PharMolix/UniProtQA huggingface dataset:
Protein: IL8_TURTR
Sequence: MTSKLAIALLAAFLLSAALCKAAVLSRMTSELRCQCINIHSTPFHPKFIRELRVIESGPHCENSEIIVKLVNGKEVCLNPKEKWVQKVVQIFLKRAEKKDP
What is the function of this protein?
Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection.  Also plays an important role in neutrophil activation.  Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells.  G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
What are the official names of this protein?
Interleukin-8, IL-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GPA1_ARATH
Sequence: MGLLCSRSRHHTEDTDENTQAAEIERRIEQEAKAEKHIRKLLLLGAGESGKSTIFKQIKLLFQTGFDEGELKSYVPVIHANVYQTIKLLHDGTKEFAQNETDSAKYMLSSESIAIGEKLSEIGGRLDYPRLTKDIAEGIETLWKDPAIQETCARGNELQVPDCTKYLMENLKRLSDINYIPTKEDVLYARVRTTGVVEIQFSPVGENKKSGEVYRLFDVGGQRNERRKWIHLFEGVTAVIFCAAISEYDQTLFEDEQKNRMMETKELFDWVLKQPCFEKTSFMLFLNKFDIFEKKVLDVPLNVCEWFRDYQPVSSGKQEIEHAYEFVKKKFEELYYQNTAPDRVDRVFKIYRTTALDQKLVKKTFKLVDETLRRRNLLEAGLL
What is the function of this protein?
Exhibits a fast rate of basal nucleotide exchange.  Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  Together with GCR1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate (IP(3)) as a second messenger.  Promotes abscisic acid (ABA) responses in guard cells.  Involved in the blue light (BL) signaling.  Together with GCR1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings.  Modulates root architecture (e. g.  lateral root formation).  Negatively regulated by RGS1.  In collaboration with CAND2/PMTR1, regulates the melatonin-mediated stomatal closure involving H(2)O(2) and Ca(2+) signals (PubMed:29702752).
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-1 subunit, GP-alpha-1.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RIMM_HYDCU
Sequence: MMSSKQDEKIILGQINGIYGVQGWVKIFSHTDPRQNILSYSPWLVKVKNEWRTFQVEEGRAQQGGKSVVAKLEGIDDRDLAREYIGCEIAILPEQLPATEEGFYWMQLIGCQVTSVEGEDLGQVTEIVETGAHDVLRVEKQSDAGLVSTLIPFVMETFILDVDVESKQIQVDWQLEDATES
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H4_ARATH
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDAVTYTEHARRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MURG_MAGSA
Sequence: MSTQKPLIALAAGGTGGHVFPAEALASVLLDRGYRLALITDKRGAAYGGTLGKLETFRISAGGIAGRGKLSALRSALELGLGLIQARSILGRIRPAAVIGFGGYASVPGMGAAALAGIPTAIHEQNAVLGRANRLLAGHVRRIATSFAEVSHVEPKLAPKLVHTGMPVRAAILASRDASYAGITAEGPIELLVLGGSQGARILSEVIPAALARLPEALRTRIRIAQQCRPEDLEGVRRAYDGTGIDATLDSFFADVPERLARAHLVIARAGASTVAELTTLGRPAILVPYPFAVDDHQTANAHAAEDCGGAWLMQQDSFTADSLAARLDSLFTHPEALVRTAVCARNVGRPDAAEALADLVVGLIPNESGA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: WHIA_BIFLD
Sequence: MALLDDVKSELAAFEGDSPAAIKAQAAAMIRFGGGLRPVQNTYVIQAVFTSLDVAEWLKNTLRNTFGHEAEVNHLTRQTPNGPVETYVVLVTRNVVALALQTGLVDRRKQQVRGLPSEVVNGSIAQIKAAWRGAFMARGFLSDPGKASFLEIACPTEEAAMALCGVARRLGIQAKHRTLRSSERVTLKDPDAIERMLKLMGATRSAREWTGKRSDGEARGKANRLANFDDANMRRSAKAAAEASEKVQHAFEVLGDNIPDNLRQAGQLRIDHVDKSLEELGKIAEPQITKDAIAGRIRRLLQLAEKTEKARAAEGK
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: URE3_KLEP3
Sequence: MELTPREKDKLLLFTAALVAERRLARGLKLNYPESVALISAFIMEGARDGKSVASLMEEGRHVLTREQVMEGVPEMIPDIQVEATFPDGSKLVTVHNPII
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PKHA7_MOUSE
