PharMolix/UniProtQA huggingface dataset:
Protein: HEM6_GLOVI
Sequence: MQSLQDNITSRLEAVDGEGRFVEDLWEREEGGGGRSRILTEGRVFERAGIGFSEVHGSHLPPSILQQRPEAEGHPFYVTGTSMVLHPRNPYVPTVHLNYRYFEAGPVWWFGGGADLTPYYGFVEDAAHFHATLKAACDAHDPEYYPRFKKWCDEYFYLKHRQEPRGVGGIFFDYVQGDWEKIFAFAQSCGNAFLPAYLPIVERRHTLPYAERERNFQLYRRGRYVEFNLVWDRGTIFGLQTNGRIESILMSMPPLVRWEYNYRPEPGTAEAELYEVFLVPQDWASQAKR
What is the function of this protein?
Involved in the heme and chlorophyll biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_LUMRU
Sequence: MSFRRFVEIGRVARAVYGPDQGKLVAIVDVIDQNRALVDGPCTHVARKSMNFKELELTNLKAKFPHSAKTGVVKKAWEKDEISKKWEESHLAKKIAAKEKRKTLTDFERFKLMKAKQARNRLIKIEFGKLRKALKKTPAKPTRKPNKKLHKV
What are the official names of this protein?
60S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL14 family.
Protein: FOXD2_XENLA
Sequence: MTLGTEMSDNSLLSEDTDIDVVGDMGAKDGKYSDYHSDNDSDDNVARTPRGDPASPDLSSGSESNQRAEKSPKNALVKPPYSYIALITMSILQSPKKRLTLSEICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQQSNEILRDPSSFMPAAFGYGPYGYNYGLQLHNYQQHPGATFSFQPSHCPLPPPASVFSSPTLSPFLGNELSRKSLYSQLSPTLPILHTLKPDAQSRPSFSIDNIIGGSGSTPSPTSPYTAQPGTHPPVIAMLSPSLAPMHNHLNLAHENLLPPGQNFSSKITNLNSCHF
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Forkhead box protein D2, FoxD2, xFoxD2, Fork head domain-related protein 9, xFD-9, Forkhead protein 3, FKH-3, xFKH3.
What are the subcellular locations of this protein?
Nucleus.
Protein: KPRS_SULTO
Sequence: MIIIGGTATNGIDENLSKIISVPLLKVEHKVFPDGESYIRIPQHITNQEILVVQSLYPPQDKHFVELLLILETLADMKNNKITAIVPYLAYSRQDRRFKEGEALSIKTILNAIARAGADVLIVIEPHKEEELSYFGKEVKIADPMPELAKEVSKKVEKPFVLAPDRGALERAKRLAEQLNAEYSYIEKERDRDTGEVRIKNLPELRLSGKDVIIVDDIISTGGTMIQATRAAYEHGARKVISVAVHSLFLDNAYEKLINSGVKEIVTTNTIPQDPSKVTVVDVSPAIARKI
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLYX_RHILO
Sequence: MPADRLTTLEIRAAEQERTIEELSGQIAEQWTVIERMQRKLDALTDRFLALEEQAAPDVPVTKPPHW
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: BIOP_SALTI
Sequence: MALLIITTILWAFSFSLFGEYLAGHVDSYFAVLIRVGLAALVFLPFLRTRGHNLKTISLYMLVGAMQLGIMYMLSFHAYLYLTVSELLLFTVLTPLYITLIYDVMSQRRLRWGYAFSALLAVIGAGIIRYDRVTDHFWVGLLLVQLSNISFAIGMVGYKRLMETRPMPQHNAFAWFYLGAFLVAAVAWSLLGNAQKLPETTLQWSILVFLGVVASGIGYFMWNYGATQVDAGTLGIMNNMHVPAGLLVNLAIWHQQPHWPSFITGAAVILASLWVHRKWVAPRSAQTADDRRRDPASSE
What is the function of this protein?
