PharMolix/UniProtQA huggingface dataset:
Protein: SCX2_TITPA
Sequence: KKEGYLVGNDGCKYSCFTRPAQYCVHECELRKGTDGYCYAWLACYCYNMPDHVRTWSRATNRCGS
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  This toxin is lethal to mice.
What are the official names of this protein?
Beta-mammal toxin Tpa2, TpNNX.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPB_LEPBL
Sequence: MSDSKYQIALIGGSGRMGRAIITVLSSSSKSTLSSSVVSGGSVFLGMDSGLHSGIKQNGVNFSSDLEAAVRSADCVIDFSTYQNLDFTLKACIQHRKPVVIGTTGLTELQKDALKVASKEIGIVYSPNMSIGVNLLFKLTEIAAKAMGENSDIEIQDIHHRHKKDAPSGTAEKLKSILLETLGRTSKNVIHGRHGILKERDPREIGIHTFRAGEVIGDHTVYFFTPEERIEITHRAQDRKTFAVGSIHAAEFLVGRKPGLYDMFAVLGL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMBD1_ASPNC
Sequence: MALLQTSLIWAVYAIVVAVLVMVASVFIYTYQTPRDRSSVVTFTCIVAITSLLATVLLLPVDVALTSSTTSSKLGQRKPWATQDEVDKIVSLLTAVYYLLYSLDAFLCLLAIPFVYFWYEEYDEVAVESGEQSAAKRLWTAFKYTISFIAIVVVLFIVGFLVPVANIKDSKVSDYLRKLLAENRGERVLTFTLGLLITMGLFLYILYTSTGLAVLPMRMIRAAPSVSDMTWKASTSAQLESNRERQRQLEGRCRGDPGLLSSKERRELDTLVRDERTLIRRQRLAEEADGEGQSRFMRAWLKTTAFFRPLKLLGGIAILLITLMIWISMLLTAIDKAKNSICKQRCGYILSGIGVFNPINWIFVQSAKVFPIDYAVLTVVVLLLFGSSVVGISTIGIRFLWIRIFHVRKGHTSPQALLLTTAMLMLTILALDYSIPMLVAPQYATFGPQTFCDRPQGQQSDCLTNKHLIKPCSELTDNTAAKRVCTPSVTSMFLNRVTISYPFFGTVFFWSQFIFLVIYLLVLVTSFIRHPKLDERLLDQEAEEAEEERLLTSSARGVGDTYQSVGGRNNFSTRAG
What is the function of this protein?
Probable lysosomal cobalamin transporter.  Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).
What are the official names of this protein?
Probable lysosomal cobalamin transporter.
What is the protein family that this protein belongs to?
Belongs to the LIMR family. LMBRD1 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: IF1C_NEPOL
Sequence: MNKQGLFQMEGLVIESLPNAMFRVRLQNGFVILAHISGKIRRNYIRIIVGDRVLCELTPYDLTKGRIVYRQRSTPRP
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LIPB_POLAQ
Sequence: MTVLVKHLGVVDYVSTYEVMRAFTKERNSTTPDEIWILEHPPVFTLGLAGDAGNLHSPSNQIPLVQVDRGGEITYHGPGQIVVYLLLDLKRLGIFVKELVSRIEQALINTLADFGLVAERRSGAPGIYVSLQPGISPEWIGAKVAALGLKVSKSCSYHGLALNVATDLEAFGRIHPCGYEGLKTVDMQTLGIKDNIDTISQRLLEHLQKQLMPT
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAY_HAEI8
Sequence: MNIAEFHQNIEQVWQKIEEELENQGADVDCETQGSVFTITFDNRTQIVINKQEPLLELWIASKLGGFHFAFKNGDWVSNDGQRFWDCFVEACAAHGENVQF
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: RSMG_NITMU
Sequence: MNPATQLADGIATLGLSITESNQARLLQYLALIQKWNRVHNLTAVREPEAMLALHVLDSLAVLPHIGGSRIADVGSGAGLPGIPVALARPEWRVVLVESNHKKAAFLQQARIELGLENVEVIGERMEGVRSNAGFNTVISRAFSDLADFVKLAGHLCARGEEQGTDCGRLVAMKGVYPHEELAQLPETFIVDNILSLTIPGLRAKRHLVVLKRAGQ
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_BUCA5
Sequence: MKIRPLHDRVLVKRQEVESKSAGGIVLTGSAAGKSTRGTVTAVGKGRVLDNGDIKPLDVKVGDVVIFNEGYGAKTEKIDNEELLILTESDILAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_CYTH3
Sequence: MEFTLEEIAHLLGGEVKGDGKAKVSSIAKIEEASSGSISFLSNPKYESFIYSTNASAVIVKKDFQPRESLKTSLILVDDPYTSFTTILEAYQQALNASKMGKEEPSFIGKNAVIGSNHYIGAFAYIGSNCKIGNNVKIYPQAYIGDNVTIGDNTTIYAGVKIYANCELGNQVTIHSGCVIGSDGFGFAPQADGTYKTIPQIGNVVIGNHVDIGANTVIDCATMGSTIIYDGVKIDNLIQIAHNVKIGKNTVIAAQAGISGSTTIGENCIIAGQVGIIGHIKIANKTTIAAQAGIGRTISEEGLTLLGSPAIEKLDFLKSFAIYRKLPTLQKRIEELEEKTLNLSGIKES
