PharMolix/UniProtQA huggingface dataset:
Protein: PYRD_MYCTU
Sequence: MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVATNTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: XANA_EMEND
Sequence: MPAITVKPLTPPAGSAIDFGAVITDVDLEHLTDGDFSTIRSALYTHLVVVLKNQHQLTPKAQYELTRRFDPSATQYGHGKTLDAKRSILHPDLKTIPHQPQVQVIGHGFIDSYEGLENITLKHPHHRTFHRDPIPQEDDYDSTRFYRWHIDAALYGLNPPIVTTLLAVKVPGGRRQTVRYDDGSGETMDVPLGTTAFASGERMFELLSEEDKEFALSSRVEYAPHPYIWMSPARSLPTGLGLHSDDLELPLSELPPIDESAIQILPMVWKNPATGKPALQIHPSAVRKIHCGDGTVIDDLKKVREIAYKLQRPAISPQYVYAHDWEEGDLVLFHNRGVLHSVVGAFGEGEVRLFRQCNLAAGEGVVPYRE
What is the function of this protein?
Alpha-ketoglutarate-dependent xanthine dioxygenase is a non-heme mononuclear Fe(2+) enzyme that decarboxylates alpha-ketoglutarate to succinate and CO(2) while hydroxylating xanthine to generate uric acid (PubMed:15948966, PubMed:17429948, PubMed:18036331).  Allows xanthine utilization as a nitrogen source (PubMed:15948966).  Whereas xanA is highly specific for xanthine, alpha-ketoadipic acid can replace alpha-ketoglutarate as a cosubstrate (PubMed:17429948).  Exhibits ferroxidase activity in the absence of substrates (PubMed:18036331).
What are the official names of this protein?
Alpha-ketoglutarate-dependent xanthine dioxygenase xanA.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: HPRK_STRZP
Sequence: MSVLVKEVIEKLRLDIVYGEPELLEKEINIADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: ASSY_BACC3
Sequence: MEKKKVVLAYSGGLDTSVAIKWLQEKNYDIIALCLDLGEGKDLAFVKEKALSVGAIKSYMIDVQEEFANEYALMAMQAHTLYEGKYPLVSALSRPLIAKKLVEIAEQEGATAVAHGCTGKGNDQVRFEVSIQALNPYLEVIAPVREWKWSREEEIAYAKENNVPIPINLDSPFSIDQNLWGRSNECGILEDPWAAPPEDAYEMTLALEDTPNKPEFVEIGFEAGVPTTLNGTAYPLSELIKTLNALAGKHGVGRIDHVENRLVGIKSREVYECPAAMTLITAHKELEDLTLVKEVAHFKPMIEQKITELIYNGLWFSPLKQALNAFLQETQKNVTGTVRVKLFKGHAIVEGRKSEYSLYDEKLATYTAQDEFNHDAAVGFISLFGLPTKVYSQVNQKKVEA
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_STAA9
Sequence: MHYPEPISKLIDSFMKLPGIGPKTAQRLAFHTLDMKEDDVVQFAKALVDVKRELTYCSVCGHITENDPCYICEDKQRDRSVICVVEDDKDVIAMEKMREYKGLYHVLHGSISPMDGIGPEDINIPSLIERLKSDEVSELILAMNPNLEGESTAMYISRLVKPIGIKVTRLAQGLSVGGDLEYADEVTLSKAIAGRTEM
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: KGUA_SHISS
Sequence: MAQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSVSHTTRQPRPGEVHGEHYFFVNHDEFKEMISRDAFLEHAEVFGNYYGTSREAIEQVLATGVDVFLDIDWQGAQQIRQKMPHARSIFILPPSKIELDRRLRGRGQDSEEVIAKRMAQAVAEMSHYAEYDYLIVNDDFDTALTDLKTIIRAERLRMSRQKQRHDALISKLLAD
