PharMolix/UniProtQA huggingface dataset:
Protein: ENV_HV1S3
Sequence: MRARETRKNYQCLWRWGTMLLGMLMICSAAENLWVTVYYGVPVWKDATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLGNVTENFNMWKNNMVDQMHEDIVSLWDQSLKPCVKLTPLCVTLNCTDYLGNATNTNNSSGGTVEKEEIKNCSFNITTGIRDKVQKAYAYFYKLDVVPIDDDNTNTSYRLIHCNSSVITQTCPKVSFEPIPIHYCAPAGFAILKCNNKKFSGKGQCTNVSTVQCTHGIKPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTILVQLNVSVEINCTRPNNNRRRRITSGPGKVLYTTGEIIGDIRKAYCNISRAKWNKTLEQVATKLREQFGNKTIVFKQSSGGDPEIVMHSFNCRGEFFYCNTTKLFNSTWNENSTWNATGNDTITLPCRIKQIINMWQEVGKAMYAPPIEGQIRCSSNITGLLLTRDGGGDKNSTTEIFRPAGGNMKDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGVIGAMFLGFLGAAGSTMGAASITLTVQARKLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTTVPWNTSWSNKSLDKIWNNMTWMEWEREIDNYTSLIYTLLEESQNQQEKNEQELLELDKWASLWNWFSITNWLWYIRIFIMIVGGLIGLRIIFAVLSIVNRVRQGYSPLSFQTLIPAQRGPDRPEGIEEGGGERDRDRSTRLVNGFLALFWDDLRSLCLFSYHRLTDLLLIVARIVELLGRRGWEVLKYWWNLLLYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQRVGRAILHIPTRIRQGFERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: FB27_ARATH
Sequence: MNRGANSDSIPTDLIYEILSRLSVKPITRFRCVSKLWESIICRQDFTELFHNRSSSNPRLLIGVIQGGEWNFFSSPQPQNHYGKSSLVVAADSHMKFSEDKRPRYYSYASGLLYFPNIRISNHNDDVVRVICNPSTRQYAILPPDLRTRYRDSGRLFRNKLGVINLEDDYDGGYLLKLRMFVLEDFEKQKWTTYVHTLRDENKIKDNDNVYVVGATASGQIVLARNKAYKPFYVFYFNPEKSTLQSVEIQGVREEEDWFHRVYYFVDHVEDLRFDVMKTTYAATSIRPAEQNTSTSSREDHLVRTVKRKRA
What are the official names of this protein?
Putative F-box protein At1g31090.
Protein: AROA_BURL3
Sequence: MDYLDLGPYSSASGTVRLPGSKSISNRVLLLAALAEGETTITNLLDSDDTRVMLDALGTLGVKLARDGDTCVVTGTRGAFTAKTADLFLGNAGTAVRPLTAALAVNGGDYRVHGVPRMHERPIGDLVDGLRQIGAQIDYELNEGYPPLRIKPANISVDAPIRVRGDVSSQFLTALLMTLPLVKAKDGKIVVEVDGELISKPYIDITIRLMERFGVTVERDGWQRFVVPAGVRYRSPGRIMVEGDASSASYFLAAGALGGGPLRVEGVGRASIQGDVGFANALMQMGANVTMGDDWIDVRGIGHDHGKLEPIDMDFNLIPDAAMTIAVAALFANGTSTLRNIASWRVKETDRIAAMATELRKVGAIIEEGPDYLVVTPPEKLTPNAAIDTYDDHRMAMCFSLVSLGGVPVRINDPKCVGKTFPDYFDRFAALAKA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y748_RICPR
Sequence: MANIKHKLLIFLSFFCLLYLTSCQIHNEGEITIHKKEQKEIEIAILMPNQGPDAVVGKQYKDLIKMGLNDAVKSYIHVTSYDGSDEQNVLAAMDKIVARKTKIILGPLYSNFTSLITEKAKANDIIIITMSNNPALAEDKLFVFGHAPLKQLIRIINYYGDHHKDFMALLPQGKYSQTISQVMQNILIQKNSSLSHTEFYEDNPEAIEKAVRNISNNADIINERSDTTKPVIYLSDDPKNLNLLADSIRKYNLDKKAILIGDNRIDVDYSENIDISFTSTLNLFNSNVQDRAKDLGINHMGFMHLIAYDLGRMTANYIGNEFVSEIFLNRMHSRQPYIGLSGNIHFIDGVAQRRYDIIRKENGVYFTITED
What are the official names of this protein?
