PharMolix/UniProtQA huggingface dataset:
Protein: SYM_SALTI
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSDENRELSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSADQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTTSFDEYWKKDSDAELYHFIGKDIVYFHSLFWPAMLEGSHFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLKHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLAAELADPQLYKTFTDAAAVIGEAWESREFGKAIREIMALADVANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPTLSERVEAFLNSELNWDAIEQPLLSHKVNTFKALYNRIDMKQVEALVEASKEEVKAAAAPVTGPLADFPIQETITFDDFAKIDLRVALIENAEFVDGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRQTVMVANLAPRKMRFGVSEGMVMAAGPGGKDIFLLSPDDGAKPGQQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSSA_MOUSE
Sequence: MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTAAQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTEWS
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.  Also functions as a cell surface receptor for laminin.  Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways.  May play a role in cell fate determination and tissue morphogenesis.  Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.  Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity).  Enables malignant tumor cells to penetrate laminin tissue and vessel barriers.  Activates precursor thymic anti-OFA/iLRP specific cytotoxic T-cell.  May induce CD8 T-suppressor cells secreting IL-10.
What are the official names of this protein?
40S ribosomal protein SA, 37 kDa laminin receptor precursor, 37LRP, 37 kDa oncofetal antigen, 37/67 kDa laminin receptor, LRP/LR, 67 kDa laminin receptor, 67LR, Laminin receptor 1, LamR, Laminin-binding protein precursor p40, LBP/p40, OFA/iLRP.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Colocalizes with PPP1R16B in the cell membrane (By similarity). 37LRP shuttles to the nucleus upon midkine (MDK) binding.
Protein: SIGIR_HUMAN
Sequence: MPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDKDPMLILRGRVPEGRALDSEVDPDPEGDLGVRGPVFGEPSAPPHTSGVSLGESRSSEVDVSDLGSRNYSARTDFYCLVSKDDM
What is the function of this protein?
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways.  Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4.  Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
What are the official names of this protein?
Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, TIR8.
What is the protein family that this protein belongs to?
Belongs to the interleukin-1 receptor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type III membrane protein.
Protein: ATN1_HUMAN
Sequence: MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL
What is the function of this protein?
Transcriptional corepressor.  Recruits NR2E1 to repress transcription.  Promotes vascular smooth cell (VSMC) migration and orientation (By similarity).  Corepressor of MTG8 transcriptional repression.  Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
What are the official names of this protein?
Atrophin-1, Dentatorubral-pallidoluysian atrophy protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Cell junction. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell- cell junctions and leading edges of cells (By similarity). Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Gln (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles.
Protein: GYL1_YEAST
Sequence: MNSNEDIHEERIEVPRTPHQTQPEKDSDRIALRDEISVPEGDEKAYSDEKVEMATTNASSNFGSNESAKDGESIGAFSNPHEALMQSKLREESQSKTILPSDDLSQQLETEESKVEEALKRITSPPLPPRADCIEESASALKSSLPPVLAGNKNDQAPLDRPQLPPRQVVNAETLHLKAPHGNATPSKSPTSAVGNSSSSTPPTLPPRRIEDPLDLAAQKHFLASTFKRNMLFYKSEDNSIKCDLDKNILNLKEDSKKINNNEIPEEVSSFWLKVIGDYQNILINDIETLHFQLSRGIPAAYRLVVWQLVSYAKSKSFDPIYETYLTEMAPFDVQEFENQLKMMDEVPSEYVKRISNVLKAYLLFDPECEFSTDIAYIINMILDVCEEEANAFGLLVRLMKVYGLRLLFLPSASEIDILCYKFDRLVEEFYPEIHNHMVEKGVRSSMFLPGFFTTLFQKKLPTEIQPRIGDMVFLEGIDSIMRILATLLSNSRDHLLKMGFDDMLELLKSGLLDAYIKQNDGTRGDTLLSNECMDKLLQDSMMKVAITPKTMKKYSSEYEEIHRLDNEKEVQYKSITEKNLHLQKHVRKLENDYTSLNREHVTIANELVKNRLNIESVLNENNGYKLQILDLKKKLDSEKKKQVLGVYVPNDLKKDLEETMKKNTQVMDENLKLQDRISELERLIEEIKTANKNGTLFEYSNSKNNPLGAGWSGFKKVFK
What is the function of this protein?
