PharMolix/UniProtQA huggingface dataset:
Protein: ALMA1_EMIHU
Sequence: MGNCTSHPHHEPQVHFDTVDGMATVKAFAGIRQVTMGVLRIDYEYQTNLGDILDPRSFDFRIISATAEGLTFAKAKAGDKLDATGKELLERAVRQLIDNGADFIVGDCGFLVYWQVMVRDYAQDYAQKKYGRKCPVMMSSLVLALPLLATIPSGGQIGILTASEKSLQAVQKKLPIVIEDHQKEDGGQRSRSVPAAEDPSGIMINFSDPRFKVVGLDEVKDFKHALDAQGADAVNDRRDIAVQIAAYCQKVQEKNPQIAAWLIECTEAGGFAWAIKVGTGLPVWDPITLGRFLSLGFTANVPNVALTLGQHGENPLDPSATTAGKGRCTGEEPGQIHALGAEFQAIREGTL
What is the function of this protein?
Mediates cleavage of dimethylsulfonioproprionate (DMSP) into dimethyl sulfide (DMS) and acrylate.  DMS is the principal form by which sulfur is transported from oceans to the atmosphere and is a key component of the ocean sulfur cycle.  Constitutes by far the most highly expressed Alma gene in CCMP373 strain.
What are the official names of this protein?
Dimethylsulfonioproprionate lyase 1, DMSP lyase 1, Dimethylpropiothetin dethiomethylase 1.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family. ALMA1 subfamily.
Protein: CVP3_PIMHY
Sequence: MRKPITLILVVALALVLLATSEVSAYRACGFPGRRCSPTEECCEGLVCQPRKNGPSMCYRPDP
What are the official names of this protein?
Cysteine-rich venom protein 3, cvp3.
Protein: AGUB_SOLTU
Sequence: MAEKNRLVTVAALQFACTDDVSTNVATAERLVRAAHQKGANIILIQELFEGYYFCQAQKEEFFHRAKPYLGHPTIVRMQNLAKELGVVIPVSFFEEANNAHYNSVAIIDADGTDLGLYRKSHIPDGPGYQEKFYFNPGDTGFKVFQTKYAKIGVAICWDQWFPEAARAMALQGAEVLFYPTAIGSEPQDDGLDSRDHWRRVMQGHAGANVVPLVASNRIGKEIIETEHGNSEITFYGYSFIAGPTGELVAAAGDKEEAVLVAQFDLDKIKSKRHGWGVYRDRRPDLYKVLLTLDGSNPVK
What is the function of this protein?
Involved in polyamine biosynthesis.
What are the official names of this protein?
N-carbamoylputrescine amidase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily.
Protein: KUP_AZOSB
Sequence: MQVEHEVATEGGQAPASSGHRKGIAGLAVAAIGVVYGDIGTSPLYTLKEVFNGPHAVPVNEANVYGILSLVFWALVTVVSAKYVVFITRADNRGEGGIMALTSLALRVVQPGRRAWWLSVLGVFGAALFYGDGMITPAISVLSAVEGLEVATPAFKPFVIPIALVVLVGLFVMQRRGTGSVGAIFGPVMVCWFLVLAVLGINGITLHPEIIGALDPRWAARFFIDQPLIGWLALGAVVLAITGGEALYADMGHFGRRPIKLAWFSLVFPALYLNYLGQGALILDHPDNVRNPFYMLVPDALVYPMVGMATLATIIASQAVISGAFSLTRQAIQLGYAPRMQTLHTSEHEIGQIYVPGVNWMLLGAVVALVVGFQSSSALASAYGIAVTLTMMIDTVLAFVVVRSLWKWGRAKAVLFLVVFLAVDIAFFSATTVKIFAGGWFPLLIGAAIFTLLRTWKRGRSLLNERIRSDTMPLDIFIQSMFQSPPPRVEGTAVFMTTWLDGVPRALLHNLIHNKVLHERVVLLRVDTADVPHVPEGERVEVEEIDYGFYRVRVHYGFKDDPDIPAALGLCAQRGLPFDMMETSFFLGRETLVSRVGSGMPQWREKLFILLFRNAGSAADYFCIPPNRVVELGTQVEL
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUVC_PORG3
Sequence: MSPKERIIMGVDPGTILMGYGMLHVAGNTPRLMAMGVIRLEKFDNHYIRLKRIFDRITGLIDEFLPDEMAIEAPFFGKNVQSMLKLGRAQGVAMAAALARDIPITEYAPMRIKQAITGNGNASKEQVAGMLQRYLRIPDEQMLPEMDATDGLAAAVCHFFQTSGPMARSGGSAVKNWKDFVNRNPDKVR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: YKH0_YEAST
Sequence: MYIPKHFESMELSRYKLSKKPPLGTLFSSKASRQGFFGWRTSSNKDDPDFGMCASHIPFVFVEFDNGEHKLIAHLARKNKHVEMLERVQKCLVVFQSVDSYISPAWFPMKKKTHKFVPTWDFAAVHVYGTPRIIRDDKDWLINMLSTLTDQEEEKRPEGENVRSKVERF
What are the official names of this protein?
