PharMolix/UniProtQA huggingface dataset:
Protein: DMAT1_GIBF5
Sequence: MLLQASQATQSVWKTLNKWLPPLSRDKDWWWKTLGPQINTLLTEADYDLNERYEALLLLYRWVVPEMGPRPRSSVAPSKSFMTDDHSPIEYSWKWISGNKKPEIRYAVELVSPLAGSKQDPFNQIPTRNLVYNLAKIIPELDLTWFEHFWHELLGPGSPTTSTSGVLTKGSTVFAALEMLHGHLSVKVYFIPVETPDFSAWHQIKHAIEASGCPNLEALNHVDAYLSSHDDGRQLRPFMLAIDLVEPAASRLKIYARSNQTSFRFVRDVMTIGGLRTDLDRSIEKFSDLWKRALGLDPDTPPEDELPKVDHLTSGAVFNFDVAPKSQIPEVKAYIPVRHYANNDLQAALGLIGYLEDHGHGGYSQSYLRGLDMLAPSGQLDQATGVQTYFAVACQGEDLSLTSYLNPQFYAAFQEPERT
What is the function of this protein?
Dimethylallyltryptophan synthase; part of the DMATS1 gene cluster that mediates the biosynthesis of a reversely N-prenylated monomeric L-tryptophan (r-N-DMAT) (PubMed:28295904).  The main product of the cluster is the r-N-DMAT produced by the dimethylallyltryptophan synthase DMATS1 and it remains unclear whether this metabolite undergoes further modifications when silent gene clusters are activated (PubMed:28295904).  The acetylated form of r-N-DMAT, ac-r-N-DMAT, is also produced (PubMed:28295904).  The roles of the cytochrome P450 monooxygenase FFUJ_09176 and the methyltransferase FFUJ_09178 have still to be elucidated (Probable).
What are the official names of this protein?
Dimethylallyltryptophan synthase 1, DMATS 1, DMATS1 biosynthesis cluster protein DMATS1.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: TCAA_STAAE
Sequence: MKSCPKCGQQAQDDVQICTQCGHKFDSRQALYRKSTDEDIQTNNIKMRKMVPWAIGFFILILIIILFFLLRNFNSPEAQTKILVNAIENNDKQKVATLLSTKDNKVDSEEAKVYINYIKDEVGLKQFVSDLKNTVHKLNKSKTSVASYIQTRSGQNILRVSKNGTRYIFFDNMSFTAPTKQPIVKPKEKTKYEFKSGGKKKMVIAEANKVTPIGNFIPGTYRIPAMKSTENGDFAGHLKFDFRQSNSETVDVTEDFEEANISVTLKGDTKLNDSSKKVTINDHEMAFSSSKTYGPYPQNKDITISASGKAKDKTFTTQTKTIKASDLKYNTEITLNFDSEDIEDYVEKKEKEENSLKNKLIEFFAGYSLANNAAFNQSDFDFVSSYIKKGSSFYDDVKKRVSKGSLMMISSPQIIDAEKHGDKITATVRLINENGKQVDKEYELEQGSQDRLQLIKTSEK
What is the function of this protein?
Plays a major role in decreasing resistance to glycopeptide antibiotics.
What are the official names of this protein?
Membrane-associated protein TcaA.
What is the protein family that this protein belongs to?