Probable GTPase-activating protein which stimulates the GTP hydrolysis rate by GYP5 of YPT1 and SEC4.  Involved in ER to Golgi trafficking and polarized exocytosis.
What are the official names of this protein?
Probable GTPase-activating protein GYL1, GYP5-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the GYP5 family.
What are the subcellular locations of this protein?
Cytoplasm. Bud. Bud neck.
Protein: RL35_GEMAT
Sequence: MPKMKTHSGAKKRFSVTGSGKVRRLKAYKSHILTKMSGKKKRDLRRPTIVETNGEAKRIKRLLVA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: UVRC_STRP4
Sequence: MNNLIKSKLELLPTSPGCYIHKDKNGTIIYVGKAKNLRNRVRSYFRGSHDTKTEALVSEIVDFEFIVTESNIEALLLEINLIKENKPKYNIMLKDDKSYPFIKITNERYPRLIITRQVKKDGGLYFGPYPDVGAANEIKRLLDRIFPFRKCTNPPSKVCFYYHIGQCMAHTICKKDEAYFKSMAQEVSDFLKGQDNKIIDELKGKMAAAAQTMEFERAAEYRDLIQAIGTLRTKQRVMAKDLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNLFPYFNDPDEDFLTYVGQFYQEKSHLVPNEVLIPQDIDEEAVKALVDSKILKPQRGEKKQLVNLAIKNARVSLEQKFNLLEKSVEKTQGAIENLGRLLQIPTPVRIESFDNSNIMGTSPVSAMVVFVNGKPSKKDYRKYKIKTVVGPDDYASMREVIRRRYGRVQREALTPPDLIVIDGGQGQVNIAKQVIQEELGLDIPIAGLQKNDKHQTHELLFGDPLEVVDLSRNSQEFFLLQRIQDEVHRFAITFHRQLRSKNSFSSQLDGIDGLGPKRKQNLMRHFKSLTKIKEASVDEIVEVGVPRAVAEAVQTKLNPQETEILLQVAEERVDYQTEGNHNKP
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_COREF
Sequence: MSEANVSNKEKGARKVRTGYVVSDKMQKTIVVELEDRKQHALYSKILRTNKKVKAHDEENIAGIGDLVRIEETRPLSKDKNYRLIEIIEKAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: SYGB_STRA3
Sequence: MTKDLLLELGLEELPAYVVTPSEKQLGQKMVKFLEDHRLSFETVQTFSTPRRLAVRVKGLADQQTDLTEDFKGPSKKIALDAEGNFSKAAQGFVRGKGLSVDDIEFREVKGEEYVYVTKHETGKSAIDVLASVTEVLTELTFPVNMHWANNSFEYIRPVHTLVVLLDDQALELDFLDIHSGRISRGHRFLGSDTEILSASSYEDDLRQQFVIADAKERQQMIVDQIHAIEEKENISVEIDEDLLNEVLNLVEYPTAFLGSFDEKYLDVPEEVLVTSMKNHQRYFVVRDRDGKLLPNFISVRNGNAEHIENVIKGNEKVLVARLEDGEFFWQEDQKLNIADLVEKLKQVTFHEKIGSLYEHMDRVKVISQYLAEKADLSDEEKLAVLRAASIYKFDLLTGMVDEFDELQGIMGEKYALLAGEQPAVAAAIREHYMPTSADGELPETRVGAILALADKFDTLLSFFSVGLIPSGSNDPYALRRATQGIVRILEAFGWDIPLDELVTNLYGLSFASLDYANQKEVMAFISARIEKMIGSKVPKDIREAVLESDTYIVSLILEASQALVQKSKDAQYKVSIESLSRAFNLAEKVTHSVSVDYSLFENNQEKALYQAILSLELTEDMHDNLDKLFALSPIINDFFDNTMVMTDDEKMKQNRLALLNSLVAKARTVAAFNLLNTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBI_HELAN
Sequence: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGREE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: IF2P_SULAC
