PharMolix/UniProtQA huggingface dataset:
Protein: TGT_THEMA
Sequence: MEFEVKKTFGKARLGVMKLHHGAVETPVFMPVGTNASVKLLTPRDLEEAGAEIILSNTFHLMLKPGVEIIKLHRGLHNFMGWKRPILTDSGGFQVFSLPKIRIDDEGVVFRSPIDGSKVFLNPEISMEVQIALGSDICMVFDHCPVPDADYEEVKEATERTYRWALRSKKAFKTENQALFGIVQGGIYPDLRRESALQLTSIGFDGYAIGGLSIGEERSLTLEMTEVTVEFLPEDKPRYFMGGGSPELILELVDRGVDMFDSVFPTRIARHGTALTWNGKLNLKASYNKRSLEPVDERCGCYTCKNFTRSYIHHLFDRGEVLGQILLTIHNINFMISLMKEVRRSIESGTFKELKSKVVEVYSSGGVNV
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: ATG26_PHANO
Sequence: MASQDRGRDRSSRRLTKKRKDIGRDTRGLSLDIPERFKDGDDAQEDVTAPKRSDAMSMNQSIFSIIARAGGQSQVDLGTMQEVDSGDSDDDGKGKTLHDRLDGAARLSRLRTANDFRPPQEDSRAEKIGSGKHRRALSENKLLRSLPKLKISSRKDVRSDGQHTDQMSSSQFLPPRPSTETPSETHKRGDALKGKARATTGDEIHVEKQRKSERRGGQGSSVGLAQSRGPVSLATRIQQIFEFEHAEEVISEYPCWLLQSILLQGYMYITQKHICFYAYIPKKHHDVSKTGYLYKRGRSKYNRYWFILRGDVLSYYTNPAELYFPRNRINLQYAISAEVVENKKKGEYETIFTVTTDERTYQFKADSAASAKEWVKSIQKVIFRTHNEGNSVKISMPIRNVIEIEESSILDFADTVKVRVVDNGETFAIDEYFFSFFNRGQDALNVLRIMINDNEHHQVSTENQVNPTPITAPLKTSNRHSLVVSPIVPDDTPRIKENVRATLSPLPNPNVGRSSISDISARSSTDVPRKSWDVRRSMDASRALRRSSHEVRRSFSGGRSEKLTKSRAPDRSPLSPAADTESATLSLDPGTESSAAIQSMDESSASASQILNRSDVFRAPAIHSAGVSHSERPQQAARHSQDTTRSSGADQHLQLLVRPSKQTNTSLLPASTEAEEDTDPSQTLPRLSNSSSALQEIASYPLQKASGIAGFLRMRSKEMGSLLATESMGYYEKVSGMLAGGRKHYNTADGLEPHDQIHGIEDDDDAAKAADNFREHFAFPESEILQSSFFASLQRMLPNYGKIYISGRYFCFRSLMPTSKTKIILPMKDIENVNKEKGFRMGYHGLAIVIRGHEELFFEFSKAEYRDECAITVLRILENTKYIEEASSSSGVDSDDEAAKAEHDLLQQAREQSDTHEQIDVSEIARAADHDRIPLIFDDPLASFVDFKPPEPLTIVCLTIGSRGDVQPYISLCKELLKEGHKARIATHAEFEPWVRKHGIDFAPVDGDPAELMRICVEHGMFTYGFIKEANSKFRGWLDDVCSSSWRACQGADVLIESPSTMAGIHVAEALEIPYFRAFTMPWSRTRAYPHAFSVLENKMGGGYNNMTYQLFDKLFWTAISAQVNKWRRRELGLQNTSQSKMQANLRPFLYNFSPHVVPPPLDWPDWIRVTGYWFLDEGDTYQPPADLAAFITQARKDEKKLVYVGFGSIVIDDPAALTKTVVDSVLKADVRCVLSKGWSDRLATKDASKPEIPLPPEIFQIQAAPHDWLFKQMDAAVHHGGSGTTGASLRAGIPTIIKPFFGDQFFFAQRVEDMGVGIWLKKVNTSVFSRALWEATNSQRMIIKAKVLGQKIRKDNGPQVAIQTIYRELDRARTLVKKHVKQDDEQTDEFEEDWTMIEEGQDVDVSAHHFEAQSPLVGMNQDAPRTGGGSLVLGSMVMKGAQKRNSESAYRD
What is the function of this protein?
