PharMolix/UniProtQA huggingface dataset:
Protein: POLG_PRSVW
Sequence: LVRKSCERLYEGRMGVWNGSLKAELRPAEKVLAKKTRSFTAAPLDTLLGAKVCVDDFNNWFYSKNMECPWTVGMTKFYKGWDEFLRKFPDGWVYCDADGSQFDSSLTPYLLNAVLSIRLWAMEDWDIGEQMLKNLYGEITYTPILTPDGTIVKKFKGNNSGQPSTVVDNTLMVLITMYYALRKAGYDTKTQEDMCVFYINGDDLCIAIHPDHEHVLDSFSRSFAELGLKYDFTQRHRNKQNLWFMSHRGILIDDIYIPKLEPERIVAILEWDKSKLPEHRLEAITAAMIESWGYGDLTHQIRRFYQWVLEQAPFNELAKQGRAPYVSEVGLRRLYTSERGSMDELEAYIDKYFERERGDSPELLVYHESRSTDDYQLVCSNNTHVFHQSKNEAVDTGLNEKFKEKEKQKEKEKEKQKEKEKDDASDGNDVSTSTKTGERDRDVNVGTSGTFTVPRIKSFTDKMILPRIKGKSVLNLNHLLQYNPQQIDISNTRATQSQFEKWYEGVRNDYGLNDNEMQVMLNGLMVWCIENGTSPDISGVWVMMDGETQVDYPIKPLIEHATPSFRQIMAHFSNAAEAYIAKRNATERYMPRYGIKRNLTDISLARYAFDFYEVNSKTPDRAREAHMQMKAAALRNTSRRMFGMDGSVSNKEENTERHTVEDVNRDMHSLLGMRN
What is the function of this protein?
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the potyviridae genome polyprotein family.
What are the subcellular locations of this protein?
[Capsid protein]: Virion.
Protein: C76M7_ORYSJ
Sequence: MENSQVWLLWGALSVAVLFYLSTLRRRHAGGKPLPPGPTPLPLIGNLHLAGGTSFHHKLRDLARVHGPVMTLKLGLATNVVISSREAAIEAYTKYDRHLAARATPDTFRACGFADRSMVFIPSSDPRWKALRGIQGSHVFTPRGLAAVRPIRERKVGDLMAYLRAHAGEEVLLGQAMHTGLLNLVSFSYFSIDIVDMGSQMARDLREVVDDIISVVGKPNISDFYPFLRPLDLQGLRRWTTKRFNRVFSIMGDIIDRRLAHIRDNKPSHNDFLDSLLELMAAGKIDRVNVLDMLFEAFVAGADTMALTLEWVMAELLKNPGVMAKARAELRDVLGDKEVVEEADAARLPYLQAVLKEAMRLHPVGALLLPHFAVEDGVEVGGYAVPKGSTVLFNAWAIMRDPAAWERPDEFVPERFVERAPLLDFRGKDAEFMPFGSGRRLCPGLPLAERVMPFILASMLHTFEWKLPGGMTAEDVDVSEKFKSANVLAVPLKAVPVLIK
What is the function of this protein?
Enzyme of the diterpenoid metabolism involved in the biosynthesis of antibacterial oryzalides such as phytocassane.  Can use ent-cassadiene as substrate, but not C11-alpha-hydroxy-ent-cassadiene, ent-pimaradiene, ent-sandaracopimaradiene, ent-kaurene, ent-isokaurene, syn-pimaradiene, syn-stemarene, syn-stemodene.
What are the official names of this protein?
