PharMolix/UniProtQA huggingface dataset:
Protein: RF1_VIBVY
Sequence: MKASILTKLEMLVERYEEVQHLLGDPGVIGDQDKFRALSKEYSQLEEVTKCFTAYKQAQEDLVAAEEMAKEDDAEMREMAQEEIKAAKVAIEDLAAELQILLLPKDPNDDRNCFLEIRAGAGGDEAGIFAGDLFRMYSKFAEKRGWRIEVMSANEAEHGGYKEMIAKVNGDGAYGFLKFESGGHRVQRVPATESQGRVHTSACTVAIMPEIPEAEIPEIKASDLKIDTFRSSGAGGQHVNTTDSAIRITHLPTGTVVECQDERSQHKNKAKAMAVLAARIVQAEEAKRAAEVSDTRRNLLGSGDRSDRIRTYNYPQGRVSDHRINLTIYRLSEVMEGDLQSLIDPVIQEHQADQLAALAENN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_SYNP6
Sequence: MLSPRRTKFRKQQRGRMTGKATRGNTLAFGNFGLQALECSWITARQIEASRRAMTRYTRRGGKIWIRIFPDKPITMRPAETRMGSGKGNPEFWVAVVKPGRVLFEIGGEVAEETAREAMRLASHKLPIKTKFITRDSEAQEA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: CUTC_HUMAN
Sequence: MKRQGASSERKRARIPSGKAGAANGFLMEVCVDSVESAVNAERGGADRIELCSGLSEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREIEVMKADIRLAKLYGADGLVFGALTEDGHIDKELCMSLMAICRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIKRLIEQAKGRIVVMPGGGITDRNLQRILEGSGATEFHCSARSTRDSGMKFRNSSVAMGASLSCSEYSLKVTDVTKVRTLNAIAKNILV
What is the function of this protein?
May play a role in copper homeostasis.  Can bind one Cu(1+) per subunit.
What are the official names of this protein?
Copper homeostasis protein cutC homolog.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The overexpressed protein is detected in the cytoplasm, and depending on the cell line, also in the nucleus.
Protein: WHIA_CLOTE
Sequence: MSFSSKVKNEVCRYDELEEKEAMALLSAIMRASGTLTFGRNKGIGFKIATENAAITRLVFKILKNILDIHTNIMIKKSNSFKKNNVYIIVINEEEGVKKLLEKTEVVKIEDIGFFINYNISENLVYDDNTKKAYIRGAFLGGGSVSNPEKTYHLEFVTNNEMYANKLSELINSYGLNSKVIQRKSNFIIYIKEGEQISDLLNIIGAHSSLLQLENIRIMKDMRNNINRIVNCETANLSKTVNAAVRQIESINLINKEIGLKRLPKNLRDMAEIRLKYPDVSLKELGEMLSPPVGKSGVNHRLRRIEKIAEELSKEGNF
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: PUR9_ECOLI
Sequence: MQQRRPVRRALLSVSDKAGIVEFAQALSARGVELLSTGGTARLLAEKGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDAIMEEHQIQPIDMVVVNLYPFAQTVAREGCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYDAIIKEMDDNEGSLTLATRFDLAIKAFEHTAAYDSMIANYFGSMVPAYHGESKEAAGRFPRTLNLNFIKKLDMRYGENSHQQAAFYIEENVKEASVATATQVQGKALSYNNIADTDAALECVKEFAEPACVIVKHANPCGVAIGNSILDAYDRAYKTDPTSAFGGIIAFNRELDAETAQAIISRQFVEVIIAPSASEEALKITAAKQNVRVLTCGQWGERVPGLDFKRVNGGLLVQDRDLGMVGAEELRVVTKRQPSEQELRDALFCWKVAKFVKSNAIVYAKNNMTIGIGAGQMSRVYSAKIAGIKAADEGLEVKGSSMASDAFFPFRDGIDAAAAAGVTCVIQPGGSIRDDEVIAAADEHGIAMLFTDMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: O26X_CONTS
Sequence: VILLMSTQALIQSGVEKRSNKIKALSKRKTTAESWWEGECYGWWTSCSSPEQCCSLNCENIYCRAW
What are the official names of this protein?
