Protein: CGHG_CHAGB
Sequence: MSAADQEPIAVIGMACRFPGGSNSPSKLWELLKAPHDIAKPIPDDRFDSTGFFHKNGSHHGATDCREAYFLDEDVTRFDNAFFNVQPGEAEALDPQQRFLMETIYDSLCSAGQTIEGLRGSRAAVYVGLMCDDWSQMNGRDWDLVPTYAATGTSRAVVSNRVSYFFDWHGPSMTIDTACSSSLVAVHEGVNALRRGESPIVVAAGANMILSPGMMIAESNLHMLSPTGRSKMWDASADGYARGEGIAAVVLKPLSAALRDGDPINCVIRGTGVNQDGRTPGLTMPNNVAQADLIRDTYERAGLNIQDPKDRPQFFHAHGTGTPAGDPQEAEAISRAFYEGGSVKDPLFVGSIKTVIGHTEGTAGLASLIGTALAMQNNTIPPNLHFNTLSPRVAEFCDNLRIPTKALPWPTPVAGQPRRASVNSFGFGGTNAHAIIESYEAAPTEQRTVSTKVPAFTPLTISAASASALRTTLSDLSAYVLSHPDTDLRDLAYTFQHRRSTLAFRKAIATDNRDALVGTIDALLNEGGAGDGGLTARYFDSPDPKILGVFTGQGAQWPRMGALLLEQSPYVGELLTQLDQALATLPEGDRPDWTLREQILAEAAQSRLSEAAISQPLCTAVQIALVDLLGLAGIRLRGVVGHSSGEIAAAYASGYLSATDAIRVAYYRGLYAKLAGSPAGRGSMLAVGTSFEDAVEFCELEEFEGRIKVAARNSSNSVTLSGDEDAIEEALEIYKDEGRFARQLRVDTAYHSHHMEPCAVPYRDALTRCEIKVGEGNGIPWYSSVIEGHVMAPTDVSPQYWVDNMTSAVLFSPAVAHAVAEGGPFDLGVEVGPHPALKGPCLDTVEEAAGHRIPYTGLLGRNKNDVVELSSALGFIWTQLGAASVDFDRLERAISGNPYPKKVVDDLPTYPFDHSRSFYTLTRFSGAHRNMHAPPNPILGRRCVETETADEVSWRNILKSGEISWLQGHQLQGQTVFPAMGYIAMCVEAAAVLAGPERPLGLVTLEDVIIGRALAFQNESVGMESKVTVKIDHTSDDELRGHIACHSGLPFDSAAPLALNFSATLHVRFHEPRADTLPAVRADEISLVKTDPGRLYSQFTQLGYNYSPPFTGVKAIQRKRGFATGDIEDISGEGWEDQLIVHPGWLDSALQTAFAAYSYPHDNRLWALHVPTEIRTVSINPYFTERGAGGRTRQLQYQSTAREGLGAPVAADIDVFAAGEEDGHAFIQLEAVQVKPFAAATARDDALLFARFDYRLANPDAIAAVEGDDLLPPKTEAVVETIERVGFYYLRRVHETVTPAERRPTLPHFRHLIDLCGRVVPLVAAGEHPHVPREAINDSASYIRSLIARYHDRADIQLLEAVGENLVGEIRRNGIMLEHMMKDGILDRFYEELAGLDVANVWIARMVAQVAHRHPHLRILEIGAGTGGTTRTVLPMLGDAFQSYTFTDISAGFFGSAQERFRTYADRMVFATYNMELTPEEQGFEEGTYDVVLASNVLHATGRLDDMMANTRRLLRPGGYLMMLEFVSNDRTGITACMGGLPGWWGNGIVDPARGDGPCLTPAQWDELVRRHGFSGVDTHCPVEKHLQWYTVHLCQAVDDRVLALRNPLESLESAATLAPPPAELVIVGGTTATVSKLIDEASTLLAPRYNTISRVATLEELDQRGLPLGSSVLSLTELDHQFFEHRTAAKLEALKALWRAGGSIIWATRGVRDASPYSAMILGLARVVRFEYPNINLQILDFDRAPDAATLAADLVRLEMGRHWKEEGANILYSVEPEAHYENGALFIPRMYPDRDANARYNTQRRTVAREVDPRETSVVLEPAGPVGGALELCAPSPLRVAPAARPGAEKTVEVIVEQSVLHAVKVPDAGFFSLCAGTDAETGRPLLALVDSPVESRLRVPVEWTVSLREPLSRTGAFSLGDVASHLVASAILAGAPAFGSLLIHEADESLKEAFGRQAAGHGAHVVFTTADKAKARAGADWVLVHEKLPGRLVQRLLPHDISSFTDLSHSEGSASAQLIVHSLPVYSPITTVKDVIRAQAGAFPDAAPQDVGAALKAAWQAASRKRKGSGNKSQTSAIPVLPLQDVSRAGARHAPLTVVDWNTNSVSVALRPIDAGTIFRSDGTYFLVGLSGEVGQSLCQWMVAHGARHIVLSSRRPKVHPRYIEDLAALGATVRVMALDITNREALRACYDTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAVVQDSLTENLIRILMMPATETVDPMMSLVELGIDSIMAVDLRTWFLKELDVDVPVLKILSPGETVKSLAEEAMAKIPAEIVDLSKLAEGSADVSGAPAPAAVQPVQPAPVPVPVPVTKKAIDQVSEASGVSATTPSTRAETDASSSPALVSTPGTSLERPDQEEDKQLFQPPPRPKPTTLQHRLPRQAYWAGSASTTSPKPSRRAAQRHETLRTRFFWSTDDSRTPMQGILSQTLVRLETATIETEAQASEELEAMRKYEWNLGDWVPLRIKLLTLSETSHYLILGSHHISMDGHSFSVFLLDIHQAYNNPARPLPPMPSTSQARAFGAHQIAAYESGQMRPAIEHYKTTLPAADLARPIELFPFARTKVRPPLDRYGTHVARAHLGPDTTAKLKTLARGRRATSFHAYLGALQALLFRLLPADTTERVYIGIADANRLDSRFAASVGNFLNVLPLRFDRDAATFGQAIETARDKARDALKHSALPFDLLLDEVGVPRSPTLLIRCIVFMNYRLVVKEHADKQWIGCRIGEERWHTARTGYDVALEIVEDHDGATLAMHVQQSLYDADAAELLVRSFANAVKEFAAKGDAMETEKLQKWDKVDVEKALEIGTGPALNLKWPATVAHRIDEVIAQNPTAVALKDGLGNVLTYAQMDARVESIANALNVRLPNNADGKAPVVGVFQAPSADWICSLVAIHRVGAVYLPLDLRNSIPRLKSNVAVARPAALLVDAETASRVGELEIKDAVPAIDVSRLAADTKGKKPTNTAAARADQPAYIIFTSGSTGEPKGIVVTHAGLRNNLEGYHNAWNIPSLAGVVLQQVSFGFDALSASDLCLRXXXXXXXXXXLMVDHGVTMTQATPSEYEMWLRFAPDQLRRCTSWKAAWFGGERAAPGLVRSFRDLCVALPNLNVYTSYGPTESTISAMKGVADVRNDPTLTVPVPGRLLPNYTAYLVDDEMRPLPIGVPGEILLGGAGVGKNEYLGRPDLTTQAFLSSPFPVPGDGGKPARLYRTGDYGRLDKSGFLAIEGRIAGDTQVKLRGFRIELAEIERVMLRESDGQLAQVVVTARGVDDGEAEGFLAAHVVLESQSTDAAATAQVINRLRSRLPLSLPQYMCPAIIVPLAKLPLTSNDKVDRRAVQALSLPKTTTASTTADGTQPAQPLTPTESRLATLWAGVLPQRGGGVLQPRSDFFTAGGNSLLLVKLQAAIKREFGDAPRLSKLMSATELGSMAALLDQAGATALDWERETALDLPQGVTAPAKARENGAGLRVLVTGASGSLGKRIVRRLVGDNRVATVVCLVRPTEGRDPSTLFFAAGQADNAKIRTILADLPTIPTTHPDLDPAIIDAVIHCAADRSFWDGYSAVSLSTSTRSRPRCSLLTAGAHLHALSSGALGAFEDPNTYNTKSTLPRPSPTDGYLASKWVAERYLARAVREAGLRATAHRPSGAVPASEREGKEVLAAMAGDMLRLSASLGVRPDYARLSGSFDVGRLEDVAAAVVGEVTGGLGGQGGEEGMGVVEYPGMASVQIRELAEYAEMLLKNGGAEAEAVKGLPMVPALHWVGLAKRAGLFEWLLTAQHLVVDDEEGRKIVSRR
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of the tetramic acid Sch210972, a potential anti-HIV fungal natural product that contains a decalin core (PubMed:26360642).  The PKS module of cghG together with the enoylreductase cghC catalyze the formation of the polyketide unit which is then conjugated to 4-hydroxyl-4-methyl glutamate (HMG) by the condensation domain of the cghG NRPS module (PubMed:26360642).  One unique structural feature of Sch210972 is the tetramic acid motif proposed to be derived from the non-proteinogenic amino acid HMG, by a Dieckmann-type condensation catalyzed by the reductase domain of cghG (PubMed:26360642).  The aldolase cghB catalyzes the aldol condensation of 2 molecules of pyruvic acid to yield the intermediate 4-hydroxyl-4-methyl-2-oxoglutarate (HMOG), which can then be stereoselectively transaminated by an unidentified enzyme to form HMG (PubMed:26360642).  The Diels-Alderase cghA then uses the Dieckmann product released by cghG as substrate and catalyzes the Diels-Alder cycloaddition to form the decalin ring of Sch210972 (PubMed:26360642).  CghA also suppresses the nonenzymatic formation of the alternative stereoisomer (PubMed:26360642).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase cghG, PKS-NRPS cghG, Sch210972 biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.