PharMolix/UniProtQA huggingface dataset:
Protein: MOAC_BORPD
Sequence: MSSPSPALSHLDESGQIRMVDVGAKSASDRIAIARGAVRMNALAYGLLTQPGQGKGEVLNTARVAAVLAAKRCAELIPLCHSLPLAFVGVDFSLDDATHTVEVRATCRTHYKTGVEMEAMTAASVAALTIYDMCKAADKGIVIEQIRLEYKAGGKSGEWRND
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: GPMA_BRUAB
Sequence: MSRTLVLVRHGQSEWNLKNLFTGWRDPGLTEQGHAEAKAAGQRLKAAGLKFDIAYTSALSRAQVTCQHILDELGQPGLETIRDQALNERDYGDLSGLNKDDARAKWGEEQVHIWRRSYDVPPPGGESLKDTGARVWPYYLHTIQPHVLREETVLVAAHGNSLRALIMALDGLTPEQILKQELNTGVPIIYRLNADSTVASKEILSA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: MURB_ANADE
Sequence: MTWRDEIARRVRGEHLRDAPLAPRTAVRVGGPADLLCRPADGDALSALLGAVRELGVPLSVLGGGANTLVADAGVRGVVLRLPQDFPGESTDGDTLVLSAGAPIARLPARAHAHGLVGMEFLGGIPGTLGGAAAMNAGTRLGEMKDVVTRLELATADGAGFVPAAALGYAYRTCRLPPGAVVARVEVRLRPGDVAASEALMREDRERRRATQPLDRPTFGSTFTNPPGEYAGRLIEAVGLKGHRVGGAVWSPVHANFVTNLGGATARDVLALIRLARARVKERFGIALETEVRLMGEFPPDELAGLDGHAADGGGPGAASGGARPREAT
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EAMB_SHIBS
Sequence: MTPTLLSAFWTYTLITAMTPRPNNILALSSATSHGFRQSTRVLAGMSLGFLIVMLLCAGISFSLAVIDPAAVHLLSWAGAAYIVWLAWKIATSPTKEDGLQAKPISFWASFALQFVNVKIILYGVTALSTFVLPQTQALSWVVGVSVLLAMIGTFGNVCWALAGHLFQRLFRQYGRQLNIVLALLLVYCAVRIFY
What is the function of this protein?
Exporter of O-acetylserine (OAS) and cysteine.
What are the official names of this protein?
Cysteine/O-acetylserine efflux protein.
What is the protein family that this protein belongs to?
Belongs to the Rht family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AAAD_BOVIN
Sequence: MRKKYFGFLILGVLLAGYIYVPLPDNVEEPWKIMLLNTFLKTSSYLALFGEILGLNHFMKSMALFSRIQGFPPTSDENIIVKDTTFNDIPVRIYVPQQKTKSLRRGLFYIHGGGWCFGSNDYYSYDLLSRWTAERLDAVVISTNYRLAPKYHFPVQFEDVYTALKWFLDPQNLESYGVDPGRIGISGDSAGGNLAAAVAQQLLEDPDVKIKLKVQTLIYPALQNFDFDLPSYRENAHYPVLSKSLMVRFWSEYFTTDRSLKKAMLSNQHIPLESSNLFKFVNWSSLLPEKFKKGHIYKTPTHGSSELAKKYPGILDVKASPLLADDSKLRGLPLTYVITCQYDVLRDDGLMYVTRLQKSGVQVIHNHVEGAFHGTLAFLFTKVGYRAANQYINWLHENL
What is the function of this protein?
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly.  Displays serine esterase activity in liver.  Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity (By similarity).
What are the official names of this protein?
