PharMolix/UniProtQA huggingface dataset:
Protein: RPOZ_LACJO
Sequence: MKITYPSIDKLLSRVNSRYSLSVLAAKRAHEIQAGAPLALKHYKSDKAVGEALEEIAAGKVTIDPEHREDIG
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: GLYA_LIMRD
Sequence: MNYGKKSPQLWAAIENEEQRQQDTIELIASENIVSDAVREAQGSVLTNKYAEGYPNKRYYGGCEFIDQVEQLAIDYAKKLFNAAYVNVQPHSGSQANMAVYQALLKPGDVILGMGMDAGGHLTHGATVNFSGKLYKTYGYGLNPDTEELDYDEIMALAKKVKPQLIVAGASAYSRIIDWQAFRKIADEVGAYLMVDMAHIAGLVATGTHPSPLPIADVVTTTTHKTLRGPRGGMILSKSTELGRKINSAVFPGIQGGPLEHVIAGKAQAFYEDLQPEYAEYIQQVVKNAQAMEKVFNTSKQIRVVSGKTENHLLVLDLTKTGLTGKDAQNLLDRVHITTNKEAIPNDPRSPFITSGLRIGTPAITSRGFKEEDAQKVAELISTALTNPTDEERLQEVAKGVHELTTKYPLN
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSP_BURM7
Sequence: MKLEHPDRLMNRTPLSLAALETHDAFAERHIGPDAASQQAMLDTLGFATRAALIDAVIPASIRRAETLPLGPFAQPKSEAEALAALRALADKNQVFRSYIGQGYYDTHTPAVILRNVLENPAWYTAYTPYQPEISQGRLEALLNFQQMVADLTGLEISNASLLDEATAAAEAMTLLQRVGKPQSNVFYVADDVLPQTLEVIKTRAKPIGIEVKSGPAADAAAANAFGVLLQYPGANGDVRDYRALADAIHAAGGHVVVAADILALTVLMPPGEWGADVAVGNTQRFGVPMGFGGPHAAYMAVRDEFKRQMPGRLVGVTVDAQGKPALRLALQTREQHIRREKATSNVCTAQALLAIMASMYAVYHGPRGLKTIALRVNRIAALLAAGIRHLGYATVNDTFFDTLTIDTGARTAQLHAFAQAKRINLRRAGDTRVGVSVDETTTRADLADLLTIFAQAAGATAPDIDALDAGLLPAPALPPSLERTSAYLTHHVFNRHHSETEMLRYLRSLSDKDLALDRSMIPLGSCTMKLNATSEMLPVTWPEFGRIHPFAPAEQTVGYREMIDQLEQMLVAATGYAAVSLQPNAGSQGEYAGLLIIHAYHESRGESHRDVCLIPASAHGTNPASAHMAGMKVVVVACDAQGNVDIADLKAKADAHSHDLAAIMITYPSTHGVFEQNVREICEIVHAHGGQVYVDGANMNAMVGLTAPGQFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVGPHLAKFLPNQRSTGYARGEDGIGAVSAAPYGSASILPISWMYIAMMGAKNLTAATETAILNANYIAKRLAPHYPVLYSGPGGLVAHECILDLRPIKDSSGITVDDVAKRLMDYGFHAPTMSFPVPGTLMVEPTESESQEELDRFIAAMIAIRDEIRAVEEGRADREDNPLRHAPHTAAVVTANEWPHAYSREQAAFPVASLVANKYWPPVGRADNAYGDRNLFCSCVPVSDYA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: TBB_TETTH
Sequence: MREIVHIQGGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGRYVPRAILMDLEPGTMDSVRAGPFGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQITHSLGGGTGSGMGTLLISKVREEYPDRIMETFSVVPSPKVSDTVVEPYNATLSVHQLVENADECMVIDNEALYDICFRTLKLTTPTYGDLNHLVSAAMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMIGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMCAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKSSICDIPPKGLKMAVTFVGNSTAIQEMFKRVAEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEEGEN
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: CRCB2_CLOAB
Sequence: MDYFLIGIGGACGSIVRYKIGDIISKRTKSKFPWGTFIINITGAFLLGIITKSGAGKNLSMILADGFLGAYTTFSTFMYEGFNLFENKKKLNALIYILSSIIIGILGFYMGEFISQL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NOC_BACAA
Sequence: MKNTFSRLFGFGDKESEFELQDESHEEIDKKVYEEIQEIPIVNITPNRYQPRTVFDDARIEELALTIRTHGLIQPIVVRQYEDDKYEIIAGERRFRAATKLGWEKVPAIIKNLNDTETASVALIENLQREELTAIEEAVAYQKLIELHNLTQEALAQRLGKGQSTIANKLRLLKLPEEIKSALLEKSITERHARALIPLKNEELQLKVLQEIVEKQLNVKQTEERITKLLEEAKPKRKAKQKAVSRDTRIAMNTIRQSLQMVADSGLNVNSEEEEFDEYYQITIQIPKKK
What is the function of this protein?
Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle.  It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage.
What are the official names of this protein?
Nucleoid occlusion protein, Noc.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: NOPC1_MOUSE
Sequence: MEFQGERGTGPGVSSSSVACSQVTVSRELLTAGSEGSGGIWDQLLISSKPHPRKTSTLQTVRMQRSPLLDQVQAFLPQMAQANEKLRREMAAAPAGHFNIENIDETSGNIIQMDVALFEMSRSDSKEEDSPEESSRDSSGDSSESEEDVCVPSEVTIENIKLPNAEGGKGKIEILDSPASKKKKQ
What is the function of this protein?
Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly.  Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2.
What are the official names of this protein?
NOP protein chaperone 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNPH_METSB
Sequence: MRPSQRAADELRPVTFERNVARYAEGSCLIKFGSTHVLCTASLEDKPPAWLRGQGRGWVSAEYAMLPRATHTRTKRESTTGKPSGRTQEIQRLIGRSLRAVTNLQGLGERQITIDCDVLQADGGTRTAAITGAWVALHDCLKWMRQRSIIKDLPLRDHVAAISCGVSNGESVLDLDYAEDSAAETDANFVITGSGSLVEVQATAEGAVFTETQLTAMLALARGGITTLVEMQKAAVA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: DRATY_PHYSA
Sequence: MAFLKKSLFLVLFLGLVSLSICDEEKRENEDEENQEDDEQSEMRRGLRSKIWLWVLLMIWQESNKFKKM
What is the function of this protein?
Atypical cationic antimicrobial peptide with potent activity against Gram-negative and Gram-positive bacteria (PubMed:16401077, PubMed:18637027).  Acts by inducing permeabilization of bacterial membrane (PubMed:16401077).  In vitro, also shows chemoattractant activity, which is mediated through a G protein-coupled receptor (probably FPR2 coupled to the ERK1/2 MAPK kinase pathway) (PubMed:18637027).  Has slow-kinetic self-association and amyloid-like properties that modulate its activity (PubMed:18637027, PubMed:24146759).  The soluble, weakly self-associated forms act on leukocytes to promote chemotaxis but have low antibacterial activity, the oligomers exhibit potent antimicrobial activity, whereas the amyloid-like fibrils have a very weak antibacterial activity (PubMed:18637027).  The membrane composition has a great influence on the peptide behavior (PubMed:24146759).  The peptide induces membrane leakage and insertion to a lesser extent in model membranes of the anionic lipid phospatidylglycerol (PG) than in the model membranes of the zwitterionic lipid phosphatidylcholine (PC) vesicles (PubMed:24146759).  It forms more fibrils in PC than in PG (PubMed:24146759).  Membrane perturbations are more observed in the presence of PG than in the presence of PC (PubMed:24146759).  The peptide shows low hemolytic activity (PubMed:16401077).
What are the official names of this protein?
Atypical cationic antimicrobial peptide, Dermaseptin-S9, DRS-S9.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: GAL1_YERPG
Sequence: MSLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRDDRQIRVIAADYENQQDIFSLDAPIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGNVPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVKALRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHISMRDDFEITVPPIDRLVEIVKSVIGDQGGVRMTGGGFGGCIIALMPLELVEQVRTTVAQEYPAHSGGKKETFYVCQASQGAGLC
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSE1_XENLA
Sequence: MADRINESHQRFLQALMSHGIMEGSAVRALHRHCCELHKVHYMHDKLDDFVGVLNRHLQPLFMTIEKGVGEEDGLTYYALVNRVENDITKMASDYAENELELFRKTMELIILSDNGFATSISILNLADELQSKKMKKKEVEQLLQSFVQEKWLIGRNGEYTLHTRCIMELEHYIRNTYQDVAKICNVCRKVAIQSQLCENCGIPLHLQCAGKYFHGKANPTCPNCNESWPHEIPDLNQVSSQGPSHSQTETVRGRNQRSKNTSTASRTSR
What is the function of this protein?
RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate.  Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex.  Involved in maintenance of genome integrity, DNA damage response and DNA repair.
What are the official names of this protein?