Probable sterol 3-beta-glucosyltransferase that mediates autophagic degradation of peroxisomes (pexophagy) (By similarity).  Also required for cytoplasm to vacuole transport (Cvt) and autophagic degradation of mitochondria (mitophagy) and nuclei (nucleophagy) (By similarity).
What are the official names of this protein?
Sterol 3-beta-glucosyltransferase, Autophagy-related protein 26.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: NU2M_SHEEP
Sequence: MNPIILIIILMTVMLGTIIVMISTHWLLIWIGFEMNMLAIIPIMMKKHNPRATEASTKYFLTQSTASMLLMMAIIINLMFSGQWTVMKLFNPMASMLMTMALAMKLGMAPFHFWVPEVTQGIPLSSGLILLTWQKLAPMSVLYQILPSINLDLILTLSILSITIGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLLYNPTMTLLNLIIYIIMTSTMFTLFMANSTTTTLSLSHTWNKAPIMTILVLITLLSMGGLPPLSGFMPKWMIIQEMTKNDSIILPTLMAITALLNLYFYMRLTYSTALTMFPSTNNMKMKWQFPTTKRMTLLPTMTVLSTMLLPLTPILSILE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PQQC_PSEAE
Sequence: MSRAAMDRAEFERALRDKGRYYHIHHPFHVAMYEGRASREQIQGWVANRFYYQVNIPLKDAAILANCPDREVRREWIQRILDHDGAPGEAGGIEAWLRLAEAVGLEREQVLSEERVLPGVRFAVDAYVNFARRASWQEAASSSLTELFAPQIHQSRLDSWPRHYPWIEAAGYEYFRSRLAQARRDVEHGLRITLEHYRTREAQERMLDILQFKLDVLWSMLDAMSMAYELERPPYHTVTRERVWHRGLAS
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: C71Y1_CATRO
Sequence: MDQLMNFSLTSPIFLLLSSLFLIILLNKLMRGNKIQKGKKLPPGPKKIAIIGNLPSNGRFTSLIVFLNNLAEKYGPIMHLRIGQLSAVIISSAEKAKEILNTHGVRVADRPQTTVAKIMLYNSLGVTFAPYGDYLKQLRQIYAMELLSPKTVKSFWTIMDDELSTMITSIKSEVGQPMILHDKMMTYLYAMLCRATVGSVCNGRETLIMAAKETSALSASIRIEDLFPSVKILPVISGLKSKLTNLLKELDIVLEDIISAREKKLLSQPQQPLMLDEEDMLGVLLKYKNGKGNDTKFRVTNNDIKAIVFELILAGTLSSAAIVEWCMSELMKNPELLKKAQDEVRQVLKGKKTISGSDVGKLEYVKMVVKESVRLHPPAPLLFPRECREEFEIDGMTIPKKSWVIINYWAIGRDPKIWPNADKFEPERFSNNNIDFYGSNFELIPFGAGRRVCPGILFGTTNVELLLAAFLFHFDWELPGGMKPEELDMNELFGAGCIRENPLCLIPSISTVVEGN
What is the function of this protein?
Involved in monoterpene indole alkaloids (MIAs) biosynthesis (PubMed:29942076).  Converts by aromatization the tetrahydro-beta-carboline alkaloids tetrahydroalstonine and ajmalicine to the corresponding beta-carboline alkaloids alstonine and serpentine, respectively (PubMed:29942076).
What are the official names of this protein?
