PharMolix/UniProtQA huggingface dataset:
Protein: SYK_METTH
Sequence: MKFTHFFVALILSRFLQVISLKHWIERIADELKERDVEEHVVASGTSISGSIHIGNSCDVFIASSIAKSLKKDGFKSRTVWIADDHDPLRKVPYPLPESYEKYLGVPYSMIPCPEGCCESFVEHFQRPFLEALERFRIGVEHYSGARMYTEGLYNDYIRTSLERAPEIREIFNRFRDRPLRDDWLPYNPICEKCGRVNTTEAYDFSGDTVRYRCECGFDGEMDIKSGLGKLTWRVEWAARWKILGVTCEPFGKDHAASGGSYDVSSIISEEIFDYPAPYPVPYEWITLRGEAMSKSRGVFFTPGQWLEIGPPESLNYFIFRSKPMKHKDFNPDMPFLDLMDQFDRTERIYYGMEDAASEKEEQKLRNIYRVSMIEEFDLPLRPSYRFMTVACQIAGDDPERLYDILRRNSQLPEELMDLELDQLTDKQLEQLNERIENVKNWLRLYAPEFVKFQVQEELPDVELSEPQLKFLQDVADLMESREMSAEELHDEMYSILRRHGLKPQKAFQAIYRVLIGKKMGPRAASFLLSLERDFVIRRLRLEA
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_DICT6
Sequence: MFIDRAKIYVKAGDGGNGCVAFRREKFVPRGGPAGGDGGKGGDVIIEADENLDTLLDFHYKRHYYAERGEHGKGKNQKGKDGEDLIIKVPTGTLIFDAETGELIADLVSHGQRVVVARGGKGGRGNTHFATSTRQAPYFAEKGEKGEERWLYLELKLLADVGLVGLPNAGKSTLLSKISNANPEIAPYPFTTKTPNLGVVEREDITFTVADIPGLIEGAHENKGMGDEFLRHIERTLVLVFVIDAADLVTPPQKAYEILKKELYLYSPKLLEKPRIIAINKIDLPEAQERLPEIEKWLKNEGVPYVFISAKEGINIDKLLELMEKYVRERKESIPVVEVDKEIQETKEGRVETEEIPEVIREKDLWILKDKKTESLANKLDLYNPQAFSYFSNYIKRRGIIKLINRAKVKDGEKIKIGDYIFKYNAKTNSLEILE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4667_PSEAE
Sequence: MMAPPSQVQGRLSSSMNKSLALLTVTLLLGGCQSLIHKTPDGTPPVEDTAVETKAKPEKYGSFSEDSLYSLLVAELAGQRNRFDIALSNYVVQAQKTRDPGVSERAFRIAEYLGADQEALDTSLLWARSAPDNLDAQRAAAIQLARAGRYEESMVYMEKVLNGQGDTHFDFLALSAAETDPDTRAGLLQSFDHLLKKYPNNGQLLFGKALLLQQDGRPDEALTLLEDNSASRHEVAPLLLRSRLLQSMKRSDEALPLLKAGIKEHPDDKRVRLAYARLLVEQNRLDDAKAEFAGLVQQFPDDDDLRFSLALVCLEAQAWDEARIYLEELVERDSHVDAAHFNLGRLAEEQKDTARALDEYAQVGPGNDFLPAQLRQTDVLLKAGRVDEAAQRLDKARSEQPDYAIQLYLIEAEALSNNDQQEKAWQAIQEGLKQYPEDLNLLYTRSMLAEKRNDLAQMEKDLRFVIAREPDNAMALNALGYTLADRTTRYGEARELILKAHKLNPDDPAILDSMGWINYRQGKLADAERYLRQALQRYPDHEVAAHLGEVLWAQGRQGDARAIWREYLDKQPDSDVLRRTIKRLTGAETP
What are the official names of this protein?
TPR repeat-containing protein PA4667.