Ent-cassadiene C11-alpha-hydroxylase 1, Cytochrome P450 76M7.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CPPED_MOUSE
Sequence: MSAMEAADVFHRARGRTLDAFSSEKEREWKGPFYFVQGADTQFGLMKAWSTGNCDAGGDEWGQEIRLTEQAVEAINKLNPKPKFFVLCGDLVHAMPGTPWRQEQTRDLQRVLKAVDQDIPLVMVSGNHDLGNAPTAETVEEFCQTWGDDYFSFWVGGVLFLVLNSQFLYDASRCPALKQAQDHWLDQQLNIAEQKQCQHAIVFQHIPLFLQSIDEDDDYFNLTKTVRKELAEKLTRAGIRAVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGKDTHGLRVVAITAEKIVHRYYSLDELSQGGVEEDLKELLKE
What is the function of this protein?
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis.  May play an inhibitory role in glucose uptake by adipocytes (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase CPPED1, Calcineurin-like phosphoesterase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. CPPED1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGM1_ARATH
Sequence: MDEIQIASILKSSELFPIPQGVKLSYGTAGFRGDAKLLESTVYRVGILSALRSLKLGSATVGLMITASHNKVSDNGIKVSDPSGFMLSQEWEPFADQIANASSPEELVSLIRKFMEKEEIAIGENNKGAEVWLGRDTRPSGESLLRAGEIGVGSILGSVAIDIGILTTPQLHWMVRAKNKGLKATENDYFENLSTSFRCLIDLIPSSGNDKLEISKLLVDGANGVGGQKIEKLRGSLSNLDVEIRNTGRDGGVLNEGVGADFVQKEKVLPVGFGFKDVGMRCASLDGDADRLVYFYIPSDSSEKVELLDGDKILSLFALFIKEQLNALEDDEERKQSRLGVVQTAYANGASTDYLKHLGLDVVFAKTGVKHLHEKAAEFDIGIYFEANGHGTILFSESFLSWLVSKQKDLTAKGQGGSEEHKAVSRLMAVSNLINQAVGDALSGVLLVEVILQHLGWSIEKWNELYKDLPSRQIKVEVPDRTAVVTTSEETEALRPMGIQDAINSEIKKYSRGRAFIRPSGTEDVVRVYAEASTQEDADSLANSVAQLVKSFLGSS
What is the function of this protein?
Interconverts GlcNAc-6-P and GlcNAc-1-P.
What are the official names of this protein?
Phosphoacetylglucosamine mutase, PAGM, Acetylglucosamine phosphomutase, DNA-damage-repair/toleration protein DRT101, N-acetylglucosamine-phosphate mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: GSTT1_DROSE
Sequence: MADFYYLPGSSPCRSVIMTAKAVGVELNKKLLNLRAGEHLKPEFLKINPQHTIPTLVDNGFALWESRAIQVYLVEKYGKTDSLYPKCPKKRAVINQRLYFDMGTLYQSFANYYYPQVFAKAPADPEAFKKIESAFEFLNTFLEGQEYAAGDSLTVADIALVASVSTFEVAGFEISKYANVNKWYENAKKVTPGWEENWAGCLEFKKFFE
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  Has DDT dehydrochlorinase activity (By similarity).
What are the official names of this protein?
Glutathione S-transferase 1-1, DDT-dehydrochlorinase, GST class-theta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
Protein: ACP_BUCAT
Sequence: MKNIEERIKKIIFEKLDIKQEKIFNDASFIDDLGADSLDTVELIMALEEEFDIEISDEEAEKINTVQKSIDFIQKKNLKK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P14_POLVP
Sequence: MENSQTGVLCPNRCQVCSHTTYIRESSGQGGRQACRFTRFVTQPRVVSEQGIQYRSWLSDRGFPATLLSTSGGLSTTIRGHGVAVTIQGDSKSLLNFCRVAYDVFHHPVVQSEVCHGSGPATSDEITTKF
What is the function of this protein?
Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  Binds to dsRNAs without size specificity.
What are the official names of this protein?
RNA silencing suppressor p14.
Protein: VISL1_HUMAN
Sequence: MGKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLNLEEFQQLYVKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDKNKDDQITLDEFKEAAKSDPSIVLLLQCDIQK
What is the function of this protein?
Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.
What are the official names of this protein?
Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
Protein: RL34_NEIG1
Sequence: MKRTYQPSVTKRKRTHGFLVRSKTRGGRAVLAARRAKGRKRLAV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: TM141_MOUSE
Sequence: MVNLGLSRVDDAVAARHPGLEEFAACQSHAFMKGVFTFVTGTGATFGLLMFIKRKFPYPVQWSFLVSAIAGSVASYRVTSMECQKCSNLWLFLETGQLPKDISTDPHD
What are the official names of this protein?
Transmembrane protein 141.
What is the protein family that this protein belongs to?
Belongs to the TMEM141 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: O1078_RAT
Sequence: MDSSNRTRVSEFLLLGFVENKDLQPLIYGLFLSMYLVTVIGNISIIVAIISDPCLHTPMYFFLSNLSFVDICFISTTVPKMLVNIQTQNNVITYAGCITQIYFFLLFVELDNFLLTIMAYDRYVAICHPMHYTVIMNYKLCGFLVLVSWIVSVLHALFQSLMMLALPFCTHLEIPHYFCEPNQVIQLTCSDAFLNDLVIYFTLVLLATVPLAGIFYSYFKIVSSICAISSVHGKYKAFSTCASHLSVVSLFYCTGLGVYLSSAANNSSQASATASVMYTVVTPMVNPFIYSLRNKDVKSVLKKTLCEEVIRSPPSLLHFFLVLCHLPCFIFCY
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 1078, Olfactory receptor-like protein F3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOA_STRMK
Sequence: MTVTANQVLRPRGPQIERLTDTRAKVVIEPLERGYGHTLGNALRRVLLSSIPGFAITEVEIDGVLHEYTTVEGLQEDVLEVLLNLKDVAIRMHSGDSATLSLSKQGPGVVTAADIKVDHNVEILNGDHVICHLTKDTAINMRLKIERGFGYQPAAARRRPDEETRAIGRLVLDASFSPVRRVAYAVEAARVEQRTDLDKLVIDIETNGTIDAEEAVRTAADILSDQLSVFGDFTHRDRGAAKPANNGVDPVLLRPIDDLELTVRSANCLKAESIYYIGDLIQKTEVELLKTPNLGKKSLTEIKEVLAQRGLSLGMKLENWPPAGVASHGMLG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: PANC_CHLPB
Sequence: MQIINDPTEMQKTAESLRLKHQFIAVVMTMGALHEGHLSLIKLAKERAGSVILTIFVNPRQFGPEEDFQRYPRPLEKDASMARSAGVDYLFAPDPELIYPEAFQTQVSTGDIATRFEGAARPGHFDGMATVVLKLLLLSKAHLAVFGEKDAQQLAVIKQMVRDFNIDTTILGAPTVRESDGLAISSRNIYLSSEERKQATVLNESMCRARELLHMKQTDCKLIIEEVTKVIASAPDAIIDYATIVDESNFRETAILKPDINYLLLLAVKIGSTRLIDNGVLRVSQQDV
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRC_LACAC
Sequence: MKTVIKNGTVYQNGRLIHADVLIEDQKIKVIGTNLTGDKEFDATGKLVAPGLVDVHVHYREPGQTYKEDIRTGSEAAARGGFTTVGAMPNVTPVPNTPELMEKMVKKNQEKGIVHIFQYGPITNDETTDIIPDYAALKKAGAFALSNDGHGVQTAQTMYLAMQKAKANNLIIATHAQDDSLFNHGIVNEGKKAEELNLPPVTELAETTQIARDLLLAQKTGVHYHICHVSTKTSVELVRMAKARGINVTCEVAPHHILLTDDDIPKDNGYYKMNPPLRNKEDQAALLVGLLDGTIDLIATDHAPHAKKEKQGGMKGAAFGITGSETAFSTLYTKFVKKDKVFTLEQLLSWLSDKPAEAFGLKDAGVLEPGKNADIAIFDIEHEATIEEKDYKSKGVNTPFTGQKVYGETVMTMVNGKVVYQRGTK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: ZN765_HUMAN