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: AMPP2_ASPFN
Sequence: MRVSEPSDVVIRSDDTCHIHLTWSGSERRSAAKQHARKVAMKLGVSSGLIYLVGQPTVNWGDSDQPQPFRQRRYFYYLSGIDEPDCYLTYDIQADLLTLYVPDFDLRRAVWMGPTLTIEEAHKQSDVDRVNFFAALQHDLEWWTTKNKGTRPIYVLHDSQQPLIPSKRLWLDNERLLPAMNAARVIKDEYELRMIRQANYISGLAHRKILEDIHRMSTEAEIESSFLATCVSHGAKNQSYAIIAGSGENAAVLHYVKNNEPLDGRQLVCLDAGAEWRCYASDVTRTIPLWTDWPSERARNIYRVVEEMQEECIRRIRKGVRFRDLQLLAHDIAIKGLQKLDILTNDCTSAIYESGASAVFFPHGLGHHVGLEVHDVSKRPITALDGNQANWGNHNFVPLLTDSSWSVPLLDEGMVVTIEPGIYFNRLALLNAQNQPLAKYINFDEAEKYIPIGGVRIEDDILVTAKGYENLTTAPKGEEMLEIIRRGIDNS
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase AFLA_084750, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: DAPAL_THEAC
Sequence: MYKGIVTPMITPMGQNGEIDYRATEILIDNLADFGVDGLFPMGSTGLFPMFSTDEKKKFLGFVRDHSKKIEVYAGVGSSSTQESVELSKYTEDIGIKVRVLMPTYYIKPDEDWMYRHFSTVISAASNDLFIYNIPQLSGSWISESLIEKLTREFSNVKGIKDSSGDMRFFSRIIRHKNEKFDIFQGQDDLLFLSLSIGASGGVCGLSNISPYITNLYHEFSAGNLEKARKIQIDEVNPLMYAINEATFPAGYYYAFYKMNGIKGGYRAPMVEPTTDQKKKIDQELTKIPKKQ
What are the official names of this protein?
Uncharacterized DapA-like lyase Ta1157.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR1_LACCA
Sequence: MPHEPKGLNEECGVFGVWGNPNAASITHLGLHTLQHRGQEGAGIVGLTKDGMRRHYGLGLLSEVFTNTDQLTPLIGRAALGHVRYSTAGGRVLENIQPLLFRFSDEAIALAHNGNLTNAISLRRQLEDQGAIFQSTSDTEVLMHLIRRQVGQPWLTQLKTALNEVHGGFAFVLLTEHGLYAAVDPHGFRPMVVG
What is the function of this protein?
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
What are the official names of this protein?
Amidophosphoribosyltransferase, ATase, Glutamine phosphoribosylpyrophosphate amidotransferase, GPATase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: Y2983_HALH5
Sequence: MSPELYNIFYESHRGSWAILIILFLVSYFLIKAGKGKAGKILHMIVRLFFVIMLITGAGMLVYWQFAFLFIVKGVLAIVLIYAMEMLLTRTSKGTIGQQARIYWIVFITCLVLVALIGYNVISF
What are the official names of this protein?
UPF0344 protein BH2983.
What is the protein family that this protein belongs to?
Belongs to the UPF0344 family.
Protein: PQQA_KLUIN
Sequence: MWKKPAFIDLRLGLEVTLYISNR
What is the function of this protein?
Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis.  PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide (By similarity).
What are the official names of this protein?
Coenzyme PQQ synthesis protein A, Pyrroloquinoline quinone biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the PqqA family.
Protein: ZIPA_PSEAB
Sequence: MDIGLREWLIVIGLIVIAGILFDGWRRMRGGKGKLKFKLDRSFANLPDDDGDSAELLGPARVVEHREPSFDEQDLPSVSARETKERKGGKRQEEPRQGDLDLDEGLALEADPSDAAEPVEPRKGKSKGRKEKEREKAPAVAAEPAPVDEVLIINVIARDESGFKGPALLQNILESGLRFGDMDIFHRHESMAGNGEILFSMANAVKPGTFDLDDIDNFSTRAVSFFLGLPGPRHPKQAFDVMVAAARKLAHELNGELKDEQRSVLTAQTIEHYRQRIIDHERRSLMQKR
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: TAF8_MOUSE
Sequence: MADTAAGPGGSGTRPGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQILREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEIQQMEETDSSEQEEQTDTENNALHISTDDSGAEKESASVLQQSSSLSGSRNGEESVIDNPYLRPVKKPKIRRKKSLS
What is the function of this protein?
