PharMolix/UniProtQA huggingface dataset:
Protein: CP4CA_MOUSE
Sequence: MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRSDPKANGSYRFLAPWIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANSACKLAHDHTDQVIKSRRIQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGTSITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:17112342).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:17112342).  Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids (PubMed:17112342).  May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:17112342).  Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure.  Further catalyzes successive omega-oxidations of 20-HETE to the corresponding dicarboxylic acid, and may contribute to the degradation of PUFA by chain shortening (PubMed:17112342).  Acts as an omega-hydroxylase and epoxidase toward (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoc acid (EPA).  Catalyzes stereoselective epoxidation of the last double bond of EPA, displaying a strong preference for the (R,S) stereoisomer (PubMed:17112342).  Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:17112342).
What are the official names of this protein?
Cytochrome P450 4A12A, CYPIVA12.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: ATPD_ECOSM
Sequence: MSEFITVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENGQNLIRVMAENGRLNALPDVLEQFIHLRAVSEATAEVDVISAAALSEQQLAKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ACP_GEMAT
Sequence: MADHASKIKDIIEKELGVEREKLTPEASFIEDLGADSLDIVELVMEFEKEFNIDIPDEDAEKLRTVGDAVAYLEAKVGG
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_ALKPO
Sequence: MNTGHITQVMGPVVDVKFKSGQLPEINNALKVVQVGADKNAVDVTVTLEVALHLGDDSVRTVAMGSTDGLVRGTEALDTGAPISVPVGEATLGRVFNVLGEAIDLGEPVAADVKRDPIHREAPKFEELSTTTEILETGIKVVDLLAPYIKGGKIGLFGGAGVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLYHEMTDSGVIKKTAMVFGQMNEPPGARMRVALSGLTMAEHFRDRDGQDVLLFVDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTKVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERKLSEMGIYPAVDPLASTSRALSPEIVGEEHYSVARQVQQTLQKYKELQDIIAILGMDELSEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETIKGFKEILDGKYDDLPEDAFRLVGRIEEVIEKGKQMA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ATPF_MYCPU
Sequence: MNFGANLLTNYNEELTEKFYRLFPSIPLMLATLAALVISIFFLTYFFYKPIRKNIKKRKQYIQDNIDAANKLKQQSLENLEESNKKLNEAREQASEIINSSKRDAELIVINYKMSAQKKSEEILKKAQLEIKRKEEEFLRTSREEIIDAATIIAKKILIKEIDSNYEKKIIDDISFDSEK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: TT21B_MOUSE
