PharMolix/UniProtQA huggingface dataset:
Protein: CLPX_RHIME
Sequence: MSKVSGSNGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKTSMVKSRDGVPTPQEIIKVLDEYVIGQQQAKRILSVAVHNHYKRLAHAAKSSDVELAKSNIMLVGPTGCGKTYLAQTLARIIDVPFTMADATTLTEAGYVGEDVENIILKLLQAADYNVERAQRGIVYIDEVDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLDKIISARGEKTSIGFGATVRAPEDRRVGEVLRELEPEDLVKFGLIPEFIGRLPVLATLEDLDEDALIQILSEPKNALVKQYQRLFEMEDVELNFHEDALREIARRAIVRKTGARGLRSIMEKILLDTMFELPTLEGVREVVISDEVVKGTARPLYIYSERSEEKTNVSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: V29K_TRVTC
Sequence: ACDNCSVAQYKVEYSISTQENVLDVWKVGCISEGVPVCDGTYPFSIEVSLIWVATDSTRRLNVEELNSSDYIEGDFTDQEVFGEFMSLKQVEMKTIEAKYDGPYRPATTRPKSLVSSEDVKGASKKKNSS
What are the official names of this protein?
29 kDa protein.
Protein: XPT_BACCR
Sequence: MKVLQEKILNEGKVLSGDVLKVDAFLNHQIDPVLMQEIGKEFAKRFKEENITKIVTIESSGIAPAVMAALELGVKVIFARKRKSLTLQDNMYVANVYSFTKQETNEISLSRNHIDENDRVLIIDDFLANGQAALGLMSLVEQAGASIAGIGIVIEKAFQDGGKKLREQGVRVESLAEIASLDNGTVTFVQQETAEVK
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_LIMRJ
Sequence: MSSVVIVGSQWGDEGKGKMTDYLSQEADVVVRSQGGNNAGHTIAFDGKKFALRLVPSGIFAKDKLAVIGNGVVINPPALLKELHYLQDNGIDISGLRISSRSHITFPYHILLDKCQEEAKGDHKVGTTKNGIGPTYMDKVSRVGIRMCDLLEKDTFKEKLERNLAEKNELFTKLYHVDPISFDDIFESYYEYGQELKQYVTDTAQIVNDALDQDKKVLFEGAQGVMLDVDQGTYPYVTASNPIAGGVCTGVGVGPNKIETVVGICKAYSTRVGAGPFPTELTDEIGDQIRETGHEYGTVTGRPRRVGWFDSVAMRHARRVSGISCLSLNLLDVLTGLKTVKICTSYKLDGKQIDYYPASLKELERCEPVYEELPGWDEDITGAKKFEDLPINAQNYLKRVSELSESPLATVSVGADRIQTIIVKDPWEFAHK
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAA_SALTY
Sequence: MSIKEQSLMTPYLQFDRSQWAALRDSVPMTLTEDEIAQLKGINEDLSLEEVAEIYLPLSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRRVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPVYSHLIYDVIPEGDKTVAQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEELLQTWYINRFLKFREGAFTDPDSYFHNYAKLSKEEAVNTATSLWKEINWLNLKQNILPTRERASLIMTKSANHAVEQVRLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTGA_HAEIE
Sequence: MKKTKRIFTALSHLFSPKWWKKNWQRVVLLFFFAVFALLLIFRFVPIPFSAYMVQQKIANLLQGDFRYQIQYDWVSLENISPNIQLAVISSEDQRFPEHLGFDFEAIQRAIRYNEKSNKGIRGASTISQQTAKNLMLWHGQNWLRKGLEVPATMLLELTWSKKRILEVYLNIAEFGNGIFGVEAASRYYFKKSAKNLSQNEAALLVAVLPNPIIYKVNKPSLLVRKKTSLDFETNGKFRY
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NODE_RHILV
Sequence: MDRRVVITGLGGLCGLGTDASSIWTEMREGRSAIGPISNSEIHELKGMIGTEIKVLPQHDIDRKQLISMDRFSLLAVLAAKQAMLQAGLSCNEGNAHRFGATVGVGFGGWDATEKAYRTLLLGGATRTELFTGVKAMPSAAACQVSMNLGLRGPVFGATSACASANHAIASAVDQIKLGRADVMLAGGSDAPLVWIVLKAWEAMRVLAPDTCRPFSADRKGLVLGEGAGMAVLESYEHAAARGATMLAEVAGIGLSADAYHIAAPAVHGPEAAMRACLVDASLNAEDVDYLNAHGTGTKANDQIETTAIKRVFGDHARSMSISSTKSTHAHCLGAASALEMIACVMAIQEGVVPPTANYREPDPDCDLDVTPNVPRERKVRVAMSNAFAMGGMNAVLAFKQVP
What is the function of this protein?
