PharMolix/UniProtQA huggingface dataset:
Protein: AL3A2_HUMAN
Sequence: MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY
What is the function of this protein?
Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids.  Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499).  Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490).
What are the official names of this protein?
Aldehyde dehydrogenase family 3 member A2, Aldehyde dehydrogenase 10, Fatty aldehyde dehydrogenase, Microsomal aldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: MACB_SHESW
Sequence: MSAALLEISGCYRTFQAGEQQLTVLKDVNLTIERGEMVAIVGASGSGKSTLMNILGCLDKPSKGAYFINGQDTSTMDADELAQLRREHFGFIFQRYHLLSDLTAIGNVEVPAVYAGKERSARKDRAEHLLTRLGLGDRLDHKPNQLSGGQQQRVSVARALMNGGDVILADEPTGALDSHSGEEMMQLLQELHSDGHTIIIVTHDMNVAQYADRIIEIKDGIIISDERKTKAPKHVDTAVTKINNRIRVASWDRYVEAFKMALLAMSTHRLRTFLTMLGIIIGIASVVSVVALGEGSQREILNSISSMGTNTIDIRPGFGFGDRRSGKVKTLIVKDADALKHLPYVDSVTPTVDSSMTLRYGNKAVTTVVNGVGPEFFRVRGYELAMGQFWDEDSVSSLAQDAVIDDKVRKELFPRSSPIGEVIFIGNLPVRIIGVTEPKDSVFGKSDSLNVWLPYTTLSGRIVGKNYLNGITVRLNESVPSNAAEQGIITLLKMRHGIEDFFTINTDAIRQNIEKTTATMTLLISAIAVISLIVGGIGVMNIMLVSVTERTREIGVRMAVGARQSDILRQFLIEAVLVCLCGGTLGIALAYLIGVVFAQTGGSFQMIYSTTSIVAAFACSTLIGVLFGFLPARNAARLDPVDALARE
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OS9_CANAL
Sequence: MNWTSLVYLWFIFKSIFADLTSHQLKSKVVFLDTTISDEVARSYLGSEDGNVTHGNYEILSIANGANDGNITSYLCQLPRTKKMAPTKPKPTMSVHELKSRAIDLISESFVEGTSCVFSFNLHANYWTIGYCHGINVIQFHENLDDFISGIHKPHSPNHVYTLGNFSKQTSPLEFEFDTKERTISQRLLGEVCDLTGEPRTIDTIYRCDHILEIVELTEIRTCQYELHINVPKLCSLPEFKRTNLEEGVSEILCTRIE
What is the function of this protein?
Lectin involved in the quality control of the secretory pathway.  As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).
What are the official names of this protein?
Protein OS-9 homolog.
What is the protein family that this protein belongs to?
Belongs to the OS-9 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Protein: SELD_PELPD
Sequence: MTDTTIRLTQTVKGAGCAAKLAPGDLDRALCGLDLPVDPNLLVGLERADDAGVYRISDDLALVQTIDFFPPMVDDPYSFGQIAAANALSDIYAMGGVPKTAMNVVAFPAKTMDISVLRSVIEGGLDKMREAGVVLVGGHTVEDSELKYGLSVTGFIHPDRILTKKNLQTGDCLILTKPLGTGIVSTAIKAGLAGSDLTERVIRNMTALNRDAALVMGDFTVHACTDITGFGFLGHLAEMVVDSGCGVRIIAADVPHYPEALEWADMGLIPGGAYNNRDFRGMFVDFGAAVSRRFRDLLFDPQTSGGLLIAVAPNEAEQLVAALKATGIECAAVVGEVVEEPLERIVVE
What is the function of this protein?
Synthesizes selenophosphate from selenide and ATP.
What are the official names of this protein?
