PharMolix/UniProtQA huggingface dataset:
Protein: BAP29_HUMAN
Sequence: MTLQWAAVATFLYAEIGLILIFCLPFIPPQRWQKIFSFNVWGKIATFWNKAFLTIIILLIVLFLDAVREVRKYSSVHTIEKSSTSRPDAYEHTQMKLFRSQRNLYISGFSLFFWLVLRRLVTLITQLAKELSNKGVLKTQAENTNKAAKKFMEENEKLKRILKSHGKDEECVLEAENKKLVEDQEKLKTELRKTSDALSKAQNDVMEMKMQSERLSKEYDQLLKEHSELQDRLERGNKKRL
What is the function of this protein?
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.  May be involved in CASP8-mediated apoptosis (By similarity).
What are the official names of this protein?
B-cell receptor-associated protein 29, BCR-associated protein 29, Bap29.
What is the protein family that this protein belongs to?
Belongs to the BCAP29/BCAP31 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MTNN_SHEHH
Sequence: MKIGIIGAMEPEVAHLVESMENPSSTTIAGIEFVAGQLAGKDVIVTRSGIGKVTASIATTLLIEKYAPDVIINTGSAGGFADELAIGDIVISSEVRHHDVDVTAFGYEIGQMAQQPAAFIPDAKLVAAAQKAVASLGEVKAIEGLICTGDSFICDPVRTKTMLENFPTMAACEMEGAAIAQVCHQFGVPFVVIRSLSDNANNDSPVDFDEYIVKAGHHSALMVIALLKQL
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: ICK26_TRILK
Sequence: MKTIIVFLSLLVLATKFGDAKEGVNQKQKKEVTQNEFREEYLNEMAAMSLVQQLEAIERALFENEAGRNSRQKRCNGENVPCGPNHSTCCSGLSCEETFGYGWWYASPYCVKPSKG
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U16-barytoxin-Tl1b, U16-BATX-Tl1b, Toxin ICK-26.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 14 (magi-1) family. 06 (ICK-Trit) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HEMTB_RALSO
Sequence: MPVIQWSEALHLGDAATDANHAAFCTLLNAVADASEADFVSALDAFIAHTEVHFAEENAWMEAADFPPLHCHRNEHDNVLALCREVRRRAADGDMALGRRLVTELPEWFAQHVDVMDRMMTTWLAQRGPDAREEAAA
What is the function of this protein?
Oxygen-binding protein.  May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes.  The oxygen-binding site contains two iron atoms.
What are the official names of this protein?
Bacteriohemerythrin.
What is the protein family that this protein belongs to?
Belongs to the hemerythrin family.
Protein: TXA1_ACAGO
Sequence: IIECFFSCEIEKDGKSKEGKPCKPKGDKDKDKKCSGGWRCKIKMCLKI
What is the function of this protein?
Is toxic to both insects and mammals.  Induces reversible paralysis when injected into S. frugiperda larvae.  Reduces both the amplitude and frequency of responses from muscle (GF-TTM and GF-DLM) pathways in the D. melanogaster giant fiber circuit, suggesting an action at the neuromuscular junction, which is mediated by glutamatergic receptors.  In mice, intracranial injection of 30 ug causes increased urination, myoclonus, hypermotility with circular movements followed by respiratory and generalized seizures resulting in death within 25-35 minutes of injection.
What are the official names of this protein?
U1-theraphotoxin-Agm1a, U1-TRTX-Agm1a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 12 (Hwtx-2) family. 01 (Ap1a) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NU6M_FELCA
Sequence: MMTYIVFILSTVFVVSFVSFSSKPSPIYGGFGLIVAGGTGCGIVLNFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEPYPEAWTSNKAVLAMFITGVLAELLTACYILKEDEVEVVFKFNGAGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVVVTGWSLLIGVLVIMEVTRGN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TVP18_LODEL
Sequence: MALGETITQNVFGGLSNDFKKKNFSLYGQWISIFTIFLCIALGIANIFHFNLVIIFSVICIVQGLIVIFVEVPFLLRICPLTDTFTNFIRKFDGNLPRCGFYLLNAVIQWLSCTLQATSLIVVAIFFTLASACYALAYAKNQEYLKSSIDVTGTGQGGALEAQVGEHVVRNVL
What is the function of this protein?
