PharMolix/UniProtQA huggingface dataset:
Protein: PYTI_ASPTE
Sequence: MDIVAHIQGDPGSSLTPLILIHAISGLALPYFALRPLSTDSDDGDSDKSRPVYGLSSPIFESVSAFRRHGKSLPSLALEYVRIIRREIQPRGPYLLGGWSMGGMLAIEMAAIFVAQGETVKHVVMIDSLNPEVYPPFQDSQEHQVLSTIMYNAIAWRVEGLEEACMPTLSDDASTTTSSDNSRASTDHGADSEVESEADLDDFMQQLREHVHQGMRMLASYHTLHRHIYLPDTAVTLIKCTMLGNLSPLLRASRKVFAKKNLLDPHNGWRTEQFRSFRSVPFASTHDACFDAEASEELTTILRGVLKDID
What is the function of this protein?
Thioesterase; part of the gene cluster that mediates the biosynthesis of pyranterreones, a family of antioxidative compounds (PubMed:32077283).  The first step of pyranonigrins biosynthesis is performed by the hybrid PKS-NRPS synthetase pytA that condenses 4 malonyl-CoA units ato the acetyl starter unit by the modular PKS of pytA (PubMed:32077283).  The acyl chain is then connected to an L-serine through the amide bond by the modular NRPS of pytA (PubMed:32077283).  A tetramic acid is formed and released from the PKS-NRPS pytA to give pyranterreone 5 with the help of the thioesterase pytI (PubMed:32077283).  Pyranterreone 5 could be methylated by pytC to afford pyranterreone 6 (Probable).  Both pyranterreones 5 and 6 are subsequently oxidized by the FAD-linked oxidoreductase pytB and the cytochrome P450 monooxygenase pytD to form the fused gamma-pyrone core, resulting in pyranterreones 7 and 11, respectively (PubMed:32077283).  The hydroxy group at C-8 of pyranterreones 7 and 11 are dehydrated by the aspartyl protease pytH to form a delta-7 double bond to give pyranterreones 3 and 1, 2 accordingly (PubMed:32077283).  The exo-methylene of pyranterreone 3 could be reduced into a pendant methyl by reductase pytE to provide pyranterreone 4, also known as cordylactam (Probable).  Pyranterreone 4 can be reconverted to pyranterreone 3 through pytB-catalyzed dehydrogenation or further oxidized to pyranterreones 9 and 10 (Probable).
What are the official names of this protein?
Thioesterase pytI, Pyranterreones biosynthesis cluster protein I.
What is the protein family that this protein belongs to?
Belongs to the AMT4 thioesterase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SHKE_DICDI
Sequence: MDINLIKQYINSSLPNDKESLIQYYGQLKQILNALSDKEQQQLLNNNGKISEQQQLSIENNYKVIGSIEEKMKSIEHLFNNLDVSDSNNNNSTSPVFISLDNQNTVNNNNNNNNNNNNNNNNNNNNNNNSLAPTVILDNNDNKKTAEIILPDHHNNTPQQQPEQQVQQQQVQQQQQVQQQQQQPEQQQQHLTEEQIQKQQQSQASIQQAIANMGEKKRSSSRHSGPPEIPPEEIKFDVKTDLLGGGAYGKVYKATCRGKKVAVKVPKKQTLSESELKSFKNEVEIMKQIFHPNVVLCLGACTKPGKVMIVSELMQTDLEKLIHSSEVEPPPLYERMKMCLDAALGINWLHGICNIIHRDLKLANLMISKDKTVKIGDFGFSQVIKTGTTLSDQKGPKGTALYMAPEVMMKHEFNEKADVYSFGLILYEMATCEELFPEYSEIDPFYDAICNKKLRPPIPDSFPKSLKTLIQKCWDHDPNKRPSFNEVTQRMNEVLTDTAISGLDAAMFWKYNFIKPESESVPWNEFVYKLSSVVNLPTQVLSPLAQLFVSQSYEEEIGGVVTMERFDLMNKWFGNFFNSKYGPAILYEMIELLKKRWFHFDISRDISEKRLRGRPENTFLLRLSANDPIKTPFTISKTKGSKPTHKRVSREDVQINEIKQFPMGYKFTVPLDGNELVFGSITQMVEELHRIGNLSIPCPITEIKVPYLTD
What is the function of this protein?
Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells.  Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway.  Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity).
What are the official names of this protein?
Dual specificity protein kinase shkE, SH2 domain-containing protein 5, SH2 domain-containing protein E.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily.
What are the subcellular locations of this protein?
Membrane.
Protein: CRL_SALA4
Sequence: MTLPSGHPKSRLIKKFTALGPYIREGQCEDNRFFFDCLAVCVNVKPAPEKREFWGWWMELEAQEKRFTYRYQFGLFDKEGNWTAVPINETEVVERLEYTLREFHEKLRDLLISMELALEPSDDFNDEPVKLSA
What is the function of this protein?
Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes.  Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32.
What are the official names of this protein?
Sigma factor-binding protein Crl.
What is the protein family that this protein belongs to?
Belongs to the Crl family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBL41_ARATH
Sequence: MDLVSSLPDDVRCHILSFLTTKESALTSVLSKKWRNLFTLVPNLDLDDSEYLHPEETKWEREEILDSFLDFVERVLSLQGNGPIRRFSLRCESGVPPARLNRWLCKVLQRGVADLELIIDFEDGYLLPRELFVSETLVNLRLKSEFGCIHWWPGAEGTFLPRLQSLDISSAMVFCDDKLQKLLPCFPVIEELRLVGMEWIDSHVTVSCATLTNQLLLSSTGSRTSKNPKSVSFDTPNLLSLAYSDLVAEDYPLVNMKSLFKARIILGVDDDQIARMRAPTNYLSEDDVVRRFGNVVKLMKGIQNVQQLHLHSDTLEVLSMCCESMPVFNNVKTLGIKSDYDRGWQAVPALLRNCPHLETLTFEGLVHHVTDKCGDACDCIFRKDKGRSLKSCPVKVVEIKEFRVTMKEMHLIEHFLDNFPCLKEMKIYREEYDPSPFGNDPQVDDLILDMIEEYKDIYSCNVQLLEPCDKWDEQ
What are the official names of this protein?
F-box/LRR-repeat protein At3g03030.
Protein: MENG_TROW8
Sequence: MGTNIHIDMVIHGKHTAEIRKMFNRVAQAYDRTNLVLSFLQDAHWRRAACKMLGVTAGEEVLDVGAGTGASTRTVARTGAAVTGIDISPRMLQIARNRCKRFQNITWRLTNGDLPFPDKSFDAILMVFCLRNVSNIQGFLCDAARVLKPGGRLVVCEFSHPRRFVAPFYRLYLRYVLPRLAKLISSDPAAYEYLTESIEDWYEVDELAFMLEQCGFQNTSWKRLSFGAVALHRALRGPE
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: ATPB_PYLLI
Sequence: MTKKKTEKEKGINNGYITQVIGPVIDAVFSSGILPKIYNALEVQSKEGPIICEVQQLLGDNRVRAIAMSATDGLQRGVTVIDTQAPIAVPVGKATLGRIFNVLGQPVDNLSDSVGEDTLPIHRSAPAFTDLETKPAIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINETNLLESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDINKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTEMGALQERITSTTQGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPLIVGDEHYKTAQLVKETLQRYKELQDIIAILGIDELSEEDRLVVDRARKIERFLSQPFFVAEVFTGSPGKYVDLENTIKGFNMILGGELDDLPEQAFYLVGDINEAISKAKTFKN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RS19_THEFY
Sequence: MPRSLKKGPFVDHHLMKKVLEQNEKGTKNVIKTWSRRSMVVPEMIGHTIAVHDGRKHVPVFITEAMIGHKLGEFAPTRTFRSHVKEDRRSRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: VDP_BOMMO
Sequence: MTNSLLICFTILGLAASSPTKPIGDIRIVGGEDIVITEAPYQVSVMFRGAHSCGGTLVAADIVVTAAHCVMSFAPEDYRIRVGSSFHQRDGMLYDVGDLAWHPDFNFASMDNDIAILWLPKPVMFGDTVEAIEMVETNSEIPDGDITIVTGWGHMEEGGGNPSVLQRVIVPKINEAACAEAYSPIYAITPRMLCAGTPEGGKDACQGDSGGPLVHKKKLAGIVSWGLGCARPEYPGVYTKVSALREWVDENITNLRLKHILRRF
What is the function of this protein?
