PharMolix/UniProtQA huggingface dataset:
Protein: TAX_HTL32
Sequence: MAHFPGFGQSLLYGYPVYVFGDCVQADWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVVSSALQYLIPRLPSFPTQRTTRTLKVLTPPTTAATPKIPPSFFHAVKKHTPFRNNCLELTLGEQLPAMSFPDPGLRPQNIYTMWGSSVVCLYLYQLSPPMTWPLIPHVIFCHPEQLGAFLTRVPTKRLEELLYKIFLSTGAIIILPENCFPTTLFQPTRAPAVQAPWHTGLLPCQKEIATPGLIWTFTDGSPMISGPCPKEGQPSLVVQSSTFIFQQFQTKASHPAFLLSHKLIHYSSFHSLHLLFEEYTTIPFSLLFNEKGANVDDDEPRDGSQPPARGQIAESPV
What is the function of this protein?
Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways.  Binds to two 21 bp repeat elements located within the LTRs, referred to as Tax-responsive element (TRE).  Binding to TRE requires the interaction with CREB1 and CREBBP.  Activation of NF-kappa-B leads to up-regulation of the expression of gene promoters containing NFkB motifs like IL8 or BCL2L1.  Inhibits the action of p53/TP53 and MYCB.  All these functions could lead to the possible occurrence of lymphoproliferative disorders.  Required for viral replication (By similarity).
What are the official names of this protein?
Protein Tax-3, Trans-activating transcriptional regulatory protein of HTLV-3.
What is the protein family that this protein belongs to?
Belongs to the deltaretrovirus Tax protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Shuttles from the nucleus to the cytoplasm. Found predominantly in the nucleus (By similarity).
Protein: YOKA_BACSU
Sequence: MELKNIVNSYNITNILGYLRRSRQDMEREKRTGEDTLTEQKELMNKILTAIEIPYELKMEIGSGESIDGRPVFKECLKDLEEGKYQAIAVKEITRLSRGSYSDAGQIVNLLQSKRLIIITPYKVYDPRNPVDMRQIRFELFMAREEFEMTRERMTGAKYTYAAQGKWISGLAPYGYQLNKKTSKLDPVEDEAKVVQLIFNIFLNGLNGKDYSYTAIASHLTNLQIPTPSGKKRWNQYTIKAILQNEVYIGTVKYKVREKTKDGKRTIRPEKEQIVVQDAHAPIIDKEQFQQSQVKIANKVPLLPNKDEFELSELAGVCTCSKCGEPLSKYESKRIRKNKDGTESVYHVKSLTCKKNKCTYVRYNDVENAILDYLSSLNDLNDSTLTKHINSMLSKYEDDNSNMKTKKQMSEHLSQKEKELKNKENFIFDKYESGIYSDELFLKRKAALDEEFKELQNAKNELNGLQDTQSEIDSNTVRNNINKIIDQYHIESSSEKKNELLRMVLKDVIVNMTQKRKGPIPAQFEITPILRFNFIFDLTATNSFH
What are the official names of this protein?
Resolvase homolog YokA.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the site-specific recombinase resolvase family.
