PharMolix/UniProtQA huggingface dataset:
Protein: MINE_PROM1
Sequence: MAMTLRDIINKLLRRQPASASTARERLQLVLAHDRSDLSTELLDQMRKEILEVVAKYVEIDVDEGAVSLETEDRMTALVANLPIKRTITGQIQLKEPKNQSELDSPETEGTDQKS
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: RL1_BACMK
Sequence: MAKRGKKYVEAAKLVDRASAYSATEAVELVKKTNTAKFDATVEAAFRLGVDPKKADQQIRGAVVLPHGTGKVQRVLVFAKGEKAKEAEAAGAEFVGDADYIGKIQKGWFDFDVVVATPDMMGEVGKLGRVLGPKGLMPNPKTGTVTFDVTKAVNEIKAGKVEYRVDKAGNIHVPIGKVSFEDAKLVENFKTIADTLQKAKPAAAKGTYMKNATVASTMGPGVRVDVSTLA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: CREB3_MOUSE
Sequence: MDPGGQDLLALDPGDQDLLGFLLEESGDLWAATEPDVKASLDLELSPSENSVQELSDWEVEDLLSSLLSPSVSRDVLGSSSSSILHDHNYSLPQEHVSIDLGECEMISCRGRRELTGLAGSTFPFADTESFEKEGFHVTPLPGEERAAEQEMSRLILTEEEKKLLEKEGLTLPSTLPLTKVEEQVLKRVRRKIRNKRAAQESRKKKKVYVVGLESRVLKYTAQNRELQNKVQRLEEQNLSLLDQLRKLQAMVIEIANKTSSGSTCVLVLVFSFCLLLVPAMYSSDARGSVPAEYVVLHRKLRALPSEDDHQPKPSALSSELPMDSTHQSLDSSEHMFLVSSNFSCVLYHAPQAEQPLHWPLWDLSSEMLFSDSNLLLQANLSESEGWQPNHSPSLVIFQGRYSG
What is the function of this protein?
This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response.  Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many promoters to activate transcription of the genes.  Binds to the unfolded protein response element (UPRE) consensus sequences sites.  Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3').
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 3, CREB-3, cAMP-responsive element-binding protein 3, Transcription factor LZIP.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus. Nucleus. Cytoplasm. Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia. Colocalizes with DCSTAMP in the ER membrane of immature dendritic cell (DC). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane. SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3]: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB).
Protein: ASTD_KLEP7
Sequence: MSLWINGEWRPGRGPGFSKQDPVNLKVVWQGEAADAGQVAEAVAAARQAFPSWARLPFAARQAIVEKFAALLEASKAELTAVIGAETGKPRWEAAGEVTAMINKVAISVKAYHVRTGEQHSDLPDGAATLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPRSGEAVVKLWQQAGLPAGVLNLVQGGRETGEALSGQADIDGLLFTGSSTTGFHLHRQLAGQPQKILALEMGGNNPLIVDDPRDVDAVVHLTIQSAFITAGQRCTCARRLLVRRGEAGDAFLSRLVTVSQRLIPAAWDAEPQPFLGGLISEQAAQKVHQAWLQRVAAGAVTLLEPRLLQAGTSLLTPGIVDMSDVANVEDEEVFGPLLGVWRYDTFEEAIALANATRFGLSCGLISPEREKFDRLLLEARAGIVNWNKPLTGAASTAPFGGTGASGNHRPGAWYAADYCAWPMASLESPTLTLPASLSPGLDFLAGEAS
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: RL15_THERP
Sequence: MKLHELKPAPGSRRPKTRVGRGIAAGKGKTAGRGTKGQKARSKVRPGFEGGQNPLYLRLGRMRGFKNPFKIVYEVVNVGRLNELPYEGVITPDVLRSFRLVRENGAPVKILGDGDVTRPLHVQAHAFSESARQKILAAGGTVEVIS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: DUT_WOLPM
Sequence: MQRSKIKVEIKRLSHGEDLSLPCYATTQSAGMDLYAALNDSAVLNPLERLLVPTGIVIAIPNGFEGQIRPRSGLAAKHGITVLNSPGTIDSDYRGEVKICLINLSNQPYEIKRGDRIAQILISPVSQVIWDDREEFCAEETGRNAGGFGSSGR
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: FZO_DROSI
Sequence: SSMEPEMEQKVKDQHMERCVNLLVDELGVYSTAQEAWERIYHVSALEALHIRNGHIKNPSAQTKERYQEFLRFENDFSNCLAVSALKTKFGPHLLSAQKILNQLKSTLISPFIEKVSRLIDENKERRANLNAEIEEWELEMQDEREDLQYCFEELTEMTQRLGRCVLNDQIKTLIPSAVLSFSHPFHPEFPAQIGQYQRSLCAHLDNLLEDRVLQCLSIPLQRKILDMEKELGLQITEKSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNLPLHSSPFRTQKLRNGHKKCLPLPPLVHGNHWQMLESLVKSKGSLGTVLLGAMAIRSFNWPIVMILGGLVGSFYMYEYAAWTTAAQERSFKSQYSRLLQQRLRTDVQQTVSGFELQLRQHLAKVRNCWEAQSNETLNDLNVRTAELTKQIQSMEVLQLSLKKFRDKGQLLASRL
What is the function of this protein?
Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis.  In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission.  Essential for fertility (By similarity).
What are the official names of this protein?
Transmembrane GTPase fzo, Protein fuzzy onions.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: THIE1_STRPN
Sequence: MFHKELLKLYFICGTTTCQGKNLYTVVEEALKGGITLFQFREKGEGALEGLEKLELAIQIKELCKKYNVPFIVNDDIDLAMEIDADGVHVGQDDIGVDEIRKLMPDKIIGLSIRNEEEFQQSKVEYVDYVGVGPVFGTQSKDDAGGTIGYEGLELMRKLLPQMPLVAIGGIQTKHIKDIIKTNMDGVSIISAISYAKNIEKTVREMSEQ
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase 1, TP synthase 1, TPS 1, Thiamine-phosphate pyrophosphorylase 1, TMP pyrophosphorylase 1, TMP-PPase 1.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: NU4LM_PHOHO
Sequence: MSMVYFNIFMAFTVSFVGLLMYRSHLMSSLLCLEGMMLSLFVMMSMTILNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: F16A1_ALBFT
Sequence: MPLTYRSTLTQFLIEERRRFPNASGDFNALILDVALACRAIARAVALGELGGAMGNHAAETGGSVNVQGETQKKLDVLSNEVFIRRTEWAGNLAGMASEEMELPYQIPQQYPRGKYMLVFDPLDGSSNIDVNVCVGSIFSVLRAPQDALDSGRDLNEADFLQAGRQQVAAGYAVYGPSTLLVLTVGNGVNGFTLDPNLGEFMLTHPKMQIPPETHEFAINASNSRFWQAPVKRYVDECLAGQTGPRGKDFNMRWIASMVAEAHRILMRGGVFMYPRDNKDPAKPGRLRLLYEANPVGMLMEQAGGRASTGELPMLDVQPTSLHQRIGLVFGSKNEVERIERYHAEPVQAEPSNPLFAERSLFRS
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1 1, FBPase class 1 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPRT_METM5
Sequence: MSRLLEESLKTCPIVKRGEYHYFIHPISDGVPLVEPELLRDISTRVIKMIDTEVDKIVTAEAMGIPIVTAVSIATDIPYVIMRKREYLLEGEIPVHQETGYSKGELYLNGINKGDKVVILDDVISTGGTLVAIINALKRAGADIRDVLCIIDRGNGQNIVEEKTGYKVKTLVKIEVVDGKVQILK
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
What are the official names of this protein?
Hypoxanthine/guanine phosphoribosyltransferase, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOE_UREPA
Sequence: MSRQLVDIAYNAIKNNKIYNKKPFTFDDIINEIVKNSNVNLVEVNSQLGVLYTTLIQDTRFISIGDLEWNLRERLSLDEITKINNAMYEVGLYKDSDREEDEHEIVKNDKLTQSKEQEESDEVSSLSDFVGYEDEDEEFKNNNTSNKDEIEDEEELEEEE
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity).