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSG_PSEA6
Sequence: MQYFPIFVDTKELNCLVVGAGEVAARKVELLLKTSATITVVAPWACDTVQRLADEGQVTLHTRGYESSDLTAKQLVFVATDDSQLNIDIHHQAKAQNILVNVVDNTPLCQFITPSIVDRSPIIIAMSSGGVAPVLLRYLRQKLESVIPQKVSLLGQFSEKFRETVKARFNSVTKRRYFWEDILDGDVAEQVLQGNNSKAEQMMQDKLALDEHDSGKGEVYLVGAGPGDPDLLTFRALRLMQKADVVVYDRLVSKEILELVRRDAEKIYVGKARSLHTVPQDEINALLADLALKGNRVVRLKGGDPFIFGRGGEEIETLVEKGVSFQVVPGITAASGAASYAGIPLTHRDHAKSVVFATGHLRDNSINLNWPMLAQPEQTTVFYMGLTGLPVICEKLIQHGLPDTTEIALVQSATTTEQKVVAGNLANIQQKVAEAGIKPPALIIVGSVVSLREKLNWFGADA
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: MURC_CLAMS
Sequence: MIAPDLTMDIPTELGRVHFVGIGGSGMSGIARLFLAAGHRVTGSDSRDSDAVQALRELGAEIHVGHDAAHVGDADALVVTGALWQDNPEYVLAKERGLPILHRSQALAWLISGQRLVAVAGAHGKTTSTGMIVTALLEAGRDPSFVNGGVIGGIGVSSAPGSEELFVVEADESDGSFLLYDTAVALITNVDADHLDHYGSHEAFDDAFVRFASAASELVVISSDDPGARRVTARIEGRVVTFGEDPAADIRITDIVTDGPVAFTLTHDGVSRRAALRVPGRHNAINAAGAYAVLVGLGVDPDDAIAGLAGFSGTSRRFELHAEVRGVSVYDDYAHHPTEVRAALEAARTVVGEGRIIAVHQPHLYSRTQMMAGDFARVYEELADHTIVLDVFGAREDPIPGVTGALVSERFADASHVDYLPDWQQAADRAAEIARDGDFIVTLSCGDVYRIIPQVIGALERPAGSAQPAASSRPRE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REP_CPBDV
Sequence: MSAPLSIEQDDLLTDDLKSWLSDIDFSNDNEEAIEMEPSDIEMSSPPIDIETSPPEEADVNLDDTWATVQKNGNNKLNRFILTFFPSDMDTKWLEPETYFENSPNKFDCWTGQYEYCPDTGKLHAHIYIECNHKHRIRFNVFHREIRKYHQSVQLQLAKRASKKQRQSAINYVTADFKRAPGSLVFRWEHNKFPSDFDPKCVNKKSKSDKVSKDEQHETQRLWIESKPRHWTWDQIVHENEESKKLLFGCTAGEKYHKGRHAEDARRTINDVIIFYGAGGTGKTTEAQAWGSEDEPVQECRYYRRNPDDGAFWGGGRTCYKGQRIVHYEEFAGQEAFGRLKEVCDIGKHGPAVNVKNGGALLNHDTVIFTSNIHPAGWFHKLWESDPKQWMPFERRITQVRFYPSHRADGSLNQPDENNPPYFIDQTEEFRQFVGDYDKAKEHAELHWPLKEAPEPTAQVFVPGRSHGVTENTFFEYCKTGRAP
What is the function of this protein?
Plays an essential for the replication of viral DNA.  Presumably cleaves viral genomic dsRNA replicative form to initiate rolling circle replication.
What are the official names of this protein?
Replication-associated protein, Rep, Viral protein 3, VP3.
What are the subcellular locations of this protein?
Host nucleus.
Protein: PIN1B_THEAN
Sequence: MIRNFLNFLWNNTSLRFLIINTIIFAMDKVRCAHLLLKHTGSRNPVNRNTGMPVTRTKEEAVSEMKGYLEMLRKSDNLDQEFRRLATAKSECSSARKGGDLGFFDRNTMQKPFTEASFKLEVNEISDLVETDSGVHLIYRIA
What is the function of this protein?