Sequence: MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKEFSSTAQGNREVFHAGTSQRHESHHNGDFCFQDIDKDIHDIEFQWQEDERNGHEALMTKIKKLTGSTERYDQNYAGNKPVKYQLGFSFHSHLPELHIFHTEEKIDNQVVKSIHDASLVSTAQRISCRPETHISNDYGNNFLNSSLFTQKQEVHMREKSFQCNDSGKAYNCSSLLRKHQLIHLGEKQYKCDICGKVFNSKRYVARHRRCHTGEKPYKCNECGKTFSQTYYLTCHRRLHTGEKPYKCEECDKAFHFKSKLQIHRRIHTGEKPYKCNECGKTFSQKSYLTCHRRLHTGEKPYKCNECGKTFSRKSHFTCHHRVHTGEKPYKCNECSKTFSHKSSLTYHRRLHTEEKPYKCNECGKTFNQQLTLNICRLHSGEKPYKCEECDKAYSFKSNLEIHQKIHTEENPYKCNECGKTFSRTSSLTYHHRLHTGQKPYKCEDCDEAFSFKSNLERHRRIYTGEKLHV
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 765.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL28_RUBXD
Sequence: MAKVCYSCGKGPSFGNARSHSLRATRRRWNPNLQKVRIREGGATKRVWVCASCLKGFKVQKAVRPVPAAEA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: CH60_BRECH
Sequence: MAKQVKFSEDAPRSMLRGVETLPNAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIPKEIELEDAYENMGAQLVKEVATKTNGIAGDGTTTATVLAAAMIREGLKNVAAGANPMVIRRGMEKAVGAAVEEIKSIAKPVENKSSIAQVAAISADDQEVGNLIAEAMEKVGKDGVITVEESKGFVTELEVVEGMQFDRGYASPYMITDTDKMEAVLNNPFILITDKKISNIQEVLPVLEQVVQSGKPLLIIAEDVEGEALATLVVNKLRGTFTAVAVKAPGFGDRRKAMLQDIAALTGGEVITEELGLDLKSTKLEQLGRAGKIVVTKENTTVVEGAGDKANIESRVAQIRQQIEDTTSDFDREKLQERLAKLAGGVAVIKVGAATETELKEKKLRIEDALNSTRAAVEEGIVPGGGTTLINAIKAVEGVKVEGEEAVGVHIVLRSLEEPVRQIAANAGLEGSVIVERLKKEPVGIGFNAATEEYVNMLEAGIVDAAKVTRSALSNAASVAAMFLTTEAVIADKPEENKAPMGMPDMGGMGGMGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA1_STRA1
Sequence: MRKIIINGGKQLTGEVAVSGAKNSVVALIPATILADDVVVLDGVPAISDVDSLVDIMETMGAKIKRYGETLEIDPCGVKDIPMPYGKINSLRASYYFYGSLLGRYGQATLGLPGGCDLGPRPIDLHLKAFEAMGASVSYEGDSMRLATNGKPLQGANIYMDTVSVGATINTIIAAAKANGRTVIENAAREPEIIDVATLLNNMGAHIRGAGTDVITIEGVKSLHGTRHQVIPDRIEAGTYIAMAAAIGRGIKVTNVLYEHLESFIAKLDEMGVRMTVEEDSIFVEEQERLKAVSIKTSPYPGFATDLQQPLTPLLLTAEGNGSLLDTIYEKRVNHVPELARMGANISTLGGKIVYSGPNQLSGAPVKATDLRAGAALVIAGLMAEGRTEITNIEFILRGYSNIIEKLTSLGADIQLVEE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1, Enoylpyruvate transferase 1, UDP-N-acetylglucosamine enolpyruvyl transferase 1, EPT 1.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_RICTY
Sequence: MLKLLSEIGPVIAFFAGFFYGGGIQSATLYMLITSIICITLCYIIDKKVSKLSIISSTVLFVSGIITLISGDSMYIKIKPTILYVIFGIIFLMSGIRKNPFIKYALESIVRLKEESWIILSYRTAAFFFFMAVVNEVVWRNFSDETWVKFKVFGVIPITFIFILLQLPLLLKNKLPDSKI
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL5_MYCSS
Sequence: MTTAEKTLPRLKQRYREEIRESLQQQFGYANVMQIPGVVKVVVNMGVGDAARDAKLINGAVNDLALITGQKPEIRRARKSIAQFKLREGMPIGARVTLRGDRMWEFLDRLVAIALPRIRDFRGLNPKQFDGTGNYTFGLTEQSMFHEIDVDSIDRPRGMDITVVTSATTDDEGRALLRALGFPFKEN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RS7_NEIG1
