PharMolix/UniProtQA huggingface dataset:
Protein: METAS_SHEWM
Sequence: MPVKIPDDLPAAEILESENIFVMSETRAANQDIRPMKVLILNLMPNKIETETQLLRLLGNTPLQVDVDLLRIHDKESKHTSIDHMNNFYRDFEAVRQKNYDGLIITGAPLGQIEFEEVSYWDHIREIIDWSQQHVTSVLFLCWAAHAALFHLYGLNRNLLEQKRSGVFVHRRTTQHFPLLRGFDDEFLAPHSRFAEMSLEQLKAHPELQVLTESDTAGAYMVLSRNNRNLFVMGHPEYQKSTLKDEYHRDLEQGLNPDVPQNYFRDDNPEKEPVARWHGHGSLLVSNWLNYYVYQLTPYNLDDMSGITPWENKQ
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXS_BACHK
Sequence: MTNVTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMALERVPADIRAAGGVSRMADPTIVEEVMGAVSIPVMAKCRIGHLVEARVLESLGVDYIDESEVLTPADEVYHLNKRDYTVPFVCGCRDIGEAARRIAEGASMLRTKGEPGTGNIVEAVRHMRQVNAEIRQVASLREDELMTYAKNTGAPYEVLLEIKRLGRLPVVNFAAGGVATPADAALMMQLGADGVFVGSGIFKSENPAKFARAIVEATTHYEDYELIASLSKGLGNAMKGIEISTLLPEQRMQERGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: CHAC1_RAT
Sequence: MKQESAAQSTPPPSLSPAPSAQPSWEDGDPQALWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVRGEQVSEALKYLNVREAVLGGYDTKEVTFYPQDTPDQPLTALAYVATPQNPGYLGPAPEEVIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQDEHLEAIVDAVGSLLPCSYLSEQPLALI
What is the function of this protein?
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide.  Acts specifically on glutathione, but not on other gamma-glutamyl peptides.  Glutathione depletion is an important factor for apoptosis initiation and execution.  Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade.  Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
What are the official names of this protein?
Glutathione-specific gamma-glutamylcyclotransferase 1, Gamma-GCG 1, Blocks Notch protein, Botch, Cation transport regulator-like protein 1, Neuroprotective protein 7.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network.
Protein: Y524_LIMF3
Sequence: MSEQTPRDDGEIFTLVDEAGNEELYKEAMRFQSPETGKWYICLYPLDEENDEEVGIQAFAFEEPTSEEDELELLPIENDAEWEMVQEVLNTFIDDDGNFNA
What are the official names of this protein?
UPF0473 protein LAF_0524.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: RPOC1_ACOGR
Sequence: MIDRYKHQQLQIGSVSPQQISAWANKILPNGEIVGEVTKPYTFHYKTNKPEKDGLFCERIFGPIKSGICACGNYRVIGAEKEDPKFCEQCGVEFIDSRIRRYQMGYIKLACPVTHVWYLKRLPSYIANLLDKPLKELEGLVYCDFSFARPIAKKPTFLRLRGLFEYEIQSWKYSIPLFFTTQGFDTFRNREISTGAGAIREQLADLDLRIVIDNSSVEWKELGDEGSTGNEWEDRKIGRRKDFLVRRMELAKHFIRTNVEPERMVLCLLPVLPPELRPIIQIDGGKLMSSDINELYRRVIYRNNTLTDLLKTSRSTPGELVMCQEKLVQEAVDTLLDNGIRGQPMRDGHNKVYKSFSDVIEGKEGRFRETLLGKRVDYSGRSVIVVGPSLSLHRCGLPREIAIELFQTFVIRGLIRQHLASNIGIAKSKIREKEPIVWEILQEVMQGHPVLLNRAPTLHRLGIQAFQPVLVEGRAICLHPLVCKGFNADFDGDQMAVHVPLSLEAQAEARLLMFSHMNLLSPAIGDPISVPTQDMLIGLYVLTMGNHRGIFVNRYNPCNRRNYQNKTVDNNNYKHTKEKKPYFFSSYDALGAYQQKRINLHRPLWLRWRLDQRVIGSREVPIEVQYESLGTYQEIYGHYLIVRSVKKEILCIYIRTTVGHISFYREIEESVQGFCRAYSYGT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YJZD_BACSU
Sequence: MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVLIMVLAEIMPMNKNASQH
What are the official names of this protein?
