PharMolix/UniProtQA huggingface dataset:
Protein: TMED2_CRIGR
Sequence: DVLVLLAALLATASGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV
What is the function of this protein?
Involved in vesicular protein trafficking.  Mainly functions in the early secretory pathway but also in post-Golgi membranes.  Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side.  In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER.  Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1.  In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place.  Involved in trafficking of G protein-coupled receptors (GPCRs).  Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization.  Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting.  Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus.  May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity).
What are the official names of this protein?
Transmembrane emp24 domain-containing protein 2, COPI-coated vesicle membrane protein p24, p24 family protein beta-1, p24beta1.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway.
Protein: ORR3O_CATAD
Sequence: MHRLALTAQDNLAVAPMLADLAGRYPDIEDPELIRSAPVLAAKGLPPHLLAFLDDFRLREPSALCVISGLDVDQDRLGPTPEHWRDSQIGSRSLNLEIFFLLCGAALGDVFGWATQQDGRIMHDVLPIKGHEHYELGSNSLQHLSWHTEDSFHPCRGDYVALMCLKNPYEAETMVCDAGDLDWPNLDVDALFEPVFTQMPDNSHLPQNTAESTGDPTKDRLRARSFELIKSWNENPVRRAVLYGDRQNPYMALDPYHMKMDDWSERSLEAFQALCEEIEAKMQDVVLHPGDIAFIDNFRAVHGRRSFRARYDGSDRWLKRLNITRNLRGSRAWRPAPDDRVIY
What is the function of this protein?
Alpha-ketoglutarate-dependent dioxygenase that in vitro catalyzes the regio- and stereoselective hydroxylation of L-ornithine and L-arginine, leading to (3S)-3-hydroxy-L-ornithine and (3S)-3-hydroxy-L-arginine, respectively.  Cannot use L-lysine, D-ornithine, or D-arginine as substrate.
What are the official names of this protein?
L-ornithine/L-arginine 3-hydroxylase, Alpha-ketoglutarate-dependent dioxygenase, L-ornithine/L-arginine hydroxylase, ODO.
What is the protein family that this protein belongs to?
Belongs to the clavaminate synthase family.
Protein: CDUB2_CHLTJ
Sequence: MEPIHNPPPQTCSYSRPSTTYTSFKDASCGTKVTRIIIALFLIVISCGLILCAYTFRDLLDADYSAQEGPQQATKLLQQLDKVLTGPPLPIWDNEHLFQFSCLMQNKHRRVLPIDICNPLTKFNFLEYICNCLMTKQSVNVNETDMCELFCPPTCTPENYRRLLCTSSVFPFVMWHDPSADTQEAMLTKMDQTMSSGRVGNSHWVLVIVDIEHRCVTFFDSFYNYIASPQQMREQLEGLAASLGAIYPKEGGSDSDQEELLSPFQVRIGSTVKVQSPGEFTCGAWCCQFLAWYLENPDFDLEEKVPTNPSERRALLADFISTTEQAMSRYSSLSWPTTD
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  This protease possesses deubiquitinating and deneddylating activities (By similarity).
What are the official names of this protein?
Deubiquitinase and deneddylase Dub2, ChlaDub2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C48 family.
What are the subcellular locations of this protein?
Secreted. Host cell. Membrane; Single-pass membrane protein. Note=Secreted, and delivered into the host cell.
Protein: CIAO1_CANGA
Sequence: MPLQLAKSLKLHNDKVWSIDFEPVRGLLATGSTDRAIKVLQLKNGKENLLDVLDDTVHKKAVRSVAWRPHSDLLAAGSFDSTISIWTQSDLDLEEGAKLEMELLAIIEGHENEVKGISWSQDGCLLATCSRDKSVWIWETDEAGEEYECISVLQEHSQDVKHVVWHTKHNLLASSSYDDTVRIWKDYDDDWECAAVLTGHEGTIWCSDFSKEEDPIRLCSGSDDSTVRVWKYIGDDEDDQQEWVCESTLPNAHRSQIYGVAWSPSGRIASVGADGVLAVYKEKQNDSEVSEWEISATYKAAHTVYEINTVKWVNIDGKEMLITAGDDGRVNLWNYQD
What is the function of this protein?
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery.  Required for the maturation of extramitochondrial Fe/S proteins.
What are the official names of this protein?
Probable cytosolic iron-sulfur protein assembly protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CIA1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Preferentially localized to the nucleus.
