PharMolix/UniProtQA huggingface dataset:
Protein: SV2B_HUMAN
Sequence: MDDYKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVLM
What is the function of this protein?
(Microbial infection) Receptor for the C. botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119).  Probably also serves as a receptor for the closely related C. botulinum neurotoxin type A1.
What are the official names of this protein?
Synaptic vesicle glycoprotein 2B.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin- secreting cells of the pancreas (By similarity). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity).
Protein: RER1_PONAB
Sequence: MSEGDSVGESVHGKPSVVYRFFTRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFKFWHAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHGKRRYRGKEDAGKAFAS
What is the function of this protein?
Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
What are the official names of this protein?
Protein RER1.
What is the protein family that this protein belongs to?
Belongs to the RER1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: RBY1D_HUMAN
Sequence: MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY
What is the function of this protein?
RNA-binding protein which may be involved in spermatogenesis.  Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
What are the official names of this protein?
RNA-binding motif protein, Y chromosome, family 1 member D.
What are the subcellular locations of this protein?
Nucleus.
Protein: TOIP1_RAT
Sequence: MAGERWRAEGLGEGWAIYVTPRAPIREGRRRLATQNGDGSDAPAYETHPSRHGRREVRFSEEPPEVYGDFEPRAAKERSPGERRTPPEKFRSDSAKEEVRESAYNLRSRQRRQRGPQEAEEMKTRRSTRLEQHSQQAQQQLSPATSGRGLRDAQSLSEDRGEDEPSSQPVTSQTVSKKTVRTPETSVMSEDPISNLCRPPLRSPRPDASIVQHINPFEEGETEDDLESSYSDVTIRIRSRDSVESRDEAAVAAGHHPDSLWGLPHSRGDFTAHENQPSLLPTGCQKNPQEWVEQAVRMRTRMAYNNIQKSDFGNQSPSTSRQQAAVQPPDESSVKIKWWLLILVAALAMGIYWFFHTPVVETTAVQEFQNQMKQLQSKYQSQDEKLWKRGTTFLEKHLNSSLPRPQPAILLLTAAQDAAEVLKCLSEQIADAYSSFRSVRAIRIDGAGKAAQDSDLVKHEVDQELTDGFRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEQTLEASLGLKEIEEKVRDFLKVKFTSSDTANSYNHMDPDKLNGLWSRISHLVLPVQPENALKAGSCL
What is the function of this protein?
Required for nuclear membrane integrity.  Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane.  Binds to A- and B-type lamins.  Possible role in membrane attachment and assembly of the nuclear lamina.
What are the official names of this protein?
Torsin-1A-interacting protein 1, Lamina-associated polypeptide 1B, LAP1B, Lamina-associated polypeptide 1C, LAP1C.
What is the protein family that this protein belongs to?
Belongs to the TOR1AIP family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Single-pass membrane protein.
Protein: RPOA_SALTY
Sequence: MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RHDF1_HUMAN
Sequence: MSEARRDSTSSLQRKKPPWLKLDIPSAVPLTAEEPSFLQPLRRQAFLRSVSMPAETAHISSPHHELRRPVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQRRSFTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQADLTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH
What is the function of this protein?
Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation.  Does not exhibit any protease activity on its own.
What are the official names of this protein?
Inactive rhomboid protein 1, iRhom1, Epidermal growth factor receptor-related protein, Rhomboid 5 homolog 1, Rhomboid family member 1, p100hRho.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly localized in the endoplasmic reticulum membrane (PubMed:15965977).
Protein: URED_YERPN
Sequence: MTAQSQNIVETPSRVRAHALGVNAPELAKYQDEPAQMRSGAVGKSGYLKLRFAKREHCSILAEMERRVPSLVQKALYWDEEIPELPCVTMISTSGCILQGDRLATDVHVEAGACAHVTTQSATKVHMMNANYASQIQNFIVEEGGYLEFMPDPLIPHRNSRFITDTTISIHPTATAIYSEVLMSGRKYHHADERFGFDVYSSRVAAQNLAGKELFVEKYVLEPKVESLDAVGVMQTFDAFGNVILLTPKEHHDRILARVPAHFDIKGGDCQRRDAST
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1459_BURCM
Sequence: MDIAHDLQSIGAQEQALVFPHFDPARAWALGNRMHALATARGHAIAIDIVTFGQPLFYAALAGATPDNADWVRRKRNVVAHFRRSSYAIGLRMQQAGASLADKHGLPISDYSPHGGSFPLTVAGAGVIGSITASGLPQRADHEFVVEALCAELGQDYAALALARS
What are the official names of this protein?
