PharMolix/UniProtQA huggingface dataset:
Protein: HTRA1_BOVIN
Sequence: MQPPRAPFLPPPTPPLLLLLLLLAAPASAQPARAGRSAPGAAGCPERCDPARCAPPPGSCEGGRVRDACGCCEVCGAPEGAECGLQEGPCGEGLQCVVPFGVPASATVRRRAQSGLCVCASNEPVCGSDAKTYTNLCQLRAASRRSERLHQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIPEEIDP
What is the function of this protein?
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin.  HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production.  May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin.  Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space.  Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins.  Inhibits signaling mediated by TGF-beta family members.  This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded.  By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development.  Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity).
What are the official names of this protein?
Serine protease HTRA1, High-temperature requirement A serine peptidase 1, Serine protease 11.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell membrane. Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane.
Protein: RS19_THEMA
Sequence: MGRSRKKGPYVDRKLLEKIRKLNETGEKKVIKTWSRASMIIPEMVGHTIAVYNGMKHIPVYITENMIGHRLGEFAPTRRFGGHADKKAKKGELKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: PURT_IGNH4
Sequence: MREVLGTALTSSSQKALLLGSGELGKEVVIELQRLGVEVVAVDRYDRAPAMHVAHRRYVIDMLDYDQVVDVVRRERPDVIIPEVEAINTDALVDLEKEGYFVVPNARAVKITMNRIELRRLAAEKVGVPTTRYAFAHNEDEAAEACEKVGYPCLIKPEMSSSGHGHTLASSPEEAREGFKRALKEARGKSERAIVEEFVEIDRELTALTYRHDTGNGIETVPLPPVEHKRPKGIYYYYESWHPATVNDEVVKKAKDIAVKVVNELGGLGIFGVEILVTKDGRVLFSEVSPRPHDTGLVTLASMELSEFAIHARAVLGLPVPEPKLLTPAASRVVLAEEALEPPCLKGVGEALKVKGVQLRWFAKPRSYKERRMGVLLATGSTVEEALERVRRAAGFLKVVKC
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: COTSA_BACSU
Sequence: MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIKDPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDAVFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYSGVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIEEHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDVFVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAERINDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR
What are the official names of this protein?
Spore coat protein SA.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: TRMB_ECOL6
Sequence: MKNDVISPEFDENGRPLRRIRSFVRRQGRLTKGQEHALENYWPVMGVEFSEDMLDFPALFGREAPVTLEIGFGMGASLVAMAKDRPEQDFLGIEVHSPGVGACLSSAHEEGLSNLRVMCHDAVEVLHKMIPDNSLRMVQLFFPDPWHKARHNKRRIVQVPFAELVKSKLQLGGIFHMATDWEPYAEHMLEVMSSIDGYKNLSESNDYVPRPASRPVTKFEQRGHRLGHGVWDLMFERVK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RLMD_VIBVU
