PharMolix/UniProtQA huggingface dataset:
Protein: NFXB_PSEAE
Sequence: MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS
What is the function of this protein?
Confers resistance to guinolones.  May negatively regulate the expression of genes that are associated with cell permeability to drugs.
What are the official names of this protein?
HTH-type transcriptional regulator NfxB.
Protein: TIG_BIFLO
Sequence: MKISVRNLEPTKVKLTVTVEPEELNPYLDAARKEIAKQVNVPGFRKGHVPGKIIDQRIGFAAVAGEAVNDAVPELYSKALEEKKIRPMAQPEFDVQDVPQSANDETKLKFTATVERRPDIELPEIDGLEIAISKPEVKDEDVDKRLEALRQRFGTLVGVDRPAAKGDFANIDLTAEIDGETVDSQEGVSYELGSNTMLDGLDEALDGLSAGEETTFEGTLEAGEHEGQKATVKVKVNSVKAEELPELNDEFASEASEFDTLDELKADIRKAAAQDAEGRQATEARDAFIAKLQEGLEIPVPKGVKANMVEEQLKGMTPDPEKATKEQKAQAEETVEKDLRDQMVLDALAEKLDVQVSQSDVFNFLASIAQQYGMDPNNFIQAIIKNGQLGSAVQEVGRSKGLLAGMRAVKFTADGEVVDLSAFLGEAAEDEESESVEAASAAAAVADELSAKDDAKDAE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: BSHC_CYTH3
Sequence: MSAFSVEKIGLQDSQQFSKLFIDYLAQQEHIQPLYTFYPDMAGLETAIEKRSKQPINRTVLVERLKAQYKDLPVSEKVQQNIERLASEHTFTITTGHQLCLGTGPLYLILKTLSCVKLCEALKTKHADNEFVPVFWMASEDHDAAEINHFYVFGKKYTWETTQTGAVGRFTTTGISEVLETIKDIPAWLKDAYQSSVTLAEATRKVMHQLFAEYGVVVIDGDDAALKKEFTAVIEKELFEQPAVAVMNQTNRSIERHGYSIQVNPRDINLFYVKDSLRERIEKQGERFVVLHTDVSFSAGEIKKEVADHPERFSPNVVLRPLYESTILPDIAYVGGPGEIAYWLQLKEVFAVYNTFLPAIFPRMFSGVITKQQCVKLEKAHVTVAELFLSEFDLKQVVVSRSIQEEISIEAEAGKITAAFDTIASIAATVDGSLQSWAQAEKAKALKQLEDIEKKLRKAEERKHDDVIKSVLGIRDKILPNGKLQERQESVFTFLVNDAQLIEKLYQSLDPCTFNIQMCCYE
What are the official names of this protein?
Putative cysteine ligase BshC.
What is the protein family that this protein belongs to?
Belongs to the BshC family.
Protein: EPFL5_ARATH
Sequence: MGVVLPTLIVYAFLLFFSSSSAASLQRPSGGLGQGKKEIARSGLPGQIVDQKRLGGPGSVPPMCRLKCGKCEPCKAVHVPIQPGLIMPLEYYPEAWRCKCGNKLFMP
What is the function of this protein?
Controls stomatal patterning.  Mediates differentiation of stomatal lineage cells to pavement cells and stomatal development inhibition (PubMed:23748792).  TMM (AC Q9SSD1) functions to dampen or block CLL1 signaling.  Acts as growth-regulatory ligand for ERECTA family receptors.  Promotes fruit growth and fertility (PubMed:22474391).
What are the official names of this protein?
EPIDERMAL PATTERNING FACTOR-like protein 5, EPF-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the plant cysteine rich small secretory peptide family. Epidermal patterning factor subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YI029_HUMAN
Sequence: MKLAKTAVLDPATYTSFSPGLSTCSSSQPPGDRRKGLLGCVGSGHCPLPTPAQFPKVQRPPTLLGGKNTSTQTTLHPVI
What are the official names of this protein?
Putative uncharacterized protein LOC401522.
