PharMolix/UniProtQA huggingface dataset:
Protein: DAZP2_PONAB
Sequence: MNSKGQYPTQPTYPVQPPGNPVYPQTLHLPQAPPYTDAPPAYSELYRPSFVHPGAATVPTMSAAFPGASLYLPMAQSVAVGPLGSTIPMAYYPVGPIYPPGSTVLVEGGYDAGARFGAGATAGNIPPPPPGCPPNAAQLAVMQGANVLVTQRKGNFFMGGSDGGYTIW
What is the function of this protein?
In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 (By similarity).  In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters (By similarity).  This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death (By similarity).  Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (By similarity).  Plays a role in stress granule formation (By similarity).
What are the official names of this protein?
DAZ-associated protein 2, Deleted in azoospermia-associated protein 2, Proline-rich transcript in brain protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.
Protein: HSLO_HAEDU
Sequence: MQHIQDNDKLYRYLFQHRAVRGEWVRLNETFSQTLNTHQYPKAVQHLLGEMLVATSLLTAIMKFEGNITVQIQGDGPLKLAVVNGNEKQQLRALARVQAEIDDQASLAEMVGNGVLVISIIPTEGERYQGVIQLDKPTIRECLEDYFIRSEQLQTHLIIRVGEYAGQAVAAGMLLQIMPDGTGTPEDFEHLMTLAETVKDEELFGLTAEALLYRLFHQEQVEVYPAQTTAFKCGCSRERSGQAMLLLPMAEIEEMLAEKKGVIDMQCECCGTQYFFDKPAIMLLKEEAAKLADLGLT
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEE_ECO8A
Sequence: MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAIHTAAFALPQYLQDALASQPS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNJA1_HUMAN
Sequence: MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
What is the function of this protein?
Co-chaperone for HSPA8/Hsc70 (PubMed:10816573).  Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877).  Plays a role in protein transport into mitochondria via its role as co-chaperone.  Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510).  Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).
What are the official names of this protein?
DnaJ homolog subfamily A member 1, DnaJ protein homolog 2, HSDJ, Heat shock 40 kDa protein 4, Heat shock protein J2, HSJ-2, Human DnaJ protein 2, hDj-2.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor. Cytoplasm. Microsome. Nucleus. Cytoplasm, perinuclear region. Mitochondrion. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei.
Protein: LDH_STREI
Sequence: MTATKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLFNKAVGDAEDLSHALAFTSPKKIYAAKYEDCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTEVVKSGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANVAGVNLESYLKDVQNVEEAELVELFEGVRDAAYSIINKKGATFYGIAVALARITKAILNDENAVLPLSVFQEGQYANVTDCYIGQPAIVGAHGIVRPVNIPLNDAEQQKMEASAKELKAIIDEAFSKEEFASACKN
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRUA_BRANA
Sequence: MARLSSLLSFSLALLTFLHGSTAQQFPNECQLDQLNALEPSHVLKAEAGRIEVWDHHAPQLRCSGVSFVRYIIESKGLYLPSFFSTARLSFVAKGEGLMGRVVLCAETFQDSSVFQPSGGSPFGEGQGQGQQGQGQGHQGQGQGQQGQQGQQGQQSQGQGFRDMHQKVEHIRTGDTIATHPGVAQWFYNDGNQPLVIVSVLDLASHQNQLDRNPRPFYLAGNNPQGQVWIEGREQQPQKNILNGFTPEVLAKAFKIDVRTAQQLQNQQDNRGNIIRVQGPFSVIRPPLRSQRPQEEVNGLEETICSARCTDNLDDPSNADVYKPQLGYISTLNSYDLPILRFLRLSALRGSIRQNAMVLPQWNANANAVLYVTDGEAHVQVVNDNGDRVFDGQVSQGQLLSIPQGFSVVKRATSEQFRWIEFKTNANAQINTLAGRTSVLRGLPLEVISNGYQISLEEARRVKFNTIETTLTHSSGPASYGGPRKADA
What is the function of this protein?
This is a seed storage protein.
What are the official names of this protein?
Cruciferin, 11S globulin, 12S storage protein.
What is the protein family that this protein belongs to?
Belongs to the 11S seed storage protein (globulins) family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum.