Sequence: MAAAVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASFFIDHNQQTTTFRHPVTGQFSSENSEYVLREEPHPHMSKPERNQRPSSMVSETSTAGTTSTLEAKPGPKIVKSSSKVHSFGKRDQAIRRNLNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQMEHSGMRTYYFSADTLEDMNAWVRAMNQAAQVLSRSSLRRDVDKVERQAMPQANHTDACQECGHVGPGHSRDCPRRGYEDSYGFNRREQEEERFRAQRDPLEGRRDRSKARSPYLPAEEDALFVDLPGGPRGQQAQPQRAEKNGVPPYGLGEQNGTNGYQRTAPPRANPEKHSQRKTGLAQAEHWTKAQKGDGRSLPLDQTLPRQGPSQPLSFPENYQSLPKSTRHLSGSSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPIGAGSPEFTEQGRSRSLLEVPRSISVPPSPSDIPPPGPPRPFPPRRPHTPAERVTVKPPEQRRSVDISLGGSPRKARGHAAKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPMKIAESDIDVKLSIFCEQDRILQDLEDKIRALKENKDQLESVLEVLHRQTEQYRDQPQHLEKITCQQRLLQEDLVHIRAELCRESTEMENAWNEYLKLEKDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVMAGLSANKENYRVLVGSVKNPERKTVPLFPHPSVPSLSPTESKPALQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVMSPLQSPTKAKPQAEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDLKVELRSYVSEPELASLSGDVPQPSLSLVGSESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAENSSATFSRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGEKTGLLSARYLSQPLPGDLGSVC
What is the function of this protein?
Required for zonula adherens biogenesis and maintenance.  Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (By similarity).  Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011).
What are the official names of this protein?
Pleckstrin homology domain-containing family A member 7, PH domain-containing family A member 7, Heart adapter protein 1.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to zonula adherens, recruited via its interaction with CTNND1.
Protein: RS16_KARMG
Sequence: MSIKIRLQRKGRKKKAFYTIVVSNSRSPRNGKFLEKIGFYNPNTNPYTISINVDKAVNWLIKGAQPTCTVKSFFLKEGIYYKKYLLSGVKISKSEIEQKLKAWKEKKIILHK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: ISF1_YEAS2
Sequence: MIASEIFERGVQDPFCQDCDYEDETDVQSFLGSNDLNDFVNSKLASFSFENSSKSNNSHHSSSTNAGNTSRHIGNHTIGHHLRKIKTAPHHLYGFVPANSTNNSNEPIRPSPRRIRANSSTLIHQLSRQSTRQSSLGDAADSCFDHKCIKPRSRHSSCYGIPTHLYGLEKYVSSELDSLAVANDQSNDLTSPLTSVSTPASNSNSYLNLNSSSAAYPSSYLSNEKNNRLKLISHGKISSNNVPGHSGNLNHYHRERTPSNLRRESFSLLSNGSSSSPLQTRNNSYSNSLVKSPSNSSLNTSVASSNEESSPHTSNCLEERNPRRKSFIKLSLASSFSN
What is the function of this protein?
Could influence the NAM7/UPF1 function, possibly at the level of mRNA turnover.  Participates in mitochondrial biogenesis (By similarity).
What are the official names of this protein?
Increasing suppression factor 1, Mitochondrial biogenesis regulation protein 3.
What is the protein family that this protein belongs to?
Belongs to the ISF1/MBR1 family.
Protein: AHPD_METS4
Sequence: MTLDALLQSLPPYAKDVRLNFSSLGREETLTAQQRDGLLVACGLASRNPDLARALEAEAAPRLSPAALAAAKAAATVMAMNNVYYRFTHLASNPAYATRPAKLRMSSIGNPGVARADFELWSLAVSAINGCGRCIDAHEQVLREAGVGEEAIQAAVRVAAVVASLAVALESVRAAA
What is the function of this protein?
Antioxidant protein with alkyl hydroperoxidase activity.  Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
What are the official names of this protein?
Alkyl hydroperoxide reductase AhpD, Alkylhydroperoxidase AhpD.
What is the protein family that this protein belongs to?
Belongs to the AhpD family.
