PharMolix/UniProtQA huggingface dataset:
Protein: MTNB_MOUSE
Sequence: MSGCQAQGDCCSRPCGAQDKEHPRFLIPELCKQFYHLGWVTGTGGGISLKHGNEIYIAPSGVQKERIQPEDMFVCDINEQDISGPPASKKLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGQEFKITHQEMIKGIRKCTSGGYYRYDDMLVVPIIENTPEEKDLKERMAHAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVSMKKMGLDPTQLPVGENGIV
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).  Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation.  May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase, APAF1-interacting protein, Monocyte/macrophage protein 19.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_STAA9
Sequence: MSNVTPMMQQYLKIKSEYQDCLLFFRLGDFYEMFYEDAKEASRVLEITLTKRDAKKENPIPMCGVPYHSADSYIDTLVNNGYKVAICEQMEDPKQTKGMVRREVVRIVTPGTVMEQGGVDDKQNNYILSFVMNQPEIALSYCDVSTGELKVTHFNDEATLLNEITTINPNEVVINDNISDNLKRQINMVTETITVRETLSSEIYSVNQTEHKLMYQATQLLLDYIHHTQKRDLSHIEDVVQYAAIDYMKMDFYAKRNLELTESIRLKSKKGTLLWLMDETKTPMGARRLKQWIDRPLISKEQIEARLDIVDEFSAHFIERDTLRTYLNQVYDIERLVGRVSYGNVNARDLIQLKHSISEIPNIKALLNSMNQNTLVQVNQLEPLDDLLDILEQSLVEEPPISVKDGGLFKVGFNTQLDEYLEASKNGKTWLAELQAKERQRTGIKSLKISFNKVFGYFIEITRANLQNFEPSEFGYMRKQTLSNAERFITDELKEKEDIILGAEDKAIELEYQLFVQLREEVKKYTERLQQQAKIISELDCLQSFAEIAQKYNYTRPSFSENKTLELVESRHPVVERVMDYNDYVPNNCRLDNETFIYLITGPNMSGKSTYMRQVAIISIMAQMGAYVPCKEAVLPIFDQIFTRIGAADDLVSGKSTFMVEMLEAQKALTYATEDSLIIFDEIGRGTSTYDGLALAQAMIEYVAETSHAKTLFSTHYHELTTLDQALPSLKNVHVAANEYKGELIFLHKVKDGAVDDSYGIQVAKLADLPEKVISRAQVILSEFEASAGKKSSISNLKMVENEPEINQENLNLSVEETTDTLSQKDFEQASFDLFENDQESEIELQIKNLNLSNMTPIEALVKLSELQNQLK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: AROE_NEIG1
Sequence: MHALPRYAVFGNPAAHSKSPQIHQQFALQEGVDIEYGRICADIGGFAQAVSTFFETGGCGANVTVPFKQEAFHLADEHSDRALAAGAVNTLVWLEDGRIRGDNTDGIGLANDITQVKNIAIEGKTILLLGAGGAVRGVIPVLKEHRPARIVIANRTRAKAEELARLFGIEAVPMADVNGGFDIIINGTSGGLSGQLPAVSPKIFRDCRLAYDMVYGEAAKPFLDFARQSGAKKTADGLGMLVGQAAASYALWRGFKPDIRPVIEHMKAL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: CLPX_CLONN
Sequence: MSKYDDKKQLKCSFCGKSQEQVKRLIAGPGVYICDECIDLCSEIITDEFEENTQVDLSSLPKPSEIKNYLDDYVIGQDSAKKALAVAVYNHYKRINSDVDVDDVELQKSNILLLGPTGSGKTLLAQTLARLLNVPFAMADATTLTEAGYVGEDVENILLKLIQNADYDIEKAERGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQINTSNILFICGGAFDGLDKIIEKRTRKSSLGFGSTVQSKEEKDIGELLKESVPEDLLKFGLIPEFIGRLPIMVTLQSLDNSALVRILKEPKNALVKQYKKLLLMDNVELEFEDEALKAIADEAIERKTGARGLRSIIEETMRDIMFDIPSQFNIKKVIINKDTIKNKKPELVLTEDGEDRPEIVQTKHKRKSMDPETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RRF_SACD2
Sequence: MIDDIKSDSEERMSRAIEALGTHFNKIRTGRAHPSILDGVMVSYYGSATPLSQVANVTVLDARTLSISPWEKNIVPEIEKAIMKSDLGLNPVTTGDLIRVPMPMLTEETRKGYIKRARAEAESARVSIRNVRRDALAEVKALVKDKEISEDDERRAADEIQQITNKYVAEVDKALSAKEKDLMEI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBD16_ARATH
Sequence: MDNINGLPDDLLVKILSFVPTYVAVSTCVLSKRWEFLWMWLPNLEFVSPWDSRPGIVDFINKKLPIHRAPVIERLCIHINSNPHIKPEYIKRWIEIAVSHYVRELQIDYHSKTKITLQLEAESYFIDGKYLQQLISGCPVLEDLSLRFCCNDNLREFTVIIPSLQSLSLFLFGNSNLNRYKIDTPSLKYLKLEDWNDPEHYSWTNMPKLREAYVDVESSNHLKTLIGSITSVKHLTICCLEDYLYGDGFIFNHLEHLKLCMCPFDSSNLLGQLLKGSPNLQVLDIFEMKRNDIVCWNQPSSVLECLLSSLKILNWSAYFGRPQDRDIAVYILKNACHLKTATFLTDKRINDVRRLKMIKELRLSPRASSTCQLVFGEDF
What are the official names of this protein?
