PharMolix/UniProtQA huggingface dataset:
Protein: SYE_SYNP2
Sequence: MTVRVRIAPSPTGNLHIGTARTAVFNWLFAHHHGGTFVLRVEDTDLERSKPEYTENIKTGLQWLGLHWDEGPFFQTQRLDQYKAAIQTLLDQGLAYRCYCTPAELEAMREQQKANNQAPRYDNRHRNLTEAQRAEFEAQGRKPVIRFKIDDAQQIVWQDLIRGTMTWKGSDLGGDMVIARTPEGDESFGQPLYNLAVVVDDIDMQISHVIRGEDHIANTAKQILLYEALGAAVPQFAHTPLILNQEGRKLSKRDGVTSIDDFRQMGFLPQAIANYMSLLGWTPTDSTQEIFTLEEAAKEFSLERVNKAGAKFDWDKLDWINAQYLHQMPIPALTDLLIPYLQAAGYGDYLGDRPWLESLVALVAPSLTRLADVTQETRLLFGDSITLDEKATAQLQTEGVKVILQEILQNIQASTNFTPDEAKALINQATKAHGVKKGVVMKSMRAGLMGELQGPDLMQSWVLLHQKGWDIERLNQAIASI
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHAM_ECOLI
Sequence: MFDSTLNPLWQRYILAVQEEVKPALGCTEPISLALAAAVAAAELEGPVERVEAWVSPNLMKNGLGVTVPGTGMVGLPIAAALGALGGNANAGLEVLKDATAQAIADAKALLAAGKVSVKIQEPCDEILFSRAKVWNGEKWACVTIVGGHTNIVHIETHDGVVFTQQACVAEGEQESPLTVLSRTTLAEILKFVNEVPFAAIRFILDSAKLNCALSQEGLSGKWGLHIGATLEKQCERGLLAKDLSSSIVIRTSAASDARMGGATLPAMSNSGSGNQGITATMPVVVVAEHFGADDERLARALMLSHLSAIYIHNQLPRLSALCAATTAAMGAAAGMAWLVDGRYETISMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHDVEQSIANLCALASHSMQQTDRQIIEIMASKAR
What is the function of this protein?
Plays a role in L-cysteine detoxification; it has been speculated to be a cysteine desulfhydrase (PubMed:27435271).
What are the official names of this protein?
UPF0597 protein YhaM.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: MATK_QUELY
Sequence: MEEFQGYLELDIFRQHDFLYPLIFREYSYALAHGHGLNRYMLLENIGYDNKSSLLIVKRLITTMYQQNYLIISANDSKQNPFFGYNKNLHSKILSEGFAIIVEIPFYLRLISSLEGAEIVRFYNLRSIHSIFPFLEEKFPHLNYSADILIPYPAHLEILVQTLRYRVKDASYLHLLRFFLHEYSNCNSLIITNKSISIFSKSNPRFFLFLYNSYICEYESIFLFLRNQSSHLRLTSSGVLFERLCLYRKIEHFAEVFANDFPVIPCFLKDPFMHYVRYQGKSILASKDTPLLMNKWKSYLVNLWQCHFDVWSHAASIRINQLSKHSLDFLSYFSSVRRNPAVVRNQMLENSFLLNNAPNKLDTIVPIIPLIGSLAKAKFCNAVGHPISKLTRADLSDFEIINRFLHICRNLSHYYSGSSKKKNMYRIKYILRLSCVKTLARKHKSTARAFLKRVDSEFFQEFFTEEGGFISLIFPRASFALRRLYSGRVWYLDIIFINGLSNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYS_LISMH
Sequence: MLDVKLLRNNFDEVKQKLQNRGEDLGEFEKFGELDKRRRTLIVETEALKSQRNEVSQEIAKLKREKQDADAKIEEMRVVGDRIKTLDIELREIDEKLDMILMSIPNIPHESTPVGESEDDNVEIRKWGEVREFDFEPKAHWDLGTDLDILDFENAAKVTGSRFVFYKKLGARLERALINFMMDLHSNEHGYEEMLPPYMVNRASMTGTGQLPKFEEDAFLIEAEDYFLIPTAEVPVTNYHREDILKAEDLPRKYTAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVQFVKPEDSYAALEKLTGNAEEVLRRLELPYRVLSMCTADLGFTAAKKYDLEVWIPSYNSYREISSCSNFESFQARRANIRFRREPGSKPEYVHTLNGSGLALGRTVAAILENYQDADGSVRIPKVLQGYMGGIEKIELPK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGUB_ORYSJ
Sequence: MAGGGGAGSKVSVAAVQFACTDVESENVDTAERLIREAHKKGANIVLVQELFEGQYFCQAQRLDFFQRAKPYKGNPTIIRFQKLAKELEVVIPVSFFEEANNAHYNSVAIIDADGTDLGLYRKSHIPDGPGYQEKFYFNPGDTGFKAFKTKYATIGVGICWDQWFPECARAMVLQGAEILFYPTAIGSEPQDNNLDSREHWKRVMQGHAGANLVPLVASNRIGRETVETEHGESTITFFGNSFIAGPTGEIVKLANDKDEDVLVAEFDLDEIKSTRHGWGIFRDRRPDLYKVLLTLDGEKS
What is the function of this protein?
