Protein: CITS_MONRU
Sequence: MIDSTSHSNLRSKAFIFGPQDLSFDVRSFNKLHSQLQNHQWVLDALASLPKLWDNFAASDQKVQQSNTGKLLENLNAWISSGVAPEEAFPLPNVLLSPLVVIGQLVEYMTFLKAAFPDLGKKHDLPISIKEDTETFGLCTGTLCAFAVACSSNIADIQHYGAVAARLAMLVGAIVDTEEVLSDPEGKSVSFSASWNSAEFSDSFTHVLETFPDAYVSVIVDQRRATLTASKKTAPAIIERLKQEGAHVTSIALSGRFHWKKHQDAVSSLIQFCGLDPDLQLADATKMLLPSRSSSDGQYITTGKLHELALRAILLEQSEWYKTCRISYLSKFIMDDAAVICFGPERCMPPTLARKLGPRLTYVSEIDISSSRVPGQLLGGTQKLNLTDLPDERIAVIGMACRLPGAEDHEGFWEILKTGQSQHREVPEDRFGMATAWREADKRKWYGNFIDNYDTFDHKFFKKSPREMASTDPQHRLMLQVAYQAVEQSGYFRNNGTNRRIGCFMGVGNVDYEDNIACYPANAYSATGNLKSFLAGKISHHFGWTGPSLTLDTACSSSSVAIHQACRSILSGECNGALAGGVNVITSPNWYHNLAGASFLSPTGQCKPFDAKGDGYCRGEGVGAVFLKRLSSAIADGDQVFGVIASTKVYQNQNCTAITVPNAISLSELFTDVVRQARLEPKDITLVEAHGTGTAVGDPAEYDGIRAVFGGPIRSDVLSLGSVKGLVGHTECASGVVSLIKTLLMIQQGFIPPQASFSSINPSLNAKAEEKIEISTRLKPWDAPFRAALINNYGASGSNASMVVTQPPNLTETPSTPLPGKSYPFWISAFDQQSLQSYVRRLRQFLEKHAADKNLSVANLSFQVACQSNWSLPQALVFSASTKEELNRALASFEKGSTDFPSVQLPDPKPVILCFGGQVSTYVGLDQEVYNSTAILRHYLDQCDAMCLSLGLQSIYPAIFQRSPIEDIVQLQTALFAMQYSCAKAWIDSGLKVASVVGHSFGELIALCVSNAVSLKDAVKMISGRARLIKERWGADKGSMIAVEADLSDVEALLAKVKSQMGSETGLAIACYNASKSFTLAGPTKDVDHAENLLKNDPDFSGIRYKRLNVTNAFHSVLVDALIDDLESLGQGIRFKEPTIKLERATEQESTSTLNANYVATHMRKPVFFAQAVKRLSDKFPVAIWLEAGSNSTITAMASRALGTSNSSFQAVNITSEGAFRFLCDTTVKLWKEGQKVSFWAHHRLQTPMYTPVLLPPYQFEKSRHWMDLKVPPKPEASVQVAEQTAIIEAPKGLTTFVGYQDASQRSVRFRVNVTTEKFNRLLSGHIMANAAAVCPGMFQVEIALDALTSLRPEFQARSFIPELHDLRHYQPLVRDESRAVWIEAHCPNAEGLVWNWKLTASDDKGSGSVTHTSGTITFQAADSVQVKSEFEKLRRLIGRKRCLQLLDSNVADDILQGRNIYRAFTEVIDYKEIYRHVTKIAGRDNESAGRVIKTYDGETWLDTVLTDCFCQVAGIFVNLMTTKIDLSERGIFICDGIDRWLRAPNAGSNNTPSQVYEVFALHHCESDSKYLSDVFAFDAREGSLVEVALGISYQKVSISGIRRVLSKGMPAGLQPQVPTSPAAVAAIKTVSPPPVADSPLVDGSSTAVSGTPPTKKAPKAPSVDITGKMREIICNLSGLEPDEVKDDSDLVELGIDSLMSMELAREVDLAFKTTIDVTQLIDVTDFRSLVECMQRILGIDNQEDNTYLAEGLNGHEGVVTNGNAYHVNGTNGVVNGNGVLFPELGGSILPKSAILDAFRIAKEATDDFILNGQLGTYYNEVMPRSTELCVAHIVNAFEQLGCPIRSAAAYQRLERVPYLPKHERFMNLIYGLLEEARLIDINGSEITRTSVPVSTKSVETMLEELLHDEPLHAAEHKLTSLTGSKFADCITGKEDGLQLIFGSPEGREIVTDVYAKSPINAVWIQQAEFFLEQLVKRLPNTGEPLRILEMGAGTGGTTVKMLPLLERLGVPVEYTMTDLSSSLIAAARKRFKKYPFMKFKVVNIESPPDPQLVHSQHIILATNCVHATRNLEISTRNIHRILRPDGFLLLLEMTEQVPWVDFIFGLLEGWWLFEDGRRHALQPATHWKKILTSVGYGHVDWTEGTRPEANIQRLIIALASEPRYDHTPQSLQPPVQVPLTDIAGRQEIIDTYIREYTEDFRALPIPGIQQAVMPAPTGHCVLVTGATGSLGSHVVGYLSRLPNVHTVVCLNRRSTVPATIRQEEALKVRGISLDDNSRSKLVVLEVETAKPLLGLPVETYQKLVNTATHIVHSAWPMSLTRPIRGYESQFKVMQNLINLAREVAAWRPVPFKFSFQFISSIGVVGYYPLRYGEIIAPEETMTADSVLPVGYAEAKLVCERMLDETLHQYPDRFRPMAVRIAQIAGSTSNGHWNPVEHFAFLIKSSQTLKALPDFDGSLSWCPVDDVSATLGELLISNTTPYSIYHIENPSRQQWRKMVKTLAQSLDIPRDGIIPFDQWIERVRNSSASINDNPARQLLEFFDQHFIRMSCGNLILDTTKTREHSATLRERGPVGPGLVEKYISAWKTMGFLD
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the mycotoxin citrinin, a hepato-nephrotoxic compound to humans due to inhibition of respiration complex III (Ref. 1, PubMed:29189834).  The pathway begins with the synthesis of a keto-aldehyde intermediate by the citrinin PKS (pksCT also named citS) from successive condensations of 4 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit (Ref. 1, PubMed:29189834).  Release of the keto-aldehyde intermediate is consistent with the presence of the C-terminal reductive release domain (Ref. 1).  CitA collaborates with citS by catalyzing the hydrolysis of ACP-bound acyl intermediates to free the ACP from stalled intermediates (PubMed:29189834).  CitB then catalyzes the oxidation of the C-12 methyl of the ketone intermediate to an alcohol intermediate which is further oxidized by the oxidoreductase citC to produce a bisaldehyde intermediate (Ref. 1).  The fourth catalytic step is catalyzed by the citD aldehyde dehydrogenase (Ref. 1).  The final transformation is the reduction of C-3 by citE to provide the chemically stable citrinin nucleus (Ref. 1).  CitE appears highly selective for its substrate as its presence in any context other than a full complement of citS and citA-D does not result in observable new compounds (Ref. 1).
What are the official names of this protein?
Citrinin polyketide synthase, CitS, Non-reducing polyketide synthase citS.