PharMolix/UniProtQA huggingface dataset:
Protein: RIP1_MYCTU
Sequence: MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGPTLWSTRRGETEYGVKAVPLGGFCDIAGMTPVEELDPDERDRAMYKQATWKRVAVLFAGPGMNLAICLVLIYAIALVWGLPNLHPPTRAVIGETGCVAQEVSQGKLEQCTGPGPAALAGIRSGDVVVKVGDTPVSSFDEMAAAVRKSHGSVPIVVERDGTAIVTYVDIESTQRWIPNGQGGELQPATVGAIGVGAARVGPVRYGVFSAMPATFAVTGDLTVEVGKALAALPTKVGALVRAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFFLAQLNLILAAINLLPLLPFDGGHIAVAVFERIRNMVRSARGKVAAAPVNYLKLLPATYVVLVLVVGYMLLTVTADLVNPIRLFQ
What is the function of this protein?
Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal (possibly oxidative stress) triggers a concerted proteolytic cascade to transmit information and elicit cellular responses.  The membrane-spanning regulatory substrate protein (includes anti-sigma factors RskA, RslA, RsmA, and PbpB in M. tuberculosis) is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this entry), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein (ECF sigma factors SigK, SigL and SigM).
What are the official names of this protein?
Zinc metalloprotease Rip1, Regulator of sigma KLM proteases, S2P endopeptidase, Site-2 protease Rip1, S2P protease Rip1, Site-2-type intramembrane protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RRAAH_STUS1
Sequence: MQYVTPDLCDAYPDLVQVVEPLFSNFGGRDSFGGEIVTIKCFEDNSLVKDQVDVDGTGKVMVVDGGGSLRRALLGDMLAEKAARNGWEGLIIYGCVRDVDVLAQTELGVQALASHPMKTDKRGIGDLNVPVTFCGVTFRPGEYVYADNNGIIVSPEPLSMPQ
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: NAGB_CROS8
Sequence: MRLIPLATPQQVGKWAARHIVKRINDFNPTADRPFVLGLPTGGTPLEAYKALIEMHKAGQVSFKHVVTFNMDEYVGLPKDHPESYHSFMYRNFFDHVDIPEENINLLDGNAPDIDAECRRYEEKIRAYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFGGDVNQVPKYALTVGVGTLLDAQEVMILVLGHVKAQALQAAVEGNVNHMWTISCLQLHPKAVIVCDEPSTMELKVKTLKYFTELEAENIKDL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: DML1_KLULA
Sequence: MREIINVSVSHRSNHLITQFYNCLEPLLHDADQENDVFLNPNIDKVSKTVSYTPRALLWDAKLGNGSLGTYQYVSENDYADTLDSEQGATAKTAHRVQTHDRIRKSPYQLALDQGATVLPKINDEIAKYWSDYSKLIYDPSSFNTLQDWYHDAANQQKAPNFQNLRQVYFDNYETGSNQFRENYSNEFFDSNLHQQLEKCDSLQGFNIITELDNGWGGFSSSMLLELKDELPKVSYHTYGWNQDDVCSLKEPVHSTKTKFQMLCNKIRATIALSQESDLFFPLYANTKEAFWRSTGETVLLFDSVNSVFHGSRKQAATNSNMRKMSHLTNALTLGESKRNIVSKLNVDEYNSFSFYDRMPLYKNSKKPSHTFTQCEIDRVNHKESSMFHFTTYPWTNSDTIPDTHHSCAESVIGVTEKPRDVLKTWEDLVSRYFRYDSDREEIKDHLGTLSLEYEHGWYDDDDSDLDL
What is the function of this protein?
Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
What are the official names of this protein?
Protein DML1.
What is the protein family that this protein belongs to?
Belongs to the misato family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CNEPA_DANRE
Sequence: MLKTRQCLLGIRTFLGVTSRIWSFFLYILRKHLRTIIQYQTVRYDILPLSPISRNRLNAVKRKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNNRGILKRRYYRQHCTLDLGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTSDVRSVLSRNLHQHRLW
What is the function of this protein?
Serine/threonine protein phosphatase that may dephosphorylate and activate lipins.  Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels.  May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics.  May also indirectly regulate the production of lipid droplets and triacylglycerol.  May antagonize BMP signaling (By similarity).