Sequence: MDSQGLKTLINYYCQERYYHHVLLVASEGMKKYSSDPVFRFYHAYGTLMEGKAQEALREFEAIKNKQDVSLCSLMALMYVHKMSPNPDREAILELDTKMKEQRKEAGRKALYHAGLFLWHIGRHDKAREYIDRMSKMPHDSNEGPILKAWLDITRGKEPYAKKALRYFEEGLQDGNDIFALLGKVLCLEIRQNYSGALETVSQIIVNFPSFLPAFEKKMKLQLALQDWDQTVETAQRLLLQDNHNVEALRMLALYYLCREGDVEKAATKLENLGNALDVMEPQNAQLFYKITLAFSRTCGRNQLILQKVQSFLEKAFSLTPQQAEIATELGYQMILQGKVKEAWKWYRTAMTLNESNISAVTGLIRCQLIEGQLQDADQQLEFFSEFQQSMGKSAELMYLHAVLATKKNNRQDEVINLLNDVVNTHFSHLEDLPLGIQYFEKLNPDFLLEVVTEYLNLCPIQPAGPGQPLSPVLRRCSSVLETIIRSVPGLPQAVFLMAKVKYLSGDTEAAYNNLQHCLEHSPSYAEAHLLMAQVYLSQDKVKLCSQSLELCLSYNFNVREYPLYHLIKAQSQKKMGEVAEAIKTLHMAMNLPGMRRSRASSKSKHRTEVDASHRLSIFLELVEVHRLNGEQHEAAKVLQDAIHEFSGTCEELRVTIANADLALAQGDTDRALSMLRNVTTEQPYFIEAKEKMADIYLKHRKEKMLYITCYREIAERMPSPRSFLLLGDAYMNIQEPEEAIVAYEQALNQNPKDGTLARKIGKALVKTHNYSKAITYYEAALKSGQQNCLCYDLAELLLRLKLYEKAEKVLQHSLAHEPVSELSALMVDGRSQVLLAKVYSKMERPSDAIAALQQARELQARILKRVQMEQPDAVPSQKHFAAEICAEIAKHSAAQRDYEKAITFYREALVHCETDSKIMLELAQLYLAQEDLDASLRHCALLLQRDQDNEPATMLMADLMFRKQDYEQAVYHLQQLLDRKPDNFMTLSRLIDLLRRCGKLEDVPRFFLMAEKHNSRTKLEPGFQYCKGLHFWYTGEPNDALRHFNKARKDSDWGQNALYNMIEICLNPDNETIGGEVFENLNGDLGTSPEKQESVQLAVRTAEKLLKELKPQTVQGRLQLRIMENCCLMATKQKSSVEQALNTFTEIAASEKDHIPALLGMATAYMILKQTPKARNQLKRIAKMPWNPIEAEDLEKSWLLLADIYIQSAKYDMAEELLKRCLCHNRSCCKAYEYMGYIMEKEQAYTDAAFNYEMAWKHSNQTNPAVGYKLAFNYLKAKRYVDAIDVCHQVLEAHPTYPKIRKDILDKARASLRP
What is the function of this protein?
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs).  Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs (By similarity).  Negatively modulates the SHH signal transduction (PubMed:18327258).
What are the official names of this protein?
Tetratricopeptide repeat protein 21B, TPR repeat protein 21B, Intraflagellar transport 139 homolog, Tetratricopeptide repeat-containing hedgehog modulator 1.
What is the protein family that this protein belongs to?
Belongs to the TTC21 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Note=In polarized epithelial inner medullary collecting ducts cells and in the nodes of mice at 8.0 dpc, colocalizes with alpha-tubulin in cilia. Expressed in a punctate manner throughout the axoneme from the cilia base to the tip.
Protein: SYL_BIFAA
Sequence: MSDTEKSAQAQPNESAEPSFRYNAKLAQGIEEKWQKIWDDEGTFWAANVNGDLKDGKGHNAEGRPSYFAMDMFPYPSGKGLHVGHPLGYLATDVVSRYHRMKGENVLHAMGYDAFGLPAEQYAVQTGQHPRITTEQNIANMRRQLHRMGLSFDNRRSFATIDPGYVRWTQWIFSRIYDAWYDEDATNPSGSRGCARPISTLVEQFESGKRAIPGFEGKAWADLSEAEQADVLNDFRLAYISKSPVNWCPGLGTVLANEEVTAEGKSERGNFPVFQRELRQWSMRITAYGHRLIEDLDTIDWPEKVKLMQRNWIGESHGASVHFDVETPNGVKDMEIYTTRPDTLFGTTFAVVSPEHHLLEDVPAEWPAETPEDWKGGYATPVEAVKAYRLAAEAKTAKDRVDEAGEKTGLFTGLYAINPITGAKLPLFTADYVLMDYGTGAIMAVPGGDQRDYDFAVKFGLPVIYTVKPLPESGDDLANYEGKAPFVSHDGIVINSSIDATKAKGDSLSLDGLRVDEAIDKVNAWLESAGVGKGTVSYRLRDWLFSRQRYWGEPFPIVYGEDGTPHLLPDEQLPINLPDVPDYSPKTFDPEDAESDPEAPLSRNEDWVKVELDLGDGKKTYYRDTNTMPNWAGSCWYYMRYLDPTDTKHMVEKDEFDYWMGPDHNKTAGKSGGVDLYIGGVEHAVLHLLYSRFWHKVLFDLGYVDSMEPFHKLFNQGMIQAYAYTDDRGQYVPAAEVVEGPADANGEPTFTWNGQHANREFGKMGKSLKNIITPDDMYENYGADTFRLYEMGMGPLAESRPWNTRNVVGSMRFLQRLWRNVIDETTGEVRVTDGELDTKTLKLLNNTIADVTVEMEAMRPNTAIAKLIVLNNHLTSLDAVPRAAVEPLILMLSPIAPHICEELWSKLGHTESLAHADWPKADERYVGQDSVTAVVQIKGKVRAKLEVSPDIDPKELEKMALEAVADRLGGKEPRKVIVKAPKIVSIVPAE