Involved in polyamine biosynthesis.
What are the official names of this protein?
N-carbamoylputrescine amidase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily.
Protein: AROC_ECOLC
Sequence: MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLEIKDWSQVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRQRAQNADVKTDIPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: VATB_CLOBM
Sequence: MLKEYRTVKEVVGPLMLVDQVDGVSFDELVEIELHNGEKRRGKVLEINKDKAMVQLFEGSAGINLKGAKVKFLGKPLELGVSEDMLGRVFDGLGNPKDGGPKIIPDKKLDINGIPINPVARNYPDEFIQTGVSAIDGLNTLVRGQKLPVFSGSGLPHAELAAQIARQAKVLNSDSKFAVVFAAIGTTFEEAQYFIDDFTKTGAIDRAVLFINLANDPAIERIATPRMALTAAEYLAFEKGMHVLVIMTDITNYCEALREVSAARKEVPGRRGYPGYLYTDLSTLYERAGRILGKEGSITQIPILTMPEDDKTHPIPDLTGYITEGQIILSRELYKKGIMPPIDVLPSLSRLKDKGIGKGKTREDHADTMNQLFSAYAQGKQAKELSVILGESALSDTDKLYAKFADAFEEEYVSQGFTTNRTIEETLNLGWKLLTILPKSELKRIRDEYLEKYLSKAEESK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: PLSY_VIBVU
Sequence: MDAMAVTMTIIAYLLGSISSAVLICRVLRLPDPRGVGSNNPGATNVLRIGGKGAAAAVLLCDMLKGTIPVWSGYYLGIEPVLLGVIAIAACLGHMYPLFFHFQGGKGVATALGAIAPIGLDLTGMIMATWLLVAILFRYSSLAALVTVLLAPMYTWMIKPQYTLPVGMLCCLIVLRHHQNIRRLFTGEEPKIGEKKLQMPKSQ
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LYS2_LYCSI
Sequence: VWLSALKFIGKHLAKHQLSKLGR
What is the function of this protein?
Has strong antibacterial activity and biofilm inhibition effects against Gram-positive and -negative bacteria including E. coli, S. epidermidis, and A. baumannii and oxacillin-resistant S. aureus and meropenem-resistant P. aeruginosa (PubMed:27128941, PubMed:34506798).  Is not cytotoxic against human foreskin fibroblast Hs27 or hemolytic against mammalian red blood cells (PubMed:27128941, PubMed:34506798).  Its mechanism of action involves binding to lipoteichoic acid and lipopolysaccharide of Gram-positive and Gram-negative bacterial membranes, respectively, to destroy the bacterial membrane (PubMed:34506798).  In addition, it shows anti-inflammatory effects by inhibiting the expression of pro-inflammatory cytokines that are increased during bacterial infection in Hs27 cells (PubMed:34506798).
What are the official names of this protein?