Belongs to the TcaA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: CBID_SALTI
Sequence: MSELSFDAPVWRHGKALRKGYTTGSCATAAAKVAELMVLRQHLIHQVSIVTPSGVTLCLNVESPHIEGQQAIAAIRKDGGDDVDATHGMLIFARVTLNDSGEITLTGGEGIGTVTRKGVGLPLGSAAINRTPRHTIESAVREAIGPARGADVEIFAPEGEVRAQKTYNSRLGILGGISIIGTTGIVTPMSEESWKRSLSLELEIKRASGLTRVILVPGNHGERFVREQMGVDTQAVVTMSNFVGYMIEEAVRLGFCQIVLVGHPGKLIKIAAGIFHTHSHIADARMETLVAHLALLGAPLELLTLVGDCDTTEAAMEHIEAYGFGHIYNHLARRICLRVMQMLRFTKTPPVCDAILFSFDNHILGSNRPVDEIAKELQC
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: RS16_SYNC1
Sequence: MSVKIRLARGGAKKKPFYQVVVADERFPRDGRFIEQLGQYDPRQNPSMVTLKEDKTLEWLNKGAQPTDTVRRLLRTQGVWAKFKQA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: ASNA_LACH4
Sequence: MTLILPKDYRPTLTVRDTEAAIVFIRETFQDKLASILGVQRMSAPMFVEQKTGLNDNLNGVERPVAFDMKAMPKEDTIEIVHSLAKWKRLALKKYGFGIHEGLYTNMNAIRRDEDLDNFHSIYVDQWDWEKIIRKEERNTDTLEITVNKIFRAIKETEKLVSARHPGSTYRLGDHVSFITTQELEDRWPDLSPDERENQIAKEEKVVFIMKIGDKLKRSGKPHDGRAPDYDDWQLNGDLVFWYEPLQSKIEISSMGIRVSEESLKEQLKKAHCEERAKLPFHQMILKGELPYSIGGGIGQSRLCMLLLGKAHIGEVQASIWPEDMVEKCEADNIELL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED14_CANAL
Sequence: MPNGKQQHEVTESSSPPEIPHITANMIPLSNIIKYYTQEAYKQLTTAIENLSMNVNEESDIKRKKYFLNVIINLRQDFIKVYTLIKWASISKDVSKFIDLLNWFRIQEFHFENLIFQLNALTGYNAAKLPNSDIITALEVLYHGRPKLPSYNYIKSDNLSPQKILETLNDLNLVLMTRFALMDNIPKRFDYEIKDGRAYIRVSNEFEVSITVGNDLIIDNPEEYYKSPFYFIDFKFLFGANPESGLITFNDDKISTKLPTSSHKKLEKLVNQTLLTRGLQGLYELLHKYSNSFKIYLLAKQFQTLLINSRWRGNFQINYQTNKSLIVINYWSQHYLSRNWKSFIELGIDSHSNLNYRWFKNGQYCFGDQGNNELDKIFHLQRRNSNNGVTTSSNTISTSAMIAGIRRSTELSNETAIVDDNDNDNDDTNNTGETENEDLNVDLILNVVVNQHAKSIMSEIYSQLLTRFSETDVSMVSPHQLLLQISPKKSTVFAINPLTGFFYFIDPTPIQTYITKKINSPPPTLSQVSIKQSFIPESDMISYVIDQIIQLRLEVFNKEVNTKLATTAWINNGIIKLSDHELSKLTQFLIQNEEQEGDDNEEDSSTNTRLDSVLQSFKVQFYRRKNWPSSWFLINMISGVTTKSFWWVARIKSISGDWKIQWAQIIKFHGDNAKQELSPNESKVFDKPKRTVDCSIESEQLNFEFFKTLSTLSSNLILDHMILEELQVRSIKFIKLDWETIDDNKIFSKFKQNHDISLKRKNSHNINIDVNVDVADNTSTTTNTKYIRAPKLKYESMFLIYNDKLLPIYNSATILFLKIELVESNKMYLKLFGNLRNLQIKNTSEDIQKLHLNIDEANQYFEIDNTVDLSTVINEPKTLLLNLIFNTLNKLNSLIKILDQLNKSNVTVLDNSMDNITINIKDKYNDNNDKLIIIKLPEQATDSIQLLMKNGSTTTTDEIDLRNNNILEFELILKFLNQYLRESKSNNHNRQQISIIKIIQYLTEINPILQSTKAINQQLAELKRINSTNNNNNNAKRRSILKLSNGLYKLYFNLNIISLTHLQLVFFMNSNTGSNLKKIQRDKIMINLSLIKFDRFSKPNGNFQDSTNGHLIKISFKDSLINENLKFKNLFEIIFKNINELLITKSKQIKSLNQTENQQQQQPLKQEDNSDSAIIKKESQSIEDDLLDFGEYDNDIKPQQQEPQQNEKENSKTTSKENETVRPDDILIKLNYDYLLSMNNLQLMINEITKSCFQYLQQQQE
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 14, Mediator complex subunit 14.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RN126_BOVIN