Protein: RBFA_NEIMF
Sequence: MRKPQRGYARQDRVKEQIMRELAELVRTGLKDPRAGFITVNEVEVTRDYSHATVFYTILNQDAREITEEVLEHARGHLRSELAKRIKLFKTPELHFKYDESLERGLNLSALIDQVAAEKPVED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_BURMA
Sequence: MRILLSNDDGYLAPGLAALYEALRPLAEILVMAPEQNCSGASNSLTLSRPLSVSRSAATGFYYVNGTPTDSVHVALTGMLDTKPDLVVSGINNGQNMGDDTLYSGTVAAATEGIMFGVPAIAFSLVHKEWAHLGDAARVAAEIVRHYLDHPLPGQPLLNVNIPNLPYEELKGWRVTRLGKRHPSQPVIRQTNPRGEPIYWIGAAGDALDASEGTDFHATASGYVSITPLQLDLTHTQMLGATRDWARAGSGAS
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCOA7_MOUSE
Sequence: MDTKEEKKEQKERKQSYFARLKKKKQAKQNAEIVSAASSKSRSGKDDANSDILEQDKFNVTAEGDHSTDDKKKRKSNQLKEIRRTELKRYYSVDDNQNKTHDKKEKKMMVQKPQGTMEYTAGSQDTLNSVALKFNVTPNKLVELNKLFTHTIVPGQVLFVPDANISSSTIQLSSSTPGATVSPSSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVVSIALYSDISHMKIKDALPSDLPRDLCPLYRPGEWEDLASEKDINPFSKFKSINKEKRQQNGERTLALDAKSVRSPEESTERTCTRIEPPDNSELWKLKNLQSSRGTTSESPSVTQLSMRAALEPTAKENCLLKGDEDFVDLEELSSQPESGINKGDATKECLSYDQKKDGPHTVMSAKKGHVQSAQEVMGPESDTELKGALDLETAEKQDEAPEVDKHSGSPENLGESTLNIHEDLDKIKLIEFYLNKNKEGSQLLENVQKSELSDRKSIEPGGIDITLSSSLPQAGDSPPEDNKEPGTLWVKGGETLPLKLDPSAEETVINNKEVLDSLGSSLDKMCHSAQMDNKSEIQLWLLKRIQVPIEDILPSKEEKSKTPPMFLCIKVGKPMRKSFASHTATMVQQYSKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGKDAKEQGFVVVEKEELNMIDNFFSEPTTKSWEIITVEEAKRRKSTCSYYEEEEEEEEGLPILQPHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYGTGETFLYTFSPNFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFIVQDLEVWTFE
What is the function of this protein?
Enhances the transcriptional activities of several nuclear receptors.  Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA (By similarity).
What are the official names of this protein?
Nuclear receptor coactivator 7.
What is the protein family that this protein belongs to?
Belongs to the OXR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL32_SULAC
Sequence: MTKPAKKNMKSPGKAIKFLRFDWDKYYRIGRQERWRKPRGIDNAIRLELKGYQPKVKIGYRTDKQIRGLHPSGLRPILVKSVKDLEAFAKGKQDVIIIISSTIGLRKRIELIKKAEELGLKIANR
What are the official names of this protein?
50S ribosomal protein L32e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
Protein: KCY_STRP1
Sequence: MKAIKIAIDGPASSGKSTVAKIIAKNLGYTYLDTGAMYRSATYIALTHGYTGKEVALILEELEKNPIFFKKAKDGSQLVFLGDEDVTLAIRQNDVTNNVSWISALPEIREELVHQQRRIAQAGGIIMDGRDIGTVVLPDAELKIFLVASVEERAERRYKENLEKGIESDFETLKEEIAARDYKDSHRKVSPLKAAEDALIFDTTGVSIDGVVQFIQEKAEKIVDMS
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXC_MAGSA