Golgi membrane protein involved in vesicular trafficking.
What are the official names of this protein?
Golgi apparatus membrane protein TVP18.
What is the protein family that this protein belongs to?
Belongs to the TVP18 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: IR221_CANAW
Sequence: MKLSTIFTAFAATIATVAGYETTGSKQTVDILIDYIIKETPELSQNDVANWENGDTVTLQYVVNNNEESEITVVGVTGQFKNPVNNEIVTNLTTGKVGPIAVPPGEAIKFDQKINVDLIPANYELIPYVFIAQDSLIKVIPCRGQLATIVDAAVSFFDPRLIFLELVLLITFAGLIYVGYEIWGKQYFKGVASVKAKKVSAAKASSPVASGPSTTSATGYDTNWIPESHLKQKKTKKVN
What is the function of this protein?
Is probably involved in a pathway contributing to genomic integrity.
What are the official names of this protein?
Increased recombination centers protein 22-1.
What is the protein family that this protein belongs to?
Belongs to the IRC22 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: FPG_CUPTR
Sequence: MPELPEVEVTRRGLLPHVVGRRIAAVTVRHRGLRWPVDPGLEACLAHRLVRRIERRGKYLLLECISADAAQPPGWLLVHLGMTGTLRVLPEAPPPGMHDHFDLLLDAGPAPGMLADTIVLRFRDPRRFGAILWTTLPEAELASHPLLSTLGIEPFDPAFDGAWLHRHTRGRSAAIKTVLLSGAIVVGVGNIYASESLFRAGIRPTTAAGRLSRARCDRLAQAVRDTLAQAIERGGSTLRDFVGSDGASGYFQLDCFVYDRAGLPCRVCATPVRQIVQGQRSTFYCPKCQH
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: EGG6_CAEEL
Sequence: MRWLTLIAVAHLIAFLSSAEITCPRIPEKCDCKISKSMIILSCNGEDVKTIAQTVGTSQIDELHILNGTDVKIESLPFNGLRTIAILNSTLQSFSPTAWRHVEATIEHITINGNELKTVPVFGNLSTLMSMNLNSNQISSIPDKAFNGLSALTQLRLENNAICDFPPKSLDAVKASLVLLDVSGNCLDAIPAQILRNAANLMYLDLGSNNISEINNFELMNLPFLRELRVQNNTLRRIHPMAFMNVPQLQYLYLQDNIISTLDGNRLQGFKNLEVLDVSNNALYALPSLKDLPNLKQVRVDGNLITKIETLAFSNNPNLQLISVQNNNIVQISRNSFESLDKLVVLLVGNNSLAKIERGMFDGMKNLQQLSIRNNTLTALDASSFAQLAHLTTLDLGHNKIHDIEEGTFDKLSKLFWLDLSNNKISGFKTSVFKKKISNILLDGNQLICDESFNEFLTYLIANKVRTFLPFQQEIMCHGPEKYAGVRLKDLMMKKANETLSEGSRLLGVPQGSNQHSLLSSFLPSLGPLGTLNGAGGAAIPLVNTLTNTIPALRSIPGFGGNIPVGTGASSVPNKNLNDAIEGFTGPLVRFATGGQPVASDIEQLIRSIPNMVVNVPGFGDIDLSKMDPTMIQYVLNGGQIPGIDKATLDKIVKQTMNKMHTAAAANLAGNPVEGQEKVLPPLDKLPSGLVTQVMSGEPLPGLNENQTKIIMEYYTHQMPGMDGIPARPVESQGNTTANNMFNPAMFDLLKMLPPGYNLSKIPMEVIAAVTRGEVPDMRLLPEDLLEHFKQHTTSLTSMFAGATAKNISIEEILEKLPVFVRPELSTFVPYDINELTSEMVLEQEQNERHRNIRIITAIALAFVGAVTVVVIIFFVNYTKKQRRLRKSLVYRSSPSSSGSSGQNAANESGRSSAAPSPIRPPLMNIPKTPNNRTMESTFGQPQLCSTLLENPQAVSHRSRH
What is the function of this protein?
