PharMolix/UniProtQA huggingface dataset:
Protein: MATP_SALPA
Sequence: MKYQQLENLESGWKWKYLVKKHREGELITRYVEASAAQEAVNLLLALENEPVRVNVWIDRHMNPALLNRMKQTIRARRKRHFNAEHQHTRKKSIDLEFMVWQRLAGLAQRRGKTLSETIVQLIEDAEHKEKYATQMTTLKQDLQALLGKK
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSMD1_DICDI
Sequence: MVAINSVSNYLSLLDEDQLELKSYSLEKLDSCVDEFWSEIASSSIDKIKSLSVNKQFPKHELASLVLSKVYYNLSDFPNSMEYALSAGSLFNVLSKSEYIETLLYKFIDEYIKLRTSTNKDTVINPHLESIVMGMFDRCFKEGSYKQALGIAIEARRLDIIEKAISQSGNVNSMLSYCLHICNVSVNNRHFRHSVLGILVNLHLAQEKPDYLSVVQCLIFLDNHIEVATILLSLIKKDEESLLLAYQIGFDLFQNSTQQFLLNVRNRLPPVEKKSTTTTTTTPASDSMEIDIDSGNEKSGGSSSFEQRLERLHSILIGDVSIGMNLEFLYRNCSTDMHILQSMKTTSELHKGAIFYSGTLFANALMHAGTTRDTFLRSNIEWLYKSTHWTKFSAISSLGVINKGHIKESKSLLKTYLPGASVNQTPYSESGSLYALGLIHASHGEEIIDYLVEKLHINNAILHHGASLGLGLAAMATGRDDLYEDLKSVLYNDDAVSGEAAGLAMGLVMLGSGAKKAIEEMLAYAHETQHEKTIRSLSMGLAFLMYGKEESADTLIEQMIGDKDPLIRYGGMYAIAFAYCGTGHNDALRKLLHVAVSDGTDSVRRAAVTCIGFVLSRQPEKCPKAIALLAESYNPHVRYGAAFALGIACAGTGQRDALEILKSLTTDSVGYVKQAAWISMAMVLIQTSKELVPEAETARKLFATCISDKREDSMSKFGAVLAFGVIDAGGRNSTIQLHSPSGHKNMNAIVGIAGFLQFWYWFPMTHFMGLALTPTSIIGLNKNLEMPVFTFKSNCRPSLFAYPPETKPSTTSSTNKIETAILSYSRKNKLQSSRSAMNIDQDVEKKEKEEKEAKEKEAKEKEEKEAAKAEEKEPLFERKSNPARIVPRQLQYVQFDDARYQPIKKSPAIGIVMLRDLTPNEPEQLVVKEKPETKQETVGNQSGTATATASLPNATTTTSPTLPEPSTPEPFEFTE
What is the function of this protein?
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 1.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S1 family.
Protein: HAX1_HUMAN
Sequence: MSLFDLFRGFFGFPGPRSHRDPFFGGMTRDEDDDEEEEEEGGSWGRGNPRFHSPQHPPEEFGFGFSFSPGGGIRFHDNFGFDDLVRDFNSIFSDMGAWTLPSHPPELPGPESETPGERLREGQTLRDSMLKYPDSHQPRIFGGVLESDARSESPQPAPDWGSQRPFHRFDDVWPMDPHPRTREDNDLDSQVSQEGLGPVLQPQPKSYFKSISVTKITKPDGIVEERRTVVDSEGRTETTVTRHEADSSPRGDPESPRPPALDDAFSILDLFLGRWFRSR
What is the function of this protein?
Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484).  Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484).  Promotes GNA13-mediated cell migration.  Involved in the clathrin-mediated endocytosis pathway.  May be involved in internalization of ABC transporters such as ABCB11.  May inhibit CASP9 and CASP3.  Promotes cell survival.  May regulate intracellular calcium pools.
What are the official names of this protein?
HCLS1-associated protein X-1, HS1-associating protein X-1, HAX-1, HS1-binding protein 1, HSP1BP-1.
What is the protein family that this protein belongs to?
Belongs to the HAX1 family.
What are the subcellular locations of this protein?
Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Cytoplasm, cell cortex. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum. Cytoplasm, P-body. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited, and in response to cellular stress caused by arsenite (in vitro). SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro). SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm. Note=Predominantly cytoplasmic.