Responsible for the degradation of vitellin in eggs at the head pigmentation stage.
What are the official names of this protein?
Vitellin-degrading protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: CHEB_SHISS
Sequence: MSKIRVLSVDDSALMRQIMTEIINSHSDMEMVATAPDPLVARDLIKKFNPDVLTLDVEMPRMDGLDFLEKLMRLRPMPVVMVSSLTGKGSEVTLRALELGAIDFVTKPQLGIREGMLAYSEMIAEKVRTAAKASLAAHKPLSAPTTLKAGPLLSSEKLIAIGASTGGTEAIRHVLQPLPLSSPALLITQHMPPGFTRSFADRLNKLCQIGVKEAEDGERVLPGHAYIAPGDRHMELARSGANYQIKIHDGPAVNRHRPSVDVLFHSVAKQAGRNAVGVILTGMGNDGAAGMLAMRQAGAWTLAQNEASCVVFGMPREAINMGGVCEVVDLSQVSQQMLAKISAGQAIRI
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_CHLPM
Sequence: MKQDIHPKYTEVTVNCANCGNTFVTRSTRDSIKVDICSNCHPFYTGKQTLVDTAGRVDRFNKRFAKSAASQAQAK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: TATA_MYCSK
Sequence: MGGLQPWHWVIVIAVFVLLFGAKKLPDAARSLGKSMRIFKSEIKEMQSEGKSDNPPATPITSERVDTNPTAEQPDKRSA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: OTC_BACC3
Sequence: MSTVQVPKLNTKDLLTLEELTQEEIISLIEFAIYLKKNKQEPLLQGKILGLIFDKHSTRTRVSFEAGMVQLGGHGMFLNGKEMQMGRGETVSDTAKVLSHYIDGIMIRTFSHADVEELAKESSIPVINGLTDDHHPCQALADLMTIYEETNTFKGIKLAYVGDGNNVCHSLLLASAKVGMHMTVATPIGYEPNEEIVKKALAIAKETGAEIEILHNPELAVNEVDFIYTDVWMSMGQEGEEEKYTVFQPYQINKELVTHAKQTYRFLHCLPAHREEEVTGEIIDGPQSIVFEQAGNRLHAQKALLVSLFKNVEELS
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHOSP_PHODV
Sequence: MAEEQAYHVSKGLECIKALRENPPNMEEIQEVSNIRDQTYKSSKESGTTGVQEEEITQNIDESHTPTKRSNSVSDVLQEDQRGREDNTAPVEAKDRIEEDTQTGPAVRRYYVYDHCGEKVKGIEDADSLMVPAGPPSNRGFEGREGSLDDSIEDSSEDYSEGNASSNWGYTFGLNPDRAADVSMLMEEELTALLGTGHNAGGQKRDGRTLQFPNSPEGSIGNQACEPIKKGTGEKLASHGMMTAAGLTNGATRSAPKSTGGSSGPNASAGSVPQSVTTAKMIQKCKTESGTRPQPEKPNEIESDGEYDDELFSEIQEIRSAITKLTEDNQSILSKLDTLLLLKGEIDSIKKQISKQNIAISTIEGHLSSIMIAIPGFGKDTGDPTANVDINPDVRPIIGRDSGRALAEVLKKPASSRGNQKDGGLILGSKGQLLKDLQLKPIDKNSSSAIGFKPKDSAPSKAVIASLIRSSKVDQSHKQNMLSLLKNIKGDDNLNEFYQMIKSISHI
What is the function of this protein?
Essential component of the RNA polymerase and the nascent chain assembly complex.  Also required during RNA synthesis.
What are the official names of this protein?
Phosphoprotein, Protein P.