Conotoxin TsMEKL-03.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS20_MANSM
Sequence: MTLANIKSAKKRAVQSEKSRQHNASQRSMMRTYIKKVYAAVAAGEKAAAQAAFVEMQKVVDRMASKGLIHANKAANHKSKLVAQIKKLA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: ERPA_ECO7I
Sequence: MSDDVALPLEFTDAAANKVKSLIADEDNPNLKLRVYITGGGCSGFQYGFTFDDQVNEGDMTIEKQGVGLVVDPMSLQYLVGGSVDYTEGLEGSRFIVTNPNAKSTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: T2BLB_BACSQ
Sequence: MEQQKFPNPRIFEDIDATDFSKHNKKHVTEDFVAENFKDVGWRVYRPFNDTGIDLIAKKFVCPDGHTKWNQNLTKEMTCSECGKSLIEITRFIQVKTREVKQVKTREAKGEKFFFGYTLKSKDFRTDPRHVFLLYSDFTMDFIILPMYDYLNLFYTNQSLGSTHFSTPSFRQGNNKLNGLSKDKNDNWVWSGVSFNEFVNEKGMDKLSCPIYDIELESYTKKIQELKFSLFYRYSPGRKNQVSAPTVEFINNHFSIFISLPKEAIASKRKAHLESLRQDLPEDLKKSVNEGYLVKFKGVDL
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-CCN(7)GG-3' and cleaves after N-7.
What are the official names of this protein?
Type II restriction enzyme BslI subunit beta, R.BslIbeta, Endonuclease BslI subunit beta, Type IIT restriction enzyme BslI subunit beta, Type-2 restriction enzyme BslI subunit beta.
Protein: ADDB_STRS2
Sequence: MKLVYTDIRNPLTQYLTEQTATFAEQGKRVFYIAPNSLSFEMERKVLEYLPEQATFDIIVTRFGQLARYLMIDRKEAGQPLDDVGLAMIFFRVLSQFEDGDLKVYGRLQTDFGFINQLVALYKELQRANMSILDLEAMDSPDKQADLVKIFLAVTDILSKEGFEHQSKLAQLTGLVETGQLDEQLKNIVLVVDGFSRFSAEEEALVSALNERVSEILIGVYASKKAVQATYAEGNVYQANVDFLRQLSAQFQTKATYIGQEPVLDSIGKFSKNMEAYYDYSGTMIDLTPADQEKIQLWEVVNQKEEVEQVATAIRQHVHQGARYKDILLLLGDVDSYKLQIGKIFDKYDIPYYFGKAEEMSHHPLVHFVESLERLRRYRFRAEDLLNLLKSGLYASISQKELDLFESYILFADMKGQAAFSRAFSVNGRADYDAEVIKEKRLVYDLTVLEPLRAKIMEPLNQLFKAGPQSGTALLEKFMAFLEAIDLPKNMEKMSRNLSEVEQEKEEQVWKSFTHLLENFHQIFGKEKLKMDDFLAILQAGMQASHYRTVPATVDVVNVKSYDLIEPHTAKYVYAIGMGQSNFPKVAKNTSLLTEEEMEKVNLVSASSSRFDLVSRENIKKNHAAMMSLLNSATEQLVISTPQIYNEGEDSLSPYIKILQKMGLKSEERGRIKTLSPQDIGHYKSLLSRLIESERPSLETEEWEGQRAFWTVLVRHLKKKLESQSIEIPTITGDIASKQLSDETLAALYPEDKPLNLSASSLTNFYNNQYLYFVRNVLRLREQESIHPTAFQHGLFLHRIFERVVMDQSELDFDQKVDKAILRTRDEAEFAMFYNQDADARYTEEVLDKIARSSATILRDNDLVEIDGQEKSFRQDKALVFDLQNGKSVHVNGTIDRLDTLQINQAVGVVDYKSSDQSFSVGDFYNGLKPQLVTYLAALQELDETKDKPVFGAMYLHLQDPIIKLKDTKNLEQLEGAANTSLVYKGLFLKEESLGLNHFYQTRNQLYTEDEFAVLLNHNQELYKQAAMDILAGRFAINPYTKDGRSVAGEQLKAITGFEADRHMGMARRLVKEAKRQDWMERMKGGQD
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: 3L21_BUNCA
Sequence: YTLLCYKTPSPINAETCPPGENLCYTKMWCDAWCSSRGKVIELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG
What is the function of this protein?
