PharMolix/UniProtQA huggingface dataset:
Protein: PCDA9_PANTR
Sequence: MLYSSRGDPEGQPLLLSLLILAMWVVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVTDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLWSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVLAVDADSGYNAWLSYELQPETASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVESGQAPKSSSRASVGATGPEVTLVDVNVYLIIAICAVSSLLVLTLLLYTVLRCSAMPTEGECAPGKPTLVCSSAVGSWSYSQQRRQRVCSGEGPQKTDLMAFSPGLSPCAGSTERTGEPSASSDSSGKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin alpha-9, PCDH-alpha-9.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: YEGS_ECO7I
Sequence: MAEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQCEGDDIPALGILPLGTANDFATSVGIPEALDKALKLAIAGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGGVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLKSDEDNPNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_LISMH
Sequence: MEIRERILADMQVAETIDAHEEIRKSVEFLKAYLKKNTFLKSFVLGISGGQDSTLTGKLAQMAISEMRAETGDDEYQFFAVSLPYGTQLDESDRQDALNFMEPDNRLTVNIKASVDASVAALAEAGVELSDFAKGNEKARERMKVQYAIAAMHKGVVVGTDHSAEAVTGFYTKYGDGGTDINPLFRLNKRQGKALLKELGCPEHLYLKKPTADLEDNKPALPDEVALGVTYDQIDDYLEGKEVPADAAAKIENWFIKTEHKRHMAITIFDDFWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: RGAPB_DICDI
Sequence: MFSHCEGYRIEGGVTDGETNWNNNFNQNNNNNDNNKVMASIYKQQFYGKPHKTFMSLSSPNGPILVCIKKVGNSSDDFYLLVCTEKGFEEVRANKDSLQKSKTTRSFLKMRPTSLNVITSVRPELTKVPLCKVTDKSIQEELVKVCEPEFNKVIKSALLYCKESQRDDNDMLKNISSNVSQEYNDFLNFLGEKVELKDFSKFNGGLDIKNNSHGTHSIYSQINDVEVMYHVATMLPFFPSDPKQSERRKLISLDRVVIIFNDGSKPMSPNCIKSKSTQIIILIQPIKNFVGNSKTTIGISNDENRVVGEQPSPSLTTTTTTTTTTSPTINSNSPTPSNKIKYRVSISNRDEVPNYGPPLPDPPIFEKDDSFRNFLYQKMVGGAASLRNTPAFTSKNSEKASALINVISKYSTKGMEQI
What is the function of this protein?
Mediates the deactivation of rap1 during multicellular development and is required for normal morphogenesis.  Also required for the correct patterning of specific subtypes of prestalk cells.
What are the official names of this protein?
RapA guanosine triphosphatase-activating protein B.
Protein: RS27_PYRAB
Sequence: MALPRNVIPMPRSRFLRVKCIDCGNEQIVFSHPATRVRCNVCGATLVEPTGGKGIIRAKILEVLE
What are the official names of this protein?
30S ribosomal protein S27e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS27 family.
Protein: Y3289_BORBR
Sequence: MQEIEQRIYLAATYDTKGEEAEYLRQLLRRDGVMVVTVDVATSGQGSPAMVSAQEVAACHPQGAQAVFTGERGSAIVAMALAFERYLAGQRDVGAVLGIGGSGGTALVTPAMRALPVGVPKLMVSTMASGNVAPYVGPSDIAMMYSVTDVAGLNRISRRVLANAAGAIAGAFRQARQPIADDGRPAVGITMFGVTTPCVQHVTAALHDRYDCLVFHATGTGGQSMEKLADSGLLAGVLDLTTTEVCDFLFGGVLACTDDRFGAIARSGVPYVGSCGALDMVNFGALDTVPAACRERLLYPHNPQVTLMRTTAQENARQGAWIAERLNRCEGQVRFLIPEGGVSALDAPGQAFYDEAADAALFQALYDHVRQTDRRRLVRVPCHINDPLFARAAVEQFHEISQ
What are the official names of this protein?
