PharMolix/UniProtQA huggingface dataset:
Protein: SYGB_ACIBT
Sequence: MSKHTVLFELGCEELPPKSLKTLRDALQAETVKGLNEAGLDFASVEAYAAPRRLALKIVDVDAAQADTQKRFDGPAVQAAYDAEGKPTKALEGFMRGQGITVDQLSTFQAGKVEKVCYLKDVKGQSLDALLPQILQTALDNLPIAKRMRSAASRTEFVRPVKWVVLLKDDQVIEATIQDHKAGNVTYGHRFHAPEAVTLAHANDYLAALEKAYVVANFEKRQATIQEQVKKLADEVNATAIVPADLLDEVTSLVEWPVALRATFEERYLAVPQEALITTMQDNQKYFCLINAEGKLQPYFITVSNIESKDSTQIIEGNEKVVRPRLSDAEFFFLQDQKQPLASRKEKLANMVFQAQLGTLWDKSTRIAKLAVALSSITGANPADAEKAALLAKCDLTSELVGEFPELQGIAGTYYARIEGENTEVSEALGEQYLPKFAGDVLPKTKTGTTIALADRLDTLVGIFGIGQAPTGSKDPFALRRSAIGILRLIIENELDVTIEELVNLALQGYGDIVKDHDKTRADAVAFLEGRYRAKYEDQGVAVDVLQAVQALAPKSPLDFDKRVNAVNHFRTLPEAAALAAANKRVANILAKEAAPEGSVIEANLVEDAEKALFAELQAVTPVVEPLLAAKDYTAALSKLAALRAPIDAFFDGVMVMADDADLKANRLRLLAQLRNLFTAVADVSVLQG
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y179_YERPE
Sequence: MIIPWQQVDSETLDNLLEAFVLREGTDYGEHERSLTEKVADVRRQLVSGEAVLVWSELHETINIMPRGSFRAGAEEQQ
What are the official names of this protein?
UPF0270 protein YPO0179/y3960/YP_0178.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: RS11_BRASB
Sequence: MAKEATRVRRRERKNIASGVAHVNSSFNNTTITITDAQGNTIAWSSAGTMGFKGSRKSTPYAAQVAAEDVSKKAQEHGMRTLEVEVAGPGSGRESALRALQAAGFTVTSIRDVTTIPHNGCRPRKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: FTSZ1_ARCFU
Sequence: MFMKSIVEEALARAEREKKERIEGRGFEDVEDEILQVLHELKTVIKVIGVGGGGCNTITRMYEEGIEGAELIALNTDVQHLYYTKANRRILIGKRRTRGLGAGSLPQVGEEAARESEDEIKKLVEGSDMVFVTCGLGGGTGTGAAPVVAEAAQEAGALTIAVVTFPFSAEGAVRRANAEAGLERLREVADTVIVIPNDRLLEVVPNYPMQLAFKVADEILMRAVKGITELITKPALINLDFADVRTVMEKGGVAMIGLGEASGEDKAAESVRKALKSPLLDVDVSGAKAALVNVTGGPDMTIEEAESVIEEIYSKVDPDARIIWGAMIDPELENTMRTLIIVTGVKSPQILGRKGYPVTRKYGIDFVR
What is the function of this protein?
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.  The regulation of the ring assembly controls the timing and the location of cell division.  One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells.  Binds GTP and shows GTPase activity.
What are the official names of this protein?
Cell division protein FtsZ 1.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Protein: MMPLB_MYCBO
Sequence: MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSADVRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKALDQVQLAYRNGIARAISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPVETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPGRQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR
What are the official names of this protein?
Probable transport protein MmpL11.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TLP5_GLECO
Sequence: ANFDIINQXPYTVXAAASPGGGRRLETGQSXXLQVAPGTTXAAI
What are the official names of this protein?
Thaumatin-like protein 5, CTLP5.
What is the protein family that this protein belongs to?
Belongs to the thaumatin family.