Binds to muscular and neuronal nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (Ref. 2, PubMed:30944155).  Reversibly blocks chick and mouse muscle nicotinic acetylcholine receptors (Ref. 2, PubMed:30944155).  Blocks muscle type nAChR with an IC(50)=30 nM, when heterologously expressed in oocytes (PubMed:30944155).  Also binds with high affinity to alpha-7/CHRNA7 nAChRs (PubMed:30944155).  In addition, shows a weak inhibition of neuronal alpha-3-beta-2/CHRNA3-CHRNB2 nAChR (IC(50)=2. 9 uM) (PubMed:30944155).  Selectively binds to alpha-1-delta subunit interface of the mouse muscle nicotinic acetylcholine receptor, with a 10-fold higher affinity for the adult than for the fetal receptors (Ref. 2, PubMed:30944155).  In vivo, when intraperitoneally injected into mice, causes flaccid paralysis and respiratory distress, followed by death within 2-4 hours (PubMed:30944155).
What are the official names of this protein?
Alpha-elapitoxin-Bc2a, Alpha-EPTX-Bc2a, Alpha-delta-Bgt-1, Alpha/delta-bungarotoxin-1, Alpha/delta-BgTx-1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: INF56_UROAP
Sequence: MHCFIIFSVINLALLQLALGASLPTSHATYPQSQPHATKRSFGPAVPSSVNGFGPFGSTYISANQRQSQQSDSNYSYNSGFGPYGGTSISASQHQRQDSQSNYEYYNNGGGLYSKDAKKELKDPSTSA
What is the function of this protein?
General role in the development of germlings including formation of the infection structures.
What are the official names of this protein?
Infection structure-specific protein 56.
Protein: EMBC_MYCBO
Sequence: MATEAAPPRIAVRLPSTSVRDAGANYRIARYVAVVAGLLGAVLAIATPLLPVNQTTAQLNWPQNGTFASVEAPLIGYVATDLNITVPCQAAAGLAGSQNTGKTVLLSTVPKQAPKAVDRGLLLQRANDDLVLVVRNVPLVTAPLSQVLGPTCQRLTFTAHADRVAAEFVGLVQGPNAEHPGAPLRGERSGYDFRPQIVGVFTDLAGPAPPGLSFSASVDTRYSSSPTPLKMAAMILGVALTGAALVALHILDTADGMRHRRFLPARWWSIGGLDTLVIAVLVWWHFVGANTSDDGYILTMARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALWAHVSTASIWMRLPTLAMALTCWWVISREVIPRLGHAVKTSRAAAWTAAGMFLAVWLPLDNGLRPEPIIALGILLTWCSVERAVATSRLLPVAIACIIGALTLFSGPTGIASIGALLVAIGPLRTILHRRSRRFGVLPLVAPILAAATVTAIPIFRDQTFAGEIQANLLKRAVGPSLKWFDEHIRYERLFMASPDGSIARRFAVLALVLALAVSVAMSLRKGRIPGTAAGPSRRIIGITIISFLAMMFTPTKWTHHFGVFAGLAGSLGALAAVAVTGAAMRSRRNRTVFAAVVVFVLALSFASVNGWWYVSNFGVPWSNSFPKWRWSLTTALLELTVLVLLLAAWFHFVANGDGRRTARPTRFRARLAGIVQSPLAIATWLLVLFEVVSLTQAMISQYPAWSVGRSNLQALAGKTCGLAEDVLVELDPNAGMLAPVTAPLADALGAGLSEAFTPNGIPADVTADPVMERPGDRSFLNDDGLITGSEPGTEGGTTAAPGINGSRARLPYNLDPARTPVLGSWRAGVQVPAMLRSGWYRLPTNEQRDRAPLLVVTAAGRFDSREVRLQWATDEQAAAGHHGGSMEFADVGAAPAWRNLRAPLSAIPSTATQVRLVADDQDLAPQHWIALTPPRIPRVRTLQNVVGAADPVFLDWLVGLAFPCQRPFGHQYGVDETPKWRILPDRFGAEANSPVMDHNGGGPLGITELLMRATTVASYLKDDWFRDWGALQRLTPYYPDAQPADLNLGTVTRSGLWSPAPLRRG
What is the function of this protein?
Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
What are the official names of this protein?
Probable arabinosyltransferase C.
What is the protein family that this protein belongs to?
Belongs to the emb family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LY6E_CHICK
Sequence: MKAFLFAVLAAVLCVERAHTLICFSCSDASSNWACLTPVKCAENEEHCVTTYVGVGIGGKSGQSISKGCSPVCPSAGINLGIAAASVYCCDSFLCNISGSSSVKASYAVLALGILVSFVYVLRARE
What are the official names of this protein?
Lymphocyte antigen 6E, Ly-6E, Stem cell antigen 2, SCA-2.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: DAPF_PSET1
Sequence: MLVNFSKMHGLGNDFVVIDNITQNVFLSRDQIIKLADRHFGIGFDQLLMVEAPYSPDLDFHYRIFNADGTEVEQCGNGARCFARFVRMKGLTNKHKITVSTKSGNLTLYIEKDGQVTVNMGHPNFEPSKIPLKATKRELTYIIRTEEHTVFSGAVSMGNPHCVLEVDDITTAQVDILGPLLENHERFPQRANIGFMQVISKEHIKLRVWERGVNETLACGTGACAAMVIGFIQNKLISTVQVDLPGGSLQIRWNGEGHPVRMTGPAEHVFDGQVAL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_PSEFS
Sequence: MTQVTVKQLADEVKTPVERLLQQMREAGLPHTAADEGVSDSEKQSLLTHLKSSHKAKVEEPRKITLQRKTTSTLRVAGSKSISVEVRKKKVFVQRSPEEIEAERKRELEERRAVENAARQKAEEEAKRRAEEEARRQPAAAQPAGTEAVAAPVAPVEAVREAAPVAAAPAPAADARKRDEPRRPDKPRADDNNRRGGGGDGERKNAPHRASVKEKAPAPRVAPRTTDEESDGFRRGGRGKAKLKKRNAHGFQSPTGPVVRDVQIGETITVGDLANQMSVKAAEIIKFMFKLGTPATINQVLDQETAQLVAEELGHKVTLVSDTALEDSLAESLKFEGETFSRAPVVTVMGHVDHGKTSLLDYIRRAKVAAGEAGGITQHIGAYHVETERGMVTFLDTPGHAAFTAMRARGAKATDIVILVVAADDGVMPQTIEAVQHAKAAGVPLVVAVNKIDKPGADLDRIRSELSVHGVTSEEWGGDTPFVSVSAKVGTGVDELLEAVLLQAEVLELKATPSAPGRGVVVESRLDKGRGPVATVLVQDGTLRQGDMVLVGSNYGRVRAMLDENGKPIKEAGPSIPVEILGLDGTPDAGDEMSVLSDEKKAREVALFRQGKFREVKLARAHAGKLENIFENMGQAEKKTLNIVLKSDVRGSLEALNGALNGLGNDEVQVRVVGGGVGGITESDANLALASNAVLFGFNVRADAGARKIVEQEGLDMRYYNVIYDIIEDVKKALTGMLGSDVRENILGVAEVRDVFRSPKFGAIAGCMVIEGTVYRNRPIRVLREDIVIFEGELESLRRFKDDASEVRAGMECGIGVKSYNDVKAGDKIEVYEKVQVARSL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPB_BIFLO
Sequence: MEQKFTTMAQEAVGDAIQSASAAGNAQVETLHVMDALLRQENGVARSLIEAAGGDPQAIGAAVRNALVALPSASGSSTSQPQASRQLTAAIAQAEKEMQQMGDEYVSTEHLLIGIAASKPNQSAEILEKNGVTAASLRKAVPGVRGGAKVTSPDAEGSYKALEKYSTDLTAAAKEGKLDPVIGRDQEIRRVIQILSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVAGDVPTTLQGKKLISLDLGSMVAGSKYRGEFEERLKSVLNEIKNADGQIITFIDEIHTIVGAGAAEGSMDAGNMLKPMLARGELRLIGATTLDEYRENIEKDPALERRFQQVFVGEPSVEDTIAILRGLKQRYEAHHKVTIGDDALVAAATLSNRYISGRQLPDKAIDLVDEAAAHLRMELDSSPEEIDELQRKVTRLEMEEMQLKKAEDPASKERLGKLQAELADTREKLSGLKARWDAEQAGHNKVGDLRAKLDDLRVQADKYTREGNLAEASKILYGEIPSIQKELAAAESADAESADASAANPADEPMVPDRVDADSVAEIVSDWTGIPVGRLMQGENEKLLHMEDYLGKRVIGQKEAIAAVSDAVRRSRAGISDPNRPTGSFLFLGPTGVGKTELAKALADFLFDDEKAMVRIDMSEYMEKASVSRLIGAAPGYVGYEQGGQLTEAVRRRPYSVVLFDEVEKANPEIFDVLLQVLDDGRLTDGQGRTVDFKNTILIMTSNLGSQFLVNEDMDADAKKKAVMDAVHMNFKPEFLNRLDDIVMFHPLTREELGGIVDIQVAGVSQRLTDRRITLDVTDSAREWLANTGYDPAYGARPLRRLVQTEVGDQLARMLLAGKVHDGDTVLVDQTGGEHLELSAWASDQIVSDNPDVSVDNVTEDK