UPF0261 protein BB3289.
What is the protein family that this protein belongs to?
Belongs to the UPF0261 family.
Protein: PQQD_PSEAB
Sequence: MSLPSLDSVPMLRRGFRFQFEPAQDCHVLLYPEGMVKLNDSAGEILKLVDGRRDVAAIVAALRERFPEVPGIDEDILAFLEVAHAQFWIELQ
What is the function of this protein?
Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
What are the official names of this protein?
PqqA binding protein, Coenzyme PQQ synthesis protein D, Pyrroloquinoline quinone biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the PqqD family.
Protein: MENG_MYCLE
Sequence: MSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRATRSALRIGPGQKVLDLAAGTAVSTAELSKSGAWCVAADFSVRMLATGGARKVPKVAADATQLPFSDGVFDAVTISFGLRNIADYQAALREMARVTRPGGQLVVCEFSTPTNALVANVYTEYLMRALPQVARLVSSNPDAYIYLAESIRAWPDQVTLACQLSRTGWASPRWRNLTGGIVALHAADKPVR
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: RL19_ACTP7
Sequence: MSNIIKQIEQEQLKQNVPSFRPGDTLEVKVWVVEGSKRRLQAFEGVVIAIRNRGLHSAFTLRKVSNGVGVERVFQTHSPVVDSISVKRKGAVRKAKLYYLRERSGKSARIKERLGE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: VATB_NATPD
Sequence: MQKEYKTITEISGPLVFAEVDEPVGYDEMVEIETPSGETRRGQVLESTSEFVAIQVFEGTSGIDRNSSVRFLGETLQMPLTEELLGRVLSGSGEPIDGGPEIEPDEEREIVGAAINPTAREYPEEFIQTGVSAIDGMNTLIRGQKLPIFSGSGLPHNELALQIARQASVPEEESGDDEAGSEFAVIFGAMGITQEEANEFMDDFERTGALERSVVFMNLADDPAVERTVTPRMALTTAEYLAFEEGYHVLVILTDMTNYCEALREIGAAREEVPGRRGYPGYMYTDLAQLYERAGRIEGREGSVTQIPILTMPGDDDTHPIPDLTGYITEGQIYIDRNLNSQGIEPPINVLPSLSRLMDDGIGEGFTREDHPDVSDQAYAAYAEGEDLRDLVNIVGREALSERDNKYLDFADRFEEEFVQQGYDTNRDVEETLDLAWELLSDLPKEELNRIDEEAIEEYYVEDEQAAQTAD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: KCY_SHIBS
Sequence: MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGEDVSGEIRTQEVANAASQVATFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLALA
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AKH_MANSE
Sequence: MYKLTVFLMFIAFVIIAEAQLTFTSSWGGKRAMTNSISCRNDEAIAAIYKAIQNEAERFIMCQKN
What is the function of this protein?
This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.
What are the official names of this protein?
Adipokinetic prohormone.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: SUVH1_ARATH
Sequence: MERNGGHYTDKTRVLDIKPLRTLRPVFPSGNQAPPFVCAPPFGPFPPGFSSFYPFSSSQANQHTPDLNQAQYPPQHQQPQNPPPVYQQQPPQHASEPSLVTPLRSFRSPDVSNGNAELEGSTVKRRIPKKRPISRPENMNFESGINVADRENGNRELVLSVLMRFDALRRRFAQLEDAKEAVSGIIKRPDLKSGSTCMGRGVRTNTKKRPGIVPGVEIGDVFFFRFEMCLVGLHSPSMAGIDYLVVKGETEEEPIATSIVSSGYYDNDEGNPDVLIYTGQGGNADKDKQSSDQKLERGNLALEKSLRRDSAVRVIRGLKEASHNAKIYIYDGLYEIKESWVEKGKSGHNTFKYKLVRAPGQPPAFASWTAIQKWKTGVPSRQGLILPDMTSGVESIPVSLVNEVDTDNGPAYFTYSTTVKYSESFKLMQPSFGCDCANLCKPGNLDCHCIRKNGGDFPYTGNGILVSRKPMIYECSPSCPCSTCKNKVTQMGVKVRLEVFKTANRGWGLRSWDAIRAGSFICIYVGEAKDKSKVQQTMANDDYTFDTTNVYNPFKWNYEPGLADEDACEEMSEESEIPLPLIISAKNVGNVARFMNHSCSPNVFWQPVSYENNSQLFVHVAFFAISHIPPMTELTYDYGVSRPSGTQNGNPLYGKRKCFCGSAYCRGSFG
What is the function of this protein?