Uncharacterized membrane protein YjzD.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: G6PI_RABIT
Sequence: MAALTRNPQFQKLQQWHREHGSELNLRHLFDTDKERFNHFSLTLNTNHGHILLDYSKNLVTEEVMHMLLDLAKSRGVEAARESMFNGEKINSTEDRAVLHVALRNRSNTPIVVDGKDVMPEVNKVLDKMKAFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWFVSNIDGTHIAKTLACLNPESSLFIIASKTFTTQETITNAETAKDWFLLSAKDPSTVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLAMLGIWYINCFGCETQAVLPYDQYLHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKSTEEARKELQAAGKSPEDLMKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGVVWDINSFDQWGVELGKQLAKKIEPELDGSSPVTSHDSSTNGLINFIKQQREAKIQ
What is the function of this protein?
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity).  Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility.  Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons.  It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Autocrine motility factor, AMF, Neuroleukin, NLK, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted.
Protein: CAS2_CAPCC
Sequence: MWVMVLYDLPTETKAMQKAANLFRKRLEDDGFSLFQFSIYLRHCPSRENAEVHKKRVKMMLPKYGKVAVMTITDKQFGDMEIFHSKVREDPPPTYQQLELF
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: NUSB_STRA3
Sequence: MTSVFKDSRRDLRERAFQTLFSLETGGEFIDAAHFAYGYDKTVSEDKVLEVPIFLLNLVNGVVDHKDELDTLISSHLKSGWSLERLTLVDKSLLRLGLYEIKYFDETPDRVALNEIIEIAKKYSDETSAKFVNGLLSQFITNEN
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PODO_HUMAN
Sequence: MERRARSSSRESRGRGGRTPHKENKRAKAERSGGGRGRQEAGPEPSGSGRAGTPGEPRAPAATVVDVDEVRGSGEEGTEVVALLESERPEEGTKSSGLGACEWLLVLISLLFIIMTFPFSIWFCVKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVDLRLQTLEIPFHEIVTKDMFIMEIDAICYYRMENASLLLSSLAHVSKAVQFLVQTTMKRLLAHRSLTEILLERKSIAQDAKVALDSVTCIWGIKVERIEIKDVRLPAGLQHSLAVEAEAQRQAKVRMIAAEAEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTEKPSTVVLPLPFDLLNCLSSPSNRTQGSLPFPSPSKPVEPLNPKKKDSPML
What is the function of this protein?
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
What are the official names of this protein?
Podocin.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum.
Protein: SYL_LACP3
Sequence: MAYDHHEIDKKWQRYWAEHNEFNTTTDPKKPNYYALDMFPYPSGQGLHVGHPEGYTATDIVARMKRMQGFNVLHPMGWDAFGLPAEQYALNTGHNPKTFTKQNIETFKRQINSLGFSYDWNREINTTDPNYYKWTQWIFEQLYKHGLAYEAEVPVNWSPDLGTVVANEEVIDGKTERGGFPVVRKPMRQWMLKITAYAEKLLTDLDDLDWPESIKQMQRNWIGKSTGAQITFRVTDSHEPFDVFTTRPDTLFGATYVVMAPEHELVQKITTPAQQAVVDAYIDEAAHKSDLDRTALDKEKTGVWTGAYATNPVNGEKLPIWISDYVLASYGTGAIMSVPAHDDRDYAFAKKFGIEIKPVIEGGNVDEAAYTGDGVHINSGFLDGLNEHDAIDRMIKWLEDKGIGSAKINYKLRDWVFSRQRYWGEPIPVIHWEDGETTLVPEDELPLTLPEEADIKPSGTGESPLANLTDWVNVVDKNGRKGKRETNTMPQWAGSSWYFLRFVDPHNKEALADYDKLKAWMPVDLYIGGAEHAVLHLLYARFWNLFLYDIGAIPNKEPFQRLFNQGMILGDNHEKMSKSKGNVVNPDDVVDEYGADTLRLYEMFMGPLDAGIAWSTKGLAGARKFLDRVWSAFIDDEGKLRDRITTINDGRLDKVYNETVKKVTEDYDALHFNTAISQMMVFINSARKDDDLPLEYVEGFVKMLAPIAPHLMEEIWSRLGHDHSLTYAPWPSYDESKIKTDTYDMMIQVNGKLRGSITADVNESDDEIKQAALANDNVQKFTAGKDIKKIIVVPRKIVNIVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_PELUB
Sequence: MDFKDKKDDGILEKLVHINRITKVVKGGRRFGFSALVVVGNQAGKIGVAHAKAKQVPDAIKKANETARRVLIHVPLREGRTIHHDVYGKDGAGKIILRSAPKGTGIIAGGPVRAVCEVLGIKDIVAKSMGTSNPHNMIRATMKALSKQNSPKHIATIRNKKISDVIEKRG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: METK_PARDP
Sequence: MARQDYVFTSESVSEGHPDKLCDQISDAVLDALLAEDPAARVACEAFATTGTVVIGGEIGLSDKKKLGEYMGRIAEIARNTIRDIGYEQEKFHWNTCHVHNYLHEQSAHISQGVDRDGAGDQGIMFGYAVDETPELMPAPIQYAHAILRRLAEARKSGAEPTLGPDAKSQLSLRYENGKPVEITSLVLSHQHKDESQTSDDIRAIVEPYIREVLPAEWLTERTEWWVNPTGTFVIGGPDGDAGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYAARYLAKNVVAAGLAKRCVIQLSYAIGVAKPLSIYADTFGTSEVPEAEIERAVSRAMDLTPRGIREHLALCRPIYRRTAAYGHFGRAPDADGGFSWERTDLVEAIKREL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRD2_RAT
