PharMolix/UniProtQA huggingface dataset:
Protein: GP3_EAVBU
Sequence: MGRAYSGPVALLCFFLYFCFICGSVGSNNTTICMHTTSDTSVHLFYAANVTFPSHFQRHFAAAQDFVVHTGYEYAGVTMLVHLFANLVLTFPSLVNCSRPVNVFANASCVQVVCSHTNSTTGLGQLSFSFVDEDLRLHIRPTLICWFALLLVHFLPMPRCRGS
What is the function of this protein?
Minor envelope protein.  Part of the glycoproteins heterotrimer GP2b-GP3-GP4 which is probably responsible for the attachment to target host cell.  This attachment induces virion internalization predominantly through clathrin-dependent endocytosis.
What are the official names of this protein?
Glycoprotein 3, Protein GP3.
What is the protein family that this protein belongs to?
Belongs to the arteriviridae GP3 protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Secreted. Note=Only a small fraction of GP3 synthesized in infected cells ends up in virions. The signal sequence functions as an uncleaved signal when glycosylated at Asn-28 and Asn-29. When the protein is not glycosylated at these sites, the signal sequence is cleaved (PubMed:24142700).
Protein: ACPH_YERP3
Sequence: MNFLAHLHLAALADSSLLGNLLADFVRGNPQGEYPPEIVAGIMMHRRVDVMTDTLPLVKEARTYFSADYRRVSPITLDVLWDHFLARHWDQLVPNCALPDFLQHAQSQILPHLPHTPARFQSLNAYLWSERWLERYAELPFIADVLQGMANRRPKLAALAGSFYAIEQHYQPLEDLFLTFYPTMMQQAQHKQI
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: YBEY_LISIN
Sequence: MTVLEIDLLDETNNLPDEDKQLVENILQFAAGYLKIEEGTELSLTFTTNEGIQEINREYRNKDQATDVISFALEEMGDGETEIDWGDFDLETPRMLGDIIISTEKAEEQAKDYGHTKARELGFLAVHGLLHLLGYDHMEPDEEKVMFGLQKEVLDAYGLER
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VEMP_CVBON
Sequence: MFMADAYFADTVWYVGQIIFIVAICLLVIIVVVAFLATFKLCIQLCGMCNTLVLSPSIYVFNRGRQFYEFYNDVKPPVLDVDDV
What is the function of this protein?
Plays a central role in virus morphogenesis and assembly.  Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport.  Also plays a role in the induction of apoptosis.
What are the official names of this protein?
Envelope small membrane protein, E protein, sM protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses E protein family.
What are the subcellular locations of this protein?
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Protein: URK_LISMC
Sequence: MTKKPIVVGVTGGSGSGKTSVTKAICDHFSGHSILMIAQDVYYHDQANISFEDRLKVNYDHPLAFDTDLLISHIAALRRYETIEKPIYDYAKYTRKKEVEIQEPREVIILEGILILEDKRLRDLMDIKVYVDTDDDIRFIRRLLRDMKERGRTMDSVIEQYLSVVKPMHNEFIEPTKKFADIIIPEGGENHVAIDLMTTKIESILQKHV
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_BACLD
Sequence: MKIAVDAMGGDNAPKAVIEGVMKAVEDFEDLEITLIGDREKIAAHLTEHGRITVKHAEEVIEATDEPVRAVRRKKNSSMVLMAGEVAEGRADACISAGNTGALMTAGLFIVGRIEGIERPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSVYGEQVLGVKNPRIGLLNVGTEDKKGNELAKQTFQKLKETDLNFIGNVEARDMLDGVADVIVTDGFTGNVALKTVEGAALSIFKMLRTTLTSSFTAKLAASALKPKLKEMKTKMDYSEYGGAGLFGLKAPVIKAHGSSDGRAVYHAIRQAREMVSQNVAAFIEEKIQQKADE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RBSA2_BURL3
Sequence: MDTILRLSHITKSFPGVKALADIDLEIARGEIHALLGENGAGKSTLMKILCGIHQPDTGTIEIDGTARHFSDYHDAVAAGVGIVFQEFSLIPHLDAVDNLFLGRELRNRWGARDRKRMRHAAAAIFARLGVAIDLDAPIRALSVAQQQFVEIGKALSLDARILILDEPTATLTPAEAEHLFAIMRELKRQGVAMIFISHHLDEIFAVCDRITVLRDGQYVATTDVARTDVEQLVRMMVGRRIESSFPPKPVRAVDAPRVLEVNELQIERGGPVNRFTLHAGEILGFAGLVGSGRTETALAVIGATRAHRKDVRVRGAAVKLADPADALRAGIGILPESRKTEGLVTSFSIRDNISLNNLGKYRSMRWLIDRRGEARTTHDVMRRVGVKAPSIHTEVATLSGGNQQKVVIARWLNHHTSVLIFDEPTRGIDVGAKAEIYGLMRELTARGYAIIMISSELPEIVGMCDRVAVFRQGRIEATLEGDEIDPDTVMTYATAGTRGATHEPA
