PharMolix/UniProtQA huggingface dataset:
Protein: YCAD_SALCH
Sequence: MSTYTRPVMLLLCGLLLLTLAIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRIVNQQTQTRHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLLRNAGQTPNPVAHI
What are the official names of this protein?
Uncharacterized MFS-type transporter YcaD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YFCN_SHIFL
Sequence: MKKKTTLSEEDQALFRQLMAGTRKIKQDTIVHRPQRKKISEVPVKRLIQEQADASHYFSDEFQPLLNTEGPVKYVRPDVSHFEAKKLRRGDYSPELFLDLHGLTQLQAKQELGALIAACRREHVFCACVMHGHGKHILKQQTPLWLAQHPHVMAFHQAPKEYGGDAALLVLIEVEEWLPPELP
What are the official names of this protein?
UPF0115 protein YfcN.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: YL14B_YEAST
Sequence: MESQQLSQHPHISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPNSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIQQCGMEEVRGWSCVFKNSQVTICLFVDDMVLFSKNLNSNKRIIEKLKMQYDTKIINLGESDEEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
What is the function of this protein?
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane.  Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
What are the official names of this protein?
Transposon Ty1-LR4 Gag-Pol polyprotein, Gag-Pol-p199, TY1A-TY1B, Transposon Ty1 TYA-TYB polyprotein, p190.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BIOD_HALMT
Sequence: MTNITHDFAVVGTDTGVGKTVVTAGLVGWLRNAGHDAQAVKPAQTGYPPDDDAEFVATACGTDAAATCGPRLEPALAPEIAADVADERIDYTAIFETCAAALDRDGPGVIEGIGGLRVPLADGKEVVDLVSELDVPTILVARSGLGTLNHTALSVEALRRRDVFVSGIVLNQFEGETAAERTNPRVLEEMTGCPVYTMPPLSIAKPEDAVAGVCEHLPVEQVLSSVERDPIE
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring (By similarity).  This archaea does not encode bioA (which catalyzes the formation of the precursor for this reaction in the cannonical pathway), instead it encodes bioU, which replaces bioA and also performs the first half of the cannonical BioD reaction.  Thus in this archaea BioD has a different substrate (By similarity).
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_RICCK
Sequence: MSKVKKNEETLSEVLVDVNRITKVVKGGRRFAFSACMVVGDKAGRVGAGHGKAKEVNEARGKAKQAAKKRMMKVPLYQNRTIHHDVIGKSGAAKVILRRAKAGTGVIAGGSMRAIFHSLGVHDIVAKSIGSTNVYAMISATFDALNKLASPKSIAMRRDKRVNEISVKSYDV
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: LEPA_BURMA
Sequence: MDHIRNFSIIAHIDHGKSTLADRIIQLCGGLSDREMESQVLDSMDLERERGITIKAQTAALTYRARDGKVYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIELGVEVVPVLNKIDLPAANPENAIAEIEDVIGIDAMDAVRCSAKTGLGVEDVLESLIAKVPPPKGDPDAPLQALIIDSWFDNYVGVVMLVRIVNGTLRPKERIKLMATDAQYAVEHVGVFTPKSRNLESLSAGQVGFIISGIKELTAAKVGDTVTHATKPAPEPLPGFKEVKPQVFAGLYPVEANQYDALRESLEKLKLNDASLQYEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDMDLITTAPTVVYEVVQSDGTTIMVENPAKMPEPARIAEIREPIVTVNLYMPQDYVGSVITLCEQKRGTQINMQYHGRQVQLTYEIPMAEIVLDFFDRLKSVSRGYASMDYEFKEYRTSDVVKVDMLINGDKVDALSIIVHRSQSQYRGREVAAKMREIIPRQMYDVAIQAAIGAHIIARENIKALRKNVLAKCYGGDITRKKKLLEKQKEGKKRMKQVGSVEIPQEAFLAILRVEDK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MET2_YEAST
Sequence: MSHTLKSKTLQELDIEEIKETNPLLKLVQGQRIVQVPELVLESGVVINNFPIAYKTWGTLNEAGDNVLVICHALTGSADVADWWGPLLGNDLAFDPSRFFIICLNSMGSPYGSFSPLTINEETGVRYGPEFPLCTVRDDVRAHRIVLDSLGVKSIACVIGGSMGGMLSLEWAAMYGKEYVKNMVALATSARHSAWCISWSEAQRQSIYSDPNYLDGYYPVEEQPVAGLSAARMSALLTYRTRNSFENKFSRRSPSIAQQQKAQREETRKPSTVSEHSLQIHNDGYKTKASTAIAGISGQKGQSVVSTASSSDSLNSSTSMTSVSSVTGEVKDIKPAQTYFSAQSYLRYQGTKFINRFDANCYIAITRKLDTHDLARDRVDDITEVLSTIQQPSLIIGIQSDGLFTYSEQEFLAEHIPKSQLEKIESPEGHDAFLLEFKLINKLIVQFLKTNCKAITDAAPRAWGGDVGNDETKTSVFGEAEEVTNW
What are the official names of this protein?
