PharMolix/UniProtQA huggingface dataset:
Protein: FTSKL_DEIRA
Sequence: MRRLQREIRTYDEEQLKQVREELTTYDLMTRNALLQTAHDLRAKVEQEAVPEGEQATTYLKAVVDDRRHELSVFLPATQASAALENVRRHLVNQILSIGGKAKKLETERCAAERHLKRPTVEVVQREHDAHLRRLRQWQEVQSRFQTWHTYEQAYARWPDLAAAFDSGPTEAATRVATELHKRTLATMQEQDRWREFLRQATEQEHQRQLTPPEDDLPEDDLEEDTWAAAESSEPSGSLFSRLGHTLSRLMAPPGPDEVPSAATAPRETDGWDDVQPQIAPDPRSTVPGLWDDADDLTPVSPVAPARPAPSPPVYDAAAVPALDIDFSAAPRRSRTPAEQMPDPFARAARVRSARRTTTPLVPVPQQLDAAEMPAPRPARTPPGRPATAGNVAPPSAPRTARPPSPTLADFDLWDDEEDMPFGPPATPAPAAASVPQMVPTPRAAARPTPRPVSSPGPSPVPVSPASASVSHAAPWEEPAAGRPAPAPSGVSRRGATRLALPSEQLLDPLPNGARNTVQMDLDAERRGDMINETLRQFGLQAKVVDLARGPTVTRYEIEPAPGEKISRIASLSNDLARALAVGGVRVEAPVPGKSVIGLEVPNAEREPVTFHQATANPAFKNTRAKLPIILGKSIDGSMMVGDLAKMPHLLVAGSTGSGKSVCVNTLITSLLYRYLPTELRFVMIDPKMVELTPYDGIPHLVRPVVTNPADAAGVLLGAVAHMERRYKMMSQVGAKNLEQFNAKMRAVGEVELPHLVIIIDELADLMITSPKEVESAIMRLAQMARATGMHLILATQRPSVDILTSLIKVNIPARIAFAVSSSHDSRTILDTTGAERLTGMGDMLFYQPGLVKPLRLQGPYISEAESARITDELRRMMFDDDFIEAYGADFEGMISSSGPGGDRSQLDFSDPLLRQAALVCIEEGQGSVSRLQRRLSVGHARAGKLMDLLEAMNIVGPHQGSKPREVLIHEADLPEYFGK
What is the function of this protein?
Probable DNA motor protein.  May track DNA in a ATP-dependent manner by generating positive supercoils in front of it and negative supercoils behind it (By similarity).
What are the official names of this protein?
Uncharacterized FtsK-like protein DR_0400.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
Protein: CLSA_ECO8A
Sequence: MTTVYTLVSWLAILGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLAVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAEENSSVAAPLFKLCERRQGIAGVKGNQLQLMTESDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWPELMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMIMIDNYIAYTGSMNMVDPRYFKQDAGVGQWIDLMARMEGPIATAMGIIYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTAAYSAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSMLVGWASRAFFTELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLAIDDKGFGADLAAVQDDYISRSRLLDARLWLKRPLWQRVAERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTR1B_XENLA
Sequence: HSFVYEKLFSLWNTILYVCLIWTLTVVATVPNFFVGSLEYDPRIYSCTFVQTVSSSYTITVVVIHFILPITVVTFCYLRIWILVIQVRRKVKSEFKPRMKQSDFRNFLTMFVVFVIFAFCWAPLNFIGLAVSINPTEVAPKIPEWLFVVSYF
What is the function of this protein?
High affinity receptor for melatonin.  The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).
What are the official names of this protein?
Melatonin receptor type 1B, Mel-1B-R, Mel1b receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NRDR_AGRVS
Sequence: MRCPFCGSDDTQVKDSRPAEDNSAIRRRRICPDCGGRFTTFERVQLRELTVLKKTGRKAPFDRNKLVRSFEIALRKRPVDRDRIERAVSGIVRRLESSGETEISSEQIGLQVLEALKSLDDVAFVRYASVYRDFSHAEDFEQVISEITAKISQDHEPG
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: HEMH_RIPO1
Sequence: MDRVGVLLLNLGGPEQLEDVRPFLFNLFSDPEIIRLPFPWLQKPLAWLISSLRSEKSQENYKQIGGGSPLRKITEAQAEALEQRLAEIGHTAQIYIGMRYWHPFTEEAIARIKRDRLKNLVILPLYPQFSISTSGSSFRVLEEMWNADPQLKAINYTLIPSWYDDPRYLAAMADLIAQELDKCEEPNRVHIFFSAHGVPQSYVDEAGDPYQAEIEACTRLIMQTLNRPNDYTLAYQSRVGPVEWLKPYTEDALKELGEQGVQDLLVVPISFVSEHIETLQEIDIEYREVAEEAGIENFYRVPALNTHPVFIDSLAQLVTKSLQEPPCTFNQVIHPKENMKMYPQERWQWGLTTAAEVWNGRLAMVGFIALLIELISGHGPLHFVGLL
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOA1_HUMAN
Sequence: MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ
What is the function of this protein?