Required for apical extracellular matrix organization and epithelial junction maintenance.
What are the official names of this protein?
Leucine-rich repeat-containing protein egg-6.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein.
Protein: PDLP8_ARATH
Sequence: MRRLFLFSLLFLFFYSSSSSRSSSESHIFIYGGCSPEKYTPNTPFESNRDTFLSSVVTSSSDASFNSFAVGNDSSSSSSSSAVFGLYQCRDDLRSSDCSKCIQTSVDQITLICPYSYGASLQLEGCFLRYETNDFLGKPDTSLRYKKCSSKSVENDYDFFKRRDDVLSDLESTQLGYKVSRSGLVEGYAQCVGDLSPSDCTACLAESVGKLKNLCGSAVAAEVYLAQCYARYWGSGYYDFSSDPTNGDHVGKSIAIIVGVIAGFAILVVLLSLCRNSMH
What is the function of this protein?
Modulates cell-to-cell trafficking.
What are the official names of this protein?
Plasmodesmata-located protein 8, PD-located protein 8, Cysteine-rich repeat secretory protein 15.
What is the protein family that this protein belongs to?
Belongs to the cysteine-rich repeat secretory protein family. Plasmodesmata-located proteins (PDLD) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, plasmodesma. Note=Co-localizes with the Grapevine fanleaf virus (GFLV) 2B-MP at the base of tubules within modified plasmodesmata (PubMed:20886105).
Protein: ASHWN_MOUSE
Sequence: MAGDVGGRSCTDAELLLHPELLSQEFLLLTLEQKNIAVENEVRVNKDNLTDLYVQHAIPLPQRDLPKNRWGKMMEKKREHHEVKNDTKRSSAVDGLRKRPLIVFDGSSTSTSIKVKRTENGADDRLKPLAQIGSTSDAFWKSPNSSSRISPLVLFSNLPVNHKMEHNNNDTQQNHDLMNRKSPSGPVKSPPLSPVGTTPVKLKRAAPKEEAEATNHLKPPEVKRKIQHVTWP
What are the official names of this protein?
Ashwin.
What is the protein family that this protein belongs to?
Belongs to the ashwin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: S39AD_PONAB
Sequence: MPGCPCPGCGMAGPRLLFLTALALELLGRAGGSQPALRSRGTATACRLDNKESESWGALLSGERLDTWICSLLGSLMVGLSGVFPLLVIPLEMGTMLRSEAGAWHLKQLLSFALGGLLGNVFLHLLPEAWAYTCSASPGGEGQSLQQQQQLGLWVIAGILTFLALEKMFLDSKEEGTSQVSGYLNLLANTIDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAAKLQLSTALGGLLGAGFAICTQSPKGVEETAAWVLPFTSGGFLYIALVNVLPDLLEEEDPWRSLQQLLLLCAGIVVMVLFSLFVD
What is the function of this protein?
Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol.  May regulate beige adipocyte differentiation.
What are the official names of this protein?
Zinc transporter ZIP13, Solute carrier family 39 member 13, Zrt- and Irt-like protein 13, ZIP-13.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: RS3_METB6
Sequence: MAVERKFIAEGARKARVEKYLTKELKRAGFGGMDIARTPLGTQVTIFAEKPGIVIGKGGKLVHQLTQDLAQNYGVESPQIEVQQVQNPSFNAQIMAERLANALERGWYFRKAGSSIMRRVMDSGALGCEVVIAGKLTGARARTQKFTEGYIKHCGEPSNTIVEKGYAIAIKKLGVIGVQVKIVPADAKMPDHFAIIEQEKKLPAPKTTVTAVIETDNEEPALPDENIDEEV
What is the function of this protein?
