PharMolix/UniProtQA huggingface dataset:
Protein: EIF3A_PICGU
Sequence: MPPPHRNHNFRPENVLKRAEDLIAVDKREAALETLYEFITSKRIRYLQVEDLEPIALLLMELAVDLRKGKLAKDALHQYKKNVQMSENGLESVQVVVKRFVDLAEKKLNDAQAKADIKIDQDEDEDLETSQTPESILMSAVSNTDTADRTERELVTPWLRFLWEAFRAVLDILRNNSKTEVTYSTIVNQAFQFCFRFNRKAEFRRLCELLRAHIQTVTTQPKTAGTTNAIDLSDSETIQRYLDQRFSQLNISVKLELWQESFRSVDDVHTLITASKKTPKPVMMANYYENLARIFAVSDNGLFHAAAWNKFFNLYSQSPNATDDELSHYASILVLSTLSIPQRSSNSNETVVDDHRAKNAKLSSLLNLSHVPTRDSLLKSIVSRQILSFVDPCVKKLFDVLGENNFHPLTIKKEIAALFKEIEADKDYKHYIKTLTEVVSVRIFQQVSQVYETVKLDFLVSLGIFEGTEYTLSALEVENLIAIATKEGHLALTIDHESGVVTFKSSPFEDSLSDSLTSRLQISPAELVRSQLQKFAYTLSKTVDTIDPENARRLEASREAAVKRAVAGISEEQEEIANRVKVMDERKRVIDVAKRKQDEEAARLKSERLSAEQKAEQERMLAEQERRSLEKLEREKHLIREREKRKIAEEINAKGIIKIDLDNLENLDTDKLRIMQIEQLNKDKKNLEEKLRALSKKTDHTERAFRRYELQYLEKDAEAQIEQEAKNYELVKANKIAKAKKDFEEAHALKERFTRLVPDYSEFKSEINAKNKDKLKQLQAEAKAQLERAKQERIEQIKRERIEELAQRKREQIQAEQEEARRRQKEEELAKLKEEIRLQREKDAEMLKRRQNVEAEVASRKAAITPAAPAEAKPMTYAEKLKLKRQQAGRS
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit A, eIF3a, Eukaryotic translation initiation factor 3 110 kDa subunit homolog, eIF3 p110, Translation initiation factor eIF3, p110 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_DESAL
Sequence: MDKIIVEGGRTLSGEVQVSGAKNAALPILAASLLVDGWNTFYNVPELQDISTIGLLLEHLGAKVEKDGHTIKIDASGLCETEAPYDLVRRMRASVLVLGPLTARLKKARVSLPGGCAIGARPIDQHLRGLEMLGATVELSHGYVEVQAEKLRGADIYLDTPTVTGTENLMMAACLAEGVTILRNVAREPEIVALADLLNRMGGKVEGAGSPVLTITGVEALNPVEFTIIPDRIEAGTFMVAAALTEGDVLVKDAVPAHLQALISKLRLAGATVTEEGNGIRVQGKRPICSVDVKTLPHPGFPTDMQAQFMVLMTTAKGLSVIAETIFENRFIHVSELVRMGANISISQNSAVIRGVKHLSAAPVMATDLRASASLILAGLIAQGSTEIHRVYHIDRGYESIEQKFSQLGAAVRRVK
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_BURP1
Sequence: MATQIDASSEAAAATAAAQHTPMMQQYLRIKSEHPDTLVFYRMGDFYELFFEDAEKAARLLDLTLTQRGASAGTPIKMAGVPHHAVEQYLAKLVKFGESAAICEQIGDPATSKGPVERKVVRVVTPGTLTDAALLSDKSDVFLLALCVGHNKRGVASNIGLAWLNLASGALRLAELAPDQLGAALERIRPAEILAADGTIESVPAGMGAITRVPAWHFDIASGTQRLCDQLEVASLDGFGAQALTSANGAAGALLIYAAATQGQQLRHVRSLKVENESEYIGLDPSTRRNLELTETLRGTESPTLYSLLDTCCTAMGSRLLRHWLHHPPRASVAAQARHQAIGALLDAPPNAGLDSLRSALRQIADVERITGRLALLSARPRDLSSLRDTFAALPALRERVAEIASNAAALGRLEAALEPPPGCLDLLTRAIAAEPAAMVRDGGVIARGYDAELDELRDISENCGQFLIDLETRERARTGISNLRVEYNKVHGFYIEVTRGQTDKVPDDYRRRQTLKNAERYITPELKTFEDKALSAQERALARERALYDGVLQALLPHIEGCQRVASGLAELDLLAAFAERARTLDWVAPEFTDEIGIEIDQGRHPVVEAQVEQFIANDCALNPERKLLLITGPNMGGKSTFMRQTALIALMAYVGSYVPAKAARFGPIDRIFTRIGAADDLAGGRSTFMVEMTEAAAILNDATPHSLVLMDEIGRGTSTFDGLALAWAIARHLLSHNRCYTLFATHYFELTQLPVEFPQAANVHLSAVEHGHGIVFLHAVEEGPANQSYGLQVAQLAGVPAPVIRAARKHLAHLEQQSAAQATPQLDLFAAPPVVDEPECNEPPAATPHPALERLLELDPDDLKPRDALDLLYELHTLARSGPADAQR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: ALLC_DICDI
