Protein: ZFHX3_MOUSE
Sequence: MEGCDSPVVSGKDNGCGIPQHRQWTELNSAHLPDKPSSMEQPTGESHGPLDSLRAPFNERLADSSTSAGPPAEPASKEVSCNECSASFSSLQTYMEHHCPGTHPPPALREESASDTSEEGEEESDVENLAGEIVYQPDGSAYIVESLSQLAQSGAACGSSSGSGAVPSLFLNSLPGVGGKQGDPSCAAPVYPQIINTSHIASSFGKWFEGSDPAFPNTSALAGLSPVLHSFRVFDVRHKSNKDYLNSDGSAKSSCVSKDVPNNVDLSKFDGFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHRMTLSEEERKLLSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQHPLVSTGNLIGPGHSFYGKFSGIRMEGEEALPAVAAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLASSPTKSSEGKDSGAAEGDKQESGGHQDCFSEKVEPAEEEEAEEEEEEEEEAEEEEEEEEEEEEEEEEASKGLFPNDLEEELEDSPSEESGPPAGGTTKKDLALSNPSISNSPLMPNVLQTLSRGPASTTSNSASNFVVFDGANRRSRLSFNSEGVRANVAEGRRLDFADESANKDSATAPEPNESTEGDDGGFVPHHQHAGSLCELGVGESPSGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHSAGAAAAAAAAAAAAANIGSSWGAPSPTKPKTKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMTQIQHNRHLGLGSLPSPAEAELYQYYLAQNMNLPNLKMDSTASDAQFMMSGFQLDPTGPMAAMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEPVEDAEGPSEASADPEELAKDQGSGSEEGQSKRAASSSQAEKELTDSPATTKRTSFPGSSETPLSSKRPKASEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPLLRCPLCQDMLNNKIHLQLHLTHLHSVAPDCVEKLIMTVTAPEMVMPSSMFLPAAAADRDGNSTLEEVGKQPEASEDPGKNILPPASMEHGGDLKPTSADPSCGREDSGFLCWKKGCNQVFKTSATLQTHFNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHLETSHLELSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLEDKQSPTGSDSGSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKRALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASGNSNGTGNSGGVSLSSSTPSPVGSSGANNTFTATNPSSAAMAPSVNALSQVPPESVVMPPLGNPISANIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVSLPVTSGALTLTGSGPGLLEDLKVQVQIPQQSHQQILQQQQQQSQLSLSQSHSALLQPSQHPEKKNKVVIKEKDKESQREREGPEGAEGNTGPQESLPDASKAKEKKDLAPGGGSEGTMLPPRIASDARGNATKALLENFGFELVIQYNENKQKAQKKNGKAEQGGESLEKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYREHYDKLYPLRPQTPEPPPPPPPPPPPPLPTAPPQPASAPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEPQKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKDEDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSTPAPSAAAANTAPSAFLQLTAETDELATFNSKAEASDEKPKQADPPSAQPNQTQEKQGQPKPEMQQQLEQLEQKTNAPQPKLPQPAAPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLPPSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDDCSSVNTAITDTTTGDEGNADNDSATGIATETKSSAPNEGLTKAAMMAMSEYEDRLSSGLVSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGASGSAGKSGDGGDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFGINQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQLMAQQELDRIKKANEVLGLAAQQQGMFDNAPLQALNLPTTYPALQGIPPVLLPGLNRPSLPGFTPANTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSSPTPAQATMAMAPQPPPQPQQPQPPVQQPPPPPAAQQIPAPQLTPQQQRKDKDGEKGKEKEKAHKGKGEPLPVPKKEKGEAPPAGTGTISAPLPAMEYAVDPAQLQALQAALTSDPTALLTSQFLPYFVPGFSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSRPLMGLSPGSLLQQYQQYQQSLQEAIQQQQQQQQQQQQQQQQQQRQLQQQQQQQQQKVQQQQQQQQQPKASQTPVPQGAASPDKDPAKESPKPEEQKNVPRELSPLLPKPPEEPEAESKSASADSLCDPFIVPKVQYKLVCRKCQAGFGDEEAARSHLKSLCCFGQSVVNLQEMVLHVPTGSGGGGGGGGGSGGGGGSYHCLACESALCGEEALSQHLESALHKHRTITRAARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPPSAAPSSSASPHASRKSWPPVGSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDYSEESDTDLSQKSDGPASPVEGPKDPSCPKDSGLTSVGTDTFRL
What is the function of this protein?
Transcriptional regulator which can act as an activator or a repressor.  Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence.  In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (By similarity).  Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (PubMed:26232227).  Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression.  Down-regulates the MUC5AC promoter in gastric cancer.  In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (By similarity).
What are the official names of this protein?
Zinc finger homeobox protein 3, AT motif-binding factor 1, AT-binding transcription factor 1, Alpha-fetoprotein enhancer-binding protein, Zinc finger homeodomain protein 3, ZFH-3.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. Expressed in nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.