Selenide, water dikinase, Selenium donor protein, Selenophosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Protein: ERLN_CAEEL
Sequence: MLTELALGLFALWIAIFSQALHKIEEGHVGVYYRGGALLKAVTNPGYHMHIPFLTTVKSVQVTLQTDEATNVPCGTSGGVLIYFDRIEVVNFLSQDSVYAIVKNYTVDYDRPLIFNKVHHEVNQFCSVHTLQEVYIDLFDKIDEEIKNALQEDLVKMAPGLYVQAVRVTKPKIPEAIRLNYEKMEAEKTKLLVAQETQKVVEKLAETERKKAVIEAEKAAQVALIHQKRLLSEKETEKLLNQMEAESNLASERSKADAEFYKAQKQADSNKILLTKEYLELQKIRAIASNNKIYYGDSIPQAFVMGTTQQTV
What are the official names of this protein?
Erlin, Endoplasmic reticulum lipid raft-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: RIMP_BACCQ
Sequence: MDKKVTEVVEAFAQPIVEELNLELVDVEYVKEGQDWFLRVFIDSEKGVDIEECGAVSERLSEALDKEDPIPHLYFLDVSSPGAERPLKKEKDFQQAVGKQVAIKTYEPIDGEKMFEGKMLSYDGTTITLLLTIKTRKKEIQIPMDKVANARLAVTF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BR22A_ODOHA
Sequence: MFTLKKPLLLLFFLGTISLSLCQEERDADEEEGEMIEEEVKRSLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC
What is the function of this protein?
Has antimicrobial activity against some Gram-positive bacteria and fungi but has no activity against a range of Gram-negative bacteria except P. faecalis.  Has antimicrobial activity against the Gram-positive bacteria S. aureus ATCC 25923 (MIC=19 uM), B. licheniformis X39 (MIC=37. 5 uM) and R. rhodochrous X15 (MIC=9. 5 uM), is virtually inactive against E. faecium 091299 (MIC=150 uM) and S. carnosus KHS (MIC=150 uM) and inactive against E. faecalis 981.  Active against the Gram-negative bacterium P. faecalis X29 (MIC=9. 5 uM) and is inactive against E. coli, P. aeruginosa and S. typhi.  Active against C. albicans ATCC 2002 (MIC=19 uM) and is also active against the slime mold 090223 (MIC=37. 5 uM).  Has extremely low hemolytic activity against human erythrocytes (LC(50)=300 uM).
What are the official names of this protein?
Brevinin-2HS2A.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: Y9851_DICDI
Sequence: MSKLFQDSNKRMSRIVDYDEIKFDPLSIIGSGGFGKVYQGVLNGKEIGIKKITISDNDPNRDILLKFLEREIYTLKMLSHPNVIKFYGIAEKERSLFLLTELVSGGDLHWYIKNKSIDITWKLKVKIARDIAASMAYLHENGVIHRDLKSTNLLVAENWVIKVCDMGLARKMDKSEKSKMTICGTDDWMAPEVLIGEEYDASCDVFSFGMVLIELITRENLTPRIRNEDLGVDQKFFLSKVPADCPKELLRLVSECCKVAPSGRPSASNILGLLEYILESELIVNSGGDYEPPLRSFKPPELHLPLNEKNNNNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLGNSGNIYDDFSFPRPYQPDDSAVDNINNNGNDDSHFSFPRPYQPGQSNINGGVNNNNSNDESHFSFPRPYQPGQSNINGCVNNNNNNSNNNNDSHFSFPRPHQTSVVILNDRGEEEPLVVSQKDQLEHDLEGGDDNEEDEMKQLKSQLNYSKFSFPRPYQSSKIISFNETELLSFPRPWNPESEENNNNKNNNNNEKSLLEDPKYSFPRPYNPDSDSNLSFKSTAKVITNPTPLTTTTTTTTATATTTSSSSTNSKVTTNSTSLPTTTTTTTTTTATTSSSSLSSIGKPPQSTYKVPTTINPSTSQRVITIPSRIVTSTATAQPKSRSNSNPPKPTVVISNSNNNFNDIVKPSSTIVNQNKTTTQPTTLINAPQKVTTPVNKQIQPLHKSNESVTVAATTATTPTTATSTTIKSSPTTPTSTNQNIEQIKITTPKDEDENKSETNDGGGDTVSHRRSRSLDIKNSTKAIIKKFEELTRFSSQQSNLVHQPSSSSSSTKQPPTSQFLQNPRMEAKLSFAQETLVFEKSPSTSPKSLDIPTSSSLTSNSNSSIPAPSSPTKKTFWNKPKK
What are the official names of this protein?
