PharMolix/UniProtQA huggingface dataset:
Protein: ZAPC_IDILO
Sequence: MESESHWLWLFNTESGKLSVKLSDTDVFDTPYKPSQLVNIHFNEQMMDIEDATTFQIVSETLEAYPADKMPCAPQNAALNATAWCRFGRPQMPQSWHFQKSDISEWPLERRLCELNSGFDQGLFLILDTDDEFATCLLLSEGMQLSAIKSLRQYHVIKVTLNRLLPATVDLALSAQSNWGQQLA
What is the function of this protein?
Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ.  Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
What are the official names of this protein?
Cell division protein ZapC.
What is the protein family that this protein belongs to?
Belongs to the ZapC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WECG_SHIF8
Sequence: MNNNTTAPTYTLRGLQLIGWRDMQHALDYLFADGQLKQGTLVAINAEKMLTIEDNAEVRELINAAEFKYADGISVVRSVRKKYPQAQVSRVAGADLWEELMARAGKEGTPVFLVGGKPEVLAQTEAKLRNQWNVNIVGSQDGYFKPEQRQALFERIHASGAQIVTVAMGSPKQEIFMRDCRLVHPDALYMGVGGTYDVFTGHVKRAPKIWQTLGLEWLYRLLSQPSRIKRQLRLLRYLRWHYTGNL
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: TX90A_CTEON
Sequence: ACLDIGNSCRED
What is the function of this protein?
Neurotoxin.
What are the official names of this protein?
U7-ctenitoxin-Co1a, U7-CNTX-Co1a, Neurotoxin Oc F40-4.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 09 (Tx3-6) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PITX2_HUMAN
Sequence: METNCRKLVSACVQLGVQPAAVECLFSKDSEIKKVEFTDSPESRKEAASSKFFPRQHPGANEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
What is the function of this protein?
Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis.  During embryonic development, exerts a role in the expansion of muscle progenitors.  May play a role in the proper localization of asymmetric organs such as the heart and stomach.  Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity).
What are the official names of this protein?
Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAPAM_HUMAN
Sequence: MANENHGSPREEASLLSHSPGTSNQSQPCSPKPIRLVQDLPEELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAENKPRKRQLSEEQPSGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWGTSPEDKQQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNISEEVEAPEVEPRLVYCYPVRLAVSAPPMPSVEMHMENNVVCIRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFEANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYRQSGRSHSSGSSSSSSSEAKDRDSGREQGPSREPHPT
What is the function of this protein?
Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944).  Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178).
What are the official names of this protein?
mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase, Cap-specific adenosine methyltransferase, CAPAM, hCAPAM, Phosphorylated CTD-interacting factor 1, hPCIF1, Protein phosphatase 1 regulatory subunit 121.
What is the protein family that this protein belongs to?
Belongs to the CAPAM family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HOOK2_HUMAN
Sequence: MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
What is the function of this protein?
Component of the FTS/Hook/FHIP complex (FHF complex).  The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).  Contributes to the establishment and maintenance of centrosome function.  May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.  FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997).
What are the official names of this protein?
Protein Hook homolog 2, h-hook2, hHK2.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Golgi apparatus, trans-Golgi network. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome (PubMed:17540036). Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (PubMed:17540036, PubMed:32073997). Often found in close association with microtubules (PubMed:17540036). Localizes to the manchette in elongating spermatids (By similarity).
Protein: PGK_SALTI
Sequence: MSVIKMTDLDLAGKRVFIRADLNVPVKEGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTEGEYNEEFSLLPVVNYLKDKLSNPVRLVKDYLDGVDVAEGELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHGIGKFADVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHSVGKSLYEADLVDEAKRLLTTCDIPVPTDVRVATEFSETAPATLKSVNDVKEDEQILDIGDASAQQLAEILKNAKTILWNGPVGVFEFPNFRKGTEIVANAIADSEAFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEERAKK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICT1_MOUSE
Sequence: MATAWGLRWGLSRTGTLLLAPPARCARRALHRQVDGTTFQSIYSLDKLYPESKGADTAWKVPEHAKQASSYIPLDRLSISYCRSSGPGGQNVNKVNSKAEVRFHLASADWIEEPVRQKIALTHKNKINKAGELVLTSESSRYQFRNLAECLQKIRDMIAEASQVPKEPSKEDARLQRLRIEKMNRERLRQKRLNSALKTSRRMTMD
What is the function of this protein?
