PharMolix/UniProtQA huggingface dataset:
Protein: HOG1_NEUCR
Sequence: MAEFIRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSAKDQLTNQNVAIKKIMKPFSTPVLAKRTYRELKLLKHLRHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPKRERQPLKNKFKNADSSAVDLLERMLVFDPKKRITATEALSHEYLAPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVEASGQMMFQEDVPPQ
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes.  Involved in ion flux-mediated turgor regulation.
What are the official names of this protein?
Mitogen-activated protein kinase hog-1, MAP kinase hog-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: F181A_HUMAN
Sequence: MPLEERRSSGERNDAAPTNHRRPGEKRASTAKQVSSVPFLGAAGHQQSLPSSWKASCSGPLVMASDSDVKMLLNFVNLASSDIKAALDKSAPCRRSVDHRKYLQKQLKRFSQKYSRLPRGLPGRAAEPYLKRGSEDRPRRLLLDLGPDSSPGGGGGCKEKVLRNPYREECLAKEQLPQRQHPEAAQPGQVPMRKRQLPASFWEEPRPTHSYHVGLEGGLGPREGPPYEGKKNCKGLEPLGPETTLVSMSPRALAEKEPLKMPGVSLVGRVNAWSCCPFQYHGQPIYPGPLGALPQSPVPSLGLWRKSPAFPGELAHLCKDVDGLGQKVCRPVVLKPIPTKPAVPPPIFNVFGYL
What are the official names of this protein?
Protein FAM181A.
What is the protein family that this protein belongs to?
Belongs to the FAM181 family.
Protein: LCPS_SORMK
Sequence: MYDYAFVHLKFTIPLAVLLTAIAYPVLNRIHVIQTGCLIFIAFTAALPWDAYLIEQKVWSYPPEAIVGPRLLGIPFEELFFFVIQTYITALVYILFNKPVLHALHLNNQRNPPAWMRIAKVTGQLILVALSVWGWKAAQVNQKTTYLGLILVWACPFLLAIWTLAGRFILSLPWFVTVLPVVLPTFYLWAVDELALHRGTWSIGSGTKLEYCLFGKLDIEEATFFLVTNMLIVSGMAVFDQYLAVIYAFPTLFPKVNRYPTPLMLVQSRLVNTTKYDLERIEGLREAVERLRLKSRSFYLANSLFSGRLRIDLILLYSFCRLADDLVDDAKSRLEVLSWTAKLNHFLDQHYGDSDATEDPKQKAERIDAYIKEAFPPFAYQALHLLPTHILPPKPLYELIKGFEMDSQFTFHGSSDSTNLKFPIAHDKDLKTYAIRVAGTVGELCIALIIHHCLPDMSDSQKRRLESAACRMGIALQYVNIARDILVDAQIGRVYLPTSWLKEEGLTHKAVLDNPEGPEVIEKMRRRLLDNAFELYREARPEMQQIPSEARGPMIGAVENYMEIGRVLREKKVGQVFVRKEGRATVPKQRRLRTLLRALYEQ
What is the function of this protein?
Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).
What are the official names of this protein?
Bifunctional lycopene cyclase/phytoene synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the phytoene/squalene synthase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RUVA_METPB
Sequence: MIGKLKGIVDSYGEDFVILDVNGVGYVVHCSARTLQRLPKPGEATDLAIETHVREDMIRLYGFRSDAEREWFRLLQTVQGVGTRVALGVLSVLEPAQLATAIATGDKGAVARAPGVGPRLAARLVAELKDKAPAFAPVDPALVALTGAVEDRTAPQPVADAISALVNLGYPQVQASAAIAAALKGLGDGAETVEAKTLIRLGLRELAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PHL7_ARATH
Sequence: MEADNGGPNSSHASKQRLRWTHELHERFVDAVAQLGGPDRATPKGVLRVMGVQGLTIYHVKSHLQKYRLAKYLPDSSSEGKKTDKKESGDMLSGLDGSSGMQITEALKLQMEVQKRLHEQLEVQRQLQLRIEAQGKYLKKIIEEQQRLSGVLGEPSAPVTGDSDPATPAPTSESPLQDKSGKDCGPDKSLSVDESLSSYREPLTPDSGCNIGSPDESTGEERLSKKPRLVRGAAGYTPDIVVGHPILESGLNTSYHQSDHVLAFDQPSTSLLGAEEQLDKVSGDNL
What are the official names of this protein?
