PharMolix/UniProtQA huggingface dataset:
Protein: D5_FOWPN
Sequence: MALSVIRNNHIIFVLKQIGVRTKHRENNNSKYVESFTCDELERYIYSNPDCTLFETLKDEEYYSNVRVFFDVDMDGRLDDKYQATHNFVNIITKFVADYAYNDCKMISNHRDKDKMITDMKSNFSITESTDKEKTSFHLIFFNCYTTLDTLINMRKKLIVLTKESNNRLVKAIDTSVYRHKPSLRIVGTKKDSINIHVHKKTKQNIHFKNYLFTYVDYNEEDCYYFVSEQQHQSPDLLNWKEEYIPFHDAIKKISKAIGNSIINLKDITAENFTVTPLDIYYATPCNLCKKVSHKHPHHLLISNDCIRIYKSGNPNSCKIKTISLEGNKLFSISQQIIDLNVINVSDRGEYLVWLKNVWRMCEDDNNITKLILYMRDHLSSDCTDLLLCPRNRKVIEHNLKDMLIDTIETDTYPEKLQFLNGVYDIKDSIFYQGNDAKKFVCTVSTGYKYEEGINVDDITTELMSILDDIQPKTKENFENRELYEQILSSCLMGTTKQCIFFFYGETATGKSTTKKLLKSVMHNMFLETGQVILTEQMDKGPNPFIANMHLKRVVFCSELPDFSCNTSKKIRSDNIKKLTEPCVVGRSCYSNKINNRNHATIIIDTNYKPVFDKVDNAIMRRIALVNFKTHFTNTKKKVHNSKYDFIKPLNESLDSKIQSNYFRYAFLKILLGWFSKYHVPNLRILPTPDKIPDFKFRLKVESLIIPSNSTHVKYVDKLMKLGYITDDDGIPVLQLNIFQQKLSLHFNVKLYGQDIDSFIMKNKKYMNLADEYMSFIFIEDLNTINEPRNT
What is the function of this protein?
Primase which may have roles in initiation of DNA replication or lagging-strand synthesis.
What are the official names of this protein?
Primase D5.
What is the protein family that this protein belongs to?
Belongs to the poxviridae D5 family.
Protein: CASQ1_PELLE
Sequence: MKGPWLVLAALCLSLANLGPRGEDGLDFPEYDGEDRVIHISLKNYKAALKKYEVLALLYHEPIGDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEDDAAVAKKLGLDEEDSIYVFKDDEMIEYDGEFSADTLVEFLLDVLEDPVEFIDGSHELAAFENLDDEPKLIGYFKNEDSEHYKAYEDAAEEFHPYIPFFATFDAKVAKTLTLKLNEIDYYEPFHDEPITIPSKPNSEKEIVDFLHQHKRPTLRKLRPDSMYETWEDDLNGIHIVAFAEEDDPDGYEFLQIIKEVAEDNTDNPDLSIIWIDPEDFPLLIPYWEEKFGIDLSRPHIGVVNVTDADSVWMDMDDEEDLPTVDELEDWIEDVLEGEVNTEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
What is the function of this protein?
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:1375450).  Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits.  Can bind around 80 Ca(2+) ions.  Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.  Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity).
What are the official names of this protein?
Calsequestrin-1, Calsequestrin, skeletal muscle isoform.
What is the protein family that this protein belongs to?
Belongs to the calsequestrin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells. In a minority of cells, homogeneously detected in the ER lumen. Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium.
Protein: SDHB_ASHGO
Sequence: MVFRAGIGRIGLIRGLATQAAEVSATRYKSFKIYRWNPDTPAEKPRMQEYKVDLNKCGPMVLDALIKIKNEQDPTLTFRRSCREGICGSCAMNIGGRNTLACLCKIDQAENKDVKIYPLPHMYVVKDLVPDLTNFYKQYKSIQPYLQKASKPADGREHLQSIADRKKLDGLYECILCACCSTACPSYWWNNEQYLGPAVLMQAYRWMVDSRDGAGAGRREQLQNAMSVYRCHTIMNCTRTCPKGLNPGKAIAEIKKALAFA
What is the function of this protein?
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Iron-sulfur subunit of complex II, Ip.
What is the protein family that this protein belongs to?
