PharMolix/UniProtQA huggingface dataset:
Protein: AVPI1_MOUSE
Sequence: MGTPASVVSEPPLWQVSTPQTRGRKQASANIFQDAELVQIQGLFQRSGDQLAEERAQIIWECAGDHRVAEALRRLRRKRPPKQNHCSRLRVPEPGSTASDPQASTTDTASSEQSGNSRRTSARAPRNWNKPGPTGYLHQIRH
What is the function of this protein?
May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.
What are the official names of this protein?
Arginine vasopressin-induced protein 1, AVP-induced protein 1, Arginine vasopressin-induced transcript 32 protein, VIP32, VIT32.
Protein: FTSZ2_PYRHO
Sequence: MVFDKLLEQAGINLEFEDKEIKDSDYLGDVSDLIKIAVIGVGGSGNNTISRLYDLGVQGADLIAMNTDAQHLHQIKAHKKLLLGKSITHGKGSGGDPRIGYRAAEASASEIADIVKDYDLIFLTAGMGNGTGTGATPVIARIIKETARNNGLPQEPLVISVVTFPFKMEGKVRIEKAKAGIEMLLEYSDTVIIIQNDKLIELVPKLPIQVAFRFADEIIARMVKGIVETIKLPSMVNIDYADIYSVMKGGGPALIGIGESDSNNRAVDAVMEALNNKMLDIEFGSGDKALVHFTVGPDVSLEEITKAMEIVYERLGEKSEIKWGAMIEEDMGKTVRAMVIMTGVRSPQILGNINVNALTYSSSSLVVPRDSKIMSESKVDEIFSSIDPRASKLRKGNNSSRINKIFKDLGFYEL
What is the function of this protein?
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.  The regulation of the ring assembly controls the timing and the location of cell division.  One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells.  Binds GTP and shows GTPase activity.
What are the official names of this protein?
Cell division protein FtsZ 2.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Protein: GPMA_ECOSM
Sequence: MAVTKLVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGYSFDFAYTSVLKRAIHTLWNVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPELTKDDERYPGHDPRYAKLSEKELPLTESLALTIDRVIPYWNETILPRMKSGERVIIAAHGNSLRALVKYLDNMSEEEILELNIPTGVPLVYEFDENFKPLKRYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: RL36_CUPNH
Sequence: MKVLASVKRICRNCKIIKRNGVVRVICSSDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: UPPP_FLAJ1
Sequence: MNTLQAIVLAVIEGITEFLPVSSTGHMIIASSFFGIAHEDFTKLFTIVIQLGAILSVVVLYFKRFFQTLDFYFKLLVAFIPAVVLGLLLSDFIDGLLENPVTVAVSLLIGGLILLKVDEWFNNPNAAETSQKITYLQALKIGLFQCIAMIPGVSRSGASIVGGMSQKLSRTTAAEFSFFLAVPTMLGATVKKCYDYYKAGFELSHDQVNILIIGNVVAFIVALLAIKTFISFLTKNGFKVFGYYRIIAGIILLLIHFFIHPLTII
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin (By similarity).
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PRTY2_CLUPA
Sequence: PRRRTRRASRPVRRRRPRRVSRRRRARRRR
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine-YII, Clupeine-YII.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: NADA_SULTO
Sequence: MELIKEIKNLKRNKNAIILGHNYMEYGVQLVSDFTGDSYDLAVKAMKTNADIIVFAGVYFMAEQAAALNPDKKVLSPDPNAGCSLSDSLDVDTLKKYKEMYPNAPVVLYINTSIYTKALADYIVTSSTAIKVVKSLDADTIIFGPDANLANYVERKTGKRLVKVPPNGRCIVHANYTRQLVELARKKYPNAILMAHPESPLEILEASDFVGSTNQMIKFAKESPYKEFIVATELGMINALKLQVPEKTFYPLVTTEAYACARCPYMAMITLEKIKRSLEEEIYEVKVPKDIAERAKEAFERTMRLLNN
