PharMolix/UniProtQA huggingface dataset:
Protein: RL11_NOSP7
Sequence: MAKKVVAVIKLALNAGKANPAPPVGPALGQHGVNIMMFCKEYNAKTADQAGMVIPVEISVFEDRSFTFVLKTPPASVLIRKAAKVEKGSNEPNKKKVGSITKAQLQEIAQTKLPDLNANDIDAAMKIVAGTAKNMGITVKD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RLMN_SYNFM
Sequence: MEPVCVKDFTLPELEEWVQGIGERSFRARQLFRHVYGRGVRSWSECSDLSRMFRVQLEHGVELDALSVLKKEQADDGTSKYLFGLRDGHSIEAVLIPDLPRSTLCVSSQVGCALGCKFCLTGSLGFKRNLSAAEIVDQVCQVQRDLGSRSRITNIVFMGMGEPLANLDSVLRAIRVIAEPNGMAFSHRRITLSTAGLVPQLRRLGRESPVNLAVSLHAAENELRAELMPVNRTYPLEVLMAACREYPLPPRKRITFEYILLDGINDDPKQAKQLVKLLHGIRAKVNLMPFNPHPGSVFRKPSEQRVLAFQEALQNARITTHVRRSRGGEIGAACGQLVAEYG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTP1_TERAN
Sequence: ITAGSSLAGTTLSGLAASGYRVTCAIQVENWTRYPLLYPTVRVNYNGAVTVNPSPILPGKKEGFSVRKPSGTATGVSGTVSWELSGAHRRFVLMWSAPFNFDHYSNWMGVGLTQPGVTRVPPGKAWFDLMYYGPTDCKGELRYERGEFYYTIDPVIYRDENFEIVGTMTNVHNALIKVVIRPTRKNWKDL
What is the function of this protein?
Pore-forming protein that forms pores of around 1 nm and causes cardiac stimulation and cytolysis.
What are the official names of this protein?
Tereporin-Ca1, Actinoporin-like protein.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Conoidea subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: C71C4_MAIZE
Sequence: MAAQLHHALYELLHEAAAAQRALLLAIPFSLLLLPLLLRYLAASASASATKNDGAAPASDPDKLLSLLPSPPMKLPIIGHLHLMGDIPYVSLAALATRYGPDLMLLRLGAVPTVVVSSPRVAEAVLRTYDHVFSSRPRSLVSDIIMYGATDSCFAPYGDHFRKARKLVTVHLLNASKVRSQRPAREEEVRGALDRVRRAAAAREPVDMSELLHSFVNNLVCRAVSGKFSMEEGRNRLFRELTDINAGLLGGFHIQDYFPRLGRIELVRKVACAKTRRVRKRWDDLLDKLIDDHAARMATHQDEDDDKDFIYVLLSLQKEYGLTRDHIKAILIDMFEAGTDTSYMTLEFAMTELIRKPHLMKKLQEEVRRNVPAGQEMVTEDNLPGMTDLKAVIKETLRLHPPVPLLLPHYSLDACEVAGYTIPANTRVVVNAWALGRHSGYWERENEFVPERFLSGDVAGGVDLKPNEFQFLAFGSGRRMCPGVHSASATIEAMLSNLMYRFDWQLPAGMKAEDVDMTEVFGITVSRKEKLLLVPQAA
What is the function of this protein?
Catalyzes the conversion of indole to indolin-2-one.
What are the official names of this protein?
indole-2-monooxygenase, Cytochrome P450 71C4, Protein benzoxazineless 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DCC1_MOUSE
Sequence: MSPPSASRRTREEVDATLQVAKLNATELLPTVHCLSFSSGTGGAATGDFCLLELEPALCQQLEAGDSFVIRGDKDEQAVLCSKDKTYDLKIADTSNMLLFIPGCKTPDQLKEEETPSAIVHTEIFGFSNNYWELRRCRPKLKKLKRLLMENTYEGPDSQKEEDASRSKYTTEDLLNHIQASEEEIMAQLQVLNACEIGGYWRILEFDYEIKLLNHVTQLVDSESWSLDRVPLTVCLQELGPLEPEEMIEHCLKCYGKRYVDKDDVYFELDADKICRVTAEMLLQNAVKFNLAEFQEVWQQSVPEGMTTRLDQLKGLALVDRNSRPEIIFLLKVDDLPEGTQDRFNSLFSLREKWTEEDITPYIQDLCGEKQTIGALLTKYSRSSMQNGIKVYNSRRLIS
What is the function of this protein?
Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks.  May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity).
What are the official names of this protein?
