PharMolix/UniProtQA huggingface dataset:
Protein: ISCS_CLOBH
Sequence: MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALNAEKNEIFFTSGGSEADNWAIKGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTYLPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPIKEIGELCKEKNIYFHTDAVQAIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTENTAGIVGLGKAIELAMENMPEENEKLSNLRGRLIRGIEARIPEVKLNGPKDMSRRLPNNVNFSFIGIEGETLLLDLDMNGIFGSTGSACASASLDPSHVLLSIGLPHETAHGSLRLSLGAKNTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10E_SULIK
Sequence: MPLRPGRCYRHFSGPAYTRKEYIPGIPQPKITKFTSGNPNGDYDYEVRLITTEIGQIRHNALEAVRTITLKTLTKRTGSETSFFMWILKYPHHVLRENKMMAFAGADRLQDGMRLSFGTPIGTAARIEKLGEILIVVKVKKEHLDFAKEALKIASKKLPLRTRIEIIPLRPIRQEVQS
What are the official names of this protein?
50S ribosomal protein L10e.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: GPH_XYLFT
Sequence: MPLNEVSGNAFPRTVLFDLDGTLLDSAPDMLATANAMLAARGRAPITLMQLRPVISRGTFRIIAVAFPELDAAAIQGLIPEFLQRYEALIGSVSKPFDGVEMMLHALECAGTVWGIVTNKPEFLARLILPLLGWTSRCAVLIGGDTLAERKPHPLPLLTAAERIGVMPTDCVYVGDDVRDIQAARAAGMPSMVALWGYRSHEDNPMTWQADTLVEQPHLLSRPDVWPST
What is the function of this protein?
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.  Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: PSB28_TRIEI
Sequence: MTTIQFIQGIDEEVTPEVRLTRSRSGNQGTATLIFEDPKALGQDVTQEITGMYMIDEEGQITSRDVKARFVNGQPKFLEGLYVMKTKQEWERFMRFMESYAKEHDLGFKKAKA
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS16_PROMM
Sequence: MIKLRLKRFGKKREASFRLVACNSTSRRDGRPLQELGFYNPRTKETRLDTEALRLRLSQGAQPTDAVRSLLEKGGLIEKTVRPAEVVGKAKQAEARKAAAKNVAKQAAEAKAEETPADNTEA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: DPH1_CANAL
Sequence: MSPVEKPVEVEKPKVPKRRFVGKKPQNITIKDGEQPLTKTINPARHIGRVMNQIPDDILNDKELNEAIKLLPSNYNFEIHKTIWNIRKTNCKRVALQMPEGLLIYSLIISDILEQFCQVETIVMGDVSYGACCIDDYTARSLDCDFIVHYAHSCLVPIDITSIKVLYVFVTINIDETHLINTIKLNFERGTQIAIFGTIQFNPTIHSVKAKLENDTEKPMYLIPPQTRPLSKGEVLGCTSARLDKEHIKAMIYIGDGRFHLESSMIHNPEIPAYRYDPYSRKFTREYYDHKQMIDVRKDAISTTKYATKVGLILGALGRQGNPITLDKLEKSLSEKGIQVVKIILSEILPQKLAMFDDVDAFVQVACPRLSIDWGYAFNKPLLTPYEAMVMLEKDTMGDEKVYPMDYYSKDGYGRGSIPDHSHLTT
What is the function of this protein?
