PharMolix/UniProtQA huggingface dataset:
Protein: UPP_NEIMB
Sequence: MNVNVINHPLVRHKLTLMREADCSTYKFRTLATELARLMAYEASRDFEIEKYLIDGWCGQIEGDRIKGKTLTVVPILRAGLGMLDGVLDLIPTAKISVVGLQRDEETLKPISYFEKFVDSMDERPALIIDPMLATGGSMVATIDLLKAKGCKNIKALVLVAAPEGVKAVNDAHPDVTIYTAALDSHLNENGYIIPGLGDAGDKIFGTR
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: COBS_PYRAB
Sequence: MRNILPFLTRIPVKGDFEKARNELWAFPLVSLVSSIIPIAILYLRIPLANVLALLSLYFVIGLLHLDGLADWADGIMVKGDRERKIKAMKDLNTGIAGVFAVVVVLFLQVYSLSMLPFYAIYIAELNSKFSMLLGLATKKPLGQGLGAYFMEGMNGRQLAIGVVLYVLLYLPVVIYDPSALFGVMGLVFAWYVIRLSLENFGGINGDCLGAMAEITRAGTLVILSFSLCFTT
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AVIL_MOUSE
Sequence: MSLSSAFRAVSNDPRIITWRIEKMELALVPLSAHGNFYEGDCYIVLSTRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIQATEVEMSWDSFNRGDVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPGLMTVLQDTLGRRSMIKPAVSDEIMDQQQKSSIMLYHVSDTAGQLSVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTTGLGKIFSTGKIAKIFQDKFDVSLLHTKPEVAAQERMVDDGKGQVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPHYILYIWQGRHASRDELAASAYRAVEVDQQFDGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNEEPDPPVRLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELVDLLCDGNADTVAEGQEPPEFWDLLGGKTAYANDKRLQQETLDVQVRLFECSNKTGRFLVTEVTDFTQEDLSPGDVMLLDTWDQVFLWIGAEANATEKKGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITADMKNATLYLNPSDGEPKYYPVEVLLKGQNQELPEDVDPAKKENYLSEQDFVSVFGITRGQFTALPGWKQLQLKKERGLF
What is the function of this protein?
Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling.  May have a unique function in the morphogenesis of neuronal cells which form ganglia.  Required for SREC1-mediated regulation of neurite-like outgrowth.  Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates.  Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast.  Plays a role in ciliogenesis (PubMed:15247299, PubMed:18160648).  In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (By similarity).
What are the official names of this protein?
Advillin, Actin-binding protein DOC6, p92.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell junction, focal adhesion. Cell projection, neuron projection. Cell projection, axon. Note=In podocytes, present in the F- actin-enriched cell periphery that generates lamellipodia and focal adhesions.
Protein: RECA_BARHE
Sequence: MDKIKALDAALSQIERSFGKGSIMRLGQKEQVVEIETIPTGSLSLDIALGVGGLPKGRIVEIYGPESSGKTTLALHAIAEAQKNGGVCAFIDAEHALDPIYARKLGVDLENLFISQPDTGEQALEITETLVRSGAVDVLVVDSVAALTPRAEIDGEMGDALPGLQARLMSKALRKLTASIFRSNCMVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGSIKDRDMIVGNQTRVKVVKNKLAPPFKQVEFDIIYGEGISKLGELIDLGVKVGTVEKSGSWFSYNSQRLGQGRENAKQFLREHPEIATEIETALRQNAGLIAIELLENAGSENTESDEVI
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPMA_HAEIN
Sequence: MTALNHWQPSADIKNHLKRAKIIAKIRQFFTERGLLEVETPVLSEFGVTDLHLSTFSTEFLAPFGEQSKTLWLSTSPEYHMKRLLAAGSGPIFQISKVFRNEEAGNRHNPEFTMLEWYRPHFHMHRLINEVDDLLQQILDCPPAESLSYQFVFQEYVGLDPLSAERSELIEAARKHNFMAEDNEDRDTLLQFLFSEVVEPQIGKERPIAVYHFPSTQAALAQVSPEDQRVAERFEFYYKGLELANGFHELADAQEQRHRFELDNQQRQKCELPTREIDERFLAALEAGMPDASGVALGIDRLMMIALDCEKINDVISFAVDNA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P).  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: RDRP_I93A0
