PharMolix/UniProtQA huggingface dataset:
Protein: IBOA_AMAMK
Sequence: MDVALEDNHIALLQHRAKNSGNTVLFKLPILRGSEPPQEWNHITVAEFAAEVDRVAIFVMTELKARGIPPRSAVTVLYSGSRYQDLIYAIALARASYIPQMCPHILTHPGVIFALMEKAGSKIILYDPSLEPATTDCPYPKMALNPIETIDSSSTINSDSALPTIEDLSSGHADVCFFYLTSGSTSGSPKVVPLTQKFVSTYYKTQFGIWLDGRRFDTQNAFLSRGSICAVAPIIQYFGCLYTGSCIVQPSKMRFSTEELLTLVNVCGLNRMTTFGTWLAPHIQAAKKDPAALKLLQEMRTVSYGGVPISIADDDWCFQNGIPLMDMYATTECGTLMVSAPGKPARFMQPVPGISYRFDPFTDTTTGADNPASTQLLKLILLADSPQIPQPQLLSEDGNFHTGDLFEKQLDGSYLFRGRGDDWIKSEDSRFIDTKAIEEKINDVCSDLVKGCIVVGHLRPSPALFIEAYHDSISTISEDGLKELVLRRLEDFNARQLKHERITDKRLIFIVDEGNLPRTV
What is the function of this protein?
AMP-binding domain-containing enzyme; part of the gene cluster that mediates the biosynthesis of the psychoactive metabolites ibotenic acid and muscimol (PubMed:32233056).  The first committed step is glutamate hydroxylation by the 2-oxoglutarate-dependent dioxygenase iboH, and the last step is decarboxylation of ibotenic acid to muscimol by the decarboxylase iboD (PubMed:32233056).  The order of the intermediate reactions is somewhat ambiguous (Probable).  IboA likely activates the carboxylic acid at position 5 to introduce an amide bond, and the flavin monooxygenase iboF generates the N-O bond (Probable).  There are several options for the latter step (Probable).  One option is that iboF directly hydroxylates the amide nitrogen formed by iboA to produce a hydroxamic acid species (Probable).  Another option is that iboF hydroxylates an external N-containing compound, whose resulting N-O bond is subsequently introduced into the hydroxyglutamate scaffold (Probable).  The paralogous PLP-dependent cystathionine gamma-synthase-like enzymes iboG1 and iboG2 are likely involved in substitution of the OH group at position 3 by the O-N moiety (Probable).  The first cyclic intermediate is most probably tricholomic acid which is likely desaturated to ibotenic acid by the cytochrome P450 monooxygenase iboC (Probable).
What are the official names of this protein?
AMP-binding domain-containing enzyme iboA, Ibotenic acid biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: GLL13_CHICK
Sequence: MRILQLLFAIVVILLLQDAPARGFSDSQLCRNNHGHCRRLCFHMESWAGSCMNGRLRCCRFSTKQPFSNPKHSVLHTAEQDPSPSLGGT
What is the function of this protein?
Has bactericidal activity.
What are the official names of this protein?
Gallinacin-13, Gal-13, Beta-defensin 13, Gallinacin-11, Gal-11.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule.
Protein: GLYC_JUNIN
Sequence: MGQFISFMQEIPTFLQEALNIALVAVSLIAIIKGVVNLYKSGLFQFFVFLALAGRSCTEEAFKIGLHTEFQTVSFSMVGLFSNNPHDLPLLCTLNKSHLYIKGGNASFKISFDDIAVLLPEYDVIIQHPADMSWCSKSDDQIWLSQWFMNAVGHDWYLDPPFLCRNRTKTEGFIFQVNTSKTGINENYAKKFKTGMHHLYREYPDSCLDGKLCLMKAQPTSWPLQCPLDHVNTLHFLTRGKNIQLPRRSLKAFFSWSLTDSSGKDTPGGYCLEEWMLVAAKMKCFGNTAVAKCNLNHDSEFCDMLRLFDYNKNAIKTLNDETKKQVNLMGQTINALISDNLLMKNKIRELMSVPYCNYTKFWYVNHTLSGQHSLPRCWLIKNNSYLNISDFRNDWILESDFLISEMLSKEYSDRQGKTPLTLVDICFWSTVFFTASLFLHLVGIPTHRHIRGEACPLPHRLNSLGGCRCGKYPNLKKPTVWRRGH
What is the function of this protein?
