PharMolix/UniProtQA huggingface dataset:
Protein: DAPEL_BACSU
Sequence: MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEIEKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTIALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELPVGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTDPLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFRCKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGFMFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN
What is the function of this protein?
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
What are the official names of this protein?
N-acetyldiaminopimelate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
Protein: AROE_ALIF1
Sequence: MDKYAVFGNPIKHSKSPFIHTLFARQTMQDLEYSAIEAPINGFVESVTAFFSQQGKGCNVTVPFKEEAFQFADQLTERAKLAGAVNTLKKLDDGIILGDNTDGEGLVQDLLQYQVPLEDKHILLIGAGGAARGVILPLLKQNPASITLVNRTYEKAKQLAELFSPYGRIEAKKMSDINKGFDVIINSTSASLSGELPQIDPVIFSGGAISYDMMYGSGKTIFNQWALKNDAYQAYDGLGMLVGQAAESFTVWRGLRPGSKQILRELRKT
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: DNLJ_METPP
Sequence: MSDRAEDPAARAAQLREQLEYHAHRYYVLDAPEIPDAEYDRLFTELQALEAAHPGLRTPDSPTQRVIGAVLEGLSAVRHAVPMLSIKTETDTTPTGALKFDAAVRNALKLPPDAPPLRYAAELKFDGLAINLRYQAGRLVQAATRGDGETGEDVTHTVGTIESVPKQLRGITAPVLEVRGEVFMRRDDFEALNERQREAGLKTFVNPRNAAAGIVRQLDASIARQRPLSFFAYGLGDVQGWDVPPTHAGLLDALAALGLPVDAHRTVVEGGEALAAFHAGIAAERDALPFDIDGVVYKVDERALQQQLGFKSREPRWAVAHKYPAQEQSTQLAGIEIQVGRTGKLTPVAKLQPVFVGGTTVSNATLHNRFELRRKGIRIGDTVIVRRAGDVIPEVVGRVPVPRTAYIPNFRMPRACPVCGSQALRERGSVDYRCSGGLFCAAQRKQALLHFAGRRMMDIEGLGDKLVEQLVDGGIIRTLPELYRLGVAKLVALERMGDKSAANLVAALEASKATTLARFLFSLGIRHIGEATAKDLARHFGALDRVMDASVEQLLEVNDVGPVVAQSLRTFFDQPHNREVVEQLRAAGVHWDEHSGEADLTPRPLAGKTFVLTGTLPSLGREAAKELIEAAGGKVAGSVSKKTDYVVAGEEAGSKLEKAQALGVAVIDEAALRALLD
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PRDX5_MOUSE
Sequence: MLQLGLRVLGCKASSVLRASTCLAGRAGRKEAGWECGGARSFSSSAVTMAPIKVGDAIPSVEVFEGEPGKKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAGALKAKGAQVVACLSVNDVFVIEEWGRAHQAEGKVRLLADPTGAFGKATDLLLDDSLVSLFGNRRLKRFSMVIDNGIVKALNVEPDGTGLTCSLAPNILSQL
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
What are the official names of this protein?
Peroxiredoxin-5, mitochondrial, Antioxidant enzyme B166, AOEB166, Liver tissue 2D-page spot 2D-0014IV, PLP, Peroxiredoxin V, Prx-V, Peroxisomal antioxidant enzyme, Thioredoxin peroxidase PMP20, Thioredoxin-dependent peroxiredoxin 5.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx5 subfamily.
What are the subcellular locations of this protein?
[Isoform Mitochondrial]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform Cytoplasmic+peroxisomal]: Cytoplasm. Peroxisome matrix.
Protein: TRHO_BURVG
Sequence: MTIVNLAAYHFVSLDAIEQWRPLVTARCNELGLRGTILLAPEGINLFIAGPREATDAFVDYLRHDPLFEGKFATLQFKESLSDSQPFRRMLVRLKREIITMKKPAIKPELGRAPSVDARTLKAWLDRGHDDDGRPVVMLDTRNAFEVDVGTFDDALDYRIDKFSQFPEVIDANRADLEGKTVVSFCTGGIRCEKAAIHMKEIGIDHVYQLEGGILKYFEEVGGAHYHGDCFVFDYRTALNPQLQPTESVTCFACRAVVTPQAQQSPDYVPGKSCPACAQAAAAA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: HST2_SCHPO
Sequence: MVKNTVKHVDSSKHLEKVASLIKEGKVKKICVMVGAGISTAAGIPDFRSPETGIYNNLQRFNLPYAEAVFDLSYFRKNPRPFYELAHELMPEKYRPTYTHYFIRLLHDKRLLQKCYTQNIDTLERLAGVPDKALIEAHGSFQYSRCIECYEMAETEYVRACIMQKQVPKCNSCKGLIKPMIVFYGEGLPMRFFEHMEKDTKVCDMALVIGTSLLVHPFADLPEIVPNKCQRVLINREPAGDFGERKKDIMILGDCDSQVRALCKLLGWSDELEKLIDTSVETLTEEISLLSVDSTIEKNASEQKKDDNSVNPFTKIEEKKKDEVTLLVSDDE
What is the function of this protein?
NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
What are the official names of this protein?
NAD-dependent protein deacetylase hst2, Homologous to sir2 protein 2, Regulatory protein SIR2 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LMAN2_MOUSE
Sequence: MAAEAWLWRWGWGWGQRCPGRPGLPGPGPSPTTFLHLLLLLGPVAADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRLTPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVMVNNGSLSYDHSKDGRWSELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIISIKLFQLTVERTPEEESIDWTKIEPGVNFLKSPKDNVDDPTGNFRNGPLTGWRVFLLLLCALLGVVVCAVVGAVVFQKRQERNKRFY
What is the function of this protein?
Plays a role as an intracellular lectin in the early secretory pathway.  Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans.  Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).
What are the official names of this protein?
Vesicular integral-membrane protein VIP36, Lectin mannose-binding 2, Vesicular integral-membrane protein 36, VIP36.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type I membrane protein.
Protein: RL35_CLOB1
Sequence: MPKMKTKRAAAKRFKVTGTGKLKRAKAFKSHILTKKSRKTKRNLRKAGYVSESQEKVMKKVLPYL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ANMK_AGRRK
Sequence: MEPIWAVGLMTGTVLDGNIDVALIKTDGERIAEFGPYALAPYPDWIRRLLEETLAQARVWNFNGPEPAIFKEAEEALTRAQSAAVKELVEGFGLTMADIGVVGFHGQTVLHRAPQKGRLGDTRQLGDGELMHSILGTKVAYDFRSADVRAGGQGAPLAAAYHTALLRSAGTGDDTAILNLGGVANITWSDGEGNFVAFDTGPANAPLNDFIKSHGLGEMDRDGALGRAGKVDETRLAKLLEHPYLSAAYPKSLDRFDFGASMADGLSVEDGAATLSAFTASAVGKALDLLPRRPKKLVVSGGGRHNPTIMSMLETHAGVTPIGAEMFGWRGDAVEAECFAFLAVRVLRGLPISFPGTTGVPAPMRGGRLAE
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: ENO_BAUCH
Sequence: MSKIVKVIGREIIDSRGNPTVEAEVHLHGGFIGLAAVPSGASTGSFEALELRDGDKSRFLGKGVTKAVSAVNGPIAEALIGNNAKYQECIDKIMIKLDGTENKSQFGANAILAVSIATAKSAAASKGIPLYEHIAELNGTAFQFSMPLPMINIINGGKHADNNIDIQEFMIQPVSAKTIKEAIRIGAEVFHYLAKVLKANGMHTTVGDEGGYAPNLDSNTEVLDLITEAVEKAGYILGKDITLAIDCAASELFDPLTNKYLLKGEGKIFTSQEFTDYLNILTKKYPIISIEDGLNESDWDGFMYQTKVLGNKIQLVGDDLFVTSAKILQQGIEKGIANSILIKLNQIGTLTETMAVIKIAKNAGYTTIISHRSGETEDTTIADLAVGTSAGQIKTGSMSRSDRLAKYNQLLRIEEQLGKKAPFNGLKEVQSQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: ATPA_BUCAI
Sequence: MRLNSTEISKLIKERIAQFEVFNQSYNEGSIISVSDGIIKINGLSNVMLGEMILLPNNEYAIALNIERDTVGAVVMGPYIHISEGAKVRCTGKILEVPVGDNFLGRVVNALGFPIDGKDSIQNDGFFPVEADAPGVIDRKSVNQPIQTGYKVIDSMIPIGRGQRELIIGDRQTGKTALAIDTIINQKQSGIKCIYVAIGQKLSTIINVVKKLEENNALFNTIIVVASASEAASLQYLAPYSGCAMAEFFRNKGEDSLIIYDDLSKHAVAYRQISLLLRRPPGREAFPGDIFYLHSRLLERASRVSMEYVQKITKNKITGKTGSITALPIIETQSGDVSAFVPTNVISITDGQIFLESNLFNSGIRPAVNPGISVSRVGSAAQTTIIKKLSSGIRTALAQYQELAAFSQFSSDLDDTTRKQLNHGQKITELLKQKQYSPISIAEQALILFVAENNFLDDISIDKITKFEKEILIYAHNYYFDLMEEINKTGDFNIVIKDKFIKLITEFKKNQF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: XDH_SCHPO
