PharMolix/UniProtQA huggingface dataset:
Protein: PA2_BUNFA
Sequence: NLYQFKNMIEEAATGT
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).  Cytotoxic in Ehrlich ascites carcinoma model in mice and towards human cancer cell line U937 (IC(50)=610 ug/ml) (PubMed:23981271).  Acts through apoptosis, modulation of PI3K/AKT, MAPKinase pathway and cell cycle regulation (PubMed:23981271).
What are the official names of this protein?
Phospholipase A2 BF-CT1, PLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: OTC_BACCQ
Sequence: MSTVQVPKLNTKDLLTLEELTKEEIISLIEFAIYLKKNKQEPLLQGKILGLIFDKHSTRTRVSFEAGMVQLGGHGMFLSGKEMQMGRGETVSDTAKVLSQYIDGIMIRTFSHADVEELAKESSIPVINGLTDDHHPCQALADLMTIYEETNTFKGIKLAYVGDGNNVCHSLLLASAKVGMHMTVATPIGYEPNEEIVKKALAIAKETGAEIEILHNPELAVNEADFIYTDVWMSMGQEGEEEKYTLFQPYQINNELVKHAKQTYRFLHCLPAHREEEVTGEIIDGPKSIVFEQAGNRLHAQKALLVSLFKNVEELS
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GABD2_MYCTO
Sequence: MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGTAADVEAAFAEARAAQTDWAKRPVIERAAVIRRYRDLVIENREFLMDLLQAEAGKARWAAQEEIVDLIANANYYARVCVDLLKPRKAQPLLPGIGKTTVCYQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSQTPYCALACAELLYRAGLPRALYAIVPGPGSVVGTAITDNCDYLMFTGSSATGSRLAEHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSNAGQLCISIERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFSVDMGSLISEAQLKTVSGHVDDATAKGAKVIAGGKARPDIGPLFYEPTVLTNVAPEMECAANETFGPVVSIYPVADVDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSGTVNVDEGYAFAWGSLSAPMGGMGLSGVGRRHGPEGLLKYTESQTIATARVFNLDPPFGIPATVWQKSLLPIVRTVMKLPGRR
What is the function of this protein?
Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate.  Although it has succinate semialdehyde dehydrogenase activity, is likely to act physiologically on a different aldehyde(s) (By similarity).
What are the official names of this protein?
Putative succinate-semialdehyde dehydrogenase [NADP(+)] 2, SSADH 2, SSDH 2.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: Y1301_PARPJ
Sequence: MAGHSKWANIKHKKAAADAKRGKVWTRLIKEIQVAARMGGGDIDSNPRLRLAVEKAYDANMPKDNVNRAIQRGVGGVDGASYEEIRYEGYGIGGAAVIVDTMTDNRTRTVAEVRHAFSKNGGNMGTDGSVSFMFDHVGQFLFAPGTAEDKLMEAALEAGADDVVTNDDGSIEVLCPPNDFPKVKSALEAAGFKAELAEVTMKPQTEVEFTGEDAVKMQKLLDALENLDDVQEVYTNAAIADE
What are the official names of this protein?
Probable transcriptional regulatory protein Bphyt_1301.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_CLOPE
Sequence: MSKVTEITHPLILHKLAFIRDKNTGSKDFRELVSEVSMLMAYEVTRNLPMEEIEIETPVCKTKCKVLAGKKVAIVPILRAGLGMVDGMLQLIPAAKVGHIGLYRDEETLQPVEYFCKLPQDIAERDVIVVDPMLATGGSAADAITLLKKRGAKQIRLMCLISSPEGIEFVQKAHPDVDIYVACIDEKLNDHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: DNAK_CLOBA
Sequence: MGKIIGIDLGTTNSCVAVMEGGEPVVITNSEGARTTPSVVSFQADGERLVGQVAKRQSITNPDKTIISIKRHMGTSYKVDIDGKNYSPQEISAMVLQKIKADAESYLGESVTQAVITVPAYFNDSERQATKDAGKIAGLEVLRIINEPTAAALAYGLDKMDSNHKILVYDLGGGTFDVSILELGDGVFEVLSTNGDTKLGGDDFDQKVMDYIAETFKAENGIDLRQDKMALQRLKEAAEKAKIELSSSMQTNINLPFITADATGPKHIDLNLTRAKFNEITHDLVQRSIEPMKKALSDAAISIDEIEKIILVGGSTRIPAVVEAVKNFTGKDPSKGVNPDECVAVGAAVQAGVLTGEVKDVLLLDVTPLTLGIETAGGIATPLIERNTTIPTKKSQIFSTAADSQTSVEINVVQGERQMAMDNKSLGRFTLSGIAPAPRGIPQIEVTFDIDANGIVKVSALDKGTGKEANITITASTNLNDEEIDKAVKEAEKFAEEDKKRKEKVETLNNADQLIYQTEKALTELGDKVSAEDKAKVTEKLEALKAIKDGEDLEAIKKATEELTQEFYAVSSKVYAAAGGDPSQAGGFDPNAAGGAQQAPHDDNVVDADFKVDDDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CCME_POLNA
