PharMolix/UniProtQA huggingface dataset:
Protein: TDIF2_BOVIN
Sequence: MVVTRSARPQARNEATSVESLRQKNSAVTRLHVHPKGRKGSSPDNPNTTESQTTPERSPAPKTRKSGTTGSLPEMNKPATDGEISEAESDCSSVPEVQDPVFRVTRRRQILVAGTPVSSVRKRLKITRVSESHTEEVVSEADSHVSGISRIMPPTEITTRRSKAKSQREPKQESHVEVISDAESSCSDISFSGIATRRTTRSMQRKLQAQTEENNTKIVLENEKEIIHTPVNLEDSVNRRTSRLLARSLSQINKPNFSNNEIYNDPDDSFFGISGKKLAVKKTRNFTIREEKQDSISPLKEITKQNCKSLDEEAKKIIDGGKEGNEKNSQLNLSEFQDTGLQQLVSQRHSTPESDKTTSESSTLNHEAVMKSLAQTFAVVEMDRWNEERKNAIKTSDCSEPGDGSYSDSDEECTVIGVSEDMSKEKEVDSESDTKPSNLEFNTTQDKDDSVLLVLSSDESQQSEHSENEEDTVCFVENNGNKESLNGDSENLSHDNALFVIDTTPGLSADKNFYLDEEDKAGEVATEEEEEEEEEESEEELSDHDRNKDNEFSDEDNLLSNTKSKLLKLMSSSIDTGLNIKELGGLYINFNADKVQLNKRTLTQMKEKRKDELLQKTVITPEFEKNYCVPPYSESKYKLQKKRRQERQKTAGDGWFGMKAPELTDELKNDLKALKMRASMDPKRFYKKNDRDGFPKYFQIGTIVDNPADFYHSRVPKKQRKRTIVEELLADSEFRRYNRRKYSEIMAEKAANAAGKKFRKKKKFRN
What is the function of this protein?
Regulates the transcriptional activity of DNTT and ESR1.  May function as a chromatin remodeling protein.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
Deoxynucleotidyltransferase terminal-interacting protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: AMIE_HELPY
Sequence: MRHGDISSSPDTVGVAVVNYKMPRLHTKNEVLENCRNIAKVIGGVKQGLPGLDLIIFPEYSTHGIMYDRQEMFDTAASVPGEETAIFAEACKKNKVWGVFSLTGEKHEQAKKNPYNTLILVNDKGEIVQKYRKILPWCPIECWYPGDKTYVVDGPKGLKVSLIICDDGNYPEIWRDCAMRGAELIVRCQGYMYPAKEQQIAIVKAMAWANQCYVAVANATGFDGVYSYFGHSSIIGFDGHTLGECGEEENGLQYAQLSVQQIRDARKYDQSQNQLFKLLHRGYSGVFASGDGDKGVAECPFEFYKTWVNDPKKAQENVEKITRPSVGVAACPVGDLPTK
What is the function of this protein?
Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.  The highest level of acyl transfer activity is observed with acetamide.
What are the official names of this protein?
Aliphatic amidase, Acylamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: Y4246_XANC8
Sequence: MSPSTPTDPCPCGRAAGYAQCCGQYHAGAAAPDAETLMRARYSAYVRRNVDYLLASWHPSTRPAELALDEGGRTTWLGLNVQRAIATGADTAEVVFLARYRIGGGSAVRMTEHSRFVREDGHWYYLDAR
What are the official names of this protein?
UPF0225 protein XC_4246.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: O26M_CONTE
Sequence: MEKLTILLLVAAVLLSIQALNQEKHQRAKINLLSKRKPPAERWWRWGGCMAWFGLCSKDSECCSNSCDVTRCELMPFPPDW
What is the function of this protein?
Gamma-conotoxins may act on voltage-gated non-specific cation pacemaker channels (HCN).
What are the official names of this protein?
