PharMolix/UniProtQA huggingface dataset:
Protein: CMOM_ECO57
Sequence: MQDRNFDDIAEKFSRNIYGTTKGQLRQAILWQDLDRVLAEMGPQKLRVLDAGGGEGQTAIKMAERGHQVILCDLSAQMIDRAKQAAEAKGVSDNMQFIHCAAQDVASHLETPVDLILFHAVLEWVADPRSVLQTLWSVLRPGGVLSLMFYNAHGLLMHNMVAGNFDYVQAGMPKKKKRTLSPDYPRDPTQVYLWLEEAGWQIMGKTGVRVFHDYLREKHQQRDCYEALLELETRYCRQEPYITLGRYIHVTARKPQSKDKV
What is the function of this protein?
Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA 5-carboxymethoxyuridine methyltransferase, cmo5U methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
Protein: MSRP_SALPB
Sequence: MKKIRPLTEADVTAESAFFMQRRQVLKALGISAAALSLPSTAQADLFSWFKGNDRPKAPAGKPLEFSQPAAWRSDLALTPEDKVTGYNNFYEFGLDKADPAANAGSLKTEPWTLKISGEVAKPFTLDYDDLTHRFPLEERIYRMRCVEAWSMVVPWIGFPLYKLLAQAQPTSHAKYVAFETLYAPDDMPGQKDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPIRLIVPWKYGFKGIKSIVSIKLTRERPPTTWNLSAPNEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYANEVASLYRGLNLRENF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: RL32_ECO8A
Sequence: MAVQQNKPTRSKRGMRRSHDALTAVTSLSVDKTSGEKHLRHHITADGYYRGRKVIAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RNZ_CHLT2
Sequence: MSYRGLTILGCSSQQPTRHRNHGAYLLRWNGEGLLFDPGEGTQRQFIYANIAPTVVSRIFISHFHGDHCLGLGSMLMRLNLDRVSHPIHCYYPASGKKYFDRLRYSTIYHETIKVIEHPIDREGIVEDFGNFRIESRQLDHLVDTLGWRITEPDTTKFIPEKIKAAGLKGPIMQELINKGRVKVNDTIVHLDDVSYTRKGDSIAVVADSLPCQAIVDLARNARILLCESTYLEEHSHLAKSHYHMTAKQAAEQAKRAEVQQLILTHFSARYNTTEEFVQEAGEIFPNVFAAEEFCSYEFPKNPS
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: HCYB_CANPG
Sequence: ADLAHRQQSVNRLLYKIYSPISSAYAELKQLSTDNXD
What is the function of this protein?
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
What are the official names of this protein?
Hemocyanin subunit B.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family. Hemocyanin subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: TMM8B_BOVIN
Sequence: MNMPQSLGNQPLPPEPPSLRTPAEGPGATSPPEHCWPVRPTLRNELDTFSVHFYIFFGPSVALPPERPAVFALRLLPVLDSGGVLSLELQLNVSSLRQENVTVFGCLTHEVPLSLGDAAVTCSKESLAGFLLTVSAASRVARLRIPFPQTGTWFLTLRSLCGVGPRFVRCRNATAEVRLRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFCLCPGSLIAGSAILLYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDRRVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS
What is the function of this protein?
May function as a regulator of the EGFR pathway.  Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity).
What are the official names of this protein?
Transmembrane protein 8B, Protein NGX6.
What is the protein family that this protein belongs to?
Belongs to the TMEM8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic reticulum.