Sequence: MAEASPQPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSAENGSAPSTASADQSRQQPFENVDQPLFTLPQGYGHFAFGIFDDSFEIPTFPPGAQADDSRDPESRREREQHSRHRYGARQPRARLTARRATGRHEGVPTLEGIIQQLVNGIITPATIPNLGLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYGLGEHVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATDPPGLAGVSFSSSSSSSSSSPGNENPASSS
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins.  Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates.  Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome.  Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome.  May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor.  May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination.  By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation.  May monoubiquitinate AICDA.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF126, RING finger protein 126.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: VP6_ROTHC
Sequence: MDVLFSIAKTVSDLKKKVVVGTIYTNVEDVVQQTNELIRTLNGNIFHTGGIGTQPQKEWNFQLPQLGTTLLNLDDNYVQSTRGIIDFLSSFIEAVCDDEIVREASRNGMQPQSPALILLSSSKFKTINFNNSSQSIKNWNAQSRRENPVYEYKNPMLFEYKNSYILQRANPQFGSVMGLRYYTTSNTCQIAAFDSTLAENAPNNTQRFVYNGRLKRPISNVLMKIEAGAPNISNPTILPDPNNQTTWLFNPVQLMNGTFTIEFYNNGQLIDMVRNMGIVTVRTFDSYRITIDMIRPAAMTQYVQRIFPQGGPYHFQATYMLTLSILDATTESVLCDSHSVEYSIVANVRRDSAMPAGTVFQPGFPWEHTLSNYTVAQEDNLERLLLIASVKRMVM
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices.  This capsid constitutes the middle concentric layer of the viral mature particle.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes.  VP6 is required for the transcription activity of the DLP.
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: CSRA_AERS4
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYMRIQAEKVPGQPNF
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METXA_METEZ
Sequence: MKYKSIGNVETKYYQIPEELVLESGKKISDVTLAYETYGTLNWDKSNAILVCHALTGDAHAAGWHEGDRKPGWWDIIIGPGKALDTRKYFIICSNVIGGCKGSTGPSSINPDTGESYGLDFPVVTIKDMVNAQKKLIDYLGISKLLAVIGGSMGGLQVLQWSVSYPDMVKKAIPIATAGYSTPQQIAFNEVGRIAIVSDPNWNSGNYYGEKEPTHGLALARMIGHITYLSDDSMHQKFGRRLQDKNEYEFDFSREFEVESYLHYQGLTFTERFDANSYLYLTKAIDYFDLTENNSLAEGLKNVEAKFLVISFTSDWLYPPYQLREIVMALSANNADVTYREIESNYGHDSFLLESGQLNYVLNNFLSHTYVSDIMIEDIATIKEGISIDEAARVMFEKEITHLPLVSSDSKLVGLVTSWDISKSIALKSDNLEEIMTKNVVTARPDEPIEKAAEKMESKDISALPVIDKDRRVIGMVTSEDISRLIEEF
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MB213_DANRE
Sequence: MTNCTDEDLDNYLLNQVDLRHRQVSKCVEDVQKIIKDLTTEVSSKDARFQSIANAGVHNASLKDQPALMSKWSALLRGRCAYNPAIQVLSPTLYLISVPLQGLMGYKERRTRQWRYYTLTGSRLLSPVREPEKLHQWLELESFVNPSQEWHDARMTIEGDIVPAKVVNVFKDLLETSIKTRGLTNKVSVLESVGTAVRVAVETSEAQIEVKLVPTVELMNYWPKRARWPRLFRRWPSTERARCIKSFGFNLMASSNYHWLLSFSRAEQVLLSNIDEDGGCRRKCYRVVRQLKEDGWCPGSKPVITAFHLQTLLFWTCEKYPCTRDWKDFRGCVLRLVQKLHKCVSQHYLRHYFIRSHNLLKYSNTNELDEVAKKINHFLENPGTYIH
What are the official names of this protein?
