PharMolix/UniProtQA huggingface dataset:
Protein: RIPR3_MOUSE
Sequence: MSVRLRFLSQGDAGAVGTVGRSASFAGFSSAQSRRLSKSINRNSVRSRLPAKSSKAYRTLRKGSLCLDPRPQQVKKIFDALKRGLREHLCEQQAELDYLCGRHTDTQRGSRLAFYYDLDKQLRLVERHIRKVEFHISKVDELYEAYCIQWRLRDGASNMQRAFSNSTQSRASRESLQELGRSLQECLEDMCLIEGTLEGHLGEFQVKMKGLVGYARLCPGDQYEVLMRLGRQRWRLKGRIEPDDSQTWDEEERVFVPTVHENLEIKVTELRGLSSMVVGAVTCDVADFFMARPQLVVVDITELGTIKLQLELLWNPLDSECRLVSPSPTGRFSMGSRKGSLYTWTPPSTPSFRDKYYLSLLQQPVQQSLLLGGPKATSILGYLSDSELQGPRLRSRSQELLEMDSFSSEDPRDTETSTSASTSDVGFLPVPVGSAACTEEETREGPPPLGLLPGLAHPARGVLVERPGWRDLGGERLALLQDAPIHSPMVPRSRKGQEDGDVGDGVEGPVQEVLDLLRSADPAQPQLRELEYQVLGLRERLKPRGVQPEPVSAQSLMDCILESFAFLNADLASDELSLFGGSQAPERDSPPPPRPSLKVSPSELTAGAPELDTLLTVHLQVCKALLQKLASPNLSRMVEDCLLEEAVQQRQVLEVLSDLDLEQVSKARSVEEIIPQASHRKGGLALWQGCTQPGGVLACPASTLLSQLKKTFLHRVRGKYPGQLEIVCRRLLEQVVGCGGLLVPAGLQEEQVVTWFQFHSYLQRQSISDLEKHLAQLTKEVTLIEELSCAGPAKALRKLHGKCLSQLQPLPQTLQAWALLQLDGPPRLCRAARTRLASAARNKRFREKALLYYTNALNDSDAKVQQAACVALQQLGGIESCEQIVSLCQSDLEAVRVAAREATLSFGEKGRLAFEKMDKLHSEQEAFCQEADVEITIF
What are the official names of this protein?
RIPOR family member 3.
What is the protein family that this protein belongs to?
Belongs to the RIPOR family.
Protein: HIS2_ARTS2
Sequence: MKNFETLFAELSEKAATRPAGSRTVAELESGVHGIGKKVVEEAAEVWMAAEYESDEAAAEEISQLLYHLQVLMLAKGLTLEDVYKHL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZSWM7_DANRE
Sequence: MGSSLVSVAEQLLKDLQRTYSEIKQIPDDLLIALRFVFGPCALQALDLVDQHSVTCVSSPSGRKAFQVLGGSGRLYTCFTSCHYCPCPAFSFTVLRRNESLMCKHLLAVILSQAMGLCQQEQVSDQQMTHILSRQPEAST
What is the function of this protein?
Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
What are the official names of this protein?
Zinc finger SWIM domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the SWS1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MENH_ECOLI
Sequence: MILHAQAKHGKPGLPWLVFLHGFSGDCHEWQEVGEAFADYSRLYVDLPGHGGSAAISVDGFDDVTDLLRKTLVSYNILDFWLVGYSLGGRVAMMAACQGLAGLCGVIVEGGHPGLQNAEQRAERQRSDRQWVQRFLTEPLTAVFADWYQQPVFASLNDDQRRELVALRSNNNGATLAAMLEATSLAVQPDLRANLSARTFAFYYLCGERDSKFRALAAELAADCHVIPRAGHNAHRENPAGVIASLAQILRF
What is the function of this protein?
Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).  Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.
What are the official names of this protein?
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, SHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MenH family.