Uptake of biotin.
What are the official names of this protein?
Biotin transporter.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRI13_MOUSE
Sequence: MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGLLEGNVRNSLWRPSPFKCPTCRKETSATGVNSLQVNYSLKGIVEKYNKIKISPKMPVCKGHLGQPLNIFCVTDMQLICGICATRGEHTKHVFSSIEDAYAREKNAFESLFQSFETWRRGDALSRLDTLETNKRKALQLLTKDSDKVKEFFEKLQHTLDQKKNEILSDFETMKLAVMQTYDPEINKINTILQEQRMAFNIAEAFKDVSEPIIFLQQMQEFREKIKVIKETPLPHSNLPTSPLMKNFDTSQWGDIKLVDVDKLSLPQDTGVFTSKIPWYPYLLLMMVVLLGLLIFFGPTVFLEWSPLDELATWKDYLSSFNSYLTKSADFIEQSVFYWEQMTDGFFIFGERVKNVSLVALNNVAEFICKYKLL
What is the function of this protein?
Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD).  This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.  Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation.  Regulates ER stress-induced autophagy, and may act as a tumor suppressor.  Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway.  Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation.  Participates as well in T-cell receptor-mediated NF-kappa-B activation.  In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B.
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM13, Putative tumor suppressor RFP2, RING-type E3 ubiquitin transferase TRIM13, Ret finger protein 2, Tripartite motif-containing protein 13.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum.
Protein: F263_BOVIN
Sequence: MPLELTQSRVQKIWIPVDHRPSLPRTCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNLGEYRRDGVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLTKEGGQIAVFDATNTTRERRHMILHFPKENDFKVFFIESVCDDPTVVASNIMEVKISSPDYKDCNSRENAMDDFMKRINCYEASYQPLDPDNDDRDLSLIKVIDVGQRFLVNRVQDHIQRRIVYYLMNIHWQPRTIYLCRHGESKHNLQGKIGGDSGLSSRGRKFANALSKFVEEQNLKDLKVWTSQLKSTIQTAEALQLPYEQWKALNEIDAGVCEEMTYEEIKDTYPEEYALAEADKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVCVCLLAYFLDKSAEEMPYLKCPLHAVLKLTPIAYGCRVESIYLNVESVSTHRERSEDAKKGPNPLMRSNSH
What is the function of this protein?
Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.
What are the official names of this protein?
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 6PF-2-K/Fru-2,6-P2ase 3, PFK/FBPase 3, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the phosphoglycerate mutase family.
Protein: SCPA_STRP3
Sequence: MDIKLKDFEGPLDLLLHLVSQYKVDIYEVPIVEVIEQYLNYIETLQVMKLEVAGDYMLMASQLMLIKSRRLLPKVVEHIEEEDLEQDLLEKIEEYSRFKAVSQALAKQHDQRAKWYSKPKQELIFEDAILQEDKTVMDLFLAFSNIMAAKRAVLKNNHTVIERDDYKIEDMMASIKQRLEKENVISLSAIFEECQTLNEVISIFLASLELIKLHVVFVEQLSNFGAIILRKEKK
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: YACG_SHIB3
Sequence: MSETITVNCPTCGKTVVWGEISPFRPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESDDWSEEPKQ
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: RS7_BURM9
Sequence: MPRRREVPKREVLPDPKYGNVDVAKFMNMLMLSGKKSVAERIVYGAFEQIQTKGGKDPLEVFTVALNNVKPVVEVKSRRVGGANYQVPVEVRPSRRMALAMRWLREAAKKRSEKSMALRLAGELSEAAEGRGGAMKKRDEVHRMAEANRAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: Y039_RICCN
Sequence: MTNNQFSEDTKKIADQIKDALMGISDDLVLESKEVEEIFEELSQNEEFEYEMERMLSILNEQTMDLTQLQSRIILLIRKYLGKTKNLKLKMLKMDEKLINKNVAEVSNYLMHQHSKIVRDANKNLTNPKDKLQGLTKQARIDLKRLLKSFAVYQIYMFMNPKRIAGETKLMNFAYNMIKGGMKLAKKYEGGKEQEIKSYSPRLIKKLKKAHVGFKKSGGISI
What are the official names of this protein?
