PharMolix/UniProtQA huggingface dataset:
Protein: MSD3_HUMAN
Sequence: MQNNEIIKPAKYFSELEKSILLALVEKYKYVLECKKSDARTIALKQRTWQALAHEYNSQPSVSLRDFKQLKKCWENIKARTKKIMAHERREKVKRSVSPLLSTHVLGKEKIASMLPEQLYFLQSPPEEEPEYHPDASAQESFAVSNRELCDDEKEFIHFPVCEGTSQPEPSCSAVRITANKNYRSKTSQEGALKKMHEEEHHQQMSILQLQLIQMNEVHVAKIQQIERECEMAEEEHRIKMEVLNKKKMYWERKLQTFTKEWPVSSFNRPFPNSP
What are the official names of this protein?
Myb/SANT-like DNA-binding domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the MSANTD3 family.
Protein: AATC_SCHPO
Sequence: MSDYGFANIEEAKADAIFKLNAQYHQDEDPKKVNMSVGAYRDDTGKPWILPAVKKASKIVEEQASFNHEYLPIAGLPRFTKAAAEVLFRPNPHLLSEDRVASMQSVSGTGANFLAASFIETFYVKHTGAHVYISNPTWPVHRTLWEKLGVTVDTYPYWDAKNRSFDYEGMLSTIKSAPEGSIFLLHACAHNPTGIDPTREQWLSIFESLLSRKHLVVFDIAYQGFASGDLNRDSWALNEFVKYNKDFFVCQSFAKNMGLYGERTGCMHYVAKDASTKNKVLSQLCIVQRNTISNPPAYGARIAAEILNSPQLFAEWEQDLKTMSSRIIEMRKRLRDSLVALKTPGSWDHITQQIGMFSFTGLTPAQVQFCQERYHLYFSANGRISMAGLNNSNVEHVAQAFNHAVRELP
What is the function of this protein?
Plays a key role in amino acid metabolism.
What are the official names of this protein?
Aspartate aminotransferase, cytoplasmic, Transaminase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARB_BRUME
Sequence: MPKRTDIKSILIIGAGPIVIGQACEFDYSGTQACKALKEEGYRIILVNSNPATIMTDPDLADATYIEPITPEVVAKIIAKERPDAILPTMGGQTALNTALSLRRMGVLERYNVEMIGAKAEAIDKAEDRALFREAMKKIGLDTPGSMFANATEIKDEDRKRHEVKRAEVKAQFSGDELDKALDKLETEWQLGEVERKQRYMSHALAKAAQALDVVGLPAIIRPSFTLGGTGGGIAYNRQEFFEIIERGLDASPTTEVLIEESVLGWKEYEMEVVRDHADNCIIICSIENLDPMGVHTGDSITVAPALTLTDKEYQIMRNASIAVLREIGVETGGSNVQFAINPANGRMIVIEMNPRVSRSSALASKATGFPIAKVAAKLAVGYTLDELDNDITGGATPASFEPSIDYVVTKIPRFAFEKFPGSSPILTTAMKSVGEVMAIGRTFQESLQKALRGLETGLTGFDEIAIPNIEEGDEKNAIRAAIGTPTPDRLRMVAQAMRLGLSVEQVHDASKIDPWFLEQIESIVKTEERIREHGLPQDAENLRMLKAMGFSDARLASLTAKDAEDVAKLRADLDVHPVYKRIDTCAAEFASPTAYMYSTYETPFVGQPRSEAEVSDRKKVVILGGGPNRIGQGIEFDYCCCHAAFALGDADYEAIMVNCNPETVSTDYDTSDRLYFEPLTAEDVLEILRVEKQKGTLHGVIVQFGGQTPLKLANALEKAGIPILGTSPDAIDLAEDRDRFQKLLIKLDLNQPKNGIAYSVEQARLVAADLGFPLVVRPSYVLGGRAMQIIHDERGLQAYLLDTVPELVPEDIKAKYPNDKTGQINTLLGKNPLLFDTYLTEAIEVDVDCLCDGKDSLVAGIMEHIEEAGIHSGDSACLLPVHTLSPEIVAELERQTAALATALHVGGLMNVQFAIKDGEIFILEVNPRASRTVPFVAKTVGTPIAKVAARIMAGESLEAAFDAYGGKPQPTARPHIAVKEAVFPFARFPGVDTLLGPEMRSTGEVMGLDYDYALAFAKAQLGAGVELPREGTVFVSVRDEDKERVLGPVRKLASIGFKVMATGGTQKFLEANGVESTKINKVIEGRPHVEDAIRNRQIHLVFNTTDSASAVSDSKSIRRATLMQKLPYYTTMAGAESAAEAIAALKAGSLEVRPLQDYFRS
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: PLK2_MOUSE
Sequence: MELLRTITYQPAAGTKMCEQALGKACGGDSKKKRPQQPSEDGQPQAQVTPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRLLHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDIYKLRHDLKKVSITQQPSKHRADEEPQPPPTTVARSGTSAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQSEEYLLTYINEDRISTTFRLTTLLMSGCSLELKNRMEYALNMLLQRCN
What is the function of this protein?