Protein: NHAB_PSEA8
Sequence: MSSPLSQAFAQNFLGHSPRWYKLTVLAFLLLNPLLLWLAGPVTSAWVLVGEFIFTLAMALKCYPLQPGGLLVLEALLLGLATPEALYAELQHNFPVLLLLMFMVAGIYFMKDLLLLLFSRLLLGVRSKTLLSLLFCLLAALLSAFLDALTVTAVVISVAVAFFAVYHRVASGQRASEDYDPATDRQVPELHRAHLEEFRAFLRSLLMHAAVGTALGGVCTLVGEPQNLLIGHEAGWHFVEFFRQVAPVSMPVLAAGLLTCVLLEKSRRFGYGAQLPAAVRQVLAEYAASESRKRGAQQKAALLVQALAALVLIVGLALHVAEVGLIGLLVIVLITAFTGVTDEHQIGRAFQEALPFTALLVVFFAVVAVIHQQHLFTPIIQAVLALPAERQPGMLFIANGLLSAISDNVFVATIYITEVKQALDAGHMSREHFDTLAVAINTGTNLPSVATPNGQAAFLFLLTSSIAPLVRLSYGRMVWMALPYTLVMGGLGWWAVSHWL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IXOSN_IXOSI
Sequence: MSAHKVQIGLSSGQFRVALQVPSVRLKGLGSFHTGSIVLPSQGSLREDQISLHNQDGLHKVMREVLGYERNSYKKFFLR
What is the function of this protein?
Has antifungal activity against C. albicans.  Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli.  Lacks hemolytic activity against rabbit erythrocytes.
What are the official names of this protein?
Ixosin.
Protein: RL34_GEOSM
Sequence: MKRTFQPSNTSRKRTHGFLVRMATKNGRLVIKRRRAKGRKRLSVSIATK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: YQGF_YERPG
Sequence: MANRTIIAFDFGTKSIGVAIGQEVTGTARALTAFKAQDGTPDWQQVEKLLKEWQPNLVVVGLPLNMDGTEQPLTARARRFANRLHGRFGVQVALQDERLSTVEARANLFDRGGYRALDKGSVDAASAVIILESWFDEQAG
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAG2_YEAST
Sequence: MVEPDMQKKASGGSGGSEMDTLNATSNSSKQGVSNNKRNPVSKKKPGNKVSDGRDNAHNYHGEGRRKSSKQQRSRTPYKETSTRINDQDIDLSIQEEILGGNFKLRGRKTQVSINHLLNFQLPEVEREKSRSSSSKKSNRRRDEHVHLHGDTFVNVNYRLLVDDRFDYPEQNCNPNVPVDQEKILRVIVPKGQNCSICLSEEPVAPRMVTCGHIFCLSCLLNFFSIEETVKNKETGYSKKKKYKECPLCGSIIGPKRVKPVLYEDDFDVTRLNQKPEPGATVHLQLMCKPHGSLLPLPVALHLDPLKCGNFPPANLGSIKHYAHIMKCGVSYSLELYQKDIVAIQEQYEIDKAIYNDSGKFVKQSIENINDQISTLLAATTDLSPLSNDINNGLDNFHFDDDLLTKYDDSSAYFFYQTLVASSTKYFLSPLDVKILLTIFHYYSKFPESIETTVENIHYDTVVTEQLIRRYKYIGHLPIGTEIALLDLDWRKIPFLPKEIYEQFAHELKQRRRKFTMKKQKEDKEKKLYEKRLEQEHAEFYRKENGNSLKFEDSVQMATHYESIVSSSIPLNSLGISMLGPPTNSCSTPQKQAPSHTKRTIWGTSIAVTEDEKASKENKEFQDMLLQRIRQEDSSDVTDSTDSPPTSNGKRGRKKKGKVMLFSSNHQALG
What are the official names of this protein?
RING-finger protein MAG2.