Uncharacterized protein YKL070W.
Protein: TSAD_CAMC5
Sequence: MILGIESSCDDSSVALLDIKNLKLLYHKKISQESEHSPFGGVVPELAARLHTRALPALLEEIKPKFKDIKAIAVTNEPGLSVSLIGGVSMAKALSVALNVPLIAVNHLVGHIYSLFLDCEARFPLGVLLVSGGHTMVLDIDAAGKISLLAGTSDDSFGESFDKVAKMMQLGYPGGAAVQNLAWQCKDKRRFKFTIPFLHDKRLEYSFSGLKNQVRLEIEKIKGQNLAGATDRELSNDDMADICYAFENAACEHIMDKLTKIFKERSFKRFGIVGGASANLNLRSRIERLCLENGCELLLAPLEFCSDNAAMIARAGREKYLKGGFVKHNELNINPRVKF
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF2_METTH
Sequence: MSRRAKMISKIKELMYQPEYIRNIGIVAHIDHGKTTLSDNLLAGAGMISAELAGDQRFLDFDEQEQARGITIDAANVSMVHSYEGNEYLINLIDTPGHVDFGGDVTRAMRAVDGAVVVVCAVEGIMPQTETVLRQALKENVRPVLFINKVDRLINELKLDASELQERFVKIIANANKLIKNMAPEEFRDKWQVRVEDGSVAFGSAYHNWAINVPIMQETGINFNDIYKYCTEDNQKELAQKVPLHQVLLGMVVEHLPSPAESQAYRVPIIWSGDLESEEGQAMLKTDPEGPLAVMVTDVSIDKHAGEVATGRVYGGAIEKGSEVFLVGSHSKARVQQVGVYMGPERVNTDKVPAGNIVAITGAKNAVAGETICDTGRKIKAFEGLEHISEPVVTVAVEAKNTKDLPKLIEVLRQVGKEDPTVRVEINEETGEHLISGMGELHLEIIAYRINEKGVEIETSEPIVVYRETVAGTAGPVEGKSPNKHNRFYIEIEPVEASVMQAIQEGKIKEGRVKGKEMAKNFIEAGMDKEEARRVWDVYEKNLFINMTRGIQYLDEIKELLMDGFESAMDNGPVAKEKVMGVKIKLMDAKIHEDAVHRGPAQVLPAIRKGIFGAMMSAEPVLLEPIQKVFINVPQDYMGSATREIQNRRGQIVNMTQEGDMVTVESTVPVAEMFGFAGDIRSATEGRCLWSTENAGFERLPNELQHTITREVRTRKGLSPEPYRADHYLG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_RICBR
Sequence: MSTINTDANEAMPHISVNAQYIKDLSLENPDAPSSLAALEHRPQIDLSLDINITNLSEENFYEVELNIEAVARNEKYKLFQVELKYAGVFNLINIAPEQHQILLSVHCPAMIFPFARKIIASCTQDAGFQPLMIDPIDFGALYHKKMSEHQN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF1A_PICTO
Sequence: MASEKPHMNLVIIGHVDHGKSTLVGRLLFEHGEIPQHIIDEYKKEAEEKGKATFEFAWVMDRFKEERERGVTIDLTHRKFETDKYYFTIIDAPGHRDFVKNMITGTSQADAAVLVVSAREGEGVMAQTKEHAFLARTLGVPQLIAVVNKMDATQPPYSEKRFNEVKDEITKLLTPIGFKNVPIIPLSGYKGDNIMKPSPNLSWWKGPTLMEALNALQVPAKPVDKPLRLPVEDVYSITGIGTVPVGRIETGVMKVGDKVIFMPANKAGDVKSIEMHHEPMQQAGPGDNIGFNVRGIAKNELKRGDVCGPANNPPTVVKGFTAQIVVLNHPSVIAAGYKPVFHVHTAQVACRIDEIVKTINPKDGTTLKEKPDFIKTGDIAIVKVVPDRALVIEKVSEFPQLGRFAIRDMGMTVAAGQCIDLEKA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha, Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GOG6D_HUMAN