Uncharacterized protein RC0039.
Protein: ATPL_PSEU2
Sequence: METVVGLTAIAVALLIGLGALGTAIGFGLLGGKFLEGAARQPEMVPMLQVKMFIVAGLLDAVTMIGVGIALFFTFANPFVGQLAG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FTSL_BURPS
Sequence: MSRLNIFLLIIVMGCALSVVNSTNQQRQIFIQLQRAQSQEHQLQQDYAQLQYQQSALSKTSRIEQLATSSLKMQPITTGRTQYLTLSPGAAKAVDVPLPASAAPTGGAR
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsL.
What is the protein family that this protein belongs to?
Belongs to the FtsL family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum where it forms a ring structure.
Protein: HTRA1_MOUSE
Sequence: MQSLRTTLLSLLLLLLAAPSLALPSGTGRSAPAATVCPEHCDPTRCAPPPTDCEGGRVRDACGCCEVCGALEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDAKTYTNLCQLRAASRRSEKLRQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAVTKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVTANDVSDVIKKENTLNMVVRRGNEDIVITVIPEEIDP
What is the function of this protein?
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin.  HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production.  May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin.  Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space.  Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins.  Inhibits signaling mediated by TGF-beta family members.  This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves (PubMed:18551132) or not (PubMed:14973287).  By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development.  Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
What are the official names of this protein?
Serine protease HTRA1, High-temperature requirement A serine peptidase 1, Serine protease 11.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell membrane. Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane.
Protein: DES6_PHYPA
Sequence: MVFAGGGLQQGSLEENIDVEHIASMSLFSDFFSYVSSTVGSWSVHSIQPLKRLTSKKRVSESAAVQCISAEVQRNSSTQGTAEALAESVVKPTRRRSSQWKKSTHPLSEVAVHNKPSDCWIVVKNKVYDVSNFADEHPGGSVISTYFGRDGTDVFSSFHAASTWKILQDFYIGDVERVEPTPELLKDFREMRALFLREQLFKSSKLYYVMKLLTNVAIFAASIAIICWSKTISAVLASACMMALCFQQCGWLSHDFLHNQVFETRWLNEVVGYVIGNAVLGFSTGWWKEKHNLHHAAPNECDQTYQPIDEDIDTLPLIAWSKDILATVENKTFLRILQYQHLFFMGLLFFARGSWLFWSWRYTSTAVLSPVDRLLEKGTVLFHYFWFVGTACYLLPGWKPLVWMAVTELMSGMLLGFVFVLSHNGMEVYNSSKEFVSAQIVSTRDIKGNIFNDWFTGGLNRQIEHHLFPTMPRHNLNKIAPRVEVFCKKHGLVYEDVSIATGTCKVLKALKEVAEAAAEQHATTS
What is the function of this protein?
Fatty acid desaturase able to introduce a delta(6)-double bond into delta(9)-unsaturated fatty-acid substrates.  Can use both linoleic acid (18:2(9Z,12Z)) and alpha-linolenic acid (18:3(9Z,12Z,15Z)) as substrates.  Required for the biosynthesis of arachidonic acid (20:4(5z,8Z,11Z,14Z)).
What are the official names of this protein?