What is the protein family that this protein belongs to?
Belongs to the RNF10 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHUT_ADE40
Sequence: MEEDLKLQPDSETLTTPNSEVGAVELVKHEEENEQVEQDPGYVTPPEDGKEPVAALSEPNYLGGEDDVLLKHIARQSTIVREALKECTQTPLTVEELSRAYEANLFSPRVPPKKQPNGTCETNPRLNFYPVFAVPEALATYHIFFKNQRIPLSCRANRTRGDGLLHLKAGAHIPEIVSLEEVPKIFEGLGKDEKRAANALQKNETENQNVLVELEGDNARLAVLKRTIEVSHFAYPALNLPPKVMRSVMDQVLIKRAEPIDPQQPDLNSEDGQPVVSDDELARWLGTQDPSELQERRKMMMAAVLVTVELECLQRFFANPQTLRKVEESLHYAFRHGYVRQACKISNVELSNLISYMGILHENRLGQNVLHCTLQGEARRDYVRDCIYLFLILTWQTAMGVWQQCLEEQNLQELNKLLVRARRELWTSFDERTVARQLANLIFPERLMQTLQNGLPDFVSQSILQNFRSFVLERSGILPAMSCALPSDFVPLCYRECPPPLWSHCYLLRLANYLAHHSDLMEDSSGDGLLECHCRCNLCTPHRSLVCNTELLSETQVIGTFEIQGPEQQEGASSLKLTPALWTSAYLRKFIPEDYHAHQIKFYEDQSRPPKVPLTACVITQSQILAQLQAIQQARQEFLLKKGHGVYLDPQTGEELNTPSLSAAASCRSQKHATQGKQASHRATAIPAETTKAVGRGGDVGRQPGRGSFRRGGGGADGELGQPRRGGPRGRGGRNHRQRQGTIFQKTRSEPTSENYPAPATATMFTESQP
What is the function of this protein?
Protein that inhibits host translation while promoting late viral translation by ribosome shunting.  Blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation.  Binds to the tripartite leader sequence of viral late mRNAs and recruits host eIF4G, PABPC1/poly-A binding protein and 40S ribosomes subunits on viral mRNAs, allowing ribosome shunting and efficient translation of late viral mRNAs even though conventional translation via ribosome scanning from the cap has been shut off in the host cell.  During assembly, acts as a chaperone protein that helps hexon proteins assembly into trimers.
What are the official names of this protein?
Shutoff protein, 100 kDa protein, p100K, 100K-chaperone protein, L4-100K, Shutoff protein 100K.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae shutoff protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: URED_JANMA
Sequence: MKRLSDTSSAITHTNKSGIASFRNDQARLSLAFTDDAGTTRMTERSHFGPLRVQKTLYPEHPAVCHAIIVHPPGGIVGGDQLTITARVGDRAHALLTTPGAGKWYRANGQLSQQQVSLEVGADAALEWLPQETIFFNEADVRLEHNVTLAADARYIGGEILCFGRTASGETFDSGRVAQRTSIRRGGKLLWFEQGALQARSTSMHSPLSLAGYTVCATLIAVGKTMNGAFLNELREESSALAQGGRSGATQMKQVLVARYLGHSSETARLWMTRAWQRIRPELMQRDAVIPRIWNT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WETA_PENRW
Sequence: MFAQPYDHSFNDLFNQYVNMETSAVDGKDSALSDFDQLFPLDSLSSDCGDLPPTVSTPKRHQSPQPWSNEWSLQDDGAAADHFAFHDTVHPSAISDVNLNNFEVPSRPTASHGLSTSPSTPPATPRRKPTQSALITPKSIRHRSPNERRSHLRKQSFSPSLMRSSNLSKARMAYPEAWAQRLQNFSLHGSEDRLPLSPPPSDVLIQHENMPTEQIMNQHGDSAERPSQYDARLYQQSPSVSMPSPSIAMSARQQQHYIAQPSSSSLTNSSPSSADDIFSSSHSSDPHSLSSWQSDPLHASSLSFTPDLQGQDSQWWSPMPSRVAQQQAAYLTSPTPVRTMQSVGSQNDMMQGGLMIQFNPSYDMSADHSFSSSNMLPATPQKFDTSFNTSQVHNVSRSPSLSPKAGTSPRDTRNGSISKPTHRRTHSRKLSGQSMNAPKPAKASGSSSRGSNKSVSVSFVNFTAHDSKKILTGVAPSGSSKTKARREQEARDRRRKLSEAALRAVRSAGGDVEALEAVLC
What is the function of this protein?