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1, Diphthamide biosynthesis protein 1, Diphtheria toxin resistance protein 1, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_CHLP8
Sequence: MNIHEYQGKGILKQFGVAVPKGIVAFSAEEAKQAAAELFEEQSSPVVVVKAQIHAGGRGKAGGVKLAKSPEEVYEIAQKMLGTTLVTHQTGPEGKEVRRLLIEEGMNIDKEFYLGITLDRATSCNVLMVSTEGGMEIEKVAEETPEKLLKIQVNPKYGLQGFQAREAALFLGMQGEQFRNGVKFIDALYKAYTTIDASLAEINPLVVTKEGRVLALDAKINFDDNAMYRHPDFHELRDITEEDPLEYEASKSNLNYVRLDGNVGCMVNGAGLAMGTMDLIQLAGGKPANFLDVGGGASPKTVEEGFKIILGDKNVKAILVNVFGGIVRCDRVAGGVIEAAKNIGLTVPVIVRLEGTNAKEAQKMLDESGLSLIAANGLRDAAEKVQKALASA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: MLH3_YEAST
Sequence: MSQHIRKLDSDVSERLKSQACTVSLASAVREIVQNSVDAHATTIDVMIDLPNLSFAVYDDGIGLTRSDLNILATQNYTSKIRKMNDLVTMKTYGYRGDALYSISNVSNLFVCSKKKDYNSAWMRKFPSKSVMLSENTILPIDPFWKICPWSRTKSGTVVIVEDMLYNLPVRRRILKEEPPFKTFNTIKADMLQILVMHPMISLNVQYTDKLRINTEVLFRSKNITEGLTKHQQMSQVLRNVFGAIIPPDMLKKVSLKFNEYQIEGIISKMPVGLKDLQFIYINGRRYADSAFQGYVDSLFQAQDFGEKGMSLLKTKSVGKPYRSHPVFILDVRCPQTIDDLLQDPAKKIVKPSHIRTIEPLIVKTIRSFLTFQGYLTPDKSDSSFEIVNCSQKTATLPDSRIQISKRNQVLNSKMKIARINSYIGKPAVNGCRINNSTINYEKIKNIRIDGQKSRLRNKLSSRPYDSGFTEDYDSIGKTITDFSISRSVLAKYEVINQVDKKFILIRCLDQSIHNCPLLVLVDQHACDERIRLEELFYSLLTEVVTGTFVARDLKDCCIEVDRTEADLFKHYQSEFKKWGIGYETIEGTMETSLLEIKTLPEMLTSKYNGDKDYLKMVLLQHAHDLKDFKKLPMDLSHFENYTSVDKLYWWKYSSCVPTVFHEILNSKACRSAVMFGDELTRQECIILISKLSRCHNPFECAHGRPSMVPIAELK
What is the function of this protein?
Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis.  Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches.  This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.
What are the official names of this protein?
DNA mismatch repair protein MLH3, MutL protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPP_LEGPC
Sequence: MPGYSDYIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQLLFLESENPEKDISLYINSPGGVVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGAEGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRERLNNIMAKHTKKTPDQIMRDTERDNFMSATQAMEYGLIDKVLYDRQVAGHSTDL
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COF_SALA4
Sequence: MARLAAFDMDGTLLMPEHHLGRETIATLARLRERDITLTFATGRHVLEMRHILGTLSLDAYLITGNGTRIHSLEGDVLHRQDLDPQVADTVMHHAWDTRASMHVFNDNGWFTGQEIPALLQAHVYSGFRYQVIDIKSIPAHQVTKICFCGDHDDLIRLRIQLNEALEERAHLCFSAVDCLEVLPLGCNKGSALAVLSNHLGLSLADCMAFGDAMNDREMLGSVGRGLIMGNAMPQLIAALPHLSVIGHCGNQAVSHFLTHWLDNPHLPYSPE
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: MOBA_BACAN
Sequence: MSKYAGIVLAGGMSSRFGEPKALASWQGSTFIEHILKVMTSTLQEVVVISHSDIKERVEKLVQVPVIEDIPHYKGNGPLAGIVSGMEYIEADWYAIMPCDAPNVSHEWFTILLEQTSNEYDAVVPIINGRKQPLLAAYHNRVKEKIYALLQDEKRSMGQLLSQCNVKYVSGEDVQANADWFINVNTKEEYVQAQKDLSNK
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Probable molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHP6_DICDI
Sequence: MSSSDESGSSSSESEKKVKKTPVKKPKKEPKVSKKGKKEGKKTKKKPKDENAPRRYLSPFIFFSKDHRSVIKNSHPNCSFGEIGSLLGQEWAKISAEDKKKYEKLAAEDKKRWELEKKNYDEKLKTQSQAESSSDSSDESD
What is the function of this protein?
DNA-binding protein that induces severe bending of DNA.  Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair (By similarity).
What are the official names of this protein?
Non-histone chromosomal protein 6 homolog.
What is the protein family that this protein belongs to?