Protein: L1CA1_DANRE
Sequence: EFRQRDPSPSFRWVKDGKQFGEVLSESGTLTPHPTMDLHFYQGTYRCYAANELGTAVSNLVHLTTEPVPSLAKVKKQKRRAYEVGESAVLRCNPPKSSVTPKIHWMDMQFHHIPLNERVTISRDGNLYFANLIANDSRDDYTCNAHYINASIILPKEPMSIYVTPSNSVVKNRRAKLHHPAGARSSYLVLRGQTLTLQCIPEGLPTPEVHWDRIDSALSPNRTKKLYNNRWLQIDNVLESDDGEYVCTARNSENSVKHHYTVTVEAAPYWTRSPEEHLYAPGETVRLDCKADGIPAPNITWSINGVPVSGTDVDPRRRVSSGKLILSNVEFSDTAVYQCEAVNKHGSILINTHVHVVELPAQILTPDERLYQATAGQTVMLDCRTFGSPLPKIHWEILDSIPALSNAKISQTTNGSLKISNVSEEDSNRYTCSVSETNKSISADVEVLNRTKIVGPPQNLHVIRGSDAILHCKYTVDHNLKSPTVQWNKDGHKITASTSNDKYHEIEGSLKVLDVQMEDMGIYSCEVSTTLDSDTASGYITVQDKPDPPQSLKLSEKMERSVTISWMPSVENNSPVTEYVIEMNEGETPDEGQWQKYRSVSQDIDSWRSICSYSKYHFQIRAVNSIGTSAPTESSLSYSTPAAKPDTNPENVMTLSTDPKSMIISWQEMDRRQFNGPGFQYKVFWRRAADSGAHWTESSVSNPPLMVNNTGTFVSFEIKVQAVNDLGAAPEPLTVIGYSGEDFPLEAPSALSVTELQKTSVMVRWSPVRPESVRGHLLGYKIYLRMKGSQWETPGRAVSSSGNPTVIEVPADAAEKIVSDLQFYSDYTLTITAFNSKGEGPHSEESFSTPEGAPGPVLFLPFDSPSESEITLRWEAPHKPNGEIRGYLLQYQEVVIGSESPQHVESIDLPAVTEFTLKNLNPESRYTFHLSARNDAGDGAPAIQSGATLLDGEPPSVINMTAGETSVNLSWVPGDRHRNLGFSFRYLKKIEGAEWEESEKINSTQAFYQLQGLDSGVIYHLQVLSGNTSYDWDFKTIYSPEWHKSPRNFATEGWFIGLISALVLLLLVLLLLCYIKKSKGGKYSVKDKEEGQGDAANQKLKDDAFGEYRSLESDMEKCSISQPSGCESKRSSNDSLADYGDSVDIQFNEDGSFIGQYSGRRDPRGHDSSGAVSPVNPNMPPPSHSFPTSVTGILGPN
What is the function of this protein?
Cell adhesion molecule with an important role in the development of the nervous system.  Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.  Binds to axonin on neurons (By similarity).
What are the official names of this protein?
Neural cell adhesion molecule L1.1, N-CAM-L1.1, NCAM-L1.1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, growth cone.
Protein: RL21_SHIBS
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: MIEAP_CHICK
Sequence: MAGSLKKLAKAESCRLMQEKLESWSKDYEINSCDQNLNQCCELIEMTSVIQGQLFTILNETSRESGHYAGVDTIKTRLLPWLGTWFSHATSGRLFETGLFLNQDSTETERKLRQLATSQTLQLQDLQEELTSTRLELNHVQQDLAQTQLALEDTKTQLATTLLTAADEIIQLRAVLKASRAQEEDSLRRLDHLNDCEQQIERLRDELSILDAQKSVLQSRIARSRSPSPRRIRSRSPSPLPLRSCSPGRARSTNASRHAFLVARFGDIYSKDRFDAERILRTYISDMEMVQRIIYTAAVESFHAAKMAYRQFKMRVRKTLSIGHSGPESLEDTVMDYIVRHEDLYDVQASVNEVIRSMNINPKISSTPECDFAVISSFIRELCRVAFSMQTLTPPLDVAFGMDGEFFSETKYHRSVDSDYTAALVAYHVWPALMENDVVIVKGEAVTKRGALWSHRSRSRSQNRSRSVSPLLSHLSRSR
What is the function of this protein?
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage.  Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen.  Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity).  The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).
What are the official names of this protein?
Mitochondria-eating protein, Spermatogenesis-associated protein 18.
What is the protein family that this protein belongs to?
Belongs to the MIEAP family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane.