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: HUTH_XANCP
Sequence: MSASVVLQPGQVTLAQWRALYRGAEVTLDPACAQAVLRSAQTVEAIVARGEPVYGVNTGFGKLASVRIERDDLQTLQRNIVLSHAAGVGDPTPVPVVRLMMALKLTSLAQGASGIQPDTLALLEAMLRQGITPVVPCQGSVGASGDLAPLSHLAAVMIGVGEAFVGDQRLPAADALARAQLQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDARIHALRGQPGQIATAAALRALMAESAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQAARTLEIEANGVSDNPLVFSDTGEALSGGNFHAEPVAFAADMLALAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQCAYPASVDSIPTSANQEDHVSMAAHGARRLLAMADNAAHVIGIELLAAVQGCDFHAPLRSSAALEAARALLRAQVPTLQDDRYFHPDMLAASALVRSGALATAVGIVLPGVELSA
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXP3_MOUSE
Sequence: MPNPRPAKPMAPSLALGPSPGVLPSWKTAPKGSELLGTRGSGGPFQGRDLRSGAHTSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHAQTPVLQVRPLDNPAMISLPPPSAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHLAGKMALAKAPSVASMDKSSCCIVATSTQGSVLPAWSAPREAPDGGLFAVRRHLWGSHGNSSFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQRPNKCSNPCP
What is the function of this protein?
Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:22813742).  Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells.  Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases.  The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG).  Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681).  Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (By similarity).  Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532).  Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049).  Inhibits the transcriptional activator activity of RORA (By similarity).  Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (PubMed:19696312).
What are the official names of this protein?
Forkhead box protein P3, Scurfin.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg) (By similarity). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells.
Protein: MNMG_PSET1
Sequence: MIFHENFDVIVVGGGHAGTEAALAAARMGMNTLLLTHNMDTLGQMSCNPAIGGIGKGHLVKEIDALGGAMAQAIDKGGIQFRTLNSSKGPAVRATRAQADRALYKAAIQTTLQNQDNLKIFQQSCDDLIVENDRVTGVVTQMGLRFSAPSVVLTVGTFLGGQIHIGLENFKGGRAGDPPSIALADRLRELPFRVDRLKTGTPPRIDARTVDFSKMQEQAGDTPIPVFSFMGKPSDHPQQIPCYITFTNEKTHDVIRKNLHRSPMYGGVIEGIGPRYCPSIEDKIVRFADKDKHQIFVEPEGLTSYELYPNGISTSLPFDVQIEIVQSITGFENAHICRPGYAIEYDFFDPRDLKRSLETKFIDGLFFAGQINGTTGYEEAGAQGLIAGMNAALKVQGKESWTPRRDEAYVGVLIDDLTTLGTKEPYRMFTSRAEYRLLLREDNADIRLTEKGRELGLVNDERWQAYNEKMEVIAKEKQRIKDTWIHKDHTMIDQVNALLKTPLTREASLEELLRRPEIRYNDLMAIDGLGSEFTNQAALEQVEIHTKYAGYIVRQQDEINKQLRHEQTILPKEFDYKTVSGLSNEVVAKLIDARPDTIGQASRISGITPAAISLLLVYLKKQGLLRKSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD2_PSEPG