Proposed to synthesize NOD factor fatty acyl chain.  Involved in the synthesis of a highly unsaturated fatty acid moiety, which forms part of a lipo-oligosaccharide that is responsible for host specificity.
What are the official names of this protein?
Nodulation protein E, Host-specificity of nodulation protein B.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: 212L_IIV6
Sequence: MNKITFMGVELEEQGPSDLIVKALGKSIKLMDLETFIDTTGFEKDPIMNDYFWQIMVTKQRTHLSAMLLQCLGYEGEFRVQQQHFKRFLKSNNIHPLELTSSDPDIKNYPTIQDEMKLLKPNVISNRKWLIVEPREFKKVIMKLNTKHGDRIREYYLCLEELLRLYLEYCVYFKEREAKLQITTLEQKLEQMNITMIEMKEEMNLSMEEHADKLDTLVDQNEELKLDVSEANEKLETVTHKLGIAVEDRSPRLEQKPLRERFVLFKRNVKNARFQYYAIRGQSIYVNGRLTLYNERYPNLEIIIDIFCQPNPRNLFLRFKNYVKDDERFNFAGNNVECDITYESIMKEIFEKLNEEKRNV
What are the official names of this protein?
Putative MSV199 domain-containing protein 212L.
Protein: MSRQ_SALHS
Sequence: MRLTAKQITWLKVCLHLAGFLPLLWLFWAINHGGLSADPVKDIQHFTGRTALKFLLATLLVSPLARYAKQPLLIRTRRLLGLWCFVWATLHLTSYALLELGIHNLALLGSELISRPYLTLGIISWLVLLALTLTSTQFAQRKLGKRWQTLHNVVYLVAILAPIHYLWSVKILSPQPVIYAALALALLALRYRKFRQWWR
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TX43A_ETHRU
Sequence: MAAIRNLLILTMLLIVCVSWNADAAPGAAPSIALDKRANENFSLREQEQPICEHCWKQPPPRRCPKFCLE
What are the official names of this protein?
U-scoloptoxin(04)-Er3a, U-SLPTX(04)-Er3a.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-04 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS4_BURVG
Sequence: MARYIGPKAKLSRREGTDLFLKSARRSLADKCKLDSKPGQHGRTSGARTSDYGTQLREKQKVKRIYGVLERQFRRYFAEADRRKGNTGENLLQLLESRLDNVVYRMGFGSTRAEARQLVSHKSITVNGVVANVPSQQVKAGDVIAIREKAKKQARIIEALSLAEQGGMPSWVAVDAKKFEGTFKQMPERADIAGDINESLIVELYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: DTD_SHESM
Sequence: MIALIQRVSRASVVVDNQTIGAIDKGLLVLLGVEREDNREKMEKLATKVMSYRVFSDENGKMNLNLTQAGGSLLVVSQFTLAADTGRGLRPSFSGAGTPEQALGLYEEFVAFCRAQGVTTETGQFGADMKVELVNDGPVTFNLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y037_ROSDO
Sequence: MSETEVVFDRRMLEALICPRSHETLKYDQERQELISETANLAYPIRNGIPVMLIDEARVLD
What are the official names of this protein?
UPF0434 protein RD1_0037.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: TYB4_XENLA
Sequence: MSDKPDMAEIEKFDKAKLKKTETQEKNPLPSKETIEQEKQTSES
What is the function of this protein?
Plays an important role in the organization of the cytoskeleton.  Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
What are the official names of this protein?
Thymosin beta-4, T beta 4, Thymosin beta 4Xen.
What is the protein family that this protein belongs to?