Protein: SYR_SULTO
Sequence: MNPIKEVKLEFAKILSERLSIDQNKIYENFEYPPKEQMGDVSLPLPTVTKNKELLNISDFPSGGKLIREIKKAGIYINGVINESELFKLIFTNFPEDYGIEKIQKPQRVVVEHTSANPIHPLHVGHLRNAILGDVIARMLKARGHEVNTRFYVNDAGRQVAILTLGYLLLGEPNPPRDEKIDQWIGVIYAITNILIEINQLKKELSSSNEEEYRQKISKLDELISLAGKHREKYPEIFDKLADEISKIENIEEKIQNIIKNYERHSDEKIVNVIRKLVNWTLEGFKDSLKILDIHFDNFDYESDLLWSKRVDEIVKLALSSKNIKEHKGTIALSLDLDPEARKRLNIPLGLELPPLVLVRSDGTTLYTTRDIAYSLYKFEVFYANKVINVIAEQQSVPQMQLRASLYLLGFKDIAENLIHYSYGMVNLQGMRMSGRLGRYISLDEIINEVKEVAENKIKEKGGDLNNLLDIVNSAIRYAILSVSANKPVSFNIKNIVDFDQNSGPYLQYTYARAYNILAKNEEKLDINKVDFSDIVDDKRRLLISIAKFPEVATKAVDELRPEDLLGFMRSIADIFNRWYNFERVLQEPNEGKRMLRLFIVKGVERILYNGLSIVGIKPLKRM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_PSEF5
Sequence: MENLDALVSQALEAVQHAEDINALEQIRVHFLGKKGELTQVMKTLGNLPAEERPQVGALINVAKERVTEVLNARKAAFEEAELSAKLAAECIDVTLPGRGQTSGGLHPITRTLERIEQFFTHIGYGIAEGPEVEDDYHNFEALNIPGHHPARSMHDTFYFNANMLLRTHTSPVQVRTMESQQPPIRIVCPGRVYRSDSDITHSPMFHQVEGLLVDRDINFADLKGTIEEFLRVFFEKELAVRFRPSYFPFTEPSAEVDMECVMCSGKGCRVCKQTGWLEVMGCGMVHPNVLRMSGIDPEEFQGFAFGMGAERLAMLRYGVNDLRLFFDNDLRFLAQFR
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHT11_ARATH
Sequence: MAEQQLGVLKALDVAKTQLYHFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYYFNPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLVMMILCSVASGLSFGHEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALAVSSIFDKKFPAPTYAVNRALSTPPQVDYIWRIIVMFGALPAALTYYWRMKMPETARYTALVAKNIKQATADMSKVLQTDIELEERVEDDVKDPKQNYGLFSKEFLRRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIPKAATMNATHEVFRIARAQTLIALCSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWIKPENRIGFVVMYSLTFFFANFGPNATTFIVPAEIFPARLRSTCHGISAAAGKAGAIVGAFGFLYAAQSQDKAKVDAGYPPGIGVKNSLIMLGVLNFIGMLFTFLVPEPKGKSLEELSGEAEVSHDEK
What is the function of this protein?
High-affinity transporter for external inorganic phosphate.  Acts as a H(+):phosphate symporter in both low- and high-Pi conditions.  Confers sensitivity to arsenate.
What are the official names of this protein?
Inorganic phosphate transporter 1-1, AtPht1;1, H(+)/Pi cotransporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. phosphate:H(+) symporter (TC 2.A.1.9) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRPF_GRABC
Sequence: MVAQVKICGLNSAASVAASIAGGADYLGFVFFPPSPRAVTAQEAASLAAPIAQPLRKVGLFVNPRDGEIEAVLRELPLDIIQLHDVPVARALQLRERLALPVWRSVGIAAADDLPRDSGGVDALLLDAKPRPDAALPGGNGQAFDWSILADFAPSFAWILAGGLTPDTVADAVRRTGAPIVDVSSGVEQSRGRKDPALIRSFLSAVRNA
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: YBEY_YERPP
Sequence: MSQVILDLQIACADSQGLPTEGDFQRWLEAVLPLFQPVSEVTIRLVDEAESHDLNLTYRGKDKSTNVLSFPFEAPPEIELPLLGDLIICRQVVEKEAIEQEKALLAHWAHMVVHGSLHLLGYDHIDDEEAEEMELIETEIMHGLGYPDPYISEKDPD
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMC_SHEAM
Sequence: MLSNPSELVTRNIEQLENQRVMLINIEADELGHHLTRHCSEVAALALDFNHFQAQPSGKSGFRCEFGHQWSRDEKFDVVVVYFPKAKALAPYLFALAAWHLRPDGTLLITGENKGGIRSVDKLLGNAFSPACKIDNARHCLLYSATLVAEATKPNAEDWVSRYRLSLPSGDIQICNMVGVFSDKQLDQGTALLLDNLPKLEGRVLDFGCGAGVIAIALMQQNPGLQLECVDINAMALLSCELSLKANGMEAKVYASDGLAQTDGLFNAIVSNPPFHDGLSSTTDIATRFVADSYKQLHKGGNWQIVANRHLPYSDTIAKVFGEVNTVAENNKYKVYANKKR
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_PHEZH
Sequence: MTKAASGDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREEHKISFVKSKDGVPTPKEIREVLDDYVIGQDHAKKVLSVAVHNHYKRLNHATKNNDVELGKANILLIGPTGTGKTLLAQTLARIIDVPFTVADATTLTEAGYVGEDVENIILKLLQAADYNVERAQRGIVYIDEVDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLEKIISARGQGTSIGFGAKVADPDERRTGEIFRQVEPDDLLRFGLIPEFIGRLPVIATLDDLDEKALVKILTEPKNAFVKQYVRLFEMENVGLTFTEDALMAVARKAIQRKTGARGLRSILEGVLLDTMYELPTYDGVEEVVVNAEVIEGRAQPLIIYAERRDKGGAA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: MEPA_ECODH
Sequence: MNKTAIALLALLASSASLAATPWQKITQPVPGSAQSIGSFSNGCIVGADTLPIQSEHYQVMRTDQRRYFGHPDLVMFIQRLSSQVSNLGMGTVLIGDMGMPAGGRFNGGHASHQTGLDVDIFLQLPKTRWTSAQLLRPQALDLVSRDGKHVVSTLWKPEIFSLIKLAAQDKDVTRIFVNPAIKQQLCLDAGTDRDWLRKVRPWFQHRAHMHVRLRCPADSLECEDQPLPPSGDGCGAELQSWFEPPKPGTTKPEKKTPPPLPPSCQALLDEHVI
What is the function of this protein?
Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands.  Likely plays a role in the removal of murein from the sacculus.
What are the official names of this protein?
Penicillin-insensitive murein endopeptidase, D-alanyl-D-alanine-endopeptidase, DD-endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M74 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MORC1_MOUSE
Sequence: MDKYALLQRAKLHLDFIHANSTTHSFLFGALAELLDNARDAGAVRLDVFSVDNETLQGGFMLCFLDDGCGMSPDEASDVIYFGTSKKRLSTLKFIGQYGNGLKSGSMRIGKDCILFTKKEETMTCLFFSQTFCEKEGLTEVVVPIPSWLTRTRESITDDPQKFFTELSIIFKYSPFKTEAELMQQFDMIYGRCGTLLIIYNLKLLLSGEPELDVTTDKEDILMAEAPEEIPERRSFRAYTAVLYFEPRMKIFIQAKRVQTKHLCYSLYKPRKYQYTTSSFKGKFKTEVQKAEEAVKRAELLFKEVQAKVNQPDRIALSSTQDALQKALQDVDTKHKSLRQKQRALRKARTLSLFFGVNTEDQHQAGMFIYSNNRLIKMYEKVGPQLKMKSLLGAGIIGIVNIPLETMEPSHNKQEFLNVQEYNHLLKVMGQYLIQYCKDIGISNRNLTLFWDEFKYQHSKDTDSSLESLQWRRRQAMGIPFILQCDLCLKWRVLPSSSNYQEKGLPDLWICASNPNNLENSCNQIERLPSIPLGTVNRRPPSKDERERQLQESVQRYQDKLVEAQPQKSQLIVTSKIPEFKSSCLSSALKEKSKLGRIQPSGADLTQGSPSSVKLSFMQRSQKRSTEDTHSDVEFICMTKIPKKSVKKTVKYLQPGHAPALLENLKLEDTAQVSSREIKKQQSESLVQAGKASTDVASSRDPTVTMVWDQSSTKVSLKQEEEEEVPLIKPDKQELCDDTPVVKGNSSALHWKSLPGVQMEDLSPRSGHKINSVSGDCQLPASPMPSQSMSVEETARKLLSNLREILLYFVPEFQLSSEFECTSVEELITNPELERCPENINEKLKTCFNQIQNIYMAQYEKRLKRKMQSIVYEANRRGLLNQVFLGQCELKRKRTEEKLSDLRAKLALLLQKLQLGGPAGDPQQIDAYLEDLLKEDRLPTALHEKSPESA
What is the function of this protein?
Required for spermatogenesis (PubMed:10369865, PubMed:25503965).  Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (PubMed:25503965).  Not required for piRNA biosynthesis (PubMed:25503965).
What are the official names of this protein?
MORC family CW-type zinc finger protein 1, Protein microrchidia.
What are the subcellular locations of this protein?
Nucleus.
Protein: CTR2_DANRE
Sequence: MLEHCLTFGRSLVRRKNVDQGCLEESKLCRCLSTVDLIALGVGSTLGAGVYVLAGEVAKGSSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDEIIGGHIEKFCKMYFKMSLPGLAEYPDFFAVCLILLLSGLLSFGVKESAWVNKIFTAVNVLVLMFVIISGFVKGDSLNWNISEESLVNITVVKRNISSAANVTSDYGAGGFFPYGFGGTLAGAATCFYAFVGFDCIATTGEEVKNPQRAIPIGIVVSLLVCFLAYFGVSAALTLMMPYYLLDEKSPLPLAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGVLFRFLSKLSKRQSPVAATMAAGTTAAIMAFLFDLKALVDMMSIGTLLAYSLVAACVLILRYQPDASFERSRISEGKEEVGESELTESESHLNMLKDGGVTLRSLLHPPLLPTENTSSVVNVSVIITVLVVCVVSTLNTYYGQAIIAMELWALGVLAASLFIFIICVFLICRQPQTRKKVSFMVPLLPFLPILSIFVNVYLMVQLSGDTWIRFSIWMAIGFLIYFGYGMWHSDERKRHLQNCAVATEKKTLTGNEGFVENKTHTEKTSPC
What is the function of this protein?
Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
What are the official names of this protein?
Cationic amino acid transporter 2, CAT-2, CAT2, Low affinity cationic amino acid transporter 2, Solute carrier family 7 member 2.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDXA2_CLOBH
Sequence: MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNINSIKKADEGKFTLGTIDLIDLNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELDAIATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEVRGMRVFFLTRHVSLRKACDLVTKERVLDYIIRCSEALEKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQKMGYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTSVDHGTAFDIAGTGQASSVSMVEAIILAAKYSPKFKK
What is the function of this protein?
Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).
What are the official names of this protein?
Putative D-threonate 4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family. PdxA2 subfamily.
Protein: WNK4_HUMAN
Sequence: MLASPATETTVLMSQTEADLALRPPPPLGTAGQPRLGPPPRRARRFSGKAEPRPRSSRLSRRSSVDLGLLSSWSLPASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPEPGPPPATVPMAPGPPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCETDGYLSSSGFLDASDPALQPPGGVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGLSDVGEGMGQMRRPPGRNLRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAPLPALPVPLPDPSNEELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSPSPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGLGAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSSRQRRLSKGSFPTSRRNSLQRSEPPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRM
What is the function of this protein?
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation.  Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively.  Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6.  Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3.  Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis.  WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis.  Phosphorylates NEDD4L.  Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase WNK4, Protein kinase lysine-deficient 4, Protein kinase with no lysine 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
What are the subcellular locations of this protein?
Cell junction, tight junction. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex.
Protein: RS11_SINFN
Sequence: MAKEATRVRRRERKNITSGVAHVNSSFNNTMITITDAQGNAIAWSSAGAKGFKGSRKSTPFAAQIAAEDCAKKAQEHGMKSLEVEVCGPGSGRESALRALQAAGFMITSIRDVTPIPHNGCRPRKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RS8_ACIAC
Sequence: MSMSDPIADLLTRIRNAQMVSKATVSVPSSKVKIAIAQVLKDEGYIDGFEVKSEGNKSELEISLKYYAGRPVIERIERVSRPGLRVYKGRDSIPQVMNGLGVAIVTTPKGVMTDRKARATGVGGEVLCYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: KLHDB_DROPE
Sequence: MGDLPGSTGGGSGPAAAGNASGNSSSAGNTGLGVAGTTGVDRPPSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRQNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVMRAPQTENYMWCENSLKQHNNPPS
What is the function of this protein?
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  May have a role in synapse differentiation and growth (By similarity).
What are the official names of this protein?
Kelch-like protein diablo.
Protein: RS19_SALA4
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPLRTWSRRSTIFPNMIGLTIAVHNGRQHVPVFVSDEMVGHKLGEFAPTRTYRGHAADKKAKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: S35A3_BOVIN
Sequence: MSANLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAELLKIMACILLVYKDSKCSLRALNRILHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLSKKLGVYQWLSLVILMTGVAFVQWPSDSQELNSKELSAGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYVYDGELVSKNGFFQGYNRLTWIVVVLQALGGLVIAAVIKYADNILKGFATSLSIILSTLISYFWLQDFVPTSVFFLGAILVITATFLYGYDPKPAGNPTKA
What is the function of this protein?
Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP (By similarity).  May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (PubMed:16344554).  However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (By similarity).
What are the official names of this protein?
UDP-N-acetylglucosamine transporter, Golgi UDP-GlcNAc transporter, Solute carrier family 35 member A3.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: RLA0_YEAST
Sequence: MGGIREKKAEYFAKLREYLEEYKSLFVVGVDNVSSQQMHEVRKELRGRAVVLMGKNTMVRRAIRGFLSDLPDFEKLLPFVKGNVGFVFTNEPLTEIKNVIVSNRVAAPARAGAVAPEDIWVRAVNTGMEPGKTSFFQALGVPTKIARGTIEIVSDVKVVDAGNKVGQSEASLLNLLNISPFTFGLTVVQVYDNGQVFPSSILDITDEELVSHFVSAVSTIASISLAIGYPTLPSVGHTLINNYKDLLAVAIAASYHYPEIEDLVDRIENPEKYAAAAPAATSAASGDAAPAEEAAAEEEEESDDDMGFGLFD
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.
What are the official names of this protein?
60S acidic ribosomal protein P0, A0, L10e, Large ribosomal subunit protein uL10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_ECOLU
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTDSIEKGLPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGKISRAQLQEIAQTKAADMTGADIEAMTRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.