Homoserine O-acetyltransferase, Homoserine O-trans-acetylase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2230_BURMA
Sequence: MQYEIVSAGEDVDDERARGRRAAAPAAPSSAVPSSAALSSAALSSAAQPTGAPPATAAARRGRDLPRERLLARGPAALSDAELVALLLGSGLPGHDVFALAHTLLARFGSLRALLDAAPDDFKGLRGIGPARTAILVAVVELARRALAEKARERPLVDSPGAVDDYLRLLIGTRPREVFVCLFLDARHRLVQTEETAHGSLTRMAVYPREIVRRALALNAAALIVAHNHPSGAVRPSAADRRLTRVLRDALALVDIKLIDHFVVGASDTFSFAQAGWI
What are the official names of this protein?
UPF0758 protein BMA2230.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: GLYA_FRATH
Sequence: MFSFEKNSLKNTDKEIFDAIELEVKRQHEHVELIASENYASPAVMEAQGSQLTNKYAEGYHGKRYYGGCEFVDIAEKLAIERAQQLFGVDYANVQPHSGSQANAAVYNAVLKPGDTVLGMDLGAGGHLTHGSKVNFSGKIYNSIQYGLDENGDIDYEQVAQLAKEHKPKMIIAGFSAFSGIINWQKFREIADSVDAVLMADIAHVAGLVAAGVYPNPFPYVYVATTTTHKTLRGPRGGLILCNNNPELAKKFQSAIFPGIQGGPLMHVIAAKAVAFKEALEPSFVDYQKQVLKNAKAMEKVLKQRGINIISGGTSNHLLLLDITNTGFSGKEAEAALGRANITVNKNSIPNDPRSPFVTSGLRIGSPAITTRGFKEKECELVANLLADVVFNCGDEKVENETAAKVLDLCDKLPVYK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_NITOC
Sequence: MKDKLIVFDTTLRDGEQSPGASMTREEKVRIAKALERMRVDVIEAGFPVASQGDFEAVQAVARSVRESTVCGLARALGADIDRAGEALAEAESARIHTFIATSPIHMKRKLRMEPDQVLEHAVKAVKRAREYTDDVEFSPEDAGRSEIEFLCRILEAVIAAGARTVNIPDTVGYNLPEQFAQLIRTLRERVSNSDKAIFSVHCHNDLGMAVANSLAAVMSGARQVECTINGLGERAGNAALEEVVMAVRTRQDSFPCDTNVDISQIVPTSRLVSGITGFSVQPNKAIVGANAFAHASGIHQDGVLKERQTYEIMSAEDVGWHANQMILGKHSGRNAFRARLRELGIELETEEELNAAFQRFKELADKKHVIYDEDLQALVTDANLAAENERFKLSWLKVVSETGETAIASVTLSVDSIERQASAPGSGPVDAAYKAIDSILQSNTELLLYSVNSITSGTDAQGEVTVRLKKNGRIANGQGADTDIVMASAKAYVNALNKILYPVERAYPQV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: TPS14_TRIWF
Sequence: MFMSSSSSSHARRPQLSSFSYLHPPLPFPGLSFFNTRDKRVNFDSTRIICIAKSKPARTTPEYSDVLQTGLPLIVEDDIQEQEEPLEVSLENQIRQGVDIVKSMLGSMEDGETSISAYDTAWVALVENIHHPGSPQFPSSLQWIANNQLPDGSWGDPDVFLAHDRLINTLACVIALKKWNIHPHKCKRGLSFVKENISKLEKENEEHMLIGFEIAFPSLLEMAKKLGIEIPDDSPALQDIYTKRDLKLTRIPKDIMHNVPTTLLYSLEGLPSLDWEKLVKLQCTDGSFLFSPSSTACALMHTKDGNCFSYINNLVHKFNGGVPTVYPVDLFEHIWCVDRLQRLGISRFFHPEIKECLGYVHRYWTKDGICWARNSRVQDIDDTAMGFRLLRLHGYEVSPDVFKQFRKGDEFVCFMGQSNQAITGIYNLYRASQMMFPEETILEEAKKFSVNFLREKRAASELLDKWIITKDLPNEVGFALDVPWYACLPRVETRLYIEQYGGQDDVWIGKTLYRMPYVNNNVYLELAKLDYNNCQSLHRIEWDNIQKWYEGYNLGGFGVNKRSLLRTYFLATSNIFEPERSVERLTWAKTAILVQAIASYFENSREERIEFANEFQKFPNTRGYINGRRLDVKQATKGLIEMVFATLNQFSLDALVVHGEDITHHLYQSWEKWVLTWQEGGDRREGEAELLVQTINLMAGHTHSQEEELYERLFKLTNTVCHQLGHYHHLNKDKQPQQVEDNGGYNNSNPESISKLQIESDMRELVQLVLNSSDGMDSNIKQTFLAVTKSFYYTAFTHPGTVNYHIAKVLFERVV
What is the function of this protein?
Diterpene synthase that catalyzes the formation of (-)-kolavenyl diphosphate from geranylgeranyl diphosphate (GGPP).
What are the official names of this protein?
(-)-kolavenyl diphosphate synthase TPS14, chloroplastic, Terpene synthase 14, TwTPS14.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsc subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CDHR2_MOUSE
Sequence: MAWLWLLCALLPAFMVSVTANSPPSFGVNMTLVTLPEDLPVGAVAFWLVATDSDNDHLTYGISGPNASYFSVNANTGEVKLASPLDFETVPFFKITISTSDGLNIRTAEMQVIVEDRNDNIPVFLNTEFSTSINETLPVGSVVFSVLAEDKDTGTAGLVQYFIEKVIPSTANSNNLFRILENGSIVLNDTLSYNNKSAFYQLELKACDSGGILDNKPKTQCSQPVFVSISVIDEPDLDPRFIREFYSASVAEDATLGTSVLTVEAVDSDKGINDIVTYSVSNSTRPGWFDIREDGVIFVNGSLDREQLLLENEEVQIQVTATEKNLNIYGQEAKASMWVTIRVTDVNDHKPEFYNCSLPGCSFSPQEAQVNFIGYVDEHASARISIDGLTMVAYDPDQGDNGTFLLSLNGQDAEAFNVSPERAAGSVSVQVVVRNSEMVDYEKETVMVVEVVATDSVSNNYSVATVTIHLRNINDHRPVFSQSLYELTVPEHCPTGYLVTDKIQATDLDGDEWGPITYSLLPGNGADLFEVEPNSGNLTVKNGTLLDREKQAVYYLTLQATDGGNQSTTTALEITLLDINDNPPVVRGSYNVFVPEENGNVSVTIQAYDDDQPDTNNSLLVFSLLPGPYSSNFSLDPNTGLLRNLGPLDREAIDPALEGRIVLTVIVADCGEPSLSTNVNVTITVEDINDNLPVFNQSYEFSVWERVPGAWVGTVKAWDADQTAANNRISFSLSGTGANNFILQGNVLEQGWAEGSLWLLPDVRLDYETQKFFHLTVSAENPGPQGLDSTANVTVTVMDVNDEPPTLDAASLQAISVTENGSEHGQVTRVIAQDVDTAALLRIELVDVICTKAGVDVGSVCHGWFSVDGNGSVYINQSEAIDYEACHLVTLVVRAYDLNTDPGFDAYSSNGSLLINIKDKNDNAPYFLPNNQTFVIIPELVLPNQQVASVQARDEDSEDNGIIMFSILKAEFVRKDGTSNPVQVFRITRSVEAGLFTGSIELVTNLDSTIQGTYQVTVQAQDQPTLGPALETQTTLNLFTVDQSYRVRLQFSTSKEDVGANMEEIKEALIQATRTSVYVVTIQNIDSTARARASSYMDAYFVFSNGTALTLTELNMMIRKDQDALRQLLQLGLVVVSSQESQEPDQQKLLTSVIIGLVVSLVLVLVILITALVCLRKSYHRKLRAMKAGKEARKTPIETTAPTAAIPGTNMYNTDRANPVLDLPTKDLGLECHSSSDLDYDSLNSLDENSVDLDMDSKEFKRKDLPGDPPEPDPEPLTAVLSGRSAGASEQQKKNLSFTNPGLDTTDL
What is the function of this protein?
