PharMolix/UniProtQA huggingface dataset:
Protein: NU4LM_SCYCA
Sequence: MSPMYFSFSSAFMLGLMGLAFNRSHLLSALLCLEGMMLTLFVATATWSLMLNSTSSSILPMILLTFSACEASAGLAILVATSRSHGSDNLQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: DAD1_ASHGO
Sequence: MIMSKDIATTPELSEPDKYFVEQRDLLLQEITSTLDSILNNLNGLNISLENSIAVGKEFESVSELWKVFYDGLANGAAPGVAAANPSSQDLPTEPVAAHQNAAAGNSDAPAPSQ
What is the function of this protein?
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
What are the official names of this protein?
DASH complex subunit DAD1, Outer kinetochore protein DAD1.
What is the protein family that this protein belongs to?
Belongs to the DASH complex DAD1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Protein: MSP1_GLORO
Sequence: MAQLPPEDIATMPAQKVVFNAPFDNKATYYVRIINPGTKRIGFAFKTTKPKRINMNPPNGVLGPKESVNVAISCDAFDPSSEDTKGDRVTVEWCNTPDPAAAAFKLEWFQGDGMVRRKNLPIEYNV
What is the function of this protein?
Central component in molecular interactions underlying sperm crawling.  Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod (By similarity).
What are the official names of this protein?
Major sperm protein 1.
What are the subcellular locations of this protein?
Cell projection, pseudopodium. Cytoplasm, cytoskeleton.
Protein: CTU1_ORYSJ
Sequence: MDSAVDGPRQPPARAGSRLCTRCGERKAALKRPKTLEQICRECFYVVFEDEIHQTIVDNNLFKPGDRVAIGASGGKDSTVLAYVLSELNRRHKYCLDLFLLSVDEGITGYRDDSLETVKRNEIQYGLPLKIVSYKDLYGWTMDDIVKAIGLKNNCTFCGVFRRQALDRGAALLKVDKIVTGHNADDIAETVLLNILRGDIARLSRCTFITTGEDGPIPRCKPFKYTYEKEIVMYAYFKKLDYFSTECIYSPNAYRGFAREFIKDLERMRPRAILDIIKSGENFRISTTTRMPEQGTCERCGYISSQKLCKACVLLDGLNRGLPKLGIGRTKGIAGGDGDCEQQATRSERNRSSLQGKHGNFDF
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, Cytoplasmic tRNA adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYG_PSEGE
Sequence: MADFDMVLKCWGLVEADYATYGSLVLTRLFTEHPETLKLFPKFAGIAHGDLAGDAGVSAHGATVLNKLGDLLKARGGHAALLKPLSSSHATKHKIPIINFKLIAEVIGKVMEEKAGLDAAGQTALRNVMAVIIADMEADYKELGFTE
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: FKB65_ARATH
Sequence: MEDDFDTQNQFPEEEPEEMDMDLPDNDEADSAPYLKIGEEMEIGKSGLKKKLVKECEKWDTPENGDEVEVHYTGTLLDGTKFDSSRDRGTPFKFTLGQGHVIKGWDLGIKTMKKGENAIFTIPPELAYGETGSPPTIPPNATLQFDVELIAWRSVKDICGDGGVSKKIIVEGEKWEKPKDLDEVYVKYEARLEDGTIVGKSDGVEFTVKEGHFCPALSKAVKTMKRGEKVLLTVKPQYGFGEFGRPASDGLQAAIPPNATLQIDLELVSWKTVVEVTDDRKVIKKILKEGEGYERPNEGAIVKLKLIGKLQDGTTVFVKKGHEEDEEPFEFKIDEEQVIEGLEKAVMGMKKGEVALITISPEYAFGSSESKQELAVIPPNSTVYYEVELVSFIKEKESWDMNTQERIEAAGKKKEEGNVLFKAGKYARASKRYERGVKYIEYDSTFDEEEKKKSKDLKIACNLNDAACKLKLKDYKEAAKLSTKVLEMDSRNVKAMYRRAHAYLETADLDLAELDIKKALEIDPDNKEVKIEYKKLKEKVKEYNKKDAKFYSNMLSKMLEPHKGTQKEAQAMSIDTKA
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  Co-chaperone that negatively modulates thermotolerance by interacting with FKBP62 and decreasing the HSFA2-mediated accumulation of chaperones of the small-HSPs family.  Plays a positive role in tolerance to intracellular acid stress by maintaining the pH homeostasis.  May be a part of transcription regulation pathways upon pathogen infection.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP65, PPIase FKBP65, 70 kDa peptidyl-prolyl isomerase, FK506-binding protein 65, AtFKBP65, Immunophilin FKBP65, Peptidyl-prolyl isomerase ROF2, Protein ROTAMASE FKBP 2, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Relocalization from the cytoplasm into the nucleus is induced by heat shock.