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEIEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPEWFRNILSIAPIMFSNKMARLGKGYMFESKRMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFSEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: RNH2_MYCGI
Sequence: MPAVWPPRTVIRKSSGLRTLESALYRAGLGPVAGVDEVGRGACAGPLVVAACILGPNRLESLSALDDSKKLNESERERLFPLIRRYAVAFHVVFIPSVEVDRRGVHVANIEGMRRAVAGLAVRPGYVLSDGFRVPGLPMPSLPVVGGDAAAACIAAASVLAKVSRDRLMVAMDQEHPGYGFADHKGYSTRAHSAALNDLGPSTQHRFSFINVRRLVVDGEPGQGGELECGKLAVDVPVDMPVDRVLREGQLSR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNCB_METAC
Sequence: MIKSILDNDLYKFTMQMAVLELFPKAEAEYRFTNRGSHHFSEEFVEKLRRVIDEDISALMLTEDEYQWLGENCSFLKPMYLEYLKNFRFKPGEVEVCLTEEKELDIRIKGPWHSTILWEIVLMAAVSELYFTTIEKEWNGKEWDGNISATSESILTAYGEKILEIGKILEENGCLFAEFGTRRRRSFELHDQVMKTLLQIETLTGTSNVFFAKKYGLKPIGTVGHEWIMGTSALIGLRYANRFAFENWVEVYKGDLGIALTDTFGSEAFFKDMDLKLSKIYDGFRHDSGDPFTFVDRVIDHYRKMGIDPMKKVIVFSDALNAEAAIRLKKYCQDKINCSFGIGTSLTNNSEFFRESPPLNMVIKLHSVNGIPVVKLSDSPEKETGERDALRVANYIVGRKGLDE
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: 36016_ASFP4
Sequence: MLSLQTIAKMAVATNTYSKCHYPILKVFGLWWKNNTLNGPIKICNHCNNIMVGEYPMCYNHGMSLDIALIRAVKERNMSLVQLFTEWGGNIDYGALCANTPSMQRLCESLGAKPPKGRMYMDTLIHFSDTLNDNDLIRGYEIFDDNSVLDCVNLIRLKIMLTLKARISLMEQLDQIALKQLLQRYWYAMAVQHNLTIAIHYFDNHIPNIKPFSLRCALYFNDPFKIHDACRTVNMDPNEMMNIACQQDLNFQSIYYCYLLGADINQAMLMSLKYGHLSNMWFCIDLGADAFKEAGVLAGKKNRRVLQYILGLNIFKRELIPPCKDPDPYQIQILLKNYILKNVSTVFTYYCQ
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-16R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: CYSD_PSEA8
Sequence: MVDKLTHLKQLEAESIHIIREVAAEFDNPVMLYSIGKDSAVMLHLARKAFFPGKLPFPVMHVDTRWKFQEMYRFRDRMVEEMGLDLITHVNPDGVAQGINPFTHGSAKHTDVMKTEGLKQALDKYGFDAAFGGARRDEEKSRAKERVYSFRDSKHRWDPKNQRPELWNIYNGKVKKGESIRVFPLSNWTELDIWQYIYLEGIPIVPLYFAAEREVIEKNGTLIMIDDERILEHLSDEEKARIEKRMVRFRTLGCYPLTGAVESSATTLPEIIQEMLLTRTSERQGRVIDHDQAGSMEEKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: RTN1_XENTR
Sequence: MAANPEVFSGRLEGNVAAARRPGSAQEEEGEAAGGALSCVDQGRTIKAEQAGHPTVAMEITSTDFTSTLHLHDAESKELPGDENGLSYTYLSSDKHSHTDSTYFTGISKKGTESPDIKEFSGVGPRSPKEIPTFDSRGLLSSDSGIEMTPAECSEVNKSLADPTEEEKQEAYKYIDISRSPDMKPQQVLDKDFGENKASTIGQAAPTEQQAYDSVTMSWQKDHYNGNISEYLPYVPYMEEPRKDFGLYNSPTSKEPKSAPVTISFTGMETTLQTEYPENQQGKSDKGLKLSPDMVPTVTVSEPEDNSPESITPPSTDADGYTEPSGLEEQRKYKISEDELISAIKAKEGTKGFSSETNEEKQSYSFNVEKQDFTVLPTRDAPAPLDMEGSSTESGDSEIELVSEDQVGAEEAMQSAYMTFSHIGGPPPSPASPSIQYSILREEREAELDSELIIESCDGSSASEESPKRDQDSPMMKPMIMDIIEEENLSRAESFDASDFESCSLKERKLNMENLAESACYLKGTYHTEIRADMPSTKKEELLPQKKSPEGSAYQSKVLGKTSTLPLKPLPFLSKRKAIELLYWRDIKQTGIVFGSVLLMLFSLTQFSVVSVIAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKSYLDMEISLSQEQIQKYTDCLQAYTNSIVKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLIMAVVSMFSLPVVYDKYQAQIDQYLGLVRTNMNTIVTKIQAKIPGTKQKE
What is the function of this protein?
