PharMolix/UniProtQA huggingface dataset:
Protein: FRE2D_DISSA
Sequence: DLLGTLGNLPLPFI
What is the function of this protein?
Peptide with unknown biological function that may act on skin macrophages to produce a cytokine-mediated stimulation of the adaptive immune system in response to invasion by microorganisms (PubMed:23262358).  It does not show antimicrobial and hemolytic activities but stimulates production of the pro-inflammatory cytokines TNF-alpha and IL-1beta by mouse peritoneal macrophages and does not potentiate the stimulation produced by lipopolysaccharide (LPS) (PubMed:23262358).  The peptide increases IL-12 production in both unstimulated and LPS-stimulated cells, but it does not stimulate IL-6 production in a significant manner (PubMed:23262358).  Stimulates insulin release from pancreatic beta-cells in a dose-dependent manner (PubMed:30244134).  This insulinotropic activity is relatively weak compared to that of GLP-1 (PubMed:30244134).  Acts without effects on membrane depolarization or changes in calcium current (PubMed:30244134).  Insulin release is predominantly mediated by the K(ATP) channel-independent pathway (PubMed:30244134).  Like GLP-1, but in a less potent manner, this peptide stimulates beta-cell proliferation (PubMed:30244134).  In a comparable potency to that provided by GLP-1, also provides protection of cells against cytokine-induced apoptosis (PubMed:30244134).
What are the official names of this protein?
Frenatin-2D, Host-defense peptide.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Frenatin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MED6_BOVIN
Sequence: MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGVEYILLHAQEPILFIIRKQQRQSPTQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVKPKVKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQQKSGEKPVPVDQTKKEAEPLPETVKSEEKETAKNVQQTVGTKGPPEKRMRLQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 6, Mediator complex subunit 6.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARLY_PELUB
Sequence: MVKNKNNMAIWGSRIKKDASTLFQKVGNSIDIDKKLFQEDILGSIAHVEMLFRQKIISFKIKNKIIFGLNKIEKEILKNKFEYNKKYEDIHMNIEKRLFQIIGEEAGYVHTARSRNDQVITDFKMWTTSATKEINKNLDNIIKTILKISEKNIETIMPGFTHLKNAQAVSFAHYLMSYVEMFNRDKKRFTYNLESLSENPLGVAALTGTSFNIDRNFTSKKLGFKRPTNNSIDTVADRDFVLDFLYSASVCSMHISRIAEELIIWNSDGFNLITLSDKVVTGSSIMPQKKNPDLLEYLRGKTGTVYGNLFSMLTILKGLPISYFKDLQDDKEILFKSNEILNNSIAILNEVLKNLKPNKQQMLDLANSGYITATDLADYLVKNHSMPFRKAYQTTASIVNYAEKKKKKLNELNIDELKKIEPRLTIEVLKIFNVKNSVNSKKSYGGTSFDNIKKMIMKYKKT
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_HELP2