Sister chromatid cohesion protein DCC1, Defective in sister chromatid cohesion protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the DCC1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: E1BS_ADES7
Sequence: MDLRTALQTFESTRRLLELCSNRTSFLWRWLFGTPLSRLVRQVKLEYEKDFERILDQCPGVFESLELGYHKVFEEKIVKELDFSSPGRAVAAVAFASYLLDRWNTRTHLSPGYQMDYISLNLWKFWLRRRVYNYSRGLPQLGPAAPLARQGSQQEEQQQRQEEEQVQEEMRSGLDPPTEN
What are the official names of this protein?
E1B protein, small T-antigen, E1B 19 kDa protein, E1B-19K.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1B 19 kDa protein family.
Protein: SYH_PHYAS
Sequence: MFYKIKGTHDLLPTQTTSWQKVENSFHSFFKKHQFQEIRTPIMEYAEVFHRAAQHSEMVSKETYAFPDKKNRLITLRPEGTAGIVRSYIENKLDQTNKLQKFYYYGPYFRYERPQFGRYRQFHQLGVEVLGKTTPFLDIEVITLIYQFLKSLGLDDITIQINSLGSKEDHLDYVDIFKQYLKIYSNYLCGLCHERLNKNPLRIWDCKTCHLQDFLKQAPKIFDSLSPKSKKRFQTVLNGLEAMKVNFKTCHDLVRGLDYYTHTVFEITFNKMVLGGGGCYDHLVAALGGNQLSGIGFALGMERLMLTLQENNNFFVSPQPSLKLFLFILDPVFFHHGLTLVHILRNEGFCVEFNYSFTTFTKGLKEALKCLPNYLLILGHQEFAKKQITIKNIKTHTQTTIDQKDLIFYFQQQRV
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBC12_XENTR
Sequence: MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCEIEFSDHDDLLNFKLVICPDEGFYKGGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK
What is the function of this protein?
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins.  The specific interaction with the E3 ubiquitin ligase rbx1, but not rbx2, suggests that the rbx1-ube2m complex neddylates specific target proteins, such as cul1, cul2, cul3 and cul4.  Involved in cell proliferation.
What are the official names of this protein?
NEDD8-conjugating enzyme Ubc12, NEDD8 carrier protein, Ubiquitin-conjugating enzyme E2 M.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Protein: RL6_CLOBK
Sequence: MSRVGKLPVAIPNGVTVTVTPDNVVTVKGPKGELVKAMSNKINIAVEDNSVVVTRDNDHKDVRALHGLTRALINNMVTGVNEGYVKTLELVGVGYRAQLQGKKLVLSLGFSHPVEMEAVSGVEFEVEGGTKVKVKGIDKELVGAVAADIRKWRKPEPYKGKGIKYENEVIRRKEGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: NIFH1_CLOPA
Sequence: MRQVAIYGKGGIGKSTTTQNLTSGLHAMGKTIMVVGCDPKADSTRLLLGGLAQKSVLDTLREEGEDVELDSILKEGYGGIRCVESGGPEPGVGCAGRGIITSINMLEQLGAYTDDLDYVFYDVLGDVVCGGFAMPIREGKAQEIYIVASGEMMALYAANNISKGIQKYAKSGGVRLGGIICNSRKVANEYELLDAFAKELGSQLIHFVPRSPMVTKAEINKQTVIEYDPTCEQAEEYRELARKVDANELFVIPKPMTQERLEEILMQYGLMDL
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein 1, Nitrogenase Fe protein 1, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: FEOB_ECO57
Sequence: MKKLTIGLIGNPNSGKTTLFNQLTGARQRVGNWAGVTVERKEGQFSTTDHQVTLVDLPGTYSLTTISSQTSLDEQIACHYILSGDADLLINVVDASNLERNLYLTLQLLELGIPCIVALNMLDIAEKQNIRIEIDALSARLGCPVIPLVSTRGRGIEALKLAIDRYKANENVELVHYAQPLLNEADSLAKVMPSDIPLKQRRWLGLQMLEGDIYSRAYAGEASQHLDAALARLRNEMDDPALHIADARYQCIAAICDVVSNTLTAEPSRFTTAVDKIVLNRFLGLPIFLFVMYLMFLLAINIGGALQPLFDVGSVALFVHGIQWIGYTLHFPDWLTIFLAQGLGGGINTVLPLVPQIGMMYLFLSFLEDSGYMARAAFVMDRLMQALGLPGKSFVPLIVGFGCNVPSVMGARTLDAPRERLMTIMMAPFMSCGARLAIFAVFAAAFFGQNGALAVFSLYMLGIVMAVLTGLMLKYTIMRGEATPFVMELPVYHVPHVKSLIIQTWQRLKGFVLRAGKVIIIVSIFLSAFNSFSLSGKIVDNINDSALASVSRVITPVFKPIGVHEDNWQATVGLFTGAMAKEVVVGTLNTLYTAENIQDEEFNPAEFNLGEELFSAVDETWQSLKDTFSLSVLMNPIEASKGDGEMGTGAMGVMDQKFGSAAAAYSYLIFVLLYVPCISVMGAIARESSRGWMGFSILWGLNIAYSLATLFYQVASYSQHPTYSLVCILAVILFNIVVIGLLRRARSRVDIELLATRKSVSSCCAASTTGDCH
What is the function of this protein?