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
What are the official names of this protein?
Reticulon-1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus. Note=Mainly localized to the endoplasmic reticulum with some expression in the nucleus and polysome fractions.
Protein: RSAD1_DANRE
Sequence: MSTRVLTLTLLKKRHLMQCFWSTVGSVHLRSIASDKIPSHAVEASLYVHWPYCLKRCSYCNFNKYISRSENHDTMTECLQKETETLLKLSQVSRITSVFFGGGTPSLAQPSTIAAVLETVTKNSNLSDLAEVTLEVNPTPAGKARLKDFTLAGVNRFSIGVQSLNADHLRILGRDHSVQHALQTVSEARKLCPGRVSVDIMFALPGQSVSCWQKQLEELLYVCDDHISLYQLTLERGTQLFKQVESGKLSVPGDEVTAIMYKTACRVLEESGFHQYEVSNFARNNAVSEHNMGYWRGHQYIGVGPGAHGRFVPHGDGGVQREARTQTLEPDVWIKEVQSRGRGTRRRITLHHLQLLEEVLVMGLRMNEGITHQHWELFSPEANLQQVFGKSANIQELQGGRFLILDDRGLRCSWEGLVLLDSILPTILLELEMFFHSRGIKRTQ
What is the function of this protein?
May be a heme chaperone, appears to bind heme.  Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (By similarity).  Binds 1 [4Fe-4S] cluster.  The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).
What are the official names of this protein?
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial, Putative heme chaperone.
What is the protein family that this protein belongs to?
Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DEF_SALHS
Sequence: MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGNPFELEADGLLAICIQHEMDHLVGKLFIDYLSPLKQQRIRQKVEKLDRLNARA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: TMC47_THAMA
Sequence: KASSSAPKGWTHHGSRFTFHRGSM
What is the function of this protein?
Able to depolarize frog skeletal muscle fibers, but has no effects on squid giant axons.  Tetrodotoxin is able to partially antagonize the depolarization.  Induces myonecrosis.
What are the official names of this protein?
Myotoxin TmC4-47.2.
What is the protein family that this protein belongs to?
Belongs to the true venom lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CCDB1_PONAB
Sequence: MASATAPAAAVPTLASPLGQLRHLAEELRLLLPRVRVGEAQETTEEFNREMFWRRLNEAAVTVSREATTLTTVFSQLPLPSAQETQKFCEQVHAAIKAFIAVYYLLPKDQGITLRKLVRGATLDIVDGMAQLMEVLSITPTQSPENNELISYNSVWVACQQMPHIPRDNKAAALLMLTKNVDFVKDAHEEMERAVEECDPYSGLLNDTEENNSDNHNDEDDVLGFPSNQDLYWSEDDQELIIPCLALVRASKACLKKIRILVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMCHLTVRINSAKLVSVLKKALEITKASHVTPQPEDSWIPLLINAIDHCMNRIKELTQSELEL
What is the function of this protein?
May negatively regulate cell cycle progression.  May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity).
