PharMolix/UniProtQA huggingface dataset:
Protein: RLMN_FRATF
Sequence: MQQDKVNLLGLNQKAIEDFFISIGKKKFHARQVFKWIHKKGVIDFDAMTDLGKNLRHKLKDKAQITIPKVVFSKASKDGTHKWLIDVGGSAVETVFIPEEGRGTLCVSSQIGCTLNCSFCSTGKQGFNRNLSAAEVIAQLWIAARTLSKTDGEHDFTVTNIVMMGMGEPLMNFENVVPAMDIMMDDLAYGLSRRKVTLSTSGVVPRIYDLLEQSGVSLAVSLHTPNDMLRNEIVPINKKYNIDELLEACKLYAQKGPHKHITFEYTLMEEVNDNLSDAEELVALLKSREVPAKINLIPFNPYPGTPYKKPSNNRIHRFKEFLQHNGFVTTVRKTRGDDIDAACGQLAGDVMDKTNRKQIYLKKLGDTNAN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_VEREI
Sequence: MTTIRVKENEPFDVALRRFKRTIEKLGLLTDLRAREFYEKPTAERKRKKAAAVKRHYKRVRSMQLPKKMY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: DEOD_PECAS
Sequence: MATPHINAEMGDFADVVLMPGDPLRAKFIAETFLDDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITEFGVKKIIRVGSCGAVREDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFDMVRNAVDAAKARDVSVRVGNIFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALAICTVSDHIRTGAQTTSEERQTTFNEMIEIALESVLLGDNE
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: HIS4_BIFLO
Sequence: MSLTLLPAVDVRDGKAVRLRQGESGSETDYGSPFEAARTWVEAGAEWIHLVDLDAAFGTGNNRDQLREIVHELGDRVNIELSGGVRDDASLDAALEAGAARVNIGTAALENPDWTASVIKKYGDRVAVGLDVRGHTLAARGWTREGGDLFETMKFLDSVGCSRYVVTDVAKDGMMSGPNIQLLSEVAERTDAKVTASGGISKLDDLRAIKELAEIGVDSAILGKSLYARAFTLQEALEVAK
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTDA_METLZ
Sequence: MIIDILNSDSDPAGRNIRAAIDELLKNPPEGGFPLFDGNEVTFHTVSGRIIHAEKSAVNPDADLIIVVSRHSSVNPVPVLTVHPAGNFGIAGLGGNDRELGLTSPAWMKSILQNHAEFVPEGYRVSYEITHHGPTDFPVPFFFVEVGSTEKEWNDPAACIAAAKSVLYARPSPEIVPLIGFGGTHYAVRQTAIGLETKGAFGHMMHTRDVGSVSKEMVSQMIAKSCGVFAAHIDRKALSKQEISHIEGILAEVGLEEITEGDLRKMNAMSFSTWVAYRDLAALQAPGLKIFPHGRIFDGDPAVVELPSDLFSAAFLGYEEIFLAELDKMGNIFHTTGKGGRLMPTLLTSAKNRQKVSGDLIVLSVQQITRTQDSLVEGDQITIARRQFDPVLARTLGVPSGPLYGQLVAGKPVTLPDGRMITPDMVTKVVRTSIKIPGLENYS
What is the function of this protein?
D-aminoacyl-tRNA deacylase with broad substrate specificity.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, D-tyrosyl-tRNA(Tyr) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DtdA deacylase family.
Protein: H13A8_CYRHA
Sequence: MKTAIFTVVLALAVFAVLSFGWEANEKALSEEFTELIHEKGAASETEARECRYFWGECHDHMPCCDWLVCRYKWPITYNICVWNRTFPEK
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U7-theraphotoxin-Hhn1a 8, U7-TRTX-Hhn1a, Hainantoxin-XIII.8, HNTX-XIII.8.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 13 (Hntx-13) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_LISMC
Sequence: MALTQERKNEIIAEYRVHDTDTGSPEVQIAVLTAEINSLNEHVRVHKKDHHSYRGLMKMVGHRRNLLTYLRKKDVQRYRELIKRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: NAMA_BACAH
Sequence: MNSELFSPYTIKDVTLKNRIVMSPMCMYSSENEDGQVTNFHLIHYGTRAAGQVGLVMIEATAVLPEGRISNKDLGIWDDSLIEGLHKTTTFIHDNGAKAAIQLAHAGRKAELETDALAPSAVPFNETMKIPVEMSIQQIKNTILAFQQAAVRSKQAGFDVIEIHGAHGYLINEFLSPLSNKRTDEYGGSPEKRYRFLREIIDSINEVWNGPLFVRISANDYHPDGLTVQDYVQYTKWMKEQGVDLIDCSSGAVVPARIDVYPGYQVQYAKHIKEHANIATGAVGLITTGAQAEQILTNNEADLIFIGRELLRNPYFPRIAANELGFELEEPYQYERAPGKISTNK
What is the function of this protein?
Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones.  It also reduces the nitro group of nitroester and nitroaromatic compounds.  It could have a role in detoxification processes.
What are the official names of this protein?
NADPH dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.
Protein: ALBU_CANLF
Sequence: MKWVTFISLFFLFSSAYSRGLVRREAYKSEIAHRYNDLGEEHFRGLVLVAFSQYLQQCPFEDHVKLAKEVTEFAKACAAEESGANCDKSLHTLFGDKLCTVASLRDKYGDMADCCEKQEPDRNECFLAHKDDNPGFPPLVAPEPDALCAAFQDNEQLFLGKYLYEIARRHPYFYAPELLYYAQQYKGVFAECCQAADKAACLGPKIEALREKVLLSSAKERFKCASLQKFGDRAFKAWSVARLSQRFPKADFAEISKVVTDLTKVHKECCHGDLLECADDRADLAKYMCENQDSISTKLKECCDKPVLEKSQCLAEVERDELPGDLPSLAADFVEDKEVCKNYQEAKDVFLGTFLYEYARRHPEYSVSLLLRLAKEYEATLEKCCATDDPPTCYAKVLDEFKPLVDEPQNLVKTNCELFEKLGEYGFQNALLVRYTKKAPQVSTPTLVEVSRKLGKVGTKCCKKPESERMSCAEDFLSVVLNRLCVLHEKTPVSERVTKCCSESLVNRRPCFSGLEVDETYVPKEFNAETFTFHADLCTLPEAEKQVKKQTALVELLKHKPKATDEQLKTVMGDFGAFVEKCCAAENKEGCFSEEGPKLVAAAQAALV
What is the function of this protein?
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs.  Its main function is the regulation of the colloidal osmotic pressure of blood.  Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity).  Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).  Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity).  The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity).  The rank order of affinity is zinc > calcium > magnesium (By similarity).  Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E. coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E. coli (By similarity).  Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
What are the official names of this protein?
Albumin.
What is the protein family that this protein belongs to?
Belongs to the ALB/AFP/VDB family.
What are the subcellular locations of this protein?
Secreted.
Protein: ERG_HUMAN
Sequence: MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY
What is the function of this protein?
Transcriptional regulator.  May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
What are the official names of this protein?
Transcriptional regulator ERG, Transforming protein ERG.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: TBX6_HUMAN
Sequence: MYHPRELYPSLGAGYRLGPAQPGADSSFPPALAEGYRYPELDTPKLDCFLSGMEAAPRTLAAHPPLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPETTFISVTAYQNPQITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPAATEAYGSGDTPGGPCDSTLGGDIRESDPEQAPAPGEATAAPAPLCGGPSAEAYLLHPAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAPHFLQGGPFPLPYTAPGGYLDVGSKPMY
What is the function of this protein?
T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal.  Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development.  Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).
What are the official names of this protein?
T-box transcription factor TBX6, T-box protein 6.
What are the subcellular locations of this protein?
Nucleus.
Protein: ADD_ECOLU
Sequence: MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVREGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVAELAAHPLKTFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: LEU3_RALSO
Sequence: MTKIAVLPGDGIGTEIVAEAVKVLKTLGETFEMETAPVGGAGYEAKGHPLPEDTLKLAKEADAILFGAVGDWKYDTLPRELRPEQAILGLRKHLQLFANFRPAICYPELAGASSMKPEIVAGLDILIVRELTGDIYFGQPRGVRAAPDGLFAGAREGFDTMRYSEPEIRRIAHVAFQAAAKRGKKLCSVDKANVLETFQFWKDIVTDVHKEYPEVELSHMYVDNAAMQLVKAPKNFDVVVTGNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLATILSAAMMLRYTLGKAEQADRIENAVKKVLAQGYRTGDILTPGCKQVGTVEMGDAVVAAL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECFA2_BACHK
Sequence: MEITFQKVEHRYQYKTPFERRALYDVDVSFPSGGYYAIIGHTGSGKSTMIQHLNGLLQPTNGTVQIGEHFISAGKKEKKLKPLRKKVGVVFQFPEHQLFEETVEKDICFGPTNFGVSEEAAKQKAREAIELVGLEPELLARSPFELSGGQMRRVAIAGVLAMEPEVLVLDEPTAGLDPKGQNELMEMFYKLHKEKGLTVILVTHNMEDAAKYAEQIVVMHKGTVFLQGSAEEVFSHADELEKIGVDLPMSLKYKRAIEEKFGISIPKATLSLEDLTHEVVQVLRKGGHESCSS
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CSPA_SHIBO
Sequence: DKGFGFITPDDGSKDVFVHFSAIQNDGYKSLDEGQKVSFTIESGAK
What are the official names of this protein?
