PharMolix/UniProtQA huggingface dataset:
Protein: OPTN_MOUSE
Sequence: MSHQPLSCLTEKGDSPCETPGNGPSNMVHPSLDTFTPEELLQQMKELLVENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERLLFEMQSKEVKERLKALTHENERLKEELGKFKEKSEKPLEDLTGGYRYPRALEEEVEKLKTQVEQEVEHLKIQVMRLRAEKADLLGIVSELQLKLNSGGSSEDSFVEIRMTEGETEGAMKEMKNCPTPTRTDPISLSNCTEDARSCAEFEELTVSQLLLCLREGNQKVERLEVALREAKERISDFEKKANGHSSTEKQTARRADREKEDKGQESVGSEVETLSIQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSATPSELNEKQELVYSNKKLELQVESMRSEIKMEQAKTEEEKSRLATLQATHNKLLQEHNKALKTIEELTKQQAEKVDKMLLQELSEKLELAEQALASKQLQMDEMKQTLAKQEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNDIEEGGSRQSLMEMQCRHGARTSDSDQQTYLFQRGAEDRSWQHGQQPRSIPIHSCPKCGEVLPDIDTLQIHVMDCII
What is the function of this protein?
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8.  Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation.  Plays a role in the activation of innate immune response during viral infection.  Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation.  In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta.  Plays a neuroprotective role in the eye and optic nerve.  May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD).  Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment.  Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
What are the official names of this protein?
Optineurin.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3- positive cytoplasmic vesicles upon induction of autophagy (By similarity).
Protein: GLGC_AROAE
Sequence: MIAGKSVLAFVMAGGEGSRLHPLTAERSKPSVPFNGRHRIVDFVLSNLVNSEIYSIYLLVQYKSQSLIEHTRRAWVMSPLLPHHFVTVVPPQMQHGPEWFQGTADSVYQNLHLVELVKPDLVVVFGADHVYRMDLRQMIEFHIATQADATVAALPVPLEHTSSFGIIRTDSAGRIRDFREKPESAEPMPGRPGHALASMGNYVFSADLLVDALRRAHSRGGHDFGKNLLPAMAERNRVMAYDFTTNRMRGIRDYEEPAYWRDVGTIDAYYDANFDTLGEFPKFCMSNPHWPIYANPDQTEAAQVHDGHIRTASLGAGVVIRRAVIERSLLRREVVVEEGAEVVDSIIMDRSVIGKGARVRRAIIDQYNFVPPGMKIGYDPEADRQRFHISESGVVVVGKGQLKP
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: MAP2_LACBS
Sequence: MSACTSFLRVAGDKVNLSFSSNSWRTTSEEKRYDERMANEDPEKTYQSIRRAAEVHRQVRQHARRHIRPGMTMTEIANNIEDGTRALVEEDGLLSGVGFPTGLSLNNCAAHYTPNAGDTTVLQKGDVLKVDIGVHVKGRIADSAFTLTWEPTYNKLLEAVKAATDTGIRESGIDARLGEIAGAIQETMESYEVEVNGTVYPVKPIENLSGHSINPYQIHGGKSILLVKNDDQTKMEEGEYFAIETFGSTGRGRIVESGEVSHYARRMDAPHVPLRLTSAKTLLKSINKNFGTLPFCRRYLDRAGESKYLLALNHLVGQGIVQDYPPLCDQRGSMTAQFEHTILLRPTVKEVVTRGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2, MAP 2, MetAP 2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBX_MUSDO
Sequence: NSYFEQASGFYGHPHQATGMSMGTAGHHDQSATAAAAAYRGFPLSLGMTPYTNHHLQRSTQDSPYDASITAACNKIYGDGNAYKQDCLNIKSDTINGYKDIWNTTANGGGAGGGGGTGGGGGGSAGSANGANNTANGQNTSGGGGAGGGGGMPVRPSACTPDSRVGGYLDTSGGSPVSHRGGSAGVVGGAGTGVGQSGQSANVGGAGGVGGATAWNANCTISGAAAAQTASSLHQASNHTFYPWMAIA
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Binds the consensus region 5'-TTAAT[GT][GA]-3' (By similarity).