Uncharacterized protein RP748.
Protein: DNAA_FRATW
Sequence: MTTWDKCLKKIKKNLSTFEYKTWIKPIHVEQNSNLFTVYCNNEYFKKHIKSKYGNLILSTIQECHGNDLIIEYSNKKFSGEKITEVITAGPQANFFSTTSVEIKDESEDTKVVQEPKISKKSNSKDFSSSQELFGFDEAMLITAKEDEEYSFGLPLKEKYVFDSFVVGDANKIARAAAMQVSINPGKLHNPLFIYGGSGLGKTHLMQAIGNHAREVNPNAKIIYTNSEQFIKDYVNSIRLQDQDEFQRVYRSADILLIDDIQFIAGKEGTAQEFFHTFNALYENGKQIILTSDKYPNEIEGLEERLVSRFGYGLTVSVDMPDLETRIAILLKKAHDLGQKLPNETAAFIAENVRTNVRELEGALNRVLTTSKFNHKDPTIEVAQACLRDVIKIQEKKVKIDNIQKVVADFYRIRVKDLTSNQRSRNIARPRQIAMSLARELTSHSLPEIGNAFGGRDHTTVMHAVKAITKLRQSNTSISDDYELLLNKISR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_CLOB6
Sequence: MILVLDVGNTNIVLGIYKNKELIANWRLATDNKRTADEYGIQVIELFSHNNLSFSDIEGVIISSVVPNIMYSLEHMISKYFNIKPIIVGPGVKTGINIKYDNPKEVGADRIVNAVAAHEIYKKPLIIIDFGTATTFCAVTKEANYLGGTICPGIKISSDALFDKAAKLPRVELVKTPGVICKNTVASIQSGIIYGYAGQVDYIVSKMKKEMMDLGEEEPFVVATGGFAKLISEESKSIDEINAILTLEGLRVIYEKNK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGK_VIBCH
Sequence: MYYGFDVGGTKIEFGAFNEQLERVATERVATPTDDYAKLVETIAGLVHKYDAQFGVEGTVGLGIPGMEDADNGCVLTVNVPAAKGKPLRADLETKLGRAVKVENDANCFALSEAWDDELKEAASVMGLILGTGFGGGLVYEGKVFSGRNHVAGEIGHMRLPIDAWFHLGEKAPLLGCGCGNKGCMDNYLSGRGFELLYEHYYGEKKKAIDIITAQKEGESKAVEHVERFMELLAICFANIFTANDPHVVVLGGGLSNYDLIYEEMPKRVPKHLLSVAKCPKIVKAKHGDSGGVRGAAFLNIK
What is the function of this protein?
Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.
What are the official names of this protein?
N-acetyl-D-glucosamine kinase, GlcNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NagK subfamily.
Protein: RL14_BURM1
Sequence: MIQTESRLEVADNTGAREVMCIKVLGGSKRRYASIGDIIKVSVKEATPRGRVKKGEIYNAVVVRTAKGVRRQDGSLIKFDGNAAVLLNNKLEPIGTRIFGPVTRELRSERFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: NOP9_PARBD
Sequence: MPRDKQKRGRRAEAKRKRDDVITDPTVLKRQKSSDVCNYPNPSYEQLEIRGDYIPLDEEPVDYTGTPFYGLLDIEEQEYFSHASGLLELNQFETEEEKSIFIERVYEEANGKELKIACSQSCSRLMEKLISASTVSQIKRLFSKFIGHFLNLVQHRFASHCCECLFIHAAQHVTSEMKKKSSKEKENLEEDSTSELQLEDLFLKAISELEGNWGYLLTERFASHTIRLLLLVLAGKPLRNSSTTTVIASRKKEYLASKVGTQLDPSISEKRAVPTSFNKALEKMMKDLVAGLDNTYLRALATHPVGNPVLQLLLSVELSHMGKSKAKDPDSLLRRLVPDENLQGDGESANFLKGLFYDPVGSRLLETIVQDAPGKFFRLFYKILVRERIGSFSRNEIAGHVVVRILERLSKDDLKSAMDMILPEVAPLVERSRLTVIKALIERGIVRGVDLGPLAAALLSAYGDDAVSRINNMLKLQRSNQESDGTTSSSNTSSPEQLHGSLLAQAMLKSTGPLSELVQSSLLAVTTETLISIAQDPVVSHVLQDALTLPTSTPQFRRQITSRFSGKIAELALHSSGSHVVDALWPATKDLLFVKQRFAEELVVHERALRDSFVGRAVWRNWSMDLYKRKRGSWIAIAKGLEDSTDINPNALTHKPKSNIDLARARFAAKANGSKAPS
What is the function of this protein?