Myb family transcription factor PHL7, Protein PHR1-LIKE 7.
What is the protein family that this protein belongs to?
Belongs to the MYB-CC family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPO10_HALLT
Sequence: MMIPVRCFTCGNVVGEHWEEFKERAREGDEDPGKVLDELGVDRHCCRRMMVSHRDLVDVVSPYQ
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit N.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_YERPS
Sequence: MKSSIVAKLEALQERHEEVLAYLGDASVIADQDRFRALSREYAQLTDVTRCFKEWRSAQDDIEAAEMMLDDLEMREMAQEELKIAKARSEELEQQLQVLLLPKDPDDERDCFLEIRAGTGGDEAAIFAGDMFRMYSRYAETRRWKVEIMSASEGEHGGYKEVIAKISGDGVFGQLKFESGGHRVQRVPETESQGRIHTSACTVAVMPAIPEAELPEINAGDLRIDTFRSSGAGGQHVNTTDSAIRITHIPTGIVVECQDERSQHKNKAKAMSVLGARIRAAEMQKRQLAEASERRNLLGTGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIQPIVQEYQADQLSALSEQD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LARC_DESHD
Sequence: MKAAYLDCFSGISGDMLLGALVDAGLDFNLLQRDLAGLDLDEYELYEQKVLKQGIRGTQIHVHALEGHVHRHLSDIQAIIGRSALPPQVKEKSLEIFTRLGKAEAKIHGTDIEQIHFHEVGAVDAIVDIVGAVIGFWRLGIEKVFASPIHVGKGFVKAAHGLLPVPAPATLELLTGVPIYAQDVEGELATPTGAAIVTAYCREFGPFPKIRVERVGYGAGVKDLTIPNLLRLTVGELADEDKGQEGIREGEALTLEVNIDDMNPECYDYLFEKLFQAGAMDVYIQTIQMKKNRPAVLLTVQTPYHKLEEMRKILFQETTTIGLRVYPIKKYMLPYELFTVETNYGSAKVKVAFMEGRACTVSPEYEDCRRLARLTGEPLKQIYEEIKEKAKILLYSTKYPID
What is the function of this protein?
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex).  Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor.  Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
What are the official names of this protein?
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein, P2TMN nickel insertion protein, Nickel-pincer cofactor biosynthesis protein LarC.
What is the protein family that this protein belongs to?
Belongs to the LarC family.