Sequence: MVYANNNIDPNAPCYVSECAELLSDKVGGVVLGCTDQWFAECVNLIKHSAPVWDAEKYVDTGKWMDGWETKRHNPDHDWCIIKLGIPGVIYGFEIDTAYFTGNYPPHASIEALCDDSDPNFNTLKESNNWEVILNKSDLGSSCKKYFECKVEKRFTHIKFRIYPDGGVARLRAYGRVVKDWTLVIPGELVDLAAIENGGLVTQVSDHFYGNKNNIIMPGRSVNMGDGWETKRRRGPGNDWLTVKLAKEGIVKRIEVDTNWFKGNFPTSCSIDAIHSSSAPDETHLQDYEWTNILPNSPLCGHRRHFFQNELVNNDKPFTHIRLNIFPDGGVSRLRINCSLPDSKNNNNNNNNNNNNNTSNSFKTSDRQQ
What is the function of this protein?
Utilization of purines as secondary nitrogen sources, when primary sources are limiting.
What are the official names of this protein?
Allantoicase, Allantoate amidinohydrolase.
What is the protein family that this protein belongs to?
Belongs to the allantoicase family.
Protein: PDXA_ECO55
Sequence: MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLIDRAAMLGLPLTLRPYSPNSPAQPQTTGTLTLLPVALRESVTAGQLAIENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLDELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_CAMFE
Sequence: MDDNKKKSLDLALKQIDKAFGKGTVLRLGDKEIEPIDSISSGSIGLDIALGIGGVPKGRIVEIYGPESSGKTTLTLHLIAESQKVGGVCAFVDAEHALDVKYAKNLGVDTDNLYISQPDFGEQALDIVETLARSGAVDLIVIDSVAALTPKSEIEGDMGDQHVGLQARLMSQALRKLTGVVHKMGTTVVFINQIRMKIGAMGYGTPETTTGGNALKFYASVRLDVRKIATLKQSDEPIGNRVKVKVVKNKVAPPFRQAEFDIMFGEGISKEGEIIDYGVKLDIIDKSGAWFSYDNSKLGQGRENSKAFLKENKAIADEITEKIRANMGDSIMSGAVDEEEMEGDE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFIH1_MOUSE
Sequence: MSIVCSAEDSFRNLILFFRPRLKMYIQVEPVLDHLIFLSAETKEQILKKINTCGNTSAAELLLSTLEQGQWPLGWTQMFVEALEHSGNPLAARYVKPTLTDLPSPSSETAHDECLHLLTLLQPTLVDKLLINDVLDTCFEKGLLTVEDRNRISAAGNSGNESGVRELLRRIVQKENWFSTFLDVLRQTGNDALFQELTGGGCPEDNTDLANSSHRDGPAANECLLPAVDESSLETEAWNVDDILPEASCTDSSVTTESDTSLAEGSVSCFDESLGHNSNMGRDSGTMGSDSDESVIQTKRVSPEPELQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASESGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKSYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNNIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEKHILNICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMASIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNDSDKSDDEASSCNDQLKGDVKKSLKLDETDEFLMNLFFDNKKMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFTKTRQSTYALSQWIMENAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVTSSGSGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKALQKKFADYQTNGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCLYSDED
What is the function of this protein?
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines.  Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length).  Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta.  Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and theiler's murine encephalomyelitis virus (TMEV).  Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus.  Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus.  Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L).  May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.
What are the official names of this protein?