Sequence: MRQRTLKSAIGCTGVGLHSGAKVTMVLHPAEAGTGIRFRRVDIAGGGAIVPALWSSVGDTRMNTCLKNEAGVVVGTVEHLMSALAGMQIDNCLIEINGPEVPVMDGSAAPFLFLIECAGVVEQEAPRQAIKILKRVAIKDGERTASLTPSSGFSVRFEIDFGASAISRQEFFVNLTRGTFKAEVSRARTFGFEQEVAMLRAHGLARGGSLDNAVVIDSTGTKVLNDDGLRYQDEFVRHKVLDAVGDLYLAGAPLLGHYHGVRAGHAVTNQLLRALFADATAWELTTIAPGSAAAPFAAQPLAIAANG
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: SODM_GEOSE
Sequence: MPFELPALPYPYDALEPHIDKETMNIHHTKHHNTYVTNLNAALEGHPDLQNKSLEELLSNLEALPESIRTAVRNNGGGHANHSLFWTILSPNGGGEPTGELADAINKKFGSFTAFKDEFSKAAAGRFGSGWAWLVVNNGELEITSTPNQDSPIMEGKTPILGLDVWEHAYYLKYQNRRPEYIAAFWNVVNWDEVAKRYSEAKAK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: ENGB_KORVE
Sequence: MRVLTRFMLSAADARQFPAAGAPEIAFLGRSNVGKSSLINAIVGSKIAKTSSTPGRTQTINFFEIRRPGKPRPDWIFADLPGYGYARVPKELTAEWPKFIDPYLHERPTLALCVSIVDVSVPPQKKDLELLNWLRHVGRPFVVVGTKIDRVSGNQLRNNLLKLKEELLVEEVVPFSAKGTTGHNELWKKIFEAAGTDAPATAG
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: NAGB_ALIFM
Sequence: MRLIPLNRAEQVGAWSAQHIVNRINAFNPTADRPFVLGLPTGGTPLNTYKKLIELHKAGEVSFKNVVTFNMDEYVGLPADHPESYRTFMHENFFNHIDIQPENINLLNGNAEDHEAECQRYEDKIKSYGRINLFMGGVGNDGHIAFNEPASSLSSRTRIKTLTEDTRIANSRFFGGDMNLVPEYSLTIGVGTLLDSEEIMILITGHNKGLALQAAVEGSVNHLWTVSALQLHPKSVIVCDEPSTQELKVKTVKYFQQLEAKNMEGF
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: RL4_TERTT
Sequence: MELSIVTPQGAKGTVAVSEVAFGKEFNQDLVHQAVVAYMAGSRQGTKAQKNRAAVSGGGKKPWRQKGTGRARAGTIRSPIWRSGGVTFAAQPRDFEQKLNKKMYRAALRCILSELARQERLVVVEEFDLDAPKTKILVQKLAEYDLTDALIVSEQVSENLYLAARNLHKVDVRDVQAIDPVSLIRFEKVVMTVSAVKKLEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ATPF_HALHL
Sequence: MNFGATFWGPMISFALFVWFTMKFVWPPIQQALADRQKQIADGLAAGERGKEELDKAQAEVEAMLRDAREQASQIINQANKRQAEMIEEARAEARSEADRILASAREEIDQEIQRAREDLRKQVSTIAVQASSQILKREVDAKAHKDLIDELATQI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PANB_CAMJJ
Sequence: MRKSMISFLEKKAKNEKITMVSAYDYHSAKILDNCDIDIILVGDSLAMTVLGMQDTLSVTMDEMLIFTKAVSRGAKKSFVLADMPFMSYQSSDRDAILNASRFIKESHANGVKVEGGIEIASKIKLISQSGIPVVAHLGLTPQAVNMLGGYRVQGKDLQSAQKIIDDAKAVQDAGACMLVVECVPVKLAQKISSILEIPTIGIGSGKYCDGQVLVYHDLLGLNKDFKAKFVKHFDKIDPQVGVEKYRDEVKSGIFPSQEHSFDYLDDELLDKLY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDC1_ARATH
Sequence: MAVLSSVSSLIPFSYGATRLTSKASLASRTSGFNLSSRWNSTRNSPMLYLSRAVTNNSGTTEISDNETAPRTYSWPDNKRPRVCILGGGFGGLYTALRLESLVWPEDKKPQVVLVDQSERFVFKPMLYELLSGEVDVWEIAPRFSDLLTNTGIQFLRDRVKTLLPCDHLGVNGSEISVTGGTVLLESGFKIEYDWLVLALGAESKLDVVPGAMELAFPFYTLEDAIRVNEKLSKLERKNFKDGSAIKVAVVGCGYAGVELAATISERLQDRGIVQSINVSKNILTSAPDGNREAAMKVLTSRKVQLLLGYLVQSIKRASNLEEDEGYFLELQPAERGLESQIIEADIVLWTVGAKPLLTKLEPSGPNVLPLNARGQAETDETLRVKGHPRIFALGDSSSLRDSNGKILPTTAQVAFQEADFTGWNIWAAINNRPLLPFRFQNLGEMMTLGRYDAAISPSFIEGLTLEGPIGHAARKLAYLIRLPTDEHRFKVGISWFAKSAVDSIALLQSNLTKVLSGS
What is the function of this protein?