Protein: ELMO3_RAT
Sequence: MAPPRNVVKIAVQMSDAIPQLIQLDQAKPLATVLKEVCDTWSLTHPEHYALQFADGHRKYITENNRSEIKNGSILCLSTAPDLKAQQLLSRLQNASREGCCEVLRNLVPLASDMTFAQEVISRDGLQKLSTIIENGDDLGEMLALGLRAFLELMEHGVVSWETLSISFVRKVVSYVNMNLMDASVQPLALRLLESVTLSSPTLGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGASPAERKDMLDCLWKKNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALTLGLLEPRMRTPLDPYSQEQREQLQALRQAAFEPDGESLGTGLSADRRRSLCVREFRKLGFSNSSPAQDLERVPPGLLALDNMLYFSRHAPSAYSRFVLENSSREDKHECPFARSSIQLTVLLCELLHVGEPCSETAQDFSPMFFSQDHSFHELFCVAIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGMLFRKISSRRRQDKLWFCCLSPNHKVLQYGDVEEGANPPTLESLTEQLPVADIRALLMGKDCPHVREKGSGKQNKDLYELAFSISYDHGEEEAYLNFIAPSKRDFYLWTDGLSALLGSTMGSEQTRLDLEQLLTMETKLRLLELENVPIPEHPPPVPPPPTNFNFCYDYSMTEP
What is the function of this protein?
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.  Acts in association with DOCK1 and CRK.  Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases.  May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).
What are the official names of this protein?
Engulfment and cell motility protein 3.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_STRSV
Sequence: MSIKVIIAGFKGKMGQAAYKMVTEDSELELVGLLDPFTDEKEVAGVPVFNAKEELAGLEAHVWVDFTTPKVAYDNTRFALEQGFCPVVGTTGFTPEQLEELITLSREKKLGGLIAPNFALGAVLLMQFAAQAAKYFANVEIIELHHDQKKDAPSGTAIKTAELISQVRPSKQQGAADEEESIVGARGADFDGMRIHSVRLPGLVAHQEVIFGSQGEGLTMRHDSYDRASFMTGVNLAIKEVVKRSELVYGLEHLL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_MAMPR
Sequence: MTHIRKSHPLLKILNKSFIDLPTPSNISTWWNFGSLLGACLITQILTGLFLAMHYTPDTMTAFSSMSHICRDVNYGWIIRQLHSNGASIFFLCLYTHIGRNIYYGSYLYSETWNTGIMLLLITMATAFMGYVLPWGQMSFWGATVITNLFSAIPYIGTDLVEWIWGGFSVDKATLNRFFALHFILPFTMIALAGVHLTFLHETGSNNPLGLTSDSDKIPFHPYYTIKDFLGLLILILFLLLLALLSPDMLGDPDNYMPADPLNTPLHIKPEWYFLFAYAILRSVPNKLGGVLALLLSILILGIMPLLHTSKHRSMMLRPLSQVLFWTLATDLLMLTWIGSQPVEYPYIIIGQMASILYFSIILAFLPIAGMIENYLIK
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: H4_MYTCA
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: KTX21_TITSE
Sequence: MNKVYLVAILVLSVLLVANVSPIEGVPTGGCPLSDALCAKYCKSNKYGKTGKCTGTSKGTCKCLV
What is the function of this protein?
This recombinant toxin inhibits the mammalian voltage-gated potassium channels Kv1. 3/KCNA3 in vitro with an IC(50) of 26. 40 nM.
What are the official names of this protein?