Protein: E4PD_ECO5E
Sequence: MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_HALOH
Sequence: MAKKVIGKIKLQIPAGKANPAPPVGPALGQHGVNIMEFCKAFNAKTQDQAGMIIPVEITVYADRSFDFITKTPPASDLLKKAAGLERASGQPNINKVGTVTKEDIKEIAELKMPDLNAGSLEAAMRMIEGTARSMGIVVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SUCC_BRUMB
Sequence: MNIHEYQAKRLLHTYGAPIANGVAVYSVEQAEEWAKTLPGPLYVVKSQIHAGGRGKGKFKELPADAKGGVRLAKSVEEVVANAKEMLGNTLVTKQTGEAGKQVNRLYIEDGADIERELYLSILIDRSVGRPAFVVSTEGGMDIEAVAEETPEKIVTVAIDPAKGVTDEDANKLADALKLEGGAREDGLKLFPILYKAFTEKDMSLLEINPLIVMTNGRVRVLDAKVSFDNNALFRHPDIVELRDLTEEDPKEIEASKYDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGAEPANFLDVGGGASKEKVTAAFKIITADPAVEGILVNIFGGIMKCDVIAEGVIAAVKEVGLKVPLVVRLEGTNVELGKKIINESGLNVISADDLDDAAQKIVAAVKGN
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RIK1_SCHPO
Sequence: MALCVHSFWATAVDTATSCHFISSENCLVLLQALKINIYLCSEVHGLQFFTSIPLFSTVKHIRPYRPPGLDRDYLFVVLNDDTYFSIYWDEDYQKVIVDHPPVRYRVTFPWNRNAKSYCLVDLRMRAIFLSIDEISMICIRILSAEERLKTGRSIDSGFPFSFPVHLIYDMCILNDSSTPTLVVLHSDGLDCYVTAFLLDLSSKSLGKGIRLFERVKPSMIMPFGKRGLLVFESLFIHCMYRGNFVTINGPCTTYMHWTPLKGQKMHYIVCDTNGYLFGVYSSILGKNKWSLVMERLPIPPFDFITSLNSIHEGLLFIGSKNSESKLINLSTLKDVDSIPNLGPIHDLLVLKNDIEKSFLVCAGTPRNASLIYFQHALKLDILGQTKISGILRAMVLPSYPEHKLFLGFPSETVAFNIKEDFQLELDPSLSTKERTIALSGTNGEFVQVTSTFLCIYDSAKRSRLVYIEKITNAACYQEYSAIVINGTALAIFKKDTEVARKVFESEISCLDFSAQFQIGVGFWSKQVMILTFSDNSSISCAFQTNVPSLPRNIILEGVGVDRNLLLVSSGSGEFKSYVLFKNNLVFSETKHFGTTPVSFRRFTMNIGTYIICNNDCPHMVYGFNGALCYMPLSMPQSYDVCQFRDNSGKDFLISVSLGGLKFLQLNPLPELTPRKVLLEHVPLQAIIFQNKLLLRTLENRYEDYESYKENYHLELVDSYDDNSFRVFSFTENERCEKVLKINESSLLVGTSIIEQDKLVPVNGRLILLEFEKELQSLKVVSSMVLSAAVIDLGVYNDRYIVAFGQQVAIVKLTEERLMIDSRISLGSIVLQLIVEGNEIAIADSIGRFTIMYFDGQKFIVVARYLFGENIVKAALYEGTVYIIATNSGLLKLLRYNKDAKNFNDRFICESVYHLHDKVSKFQNFPITNTNSFLEPKMLFATEIGAIGSIVSLKDKELELEELTRKIRKLKFSYLSSMDYESIEADLISPVPFIDGDLVIDVKRWASSELFRLCRSVEHRESLNSYQKVQALLEEIQSLC
What is the function of this protein?
Component of the Clr4 methyltransferase complex (ClrC) which contributes to the establishment of heterochromatin by specifically methylating histone H3 to form H3K9me (PubMed:16024659, PubMed:8138176, PubMed:15372076).  ClrC preferentially ubiquitylates H3K14 and ClrC-mediated H3 ubiquitination promotes clr4 methyltransferase activity for the methylation of H3K9 (PubMed:31468675).  H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci (PubMed:16024659, PubMed:8138176, PubMed:7851795, PubMed:10766735).  Rik1 is involved in the RNAi-mediated targeting of ClrC to heterochromatic repeat elements (PubMed:17114925, PubMed:18345014).  Rik1 has also a function in meiotic telomere clustering (PubMed:15197176).
What are the official names of this protein?
Chromatin modification-related protein rik1, Silencing protein rik1.
What is the protein family that this protein belongs to?
Belongs to the DDB1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Chromosome.