Sequence: MKARHKRLGLIVAGLAALGLGAALVLSAFQKNLVFFFTPSQVAAGEAPRNRSFRVGGMVEVGSIERQADGVTVSFLVTDTAQRLRVNYRGSLPDLFKEGKGVVAQGKLTADQLFVADEVLAKHDENYMPPEAAYALKQAGAPALAGALK
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: VPS39_MOUSE
Sequence: MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCVAVRKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIVAVLPRYVEIRTLEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPTLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLNFLIENFKALAIPYLEHIIHVWEETGSQFHNCLIQLYCEKVQSLMKDYLLSLPTGKSPVPAGEEGGELGEYRQKLLMFLEISSHYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTKMAKEYCHKHYDQNKEGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPQANLQAALQVLELHYSKLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNSADT
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways.  Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion.  The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes.  Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes.  Required for fusion of endosomes and autophagosomes with lysosomes (By similarity).
What are the official names of this protein?
Vam6/Vps39-like protein.
What is the protein family that this protein belongs to?
Belongs to the VAM6/VPS39 family.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles.
Protein: HIS5_DEHMC
Sequence: MIALVDYGGGNLKSVANAIHALGYEFTLTSDPKEILSAQAVILPGVGAAADTVAGLRAKGLDEAIKELVKRDIPLLAICVGMQVLFDSTEEGGQTKCLGILAGEVKRLPDGVKIPQMGWNQLKQRVSHPLFEGIPDGTDFYFVHSYYASPADRNIIGATTDYGVDFCSLVINKRLIATQFHPEKSGSYGLKLYQNFFKMALGDKK
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENJ_MYCTO
Sequence: MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFPRDKPCGDGLTPRAVAELHQLGLGKWLADHIRHRGLRMSGFGGEVEVDWPGPSFPSYGSAVARLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRRVVSLTLADGTEVGCRQLIVADGARSPLGRKLGRRWHRETVYGVAVRGYLSTAYSDDPWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSRRPADLALRPLISYYTDLRRDEWGFTGQPRAVSSALLPMGGAVSGVAGSNWMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDSRDLARLWPSLLADRYGRGFSVARRLALLLTFPRFLPTTGPITMRSTALMNIAVRVMSNLVTDDDRDWVARVWRGGGQLSRLVDRRPPFS
What is the function of this protein?
Catalyzes the reduction of a single double bond in the isoprenoid tail of menaquinone (MK-9) in M. tuberculosis, likely the beta-isoprene unit, forming the predominant form of menaquinone found in mycobacteria, MK-9(II-H2).
What are the official names of this protein?
Menaquinone reductase, MK reductase.
What is the protein family that this protein belongs to?
Belongs to the geranylgeranyl reductase family.
Protein: APRL5_ORYSJ
Sequence: MTRCAVVAAVAAVLLVAGAAAAGGGEEEEAPSTCARRGPGFVDALASRCPCIRIEPSPPVEVRGEAIAKELNLRHRGVTYSVLFYAAWCPFSSKFRPIFEALSTMFPQIYHFTVEESSAMPSLFSRYGVRGFPAILLVNETTMVRYWGPKDLSSLVDFYKETTGFDPIAYFDVDHQDSTGDFRPVTPGDRSLRKIAKDEPFVLLAVLFIILKVAAHFVPIVVSHLKTFLVVRVQNLNLGIRRGSSQLLERALNVLDVKRLCSKLRLSNKTRDLRKGASNARAWASSFTSVSLGESSSSRQA
What are the official names of this protein?
