PharMolix/UniProtQA huggingface dataset:
Protein: SPSA4_ORYSJ
Sequence: MAGNDWINSYLEAILDAGGAAGEISAAAGGGGDGAAATGEKRDKSSLMLRERGRFSPARYFVEEVISGFDETDLYKTWVRTAAMRSPQERNTRLENMSWRIWNLARKKKQIEGEEASRLAKQRLEREKARRYAAADMSEDLSEGEKGENINESSSTHDESTRGRMPRIGSTDAIEAWASQHKDKKLYIVLISIHGLIRGENMELGRDSDTGGQVKYVVELARALGSTPGVYRVDLLTRQISAPDVDWSYGEPTEMLSPRNSENFGHDMGESSGAYIVRIPFGPRDKYIPKEHLWPHIQEFVDGALVHIMQMSKVLGEQVGSGQLVWPVVIHGHYADAGDSAALLSGALNVPMIFTGHSLGRDKLEQLLKQGRQTRDEINTIYKIMRRIEAEELCLDASEIIITSTRQEIEQQWGLYDGFDLTMARKLRARIKRGVSCYGRYMPRMIAVPPGMEFSHIVPHDVDQDGEEANEDGSGSTDPPIWADIMRFFSNPRKPMILALARPDPKKNITTLVKAFGEHRELRNLANLTLIMGNRDVIDEMSSTNSAVLTSILKLIDKYDLYGQVAYPKHHKQSEVPDIYRLAARTKGVFINCAFIEPFGLTLIEAAAYGLPMVATRNGGPVDIHRVLDNGILVDPHNQNEIAEALYKLVSDKQLWAQCRQNGLKNIHQFSWPEHCKNYLSRVGTLKPRHPRWQKSDDATEVSEADSPGDSLRDVHDISLNLKLSLDSEKSSTKENSVRRNLEDAVQKLSRGVSANRKTESVENMEATTGNKWPSLRRRKHIVVIAIDSVQDANLVEIIKNIFVASSNERLSGSVGFVLSTSRAISEVHSLLTSGGIEATDFDAFICNSGSDLCYPSSNSEDMLSPAELPFMIDLDYHTQIEYRWGGEGLRKTLICWAAEKSEGGQVVLVEDEECSSTYCISFRVKNAEAVPPVKELRKTMRIQALRCHVLYSHDGSKLNVIPVLASRSQALRYLYIRWGVELSNMTVVVGESGDTDYEGLLGGVHKTIILKGSFNAVPNQVHAARSYSLQDVISFDKPGITSIEGYGPDNLKSALQQFGILKDNV
What is the function of this protein?
Plays a role in photosynthetic sucrose synthesis by catalyzing the rate-limiting step of sucrose biosynthesis from UDP-glucose and fructose- 6-phosphate.  Involved in the regulation of carbon partitioning in the leaves of plants.  May regulate the synthesis of sucrose and therefore play a major role as a limiting factor in the export of photoassimilates out of the leaf.  Plays a role for sucrose availability that is essential for plant growth and fiber elongation (By similarity).
What are the official names of this protein?
Probable sucrose-phosphate synthase 4, Sucrose phosphate synthase 4F, OsSPS4F, UDP-glucose-fructose-phosphate glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family.