Alstonine synthase, CrAS, Cytochrome P450 71AY1, CrCYP71AY1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: AQP1_RHIIR
Sequence: MLDAEQKKNYVAGAFGEFVGTAYFLFMGVGGAVNFLNNAAGSPLPGFAIPFCFGFSLFVNVFIWAPISGGVFNPSITIALMATNPKDFPWYRGILYIVSQFLGALFGSWLIDLIQPEAPNAATLLADGVSVAQGLFMEMFATSVLTMAVLILAGERYGKYLAPFGIGMSLFISALCAGPYTGASLNPARTLGPAIVANQYGRAHWIYYVGPTLGSLLAAGYWHILRILNIDVVDLKNVLNKCKKCGKEDPRISLKHCEECLKDDPKPEKYDIESQN
What is the function of this protein?
Water channel required to facilitate the transport of water across membranes (PubMed:23157494).  Stimulates plant drought tolerance by facilitating the transport of water from the arbuscular mycorrhiza fungus to host plants (PubMed:23157494).
What are the official names of this protein?
Aquaporin-1.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein: RS6_NEIGO
Sequence: MRHYEIVFIVHPDQSEQVPAMVERYKTMITEANGKIHRLEDWGRRQLAYPINKIHKAHYVLMNIETTPEVVGELETAFRFNDAVLRHLTIKTKHAVTEASPMLGGEKAKNLLVGAAEEAAAQ
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: IHFB_METCA
Sequence: MTKSELIESLAGKYPHLSPRDIEHAIKEMIGCMSEALAGGERIEIRGFGSFSLHHRPPRVGRNPKTGESVHLPSRRVPHFKPGKELRDRVNSIKD
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: MURE_LACLS
Sequence: MIKLEQVVEILKKDNNFREISSAGEYYFNWPKEVNFDQLSYDSRKSTKDTLFFAKGLNFKKEYLTDLEAAFYVSEFDYEVALPAIIVTDVKRAMALIAANFYKFPQNKLKTLALTGTKGKTTSAYFAKSILDKMNGGKTALLSTAQTTLDGQNYFKSELTTPESLDLLEMMAKALENGMTHLVMEVSSQAYKTERVYGLTFDVGVFLNISPDHIGPVEHPTLEDYFYCKRQLLKNSRYFVANAEMNHFAIIKEELNERKIPHAFYGADSENKIIESKGLHFVTDGSVSGEFDIRLLGRFNQENALATALATKALGASFENIRQGLASAIVPGRMELLTAKNGAHIYIDYAHNGLSLENLVEVVEDHHAGQLFLVLGSTGNKGESRRKDFGQVIENHPRLNVILTTDDSNRENPKTIADEIASFVSRELDFELDREFAIKKAISKTQNSDDAVIIAGKGADMFQLKDGKREPYIGDSPAAQKYL
What is the function of this protein?
Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramyl-tripeptide synthetase, UDP-MurNAc-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAIB_ECO45
Sequence: MDHLPMPKFGPLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQLSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVIAHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAALAALHKVRETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKDPYYAGCGLYKCADGYIVMELVGITQIAECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWLAAHTIAEVKERFAELNIACAKVLTVPELESNPQYVARESITQWQTMDGRTCKGPNIMPKFKNNPGQIWRGMPSHGMDTAAILKNIGYSENDIQELVSKGLAKVED
What is the function of this protein?
Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine.  Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.
What are the official names of this protein?