Protein: PUB13_ARATH
Sequence: MEEEKASAAQSLIDVVNEIAAISDYRITVKKLCYNLARRLKLLVPMFEEIRESNEPISEDTLKTLMNLKEAMCSAKDYLKFCSQGSKIYLVMEREQVTSKLMEVSVKLEQSLSQIPYEELDISDEVREQVELVLSQFRRAKGRVDVSDDELYEDLQSLCNKSSDVDAYQPVLERVAKKLHLMEIPDLAQESVALHEMVASSGGDVGENIEEMAMVLKMIKDFVQTEDDNGEEQKVGVNSRSNGQTSTAASQKIPVIPDDFRCPISLEMMRDPVIVSSGQTYERTCIEKWIEGGHSTCPKTQQALTSTTLTPNYVLRSLIAQWCEANDIEPPKPPSSLRPRKVSSFSSPAEANKIEDLMWRLAYGNPEDQRSAAGEIRLLAKRNADNRVAIAEAGAIPLLVGLLSTPDSRIQEHSVTALLNLSICENNKGAIVSAGAIPGIVQVLKKGSMEARENAAATLFSLSVIDENKVTIGALGAIPPLVVLLNEGTQRGKKDAATALFNLCIYQGNKGKAIRAGVIPTLTRLLTEPGSGMVDEALAILAILSSHPEGKAIIGSSDAVPSLVEFIRTGSPRNRENAAAVLVHLCSGDPQHLVEAQKLGLMGPLIDLAGNGTDRGKRKAAQLLERISRLAEQQKETAVSQPEEEAEPTHPESTTEAADT
What is the function of this protein?
Functions as an E3 ubiquitin ligase.
What are the official names of this protein?
U-box domain-containing protein 13, Plant U-box protein 13, RING-type E3 ubiquitin transferase PUB13.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: GRC12_ARATH
Sequence: MERVRDLASEKAAVIFTKSSCCMCHSIKTLFYELGASPAIHELDKDPQGPDMERALFRVFGSNPAVPAVFVGGRYVGSAKDVISFHVDGSLKQMLKASNAIWL
What is the function of this protein?
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase.  Reduces low molecular weight disulfides and proteins (By similarity).
What are the official names of this protein?
Putative glutaredoxin-C12, AtGrxC12, Protein ROXY 5.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family. CC-type subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBB3_PEA
Sequence: GQCGNQIGSKFWEVVCDEHGIDPTGRYVGNSDLQLERVNVYYNEASCGRFVPRAILMDLEPGTMDSVRTGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDSKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIAPRGLSMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEEGEYEDEEEEEPEHGYE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-3 chain, Beta-3-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: GT21_ORYSJ
Sequence: MVGARAGRVPAAAAAAAAVLIVAACVFSSLAGAAAAAEVVGGAAQGNTERISGSAGDVLEDNPVGRLKVFVYDLPSKYNKRIVAKDPRCLNHMFAAEIFMHRFLLSSAVRTLNPEQADWFYAPVYTTCDLTHAGLPLPFKSPRMMRSAIQFLSRKWPFWNRTDGADHFFVVPHDFGACFHYQEEKAIERGILPLLRRATLVQTFGQKNHVCLKEGSITIPPYAPPQKMQAHLIPPDTPRSIFVYFRGLFYDNGNDPEGGYYARGARASLWENFKNNPLFDISTEHPATYYEDMQRSVFCLCPLGWAPWSPRLVEAVVFGCIPVIIADDIVLPFADAIPWDEIGVFVDEEDVPRLDSILTSIPIDDILRKQRLLANPSMKQAMLFPQPAQPRDAFHQILNGLARKLPHPDSVYLKPGEKHLNWTAGPVADLKPWK
What is the function of this protein?
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
What are the official names of this protein?