Sequence: MLQNVTPHKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLAPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSITSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVSAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTALPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRIGIDEDDKGPRAPRPLQPKKSKKAGGGGSNATTLSHPGFGTSAGSSNKLPKKAQKTAPPVLPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIRKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKASEKTESSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
What is the function of this protein?
Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling.  Regulates transcription of the CCND1 gene.  Plays a role in nucleosome assembly (By similarity).  May play a role in spermatogenesis or folliculogenesis (By similarity).
What are the official names of this protein?
Bromodomain-containing protein 2, Protein RING3.
What are the subcellular locations of this protein?
Nucleus. Note=Detected on chromatin and nucleosomes.
Protein: SCAM5_PONAB
Sequence: MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHLSMTKRLYYLWMLNSVTLAVNLVGCLAWLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISIIQAVGIPGWGVCGWIATISFFGTSIGSAVVMLIPTVMFTVMAVFSFIALSMVHKFYRGSGGSLSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYSNEM
What is the function of this protein?
Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5.  Probably acts in cooperation with the SNARE machinery (By similarity).
What are the official names of this protein?
Secretory carrier-associated membrane protein 5, Secretory carrier membrane protein 5.
What is the protein family that this protein belongs to?
Belongs to the SCAMP family. SCAMP5 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi- pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity).
Protein: IKBZ_MOUSE
Sequence: MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPSAPGAGDTGYLSAVPSAPGSPGSDSSDFSSTSSVSSCGAVESRPRGGARAERPQVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSNKQKASGQPVDEFKTQSVNIEQLTDLKSAVSAVGKRKGPDPLSDGPVCKRPALLPSHFVTSPQTPTPGESMEDVRHSESKLDSSAALLQNIINIKNECNPVSLNTVQVSWMSPTVPQNSPRDQCQDFHGGQAFSPPQKYQPFQVSGSPQMMDQASMYQYSPQTQNMQQPPPLPPQQQHQQNYPHNSPLQFSPYSRMSQSPKYDSNLFDTHEPQFCTGQSFVSLLTGPGEPESLAVPVPAPTSIPPQTETQLQTFSLMPSNACEAVVGVHDVGSHSLGTSLSLQNIMGSPMNTTQLGKSFFQWQVEQEESKLANIPQDQFLARDGDGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVRSNQFVDLEATNYDGLTPLHCAVVAHNAVVHELQRNRQSHSPEVQDLLLRNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY
What is the function of this protein?
Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895).  Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895).  Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895).  Seems also to activate NF-kappa-B-mediated transcription (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895).  In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (By similarity).  Promotes transcription of LCN2 and DEFB4 (By similarity).  Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (PubMed:11086164, PubMed:25107474).  Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (PubMed:11086164, PubMed:25107474).  Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (PubMed:25282160).
What are the official names of this protein?
