PharMolix/UniProtQA huggingface dataset:
Protein: DXS_CAMJ8
Sequence: MSKKFAHTQEELEKLSLKELENLAASMREKIIQVVSKNGGHLSSNLGAVELSIAMHLVFDAKKDPFIFDVSHQSYTHKLLSGKEEIFDTLRQINGLSGYTKPSEGDYFVAGHSSTSISLAVGACKAIALKGEKRIPVALIGDGALSAGMAYEALNELGDSKFACVILLNDNEMSISKPIGAISKYLSQAMATQFYQSFKKRIAKMLDILPDSATYMAKRFEESFKLITPGLLFEELGLEYIGPIDGHNLGEIISALKQAKAMQKPCVIHAQTIKGKGYALAEGKHAKWHGVGAFDIDSGESVKKSDAKKSATEIFSKNLLDLASKYENIVGVTAAMPSGTGLDKLIEKYPNRFWDVAIAEQHAVTSMAAMAKEGFKPFIAIYSTFLQRAYDQVIHDCAIMNLNVVFAMDRAGIVGEDGETHQGVFDLSFLAPLPNFTLLAPRDEQMMQNIMEYAYLHQGPIAFRYPRGSFILDKEFNPCEIKLGKAQWLVKNNSEIAFLGYGQGVAKAWQVLRALQEMNNNANLIDLIFAKPLDEELLCELAKKSKIWFIFSENVKIGGIESLINNFLQKYDLHVKVVSFEYEDKFIEHGKTSEVEKNLEKDVNSLLTKVLKFYH
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: 5HT5B_MOUSE
Sequence: MEVSNLSGATPGLAFPPGPESCSDSPSSGRSMGSTPGGLILPGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAVLVMPLSLVSELSAGRRWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRSRASALMIAITWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYLPLAVVLFVYWKIYKAAKFRFGRRRRAVVPLPATTQAKEAPPESEMVFTARRRATVTFQTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELISPLCACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR
What is the function of this protein?
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.  The activity of this receptor is mediated by G proteins.  Probably involved in anxiety and depression.
What are the official names of this protein?
5-hydroxytryptamine receptor 5B, 5-HT-5B, 5-HT5B, Serotonin receptor 5B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIUH_HALH5
Sequence: MSGKVTTHVLDTSCGKPAAGVVVELWRIVEGGESELLTKAVTNQDGRLDKPLLTENKMARGVYELRFQVGDYFLRNGFVNQAYPFLHVIPVRFGLEDVNEHYHVPLLVAPGGYSTYRGS
What is the function of this protein?
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
What are the official names of this protein?
5-hydroxyisourate hydrolase, HIU hydrolase, HIUHase.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
Protein: DNAA_SHELP
Sequence: MAVSLWQQCIGRLQDELSAQQFSMWIRPLQAEMDGETLVLYAPNRFVLDWVRDKYLNTINQFFTEQMGSDAPKLRFDIGSRPASKPAAPAASTKSPVAPAAKSPSKPSFNSNEPAATANHRSNMNPTYQFDNFVEGKSNQLGKAAALQVSENPGGAYNPLFLYGGTGLGKTHLLHAVGNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDRSQEEFFHTFNALLEGNHQVILTSDRYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKAQESGINLPDEVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARPRQMAMALSKELTNQSLPEIGDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBF_IPOBA
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVFFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: VPC23_MYCTU
Sequence: MIFVDTNVFMYAVGRDHPLRMPAREFLEHSLEHQDRLVTSAEAMQELLNAYVPVGRNSTLDSALTLVRALTEIWPVEAADVAHARTLHHRHPGLGARDLLHLACCQRRGVTRIKTFDHTLASAFRS
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.  The cognate antitoxin is VapB23 (By similarity).
What are the official names of this protein?