5'-adenylylsulfate reductase-like 5, Adenosine 5'-phosphosulfate reductase-like 5, APR-like 5, OsAPRL5.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TVP23_DROME
Sequence: MASATVRNVPLLDDDTIPFGEEDEMRDPSRAGQKYTHPYVTFFHLFFRGAAILIYMFCGWFSDSFITSFVFVVLFLSADFWTVKNISGRLLVGLRWWNYVDDDGVSHWVFESKNSESYQSRVNKNEQRIFWLGLILCPVFWGLFFLFALFGLKFKWLLLVMIAIALNAANLYGYVKCNYGANKDLNSAATDFVKTQFFKNAVDIMTRPSGAPPPTNVRPTGVV
What are the official names of this protein?
Uncharacterized Golgi apparatus membrane protein-like protein CG5021.
What is the protein family that this protein belongs to?
Belongs to the TVP23 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PYRB_SULIL
Sequence: MRLRHVVSSLDLTRDDYFRIFELADKFSNVKKLNYLSGKVVSLAFFEPSTRTAQSFHTAAIKLGADVIGFASEESTSIAKGENLADTIRMLNNYSNCIVMRHKFDGAALFASEISDIPIINAGDGKHEHPTQALIDLYTIYKVFGEIDGRTFGLLGDLKYARTVNSLLRALTRFKPKKVFLISPSQLKVRREILDGLNYPVIETENPYDVIQDIDVLYVTRIQKERFVDEVEYEKVKESYVVDLKLVNMMKKDGIILHPLPRVTEIDRKVDKTTNAKYFYQASLAVPVRMALFYEVLGERKDD
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: MCC13_ARATH
Sequence: MGYEKFTWVIKNFSSLQSKYINSDKFVIGGCKWFLKGYQNANYLSLFLMVATSKTLPCGWRRYTRFRLTVVNQLSDELSQQRETETWFDQNVVLSGNRHMISLTKLNAKKGGFLVNNEVKIVVEVDVLQVIGKLDVSEGSQEVTQPLKRIRLNDDGVSVKQSIDVNGFQVLPSQVESVKRIFERHPNMALEFRAKNQHVRTSCMNVLLSLIDTLCQSLQDISIDDLGQAEKALRYLKDSDFKVDWLERKLEEVKEKKMEEQIGKSRMQELEEELKIFKQKCSDIEAQLEKEKQKCSDIEALLEKEKAKSLAAARAPPLTLDDVV
What are the official names of this protein?
MATH domain and coiled-coil domain-containing protein At3g44790, RTM3-like protein At3g44790.
Protein: SODC_ASPOR
Sequence: MVKAVAVLRGDSKISGTVTFEQADANAPTTVSWNITGHDANAERAFHVHQFGDNTNGCTSAGPHFNPFGKEHGAPEDENRHVGDLGNFKTDAEGNAVGSKQDKLIKLIGAESVLGRTLVIHAGTDDLGRSEHPESKKTGNAGARPACGVIGIAA
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_CLOBB
Sequence: MEFESVIGLEVHAELLTNTKIYCGCTTEFGGKPNTHVCPVCLGLPGSLPQLNKRVLELGIKAGLALNCKITKVGRMDRKNYFYPDCPKNYQITQDELPICRDGYIDIELESGEVKRIGIERIHIEEDAGKLLHTKRGTLVDFNRAGVPLIEVVSKPDIRTPEEATLYLTKLRSILSSAQISDCKMEEGSLRCDGNISIRERGTEPFGIRSEIKNMNSFKALEKALNYEFDRQVEAVTNGEALSVETRRWDETNNKTIVMRSKEQANDYRYFPEGDLVTLNVSDEWIEEIRKTIPELPYQKADRFVKEYGLPKYDAHVLTLTDAMADYFDECAKLSGDPKAASNWIMGDISRLMKEESTWVEDLKFSPKELAELIEVIKDGTISSAIGKKVLEDMFAEGKSPKTIIDEKGLKQNNDEDAIRQLVNKVLDENPQVIEQYKSGRTRILGFAVGQVMKETKGQANPGIVNKLVTEEVEKR
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: MURA_CERS4