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity).  TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity).  The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity).  The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (By similarity).  TAF8 is involved in forming the TFIID-B module, together with TAF5 (By similarity).  Mediates both basal and activator-dependent transcription (By similarity).  Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349).  Required for the integration of TAF10 in the TAF complex (By similarity).  May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (PubMed:11076765).
What are the official names of this protein?
Transcription initiation factor TFIID subunit 8, Protein taube nuss, TBP-associated factor 8.
What is the protein family that this protein belongs to?
Belongs to the TAF8 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell.
Protein: KATG_ENT38
Sequence: MSMSEETNNSLSSGKCPFHHGGSDQSAGEGTGSRDWWPKQLRVELLNQHSNRSNPLGEDFDYRKEFSKLDYSALKGDIKALLTDSQSWWPADWGSYVGLFIRMAWHGAGTYRSVDGRGGAGRGQQRFAPLNAWPDNVSLDKARRLLWPIKQKYGQKISWADLYILAGNVALENSGFRTFGFGAGREDVWEPDMDVNWGDEKAWLTHRDPESLAKRPLAATEMGLIYVNPEGPNASGEPLSAAAAIRATFGNMGMNDEETVALIAGGHTLGKTHGAAAATHVGVDPEGSLIESQGLGWTSTHGTGVGADAITSGLEVVWSQTPTQWSNYFFENLFKYEWVQTRSPAGAIQFEAVDAPEIIPDPFDPSKKRKPTMLVTDLTLRFDPEFEKISRRFLNDPQAFNEAFARAWYKLTHRDMGPKARYIGPEVPKEDLIWQDPLPQAVFNPSQEDIASLKAEIVASGLSVSELVSVAWASASTFRGGDKRGGANGARLALAPQRDWDVNAAAVRALPTLEAIQRTTNKASLADIIVLAGVVGVEQAAKAAGVYITVPFTPGRVDARQDQTDIEMFNLLEPIADGFRNYRAQVDVSTTESLLIDKAQQLTLTAPELTALVGGMRVLGANFDGSQNGVFTDRVGVLTTDFFVNLLDMGTQWKATDESNELFAGSDRASGEVKYTATRADLVFGSNAVLRALAEVYASQDASEKFVKDFVAAWTKVMNLDRFDVK
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: BOD1_HUMAN
Sequence: MADGGGGGGTGAVGGGGTSQASAGAATGATGASGGGGPINPASLPPGDPQLIALIVEQLKSRGLFDSFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPTMNKNQLRNGLRQSVVQSGMLEAGVDRIISQVVDPKLNHIFRPQIERAIHEFLAAQKKAAVPAPPPEPEGQDPPAPSQDTS
What is the function of this protein?
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
What are the official names of this protein?
Biorientation of chromosomes in cell division protein 1, Biorientation defective protein 1, Protein FAM44B.
What is the protein family that this protein belongs to?
Belongs to the BOD1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.
Protein: NU4C_PROMS
Sequence: MLGTLGAGLSNFPWLSASILFPIGSAFVIPFFPDKGDGKEVRWFALSIALITFLITVGSYINGFDISNENVQLKENISWLPDLGLTWSVGADGMSMPLILLTSFITALAVLAAWPVKFKPKLFFFLILVMDGGQIAVFAVQDMLLFFLTWELELIPVYLLLAIWGGKNRQYAATKFIIYTAGSSIFILLAALAMGFYGTEIPNFEFSHLAAQDFSQKFQILCYVGLLIAFGVKLPIVPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPVAHAQFAPLLIVLGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGATYDRTKTLKLDEMSGVGQKMRIMFALWTACSLASLALPGMSGFVSELMVFTGFVTDEVYTLPFRVVMASLAAIGVILTPIYLLSMLREIFFGKENPKLIEERKLIDAEPREVYIIACLLLPIIGIGLYPRLVTESYIASINNLVDRDLTAIKSAAKANIFSGTKKNDILKAPTI
What is the function of this protein?