Putative FBD-associated F-box protein At5g38570.
Protein: SNF5_XENLA
Sequence: MIMALSKTFGQKPVKFQLEEDGDYYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVASSHGKKYHGHTTLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPTYLREQKAKRNSQWVPTLPNSSHHLDAVPCSTTINRNRMGRDKKRTFPLCFDDHDPAVIHENAAQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFAEILCDDLDLNPLAFVPAIASAIRQQIESYPTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIRGQLSWHQKTYAFSENPLPTVEIAIRNTGDADQWCPLLETLTDAEMEKKIRDQDRNTRRMRRLANTAPAW
What is the function of this protein?
Involved in chromatin-remodeling.  Core component of the BAF (SWI/SNF) complex.  This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation.  Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity).
What are the official names of this protein?
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1.
What is the protein family that this protein belongs to?
Belongs to the SNF5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UVRC_MYCSS
Sequence: MPDPSTYRPAPGSIPVEPGVYRFRDPHGRVIYVGKAKSLRSRLNSYFADLSGLAPRTRQMVMTAAKVEWTVVNTEVEALQLEYNWIKEFDPRFNIRYRDDKSYPVLAVTLNEEFPRLKVYRGPRKKGVRYFGPYSHAWAIRETVDLLTRVFPARTCSAGVFKRHNQIDRPCLLGYIDKCSAPCVGRVSAEQHRQIVLDFCDFLAGKTDRLVRDLERKMTAAAEDLDFERAARLRDDIGALRRALEKQTVVFGDGTDADVVAFADDDLEAAVQVFHVRGGRVRGQRGWIVEKSGEPGESGEGQLVEQFLTQFYGDQAELGSAGDNAGDSGQDEATNPVPRQVLVPCLPDNADELTEWLSQLRGSRVALRVPQRGDKKALFETVQRNAKEALAQHKLKRAGDFTARTAALQSIQDTLGLADAPLRIECIDISHVQGTDVVASLVVFEDGLPRKSDYRHYAIREAAGDGRSDDVASIAEVTRRRFYRHLHDTQHPTELSAEGKSRKFAYPPNLFVVDGGAPQVNAAQAVLDELGISDVAVIGLAKRLEEVWVPSGSDLGPEPIILPRNSEGLYLLQRVRDEAHRFAITYHRSKRSKRMTASALDSVRGLGEHRRKALVTHFGSVARLKEASVEEITAVPGIGVTTARAVLEALGVPQAAPADSDTAAAVIDDDQRRVTG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_ACAM1
Sequence: MSRPSILVLHGPNLNLLGQREPGIYGSVTLEKINQQLLSLAESLKCNIEFYQSNHEGNLVDSIQEALGCHNGILINAAAYTHTSVAIRDALAAVAIPAVEVHLSNIYRREDFRHHSFIAPIVIGQISGFGAQSYSLGLQALIHHLQTQT
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: NILP1_ARATH
Sequence: METEGRRREVVVSSLQFACSDDISTNVAAAERLVREAHAKGANIILIQELFEGYYFCQAQREDFFKRAKPYKNHPTIARMQKLAKELGVVIPVSFFEEANTAHYNSIAIIDADGTDLGIYRKSHIPDGPGYQEKFYFNPGDTGFKVFQTKFAKIGVAICWDQWFPEAARAMVLQGAEILFYPTAIGSEPQDQGLDSRDHWRRVMQGHAGANVVPLVASNRIGKEIIETEHGPSQITFYGTSFIAGPTGEIVAEADDKSEAVLVAQFDLDMIKSKRQSWGVFRDRRPDLYKVLLTMDGNL
What is the function of this protein?
