PharMolix/UniProtQA huggingface dataset:
Protein: SSRP_LISMO
Sequence: MPKGDGKLVAQNKKARHDYAIEETFEAGIVLQGTEIKSVRNARVNLKDSYARIDKGEIFLHNMHISPYEQGNRYNHDPLRTRKLLLHKKQISRLIGETKESGYSIVPLKMYIKDGYAKVLIGVARGKKKYDKRQDLKQKEAKRDIERAFKERQQ
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RRF_THESQ
Sequence: MVNPFIKEAKEKMKRTLEKIEDELRKMRTGKPSPAILEEIKVDYYGVPTPVNQLATISISEERTLVIKPWDKSVLSLIEKAINASDLGLNPINDGNVIRLVFPSPTTEQREKWVKKAKEIVEEGKIAIRNIRREILKKIKEDQKEGLIPEDDAKRLENEIQKLTDEFIEKLDEVFEIKKEEIMEF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_FINM2
Sequence: MSRIGLKPIEIPNGVEVKVTEDNLCTVKGPKGELVEQMPKEMIIKVEDNTITVSRPSEIKRHKSLHGLTRTLVFNMIEGVTEGYKKTLIIEGTGYRAAKQGKKLVLNLGYSHTIEKEDPEGISVEVPEQHTLIISGINKQQVGNYAAKIRDLRGPEPYKGKGIRYEDEHIRRKVGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RIHC_SALEP
Sequence: MTASLHIILDTDPGIDDAAAIAAALFAPQLDLQLITTVAGNVSVEKTTRNALQLLHFWDADVPLAQGAATPLLRPLRDAAYVHGESGMEGYDFVDHQRQPLAKPAFIAIRDVLMNAPEPMTLVAIGPLTNIALLLMHYPECACNIRRLVLMGGSAGRGNFTPNAEFNIAVDPEAAALVFRSGLEIVMCGLDVTNQAMLSPDFLNKLPALNRTGKMLHSLFNHYRSGSMRTGVRMHDLCAIAWLVRPELFTLQSCFVAVETQGEYTAGTTVVDIEGRLGQPANAQVALALDVDGFRQWVAEVFAYAP
What is the function of this protein?
Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.
What are the official names of this protein?
Non-specific ribonucleoside hydrolase RihC, Purine/pyrimidine ribonucleoside hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihC subfamily.
Protein: VPU_HV1ND
Sequence: MQPLVIIAIAALVVAIIIAIVVWTIVYIEYRRIKRQRKIDCLIDRIRERAEDSGNESEGEREELSKLVEMGHHAPWDVDDL
What is the function of this protein?
Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo.
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: RS18_DANRE
Sequence: MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLNKRAGELTEDEVERVVTIMQNPRQYKIPDWFLNRQKDIKDGKYSQVLANGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (By similarity).  Plays an essential role in early embryonic development (PubMed:12006978).
What are the official names of this protein?
40S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYW_CAUVC
Sequence: MTDQAPVTYAGPPRVLSGVQPSGALHLGNYLGALVKFTRLQHEIDTFIFVADLHAITVWQDPAALAQQTREIAAAYIASGLDPDKATIFPQSAVREHAELSWIFNCVARLGWLDRMTQFKEKSGKHKERSSVGLYTYPVLQAADILIYKATHVPVGEDQKQHLELTRDIAQKFNHDFNAPGFFPLPDPLIQGPGARVMSLRDGSAKMSKSDPSDYSRINLTDTADDIAAKVKKARTDPEPLPETIEELATRAEADNLVGIFAALAGKTKAEVLADYAGKGFGTFKPALAELAVESLAPVGERMRGLLGDPAVLDAILAKGAEKAREAAAPTLAEVKKLVGFWGA
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASPD1_BORBR
Sequence: MNTPLRVGIVGCGVLANAMAGHLARQPRPVEIVGCLVRDPGRARGALPCHGSWEALLAQRPEVVVECAGQAALAQYAQVILAAGVDLVPASVGALADDALRGALLEAAAAAGARIRIPSGAMVGIDGLAAARHVGVAEVLYRGTMPPVALQRYVSGPLPERGLAFAGSAREAVARFPKNANLTGTIALAGIGFDRTRVEMLIDPDATANVHELLARGEFGDFHARVSGLRISESSPSSRIVAGSLAQAALGSGFLALS
What is the function of this protein?
