PharMolix/UniProtQA huggingface dataset:
Protein: NS7B_FIPV
Sequence: MIVVILVCIFLANGIKATAVQNDLHEHPVLTWDLLQHFIGHTLYITTHQVLALPLGSRVECEGIEGFNCTWPGFQDPAHDHIDFYFDLSNPFYSFVDNFYIVSEGNQRINLRLVGAVPKQKRLNVGCHTSFAVDLPFGIQIYHDRDFQHPVDGRHLDCTHRVYFVKYCPHNLHGYCFNERLKVYDLKQFRSKKVFDKINQHHKTEL
What are the official names of this protein?
Non-structural protein 7b, ns7b, Accessory protein 7b.
Protein: CAH3_CAEEL
Sequence: MTGHWSYCDDDECGPNRWPTGQHQSPINIDLGEVERKDTHDGIKFVNYDHPIQGDIVNNGHSVQMTPELRSEHPEIYGGGLDQVYRLVQYHFHWGENDNEGSEHTLGGLRYPAELHLVHQGVEDPGKLAVVGVFLQLGKEGKALSNEERVLGKLCNPETVTRVENVRLSEKLPANKRSFWRYEGSLTTPPCSEIVTWTIFTEPVTVTHDQLELFRQVQDIEKRPIKKNYRPTQNLNDRKIVHIVAN
What is the function of this protein?
Reversible hydration of carbon dioxide.
What are the official names of this protein?
Putative carbonic anhydrase 3, Carbonate dehydratase 3.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
Protein: FTSK1_RALSO
Sequence: MGLGWFGISSVWLLPMVWRYVARVMAGERGLKGPGTVRIWLATLAVLCASASLEALTSGRDLHGKAGGAVGRGLASLFGHMLGWTGAFLLMLGVLLWVAPMVFGHSWRQLLARLRQAGEAPPVQADARHDEADDGLKPTALGLGGAEQAMGSGHAGASRRHGIEAGSAWRQPAWQPPPRTRESPPQPGEIWPLLNAQGRPEMPLPVAAQPAPVPVPAPAATPKAATQAPSSRSALRATIVSSPFHRPQPSDGDQPPSSPEADDAPSAPVEDAAPAISPAAEPDAPASAPPEPAEPSPPTVDLEAVRQEAEALLAELRGLMTPLAAAPVASPEPEPEPEPEAETEVTPEAEAEPEAEPEAEAEPEAEAEAEAEAEAEPEAEAPAPESVAPALQEAEAATAAEAPLPAPEPAPAIEADDAAPPPPAVPAQKPRIVLPAVVGQVVSNAMPAPAPAAAPVAAAPPAPPRVVDYRLPNVALLTAASPDTVAVPAEHLEETSHLIAQRLAEFKVPVTVAGASAGPVITRFEVDPAIGVRGAQVVGLMKDLARALGVTSIRVVETIPGKTCMGLELPNARRAMIRLSEVVNAPDFQSHASHLVLAMGKDITGNPVVTDLARAPHLLVAGTTGSGKSVAVNAMILSMLYKATPEDVRLIMIDPKMLELSVYEGIPHLLAPVVTDMKQAAHALNWCVGEMEKRYRLMSALGVRNLAGYNQKIRAAQQAGHKVPNPFSLTPDAPEPLSTLPMIVVVIDELADLMMVAGKKIEELIARLAQKARAAGIHLILATQRPSVDVITGLIKANIPTRVAFQVSSKIDSRTILDQMGAETLLGQGDMLFLPPGTGYPQRVHGAFVADEEVHRVVEHWKQFGEPEYDEAILAGDPAEAAAGELFGEGGDAEADPLYDEAAAFVLNTRRASISAVQRQLRIGYNRAARLIEQMEAAGLVSPMGRNGSREVIAPGGGD
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination.  FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation.  FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
What are the official names of this protein?
DNA translocase FtsK 1.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: UPK1A_BOVIN
Sequence: MASAAAATTEKGSPVVVGLLVMGNIIILLSGLALFAETVWVTADQYRIYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRSMILTYLILMLIIYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADSNQGRELTRLWDRIMIEQECCGTSGPMDWVNFTSAFRATTPEVVFPWPPLCCRRTGNFIPVNEEGCRLGHLDYLFTKGCFEHIGHAIDSYTWGISWFGFAILMWTLPVMLIAMYFYTTL
What is the function of this protein?
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells.  May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
What are the official names of this protein?