Involved in polyamine biosynthesis (PubMed:12435743).  Catalyzes the hydrolysis of N-carbamoylputrescine to produce putrescine and ammonia (PubMed:12435743).
What are the official names of this protein?
N-carbamoylputrescine amidase, Nitrilase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily.
Protein: COBT_PHOPR
Sequence: MFTITQPDTQPSDHIQHKIDNKTKPLGALGQLEAVALQLALIQQTEKIEIRHPHLLVFAGDHGIAQHSLSIAPSEVTAQMVANFLAGGAAINCFCRTNDMALKVIDAGIKVEPEDHPNLIKQRLGHGTEDFSQYAAMTDNTVLQALEYGANVVEVLNQQSCNLVGFGEMGIGNTSSAAAIMAALLNIPADECVGRGTGIDDQQLQRKVDLITQALDLHAEQLSDPLSILASVGGFEIAQIVGGMLKAAENKMTVLVDGFISTAAAMLAVSMHPEANHYFIYCHCSDESGHQRMLQHLNATPLLSLGLRLGEGTGAALALPLLRSACCFYNEMASFEDAGVTV
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RS16_SHEB5
Sequence: MVTIRLARGGAKKRPFYNIVVADSRNARDGRFIERVGFFNPLARGQEETLRLDLARVEHWVSNGAAATERVAKLIKDARKATA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SART_STAAM
Sequence: MNDLKSKSNIKLMKRVLTTYELRKYLKKYFCLTLDNYLVLAYLDVFKNDEGKYFMRDIISYIGIDQSRIVKSVKELSKKGYLNKCRDPHDSRNVIIVVSVKQHNYIKNLLSEININET
What is the function of this protein?
Transcriptional regulator acting as an intermediary between major regulators SarA and agr and virulence genes.  Represses alpha-hemolysin (hla) gene expression (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator SarT, Staphylococcal accessory regulator T.
What is the protein family that this protein belongs to?
Belongs to the SarA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTSS1_CHICK
Sequence: MAACVGSRTLSKDDVNYRLHFRMINEQQVEDITLEFFYRPHTITLLSFTILSLMAFAFTRDDSVPEENIWRGILSVIFFFLIISVLAFPNGPFTRPHPAIWRMVFGLSVLYFLFLVFVLFLNFEQVKAVMYWLDPNLRYATREADIMEYAVNCHVITWERILSHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGIYLFMIIWQLTELNTFFLKHIFVFQASHPLSWGRILFIGIITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIAFLEAIVCIKFGQDLFSKTQILYVVFWLLCVAFTTFLCLYGMVWYAEYYGHREKTLSESEDSPYSPDASWLHSKFSKGADNSPPKHPVNSESHSSRRRNRHSRSKVTNGIGKK
What is the function of this protein?
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity).  Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
What are the official names of this protein?
Phosphatidylserine synthase 1, PSS-1, PtdSer synthase 1, Serine-exchange enzyme I.
What is the protein family that this protein belongs to?