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).  As part of the SPAP complex, activates spermatozoa motility.
What are the official names of this protein?
Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: YBEY_AGRVS
Sequence: MKKLDVQIAIEADGWPDEAELEALSTRILDHAADFIAAEGQPFAPMPAEVSLVFTGDTEIQAINSEWRGQDKPTNVLSFPAYPIEPGDKPGPMLGDIVIARQTVEREAAELEKTITDHLTHLMVHGFLHLFGYDHMTEDEAEEMEGLETRILAGLGLSDPYAGQVPV
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IXTPA_STRR6
Sequence: MLIATRNEGKTKEFRAIFDKLGYDVENLNDYPDLPEVAETGMTFEENARLKAETISQLTGKMVLADDSGLKVDVLGGLPGVWSARFAGVGATDRENNAKLLHELAMVFELKDRSAQFHTTLVVASPNKESLVVEADWSGYINFEPKGENGFGYDPLFLVGETGESSAELTLEEKNSQSHRALAVKKLLEVFPSWQSKPSL
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: GLMU_COREF
Sequence: MSASDSSSAVVVLAAGAGTRMKSDLQKTLHSIGGRSLISHSLHAAAGLNPTHIVAVIGHGRDQVGPAVEDVATHLGREVRIAIQEEQNGTGHAVQCAMDQLEGFDGTIIVTNGDVPLLTSDTLGSLLAAHTATPTAVTVLTMNLDDPTGYGRIVRNADGEVTAIVEQKDASDEERSITEVNSGVFAFDATILRSALSQLKSDNAQGELYLTDVLGIARSEGHPVRAHIAADARELAGVNDRVQLAEAGAELNRRTVEAAMRGGATIVDPATTWIDVEVTIGRDVLINPGTQLRGTTSIGDRAEIGPDTTLTNMVIGTGASVIRTHGSDSEIGEDATVGPFTYIRPGTKLGAEGKLGGFVETKKATIGRGSKVPHLTYVGDATIGEYSNIGASSVFVNYDGVNKNHTTIGSHVRTGSDTMFIAPVTVGDGAYSGAGTVIKDDVPPGALAVSGGRQRNIEGWVQKKRPGTAAADAAAAAQNSVPNQEG
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_RHILW
Sequence: MARYVFITGGVVSSLGKGIAAAALGALLQARGYRVRLRKLDPYLNVDPGTMSPTQHGEVFVTDDGAETDLDLGHYERFTGRSATKTDNITTGRIYKNIIDKERRGDYLGATVQVIPHVTNEIKDFVIEGNDDYDFVICEIGGTVGDIEAMPFMEAIRQLGNDLPRGTAVYVHLTLMPYIPAAGELKTKPTQHSVKELQALGIHPDILLVRADREIPEAERRKLSLFCNVRPSAVIQALDVANIYDVPIAYHKEGLDDEVLAAFGIEPAPKPRLDPWEEVCNRIRTPEGEVTIAIVGKYTGLKDAYKSLIEALHHGGIANRVKVKLEWIESEVFEKEDPAPYLEKVHGILVPGGFGERGSEGKIHAARFARERKVPYFGICFGMQMAVIEAARNLADVSGASSTEFGPTKEPVVGLMTEWVKGNELQKRTAAGDLGGTMRLGAYKAALKKGTKISDIYGSTDISERHRHRYEVNVDYKDRLESCGLVFSGMSPDGVLPETIEYPDHPWFIGVQYHPELKSRPLDPHPLFASFIEAATEQSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: ADA2C_HUMAN
Sequence: MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
What is the function of this protein?
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
What are the official names of this protein?
Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PVK2_PRAMA
Sequence: SGLQFAVLDGQGFLPFPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
CAPA-Periviscerokinin-2, CAPA-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YBJQ_SALPK
Sequence: MQFSTTPTLEGQSIVEYCGVVTGEAILGANIFRDFFAGIRDIVGGRSGAYEKELRKAREIAFQELGEQAKALGADAVVGIDIDYETVGKDGSMLMVSVSGTAVKTRR
What are the official names of this protein?