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_PSEPK
Sequence: MAMTDSNPTRCGYVAIVGRPNVGKSTLLNHILGQKLAITSRKPQTTRHNMLGIKTEGDVQAIYVDTPGMHKANDKALNRYMNRNASAALKDVDVVIFVVDRTKWTDEDQLVLERVQYVTGPLIIAVNKTDRMEEKAELIPHLQWLQEQLPNAEVMPISAQQGHNLDALEAQIAKHLPENDHFFPEDQITDRSSRFLAAELVREKIMRQLGAELPYQITVEIEEFKQQGHVLHIHALILVERDGQKKIIIGDKGERIKRIGSEARKDMEVLFDSKVMLNLWVKVKGGWSDDERALRSLGYGDL
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: RL36_AZOC5
Sequence: MKIRNSLKSLLGRHRDNRLVRRKGRIYIINKTQKRYKARQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: RS5_STACT
Sequence: MARRDEEAKEFEERVVTINRVAKVVKGGRRFRFTALVVVGDKKGRVGFGTGKAQEVPEAIKKAVEAAKKDLVTVNRVEGTTPHTITGRFGSGSVLLKPAAPGTGVIAGGPVRAVLELAGITDILSKSLGSNTPINMVRATLNGLENLKNAEEVAKLRGKSVEELYN
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RNY_DEHMB
Sequence: MFEFFMETAPATTTGLPLSAILAIFFSFIIGIVFGGMALFVFRGFIMNRQLRIAQRKATKMLADSKLEAKDVLVEAKREADKTRNSAETELKERRSELAKQENRVIQKTEALDRKLENLEQREQSLTNREKSIDETQSQIEEIRENELKRLEEVANMTTEQAKTSLLEMLEGEMQQETSRRLREWEIKIKAEADEKAREVVSQAIQRCASDVVTETTTNVVPLPSDEMKGRLIGREGRNIRALEQATGVDLIIDDTPEAVTISSFDPVRREVARQALSKLIIDGRIHPARIEEVVTKAKEEVEAAMIASGEQAAYQAGVHGLRPEIIKVMGRLKYRTSYGQNVLQHSIEVAQMSGMIGSELGVNVTLARRAGFLHDIGKAVDRDVEGTHTQIGADMVKQWEKSPEVIKGVAEHHFDTPTVSIWGFIVSAADAISSARPGARRESLENYIKRLKALEEIADSFKGVEKSFAIQAGREVRIMVKPDEIDDLGAMRLARDIVKRIEDGLEYPGQIKVTVIRETRSVDFAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MNMC_HAEDU
Sequence: MHKLTFAQLSFNSDNTPVSEQFDDIYFSTEDGVQESYYVFQDGNQLWQKWQNHHRSAFVIAETGFGTGLNFLAVAEKFQQFRSTFPDSPLKRLYFISFEKYPLTQQQLADIHQHYPQFTQLSATLIACWQPRQAGCQRYHFDDVYLDIWFGEMLENLPQLGDLYNATVDSWFLDGFSPDKNPTMWHEQLYQHMFRLTRVGGSFATFTAASHVRCGLQAVGFTVYKRKGFAKKREMLCGEKAQKSQTAEVNFPYFYSPPAIVNDDIAIVGGGIASLFVALSLLERGKQVTLYCQDSQVAQKASGNAQGAIYPQLSDDDPRNVRFYVHCFDYALQRLKQFEKLVPFEHALTGVVLSAYNEKTAQKLQKIARQTQNQDLFKWCQAEELTEYLGVAIANEGAFIPQAGWLSPVQFVQQAFAYLQTKGLKIVLNHTVTDPQFVEGKWQWQYQGVQFAHHILVLANGHSFTQFSQAEGIPLYPVRGQVSQIPTTPALQKLKCVICYDGYLTPMATNGYHCIGASHVRDNTDMAFSAIEHQQNLAKLQQNIGAYHWTQGIDLSANLAKQGIRSALRDRVPMVGPIPHFAVQKQQYSNIYNLLRRKKAVENAVNFPHLYMVNGLASRGLTTAPLLGEMLASLIVNEPIPISQDIWHALLPNRTWLRKWLKGSKVV
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GH33_ORYSJ
Sequence: MLEKKATRSTRVDGVSGEAVIEEFERVTRDAANVQRETLRRILAENGGVEYLRGLGLAGATDPATFRARVPLATHADLEPYIDRIADGDASPVLTAKPATSISLSSGTTQGKRKYLLFNEELVKSTMQIYRISYAFRNREFPVENGKALQFIYSSRETRTKGGLTATTATTNVYRSEEFKATMRDIQSQCCSPDEVIFGPDFAQSLYCHLLAGLLAAGDVQIVSATFAHSVVLAFQTFERAWEDLCADIRRGEVSPSRVTSPAVRRAMAALLAAPNPGLADEVARKCAALSNWYGVIPALWPNARYVYGIMTGSMEHYVKKLRHYAGGLPLVAAEYGASEGWVGANVEPGTPPERATFTVLPDIAYFEFIPLKPVAGDGGYAEAEPVGLTEVAAGELYEVVMTTFAGNTRSSSSCMTLVAYYYLQSKKWMNICRFCISVHETSRNLVTCTFAATGHIMFAQK
What is the function of this protein?