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition.  Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains.  Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1.  Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome.  Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity.  Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression.  Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively.  Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
What are the official names of this protein?
Serine/threonine-protein kinase PLK2, Polo-like kinase 2, PLK-2, Serine/threonine-protein kinase SNK, Serum-inducible kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, dendrite. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
Protein: EIK1_PLAF7
Sequence: MTSEDKTALCAENILNDIYILTINRNIDIDIIQEGLLRKVMDEEESNSILFLEDSSFSKNDISILNVHLKIEDGKNKYNNYYEFKYADINVTIDFYQKECKYSIEKSNMHKCHYFKMMNKINYITEQKMDFKDSILYLYNTINDKNFFKCPCWLNDNKNIKLNNIINDHQQKKKKKNLYDKSVQVTNDVTNIMVNEIQEQKMKKPIFFDNKNDLNNSDDEFNSAHSSLIKINKLLNVEENDIFHNLKGHVYEEYFDKHEDNKNQKDNIESNIIVKDKKDRANNIISEQMKEDYIKNVEEVLSKHINNNKNNNVEDSVSLYSLDEEISEQIDKQHFFSIDKRQDEISNFIQMEENINDHMNDNINKMGKKKHGKENRVVEDEKYIQDDKKKKRFYRNVNDNIPLTVQLANKGNEICKEIIEMNSRYYRDFFEEKILGCGGFGYVMKVKNKKFNITYALKIIRLSNSKYNTQTNNKHINEKDNNSYIMEEAIMIAKLQHENIVRYYDAWVEENVDFFLYKELQNEFKNIKIKIKNEKMKNEKMKNEKIISGKIKNENIKSENIKSENIKSENIKSENIKSEKVKNLYIEEIKYFWNHYKKNKDPNVNDKYLYILMEYCPGKTLREAIDCGFICRNEKLIWELIKQILKGISYIHDMKIMHRDIKPSNIFLQITDNILIAKIGDFGLTTRIGDTQINPSAGTIHYISPEQLNGEPFNEKADIFSLGVVFFEMFHEPFSTSMERSITLSNLLKGIYPEYMKADNKKFQFLSSLLAINPQERCCAYNLLHESVLFTFEKDFTDIYNLIDNKRNCEEVHTIISTLFDKFEYLNSDKILKKEDFSTFQNAKIFTDDLEMRKKQKIIKKKILISLKKRGAIFILTPIILLNKYYINLENTYMEEYNIYYNINKKKENKINNIYINTNKNKNIDNLIYMLDIYGNSITLRNSFFLSFAEYIYESIDSYNKYNEDNLFYKFYTYGYTYKNQIIKSNKHIKKDTINNNINTTINITTTTCNTTTGTSTNNNNNNNNNNMGNNNIGNNMGNNVSNIISNNNINNHMISNNPFYFYNIYPDENEKMFYCILSSSKNVFGNEELNYLSIFSNADIMVSIYTLYNHINYFNKLLFVWSYIDLLEIILKECLDIPNDISYHLSIDLKKNSTLLVNKSFVMSLLQKYKIKDMSKISDHILSLFYIKCESNKVDDYLNNIYNFVDDLLNKKSSLQLKRNTSITPKEVPYVRSRSNNISTSASKIIKYDIQKNVGTKEKGNQNDNEKKKMQIYSILDRIKKINNFICTNTVINNTCFDLFLNYEESIFCNEVIFYVICESKNKEIIAYGGRFDEIIRNMANEVKYKNHANYKYVYNNIKDIYNNNNNNNNNDNNIMNIKAYGVEIYLDKIYSKVIESNEKISIHLQYNPSTDKSQLFKNFVTSCQQNDFACTSHIIQQPLLNDDYLNYSSTKILIQVYEISNLLIAYDLSKKLLTKNISSYTHLSINNVNIKKKIKNFKPHKIQFFITIKSNNTDNSFDALKPINFDNVVYKIVNYDDQDCNFMDQAELINYLIKYF
What is the function of this protein?
