PharMolix/UniProtQA huggingface dataset:
Protein: MUTS_BORBU
Sequence: MEKNVTPMIRQYLDIKKKYKDAVLFFRVGSFYEMFFDDAIEVSKLLNLTLTKRENVPMCGVPYHTSKEYIRKLILFDKKVAICEQASNSTSGGPLEREVVEVITPGVIIDEDFLNDDINNYLVAISDYKDYYSFSYIDLSTSSLGIMFYENGFFEKLKRDLEKYSPKEIIVSENFYYEYSEKLNLSRFLINRVPTWHLDKDIAIKTIKEHFNILGLSSLGFDEEKPYYISIFLIINHIKNNLKNLLSNIDKIDINNDSSYMFLDDVTQVNLELVKNNNDFSSQYSLYSVLNDCKTAMGKRLLREFILNPILNISEINTRLDHVEFFCKNISLTVTLRETFINIWDIERIISRIQMKRYIKKDFLFIEKALSVFFTVKKLFDKHNFDYWNFDKFEEDSISKVYFLINSAISSAPDELIKRGYDLKLDNLKDLKINANKYIDQYLESERLLSKINNLKIRKTNNRGLFFEVTKSNYAQVPPHFMESQALNSSKRYKTEKLISLEVDINNAEDNVVAFEQEIFDEIASNVVMHNKVLKKVAEFFAYIDLVVNFGYLAKKNEYKRPVLTSGKEILLEKSRHPVVEHYTKNTEIFTENFVRINKEKYFCLITGPNMAGKSTYLRQVALITLMAHIGSFVPASKALIGITDKIFCRIGASDNIAKGESTFLVEMNETANILRNATEKSLIIMDEVGRGTSTNDGLAIAYSIIEYILEYIKARSLFATHFHELSSINHQAFINLSMKIEKQGNDLVFLREVEEKPSLNSYGIYVARIAGLPLRVIDRANVILESLVGREGNSCLEFLPHVSSDGNDKEILKNDTDIHIKLNEYLELKNFISNIDINNITPFQSIELLNQIVLKVISQSS
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: FABI2_ORYSJ
Sequence: MGASVTTGLQMAAARPCIPACQRLLGSRAALPSFGRALSTQTGFASCRKTASAGPFVSLNHKRFAVRAMSAQGLPIDLRGKRAFIAGVADDNGYGWAIAKALAAAGAEILVGTWVPALNIFETSLRRGKFDESRKLPDGSLMEITKVYPLDAVFDSPEDVPDDVKANKRYAGSSNWTVKEVAETVKNDFGTIDILVHSLANGPEVKNSLLETSRKGYLAAVSASSYSFISLLQHFLPIMNPGGATISLTYIASERTIPGYGGGMSSAKAALESDTRVLAYEAGRKGKIRVNTISAGPLGSRAAKAIGFIEKMIEYSYVNAPLQKELLADEVGNTAAFLASPLASAITGSTIYVDNGLNTMGLALDSPTLST
What is the function of this protein?
Catalyzes the NAD-dependent reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).  Catalyzes the last reduction step in the de novo synthesis cycle of fatty acids.  Involved in the elongation cycle of fatty acids which are used in lipid metabolism.  Required for normal plant growth (By similarity).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH] 2, chloroplastic, ENR, NADH-dependent enoyl-ACP reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: 1433A_VICFA
Sequence: MATAPTPREEFVYMAKLAEQAERYEEMVEFMEKVTAAVESEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNDEHVSVIRDYRSKIETELSNICNGILKLLDSRLIPSAALGDSKVFYLKMKGDYHRYLAEFKSGAERKDAAESTLTAYKSAQDIANTELPPTHPIRLGLALNFSVFYYEILNSPDRACGLAKQAFDEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQDDGADEIKEAAPKGNDEPQ
What are the official names of this protein?
14-3-3-like protein A, VFA-1433A.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: CWC15_MOUSE
Sequence: MTTAARPTFEPARGGRGKGEGDLSQLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRNRDFRRELEERERAAARDKNRDRPTREHTTSSSVSKKPRLDQIPAANLDADDPLTDEEDEDFEEESDDDDTAALLAELEKIKKERAEEQARKEQEQKAEEERIRMENILSGNPLLNLTGPSQPQANFKVKRRWDDDVVFKNCAKGIDDQKKDKRFVNDTLRSEFHKKFMEKYIK
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome.  Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
What are the official names of this protein?
Spliceosome-associated protein CWC15 homolog, Embryonic development factor 1, mED1.
