PharMolix/UniProtQA huggingface dataset:
Protein: PSAB_EUGGR
Sequence: MATKFPKFSQGLAQDPTTRRIWFGIATSHDFESHDGMTENNLYQKIFASHFGQLAIIFLWTSGNLFHVAWQGNFEQWIKDPLHIRPIAHAISDPHFGQPAIEAFTRSQFPGPVNIAYSGVYQWWYTIGLRTNVDLYNGSMFLLFIATLALFAGWLHLEPKYSPKVSWFKDAESRLNHHLSALFGLSSLAWSGHLIHVAIPESRGIHVRWDNFLSQLPHPSGLEPFFKGNWSLYSENPDSLTHVFGTASGAGTAVLTFLGGFHPETKSLWLTDIAHHHLAIAVLFIVAGHMYRTNFAIGHRIDDILNAHKAPSGKLGLGHFGLYETINNSLHFQLGLALASLGVITSLVAQHMYSLSPYAFLIQDRTTMAALYTHHQYIAGFIMTGAFAHGAIFFIRDFDEEKNKGNVLSRILDHKEAIISHLSWVTLFLGFHTLGLYVHNDVMQAFGTPEKQILIEPVFAQWIQSAHGKNIYELNILLSSDSSNAFSASQAIWLPGWLNGINDKSTSLFLQIGPGDFLVHHAIALGLHTTTLILVKGALDARGSRLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWTTFYWHWKHITLWQGNVGQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLAVWGWMFLFGHLVWATGFMFLISWRGYWQELIETLVWAHERTPITNVFKWTDKPVALSIVQARLVGLAHFSVGYVFTYAAFLIASTSAKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y4078_MYCPA
Sequence: MPRTDDDSWEITESVGATALGVAAARAAETESENPLISDPFARVFLDAAGDGMWNWFAAPNLPAQIAEAEPDLKPRMQGMVDYMAARTAFFDNFFLAATHAGVRQVVILAAGLDSRAWRLPFEDGTTVYELDQPRVLEFKATTLAEHGARPTCHLVSVPVDLRHDWPAALRQAGFDAHAPSAWSAEGLLPFLPAAAQQLLFERVQTLAAPGSRIAVEAPGPDFIDEAARERQRQTMQRVRDLMADLEPDRDIPDVQDLWYFEEREDVGDWLGRHGWDVTVTPAPELMARYDRRPPHDIEDAIPQTRFVAAQRTERTRPDR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_4078.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: HXA2_NOTVI
Sequence: GSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNGEGKGKGLEEGDRSEDEEEKAL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A2, Homeobox protein Hbox-2.8, NvHbox-2.8.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPP_STRPC
Sequence: MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGKTIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_SERMA
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQSIITEGLKAVAAGMNPMDLKRGIDKAVVAAVEELKKLSVPCSDSKAIAQVGTISANSDETVGKLIAEAMEKVGKEGVITVEEGTGLQDELDVVEGMQFDRGYLSPYFINKPETGSVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKDMLQDIATLTAGTVISEEIGLELEKATLEDLGQAKRVVINKDTTIIIDGVGDEATIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRVAGKIAALKGDNEDQNVGIKVALRAMEAPLRQIVVNAGEEASVIANQVKAGEGSYGYNAYSEEYGDMIAMGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKADAPDLGAXGGMGG
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_TERTT
Sequence: MINDIKKDAEARMKKTVEALGINFNKIRTGRAHPSILDGVSVSYYGSDTPLSQVANISVLDARTLSLSPWEKSMVPEIEKAIMKSDLGLNPVTTGELIRVPMPALTEESRKGYIKQAKTEAEQARVSIRNVRRDVLADVKELLKEKEISEDDDRRAQDDIQKITDKYVAEVDAALAVKEKDLMEI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GEP3_ZYGRC
Sequence: MLKEQFLNAFDHPSRCLFMTLRFRRWFSTTLARLINCNSCGIKLQNENPKTIGYYIKPKKPTVNKLQSLEDVKYLLFSQDLQHVKEQQDVGSLEELNETMESPLICKRCNDALHRNQYDLKEFGRYTITDVLEKIPRGSNILHVVPLPEFPFHFEKSLLEVPHFNTSLLLTKGDQLANDKNTLQRRSLVFFKDFLKYQLGIISNKTVAVSGLKNWNIQSAYAAMNANSYLVGDANVGKSTLINSVMQRYLGYKIHTDRKGQIVTNEPSVKDLKNIKHFFKNQFAGVSHIPNMTRNLQGYRVGDKFIYDLPGFTTNINGAYYEDIIQKDWLERTRKTEKFNTKKLKKQRYISVKGNEKGNCYTVGGIFFWQPPAGTVNQVVSYIPGEGREFADINRGLEVFRACQDDAHPLAKFCGVHPQICQRENYVRHVIPPFQGSIEVVLKDIGYFTIKTTGRYQFKGLHEFWVPRGIDVLVREPLESLISEGSWRHTESKGRVPACPKDRPIVSSTYIVDPEESDLLGKMKEMYLERTSNDISSRRFLYDDPLEVVSKLHEERPNLYWYYRW
What is the function of this protein?