Protein: LEPA_XYLFT
Sequence: MSSDPMRNIRNFSIIAHVDHGKSTLADRIIQLCGGLEAREMEAQVLDSNPIERERGITIKAQSVSLLYKAQDGQNYHLNLIDTPGHVDFSYEVSRSLAACEGALLVVDASQGVEAQSVANCYTAVEQGLEVVPILNKIDLPTADTERAKAEIETVIGIDASEAVAVSAKTGLYVEQVLEAIVQRIPAPQPRDTEKLQALIIDSWFDNYLGVVSLVRVMQGEITPGNKLLVMSTGRSHQVDAVGVFTPKRKTLAKLTAGEVGWVTASIKDVHGAPVGDTLTLTSDPAPKPLPGFQEVQPRVFAGLFPVDAEDYPDLREALEKLRLNDAALRFEPENSEAMGFGFRCGFLGMLHMEIVQERLEREYDLNLITTAPTVIYEVLKNDGTLVAMDNPAKMPPINQINEIREPIIRSNILTPPDYVGAVITLCEEKRGSQISITYLGNQVQVAYELPMAEVVLDFFDKLKSVTRGYASLDYHFLRFQEGPFVRVDTLINGDRVDALSVIVHRHQAERRGRELCEKMKDLIPRQMFDVAIQAAIGSQIISRSTVKAMRKNVLAKCYGGDISRKKKLLEKQKEGKKRMKQIGRVEIPQEAFLAVLQIDNK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MUTS_XANAC
Sequence: MGRRNRRATRHGESSKSALIDCHIPEEHFLQSTDPKEKTKNAGGAVEHTPLMKQFFAAKSDYPDLLLFFRMGDFYELFYDDARKAARLLDITLTQRGSSGGAPIPMAGVPVHAYEGYLARLVALGESVAICEQIGDPALAKGLVERKVVRIVTPGTVTDEALLDERRDTLLMAISRSKQGYGLAWADLAGGRFLVNEVDSADALEAEIARLEPAELLVPDEDNWPEFLRGRIGVRRRPPWLFDADSGRRQLLAFFKLHDLSGFGIDDKPCATAAAGALLGYVEETQKQRLPHLTSIAMEVASEAISMNAATRRHLELDTRVDGDTRNTLLGVLDSTVTPMGGRLLRRWLHRPLRLRDVLVQRHHAVGTLIDAAADADLREAFRALGDLERILTRVALRSARPRDFSTLRDGLALLPKVRAILAPLDSPRLQALHAELGEHDATAHLLISAVAETPPLKLSDGGVIATGYDADLDELRRLSTNADQFLIDLEQRERASSGIATLKVGYNRVHGYYIEISKGQAEKAPLHYSRRQTLTNAERYITEELKSFEDKVLSARERSLSREKLLYEGLLDALGTELEGLKRCAGALSELDVLAGFAERAQALDWSQPELDSAPCLRIERGRHPVVEAVREQPFEPNDLDLHSDRRMLVITGPNMGGKSTYMRQNALIVLLAHIGSYVPASRAVIGPIDRILTRIGAGDDLARGQSTFMVEMAETSYILHHATPQSLVLMDEIGRGTSTYDGLALADAVARHLAQTNRCYTLFATHYFELTALADASHAGGASGIANVHLDAVEHGERLVFMHAVKDGPANRSFGLQVAALAGLPKAAVTQARRRLAELEQRGGESHSAQMAPTALDAPQQFGLFTAPSSAAQEALQALDPDELTPKQALEALYRLKALL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: CAIA_ESCF3
Sequence: MDFNLNDEQELFVAGIRELMASENWEAYFAECDRDSVYPERFVKALADMGIDSLLIPEEHGGLDAGFVTLAAVWMELGRLGAPTYVLYQLPGGFNTFLREGTQEQIDKIMAFRGTGKQMWNSAITEPGAGSDVGSLKTTYTRRNGKIYLNGSKCFITSSAYTPYIVVMARDGASPDKPVYTEWFVDMSKPGIKVTKLEKLGLRMDSCCEITFDDVELDEKDMFGREGNGFNRVKEEFDHERFLVALTNYGTAMCAFEDAARYANQRVQFGEAIGRFQLIQEKFAHMAIKLNSMKNMLYEAAWKADNGTITSGDAAMCKYFCANAAFEVVDSAMQVLGGVGIAGNHRISRFWRDLRVDRVSGGSDEMQILTLGRAVLKQYR
What is the function of this protein?
Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
What are the official names of this protein?