Protein: RT03_ARATH
Sequence: MARKGNPISVRLGKNRSSDSSWFSEYYYGKFVYQDVNLRSYFGSIRPPTRLTFGFRLGRCIILHFPKRTFIHFFLPRRPRRLKRREKTRPGKEKGRWWTTFGKAGPIECLHSSDDTEEERNEVRGRGARKRVESIRLDDRKKQNEIRGWPKKKQRYGYHDRLPSIKKNLSKLLRISGAFKHPKYAGVVNDIAFLIENDDSFKKTKLFKLFFQNKSRSDGPTSYLRTLPAVRPSLNFLVMQYFFNTKNQINFDPVVVLNHFVAPGAAEPSTMGRANAQGRSLQKRIRSRIAFFVESLTSEKKCLAEAKNRLTHFIRLANDLRFAGTTKTTISLFPFFGATFFFLRDGVGVYNNLDAREQLLNQLRVKCWNLVGKDKIMELIEKLKNLGGIEELIKVIDMMIEIILRKRGIPYRYNSYFYEVKKMRSFLSNRTNTKTLIESVKIKSVYQSASLIAQDISFQLKNKRRSFHSIFAKIVKEIPKGVEGIRICFSGRLKDAAEKAQTKCYKHRKTSCNVFNHKIDYAPVEVFTRYGILGVKVWISYSQKKGRRAISETYEI
What are the official names of this protein?
Ribosomal protein S3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TAGPE_AGRFC
Sequence: MTAILENLAAARRAGKPAGITSVCSAHPVVLRAAIRRAAASQTAVLIEATCNQVNHLGGYTGMTPRDFVAFVNSIAAEEGLPAELLIFGGDHLGPNPWRREKAEDALTKAAAMVDAYVTAGFRKIHLDASMGCAGEPAALDDVTIAHRAAKLTAVAEKAATEAGLPKPLYILGTEVPVPGGADHVLETVAPTEPQAARNTIDLHREIFAQHGLSDAFERVIAFVVQPGVEFGSDNVVAYDPQAAQSLSAVLDGEPRLVFEAHSTDYQTEPALAALVRDGYPILKVGPGLTFAYREALYALDMIASEMVGTYGDRPLARTMEKLMLSAPGDWQGHYHGDDITLRLQRHYSYSDRIRYYWTRPEALAAVSTLHKALDGKTIPETLLRQYLGELPLAAVAGKEPEEVLVAAVDQVLATYHAATGEGRH
What is the function of this protein?
Involved in galactitol and D-altritol catabolism.  Catalyzes the epimerization of D-tagatose 6-phosphate to D-fructose 6-phosphate.
What are the official names of this protein?
D-tagatose 6-phosphate 4-epimerase.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family.
Protein: OSTCN_GORGO
Sequence: MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGPV
What is the function of this protein?
Constitutes 1-2% of the total bone protein.  It binds strongly to apatite and calcium.
What are the official names of this protein?
Osteocalcin, Bone Gla protein, BGP, Gamma-carboxyglutamic acid-containing protein.
What is the protein family that this protein belongs to?
Belongs to the osteocalcin/matrix Gla protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: TSHB_ANGAN
Sequence: MRVVLLASAVLCLLAGQVLSICSPVDYTLYVEKPECDFCVAINTTICMGFCYSLDPNVVGPAVKRLVVQRGCTYQAVEYRTAELPGCPPHVDPRFSYPVALHCTCRACDPARDECTHRASADGDRCSKPLLLHMHAYPGQSNYIQTL
What is the function of this protein?
Indispensable for the control of thyroid structure and metabolism.  May play some role in the biological processes of the immature fishes.
What are the official names of this protein?
Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, TSH-B, TSH-beta, Thyrotropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: CUZD1_RAT
Sequence: MEVTGRLFIWAILAVSCRAQLNSTAAEGRPRCTASLGGANLGETHKALILNLNADENCTWTIERPENRSIRIIFSHIQLDPDSRCENESIKVFDGRSTSGPLLGEACSKNDFVPVFESSANSLTFQIVTDWTRVQRSVFIFYYFFSSGTTIPNCGGYLQTLEGSFSSPNYPRPHPELAYCVWHIQVEKGYKINLNFTELFLEMDEYCRFDFIAVYDGPSTTSGLLKQVCGRGTPTFESSSDAMTVVLSTDYANSYRGFFASYASTYVQEVNTHSLSCASDKMRVIISKSYLQSLNYHESNLQLNDPTCRPSVSNVVEFSIPLHECGTIKKIEDHTISYTNIITFTQSPESAVITRKRHLQIVVTCEMEYNSTVEILYITEDDVIQNQSVLGKYNTSMALYESGSFENLIQESPYYVDLNQTLFVQATLHTSDPSLVVFLDTCRASPTSDFASPTYDLISSGCSRDETCEVYPLFGHYGRFQFNAFKFLRHLSSVYLKCKILICDTSDHTSRCNQGCVSRRKRDIPSYKWKTDSVIGPIRLKRDRLVNGDSGLLPQTHEAEISKQPLSHLHLFSFMVLALNVVIVVTATVRHFLNRWKDHGYQKLQVY
What is the function of this protein?