May be involved in the mitochondrial lipid metabolism.
What are the official names of this protein?
Genetic interactor of prohibitins 3, mitochondrial, Found in mitochondrial proteome protein 38.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS19_SALG2
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPLRTWSRRSTIFPNMIGLTIAVHNGRQHVPVFVSDEMVGHKLGEFAPTRTYRGHAADKKAKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: LECG_BOTPA
Sequence: NNCPQDWLPMNGLCYKIFDELKAWKDAEMFCRKYKPGCHLASIHLYGESPEIAEYISDYHKGQSEVWIGLWDEKKDFSWEWTDRSCTDYLSWDKNQPDHYKNKEFCVELVSYTGYRLWNDQVCESKNAFLCQCKF
What is the function of this protein?
This lectin displays hemagglutinating activity on dog (128'000 HU/mg) and cat erythrocytes, that is inhibited by beta-galactosides (D-galactose, D-lactose, and N-acetyl-D-galactosamine) and EDTA.  In addition, has been shown to hemagglutinate promastigote forms of Leishmania amazonensis.  Also inhibits Gram-positive (S. aureus ATCC 25923) (MIC is 31. 25 ug/ml) but not Gram-negative (E. coli ATCC 25922) bacteria.  Is a calcium-dependent lectin.
What are the official names of this protein?
C-type lectin BpLec, BpL, CTL.
What is the protein family that this protein belongs to?
Belongs to the true venom lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROB_EXISA
Sequence: MVTIPISASTPYDVVLDNQDRWIDSVDWSRYSMLWVVTDKHVESLYGESFRSTLKLTHPHVVSSVVEAGDASKSLSQLEQLVAEGLRHGCDRETLIVAFGGGMIGDLAGFLASVYMRGVPYIQVPTTILAHDSAVGGKVAVNHPLAKNAIGSFYQPSGVYYNVTRLNTLSVQEVRSGLGELLKHAYLSRYVLESSFEDDLFLDLNENEPLDWVSWLARGIRVKQAIVETDEREQGIRAWLNFGHTFGHALESVEAYRIPHGEAVLHGMVFAFLVSGDEVRAMRLFDWMRSNDVTPIDWQPFDRYVEKMIRDKKNRHGAIRFVLLRETITVESVQLEHLQQTFEQMKGWWER
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDPK5_ORYSJ
Sequence: MGNTCGVTLRSKYFASFRGASQRHDEAGYAPVATSAAAAAAADEPAGKKAPRGSAAAADAPHAASMKRGAPAPAELTANVLGHPTPSLSEHYALGRKLGQGQFGTTYLCTDLATGVDYACKSIAKRKLITKEDVEDVRREIQIMHHLAGHRNVVAIKGAYEDPQYVHIVMELCAGGELFDRIIERGQFSERKAAELTRIIVGVIEACHSLGVIHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQVFTDVVGSPYYVAPEVLRKCYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSDPWPVISDSAKDLIRRMLNPRPKERLTAHEVLCHPWICDHGVAPDRPLDPAVLSRIKQFSAMNKLKKMALRVIAESLSEEEIAGLKEMFKAMDTDNSGAITYDELKEGMRKYGSTLKDTEIRDLMEAADVDNSGTIDYIEFIAATLHLNKLEREEHLVAAFSYFDKDGSGYITVDELQQACKEHNMPDAFLDDVIKEADQDNDGRIDYGEFVAMMTKGNMGVGRRTMRNSLNISMR
What is the function of this protein?