Sequence: MARFFQPKKKLQPESKHQQVLVEKLDHQGAGIAYLNKKPLFIDGTLPGEEVVTQLTESKSKFARGKLIKLLKPAAERVEPFCSHFNQCGGCDMQHMDYQAQLAYKQRTLLQLMKKFSGSEILLSPPVTGLEKAYRRRARVSLMWDKKSRQLQFGFRRKQSKQIENVTQCPVLVAELECLLPELKAILSHFQHPEHLGHVELVAADNGAVITLRHTGPLLDEDVAKLRQCAEQHQATLYLMPASDQLERISGEAPYYQEIGFKVPFEPNNFIQVNQKVNQQMVVQALEWLDPQSSDRVLDLFCGLGNFSLPIASKAKSVTGVEGVDEMVQKAAINASLNQINNAQFFHANLEQDFVGQPWASEKFDKILLDPARAGASGIIEQVSALGAKRVVYVSCNPATLARDSQSLLEQGYRLTKLGMLDMFPYTSHLESMALFEK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: GUAA_SYNP6
Sequence: MTLQTEMEAALEVAALNREMLIILDFGSQYSELIARRIRETQVYSEVLSYRTTADQIRQLSPKGIILSGGPNSVYDDYAPVCDPEIWNLGIPVLGVCYGMQLMVQQLGGQVDRAERGEYGKAALVIDDPTDLLTNVEPGSTMWMSHGDSVKTMPEGFELLAHTDNTPCAAIADHQRKFYGVQFHPEVVHSVHGMALIRNFVYHICDCEPTWTTETFVEEAIREIRARVGDKRVLLALSGGVDSSTLAFLLHRAIGDQLTCMFIDQGFMRKGEPERLMEVFNEKFKIHVEYIQARDRFLQRLEGITDPEEKRKRIGHEFIRVFEEESRRLGPFDYLAQGTLYPDVIESADTNVDPKTGERVAVKIKSHHNVGGLPKDLQFKLVEPLRRLFKDEVRQVGRSLGLPEEIVKRHPFPGPGLAIRILGEVTAEKLNILRDADLIVRQEVNRQGYYDEFWQAFAVLLPVKSVGVMGDKRTYAYPVVLRFVSSEDGMTADWSRAPYDLLETISNRIVNEVKGVNRVVYDITSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: NUOA_SALPK
Sequence: MSMSTSTEVIAHHWAFAIFLIVAIGLCCLMLVGGWFLGGRARARHKNVPFESGIDSVGTARLRLSAKFYLVAMFFVIFDVEALYLFAWSTSIRESGWVGFVEAAIFIFVLLAGLVYLARIGALDWTPARSRRERMNPETNSIANRQR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLSA_VIBPA
Sequence: MKPTAEILTDILAEVRPLIGQGKVADYIPALAKVPNNKLAIAVYTNEGEVIKAGDADESFSIQSISKALSLTLAMCLYKQEEIWARVGKEPSGQAFNSLIQLEMEQGIPRNPFINAGAIVVADLLQSRLSAPRQRLLEFVRQLSGDTHIVYDKVVAASEMMHGDRNAAIAYLMRSFGNFENEVIPVLQNYFHACALKMSCVDLAKTFSYLANKGTSVQTGKPVVSPTQTKQLNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVPGEMTIAVWSPELDASGNSLAGTKALELLSERIGRSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: MRAY_STRU0
Sequence: MFLTLIAGLISLLLTALIMPHFIKFYQMKKIGGQQMHEDVKQHLAKAGTPTMGGTVFLLVASFVSFLFAILFFSHGKSMGLITGILAIVLIYGFIGFLDDFLKIFKQINEGLTPIQKLSLQIVGGLIFYFLHVVPSGIDAINVFGFPVHLGLLYIFFVLFWVVGFSNAVNLTDGIDGLASISVVISLLTYSVIAIHQNQYDVLLLCGIMIGALLGFFIFNHKPAKVFMGDVGSLALGAMLAAISIALRQEWTLLVIGLVYVFETSSVMLQVSYFKYTKKKFGEGRRIFRMTPFHHHLELGGLSGKAERWSEWKVDAFLWSVGAVSSLIVLAILYL
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACKR1_SAGIM
Sequence: MGNCLHQAELSPSTENSSQLNLEDLWNFSYDGNDSFPEIDYDASLEAAAPCHSCNLLDDSSLPFFILASVLGILASSTVLFLLFRPLFRWQLCPGWPVLAQLAVGSTLFSIVVPILAPGLGNTRSSAPCSLGYCVWYGSAFAQALLLGCHASLGPKLGAGQVPGLTLGLSVGLWGAAALLTLPITLASDASDGLCTPIYSTELKALQATHTVACFAIFVLLPLGLFGAKGLKKVLGMGPGPWMNILWVWFIFWWPHGVVLGLDFLVRSKLLLLPTCLAQQVLDLLLNLAEALAIVHCVATPLLLALFCHQATRTLVPSLPLPERWSSPVDTLGSKS
What is the function of this protein?
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor.  Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines.  Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC.  May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).
What are the official names of this protein?
Atypical chemokine receptor 1, Duffy antigen/chemokine receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).