Histone methyltransferase.  Methylates 'Lys-9' of histone H3.  H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1, Histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, Protein SET DOMAIN GROUP 32, Suppressor of variegation 3-9 homolog protein 1, Su(var)3-9 homolog protein 1.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Protein: ROR2_HUMAN
Sequence: MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA
What is the function of this protein?
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes.  It seems to be required for cartilage and growth plate development (By similarity).  Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073).  In contrast, has also been shown to have very little tyrosine kinase activity in vitro.  May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).
What are the official names of this protein?
Tyrosine-protein kinase transmembrane receptor ROR2, Neurotrophic tyrosine kinase, receptor-related 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RL12_HALVD
Sequence: MEYVYAALILNESDEEVNEENITAVLEAAGVDVEESRVKALVAALEDVDIEEAIETAAAAPAPAAGGSAGGEVEAADDDDEEDAEEEAADEGGDDDGDDDEEADGEGLGALFG
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L12.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Protein: METN_CARHZ
Sequence: MIIIKNLEITYPGKRKVKAVDNVSLEIKKGEIFGIIGLSGAGKSSLLRAINGLVRPTSGEVWVDGVEITRLSSKELLNLRQKIGMIFQHFNLLDSRTVFGNVAFPLEIGGYPREQIKKRVMEVLELVGLLDKAESYPRELSGGQKQRVGIARAIAANPKILLCDEPTSALDPQTTGQILKLLAEINQKLGITIVIITHEMRVITEICDRVAVMDNGRVVEEGVVTDVFLNPWHPITKEFVNTVISKELPEEVLAHARTRRPDREVLLLRFAGNTANEPVVSRIIKETGVELSILYGNIGHLKDVPYGILAVEIFGDENRRDKVRQILHELSVKLEVV
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RBY1B_MOUSE
Sequence: MAETDQPGKIFIGGLNIKTRQKTLQEIFGRFGPVARVILMRDRETKKSRGFAFLTFRRPADAKNAVKEMNGVILDGKRIKVKQARRPSSLESGSKKRPPSFSRTRGASRILKCGRGGRSRARSGPSCEGNLGGDRYTPNFNVSSSGRHFAVKRNPSSKRDGPPSKRSATSAQTRSNTGLRGREPHRREISRNMPRGEPASSRRDEYPLPRDYGQSSNDRKYESTSRGYCDYGNYHSREESASKVFSDHAGYLGGRDRDFSEYLSGNSYRDTYRSYGRFHEAPSARGGNNRYDDYSNSQDGYGGRGEPYISNRSNIYSSDYERSGRQEVLPPPIDREYFDREGRQERGHSPKDGLYSASRESYSSNTKIWGIPWRSWRKQI
What is the function of this protein?
RNA-binding protein which may be involved in spermatogenesis.  Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
What are the official names of this protein?