Probable glucuronosyltransferase Os02g0520750.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 47 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: IE61_CHV9D
Sequence: MNPPAYTSTSGSVASTGNCAICMSAISGLGKTLPCLHDFCFVCIQTWTSTSAQCPLCRTVVSSILHNITSDANYEEYEVIFDDEGYNEDAPLQIPEEPGVNVSPQPPVHSTANSASNTALMRSHAQPRVLAPDNSSVFQPSTSSHASFSSGFAPYSQTPPVGASNLEATRVSRSAVITPTTSTGPRLHLSPSSRSVSQRLQTLFGITKLPGVPTEPPAYAQAEAHFGQANGYGQHRGALHGSYPAVLTAQDTSQIPTRLPFRATDRDVMEVLNSHVICSLCWVGWDEQLATLFPPPIVEPTKTLILNYIAIYGVEDVKLKVSLRCLLHDLTVPFVENMLFLIDRCTDPTRISMQAWTWHDTPIRLLSGPIKSPDGGSTSQDTSVSNIHRSPPGGSSTQPSSGRRPGRPKGVKRRLFVDDDTGVSTNESVFPVINAPIHHKNSKLAALPTGSTTDSNERLVVESPGASAEQPSTSGSSPSPSRRRGRKQGIARIEMLTKKVRRK
What is the function of this protein?
RING-finger E3 ubiquitin ligase that degrades host SP100, one of the major components of ND10 nuclear bodies, thereby disrupting the organization of these bodies.  Also plays a role in the inhibition of host NF-kappa-B pathway by blocking the SCF(BTRC)-mediated addition of ubiquitin chains to host IkappaBalpha/NFKBIA, thereby interfering with its degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase IE61, Immediate-early protein 61, IE61.
Protein: YJ7O_SCHPO
Sequence: MNRNRIYDIVQKGSVSILIFGTVGGTVLLGQSYYSHRQRRLAALQEFQQREKIKEEGFAEDEFNQLALK
What are the official names of this protein?
Uncharacterized membrane protein C757.15.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CLIC4_MOUSE
Sequence: MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRRFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK
What is the function of this protein?
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions.  Channel activity depends on the pH.  Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions.  Promotes cell-surface expression of HRH3 (By similarity).  May play a role in angiogenesis.
What are the official names of this protein?
Chloride intracellular channel protein 4, mc3s5/mtCLIC.
What is the protein family that this protein belongs to?
Belongs to the chloride channel CLIC family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus. Cell membrane; Single-pass membrane protein. Mitochondrion. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles (By similarity).
Protein: CSRA2_PSEPH
Sequence: MLILTRRCAESLIIGDGEITVTVLGVKGNQVRIGVNAPKEVAVHREEIYLRIKKEKDEEPSH
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Post-transcriptionally represses the expression of genes controlled by GacA/GacS (PubMed:10570200, PubMed:15601712, PubMed:11807065, PubMed:23635605).  Represses expression of hcnA; alterations in the ribosome-binding site relieve the repression (PubMed:10570200).  Binds specifically to small RNAs (sRNA) RsmX, RsmZ and RsmY; these sRNAs fold into secondary structures with multiple GGA sequence in loops to which the CsrA proteins bind (PubMed:11807065, PubMed:14622422, PubMed:16286659).  Binding to RsmX, RsmY or RsmZ titrates the protein so that it can no longer bind mRNA and repress translation; each sRNA can bind more than one protein (PubMed:14622422, PubMed:16286659).  Required for optimal expression and stability of sRNAs RsmX, RsmY and RsmZ (PubMed:15601712, PubMed:16286659).  Deletion of rsmY or rsmZ alone has no detectable phenotype, but a double sRNA deletion has a marked decrease in production of secondary metabolites HCN, exoprotease AprA, antifungal agent 2,4-diacetylphloroglucinol and protects cucumber plants from fungal infection less well than wild-type (PubMed:14622422).  The triple sRNA deletion has even stronger loss of these phenotypes (PubMed:16286659).
What are the official names of this protein?
