PharMolix/UniProtQA huggingface dataset:
Protein: EPN4_MOUSE
Sequence: MLIFMYLYVCVCTCTCAFSLCSTNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYNERYDPEPKSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKARRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASPDQNASTHTPQSSAKPSVPSSKSSGDLVDLFDGSSQSAGGSADLFGGFADFGSAAASGNFPSQATSGNGDFGDWSAFNQAPSGPVASGGELFGSAPQSAVELISASQPALGPPPAASNSADLFDLMGSSQATMTSSQSMNFSLMSTNTVGLGLPMSRSQNTDMVQKSASKTLPSTWSDPSVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPLNVMTQSFGAVNLSSPSNMLPVRPQTNPLLGGPMPMNMPGVMTGTMGMAPLGNSAGMSQGMVGMNMNMGMSASGMGLSGTMGMGMPSMAMPSGTVQPKQDAFANFANFSK
What is the function of this protein?
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).  May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes.  Stimulates clathrin assembly (By similarity).
What are the official names of this protein?
Clathrin interactor 1, Enthoprotin, Epsin-4, Epsin-related protein, EpsinR.
What is the protein family that this protein belongs to?
Belongs to the epsin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans- Golgi network (By similarity).
Protein: PTSN_HAEIN
Sequence: MKITELLSPENIRQGVSFSSKKRLFESIAHFVEEQILAEKGEQACFECLFEREKLGNSGLGNGIAMPKAKIPVTVSDKAIAVFMQLDNPIDYDAFDGKPVDLIFALLIPENQCETYIPVLASLIEKLTDKNVLKQLRSAKSADEIWQVFEITDQSETTFEEVKE
What is the function of this protein?
Not known; lacks the phosphorylation site found in other PtsN proteins.
What are the official names of this protein?
Nitrogen regulatory protein homolog.
Protein: NU5C_BRAPI
Sequence: HFQNYSSTKEGSLYSISLWGNRIPKGVNKDFVLSTTKSEVSFFSQNISISKGQGNTRNRTGSFSTSFGSKNVFTYPHETGNTMLFPLLILLLFTFFIGFIGIPFDNRTMDNGIVRLTILSKWLIPSINFTQESSNFSINSYEFITNAISSVSLAILGLFIAYIFYGSAYSFFQNLDLQNSFYKGSPKKNFFYQVKKKIYSWSYNRGYIDIFYSX
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: HUTI_YERE8
Sequence: MVSTIHCDSLWYGADIVTMRGGKYHLIPQGAMAVTDGKIVWIGPYNELPRLSASREVIYSSGLITPGLIDCHTHLVFGGDRSAEFEQRLNGVSYAEIAANGGGIVSTVRATRNASEQQLLEQALFRLKPLLAEGVTCIEIKSGYGLSLESEIKMLRVARQLGELLPVTVKTTCLAAHALPPEFSGRADDYIDFVCDTIIPQVAKEKLADAVDAFCEHLAFSLAQVERVFLAAQQAGLPVKLHAEQLSSLHGSTLAAKFNAMSADHLEYATESDVRAMADAGTVAVLLPGAYYLLRETQCPPIELFRQYNVPMALASDANPGTSPALSLRLMLNMACTLFRMTPEEALAGVTCHAAQALGLQETQGTLETGKLANWVHWPLSHPAELAYWLGGQLPASVVFQGDARP
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PI4KB_HUMAN
Sequence: MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
What is the function of this protein?
(Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.
What are the official names of this protein?