Crotonobetainyl-CoA reductase, Crotonobetainyl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_YERPN
Sequence: MTQLTHINTAGEAHMVDVSAKNETVREARAEAFVDMQAATLAMIIDGSHHKGDVFATARIAGIQAAKKTWELIPLCHPLLLTKVEVKLEAQPEHNRVRIETCCRLTGKTGVEMEALTAASVAALTIYDMCKAVQKDMIIGPVRLLTKSGGKSGDFKVDI
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: RSXC_SHIDS
Sequence: MLKLFSAFRKNKIWDFNGGIHPPEMKTQSNGTPLRQVPLAQRFVIPLKQHIGAEGELCVSVGDKVLRGQPLTRGRGKMLPVHAPTSGTVTAIAPHSTAHPSALAELSVIIDADGEDCWIPRDGWADYRSRRREELIERIHQFGVAGLGGAGFPTGVKLQGGGDKIETLIINAAECEPYITADDRLMQDCAAQVVEGIRILAHILQPREILIGIEDNKPQAISMLRAVLADSHDISLRVIPTKYPSGGAKQLTYILTGKQVPHGGRSSDIGVLMQNVGTAYAVKRAVIDGEPITERVVTLTGEAIARPGNVWARLGTPVRHLLNDAGFCPSADQMVIMGGPLMGLTLPWLDVPVVKITNCLLAPSANELGEPQEEQSCIRCSACADACPADLLPQQLYWFSKGQQHDKATTHNIADCIECGACAWVCPSNIPLVQYFRQEKAEIAAIRQEEKRAAEAKARFEARQARLEREKAARLERHKSAAVQPAAKDKDAIAAALARVKEKQAQATQPIVIKAGERPDNSAIIAAREARKAQARAKQAELQQTNDAATVTDPRKTAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVEAAIARAKARKLEQQQANAEPEEQVDPRKATVEAAIARAKARKLEQQQANAEPEEPVDPRKAAVEAAIARAKARKLEQQQANAEPEEPVDPRKAAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVAAAIARVQAKKAAQQKVVNED
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rsx electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MCSB_STAHJ
Sequence: MSDMNAHISEWMKETEESPIVMSSRIRLARNLENHVHPLMFPSEQDGFRVINEVQDVLPDLDLMRLDTMDQQNKMKLVAKHLISPELIKQPASAVLLNKDESISIMINEEDHIRIQAMGTDLSLQDLYNIASEIDDTLDQSLDISYDEHLGYLTTCPTNIGTGMRASVMLHLPGLSIMKRMNRIAQTINRFGFTIRGIYGEGSQVYGHIYQISNQLTLGKTEDEIIDNLTEVVQQIINEEMQIRERLTQYNELETLDRIYRSLGILQNSRIISMEEASYRLSEVKLGIDLGYLTLSDFKFNELMVSIQSAFIYNDEDETISVNEKRANILREYTQ
What is the function of this protein?
Catalyzes the specific phosphorylation of arginine residues in proteins.
What are the official names of this protein?
Protein-arginine kinase.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: RL30_THISH
Sequence: MANAKDLKVTLVRSLNGRLKAHIACVRGLGVRRIHSPVVVKDTPENRGMINKVSYMLKVEEA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: AKT1_ALTAL
Sequence: MVFAAPCWVPPLPSDLPDSTTLEEFIFCQVKDSQTRSELDRSILICGTQGKEYTVQESMERTGRLAQGLSAWLDWPQKPSEEDWKVAAIFNINCVEFFSISHAIHRLGGTVSAINASSTADELEAQLRLSNAQAIFTCNTLLKIAMKASQKVGIPLANIFLTDAPGSYRPDDVYPFQEIDNIVRTARSSLPLLQLGRGQGSSTPAYICFSSGTSGAQKPVLLSHQGIIANIVQINTFEKFRQKGPNVSLCILPLAHSYGLVCVAYNALYRGDRLAVLPSSDVEDLLSIVEKLRINTLYLVPTLLSRILSGGKAGGHDLSCVKEVYTGGAPLHPMLGEHILRHHPTWKTKQCYGATEAGTAVSVTSDCDLWPGSVGCLLPGVQAKIIRSDGSETTKHDESGELWVSSPSLAIGYLSNPLATEATFTVDNTGRTWLRTGDEAKICLSPNGNEHLFIVDRIKDIIKVKGFQVAPVELEQLLLSNDFVEEVAITSRQDKRGEERPQAFVVRTHEGLKEPQDAVSESLQALVKARKARYKWLHPHVIFVDSLPKTTSGKIMRRALRNMCPANSEVNGRLSSKI
What is the function of this protein?
