PharMolix/UniProtQA huggingface dataset:
Protein: LIPB_AGRFC
Sequence: MQEARKCWGCGLVAILREGCGKDFFMLTRTDIETNMFPAAGSPPVRWRISEGLVAYGQAVEEMEREVAAIAAGEADELVWLLEHPPLYTAGTSADVADLIEPDRFPVFATGRGGEYTYHGPGQRVVYVMLDLKRRRQDVRAYVAALEDVIIRTLDKMNVRGERREDRVGVWVRRPEKPLLPDGGMAEDKIAALGIRLRKWVSFHGLSINVDPDLSHFSGIVPCGISAYGVTSLVDLGLPVMIGDVDVLLREAFEEVFGPAVPETGAGG
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMJ_THISH
Sequence: MSDTRISIRYASEDLRERAEALAAELNLPLAGESAGTPLVLILDGHGLSLALTAPDAPGPIQVDFVTGRLGYRQARISLRSEPLARAVGIKDSERPSVVDATAGLGRDGFVLASLGCEVTLLEREPVIAALLADGLERAARDADLAQTIARMHLVTGNARDWLTALDEAPRPDVIYLDPMYPHRDKSALVKKEMRVFRTLVGDDQDAPETLEAALAVAKRRVVVKRPARAEPLSGRKPSHQIPGKTTRFDVYVTG
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAM_EUGGR
Sequence: MEITTNQVYIALLASLIPAFFAFKLGKSLNQ
What are the official names of this protein?
Photosystem I reaction center subunit XII, PSI-M.
What is the protein family that this protein belongs to?
Belongs to the PsaM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ARGC_DICT6
Sequence: MIRVGIVGASGYVGLELTRILLKHPEVEKLYLFSDHFEDSWIFESEKIFVSDRSSYTELYKNLDVVFFALGSGETLKFLNDNQIPERFIDMSADFRFKNPGEYERVYGIKHSMPELLEKVVYGLPEVFREKIRDAKYIANPGCYPTASLLGLFPLIKNNLTYGNAIIDAKSGISGAGRKPTDKSIYGNIAENYQAYSILNHRHQPEIENIVKEMGYLRVLFIPQLIPVFRGIFASIYVPLREDITSDELYLLFKEVYKDEYFIKILPPSCSPEIKKVRGTNWAVISAQVDKNTRNAVIFVAIDNLIKGAAGQAVQNMNIMFGYDENLGLDFLPLYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_STRR6
Sequence: MIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLKGRRQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLSISHTDQFVTASVILEENHES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AKIR2_RAT
Sequence: MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQTDPGCSSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS
What is the function of this protein?
Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity).  Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity).  Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6.  Also involved in adaptive immunity by promoting B-cell activation.  Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells.  Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors.  Also plays a role in facilitating interdigital tissue regression during limb development (By similarity).
What are the official names of this protein?
Akirin-2, Fourteen-three-three beta interactant 1, Fourteen-three-three beta interacting-protein 1.
What is the protein family that this protein belongs to?
Belongs to the akirin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Membrane. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions.
Protein: RIT1_HUMAN
Sequence: MDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFISHRFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPFFETSAAYRYYIDDVFHALVREIRRKEKEAVLAMEKKSKPKNSVWKRLKSPFRKKKDSVT
What is the function of this protein?
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.  Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.
What are the official names of this protein?
GTP-binding protein Rit1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: TLR7_MOUSE
Sequence: MVFSMWTRKRQILIFLNMLLVSRVFGFRWFPKTLPCEVKVNIPEAHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMVVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLLDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQMFKETV
What is the function of this protein?
Endosomal receptor that plays a key role in innate and adaptive immunity.  Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:21402738).  Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction.  In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:14976261) (By similarity).
What are the official names of this protein?
Toll-like receptor 7.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Endosome membrane. Endoplasmic reticulum membrane; Single- pass type I membrane protein. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Protein: SOX8_HUMAN
Sequence: MLDMSEARSQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGVAVGGARGDPAEAADERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGALKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSAKAGHSDSDSGAELGPHPGGGAVYKAEAGLGDGHHHGDHTGQTHGPPTPPTTPKTELQQAGAKPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDAFDVHEFDQYLPLGGPAPPEPGQAYGGAYFHAGASPVWAHKSAPSASASPTETGPPRPHIKTEQPSPGHYGDQPRGSPDYGSCSGQSSATPAAPAGPFAGSQGDYGDLQASSYYGAYPGYAPGLYQYPCFHSPRRPYASPLLNGLALPPAHSPTSHWDQPVYTTLTRP
What is the function of this protein?