Probable transporter of a GTP-driven Fe(2+) uptake system.
What are the official names of this protein?
Fe(2+) transporter FeoB, Ferrous iron transport protein B.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEXM_HUMAN
Sequence: MRESQDAAGAHGWNRVGSTATKWFTGAPFGVQSHRFDISAVYPNWKKFSTFTEAPYSTRYSTQVSHIGPGTYSSKETCFSKKKLMKEVDTGWAKAQEATRLTQLPHFQYQAIMKEKRLKEQKLGPGSYNLKDFLEQLREKPCSTRGLLSSGEVRFRGLTGNYYPGPGNYGEKGNPYTKLEENAWNRSHSEGLMCRMSNKPHPRPHQGSGLGPGTYFFKSDLETYVARSVGTRGPYDTFSGDRSKPLPYGHYSMQKKKPRELMNFKSFVEELNSHHNKKHGVFSKLPRNPKTPTERIYWANLSQCPRTLATSGPSFWLPQEKKCKPVNQPPFLLTSKGSGAKACQMIMGSWNPVGVGRYLNTWLMETKDRRQRYRSLFLSGSKRYLSDLARDMLMQERITPFTKGKCPPTVDYNSDPTP
What are the official names of this protein?
Lymphocyte expansion molecule.
Protein: FAR9_PRAMA
Sequence: GRGGPSNYVRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-9, FMRFa-9.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y030_BRUA2
Sequence: MRDMMGMMKQAKELQAKMKAMQDEIATMEASASSGGGLVTVTLSGKGTLSALKIDPSLMKEDEVEILEDLIIAAHNDAKAKLEAAMAEKTQSLTAGLPIPPGFKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein BAB1_0030.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RS20_CHLPM
Sequence: MPLHKSAEKRLRQSDRKNARNRARKKELKVLVKNMQKLVDAGAPKPEVEVAYRSAVQKLDRLGVKNYIHANKASRKKSQLARILNEYGKAE
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: ACDH_SPIAU
Sequence: MGRFPLAAKPLQVAILGTGNIGTDLLLKIQRSQLLKCVAFVGRSSQSSGMVKARSLGVPCSDLSIEYFRQNGEKIDLVFDATSAKDHLVHAPILRELGIRVIDLTPAKVGKMCIPAVHRSSLLNEWNLNMVTCGGQASSPLAWAIGQTQGSIEYLEVVSSIASKSAGPATRLNLDEYIHTTEKALAELSGAKNTKAILVLNPAEPCIDMQTTVFAKVDSPDLLKLQKLLSEVIPRTQAYVPGYQVALGPIVDNGRISIMVRVRGVGDYLPEYAGNLDIINCAAIAMAEEYAKAAHEQ
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: BDNF_ASPME
Sequence: SCMKAAPMKEVSIRGQGSLAYPGLQTQGNLETLSGPNDATRGLTSLADTFEHVIEELLDEQQVIQSSKENKDADLYSSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCSSKGYAKEGCRGIDKRYWNSQCRTTQSYVRALTMDNKKRVGWRFIRIDTSC
What is the function of this protein?