Sequence: MWPQPYLPPHPMMLEESRQNKLAAAKKKLKEYQQRKSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQHIQELERALCAVSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQPSGVTDGMRESFTVYESQGAVPNTRHQEMEDVIRLAQKEEEMKVKLLELQELVLPLVGNHEGHGKFLIAAQNPADEPTPGAPAPQELGAAGEQDVFYEVSLDNNVEPAPGVAREGSPHNNPTVQQIVQLSPVMQDT
What are the official names of this protein?
Golgin subfamily A member 6D.
What is the protein family that this protein belongs to?
Belongs to the GOLGA6 family.
Protein: O16C_CONPI
Sequence: DQCTYCGIYCCPPKFCTSSGCRSP
What are the official names of this protein?
Conotoxin pr6c.
What are the subcellular locations of this protein?
Secreted.
Protein: ARC_FRAAA
Sequence: MSGPRSGSGSGGSTGRPGDAESRRSAYEKEAHELTTQVAFLEEEVAMLRRRLSESPRQVRVLEERLAEVQAELSSATGQNDRLVATLREARDQIVTLKEEVDRLAQPPSGYGIFVSRYDDGTVDVFTQGRKLRVTVSPSVDVGSLSPGQEVMLNEALNVVEARSFERQGEIVLLKEVLESGDRALVIGHTDEERVVMLAQPLLDGPIRAGDSLLIEPRSGYAFERVPKSEVEELVLEEVPDIGYEQIGGLKSQIESIRDSVELPFLYKDLYREHQLKPPKGVLLYGPPGCGKTLIAKAVANSLAKKVEAITGQGNGRAFFLNIKGPELLNKFVGETERQIRLVFQRAREKASEGMPVIVFFDEMDSIFRTRGSGVSSDVENTIVPQLLSEIDGVEQLENVIVIGASNREDMIDPAILRPGRLDVKIKVERPDAEAARDIFAKYVVPSLPLYPEDLAEFDGNREATVAAMIQRVVERMYAESEENRFLEVTYANGDKEVLYFKDFNSGAMIENIVARAKKMAVKAHIEGGLKGLRMQYLLAACLDEFKENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGTKGTEAGRSIDTIANTGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Proteasomal ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: BAS3_MAGO7
Sequence: MQFSTVSFAIFAILPAMVAAMPAETSPVPKPALPVFEELCPDAERQKCAESTDNLKRCLQINGASICVIDCGSQTTCRTQCKQQLKNEKANGFCTVGDNPCICNLNGAANSAH
What is the function of this protein?
Secreted effector involved in biotrophic colonization of plant cells.
What are the official names of this protein?
Biotrophy-associated secreted protein 3.
What are the subcellular locations of this protein?
Secreted. Note=Localizes to the appressorial penetration site and outlines the primary hyphae.