Protein mab-21-like 3.
What is the protein family that this protein belongs to?
Belongs to the mab-21 family.
Protein: NUON_PSYA2
Sequence: MNDFTMNDLMGLLPYAPIIAVVITVLVVMIAITMKRSHMVTGTISVVGLNIGLFILLGQMAGIIDSGSLVPAAEQLFVIDNFAQFNMVIIFICALACCTLSYAYLADLKDHKEELYLLMLLSTVGALLMVCAQHLASFFMSLEMLSIPLYGMLSYTYMRTRSLESGLKYLVLSATASATLLMGMAFIYAEVGSLAFKPISLTLADTFESPLLILGAAMMMFGIAFKLSAAPFHIWTPDVYEGAPAPIATYLASVSKVAMMALAVRFLIDTSLLALPSVQMLLMVMATLSILLGNLLAVRQTSLKRLLGYSSIAHMGYVLIVIVSIGSAADSISSMYMAIYAFTSIGAFGVVTLMSSPYRLSGEADELTHYQGLFWRRPVLTAVMTIMMLSLAGIPLTAGFITKLFAILAAVQGTNWFLAAMIILGSAIGLFYYLRVLLTLFKRPKQFIEFDVSKQWGLRTGGIMVIAVTAIIVFFGVLPNSMIEWASLARIW
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y5069_DICDI
Sequence: MTPHDEEVDSSD
What are the official names of this protein?
Putative uncharacterized protein DDB_G0294150.
Protein: RNY_BACSU
Sequence: MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQILEDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKHEGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIILERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQDGRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQNVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATKYKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEEISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVTVIRETRAVEYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.  Initiates the decay of all SAM-dependent riboswitches, such as yitJ riboswitch.  Involved in processing of the gapA operon mRNA, it cleaves between cggR and gapA (PubMed:19193632).  Is also the decay-initiating endonuclease for rpsO mRNA.  Involved in degradation of type I toxin-antitoxin system bsrG/SR4 RNAs and a minor role in degradation of type I toxin-antitoxin system bsrE/SR5 degradation (PubMed:22229825, PubMed:26940229).
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Dispersed along membrane with a few foci at septation sites and cell poles; in the absence of dynA fewer foci are seen, in the absence of minJ no foci are seen.