Arylacetamide deacetylase.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
Protein: DUT_AQUAE
Sequence: MSKVILKIKRLPHAQDLPLPSYATPHSSGLDLRAAIEKPLKIKPFERVLIPTGLILEIPEGYEGQVRPRSGLAWKKGLTVLNAPGTIDADYRGEVKVILVNLGNEEVVIERGERIAQLVIAPVQRVEVVEVEEVSQTQRGEGGFGSTGTK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: LDH_BORT9
Sequence: MLKRNKVVLVGAGGVGSSFAYALTIDNSLVHELIIIDLAQDKAKGEVMDLNHGQMFLEKNIKIEFGNYDDCSDADIVVITAGLNQKPGETRLDLVGKNTKIFKEIVTSVVSSGFSGIFVIASNPVDIMTYVTMKYSNFPTHKVIGTGTTLDTSRLRYFLAERFNVNTQNIHSYIMGEHGDSSFATWDETKIAMKSLSEYLAEGKVSDAELDEMHKNVVNAAYEVIKLKGATYYAIGLGIKKIVNAIISDQNLILPISSYINGQYGNFVKDIYIGAPSVVCKDGIKEVLDFTISDRELEKFKISASQLKSYIDKIEF
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y466_TREPA
Sequence: MSSKHKRRILNLPLKLVLTQEGSEFFIKQNRKLMKLKLAEHVEDYGIALDAFAPKTVQGLLLSGYVSLIEVSPPEFASSRQEIIDLSKLIVHSILYRQYDCYVFRQILNSEVIKKWNRSNPGSSIDEHANLNAPFIYNHLKQHEAHVTQIKHHILRLLHASLAACEERTPKEKNTLLFLGEKFLDTLRPFTWFIISKFQHAPDMGSVLSSIHTSLAQYLNKARIAEYIALVLVELLINEENTNLKKEVQKLFPDLEDAQEALCDEGIRRRIVAELKHNAESLFISWKLQGRSVSTAGTRRKLKITVYGRNDYPQEMRNCLQDAKVVNADTDTLVDYCQQTIDTAKHANLGVYYISYLSEACKEANVRFESSLNRFTRSEFTTVDLSFEF
What are the official names of this protein?
Uncharacterized protein TP_0466.
Protein: PUR7_SHEFN
Sequence: MSLADSVLAVNNDLPIRTDKPVHSGKVRSVYWLTDTDSRRLIRDKGYDVPEDTPLAIMVISDRISAFDCIFHGEGDLQGIPGKGAALNAISNHWFGLFAENGLADSHILDIPHPFVWIVQKARPIKVEAICRQYITGSMWRAYSKGERVFCGITLPEGLSKDQKLPELLITPSTKGILTGIPGVPAQDDVNISRSDIEANYQAFGFEKPQDIDLYETLLKQGFKVISDALAKLDQVFVDTKFEFGYVNDKNGQSKLIYMDEVGTPDSSRIWDGAAYREGKIVENSKEGFRQFLLNHFDDADILLNKDRMPEREALARDNDLPLDAMMNVSRTYIGVAEKVTGSSIPLPANPKADIIKVLREQYDLIV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: ILVC_ASPFU
Sequence: MLLSQTRGRLPSTLRSFSRRALSTTLPRGKDSEETALNKVSRNVTQPISQGASQAMLYATGLTEEDMNKAQVGISSVWYNGNPCNMHLLDLSNRVREGVQKAGLVGFQFNTVGVSDAISMGTKGMRYSLQSRDLIADSIETVMGGQWYDANISIPGCDKNMPGVLMAMGRVNRPSLMVYGGTIKPGCARTQNNADIDIVSAFQAYGQFLTGEITENQRFDIIRNACPGGGACGGMYTANTMATAIEVMGMTLPGSSSNPAESKAKDLECLAAGEAIKRLLKEDIRPSDILTRQAFENAMIVVNITGGSTNAVLHLIAIADSVGIKLDIEDFQKVSDRTPFLADLKPSGKYVMADLHNIGGTPSLLKFLLKEGVIDGSGMTVTGETLAKNLEKVPDFPADQKIIRPLSNPIKKTGHIQILRGSLAPGGSVGKITGKEGTRFVGKARVFDDEDDFIAALERNEIKKEEKTVVVIRYTGPKGGPGMPEMLKPSSALMGAGLGSSCALITDGRFSGGSHGFLIGHIVPEAAVGGPIGLVKDGDTITIDAEKRLLDLDVDETELARRRKEWEALRDAGKLPQTGLTMRGTLGKYARTVKDASHGCITDSVE
What is the function of this protein?