In blood stage parasites, phosphorylates translation factor eIF2alpha in response to amino acid starvation (PubMed:19435497, PubMed:29241041).  During the asexual blood stage, involved in the response to the host hormone melatonin which is used by the parasite to modulate its cell cycle (PubMed:32702775).
What are the official names of this protein?
Eukaryotic translation initiation factor 2-alpha kinase 1, PfeIK1, eIF2alpha kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Protein: TM6S2_HUMAN
Sequence: MDIPPLAGKIAALSLSALPVSYALNHVSALSHPLWVALMSALILGLLFVAVYSLSHGEVSYDPLYAVFAVFAFTSVVDLIIALQEDSYVVGFMEFYTKEGEPYLRTAHGVFICYWDGTVHYLLYLAMAGAICRRKRYRNFGLYWLGSFAMSILVFLTGNILGKYSSEIRPAFFLTIPYLLVPCWAGMKVFSQPRALTRCTANMVQEEQRKGLLQRPADLALVIYLILAGFFTLFRGLVVLDCPTDACFVYIYQYEPYLRDPVAYPKVQMLMYMFYVLPFCGLAAYALTFPGCSWLPDWALVFAGGIGQAQFSHMGASMHLRTPFTYRVPEDTWGCFFVCNLLYALGPHLLAYRCLQWPAFFHQPPPSDPLALHKKQH
What is the function of this protein?
Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (PubMed:24531328, PubMed:24927523).  May function as sterol isomerase (PubMed:25566323).
What are the official names of this protein?
Transmembrane 6 superfamily member 2.
What is the protein family that this protein belongs to?
Belongs to the TM6SF family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein.
Protein: NU5M_NEUCR
Sequence: MYLSIIILPLLGSIVAGFFGRKVGVSGAQLITCLSVIITTGLAILAFFEVGFNNIPVTINLFRWIDSEWYNILWGFQFDSLTVAMLIPVLIISSLVHIYSISYMSHDPHNQRFFSYLSLFTFMMIILVTANNYLLMFVGWEGVGVCSYLLVSFWFTRIAANQSSMSAFLTNRVGDCFLTIGMFVVLWTLGNLDYATVFSLAPYINSDIATIIGICLLIGAMAKSSQVGLHVWLPMAMEGPTPVSALIHAATMVTAGVYLLMRSSPLIEYSSTVLLLCLWLGAITTVFSSLIGLFQQDIKKVIAYSTMSQLGMMVIAIGLSSYNVALFHLINHAFYKALLFLGAGSVIHAVADNQDFRKFGGLKNYLPLTYSVMLIASLSLVAFPYMTGFYSKDFILESAYGQFSFSGVAVYIIATIGAIFTTLYSVKVLYLTFLANPNGYIHFYRHFILYERLYVYVSYTGKEEFYLPKHMSKEINNLPRSVSGEGGFFLSLPLVILALFSIFFGFITKDIFIGLGSNFFIDNSLFIHPIHEIMIDTEFAVPTLFKLLPFIFTISFSLIALVLSEKYPNLVVHFKLSRLGYNLFGFFNQRFLVELFYNKYITNLVLDLGGQITKILDKGSIELLGPFGLEKVLIKWSKDIASLSTSIVTNYALFILVGFILYVFTFISLLEGGLDLNLSLFILLLSLTSSTSSSDSKEGKMIKKAVVSTKNKNIR
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LUXS_HAES1
Sequence: MPLLDSFKVDHTRMNAPAVRIAKTMQTPKGDNITVFDLRFCIPNKEILSSKGIHTLEHLFAGFMRDHLNNEQVEIIDISPMGCRTGFYMSLIGTPNEQQVAEAWLISMQDILNIKNQDEIPELNEYQCGTYTEHSLEEAQNIAQNILHRGVGINKNEDLLLDDNLLNS
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: Y4757_PSEAE
Sequence: MPTLGITDFWTYVLGVVFVILLPGPNSLFVLATSAQRGVATGYRAACGVFLGDAVLMLLSALGVASLLKAEPMLFIGLKYLGAAYLFYLGVGMLRGAWRKLRNPEATAAQAEQVDVHQPFRKALLLSLSNPKAILFFISFFIQFVDPGYAYPGLSFLVLAVILELVSALYLSFLIFTGVRLAAWFRRRQRLAAGATSGVGALFVGFGVKLATATLS
What are the official names of this protein?