What are the official names of this protein?
Homeotic protein ultrabithorax.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRMB_CHRVO
Sequence: MENPAFKRAIRSFVLRQGHLSAGQQRAMDEGMPKWGIEYRPETMDLEQVFGRAAPKILEIGFGMGGATAEIAAANPDNDYLGIEVHGPGVGNLCKLIAEKELTNLRLMRHDAVEVLDNMLADGSLDGVHIFFPDPWHKKRHNKRRLIQAPLVEKLAKKLKPGGYFHAATDWEDYAIQILEVLNGNADLENTADGYAPRPDYRPLTKFEARGIKLGHGVWDVIFRRK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: PIRT_MOUSE
Sequence: MEVLPKALEVDERSPESKDLLPSQTASSLCISSRSESVWTTTPKSNWEIYHKPIIIMSVGAAILLFGVAITCVAYILEEKHKVVQVLRMIGPAFLSLGLMMLVCGLVWVPIIKKKQKQRQKSNFFQSLKFFLLNR
What is the function of this protein?
Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin.  Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2).  Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI).
What are the official names of this protein?
Phosphoinositide-interacting protein.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DEOC_GLAP5
Sequence: MSLKSIAKQALSLMDLTTLNDNDTDEKVVTLCQQGNTLFGTPAAVCVYPRFIPIARKTLKAQGAEQVKIATVTNFPHGNDDIDIAVAETKAAVAYGADEVDVVFPYRALIAGNEQVGFELVKQCKAVCSANNVALKVIIESGELKTAELIRKASEISIKAGADFIKTSTGKVPVNATLESAHIMLETIRDLGVADSVGFKAAGGVKTTEEAEQYLALTAEILGQDWINQAHFRFGASSLLANLLATLNDEQVNQNVTGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJQ3_YEAST
Sequence: MSNEDETTRLMSSDEMDYLLETAGINALEEIISQNDSTGINLDTNETAQDSSYDSIRRSPSILSVAKSVEGEHGRRKLLCLYGLVMIICIAESISMTATIPLVMDKVAEGISDENGHYDSVAVQTIVSSISSSTMMIAGAISIFMAGKWGELSDRIGRVRVFKYMSGIRVIGLLTHVFTLSSKMKYHKWAIVLTACIVPSFGGLFALVANGNSYVSDIVKTEHRMVTIGIMMSCIYATMGVGPMFGSFLVKWTHGNGFIPIYTSIAFVILALIICETIMVEPRHETQMAHSQSTYTKRREKLRSQSGSDDARNYQSVTYGKFQIMRLMDLLAPVKKLWLKPDSAGSLVPRHTVILLIVLDILFVCGTTSCMPALILFSTYEYKWHAVELGYFISILGIGRGVVLLVVSPTLLYTLKRIYQHLNHSIDKIDIFCIQFSMIVITLSLFVMIRFGEKTPTSMIIFALLQALSAFCSPTLQSGIIKYTSKKHTGEMFGAMALVRSCVMLVIPPILLKLYGSTVSVNPSLFMYIPFSTSIVAILLTFFLRIYKNPPLDGP
What are the official names of this protein?