Sequence: MDSILVKGNGELRGQIPIAGAKNACLALMPATLLSDEPLTLTNAPRLSDIRTMTQLLQSLGAEVASLQGGQVLALSSHALTDHRADYDIVRKMRASILVLGPMLARDGHAVVSLPGGCAIGARPVDLHLKALEAMGAELDLRDGYIHAKAPAGGLKGARVVFPLVSVGATENALMAATLAKGTTVLENAAREPEIVDLARCLRRMGAQIEGEGSSIMTIQGVDRLGGATHPVVTDRIELGTYMLAPAICGGEVELLGGRIELVGAFCEKLDAAGISVEETERGLRVARRNGRVKAVDVMTEPFPGFPTDLQAQMMALLCTAEGTSVLEERIFENRFMHAPELIRMGARIEVHGGTATVTGVEKLRGAPVMATDLRASVSLILAGLAAEGETIVSRVYHLDRGYERVEEKLSACGAQIRRIPG
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCKGM_MOUSE
Sequence: MAAMYLPGLRLSRHGLRPWCWSPCRSIQTLHVLSGDMSQLPAGVRDFVARSAHLCQPEGIHICDGTEAENTAILALLEEQGLIRKLPKYKNCWLARTDPKDVARVESKTVIVTPSQRDTVPLLAGGARGQLGNWMSPDEFQRAVDERFPGCMQGRIMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALGDGDFIKCLHSVGQPLTGHGDPVGQWPCNPEKTLIGHVPDQREIVSFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITNPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGQLRAINPENGFFGVAPGTSAATNPNAMATIQSNTLFTNVAETSDGGVYWEGIDQPLPPGVTITSWLGKPWKPGDKEPCAHPNSRFCVPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRSESTAAAEHKGKTIMHDPFAMRPFFGYNFGRYLEHWLSMEGQKGARLPRIFHVNWFRRDEAGRFLWPGFGENARVLDWICRRLEGEDSAQETPIGLVPKEGALDLSGLSAVDTSQLFSIPKDFWEQEVRDIRGYLTEQVNQDLPKEVLAELEALEGRVQKM
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial, PEPCK-M.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYD_ACTSZ
Sequence: MMRSHYCGALNRGNIGQEVTLSGWVHRRRDLGGLIFIDMRDREGIVQVCFDPKYQEALTAAADLRNEFCIQIKGEVTARPGNQINKNMATGEVEVLAKALSVYNASDVLPLDFNQNNTEEQRLKYRYLDLRRPEMAQRLKTRAKITSFVRRFMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFLTAPEVRAIMENMIRGLWLNILGADLGKFPIMTWNEAMTRFGSDKPDLRNPLEIADVADIVKDVDFKVFADPANDANGRVSVIRVPNGASITRKQIDEYTQFVGIYGAKGLAWLKVNDVNAGLEGVQSPIAKFLSEEKIKAIFDRTSAQTGDILFFGADKWQIATDAMGALRLKLGRDLGLTRLDEWQPLWVIDFPMFECDEEGNLAAMHHPFTSPKDFSPEQLEADPTAAVANAYDMVINGYEVGGGSVRIFDPKMQQTVFRILGIDEQQQREKFGFLLDALKFGTPPHAGLAFGLDRLTMLLTGTDNIRDVIAFPKTTAAACLMTEAPSFANQQALEELAITVVTKEE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALDOB_SPAAU
Sequence: MTHQFPSLSPEQKKELSDIAQRIVAPGKGILAADESTGTMGKRFQNINVENIEENRRCFRDILFSTDASIANCVGGIIFFHETLYQKSSNGKLFPQVVKEKGIVVGIKVDKGTAPLMGTDKETTTQGLDGLSERCAQYKKDGCDFAKWRCVLKISDGCPFALAIAENANVLARYASICQMNGLVPIVEPEILPDGDHDLQRCQYATEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHSCPKKFTPQEVAMATVTALRRTVPASVPGICFLSGGQSEEEASIHLNAINQVPLHRPWKLTFSYGRALQASALAAWQGKDANKAATQQVFVTRAKINGLASKGEYKPSGSADQASQQSLYTASYVY
What are the official names of this protein?
Fructose-bisphosphate aldolase B, Liver-type aldolase.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Protein: DEFPL_PSENR
Sequence: MQFTTILSIGITVFGLLNTGAFAAPQPVPEAYAVSDPEAHPDDFAGMDANQLQKRGFGCNGPWDEDDMQCHNHCKSIKGYKGGYCAKGGFVCKCY
What is the function of this protein?
