PharMolix/UniProtQA huggingface dataset:
Protein: RAB8A_MACFA
Sequence: MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSPQGSNQGVKITPDQQKRSSFFRCVLL
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  That Rab is involved in polarized vesicular trafficking and neurotransmitter release.  Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.  Regulates the compacted morphology of the Golgi (By similarity).  Together with MYO5B and RAB11A participates in epithelial cell polarization.  Also involved in membrane trafficking to the cilium and ciliogenesis (By similarity).  Together with MICALL2, may also regulate adherens junction assembly (By similarity).  May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity).  Involved in autophagy (By similarity).
What are the official names of this protein?
Ras-related protein Rab-8A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Recycling endosome membrane. Cell projection, cilium. Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Midbody. Cytoplasm. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP-bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Localizes to tubular recycling endosome. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). Non-phosphorylated RAB8A predominantly localizes to the cytoplasm whereas phosphorylated RAB8A localizes to the membrane (By similarity).
Protein: VPU_HV1RH
Sequence: MQSLEILAIVALVVAAILAIVVWTIVGIEIRKTLRQKKIDRLIDRIRERAEDSGNESDGDEEELSALVEMGHHAPWDVDDL
What is the function of this protein?
Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo.
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: CBP1_CAEEL
Sequence: MDEPPSKKSRADSDYDSGLDALSALESLEAFPTSSKDTDVDNNPSTSAGGSGGPSGSTPHPQGTPQPAPSNNGGFNLQPGQSQPQQPPQNMGGGVNGSVLQELLMNPSQTSNNSPRPQAYPPGQQNAFNRSPMMPNGTPNMMSPPSMGRVPGPSPGGPQPPGPGQPQMRPGQPGMFQGDQQQQMMMGAQGQQFPGMMHRYPYAQGGPPPGAQGMPQGYPGVSRGGPTPGQPMGRGAMMNGAMPRSGPMPTQGRPGIPPNQQAMMQPMMTDRQFMQHGQYGQQRPEFMQQYGRPGGYPMMHQGMMMDSNGQPIRGPNQMMMMSNGHPGMSHGPPNGQPGPQAAAAQHAAQQQAAAQAQAQAAAQQQQQQQREQEAAAAAQRNGAGRATTPGSSMLATHQDPEKRKLIQQQLVLLLHAHKCSQREKENRDFAAKNQPPPHAACTLPHCSTMKEVLTHMTSCNVGRLCHSDTTQTTKKCSVAHCASSRQIIAHWKNCSREDCPVCKPLKRIQDTPLQFSLPDLANLIGVNGNSNGSAEGDGLHQFGSPAMRTGNITNSLFEGFNGNPFQNGPNRGGPRPPGGNGEIPNLPPPDMPDCTKEWHHQVTKDLRNHLVGKLVKAIFPEPNQEAMNDNRLKDLIAYARKVEKEMFESANDREEYYHLLAEKIYKIQKELQEKKNSRLNQGAAAHDQYAIPPSNELAQMLGVEGGRSDVHSEGSSMAVAPSQQNQPWGGAPNSNMHQQIPPNGQVPQVNNSSTFPSSGNSTPNIGASSTVSAMLQPKTEPMDDQNTDSLSSRPPTAIGFGGSSSSTPAPIMNGIVKKEEDPEESSNQAPPSVKDTKDGVAESKPKEQQAKREPTPPPTEDTVFSQEDLIKFLLPVWEKLDKSEDAAPFRVPVDAKLLNIPDYHEIIKRPMDLETVHKKLYAGQYQNAGQFCDDIWLMLDNAWLYNRKNSKVYKYGLKLSEMFVSEMDPVMKSMGYCCAKKLAFTPLSLFCYGAAMCTIAREQQYWVFEQSSTQYNVTVTERYTYCQKCFDALPPEGISLSENPNDRNNMAPKTSFTEQKNSVIDYEPFERCKYCMRKWHRICALHDKKVYPEGFICECCRTAKKYQKPDNKYLASKLPHNKLSTFLEDRVNGFIKKQLQAEAHKYPVIIRTLCVQDKEAEVKAQMKQKYVESNQFPEKFPYRTKAVFAFEIIDGVEVCFFGLHVQEYGSACPAPNARRVYIAYLDSVHFFQPRELRTDVYHELLLGYLDYAKMLGYTMAHIWACPPSEGDDYIFHCHPPEQKIPKPKRLQDWYKKMLEKGVQEGSVVEFKDIYKQARDDNLTTPTQLPYFEGDFWPNVIEDCIREASNEEAQRKVKEDDDDGEDADGGLGGGDSGKKKSSKNKKNNLKKNAKMNKKKAGSITGNEVADKLYSQFEKHKEVFFTIRLVSLQNEPAVLAKPISDPDGLMQSDMMDGRDTFLTKAREEHWEFSSLRRAKYSTLCLAYSLHETDSKGMEYTCNKCSSPAVWHCQSCDDFDLCDGCKPTTQHPHEMEKIKSLIGGGEAGDSAAGGTRYESIQRCIASLVHACQCRDANCRRMSCHKMKRVVQHTKMCKKRINGTCPVCKQLIALCCYHAKHCTRDACTVPFCMNIRQKLAEQKRSQQRRADMMMRRRMEGLQSHVGGAAPTPSTVSNGTPSNAPTPPVSAGPGPAVKGGGVGQVQMQQHQGSHVGGSGPAGMGQPMNSFGGMPGMGLGPNAQNGPGLPGMNPQMNANQSRYMPNGPGLGQSGAPGQQQQPMYSSGMPMQRPGGLGGMNPQQQPQQQQGHPGLQNPGGRPGGVHGMGQNQPVRNNQDMVMNMQMQNQHQQPPPFDSTLQPQIMKINSRLKAAKTEEERETVFSDLKKTPHLFHAWLRMRENQNLVPNRMQGYSQMSMGSSNLQNLQQQQLQQQQAGAMRGGGGFAPGQNNSQPRAPSGQFASMNPSMQQQYPQQQQGWPQQRQQNPGGMQQNANPYNQFQNRQNMMMMPQQQQPHPSNAGGQ
What is the function of this protein?
Acetyltransferase enzyme (By similarity).  Acetylates histones, giving a specific tag for transcriptional activation (By similarity).  May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1 (PubMed:19521535).  In differentiated cells, negatively regulates localization of heterochromatin to the nuclear periphery (PubMed:31118512).  Plays a role in migration of gonadal distal tip cells, where it probably modulates expression of genes involved in integrin-mediated adhesion (PubMed:24811939).
What are the official names of this protein?
Protein cbp-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYL_PROMH
Sequence: MQEQYRPEDIEQTIQEHWEKNNTFKVTEDNNKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVISRYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYENINYMKGQLKKLGFGYDWDREVTTCTPEYYRWEQWFFTKLYEKGLVYKKTSAVNWCPHDLTVLANEQVIDGCCWRCDTPVERKEIPQWFIKITDYAEELLNDLDTLDEWPEQVKTMQRNWIGRSEGVEITFDVADSDDTMTVYTTRPDTFMGVTYVAVAAGHPLAQKAAQNNPEIQHFIDECRNMKMAEAEMATMEKKGIATGLYAIHPLTQEKVAIWVANFVLMEYGTGAVMAVPGHDERDWEFATKYGLPIKAVIADAEGNQPDLSTGALTEKNSLINSGEFSGLDNQAGFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMATLEDGSVVPVPDDQLPVILPEDVKMDGITSPIKADPEWAKTTINGQPALRETDTFDTFMESSWYYARYTCPDYDKGMLDPKAANYWLPVDWYIGGIEHAIMHLMYFRFFHKLMRDAGLVNSDEPAKRLLCQGMVLADAFYYTGEDGARHWVSPAEAIVERDEKNRIIKATDSAGHELTYAGMSKMSKSKNNGIDPQTMVERYGADTVRLFMMFAAPPELTLEWQESSVEGANRFLRRLWRLVHEHTEKGTTQSLDLATLTTEQKDLRRDLHKTIAKVSDDVGRRLAFNTAIAAIMELMNKLTRAPQETEQDRALMQEALEAVVRMLSPIIPHACFVMWQALGGKEDIDVAPWPVADEEAMVDDTKLIIVQVNGKVRGRITVPANSEKDYVQEMATKEYSVAKYLENVTVRKVIYVPGKLLNIVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFHB_BACSU
Sequence: MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAGYSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKAGILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTGIWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSPYSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVKVNMTGTAVYSETRILKI
What are the official names of this protein?
Uncharacterized isomerase YfhB.
What is the protein family that this protein belongs to?
Belongs to the PhzF family.