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
What are the official names of this protein?
L-aspartate dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the L-aspartate dehydrogenase family.
Protein: POL1_CPSMV
Sequence: MKFFAGQTVMDVLQHVSSPTTNLRLLSYCNLKKEEDGKMMLAIKEQRHRRLLTLSYGAMCFQFSNSVGDEGIEVDDDELMFEIFDALLRTKISNSKGMTHLYSWMRGVYLSTFKVEVQCDDYNSNLLEKDLAGEAQGLSQFVSGLADWIPSRVKTLAGYAAEGIIEAFKKHFDKLLVEYCPMAVAACSWITTVWTTIKEWVQSAMDAMSWIMAGCTELISWGMCVIAGSCALSLLEKALVAMGLISSSFDLAGIFVRSAVVGAFCLTVVNKRSRNCAELLQLVSLAVGAVSSATSSCFQSPVGQATDVSAESQSGGVEMLESLAKNLTNFCDGTLVSIGKTCNAVNSINTAAGTIKNLVGRLLSMLSNFAYKLLGLESTFLRDASVVFSENVDGWLKQISWCQDQFLAKAYINQDELMVLRSLITRGEVMQREMIMGGMKVSPTVCGLINKGCTDLAKLMAGAVMHGTSGTRKIPFVVYAHGASRVGKTMVINRLIEDFRKELELGEDCVYPRNVVDDYWSGYKRQPIVVIDDFGAVSSDPSAEAQLIPLISSAPYPLNMADLSEKGMHFDSAIVMCSSNFIECSPESKVRDEMAFRNRRHVLFTVSLDPNIPYDGDDITKNQIYEIKTWFHDSYHVEATFTSYGDLLAYCKNKWVEHNTEQEANLKQLGVKKESVAFQQFRSILDLAVFVNQDAENFKQRLETPDGRCHFVSCYDKSGILRHYTIDATGDVQEMEKVDSSLDDILLEKTNKMVLAAYKMIKYHKDTNLVIKTQLADLVDPTKYTADFQFDGVIGSPLFSSQVMPSVKALPLWQRMVLYTVGQNLGRTHSSWYEGIKDKCMLALSKAYSTEIKDWPVALKIVVGVILATVAGKAFWRFYASMADAGNGGHFVGAVASAFAGSQAVVAQSRKPNRFDVAQYRYRNIPLRKRNWAEGQMSLDQSTMLIMEKCKANFVFSNISCQIVMLPGRQFLCYKHVFASLNSPMYVDIYTANKKYKLYYKPQNRVYFETDSEIMLYKDASLEDIPASCWDLFCFDAEKSLPRGSFPAEILSCKLDRTTNQHIPEWADISARTVNQKLDVEFGEYQTIFYSYLQYDVSTKAEDCGSLIIATIDGRKKIIGIHTAGRANRSGFASYMPQVEIPVQAQAAEKFFDFLEKEQHVTEGIGKVGNLKKGVWVPLPTKTNLVETPKEWHLGTEKTKEPSILSSTDLRLGDKQYDPFVGGIQKYAEPMGILDDEVLRHVATDIVEEWFDCVDPQEDTFEEVDLQVAINGLEGMEYMERVPMATSEGFPHILTRKSGEKGKGRFVYGDGEIFDLIPGTSVHEAYLTLEETCADTVPALVGIECPKDEKLPLRKIYEKPKTRCFTVLPMEYNLVVRRKFLKFVVFIMKNRHRLSCQVGINPYGMEWSRLAMSLLEKGNNILCCDYSSFDGLLTKQVMHLMSEMINELCGGSSRLKQQRTNLLMACCSRYALCKGEVWRVECGIPSGFPLTVICNSIFNELLVRYSYIKICQQARVPATITYGFSTFVKMVTYGDDNLLSVQSAITHVFDGTKLKEFLKLNGITITDGKDKTSPVLNFRNLEDCDFLKRGFKKESDVVWVGPEEKESLWAQLHYVTTNNLEKHEAYLVNVVNVIRELYLHDPREAAELRRKAIQNVDFLKENPKDLPTMAAIKEFYNMQRQQQFVDSNDNLDSLLNPDFLFVAPHRKMHEAEMELVPKWYLRDLGKAPINVLTGEADRICVLVNASIPDHLLPEKVVNISWPYGPGRGGLPTHGWAQANLYNPNSAVVKKLRTLVNQNPDDRVDICFRHDAVPVAIATIIFLVHLGKVKGRSANEYLTKIIDSAKSLKFLPKECDIIF
What is the function of this protein?