Peptidyl-prolyl cis/trans isomerase (PPIase) that acts as a key virulence factor by promoting host leukocyte transformation.  Binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins.  Promotes host leukocyte transformation by binding to phosphorylated host FBXW7, disrupting dimerization and promoting FBXW7 autoubiquitination and subsequent degradation.  Degradation of host FBXW7, leads to stabilization of JUN, which promotes cell transformation.
What are the official names of this protein?
Buparvaquone-resistant peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, Rotamase Pin1.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus.
Protein: ANGT_VIBA7
Sequence: MSPLIKLAASSRLHDATHYVLCPFAGGGSGAFRHWRTLSLENEVISVMLYPGREFRIDDPTVINIGTLAEEMIQALKTCNQRIEDTIIVGHSMGAQVAYEASKKLVNQGLFLKGLIISGCQAPHIKGRRLLGECDDKTFIHNLVEIGGCDPSLAKSPEWWPIFLPALRADFTATEQYIFTSLPNDKEGLPIPTLLISGDQDREANFSEIEEWKLWCNKVVDHLVVEGGHFYITEQPQMMLECIRALSTETTA
What is the function of this protein?
Probable thioesterase.  Involved in anguibactin production, but is not essential for virulence or iron transport gene expression.
What are the official names of this protein?
Probable anguibactin biosynthesis thioesterase AngT.
What is the protein family that this protein belongs to?
Belongs to the thioesterase family.
Protein: TT39B_HUMAN
Sequence: MDAVLACRLRGRGNRVAALRPRPRPGGSAGPSPFALLCAGLSPEPRAGVGSEFPAWFLGGSSQRRNMALLGSRAELEADEDVFEDALETISISSHSDMATSSLHFASCDTQQAPRQRGASTVSSSSSTKVDLKSGLEECAVALNLFLSNKFTDALELLRPWAKESMYHALGYSTIVVLQAVLTFEQQDIQNGISAMKDALQTCQKYRKKYTVVESFSSLLSRGSLEQLSEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGLKIRTSYQIYKECLSILHEIQKNKLQQEFFYEFEGGVKLGSGAFNLMLSLLPARIIRLLEFIGFSGNRELGLLQLREGASGRSMRSALCCLTILAFHTYISLILGTGEVNVAEAERLLAPFLQQFPNGSLVLFYHARIELLKGNLEEAQEVFQKCISVQEEWKQFHHLCYWELMWINVFQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEDVVATNENVVTLFRQVDSLKQRIAGKSIPTEKFAVRKARRYSASLPAPVKLILPALEMMYVWNGFSIVSKRKDLSENLLVTVEKAEAALQSQNFNSFSVDDECLVKLLKGCCLKNLQRPLQAELCYNHVVESEKLLKYDHYLVPFTLFELASLYKSQGEIDKAIKFLETARNNYKDYSLESRLHFRIQAALHLWRKPSSD
What is the function of this protein?
Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).
What are the official names of this protein?
Tetratricopeptide repeat protein 39B, TPR repeat protein 39B.
What is the protein family that this protein belongs to?
Belongs to the TTC39 family.