Uncharacterized membrane protein PA4757.
What is the protein family that this protein belongs to?
Belongs to the Rht family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KTHY_SHESA
Sequence: MTQASAKFIVVEGLEGAGKSSAIALIRDFIEKHTGLAPVCTREPGGTPLAERIRDLVKIADPSDPLCDESECLLIYAARAQLVANVIKPALAEGKWVLGDRHNLSSLAYQGGGRGLMPLVEAVSNATLKGFKPDLTLYLDLDPKLGLLRAAKRGELDRIEQQAIDFFERARATYLKLASEDERIVVIDASQTMAEVHKDILAVLQAMAW
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: HDOX2_STAA8
Sequence: MFMAENRLQLQKGSAEETIERFYNRQGIETIEGFQQMFVTKTLNTEDTDEVKILTIWESEDSFNNWLNSDVFKEAHKNVRLKSDDDGQQSPILSNKVFKYDIGYHYQK
What is the function of this protein?
Allows bacterial pathogens to use the host heme as an iron source.  Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
What are the official names of this protein?
Heme oxygenase (staphylobilin-producing) 2, Heme-degrading monooxygenase 2, Iron-regulated surface determinant 2, Iron-responsive surface determinant 2.
What is the protein family that this protein belongs to?
Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_BURO0
Sequence: MKASELLQKDQAALNKELADLLKAQFGLRMQLATQQLTNTSQLKKVRRDIARVRTVMTQKANQK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: MURC_STRPD
Sequence: MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNITPDMELIVGNAFRENNKEVAYALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEKGNDFIAYDITRTTNGSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTEIVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVKVEDLAAKIIKPSQVVTVENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_LISMC
Sequence: MNQWEELQESVGFDFKDVELLKQAFTHSSYVNEHRRENVKDNERLEFLGDAVLELTVSNYLFNKYPDMAEGHMTKMRAAIVCEPSLVEFAEAVHFSKYVRLGKGEEKAGGRTRPALLADVFESFIGALYLDNGIDKVVTFLERVIFPKIDAGAYLQTVDYKTQLQEIVQRDRDVLIEYDILGETGPAHNKAFDAQVIVNGQVLGKGSGRTKKQAEQSAAQFAINQLTHR
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_STRSY
Sequence: MSKKLTFQEIILTLQQFWNEQGCLLMQAYDTEKGAGTMSPYTFLRAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLESLERLGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATGPVTSEVTYSLERLASYIQEVDSVYDIEWADGVKYGEIFIQPEYEHSKYSFEVSDQDMLLENFTKFEKEAERALEEGLVHPAFDYVLKCSHTFNLLDARGAVSVTERAGYIARIRNLARVVAKTFVAERKKLGFPLLDEATRAELLKEDAE
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPLE_POPTR
Sequence: MSYLGVGVSPGNVPVYHGMNLKVIDRRVRLAELVLRCVICALGVLAAVLVGTDTQVKEIFSIQKKARFTDMKALVFLVVANGIAAAYSLVQGVRCVVGMVKGSVLFSKPLAWVIFSGDQMMAYLTLSAVAAAVQSASFAKLGQPDLQWMKICNMYGKFCNQVGEGIASALLVSVSMVVLSCISSFSLFRLYGGNKGKDGARW
What are the official names of this protein?