Ribonuclease VapC23, RNase VapC23, Toxin VapC23.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: OBG_PHYAS
Sequence: MFSLHFIDEAFNEVYAGNGGHGIVAFRREKYVPFGGPAGGNGGNGGSVIFVGEQGETTLLKLKYQKHLKASHGFNGKNKSQNGANAPHLYVKVPLGTVFFTMDNHFLGEILHHQETLVIAKGGKGGRGNKALANFKNPAPSYAEKGDLGEHFKIKIQLKVLADVGLLGFPSVGKSSLISLISKAQPKIDSYPFTTLFPHLGVVLIDGFSFVIADLPGLIPNAHLGQGLGIQFLKHIERCRVLVHLISMQSLDPYKDYVALNKELQQYNSTLVEKKQIIVANKMDLPDAEKKLKDLQKKLSDVTIIPLSLINFYNIEKLKYAIKNLLQKTPFVIPKHDNFKVYDLNSETQTFTINKNKEGVFVVSGRQVEIFSHRTDFNNEAAVKRFNYLLKKIGIEEALKQKGAKLGDQVKICNYLFDFVI
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR_STRPI
Sequence: MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAYGHGAVAVAKAIQDDVDGFCVSNIDEAIELRQAGLSKPILILGVSEIEAVALAKEYDFTLTVAGLEWIQALLDKEVDLTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVRVEGIFTHFATADEESDDYFNAQLERFKTILASMKCLPELVHASNSATTLWHVETIFNAVRMGDAMYGLNPSGAVLDLPYDLIPALTLESALVHVKTVPAGACMGYGATYQADSEQVIATVPIGYADGWTRDMQNFSVLVDGQACPIVGRVSMDQITIRLPKPYPLGTKVTLIGSNGDKEITATQVATYRVTINYEVVCLLSDRIPREYY
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: UVRC_METMP
Sequence: MINISDIPKNPGCYIYKNESGTVIYVGKAKNLKKRVSSYFNKKNHDPKTEKLVKSIYEMEFIVTDNEVEALILENTLIKKYSPKYNIDLKDSKNYAYIYISEENFPRIGISRNKSKKGKFYGPFTSAKERDYVLDVLKKTFKIRSCKNMHKRPCLRHHIKNCTAPCSGDITSKDYLNQIKKAEHILKGNIDSLIHELKNEMNEKSKNLQFEEALLIREEINAIERLKTRQNVKRDVKYNEDVISILEKSGKLHIMVFNVLKGTLFDRKYFEFDYTENFFEEFLIQYYSENDVPSEIIISELPKNLEEDNNEYSSDALLEYLSKKKGSKVAFKIPKQGEKKQLLDLAIKNLEIYVNGNEIKVQSLKNKLMLDKSPNIIECFDISHLSGTSTVGSVVQFRNGKPDKKNYRRFKIKTVSGIDDFKSISEVVFRRYSKLLEENLELPDLIIIDGGKGQLSSAFSELRKLKLKIPLISIAKREEEIYTPGIENPLPIKKNEKASLFIQEIRDEAHRFAINYNRLLRKKELIK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCD_AQUAE
Sequence: MAILVNKDTKVVVQGITGKEGSFHAKQCKEYGTQVVAGVTPGKGGMEVEGIPVFNTVKEAVKETGANCSLIFVPAPFAADAIVEALDAGIELVVCITEGIPVKDMMMVKDYMLKNYPNAKLVGPNCPGVITPGEAKVGIMPGHIFKRGKIGIVSRSGTLTYEAAYQLTKYGLGQSTAVGIGGDPVHGLTHRDVIEMFNKDPETEAILMIGEIGGTEEEEAAEYIEKEVDKPVFAYIAGITAPPGKRMGHAGAIIMGGKGTAKAKMEALEKAGAYVIENPAKIGETVAKILKVIELEEEERTSDAE
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit alpha, Succinyl-CoA synthetase subunit alpha, SCS-alpha.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase alpha subunit family.