Sequence: MNALTSLKLIDGKATAARVLAEVREQVQELRQGGVQPGLVVVLVGADAASQVYVRNKVLRAEEVGIRSQEHRLPADTTQAHLLTLIDRLNRDPEVNGILVQLPLPAHIDEHCVLQAINPLKDVDGFHSENVGGLAQGRDVLTPCTPSGCMRLLRDACGELRGKHAVVVGRSNIVGKPMAALLLQADCTVTVVHSRSRDLPALCRQADILVAAVGKPRLIGADCLKPGAVVIDVGINRINEDGQNHLVGDVDFAAALPQVAGITPVPGGVGPMTIAYLMKNTLLALDLQQQAAHQERTACLSPC
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 2.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: END4_VIBCM
Sequence: MYEKLIGAHVSASGGVELAPVRAHEIGANAFALFTKNQRQWAAKPLEASSIRAFKANCKKWGFGSEAILPHDSYLINLGAPEPEKLDKSRAAFVDEMLRCDQLGLTLLNFHPGSHLQQVSEEACLATIAESINLAHRQVPNVIAVIENTAGQGSNLGWRFEHLAAIIDQVEDKERVGVCLDTCHTFAAGYDLRTKAACDETFAEFERVVGMHYLRAMHINDSKGKLASRVDRHHSLGMGEIGWECFEYIAQDARFNGIPLILETIDPDIWATEIATLRKFSTQKEN
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: JMJ32_ARATH
Sequence: MAKEIENLWREVRELSLGTKIDRFDSQPSPVKFLRNYVSQSKPCVISKAITHWPALKLWSDPAYLTGALSDDVVSLHLTPNGCADAVTGDSDLCFASAHVEKVLFPEALKVVQSSCKGLKVGYLQQQNDCFRTEYSTVALDCDGDIEWATEAFGCSPEAVNLWIGTDDSVTSFHKDHYENLYAVVSGEKHFLLLPPTDVHRLYIEQYPAANYSYHRDTDAFKLEVEEPVRHVPWSSVDPYPSPEKEASERLKFPLFFDGPKPFHCTVKAGEVLYLPSMWFHHVSQTPGDGGYTIAVNYWYDMQFDIKYAYFNFLQSLLYKSSSLNPVLSWREDEDSESSDAEIAP
What is the function of this protein?
Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3 with a specific activity for H3K27me3 and H3K27me2, and involved in the regulation of gene expression (PubMed:25267112, PubMed:33324437).  No activity on H3K27me1 (PubMed:25267112).  Together with JMJ30, regulates the flowering-repressor FLOWERING LOCUS C (FLC) locus by removing the repressive histone modification H3 lysine 27 trimethylation (H3K27me3), especially at elevated temperatures (e. g.  29 degrees Celsius), thus preventing extreme precocious flowering (PubMed:25267112).  JMJ30 and JMJ32 are regulators involved in the integration of abscisic acid (ABA) and brassinosteroids (BR) signaling pathways (PubMed:33324437).  Together with JMJ30, controls ABA-mediated growth arrest during the post-germination stage in unfavorable conditions, and responses to ABA during root development, via the removal of repressive histone mark (H3K27me3) from the SnRK2. 8 promoter, thus promoting SnRK2. 8 expression and subsequent kinase-dependent ABI3 activation (PubMed:30859592, PubMed:30983495).  In addition, removes the repressive histone marks (H3K27me3) from the BZR1 locus in response to stress and ABA, thus activating the BR signaling pathway which, in turn, inhibits the ABA signaling pathway (PubMed:33324437).
What are the official names of this protein?
Lysine-specific demethylase JMJ32, Jumonji domain-containing protein 32, AtJMJ32, Protein JUMONJI 32, Lysine-specific histone demethylase JMJ32, [histone H3]-trimethyl-L-lysine(27) monodemethylase JMJ32.
What is the protein family that this protein belongs to?
Belongs to the JARID1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Predominantly localized in the nucleus.