Protein: GUAA_THEAB
Sequence: MNTVVVLDYGSQYTQLIVRRVREKGYYAELLPWDASKEEVQNLNPAAIILSGGPASVFEKDAPFVPDYILELNIPILGICYGLQSLVHKFGGIVEKSPKREFGHAVLKVKDDPLFEGLPKEFDVWMSHSDRVEKLPEGFLVIGESENSPYAAIRNKDGTIYGVQFHPEVTHTSFGDKILENFVSKVAKMEKNWKMTDFIEEKINEIRKVVGNDKVILGLSGGVDSSVVALLLDKAIGKNSIPIFVDTGLLRLNERQEVEENFRKLGIDIVVVDAKERFLSNLKGVEDPEEKRKIIGHTFIDVFYEASMKLLEKHGNIKYLAQGTLYPDIIESKVSERKAAAKIKTHHNVGGLPEKLPFKIIEPFRYLFKDEVRKIGKILGLPDEMINRHPFPGPGLAVRIIGEVTNEAIKILQHADHIFIEELKKNDLYDKVWQAFAVFLPIRSVGVMGDYRTYDNVIALRAVNSFDGMTADWSKLPHEFLNKVAKRIVNEVDGVNRVVYDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RT106_ASPNC
Sequence: MAFATINSSVPSSIPAIEDAFAAEPALKKRVYDAIAHTPQHGLLFEDIAKYTSSLLARTATAPVRPVEVVSDGPAMKKRKLQNGNATSAQSSGDLKSDTSLQFYMQDVSFAVPQRKKLTLEVTAGFLRARNQTSKEVEFGVPLDNIQHVLCLPVPEKNQRQFNFCIIPQYADGVNSPPEGVAAPDAIVWTVNDGPPKAAFSGNGQQLGTDNEETADKLVQRILNDSLPRTKVVRPDEREFVSAMPEAHRKGEKAFHVKAFRGSKEGYLFLLSTGILFGFKKPLVFFAFENVDSISYTSVLQRTFNLNVVARPTSSEETQEFEFSMIDQADFSGIDGYIKKHGLQDASLAEARRAKRYNVNGAKGEDEAAANEEGAVEEESELQKAQRELEDQEDEDEEDYDPGSDSDSDGSGSSSEEDDDDDEEDDEGDMEEDDEEGDRNLVAEELGSEAEDVPAEEL
What is the function of this protein?
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing.  Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA.  Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
What are the official names of this protein?
Histone chaperone rtt106.
What is the protein family that this protein belongs to?
Belongs to the RTT106 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: UVRC_LISMF
Sequence: MSSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKILKNRVRSYFSGTHDSKTQRLVQEIVDFEYIVTSSNVEALLLEINLIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVKKDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVCLYYHLGQCLAPCVFDVEASKYKEMQDEIVTFLNGGYKTVKNDLMKKMQEAAENMEFEKAGEFRDQINAIETTMEKQKMTMNDFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKANHIPPKEIYLPDDVDSEAVQAVVPDTKIIVPQRGNKKDLVKLAYKNAKIALNEKFMLLERNEERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAMVTFLDGKPSKNDYRKYKIKTVEGPDDYATMREVIRRRYWRVLKEELPMPDLILIDGGKGQIDSAKDVLTNELGLDIPVAGLAKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSILDGIPGVGPGRKKKLLKHFGSMKKLKEASVEEIKEAGVPLNVAEEVHKHITAFNEKAKNTEQK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_HELPG
Sequence: MQKIGIYPGTFDPVTNGHIDIIHRSSELFEKLIVAVAHSSAKNPMFSLKERLKMMQLATKSFKNVECVAFEGLLANLAKEYHCKVLVRGLRVVSDFEYELQMGYANKSLNHELETLYFMPTLQNAFISSSIVRSIIAHKGDASHLVPKEIYPLISKA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPI_CERS4
Sequence: MIGRLNHVAIAVPDLEAAAAQYRNTLGAEVGAPQDEPDHGVTVIFITLPNTKIELLHPLGEGSPIAGFLEKNPAGGIHHICYEVEDILAARDRLKEAGARVLGSGEPKIGAHGKPVLFLHPKDFNGCLVELEQV
What is the function of this protein?
Promiscuous isomerase that catalyzes epimerization of both ethylmalonyl-CoA and methylmalonyl-CoA.  Has thus a dual role in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R. sphaeroides growth on acetate as sole carbon source.
What are the official names of this protein?
Ethylmalonyl-CoA/methylmalonyl-CoA epimerase.
What is the protein family that this protein belongs to?
