PharMolix/UniProtQA huggingface dataset:
Protein: TGFA1_MOUSE
Sequence: MMNIKAFTLVSAVERELLMGDRDHISIECVECCGRNLYVGTNDCFIYHFLLEEKAMPTGTATFVATKQLHRHLGFKKPVNELCAASALNRLLVLCDNSITLVNMLNLEPVPSGARIKGATTFAVNESPVNGDPFCVEVCIISVKRRTVQMFLVYEDRVQIVKEVSTPEQPLAVAVDGYFLCLALTTQYIILNYSTGLSQDLFPYCSEEKPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVCFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLANRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKELFRSSQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKRFLMSYLNEIRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIVNGDIQDSTRSDLYEYIVDFLTYCLDQELVWTHADWLLQKSEEIGVQIFTKRPLDEQQQTSFNPDNIISSLKKYPKALVKYLEHLVIDRRLQKEEYHTHLAILYLEEVLRQRVSTGGKDVEATETQAKLRRLLQKSDLYRVHLLKEKVQGAGLPMESAILHGKLGEHEKALHILVHEMGDFSAAEDYCLWSSEGQGAACRQRLFHTLLAMYLRAGPSAQDLTVAAVDLLNHHAREFDVTQVLQLLPDTWSVQLLCPFLMGAMRDSIHARRTTQVALGLAKSENLIYMYDKMKLKGNAVRLSERELCQLCQNPFGEPVFVRYPNGGLVHTHCAASRHTAPSSPSPGTRT
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway.  Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion.  The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations.  Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (By similarity).
What are the official names of this protein?
Transforming growth factor-beta receptor-associated protein 1, TGF-beta receptor-associated protein 1, TRAP-1, TRAP1.
What is the protein family that this protein belongs to?
Belongs to the TRAP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome. Note=Colocalizes with TGF-beta receptors in the absence of signaling.
Protein: MIAB_PROA2
Sequence: MTKKVSIRTFGCQMNQADTEIISSLLTAEGYCLVAEEDDADLVMLNTCAVRENAVEKIMHHLDSLKGLRRRRRGLVVGVIGCVPQYYREEMFQKSGVIDFIAGPDSYRKLPGLIRNAFQGIRGAELFLTQSETYGDIEPMRSGSISAFIPVMRGCNNMCAFCVVPFTRGRERSRSLQSVLDEVRRLEGQGYRELTLLGQNVNSYRDDEAGADFALLLDEVSKAAGEMRVRFTTSHPKDISEDLVNVVAQRENVCNAIHLPVQSGSSRMLEVMHRGHTRREYLDKIAMIRSAVPGVALSTDLIAGFCGETEEDHLQTLSLMEEVRFDYAYMFYYSVRPGTYAARHLTDDVALEEKKRRLQEIIDLQSGISGEIFGNDVGSVQEVLAESESRRSSDMLMGRSDTNRVVVFDRQHYQPGDLVRVVIESSTQATLIGRCQDPGEG
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SODF1_ARATH
Sequence: MAASSAVTANYVLKPPPFALDALEPHMSKQTLEFHWGKHHRAYVDNLKKQVLGTELEGKPLEHIIHSTYNNGDLLPAFNNAAQAWNHEFFWESMKPGGGGKPSGELLALLERDFTSYEKFYEEFNAAAATQFGAGWAWLAYSNEKLKVVKTPNAVNPLVLGSFPLLTIDVWEHAYYLDFQNRRPDYIKTFMTNLVSWEAVSARLEAAKAASA
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Fe] 1, chloroplastic, Protein FE SUPEROXIDE DISMUTASE 1, FeSOD.
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
What are the subcellular locations of this protein?
Cell membrane. Plastid, chloroplast membrane. Plastid, chloroplast stroma.
Protein: FLIR_BUCBP
Sequence: MFQFNFNDFILFIYNLFFPAVRILALFSTAPLFNSKFIEKKIKLIMAFVISWIFSSFLPKVNIAIFSVDGILIIIEQMLIGILLGLTMQLIFSSIFMSGEIISLQMGLSFSSLFDFNSRSNLSALSHFVHIFLLLLFLEWNGHIWMLSALFDTFITIPIQKIYLDPNIFLKVVNFSKYIFFDSIMLLFPIIIVQLLLNLSIGILNRVAPQISILSLGFTVTLLVGIILLYFFIPIFPSSCIVIFRRLQSFVLTLFNS
What is the function of this protein?