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PDXB_ECO55
Sequence: MKILVDENMPYARDLFSRLGEVTAVPGRPIPVAQLADADALMVRSVTKVNESLLAGKPIKFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSSLLMLAERDGFSLHDRTVGIVGVGNVGRRLQARLEALGIKTLLCDPPRVDRGDEGDFRSLDELVQHADILTFHTPLFKDGPYKTLHLADEKLIRSLKPGAILINACRGAVVDNTALLTCLNEGQKLSVVLDVWEGEPELNVELLTKVDIGTPHIAGYTLEGKARGTTQVFEAYSKFIGHEQHVALDTLLPAPEFGRITLHGPLDQPTLKRLVHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVICDDASAASLLCKLGFNAVHHPAR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C1GLC_BOVIN
Sequence: MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGSRMHHHEHHHLQAPNKEDILKISEDERMELSKSFRVYCILLVRPKDVSLWAAVKETWTNHCDKVDFFSSENVKVFESINMETNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTVKSGDLEYVSMEGGIVLSIESMKRLNSLLSIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDSEGKDIFNTKSVGLFIKEAMTNHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHVFNDALVFLPPNGSDND
What is the function of this protein?
Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.  Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity).
What are the official names of this protein?
C1GALT1-specific chaperone 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RISB_SHESH
Sequence: MNVVQGNIESKNAKIAIVVSRFNSFLVESLLEGAVDTLKRFGQVSDENITVVRVPGAVELPLAARRVAASGKFDGIIALGAVIRGGTPHFDFVAGECNKGLAQVALEFDLPVSFGVLTTDTIEQAIERSGTKAGNKGGEAALGLLEMVNVLQELEQQLQD
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: GP7_BPMU
Sequence: MAKVIIEIKNTVSGIKGRNLRTSIAVDGSAELDGDEGTLAGMVALLVLNKSQKIINESAHEAIEILKNDGVITSGRVTEMAVEKTCH
What are the official names of this protein?
Uncharacterized protein gp7, E6, Gene product 7, gp7.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: GL85_ORYSJ
Sequence: MASPSSLCLLAALALISWQAMASDPSPLQDFCVADMHSPVRVNGFACLNPMEVNADHFFKAAKLDTPRKTNKVGSNVTLINVMQIPGLNTLGISIARIDYAPLGQNPPHTHPRATEILTVLEGTLYVGFVTSNPNNTLFSKVLNKGDVFVFPQGLIHFQFNPNPHQPAVAIAALSSQNPGAITIANAVFGSKPPISDEVLAKAFQVEKGTIDWLQAQFWENNHY
What is the function of this protein?
Plays role in broad-spectrum disease resistance.  Probably has no oxalate oxidase activity even if the active site is conserved.
What are the official names of this protein?
Germin-like protein 8-5.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: ATPB_SALSV
Sequence: MATGKIVQVIGAVVDVEFPQDAVPRVYDALEVQNGNEKLVLEVQQQLGGGIVRTIAMGSSDGLRRGLDVKDLEHPIEVPVGKATLGRIMNVLGEPVDMKGEIGEEERWAIHRAAPSYEELSNSQELLETGIKVIDLMCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMTDSNVIDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRQIASLGIYPAVDPLDSTSRQLDPLVVGQEHYDTARGVQSILQRYQELKDIIAILGMDELSEEDKLVVARARKIQRFLSQPFFVAEVFTGSPGKYVSLKDTIRGFKGIMEGEYDHLPEQAFYMVGSIDEAVEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NADE_BURO1
Sequence: MTSADYASRQRAIIAELNVAPHFDAEAEIARRIDFLAQYLRSTGLRTYVLGISGGVDSSTAGRLAQLSVERLRADGYDARFIAMRLPNGVQNDEEDAQRALAFVRADEVLTVDVKPAADAMLRSLVASGHAFETPAQQDFVHGNIKARERMIAQYAVAGARRGIVIGTDHAAESLMGFFTKFGDGGADILPLAGLSKRRVRGVARALGGEELIVMKVPTADLEELRPLRPDEHAYGVTYDEIDDFLEGKPVADRVYETVLRFYDGSRHKRALPYTMFDWPAA
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: KRUP_CUPSA
Sequence: MRLHTGEKPYHCFHCDRHFVQVANLRRHLRVHTGERPYSCTLCPSR
What is the function of this protein?
Krueppel is a gap class segmentation protein.
What are the official names of this protein?
