PharMolix/UniProtQA huggingface dataset:
Protein: TFAM_PIG
Sequence: MALLRGVWGVLSALGKSGADLCAVCGSRLRSPFSFAYVPRWFSSTLSGFPKKPMTSYVRFSKEQLPIFKAQNPDAKNSELIKKIAELWRELPDSEKKIYEDAYRADWQVYKEEVNRIQEQLTPSQMVSLEKEIMQKRLKKKALIKKRELTMLGKPKRPRSAYNIFIAERFQEAKDGPSQVKLKTINENWKNLSSSQKQVYIQLAEDDKVRYYNEMKSWEEQMVEVGRNDLIRRSMKHSAKKDTEEC
What is the function of this protein?
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation.  Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA.  In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand.  Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase.  Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites.  Is able to unwind DNA.  Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes.  Required for maintenance of normal levels of mitochondrial DNA.  May play a role in organizing and compacting mitochondrial DNA.
What are the official names of this protein?
Transcription factor A, mitochondrial, mtTFA.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.
Protein: ERD2_PETHY
Sequence: MNIFRLAGDMTHLASVLVLLLKIHTIKSCAGVSLKTQELYALVFVTRYLDIFTDFISLYNTTMKLVFLGSSLSIVWYMRHHKIVRRSYDKDQDTFRHLFLVLPCLLLALVINEKFTFKEVMWTFSIYLEAVAILPQLVLLQRTRNIDNLTGQYIFLLGAYRSFYILNWVYRYFTEPHFVHWITWIAGLIQTLLYADFFYYYFQSWKNNTKLELPA
What is the function of this protein?
Required for the retention of luminal endoplasmic reticulum proteins.  Determines the specificity of the luminal ER protein retention system.  Also required for normal vesicular traffic through the Golgi.  This receptor recognizes H-D-E-L (By similarity).
What are the official names of this protein?
ER lumen protein-retaining receptor, HDEL receptor, PGP169-12.
What is the protein family that this protein belongs to?
Belongs to the ERD2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL19_UREP2
Sequence: MALFKINKGEIMNFVNSTQLKTDIPNFDSGDTIIVHNRIVEGKKSRIQKFEGVVLRRRGSGSSETVIVRKESSGIGVEQSFNIHSPLVEKIEVIKYGKVRRAYISYMRNRSGKSARIKELNKQ
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RIMO_METS4
Sequence: MHPLMSAAPKISFVSLGCPKALVDSERILTHLRAEGYELARKHDGADVVIVNTCGFLDSAKAESLQAIGEAMAENGRVIVTGCMGAQPEEIRERYPNLLAVTGPQAYESVVAAVHEAVPPAHDPYLDLVPPQGVKLTPRHYAYLKISEGCNNRCTFCIIPSLRGDLVSRPAGDVLREAEKLVKAGVKELLVISQDTSAYGVDLRYAASPWRDGEVRARFVDLARALGELGVWVRLHYVYPYPHVDEVIPLMAEGKVLPYLDMPLQHASPSVLRRMRRPANQEKMLERIRGWRSVCPDLAIRSTFIVGFPGETEAEFEELLSWLAEAKLERVGCFPYEPVRGAAANEVAPPVPDEVKAERYRRFMEAQAAVSLRLQRAKVGKRLPVIIDEAGPTVARGRSKSDAPEIDGSVHVASRRPVRAGDIVTVKIERADTYDLHGIAV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP_RHOJU
Sequence: KEGYPDGQNGKKIPCAINDNISKTXEQA
What is the function of this protein?
Causes symptoms of mild intoxication and transient paralysis in insects (A. domestica).
What are the official names of this protein?