CASP-like protein 2B2, PtCASPL2B2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GBRA2_MOUSE
Sequence: MKTKLSTCNVWSLLLVLLVWDPVRLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKGSVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:27129275).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275).  The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275).  The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (PubMed:27129275).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Cell projection, dendrite.
Protein: Y3711_DICDI
Sequence: MTKIPINIPATSGKIKFGITPSSNKSPSLSPSPSNGQLGGGRGYILEP
What are the official names of this protein?
Uncharacterized protein DDB_G0280323.
Protein: ARGC_SYNFM
Sequence: MLRVAIAGASGYTGFELVRLLDRHPHAELKMITSRVHRGQRLDKVYPALRKHCDLVFEEPDPERLAAEADLVFTALPHRAAMDMIPDLLKGGAKVVDLSADYRFLDAAVYEAWYEPHKTPELLKEAVYGLPELHREEIRNARLVGNPGCYPTSVILAAAPLVAGKLADPRTLIADSKSGVSGAGRGVSLTVHFCEVNDGFKAYKVGEHRHTPEIEQELSRLAGEKLAVTFTPHLVPMSRGILSTVYATVIQGVTPEDISAAYESFYRNARFVRLCRAEMPTTLQVRGSNYCDIGWRLDSRTGRAVLIAVIDNLTRGASGQAICNMNIMCGFPEDCGLQDAPWQP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_NOSS1
Sequence: MKVTQEKLPASQIGLEIEITPEITQKTYEQVIKNLSRTVNIPGFRKGKVPRQVLLQRLGKTHIKAAALEELLQDGIEQAIKQESIAAIGQPRLRSSFDDLINSYEPGQPLTFTAAVDVEPEINLVQYTGLEAKAEEIKYDPARVDEVLEKERQELATLIPVEGRSAQIGDVAVVDFKGVIAKAEGDDENAEPEPIPGGDASDFQVELQEDRFIPGFVTGIVGMNPGDTKEVSAQFPDPYVNQELAGKPAIFTVTLKEIKEKELPELNDDFAQEVSDFDTLEALRASLAERYQKEAEDKTKNNQQEALLGELVKHIEVDLPETLIEKEVDAMLTQTAMRLSQQGLDVKKLFTQDIIPQLRERSRPEAVERLKRSLGLQEVAKRESITVTPEEIQARVTELVQQYPDEDIDAERLQTIVENELLSEKIIDWLLANSTVELVPEGSLASQEPEITAPETEAETIEVAAESTTGE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: MATP_CROS8
Sequence: MKYQQLENLESGWKWKYLVKKHREGELITRYVEASAAKEAVDLLLGMENEPVRVLGWIDQHMNPALQNRLKQTIRARRKRHFNAEHQHTRKKSIDLEFMVWQRLAGLAQRRGITLSETIVQLIEDAERKEKYENHMSTLKQDLQALLGKKE
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_ORITI
Sequence: MTENIDTANIDSMKHKTLKRTANRANKEVFFRRRKGCPLSAPDGTAPIITYKDPDLLSKFISECGRVLPARVTNVCRSKQRELTKAIKIARELALLPFVYHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: TVBK2_HUMAN
Sequence: MGTRLLCWAALCLLGAELTEAGVAQSPRYKIIEKRQSVAFWCNPISGHATLYWYQQILGQGPKLLIQFQNNGVVDDSQLPKDRFSAERLKGVDSTLKIQPAKLEDSAVYLCASSL
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 11-2.
What are the subcellular locations of this protein?
Cell membrane.
Protein: LARGN_HUMAN
Sequence: MSAKSKGNPSSSCPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSLEKIKVQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVKCEDPKRVVPTANPVKTNGTLLRNGGLPGGPNKIPNGDICCIPNSNLDKAPVQLLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYNIKNREVHLHSEPVHPPGKIPHQGPPLPPTPHLPPFPLENGGMGISHSNSFPPIRPATVPPPTAPKPQKTILRKSTTTTV
What is the function of this protein?
Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways.  Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions.  Increases mitochondrial mass and respiration.
What are the official names of this protein?
Protein Largen, Mesenchymal stem cell protein DSC54, Proline-rich protein 16.