Putative potassium channel toxin Ts21, Putative KTx, Tityustoxin-21.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 11 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MRAZ_CERS4
Sequence: MAEAFRGEYNQKVDAKARVSIPAPFRRVIEAGDPKFSGGRSSFVLVYGGDRSYVECYTISEMERIEERIRSLPMGTPKRRYLERNMITLALNMELDEDGRIVLPPKGREKLGISPDELKGGTEATFAGTLNKFQIWKADTYAAELAAEEEVLLPPGADMLSLLEETGL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL24_SYNP6
Sequence: MAAQKPVRHSVHVKKGDTVQVIAGKDKGTVGEVLQVFPKTSRVLVKGVNLRTKHVKPRQEGESGQIVVEEASIHSSNVQLYSTTQKVASRVAYTFTEDGRKVRKLKKTGEIID
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PDXJ_NEIG1
Sequence: MLLGVNIDHIATVRNARGTTYPSPVEAALVAETHGADLITMHLREDRRHIKDADVFAVKNAIRTRLNLEMALTEEMLENALKVMPEDVCIVPEKRQEITTEGGLDVLAQQEKIAEFAKILTDAGIRVSLFIDADDRQIQAARDVGAPVVELHTGAYADAQSHAEQIRQFERIQNGAHFAGDLGLVVNAGHGLTIHNVTPVAQILAIRELNIGHSLIAQALFLGLPEAVRQMKEAMFRARLLP
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DADA_BORPA
Sequence: MHVIVLGSGVIGTTTAYYLARQGAQVTVLERRAGPADETSYGNAGQVSPGYSTPWAAPGIPLKALKWMFQKHAPLAIRADGSFYQWRWLAAMLANCSAGRYSVNKERMLRLAEYSRDCLRTLRADTGIQYEQRTQGTLQLFRTAAQMEAARRDIAVLEECGVPYELLDRNRLPTAEPALARALDKLAGGLRLPNDETGDCRRFTLQLADKAKALGVQFRFNQQVEGLDVRGGQVAGVRVGGEQLAADCYVAAFGSYTRGFLRPLGLDLPVYPVKGYSLTIPMTDESAAPVSTILDETYKVAVTRFDQRIRVGGMAELAGFDLRLKEARRKTLELVVNDLSPGSGAVEQAEFWTGLRPMTPDSTPIIGATKYGNLFLNTGHGTLGWTMACGSGQLVADQVCGRQPAIRADDLALSRYGAGGQAGGGVARAQHNAA
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: SSTT_COLP3
Sequence: MTSEKPQNESFIQKIKSTSLVSQIIVAIILASLLAVISPESAKAFGMLGSLFVNALKAVAPILVLVLVTSAIANQKMDSSAELKPIVGLYFLGTLSAALVAVLLSFAFPTELTLDLAGATANPPQKLTEVLATLAFKVVENPVTAVASGNFIAVLAWGLGLGFSLKHASESSKGMVHDLSEAISSVVRIVIRFAPLGIFGLVANTIATTGFSALGEYSHLVAVLLSAMLIIALLVNPLIVFIITKKNPYPLVFTCLKESGITAFFTRSSAANIPVNMALCKKLDLHEDTYSVSIPLGATINMAGAAITITVLTLAAAYSLNIEVSFATAILLSVVASISACGASGVAGGSLLLIPLACSLFGINNDVAMQVVAIGFIIGVIQDSAETALNSSTDVVFSAAASHHITKE
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ALAE_CITK8
Sequence: MFSPQSRLRHAVADTFAMVVYCSVVNMLIEIFLSGMTFEQSLSSRLVAIPVNILIAWPYGMYRDAIMRVARKASPASWVKNLADVLAYVTFQSPVYVAILLTVGADWHQITAAVSSNIVISMLMGAVYGYFLDYCRRLFKVSSYHQAKA
What is the function of this protein?
Exports L-alanine.
What are the official names of this protein?
L-alanine exporter AlaE.
What is the protein family that this protein belongs to?
Belongs to the AlaE exporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MARHB_HUMAN
Sequence: MSFEGGHGGSRCRGAESGDAEPPPQPPPPPPPTPPPGEPAPVPAAPRYLPPLPASPETPERAAGPSEPLGEVAPRCRGADELPPPPLPLQPAGQEVAAAGDSGEGPRRLPEAAAAKGGPGESEAGAGGERERRGAGDQPETRSVCSSRSSSSGGGDQRAGHQHQHHQPICKICFQGAEQGELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVIAIKMKQPCQWQSISITLVEKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMYGFMDLVCIGLIVHEGAAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRGESSTSRTLWLPLTALRNRNLVHPTQLTSPRFQCGYVLLHLFNRMRPHEDLSEDNSSGEVVMRVTSV
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.  May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.
What are the official names of this protein?