RNA-binding nucleolar protein required for pre-rRNA processing.  Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity).
What are the official names of this protein?
Nucleolar protein 9, Pumilio domain-containing protein NOP9.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: EFTU_MALP2
Sequence: MAKQKFDRSKAHVNIGTIGHIDHGKTTLTAAICTYLAKKGGAKAMKYDEIDKAPEEKARGITINTAHVEYETENRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAASDGPMPQTREHILLARQVGVPKMVVFLNKCDMVSDAEMQDLVEMEVRELLSSYGFDGDNTPVIRGSALKALEGDATWEAKIDELMASVDSYIPTPTRDTDKPFLLAVEDVMTITGRGTVVTGRVERGTLKLNDEVEIVGIHDTRKAVVTGMEMLRKTLDEVKAGDNAGILLRGIDRKDVERGQVLAKPGSIKPHKQFEAEIYALKKEEGGRHTPVLNGYRPQFYFRTTDVTGQITLDKGVEMINPGDNTKITVELISPIAVEEGSKFSIREGGRTVGAGTVTKVIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AFSA_STRGG
Sequence: MPEAAVLIDPVPTMDAEAEVVHPVGIEMVHRTRPEDAFPRNWVRLGRDRFAVEAVLPHDHPFFAPVGDDLHDPLLVAEAMRQAAMLAFHAGYGIPLGYHFLLTELDYVCHPEHLGVGGEPTEIGLEVFCSDLKWRAGLPAQGRVGWAVHRGDRLAATGVAATRFSTPKAYRRMRGDVPVEGISLPETAPVPASPAGRARVEDVVLSGTGREGVWELRVDTRHPTLFQRPNDHVPGMLLLEAARQAACLVAGPAGIVPVEARTRFHRYSEFGSPCWIGAVVQPGADEDTVTVRVTGHQDGETVFSTVLSGPRAHG
What is the function of this protein?
Involved in the biosynthesis of A factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone), a gamma-butyrolactone autoregulator that triggers secondary metabolism and morphogenesis in Streptomyces (PubMed:17277085).  Catalyzes beta-ketoacyl transfer from 8-methyl-3-oxononanoyl-acyl carrier protein (ACP) to the hydroxyl group of dihydroxyacetone phosphate (DHAP), thus producing an 8-methyl-3-oxononanoyl-DHAP ester (PubMed:17277085).
What are the official names of this protein?
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase, A-factor biosynthesis enzyme.
What is the protein family that this protein belongs to?
Belongs to the AfsA family.
Protein: FLIP_PECCC
Sequence: MSALPNYFRITALLRTQRYGLAIGLLFMAPSVWAQLPGIVTQPLPNGGQSWTLSVQTLVLLTSLTFLPAALLMMTSFTRIIIVLSLLRNALGTPTAPPNQVLLGLTLFLTFFVMSPVLNRVYDEAYLPFSQDQISMEVAIERGAEPVREFMLRQTRETDLALFTRLAEIPEIQGPEAVPMRVLLPAFVTSELKTAFQIGFTVFIPFLIIDLVVASVLMALGMMMVPPATISLPFKLMLFVLVDGWQLLLGSLAQSFYS
What is the function of this protein?
Plays a role in the flagellum-specific transport system.
What are the official names of this protein?
Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein MopC.
What is the protein family that this protein belongs to?