Non-structural maintenance of chromosomes element 1 homolog, Non-SMC element 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the NSE1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: NQRC_NEIMB
Sequence: MAKKFDKDSFSGTLIVVLAVSLICSVIVAGAVVGLKPIQEKQKLQDKQGYILSVAGLMDKDTDIGKTFAERIEQRVVDLATGEYVADAPKDFSARIAGKDPAQSIRIKTEDDLAGIKSRAKYTEVYLVKGEDGKIGQIILPMHGNGLWSVMYGFVAIQPDGNTINGITYYEQGETPGLGGEIGNPLWQQKFVGKKLFDGQGKLALHVGKGAGSDKEHGVDALSGASLTSKGVQGSFAYWFGENGYIPYLNKLKSAGAQ
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit C, Na(+)-NQR subunit C, Na(+)-translocating NQR subunit C, NQR complex subunit C, NQR-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the NqrC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RS13_CAUVC
Sequence: MARIAGVNIPTNKRVLIALQYIHGIGQKSAREIITKVGIEDARRVNQLTDAEVLQIRETIDRDYTVEGDLRRENSMNIKRLMDLACYRGLRHRKGLPVRGQRTHTNARTRKGPAKPIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: SYE_METS5
Sequence: MTMELEEIVYKYALWNAVKHNGQAQVGPVVSKVFAERPELKANAKEVVKLAEKMVAKVNAMSLEQQTAELQKYPELLEERKKEEKKTLSPLPNVKGTVVTRFAPNPDGPLHLGNARAAVLSFEYAKMYKGKFILRFDDTDPKVKKPIKEAYDWIRDDLRWLNITWDLEFKASERMSAYYNVAKVMLEKGFAYVDTLSDAEFKAWRDSRNKTVYKPRTNPPEVNLELWEKMLNGDFDEGKAVVRIKTNPEDPDPSKIDWVMLRIIDTKRNPHPIAGDKFRVWPTYNFATAVDDHEFGITHILRAKEHTTNTEKQRWVYDYMGWEMPTVLEFGRLKLEGFMMSKSKIRGMLETGSERDDPRLPTLAGLRRRGIIPDTVREIIIQVGLKVTDATISFDNIASVNRKLLDPVAKRLMFVREGVLFKLEIPQEMKAKVPLIPARQEFREIFVKPGDEIYLDKGDVEEGKVVRLMDLCNVKIEGDRLRFLSQDLESAKRMGANIIQWVKKSESKSVNVIKADPNKDVEEIRGYGEGYFETLKPGDIVQLVRYGFARVDSISRGEITMIFAHE
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRP72_POPTR
Sequence: MAGIQQQQLVNDTLPASLNGSSNRIASVNVEGQPQPWADDLDLQDPNHQKPGWRKFLSYVGPGFLVSLAYLDPGNLETDLQAGANHRYELLWVILIGLIFALIIQSLAANLGVSTGKHLSELCKTEYPKYVKYCLWLLAEISVIAADIPEVIGTAFALNILFHIPVWVGVLCTGCSTLVLLGLQKYGVRKLELLIAVLVFVMAACFFGEMSYVKPSATDVLKGMFIPKLSGQGATGDAIALLGALIMPHNLFLHSALVLSRKMPNSVRGINDACHYFLIESGFALFIAFLINLAVISVSGTVCSAQNLSSENADRCGDLTLNSASFLLQNVLGKSSSKIYAIALLASGQSSTITGTYAGQYIMQGFLELKMRKWIRNLVTRCIAIAPSLVVSIIGGSSGAGRLIIIASMILSFELPFALIPLLKFSSSTTKMGPHKNSIYIIVISWILGLGIIGINIYYLSTGFVGWLIDNNLPKVGNVFIAIIVFPLMAIYILAVIYLTFRKDSVVTFLGPNKNDPQQQANMENGLTKSTEGPEMERVPYRGDLADIPLPE
What is the function of this protein?
Probable divalent metal transporter.
What are the official names of this protein?
Metal transporter Nramp7.2, PotriNRAMP7.2, PtNRAMP7.2, Natural resistance-associated macrophage protein 7.2.
What is the protein family that this protein belongs to?
Belongs to the NRAMP (TC 2.A.55) family.
Protein: MTNC_LEPIC
Sequence: MNIKTFEFYLFDIEGTTTPIEFVHKILFPYSVEKFDSFFQSNLLEKEWIEKLILEGKNDTTYSGKLSDSAFDLSEYCKHLVSLDRKSGILKEIQGRIWKSGYENGELKSSMFSDVPSFLKKIQASKKKSAVYSSGSIQAQKLIFEYSDFGNLTHFFYAYFDTGVGGKRESSSYSKISEQLGVAPEKILFFTDIKEEADAAKEAKLHSAILERPGNYPQPQHSHFKISSFEGLNP
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: TRUA_METCA
Sequence: MRIALGIEYDGSGFAGWQWQNGKRTIQAEVERALSRVADAPVRVTCAGRTDAGVHAIEQVAHFDTESRRSERSWLLGANTALPEDVRILWVRETEPHFHARLSAIARYYRYEILNRPMRSALRPRQFTWCHAPLDVERMREGAAYLVGEHDFSSFRAQQCQSRSPFRRVHFLHVRREGERVIMEIAANAFVHHMVRNIAGVLMAVGAGKRDPAWVGELLAMRDRAKGGVTAPPDGLYLGGVCYPEEFGLARDAVFEHLPADARRYQPDDES
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: CAMKV_MOUSE
Sequence: MPFGCVTLGDKKNYNQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKEPCGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAVRVTTLMKRLRAPEQSGTAATQSASDAATPGAAGGAIAAAAAAAAAGGAASASGASATAATEGGAGCAAKSDDIASADRSATPATDGSATPATDGSVTPATDGSITPATDGSVTPATDRSATPATDGRATPATEESTVPATQSSALPAAKAAATPEPAVAQPDSTALEGATGQAPPSSKGEEATGCAQESQRVETS
What is the function of this protein?