Interferon-induced helicase C domain-containing protein 1, Helicase with 2 CARD domains, Helicard, Interferon induced with helicase C domain protein 1, Melanoma differentiation-associated protein 5, MDA-5, RIG-I-like receptor 2, RLR-2.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RLR subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Upon viral RNA stimulation and ISGylation, translocates from cytosol to mitochondrion. May be found in the nucleus, during apoptosis.
Protein: SYT_HAEDU
Sequence: MPIITLPDGSQRNFDNPVSVIEVAQSIGTGLAKATIAGRVNGERRDACDIIEQDSTLEIITAKDEDGLEIIRHSCAHLLGHAIKQLFPTVKMAIGPTIENGFYYDVDLDRTLTQDDLEAIEKRMLELAKTNYNVVKKPVSWQQARDTFEKRGEPYKIAILDENIERTATPALYHHEEYIDMCRGPHVPNMRFCQHFKLQKVAGAYWRGDSKNKMLQRIYGTAWADKKQLTEYLTRLEEAAKRDHRRIGKALDLYHMQEEAPGMVFWHNDGWTIFRELETFVRTKLKEYDYQEVKGPFMMDRVLWERTGHWQNYADLMFTTQSENREYAIKPMNCPGHVQIFNQGLKSYRDLPIRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIESEVTACIKMVYDIYSTFGFTNIFVKLSTRPDNRIGADDMWDRAEAGLSAALSANGLEYQIQHGEGAFYGPKIEFALRDCLGREWQCGTVQLDFALPSRLDASYVTEDNSRHTPVMIHRAILGSIERFIGIITEEYAGFFPVWLAPIQAVVMNITDSQADYVQQVVKQLSDAGLRVKADLRNEKVGFKVREHTLRRVPYMLVCGDKEITEGKVSVRTRKGEDLGTFNIEAFVEMLKAQVKTRELKLLGEA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_HALWD
Sequence: MSLAEFDADVVINAQNCIVGRVASEVAQRALGGETVAIVNVEDAVITGSEEDVMSVYETRSELGSDQGPAYPSRPDGIFKRAVRGMLPYKSDRGREALSNVRTYVGNPYDDDGEAIDGTTLDRLSNIKFLSLGEVSANLGATVTW
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: WRT8_CAEEL
Sequence: MNYLLLVSGLLSVWQPVFGSRCGESTIPFSLEILPSGHPVLGCARPTCFGWHPKGYQLPTTAKFSRLNRKLDGFLRDDSLFTYPFETDSSKIYKVQNSTCEPGFQSSKCDSKDQWVGGIEPETDAFQDVAYQCCTYAPLRESTDRNIATVSAGEIVIGGEVYQNESQYAFDYISNIEKSMDENGEVYYEVNIRRFACLDPHNADRRIDEVWSSENTIRKVNGQKPIAQQAPNVAVNAPIEAGTFDGEVVDGQTVVIEEIIAQQGFIVENETTVAPFAGPFQAQGFQPRFGAPQGFQPAFQQPPPQQFFPQNFQPVVQQPVQFPAQPVGYAPYAPAGWQLHYCFPADAEVNVYEKGVKRMDELEVGDWVQALHGKETTYSPVKYWLHRDPEQEAEFVEFLLENGESFTLTEKHLVFATDCQQNVKNLDDLNPTSTGKINIGECFFMAQPENASKFQKVQILDIQRVRKTGIYAPMTSLGHLLVNQIHTSCHSEIDHHLLQNSFFKHVLKLKNRISKYFWNEESNTEGNIGTSLNFLIEIFELIVPSKMISY
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.
What are the official names of this protein?
Warthog protein 8, Protein M89.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
[Warthog protein 8]: Secreted. Cell surface. Note=Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. SUBCELLULAR LOCATION: [Warthog protein 8 N-product]: Cell membrane; Peripheral membrane protein; Extracellular side. SUBCELLULAR LOCATION: [Warthog protein 8 C-product]: Secreted, extracellular space. Note=Also secreted in either cleaved or uncleaved form to mediate signaling to other cells.