Sequence: MTTQVPKRLRQPIVVVLGHVDHGKTTLLDKIRGTAVVKKEPGEMTQEVGASFVPTSVIEKISEPLKKSFPIKLEIPGLLFIDTPGHELFSNLRKRGGSVADIAILVVDIVEGIQKQTLESIEILKSRKVPFIVAANKIDRINGWKAQDTYSFLESINKQEQRVRDNLDKQVYNLVIQLAEQGFNAERFDRIRDFTKTVAIIPVSAKTGEGIAEVLAILAGLTQNYMKNKLKFAEGPAKGVILEVKELQGLGYTADVVIYEGILRKNDIIVLAGIDGPIVTKVRAILVPRPLQDIKLAKSDLAQIDEVYAASGVKVYAQNLETALAGSPIYVAENNEEVEKYKKIIQEEVSAVRYYNSSVYGIIVKADSLGSLEAIVSSLERRNIPIRLADIGPISKRDITEAEIVAEKAKEYGIIAAFRVKPLSGIEIPEKIKLISDDIIYQLMDNIEKYIEDIKESEKRKTLETIVLPGKIKIIPGYVFRRSDPVIVGVEVLGGIIRPKYGLIKKDGRRVGEVLQIQDNKKSVDRASKGMEVAVSIKGNIMVGRQVEEGEVLYTDVPKEDLQILMEKYKDIVTDDMIEVIKEIIRIKRTQDATYGLGLQFQ
What is the function of this protein?
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes.  Seems to function along with eIF-2 (By similarity).
What are the official names of this protein?
Probable translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Protein: FEN1_USTMA
Sequence: MGIKGLTALISDEAPGAIKEMEIKTYFGRKVAIDASMSLYQFLIAVRQNDGQQLMTESGETTSHLLGFFYRTLRMIDYGIKPMYVFDGTPPDLKKELLQKRFGRREEAREQEEEQKDVADAEKMDQLARRQVRPTRQHNEEVRHLLKLMGIPCVIAPSEAEAQCAELARAGKVYAAGSEDMDTLTFGTPILLKHLTASEQKKLPVHQVDLAKALEGLQMTMAQFIDLCILLGCDYLDPIKGIGPKTALKLIREHKTLENVVHHLKEDGKKSVQIPDHWPFQEARKIFESPDVQKGVDLDLKWEAPDVEAMVKFLCQDKGFSEDRVRKGCEKLQKSLSQKQQGRLDGFFTVKPGSAPPKRKAEDDKKNVKKKGKK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: Y144_PROMA
Sequence: MYLIELALKLSPLPLSVQRKKLEDAKALYNQLKESLKKGDPRLLEISCEQVEDKKIAVLVSEVLAVQMYEKTAGAGGNRRPGFSFDE
What are the official names of this protein?
UPF0367 protein Pro_0144.
What is the protein family that this protein belongs to?
Belongs to the UPF0367 family.
Protein: PQQC_ACICA
Sequence: MTQTPEALTTEQFKQAIIDKGQYYHIYHPFHVMMYEGKATQQQIQAWVANRYYYQINIPLKDAAIMANCPDQRVRQEWIQRMIDQDGEYPDGGGREAWLRLAEAVGLSREQVISEELVLPGVRFAVDAYVNFRRRASWREAASSSLTELFAPQIHQSRLDSWPQHYPWIDDKGYEYFRSRLSQARRDVEHGLTITLDSFTTFEQQERMLEILQFKLDILWSILDALTLAYVHNEAPYHSVTSKRVWHKGLFK
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Coenzyme PQQ synthesis protein I, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: GAT26_ARATH
Sequence: MGKQGPCYHCGVTNTPLWRNGPPEKPVLCNACGSRWRTKGTLVNYTPLHARADGDENDDHHRFQRMKSISLGNKNKEIKMLKRKAIQENIIIKRPVFEFSYGLKAAVIEEDASNRSSSGSAVSNSESCAQFSSADGSPSQSNAWDTTVPCKRRTCVGRPKSSSVEKLTKDLYNILQEQQSSCLSVSSEEDLLFENEMSMVSVEIGHGSVLMKNPHSFAREEESEASSLSSIENKSSISDAYSHSVKRVEIGAVRGSYYGGQTIKQEQFKRTKSQTERVHVLGSHGSPLCSIDLKDVFNFDEFIEQFTEEEQKKLMNLLPQIDSDDLPHSLRMMFESAQFKDNFSLFQQLIADGVFDVSSSSGAKLEEIRTFKKLALTDFNKSRLVESYNLLKEREKGTGDSVTTTSKSSIPNVPKNIVTIKRRYENQIQVKSESRGLMRSPKRVMKMKASHETENNVSCFRPRSLASVFAQEGGSAVFSYEGNCSSDQDLLLLDLPSNGSFPQAELLHQL
What is the function of this protein?