What are the official names of this protein?
CTD nuclear envelope phosphatase 1A, Serine/threonine-protein phosphatase dullard-A.
What is the protein family that this protein belongs to?
Belongs to the dullard family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Protein: RSMH_VIBVY
Sequence: MTDTFQHISVLLHESIDGLAIKPDGIYIDGTFGRGGHSRTILSKLGEHGRLYSIDRDPQAIAEAGKIDDPRFTIIHGPFSGMANYAEQYDLVGKVDGVLLDLGVSSPQLDDAERGFSFMKDGPLDMRMDPTSGIPVSQWLMEADLDDITWVIREFGEDKHARRIAKAIVAHREDETKEPLTRTSQLAKLISEAAPKSFKEKKHPATRAFQAFRIYINSELEEIDTALKGAASILAPEGRLSVISFHSLEDRMVKRFMRKESKGPEVPHGIPLTEAQIKALGSANMKTVGKAIMPTAQEIELNPRSRSSVLRIAEKL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_STRAW
Sequence: MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAETSEVRWEELPKPREIYEFLEGYVVGQEAAKKALSVAVYNHYKRVQAGENGGGQSREDAIELAKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLEKLIESRAGAKGIGFGATIRSKRELESKDQFEDVMPEDLVKFGMIPEFIGRLPVITSVHNLDREALLQILVEPRNALVKQYQRLFELDGVELDFEREALEAIADQAILRQTGARGLRAIMEEVLMSVMYEVPSRKDVARVVITADVVHSNVNPTLIPRDARGRGPGEQKTA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: SYY1_BACCR
Sequence: MGILQDLEFRGLINQQTDDEGFEQLLEKESVKLYCGFDPTADSLHIGHMYPVLMLRRFQLAGHQPIALVGGGTGMIGDPSGKKAERTLNTKDTVAYYTESIKNQLSNFLEFENVDNPATMANNYDWLGNLDVISFLRDIGKNFGLNYMLAKDTVASRLETGISFTEFSYMILQSYDFLNLYQHHKCRLQIGGSDQWGNITAGLELIRKSEEDAKAFGLTIPLVTKSDGTKFGKTEGGAIWLDPEKTTPYEFYQFWINTDDRDVVKYLKYFTFLSHEEILELEKQVAEAPEKRAAQKALGSEMTKLVHGEEALEQAIKISAALFSGSVAELTASEIEQGFKDVPSVERTAEDTVLIDLLVESKISPSKRQAREDVTNGAIYVNGERTQALDYVVTENDRIEGKFTIIRRGKKKYFLIRY
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase 1, Tyrosyl-tRNA synthetase 1, TyrRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB6_COLOB
Sequence: MGKVYDWFEERLEIQAIADDISSKYVPPHVNIFYCLGGITFTCFLLQVASGFAMTFYYRPTVAEAFASVQYIMTDVNFGWLIRSVHRWSASMMVLTMILHVFRVYLTGGFKKPRELTWVTGVILAVLTVSFGVTGYSLPWDQVGYWAVKIVTGVPDAIPVIGSPLVELLRGSVSVGQSTLTRFYSLHTFILPLLTAVFMLMHFLMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NRDR_ECO5E
Sequence: MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREPFNEEKLRSGMLRALEKRPVSSDDVEMAINHIKSQLRATGEREVPSKMIGNLVMEQLKKLDKVAYIRFASVYRSFEDIKEFGEEIARLED
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RL25_SHEON
Sequence: MSYTITAQTRTEIGKGSSRRLRHAGKVPAVIYGAGKEPVSIVFDHKDIINAQANDDFYTSVVTIVLDGKEVGVRAQAMQRHAFKPIIEHVDFVYA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: VP22_HHV2H
Sequence: MTSRRSVKSCPREAPRGTHEELYYGPVSPADPESPRDDFRRGAGPMRARPRGEVRFLHYDEAGYALYRDSSSDDDESRDTARPRRSASVAGSHGPGPARAPPPPGGPVGAGGRSHAPPARTPKMTRGAPKASATPATDPARGRRPAQADSAVLLDAPAPTASGRTKTPAQGLAKKLHFSTAPPSPTAPWTPRVAGFNKRVFCAAVGRLAATHARLAAVQLWDMSRPHTDEDLNELLDLTTIRVTVCEGKNLLQRANELVNPDAAQDVDATAAARGRPAGRAAATARAPARSASRPRRPLE
What is the function of this protein?