Belongs to the FliP/MopC/SpaP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Protein: YBBJ_ECOLI
Sequence: MMELMVVHPHIFWLSLGGLLLAAEMLGGNGYLLWSGVAAVITGLVVWLVPLGWEWQGVMFAILTLLAAWLWWKWLSRRVREQKHSDSHLNQRGQQLIGRRFVLESPLVNGRGHMRVGDSSWPVSASEDLGAGTHVEVIAIEGITLHIRAVSS
What are the official names of this protein?
Inner membrane protein YbbJ.
What is the protein family that this protein belongs to?
To M.jannaschii MJ0826.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TX1B_CHEPU
Sequence: MKFSLFFSVFFLAVLHACLSESEIDLEDEEHFMSSDSFLSEIQDESRGKTCIERNKECTNDRHGCCRGKIFKDKCTCVKNGKTEKCVCTQKKWAKIIESYIGDIPALPKPVDDKCVPKHADCSKRKDECCKGGIFKYQCKCYDMYDDDGEKTDLCGCVSPVEHQAIEGALRIAKKLIGDRWGR
What is the function of this protein?
Spider venom toxin that exhibits cytolytic activity by forming an alpha-helix across the membrane (PubMed:20657014).  Lethal to insect larvae (PubMed:20657014, PubMed:24717175).  Causes instant paralysis and death in the larvae of the flesh fly (S. carnaria) at doses of 20 ug/g, at doses of less than 10 ug/g causes reversible paralysis (PubMed:20657014).  Has cytolytic activity against insect Sf9 cells (PubMed:20657014).  Causes stable and irreversible depolarization of fly muscle fibers, leading to contracture at higher toxin concentrations (PubMed:20657014).  Destabilizes membranes (PubMed:20657014).
What are the official names of this protein?
DELTA-miturgitoxin-Cp1b, DELTA-MGTX-Cp1b, Toxin CpTx1, Toxin CpTx1b.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. Double-CSTX subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Probably forms a transmembrane alpha-helix in the target cell membrane.
Protein: SYGB_LISIN
Sequence: MSKDFLLEIGLEEMPAKYVTSSVLQLEKRVTDWLKDNQIEFKEIKTYSTPRRLTVLVEEMAEEQANRVEEAKGPAKKIALDDEGNWSKAALGFAKSQKVAPEDLTFREIKGVEYIYIKKEVIGEKTTALLPSLEKVVTSMTFPVSMHWGSNDLRYIRPIKWLIAMFGEEIIPFEITGVSTSNTSRGHRFLGKTATINQPSDYPHALLEQFVVVNASERKQAIVEQLRELETMENWQIREDDDLLEEVTNLVEYPTVLAGNFEKEYLELPEEVLITTMKEHQRYFPVFSQEGELLPHFVTVRNGNHENLDTVARGNEKVLRARLSDADFFYQEDLKITIDEAVAKLQNIVFHEKLGTLTEKMERVQKVALMLADYLNWQEEDKQDIIRLTNIYKFDLVTNIVGEFPELQGLMGEKYALLQGEKPAIATAIREHYLPSSAEGVLPQTDLGSLIAIADKLETLIGFFCVNIVPTGSADPFGLRRSAFGAMRIIQANGWDIPMLEVISRIVDMERAEGATELPSADVKKEVQTFLKNRLRVILQGHHIRHDIIDAVIGGDPNVIPQLIDRAQILNKHADAEWFRPTIEALTRVVKISKKYEDGVEVDPNLFENEYEQELFDKLEKLKYDYAGLTIVDRLKAFADLRTTIDGYFDNTLVMTDNDELKNNRLALLFELASFIKEFAQMDEINVK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2714_BACC0
Sequence: MNDLRYPIGQFTYKRPITEEMIDTWIQEIEDLPNELTKAIKDLDQKQLDTPYRVGGWTVRQVVHHVVDSHMNSYIRFKLALTEKNPTIKPYKEEKWAELPDSKLPVDVSLVMLESLHKRWVNLLYSLELEDLEKTFNHPDTGETKLAAAIGLYAWHGRHHTAHITSLRKRLNW
What is the function of this protein?
Possible metal-dependent hydrolase.
What are the official names of this protein?
