PharMolix/UniProtQA huggingface dataset:
Protein: SORR1_PENRW
Sequence: MRRQQSGLACEECRRRKARCDRVRPQCGICADAGRTCIVVDKRSPRGPKKGQLKDLRYRLDGTIGCDMDELQMLNFASSESISASDGQEAIDWTLAYDCREERSGTWNHLDISNPRPCIITPISPIQTSASEMTPKGELDMSDLMQADLDLLYFERVHPIVPMIHKRRYLSWANEKTVSPARACLRSAMRTIAAAMSAQFCAFSDKLYACTRSMLEMQDVQGENGLPWMTTTRASRRRIEHEMIQAWLLLAHCEFLRKPEQDALLASTRAVRLLQLSRLFDIDMHDDETSPNENSGSCPSVSPSTTQNLPDEAWIETEEKRRTLWTAFVLDCLSSMLSDRPSMLHEEMINTRLPMPERDFQGGQRPTPMGFLPETMGKTGDCETLSSFAQCVVLANLFGRCIAHRRLAQSVSFPESGSESKSRQFWMRHEWLAAAAAHATRTMPPTQAPNECKSETTKCDPLAAFNRILAYSACISLSETAEARAWETLDDHTLALSYRQVASQAAYEIALLIQKAPRIAFFKMHPVLPNAIYLAARFLRTTTPHFATPAEHDHNSIHHLLVALGYLSSVNNLARDLLVKAEADVGKSARIATEVTGSNWDALMGDTSRHIGMMETSISV
What is the function of this protein?
Transcription factor that acts as the main regulator of the gene cluster that mediates the biosynthesis of sorbicillinoids, a diverse group of yellow secondary metabolites that restrict growth of competing pathogenic fungi but not of bacteria (PubMed:28618182).
What are the official names of this protein?
Sorbicillinoid biosynthetic cluster transcription factor 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: NADK_TOLAT
Sequence: MSQAFRTLALLGKANNDDVNQTINALYKFLREQNYNVLTETRLAHQLPCPAEHCMDIVELGKNADLAIVVGGDGHMLGAARVLARYDVPVIGVNRGNLGFLTDLSPHDFEVSLQQVLSGDYQTEHRFLLETTIYRHGEPKSSNTALNEAVLHPGKIAHMIEYSVYIDDSFVFSQRADGMIVSTPTGSTAYALSAGGPILMPQLDVMTLVPMFPHTLSCRPIVIDAHRQVKLVISPDNPDEQLHVSCDGHVTLSVHPGDEIIIRRAPHQLTLLHPKDYDYFNVLRTKLGWSNQLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPSE2_ARATH
Sequence: MGFNVVVFLSCLLLLPPVTFGSNMERTTLVIDGSRRIAETDENFICATLDWWPPEKCNYDQCPWGYASLINLNLASPLLAKAIQAFRTLRIRIGGSLQDQVIYDVGDLKTPCTQFKKTDDGLFGFSEGCLYMKRWDEVNHFFNATGAIVTFGLNALHGRNKLNGTAWGGDWDHTNTQDFMNYTVSKGYAIDSWEFGNELSGSGIWASVSVELYGKDLIVLKNVIKNVYKNSRTKPLVVAPGGFFEEQWYSELLRLSGPGVLDVLTHHIYNLGPGNDPKLVNKILDPNYLSGISELFANVNQTIQEHGPWAAAWVGEAGGAFNSGGRQVSETFINSFWYLDQLGISSKHNTKVYCRQALVGGFYGLLEKETFVPNPDYYSALLWHRLMGKGILGVQTTASEYLRAYVHCSKRRAGITILLINLSKHTTFTVAVSNGVKVVLQAESMKRKSFLETIKSKVSWVGNKASDGYLNREEYHLSPKDGDLRSKIMLLNGKPLVPTATGDIPKLEPVRHGVKSPVYINPLSISFIVLPTFDAPACS
What is the function of this protein?
Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme.  Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans (By similarity).
What are the official names of this protein?