Forms the virion spikes together with glycoprotein G1.  The glycoprotein spike trimers are connected to the underlying matrix.  Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm.  Membrane fusion is mediated by irreversible conformational changes induced by acidification.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: Y5659_ARATH
Sequence: MKNKTNLGLSVFFFFICLVSVTSDLEADRRALIALRDGVHGRPLLWNLTAPPCTWGGVQCESGRVTALRLPGVGLSGPLPIAIGNLTKLETLSFRFNALNGPLPPDFANLTLLRYLYLQGNAFSGEIPSFLFTLPNIIRINLAQNNFLGRIPDNVNSATRLATLYLQDNQLTGPIPEIKIKLQQFNVSSNQLNGSIPDPLSGMPKTAFLGNLLCGKPLDACPVNGTGNGTVTPGGKGKSDKLSAGAIVGIVIGCFVLLLVLFLIVFCLCRKKKKEQVVQSRSIEAAPVPTSSAAVAKESNGPPAVVANGASENGVSKNPAAVSKDLTFFVKSFGEFDLDGLLKASAEVLGKGTFGSSYKASFDHGLVVAVKRLRDVVVPEKEFREKLQVLGSISHANLVTLIAYYFSRDEKLVVFEYMSRGSLSALLHGNKGSGRSPLNWETRANIALGAARAISYLHSRDATTSHGNIKSSNILLSESFEAKVSDYCLAPMISPTSTPNRIDGYRAPEVTDARKISQKADVYSFGVLILELLTGKSPTHQQLHEEGVDLPRWVSSITEQQSPSDVFDPELTRYQSDSNENMIRLLNIGISCTTQYPDSRPTMPEVTRLIEEVSRSPASPGPLSD
What is the function of this protein?
Might be involved in early recognition of growth promoting fungi.  Appears to be specific for P. indica.
What are the official names of this protein?
Probable inactive receptor kinase At5g16590.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: OST3A_ARATH
Sequence: MVIQTNLSYRFFILIVFLFTLANPKSDSDLKNELVSLRSTAESGVISFNNDDVSKFITSVSTPRPYSLIIFFDAVHLHGNSQLRLPEFRREFRLVSATFITNNNNESNGTKLFFCEIESTHSEASFRRFAVESLPHISLVSPTTENLTESDQMDGGDFTGLAESMAEFVERQTKLTVCSIQRPPLISKTQIGIIVAIIIISTPILIKKILKGETLLHDHRIWLVGAVFVYFFSVSGTMHNIIREMPMYIKDYEDSSKFVFFIEESEMQLGAEGFFVGFLYTVVGLLLAFVTNVVVRVKKLDEQRMAMLLALSISFWAVRKVVYLDNWKTGYEIYPYWPSSWRG
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3A.
What is the protein family that this protein belongs to?
Belongs to the OST3/OST6 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL2_LISIN
Sequence: MAIKKYKPTTNGRRHMTSSDFAEITTSTPEKSLLRPLKKKAGRNNQGKLTVRHHGGGHKRQYRVIDFKRNKDGIPGRVATIEYDPNRSANIALINYADGEKRYIIAAKGLEVGQTIYSGAEADIKVGNALELKDIPVGTVIHNIEMKPGKGGQLVRSAGTSAQVLGKEGKYVLIRLNSGEVRMILATCRATIGQVGNEQHELINIGKAGRSRWMGKRPTVRGSVMNPNDHPHGGGEGKAPIGRKSPMSPWGKPTLGYKTRKKNNNSDKFIVRRRKKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: VIF_HV1MP
Sequence: MENRWQVMIVWQVDRMRIRTWNSLVKHHMYVSRRAKGWFYRHHYESRHPKVSSEVHIPLEDDSKLVIITYWGLHTGERDWHLGHGVSIEWRQKRYRTQVDPDLADQLIHLRYFDCFSESAIRNAILGHRVSPRCNYQAGHNKVGSLQYLALTALITPKKIKPPLPSVRKLVEDRWNNPQKTKGHRGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: IMMM_ECOLX
Sequence: MLTLYGYIRNVFLYRMNDRSCGDFMKVISMKFIFILTIIALAAVFFWSEDKGPACYQVSDEQARTFVKNDYLQRMKRWDNDVQLLGTEIPKITWEKIERSLTDVEDEKTLLVPFKAEGPDGKRMYYGMYHCEEGYVEYAND
What is the function of this protein?