UPF0145 protein YbjQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: MURA2_STAES
Sequence: MAQEVIKIRGGQALKGEVEISGAKNSAVAIIPATLLAQGQVKLEGLPQISDVETLVSLLEDLNIEARLNGKQLEVDTTQIENAPLPNNKVESLRASYYMMGAMLGRFKKCVIGLPGGCPLGPRPIDQHIKGFKALGAEIDESSNTSMKLVAKELRGAHIFLDMVSVGATINIMLAAVHAKGQTVIDNAAKEPEVVDVANFLMSMGADIRGAGTTSIKINGVEELKGSEYQIIPDRIEAGSYMCMAAAMGEEVILHNIVPKHVEALTVKLQELGVDIEIEDEKIIIRKQTPYKNVDIKTLVYPGFATDLQQPITPLLFMTEGPSFVTDTIYPARFKHVEELQCMGANIKSDEGTAVIKPSTLNGAEVYASDLRAGACLITAGLIAEGVTTIFNVKHIYRGYTNIVEHLKALGADIWTETV
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2, Enoylpyruvate transferase 2, UDP-N-acetylglucosamine enolpyruvyl transferase 2, EPT 2.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y015_SYNE7
Sequence: MIITIDALLDAAQLNKIQSSLQTAEFIDGRATAGWHAQLVKQNQQLSRTSTLAKSLQEIVQTALQNNALFEAAAYPQRVHSLLFSRYEPGMEYGRHVDNALMGSGDRRDRADLSFTLFLSDPDRYIGGALVIEGACDEQAYRLPAGSLLLYPSSTLHRVDPVEQGYRFACVGWVQSWIRDPAKRELLFDLDTARRSLFTREGKSIEFDLLSKTYANLLRRWSE
What are the official names of this protein?
PKHD-type hydroxylase Synpcc7942_0015.
Protein: ISDF_STAAR
Sequence: MMIKNKKKLLFLCLLVILIATAYISFVTGTIKLSFNDLFTKFTTGSNEAVDSIIDLRLPRILIALMVGAMLAVSGALLQAALQNPLAEANIIGVSSGALIMRALCMLFIPQLYFYLPLLSFIGGLIPFLIIILLHSKFRFNAVSMILVGVALFVLLNGVLEILTQNPLMKIPQGLTMKIWSDVYILAVSALLGLILTLLLSPKLNLLNLDDIQARSIGFNIDRYRWLTGLLAVFLASATVAIVGQLAFLGIIVPHVVRKLVGGNYRVLIPFSTVIGAWLLLVADLLGRVIQPPLEIPANAILMIVGGPMLIYLICQSQRNRI
What is the function of this protein?
Part of the binding-protein-dependent transport system for heme-iron.  Responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Probable heme-iron transport system permease protein IsdF, Iron-regulated surface determinant protein F, Staphylococcal iron-regulated protein G.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYDND_BACC2
Sequence: MAERTHACGKVTVEAVGQTVQLKGWVQKRRDLGGLIFIDLRDRTGIVQVVFNPETSKEALEVAETIRSEYVLHVEGTVVERGEGAINDNMATGRIEVQATKVNVLNAAKTTPIIIADDTDASEDVRLKYRYLDLRRPVMFNTFKMRHDVTKTIRNFLDTEEFLEVETPILTKSTPEGARDYLVPSRVHDGEFYALPQSPQLFKQLLMVGGFERYYQVARCFRDEDLRADRQPEFTQIDIEASFLTQDEILDMMERMMTKVMKDAKGVEVSAPFPRMKYADAMARYGSDKPDTRFEMELTDLSEFAAGCGFKVFTSAVESGGQVKAINAKGAASKYSRKDIDALTEFVKVYGAKGLAWLKVEEDGLKGPIAKFFGEEDANVLMTTLEATAGDLLLFVADKKSVVADSLGALRLRLGKELELIDESKFNFLWVTDWPLLEYDEDADRYFAAHHPFTMPFREDVELLETAPEKARAQAYDLVLNGYELGGGSLRIYERDVQEKMFKALGFSQEEAQEQFGFLLEAFEYGTPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCLLTEAPSPVAEAQLEELNLKLSLKEEK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C624_CONCL
Sequence: MKLTCVMIVAVLVLTVCKVVTSDQLKKLRRECYLEPGDSCFHDDGRGACCEGTCFFGVACVPWS
What is the function of this protein?