Catalyzes the synthesis of jasmonate-amino acid conjugates by adenylation.  Catalyzes the conjugation of jasmonate (JA) to Ile when expressed in a heterologous system (E. Coli) (PubMed:21619871).  Catalyzes in vitro the conjugation of jasmonate (JA) to Ile, Phe, Leu, Met, Val and Trp (PubMed:24033451).  May catalyze the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin (By similarity).
What are the official names of this protein?
Jasmonoyl--L-amino acid synthetase GH3.3, Auxin-responsive GH3-like protein 3, OsGH3-3, Indole-3-acetic acid-amido synthetase GH3.3, Jasmonate-amino acid synthetase JAR2, Jasmonic acid-amido synthetase JAR2, Protein JASMONATE RESISTANT 2, OsJAR2.
What is the protein family that this protein belongs to?
Belongs to the IAA-amido conjugating enzyme family.
Protein: VINSY_RAUSE
Sequence: MAPQMEKVSEELILPSSPTPQSLKCYKISHLDQLLLTCHIPFILFYPNPLDSNLDPAQTSQHLKQSLSKVLTHFYPLAGRINVNSSVDCNDSGVPFVEARVQAQLSQAIQNVVELEKLDQYLPSAAYPGGKIEVNEDVPLAVKISFFECGGTAIGVNLSHKIADVLSLATFLNAWTATCRGETEIVLPNFDLAARHFPPVDNTPSPELVPDENVVMKRFVFDKEKIGALRAQASSASEEKNFSRVQLVVAYIWKHVIDVTRAKYGAKNKFVVVQAVNLRSRMNPPLPHYAMGNIATLLFAAVDAEWDKDFPDLIGPLRTSLEKTEDDHNHELLKGMTCLYELEPQELLSFTSWCRLGFYDLDFGWGKPLSACTTTFPKRNAALLMDTRSGDGVEAWLPMAEDEMAMLPVELLSLVDSDFSK
What is the function of this protein?
Acetyltransferase that catalyzes the formation of vinorine, a precursor of the antiarrhythmic monoterpenoid indole alkaloid ajmaline.  Acts on gardneral, but not on polyneuridine aldehyde or N-methylgardneral.
What are the official names of this protein?
Vinorine synthase.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: RR11_CYACA
Sequence: MLKQSKKSSKKLKKSVIDGLIIINSTFNNTIVTATDCYGKVIAWASGGTEGFKGAKKGTPFAAQSATEKLIKALLEQGTQRIHISVSGPGPGRETSIRSFQTSGLQIISIKDITSVPFNGCRPPKKRRI
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DNLJ_MARMM
Sequence: MSALKDVDQLTEAEARAEHARLAREIAGHDKAYYQSDAPKISDAAYDALRRKLEAIEVRFPQFIDLLSPTQRVGAVPSGKFGEIRHAVPMLSLGNAFNDEDVADFVGRIRRFLGLAESDVVAVTAEPKIDGLSASLRYVGGKLVHGATRGDGQTGEDVTQNLLTLDDIPDTLPPGDWPDVVEVRGEVYMSHADFAALNERQIEAGKDAYKNPRNAAAGSLRQIDPKMTSQRPLRFFAYAWGEVSEPLSDTQMGAVARFGEMGFPVNDLMARCETVEALLAVYRDIEARRAGLGYDIDGVVYKADRLDWQERLGFVARAPRWAIAHKFPAEQATTILEAIDIQVGRTGALTPVARLTPVTVGGVVVTNATLHNQDEIERKDIRVGDTVVIQRAGDVIPQVVRVVDPDRPGRGEAFDFPTECPVCGSQALREHDAKTGKLDVVRRCTGGLICGAQLKERLKHFVSRKAFDIEGLGIKQIEAFQEEGLITEPAHIFTLKARNEAGEIKPPLQEREGFGETSIRNLFTSIEDRRTITLARFLNALGIRHVGENTSALFARTYGSWAAFHAAAANLSDEAVRAEMLGIDGIGNAAVEALEQYFTEAHNRDLLDRLVAQLTIEDAEAIANDSPVAGKTVVFTGALERMTRDEAKAKAQALGAKVAGSVSGKTDYLVAGPGAGSKAKKAAELGVETLTEDEWFDLIGA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RECR_PSEPK
Sequence: MSFSPLIRQLIDGLRILPGVGQKTAQRMALQLLERDRSGGLRLAQALTQAMEGVGHCRQCRTLTEQELCPQCADPRRDDTQLCVVEGPTDVYAVEQTGYRGRYFVLKGHLSPLDGLGPEAIGIPQLMARIEEQGTFTEVILATNPTVEGEATAHYIAQLLSEKGLVASRIAHGVPLGGELEMVDGGTLAHAFAGRRPISL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: LKA13_MANHA