Uncharacterized membrane protein YJL163C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ERGO1_CAEEL
Sequence: MSYNNGGGGGGGGYRNDRDDRYHNNDRQNYRSSDQGRSGYNDDRRDNRYDDRRGSNNDRGCYDQHDRRGSSNDDRRGYRGYNQGGGGYQQQYSQDARYGSNQRNDNYGNNRGSHGGANMYSQNGGNRGGGGGRVGGGRTAAGMSNPGDLVGGADQPIHSVSKKSLRHNAQEFAVRPKTMVQDKGLGQKTTLLTNHTLVQLPQEPITLHVFNIEVFINGKSSNKRELCGPRFWEILKENKPTFGMPNQYIFNDVNMMWSTNKLRQSEGRTNNRRMNFVWKYVKQIKFGGNIEDEETMQLLSTLIDAIATQRARLPLAPPKYTVFKRLTYLICEEAYEPELPDVSLCHKLRIGTDARVGVSIAIRTNLRAGITACFDLGHTLFTRPAYPLVRLLCDIIEHSVVLDEAFEMKYDAALRACNVSDENLRVMTQILTKMTLQLSTETGDYVGEDGEVIVRPAPTIRNPGRNFKFVGLGAPADRYYFTSDGVELTVADYYLQKYNIRLRYPNLPCVLKKAPEQCGNKHSAMPLELVSYIVVPTRYGGFTMPDMRADMINKTTYTAQQRGKLLQHIIAQKSLSGIEPPVSNNDDYMKKHKLVMKREPIRVKATILPPPTLVYGDSVFHDEHHIGEWEAVTHDPPRQVLDGAVFRRKLYKSSEQPLMKRLMGSILLIQSPRQCRDFDYNQQGYHAIMRAIEDSGQPVLWADENKHSAVIQGELQFNQNQHGIEVIEQFLQNIKSTIGEYERDGEVIVPIVFAVFQARATVYSGNNNEYNDYNVLKYLADNKYGIHTQGILEKSLGVVGPSPKNCALTRLMVEKVLGKVGTTHRKLERGGAHKTWTIFTDPAKPTLVLGIDVSHPSTRDRETGNVLQKMSAATVVGNIDLDVTEFRASSRIQDTGVECLIDFSKEIDERIGEFIDHTGKRPAHIVVYRDGLSEGDFQKYLFEERVCIEERCLKIDTSFQPSITYIVVTKRHHTQFFLEDPSQGYESQGYNVLPGTLIEDAVTTNKYYDFFLSTQIGNEGCFRPTHYYVLHDTWTGKPDSFWPTVTHALTYNFCRSTTTVALPAPVLYAHLAAKRAKETLDGINTYKSVNNIYCDLESFGDLCEVNKDMNVNEKLEGMTFV
What is the function of this protein?
Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway (PubMed:17110334, PubMed:20133583).  Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G-siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end (PubMed:22102828, PubMed:22548001).  Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs (PubMed:22548001).  Association with 26G-siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guanine residue at the 5'-end) (PubMed:22102828).  May be involved in passenger strand cleavage of target 26G-siRNAs (PubMed:22102828).
What are the official names of this protein?
Piwi-like protein ergo-1, Endogenous RNA interference deficient argonaute protein 1.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Piwi subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UMPS1_ORYSJ
Sequence: MDAAAQESLILELHAIEAIKFGTFVLKSGITSPIYLDLRALVSHPGLLSSIATLLHTLPATRPYDLLCGVPYTALPIASVLSVHRSVPMVMRRKEAKAHGTAKSIEGAFRAGEAVLIIEDLVTSGASVLETAAPLRDQGLVVADAVVVVDREQGGRENLAANGITLHSLMTLTEVLAVLLKHGKVTEEKAREVRQFLDANRKVTVPGAAGAVKPKAVRKGFAERAGLAKNPMGKRLFEVMEAKQSNLCVAADVGTAKELLELAEKVGPEICMLKTHVDILSDFTPDFGAKLCSIAEKHNFLIFEDRKFADIGNTVTMQYEGGIFRILDWADIVNAHIIPGPGIVDGLKLKGLPKGRGLLLLAEMSSAGNLAHGEYTAAAVKIAEQHSDFVIGFISVNPASWSVAPSSPAFIHATPGVQMVSGGDALGQQYNTPHSVINDRGSDIIIVGRGIIKASNPAETAREYRIQGWGAYQSSLP
What are the official names of this protein?
Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the OMP decarboxylase family.
Protein: RL352_ENCCU
Sequence: MKIEASALRQLGIKQIEERAAEIKAELAALRQKKNSGDVGANDIKTAKKNLARALTVRREKILEELVEAYRGTPVSKLPKELRPKLNRSKRRALTKTQLRRKTRRQRARMSKFPRVIFAYNE
What are the official names of this protein?