Sequence: MIKAIIGKIIGTRNDRWIKQYKKQVLTINALEPTYEKMSDVELQNAFEELKKRVRSTEKDLQEKTLLEVLPESFAITREASKRILKMRHFDVQLIGGMVLNDGKIAEMKTGEGKTLVATLAVALNALKGESVYVVTVNDYLAHRDSKEMEPLYHFLGYSVGTITASVRDDDERLEIYSKDIVYGTNNEFGFDYLRDNMKYSLEHKVQKSHAFAIVDEVDSILIDEARTPLIISGPVDRRMENYNKADEVAKSMQVEIDFTIDEKNRAILITEEGIKKAENLFGVDNLYKIENAALSHHLDQALKANYLFFIDKDYIVANNEVVIVDEFTGRLSEGRRFSEGLHQALEAKEGVSIKEESQTLADITFQNYFRMFSKLAGMTGTAQTEATEFLEIYNLEVVSIPTNLAIKRKDLNDLIYKSEKEKFDAVILKIKELHDKGQPVLVGTASIEKSETLHALLKKERIPHTVLNAKQHTKEAEIIKDAGLKGAVTIATNMAGRGVDIKLTDEIKELGGLYIIGTERHESRRIDNQLRGRSGRQGDPGTSQFYLSLEDNLLRIFGSDRIKGVMEKLGLKDGEHIESKLVTRAVENAQKKVENLHFESRKHLLEYDDVANEQRKSVYKFRDELLDASYDIGAKIAENREYALNQIFSKLKAFDHQNLSEEELLGLKNVLKEDFNAHVALEDLEKASPIEKFVAEKLKSDYENKMKVLDSEQRSRIERIVYLQILDNAWREHLYTMDNLKTGINLRGYNQKDPLVEYKKESYNLFLEFIEDIKIEAIKTFSKIQFENEQDSSDAERYLDNFSEEREHESVTYRHEETLDEDLNVAMKAFAKTPKRNEPCPCQSGKKYKDCCAKSGPKKGLFAK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: PROH3_APIME
Sequence: MGRVLLSASSLLLHIQVFTRRLGNEYIEQDRPPCGTSGHPGSIRPTEMKTMTFGLNDEERAKHPRESEVLNENGAARFQQRYTHMGQKMYTCVALTVVALVSTMHFGVEAWGGLFNRFSPEMLSNLGYGSHGDHISKSGLYQRPLSTSYGYSYDSLEEVIPCYERKCTLNEHCCPGSICMNVDGDVGHCVFELGQKQGELCRNDNDCETGLMCAEVAGSETRSCQVPITSNKLYNEECNVSGECDISRGLCCQLQRRHRQTPRKVCSYFKDPLVCIGPVATDQIKSIVQYTSGEKRITGQGNRIFKRSLKAPFA
What are the official names of this protein?
Prohormone-3.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ISDE_STAA8
Sequence: MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTSYKTLPNRYKDVPEIGQPMEPNVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFDSLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKAAKQKKHPKVLILMGVPGSYLVATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMPEEVKKMFQKEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK
What is the function of this protein?
Involved in heme (porphyrin) scavenging.  Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme.  Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF.
What are the official names of this protein?
High-affinity heme uptake system protein IsdE, Iron-regulated surface determinant protein E, Staphylococcal iron-regulated protein F.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 8 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: CINAL_DEIRA
Sequence: MLLAEIISVGTELLFGEIVDSNAAFLARELGERGVTLHRKTVLGDNLGRVSEGLALALSRADLVIVGGGLGPTDDDLTREAIAAVMQETPAEDPELLAWLRGLYEARGRVMPEVNRKQAWLIPSAEALPNPVGTAPGWFVRRQTEQGEKIIVALPGPPREMHKMWREQVLPRLPLPGRALVHTTIHTQGIGESNVAEILGELTRQANPSVATYFRKTGVDVRVAASADTEAEARALLAPVLDDVRGKLARWTWGEDGQTLAGAVGQQLAGRTLGVIEAGSAGALSLLLADEPAFHDAAVTQDHRRLITLGLTPVTLKEAGLVSEQAARELAAGAREHLASDVGLSVVVGVTGERAGQAYAALDTGTLQKTVTVNWPGDPEQVRERAAVAALGLAFRALAAGGEG
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: COX1_YARLI
Sequence: MSLKLNIQRWLFSTNAKDIAVLYFIFALFSAMIGTGLSAIIRLELANTGSPFLHGNTQAFNVVITAHAILMIFFFVMPALVGGFGNYLMPLMLGASDMAFARLNNISFWLLVPSLILILTSALVEAGAGTGWTVYFPLAGIQSHSGPAVDLAIFSLHLSGFSSLLGAINFITTFINMRTIGMKYENVPLFAWAVLFTAILLLLSLPVLAAGLTMGIFDRNFNTSFFEYAGGGDAVLYQHLFYWWNHPEVYILIIPGFGIISHAVSAIASKPVFGVQGMIYAMWSIGLLGFCVWSHHMFAVGLDSDTRAYFTSATMVIAVPTSIKIFSWLATLYGGTIRLNVTALFALGFIFLFTIGGLTGVVLANSALDIPFHDSYYVVAHFHYVLSMGAVFSIFCGWYLWSPKILGLHYNERLSHIHFWLMFIGVNVTFFPMHFLGLQGMPRRINDYPDAFIGWNQVASLGSIISIVASIVFIYVVYDQLTNGLHQGNKALDSQFKPSFMGTNLNVEGYTGPTLEWTVSTPPSLHAFNTPAVLY