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, NAD(P)H dehydrogenase I, chain 4, NDH-1, chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: IF2G_HALMA
Sequence: MTSNKQPEVNIGLVGHVDHGKTTLVQALSGEWTDQHSEEMKRGISIRLGYADATFRRCPEAEEPEAFTVDEHCDDHDVDTDHLRTVSFVDAPGHETLMATMLSGAAIMDGAVLVISATEPVPQAQTEEHLSALDIIGIDNIVIAQNKVDLVDEERAMQNYEQIQEFVEGTVAEGAPVVPISAGQEANIDLLIEAVQSEIPTPERDPDEDARMMVARSFDINRPGTTWDDLMGGVLGGSLVGGQLDADDEIELRPGREVEEGGKTEWQPVTTTVRSLQSGGDFVDTVTPGGLLGVGTGLDPAITKGDALAGQVAGPPGSLPPVHETFTMDVDLLERIVGDDGGEVDEISTGEPLMLTIGTATTVGSVTSARDDECEVALKRPVCAASGSKIAINRRVGARWRLIGVGTLR
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit gamma, aIF2-gamma, eIF-2-gamma.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: TLR3_HUMAN
Sequence: MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKNSVH
What is the function of this protein?
Key component of innate and adaptive immunity.  TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms.  TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection.  Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
What are the official names of this protein?
Toll-like receptor 3.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome.
Protein: MTNA_AERPE
Sequence: MRDIDPSLRREIESLERFLKVKPLYFDFDEGVFVWLDTRLIPFREVYRRTSDYRRVARAIVDMEIRGAPAIGVAAAYALALAAAEAASRGGEGFIEALSEARREIESTRPTAYNLFWATARVYGAVSEAFRRSGVDAAVRAGLEEATRIYVEDVRGNVEIGRVGARLLESGDTVLTHCNTGALATAGFGTALGVIRYAWMEGKDIRVITTETRPVLQGARLNVWELRKEGIPFKLVVDSAVGLIMSRGMVSKAIVGADRIVSTGHTANKIGTYMVAMAASRHGVPFYVAAPASTFQPDAGPEAIVIEERSPDEVRGVISEAGYVRITLGDVEAYNPSFDVTPPELITAFITDRGVIEPPFDVNIRRTLED
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Putative methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, MTNA-like protein, aMTNA, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: FTHS_VIBC1
Sequence: MQSDIEICRNTPLSSIATVAANAGLLPHELDTHGKHKAKVHPQCLERLTDNQDGKLVLVTAITPTPLGEGKTVTTIGLSQGLSKINQSVMACIRQPSMGPVFGVKGGAAGGGYSQVAPMDELNLHLTGDIHAVTAAHNLASAALDARLYHEQREGYDAFEARTSLRALKIDVERITWKRVMDHNDRALRMVKIGLNEEGKNINGFEREEGFDISAASELMAILALANDLKDLRQRIGRIVVAYDLNGNPVTTEDLQVAGAMAVTLKETIAPTLMQTLEGVPTLIHAGPFANIAHGNSSIIADQIALKLSSYVVTEAGFGSDMGFEKACNIKALAADRAPDCVVIVATLRGLKANSGHYDLRPGMAIPDSIFNPDQAALEAGFENLKWHINNVHKYGIPAVVAINQFPQDSGQELAELKALIERFNPEVKVAVSTVFAQGGEGAIELAQHVVETCEQGAQFRPLYTKKQSLKEKLMAVCEVGYGASNIEMSELAKQQLAHFEKLGFDDLAVCIAKTPLSITTDSAIKGAPSGFAVPIRELRLCAGAGFVYALSGNVMTMPGLPDKPTFMNLDLDDQGNIIGLS
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: PANB_SYNR3
Sequence: MSLTPRQLGEQLRQRKQRRQPIAVLTAWDALSASWAEAAGVDLVLVGDSLAMVALGHATTLPVTLEAMVQHTAAVERGLRHTPIVSDLPFLSYQCGPDQAVAAAGRFLKETGCAGVKLEGGEPETIAVIDRLVRSGIPVMGHLGLTPQSVHQLGYRRQATDPVAQERLWQRALELQQTGCFALVLEHVPAELATRLSAELSVPVIGIGAGEGCDGQVRVSADLLGLTPQQPPFSPALLDGRELFSQALRQWVQGVQSAPVPPANHSAPHC
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIS_SHESA
Sequence: MFDQTTNTEVHQLTVGKIETANGTIKPQLLRDAVKRAVTNFFAQLDGQEAQEVYEMVLSEVEAPLLDIIMQHTRGNQTRAANMLGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: CLPS_DEIRA
Sequence: MTRPTIPPGPPGAEGRTQTLERTETKKPRLWRVLLLNDDYTPMDYVVQVLEQFFRKTEQEAELIMLAVHHKGQGVAGVYTRDVAETKVAQVTAHAQREGHPLRVVAEPESEGE
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: RK20_ARATH
Sequence: MTRIKRGYIARRRRTKLRLFASSFRGAHSRLTRTMTQQRIRALVSAHRDRGKRKRDFRRLWITRINAVIHEMGVFYSYNEFIHNLYKKQLLLNRKILAQIALLNRSCLYTISNDIKK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.