Protein: TRX_DROME
Sequence: MGRSKFPGKPSKSINRKRISVLQLEDDAANPAEPQQPAPESQQPSGSGSGSSAAREKGNNCDNDEDDNAPGGASISGNTASSSAGSGNSGNGSSSGSSTGSGSSGSGSTNGGSVNGGTHHKSAANLDKEAVTKDQNGDGDKTRGNVSSAPSGKLSAAASGKALSKSSRTFSASTSVTSSGRSSGSSPDGNSGASSDGASSGISCGKSTAKSTEASSGKLAKTTGAGTCSSAKSSKASSGTTSEATTSGLSGACLKALFVATPATSTGLACALVSPGGSSQGGTFPISAALLRARKNSNKKFKNLNLARGEVMLPSTSKLKQLNSPVVDNPSPSPPIASGSTPSVEGGIGVGGVVSPGEDAALKRVLTEMPNEVARDPSPSSCTAAANGAASGKGSASNGPPAMASSGDGSSPKSGADTGPSTSSTTAKQKKTVTFRNVLETSDDKSVVKRFYNPDIRIPIVSIMKKDSLNRPLNYSRGGECIVRPSILSKILNKNSNIDKLNSLKFRSAGASSSSSNQESGSSSNVFGLSRAFGAPMDEDDEGGVTFRRNDSPEDQNNAEDDEMDDDDDDEEAEEDDENEDDNDEAVSEKSAETEKSAGADERDPDEKQLVMDSHFVLPKRSTRSSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNVFGTSSSSAGSTASTFSASTNLKLGKETFFNFGTLKPNSSAAGNFVLRQPRLQFQADNQQATFTAPKACPTSPSAIPKPANSLATSSFGSLASTNSSTVTPTPSACSICSAVVSSKEVTQARKYGVVACDVCRKFFSKMTKKSISANSSTANTSSGSQQYLQCKGNEGSPCSIHSAKSQLKNFKKFYKDRCTACWLKKCMISFQLPAAHRSRLSAILPPGMRGEAAAREEKSAELLSPTGSLRFTSTASSSSPSVVASTSVKWKSSGDSTSALTSIKPNPLAENNVTFGSTPLLRPAILENPLFLKISNAADQKLAAAEAISPSLTKKNSKQEKEKVKESEQSEKLLSPTQAGTKKSGAAEAQVEEVQPQKEEAPQTSTTTQPSASNGASHGVPQAELAGETNATGDTLKRQRIDLKGPRVKHVCRSASIVLGQPLATFGEDQQPEDAADMQQEIAAPVPSAIMEPSPEKPTHIVTDENDNCASCKTSPVGDESKPSKSSGSAQAEVKKATALGKEGTASAAGGSSAKVTTRNAAVASNLIVAASKKQRNGDIATSSSVTQSSNQTQGRKTKEHRQQRTLISIDFWENYDPAEVCQTGFGLIVTETVAQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRPLICVNCLKCKSCSTTKVSKFVGNLPMCTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSKCEGLSDEQYNLLSTLPESIEFICKKCARRNESSKIKAEEWRQAVMEEFKASLYSVLKLLSKSRQACALLKLSPRKKLRCTCGASSNQGKLQPKALQFSSGSDNGLGSDGESQNSDDVYEFKDQQQQQQQRNANMNKPRVKSLPCSCQQHISHSQSFSLVDIKQKIAGNSYVSLAEFNYDMSQVIQQSNCDELDIAYKELLSEQFPWFQNETKACTDALEEDMFESCSGGNYEDLQDTGGVSASVYNEHSTSQAESRSGVLDIPLEEVDDFGSCGIKMRLDTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSIDCAFLTDKSMYCPAHAKNGNALKANGSPSVTYESNFEVSRPVYVELDRKRKKLIEPARVQFHIGSLEVRQLGAIVPRFSDSYEAVVPINFLCSRLYWSSKEPWKIVEYTVRTTIQNSSSTLTALDVGRNYTVDHTNPNSKEVQLGMAQIARWHTSLARSEFLENGGTDWSGEFPNPNSCVPPDENTEEEPQQQADLLPPELKDAIFEDLPHELLDGISMLDIFLYDDKTDLFAISEQSKDGTQAMTSNQAQNQNQQAGGANSVSICDEDTRNSNTSLGNGWPASNPVEDAMLSAARNSSQVQMLKTLAWPKLDGNSAMATAIKRRKLSKNLAEGVFLTLSSQQRNKKEMATVAGVSRRQSISETSVEGVATTSGSVRSKSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYDAFQRHLPSCSPTMSSNETESDVSGQGMTNNATQISAESLNELQKQLLANAGGLNYLQSATSFPQVQSLGSLGQFGLQGLQQLQLQPQSLGSGFFLSQPNPATQANTDDLQIYANSLQSLAANLGGGFTLAQPTVTAPAQPQLIAVSTNPDGTQQFIQIPQTMQATTTPTATYQTLQATNTDKKIMLPLTAAGKPLKTVATKAAQQAAVKQRQLKSGHQVKPIQAKLQPHPQQHQQQQQTQVQQPITVMGQNLLQPQLLFQSSTQTQAPQIILPQAQPQNIISFVTGDGSQGQPLQYISIPTAGEYKPQPQPTATPTFLTTAPGAGATYLQTDASGNLVLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQPGSNQQPLILGGTGGGSSGLEFATTSPQVILATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLSQNASFSATTTQVFQASKIEPIVDLPAGYVVLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNANFQFQSVPTSSGASTSMDYTSPVMVTAKIPPVTQIKRTNAQAKAAGISGVGKVPPQPQVVNKVLPTSIVTQQSQVQVKNSNLKQSQVKGKAASGTGTTCGAPPSIASKPLQKKTNMIRPIHKLEVKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELANRVQHFSTSSSSSSSNCSLPTNVVNPMQQQAPSTTSSSTTRPTNRVLPMQQRQEPAPLSNECPVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPVYEAELKVSSVLESIVPDVTMDAILEEQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLDKHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKILDNLTNDDCADSIATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALETAAVEAAATYINEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQPIQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRRGTGSNLPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN
What is the function of this protein?
Histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) (PubMed:12408863).  H3K4me represents a specific tag for epigenetic transcriptional activation (PubMed:12408863).  Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes (PubMed:2107543, PubMed:7958911).  Acts as an activator of BX-C (PubMed:7924996).  Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo (PubMed:7924996, PubMed:25310983).  Also has auto-methylation activity on Cys-3641 (PubMed:24235145).
What are the official names of this protein?
Histone-lysine N-methyltransferase trithorax, Cysteine methyltransferase KMT2A, Lysine N-methyltransferase 2A.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Binds to 16 discrete sites on larval salivary gland polytene chromosomes.