Protein: RRF_RENSM
Sequence: MIEETLLEAEEKMDKAVEVAKEDFSAVRTGRANPGLFAKVMVDYYGAPTPLQQLASFAVPEARTLLITPFDRSALGDIEKALSNSEVGANPSNDGNVIRVVMPELTQERRREYVKIVRGKSEDAKISIRNIRRKAKESLDKIVKDGDAGEDEGSRAEKELDGLTKTHTENIDELLKRKEAELLEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METJ_SALPB
Sequence: MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMREMGIDPETWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL331_MYCMM
Sequence: MARNEIRPAVKLRSTAGTGYTYITRKNRRNDPDRLILSKYDPVIRKHVPFREER
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: THIM_SERP5
Sequence: MLARPDVFPGARAAACLTQFKRQSPLIHCLTNEVVQELTANVLLALGASPAMVVEPTEAAQFSRLADALLINIGTLNASRAESMLAAIEAANAAGTPWTLDPVAVGGLAYRTAFAQSLLGEKPAAIRGNASEIMALSGLQASGRGVDSADDSLAALPAARELARNSGAVVAVTGVVDYITDGQRDWAVAGGDVLMTRVVGTGCALSAVVAAFCSLPGDRLDNVATACRVMSHCGEMATRRAAGPGSFTPAFLDALYQLRPEDLQ
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: PP202_ARATH
Sequence: MLVFKSTMECSISSTIHVLGSCKTSDDVNQIHGRLIKTGIIKNSNLTTRIVLAFASSRRPYLADFARCVFHEYHVCSFSFGEVEDPFLWNAVIKSHSHGKDPRQALLLLCLMLENGVSVDKFSLSLVLKACSRLGFVKGGMQIHGFLKKTGLWSDLFLQNCLIGLYLKCGCLGLSRQMFDRMPKRDSVSYNSMIDGYVKCGLIVSARELFDLMPMEMKNLISWNSMISGYAQTSDGVDIASKLFADMPEKDLISWNSMIDGYVKHGRIEDAKGLFDVMPRRDVVTWATMIDGYAKLGFVHHAKTLFDQMPHRDVVAYNSMMAGYVQNKYHMEALEIFSDMEKESHLLPDDTTLVIVLPAIAQLGRLSKAIDMHLYIVEKQFYLGGKLGVALIDMYSKCGSIQHAMLVFEGIENKSIDHWNAMIGGLAIHGLGESAFDMLLQIERLSLKPDDITFVGVLNACSHSGLVKEGLLCFELMRRKHKIEPRLQHYGCMVDILSRSGSIELAKNLIEEMPVEPNDVIWRTFLTACSHHKEFETGELVAKHLILQAGYNPSSYVLLSNMYASFGMWKDVRRVRTMMKERKIEKIPGCSWIELDGRVHEFFVDSIEVSSTL
What is the function of this protein?
Plays a major role in chloroplast RNA editing.  Acts as a site-recognition transacting factor to recruit C-deaminase (PubMed:15662426, PubMed:17015439).  Involved in single RNA editing events.  Required for the edition of the site 1 of ndhD (ndhD-1 site corresponding to cytidine-2), which is a plastid-encoded subunit of the NADH-plastoquinone oxidoreductase.  The interaction with DYW1 is required for its function in editing the ndhD-1 site (PubMed:23001034).
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g45350, chloroplastic, Protein CHLORORESPIRATORY REDUCTION 4.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: OGG1_THENN
Sequence: MEELLKELERIREEAKPLVEQRFEEFKRLGEEGTEEDLFCELSFCVLTANWSAEGGIRAQKEIGKGFVHLPLEELAEKLREVGHRYPQKRAEFIVENRKLLGKLKNLVKGDPFQSREFLVRNAKGIGWKEASHFLRNTGVEDLAILDKHVLRLMKRHGLIQEIPKGWSKKRYLYVEEILRKVAEAFGESPGKFDLYLWYLVKGKVDK
What is the function of this protein?
Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA.  Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).
What are the official names of this protein?
8-oxoguanine DNA glycosylase/AP lyase.
What is the protein family that this protein belongs to?
Belongs to the type-2 OGG1 family.