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity).  They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity).  Responsible for activating a set of genes whose products make up the final two conidial wall layers or direct their assembly and though this activity is responsible for acquisition of spore dormancy (PubMed:8078481).
What are the official names of this protein?
Developmental regulatory protein wetA.
What is the protein family that this protein belongs to?
Belongs to the wetA family.
Protein: PPSA_METTH
Sequence: MTGARNWLNKPLIFFKFNNHHTASPGDKMVKYVAFFEELGKDDVGIAGGKGANLGELTQAGIPVPPGFVVTAATYDKFMTDTGLQPVVMEMLENLDVNDTKELQRVSAEIKDIITSTEVPEDIQTLIIESYNALCQRIGKDDVYVAIRSSATAEDLPEASFAGQQDTFLNIRGAEDVLDYVRRCWASLFEARAIFYREENNFDHSKVYIAVVVQEMVDAEKAGVMFTVHPSTGEDRILIEGSWGLGEAVVSGSVTPDTYWVDKGTGKLLEFTVGEKNIMFTREDGRTVKKEVPPELRNKRVLSDGEIAALAEMGRRIQDHYGSPQDTEWAIMDGDVYMLQSRPITTLGEATEETEVKSREILVKGLGASPGLASGRVKIIREIHELDKIQIGDILVTVMTTPDMVPAMKRASGIITDEGGVTCHAAIVSRELGIPCVVGTGNATEVLKENQVVSIDGNRGLVYEGSVIEGEKKEAEAETVTVESPLLTVTEVKVNVSMPEAARKAAATGADGVGLLRTEHMMLTTGVHPRKFIEEGREDELVNTLAENILKVADEFYPRPVWYRTLDAPTDEFKTLEGGENEPYEHNPMLGWRGIRRELDEPEILRAEFRAIKKLHEQGYTNIGIMIPLVQHPDELRKAKMIAEEAGLKPHRDVEFGIMVETPAAALIIEDFIEEGIDFVRLEP
What is the function of this protein?
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
What are the official names of this protein?
Probable phosphoenolpyruvate synthase, PEP synthase, Pyruvate, water dikinase.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
Protein: RLMN_SHEB2
Sequence: MSEKKINLLDLDRKAMRALFADMGEKPFRADQLMKWLYHFGVSDFEEMTNINKVLRQKLAARCEIVAPEISSFQKSTDGTIKFAINVGQGQEVETVYIPEDDRATLCVSSQVGCALECTFCSTGQQGFNRNLTVSEIVGQIWRVSHFLGFAKDTGERPITNVVMMGMGEPLLNLANVIPAMDIMLDDFGFSLSKRRVTLSTSGVVPALDKLGDAIDVALAVSIHAPNDELRDILVPINKKYPLDEFLAGIRRYIAKSNANRGRVTVEYVMLDHINDSTDQAHELAKLMKDTPCKVNLIPFNPYPGSPYGRSSNSRIDRFSKVLMEYGFTVIVRKTRGDDIDAACGQLAGDIRDRTKRLAKKRMQENQISVTMN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPAT_PROMA
Sequence: MVQVNSNYLKLKAGYLFPEISRRVNAFCELNPTASLIRLGIGDVTEPLPQACCKAMKTAIEEMGSTSGFRGYGPEQGYLWLREAIAKNDFQSRGCQISADEIFVSDGSKCDSSNILDILGTGNKIAVTDPVYPVYVDSNVMAGQTGIAASSGHYEGLVYIPLNAENGFEAELPSEPVDLIYLCFPNNPTGAVASKVQLTKWVEYAKKNHALILFDAAYESFIQDPLLPHSIFEIDGATDCAIEFRSFSKNAGFTGTRCAFTVIPKSLKGKTLDGAEVDFWSLWNRRQSTKFNGVSYIVQRGAEAVYSLEGQSQTNKLVSFYMKNAEIIRKQLTLAGYKIYGGKHAPYVWLEAPTEMDSWQFFDHLLNKANIVGTPGSGFGVAGEGYFRLSAFNSRSNVEEAMRRITSI
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
What are the official names of this protein?
