PharMolix/UniProtQA huggingface dataset:
Protein: MN1_MOUSE
Sequence: MFGLDQFEPQINSRHAGQGEGNFNEAGLSMNAHFKAPAFHAGPPTGPVDPAISALGEPPILGLNMEPYGFHARSHSELHAGGLQAQPVHGFFGGQQPHHSHPGGHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAAGGLGSQPPFAESYEHMAESQGPEGFGPQRPGNLPDFHSSGTSGHAVPAPCLPLDQSPNRAASFHGLSASSGSDSHSLEPRRVTNQGAVDSLEYNYPSEPPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRASGMVGLSKMHSQPPQPPPQQQQPQHGVFFERFGGARKMPVGLEPAVGSRHPLMQPPQQAPPPPQQPPPQQQPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNGTLDNQLSPSAYPGLPGEFTPPVPDSFSSGPPLQHPGPDHQSLQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHGGSVGGLAQTNFEREGGSAGAGRLSGFEQQAPHLAQESAWFPGPHPPGDLLPRRMGGAGLPTDCGPHDPALAPPPAPGGSGVLFRGSLQEPLRMPGEGHVPALASPGLQFGGSLAGLGQLQSPGAGVGLPNAPSERRPPPPDFPAPALGGQPGFPFGSGSRQATPHSAPGVNSPPSAGSGSSGAGGGAYPPQPDFQPSQRNSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNEPDSAVAAGNPGSDYFPGGTTPGAPGPGGPSGTSGGGSKASGPPNPPIQGDSTSLSPNYTLESTSGNDGKPVPGGSGRGRGRRKRDSGHVSPGTFFDKYSTAPDSGGAPGVSPGQQQAPGSAAGGSSVNEARGPTPHEKALTSPSWGKGAELLLGDQPDLMASLDSTAKSDGSSPHVGEFASDEVSTSYANEDEVSSSSDNTTALAKASRSPLVTSSPKLPPRGVGAGEHTPKASALGLGILSTSTSTPDSYGGGVGTGHPGTPGLEQVRTPTSSSGAQPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGSKKAECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSTTWYMPPDKALVDGGDEDKTLAPWEKAKSQNPNNKEAHDHPTNKASATQPGSHLQCLTVHCTDGDPKARTSVPTWRSLHSDISNRFGTFVAALT
What is the function of this protein?
Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate (PubMed:18948418).  Required during later stages of palate development for normal growth and medial fusion of the palatal shelves (PubMed:18948418).  Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL (PubMed:19386590).  Necessary for normal development of the membranous bones of the skull (PubMed:15870292).  May play a role in tumor suppression (By similarity).
What are the official names of this protein?
Transcriptional activator MN1.
What are the subcellular locations of this protein?
Nucleus.
Protein: MICA_CLAMM
Sequence: MNDILETETPVMVSPRWDMLLDAGEDTSPSVQTQIDAEFRRVVSPYMSSSGWLCTLTIECGTIICACR
What is the function of this protein?
Lanthionine-containing peptide antibiotic (lantibiotic) active against S. michiganensis subspecies sepedonicus strain 2136 (MIC=30 pmol/ml).  The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
What are the official names of this protein?
Lantibiotic michiganin-A.
What is the protein family that this protein belongs to?