Sequence: MPRRREVPKRDVLPDPKFGSVELTKFMNVLMIDGKKSVAERIVYGALEQIEKKTGKAAIEVFNEAIANSKPIVEVKSRRVGGANYQVPVEVRPSRRLALAMRWVRDAARKRGEKSMDLRLAGELIDASEGRGGALKKREEVHRMAEANKAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: UROM_HUMAN
Sequence: MGQPSLTWMLMVVVASWFITTAATDTSEARWCSECHSNATCTEDEAVTTCTCQEGFTGDGLTCVDLDECAIPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEPGLSHCHALATCVNVVGSYLCVCPAGYRGDGWHCECSPGSCGPGLDCVPEGDALVCADPCQAHRTLDEYWRSTEYGEGYACDTDLRGWYRFVGQGGARMAETCVPVLRCNTAAPMWLNGTHPSSDEGIVSRKACAHWSGHCCLWDASVQVKACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTRFRSGSVIDQSRVLNLGPITRKGVQATVSRAFSSLGLLKVWLPLLLSATLTLTFQ
What is the function of this protein?
In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals (By similarity).  Protects against urinary tract infections by binding to type 1 fimbriated E. coli (PubMed:11134021, PubMed:32616672).  Binds to bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E. coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation (PubMed:11134021, PubMed:32616672).  Also promotes aggregation of other bacteria including K. pneumoniae, P. aeruginosa and S. mitis and so may also protect against other uropathogens (PubMed:32616672).
What are the official names of this protein?
Uromodulin, Tamm-Horsfall urinary glycoprotein, THP.
What are the subcellular locations of this protein?
Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization (PubMed:22776760). Secreted into urine after cleavage (PubMed:18375198, PubMed:26811476). Colocalizes with NPHP1 and KIF3A (PubMed:20172860). SUBCELLULAR LOCATION: [Uromodulin, secreted form]: Secreted. Note=Detected in urine.
Protein: PLS1_PHAJA
Sequence: FLSLIPHAINAISAIANHF
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Phylloseptin-J1, PLS-J1, PS-J1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LEUD_ACIBC
Sequence: MKAYTVEQGIVAPLDRANVDTDLIIPKQFLKSIKRTGFGDNLFDELRYLDEGYPGQDNSVRPKNPDFVLNQPRYQGATVLIARTNFGCGSSREHAPWALNEYGFRTVIAPSFADIFFNNCFKNGMLPVILPEDIVDQLFKECAAQEGYQLTIDLAAQEVRTPTGEAFKFEVDPFRKHCLLNGLDDIGLTLQNADAIRAYEEKTKQVRPWVFQEIN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: ACKA_BUCAI
Sequence: MDKKLNNLILVLNCGSSSIKFAILNPDNKEKYLSGSVECLFLLETYITWQCLGTKHKKKIGANVNHKDALNFIIEQVFSQQKDIFKNLIGVGHRVVHGGTKIKKSTLIDSNIIKCIQDASSFAPLHNPANLIGIKMIIEKYPSLSRKNIAVFDTSFYCNMPETSFLYAIPYNFYKKYGIRRYGAHGISHNYVAHRASLMLNKQFKSLNIITCHLGNGSSISAICNGICVDTSMGLTPLEGLVMGTRSGDLDPSIIFFMNNHLNLSIDKIETILNKKSGLLGLSGISSDFRYFEKKYYCKKHAKRSVDIFCHRLSKYIAAYTSVLENRLDAVIFTGGIGENVPLIRELVFSRLSLLGFKINSNLNLSTIGGKSGLITEDNSTPVFVITTDEELAIAQETNSIINRK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNB_CITK8