Bifunctional oxidoreductase ables to act both on prenyl naphthoquinones and on prenyl benzoquinones (PubMed:21844348, PubMed:26023160).  May serve a respiratory function (PubMed:12972666).  Involved in an electron flow toward the plastoglobule plastoquinone pool (PubMed:21844348, PubMed:25018761).  Required for plastochromanol-8 accumulation and for phylloquinone (vitamin K1) production (PubMed:21844348, PubMed:25018761).  Probably not directly involved in cyclic or chlororespiratory electron flows under standard growth conditions, but participates in the redox metabolism of plastoquinone-9 and the tocophrol recycling-intermediate alpha-tocopherol quinone (PubMed:21844348, PubMed:25018761).  Catalyzes the penultimate step in the biosynthesis of vitamin K1 (PubMed:26023160).
What are the official names of this protein?
Alternative NAD(P)H-ubiquinone oxidoreductase C1, chloroplastic/mitochondrial, Alternative NADH dehydrogenase NDC1, Demethylphylloquinone reductase NDC1, NADH:ubiquinone reductase (non-electrogenic) NDC1.
What is the protein family that this protein belongs to?
Belongs to the NADH dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Plastid, chloroplast. Plastid, chloroplast, plastoglobule.
Protein: UNG_ACIAD
Sequence: MQLTEQQHDKLSKVQLDESWKHSLAEFLVSSRMDELRQFLIEQKNQDKVIYPPSKQIFNALNTTPLSAVKVVILGQDPYHGPNQANGLSFSVQKGIVLPPSLRNIFHELNTDLGIPVPKHGDLTKWADQGVLLLNSVLTVEAGQPTSHQKRGWEQFTDSIIDVLNEQREHVVFILWGAYAQRKGQRIDREKHLVLKAAHPSPLAANRGGFFGCKVFSKTNNYLKQHGIEPIDWQLDA
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_PSESM
Sequence: MSQVNMRDMLKAGVHFGHQTRYWNPKMGKYIFGARNKIHIINLEKTLPMFNEALTFVERLASGKNKILFVGTKRSAGKIVAEEAARCGSPYVDHRWLGGMLTNFKTIRQSIKRLRELEVQAEDGTFAKLTKKEALMRTRDLEKLDRSLGGIKDMGGLPDALFVIDVDHERIAITEANKLGIPVIGVVDTNSSPEGVDYIIPGNDDAIRAIQLYMGSMADAVIRGRNNVAGGTDVFVEEAPAAAAVEG
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RS10_GLUDA
Sequence: MDNQNIRIRLKAYDHRVLDNSTKEIVNTAKRTGARVRGPIPLPTHIEKFTVNRSPHVDKKSREQFEIRTHRRLLDIVEPTPQTVDALMKLDLAAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PLAT3_PONAB
Sequence: MRAPIPEPKPGDLIEIFRPFYRHWAIYVGDGYVVHLAPPSEVAGAGAASVMSALTDKAIVKKELLYDVAGSDKYQVNNKHDDKYSPLPCSKIIQRAEELVGQEVLYKLTSENCEHFVNELRYGVARSDQVRDVIIAASAAGMGLAAMSLIGVMFSRNKRQKQ
What is the function of this protein?
Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity).  Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity).  For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity).  Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity).  Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (By similarity).  Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (By similarity).  Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light.  Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity).
What are the official names of this protein?
Phospholipase A and acyltransferase 3, Group XVI phospholipase A2, H-rev 107 protein homolog, HRAS-like suppressor 3, HRSL3.
What is the protein family that this protein belongs to?