Probable serine/threonine-protein kinase DDB_G0275165.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Protein: XYLA_SINMW
Sequence: MSTGFFGDTAKIKYEGPESTNPLAFRHYNPDDVVLGKRMEDHLRFAVAYWHSFVWPGGDPFGGQTFERPWFKDSMEAAKLKADVAFEFFQLLGAPFYCFHDADVRPEGRNFAENTRNLNDIVDYFAKKQDESGVKLLWGTANLFSNRRFMAGAATNPDPDVFAFAAATVKTCIDATQRLGGENYVLWGGREGYETLLNTDLKRELDQLGRFLNLVVEYKHKIGFKGTILIEPKPQEPTKHQYDYDVATVYGFLKKYGLENEVKLNIEQGHAILAGHSFEHELALANALGVFGSIDMNRNDYQSGWDTDQFPNNVPEMALAYYHVLAGGGFKTGGTNFDAKLRRQSIDPEDLLIGHIGGMDCCARGLKAAAKMIEDKALSAPLEERYAGWNELEAQKMLQGGFSLEEIEARVLKADVNPQPKSGRQELLENVVNRYV
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U17L8_HUMAN
Sequence: MEDDSLYLGGEWQFNHFSKLTSPRPDAAFAEIQRTSLPEKSPLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYLNASLQCLTYTPPLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALEQLVKPEELNGENAYPCGLCLQRAPASNTLTLHTSAKVLILVLKRFCDVTGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHNGYYFSYVKAQEGQWYKMDDAEVTACSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRPATQGELKRDHPCLQVPELDEHLVERATEESTLDHWKFPQEQNKMKPEFNVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSMNSTDQESMNTGTLASLQGRTRRSKGKNKHSKRSLLVCQ
What are the official names of this protein?
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP17 subfamily.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum.
Protein: TBX20_CHICK
Sequence: MEYTPPPKPQLSSRANAFSIAALMSSGSSKDKEAAESTIKPLEQFVEKSSCAQPLSDLSGLEPHGDFSGSPSALCTEPLIPTTPIIPSEEMAKISCSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLMKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGEDDLGDDSQATQSRGSAFTTSDNLSLSSWVSSSTSFPGFQHPQSLSALGTSTASIATPIPHPIQGSLPPYSRLGMPLTPSAIASSMQGTGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV
What is the function of this protein?
Acts as a transcriptional regulator involved in heart developmental processes.
What are the official names of this protein?
T-box transcription factor TBX20, T-box protein 20, cTbx20.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS11_IDILO
Sequence: MAKTPTRSRKRVKKQVADGMAHVHASFNNTIITITDRQGNALAWATAGGSGFRGSRKSTPFAAQVAAERAGEMAKEYGLKNLEVFVNGPGPGRESSIRALNAVGYKITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RRF_METEP
Sequence: MATPEFDLGDIKRRMQGAVSSLSKDLGSLRTGRATPSLLDPIQVEAYGSSMPMAQVATVSVPEPRLLSISVWDRSMVTNVEKAIRESDLGLNPMTEGQTIRLRIPEMNEQRRKEMVKVAHKYTEEARVAVRHVRRDGLDILKKLEKDGAISQDDEKRQAAEVQKATDDAINEIDGVLASKEKEIMQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_AZOSB