Acyl-lipid (9-3)-desaturase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MUKF_SALTY
Sequence: MSEFSQTVPELVAWARKNDFSISLPVDRLSFLLAVATLNGERLDGEMSEGELVDAFRHVSDAFEQTSETIGVRANNAINDMVRQRLLNRFTSEQAEGNAIYRLTPLGIGITDYYIRQREFSTLRLSMQLSIVAGELKRAADAAAEGGDEFHWHRNVYAPLKYSVAEIFDSIDLTQRIMDEQQQQVKDDIAQLLNKDWRAAISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDKNRVFAQRLRQSVQTYFDDPWALTYANADRLLDMRDEEMALRDDEVTGELPPDLEYEEFNEIREQLAAIIEEQLAIYKTRQTPLDLGLVVREYLAQYPRARHFDVARIVIDQAVRLGVAQADFTGLPAKWQPINDYGAKVQAHVIDKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: GLMS_BORPA
Sequence: MCGIVGAVAQRDITPILIEGLKRLEYRGYDSCGVALYMDGHLRRTRSTKRVAELSEQVAEDKLGGFTGIAHTRWATHGIPATYNAHPHFSAQGKDEPRIALVHNGIIENHEELRQELQGVGYVFESQTDTEVIAHLVNHLYAGDLFEAVQQAVRRLQGAYAIAVFCRDEPHRVVGARQGSPLVVGLGQNENFLASDALALAGTTDQIIYLEDGDVVDLQLARVWIVDQAGKQVERKAHTVQVHTGAAELGPYRHFMQKEIFEQPRAVGDTLQDIESITPELFGDGAYKVFKEIDSLLILACGTSYYAGLTAKYWIESIARIPVAVEIASEYRYRDSVPNPNALVVTISQSGETADTLAALKHARSLGMQHTLTVCNVATSAMVRECELAYITRAGVEIGVASTKAFTTQLTALFLLTLALAQTRGRLTEEQEAEHLKALRHLPAAIGAVLALEPQIMAWADRFASKENALFLGRGMHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEHMPVVTIAPKDALLEKLKSNMQEVRARGGELYVFADADSKIANAEGMHVIRMPEYYGALSPIVHTIPLQLLSYHTACVRGTDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LBM_DROME
Sequence: MGCATTSVKIASIVLNAVLGFLAAGAIGWIAYNADTETEEFVIAAYIACSLILVFALLGIFAAIRESVVLTATSAVFLLILAILQIVSTCLFLHEFDVKSGRDMVEVAWQANNMDSLQQKHECCGQSSAQDYIHLSLLIPPSCYADLQQTPDHLYLDGCIEKVQSFYESDKLRFIIVSWVLVAFELICFALAVFLAISFKNKQRRMEF
What is the function of this protein?
Facilitates synapse formation.
What are the official names of this protein?
Protein late bloomer.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Synapse.
Protein: PYRC_YEAST
Sequence: MVQEIDLGLTCDMHVHVREGAMCELVTPKIRDGGVSIAYIMPNLQPPITTLDRVIEYKKTLQKLAPKTTFLMSFYLSKDLTPDLIHEAAQQHAIRGVKCYPAGVTTNSAAGVDPNDFSAFYPIFKAMQEENLVLNLHGEKPSVHDGDKEPIHVLNAEEAFLPALKKLHNDFPNLKIILEHCTSESAIKTIEDINKNVKKATDVKVAATLTAHHLFLTIDDWAGNPVNFCKPVAKLPNDKKALVKAAVSGKPYFFFGSDSAPHPVQNKANYEGVCAGVYSQSFAIPYIAQVFEEQNALENLKGFVSDFGISFYEVKDSEVASSDKAILFKKEQVIPQVISDGKDISIIPFKAGDKLSWSVRWEPR
What is the function of this protein?