Protein: RL16_XANC8
Sequence: MLQPKRTKYRKMHKGRNDGLAWSGNAVSFGEYGLKATAHGQLTARQIEAARRTISRHVKKGGKMWIRVFPDKPITKKPIEVRMGSGKGNVEYWVAQIQPGRMIYEIEGIPEDIAREAFRLAAAKLSVTTTFVTRTVR
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: REPS1_HUMAN
Sequence: MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL
What is the function of this protein?
May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.
What are the official names of this protein?
RalBP1-associated Eps domain-containing protein 1, RalBP1-interacting protein 1.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit. Note=Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits.
Protein: RFBU_SALTY
Sequence: MIVNLSRLGKSGTGMWQYSIKFLTALREIADVDAIICSKVHADYFEKLGYAVVTVPNIVSNTSKTSRLRPLVWYVYSYWLALRVLIKFGNKKLVCTTHHTIPLLRNQTITVHDIRPFYYPDSFIQKVYFRFLLKMSVKRCKHVLTVSYTVKDSIAKTYNVDSEKISVIYNSVNKSDFIQKKEKENYFLAVGASWPHKNIHSFIKNKKVWSDSYNLIIVCGRTDYAMSLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNGALYVNPDDEKSWQSAIKNIEQLPDAISRFNNYVARYDFDNMKQMVGNWLAESK
What are the official names of this protein?
Protein RfbU.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: SHOT1_MOUSE
Sequence: MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDDDPATDTDAAAETCVSVQCQKQIKELRDQIVSVQEEKKVLAIELENLKSKLGEVMEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSMLAVEEYEELQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSLPDQQLLKALDENAKLIQQLEEERIQHQKKVKELEERLENEALHKEIHNLRQQLELLEDDKRELEQKYQSSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGNSAKKEKTTQPETAEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKAKPDSLKGSESAVDELKGILGTLNKSTSSRSLKSLGPENSETELERILRRRKLTAEADSSSPTGILATSESKSMPVLGSVSSVTKSALNKKTLEAEFNNPCPLTPEPGEGPRKLEGCTNPKVTFQPPSKGGYRRKCVGSENQAEPVVVLDPVSTHEPQTKDQAAEKDPTQFEEEGGETQPEYKEDSGGKTGETDSSNC
What is the function of this protein?
Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth (PubMed:23864681).  Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth.  Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone.  Also plays a role in regenerative neurite outgrowth (By similarity).  In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex (PubMed:23864681).  Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons (PubMed:23864681).
What are the official names of this protein?
Shootin-1, Shootin1.
What is the protein family that this protein belongs to?
Belongs to the shootin family.
What are the subcellular locations of this protein?
Perikaryon. Cell projection, axon. Cell projection, growth cone. Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, lamellipodium. Note=Localizes in multiple growth cones at neurite tips before the neuronal symmetry- breaking step. Accumulates in growth cones of a single nascent axon in a neurite length-dependent manner during the neuronal symmetry-breaking step; when absent from the nascent axon's siblings, probably due to competitive transport, prevents the formation of surplus axons. Transported anterogradely from the soma to the axon growth cone in an actin and myosin-dependent manner and passively diffuses back to the cell bodies. Colocalized with L1CAM in close apposition with actin filaments in filopodia and lamellipodia of axonal growth cones in hippocampal neurons. Exhibits retrograde movements in filopodia and lamellopodia of axonal growth cones (By similarity). Colocalized with KIF20B along microtubules to the tip of the growing cone in primary hippocampal neurons (PubMed:23864681). Recruited to the growth cone of developing axon in a KIF20B- and microtubule-dependent manner (PubMed:23864681).
Protein: Y2673_PELPD
Sequence: MSGHNKWSTIKHKKGAADAKRGKVFTKLIKEISVAAKLGGGDPAANPRLRTAVDKAKAENMPKDNIERAIKKGAGGMEGVTYEEIVYEGYGPGGAAVLVEVMTDNRNRSVSEIRSIFTKANGNMGEAGCVAWMFSKKGLITFDKGLDFEQLFEAAIEAGAEDVSEEDEQFEVTTDPSSFIEVREALVAKGFSFANAEVTMIPQTMVALEGKQAESMLKLMDKLEDNDDVQNVYSNFDISADEMEKMM
What are the official names of this protein?