Protein: HIS82_NOSS1
Sequence: MLPFIRSDLAQFNAYKPHPSSDTASAVPPQLDRLDTNESPYDLPPELKQKLAWTFQQVIESNRYPDGGHETLKSAIAEYVNESANISSLRFTAANISVGNGSDELIRSLLIATCLSGEGSILVANPTFSMYGILAQTLGIPVVSVSRNPDNFAIDLTAAQSAIEQTLNPPIRVVFVVHPNSPTANPLTANELRWLKSLSERILVVVDEAYFEFSQNTLVSELAQRPNWIILRTFSKAFRLAAMRVGYCVAHPEAIAILEKVRLPYNLPSFSIASALVALQNRAILLESIPQTLDERTKLINAFSQHPALAVAESAANFIFLRLKADSDNSSDTTLLNLHQQLKNSGTLVRQISGGLRITIGTPEENIRTLNHIQTALIKPELVG
What are the official names of this protein?
Histidinol-phosphate aminotransferase 2, Imidazole acetol-phosphate transaminase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: EFG_ECO24
Sequence: MARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMAKQYEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVNQIKTRLGANPVPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELANEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVEANVGKPQVAYRETIRQKVTDVEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDEAPSNVAQAVIEARGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPA_FRATF
Sequence: MSFIPHKLEQIKKMLDTIGASSVDQLFDEIPRHLRADTLNIKDGINEIQLANLMRKRANKNHHNINYIGAGAYSHHIPAAIWDIVARGEFYTAYTPYQAEASQGGLQVIYEFQTMMAGLTGMDASNASMYDGATALAESVLMAIRSNKKAKSQKVLIAEALHPTYLRVLETITKHQGIEFDIVNLDSKNGKTDVTKLEDFANTNYAAVVIQSPNFLGQLADVDGITNWAHKHGALVIAVTNPMSLAILKSPAEWGDNGADIVCGEGQPIGVPLASGGPYFGFMTCKMAHVRQMPGRIVGKTVDLDGNEGFCLTLQAREQHIRRAKATSNICTNQGLMVTAATIYMSLLGAEGLERVASISHENTQTLATELAKINGVSIRFNSAFFNEVVIDLPVNAETFVTEMEKEAIDAGYFLGEYHSDLANSIMVCATEIHTSEDIKEYIEATKKVLARIGG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: DTD_BACAH
Sequence: MRVVLQRSKEASVTVDGEIVGQIPFGLTLLVGITHEDTEKDATYIAEKIANLRIFEDESGKMNHSVLDVEGQVLSISQFTLYGDCRKGRRPNFMDAAKPDYAEHLYDFFNEEVRKQGLHVETGEFGAMMDVSLINDGPVTLIVESK
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLPL8_RAT
Sequence: MSINLTLDIYIYFLNNARSFCGKQRSKQLNFLCSKQYWRMNHVNVHREFHTSKKSCKWNRSEAHCSKHWHSSSNHGVHIGIVKLSTSAPKGLTKVSIHMSRIKSTLNSVSKAIFGSQNEMVSRLAQFKPSSRIFRKVSDRGWLKHKNVKQAIESLKNYSDKSAEKNSFAEQKSYFADKEEGSDKHSLYHYAYRITTRFGESFYFLANHINSYFKNKEKMSQIKEDRQLQDKPCLEESKSISPSPDILTDRPDSGPPLNVEDKLSSSTQLPEALPVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKSDPKSQPEEEEEPSKTDEPICKDKKAEEKKRVLLQREKIIARVSIDNRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKEKIIPYLLRLRQIKDETLQAAVREILALIGYVDPVKGRGIRILAIDGGGTRGVVALQTLRKLVELTQKPIHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFTQNVIVGTVKMSWSHAFYDSHTWEKILKDKVGSALMIETARDPLCPKVAAVSTIVNRGQTPKAFVFRNYGHFPGTNSHYLGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQDGGLLLNNPSALALHECKCIWPDTPLECIVSLGTGRYESDVRNTTTYTSLKTKLSNVISSATDTEEVHIMLDGLLPADTYFRFNPVICENIPLDESRNEKLDQLQLEGMKYLERNDEKMKKLAKILSREKTTLQKISDWIKLKSDMYEGLPFFSKL
What is the function of this protein?
Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors.  Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former.  Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine.  However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling.  On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates.  Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers.  Can also hydrolyze lysophosphatidylcholine.  In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling.  It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition.
What are the official names of this protein?