Protein: PROA_BACFN
Sequence: MNLNDTFAAVQAAGRHLALLPDDRINQILNAVAEAALEQTSYILSENRKDLERMSPDNPKYDRLRLTEERLRGIASDIRNVATLPSPLGRILKESIRPNGMRLTKISVPFGVIGIIYEARPNVSFDVFSLCLKSGNACILKGGSDADYSNRAIVEVIHQVLRQFNIDTHMVELLPADREATRELLHATGYVDLIIPRGSSALINFVRQNATIPVIETGAGICHTYFDEYGDTAKGAAIIHNAKTRRVSVCNALDCVIVHESRLSDLPLLCEKLKADKVIIYADPSAYQALEGHYPAGLLKPATPESFGTEFLDYKMAIKTVNSFENALGHIQEYSSRHSESIVTENPERAALFTRMVDAACVYTNVSTAFTDGAQFGLGAEIGISTQKLHARGPMGLEEITSYKWIIEGDGQTRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPDE_PSEAE
Sequence: MTTRALDTANENPEQSGSWSGVLAIAVCAFALVASEFLPVSLLTPIANDLGTTEGMAGQGIAISGAFAVLTSLFISSVAGSLNRKTLLLGLTAAMGMSGAIVALAPNYFVYMLGRALIGIVIGGFWSMSAATAMRLVPANDVPRALALVNGGNALATVVAAPLGAWLGTLIGWRGAFLCLVPVALVALAWQWTTLPSMRAGARAPGPGNVFTVFALLKRPGVMLGMLASSLFFMGQFSLFTYVRPFLETVTGVHGAHVSLVLLVIGAAGFIGTLLIDRVLQRRFFQTLVAIPLLMALIALVLTVLGGWPAIVVVLLGLWGLTGTSAPVGWWAWIARVFPEDAEAGGGLFVAVVQLSIALGSTLGGLLFDRTGYQATFFASAAMLLIAAFLTILTARSKAPAG
What is the function of this protein?
Regulates the expression of oprD which encodes the imipenem-specific porin.
What are the official names of this protein?
Transcription regulatory protein OpdE.
What is the protein family that this protein belongs to?
To B.subtilis YwfA.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TTF1_MOUSE
Sequence: MKGGTSKFKTHTETLYKKKKWSSVSEKRPQKCPSQCLESKQPQVSVLGKRRRASQTPAQETLESEWPQKAKRKKRRREPQTPAQETLESEWPQKAKKKKRRGEPQTPTQESLESEQPPVSLLGKRRRESQTPAQENSESEQPRKAKRRRKKRKGSQQPTSSLLKTPETFLKAKKTTSAHKKKKNSVLEVDMETGIILVDKENMENLLETSRKDVDIVYVDMSKGQRSAKVRETGELPAAKPQEHGCRELLGDVRSRKKQKHLQKVAPWDVVQGSQPESISLPPSEPLSSEDLEGKSTEAAVFCKKKSKKNVFRSQELEPIPDSLDDSETISERLDSTHHGGAVGAGEECESTKESHSIKKKSKKKKHKSVALATSSDSASVTDSKAKNALVDSSEGSGAVREEDVDHRPAEAEAQACSTEKHREAMQRLEPTHEEESNSESASNSAARHISEDRRESDDSDVDLGSAVRQLREFIPDIQERAATTIRRMYRDDLGRFKEFKAQGVAIRFGKFSAKENKQIEKNVQDFLSLTGIESADKLLYTDRYPEEKTLITNLKRKHAFRLHIGKGIARPWKLVYYRAKKIFDVNNYKGRYNEEDTKKLKAYHSLHGNDWKKIGAMVARSSLSVALKFSQIGGTRNQGAWSKAETQRLIKAVEDVILKKMSPQELRELDSKLQEDPEGRLSIVREKLYKGISWVEVEARVETRNWMQCKSKWTEILTKRMTHGGFVYRGVNALQAKITLIERLYELNVNDANEIDWEDLASAIGDVPPPFVQAKFYKLKAACVPFWQKKTFPEIIDYLYKNSLPLLKEKLDKKMKKKDGQIQTPAAPKQDFLFKDIFHCDDDSDEGSPEEPSASDVQ
What is the function of this protein?
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin (PubMed:7720715, PubMed:9267035, PubMed:15292447, PubMed:9049305).  Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription (PubMed:15292447, PubMed:20513429).  Interaction with BAZ2A/TIP5 recovers DNA-binding activity (PubMed:15292447).
What are the official names of this protein?
Transcription termination factor 1, TTF-1, RNA polymerase I termination factor, Transcription termination factor I, TTF-I, mTFF-I.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=May be localized to the nucleolus in an NPM1/B23-dependent manner (PubMed:20513429). May be displaced from the nucleolus into the nucleoplasm in an CDKN2A/ARF-dependent manner (PubMed:20513429). May shuttle back and forth from nucleoplasm to nucleolus (PubMed:20513429).