What is the protein family that this protein belongs to?
Belongs to the morbillivirus P protein family.
Protein: PUMP1_ARATH
Sequence: MVAAGKSDLSLPKTFACSAFAACVGEVCTIPLDTAKVRLQLQKSALAGDVTLPKYRGLLGTVGTIAREEGLRSLWKGVVPGLHRQCLFGGLRIGMYEPVKNLYVGKDFVGDVPLSKKILAGLTTGALGIMVANPTDLVKVRLQAEGKLAAGAPRRYSGALNAYSTIVRQEGVRALWTGLGPNVARNAIINAAELASYDQVKETILKIPGFTDNVVTHILSGLGAGFFAVCIGSPVDVVKSRMMGDSGAYKGTIDCFVKTLKSDGPMAFYKGFIPNFGRLGSWNVIMFLTLEQAKKYVRELDASKRN
What is the function of this protein?
PUMPS are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation.  This leads to a decrease in the efficiency of oxidative phosphorylation and an increase in heat production.  Is involved in protecting plant cells against oxidative stress damage and maintaining the redox balance of the mitochondrial electron transport chain to facilitate photosynthetic metabolism.  May play a regulatory role during photorespiration.
What are the official names of this protein?
Mitochondrial uncoupling protein 1, AtPUMP1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VP10_SPHAA
Sequence: EDDLEDFNPTIA
What are the official names of this protein?
Venom peptide Sa10.
What is the protein family that this protein belongs to?
Belongs to the SA81-like family.
What are the subcellular locations of this protein?
Secreted.
Protein: YQGF_BARHE
Sequence: MAIININEVMIHLLPGQIIAGLDLGTKTIGIAVSDRGLIFSNPRSVLQRQKFTVDAQTLIKIFDHENVGVIIIGLPLNMNGSSGPRAQATRTFVRNMEAYTEIPFVFWDERLSTIAAERSLLEMDVSRAKRATRIDSAAAAFILQGALNRIHNLHHIEG
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJJB_YERPS
Sequence: MGVSLLWALLQDMVLAAIPALGFAMVFNVPVRALRYCALLGAIGHGSRMLMIHFGMNIELASLVASIMIGVIGINWSRWLLAHPKVFTVAAVIPMFPGISAYTAMISVVEISHLGYSEALMSTMVTNFLKASFIVGALSIGLSLPGLWLYRKRPGV
What is the function of this protein?
Involved in succinate export with YjjP.  Both proteins are required for export.
What are the official names of this protein?
Probable succinate transporter subunit YjjB.
What is the protein family that this protein belongs to?
Belongs to the ThrE exporter (TC 2.A.79) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRPE_SYNJA
Sequence: MPTEDAYPELQEEEIDVEAELEKLILEDREAEASTSSGEASAEASQDLSETLKQLQQELEITRQQLKEKEESYIRLYADFENYRRRTQREKEEFSQKERQKFVLEILPVVDSFERAQQQLKLETDREREVHNSYQSVYRLLVECLKKMGVSRMKSVGQPFDPNLHEAIARQPSSEYPEDVVAVEYQPGYKLGDLVIRHAMVAVSSGSPTSEPSPSDPATPKPEPESTPASPQNPQHS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUFS_SHIFL
Sequence: MTFSVDKVRADFPVLSREVNGLPLAYLDSAASAQKPSQVIDAEAEFYRHGYAAVHRGIHTLSAQATEKMENVRKRASLFINARSAEELVFVRGTTEGINLVANSWGNSNVRAGDNIIISQMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLETLPTLFDEKTRLLAITHVSNVLGTENPLAEMITLAHQHGAKVLVDGAQAVMHHPVDVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEMPPWEGGGSMIATVSLSEGTTWTKAPWRFEAGTPNTGGIIGLGAALEYVSALGLNSIAEYEQNLMHYALSQLESVPDLTLYGQQNRLGVIAFNLGKHHAYDVGSFLDNYGIAVRTGHHCAMPLMAYYNVPAMCRASLAMYNTHEEVERLVTGLQRIHRLLG
What is the function of this protein?