60S ribosomal protein L35-2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPHN_DROVI
Sequence: MGLHFYECNLSVQRKRVCSLEKRQMKAPKYQTAYACEGKKLTIECEPGDLINLIRANYGRFSITICNDHGNVEWSVNCMFPKSLTVLNSKCSHKQSCSVLAATSMFGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIQAPPPPPPRLPSLPGVVGIHGINAVPPTHSTPSSSTATLPGGRLKGVTSATTKHPGGRHDGLPPPPQLHHHHHHTDETVPTKSSSSGSTGNVTSPSNTRILTGVGGAGSDDGTLLTTKSSPNRTPGTVASTTNSSLSIGGTGAGGVVRTINNINLNAAGMGTDDESKLFCGPTHARNLFWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRLPDAGYDEYDDDLPVASSTTPIPPSSAGDCLHNSSSCEPPVSMAHKVNQNQRLRNFEPTWHPLTPDLTQCRSLWLNSLEMRVNQRDSSLISIANDLSEVTSSKTLYGGDMLVTTKIIQTMSEKMLHDKETFPDQRQREAIIMELLHGVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERNVVQKVKNILLSVRVLETKTIHGSVVFPDSDQWPLSSDRIELPRSALIENSEGGLVRIVFAAFDRLESILKPSYDHFDLKSARSYVRNTAILSNDSDAATGDMQQRIRILNSKVISASLGKGRHIQLSHPITLVLKHLKTENVSNPTCVFWNYIDHAWSVNGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISVAICVVFIIIALLTLKLFNGVFVKSARTSIYSSIYICLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLWSYGLSLTVVAISLAINPSTYTQNDYCVLMEANALFYATFVAPILIFFVAAIGYTFLSWIIMRRKSRTTLKTKEHTRLANVRFDIRCSFVFLLLLSAVWCCAYFYLRGAKLDEEVATVYGYCFICFNTMLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGVVAGNGGPGVGNVANNSAGTLSKSKSKLPLSATDEARAVEQQQQQKDVPAADDAIIMGAGSDSELNEAQQRRTLKSGLLTGSLQPTPVGAVVLERGTLRSTGMASVGHASPTSSAGSTHLIFAHKQQQQLQQPGEAYYHQPDYYSWKHPQAGQREYYNNTGVTANAGIGGASPSQAHEVFYWTQKHNNQHGKKKRGGNAGAVPASPSGSLHSRVTAASQVLFYPSYKKTSGLKQPPATQAYPHYAEALDPPNAAYYQQQLQQQQLRQQRQQQQQQLSSDEEQAEQHAHLLHLQHQQRRAGGPQLPAPPPHMAQYQQELLAQQQRQQYRNKHSNCDLSQGMGLGKGMGMVLGDAYYNQGGSSNGGGDGGPVYEEILSNRNSDGQHYEVGDFDVDEVYNNSVGTGVFNSMRAAVAAGGNRYCGGSLSGGSVTSRNQQQQQKQKQPPRRCVADDDDDDDDDEYDDEVTAAEQLHDSVCDDEDNDSDIDDDTHGLPPQSDERMRRLMALQDEDFKRRFQRQQRKNGLPLDYGASAQTASINHPEHNGAVFGVSGGVGEGSMRGAYRQQQQQNAKSPSARLAVNELFGHGNAGPPLPPANQTPAQKRQQLQKLSPQSTTSSSSHTSHSNPQHAPAHHIQHQQHHQQQQQARHLSAMLDENNTVRCYLEPLAK
What are the official names of this protein?
