PharMolix/UniProtQA huggingface dataset:
Protein: NTPPA_CLOBH
Sequence: MKNIILASASERRQELLKRILEDFQIIVSDFDESSAPFKDNIPSYVMNLAEGKARSVSKKIMDQDSNLVIGCDTLVAFNNKVLGKPKDKKDAFEMLQALSGNEHEVYSGLAILDVKSNKIITDFVCTKVKFSKLTSLQIEKYINTGDSMDKAGAYGIQGKAGVFVENINGCYYNVVGLPLNKLNSMLMEMGVNL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HADD_RHISH
Sequence: MIDLPRHPPSMLPVIRTVPEHAATGELKRRYDAVKSAFDVPWMGVVAMAHTQYPRFFDALWEGFEPIAGTRAFQDACRAMRAATEAGVERSLGISPLAHRLQDLGYDPREIGEIRTIIEVFSHGNYPYILLATVSRYLLSGGDLSGEPQVFETSPRSPHIFHQPILMEPHHADEHTRGIFADIQATLALPILNTDYRALARWPSYFHLAWAELRPLIRTPSHAALSQQLHEQAIAVLRTLPNPARLKGDMVTRGCGR
What is the function of this protein?
Catalyzes the hydrolytic dehalogenation of small (R)-2-haloalkanoic acids to yield the corresponding (S)-2-hydroxyalkanoic acids.  Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-2.
What are the official names of this protein?
(R)-2-haloacid dehalogenase, D-2-haloacid dehalogenase, D-DEX, D-specific mono chloro propionoic acid dehalogenase, DehIII.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
Protein: MTNA_MAGMM
Sequence: MSIFDVAVWDEAEHCARMLDQRRLPNEVVNLYYRSAAEMADGIRDMVVRGAPAIGCACAYGVAVEAKRLAKQGIPSHWPTAMAEGMATLRQSRPTAVNLTWALERMAPLLETTPPHEVPQRLLQEAHAIREEDIASCRAMGAHGAALLPTNSQRPTVIMTHCNAGALATAGYGTALGVIRAAHTAQQGNLRVIANETRPYLQGARLTAWELLQDHIDTTLITDNMAGWLMANGEVDAVVVGSDRVAANGDVANKIGTYTLAVLARRHDIPFFVAAPLSTVDLRCPTGREIPIEERSANEVTHCMGIRSAADGVKVRNPAFDVTPAELITAFICEKGVAKAPDQEKIAKLFQI
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: VKTL1_CYRHA
Sequence: MGIARILSAVLFLSVLFVVTFPTLLSADHHDGRIDTCRLPSDRGRCKASFERWYFNGTTCTKFVYGGYGGNDNRFPTEKACTKRCAKA
What is the function of this protein?
Serine protease inhibitor that inhibits trypsin and blocks voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type U15-theraphotoxin-Hhn1l, U15-TRTX-Hhn1l, Kunitz-type serine protease inhibitor hainantoxin-XI-12, HNTX-XI-12.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 01 (intermediate) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ERI1_HUMAN
Sequence: MEDPQSKEPAGEAVALALLESPRPEGGEEPPRPSPEETQQCKFDGQETKGSKFITSSASDFSDPVYKEIAITNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNYYKKQKLMLKESNFADSYYDYICIIDFEATCEEGNPPEFVHEIIEFPVVLLNTHTLEIEDTFQQYVRPEINTQLSDFCISLTGITQDQVDRADTFPQVLKKVIDWMKLKELGTKYKYSLLTDGSWDMSKFLNIQCQLSRLKYPPFAKKWINIRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPHCGLDDSKNIARIAVRMLQDGCELRINEKMHAGQLMSVSSSLPIEGTPPPQMPHFRK
What is the function of this protein?
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication (PubMed:14536070, PubMed:16912046, PubMed:17135487).  A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates (PubMed:14536070, PubMed:16912046, PubMed:17135487).  Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) (PubMed:14961122).  Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure (PubMed:14536070, PubMed:16912046).  Able to bind other mRNAs (PubMed:14536070, PubMed:16912046).  Required for 5. 8S rRNA 3'-end processing (By similarity).  Also binds to 5. 8s ribosomal RNA (By similarity).  Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs (PubMed:14536070, PubMed:17135487, PubMed:16912046).  In vitro, does not have sequence specificity (PubMed:17135487).  In vitro, has weak DNA exonuclease activity (PubMed:17135487).  In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (PubMed:17135487).
What are the official names of this protein?
3'-5' exoribonuclease 1, 3'-5' exonuclease ERI1, Eri-1 homolog, Histone mRNA 3'-end-specific exoribonuclease, Histone mRNA 3'-exonuclease 1, Protein 3'hExo, HEXO.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus.
