PharMolix/UniProtQA huggingface dataset:
Protein: CUL1_CAEEL
Sequence: MTNSEPRRMTCDSEVVWKKLQDGLDVAYRRENMAPKDYMTLYTSVYDYCTSITLSTSRRDGEDGRAESSTPARTAGADFVGHEMYQRVEEYVKAYVIAVCEKGAELSGEDLLKYYTTEWENFRISSKVMDGIFAYLNRHWIRRELDEGHENIYMVYTLALVVWKRNLFNDLKDKVIDAMLELIRSERTGSMINSRYISGVVECLVELGVDDSETDAKKDAETKKLAVYKEFFEVKFLEATRGFYTQEAANFLSNGGNVTDYMIKVETRLNQEDDRCQLYLNSSTKTPLATCCESVLISNQLDFLQRHFGGLLVDKRDDDLSRMFKLCDRVPNGLDELRKSLENHIAKEGHQALERVAMEAATDAKLYVKTLLEVHERYQSLVNRSFKNEPGFMQSLDKAATSFINNNAVTKRAPPQAQLTKSAELLARYCDQLLRKSSKMPDEAELEELQTKIMVVFKYIDDKDVFSKFYTKMFSKRLISELSASDEAEANFITKLKSMCGYEYTARLSKMVNDTQVSKDLTADFKEKKADMLGQKSVEFNVLVLSSGSWPTFPTTPITLPQQLSKTIEIFGQFYNEKFNGRRLTWVYSQSRGEITSTAFPKKYVFTATTAQMCTMLLFNEQDSYTVEQIAAATKMDEKSAPAIVGSLIKNLVLKADTELQKEDEVPMTATVSLNKAYMNKKVRVDLSKFTMKQDAVRDTENVQKNVEEDRKSVISACIVRIMKTRKRVQHQQLMTEVITQLSGRFKPKVEMIKRCIGSLIEKEYMLRTEGQKDLYEYLA
What is the function of this protein?
Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.  As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.  Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway.
What are the official names of this protein?
Cullin-1, CUL-1, Abnormal cell lineage protein 19.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_THET8
Sequence: MKIVLAYSGGLDTSIILKWLKETYRAEVIAFTADIGQGEEVEEAREKALRTGASKAIALDLKEEFVRDFVFPMMRAGAVYEGYYLLGTSIARPLIAKHLVRIAEEEGAEAIAHGATGKGNDQVRFELTAYALKPDIKVIAPWREWSFQGRKEMIAYAEAHGIPVPVTQEKPYSMDANLLHISYEGGVLEDPWAEPPKGMFRMTQDPEEAPDAPEYVEVEFFEGDPVAVNGERLSPAALLQRLNEIGGRHGVGRVDIVENRFVGMKSRGVYETPGGTILYHARRAVESLTLDREVLHQRDMLSPKYAELVYYGFWYAPEREALQAYFDHVARSVTGVARLKLYKGNVYVVGRKAPKSLYRQDLVSFDEAGGYDQKDAEGFIKIQALRLRVRALVEREGHGA
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_BORBZ
Sequence: MFKVIKCNELNEKLIDKKVEINAWVKKIRHHGKFIFLNIRDRYEKAQVLVNEEKLLKIAEKIKLEYCIKIQGLLIKRPPNMINANMKTGHFEILAKNIEIISKCNELPFMIEDDNNASENSKLEYRYLDLRRDSLKNKIILRCQATHLIRNFLIKRKFLELETPTFVKSTPEGARDFVIPSRIHKGSFYALPQSPQLYKQLIMIAGFDKYFQIARCYRDEDSRGDRQPEFTQLDLEMSFVKKENIFKLIENMLFLIFKNCININLPKKFKKITYKKAMNKYGSDKPDTRFELELQDISRNLKNSEFNIFKDTLKNKGSIKILIVKDKADKFSRAKINNLEEIAKLYKTQGLYFTKIENNKFSGGIAKFLKTEEQELIKTYSLENNDIIFFTANNNWETACKAMGQIRIKIANDLGLIDENKFEFLWVYDFPLFEYDENTKTYSPAHHMFSLPKKQYIANLEKNPKKTIGEIYDLVLNGVELGSGSIRIHNKELQQRIFKIIGFQKEKSEDRFGFFLKALEYGAPNHGGIAIGIDRLIMLMTKSTSIKDVILFPKNSFAASPLDNSPSKISNEQLKELGINIVDGDN