Translational regulator CsrA2, Carbon storage regulator 2, Regulator of secondary metabolites RsmA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMD1_GIBM7
Sequence: MPRSWTDIVAEKRAIRDEKLTKCYGENVPSDPRIIAAKDIQALTKLLEARNVTAEAVVLAHIAKAKEAHQRTNCLTEICFDEALEHARELDAFQQEHGRLKGPLHGVPVSLKDQFNLKGLDSTLGYVGRAFHPAASDCVLVKVLKQLGAVILAKTNLPQCILWGETDNPLWGLTTHPMNPEYTPGGSSGGEGTLLALNGSMLGWGTDIGGSIRVPSHMNGLWGFKPSSGRFSYEAVAVSQDGQQQIPSVVGPMARTLSTITLASKAMIEAECWRLDPQLPPMPWRKDVFQEYLQKPLVIGIMVDDGTVKVHPPIERVFKEFCKKLEAAGHELVPWDTSLNADCIKIMDEHYIADGGEDIRRDMAAGGEPYMPHVQNLVDRGSAISVYEYWQLNKRKKATQAAYNTMWNATKSSSGKPVDVLLVPTMPHTAIPHRTLRYPGYTKLFNMLDYSALSFPAGTALKALDSVCTGEYEPRNAADAWNWSLYDIEKMDGYSVGLQIVGRRMEEEKVLGAAHQVQQLL
What is the function of this protein?
Amidase; part of the Fusarium detoxification of benzoxazolinone cluster 1 (FDB1) involved in the degradation of benzoxazolinones produced by the host plant (PubMed:19302487, PubMed:26808652).  Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).  The first step in the detoxification of benzoxazolinones involves the hydrolysis of the cyclic ester bond of benzoxazolinones by the FDB1 cluster gamma-lactamase MBL1 to aminophenols (PubMed:26808652, PubMed:12788712).  MBL1 is able to convert BOA into 2-aminophenol (2-AP), as well as MBOA into 5-methoxy-2-aminophenol (2-AMP) (PubMed:26808652, PubMed:12788712).  The FDB2 cluster N-malonyltransferase FDB2/NAT1 then metabolizes aminophenols via N-malonylation to non-toxic malonamic acids (PubMed:19302487, PubMed:12788712).  FDB2/NAT1 converts 2-AP into N-(2-hydroxyphenyl) malonamic acid (HPMA) and 2-AMP into N-(2-hydroxy-4-methoxyphenyl) malonamic acid (HMPMA) (PubMed:19302487, PubMed:12788712).  The duplicated dienlactone hydrolases DLH1 and DLH2 may provide redundant function for hydrolyzing the lactone moiety in the BOA molecule (Probable).  The roles of the amidases an other enzymes encoded by the 2 FDB clusters have not been identified so far (Probable).
What are the official names of this protein?
Amidase 1, Fusarium detoxification of benzoxazolinone cluster 1 protein AMD1, FDB1 cluster protein AMD1.
What is the protein family that this protein belongs to?
Belongs to the amidase family.
Protein: HUTI_STRGG
Sequence: MTTTAVTHIASLVTNDPSLGNGTPLGLIQDAAVVIDGDRIVWTGESSKAPATDNVLDAAGRAVVPGFVDSHSHLVFAGDRTQEFNARMSGQPYRAGGIRTTVAATRAASDEELSANVARYLAEALRQGTTTFETKSGYGLTVEDEARALRIAGRHTDEVTYLGAHIVSPDYADDPAGYVDLVTGPMLEACAPHARWIDVFCEQGAFDGDQARAILTAGRAKGLHPRIHANQLTYGPGVQLAVELDAASADHCTHLTDADVDALGQGDTVATLLPGAEFSTRATWPDARRLLDAGATVALSTDCNPGSSFTSSVPFCIALAVRDMGMTPDEAIWSATAGGAAALRRTDIGRITPGARADLVLLDAPSHVHLAYRPGVPLVSAVWRSGQRVV
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_NOVAD
Sequence: MARPVHPEFDKKKVVAENRRARFEYFIEETYEAGICLTGTEVKSLRFGEGSIAESYAEVKNGEVWLVNSNVPEFSHGNRFNHVPKRPRKLLLKERQIAKFTGAVERKGMTLVPLSIYFNSRGRAKVELALAKGKNAADKRTTIKERDWKREKARIMKDHG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.