Localized to zymogen granules, where it functions in trypsinogen activation (By similarity).  May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity).
What are the official names of this protein?
CUB and zona pellucida-like domain-containing protein 1, CUB and ZP domain-containing protein 1, Estrogen-regulated protein 1, Uterus/ovary-specific protein 44.
What are the subcellular locations of this protein?
Zymogen granule membrane; Single-pass type I membrane protein.
Protein: MRAY_SHIDS
Sequence: MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLVGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDHJ_EUCGG
Sequence: MQGRLSAWLVKHGLVHRSLGFDYQGIETLQIKPEDWHSIAVILYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIEYGVDQPEEVCIKVFAPRRNPRIPSVFWIWKSADFQERESYDMLGICYDTHPRLKRILMPETWIGWPLRKDYIAPNFYEIQDAH
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: PCNA_MIMIV
Sequence: MSKKTGTKTSKSGSKKSNKDVEKLVDDEDIQDLSDKKNKISQSKNLVKNNKSSKNSKSSKSVKSTKTSTKTSLKKQVKTPPKKQTKTSSKKNKKDESDDDVTDNSDISDDDNTGNSDISDDENDQEEDNDISSDEEETETRQKSSGKKGNVNKDVGSSRKLKTDKNARNDNKVLEIRTTQTGALKQVFERVSGVISDCCLTFMPADKDINNAGDDNEYYEDESTKSSHKQSKTTDRPKNTGGIRIIRLTEDNNTLVKVVLEAANFEYFRCDEPKITVGVDMHTLHSHLKMINDDDPIVIYMKKDIQGSLYIRSLSENNDNSEEREIELFLMDIINPEIPVPKTEFQNRITMKSDKFHLICKHLSQNSTFVEITSINNEILFKGQSEGGKVTMTYKDTGYKKKEKPDQVIQGVYELRNLLGFSKCNKLCNTIEIYLKNDFPLVLVISVATLGKMYVFLSPIDNGN
What is the function of this protein?
Sliding clamp subunit.  Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (By similarity).
What are the official names of this protein?
Probable DNA polymerase sliding clamp, Proliferating cell nuclear antigen homolog, PCNA.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
Protein: OBG_RHOPS
Sequence: MKFLDEAKVYIRSGDGGNGCVAFRREKFIEFGGPNGGNGGRGGDVVVEAADGLNTLIDYRYQQHFKAQKGVNGMGSDRHGANGKDIVLKVPVGTQIIDEDKETLLHDFTKVGERFVLAEGGNGGFGNAHFKSSTNRAPRHANPGLPGEERWIWLRLKLIADAGLVGLPNAGKSTFLSKVSAAKPKIADYPFTTLHPQLGVVNSDGREFVLADIPGLIEGAHEGAGLGDRFLGHVERCRVLLHLIDATCEHAGKAYKTVRGELEAYADTLTDKIEIVALNKIDAVEPDELKKQKDRLKRAAKKTPLLISGVTGAGVPEALRALAAVIGEAPVSDKAIGTAQNAADAKPWAPQDV
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_ERYLH