Protein: UPPP2_BACHK
Sequence: MEQFYYILKYLILGLFQGLTEPIPISSSGHLVLAQHLLGLKIEGFSFELLVNSASLLAVLLIYRNDLIRLTKNGLSYIFTRAEDAKSDFFFIIYLVIATIPAGVIGVLFKDYIDQYLKGVKMVGISLLITAVGLWIIRNLRGRKNDGDLSMKDAIIVGLAQACALIPGISRSGATIVAAMLLGMKQETALRFSFLLYIPVSLGGLLLSITDIAKDPNLDTLFVPYIVAFIATFIMTYISLKWFMNIMAKGNLKYFSFYCIIVGVLTLIFL
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 2, Bacitracin resistance protein 2, Undecaprenyl pyrophosphate phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRUA_THEP1
Sequence: MKRVAAVIEYDGSNFFGYQGQPDVRTVQGVIEDALERIFKQRIYIQAAGRTDTGVHANGQLIAFNCPNDRMTTEDIRNAMNANLPDDVYVKEVFEVPVNFHPRFDVTKRIYHYFILTSRQKNVFLRKYVWWFPYELDLDAMRKAVKYLEGTHDFTSFKTGSDERDPVRTIYRIRILRLKNDLVLIRVEGRSFLRRMVRNIVAALVKVGLKQWEPEKMKEVLEARDRSAAAGTAPAHGLYFYKVLF
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: LRC69_MOUSE
Sequence: MAERLLVTALKGGKNTKILTLNGKRITKMPSTLEKLPNLKTLDLQNNSISKVCPELRTLTQLTLLNLGNNHLQEVPEEIKYLTSLKNLHLFGNRICRIAPGVFNGLHRLIMLNLNDNRLTSLPQEIGRLRSLTYLSLNRNNLTVIPKELCSLEHLSELHLNYNQIVYIPEEIKFLKNLQQLFLVRNNIEELPEEICHLEKLRVLDIAGNVIQIFPAGFQNLRLTEFYCEGNPLFLKRPFFAVQPKDLWTLREIAARFVLSLLEENDPLIMNVIESYPEVKDKLSKAKKCSICRKPFLTEWLECVYFVAPSKNWKISRNLKLIPVQTSVCSYQCFDQRDPDVFGIAQE
What are the official names of this protein?
Leucine-rich repeat-containing protein 69.
What is the protein family that this protein belongs to?
Belongs to the LRRC69 family.
Protein: FKBP5_PONAB
Sequence: MTTDEGAKNNGESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHVIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYSKLREYTKAVECCDKALGLDSANGKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV
What is the function of this protein?
Immunophilin protein with PPIase and co-chaperone activities.  Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90).  Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.  Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1.  Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP5, PPIase FKBP5, FK506-binding protein 5, FKBP-5, Rotamase.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RFAF_HAEIN
Sequence: MNILIIGPSWVGDMMMSHSLYQQLKIQYPNCNIDVMAPNWCKPLLARMPEVRKAIEMPLGHGAFELGTRYRLGKSLREQYDMAIVLPNSLKSAFIPFFAKIVHRRGWKGESRYILLNDLRANKKDYPMMVQRYVALAFEKDVIPKADDIPVLKPYLTVEPAQQAETLKKFEKQTALLGERPIIGFCPGAEFGPAKRWPHYHYAKLAEMLITQGYAVALFGSAKDEPVGEEIRQALPEELREFCVNLAGKTNLNEAVDLIANCTAVVTNDSGLMHIAAAVNRPLIALYGPTSPQYTPPLSDKATIIRLIEGELIKVRKGDKEGGYHQSLIDITPEMALEKLNELLAK
What are the official names of this protein?
ADP-heptose--LPS heptosyltransferase 2, ADP-heptose--LPS heptosyltransferase II.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 9 family.