Lycosin-II.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 05 subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: SYCC_CHICK
Sequence: MAAAPAEQGKGKRVQPPWSPPEGTKHSRLCLYNSLTRNKEIFQPQNGKKVTWYCCGPTVYDASHMGHARSYISFDILRRILRDYFKFDVFYCMNITDIDDKIIKRTRQNYLFEQYRKNKSTPAQLLEDVKTASELFSVKLSETTDPDKRQMLEKIQNAVKSAFDPLQEAVQAKLPAEEISRCHEILLEEAKDLLSDWLDSKFGSQVTDNSIFSELPKFWEGEFHKDMEALNVLPPDVLTRVSEYVPEIVAFVKKIVDNGYGYVSNGSVYFDTVKFGSSEKHSYAKLVPEAVGDQKALQEGEGDLSISADRLCEKHSPNDFALWKSSKPGEPSWDSPWGKGRPGWHIECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFENDNWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALQKHTARQLRLAFLMHSWKDTLDYSSNTMESAIQYEKFMNEFFLNVKDILRAPTDVTGQFQKWENQEAELNKNFYDKKAAIHEALCDNVDTRSVLEEMRSLVSQSNSYIAAKKSARQMPNRLLLENISCYLTQMLKIFGAIESDDAIGFPVGGNNQNINIESTVMPYLQVLSEFREGVRQIAREKKVTEVLQLSDALRDDILPELGVRFEDHEGLPTVVKLVDKDTLLKEREEKKKIEEEKKRKKEEAARKKQEQEAAKLAKMKIPPHEMFKSEHDKYSKFDENGFPTHDTEGKELSKGQIKKLKKLYETQEKLYKEYLQMVQNGSAN
What is the function of this protein?
Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
What are the official names of this protein?
Cysteine--tRNA ligase, cytoplasmic, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROL_ECO7I
Sequence: MTQPLFLIGPRGCGKTTVGMALADSLNRRFVDTDQWLQSQLNMTVAEIVEREEWTGFRARETAALEAVTAPSTVIATGGGIILTEFNRHFMQNNGIVVYLCAPVSVLVNRLQAAPEEDLRPTLTGKPLSEEVQEVLEERDALYREVAHIIIDATNEPSQVISEIRSALAQTINC
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_BUXMI
Sequence: MVREEVRVCTRTLQWKCVESRADNKRLYYGRFILSPLMKGQADTIGIAMRRALLGEIEGTCITCAKSEKIPHEYSNIVGIEESVHEILMNLKEIVLRSNLYGTRDASICVRGPRHVTAQDIISPPSVEIIDTTQHIASLTEPIDLCIGLQIERNRGYNMKTPKNSQDGRYPIDAVFMPVRNANHSIHSYGNGNEKQEILFLEIWTNGSLTPKEALHEASRNLIDLFIPFLHANEENFILKDNQNKVALPLFTFHDRLAKQRKNKKEISFQCIFIDQSELPPRTYNCLKRSNIHTLLDLLNNSQEDLMKIEHFRIEDVKQILGILQKHFAIDLPKNKF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SVF1_NEUCR
Sequence: MFKWAQAALANVAGTKEPIYGPEAIRSVAEEAKTTPYTETTKDDLKWQAMESTCVETQCFYFMTDSGQLAFAQVIYSNVAGIRTTCQFNCKVFSLDGSKPHLWCSTPLNNHEFSEDKTSFYATDCAVELSEDGNSYTIKSLNDERSIVNVTIKRTAPGFKIGTSGTTLFGTDLANPWGSMRHVFWPRCVAEGTIATPDGPVDCKGRAMFVHALQGMKPHHAAAKWNFCNFQGPNYSAVLMQYTTPPSYGSTVVNVGGIVKDNEIIFAGAEGAVTHVAIKGDTENDWPEPTAIKFEWKGTTKDGKQADAVLEGELEDKLDRIDVMAEVPGFVKQIVAGAVGTKPYIYQYAPQKKKLTLKLKLGEEEISEEGYLFSEATFISA
What is the function of this protein?
May be involved in the response to oxidative stress.
What are the official names of this protein?
Survival factor 1.
What is the protein family that this protein belongs to?