Venom protein.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPA_ORYSJ
Sequence: MATLRVDEIHKILRERIEQYNRKVGIENIGRVVQVGDGIARIIGLGEIMSGELVEFAEGTRGIALNLESKNVGIVLMGDGLMIQEGSFVKATGRIAQIPVSEAYLGRVINALAKPIDGRGEIVASESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQKGQDVICVYVAIGQRASSVAQVVTTFHEEGAMEYTIVVAEMADSPATLQYLAPYTGAALAEYFMYRERHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNSLLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKSKLELAQFAELQAFAQFASALDKTSQNQLARGRRLRELLKQSQANPLPVEEQIATIYIGTRGYLDSLEIGQVKKFLDELRKHLKDTKPQFQEIISSSKTFTEEAEILLKEAIQEQLERFSLQEQT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: CYSI_ECOHS
Sequence: MSEKHPGPLVVEGKLTDAERMKLESNYLRGTIAEDLNDGLTGGFKGDNFLLIRFHGMYQQDDRDIRAERAEQKLEPRHAMLLRCRLPGGVITTKQWQAIDKFAGENTIYGSIRLTNRQTFQFHGILKKNVKPVHQMLHSVGLDALATANDMNRNVLCTSNPYESQLHAEAYEWAKKISEHLLPRTRAYAEIWLDQEKVATTDEEPILGQTYLPRKFKTTVVIPPQNDIDLHANDMNFVAIAENGKLVGFNLLVGGGLSIEHGNKKTYARTASEFGYLPLEHTLAVAEAVVTTQRDWGNRTDRKNAKTKYTLERVGVETFKAEVERRAGIKFEPIRPYEFTGRGDRIGWVKGIDDKWHLTLFIENGRILDYPGRPLKTGLLEIAKIHKGDFRITANQNLIIAGVPESEKAKIEKIAKESGLMNAVTPQRENSMACVSFPTCPLAMAEAERFLPSFIDNIDNLMAKHGVSDEHIVMRVTGCPNGCGRAMLAEVGLVGKAPGRYNLHLGGNRIGTRIPRMYKENITEPEILASLDELIGRWAKEREAGEGFGDFTVRAGIIRPVLDPARDLWD
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: Y5526_MYXXD
Sequence: MKIWVDADACPGPVRDIILRAGQRVKVHTVFVANHALSLPRLAYVSSVQVGAGLDVADRHIAQQAQPGDLAVTQDIPLAALLVPKGVVVLDPRGEVFTEENVAERLSVRNFMQELRESGVTTGGPDGYSAQDRQQFAGALDRELTRLVKTEPK
What are the official names of this protein?
UPF0178 protein MXAN_5526.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: RBFA_CLOP1
Sequence: MANFRGKRINEEVRKEVSDIIRNQIKDPRLTAMVSVTQVEVTKDLRYAKVFVSLFAKNDEEKEESLKALKSSAGFIRREVGNRVKLRSTPEILFEEDNSIDNAMYIESLLNKIKEK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQ4_ARTOC
Sequence: MSRLKIPSQLLRGGRGFSVLSRPAANYAGHVPLTPVERCTMAVGSAIGSLLNPRRHDLIATLGETTATPYFIYRLRDAMLSDPTGRRILRDRPRITSQTLSLPYLRSLPPTSLGATFASWLDREGVSPDTRSRVRYIDDEECAYVMQRYRECHDFYHAVTGLPIVVEGELALKIFEYMNTGLPMTGLSAAAVVRLKGAERQRFWDVYLPWAVRSGAGSKELICVYWEELLERDVGELRAELGIEVPPDMREMRRRHRKQKQQEKQEK
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4, mitochondrial, Coenzyme Q biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RR3_TUPAK
Sequence: MGQKIHPLGFRLGITQEHRSKWYAKASDYPRLVLEDKKLRDNLFKQYPKANIVDIIIKRRQTTQDLETKESVDVIEVSIYTAVPGKIIGRSKATITELKESLEKLCQLDRMKHNLPQIRIILTILKVQNPYSSASVIADYLIEQLEQRIPFRAALKKALERIRLAKLEGIKIEISGRLNGAEIARSEWVRKGRVPLQTLRADIDYSAKTAKTIYGILGIKVWAFKGERT
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RNPH_BACCR
Sequence: MRVDGREKTELRHIHIHTNYLKHPEGSVLIEVGDTKVICSATIEERVPPFMRGEGKGWVTAEYAMIPRATEQRTIRESSKGKVTGRTMEIQRLIGRALRAVVDLEALGERTVWIDCDVIQADGGTRTASITGAYVAMVLAFEKLLQAEKVSKIPVKDYLAATSVGIVEEQGVVLDLNYAEDSKADVDMNVIMTGKGQFVEVQGTGEEATFSRAQLNELLDAAEQGIFQLIDMQKEALGDIVSHIE
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: LYP6_ORYSJ
Sequence: MAGWPAAEAAGALVVAILAAAAGGAAGKTTIEPCAGADTCAALLGYTLYADMKVSEVAALFGADPRAVLAANALDFASPGAANRILPAGLPLRVPTRCACSDGVRKSVAVRYSARPADTLASVADVVFAGLASADQIRTANGLSAEDPDAPLDAGATLVVPLPCACFNSTDNNLPAVYLSYVVRVGDTVQSIAATHATTVTDISNVNAMGSPIVAPGDILAIPLPACASMFPNSASDYGLLVANGTYALTAGNCVQCSCGPGDLKLYCTPASLTASCSSMQCPNSNLMLGNVTAQSTSGGCNVSSCSYAGLVNGTIATSLSSGLQPTCPGPHQFPPLRATPIAVNQGSYLAPSPAPGAGEAGGDIPGFPGSSNVSPANGPSGSVSQAASVNRPHQIVALILSVALYFQM
What is the function of this protein?