Protein: NQRD_YERPB
Sequence: MADSKEIKRVLLSPLFDNNPIALQILGVCSALAVTTKLETALVMTLAVTLVTAFSSFFISLIRNHIPNSVRIIVQMVIIASLVIVVDQVLRAYAYEISKQLSVFVGLIITNCIVMGRAEAYAMKSPPIESFMDGIGNGLGYGVILVLVGFVRELVGSGKLFGVTVLETVQNGGWYLPNGLFLLAPSAFFIIGLLIWGLRTLKPAQIEKE
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL27_ALISL
Sequence: MAHKKAGGSTRNGRDSESKRLGVKRFGGESVLAGNIIVRQRGTKFHAGTNVGIGKDHTLFALSEGKVKFEVKGPKNRKFVSIDAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SYL_SHESR
Sequence: MQEQYNPSEIEALVQKHWHDNKTFEVTEDANKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVVARFQRLQGKNVLQPIGWDSFGLPAENAAINNKTAPAPWTYQNIEYMKNQLKLLGFGYDWSREIATCTPEYYRWEQWFFTKLYEKGLVYKKTASVNWCPNDETVLANEQVQDGCCWRCDTPVEQKEIPQWFIKITAYAEELLNDIDTLDGWPEQVKTMQRNWIGRSEGVEMTFGVAGSDKSFDIYTTRPDTLMGVTYVAIAAGHPLAELAAQSNPELAQFIEECKNSTTSEADLATMEKRGVATGLYAIHPISGKQVPIWAANFVLMNYGTGAVMSVPGHDQRDYEFAKKYNLPIEAVIKPVDGELDISEAAYTEKGVLFNSGEFDGLDFDGAFNAIADKLVAEGKGKRQVNYRLRDWGVSRQRYWGAPIPMVTLADGTVIPTPEDQLPVILPEDVVMDGIQSPIKADKEWAKTQVNGQDALRETDTFDTFMESSWYYARYCSPQADQMLDPTKANYWLPVDQYIGGIEHACMHLLYFRFFHKLLRDAGLVNSNEPAKQLLTQGMVLADAFYYTNDKGARVWVSPLDVVTTEKDDKGRVTKAIDKDGNELVYTGMCKMSKSKNNGIDPQVMVEKYGADTVRLFMMFASPPELTLEWQESGVEGAHRFIKRLWKLASDYVAQDNSEALDVSKLTSEQKALRREVHKTIAKVTDDIGRRQMFNTAVAAVMELMNHLQKAPQTTGQDRAIIGEALTAVVRLLYPIIPHVSFTLWNELGNTNSIEDSQWPVVDESALVEDSKLIVVQVNGKVRAKITVAADADQASVEALGMADEQVIKYLDGVTVRKVIYVPGKLLSIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_SHEPW
Sequence: MANKTVLFNKHLESNGKMVDFHGWDMPLNYGSQIEEHHAVRQDAGMFDVSHMTVVDVIGDDACAFLRKLLANDVAKLKVPGKALYGGMLDHNGGVIDDLITYYLSDTQYRIVVNSATREKDLAWINEQVKGFSVEVTERPELAMIAVQGPNAKAKAATVFNDTQNAAVEGMKPFFGVQADSLFIATTGYTGETGYEVIVPEAEAEALWQAFLDAGVKPCGLGARDTLRLEAGMNLYGLDMDESVNPLAANMGWTVAWAPEDRDFNGRKALEKIKAEGADKLVGLIMDAKGVIRHGMSVFFTDSDGVEQQGTITSGTFSPTLGYSIAMARVPNTIGDVAEVEMRKKRVPVKVIAPSFVRNGKQAF
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: Y898_FRATT
Sequence: MQTIEIGNKAELQACKFLHTQALEILAHNFKALPYGEIDIIALDKDTLIFIEVKYRSKTKFAQAEEMLTYSKQQKLVNSASIYLQHNPQYQDYQCRFDLIAINESNINWIKNAFGVI
What are the official names of this protein?
UPF0102 protein FTT_0898c.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: DTD_YERPY
Sequence: MIALIQRALSASVVVEGNIVGEIGPGLLVLLGVEQGDTEQKAQRLCERVLGYRIFSDENDKMNLNVQQAGGSVLVVSQFTLVADTQKGMRPSFSRGAIPQEADRLYQYFVAQCRERGVKTETGLFAADMKVSLVNDGPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS24_METVS
Sequence: MDIKIISDKNNPLLHRREVKFLATFDGATPSIKDVKVKLVAILNAKKEMLVIDTLDQEFGKLEAKGYAKIYEDEKIMNTVEKKSVLEKNKLEEAAEVAEE
What are the official names of this protein?
30S ribosomal protein S24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: FZD6_CHICK
Sequence: FGFAWPEELECSRLVNCDETAPATAPVTTNAHGTQKTPGQTRRDYGFWCPRHLHTSNGQGYKFLGIDQCAPPCPNMYFKNYELDVAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVSLMYFIGFLLGNRTACNKADDKLEIGETVVLGSQNKACTVLFMVLYFFTMAGTIWWVI
What is the function of this protein?