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROA_SHIB3
Sequence: MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARISQAA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_METFK
Sequence: MTAMRNAEVSRNTLETKIAVAINLDGTGISRLNSGVGFFDHMLDQIARHGMMDISVECQGDLHIDAHHTVEDVGIALGQAFSKALGDKKGIRRYAHAYVPLDEALSRVVLDISGRPGLEFNVEFTRARIGEFDVDLVSEFFQGFVNHAAITLHIDNLRGKNAHHQAETIFKAFGRALRAAVELDPRMVGIMPSTKGSL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHS_MYCSK
Sequence: MAVLTDDQVDAALPELGGWERADGALRRSVKFPAFLDGIEAVRRVAERAEAKDHHPDIDIRWRTVTFVLVTHSEGGITEKDLQMAREIDEILDR
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: LEXA_SHIB3
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLQEEEEGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPNADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFKPIVVDLRQQSFTIEGLAVGVIRNGDWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RL6_AZOC5
Sequence: MSKIGKHPVAIPAGVTASVDGQTVKVKGPKGALEVVLVEEIQASLEGGELKIAMRGETPRHKSMWGMSRTLVANLVEGVTKGFEKKLEINGVGYKAAVAGKNLQLSLGYSHDVIYPIPEGIQIAAPKPTELVVTGINKQQVGQVAAEIREFRGPEPYKGKGVKYAGEFIFRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: IBP6_RAT
Sequence: MTWDGLPTQPLLMLLMLLFAAGSESALAGCPGCGPGVQEEDAGSPADGCAETGGCFRREGQPCGVYIPKCAPGLQCQPRENEETPLRALLIGQGRCQRARGPSEETTKESKPHGGASRPRDRDRQKNPRTSAAPIRPSPVQDGEMGPCRRHLDSVLQQLQTEVFRGGANGLYVPNCDLRGFYRKQQCRSSQGNRRGPCWCVDPMGQPLPVSPDGQGSSQCSARSSG
What is the function of this protein?
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.  They alter the interaction of IGFs with their cell surface receptors.  Activates the MAPK signaling pathway and induces cell migration.
What are the official names of this protein?
Insulin-like growth factor-binding protein 6, IBP-6, IGF-binding protein 6, IGFBP-6.
What are the subcellular locations of this protein?
Secreted.
Protein: APT_SALA4
Sequence: MTATAQQLEFLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIELLVERYKNAGITKVVGTEARGFLFGAPVALGLGVGFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDNVLVVDDLLATGGTIEATVKLIRRLGGKVTDAAFIINLFDLGGEQRLEKQGITCYSLVPFPGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SBNA_CUPMC
Sequence: MVCNSIIESIGNTPLVQLRRLFGRADAEVFAKLELLNPAGSVKDRPARYIVEKGLTEGAIGPHSHVIESSSGNLAIALAMICGLKGLRFTAVVDPKISPTNLKILRCYGAGIEQVTAKDSQGGYLETRIERVRQMLREQRDAIWINQYANPLNWESHYYGEAAEILAQLAQPADVLVLGVSTSGTVHGIARRLRKAWPSMRVVGVDAVGSVLFGQPSQARELPGIGASRVPELLCRDEIDEVIHIDDYTAATACRRLLAREGIFAGGSSGAVVAAIEQVLHATPVSHRPLRILTLFPDRGERYLDTVYDDAWLARIAARRAVPNLAALPTVASLIPAGVSA
What is the function of this protein?
Catalyzes the synthesis of N-((2S)-2-amino-2-carboxyethyl)-L-glutamate (ACEGA) from O-phospho-L-serine and L-glutamate.
What are the official names of this protein?
N-(2-amino-2-carboxyethyl)-L-glutamate synthase, ACEGA synthase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family. SbnA subfamily.
Protein: SYE1_FERNB
Sequence: MSEVRVRFAPSPTGYLHVGGARTALFNYLYARKTGGKFILRIEDTDLERSEKVFEEQLISALKWLGLEWDEGPDIGGQYGPYRQSERVHLYHEYAQKLIEEGKAYEVYAYPEEIEQLREKLLSEGKAPHYTREMLEPYNTPERKKEYEEKGLKPAVYFSMLRKDYVINDVVKGEVVFKAGSVGDFALLRSNGMPTYNYACVIDDGLMKITHVLRGDDHLSNTVKQVALYEAFGWPTPVFGHVSMILGPDGSKLSKRHGATSVEEFKSRGYLPEALVNFLALLGWSHPEGKEILTKQELIESFSLERLVKNPAIFNPEKLKWMNSEHIRMKSMDELVKIAKPFLQKDVDDEYFAKILHAVKDRIEELSQLPELTDIFFEKPHQLPEKTPEAIETYTNLLSELKKIEKWDKDSIYAAFKTAMKSAKLKGKDFYMTLRLVLTGKTEGPELIDILEILGKDEVIERISLYLNK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MKAR_CANAL
Sequence: MPFTQFLDKYSDNLAIQYAIIFALLLGVFKLTVFSLKFASLIYDIFLAPATDFSKYGAASGKWAVVTGASDGIGKEYAFQLAKKGFSIVLVSRTQSKLELIATEIESKYKVNTKIVAFDASTDDEENYLKLEKAVFDLPVTILINNVGQSHSIPVPFLKTEKKELKDIITINTTATLRITQIVAPIIVSTVENPHPKQLRGLILTMGSFGGLLPTPYLATYSGSKSFLQAWSAALAGELQADHVDVELVISYLVASAMSKIKRTSLSIPNPKQFVTSTLNGVGRRNGAQERFATSTPYWTHALMHFAIDNTVGVYSKIANKLNLQMHQSIRRRALKKAARLAAAAEKKD
What is the function of this protein?
