PharMolix/UniProtQA huggingface dataset:
Protein: COX2_RAT
Sequence: MAYPFQLGLQDATSPIMEELTNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKYFENWSASMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CMS1_HUMAN
Sequence: MADDLGDEWWENQPTGAGSSPEASDGEGEGDTEVMQQETVPVPVPSEKTKQPKECFLIQPKERKENTTKTRKRRKKKITDVLAKSEPKPGLPEDLQKLMKDYYSSRRLVIELEELNLPDSCFLKANDLTHSLSSYLKEICPKWVKLRKNHSEKKSVLMLIICSSAVRALELIRSMTAFRGDGKVIKLFAKHIKVQAQVKLLEKRVVHLGVGTPGRIKELVKQGGLNLSPLKFLVFDWNWRDQKLRRMMDIPEIRKEVFELLEMGVLSLCKSESLKLGLF
What are the official names of this protein?
Protein CMSS1, Cms1 ribosomal small subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the CMS1 family.
Protein: SYM_PYRNV
Sequence: MAKYVIGSAWPYVQTVPHLGNLIGSVLSADVYARYLRLRGHDVVFVSGSDMHGTPIEVEAIQLGVDPADYAAKMHNIVAELFKRWDISFDLYTHTHSDVHIKFVQDFFLKIYNNGYIFTREEEVPYCPRDRIYLPDRFIIGRCPYCGYERARGDQCENCGRLLDPKQLVEPRCAICGSKPEWRLTRHWYLDLRRLEDRIRRYVEENPHLPPNAKEMSLGMLKEGLKPRAITRDNRWGIPAPFPGAEGKTIYVWFEAVLGYISAVAELKGEEGLRRYWKSPDTKIVFFVGKDNIPFHVIILPALLLANGDGYALPTTTASTEYLLYEGDKFSKSRRWGIWIDEALQLMPPDYWRFVLVYMRPENRDTNFTWQAALEVINKVLNDDVGNYVNRVLTLIKNRMGGAVPPPGTPAKEDEDFVAKATDLFKKAERHYDAIELKDALHAVVEIAREGNRYLNARAPWDLLRRDRESANAVMYRAYWSLKMLAAGLTPVTPRSAEELWRMLGVRQPSWEEAYKPPEAGAPLGEVKPLFRKYTEEEVKNLLKRLEELRSQKAARRYPWEQALL
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPCE_SYNP2
Sequence: MSDWQMAEAWTLEEAIANIQQTEDTGKRYYAAWWFGKFRVQDERAVNALLAALKDETDRSPDGGYPLRRNAAKALGKLGNLAAVQPLIESLESPDYYVRESAAQSLEMLGDRQAIPALQALLAGGVAAAVKAEGKPHLVQPYEAVIEALGTIGATAAIAEIEPFLDHEFAKIRYAALRALYQLTQEAHYAEQLMEALNGNQLQLRRSALLDLGAIGYVPAGQAIAKAYAENSLKLISLKGILESHLQRTAETLDADGLQLLELMDSLL
What is the function of this protein?
Required for the chromophorylation of the cpcA gene product.
What are the official names of this protein?
Phycocyanobilin lyase subunit alpha, Phycocyanin operon protein CpcE.
What is the protein family that this protein belongs to?
Belongs to the CpcE/RpcE/PecE family.
Protein: QUEC_CAMJR
Sequence: MSKKALCIISGGMDSTLCAYLAKKEGYEIIALHFDYEQRTQEKEKECFKQICKALKVEKSYILDVSFIKDIGGNALTDKSIDIPKNELCTSDTPPITYVPFRNGIFLSIAGSLAEKENCESIFIGVVEEDGSGYPDCTDEFIQKAQEFINEGTSKNFKVCIKTPLVRLNKAKIVELALKENVPLELTWSCYESEDEACGECDSCLLRLRGFEKAGFKDKIKYKS
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RABM_DICDI
Sequence: MSKKSLKIITLGDSYVGKTSVFNNFVTGKYEINECTVSPSFYSKTLTIENEPVILNVWDTCSQERFNGLSPIYYRWSNCYTLCFDIHNEKSFKNLDKWMDEARKFCIGKVPFVLIGTKKDIPRTDKSISKERIEQWCKNIEDQGIIDRVHYFETSAKFSQNITESYNAALKLALEHYNKNQKPPITTPAIDSLQEVKPGYCC
What are the official names of this protein?