Phosphatidylinositol 4-kinase beta, PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta, NPIK, PI4K92, PI4KIII.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
Protein: UNC62_CAEBR
Sequence: MSADSKVWAHASADTWTTAQGISTYDLDTSSIKREKIDCHEQFNDGYGPPPGTASTDAVSYAADPTAYFNLYTNMGAAPTTTPMMHHEMGEAMKRDKEAIYAHPLYPLLVVLFEKCELATSTPRETSRDGTTSSDVCSSASFKDDLNEFVKHTQENADKQYYQPNPQLDQIMLQSIQMLRFHLLELEKVHELCDNFCNRYVTCLKGKMPLDIVGDERASSSQPPMSPGSMGHHGHSGSPSMGGAGAATPMHYPPPYEPQSVPLPENVLGGGHPLEMFPGSSMAYAMAGMAAAAASSSSSQPQPGDHPLANGGTLHSTAGASQTLLPIAVSSPSTCSSGGLRQDSTPLSGETPMANGNSMDSISEAERIRRRFYMCVIVSAGPSSSSLHQHHLHHPHHFPHHQLQPPAHHQDFLLPPPPQNIIEQSLHCAGVSMLDASLIPPSSSSSASEYHGDMMSHMYSHHDVYHHQDMTYTDYGDYGTPDVVMMSSSDVKMEDAASVSSSKSGGKKQQPGTPNGRVGKSRGRDEFSVCGSNEDGRDSVLSDSANGSQNGKRKVPKVFSKEAITKFRAWLFQNLAHPYPSEEQKKQLAKETGLTILQVNNWFINARRRIVQPMIDQNNRAGRTPHMNVCKNRRRNRSEQSPGPSPDSESDSGANYSPDPTSLAAATAMHYPGAELYMQRTMNYGGFQPFPNPAMQFMNPMMGFPVAPAVDAISQQWIDLSAPHE
What is the function of this protein?
Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis.  Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis.  Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage.  Required for multiple roles in regulating vulva development (By similarity).
What are the official names of this protein?
Homeobox protein unc-62, Uncoordinated protein 62.
What is the protein family that this protein belongs to?
Belongs to the TALE/MEIS homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CB042_MOUSE
Sequence: MEPNSQRTKVPAFLSDLGKATLRGIRKCPRCGTFNGTRGLSCKNKTCGTIFRYGARKQPSIEAVKIITGSDLQVYSVRQRDRGPDYRCFVELGVSETAIQTVDGTIITQLSSGRCYVPSCLKAATQGIVENQCQHIKLAVTCQAEATPLTLKSSVLNALQAAPETKQSLWQLATEPTGPLVQRVTKNIMVVKCKASQKHNLGYLHASFMQKISSRSLPERRFFCSCQTLRPHKSSVPKAEAAPKCIHFFACLCAFASDETLAQEFSDFLNFDASGLKEIIVPHLGCHAESSVSACESAASKPRKRKKDEVSGAQVNSSLMPQDAVNSNLRKSGLKRPVVTSSLKRHVCGQLLDEAQVTLSFQDWLASVTERIHQTMHYQFDGKPEPLVFHIPQSFFDALQQRISIGSAKKRLPNSTTAFVRKDALPLGTFSKYTWHITNILQVKQILDTPEMPLEITRSFIQNRDGTYELFKCPKVEVENIAESYGRIEKQPVLRPLELKTFLKVGNTSPDQKEPTPFIIEWIPDILPQSKIGELRIKFEYGHHRNGHVADYQDPRPPMDQPLELAPLTTITFP
What are the official names of this protein?
Uncharacterized protein C2orf42 homolog.
Protein: RL18A_SULAC
Sequence: MAEVKIFMVRGTAIFSASRFPTSQKFTKYVRALNEKQAIEYIYSQLGGKNKIKRYNIHIQEIKEVKEDEITDKTIRDLAKLDKIIM
What are the official names of this protein?
50S ribosomal protein L18Ae, 50S ribosomal protein L20e, 50S ribosomal protein LX.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL20 family.
Protein: HEM3_GEOSW
Sequence: MRKIIVGSRRSKLALTQTNWVIERLRQLGAPFEFEVKEIVTKGDKIIDVTLSKVGGKGLFVKEIEHAMLNGEIDMAVHSMKDMPAVLPDGLIIGCVPPREDHHDVLISKNKETFANLPSGAIVGTSSLRRSAQILAKRPDLKIKWIRGNIDTRLAKLQNEDYDAIILAAAGLVRMGWARDVITEYLSTDVCLPAVGQGALAVECRENDEELREWLQKLNDVHTERAVLAERVFLQQMEGGCQVPIAGYAYIDDREDIVLTALVASPDGKEIYKETVSGSNPEEVGTNAAKMLIERGAKALIDRIKEEMNRQ
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RB39B_MOUSE
Sequence: MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDFFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLDTQRQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSGFVPNVVHSSEEVIKSERRCLC
What is the function of this protein?