This protein is able to protect a cell, which harbors the plasmid ColBM-Cl139 encoding colicin M, against colicin M.
What are the official names of this protein?
Colicin-M immunity protein, Microcin-M immunity protein.
Protein: PGK_BIFLS
Sequence: MKTLKDLGDLKGKRVLVRADFNVPLDGTTITDDGRIKAALPTIKTLREEGAKVILMAHLGRPKGKVVPELSLAPVAARLGELLGTNVPLAKDTYGEDAQAKVAAMNDGDVVLLENVRFNPEETSKDADERAAYAKKIAALGEAFVSDGFGVVHRAQGSNYDVAADLPAAAGLLVEKEVKALSKATENPERPFTVVLGGSKVSDKLGVIENLLDKANRLVIGGGMVFTFLKAKGYEVGTSLLEEDQLEKVKGYIETAEKNGVELVLPTDVVVNAGFPAGDTPVAPEVVAADAIPADKMGLDIGPESQKLFHDKIVDSKTVVWNGPMGVFEVPEFAAGTKAVAQGLVDATAAGAFTIVGGGDSASAVRNLGFPEDGFSHISTGGGASLEFLEGKELPGLKVLE
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_CLOBL
Sequence: MNIKPEEITSIIRQQIENFNTNIETIDSGTIIQIGDGIARVYGLEDCMEGELIEFPNDVYGMALNLEQDNVGCVLLGAEEGIKEGNVVKRTKKVVEVPVGEALVGRVVNSLGMPIDGKGPVLTTENRDVEVPAPGVIDRQSVKEPLQTGIKAIDSMIPIGKGQRELIIGDRQTGKTAIAMDTILNQKGKDVICIYVAIGQKQSTVAHIVNDLTKMGAMDYTIVVSSTASDSAPLQYLAPYAGCSMGEYFMHKGKDVLIVYDDLSKHAVAYRTMSLLLRRPPGREAYPGDVFYLHSRLLERSARLSEKLGGGSLTALPIVETLAGDVTAYIPTNVISITDGQIFLESELFNAGQRPAVNAGISVSRVGGNAQIKAMKQVAGTLRLELAQYRELAAFSQFGSDLDKESVKRLEKGKRLVEILKQPQYGPMPVEKEIIILYAAVNNHLIDIPVNKIKEFEKELFNYIDTHYRDIGKDILEHKQLTDELKSKLDKAINDFKNVFLSEI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: METK_TREDE
Sequence: MKNDINYFTSESVSEGHPDKLCDQISDAVLDACLRDDPESHVACETFASTALVLVGGEITTNTYVDIQEIARSIAEEIGYTNTDFGLDCHSMAVMNMIHSQSPDISQGVDGTGLDEYKGQQGAGDQGMMFGFACKETPELMPAPIMFSHSVLRYAAKLRKEKVIPWLRPDSKTQITVKYEGFKPIKIDTVVLSHQHYPDVQYDELKDTLINRVIKPVLGPTGLLADDTKYFINPTGRFVIGGPFGDTGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMARYIAKNVVAADLARRCEVQLAYAIGVPFPVAVRVDTFGTGEVPEEKIEKAIKEVFDMSPAGIIKTLDLKRPIYKETAAYGHFGRPEFSWEKTDKTEALKKAIK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRPE_MYCPA
Sequence: MSGGLTPDQAIDAIRGTGGAQPGCRALHAKGTLYRGTFTATRDAVMLSAAPHLDGSTVPALIRFSNGSGNPKQRDGAPGVRGMAVKFTLPDGSTTDVSAQTARLLVSSTPEGFIDLLKAMRPGLTTPLRLATHLLTHPRLLGALPLLREANRIPASYATTEYHGLHAFRWIAADGSARFVRYHLVPTAAEEYLSASDARGKDPDFLTDELAARLQDGPVRFDFRVQIAGPTDSTVDPSSAWQSTQIVTVGTVTITGPDTEREHGGDIVVFDPMRVTDGIEPSDDPVLRFRTLVYSASVKLRTGVDRGAQAPPV
What is the function of this protein?