Protein: IMDH_TOXGO
Sequence: MADGWDAEKIFNTTVFGFTYDDLILMPGHIDFGVNDVDLSTRITRNLHVRTPIVSSPMDTVTEHRMAIGCALMGGMGVIHNNMETARQVAEVQKVKRYENGFILDPFVLRPSDSVADVYRIKEKYGYSSVPITDTGMLGGKLLGIVTSRDIDFLTDVHTPLSEVMTSDLVVGHEPVQLAEANELLRESKKGKLPIVNDNFELVALISRNDLKKNREFPLASKDSNKQLLVGAAVSTKPHDIERAKALQEAGADVLVVDSSQGDSIYQVDLVKRLKAAFPELQIIGGNVVTARQAKSLIDAGVDGLRIGMGSGSICTTQVVCAVGRAQATAVYHVCKYAREHGDVPCIADGGIQNSGHVMKALALGANAVMMGSMLAGTEEAPGEYYFHNGVRVKTYRGMGSLDAMRAGTRRTASPPARGLRSPEASPSTAASSGGASRASALSEASPSAKSEASRTSTSTGSAARYFAENQTIRVAQGVSGCVVDKGTVMQLIPYVIQGVKHGMQDIGARTLRDLHAQLVGGELRFDVRSGAAQREGDVHDLHSFERKLYA
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICT1_AILME
Sequence: MATAWCLPWTLRRAGAWLLTPPLRCPRRALHKQADGTEFQSIYSLDKLYPESRGSDTAWKVPDDAQQTNKDIPLDRLTISYCRSSGPGGQNVNKVNSKAEVRFHLATAEWIAEPVRQKMAIMHKNKINRSGELILTSECSRYQFRNLADCLQKIRDMIAEASQTPKEPSKEDAALHRIRIENMNRERLRKKRIHSAIKTGRRVDMD
What is the function of this protein?
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit.  Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation.  May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity).
What are the official names of this protein?
Peptidyl-tRNA hydrolase ICT1, mitochondrial, Immature colon carcinoma transcript 1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RECA_THEMA
Sequence: MPEEKQKKSVLEKALKRIEENFGKGSIMILGDETQVQPVEVIPTGSLAIDIATGVGGYPRGRIVEIFGQESSGKTTLALHAIAEAQKMGGVAAFIDAEHALDPVYAKNLGVDLKSLLISQPDHGEQALEIVDELVRSGVVDLIVVDSVAALVPRAEIEGAMGDMQVGLQARLMSQALRKIAGSVNKSKAVVIFTNQIRMKIGVMFGSPETTTGGLALKFYATMRMEVRRGEPIKEGKDVIGNVISVKIVKNKVAPPFKTAQTYIIYGKGIDREYELFNIAVNEGIVDRKGSWYYYTTLKGEEVSLGQGSSNAVQFLKDNPEIAGEIERRIREKYGLLSVEKEEQRKEKKSSGEEAS
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_PYRAR
Sequence: MPITTSAQPRKQRLALFNAPLHLRHKLFNAKLSPELEKKLGVKRLPVRRGDTVMILRGDFKGVTGKVVRVDLKKVRIYVEGATRTNSRGQTVYYPIHPSKVMIVDVDMSDKARQKIIERRKK
What is the function of this protein?
Located at the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: CYSW_SYNE7
Sequence: MVAFVKARRQIAGVKESKSLLPLALIGISLLYVGLIIIIPAANVAVQAFSEGLSGFIKNLGDRNLQEAIRLTLLMGVISVPLNTLFGLAAAFAIARKQFPGKSLLLSVIDLPFSISPVVAGLMIVLLYGRNGWLGPLLESNDIKIIFAWPGMALATIFVSMPFVAREVIPNLEEIGTDAEEAASTLGANGWQTFWRVTLPSIKWSMLYGVVLTTARALGEFGAVSVVSGSITGKTQTLPLFVEEAYKQYQTTLSYTAALLLGGISLVTLVLKALLEARTGRQSRIH
What is the function of this protein?