Protein: GRF8_ARATH
Sequence: MRMLLGIPYVDKSVLSNSVLERGKQDKSKLLLVDKCHYELDVEERKEDFVGGFGFGVVENSHKDVMVLPHHHYYPSYSSPSSSSLCYCSAGVSDPMFSVSSNQAYTSSHSGMFTPAGSGSAAVTVADPFFSLSSSGEMRRSMNEDAGAAFSEAQWHELERQRNIYKYMMASVPVPPELLTPFPKNHQSNTNPDVDTYRSGMFSIYADYKNLPLSMWMTVTVAVATGGSLQLGIASSASNNTADLEPWRCKRTDGKKWRCSRNVIPDQKYCERHTHKSRPRSRKHVESSHQSSHHNDIRTAKNDTSQLVRTYPQFYGQPISQIPVLSTLPSASSPYDHHRGLRWFTKEDDAIGTLNPETQEAVQLKVGSSRELKRGFDYDLNFRQKEPIVDQSFGALQGLLSLNQTPQHNQETRQFVVEGKQDEAMGSSLTLSMAGGGMEETEGTNQHQWVSHEGPSWLYSTTPGGPLAEALCLGVSNNPSSSTTTSSCSRSSS
What is the function of this protein?
Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues.  Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation.
What are the official names of this protein?
Growth-regulating factor 8, AtGRF8, Transcription activator GRF8.
What is the protein family that this protein belongs to?
Belongs to the GRF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYS_BURCE
Sequence: MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNTLSKQIGAMKAKGEDTSAVMAEVGGIGDEMKASAAKLDEIQARLSELLLGMPNLAHESVPVGKDEADNVEVRRWGTPRQFDFDVKDHVDIGTPLGLDFETGAKLAGARFTMLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISLTNTVRESIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPESSYAALDEMVGHAEAILQKLGLPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPEVLRPYMGGLERIDAPAQAS
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSCA_AERHH
Sequence: MALLQIAEPGQSAAPHQHKRAVGIDLGTTNSLVAAVRSGQADTLCDEQGRDLLPSVVHYQADTIRVGVDAKREAALDPHNTIVSAKRMMGKALADIDTRQQPYQFVAADNGMPQLQTRQGLVNPVQVSAEILKKLAERGAAALGGDLDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLHRGVFEVMATGGDSALGGDDFDHLLADWLKEQAGLTGELDARLQRELLDVAAAVKHGLTDADAVPCTFAGWQGSVTRSQFDELIQPLVKRTLLACRRALRDAGLEQEEVLEVVMVGGSTRVPLVRELVGEFFQRPPLTSIDPDKVVAIGAAIQADILVGNKPDAEMLLLDVIPLSLGLETMGGLAEKVIPRNTTIPVARAQEFTTFKDGQTAMAIHVVQGERELVADCRSLARFTLTGIPPMVAGAAHIRVTFQVDADGLLSVSAMEKSSGVQAEIQVKPSYGLGEDDILNMLSASIANAQQDMDARMLAEQQVEADRVVESLNAALAADGEALLSPAERAELDAAIAHLLTMRSTGTTNQIKEAIEAADAASGEFAARRMDASIRKVLTGQNVNKV
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PDXS_THEMA