L-carnitine CoA-transferase, Crotonobetainyl-CoA:carnitine CoA-transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. CaiB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_STRP8
Sequence: MIDKRDDKPFKLKSKYKPSGDQPQAIESLVDNIEGGEKAQILLGATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYADSAVSLRPGQEISRDTLLNQLVDIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRICEIESLTGKTIGEVDHLVLFPATHFVTNDEHMEQSIAKIQAELAEQLQLFESEGKLLEAQRLRQRTEYDIEMLREMGYTSGVENYSRHMDGRSPGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDQARKQMLVDYGFRLPSALDNRPLRRKEFESHVHQIVYVSATPGEYEMSQTNTIIEQIIRPTGLLDPEIDVRPSMGQMDDLLGEINQRVARDERTFITTLTKKMAEDLTDYLKEMGVKVKYMHSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNVDGHVIMYADKMTDSMQRAIDETARRREIQIAYNKAHGIVPQTIKKDIRGFISISKTSHNDISKEEMDYESMSRGERKEAINALQKQMQEAAELLDFELAAQMRDLILELKLMD
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGMG_PARXL
Sequence: MTSLISVKRLNKSFPGVRALHEVQFELMAGEVHALMGENGAGKSTLMKILAGVYTRDSGEILYDGQPVEFLSPRDAQAVGVGIIHQELQLMNHLTVAQNIFIGREPRGRLGLLLDEDRLNAQAAAILARMHVSLDPRAVVGALTVARQQMVEIAKALSFDSRVLIMDEPTSALNDAEIAELFRIIRELKSRGVGIVYISHKMDELKQIADRVTVMRDGEYVATVAARDTSVEAIIGMMVGRTLTDIAPSHSVADQGEIALEVRNLNAGPLVRDVSFALRKGEILGFAGLMGAGRTEVARAVFGADPVESGEIVVNGARATIRTPSDAVAHGIGYLSEDRKRFGLATGMDVESNIVMSNLRKFLSLNFFLRRAQIRRTASHFISLLGIRTPSATQAVRLLSGGNQQKIVIAKWLERDCDVLFFDEPTRGIDVGAKNEIYKLLRSLAGEGKAVVMISSELPEILRMSDRVIVMCEGRITGELSAAEATQERIMHLATRRETLKTAA
What is the function of this protein?
Part of an ABC transporter complex involved in carbohydrate import.  Could be involved in ribose, galactose and/or methyl galactoside import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Putative ribose/galactose/methyl galactoside import ATP-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Carbohydrate importer 2 (CUT2) (TC 3.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VM2PA_ECHPL
Sequence: DCASGPCCRDCKFLKEGTICKRARGDNMDDYCNGKTCDCPRNPHKGEHDP
What is the function of this protein?
Inhibits ADP-induced human platelet aggregation.
What are the official names of this protein?
Disintegrin pyramidin-A.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AGL5_HALVD
Sequence: MHVLYIMGQDSGGLPHYTAELANSMSEYARVTVLKPNETSADEVLRDEITVINAFKPTDISMQNLFDLKLDVLDSIRGLFSFWNIKLINQIDPDIVHDPTDEFPQVNLFSWVHSVYEDRPYVVTSHETKHGGAGGVLRVVNPLLSLVPDFEKSAAIVHSADQRELLLNNHKAVDEVHVIPHGVYSFFRELDYDEQKEEDKHALFFGSLIPPKGIEYLIDAVPKVSEEVPGFSLTIAGSGSIPDECADVVEQYSDVINIRNEFIPNEEVGTLFSRAQVVVLPYRRGWQTGHSGTLSIAFAFGKPIITSEVGDFPELVGESGAGIVVEPESPEAIADGLIEVFSSDSALDQMSNASSRVADRLSWEKIAEQHFEVYQNLL
What is the function of this protein?
Hexosyltransferase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1. 75 M instead of 3. 4 M).  Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose.  Together with Agl6, mediates the addition of sugars 1 and 2 to dolichol phosphate in the tetrasaccharide.
What are the official names of this protein?
Low-salt glycan biosynthesis hexosyltransferase Agl5, Archaeal glycosylation protein 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family.