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: HIS1_POLNA
Sequence: MITLALSKGRIFDDILPLLRTAGIEVLDDPEKSRKLILGTNQPDLRVVLVRATDVPTYVQYGGADIGVVGKDTLLESGSQGLYQPLDLQIAKCRISVAVRQGFDYAAAVKQGSRLKVATKYVAISRDFFATKGVHVDLIKLYGSMELAPLTGLADAIVDLVSTGSTLKANHLIEVERIMDISSHLVVNQTALKLKQAPIRKLIDAFSLACAQAAAKQ
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUM6_CAEBR
Sequence: MVLVSKGDFIWIEPGKAEGSIPIGARVIDQDHGRLKVIDDLGNEQWLSADRRVRLMHPTSVQGVEDMCQLGDFHESAILRNLFIRYREKLIYAYTGSILIAVNPYMDIAIYTADEIRMYKRKRIGELPPHIFAIADNAYTNMRREKKNQSVIISGESGAGKTESTKLVLQFLATISGQHSWIEQQVLEANPVLEAFGNAKTIRNDNSSRFGKYIDVHFNESGSIEGAKIEQYLLEKSRIVTQSENERNYHIFYCLLAGLSKEEKMELELGTAADYYYLIQGKTLTAEGRDDAADLAEIRSAMRVLMINEQEIGSIFKLLAALLHIGNIRFRQNTTDNMESVDVADPSTLVRIAKLLNLHEQNLLDAITTKSLVTREERVISRLNGQQAIDARDALAKAIYGKLFIHIVRRVNDAIYKPSQSIRTSIGILDIFGFENFESNSFEQLCINFANETLQQFFVQHVFKMEQKEYDEENINWRHIKFVDNQATVDLIAQRPMNILSLIDEESIFPKGTDKTMLLKLHSTHGRNELYLQPKSELQRAFGVTHFAGSVFYNTRGFLEKNRDSFSGDLSALISSSKMPFLARLFDDLEYDTSSRKKVTVGNQFRRSLEQLMTQLTQTHPFFIRCIKPNELKRALVMDRDLVLRQLRYSGMMETIKIRRSGYPIRHDYYPFVFRYRVLVSSIRGPANRIDLHDAAKKICHKVLGPNADYQLGKTKVFLKDKHDLVLEQEYYRILKDKAVIIQKNVRRWLVRKDFEKQRQAAVTIQTAWRGYDQRKRYRQIISGFSRLQAVLRSRQLVSHYQSLRKTIIQFQAVCRGTLLRRQVGEMRRRGEKAPLTEVSSTASVISDSHEEELVSHLFDFLPSDGKDSGNENDSTDSSRRGSYSRLHPSPVMPPTNIPRVDSFIDEDLSKFQFGKYAATFFQAQATATHIKKPIKTALLTHTEPSAQLAALASWTTILRFMGDLSDVKPGSTNGSEIYDKTPVMSRLYATLGKKFSTRDVEEALLSSEYGGNKTLKKGMGKKLISMTLKRKGKIGGSDTSSISSDSAYSGFNAMLENKPMTSLDKLHYIIGLGILREDLRDEIYCQLCKQLSNNPSKLSAARGWILLSLCVGCFAPSERFIKYLFCFIRERGPAGTGYSTYIEDRLRRTQVNGTRHQPPSYVELQANKSQKPVVLAVTFMDGSVKTLCADSATTASELCKQLAEKVGLTNSFGFSLYIALFDKVSSLGSGTDHVMDAISQCEQYAKEQGRQERNAPWRLFFRKEIFSPWHDPKDDAVSTNLIYQQVIRGIKYGEYRCDKDEELAAICAQQYYIDEGTMDVNKLENNLASYLPDFEMAGKDMALEKWTQTIMHQYRKKFTGRLPSQIEVKEDVVSIAKTKWPLLFSRFYEALKFAGPPLPKNEVIIAVNWTGVYVVDDREHVMLEFSFPEISTAYYGKGKRSTTDTCTIRSVVGDEYTFQSPNADDITNLIVLFLEGLKKRSRYLVAIKAQKGDEKNNFLDFEKGDLLILVNEFTGNTLLTESVVKGENSRTCLFGLIRAENVYVLPTLVKPSKNTLQIFPKDMDMSLDLFNNNKQVTVIDYNAEPYTLENFAEDNFNSQVKRVGSQISLMTLRKKESQIESWRFSRDHIEHPLLKKLNGRDDACRGAVEIFAAIMKYMGDEPSKRSRLGTHLTDHIFKLPISMEALRDELYCQLVKQLTLNPSIMSEEKGWELLWMATGLFAPSAALAKEISHFLKSRPHPIALDCQNRMQKLAKGGSRKYPPHLVEVEAIQHKTTQIFHKVFFPDKTDEAIEVDSATRARDFCHKIGYRLGLKSSDGFSLFVKIKDKVLAVPETEFFFDYVRSLSDWVHTNHAMQKDSTMIPINYQVYFMRKLWFNFVPGADSQADIIFHYHQESQKYLLGYHKTTKNDVIELAALILRAMTKEGKNAPLAQIPQLLDDIVPKDSLKMCSASEWRKTISNAYARVEHLKPDQAKIEFLKYICRWPTFGSAFFPVSQYSDLSLPDRLLLAINQTGVNIYHLESKNLLVQYPFNVICNWTSGNTYFNMTVGNMLKGNEGKKLLLDTTVGYKMDDLLTSYISLLISNQTNQPSKHREVAL
What is the function of this protein?