Protein: RL333_STAAS
Sequence: MRKIPLNCEACGNRNYNVPKQEGSATRLTLKKYCPKCNAHTIHKESK
What are the official names of this protein?
50S ribosomal protein L33 3.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PACA_URAJA
Sequence: HSDGIFTDSYSRYRKQMAVQKYLAAVLGRRYRQRVRNK
What is the function of this protein?
Stimulates adenylate cyclase in pituitary cells.
What are the official names of this protein?
Pituitary adenylate cyclase-activating polypeptide, PACAP.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: AAMA2_AMAEX
Sequence: MSDINATRLPIWGIGCNPCVGDDVTSVLTRGEA
What is the function of this protein?
Major toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters (PubMed:24050899, PubMed:24613547).
What are the official names of this protein?
Alpha-amanitin proprotein 2.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: OSTB_SCHPO
Sequence: MKSALCIALALTWSLLVQAARQTVLAVADHDIGGYSTFLQSLTDRDFDVKTSYIKDESAKLFEYGERLYDNLILLSSQSKSLGPVFSPKSLLEFVQSGGNLFVVAGSQLPEGIRELGRQLDMFLAERQSVVVDHFNHAEGSDDIILLDGISENPYIISDETRAAGPILYKGIGHYLGPNPQTQPILRGNPTSYIYNTKTEAEVSKNPWAAGTQLFLVSVLQSSTGERVGLSGSIDMLKDEYLSPQSPSFSKSNFLFARDLTNWVFQRKGVLQATNMTYGKVAEPLESRNASCYRIKDEMIFSIDISLLEDGQQTPYVADDVQLELIMLDPYYRVNLVPVPSDSQTSQHYEAVLVAPDHYGDFTFKIEYKRPGLTPIEEKSTFTLRQFFHNEFPRFLPHAYPYYASCFSVLGAFLLFCGIWLLQKPAKPVVPSAKKQN
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1, Oligosaccharyl transferase 48 kDa subunit, Oligosaccharyl transferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the DDOST 48 kDa subunit family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Membrane; Single-pass type I membrane protein.
Protein: HIS1_WOLSU
Sequence: MITVALPKGRIAEETLDRFEKIFGERFVFEDRKLILERGEFKFLLVRNQDVPTYVLHQAADIGIVGLDVLEEQESDLIRLLDLGIGRCKVVIGSPMGSEIDYSKPQIKIATKMTNIAKKHFAKQALAVDLIKLYGSIELAPLVGLADAIVDIVETGTTMKQNHLKIDEVIMESSAYMVANRNSFYEKKDKILELQRQFSKLKEVRE
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODO1_STAAU
Sequence: MTNERKEVSEAPVNFGANLGLMLDLYDDFLQDPSSVPEDLQVLFSIIKNDDSIVPALKSTSSQNSDGTIKRVMRLIDNIRQYGHLKADIYPVNPPKRKHVPKLEIEDFDLDQQTLEGISAGIVSDHFADIYDNAYEAILRMEKRYKGPIAFEYTHINNNTERGWLKRRIETPYKVTLNNNEKRALFKQLAYVEGFEKYLHKNFVGAKRFSIEGVDALVPMLQRTITIAAKEGIKNIQIGMAHRGRLNVLTHVLEKPYEMMISEFMHTDPMKFLPEDGSLQLTAGWTGDVKYHLGGIKTTDSYGTMQRIALANNPSHLEIVAPVVEGRTRAAQDDTQRAGAPTTDHHKAMPIIIHGDAAYPGQGINFETMNLGNLKGYSTGGSLHIITNNRIGFTTEPIDARSTTYSTDVAKGYDVPIFHVNADDVEATIEAIDIAMEFRKEFHKDVVIDLVGYRRFGHNEMDEPSITNPVPYQNIRKHDSVEYVFGKKLVNEGVISEDEMHSFIEQVQKELRQAHDKINKADKMDNPDMEKPAELALPLQADEQSFTFDHLKEINDALLTYPDGFNILKKLNKVLEKRHEPFNKEDGLVDWAQAEQLAFATILQDGTPIRLTGQDSERGTFSHRHAVLHDEQTGETYTPLHHVPDQKATFDIHNSPLSEAAVVGFEYGYNVENKKSFNIWEAQYGDFANMSQMIFDNFLFSSRSKWGERSGLTLFLPHAYEGQGPEHSSARLERFLQLAAENNCTVVNLSSSSNYFHLLRAQAASLDSEQMRPLVVMSPKSLLRNKTVAKPIDEFTSGGFEPILTESYQADKVTKVILATGKMFIDLKEALAKNPDESVLLVAIERLYPFPEEEIEALLAQLPKLEEVSWVQEEPKNQGAWLYVYPYVKVLVADKYDLSYHGRIQRAAPAEGDGEIHKLVQNKIIENALKNN
What is the function of this protein?