Role in flagellar biosynthesis.
What are the official names of this protein?
Flagellar biosynthetic protein FliR.
What is the protein family that this protein belongs to?
Belongs to the FliR/MopE/SpaR family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Protein: GMHA_PELPD
Sequence: MLDDITTQLKSRRALFELIARDMPPLMADMAAQLVEAFRKGNKLLVMGNGGSAADAQHLAAEIVGRFKMERRALPAISLSTDSSILTALGNDYGFDAVFRRQVEALAQAGDVVLGISTSGNSPNVRSALQLARERGCRTMGLLGRDGGSIRSLCDLALVVPSLDTPTIQEGHITIIHIVCDLVEKALFA
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPNS3_ARATH
Sequence: MVTKEEDCLPPVTETTSRCYSTSSSTPLAELETVRSLEIVESSSSLSPVWLLVIFCIINLLNYMDRGAIASNGVNGSTRSCNDKGKCTLATGIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLAKRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMKPLQLKGSETLKNNNRLQVDNEIEHDQFEVSIETSKSSYANAVFKSFTGFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMKNADMIFGAVTIICGIVGTLSGGFILDRVTATIPNAFKLLSGATFLGAVFCFTAFTLKSLYGFIALFALGELLVFATQAPVNYVCLHCVKPSLRPLSMAISTVAIHIFGDVPSSPLVGIVQDHINSWRKTTLILTSILFLAAAIWFIGKINLNSFYSNDESFLVQIKLFVANLCFCKGYS
What is the function of this protein?
Probable sphingolipid transporter.
What are the official names of this protein?
Probable sphingolipid transporter spinster homolog 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GTPS_CITLI
Sequence: MALNLLSSLPAACNFTRLSLPLSSKVNGFVPPITQVQYPMAASTSSIKPVDQTIIRRSADYGPTIWSFDYIQSLDSKYKGESYARQLEKLKEQVSAMLQQDNKVVDLDPLHQLELIDNLHRLGVSYHFEDEIKRTLDRIHNKNTNKSLYARALKFRILRQYGYKTPVKETFSRFMDEKGSFKLSSHSDECKGMLALYEAAYLLVEEESSIFRDAIRFTTAYLKEWVAKHDIDKNDNEYLCTLVKHALELPLHWRMRRLEARWFIDVYESGPDMNPILLELAKVDYNIVQAVHQEDLKYVSRWWKKTGLGEKLNFARDRVVENFFWTVGDIFEPQFGYCRRMSAMVNCLLTSIDDVYDVYGTLDELELFTDAVERWDATTTEQLPYYMKLCFHALYNSVNEMGFIALRDQEVGMIIPYLKKAWADQCKSYLVEAKWYNSGYIPTLQEYMENAWISVTAPVMLLHAYAFTANPITKEALEFLQDSPDIIRISSMIVRLEDDLGTSSDELKRGDVPKSIQCYMHETGVSEDEAREHIRDLIAETWMKMNSARFGNPPYLPDVFIGIAMNLVRMSQCMYLYGDGHGVQENTKDRVLSLFIDPIP
What is the function of this protein?
Monoterpene synthase which catalyzes the conversion of geranyl diphosphate to gamma-terpinene and the minor products limonene, alpha-pinene, beta-pinene, alpha-terpinolene, alpha-thujene, alpha-terpinene, myrcene and sabinene.
What are the official names of this protein?
Gamma-terpinene synthase, chloroplastic, ClgammaTS.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CSK2B_YEAST
Sequence: MSQEFVEDYSRTGSSDDEDSGAYDEWIPSFCSRFGHEYFCQVPTEFIEDDFNMTSLSQEVPHYRKALDLILDLEAMSDEEEDEDDVVEEDEVDQEMQSNDGHDEGKRRNKSPVVNKSIIEHAAEQLYGLIHARFILTKPGLQAMAEKFDHKEFGTCPRYYCNGMQLLPCGLSDTVGKHTVRLYCPSCQDLYLPQSSRFLCLEGAFWGTSFPGVFLKHFKELEEYVERKSKESYELKVFGFRINDEAVSGPRMKWLRQYPSTEEDWEEFAKCEFETPAV
What is the function of this protein?