Has an organic peroxide-dependent peroxidase activity.  Exhibits strong peroxidase activity using organic hydroperoxides as cosubstrates, weak peroxidase activity using hydrogen peroxide and negligible catalase activity.  May have a role in elimination of reactive oxygen species, in particular by deactivating hydroperoxides.
What are the official names of this protein?
Catalase-related peroxidase.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
Protein: O163_CONST
Sequence: MKLTCVVIVAVLLLTACQLITADDSRGTQEHRALRSDTKLSMLTLRCESYGKPCGIYNDCCNACDPAKKTCT
What are the official names of this protein?
Conotoxin 3, S6.9.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CRCB_CHLCH
Sequence: MVDKAAHILLVGVGGFLGSVARYLVALWMAPITAVFPFATLTVNLLGSFLIGFISELALSTSLISPSTRIFLVTGFCGGFTTFSSYMIEHSALLRDGEHLYAALYLFGSLIGGFIALYLGIISARWMAG
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: O16E_CONCT
Sequence: VVIVAVLLLTACQLITANDSRGTQKHRALRSDTKLSMSTRCKGKGASCRRTSYDCCTGSCRSGRCG
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels.  This toxin blocks N-type calcium channels (Cav2. 2/CACNA1B).  It shows a higher potency when Cav2. 2/CACNA1B is only expressed with the ancillary subunit CACNB3 (IC(50)=0. 12 nM) than on Cav2. 2/CACNA1B expressed with the ancillary subunits CACNA2D1 and CACNB3 (IC(50)=2. 6 nM).  The Cav2. 2/CACNA1B block by this toxin is voltage-independent, whereas the recovery from toxin block is voltage-dependent (PubMed:19892914).  There is a low recovery at physiological membrane potential and a high recovery with hyperpolarized potential (PubMed:19892914).  This indicates that the toxin has a higher affinity for Cav2. 2/CACNA1B in the inactivated state (PubMed:19892914).  It is noteworthy that ancillary subunits beta modulate recovery from this toxin block (PubMed:19892914).  Cav2. 2/CACNA1B expressed with the ancillary subunit CACNB2a (isoform 2a) almost recover completely from this toxin block, whereas Cav2. 2/CACNA1B expressed with CACNB3 exhibits relatively weak recovery (PubMed:19892914).  Inhibition by this toxin of excitatory synaptic transmission is reversible (PubMed:19892914).  In vivo, when tested on rat model of persistent pain, this toxin blocks chronic pain behavior (PubMed:19892914).
What are the official names of this protein?
Omega conotoxin-CVIE, Omega conotoxin-CVIE-2.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: XKS1_SCHPO
Sequence: MFLGLDLSTQQLKGVVIDESLNVHQEVAVDFDRDLSDYNTIKGVYRNGYEVFAPVCMWLDAIDLLFERLKASVDVSKIQAISGAGQQHASVFLLKGSKKALNSLDAKSSLKQQLESLIHPTSPNWQDASTTKECEELESCIGGAKALADLTGSKAHLRFTGPQIKRFRRLHPETYENTERIALVSNFLASVLLQTEAPLDISDVCGMNLWDIQNEKFDIRLLEEVAGNSKGPDLANKLGTVEINGAKHLGPIGKYFVKKYGFSPNCQIIPLTGDNPATILSLPLRPGKDVLLSLGTSTTALMATQNYVCSPEYHMFAHPVTQNHYMVMLCYKNGSLAREQVRNTINEKYNVSDNTSWDRFNESILNPNIKGAGEKKQLGLFYPQREILPAVGPGTWRFAIQGTELYQVDKDEESWDYPDEDASAIVESQNLDIRMRITPLLTGIPQPDRVYVVGGASRNEAIVFKISQVLGCDVYRLKHGGSNACAVGGAIKAAYAMNGKGFTFEEYVNKSWDESKKIELIMNKPSAQTYEEYGKLLPFLKKAEDIAIQQSDIRH
What are the official names of this protein?
