PharMolix/UniProtQA huggingface dataset:
Protein: SYY2_BACLD
Sequence: MQQQQFDQLTTAEKREVERQLHLYMDGAEEVIPPEELRAKLAKSILTGEPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKSAARKQLTDEEVRRNAETYFQQFGKVLDQNKVELHYNSKWLKRLTLEDVIELAGKITVARLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLDSDIELGGTDQHFNVLMGRHFQEKYGKEKQVVILMPLLEGLDGIEKMSKSKNNYIGIDEDPHEMFGKTMSLPDSLMKKYIHLATDLEAEEKKRLVKDLETGAVHPRDAKMLLGKTIVNMYHGSKAAEAAEQQFKKVFQQNSAPDNITAVHWQGGGTVPVTDLLVTLELLPSKSEARRMIQNGGVKINGAKAESIHADIALEHGMIIQVGKRKFVKLQMHQ
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase 2, Tyrosyl-tRNA synthetase 2, TyrRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_HAEIN
Sequence: MSRVCQVTGKRPAVGNNRSHAMNATRRRFLPNLHTHRFWVESENRFVTLRLTAKGMRIIDKKGIDAVLAEIRARGEKI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: MET_SHEEP
Sequence: MKAPAVLAPGILVLLFTFVQKSNGECKEALVKSRMNVNMQYQLPNFTAETSIRNVVLHKHHIYLGAINYIYVLNDKDLQKVAEYKTGPVLEHPDCFPCQDCSHKANLSGGVWKDNINMALLVDTYYDDQLISCGSVHRGTCQRHVLPPNNTADIESEVHCMYSPQEDEETNQCPDCVVSALGTKVLLSEKERFINFFVGNTINSSYFPDHSLHSISVRRLKETQDGFKFLTDQSYIDVLPELQDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSADSGLHSYMEMPLECILTEKRRKRSTKQEVFNILQAAYVSKPGAQLARQIGANLNDDILYGVFAQSKPDSSEPMNRSAVCAFPVKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRNDEYRTEFTTALPRIDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGSLTPHVNFPLDSHPVSPEVVVEHPLNQNGYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPSFVQCGWCHDKCVRLEECPSGRWTQETCLPTIYKVFPTSAPLEGGTTLTVCGWDFGFKRNNKFDLKKTRVLLGNESCTLTLSESTTNMLKCTVGPATNEHFNMSIVISNSRGSVQYSMFSYVDPIITSISPNYGPKTGGTLLTLTGKHLNSGNSRHISIGGKTCTLKSVSYSILECYTPAQSAPTEFSVKLKIDLANREVNSFIYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSIIRMVINVHEAGKNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGIHSKYFDLIYVHNPVFKPFEKPVMISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIQSHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIVGVVSVSIILLLLLGLFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMEYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAELRPSFSELVSRIAAIFSAFIGEHYVHVNATYVNVRCVAPYPSLLSSQENVSGEDDDDT
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.  Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.  Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.  Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.  During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation.  In adults, participates in wound healing as well as organ regeneration and tissue remodeling.  Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
What are the official names of this protein?
Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: Y3667_AERHH
Sequence: MLIVVSPAKTLDYESPLVTSRFTQPELLDHSAELIGRARQLSPDQIASLMKISDKLAGLNAARFADWQPDFSPANARQALLAFKGDVYTGLAVEDFSEADLDFAQAHLRMLSGLYGVLRPLDLMMPYRLEMGIRLDNGRGKDLYQFWGDIITAHLNKALAAQGDEVLINLASDEYFKSVRPKALQGRIITPVFKDEKNGQFKIISFYAKKARGMMARHIIKHRLTKVEQLTGFNADGYYFVAEESDANTLMFKRAEN
What are the official names of this protein?