Belongs to the methylmalonyl-CoA epimerase family.
Protein: RETNB_MOUSE
Sequence: MKPTLCFLFILVSLFPLIVPGNAQCSFESLVDQRIKEALSRQEPKTISCTSVTSSGRLASCPAGMVVTGCACGYGCGSWDIRNGNTCHCQCSVMDWASARCCRMA
What is the function of this protein?
Probable hormone.
What are the official names of this protein?
Resistin-like beta, Cysteine-rich secreted protein A12-beta, Cysteine-rich secreted protein FIZZ2, RELMbeta.
What is the protein family that this protein belongs to?
Belongs to the resistin/FIZZ family.
What are the subcellular locations of this protein?
Secreted.
Protein: BFD_ECOLI
Sequence: MYVCLCNGISDKKIRQAVRQFSPHSFQQLKKFIPVGNQCGKCVRAAREVMEDELMQLPEFKESA
What is the function of this protein?
Seems to associate with BFR; could be a general redox and/or regulatory component participating in the iron storage mobilization functions of BFR.  Could participate in the release or the delivery of iron from/to bacterioferritin (or other iron complexes).
What are the official names of this protein?
Bacterioferritin-associated ferredoxin.
Protein: RNC_HELMI
Sequence: MKRAPNHPAELARRIGIASEDLATLEMALTHPSFVYENPQAPPEHNQRLEFLGDAVLGLVIGEQLFVRYPTWTEGELSRRRAAVVCEANLADGARRLQLGAWLKLGRGEEASGGREKPSILADALEAVIGAIFLSGGIEAARRFIVDLFGDALANAQNLVSGDNKTAFQEWVQRTGPADIRYCIVDESGPDHDKRFVAAVMVNGTVIADGQGRTKKEAEQQAAGRAMREWAGRKG
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_BRUO2
Sequence: MSDRNPLIDADRRADEDNTLRPQTLDDFVGQAAARANLKVFIEAAKVRGEALDHVLFVGPPGLGKTTLAQIMAKELGVNFRSTSGPVIAKAGDLAALLTNLEERDVLFIDEIHRLSPAVEEILYPAMEDFQLDLIIGEGPAARSVKIDLAKFTLVAATTRLGLLTTPLRDRFGIPVRLNFYTVEELEYIVRRGARIMQMGISSDGAREVARRSRGTPRIAGRLLRRVRDFALVAGADIIDRRIADEALSRLEVDNRGLDQLDRRYLNIIARNFGGGPVGIETIAAGLSEPRDAIEDIIEPYLIQQGFLQRTPRGRVLTAVAWQHLGLPAPAEIIQQSQYGLFMEDE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MECA_LYSSC
Sequence: MDIERVNENTLKLFITYNDIEDRGYSREEIWYNRAKGEQLFWDMIDEVNTEDYFDVEGPIWIHINASEVGLEIIVTRAHILKDGETLDGHSNFDEHKEMFAPFDEVGDDLLSQLTQFGDMDESELFMDTDIYVYKFKDIDELIPVAKRMTDELVDSSLFKYENWYYLVVDFGNADEELNRHDRNAVIKEFLTPSNFTIHRLEEYGEKIMEFNCFETVRKYFA
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: UPL4_ARATH
Sequence: MENRGQKRMEVVEELPADKRACNSQDFRPSTSGSSVQAQANDTNPGHENVDADMDTSSSASPSSRSDEEEQEEQDKEDSDYGSCDSDEEDPRQRVLQDYQRQRSSGDHGKLKSLLLNLTGETDPSGQLSRLTELCEVLSFSTEESLSSVMANMLSPVLVKLAKHENNADIMLLAIRAITYLCDVYPPSVEFLVRHDTIPALCQRLLTIEYLDVAEQCLQALEKISRDEPVACLNAGAIMAVLSFIDFFSTSIQRVAISTVVNICKQLSSESPSPFMDAVPILCTLLQYEDRQLVENVAICLTKIADQASESPAMLDQLCRHGLINESTHLLNLNSRTTLSQPVYNGVIGMLRKLSSGSALAFRTLYELNIGYSLKEIMSTYDISHSVSSTHPINACSNQVHEVLKLVIELLPASPVEDNQLASEKESFLVNQPDLLQQFGRDMLPVMIQVLNSGANVYVSYGCLSAIHKLTCLSKSGDIVELLKNTNMSSVLAGILSRKDHHVIVVALQVAEVLLEKYRDTFLNSFIKEGVFFAIEALLSSDRGQQNQGSADLSQKPVTKEIVKCLCQSFERSLSSSSQTCKIEKDSVYVLATRIKEGFFGPEVFNSEKGLTDVLQNLKNLSVALSELMTVPIDAHVLHDEKFFSIWNQIMERLNGRESVSTFEFIESGVVKSLASYLSNGLYQRKLSKGGPECDSLPFIGKRFEVFTRLLWSDGEATSSLLIQKLQNSLSSLENFPIVLSQFLKQKNSFAAIPNGRCTSYPCLKVRFLKAEGETSLRDYSQDFVTVDPLCYLDAVDQYLWPKVNIEPIDSVEAKDQAIECQSSQLQSTSISCQAESSSPMEIDSESSDASQLQGSQVEDQTQLPGQQNASSSETSSEKEDAVPRLLFRLEGLELDRSLTVYQAILLHKLKSESEATNDSKLSGPHNITYERSAQLGDSRENLFPPGSMEDDEYRPFLSYLFTHRLALRLKGSSHPPYDILFLLKSLEGMNRFLFHLISLERINAFGEGRLENLDDLRVQVRPVPHSEFVSSKLTEKLEQQLRDSFAVSTCGLPPWFNDLMDSCPCLFSFEAKSKYFRLAAFGSQKIRHHPQHLSSSNVHGEARPVTGSLPRKKFLACRENILESAAKMMELYGNQKVVIEVEYSEEVGTGLGPTLEFYTLVSRAFQNPDLGMWRNDCSFIVGKPVEHSGVLASSSGLFPRPWSGTSTTSDVLQKFVLLGTVVAKALQDGRVLDLPLSKAFYKLILGQELSSFDIHFVDPELCKTLVELQALVRRKKLFAEAHGDSGAAKCDLSFHGTKIEDLCLEFALPGYTDYDLAPYSANDMVNLDNLEEYIKGIVNATVCNGIQKQVEAFRSGFNQVFSIEHLRIFNEEELETMLCGECDLFSMNEVLDHIKFDHGYTSSSPPVEYLLQILHEFDREQQRAFLQFVTGSPRLPHGGLASLSPKLTIVRKHGSDSSDTDLPSVMTCANYLKLPPYSSKEKMKEKLIYAITEGQGSFHLS
What is the function of this protein?
Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
E3 ubiquitin-protein ligase UPL4, Ubiquitin-protein ligase 4, HECT-type E3 ubiquitin transferase UPL4.
What is the protein family that this protein belongs to?
Belongs to the UPL family. K-HECT subfamily.
Protein: BPT_SHESR
Sequence: MNSNASNTPIAIGISQIFPCSYLDGQQEQLLVIQEETLDPILFDRLLAIGFRRSGSAIYKPRCPRCSACQPIRLPIKEFTPSKRQKRTLAHNRDLTWRITSEHTEAQYALYEKYIRERHFDGPMFPPSKTQYEQFLFCHWLPPTFIEVYDGNRLLAVAVTDTLSNSLSAIYSYFDPDEERRSLGSLLILLQCRLAKLQDKEFLYLGYQIDANRKMSYKRLYRPYQILTPQGWEYSQVC
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEMA1_LINRU
Sequence: YRIASSSIAKMKTAVFLVGLLFLGLVFADEAAIDSEFDQSIDKRGCIATGSFCTLSKGCCTKNCGWNFKCNPPNQK
What is the function of this protein?
Highly potent toxin against insect sodium channel (Nav) and with less potent activity against mammalian sodium channels (PubMed:29567943).  Potently inhibits inactivation of insect sodium channels of B. germanica (BgNav1) (EC(50)=8. 6 nM), D. melanogaster (DmNav1), and arachnid sodium channel V. destructor (VdNav1) (PubMed:29567943, PubMed:34445875).  Also delays the inactivation of most mammalian Nav channels tested (hNav1. 1/SCN1A; EC(50)=124. 1 nM, rNav1. 2/SCN2A; EC(50)=359. 6 nM, rNav1. 3/SCN3A; EC(50)=135. 4 nM, rNav1. 4/SCN4A; EC(50)=145. 5 nM, hNav1. 5/SCN5A; EC(50)=138. 3 nM, mNav1. 6/SCN8A; EC(50)=240. 4 nM, hNav1. 9/SCN9A; EC(50)=76. 5 nM) (PubMed:29567943, PubMed:34445875).  1 uM is enough to completely inhibits the inactivation, resulting in sustained non-inactivating currents (PubMed:29567943).  In addition, the toxin significantly enhances the recovery from inactivation, and the open state is not required for the toxin to interact with the channel (PubMed:29567943).  In vivo, injection into green crabs (Carcinus maenas at 1 mug/kg) of small doses (1-5 ug/kg) results in slow and fast permanent paralysis, whereas injection of high doses (more than 10 ug/kg) causes death (PubMed:29567943).  Injection into juvenile Blaptica dubia cockroaches results in death or permanent paralysis at doses higher than 7. 1 ug/kg (PubMed:29567943).  Injection into brine shrimp (Artemia salina) stops movement or causes death after 24 hours (EC(50)=0. 3 uM) (PubMed:34445875).  In the rare inherited cardiac arrhythmia Brugada syndrome 1 (BRGDA1), this toxin is able to restore the loss of function by reducing channel inactivation, without affecting activation, by binding to Nav1. 5/SCN5A (PubMed:32850980).