Probable neurotoxin.
What are the official names of this protein?
Conotoxin Cal6.24, O1_cal6.24.
What are the subcellular locations of this protein?
Secreted.
Protein: ORF9_SPV4
Sequence: MAYRGFKTSRVVKHRVRRRWFNHRRRYR
What are the official names of this protein?
Uncharacterized protein ORF9.
Protein: AT222_EMENI
Sequence: MASFSQLASSPEEPDFERRFLRYRGEDTSPTGRREIWGWYAYGVAAEVFAVCGVGSFLPLTLEQLAREQGFLSSSHLPCVGPDAPPAAGNGTAPANEACVVPLMGLEINTASFAMYTFSLAVLIQALTLVSFSALADYENNRKALLLAFGFIGSATSMLFMLIVPPVFVLGALLVVIGVTCLGSSFVVLNSFLPILVANDPSVQRASNKNKDDLHDLHTEGDEFSLRSWTDEEDTGDHAGPAGSKKAVEPEKASSSTSPELQLSTRISSRGVGLGYCAAVLVQILSILLLFTLSKTSMGKSHPTLPLRFVLLLVGIWWAAFTVVCSRWLRSRPGPPLEGVTPGAGYRQKWRVWLRVVGFAWKSLWNTIKVALRLREVVVFLAAWFLISDAIATVSGTAILFARTELHLSTVSVGLLSITATMSGMAGAFLWPIVARRFALASNHTILLCIALFEIIPLYGMLAYIPFIRNWGVLGLQKPWEIFPLGIVHGVVSGGLASYCRSLFGELIPPGSEAAFYALYAATDKGSSFVGPAIVGALIDATGSVRSGFIFIGVLILLPMPLVWLVNAERGRQDAIAMVKHAPNSEEGEGLLR
What is the function of this protein?
Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation.  The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity).
What are the official names of this protein?
Autophagy-related protein 22-2.
What is the protein family that this protein belongs to?
Belongs to the ATG22 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Vacuole and punctate structures.
Protein: SPX3_HUMAN
Sequence: MAWPNVFQRGSLLSQFSHHHVVVFLLTFFSYSLLHASRKTFSNVKVSISEQWTPSAFNTSVELPVEIWSSNHLFPSAEKATLFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGLLVSPEEIGLSGIEAEENFEEDSHRPLINGGENEDEYEPNYSIQDDSSVAQVKAISFYQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLQGFISDVLQKRAPVLALSLLLAVGSLIGYSRSPNDKSINALLMTVTGFFIGGPSNMISSAISADLGRQELIQRSSEALATVTGIVDGSGSIGAAVGQYLVSLIRDKLGWMWVFYFFILMTSCTIVFISPLIVREIFSLVLRRQAHILRE
What is the function of this protein?
Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity (PubMed:21949678).  In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containg-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899).
What are the official names of this protein?
Sugar phosphate exchanger 3, Solute carrier family 37 member 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Protein: ATL73_ARATH
Sequence: MARFLLATQATPTISATDANPRTLGDSVSNNKNIASMDTHMVIILAALLCALICALGINSVLRCVLRCTRRFTPNEDPVDTNANVAKGIKKRALKVIPVDSYSPELKMKATECLICLGDFVEGETVRVLPKCNHGFHVKCIDTWLLSHSSCPTCRQSLLEHQTPANGSRRGDDVAT
What are the official names of this protein?
RING-H2 finger protein ATL73, RING-type E3 ubiquitin transferase ATL73.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y0148_MYCTU
Sequence: MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDGTGAGSAMADEVVAEIRDKGGRAVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGILRDGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGLFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHANALAPIAATRMTQDILPPEVLEKLTPEFVAPVVAYLCTEECADNASVYVVGGGKVQRVALFGNDGANFDKPPSVQDVAARWAEITDLSGAKIAGFKL
What are the official names of this protein?
Putative short-chain type dehydrogenase/reductase Rv0148.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: CML9_ORYSJ
Sequence: MAAKLTQEQVDECREIFDLFDSDEDGRIAAGELVTALRSLGQNVDEAEARRFLADATASGGGGGGGGDIDFAAFLSVAARKMRRGATEKELAACLDVFDDARSGVIPAEQLRQAMVSHGDRLTEEEADEMVRKADPAGEGRVEYKEFVKVLMNNK
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML9, Calmodulin-like protein 9.