Replicates the viral genome.
What are the official names of this protein?
RNA1 polyprotein, Genome polyprotein B, P1.
What are the subcellular locations of this protein?
[Putative helicase]: Host membrane; Single-pass membrane protein. Host cytoplasm, host perinuclear region. SUBCELLULAR LOCATION: [RNA-directed RNA polymerase]: Host endoplasmic reticulum. SUBCELLULAR LOCATION: [Protease cofactor]: Host cytoplasm, host perinuclear region.
Protein: RS18_PROM5
Sequence: MPNSIFKKQLSPIKPGDPIDYKDVELLKKFITERGKILPRRMTGLTSKQQRDLTLAVKRARIVALLPFVNPEG
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: O168_CONBU
Sequence: AEDSRGTQLHRALRKATKLSESTRCKRKGSSCRRTSYDCCTGSCRNGKCG
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).  This toxin selectively and potently inhibits depolarization-activated rat Cav2. 2/CACNA1B currents (IC(50)=89 nM), when coexpressed with alpha-2/delta-1 (CACNA2D1) and beta-3 (CACNB3) subunits.  In vivo, is lethal to fish and displays potent analgesic activity in mice pain models of hot plate and acetic acid writhing but has fewer side effects on mouse motor function and lower toxicity in goldfish.  Shows higher or similar analgesic activity in the pain models mentioned above compared to MVIIA, and lower side effects.  In addition, it blocks Cav2. 2/CACNA1B more rapidly than MVIIA and also dissociates more rapidly.
What are the official names of this protein?
Omega-conotoxin Bu8.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RLR11_PLAHL
Sequence: MHFSLVLLVFAAIVIPICADTSTTKDYDDKKSLQTSNFGTAAVANMLHVLQSSDNSKRLLRMNDKAVISDHEEERSSLVKNKQKKLSYRIKKGWENVKKPFKKSAKIIEKPLKKGSKIIIEPFKKVSKIIKKFAIKGAKIVKKPFKKSARIIKKSFKNLN
What is the function of this protein?
Secreted effector that suppresses pattern-triggered immunity (PTI) in plant host.
What are the official names of this protein?
Secreted RxLR effector protein RXLR-C11.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane. Host nucleus.
Protein: KCY_ECO81
Sequence: MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLALA
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGFS_TRYBB
Sequence: MALTQSLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGRAIASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWPGKDKFIDTWKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAPMVNQIELHPLLNQKALCEYCKSKNIAVTAWSPLGQGHLVEDARLKAIGGKYGKTAAQVMLRWEIQAGVITIPKSGNEARIKENGNIFDFELTAEDIQVIDGMNAGHRYGPDPEVFMNDF
What is the function of this protein?
Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2.  Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
What are the official names of this protein?
9,11-endoperoxide prostaglandin H2 reductase, Prostaglandin F2-alpha synthase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_CYTH3
Sequence: MIAVIQRVRKASVEIADKEHASIAAGLLVLLGITHTDEELDVEWLSAKICSLRIFSDEAGKMNRSLSEINGELLVVSQFTLFASTKKGNRPSFIEAARPEQAIPLYEQFIAACEMQLNQKIKTGIFGADMQVALINDGPVTILIDSKNKQ
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPX_STRA5
Sequence: MTTFLGNPVTFTGKQLQVGDIAKDFLLIATDLSQKSLKDFEGKKKVISVVPSIDTGICSKQTRTFNEELSELDNTVVITVSMDLPFAQKRWCSAEGLDNVILLSDFYDHSFGQEYALLMNEWHLLTRAVLILDEHNKVTYTEYVDNVNSDVDYEAAINAAKILP
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: METQ_SALTY
Sequence: MAFKFKTFAAVGALIGSLALAGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGDIDANAFQHKPYLDQQIKDRGYKLVSVGKTFVYPIAGYSKKIKSLDELKDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDGVGLLPTSLDIVENPKNLKIVELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEDKDSPYVNLIVTREDNKDAENVKKFVQAYQSDEVYEAANKVFNGGAVKGW
What is the function of this protein?