Ras-related protein RabM.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: SYE_CARHZ
Sequence: MVRVRFAPSPTGPLHIGGARSALFNYLFARKNNGVFIVRIEDTDLERSSRESEKNILESLKWLGITWDEGIEVGGENGPYRQTERLDLYQKYAQKLIEEGFAYYCFCTEEELEEERKNLLAKGEMPRYLGKCRNLTPEQKEKYLAEGRKPTVRFKVPAGRTIVINDLVRGVVSFETDGIGDFIIVKSDGIPTYNFAVVIDDVTMGITHVLRGEEHLSNTPRQILIYEALGFKIPEFAHISLILGKDRTKMSKRHGATSVENYREKGYLPEALVNFLALLGWSPGTEEEIFTMEQLIERFSLDRVAKNPAIFDLDKLNWINGYYIRNSELSRIVELSLPFFQSCGYVSQNPTEEEMRKLTKVVEATREYVVTLSELPEHAAIFYQKELAFEEEAKTLLADEEARNILRKVADKLREIPGSEEEEIKGFLKKLPKELGVGGKKVYMPLRAALTGKTHGPELYQVIAILGPAEAERRIMNLFN
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_METCA
Sequence: MRIMLLGSPGSGKGTQAKYLTERFGIPQISTGDMLRAAVREGTPLGMEAKKIMDAGQLVSDSIILGLIKERIAAPDCANGFLLDGFPRTIVQADALAELGVTLDHVVEIAVDDEEIVRRLSGRRVHPASGRTYHVVFNPPKVEGRDDETGEPLVQREDDKEETIRRRLEIYHVQTKPLVDYYRSKAAQGGVKFHTVPGVGSVEAIRDAVLASLA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_VIBVY
Sequence: MSNAPFLSEVSKRRTFAIISHPDAGKTTITEKVLLFGRAIQTAGTVKGRGSSQHAKSDWMEMEKERGISVTTSVMQFPYNDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEDRTRKLMEVTRLRDTPIVTFMNKLDRDIRDPMELLDEVESELNIACAPVSWPIGCGKEFKGVYHIHRDETILYSTGQGHTIQEQRIIKGLDNPDLDAEVGADLAEQLREELELVLGASHEFDQEMFLKGELTPVFFGTALGNFGVDHMLDGLTDWAPAPLPRQANERAVEATEDKFTGFVFKIQANMDPKHRDRIAFMRIVSGTYTQGMKMNHVRLGKQVNISDAVTFMAGDRSRAEAAYAGDIIGLHNHGTIQIGDTFTQGELLKFSGIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLQNNDLIVGAVGVLQFDVVVARLKSEYNVEAIYESVNVATARWVECGDAKKLDEFQRKNQTNLALDGGDNLTYIAPTMVNLNLAKERFPEVEFRATREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YACG_SINFN
Sequence: MSGEGKKHGSNVEPLRPTRPCPECGRPSVRERYPFCSERCRNVDLNRWLSGSYAIPVADDESKADDEDR
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: AR275_ARTOA
Sequence: MFTSLRFLCFGNTPLPSLNSSRSPQRTPSLGSSSTSSLSPIEEELATPSTPESNDSGLTLSSSIGPYPIPSSLMREVESIRSHILQQKSRHQNQPSRRHKQKNRRQRLQEVAIKQSIASSIREKAKPIATPTCYYDVSSPYAEDTSVFELNPAGEKNTNEEEEFGIASQHDWDEMINPHYNYLGAQEQIWDGDLDSSAYWGLDDLISQGYFETYDNSSVVCHPKQDANTDESYSISKALTISRNVKQPNGDTGWWLVKHVDPRALSKLGSDCVIL
What is the function of this protein?