Protein krueppel.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TX22_PHONI
Sequence: MPCPKILKQCKSDEDCCRGWKCFGFSIKDKMCISR
What is the function of this protein?
Neurotoxin.
What are the official names of this protein?
U14-ctenitoxin-Pn1a, U14-CNTX-Pn1a, Neurotoxin PNTx22A0C1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I7 (squash-type serine protease inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: URE2_HALWD
Sequence: MSNITPGELIPADKPVEINADRETTSVTVENTGDRPSQVGSHFHFFETNPALSFDRKSAYGMRLDIPAGTAIRFEPGCEKDVDLVAIGGDRIVKGMGGLVNGELDADETREQAFERARNADYMEEQ
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR_STAA2
Sequence: MAKVLYITAHPFNELVSNSMAAGKAFIETYQQQHPDDEVKHIDLFETYIPVIDKDVLTGWGKMSNGETLTDDEQMKVSRLSDILEEFLSADKYVFVTPMWNLSFPPVVKAYIDAISIAGKTFKYSAEGPQGLLTDKKVLHIQSRGGYYTEGPAADFEMGDRYLRTIMTFLGVPSYETIIIEGHNAEPHKTEEIKATSINNAEKLATTF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: NGL1_YEAST
Sequence: MFTRRFIPVVQSTKQNIGKYVRKDARFTLLTYNMLSPSYMWPQVYTYVAEPYKNWSYRHRLLEKELLNTFKADIMCLQEMTARDYEDYWHDSIGVDVNYGSKFISKTPPKYWKKPVKDMDGVSIFYNLAKFDFISSSGIYLNQLLNVFNQRELKYLYNKKVTLTDGASNVIGEDSLLDVLKGKNQVCLFVSLRHKETGTIFVVLNTHLYWKYDEVKLTQCMIIMRELSKIIKQLLPGDVKGQERVKILFTGDLNSTRDSLVVNFLQGQIVSHGDLNLINPMRPYLDRCVYDDIPKDYFVHTCYSGKLKGIFDYVWYHDSDFLLTKILTGNEVSDELLASNQLGLPNENHPSDHIPLLTEFKIL
What are the official names of this protein?
RNA exonuclease NGL1.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MTOX_SALA4
Sequence: MKYDLIIIGSGSVGAAAGYYATRAGLKVLMTDAHMPPHQQGSHHGDTRLIRHAYGEGEKYVPLVLRAQTLWDELSTHNEEPIFVRSGVVNLGPADSAFLANVARSAQQWQLNVERLDATALMTRWPEIRVPDNYIGLFEADSGFLRSELAITTWLRLAREAGCAQLFNSPVSHIHHDDNGVTIETSEGSYHASKALISAGTWVKALVPELPVQPVRKVFAWFKADGRYSTKNRFPAFTGEMPNGDQYYGFPAENDELKIGKHNGGQLIQAPEERKPFAAVASDGAEAFPFLRNVLPGIGGCLHGAACTYDNSPDEDFIIDTLPGHENTLVITGLSGHGFKFAPVLGEIAADFALGKTPSFDLTPFRLSRFSQ
What is the function of this protein?
Catalyzes the oxidative demethylation of N-methyl-L-tryptophan.
What are the official names of this protein?
N-methyl-L-tryptophan oxidase, MTOX.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family. MTOX subfamily.
Protein: YFCN_ECO55
Sequence: MKKKTTLSEEDQALFRQLMAGTRKIKQDTIVHRPQRKKISEVPVKRLIQEQADASHYFSDEFQPLLNTEGPVKYVRPDVSHFEAKKLRRGDYSPELFLDLHGLTQLQAKQELGALIAACRREHVFCACVMHGHGKHILKQQTPLWLAQHPHVMAFHQAPKEYGGDAALLVLIEVEEWLPPELT
What are the official names of this protein?
UPF0115 protein YfcN.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: UCN2_HUMAN
Sequence: MTRCALLLLMVLMLGRVLVVPVTPIPTFQLRPQNSPQTTPRPAASESPSAAPTWPWAAQSHCSPTRHPGSRIVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC
What is the function of this protein?
Suppresses food intake, delays gastric emptying and decreases heat-induced edema.  Might represent an endogenous ligand for maintaining homeostasis after stress.
What are the official names of this protein?
Urocortin-2, Stresscopin-related peptide, Urocortin II, Ucn II, Urocortin-related peptide.
What is the protein family that this protein belongs to?
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
What are the subcellular locations of this protein?
Secreted.