Heparanase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 79 family.
What are the subcellular locations of this protein?
Lysosome membrane; Peripheral membrane protein. Secreted.
Protein: HFLD_XANCP
Sequence: MSSSMDHRVLALAGVAQALQQVRRIAETGHSEAATVRTAVDSVFRVDAATPEGVYGSSADVAPGLRLLHNYFTNQGKDDMLPRLALAVLQLERRFVRDHSTVETVSKGIEAAARQAQTLGDSAHPDVLSALGALYAQTISHLRPKVMVQGNPHYLGQAGVVAEIRALLLAAVRSAVLWRQMGGSLWDFLFAKRAMIEAVARALR
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: EFG2_POLSJ
Sequence: MTRKTPIERYRNIGISAHIDAGKTTTTERILFYTGVNYKLGEVHEGTATMDWMEQEQERGITITSAATTAFWKGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYDSVGGVQPQSETVWRQANKYKVPRIAFVNKMDRVGADFFRVQRQIGERMKGVAVPVQIPIGAEDHFQGVVDLVKMKAIVWDDISQGLHFEYRDIPDELLATARTWRDKMIEAAAEASEPLLEKYLAGEALSEDEIRQGIRQRTVANEIVPMLCGSAFKNKGVQALLDAIIDYLPSPVDVPAILGHTEDDKTAERHPGDNEPFSALAFKVMTDPFVGQLIFFRVYSGVVKTGDTVYIPGKTRKERLGRLLQMHANVRQEIKEVHAGDIAAAVGLKDVTTGDTLCDPDKVIMLERMVFPEPVISQAVEPKTQADQEKMGVALHRLAQEDPSFRVQTDEESGQTIISGMGELHLEILVDRMKREFGVDATVGKPQVAYRETIKQAVKDVEGKFIKQSGGRGQYGHAVLNVEPQPPGKGYEFVDAIKGGVVPREYIPAVDKGIQDALTAGVLASYPVVDVKATLVFGSSHDVDSNENAFRMAGAIAFREALRRARPILLEPMMAVEVEMPEDFMGHVMGDLSTRRGMIQGMEDIAGGGGKLVRAEVPLSEMFGYSTTLRSLTQGRATYTMEFKHYTEAPADVSEAIIRGKGMGRQ
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 2, EF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOA_SHISS
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCKIIAIDNSPAMIERCSRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHKAGFEHSELWFQCFNFGSLVALKAEDAA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: RAP1B_PANTR
Sequence: MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQLL
What is the function of this protein?
GTP-binding protein that possesses intrinsic GTPase activity.  Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen.  Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.  Plays a role in the establishment of basal endothelial barrier function (By similarity).
What are the official names of this protein?
Ras-related protein Rap-1b.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol (By similarity). Presence of KRIT1 and CDH5 is required for its localization to the cell junction (By similarity).
Protein: RNPH_SULSY
Sequence: MRPDGRKPAQLRPIKIIRDFNIYAEGSVLIEFGNTKVIVTASVEDKVPPFLKGTGQGWITAEYSMIPRASETRSLREVVRGSPSGRTHEIQRLIGRSLRAAVDLKKLGEKTIWIDCDVIQADGGTRVASITGAFIAVADACIKLTKQNLVKANPLKDYVAAISVGKVRNEIVLDLNYTEDSNAQVDMNLVMTGKGEFVEIGATGEENTFSQEDFNKMLEYGKSGIERLIKIQKEFIEGIPSIGHWERKNIKEFVYKE
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: CAP9_ADE07
Sequence: MSGSASFEGGVFSPYLTGRLPPWAGVRQNVMGSTVDGRPVQPANSSTLTYATLSSSPLDAAAAAAATAAANTILGMGYYGSIVANSSSSNNPSTLAEDKLLVLLAQLEALTQRLGELSKQVAQLREQTESAVATAKSK
What is the function of this protein?