Transcription factor that may play a role in central nervous system, limb and facial development.  May be involved in male sex determination.  Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).
What are the official names of this protein?
Transcription factor SOX-8.
What are the subcellular locations of this protein?
Nucleus.
Protein: A4_MACMU
Sequence: EVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVMSQSLRKTTREPLTRDPVKL
What is the function of this protein?
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.  Interaction between APP molecules on neighboring cells promotes synaptogenesis.  Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity).  Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity).  Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity).  Inhibits G(o)-alpha ATPase activity (By similarity).  Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity).  By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity).  May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity).  In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity).  Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV.  Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons.  Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).
What are the official names of this protein?
Amyloid-beta precursor protein, ABPP, APP, Alzheimer disease amyloid A4 protein homolog, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta (A4) precursor protein, Amyloid-beta A4 protein.
What is the protein family that this protein belongs to?
Belongs to the APP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Membrane, clathrin-coated pit. Early endosome. Cytoplasmic vesicle. Note=Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles. During maturation, the immature APP (N- glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface.
Protein: VATA_BORAP
Sequence: MNTKGKVVGVNGNLVTIEVEGSVSMNEVLFVKTGGRNLKAEVIRVRGNEVDAQVFELTKGISVGDLVEFTDKLLTVELGPGLLTQVYDGLQNPLPELAIKCGFFLERGVYLRPLNKDKKWNFKKTSKVGDSVIAGDFLGFVIEGTVHHQIMIPFYKRDSYKIVEIVNDGDYSIDEQIAVIEDDSGMRHSITMSFHWPVKIPITNYKQRLIPSEPMLTQTRIIDTFFPVAKGGTFCIPGPFGAGKTVLQQVTSRNADVDIVIIAACGERAGEVVETLKEFPELIDPKTGKSLMDRTCIICNTSSMPVAAREASVYTAITIGEYYRQMGLDILLLADSTSRWAQAMREMSGRLEEIPGEEAFPAYLESVIASFYERAGIVVLNNGDIGSVTVGGSVSPAGGNFEEPVTQATLKVVGAFHGLTRERSDARKFPAISPLESWSKYKGVIDSKKTEYVRSFLVKGNEINQMMKVVGEEGISNEDFLIYLKSELLDSCYLQQNSFDSIDAAVNSERQNYMFDIVYNILKTNFEFSDKLQARDFINELRQNLLDMNLSSFKDSKFNKLEHTLSELVNFKKVI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: METN1_LISMF
Sequence: MIELHQVSKSFNVNGKTVEAVKNVSITVEKGEIFGVVGYSGAGKSTLVRCINLLERPDAGQVVIDGKNLSTLSSKELRVARRKIGMIFQGYNLLKTATVYDNIAKPLKLEGVPKDEIETRVNKYLSIVGLEDKRNNYPSQLSGGQKQRVAIARALAHEPEILLSDEATSALDPETTEAILQLLLKINAELGITIFLITHELDVIQRICDRVAVMENGHLVEQGTVLDIFTKAKHATTKRFVGSEASFDIPQDLLEKYVATGKLVSLHFIGDEADEPALALVSRKFDVLPSILAGGIDHLKNGTLGKLLVHLKGDEVEYSKAISYLKESGVVVEEVELL
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: OADC_PSEF5
Sequence: MSRLSHQDLRRGFRELIASNSCYHTASVFDPMSARIAADLGFEVGILGGSVASLQVLAAPDFALITLSEFAEQATRIGRVAQLPVIADADHGYGNALNVMRTVVELERAGIAALTIEDTLLPAQFGRKSTDLISVAEGVGKIRAALEARVDPELAIIARTNAGILPVQEIISRTQQYERAGADAICMVGIRDFEQLEQISEHLSVPLMLVTYGNPALRDDARLAELGVKIAVDGHAAYFAAIKATYDCLREQRQIFTQASDLSATELAHTYTQPEEYIVWAKEFMSVKE
What is the function of this protein?
Catalyzes the decarboxylation of oxaloacetate into pyruvate.  Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate.
What are the official names of this protein?
Oxaloacetate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family.
Protein: YNJA_ECOLI
Sequence: MGLPPLSKIPLILRPQAWLHRRHYGEVLSPIRWWGRIPFIFYLVSMFVGWLERKRSPLDPVVRSLVSARIAQMCLCEFCVDITSMKVAERTGSSDKLLAVADWRQSPLFSDEERLALEYAEAASVTPPTVDDALRTRLAAHFDAQALTELTALIGLQNLSARFNSAMDIPAQGLCRIPEKRS
What are the official names of this protein?
