PharMolix/UniProtQA huggingface dataset:
Protein: CH603_PSYIN
Sequence: MSAKAIKFNHHAREKMLKGVNILADSVKVTLGPKGRNVVIAQKYSRPIITKDGVTVAKEIELIDPFENMGAQLTKEVAFQASDSAGDGTTTATVLTQAIVNEGVNAISANMNPIDLKKGIDKCLHYALLELNLLSQNCDNLEKAEQIATISANGEEQIGKLIAQAMERIGTDGVVSVEDAQGYDDELIFKEGLAFDRGYLSPYFINNHEKSTVELNNPSILLLDDKLTHMEDLLPLLEKLANNRNPLLVIAEDINNEVLSRIIGNNMKNNLKVTVIKSPAFGSRRTEILQDLAIYTGGTVISPEIGMDLSEVDTDKLGNASKIIITDSNTTIVHGEGDPQLIMQRIKQLNSQLLNSSSEYDQKKLAERVAKLSGAIAIIKVGAATEVAMKEKKDRVEDALHATKAAIKEGIVPGGGVAYIRIAQTLASLEGDNPDQSFGIKILLKAMESPLKQIAKNAGNEPVEVLSTIKKQTGNFGFDAKNDRYGDMMEFGIIDPTKVTRCALEFAASIASLILTTEVMVADMEDNNANHANHDHAHSLNCSH
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 3, 60 kDa chaperonin 3, Chaperonin-60 3, Cpn60 3.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_SHEPC
Sequence: MSLSTEAKAKILAEFGRGENDTGSTEVQVALLTAQINHLQDHFKEHIHDHHSRRGLLRMVSARRKLTAYLKRTDAERYTALIQKLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: ACP_PORGI
Sequence: MSEVEKKVIDLVVDKLNVEASEVTREASFSNDLGADSLDTVELMMNFEKEFNMSIPDDQAQEIKTVGDAIDYIEKNLK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHLL_RIPO1
Sequence: MTLTLAVYGKGGIGKSTTSCNISTALAKRGKKVLQIGCDPKHDSTFTLTGFLIPTIIDTLQEKDFHYEDIWPEDVIYKGYAGVDCVEAGGPPAGAGCGGYVVGETVKLLKELNAFDEYDVILFDVLGDVVCGGFAAPLNYADYCLIVTDNGFDALFAANRIAASVREKARTHPLRLAGLIGNRTSKRDLIDKYIEAVPMPVLEILPLIEDIRVSRVKGKTLFEMTESDPSLDYVCNYYLNIADQLLAMPEGVVPNDAPDRELFTLLSDFYLNPQTPVKSQEEELDLMMV
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: Y2187_BACC2
Sequence: MKIYVDADACPVKDVIIFEATNVEIPVTLVTSFSHYSNAEQPKGVETIYVDSGADAADYRIMQLAKKEDLIVTQDYGLASLALAKGCIVLHHKGYKYTNDNIEQLLQTRYLSAMVRKSGKRTKGPKPFTAEDKEKFRALFKSMIAH
What are the official names of this protein?
UPF0178 protein BCG9842_B2187.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: KA102_CENNO
Sequence: VACVYRTCDKDCTSRKYRSGKCINNACKCYPY
What is the function of this protein?
Blocks Shaker B potassium-channels (Kv1. 1/KCNA1 sub-family).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 10.2, Cobatoxin-2, CoTx2.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 10 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GDF8_DANRE
Sequence: MHFTQVLISLSVLIACGPVGYGDITAHQQPSTATEESEQCSTCEFRQHSKLMRLHAIKSQILSKLRLKQAPNISRDVVKQLLPKAPPLQQLLDQYDVLGDDSKDGAVEEDDEHATTETIMTMATEPDPIVQVDRKPKCCFFSFSPKIQANRIVRAQLWVHLRPAEEATTVFLQISRLMPVKDGGRHRIRSLKIDVNAGVTSWQSIDVKQVLTVWLKQPETNRGIEINAYDAKGNDLAVTSTETGEDGLLPFMEVKISEGPKRIRRDSGLDCDENSSESRCCRYPLTVDFEDFGWDWIIAPKRYKANYCSGECDYMYLQKYPHTHLVNKASPRGTAGPCCTPTKMSPINMLYFNGKEQIIYGKIPSMVVDRCGCS
What is the function of this protein?