What is the protein family that this protein belongs to?
Belongs to the CWC15 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GPSB_BACP2
Sequence: MLADKVKLSAKEILEKEFKTGVRGYKQEEVDKFLDMVIKDYETFNQEIEKLQQENLHLSKQLEEAVEQGKRQPAQSNTTNFDILKRLSNLEKHVFGSKLYD
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: HXA4_CHICK
Sequence: MTMSSFLINSNYIEPKFPPCEEYTQHSGSAGSSASYHPHHPHPHAPPPPPPPPPPHLHAAHPGPALPEYFPRPRREPGYQAPAAPPGPPGPPPEALYPAQAPSYPQAPYSYSSAGSAAPGPEQPPPGASPPPPPPAKGHPGPAQPLLPGHALQRRCEAAPAAGAGTGPGCALLPDKSLPGLKGKEPVVYPWMKKIHVSTVNPNYSGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNQPSLGQQQAKAQTQGHPRPLDGAAPNAAAL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Binds to sites in the 5'-flanking sequence of its coding region with various affinities.  The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
What are the official names of this protein?
Homeobox protein Hox-A4, Homeobox protein Hox-1.4, Chox-1.4.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Deformed subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRB_CHRVO
Sequence: MYRKHIISIPDFSREELELVVDTAARLKQSPRGDLLQDKLVASCFFEPSTRTRLSFETAVQRLGGNIIGFADGGNTSAKKGETLADSIKIISSYTDAVVMRHPKEGAARLASEFSAVPVINGGDGSNQHPTQTLLDLFSIRETQGRLDGLTVAFAGDLKYGRTVHSLAQALSLFGARFYFVSPEVLAMPDYICEELDEKGISYTVADSLEAVIPEVDVLYMTRVQRERFDEAEFRKIQGQYALRADMLKHARPGMKVLHPLPRVDEIAVDVDATPHAYYFEQAKNGVYARQALLSLVLNETV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: DUT_HELAH
Sequence: MKIKIQKIHPNALIPKYQTEGSSGFDLHAVENAVIKPHSVGLVRIGICLSLEVGYELQVRTRSGLALNHQVMVLNSPGTVDNDYRGEIKVILANLSDKDFTIQVGDRIAQGVVQKTYKAEFIECEQLDETSRGSGGFGSTGVSKA
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: ASSY_MYCSS
Sequence: MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMDVVRQRALDCGAVEAVVIDARDEFAEDYCLPAIQSNALYMDRYPLVSALSRPLIVKHLVDAAREHKGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEENAIPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDVYDYTEDPTLNWSTPDEVIVGFDKGVPVSIDGRDVTVLQAIEELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFKRTTDQKWGELVYDGLWFSPLKTALESFVAKTQEHVSGEIRLVLHGGHIAVNGRRSQESLYDFNLATYDEGDTFDQSSAKGFVHVHGLSSSISARRDLGIK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C135A_MYCTO
Sequence: MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFSLRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEHARMRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFGVTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIASRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLWELAHAPEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPAGTVVNTSILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTEGAVILQEIFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP
What are the official names of this protein?
Putative cytochrome P450 135A1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: LPXD_LAWIP
Sequence: MPQYKLSEIAKLLNLTLQGDDIEVVGVNTLQDASPNEISFLANAKYIHQLVLSQAGAIILSKEYASRVPRALISTEPYRDFGRVLSLFSIPQGCFDGISHQAYIHPTAQVSKTATIYPFVFIGSHTVIEENTTLFPGVYIGEHCHIGKNCTIYPNTVLMANTSIGNDCIIHAGVVLGSDGFGFALTEEKQKIPQVGNVIIKDKVEIGANTTVDRGTLGTTTINENTKIDNLVQIGHGVTVGKNTVIVSQVGISGSTSIGDNCILAGQAGISGHLTIGNNVTIGPQSGIGKNIPDNQILGGSPAVDRQTFLKTSVLMPRFPELFKRIKKLEKILEKKKEHNI
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: TRPM2_HUMAN
Sequence: MEPSALRKAGSEQEEGFEGLPRRVTDLGMVSNLRRSNSSLFKSWRLQCPFGNNDKQESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDPKKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTAQALHWIVRTLRASGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDSYHVNARHLLYPNCPVTRFPVPNEKVPWETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSFHGPYTVQAGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLEVLVVKLPLSEHWALPGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWIETVAVSVHFQDQNDVELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFGAHY
What is the function of this protein?
Lacks cation channel activity and negatively regulates the channel activity of isoform 1.  Negatively regulates susceptibility to cell death in reposponse to oxidative stress.