Major cold shock protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_RHOP2
Sequence: MPQTIYVLNGPNLNLLGTREPAIYGHATLADVERLCTETAASCGLSAVCRQSNHEGELIDWIHQARDEQAVGIVLNAGGYTHTSVALHDALVGVQIPAVEVHVSNVFARDSFRHHSFIAKAAFASLCGFGIDGYRLAILGLAAKIGTSAKA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RL6_CHLMU
Sequence: MSRKARDPIVLPQGVEVSIQNDEISVKGPKGSLTQVLAKEVEIAVKGNEVFVSPAAHIIDRPGRMQGLYWALIANMVKGVHLGFEKRLEMIGVGFRASVQGSFLDLSIGVSHPTKMPIPTGLEVSVEKNTLISIKGINKQLVGEFAACVRAKRPPEPYKGKGIRYENEYVRRKAGKAAKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: CSRA_PSYIN
Sequence: MLILTRRVGETLMIGDNVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYMRIQAEKSGE
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IAN3_ARATH
Sequence: MNHSEQASAYKAVKNIVLVGRTGNGKSATGNSLIGKDVFVSEAKATGVTKTCQTYKAVTPGGSRINVIDTPGLFDLSVSAEFISKEIINCLRLAEGGLHVVVLVLSVRTRITQEEENTLSTLQVLFGNEILDYLIVLFTGGDELEANNQTLDDYFHQGCPYFLKTVLGLCDDRKVMFNNMTKDKHKKVEQVQQFLALVAKVEERNEGKPFRGKMYLEIKEETEWLKKQKKAVEASNLGEAELAKMKKELQMEHDTRMSQMEDMVKNMLKETSAAHERMVSMLNENLENAHRENIDLRKAHDHEQKKRMMIQLGLGVPGALGMIAPAALAMCSIL
What are the official names of this protein?
Immune-associated nucleotide-binding protein 3, AtIAN3, AIG1-like protein.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
Protein: NDK_THEVB
Sequence: MERTFLAIKPDGVQRGLVGTIIQRFEQKGYTLVGLKLMRVSRELAEQHYGEHKDKPFFPGLVNFITSGPVVAMVWEGRGVIANARKLIGATNPLNAEPGTLRGDFAVDVGRNVIHGSDSPENAEREINLWFQTQELVPWEPALTSWVYEM
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2A01_ARATH
Sequence: MSKKHCSELLPNKMFRNQDSKYLIPVQKEAPPVTTLPMKASTVKSPHNCEAILRDADPPISLSSVNLSEQLRSGVFLKPKKQIKYWVDERNSNCFMLFAKNLSITWSDDVNYWTWFTEKESPNENVEAVGLKNVCWLDITGKFDTRNLTPGIVYEVVFKVKLEDPAYGWDTPVNLKLVLPNGKEKPQEKKVSLRELPRYKWVDVRVGEFVPEKSAAGEITFSMYEHAAGVWKKGLSLKGVAIRPKQ
What are the official names of this protein?
Protein PHLOEM PROTEIN 2-LIKE A1, AtPP2-A1.
Protein: SP2AB_BACCR
Sequence: MRNEMNLQFSALSQNESFARVHRAAFIAQLDPTMEELTEIKTVVSEAVTNAIIHGYEGNAEGIVYISVILEEAMVKLTIRDEGIGIFNLDEARQPLFTTKPELERSGMGFTIMENFMDEVEVISNESFGTTIHLTKYLSNSNALCN
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: MNHB2_STAES
Sequence: MKENDVVLKSVTKIVVFILLTFGFYVFFAGHNNPGGGFIGGLIFSSAFILMFLAFDVNEVLKSLPIDFKKLMIIGSLISVATASVPMFFGKPFLYQTEANVTFPLLGHVHVTTVTLFELGILLTVVGVIVTVMLSISGGRS
What are the official names of this protein?