Acyl-CoA ligase; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) AK-toxins responsible for Japanese pear black spot disease by the Japanese pear pathotype (PubMed:10432635, PubMed:20348386).  AK-toxins are esters of 9,10-epoxy 8-hydroxy 9-methyldecatrienoic acid (EDA) (PubMed:22846083).  On cellular level, AK-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).  The acyl-CoA ligase AKT1, the hydrolase AKT2 and enoyl-CoA hydratase AKT3 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) structural moiety (PubMed:10432635, PubMed:10975654, PubMed:22846083).  Part of the EDA biosynthesis occurs in the peroxisome since these 3 enzymes are localized in peroxisomes (PubMed:20348386).  The exact roles of the 3 enzymes, as well as of additional AK-toxin clusters enzymes, including AKT4, AKT6 and AKTS1, have still to be elucidated (PubMed:10432635, PubMed:10975654, PubMed:22846083).  The Cytochrome P450 monooxygenase AKT7 on the other side functions to limit production of EDA and AK-toxin, probably via the catalysis of a side reaction of EDA or its precursor (PubMed:24611558).
What are the official names of this protein?
Acyl-CoA ligase AKT1, AK-toxin biosynthesis protein 1.
What are the subcellular locations of this protein?
Peroxisome. Note=The peroxisomal location requires the C-terminal tripeptide peroxisomal targeting signal.
Protein: GUAC_STRPZ
Sequence: MFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIIDETIAEQLAKEGYFYIMHRFDEDSRKPFIKRMHEQGLIASISVGVKACEYDFVTSLKEDAPEFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHIESPGKTVEVDGETFKEYYGSASEYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISYAGGKDLDSLRHVDYVIVKNSIWNGDSI
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: TRPB_BACFN
Sequence: MKSFLVDQDGYYGEFGGAYVPEILHKCVEELQNTYLDVIESEDFKKEFDQLLRDYVGRPSPLYPARRLSEKYGCKMYLKREDLNHTGAHKINNTIGQILLARRMGKKRIIAETGAGQHGVATATVCALMNMECIVYMGKTDVERQHINVEKMKMLGATVVPVTSGNMTLKDATNEAIRDWCCHPSDTYYIIGSTVGPHPYPDMVARLQSVISEEIKKQLQEKEGRDYPDYLIACVGGGSNAAGTIYHYIDDERVRIVLAEAGGKGIETGMTAATIQLGKMGIIHGARTFVIQNEDGQIEEPYSISAGLDYPGIGPMHANLADKKRAMVLAVNDDEAIRAAYELTRLEGIIPALESAHALGALEKITFKPEDVVVLTVSGRGDKDIETYLG
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: PTH_MYCBO
Sequence: MAEPLLVVGLGNPGANYARTRHNLGFVVADLLAARLGAKFKAHKRSGAEVATGRSAGRSLVLAKPRCYMNESGRQIGPLAKFYSVAPANIIVIHDDLDLEFGRIRLKIGGGEGGHNGLRSVVAALGTKDFQRVRIGIGRPPGRKDPAAFVLENFTPAERAEVPTICEQAADATELLIEQGMEPAQNRVHAW
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CXA5_MOUSE
Sequence: MGDWSFLGEFLEEVHKHSTVIGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKQKLRDAEKAKEAHRTGAYEYPVAEKAELSCWKEVDGKIVLQGTLLNTYVCTILIRTTMEVAFIVGQYLLYGIFLDTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMMAVAGLSLFLSLAELYHLGWKKIRQRFGKSRQGVDKHQLPGPPTSLVQSLTPPPDFNQCLKNSSGEKFFSDFSNNMGSRKNPDALATGEVPNQEQIPGEGFIHMHYSQKPEYASGASAGHRLPQGYHSDKRRLSKASSKARSDDLSV
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
What are the official names of this protein?
Gap junction alpha-5 protein, Connexin-40, Cx40.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: HAPR2_HUMAN
Sequence: MEEQQKEGEAEVAEHWFSKWERQCLAEAEQEEQLPPELQEEAAAELAGLKSEKQKLWHLFQISATAVAQLYKDSGCQQQGLSMWDPFQNAAMAVTSLYKESGDAHQRSFDLGVQVGHQRRIKDVLEWVKKGRSTIRREDLISFLCGKVPPAPPPPRTPRTPPKPPTGVTSQAVATESSSSVDVDLQPFQEAIALHGLSGAMAGISMRSGDSPQDSGVASSGRRKTSFLEDDLNPFDSEELALHLDSGGIRKRTSAQCSDGITDSPIQKRNRMV
What is the function of this protein?