Xylulose kinase, Xylulokinase.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RLMN_HELMI
Sequence: MNVKEPAEEAAIQLRTERQRIEPEGEEQSEQPTDLRGLFPEEIAALLTPWGQPTFRGKQIFKWLQNRAVREVAEMTDLPQALRVRLGEAGWLKPLAPERHRVARDGTEKYLWRLADGELIESVLMPYRRAQTRDRVTVCLSTQAGCPLSCRFCATGRQGFRRNLTAAEIVGQVLDITHEKRKDDPDFKVTNLVFMGMGEPFLNYDNVRRAIGLFTHPEGQAIGQRRITVSTAGIVPGIDRFADEDWEVNLALSLHAADDKQRSEWMPVNDRFPLAQVLEACRRYWEKTRRRLSVEYALMAGVNDRLEDARRLASLFKGWPIHLNLIPVNAVAGIGVRRPEREPTERFLAELRRWGVDAVIREERGQDIEAACGQLRGAAKGEEEA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_ACIF2
Sequence: MRASQIFIPTLKETPAEAELVSHQLLLRGGFIRRLASGLYTWMPLGLRVLRKVERVVREEMDRSGAQELLMPVVQPAELWQESGRWEQYGPELLRLRDRHDREFCLGPTHEEVISDLARREIHSYRQLPVNFYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFHMDHSSLEITYQAMYEAYQRVFTRLGLSFRAVEADNGAIGGKRSHEFHVLADSGEDAIVSCHHCDYAANMEKAASRPDLAETEIPLAAERVRTPGIRTVAEQAEHLGIPTAKIVKTVLVVADGKTVMLLLRGDDELNLVKAGHALNAQDVQMARPEEAISATGAPLGFIGPKEPLLSIPILADHRALGVANFSTGANAADLHWINLNWDRDLPRPAAADLRNVRAGDACPHCAEGTLSIRRGIEVGHVFQLGERYSESMGITVLDETGRDATVTMGCYGIGVSRVVAAAVEQHFDDRGIIWPVALAPFEVGIVAINARKSPDVAAAAQALHDRLEAEGYSVLLDDRDERPGVQFATMDLVGLPHRIVVSDTVLAQGVWEYRARRTTENVLLDETQLMERLRKEHARG
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_MALP2
Sequence: MLLVAFKDPRITRIAKVNLIGGQAKPGPQLASIGINMGEFTKQFNDQTKDKNGEVIPCIITAFKDKSFTFEIKTTPVTMLLKKAANIKVGAKNSKTETVATISREKALEIAKTKLVDTNANDEEAVLRMVAGSAKQMGIKIEGVDPVVHKDGKKK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: Y2236_BACTN
Sequence: MAEHNELGKAGENAAVAYLEEHGYLIRHRNWRKGHFELDIVAAKENELVIVEVKTRSNTLFAQPEEAVDLPKIKRTVRAADAYMKLFQIDVPVRFDIITVIGENGNFRIDHIKEAFYPPLF
What are the official names of this protein?
UPF0102 protein BT_2236.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: SPX_STRP6
Sequence: MVTLFLSPSCTSCRKARAWLVKHEVDFQEHNIITSPLSRDELMSILSFTENGTEDIISTRSKVFQKLDIDVEELSISGLIDLIAKNPSLLRRPIIMDQKRMQIGFNEDEIRAFLSRDYRKQELRQATIKAEIEG
What is the function of this protein?
Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes.  Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP).  This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
What are the official names of this protein?
Global transcriptional regulator Spx.
What is the protein family that this protein belongs to?
Belongs to the ArsC family. Spx subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADA_BOVIN
Sequence: MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPEFLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAIDLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGYHTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIFKSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAEQCL
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (By similarity).  Plays an important role in purine metabolism and in adenosine homeostasis (By similarity).  Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity).  Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity).  Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity).  Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (PubMed:23240012).  Enhances CD4+ T-cell differentiation and proliferation (By similarity).  Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity).  Stimulates plasminogen activation (By similarity).  Plays a role in male fertility (By similarity).  Plays a protective role in early postimplantation embryonic development (By similarity).
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen. Cytoplasm. Lysosome. Note=Colocalized with DPP4 at the cell surface.