LL-diaminopimelate aminotransferase, DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: BZLF1_EBVB9
Sequence: MMDPNSTSEDVKFTPDPYQVPFVQAFDQATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAPQPGDNSTVQTAAAVVFACPGANQGQQLADIGVPQPAPVAAPARRTRKPQQPESLEECDSELEIKRYKNRVASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDLLNF
What is the function of this protein?
Transcription factor that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle (PubMed:8404860) (Probable).  Mediates the switch from the latent to the lytic cycle of infection in cells containing a highly methylated viral genome (PubMed:34893887, PubMed:15361873).  Probably binds to silenced chromatin and recruits host chromatin-remodeling enzymes (PubMed:30926617).  Regulates this switch by binding to 2 types of ZEBRA response elements (ZREs): the CpG-free AP-1 like elements (latency) and the methylated CpG-containing elements (lytic replication) (PubMed:34893887, PubMed:22022468) (Probable).  Activates preferentially the methylated forms of the viral lytic R (BRLF1) and Na (BRRF1) gene promoters, the latters being the first genes activated during Z-mediated reactivation in latently infected cells (PubMed:19325883, PubMed:15361873).  BZLF1 and BRLF1 act together to trigger lytic replication (PubMed:10856251, PubMed:15361873).  Also binds the lytic origin of replication, oriLyt (PubMed:20808903).  Induces G1 cell cycle arrest by stabilizing the host CCAAT/enhancer binding protein CEBPA (PubMed:15078966).  This function is important because the lytic cycle preferentially takes place in host cells arrested in G1 (PubMed:15078966).
What are the official names of this protein?
Lytic switch protein BZLF1, EB1, Protein Z, Trans-activator protein BZLF1, Zta, bZIP transcription factor ZEBRA.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: LIS1_COPC7
Sequence: MSLLSDRQKDDLHKAMLDYLYANNHTAAFNALKESAGITYTPDPTARYTGLLEKKWTSVIRLQKKIMELENRNAALQEELSMSPARRAASQADWLPRAPAAHVLTGHRAPLTSIAFHPQYSILASASEDTTVKIWDWETGEFERTLKGHTKPVNDLDFDHKGHLLVTCSSDLFIKIWDSQNEWKNTKTFVGHDHAVSAVRFMPGDQLIVSASRDRTIRVFDVASTHQVRTLSGHSEWVRCVIPSADGTMLASGSKDQTVRLWDPLTGEPKSELRGHENDVEAVAFAPISAYAAIRELAGIPNDRTKRHGLFLASGARDKTVKLWDTQTGQMIRNLAGHDNWVRALAFHPSGKYLLSSSDDKTVRVWELSTGRCLRIVEAHSHFVAALAWGRQAAGKSGSEKKVNGVDSVDAEPEKVVNVVATGSVDETIKIWLP
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for nuclear migration during vegetative growth as well as development.  Required for retrograde early endosome (EE) transport from the hyphal tip.  Required for localization of dynein to the mitotic spindle poles.  Recruits additional proteins to the dynein complex at SPBs.