Probable transcriptional regulatory protein Ppro_2673.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPFN_SALPK
Sequence: MDWLAKYWWILVLVFLVGVLLNVIKDLKRIDHKKFLANKPELPPHRDFNDKWDDEEDWPKKDQPKK
What are the official names of this protein?
UPF0370 protein YpfN.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SLN1_YEAST
Sequence: MRFGLPSKLELTPPFRIGIRTQLTALVSIVALGSLIILAVTTGVYFTSNYKNLRSDRLYIAAQLKSSQIDQTLNYLYYQAYYLASRDALQSSLTSYVAGNKSADNWVDSLSVIQKFLSSSNLFYVAKVYDSSFNAVLNATNNGTGDLIPEDVLDSLFPLSTDTPLPSSLETIGILTDPVLNSTDYLMSMSLPIFANPSIILTDSRVYGYITIIMSAEGLKSVFNDTTALEHSTIAIISAVYNSQGKASGYHFVFPPYGSRSDLPQKVFSIKNDTFISSAFRNGKGGSLKQTNILSTRNTALGYSPCSFNLVNWVAIVSQPESVFLSPATKLAKIITGTVIAIGVFVILLTLPLAHWAVQPIVRLQKATELITEGRGLRPSTPRTISRASSFKRGFSSGFAVPSSLLQFNTAEAGSTTSVSGHGGSGHGSGAAFSANSSMKSAINLGNEKMSPPEEENKIPNNHTDAKISMDGSLNHDLLGPHSLRHNDTDRSSNRSHILTTSANLTEARLPDYRRLFSDELSDLTETFNTMTDALDQHYALLEERVRARTKQLEAAKIEAEAANEAKTVFIANISHELRTPLNGILGMTAISMEETDVNKIRNSLKLIFRSGELLLHILTELLTFSKNVLQRTKLEKRDFCITDVALQIKSIFGKVAKDQRVRLSISLFPNLIRTMVLWGDSNRIIQIVMNLVSNALKFTPVDGTVDVRMKLLGEYDKELSEKKQYKEVYIKKGTEVTENLETTDKYDLPTLSNHRKSVDLESSATSLGSNRDTSTIQEEITKRNTVANESIYKKVNDREKASNDDVSSIVSTTTSSYDNAIFNSQFNKAPGSDDEEGGNLGRPIENPKTWVISIEVEDTGPGIDPSLQESVFHPFVQGDQTLSRQYGGTGLGLSICRQLANMMHGTMKLESKVGVGSKFTFTLPLNQTKEISFADMEFPFEDEFNPESRKNRRVKFSVAKSIKSRQSTSSVATPATNRSSLTNDVLPEVRSKGKHETKDVGNPNMGREEKNDNGGLEQLQEKNIKPSICLTGAEVNEQNSLSSKHRSRHEGLGSVNLDRPFLQSTGTATSSRNIPTVKDDDKNETSVKILVVEDNHVNQEVIKRMLNLEGIENIELACDGQEAFDKVKELTSKGENYNMIFMDVQMPKVDGLLSTKMIRRDLGYTSPIVALTAFADDSNIKECLESGMNGFLSKPIKRPKLKTILTEFCAAYQGKKNNK
What is the function of this protein?
Histidine kinase that acts as an osmosensor at the plasma membrane.  Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment.  Under normal osmotic conditions, the histidine kinase autophosphorylates His-576.  This phosphate is subsequently transferred to Asp-1144, from where it is relayed to 'His-64' of the phosphorelay intermediate protein YPD1.  Under high osmolarity conditions, the histidine kinase is no longer active.
What are the official names of this protein?
Osmosensing histidine protein kinase SLN1, Osmolarity two-component system protein SLN1, Tyrosine phosphatase-dependent protein 2.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YJCH_ECOLI
Sequence: MNGTIYQRIEDNAHFRELVEKRQRFATILSIIMLAVYIGFILLIAFAPGWLGTPLNPNTSVTRGIPIGVGVIVISFVLTGIYIWRANGEFDRLNNEVLHEVQAS
What are the official names of this protein?