This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system.
What are the official names of this protein?
D-methionine-binding lipoprotein MetQ.
What is the protein family that this protein belongs to?
Belongs to the NlpA lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: UBC2_ASPFU
Sequence: MSTSARRRLMRDFKRMQTDPPAGVSASPVADNVMTWNAVIIGPADTPFEDGTFRLVMHFEEQYPNKPPGVKFISQMFHPNVYGTGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNTSSPANVEASNLYKDNRKEYIKRVRETVEKSWED
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1.  H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.  Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 2, E2 ubiquitin-conjugating enzyme 2, Ubiquitin carrier protein ubc2, Ubiquitin-protein ligase ubc2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PSAJ_CYCTA
Sequence: MRDIKTYLSTAPVLATLWFGSLAGLLIEINRFFPDALTFPFFSF
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: FOLT1_ARATH
Sequence: MAASWQWENATAGAVAGFATVAAMHSLDVVRTRFQVNDGRGSSLPTYKNTAHAVFTIARLEGLRGLYAGFFPAVIGSTVSWGLYFFFYGRAKQRYARGRDDEKLSPALHLASAAEAGALVCLCTNPIWLVKTRLQLQTPLHQTQPYSGLLDAFRTIVKEEGPRALYKGIVPGLVLVSHGAIQFTAYEELRKIIVDLKERRRKSESTDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARLQQRPSTNGIPRYIDSLHVIRETARYEGLRGFYRGLTANLLKNVPASSITFIVYENVLKLLKQHPTTKD
What is the function of this protein?
Mediates folate import into chloroplast.
What are the official names of this protein?
Folate transporter 1, chloroplastic, AtFOLT1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: TSTD1_HUMAN
Sequence: MAGAPTVSLPELRSLLASGRARLFDVRSREEAAAGTIPGALNIPVSELESALQMEPAAFQALYSAEKPKLEDEHLVFFCQMGKRGLQATQLARSLGYTGARNYAGAYREWLEKES
What is the function of this protein?
Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631).  Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631).  The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631).
What are the official names of this protein?
Thiosulfate:glutathione sulfurtransferase, TST.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Note=Localized around the nuclear membranes.
Protein: CYC2_CHACT
Sequence: MAKFANYLMLFLLVASLVMLEAQSSDTIKVPDLGKRLLMNRDPNGIPCAESCVWIPCTITALMGCSCKNNVCYNNEL
What is the function of this protein?
Chassatide C2A: Probably participates in a plant defense mechanism (Probable).  Has no activity against bacteria up to a concentration of 80 uM (PubMed:22467870).  Has no cytotoxic and no hemolytic activity (PubMed:22467870).
What are the official names of this protein?
Chassatide C2, Cyclotide chaC2.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: WRK49_ARATH
Sequence: MEEEGYQWARRCGNNAVEDPFVYEPPLFFLPQDQHHMHGLMPNEDFIANKFVTSTLYSGPRIQDIANALALVEPLTHPVREISKSTVPLLERSTLSKVDRYTLKVKNNSNGMCDDGYKWRKYGQKSIKNSPNPRSYYKCTNPICNAKKQVERSIDESNTYIITYEGFHFHYTYPFFLPDKTRQWPNKKTKIHKHNAQDMNKKSQTQEESKEAQLGELTNQNHPVNKAQENTPANLEEGLFFPVDQCRPQQGLLEDVVAPAMKNIPTRDSVLTAS
What is the function of this protein?
Transcription factor.  Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
What are the official names of this protein?
Probable WRKY transcription factor 49, WRKY DNA-binding protein 49.
What is the protein family that this protein belongs to?