Belongs to the thymosin beta family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: YKR4_CAEEL
Sequence: MSEAPKRSEKSADYKKAVAKQRRIKKLRKMKIKDRAGDVVVSDISDVEVVGNGDEESQDDWLNDLLKSDGDGGKAGPVDPSHPMETTTTDHSSQNTLASKICAFTYDNSALLGVGIVTVALSIFARLRK
What are the official names of this protein?
Uncharacterized protein C06G4.4.
Protein: FOLD_CHESB
Sequence: MVQIIDGKAVAATILEKVTRETQDLKANGVTPGLAVVIVGEDPASQVYVASKGRKATECGFHSVQHSLPENTSEEELVSLVEALNRDPAIHGILVQLPLPKQIDSERIIHTIAPEKDVDGFHILNVGMLGTGAVTKALVPCTPAGAMLLIEGVRGKDLSGLSAVVIGRSNIVGKPMANLLLAANATVTIAHSRTADLPAACRGADILVAAVGRPEMVKGDWIKPGATVIDVGVSRIPAPEKGEGKMKLVGDVAYAEAEKVAGAITPVPGGVGPMTIAMLMANTLAAASKASGRDLPAF
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SUV39_DROME
Sequence: MATAEAQIGVNRNLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLERLSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYETYIAKITTELEKQLEALPLMENITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCGRDNCRKVLF
What is the function of this protein?
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate.  H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones.  Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions.  Involved in heterochromatic gene silencing including the modification of position-effect-variegation.
What are the official names of this protein?
Histone-lysine N-methyltransferase Su(var)3-9, Histone H3-K9 methyltransferase, H3-K9-HMTase, Lysine N-methyltransferase 1, Protein suppressor of variegation 3-9.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Protein: LEUD_ACIBS
Sequence: MKAYTVEQGIVAPLDRANVDTDLIIPKQFLKSIKRTGFGDNLFDELRYLDEGYPGQDNSVRPKNPDFVLNQPRYQGATVLIARTNFGCGSSREHAPWALNEYGFRTVIAPSFADIFFNNCFKNGMLPVILPEDIVDQLFKECAAQEGYQLTIDLAAQEVRTPTGEAFKFEVDPFRKHCLLNGLDDIGLTLQNADAIRAYEEKTKQVRPWVFQEIN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: DUS23_HUMAN
Sequence: MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHRLRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK
What is the function of this protein?
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues.  In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro.  Able to enhance activation of JNK and p38 (MAPK14).
What are the official names of this protein?
Dual specificity protein phosphatase 23, Low molecular mass dual specificity phosphatase 3, LDP-3, VH1-like phosphatase Z.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.
Protein: P21_GLRV3
Sequence: MEFRPVLITVRRDPGVNTGSLKVIAYDLHYDNIFDNCAVKSFRDTDTGFTVMKEYSTNSAFILSPYKLFSAVFNKEGEMISNDVGSSFRVYNIFSQMCKDINEISEIQRAGYLETYLGDGQADTDIFFDVLTNNKAKVRWLVNKDHSAWCGILNDLKWEESNKEKFKGRDILDTYVLSSDYPGFK
What are the official names of this protein?
Protein P21, 21 kDa protein.
Protein: ORF6_SPV4
Sequence: MKLSKKKMQRIDNTLEKLFEWSHLNGYDNWLTNQLALEKEIEQGYRCETCKLVIKSVNKDEIVCKCINEKR
What are the official names of this protein?
Uncharacterized protein ORF6.
Protein: COAE_TREPA
Sequence: MREFCPLIGVIGRSGAGKNVVSRLLAERGCYCIDADARTRELLESYGDSIVERFQVAAAARGLSLRRKDGGLHSAHLGVLLFSEPKLLQQHEEFLLPKVTRLLCEDIARAQAARPKAIVLNAPTLHKTELLQACSFVLYIWAPSILRMWRCKKRERVSFTHLLRRFSAQKGFYAQSIAQNADTYTVANCGRVASLARKVDCILTRRGVLGE
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PE192_ARATH
Sequence: MANDTHTDDLDELLDSALDDFKDLNLTQRNGGVKKEEGDKKETESLPSGVQGLGMGLPDMRSKKKGKKKIAKEDHVTEALDKLREQTRETVKGLESLSSKQQPTGSDDAMVEDWIKQFENLTGSNDLESIVDTMMQQLLSKDILHEPMKEIGARYPKWLEEHESSLNKEEFDRYSRQYELIKELNLVYENEPNNSTKIMEIMQKMQECGQPPSDIVQEMDPGFDFASLGQMSPDMLESSPNCCVM
What is the function of this protein?