Acts specifically as a negative regulator of skeletal muscle growth.  May down-regulate muscle-specific transcription factors such as myod and myog.
What are the official names of this protein?
Growth/differentiation factor 8, GDF-8, Myostatin, Myostatin-1, zfMSTN-1, Myostatin-B.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS13_DESVM
Sequence: MARIAGVDLPRGKRVDIALTYIYGIGRTTALQILDVTGVDWSRNIDDLSADEVNEIRKELEQNHKVEGDLRREISSNIKRLMDIGCYRGLRHRRGLPVHGQRTHTNARTRKGPRRGAVGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: YKR7_YEAST
Sequence: MMLVTAHDMPIFAPTCNLMTISHQPLPSHLVRKSSSLHIAASTIHVKFIVRSHVIKMIAGIFLVCECHAKGGANSITASKQSPIIADLYDMKILIVFCLSYTNLIASKVKKQ
What are the official names of this protein?
Putative uncharacterized protein YKL177W.
Protein: NUCS_COREF
Sequence: MRLVIARCSVDYIGRLEAHLPMADRLLMVKADGSVSIHADDRAYKPLNWMTPPCTLTETPITDEDGEEVGVHLWVVENKKGEQLRITVEKIHSELSHDLGVDPGLVKDGVEDHLQELLAEHITTLGEGYTLVRREYPTAIGPVDILCRDADGQTVAVEIKRRGNIDGVEQLSRYLELLNRDELLKPVQGVFAAQEIKPQARTLAEDRGIRCVTLDYQTLRGIESNELTLF
What is the function of this protein?
Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
What are the official names of this protein?
Endonuclease NucS.
What is the protein family that this protein belongs to?
Belongs to the NucS endonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_SHEON
Sequence: MKHIRNFSIIAHIDHGKSTLSDRLIQVCGGLSDREMDAQVLDSMDLERERGITIKAQSVTLEYKAKNGEIYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTALDMNLDVVPILNKIDLPQADPERVAAEIEDIVGIDAMNAVRCSAKTGVGIDDVLEVIVEQIPPPEGNPDAPLQALIIDSWFDSYLGVVSLVRIKHGVLKKGDKFKVMSTGQNHTADRVGIFTPKQTDKTELKTGEVGFVIAGIKEIHGAPVGDTLTLAKNGADKPLPGFKKVKPQVYAGVFPISTDEYENFRDALNKLSLNDASLFFEPESSSALGFGFRIGYLGLLHMEIIQERLEREYDLDLITTAPTVVYEVLMTSGETIYVDNPADLPAINNIEEMREPIVEANILVPKEYLGNVITLCIEKRGTQVNMVYHGNQVAVTYHLPMAEVVMDFFDRLKSTSRGYASLEYNFIRFDPADMVRLDILINGDRVDALAMIIHRSNIRHRGLALVEKMKELIPRQMFDIAIQAAVGSQIIARSTVKALRKDVTAKCYGGDVSRKKKLLNKQKEGKKRMKQVGNVEVPQEAFLAVLKLNE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RR8_SACHY
Sequence: MGKDTIADLLTSIRNADMNKKGTVRVVSTNITENIVKILLREGFIESVRKHQESNRYFLVLTLRHQRRKTRKGIYRTRTFLKRISRPGLRIYANYQGIPKVLGGMGIAILSTSRGIMTDREARLNRIGGEVLCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PCSK4_HUMAN
Sequence: MRPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSVVVPTDPWFSKQWYMNSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRPTPILPLIYIRENVSACAGLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGTAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLRAAACPHHRCPASAMVLSLLAVTLGGPVLCGMSMDLPLYAWLSRARATPTKPQVWLPAGT
What is the function of this protein?
Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity).  In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity).  Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806).  May also participate in folliculogenesis in the ovaries (By similarity).
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 4, Proprotein convertase 4, PC4.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family. Furin subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane.