UPF0303 protein Bamb_1459.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: RF1_SALTI
Sequence: MKPSIVAKLEALHERHEEVQALLGDAGIIADQDRFRALSREYAQLSDVSRCFTDWQQVQDDIETAQMMLDDPEMREMAQEELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSMSEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPEAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAETAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDETMEGKLDMLIEPIVQEHQADLLAALSEQE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPPR_PLESU
Sequence: MEAIGVLMMCPMSTYLEQELDKRFKLFRYWTQPAQRDFLALQAESIRAVVGNSNAGADAELIDALPKLEIVSSFSVGLDKVDLIKCEEKGVRVTNTPDVLTDDVADLAIGLILAVLRRICECDKYVRRGAWKFGDFKLTTKFSGKRVGIIGLGRIGLAVAERAEAFDCPISYFSRSKKPNTNYTYYGSVVELASNSDILVVACPLTPETTHIINREVIDALGPKGVLINIGRGPHVDEPELVSALVEGRLGGAGLDVFEREPEVPEKLFGLENVVLLPHVGSGTVETRKVMADLVVGNLEAHFSGKPLLTPVV
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate and 3,4-dihydroxyphenylpyruvate to 3,4-dihydroxyphenyllactate in the biosynthesis of rosmarinic acid.  Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid.  NADP is the preferred substrate.
What are the official names of this protein?
Hydroxyphenylpyruvate reductase, HPPR.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: CFLAR_PONAB
Sequence: MSAEVIHQVEEALDTDEKEMLLFSCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSFKDPSNNFRLHNGRSKEQRLKEQLGTQQEPVKKSIQESEAFLPQSVPEERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKIFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADVSLLEWSHSSPSLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLIPSYT
What is the function of this protein?
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells.  Acts as an inhibitor of TNFRSF6 mediated apoptosis.  A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex.  Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis.  Lacks enzymatic (caspase) activity (By similarity).
What are the official names of this protein?
CASP8 and FADD-like apoptosis regulator.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
Protein: SSUD_ECO7I
Sequence: MSLNMFWFLPTHGDGHYLGTEEGSRPVDHGYLQQIAQAADRLGYTGVLIPTGRSCEDAWLVEASMIPVTQRLKFLVALRPSVTSPTVAARQAATLDRLSNGRALFNLVTGSDPQELAGDGVFLDHSERYEASAEFTQVWRRLLLGETVDFNGKHIHVRGAKLLFPPIQQPYPPLYFGGSSDVAQELAAEQVDLYLTWGEPPELVKEKIEQVRAKAAAHGRKIRFGIRLHVIVRETNDEAWQAAERLISHLDDETIAKAQAAFARTDSVGQQRMAALHNGKRDNLEISPNLWAGVGLVRGGAGTALVGDGPTVAARINEYAALGIDSFVLSGYPHLEEAYRVGELLFPHLDVAIPEIPQPQPLNPQGEAVANDFIPRNVAQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: NTPPA_THEP1
Sequence: MRIILASSSPRRRQLMELLGIEFEVEKPDVEEEFLESPEETVRELSLRKAEWVFKKRKEEEILVIGSDTVVVLDGNILGKPESLEEAKGMLKKLSGEWHVVYTGVAFVSSETKDVIVSSTKVRFRELPESVIDYYVEKYRPLDKAGAYGIQDFAAVFVEKIEGDFFTVVGFPLGMVWQYLYEKGWWKFASKREDDKGGARVAFG
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_SHEDO