Protein: DUT_MYCBO
Sequence: MSTTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRALVRTGVAVAVPFGMVGLVHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAAPIVVHRGDRIAQLLVQRVELVELVEVSSFDEAGLASTSRGDGGHGSSGGHASL
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RIMK_CELJU
Sequence: MKIAILSRNRRLYSTRRLVEACTQRGHEVRVIDILKCYIDIASASPAIWYMGEKLEGFDAVIPRIGASVTHYGLAVIRQFEMMGVYCLTESIALGRSRDKLRALQLLSRKGIGLPKTSFAYNVYDARELIKLVGGTPLVLKLCEGTQGKGIVLAETQKAAESVIEAFRELRAEFLVQEFIKEANGSDVRCFVVGDKVVASMERTAQDGEFRSNLHRGGTAKVTKLSPTERRTAIKAAQTMGLKVAGVDLLRSSRGPLVMEVNSSPGLEGIESATGKDIAGLIVAYMEENAKPVTTTRAGKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: EF114_ARATH
Sequence: MYGKRPFGGDESEEREEDENLFPVFSARSQHDMRVMVSALTQVIGNQQSKSHDNISSIDDNYPSVYNPQDPNQQVAPTHQDQGDLRRRHYRGVRQRPWGKWAAEIRDPKKAARVWLGTFETAESAALAYDEAALKFKGSKAKLNFPERVQLGSNSTYYSSNQIPQMEPQSIPNYNQYYHDASSGDMLSFNLGGGYGSGTGYSMSHDNSTTTAATTSSSSGGSSRQQEEQDYARFWRFGDSSSSPHSGY
What is the function of this protein?
Transcriptional regulator of cell proliferation and axillary bud outgrowth.  Involved in maintaining the structure of the shoot apical meristem as well as plastochron and phyllotaxy.  Activates several genes involved in cell cycle regulation and dormancy breaking, including CYCD3-3, DPA, and BARD1.  Strongly down-regulates DRM1, DRMH1, MARD1 and several genes encoding different types of cell wall-remodeling proteins.
What are the official names of this protein?
Ethylene-responsive transcription factor ERF114, ERF bud enhancer.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RBM11_MOUSE
Sequence: MFPAQEEADRTVFVGNLEARVREEILYELFLQAGPLTKVTLCKDRDGKPKSFGFVCFKHPESVSYAIALLNGIRLYGRPINVQYRFGSSRSSEPANQSFESCAKINSHSFRNDEMAGRPSFPVPFFPITSAALPQEYFFFQKMPWYAHSPVLQPPFCEMPAPLPNSVPGSCALNHSPGPEAGPSSYEWTHQPPSDPDLYPRNKRKRQRPDSDSDSSSEDKRGNEGSQKCRKCKKKKRY
What is the function of this protein?
Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation.  Antagonizes SRSF1-mediated BCL-X splicing.  May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 (By similarity).
What are the official names of this protein?
Splicing regulator RBM11, RNA-binding motif protein 11.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus speckle. Note=Enriched in SRSF2-containing splicing speckles; shuttles between nucleoplasm and speckles.
Protein: MP2K6_MOUSE
Sequence: MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHESKAADVASFVKLILGD
What is the function of this protein?
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.  With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses.  Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF.  MAP2K6/MKK6 also phosphorylates and activates PAK6.  The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors.  Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1.  Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation.  The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription.  Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway.  MAP2K6/MKK6 mediates apoptotic cell death in thymocytes.  Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, MEK 6, SAPKK3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Binds to microtubules.
Protein: WNT7A_HUMAN
Sequence: MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).  Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533).  Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314).  Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity).  Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity).  Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity).  Promotes formation of synapses via its interaction with FZD5 (By similarity).
What are the official names of this protein?
Protein Wnt-7a.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: RL15_CAUSK
Sequence: MTKLNELAPAPGSTKGRMRVGRGPGSGKGKTAGRGVKGQKARSGVAIAGFEGGQMPLHMRMPKRGFNNPFRLEFAEVNLWRLEQAVEAGKLKAGADVSVADLVAAGVIRRELDGVKLLGKGEIKSALKLTVYSATEAAIKAVEAAGGSVTVTKKAKVQAEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PSBJ_NYMAL
Sequence: MADTTGRIPLWLIGTVTGILVIGLIGVFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MDH_RHORT
Sequence: MARKKIALVGAGNIGGTLAHLIGLKELGDVVLFDIAEGTPQGKALDIAESTPIEGVDASYSGSNDYAAIKDADVVIVTAGVPRKPGMSRDDLIGINAKVMSAVGQGIRANCPNAFVICITNPLDAMVWVLREVSGLPHNKVVGMAGVLDSARFRYFLSEEFNVSVKDVNAFVLGGHGDTMVPLPRYSTVAGIPLPDLVKMGWTTQEKLDQIIQRTRDGGAEIVGLLKTGSAFYAPAAAAVQMAEAYLKDQKRVLPCAAWVEGQYGLDGIYVGVPTIIGAGGIEKVIEIELNADEKAAFAKSVDSVRGLIAASKELMPK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.