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAY_SHISS
Sequence: MNDSEFHRLADQLWLTIEERLDDWDGDSDIDCEINGGVLTITFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWICDRSGETFWDLLEQAATQQAGETVSFR
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: FZD10_MOUSE
Sequence: MQHPGPRLWLVLQVMIGSCTAISSMDLERPGDGKCQPVEIPMCKDIGYNTTRMPNLMGHENQREAAIQLHEFAPLVEYGCHSHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFKFRWPDSLDCSKLPNKNDPNYLCMEAPNNGSDEPSRGSGMFPPLFRPQRPHSAQEHPLKDGGPGRAGCDNPGKFHHVEKSESCAPLCTPGVDVYWSRDDKRFAVVWLAIWSVLCFFSSAFTVLTFLIDPSRFRYPERPIIFLSMCYCVYSVGYIIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVFSLLYTVPATCVIACYFYERLNMDYWKMLATQHKCKMNNQTKTPDCLMTTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQHVCSRGLKRKSRRKPASVVTSAGIYKKAQHPQKPHLGKYELPAQPSACV
What is the function of this protein?
Receptor for Wnt proteins (PubMed:15923619).  Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619).  The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
What are the official names of this protein?
Frizzled-10, Fz-10.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ANR29_HUMAN
Sequence: MCRMSFKKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLRSKEGPRKS
What are the official names of this protein?
Ankyrin repeat domain-containing protein 29.
Protein: TTCA_POLAQ
Sequence: MGDIRKVVFEENKLEKKLCRLVGQAIGDFGMIEDGDKVMVCVSGGKDSYAMLDILMKLRERAPIDFEIVAVNLDQKQPNFPAETLPNYLRSLGIPFHIEEQDTYSIVKRVIPEGKTTCGLCSRLRRGILYRVADELGATKIALGHHRDDILETLMLNMFYAGKLKGMPPKLRSDDGKHIVIRPLAYVPEKLLERYAIDMNFPIIPCDLCGSQPNLQRQVMKEMLRDWEKKHPGRVENLFRSMHHIVPSHLMDGEAFDFKNLEISTELSGIAARSSGDRAIDEADLDELACGTMIQGTYNPSL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y741_BURTA
Sequence: MDARLLEILVCPVCKGPLHYDRGAQELVCNADKLAYPIRDGIPVMLVDEARQTVEGTPVDPAGPAQGR
What are the official names of this protein?