Contributes to morphology determination of peroxisomes, but not to import of peroxisomal matrix proteins.  Required for proper post-translational import and stabilization of peroxisomal membrane proteins (PMPs).  Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane.  Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer.
What are the official names of this protein?
Peroxisome biogenesis protein 19-2, Peroxin-19-2, AtPEX19-2, Peroxisomal membrane protein import receptor PEX19-2.
What is the protein family that this protein belongs to?
Belongs to the peroxin-19 family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Lipid-anchor. Note=Predominantly cytoplasmic.
Protein: DNAA_YERE8
Sequence: MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNDFCGSEVPLLRFEVGSKPAVRAHSHPVTASVSAPVAPVTRSAPVRPSWDSSPAQPELSYRSNVNPKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKANAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHPE_STRCO
Sequence: MKNLKKAAAVTMVAGGLIAAGAGMASATDGGAHAHGKAVGSPGVASGNLVQAPIHIPVNAVGNSVNVIGVLNPAFGNLGVNH
What is the function of this protein?
One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins (PubMed:12832396, PubMed:12832397, PubMed:15228525, PubMed:17462011).  Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation (PubMed:17462011).  Chaplins are also involved in cell attachment to a hydrophobic surface (PubMed:19682261).  Forms amyloid fibrils in vitro probably composed of stacked beta-sheets, at low extracellular concentrations individually restores the ability to form aerial hyphae to a chaplin-deficient strain, but does so less well than other short chaplins (PubMed:21526199).  A small chaplin extract (ChpD, ChpE, ChpF, ChpG and ChpH) self-assembles into 2 different amyloids; small fibrils at the air-water interface form an amphipathic membrane that resembles spore-surface structures involved in aerial hyphae formation, and hydrophilic fibrils in solution that resemble the fibers that attach cells to a hydrophobic surface.  At the air-water interface the hydrophilic surface is in contact with water (probably equivalent to the peptidoglycan layer), while the hydrophobic face is exposed to the air, making the surface of the aerial hyphae hydrophobic (PubMed:24012833).  A minimal chaplin strain capable of forming aerial mycelium/hyphae on minimal medium contains ChpC, ChpE and ChpH.  The strain also has restored rodlet formation on the hyphae surface.  A second strain with ChpA, ChpD and ChpE makes slightly less robust hyphae.  This essential chaplin may coordinate the assembly and/or polymerization of the other chaplins (PubMed:18586935).  A small chaplin extract applied to a chaplin-deficient strain restores aerial hyphae formation (PubMed:12832396, PubMed:12832397).  The small chaplin extract forms an amyloid-like structure similar to that seen on the surface of cells without rodlets (rdlA-rdlB deletions), and is highly surface active, reducing surface tension from 72 to 26 mJ/m(2), which probably allows escape of hyphae from an aqueous environment into air (PubMed:12832396).
What are the official names of this protein?
Chaplin-E.
What is the protein family that this protein belongs to?
Belongs to the chaplin family. Short chaplin subfamily.
What are the subcellular locations of this protein?
Cell surface. Secreted, cell wall. Fimbrium.
Protein: LST_NEIGO
Sequence: MGLKKVCLTVLCLIVFCFGIFYTFDRVNQGERNAVSLLKDKLFNEEGKPVNLIFCYTILQMKVAERIMAQHPGERFYVVLMSENRNEKYDYYFNQIKDKAERAYFFYLPYGLNKSFNFIPTMAELKVKSMLLPKVKRIYLASLEKVSIAAFLSTYPDAEIKTFDDGTNNLIRESSYLGGEFAVNGAIKRNFARMMVGDWSIAKTRNASDEHYTIFKGLKNIMDDGRRKMTYLPLFDASELKAGDETGGTVRILLGSPDKEMKEISEKAAKNFNIQYVAPHPRQTYGLSGVTALNSPYVIEDYILREIKKNPHTRYEIYTFFSGAALTMKDFPNVHVYALKPASLPEDYWLKPVYALFRQADIPILTFDDKN
What is the function of this protein?
