Protein: MPSA_MACPH
Sequence: MPQRNEPIAVIGSACQFPGHSTTPSKLWELLREPRDLLQTIPSDRFNAESWYHADSAHHGTSNVTKSYFLAEDPKAFDSQFFNIPPKECEAIDPQQRLLMETVYDSLCAAGLSMESLRGSSTACYVGQMCDDWSGIMMRDWDSLPQYTATGISRSIMSNRVSYFFDWHGPSMTIDTACSSSLVAVHEAVQTLRSGDSNVAVACGANLILSPGMYIAESKLKMLSPDGRSRMWDEGANGYARGEGIAAVVLKTLSQALADGDHIECIVRETGFNQDGRTTGITMPSNVAQAALIRDTYKKAGLDPFNPKDRPQFFHAHGTGTPAGDPQEAEAISRAFFKDGEKADNKLYVGSIKTIIGHTEGTAGLASLIGTSLAMQHRTVPPNMHFTKLADRVAPFYTNLEVPTAAKPWPAAPAGQPLRASVNSFGFGGANAHAILESYEPEVHSAPAAGALPLFTPITFSANSEKSLQAMLASYSDFLKTNEPINVRDVAWTHQTRLSALAFRTAVAGQTAAEIVNSIDAALEKKENLGIRASGVEKPSILGVFTGQGAQWPTMGAALIKASPYARDTIAAMDRSLQELPEADRPSWSIRAELEAPKESSRLAEAALSQPLCTAVQVVLVDLIKAAGIKFKAVVGHSSGEIGAAYAAGLVSASDAIRIAYYRGVYAKLAGSKSGAKGAMMAVGTSLEDAREFCELEEFEGRLTVAASNAASSVTLSGDEDAIDQAEEIFKDESKFARKLRVDTAYHSFHMIPCSEPYKKALDGCGVEIGDVTSTTWFSSVVPGTKMSKETLGSQYWVDNMKNTVLFSQAITAAVKEAGPFDLAIEVGPHPALKGPCLNNIEDASGNAETPYTGLLSRGGDDVNAFSAALGFIWERFGASAVDFDAYDKLVSGSSEPKSLAVDLPRYPWDHDRTYWFESRVSAGYKYREEPPHPILGVKSIEGTTGPQVQWRNILTQREVSWMPGHKLQGQTVFPAAGYVSMAIEAVMTLAGENSVQLIELSDFVIGRAISFFDESAAQEVMFTLNVTKNTEEAISATFEVTSCPQGERQMSHNANGTISITLGIPSPDTLAAVPVQQFNMVDVEVDRFYKALSDMGYHYSPPFKAMSNIRRRVDAAVGEMTDVRGDHWEDNLLLHPGLLDTSFQAIFAAFSSPGDERLWSIHVPTIIKRMTFNPAVASFPPGEETVWPWQAAITSGPHQTLRADIEVFAENGEDVLFEVEGISMVPFSNATAENDCHLFSNFVYDIDGPSGELAGPNHPTDFDVKLATDSERFSFYWMRTLLETITPEEEEQTLIHYKRMLKWCRFVFDQVKNGEHPHVKPEALNDTLDVVEKLVEQYGQRADIDLIRAVGEDLPMKIRTNGNIVETMVRDGMLDAFYEEGLGLHIANNWEANMAVQLTHRYPRMNVLEIGGGTGGSTRIILPRLGQNFSSYTFTDVSAGFFEAAEERFKEFADRMIFKTLDMEKDITEQGFQEGHYDMILASNVLHVGADLDATMSNVRRLLKPGGWLINMETVTFYPCLRNGFAMAGLSGWWIGADTGRPWGPTIDIAEWDKVYKRTGFSGVDTYAPNFDSLHPFSVMAAQAVDERVQFLRQPLETEPADAKKEELVVIGGQTEEVSEIVDRVVELLTPRFSSVTRVESVDAFADGSATVPTCVLNLSELDVPVMQELMDDQPDKFEALKEIFSSARDILWVTKGSRAENPHARMIVNMARAIRKEIPSVNFQNLDVEVLDEGSADLFAATMLRHQALHRWEKELLPGSFRWSKEPEMHLENGKIYIPRLKSVKEMNDRYNSTKRQITHEVNAKDARIELVGTKDSYELREPSPLKPALDAEGKVIVKVSKSLLQSVKVPTAGYYFLCYGTTESGESVIAFSDSSESVVAVPQNWTIPQPPKVDASKALLSVAANILADLVITVAPAQGTLLAHDPDPIVAAALSKQAATKRIRVFFTTTQADKKGPNWIYIHPHSPRRLLKKTLPKGVSLFINLSGREDSKLMKEISEYLPAGCTLSDQSPFFSNTVESRPAANPELVAKYLSTGWAKAKATSFAIPGTKTVLPLKDVPGHPGKAEQLSVVDWEADAVVPVSVQPIDTGDNLFKPDRTYFMVGLSGEVGQSITQWMVRHGARYVVLTSRNPKVNSEWIETLEDEYNAVIKTMSLDVTDQSSLHACYDKISRTMPPIAGVAHGAMVLIDSLFQNMDYEDLMTVLRPKILGAMYLDELFSEDTLDFFILFSSITGTVGNTGQSNYIGANAFMEALGLQRRRRGLAASILGISSLVGIGYVERAENFDAEYFAKSGYRNISEQDLHMLFAEAIVRGRPESKENHEIITGIVPTYADKDSKAGYLQDIKFSHLALERSQARNDGDDSASVPVRIQLQTAVTKDEVVEIMQAGFVARIKKVLRIPAEDEFSLTASLVEQGVDSLVAVEVRSWFLKEVDVDMPVLKVLGGASIADLLNDALDRLAPEIVPNLGADPSSVSRPPVAPAPVPSVSRPASNAPPVLNKQLPLPSSAAELKAEREREAEAKRKREEERRAAELARKAAEEAKRAEELRKARERRESREQQKADVLKKARDALIKSEITEPMSFGQSRFWFLDQVLRDRTTFNMAISVRLEGRIRAEDMKKAVQAVVLRHEALRTRYFTTGEHGDAPMQGIIPDPSFVPFMHKRIKTEGEAQKELDAVRAHVWDMNSWAGIRVHLLSMPSDRAHFLIIGCHHIAMDGVSLNIFYADLEKAYKGKSLPALPLASQYRAFARQQRLDYAAGKMDADLAFYRAMIPEPQTVKPLPLFPFARVRDRVPLETYAEVSATARIDATLTSAIRAAARELRATTFHFYLAALQVLVFKLLEKKDPGCRDFFLGIADANRTDAKFMGTLGFFLNLLPLRCERGEDSAPFGDVVKAARAKAYAALERSRLPFDVLLERLDALPRSAAHAPLFQVFVDYRQGVQERQRYMGVKAAGEDWYTARTGYDVSLDVIENAAGDSRLEFKLQEALYDAEGARLLMQAYVHVLRQCAERPGREWGAVEVWPREVVERAVSVGRVPSPKYEWPATVGHQIDEIIKRHTASLAIKDGRGNVLTYAQMDDRVNSIAAALIENGAADGGRVGVFQNPTADWICSVVAIFRAGAVYIPLDLRNPLKRLASIVEAARPAAILAHSETWDKVEALGGTDSKAINVSALPDSHQPVANRAKTDGPAVILFTSGSTGTPKGMHMSHANLVKHMEVWTKQATLPEGATKLVLQQSAYTFDKSLEQILTPITMGGALYVVPAEQRGDPVSITDIIVSEGVTYTDATPSEYLMWFRYAGETLKKAKSWMFAVTAGEAVTESLLAEFRKLDLPVTLVNNYGPAEATLDATLEELPYRTMKPGDQISAGYPLPGYSVYIVDEDLKPVPIGCPGEVILAGVGIVGGYLNKPELTAQKFVPDVFANNGGIMYRTGDRGRLSDKGQLLYEGRIEGDTQIKLRGVRMELEDVEASIMSTANGALSRAVVSLRGEEGSEFLVAHVVFAPNFTVDQAVFINRLPTTLPLPQYMVPALFAVVDTLPLTPHLKVDRKAVKSLAIPDQAPKAPTTTANLTPTESRLAAIWQQMIPGAPAALSPDTEFFHIGGNSLLLVKLQALIRQTFGAQLRLIDVMDAASLAGMARAIDDATGGAQQQSPTTATTIDWAAEAAVPGDLATKIHLPASTASTPPKKSTDLTIVLTGATGLLGRNLLKHLAADPRVKRIYAVAVRPSPSSSAAPVSRIPLLSDKLVTKSGDLTLPLLGLSPADAAALAAEADVFVHVAANRSFWDAYASLRAANVGAVKDIVALAAARRVPVHFVSSGEVGKYSALTPPPGDGSDGYVASKWAAERFLENAAAEMAGLQVIVHRPLKPDGAEARPAPEDVLGELVWLAKGLGRRPVLEGLAGSLGVVPIVDVVEGVAQALFGAGDGLEREGELKVMRHVATMNVDIGAFAESVAADGELMELEGMDALTWTGEAKKAGWSMFMVSQEIVMAKGGEVVVSKR
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of macrophasetins, 3-decalinoyltetramic acids (DTAs) which feature a tetramate (pyrrolidine-2,4-dione) unit connected to a decalin fragment and that have potent bioactivities (PubMed:36452919).  The PKS-NRPS mpsA together with its associated enoylreductase partner mpsG incorporate one unit of acetyl-CoA, seven units of malonyl-CoA, and one unit of L-alanine to assemble the linear tetramic acid intermediate corresponding to the backbone of macrophasetins (PubMed:36452919).  Without the Diels-Alderase mpsD, the mpsA/G product can undergo the non-enzymatic intramolecular Diels-Alder (IMDA) reaction to generate both macrophasetin A and macrophasetin B (PubMed:36452919).  Catalyzed by mpsD, the linear tetramic acid intermediate is thoroughly converted to macrophasetin A via the endo-IMDA reaction in a regioselective and stereoselective manner (PubMed:36452919).  Finally, the cytochrome P450 monooxygenase mpsF catalyzes the hydroxylation at C20 to yield the end product macrophasetin C (PubMed:36452919).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase mpsA, Macrophasetins biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.