Protein: CAD99_DROME
Sequence: MAARNSLTPQQGLGFFGLLILLCSAVLGKSQMCEVETGQTNIILDIEESRESFIGQPTTPPELPIFGDPDTEIALNLVFPKGQPIFQLNGKKLQLLQPLDRDEENLSHIVFQVSCTTRSTGKKRTIPIIVRVSDINDNAPRFMNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSFIYSGCVSLDGACINPEYSASVPAGSLLGVLTVLPERIQAVDLDTINSPIRYSFASGMPGNYADYFQIDESTGVLKQTKAVDTSTAKKYDIIVKAEEVSPGPQRFTTAKLEIFVKPVDANPPVISSSQAEGYVDENSPIGTRVLDAHGNPISFMTTDADLSDSDPKPDYIYELTTPSFNVTGDGILVVNEENLDRDPPAPGRFKFQVVAREPRTNAASAPLSLTVHLRDVNDNAPKLAMVAPISITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTGEIRTQGRLLAGEQYSITVQATDIGGLSSQAIVEVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAEDPENDAVVYSIISGNDLRQFAVGQESGVIIVIRKLDRESLTRYQLILKAEDTGGLSSSATVNIKVTDINDKNPEFEASTLPYVFQVEEGKAQASVGVVHATDADEGINAEITYSIPTDIPFTINATSGEILTAKELDYEQLNEYKFVVTAKDGAPDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPENEENFLVATVQAFDPDSMPEITYVLRKGNAELFKVSEKSGEVRTIKGLDYESQKQHQLTIGTIENDGNGPGDTILLVVDVEDRNDLPPRFITVPDPVTVNDDQGIGTIIATLPAIDGDGTSPGNVVRYEIVGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDDSYTTSVPESMEANSTLKLIQIVNSKTSGDGPPAFRCEFVSGNGGGIFNLSSADHGCNLLLIQPLDFENKSSYSLQLRLTSHRYFVNPLKDTTSVEIIVQDENDNAPEFEFNRLRGQQDTFYTVVTEEMDVDTTILQVRATDRDSGKFGTVRYTLYDDDENRVNMPTSFFMMSEDTGVLRTAKHFKNENDFPLTFLVEARDSDGQEQGSHRTRARIVVNKLADINRMALSFPNAAPSDLRNYYTELEELLDKKTGLVSGIERMSSQKYLAKNGSVIENPAATDIWFYLIDPKTEQLVSRKDSIVETTLLEPAARSELNIALPRATAENISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGIIYICISWSKYKNFKQRMRQYSSTNPPRYDPVIVNQQASSASETIANMKEYETQMLAMAVPPDVDDDLQLDFSAKNHAFSLDNVSYITHKENTNGGGQSSPSHSDATTATIATLRRHKNLNNASMNNNLAINNRQNTFNRTLEMNTRNNANPLASPPNGALSGTLTLGRIKHQNSNHYQNGAYNIDPTGPNNMAHAKNNAYSTMGRRGNTFGDVGLLNGNGELMNATLGRNGQLNNRLYGGEVPITNPLFQRSNSDHNHLSSTNENVSFGKRDYGQIGFSYLNDLDRSEVETTTEL
What is the function of this protein?
Cadherin that functions in epithelial morphogenesis and the intestine epithelial immune response (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25639794).  Essential for female fertility (PubMed:16260500, PubMed:16507588).  Regulates the length and organization of apical microvilli in developing follicle cells and salivary glands (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25236597).  Function in the follicle cell is essential for egg development as the microvilli secrete eggshell material such as the vitelline membrane (PubMed:16260500, PubMed:16507588, PubMed:25236597).  Acts at least in part by regulating the recruitment of the myosin ck to the follicle cell microvilli (PubMed:25236597).  Also required to regulate cell rearrangements during salivary tube elongation, possibly by modulating cellular adhesion between the apical surface and apical extracellular matrix during epithelial tube elongation (PubMed:24718992).  May also function in cellular adhesion during the development of other tubular epithelia such as the trachea (PubMed:24718992).  Possibly functions as an apical membrane determinant which acts in apical membrane expansion during salivary and tracheal epithelial tube elongation (PubMed:24718992).  In salivary gland development, this function is independent of the other apical membrane determinants crb and sas (PubMed:24718992).  Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut epithelial immune response to bacterial uracil; required for endosome formation in the enterocyte and activating norpA-dependent Ca2+ mobilization, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).
What are the official names of this protein?
Cadherin-99C.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Note=Dispersed throughout the enterocyte membrane, but becomes clustered in the brush border membrane in response to uracil.