E3 ubiquitin-protein ligase MARCHF11, Membrane-associated RING finger protein 11, Membrane-associated RING-CH protein XI, MARCH-XI, RING-type E3 ubiquitin transferase MARCHF11.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: ADTRP_MESAU
Sequence: MTRTTTCVYHFLVWNWYIFLNYYIPLIGKDDEKLKEFHDGGRSKYLTLLNLLLQAIFFGVACLDDVLKRIIGRKDIKFITSTRDLLFSTLVFPISTFIFLVFWTLFYYDRSLIYPKGLDDYFPAWLNHAMHTYILLFVLVETILRPHHYPSKKLGLALLGACNLAYITRVLWRYSQTGNWVYPVFASLNPLGIIIFFLVCYILNASIYLVGEKINHWKWGATVKPLMKKKK
What is the function of this protein?
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (By similarity).  Shows a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (By similarity).  Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (By similarity).
What are the official names of this protein?
Androgen-dependent TFPI-regulating protein, Androgen-dependent-expressed protein FAR-17a, Fatty acid esters of hydroxy fatty acids hydrolase ADTRP, FAHFA hydrolase ADTRP.
What is the protein family that this protein belongs to?
Belongs to the AIG1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Colocalized with TFPI and CAV1 in lipid rafts.
Protein: GLUC2_LOPAM
Sequence: MTSLHSLAGLLLLMIIQSSWQMPDQDPDRNSMLLNENSMLTEPIEPLNMKRHSEGTFSNDYSKYLETRRAQDFVQWLKNSKRNGLFRRHADGTYTSDVSSYLQDQAAKDFVSWLKAGRGRRE
What is the function of this protein?
Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
What are the official names of this protein?
Glucagon-2, Glucagon II.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPF_NITEC
Sequence: MRIRVKICGITRLEDAMTAVHHGVDAIGFILWPQSERYISPEEAGQIVRYLPPFVQAVGVFVNPDKSWVEVASAAAGLDLLQFHGDESPDFCSQFHLPYIKAVRVRDGLDLLQYAQCYEGSKGLLLDAYAEGKPGGTGHIFDWKLIPSGLSLPWILSGGLHSDNVVDAIEQTRPLAIDVSSGVEIANGIKDADKISVFMQGVRSCENV
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: TEB1_TETTS
Sequence: MKLTKGGSYILKKVDRKQFYQDEEIVMQIKKILGQKTTDCKQYIKCECIDGLGDEALIYFEMLANQNQHLQKNDVIMIQDYLNDKTQNDKIVVLVTRFQFCKASHVQPKTAQKESIQLLNTEKTIIQKSKITKNPAEEVLKFIEVNEKDNSSNSEDMIIEQQKQEIKNNQKEKQSINGFNLEDSYSNISDITNFGGKSNFNIGSLSDQLSKQTLLISQLQVGKNRFSFKFEGRVVYKSSTFQNQQDSKYFFITAQDANNQEINLSFWQKVDQSYQTLKVGQYYYFIGGEVKQFKNNLELKFKFGDYQIIPKETLSANYVQPLALQPSKQFGNDSIGDSDYSIHNLIEKEESIAQKGYNGQKNNKYRQNNNNSKHTLLISEVLKTSKQYLSVLAQVVDIQSSDKNIRLKICDNSCNQELKVVIFPDLCYEWRDKFSINKWYYFNEFVRQIYNDEVQLKNNIHSSIKESDDQRKVITYNQEQGVFKKSISINSNDSFEIKPKISYKNNSNQEQRIYSSIEEIIQQAQASEIGQKKEFYVYGNLVSIQMKNKLYYYRCTCQGKSVLKYHGDSFFCESCQQFINPQVHLMLRAFVQDSTGTIPVMIFDQQSSQLINQIDPSIHVQEAGQYVKNCIENGQEEIIRQLFSKLDFARFIFEIQFENKEFNNEQEIAYKVLKIEKENIKEESKYLLKKLEHLINNNQNN
What is the function of this protein?
Single-stranded DNA (ssDNA)-binding protein that mediates the recruitment of telomerase to telomeric DNA (PubMed:19941821, PubMed:20363756, PubMed:25225329, PubMed:22143754).  Telomerase is an essential ribonucleoprotein (RNP) enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:19941821).  Acts as part of a replication protein A (RPA)-related subcomplex of the holoenzyme telomerase ribonucleoprotein complex: TEB1 specifically recognizes and binds telomeric ssDNA, thereby mediating the recruitment of the holoenzyme telomerase RNP complex to telomeres (PubMed:19941821, PubMed:25225329, PubMed:27895115).  TEB1 is related to RPA1 subunit of the RPA complex but is specific to telomeric DNA, which is not the case of RPA1 (PubMed:25225329).