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DAPA_GEODF
Sequence: MFKGSIVAIVTPFNKGVVDEKKLRELVEFQIAGGTDAIVPCGTTGESSTLDYEEHDRVIEIVVQQVNKRVPVIAGTGSNSTREAIEMTEHAKQLGADGALLVTPYYNKPTQEGLYRHYMAVAEAVALPQILYNVPGRTGVNLLPETVARLAEHKNIVAIKEATGSLQQASEVLALCGDKIDVLCGDDFITFPMMACGAKGVISVVANIMPKEVAALVDAFFAGKMEEARQWHLKLLKISNAMFIESNPVPVKTAVGLMGKASDEVRLPLAPMSDANKNKLISVMKEYKLI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAP2_CANAL
Sequence: MPEKELDYIRSTDAAGSTEKDGGIYIDAFDKQDNAPPKKGFAKFIDGFRRADAEELGIDPNLSEAEKIAIMTANSPLTRSLKNRHLQMIAIGGSIGTGLFVGSGSSLHTGGPAGLLIAYILIGTMIYCTVMSLGELAVTFPVSGAFVTYNSRFIDPSWGFAMAWNYAMQWLVVLPLELVAAAMTVKYWDAKTNSAAFVVIFYVLIVAINFFGVRGYGEAEFIFSAVKVLAVLGFIILGIVLCAGGGPQGGYIGGKNWYIEGAPFPNGAKGVITVFVNAAFAFAGTELCGLAAAETENPRKSLPKACKQVFWRITLFYVICLTLVGLLVPWNDERLLGSSSADASASPFVISIRNAGIKGLPSVMNVVIMIAVLSVGNSSVYGSSRTLAALAASNQAPKIFGYIDKQGRPLVGIIAQLLVGLLCFLAASDKQGEVFNWLLALSGLSSIFTWGSINVCLIRFRRALAAQGRDTGELVFTSQVGVIGAIWGAFLNTVVLCLQFWIAVWPLHSSPSAEAFFSAYLTVPVVIVFYVGHKLWTKNWQVYICAKDIDIDTGRRELDLDLVKQEVAEEKAYIASLPFYRRVYNAWC
What is the function of this protein?
Amino-acid permease with broad substrate specificity (PubMed:21764911, PubMed:28028545).  GAP2 is the only amino-acid permease with very broad substrate specificity, none of the other GAP permeases is able to transport such a variety of amino acids (PubMed:21764911, PubMed:28028545).  GAP2 is also able to transport thialysine, and thus probably also lysine (PubMed:21764911).  Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA (PubMed:21764911).
What are the official names of this protein?
General amino-acid permease GAP2.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Under nitrogen starvation conditions, the permease is no longer in the membrane but seems to be degraded in the vacuole (PubMed:28028545).
Protein: YJDM_SHIFL
Sequence: MSLPHCPKCNSEYTYEDNGMYICPECAYEWNDAEPAQESDELIVKDANGNLLADGDSVTIIKDLKVKGSSSMLKIGTKVKNIRLVEGDHNIDCKIDGFGPMKLKSEFVKKN
What are the official names of this protein?
Protein YjdM.
What is the protein family that this protein belongs to?
Belongs to the YjdM family.
Protein: RS17_ORITB
Sequence: MPRRVLQGQVISAKSDKTIIVSVERRFKHPMYHKTVKIAKKYAVHDPDNLYNQGDKVKIIESRPISKTKCWRVIEDKGQ
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: DID4_MACLO
Sequence: MNSGNPCCDPVTCKPRRGEHCVSGPCCRNCKFLNAGTICKRARGDDMNDYCTGISPDCPRNPWKG
What is the function of this protein?
Poor inhibitor of platelet aggregation.  The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin.  Inhibition on alpha-2b/beta-3 (ITGA2B/ITGB3) is low.
What are the official names of this protein?
Disintegrin VLO4.
What is the protein family that this protein belongs to?