Uncharacterized protein YnjA.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv2313c.
Protein: FER_ENTH1
Sequence: MGKITIVNIDDCVACGACSGTCPQSVLEVNDHVEIKNPDDCIGCGACVDACPQGVLKVE
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
Protein: DMG_SQUAC
Sequence: MGCFECCIKCLGGVPYASLLATILCFSGVALFCGCGHVALTKVERIVQLYFSNNASDHVLLTDVIQMMHYVIYGVASFSFLYGIILLAEGFYTTSAVKEIHGEFKTTVCGRCISGMSVFLTYLLGIAWLGVFGFSAVPAFIYYNMWSACQTISSPPVNLTTVIEEICVDVRQYGIIPWNASPGKACGSTLTTICNTSEFDLSYHLFIVACAGAGATVIALLIYMMATTYNFAVLKFKSREDCCTKF
What are the official names of this protein?
Proteolipid protein DM gamma.
What is the protein family that this protein belongs to?
Belongs to the myelin proteolipid protein family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DXR_DESPS
Sequence: MKKISLLGATGSIGTSVLEVVRKFSDQYRIVAMAAGRNIDLFARQIEEFSPDLVSVLDEEYAHCLQERLGGFRGKILWGNAGNEEVAAYPSASITISAIVGAAGLLPTLAAIEAGKDIGLANKETLVMAGKIVMERARRKGVALLPVDSEHSAIFQALHAGKRADLAKIILTASGGPFHGRTAAELAQVTPAQALAHPNWSMGRKVSIDSATLMNKGLEVIEAKWLFDVEPENIEVVVHPQSIVHSLVEYHDGSLIAQLGVADMCIPIAYALSYPNRLPLGHKRLSLTDCACLDFIRPDTENFPALPLAFEALRRGGVAPAALNAANEIAVAAFLDGKIRFLDIARLVTDTVDVVSPGDENKLDDILAADRESREITRQKITELF
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: GLN1B_METCA
Sequence: MTPKDVLQIIKEKEVRYVDLRFADTRGKEQHVTVPASTIDEAAFEEGKMFDGSSIAGWKGINESDMILMPDASTAVMDPFFDDPTLILRCDIVEPATMQGYERDPRSIAKRAEAYMKSTGIADTALFGPENEFFIFDDVRWGANMSGSFYKVDSEEAGWNSEKVYEDGNIGHRPGVKGGYFPVPPVDSFQDLRSAMCNTLEDMGMVVEVHHHEVATAGQCEIGVRCNTLVKKADEVLLLKYAVQNVAHAYGKTATFMPKPLVGDNGNGMHVHQSLAKDGKNLFSGDLYGGLSETALHYIGGIIKHAKALNAFCNASTNSYKRLVPGFEAPVMLAYSARNRSASIRIPYVMNPKARRIEVRFPDSTANPYLAFAAMLMAGLDGIQNKIHPGDAMDKDLYDLPPEEEKAIPQVCYSFDQALEALDKDREFLTRGGVFTDDMIDAYLDLKGQEVTRLRMSTHPVEFDMYYSL
What is the function of this protein?
Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I beta, GSI beta.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDSA_HAEIN
Sequence: MLKQRVLSAIVLIAAVLCALFLFTPFYFALALGAVAILGIWEWTQFARLKQPLIRFFVTTFLGVFIFLWLYTEGNYLDAGRVFEQHLQLLLINAVSWWGLALLLVISYPKSAKFWSKNPLLQLLFAFSTLIPFVAGVLRLRLEHYTHDPYHGLFLLLYVFILVWAADSGAYFSGRAFGKRKLAPKVSPGKSWEGVIGGLITALVLAFIFIHFSNNTLVGDRNITGFIILSVATVAISVLGDLTESMFKRESGVKDSSQLIPGHGGVLDRIDSLTAAVPFFSYFYFFVL
What are the official names of this protein?