Sequence: MTSMSGASPVIHWGFLGAGSIAAVFAKDLVGVPERHKVQHEIVAVATRDSEHRASSFAKNHCAPCKPKAYGSYEELVKDDKVDIVYISSTHPQHYEVVKLALLNDKAVLCEKPLTINYPEALELVELARARNLFFAEGFWIRFYPIVKAAKTLLHEDRVCGDHFRLFVDFSQDFRFRELPSESRLRTVSLGAGVLLDMGVYPLTWSRLLLYDDPKNEKQEPTVSSNALTFEDHNGDIGDYTTAVTLVFPKTESIAMLCTSMDRGKMSDDFLKLDGENGNQLFISGDCYRPQSIKLIRASGETEVFDFSFDDATGFFYEQDAVAECLLKNMKEAPEIPHEETLKMMQLTDQIRRQINVTYPADLRYTTA
What is the function of this protein?
NADP-dependent D-xylose dehydrogenase catalyzing the oxydation of D-xylose into D-xylonolactone (By similarity).  May also display activity with other sugars.  May play a role in the regeneration of NADP(+) in the presence of these sugars (Probable).
What are the official names of this protein?
Probable D-xylose 1-dehydrogenase (NADP(+)), XDH, D-xylose-NADP dehydrogenase, Dimeric dihydrodiol dehydrogenase homolog, NADP(+)-dependent D-xylose dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GB_BHV1C
Sequence: MAARGGAERAAGAGDGRRGQRRHLRPGRVLAALRGPAAPGAGGARAALAAALLWATWALLLAAPAAGRPATTPPAPPPEEAASPAPPASPSPPGPDGDDAASPDNSTDVRAALRLAQAAGENSRFFVCPPPSGATVVRLAPARPCPEYGLGRNYTEGIGVIYKENIAPYTFKAYIYKNVIVTTTWAGSTYAAITNQYTDRVPVGMGEITDLVDKKWRCLSKAEYLRSGRKVVAFDRDDDPWEAPLKPARLSAPGVRGWHTTDDVYTALGSAGLYRTGTSVNCIVEEVEARSVYPYDSFALSTGDIIYMSPFYGLREGAHREHTSYSPERFQQIEGYYKRDMATGRRLKEPVSRNFLRTQHVTVAWDWVPKRKNVCSLAKWREADEMLRDESRGNFRFTARSLSATFVSDSHTFALQNVPLSDCVIEEAEAAVERVYRERYNGTHVLSGSLETYLARGGFVVAFRPMLSNELAKLYLQELARSNGTLEGLFAAAAPKPGPRRARRAAPSAPGGPGAANGPAGDGDAGGRVTTVSSAEFAALQFTYDHIQDHVNTMFSRLATSWCLLQNKERALWAEAAKLNPSAAASAALDRRAAARMLGDAMAVTYCHELGEGRVFIENSMRAPGGVCYSRPPVSFAFGNESEPVEGQLGEDNELLPGRELVEPCTANHKRYFRFGADYVYYENYAYVRRVPLAELEVISTFVDLNLTVLEDREFLPLEVYTRAELADTGLLDYSEIQRRNQLHELRFYDIDRVVKTDGNMAIMRGLANFFQGLGAVGQAVGTVVLGAAGAALSTVSGIASFIANPFGALATGLLVLAGLVAAFLAYRYISRLRSNPMKALYPITTRALKDDARGATAPGEEEEEFDAAKLEQAREMIKYMSLVSAVERQEHKAKKSNKGGPLLATRLTQLALRRRAPPEYQQLPMADVGGA
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: DAPB_MYCSS
Sequence: MRVGVLGAKGKVGATMVQAVEAADDLTFTTGVDAGDPLSALVDTRTDVVIDFTHPSVVMDNLKFLIDNGIHAVVGTTGFTDERISQVQDWLADKPESAVLIAPNFAIGAVLSMHFAQQAARFFESVEVIELHHPHKADAPSGTAARTAKLIAAARKDMPPNPDATSTGLEGARGADVDGIPVHSIRLAGLVAHQEVLFGTQGETLTIRHDSLDRTSFVPGVLLAVRKVSERPGLTVGIEPLLDLT
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_LEPIN
Sequence: MTKEWISLGQLGKPFGIKGWLRLNVRETVLCELKTPISLKLSKPDFHFPEKEITLLEIRPHGGKFIVRFEGVTTPEEAAKWIGGFLFLPQKLLPKIETKNEFYITDLIGLQAIDESGKKLDWKLKDVQDNPAHPILVFVKENGEEILIPFLQVFVGDLDLEKNTIVLIQPEIWNEI
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_PROM2