Regulatory subunit of casein kinase II/CK2 (By similarity).  As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity).
What are the official names of this protein?
Casein kinase II subunit beta, CK II beta.
What is the protein family that this protein belongs to?
Belongs to the casein kinase 2 subunit beta family.
Protein: FUCI_STRPJ
Sequence: MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLKYPDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIPHAIWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEANDTDIPEDVKEKLLRYARAALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRGIYDPEEFERAMVWVKEHIKEGVDRNREDLILSKEEKEKQWEFVIKMFMIGRDLMVGNPRLAELGFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFATENDSLNGVSMLFNYLLTNTPQIFADVRTYWSPEAVERVTGYTLEGRAAAGFLHLINSGSCTLDGTGQATRDGKPVMKPFWELDESEVQAMLENTDFPPANREYFRGGGFSTRFLTKGDMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPTTWFAPRLTGKGAFKSVYDVMNNWGANHGAITYGHIGADLITLASMLRIPVNMHNVPEEDIFRPKNWSLFGTEDLESADYRACQLLGPLHK
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
What are the official names of this protein?
L-fucose isomerase, 6-deoxy-L-galactose isomerase, FucIase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BH094_ARATH
Sequence: MPLEAVVYPQDPFGYLSNCKDFMFHDLYSQEEFVAQDTKNNIDKLGHEQSFVEQGKEDDHQWRDYHQYPLLIPSLGEELGLTAIDVESHPPPQHRRKRRRTRNCKNKEEIENQRMTHIAVERNRRKQMNEYLAVLRSLMPSSYAQRGDQASIVGGAINYVKELEHILQSMEPKRTRTHDPKGDKTSTSSLVGPFTDFFSFPQYSTKSSSDVPESSSSPAEIEVTVAESHANIKIMTKKKPRQLLKLITSLQSLRLTLLHLNVTTLHNSILYSISVRVEEGSQLNTVDDIATALNQTIRRIQEET
What are the official names of this protein?
Transcription factor bHLH94, Basic helix-loop-helix protein 94, AtbHLH94, bHLH 94, Transcription factor EN 16, bHLH transcription factor bHLH094.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLDS3_SALSC
Sequence: MTSVNLSRAPAAITRRRLQLQPEFHAECSWLKSSSKHAPLTLSCQIRPKQLSQIAELRVTSLDASQASEKDISLVQTPHKVEVNEKIEESIEYVQNLLMTSGDGRISVSPYDTAVIALIKDLKGRDAPQFPSCLEWIAHHQLADGSWGDEFFCIYDRILNTLACVVALKSWNLHSDIIEKGVTYIKENVHKLKGANVEHRTAGFELVVPTFMQMATDLGIQDLPYDHPLIKEIADTKQQRLKEIPKDLVYQMPTNLLYSLEGLGDLEWERLLKLQSGNGSFLTSPSSTAAVLMHTKDEKCLKYIENALKNCDGGAPHTYPVDIFSRLWAIDRLQRLGISRFFQHEIKYFLDHIESVWEETGVFSGRYTKFSDIDDTSMGVRLLKMHGYDVDPNVLKHFKQQDGKFSCYIGQSVESASPMYNLYRAAQLRFPGEEVLEEATKFAFNFLQEMLVKDRLQERWVISDHLFDEIKLGLKMPWYATLPRVEAAYYLDHYAGSGDVWIGKSFYRMPEISNDTYKELAILDFNRCQTQHQLEWIHMQEWYDRCSLSEFGISKRELLRSYFLAAATIFEPERTQERLLWAKTRILSKMITSFVNISGTTLSLDYNFNGLDEIISSANEDQGLAGTLLATFHQLLDGFDIYTLHQLKHVWSQWFMKVQQGEGSGGEDAVLLANTLNICAGLNEDVLSNNEYTALSTLTNKICNRLAQIQDNKILQVVDGSIKDKELEQDMQALVKLVLQENGGAVDRNIRHTFLSVSKTFYYDAYHDDETTDLHIFKVLFRPVV
What is the function of this protein?