Phosphatidate cytidylyltransferase, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LON_CAMJE
Sequence: MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPSKLENGRNFDEIYNCGVIGTIMRKVPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDFLEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFDASRICDLILNTVRIKKQVAYEFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKELGSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETALDIPFEKISKKKLDIKEVSKQLNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDGAKVILCLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELRGHRRTYIGAMPGRITQGLIEAKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATANDISNIPAPLRDRMEFIELSSYTPSEKFHIMKKYLIPDELKKHGLKSNELSIDDETIELIISDYTRESGVRNLRRKVAELCRKSAKKLLLENIKKVIINTKNLNEFLDKKVFEIEKNNGENQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGDVMKESARIAFSMIKVLIDEGKIKIPKKIIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADVAMTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVDTFSDVLEYTLV
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_MYCAP
Sequence: MSEIDYKETLNMPKTDFEMRANLTTKEPLFREKWEKDNLYARVLEKNKNNTPFVLHDGPPYANGSIHIGHALNKILKDIIVRYKSMCGFYSPYVPGWDTHGLPIELKMLTDAKINYKVISPIELRKRASEYADIQIENQISQFKSLQLLTDFKKIYKTKEPKFEAAQLKLFKKMVLDGLVYKGLKPVYWSPSSQTALAEAEVEYHDVDSPSIYVALEIIDQNGSQKVKNGDKLVIWTTTPWTLLANAAVAIGENFVYCRVEHNNQGYIVAKELANKFIEISKLDNAQISVDFNANELIGIKYKSVLNDLVCPVVIGHHVSLESGTGLVHIAPLFGEDDFQIGTANSLEMIMHVEDDGVLNDAAGKYKGIFYEKANAQIFDKLTSKSALLAKGTIRHSYPHDWRTHKPILFRGTPQWFVSIDKIRQQLLNELESINTYPEWAKKRLVNMISERKDWTISRQRTWGVPIIIFYDKDGKPVINSAIFDYVIDLVEKYGTDIWWEKEADELLPEEFRSNGYTKEMDIMDVWFDSGTTSLAVEIDEKLKPPYDLYLEGSDQYRGWFNSSLINSVAYTHKSPYKQIVSHGFVLDSKGEKMSKSKGNVVDPLKVIKKYGADILRLWVANAEYTNDVNISDEIINQNSEIYRKIRNTIKFLLGNLNGYEYDESVKRTGVHQYIYNELESIKEKVYKAYDEYNFSSVIKTINKYVVELSSFYLNITKDILYVHEFDSNERMMTLANFYDITNFLIKAIAPIIPTTAEDAYMHFYKKNKLESIHLENFDIVKPYDSNVLKEWEEFFSLKDEVNLLLENAIKSGLIKRTNEAKVTIKNPSEVIKGYDLKQLLMVGAIEFGNVSKVESFMSEKCNRCWNHFSPAQIKDNLCPLCYKIVQKVNGK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_HELPS
Sequence: MYVVLEGVDGAGKSTQVGLLKDRFKNALVTKEPGGTRMGEHLRHIALNENISELARAFLFLSDRAEHIESVIKPALKEKKLIISDRSLISGMAYSQFSSLELNLLATQSVLPDKIILLLIDKEGLKQRLSHKSLDKIENQGTEKLLTIQQKLKTHAHALKEQFGCEVLELDAQKSVWDLHRQIVAFIECVV
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: SYN_SODGM
Sequence: MSVVPVVDVLQGRMPADSEITVQGWVRTRRDSKAGISFLAVYDGSCFDPLQAVINNTLPNYQNDILRLTSGCSVSVTGRVVESLGGGQRYEIQAQAIEVLGWVDDPDTYPMAAKRHSVEYLREVAHLRPRTNLIGAVARVRHTLAQAIHRFMDEQGFFWVSTPLITASDTEGAGEMFRVSTLDLENLPRTPDGKVNYDEDFFGKEAFLTVSGQLNGESYACALSKIYTFGPTFRAENSNTSRHLAEFWMAEPEVAFATLDDAAGLAEAMLKYVFQAVLTERADDMQFFAERIDKEAINRLKQFISADFAQVDYTKAVEILQNCGQTFENPVSWGIDLSSEHERYLAEKHFKAPVVVKNYPKDIKAFYMRMNDDGKTVAAMDVLAPGIGEIIGGSQREERLDRLDQRLAEMGLNKDDYWWYRDLRRYGTVPHSGFGLGFERLIVYVTGMQNIRDVIPFPRSPRNANF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_LACDB
Sequence: MALSREETARRYGTAIFDFAKDSGKTELMYSELTELKKAVQAEPRFVQVLSNPVLDAKQKKSLLTAVEQGFSAELQEVLNFLLSYDRFDNLVDIIDYYIHLYNAANHIGTGVAKTALKPDEDQLQRLADSYAKKYGLQALHLENEVDPEIIGGVVLEVEGRVIDGSVKHRLEKIRAMLTK
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.