Gamma-conotoxin-like TxMEKL-0511, Conotoxin TxMEKL-0512.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MRS2_SCHPO
Sequence: MVLIVGFNLRTSIASFSPICRSLFLFPKYRSRIIRPVVLLEKPFDKHFYATDSNPLITGFPETSKNCPPSVAATKNRLLMNCTEFDDHGNVRVISGDFKKMDLCKQNGLLPRDLRKLNTSINSIVPVILVREGSILINLLHIRALIKANSVLLFDVYGSQHSHSQSQFIYELEGRLKQKSSDFGWLPYEMRALETILVSVVNTLDSELHVLHNLVSDLLADFELDINQERLRTLLIFSKRLSGFLKKATLIRDVLDELLEQDQDLAGMYLTERLKTGKPRDLDKHDEVELLLETYCKQVDEIVQQTDNLVGNIRSTEEICNIMLDANRNSLMLLGLKLSAMTLGLGFGAVVASLYGMNLQNGLENHPYAFYITTGSIFAFAAFLSSLGILKIRRLKRIQMALYHRCNLPISLDPRSLRPPYL
What is the function of this protein?
High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix.  Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.  It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.
What are the official names of this protein?
Mitochondrial inner membrane magnesium transporter mrs2, RNA-splicing protein mrs2.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CG065_HUMAN
Sequence: MRMAPTESTEGRRLWPGPREGGSGKETTSEKLSNLPRPHSYSPKRADAESFRGVPAAFKKCREVFRACWGSRELLFLFKAISEAGPAQNSCGITLEKAGGLEDTGSHWLSWARCKVLYINGFTDPWKDAQAWILIVSCKKGKGTPEREGRN
What are the official names of this protein?
Putative uncharacterized protein LINC02902, Long intergenic non-protein coding RNA 2902.
Protein: RT106_COCIM
Sequence: MGFVSVNNSQIINKAFGPNQPLQQRIYQALAASPDLRPLFEDIAKYTSDLQDATSNAAAPPQPSRSQAQPVLGEGPAPKKRKIANGGDSIRSSSALAGMTQDADLQIYVQDMSFAVPQRKKLQLEITRAPGNVEYLRARNQALNMIEFGVPFPKIQHVLCLPVPEKSQKQFNFCIIPEGNDGISAAKPGEPVYETIVWTVPDGPPRTAFLGSGTPAMEGASLAETYQGYLQSILDEKLKHTRVICPDEKEFVSAIPEPHRKGEKAFHVKAFRGSKEGYMFLLSTGIFFGFKKPLIFFAFDNIESISYTSVLQRTFNLNILTRSSTNPDHMQEFELSMIDQADYPGIDAYVKKHRLQDASLVEARRAKSLNINGEKGENQEAHAEGTESELLKAQRELEDQEDEEEEDYDPGSDGDSDGSGTSSEEEDDHYGDEDHGEGRNLVKEELGSEAEDVEV
What is the function of this protein?
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing.  Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA.  Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
What are the official names of this protein?
Histone chaperone RTT106.
What is the protein family that this protein belongs to?