Part of the ABC transporter complex CysAWTP (TC 3. A. 1. 6. 1) involved in sulfate/thiosulfate import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Sulfate transport system permease protein CysW.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EFEMO_STAAR
Sequence: MKKLTTLLLASTLLIAACGNDDSKKDDSKTSKKDDGVKAELKQATKAYDKYTDEQLNEFLKGTEKFVKAIENNDMAQAKALYPKVRMYYERSEPVAEAFGDLDPKIDARLADMKEEKKEKEWSGYHKIEKALYEDKKIDDVTKKDAQQLLKNAKELHAKADTLDITPKLMLQGSVDLLNEVATSKITGEEEIYSHTDLYDFKANVEGAQKIYDLFKPILEKKDKKLSDDIQMNFDKVNKLLDKYKDNNGGYESFEKVSKKDRKAFADAVNALGEPLSKMAVITE
What are the official names of this protein?
Efem/EfeO family lipoprotein.
What is the protein family that this protein belongs to?
Belongs to the EfeM/EfeO family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: AKRC9_ARATH
Sequence: MANAITFFKLNTGAKFPSVGLGTWQASPGLVGDAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFEDRVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPARIKKGSVGIKPENLLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELARVPPAVNQVECHPSWRQTKLQEFCKSKGVHLSAYSPLGSPGTTWLKSDVLKNPILNMVAEKLGKSPAQVALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSIPDYMFAKFAEIEQARLVTGSFLVHETLSPYKSIEELWDGEI
What is the function of this protein?
Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids (PubMed:19616008).  Aldehyde reductase that catalyzes the reduction of the aldehyde carbonyl groups on saturated and alpha,beta-unsaturated aldehydes (PubMed:21169366).  No activity on alpha,beta-unsaturated ketones (PubMed:21169366).  Can use propionaldehyde, butyraldehyde, methylglyoxal, (E)-2-pentenal, (E)-2-hexenal, (Z)-3-hexenal and (E)-2-nonenal as substrates, propenal (acrolein), crotonaldehyde, but not 2-butanone, 3-buten-2-one or 1-penten-3-one (PubMed:21169366).  May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress (PubMed:19616008).
What are the official names of this protein?
NADPH-dependent aldo-keto reductase, chloroplastic, AtChlAKR, Aldo-keto reductase family 4 member C9.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CYB_MYOYA
Sequence: MTNIRKSHPLMKIINSSFIDLPAPSNISSWWNFGSLLGICLALQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWILRYLHANGASMFFICLYLHVGRGLYYGSYMYTETWNVGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGINLVEWIWGGFSVDKATLTRFFTFHFLFPFIVAAMVMVHLLFLHETGSNNPTGIPSNTDMIPFHPYYTIKDVLGLLLMITALLMLVLFTPDALGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILIIIPLLHTSKQRSMSFRPLSQCLFWLLVADLLTLTWIGGQPVEHPYVIIGQLASILYFSIIIILMPLISLVENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YL888_MIMIV
Sequence: MKPQKIIYKIEEFPAIHYLHNALTKNYDVIFKYSENIINNKKVSQIKRIPGQWTGQKADDFVNGLDDTWIYGWTDQNTWFNYLMIYNNHIINNGDDMDNQIINDIFIPIKSIINICGLSLLMPEATIKPHIDENTTISKNRLAYHFNVFGNGSIININGILLKQKPKKSLVFDSGFIHSVTNGNEYRLLIYIDFNVLLSKNFIYGRITDLSNDKIIIKSYYKHDNGIYNINHYNYGQGLATVSQYTVSLMFNNQRSDILKNDSILIEIISS
What are the official names of this protein?
Uncharacterized protein L888.
Protein: Y1020_PYRFU
Sequence: MQLGFAMLADPILLITILLGFAMAWAIGANDAANSMSTAVGAGAITPRQAVIIAGVLEFMGAYFFGKTVTETIRKGIIDPSKITDPNVLIFGSIAALIGATIWLVIATKYGLPVSTTHSIIGGIVGYGIVYGGMSIVNWDKMIKVVLSWILSPIVGAIFAYLVFRALSKTVLQSKDPVKSAKRWSPFWIGLAFVVIGTMFYIKVLHGNSLLEGFLKYGMPAGILTFIVVSLILEKRFPATDPYLGAERVFRRVQVITSAYVALAHGANDVANAIGPVAAVYTVAMFGLAGAKVPVPRWILALGGLGIAIGVATYGYKVMETVGKKITELTNTRGFTIDFSAATVVLIASWLGMPISTTHTVVGAVIGVGLARGIKAINKDIVKDIIISWFVTVPAAGVIAGIIFKALMMLMG
What is the function of this protein?
