PharMolix/UniProtQA huggingface dataset:
Protein: RS12_ACIAD
Sequence: MATTNQLIRKGRTTLVEKSKVPALKACPQRRGVCTRVYTTTPKKPNSAMRKVCRVRLTSGFEVSSYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGSLDCAGVKDRNQSRSKYGTKRPKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: LOLA_KLEP7
Sequence: MKKLAITCALLSGMVVSQVWADAASDLKSRLDKVSSFHASFTQKVTDGSGNAVQDGQGDLWVKRPNLFNWHMTQPDESVLVSDGKTLWFYNPFVEQATATWLKDATSNTPFMLIARNQSSDWQQYNIKQNGDDFVLTPKSGSGNLKQFTINVGRDGTIHQFSAVEQDDQRSSYQLKSQQNGAVDAAKFTFTPPKGVTVDDQRK
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: KLK15_SAGOE
Sequence: MWLLLPLSFLLTSTAQDGGKLLEGEECAPHSQPWQVALYERGRFNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTASRVIPHPRYEARSHRHDIMLLRLVQPARLTPQVRPVVLPTRCPHPGEACVVSGWGLVSHNEPGTTGRPQSQVSLPDTLHCANISIISDASCDKNYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVYTKVCRYVKWIRETMKRN
What is the function of this protein?
Protease whose physiological substrate is not yet known.
What are the official names of this protein?
Kallikrein-15.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Kallikrein subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FIBG_PETMA
Sequence: MGRIGTPVFLAFLSALTCSLQVHAQVRDLKQCSNDPEFGRYCPTTCGVADVLSKYAKGVDEDSSFIDSVLTQLAAKHGIVEGNVNIVNEDVRITRDEAQIIKDSGQKTVQKILEEVRILEQIGVSHDAQIQELSEMWRVNQQFVTRLQQQLVDIRQTCSRSCQDTTANKISPITGKDCQQVVDNGGKDSGLYYIKPLKAKQPFLVFCEIENGNGWTVIQHRHDGSVNFTRDWVSYREGFGYLAPTLTTEFWLGNEKIHLLTGQQAYRLRIDLTDWENTHRYADYGHFKLTPESDEYRLFYSMYLDGDAGNAFDGFDFGDDPQDKFYTTHLGMLFSTPERDNDKYEGSCAEQDGSGWWMNRCHAGHLNGKYYFGGNYRKTDVEFPYDDGIIWATWHDRWYSLKMTTMKLLPMGRDLSGHGGQQQSKGNSRGDN
What is the function of this protein?
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix.  Has a major function in hemostasis as one of the primary components of blood clots.
What are the official names of this protein?
Fibrinogen gamma chain.
What are the subcellular locations of this protein?
Secreted.
Protein: RL19_JANSC
Sequence: MNLIAQLEAEQVEALAKDIPDFKAGDTVRVGFRVTEGTRTRVQNYEGVCIARKNGHGIAGSFTVRKISFGEGVERVFPLHSTNIDSITVIRRGRVRRAKLYYLRSRRGKSARIAEDTRYKPRKSASA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: MVP_PPVNA
Sequence: MSTIVFGSFTCHLDAAIHQDNADRLAKAWTRPENRQVSNAHLLCRRAAESLINTYESATASAWKGLEEKLQPMFAKREFSKTVTKRKGLRCFKESSEKFIEKKLRKQYQEERERLQFLNGPDAIVNQISVDKCEASVRVPSPHIIEKPSFVTPSMKKKVVFKKVRMSEASLQLFMRRVAANAKANGQKVEIIGRKRVVGNYTTKSRLTYFRTHVRHLDGSKPRYDLVLDEATKKILQLFANTSGFHHVHKKGEVTPGMSGFVVNPMNLSDPMQVYDTDLFIVRGKHNSILVDSRCKVSKKQSNEIIHYSDPGKQFSDGFTNSFMQCKLRETDHQCTSDLDVKECGYVAALVCQAIIPCGKITCLQCAQKYSYMSQQEIRDRFSTVIEQHEKTVMDNYPQFSHVLAFLKRYRELMRVENQNYEAFKDITHMIGERKEAPFSHLNKINELIIKGGMMSAQDYIEASDHLRELARYQKNRTENIRSGSIKAFRNKISSKAHVNMQLMCDNQLDTNGNFVWGQREYHAKRFFRNYFDVIDVSEGYRRHIVRENPRGIRKLAIGNLVMSTNLAALRKQLLGEECIHFEVSKECTSKRGENFVYQCCCVTHEDGTPLESEIISPTKNHLVVGNSGDSKYVDLPTAKGGAMFIAKAGYCYINIFLAMLININEDEAKSFTKTVRDTLVPKLGTWPSMMDLATACHFLAVLYPETRNAELPRILVDHEAKIFHVVDSFGSLSTGMHVLKANTINQLISFASDTLDSNMKTYLVGGLEVDKCDEFKNVKLLIRSIYKPQIMEQVLKEEPYLLLMSVLSPGVLMALFNSGSLEKATQYWITRSHSLAAITSMLSALAAKVSLASTLNAQMSVIDEHAAVLYDSVFVGTQPYASYMMAVKTLERMKARTESDHTLNDLGFSVLRQATPHLVEKKLSPGIGASLERVKLVGKILCNLGIAAMAKTYTKTFHPKRRRRFRRQVRHLRSVITWQPVQTPERRSPMEKRRCGLLYIPVDGEAILQSHRNLTKFSS
What is the function of this protein?
