSYSGKPLETTFVCVAPLTGVHGLTWETSHVRNKLSRVLWIPVEGEREIPLAERHVGTPLLWSPNDEEEILLKNDWEELMEMIVFGQFDQISARHGVALHLRPKAANSKALTEAYNINGKPIKTLPRGFYLRTQFTAQILQNAFNSLLNEE
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_BRUSI
Sequence: MSQQNGNVNRVGAQDRVGASGGMEHSFGFKAVDENEKQGLVNDVFHKVAKRYDIMNDLMSAGMHRVWKDAMVAWLAPSKRPGWTSLDVAGGTGDIAFRIVEASGRQAHVTILDINGSMLGVGRERAIKKGLIDNLEFVEANAEELPFEDNSFDAYTIAFGIRNVPHIDKALSEAYCVLKPGGRFLCLEFSEVELPVLDKVYDEWSFRAIPRIGKMITGDADSYSYLVESIRKFPKQQDFAAMIEKAGFERVSYRNFTGGIAALHSGWKL
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: IF2G_RAT
Sequence: MAGGEAGVTLGQPHLSRQDLATLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD
What is the function of this protein?
As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis.  In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation.  The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing.  This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP.  Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome.  In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity).  Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 2 subunit 3, X-linked, Eukaryotic translation initiation factor 2 subunit gamma, X-linked, eIF-2-gamma, eIF-2-gamma X, PP42.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: RL13_HALHL
Sequence: MKTYSAKPAEVQRDWYLVDATDKTLGRLASEVAHRLRGKHKPVFTPHVDAGDYIVVINADKIRLTGRKERDKQYFWHTGFPGGIKSRSVAEVRERHPERLIESAVRGMMPKNRLGRAMLKKLKVYAGNEHRHHAQQPQPLEL
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: SMIM8_BOVIN
Sequence: MSSAPEPPAFKKEPPKEKDLGNIGLRGVRTTTLFRAVNPELFIKPNKPVMAFGLITISLCVAYIGYLHATQENKKDLYEAIDSEGHSYMRRKTSKWD
What are the official names of this protein?
Small integral membrane protein 8.
What is the protein family that this protein belongs to?
Belongs to the SMIM8 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SYGB_ESCF3
Sequence: MSEKTFLVEIGTEELPPKALRSLAESFAANFTAELDNAGLAHGTVQWFAAPRRLALKVANLAEAQPDREIEKRGPAIAQAFDAEGKPSKAAEGWARGCGITVDQAERLTTDKGEWLLYRAHVKGESTEALLPNMVATSLAKLPIPKLMRWGASDVHFVRPVHTVTLLLGDKVIPATILGIQSDRVIRGHRFMGEPEFTIDNADQYPEILRERGKVIADYEERKAKIKADAEEAARKIGGNADLSESLLEEVASLVEWPVVLTAKFEEKFLAVPSEALVYTMKGDQKYFPVYANDGKLLPNFIFVANIESKDPQQIISGNEKVVRPRLADAEFFFNTDRKKRLEDNLPRLQTVLFQQQLGTLRDKTDRIQALAGWIAEQIGADVNHATRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEAEDVAVALNEQYQPRFAGDDLPSNPVACALAIADKMDTLAGIFGIGQHPKGDKDPFALRRAALGVLRIIVEKNLNLDLQTLTEEAVRLYGDKLTNANVVDDVIDFMLGRFRAWYQDEGYTVDTIQAVLARRPTRPADFDARMKAVSHFRTLDAAAALAAANKRVSNILAKSDEVLSDRVNASTLKEPEEIKLAMQVVVLRDKLEPYFAEGRYQDALVELAELREPVDAFFDKVMVMVDDKELRINRLTMLEKLRELFLRVADISLLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA1A1_CONLE
Sequence: LTLDRASDDTDVAAEIMSGLIALAIDSCCSDSDCNANHPDMCS
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity).  Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity).
What are the official names of this protein?
Alpha-conotoxin-like Leo-A1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: H2B2_CHLRE
Sequence: MAPKKDEKPATRAATQEAGVEATAKAEAKPKAEKAAKKAKKEPAKKAAKEPKGDGEKKDKKKKSAVETYKLYIYKVLKQVHPDTGISSKAMSIMNSFINDIFEKVATEASKLSRYNKKPTVTSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.2, H2B-II.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: APAG_ECOUT
Sequence: MINSPRVCIQVQSVYIEAQSSPDNERYVFAYTVTIRNLGRAPVQLLGRYWLITNGNGRETEVQGEGVVGVQPLIAPGEEYQYTSGAIIETPLGTMQGHYEMIDENGVPFSIDIPVFRLAVPTLIH
What are the official names of this protein?
Protein ApaG.
Protein: RS6_IDILO
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYSETIKQGGGQIHRLEDWGRRQLAYPINKLHKAHYVLLNIEASAEVVEELETAFRYNDAVLRNMIMRKKESITEPSPLTKPKEDRKGDSEAA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: LRKS6_ARATH
Sequence: MNHHHYSLVIFHLILFLSLDFPTLSHRFSPPLQNLTLYGDAFFRDRTISLTQQQPCFPSVTTPPSKPSSSGIGRALYVYPIKFLEPSTNTTASFSCRFSFSIIASPSCPFGDGFAFLITSNADSFVFSNGFLGLPNPDDSFIAVEFDTRFDPVHGDINDNHVGIDVSSIFSVSSVDAISKGFDLKSGKKMMAWIEYSDVLKLIRVWVGYSRVKPTSPVLSTQIDLSGKVKEYMHVGFSASNAGIGSALHIVERWKFRTFGSHSDAIQEEEEEKDEECLVCSGEVSENPKEIHRKGFNFRVTVVGLKIPVWSLLPGLAAIVILVAFIVFSLICGKKRISEEADSNSGLVRMPGRLSLAEIKSATSGFNENAIVGQGASATVYRGSIPSIGSVAVKRFDREHWPQCNRNPFTTEFTTMTGYLRHKNLVQFQGWCSEGTETALVFEYLPNGSLSEFLHKKPSSDPSEEIIVLSWKQRVNIILGVASALTYLHEECERQIIHRDVKTCNIMLDAEFNAKLGDFGLAEIYEHSALLAGRAATLPAGTMGYLAPEYVYTGVPSEKTDVYSFGVVVLEVCTGRRPVGDDGAVLVDLMWSHWETGKVLDGADIMLREEFDAEEMERVLMVGMVCAHPDSEKRPRVKDAVRIIRGEAPLPVLPARRPLLRIRPANEAEEMIVDGLVGEDLPWMTPKSHFS
What is the function of this protein?
Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae.
What are the official names of this protein?
L-type lectin-domain containing receptor kinase S.6, LecRK-S.6.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the leguminous lectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.