Belongs to the phosphatidyl serine synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Protein: ISPE_NEIM0
Sequence: MNIADGRQAFPAPAKLNLDLRITGRREDGYHNIESIFCLIDLQDTVYLKPRDDGKIILHNPVGGIPQEADLSYRAASLLQKYARNPAGVEIWLDKKIPTGAGLGGGSSDAATVLLVLNRWWQCSRTTQQLIDLGATLGADVPFFIFGKNAFASGIGEKLIGMDIPKQWYVIVKPPVHVSTAKIFTHEGLTRNSASSIMPTFQNLQPFRNDMQAVVFKEYPEVWKAYSELSRYGFALMTGSGACVFTACQDRDSAYNIYRQVSGLYEAYLAEGLSKHPLLSV
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: IF2_MYCPN
Sequence: MSKHKPRHFQKNKFDNRAKTSAKQQFRQVKTGVKDGVFVYKGPLTVSEFCLKTNIPTANIIKHFFLNGVPLTLNSVLSTEQLADACVNFGFDFKVETEITHDNIISNIKFDDDPTQLSPRPPIVTIMGHVDHGKTSLLDAIRQTNTAAKEFGGITQKIGAYQVKNQEGKTITFIDTPGHEAFTGMRARGAQVTDIVVLVVAGDDGLKQQTEEAISHAKSAKTPIIVFINKMDKPTANPDMVIQQLNKFDLVPEEWGGDTIFVKGSALTKEGIQELLDSILLVAEVEDYKANFNAHSSGYAIEVQTTKGLGPTATIIVKRGTLKIGDIVVLGPAWGKVRTMQDENGVHLQEAMPSKPVQISGFDIVPVAGEKFIVFDDEKDAKLIANKFREQQKQKLNTTQINEELKQKIKSKEIKVLNLIFKVDSDGSLAAIKQAMQSIDVPGMSVNIIHSGVGLISENDIMLAKASGALLFSLNLGLSQVVKNIASLQGVKVDVHYHIPKLAEEIENILKGQLEPVYEDVELGRAEVLQLWYHSKVGHIAGTLVKTGKVKRGALCKLLRRNETIYEGRVDSLKSEKNPVNQMEAGKNCGIVINGCEDIQVCDIILVYEKQEVKSKS
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMG_DROER
Sequence: MKYATGTDNAMTSGISGQTNNSNSASTEMQPTTSTPTAVHKEATPTATTTATYANGNPNPNANPSQSQPSNALFCEQVTTVTNLFEKWNDCERTVVMYALLKRLRYPSLKFLQYSIDSNLTQNLGTSQTNLSSVVIDINANNPVYLQNLLNAYKTFQPCDLLDAMSSSSSDKDSMPCYGSDFQITTSAQCDERKLYARKEDILHEVLNMLPLLKPGNEEAKLIYLTLIPVAVKDTMQQIVPTELVQQIFSYLLIHPAITSEDRRALNIWLRHLEDHIQAAAAGLTNRSYFLQPSPQLVAGGSSTGSGSCSSSATSSSTASCSSVASSSLCPASGSRSSRTNDWQTIAPPSKQLQNKLAGDWRGSGGGSSSGSINPLCDNLNGITLNELASSQNSLGLSLEGSSSLVNGVVAGAGSMLGIGGGDDHDTSFSKNGTEILDFDPVTADMGEACSLASSSLCGRNGGNPVEDRSQPPPNLQQQMLQPPPYASILMGNVGDQFGEINRWSLDSKIAALKTRRSNSLTTQTISSCSSSSNSSVITVNDNCSNSTENLAQFANKPRSFSLSIEHQRGALINSGSDTRLDEFKPNYIKFHTRNVGMSGIGLWLKSLRLHKYIELFKNMTYEEMLLITEDFLQSVGVTKGASHKLALCIEKLKERANILNRVEQELLTGQMELSTAVEELTNIVLTPMKPLESPGPPEENIGLRFLKVIDIVTNTLQQDPYAAQDDETLGVLMWILDRSIHNEAFMNHASQLKDLKFKLSKMKISMVPKMHHVKPAGVGPNNGNINKPRWNGKTRKCDPKNGSNDRINNRKNSNDMLNFSLNCLPHPLPHHSQQPPPPLPQFDYNGYGGGPSHQPQYKSSSYPSFMGNPQQQPPPPPPTKSHHHAQQMQQMLQQHNHFPALPQQTPPQSHRRSLNNLILVAGGPQQPQQLIFKPGQGVLTNNGSSDNLGLERNQQPQQQQRKLSGGVTSAEQQPKKTMAAVVMENLAKFDQHFTLF
What is the function of this protein?
Translation regulator that binds to the 3'-UTR of specific mRNAs such as nanos (nos) and prevent their translation.  Prevents translation of unlocalized nos in the bulk cytoplasm via the recruitment of cup (By similarity).
What are the official names of this protein?
Protein Smaug.
What is the protein family that this protein belongs to?