Protein: OBG_RUTMC
Sequence: MKFVDSASIRIEAGKGGAGCLGFRREKYIPDGGPDGGDGGDGGHIYFQGQEGFNTLSEFRFKRLFRAKNGQPGSGQNKRGKSAQHLTVEIPLGTKIYDLETDELIGEMIEHEQIILVAKGGFHGLGNTRFKSSINRAPRKTTPGSPGEIREIGLELSIMADIGLLGMPNAGKSSLIRQISNAKSKVANYPFTTLHPSLGVVSYYDEHIIMADIPGLIENASKGVGLGFEFLKHLFHTKALLHVVDIFPVDGSDPVENFLTIEKELKKYDQKLAKKPRLLAINKMDLLSGGDRETVVQSLLKGTRYNGKVYRISALNGLGCKNLVAGLFKLVKENE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_PSE14
Sequence: MYAVIVTGGKQYKVAPGEYLKIEKLEIATGESVTFDRVLLVGNGDDVNIGAPVVAGATVVAEVVSQGRHDKVRIIKFRRRKHHMKRMGHRQWYTEIKITGIQA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: KEX1_PICGU
Sequence: MFFHAILVLIQVALALGASPRAGSSERSKYFVTSLPGMYSNLPKEEIPIMFSGQLELFPENNTHYYFWKFVNPNPIAEAERRTIFWLNGGPGCSSMDGALMEAGPFRVNDDKEIVYNNGSWHKAGDIVFVDQPAGTGFSYSDEYEHELPDVSVHFLKFLEKYFEVFPEDRQNQIFFAGESYAGQYIPYIADGILKRNKNLKAGESPYDLRGLLIGNGWIAPNEQSLSYVQYALQAGFVSPSMPGWSRLLASQERCQNVVNSVNTQDDSVSDYKVVSDVCDQVLNTLLEVARDRDAPADQQCVNMYDYTLRDEFPSCGMNWPPDLVNVKPFLNIPGVQSQLNLVHKKPWLECSGRVGRNFVAQRSKPAVHLLPSLLEDVPILLFNGNRDIICNYIGTEAFIKELEWNGQKGWDDDNVFDWNFDGNLAGYVRNSRNLTFVNVFNSSHMVPFDLPDTSRSLMDLVTGNFDIKDDKILTYKLGTRGQAKQSDKKPASTSSIPSEISATALASGSSSASAQASATANEADGDNNTSHKIERAIQLLVIIVLLWGIYALYSSYKSRPSSIIKSGPTGKKKNVQWADQLRRFQEDDQVRVQPHGIFAKALNKFKGNSDGAYAPVQGRYEDIEMSSASPIDDFVVVSDDEEEEPSRNEPSSNQK
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase KEX1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: NS49_CVBLU
Sequence: MKIKFVFDLLTPDDILHPSNHVNLIIRPI
What are the official names of this protein?
Truncated non-structural protein of 4.9 kDa, Truncated ns4.9, Truncated 4.9 kDa accessory protein.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses ns4.9 protein family.
Protein: GXLT2_XENLA
Sequence: MRFRWKFFGSLLCVTGLLLVLYRQLGNVPQPPPGPASAQGSPSLTATSGYFRALEDHVPRRDARQGGKKKTNWNNVRAPEQKPNPPMPEEWMHLAVVACGDRLEETVTMLKSAVLFSFKKIKFHIFAEDSLKSDFQMKLEIWPQQISRKIEYKIYPITFPGGNTQEWKKLFKPCAAQRLFLPMLLQDVDSLLYVDTDVLFLRPLDHVWAFLRRFNDTQLAAMAPEHEISKIGWYSRFARHPFYGTTGVNSGVMLMNLTRIRNQHFKNNMIPAGLTWEEMLHPLYQKYKNYITWGDQDLLNIIFYFNPEMLYVFPCHWNYRPDHCMYGSNCKAAEEEGVSILHGNRGVYHDEKQPAFKAFYEVIRDYTFDDNLFQSMYFPLQSKFLESVHTLCGRIPQVFLKQIEKTMKMMYERRVVVHIRSDV
What is the function of this protein?
Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
What are the official names of this protein?
Glucoside xylosyltransferase 2, Glycosyltransferase 8 domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: VPS29_MOUSE
Sequence: MLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS
What is the function of this protein?
Acts as component of the retromer cargo-selective complex (CSC).  The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.  The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway.  The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins.  The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5.  Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (By similarity).  Acts also as component of the retriever complex.  The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1).  In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.  The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes.  Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (By similarity).  Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates or a phosphorylated peptide derived from retromer cargo (in vitro) (PubMed:21629666, PubMed:15965486).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 29, Vesicle protein sorting 29.
What is the protein family that this protein belongs to?
Belongs to the VPS29 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Protein: CAPSD_HBVC2
Sequence: MDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQATLCWGELMNLATWVGSNLADPASRDLVVNYVNVNMGLKFRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSKSRESQC
What is the function of this protein?