Dihydroxyacid dehydratase that catalyzes the third step in the common pathway leading to biosynthesis of branched-chain amino acids (PubMed:23028460).  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively (By similarity).  IlvC and the branched-chain amino acid biosynthesis are crucial for virulence and may be a potential target to develop antifungal agents (PubMed:23028460).
What are the official names of this protein?
Dihydroxy-acid dehydratase ilvC, mitochondrial, DHAD ilvC.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UBP13_BOVIN
Sequence: MQRRGALFGMPGGSGSRKMAAGDIGELLVPHMPTIRVPRSGDRVYKNECAFSYDSPNSEGGLYVCMNTFLAFGREHVERHFRKTGQSVYMHLKRHVREKVRGASGGALPKRRNSKMFLDLDTDDDLNSDDYEYEDEAKLVIFPDHYEIALPNIEELPALVTIACDAVLSSKSPYRKQDPDTWENELPVSKYANNLTQLDNGVRIPPSGWKCARCDLRENLWLNLTDGSVLCGKWFFDSSGGNGHALEHYRDTGYPLAVKLGTITPDGADVYSFQEEEAVLDPHLAKHLAHFGIDMLHMHGTENGLQDNDIKPRVSEWEVIQETGTKLKPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELIAYELTRREAESNRRPLPELVRAKIPFSACLQAFSEPENVDDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFDVSVDMPDLLDINHLRARGLQPGEEELPDISPPIVIPDDSKDRLMTQLIDPSDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWIVVHMEEPDFAEPLTMPGYGGAASAGASVFGATGLDNQPPEETVAIITSMGFHRNQAIQALRATNSNLERALDWIFSHPEFEEDSDFVIEMENNANANIVSEAKPEGPRVKDGSGMYELFAFISHMGTSTMSGHYVCHIKKEGRWVIYNDHKVCASERPPKDLGYMYFYRRIPS
What is the function of this protein?
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).  Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes.  Also deubiquitinates USP10, an essential regulator of p53/TP53 stability.  In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13.  Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD).  Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex.  Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination.  Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains.  In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly.  Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 13, Deubiquitinating enzyme 13, Ubiquitin thioesterase 13, Ubiquitin-specific-processing protease 13.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: RHAD_YERP3
Sequence: MQAILSSWFIQGMIKATSDMWHKGWDERNGGNISLRLLAEEVEPYRRDFYQQPRKVELTQPAPELANSWFLVTGSGKFFRNVELNPAENLVLLQVSNDGMAYDIHWGLTQGGLPTSELAAHFQSHIVRMQVSGGTNRVIMHCHATNLIALSYVQKLENASFTRLLWEGSTECLVVFPDGIGIVPWMVPGTDGIGTQTAEQMREHSLVLWPFHGIFGSGPTLDDAFGLIDTAEKSAEIMVKVLSMGGKKQTISREQLIALAARFDVTPMAAALDA
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_STAAM
Sequence: MSSIVVVGTQWGDEGKGKITDFLAEQSDVIARFSGGNNAGHTIQFGGETYKLHLVPSGIFYKDKLAVIGNGVVVDPVALLKELDGLNERGIPTSNLRISNRAQVILPYHLAQDEYEERLRGDNKIGTTKKGIGPAYVDKVQRIGIRMADLLEKETFERLLKSNIEYKQAYFKGMFNETCPSFDDIFEEYYAAGQRLKEFVTDTSKILDDAFVADEKVLFEGAQGVMLDIDHGTYPFVTSSNPIAGNVTVGTGVGPTFVSKVIGVCKAYTSRVGDGPFPTELFDEDGHHIREVGREYGTTTGRPRRVGWFDSVVLRHSRRVSGITDLSINSIDVLTGLDTVKICTAYELDGKEITEYPANLDQLKRCKPIFEELPGWTEDVTSVRTLEELPENARKYLERISELCNVQISIFSVGPDREQTNLLKELW
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTRB_ARCFU
Sequence: MLISKTLIFYQVVNIVSQKGSGKRRWKMENGDRYVYVVDVSKCYGCLSCVAACAAENNVPVGYFRTWVERYAMNGRVAFVPKICNHCDNPSCVHACPVNATYKTEEGLVLIDDEICIGCGACIQACPYGARFRNPVKGTADKCTLCNHRIPERLPACVESCPTSARVYGKMSDKAVKEILSKKNAVVLKAYTGNEPHTYYVSLTGVE
What is the function of this protein?
Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate.  TtrB is probably involved in transfer of electrons from TtrC to TtrA (By similarity).
What are the official names of this protein?
Tetrathionate reductase subunit B, Tetrathionate reductase electron transport protein.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FOLD_CHLFF
Sequence: MLLKGTPVAERILEKLKQKISQSPTPPGLAVVLIGNDPASEVYVGMKVKKAMNLGMVSKAHRLPSDATLTDILKLIERLNNDPTIHGILVQIPLPKHLDSNVIIQAISPEKDVDGLHPVNMGKLLLGQLGGFSPCTPAAVIELLNYYDIPLQGRHVAVVGRSNIVGKPLAAMLMQKHPTTNATVTLLHSQSQNFTEILKTADIIVAAVGVPLFIQENMISPNAVIVDVGISRVATNNDKGYMLVGDVDFNNVVTKCKAITPVPGGVGPMTVAMLMKNTWESYQKSSS
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: Y207_MYCGE
Sequence: MIKVLVIADTHGQNQRWIELKNYHNPDVIIHAGDHMTTKQFMDQNATFWVAGNNDSIGNEIEIFQLGQINFVLMHGHQAPRDNLKKWYQLLVLKAQQYPCDVLIFGHSHIEYTNKINMIQLINPGSLQLPRNQTNTPSYCTFIVNKDELTDLTIHYYQASKVS
What are the official names of this protein?
Putative metallophosphoesterase MG207.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. YfcE family.
Protein: THF1_PROM1
Sequence: MSVRATISDSKSDFHKEFPYVIPAIYRKLADELLVELHLLSHQKNFKKDSIFSTGLKEVFCKFTSGYKPSEHVTKLFDAICNCNGFNPTEINNSSEQLVSNAKSFTKEDLNSFLSKTNNDNKGYDYYSRINAIGIYKLVSEMPLFKEVKEEDLNKEINDISKSLGYQYSRVEKDISMYKSNIEKMKQALEIIALNLKTK
What is the function of this protein?
May be involved in photosynthetic membrane biogenesis.
What are the official names of this protein?
Protein Thf1.
What is the protein family that this protein belongs to?
Belongs to the THF1 family.
Protein: POI_MUSDO
Sequence: AVTDNEIVPQCLANGSKCYSHDVCCTKRCHNYAKKCVT
What is the function of this protein?
Potent reversible, competitive inhibitor of tyrosinase (phenol oxidase) in the nanomolar range.
What are the official names of this protein?
Tyrosinase inhibitor, Phenol oxidase inhibitor, Phenoloxidase inhibitor, POI.
What are the subcellular locations of this protein?
Secreted.