Putative metal-dependent hydrolase BCAH820_2714.
What is the protein family that this protein belongs to?
Belongs to the metal hydrolase YfiT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACYP_CHLTE
Sequence: MTEKRVHIIVSGLVQGVGFRMFVLREASARSLSGWTRNLPDGTVEVEAQGDSGRVDELIRQIRIGPSRSSVTSIKVKEIEVDTSCREFRILT
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: STEEP_SCHPO
Sequence: MSNQGKDSFKAYSYFCPCGQLFLTIHVSLTRLPQRQLDKRHVVDEKLNHIAHFSTGNKYYITRSDGGYEQRIQLLCRRCTLECAYALEAAPGYIYVDPTLVNEKPVTVSVSNLKE
What is the function of this protein?
May stimulate membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment.
What are the official names of this protein?
ER exit protein.
What is the protein family that this protein belongs to?
Belongs to the STEEP1 family.
Protein: Y299_MYCTU
Sequence: MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPLGNAGVAALREAASVVTALLC
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Upon expression in M. smegmatis inhibits colony formation.  Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312.
What are the official names of this protein?
Toxin Rv0299.
Protein: CLPP1_CHLT2
Sequence: MPEGEMMHKLQDVIDRKLLDSRRIFFSEPVTEKSAAEAIKKLWYLELTNPGQPIVFVINSPGGSVDAGFAVWDQIKMISSPLTTVVTGLAASMGSVLSLCAVPGRRFATPHARIMIHQPSIGGTITGQATDLDIHAREILKTKARIIDVYVEATGQSPEVIEKAIDRDMWMSANEAMEFGLLDGILFSFNDL
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_UREU1
Sequence: MKWKEFIINQTKQDYLRNIIQKVNTIENHQVVYPLKKQRFRCFNFFDIEQTKVVILGQDPYHTPKMANGLCFSVDLGNNLPGSLVNIFKALEYDLQIKRTNPDLSDWAKQGVLLLNTVLTVNAHQANSHKDFGYDQLIKNAFIELKKQKHVVYLLWGKQAMSYIDLIDKDHNLILCAPHPSPLSAHRGFLTCKHFSACNDYLIKHFRTPIKW
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBT8_ARATH
Sequence: MERIMINPLLSIQNSPTKFLKPPLSSIHRQQQQQERQSNNNTLFMGEARPRRATTFACLSIRRRRNNNGVSEFEETARFEQVGGKGISVLCGLGYWVQGSRCFPWLALNFHMVHSLALQPSTLQLVQYSCSLPMVAKPLYGVLSDVLYIGSGRRVPYIAIGVFLQVLAWGSMGIFQGAREVLPSLVACVLLSNLGASITEVAKDALVAEYGLRYRINGLQSYALMASAAGGVLGNLLGGYLLLTTPPKISFLVFSALLSLQLVVSLSSKEESFGLPRIAETSSVLESVKKQISNLKEAIQADEISQPLIWAVVSIAMVPLLSGSVFCYQTQVLNLDPSVIGMSKVIGQLMLLCLTVVYDRYLKTLPMRPLIHIIQLLYGLSILLDYILVKQINLGFGISNEVYVLCFSSLAEILAQFKILPFAVRLASMCPQGCEGSVTSFLASTLCLSQIVSAFLGVGLANLIGITSSNYSNLSSGILIQSLAALAPLCFMHLVPMSEPVIEKEGKRGISKRSRRNRRVGRVVDKESVTYRRERESEEAQR
What is the function of this protein?
Could mediate folate transport.
What are the official names of this protein?
Probable folate-biopterin transporter 8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: MIAA_AKKM8
Sequence: MTLFLAGPTGSGKSAVAVELAEMLDAEIVSSDAYQVYRELPILTAAPSPADRERVPHHMVSIIPVQKNWNATEHYHRAMRCMEEIHARGKIAIVTGGSGLYFKFLSHGLSEAPPGDAALRAAFANCSTEALYARLSSLDPEGAASTDASNRRYVERNLEIVLAGGKPLSFWKRNWLTPPRGPGWVISRDVPELDERIAHRAARMMQEGAVEETASLGPCSATAERTLGLALIRSMLRGEISRENCQGQLALATRQYAKRQRTWLKREQWLRKLPASPSDSPRALAERIMEELGH
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: NUOH_PSE14
Sequence: MTWFTPDVIDAIIAVVKAIVVLLAVVVCGALLSFIERRLLGWWQDRYGPNRVGPFGMFQIAADMLKMFFKEDWTPPFADKVIFTLAPVVAMSALLIAFAVIPITPTWGVADLNIGLLFFFAMAGLSVYAVLFAGWSSNNKFALLGSLRASAQTVSYEVFMGLALMGIVVQVGSFNMRDIVEYQAQNLWFIIPQFFGFCTFFIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFVGEYIGIILISALLVTLFFGGWHGPFDILPSLAFFWFALKTAFFIMLFILLRASIPRPRYDQVMDFSWKFCLPLTLINLLVTAAIVLLNTPAGSVQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECR_RHIE6
Sequence: MAKRVTGPEIEKLIQLLAKVPGLGPRSARRAALHLIKKKDQLLGPLSNAMGEAYDKVKICSRCGNVDTVDPCTVCTDAQRDQSVIIVVEDVSDLWALERAGAMNAAYHVLGGTLSPLDGIGPDDLNIRGLIDRIGEGGIRELIIAVNATVEGQTTAHYITDQLQGLDVKITRLAHGVPVGGELDYLDEGTLAAALRARTVI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: ECM14_AJEDR
Sequence: MRQFTHGTLLAILALANTISAIPSFSANNYPAHPAEPLALFAQSQPQAPLGLWTRLRNSVIERLWGVPPQQRNHRGGNKQYPFYSAPASLQARYSDDVVLRFRLQTADEVKALVEASNILFLDVWASTDEWVDIRLAKDVVPSLLGLLPKSLQTAHVPLIHDLPQTVYESYPSSSQRPTDNGRGFLPSRESSSDVTNIFFEDYQPLSVIGPWMRLLASMFPSHVQLISIGSSFEGRDIPALRVGVRPANDPKPRKTVIIGGGSHAREWIGVSTVNYVAYSLITTYGKSTPISTLLEQFDFIFIPTINPDGYVHTWETDRLWRKNRQETSLPFCPGVDLDRTWGFEWNGNATGDNPCSESYGGDEPFAGTEARQLAGWVKEQTEQHNVKFVAYLDLHSYSQQVLYPYSYSCLPRPPNLENLEELAMGIAKAIRLTNRQSYTVSSACQGFTASQKKVKLDTFPRMESTGGSALDWFYNDVGVKYSYQLKLRDKGSYGFLLPRENIVPTGKEVFNAVMVLAKFLLGSDGFEGLNWEAEFQRLNEADKPILDDGDDDEEEDGQDKKDDSWIPDEYKNDNDHDDDDDGWGLRRRRKR
What is the function of this protein?
Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.
What are the official names of this protein?
Inactive metallocarboxypeptidase ECM14.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Vacuole. Secreted.
Protein: DCA13_HUMAN
Sequence: MKVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK
What is the function of this protein?
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that plays a key role in embryo preimplantation and is required for normal meiotic cycle progression in oocytes (PubMed:16949367, PubMed:30111536, PubMed:31492966).  Acts as a maternal factor that regulates oocyte and zygotic chromatin tightness during maternal to zygotic transition (By similarity).  Also involved in the transformation of the endometrium into the decidua, known as decidualization, providing a solid foundation for implantation of blastocysts (PubMed:35932979).  Recognizes the histone methyltransferases SUV39H1 and SUV39H2 and directs them to polyubiquitination and proteasomal degradation, which facilitates the H3K9me3 removal and early zygotic gene expression, essential steps for progressive genome reprogramming and the establishment of pluripotency during preimplantation embryonic development (PubMed:30111536).  Supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting the polyubiquitination and degradation of PTEN, a lipid phosphatase that inhibits PI3K pathway as well as oocyte growth and maturation (PubMed:31492966).  Targets PMP22 for polyubiquitination and proteasomal degradation (By similarity).
What are the official names of this protein?
DDB1- and CUL4-associated factor 13, WD repeat and SOF domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat DCAF13/WDSOF1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component.