Allows efficient cell to cell propagation, by bypassing the host cell wall barrier.  Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding (By similarity).
What are the official names of this protein?
P3N-PIPO polyprotein.
What is the protein family that this protein belongs to?
Belongs to the potyviridae P3N-PIPO polyprotein family.
What are the subcellular locations of this protein?
Host cell junction, host plasmodesma.
Protein: BM23_DROME
Sequence: MKCLILSFAIFVVLASQATAGNVIIGGVCQDCSPPVAENVVVGGQSYRTGRPGQGTVYINSPGAYLGALDGPIRRTGAGGGGGGGAQYPDGYSGRLPGGTYLHNKDCVGCSISGGGD
What is the function of this protein?
Secreted immune-induced peptide induced by Toll signaling (PubMed:9736738).  Has a role in resistance to bacterial and fungal infections (PubMed:25915418, PubMed:29920489).
What are the official names of this protein?
Bomanin Bicipital 1, Bomanin-23, Immune-induced peptide 23, DIM-23, DIM23.
What is the protein family that this protein belongs to?
Belongs to the bomanin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRF_NOSS1
Sequence: MSNDKIIVALDVPDTESAIALIDKLESVTFWKVGLELFTSSGPRILEVLKSRQKRIFLDLKFHDIPNTVAGACRAAAGYGVDLMTIHATSGRDALKAAKEAVEEGAAQAGVKPPKLIAVTVLTSISARQLALDLKIPSELPEYALDMALMAQEMGLDGAVCSPQEVAHLRQICGDDFVLVCPGVRPTWAEAGDQKRSLTPSQAIQAGADYLVIGRPITAAAEPELAWKRISQELTTVV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: PROB_PSEU2
Sequence: MRSKVTGAQRWVVKIGSALLTADGKGLDRNAMGVWVEQMVALHEAGVELVLVSSGAVAAGMSRLGWTARPSAMHELQAAAAIGQMGLVQAWESSFAEHGRHTAQILLTHDDLSDRKRYLNARSTLRTLVELGVVPVINENDTVVTDEIRFGDNDTLAALVANLVEADLLVILTDRDGMFDADPRNNPEAQLIYEARADDPALDAVAGGTGGALGRGGMQTKLRAARLAARSGAHTVIVGGRIERVLARLKGGERLGTLLSPERGMLAARKQWLAGHLQTRGTLVLDDGAVAALARDQKSLLPVGVKLVQGSFRRGEMVVCVAQDGREIARGLSNYSAIEAQKIIGHSSESIVRELGYMAEPELIHRDNLILV
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJDP_SHIBS
Sequence: MKRFPLFLLFTLLTLSTVPAQADIIDDTIGNIQQAINDAYNPDRGRDYEDSRDDGWQREVSDDRRRQYDDRRRQFEDRRRQLDDRQRQLDQERRQLEDEERRMEDEYGR
What are the official names of this protein?
Uncharacterized protein YjdP.