Potential transporter for phosphate.
What are the official names of this protein?
Putative phosphate permease PF1020.
What is the protein family that this protein belongs to?
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRXB_PEPLI
Sequence: MENVYDIAIIGSGPAGLAAALYGARAKMKTLLLEGMKVGGQIVITHEVANYPGSVPEATGPSLIGRMEEQVEEFGAERVMDNIVDVDFTDKIKVLKGAKGEYKAKAVIVATGASPKLAGCPGEKELTGKGVSYCATCDADFFEDMEVFVIGGGDTAVEEAMFLTKFARKVTIVHRRAELRAAKSIQEKAFKNEKLNFMWNTVIEEIKGDGIVESAVFKNRETGEVTEFVAPEEDGTFGIFVFIGYDPKSALVEGKLELDETGYIPTDDNMKTNVEGVFAAGDIRVKSLRQVVTATADGAIAAVQAEKYIEELFAE
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_METI4
Sequence: MNKLKTDLNLIWNDICLELQKVISKEAIEKWFVPIELLSIENDQLLLKAPDPIYQYWIEENYLSQLIGASFRILAKNPKIIFAQESPGNGEKATGKKIKSLPREDKSSIFESKGLNTKFSFENFVVGPNSEFAAAAAKAVAESPAKAYNPLFLYGKVGLGKTHLMQAIGNHIVEKNKWILVQYVTSEQFTNEFIEAIQKGSIGQFRKKYRQIDVLLIDDIQFLAGKERSQEEFFHTFNCLFDGSKQIVLSGDEAPSSLQNLEKRLISRFEWGLTAEILPPGIEVRLAILKHKLKNYSLSIDEKILEFIAERIKTNVRQLEGALNRLCAYASIHKEGKITLEETQSLLKDLISLQPSKTITIEMIQKRVCEAYDIRFSDMVSKRRISAIALPRMVAMYLARRLTNLSLSQIGENFGGRDHGTVLHAQRTISEKMSKDPDLAQLIKKITEQLTSSQ
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRQ_XANOM
Sequence: MAKTSTSVIVAKTLVHAAALAPIALLGWQFWQVWQSGSDALGADPVAEIEHRTGLWALRFLLITLAITPLRQLTGQAVLIRFRRMLGLYAFFYATVHLAAYLTLDLRGFWTQIFEEILKRPYITVGFAAWLLLMPLAITSTQGWMRRLKRNWGRVHMLIYPIGLLAVLHFWWLVKSDIREPALYAGILAVLLGWRAWKKLSARRTKARRSAPPQATPR
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLNA_DUNSA
Sequence: KAQEPWFGIEQEYTLLNSVTKWPLGWPKGGYPAGQGPYYCSVGAGRSIGRDIPEVHYRCCLHAGIQISGVNGEVLPSQWEYQVGPVEGIAMGDQMWMSRYLMYRVAELFNVEVTFDPKPIPGDWNGSGGHVNFSNRQPESPPAGKQSRSSAKKLGKRHRWHIAAYGEGNERRLTGKHETSSMNDFSWGVANRGCSIRVGRMVPVEKCGYYEDRRPSSNLDPYVVTRLLVETTLL
What are the official names of this protein?
Glutamine synthetase, Glutamate--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTX_CORBE
Sequence: MLVRGYVVSRKLFASILIGALLGIGAPPSAHAGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYAVSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKS
What is the function of this protein?
Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2).  Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.
What are the official names of this protein?
Diphtheria toxin, DT, NAD(+)--diphthamide ADP-ribosyltransferase.