Belongs to the type B lantibiotic family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRH_PARZE
Sequence: MTSETPKQYGRVMLKISGEALMGDQGFGLNPPTVARIANEVDSVAKMGVEVCMVIGGGNIFRGLQGSAQGMERTTADYMGMLATVMNALAMQSALEALGHHCRVISAIRMDEVCEPYIRRRAIRHLEKKRIVIFAAGTGNPYFTTDTAATLRASEMNCEAIFKGTKVDGVYDKDPVKHADAKRYGDVSYDEVLQKHLGVMDASAIALARDNKLPIIVFSLDAPGGFRSILAGSGTYTRVHV
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPE_PECAS
Sequence: MSCPVIELAQQLIKRPSLSPNDEGCQALMIERLTAIGFTVEAMDFGDTQNFWAWRGTGKTLAFAGHTDVVPSGDESHWQHPPFEPIIRDGMLYGRGAADMKGSLAAMVIAAERFVAAHPNHQGRLAFLITSDEEASAVNGTVKVVDALMARNERLDYCLVGEPSSTHVVGDVVKNGRRGSITANLRIHGMQGHVAYPHLADNPVHRAAPALNELIATEWDRGNDFFPPTTMQIANIQAGTGSNNVIPGELFVQFNFRFSTELTDVLIQQRVAELLDRHQLNYTIDWKLSGQPFLTARGELVDAVVNAVKHYNEVTPELLTNGGTSDGRFIARMGAQVVELGPINATIHKVDECVSAADLQLLSRMYQRIMEQLIA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: KLRI2_RAT
Sequence: MPRKKQNERGTNKQEIINIETKSSTFQEKQRQSKTDQISTVWRKEQKKQELKVHTELHPQHRTGFNEDKGTDPWLTTWRIITVILGTSCIILVTKVGFLIPNLFSRGEKRSRELSLLDSLCLKNNDSFCDLCSHDWIAFGNNFYLFFRGTKTWAESKSACEELNSYLLDIDSRAELENLLLFEINGWILFKTDAINRSLRKNYIKIHQTLFNDSEKKNHSCHYLSGNQFSAGDCSSKKAYTCEFNLQ
What is the function of this protein?
Lectin-like receptor for natural killer (NK) cells.  Heterodimer formation with KLRE1 mediates NK cell cytolytic activity.
What are the official names of this protein?
Killer cell lectin-like receptor subfamily I member 2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: FLGI_ECO27
Sequence: MIKFLSALILLLVITAAQAERIRDLTSVQGVRQNSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTASLPPFGRQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAVIERELPSQFGVGNTLNLQLNDEDFSMAQQIADTINRVRGYGSATALDARTIQVRVPSGNSSQVRFLADIQNMQVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQANVSQPDTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSASLNNVVRALNALGATPMDLMSILQSMQSAGCLRAKLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: FABV_ALIF1
Sequence: MIIKPRIRGFICTTTHPVGCEQNVKEQIALTKAQGPIANAPKRVLVVGSSSGYGLSSRITAAFGGGASTIGVFFEKAGTEKKPGTAGWYNSAAFDKFAKEEGLYSKSLNGDAFSNEAKQKTIDLIKEDLGQIDMVVYSLASPVRKMPETGEVIRSSLKPIGETYTATAVDTNKDAIIEASVEPATEQEIKDTVTVMGGEDWELWINALSEAGVLADGCKTVAYSYIGTELTWPIYWDGALGQAKMDLDRAATALNEKLSATGGTANVAVLKSVVTQASSAIPVMPLYIAMVFKKMREEGVHEGCQEQILRMFSQRLYKADGSAAEVDEKNRLRLDDWELREDIQQHCRDLWPQVTTENLKDLTDYVEYKEEFLKLFGFGVDGVDYDADVNPEVNFDVADI
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: RS9_BIFAA
Sequence: MAENTNDSAVLETEEELTSYTTETNAGAGTGTSTIAPGYGTGRRKEAVARVRLVPGTGKWTINGRTLEEYFPAKLLQREVNSPIVLLKLEGKFDAIVLVDGGGTTGQAGAIRLGVARALNAIDRDANRAALKKAGFLTRDARVVERKKAGLHKARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: VBA5_YEAST
Sequence: MEETKYSSQQEIEGACGSDASLNARGSNDSPMGLSLYLCLASLTLVLFITALDILIVGTIIDVVAEQFGNYSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIFGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIMFLLTYKAENKGILQQIKDAIGTISSFTFSKFRHQVNFKRLMNGIIFKFDFFGFALCSAGLVLFLLGLTFGGNKYSWNSGQVITYLVLGVLLFIFSLVYDFFLFDKFNPEPDNISYRPLLLRRLVAKPAIIIVNMVTFLLCTGYNGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLVKPLLIFGGVLGVIGAGLMTLMTNTSTKSTQIGVLLLPGFSLGFALQASLMSAQLQITKDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTVFSASFHNKVSRAHLEPYEGKTVDDMILYRLQNYDGSHSTIGNILSDSIKNVFWMDLGFYALGFLFCSFSSNKKLIIPKKDDTPEDNLEDK
What is the function of this protein?
Transporter required for vacuolar uptake of basic amino acids.
What are the official names of this protein?