UPF0246 protein AHA_3667.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: DPP4_TRIVH
Sequence: MKTSQFLSLLLLAGIAQAIVPPREPRPPTGGGNKLLTYKECVPRATISPRSTSLAWINSDEDGQYISQSDDGALILQNIVTNTNKTLVAADKVPKGYYDYWFKPDLSAVLWATNYTKQYRHSYFANYFILDIEKGSLTPLAQDQAGDIQYAQWSPMDNSIAYVRGNDLYIWNNGKTKRITENGGPDIFNGVPDWVYEEEIFGDRFALWFSPDGEYLAYLRFNETGVPTYTIPYYKNKQKIAPAYPRELEIRYPKVSAKNPTVQFHLLNIASSQETTIPVTAFPENDLVIGEVAWLSSGHDSVAYRAFNRVQDREKIVSVKVESKESKVIRERDGTDGWIDNLLSMSYIGDVNGKEYYVDISDASGWAHIYLYPVDGGKEIALTTGEWEVVAILKVDTMKKLIYFTSTKYHSTTRHVYSVSYDTKVMTPLVNDKEAAYYTASFSAKGGYYILSYQGPNVPYQELYSTKDSKKPLKTITSNDALLEKLKEYKLPKVSFFEIKLPSGETLNVKQRLPPNFNPHKKYPVLFTPYGGPGAQEVSQAWNSLDFKSYITSDPELEYVTWTVDNRGTGYKGRKFRSAVAKRLGFLEPQDQVFAAKELLKNRWADKDHIGIWGWSYGGFLTAKTLETDSGVFTFGISTAPVSDFRLYDSMYTERYMKTVELNADGCDDNVHFQNAAVLSNTLMNGGVTADKLTTQWFTDSDHGIRYDMDSTYQYKQLAKMVYDQKQRRPERPPMHQWSKRVLAALFGERAEE
What is the function of this protein?
Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.  Contributes to pathogenicity (By similarity).
What are the official names of this protein?
Probable dipeptidyl peptidase 4, Dipeptidyl peptidase IV, DPP IV, DppIV.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Secreted.
Protein: MCR1_YEAS7
Sequence: MFSRLSRSHSKALPIALGTVAIAAATAFYFANRNQHSFVFNESNKVFKGDDKWIDLPISKIEEESHDTRRFTFKLPTEDSEMGLVLASALFAKFVTPKGSNVVRPYTPVSDLSQKGHFQLVVKHYEGGKMTSHLFGLKPNDTVSFKGPIMKWKWQPNQFKSITLLGAGTGINPLYQLAHHIVENPNDKTKVNLLYGNKTPQDILLRKELDALKEKYPDKFNVTYFVDDKQDDQDFDGEIGFISKDFIQEHVPGPKESTHLFVCGPPPFMNAYSGEKKSPKDQGELIGILNNLGYSKDQVFKF
What is the function of this protein?
The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria.  Involved in the reduction of D-erythroascorbyl free radicals (By similarity).
What are the official names of this protein?
NADH-cytochrome b5 reductase 2, Mitochondrial cytochrome b reductase, p34/p32.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
[NADH-cytochrome b5 reductase p32 form]: Mitochondrion intermembrane space. SUBCELLULAR LOCATION: [NADH-cytochrome b5 reductase p34 form]: Mitochondrion outer membrane; Single-pass membrane protein.
Protein: IMDH_ASPFU
Sequence: MPIANGDSLGCAMKADIQDYTKALEILEKEYTTRDGLDVDTLLDSDKHGALTYNDFLILPGYIGFPASDVTLDTPVTKRVSLKVPLLSSPMDTVTEHNMAIHMALLGGLGVIHHNCSPEDQAEMVRKVKRYENGFILDPVVLSPKATVGEAKALKAKWGFGGFPVTENGTLRSKLVGMVTSRDIQFHTNLDDPVTAIMSTDLVTAPAGTTLAEANDVLRSSKKGKLPIVDADGNLVSLLSRSDLMKNLHYPLASKLPDSKQLICAAAIGTREEDKHRLKLLVEAGLDIVVLDSSQGNSIYQIEMIKWVKKTFPEIDVIAGNVVTREQAAALIAAGADGLRIGMGSGSACITQEVMAVGRPQAVAVRSVASFAARFGVPCIADGGIQNVGHIVKGLAMGASTVMMGGLLAGTTESPGEYFVSNEGQLVKAYRGMGSIAAMEDKKAGAGSKDSKASNAGTARYFSEKDRVLVAQGVAGSVLDRGSVTKFVPYLVAGVQHSLQDIGVKSLDELHDGVNKGIVRFEMRSASAMAEGNVHGLHSYDKKLYS
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDPX_ECOLI
Sequence: MSDTTELVDLAVIFPDLEIELKYACADNITGKAIYQQARCLLHKDAITALAKSISIAQLSGLQLVIYDAYRPQQAQAMLWQACPDPQYVVDVTVGSNHSRGTAIDLTLRDEHGNILDMGAGFDEMHERSHAYHPSVPPAAQRNRLLLNAIMTGGGFVGISSEWWHFELPQAASYPLLADQFSCFISPGTQHVS
What is the function of this protein?
Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.  May have a role in cell-wall turnover.
What are the official names of this protein?
D-alanyl-D-alanine dipeptidase, D-Ala-D-Ala dipeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M15D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYPA_GEOSM
Sequence: MHEMSITQSVVEICEVHAAGRKVTEVVLLIGELSGVVPESVEFCFEACSKGTLLEGARLQLELVLGVGSCPACHGEFPISTLFEPCPGCGAFGLSVVAGEELRVKELELE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: Y1218_STAHJ
Sequence: MKLSFHGQSTIYFEGNGKKVIVDPFISGNDKCDLDEQTLDVDYIILTHGHADHFGDVVELANRNHATVIGSAELQGYLSTYHGVEDVHGMNIGGKAKFDFGSVKYVQAFHSSSFTHEDGIPVYLGMPMGLILEVEGKTIYHMGDTGLFSDMKLIAERHPVDVCFVPIGDNFTMGIDDASYAINEFVKPKISVPVHYNTFPLIEQDPQQFKDAVHEGEVQILEPGESVSF
What are the official names of this protein?
UPF0173 metal-dependent hydrolase SH1218.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: SYS_MYCLE
Sequence: MIDLQLLREDPDVVRRSQLSRGEDPALVDALLTADTARRAAISAADSLRAEQKATSKSLGAASAEDRPALLERAKDLAEQVKAAETTQAETAAAFAAAYMAISNVVLDGVPTGGKDDYAVLDIVGDPPPLSNPKDHLELGEALGLIDMQRGAKVSGSRFYFLTGRGALLQLGLLQLALRLAVENDFIPMIPPVLVRPEVMSGTGFLGAHAEEVYRVDDLYLVGTSEVPMAGYHSDEILDLSVGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCAPTDAEVEHQRLLGWQREMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWVPTQGSYCELTSTSNCTTFQARRLATRYRDASGKPQIVATLNGTLGTTRWLVAILENHQRPDGSVRVPPALVPFVGTELLESPR
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EBS1_ASHGO
Sequence: MTLTPMEDKGIIPNFNDFKRQLAELLQSRSTVEDITLLQGFLQLVHSKTQQWRGAEGLPATPDLLDAVWKEIHYPIFKWFQQWRAHLLEAAEGGPQERTYISFRRMNGKLNKIFKIIRQFYNGLVQQLFDRYDFGKLLPAGVIRELNVQSGGELQTLDDSSYFTILCVMSLQRCLLYLGCCHRYKCCCSKLSKRFHISDFDDSMRYFMLAKQIVPSVGETYLQEGLVYVQTGNYGHAAYAFMRGSLSRMPTDAGIPNLESIVADASSGLFAKHQGILKRLRSKESDSNKLINREVLEFYFLALFSSVYAPESWSKQGSDIRHCTEILFEKVRSRYARNVRLILQDVLLFIGGFDLVIKKAKAMGLNRSDTLPSNCTAFLETAFDFFSHVIDSVVLKEWQSFDTWEYLALVRVICVWIKSHSIVTQFAHRHTQFCQSVAHLLNNILAHTEYQQLMDVEHRPKRDYFFQEDIMLKDFSAIGHTLSDFNDVDLFQMENLPDRLAGLVDDKLTAKEEGLLKLHAIVFIGKKFLANNDVNIVWCDESKRFNSLKPDVPLRTCSPPKAKTPPPSTSDYTPAGAKQTKKSKPKRNSRRVQSLSSLEAKLMERKGLRQSVAEGRVYSGCSVPAAPMSFDVAPSAHLYQDRAAGTSATQEAATYYNQGYNGPMQLGSTEILNSRSPSGNNRIAFHPSHQAYMQMIQTPQPQAWPTAYGHNAYYSQPTQHPYPMSSQLAQFQNGPIPFVAGPYAMYMPPPGPGMVVLNNGHPMIPNESPPQQHYP
What is the function of this protein?
Involved in telomere maintenance.
What are the official names of this protein?
Protein EBS1.
What is the protein family that this protein belongs to?