Belongs to the disintegrin family. Dimeric disintegrin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL6_SYNE7
Sequence: MSRIGKRPIPIPAKVSVAIDGRLVSVKGPKGELSRELPSGVVVTQEDGNIIVSRADESRLARQRHGLSRTLVANLVEGVDSGFQKRLEIIGVGYRAQVQGTTLILNVGYSNPVQIEPPEGIQFVVENNTNVVVSGISKEVVGNTAARIRAVRPPEPYKGKGIRYAGEVVLRKAGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RL17_BRUAB
Sequence: MRHGNGYRKLNRTASHRKAMFANMAASLIEHEQIVTTLPKAKEIRPIVEKLVTLGKRGDLHARRQAISAIRDVRLVAKLFDTLAARYATRNGGYIRIMKAGFRAGDNAPLAVVEFVERDVDAKGKADRARVEAEAAAEADAA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: DAPH_LACLS
Sequence: MTQAQKLSAQEIIQFIGNAEKKTQVKVTLSGMPSFKSAGFLAENGRPNFKALANKGIQVLGDFHTHYSLKIIIGDWQAVRPLLEGLTENKDYTIEFEGRNSAVPLLDTRAINARIEPGAIIRDQVMIGDNAVIMMGAIINIGAEIGEGTMIDMGAVLGGRATVGKNSHIGAGAVLAGVIEPASAEPVRVGDNVLVGANAVVIEGVQVGSGSVVAAGAIVTQDVPENVVVAGVPARTIKEIDEKTAQKTALEDALRNL
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: YKWD_BACSU
Sequence: MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQNMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKTTEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDETLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVVKAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK
What are the official names of this protein?
Uncharacterized protein YkwD.
Protein: RRF_MYCGE
Sequence: MTKAHYIDFFKQAADKKIQWLKEELTKIRTGRPNPKIFDNLLIESYGQKMPLISLAQVTINPPREIIIKPFDPKSNTNAIYSEIQRANIGVQPVIDGEKIRVNFPQITQETRLENIKHVKKIIEQIYQELRVVRRDALQMIKKDNHNEDLENSLKAEIEKINKNYSNQLEEIQKDKEKELLTI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATC_CAMLR
Sequence: MQIDDKLLTKLEKLSALKIADDKRQELEEQLSQIVNFVEKLDELKLDDVEAMTSTTNTATPFRLDESRKSDVIDMVSKHAPNSQDGFFIVPKIIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: INK1B_DANRE
Sequence: MLCVRNSGECFRDHMRHMMRSLQDLKQIREPDDQSKCSYVTRARQKRIKQREQLSRLRISDVSDTSTYDSACCLASPLEEEEDQENHAERLAQGSPSSIKSLDFDSGYSEASWQDEGVVLRRTRNVRVSSSACVRTNRIRPKSTSDACLERWTSFEASDPTDWTTSLLTRGRNRQPLVLGDNSFADLIKNWMDLPECPDSAELKPSRKTAFLVNMRRKIAGISKGLEERRSAEAKRMSCPVGFQPPKPFFHQSHTSLHPMGTDFYQFSSVMKSGSRQPIICNDVIGYI
What is the function of this protein?
Inhibitor of the serine/threonine-protein kinase pak4/pak5.  Acts by binding pak4/pak5 in a substrate-like manner, inhibiting the protein kinase activity.
What are the official names of this protein?
PAK4-inhibitor inka2, Induced in neural crest by AP2-alpha protein 2, zinca2.
What is the protein family that this protein belongs to?
Belongs to the INKA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSN3_ARATH
Sequence: MIGAVNSVEAVITSIQGLSGSPEDLSALHDLLRGAQDSLRAEPGVNFSTLDQLDASKHSLGYLYFLEVLTCGPVSKEKAAYEIPIIARFINSCDAGQIRLASYKFVSLCKILKDHVIALGDPLRGVGPLLNAVQKLQVSSKRLTALHPDVLQLCLQAKSYKSGFSILSDDIVEIDQPRDFFLYSYYGGMICIGLKRFQKALELLYNVVTAPMHQVNAIALEAYKKYILVSLIHNGQFTNTLPKCASTAAQRSFKNYTGPYIELGNCYNDGKIGELEALVVARNAEFEEDKNLGLVKQAVSSLYKRNILRLTQKYLTLSLQDIANMVQLGNAKEAEMHVLQMIQDGQIHALINQKDGMVRFLEDPEQYKSSEMIEIMDSVIQRTIGLSKNLLAMDESLSCDPLYLGKVGRERQRYDFGDDFDTVPQKFSM
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF.  It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes.  The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.