Belongs to the H-rev107 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Peroxisome membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Nucleus envelope. Lysosome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=During eye lens differentiation, recruited from the cytosol to various organelles, including mitochondria, endoplasmic reticulum, nuclear envelope and lysosomes, immediately before organelle degradation. This translocation is triggered by organelle membrane damage and requires the C-terminal transmembrane domain.
Protein: CS66_WHEAT
Sequence: MDHQAHGAGEKKGIMEKIKEKLPGGHGDHKETAGAHGHAGTVTHGAPATGGAYGQEGHTGTTGTGLHGAHAGEKKGVMENIKDKLPGGHADHQQTGGTYGQQGHTGTATHGTLATGGTYGQQGHTGTAMHGTPATNGTYGEHGHTGTATGGSYGEQRHTGVTGTGTHDIGEKKSLMENIKEKLPGGHGDNQQTAGTYGQQGHFATGTHGTPATGGTYGEQGHAGVTGTGTHGTGEKKGLMENIKDKLPGGHGDHQQTGGTYGQQGHTGAATHGTPAGGGTYEQHGHTGMTGTGTHGTGGKKGVMENIKDKLPGGHSDNQQTGGAYEQQGHTGAATHGTPASGGTYEQHGHTGMTGTGTHGTGEKKAVMENIKDKLPGGHGDHQQTGGAYGQQGHTGTATHGTPAGGGTYEQHGNTGMTGTETHGTTATGGTHGQHGHTGTTGTGTHGTDGVGEKKSLMDKIKDKLPGQH
What is the function of this protein?
May reduce intracellular freezing damage during winter by hydrogen-bonding to the lattice of the nascent ice crystals, thus modifying the structure and/or propagation of ice crystals.
What are the official names of this protein?
Cold shock protein CS66.
What is the protein family that this protein belongs to?
Belongs to the plant dehydrin family.
Protein: 3HIDH_CAEEL
Sequence: MSLTGFIGLGNMGGHMARNLIKNGKKLIVYDVNKAVVQEFKAEGCEVAAHPADIAAASKEIITVLPSSPHVKAVYQGEAGIFKTIQPGTLCMDSSTIDQIVSLEVAQAAALLKAEYIDAPISGGVTGAQQATLTFMVGAGNDATFKRAEAVLSLMGKNIVNLGAVGNGTAAKICNNMLLGIQMVAVAETMNLGISMGLDAKALAGIVNTSSGRCWSSDTYNPVPGVIENIPSCRGYAGGFGTTLMAKDLSLAQNASTNTQAPTPMGSLAHQIYRILARDPQYQAKDFGVVYQFLKKQNS
What are the official names of this protein?
Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial, HIBADH.
What is the protein family that this protein belongs to?
Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SRY_MIRLE
Sequence: MFGVLNSSDHRAAVQQRNIPAFGRTSFELWTDSPTSNHRCETGGNGRDSGQNRVRRPMNAFMVWSRDHRRRVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAASSSTLCRQVLVDEKWYPFTYRDSCSRAAHPRMEDHLSSSQPVNIANSLLQQEHHYCSTSLRDSPETLAMHLSADPPF
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: WZYE_YERPB
Sequence: MTLGQFGGLFCIYLIAVIFILTLTYQEFRRVKFNFNVLFSMLYLLTFYFGFPLTCMLVFQFGVAVVPVEYLLYAMLSATAFYGIYYVTYKTRLRQPRSQPRTPIFTMNRVETNLTWVLLALVAVGTVGIFFMQNGFLLFKLDSYSKIFSSDVSGVALKRFFYFFIPAMLVVYFLKQDRRAWFFFLASTVAFGILTYVIVGGTRANIIIAFSLFLFIGIVRGWITLWMLAAAGVFGIVGMFWLALKRYGLDVNGAEAFYTFLYLTRDTFSPWENLGLLLQNYDKIDFQGLAPIVRDFYVFIPSALWPERPDLVLNTANYFTWDVLDNHSGLAISPTLIGSLVVMGGVLFIPLGAIVVGLIIKWFDWLYEQGKAESNRYKAAILQSFCFGAVFNIIVLAREGLDSFVSRVVFFCVIFGACLVLAKLLYWLFDTAGLIKRQGIKSNRLSTPNAGNQL
What is the function of this protein?