Belongs to the RTT106 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TSAC_SHEPC
Sequence: MLQLHPSDIKDIVLNGGVIAYPTEAVYGLGCDPDNDTAIQKLLAVKQRPWQKGLILVASDFQQLLAYVDESQLTAEQLEFAFSKWPGPFTFVMPIKAQVSKYLCGEFDSIAVRVSAHAGVQALCRALNKPLVSTSANLAGEDPALTAAEILADFTGKIDALVLGELGEQRQPSTIIDARSGKILRNGQ
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA2_ACAM1
Sequence: MEAPKLDILKPVLQHIFAAFDQVEGEYPFELQSQEIGIVTSLGHGIARATGLLQVQSEELVKFPGDRMGLAFNLDPDEVGLILLDDGHSLKAGCEVQRTGRVLDVPVGEGLLGRVVDATGRPLDQRGLVTAQERRPVEREAPAIMDRAPVTVPLQTGIKAIDALIPIGRGQRELIVGDRQTGKTAIAVDTILNQKDQDVICVYCAIGQRSSAVAKLIAELRNRGAMDYCIVVVAEGEASPGLQYITPYAATTMAEYFMEQGQDVLIVYDDLIQHARAYRELSLLLRRPPGREAFPGDIFYIHARLLERATCLRPELGGGSLTALPIVETEAQNLSAYIPTNLVSITDGQIYLTPDLFQKGIFPAVDVGKSVSRVGGKAQLPAYRDVAGDLRLSYTQFEELESFARFGTRLEESTRQSLERGRRVREVLQQPQFQPLPVAEQIAVMLAVTQGQFDLVPIEQVSQAQQLIGEAIRRELPNICDRIQNAGQLSETDRETLLNWIANHILKDSDNEL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 2, ATP synthase F1 sector subunit alpha 2, F-ATPase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: QUEC_ACAM1
Sequence: MKAVVLLSGGLDSSTALYKAKADGADCYAISFDYRQRHRQELDSAVAIAQSAQVTQHQIVAFDLTLWGGSALTDTQIDLPSRSIEEMADHIPVTYVPARNSIFLSFALAYAETISAEQVYIGVNQLDYSGYPDCRPDFIQAMQEVFRLGTKLGREGQAIEICTPLINLHKSAIIELGNDLGVPWEQTWSCYSDGGGSPPLACGQCDSCQLRLAAFAQLGLSDPLSYAT
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: Y4780_KLEP3
Sequence: MFRWGIIFLVIALIAAALGFGGLAGTAAGAAKIVFVVGIILFLVSLFTGRRRP
What are the official names of this protein?
UPF0391 membrane protein KPK_4780.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL31B_LACLA
Sequence: MKQNIHPNYQPVVFMDTTTGFKFLTGSTKGSKETVEWEDGNTYPLIRVEISSDSHPFYTGRQKFQAADGRIARFEKKYGKQ
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: TPAN1_PANIM
Sequence: LWSG
What is the function of this protein?
Specific inhibitor of store-operated non-voltage-gated calcium channels.
What are the official names of this protein?
Tetrapandin-1.
What are the subcellular locations of this protein?
Secreted.
Protein: MEOX1_HUMAN
Sequence: MDPAASSCMRSLQPPAPVWGCLRNPHSEGNGASGLPHYPPTPFSFHQKPDFLATATAAYPDFSASCLAATPHSLPQEEHIFTEQHPAFPQSPNWHFPVSDARRRPNSGPAGGSKEMGTSSLGLVDTTGGPGDDYGVLGSTANETEKKSSRRRKESSDNQENRGKPEGSSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVWFQNRRMKWKRVKGGQPISPNGQDPEDGDSTASPSSE
What is the function of this protein?
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development.  Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994).  Binds specifically to the promoter of target genes and regulates their expression.  Activates expression of NKX3-2 in the sclerotome.  Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation.  While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner.  Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
What are the official names of this protein?
Homeobox protein MOX-1, Mesenchyme homeobox 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes predominantly in the nucleus.
Protein: DDA1_HUMAN
Sequence: MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEGESSAPPRKVARTDSPDMHEDT
What is the function of this protein?
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28437394, PubMed:28302793, PubMed:31686031, PubMed:31819272).  In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272).
What are the official names of this protein?
DET1- and DDB1-associated protein 1, Placenta cross-immune reaction antigen 1, PCIA-1.
What is the protein family that this protein belongs to?
Belongs to the DDA1 family.