Small GTPases Rab involved in autophagy.  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity).  May be involved in vesicular trafficking (PubMed:20159109).  Plays a role in synapse formation.  May regulate the homeostasis of SNCA/alpha-synuclein (PubMed:25434005).  Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (PubMed:25784538).
What are the official names of this protein?
Ras-related protein Rab-39B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Note=Partial colocalization with markers that cycle from the cell surface to the trans-Golgi network.
Protein: RL34_THET8
Sequence: MKRTWQPNRRKRAKTHGFRARMRTPGGRKVLKRRRQKGRWRLTPAVRKR
What is the function of this protein?
Found on the solvent side of the large subunit.
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: PYRE_CAUSK
Sequence: MTNDDVLDEFRAAGALREGHFVLSSGLHSPIFLQKNLVFMRPQRCERLCKALAEKIIATVGQPDVAVSPAVGGIIPGYETARWLNVASIYVEREGGSFKFRRGFHLEPGQKVVMVEDIVTTGLSSRECIAAIQEAGGEVIAAACIVDRSGGKVDVGVPLVSLCSLEVPAYPADALPPELAAIPIEDPGSRRLRG
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: CCDP_MAIZE
Sequence: MAPKVALFLALSLLFAATAHGCEPNCSGPVVPTPPVVPTPSSHSHGRCPIDALKLKVCAKVLGLVKVGLPQYEQCCPLLEGLVDLDAALCLCTAIKANVLGIHLNVPLSLNFILNNCGRICPEDFTCPN
What is the function of this protein?
Delineates a novel subset of developing cortical cells.  It is probably involved in some aspect of transport of molecules to or from the vasculature.
What are the official names of this protein?
Cortical cell-delineating protein, Root-specific protein ZRP3.
What is the protein family that this protein belongs to?
To carrot DC2.15 and PEMB3.
Protein: Y009_CHLTE
Sequence: MHTPLEQQEIRYRKGDIIELTITDHAEKDKCFGKTTEGMGVMVSGILAPGDRVSAQIYKVKSRYLEARAIEVLEASPDRVEPVCPVFGSCGGCKWMHVSYEAQLRYKHKKVTDSLEHIGGFESPDVRPVLAAPDALHYRNKVEFSCSNMRYLLQSEIDSDQLAKPKTFALGFHAPGNFEKVLDLDTCYLAKECMNRVLNVLRDFAIERGLEPYAAKAHEGYLRNLMLRYSERHEQLMVNIVTSWYDKALMQALKERLEAAMPEQQMTLLNNVTTRKNTVATGEQEYVISGDGYVTERLGDLDFRISANSFFQTNTRQAETLYDQIIAVGGITPEDTVYDLYCGTGTITLYLARHCKQAIGIEVVESAVKDAEMNAELNGLSNTVFFQADLKNFHAMQEALEPYAKPRIIVTDPPRAGMHPKALDTMLKLQPERIVYVSCNPDNLARDGKEIAARGYRMTSAQPVDMFPQTNHIETVACFERAE
What are the official names of this protein?
Uncharacterized RNA methyltransferase CT0009.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: NFS1_MOUSE
Sequence: MVGSVAGNMLLRAAWRRASLAATSLALGRSSVPTRGLRLRVVDHGPHSPVHSEAEAVLRPLYMDVQATTPLDPRVLDAMLPYLVNYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLVTTQTEHKCVLDSCRSLEAEGFRVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEIGQICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSISGHKLYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVGLGAACELAQQEMEYDHKRISKLAERLVQNIMKNLPDVVMNGDPKQHYPGCINLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVDYTAEKCIHHVKRLREMSPLWEMVQDGIDLKSIKWTQH
What is the function of this protein?