Sequence: MGNKFTNISTNLRNSWLTAKSGLNNAGQSLAKAGQSLKTGAKKIILYIPKDYQYDTEKGNGLQDLVKAAQELGIEVQKEEGNDIAKAQTSLGTIQNVLGLTERGIVLSAPQLDKLLQKTKVGQAIGSAENLTKGFSNAKTVLSGIQSILGSVLAGMDLDEALQKNSNELTLAKAGLELTNSLIENIANSVKTLDAFGDQINQLGSKLQNVKGLSSLGDKLKGLSGFDKTSLGLDVVSGLLSGATAALVLADKNASTSRKVGAGFELANQVVGNITKAVSSYILAQRVAAGLSSTGPVAALIASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASVTAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEKNNGGKNYFENGYDARYLANLQDNMKFLLNLNKELQAERVIAITQQQWDSNIGDLAGISRLGEKVLSGKAYVDAFEEGQHLKADKLVQLDSAKGIIDVSNTGEAKTQHILFRTPLLTPGTEKRERVQTGKYEYITKLHINRVDSWQIKDGAASSTFDLTNVVQRIGVELDHAENVIKTKETKIVATLGDGDDNVFVGSGTTEIDGGEGYDRVHYSRGNYGALTIDATKETEQGSYTVNRFVESGKALHEVTSTHTALVGNREEKIEYRHSNNQHHAGYYTKDTLKAVEEIIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDIIDGGNGDDFIDGGKGNDLLHGGKGDDIFVHRQGDGNDSITESEGNDKLSFSDSNLKDLTFEKVNHHLVITNTKQEKVTIQNWFREAEFAKTIQNYVATRDDKIEEIIGQNGERITSKQVDELIEKGNGKIAQSELTKVVDNYQLLKYSRDASNSLDKLISSASAFTSSNDSRNVLASPTSMLDPSLSSIQFARAA
What is the function of this protein?
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture.  The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell (By similarity).  This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis.  It has also weak hemolytic activity.
What are the official names of this protein?
Leukotoxin, Lkt.
What is the protein family that this protein belongs to?
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein.
Protein: ACYP_COREF
Sequence: MSMQPTDHIRLTAFVHGHVQGVGFRWWTRSQALELGLAGSATNLDDGRVCVVAEGPEDRCRELLTRLGEQPSRHRRVGTVSTVIEQWSEPRGVEGFTER
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: ATPA_GEOSM
Sequence: MEIKAEEISEIIRKQIKEYGTEVAVAETGTIISIGDGIARIHGLDKAMAGELLEFPGGITGMVLNLEEDNVGAAILGEFSEIKEGDSVKLTGKIVEVPVGPALIGRVVDAIGNPIDGLGPINTDTFGKVEVKAPGIVKRKSVHQPMQTGLKAIDSMVPIGRGQRELIIGDRQTGKTAVAIDTIINQKGGDVVCIYVAIGQKRSTVAQVVSKLKEHGAMDYTIVVAATASEPAPLQFIAPYTGVTMGEFFRDSGKHALIIYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERACKVSDDCGAGSLTALPVIETQAGDVSAYIPTNVISITDGQIYLESDLFYSGVRPAINVGLSVSRVGGSAQVKAMKQVAGTLRLALAQYREMAAFAQFGSDLDKATQMQLARGARLVEILKQPQYRPIPNEKQVLIIFAANNGFVDEYPIGSLGRYETELYAFFDSRKATLLGELRDKKAIDDAMKGEIIASLEEFKKEFTA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DNAJ_BRUMB
Sequence: MKIDYYEALGVTRTADDKTLKAAFRKLAMQYHPDRNPDDPEAERKFKEIGEAYETLKDPQKRAAYDRFGHAAFENGGMGGGFGNGFGGAGGFADIFEDIFGEMMGGGRRRSNGGRERGADLRYNMEVTLEEAYAGKTAQIRVPTSITCDECSGSGAKPGSQPTTCTMCSGSGRVRAAQGFFSVERTCPGCNGRGQIIKDPCEKCHGQGRVTQERSLSVNIPAGIEDGTRIRLAGEGEAGLRGGPAGDLYIFLSVKPHEFFQRDGADLYCKVPISMTTAALGGQFEVSTLDGTQTRVKVPEGTQNGKQFRLKGKGMPVLRQSVTGDLYIQIDIETPQNLSKRQRELLEEFEKLSSQENSPKSAGFFSRMKEFFEGIGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLTC_ECOK1
Sequence: MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIAGPKDYVKYTDQYQTRSHINFDDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLKNRLKSRSNGLRIIYSVTINMVPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: ATP6_MYCTO
Sequence: MTETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAFYLRAKVTSTDVPGGVQLFFEAITIQMRNQVESAIGMRIAPFVLPLAVTIFVFILISNWLAVLPVQYTDKHGHTTELLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKLLKGHVTLLAPINLVEEVAKPISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLFVGAIQAFIFALLTILYFSQAMELEEEHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SCOT1_MOUSE