Tegument protein that plays different roles during the time course of infection (By similarity).  Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection (By similarity).  Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins (By similarity).  Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network (By similarity).  Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA.  Acts by mediating disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity (By similarity).
What are the official names of this protein?
Tegument protein VP22.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae VP22 tegument protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus. Note=One of the most abundant tegument protein (about 2000 copies per virion). Localizes in the cytoplasm at 8 hours postinfection and in the nucleus at 16 hours postinfection. During virion morphogenesis, this protein probably accumulates at the trans-Golgi where secondary envelopment occurs.
Protein: Y208_METBF
Sequence: MAFIGIDHGTTAMRFALIEGESTHTFELERAEAAAMSENEILTSLEEHFGIRRETINLIALTYSMGDGFSTIKDVRNLEGRGLKSIEGAGKKTGGGTRVFDAIRHSGVPAIAIPGLHTESKVDPRMKVFSHLTSPEKLGIAYHILCLGYNNFVVSDISSNTVTLAIADRKVIGAIDACIFAPGVHHGPLDLQAIRDVDNGYRTANKAFMEAGALKMTPYKDRDELLLAAEDEESPALLALDTISLFAAMEIASMQLLLKDYETIGEVFLAGSVGEFEYVQKKIRAHLGQECQCLGKWHAAIGCAEIARDVFAGEKEILGVEVNYP
What are the official names of this protein?
UPF0285 protein Mbar_A0208.
What is the protein family that this protein belongs to?
Belongs to the UPF0285 family.
Protein: ATPG_STRPF
Sequence: MAGSLSEIKAKIISTEKTSKITSAMRMVSSAKLVKSEQAARDFQIYASKIRQITTDLLKSELTIGSDNPMLVSRPVKKTGYIVITSDKGLVGGYNSKILKSVMDMITEYHADGDYEIISIGSVGSDFFKARGMNVAFELRGLADQPSFEQVRQIISQSVDMFVNEIFDELYVCYNHHVNSLTSQVRVQQMLPISDLVADEAAEEGVTGFELEPNRHDILDQLLPQFTESLIYGAIIDAKTAEHAAGMTAMQTATDNAKNVINDLTIQYNRARQAAITQEITEIVAGANALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CXXC4_XENLA
Sequence: MHRNDSQRLGKPGGAPESLQMANNNFLSTLSPEHCRPLAGECMNKLKCGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLADCPQNNSSGAGGNPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQICKFRKCEELKKKPGTSLEVRGDDSFFPCLASSLIPPFSPPFQCFLSPFKMHHSFSESPSRL
What is the function of this protein?
Acts as a negative regulator of the Wnt signaling pathway required for anterior neural structure formation (PubMed:15108311, PubMed:11113207).  Ectopic expression induces ventralization(PubMed:15108311, PubMed:11113207).  Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).
What are the official names of this protein?
CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein, xIdax.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOCK2_HUMAN
Sequence: MAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSVISLFHAHEEATDKITERIKEEMSKDQPDYAMYSRISSSPTHSLYVFVRNFVCRIGEDAELFMSLYDPNKQTVISENYLVRWGSRGFPKEIEMLNNLKVVFTDLGNKDLNRDKIYLICQIVRVGKMDLKDTGAKKCTQGLRRPFGVAVMDITDIIKGKAESDEEKQHFIPFHPVTAENDFLHSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLHDGFHDLVVLKGDSKKMEDASAYLTLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKWRMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHSQSDEYDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKALEYVFKFIVRSRTLFSQLYEGKEQMEFEESMRRLFESINNLMKSQYKTTILLQVAALKYIPSVLHDVEMVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIVQSNLFKKQECRDILLPVITKELKELLEQKDDMQHQVLERKYCVELLNSILEVLSYQDAAFTYHHIQEIMVQLLRTVNRTVITMGRDHILISHFVACMTAILNQMGDQHYSFYIETFQTSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQRFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTMLASKSAEEGKQIPDSLSTDL
What is the function of this protein?
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines.  Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP.  May also participate in IL2 transcriptional activation via the activation of RAC2.