Involved in the biosynthesis of labdane-type diterpenoid including sclareol, a diterpene-diol that is used as fragrance and flavoring, and has anticancer effects (able to kill leukemic and colon cancer cells by apoptosis) (Probable).  Sclareol can also be used as synthesis precursor of ambergris substitution fragance products such as ambrox (Probable).  Terpene synthase that produces 8-hydroxycopalyl diphosphate from geranylgeranyl diphosphate (GGPP) (PubMed:23113661, PubMed:22959531).
What are the official names of this protein?
Copal-8-ol diphosphate hydratase TPSSA3, chloroplastic, 8-hydroxycopalyl diphosphate synthase, 13-labden-8,15-diol pyrophosphate synthase TPSSA3, SsLPS, Diterpene synthase 1, chloroplastic, SscTPS1, Diterpene synthase Sa3, SsTpsSa3.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: QTRT2_DROSE
Sequence: MKFAIESISKNSGRLGQLRIKDGGPEFKTPLLLQTTKGGSIPWLSADVFETQVSRKPQVLQFTLSTMEQMTEALTHWNSGGGRGLSDYVGLPGHLNILLLRDPCETTPSGGNDRDILPLFTRRGKESLSAERYMEIVASFKPDMYEGLCDADTNLESAKKRVQKSVDRTEKFMHYIYEHRGKVNSTLLAPIVGGYNTFARTQSIKHAREQPAGSYGGYIFEGFHTNGLSATTLDTSELLPIVEHCVKQLEEDKPRILPGAYTPLTILELIQQGIDVFDTSYAYCASLNFKALTFSFVQDAVEHVPFLDITDEAIKEDFNPPLSNCNCLTCQKHTRAYLHHLYKTNELLGPILLMVHNLYHYMDFFEKIRESVAKDTLPQLTELVRNQNGKTQVDYSIAANTKVISKATMEKGFAAAAV
What is the function of this protein?
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase accessory subunit 2, Queuine tRNA-ribosyltransferase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_BORA1
Sequence: MQLNPSEISELLKSRIEGLGASTDVRTQGTVVSVTDGITRIHGLSDVMQGEMLEFPNNVFGLALNLERDSVGAVILGDYTGVSEGDQVKTTGRILEVPVGPELRGRVVNTLGLPIDGKGPINTKETDIIEKVAPGVIARRSVSQPLQTGIKAIDSMVPIGRGQRELIIGDRQTGKTAVAVDTIISQKGKGVTCVYVAIGQKASTINNVVRKLEEHGAMEYTIVVAASASDSAAMQYLAAYAGCTMGEYFRDRGEDALIIYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNEEYVEKFTNGAVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETDLFNAGVRPAINAGISVSRVGGAAQTKVVKKLSGGIRTDLAQYRELAAFAQFASDLDDATRRQLERGKRVVELLKQPQYQPLQVWELAVSLYTVNNGYLDDVDVAQVLSFEKSLKDQLKAKHAALIQRIEDTKELSKDDEAELAAAVQDFKKHGAF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PPE33_MYCTU
Sequence: MDFGLQPPEITSGEMYLGPGAGPMLAAAVAWDGLAAELQSMAASYASIVEGMASESWLGPSSAGMAAAAAPYVTWMSGTSAQAKAAADQARAAVVAYETAFAAVVPPPQIAANRSQLISLVATNIFGQNTAAIAATEAEYGEMWAQDTMAMFGYASSSATASRLTPFTAPPQTTNPSGLAGQAAATGQATALASGTNAVTTALSSAAAQFPFDIIPTLLQGLATLSTQYTQLMGQLINAIFGPTGATTYQNVFVTAANVTKFSTWANDAMSAPNLGMTEFKVFWQPPPAPEIPKSSLGAGLGLRSGLSAGLAHAASAGLGQANLVGDLSVPPSWASATPAVRLVANTLPATSLAAAPATQIPANLLGQMALGSMTGGALGAAAPAIYTGSGARARANGGTPSAEPVKLEAVIAQLQKQPDAVRHWNVDKADLDGLLDRLSKQPGIHAVHVSNGDKPKVALPDTQLGSH
What are the official names of this protein?