Regulatory protein; part of the gene cluster that mediates the biosynthesis of sesquiterpenyl epoxy-cyclohexenoids (SECs) such as anthrobotrisins and arthrosporols, metabolites that possess a novel hybrid carbon skeleton consisting of a polyketide-derived epoxycyclohexenol combined with a terpenoid-derived monocyclic sesquiterpenol substructure (PKS-PTS hybrid) (PubMed:33823587).  The SEC pathway plays an important role for fungal soil colonization via decreasing fungal nematode-capturing ability (PubMed:33823587).  AOL_s00215g275 can perform multiple functions in fungal growth and development via regulating the SEC biosynthesis, TCA cycle, and septa formation (PubMed:36547594).  Also involved in inhibiting conidial formation, germination, and nematicidal activity but promotes trap production (PubMed:36547594).  Plays a role in fungal resistances and significantly regulates the fungal morphology and responses to chemical stressors such as cell-wall-perturbing agents (SDS and Congo red), osmotic agents (NaCl and sorbitol), or the oxidant H(2)O(2) (PubMed:36547594).
What are the official names of this protein?
Transcription regulator AOL_s00215g275, Sesquiterpenyl epoxy-cyclohexenoids cluster protein AOL_s00215g275, SECs cluster protein AOL_s00215g275.
Protein: HBOH_PARXL
Sequence: MASVFKVRSASGHVPVVRTLAAMMAVTVVLTACHGGGDNHPPPQANVLPAFITASSVRTQFYDGNTDDLLTAGLGKTGLASATAPAIANAAQPTAAELRRLAIWSNYRALVDMTANGGYGRFWGPNVDLNGNDTLGEGKIAGKEYLAFADDGSGTQNVTVLVQIPASFNPDQPCIVTATSSGSRGVYGAISAAGEWGLKRGCAVAYTDKGSGNGAHELSSSLVTLIDGTLQNATAAGKASLFTANLGNTDLASYNSRFPNRYAFKHAHSQQNPEKDWGRNTLQAIQFAYWALNDSYGTLNGSTRNVRYTSGSITTIAASVSNGGGASLAAAEQDTSGLITAVVVGEPQINLRLPAQVSVAQGGVPVGAFGKPLADYMTLANMLQPCAALAPAAAGAPYLTALPGATTTSIRTARCASLAAAGVIAGADATTQATNALALLHQNGYQTDSDLLQAPMWDSQAVPAVAVTYADAYAKASVTANLCNFSFGTTNAAGTAGVTPAVSPMLTVFGNGNGVPPTNGINLVFNSGAGAADHRLATADGSYAGASCLRTLWTNGTLTGSVDAIRVNANLHGKPAIIVQGRADALVPINHASRPYLGLNQLSEGAASRLSFYEVTNAQHFDAFLGVAGFDSRFVPLHYYNLQALNLMWSHLKNGTPLPPSQVIHTVPRGGTPGAAPALTTANLPPIVASPGINAITAANGAVNVPN
What is the function of this protein?
Participates in the degradation of poly-3-hydroxybutyrate (PHB).  It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.
What are the official names of this protein?
D-(-)-3-hydroxybutyrate oligomer hydrolase, 3HB-oligomer hydrolase, 3HBOH.
What is the protein family that this protein belongs to?
Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family.
What are the subcellular locations of this protein?
Secreted.