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation.  Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine.  Selenocysteine lyase activity is however unsure in vivo (By similarity).
What are the official names of this protein?
Cysteine desulfurase, Selenocysteine beta-lyase, SCL, Selenocysteine lyase, Selenocysteine reductase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: I18BP_MOUSE
Sequence: MTMRHCWTAGPSSWWVLLLYVHVILARATSAPQTTATVLTGSSKDPCSSWSPAVPTKQYPALDVIWPEKEVPLNGTLTLSCTACSRFPYFSILYWLGNGSFIEHLPGRLKEGHTSREHRNTSTWLHRALVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWDGLKTAPSPSQETLSSHSPVSRSAGPGVA
What is the function of this protein?
Binds to IL-18 and inhibits its activity.  Functions as an inhibitor of the early TH1 cytokine response (By similarity).
What are the official names of this protein?
Interleukin-18-binding protein, IL-18BP, Interferon gamma-inducing factor-binding protein.
What are the subcellular locations of this protein?
Secreted.
Protein: EX7L_LATSS
Sequence: MVKPTDYLTVTALTQYLKAKFERDPYLDRVYLTGEISNFRLRPNAHQYFSLKDNKAKISAIMFKSAFEKVKFTPEEGMKVLIVGRISLYEASGNYQIYVERMEPDGLGALYQAYEQLKAKLATEGLFDAPKQPLVRFPKRIAVITSPSGAVIRDIITTTQRRYPIAQLVLFPAVVQGDGAADVLVERLKQVNEHGDFDTIIIGRGGGSIEDLWPFNEERVARAIVASQIPVISSVGHETDTTIADLVADVRAATPTAAAELATPVLTDEILKLQQQRLRLYQAFSKTVALNKKQLDHLQNSYVLKQPKRLYDGYLQNVDQLQRRLLTAQQQLLKDRRQQVQLLQQRLMAQSPLMAVRQAQKDVTEQQRRLNQAMNRLMADRRQKAAQVIAALDLVSPLKILGRGFAYVTDDQQQMLKKVADFKTQQPIELHVQDGLVTAEVVATHKGEE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINY3_XENTR
Sequence: MSECDKELVDMVWGRNNSNGLADSVFKRWTQGFVFSASEPTALEQFEGGPCAVLAPVQAFLLKRQLFNTEHSNWRSCQDEEQKEILCHTLSDILEIVSFNSNSYCLASWLKEKATRETEQENPAESSQQNEQPTALAAEELGFERFHASIQKRKFNSLSELKEAVLETYSTWRNKYGVLLFLYSVILTKGIENVKNEIEDAERPLIDPVYGHGSQSLINLLLTGHAVSNVWDGDRECSGMKLQGIHSHADVGFLTILESLRFCKVGSFLKSPKFPIWVIGSETHLTVFFTKEMALVAPEAPSEQARRVFETYDPEDNGFIPDAVLEDVMKALDLVSDTDYVNLMKTKLDPEGLGIILLGPFLLEFFPEQSSKVPESFTVYHYNGLRQSNHNEKVAYIEGTAVMGFEDPRLQTDDTPVKCCLQTKWPFVELLWSADRPPSLI
What is the function of this protein?
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase MINDY-3, Deubiquitinating enzyme MINDY-3, Protein CARP.
What is the protein family that this protein belongs to?
Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: LRRC1_MOUSE
Sequence: MFHCIPLWRCNRHVEAIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESIAFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTYLVISQNLLETIPEGIGKLKKLSILKLDQNRLTQLPEAIGDCENLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTMFCIRDNRLTRLPAEVSQAVELHVLDVAGNRLHHLPLSLTTLKLKALWLSDNQSQPLLTFQTDIDRATGEKILTCVLLPQMPSEPICQESLPRCGALESLVTDMSEEAWNDRSVHRVSAIRFLEDEKDEDENETRTLQRRATPHPGELKNMKKTVENLRNDMNAAKGLDSNKNEVNHAAERVTTSV
What are the official names of this protein?
Leucine-rich repeat-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized at the basolateral side of epithelial cells.