Structural component of the virion that acts as a cement protein on the capsid exterior and forms triskelion structures consisting of three molecules that stabilize three hexon trimers at the center of each icosahedral facet and fixes the peripentonal hexons.  Dispensable for assembly.  During virus entry, recruits the anterograde motor kinesin-1 to the capsid docked at the nuclear pore complex thereby subjecting the docked capsid to a pulling force.  The resulting tension leads to capsid disruption, dispersion of capsid fragments toward cell periphery and eventually viral DNA entry into the host nucleus.
What are the official names of this protein?
Hexon-interlacing protein, Protein IX.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae hexon-interlacing protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Located in the canyons between the hexons on the outer surface of the capsid. Forms a sort of hairnet on the outer side of the virion. Present in 240 copies per virion.
Protein: GPH_XANCP
Sequence: MRFPRAVLFDLDGTLLDSAPDMLATVNAMLSERGLPCITLAQLRPVVSKGSRAMLAVAFAHLDAAAREALVPEFLKRYEALLGTQAQLFDGVEVMLQRLEQAGCVWGIVTNKPEYLAQLILPQLGWQQRCAVLIGGDTLAERKPHPLPLLVAADRIGVAATQCVYVGDDERDILAARAAGMPSVAALWGYRLGDDDPLSWQADVLVEQPPQLWEPAAWPQP
What is the function of this protein?
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.  Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: Y868_METJA
Sequence: MISKYLVRDVMKKGVVEVTLDTKLSDVIKTMAKYDISSVVVSDGETFWGIITDTDVLKHYNDLDKTAEEIMTTNPITVSPEAPLEKAVEIMAEKGIHHLYVKSPCEDKIVGVLSSKDIIKLFSDLIE
What are the official names of this protein?
Uncharacterized protein MJ0868.
Protein: Y1353_MYCBO
Sequence: MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT
What are the official names of this protein?
Uncharacterized protein Mb1353c.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HTPX_ARTS2
Sequence: MHNHHNGLKTAALFGVLWAVLLGLGAVIGSSMRSTTPIWIMALVGVGTTAYGYWNSDKLALRSMQAYPVTEEQAPQLYQIVRELSAKANQPMPRIYVSPTPAPNAFATGRNPQNAAVCCTEGILRLLSLRELRGVLGHELMHVYNRDILTSSVAAAVAGVITSVGQMLLIFGGGDRRNSNPLAVMAMALLAPLAAVVIQSAISRTREYDADEDGSALTGDPLALASALRKIHQGVQMVPLPPDQKLVNTSHLMIANPFRAGGVTRMFATHPPMQDRITRLELMAGGPAS
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IGF1A_XENLA
Sequence: METNNNLSTQLFKCYFCDILKLKMHKMSCIHLLYLVLCFLTLTHSAAAGPETLCGAELVDTLQFVCGDRGFYFSKPTGYGSNNRRSHHRGIVDECCFQSCDFRRLEMYCAPAKQAKSARSVRTQRHTDMPKAQKEVHPKNTSRGNTGSRGFRM
What is the function of this protein?
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.  Promotes head development by inhibiting Wnt signaling during embryogenesis (PubMed:11709186, PubMed:11944947).  Acts as a ligand for IGF1R.  Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways.  Binds to integrins.  Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling (By similarity).
What are the official names of this protein?
Insulin-like growth factor I-A, IGF-I', IGF-IA, xIGF-1, Somatomedin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: URED1_BRUA2
Sequence: MLIINDNNLSGLSLQRVNGTGELSVQFKDGRSRISRLYQEGAAKIRMPQAVTGPLEAILINTSGGLTGGDRLKWDVALDDGASAVITTQACERIYRSGGGEARIATRLKAAKGTRLAWLPQETILFNRSILSRRLDVELEEGAQMLVVEATVFGRLAMGERVVAARFADRWRVRLGGRVIHAEEFRLGPDVGAELQAPAVAGGACAMATVLMVCEQAGRYLETARAIIGEEGGCSLWRVGKASKLVVRLYAPDSYALRRRLCPLVALLNGKAGLPKVWTI
What is the function of this protein?
Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach.  The major route of infection in human brucellosis is oral.
What are the official names of this protein?
Urease accessory protein UreD 1.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCOP6_ARATH
Sequence: MGTKCYSKLRYVVVLVLLLFVFPCSLSQSAPSSVTGRRLMGIYMPNGGIIAGSSPSGQAPNINNNYHGRRLMISEARPSKSKKGGGREPESPG
What is the function of this protein?
Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including growth prevention and reactive oxygen species (ROS) response regulation (PubMed:33514716, PubMed:34535661).  Inhibits root growth (PubMed:34535661).
What are the official names of this protein?
Serine rich endogenous peptide 6, AtSCOOP6, Phytocytokine SCOOP6, Precursor of serine rich endogenous peptide phytocytokine 6.
What is the protein family that this protein belongs to?
Belongs to the serine rich endogenous peptide (SCOOP) phytocytokine family.
Protein: RNC_PHEZH
Sequence: MNARAAAVAELERRIGYVFTDRDLLERALTHASVGDGARAVRHNERLEFLGDRVLNLCAAERLMALDPDAREGEMSRLLASLVNYHACARAAKRAGLQEALRLSASATKVGARKSDAVLGDACEALIAALYIDGGLETARAFFLKFWDEEFARLDEPRAKDPKTQLQEWVQGMGLPLPTYEIVSQEGPPHAPSFTVEVQVAGFGAERGEGRSRQAAEKAAAQCMLLKREGPEPGKVGE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_SALNS
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEIVAKLFNELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRSEKTEAAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: YCX1_PINTH
Sequence: MGFVDMDYDIISYSDQMPLAQHYSYFIIYSPSKSRFHVIPYKDDEYLNRFYWLQISLGFSIDASNISSQYSANPTINLSLILD
What are the official names of this protein?
Uncharacterized 9.7 kDa protein in chlB-trnK intergenic region, ORF 83.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PLSX_STRZJ
Sequence: MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQYLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGALLAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAKNVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVVADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLSGLKKQLNYSDVGGAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: SGO1_HUMAN
Sequence: MAKERCLKKSFQDSLEDIKKRMKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVLALENEKSKVKEAQDIILQLRKECYYLTCQLYALKGKLTSQQTVEPAQNQEICSSGMDPNSDDSSRNLFVKDLPQIPLEETELPGQGESFQIEDQIPTIPQDTLGVDFDSGEAKSTDNVLPRTVSVRSSLKKHCNSICQFDSLDDFETSHLAGKSFEFERVGFLDPLVNMHIPENVQHNACQWSKDQVNLSPKLIQPGTFTKTKEDILESKSEQTKSKQRDTQERKREEKRKANRRKSKRMSKYKENKSENKKTVPQKKMHKSVSSNDAYNFNLEEGVHLTPFRQKVSNDSNREENNESEVSLCESSGSGDDSDDLYLPTCKYIQNPTSNSDRPVTRPLAKRALKYTDEKETEGSKPTKTPTTTPPETQQSPHLSLKDITNVSLYPVVKIRRLSLSPKKNKASPAVALPKRRCTASVNYKEPTLASKLRRGDPFTDLCFLNSPIFKQKKDLRRSKKRALEVSPAKEAIFILYYVREFVSRFPDCRKCKLETHICLR
What is the function of this protein?
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.  May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase.  Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A.  Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore.  Necessary for kinetochore localization of PLK1 and CENPF.  May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity.  Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.  Involved in centromeric enrichment of AUKRB in prometaphase.
What are the official names of this protein?
Shugoshin 1, Serologically defined breast cancer antigen NY-BR-85, Shugoshin-like 1.
What is the protein family that this protein belongs to?
Belongs to the shugoshin family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase (PubMed:16541025). Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A (PubMed:16580887)(PubMed:16541025)(PubMed:15604152). Colocalizes with NEK2 at the kinetochore (PubMed:17621308). Colocalizes with and SS18L1 at the kinetochore (PubMed:16582621). Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore (PubMed:17617734). Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis (PubMed:16582621). Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent (PubMed:16582621). Isoform 3 does not localize to kinetochores during any stages of the cell cycle (PubMed:16582621).