What are the official names of this protein?
Transient receptor potential cation channel subfamily M member 2, Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC-2, LTrpC2, Transient receptor potential channel 7, TrpC7, Transient receptor potential melastatin 2.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection. Cytoplasmic vesicle. Lysosome. Note=Detected at the cell membrane and in intracellular vesicles in cortical neurons. Detected on neuronal cell bodies and neurites (By similarity). Detected on the cell membrane in polymorphonuclear neutrophils. Detected on cytoplasmic vesicles and lysosomes in immature bone marrow dendritic cells (By similarity). SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Multi-pass membrane protein.
Protein: BETA_PSEAE
Sequence: MSQEFDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRFDFRTQMPAALAFPLQGRRYNWAYETDPEPYMNNRRMECGRGKGLGGSSLINGMCYIRGNALDFDGWAKEPGLEDWSYLDCLPYFRKAETRDIGPNDYHGGDGPVSVTTPKAGNNPLFHAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPEGRRAATGRGYLDQARGRPNLTIVTHALSDRILFSGKRAIGVSYLVGNGDNPVTAHARREVLVCSGAIASPQLLQRSGVGPAALLRDLDIPVVHDLPGVGANLQDHLELYLQYACKQPVSIYPATKWWNQPAIGAQWLFLGKGLGASNQFEAGGFIRTREAFEWPNIQFHFLPVAINYNGSKGVQEHGFQAHMGSMRSPSRGRIHLKSRDPRQHPSILFNYMSHEQDWQEFRDGIRLTREIMNQPALDPYRGRELSPGVSVQSDAELDEFIRNHAETAFHPSCSCKMGSDDMAVVDGQGRVHGMEGLRVVDASIMPLIITGNLNATTIMMAEKIADRIRGRQPLPRSTAKYYVAGDAPVRGNPVRA
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: Y3644_MYCBP
Sequence: MPGNSRRRGAVRKSGTKKGAGVGSGGQRRRGLEGRGPTPPAHLRPHHPAAKRARAQPRRPVKRADETETVLGRNPVLECLRAGVPATALYVALGTEADERLTECVARAADSGIAIVELLRADLDRMTANHLHQGIALQVPPYNYAHPDDLLAAALDQPPALLVALDNLSDPRNLGAIVRSVAAFGGHGVLIPQRRSASVTAVAWRTSAGAAARIPVARATNLTRTLKGWADRGVRVIGLDAGGGTALDDVDGTDSLVVVVGSEGKGLSRLVRQNCDEVVSIPMAAQAESLNASVAAGVVLAAIARQRRRPREPREQTQNRMI
What are the official names of this protein?
Uncharacterized tRNA/rRNA methyltransferase BCG_3644c.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: LOLB_PSESM
Sequence: MFLRHVIVFSFIALLAGCAGLTSREAVQGKGDPAQWREHKQQLSSLDGWQINGKVGIRAPKDSGSGTLFWLQRQDYYDIRLSGPLGRGAARLTGRPGAVALEVANQGRYEAPTPETLLQDQLGWKLPVSHLVWWVRGLPAPDSKSNVTLDGDSRLASLEQDGWQVEYLSYVEQNGYWLPERVKLHGQDLDVTLVIKDWQPRKLGQ
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: LSPA_FRAT1
Sequence: MNLLRPKLKYFILAILIIAADLYTKYLANTYLEFAQSLKITSFFNLTLLYNHGAAFSLLSNDQTSWQMIMFSTISLIAAIVLIYLIIKQPITEKINLFSFALILGGALGNFYDRAFQGYVIDFLDFHIGNYHWPSFNIADSAITCGVVILIAASLFTKKKS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS2_NITEU
Sequence: MTASTILQRLARTIEARKNADPSISYTAKLLNSSQDKVLKKIAEEAAETIMACKDNDREQIIYETADLWFHCLIMLTRHDISPEDILRELERREGISGIEEKLSRSQPNKTE
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROX2_HUMAN
Sequence: MDPNSILLSPQPQICSHLAEACTEGERSSSPPELDRDSPFPWSQVPSSSPTDPEWFGDEHIQAKRARVETIVRGMCLSPNPLVPGNAQAGVSPRCPKKARERKRKQNLPTPQGLLMPAPAWDQGNRKGGPRVREQLHLLKQQLRHLQEHILQAAKPRDTAQGPGGCGTGKGPLSAKQGNGCGPRPWVVDGDHQQGTSKDLSGAEKHQESEKPSFLPSGAPASLEILRKELTRAVSQAVDSVLQKVLLDPPGHLTQLGRSFQGQVAEGRSEPSPPVGGACKDPLALAALPRRVQLQAGVPVGNLSLAKRLDSPRYPIPPRMTPKPCQDPPANFPLTAPSHIQENQILSQLLGHRYNNGHWSSSPPQDSSSQRHPSSEPALRPWRTTKPQPLVLSQQQCPLPFTSAHLESLPLLPSVKMEQRGLHAVMEALPFSLLHIQEGLNPGHLKKAKLMFFFTRYPSSNLLKVYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKSARQAISDGVTNPKMLVVLRNSELFQALNMHYNKGNDFEVPDCFLEIASLTLQEFFRAVSAGRDSDPSWKKPIYKIISKLDSDIPEIFKSSSYPQ
What is the function of this protein?