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
What are the official names of this protein?
GATA transcription factor 26.
What is the protein family that this protein belongs to?
Belongs to the type IV zinc-finger family. Class D subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROS_BOVIN
Sequence: MSAALLRRGLELLGAPEAPGAAPGHTKPSQAPMKRTRKAKATQAQKLRNSAKGKVPKSALAEFRKKERRGYLGVNLRFMTSARSTVDESVTRQIMRQNRGRKACDRPVTKTKKKKKAEGTVFTEEDFQKFQREYFGS
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1.  Direct regulator of SIRT1.  Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.
What are the official names of this protein?
Active regulator of SIRT1, 40S ribosomal protein S19-binding protein 1, RPS19-binding protein 1, S19BP.
What is the protein family that this protein belongs to?
Belongs to the AROS family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RRP41_HYPBU
Sequence: MAGGAGEKPTLIRWEERDGQKVAIRHDGRLPEQLRPIRMEVGVLSNADGSALVEYGGTRVIAAVYGPREAHPRHVALPDRAIIRCRYHMAPFSTAERKTPAPTRREVELSKVIREALEAVVISELYPRTAIDVYMEVLQSDGGTRTAAITAASLALADAGIAMRDLVAGVAVGKVDGVLVLDIDEIEDNYAEADMPVAMAPSLDKVLLLQLNGVLTHDEFVKALELARKGIQVIYNLQKEALRKKYVEVSVEEGA
What is the function of this protein?
Catalytic component of the exosome, which is a complex involved in RNA degradation.  Has 3'->5' exoribonuclease activity.  Can also synthesize heteromeric RNA-tails.
What are the official names of this protein?
Exosome complex component Rrp41.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family. Rrp41 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CND2_SCHPO
Sequence: MKRASLGGHAPVSLPSLNDDALEKKRAKENSRKQRELRRSSALHSITPRRESLNNSSPFNSSHQVPVLSNFEEWIKLATDNKINSTNTWNFALIDYFHDMSLLRDGEDINFQKASCTLDGCVKIYTSRIDSVATETGKLLSGLANDSKVLQQTEEGEDAENDDEDLQKKKERKRAQRSVKTLVKDFESIRAKKFELECSFDPLFKKMCADFDEDGAKGLLMNHLCVDQHGRIVFDSSDTVIKDLENKDVEAESQEAVVAAPIESHDTEMTNVHDNISRETLNGIYKCYFTDIDQLTICPSLQGFEFDSKGNLDVSLLKSLSDEVNMITTTSLVDNTMEKTDADAASLSSDSDGEEGHIVHALEEMAYDEENPYVDVVPKAMDESENPDFGVDTEVNMADGSTMNENYSIISTAAANGVYEYFDKSMKKNWAGPEHWRIQALRKNINNASTVFNSSNTAESSDNVSRSLSSTERKKRRELDNAIDFLQEVDVEALFTPATSSLKLPKSHWKRHNRCLLPDDYQYDSKRLLQLFLKPKMSVLPNADGEGQLQLNKALDDENDLDGIQPHGFDSDGSDNVDEGIPPYGFGDSDSPKQTPLLTPPSSSGFGDNLLLTARLAKPDMLNYAKRAKKVDVRVLKEKLWKCLDLENTIKENSINSHIEGSEMESEETNMPVKSFFSTVNQLEETYEKKELKDISTSFAFICVLHLANEHNLELTSNEDFSDVFIRPGPNLTTLEALENDV
What is the function of this protein?