Vacuolar basic amino acid transporter 5.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: LIPG_RAT
Sequence: MWLLLITSVISTFGGAHGLFGKLGPGNPEANMNISQMITYWGYPCQEYEVVTEDGYILGVYRIPHGKNNSENIGKRPVVYLQHGLIASATNWIANLPNNSLAFMLADAGYDVWLGNSRGNTWSRKNVYYSPDSVEFWAFSFDEMAKYDLPATINFIVQKTGQEKIHYVGHSQGTTIGFIAFSTNPTLAKKIKTFYALAPVATVKYTQSPLKKISFIPTFLFKLMFGKKMFLPHTYFDDFLGTEVCSREVLDLLCSNTLFIFCGFDKKNLNVSRFDVYLGHNPAGTSVQDFLHWAQLVRSGKFQAFNWGSPSQNMLHYNQKTPPEYDVSAMTVPVAVWNGGNDILADPQDVAMLLPKLSNLLFHKEILAYNHLDFIWAMDAPQEVYNEMISMMAED
What is the function of this protein?
Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:3839077).  Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (By similarity).
What are the official names of this protein?
Gastric triacylglycerol lipase, GL, Gastric lipase, Lingual lipase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: PAU11_YEAST
Sequence: MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSSRLKPAISSALSKDGIYTIAN
What are the official names of this protein?
Seripauperin-11.
What is the protein family that this protein belongs to?
Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
Protein: RNC_STAA3
Sequence: MSKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLKQIK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IKBL1_RAT
Sequence: MSNPSPQAPEEEASTSVCRPQSSMASVSRRHRRERRFRRYLSAGRLVRAQALLQRHPGLDVDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPNAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEDEEVSKEREWRQKLQGELEDEWQEVIGRFEDDASRETQEPESFSAWSERLAREHAQKQRRQQLEAEGSRRPPRAEGSSHSWRQQEEEQRLFRERARVKEKELCESRARRAQEAQGDRGPAPPRARPRAEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALKRYLRVQQVRWHPDRFLQRFRNQIETWELGRVMGAVTALSQALNRHAEALK
What is the function of this protein?
Involved in the regulation of innate immune response.  Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways.  Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (By similarity).
What are the official names of this protein?
NF-kappa-B inhibitor-like protein 1, Inhibitor of kappa B-like protein, I-kappa-B-like protein, IkappaBL, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1.
What are the subcellular locations of this protein?
Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus (By similarity).
Protein: UPPS_HALSA
Sequence: MRTRLWDAASAVYERLLTREIDGAPAHVAVIQDGNRRYAREHGDDPTDGYQSGARTTERVLEWCSDLGVEELTLYAFSTENFERPPDQQQHLFDLLESKLREFADADRVHADRVRIRAIGDTGRLPQRVRDAITYAESRTAGYDGFTLNVALAYGGRDELLTAARGVADAVAAGDLDPADIDAQAIESRLHTSPVRDVDLIIRTGGDERTSNFLPWHANGSEAAVFFCTPYWPEFSKVDLLRAIRTYESRAASWRQTRAKRALALVRALGSEVGEARRVLDRFKGALPDPPEDVEAETQSAD
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP).  It is probably the precursor of glycosyl carrier lipids.
What are the official names of this protein?
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific), Undecaprenyl diphosphate synthase, UDS, Undecaprenyl pyrophosphate synthase, UPP synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: RF3_ECODH
Sequence: MTLSPYLQEVAKRRTFAIISHPDAGKTTITEKVLLFGQAIQTAGTVKGRGSNQHAKSDWMEMEKQRGISITTSVMQFPYHDCLVNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDAAKGVEDRTRKLMEVTRLRDTPILTFMNKLDRDIRDPMELLDEVENELKIGCAPITWPIGCGKLFKGVYHLYKDETYLYQSGKGHTIQEVRIVKGLNNPDLDAAVGEDLAQQLRDELELVKGASNEFDKELFLAGEITPVFFGTALGNFGVDHMLDGLVEWAPAPMPRQTDTRTVEASEDKFTGFVFKIQANMDPKHRDRVAFMRVVSGKYEKGMKLRQVRTAKDVVISDALTFMAGDRSHVEEAYPGDILGLHNHGTIQIGDTFTQGEMMKFTGIPNFAPELFRRIRLKDPLKQKQLLKGLVQLSEEGAVQVFRPISNNDLIVGAVGVLQFDVVVARLKSEYNVEAVYESVNVATARWVECADAKKFEEFKRKNESQLALDGGDNLAYIATSMVNLRLAQERYPDVQFHQTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATGA1_DANRE
Sequence: MNCRSEVLEVSVEGRQVDEAMLGLLHTILLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFTFVRVSSDELDRVIRKAVAEFKDALGNSGSDGMGQISLEFYQKKKSRWPFSDECIPWEVWSIKVNVVNLANEQERQICREKVGEKLGEKVINIVEVINRHEYLPKMPTQSEVDNVFDTSLKDVQPYLYKITYQITDSLGTSVSTTMRRLIKDTLAL
What is the function of this protein?
