PharMolix/UniProtQA huggingface dataset:
Protein: ALG10_ARATH
Sequence: MGKLAVAAITSLWVIPMSIIVNHIVPEPYMDEIFHVPQAQQYCNGNFRSWDPMITTPPGLYYLSLAHVASLFPGMLLMENTSQSFSEACSTSVLRSTNAVSAVLCGVLVYEIIRFLGPNLSDRKATFMALVMSLYPLHWFFTFLYYTDVASLTAVLAMYLTCLKRRYVLSALFGTLAVFIRQTNVVWMLFVACSGILDFTLDSSKQKGKQEVNQELHQSSNKKGATLRSNLRKRKSDISSDTSDPFNHGQTVPSTEDTSDLVYDIYTVISTSWNLKWRILIKFSPFIFVVVAFGIFILWNGGIVLGAKEAHVVSLHFAQIMYFSLVSALFTAPLHFSVNQLRHQFHQLHRNWSLSLILTLVALVAGFVSVHFFSLAHPYLLADNRHYPFYLWRKIINAHWLMKYILVPVYVYSWFSILTLLAKTRRQTWILVYFLATCGVLVPTPLIEFRYYTIPFYLFMLHSCVRSSSFATWLLIGTIFVSINVFTMAMFLFRPFKWSHEDGVQRFIW
What is the function of this protein?
Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.  Can complement an ALG10-deficient yeast mutant.
What are the official names of this protein?
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Alpha-1,2-glucosyltransferase ALG10 homolog, Protein HOMOLOG OF YEAST ALG10.
What is the protein family that this protein belongs to?
Belongs to the ALG10 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TRUB_AYWBP
Sequence: MNGFFLVNKPEKMTSHDVVFQIKKKFHFDKVGHTGTLDPLASGLLIVCVGKATKLAFLFDKLSKTYQGTFLFNKHYDTLDVKGKLLDTKNIPLNDFAIQTSFASFHQKKYWQIPPMFSAVKIKGQKMYRLARQNQVVDIPPREVFIHHFEKKSLFCHDQVDFLVHVSKGTYIRSLARDLALQLNTYGALLRLQRTAIGTHLLQNAKTIENLELNDLILDSIFFASYDELILNDYLIKLVKNGTYLDQRQIITQKPFIVKDSNKNFVAYYDILDENKYYPRYFF
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: LSM1A_ARATH
Sequence: MSWAAPDDIFFSTSLAAYLDKKLLVLLRDGRKLMGLLRSFDQFANAVLEEAYERVIVGDLYCDIPLGLYIIRGENVVLIGELDVEKEELPAHMVQVPEAEIKRAQKAEKEEMLLKGTMRKRMEFLDLD
What is the function of this protein?
Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by promoting decapping and leading to accurate 5'-3' mRNA decay.  LSM1A and LSM1B are essential for the formation of the cytoplasmic LSM1-LSM7 complex which regulates developmental gene expression by the decapping of specific development-related transcripts (PubMed:23221597, PubMed:23620288).  Required for P-body formation during heat stress (PubMed:23221597).
What are the official names of this protein?
Sm-like protein LSM1A, AtLSM1a.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, P-body. Note=Translocates from cytosol to P- bodies upon heat stress.
Protein: METL_AQUAE
Sequence: MKNIVVTPMTFEPVYEQDAEIVERKGIGHPDTICDYLAEELSVALSKLYIERFGAIMHHNVDKALLVGGEANPVFGGGEVISPIEIYLVGRALKEYKGVTIPAEELAIEVAREWLKDNIRNLDPDTHVIIKPRIKPGSKDLVDLFLRFQQKGEVPLANDTSFGVGFAPLDDLERIVFETEQLLNSPSFKENHPYVGEDIKVMGVRIKDKVRITIACAFVSKYVENIQDYLEKKEHVRRIVEEMAQGLTQRQVEVFINTADDPERESVYITVTGTSAEQGDDGQVGRGNRVNGLITPYRPMSLEAAAGKNPVSHIGKIYNVVANVIADRVVSEIEEVEEAYCYLVSQIGKPINEPQVCDVKVRTKKDLKSLEEEIKRIAQEELEKMPETWKKFLNREYAVA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
What are the official names of this protein?