Functions in innate immunity.  Functions as pattern recognition receptor (PRR), sensing bacterial peptidoglycan (PGN) and fungal chitin at the cell surface.  Involved in resistance against the bacterial pathogen Xanthomonas oryzae pv.  oryzae (Xoo) and the fungal pathogen Magnaporthe oryzae.  Binds PGN and fungal chitin in vitro (PubMed:22872757).  Involved in microbe-associated molecular patterns (MAMPs) perception and participates in the activation of defense genes against the bacterial pathogen Xanthomonas oryzae pv.  oryzicola (Xoc) or the fungal pathogen Magnaporthe oryzae (PubMed:23299421).
What are the official names of this protein?
LysM domain-containing GPI-anchored protein LYP6, LysM domain-containing protein 6, Os-LYP6.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: GCST_ECO27
Sequence: MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRTDAGMFDVSHMTIVDLRGSRTREFLRYLLANDVAKLTKSGKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREKDLSWITQHAEPFGIEITVRDDLSMIAVQGPNAQAKAATLFNDAQRQAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIALPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYSQEMDETISPLAANMGWTIAWEPADRDFIGREALEAQREHGTEKLVGLVMTEKGVLRNELPVRFTDAQGNQHEGIITSGTFSPTLGYSIALARVPEGIGETAIVQIRNREMPVKVTKPVFVRNGKAVA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: NUMBL_HUMAN
Sequence: MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL
What is the function of this protein?
Plays a role in the process of neurogenesis.  Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate.  Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis.  Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity.  Negative regulator of NF-kappa-B signaling pathway.  The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
What are the official names of this protein?
Numb-like protein, Numb-related protein, Numb-R.
What are the subcellular locations of this protein?
Cytoplasm. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
Protein: DPS_PECAS
Sequence: MSTAKLVKSAPSELLYTRNDLDDSVKTSTIALLNQLVVDFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTSIIDHQDTIAERVVQIGGVALGTVQIVGKQTSLKSYPTTIHSVQDHLKALAERYAIVANNVRQAIGKTEDEASADILTAASRDLDQFLWFIESNIE
What is the function of this protein?
During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages.  It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction.  One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
What are the official names of this protein?