What are the official names of this protein?
COP9 signalosome complex subunit 3, Signalosome subunit 3, Protein FUSCA 11.
What is the protein family that this protein belongs to?
Belongs to the CSN3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS20_BRUSU
Sequence: MANTPSAKKAVRKIAARTEINKSRRSRVRTFVRKLEDALLSGDKQAAEVAFKAVEPELMRAASKGVVHKNTAARKVSRLAKRVKALNA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RL13_POLAQ
Sequence: MKTFSAKSHEVVHEWFVIDATDKVLGRVASEVALRLRGKHKPEYTPHVDTGDFIVVINSSKLRVTGTKGLNKIYYRHSGYPGGISSTNFDKMQDRFPGRALEKAVKGMLPKGPLGYAMIKKLKVYGDANHPHAAQQPKALEI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: CARX_GIBF5
Sequence: MKFLQQNSFTQTSMSQPHEDVSPPLRHPYLTGNFAPIHKTTNLTPCTYSGCIPPELTGGQYVRNGGNPVSHQDLGKDAHWFDGDGMLSGVAFRKASIDGKTIPEFVNQYILTDLYLSRKTTSIASPIMPSITTLVNPLSTMFQIMFATFRTIFLVILSNLPGSQQAIKRISVANTAVLYHDGRALATCESGPPMRIQLPSLDTVGWFDGVEAEGEPEISQAGSDDSPFGGSGIFSFMKEWTTGHPKVDPVTGEMLLYHNTFMPPYVHCSVLPKSNEKAPGHRLVNQPVLGVSGARMMHDFGASRSHTIIMDLPLSLDPLNTMKGKEVVAYDPTKPSRFGVFPRHLPSSVRWFHTAPCCIFHTANTWDSQSSEGELSVNLLACRMTSSTLVYTAGNIRPPVRSRCTQARVWSDEREETACRYKEAPALESPGESTGLADYFPITAESDDYDQCRLYYYEFDLAMESRNHVKSQWALSAIPFEFPSVRPDREMQEARYIYGCSTSTSCFGVALGRADKVDLLVKMDAKTLIQRGKKMNATSITGCVDRRSVCEILQEQRKDDPINIFRLPPNHYAQEPRFVPRACSTEEDDGYLLFYVFDESQLLPSGDCPPSATSELWILDAKNMRDVVAKVRLPQRVPYGLHGTWFSSQDIESQRSVESLRSLEVVQRKKEEWVNSGGQIRKSWMVLREKLEKAVG
What is the function of this protein?
Carotenoid dioxygenase; part of the car gene cluster that mediates the biosynthesis of neurosporaxanthin, a carboxylic apocarotenoid acting as an essential protective pigments and leading to orange pigmentation (PubMed:16049681, PubMed:17293483).  CarX mediates the cleavage of beta-carotene produced by carAR into retinal, the rhodopsin's chromophore that is involved in the regulation of the carotenoid biosynthetic pathway via a negative feedback mechanism (PubMed:17293483).  It can also convert the synthetic compound beta-apo-8'-carotenal but not C35-apocarotenoids such as the acidic apocarotenoid neurosporaxanthin (C35), as well as its corresponding aldehyde beta-apo-4'-carotenal (PubMed:17293483).
What are the official names of this protein?
Carotenoid dioxygenase carX, Carotenoid biosynthesis cluster protein X.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
Protein: GUAA_STRP2
Sequence: MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHKISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGGKVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSADCPYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKKIRETVGDKRVLLGLSGGVDSSVVGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLGGKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHIVWRQPFPGPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFAKIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RL23_ACIBS
Sequence: MNNERIYQVLKGLVFSEKAQVLGDTAGVQVFKVDINATKLEIKKAVEKLFGVEVVKVNTTITKGKTKRFGRTLGRRSDVKKAYVTLKAGQDVEMADLGDTAESAAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RS19_SYNSC
Sequence: MGRSLKKGPFIADSLLRKVEKQNDNDDKSVIKTWSRASTILPMMIGHTIAVHNGRTHVPVFITEQMVGHKLGEFAPTRTFKGHIRDKKGGR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.