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli.  Thereby, controls the packing of microvilli at the apical membrane of epithelial cells.  Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC.  This complex plays a central role in microvilli and epithelial brush border differentiation.  May also play a role in cell-cell adhesion and contact inhibition in epithelial cells.
What are the official names of this protein?
Cadherin-related family member 2.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell junction.
Protein: TCTD_SALTS
Sequence: MRLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLHSEMYALAVLDINMPGMDGLEVVQRLRKRGQTLPVLLLTARSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVHEVQQLGELIFHDEGYFLLQGQPLALTPREQALLTVLMYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQGSDVRITTLRGLGYVLERGDEVG
What is the function of this protein?
Transcriptional activator of the tctI tricarboxylate transport system operon.
What are the official names of this protein?
Transcriptional regulatory protein TctD.
Protein: RK20_PANGI
Sequence: MTRIRRGYIARRRRTKIRLFASSFRGAHSRLTRTITQQKIRALVSSHRDRDRQKRNFRRLWITRINAVIREGGVSYSYSRLIHDLYKKQLLLNRKILAQIAISNKNCLYMISNEIIKEVDWKESTGII
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ESF2_NEUCR
Sequence: MPEDDVRNKFLDAGDSDDDAGHGSDSEDDFQKGGRNAKRRRVSDDEDSEADDFTDAEEEHDQDDAESKDAPAKDGQETTDGKEKKDGKKEKEKKSVLASDLPGMTKPLTKKNLIVTEEAIKKSGVVYISRVPPFMTPAKLRSLLEPYGKLNRIFLAPEDPVARRKRIRSGGNKKKMFTEGWIEFVKKKDAKKACELLNARPIGGKKGSYYRDDIWNLLYLKGFKWHNLTEQIAAENAERSSRMRAEISKTTKENKEFVRNVERAKVLQGIQAKKASKGSKAGGEGAAQVTESTIPSAAATTTTTTNDDKRRTFKQIPLAKKRKLDETQPEQVQRVLSKIF
What is the function of this protein?
Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis.  Required for the early cleavages at sites A0, A1 and A2 (By similarity).
What are the official names of this protein?
Pre-rRNA-processing protein esf-2, 18S rRNA factor 2.
What is the protein family that this protein belongs to?
Belongs to the ESF2/ABP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: KHSE_ALISL
Sequence: MSVVVYAPASIGNVSVGFDVLGAAVSPIDGSLLGDRVLVESGSDAFTLATSGRFVDKLPENPQDNIVYDCWKVFARELETKNVTLKPIHMVLEKNMPIGSGLGSSACSIVAALDALNQFHDKPLTEMELLALMGEMEGQISGGIHYDNVAPCYLGGLQLMVEELGIISQEVPCFDEWYWVMAYPGIKVSTAEAREILPSQYRRQDVIAHGRNLAGFIHACYSKQPELAAKMIKDVVAEPYRERLLPNFAQARAYAASAGALTTGISGSGPTLFSICKDKDIAERVSRWLQDNYVQNDEGFVHVCRLDKQGSQVTGSKL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIP_MESAU
Sequence: MKFPMVAAALLLLCAVRAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTSEKDEL
What is the function of this protein?
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity).  Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity).  Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR).  In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1.  Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity).  Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER).  May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel.  Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating.  May also play a role in apoptosis and cell proliferation (By similarity).
What are the official names of this protein?
Endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, GRP-78, Binding-immunoglobulin protein, BiP, Heat shock protein 70 family protein 5, HSP70 family protein 5, Heat shock protein family A member 5, Immunoglobulin heavy chain-binding protein.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Melanosome. Cytoplasm. Cell surface. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Localizes to the cell surface in epithelial cells; high levels of free iron promotes cell surface localization (By similarity).