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS27A_METM7
Sequence: MAAKKGAKTTTKKSDYYKVEGNAVERLKKACPKCGAGVFMAEHLNRFACGKCGYMEYKKNEKTESEE
What are the official names of this protein?
30S ribosomal protein S27ae.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS31 family.
Protein: TSAD_KINRD
Sequence: MIVLGVESSCDETGVGLVSEGVLLGDALASSMDAHARFGGVVPEVAARAHLEAIVPVMHEALGKAGLDLADVDAVAVTAGPGLSTAVQVGLASAKALAFALGKPLYGVHHLAGHAAVDVLEHGPLPRRCVALVVSGGHTSLLLLGDLARDPIVHLGDTIDDAAGEAFDKVARVLGLGYPGGPSIDRAARDGDPRAIAFPRALSRAQDPAYGFSFSGVKTAVARWVEARQDAGGEVPVADVAASFQEAVADVLTRKAVAACREHGVDALLLVGGVAANTRVRALAEQRCAAAGLELRVPPIRLCTDNGAMIAAVGDLLVRAGAPASGLDLGADPSAPLTGALLAGPWS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMN_MOUSE
Sequence: MAVEELQSIIKRCQILEEHDFKEEDFGLFQLAGQRCIEDGYINQLLEIIQDEKNKTIIKSMGWNLVGPVVRCLLRGREEDKREECFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQIILLLLQPLQTVIQKLPNNKAYSVGLALSTLWSQLSLLPVPHSEEQIQADDYGLCQCCKALIEFTKPFVEEVISDKENKENAKLKDELLKFCFKGLKCPLLTAQFLEQSEDVGNDPFRCFASEIIGFLSKIGHPVPQIILNHGRKKRTWDYLEFEEEEDKQLAESVASLTYLVFVQGIGIDQLPMVLSPSYLLQLNMEHIEVFLQRTEQSIYSKGLELLETSLLRLEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKKGLSMLQLFIDKLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQIDLSFKKTYNKWFAGAQLISLLDLVLSLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEDDNQTGLWTELGKIENNFLKPLHIGLNMSKAHYEAEIKNSQQNNQVASMCKGVCSVTVGGEEIPSMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKSKSTSEENVGIK
What is the function of this protein?
Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes.  Inhibits E3 ubiquitin ligase activity by binding to the RING domain of RBX1 and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34.  Inhibits RBX1-mediated neddylation of CUL1 (By similarity).  Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (PubMed:22405651).  Essential for normal development of the vasculature (PubMed:22405651).  Contributes to the regulation of RPS6KB1 phosphorylation (By similarity).
What are the official names of this protein?
Glomulin, FK506-binding protein-associated protein, FAP, FKBP-associated protein.