Protein: GCSH_STRAW
Sequence: MSNPQQLRYSKEHEWLSGAEDGVSTVGITEHAANALGDVVYVQLPEVGDTVTAGETCGELESTKSVSDLYSPVTGEVVEANQDVVDDPSLVNSAPFEGGWLFKVRVAEEPKDLLSADEYTEFSGS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: PP171_ARATH
Sequence: MRFSPTFFLLSQLRLTRRRAATSSRFYAVSALNNPNNLSDSEQQQVNHLNLSKLTQHGLQRLLNSTRDDPNLALSFLRQLKEHGVSPNVNAYATLVRILTTWGLDIKLDSVLVELIKNEERGFTVMDLIEVIGEQAEEKKRSFVLIRVSGALVKAYVSLGMFDEATDVLFQSKRLDCVVDIKACNFLMNRMTEFGKIGMLMTLFKQLKQLGLCANEYTYAIVVKALCRKGNLEEAAMLLIENESVFGYKTFINGLCVTGETEKAVALILELIDRKYLAGDDLRAVLGMVVRGFCNEMKMKAAESVIIEMEEIGFGLDVYACLAVIDRYCKNMNLPEALGFLDKMLGKGLKVNCVIVSLILQCYCKMDMCLEALEKFKEFRDMNIFLDRVCYNVAFDALSKLGRVEEAFELLQEMKDRGIVPDVINYTTLIDGYCLQGKVVDALDLIDEMIGNGMSPDLITYNVLVSGLARNGHEEEVLEIYERMKAEGPKPNAVTNSVIIEGLCFARKVKEAEDFFSSLEQKCPENKASFVKGYCEAGLSKKAYKAFVRLEYPLRKSVYIKLFFSLCIEGYLEKAHDVLKKMSAYRVEPGRSMCGKMIGAFCKLNNVREAQVLFDTMVERGLIPDLFTYTIMIHTYCRLNELQKAESLFEDMKQRGIKPDVVTYTVLLDRYLKLDPEHHETCSVQGEVGKRKASEVLREFSAAGIGLDVVCYTVLIDRQCKMNNLEQAAELFDRMIDSGLEPDMVAYTTLISSYFRKGYIDMAVTLVTELSKKYNIPSESFEAAVKSAALKAKRFQYGE
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g26790, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ATPD_PSEPK
Sequence: MAELTTLARPYAKAAFEHAQAHQQLANWSAMLGLAAAVSQDDTMQRLLKAPRLTSAEKAATFIDVCGDKFNAQAQNFIHVAAENDRLLLLPEIAALFDLYKAEQEKSVDVEVTSAFALNQEQQDKLAKVLSARLGQEVRLHASEDASLIGGVVIRAGDLVIDGSVRGKIAKLAEALKS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ACPS_RHIEC
Sequence: MIIGIGSDLIDIRRVEKSIERFGERFTHRCFTEVERARSDRRANRAASYAKRFAAKEACSKALGTGIAQGVFWKDMGVVNLPSGKPTMQLTGTAAVLLEAILPAGHRAAIHLTITDDYPLAQAFVIIEALPESP
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFB_RHOCS
Sequence: MTKSELILRLAERNPHLYQRDVEKIVTTIFDEITDALARGDRVELRGFGAFSVKKRDARLGRNPRTGETVDVNQKFIPFFKTGKQLRERLNTD
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PK1IP_CHICK
Sequence: MELVAGCYEQILFGFAARPGEPWTVTPDFTHHAHTASLSAVAVNSKYVVTGSRDESIQIYDMRKKVEHGALLQHNGTITCLEFYGTAHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNLKQNAHIIKWSPDGEKYVTVITNKVDIYKLDTASITGTITIEKRISSIRFITDSVLAIAGDDEIIRFYSCDSQKCLCEFKARENRIKDIYSFEREGQHVIVTASSDGYIKVWNLDLNKINNVPSLLCEVSTKARLTCLAVWLDQASEMKENCGKAATSTEANESEKPSAVKKKKVCGMNKSGKLTKQRRRIVPAKRKLEAPLQKKKKKKQNSSE
What is the function of this protein?
Negatively regulates the PAK1 kinase.  PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA.  PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain.  PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42.  May be involved in ribosomal large subunit assembly.
What are the official names of this protein?