Protein: ELD1_ARATH
Sequence: MKSTHHHRAPLISASSSSSSSSQNHSFVSRLLLLLTLLPVSLACLAFILQWRGGGLADPASASVRSSTSVPGGSDLNHEVFPGMETVSSVSPKSHQSSSDCSNLARSSSPSFPYYADWKFGVDTSLKPKICITTSTSAGLDQILPWMFYHKVLGVSTFFLFVEGKAATPSISKVLESIPGVKVIYRTKELEEKQAKSRIWNETWLSSFFYKPCNYELFVKQSLNMEMAIVMARDAGMDWILHLDTDELIYPAGAREYSLRRLLLDVPPNVDMVIFPNYESSVERDDIKDPFTEVSMFKKNYDHLPKDTYFGMYKEATRNNPNYFLTYGNGKSVARVQDHLRPNGAHRWHNYMKTPNEIKLEEAAVLHYTYSKFSDLTSRRDRCGCKPTKEDVKRCFMLDFDRSAFIIASTATDEEMLSWYREHVVWGDKDVKTKLLRKGILTRIYSPMVVIQALKESGVFSSVVSSASTNLSKKKFLSSIHKSNSSRSTASESLPSKESKSEGISARHLLEAESAIPPLSPPGMEQARFFTED
What is the function of this protein?
Involved in the coordination between cell elongation and cellulose synthesis by promoting the expression of genes involved in cell elongation and cellulose synthesis (PubMed:15010620, PubMed:10859181, PubMed:12215501, PubMed:24995569).  Acts as a regulator of plasmodesmatal permeability (PubMed:22457425).  Mediates abscisic acid (ABA) and sugar responses essential for growth (e. g.  seed germination, stomatal regulation and ABA-regulated gene expression) (PubMed:14742875).  Required for normal organogenesis by promoting cell elongation, regulating cell differentiation in vascular tissues and maintaining root meristem identity (PubMed:15010620, PubMed:10859181).  Regulates crystalline cellulose microfibrils deposition and parallel organization during the elongation phase of the cell (PubMed:12215501).  Maybe a glycosyltransferase (PubMed:22457425).  Negative factor in light inhibition of hypocotyl elongation through modulating cellulose biosynthesis (PubMed:24995569).
What are the official names of this protein?
Glycosyltransferase-like KOBITO 1, Protein ABA INSENSITIVE 8, Protein ELONGATION DEFECTIVE 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 92 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cytoplasm. Cell membrane. Note=The cell membrane subcellular localization first observed (PubMed:12215501) and the punctate pattern within the cytoplasm (PubMed:14742875) could not be confirmed (PubMed:15010620).
Protein: Y1717_BRUSU
Sequence: MAGHSQFKNIMHRKGRQDAVRSKMFSKLAREITVAAKQGLPDPAMNPRLRLAIQNAKAQSMPKDNIERAIKKAAGNDGENYDEVRYEGRGPGGVSVIVEALTDNRNRTASNVRAAFTKSGGSLGETGSVSFMFDRVGEIVYKPEAGDADKVMEAAIEAGAEDVQSGEDGHVILCAFEDIGEVSKALEAALGEAESIKTIWKPQTNTELDEEKARSVLKLLSVLEDDDDVQNVYTNFEVSDEVMEKLSA
What are the official names of this protein?
Probable transcriptional regulatory protein BR1717/BS1330_I1711.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUS6_PONPY
Sequence: MAAAMTFYRLLNRWGEAARSLRLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVNENFAIDLIAEQPVSEVETRVIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFRQHHH
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial, Complex I-13kD-A, CI-13kD-A, NADH-ubiquinone oxidoreductase 13 kDa-A subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFS6 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: PVK2_HOSCA
Sequence: GSSGLISMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, HosCa-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA_ECO5E
Sequence: MLIKLLTKVFGSRNDRTLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVLENLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGLTVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKRVNKIIPHLIRQEKEDSETFQGEGHFSVDEKSRQVNLTERGLVLIEELLVKEGIMDEGESLYSPANIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLNAKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYSQRNELLDVSDVSETINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLDLPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEELEQQRRMEAERLAQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCPCGSGKKYKQCHGRLQ
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: RSMH_STRA1
Sequence: MTNDFHHITVLLHETVDMLDIKPDGIYVDATLGGAGHSEYLLSQLGPDGHLYAFDQDQKAIDNAHIRLKKYVDTGQVTFIKDNFRNLSSNLKALGVSEINGICYDLGVSSPQLDERERGFSYKQDAPLDMRMNREQSLTAYDVVNTYSYHDLVRIFFKYGEDKFSKQIARKIEQVRAEKTISTTTELAEIIKSSKSAKELKKKGHPAKQIFQAIRIEVNDELGAADESIQQAMDLLAVDGRISVITFHSLEDRLTKQLFKEASTVEVPKGLPFIPDDLQPKMELVNRKPILPSQEELEANNRAHSAKLRVARRIR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LP14_BACIU
Sequence: MKIYGVYMDRPLSAGEEDRMMAAVSAEKREKCRRFYHKEDAHRTLIGDMLIRTAAAKAYGLDPAGISFGVQEYGKPYIPALPDMHFNISHSGRWIVCAVDSKPIGIDIEKMKPGTIDIAKRFFSPTEYSDLQAKHPDQQTDYFYHLWSMKESFIKQAGKGLSLPLDSFSVRLKDDGHVSIELPDGHEPCFIRTYDADEEYKLAVCAAHPDFCDGIEMKTYEELL
What is the function of this protein?