NF-kappa-B inhibitor zeta, I-kappa-B-zeta, IkB-zeta, IkappaBzeta, IL-1 inducible nuclear ankyrin-repeat protein, INAP, Molecule possessing ankyrin repeats induced by lipopolysaccharide, MAIL.
What are the subcellular locations of this protein?
Nucleus.
Protein: BIMA_EMENI
Sequence: MTPSTSHISSQLRQLIYYHLDNNLARNALFLAGRLHAYEPRTSEASYLLALCYLQNGQVKAAWETSKHFGSRGAHLGCSYVYAQACLDLGKYTDGINALERSKGQWTSRNHWNKHSETRRQHLPDAAAVLCLQGKLWQAHKEHNKAVECYAAALKLNPFMWDAFLNLCETGVDLRVSNIYKMSPELYSMVSSAALEDVESQVLPPDGPLQTQVNPNPSLDPFTAGTTRSDSTSTHGSSALWEKLNGSTVSVASSGTGPHLPREGMETPGGQSSESDDPRVTNGNGTDVFEPPLAPAKKNRTIQTIGGDHPMDPPPKMRPTGIRPRTRTKFESDEGHTERDAGMGHRLGDRKRTVSGQVAHPSVPHSTDQGVGQRRSVRLFNQIKPSTNKISSTALGVKEGREVKKVRTTGNKARTTTSSNVGRVVSGNNRRHAGEIHDGDSKEYRGTSSTSNGSQNASSKLAISERTKSVEALAWILDLFFKIASGYFCLSRYKCSDAIQIFSSLSQGQRETPWVLAQIGRAYYEQAMYTEAEKYFVRVKAMAPSRLEDMEIYSTVLWHLKNDVELAYLAHELMDVDRLSPEAWCAVGNSFSHQRDHDQALKCFKRATQLDPHFAYGFTLQGHEYVANEEYDKALDAYRSGINADSRHYNAWYGLGTVYDKMGKLDFAEQHFRNAAKINPSNAVLICCIGLVLEKMNNPKSALIQYNRACTLAPHSVLARFRKARALMKLQDLKSALTELKVLKDMAPDEANVHYLLGKLYKMLRDKGNAIKHFTTALNLDPKAAQYIKDAMEALDDDEEDEEDMA
What is the function of this protein?
Required for the completion of mitosis in Aspergillus nidulans.
What are the official names of this protein?
Protein bimA.
What is the protein family that this protein belongs to?
Belongs to the APC3/CDC27 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ALEX_MOUSE
Sequence: MSPSPTRLAVRSVDPQKTPNLTSKAPARPSRKSEWVETTAHLRRKPCHSRHNSPAWEISGPPWSSQDHLGPHQASKPSTQRFWSPGPPLARAQAWEPIPPHQKKLCHLSSTSLPRETIASLPCKSQTLRQEVRKHWSPELFPRSPGTSDLKTLASEKTTALPLKNLCHFRSVEKNSGAIAHPQDSRESSHKSALAASSRQSRSRVRSASLPPRTRLPSGSEAPLTDHSARLSDLLLTSHATAPRWRSPDPCLRLAEPPLGSTTTPLSIWTAPQSQVMARPSKSREPQIRASAQRDPQLSEKQPRWKEALPPPLRWKEKSPLRREGTDLPPSLKQWMPSQPLLPKPSLPDLMLELLRIPRCSQIARAMPEKTGQPQERLQISSRILKNSKKPQLSAPILTEGQPQSPQPLLPSPSLKAAEIQPPSQPPRQSLPPRPSLPPGQPLSPRWSPQPRQSLPPWRSLPPGQPLSPPRSPLPGQSPLLEPIRPLEQSLAPQQCQPLLGQLPLGQPMQVHWSGEPGHSQLLPPLGHPFLPAQQLPPGQPLLPAQSLLAGQPLPPPAGPILDPPAPRSRLLTRLLRGLLRGRLPGLTSTSGAEAAAGTRHRLASARSSPPVMSRKKGPPAASSGFCGETAALACPGATRSGATQSATSSPEPSEAASVYPSVPDHDPSAPGRPRILWRRGANRCAKKPLRCESRSAQIRNAASSSTSNWRRRRWTTCVHTACCF
What is the function of this protein?
May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame.
What are the official names of this protein?
Protein ALEX, Alternative gene product encoded by XL-exon.
What is the protein family that this protein belongs to?
Belongs to the ALEX family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cell projection, ruffle. Note=Predominantly associated with cell membrane ruffles.