Protein: TELL_STAAW
Sequence: MTENKSFKESHPLDDFISDKELSNTTIQKEKLTIEQQKQVDTISKQINPLDNEGLLAFGSDLQKQMSQFSHQMLDEVQSKDVGPIGDTLSDLISKLKSVNPNELNTDKPSMLKRIFSRAKSSINEIFSRMQSVSAQVDRITIQLQKHQTHLTRDIELLDTLYDKNKQYFDDLSLHIIAAQQKKLQLENEKLPQLQQQAQQSTNQMDIQHVADMQQFIDRLDKRIYDLQLSRQIALQTAPQIRMIQNVNQALAEKIQSSILTSIPLWKNQMAIALTLMRQRNAVAAQRAVTDTTNDLLTANAEMLKQNAIETATENERGIVDLDTLKRTQRNIIETIEETLIIQQHGREERQLAEKELQQLEQDLKSHLVNIKGTNKQS
What are the official names of this protein?
TelA-like protein MW1294.
What is the protein family that this protein belongs to?
Belongs to the TelA family.
Protein: CBPM_ECOLU
Sequence: MANVTVTFTITEFCLHTGISEEELNEIVGLGVVEPREIQETTWVFDDHAAIVVQRAVRLRHELALDWPGIAVALTLMDDIAHLKQENRLLRQRLSRFVAHP
What is the function of this protein?
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA.  Together with CbpA, modulates the activity of the DnaK chaperone system.  Does not inhibit the co-chaperone activity of DnaJ.
What are the official names of this protein?
Chaperone modulatory protein CbpM.
What is the protein family that this protein belongs to?
Belongs to the CbpM family.
Protein: MNTP_FUSNN
Sequence: MSTISVLITALALSMDAMSLSIYQGIASTESQKKQNFLKIVLTFGIFQFAMALVGSLSGILFIHYISLYSKYVSFAIFLFLGLMMLKEALKKEEMEYDEKYLDFKTLIIMGIATSLDALLVGLTFSILPFYQTFLYTVEIGVITAIIAGLGFILGDKFGNILGQKSHFLGAALLIFISINILL
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS182_STRGG
Sequence: MAKPPVRKPKKKVCAFCKDKTQYVDYKDTNMLRKFISDRGKIRARRVTGNCTQHQRDVATAVKNSREMALLPYTSTAR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: ANGI_PIG
Sequence: KDEDRYTHFLTQHYDAKPKGRDGRYCESIMKQRGLTRPCKEVNTFIHGTRNDIKAICNDKNGEPYNNFRRSKSPFQITTCKHKGGSNRPPCGYRATAGFRTIAVACENGLPVHFDESFIITSQ
What is the function of this protein?
Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity).  Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus (By similarity).  Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA (By similarity).  Angiogenin induces vascularization of normal and malignant tissues (PubMed:8448182).  Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity).
What are the official names of this protein?
Angiogenin, Ribonuclease 5, RNase 5.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).
Protein: PYRD_STRAW
Sequence: MYKLFFRLVFKRMDPEQAHYLAFRWIRLAARIPVLRTFVAAALAPRFKELRTEAFGLRMHGPFGLAAGFDKNAVAVDGMSMLGFDHVEIGTVTGEPQPGNPKKRLFRLVPDRALINRMGFNNEGSAAVAARLAAREAVFRTVVGVNIGKTKVVPEEEAADDYVKSTERLARHADYLVVNVSSPNTPGLRNLQATEALRPLLSAVREAADRTVTERRVPLLVKIAPDLADDDIDAVADLAVELGLDGIIATNTTIAREGLGLKSEPTLVKETGGLSGAPLKARSLEVLSRLYARVGDRITLVGVGGIENAEDAWQRILAGATLVQGYSAFIYEGPFWGRAIHKGLAARLRTSPYATLADAVGADVRKSA
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: VND_DROME
Sequence: MTTSASLERTPSKRDRDRERDNSSGLGSAGSLPASPQSAITVSPSSPATPKRPLRTSTPSLERKREREDREDREDRKERQERHERDRDHERFAAVFSTASTTVPTNTSSSSGLAPEQLRIPTGAAAFSGFPGLHSMSSLMLPSSAAVAAAAAAPFLPWSPILLPPWNHALLPAAFYPAALRNALPGLFDAKVPSSQRSGFHISDILNLEGSELKNAAAAAAAAAHHGSDLSHHSASESTSGHRGQGSHTSPSALSPTPAGVSADEHHNGSGTGGGAGEADHHSTTEHHAPPSHPQQQHPHHQQHHHPHLLLPQQHHQQAVAPLPLAHHQSGEAQSHAHANAAAAHLLASHNAAAAAAVAAGQYLPNLPKNFPGSFGDEMSSYHHMAQTMLQHSGRSAWIKENELYGTQQPASPDSTSPVTSEVSYTYIGSNCQTSPALSGDYKSYSRSADSDALSVGDALHTLHGSSGNGSAGGAPTAHALHNNNNNTTNNNNHSLKAEGINGAGSGHDDSLNEDGIEEDIDDVDDADGSGGGDANGSDGLPNKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKRAQNEKGYEGHPGLLHGHATHPHHPSALPSPRRVAVPVLVRNGKPCLGDSSKLGADCVSVSSATATAMQNAAAHHLVALNGAAAYQHAAAAAAGLHAHAHAHAHAHGHGHPHAHAQRAAWWP
What is the function of this protein?