Binds the lower part of the 30S subunit head.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: HDFR_YERPP
Sequence: MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGANLFTRHRNNIRLTPAGERLVPYAEMLLNTWRLAKKEVIHSLQHTELSIGATASLWEAYLTPWLQQLYEQQEELRLEARIALRNSLVKQLHERQLDLLITTEPPKMDELACLLLGHFSLRLYSSFSLDLPKEDDTPNEHKNASEVPYIKLEWGADFHQQENRLLDSEQAPILTTTSAHLTRQLLETTGGCAFLPEHWQKEYPQLVIHPDIPPIVRPLYAVWLQNSDQQALIRQLLKTPMNNATQSVTRE
What is the function of this protein?
Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
What are the official names of this protein?
HTH-type transcriptional regulator HdfR, H-NS-dependent flhDC regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: 3DHQ_NEUCR
Sequence: MASPRHILLINGPNLNLLGTREPQIYGSTTLHDIEQASQTLASSLGLRLTTFQSNHEGAIIDRIHQAAGFVPSPPSPSPSSAATTTEAGLGPGDKVSAIIINPGAYTHTSIGIRDALLGTGIPFVEVHVSNVHAREAFRHHSYLSDKAVAVICGLGPFGYSAALDFLGRHMKF
What is the function of this protein?
Is involved in the catabolism of quinate.  Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.
What are the official names of this protein?
Catabolic 3-dehydroquinase, cDHQase, 3-dehydroquinate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: ATPA_MANSM
Sequence: MQLNSTEISELIKKRIAQFDVVSEARNTGTIVSVSDGIIRIHGLSEVMQGEMIALPTGRFAMALNLERDSVGAVVMGPYTDLAEGMEVQCTGRILEVPVGRGLLGRVVNTLGQPIDGKGEIKNDGFSPVEVIAPGVIDRKSVDQPVQTGYKAVDSMVPIGRGQRELIIGDRQTGKTALAIDAIINQRDSGVKCIYVAVGQKASTIANVVRKLEENGALANTIVVAASASESAALQYLAPYAGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVNEEYVENFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESNLFNAGVRPAVNPGISVSRVGGAAQTKAVKKLAGGIRTALAQYRELAAFAQFASDLDDATRKQLSHGEKVTELLKQKQYAPLSVAEQAVILFAVEFGYLDDVELNKIADFETALLDYANRTNTEFMQELTKSGDYNDEIKNTLKGILDNFKANNTW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MCRI2_HUMAN
Sequence: MYTITKGPSKLVAQRRTGPTQQQVEGRLGELLKCRQPAPPTSQPPRAQPFAQPPGPWPLSSPGPRLVFNRVNGRRAPSTSPSFEGTQETYTVAHEENVRFVSEAWQQVQQQLDGGPAGEGGPRPVQYVERTPNPRLQNFVPIDLDEWWAQQFLARITSCS
What are the official names of this protein?
MAPK regulated corepressor interacting protein 2, Protein FAM195A.
What is the protein family that this protein belongs to?
Belongs to the MCRIP family.
What are the subcellular locations of this protein?
Cytoplasm, Stress granule. Nucleus.
Protein: COX1_PLAFA
Sequence: MVLNRYSLITNCNHKTLGLYYLWFSFLFGSYGFLLSVILRTELYSSSLRIIAQENVNLYNMIFTIHGIIMIFFNIMPGLFGGFGNYFLPILCGSPELAYPRINSISLLLQPIAFVLVILSTAAEFGGGTGWTLYPPLSTSLMSLSPVAVDVIIFGLLVSGVASIMSSLNFITTVMHLRAKGLTLGILSVSTWSLIITSGMLLLTLPVLTGGVLMLLSDLHFNTLFFDPTFAGDPILYQHLFWFFGHPEVYILILPAFGVISHVISTNYCRNLFGNQSMILAMGCIAVLGSLVWVHHMYTTGLEVDTRAYFTSTTILISIPTGTKVFNWICTYMSSNFGMIHSSSLLSLLFICTFTFGGTTGVILGNAAIDVALHDTYYVIAHFHFVLSIGAIIGLFTTVSAFQDNFFGKNLRENSIVILWSMLFFVGVILTFLPMHFLGFNVMPRRIPDYPDALNGWNMICSIGSTMTLFGLLIFK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MPC2_MOUSE
Sequence: MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWRYNQELKSKGIQ
What is the function of this protein?