Belongs to the EST1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: CYCF_CLITE
Sequence: GIPCGESCVFIPCISSVVGCSCKSKVCYLD
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide cter-F.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: GRM1_CAEEL
Sequence: MDKKWSLEQRWLHLLNQQFLDCLNHLFNHYRRLSTFQKPPSIIRHMFSVLALAIQILANVNVVAQTTEAVDLAPPPKVRQIRIPGDILIGGVFPVHSKSLNGDEPCGEIAETRGVHRVEAMLYALDQINSQNDFLRGYKLGALILDSCSNPAYALNQSLDFVRDMIGSSEASDYVCLDGSDPNLKKQSQKKNVAAVVGGSYSSVSVQLANLLRLFRIAQVSPASTNADLSDKNRFEYFARTVPSDDYQAMAMVEIAVKFKWSYVSLVYSADEYGELGADAFKKEARKKGICIALEERIQNKKESFTESINNLVQKLQPEKNVGATVVVLFVGTEYIPDILRYTAERMKLTSGAKKRIIWLASESWDRNNDKYTAGDNRLAAQGAIVLMLASQKVPSFEEYFMSLHPGTEAFERNKWLRELWQVKYKCEFDTPPGSTASRCEDIKQSTEGFNADDKVQFVIDAVYAIAHGLQSMKQAICPDDAIENHWISRYSKQPEICHAMQNIDGSDFYQNYLLKVNFTGKTISIFSSFRLSPFSDIVGKRFRFSPQGDGPASYTILTYKPKSMDKKRRMTDDESSPSDYVEIGHWSENNLTIYEKNLWWDPDHTPVSVCSLPCKIGFRKQLIKDEQCCWACSKCEDYEYLINETHCVGCEQGWWPTKDRKGCFDLSLSQLKYMRWRSMYSLVPTILAVFGIIATLFVIVVYVIYNETPVVKASGRELSYILLISMIMCYCMTFVLLSKPSAIVCAIKRTGIGFAFSCLYSAMFVKTNRIFRIFSTRSAQRPRFISPISQVVMTAMLAGVQLIGSLIWLSVVPPGWRHHYPTRDQVVLTCNVPDHHFLYSLAYDGFLIVLCTTYAVKTRKVPENFNETKFIGFSMYTTCVVWLSWIFFFFGTGSDFQIQTSSLCISISMSANVALACIFSPKLWIILFEKHKNVRKQEGESMLNKSSRSLGNCSSRLCANSIDEPNQYTALLTDSTRRRSSRKTSQPTSTSSAHDTFL
What is the function of this protein?
G-protein coupled receptor for glutamate.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (By similarity).
What are the official names of this protein?
Probable metabotropic glutamate receptor mgl-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL7A_METMA
Sequence: MAQLAKFDVPEELTNKALEALELARDTGKIKKGTNEATKAIERGNAKLVLIAEDIEPAEIVAHIGPLSEEKKAPYIYIKNQKDLGAASGLGVSCATVAIVDAGKAAEMIQDIAQKLDALK
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCN3_MOUSE
Sequence: MMWRWSFLLLLLLLRHWALGKPSPDAGPHGQDRVHHGTPLSEAPHDDAHGNFQYDHEAFLGRDVAKEFDKLSPEESQARLGRIVDRMDLAGDSDGWVSLAELRAWIAHTQQRHIRDSVSAAWHTYDTDRDGRVGWEELRNATYGHYEPGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVVAETLEDLDKNKDGYVQVEEYIADLYSEEPGEEEPAWVQTERQQFREFRDLNKDGRLDGSEVGYWVLPPSQDQPLVEANHLLHESDTDKDGRLSKAEILSNWNMFVGSQATNYGEDLTRHHDEL
What is the function of this protein?
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:26252542).  Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (PubMed:26252542).  By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (PubMed:26252542).  Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity).  This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity).
What are the official names of this protein?
Reticulocalbin-3.
What is the protein family that this protein belongs to?