Protein: MTNB_YERPB
Sequence: MTENRQLGALLAACHWIGEKGWCPATGGNMSLRLDLAHCLITESGKDKGSLAAEDFLLVETANNHVPSGRTPSAETGLHTLLYRLYPEIQAVLHTHSVNATVLSRVERSNALVLQGYEMQKSLSGQRSHLDAVVIPIFDNDQDIPVLAQRVAAYADNRPLQYGFLVRGHGLYCWGNSVVEARRHLEGLEFLFQCELQRRLFDVNSNVDVKPNVDVNPNVEAK
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: SYFA_CLOBH
Sequence: MRQKLEEIKNSAINELKTTLSKDQLEAIRVKYLGKKGELTQILRGMGALSQEERPIVGKVANEVRSYIEETIKEAFSDIKNKEKSIRLENETIDITMPGKKQAVGKRHPLDLTLESMKDIFISMGFTIEEGPEVELDKYNFEALNIPKNHPARGEQDTFYINDNLVLRTQTSPIQIRTMENQKPPIKMIAPGKVYRSDSVDATHSPIFYQMEGLVVDKGITFSDLKGTLELFAKRMFGDKVKTKFRPHHFPFTEPSAEMDATCFVCNGEGCKVCKGSGWIELLGCGMVHPQVLRNCNIDPEVYSGFAFGFGVDRMVMMKYGIDDIRLLYESDMRFLNQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBX2B_HUMAN
Sequence: MAEGGGPEPGEQERRSSGPRPPSARDLQLALAELYEDEVKCKSSKSNRPKATVFKSPRTPPQRFYSSEHEYSGLNIVRPSTGKIVNELFKEAREHGAVPLNEATRASGDDKSKSFTGGGYRLGSSFCKRSEYIYGENQLQDVQILLKLWSNGFSLDDGELRPYNEPTNAQFLESVKRGEIPLELQRLVHGGQVNLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAVVLIDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRNFIVQSRPEFAALDFILVTSFPNKELTDESLTLLEADILNTVLLQQLK
What is the function of this protein?
Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156).  Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156).  The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156).  VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156).  Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807).  Also, regulates spindle orientation during mitosis (PubMed:23649807).
What are the official names of this protein?
UBX domain-containing protein 2B, NSFL1 cofactor p37, p97 cofactor p37.
What is the protein family that this protein belongs to?
Belongs to the NSFL1C family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosome during mitotic prophase and metaphase.
Protein: TRPA_MARN8
Sequence: MSRIEGVLKALKEQGRKALIPYITAGDPHPEETVSLMHTLVSAGADIIELGVPFSDPMADGPVIQLACERALKHGTSLRQVMAMVKEFRKTDPDTPVVLMGYLNPMEAMGYEAFADAAADAGVDGVLTVDLPPEEADQVAPLFADRHLDPVFLLAPTTTDERIKAISEHSSGYVYYVSIKGVTGSATIDVDEVAKKVAHVHELTALPVGVGFGIRDAETAAAVGRVSDGVIVGSVLVDTIARHQTDPDALRNALTDLLHPMREALDSLAH
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: NU2M_HYLLA
Sequence: MNPLAQPIIYSTIFAGTLITASSSHWFLTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLVQATASMILMMAILSNNLLSGQWTMANITNQYSSTMMLMALAMKLGMAPFHFWVPEVTQGTTLMSGLLLLTWQKLAPISIMYQIFPVVNVNILLAFSILSIMVGSWGGLNQTQLRKILAYSSITHVGWMMAVLPYNPDITIFNLIIYIVLTTTAFLALNLNSSTTTLLLSRSWNKLTWLLPLIPSTLLSLGGLPPLTGFLPKWLVIEELTKNGTLIIPTAMAIITLINLYFYMRLIYSTSITLLPTSNNVKMKWQFENTKPTFLLPTLMTLTTLLLPIAPLTFPTP
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS14_BURVG
Sequence: MAKLALIEREKKRARLVAKFAAKREALKAIVEDQSKSEEERYEARLELQQLPRNSNPTRQRNRCAITGRPRGTFRKFGLARNKIREIAFRGEIPGLTKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: MBTP2_BOVIN
Sequence: MIPVSLVVVVVGGWTAVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLIQTLGQMMADSSYSSSSSSSSHSSSSSSSSSSSSSLYNEQVLQVVVPGINLPVNQLTYFFAAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFILALLGILALILLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTITYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRTNKDCKKSSSSSFCIIPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFKFLSIDLPVVVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSILLAANVALGLWMVTAR
What is the function of this protein?
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2.  Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached.  Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription.  Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B).  Involved in intramembrane proteolysis during bone formation.
What are the official names of this protein?
Membrane-bound transcription factor site-2 protease, Endopeptidase S2P.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50A family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cytoplasm.