p21-activated protein kinase-interacting protein 1-like, PAK1-interacting protein 1-like.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DER_PROMM
Sequence: MARPIVAIIGRPNVGKSTLVNRLCRSREAIVDDKPGVTRDRTYQDGFWGDREFKVVDTGGLVFDDDSEFLPEIREQANLALAEASVALVIVDGQQGVTAADESIAEWLRTQPCPTLVAVNKCESPDQGLAMAAEFWRLGLGEPFPISAIHGAGTGDLLDRVLSLLPPKHEEPEEDEPIQMAIIGRPNVGKSSLLNAICGEPRAIVSPIRGTTRDTIDTRLEREGHPWRLIDTAGIRRRRSVNYGPEFFGINRSFKAIERSDVCVLVIDALDGVTEQDQRLAGRIEDDGRACVLVVNKWDAVEKDSHTMPMVEKELRAKLYFLDWATMLFTSALTGQRVESIFALASLAVEQHRRRVSTSVVNEVLKEALSWRSPPTSRGGRQGRLYYGTQVASRPPSFTLFVNDPKLFGDTYRRYVERQLREGLGFDGTPLKLFWRGKQQRAAERELARQQNRLG
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: RNH2_BURCM
Sequence: MTAIRVPRRRASADLQGGFDFSRPDEIVCGVDEAGRGPLAGPVVAAAVILDPARPIDGLDDSKALSAKKRDALYDLIVARASAFCVASASVDEIDTLNILHATMLAMKRAVEGLSVLPTLAQIDGNRCPTLTVRAEAIVSGDALVPSISAASILAKVTRDRMLVDLHERFPVYGFNMHVGYSTPQHLAALREHGPCEVHRRSFAPVREALDLMAGSR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNA4_YEAST
Sequence: MCCYCVCCTVSDFILYIVAFFFPPAAVLLRSGPCSSDFLLNVLLTLLGFLPGMLHAFYYITITSPLRNAEYVYYYQQGWVDSERNVPSNRPQNSQTPQNRPQQGSSARNVYPSVETPLLQGAAPHDNKQSLVESPPPYVP
What are the official names of this protein?
Protein SNA4.
What is the protein family that this protein belongs to?
Belongs to the UPF0057 (PMP3) family.
Protein: SERP2_LACLM
Sequence: MNTNQNDENIEKQPSQRGLKNRHIQLIAIAGTIGTGLFLGAGKSIHLTGPSIIFVYLIIGALMYILLRAIGEMLYQDPSQHSFLNFVSRYMGAKPGYFIQWSYLLVVVFVAMAELIAIGTYINFWLPDLPIWMTEVFVLVLLTLLNTLNPKFFGETEFWFGMIKIVAIIGLILTAIILIFSHYHTGTDTVSLTNITKGFEFFPNGVSSFFESFQMVMFAFVSMEFIGMTAAETDNPRPTLKKAINQIPIRIVLFYIGALLAIMSIYQWRDIPADKSPFVTIFQLIGIKWAAALVNFVVLTSAASALNSALFSITRNLYSLSQLNDDKILKPFTKFSKAGVPVNALLFTSLLILFTPFISMIPAISNSFVFITSVATNLFLVVYLMTLITYLKYRKSKDFDPSGFTLPAAHIFIPLAIAGFVLIFISLFCFKDTIIPAIGSVIWVLIFGLFTFFRKIKTAD
What is the function of this protein?
Transports DL-alanine, DL-serine and glycine (PubMed:23144255, PubMed:25535271).  The preferred substrate is DL-alanine.  L-serine is a low-affinity substrate (PubMed:25535271).
What are the official names of this protein?
DL-alanine permease SerP2.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAIT_SALHS
Sequence: MKNEKKKSGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGDEKPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKEIGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMDVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMHLPRMLFYTDAIGKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTWILWTVLGSNTLLLMDKNILNIPQLIEQHGVARAIIETWAALPLSTATMWGFFILCFIATVTLINACSYTLAMSTCREVRDGEEPPLLVRIGWSVLVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKVHWKDK
What is the function of this protein?
Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.
What are the official names of this protein?
L-carnitine/gamma-butyrobetaine antiporter.
What is the protein family that this protein belongs to?
Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSBI_TETOB
Sequence: MLTLKVFVYTVVTFFVFLFIFGFLSNDPARNPGKGNLD
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CORZ_PRAMA
Sequence: QTFQYSRGWTN
What is the function of this protein?
Cardioactive peptide.  Corazonin is probably involved in the physiological regulation of the heart beat (By similarity).
What are the official names of this protein?
Corazonin.
What is the protein family that this protein belongs to?
Belongs to the corazonin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZD16A_DANRE
Sequence: MHPCSSVLHLLLRCMRGCCRHTRSRVPRRLRRHVSYIRLIFKSLYFNSLTNSDVVTDSILEPVFWMVEVVTRWFGMVFVFLVVALTSSVVFIAYFCLLPLVLHTYSPGWMIWHICYGHWNLVMIVFHYYKATKTPPGYPPKMKTDVPFVSVCKKCIIPKPARSHHCGICKTCILKMDHHCPWLNNCVGHFNHRYFFSFCLFLTLGCMYCSVSGRHLFIDAYNTIDQLKHLEAEKQGVPVTGIGLLIGIVPSAGVAGKAVQVAQEVSQPPYTYKDRMFHKSVIYMWVLTSTVSVALGALTLWHALLITRGETSIERHINGKEAKRLAKRGRVYRNPFSYGKLNNWKVFFGVEKRSHWLTRVLLPSGHAPYGDGLTWDIYPLKKDMMPV
What is the function of this protein?