Uncharacterized PPE family protein PPE33.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: SYDND_PROA2
Sequence: MSLAPGTETDLQNRFRSHFCGRLNTEYENKQVRLAGWIHRKRDHGGLIFIDLRDHTGIAQLIIQPEKQELFQKVERLHVESVIAVQGTVVKRSEETLNSRIPSGAIEVLVDDVQVESHAVALPFPVADELQTSEELRLTYRFLDLRREKIHQNIVFRSQLISKVRRYLEDHGFMEIQTPILTASSPEGARDFLVPSRLHPGKFYALPQAPQQFKQLLMVSGFPRYFQIAPCFRDEDARADRSPGEFYQVDMEMAFIEQDDLFEILEGMLRYLTETMSTKRITQFPFPRLSYRDVMNRFGSDKPDLRVPLEMQDVTELFVGSSFKVFASNTKEGSCIKAMVLKGRGTESRQFYDKAEKRARELGAPGLAYVQYREEGPKGPIVKFLSEAELSALQERLAIETGDVVFFGAGKWEKTCKIMGGIREYFSDLFELDRDELSFCWIVDFPLYEFDEKESRIDFSHNPFSMPQGEMDALDTMNPLDILAYQYDIVCNGIELSSGAIRNHRPDIMYRAFEIAGYSKEEVDKRFGHMIEAFKMGAPPHGGIAPGLDRLVMILRDEHNIREVIAFPMNQQAQDLMMSAPSDVSRLQLRELHLKLDLPVETAEQEPG
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YRHD_ECOLI
Sequence: MEKLTTELHSLSEMDRRHVVSILAEIANGYDDFNDMLIYLEFYPNHKILIS
What are the official names of this protein?
Protein YrhD.
Protein: IRAK1_MOUSE
Sequence: MAGGPGPGEPVVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSEQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPVVPPSTAAPRPSSISAGSEAGDWSPRKLQSSASTFLSPAFPGSQTHSESELLQVPLPVSLGPPLPSSAPSSTKSSPESPVSGLQRAHPSPFCWPFCEISQGTCNFSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQRAVRTQGAKTKYLKDLIEDEAEEAGVTLKSTQPTLWVGVATDAWAAPIAAQIYKKHLDSRPGPCPPQLGLALAQLACCCMHRRAKKRPPMTQVYKRLEGLQAGPPWELEVAGHGSPSPQENSYMSTTGSAQSGDEPWQPLVVTTRAPAQAAQQLQRSPNQPVESDESVPGLSATLHSWHLTPGSHPSPASFREASCTQGGTTRESSVRSSPGFQPTTMEGSPTGSSSLLSSEPPQIIINPARQKMVQKLALYEEGVLDSLQLLSSGFFPGLDLEPEKSQGPEESDEFQS
What is the function of this protein?
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.  Involved in Toll-like receptor (TLR) and IL-1R signaling pathways.  Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation.  Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation.  Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1.  Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex.  In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation.  Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation.  Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state.  When sumoylated, translocates to the nucleus and phosphorylates STAT3 (By similarity).
What are the official names of this protein?
Interleukin-1 receptor-associated kinase 1, IRAK, IRAK-1, Pelle-like protein kinase, mPLK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Lipid droplet. Note=Translocates to the nucleus when sumoylated (By similarity). RSAD2/viperin recruits it to the lipid droplet.
Protein: Y6963_RHOBA
Sequence: MTAAPASVRLFQTHEMEALRRDRRLDPQVFRKLRNDLLKKFESDEAVLEKYPVAEAIELHSLKLYQRMDSEIDGATKLLFETESGMLIESVILRIATGRTTLCVSSQIGCAAACDFCATGKMGIAKNLATEEILDQVVQAGQILRGEDRRLSNIVFMGMGEPLHNEVNVTEAIELLTAPDHFARSPSTVLVSTVGVPAGMLRLAKRFPNLNLALSLHSADQTTREKIIPLGKKASLAQLHDAIHEIQTIQDREFMIEYLMLRDVNDSAKDADRLIDWIGDLRVHVNLIPYNTIEASPHLHASSRPVIESFADILKASGLKTTVRYSLGNDIEAACGQLIRQENRQRAMQARRTESESDSHVGFLDVRQVVDGLESQKNK
What are the official names of this protein?