Probable S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase 2 family.
Protein: RS13_PSE14
Sequence: MARIAGVNIPDNKHTVISLTYIYGVGRTTAQKICATTGVNPAVKIKDLSDEQIEQLRGEVAKFTTEGDLRREINMKIKRLMDLGCYRGLRHRRGLPVRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: DAPA_MICAN
Sequence: MSETTYFGRVITAMVTPFTVEGQVNYALVEKLADYLVTHGSDGIVVCGTTGESPTLSWQEEYELFSIVKKAVNGRGKVIAGTGSNSTSEAIEATQQAAKLGLDGSLQVVPYYNKPPQEGLYEHFLTIAKACPDLPVMLYNIPGRTGQNMTPETIIKLAAVDNIVAVKEASGNLEQTCKIYCHTPENFAIYSGDDFLTLPLMTCGAVGVVSVASHLVGEEIQGMIQALLTGDAAKAIEINLKLFPLFKGLFCATNPIPIKAALNLVGWEVGGLRLPLCSLSPELEEGLAKIMQELALI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1C_MARPO
Sequence: MEKQKLIDMEGVVIESLPNATFRVYLDNGCIVLTHISGKIRRNYIRILPGDRVKVELSPYDLTKGRITYRLRAKSSNN
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HIS6_NITSB
Sequence: MQEYFAKRIIPCLDVDKGRVVKGVNFVGLKDAGDPVEVAKRYNEEGADEITFLDITATYEERDTIVHIVEEVAKEVFIPLTVGGGIRELDDIYKLLAVGCDKVSINSAAVKKPEFVDEAAKRFGSQCIVVAIDAKRVGDGWHVFTAGGRHDSGKDAIEWAKEVYDRGAGEILLTSMDADGTKAGYDLELTRAISDAVDIPVIASGGAGTMEHIKDAFTKGHADAALAASIFHFKEIDIMELKHYLHNEGIPVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADA_SALCH
Sequence: MEQVVIVDAIRTPMGRSKGGAFRNERAEDLSAHLMRSLLARNPSLTAATLDDIYWGCVQQTLEQGFNIARNAALLAEIPHSVPAVTVNRLCGSSMQALHDAARMIMTGDAQVCLVGGVEHMGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLSRLHGISREMQDQFAARSHARAWAATQSGAFKTEIIPTGGHDADGVLKQFNYDEVIRPETTVEALSTLRPAFDPVSGTVTAGTSSALSDGAAAMLVMSESRARELGLKPRARIRSMAVVGCDPSIMGYGPVPASKLALKKAGLSASDIDVFEMNEAFAAQILPCIKDLGLMEQIDEKINLNGGAIALGHPLGCSGARISTTLINLMERKDAQFGLATMCIGLGQGIATVFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP2Q_BACSU
Sequence: MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQSVSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAKEEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHADGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLNFMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESSTTEDTEQS
What is the function of this protein?
Involved in forespore engulfment and required for anchoring membrane proteins on the forespore side of the septal membrane.  Forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end.  This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling.
What are the official names of this protein?
Stage II sporulation protein Q.
What are the subcellular locations of this protein?
Forespore membrane; Single-pass membrane protein. Note=Localizes to the engulfing septal membranes.