Protein: QUEF_GLOVI
Sequence: MSDLPVAPTPAEPVKYGERAIEAGQLITFPNPRPGRDYDIHITLPEFTCKCPFSGYPDFATIYLTYVPHEKVVELKALKLYVNSFRDRYISHEEVVHVVLDDFVAAADPLRVQIKGDFNPRGNVHMVVEARHTRPGT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_PSEA8
Sequence: MTAQLIDGKAIAANLRQQIAQRVTERRQQGLRVPGLAVILVGTDPASQVYVAHKRKDCEEVGFLSQAYDLPAETSQDDLLALIDRLNDDPAIDGILVQLPLPAHLDASLLLERIHPDKDVDGFHPYNIGRLAQRMPLLRPCTPKGIMTLLASTGADLYGMDAVVVGASNIVGRPMALELLLGGCTVTVTHRFTRDLADHVSRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINRQADGRLVGDVEYEVAAQRASWITPVPGGVGPMTRACLLENTLHAAEHLHD
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: YKT9_CAEEL
Sequence: MSSTEQSTSRATTSTNCTKTEETVDVIGTVEVTECNWTMTEESRDAIIRIIKERMSHTEYQYVDDDVPNSERCHFCMKRKGRWMGDDCSDHSSLCKHCCYEMIRDSIKDYKSGPLYARCPQCFRNISSLTRRKRRLTSEGHDENCPAPMVPMVNAEHSISLCDYTTSMMGGGQVNKGFESSSSL
What are the official names of this protein?
Uncharacterized protein C07A9.9.
Protein: SYD_STRPG
Sequence: MKRSMYAGRVREEHIGTTITLKGWVSRRRDLGGLIFIDLRDREGVMQLVINPEEVSSDVMATAERLRSEYVIEVEGFVEARQQANDKLATGMVELKVSALTILNTAKTTPFEIKDDAEVSDDTRLRYRYLDLRRPEMLENFKLRAKVTHSIRNYLDDLEFIDVETPMLTKSTPEGARDYLVPSRVSQGHFYALPQSPQITKQLLMNAGFDRYYQIVKCFRDEDLRGDRQPEFTQVDLETSFLSEQEIQDIVEGMIAKVMKETKEIDVTLPFPRMSYDVAMNSYGSDKPDTRFEMLLQDLTVTVKGIDFKVFSEAPAVKAIVVKGNADRYSRKDIDKLTEFAKQFGAKGLAWVKVTDGQFSGPVAKFLTAIETELSSQLKLAENDLVLFVADTLEVANNTLGALRNRIAKDLDMIDQSQFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPTPESAHELEGDLAKVRAIAYDIVLNGYELGGGSLRINQKEMQERMFKALGFTADEANDQFGFLLEAMDYGFPPHGGLAIGLDRFVMLLAEKDNIREVIAFPKNNKASDPMTQAPSLVSENQLEELSLQIESHD
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAA_PSYIN
Sequence: MHYNTSLLCDIYADTVDVVEPLLTNFGGRNSFAGEVVTIKCFESVGLIYKALEENGLGKVLLVDGGGSLRRALVNAHIAELAVENGWEGIVVNGCVREVDLLEDLDIGIQAITAIPVGAEDTQIGEVNSPVNFAGVTFLPEDILYADSTGIIISPEPLNAEALTESDEIA
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEND_PROMH
Sequence: MSNSSFNRQWAKVILETLTRHGLRHICIAPGSRSTPLTLAAAANHKLICHTHFDERGLGHLALGLAKATQQPVAVIVTSGTAVANLYPALIEAGLTGERVIFLTADRPPELINCGANQAIRQQGIFASHPSETLSLPRPTADISARWLVSTLDNAMNNLVHGALHVNCPFAEPLYGDDIEHDTPWTQALGKWWQSDKPWLQETLSPSVTTHPQWDRLRQKKGVVIAGRISAKEGIAVAKWASKLGWPLLGDVLSQTGQPLPCADLWLNNPQVKAELNQAEIVIQFGSSLTGKRLLQWQANCSPQMYWVIDAIPGRLDPGHHQGEKFTLSPSQWLTAHPAIDNLPWALSLSHIATQTYQHVTEVTDYFGEAQVAHQLDHLLPHNGQLFVGNSLIVRLIDAFAQLPQGYPVMSNRGASGIDGLLSTSAGVHRATQKPTLTILGDLSALYDLNSLALHQQVYAPNVVIIVNNNGGQIFSMLPTPMAERERFYCMPHALNFKHAAAMFGLDYVAPNCWDDLFTTVTACWQGEAKTTLIELIVNETEGAETLNQLVKQVTAYDFSL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: MURA_PORGI