What are the official names of this protein?
Telomeric repeat-binding subunit 1, Telomerase-associated protein of 82 kDa, p82.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 1 family.
What are the subcellular locations of this protein?
Chromosome, telomere.
Protein: TXA8_ANDAU
Sequence: MMKLMLFSIIVILFSLIGSIHGADVPGNYPLDSSDDTYLCAPLGENPFCIKICRKHGVKYGYCYAFQCWCEYLEDKNVKI
What is the function of this protein?
Inhibits the vertebrate potassium channels Kv1. 1/KCNA1 and Kv1. 3/KCNA3 in vitro with an IC(50) of 5. 3 nM and 50. 0 nM respectively.
What are the official names of this protein?
Beta-toxin KAaH1, Peptide AaF1CA8.
What is the protein family that this protein belongs to?
Belongs to the long (3 C-C) scorpion toxin superfamily. Sodium/Potassium channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: TMEDA_DEBHA
Sequence: MRSISTLLFIISTFISLVSALQLAIPATTNPDPFCIRDFVQEEQMVVVNIKTNGNSGDGQRLDLRIVDSLGNEYRRKNDIAGSVKIGFTSHNSAAFDICFTNQLERKWSKNTNFVREIELDVESGAAARDWNAVQAAEKLKPVEVDLRRIEETTYEISGELQYLKAREERMRDTNESTNSRVKWFSILVITSLVGLGAWQVQYLRHYFKVKHII
What is the function of this protein?
Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles.  Required for efficient transport of a subset of secretory proteins to the Golgi.  Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).
What are the official names of this protein?
Endoplasmic reticulum vesicle protein 25.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Recycles between endoplasmic reticulum and Golgi.
Protein: ATR3_STEAL
Sequence: MTSVDTMPPPMVRLESQPDDLMGSSDVADVSDLLPGHTNGLEDEVKIPATNGLKSHPVVTTGTEKTGVMPPLQPESKKNNKGVPWYHASPNDIDPVTRGLLENYSKIPSDQVQQHVIAIREKAWDVYPYPCIGQFLFLNLTINLSPYYPSLVSRLRDQNQTLLDLGCCFAQDVRKLVSDGAPSQNIYGADLYGEFMDLGFELFRDRKTLKSTFFPTDILNERDLLLKGLDGEMDVVYLGLFLHHFDFETCVKVCTRVTRLLKPKPGSLVMGVQVGSLVGDTKPIPIPSGGILWRHDIASLERVWEEVGALTGTKWKVEARLERGKGFGEKWQLEGTRRLGFEVYRL
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of atranorin, a depside of polyketide origin that accumulates in the cortical or medullary layers of lichen thalli (PubMed:34154413).  Atr3 methylates the carboxyl group of 4-O-demethylbarbatic acid to yield proatranorin I (PubMed:34154413).  Atr3 is also able to methylate the atr2 product proatranorin III to produce the final compound atranorin (PubMed:34154413).  The first step in the pathway is performed by the non-reducing polyketide synthase atr1 that produces 4-O-demethylbarbatic acid composed of two 3-methylorsellinic acid (3MOA) moieties.  The pathway continues with the actions of the cytochrome P450 monooygenase atr2 that catalizes the oxidation of c-9 and the O-methyltransferase atr3 that performs the methylation of the carboxyl group to yield atranorin, via the proatranorin II and III intermediates if atr2 acts first, or the proatranorin I intermediate if atr3 acts first (PubMed:34154413).
What are the official names of this protein?
O-methyltransferase atr3, Atranorin biosynthesis cluster protein 3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily.