Palmitoyl acyltransferase that mediates palmitoylation of proteins and is required during embryonic heart development.  Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).  Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (PubMed:26663717).
What are the official names of this protein?
Palmitoyltransferase ZDHHC16A, Zinc finger DHHC domain-containing protein 16A, DHHC-16A.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SECD_ENDTX
Sequence: MKINWKLLITVTLLAFSVWALWPSLKFALMSDEKKEQSEKERDPVLGRTLKLGLDLKGGTYLLLETDTSHLNGAVKVKDAVSRAIEIIRNRIDQFGVTEPMIAKQGDKWIVIQLPGIKDPKAAKDLIGKTALLEFRIVNTSEEARQVLDLIYEKRITPVQYRENSSAYPDIKAVMPEGASVFESRSNMDYYVLDKALLTGAALANAKVEFGGEYGQMMVSIEFNRDGGKIFEYITERNIGKSLAIVLDGIVQSAPVIRTRISRGERASIEGNFNSEDAKVLAAVLRAGALPVPVRLIEERTVGPSLGDDSIKKGFMSSLIGIVLVFLFMFIYYRSSGLIADVALSLNLIILMAIMAYLKFTLTLPGVAGIALTLAMSVDANVLILERIREEIAVGKTAKMAVDAGYQKVFWTIFDANFTTLIAALFLFQFGAGPIKGFAVTLSIGLIVSMFTAVTVTKLIYEFLFKKNLLLKIKI
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GET4_BOVIN
Sequence: MAAAAMAEQESARNGARNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMAQSKHAEARELMCSGALLFFSHGQQNSAADLSMLVLESLEKAEVEVADELLESLAKLFSLMDPNSPERVAFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYCESRYHFLHSSDGEGCANMLVEYSTARGFRSEVDMFVAQAVLQFLCLKNKSSASVVFTTYTQKHPSIEGGPPFVQPLLNFIWFLLLAVDGGKLTVFTVLCEQYQPSLRRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLSSLMGSSEQEGEDSQDDSSPIELD
What is the function of this protein?
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation.  The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane.  Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum.  Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome.  Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum.  The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome.  It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
What are the official names of this protein?
Golgi to ER traffic protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the GET4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: GLYA_STRTD
Sequence: MIFDKEDYKAFDPELWNAIDAEAERQQNNIELIASENVVSKAVMAAQGTLLTNKYAEGYPGKRYYGGTAVIDVVETLAIERAKKLFGAKFANVQPHSGSQANAAVYMSLIQPGDTVMGMDLSAGGHLTHGAPVSFSGKTYNFVSYNVDKESELLDYDAILAQAKEVRPKLIVAGASAYSRIIDFAKFREIADAVGAYLMVDMAHIAGLVASGHHPSPVPYAHVTTTTTHKTLRGPRGGLILTDDEDIAKKLNSAVFPGLQGGPLEHVIAAKAVALKEALDPAFKEYGENVIKNAAAMADVFNQHPDFRVISGGTNNHLFLVDVTKVVENGKVAQNVLEEVNITLNKNSIPYEQLSPFKTSGIRVGSPAITSRGMGEAESRQIAEWMVEALENHDKPEVLERIRGDVKVLTDAFPLY
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_HELHP
Sequence: MDYSIKEQDFEVFELIEKELERQNEHLEMIASENFTFPSVMEAMGSILTNKYAEGYPFKRYYGGCEFVDKIEEIAIERAKKLFGANFVNVQPHSGSQANAAVYAAILKPYDKILGMDLSHGGHLTHGAKVSTSGQLYQSFFYGVELNGRIDYDKLALQAQVVKPNVLVCGFSAYTRELDFKRLREIADSVGAYLMGDIAHVAGLVVAGEYPNPFPHCHIVTTTTHKTLRGPRGGAILTNDEELYAKINKAVFPGIQGGPLMHIIAGKAVGFKENLKPEWKIYAKQVKSNIQALAEVLIKRNYELVSGGSDNHLILMSFLNKDFSGKDADLALGNAGITVNKNTIPGEIRSPFITSGIRIGSPALTARGMKEKEFEWIGEKIADILDDINNTNLQEHIKAQVKNFSRDFRIYDRPIF
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.