Protein: CH60_SULNB
Sequence: MAKEIFFSDKARNGLFEGVTKLADAVKVTMGPRGRNVLIQKSFGAPHITKDGVSVAREIELEDTLENMGAQLVKEVASNTADEAGDGTTTATVLAHSIFKEGLRNITAGANPIEVKRGMDKASAAIIEELKKISKEVKDKKEIAQVATISANSDETIGNLIAEAMDRVGKDGVITVEEAKGINDDLEVVEGMQFDRGYLSPYFVTNTEKMTCEMENPLILITDSKITSLKDLIPVLEQIQQSGRPLLIISDDLEGEALATLVLNRLKGVLNIAAVKAPGFGDRKKEMLKDIAILTGANVITEELGLSLDKATLDDLGQAGRVVIDKDNTVIVDGKGDSAAVDARVAEIKIQVENTTSEYDKEKLQERLAKLSGGVAVIKVGAATETEMKEKKDRVDDALSATKAAVDEGIVIGGGAALAKASKAVKLDLEHDEAVGAEIILRAVYAPMKQIAQNAGFDAGVVADKIANNSEANLGFNAATGEYVNMLEAGIIDPLKVARVALQNATSVASLLLTTEATVSDIKEAPTPAPTMPDMGGMPGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIX5_MOUSE
Sequence: MATSPAEPSAGPAARGEAAAATEEQEEEARQLLQTLQAAEGEAAAAGAGDAAAAADSGSPSGPGSPRETVTEVPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCKSESDGNPTTEDESSRSPEDLERGVASMAAEAPAQSSIFLAGATSPATCPASSSILVNGSFLAASSPPAVLLNGSPVIINSLALGENSSLGPLLLTGGSAPQPQPSLQGVSEAKNSLVLDPQTGEVRLDEAQSEAPETKGVHGTTGEEIPGALPQVVPGPPPASTFPLTPGAVPAVAAPQVVPLSPSSGYPTGLSPTSPRLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPTNVHLINSSVGVTALQLPSSTAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPSLALPLKQEPAITVPEGALPVGPSPTLPEGHTLGPISTQPLPPASVVTSGTSLPFSPDSSGLLSSFSAPLPEGLMLSPAAVPVWPAGLELSTGVEGLGTQATHTVLRLPDPDPQGLLLGATTGTEVDEGLEAEAKVLTQLQSVPVEEPLEL
What is the function of this protein?
Transcription factor that is thought to be involved in regulation of organogenesis.  May be involved in determination and maintenance of retina formation.  Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1.  Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity).  Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3.
What are the official names of this protein?
Homeobox protein SIX5, DM locus-associated homeodomain protein homolog, Sine oculis homeobox homolog 5.
What is the protein family that this protein belongs to?
Belongs to the SIX/Sine oculis homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CHEZ_BORPE
Sequence: MNATDTGMQADPTDLIQRIASLTRMLRDSMRELGLDQAIKDAAEAIPDARDRLRYVAQMTEQAANRVLNATEAAGPIQDGMARGAQALDERWQQWYDQPLELPQARALVQDTRAFLAAVPQHTQQTQAKLMEIVMAQDFQDLTGQVIMRMMDVVGAIERELLQVLLDNVPQERRDEANSLLNGPQVNPGGKADVVTSQDQVDDLLASLGF
What is the function of this protein?
Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).
What are the official names of this protein?
Protein phosphatase CheZ, Chemotaxis protein CheZ.
What is the protein family that this protein belongs to?
Belongs to the CheZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK20_THAPS
Sequence: MVRVKRGNVARKRRKKILQLAKGYRGAHSRLFRVANQQVMKALRYSYVGRKQKKRVFRKLWISRINASSREKGVTYSTLINSFKKSKINLNRKMLAQIAVLDCSTFYKLIDDAKSPN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DSBB_VIBPA
Sequence: MTIFSSLNQFSKGHVSWLLLLLFIIFFEACALYFQHVMMLAPCVMCIYERVAMMGIGGAAIIGLIAPNNALFRWLGLIGWGLSSYKGLMLAMQHVDYQFNPSPFATCDLFVTFPSWAPLNQWVPWMFEAYGDCSKIVWQFFDLSMPQWLVVIFAGNLVALALIVIAQFFPVKRKNPIR
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.