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20869366).  Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation.  May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity).
What are the official names of this protein?
Peptidyl-tRNA hydrolase ICT1, mitochondrial, 39S ribosomal protein L58, mitochondrial, MRP-L58, Immature colon carcinoma transcript 1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CA232_HUMAN
Sequence: MNQAFWKTYKSKVLQTLSGESEEDLAEERENPALVGSETAEPTEETFNPMSQLARRVQGVGVKGWLTMSSLFNKEDEDKLLPSEPCADHPLAARPPSQAAAAAEARGPGFWDAFASRWQQQQAAAASMLRGTEPTPEPDPEPADEAAEEAAERPESQEAEPVAGFKWGFLTHKLAEMRVKAAPKGD
What are the official names of this protein?
Uncharacterized protein C1orf232.
Protein: NU1M_ANOQU
Sequence: MFDKIMPLIGSLLLVICVMVGVAFLTLLERKVLGYIQIRKGPNKVGFNGLLQPFSDAVKLFTKEQTYPLLSNYISYYFSPIFSLFLSLVIWMCIPYLIKLYSFNLGVLFFLCCTSLGVYTVMIAGWSSNSNYALLGGLRAVAQTISYEVSLALILLSFIFLIGNYNFLNFYSYQSYIWFIFFCFPLGLVWLASCLAETNRTPFDFAEGESELVSGFNVEYSSGGFALIFLAEYSSILFMSMLFVVIFLGSDIYSLMFFFKLTFISFVFIWVRGTLPRFRYDKLMYLAWKSFLPLSLNYLFFFVGLKIFFISLLF
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PURO_HALS3
Sequence: MYIGRFVVVGPSVAAYRVSSRSFPNRKLIERPAGLTVVPTADAEETTNPYVSYNCVRTAGGHAVVGNGSHVDPITEKVERGYPPRDALTEALLAMDYEKDDYDTPRIAGVLAPDGTAYVGIVRADAVLVRAVEEPTLVATYEKDAPEAIGFDAATAADAAREAYSAAFEHAVCAAGVSRRGVGDGYDTAVVNDP
What is the function of this protein?
Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.
What are the official names of this protein?
IMP cyclohydrolase, IMP synthase, Inosinicase.
What is the protein family that this protein belongs to?
Belongs to the archaeal IMP cyclohydrolase family.
Protein: CO9_HORSE
Sequence: MSAGRTFAFAICILEVSVLTAGPTPNYAPEPEQQSGTPLPIDCRMSSWSEWSECDPCLRQMFRSRSIEVFGQFNGQRCVDAVGDRRQCVPTEACEEVEDDCGNDFQCGTGRCIKKRLLCNGDNDCGDFSDEDDCENDPRPPCRERVVEESELARTAGYGINILGMDPLSTPFDNEYYNGLCDRVRDGNTLTYYRKPWNLASLAYETKADKNFRIEHYEQQIQAFRSVIEERRSHFNADFTLKFTPTEAKKCKQEPEESCNGTDSSENRIFRFAYSKNETYQLFLSYSSKKEKMFLHVKGVIQLGKFVMRSRDVVLTTTFLDDIKALPTAYEKGEYIAFLETYGTHYSSSGSLGGLYELIYVLDKASMDQKGVELRDIQRCLGFNLDLSLKDKYEVTAKIDKNDCLKRNEKEIVNIMDGSLIDDVISLIRGGTRKYAFELKEKLLKGAKTVNVTDFVNWASSLNDAPVLISQRLSPIYNLIPVKMKDAHQKKQNLERAIEDYINEFSVRKCHPCQNGGTVIQIDGQCLCSCPIAFEGIACETGKKKIS
What is the function of this protein?
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.  C9 is the pore-forming subunit of the MAC.
What are the official names of this protein?
Complement component C9.
What is the protein family that this protein belongs to?
Belongs to the complement C6/C7/C8/C9 family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
Protein: YUZF_BACSU
Sequence: MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLIDVKPDHITIEGARNSVCLIRIQHMISVTPDYSERV
What are the official names of this protein?
Uncharacterized protein YuzF.
Protein: CLU_DROER
Sequence: MALETEAKNSNATATSDATATKASGKAKETNNTAGGKKNLNPIPNSNHQNSNQNLVNGNGTAADGPAAKKKGKKNRNKSPPEPTTEAVLSNGHAEKSTLVDAVEDNADADANANVEKPEDGGAPDAEADGEDIDLDALQDVGITVNISSPGADLLCVQLSSMELVQEIHQLLMDREETCHRTCFSLQLDNATLDNFAELKAISNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKNLDPADAYNGIDCTSLTYLNTITQGDLLDKKKTRPDSVDCTPPEYVTPGVSEPPLLPLHPNVKNAKGPQALKVLTTSAWNPPPGPRKLHGDLMYLYVVTMEEKRFHISACSKGFYINQSTDDTFNPKPDNPSHLSHSLIDLLSHISPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWASPTLEHTVDAIRAEDAFSSKLGYEEHIPGQTRDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDPKMQMFIWNNIFFSLGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDVEGLYTLGTVVIDYRGYRVTAQSIIPGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGKHLKILPHAVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIEHRHKLCCLRQELLEAFIEDRHVSFIRIAAVHLQQLNAKKQSEKAEGNPVPALEGAEAVSKVNGADKTDVKEEKNEENEKAQSTAGDTKTAEAMVNAIREAQSNVATSNEVQAAEVVKRACAAVGSLKEKEFDFRFNPDVFSPGIRHVDGEEGTCSSLAKQKVLVQEAAEFLVLKQIPAFVKEHMTHSSPPIDGQSLTESLHSHGINVRYLGKVIKILNQMPRMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFLNCLLTNGPVNPAVSSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQATGNQNGSSSGSSNGSSVSDWTLMTPRSLWQQIRKEAKVYWDWELDCDSIETAVSKYGILRISLLRAFCLKVGIQVLLREYNFESKHKPTFGDDDIVNVFPVVKHISPRATDAYNFYTTGQAKIQQGMFKEGYELISGALNLLNNVFGALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANGHVGMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKAMPVALSYHLMARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTKDSAECLRLLTQQAVLLQRKMNDIYSSGKLTSDLPPIHITPPSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEKHFKADSPENEVNDAISSIVAAANNNGEAEDAVPKDVEEQKEAGTQLTNGEKAAATEATSS
What is the function of this protein?
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
What are the official names of this protein?
Protein clueless, Clustered mitochondria protein homolog.
What is the protein family that this protein belongs to?
Belongs to the CLU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCS1_NOSP7
Sequence: MTLEDSASKELKWWAIPGQFLRQELLPVLTNLRLAIALLLLIAIFSSTGTVIEQGQSPAFYQANYPEHPALFGFLTWKVIQVVGLDHVYRTWWFLALLILFGTSLTACSFTRQLPALKAAQRWKYYEEPRQFQKLALSAELDNGSLNSLSQLLQKRRYKIFPDREKENILYARKGIVGRIGPIIVHIGIVAILLGGIWGAMTGFMAQEMVASGDTFQVTNIVDAGPLAAQVSKDWSVRVNRFWIDYTPSGGIDQFYSDMSVLNKQGEEVDHKKIFVNEPLRYRGITFYQTDWGIAGVRVQFNNSPIFQLPMALLNTKGQGRIWGTWVPTKPDLSEGVSLLAKDLQGMVLIYDPNGKLVDTVRAGMSTQVNGVKLKILDVIGSTGLQIKADPGIPIVYSGFGLLMLGVVMSYFSHSQIWALQKGDLLYVGGKTNRAQVAFEQEVLEILDRLSSEPKIEEKETAIEV
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsB.
What is the protein family that this protein belongs to?
Belongs to the Ccs1/CcsB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PDX1_PLAF7
Sequence: MENHKDDAVLLKHGWCEMLKGGVIMDVKSVEQAKIAEEAGAIGVMVLENIPSELRNKEGVARSVDPSKVEEIKKCVSINVLAKVRIGHFVEAQILEELKIDMIDESEVLTIADEMHHIDKHKFKTPFVCGCTNLGEALRRISEGASMIRTKGEAGTGNIIEAIKHIRTVNNEIKYLCSLSDSEVYHFAKKINAPIDLVLLTKKLKRLPVVNFAAGGVATPADAAMCMQLGMDGVFVGSGIFESENPRKMAASIVSAVSNFNNPKILLDVSMNLGKAMCGSTRVSDKWKNKNEEHTKFLTPQ
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by Pdx2.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit Pdx1, PLP synthase subunit Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRM2_CALJA
Sequence: MVRYRVRSPSERPHEEYRQLVNWQEQGRNGQEEQGLSAEGGEVYGRTHQGYSSYRRRRCSRRRRYRIHRRRSRSCRRRRRRSCRYRRRPRRGCRSRRRRRCRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine-2, Sperm histone P2, Sperm protamine P2.
What is the protein family that this protein belongs to?
Belongs to the protamine P2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: UP05_PSEMZ
Sequence: RQRRRRIKARRRIKRWRRRRIERRRWIEHATADR
What are the official names of this protein?
Unknown protein 5.
Protein: CIDA_BACCZ
Sequence: MKWWKLSGQILLLFCFAWTGEWIAKQAHLPVPGSIIGIFLLLISLKFNLVKKEWIQDGADFLLKELILFFIPSAVAVIRYKDTLSQYGIDLILIIMISTLCVTLVTGLLTELLLKRKGSVQ
What is the function of this protein?
Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation.  Inhibited by the antiholin-like proteins LrgAB.  In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein.  When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability.  These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential.
What are the official names of this protein?
Holin-like protein CidA.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. CidA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LMRA_LACLM
Sequence: MERGPQMANRIEGKAVDKTSIKHFVKLIRAAKPRYLFFVIGIVAGIIGTLIQLQVPKMVQPLINSFGHGVNGGKVALVIALYIGSAAVSAIAAIVLGIFGESVVKNLRTRVWDKMIHLPVKYFDEVKTGEMSSRLANDTTQVKNLIANSIPQAFTSILLLVGSIIFMLQMQWRLTLAMIIAVPIVMLIMFPIMTFGQKIGWTRQDSLANFQGIASESLSEIRLVKSSNAEKQASKKAENDVNALYKIGVKEAVFDGLMSPVMMLSMMLMIFGLLAYGIYLISTGVMSLGTLLGMMMYLMNLIGVVPTVATFFTELAKASGSTGRLTELLDEEQEVLHQGDSLDLEGKTLSAHHVDFAYDDSEQILHDISFEAQPNSIIAFAGPSGGGKSTIFSLLERFYQPTAGEITIGGQPIDSVSLENWRSQIGFVSQDSAIMAGTIRENLTYGLEGNFTDEDLWQVLDLAFARSFVENMPDQLNTEVGERGVKISGGQRQRLAIARAFLRNPKILMLDEATASLDSESESMVQRALDSLMKGRTTLVIAHRLSTIVDADKIYFIEKGEITGSGKHNELVATHPLYAKYVSEQLTVGQ
What is the function of this protein?
Efflux transporter for a variety of amphiphilic cationic compounds, including antibiotics.
What are the official names of this protein?
Multidrug resistance ABC transporter ATP-binding and permease protein.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Multidrug exporter LmrA (TC 3.A.1.117.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL2_BORBR
Sequence: MALVKVKPTSAGRRGMVKVVSPKLHKGAPHAALLEKKTRGSGRNNNGHITVRHRGGGHKQHYRVVDFRRNKDGIPAKVERLEYDPNRTAHIALLCYADGERRYIIAPRGLEVGATLISGIEAPIRAGNTLPIRNIPVGTTIHCIEMIPGKGAQMARSAGASAVLMAREGTYAQVRLRSGEVRRVHIQCRATIGEVGNEEHSLRQIGKAGAMRWRGVRPTVRGVAMNPIDHPHGGGEGRTGEAREPVSPWGTPAKGFKTRRNKRTNNMIVQRRKRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ANPX_PSEAM
Sequence: MALSLFTVGQLIFLFWTMRITEANPDPAAKAVPAAAAPDTASDAAAAAAATAATAAAAAAATAATAAKAAALTAANAAAAAAATAAAAARG
What is the function of this protein?
Contributes to protect fish blood from freezing at subzero sea water temperatures.  Lowers the blood freezing point.  Binds to nascent ice crystals and prevents further growth (By similarity).
What are the official names of this protein?
Ice-structuring protein 2A7, ISP 2A7, Antifreeze protein IIA7, AFP.
What is the protein family that this protein belongs to?
Belongs to the type-I AFP family.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR9_BACC7
Sequence: MKQRALVSVSDKTGVVEFVKGLLEQGIEVISTGGTKKLLEENGLQVIGISEVTGFPEIMDGRVKTLHPNIHGGLLAVRDNETHVAQMNELGIEPIDFVVVNLYPFKETIAKPDVTFADAIENIDIGGPTMIRSAAKNHKFVSVIVDPVDYDVVLAELEENGEVKEETKRKLAAKVFRHTAAYDALISNYLTEQMGEESPETLTVTFEKKQDLRYGENPHQKATFYKAPFAATSSVAYAEQLHGKELSYNNINDADAALSIVKEFTEPAVVAVKHMNPCGVGVGTDIHEAYTRAYEADPVSIFGGIIAANREIDKSTAEKLHEIFLEIIIAPSFSKEALEVLQSKKNLRLLTVNIEKSTSASKKLTSVQGGLLVQEEDTLSLDESTISIPTKREPSEQEWKDLKLAWKVVKHVKSNAIVLAKDDMTIGVGAGQMNRVGSAKIAITQAGEKAQGSALASDAFFPMPDTLEEAAKAGITAIIQPGGSIRDEDSIKVADTYGIAMVFTGVRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: AROD_METAC
Sequence: MTQIGPFDLEKKAAVVAVILEKPLETSKKAAEKGADILEVRLDLLGIRNPESAAKIIREIKSETGLPVLVTNRSVAEGGKWEGKEVDRTELLVALLSLKDGPDAVDIELSASREDRDKVIKAAKAHGKTVIISSHDFSKTPSPQEMTATLAEMFLAEADIAKIAVMPGSMEDVLNLLKVTLEFKNTGKTVCTIAMGKPGKHTRVVAPLYGSVLTYASIESNAVAAPGQLPVDEVKKIMEMLK
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: DHAG_COMTE
Sequence: MNVQFTVNGRAASIDVPPNTLLVQ
What are the official names of this protein?
Aldehyde dehydrogenase gamma chain, ALDH.
Protein: Y763_THEMA
Sequence: MIITTTEQVPGYRVKEILGVVSGNVVMSKHLGRDIAAAFKTLAGGEIKGYTEMLTEARNIALERMMKEAEKLGADAVIGFRYSSSTIMSGAAEILAYGTAVKLEKI
What are the official names of this protein?
UPF0145 protein TM_0763.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: RUVB_STAA9
Sequence: MNERMVDQSMHSEETDFELSLRPTRLRQYIGQNSIKSNLEVFIKAAKLRHEPLDHVLLFGPPGLGKTTLSNIIANEMEVNIRTVSGPSLERPGDLAAILSGLQPGDVLFIDEIHRLSSVVEEVLYPAMEDFFLDIIIGKGDEARSIRIDLPPFTLVGATTRAGSLTGPLRDRFGVHLRLEYYNESDLKEIIIRTAEVLGTGIDEESAIELAKRSRGTPRVANRLLKRVRDFQQVNEDEQIYIETTKHALGLLQVDQHGLDYIDHKMMNCIIKQYNGGPVGLDTIAVTIGEERITIEDVYEPFLIQKGFLERTPRGRKATPLAYEHFAKSNEERG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.