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to the terminal galactose residue of the lacto-N-neotetraose branch of surface lipooligosaccharide (LOS), forming an alpha-2,3-sialyl linkage.  Thus, functions in the sialylation of LOS, which plays a role in the evasion of the host immune response by protecting N. gonorrhoeae from complement-mediated serum killing and from phagocytic killing by neutrophils, and which is critical for establishing infection.
What are the official names of this protein?
N-acetyllactosaminide alpha-2,3-sialyltransferase, CMP-N-acetylneuraminate:beta-galactoside alpha-2,3-sialyltransferase, CMP-Neu5Ac:beta-galactoside alpha-2,3-sialyltransferase, Lipooligosaccharide sialyltransferase, LOS sialyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 52 family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein; Extracellular side. Note=Is exclusively found in outer membrane preparations of the pathogen and is surface exposed. Inner membrane, periplasmic, cytoplasmic, and culture supernatant fractions are devoid of Lst.
Protein: SYM_METPP
Sequence: MPRQLFVTTALPYANGHFHIGHIMEYIQADIWVRFQRMQGHAVHFVGADDAHGAPIMIAAEKAGKTPQQFVADIAAGRKPYLDGFHIAFDNWHSTDGPENHQLAQDTYRALRRNGLIFTREIEQFFDPVKAMFLPDRYIKGECPKCGAKDQYGDSCEVCGAVYAPTELKNPYSTLTGATPVMKTSEHHFFQLSSPRCLDFLKDWTHGSAPISGQPRLQAEVLNKIKEWFATDEQGHGGLADWDISRDAPYFGIEIPDAPGKYFYVWLDAPIGYLASLKNYFDKQGLDFEAFMADPKTEQVHFIGKDITYFHTLFWPAMLHFSGRRTPDHVFVHGFITVSGEKMSKSRGTGISPLRYLEIGMNAEWLRYYIAAKLNGRVEDVDFNPDDFVARVNSDLVGKYINIASRAAGFLSKRFDGRLTAELPAESRTLLEGLQAARDDIARLYEDREYAKALREAMALADRVNEYVDANKPWELAKQAGQDARLQQVCSTCIEAFRLLTIYLKPVLPALAAQVEGFLKVEPMRFADAGRLLGAHAISEYKHLMQRVDPKLLDALFEPPAEPSPQTSPAAAGAGAVPGGEALAPTITIDDFTKIDLRLAQIVDAALVEGSTKLLRLSLDVGEGRHRTVFSGIQSAFKPADVIGKFTVVVANLAPRKMKFGLSEGMVLAASHADEKTHPGLYLLEPTPGAVPGLRVR
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_RHOBA
Sequence: MKIVLQRSQHASVSVDGKIVGQIERGLVALIGIGHEDTEATASALADKTAGLRIFSDDNGKMERNVIDAGGDVLAISQFTLLADCRKGRRPAFTDAAPPDRANELYEHYVSELRKTGLSVPCGIFAADMAVSLTNDGPVTIILEL
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BACR2_HALS2
Sequence: MDPIALQAGFDLLNDGRPETLWLGIGTLLMLIGTFYFIARGWGVTDKEAREYYAITILVPGIASAAYLAMFFGIGVTEVELASGTVLDIYYARYADWLFTTPLLLLDLALLAKVDRVTIGTLIGVDALMIVTGLIGALSKTPLARYTWWLFSTIAFLFVLYYLLTSLRSAAAKRSEEVRSTFNTLTALVAVLWTAYPILWIVGTEGAGVVGLGIETLAFMVLDVTAKVGFGFVLLRSRAILGETEAPEPSAGADASAAD
What is the function of this protein?
Light-driven proton pump.  It may interact with bacterioruberin in the claret membrane.
What are the official names of this protein?
Archaerhodopsin-2, AR 2.
What is the protein family that this protein belongs to?
Belongs to the archaeal/bacterial/fungal opsin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.