Antimicrobial peptide that potently acts against several species of Gram-positive bacteria (PubMed:16222292, PubMed:19472324).  It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130).  It does not disrupt cell membranes (PubMed:20508130).  Is especially active against numerous clinical isolates of S. pneumoniae, including all 90 different serotypes and isolates resistant to clinically used antibiotics (PubMed:16222292).  In vitro, shows considerable selectivity for bacteria over mammalian cells (PubMed:16222292).  The peptide synthesized in D-amino acids does not show antibacterial activity (PubMed:19472324).  In vitro, acts on voltage-gated potassium channels by moderately inhibiting mammalian Kv1. 3/KCNA3 (IC(50)=2. 8 uM), and moderately inhibiting others potassium channels (PubMed:25568977).
What are the official names of this protein?
Fungal defensin plectasin.
What is the protein family that this protein belongs to?
Belongs to the invertebrate defensin family. Type 2 subfamily.
What are the subcellular locations of this protein?
Secreted. Host cell membrane.
Protein: COX1_SCAPL
Sequence: FWFFGHPEVYILILPGFGMISHIVAYYAGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKWDTPLLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMG
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TXC7A_CUPSA
Sequence: DLLTTIKRVKESMKRRT
What are the official names of this protein?
Cupiennin-7a, Cu-7a, Short cationic peptide-5a, SCP-5a.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 07 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS4_LACLM
Sequence: MEIIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMEAKYLHLVDLDGAKLGQTRNLEIVRKIKDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVKYGLSRIVVGVDIREGFVSTSGWLEKTTLPYLSFLKDLEKIGVKTVIVTDISKDGTLTGPNFELYDEISKETSLDVIVSGGVKDSSDIQRAADSDFYGIIVGKAYYEGKINLEKEFNHANKKNYPLS
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_BACC3
Sequence: MEARLKELKQKALELIEEAKELKGLNDVRVAYLGKKGPITEVLRGMGKLSAEERPRMGALVNEVREAIQTRLDDKISNLEKAVIEAKLATETIDVTLPGRPVETGCHHPLTAVVEQIEDVFIGMGYEVAEGTEVEKDYYNFEALNLPKDHPARDMQDTFYITEETLLRTHTSSVQARTMENNKEKGPIKIICPGKVYRRDDDDATHSHQFMQIEGLVIDKNIRMSDLKGTLQVFVKKMFGEDREIRLRPSFFPFTEPSVEMDISCMMCHGKGCGTCKGTGWIEILGAGMVHPNVLEMAGYDSKEYQGFAFGMGAERIAMLKYGVDDIRHFYTNDVRFLQQFKRA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_CITSI
Sequence: MKNVTDSFVSLVNWPFAGSFGLNTDILATNPINLSVVLGVLIFFGKGVLSDLLDNRKLRILNSIRNSEELQRGAIERLEKARARLRKIEIEADQFRVNGYSEIEREKFNLINSTYKTLDQLENYKNETIHFEQQRAINQVRQRVFQQALQGALGTLNSCLNKELHLRTISANIGMFGAMKEITD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: GSA_PROMA
Sequence: MTNAFNTSNSQAVFHAAQELMPGGVSSPVRAFKSVNGDPIVFDRVKGAYAWDLDGNRFIDYVGSWGPAICGHSHPEVIASLQEALEKGTSFGAPCELENKLAEMVIEAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKLIKFEGCYHGHADMFLVKAGSGVATLGLPDSPGVPRSTTSNTLTAPYNDLEAVKNLFAENPDAIAGVILEPIVGNAGFIQPEPGFLEGLRELTKENGSLLVFDEVMTGFRISYGGAQGRFGVTPDLTTMGKVIGGGLPVGAYGGRKDIMSMVAPAGPMYQAGTLSGNPLAMTAGIKTLEILQQEGTYERLASITNRLINGICESAKQAGIPITGSSISGMFGFYLCEGPVRNFEEAKQTNSDYFGKLHRAMLAKGVYLAPSAFEAGFTSLAHSEEDIDSTLKAFNECFNELSQ
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_SYNP6
Sequence: MLADSSQPSSFHHVTVLQRELVEGLLPDRGGWFLDATLGGGGHSELLLSEWPNTQVIGLDRDPAAIAASQTRLQLYSDRVQFQHVNFANYQPGDRRFQGIMADLGVSSPQLDEAERGFSFRQDAPLDMRMDPTAELTAAAIVNEWDETDLANLIYQYGEERLSRRIARRIVEQRPFERTLELSEAIAGAVPRSYRYGRIHPATRTFQALRIAVNGELDALQTFLDRAPDWLAPGGRIALISFHSLEDRIIKHALRGDDRLTVITRKPLLPSEAEIESNPRSRSAKLRIAERVLPES
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.