May play a role in signal transduction pathways that involve calcium as a second messenger.
What are the official names of this protein?
Calcium-dependent protein kinase 5, OsCDPK5, OsCPK5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor.
Protein: SCPA_LISW6
Sequence: MVEMNFKVDAFEGPLDLLLHLIGQLEVDIYDIPMAEITDQYMEFVHTMQEMELDVASEYLVMAATLLAIKSKMLLPKQELEIDYDTLEEEEDPRDALVEKLMEYKRFKEAAKELKEKEAERSFYFSKPPMDLAEYDDGTKVAELDVSLNDMLSAFNKMLRRKKLNKPLHTRITTQEISIDDRMNSVLGKLNQQKNHRLRFDELFEEQTKEQLVVTFLALLELMKRKLVEVEQSESFADLYVQGKGEELS
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: YCF2_RANMC
Sequence: MKRHPLKSWIFELREILREIKNSHYFLDSWTKFDSVGSFTHIFFHQERFMKLFDPRIWSILLSRDSQGLTSNRYFTIKGVVLLAVAVLIYRINSRNMVERKNIYLMGLLPIPMNSIGPRNDALEESFGSSNINRLIVSLLYLPKGKKISESCFMDPKESTLVLPITKKCIMPESNWGSRWRRNQIGKRRDSSCKISNETVAGIEISFKEKDLKYLESPFVSYTDDPIRKDHDWELFDRLSPRKKRNIINLNSGQLFEILVKHWICYLMSAFREKRPIEVEGFFKQQGAGSTIQSNDIERVSHLLSRNKWGISLQNCAQFHMWQFRQDLFVSWGKNPHELDFLRNVSRENWIWLDSVRLVNKDRFFSKVRNVSSNMQYDSTRSIFVQVTDSSQLKGSSDQSRDHLDSISHEDSEYHTLINQSEIQQLKERSILWDPSFFQTERTEIELDRFPKRLSGDSSMSRLFTEREKPMIIHRLPEEIEEFLGNPTRSIRSFFSDRWSELHLGSNPTEGSTRDQKLLKKQQDFSFVPSRRSENKEMVDIFRIITYLQNTVSIHPILSDPGCDMVPKDEPDMDSSNKISFLNQNSFFYLFHLFHDRNRGGYTLHHDFESEEKFQEMADLLTLSITEPDLVYHKGSAFSIDSYRLDQKKFLNEVFNSRDESKKKSLLVLPPIFYEENESFYQRIRKKWVQISCGNALEDPKQKRVVFASNNIMKAVNQYRFIQNLIQIQYSTHGYIRNVSNQFFKRSDRNFEYGIQRDQIGNDTLNHRTIMKYTINQHLSNLKKSQKKWFDPLISRTERSTNRYPDAYRYKWSKGSKNLQEHLEHFVAEQKSLFQVVFDRLRINQNSIDWSEVIDKQYFSKSLRFFLSKSLLFLSKSLPFFFVSIGNIPSHRSEIHIYELKGPNDQLCNQLLESIGVQIVHLNKWKSFLLDDHDTSQKSKFLINGGRISPFLFNKIPKWMIESFHTRNNRRKSFDNADSYFSMISHDRDNWLNPAKPFHRSSLISSFYKANRLRFLNNPHHFWFYCNKRFPFYVEKARINKYDLTYGQFLNILFIRKKIFSLCVGKGKKKHVFGERDTISPIESQVSNIFIPNDFPQSGDETYNLYKSFHFPIRPAPFVRRALYSIADISGTPLTEGQIVHFERTYCQPLSDMNPSDSEGKNLHQYFNFNSNMGLIHTPYSEKYLPSEKRKKRSLCLKKCVEKRQMYRTFQRDSTFSNLSKLNLFQTYMPWFLTSAGCKYLNLTLLDTFSDLLPILSISQKWVSIFHDIMRGSDISWPIPQKKLWAILPQWNLISEISSKCLHDLLLSEETIRRHNESPVPLIWAHLRSPNARELLYSILFFLLVAGYLVRTHLLFVSRASSELQTEFEKIKSLMIPSYMIELRKLLDGYPTSERNSFWLKNLFLVALKQFGDSLEEIRGSASGGNMLLGGGPAYGVKSIRSKKKYWNINLVDIMDLISIIPNPINRITFSRNTGHLSRTSKEIYSLIRKRKNVNGDWIDDKIESWVANSDSIDDEEREFLVQFSTLTTEKRIDQILLSLTHSDHLSKNDSGYQMIEQPGSVYLRYLVDIHKKNLMNYEFNRSCIAERRIFLAHSQTITYSQTSCGANSFHFPSPGKPFSLRLALSPSRGILVIGSIGTGRSYLVKYLATNSYVPFITVFPNKFLDDKPKGYLIDDIDIDDSDDIDDSDDIDDSDDIDDDLDTELLTMTNALTMYITPKIDRFDITLPFELAKAMSPCIIWIPNIHDLYVNESNYLSLGLLVNHLSRDCERCSTRNILVIASTHIPQKVDPALIAPNKSNTCIKIRRLLIPQQRKHFFTLSYTRGFYLEKKMFHTNGFGSITMGSNARDLVALTNEALSISITQKKSIIDTNTIRSALHKQTWDLRSQVRSVQDHGILFYQIGRAIAQNVLLSNCPIDPISIYMKKKSCKEGDSYLYKWYFELGTSMKKLTILLYLLSCSAGSVAQDLWSPPGPDEKNGITSYGFVENDSDLVHGLLEVEGVLVGSSPTEKDCSQFYKDRVTLLLRSEPRNPFDMMQNGSYSIVDQRFLYEKYELEFEEGGGEGALDPQQLEEDLFNHIVWAPRIWHPCGNLFDCIERPNELGFPYWARSFRGKRIIYHKEDELEENDSEFLQSGTMQYQTRDRSSKEQGFFRISQFIWDPADPFLFLFKDQPFVSVFSRREFFADQEMPKGLLTSQTNSPTSIYKRWFIKNTQEKHFELLIHRQRWLRTNSSLSNGSFRSNTLSESYQYLSNLFLSNGTLLDQMTKTLLRKRWLFPDEMKHLIHVTGERFPIP