What are the official names of this protein?
Nuclear distribution protein PAC1, Lissencephaly-1 homolog, LIS-1, nudF homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.
Protein: BBC3_RAT
Sequence: MARARQEGSSPEPVEGLARDSPRPFPLGRLMPSAVSCGLCEPGLPAAPAAPALLPAAYLCAPTAPPAVTAALGGPRWPGGHRSRPRGPRPDGPQPSLSPAQQHLESPVPSAPEALAGGPTQAAPGVRVEEEEWAREIGAQLRRMADDLNAQYERRRQEEQHRHRPSPWRVMYNLFMGLLPLPRDPGAPEMEPN
What is the function of this protein?
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis.  Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis.  Regulates ER stress-induced neuronal apoptosis.
What are the official names of this protein?
Bcl-2-binding component 3, p53 up-regulated modulator of apoptosis.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release.
Protein: PSRP_PSEAB
Sequence: MQMKRTAFFISDGTGITAETLGQSLLAQFENISFVKLTRPYIDTEEKARAMVQQINNAAESDGARPIIFDTIVNRDIRAVLAQSNGFMIDIFATFLSPLEQELSADSSYSVGKSHSIGHNSNYMDRIEAVNFALDNDDGARTHYYDKADLILVGVSRCGKTPTCLYMALQYGIRAANYPLTEEDMERLQLPNALKQYKHKLFGLTIDPDRLTAIRNERKPNSRYASFAQCEFEVREVESLFRRENIAYINSTHFSVEEISAKILVEKGVERRFK
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: COQ3_BOVIN
Sequence: MWGGSKLSSSGSRFLGALRSGFQSTQVDSSRLTTSAVYPKNQLSWILQIKPWVFNENRIMWFKSYSITFACLNWMKSYRLPWTRPYSTSRTTVDKNEMKTFLALAHRWWDEQGVYAPLHSMNDLRVPFIRDNLLRTVATHQPGKPLSGMKILDVGCGGGLLTEPLGRLGASVIGIDPVDENIKTAQHHKSFDPVLDKRIEYRTCSLEEIVKDTVETFDAVVASEVVEHVIDLETFIQCCFQVLKPDGSLFITTINKTQLSYALGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILESNGLSVQTVVGMLYNPFSGYWHWSENTSLNYAAHALKSSLQEQPAPAEFALKGEAEELQAEASTNSGVQEDLKK
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, mitochondrial, 3-demethylubiquinol 3-O-methyltransferase, Polyprenyldihydroxybenzoate methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RL32_MYCBO
Sequence: MAVPKRRKSRSNTRSRRSQWKAAKTELVGVTVAGHAHKVPRRLLKAARLGLIDFDKR
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: Y1499_STRS7
Sequence: MDPKKIARINELAKKKKTVGLTGPEKVEQAKLREEYIEGYRRSVRHHIEGIKIVDEDGNDVTPEKLRQVQREKGLHGRSLDDPES
What are the official names of this protein?
UPF0291 protein SZO_14990.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_MYCS2
Sequence: MPTYTPKAGDTTRSWYVIDASDVVLGRLASAAATLLRGKHKPTFTPNVDGGDFVIVINADKIAVSGDKLTKKFAYRHSGYPGGLRKRTIGELLEKHPTRVVENAIIGMLPHNKLGRQIQKKLKVYAGPDHPHAAQQPIPFEIKQVAQ
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: SYH_SERP5
Sequence: MAKNIQAIRGMNDYLPEETALWQRIEGILKQVLSGYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFDDRNGESLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYVGPMFRYERPQKGRYRQFHQLGAEVFGLQGPDIDAELILLSARWWKALGISEHVKLELNSIGSLEARANYRDALVAFLEQHQEKLDEDCKRRMYSNPLRVLDSKNPEVQALLNDAPRLSEYLDADSKAHFEGLCELLAQAGIPYTINERLVRGLDYYNRTVFEWVTTSLGAQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFKAAATIDVYVISSGAGTQSAAMQLAERVRDAAPQLKLMTNYGGGNFKKQITRADKWGARVALILGENEVAAQQVVVKDLRSGEQETLAQSEVAVRLALMLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YWQN_BACSU
Sequence: MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIEDLRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPRFPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGDILRDHQALSAASRLLKRSDAI
What is the function of this protein?