Putative antiporter subunit mnhB2, Mrp complex subunit B2, Putative NADH-ubiquinone oxidoreductase subunit mnhB2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNLJ_RICM5
Sequence: MQNIDLISEKEAQKLLEELADKIAAYNHAYYIEDNPLVSDSEYDQLFNTNLKLEQKFPHLILENSPSKKVGAKIANKFAKVTHQVPMLSLSNAFDEQDVRDFVDRIKNFLRLNEFAPIFCEPKIDGLSFSAVYKNGVLTTGATRGDGYVGEDITANIKTIKNFPHKIDNVPEFLEVRGEIYIEKQDFLNLNKEQEEQGKDKFANPRNAAAGSLRQLDASITAKRPLKYFVYSGGVTEQNLASSQDQLLTKLKECGFNINEISKLASSEEEIFAFYEYLKTNREDLPYEIDGVVYKLNDFALQNRMGFIARSPRFATAHKFPAIIGQTQLLSITVQVGRTGTLTPVAELEPIEIGGVTVSRATLHNFQEIARKDVRIKDYVFLQRAGDVIPKIMGVDFDKRPNDTATFDTPLFCLSCNSKLHYMPEDIIIRCDNGLNCPAQNYERIRHFVSKNAMDIEGLGRKQVEFLIDKGLISNPLDIFFLKEKNDSSLAKLENMDGWGKKSVENLFKNIEKSKNVSLPRFIYALGIRHIGEQNAKLLAREVGSYNNFIAQMELLRTNEPDIYQKLNNLEGIGDKILVDIIDFFDVKENIELIKKLGEILNIEDYKETREQSSLTDKIVVFTGSLPTISRAEAKATAEKLGAKVTAGVSSNTDLVVAGVDAGSKLKKAKELNIKIIDEEEWLTLIKNV
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: NADK_BORA1
Sequence: MHFPIVALIGRYQDTGLDAPLRALAAMLTQAGRRVLVDADTARNTAVHEYPVATMQEIGESASLAVVMGGDGTVLGVARHLAPYGVPLIGINHGRLGFITDIPLQDAHDALARVLDGNFQIEERMLLQGSVWRGDALMYTASALNDVVLNRAGRGGMIEMRVELDGVYMYTQRADGLIIATPTGSTAYALSANGPLLHPGLNAMVLVPVAPQSLSNRPIVIPDTGVLNMTLTAIGRVETGASAHFDMQTWSDLQLGDRITVQRAPHTARLVHPQGYSFFSTLRRKLHWNQMPQVSDNIE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_THEVO
Sequence: MMPPDYVFGLIGHPVSHSIGQIVYNRYFQKKGLNAIYLSIDIFPETLKYFMSYASKMDGFNVTIPHKISIMDYLDQIDWEARSIGSVNLVKTEDGLLKGFNTDYYGIEYMFKKGGVDVSGKSIVVAGSGGIARTVIHYLIKNNAKSVTVKARDVKLAKNKLNAYDVDIKEYANNDYDIYINCTPLGTEAVGDPFPEVQFGKGKIAVDVVYNPPVTPFLKRAGISGSKTLSGLDLYIGQAIKTLDILTSGCDIDTLINSVRVAVNEVR
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: KUNPM_ORNKA
Sequence: MQANIFVFAFLLLSVAVAAYGYQPECLEPSLYGCRGDEDATFGWTFDREDGGCRQGSYCTRFGQPKNYFRSEGDCKKACGGA
What is the function of this protein?
Tick salivary platelet aggregation inhibitor that plays an important part in the anti-hemostatic strategy of ticks (PubMed:11932256).  Inhibits platelet aggregation induced by ADP (IC(50)=130 nM), collagen, the thrombin receptor-activating peptide, and epinephrine, although platelets are activated and their shape changed (PubMed:11932256).  Binding to platelets is similar for resting and activated platelets (Kd=50-70 nM) (PubMed:15147758).  Acts by specifically binding to platelet membrane glycoprotein IIb-IIIa (ITGA2B/ITGB3) in a divalent metal ion dependent manner (Probable) (PubMed:15147758).  In contrast to many disintegrins which only interacts with the beta-3 subunit, this protein interacts with the two subunits (alpha-IIb and beta-3) (Probable).  Also causes disaggregation of aggregated platelets without influencing the activated spherical shape associated with aggregated platelets and causes a decrease in the number of pseudopodia on the activated platelet surface (PubMed:12593588).  Does not show any inhibitory activity for the different serine proteases tested (PubMed:11932256).
What are the official names of this protein?
Savignygrin (-), Platelet aggregation inhibitor, PAI.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Before secretion, is localized to dense core granule type 'a' and to granule type 'b', but not to granules 'c' or 'd'.
Protein: CWP20_SOLLC
Sequence: GYMKYKDPKQPLLGRRXD
What are the official names of this protein?
66 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: BEST2_HUMAN
Sequence: MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDAAEARAPYTAATVFQLRQPSFQGSTFDITLAKEDMQFQRLDGLDGPMGEAPGDFLQRLLPAGAGMVAGGPLGRRLSFLLRKNSCVSEASTGASCSCAVVPEGAAPECSCGDPLLDPGLPEPEAPPPAGPEPLTLIPGPVEPFSIVTMPGPRGPAPPWLPSPIGEEEENLA
What is the function of this protein?
Forms calcium-sensitive chloride channels.  Permeable to bicarbonate.
What are the official names of this protein?
Bestrophin-2, Vitelliform macular dystrophy 2-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.