Sequence: MASYVIEGGNSLKGEILVQGAKNEALQIISATLLTDQEVVVRNIPDILDVNNLIDLLRNMGVKVKRPTRDTCVFQADNVNLDYIKSEQFLEKSRALRGSVLLVGPLISRFGYAIFPKPGGDKIGRRRLDTHLVGIQALGATCDYHSDMQAYELTASRLSGTYMLLDEASVTGTANILMAAVLADGITTIYNAACEPYLQQLCKMLLSMGAHIEGVGSNLLRIEGVQSLHGCEHKMLPDMIEVGSFIGMAAMTASELLIKDVSVPDLGIIPASFRRLGIAVEQQGDDLFIPKQEHYEIETFMDGSIMTIADAPWPGLTPDLLSVFLVVATQAKGSVLIHQKMFESRLFFVDKLIDMGAQIILCDPHRATIIGLDKRVPLRAATMVSPDIRAGIALLIAAMSAEGTSIIHNVEQIDRGYQSIDTRLNAIGARISRL
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCAL_STAEQ
Sequence: MKSVGLITEYNPFHNGHLFHATLSKQRSETNVTIAIMSGNFVMRGEPAIYHKFKRTEMALSAVDLVVELPLIGSLSSSDTFAEIAIKTAQYLDIDIISFGSESASLKDLQYLATQMIDYEKHPDFKEKLKQGKSYPRILSELTHNDTLLQSPNNILGISYLKAMQQFAPHMSALTIKREGSLHHQKVIDHHHFASGTSIRRSLMNDNVDWKNVVPNQIQSLYCKPHTTVEDTFPFIKHQLITQPKESLHSIYTINEGFENRLQTMIHRSDSFESLLSNLNTKRYTQTYIQRVLMNVLLNITKDDVNKEINAVRVLGMSEKGRSYLKYLKANYPNRHYITNVNQKTAHYFKNEIKATHVYNLLSNQSQTDFNTPLVRI
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMD1_HUMAN
Sequence: MAAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQILKTLSEVEESISTLISQPN
What is the function of this protein?
Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins.  Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237).  Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation.  Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074).  Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529).  Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L.  Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370).  Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833).  Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380).  Plays a role in copper ion homeostasis.  Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947).  Can bind one copper ion per monomer (PubMed:17309234).  May function to facilitate biliary copper excretion within hepatocytes.  Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794).  Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141).  Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner (PubMed:28604741).
What are the official names of this protein?
COMM domain-containing protein 1, Protein Murr1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endosome membrane. Cytoplasmic vesicle. Early endosome. Recycling endosome. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.
Protein: RUN3A_PONAB
Sequence: METSFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS
What is the function of this protein?
May act as an effector of RAP2A in neuronal cells.
What are the official names of this protein?
RUN domain-containing protein 3A.
What is the protein family that this protein belongs to?
Belongs to the RUNDC3 family.