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR_YERPP
Sequence: MSKVLVLKSSILATSSQSNQLADFFVEQWQAAHAGDQITVRDLAAQPIPVLDGELVGALRPSGTALTPRQQEALALSDELIAELQANDVIVIAAPMYNFNIPTQLKNYFDMIARAGVTFRYTEKGPEGLVTGKRAIILTSRGGIHKDTPTDLVVPYLRLFLGFIGITDVEFVFAEGIAYGPEVATKAQADAKTLLAQVVAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: YDG2_ARATH
Sequence: MMMTQRISPSNKRRRVSFVRDFPQFSVKDESDIGGDDVATIKENLDGKEDSNCVGVAYRDHHRPKEESFDSIMKKAGFNVANGNLGNGKFPPSKRNVPLPCEGKVQPLSVEEGIKLMAYESQRRRCFGKPLVSTKVVQKHRYSPAKKKLSNATALRVRHSPMKKLSNASRLRANAHRPTQHKDERRSGVLSVIQRNRLSKDLTPRQKVQEVLRIFTLVFDELDRNKAARRGGSETAKSRIDYQTWTILREMGMQVNSQKRIGSVPGIKVGDKIQFKAALSVIGLHFGIMSGIDYMYKGNKEVATSIVSSEGNDYGDRFINDVMIYCGQGGNMRSKDHKAIKDQKLVGGNLALANSIKEKTPVRVIRGERRLDNRGKDYVYDGLYRVEKYWEERGPQGNILFKFKLRRTCQPYVDF
What are the official names of this protein?
YDG domain-containing protein At5g47160.
What are the subcellular locations of this protein?
Nucleus.
Protein: PANB_SHESR
Sequence: MSKVTSSTLLKYKQEGRKFTALTAYDASFASAFDGEGIDVLLVGDSLGMVLQGHDDTLPVTTAEIAYHTRCVRRGIERSLLIADMPFMSYATPEQAMENATALMQAGANMVKLEGGHWLLETVTKLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDAENAQRILDEAKALEAAGAQLLVVECIPESLATAITQALTIPVIGIGAGATTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEIRSAVRAYIEEVANGTFPSSEHTFS
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH1_SHEB2
Sequence: MALSEAAVKVQAALLERGLETPMLPSVYSSEERKDKIEHHMKEILTLMSLDLSDDSLADTPRRIAKMYVDEIFSGLDYANFPKITVIDNKMGFDEMVRVQDISLTSTCEHHLVTIDGTATIAYLPRKKIIGLSKINRIVRFFAQRPQVQERLTQQVLVALQTLLETKDVAVKMDAVHYCVKSRGVMDSTSSTTTTALGGIFKSNPATRAEFLHQSK
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: KL61_DROME
Sequence: MDISGGNTSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMHSVQELSETETIMNSTPIEPVDGVTVKRGCGTTRNSNSNALKPPVATGGKRSSSLSRSLTPSKTSPRGSPAFVRHNKENVA
What is the function of this protein?
Important role in mitotic dividing cells (PubMed:8227131).  Microtubule motor required for spindle body separation (PubMed:8918872).  Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function (PubMed:8918872, PubMed:8589456, PubMed:19062285).  Forms cross-links between microtubules within interpolar microtubule bundles (PubMed:9885249, PubMed:19158379).  Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinetochore spacing, and anaphase A rates (PubMed:19158379).  Displays microtubule-stimulated ATPase activity (PubMed:8589456).  Required for normal fusome organization (PubMed:10469596).  Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).