Uroplakin-1a, UP1a, Uroplakin Ia, UPIa.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FAO1_LOTJA
Sequence: MRKECHPLLRGGRKDNKFRQGFSSSEMESLASICEVILPPLPMDALKIKKHDDVSIEDVEFFWNTSASHYPIPHEVAEILSKRSLIEAVILIRVVLWLLATRLGTFLLCGLLCFSEKWPFINNFSSMSLKKRERVMQWWLKNRFITPIRLAFAYLKVLCLFAYFTWVDENGDNPAWKAIGYEVSADEKLPNSSNGRLLEKGIVETMHETNSTLQQSLTEKGLNVTLDSRNNILKVKCDAIVVGSGCGGGVAASVLSGAGHKVVVLEKGNYFAPRDYSSLEGPSMDQLYETGGILASVDSRILLLAGSTVGGGSAVNWSACIKTPHEVLKEWSENHNLSLFSTSEYLSAMETVCERIGVTESCTHEGFQNQVLRKGCQNLGLKVDYVPRNSSGNHFCGSCGYGCPKGEKQGTQDTWLVDAVENGAVIITGCKAERFLLENNRNGSGRKKKCLGVLAKALSSRVTMKLQIEAKVTISAGGALLTPPLMISSGLKNKNIGKNLHLHPVLMTWGYFPESTSELKGKIFEGGIITSVHKVPSRDSNSYSDTRAIIETPSLGPGSFASLCPWESGLDFKERMLNYPRTAHLITIIRDKACGQVTTEGRVSYKLSAFDKENMKCGLQQALRILKAAGAVEVGTHRSDGQRVKCGEVSENEMAEFIDSVCPMEGALSPGENWNIYTSAHQMGSCRMGMNEKEGAVDENGESWEAQGLFVCDASLLPTAVGVNPMITIQSTAYCISNRVVDYLKRDQI
What is the function of this protein?
Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.
What are the official names of this protein?
Long-chain-alcohol oxidase FAO1, Long-chain fatty alcohol oxidase 1.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ST1C2_RABIT
Sequence: MALATGPGKQTQLREVEGVPLQAAIVDNWGQIQSFEAKPDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCQRALIQHRHPFIEWARPPQPSGVEKAQAMPSPRILRTHLPTRLLPPSFWENNCKFLYVARNVKDCMVSYYHFQRMNQVLPDPGTWEEYFETFINGKVAWGSWFEHVKGWWEVKGRYQILFLFYEDIKKDPKCEIRKVAQFMGKHLDETVLDKIVQETSFEKMKDNPMINRSTVPKSIMDQSISPFMRKGTVGDWKNHFTVAQSHRLDELYRKKMEGVSIDFCLEL
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation.  Sulfonates p-nitrophenol, a small phenolic compond.  Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol.
What are the official names of this protein?
Sulfotransferase 1C2, ST1C2, rabSULT1C2, Sulfotransferase 1C1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome.
Protein: YPTJ_CAEEL
Sequence: MRWFINYKPCLLIILIFNSVILLFILIRKSSQPFSNILTDPSGTSREKLPVSHAFINSVYYYPTSKSLGENALAFTMAIDQHSYSMKNHTFTVLGYNSTDSVESIATSQTEGISRCRYVTMMARTNTVENLEKLKIESQGVSVEVPFRIARYSAPKPVIICISPQFAAEQWQMFVMHVHAANRFGGHLHIYLTSIIESYFQLMQEYERQGYITLDYWLRMKFSNTKTPYYEPNENVEWRHQAGAQTDCLLQYKEAAEYIAFFDMDDILFPKNYPTYLEEFNSVLAANPGKNYLFYGRREHEFVKASTLTEFSFTELVQSLRSSQTVKRGKVVVRPEAYNSTWIHNSKHVSFETSVQVKSPTLVHVQLPVDKNGKRNDSRDLWKIKFGPLNETIREDDIRAIEDDINRIKNLAVISSIGPFLPSSDFYLPIVFKCYFDSFYKDTFVTKIGVRRCPNADICDLPQREDYKCIHSDAQYYSGPDMQPVTYHFTTDSFWSKDIGCYQ
What are the official names of this protein?