Calcium-independent phospholipase A2-gamma, Intracellular membrane-associated calcium-independent phospholipase A2 gamma, iPLA2-gamma, Patatin-like phospholipase domain-containing protein 8.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
Protein: RS11_VIBC3
Sequence: MAKQPTRARKRVRKQVADGVAHIHASFNNTIVTITDRQGNALAWATAGGSGFRGSRKSTPFAAQVAAERCAEMAKEYGLKNLEVMVKGPGPGRESTVRALNAAGFRITNIVDATPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: PRMA_HAEIN
Sequence: MAWIQIRLNSTNEKAEQMSDFLEEIGSVSVTFMDSQDTPIFEPLPGETRLWGNTDVIALFDAETDMAEIVRLLKEAKHLDSNTAYKIGTNRRLKNWEREWMDNFHPMQFGKRLWICPSWRDVPDENAVNVMLDPGLAFGTGTHPTTALCLEWLDGLDLKDKSVIDFGCGSGILAIAALKLGAKSAVGIDIDPQAILASRNNAEQNGVTDRLQLFLSDEKPSDLKADVVVANILAGPLKELYPIISQLVKPNGDLGLSGILETQAQSVCDTYTQTFALEPVAAREEWCRITGKLKTL
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_ECOLC
Sequence: MPKIKTVRGAAKRFKKTGKGGFKHKHANLRHILTKKATKRKRHLRPKAMVSKGDLGLVIACLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RL22_THETH
Sequence: MEAKAIARYVRISPRKVRLVVDLIRGKSLEEARNILRYTNKRGAYFVAKVLESAAANAVNNHDMLEDRLYVKAAYVDEGPALKRVLPRARGRADIIKKRTSHITVILGEKHGK
What is the function of this protein?
The globular domain of the protein is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that penetrates into the center of the 70S ribosome.  This extension seems to form part of the wall of the exit tunnel (By similarity).  Deleting residues 82 to 84 (the equivalent deletion in E. coli renders cells resistant to erythromycin) would probably cause the tip of the hairpin to penetrate into the tunnel.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CH60_SHEWM
Sequence: MAAKEVLFGNDARVKMLAGVNVLANAVKVTLGPKGRNVVLDKSFGAPLITKDGVSVAKEIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVTEGLKAVAAGMNPMDLKRGIDKAVVAAVAELKNLSQECADTNAIAQVGTISANSDETIGEIIATAMEKVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELESPFILLVDKKVSNIRELLPILEGLAKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAILTGGTVIAEEIGLELEKATLEDLGTAKRVIITKDDTTIIDGTGEQDQIQARVAQIKVQAEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALVRVASKIADVEVINEDQKHGVVIALRAMEAPLRQIATNAGEESSVVANNVKNGSGNYGYNAGNDTYGDMLEMGILDPTKVTRSALQFAASIAGLMITTEAMVGEVPQEAAGAPDMGGMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STAR_BOVIN
Sequence: MLLATFKLCAGSSYRHVRSMKGLQQQAVLAIGQELNRRALGGPAPAAWINQVRRRGSLLGSQLEDPLYSDQELAYIQQGEEAMQRALGILKDQEGWKKESRQANGDEVLSKVIPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTVITHELAAEVAGNLVGPRDFVSVRCTKRRGSMCVLAGMATLYEEMPQQKGVIRAEHGPTCMVLRPLAGSPSRTKLTWLLSIDLKGWLPKTIINQVLSQTQVDFANHLRKRLESCPALEARC
What is the function of this protein?
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone.  Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).
What are the official names of this protein?
Steroidogenic acute regulatory protein, mitochondrial, StAR, START domain-containing protein 1, StARD1.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UNG_CAMC1
Sequence: MQINLNDVKIEPSWKEVLKDEFLSENFARIKENFLKAKSAGVVYPPSGLIFNAFNLTPFHDVKVVILGQDPYHGANQAMGLSFSVPSGVRVPPSLVNIYKEIYADLGIKEPNSGDLTKWAKQGVLLLNSTLSVSAGAANSHASFGWQGFTDAVIRKISENLQNVVFMLWGNPAKAKAPLIDASKHLILEAAHPSPLARGAFFGCRHFSKANIYLAKHGKTPIEWDLNTKI
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.