Protein: SODM_MYCS2
Sequence: MAEYTLPDLDYDYGALEPHISGQINELHHSKHHATYVKGVNDAIAKLEEARANGDHAAIFLNEKNLAFHLGGHINHSIWWKNLSPNGGDKPTGELAAAIDDQFGSFDKFQAQFTAAANGLQGSGWAVLGYDSLGGRLLTFQLYDQQANVPLGIIPLLQVDMWEHAFYLQYKNVKADYVKAFWNVVNWDDVQNRFAAATSKTSGLIFG
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: MUTL_AQUAE
Sequence: MFVKLLPPEVRKVIAAGEVIESPVDVVKELVENSLDAKATKVEVEIVKGGKRLIRVKDNGTGIHPEDVEKVVLQGATSKIETEKDLMNISTYGFRGEALYSISSVSKFKLRSRFFQEKEGKEIEVEAGNILGTRRVGMPVGTEVEVRDLFFNLPVRRKFLKKEDTERRKVLELIKEYALTNPEVEFTLFSEGRETLKLKKSSLKERVEEVFQTKTEELYAEREGITLRAFVSRNQRQGKYYVFINKRPIQNKNLKEFLRKVFGYKTLVVLYAELPPFMVDFNVHPKKKEVNILKERKFLELVRELAGKEKPIVDIPLSQPVKTYKPTYEILGQMDETFILVKDSEYLYFVDQHLLEERINYEKLKDENLACRISVKAGQKLSEEKIRELIKTWRNLENPHVCPHGRPIYYKIPLREIYEKVGRNY
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: Y440_CLONN
Sequence: MRIIVDADACPGRNLIEKAAIENSVEVIMYCDINHELKSDYSEVRVVDSGFQSVDMKIINEAKENDIIVTQDYGVAAMVLGRKAFAISPKGYIYDDDNIDRLLFERHLSAKARRGGKKTFNPKKRTDEDNLRLYNNILKLINKAKEKSN
What are the official names of this protein?
UPF0178 protein NT01CX_0440.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: NUOI_METEP
Sequence: MKLDQVARSLLLKEFVSGFVLAMKYFFKPKATINYPFEMGHRGPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAGPRRNDGTRRTTRYDIDMVKCIYCGMCQEACPVDAIVEGPNFEFSVETREELLYDKQKLLENGDRWEREIARNIAVDAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: COX5A_MOUSE
Sequence: MLAAALRRCTAAAAARGLLHPASAPSPAAAVCSIRCYSHGSHETDEEFDARWVTYFNKPDIDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLNDFASAVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 5A, mitochondrial, Cytochrome c oxidase polypeptide Va.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5A family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: CLP1_SCHPO
Sequence: MKEIFIPKECEWRFEVDEPAIQIRLVSGNAEYFGTELALGPPYHFTRVKGAIYTWQGCTLEVEGEPSVEYVAEETPMSTYLNLHFALEGLRLQAENAAANDESSYGPCVCLIGPRSCGKTSVLKILESYALKQSRHPICVNLDPTQPMLALPGSISAFHNATILDIQDADGFGASTSTGPTHVLAKVPLVYNFGLDSPLDNPKLYKLSLSRLALAVHSRMSQSKDARVSGCLVDTSSIQENAEKYQDILHSIITDFRINIIIVLGSERLYSSMKRKYADATWLSVVKVSSSGGCIDREEEWIQQFQARCIKQYFYGDDRMPLSPLSMIVDSTQLVVYRVLEASESGPKSSVLPLGFEEENTQSEKQDGNTSLRLHGKGEFLERISTEAMTILQNSILAVSSVGEDEDEATVVDSCIIGYVFVSDVDDVKNRMTLLSPVPEQLPSNALIMGTCKWQE
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
mRNA cleavage and polyadenylation factor clp1.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ILVC_PHEZH
Sequence: MRVYYDRDADLSRILDKKIAIVGYGSQGRAHALNLVDSGVKNVAVALRPGSATAKKVEADGLKVMSVAEASAWADAIMILAPDELQAQIYRDEIAPNIKDGAALLFAHGLNVHFGLIEPKKTVDVLMVAPKGPGHTVRGEYQKGGGVPCLIAVHHDATGGAMDFGLAYASAIGGGRSGVIETNFREECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIYEGGIANMNYSISNTAEYGEYVTGPRIVTSETKAEMKRVLEDIQSGRFVRDFMQENAVGAPSFKATRRRNAEHPIEEVGGRLRAMMPWITKNKLVDTERN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: PDLI4_BOVIN
Sequence: MPHSVTLRGPSPWGFRLVGGRDFSVPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCRDHLTLSVSRPEGRSWPSTPEDNKAQAHRIHIDSEAQDGSPLTSRRPSATGLGPEDGRPGLGSPYGQSPRLPVPHNGSNSEATLLAQMGALHVSPPHSTDPARGLPRSRDCGVDLGSEVYRMLREPAEPAAAEPKQSGSFRYLQGMLEAGEGGERPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKARVKPPEGYDVVAVYPNAKVELV
What is the function of this protein?
Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation.  Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle.  Involved in reorganization of the actin cytoskeleton (By similarity).  In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers.  Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane.  Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton.  Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity).
What are the official names of this protein?
PDZ and LIM domain protein 4.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, dendritic spine. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Synapse, synaptosome. Note=Localizes to actin stress fibers in nonmuscle cells. Colocalizes with GRIA1 in early endosomes. Enriched in numerous but not all spine-like structures along dendritic branches. Colocalizes with actin and enriched at sites containing larger amounts of actin and alpha-actinin. Targeted efficiently to spines via its PDZ domain-mediated interaction with the alpha-actinin/actin cytoskeletal complex. Localizes to synaptosomes in brain (By similarity). Colocalizes with F-actin. Colocalizes with TRIP6 at cell-cell contacts and lamellipodia. In the cytoplasm, displays a fibrillar pattern with characteristic thick fibers and occasional clusters. Colocalizes with the actin stress fibers. Oxidative stress induces redistribution from cytoskeleton to cytosol. Colocalizes with SRC at the perinuclear region, but not at focal adhesions (By similarity).
Protein: RL1_SHIBS
Sequence: MAKLTKRMRVIREKVDATKQYDINEAIALLKELATAKFVESVDVAVNLGIDARKSDQNVRGATVLPHGTGRSVRVAVFTQGANAEAAKAAGAELVGMEDLADQIKKGEMNFDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFDADKLKENLEALLVALKKAKPTQAKGVYIKKVSISTTMGAGVAVDQAGLSASVN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: Y484_NITOC
Sequence: MFGWAVTFLIVALVAALLGFTGIAGIATEIAWILFVVGIILFVVFLVLGRRGRPPL
What are the official names of this protein?
UPF0391 membrane protein Noc_0484.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFTS_KLEP3
Sequence: MAEITASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAKKAGNVAADGVIKTKIEGNYGYILEVNCQTDFVAKDGGFQAFADKVLDAAVAGKISDVEVLKAQFEEERVALVAKIGENINIRRIAVLEGDVLGSYQHGARIGVLVAAKGADEELVKQLAMHVAASKPEFVKPEDVSAEVVEKEYQVQLDIAMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKSVGQLLKEHNADVTGFIRFEVGEGIEKVETDFAAEVAAMSKQS
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_RICTY
Sequence: MTELNKLTVADSVKGLKNKDFTSKELVNAHIKQIEKYKNLNAYVTETFDLALKQAEEADQNYAQNKARTLEGIPFAVKDLFCTKGIRTTACSNILKNFIPHYESSVTKNIFDKGGVMLGKTNMDEFAMGSTNITSCFGNVISPWKANDDNSDLVPGGSSGGSAAAVSGFMASAALGSDTGGSVRQPASFTGLVGFKPTYGRCSRYGMVSFASSLDQAGIFTRSVLDSSIMLEAMMGFDEKDSTSINAKVPELQSAIGSSMKNMKIGVPLSLGEGGIIEHDIMKMWHDTIELLKNAGAEIVDITLPHAKYGVAVYYVIAPAEAASNLSRYDGVRYGLRVEYENMTLDEMYEMTRSAGFGEEVKRRIMLGTYVLSSNCMDAYYFKAQKVRRLVANDFNNAFTKVNAILLPTAPSAAFKIGEKQNDPTIMYLNDLFTIPASLAGLPCVSVPAGLSARGLPLGMQIIGKQLDEYNVLKVASTIETGVKHIKFEPAGF
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.