Sequence: MEIKKGTWIIKKGFAEMFKGGVIMDVTSAEQAKIAEEAGAVAVMALERVPADIRKEGGVARMASIAKIREIMEAVSIPVMAKVRIGHIAEAKILEELGVDFIDESEVLTPADDRFHINKHEFKVPFVCGARDLGEALRRIAEGAAMIRTKGEAGTGNVVEAVKHMRRVMEQIKQVTKMEDEELVAYGKEIGAPVELLREVKRLGRLPVVNFAAGGVATPADAALMMMLGADGVFVGSGIFKSKDPRKMAKAMVLAVTYWDNPRILLKISEDIGEPMRGLDVEELEVRMQERGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: ZBED5_CANLF
Sequence: MIAHLLCILSYNFNTSVILNVYSKLTMFCTTNTLPMDLLLKQGSLKQEVESFCYQIVSESNDQKVGILQSENEQLQPSVSKKSEGELSRVKFMSSSNKITTFSKKPKRRKYDESYLSFGFTYFGNRDAPHAQCVLCKKILSNSSLAPSKLRRHLETKHAAYKDKDISFFKQHLDSPENNKPPTPKIVNTDNESATEASYNVSYHIALSGEAHTIGELLIKPCAKDVVMRMFDEQYSKKIDAVQLSNSTVARRIKDLAADIEEELVCRLKICDGFSLQLDESADVSGLAVLLVFVRYRFNKSIEEDLLLCESLQSNATGEEIFNCINSFMQKHEIEWEKCVDVCSDASRAMDGKIAEAVTLIKYVAPESTSSHCLLYRHALAVKIMPTSLKNVLDQAVQIINYIKARPHQSRLLKILCEEMGAQHTALLLNTEVRWLSRGKVLVRLFELRRELLVFMDSAFRLSDCLTNSSWLLRLAYLADIFTKLNEVNLSMQGKNVTVFTVFDKMSSLLRKLEFWASSVEEENFDCFPTLSDFLTEINSTVDKDICSAIVQHLRGLRSTLLKYFPVTNDNNTWVRNPFTVTVKPASLVARDYESLIDLTSDSQVKQNFSELSLNDFWSSLIQEYPSIARRAVRVLLPFATMHLCETGFSYYAATKTKYRKRLDAAPHMRIRLSNITPNIKRICDKKTQKHCSH
What are the official names of this protein?
Zinc finger BED domain-containing protein 5, Transposon-derived Buster1 transposase-like protein.
Protein: YCJF_SALDC
Sequence: MSEPLKPRIDFAEPLKEEPTSAFKAQQTFSEAESRTFAPAAIDERPEDEGVAEAAVDAALRPKRSLWRKMVMGGLALFGASVVGQGVQWTMNAWQTQDWVALGGCAAGALIIGAGVGSVVTEWRRLWRLRQRAHERDEARELLHSHSVGKGRAFCEKLAQQAGIDQSHPALQRWYAAIHETQNDREIVGLYAHLVQPVLDAQARREISRFAAESTLMIAVSPLALVDMAFIAWRNLRLINRITTLYGIELGYYSRLRLFRLVLLNIAFAGASELVREVGMDWMSQDLAARLSTRAAQGIGAGLLTARLGIKAMELCRPLPWIDNDKPRLGDFRRQLIGQLKETLQKSKSSPEK
What are the official names of this protein?
UPF0283 membrane protein YcjF.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSRP_PSEPW
Sequence: MKRTAFFISDGTGITAETLGQSLLAQFDSIPFNKFTRPYIDTPDKARTMVQQINAAAERDGMRPIIFDTIVNQDIREILATSNGFMIDIFSTFLSPLEQELTAHSSYSVGKSHSIGGNSNYMERIEAVNFALDNDDGARTHYYDKADLILVGVSRCGKTPTCLYMAMQFGIRAANYPLTEDDMERLQLPAVLKKHHNKLFGLTIDPDRLTAIRHERKPNSRYSSFAQCEFEVREVESLFRRENIPNINSTHFSVEEISAKILVEKGVERRFK
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: Y2283_METFK
Sequence: MKQLGDDAEALAERYLIKQGLVVIARNYRCRFGEIDLVMKQGATIVFVEVRMRSHATFGGAAASIHAAKRQKLILTAEHFLQRHGSAPCRFDAILLSKRDADGIEWIQDAFSA
What are the official names of this protein?