DNA protection during starvation protein.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_STRPJ
Sequence: MPTINQLVRKPRKSKVEKSKSPALNVGYNSHKKVQTNVSSPQKRGVATRVGTMTPRKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLLRGGHVKDLPGVRYHIVRGALDTAGVNDRKQGRSKYGTKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: PUR5_STRPM
Sequence: MSEKNAYAKSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFGGMFDLSKTGVREPVLVSGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAEPLYFLDYVATGKNNPVKFEEVVSGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAVGVAEKSQLIDGSKVKEGDILLGLASSGIHSNGYSLVRRVFADYTGKELLPELEGKQLKDVLLEPTRIYVRAALPLIKEELINGIGHITGGGFIENVPRMFADDLAAEIDEDKVPVLPIFKALEKYGDIKHEEMFEIFNMGVGLMLAVSPENVNRVKELLDEPVYEIGRIIKKADDSVVIK
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_PSEAB
Sequence: MAAETASGYIQHHLQNLTFGRLPNGDWGFAHTAEQAKEMGFWAFHVDTLGWSVLLGVVFLFIFRLAAKKATSGQPGGLQNFVEVMVEFVDTSVKDTFHGRNPLIAPLALTVFVWIFLLNLIDLVPVDYLPMLAAKITGDEHLFFRAVATTDPNATLGLSISVFALIVFYSIKVKGIGGFLGELTLHPFSSKNIVVQILLIPVNFLLEFVTLIAKPVSLALRLFGNMYAGELIFILIAVMFGSGMFLLSALGVALNWAWAVFHILIITLQAFIFMMLTIVYLSMAHEDNH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DGTL1_HAEI8
Sequence: MQKNEIKQSDMKPLIIDSSWTERFLPDPPREKDNRPPFRRDRGRILHSAAFRCLQAKTQIHAIGENDFYRTRLTHSLEVAQIGSSLVAQLKFLETFESLSQTLNIDKNELQKQLKPLLPSNDLIESLCFAHDIGHPPFGHGGETALNYMMAEQGGFEGNAQTFRILTKLEPYTENAGMNLTRRTLLGVVKYPALLGVASPQYAELNFSRNIDPRFVRIHDWIPGKGIFRDDLKMFNWLLENLSENDRTLFCQFKKVRENPAESLHTRFKSLDCSIMELADDIAYGVHDLEDAIVTGVVNPHQWQAAHVALKQIPSAWLHENIDSISQRLFSDKHFERKQAIGALVNFFITNVRWKLTANFDEPLLRYNAELPPEVIAALGVFKKFVWDYVIRNVDTQRIEYKGQRMLTEMFQIFESDPERLLPRNTENRWRNAPKEGKKRIICDYIAGMSDAHALRVYQQL
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: VE1_HPV34
Sequence: MADSGNWEGRCSGWFNVEAIVERKTGDAIPADENYDGDDTEDSEMGDFIDNAHISNIYSQQEIAQALYHSQQVNADNEAIRVLKRKFAGSAGSSPDSKRHELKHKQRSPHILTIRDTNTTSTHLLCEEQDSGYGNTEVETYERQVPGPGGCLQSTSSSNNGSQMASPGETNSGSSSISNMDIDMESTPITDITNILKSSNVKATLLAKFKEVYGLSYMELVRPYKSDKTQCQDWVCAVFGVAPSLAESLKSLLTQYCLYIHLQCLTCSWGIIVLLLARFKCNKNRLTVQKLLHGLLNVTQEYMLIEPPRLRSTPCALYWYRTSLSNISETVGEVPEWIKRQTVVQHSLEDCQFDLSQMVQWAFDNDITNDCEIAYKYALLASEDSNAAAFLKSNAQAKYVKDCGTMCRHYKAAERKQMTMSQWITHRCDLIDDGGNWKHIVQFLRYQQVEFVPFLIALKQFLKGIPKQNCIVIYGPPDTGKSHFGMSLMQFMQGVVISYVNSNSHFWLSPLADAKMALLDDATPACWTYIDRYLRNALDGNPMCLDRKHKHLLQIKCPPLLITSNTNPKADDTWKYLHSRMKVFTFSNPFPFDSNGNPLYQLTNENWKAFFTKTWSKLDLTEDDDKENDGDTVQTFKCVSGRNPRTV
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: PFKA_ENTCL
Sequence: MIKKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVFGVYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDEHVREVAIENMKKRGLDALVVIGGDGSYMGAKRLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALGTVVEAIDRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFIVVPEVEFSREDLVAEIKAGIAKGKKHAIVAITEHICDVDELAKYIEAETKRETRATVLGHIQRGGSPGPYDRILASRMGAYAIDLLLQGHGGRCVGIQNEKLVHHDIIDAIENMKRPFKGDWLDCAKKLY
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTPG_MYCBO