Protein: ATP6_SALTR
Sequence: RNQPTAALGHLLPEGTPVPLIPVLIIIETISLFIRPLALGVRLTANLTAGHLLIQLIATAAFVLLPMMPTVAILTSIVLFLLTLLEIAVAMIQAYVFVLLLSLYL
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL24E_METMA
Sequence: MEQRKCYFCGQMLEPGTGKLYIKKDGSTYFMCSSKCMSNFALGRLPRRTEWTEKGKIQLKKA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
Protein: SECD_RICBR
Sequence: MQNLPKWKIFLSIICTIFAVICALPNFTQVKSKYLPHDSVNLGLDLRGGAHLLLDVDFDTYLNDTMENLADTLRKSFREDKIGYKNLLVKQNNIQLELRSQEELKPLKRIISKIDPEINVEANDNRIKLSYSESRLSELLNKVVDQSIEIVRMRVDSTGTKEPILQKQGDRHILLQVPGEEDPTYLKNILGKTAKLIFHLVDENANVEEAVKGHVPMGSMLVQGDRMGYLVVKKKAILGGDSLTTAAASFDQNSQAVVSFSFNSLGSKLFGEVTKNNVGKHLAIVLDNKLLSAPTINQPIMGGSGIISGDFTVESANELALLLRAGSLPAPLKIIEERSIGPNLGADSIESGKKAGIIGFAAVCIFMVWSYGLLGLFANIALSLAMLYVLALLSLFQATLTLPGIAGIILTMGMAVDANVLIYERIKEELNKGTSNLYAIKTGFESAFATILDSNLTTLIVAFLLYIFGVGAIKGFAVALTIGIISSMFSAIIITKLLIDIWVKYFKPKKLGLV
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEF_PELPB
Sequence: MKKDLLELFDNSFPDRDYTIEIVNAEFTSVCPKTGLPDFGTITIRYVPDKSCIELKSLKYYFLEFRNAGIFYENITNRILDDLVTLLQPRSLSVITEWRARGGITETVSVNYSQTL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHAJ_AERCA
Sequence: MSAQSLEVGQKARLSKRFGAAEVAAFAALSEDFNPLHLDPAFAATTAFERPIVHGMLLASLFSGLLGQQLPGKGSIYLGQSLSFKLPVFVGDEVTAEVEVTALREDKPIATLTTRIFTQGGALAVTGEAVVKLP
What is the function of this protein?
Catalyzes the hydration of trans-2-enoyl-CoA with a chain-length of 4-6 carbon atoms, forming the corresponding (3R)-3-hydroxyacyl-CoA.
What are the official names of this protein?
(R)-specific enoyl-CoA hydratase.
Protein: HISZ_CALS4
Sequence: MIYLPDGVQDFLPEEYEFKRNIEDKFREVFKSFGYKEIMPPTFEYSENFSHLFDENSMYRFFDKKGNILALRPDVTAQIARIVSTKLEGRYPLKLCYVANVYRYEDTQVGKMREFTQAGVELIGTNHEESDAEVIALSIEALKSTGLKDFKIDIGHAEVFGSIVRNLNLGNEDVNLLRELLEQKNQSAIEDFIKQKEIKREEAKLLRELPLLFGGEEILEKLKKENFKETEGVLEYLDRVYKILEDFGMKEYISFDLGMVQNLNYYTGIIFRGFVKGLGYAICTGGRYDKLLKIYGKDLPATGFAISVERVMLALQRQSKGEWVKPRRVLVRYKEEERRRAYEKANVLRKEGNVVEMYTFKRCENIDLKSFDEVVDVGE
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFMAJ_PESFW
Sequence: MVNGNITFDDYLGLQQCLVEWADSYDSKDWSRLRKCIAPTLRIDYRSFLDKLWEAMPAEEFIAMISDKAVLGDPLLMTQHFIGGTKWEKISDTEVVGVHQLRVPHQRYTDETRSTVAVKGHAHSTNTHWYRKVNGEWKFAGLCPEIRWGEFDFDKVFASGREAFGTEDTAAEGISAKHQQQQHGRVTVSAV
What is the function of this protein?
Scytalone dehydratase involved the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment forming a dark layer in the conidial wall that protects the conidia from UV radiations (PubMed:28517364).  The first step of the pathway is the production of the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN or T4HN) by the polyketide synthase PfmaE though condensation of acetyl-CoA with malonyl-CoA.  T4HN is not stable and easily oxidizes into the stable form flaviolin (PubMed:28517364).  T4HN is also substrate of the hydroxynaphthalene reductase PfmaG to yield scytalone (PubMed:28517364).  The scytalone dehydratase PfmaJ then reduces scytalone to 1,3,8-THN (PubMed:31116900).  1,3,8-THN is then substrate of the hydroxynaphthalene reductase PfmaI to yield vermelone (Probable).  Vermelone is further converted by the multicopper oxidase PfmaD to 1,8-DHN (Probable).  Finally the laccase PFICI_06862 transforms 1,8-DHN to DHN-melanin (Probable).  The roles of the 5-oxoprolinase PfmaA and the proline iminopeptidase PfmaB within the cluster have not been elucidated yet (Probable).