Together with HAPSTR1 plays a central regulatory role in the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, and protein misfolding (PubMed:36631436).  Regulates these multiple stress response signaling pathways by stabilizing HAPSTR1, but also independently of HAPSTR1 (PubMed:36631436).
What are the official names of this protein?
HUWE1-associated protein modifying stress responses 2.
What is the protein family that this protein belongs to?
Belongs to the HAPSTR1 family.
Protein: QUEF_SODGM
Sequence: MTNYDQHHALQSLTLGKPTPYRERYDPSLLQAVPRALNRDLLGLQATALPFHGADIWTLYELSWLNDAGIPQVAIGEIALNATSTNLIESKSFKLYLNSLNQTSFPSREAVRVRLAEDLSRCADGEVQVVLRALSDFTSSPLLDFDGECIDDQPIHIDDYTFTNRYLEGAAGGSVVSETLVSHLLKSNCLITHQPDWGSVQIRYRGARIDREALLRYLVSFRQHNEFHEQCVERIFCDVMQFCRPETLTVYARYTRRGGLDINPWRSNTHFSPATGRLARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_LEGPL
Sequence: MTNQKQTTHFGFKSVDWNEKEKKVAEVFHSVAKNYDRMNDLMSLGIHHLWKRYTIELSHVRPGQSVLDLAGGSGDLTRLLSQKVGDSGQVILADINAAMLHVGRDRLLDEGLFKNIRYVQGNAQCLPFADNSFHCITMGFGLRNVTDKDEALQSMYRVCKPGGKLMVLEFSTPVFPGLKPVYDWYSFNILPKIGKFVANDEASYQYLAESIRMHPDQETLKAMIERVGFEDCHYHNLSGGIVALHIAYKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: SECY_BUCAP
Sequence: MIKKLGLNFKNTKKVTNELKQRIASVVIALIIFRIGSFIPIPGIDTTILSRILNDQKGTIIEMFNMFSGGALSRASIFALGIMPYISSSIIIQLLTLVIPSLSEIKKEGEVGRTKINQYTRYTTLVLALFQSIGIVTSLPKISGMNQIIIHPDFYFYFTAIIILVTGTMFLMWLGELITECGIGNGISIIIFIGIIAGLPSAIVHTIEQTRQGDLHILLFLCVLILIFSVVFLVVFIERSQRKIIIHYAQRQKGRRIYSTQSTHLPLKINMAGVIPAIFASSVVLFPVTIISWFGIDRKCYLLKTIFFYFQPNQPLYLILYVFSIIFFCFFYTGLVFNPRETADNLKKSGGFISGIRPGEQTAKYINKIMIRLTLFGSLYIAFICLIPEFMRSAMNVPFYFGGTSLLIVVVVIMDFIAQIQTLIMSSQYESVLKKANLN
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PRMB_VIBCH
Sequence: MEAILDKIFVEEAVSELHTLQDMIRWTVSRFNAANLFYGQGTDNAWDEAVQLILPTLYLPIDVPPHVLSSRLTSSERLRVVERVIKRINDRTPVAYLTNKAWFCGLEFFVDSRVLVPRSPIGELIQNRFEPWLTEEPTRIMDLCTGSGCIAIACANAFPEAEVDAIDISVDALNVAEQNIQDHGLEQQVFPIRSDLFRDLPQEQYDLIVTNPPYVDQEDMDSLPSEFRHEPELGLAAGSDGLKLARRILANAPLYLKENGILVCEVGNSMVHMMEQYPHIPFTWLEFENGGHGVFLLTREQLIDCAADFALYKD
What is the function of this protein?
Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue.
What are the official names of this protein?
50S ribosomal protein L3 glutamine methyltransferase, L3 MTase, N5-glutamine methyltransferase PrmB.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
Protein: YBM3_YEAST
Sequence: MIYPLFRICILGAFLLGSYACLENSTQKGIEGVTLSHNSVQINNTLAKSAPFCESDALSMNYSTENMLSNNACDYTKNSSYPYIITIITKAFDNALENSLNLQANRKLYHRVGTCIQNIFYQLLLTVNY
What are the official names of this protein?