Protein: RL35_BORDL
Sequence: MPKMKTCKSARKRYAFTSKGKVKYKKQNLRHILTKKSAKRKRNLGKSGLVSNVEVKRIKTLLPYV
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: METE_AQUAE
Sequence: MVKTYAFGFPKLGEKREFKRLLENYWKGKISQEELIKGMEELNLWRANLYRENVEIIPSNELSYYDFMLDTTVMVGAIPSRFGEYRGLDTYFEMARGKNALELTKWFNTNYHYLVPELEGENFKLLINRPLEDYKFFKEKGINTVPHVIGLFTFLKLSKAPKRVEEEGLPVIILEKLDTKERLEKFTKALLPVYKELLESLKNEGVNRVHFEEPALVTDLEDYDWEILNEIYSELSKVGVDLGILTYYDSVSDYDKFVNLPVKALHFDLVSNEENLKNIKEKGFPEDKELIAGIINGRQPWRANLREKVKLLEELLKVSANLVVSNSCPLYHLPVTVEPEDELPEGLKERLSFAKEKLREIRLIKEALEGKEEALREVESSEKVMTAVFAQNPEVRRRLASLSEKDFQRELPYKERDKIQRDILKLPLFPTTTIGSFPQTEDVRKMRTAYRTGKISEEEYKNFIKQKIKYAIEVQEDIGLDVLVHGEFERSDMVEYFAIKLDGIATTKHGWVLSYGSRVYRPPIIYGDVSRPAPMTLEEITYAQSLTNKPVKGMLTGPVTILNWSYYREDVPKREIAYQIALALLDEVKDLENAGIKVIQIDEPAFREGAPLKKRDWPEYFDWAVKAFRLASRAKPETQIHTHMCYSEFNEIIEYIYQMDFDVISIEASRSKGEIIEVFEKFKGWDRQIGIGVYDIHSPAIPTKEEMKAIMLRAMKVLPKELLWVNPDCGLKTRRWEEVIPALRNMVDMAKELREEVGVKV
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: RL32_SYNP6
Sequence: MAVPKKKTSKSKRDKRKATWKRKAALQAQRALSLGKSVLTGRAKGFVYPAQDEEETEE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: DF194_ARATH
Sequence: MAMKSVSNFAIFLILFLVTSEISEIEAKDKECLKGYIDAPLSYCMARIYPSLCYRNCRFYKGAKGGKCDGLKCFCDFCSDKPF
What are the official names of this protein?
Defensin-like protein 194, Trypsin inhibitor ATTI-3.
What is the protein family that this protein belongs to?
Belongs to the DEFL family. Protease inhibitor I18 (RTI/MTI-2) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ELTP_MYCS2
Sequence: MMSRESQPGLHRQLSRRNMLAAMGLAGAAAVSLPVLSACGVGGRTNAPNGASEVTGGFDWRKASGSTINILQTPHPYQQSYQPLLKEFTELTGINVNVDLVPEADYFTKLNTELAGGTGKHDAFMLGAYFIWQYGPPGWIEDLNPWLQNSSATNAEYDFEDIFEGLRTSTRWDFELGNPLGTGGQWAIPWGFENNVVAYNKAYFDQRGITKLPDNFDDFIQLAIDLTDRSENRYGIATRGSKSWATIHPGFMTQYVREGAVDYTFDGTDLVAEMDSDKAVEFTRKWIEMQHKAGPTSWTTYDYPNATGDLGDGTAMMVYDADSATYPKNKPGASAQAGNLGWYPGPAGPDGNYKTNLWTWTWAMNANSRNKLPAWLFIQWATGKESMNKAVEGGIYADPVRQSVFDTTFKRIAADQHGYLETFETVIGSSKIQFTPQKKFFDTTKDWAVALQDIYGGDDAASRLRSLAKTNTSKVNL
What is the function of this protein?
Part of an ABC transporter complex involved in erythritol/L-threitol import.  Binds erythritol and L-threitol.  Functions in the transport for the degradation pathways of erythritol and L-threitol, that allow M. smegmatis to grow on these compounds as the sole carbon source.
What are the official names of this protein?
Erythritol/L-threitol-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
Protein: ARADA_AZOBR
Sequence: MSATKPRLRSTQWFGTNDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHFRKLAEHVKRGISEAGGFPVEFPVFSNGESNLRPSAMLTRNLASMDVEEAIRGNPIDAVVLLAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKNIGSGTAVWQLHEALKAGEIDVHHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVALPHNAAIPAVDSRRYVLAHMSGIRIVEMALEGLVLSKILTRAAFENAIRANAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIGRDTPTIVDLMPSGRFPMEEFYYAGGLPAVLRRLGEGGLLPNPDALTVNGKSLWDNVREAPNYDEEVIRPLDRPLIADGGIRILRGNLAPRGAVLKPSAASPELLKHRGRAVVFENLDHYKATINDEALDIDASSVMVLKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGTAYGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGTLHLDITDDELHRRLSDVDPTAAPGVAGQLGKGGYARLYIDHVLQADEGCDLDFLVGTRGAEVPSHSH
What is the function of this protein?