UPF0434 protein BTH_I0741.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: ATPF_SHEB8
Sequence: MNFNATLIGQTVAFIIFVWFCMKFVWPPLMNAIEERQKRIADGLADADRAVKDLELAQAKATDQLKEAKVTANEIIEQANKRKAQIVEEAKTEADAERAKIIAQGKAEIEAERNRVKEDLRKQVATLAIMGAEKILERSIDPAAHSDIVNKLVAEI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DNAA_XANC5
Sequence: MDAWPRCLERLEAEFPPEDVHTWLKPLQAEDRGDSIVLYAPNAFIVDQVRERYLPRIRELLAYFAGNGEVALAVGSRPRAPEPAPAAAAVPSAPQAAPMVPFAGNLDSHYTFANFVEGRSNQLGLAAAIQAAQRPGDRAHNPLLLYGSTGLGKTHLMFAAGNALRQANPAAKVMYLRSEQFFSAMIRALQDKAMDQFKRQFQQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGRQQIILTCDRYPREVEGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGAEIPDDVAFLIAKKMRSNVRDLEGALNTLVARANFTGRSITVEFAQETLRDLLRAQQQAIGIPNIQKTVADYYGLQMKDLLSKRRTRSLARPRQVAMALAKELTEHSLPEIGDAFAGRDHTTVLHACRQIRTLMEADGKLREDWEKLIRKLSE
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_SHESA
Sequence: MKQLLDFLPLIIFFAVYKFFDIYIASGALIAATALQLVVTYALYKKLEKMHLITFAMVTVFGTLTLVFHDDAFIKWKVTIIYALFALALGVSQLLNKSILKSMLGKEMKVADKIWAHVTWYWVSFFAICGLVNIYVAFRLPLETWVNFKVFGLTALTLINTVITVFYLYKHLPEDQRKELK
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MDH_NEOSM
Sequence: MKVSLIGAGNIGGTLAYLIASKKLASEVELIDVNGDLARGKALDVSQTLPLIGYTMKINGSANMERIKGSSVIIITAGIPRKPGMTREELIDVNAVVMKEVGEKIKKFAPKAFVIVVTNPLDVMVWVLYKAAEISPDKIVGMAGVLDASRMNLFLAQELGVSVADVKSLVLGSHGDSMVPLFRHSTVSGMSLPELVSVGLITKDKVDSIIERTRSGGAEIVALLKTGSAYYTPAASVLEMAEAYLLDQKKTLVCSVMMRGRYGVEDDIFSGIPVIMGSGGVERVIELDLTPDERRMFENSVAATRKLVLEARKYF
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: WASC2_MOUSE
Sequence: MNRTSPDSERPPASEPVWERPWSVEEIRRSSQNWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIQETKATHCRLHNVFNDFLMLSNTQFIENRVYDEEVEEQVLKAEAEKAEQEKTREQKEIDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANERVDLILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDSEDEKEEEESDEDFASHSDNDQNQHTTQISDEEEDDDGDLFADSEKEGDDIEDIEESAKSKRPTSFADELAARIKGDISNQRKEGQTDGKPQKTVKEKKERRTPADDEEDILFPPPTLTDEDFSPFGSRGGLFSNGQGLFDDEDESDLFKEAPRARPAQAPVSEELPPSPKPGKKIPAGAVSVLLGHPDVSGSTSAPSLKELQKHGQPTPGKSSHLPTPAGLFDDDDNDNDEDDNNFFMPSSSKPSKTDKVKSTAIIFDDDEGDLFKEKAEALPAASVSQTHESKTRADKTIALPSSKNLKLVSETKTQKGLFSDEEDSEDLFSSQSSSKPKSASLPSSQPPTSVSLFGDEDEEDSLFGSAAAKKQTSSLQPQSQEKAKPSEQPSKKTSALLFSSDEEDQWNIADSHTKLASDNKSKGELWDSGATQGQEAKAVKKTNLFEDDDDDEVDLFAIAKDSQKKTQRTSLLFEDDAESGSSLFGLPPTSVPSATTKKESVPKVPLLFSDEEDSEVPSGVKPEDLKVDNARVSPEVGSADVASIAQKEGLLPASDQEAGGPSDIFSSSSPLDKGAKGRTRTVLSLFDEDEDKVEDESSTCAPQDGREKGLKTDSRPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKIRSSVPSGGSLFGDDEDDDLFSSAKTQPVVPEKKGTLKKDHPVSLKNQDPLDSTQGSKEKSTWKTEPAQDSSGLTPFKSREPSSRIGKIQANLAINPAALLPTVALQIPGTKPVSSELAFPSSEPGRSHILESVPTLPGSVEAGVSFDLPAQADTLHSANKSRVKVRGKRRPQTRAARRLAAQESSEAEDVTVDRGPVAQLSSSPVLPNGHQPLLQPRMASGQTSSETATAPPWEGGPVLSAADRSFFVKSRPQTGNEADLFDSGDIFPKSRGSQSVEGAGVMAGEPPSHSSGGRKEKSLAFPDLSEGSSTEDLFQSVKPRAAKNRNPFPLLEDEEDLFADPRGKKNERKPDSHQDSVSKTHDIFEDDIFATEAIKPFPKKREKGRTLEPNLFDDNIDIFADLTVKPKEKSKKKVAAKSMFDDDTDDIFSSGLQAKASKPKSQSAEAASEQRSEHKVASIFDDPLNAFGSQ
What is the function of this protein?