Self assembles to form an icosahedral capsid.  Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins.  Entering capsids are transported along microtubules to the nucleus.  Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta.  Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153.  Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm.  Immature capsids get stuck in the basket.  Capsids encapsulate the pre-genomic RNA and the P protein.  Pre-genomic RNA is reverse-transcribed into DNA while the capsid is still in the cytoplasm.  The capsid can then either be directed to the nucleus, providing more genomes for transcription, or bud through the endoplasmic reticulum to provide new virions.
What are the official names of this protein?
Capsid protein, Core antigen, Core protein, HBcAg, p21.5.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus core antigen family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: CERU_HUMAN
Sequence: MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG
What is the function of this protein?
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein.  It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species.  It is involved in iron transport across the cell membrane.  Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1.  May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
What are the official names of this protein?
Ceruloplasmin, Ferroxidase.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments.
Protein: PTC2_AGACL
Sequence: MAFLKKSLLLVLFLALVPLSICEEEKREEEDEEKQEDDDQSENKRGLLSGILNSAGGLLGNLIGSLSNGES
What is the function of this protein?
Neutral peptide with no antimicrobial activity.  May act in synergy with cationic peptides by enhancing their activity.  Has a moderate hemolytic activity.
What are the official names of this protein?
Plasticin-C2, DRP-AC2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Plasticin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: SYE2_HELPJ
Sequence: MLRFAPSPTGDMHIGNLRAAIFNYIVAKQQNKPFLIRIEDTDKERNIEGKDREILEILKLMGISWDKLVYQSHNIDYHREMAEKLLKENKAFYCYASAEFLEREKEKAKNEKRPFRYLDEWATLEKDKNHAPVVRLKAPNHAVSFNDAIKKEVKFEPDELDSFVLLRQDKSPTYNFACACDDLLYEISLIIRGEDHVSNTPKQILIQQALGSNDPIVYAHLPIILDETSGKKMSKRDEASSVKWLLNQGFLPEAIANYLITIGNKVPKEVFSLDEAIEWFSLENLSSSPAHFNLKYLKHLNHEHLKLLDDDKLLELTLIKDKNLLGLLRLFIEECGTLLELKEKISLFLEPKDIVKTYENEDFKERCLTLFNALKSMDFQAYKDFESFKKEAMRLSQLKGKDFFKPLRILLTGNSHGVELPLIFPYIQSHHQEVLRLKA
What is the function of this protein?
Aminoacylates tRNA(Gln) with glutamate.  Does not aminoacylate tRNA(Glu) (By similarity).
What are the official names of this protein?
GlutamylGlutaminyl-tRNA synthetase, GluGlnRS, Glutamate--tRNA ligase 2, GluRS 2, Glutamyl-tRNA synthetase 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHS_SHEB9
Sequence: MTALSNMKCEACQADAPKVTDEELAELIRMIPDWGVQVRDGVMQLERVYKFKNFKLAMAFTNKLADLAEDEFHHPGIFTEWGKVTVTWWSHSIKGLHKNDFIMAAKTDQLLA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: SIX3_ISOMC
Sequence: KEGYGVGKDGCKISCVIGNEFCNKECKYSQKGTGGYCWTWGLACWCQGLPENAKVWESSTNTC
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity).  Induces paralysis in cricket A. domestica but does not induce death.
What are the official names of this protein?
Beta-insect depressant toxin Im-3.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: VIL1_ARATH
Sequence: MDSSSTKSKISHSRKTNKKSNKKHESNGKQQQQQDVDGGGGCLRSSWICKNASCRANVPKEDSFCKRCSCCVCHNFDENKDPSLWLVCEPEKSDDVEFCGLSCHIECAFREVKVGVIALGNLMKLDGCFCCYSCGKVSQILGCWKKQLVAAKEARRRDGLCYRIDLGYRLLNGTSRFSELHEIVRAAKSMLEDEVGPLDGPTARTDRGIVSRLPVAANVQELCTSAIKKAGELSANAGRDLVPAACRFHFEDIAPKQVTLRLIELPSAVEYDVKGYKLWYFKKGEMPEDDLFVDCSRTERRMVISDLEPCTEYTFRVVSYTEAGIFGHSNAMCFTKSVEILKPVDGKEKRTIDLVGNAQPSDREEKSSISSRFQIGQLGKYVQLAEAQEEGLLEAFYNVDTEKICEPPEEELPPRRPHGFDLNVVSVPDLNEEFTPPDSSGGEDNGVPLNSLAEADGGDHDDNCDDAVSNGRRKNNNDCLVISDGSGDDTGFDFLMTRKRKAISDSNDSENHECDSSSIDDTLEKCVKVIRWLEREGHIKTTFRVRFLTWFSMSSTAQEQSVVSTFVQTLEDDPGSLAGQLVDAFTDVVSTKRPNNGVMTSH
What is the function of this protein?