Myosins are actin-based motor molecules with ATPase activity.  Unconventional myosins serve in intracellular movements.  Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
What are the official names of this protein?
Unconventional myosin heavy chain 6.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUD_ECOUT
Sequence: MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAEETELQTLLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIHFWLPAGSFATSVVRELINTTGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: SYA_BLOFL
Sequence: MYKSIDVVRQEFLDFFHKQEHQVVPSSSLVPKNDQTLLFTNSGMNQFKDIFLGLVKPSYKRVVTAQRCMRAGGKHNDLNNVGYTECHLTFFEMLGNFSFGDYFKDDAIQFAWELLTDSNWFGLSKDKIWVTTHIEDDESYNIWVKQVGISTKRIVKIGNKNSDLYDSDNFWQMGNIGPCGPCSEIFYDFGSDLKGKPPGYMQGLGSRYIEIWNLVFMQFNRQLNDRLIDLPMLSVDTGMGLERITAILQGVHSNYLIDVFKNLIVDISNIMKVKEYINNRSLYVIADHIRACVFLIKDGVVPSNEGQGYVLRRIIRRSVRHGRKLGVNDIFLYKLVNLVIVHMNYVSNILYDQKDLIEQILFNEEKLFNNTLKKGLELLEKSLKNLNQDKILSGEIAFQLYTTYGFPLELTKDICCERNIKVDQLEFDQIMLTERRNSKRLSQFHKNFNNIILSSYAKTSTFVGYKCFSCQSKIIALLQDNELINKMCDVDQESMVILDITPFYGESGGQIGDSGYLKGECGVFKVKNTKKYGQIIVHIGVLISGIFLIGEQVFAQVNRLKRKDISVNHSSTHLLHSALLKILGSHVTQQGSLINDKYFRFDFSHYNAITITQINEVENLINQQIWDNLLVTENIMLMESARNIGAIMLLHKQYTEKVRVIQIGDCSIELCGGTHVSNTNEIGLFIITKEFGIGSGVRRIEAVTKNAALSVIQNKKKLIQNIAQIAQSDDVNLLNVIHEFKARYEKLDREIKLLNSKQEIQKVLSLVREVYYIKNVRVLVNHVKNMESSSLFKMVKLLKHYLQSGIVVLINIRKNNIAHIVISITKDLVECNRIYAIDLIQYIIRSVKNGKGGGRFDFAQLNINNVKNVSELVIQIQSLLNDIICNIKSIK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDA2_CRYNB
Sequence: MIPSTAAAALLTLTAGVALAHPGCGGQEIGRRNVGGPMVYRRDVTDEASAAASTDVNTECTAYGYAPVTEIASSFPTIWETASILSNDTEGQQLFATINSTLNTKLPNDVPHGTPTGDWTGVNYNSSDPDCWWTHNKCTTPASDTGLEADITIVPEPMTWGLGFDDGPNCSHNALYNLLSENNQKATMFFIGSNVMDWPLQAMRAHDEGHQICVHTWSHQYMTALSNEVVFAELYYTQKAIKAVLGVTPQCWRPPYGDVDNRVRMIAQALNLTTIIWSDDTDDWAAGTDGVTEQDVTDNYQAVIDKAGNGTYTTHGPVVLNHELTNYTMSVFMTMFPKIKSAFSYIVPMCTAYNITQPYLESNVTCPNFETYISGVTNISSSTTQKDGSSSTNTSSSGSGSAAGSASATSSSDDSSSSGSASASSSSSNASSGALGMFDGLSGVGLVLSGVVAGVMLL
What is the function of this protein?
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate (By similarity).  Chitosan is required to anchor melanin to the cell wall, for maintenance of cell wall integrity, and for cytokinesis (By similarity).