Glycosyltransferase family 92 protein ZK381.2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 92 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PETG_PLETE
Sequence: MVEALLSGIVLGLVPVTILGLFVTAYLQYRRGDRVTSSF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MOBA_BRUAB
Sequence: MRAGQPKITGAKITGAIIAGGQSSRMQAGGVSGDKFLQPLGSAPVIAHVIARLQPQVDTLFINSKGDLSRFAAFGLPAVKDIAMNHGGPLVGLLTCLAHASPCRLLLTSAADTPFLPCDLASNLIRKQAETGARIILACSNERVHPIVGLWHTDLVPDLEKWLQHAEKASIFWFAKHIGFEVVNIPLAHAPRLAESYDPFFNINLPDDLLKAREINEALQA
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTLC_BORPA
Sequence: MNRRGGQTAFAAIARNERAIAAFIPYSSHLTDTTLITHGADLVRTWRVQGIAFESAEPELVSQRHEQLNGLWRAISCEQVALWIHCIRRKTQAGLDARYENPFCRALDASYNARLNARQAMTNEFYLTLVYRPGHAALGKRAHHGQAEVRRQLLAHVRRMDEIGSLIETTLRSHGENHEQAITVLGCETDSAGRRYSRTLTLLEFLLTGHWQPVRVPAGPVDAYLGSSRILAGAEMMELRSPTCRRYAQFIDFKEYGTHTEPGMLNALLYEDYEYVITHSFSAVGKRQALAYLQRQRAQLANVQDAAYSQIDDLAHAEDALVNGDFVIGEYHFSMMILGADPRQLRRDVSSAMTRIQERGFLATPVTLALDAAFYAQLPANWAYRPRKAMLTSRNFAGLCSFHNFYGGKRDGNPWGPALSLLSTPSGQPFYFNFHHSGLDEDCRGQMMLGNTRIIGQSGSGKTVLLNFLLCQLQKFRSADADGLTTIFFDKDRGAEICIRALDGQYLRIRDGEPTGFNPLQLPCTDRNVMFLDSLLAMLARAHDSPLTSAQHATLATAVRTVLRMPASLRRMSTLLQNITQATSEQRELVRRLGRWCRDDGAGGTGMLWWVFDNPNDCLDFSRPGNYGIDGTAFLDNAETRTPISMYLLHRMNEAMDGRRFVYLMDEAWKWIDDPAFAEFAGDQQLTIRKKNGLGVFSTQMPSSLLGARVAASLVQQCATEIYLPNPRADRAEYLDGFKCTETEYQLIRSMAEDSHLFLVKQGRQAVVAQLDLSGMDDELAILSGNARNLRCFEQALALTRERDPNDWIAVFHRLRREASAGLR
What are the official names of this protein?
Type IV secretion system protein PtlC homolog.
What is the protein family that this protein belongs to?
Belongs to the TrbE/VirB4 family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RUVB_LIMRJ
Sequence: MENDHGILSDHPSGEEESQVEITLRPQKLREYIGQPKIKHELEVYIKAAQSREEALDHVLLYGPPGLGKTTLAMVIANEMGVNIRTTSGPAIEKPGDLVALLNELKPGDVLFVDEIHRLPKVVEEMLYSAMEDYYIDIVIGEGPTAHPVHFPLPPFTLIGATTRAGMLSAPLRDRFGIVEHMNYYTQDELTKIIFRSAKIFHTSIQDEGAHELSLRSRGTPRIANRLLKRVRDFAQVAGKQSIDSAIVKQALSLLQVDDRGLDEIDRKMLLTMINFYHGGPVGLKTIAANIGEETNTIEEMYEPYLLQIGFISRTPRGRLVTPTAYEHLGIEYPTDKN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ZNUC_MAGSA
Sequence: MSLLNLSGVRLSHGGHLVLDRVDLTVDAGRIITVVGPNGAGKSSLLKVALGLLRPDAGTVERGAKVIGYVPQRLDIGRLLPLSVRRFLAMAVAERPPAGRLEETLDLVGAGHVLGRQVVDLSGGEMQRVLLARALLRRPDLLVLDEPVGGVDVAGQAELYDLITGQAREHGVGVLMVSHDLHVVMAATDHVVCLNRHVCCAGHPETVSRHPEYLALFGPRVAASLAIYTHAHDHGHGADGSVLPLAEGGGEPHTHGPGCRHG
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TRFL_BOVIN
Sequence: MKLFVPALLSLGALGLCLAAPRKNVRWCTISQPEWFKCRRWQWRMKKLGAPSITCVRRAFALECIRAIAEKKADAVTLDGGMVFEAGRDPYKLRPVAAEIYGTKESPQTHYYAVAVVKKGSNFQLDQLQGRKSCHTGLGRSAGWIIPMGILRPYLSWTESLEPLQGAVAKFFSASCVPCIDRQAYPNLCQLCKGEGENQCACSSREPYFGYSGAFKCLQDGAGDVAFVKETTVFENLPEKADRDQYELLCLNNSRAPVDAFKECHLAQVPSHAVVARSVDGKEDLIWKLLSKAQEKFGKNKSRSFQLFGSPPGQRDLLFKDSALGFLRIPSKVDSALYLGSRYLTTLKNLRETAEEVKARYTRVVWCAVGPEEQKKCQQWSQQSGQNVTCATASTTDDCIVLVLKGEADALNLDGGYIYTAGKCGLVPVLAENRKSSKHSSLDCVLRPTEGYLAVAVVKKANEGLTWNSLKDKKSCHTAVDRTAGWNIPMGLIVNQTGSCAFDEFFSQSCAPGADPKSRLCALCAGDDQGLDKCVPNSKEKYYGYTGAFRCLAEDVGDVAFVKNDTVWENTNGESTADWAKNLNREDFRLLCLDGTRKPVTEAQSCHLAVAPNHAVVSRSDRAAHVKQVLLHQQALFGKNGKNCPDKFCLFKSETKNLLFNDNTECLAKLGGRPTYEEYLGTEYVTAIANLKKCSTSPLLEACAFLTR
What is the function of this protein?