Latrophilin Cirl.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRE_MYCTA
Sequence: MAGPDRAELAELVRRLSVVHGRVTLSSGREADYYVDLRRATLHHRASALIGRLMRELTADWDYSVVGGLTLGADPVATAIMHAPGRPIDAFVVRKSAKAHGMQRLIEGSEVTGQRVLVVEDTSTTGNSALTAVHAVQDVGGEVVGVATVVDRATGAAEAIEAEGLRYRSVLGLADLGLD
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: SYFA_CORJK
Sequence: MTDSADTPQVELSEQGLNAAADAAEKAFAEAANLEELAAARREHLGDDAPIPAARRSLGSLPKDQRKDAGRLVNMARGRVEKRFAQVKAELERKRNEEVLRAERIDVTEPTTRGQRGAQHPITILSEQIADIFVGMGWEIADGPEVEAEYFNFDSLNFIPDHPARTLQDTFHIAPEGSGQVLRTHTSPVQMRTMLSRDLPIYIACPGRVFRTDELDATHTPVFHQVEGLAVDKGLTMAHLKGTLDHLAKTLFGEEAKTRIRPNYFPFTEPSAEVDVWFADKKGGAGWIEWGGCGMVNPNVLIAAGVDPEEYSGFAFGMGIERTLQFRNGLPDMRDMVEGDVRFTLPFGVRR
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YVBT_BACSU
Sequence: MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGYHRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLETLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRAIPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVLDEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEKAMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWKNR
What are the official names of this protein?
Uncharacterized protein YvbT.
What is the protein family that this protein belongs to?
To bacterial alkanal monooxygenase alpha and beta chains.
Protein: RL15_THEMA
Sequence: MRLEDLRPTPGAMKKRKRVGRGPGSGHGKTSGRGHKGQKARGSGKVHIWFEGGQTPLQRRLPKRGFKNINKKVYAVVNVKVLEERFEANEEVTPEKLIERKIIKDLKDGVKILGDGELTKPLVVKAHAFSKSAVEKIESAGGKAEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: DXS_PELUB
Sequence: MQNYKFLKDINFPSDLRKLSENDLQEVSNEVRKEMIDAVSETGGHLGAGLGVVELTVALHYVFDTPNDRLIWDVGHQTYPHKILTGRKSKIKTLRQGNGLSGFTKRSESEYDPFGAAHSSTSISSALGMAEANKLSNKLNNIIAVIGDGAISAGMAYEAMNNAGASKTKMIVILNDNDMSIAKPVGAMRTYLAKLLTGKIYFSLRETFKLIVSAFSKRFSVKAGKAEDFLRSAVTGGTLFNSLGFYYVGPIDGHDLSTLIPILKNARDSKHQGPIMIHIKTQKGKGYSYAEKASDHYHGVSKFNVVTGEQVKSGTNLPAYTKVFANTLVKHAERDSKVVGVTAAMPGGTGMDIFAKDFPKRMFDVGIAEQHAVTFAAGLATEGYKPYVAIYSTFLQRAYDQVVHDVAIQSLPVRFIIDRAGLVGADGSTHAGSFDITYLSTLPNFIVMAPSDEAELVKMTNTSMTINNKPCAIRYPRGNGIGVELPSIDENIEIGKGRVIQEGKQVCILSIGTRLEECKIAAAELKNKGIESTIVDARFAKPLDQELILKCAREHEAMITVEEGSIGGFGSHVENLLSEKGIFDKGLKFRTMILPDIFIEQDSPKKMYDVAGLNASQISKKILDILFTKESIKVVKN
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: RS10_YERP3
Sequence: MQNQRIRIRLKAFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHKRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: HILS1_RAT
Sequence: MSLVSPSPDSNAVMAGDQDASTSQVPSQSESKIGPNVATQTLRKPTMSKVILRTVADKGVHSRVSLAALKKAVSITGYNMAQNTWRFKRVLQNLVKKGMLKQVTGKGASGSFRLGKKQAFKSKCKAKRRQRRQKPGQRRTGSRRSLLGSKKSNNRLFKGVRRVAKGRRH
What is the function of this protein?
DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.
What are the official names of this protein?