Protein: FBXW9_BOVIN
Sequence: MELPPGPRDDPHAWDDDSDPELEPDTDAQAEAYVARLLSPPKLGLAPPRAPPLPAPTVSFGSLEPRAASKGPTVAVPGLLSLPPELLLEICAYLDARLVLHVLPRVCHALRDLVRDRVTWRLRAQRRVRAPYPVVEEEDFDWPTACIELEQHLSRWADDGRRAEYFCLADGHFASIDSVLLLQGGTLCLSGSRDRNVNLWDLQQLGVEPSRVLVKTLGTQKNSTHKGWVWSLAALDHRVCSGSWDSTVKLWDMAADGQQFGEIKGKAAVLCLSYRPDILVTGTYDKKVTVYDPRVGPALLKSRRLHSSAVLALLADDRHIISGSEDHTLVVFDRRANSVLQRLQLDSYLLCMSYQEPQLWAGDNQGLLHVFANRSGCFQLVRSFDVGHRSQITGIKHSLGALYTTSTDKTIRVHVPTDPPRTICTRSHHNVLNGICAEGNLVVAASGGLSLEVWRLQA
What is the function of this protein?
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
What are the official names of this protein?
F-box/WD repeat-containing protein 9, F-box and WD-40 domain-containing protein 9.
Protein: CDPK4_PLAYO
Sequence: MGQEMSTQSDIQNEDQKGNKRNLKGTQGKNGLKERSTSISKEIVKNSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKRFYEVDAARIIKQVLSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVETGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIRLMTSKDNVNIDIPSLELSITNIKQFQSTQKLAQAALLYMGSKLTTIDETKELTKIFKKMDKNGDGQLDRNELIIGYKELLKLKGDDTTDLDNAAIEVEVDQILSSIDLDQNGYIEYSEFLTVAIDRKLLLSTERLEKAFKLFDKDGSGKISANELAQLFGLGDVSSDCWKTVLKEVDQNNDGEIDFKEFRDMLIKLCNY
What is the function of this protein?
Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase.  Plays a central role in the host erythrocytes and hepatocytes infection cycles, sexual reproduction and mosquito transmission of the parasite.  During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK1 and CDPK5.  Involved in merosome egress from host hepatocytes, probably together with CDPK5.  During the asexual blood stage, involved in merozoite invasion of host erythrocytes and motility by stabilizing the inner membrane complex, a structure below the plasma membrane which acts as an anchor for the glidosome, an acto-myosin motor.  Required for cell cycle progression in the male gametocyte.  During male gametogenesis in the mosquito gut, required to initiate the first round of DNA replication, probably by facilitating the assembly of the pre-replicative MCM complex, to assemble the first mitotic spindle and, at the end of gametogenesis, to initiate axoneme motility, cytokinesis and subsequent exflagellation.  For each of these steps, may phosphorylate SOC1, SOC2 and SOC3, respectively.  Together with CDPK1, regulates ookinete gliding in the mosquito host midgut.
What are the official names of this protein?
Calcium-dependent protein kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor.
Protein: PURA_MYCS2
Sequence: MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGENFALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELKGLEDRGVDTSNLLISADAHLLMPYHVAIDKVVERWAGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDEQVLAEKIEAALEFKNQVLVKIYNRKALEPAEVLENLLEQAEGFKHRIADARLLLNQALENDEAVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGAAVGSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVTTGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYTVDGKRVDEMPMTQSDIARAEPVYEELPGWWEDISGAREFEDLPAKARDYVLRLEELAGAYVSCIGVGPGRDQTIVRRDVLAAR
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFT43_CHLRE
Sequence: MDDDAPKAAPKAGRRAARTANTWGDDSAAPPEPQKGGFGLDSGFGGGGGSPRGNAFGAEDSAPPKHVASTNFAPSGDDEPAPAPSRQRTGDASGDRPSRGGAPPSRPPPAEILGEDSKKFVGVSRRKQEQLARGDDEVSRKNLKYETLTAGVDGIMEIPELEEEGREDLSNIVAEAPKVRTNKVQGMEELEEDMHYKLPAMDDRDIDLSLLTAVLCSSEQVAEAEDPWDPDIVLTEVASAINAEREKAEGGEAPDDMGGMRDEQGMPMPIKL
What is the function of this protein?
As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis.  Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.
What are the official names of this protein?
Intraflagellar transport protein 43.