UPF0102 protein Mfla_2283.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: MUTS_BACC7
Sequence: MTQYTPMIQQYLKVKADYQDAFLFFRLGDFYEMFFEDAVKAAHELEITLTSRDGGSSERIPMCGVPYHAAKNYIEQLVEKGYKVAVCEQVEDPKTAKGVVRREVVQLITPGTMMEGRTIDEKENNFLAALTHFEDGSYALACNDLTTGQNTVTLLTGSVEDILLEVYATGSKEIVVDSSFSKDELNKLTETLKMTISYEDATAIPEGLEHLVKNVSQAKLIKAVGRLFNYVIRTQKRSLDHLQPVEIYYTNQFMKIDVHSKRNLELTETLRTKEKTGSLLWLLDKTKTAMGGRMLKQWMERPLIQKERIEERLEMVETFVNDYFLREDLKEKLKEVYDLERLAGKVAFGNVNARDLLQLRRSLLQVPAILEAISLLDNAYAARLIQGADPCESLTELLGRSIQENPPLSIKDGDIIKDGYNDKLDQYRYVSKNGKTWIAELEKRERDITGIKSLKIGYNRIFGYYIEVTKANLGALPEGRYERKQTLANAERFITDELKEKETLILEAEEKIVQLEYDLFTALREEVKVFIPKLQHLAKVISELDVLQSFATVSEEEQFVKPVLTTKREIFIKDGRHPVVEKVLNGKLYVPNDCIMPENMDVFLITGPNMSGKSTYMRQLALVTVMSQIGCFVPATEAVLPVFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIANASERSLILFDEIGRGTSTYDGMALAQAIIEHIHDQIGAKTLFSTHYHELTVLEDSLDQLKNVHVSAIEENGKVVFLHKIQDGAADKSYGIHVAQLAELPDSLITRAKEVLAQLEGQEEIIIPKRVEVKAQAQEVIPEPVVVKEEPVEIEETKAETEEESQLSFFGGEQSSKKQDKPVLDAKETAVLTQIKKIDLLDMTPLEAMNELYRLQKKLKKG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: 1433Z_CHICK
Sequence: MDKNELVQKAKLAEQAERYDDMASCMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVEQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner.
What are the official names of this protein?
14-3-3 protein zeta.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_METI4
Sequence: MAKEVSAIVRLQIPAGQANPAPPVGPALGQHGVNIMAFCKEFNAATQKEAGNILPVVITIYKDKTFTFVTKSPPASILLKKAANIASGSKEPNRTKVGKVTKAQVKEIVKIKWKDLNASTEEAAMRMIEGTARNMGIEVVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: TRUA_STRSV
Sequence: MTRYKAIISYDGYGFAGFQRQPHARSVQEEIEKTLTRINKGRPVVIHGAGRTDSGVHALGQVLHFDLPEDRDEEKLRFALDTQTPEDIDFISVEQVSDDFHSRYNKHSKTYEFLVDIGRPKNPMMRHYATHYPYPLELGLIEEAIAQLEGTHDFTGFTASGTSVEDKVRTITEAKVRFDAERNFLVFTFSGNGFLYKQIRNMVGTLLKIGNKRMPIEQIQRILAEKDRHLAGPTAGPNGLYLKEIRYEE
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: PI4KA_HUMAN
Sequence: MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDIPY
What is the function of this protein?
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.
What are the official names of this protein?
Phosphatidylinositol 4-kinase alpha, PI4-kinase alpha, PI4K-alpha, PtdIns-4-kinase alpha, Phosphatidylinositol 4-Kinase III alpha.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Localization to the plasma membrane is mediated by the PI4K complex and association with EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B) (PubMed:23229899). Localization to the plasma membrane is regulated by TMEM150A (PubMed:25608530).
Protein: RL20_POLAQ
Sequence: MPRVKRGVTARARHKKITDAATGYRGRRKNVFRIAKQAVMRAGQYAYRDRRNKKRVFRALWIARINAAVRQHDMTYSVFMNGMKKAAIELDRKVLSDMAIADKAAFAALVTRIKSVVNAAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: EUTR_ECOLI
Sequence: MKKTRTANLHHLYHEPLPENLKLTPKVEVDNVHQRQTTDVYEHALTITAWQQIYDQLHPGKFHGEFTEILLDDIQVFREYTGLALRQSCLVWPNSFWFGIPATRGEQGFIGSQCLGSAEIATRPGGTEFELSTPDDYTILGVVLSEDVITRQANFLHNPDRVLHMLRNQSALEVKEQHKAALWGFVQQALATFCENPENLHQPAVRKVLGDNLLMAMGAMLEEAQPMVTAESISHQSYRRLLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELISPWSQSMTVKDAAMQWGFWHLGQFATDYQQLFSEKPSLTLHQRMREWG
What is the function of this protein?