Belongs to the SVF1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DPO1_BORBU
Sequence: MKELYLIDALNIIFRNYHVMKNYPLLNTQGENVNAFIGFFKTLFFIIKEKNPEHLIITFDSEVPTFRKQKYPSYKATRDLPPDDLIPQIGWIKEGLLKAKIPIFEMEGYEADDLLASFAKKAAKNNYLTYIISPDKDLLQTMSEYVKILKIENNSFIEMDNEYVTKKFGVNSFQIKDYLAIVGDRSDNIPGIKGIGAKGAANLLREFKTLDGIYSNLEIINKKHRELLIKEKENAFLSYELVSLEENLKIPEIENFALKNFSEEIISLFEKHSAIALIKTYKKDILKQEKENADQKSLFKQEPTTNSLDDINTIDTENVKYRSITTKIELDDLIESLKKAKYISIDTETSSLDTYTAKLIGISISFKEFEGYYIPIEAKGKIYIEKNYIIQKFNNLFESNPKIIGQNYKFDYKILKNNGFNPIPPYFDTMIAAYLIDTNSKVSLDFLAEKYLMHKNIKYEDVIQKNDNFANISLEMATSYSSEDADITFRLFNIFTKKLKEDKLDKLMHEIEMPFNKVIIEMEENGIYLDKEYLKEYGKELGKELEAIENEIIKSIGIDFNLNSPKQMHEILFEKLNLKLPEKMKKDSTDIKVLESLREQHESIENLIKYRQIAKLKSTYTDNLIELINYKTNRLHTSFIQTKTATGRITSINPNLQNIPIKDEKGRKIRKAFKPENGNIFISADYSQIELAILAHLSQDEVLIKAFENNKDIHTETASKLFKIEEKEITPNLRRIAKSINFGIIYRMSDFRLAKELGITKEEAKGFINSYFDSYPKIKEFIINQINFVRNAGYSETILKRRRYIKEINSNNYLERSAAERIAINSIIQGSAADIMKIAMVKVFNEFKSKKMESKILLQVHDEMLIESPIEEENEVKKILKIMMETAYTLNLPLRANIETGKSWGEIH
What is the function of this protein?
In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
What are the official names of this protein?
DNA polymerase I, POL I.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-A family.
Protein: TDT_MONDO
Sequence: MHRIRTIDSDFGKKRQKKMDNHISSMIYEIKFHEFVLFILEKKMGATRRTFLTDLARKKGFRVENELSNSVTHIVAENNSGSDVLAWLKTHKMEKTTQFELLDISWLIECMKVGKPVDTKGKYQLMESRVDSANPDPTAGTLNILPPTTKTISQYACQRRTTINNHNQRFTDAFEILAKNYEFKENDDTCLTFMRAISVLKCLPFEVVSLKDTEGLPWIGDEVKGIMEEIIEDGESLEVQAVLNDERYQSFKLFTSVFGVGLKTADKWYRMGFRTLNKIRSDKTLKLTKMQKAGLCYYEDLIDCVSKAEADAVSLLVQDAVWTFLPDALVTITGGFRRGKEFGHDVDFLITSPGAEKEQEDQLLQKVTNLWKKQGLLLYCDLIESTFEDLKLPSRKIDALDHFQKCFLILKLYHHKEDKRKWEMPTGSNESEAKSWKAIRVDLVVCPYDRYAFALLGWSGSRQFERDLRRYATHEKKMMLDNHALYDKTKKIFLKAKSEEEIFAHLGLEYIQPSERNA
What is the function of this protein?
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.  One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
What are the official names of this protein?
DNA nucleotidylexotransferase, Terminal addition enzyme, Terminal deoxynucleotidyltransferase, TDT, Terminal transferase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-X family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MKAR_PODAN
Sequence: MASQIAQLLEKALHFWNAVPQPLQYTFAALGALYVLRGALSFVRLLLNSFILSGPNLRKYGKKGTWAVVTGASDGLGKEFASQLASKGFNLVLVSRTQSKLDALAKELRLKWSGLETKVLAMDFSQDNDEDYERLAKLIAGLDVGILINNVGQSHSIPVSFLDTEKTELQSIVTINCLGTLKTTKVVAPILAARKKGLILTMGSFAGTMPTPYLATYSGSKAFLQHWSSSLASELAPHGVDVQFVISYLVTTAMSKVRRTSLLIPGPKQFVKAALGKIGLDSNENFPNTYTPWWSHNVFKWIIDSTVGNTSAFTIWQNRKMHVDIRNRALRKAAREAKKQ
What is the function of this protein?
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate.  Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation.  VLCFAs serve as precursors for ceramide and sphingolipids.
What are the official names of this protein?