Involved in both the vernalization and photoperiod pathways by regulating expression of the related floral repressors FLOWERING LOCUS C (FLC) and FLOWERING LOCUS M (FLM).  Together with VIN3, required during vernalization for the modifications of FLC and FLM chromatin that are associated with an epigenetically silenced state (e. g.  chromatin modifications, histone deacetylation, and trimethylated H3 'Lys-4' H3K4me3 and 'Lys-27' H3K27me3) and with acquisition of competence to flower.  Promotes flowering in short days (SD=8 hours light/16 hours dark).  Associates dynamically at FLC locus; during vernalization, binds to specific sites, but when in warm conditions, distributed along the whole locus.
What are the official names of this protein?
VIN3-like protein 1, Protein VERNALIZATION 5.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Probably DNA-associated.
Protein: HIS6_XYLFM
Sequence: MLSRRIIPCLDVRDGRVVKGVKFRDHVDMGDIVELALRYRDHGADELVFYDIGASPQGRSVDYRWVERVARLIDIPFCVAGGIGEVETARAVLHAGADKISINSPALRQPALISALAEAFGVQCVVVGIDSIREADGQWRVRCNTGDPDKTQALPLRTLDWIVEAQRLGAGEIVLNCMDSDGVRCGYDIAQLSQARALCQVPLVASGGAGDMQHFADVFHKADVDGALAASVFHSGAISIPGLKQFLREQQIEVRDV
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNC_SHIBS
Sequence: MQTIIRVEKLAKTFNQHQALHAVDLNIHHSEMVALLGPSGSGKSTLLRHLSGLITGDKSAGSHIELLGRTVQREGRLARDIRKSRAHTGYIFQQFNLVNRLSVLENVLIGALGSTPFWRTCFSWFTREQKQRALQALTRVGMVHFAHQRVSTLSGGQQQRVAIARALMQQAKVILADEPIASLDPESARIVMDTLRDINQNDGITVVVTLHQVDYALRYCERIVALRQGHVFYDGSSQQFDNERFDHLYRSINRIEENAKAA
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DNAA_PROMA
Sequence: MLEASWEKVQSSLKQNLSKPSYETWIRPTEFSGFKNGELTLIAPNSFSSAWLKNNYSQTIQETAEEIFGEPVTVHVKVKANAESSDEHYSSAPITPPLEASPGSVDSSGSSLRLSKKTLPLLNLRYVFNRFVVGPNSRMAHAAAMAVAESPGREFNPLFICGGVGLGKTHLMQAIGHYRLEIDPGAKVSYVSTETFTNDLILAIRQDRMQAFRDRYRAADLILVDDIQFIEGKEYTQEEFFHTFNALHDAGSQIVLASDRPPSQIPRLQERLMSRFSMGLIADVQAPDLETRMAILQKKAEQERVGLPRDLIQFIAGRFTSNIRELEGALTRAIAFASITGLPMTVDSIAPMLDPNGQGVEVTPKQVLDKVAEVFKVTPDEMRSASRRRPVSQARQVGMYLMRQGTNLSLPRIGDTFGGKDHTTVMYAIEQVEKKLSSDPQIASQVQKIRDLLQIDSRRKR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1673_HELMI
Sequence: MLHVTFFGHANFLLDDGQTKVLIDPFFTGNPVCPIKADAVSADYILVSHGHGDHLGDAIDIAKGTGATIISSFELASYCQRKGVKAHGMAIGGKRDFPFGRVRLTAAVHGSGIIEGDNYLDVGNPCGFLVNMGGKSVYHAGDTGLTRDMELINMCFLKGGRLDLALLPIGDNFGMGPEDALYATKMLHPRMIVPMHYNTFPVIEQDVAAFKRVVTELTDSECHVLAPGDTLTLNGHGR
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Helmi_16730.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: RF1_ORITB
Sequence: MSFTVHLNKILQKYQDLEADLNGGKLDNKELALISKEYSNLKPIIEKLNRYLKAHENIKYLQQVIDTEQDLELKSIAEVELYDTLNYLPKLEEEVKISLLPKESDDHKNAIIEVRAGTGGDEAALFAASLFQMYNKYAERKKWKFELLSISDTEIGGCKEASALISGNGVFANLKFESGVHRVQRIPKTESNGRIHTSAATVVVLPEAEEVDVKIDAKDLKIDTYRASGAGGQHVNTTDSAVRITHIPTGVVVSQQDEKSQHKNKAKAMKILYARLYDLEKQKSKQEQAISRKVQVGTGDRSERIRTYNYPQGRVTDHRINLTLYKIEEIIQEGKLDEIINNLISENEAKKIADSNIQF
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.