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
What are the official names of this protein?
Probable ECA polymerase.
What is the protein family that this protein belongs to?
Belongs to the WzyE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SEH1A_XENLA
Sequence: MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSENGNWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGVVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNIMGKVQIYEYNENTRKYAKAETLMSVSDPVHDIAFAPNLGRSFHILAVATKDVRIFTMKPLRKELSSSGGVTKFEIHTVAQFDNHNSQVWRVSWNITGTVLASSGDDGTVRLWKANYMDNWKCIGVLKGDGNPVGNSYQGFFGSSVGSAGQSLQNSVNGTPSSGRKHS
What is the function of this protein?
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
What are the official names of this protein?
Nucleoporin SEH1-A, GATOR complex protein SEH1-A, Nup107-160 subcomplex subunit seh1-A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC13 family.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex. Lysosome membrane.
Protein: OE56_NPVBM
Sequence: MSFFTNLRRVNKLYPNQASFLADNTRLLTSTPAGFTNVLNAPSVRNLGNNRYQPGYQLSNNRFVSTSDINRITRNNDVPNIRNVFQGISDPQINSLRQLRRMDNVPDFHYHTKQTRSNAVRQNFPETNVRTPEGVQNALQQNPRLHNHMRTLKVAGVGILLAGGGYLLFTASTLVQDIINAINRTGGSYYVQGRNAGENVESCLLLQRTCRQDRNLAQSDVNICSRDPLLANDSPLLTNMCQGFNYETEKTVCRGSNPAANPNSPQYVDISDLPAGQTIMCIEPYSFSDLVGDLGLDWLLGREGLVGKSSNSSDGIRNKIMPIIMMIGAVLFLGLILYFIYRYMTKGGGGGGGSGGAPTPIVIMQHPASTTAPRR
What is the function of this protein?
Structural protein that is specific for occlusion-derived virus (ODV) envelopes but not of budded virus (BV).
What are the official names of this protein?
Occlusion-derived virus envelope protein E56, ODV-E56, ODVP-6E.
What is the protein family that this protein belongs to?
Belongs to the baculoviridae E56 family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Note=Localized to the envelope region of preoccluded bundles of virions.
Protein: TPA_PELSA
Sequence: FLGTINLSLCEQERDADEEERRDEPNESNVEVEKRFLSGIVGMLGKLFGK
What is the function of this protein?
Amphipathic alpha-helical antimicrobial peptide with highly potent activity against Gram-positive bacteria, and potent activity Gram-negative bacteria and fungi (MIC=2-30 uM) (PubMed:18584916, PubMed:18795798, PubMed:28319176).  Acts through membranolytic mechanism involving rapid membrane permeabilization and depolarization (PubMed:28319176, PubMed:18795798).  Shows a direct extra-cellular antiviral activity probably through degradation of the viral envelope (PubMed:30669255).  Also shows a weak indirect antiviral activity by inhibiting virus replication (PubMed:30669255).  Also displays anti-trypanosoma and anti-leishmania (prosmastigotes and axenic amastigotes) activity through membranolytic mechanism (PubMed:18584916, PubMed:25668079).  Also induces apoptosis in leishmania promastigotes at high peptide concentrations (PubMed:28319176).  Shows moderate hemolytic activity (LC(50)=25 uM) (PubMed:18584916, PubMed:18795798).  In contrast to many antibiotics, this peptide does not induce bacterial resistance (PubMed:28319176).
What are the official names of this protein?
Temporin-SHa, Temporin-1Sa, Temp-1Sa.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=May insert into the lipid bilayer with an in-plane (parallel) orientation.