May activate the peptidyl carrier protein (PCP) domains of surfactin synthetase SRF1/2/3 and iturin A synthetase, by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue.  Required for the coproduction of the lipopeptide antibiotics, iturin A and surfactin.
What are the official names of this protein?
4'-phosphopantetheinyl transferase, Lipopeptide antibiotics iturin A and surfactin biosynthesis protein.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
Protein: GTAB_STAAS
Sequence: MKKIKKAIIPAAGLGTRFLPATKAMPKEMLPILDKPTIQYIVEEAARAGIEDIIIVTGRHKRAIEDHFDSQKELEMVLKEKGKSELLEKVQYSTELANIFYVRQKEQKGLGHAISSARQFIGNEPFAVLLGDDIVESEVPAVKQLIDVYEETGHSVIGVQEVPEADTHRYGIIDPLTKNGRQYEVKKFVEKPAQGTAPSNLAIMGRYVLTPEIFDYLKTQKEGAGNEIQLTDAIERMNNDNQVYAYDFEGERYDVGEKLGFVKTTIEYALKDDSMREELTRFIKELGL
What is the function of this protein?
Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP.  This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i. e.  the predominant glycolipid found in the S. aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) (By similarity).
What are the official names of this protein?
UTP--glucose-1-phosphate uridylyltransferase, Alpha-D-glucosyl-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, Uridine diphosphoglucose pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 2 family.
Protein: NANE_LACLS
Sequence: MNKEQFLEKIKGGIIVSCQALPGEPLYSENGGVMPLMAKAAEQAGAVAIRANSVRDIKEIQKAVSLPIIGIIKKDYLPQKSFITATMKEIDELVATSCEVIALDCTLRERHDGLTINQFIKKIKEKYPTQLLMADCSNFKECENAYSAGVDFVGTTLSGYTEESKKQDEPDFELLEKLVEAKIPVIAEGRIHSPEQAQYVQKIGVDGMVIGGAITRPLEIASCFVQAVESVEKL
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: P_HUMAN
Sequence: MHLEGRDGRRYPGAPAVELLQTSVPSGLAELVAGKRRLPRGAGGADPSHSCPRGAAGQSSWAPAGQEFASFLTKGRSHSSLPQMSSSRSKDSCFTENTPLLRNSLQEKGSRCIPVYHPEFITAEESWEDSSADWERRYLLSREVSGLSASASSEKGDLLDSPHIRLRLSKLRRCVQWLKVMGLFAFVVLCSILFSLYPDQGKLWQLLALSPLENYSVNLSSHVDSTLLQVDLAGALVASGPSRPGREEHIVVELTQADALGSRWRRPQQVTHNWTVYLNPRRSEHSVMSRTFEVLTRETVSISIRASLQQTQAVPLLMAHQYLRGSVETQVTIATAILAGVYALIIFEIVHRTLAAMLGSLAALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLHTFHRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCTVGMCYLLVAHVVVGWN
What is the function of this protein?
Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation (PubMed:25513726, PubMed:11310796, PubMed:15262401, PubMed:22234890).  One of the components of the mammalian pigmentary system (PubMed:15262401, PubMed:18252222, PubMed:7601462).  May serve as a key control point at which ethnic skin color variation is determined.  Major determinant of brown and/or blue eye color (PubMed:15262401, PubMed:18252222, PubMed:7601462).  Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis (By similarity).
What are the official names of this protein?
P protein, Melanocyte-specific transporter protein, Pink-eyed dilution protein homolog.
What is the protein family that this protein belongs to?
Belongs to the CitM (TC 2.A.11) transporter family.
What are the subcellular locations of this protein?
Melanosome membrane; Multi-pass membrane protein.