Sequence: MTDNLQLTQLVETCRWIGAKGWAPATGGNMSVRQDDAFCWLSESGKDKGNLTTDDFLQVEIATSHAPSGRKPSAETGLHTLIYHLFPQANAVLHVHTANATVLSRIVKTPELYISGFEMQKSLSGQTTHLDTVCVPVFDNDQDIDALASRIAHYAQERSLNYGFLLRGHGLTCWGRSVEEARRHLEGLEFLFECEMRLRQLERL
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: GFAP_RAT
Sequence: MERRRITSARRSYASSETMVRGHGPTRHLGTIPRLSLSRMTPPLPARVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTTNSARLEVERDNLTQDLGTLRQKLQDETNLRLEAENNLAVYRQEADEATLARVDLERKVESLEEEIQFLRKIHEEEVRELQEQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDVASRNAELLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQSLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
What is the function of this protein?
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
What are the official names of this protein?
Glial fibrillary acidic protein, GFAP.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with intermediate filaments.
Protein: SSPD_BACSU
Sequence: MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVGGEMTKRLVQQAQSQLNGTTK
What is the function of this protein?
SASP are bound to spore DNA.  They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation.  They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.
What are the official names of this protein?
Small, acid-soluble spore protein D, SASP.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta-type SASP family.
Protein: SYT_ORITI
Sequence: MIDIILPDGSVKQYKIGVTGQEIIQSLSISLFKKTIAVAVNNELMDLYIPIINTATVKAITIDSVQGIEILRHDTAHILAQAVKKLFPDTQVVIGPVIKDGFYYDFARDKPFTSKDLEIIEQEMQDIITKNDLIQREVWLRAKAIEFFKQQKEFYKVKLIEEIPESEEISIYRQGNFVDLCRGPHSPSTGYCAKYFKLTKVSGAYWRGNSKNESLQRIYGTAWGKKSDLDSYLHRLSEAQKRDHRKLGRELELFHFQDEAQGMPFWHSKGWTIFKIIKDYISCQIQRAGYIEVNTPMVLNQKLWEKSGHWEKFRENMFTLDTNAAEQDHNLIKDSIETKCALALKPMNCPGHIQIFNYTIKSYRDLPLRMAEFGSCHRYEPSGALYGLMRVRSFVQDDAHIFCTEDQITDETIKFCHLLKQVYQDFGFPEVKIKFSDRPEKRAGTDKIWDKAEQALIHAIQTLGEEYTINRGEGAFYGPKLEFILTDAIGREWQCGTLQVDFVLPERLNASYISSEGSKKRPVILHRAILGSFERFIGILIEHYSGKLPIWLAPIQVAVVSITDEAVNYAKQLHQELIDNNIRSTLDISNQKINYKIRNFFTAKVPLIAILGKKESESGKIAIRTLGSQEQHVISSSELIAHIRKNKK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_SHEFN
Sequence: MKIGIIGAMEPEVVHLVQAIVDPVHTTIAGIEFISGSIAGKDVVVTRSGIGKVAASIATTLLIEKFAATHVINTGSAGGFVDSLAIGDIVISSEVRHHDVDVTAFGYEIGQMAQQPAAFMPDSTLVNAAKSAVAELGEVKAIEGLICTGDSFICDPVRTKVMRENFPTMAACEMEGAAIAQVCHQFNVPFVVIRSLSDNANNDSPVDFDSYIIKAGMHSAMMVIALLQQL
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.