Protein: MNTR_OCEIH
Sequence: MPTPSMEDYIEIIYNLIESKGYARVSAIAEALDVHPSSVTKMVQKLDKDQYLDYEKYRGFVLTSKGKKIGERLVFRHELLEEFLEIIGVNDENIYDDVEGIEHHLSWNSIDRIGDLVNYFKDDDSRVKDLKKVIKESDQQVNETAEK
What is the function of this protein?
Central regulator of manganese homeostasis.
What are the official names of this protein?
HTH-type transcriptional regulator MntR, Manganese transport regulator.
What is the protein family that this protein belongs to?
Belongs to the DtxR/MntR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MACB_CAMJR
Sequence: MIFLKNICKNIGENAILKNVSLSIEKGEFVAIIGQSGSGKTSLLNIIGTLDTPSSGTYVFDEYEVTKLNNDEKARLRREKIGFIFQRYNLLSLLSAKENVSLPAVYAGKNLQERSQNAKKLLNDLELAHKLDSKPNELSGGQQQRVSIARALINGGELILADEPTGALDSKSGIMVLEILQKLNEQGHTIVLVTHDPKIAAQAKRVIEIKDGEILSDTKKEKAQEKLILKTMPKEKKTLTLLKNQAFECFKIAYSSILAHKLRSILTMLGIIIGIASVVCVVALGLGSQAKVLESIARLGTNTIEIRPGKGFGDLRSGKTRLNFSDLETLRSLEYLEAVDAHSNTSGVATYTNISLSARAEGVGVNNFAIEGLRIDAGRILNNDDVKNSTNVAVLDFNAKKNLFPDEKSENILGRVVLFNSQSFKIIGVLQKDTDKPIEDNVVRLYIPYTTLMNKLTGDRNLREIIVKVKDDVSSTLAENAIIRILEIKRGQKDFFTFNSDTFKQAITANKRTTTILTACVAVIALIVGGIGVMNIMLVSVSERTREIGIRMAIGARREDIMMQFLIEAVMICTIGAILGVILSIFVIFAFNTLSTDFPMILNAYSVLLGLLSSMFIGVVFGFFPARNAANLNPISALSKE
What is the function of this protein?
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRUA_CERS5
Sequence: MPRYALKIEYDGAPFAGWQRQAVLPSVQGAIEAALGRLEPGPHTIAAAGRTDTGVHATGQVAHCDLGKDWDPFRLAGALNAHLKPLPVAVVAAARVGEDFHARFSAIERRYLFRLLARRAPEVHDRGRVWRVPHPLDGAAMREAAAHLVGRHDFTTFRAIGCQAASPVKTLDELTLETVEVPNGVEYRFRLRARSFLHNQVRSIVGTLERVGAGAWAPDRVKEALEARDRAACGPVCPPQGLYLTGVGYPADPFAAT
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: CYB_CTEAR
Sequence: MTNTPKSHPLIKIMNHSFIDLPAPSNISAWWNFGSLLGLCLGLQILTGLFLAMHYTADTTTAFSSVTHICRDVNYGWLIRYMHANGASMFFIFLYLHIGRGIYYGSYTFTNTWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGPTLVEWIWGGFSVDKATLTRFFAFHFILPFIITAMVMIHLLFLHETGSNNPSGVNSDSDKIPFHPYYTIKDVLGILFMMITLMSLVMFTPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILTLFPILHSSKQRSMSFRPLSQCLMWMLVANLLILTWIGGQPVEHPFITIGQLASVTYFFTILILMPSTALMENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PANB2_ALIF1
Sequence: MKKITISDLNNWKEVGEKFASITAYDASFAKIFEEQSMPVIIVGDSLGSVIQGKPTTLDVSIEELVYHTKCVRAGSPNAFIISDLPFMSYHTPEAACGSAAKLMKAGANMVKIEGGSWLINTVKMLTERAVPVCAHLGLMPQAVNIYGGYKLQGKTEEQATKMLENAKELQRAGAQALILECIPAKLARQITLELHIPVIGIGAGNDTDGQVLVMHDILGISANYIPRFSRNFLAETGSIEAAVKKYIDEVKQQTFPGEKHCF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase 2, Ketopantoate hydroxymethyltransferase 2, KPHMT 2.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_SHESA