Sequence: MNRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKADGAYIFDADGNKYIDYVGSWGPMILGHNHPKIRQAVLDAVENGLSFGAPTELEVKMAEKVIAMVPSIEQVRMVSSGTEATMSAIRLARGYTNRDKILKFEGCYHGHADCLLVKAGSGALTLGQPSSPGIPEDFAKHTLTATYNDLASVRSLFELHPDAISCIILEPVAGNMNCIPPIPGFLQGLRGLCDEFGALLIIDEVMTGFRVAMGGAQAHYGVVPDLTTLGKVIGGGMPVGAFGGKKAIMQYIAPTGPVYQAGTLSGNPIAMSAGLAQMEALCEPGLYPALAEKTQRIALGMKAAADKHSIPLSITYVGGMFGFFFTTDSAPMTSFAQVTQCNMEHFRYFYHAMLAQGVYLAPSAYEAGFLSMAHGEDELAMTLKAVDSVFAEMKVAFKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_STRPQ
Sequence: MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGIEFDLAFTSVLTRAIKTTNLALENAGQLWVPTEKSWRLNERHYGALTGKNKAEAAEQFGDEQVHIWRRSYDVLPPAMAKDDEYSAHKDRRYADLDPALIPDAENLKVTLERAMPYWEEKIAPALLDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFELDEKLNIVKEYYLGGE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: DAPE_RICBR
Sequence: MHTTYLKNLIGFESLTPQSNGAIEYIDDLLKEHGFKTEVKIFGETEQVTNLYAVYGNSKPNICFVGHVDVVPAGDPNLWHNSNPFKAHEQEGKIYGRGTVDMKGSIACFLAASLDFIKNNTDFVGSISFLLTSDEEGKAKHGTKEMLQYIYNQGHEIDFAIVGEPTCEKEIGDTIKIGRRGSINFKLAVKGLGGHVAYPQKANNPLPCLIRILNELTNIKLDKGTEFFQNSNLEVTNIDVDNNTTNVIPETATVHFNIRFNNLHSAETLAKQVEEIIKQHCQKHKLDYTLEYNSSADSFIQNPNDKIKEFATIVEKTLNIKPKFSTSGGTSDARFVKNYCPLVEFGLLSDTAHKINEYTKISDLQKLYDVYYNFLMETLNVTGSPPLLGMT
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: AMPP2_TUBMM
Sequence: MTSDSTVDKILAGKYPAKQHAENVVERLLHVHPDLTDGVIYLESQRSKLYENSDQEVPFRQRRYFYYLSGCDLADSYLTYSIRDRKLTLFIPPIDPASVLWSGLPLSNSEALEKYDVDEVLPTSATALPTTSYSSLMFVIESQTSRTFHLQNTESLEPAIERARAIKDEYEVALIKKANRISALAHHSCLRAIKSAGNEREIEAVFTKECIANGAPKQAYSGIFGSGRSASTLHYVHNNQPLAGKLNLLLDAGAEYNNYASDITRTFPISGQFTKESREVYDIVLDMQKQCLAASKAGAVWDDIHILAHKVAIQGLLKIGVLRNGSVDEILSNRTSTAFLPHGLGHYLGMDTHDCGGNPNYADPDPMFKYLRKRGPLPAGAVITVEPGIYFCEFIIKPYLEDEKHAKYIDKDVLNRYWDVGGVRIEDNILITEGGYENLTNVAKEVDDMLKFING
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase GSTUM_00008071001, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: FRSA_ECOL6
Sequence: MTQANLSETLFKPRFKHPETSTLVRRFSHGAQPPVQSALDGKTIPHWYRMINRLMWIWRGIDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWATQAMVWQQKACAEEDPQLSGRHWLHAATLYNIAAYPHLKGDDLAEQAQALSNRAYEEAAQRLPGTMRQMEFTVPGGAPITGFLHMPKGDGPFPTVLMCGGLDAMQTDYYSLYERYFAPRGIAMLTIDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLESPRLKVVACLGPVVHTLLSDFKCQQQVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGYWKNDPFSPEEDSRLITSSSADGKLLEIPFNPVYRNFDKGLQEITDWIEKRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: EFTS_RICM5
Sequence: MSEINISAAAVKELREKTGAGMMDCKKALIETSGNFEEAIDFLRKKGLAVAAKKAGRIASEGLTAAKVDGLTGVVIEVNSETDFVARNEQFQALVKDIANLAVIAKTIDTLKTFKMQSGKSVEEEIIENIATIGENLTLRRMDILEISEGAIGSYVHNEVVPNLGKISVLVGLASNAKDKAKLEALAKQIAVHVAGNNPQSIDDSGLDQALVERERKVFFEKSKEEGKPDNIIEKMVEGRIRKFFSEVVLLQQNFLFEPKLTVAEVIKNAEKELGAAIKIAKFIRYELGEGIEHGEKNFADEVAAITQG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP1G_HUMAN
Sequence: MADLDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK
What is the function of this protein?