What are the official names of this protein?
Kinesin-like protein Klp61F, Bipolar kinesin KRP-130.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm. Note=In somatic cells, cytoplasmic during interphase, localized to centrosomal asters at the onset of mitosis in prophase and associated with spindle structures during the remainder of mitosis (PubMed:10469596). In male and female germ cells, associates with fusomes during interphase, then localizes to centrosomal asters during prophase and to spindles in metaphase (PubMed:10469596). Coincident with spindle microtubules from prophase to metaphase and, as mitosis proceeds, found both at the spindle poles and along the spindle fibers (PubMed:8589456).
Protein: OPGD_SALTY
Sequence: MNRRRFIKGSMAMAAVCGSSGIASLFSQAAFAAESDIADGKIVRFDFAGLQSMAQALAKKPWGGAPGPLPDTLANLTPQAYNSIQYDAAHSLWNGVANRQLDIQFFHVGMGFRRRVRMFSVDTTTHLAREIHFRPELFKYNDAGVDTTQLEGQSDLGFAGFRVFKAPELARRDVVSFLGASYFRAVDDTYQYGLSARGLAIDTYTDGQEEFPDFTAFWFDTAKPGDTTFTVYALLDSASVTGAYKFVIHCEKSQVIMDVENHLYARKDIKQLGIAPMTSMFSCGNNERRVCDTIHPQIHDSDRLAMWRGNGEWICRPLNNPQKLQFNAYMDDNPKGFGLLQLDRDFSHYQDVMGWYNKRPSLWVEPRNKWGKGAVSLMEIPTTGETLDNVVCFWQPEKAIKAGDTLAFNYRLYWSAQPPVQSPLARVMATRTGMGGFPEGWAPGEHYPDKWARRFAIDFVGGDLKAAAPKGIEPVITLSSGEAKQIEILYVEPFDGYRIQFDWYPTSDSTAPVDMRMFLRCQGEAISETWLYQYFPPAPDKRRYVDDRIMR
What is the function of this protein?
Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TENA_STAES
Sequence: MTFSKELREASRPIIDDIYNDGFIQDLLAGKLSNQAVRQYLRADASYLKEFTNIYAMLIPKMSSMEDVKFLVEQIEFMLEGEVEAHEVLADFINEPYEEIVKEKVWPPSGDHYIKHMYFNAFARENAAFTIAAMAPCPYVYAVIGKRAMEDPKLNKESVTSKWFQFYSTEMDELVDVFDQLMDRLTKHCSETEKKEIKENFLQSTIHERHFFNMAYINEKWEYGGNNNE
What is the function of this protein?
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.  Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP).  Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant.  Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the environment, rather than in thiamine degradation.
What are the official names of this protein?
Aminopyrimidine aminohydrolase, Thiaminase II.
What is the protein family that this protein belongs to?
Belongs to the TenA family.
Protein: OGT_SACS2
Sequence: MLVYGLYKSPLGYITVAKDDKGFIMLDFCDCVEGNSRDDSSFTEFFHKLDLYFEGKPINLREPINLKTYPFRLSVFKEVMKIPWGKVMTYKQIADSLGTSPRAVGMALSKNPILLIIPCHRVIAENGIGGYSRGVKLKRALLELEGVKIPE
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_PROM3
Sequence: MAKGGNKKATAAARAAANRLLADNRLARHQYEILDTLETGIELVGTEVKSIRAGQANLRDGFCLIRKGELQLHNVHISPHSHAGSYFNHDPLRTRKLLAHRREIDKLRGQLDRKGLTLIPLNLHLKGSWIKLTIGLGKGRKLHDKRQEEKRKQADREVKSALARY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: YAAI_ECO7I
Sequence: MKSVFTLSASLAISLLLCCTAQANNHKILGVIAMPRNETNDLALKLPVCRIVKRIQLTADHGDLQLSGAAVYFKAARSASQSLNIPSEIKEGQTTDWININSDNDNKRCVSKITFSGHTVNSSDMATLKIIGDD
What are the official names of this protein?
UPF0412 protein YaaI.