Does not appear to have detectable kinase activity.
What are the official names of this protein?
CaM kinase-like vesicle-associated protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures (By similarity).
Protein: NMU_RANCA
Sequence: MQKGSEDTTQNRCHQHSIGGHSTCGLLLLIILVSWTSICEGAPFSSPVLGAEDELPLWNGIDDACSAVLPDPQLAVSSTLRELCFMVMRMQQKSQGEEKDDFKRFLFHYSKSHDSGNSDITSSVLHPLLQLLPQLHDRRMKRLTSDEEVQVPGGVISNGYFLFRPRNGRRSAGFR
What is the function of this protein?
Stimulates uterine smooth muscle contraction and causes selective vasoconstriction.
What are the official names of this protein?
Neuromedin-U.
What is the protein family that this protein belongs to?
Belongs to the NmU family.
What are the subcellular locations of this protein?
Secreted.
Protein: RRAAH_VIBVU
Sequence: MKDITPDICDQHEDKVTLLNLPLQNFGQKAAFFGEIVTVRCYHDNSKVRDVLSENGKGKVLVVDGHGSCQKALLGDQLAILAIENDWEGVIVFGAVRDVAQMSQMELGIKALGTSPFKTEKRGAGEVNVTLTMHNQMVQPKDYIYADWNGILISKELLQF
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: TREPH_PLESA
Sequence: MSTPHHQFESKSSTAIRRRLSSSVSSKQRPNIMTTTFASLTPMWAGVAGTLVNNNTQYEIAVTVHDGVYSTDFASVIIPVTPGDTVKNSKDIEAQVLNLIRKFSAEHLCKFLGAGITLALLKECPNLCTRLWLDMDIVPIVFNIKPFHTDSVTRPNIKHRISSTTGSYVPSGSETPTVYVEASHLGDPSHLSPNAAQKLPIPRTLDEQSDSAARKCLMYFGPNNNPRLSIGARNPVTVDAGGKIHLIDDLEEYRMTVGAGTWNAVIKLADELREKKVKIGFFSSTPQGGGVALMRHALIRFLTALDVDVAWYVPNPSPQVFRTTKNNHNILQGVAAPDLRLTQEAKDAFDAWILKNGLRWTAEGGPLAPGGVDVVFIDDPQMPGLIPLIKKVRPEVPIVYRSHIEIRNDLVHVAWSPQEEVWKYLWNNIQLADLFISHPVSKFVPSDVPTEKLALLGAATDWLDGLNKDLDPWDSPFYMGEFRPRGSHLNRGEFRSLCAKEKMHELNWPARDYIVQVARFDPSKGIPNVVDSYYKFRNLLRTRSPDMDESEHPQLLICGHGAVDDPDASIIYDQIMALVNSDPYKEYAHDIVVMRLPPSDELLNAMMANSRIALQLSTREGFEVKVSEALHTGKPVIACRTGGIPLQIQHGKSGYLTTPGEKDAVAGHFYDFYTDEALYRKMSDFARTHVSNEVGTVGNAAAWLYLAVMYSRGEKIKPNGAWINDFFREETGEPYKEGETKLPRTKLDMQG
What is the function of this protein?
Reversibly catalyzes the synthesis and degradation of trehalose from glucose and alpha-D-glucose 1-phosphate.  The equilibrium lies in the direction of trehalose synthesis.
What are the official names of this protein?
Trehalose phosphorylase, Trehalose synthase, TSase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: BRSK1_MOUSE
Sequence: MSSGSKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGSGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDGSSGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGTPPRSLQPPPGRSDPDLSSSPRRGPPKDKKLLATNGTPLP
What is the function of this protein?
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication.  Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1.  Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'.  Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons.  In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.  Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome.  Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
What are the official names of this protein?
Serine/threonine-protein kinase BRSK1, Brain-specific serine/threonine-protein kinase 1, BR serine/threonine-protein kinase 1, Serine/threonine-protein kinase SAD-B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Synapse. Presynaptic active zone. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity).