PharMolix/UniProtQA huggingface dataset:
Protein: CD44_PAPHA
Sequence: MDKFWWRAAWGLCLVQLSLAQIDLNITCRFEGIYHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPGEDCTSVTDLPNAFDGPITITIVNRDGTRYVKKGEYRTNPEDINPSSPTDDDVSSGSSSERSSTLGGYIFYNHFSTSPPIPDEDGPWITDSTDRTPATRDQGAFDPSGGSHTTHGSESAGHSHGSREGGANTTSGPLRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINNGNGAVEDRKSSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV
What is the function of this protein?
Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment.  Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection.  Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases.  Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.
What are the official names of this protein?
CD44 antigen, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli.
Protein: YMY9_YEAST
Sequence: MPIKETDKEVVLTHPADETTSVHILKYGATVYSWKLKSEEQLWLSTAAKLDGSKPVRGGIPLVFPVFGKNSTDEHLSKLPQHGLARNSTWEFLGQTKENPPTVQFGLKPEIANPELTKLWPMDYLLILTVELGSDYLKTAIEVENTSSSKELKFNWLFHTYFRIEDIEGTMVSNLAGMKLYDQLLKESYVDKHPVVTFNQETDVIYQNVSAERAIQIVDKGVQIHTLKRYNLPDTVVWNPWIEKSQGMADFEPKTGYQQMICIEPGHVHDFISLAPGKKWNAYQLLCKEELKYQAIQ
What is the function of this protein?
Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).
What are the official names of this protein?
Glucose-6-phosphate 1-epimerase, D-hexose-6-phosphate mutarotase.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate 1-epimerase family.
Protein: ADEC1_LATSS
Sequence: MIMSDRLTAFKELIQAGGAKRPADLIIKNGQLVNVMTAEIYPAEVAIYQGKIVAVDPDVSAYQGTETRVIDAKQQYIVPGLIDGHIHVECSKLSMTSFAEAVVPHGTTSIISGLDEYISVIGVDGLSEIFKEVDQLPMRVFWGAPFKTPYTIPASTIADNIDSTVQAQLQKRSDVYGVWETVREAVETLDEDTLKTLLNAQDNHVPVWGCAPMATGTKLNEYLMSGVRVDHESYDHQELLEKVRKGINVVIRESSVTHFLAENIRAITETNGQIARHVSFCTDDVNAMDIVNKGHLDHLVRLAIAAGVAPMTAIQMATINSAEAYRIDDQVGLIAPGRNADILLVSDLEAFEIKRVLAKGQPVATDGHINQSIERPVRPASLANTIIREAVQASDFEYHVAADASQVTVQTIASEGPFVRHAKTKTLTVEDGIVQIDPAKDVALISVLERFGKNGNQSLGFTSGWTLKKGAMASTAAPDDNNIIVMGVNPDDMALAVNTLIERDGGQVVVADGQILSFLPLPIAGIVSDVTPAELAVQEEGILKASQAIGSEVVDPMFYMTFLPITAIPDLAITDLGNVDCNELRLFDPILTIQ
What are the official names of this protein?
Adenine deaminase 1, Adenase 1, Adenine aminase 1.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: NAR1_EMENI
Sequence: MSAILSADDLNDFISPGVACIKPVESLPQKQSNENPYEVTTEDKVQPENPPPAQISLTDCLACSGCVTSAEAVLISLQSHNEVLNTLDAQPEIRLVSGENGTVIEDSGRTRDEGRIFVASVSPQVRASLAATYGVSEKEANHIIHQFLSGPNGLRAGGKHGSGFSWVVDTNSLREAVLVLTADEVSESLTGSSAPKRPILSSACPGWICYAEKTHPFILPHLSRLKSPQALTGTFLKTVISKKLGVPASRIWHLSIMPCFDKKLEASREELTDAAWNRLSSGEPNTPVRDVDCVITSRELLSLASSRGISLPNLPRKSLPQSLRLPFPDPALNVFLFSEKSFSRQTSASGTSGGYLHNVLLSFQARNPGSEIVTQRGRNADVVDYTLMSPEGEPILKAARYYGFRNIQNLVRKLKPARVSRLPGAKVATGQTAGGRRQPISRNGASAGSSMDYAYVEVMACPGGCTNGGGQIRIGDAREFNAQHDASVTSETSKPLPHEQRSWLARVDEAYYSADSDMDDAVEDVRTVSVTDNEDRVHKTLQHWSAITDIPLEKLAYTTYREVESDVGKPSAPNDTSRVVELAGKIGGGW
What is the function of this protein?
Component of the cytosolic Fe/S protein assembly machinery.  Required for maturation of extramitochondrial Fe/S proteins.  May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor nar1, Nuclear architecture-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the NARF family.
Protein: CYSD_MAGMM
Sequence: MTMKTHLQRLEAESIHIMREVVAQFRKPVMLYSIGKDSSVMLHLALKAFYPGKPPFPLLHVDTTWKFREMIVFRDQRVKALGLDLRVHINQEGIAQGITPFNQSASIYTDIMKTQSLKQALEQGGFDAAFGGARRDEEKSRAKERIFSFRTPNHRWDPKNQRPELWNLYNGRIAPGESIRVFPLSNWTELDIWQYIHQEQIPVVPLYFAQPRPVVVRHGALIMVDDGRMPLLPGEEPSLRSVRFRTLGCYPLTGAVESTTTDVAGIIGEMLVAHRSEREGRVIDHDGGASMEEKKQEGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: 5053R_ASFK5
Sequence: MSSSLQELCRKNLPDDILPEFFDDYVLQLLGLHWQDHGSLQRTGKNQVLVQQEPIHINEALKVAASEGNFEIVELLLSWKADPRYAVVGALESKYYDLVYKYYNLIEDRHDMLPLIQNSETFERCHELNNCSLKCLFKHAVIYDKLPILQKYADYLDGWPYCNQMLFELACKKQKYNMVVWIEGVLGVGNFTILFTIAIIKRDLQLYSLGYSIILERMYSCGYDPTFLLNHYLRVVSTKGLLPFVLKTIEYGGSKEIAITLAKKYQHETILRYFETRKSQEC
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 505-3R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 505 family.
Protein: NDHK_CHAGL
Sequence: MVLNANTQFQNSFNEDLFDSIKNPVKTSSDKEELSNSIILTTLNDFSNWARLSSLWPLLYGTSCCFIEFAALIGSRFDFDRYGLVPRSSPRQADLIITAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDIYLPGCPPKPEAIIDAVIKLRKKVGQETYFERAKIQSFHRYFTISHRLKPTYSVEEQLKAKELISNRQENLTISKKKIKESEEIFLQF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: PG027_MONPZ
Sequence: MGIQHEFDIIINGDIALRNLQLHRGDNYGCKLKIISNDYKKLKLRFVIRPDWSEIDEVKGLTVFANNYAVKVNKVDYTLYYVIYEAVIHLYNKKTEILIYSDDENELFKHYYPYISLNMISKKYKIKEENYSSPYIEHPLIPYRDYESMD
What is the function of this protein?
Plays a role for multiplication of the virus in different cell types.
What are the official names of this protein?
Interferon antagonist OPG027, Host range protein 2.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG027 family.
Protein: YBEY_AQUAE
Sequence: MSSTKRQKNRVLVKLKKRKVRKDKIEKWAELALSALGLNNVELSVYITDDQEIRELNKTYRKKDKPTDVLSFPMGEEFGGYKILGDVVISQDTAERQARELGHSLEEEVKRLIVHGIVHLLGYDHEKGGEEEKKFRELENYVLSKLSKAL
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXC_PSEE4
Sequence: MIRQRTLKNTIRATGVGLHSGEKVYLTLKPAPVDTGIVFRRADLSPVVEIPARAANVGETTMSTTLVNGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLEEQDAPKKFIRILREVTVEDGDKRATFLPFDGFKVSFEIDFDHPVLKGQTQSASVDFSSTSFVKEVSRARTFGFMRDIEYLRKHNLALGGSVENAIVVDETGVLNEDGLRSEDEFVKHKILDAIGDLYLLGNSLIGEFKGYKSGHSLNNQLLRKLIAETDAWEVVFFEDASTAPISYMRPVAAV
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: PSTK_METKA
Sequence: MRLLILTGPPGSGKTCFARELARELRQEGWRVAHVEADALRGFLWDEFDPKLEQVARELFLKSVETCLDAELDLVIADDTNYYSSMRRELALLALERKVPWGIVYLRTGLDTCLRRNRERGEPIPEEVVRRIYDRFEPPEPDRWWERATLVLDDSRVSEEVLEFVESGLRVEKPKKRRRRTDPSSVNEVDVRTRQVMGELMRRLSETGAATQELGRKLSELRREIVSSVEDPEKAVREFRRRAEEVIRECLHGDG
What is the function of this protein?
Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) kinase, O-phosphoseryl-tRNA(Sec) kinase, PSTK.
What is the protein family that this protein belongs to?
Belongs to the L-seryl-tRNA(Sec) kinase family.
Protein: C71AC_ARATH
Sequence: MEMILMVSLCLTTLITLFLLKQFLKRTANKVNLPPSPWRLPLIGNLHQLSLHPHRSLHSLSLRYGPLMLLHFGRVPILVVSSGEAAQEVLKTHDLKFANRPRSKAVHGLMNGGRDVVFGPYGEYWRQMKSVCILNLLTNKMVASFEKIREEELNEMIKKLEKASSSSSSENLSELFVTLPSDVTSRIALGRKHSEDETARDLKKRVRQIMELLGEFPIGDYVPALAWIDRINGFNARIKEVSQGFSDLMDKVVQEHLEAGNHKEDFVDILLSIESEKSIGFQAQRDDIKFMILDMFIGGTSTSSTLLEWIMTELIRNPNVMKKLQDEIRSTIRPHGSYIKEKDVENMKYLKAVIKEVFRVHPPLPLILPRLLSEDVKVKGYNIAAGTEVIINAWAIQRDPAIWGPDAEEFKPERHLDSTLDYHGKDLNFIPFGSGRRICPGINLALGLVEVTVANLVGRFDWRAEAGPNGDQPDLTEAFGLDVCRKFPLIAFPSSVI
What is the function of this protein?
Converts indole-3-acetaldoxime to indole cyanohydrin.  Involved in the biosynthetic pathway to 4-hydroxyindole-3-carbonyl nitrile (4-OH-ICN), a cyanogenic metabolite required for inducible pathogen defense.
What are the official names of this protein?
Cytochrome P450 71A12.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MD13L_DANRE
Sequence: MSSCFVPNGASLEDCHSNLFCLADLTGIKWKCFVWQGPTSSPILFPVTEEDPILCSFSRCLKADVLSVWRRHQTPGRRELWIFWWGDDPNFAELVHHDLSCNEDGSWESGLTYECRTLLFKAIHNLLERCLMNRSFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFVHGDSNVCTSVEINQHQPVYLLSEEHLTLAQQSSSSVQVILSPYGLSGTLTGQSFKLSDPPTQKLIEEWKQFYPIGPNTKEVTDDKMDDLDWEDDSLAAVEVVVAGVRMVYPASLVLVAQSDIPLVATVSSSSSSGSYAGAPHNQLVHGDTGISSVTLTPPTSPEEAQAVSQPAQKWVKLSAMSGVFSVDSSSHHGGKIPRRLASQMVERVWQECNINRAQNKRKFSTMSNGVCEEETDKASVWDFVESSQRSQCSCSRLKNQKQRACSTPGHPPSAGQPPQPSTKHKMAEKLEKGDKQQKRPLTPFHHRSSLCEEQPSLEQGESVHRLCLQGHEDSRYPSLHHADVTSSKTPMLHSSADEMAGSPQPPPLSPHPCERMEEPADGMKSSSSPLHQHFYPPSSEPCLEPQKPPDESTLDPLPLPCPPPYPETLEATIYVGSAINPNEDTTHNPWKYFRVPGGRNSDFHTPHLPVVAHFEDGNRTGGQDGIVSITEMMSSSKRPLKVSEELVKMYEHKKNQYLSSAVCDEDPEQESDPYAFEEGDEEFNFSDKDKKSGPEREAGKKAKREDGSSSSDDAQGSGGSKPLPTTSLIHETDLVVSINDLDNLFNSDEDDLTQPGSRRAAGGAEEKFGGKEPKPAAPDPLPCCADLHQMFPTPPSLDQGYSPINMGNTESAAGLSLLDGAMSGNFKMEVEEGFCSPKPSEIKDFSYVFKPESCQALIGCSLYAPLKTLPSQCLLPVKLPEECVYRPSWTVGKLGMLQPMAAMTFLNKDSNIPSVGSVVEQEQSCTPQTHNTFMSNSAPPSNSGAGILPSPATPRISAPTPRTPRTPRTPRGPASVQGSLKYENSDLNSPASTPSTCRPLSSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCICVCNMNITGADVGIYISDPNMDSQYSSMDPCSCGFSAVMNRRYGNGAGLFLEDELDIMGRGSDAAREIEKHFEAVRAASLKRGTVLEEQVPDDLMLLLQDLCTNPFSPIIRPDLLGTVIKSPIRLEERDYYSDCYMALEHGRQFMDNMSGGKVDETLVKSSSLHHWAKRNAFDMSMLFSQDVLRMLLSLQPVLQDTIQKKRSVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTLLVGYEYDYVVLSPFALPYWEKLLLDPYSSQRDVGYMVVCPDNEALLNGAKTFFRDLTAVYESCRLGQHRPIAKSHADGIVTVSDAGSKALTDQTLIDWLPKTINSSSSSEALNKLKLYAHVCRHDLASCLASQSLDGSLLTQRNPASSSQTSSSSSPVTTAQNVTPTTNSNSNTNTNTTPTSTSTSSSSSSCPQGVGNMPSSKPNTIPPFGAQGLQSSQQSGGQSAGTLGDATSATSQPQVPSEPAESTMEREKVGVPTDGDSHAVTYPPAIVIYIVNPFSYEENCQGSSSSVWTIALLRCYLEMLQLLPPHIRNAVYVQIIPSQYLLQPVWSEERHIYAQHLKSLAFSVYTQCRRRLPTSTNVKTLTGFGPGLAIDTALQSKERPQCLHLYAPPFVLAPVKDKQTELGETFGEAAQKYNVLFVAYCLSHDQRWLLASCTDQYGELLETCVISIDVPNRARRKKGSARRQGLQKLWEWCLDLVQMTSLPWRIVIGRLGRIGHGELRDWSILLSRRNLQSLGRRLKEMCRMCGISAADSPSILSTCLVAMEPQASFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSAGLQAFSDVTDGMGGMDGILDLFAENDLVDPDLINIIPNSPTTSPVHSPGSHYHHGGDGSKGQGTDRMESHDESPNILQQPMALGYFVSTAKAGPLPDWFWSSCPQAKNQCPLFLKASLHLNVSSVQSDELLHSKHSHPLDSSHTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLNQMYNFIMNML
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 13-like, Thyroid hormone receptor-associated protein complex 240 kDa component-like protein.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 13 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ALFL5_ORYSJ
Sequence: MDGGSGGPYTSRTAEEVFRDFRGRRAGMIKALTTDVEKFYQLCDPEKENLCLYGYPNETWEVTLPAEEVPPEIPEPALGINFARDGMNEKDWLALVAVHSDSWLLAVAFYFAARFGFDKEARRRLFNMINNLPTIFEVVTGAAKKQTKEKAPNSTNKPNKPSSKMQPRPESHSKAPKPPAPPKDDDESGDEYADEEEEERDNTLCGSCGTNDGKDEFWICCDSCERWYHGKCVKITPARAEHIKHYKCPDCGNKRARA
What is the function of this protein?
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
What are the official names of this protein?
PHD finger protein ALFIN-LIKE 5.
What is the protein family that this protein belongs to?
Belongs to the Alfin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVC_PSEPW
Sequence: MTLILGIDPGSRITGYGVVRQTARGCEYVASGCIRTGSGELHERLQIVFRGVSEIIAQHGPVTMGIERVFMARNPDSALKLGQARGAAIVAAAEAGLEIAEYSATQVKQAVAGTGGANKEQVMLMVMHLLKLTQKPQIDASDALAIALCHAHTRSSLVPHGLATARRRGGRLRL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: PSTB_MYCCT
Sequence: MNNEQLITNVKPKKEPLKTAIEIKDFNFFYNKGKTQSLFNINMEIKEKSITTFIGPSGCGKTTLLKSINRLNDLIDGVKMSGAIKIFDKDIFASDIDITKLRTEVGMVFQKPNPFPISIYDNVVYGLRSLGIKDKAILDQICEESLIKAALWDEVKDILNSPALGLSGGQQQRLCIARAIAMKPKILLMDEPTSALDPIATLKVEELVLDLKKDYTIVMVTHSLQQATRISDYTAYFLKGELIEFNKTKKIFTNPKDRRTENYISGRYE
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HRCA_ACHLI
Sequence: MISSRQKLILKAIIDMYSEKGEPVGSKALMALPYLNYSSATLRYDMAVLEELGFLEKMHTSSGRVPSERGYRYYIEHLVTRDNDVTEVFPLIDEVFSKKALGREHTIKEALKLLTDLTSYTAVAVGPDILQSHIKRIEMVPLGLKDAVMLIVTDTGHVQHQQIHISDDMRMDDIKEVIHTLDDLLKNRTLEDALKVLKEEYAISELNQFMSYQSQIIDSFIEAFSKFASDSFYLSGMTNAFEQPEFNDVSHMKRFIDMMDRREIVKLIGTAEGISVRFGSDMEIKPLNQMTIISIPYQIDSKQKGTIALVGPSRMSYQKVIPLLEYIAANLAKLYKDNNKET
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: ANDR_MACMU
Sequence: MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLQQQQQQQQETSPRQQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSAPECHPERGCVPEPGAAVAAGKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLEGTSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPVLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGAGEAGAVAPYGYTRPPQGLAGQEGDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETAQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
What is the function of this protein?
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.  Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation.  Transcription activation is also down-regulated by NR0B2.  Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
What are the official names of this protein?
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Detected at the promoter of target genes. Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.
Protein: XCP2_ARATH
Sequence: MALSSPSRILCFALALSAASLSLSFASSHDYSIVGYSPEDLESHDKLIELFENWISNFEKAYETVEEKFLRFEVFKDNLKHIDETNKKGKSYWLGLNEFADLSHEEFKKMYLGLKTDIVRRDEERSYAEFAYRDVEAVPKSVDWRKKGAVAEVKNQGSCGSCWAFSTVAAVEGINKIVTGNLTTLSEQELIDCDTTYNNGCNGGLMDYAFEYIVKNGGLRKEEDYPYSMEEGTCEMQKDESETVTINGHQDVPTNDEKSLLKALAHQPLSVAIDASGREFQFYSGGVFDGRCGVDLDHGVAAVGYGSSKGSDYIIVKNSWGPKWGEKGYIRLKRNTGKPEGLCGINKMASFPTKTK
What is the function of this protein?
Cysteine protease involved in xylem tracheary element (TE) autolysis during xylogenesis in roots.  Participates in micro autolysis within the intact central vacuole before mega autolysis is initiated by tonoplast implosion (PubMed:18573193).  Involved in susceptibility to the bacterial plant pathogen Ralstonia solanacearum (PubMed:24947605).
What are the official names of this protein?
Cysteine protease XCP2, Xylem cysteine peptidase 2, AtXCP2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Vacuole. Cell membrane. Note=Predominantly vacuolar. May be associated to plasma membrane.
Protein: SPI2_RABPU
Sequence: MDIFREIASSMKGENVFISPASISSVLTILYYGANGSTAEQLSKYVEKEENMDKVSAQNISFKSINKVYGRYSAVFKDSFLRKIGDKFQTVDFTDCRTIDAINKCVDIFTEGKINPLLDEQLSPDTCLLAISAVYFKAKWLTPFEKEFTSDYPFYVSPTEMVDVSMMSMYGKAFNHASVKESFGNFSIIELPYVGDTSMMVILPDKIDGLESIEQNLTDTNFKKWCNSLEATFIDVHIPKFKVTGSYNLVDTLVKSGLTEVFGSTGDYSNMCNLDVSVDAMIHKTYIDVNEEYTEAAAATSVLVADCASTVTNEFCADHPFIYVIRHVDGKILFVGRYCSPTTNC
What is the function of this protein?
Viral serpin that inhibits both cysteine and serine proteinases involved in the regulation of host inflammatory and apoptosis processes.  Major anti-apoptotic protein which inhibits both intrinsic and extrinsic pathways and strongly cleaves host CASP1 and CASP8 but is a rather poor inhibitor of host CASP3.  Prevents the proteolytic activity of host interleukin-1-beta converting enzyme (ICE) and ICE-like enzymes.  Can also block apoptosis through host tumor necrosis factor (TNF) receptor (By similarity).  The inhibition of host ICE is an example of a 'cross-class' interaction, in which a serpin inhibits a non-serine proteinase.  Also inhibits granzyme B (By similarity).
What are the official names of this protein?
Serine proteinase inhibitor 2, Serp-2, Serpin-2.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Poxviruses subfamily.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: SECA_GLOC7
Sequence: MLKALFGDPNTRKLNKFQSLVTETNLLEEEIKKLSDEELKRKTDEFREELEKASNDRELEEILDEILPEAFALVREASLRVLGMRHFDVQLMGGIVLHKGQIAEMKTGEGKTLVSTLPAYLNGLTGKGVHIVTVNDYLARRDAEWMGQVHRFLGLSVGLIQSGMSPEDRKKNYACDITYTTNSELGFDYLRDNMATSMAEVVQRPFNFCVIDEVDSILIDEARTPLIISGPIDRPTEKYIQASQIAKQLVKQEVEDGPGDYEVDEKARNILLTDEGYKKAEQLLGVKDLFDQDNPWAHYIFNAIKAKELFTKDVNYIVRGGEVVIVDEFTGRVLAGRRWSDGLHQAIEAKERVEIQQETQTLATITYQNFFLLYPKLSGMTGTAKTEETELEKVYNLQVTIIPTNRPSQRYDLPDAVYKAERGKWMAVAEEVEELHQKGRPILVGTTSVEKSELLSNLLRQKEIPHNLLNARPENVERESEIVAQAGRKGAVTIATNMAGRGTDIILGGNSDYMSRLKIREYLMPKLVKPEEDELAVNVPSLGGKRSRPQGFASDKKVKTWKASPDIFPTELSEETVKALKEAVKIAVDQHGQQSLGELEAEEKIAIASENAPTDDIVIQKLREVYKKIRAEYEIFTSKEHNEVVELGGLHVMGTERHESRRIDNQLRGRAGRQGDPGSTRFFLSLEDNLLKIFGGDRVARLMDALQVEEDMPIESGMLTRSLEGAQKKVETYYYDIRKQVFEYDEVMNNQRKAIYAERRRVLEGLDLKEQVLQYAEKTMDEIVEAYVNPDLPPEEWDLNTLVSKVKEFVYLLQDVAPSDIEDMTFMEMKNFLHEEVRKAYEVKEQEVDRVRPGLMRDAERFFILQQIDTLWREHLQGMESLRESIGLRGYGQKDPLIEYKQEGYEMFLEMMIDIRRNVVYSLFQFKPQGQPQAV
What is the function of this protein?
Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.