Very-long-chain 3-oxoacyl-CoA reductase, 3-ketoacyl-CoA reductase, 3-ketoreductase, KAR, Microsomal beta-keto-reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: YEEX_ECO27
Sequence: METTKPSFQDVLEFVRLFRRKNKLQREIQDVEKKIRDNQKRVLLLDNLSDYIKPGMSVEAIQGIIASMKGDYEDRVDDYIIKNAELSKERRDISKKLKAMGEMKNGEAK
What are the official names of this protein?
UPF0265 protein YeeX.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: DXS_NITSB
Sequence: MNIKNYTIEELEELSQKIRQRILEVVSKNGGHLSSTLGAVELIVSMHYVFDVEKDPFIFDVSHQAYAHKLLTDRWEQFDTLRQFGGISGYTKPKESPYDYWVAGHSSTSISLAVGAAKAIALKNEDRVPVVLIGDGAMSAGMVYEALNELGDRKYPVVIILNDNEMSIAKPIGAVSKYLSQKMASPFYQNMKKRTEQLLKHLPESATYIAKRMEESLKLITPGILFEELGIDYIGPIDGHDLKVLIETLTIAKQMNRPVIIHAQTLKGKGYKIAEGYYEHWHGVGPFDISTGESLKKSTKPSATSIFSKKLYDLAKEDETVVGVTAAMPSGTGLKPLIEDFGDRFWDVGIAEQHAVTSMGPLAKEGFKPFVAIYSTFLQRGYDQVIHDIALMDVGVAFAIDRAGIVGEDGETHQGAFDVSYLRPIPNMHLFAPRDPKTLEYAVEFAKDFDRPCAFRYPRGSFILDDEFEAKPFELGKAELLVESEGDVLFVGYGNGVGRAYETMKHIDEPVSLLDLRFVKPLDVELLQELSKRYRQWFVFSDSAKLGGVASALLELELPVEIVTFEYEDQFIPHGKVIDVEKALGLLPQQLAKRVKSFI
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: HSCB_VIBVY
Sequence: MNHFELFGLPPQFSLDGSLLSSQFRELQKRFHPDNFATASERDRLLAVQKAAQINDAYQVLKNPISRAEYLLSQNGLEIRGEQQTMQDPMFLMEQMELREELEEIPHGSDAESALAAFDARVSKMYKQHLASIEQELNDAQWPQAADRVRKLKFIAKLKNEIELVEEKLFG
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: PROA_METS4
Sequence: MSVLSLKPRAGADDVDALMREIGRRARAASRRMALVPARAKDMALRAAAAAIRDAAPVILEANAADLAEARGANLPAATLDRLALTPGRVEAIAAAVEAIAGLPDPVGRQLAAFERPNGLAIERISTPLGVVGVIYESRPNVTADAGALCLKAGNAAVLRAGSESLRSAAAIARAMADGLAAQGLPAEAIQLVPTRDRAAVGAMLAGLDGCIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHVFVHARADLAMAREILRNSKLRRTGICGAAETLLVDRACAGTHLAPLVADLLEAGCAVRGDAETQAVDPRVTPATEADWRTEYLDAVIAVRVVDGLDAAIDHVETYGSHHTDAIVTADEAAAERFLAEVDSAIVVHNASTQFADGGEFGFGAEIGIATGRMHARGPVGVEQLTTFKYRVHGSGQVRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_CUPMC
Sequence: MTVSQIPIAAIATAPGRGGIGVVRVSGPDVGAVMRAVCGRALQPRHATYLPFLDARGNVIDHGLALYFPAPNSYTGEEVLELQGHGGPVVMQMLLSRCLEAGKDIGLRVAEPGEFTRRAFLNDKLDLAQAEAVADLIEASTEAAARSAARSMEGEFSKAIHALVEKVIHLRMLVEATLDFPEEEIDFLEASNARGQLTRIREDLAGVLKQARQGSLLREGLSVVLAGQPNVGKSSLLNALAGSDLAIVTPIAGTTRDRVRETIQIDGIPLHIIDTAGLRDDAADEVERIGIERTWEAIRHADIVLHLIDAADYIEHGISETDDHIDDRLSGQLPPGSPIVRVINKIDLAPSVGAMGFGGNRPHVVAANGPNPTEIWISARTGAGIDLMRSELLRLIGWQSGNEGAFLARERHLIALRNAESHLELAEASASQHAQALDLFAEELRLAQDHLNSITGEFTSDDLLGTIFTRFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GL_HCMV2
Sequence: MCRRPDCGFSFSPGPVILLWCCLLLSIVSSAAVSVAPTAAEKVPAECPELTRRCLLGEVFQGDKYESWLRPLVNVTGRDGPLSQLIRYRPVTPEAANSVLLDDAFLDTLALLYNNPDQLRALLTLLSSDTAPRWMTVMRGYSECGDGSPAVYTCVDDLCRGYDLTRLSYGRSIFTEHVLGFELVPPSLFNVVVAIRNEATRTNRAVRLPVSTAAAPEGITLFYGLYNAVKEFCLRHQLDPPLLRHLDKYYAGLPPELKQTRVNLPAHSRYGPQAVDAR
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Acts as a functional inhibitor of gH and maintains gH in an inhibited form.  Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH (By similarity).  In human cytomegalovirus, forms two distincts complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope.  The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA.  The gH-gL-UL128-UL130-UL131A pentamer is essential for viral entry in epithelial, endothelial and myeloid cells via interaction with host NRP2 (By similarity).