Sequence: MAEITASMVKELREKTDAPMMECKKALTEAGGDMAKAEEVLRIKLGNKASKAAARVTAEGIVGTYLSADGKLAAMVELNCETDFVAKNDDFIGLAGSLATLVATKNPADVEALSALELDGQTVEAFRTALVGKIGENITVRRFSRIEAKGQVASYVHAGAKIGVLVDLVGGDEQLAKDLAMHIAASKPKSLDASGVSQELIESERRIAVEKAREAGKPEAMLEKIAEGTVQKFLKEVTLLGQPFVKDDKQTVEALLKARGASVASFVLYIVGEGIEKKVTDFAAEVAEQAAAAAAKK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_PAPBU
Sequence: MFINRWLFSTNHKDIGTLYMIFGAWAGMVGTGLSILIRAELGQPGSLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAITQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTIGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFTGYTLNDTWAKIHFTIMFVGVNMTFFPQHFLGLAGMPRRYSDYPDAYTTWNTISSMGSFISLTAVILMVFMIWEALASKRVVKSVPLTSTNLEWMHGCPPPFHTFEEPAFIKSSSK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HISX_MOOTA
Sequence: MLPLIDGKEVKRRWSGRLLAREGVAARVREIIAAVKREGQAAVERYTLELDGVDLKEAGFRVTREEIGAAYRAVSPDLLEALRIARDNIATYHRRQPRGSWMETAADGTILGQICRPLGRVGLYVPGGTAAYPSSVLMTAVPARVAGVREIALATPPRRDGTLPPLLLVAAAEAGVEEIYKMGGAQAVAALAYGTEKVAPVDKIAGPGNIYVTLAKKEVYGQVDIDMLAGPSEIVVIADGKARPDWVAADLLSQAEHDALAGAVLITPDAGLARAVGEEVTRQLEALPRREIASRSLADYGAAVVVTGLDAAMDLANSLAPEHLELYVSEPWSWLGRVENAGAIFLGPYSSEPLGDYLAGPSHVLPTGGTARFYSPLSVDTFLKKSSLIACNRAGFRAAAGYIQALARAEGLEGHARAIELREE
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: THII_SHIFL
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLTIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALVQYRDQLEGKTFCVRVKRRGKHDFSSIDVERYVGGGLNQHIESARVKLTNPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAVKSKIEAEEEKFDFSILDKVVEEANNVDIREIAQQTEQEVVEVETVNGFGPNDVILDIRSVDEQEDKPLKVEGIDVVSLPFYKLSTKFGDLDQNKTWLLWCERGVMSRLQALYLREQGFNNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAFA2_RHOER
Sequence: MGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATAECDSLIQLVNHDRAGERVLEELLIDAEARLAEEGIGGDIYLFKNNTDSAGNSYGCHENFLVARAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKAATFCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMAETTTMLKVGSAALVLEMIEAGVSFRDFALDNPIRAIREVSHDVTGKKPVRLAGGRQASALDIQREYHAKAVEHLRNREPDPQVEQVVDLWGRTLDAVEAQDFAKVDTEIDWVIKRKLFQRYQDRHGFDLSDPKIAQLDLAYHDIKRGRGVFDVLQRKGLVKRVTEDETIDDAVENPPQTTRAKLRGDFITAAQAAGRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDERVERLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase 2, Proteasome accessory factor A 2, Pup-conjugating enzyme 2.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: GUAAB_METAC
Sequence: MVKPEKFIPKAIEKISQEIKEGKAIIALSGGVDSSVCAELAYRAIGDRLQPIYIDTGLMRKGETERIKHIFSHMNLHVVYAKDRFLEALAGVTDPEEKRKAVGETFIRVFEDEAKRIAADYLIQGTIYPDRIESEGGIKSHHNVGGLPSVMDFEKIVEPIEDLYKDEVREVAWALQLPEEICERMPFPGPGLAVRILGEVTEEKLEVVREANFIVEEELLERFCPWQTFAAVLGKGTGVKGDIRAYGWIVAVRAVGSRDGMTAEALELPWEVLKHLEARITSEIPKVARVVYDITPKPPATIEFE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase.