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate.  Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation.  VLCFAs serve as precursors for ceramide and sphingolipids.
What are the official names of this protein?
Very-long-chain 3-oxoacyl-CoA reductase, 3-ketoacyl-CoA reductase, 3-ketoreductase, KAR, Microsomal beta-keto-reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: FOLD_NITMS
Sequence: MTGTKIDGKVISQSVKDRVKKAVEELKNQGINPCLATVLVGDNPASATYVRNKHRACEEVGITTKDHKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQLDEFTTTSRISPLKDVDGLTPHNAGLLAMKKAALVACTPSGVMEMFDYHGIELEGKNIVLINRSNLVGKPLYHLLLDKNATVITCHSRTKNLVELCQSADIIITAVGDRNKFTLTSDMIKEGAIVIDVAISRFQEKLVGDADYEDIIQKASFATPVPGGVGPMTVAMLLKNTITAASLSSQIGK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CALM_STRPU
Sequence: LTMMARKMKETDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVAMMTSK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: NRDR_BURP1
Sequence: MRCPFCRHDDTQVVDSRVSEDGAAIRRRRRCSACDKRFTTYERVELALPAVVKKDGSRTEFDRRKIVASMQLALRKRPVAADAIDAAVARIEYQLLASGEREVRSEKLGELVMNELRQLDTIAYVRFASVYRRFEDVSEFEDVIEEFRRAAPAKTPRKR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RS5_METLZ
Sequence: MAYEQEVWVPVTGLGKKVMAGEFASFDEILASGQPIKEAGIVDAMLPDLVDEVLCIDMMQRMTDSGRRIKFRAVVVIGNKNGYVGFGQGRDVQVGTAIKKAITNAKLNIVKVRRGCGSWECGCGMKHSVPMEVTGKAGSVAVTLKPAPKGIGLVTGDVGKKVLTLAGIQDVWVNTSGNTRTTLNFAKATYNALRETNLIRIGGRK
What is the function of this protein?
With S4 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: ATPO_DICDI
Sequence: MLARFSRTAIKSGRYFSTSAKNTAPVSEAEEIEILKAVEAPQFKDAVKKTRQQYQDMISKLTNDESGKSITQSTGLRPTINISTPSGKIAHALFDAASSMRSVGIVAKELTQVKTIIDKTPGLKTALEGDIDNSEKTVMLELLQGSVTLSPVSGFFLYYMTYENNFKLINPALTDFKRLVGSLDTEMSIKLTVAHQYSEAEKKDLETNVKSFFPPETQFKFSYNVDPEIQKGYIIESPFINHDASYSTAVKKVKAQEQSVLAEFLNDIKNGIKNQTAVWETKEFRDKYLTLDESKN
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
What are the official names of this protein?
ATP synthase subunit O, mitochondrial, ATP synthase peripheral stalk subunit OSCP, Oligomycin sensitivity conferral protein, OSCP.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: MSOX_BACSN
Sequence: MSTHFDVIVVGAGSMGMAAGYYLAKQGVKTLLVDSFDPPHTNGSHHGDTRIIRHAYGEGREYVPFALRAQELWYELEKETHHKIFTQTGVLVYGPKGGSAFVSETMEAANIHSLEHELFEGKQLTDRWAGVEVPDNYEAIFEPNSGVLFSENCIQAYRELAEAHGATVLTYTPVEDFEVTEDLVTIKTAKGSYTANKLVVSMGAWNSKLLSKLDVEIPLQPYRQVVGFFECDEAKYSNNAHYPAFMVEVENGIYYGFPSFGGSGLKIGYHSYGQQIDPDTINREFGAYPEDEANLRKFLEQYMPGANGELKKGAVCMYTKTPDEHFVIDLHPKYSNVAIAAGFSGHGFKFSSVVGETLAQLATTGKTEHDISIFSLNRDALKKEAVK
What is the function of this protein?
Catalyzes the oxidative demethylation of sarcosine.
What are the official names of this protein?
Monomeric sarcosine oxidase, MSOX.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family. MSOX subfamily.
What are the subcellular locations of this protein?
Cytoplasm.