Belongs to the WRKY group II-c family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDEA_LISM4
Sequence: MSGYFQKRMLKYPLYGLIAATIILSVITFFFSWWLSALVVVGGIILTVAMFYFEYRLNEDVQLYVSNLTYRIKRSEEEALVEMPMGILLYDEHYKIEWVNPFMSKYFDKAELIGESLEEVGPEFLDVITGNDEKGIMSIAWRDHRFDTIVKRKERILYLYDRTEYYDLNKKFQANKSVFAVIFLDNYDEWAQGMDDRRRSALNNLVTSMLTNWAREHRIYLKRISTDRFMAFLTEEMLKRLEEEKFQILDRIRERTSKQNIPLTLSIGIGYKEDDLIQLADLAQSSLDLALGRGGDQVVIKQPEGKVRFYGGKTNPMEKRTRVRARVISQALQELITQSDQVFVMGHRYPDMDVIGSSLGVMRIAEMNDRNAYVVVEPGKMSPDVKRLMNEIEEYPNVIKNIVTPQVALENITEKSLLVVVDTHKPSMVINKELLDSATNVVVVDHHRRSEEFVGSPVLVYIEPYASSTAELITELFEYQPDLEQVGKIEATALLSGIVVDTKNFTLRTGSRTFDAASYLRSLGADTILVQQFLKEDITTFTQRSRLVESLEIYHDGMAIATGHEDEEFGTVIAAQAADTMLSMEGVQASFVITLRPDKLIGISARSLGQINVQVIMEKLGGGGHLSNAATQLKDVTIAEAEKQLISAIDAYWKGET
What is the function of this protein?
Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP) (PubMed:23716572, PubMed:25965978).  Overexpression decreases export of c-di-AMP, leads to slightly increased susceptibility to the antibiotic cefuroxime and somewhat slower growth in macrophages (PubMed:23716572).  There are at least 2 PDEs for c-di-AMP in this bacteria (this one and pgpH); this may be the major PDE for intracellular growth in host macrophages (PubMed:25583510).  During host infection c-di-AMP is secreted into the host cytoplasm which leads to interferon-beta production and secretion by the host (Probable).  c-di-AMP is a second messenger that mediates growth, cell wall stability and virulence (Probable).  May monitor cellular heme or NO levels (By similarity).
What are the official names of this protein?
Cyclic-di-AMP phosphodiesterase PdeA, c-di-AMP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the GdpP/PdeA phosphodiesterase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YL432_MIMIV
Sequence: MIFYIISLKIKLIRDYYKYNACIYNNNMEQIIQNVNTIINLYEQFGGSDYIGESQTQLEHMTRAAMLAEEFGEQNDIILAAFLHDIGHLIEINNDTIKMGSLGIMNHELIARDYLIEKGFDKDIANIIGNHVKAKRYLVTKYPEYKINLSEASRQTLLYQKNTMSQEEMTEFESDPLFNKSLKLRFYDDQSKLLSKSIKPLDYYRNLMIEYLSESTNNV
What are the official names of this protein?
Uncharacterized protein L432.
Protein: WNT8B_XENLA
Sequence: MFYTGSFWFIFFILPAIPFCHSWSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDKWNCPERTLQLSSHSGLRSDLNIHSTGASPAGSGLYDTGPTSPVWSINFNRILFSRLESHFNKTFLSRLQIPFPQGHTVQSATSLSTGFLSPANRETAFVHAISYAGVMYTLTRNCSLGDFDNCGCDDSRNGQLGGQGWLWGGCSDNVGFGETISKQFVDPLETGQDARAAMNLHNNEAGRKAVKSTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGNYLKEKYHKALKVDLFHGAGNSAASRGAIAETFRSISKKEIVHLEDSPDYCLENKTLGLLGTEGRECLKRGKALSKWEKRSCRRLCGDCGLAVKERRADMVSSCNCKFHWCCAVKCEQCRKSVTKYFCVKKEKRGGGIPRKKESKLKKKL
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Plays a role in the initiation of dorsal axis development.  May activate a Nieuwkoop center-like signaling pathway.
What are the official names of this protein?
Protein Wnt-8b, XWnt-8b.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: TRMA_SALSV
Sequence: MTPEHLPTEQYEAQLAEKVARLQSMMAPFSGLVPEVFRSPVSHYRMRAEFRLWHDGDDLYHIMFDQQTKSRIRVDTFPAASQLINTLMKAMIAGVRDNHALRHKLFQIDYLTTLSNQAVVSLLYHKKLDEEWREAATALRDALRAQGLNVHLIGRATKTKIELDQDYIDERLPVAGKEMIYRQVENSFTQPNAAMNIQMLEWALEVTKDSKGDLLELYCGNGNFSLALARNFDRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKRYQCETIFVDPPRSGLDSETEKMVQAYPRILYISCNPETLCKNLETLSQTHTVSRLALFDQFPYTHHMECGVLLTAR
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.