Protein: GPDA_SALG2
Sequence: MNQSNASMTVIGAGSYGTALAITLARNGHQVVLWGHDPKHIATLEHDRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFSDVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDETFADDLQQLLHCGKSFRVYINADFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLTEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVKGAQDKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKEELSRH
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_CERSK
Sequence: MNIHEYQAKALLRSYGAPVSDGRVVLKADEAKSAAGELGGPLWVVKAQIHAGGRGKGKFKEPEAGEKGGVRLAKSVGEAAELAKQMLGRTLVTHQTGPAGKQVNRIYIEEGSDIARELYLALLVDRGTSRISFVVSTEGGMDIEEVAASTPEKIVSFSVDPASGLSDFHGRRVAFALGLEGAQVKQCVQLVKNLYRAFVEKDMEMLEINPLIVMTDGNLKVLDAKVGFDNNALYRQSDVMALRDETEEDPKELAASKFDLNYIALDGEIGCMVNGAGLAMATMDIIKLYGAEPANFLDVGGGATKEKVTEAFKIITSDPNVKGILVNIFGGIMRCDIIAEGIIAAVKEVGLQVPLVVRLEGTNVEKGKEIIANSGLNVIAGDNLSDAAQKIVKAVKG
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: LIAS1_DROYA
Sequence: MFGMLRALKTHVEAPIVVATRAASTNAEKLEEIRERLAKGPNFQDFVQNPDNSRSEWENYEGKLRREKGEEQRLRLPPWLKTTIPVGKNYAKIKAQMRELKLSTVCEEARCPNIGECWGGGEHGTQTATIMLMGDTCTRGCRFCSVKTARKPPPLDVNEPVNTATAIASWGLDYIVLTSVDRDDLPDGGSKHIAETVREIKARNSNIFVECLVPDFRGNLECVETIANSGLDVYAHNIETVEKLTPYVRDRRAHYRQTLQVLTEAKRFNPNLITKSSIMLGLGETDEEIESTLKDLRTAGVDCVTLGQYMQPTNKHLKVIEYVTPEKFKHWEERGNELGFLYTASGPLVRSSYKAGEFFITSILENRKKRQNATELSKE
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase 1, mitochondrial, Lipoate synthase 1, LS 1, Lip-syn 1, Lipoic acid synthase 1.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: IBB_PHAAT
Sequence: SGHHHHDSSDEPSESSKACCDHCACTKSIPPQCRCALRLNCNHCRSCICTFSIPAQCVCTDTNDFCYEPCKSGHDDDDSG
What is the function of this protein?
Protease inhibitor with activity against cysteine, aspartic and serine proteases.  Highest activity against serine proteases, in particular trypsin and trypsin-like proteases.
What are the official names of this protein?
Bowman-Birk type proteinase inhibitor, TBPI-B.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.
Protein: FPG_ECO55
Sequence: MPELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSEEIYRLSDQPVLSVQRRAKYLLLELPEGWIIIHLGMSGSLRILPEELPPEKHDHVELVMSNGKVLRYTDPRRFGAWLWTKELEGHNVLTHLGPEPLSDDFNGEYLHQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSLAECELLARVIKAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATFYCRQCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: ERG6_YARLI
Sequence: MSSNIKLAQKDYKGDKEFAAALHGKEGHKKHGLGAVMSKNKDAQAAAVEGFFRNWGDKDRSKIEDADEQGRIEDYAGLTKHYYNLVTDFYEYGWGSSFHFSRYYKGEAFRQATARHEHYLAYKMGIQPGMKVLDVGCGVGGPAREIARFTGANIVGLNNNDYQVERGTHYSEVQGFGDQVTYVKGDFMQMDFPDNSFDAVYAIEATVHAPVLEGVYSEIFRVLKPGGVFGVYEWVMTDEYDESNPEHRDICYGIEKGDGIPKMYKREVAVKALENVGFDIEYQEDLAADDAEVPWYYPLAGEWKYVQSLNDIVTIGRTSRLGRMVTMNVIGALEKIGLAPQGSRQVTEALEDAAVNLVAGGKKKLFTPMMLFVSRKPEDKN
What is the function of this protein?
Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.
What are the official names of this protein?