Catalyzes the dehydration of L-arabonate to L-2-keto-3-deoxyarabonate (L-KDA).  Is involved in a degradation pathway of L-arabinose that allows A. brasilense to grow on L-arabinose as a sole carbon source.  To a lesser extent, can also use D-xylonate as substrate, but not D-galactonate, D-arabonate, and D-gluconate.
What are the official names of this protein?
L-arabonate dehydratase, L-arabinonate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: PLP4_ARATH
Sequence: MFKNNKPPKYGNLVTILSLDGGGVRGIIGGVILANLEKHLQEIDNDESVRLADYFDVIAGTSTGGLMTAMLTAPNDSGRPLYAAKDIVPFYLEESPKIFYGSKWWDPSALWALFRPKYNGEYLHTRLGEILGETKLDQTLTNVVIPTFDIKKLQPTIFSSYHASVDPSLNAKLSDICIGTSAAPFYLPPYKFPENDKMRTFNLIDGGVTANDPTLVGMTAMSRKSIIKHPDMDGFKPLEYEKYIVISIGTGSAKREEYYSAVEAAKWGFENWAYNWKHKTTPILDIIFESSRDMVQYHTSVLFQALESEDNYLRIDADTLKKDEVFMDDSETLNLENLKNIGEKLLDTNVMRMNLDTYTYEPIPKTVNNDQELKRFAKILSDEKKLRNKTFKTMIDDSSNS
What is the function of this protein?
Possesses non-specific lipolytic acyl hydrolase (LAH) activity.  Hydrolyzes phospholipids as well as galactolipids.  May play a role in disease resistance (By similarity).
What are the official names of this protein?
Patatin-like protein 4, AtPLP4, Patatin-related phospholipase A IIepsilon, pPLAIIe, Phospholipase A V, AtPLA V.
What is the protein family that this protein belongs to?
Belongs to the patatin family.
Protein: DEF_YERPE
Sequence: MSVLQVLHYPDERLRKIAAPVKEVNGEIQRIVDDMFETMYAEEGIGLAATQVDVHQQIIVIDISENRDQRLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELETDGLLAICIQHEMDHLIGKLFVDYLSPLKRQRIRQKLEKMAKLNARAN
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: TKTN_METJA
Sequence: MDNNLEIKDLEKIAKKVRYNIVKMVGLAKSGHPGGSLSATDIIVALYFKLMNYSPDNPYKKDRDRFVLSKGHAAPALYAVLSELGIIEEEELWKLRRLEGKLQGHPSMDTPGVEICTGSLGQGFSAAVGMALGCRLDKLNNYVYVLLGDGECQEGIVWEAAMAAAHYKLDNLIAFIDRNKLQIDGCTEDVMSLGDIKAKFEAFGWDVFEIDGHNFEEIINTVEKAKSMKNGKPKMIIAYTVKGKGVSFMENNVAFHGKAPNEEQLKQALEELSE
What are the official names of this protein?
Putative transketolase N-terminal section, TK.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: HKM3_ASPHA
Sequence: MTKLDSPQFEPFELTAADYAFPMFYAGCTLSFRLKSPEMGIPVLQTAVERITAHLPFLTGIVIPSAVKDGVMEVHPAACGQSGLEDPQCRVRRLPHLCLPPKTASASANKKHGSGMTYDRNECLIVAPLEAATAAQQHPVIRFQINVLADGIIFTLFANHMVIDGTGLGIITEMLASCCQTADNTGSVPELAGAIDREARTRAMLGTIGRREREKVQFEPVAAESAAPDGHQEVHDASLVDCNFRLSADKIRRIRERAQELGIASASEDDIVTAVLWLCMSEFRSHSGAGKEISACTLLRMVNVRRRFHPAVPDNYLGNCYIMIEETLPTTDLSGGAAQASTEEDFLRLIGVVASVLRSRLNRVDDQYVRDHLAQFTHAGDWAHTTIHEPDVAVTSLRGMSVYSLDFGSVLSGIVDFETLPYMNPDGVCTIKPRRVIDPSWEVAVTLSREDMDRLRKNELFRWLVVGESYLHIFQSAQQVTTFA
What is the function of this protein?