Mitochondrial cysteine desulfurase, of the core iron-sulfur cluster (ISC) assembly complex, that catalyzes the desulfuration of L-cysteine to L-alanine, as component of the cysteine desulfurase complex, leading to the formation of a cysteine persulfide intermediate at the active site cysteine residue and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:25597503).  The persulfide is then transferred on the flexible Cys loop from the catalytic site of NFS1 to the surface of NFS1 (By similarity).  After the NFS1-linked persulfide sulfur is transferred to one of the conserved Cys residues of the scaffold, a reaction assisted by FXN (PubMed:25597503).  The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis.  This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner.  Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly.  Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).
What are the official names of this protein?
Cysteine desulfurase, m-Nfs1.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm. Nucleus.
Protein: ZN524_MOUSE
Sequence: MDNPSSDPLPSTLSGEEEKPLALLPPVPRGRRGRPPGGATTSNRTLKSSLPRKRGRPPRSEQETPLTAPVDSGGSSDLLLIDDQGVPYTVPEGSAADGPQGSGSKRAPHFCPVCLRAFPYLSDLERHSISHSELKPHVCKDCGKTFKRSSHLRRHCNIHAGLRPFRCVLCPRRFREAGELAHHHRIHSGERPYQCPSCRVRFTEANTLRRHYKRKHPELVGMPVRLCPPNPRTQPLWDDDEGIPVQEGVQEESPEGKEPTWPISSTTSPLSGFTAGGSAGAGRGQEGQDTLVSGGIPTMEGDQKQGPKPLGPGAIGHPPVD
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 524.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIP2_ORYSJ
Sequence: MATTNCLLALAIAGLVLVSLPGLSRGDVDARRGRELAGGCNPSGTLRPSRSHSCQDCCKAGRSYPTYACSPATTGSTKAVMTLNDFEAGGDGGDPSECDGKFHKNTERVVALSTGWYANGRRCNKNIRINANGRSVLAKVVDECDSLHGCDKEHAYQPPCRPNVVDASQAVWDALRITGEDVGEYDITWSDA
What are the official names of this protein?
Putative ripening-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the kiwellin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZAPC_PSYIN
Sequence: MCKKTHRIIDFRPQANWYWLFDHNRAILTLNMGDRVIDIVYKPEMLILKFDQPVFFTIEDVANYMDLFEGPALGDYWPALRSQIILHALVANQFHKPIMPKNWLFESSVGEQPRVHKGDHIILKSSAIKEAKKYFVLDNDENFILCMLIEKSHGLTFNRNFVQFQIVKVTYDKIFATKADCNTLSQYV
What is the function of this protein?
Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ.  Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
What are the official names of this protein?
Cell division protein ZapC.
What is the protein family that this protein belongs to?
Belongs to the ZapC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK2_CRUWA
Sequence: MAIHLYKTSTPSTRNGAVASQVKSNPRNNLIYGQHHCGKGRNARGIITARHRGGGHKRLYRKIDFRRNAKDIYGRIVTIEYDPNRNAYICLIHYGDGEKRYILHPRGAIIGDTIVSGTEVPIKMGNALPLTDMPLGTAIHNIEITLGKGGQLARAAGAVAKLIAKEGKSATLKLPSGEVRLISKNCSATVGQVGNVGVNQKSLGRAGSKCWLGKRPVVRGVVMNPVDHPHGGGEGRAPIGRKKPVTPWGYPALGRRTRKRKKYSETLILRRRSK
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL3R1_MOUSE
Sequence: MQVASATPAATVRKAAAGDELSEFFALTPDLLEVANASGNASLQLQDLWWELGLELPDGAAPGHPPGGGGAESTDTEARVRILISAVYWVVCALGLAGNLLVLYLMKSKQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVARYHSVASALKSHRTRGRGRGDCCGQSLRESCCFSAKVLCGLIWASAALASLPNAIFSTTIRVLGEELCLMHFPDKLLGWDRQFWLGLYHLQKVLLGFLLPLSIISLCYLLLVRFISDRRVVGTTDAVGAAAAPGGGLSTASARRRSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFQCQVYAFPVSVCLAHSNSCLNPILYCLVRREFRKALKNLLWRIASPSLTNMRPFTATTKPEPEDHGLQALAPLNAAAEPDLIYYPPGVVVYSGGRYDLLPSSSAY
What is the function of this protein?