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.  Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC.  Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission.  Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2).  Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1.  Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35.  Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L.
What are the official names of this protein?
WASH complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the FAM21 family.
What are the subcellular locations of this protein?
Early endosome membrane. Cell membrane.
Protein: NAGB_STAAW
Sequence: MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDNVSTFNLDEYVGLTASHPQSYHYYMDDMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDVLEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTESTIKANSRYFKNEDDVPKQAISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACPKNVAKIHVDEMD
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: RCDA_ECOLI
Sequence: MRRANDPQRREKIIQATLEAVKLYGIHAVTHRKIATLAGVPLGSMTYYFSGIDELLLEAFSSFTEIMSRQYQAFFSDVSDAPGACQAITDMIYSSQVATPDNMELMYQLYALASRKPLLKTVMQNWMQRSQQTLEQWFEPGTARALDAFIEGMTLHFVTDRKPLSREEILRMVERVAG
What is the function of this protein?
Regulates the expression of a number of genes involved in biofilm formation and stress response.  Target genes include six stress-response transcriptional regulators: csgD, which is a master regulator of biofilm formation, appY, sxy, ycgF, fimB and rcdA itself.  This indicates that a large number of genes must be regulated indirectly via these transcriptional regulators.  Acts by binding to the upstream region of its target genes.
What are the official names of this protein?
HTH-type transcriptional regulator RcdA, Regulator of csgD.
Protein: SECA_HELHP
Sequence: MLQTLISKFLGSRNNKLIKHYLKEVQAINALESTYNTLSDAQLQEAFMQLRKLIQNGETSLQSILHKSFAITREASKRVLGMRHFDVQLIGGMALNDGRIAEMKTGEGKTLVATLAVCLNALCGRGVHVVTVNDYLANRDAKELEPLYNFLGFEVGIITSEVRDDNERLQAYACDIVYGTNNEFGFDYLRDNMKYDLSQKVQGEHYFAIIDEVDSILIDEARTPLIISGPVNRTLEHYQLANSVAQRLKNEEDFSIDEKNRVILLNEEGIKKAESLFKVDNLYSIENAALSHHLDQALKANYLFIKDKDYVVQNDEVVIVDEFTGRLSEGRRFSEGLHQAIEAKEKVDIKEESQTLADITFQNYFRLYEKLSGMTGTAQTEASEFLQIYNLEVVSIPTNVPVQRKDLNDLIYKSEKEKFNAVIDKIQELYKKGQPVLVGTASIEKSEILHELLKKHRIPHTVLNAKQHTKEAEIIKDAGVKGAVTIATNMAGRGVDIKINDEIRELGGLYIIGTERHESRRIDNQLRGRAGRQGDPGISQFYLSLEDSLLRIFGSDKIKGIMERLGLKEGEHIESGLVTRSVESAQKKVENLHFESRKHLLEYDDVANEQRKAVYKLRNELLDENCSLQERISTNRELTAQSMLYKAQILPGDDSSNFNIDSLKAQINEELGLEIGNCENLDYDELLEKLITQMNTAYEEKMSKLEESQRAQIERIIYLQVLDSSWREHLYTMDNLKTGIGLRGYNQKDPLVEYKKESYNLFLEFVENLKFETTKMLQIIQLRDKEEEVANKMIKNLQDELEENLQDLNTNMDSTPVRKNKIARNDPCPCGSGKKYKVCHGKSGPKSGLLA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: PYRD_SHIBS
Sequence: MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PA2H2_BOTAS