Catalyzes the conversion of ureidosuccinic acid (USA) to dihydroorotate, the third step of the de novo pyrimidine biosynthetic pathway.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: G3P2_STRAE
Sequence: MTVRIGINGFGRIGRNVFRAAAARSSELEIVAVNDLGDVPTMAHLLAYDSILGRFPEEVTAEPGAIRVGDRTIKVLAERDPGALPWGDLGVDIVIESTGIFTDAAKARSHVDGGAKKVIIAAPASGEDFTVVLGVNDGDYDPERHTIISNASCTTNCLGVLAKVLHDAVGIDSGMMTTVHAYTQDQNLQDAPHKDLRRARAAALNIVPTSSGAAKAIGLVLPELAGRLDAFALRVPVPTGSVTDLTVTTRRGTSVEEVKEAYAAAASGPYKGLLSYVDAPLVSTDIVGDPASCVFDAGLTRVSGPQVKVVGWYDNEWGYSNRLIDLATLIGSSL
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 2, GAPDH 2, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase, PL-sensitive glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FETP_COLP3
Sequence: MSRTVFCQNLNKEAEGLGFQLYPGEIGKRIFDNISKEAWTIWQKKQTMLINEKKMNMMNVDDRAFLEAAMVAYLFEGKEPEIEGYVPPSK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: GPT11_XENTR
Sequence: MEEEEEDYMSDAFINSLQDVRPGMSMPRRVKECYEKEEKHKEANIKNRQQKLKDVEKEKRDTKLNEALGNENKGFALLQKMGYKKGQALGKKGDGIVEPIPLNIKTGRSGIGHEEMKKRKAEENLESYRRKIQMRKHDEEQAADDFRMRMKSKREEIRLKADLSKSQRACMLLDGQKSISTPREAWYWPKMNEQEADEEADEETEEDEDLVEEELSTLEKLQILTSYLRGRHLFCIWCGTTYQDDEDMESNCPGDTAEDHN
What are the official names of this protein?
G patch domain-containing protein 11, Coiled-coil domain-containing protein 75.
What is the protein family that this protein belongs to?
Belongs to the GPATCH11 family.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore.
Protein: VL2_HPV61
Sequence: MALKRRKRASATDLYRTCKQSGTCPPDVVPKVEGDTLADRILKWASLGVFFGGLGIGTGSGTGGRTGYVPIGTRPPTVVDIGPVSRPPVVIDPVGAADPSIVTLVEESSVIEAGATVPTFSGSGGFNVTSSSTTTPAVLDITPSGGSVQVSSTSFINPLFTEPSIIEPPQAGDLAGHVISSTPTAGSHSFEEIPMHTFATSEGPGSSTPLPGIRRLARPRLNLYSKANQQIKVANPTFMSDPASLITYDNPIFDPEETIIFEHPSIYTPPDPDFLDIVSLHRPALTSRQGTVRFSRLGQRATLRTRSGRRIGARVHFYHDISPIPSDAVELQPLVPSSSPSITYDIYADPEVLDLPAQHTQPTLTVQGPSLSAASASTKVHNVTVPLATGLDTPVTSGPDVDFAHAPAPVPAVPYVPATHPHSIYIQGSDFYLLPAYVFFPKRRKRVPYSFSDGFVAAW
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: RL5_POLNS
Sequence: MSTRFQEHYQSKVVADLIAKFGYKSVMEVPRITKVTLNMGLGDAVNDKKIIENAVGDLTKVAGQKPVVTKAKKAIAGFKIRQGYPIGAMVTLRSSRMYEFLDRFVTVALPRVRDFRGISGKAFDGRGNYNIGVKEQIIFPEIEYDKIDALRGLNISITTTAKTDEEAKALLAAFKFPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: SRP19_ORYSJ
Sequence: MDGGDLRSSIKKWNVIYPVYLNSKKTVAEGRRIASGKACPDPTCVEIADCCSHLKIPHAIELDKAYPRDFFQVGRVRVQLKKDDGSPVNPAIKTKKQLMIQIAELVPKHHGRTKKQEPAASSTAGTSKGKGGKKKK
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity).  Binds directly to 7SL RNA (By similarity).  Mediates binding of SRP54 to the SRP complex (By similarity).
What are the official names of this protein?
Signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.