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets.  Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.  Dephosphorylates RPS6KB1.  Involved in regulation of ionic conductances and long-term synaptic plasticity.  May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.  Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.  In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation.  May dephosphorylate CSNK1D and CSNK1E.  Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, PP-1G, Protein phosphatase 1C catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430). Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430). Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430). Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430). Colocalizes with DYNLT4 in the microtubule organizing center (MTOC)(PubMed:23789093).
Protein: RL30_PHOLL
Sequence: MAKTIKVTQIRSSIGRLPKHKATLVGLGLRRIGHTVEREDTPAIRGMINLVSYMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: NSRR_ECODH
Sequence: MQLTSFTDYGLRALIYMASLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGYVTAVRGKNGGIRLGKPASAIRIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLTELDNYTLADLVEENQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: NNRE_DICDI
Sequence: MNAIKFLTQNEAIVMDQLLMGKKYAFSTDSLMELAGLSCASVIQHVYPTISKKVLTICGPGNNGGDGLVASRHLVQFGYDVNIYYPKRTDKELYHNLVTQCKHEGIEFLESMPTNDQLNNDYGLVIDSIFGYSFKGDIRSPFDTIIKDSLNNIKTPIASIDMPSGWDVENGNIKNLFTPDLLISLAAPKLGSKSFKGKHYLGGRFLPKEFLKETNLTIPKFNGSNQFVDITNYQN
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
Protein: GRB2_MOUSE
Sequence: MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQMPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
What is the function of this protein?
Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element.  Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
What are the official names of this protein?
Growth factor receptor-bound protein 2, Adapter protein GRB2, SH2/SH3 adapter GRB2.
What is the protein family that this protein belongs to?
Belongs to the GRB2/sem-5/DRK family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endosome. Golgi apparatus.
Protein: MPG11_CANGA
Sequence: MKGLILVGGYGTRLRPLTLTVPKPLVEFGNRPMILHQIEALANAGVTDIVLAVNCRPEVMVETLQKYEKEYGVSITFSVETEPLGTAGPLKLAEKVLKKDNSPFFVLNSDVICEYPFKELADFHKAHGGKGTIVATKVDEPSKYGVIVHDIATPNLIDRFVEKPKEFVGNRINAGLYILNPEVIDLIEMKPTSIETETFPILVEQKSLYSFDLEGFWMDVGQPKDFLSGTVLYLNSVSKKNPEKLTKGDNIVGNVMVDPSAKIAASAKVGPDVVIGPNVTIGEGVRITRSVVLSDSSIQDHSLVKSTIVGWKSTVGKWCRLEGVTVLGDNVVVKDEVYVNGGKVLPHKSISANVPSEAIIM
What is the function of this protein?
Involved in cell wall synthesis where it is required for glycosylation.  Involved in cell cycle progression through cell-size checkpoint (By similarity).
What are the official names of this protein?
Mannose-1-phosphate guanyltransferase 1, ATP-mannose-1-phosphate guanylyltransferase 1, GDP-mannose pyrophosphorylase 1.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSF2_FELCA
Sequence: MWLQNLLFLNTVVCSISAPTSSPSSVTRPWQHVDAMKEALSLLNNSSEITAVMNETVEVVSEMFDPEEPKCLQTHLKLYEQGLRGSLISLKEPLRMMANHYKQHCPLTPETPCETQTITFKNFKEKLKDFLFNNPFDCWGPDQK
What is the function of this protein?
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
What are the official names of this protein?
Granulocyte-macrophage colony-stimulating factor, GM-CSF, Colony-stimulating factor, CSF.
What is the protein family that this protein belongs to?
Belongs to the GM-CSF family.
What are the subcellular locations of this protein?
Secreted.