Sequence: MTDPIPLHTPDRQPEDPDVALRPKSLAEFVGQAAAKDNLAVFIEAARSRGEAMDHTLFFGPPGLGKTTLAQIIARELGVGFRATSGPVIAKAGDLAALLTNLEPHDVLFIDEIHRLNPVVEEVLYPAMEDRALDLIIGEGPAARSVRIDLPPFTLIGATTRQGLLTTPLRDRFGIPVRLNFYTEEELEKVVTRGAGLMGLAIDAAGAREIARRSRGTPRVAGRLLRRVRDFAEVQKAGTVTSPIADAALTRLEVDGLGLDAMDRRYLTMIADIYKGGPVGVETLAAGLAEPRDTIEDVVEPYLIQLGLVARTARGRCLNDRGWEHLERQPPAGSQTGLFDGKS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SRBP1_PIG
Sequence: MDEPPFTEAALEQALAEPCELDAALLTDIEDMLQLINNQDSDFPGLFDAPYAGVAGGTDPTSPDASSPGSPTPPPSTMSSPLEGFLGGARTPPPPPVSPTQPAPTPLKMYPSVPAFSPGPGIKEEPVPLTILQPPTPQPLSGALLPQSLPALAPPQLSPAPVLGYPSPPGSFSSATPPGSTSQTLPGLPLASLPGVLPVSVHTQVQSAAPQQLLTATATPVVSPGTTTVTSQIQQVPVLLQPHFIKADSLLLTTMKTDMGTPVKAAGIGSLAPGTAVQAAPLQTLVSGGTILATVPLVVDTDKLPINRLAAGGKALSSGQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQQSNQKLKQENLSLRTAAHKSKSLKDLVSCSSGGRTDVPMEGVKPEVVDTLSPPPSDAGSPSQSSPLSLGSRGSSSGGSGSDSEPDSPVFEDSQMKPEQLPAPHGRGMLDRSRLALCVLVFLCLSCNPLASLMGSWALPGPSDATSAYHGPWRSVLGAEGRDGPGWVLWLLPPLVWLTNGLLVLLFLALLFVYGEPVTRPHSDPAVRFWRHRKQADLDLARGDFAQAAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLRRDSALEADTRTSACDAALVYHKLHQLHTMGKYPGGHLDAANLALSALNLAECAGDALSVAVLAEVYVAAALRVKTSLPRALHFLTRFFLSSARQACLAQSGSVPVAMQWLCHPVGHRFFVDGDWAVCGAPRDSLYSVAGNPVDPLAQVTQLFREHLLEQALHCVAQPSPGPGSADGDREFSEALGFLQLLNSCCDTAGAPACSFSIASSTAATAGTDPVAKWWASLTAVVTHWLGRDEEAAERLYPLVEHLPRALQESERPLPRAALHSFKAARALLGRGKAESGSASLAMCEKASGYLQDSLAATPAGSSIDKAMQLLLCDLLLVARTSLWQRQKPPPPSQASQGSSSGAQASALELRGFQRDLSGLRRLAQSFRPAMRRVFLHEATARLMAGASPARTHQLLDRSLRRRAGPCGRGGAAAAAAAELEPRPTRREQAEALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGGGTTVTSS
What is the function of this protein?
Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis.  Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3').  Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').  Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation.
What are the official names of this protein?
Sterol regulatory element-binding protein 1, SREBP-1, Adipocyte determination and differentiation-dependent factor 1, Sterol regulatory element-binding transcription factor 1.
What is the protein family that this protein belongs to?
Belongs to the SREBP family.
What are the subcellular locations of this protein?
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane; Multi- pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed. SUBCELLULAR LOCATION: [Processed sterol regulatory element-binding protein 1]: Nucleus.