The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions.  This function contributes to the antimicrobial activity.  Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites.
What are the official names of this protein?
Lactotransferrin, Lactoferrin.
What is the protein family that this protein belongs to?
Belongs to the transferrin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils (By similarity).
Protein: UBIA_ECO8A
Sequence: MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYYWSIVVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENO_BURM7
Sequence: MSAIVDIIGREILDSRGNPTVECDVLLESGTMGRAAVPSGASTGSREAIELRDGEAGRYGGKGVLKAVEHINTEISEAIMGLDASEQAFLDKTLLELDGTDNKSRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQLPVPMMNIVNGGAHANNSLDIQEFMIVPVSQPTFREALRCGAEVFHALKKILGDRGMSTAVGDEGGFAPNFGSNDECLSTILQAIEKAGYRAGEDVLLALDCAASEFYHDGKYQLAGEGLQLSSAEFTDYLATLADKFPIVSIEDGMHEGDWDGWKLLTERLGKKVQLVGDDLFVTNTRILKEGIEKGIANSILIKINQIGTLTETFAAIEMAKRARYTAVISHRSGETEDSTIADIAVGLNAGQIKTGSLSRSDRISKYNQLLRIEEDLGDIASYPGKSAFYNLR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: STYB_STYCL
Sequence: GXFGPAFHSVSNFAKKHKTA
What is the function of this protein?
Bactericidal against several Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Styelin-B.
What are the subcellular locations of this protein?
Secreted.
Protein: ACPY1_PAEHA
Sequence: MHIRMVGTGSAFAKKFDNNNALLEQDGCCLLIDCGITLPKALYQMGLAFPEIDAVLISHIHADHVGGLEEFAFQMMFKYNRKPVLFIADTLIEPLWEHTLRGGLTQDPLNKLEHFFDVRPIIANTETELFPGLRVKLLPTKHIPNKPSYSFLFNDRFFYSADMRFDKELLLRLADGGVQTIFHDCQLEEPGVVHASLNELLTLPESVQKKTWLMHYGDTIDQYQGRTGHMRIVEPQRRYEV
What is the function of this protein?
Counteracts the endogenous Pycsar antiviral defense system.  Phosphodiesterase that enables metal-dependent hydrolysis of host cyclic nucleotide Pycsar defense signals such as cCMP and cUMP.
What are the official names of this protein?
Anti-Pycsar protein Apyc1, Apyc1.
What is the protein family that this protein belongs to?
Belongs to the nuclease anti-Pycsar protein Apyc1 family.
Protein: MANA_ECOLI
Sequence: MQKLINSVQNYAWGSKTALTELYGMENPSSQPMAELWMGAHPKSSSRVQNAAGDIVSLRDVIESDKSTLLGEAVAKRFGELPFLFKVLCAAQPLSIQVHPNKHNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVSLLQPVAGAHPAIAHFLQQPDAERLSELFASLLNMQGEEKSRALAILKSALDSQQGEPWQTIRLISEFYPEDSGLFSPLLLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPANQLLTQPVKQGAELDFPIPVDDFAFSLHDLSDKETTISQQSAAILFCVEGDATLWKGSQQLQLKPGESAFIAANESPVTVKGHGRLARVYNKL
What is the function of this protein?
Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide.
What are the official names of this protein?
Mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI.
What is the protein family that this protein belongs to?