What are the official names of this protein?
Chitin deacetylase 2.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall. Cell membrane; Lipid-anchor, GPI-anchor. Note=GPI-anchored cell membrane protein (GPI-PMP) (By similarity). Non- covalently associated to the cell wall by means independent of both its GPI-anchor and beta-1,6-glucan (By similarity). Cell membrane localization is critical for effective deacetylase activity (By similarity).
Protein: SYD_PORGI
Sequence: MYRTNTCGELRLSHLQQTVTLCGWVQRVRRMGGMTFVDLRDRYGTTQLVFNRDSAPAELCDRAEDLGREWVIRATGTVMERSSKNPNIPTGDIEIAVGEMDVLNRSEVPPFTIEDETDGGDDLRMKYRYLDLRRHCVRSNMELRHRMALEVRKYLDGEGFLEVETPMLIKSTPEGARDFVVPSRMNPGQFYALPQSPQTFKQLLMVSGFDRYFQIVKCFRDEDLRADRQPEFTQIDCEMSFVEQEDVLSTFEGMAKHLFRTIRHVEISEAFPRMTWHDAMKYYGSDKPDTRFDMRFVELMDVLKGHGFSVFDSAAYIGGICAKGAGSYTRKQLDALTDFVKRPQVGAKGMVYARVESDGSVKSSVDKFYTQETLQELRRTMEAEPGDLILILSGDDLMKTRKQLCELRLEVGSQLGLRDKNKFSCLWVVDFPLFEWDEETKRFYAMHHPFTSPKPEDIPLLDTDPGAVRANAYDMVINGVEVGGGSIRIHDSALQQKMFELLGFTPEKAQEQFGFLMNAFKYGAPPHGGLAYGLDRWVSLFAGLDSIRDCIAFPKNNAGRDVMIDAPSVIDEAQLQELFLELIPNEN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDUJ_SALTY
Sequence: MNNALGLVETKGLVGAIEAADAMVKSANVQLVGYEKIGSGLVTVMVRGDVGAVKAAVDAGSAAASVVGEVKSCHVIPRPHSDVEAILPKSA
What is the function of this protein?
The 1,2-propanediol (1,2-PD) degradation bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
What are the official names of this protein?
Bacterial microcompartment shell protein PduJ, Bacterial microcompartment protein homohexamer, BMC-H, Propanediol utilization protein PduJ.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: HEM6_BURP0
Sequence: MTDSTYDVNRVRAYLQGLQMRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGGFFERAGIGFSDVAGDALPPSASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALEPFGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYLPIVERRRDTPYGERERAFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEFLVPRDWA
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAED_ECOLX
Sequence: MKKYVTTKSVQPVAFRLTTLSLVMSAVLGSASVIAGEKLDMSFIQGGGGVNPEVWAALNGSYAPGRYLVDLSLNGKEAGKQILDVTPQDSNELCLTEAWLTKAGVYVSADYFREGYDATRQCYVLTKAPSVKVDFDVSTQSLALSIPQKGLVKMPENVDWDYGTSAFRVNYNANANTGRNNTSAFGSADLKANIGHWVVSSSATASGGDSGDNSTTINMFTATRAIRALSADLAVGKTSTGDSLLGSTGTYGVSLSRNNSMKPGNLGYTPVFSGIANGPSRVTLTQNGRLLHSEMVPAGPFSITDVPLYTSGDVTMKITGEDGRDEVQNFPLSVMAGQLSPGQHEFSVAAGLPDDDSDLKGGVFAASYGYGLDGLTLRAGGVFNQDWQGASAGVVAGLGYLGAVSADGAYATAKYRDGSHSGNKVQLSWSKQLETTNTGLRVSWSRQSEEYEGMSSFDPTELWSQSNHGRRTKDEWNAGISQPVGGLFSLSVSGWQRSYYPASMTGSYRYSDDNGKETGITGSLSTQIKGVSLNLGWSGSRNSRGENNWSASASVSVPFTLFDRRYSSSASVSTSKGGGTGFSTGVSGSLNDRFSYGLGGGRDGDGGTSSYLNASYSGDRAYLNGVLNHSQSGGTSGSVSVSGSVLAVPAAKDIMFSRTTGDTVAVVNVKDTPGVKVTSGDGQTDSDGNLVVPLNSYDWNTVTIDTGTLPLSTELTNTSQKVVPTDKAVVWMPFDALKVKRYLLQVKQRDGEFVPGGTWARDSKNTPLGFVANNGVLMINTVDAPGDITLGQCRIPAARLQDTEKLQEITCE
What is the function of this protein?