O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines (PubMed:33242032).  The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine called xenocockiamide A (Probable).  Xenocockiamide A is then converted to hancockiamide D via a series of hydroxylations and O-methylations (Probable).  The tyrosinase hkm6 may catalyze an aromatic hydroxylation, then the 2-oxoglutarate-dependent Fe(II) dioxygenase hkm4 and the FAD-dependent phenol hydroxylase hkm7 may catalyze consecutive hydroxylations to install 2 more hydroxy groups, and the methyltransferase hkm8 probably catalyzes two methylations using 2 molecules of S-adenosyl-L-methionine (SAM) (Probable).  The NRPS hkm11 activates and transfers trans-cinnamate supplied by the PAL hkm12 to hancockiamide D and produces hancockiamide A (PubMed:33242032).  NRPS Hkm11 has the flexibility to tolerate the bulky hancockiamide G as a substrate and the absence of the acetyl-transferase hkm3 opens up the opportunity for hkm11 to introduce a second N-cinnamoyl moiety (PubMed:33242032).  The cytochrome P450 monooxygenase hkm5 catalyzes the methylenedioxy bridge formation, converting hancockiamide A into hancockiamide G (PubMed:33242032).  Hkm5 can also convert hancockiamide B into hancockiamide C, and hancockiamide D into hancockiamide H (PubMed:33242032).  The N-acetyltransferase hkm3 finally transfers an acetyl group to 1-N of piperazine, converting hancockiamide A into hancockiamide B and hancockiamide G into hancockiamide C (PubMed:33242032).
What are the official names of this protein?
O-acetyltransferase hkm3, Hancockiamides biosynthesis cluster protein 3.
What is the protein family that this protein belongs to?
Belongs to the fumigaclavine B O-acetyltransferase family.
Protein: NCLN_MOUSE
Sequence: MLEEAGEVLENVLKASCLPLGFIVFLPAVLLLVAPPLPAADAAHEFTVYRMQQYDLQGQPYGTRNAVLNTEARTVDADVLSRRCVLMRLLDFSYEHYQKALRQSAGAVVIILPRAMAAVPQDVVRQFMEIEPEMLAMETVVPVYFAVEDEALLSIYEQTQAASASQGSASAAEVLLHTATANGFQMVTSGAQSQAVSDWLITSVEGRLTGLGGEDLPTIVIVAHYDAFGVAPWLSLGADSNGSGISVLLELARLFSRLYTYKRTHAAYNLLFFASGGGKFNYQGTKRWLEDSLDHTDSSLLQDNVAFVLCLDTVGRGSHLRLHVSKPPREGTLQHAFLRELETVAAHQFPDVSFSMVHKKINLADDVLAWEHERFAIRRLPAFTLSHLESHRAGPRSSIMDVRSRVDSKTLTRNTRIIAEALTRVIYNLTEKGTPPDMPVFTEQMQVQEEQIDSVMDWLTNQPRAAQLLDKDGTFLSTLEHFLSRYLKDVRQHHVKADKRDPEFVFYDQLKQVMNAYRVKPAIFDLLLALCIGAYLGMAYTAVQHFHVLYKTVQRLLLKAKAQ
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes.  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity).  May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity).
What are the official names of this protein?
BOS complex subunit NCLN, Nicalin, Nicastrin-like protein.
What is the protein family that this protein belongs to?