Protein: NEO1_RAT
Sequence: AAAKNGSPPQSAGASVRTFTPLYFLVEPVDTLSVRGSSVILNCSAYSEPSPNIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGFYQCVATVDNLGTIVSRTAKLAVAGLPRFTSQPEPSSIYVGNSGILNCEVNADLVPFVRWEQNRQPLLLDDRIVKLPSGTLVISNATEGDEGLYRCIVESGGPPKFSDEAELKVLQESEEMLDLVFLMRPSSMIKVIGQSAVLPCVASGLPAPVIRWMKNEDVLDTESSGRLALLAGGSLEISDVTEDDAGTYFCVADNGNKTIEAQAELTVQVPPEFLKQPANIYARESMDIVFECEVTGKPAPTVKWVKNGDVVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGVARERVENTSQPGEMQVTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNIRAYATSPTSITVTWETPLSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVRTLSDVPSAAPQNLSLEVRNSKSIVIHWQPPSSATQNGQITGYKIRYRKASRKSDVTETVVTGTQLSQLIEGLDRGTEYNFRVAALTVNGTGPATDWLSAETFESDLDESRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGATFELVPTSPPKDVTVVSKEGKPRTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQALGSAGKGGRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSIGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNCKDVKPPDLWIHHERLELKPIDKSPDPNPVMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQQSVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPIYDPALPSTPLLSQQALNHHLHSVKTASIGTLGRSRPPMPVVVPSAPEVQEATRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA
What is the function of this protein?
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis.  Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families.  Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response (By similarity).
What are the official names of this protein?
Neogenin.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. DCC family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: MARH7_PONAB
Sequence: MESKPSRIPRGISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWRHSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSYSQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRSSLRSNFSSRESESSRSNTQPGFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLSSENSYVSPRILTASQSRSNVPSTSEVPDNRASEASQGFRFLRRRWGLSSLSHNHSSESDSENFNQESESRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSRSHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGIAGILPGSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLLLEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEAVTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIAYFI
What is the function of this protein?
E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity).  May be involved in T-cell proliferation by regulating LIF secretion (By similarity).  May play a role in lysosome homeostasis (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase MARCHF7, Membrane-associated RING finger protein 7, Membrane-associated RING-CH protein VII, MARCH-VII, RING-type E3 ubiquitin transferase MARCHF7.
Protein: TF3B_YEAST
Sequence: MPVCKNCHGTEFERDLSNANNDLVCKACGVVSEDNPIVSEVTFGETSAGAAVVQGSFIGAGQSHAAFGGSSALESREATLNNARRKLRAVSYALHIPEYITDAAFQWYKLALANNFVQGRRSQNVIASCLYVACRKEKTHHMLIDFSSRLQVSVYSIGATFLKMVKKLHITELPLADPSLFIQHFAEKLDLADKKIKVVKDAVKLAQRMSKDWMFEGRRPAGIAGACILLACRMNNLRRTHTEIVAVSHVAEETLQQRLNEFKNTKAAKLSVQKFRENDVEDGEARPPSFVKNRKKERKIKDSLDKEEMFQTSEEALNKNPILTQVLGEQELSSKEVLFYLKQFSERRARVVERIKATNGIDGENIYHEGSENETRKRKLSEVSIQNEHVEGEDKETEGTEEKVKKVKTKTSEEKKENESGHFQDAIDGYSLETDPYCPRNLHLLPTTDTYLSKVSDDPDNLEDVDDEELNAHLLNEEASKLKERIWIGLNADFLLEQESKRLKQEADIATGNTSVKKKRTRRRNNTRSDEPTKTVDAAAAIGLMSDLQDKSGLHAALKAAEESGDFTTADSVKNMLQKASFSKKINYDAIDGLFR
What is the function of this protein?
General activator of RNA polymerase III transcription.  Interacts with TBP.  Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC.
What are the official names of this protein?