Protein: NHAA_FRATH
Sequence: MGASQKNQELIGGLILFSAALLAIVVNNSPLASYYAMLETINVKLGIENLVIDKNLMHWINDGLMAIYFLYIGLEIKREIIVGTLSKLSNIITPAIAAFAGLAMPSLIYLSINHDIKVINGWAIPSATDIAFTLGILALLGTRVPAKLKLLVITIAIFDDIAAIAIIAIFYTKSLSLLSLSLGTLFILAMIICNRIFKINRSSVYVVLGFFAWFCTIKSGVHATLAGFTTALCIPFRENDKDSPANFMEDSLHPWIIYFILPVFAFANAGISFSGISFSILFEPITLGIIWGLFVGKQLGIFSILAVFKKLKWFKLGESFSNLQLYGISLLCGIGFTMSLFIGVLAFNDTHLLNAIKIGVVVGSVLSGFFGYIVLRFIVTNPS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VL2_HPV42
Sequence: MPPQRSRRRKRASATQLYQTCKASGTCPPDVIPKVEGTTLADKILQWGSLGVFFGGLGIGTGAGTGGRTGYVPLGTRPPVIAEPGPAVRPPIAVDTVGPSDPSIVSLLEESSVIDAGITVPDITSHGGFNITTSTGGPASTPAILDISPPTNTIRVTTTTSTNPLYIDPFTLQPPLPAEVNGRLLISTPTITPHSYEEIPMDTFVVSTDTTNTFTSTPIPGPRSSARLGLYSRATQQRPVTTSAFLTSPARLVTYDNPAYEGLTEDTLVFEHPSIHTAPDPDFMDIVALHRPMLSSKQGSVRVSRIGQRLSMQTRRGTRFGSRVHFFHDLSPITHSSETIELQPLSASSVSAASNINDGLFDIYVDTSDVNVTNTTSSIPMHGFATPRLSTTSFPTLPSMSTHSANTTIPFSFPATVHVGPDLSVVDHPWDSTPTSVMPQGNFVMVSGWDFILHPSYFWRRRRKPVPYFFADVRVAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: SYC_BRUAB
Sequence: MPDTTPQLRLYNTLTRTKEAFAPIDAKNVRMYVCGPTVYDFAHIGNARPVIVFDVLFRLLRHVYGAQHVTYARNITDVDDKINARAARDYPDLPFNEAIRKVTESTNAQFQADVTALGNLQPTVQPRATEHMDEMRAMIDRLVQRGVAYVAQDHVLFSPSAMNARKGPRYGALARRSLDEMLAGARVDVASYKRDEMDFVLWKPSKKGEPGWPSPAGIETLGRPGWHIECSAMSMAKLLEPFGGGLKCDDPERNQFDIHGGGIDLVFPHHENEIAQSCCALGTERMANIWMHNGFLQVEGQKMSKSLGNFITIRDVLNDGLPQLGEWGDNTVRDHWAGLAARLSMLQTHYREPINWTAQRLAESADELHRWYGLLRDEGFGAPEKLSHASAVAAALCDDLNSWAAITALRQAFKVRDVAALGEGMALMGLLDPYFVTASDVPIFARADVDASAIAARIAERLNFINAKNWAEADRIRDELLQEGVQLKDSKDPATGERITTWDVVG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIXA_ECOLI
Sequence: MKIITCYKCVPDEQDIAVNNADGSLDFSKADAKISQYDLNAIEAACQLKQQAAEAQVTALSVGGKALTNAKGRKDVLSRGPDELIVVIDDQFEQALPQQTASALAAAAQKAGFDLILCGDGSSDLYAQQVGLLVGEILNIPAVNGVSKIISLTADTLTVERELEDETETLSIPLPAVVAVSTDINSPQIPSMKAILGAAKKPVQVWSAADIGFNAEAAWSEQQVAAPKQRERQRIVIEGDGEEQIAAFAENLRKVI
What is the function of this protein?
Required for anaerobic carnitine reduction.  May bring reductant to CaiA.
What are the official names of this protein?
Protein FixA.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: RL18_SYNP2
Sequence: MKATRKQLTQRRHFRIRRRVEGTGDRPRLAVFRSHKHIYAQVIDDEKQHTLVAASTLDKDLKGELASGGNISASTAVGNLIAKRALEKGITKVVFDRGGNLYHGRVKALADAAREAGLDF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: UBCX_YEAST
Sequence: MPNFWILENRRSYTSDTCMSRIVKEYKVILKTLASDDPIANPYRGIIESLNPIDETDLSKWEAIISGPSDTPYENHQFRILIEVPSSYPMNPPKISFMQNNILHCNVKSATGEICLNILKPEEWTPVWDLLHCVHAVWRLLREPVCDSPLDVDIGNIIRCGDMSAYQGIVKYFLAERERINNH
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Essential for peroxisome biogenesis (By similarity) (PubMed:17550898, PubMed:18644345).  Required for UBC4-independent ubiquitination of PEX5 (PubMed:17550898, PubMed:18644345).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2-21 kDa, E2 ubiquitin-conjugating enzyme PEX4, Peroxin-4, Ubiquitin carrier protein, Ubiquitin-protein ligase.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Peroxisome.