Receptor for RNL3/relaxin-3.  Binding of the ligand inhibit cAMP accumulation (By similarity).
What are the official names of this protein?
Relaxin-3 receptor 1, RLN3 receptor 1, G protein-coupled receptor SALPR homolog, Relaxin family peptide receptor 3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HOG1_MAGO7
Sequence: MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSARDQLTNQNVAIKKIMKPFSTPVLAKRTYRELKLLKHLKHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPKRERQPLKNKFKNADPSAIDLLERMLVFDPKKRITATEALAHEYLTPYHDPTDEPIAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNAEAGMQQMDDQFTGQ
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase HOG1, MAP kinase HOG1, Osmotic stress MAP kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ABI1_RAT
Sequence: MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKHGNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPAAPGAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD
What is the function of this protein?
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2.  May play a role in regulation of EGF-induced Erk pathway activation.  Involved in cytoskeletal reorganization and EGFR signaling.  Together with EPS8 participates in transduction of signals from Ras to Rac.  In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex.  Regulates ABL1/c-Abl-mediated phosphorylation of ENAH.  Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.  In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
What are the official names of this protein?
Abl interactor 1, Abelson interactor 1, Abi-1, Eps8 SH3 domain-binding protein, Eps8-binding protein, e3B1.
What is the protein family that this protein belongs to?
Belongs to the ABI family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Postsynaptic density. Cytoplasm, cytoskeleton. Note=Localized to protruding lamellipodia and filopodia tips. May shuttle from the postsynaptic densities to the nucleus.
Protein: RUVC_MYCS2
Sequence: MRVMGVDPGLTRCGLSMIESGKGRQVIALDVDVVRTPADTPLQKRLLTISDAAEHWMDTHRPDVIAIERVFANQNANTAMGTAQAGGVIALAAAKRDIEVHFHTPSEVKAAVTGSGRADKSQVTEMVTRILALQAKPTPADAADALALAICHCWRAPMIARMAAAEAMAEEQRRKFQAKIKAARG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: ARNE_SHIB3
Sequence: MIWLTLVFASLLSVAGQLCQKQATCFVAINKRRKHIVLWLGLALACLGLAMVLWLLVLQNVPVGIAYPMLSLNFVWVTLAAVKLWHEPVSPRHWCGVAFIIGGIVILGSTV
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE, L-Ara4N-phosphoundecaprenol flippase subunit ArnE, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE.
What is the protein family that this protein belongs to?
Belongs to the ArnE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ERPA_ERWT9
Sequence: MTDDVALPLQFTDAAASKVKNLISDENNPDLKLRVYITGGGCSGFQYGFTFDDKVNEGDMTIEKSGVALVVDPMSLQYLVGGSVDYTEGLEGSRFIVTNPNAKTTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: GLPK_STRU0
Sequence: MSEEKYIMAIDQGTTSSRAIIFNKKGEKIASSQKEFPQIFPQAGWVEHNANQIWNSVQSVIAGAFIESSIKPGQIEAIGITNQRETTVIWDKKTGLPIYNAIVWQSRQTAPIADQLKEDGYTDLIHEKTGLVIDAYFSATKIRWILDHVPGAQERAEKGELLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDEEILKLLNIPKAILPEVKSNSEVYGKTAAFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGEDMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMIETSPESEALALASTSDDEIYVVPAFTGLGAPYWNSNARGSVFGLTRGTTKEDFVKATLQSIAYQVRDVIDTMQIDSGIDIQQLRVDGGAAMNNLLMQFQADILGIDIARAKNLETTALGAAFLAGLAVGYWEDLDSLKELNETGQLFKASMNESRKEKLYKGWKKAVMATQIFAEE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.