Transcription factor IIIB 70 kDa subunit, TFIIIB, B-related factor 1, BRF-1.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UTP8_YEAST
Sequence: MPSLSQPFRLATLPKIASLSNFSLQADYVQVADGTFNESTNNITLGISGSSISQYIINPTPKLTFDYPIPSTNIITACNAEKGQANIDGNIEASTDDEANNEKTINTQKKRNVEIWAFGLMVNKGNYTLNVITKALEDTTDTSNDHLSESDIDNKAYTGSDEFLSQYKIKAKAKVMSIKIDTKNSLVIAILQNGLIEIFDFKLTLLHSFDISYDNLKYAKWFTENGTEYVFVLCPLQDDKVCYKLLELTDCGSGESSPIKELSSTIIEGFSFENSKLCYQFGKLYKLNQGKIYIYSLPHCQLQQVIEFPMVDKLSPGDDLISFQPVSVNRVLLTVNNVIYLLDLLHCSTLSQRELTHVKTFQLLKSAVINSEKSHNSKTIAIGISTKNGPNPTSSLEIINIDVGTNTLKDSLGKSFQVGNNDSSVILKPLFDDKDINDKRVKCNDVSGDSSVPVLHCNEVIEKLSALQDNDITSFDDIFFKELKIKEEHYTEKDRYISDPGFLNKVLDLIFGKFSGNDYPKTLTFLLTHPLFPLSRTRNLLSLLRDQPRLFKQAIVTCPNLPLNELLEELFSIRNRELLLDISFRILQDFTRDSIKQEMKKLSKLDVQNFIEFITSGGEDSSPECFNPSQSTQLFQLLSLVLDSIGLFSLEGALLENLTLYIDKQVEIAERNTELWNLIDTKGFQHGFASSTFDNGTSQKRALPTYTMEYLDI
What is the function of this protein?
Involved in nucleolar processing of pre-18S ribosomal RNA.  Also has a role in nuclear tRNA export.  It acts between the steps of tRNA maturation/aminoacylation and its subsequent translocation out of the nucleus.  Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 8, U3 snoRNA-associated protein 8, U three protein 8, U3 protein 8 required for transcription, t-UTP8.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Associated with ribosomal chromatin, even in the absence of transcription.
Protein: SYE_MYCTU
Sequence: MTATETVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGTFVFRIEDTDAQRDSEESYLALLDALRWLGLDWDEGPEVGGPYGPYRQSQRAEIYRDVLARLLAAGEAYHAFSTPEEVEARHVAAGRNPKLGYDNFDRHLTDAQRAAYLAEGRQPVVRLRMPDDDLAWNDLVRGPVTFAAGSVPDFALTRASGDPLYTLVNPCDDALMKITHVLRGEDLLPSTPRQLALHQALIRIGVAERIPKFAHLPTVLGEGTKKLSKRDPQSNLFAHRDRGFIPEGLLNYLALLGWSIADDHDLFGLDEMVAAFDVADVNSSPARFDQKKADALNAEHIRMLDVGDFTVRLRDHLDTHGHHIALDEAAFAAAAELVQTRIVVLGDAWELLKFFNDDQYVIDPKAAAKELGPDGAAVLDAALAALTSVTDWTAPLIEAALKDALIEGLALKPRKAFSPIRVAATGTTVSPPLFESLELLGRDRSMQRLRAARQLVGHA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCD96_MACFA
Sequence: MEGGSEHTKDPGGEGGDGESLAARPSKIKASSGPPTPPEPGELESEPEEEEEEEEEEEEEASQGGTAADEQAKVPKELTAAEAAGEEGPGEPGRPAKPQPEPEEPAEAGAEEPVQPKSGAGPEELDAEARAEELEQAAEGKEVRSQASLPLTRIGEEEAAAAPEAETERVEGEEEDEEETRRDGAESEGRAGEGRPAKSQEEGKPLGGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLMERNRSQRYNLYLQHKIFEALRKKKGLEAAEVPDRGAQAEAPEKEQAYLRHLGMLEDLKKQQADDLQWYHQELGQLKQQCQEKLSRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQILALEDKKEKEMSAVRLENVQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRNKVTNSVQVITHMKEKLHFMDTENACKKKQLAEIEAQVAQGRDILTKTKQAREGLRTDNIRLNQKCGLLGNDSLLRDLEEKVDKTQLLHQRLESLKRHHAGLTLSCRGVRQKIREAKAFLPS
What are the official names of this protein?
Coiled-coil domain-containing protein 96.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: PAND_BACC0
Sequence: MFRTMMRAKLHRATVTEANLNYVGSITIDEDLMDAVNIVENEKVQIVNNNNGARLETYVIKGERGSGVVCLNGAAARLVQPGDKVIIICYGLVAEENIHKQEPKIAVLDDDNQIIEMLGAEKAGTIL
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.