What are the official names of this protein?
Cyclin-D1-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the CCNDBP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SPRTL_BACC1
Sequence: MDEQEIQRLVEEVSLQYFGMPFLHKALFNSRLRTTGGRYLLNTHNIELNYRYYEMYGKEELVGIVKHELCHYHLHITGRGYKHRDKDFRELLKAVDAPRFCKRMMNEEKEKKVYMYECMGCSLQYVRRRQINTKRYVCGKCKGKLILIKKTS
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLK3_MOUSE
Sequence: MEPAAGFLSPRPFPRAAVPSAPPAGPGPPANASPRSEPEVLAGPRAPDPPGRLITDPLSGRTYTKGRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLPVSSCVTVPDLTPPNPARSLFAKVTKSLFGRKKNKNKNHSEDQDNVSCLAPVVSGQAPASLIETAAEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCVAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSMGSVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEAEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDQSPA
What is the function of this protein?
Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly.  Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains.  Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1.  Involved in cell cycle regulation: required for entry into S phase and cytokinesis.  Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis.  Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia.  Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73.  Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis.  Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint.  Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions.  Phosphorylates HIF1A and JUN is response to hypoxia.  Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium.  Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1.  May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.
What are the official names of this protein?
Serine/threonine-protein kinase PLK3, Cytokine-inducible serine/threonine-protein kinase, FGF-inducible kinase, Polo-like kinase 3, PLK-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase (By similarity).
Protein: RS19_ECO5E
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPLRTWSRRSTIFPNMIGLTIAVHNGRQHVPVFVTDEMVGHKLGEFAPTRTYRGHAADKKAKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: Y3312_MYCBO
Sequence: MTAPASLPAPLAEVVSDFAEVQGQDKLRLLLEFANELPALPSHLAESAMEPVPECQSPLFLHVDASDPNRVRLHFSAPAEAPTTRGFASILAAGLDEQPAADILAVPEDFYTELGLAALISPLRLRGMSAMLARIKRRLREAD
What are the official names of this protein?
Uncharacterized SufE-like protein Mb3312.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
Protein: PYR1_ASPFU
Sequence: MEPHGETDLVSFAFSSPTPFDPTRPIYLDAQNPSRAFNARQFRLLVRSLIAGLRALGLKPGHCVLVQLENTVIHSALFFAIVGAGGVYMGCDVGSPAHELTHLLRLAEPQLVITAPGALSTLEVCSTQGESFSGQVLLVDELSIDNIVQFAHRAAAAGAEAQTEGLVDQTAGPCIRLESLLQHGESDWLRFEDREQSKRTPAAMFLTSGTSGLPKAAISTHHTIISHHLSVHYRVPYPVVRLMALPMYHSFGDFWTNIFPIRYGEPLYVLPRFDISTFLDAVRQHHISETYMVPAMVQILSQSSLPVAESLASLRYVGISGAPIDGFSIQRFQRLLSPDAVAGNLWGMTEVGVVFQNRYRVPLQFGSVGTLLHGYELRFVDPATGEDVAGTPDSPGELYVRGPGLLLGYKWRTDDKDEQGWFRTGDMVYARDGNYYIIGRTKDLIKVRGQVPDSLNSWTSHSTNRLCDSRYSVAPAEIEGILLKDPGVKDAAVIGVMLPDGSSEVPRAYVVRAGISPESTADQLTDLVQTQLASYKALDGGVVFVDEIPRTGIGKPHRARLSQLDREREKLASILGVSVPA
What is the function of this protein?
Nicotinic acid-CoA ligase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl-coenzyme A:cholesterol acyltransferase 2 inhibitor (PubMed:20861902).  The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1 (PubMed:20861902).  Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO (PubMed:20861902).  The next steps consist of an epoxidation of farnesyl-HPPO to epoxyfarnesyl-HPPO by FAD-dependent monooxygenase pyr5 and a cyclization of the terpenoid portion by the terpene cyclase pyr4 to yield deacetyl-pyripyropene E (PubMed:20861902).  The 2 cytochrome P450 monooxygenases pyr3 and pyr9, and the 2 acetyltransferases pyr7 and pyr8 are involved in the conversion of deacetyl-pyripyropene E into pyripyropene A through several cycles of oxidation and acetylation steps (PubMed:20861902).  Pyr7 acetylates deacetyl-pyripyropene E to pyripyropene E which is oxidized to 11-deacetyl-pyripyropene O by pyr3, which is in turn acetylated into pyripyropene O by pyr8 (PubMed:21224862, PubMed:26019565).  Pyripyropene O is then oxidized to deacetyl-pyripyropene A by pyr9 (PubMed:21224862).  Deacetyl-pyripyropene A is finally acetylated to pyripyropene A by pyr8 (PubMed:26019565).