Protein: XYLA_ACTP2
Sequence: MSNYFDKIEKVKYEGADSTNPFAFKHYNPNEVILGKTMAEHLRLAVCYWHTFCWTGNDMFGVGSLDRSWQKTGDLLEGAKQKAEIAFEFFQKLGIPYYCFHDVDIAPEGNSYKEYVHNFHTMVDILEKKQAETGVKLLWGTANCFTNPRYMSGASTNPNPEVFSWAASQVFNAMNATKRLGGENYVLWGGREGYETLLNTDLKREREQIGRFMQMVVEHKHKIGFNGTLLIEPKPQEPTKHQYDYDVATVYGFLKQFGLEKEIKVNIEANHATLAGHTFQHEIATAAALDIFGSIDANRGDPQLGWDTDQFPNSVEENTLVMYEILKAGGFTTGGFNFDAKIRRQSTDPYDLFHGHIGAIDVLALSLKRAAKMIEDKTLQGIVDQRYAGWNGDLGQQILAGKASLEDLAKIVESKALDPKPVSGQQEYLENLVNNYIYR
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGRG1_MOUSE
Sequence: MAVQVLRQMVYFLLSLFSLVQGAHSGSPREDFRFCGQRNQTQQSTLHYDQSSEPHIFVWNTEETLTIRAPFLAAPDIPRFFPEPRGLYHFCLYWSRHTGRLHLRYGKHDYLLSSQASRLLCFQKQEQSLKQGAPLIATSVSSWQIPQNTSLPGAPSFIFSFHNAPHKVSHNASVDMCDLKKELQQLSRYLQHPQKAAKRPTAAFISQQLQSLESKLTSVSFLGDTLSFEEDRVNATVWKLPPTAGLEDLHIHSQKEEEQSEVQAYSLLLPRAVFQQTRGRRRDDAKRLLVVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVTNLSDPVVLTFQHQPQPKNVTLQCVFWVEDPASSSTGSWSSAGCETVSRDTQTSCLCNHLTYFAVLMVSSTEVEATHKHYLTLLSYVGCVISALACVFTIAAYLCSRRKSRDYTIKVHMNLLSAVFLLDVSFLLSEPVALTGSEAACRTSAMFLHFSLLACLSWMGLEGYNLYRLVVEVFGTYVPGYLLKLSIVGWGFPVFLVTLVALVDVNNYGPIILAVRRTPERVTYPSMCWIRDSLVSYVTNLGLFSLVFLFNLAMLATMVVQILRLRPHSQNWPHVLTLLGLSLVLGLPWALVFFSFASGTFQLVILYLFSIITSFQGFLIFLWYWSMRFQAQGGPSPLKNNSDSAKLPISSGSTSSSRI
What is the function of this protein?
Receptor involved in cell adhesion and probably in cell-cell interactions.  Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells.  Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (PubMed:21768377).  Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (By similarity).  Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (PubMed:23478665).  Plays a critical role in tumourigenesis (By similarity).  Plays essential role in testis development (PubMed:20981830).
What are the official names of this protein?
Adhesion G-protein coupled receptor G1, G-protein coupled receptor 56, Serpentine receptor cyt28.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [ADGRG1 N-terminal fragment]: Secreted. SUBCELLULAR LOCATION: [ADGRG1 C-terminal fragment]: Membrane raft. Note=Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts.
Protein: DGKI_MOUSE
Sequence: MDAAGRGCHLLPLPAARGPARAPAASSALSPTGLCSGTTSASFAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGADPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQETKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEMYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDIHQVQAADLRRVSAPPGSFTIPQSVPDRLRIRVNKISLQDYEGLHYDKDKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQAVLTGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGDIVKYILDHGPAELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNYKIIGHEDLETAV
What is the function of this protein?
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids.  Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes.  Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (By similarity).  By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway (PubMed:15894621).  May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (PubMed:21119615).
What are the official names of this protein?
Diacylglycerol kinase iota, DAG kinase iota.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Cell projection, axon. Cell projection, dendrite. Presynapse. Postsynapse. Postsynaptic density. Synaptic cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Nucleus. Note=Excluded from inhibitory synapses (By similarity). Localization between cytoplasm and nucleus is regulated by protein kinase C (By similarity). Both in the detergent soluble and particulate fractions (By similarity).
Protein: KUP2_SYNFM
Sequence: MEKQNHSNESSDGHKSSPLFSSTTFLLALGSLGVVYGDIGTSPLYSIRECFHGTHAIALNEPNIFGVLSLVFWSMTMVICVKYVVFVMRADNHGMGGIFALLALIPGDSGRISPRLHGVVAFAATLGASLLYGDGVITPAISVLSAVEGLEVATEAAKPLVVPLTCVVLLALFLVQRRGTGVIGNVFGPIMIVWFVTIAALGAGKIVDRPDILLAVNPVYAFEFFAANRFVGVVVLGSVVLCITGGEALYADMGHFGRNPIRLSWLGLAFPALLLNYFGQGALLLSDPNFAFNPFYGLVPRTLLYPMVCLSTIATVIASQAMISGVFSLTQQAIQLGFCPRMRIIHTSRETRGQVYIPEVNYLLMIACLGLVLVFKKSSGLAGAYGIAVTADMALTSILFFFVITRTWKWSLARAVPLLVLFLFFDLSYFGANLFKIFDGGWITLTIAAIVATSMITWKDGRAALARKILSSRLPENLFLEDVARHNPPRVPGTAIFMSVSPMGIPVSLLHHYKHNQVLHEQVILLSITSTDTPTVPDRKKLHIVDLGQGFYRIIASYGFMETPNIPTIMRLASMQGIVTDPARTSYYLGRESLLTGGDSKMMQWRKALFVYMSRNAGTPTAYFDIPPDRVVELGLQIAI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 2.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GTX3D_NEOIV
Sequence: GWKDWLKTAGGWLKKKGPSILKAVVGAATQ
What is the function of this protein?