Involved in the export and assembly of K88ab fimbrial subunits across the outer membrane.
What are the official names of this protein?
Outer membrane usher protein FaeD.
What is the protein family that this protein belongs to?
Belongs to the fimbrial export usher family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: VE6_HPV54
Sequence: MSATEPHTDQPRTLADLCKVCNIPMHSLQLPCAFCKKTVCTAEIYAFQYKDLFVVWRHGFPHAACALCLELHGQINYRRHRDRACLWETVEQECGKPLEEIFIRCWLCHKPLCNVEKQRHVDYNRRFHCVRGYWKGRCLHCWKP
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation.  In turn, apoptosis induced by DNA damage is inhibited.  E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: DDL_ALCBS
Sequence: MDKRALKERLSRVGRVAVLAGGRSAERAVSLKSGAAVHAGLRNLGLLAELVDPADKSVDTLRGFDAAFIALHGRGGEDGVIQGVLEHLEIPYTGSGVMASAIGMDKVRTKQLWKGAGLPTPAFYVAGREEAELGFPVIVKPAHEGSSIGMAKADNTEELGEALVAAEKFDQDVLVEAWVNGPEYTVAVLGDEALPAIRLQTPHVFYDFEAKYQSDSTEYLCPAGLDDADEQALRTLALTAFRVAGCRGWGRVDVMRDEQGQWQLLEVNTVPGMTDHSLVPMAAKATGRDFDVLVGEILLDALERGRG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_BEII9
Sequence: MDQFKPFIAKLATGSSLTRAEAEAAFDQIFAGEVTPAQLGGFLMAMRVRGETVDEIIGAVTAMRARMVRVDAPTDAIDIVGTGGDGHGTFNVSTLASLIVAACGVPVAKHGNRAASSRSGASDVLSALGVRTGLDSAGVEACIRGAGIGFMMAQTHHTAMRHVASARVELGTRTIFNLLGPLCNPAGVTRQLLGVFSQAWLEPLAQVLQALGGKHVWVVHGSDGLDELTTTGPSFVTALEDGAIRSFTITPEMAGLPQATLADLKGGDPETNAAALREALGGKKSAYRDIALLNAAAALVIAAKAKDLKEGVLIGAKAVDSGAASAVLAKLVALSNQDNRAA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RS19_AZOVD
Sequence: MPRSLKKGPFIDLHLLKKVEVAVEKNDRKPVKTWSRRSMILPQMVGLTIAVHNGRQHVPVLISEDMVGHKLGEFAATRTYRGHAADKKAKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: HSLV_DESHD
Sequence: MFHATTIVAVKKGDQVAMAGDGQVTMGQATVMKHKARKVRRLFHGKVLAGFAGSVADAFTLFEKFENKLEEYQGNLQRAAVELAKDWRMDKALRNLEALLIVADKQSMLLISGSGEVIEPDDGIAAIGSGGNYALAAARALVKNTDLQPAQLVQEAMEVASSICVYTNDQIIVEEL
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_BARBK
Sequence: MAISYNHSMSACQKIKTDQAMVRDRLKQSQSLIGLSHDEMVQALRSIGVPEHQTRMRVRQLWHWFYVRGVSSFDEMFNISKPMREMLKDNFSIAYPEIVEEQISKDGTYKWLLRFPARGAGKPVEIETVYIPGEGRGTLCVSSQVGCTLTCSFCYTGTQKLVRNLTAEEILLQLLFARNRLGDFPGKDKPDHSSLSEERRKITNIVMMGMGEPLYNFEAVKKALLIASDGDGLSLSKRRITLSTSGVVPEIIRAGEEIGVMLAVSLHAVCDSLRDVLVPINKKYPLSMLMEACRNYPGLSNAKRITFEYVMLKDVNDSLDDAKKLIKLLKGIPAKINLIPFNPWPGSHYECSDWEQIERFADVINRAGYASPIRMPRGRDILAACGNLKSTSERLRKSERLQLESMMGDDLSSI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_HERAR
Sequence: MDKIRKSDEVIVLTGKDKGKRGVVQRRVDANYLVVEGVNVAKKATKPNPMTGATGGIVDKLMPIHVSNVALFNAATGKADRAGFKDVDGKKVRVYKSSGEAVKV
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: DPCKG_METM5
Sequence: MYLLNDKVAHELKKPFGKVYKELPSIEGKVVSIGDVTTKHLLSNGIIPNLSILDFKTKRNIPVNIPHKFKTIFEVENPQGCISDEAIERIKYLSTIHDRDMALIIKGEEDLLTIPVIKYFPEDTSVIYGQPDEGMVLLKITDELKQKIEKLLKDMEER
What is the function of this protein?