Sequence: MTEKIISEIILDLVFQCNDFSQFSNKLKDTKSKLIFESIFWEKVFLSWINIILKKKDYELPNYISEKKSFSLGLRIISNQEIASLNKKWMQKNGPTDVLSFPIISDESLNNLDHIELGDIFISLEMALEQSYEYKHTIYREMIWLASHGFLHLLGWEHNNENDLENMLNLQEYLITRLD
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_CVRSD
Sequence: MGRMCIAMAPRTLLLLIGCQLVFGFNEPINIVSHLNDDWFLFGDSRSDCTYVENNGHPKLDWLDLDPKLCNSGKIAAKSGNSLFRSFHFTDFYNYTGEGDQIIFYEGVSFSPSHGFKCLVEGDNNKWMGNKARFYALLYKKMAQYRSLSFVTVPYAYGGNAKPTSICKDKTLTLNNPTFISKESNYVDYYYVSEANFTLQGCDEFIVPLCVFNGHSRGSSSDPANKYYTDSQSYYNIDTGVLYGFNSTLDVGNTAQNPGLDLTCMYLVLTPGNYKAVSLEYLLTIPSKAICLRKPKRFMPVQVVDSRWNSTRQSDNMTAVACQLPYCFFRNTSADYSGDTHDVHHGDFYFRQLLSGLLYNVSCIAQQGAFLYNNVSSIWPVYGYGHCPTAANIGYMAPVCLYDPLPVILLGVLLGIAVLIIVFLILYFMADSSVRLHEA
What is the function of this protein?
Structural protein that makes short spikes at the surface of the virus.  Contains receptor binding and receptor-destroying activities.  Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells.  This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell.  May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one.  May become a target for both the humoral and the cellular branches of the immune system.
What are the official names of this protein?
Hemagglutinin-esterase, HE protein, E3 glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface.
Protein: NPC1_PIG
Sequence: MSARGPAFGLLLLLLCPVQVFSQSCVWYGECGIASGDKRYNCRYSGPPKPLPEDGYDLVQELCPGFFFGNVSLCCDVQQLRTLKDNLQLPLQFLSRCPSCFYNLMNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELEYYVGETFANAMYNACRDVEAPSSNEKALGLLCGREAQACNATNWIEYMFNKDNGQAPFTITPIFSDLPTHGMEPMNNATKGCDESVDEVTGPCSCQDCSIVCGPKPQPPPPPVPWRILGLDAMYVIMWSSYMAFLIVFFGAFFAVWCYRKRYFVSEYTPIDGNIAFSVNSSDKGQAFCCDPLGAAFERGLRRLFAQWGAFCVRHPGCVVFFSLAFIVACSSGLVFIRVTTDPVDLWSAPGSQARREKEYFDTHFGPFFRMEQLIIRATNNQSHIYHPYPAGADVPFGPPLSRDILHQVLDLQTAIENITASYNNETVTLQDICLAPLSPYNKNCTILSVLNYFQNSHSVLDHQVGDFFFVYADYHTHFLYCVRAPASLNDASLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWESEFINFVKNYKNPNLTISFMAERSIEDELNRESNSDLFTILISYAIMFLYISIALGHIKSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYIGVPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGGLSVVPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNRLDVVCCVQGAEDGAGVQASESCLFRFFKNSYAPLLLKDWMRPIVIAVFVGVLSFSIAVLNKVEIGLDQSLSMPDDSYVMDYFQSLSRYLHAGPPVYFVVEEGHNYTSLKGQNMVCGGLGCNNDSLVQQIFTAAQLDNYTRIGFAPSSWIDDYFDWIKPQSSCCRVYNSTDQFCNASVVDPTCIRCRPLTSEGKQRPQGEDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILGNGSGVGATYFMTYHTVLQASADFIDAMQKARLIASNITRTMGLEASSYRVFPYSVFYVFYEQYLTVIDDTIFNLGVSLGAIFLVTVVLMGCELWATVIMCVTIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTLSTKGSRVDRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAIVLLGATHGLIFLPVLLSYIGPSINKAKSLATQERYKGTEREQLLNF
What is the function of this protein?