Protein: ATG13_YEAS7
Sequence: MVAEEDIEKQVLQLIDSFFLKTTLLICSTESSRYQSSTENIFLFDDTWFEDHSELVSELPEIISKWSHYDGRKELPPLVVETYLDLRQLNSSHLVRLKDHEGHLWNVCKGTKKQEIVMERWLIELDNSSPTFKSYSEDETDVNELSKQLVLLFRYLLTLIQLLPTTELYQLLIKSYNGPQNEGSSNPITSTGPLVSIRTCVLDGSKPILSKGRIGLSKPIINTYSNALNESNLPAHLDQKKITPVWTKFGLLRVSVSYRRDWKFEINNTNDELFSARHASVSHNSQGPQNQPEQEGQSDQDIGKRQPQFQQQQQPQQQQQQQQQQQRQHQVQTQQQRQIPDRRSLSLSPCTRANSFEPQSWQKKVYPISRPVQPFKVGSIGSQSASRNPSNSSFFNQPPVHRPSMSSNYGPQMNIEGTSVGSTSKYSSSFGNIRRHSSVKTTENAEKVSKAVKSPLQPQESQEDLMDFVKLLEEKPDLTIKKTSGNNPPNINISDSLIRYQNLKPSNDLLSEDLSVSLSMDPNHTYHRGRSDSHSPLPSISPSMHYGSLNSRMSQGANASHLIARGGGNSSTSAFNSRRNSLDKSSNKQGMSGLPPIFGGESTSYHHDNKIQKYNQLGVEEDDDDEDDRLLNQMGNSATKFKSSISPRSIDSISSSFIKSRIPIRQPYHYSQPTTAPFQAQAKFHKPANKLIDNGNRSNSNNNNHNGNDAVGVMHNDEDDQDDDLVFFMSDMNLSKEG
What is the function of this protein?
Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy.  Required for autophosphorylation of ATG1 at 'Thr-226' and its dimerization.  May also be involved in the regulation of autophagy through SNF1.  Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure.  Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation.  Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy.  Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).
What are the official names of this protein?
Autophagy-related protein 13.
What is the protein family that this protein belongs to?
Belongs to the ATG13 family. Fungi subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: PRKX_MOUSE
Sequence: MEPPAGAAATVKDPDHDPVKTKVSAPAADPKPRTSSQKAGHSLQDWDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILACKIDFPRQLDFTSKDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWFRGVEWESVPQRKLKPPIVPKLSGDGDISNFETYPESELDKTPSVSDKDLETFKNF
What is the function of this protein?
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells.  Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis.  Regulates myeloid cell differentiation through SMAD6 phosphorylation.  Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis.  Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.
What are the official names of this protein?
cAMP-dependent protein kinase catalytic subunit PRKX, PrKX, Protein kinase X, Protein kinase X-linked, Serine/threonine-protein kinase PRKX, PKA-related protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
Protein: PROB_DEHM1
Sequence: MNGNCYKRIVIKLGTSLLTGGTGKLDHERMADLCRQIADLTRLGTEVIIVSSGAIAAGRAKMGLRHIPKDVPFKQVLAAIGQSQLMNYYDQLFSPHGLTVAQGLLTKSDLSDRSGYLNARNTLLALMELGVITIVNENDVVAVDEIQQAKFGDNDNLSAMVANLIEADLLLILTNIRGLYTADPTLHPDARLITEVKEITEELEKLAAGSSNKLGTGGMVTKLEAARLATSSGVNVIIADGHIPDIILKLASGETEGTRFMPSLHKPDSRQRWMMSGLCTRGNICIDDGAVKAIRENQKSLLAAGVQQSEGKFGRGDIVKLSDSRGKRLGYGITNYSSDDVSKIKGLHTDEINTVLAGNQGPEIIHRNNLVVI
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_POLNA
Sequence: MSMSDPIADMLTRIRNAQMVEKAVVLVPSSKVKVAIAQVLKDEGYIDGFSVKANDGKPQLEIALKYYAGRPVIERIERVSRPGLRVYKGHGAIPQVMNGLGVAIVTTPQGVMTDRKARATGTGGEVLCYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.