Protein: YLA3_SCHPO
Sequence: MSHKEPSAAETSTVVHSEEDKAFCIGTGAVISEEREKEVLKNLQNSLTGKTAEENLNDEANHTSSDKSKSEDYQPSNVNVWALRKEKMIPKKHSHVKQEKRFSKSLQLQDPNVWPSPEIAEKQVEDRKLSDDSQKPLAPKANGKEKWVTITPNFTHTPISNRKSSRSRNDGSRRNGNGRRRGNYSSHGSNKRQTNYSREKDASRSIDSSNPSAEYRDDINNTFGSQTVSSANGKEVPQTSEDSSSQAPHHSSSSGHAPSQQGGNKHSYKKSDSQQSFHHKGRNTRKGQRHNNGFYRNIANNIQGPFPNYPVVVNGNGVNPYLCDVQAFLTSQLEYYFSIENLCKDMFLRKHMDDEGYVPLAFLASFNRIKSFSTDLNLLHAACKASDIIDVAIDLQSPMSIKVRRKETWSPWILPSESRLKFEMAKYPQINSSSSMSPLASSISNLTISPPFIPSSVDSIIKRDVQTEVEDKLTV
What are the official names of this protein?
Uncharacterized HTH La-type RNA-binding protein C1527.03.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF1A_ARCFU
Sequence: MAKEKEHINVAFIGHVDHGKSTLIGRLLYETGEIPEHIIEKMRKEAQEKGKATFEFAWVMDRLKEERERGVTIDVAHRKFQTDKYYITIVDCPGHRDFIKNMITGASQADAAVLVMDVVEKVQPQTREHIFLARTLGINQIIVAINKMDRVNYDQKEYEAAKEAVSKLLKMVGYKVDEIPFIPVSAYYGDNVAKKSDKTPWYNGPTLLEAFDLLKPPEKLVDKPLRIPIQDVYSISGVGTVPVGRVESGVLRVGDKVVFEPAGVSGEVKSIEMHHEPIQEAYPGDNIGFNVRGVSKKDIRRGDVAGHPDNPPTVVKDFTAQLVVLQHPTAITVGYTPVVHAHTAQIACRFVELQKKIDPRTGQVKEENPQFLKTGDAAIVKLEPTRPMVIERVKDIPPMGRFAIRDMGMTIGAGMVLDLTPRK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha, Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H32_TOBAC
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRFRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.2.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: FRG1_MOUSE
Sequence: MAEYSYVKSTKLVLKGTKAKSKKKKSKDKKRKREEDEETQLDIVGIWWTVSNFGEISGTIAIEMDKGAYIHALDNGLFTLGAPHREVDEGPSPPEQFTAVKLSDSRIALKSGYGKYLGINSDGLVVGRSDAIGPREQWEPVFQDGKMALLASNSCFIRCNEAGDIEAKNKTAGEEEMIKIRSCAERETKKKDDIPEEDKGSVKQCEINYVKKFQSFQDHKLKISKEDSKILKKARKDGFLHETLLDRRAKLKADRYCK
What is the function of this protein?
Binds to mRNA in a sequence-independent manner.  May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits.  May be involved in mRNA transport.  May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B.
What are the official names of this protein?
Protein FRG1, FSHD region gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the FRG1 family.
What are the subcellular locations of this protein?
Nucleus, Cajal body. Nucleus, nucleolus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line. Note=Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post-differentiation. Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation.