Sterol 24-C-methyltransferase, Delta(24)-sterol C-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
Protein: IORA_METTM
Sequence: MELDDILDAGRGDRLFLLGNEAAVRAAIESGVGVASTYPGTPSSEIGNVLSKIAKRAGIYFEFSINEKVALEVAAAAAASGVRSFTFMKHVGLNVASDSFMSVAYTGVRAGMVVLSADDPSMFSSQNEQDNRHYARLAWVPLLEPSNPQEILEYMNHAFELSEEYRIPVLLRTTTRVSHMRGVVEAGERRAEPVKGFFRKNPEQFVPVPATARVMRRELVEKMKKLKRVADTSELNRVLNEDSESDLGIIASGGAFNYVYDALQTLGLDVPVLKLGFTYPFPAGLVAEFLSGLEGVLVVEEVDSVMEKEVLAVATSEGLDVGVHGKLDGTLPEIYEYSEDIVRRAISGLTGIKSHEKGIEAPELPERPPALCPGCPHRAMYYSVRRAASELGIEGEDLIFPTDIGCYTLGIEPPYSAADYLLSMGSSVGTACGFSAATSQRIVSFIGDSTFFHAGIPPLINAVHNRQRFVLVILDNRTTAMTGGQPHPGLPVDGMGEEAPAISIEDITRACGVEFVETVNPMNIRRSSETIRRALQHESVAVVISRYPCMLSEGAVRGRPVRVDEEKCDLCLECLNELACPAIVEEDGRVFIDPLYCRGCTICLQICPAGAIKPEGKR
What is the function of this protein?
Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
What are the official names of this protein?
Indolepyruvate oxidoreductase subunit IorA, IOR, Indolepyruvate ferredoxin oxidoreductase subunit alpha.
Protein: MNME_BDEBA
Sequence: MGPMIRGDRDKDTICAISTPHGVGGISVIRVSGPQTLNIVSKICQFLPAHPESHKVYFGNLKNSQTGDEIDEVLATYFKEGRSFTGEEVIEISCHGSPLICQTILNQLVNLGARPADRGEFTFRAFMNGKLDLVQAESVLSLIESQSQQAAKLALRQLKGTLSHKLEEIEDDMTWILAHAEASIDFSTEGIEVIEENVIQVRLKKIEAGLKELVATFKVGRLLKDGFRIVLTGLPNVGKSSLLNLFLEDERAIVTDIPGTTRDVIHGDTTFEGVKFTFVDTAGLRDEATDLVERIGIQKSYEAQNESDVVFFVYDIEKGLGAEELQILESLDPAKTYILANKTDKIGGSKPLETVEKTLKNSKFFQKLADPAAFFTRRVFFVSALDKKVRSEVLKDLVKEFADLQVENTVLISNARHFENLTRALENTQRSQSVVAQGLGAEFLALEFKEALIAIHETLGKRFDDQIMDRVFKEFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_CALS4
Sequence: MAAIKYQVIKKDARTKARLGILETPHGVIETPVFMPVGTQATVKAMTPDELKEMGATIILGNTYHLYLRPGHKIIEKAGGLHKFMNWDRAILTDSGGFQVFSLSSLRKITEDGVEFRSHIDGSKHFFTPEKVIEIQNSLGSDIIMSFDECAPYPADYDYVKRSMELTIKWAKRGKKAHKNTDRQALFGIVQGGTYKDLRRECAERLVDMDFPGYAIGGLSVGEPKDLMYEIIDFTTDYLPHDKPRYLMGVGTPEDLIEGVIRGVDMFDCVLPTRIARNGTVFTSRGKLIVRDAPYAEDFSPLDEECDCYTCKNYSRAYLRHLFKAKEILAARLATYHNLYFLIKLMEKIREAIRQDRLLEFKEEFLKKYYGNREE
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: LFTR_NEIMF
Sequence: MRIPLLAPDNYAFPDPAYALARCDGLVGVSRDLDAGRLLEAYRNGVFPWFLRDGWFFWYAVGPRAVIVPERLHVPRSLEKTLRNCSYRVTVNGCFAEVVAHCAAAVRPNQDGTWIAPEFQTAYLKLHEMGYAHSFECHYPDENGKTRLAGGFYGVQIGRVFYGESMFALQPDASKIAFACAVPFLASLGVELIDCQQDTGHMRRFGSELLPFADFAERLRMLNAVPLKEEIGRREVACKGL
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.