RNA-binding motif protein, Y chromosome, family 1 member B, RNA-binding motif protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVB_MYCTO
Sequence: MTERSDRDVSPALTVGEGDIDVSLRPRSLREFIGQPRVREQLQLVIEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELGSSLRVTSGPALERAGDLAAMLSNLVEHDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPAELERVLARSAGILGIELGADAGAEIARRSRGTPRIANRLLRRVRDFAEVRADGVITRDVAKAALEVYDVDELGLDRLDRAVLSALTRSFGGGPVGVSTLAVAVGEEAATVEEVCEPFLVRAGMVARTPRGRVATALAWTHLGMTPPVGASQPGLFE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: FRDC_WOLSU
Sequence: MTNESILESYSGVTPERKKSRMPAKLDWWQSATGLFLGLFMIGHMFFVSTILLGDNVMLWVTKKFELDFIFEGGKPIVVSFLAAFVFAVFIAHAFLAMRKFPINYRQYLTFKTHKDLMRHGDTTLWWIQAMTGFAMFFLGSVHLYIMMTQPQTIGPVSSSFRMVSEWMWPLYLVLLFAVELHGSVGLYRLAVKWGWFDGETPDKTRANLKKLKTLMSAFLIVLGLLTFGAYVKKGLEQTDPNIDYKYFDYKRTHHR
What is the function of this protein?
The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor.  This subunit anchors the complex in the membrane and binds a diheme cytochrome b.
What are the official names of this protein?
Fumarate reductase cytochrome b subunit, Quinol-fumarate reductase cytochrome b subunit, QFR cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the diheme cytochrome b FrdC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL22_DESPS
Sequence: MEARAVGKYIRISPQKARLVADVVRGMGVDQAITTLRFMPKKGAVILQKVIESALANATQDDQADVDNLYVKVITIDGGPSLKRIRPRAMGRATGIIKRTSHITVVLDEN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: FPG_RHOPS
Sequence: MPELPEVETVRLGLTPAMEGFRIARAVTNRDDLRFPLQKDFVARLTGQIVTGLGRRAKYLLADLASGDVLLMHLGMSGSFRVVAADGAHTPGEFHHPRSEDRTHDHVVFDMSSGARVIFNDPRRFGFMKIFPRAAIDDEPHLKGLGPEPLGNAFDAVMLARACAGKQTSLKAALLDQRVVAGLGNIYVCEALWRAHLSPKRKAATLANRKNEPTDHALRLTDAIRAVLGDAIKAGGSSLRDHRQTSGELGYFQHSFAAYDREGERCRTDGCGGAVKRFVQNGRSTFWCSGCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: HCP_PORGI
Sequence: MEKKMFCYQCQETAGNKGCILKGVCGKDFSTANLMDLLVFNLKGIAIIMTSMRRAGVKADYRKADKAIMESLFATITNANFDYSSIAKRVEKTFALKAELYSLAFTQGIELPENEAVTMQGKPEEYDRLALSVGILRETDEDVRSLKELTIYGLKGLAAYAEHADRLGYVDEEINAFTERALHDVTMGLLSAEELTALVLETGSFGVKVMALLDKANTETYGNPEITEVNIGVGSRPGILISGHDLKDMEMLLEQTEGTGIDVYTHGEMLPANYYPKFKKYNHFFGNYGNAWWKQREEFETFNGPILFTTNCIVPPKANASYKDRVFTTNATGYPGFKYIESDQHGRKDFSEIIALAKTCQPPTEIESGTIIGGFAHHQVLSIADKVVEAVSSGAIRKFVVMSGCDGRQSGRNYYTEFAEALPSDTVILTSGCAKFRYNKLQLGDIGGIPRVLDAGQCNDSYSLAVIALKLKEVMGLDDINKLPIVYNIAWYEQKAVIVLLALLSLGVKNIHVGPTLPAFLSPNVAKVLIENFGIAGIGTVEEDIRTLIA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZAPC_PANAM
Sequence: MKIKPDDKWRWFYDAEHDRMMLDLADGMLFRSRYARKMLTPDAFTESGFCVDDAALYFTFEEKCRQSPLSSDQRAELVLNALVAARFLKPLMPKSWHFSAHRQPMQPAVGEMVAVTLADSGEQARLLVVENGDNAALCLLAQPALTLAGKGMVLGDAIKVMNDRLQPHQQEKTTRYARAV
What is the function of this protein?
Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ.  Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
What are the official names of this protein?
Cell division protein ZapC.
What is the protein family that this protein belongs to?
Belongs to the ZapC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_CYTH3
Sequence: MEDSYLHKGLRRKLIKILRDKGIQDELVLQAIDRVPRHIFLDNAFLEHAYQDKAFPIGDGQTISQPYTVASQTSLLKLSPGMKVLEIGTGSGYQCSVLLEMGVNVFTIEYHKSLFEKSKKMLQSLGYKAQFFCGDGSEGLARFGPYDRILATAGAPYVPQKLLEQLKVGGILVIPVGDQKTQKMLRLTKVTEKEITQEECGDFRFVPLVGKDGWNAKTNKL
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSCL2_HUMAN
Sequence: MVNDPPVPALLWAQEVGQVLAGRARRLLLQFGVLFCTILLLLWVSVFLYGSFYYSYMPTVSHLSPVHFYYRTDCDSSTTSLCSFPVANVSLTKGGRDRVLMYGQPYRVTLELELPESPVNQDLGMFLVTISCYTRGGRIISTSSRSVMLHYRSDLLQMLDTLVFSSLLLFGFAEQKQLLEVELYADYRENSYVPTTGAIIEIHSKRIQLYGAYLRIHAHFTGLRYLLYNFPMTCAFIGVASNFTFLSVIVLFSYMQWVWGGIWPRHRFSLQVNIRKRDNSRKEVQRRISAHQPGPEGQEESTPQSDVTEDGESPEDPSGTEGQLSEEEKPDQQPLSGEEELEPEASDGSGSWEDAALLTEANLPAPAPASASAPVLETLGSSEPAGGALRQRPTCSSS
What is the function of this protein?
Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:19278620, PubMed:21533227, PubMed:31708432, PubMed:30293840).  In association with LDAF1, defines the sites of LD formation in the ER (PubMed:31708432).  Also required for growth and maturation of small nascent LDs into larger mature LDs (PubMed:27564575).  Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (PubMed:31178403, PubMed:27879284).  Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (PubMed:30970241).  Binds anionic phospholipids including phosphatidic acid (PubMed:30293840).  Plays an important role in the differentiation and development of adipocytes (By similarity).
What are the official names of this protein?
Seipin, Bernardinelli-Seip congenital lipodystrophy type 2 protein.
What is the protein family that this protein belongs to?
Belongs to the seipin family.
Protein: DER_CITBB
Sequence: MKPIIAIVGRPNVGKSTLFNRLVGRRKAMVDDMPGVTRDRNYAEVNRFDVPFILVDTGGFEPETSDRLLQQMREQSRFAMDEADLILFIMDARGGLTPADRDVVDMLRRINKPVFYIINKVDGEKQEAEAGDFYSLGVDHIHTISAEHNRGVGDLMDEVLAAIPYDREKELDEEITRIAVVGRPNVGKSTLVNRLLGYERVVANPTAGTTRDAVDTRFTVNKKPYLLIDTAGIRRKGKTVQKVEKYSVMDALRSIERADVVLIVLNAEEGVTEQDSKIAGYAYEAGRGCIFVVNKWDTLAKDNSSIAKFTEEIRRNFKYLPFAPILFVSAETGQRTGKIIAEVDQVMEQYCKRVTTGELNRVFTQAVDENHAPLSAGRRVKFYFATQVAVKPPSFVVFTNCPEGIHFSYERYIMNRFREAFGFNGTPLKLIFRGRDKKDA
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: RS30_BOVIN
Sequence: KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPNANS
What are the official names of this protein?
40S ribosomal protein S30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS30 family.
Protein: RL22_MARSD
Sequence: MEARAIAKYMRISPRKVRLVAENIKGKPVEEALNILKFTPKKGAEMLSKVLYSAVANAEQIPGVDVDSLCVDIVKVDEGPTWKRIQPRAMGRAYRIRKRTSHITVVVKEM
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.