What is the protein family that this protein belongs to?
Belongs to the UPF0412 family.
Protein: Y1353_DESAP
Sequence: MLGVDEIIQTIKMIQEENLDIRTITMGVSLLDCAASDPVAVCDKVHRKVTRLAGRLVEIGNEIEREYGIPIVNKRIAVTPVALIIGEMGRDGCLALARTLDRAAAEVGVNFIGGYSTLVHKGFTRGDRELIASLPEALAATERVCASVNVATSKAGINMDAVRLMGAVIKETAARTADRSAIGCAKLVVFANAPEDNPFMAGAFHGVGEPECVINVGVSGPGVVKNAVARLPDADLGALAEEIKKTAFKITRMGELVGRETAKRLGVPFGIVDLSLAPTPAVGDSVAEIIEALGVEACGAPGTTAALALLNDAVKKGGAMASSRVGGLSGAFIPVSEDAGMIRAVAAGALGLDKLEAMTAVCSVGIDMVALPGDTSAETIAALIADEITIGVVNHKTTAVRLIPVPGKRAGEFVEFGGLLGRTPIMEVNHFGAAKFVHRGGRIPAPISSLNN
What are the official names of this protein?
UPF0210 protein Daud_1353.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: SUCC_SHESM
Sequence: MNLHEYQAKSLFAEYGLPVSEGFACDTAQEAVEAAGRIGGNLWVVKCQVHAGGRGKAGGVKVTGDKEEIRAFAEHWLGKNLVTYQTDEKGQPVAKILVESCTDIANELYLGAVVDRATRRVVFMASTEGGVEIEKVAEETPELIHKAIIDPLTGPQPYQARDLGFKLGLNPTQMKQFTKIFMGLATMFVDHDFALLEINPLVITTEGNLHCLDGKIGIDGNALFRQPKIKAMHDPSQDDAREAHAAMFELNYVALDGNVGCMVNGAGLAMGTMDIVNLHGGKPANFLDVGGGATKERVAEAFKIILSDSNVKAVLVNIFGGIVRCDMIAEGIIGAVKEVGVKVPVVVRLEGTNAELGREVLAKSGLDIIAANSLTDAAEQVVKAAEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: MOV10_MOUSE
Sequence: MPSKFSCRKLRETGQRFESFLAERGLDLETDRERLRTIYNHDFKPSYGTPAPGFSSMLYGMKIANLAFVTKTRVRFFKLDRWADVQLPEKRRIKPGSNISKQHRSLLARIFHDRAEYLHGKHGVDVEVQGPHEARDGQLLIHLDLNRKEVLTLRLRNGGSKPVTLTHLFPLCWTPQFVFYHGEQDLPCPLGPGESYELHIYCKTSIVGYFPATVLWELLGPGESGAEGAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNSVLTNRIEEGERPDRAKGYELELSLALGTYYPPILLRQLLPTLLQGPSIFTAPKEVAEIKAQLETTLKSRNYEVKLRLLLHLEELQMEHDIRHYDLDSVPMTWDPVDQNPRLLTLEVPGVAESRPSVLRGDHLFALLSSETQQDDPVTYKGFVHKVELDRVKLSFSTSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWVLWPMLFPVASRGVSLLPSDVKFKLYDRSLESNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKTCCNWDAKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKQLLAPSSKKGKARLSPRNVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPSTSGPRRHQNLPQEREGEGGLPLQVEPEWRNEL
What is the function of this protein?
5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission.  Plays an important role in innate antiviral immunity by promoting type I interferon production.  Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation.  Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs.  Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC).  Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC.  In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2.  Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1.  Facilitates LINE-1 uridylation by TUT4 and TUT7 (By similarity).  Required for embryonic viability and for normal central nervous system development and function.  Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (PubMed:28662698).  May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity).
What are the official names of this protein?
Putative helicase MOV-10, Moloney leukemia virus 10 protein.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Nucleus. Cytoplasm. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, Stress granule. Note=In young mouse (P2) neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (PubMed:28662698). Co-enriched in cytoplasmic foci with TUT4 (By similarity).