Sequence: MSATSIQPLLDILFLGKALTREQTASLFSTLIQGEMNEAVMAAMLMALKIRGETIAEISGAADAMRAAAKPFPYPASSRSQGIIDIVGTGGDGFNTINISTTAAFVAAAAGAKVAKHGNRSVSSKSGSSDLLAQFGIDLTMSPELASRCLESLNLCFLFAPHYHGGVKHAVPVRQALKTRTLFNVLGPLINPARPEFMLLGVYSPELVTPIARVLQALGTQRAMVVHGSGLDEVALHGSTQVAELKDGEIIEYQLTPADFGVPQAQISELEGGEPAQNAQITQSILQGQGSDAHTHAVAINAGCALYLCGLSDSVKAGTALALNTIKSGKAFELLNQLAKVSSEAQE
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: IDI2_STAAW
Sequence: MSDFQREQRKNEHVEIAMAQSDAMYSDFDKMRFVHHSIPSINVNDIDLTSQTPDLTMAYPVYINAMTGGSEWTKNINEKLAVVARETGLAMAVGSTHAALRNPRMAETFTIARKMNPEGMIFSNVGADVPVEKALEAVELLEAQALQIHVNSPQELVMPEGNREFVTWLDNIASIVSRVSVPVIIKEVGFGMSKELMHDLQQIGVKYVDVSGKGGTNFVDIENERRANKDMDYLSSWGQSTVESLLETTAYQSEISVFASGGLRTPLDAIKSLALGAKATGMSRPFLNQVENNGIAHTVAYVESFIEHMKSIMTMLDAKNIDDLTQKQIVFSPEILSWIEQRSLNIHRG
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CATV_NPVHC
Sequence: MNKIVLCLLVFCVAHSAAYDLLKAPSYFEDFLHKFNKHYSSESEKLRRFQIFQHNLEEIIIKNQNDTTAQYEINKFSDLSKDETISKYTGLALPLQTQNFCEVVVLNRPPDKGPLEFDWRRLNKVTSVKNQGICGACWAFATLASLESQFAIKHNQLINLSEQQLIDCDYVDAGCNGGLLHTAYEAVMQMGGVQAENDYPYEGSDGNCRVDVAKFVVKVKKCYRYIAVFEEKLKDLLRIVGPIPVAIDASDIVNYRRGIMRYCSNYGFNHAVLLVGYGVENNVPYWILKNTWGEDWGEQGYFRVQQNINACGIRNELLASAEIY
What is the function of this protein?
Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus.  May participate in the degradation of foreign protein expressed by the baculovirus system (By similarity).
What are the official names of this protein?
Viral cathepsin, V-cath, Cysteine proteinase, CP.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: CAPSD_BPXF
Sequence: SGVGDGVDVVSAIEGAAGPIAAIGGAVLTVMVGIKVYKWVRRAM
What is the function of this protein?
Self assembles to form a helical capsid wrapping up the viral genomic DNA.  The capsid displays a filamentous structure with a length of 760-1950 nm and a width of 6-8 nm.  The virion assembly and budding take place at the host inner membrane (By similarity).
What are the official names of this protein?
Capsid protein G8P, Coat protein B, Gene 8 protein, G8P, Major coat protein.
What is the protein family that this protein belongs to?
Belongs to the inovirus capsid protein family.
What are the subcellular locations of this protein?
Virion. Host membrane; Single-pass membrane protein. Note=prior to assembly, the major capsid protein is found associated with the bacterial host inner membrane.
Protein: PTMH_PENSI
Sequence: MERRTVLITGCSQGGIGSALAEAFHQRGFHVFATARKTEKMTHLRDLDWMTLIPLDVTQESQISAAVELIQKHTGGTLDYLVNNAGDGYIIPVLDCDQVHGRQIFEVNFWGPLRMIQEFSPLLIAARGTIVNINSVASETLPLWLGIYSSSKAALLALSETLRLELKPFGVQVLSVMTGAVQTMIFQTNYRLPPDSAYVAWEKQIAAQAEGSEQASRMSATVYAERVVGDILNRRGGITYRGQMASFAYWVVALMPRFLRDLVTVKMAGIS
What is the function of this protein?
Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:25831977).  The geranylgeranyl diphosphate (GGPP) synthase ptmG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:25831977).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase ptmC then forms 3-geranylgeranylindole (3-GGI) (PubMed:25831977).  Epoxidation by the FAD-dependent monooxygenase ptmM leads to a epoxidized-GGI that is substrate of the terpene cyclase ptmB for cyclization to yield paspaline (PubMed:25831977).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase ptmP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase ptmQ (PubMed:25831977).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase ptmH which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase ptmD (PubMed:25831977).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase ptmV and ptmI leads to the production of the prenylated form of penijanthine (PubMed:25831977).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase ptmE (PubMed:25831977).  Five sequential oxidative transformations performed by the cytochrome P450 monooxygenases ptmK, ptmU, ptmL, ptmN and ptmJ yield the various penitrem compounds.  PtmK, ptmU and ptmM are involved in the formation of the key bicyclic ring of penitrem C via the formation of the intermediates secopenitrem D and penitrem D.  PtmL catalyzes the epoxidation of penitrem D and C to yield penitrem B and F, respectively.  PtmJ catalyzes the last benzylic hydroxylation to convert penitrem B to prenitrem E and penitrem F to penitrem A (PubMed:25831977).
What are the official names of this protein?
Short-chain dehydrogenase ptmH, Penitrem biosynthesis cluster 1 protein H.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: TVP23_ASPNC
Sequence: MEQQPLQPQQGELNWRLSAHPITLLFFLGFRIGALLMYLFGVLFIKNFVLVFIITLLILSADFYYLKNIAGRRLVGLRWWNEVNTSSGDSTWVFESSDPTTRTITATDKRFFWLSLYVTPALWIGLAILAIIRLSSVIWLSLVAIALALTITNTVAFSRCDRFSQASTFANSALSGGVMSNLAGGLLGRLFK
What is the function of this protein?
Golgi membrane protein involved in vesicular trafficking.
What are the official names of this protein?
Golgi apparatus membrane protein tvp23.
What is the protein family that this protein belongs to?
Belongs to the TVP23 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: RRF_POLNA
Sequence: MSIVEIKQQATQKMQQSLESFQHNLTKIRTGRANPGLLDTVHVDYYGSMVPISQVANVALLDARTISVSPWEKGMGAKIEKAIRDSDLGLNPASQGDLIRVPMPAMTEERRKELTKVVRAEGEHAKVAIRNLRRDANDGVKKLVKDKLASEDDERRSQEEIQKFTDRFIADVDKLVTGKEQDIMAV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHMA_ECOL6
Sequence: MNALLTNPFKERLRKGEVQIGLWLSSTTAYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQLQAVAPYASHPVIRPVEGSKPLIKQVLDIGAQTLLIPMVDTADQARQVVSATRYPPYGERGVGASVARAARWGRIENYMAQVNDSLCLLVQVESKTALDNLDEILDVEGIDGVFIGPADLSASLGYPDNAGHPEVQRIIETSIRRIRAAGKAAGFLAVAPDMAQQCLAWGANFVAVGVDTMLYSDALDQRLAMFKSGKNGPRVKGSY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
What are the official names of this protein?
2-keto-3-deoxy-L-rhamnonate aldolase, KDR aldolase, 2-dehydro-3-deoxyrhamnonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.
Protein: EFP_VIBVU
Sequence: MATVSTNEFKGGLKLMIDSEPCVILENEYVKPGKGQAFNRVKIRKLLSGKVLEKTFKSGDTCEVADVMDIDLDYLYSDGEFYHFMNNETFEQIAADAKAVGENVKWLVENNTCMLTLWNGNPIAVTPPNFVELEVIETDPGLKGDTQGTGGKPATLSTGAVVRVPLFIQIGEVIKVDTRSSEYVGRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_RICAE
Sequence: MSTINTDTNETMPHVSVNAQYIKDLSLENPSAPSSLAALDQRPQIDLSLDINITNLSEENFYEVELNIEAIARNEKYKLFQIELKYAGVFNLINIDSEQHPVLLSVHCPAMIFPFARKIIASCTQDAGFQPLMIDPIDFGALYHKKMSEHQN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_SHESA
Sequence: MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVAAKMLHLTKEQAEGFYAEHSERGFFGALVAFMTSGPIMVQVLEGENAVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSDALESAAREIAYFFSAEELCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.