Mediates the uptake of pyruvate into mitochondria.
What are the official names of this protein?
Mitochondrial pyruvate carrier 2, Brain protein 44.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
Protein: VPS11_CAEEL
Sequence: MTEFGWRRFNFFDRSVVFDKDDPKQKFMGLKDVAVDCWCSSGGSVYLGEAKGGVFQLTNQFSEYYWKAYQKSLASLHSADKYLFSIGEDDETVNTLLKIWDPERVEKNTPHVMRTIRMSPLNPTSSSPACSIAVHSSLQSVVVGYTDGTVLFYQGDVLHDKSLNSRWIKVRDSSVGEGSVTGLAIAVLPASKTVVFVITQKHVHSYVLENGRTVIAHKKHDANGATADCWTFDESTGQLIVASREMLFFYDADQCIDMDGGEVGRCLQLGRGHEKLQLVASGQYLALLTKHHSLIQKERDSEFMTMLSVYDIKGQYVGFSCSLPNLCRLFIAGSTMLVLSHDGLLSELIEKNLATKLDILVKKSMFDVAVLIAKNSRDGGDYLKGIHAKYGNYLYGKGDYENAIQQYKETIGMLEPSYVMKRYLDSSKIKELCIYLECLHDAKRDNEHQTKILMNAYAKQGEKKKLMEFVNKITDGTRVSRMRDVFEILLKWNYLAEASLLATKFQMHEDALNVIIHHMHKYTMGVTYISKMPIESVIEMTGKFGRDLLIHARDDLMHMLWEKIQENTDAKKNNFMRIFDIFMGDMDASRVFLSYIENQTNEHDEFIIPILECQMRLFKVNSDWSQERLEEDIYRFINKKNEDAALQMAQLFDCTPVIEHILMRCHKSKELMMYHQKKRDLEAIIRLCQSCSKEEKRRLWLDALSFIGKHATARDELIIIDLLKEIEASEQIHPLVVLELLAKNEHLTISSVRDYIIAWLRKQQIIIEEDRNTIKENNKAMGELDGTVESLKFNAQIMQVTKCSACDTPLQLPTVHFLCKHAYHVHCFESYNMDGSDKCPACQTTRDTTRDEEISYHKFQKELAEASNGMELIAMYLQRGLFDEKTKKTKKSEAKKDPFSTGRASTTTNPFDDDEVTTISRTMSTVSSNMATPSRQRSITRKDDDSTNPFFNSDSGTRLSTYDESKNPFGAPAPSTNPFD
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:26783301).  Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity).  The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity).  Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells (PubMed:24501423, PubMed:25273556).  The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity).  Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25273556).  Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (By similarity).  Possibly has a role in clearance of apoptotic cells during programmed cell death (PubMed:18425118, PubMed:18923146).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 11 homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS11 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ORR3_ORYSI
Sequence: MSTKTVPEPEPHVLAVDDSIVDRTVISRLLRSSKYRVTTVDSGKRALEVLSLDRNVHMIITDYCMPEMTGFDLLKRVKESAELKEIPVVLMSSENSPTRIRRCLEEGAEDFLIKPVRPSDVSRLCNRVIMK
What is the function of this protein?
Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system.  Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes.  Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
What are the official names of this protein?
Two-component response regulator ORR3, Type A response regulator 3, OsRR3.
What is the protein family that this protein belongs to?
Belongs to the ARR family. Type-A subfamily.
Protein: RSFB_MYCTO
Sequence: MSAPDSITVTVADHNGVAVLSIGGEIDLITAAALEEAIGEVVADNPTALVIDLSAVEFLGSVGLKILAATSEKIGQSVKFGVVARGSVTRRPIHLMGLDKTFRLFSTLHDALTGVRGGRIDR
What is the function of this protein?
Positive regulator of sigma-F (SigF) activity.  Binds to anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription (By similarity).
What are the official names of this protein?
Anti-sigma-F factor antagonist RsfB, Anti-anti-sigma F factor RsfB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor antagonist family.
Protein: MCR_PIG
Sequence: QYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTRCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPRCWWRSSPT
What is the function of this protein?