What are the official names of this protein?
Nicotinic acid-CoA ligase pyr1, Pyripyropene synthesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: NU4LM_MONPE
Sequence: MNLSIFLFLIGILGFILNRKNIILMIIAIEIMLLAVTLLVLISSFGFDDNVGQTFSLYIISIAGAESVIGLSILVAFYRLFLVLNYL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FA13C_MOUSE
Sequence: MFSCFCFSLQDNSFGSAAVTECDEDTVSVHEDEDDCSGLRDEDNKENYPQVAARLDELALPSHEAQQHVEQTLPVDGVLRTSMGNFKSRKPKSILRAESGRNHGESQETEHVVPSQSECQGRAGTPAHESPQSSIFRCQETVRLQPRIDQRATIWPKDAFGTQQDLHENSLLKLQALESGLCSAFLTTQEEDGQVHGVKDPAPASTQSAPADSADPADPMPAHKDAPGDADGTSEDLQSAGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSPPSSQQFMMPRSSSRCGSGDGKEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSTPKGPRRNLSCEQPPVPRENGKSEAVGPEPGSSGEETSDAVVPEKREQTPPQDDGKGTKQDKNLIKPLYDRCRGIKQILPTPSLIPTIQEEEDSDEDCPQGSQQPSLPDPVSRLPVGDHLIYSETEPVRTLLPDEKKEGKQPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFFKQTGRSPQKEDRMPMADEYCEYKHIKAKLRLLEVLISKQDVAKTI
What are the official names of this protein?
Protein FAM13C.
What is the protein family that this protein belongs to?
Belongs to the FAM13 family.
Protein: CLP5_ARATH
Sequence: MFGPQIRRVKLEKQSELRIELQPTSPLRLRLLDGKAEIFGYELPHEVWITFPPLMTFAVFTWYGATIEIDGITGNEYISCETPMVNYLGLHNSLQVQRHRVTSSTRDSASSQEGPRVIIVGDIDSGKSTLAKMLLNWAVKDGWKPTFVDLNVGQSSITIPGTIAAAPIKMLVDPVEGFPLDKALIHYFGLTNPSVNLRLYRTLVEELARELKEEFSANAESRASGMVIDTMGFIVREGYALLLHAIRTFNASLVIVVGQEEKLVYDLKKNLKFKKNLQVLNLEKSEGVFSRSSDFRKTLRNSNIQNYFYGVTNDLTVYTKTVKFSDVQVYRIGDFRVSGSTSAHQRGNDPLKITLVTIDEHLVNKVLAISYAIKPDQIISSIVAGFVCIKNVDISEERITYVSPSAAELPSKILILGTLTWHVT
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
Protein CLP1 homolog 5, CLP-like protein 5, Protein CLP-SIMILAR PROTEIN 5.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: WASC3_SALSA
Sequence: MDEDGLPIVGSGIDLTKVPAIQQRRVVAYLNQFIVHTVRFLNRFSTVCEEKLASISLRIQQIETTLSILEAKLSSIPGLEDVRVEGVGQLPATEVNGPVTVVVPSQPETPIAVAVPLPPPEASPNIPDPRAAEAAGDGRMTVAKDPRYARYLKMVQVGVPVMAIKNKMVQEGLDPNLLDTPDAPVPDAVKKNTLDQDDDSDDGSESSFSD
What are the official names of this protein?
WASH complex subunit 3, Coiled-coil domain-containing protein 53.
What is the protein family that this protein belongs to?
Belongs to the CCDC53 family.