Autophagy factor required for autophagosome formation.
What are the official names of this protein?
Autophagy-related protein 101.
What is the protein family that this protein belongs to?
Belongs to the ATG101 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure. Note=Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.
Protein: DEOD_SALEP
Sequence: MATPHINAEMGDFADVVLMPGDPLRAKHIAETFLEDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVRMDVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGVDARVGNLFSADLFYSPDGEMFDVMEKYGVLGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDQE
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: RK16_NUPAD
Sequence: MLSPKRTRFRKQHRGRMKGVSYRGNHICFGRYALQALEPAWITSRQIEAGRRAMARYARRGGKIWVRIFPDKPVTLRPAETRMGSGKGSPEYWVSVVKPDRILYEMGGVSETVARAAMELAARKMPIRTKFVIEE
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TM2NV_SOLLC
Sequence: MAEILLTSVINKSVEIAGNLLIQEGKRLYWLKEDIDWLQREMRHIRSYVDNAKAKEAGGDSRVKNLLKDIQELAGDVEDLLDDFLPKIQQSNKFNYCLKRSSFADEFAMEIEKIKRRVVDIDRIRKTYNIIDTDNNNDDCVLLDRRRLFLHADETEIIGLDDDFNMLQAKLLNQDLHYGVVSIVGMPGLGKTTLAKKLYRLIRDQFECSGLVYVSQQPRASEILLDIAKQIGLTEQKMKENLEDNLRSLLKIKRYVFLLDDVWDVEIWDDLKLVLPECDSKVGSRIIITSRNSNVGRYIGGESSLHALQPLESEKSFELFTKKIFNFDDNNSWANASPDLVNIGRNIVGRCGGIPLAIVVTAGMLRARERTEHAWNRVLESMGHKVQDGCAKVLALSYNDLPIASRPCFLYFGLYPEDHEIRAFDLINMWIAEKFIVVNSGNRREAEDLAEDVLNDLVSRNLIQLAKRTYNGRISSCRIHDLLHSLCVDLAKESNFFHTAHDAFGDPGNVARLRRITFYSDNVMIEFFRSNPKLEKLRVLFCFAKDPSIFSHMAYFDFKLLHTLVVVMSQSFQAYVTIPSKFGNMTCLRYLRLEGNICGKLPNSIVKLTRLETIDIDRRSLIQPPSGVWESKHLRHLCYRDYGQACNSCFSISSFYPNIYSLHPNNLQTLMWIPDKFFEPRLLHRLINLRKLGILGVSNSTVKMLSIFSPVLKALEVLKLSFSSDPSEQIKLSSYPHIAKLHLNVNRTMALNSQSFPPNLIKLTLANFTVDRYILAVLKTFPKLRKLKMFICKYNEEKMALSGEANGYSFPQLEVLHIHSPNGLSEVTCTDDVSMPKLKKLLLTGFHCGISLSERLKKLSK
What is the function of this protein?
Inhibitor of viral mouvements which confers resistance to some tobamoviruses including tomato mosaic virus (ToMV) (e. g.  isolate L and W3) and tobacco mosaic virus (TMV), but not to resistance-breaking isolates (e. g.  Ltbl) ToMV and tomato brown rugose fruit virus (ToBRFV) (PubMed:2535549, PubMed:29582165).  Elicits a hypersensitive reaction in response to avirulent (Avr) movement proteins from resistance inducing tobamoviruses (e. g.  ToMV and TMV) strains, thus leading to programmed cell death (By similarity).
What are the official names of this protein?