What are the official names of this protein?
Scytalone dehydratase PfmaJ, Conidial pigment biosynthesis protein J.
What is the protein family that this protein belongs to?
Belongs to the scytalone dehydratase family.
What are the subcellular locations of this protein?
Endosome.
Protein: PAFA_KINRD
Sequence: MDRRIFGLETEFGVTCAFEGQRKLSPDEVARYLFRKVVSWGRSSNVFLKNGARLYLDVGSHPEYATPECDDVRQLVVHDRAGERTLEGLLTDAERRLEEEGIAGEVFLFKNNTDSAGNSYGCHENYLVSRHGEFGKLSDVLIPFLVSRQLIVGAGKVVQTPRGAVYSLSQRADHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTTMLKLGATDLVLRMVEEGVVLREMTMENPIRAIREISHDMTGRKPVRLANGREASALEIQEEYLEKAKEFVESRGLQTPTIKRVLDLWERALRAVATQDFSLVDREVDWVIKKKLLDRYMAKHDLPLTSPRIARLDLAYHDIHRKRGLHYMLAERGMAERVCSDIEVFEALSVPPQTTRAKLRGDFVRAAQEKRRDFTVDWVHLKLNDQAQRTVLCKDPFKAVDDRVERLIDSM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: CLPB_STAAR
Sequence: MDINKMTYAVQSALQQAVELSQQHKLQNIEIEAILSAALNESESLYKSILERANIEVDQLNKAYEDKLNTYASVEGDNIQYGQYISQQANQLITKAESYMKEYEDEYISMEHILRSAMDIDQTTKHYINNKVEVIKEIIKKVRGGNHVTSQNPEVNYEALAKYGRDLVEEVRQGKMDPVIGRDEEIRNTIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVKKDVPESLLDKTVFELDLSALVAGAKYRGEFEERLKAVLKEVKESDGRIILFIDEIHMLVGAGKTDGAMDAGNMLKPMLARGELHCIGATTLNEYREYIEKDSALERRFQKVAVSEPDVEDTISILRGLKERYEVYHGVRIQDRALVAAAELSDRYITDRFLPDKAIDLVDQACATIRTEMGSNPTELDQVNRRVMQLEIEESALKNESDNASKQRLQELQEELANEKEKQAALQSRVESEKEKIANLQEKRAQLDESRQALEDAQTNNNLEKAAELQYGTIPQLEKELRELEDNFQDEQGEDSDRMIREVVTDEEIGDIVSQWTGIPVSKLVETEREKLLHLSDILHKRVVGQDKAVDLVSDAVVRARAGIKDPNRPIGSFLFLGPTGVGKTELAKSLAASLFDSEKHMIRIDMSEYMEKHAVSRLIGAPPGYIGHDEGGQLTEAVRRNPYSVILLDEVEKAHTDVFNVLLQILDEGRLTDSKGRSVDFKNTIIIMTSNIGSQVLLENVKETGEITESTEKAVMTSLNAYFKPEILNRMDDIVLFKPLSIDDMSMIVDKILTQLNIRLLEQRISIEVSDDAKAWLGQEAYEPQYGARPLKRFVQRQIETPLARMMIKEGFPEGTTIKVNLNSDNNLTFNVEKIHE
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1728_ALISL
Sequence: MPAFDIVSEVDNVELKNAVDNATRELATRFDFRGVDASFELKGENIKIKAEDDFQLTQLVDILRGNLAKRGVDARSMDVKDAVHSGKNFYQDIDFKQGIDPLISKKLVKEIKASKVKVQAAIQGEQLRITGKNRDDLQAAMAIVREGDFGQPFQFTNFRD
What are the official names of this protein?
UPF0234 protein VSAL_I1728.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.