Belongs to the NHP6 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DAPE_PSEPG
Sequence: MTAPAELSPTLQLACDLIRRPSVTPVDADCQAQMMNRLGAVGFELEPMRIEDVDNFWATHGSQDGPVLCFAGHTDVVPTGPVQQWQHEPFEALIDADGMLCGRGAADMKGSLASMVIASERFVQDYPNHRGKVAFLITSDEEGPAHHGTKAVVERLKARNERLDWCIVGEPSSTTLLGDVVKNGRRGSLGAKLTVRGKQGHVAYPHLARNPIHLAAPALAELAAEHWDEGNAFFPPTSFQISNLNSGTGATNVVPGELTALFNFRFSTESTVEGLQARVSAILDKHELDWSIDWALSGLPFLTEPGELLDAVASSIKGVTGRDTQPSTSGGTSDGRFIATMGTQVVELGPVNATIHQVDERILASDLDLLTEIYYQTLVRLLA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: COAE_SYNJB
Sequence: MRIIGLTGGVGTGKSTVARILEQHGIPVADADQMARQALAVGSPIRERVLERYGKVIQTPSGDLDRRRLGQIVFADAAERAWLEAQIHPFVRAQLQDFLSALAEQSSKVHGVPLEEEPASQKRSGVGFSSGQGSQTVCLMIPLLFEAHMENWASEIWVVTCTPEQQRQRLARRDPLTPEEIEARIASQWPLAEKVRRADVVLDNSGSLAELEAQVKQALASAGQRPFASPPRAGYSDG
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMP1_YEAST
Sequence: MDEMDNVIRSLEQEYRLILLLNHRNKNQHRAASWYGSFNEMKRNCGQIITLFSSRRLQAKRLKDVEWVKLHRLLQRALFRQLKRWYWQFNGVIALGQFVTLGCTLVTLLANVRALYMRLWEINETEFIRCGCLIKNLPRTKAKSVVNDVEELGEIIDEDIGNNVQENELVITSIPKPLTENCKKKKKRKKKNKSAIDGIFG
What is the function of this protein?
Functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria.
What are the official names of this protein?
Ribonuclease MRP protein subunit RMP1, RNA-processing protein RMP1, RNase MRP 23.6 kDa subunit.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Cytoplasm. Nucleus.
Protein: SBMC_ERWBE
Sequence: MNVEIVEREESKTAGFHLVGPWEVTAPEGFDKLVAWTSKHNVMGPWMGVYHGNPRAVPAEELKIETVIGVPTDFELPEGSEGARLSIIPAGTYAMNLVHVNDGDFTKPWYAFFDEWLPDSGYVMAEGPCFDHYLNDGSQSGEWDIELYIPVSKAE
What is the function of this protein?
Inhibits the supercoiling activity of DNA gyrase.  Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase.  It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
What are the official names of this protein?
DNA gyrase inhibitor.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFA73_MOUSE
Sequence: MAVTWEEYFRLVFSEKVQPKPLEQTGDDSSVLQLILEKKEELAVADLGLQAQKKEYRSTIESVNQRWRELEQKGQELQGSVISYDKFLKEVEARRAARKAIEERKITGNLDAELRRLRTQLKELRLQRARLQRKVQRLEPCARILKRALEKRPVFEEVSDLVARFETLVSTKAALKLEEQKRLVEMESTRAQLLSLQSEKQDEMLNLNQQRTQLVEQLEAAREHRQQWESKWTEILNSASEKTLLLGRARMAVLNLYHLVRLQQGRRQTLDVRDVEGQLEEVKRFIMNISATLAKLALAQPTATAS
What is the function of this protein?
May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.
What are the official names of this protein?
Cilia- and flagella-associated protein 73, Coiled-coil domain-containing protein 42B.
What is the protein family that this protein belongs to?
Belongs to the CFAP73 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: HTPG_HELPJ
Sequence: MSNQEYTFQTEINQLLDLMIHSLYSNKEIFLRELISNASDALDKLNYLMLTDEKLKGLNTTPSIHLSFDSQKKTLTIKDNGIGMDKSDLIEHLGTIAKSGTKSFLSALSGDKKKDSALIGQFGVGFYSAFMVASKIVVQTKKVTSHQAYAWVSDGKGKFEISECVKEEQGTEITLFLKEEDSHFASRWEIDSVVKKYSEHIPFPIFLTYTDTKFEGEGDNKKEVKEEKCDQINQASALWKMNKSELKEKDYKDFYQSFAHDNSEPLSYIHNKVEGSLEYTTLFYIPSKAPFDLFRVDYKSGVKLYVKRVFITDDDKELLPSYLRFVKGVIDSEDLPLNVSREILQQNKILANIRSASVKKILSEIERLSKDNKNYHKFYEPFGKVLKEGLYGDFENKEKLLELLRFYSKDKGEWISLKEYKENLKENQKSIYYLLGENLDLLKASPLLEKYAQKGYDVLLLSDEIDAFVMPGVNEYDKTPFRDASHSESLKELGLAEIHDEVKDQFKDLIKAFEENLKDEIKGVELSGHLTSAVALIGDEPNAMMANWMRQMGQSVPESKKTLELNPNHAILQKLLKCEDKEQLSAFIWLLYDGAKLLEKGALKDAKSFNERLNSVLLKAL