What is the function of this protein?
Probable ATPase of unknown function.  Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis.
What are the official names of this protein?
Protein Ycf2.
What is the protein family that this protein belongs to?
Belongs to the Ycf2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: KLH31_HUMAN
Sequence: MAPKKKIVKKNKGDINEMTIIVEDSPLNKLNALNGLLEGGNGLSCISSELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI
What is the function of this protein?
Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions.  Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).
What are the official names of this protein?
Kelch-like protein 31, BTB and kelch domain-containing protein 6, Kelch repeat and BTB domain-containing protein 1, Kelch-like protein KLHL.
Protein: SPOP_PONAB
Sequence: MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS
What is the function of this protein?
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.  In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.  In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation.  Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation.  The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.  Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability.
What are the official names of this protein?
Speckle-type POZ protein.
What is the protein family that this protein belongs to?
Belongs to the Tdpoz family.
Protein: RL18_NEIMA
Sequence: MDKHTTRLRRARKTRARIADLKMVRLCVFRSNNHIYAQVISAEGDKVLAQASTLEAEVRGSLKSGSNVEAAAIVGKRIAEKAKAAGVEKVAFDRSGFQYHGRVKALAEAARENGLSF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: HDAC5_HUMAN
Sequence: MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C.  During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.  Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.  Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758).  In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758).
What are the official names of this protein?
Histone deacetylase 5, HD5, Antigen NY-CO-9.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Protein: PAPD1_HUMAN
Sequence: MAVPGVGLLTRLNLCARRRTRVQRPIVRLLSCPGTVAKDLRRDEQPSGSVETGFEDKIPKRRFSEMQNERREQAQRTVLIHCPEKISENKFLKYLSQFGPINNHFFYESFGLYAVVEFCQKESIGSLQNGTHTPSTAMETAIPFRSRFFNLKLKNQTSERSRVRSSNQLPRSNKQLFELLCYAESIDDQLNTLLKEFQLTEENTKLRYLTCSLIEDMAAAYFPDCIVRPFGSSVNTFGKLGCDLDMFLDLDETRNLSAHKISGNFLMEFQVKNVPSERIATQKILSVLGECLDHFGPGCVGVQKILNARCPLVRFSHQASGFQCDLTTNNRIALTSSELLYIYGALDSRVRALVFSVRCWARAHSLTSSIPGAWITNFSLTMMVIFFLQRRSPPILPTLDSLKTLADAEDKCVIEGNNCTFVRDLSRIKPSQNTETLELLLKEFFEYFGNFAFDKNSINIRQGREQNKPDSSPLYIQNPFETSLNISKNVSQSQLQKFVDLARESAWILQQEDTDRPSISSNRPWGLVSLLLPSAPNRKSFTKKKSNKFAIETVKNLLESLKGNRTENFTKTSGKRTISTQT
What is the function of this protein?
Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts.  Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro).  Plays a role in replication-dependent histone mRNA degradation.  May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated.  Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.
What are the official names of this protein?
Poly(A) RNA polymerase, mitochondrial, PAP, PAP-associated domain-containing protein 1, Polynucleotide adenylyltransferase, Terminal uridylyltransferase 1, TUTase 1, mtPAP.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
Protein: QUEC_CHESB
Sequence: MKTFVICSGGLDSVSLAHKVAVEKTLAGLISFDYGQRHKKELDFARACAQRLDVRHMIIDIRAVGEGLAGSALTDEIDVPNGHYAEDTMRITVVPNRNAIMLAIAFGVAAAQNADAVATAVHGGDHFIYPDCRPGFIEAFQAMQAQALDGYAKIALYAPYVNLSKANIVSDGVRHRTPFEATWSCYKGGKHHCGRCGTCVERREAFDLAGVTDPTTYEDAAFWREAVARKAG
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: PYRF_ECOBW
Sequence: MTLTASSSSRAVTNSPVVVALDYHNRDDALAFVDKIDPRDCRLKVGKEMFTLFGPQFVRELQQRGFDIFLDLKFHDIPNTAAHAVAAAADLGVWMVNVHASGGARMMTAAREALVPFGKDAPLLIAVTVLTSMEASDLVDLGMTLSPADYAERLAALTQKCGLDGVVCSAQEAVRFKQVFGQEFKLVTPGIRPQGSEAGDQRRIMTPEQALSAGVDYMVIGRPVTQSVDPAQTLKAINASLQRSA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: YORF_BACSU
Sequence: MTENKTVLREASNVVTIEGTLAEVRHTEWKNGNGLNIELDIEVAPNEVHTVKGFSKYKKDDGTDNAVAKGYQTIVSEYKSIAKHGRDEADKVRITQGKISLNEYYSHGIFKSYPQLMANFVNRLDANEEFNPRAEFDVEVFVKNVTEEKVKGEETGRVNLNGYIPVYNGKVIPFTFVVTKEGSQYVENNYEKGTTVNVFGKIINYKEQKVTTKVAAFGEDKKEITSITRREYLITGGNDPYDEDSKNAFNADAIKKALTEREIYLDELKKEGNKENNKKSGFGGSAPNNKPSKPVEISDDDLPF
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YorF.
Protein: Y436_STAAS
Sequence: MRGGGNMQQMMKQMQKMQKKMAQEQEKLKEERIVGTAGGGMVAVTVTGHKEVVDVEIKEEAVDPDDIEMLQDLVLAATNEAMNKADELTQERLGKHTQGLNIPGM
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein SAS0436.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: METL9_CHICK
Sequence: MRLWLCWLGCYTLLLWALRRRMWAGPARYLRSPLSRSLYANMMGSHGPPAPGAGENHQWYVCNTEQLSESLQPIFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSIFSLFMSRTSINGLLGRGSMFVFSPEQFQRLLKINPEWKSHRLLDLGAGDGEVTKVMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTVLKDTRSVLEPTRGRVILALVLPFHPYVENVGGKWEKPSEVLEIKGHTWEEQVNSLPEVFGKAGFAIEAFTRLPYLCEGDMYNDYYVLDDAVFVLKPV
What is the function of this protein?
Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (By similarity).  Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid); 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (By similarity).
What are the official names of this protein?
Protein-L-histidine N-pros-methyltransferase, Methyltransferase-like protein 9.
What is the protein family that this protein belongs to?
Belongs to the METTL9 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Mitochondrion. Note=Colocalizes with membranous compartments such as the endoplasmic reticulum and mitochondria.