Belongs to the nicastrin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: SYFB_MOOTA
Sequence: MRVPYKWLQQYVDVTLPPAELADKLTMAGLAVEGVEDLTPGFQKVVAGKIKTITPHPDADHLVICNVDAGRELQLVTGAPNVHEGQMVAVALEGARLPGGREIHRATFRGVVSEGMLCSAQELGLDVSLVSPEDREGIITLPPDASPGADAAEVLGLKDVVLVLELTPNRADCLSILGVAREVAAITGAPIHLPATLPGEDGPEITGLATVEITAPDLCARYVARLVQGVRIGPSPAWLQAFLRAAGMRPINNVVDITNFIMLEMGQPLHAFDYDLLEGHRIIVRRAGPGEKITTLDGVERELDPEMLVIADAARPVAVAGVMGGLATEVTPATTNILIESAHFDGASIRRTSRRLGLRSEASTRFERGVNLEGAPAAADRAARLMAELAGGRVAPGRIDCYVKRRQPVTIELRPERVNYLLGTELAPTTMKELLERLHLEVRGEGPFQVTVPAYRGDLTGEIDLVEEIARLYGYNRIPVTLPGNLTAREKQAPAQRWEEAGREAAAAAGLAEVITYSFIGPRALDQLRLPEDHPWRRTVKIQNPLREEQSIMRPSLLPGLLEVAGRNASRRVLPVAIYELGRVFIPAGSRRPGEPLRLAGLVMGTTPRGWNWPAGEMDFYYLKGILESIFSRLRVRDVSWEASNAYPFLHPGRAATIKAGTRVLGYLGELHPDVLAAVELPARACAFELDWEAAGDLALRVPRYEPLPRFPAVERDLAVVVPATTPAAAVAGVIREAGGELLRAIALFDVYEGAPVPEGCKSLAYSLVYQLPDRTLTDAEVNAAQERIQRALEERLGASLRQ
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FCRL6_HUMAN
Sequence: MLLWTAVLLFVPCVGKTVWLYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIAAALLVYVRSWRKAGPLPSQIPPTAPGGEQCPLYANVHHQKGKDEGVVYSVVHRTSKRSEARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVNMRSRTLQEPLSDCEEVLC
What is the function of this protein?
Acts as a MHC class II receptor (PubMed:20519654).  When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291).  Does not act as an Fc receptor (PubMed:18991291).
What are the official names of this protein?
Fc receptor-like protein 6, FcR-like protein 6, FcRL6, Fc receptor homolog 6, FcRH6, IFGP6.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: Y514_ENCCU
Sequence: MSIMKSKIAKTLVVVVVAIAIFTLVLLMLWEGPLGTLTEENLTELNGEVPFRFKDSGSNEEGKDVTLSKFFVCLNKVLRSADDSLSSYLCCGETSEEEGESKKGKYVKNAITEARNMMFRVKDSKDVILEILKKGDKNRNELAETVSNAFSAVETSEGSDQESEGADEQGKIEKLNTALAELYIWIWLKGIPEEDKRTLQFRKTYKENQSVKNLLDGLDEENREVAESTILVKVGKKEDSMHVIEHILTSIFQANGYMEKGSIKQAYLSAKASVAAAGGSLGKKVSEVSDNEGKGLIDSLFGMIGWRNNSNNNSSVSKKKEEQGVNS
What are the official names of this protein?
Uncharacterized membrane protein ECU05_0140.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL6_RIPO1
Sequence: MSRIGKRPIPIPNKVTIDIQGQHVAVKGPKGSLERTLPDKVNVVQENDTLLVQREDDSRTARERHGLTRTLVANMVEGVSKGFEKRLSIQGVGYRAQVQGTKLTLNVGYSKPVEMTMPAGIQVAVENNTLVIVSGIDKEIVGNVSAEIRAVRPPEVYKGKGIRYSDEFVRRKAGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: IF2_THEPX
Sequence: MSKTRVYELAKELNLSSKDLISKLNDLDIKVKNHMSTLEDEEVELIMDLLRDKPQQTEEVHQKEEEDIFEDNLEDIEEERVYKKSFKKGSKKNKKNNKKAVLTEEKEEDEIKIITIPEFLTVKELAEKMKVNPTEIIKKLIAKGIMVTVNQQIDFENAAKIAEEYGFLVDKEEVKDELEMLLEETPDDEKDLQPRPPIVTVMGHVDHGKTSLLDAIRNTNVTMKEMGGITQHIGASVVEINDKKIVFLDTPGHEAFTAMRARGASITDIVVLVVAADDGVMPQTVEAINHVKAANVPMIVAINKIDLPTANPDRVKTELSELGLVPEEWGGNTICVPVSAKKNIGIDNLLEMILLVAEMEDLKANPNKPARGTIIEAKLEKGKGPVATVIVQNGTLQIGDAILAGTVYGKVRAMLDDKGRRIKKAGPSMPVEVLGFSEVPEAGDKLIVVEDEKKARELAERRKELQKEMELKRKQKVSLEDLFSQIQEGSVKELNIIIKADVQGSVEALKKSIEDLSNEEVRIKVIHGAVGAITETDVMLASASNAIIIGFNVRPETNAKNLAEKEKVDIKLYRIIYEAIEDIKAAMKGLLEPKYKEVELGRAEVRAVFRVPGVGNVAGCYVLSGKILRNSDIRVVRDGIVVYEGKIASLKRFKDDVREVQQGFECGIGIDRFNDIKEGDIIEAYQMEEIPR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.