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
What are the official names of this protein?
GTP-dependent dephospho-CoA kinase, Dephospho-coenzyme A kinase, DPCK.
What is the protein family that this protein belongs to?
Belongs to the GTP-dependent DPCK family.
Protein: SYM_HERAR
Sequence: MSNPLPRKLFVTTALPYANGAFHIGHIMEYIQADIWVRFQRMQGNQVDFVGADDAHGAPIMIAAEKAGLTPQQFVSNIAAGRKQYLDGFHIAFDNWSSTDSPENHQLAQQIYLDLKKAGLIASKTVEQFFDPEKNMFLPDRYIKGECPKCHTKDQYGDNCEVCAAVYSPTDLINPYSALTGATPVLKHSEHFFFTLSDPRCVAFLEEWVSGLDTDGKTHLQAEVANKVKEWFSARTNPDGTISEGLNDWDISRDAPYFGIEIPDAPGKYFYVWLDAPVGYLASLKNLLDKRGENFDAYMAEPALEQIHFIGKDIVNFHTLFWPAMLKFSGRKTPNKVFVHGFLTVNNGEKMSKSRGTGLDPLKYLSLGMNPEWLRYYLANKLSARNEDIDFNPEDFIARVNSDLIGKYVNIASRAAGFIAKKFDGRVVSDWATADDVFISKLRNVASEIQALYDQREYGKALRTIMEQADAINAYVDANKPWELAKKPENSAALQEVCSRLLEAFRILTIYLKPVLPELAKQVEALLNIAPLQWSDVGTPLPHNHQVNPYSHLMTRVEPKMLDALFDMPAVVDVTVNVPNGTSETEVAADSTIEAIAPEIKIDDFAKIDLRIAKIVNCEHVEGSDKLLRLTLDMGEGRLRNVFSGIKSAYQPEDLIGKLTVMVANLAPRKMKFGISEGMVLAASAADEKSNPGIYILNPWPGAEPGMRVG
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK2_OENAR
Sequence: MAIHLYKTSTPSTRNGAVDSQVKSNTRKNLIYGQPRCSKGRNARGIITAGHRGGGHKRLYRKIDFRRNERDIYGRIVSIEYDPNRNASICLIHYGDGEKRYILHPRGAIIGDTIVSGTEVPIKMGNALPLKMPLGTALHNIEITLGKGGQLARAAGAVAKLIAKEGKSATLKLPSGEVRLISNNCSATVGQVGNVGVNQKSLGRAGSKRWLGKRPVVRGVVMNPVDHPHGGGEGRAPIGRKKPATPWGYPALGRRSRKRNKYSENLILRRRSK
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRMFO_DESRM
Sequence: MTEHRVTVIGAGLAGSEAAWQLARRGIHVDLYEMRPQKYPPAHHTAYFSELVCSNSLRAAAIENAVGLLKEEMRQLDSLIISAADNHKVPAGGALAVDREGFSRYITETLEDHPLIDIHREEVTKIPEKGIVIVASGPLTSESLSHEIAKVTGEQYLYFYDAAAPIVTLESLDMTKVFRASRYGKGEEAYLNCPMDQDEYEKFYDALIHAERAPIKEFEKQVHFEGCMPVEVLASRGKDTLLYGPLKPVGLTDPRTGKRPHGVVQLRQDNAEGTLFNLVGFQTNLKWGEQKRVFSFIPGLEDAEFVRYGVMHRNTYITSPVLLQPTLQMKEHPRIFFAGQITGVEGYVESAAAGLIAGINAAALAKQKDLLIFPKETAHGALMHYITTASTKNFQPMNVTFGLFPELTVRLKGKRERGRAQAERALEILKEWIEKEKICDI
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2629_MYCBO
Sequence: MPLHQLAIAPVDVSGALLGLVLNAPAPRPLATHRLAHTDGSALQLGVLGASHVVTVEGRFCEEVSCVARSRGGDLPESTHAPGYHLQSHTETHDEAAFRRLARHLRERCTRATGWLGGVFPGDDAALTALAAEPDGTGWRWRTWHLYPSASGGTVVHTTSRWRP
What are the official names of this protein?
Uncharacterized protein Mb2629.