Putative uncharacterized protein YBR013C.
Protein: H1T_MACMU
Sequence: MSETVPAASAGAVPAVMEKPLTKKRGKKPAGLTSASRKAPNLSVSKLITEALSVSQERVGMSLAALKKALAAAGYDVEKNNSRIKLSLKSLVNKGILVQTRGTGASGSFKLSKKVLPKSTRRKANKSASAKTKKLVLSRDSKSPKTAKTNKRAKKPRATAPKKAVRSGRKAKGAKGKQQQKSPVKARATKPKLTQHHKANIRKATSRK
What is the function of this protein?
Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes.  Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination.  Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration.
What are the official names of this protein?
Histone H1t, Testicular H1 histone.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
Protein: LEU1_BACLD
Sequence: MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAQQLEKLGVNIMEAGFPASSPGDFNAVKEIARTIKNCSVTGLARSVKGDIDSAWEALKDGAEPRLHIFIATSDIHLKYKLKKTREQVLEQAVAMVKYAKERFPIVQWSAEDACRTDLPFLAEIVSEVIAAGADVVNLPDTVGYLAPAEYGNIFRYIKENARNADKVQLSAHCHDDLGMAVANSLAAIENGADQVESVINGIGERAGNASLEEIAVALHIRKDFYQAESTIQLNEIKRTSDLVSKLTGMAVPRNKAVVGDNAFAHESGIHQDGFLKEKTTYEIISPELVGVKTDALVLGKHSGRHAFKDKLQNLGFQLGEEEINKFFNIFKELTGKKKEFTDEDLISLILEEKTADRKIGYDFISLQVHYGTSQVPTATVSLKDQETDQVIQEAATGAGSVEAVYNTLKRCMDKEVQLLDYRIQSNRKGQDAFAQVYVRVMIDGKESGGRGVAQDVLEASAKAYLNAVNRYLVLKTNTEGLSKQAAVGS
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: DIAP2_HUMAN
Sequence: MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITTAAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPDNRRVPLERSRSRHNGAISSK
What is the function of this protein?
Could be involved in oogenesis.  Involved in the regulation of endosome dynamics.  Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
What are the official names of this protein?
Protein diaphanous homolog 2, Diaphanous-related formin-2, DRF2.
What is the protein family that this protein belongs to?
Belongs to the formin homology family. Diaphanous subfamily.
What are the subcellular locations of this protein?
[Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.
Protein: VIRF_SHIDY
Sequence: MMDMGHKNKIDIKVRLHNYIILYAKRCSMTVSSGNETLTIDEGQIAFIERNIQINVSIKKSDSINPFEIISLDRNLLLSIIRIMEPIYSFQHSYSEEKRGLNKKIFLLSEEEVSIDLFKSIKEMPFGKRKIYSLACLLSAVSDEEALYTSISIASSLSFSDQIRKIVEKNIEKRWRLSDISNNLNLSEIAVRKRLESEKLTFQQILLDIRMHHAAKLLLNSQSYINDVSRLIGISSPSYFIRKFNEYYGITPKKFYLYHKKF
What is the function of this protein?
Primary regulator of plasmid-encoded virulence genes.  Activates the transcription of icsA (virG) and of virB, which is an activator of the ipaABCD virulence regulon (By similarity).
What are the official names of this protein?
Virulence regulon transcriptional activator VirF.
Protein: RL19_CLOB6
Sequence: MLEVIKAIEAEQVRSDLPEFNVGDTVKVHQKIKEGTRERVQVFEGTVLKRQNGGARETFTVRRVAYNVAVEKTFPVNSPLIEKIQVVRKGKVRRAKLYYLRDRVGKAAKVKERI
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ATPE_CITSI
Sequence: MTLNLCVLTPNRIVWDSEVKEIILSTNSGQIGVLPNHAPIATAVDIGILRIRFNDQWLTMALMGGFARIGNNEITILVNDAEKSSDIDPQEAQQTLEIAEANLRKAESKRQTIEANLALRRARTRVEVINAIS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, chloroplastic, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.