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol.  Binds to mineralocorticoid response elements (MRE) and transactivates target genes.  The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity).
What are the official names of this protein?
Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane (By similarity).
Protein: U83A1_ARATH
Sequence: MDNNSNKRMGRPHVVVIPYPAQGHVLPLISFSRYLAKQGIQITFINTEFNHNRIISSLPNSPHEDYVGDQINLVSIPDGLEDSPEERNIPGKLSESVLRFMPKKVEELIERMMAETSGGTIISCVVADQSLGWAIEVAAKFGIRRTAFCPAAAASMVLGFSIQKLIDDGLIDSDGTVRVNKTIQLSPGMPKMETDKFVWVCLKNKESQKNIFQLMLQNNNSIESTDWLLCNSVHELETAAFGLGPNIVPIGPIGWAHSLEEGSTSLGSFLPHDRDCLDWLDRQIPGSVIYVAFGSFGVMGNPQLEELAIGLELTKRPVLWVTGDQQPIKLGSDRVKVVRWAPQREVLSSGAIGCFVSHCGWNSTLEGAQNGIPFLCIPYFADQFINKAYICDVWKIGLGLERDARGVVPRLEVKKKIDEIMRDGGEYEERAMKVKEIVMKSVAKDGISCENLNKFVNWIKSQVN
What are the official names of this protein?
UDP-glycosyltransferase 83A1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: DIML_CAEEL
Sequence: MNLVDEKDEKPTRWEKCVEFIMFHFRWVFVVPFLLPLSFLFNTVFDFRNRIVHAVNSAPNAHVRKVKHIQEQLKEWNDNGRKSKLVNARPGWLTMSFRFPLYKENATKIATDKLFDILDLDVEKMTVKAEPGVTMGQLSQYLISRGYTLPVLPELDDLTVGGLINGCGVESGSFKYGMFQHICTGYEVVMSDGELKNVYPDSAAKTEQAKQDNSLFFAIPWSQGTICFLVAATIKIIPCKKYVKLTYKKTETLSEMCEQLTEDSDRNSENVDFVEALMFNKEKGCIMLGEFSDGPDTHDEVVNPIGRWYKKWFYTHVEDLINKKHESIEYIPLRDYYHRHSKSIFWELRDIVPFGNNVLFRYLMAWMCPPKIAFLKATTPNVLRKLYDRSHVLQDMLVPLDKLEECIDLFHKEVEIYPMWLCPFYLKSQPGLMKLRNATHKMYVDVGAYGVTSKDGYHHERTTRRLESFVRSVNGFQMTYADIYMTRAEYAEMFDRTLYDWKRASCKCIDAFPDIYDKICRSGRR
What are the official names of this protein?
Diminuto-like protein.
What is the protein family that this protein belongs to?
Belongs to the DIMINUTO family.
Protein: RNPA_NITOC
Sequence: MKQFGFTRLMRLVDPGDFKQIFAAGERVSSKAFTVLYHSNSLEYPRLGMAIPRKHFSRAVDRNRIKRLVRESFRQRQQVLGGRDLVVLSKPGINRHPNSDLLRCLERQWIGLVKQCSDS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: FB114_ARATH
Sequence: MSSSPEKKRRKKLSPESNSLPNDLIVTILARLSQSYYPKLSLVSKTFRAILASPELYQTRILLSRTETFLYVCLSFPGEPNPGWFTLYRKPNQTLTTKKKKNSVHLLAPILNSPPVEFPSLIAVGSYLYAFRAAIEEGTSDSLNCVEVYNTDTQTWIPVPPNKRIFKLQHMKGMLYMKVSKLLSFVAQDAEELAPLFPKLRSLLSTEVVAFKPKVSEGYEVLGFSVNTDLGRGSFCMIEEITYHYDPSVKFRWRRRQGGVWRSLVGLEGLPKFARYSSVKLADCGGKLVVLWHKYVPASGYEEKMVWCAEISLEKRSKKEIWGKIEWFDAVLRVPKYYQFVGAKSATV
What are the official names of this protein?
F-box protein At2g20380.