Probable transcriptional regulator involved in the regulation of the proneural AS-C genes and the neurogenic genes of the enhancer of split complex.  Could specifically activate proneural genes in the ventral-most neuroectoderm.
What are the official names of this protein?
Homeobox protein vnd, Homeobox protein NK-2, Protein ventral nervous system defective.
What is the protein family that this protein belongs to?
Belongs to the NK-2 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NTPPA_PARD8
Sequence: MLENLKKYKIVLASNSPRRRNLLSGLDIDFEVRVISDIDESYPDSIDSMEIPLYIARSKAEAYKPTMADDELLITADTIVWTFDGVMGKPANREEAYAMLHALSDHVHQVITGVCIMTKDKNVGFSVESAVCFAKLGDEEINYYLDKYKPYDKAGGYGIQEWIGYIGVEAINGSFYNVMGLPVQKLYQELKHF
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_YEAST
Sequence: MARRPARCYRYQKNKPYPKSRYNRAVPDSKIRIYDLGKKKATVDEFPLCVHLVSNELEQLSSEALEAARICANKYMTTVSGRDAFHLRVRVHPFHVLRINKMLSCAGADRLQQGMRGAWGKPHGLAARVDIGQIIFSVRTKDSNKDVVVEGLRRARYKFPGQQKIILSKKWGFTNLDRPEYLKKREAGEVKDDGAFVKFLSKKGSLENNIREFPEYFAAQA
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L10, L9, Large ribosomal subunit protein uL16, Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCDA_ARCFU
Sequence: MFSTSDGILTVEGVKVTEIVRETGTPVYVTSRALLERNLEAYKKAFSNEGLLYAVKANNNLALMRIIASHGFGADVFSDGELYLASLAGFRKDMVLFNGNSKSRKEIEMGVTAGVKFSVDSLDELRTISKIAKEVGKEVEIAFRVNPDVDPKTHPKIATGLRESKFGIPHEMVREAYEMALKLDGVVPVGIHCHIGSQILDLSPFVHALNKVMDIAVDIEKLGVELSFVDMGGGLGIDYEGKGAPTPKDLASAILPEFEGRKADLTSDPQLWLEPGRSIVGNTTVLITRVNAVKKGYKNFVAVDAGFNVLIRPAMYGSYHRVAVANKMDAEPEEVYTVVGPICESGDVLARDRKLPKVEVGDLIAVFDAGAYGFVMSSQYNGRPRCAEVLVSGDRWDVIREKESYGDLIEKQRLPEWLL
What is the function of this protein?
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
What are the official names of this protein?
Diaminopimelate decarboxylase, DAP decarboxylase, DAPDC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
Protein: RPOZ_EXIS2
Sequence: MLYPSVDKLQKTVPSKYTIVTVAAKRARQIQDGKRVKVANPKSYKPVGKALEELFSGEVVVTNQPQD
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.