What are the official names of this protein?
Dedicator of cytokinesis protein 2.
What is the protein family that this protein belongs to?
Belongs to the DOCK family.
What are the subcellular locations of this protein?
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin.
Protein: RL4B_ARATH
Sequence: MVASAAARPLVTVQGLDGDMSTDQSTTVTLPDVMTAPVRPDIVNFVHAQISNNSRQPYAVSKKAGHQTSAESWGTGRAVSRIPRVPGGGTHRAGQAAFGNMCRGGRMFAPTKIWRRWHRRVNVNMKRHAIVSAIAATAVPALVMARGHKIENVPEMPLVVSDSAEAVEKTSAAIKVLKQIGAYDDAEKAKNSIGIRPGKGKMRNRRYISRKGPLVVFGTEGAKIVKAFRNLPGVELCHVERLNLLKLAPGGHLGRFVIWTKSAFEKLESIYGSFEKPSEKKKGYVLPRAKMVNADLARIINSDEVQSVVNPIKDGSKRAVLKKNPLKNLNVMFKLNPYAKTAKRMSLLAEASRVKAKKEKLEKKRKVVTKEEAQAIKAAGKAWYQTMISDSDYTEFDNFTKWLGASQ
What are the official names of this protein?
60S ribosomal protein L4-2, L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: TIP39_HUMAN
Sequence: METRQVSRSPRVRLLLLLLLLLVVPWGVRTASGVALPPVGVLSLRPPGRAWADPATPRPRRSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP
What is the function of this protein?
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation.  Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization.  May inhibit cell proliferation via its action on PTH2R activation.  Neuropeptide which may also have a role in spermatogenesis.  May activate nociceptors and nociceptive circuits.
What are the official names of this protein?
Tuberoinfundibular peptide of 39 residues, TIP39, Parathyroid hormone 2.
What is the protein family that this protein belongs to?
Belongs to the parathyroid hormone family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS18_FRAT1
Sequence: MSRRKVCRFTVEGVKEIDYKDVNKLKAYITETGKIVPSRVTGTSAKYQRQLATAIKRARFLALLPYCDRHFN
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RF3_SHIBS
Sequence: MTLSPYLQEVAKRRTFAIISHPDAGKTTITEKVLLFGQAIQTAGTVKGRGSNQHAKSDWMEMEKQRGISITTSVMQFPYHDCLVNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDAAKGVEDRTRKLMEVTRLRDTPILTFMNKLDRDIRDPMELLDEVENELKIGCAPITWPIGCGKLFKGVYHLYKDETYLYQSGKGHTIQEVRIVKGLNNPDLDAAVGEDLAQQLRDELELVKGASNEFDKELFLAGEITPVFFGTALGNFGVDHMLDGLVEWAPAPMPRQTDTRTVEASEDKFTGFVFKIQANMDPKHRDRVAFMRVVSGKYEKGMKLRQVRTAKDVVISDALTFMAGDRSHVEEAYPGDILGLHNHGTIQIGDTFTQGEMMKFTGIPNFAPELFRRIRLKDPLKQKQLLKGLVQLSEEGAVQVFRPISNNDLIVGAVGVLQFDVVVSRLKSEYNVEAVYESVNVATARWVECADAKKFEEFKRKNESQLALDGGDNLAYIATSMVNLRLAQERYPDVQFHQTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GALE_MOUSE
Sequence: MEKVLVTGGAGYIGSHTVLELLEAGYSPVVIDNFHNAIRGEDSMPESLRRVQELTGRSVEFEEMDILDQAALQHLFKKHSFKAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMRAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCRADTAWNAVLLRYFNPIGAHASGRIGEDPQGIPNNLMPYVSQVAIGRREALNVFGDDYATEDGTGVRDYIHVVDLAKGHIAALKKLKEQCGCRTYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAHEELGWTAALGLDRMCEDLWRWQKQNPSGFGAQA
What is the function of this protein?
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.  The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate.  It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited.  Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
What are the official names of this protein?