Probable RNA methyltransferase RB6963.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCR2_ORYSJ
Sequence: MGSSSLLLFPSSSSSATHSSYSPSSSSHAITSLLPPLPSDHHLLLYLDHQEQHHLAAAMVRKRPASDMDLPPPRRHVTGDLSDVTAAAAGAPTLSASAQLPALPTQLPAFHHTDMDLAAPAPPAPQQVAAGEGGPPSTAWVDGIIRDIIASSGAAVSVAQLIHNVREIIRPCNPDLASILELRLRSLLNSDPAPPPPPPSHPALLPPDATAPPPPPTSVAALPPPPPAQPDKRRREPQCQEQEPNQPQSPKPPTAEETAAAAAAAAAAAAAAAKERKEEQRRKQRDEEGLHLLTLLLQCAESVNADNLDEAHRALLEIAELATPFGTSTQRVAAYFAEAMSARLVSSCLGLYAPLPSPSPAGARVHGRVAAAFQVFNGISPFVKFSHFTANQAIQEAFEREERVHIIDLDIMQGLQWPGLFHILASRPGGPPRVRLTGLGASMEALEATGKRLSDFADTLGLPFEFCPVADKAGNLDPEKLGVTRREAVAVHWLRHSLYDVTGSDSNTLWLIQRLAPKVVTMVEQDLSHSGSFLARFVEAIHYYSALFDSLDASYSEDSPERHVVEQQLLSREIRNVLAVGGPARTGDVKFGSWREKLAQSGFRVSSLAGSAAAQAALLLGMFPSDGYTLIEENGALKLGWKDLCLLTASAWRPIQASGR
What is the function of this protein?
Probable transcription factor involved in asmmetric cell division in the cortex/endodermis progenitor cell and in the process of stomata and ligule formation in leaves.
What are the official names of this protein?
Protein SCARECROW 2, OsSCR2.
What is the protein family that this protein belongs to?
Belongs to the GRAS family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized around the dividing nucleus during asymmetric division.
Protein: AROC_FLAPJ
Sequence: MSGNSYGKIFKITTFGESHGEALGGIIDGCPPNIILDLDAIQIEMQRRKPGQSSIVTQRKEADEVQFLSGIFEGKTTGTPIGFIIKNTNQKSDDYSHIKDSYRPSHADYVYEKKYRIRDYRGGGRSSARETASRVVAGAIAKQVIPEIKINAFVSSVGDISLDKPYQDLNFSLTETNAVRCPDLASAEKMENYIKEIKKQGDTVGGTITCVIQNVPIGLGEPVFDKLHAELGKAMLSINAVKGFEYGSGFCGAKMKGSNHNDPYNQDGTTRTNLSGGIQGGISNGMDIYFRIAFKPVATLIQKQEVLTNTNEIIEQQGKGRHDPCVVPRAVPIVEAMAAIVMADFFLLNKIYNNH
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RHLB_XANC5
Sequence: MSDKPLTDVTFSSFDLHPALIAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLIRPALADRKPEDPRALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICVLDEADRMFDLGFIKDIRFLLRRMPERGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETESITAARVRQRIYFPSDEEKQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIEAYIEQKIPVEPVTSELLTPLPRAPRVPVEGEEADDDAGDSVGTIFREAREQRAAEEQRRGGGRSGSGGSRSGSGGGGGRREGAGADGKPRPRRKPRVEGQAPATAASTEHPVVAAAAGQAPSAGVADAERAPRKRRRRRNGRPVEGAEPAVASTPVPAPAAPRKPTQVVAKPVRAAAKPSGSPSLLSRIGRRLRSLVSGN
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_GRAFK
Sequence: MARILALDYGTKRTGVAVTDELKMIASGLTTVQTPELIKFLEDYFKNEKVERVLVGEPKRMDDTPSQSEVHIQEFLKEFVKKFPEMPMERVDERFTSKMAVQSMIDGGLKKKKRRDKALVDEISATIILQTWLYE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_AZOVD
Sequence: MPIHEIRHPLIRHKLGLMRRADISTKSFRELAQEVGALLTYEATKDLPLENYRIEGWCGPVEVEKIAGKKITVVPILRAGIGMLDGVLRLIPNAKVSVVGLSRDEETLVAHTYVEKLVGEIDQRLALIVDPMLATGGSMAATVDMLKKAGCKEIRALVLVAAPEGIRLLERTHPDVTIYTAAIDQRLNENGYIIPGLGDAGDKVFGTKQKPS
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.