Sequence: MTTVVDAEVQLTVVSDAAGRMRVQATGFQFDAGRAVAIEDTVGKVAGVQAVHAYPRTASIVIWYSRAICDTAAILSAIIDAETVPAAAVPAYASRSASNRKAGVVQKIIDWSTRTLSGVRRDVAAQPSGETSDACCDGEDNEDREPEQLWQVAKLRRAAFSGVLLTASLVAAWAYPLWPVVLGLKALALAVGASTFVPSSLKRLAEGRVGVGTLMTIAALGAVALGELGEAATLAFLFSISEGLEEYATARTRRGLRALLSLVPDQATVLREGTETIVASTELHVGDQMIVKPGERLATDGIIRAGRTALDVSAITGESVPVEVGPGDEVFAGSINGLGVLQVGVTATAANNSLARIVHIVEAEQVRKGASQRLADCIARPLVPSIMIAAALIAGTGSVLGNPLVWIERALVVLVAAAPCALAIAVPVTVVASIGAASRLGVLIKGGAALETLGTIRAVALDKTGTLTANRPVVIDVATTNGATREEVLAVAAALEARSEHPLAVAVLAATQATTAASDVQAVPGAGLIGRLDGRVVRLGRPGWLDAAELADHVACMQQAGATAVLVERDQQLLGAIAVRDELRPEAAEVVAGLRTGGYQVTMLTGDNHATAAALAAQAGIEQVHAELRPEDKAHLVAQLRARQPTAMVGDGVNDAPALAAADLGIAMGAMGTDVAIETADVALMGQDLRHLPQALDHARRSRQIMVQNVGLSLSIITVLMPLALFGILGLAAVVLVHEFTEVIVIANGVRAGRIKPLAGPPKTPDRTIPG
What are the official names of this protein?
Probable cation-transporting ATPase G.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CABP4_HUMAN
Sequence: MTTEQARGQQGPNLAIGRQKPPAGVVTPKSDAEEPPLTRKRSKKERGLRGSRKRTGSSGEQTGPEAPGSSNNPPSTGEGPAGAPPASPGPASSRQSHRHRPDSLHDAAQRTYGPLLNRVFGKDRELGPEELDELQAAFEEFDTDRDGYISHRELGDCMRTLGYMPTEMELLEVSQHIKMRMGGRVDFEEFVELIGPKLREETAHMLGVRELRIAFREFDRDRDGRITVAELREAVPALLGEPLAGPELDEMLREVDLNGDGTVDFDEFVMMLSRH
What is the function of this protein?
Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission.  Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).
What are the official names of this protein?
Calcium-binding protein 4, CaBP4.
What are the subcellular locations of this protein?
Cytoplasm. Presynapse. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.
Protein: PRRB_MYCTO
Sequence: MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFVPRGLDEIPRSPNDQDALITVRRGNVIKSNSDITLPKLQDDYADTYVRGVRYRVRTVEIPGPEPTSVAVGATYDATVAETNNLHRRVLLICTFAIGAAAVFAWLLAAFAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIWNEQNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKEVLNDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITDLLDRAAHDAARIYPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGATLVQLSAVSSRAGVEIAIDDNGSGVPEGERQVVFERFSRGSTASHSGSGLGLALVAQQAQLHGGTASLENSPLGGARLVLRLPGPS
What is the function of this protein?
Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability.  Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA.  In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression.
What are the official names of this protein?
Sensor-type histidine kinase PrrB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VDH_STRFR
Sequence: MTDASHPTAADDLGALSTLFRSEQGGHERVLLCQDRESGLKAVIALHSTALGPALGGTRFHAYASDEEAVLDALNLARGMSYKNALAGLPHGGGKAVIIGSPAPVSEGGLKSEALLRAYGRFVASLDGRYVTACDVGTYVADMDVVARECRWTTGRSPENGGAGDSSVLTAFGVFQGMRASAQALWGEPTLRGRTVGVAGVGKVGHHLVDHLVEDGARVVVTDVRPESVERVRARHPRVVAVPDTESLIRADLDVYAPCALGGALNDDTVPALTARVVCGAANNQLAHPGVEKDLAGRGILYAPDYVVNAGGVIQVADELLGFDFDRAKAKAAQIFDTTLAIFDRARTDGVPPAVAADRIAEQRMAEARTV
What is the function of this protein?
Oxidative deamination of branched-chain amino acids.  The catabolism of valine is the major source of fatty acid precursors for macrolide biosynthesis and a vital source of antibiotic precursors.
What are the official names of this protein?
Valine dehydrogenase, ValDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
What are the subcellular locations of this protein?
Cytoplasm.