Protein: HISX_SALTI
Sequence: MSFNTLIDWNSCSPEQQRALLTRPAISASDSITRTVSDILYNVKTRGDDALREYSAKFDKTEVTALRVTPEEIAAAGARLSDELKQAMAAAVKNIETFHSAQTLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPARIAGCQKVVLCSPPPIADEILYAAQLCGVQEIFNVGGAQAIAALAFGSESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPDADIARKVAEAVERQLAELPRAGTARQALSASRLIVTKDLAQCVAISNQYGPEHLIIQTRNARDLVDAITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKAGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: RS16_OCEIH
Sequence: MAVKIRLKRMGSKRNPFYRIVVADSRSPRDGRSIEQIGTYNPVVNPVEVKIDEEKALDWMSKGAKPSDTVRNLFSNEGIMKKFHEQKNSK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RPAB1_CAEBR
Sequence: MADDELETYRLWRIRKTVLQMVHDRGYLVAQEELDQPLETFKETFGDRPSEKKPARSDLTILVAHNDDPADQMFVFFPEDTKIGIKTIKAICQQMQEQNISRAIIVVQTGMTPSAKQSIGDMAPKYMLEHFLEAELMVNITEHELVPEHVVMTAEEKAELLARYKLKDSQLPRIQQCDPVARYFGLRRGQVVKIIRPSETAGRYITYRLVV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  Pols are composed of mobile elements that move relative to each other.  In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template.  Seems to be the major component in this process (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerases I, II, and III subunit RPABC1, RNA polymerases I, II, and III subunit ABC1, RPB5 homolog.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: G1PDH_CENSY
Sequence: MPGGRDPMPSHTMELPRLIVIGEGNMGDLGPFLGSLGGPRTVSLISGRTVQGATGRKIEGSLKRSGIKWSWHMAGTNDPESIASVQEAVRSDESGMAVGIGGGRAVDTAKMAAFKLGIPFVSVPTAASHDGIASPFVSIKGDKPHSITATAPLGVFVDIGVIRKAPARLLASGCGDLVANMIAVRDWELGRDRKGEYYGRYAASLALMSAKIVMENAARFAREGVDERVVVEALISAGVASCIAGSSRPCSGAEHLFSHALDRIAPGAGLHGEKCGIGSIMMAKLQGQDWKGIAGALKSVGAPTTARQIGLDREDLIEALMTAQGLRPERYTILEEAGMSRRRAAALARVTGVA
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_METSB
Sequence: MAKVIGIDLGTTNSCVAVMEGTTPKVIENAEGARTTPSIVAFTDDGERLVGQPAKRQSVTNPERTFFAIKRLIGRTYDDPMTKKDMGLVPYKIIRASNGDAWVEADGKQYSPSQISAFILQKMKETAEAYLGQPVSQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKKGAGVIAVYDLGGGTFDVSILEIGDGVFEVKSTNGDTFLGGEDFDVRLVEYLADEFKKENGIDLKKDKLALQRLKEAAEKAKIELSSATQTEINLPYITADATGPKHLTLKLTRAKFEALVDDLIQKTVEPCRKALKDAGLTAGEINEVVLVGGMTRMPKVQEVVKSFFGKEPHKGVNPDEVVAIGAAVQAGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRLIDRNTTIPTKKSQVFSTAEDNQTAVTIRVFQGEREMAADNKLLGQFDLVGIPGAPRGVPQIEVTFDIDANGIVNVTAKDKATNKEQQIRIQASGGLSEGDIDKMVKDAEVHAAEDKKRRELVDARNQAEAMVHSAEKSLTEFAGKVSDADKSALEAAIASVKGVLEGEDVEAIKARSNDLAQASMKLGEAMYKAGAEAGPQEGGGAEKDDVIDADFKEVGPDDKKKSA
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.