Protein: RRF_BRADU
Sequence: MMPTGNFDLNEVKRRMQGAVQSLKHELGGLRTGRASASMLDPVQVEAYGSHMPLNQLATVSVPEPRLISVQVWDKSMVKAVEKAIVDSNLGLSPATEGQVLRLRIPELNEERRKELVKVAHKYAEAAKVAARHVRRDGLDVLKKLEKNHEMSEDDQKRHADEVQKVTDGTIAEIDQLLAAKEKEILTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB2_BURP0
Sequence: MANHPLTLEKDGFIVTTLDAAMAAAQKNSLWYMTFGLACCAVEMMHAAGARYDMDRFGMIPRASPRQCDLMIVAGTLTNKMAPAMRRVYDQMAEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALVYGLMQLQRKVAERSTHSRPKLFARP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 2, NADH dehydrogenase I subunit B 2, NDH-1 subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FFSH_ASPFV
Sequence: MSEAEKKASQDAQHKEPMADSETQLDSDSAPSSQAEKPAKTKYPLSFWLAFGALCLTGLISAMEGSIVSTSLPSIIAELKAAFQPLYGQLADLWGRRYVMILATAIFLLGSGICGGANSMDMLIWGRAVQGIGAGGINMLVDLIICDLVPMRERGNFIGLLFLFVSIGTTSGPIIGGALTDNTTWRWVFYINLPMGGAALVLLVLFLQVKWKKELSTRDRLKRIDVVGNAILVGATFSILYALTYGGTRYPWSAANIVAPFVLGFVGLGIFIAWESNKRWCPYPVMPLHHFNSRTASASFFISFMTMILAFWVVYFYPVYFQSVLGNTPTISGVHLLPFEVSFPIFAAVGGGLVSKTGRYKPIHMVATSIVTIAIGASSVLTQHTHKAAWAVLQIFIGMGLGSLISTTLQAVQAGLPESETAASTATWAYMRSLGTIWGVSVPAAIFNNRFDQLSGQLDPSIRDNFVRGQAYEHATAQFVQSFEPATREVVIGAYTDALRRVWLVSIAFGAVTVLSTLFEKELTLRTELDSEFGLAEKKGDAKGDVERGEGQNDSREGGQNENV
What is the function of this protein?
MFS-type efflux transporter; part of the gene cluster that mediates the biosynthesis of the cytotoxic leucine-containing cytochalasans, including aspochalasin C, aspochalasin E, TMC-169, flavichalasine F, aspergillin PZ, aspochalasin M and flavichalasine G (PubMed:32913332).  FfsH might be involved in the excretion of cytochalasans (Probable).
What are the official names of this protein?
MFS-type efflux transporter ffsH, Cytochalasans biosynthesis cluster protein ffsH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNLJ_STRGC
Sequence: MKDRMSELVSLLNRYAHEYYTKDAPSVSDSEYDQLYRELVSLEEQYPNEILPESPTHRVGGKVLDGFEKYQHQYPLYSLQDAFSRAELVAFDERVRKEFPDASYLCELKIDGLSISLAYENGILVAGATRGDGSIGENITENLKRVKDIPLTLPEPLTITVRGECYMPKASFDAVNQLRQENGEAEFANPRNAAAGTLRQLDTSVVAKRNLATFLYQEASPTSEATQEDVLEKLSQLGFSVNEKRVLASTIDQVWDFIEKVGQERDKLPYEIDGIVIKVNHLAAQEELGFTVKAPKWAIAYKFPAEEKEAQLLSVDWTVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYIREKDIRKDDTVIVYKAGDIIPAVLRVVEGKRVSDEHLDVPSKCPSCQSDLLHFEDEVALRCINPLCPAQIMEGLAHFASRDAMNISGLGPAVVEKLFAKDLVRDVAGIYRLNIEDLLQLENFKEKSANKLYNAIQASKSNSAEKLLFGLGIRHVGSKASRILLEKFHDIPSLAQAEQEEIVSIDSLGMVIAKSLHSYFAQEGTQILLKELEEAGVNLAYLGEKAAADAVLSGKTVVLTGKLETLTRTQAKEKLLRLGANVAGSVSKKTDLVIAGADAGSKLAKAQELGIEIQDEAWLEQL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: BIOD_CLOBH
Sequence: MARGIFITATGTDIGKTYVTALIIKRLRETNINCGYYKAALSGAERRDGKLIAGDANYVYNIANIKGDPNDAVSYIFQQAVSPHLAAKLNNVEISMERIKKDFYSIKNKYDYITVEGSGGIVCPISTGKERIMLHNIIKIFKLPAIVVADAGLGTINSTILTLQYMKEKNISVKMILLNNYNHKDIIHIENKGYLSDNLLIPVYTCNKNANNLEIPVEKLIEIYEEI
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARBK1_BOVIN
Sequence: MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL
What is the function of this protein?