Protein: EFG_CORGB
Sequence: MAQEVLKDLNKVRNIGIMAHIDAGKTTTTERILFYTGINRKVGETHDGGATTDWMEQEKERGITITSAAVTCFWDNNQVNIIDTPGHVDFTVEVERSLRVLDGAVAVFDGKEGVEPQSEQVWRQATKYDVPRICFVNKMDKLGADFYFTVGTIEDRLGAKPLVMQLPIGAEDNFDGVIDLLEMKALTWRGVTPIGTEATVEEIPAELADRAAEYREKLLETVAESDEELMEKYFGGEELSIAEIKAAIRKMVVNSEIYPVYCGTAYKNKGVQPLLDAVVDFLPSPLDLGETKGTDVKDPEKVLTRKPSDEEPLSALAFKIAAHPFFGKLTFVRLYSGKVEPGEQVLNSTKNKKERIGKLFQMHANKENPVEVAHAGNIYAFIGLKDTTTGDTLCDANAPIILESMDFPDPVIKVAIEPKTKSDQEKLGVAIQKLAEEDPTFTVELDDESGQTVIGGMGELHLDVLVDRMKREFKVEANIGDPQVAYRETIRKPVESLSYTHKKQTGGSGQFAKVIITIEPYAPAPEELEEGESAIYKFENAVTGGRVPREYIPSVDAGIQDAMQYGFLAGYPLVNVKATLEDGAYHDVDSSEMAFKLAGSQAFKEAVAKAKPVLLEPIMSVEITTPEEYMGEVIGDVNARRGQIASMDDRAGAKIVKAKVPLSQMFGYVGDLRSKTQGRANYSMIFDSYAEVPANVAADVIAERNGTAS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_AROAE
Sequence: MKSLLADLFKQTLPNEDQFDAITIGLASPDKIRSWSYGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTLSKVRRERMAHIELASPTAHIWFLKSLPSRLGMVLDMTLRDIERVLYFEAFVVVEPGMTPLNRGQLLTEDDYLAKVEEYGDDFDALMGAEGIRGLLRTLDVKLEIEKLRGDLETTGSEAKIKKFSKRLKVLEAFMQSGIKPEWMILEVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELKAPEIIVRNEKRMLQESVDSLLDNGRRGKAMTGANKRPLKSLADMIKGKGGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFIFNKLELMGLATTIKQAKKMVESQEPVVWDILEEVIREHPVMLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCVAFNADFDGDQMAVHVPLSLEAQMEARTLMLASNNVLSPANGEPIIVPSQDIVLGLYYATREGVNVAGEGMAFSDVGELKRAYESKQLSLHARVSVRLKEVEVSAEGERRDKITRYNTTAGRAMLSEILPPGLPFSVLDKALKKKEISRLINASFRRCGLKETVVFADKLMQFGFRLATRAGISIAVKDMLVPRQKDVLIHAAEQEVKEIARQYTSGLVTDGERYNKVVDIWGRAGDQVAKAMMDQLGQEDVVNRHGDTVKQESFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITTNFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVTQDLVVTEDDCGTRDGFVMKALIEGGEVIEPLRDRILGRVCAEDVVNPESQETVIEAGSLLGEDAVDLIESLGIDEVKVRTALTCETRYGLCGKCYGRDLGRGSQVNVGEAVGVIAAQSIGEPGTQLTMRTFHVGGAASRAAAASGVESKSAGTVRFAGNMRYVSNAKGEKIIIARSAEVVVADDMGRERERHKLPYGATLLVDDGAPVKAGVLLATWDPHTRPIVTEYSGTVKFENVEEGATVAKQIDEVTGLSTLVVIDGKRRTSGASSKGVRPQVKLLDERGEEVKIAGTDHSVAITFQVGSLITVKDGQEVSVGDILARIPQESAKTRDITGGLPRVAELFEARPPKDAGVLAEYTGTVSFGKDTKGKQRLVITEADGTAHEFLIPKDKHVMVHDGQVVNKGELIVDGPADPHDILRLQGIEALARYIIDEVQDVYRLQGVKINDKHIEVIVRQMLRRVVINDAGNSRFIREEQVERSEVLDENDRIEAEGKLPAQYQNVLLGITKASLSTDSFISAASFQETTRVLTEAAIMGKRDDLRGLKENVIVGRLIPAGTGMAYHRNRKAQNAGEDLGPEHAWAEMQEVVPEVPADVSQDVQAG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.