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_RICAH
Sequence: MQYQTHWIEHSVVKILSTTGKNHIALVAGGMSAEREVSLVSSEGVQQALIALGYKVTFIDMGADIAVKLQEIKPDIVFNCLHGTYGEDGCLPGLLNIMRIPYTHSGVLSSALAFNKIHSSSWFFANSINTAESIVVSKSYNINTDPMKRPYVIKPLTQGSSIGVEVIFEEDDFNFADYDFPYGDQVVIERYIKGREFQVAVLNSKALGALEIKLIKNRFYDYETKYTEGFAEHLCPAPLHANLYEKLLIESEKIYKTMNCKGPARAEFILEEQTNKLYALEINTHPGMTPLSIVPEIAAYAGINFTNLIAEIIKTASFES
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQ7_ACIBS
Sequence: MRHYTGIDQLINSFDQALRSLVPGATAAQRQNPAETVEAKLGVEDARHVAGLMRVNHSGEVCAQALYHGQALTAKLPNVRREMQQAAIEEQDHLAWCEDRLKELNSHTSLLNPIWYGLSYGMGALAGIAGDKYSLGFVAETERQVSLHLQDHLNQLPAQDERSRKILEQMNEDELHHRHTALEAGGVELPYAVKITMTAISKLMTKTSYYL
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PRMA_LACP3
Sequence: MNDWTALTVTTTTEAIEAVSNILMEAGAVGIQIKDAADFKKETVDAHGTWFDPKTVPHLASGAQVIGYFDPATSLVEQRDHIATRVRGLAQFGLDPGAATVTLADVRQADWANVWKQYYHPLRVSRFLTIVPKWEHYTPQQAGELQLTLDPGMAFGTGTHPTTQLMLSLLESVIRGGETMIDVGTGSGILAIAAERLGVGDILATDVDEIAVRNAEANIKLNPVSHITVIANDLLKGITLSADLIVANILAEVLVPLIPQVRPRLKAHGHFLLAGIIANKATLIIRTLEDNGFSIAQRREAGGWVALDAVIKETA
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAF1_RAT
Sequence: MKLLENSSFEAINSQLTVETGDAHIIGRIESYSCKMAGDDKHMFKQFCQEGQPHVLEALSPPQTSGLSPSRLSKSQGGEDESPLSDKCSRKTLFYLIATLNESFRPDYDFSTARSHEFSREPSLRWVVNAVNCSLFSAVREDFKALKPQLWNAVDEEICLAECDIYSYNPDLDSDPFGEDGSLWSFNYFFYNKRLKRIVFFSCRSISGSTYTPSEAGNALDLELGAEEVDEESGGGGGGGEGRAEETSTMEEDRVPVICM
What is the function of this protein?
Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity).  Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity).  Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB.  When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription.  Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout.  Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (By similarity).
What are the official names of this protein?
Repressor of RNA polymerase III transcription MAF1 homolog.
What is the protein family that this protein belongs to?
Belongs to the MAF1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: HXKL2_ARATH
Sequence: MTRKEVVLAVTAATITAVAAGVLMGRWIRRKERRLKHTQRILRKFARECATPVSKLWAVADALVADMTASLTAECCGSLNMLVSFTGSLPSGDEKGVHYGVNLRGKELLLLRGTLGGNEEPISDVQKHEIPIPDDVLNGSFKELCDFISLELVKFLAMNPGGEAEEVKNLGFTLTRSVEQIGSHSISSIHRKSLANDDDEKVLKDLVNDMNESLETHGLKIRMNTALVDNTIGELAGGRYYHKDTVAAVSLGMGTNAAYIEQAQEISRWKSAIREPQEIVVSTEWGDFRSCHLPITEFDASLDAESLNPGHRIFEKMVSGRYLGEIVRRVLLKMSEESALFGDTLPPKLTIPYILWSPDMAAMHQDISEERETVNKKLKEVFGIMDSTLAAREVVVEVCDVVAERAARLAGAGIVGMIKKLGRLEKKMSIVIVEGGLYDHYRVFRNYLHSSVWEMLGDELSDHVVIEHSHGGSAAGALFLAACGDGHQDSESK
What is the function of this protein?
Fructose and glucose phosphorylating enzyme.
What are the official names of this protein?