Protein: RNPA_BREBN
Sequence: MHRSHRLKKNEQFQAVFQRGSSAANKQFVLYSAKQEGQAAFRAGISVSKKIGNAVVRNRVKRLIREAVARMESDIPVGLDLVIIARPGVEAMTLEAIEQSLLHVMKRAKVIKQAPVHNGKRDGKRG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RSMH_MAGMM
Sequence: MSFQHTTVLLQETVAALAPQRGGCYLDGTFGGGGHSRLLLEQCAPTGRVIGLDRDADAIANGQALVAQMAGRLTLVKAPFAQVAEVLQQLEIAALDGAMLDLGVSSHQLDTAERGFSFIRSGPLDMRMDGDSTTPTAAALLNTLDADALADIFFHYGEERHARRIARMVVKVRQQHPFTTTTDLAERIAHMTPGYSRIHPATRVFQGLRIAVNEELQQLEQALSVLIGLLKPGGHLAVISFHSLEDRIVKRLFRDAAKPPEDPVLRGLPIAQAQRPKATLKLVHNKPLTPSEAEIEQNPRARSAKLRVAQKLA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHA_NAKMY
Sequence: MGKHSAAEDDASAFIPPDGGGPADPPIRRLAAISLHTSPLAQPGTGDAGGMNVYIEATARRLAARGVEVEIFTRATSSDLPPIVEMVPGVLVRHIVAGPFEGLDKEDLPGQLCSFAAGVMRAEARNAPGHYDLVHSHYWLSGQVGYLAKDRWGVPLVHSAHTLAKVKNAAMAEGDDPEPRGRIIGEEQVVVEADRLIANTAAERAELVGLYGADERLIDVVPPGVDTEVFSPGDRAAARQALGIGPDEKVIVFAGRIQPLKGPDVVVRAVHQLADRYPDQRWRLVIVGGASGAGRRPGHQLHELVDLLGSRDTIDFRPAVPAAELAVIYRAADVVAVPSYNESFGLVAIEAQASGTPVVAAAVGGLTVAVADGVSGSLVNGHDPGRWADALAAVTLDAPRRDRLSVGARQQAAQFSWDATVDGLLRSYRAARDGARVDQGRTGIARIDQIGRIEANGSPLARVAGR
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: HIS6_AKKM8
Sequence: MLAKRIIPCLDVTDGRVVKGTNFINLRDAGDPVECARAYDAQQADELVFLDITASSDGRATMADVVRRTAACCFMPLTVGGGIRSVKDMREMLLAGADKVSLNTAAINRPELINEGAVAFGSQCIVVAIDAKRQASGKWGVSTHGGRKFVGLDAVEWAVEAERRGAGEILLTSMDADGAKTGYDIELTRAVSSAVRIPVIASGGAGNLDHMVDVLVEGKADAVLAASIFHFGEYTVPEAKAYFASRGIPVRPLAE
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_CAUVC
Sequence: MNKSHHPHRGLLLMVVAPSGVGKTSLTRRLVSDHGDLHLSISATTRDPRPGEHDGRDYHFVSRDKFQGMLAEDAFLEWAEVYGNFYGSPKAPIMDALSRGESVLFDIDFQGAMKVHKQAGADSVLVYILPPSLAEMSRRLHTRSQDSEEVIHRRLSRAKDEVAAWEQFDYVILNDDFDRAYADLAHIYHAERLKRARNPWIGDLVSDLLKEEI
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7L_PONAB
Sequence: MAEQEQRKIPLVPENLLKKRKAYQALKATQAEQALLAKKEQRKGKGLRFKRLESFLHDSWRQKRDMVRLRRLEMKPHALELPDKHSLAFVVRIERIDGVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQAKVKNKTIPLTDNTVIEEHLGKFGVICLEDLIHEIAFPGKHFQEISWFLRPFHLSVARHATKNRVGFLKEMGTPGYRGERINQLIRQLN
What are the official names of this protein?
60S ribosomal protein L7-like 1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: TGT_SERP5
Sequence: MKYELDTTDGRARRGRLIFERGVVETPAFMPVGTYGTVKGMTPEEVKETGAQILLGNTFHLWLRPGQEIMKLHGDLHDFMQWHGPILTDSGGFQVFSLGAMRKIKEEGVHFRNPINGDKVFLSPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKSSMEMSLRWAQRSRQRFDELNNKNALFGIIQGGVYEDLRDVSVKGLVDIGFDGYAVGGLAVGEPKEDMHRILEHVCPQIPEDKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKHKDDTSPLDKDCDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRHYQRLMAGLREAIEQGKLELFVADFYGRIGKPVPPLNA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.