Has activity against some Gram-positive bacteria and S. cerevisiae.  Has a non-hemolytic activity.
What are the official names of this protein?
U1-poneritoxin-Ni3d, U1-PONTX-Ni3d, Poneratoxin, Ponericin Pi I4.
What is the protein family that this protein belongs to?
Belongs to the ponericin-G family.
What are the subcellular locations of this protein?
Secreted.
Protein: FPG_RHOOB
Sequence: MPELPEVEVVRRGLERHIVGASIDSVDILHPRAIRRHLPGAADLAGQLTGERIAGADRRGKYLWLVLEPSTVALVVHLGMSGQMLVQPPELPTEKHLRIRARLDSGLDLRFVDQRTFGGWALAPLVEVDGSLVPDSVAHIARDPLDSRFDLAATVKVVRGKHSEIKRVLLDQTVVSGIGNIYADEALWRAQIHGNRLTDRLTGPRIGAVLTAAQQVMREALSQGGTSFDALYVNVNGESGYFDRSLSAYGQEDRPCPRCGTAIRREKFMNRSSFSCPKCQRAPRRSPAR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: STAR_HUMAN
Sequence: MLLATFKLCAGSSYRHMRNMKGLRQQAVMAISQELNRRALGGPTPSTWINQVRRRSSLLGSRLEETLYSDQELAYLQQGEEAMQKALGILSNQEGWKKESQQDNGDKVMSKVVPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELAAEAAGNLVGPRDFVSVRCAKRRGSTCVLAGMATDFGNMPEQKGVIRAEHGPTCMVLHPLAGSPSKTKLTWLLSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLESHPASEARC
What is the function of this protein?
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone.  Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
What are the official names of this protein?
Steroidogenic acute regulatory protein, mitochondrial, StAR, START domain-containing protein 1, StARD1.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CCA_SULIN
Sequence: MIEEEVLKIIKPTEEDKKGIEKVLEIIRERLNKLDFEVEGSFRKGTWLRQDTDIDVFVFYPKDVGKEYLERNALNDIINRIKDLDYTLAYAEHPYVIVNINNVEVDIVPALRVESGDKAITAVDRTPFHTKYVTSHLDERGKDEVRLLKRFMKGIGVYGAELKVQGFSGYATELLIIYYGNFRKVLEEASKWKHPIKIELTKPMKIFSEPLIIPDPVDPKRNVTAAVSLKNIATFSIAAKYYLKNPSIEFFFPSKKVEEKVKGDVLILRLNLDEKSSEDIVWGQIKRSVNKIERALKQYGFRVIDVQAWGDTNNITIAVQLESKNIGQYYLNIGPQYYSETIEDFIQKNDNIWVGEDGRLYSIKERKEYDAETIAKKNIVLKVKYNIESYWLQNKEDQQIMKFLRKTPTWLK
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
Protein: RS13_BURA4
Sequence: MARIAGVNIPNHQHTEIGLTAIFGIGRTRSRSICSAAGVEFSKKVKDLTDADLEKLREEVGKFIVEGDLRREVTMNIKRLMDLGCYRGVRHRKGLPMRGQRTRTNARTRKGPRRAAQALKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: PYRDA_STRPG
Sequence: MVSTATQIGHFSFDNCLMNAAGVYCMTKEELIEVEKSQAASFVTKTGTLEVRPGNPEPRYADTRLGSINSMGLPNNGFRYYLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAIMASDYEGLVELNLSCPNVPGKPQIAYDFETTNQLLENLFTYYTKPLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKPSIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSLNDFRGNLRYKD
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
What are the official names of this protein?
Putative dihydroorotate dehydrogenase A (fumarate), DHOD A, DHODase A, DHOdehase A.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.