Protein: CH602_RHOPA
Sequence: MSAKEVKFGVDARDRMLRGVDILANAVKVTLGPKGRNVVLDKSFGAPRITKDGVTVAKDIELDDKFENMGAQMVREVASKSADAAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVEAVVADLVKNSKKVTSNDEIAQVGTISANGDAEIGKFLADAMKKVGNEGVITVEEAKSLETELDVVEGMQFDRGYISPYFVTNADKMRVEFDDAYILINEKKLSNLNELLPLLEAVVQTGKPLVIVAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGQAISEDLGIKMENVTLQMLGRAKKVMIDKENTTIVNGAGKKADIEARVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDAMHATRAAVEEGIVPGGGVALLRASEQLKGLKTKNDDQKTGVEIVRRALSAPARQIAINAGEDGSVIVGKVLEKEQYAFGFDSQSGEYGDLVKKGIIDPTKVVRTAIQNAASVAALLITTEAMIAELPKKGGAGAGGMPPGGGMGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGA10_TOBAC
Sequence: MGFERAFVESSPEQENKLFVGVSYMDSSNKNQDPSESNNQISFGGQHQHHQQQFFYNHHQQQQLQNNNQVSFGMMQQSSSAIPGSLISKDSAGAYDLGELDQALFQYLDGQEPSSIQEQRQNSGMRPPTLNIFPSQPMHVEPSTTNKMNTGLVSPAISGSKRSSQPSMELSNNLKNNDAPSASGPEPPKAAKREGNRKGPTSSSEQDAPKTPDPKTLRRLAQNREAARKSRLRKKAYVQQLESSRIRLTQLEQELQRARAQGYYFGGNSLLGGEQNLPVNLANMSSDAAVFDMEYARWLEEHHRLMCELRNAVQEHFPENELRIYVDNCVTHYDEIMNLKSMLTKSDVFHLVSGMWKTPAERCFMWMGGFRPSELLKIILSQIEPLTEQQLMGICGLQQSTQEAEDALSQGLEALNHSLSDTIASDALSCPQNMANYMGQMALAMNKLSTLEGFVRQADNLRHQTIHRLHQLLTTRQAARCFLAIAEYFHRLRALSSLWHARPRQE
What is the function of this protein?
Transcription activator that binds to as1-like elements (5'-TGACGTAAgggaTGACGCA-3') in promoters of target genes.  Regulates transcription in response to plant signaling molecules salicylic acid (SA), methyl jasmonate (MJ) and auxin (2,4D) only in leaves.  Prevents lateral branching and may repress defense signaling.
What are the official names of this protein?
bZIP transcription factor TGA10, Protein TGACG (TGA) motif-binding protein 10.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL21_KORCO
Sequence: MGRRSFGFLYRSRDFLSKTPRERGRPSPAKLLKEFEVGDKVVIDVEPSIRRGMPHRRYQGKVGVVMGRRGEAYLVDIKLGGKTKHLIVLPVHLKKHSG
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: UDB15_RAT
Sequence: MSGKWISALLLLQISFCFKSGNCGKVLVWPMEYSHWMNIKIILEELVQKGHEVTVLRPSAFVFLDPKETSDLKFVTFPTSFSSHDLENFFTRFVNVWTYELPRDTCLSYFLYLQDTIDEYSDYCLTVCKEAVSNKQFMTKLQESKFDVVFSDAIGPCGELIAELLQIPFLYSLRFSPGYTIEQYIGGVLFPPSYVPMIFSGLAGQMTFIERVHNMICMLYFDFWFQTFREKKWDPFYSKTLGRPTTLAEIMGKAEMWLIRSYWDLEFPHPISPNVDYIGGLHCKPAKPLPKDIEDFVQSSGEHGVVVFSLGSMVRNMTEEKANIIAWALAQIPQKVLWRFDGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVTHGGANGIYEAIHHGIPMIGIPLFAEQHDNIAHMVAKGAAVEVNFRTMSKSDLLNALEEVIDNPFYKKNAMWLSTIHHDQPTKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIGFLLSCVAVTVVLALKCFLFVYRFFVKKEKKTKNE
What is the function of this protein?
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:7574722).  Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:7574722).  Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:7574722).  Displays glucuronidation activity toward several classes of xenoblotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed:7574722).  Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (PubMed:7574722).
What are the official names of this protein?
UDP-glucuronosyltransferase 2B15, UDPGT 2B15, UGT2B15, UDP-glucuronosyltransferase 2B36, UDPGT 2B36.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MRGB3_MOUSE
Sequence: MALRTSLITTTAPDKTSLPISICIIKFQVMNLLSITISPVGMVLNIIVLWFLGFQICRNAFSAYILNLAVADFLFLCSHSIFSFLIVCKLHYFLFYIRQLLDTVTMFAYVFGLSITTIISIECCLSIMWPIWYHCQRPRHTSAVICVLLWALSLLFPALQMEKCSVLFNTFEYSWCGIINIISGAWLVVLFVVLCGFSLILLLRISCGSQQIPVTRLNVTIALRVLLLLIFGIPFGIFWIVDKWNEENFFVRACGFSHHILYVYCINICVNATIYFLVGSIRHGKFQKMTLKLILQRAIQGTPEEEGGERGP
What is the function of this protein?
Orphan receptor.  Probably involved in the function of nociceptive neurons.  May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
What are the official names of this protein?
Mas-related G-protein coupled receptor member B3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.