Belongs to the SMAUG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFL1_ARATH
Sequence: MGGCVSVSLSCDREVNQFSQWLCVSGSYIQNLSENLASLQKAMGVLNAKRDDVQGRINREEFTGHRRRLAQVQVWLTRIQTIENQFNDLLSTCNAEIQRLCLCGFCSKNVKMSYLYGKRVIVLLREVEGLSSQGVFDIVTEAAPIAEVEELPIQSTIVGQDSMLDKVWNCLMEDKVWIVGLYGMGGVGKTTLLTQINNKFSKLGGGFDVVIWVVVSKNATVHKIQKSIGEKLGLVGKNWDEKNKNQRALDIHNVLRRKKFVLLLDDIWEKVELKVIGVPYPSGENGCKVAFTTHSKEVCGRMGVDNPMEISCLDTGNAWDLLKKKVGENTLGSHPDIPQLARKVSEKCCGLPLALNVIGETMSFKRTIQEWRHATEVLTSATDFSGMEDEILPILKYSYDSLNGEDAKSCFLYCSLFPEDFEIRKEMLIEYWICEGFIKEKQGREKAFNQGYDILGTLVRSSLLLEGAKDKDVVSMHDMVREMALWIFSDLGKHKERCIVQAGIGLDELPEVENWRAVKRMSLMNNNFEKILGSPECVELITLFLQNNYKLVDISMEFFRCMPSLAVLDLSENHSLSELPEEISELVSLQYLDLSGTYIERLPHGLHELRKLVHLKLERTRRLESISGISYLSSLRTLRLRDSKTTLDTGLMKELQLLEHLELITTDISSGLVGELFCYPRVGRCIQHIYIRDHWERPEESVGVLVLPAIHNLCYISIWNCWMWEIMIEKTPWKKNLTNPNFSNLSNVRIEGCDGLKDLTWLLFAPNLINLRVWGCKHLEDIISKEKAASVLEKEILPFQKLECLNLYQLSELKSIYWNALPFQRLRCLDILNNCPKLRKLPLDSKSVVKVEEFVIKYKEKKWIERVEWEDEATQYRFLPTCRLR
What is the function of this protein?
Disease resistance (R) protein.
What are the official names of this protein?
Disease resistance protein RFL1, RPS5-like protein 1, pNd13/pNd14.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
Protein: SSRP_STRT1
Sequence: MPKGEGNVVAQNKKARHDYSIVDTIEAGIVLTGTEIKSVRAARIQLKDGYAQIKNGEAWLINVHIAPFEQGNIWNQDPERTRKLLLKKKQITKLQNDLKGTGMTLVPLKVYLKNGFAKVLLGIAKGKHDYDKRESIKRREQERDIKRIIKSVNR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: GUAC_OENOB
Sequence: MEVFDYENVQLIPNKCLISSRSEADTSVEFGGHRFKLPVVPANMASVIDDKLAIWLAENGYFYIMHRFEPGKRFNFVTDMKQRGLISSISVGVKEEEYRLIDELVDAGLTPDYITIDIAHGYANTVIDMIHYIKKHLPKAFVVAGNIATPDAVRELEDAGADATKVGIGPGRACITKLKTGFGTAGWQLAAVRLCAKAARKPIIADGGIRHNGDIAKSVRFGASMVMIGSLFAGHKQSPGSDLVIDHRHYKQYYGSASAKQKGVYKNVEGKDLLVPYRGDIANTLNEMAQDLQSSISYAGGNNLQALRTVNYVIVQNTIMNGD
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: PFF1_SCHCM
Sequence: MGIVDYLVAAVSFRTLPTTFVAVLVYLAIFISVLITDELPATPKDQRGLNLTQAYSDLRQIAARPHPYNSHANDVVHDFILTRLQDATAGYDYAHVFDDKVSNGSWSSRNNSVYFEGTNILVKVDGHDADKSGALFSAHYDSVSTAPGATDDGMGVATLLQLVEYYVKHRPQRTAVFNINNGEEDWLNGAHAFLEHPWSNLTDTFLNLEGASSGGRPLLFRATATAPVRAFREKYVTHPHGNVLSSDAFARGVVRSGTDYSVYVDGRGMDGADLAFYKGRSRYHTRYDAVQYTDGGVRSLWAMMEAAQGVSGALLSSEAVHGDKGGAPVYFDLFGQALIVFPLSAMITFNIVFLVVGPIMLALLVTFDIVARHRRQEMIGGGYEEQGFFARAWTSFKSFRWVGGFWKHAKFWVALAVTVGLQVLLCVGYLYINPLIAYSSSHIVLLSFLSLAYLSTYLVHNIPSPTDTYGSHLPEQQKQAALFQLYFFTWILLLAATVVGAKLSVGSFYILSLWNAVLFAACAIGSIAGLLSSHTVEGDASYGSRRRIRGVRYDREGEEEGVESETAPTEVTPLIAQPITVVAPGGKEGEEVSGAIGWWFVQFVLSVPAVVILVSQLALLMLAATEQTLADGSPAVTVYGGASLMSVLAILPLAPFACKLHRRVAYVALVVLIASTAYAWLVFPFSERAPLKVFFQQQVDLDANITETRITGHPAYLRQAIAALPSAGGAPLNCTADDAKAGLQTCGWTPPPALEPSVIALDFNVSRSEGQNQARFEIAETDTRACRVYFDQAVTRFQVHGGTEGVQKGFEIPEEGVRELRLWSRTWDRTWVVDVDREGSALTGRVACEWSEYASGSLGVETRTRIPAYEEVLTFLPSWAVASKFADGLVEGYKAFAV
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: SURE_LEGPA
Sequence: MKILVSNDDGVLAPGIKILANELSTLGEVKVVAPDRNRSGASNSLTLTQPLRVKQLDNGYYSVDGTPTDCVHLALTGFLEPIADIVVSGINEGANLGDDVLYSGTVAAAMEGRYLGLPAIAISMVGDNIQYYETAAIIAKQLVIKLSANKLPSQTILNVNVPDLPLSQIRGLQVTRLGTRHSAEPIIKEYDPRGRPIYWVGPPGIEADAGAGTDFFAIKTGHVSITPLHLDMTHYKLFDHLSNLLNEICIEN
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFX6_HUMAN
Sequence: MAKVPELEDTFLQAQPAPQLSPGIQEDCCVQLLGKGLLVYPEETVYLAAEGQPGGEQGGGEKGEDPELPGAVKSEMHLNNGNFSSEEEDADNHDSKTKAADQYLSQKKTITQIVKDKKKQTQLTLQWLEENYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKESSAYYHSVYSGKGLTRFSGSKLKNEGGFTRKYSLSSKTGTLLPEFPSAQHLVYQGCISKDKVDTLIMMYKTHCQCILDNAINGNFEEIQHFLLHFWQGMPDHLLPLLENPVIIDIFCVCDSILYKVLTDVLIPATMQEMPESLLADIRNFAKNWEQWVVSSLENLPEALTDKKIPIVRRFVSSLKRQTSFLHLAQIARPALFDQHVVNSMVSDIERVDLNSIGSQALLTISGSTDTESGIYTEHDSITVFQELKDLLKKNATVEAFIEWLDTVVEQRVIKTSKQNGRSLKKRAQDFLLKWSFFGARVMHNLTLNNASSFGSFHLIRMLLDEYILLAMETQFNNDKEQELQNLLDKYMKNSDASKAAFTASPSSCFLANRNKGSMVSSDAVKNESHVETTYLPLPSSQPGGLGPALHQFPAGNTDNMPLTGQMELSQIAGHLMTPPISPAMASRGSVINQGPMAGRPPSVGPVLSAPSHCSTYPEPIYPTLPQANHDFYSTSSNYQTVFRAQPHSTSGLYPHHTEHGRCMAWTEQQLSRDFFSGSCAGSPYNSRPPSSYGPSLQAQDSHNMQFLNTGSFNFLSNTGAASCQGATLPPNSPNGYYGSNINYPESHRLGSMVNQHVSVISSIRSLPPYSDIHDPLNILDDSGRKQTSSFYTDTSSPVACRTPVLASSLQTPIPSSSSQCMYGTSNQYPAQETLDSHGTSSREMVSSLPPINTVFMGTAAGGT
What is the function of this protein?
Transcription factor required to direct islet cell differentiation during endocrine pancreas development.  Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100).  Not required for pancreatic PP (polypeptide-producing) cells differentiation.  Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice.  Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032).  Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).
What are the official names of this protein?
DNA-binding protein RFX6, Regulatory factor X 6, Regulatory factor X domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the RFX family.
What are the subcellular locations of this protein?
Nucleus.