Probable hexokinase-like 2 protein.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: BXJ_ENTS3
Sequence: MVTINDLHYSDPIDEDNIINMRIPLYDLEVDDQFINHNVPDLKAFQVFPNVWVVPERYTFYSTMKNLDAPANPSRSSYYDPTYLQSDAEKEVFLQQMILLFKRINSTQEGQQFLNLLSRSIPVPYESNGDVAMGTTQVIKQMDDKGNVLKHRRAHIIIYGPGPDLMAKGSKALTKSRETGRGCMAEIYFSPMYHKTYSTKLTNKNSLVDKSVQEFVPDPAVTLIHELCHGLHALYGIDLGNVGSWEFNSNPNSLFSSWFSSKEAVNFEEVMTFGGEDVKVIKSEIDKKIPGILNLIKTTVEPIINKITDPHDEMLQCLQSKYPSLKGTLGQFFFDDTQLEKDIRDLWMVMNETMFAENLKALTRARYLVPKVENIVQVDILSPNVYTIDKGFNHLSKGFKGQSVSQSYFRKISALARGAVVRACPNPHFSSQRGLSSCIEILEDDLFIMSSKDSFTDTDFSEPSVGPVSYKAKKGADTILDSTLSNYDFSKEINFTSTVPIITVEDPLETDEDVPVISEDRTVYVDDYTTFHFLEAQKIGKEVVPTQTKVVFTTNMEEALFDSKKVYTVFENTASRINEAGTGIANGMMFYQWLKGIVQDFTEEATQKDTFDKISDVTMIVPYLGNILNIGNDIRKGDFMGAVELGGVTILLEAIPELTLPVLIGLTIIEDELEKEQVSQTVYNVLDKRDEKWEEVYGFVKQQWWWMVHTQFETRILHAYQALNHQVEAIKANMTYQLANYRGNQEDKELLEKAIDDTLQSLYYAVDQAMHNIKRFLIQSSKSYLLNQMLPKTKEQLLAFDQQTLRNVNDFINKNQGVLGESLAKDLKKKVEKRLTSLPVFNLEDLPISEFEDLIHSHEIDIQDSEVLNIGVNNGKIQDLSGENTPLTLGENLHIVNGRDNQAVRLNNQLDSKLEIQSRPNIHFTAFEDFSISIWIRCSMLRNNRNRGQKYTIIQQFNKYGWQLAIQDSVFVWTLHDTFNNQIQLTSGSALTNKNYLLQNFWLHITVTNKRSEKSRLYINGVLQDQKDISVLGNCHPKEPILFSIQDNSDPNYFVRFEQFNVYRKALTDSEVNRLYWKYFEGSYLRDVWGERLTYNRDYYMQLSTLPGRGIKREYRTWSGFDYIILSELGTQKIPTHEVTYPKLYQGQKITIHSDGKNLEPHVKSNKNIRLKIDDFYIGVVNPFKLPEWRPESGAYVVTTYNHAEDLCLYFRTRSSSQSLYYGQLIMNDGRNKSLLNYTLKGSTYWIWSSAWYYENYNTSSKTAGNWYFIPVDEGWKED
What is the function of this protein?
Strongly resembles a botulinum-type toxin, with the appropriate domains and residues to have proteolytic function, although its C-terminus (which binds to a eukaryotic host cell) is different enough from clostrial botulinum toxins that it might bind another cell target (PubMed:29323697).  Might be a precursor of a toxin that binds to an unknown eukaryotic cell receptor(s), and be taken up into the host cell via the endocytic pathway.  When the pH of the putative toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the heavy chain forms pores that allows the light chain to translocate into the cytosol.  Once in the cytosol the disulfide bond linking the 2 subunits is reduced and light chain cleaves its target protein (By similarity).
What are the official names of this protein?
Botulinum-like toxin eBoNT/J, eBoNT/J.
What is the protein family that this protein belongs to?
Belongs to the peptidase M27 family.
What are the subcellular locations of this protein?
[Botulinum-like toxin eBoNT/J]: Secreted. SUBCELLULAR LOCATION: [Botulinum-like toxin eBoNT/J light chain]: Secreted. Host cytoplasm, host cytosol. SUBCELLULAR LOCATION: [Botulinum-like toxin eBoNT/J heavy chain]: Secreted. Host cell membrane. Host cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: Y272_MYCPN
Sequence: MNRPTPNFEAIDKKISAFVTNHDNLLDKLLKQQTELLTSEITTNFEVTQQIQEEVAKKTKQHSKNYKWLVTVVLANGVVSLFLLGGLIYLFSK
What are the official names of this protein?
Uncharacterized protein MPN_272.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MNMG_SALCH
Sequence: MFYQDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVSRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASQHPQQVPCYITHTNEKTHDVIRNNLDRSPMYAGVIEGIGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFIHGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEMGRELGLVDDERWARFNEKLENIERERQRLKSTWVTPSAESADEVNAHLTTPLSREASGEDLLRRPEMTYAQLTSLAAFAPALEDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPVAISILLVWLKKQGMLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.