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.  The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.  The condensin complex probably also plays a role during interphase in processes such as DNA repair.
What are the official names of this protein?
Condensin complex subunit 2, Barren homolog, CAPH homolog, p105.
What is the protein family that this protein belongs to?
Belongs to the CND2 (condensin subunit 2) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Protein: RPOB_BRUSU
Sequence: MAQTHSFNGRKRVRKFFGKIPEVAEMPNLIEVQKASYDQFLMVEEPSGGRPDEGLQAVFKSVFPIQDFSGASMLEFVRYEFDPPKFDVDECRQRDLTYSAPLKVTLRLIVFDIDEDTGAKSIKDIKEQDVYMGDMPLMTDNGTFIVNGTERVIVSQMHRSPGVFFDHDKGKTHSSGKLLFAARVIPYRGSWLDIEFDSKDIVYARIDRRRKLPATTLLMALGMDGEEILSTFYKTVTYTRDGDNWRIPYSAERFKGMKIISDLVDADTGEAVLEAGKKLTARAAKQLAEKGLKAIKATEDDLFGSYLAEDVVNYATGEIYLEAGDEIDEKVLKTLIDTGETEINVLDIDHVNIGAYIRNTLAVDKNESRQEALFDIYRVMRPGEPPTMDSAEAMFHSLFFDSERYDLSAVGRVKMNMRLDLDAEDTVRVLRKEDILAVVKMLVELRDGRGEIDDIDNLGNRRVRSVGELMENQYRVGLLRMERAIKERMSSIEIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATFARVNKYGFIESPYRKVVDGKVTNDVVYLSAMEEAKHSVAQANVELDEQGGFVDEFVICRHAGEVMMAPRENVDLMDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVRAEAPFVGTGMEPIVARDSGAAIAARRGGIVDQVDATRIVIRATEELDPSKSGVDIYRLQKFQRSNQSTCINQRPLVRVGDRIHKGDIIADGPSTDLGDLALGRNVLVAFMPWNGYNYEDSILLSEKIVSDDVFTSIHIEEFEVAARDTKLGPEEITRDIPNVSEEALKNLDEAGIVYIGAEVHPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSMRMPPGTYGTVVEVRVFNRHGVEKDERAMAIEREEIERLAKDRDDEQAILDRNVYGRLADMIDGKVAAAGPKGFKKGTTITRELMTEYPRSQWWQFAVEDEKLQGELEALRSQYDDSKKLLEARFMDKVEKVQRGDEMPPGVMKMVKVFVAVKRKIQPGDKMAGRHGNKGVVSRILPVEDMPFLEDGTHADIVLNPLGVPSRMNVGQILETHLGWACAGMGKKIGELLDVYRKTANIEPLRQTLEHIYPDNDRNEPVRSYDDDAILMLANQVKRGVSIATPVFDGAVEADINAMLTDAGLATSGQSTLYDGRTGEPFDRQVTMGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYEAIVRGDDTFEAGIPESFNVLVKEMRSLGLNVELDDTREAEQPALPDAAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CYB_VIRLA
Sequence: MALNLRKNHPLMKIVNDSLIDLPTPSNISAWWNFGSLLGICLITQIVTGLLLAMHYTADTSLAFASVAHTCRNVQFGWLIRNLHANGASFFFICIYLHIGRGLYYGSYLNKETWNVGIILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFVIAGLTLVHLTFLHETGSNNPLGIPSDCDKIPFHPYYTIKDILGFALMLSSLVALALFSPNLLGDPENFTPANPLATPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASILVLFLMPLLHTSKQRSMTFRPLSQILFWVLVANLLILTWIGSQPVEQPFIIIGQLASLSYFTIILVLFPIAGVLENKLLKL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VKT25_CYRHA
Sequence: IDTCRLPSDRGRCKASFERWYFNGRTCAKFIYG
What is the function of this protein?
Serine protease inhibitor that inhibits trypsin and blocks voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type serine protease inhibitor hainantoxin F7-25.66, Peptide F7-25.66.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 02 (native) subfamily.
What are the subcellular locations of this protein?
Secreted.