Inner membrane protein YjcH.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ICCG_TALVA
Sequence: MDLNLAKPITLRCGITLPNRLWKAAMTEEFADKRRLPGSEACLATYRVWANGGWGLVMTGNVDVDPAYLGSPGNIAVDSSIPREKTLAAWRAWAEACSQNGAKAIVQINHPGRQASFTKSIAPSAVPLNLGPGILPWMLRSLIYGTPREMTVDEIHDVIMKFAETARLAADAGFAGVEIHAAHGYLLAQFLSAASNKRTDAYGGSAKARAKIVIDIIHAIRSDVPKTFCVGIKFNSTDHQSETEMKDCLEQLHLISDAGVDFLEISGGTFENPTFNLGVSDQKAKVSTQTREAFFVDFAKSIRSELSGLPLMVTGGFRTRQGMETALVEDSCDVVGIARPAVLSPYLPRNIIFNRDVVDAEAIAHAEKIDTPTIAKWMGIKAIGVGAETIWYIKKIQNLGSIETEL
What is the function of this protein?
NADH-dependent flavin oxidoreductase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:30905148).  IccA to iccE are sufficient for ilicicolin H biosynthesis and the roles of the remaining enzymes, iccF, iccG and iccH within the pathway have still to be determined (PubMed:30905148).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iccA with the partnering trans-enoyl reductase iccB since iccA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iccC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iccD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  Finally, the epimerase iccE converts 8-epi-ilicicolin H into ilicicolin H via epimerizationd (PubMed:30905148) (Probable).
What are the official names of this protein?
NADH-dependent flavin oxidoreductase iccG, Ilicicolin H biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
Protein: PLSX_AQUAE
Sequence: MLRIAVDCMGGDYAPLEIVRGCILAAKELGYKIYLVGDKEQIIPILEKAKEHNNSLLEVVHAPDKVEMHEPPSNVLKKKNSSLYVAGMLVRKGEADGLVSAGNTGAVLAVGKFIVGAEEEVERPSIGVALPNPKGKTVLIDVGANVDCKPKHLVQFAVIGHTYAEEILGIKNPRVGILSIGEEEGKGNELVKETYPLLKATKLNFKGNAEGRDIYAGTFDVIVCDGFVGNVILKASESLGLAVVQMIKEEIKRSILAKLGALLLMPALNRFKKKADFAEYGGIPLLGAKKPVIITHGRANAKAIKNAVRVAGEFLNTDFNKKLVYNLKTLIPEGVKV
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RS18_PSYA2
Sequence: MARFYRRRKFCRFTAEGITHIDYKDVELLKQYISDNGKIVPSRITGTSTKYQRQLATAIKQARYLSLLPYTDNHQG
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: DEF_PSELT
Sequence: MVKKIRLLGDPVLRKKSKNVERVDETTISLIKDLFETMYATDGIGLAAPQIGVSLRIFVMDDGKPRVFINPEIIYKSEEKEIAEEGCLSVPEVFEDVERSKEVTVRYMNEHGEEVEESFVDYSARVVQHEYDHLQGVLFIDLIPSSRRFAIRKKLIEIVRQSQKTDYAERP
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: AMPG1_RICCN
Sequence: MLNNSRLCIIWLFGLISGFNLMITGNTLNYWLAKEDIALQTIGILSFITLPYSINFLLAPIFDAVQIKYLNKIFGHRLSWICLTSSALIFLIYIFSFLDPSTNLLLFAFTALIISFFSAAQDTILSALRTEIVPKESLGFTSGIYIFGYRVGMLLAGSGAIYLSIYLTFNEIYKIFAGLVFIYLILLIVGIKYCDLNENIHIQIIKNDIKNNQNKKNIINFIYNALKPIGSVYFIILILIFLVLYRLPDNLINVMINPFLLHLEYDAFEIASVGKFCGVVGAIIGGLVGGVIMKHKNILNSIFLFGIIHALGHILFIFLEINGKNSLLLFITIGIASITGGMTMTAYIAFISALCQGKFRATQYSFLSSMMGISRSIFPIISGYMVVNFGWQNFFLFTTIITIPSLLILLKIKTKLQ
What are the official names of this protein?
Putative transporter AmpG 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS7_AKKM8
Sequence: MARRKRVYRKIERRDPRYDSALVGKLISKVMLDGKRSLAERIVYAAIDMANEGTDSIDPLEVITRAIENAKPRVEVKSRRVGGATYQVPLEVDPARSESLAMRWIVNYARNRKGVPMHKALANEIKEAANNQGSSVRKRDDVHKMAQANRAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.