Spermatid-specific linker histone H1-like protein.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL34_CLOPS
Sequence: MFMTYQPKKRQRSKEHGFRKRMKTKSGRNVLKRRRQKGRKRLTA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RL30_METM5
Sequence: MAYAVVRVRGSVGVRGNIADTMKMLRLHRVNHCVVIPDNEHYTGMIKKVKDYVTYGEIDKDTLVALILKRGRLPGNKRLTEELVKELTELPVEELAEKIIAGEIKIKDTPIKPVFRLHPPRKGYDRAGVKKGFSIGGALGYRSGKINDLLNKMM
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RUVA_MYCBO
Sequence: MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLYGFPDGETRDLFLTLLSVSGVGPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGAERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGFAAKQAEEATDTVLAANHDATTSSALRSALSLLGKAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RLMH_BIFLS
Sequence: MNIDIVCVGRIKERYLTDAIAEYSKRLSRYCKLNIIEVADEKTPEHASEGVGRQIKAKEGERIAKHLKDGAFVIALAINGKQLSSEELAAKINDLGLRGTSHIQLVIGGSIGLDDAILRRADFLLSFSKMTFPHQLMRVILLEQIYRAYKINAHEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICAM1_MACMU
Sequence: MAPSGPQPALPILVVLLGALLLGPGNAQTSVFPPEVILPRGGSVKVNCSASCDQPISLGMETPLPKKEILPGGNNWKMYELSNVQEDSQPMCYSNCPDGQSSAKTLLTVYWTPERVELAPLPPWQPVGKNLTLRCQVEGGAPRANLTVMLLRGEKELSRQSAVGEPAEVTTTVPVGRDDHGANFSCRTELDLRPYVLKLFENTSAPHQLQTFDLPATPPQLVSPQVLEVDTQGTVVCSLDGLFPVSEAQVSLALGDQKLNPTITYGNNSLSAKASVKVTAEEEGTQQLLCGVMLGNQTQETRQTVTIYSFPAPNVNLTKPEVSEGTEVIVECEAHPRAKVMLNGVPAQPPGPRAQFLLKATPEDNGRSFSCSATLEVAGQLVHKNQTRELRVLYGPRLDEKDCPGNWTWPENSQQTPMCQAWGNPLPQLKCLKDGTFPLPIGQSVTVTRDLEGTYLCQARSTRGEVTREVTVNVLSPRYEVVIIPVVAAAVILGTAGVATYLYNRQRKIRKYRLQQAQNGTPMKPNTQATPP
What is the function of this protein?
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).  During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
What are the official names of this protein?
Intercellular adhesion molecule 1, ICAM-1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. ICAM family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: FTMC_ASPFU
Sequence: MKPSHSDTPLMMPSVMKCGYLATAGLIGICTHLSYFRYGEHHLYPWRYVRFHLCLTMGVAALLYAKKPPQYTLCSMDLVKDVSLLMATYLVGLFASLLLYRTLFHPLRQIRGPWAAKISSFWLSFRLRRGPSFRILHELHEEYGPVVRVGPSEVSIIHPEAVRMIYGPNSRCSKNTFYDNGHPMMSLHSYRDRIAHDQRRRVWSAGFGDRALRGYEQRMRVYRQKLFQRLEARAVAESAINISQWFNFYSYDTMGDLAFARSFDMLDASRNHWAVDMLMHGMIGYRYLFPSWFFRLLATMPSLSSDWHKFIGFATDTMLRRVGEQVDVPDIFASLLAPLNGREPTEDERNMLMGDAMLIITAGSDTTATSLTSIVYELARHLDEVDKLRAELDPIEADSDGEYQHDTLAKLPHLNGFINETLRLHPPIPGVIPRKTPPEGIHVKDVFIPGNMTVFSPQWSMGRSEAAYIDPEIFNPERWYKHMDLVKDPSAFAPFSIGPYSCIGKPLALMNIRTTVARLIMSFDVRFPEGEDGIRWMDAADEHFAMGIHQMPVVLTRRH
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities (PubMed:19226505, PubMed:23649274).  The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA (PubMed:16755625).  Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B (PubMed:16000710, PubMed:21105662, PubMed:23090579).  The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively (PubMed:19226505).  The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable).  FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B (PubMed:18683158).  Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties (PubMed:19763315).  In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
What are the official names of this protein?
Tryprostatin B 6-hydroxylase, Cytochrome P450 monooxygenase ftmP450-1, Fumitremorgin biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.