What are the official names of this protein?
Envelope glycoprotein L, gL.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein L family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans- Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans- Golgi where secondary envelopment occurs.
Protein: HUTI_BURL3
Sequence: MKPTVWHHLRLCPHGHPDETIDDAAIAVDETGTIVWLGAMSALPHGYAHWQREDLHGAWVTPGLVDCHTHLVYGGTRADEFAQRLAGVSYEEIARQGGGIVSTVRATRAADETTLFVQAAARLQPLLAEGVTAIEIKSGYGLDLASERKMLRVARQLGERFPVTVYTTFLGAHALPPEYAGRADAYIDEVCDRMLPALADEGLVDAVDVFCERIGFSLAQTERVFEAATRRGLPVKLHAEQLSNAGGTALAARYRALSADHLEFLDEAGIEAMKAAGTVAVLLPGAYYFIRETQLPPIELLRKHGVPIALATDHNPGTSPLESLLLTLNMGCTLFRMTVPEVLQGVTRHAAAALGRADRHGALEVGRQADFAAWSVGSLAELAYWIGRPLCEQVVRGGTTVFRRMNG
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_KLEP3
Sequence: MSEMEQQPIFKIALGIEYDGSKYYGWQRQNEVRSVQEKLEKALSQVANEPITVFCAGRTDAGVHGTGQVVHFETRAQRKDAAWTLGVNANLPGDIAVRWVKHVPADFHARFSATARRYRYVIYNHRLRPAVLSHGVTHFHQPLDAERMQRAAQCLLGENDFTSFRAVQCQSRTPWRNVMHINVTRYGAYVVVDIKANAFVHHMVRNIVGSLMEVGAGNQPESWMAELLAAKDRTLAAATAKAEGLYLVSVDYPAHYDLPVLPMGPLFLAD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: G6PI_DEIDV
Sequence: MSAALTETPAWQALQAHFETLHSVHLRDLFAADPGRGERLTAEGAGLYLDYSKHRVTDETLDLLVALAHARGLPERRDAMFGGEKINVTEGRAVLHTALRAPRGSDVLVDGRNVVPDVHEVLERMAAFAQQVRSGSWLGHTGKPIRAIVNIGIGGSDLGPVMAYEALRHYAQRELTVRFVSNVDGTDLVEKTRDLTAEETLFIVSSKTFTTQETMANAQSARAWLLSALGDEAAVARHFVAVSTNAEAVQKFGIDTANMFEFWDWVGGRYSMDSAIGLSLMLAIGPDGFRELLSGFHDMDEHFRTAPLEANLPVLMGLLGVWYNNFFGAETLAVLPYDQYLAYFPAYLQQLDMESNGKHVTLDGQEVTYQTGPVVWGQPGTNGQHAFYQLIHQGTKLIPCDFIAFAQTLNPLPLPGGAPHHDLLMANVFAQTEALAFGKTLEEVLAEGVDAALAPHRVFDGNRPTSTLLVDRLTPRTLGALIALYEHKVFVQGVIWDVNSFDQWGVELGKVLARRIVKELGADEPELSHDSSTNALIRRYRERR
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.