Belongs to the CREC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: PEPQ_SALEP
Sequence: MESLAALYKNHIVTLQERTRDVLARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEEVEVVALPKADGIGSQLPAARGNIGYIGPVPERALQLDIAASNINPKGVIDYLHYYRAYKTDYELACMREAQKMAVSGHRAAEEAFRSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPSEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAHLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPSKYPYLRCTRVLQPRMVLTIEPGIYFIESLLAPWREGPFSKHFNWQKIEALKPFGGIRIEDNVVIHENGVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: RS12_CUTAK
Sequence: MPTIQQLVRKGRTDKISKNKTPALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLSSGIEVTAYIPGVGHNLQEHSMVLVRGGRVKDLPGVRYKIVRGSLDTQGVKGRKQARSRYGAKKEK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SPD2_CAEEL
Sequence: MEDDAPMNLCNEQFEEIEDSPIDDNDNESFYNADGDVELEEEEVHETPKNFKNGGRFKTNMTNPKVNDLTTIEEKNEDLRSAASSRSASRPASVMSDKSFSSQFEFQSGGENAIEEYTNQVFADENKADLLFPETSKFMNGASPPKDKHHSWEPSIHHYDKQPPPDIQTNSPVFGNLNHRKNKLIPQARAKPGANDNEIVERDNDENVPTTSDKSAFITSPMNSTNHDEKTSTPKRPTNRKIGQYQGPNFDLSSIYVGSPQHQNTSISTGQQMPTSSYSHAHSETMMTNQTINESMVRRVLNGNNKNQDLFAALEEARKRRAAQPSKPDFRINTTRTRVPIKPTSARHSGNVVSSTSNDNTTAASSKDLTTSRKAMETFRQNASMADATNSNTASMTSILSTISTARTDISRSSRNHGGGFSNTSVSTVIPANNGNVSLSHGRDGRDSVSSVRTMSRASSTSTVYAGSTFSGVSKPLRIHAKRVAFGCVAVGETLRVEVEVENISDRQCLVRASTDSTTPVYQILDNKLTMVDPKKSIKFQVSFSPSSVGRYQVIMSIEVPAQNFIHKIPMWGNGGIAKFVPTSPDLQQTINQSEYAMCTSCAKRISFKISNSAGTRDGFAMIKVFDSAMRQLPDGCVAFFPAPGFIVKKKSDKRVDIRIDSSYIDLHDENNFRTSSSLSTASTTSSFQRRILPGAKFFVHVVWGEETMRTRLRLLEVRTGQHQLIDGHDFTSFQFSDEEVLRAVPVGFPAIKPEDRDLFAASYRSFFINFFTSTTEFRAATSRKKKEICSNDDSTLLETTAFRNQTFVNDVTIVPNTRFSNRK
What is the function of this protein?
Required both for centrosome duplication and maturation (PubMed:15068791, PubMed:15186742, PubMed:19081077).  Required for pericentriolar material (PCM) recruitment (PubMed:15068791, PubMed:15186742).
What are the official names of this protein?
Spindle-defective protein 2.
Protein: COX5A_DROME
Sequence: MLSITARNLASALRSSLVGTSSRVAAVRCLHGTEESAEEFDKRYEKYFSREGIDGWEIRKGMNDLLGMDLVPSPKIIEAGLRASRRVNDIALAIRWLEGCKDKCGDQKATLYPYLLEKITPTLQELGIPTIEELGYDKPELALKSVYDA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 5A, mitochondrial, Cytochrome c oxidase polypeptide Va.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5A family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: Y268_AQUAE
Sequence: MIFSDTVRYALIALAYLALNRDRLVKVEEIAKVHKIPRPFLAKVMHELSKRGVVYSVKGPRGGFSLAKEPDKITIWDIIELFGDAYKYEMCLLMPHKCSEFADNPCIVHHKWEELKSQIQDFFKGTTIKDLINIEEKHLFPVSR
What are the official names of this protein?
Putative HTH-type transcriptional regulator aq_268.
Protein: HIS4_CORJK
Sequence: MASTDNSRALTLLPAVDVADGQAVRLVQGAAGTETSYGAPIEAALAWQNAGAEWIHLVDLDAAFGRGSNFELLKEVTGQLDVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWCESVISRYGDKVAIGLDTREVDGEWRLRGRGWTSDGGELWEVLERLDSQGVSRLVVTDVSRDGMLNGPNIDLLREVAAATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKFTLEEALEAAQGVARGSDI
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_METCA
Sequence: MKVRASVKRICRNCKVLKRNGIVRIICKDARHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: ILVC_STRSV
Sequence: MAVTMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDTGHDVIIGVRPGKSFDKAKEDGFDTYTVAEAAKLADVIMILAPDEIQQDLYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKDIAMDWCKGVGSARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVDDYKAGRPKLTAYREQAANLEIEKVGAELRKAMPFVGKNDDDAFKIYN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.