Protein: DNLJ_HALHL
Sequence: MAEPTATREQAQQRMAQLRGEISEHDYHYYVLDRPTISDAEYDALFRELQRLEAAYPDLVSSDSPTQRVAGTAQEGFEAVVHDTPMLSLDNAFEADDLVDFDRRIRDRLGVASVVYTGEPKLDGISLSLTYQDGELVRAGTRGDGHTGEDVTANVRTLRSVPLRLRGDGYPGRLEVRGEVVIRKEDFERLNQARLDAGERPFANPRNAAAGSLRQLDPRITARRPLTLFTFGVGDPLALGVESHWQVLECLAGWGFRTTAPLEHLEGVSACQAYRDRLIEERDALPFEIDGAVFKVDDLAVREQLGFTARAPRWALAFKLPAREATTVVEAIVPSVGRTGKITPLARLQPVEVSGVTVARASLHNADELARMDVREGDTVMVRRAGDVIPQITDVVLAKRPEGAQPWRFEERVQACPECGSAVQRIEGEAAHRCVGGLYCPAQREGAILHFASRRALDIDGLGEKIVEQLVAKGLVVDLADLFRLGHAQLAGLERMGDKSADNLLAALDRARSTTLARFLYALGIPHVGEVTARRLAEAAYGLMVAVPRGDRAALRAAAGLDAQTAITSEALLRVMAAPADDLEAIEDVGPVVARAIAGFFAEPHNRQVVDHLCAAGVHWPEPDPPEQAESVSSLAGRAFVVTGTLETMTRDEAKAAIEACGGRVTGSVSRKTDYLVAGADAGSKLNKARELGVEVVNESGLRELLAGAGA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RF1_BURCJ
Sequence: MKTSMQRKLDQLSTRLAELNDLLSRENVTADLDQYRKLTREHAELGPVVEQYALWRQSRSDEAAAQELLADPSMRDFAEDEIRSAREGMARLETELQKMLLPKDPNDDRNIFLEIRAGTGGDESALFAGDLLRMYLRFAERQRWQVEMMSESASDLGGYKEVIVRIAGQGAYSRLKFESGGHRVQRVPATETQGRIHTSACTVAVMPEADEIGEVEINPADLRIDTFRASGAGGQHINKTDSAVRVTHIPTGIVVECQDDRSQHKNKDRALKVLAARIKDKQYHEQHAKEAATRKSLIGSGDRSERIRTYNFPQGRMTDHRINLTLYRLEAIMDGDLDELIGALVTEHQAELLASLGEAD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL6_HUMAN
Sequence: MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
What is the function of this protein?
Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability (PubMed:17075861, PubMed:12794819).  Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:12794819).  Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:20823453).  'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis (By similarity).  Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity).  Also acts as a myokine (Probable).  Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity).  Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018).  Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
What are the official names of this protein?
Interleukin-6, IL-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL35_ACTPJ
Sequence: MPKIKTVRGAAKRFKKTASGGFKRKQSHLRHILTKKTTKRKRHLRHKSMVAKADQVLVVACLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: KUP_STRA1
Sequence: MQHVNHSSFDKASKAGFIIALGIVYGDIGTSPLYTMQSLVENQGGISSVTESFILGSISLIIWTLTLITTIKYVLVALKADNHHEGGIFSLYTLVRKMTPWLIVPAVIGGATLLSDGALTPAVTVTSAVEGLKVVPSLQHIFQNQSNVIFATLFILLLLFAIQRFGTGVIGKLFGPIMFIWFAFLGISGFLNSFAHPEVFKAINPYYGLKLLFSPENHKGIFILGSIFLATTGAEALYSDLGHVGRGNIHVSWPFVKVAIILSYCGQGAWILANKNAGNELNPFFASIPSQFTMHVVILATLAAIIASQALISGSFTLVSEAMRLKIFPQFRSTYPGDNIGQTYIPVINWFLFAITTSIVLLFKTSAHMEAAYGLAITITMLMTTILLSFFLIQKGVKRGLVLLMMIFFGILEGIFFLASAVKFMHGGYVVVIIAVAIIFIMTIWYKGSKIVSRYVKLLDLKDYIGQLDKLRHDHRYPIYHTNVVYLTNRMEGDMIDKSIMYSILDKRPKKAQVYWFVNIKVTDEPYTAEYKVDMMGTDFIVKVELYLGFKMRQTVSRYLRTIVEELLESGRLPKQGKTYSVRPDSKVGDFRFIVLDERFSSSQNLKPGERFVMLMKSSIKHWTATPIRWFGLQFSEVTTEVVPLIFTANRGLPIKEKIELTTTGD
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS18_CAUVN
Sequence: MTDTTAPEAGAPAAAAGGARRPFFRRRKVCPFSGANAPKIDYKDVKLLQRYVSERGKIVPSRITAVSAKKQRELAKAIKRARFLALLPYVVK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.