Sequence: MRTLWIMAVLLVGVEGSLFELGKMILQETGKNPAKSYGAYGCNCGVLGRGKPKDATDRCCYVHKCCYKKLTGCNPKKDRYSYSWKDKTIVCGENNSCLKELCECDKAVAICLRENLNTYNKKYRYYLKPLCKKADAC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks enzymatic activity.  Is myotoxic and induces a dose-dependent edema in the mouse foot pad (PubMed:2781572, PubMed:9839670).  Also exhibits strong anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 3 nM) (PubMed:18062812).  In addition, it shows cytotoxic activity to a variety of cell types and bactericidal activity to a variety of Gram-negative and Gram-positive bacteria (PubMed:7886694, PubMed:9654096, PubMed:9920486).  Also induces a very rapid release of large amounts of potassium ions and ATP from muscle cells, which accounts for the pain reaction characteristic of viperid envenomations (PubMed:20660736).  The released ATP amplifies the effect of the myotoxins, acting as a 'danger signal', which spreads and causes further damage by acting on purinergic receptors (PubMed:20660736).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog 2, svPLA2 homolog, Myotoxin II, Basp-II, Lys49 Mt-II, MtxII.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS9_CAMLR
Sequence: MATTYATGKRKTAVAKVWVKSGSGKIIVNGMDLNTWLGGHEAIKLKVVQPLLVTKQETSMDIKATTLGGGYSAQAEALRHGISRALASMDADFRALLKPKGLLTRDSRTVERKKYGRRKARRSPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: SSRP_HELP2
Sequence: MKLIASNKKAYFDYEILETLEAGLALLGSEVKALRQTRVNLKDNFVKIIKGEAFLFGVHISYLDTIHAYYKPNERRERKLLLHKKQLLKWQIEASKERLSIVGLKLYFNQRNRAKIQIALVKGKRLHDKRQSLKEKALNKEILADLKHHFKG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SPEE_BUCAT
Sequence: MDHKKTWHEKLYCHLGQYFLIEKMLYKKKTPHHQVMIFKNSVFGKIMVIDDIVQTTERDEFIYHEMLTHVPIIAHGSIKSVLIIGGGDGGILREVCRYKMIENITMVEIDVNIIDLCKKYFPNHSNQAYQDSRLNLIIDDGLNFIKRTKEKFDLIISDSTDPIGCGKNLFRSEFYFNCKNHLEENGIFVAQNGVFFLQKNETILTYKNLKKYFYDTRFYQANVPTYYGGVMVFAWGTNNIEYRKNSLEKIQIRIKNTKLDFNYYNAKIHISSFYLPQYILNELNES
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_PARMW
Sequence: MSQPRIGQKVVVDVPATTANLGPGFDCLGAALDLNNRFAMRRIEGSGERFELIIEGTYGSHLRGGPDNLVYRAAQRVWKAANMEPVALEARVRLAVPPARGLGSSATAIVAGLMGANALVGEPLSKEKLLELAIDIEGHPDNVVPSLLGGLCMTAKAASQRWRVVRCEWISSVKAVVAIPSIRLSTSEARRAMPKAIPVSDAVVNLGALTLLLQGLRTGNGDLIADGMHDRLHEPYRWRLIKGGDDVKAAALEAGAWGCAISGAGPSIIALCAEDKGQAVSRAMVKAWEAAGVASRAPVLNLQTSGSHWQPADAG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSLBA_MOUSE
Sequence: MRPLTMSGHFLLAPIPESSSDYLLPKDIKLAVLGAGCVGKSAMIVRFLTKRFIGDYEPNTGKLYSRLVYVEGDQLSLQIQDTPGGIQAQDSLSQMVDSLTKSVHWAEGFLLVYSITDYESYQSIRPLYQHIRKVHPDGKAPIFIVGNKGDLLHARQVQTHEGLQLANELGSLFLEISTSENYEDVCDVFQHLCKEVIKVHRLGGERRRASVIPRPRSPNMQDLKRRFRQALSSKAKASSALG
What is the function of this protein?
Regulator of rDNA transcription.  Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription.
What are the official names of this protein?
Ras-like protein family member 11A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Associates with rDNA transcription unit throughout the cell cycle.