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity).  Key regulator of LPAR1 signaling (By similarity).  Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity).  Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity).  Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (PubMed:21659505).  Inhibits relaxation of airway smooth muscle in response to blue light (By similarity).
What are the official names of this protein?
Beta-adrenergic receptor kinase 1, Beta-ARK-1, G-protein-coupled receptor kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Postsynapse. Presynapse.
Protein: PCNA2_THEKO
Sequence: MTFEIVFDSAREFESLIATLEKFFDEAVFQVNMEGIQMRAIDPSRVVLVDLNLPEMLFSKYSVESEEAIAFDLKRFLKVLKLARSRDTLVLRKGGENFLEVGLLGDENTWFKLPLIDANTPEIEIPSLPWTVKAVVLAGALKRAVKAAKLVSDSIYFMATPEKLTFKAEGNDSEVRTVLTMEDPGLLDLEHKMTKAKSAYGVAYLEDILRSLADADEVIIRFGFDIPLLLKYMVRDAGEVSFLIAPRVEEGRS
What is the function of this protein?
Sliding clamp subunit that acts as a moving platform for DNA processing.  Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
What are the official names of this protein?
DNA polymerase sliding clamp 2, Proliferating cell nuclear antigen homolog 2, PCNA 2.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
Protein: MET22_MOUSE
Sequence: MGPAMDEVTFKSDTVLSDVHLYTPNQRHLMVRLNGMGQPVFLSQFKLLWSRDSWTDSGAEDSGPTDVSTEEMPPAGSGSGHSHEDLSLQAGDDNTIQEGLSVPLDEDGDLDVVRRPRAASDPNPAEPARDKVHPTILAQEEDDLVGDQEYESCPHSIIKIEHTMATPLEDVGKQVWRGALLLADYILFRRDLFQGCTVLELGAGTGLASIVAATMAHTVYCTDVGTDLLAMCQRNVALNSHLTATGGGVVKVKELDWLKDNLCTDPKAPFSWSEEEIADLYDHTTVLLAAEVFYDDDLTNALFNTLSRLVHRLKNACTAIFSVEKRFNFTLRHLDVTCEAYDHFRASLDSLEKLADGRLRFMVEPVEASFPQLLVYERIRQLELWKIVVEPAA
What is the function of this protein?
Protein N-lysine methyltransferase.  Trimethylates KIN at Lys-135 (in vitro).
What are the official names of this protein?
Methyltransferase-like protein 22.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL22 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AZOR2_MESFL
Sequence: MKKVLVINSSVSQLNNSDSLAMSNMFIEEYKKMNPNDEIINLDLNETKMSQKTLTRNNIAEYFNQEDSFDFIEQLKSVDKIVLNFSMVNWGIPAILKNYIDHITIANLTFTYKGSTDGNAIGLLSNIQDVQILATKGGTGTPNSAFTEYVKNIWEFLGAKVKSEIIINEMMDIPPYAEQSPIENLEKVKEQILKAAKNF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 2, Azo-dye reductase 2, FMN-dependent NADH-azo compound oxidoreductase 2, FMN-dependent NADH-azoreductase 2.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: RAP1A_BOVIN
Sequence: MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL
What is the function of this protein?
Induces morphological reversion of a cell line transformed by a Ras oncogene.  Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner.  Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes.  Plays a role in nerve growth factor (NGF)-induced neurite outgrowth.  Plays a role in the regulation of embryonic blood vessel formation.  Involved in the establishment of basal endothelial barrier function.  May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions (By similarity).
What are the official names of this protein?
Ras-related protein Rap-1A, GTP-binding protein smg p21A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Early endosome. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions. Colocalized with RAPGEF2 in the perinuclear region (By similarity).