Putative NADPH-dependent oxidoreductase.
What are the official names of this protein?
Putative NAD(P)H-dependent FMN-containing oxidoreductase YwqN.
What is the protein family that this protein belongs to?
Belongs to the SsuE family.
Protein: HIS4_VEREI
Sequence: MLLIPAIDLKDGHCVRLRQGDMDQSTTFGENPAAMARQWIDAGARRLHLVDLNGALAGMPKNYGAIKSILKEVGDDIPVQLGGGIRDLDTIEKYIDGGLRYVIIGTAAVKNPGFLKDACSAFGGHIIVGLDARDGKVATDGWSKLTGHGVVDLARKFEDWGVESIIYTDIGRDGMLSGINIDATVALAQALSIPVIASGGLSGMADIEQLCAVQDEGIEGVICGRAIYSGDLDFAAAQARADEMG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYC_CAEBR
Sequence: MFARAVSRKTMTGLLAGSRVLLASQFTMADRQVHTPLEPVQRQKYANNENLLKDHVEKIDPEVFNIMKNEKSRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYGGNEFIDQMEILCQKRALEVFGLDPAKWGVNVQSLSGSPANFAVYTALVGANGRIMGLDLPDGGHLTHGFFTPARKVSATSEFFQSMPYKVDAQSGLIDYDKLEENAMLFRPKVLIAGVSCYARHLDYERFRKIATKAGAYLMSDMAHISGLVAAGLIPSPFEYSDVVTTTTHKSLRGPRGAMIFYRKGVRSVNAKGVETLYDLEEKINSAVFPGLQGGPHNHTIAGIAVALKQCLSEDFVQYGEQILKNAKTLAERLKKHGYSLATGGTDNHLLLVDLRPIGVEGARAEHILDLAHIACNKNTCPGDVSALRPGGIRLGTPALTSRGFKEQDFEKVGDFIHEGVQIAKKYNAEAGKTLKDFKAFTATNEQFKQEVAELAKRVEEFSGKFEIPGNDLF
What is the function of this protein?
Interconversion of serine and glycine.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Glycine hydroxymethyltransferase, Maternal effect lethal protein 32, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
Protein: AGTRB_XENLA
Sequence: MLSNISAGENSEVEKIVVKCSKSGMHNYIFITIPIIYSTIFVVGVFGNSLVVIVIYSYMKMKTMASVFLMNLALSDLCFVITLPLWAVYTAMHYHWPFGDLLCKIASTAITLNLYTTVFLLTCLSIDRYSAIVHPMKSRIRRTVMVARLTCVGIWLVAFLASLPSVIYRQIFIFPDTNQTVCALVYHSGHIYFMVGMSLVKNIVGFFIPFVIILTSYTLIGKTLKEVYRAQRARNDDIFKMIVAVVLLFFFCWIPHQVFTFLDVLIQMDVIQNCKMYDIVDTGMPITICIAYFNSCLNPFLYGFFGKKFRKHFLQLIKYIPPKMRTHASVNTKSSTVSQRLSDTKCASNKIALWIFDIEEHCK
What is the function of this protein?
Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:8355665).  The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (By similarity).
What are the official names of this protein?
Type-1 angiotensin II receptor B, Angiotensin 2 receptor, type 1-B, Angiotensin II receptor, type 1-B, Angiotensin type 1 receptor, AT1 receptor 1, XAT-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.