What are the official names of this protein?
Nemertide alpha-1.
What is the protein family that this protein belongs to?
Belongs to the nemertide family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_ECO81
Sequence: MSLSTEATAKIVSEFGRDANDTGSTEVQVALLTAQINHLQGHFAEHKKDHHSRRGLLRMVSQRRKLLDYLKRKDVARYTQLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: PCP_OCEIH
Sequence: MKKILLTGFVPFLDNPINPTEEIVQGLHKKSVNGWEVVGEVLPVDFHVTGDHLVELIHKVQPSAIISLGLAAGRNRITPERIAINCNDGPVDNQGYKPDGEKIISDGPDGYFSSLPIKKMVKELENNGIPAKISNTAGAYLCNHVMYRALHEIEQQKLDIFSGFIHIPASHKLALTNNIPSFAQKDLQRAIEICIGCLD
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLSA_ECO7I
Sequence: MTTVYTLVSWLAILGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLAVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAEENSSVAAPLFKLCERRQGIAGVKGNQLQLMTESDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWPELMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMIMIDNYIAYTGSMNMVDPRYFKQDAGVGQWIDLMARMEGPIATAMGIIYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTAAYSAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSMLVGWASRAFFTELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLAIDDKGFGADLAAVQDDYISRSRLLDARLWLKRPLWQRVAERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACSA_DEIRA
Sequence: MTHPNDHIDAMLHETRVIHPSAEFQAGTRVSRAEYERRYRQSLDQPDDFWSEVAHDLHWMKDWDRVLDWQEPHAQWFVGGQTNIAYNALDRNVQRGLGDKRAIIWEGEDGEVRTYTYAELLREVCKAANALEELGVVAGDRVTLYMPLIPEAAIAMLACARIGAVHSIVFGGFSVSALADRINNAQSKLLITADAGYRRGKPVTLKINADEAAKLAPCLEHVLVVKRAGIPLEWWTEGRDLWWHDVVDRQSDQHEATALDSEHPLFILYTSGSTGAPKGVQHTTGGYMVGTYLTTQTVFDLRDDDIYWCTADIGWITGHSYSVYGPLLNGATVVMYEGAPNQPDWGRFWDIVQKHRVTILYTAPTAIRSFMQHGDEIPGRYDLASLRLLGSVGEPINPEAWMWYYRVIGGERCPVVDTWWQTETGSIMLTTLPGAFPSKPGSAGLPMFGVEPALMTRDGEEIGDDDGGLLVIKRPWPSMLRTVYGDDERYRKSYWGEIPHVYFAGDGARRDHDGYYTIVGRVDDVLNVSGHRLGTMEIESALVAHPDVSEAAVVGRPDPVKGESVVAYVLLQDGHTADPAALRAHVSSEIGALARPDAIYIADALPKTRSGKIMRRFLRQLAAGQPVQGDTSTLEDPTVLERLQASPAL
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: KDUI_SALSV
Sequence: MDVRQSIHSEHAKTLDTQALRREFLIENIFVADEYTMVYSHIDRIIVGGIMPVSHSVEIGGEVGKQLGVSRLLDRRELGVINIGGAGAIIVDGQRHDIGHRDALYIGKGAKELVFVSNEASRPAKFYYNCAPAHTAYPTKKVSPADVAPVTLGDNLTSNRRTINKYFVPDVLETCQLSMGLTELAPGNLWNTMPCHTHERRMEVYLYFNMEEDSCVFHMMGQPQETRHIVMRNEQAVISPSWSIHSGVGTKAYTFIWGMVGENQVFDDMDHVAVQDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.