Activates the transcription of the eut operon.  Also positively regulates its own transcription.  Probably binds ethanolamine and vitamin B12 as effectors.  Competes with ethanolamine ammonia-lysase (EAL, the first enzyme in the EA degradation pathway) for adenosylcobalamin.
What are the official names of this protein?
HTH-type DNA-binding transcriptional activator EutR, Ethanolamine operon regulatory protein.
Protein: DUS7_MOUSE
Sequence: MKNQLRGPPVRAHMSTSGAAAAAAAGGTRAGSEPGAGSGSGAGIGAGATTGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSGSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHAPSEQLYFSTPTNHNLFPINTLEST
What is the function of this protein?
Dual specificity protein phosphatase (PubMed:27783954).  Shows high activity towards MAPK1/ERK2 (By similarity).  Also has lower activity towards MAPK14 and MAPK8 (By similarity).  In arrested oocytes, plays a role in meiotic resumption (PubMed:27783954).  Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (PubMed:27783954).  May also inactivate PRKCA and/or PRKCG (PubMed:27783954).  Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (PubMed:27783954).
What are the official names of this protein?
Dual specificity protein phosphatase 7.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADM_METTP
Sequence: MRRGFYIGRFQPYHMGHHLVLEQISREVDEIIVGIGTAQISHTVTDPFTAGERIAMIYGALRELGRWFYIIPLPDINRNAVWVSHVKSMTPPFEVVYSNNPLVVELFMEAGMEVRRPPMYRREVYSGTVIRRLMIEGGDWRQLVPDAVAKVIDEIKGVERLRNISKKDFA
What are the official names of this protein?
Nicotinamide-nucleotide adenylyltransferase, NAD(+) diphosphorylase, NAD(+) pyrophosphorylase, NMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the archaeal NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UTP25_DANRE
Sequence: MGKRRRGKQEIDNLTKKQKKHLKEFGEQHPFHDKVVERPEKTQILRLPDSPQRPEPDSEDDSDAEQPSAYQKLLSTMIQGDEDDVESEDEESEEEDNEEEAEVEGDSEEEVEDTDEEDGNDAEEVLEDKVEETSDKLQKKHPEKTNGDVEENEEAEMEGEFTDKKNEAAFCLETNMPAEGEENTAQQEQDEDMFVKHQEIELSEEEVGRISQGSKVKTQVKWAKLGVLQCMCPLERFPAIGQASSAPLPPIHKTLEANWHLLNLPFGAATDVTELQKEMLGLMGTYRDLYLANLSPLKEAKEVRSAYCLHALNHVLKANSRVLRNNAKLKESKNGDEDFRDQGLTRPKVLILVPFRDGALRVVQTFMTLLEPKGKKTDASNKKRFKEEYGEETDEKPPNLQRPDDYHAVFSGNIDDHFRIGMSILRHSMRLYAPFYSSDIIIASPLGLRTVLGAEGEKKRDHDFLSSIELLIVDQADVFLMQNWEHLLHVLEHLNLQPLDSHGVDFSRVRMWNLNNWAAYYRQTLVFSAIQEPQITNILTKHCHNYRGQVCSKTIPKIGSICQVLVQLPHVFQMFHSDSFMDQDARFQFFVDKILPQYRDSVMSHTFIYVPSYFDFVRLRNYLKKEDVSFANISEYSQRSEVSRARHYFQKGEKQFLLFSERFHFYKRYTIKGIHNLIFYGLPTYPHFYSEVCNMLQAGVREGGASVSFTCTALYSRYDVHRLAAITGADRAAQMLQSKKTTHLFITGEEKST
What is the function of this protein?
Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (PubMed:28263972).  Essential for embryonic development in part through the regulation of p53 pathway.  Required for the expansion growth of intestine, liver and exocrine pancreas, but not endocrine pancreas.  May not play a major role during the early stage of endodermal organogenesis.  Also involved in the sympathetic neuronal development (PubMed:28263972).  Triggers the degradation of p53/TP53 and Delta113p53 isoform in a ubiquitination pathway independent way (PubMed:23357851).  Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329).
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25 homolog, Digestive organ expansion factor, UTP25 small subunit processor component.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.