Sequence: MAALKLLSSGLRLGASARSSRGALHKGCVCYFSVSTRHHTKFYTDPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLLLRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYEKRIERLSLRKEGDGKGKSGKPGGDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGGHVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIKKSTGCDFAVSPNLMPMQQIST
What is the function of this protein?
Key enzyme for ketone body catabolism.  Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA.  Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (By similarity).  Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor (3-oxo acid) carboxylate and produce a new acyl-CoA.  Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).
What are the official names of this protein?
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial, SCOT, 3-oxoacid CoA-transferase 1, Somatic-type succinyl-CoA:3-oxoacid CoA-transferase, SCOT-s, Succinyl-CoA:3-oxoacid CoA transferase.
What is the protein family that this protein belongs to?
Belongs to the 3-oxoacid CoA-transferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CLC4M_SYMSY
Sequence: MSDSKEPRVQPLGLLEEDPTTSGIRLFPRDFQFQQTHGHKSSTGCLGHGPLVLQLLSFALLAGVLVAILVQVYKVPSSLSQEQSEQDVIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKQQEIYQELTQLKASVGELPEKSQLQEIYQELTRLKAAVGELPEESRLQEIYQELTRLKAAVGELPEKSRLQEIYQELTRLKAAVGELPEKSRLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPDQSKQQQIYQELTDLKTAFERLCCRCPKDWTFFQGNCYFMSNSQRNWHDSVTACQEVGAQLVVIKSAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSSSFQRYWNSGEPNNSGDEDCAEFSGSGWNDNRCNVDNYWICKKPIACFRDE
What is the function of this protein?
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver.  May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments.  Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.  Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity).
What are the official names of this protein?
C-type lectin domain family 4 member M, CD209 antigen-like protein 1.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: CTU2_DROPE
Sequence: MCSIGEDDVGDEGATHAMVAESLPTGIVISPGDCNKCGVVSSELYKLNFRVAECRDCFLNHARHKFRASLGAAKVLPRNAEVLLAVDGSAESLVLLDMLHFAQTQNTFRRLHCNARVVYIDDQSVHGGESMNLQALQALGTRYEPLEFYVVELGASACSLQRLGQYSTSLKEPNGLNTKLEKLRSLTARQDYHQQQRKNLLASVAQKLSCSHVFEPSVSGDLATQLLTSIALGRGGSAALDVALLDDRLAAGVKLLRPLRDLNEQEVRFYVHACQLKPLRESGSSYGQERGQTASLQNLTAAFVGNLQQNYPATVSTVFRTGDKIAANAHMEQASCAQCQSPLDAKLSDTLLAIEYSRAVSEAGVGLSKDGDASESLAKQRLEFKDGLCHACRCIQLELGYDTLS
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 2.
What is the protein family that this protein belongs to?
Belongs to the CTU2/NCS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_THEKO
Sequence: MGDPKRQRKKYETPSHPWIKERLDRERVLKRNYALKNKKELWRHETQLKEFRRRARRLLAARGKQAEIERQQLLQRLYRLGLLPADAVLDDVLSLTVEDVLERRLQTIVYRKGLARTMKQARQLIVHGHIEVNGQVIRSPGYLVLREEEDTITYAKGSPFAKEGHPERMVIEQAKQGGEA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.