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment.  Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1.  Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket.  Binds oxysterol with higher affinity than cholesterol (By similarity).  May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).  Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9 (By similarity).
What are the official names of this protein?
NPC intracellular cholesterol transporter 1, Niemann-Pick C1 protein.
What is the protein family that this protein belongs to?
Belongs to the patched family.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Protein: NGF_PONPY
Sequence: MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSTPAAAIAARVAGQTCNITVDPRLFKKRRLRSPRVLFSTQPPPEAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRRA
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.  Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.
What are the official names of this protein?
Beta-nerve growth factor, Beta-NGF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: OBRG_DANRE
Sequence: MAGIKALVALSFSGALGLTFLLLGCALEQFGQYWPMFVLIFYILSPIPNLIARRHADDTESSNACRELAYFLTTGIVVSAYGLPVVLARKAVIQWGAAGLVMAGNCVIFLTILGFFLIFGGGDDFSWEQW
What is the function of this protein?
Involved in protein trafficking.  May be involved in the down-regulation of membrane protein levels (By similarity).
What are the official names of this protein?
Leptin receptor gene-related protein, Endospanin-1, OB-R gene-related protein, OB-RGRP.
What is the protein family that this protein belongs to?
Belongs to the OB-RGRP/VPS55 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Endosome membrane.
Protein: MATRX_IRKV
Sequence: MNIIRKIVKSCKDEEEHKPNPVSAPPDDDDLWLPPPEYVPLAEITGKKNMRNFCINGEVKVCSPNGYSFRILRHILKSFEGVYSGNRRMIGLVKVVIGLAQSGAPVPEGMNWVYKIRRTLVFQWAESSGPLDGEELEYSQEITWDDDSEFVGLQIRVSARQCHIQGRLWCINMNSRACQLWADMSLKTQQSNEDKNTSLLLE
What is the function of this protein?
Plays a major role in assembly and budding of virion.  Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form.  Inhibits viral transcription and stimulates replication.  Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity).
What are the official names of this protein?
Matrix protein, Phosphoprotein M2.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein.
Protein: PSBY_TRIEI
Sequence: MDFDFRLLIVLLPILAAAGWAVFNIGVVAMQQFQKFLNK
What is the function of this protein?
Manganese-binding polypeptide with L-arginine metabolizing enzyme activity.  Component of the core of photosystem II.
What are the official names of this protein?
Photosystem II protein Y.
What is the protein family that this protein belongs to?
Belongs to the PsbY family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: KTHY_RHIME
Sequence: MHADPGIEVSLAKGFFITFEGGEGTGKSTQMRLLAEALSARGYRVLTTREPGGSVGAEAVRHVLLSGAAESFGVRMEAILFAAARSDHVEEVIRPALEQGTIVLCDRFMDSSRVYQGVTGNLEPAFVETLERVAVNGVIPDCTIIFDLPASVGLERARRRAANDSPDRFEKEQLETHEKRREAFLDIAAADPERCRVVDANRPPTAIAAEVLSLVEALLPLEGKPQPSNAEATS
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: PURA_LEGPL
Sequence: MGKNVVVLGTQWGDEGKGKIVDLLTQDAQVVVRYQGGHNAGHTLKINGVKTVLRLIPSGMLRPNVTCYVANGVVLSPQALLSEIKELEGNGINVRERLRISLACPLILPYHIALDKARETHMGKSAIGTTGRGIGPAYEDKVARRALRVGDLFHRDRFANKLTELLDYHNFVLTQYFKQPAVDLESLLDESLQWAEELRPMVCDVSACLHEHRKQGENILFEGAQGVYLDIDHGTYPYVTSSNTCVGSVINGAGFGPRYIDYVLGITKAYTTRVGGGPFPTELLDDVGKRIAERGQEFGAVTGRPRRCGWFDAVLLKRSIELNSISGLCVTKLDVLDGLEVLRIAVAYKDRDGNILSRPPLAADDFNDLLPVYEELPGWQESTADVTVMSDLPANARAYLKRIEEILGIPIDMLSTGPERDSTITLRDPFL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_CROS5
Sequence: MALPKIEEVRQLSDEELAEEIIATKRELFDLRFQQATRQLENTHEFKHTRHRMAQLLTIERERQLNINQSSSTSAEEA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.