ToMV resistant protein Tm-2 netted virescent, ToMV resistant protein Tm-2nv.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GYRA_STRP1
Sequence: MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPARFPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVLRSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKLTSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETDVIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPRRTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELISTSTHDTLLFFTNFGRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALKLKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIQDNQEVLVITENGFGKRTSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKIVTFTLVQPEDSSIAEINTDRENSISKNKDN
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_BURO1
Sequence: MANVVENLGKLERRVTISLPKDTVQKEIDARIQKLAKTVRMPGFRPGKVPLKMVAQQYAGQVEAEVLSDKIGQEFFTVSRAENLRVAGQPSFEPKQEQAEDAYAFDATFEVYPEVKIGDLATAEVERSTTSIGDAEIDRTLDILRKQRVHYHARGEAGEHGDGGADTAAKNGDRVTVDFVGKIEDVAFQGGTAEDFPFVLGEGRMLPEFETAALGLKVGEQRTFDLKFPDDYHGKDVAGKTAQFTVTMKKIEWPHLPEIDAEFAKSLGIEDGDLTKMRAEIKENLEREAKRRTQSIVKNQVMDALLKISELDVPKALIEQDQQRLVEMARQDLAQRGVPNAKDAPIPAEMFAEQAERRVKLGLVLAELVKANGLEAKPEQIRAEVDEFAKSYEDPKEVVRWYYSNQQRLAEMEAFVVESNVVDFVLGKAKVTDKEVSFEALASASAQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
Protein: MSCL_LISW6
Sequence: MKKMLVEFRDFALKGNVLDLAVAVVIGAAFGKIVSSLVDNIIMPVVGVLLGGLDFTKLSVTVGKSVIQYGAFIQSIVDFIIIAFAIFIFVKILTSFMKKKEQPVEETPVPPTEEYLKEIRDLLKEQQKEI
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PLSX_ROSDO
Sequence: MTAQTGQTQSQDARIIISVDAMGGDEGPAAVIAGCDVSARKNPDVFFILHGPEAEITALVNRRKSLQGRCEVRDATGVVTMDDKPSQVVRNSKGTSMWSAIEAVRDGSASVAVSCGNTGALMALSMIRLRKLPGVNRPAIAVLYPSSNQQGFNVLLDVGADIKADADDLLRYALMGMSYARNGLDLPRPRVGLLNVGTEEHKGRTELKEAFDLIKEQQEPAGFDFVGFVEGGDISGDLCDVIVTDGFTGNVAIKTGEGTANLVGNRLREAFRYTPLSRLASLLAYPSLRRLKKKIDPRRVNGGVFLGLNGTVVKSHGAADATGVSSAIKLAAQLAHIQFTDKLAARVAGLPAEEKTQ
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: TPPC4_HUMAN
Sequence: MAIFSVYVVNKAGGLIYQLDSYAPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGMDVNGRYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS
What is the function of this protein?
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable).  Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024).  May play a role in dendrite postsynaptic membrane trafficking (By similarity).
What are the official names of this protein?
Trafficking protein particle complex subunit 4, Hematopoietic stem/progenitor cell protein 172, Synbindin, TRS23 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.
Protein: UVRB_PROM3
Sequence: MPKYHLKAPYSPKGDQPTAIARLVEGVNQGQRYQTLLGATGTGKTFTIANLIAQTGRPALVLAHNKTLAAQLCNEFREFFPDNSVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERNDVIVVASISCIYGLGIPSEYLKAAVKFKVGETLNLRSSLRELVDNQYSRNDFDITRGRFRVRGDVLEIGPAYEDRLVRIELFGDEVEAIRYLDPTTGEILQSLEAINIYPAKHFVTPKERLNVAVQAIRDELRERLQVLNEQGKLLEAQRLEQRTAYDLEMLREVGYCNGVENYARHLAGRSAGTPPECLIDYFPDDWLLVVDESHVTCSQLKAMYNGDQARKKVLIEHGFRLPSAADNRPLKSEEFWRKARQTVFVSATPGDWELTQSDGQLAEQVIRPTGVLDPLVEVRPTQGQVDDLLAEIRIRAKKQERVLITTLTKRMAEDLTDYLAENDVRVRYLHSEIHSIERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAERSLIQTIGRAARHVDGMALLYADNLTDSMARAISETERRREIQKAYNELNGIVPRPAGKRASNSILSFLELSRRLQTDGKDADLVQITGRAVDALDSDQDSGLALDALPELIDQLETKMKEAAKNLNFEEAASLRDRIKKFRQKLIRNT
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.