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
2-oxoglutarate dehydrogenase E1 component, Alpha-ketoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
Protein: FHUA_ECOLI
Sequence: MARSKTAQPKHSLRKIAVVVATAVSGMSVYAQAAVEPKEDTITVTAAPAPQESAWGPAATIAARQSATGTKTDTPIQKVPQSISVVTAEEMALHQPKSVKEALSYTPGVSVGTRGASNTYDHLIIRGFAAEGQSQNNYLNGLKLQGNFYNDAVIDPYMLERAEIMRGPVSVLYGKSSPGGLLNMVSKRPTTEPLKEVQFKAGTDSLFQTGFDFSDSLDDDGVYSYRLTGLARSANAQQKGSEEQRYAIAPAFTWRPDDKTNFTFLSYFQNEPETGYYGWLPKEGTVEPLPNGKRLPTDFNEGAKNNTYSRNEKMVGYSFDHEFNDTFTVRQNLRFAENKTSQNSVYGYGVCSDPANAYSKQCAALAPADKGHYLARKYVVDDEKLQNFSVDTQLQSKFATGDIDHTLLTGVDFMRMRNDINAWFGYDDSVPLLNLYNPVNTDFDFNAKDPANSGPYRILNKQKQTGVYVQDQAQWDKVLVTLGGRYDWADQESLNRVAGTTDKRDDKQFTWRGGVNYLFDNGVTPYFSYSESFEPSSQVGKDGNIFAPSKGKQYEVGVKYVPEDRPIVVTGAVYNLTKTNNLMADPEGSFFSVEGGEIRARGVEIEAKAALSASVNVVGSYTYTDAEYTTDTTYKGNTPAQVPKHMASLWADYTFFDGPLSGLTLGTGGRYTGSSYGDPANSFKVGSYTVVDALVRYDLARVGMAGSNVALHVNNLFDREYVASCFNTYGCFWGAERQVVATATFRF
What is the function of this protein?
Involved in the uptake of iron in complex with ferrichrome, a hydroxamate-type siderophore.  Binds and transports ferrichrome-iron across the outer membrane (PubMed:1089064, PubMed:2066336).  In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages T1, T5, phi80 and UC-1 (PubMed:1089064, PubMed:353030, PubMed:2066336, PubMed:8617231).  The energy source, which is required for all FhuA functions except infection by phage T5, is provided by the inner membrane TonB system (PubMed:353030, PubMed:9353297, PubMed:12427941).
What are the official names of this protein?
Ferrichrome outer membrane transporter/phage receptor, Ferric hydroxamate receptor, Ferric hydroxamate uptake, Ferrichrome-iron receptor.
What is the protein family that this protein belongs to?
Belongs to the TonB-dependent receptor family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: GBGT1_MOUSE
Sequence: MTRPRLAQGLAFFLLGGTGLWVLWKFIKDWLLVSYIPYYLPCPEFFNMKLPFRKEKPLQPVTQLQYPQPKLLEHGPTELLTLTPWLAPIVSEGTFDPELLKSMYQPLNLTIGVTVFAVGKYTCFIQRFLESAEEFFMRGYQVHYYLFTHDPTAVPRVPLGPGRLLSIIPIQGYSRWEEISMRRMETINKHIAKRAHKEVDYLFCVDVDMVFRNPWGPETLGDLVAAIHPGYFAVPRRKFPYERRQVSSAFVADNEGDFYYGGALFGGRVARVYEFTRACHMAILADKANSIMAAWQEESHLNRHFIWHKPSKVLSPEYLWDERKPRPRSLKMIRFSSVKKNANWLRT
What is the function of this protein?
Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer) (PubMed:14573676).  Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens (PubMed:14573676).  Conversely, it diminishes Shiga toxins susceptibility (PubMed:14573676).
What are the official names of this protein?
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, Forssman glycolipid synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 6 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.