Protein: SYE_FRACC
Sequence: MGSGRVRVRFAPSPTGIFHVGGARSALFNWLVARRAGGDFVLRVEDTDASRNRPEWTDGIISALDWLGISPGGYEGPVLQSSRADRHRAAAERLHAEGLAYYCDCTREALAERTGNAQRGYDGFCRDRGLAPGPGRALRFRTPDDGVTIVEDLIRGTPEFPNETIEDFVVARADGSAVFLLANVVDDLEMGITHVIRGEEHLSNTPKQQLLWAALGADAPPVWAHVPVIVNEKRQKLSKRRDKVALESYRDEGYLPAAMKNYLMLLGWAPPGEDEIVPWETIESTFDLADVKPSPAFFDEKKLKAFNGEYIRRLSVAEFIEAVRPWLSAPAAPWEPAAFDADAFAALAPLAQSRVSVLSEIVPMVDFLFLPEAPIDDAAWAKAMKGPAAELLADVHDLYDKIEWEAETLKAGLTEVGERHGLKLGKAQAPVRVAVTGRSVGLPLFESLEALGRETTLRRLAEARERLTGG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUF60_CAEEL
Sequence: MEENSADIENRPVAAFRPAVSVPMPVLPQDGEVFVGPGGKKDAQKIGLGLSKLSSKRKDDIQMAKKYAMDISIKQILLRQQKQQQENQQRQQMYSQALSIMSRIYVGSISFEIREDMLRRAFDPFGPIKSINMSWDPATGHHKTFAFVEYEVPEAALLAQESMNGQMLGGRNLKVNSMMFQEMRLPQNMPQAQPIIDMVQKDAKKYFRVYVSSVHPDLSETDLKSVFEAFGEIVKCQLARAPTGRGHRGFGYLEFNNLTSQSEAIAGMNMFDLGGQYLRVGKCVTPPDALTYLQPASVSAIPASVSVACAAITAKVMAAEAAAGSSPKTPSESGGSRAASPAPRAQSPATPSSSLPTDIENKAVISSPKKEPEEIEVPPLPPSAPDVVKDEPMEIEEEEEYTIPEEKPKPVAIVPPPGLAIPSLVAPPGLIAPTEIGIVVPNPSFLAQQQQKIEEKIEEEEEARTERVKLSTSQRKKMKREKLNQMTFEEKMAQVLGQQKAVQNQRMADPVTFGALDDTVAWKDPSNEDQTSEDGKMLAIMGPGRGGDNVASMALALMDGGSSLMLANNAKAKEAAAALALEPKKKKKVKEGKKIQPKLNTAQALAAAAKAGEMSDALKNEVMNSEDASLASQEGLEIRGNDARHLLMTKLMRTNRSNVIVLRNMVTPQDIDEFLEGEIREECGKYGNVIDVVIANFASSGLVKIFVKYSDSMQVDRAKAALDGRFFGGNTVKAEAYDQILFDHADYTG
What is the function of this protein?
DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation (Probable).  Ensures the correct splicing of genes involved in immunity to promote longevity in response to infection by pathogenic bacteria such as S. aureus (PubMed:32538777).
What are the official names of this protein?
Poly(U)-binding-splicing factor rnp-6, 60 kDa poly(U)-binding-splicing factor rnp-6.
What is the protein family that this protein belongs to?
Belongs to the RRM half pint family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COA3_PICGU
Sequence: MKFPADSNLILIMPGHARYRDPKTFEMSPALVRVRAPYFWRNTLAFIVVGSIPLGVYAYTWSFLNKDEFSDIPIPPVSDEELAKLKKEYANKK
What is the function of this protein?
Required for assembly of cytochrome c oxidase (complex IV).
What are the official names of this protein?
Cytochrome c oxidase assembly factor 3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COA3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: SEC23_PICST
Sequence: MNFEEAEDINGIRFAWNALPSTKVEAGKVVVPTGVIYTPLKQREDLPVAVYDPIFCSNQNCKSILNPYCTIDPSGFWRCPLCSYRNPLPAHYQGVTPENLPLELQPGSSTIEYITARPVQNPPIFFLLIDLCQDEDNLAALKETLIVSLSLLPPNALIGLITYGTMVQVHDLGSEKISKSYIFRGDKEYTEKQISDMLNRPTSTPQGQLPQFANSLTRFFLPVEDVEFQLTSILENLGKDPWTVANGDRPLRSTGSALNVAANLLGSTFPGFGARIMLFSAGPGTLSPGLIVGPQLKEPIRSHSDIDKDNAKHFKKAVKFYDSIAAKMVKNAHTVDIFAGCYDQIGMLEMKNLCNLTGGTLLLSDAFTTSIFKQSFLRLFNKDHEGYLLMGFNGTFDVKTSKELKISGLIGHASSMNVKTQNVSENELGIGGTSQYRLCSVSPQHSYAVFFDVVNTQSLPQNAQSYTQFITHYQHASGTYRIRVTTVSNFLTSDEQTLTNSFDQEAAAVLMSRVTLFKSEQDDGADVLRWIDRMLIRLCQKFADYRKDQEESFRLGPQFQLYPQFIYYLRRSQFLQVFNNSPDETAFYRHVLLTEDTNNSLIMIQPTLTSFSLDSEPEAVLLDSVSIKDDKILLLDTFFHILIFHGKTIAQWRKAGYQNQPEYENFKLLLEEPKQEAAELLVDRYPLPRFIDTEEGGSQARFLYSKLNPSITYNSSEFATNNGAIVLTDDVSLQVFMGHLQKLVVSGSS