UDP-glucose 4-epimerase, Galactowaldenase, UDP-N-acetylglucosamine 4-epimerase, UDP-GlcNAc 4-epimerase, UDP-galactosamine 4-epimerase, UDP-GalNAc 4-epimerase, UDP-galactose 4-epimerase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: SYGB_ECOLI
Sequence: MSEKTFLVEIGTEELPPKALRSLAESFAANFTAELDNAGLAHGTVQWFAAPRRLALKVANLAEAQPDREIEKRGPAIAQAFDAEGKPSKAAEGWARGCGITVDQAERLTTDKGEWLLYRAHVKGESTEALLPNMVATSLAKLPIPKLMRWGASDVHFVRPVHTVTLLLGDKVIPATILGIQSDRVIRGHRFMGEPEFTIDNADQYPEILRERGKVIADYEERKAKIKADAEEAARKIGGNADLSESLLEEVASLVEWPVVLTAKFEEKFLAVPAEALVYTMKGDQKYFPVYANDGKLLPNFIFVANIESKDPQQIISGNEKVVRPRLADAEFFFNTDRKKRLEDNLPRLQTVLFQQQLGTLRDKTDRIQALAGWIAEQIGADVNHATRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEAEDVAVALNEQYQPRFAGDDLPSNPVACALAIADKMDTLAGIFGIGQHPKGDKDPFALRRAALGVLRIIVEKNLNLDLQTLTEEAVRLYGDKLTNANVVDDVIDFMLGRFRAWYQDEGYTVDTIQAVLARRPTRPADFDARMKAVSHFRTLDAAAALAAANKRVSNILAKSDEVLSDRVNASTLKEPEEIKLAMQVVVLRDKLEPYFTEGRYQDALVELAELREPVDAFFDKVMVMVDDKELRINRLTMLEKLRELFLRVADISLLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAAA_METJA
Sequence: MIVILDNGGQYVHRIHRSLKYIGVSSKIVPNTTPLEEIESNKEVKGIILSGGPDIEKAKNCIDIALNAKLPILGICLGHQLIALAYGGEVGRAEAEEYALTKVYVDKENDLFKNVPREFNAWASHKDEVKKVPEGFEILAHSDICQVEAMKHKTKPIYGVQFHPEVAHTEYGNEILKNFCKVCGYKFE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit A, Glutamine amidotransferase.
Protein: RPOA_SYNY3
Sequence: MAQFQIECVESSTRKNQQQYSKFSLEPLDRGQGTTVGNALRRVLLSNLPGAAVTAIRIAGVNHEFATILGVREDVLEIMLNMKELVLKSYTDQPQIGRLTAIGPGTVTAAQFEVPSEVEVIDPNQYIATLAEGAKLEMEFRVERGVGYRVIERGKDENSSLDFLQIDSVFMPVTKVNYTVEDIRADGMSPKDRLILDIWTNGSIQPREALSEASDIIANLFIPLKDLNELEAAHSDYQDEVNPESQIPIEELQLSVRAYNCLKRAQINSVADLLEYSQEDLLEIKNFGLKSAEEVIEALQKRLGITLPHEKAKA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: SUSE_BACTN
Sequence: MKKISNILLAVTFALPLFTACETDNDSNPILNEPDTFTLNTPAYAANNVYDLKNAQTVELTCSQPDYGFPAATTYTVQASFEQDFIEATDESKANYTVLESTSPTAKINVDASELNNALLDLWTAVNGEQAELPTEPVAVYIRLKANITSSGKGVCFSNVIELPNVLISKSTSSLTPPKTMFIVGSMLDTDWKVWKPMAGVYGMDGQFYSMIYFDANSEFKFGTKENEYIGINDNRVTVTDKAGAGVSGSDNFVVENAGWYLFYVKAAVKGDDYQFTITFYPAEVYLFGNTTGGSWAFNDEWKFTVPATKDGNFVSPAMTASGEVRMCFKTDLDWWRTEFTLHDGEIFYRDFNLIDSWTEKGDGYSIQGSAGNVIHLNFTAGTGEKK
What is the function of this protein?
Starch-binding protein present at the surface of the cell.  Mediates starch-binding before starch transport in the periplasm for degradation.  SusE and SusF do not constitute the major starch-binding proteins in starch degradation pathway.  Has higher affinity for starch compared to SusF.
What are the official names of this protein?
Outer membrane protein SusE, Starch-utilization system protein E.
What is the protein family that this protein belongs to?
Belongs to the SusE family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.