Protein: PANB_BURM1
Sequence: MTYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFAALLDRAGTDVLLIGDSLGNVLQGHATTLPVSLDDIAYHTACVARAQPRALVVADLPFGTYGTPADAFANAVELMRAGAQMVKLEGGEWLAETIRFLVERSVPVCAHLGLTPQSVHAFGGFKVQGKTEAGAAQLLRDARAIEAAGAQLVVLEAVPTLVASEVTHMLKIPTIGIGAGADCSGQVLVLHDMLGIYPGKRPRFVKDFMQGQPNIEAAVDAYVKAVKDGSFPGPEHSF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WECC_SALTY
Sequence: MSFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDIINRGEIHIVEPALGNVVKMAVEGGFLRATTTPVEADAYLIAVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILESTSPVGATEQMAGWLAGMRTDLTFPQQAGEQADVNIAYCPERVLPGQVMVELIKNDRVIGGMTPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINVWELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVVDQVKAAVTDCLAATDKRASEVKIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVVEPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFKAIPGDAVHQRYVVDTKGVWR
What is the function of this protein?
Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
What are the official names of this protein?
UDP-N-acetyl-D-mannosamine dehydrogenase, UDP-ManNAc 6-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.
Protein: SLX41_CANTT
Sequence: MSPEGEESHAEDNLYFHNTQMQSIHEETLAEESHAQSIQRSISRLSSFKHEDTDSESPIPVQKVIRHIKKTNTNTNTTKTKKRKLKVSKPRKNMSSSESVRQMYGSRKNGEQQGSIDGFLMSRFGDVDGCNESDRSSKLISQGEWESLSKFHEESNEKDKLLRKKIQRYYSEPQEELGEGCGMLSQASADPETKMTKEELESLYDLDSSTVFNQTTISAIGDMSEPTQVSEPCVVILSQTKVQSEASTQEDGADASVQEIKSSVPTQELFSTPEFVPAPLEQPVNKEVCSDQSIVVLEENVQSTQADDSDIVELISDSDPEPEEVSTKVQVLRSIYDSSGPVNDKQPSVASETVESDSTPIVSPVKTPQGTRMHVVQVASSNPSSPIKIVEENTEQQEEVFTDVESIYSTARTSFGTPKHTSPVILLESSDTDCDDNDNDVEPLSSMPMVKTVPKKRMRTTVLQVSAALKVQNYTDEKNNIKLRKIGDDIPVEVPTKDVEYEEIPDSQESVGGEGDNSVSIIEITREVHNNDYTGDESTDLFQVGLNKQDTCEDTSSPVVQIGGVENDILDSSLIEPVPEPESVPVPEEVQEQPQPTAIDKHTATQLREKFQLWGLKPVRGKEKMVEILQGISNFILPEHELLAVADKQELQSCIFMKLDAVIREGRAMYDRILSFEPIRIEELQMMLQSQDYYLELDVLRLYCDSSGITTTNA
What is the function of this protein?
Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX4 1.
What is the protein family that this protein belongs to?
Belongs to the SLX4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LPXK_PSEAE
Sequence: MSFSERLLAAWYQGHPALALLRPLEALYRRVANGRRADFLSGRKPAYRAPLPVLVVGNITVGGTGKTPMILWMIEHCRARGLRVGVISRGYGARPPTTPWRVRAEQDAAEAGDEPLMIVRRSGVPLMIDPDRPRALQALLAEEQLDLVLCDDGLQHYRLARDLELVLIDAARGLGNGRCLPAGPLREPAERLESVDALLYNGADEDPDGGYAFRLQPTALINLQSGERRPLEHFPAGQEVHALAGIGNPQRFFRTLEALHWRAIPHAFPDHATYTAAELAFSPPLPLLMTEKDAVKCRAFAAADWWYLAVDAVPSPAFVAWFDARLEHLLAR
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: IDI2_BACC1
Sequence: MVRAKRKLDHIEYALSTGQSRTHGFHDIDFVHQSLPNSNYDTITCETKIGELSLSSPIFINAMTGGGGEKTLHINEQLAYVAKHHNLAMAVGSQMAALKDESEAASYKIIRKVNPNGIFFANLGSEATIEQAERAVDMIEANALQIHLNVIQELTMPEGDRDFTGVLRRIEKIVLNSKVPVIVKEVGFGMSKETMQQLASIGVTAIDIGGQGGTNFAAVENERRQRMLSYFNNWGIQTATSIVEATSTNNNLSFIASGGIQTALDVAKAIALGANTTAFAGYFLRILMQDGIEKLVDEIDLLHTDLKFIMTALGAKTIEELQSVPLVVKGETYHWLTQRGIDTTHYSRR
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ST32B_MOUSE
Sequence: MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCVERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVLKGSEKASSMAGTKPYMAPEVFQVYVDGGPGYSYPVDWWSLGVTAYELLRGWRPYEIHSATPIDEILNMFKVERVHYSSTWCEGMVSLLKKLLTKDPESRLSSLRDIQSMTYLADMNWDAVFEKALMPGFVPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKHRSRDSTKDSCPLNGHLQQCLETVRKEFIIFNREKLRRQQGHNGQLSDLDGRIGSQTSSKLQDGRNNNILTHTCPRGCSS
What are the official names of this protein?
Serine/threonine-protein kinase 32B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: CPAO_ASPOZ
Sequence: MAVRIARFLGLSTVAYLALANGIDARDTISRDVIILGGGSSGTYAAIRLRDQGKTVAVVERNNYLGGHGETYYTEDNTPLNFGVEGFFNTTVTRNYLERLQVPYGRRDPAPAHEDYVNLNTGQRTEYTPGQLQDREAFAKWVDAISQFGFLDDGVYRIPEPVPEDLISPFADFVKKYHLEDAVYALFSHTSGDVLEMITLYVIQYIGVPHAAALNEGYVRPIEGIAALYKSAGKELGSDVLLETTPEAVQRFEDGVEVIVRSADGTKTLLKGKQLLVTIPPLLENLHGFPLSDQESRLFSKWQYHQYWAALVNDTGLPDDVNIVNVDTERLYGVPEEPFIWRLDNHWAPGYHNIKLVGGSEFGEDEAKAYMYERLDLLHAEGTYATHKPEIVKFASHTPVTMFVSAEEIRGGFYRQLYELQGLNSTFWTGATWASDYSTLLWGYTDEVLDQMASS
What is the function of this protein?
Beta-cyclopiazonate dehydrogenase; part of the gene cluster that mediates the biosynthesis of the fungal neurotoxin cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca(2+)-ATPase with a unique pentacyclic indole tetramic acid scaffold (PubMed:21608094).  The hybrid two module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) cpaS incorporates acetyl-CoA, malonyl-CoA, and tryptophan (Trp) and utilizes a C-terminal redox-incompetent reductase domain to make and release the tryptophan tetramic acid, cyclo-acetoacetyl-L-tryptophan (c-AATrp), as the first intermediate in the pathway.  CpaS catalyzes a Dieckmann-type cyclization on the N-acetoacetyl-Trp intermediate bound in thioester linkage to the phosphopantetheinyl arm of the T domain to form and release c-AATrp (PubMed:19663400).  CpaD then regiospecifically dimethylallylates c-AATrp to form beta-cyclopiazonic acid.  CpaD discriminates against free Trp but accepts tryptophan-containing thiohydantoins, diketopiperazines, and linear peptides as substrates for C4-prenylation and also acts as regiospecific O-dimethylallyltransferase (DMAT) on a tyrosine-derived tetramic acid (PubMed:21608094, PubMed:19877600).  The beta-cyclopiazonate dehydrogenase cpaO then carries out the dehydrogenation of beta-CPA to yield an unstable enimine product, which is captured by intramolecular cyclization to create the pentacyclic fused scaffold of alpha-cyclopiazonate (PubMed:21608094).  Finally, the cytochrome P450 monooxygenase cpaH mediates the conversion of CPA into the less toxic 2-oxocyclopiazonic acid, the end product of the CPA pathway in A. oryza (PubMed:21608094).
What are the official names of this protein?
Beta-cyclopiazonate dehydrogenase, Beta-Cyclopiazonate oxidocyclase, FAD-dependent oxidoreductase cpaO.
What is the protein family that this protein belongs to?
Belongs to the beta-cyclopiazonate dehydrogenase family.
Protein: PSMA3_STAA8
Sequence: MEFVAKLFKFFKDLLGKFLGNN
What is the function of this protein?
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
What are the official names of this protein?
Phenol-soluble modulin alpha 3 peptide.
What is the protein family that this protein belongs to?
Belongs to the phenol-soluble modulin alpha peptides family.
Protein: UVRB_CORDI
Sequence: MGDIERTDARFEVISEYEPAGDQPAAIEELDARLSRGERDVVLLGATGTGKSATAAWLIEQQQRPTLVMAPNKTLAAQLANELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHRATSSLLSRRDVVVVSSVSCIYGLGTPQSYLDRSVVLRVDEEVERDRFLRLLVDIQYDRNDVGFTRGTFRVKGDTVDIIPAYEEVAVRVEFFGDDIDALYYIHPLTGDVIRQVDEVRIFPATHYVAGPERMAKAVEDIKAELRDRLEDLENRGKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHLDGRPAGSAPATLLDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEFGFRLPSALDNRPLKWEEFEQRVGQTVYMSATPGDYELAASGGEYVEQVIRPTGLVDPEIDVRPTRGQIDDLIHEIKQRTTKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTKSLIQTIGRAARNVSGTVIMYADKITDSMQYAIDETERRREKQIAYNKEHGIDPQPLRKKIADILEQVQESKAESTAPSSDAVVVSKTNTSSMPVAELRSLIDDLTTQMGTAARELKFELAGRLRDEIAELKKELRGMEEIGLA
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_XANAC
Sequence: MNAAPTVLQQQAQSLSEAVTQPIPGSRKIFVRGSRADLQVPMREIALTRTPTLFGGEENPPLSVYDTSGPYTDPRVAIDLAAGLAPLRAQWIAERGDTLALDGLSSSFGRGREHDARLDAVRFPARRLPRVARQGANVTQMHYARRGIITPEMEYVAIRENQRLEAVTDASLRKQHPGQAFGASIQQRITPEFVREEIARGRAILPNNINHPESEPMIIGRNFLTKINANIGNSAVSSGIAEEVEKLVWSIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVDGRAEELTWDIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRVTGIVSRGGSIMAKWCLAHHKENFLYTHFEDICQIMKAYDVAFSLGDGLRPGCIADANDAAQFGELETLGELTKLAWQHDVQTMIEGPGHVPMQLIKENMDKQLRECGEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPNRQDVRDGIMAYKIAAHAADLAKGHPGAQVRDNALSKARFEFRWDDQFHLGLDPEKAKEFHDETLPKDAHKLAHFCSMCGPHFCSMKITQDVRDYANEHGVSEAQALSTGMQEKSAQFVAQGAQVYRAT
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: LOLD_PSYA2
Sequence: MSAILKATNINKIYDEGAVSTQVLTGLDLTVNAGERIAIVGTSGSGKSTLLHLLGGLDTPTSGEVWLHGQLLNSMNETERGAMRNKHLGFIYQFHHLLAEFTAVENVAMPLLMRSEVSTAEARQQAIDILNSVGLEHRLAHRPGELSGGERQRVAIARALVTKPSLILADEPTGNLDYDNAQSVFGLLSELQSTMQTALLMVTHDRNLAALADRQLLLRNGHWENY
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NA25_HETCR
Sequence: GNCKCDDEGPNVRTAPLTGYVDLGYCNEGWEKCASYYSPIAECCRKK
What is the function of this protein?
Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process.
What are the official names of this protein?
Delta-stichotoxin-Hcr1d, Delta-SHTX-Hcr1d, Neurotoxins V, RTX-V, Rm5.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type II subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: KERA_BOVIN
Sequence: MASTICFILWVVFVTDTVWTRSVRQVYEASDPEDWTMHDFDCPRECFCPPSFPTALYCENRGLKEIPAIPSRIWYLYLENNLIETIPEKPFENATQLRWINLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQHNKLLDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQVFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDAGLPSSGFNVSSILDLQLSHNQLTKVPKISAHLQHLHLDHNKIRNVNVSVICPSTPTTLPVEDSFSYGPHLRYLRLDGNEIKPPIPMDLMTCFRLLQAVII
What is the function of this protein?
May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
What are the official names of this protein?
Keratocan, KTN, Corneal keratan sulfate proteoglycan 37A core protein, Keratan sulfate proteoglycan keratocan, KSPG keratocan.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: YOTL_BACSU
Sequence: MKKQWKPVDSRLNELMHEYSVSIEDLVECTGLSKQRINDYVGGFKSNMNIGTAMTFADAIGCSIEELYVWNFKERRQLTK
What are the official names of this protein?
SPbeta prophage-derived uncharacterized HTH-type transcriptional regulator YotL.