Transcription regulator.  Does not seem to be essential for embryonic development and postnatal survival (By similarity).
What are the official names of this protein?
Prospero homeobox protein 2, Homeobox prospero-like protein PROX2, PROX-2.
What is the protein family that this protein belongs to?
Belongs to the Prospero homeodomain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRI10_MOUSE
Sequence: MASAPSVTSLADEVNCPICQGTLREPVTIDCGHNFCRGCLTRYCEIPGPESEESLSCPLCKEPFRPGSFRPNWQLANVVENIERLQLASTRGLEVEDACPEHGEKIYFFCEEDEAQLCVVCRETGQHGAHTVRFLEDAAGPYREQIQKCLVCLRKEREEIQETQSRENKRIQVLLTQVATKRQQVISQFAHLSQFLQQQQTALLAQLEGLDGDILKQQEEFDSLATGEICRFSTLIEELEEKNKRTARGLLTDIRSTLIRCETRKCRKPEAISPELGQRIRDFPQQAIPLRQEMKTFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHRRARFSYKWQNSPDTPQRFDRVTCVLAQCGFTGGRHTWMVNVDLAHGGSCTVGVVREDVRRKGELRLRPEEGIWAVRLAWGFVSALGSFPTRLALEEQPRKVQVSLDYEVGWITFVNAVTQEHIYTFTASFTQKIFPLFGLWGRGSSFSLSCQEGAVSLL
What is the function of this protein?
E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells (PubMed:18560381).  May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (PubMed:32343488).  In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity.  Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (By similarity).
What are the official names of this protein?
Tripartite motif-containing protein 10, Hematopoietic RING finger 1, RING finger protein 9.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_SHEPA
Sequence: MTNLTLALDAMGGDFGPRITVPASLQALRLNPLLKIVLVGDKTQIDEYIASAEPAIKRRIEIKHTTEVVAMSDRPVHALRNRKQSSMRLAIELVRDGKAQACLSAGNTGALMAMSKVLLKTLPGIDRPALVSCLPAVNNTPVYLLDLGANISCDSETLFQFAVMGSVLCETVDKTVSPKVALLNVGIEEIKGNDQVQQAGQLLQQIPQINYTGFIEGDEIYSGNVDVIVCDGFVGNITLKTSEGIARLLIHQLKKSLSDGFFVKILAKIIAPRIRSLLNQMNPDHYNGASLIGLRGIVVKSHGCADEAAFLQAITLAVTEAQRRLPQMIEDRLESILLDINS
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: GEFR_DICDI
Sequence: MKEEEIANLGPQEYFNYLEGINKKIIIELKTVANIDTAKDTDNLQNILIESSLALEHNIRNLLYFVDKCPISYDQIVHYHSHFKEVVKIFFQVCQDLIKAAQALILNSCDYLTTSNFAKCRGEAIKTIKNTMATCSNFEKLYYNPDLQLEDEVDLVHQQQQKEQEQQQKEQEQYEQEQLILKQLKEQELKKQQEQQQQQQQQQQQQQQQQQQQQQKHQEEKEKNDQKEKEEKLKKQLLAEQQKQKQEELERQQQQLQQQQQLLQQQQQLLQQQQQQQRSDPIIIPPITLKTSQSDLLSGGLSPKVNSPGSPNLGKFTESAERVANFDRGTANIILNMNKIKEISLSGDSEQAPEIVTAARIISENIAIISKELRYKTLGTNLSEHFVSVVQVARLAIKNKSDQFYQDQLELAIEKFNDTMRKIIYSVKSISKSSMNLRQFGVDESSLGRSPVVSPEKSISPSFTSSTSERILSHEIKNHNNNNNNYNNSSTNNLQTSFSTPSLSSNHSQQPNQQPLQSPLLINQLQSTSSSSSSSSSNLSNSLNSIQLPQATTTTTTATSPSTSTSTSTSTSPNSSSLSISDQDKQLKRKEKQHQIVIPKDVKDSVANQQQQQQQQQNGTTSPRNNESSVTAATTTTTSTTASITTNVNTIPNFPPNKQLPATPTTGTPSTSTPTPQTPTSTSQNDKQNENNNKENFVDKQKTLGKLFSKFVHKKRTPLPGFDSSNSSSPSNNSNTTNSSSHSSTNSSPMETSPGVESPKITKSPSQNNILVDSLDIGSDNQQQQQDKLTTTTSTTTITINNNNNNNNNNNNNNNNNNNNIQQQQQQQQQIPTTPNKLSNSIAMNSSNRLMTPKKERSFTIGLVSGKHSCVVVETPKSKKLFQHESAKQILSIISMNFPSFEKEFQMQNSEVISNIIEQIGNVIKNYHDEVSESSSSSSSSTTSPNNINTPSDCSPILNSENSKDSHNLSSINNSSYDPVSPALRKMYENGSYDSKEHSRSSIQSKITRKLGTIRKKGPSPFNMLLNSSTGSLSSLYLDQLNGGNGDSSSSSSSSYNLVGGSGISGYDNQNEIDASEHLVSTSSLFTEEAIELVSKCFEASIIVNHSGGTSSEIKALFSSTLDHLESMLQSSVNFGKIDPSSFCMTFLKNIRQHIPTMKSKGGKCDPTLVTAATKLFRHTILSNLDKSIHSLCHSVRVLAIQMTIIVISISAKPWDISSQLQLFASAKSFIDSLVSLLDAVENKIYISTNTNIQDDVEVPTIDDTEDTNIWEEADSPLTFGWISDEGSKTGRYVPKAGTLNKLISALTQDNKHDISRYTKTFLLTYQSFTNPWKLMEKLIQRYNVPLDEKPDVRATTQLRVVSFMQTWIERNFNDFDDQLIGQLKEFRTRLLMDNNNDLAVILGGLIKKKEAERSLSKERSTNHLTFPELMIPDGQKSPTALFLLLNESEIARQLTLIDFNIFSKIQPTELLDQSWNKDSLKFKSPNVIEMINRANKFSFWVSSQILWQEDIEERVKVFEKFILISKYLREMNNFNTLLAIFTGLNTAPILRLKKTFALLSPNSLSIYNSLEKLMNSSGSYKNYRSVSKNPPLLPYLPVILSDLTFMEDGNPDKINNLINFQKRELICRVISEVQQCQQQTKYEFPVVEPIHTLLTELPSSTPSELYQLSLIREPRETNQSNANSSISSGSNFLSNSSNHNIGNNNGFDTLKKYYKSSNNN
What is the function of this protein?
Promotes the exchange of Ras-bound GDP by GTP.  May also play a role in the activation of rasG.
What are the official names of this protein?
Ras guanine nucleotide exchange factor R, RasGEF domain-containing protein R.
Protein: RPOA_PSEPU
Sequence: MQSSVNEFLTPRHIDVQVVSPTRAKITLEPLERGFGHTLGNALRRILLSSMPGCAVVEAEIDGVLHEYSAIEGVQEDVIEILLNLKGLAIKLHGRDEVTLTLSKKGSGVVTAADIQLDHDVEIVNPDHVIANLASNGALNMKLVVARGRGYEPADSRQSDEDESRSIGRLQLDSSFSPVRRIAYVVENARVEQRTNLDKLVIDLETNGTLDPEEAIRRAATILQQQLAAFVDLKGDSEPVVVEQEDEIDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLDNWPPASLKKDDKATA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: OGG1_AQUAE
Sequence: MDAIQEVKRIIPEVQKYVNQRMEEFERLGREGWTHFDFRPFLDIDYDAGLFSELSFCILTANSSATLGIKIQAHLGEEGFLNKTKEELEEVFRKFGHRYAGQRAERIVEAREKFPKVKSLIEKEKNSKVIRELLADPKSPYKIKGFGYKEASHFLRNIGFKDLAIIDRHISRFLMEKGLLRQVKSITPKVYLEAEKALESLAKELGLSLGELDLYIFYIKTKKVLK
What is the function of this protein?
Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA.  Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).
What are the official names of this protein?
8-oxoguanine DNA glycosylase/AP lyase.
What is the protein family that this protein belongs to?
Belongs to the type-2 OGG1 family.