Receptor for Wnt proteins.  Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism.  Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  Together with FZD3, may be involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).
What are the official names of this protein?
Frizzled-6, Fz-6, cFz-6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell surface. Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: HCN1_SCHPO
Sequence: MLRRNPTAIQITAEDVLAYDEEKLRQTLDSESTTEEALQKNEESTRLSPEKKKIIRERRIGITQIFDSSMHPSQGGAAQS
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.  Has a role in assembling cut9 in the 20S APC/cyclosome.
What are the official names of this protein?
Anaphase-promoting complex subunit hcn1, 20S cyclosome/APC complex protein hcn1, Chaperone-like protein hcn1, High copy suppressor of cut9 protein 1.
Protein: MURA2_LISMO
Sequence: MTDRLIIQGGKKLSGTLQVDGAKNSAVALIPAAILAESEVVLEGLPDISDVYTLYDILEELGGSVRYDNKTAIIDPTDMLSMPLPSGNVKKLRASYYLMGAMLGRFKKAVIGLPGGCYLGPRPIDQHIKGFEALGAKVTNEQGAIYLRADELKGARIYLDVVSVGATINIMLAAVRAKGKTVIENAAKEPEIIDVATLLTNMGAIIKGAGTDTIRITGVDHLHGCHHTIIPDRIEAGTFMVLAAASGKGIRIENVIPTHLEGIIAKLTEMGVPMDIEEDSIFIGEVENIKKVDIKTYAYPGFPTDLQQPLTALLTRAEGSSVITDTIYPSRFKHIAELERMGGKFKLEGRSAVISGPAKLQGSKVTATDLRAGAALVIAGLLAEGRTEIHGVEHIERGYSKIIEKLSAIGADITRSSTAETNI
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2, Enoylpyruvate transferase 2, UDP-N-acetylglucosamine enolpyruvyl transferase 2, EPT 2.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_BUCAI
Sequence: MKKKNIKNSMNNHTPMIKQYLSLKSQYPDMLLFYQMGDFYELFYEDAERISELLKITLTKKGYSNHKIIPMAGVPCHKSEYYLSKLVKLGESIAICDQQKETDCKKKLISRKVVRIITPGTVTDEVLLEENEDNFIAAIWKENNQFGYSVLDLSLGFFGVSKIFSSCDLLSEIERTNPKEILYPENFSDVFLIESRKCIRKRSLLEFDLETSYKLLNLQYNTCSLDGFGIEKNNFVIRAAGCLLQYVKSMNMTLLPNIRQLKYNYMEDSIFMNFSTRKSLEITQNISGEKKNTLSAILNKTVTSMGSRMLNRWLNSPLKNFKIVRNRHESVEALQFFYKELQFILRQVNDLERIYSRLALRTASPHDFVRMRSTLEILPNLHLILKKIKSKHIKKIRLSIGYFEEVLCLLKKAISLKPSKCIRDGGVIAELYNIELDELRSIKINSKEYIKNFEQKEKKKLMIESFKIKFNKIIGYYIQISKRHTHLIPKYYVIIQTLKNTERYSVPLLKEYEEKVLNSEMRSLLLEKKLYAEIFNIIEPFLEKLQNSALALSELDVLVNLSERAISLNYTRPIMSEKYGISLLESRHPVVECFLKTPFIKNSVFLSRTQRMIIITGPNMGGKSTYMRQIALIVIMAGIGSFVPARYALIGSIDKIFTRIGSADDLSNGYSTFMMEMMEISNILHNATSNSLVLIDELGRGTSTNEGLSLAWSCSRYLININKSMTLLSTHFVELTKLEEKEKFVKNFHFSAIKSDLHIAFLYKIKNGISKKSYGISVASLSGLPDSVLEDAEKKLIEIENT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: ENO_STRPB
Sequence: MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYLGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMITLDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYTYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIMPVGAPTFKEGLRWGAEVFHALKKILKERGLVTAVGDEGGFAPKFEGTEDGVETILKAIEAAGYEAGENGIMIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQVDYLEELVNKYPIITIEDGMDENDWDGWKVLTERLGKRVQLVGDDFFVTNTEYLARGIKENAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNLKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.