Protein: UPPP_SACEN
Sequence: MQAMVLAVVQGLTEFLPISSSGHLSIVSKLFFGSDAGASFTAVTQIGTELAVVIYFAGDIVRLVVTWFRGLVNAEVRRTQDYRLAWYVIVGSLPIGVLGFLFQDYIRGALRSLWITGAMLILFGILMGLAERFGAQRRGHDKLTMRDGVLMGSAQALALIPGVSRSGGTITAGLSLGLDRPTAVRFSFLLAIPAVFAAGVSEVSHVFEPSAHGLQPTGAQMIVATVVAGVVGYAVIAWLLRYVQKHSVYLFVWYRIVLGLVLFGLLGFGVIQP
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ASAH2_MOUSE
Sequence: MAKRTFSTLEAFLIFLLVIMTVITVALLTLLFVTSGTIENHKDSGNHWFSTTLGSTTTQPPPITQTPNFPSFRNFSGYYIGVGRADCTGQVSDINLMGYGKNGQNARGLLTRLFSRAFILADPDGSNRMAFVSVELCMISQRLRLEVLKRLESKYGSLYRRDNVILSAIHTHSGPAGFFQYTLYILASEGFSNRTFQYIVSGIMKSIDIAHTNLKPGKIFINKGNVANVQINRSPSSYLLNPQSERARYSSNTDKEMLVLKLVDLNGEDLGLISWFAIHPVSMNNSNHFVNSDNMGYAAYLFEQEKNKGYLPGQGPFVAGFASSNLGDVSPNILGPHCVNTGESCDNDKSTCPNGGPSMCMASGPGQDMFESTHIIGRIIYQKAKELYASASQEVTGPVLAAHQWVNMTDVSVQLNATHTVKTCKPALGYSFAAGTIDGVSGLNITQGTTEGDPFWDTLRDQLLGKPSEEIVECQKPKPILLHSGELTIPHPWQPDIVDVQIVTVGSLAIAAIPGELTTMSGRRFREAIKKEFALYGMKDMTVVIAGLSNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRDLAKAIATDTVANMSSGPEPPFFKNLIASLIPNIADRAPIGKHFGDVLQPAKPEYRVGEVVEVIFVGANPKNSAENQTHQTFLTVEKYEDSVADWQIMYNDASWETRFYWHKGILGLSNATIYWHIPDTAYPGIYRIRYFGHNRKQELLKPAVILAFEGISSPFEVVTT
What is the function of this protein?
Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10753931, PubMed:10652340, PubMed:16380386).  Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:14557071).  Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:10652340, PubMed:21613224).  Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:16126722).  Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (PubMed:16126722).  This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (PubMed:16380386).
What are the official names of this protein?
Neutral ceramidase, N-CDase, NCDase, Acylsphingosine deacylase 2, N-acylsphingosine amidohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the neutral ceramidase family.
What are the subcellular locations of this protein?
[Neutral ceramidase]: Cell membrane; Single-pass type II membrane protein. Membrane raft; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Mitochondrion. Secreted, extracellular exosome. Note=Enriched in exosomes upon stimulation by cytokine (By similarity). Enriched in caveolae and lipid rafts (PubMed:12921776). SUBCELLULAR LOCATION: [Neutral ceramidase soluble form]: Secreted.
Protein: NPD_CAMJE
Sequence: MKNIMILSGAGLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRAQLQNVKPNHAHEKIAQLKEKWGKNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEGIFNIGYEKFTDKQCPKCKSKDLRHNIVMFEEQAPAYATLYSLLHQTSLFISIGTSGAVLPVGQYASMCEKSILNIYEKDVNLERYFDKIYIEDIISAIDKIALDIENFMKDGNV
What is the function of this protein?
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins.  Modulates the activities of several proteins which are inactive in their acylated form.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK3_SOLLC
Sequence: METFLFTSESVNEGHPDKLCDQVSDAILDACLEQDPESKVACETCTKTNMVMVFGEITTKATVDYEKIVRDTCRGIGFVSADVGLDADNCKVLVNIEQQSPDIAQGVHGHLTKKPEEIGAGDQGHMFGYATDETPELMPLTHVLATKLGAKLTEVRKNKTCPWLRPDGKTQVTVEYKNDNGAMVPIRVHTVLISTQHDETVTNDQIAQDLKEHVIKPVIPAKYLDENTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSVVASGLARRCIVQVSYAIGVAEPLSVFVDTYKTGTIPDKDILVLIKENFDFRPGMMSINLDLLRGGNYRYQKTAAYGHFGRDDPDFTWETVKVLKPKA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 3, AdoMet synthase 3, Methionine adenosyltransferase 3, MAT 3.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.