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC23.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RF1_ALIFM
Sequence: MKASIRVKLETLVERYEEVQHLLGDPDVIGDQNKFRALSREYSQLEEVTQCFQAYEQAQEDLVAAQEMAQEDDEEMREMAQEEIKDAKEAIERLTDELQVLLLPKDPNDERNCFLEIRAGAGGDEAGIFAGNLFRMYSRFAEKKGWRVEVMSSNEAEHGGYKEMIAKVSGEGAYGVLKFESGGHRVQRVPETESQGRVHTSACTVAVMAEIPEADLPEIKAADLKIDTFRASGAGGQHVNTTDSAIRITHLPTGTVVECQDERSQHKNKAKAMSVLAARIIQAEEARRAAAVSDTRRNLLGSGDRSDRIRTYNYPQGRVSDHRINLTVYRLNEVMEGDLGCLIEPVVLEYQADQLAALAEQN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMC_ACIB3
Sequence: MDPRSEVILRQQDYLKGRVLLINAPNDALVSQLPTEIDASVWTWNYADYQGFVNTGTPAHFSVEFPSQEFDQAIIFVPKSKELLNYILHVVMSHLKTDQSVFLVGEKKGGVERAAKQLQNFGTILKLDSARHCQLWHLKIEKIEKIKPLESWLKTYTVQVNGQELTICALPGVFSQTHLDVGTAVLLPYLNQVKSGRIADFGCGAGIISCYLAKANSSNIIHALDIDAFALQSTEMTFSRNGIGSDQLRLQPVTGIADAPTELDAIVSNPPFHQGIHTNYDASEGLCQNAKKHLKASGELWIVANRFLNYPILIEKHFGQCEIKTDLQGFKVLYACA
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOI_MARMM
Sequence: MGRIQQAFRGALLMDFWSAFGLGMRYFFAKKATLNYPFEKGPLSPRFRGQHALRRYANGEERCIACKLCEAICPAQAITIEAEPRSDGSRRTTRYDIDMTKCIYCGYCQEACPVDAIVEGPNFEFAAETREELFYDKAKLLENGDRWEREIAKNLELDAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LTMD1_BOVIN
Sequence: MALSRVCWARAALWGSAVPPGLYVVRRLQFVRSGLTWGAPRSSKLHLSPKADVKSLISYVVTKTKVINGKYHRFLGRHFPRFYVPYTIFMKGLQMLWADGKKARRIKTNMWKHNIKFHQLPYREMEHLRQFRRDVTKCLFLGILSIPPFANYLVFLLMYLFPRQLLIRHFWTPKQQIDFLDIYHALRKQSHPEILCYLEKVVPLISDAGLQWHMTELCTKMQRGTHPAVHDILALRECFANHPLGMDQLRALQMKALCRAMLLTPYLPSVLLRHRLKTHTTVIHQLDKALAKLGVGQLTAQEVKSACYLRGLNSTHIAEERCRTWLGEWLQISCSLKETELSLLLHNVVLLSINYVGSRR
What is the function of this protein?
Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes.  In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity).  May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (By similarity).  Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (By similarity).
What are the official names of this protein?
LETM1 domain-containing protein 1.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: NRDI_ECOBW
Sequence: MSQLVYFSSSSENTQRFIERLGLPAVRIPLNERERIQVDEPYILIVPSYGGGGTAGAVPRQVIRFLNDEHNRALLRGVIASGNRNFGEAYGRAGDVIARKCGVPWLYRFELMGTQSDIENVRKGVTEFWQRQPQNA
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: PSAE_NOSS1
Sequence: MVQRGSKVRILRPESYWFQDVGTVASVDQSGIKYPVIVRFDKVNYAGINTNNFAVDELIEVEAPKAKAKK
What is the function of this protein?
Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase.
What are the official names of this protein?
Photosystem I reaction center subunit IV.
What is the protein family that this protein belongs to?
Belongs to the PsaE family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: CLPP_ECO57
Sequence: MSYSGERDNFAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQMLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAGAKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVKGRMNELMALHTGQSLEQIERDTERDRFLSAPEAVEYGLVDSILTHRN
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.