Belongs to the mannose-6-phosphate isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_SYMTH
Sequence: MAGQSRPDLIRIGQVTAPHGVRGAVRVYPTTDFPERFVTLKRVMIDGPDRAVGARFRGFVKNLVILELEGITDRNQAERLRGADLLVPREEVHPLPEGYYYDFDIIGIEVVDPDGRQLGRVVEVDHTSPVHDLYVVETAPGKRYLVPAVRRFVKEIDLETGRMVIDPIPGLLED
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_BIFLD
Sequence: MTQRVVSIVGPTASGKTGLGIAIARRLAEAGERAEIVNADAYQMYRGMDIGTAKPTAEEQAAVPHHLIDIIDPEDTMSVARFQQLARETIADLQSRGIRPILVGGSGLYARAAIDDITFPGTDPDVRTRLEEREKTEGAGALFDELRAKDPEAAARMDPRNPRRTIRALEVIELTGKPYSASLPRYRYVIPSVQIGLDLDRPDLDHRIDLRTKQMYDDGFIEEVERLRPHLGATAVRALGYQQIIDLLDGIWDVNDAFADIAQKTKRLARKQMGWFGRDPRIHWLQALNPKLVDNAMAIIAHADAGDYDPIDARADEYTQHHLGDITA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: LACC1_HUMAN
Sequence: MAEAVLIDLFGLKLNSQKNCHQTLLKTLNAVQYHHAAKAKFLCIMCCSNISYERDGEQDNCEIETSNGLSALLEEFEIVSCPSMAATLYTIKQKIDEKNLSSIKVIVPRHRKTLMKAFIDQLFTDVYNFEFEDLQVTFRGGLFKQSIEINVITAQELRGIQNEIETFLRSLPALRGKLTIITSSLIPDIFIHGFTTRTGGISYIPTLSSFNLFSSSKRRDPKVVVQENLRRLANAAGFNVEKFYRIKTHHSNDIWIMGRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEYGCSLEDIVVVLGPSVGPCCFTLPRESAEAFHNLHPACVQLFDSPNPCIDIRKATRILLEQGGILPQNIQDQNQDLNLCTSCHPDKFFSHVRDGLNFGTQIGFISIKE
What is the function of this protein?
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (PubMed:31978345).  Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345).  Also has adenosine deaminase activity (PubMed:31978345).  Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:31978345).  Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed:31978345).  The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345).  Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (PubMed:28593945, PubMed:31875558).  Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (PubMed:31875558).  Does not show laccase activity (PubMed:27959965, PubMed:31978345).
What are the official names of this protein?
Purine nucleoside phosphorylase LACC1, Adenosine deaminase LACC1, Fatty acid metabolism-immunity nexus, Guanosine phosphorylase LACC1, Laccase domain-containing protein 1, S-methyl-5'-thioadenosine phosphorylase LACC1.
What is the protein family that this protein belongs to?
Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endoplasmic reticulum. Peroxisome. Note=Upon stimulation of the pattern- recognition receptor (PRR) NOD2, localizes to the endoplasmic reticulum.
Protein: OXSR1_HUMAN
Sequence: MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
What is the function of this protein?
Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764).  Phosphorylates PAK1 (PubMed:14707132).  Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202).
What are the official names of this protein?
Serine/threonine-protein kinase OSR1, Oxidative stress-responsive 1 protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Protein: TRPB_BACC2
Sequence: MNYAYPDEKGHYGIYGGRYVPETLMQSVLELEEAYKEAMQDEAFQKELNHYLKTYVGRETPLYFAENMTKYCGGAKIYLKREDLNHTGAHKINNTIGQALLAVRMGKKKVVAETGAGQHGVATATVCALLGLECVIFMGEEDVRRQKLNVFRMELLGAKVESVAAGSGTLKDAVNEALRYWVSHVHDTHYIMGSVLGPHPFPQIVRDFQSVIGNETKKQYEALEGKLPEAVVACIGGGSNAMGMFYPFVHDEEVALYGVEAAGKGVHTEKHAATLTKGSVGVLHGSMMYLLQNEEGQIQEAHSISAGLDYPGVGPEHSLLKDIGRVSYHSITDDEALEAFQLLTKKEGIIPALESSHAVAYALKLAPKMKKDEGLVICLSGRGDKDVESIKRYMEEV
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RS4_MARSD
Sequence: MARYTKAKCRLCRREGEKLFIKGDRCFTDKCSYERRPYAPGIAGRMRKKMSDYAIQLREKQKVRRMYGVLEGQFRSYFKRADGMKGVTGANLLMLLETRLDNTVYRLGFANSRAQARQLVKHGIFTKNGRRVNVPSMHVKPGDVIEVREESRKIPVIAEAQEVIARRGCPEWLEADGANFKGEVKAMPTREDIQFPINEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.