Protein: INPB_EMENI
Sequence: MPGAIESSPSEWLQLELRRICANVLQLDTKDVDPQRSFLSLGGDSLLAIKILAQCRAQGITINIADIMAATTLESLYSMAQGPAELASSSTSDNASDKDSSLDDSETGALTPTTDAGSSLADTLSPEMKAKLSALSVSQDTAIQAVVPCSAIQDRMLVSQLQNPHLYSCCFVLRLTHSHPGLPVDAKRLGTAWGEVVKRHSSLRTVLVESTQRPGHYNQVILAGIIPAVEHYEGADHLGSVKFNVNNPIVFQPHSIPHRLQLVQVSPSEVYLKFDISHLLIDGQSAEVLLKDLSDAYRDGGLAAAPLSYADYVSSYLLEPAQLNTSRKESGMEMSPLTVPMDRPNEGLFDFQTVSANVPLDSRLVQSVCARYSVTLATVCQLAWGLVLRCYAGTDSVCFSYVNSGRSMSIPGVQEVIGPIVQTSMCSIQLGPADELPKILQRIHRDALQAMSQLSPLEANSTSKSARQLSNTTMSFQRALDDAAAQRAGLLVKIEGKANPTDYDISLGIAAGADGLSVDLDFWGSRLDEESARTMLGAFEAAIRGIIDSPDSTVSNISLLSPGEVSQLAQWNASIPKPERVCVHDKIMEISKLQPGAAAVNSWDGNLTYHDLTVQASTLAHHLRDQLGVGPERFVGICMDKSKWAIVSMLAVLMAGGIVVPLGVSHPRARIRELLNDTAAVALLVDGKHGDRLAGLEVENAAMLTVDQQLLDSLPTIPKPPVSGVTPDNAAWVIYTSGSTGVPKGVVLLHQNISTSVIAHGAVFGVNCVTRTAQFASYTFDVSLSDIVMTLFHGGCVCIFSEESRMNSLTEALQGLAVNYVNLTPTVLGLLNPADLPVIRTVVAGGEAMDPGIIEKWSPHARVFNSVGPSECTIIAVAAGPVTDPAQAANVGYPTGTRLWVALPTDPNQLCPVGVPGELLIEGPMLSRGYLNDPEKTAGAFITNPAFVKHLEAATPAWKVLFQKSERRFYRSGDLVRQKRDGSLVHMGRRDTQVKIRGQRVEIGEIEYWIMQRLKEVRRVAVLVIERGQGKEQKSLVAAVEFKEDYEDVRHSDDDISPVTKIGESTVLPQLLPLTEPLSKALHQLRNDLLEHLPPYMSPTMYAPVSQLPLNLSGKIDRRAVTQFINELDDVQLQQYLAVSGSHQEPSTETEFKLQKLWAKTLGVDVSQISADSHFFHIGGDSVAAMRVVAAARDVELVLRVADLFEYPRLPDLARAVESRVVDEADEEDPAPFSVWRESRGSEPSEEPVELDKIAAMCNLSKEQIEDVLPCTALQEGLIALTAQQPTAYIDRRVFALSQEVDLSQYRAAWQIVIHRTSALRTRIVSGPQTGSLQVVVVPRHIDWNKSSSLDEYLETDRQTGMMMGQPLNRFAFVDQPDGQRFFVWTTHHSTYDGWSRALVLQQVADAYASRDLPPIASFSRFIQYIHSQPQDAAASYWKAQLGGDTSADFPALPIANYRPRPQQRHQHTVNLASSSTKVMLPDLLRGAWALVVHQYVGKTDPVFAIALSGRNAPVRNVPNIAGPTLTTVPVRIFIDPEQLVNEFLQSVRQQAVDMIPYEHTGLQRIKKMVPELAAAVDLKHLFVVQPASDGESKFKIPGVTEHLVAVDEFDSYGLNVECMLSGQSIEVDVRFDEKMLSSSQVIRLMSQFEAVVHQLHLHGEGSLKIKDIDLLSPEDVNQLRQWNALPLAQPLDVCLHDLIAEVARSRPGAAAIEAWDGTLTHAQLQSYASTLAGYLIELGVGPEISVPVCMDKSVWAVVCFLAVLQAGGVVVPLGTGHPIPHIASIIEDTGAKLVLVDAQQFERLLELTPSRGLTLVPIDTQLLNSLPTAAPQTSVTPANAAWIVFTSGSTGKAKGVVLTHSNLSTAIKTHGARFGLGTHTRTIQFAAHTFDAVLQDYFTTLASGGTVCVPSEADRMNDLAGVMRGMNVNFANLTSTVARLLTPDQVPSLKVLILAGEQIQDSVVETWYKHAEVLNVYGPTECSINSTCNGPISDLSNAQSIGFGMGSRTWIADPTDPNRLCPVGTPGELLIEGPGLARGYLGDPAKTEAAIIQNPSFASRFALSDCRVYRTGDLAKQTEDGQILYLGRIDTQIKIRGQRVELGEIEHWIGRHLPHVKHTAVVAISRGEKQMRLAAVIERENGHKPDPVIFTQLKKTLSSLLPSYMVPSLYIPVTEIPLTVSGKLDRRAIKQTVESMPTEELEQYFAGESSGTRVPPSTEMEKALQRIWANSLGIEVDAIGADDNFFQLGGDSVVAMHISASSRQDQSVKGLAVGDIFMHPRLADLAVLLEKRPREGEGGWDEEMRDDESPFALLQEVLDLDLKDI
What is the function of this protein?
Nonribosomal peptide synthase; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor (PubMed:18804170, PubMed:20952652, PubMed:27294372).  In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB (PubMed:27294372).  The 3-hydroxydodecanoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB (PubMed:27294372).  The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino acid, L-Leu (PubMed:27294372).  Reductive releasing of the lipotripeptide by the TE domain of inpA produces (2S)-fellutamide B (PubMed:27294372).  InpF might be involved in the release and transfer of the lipodipeptide from inpB to inpA (PubMed:27294372).  The inp cluster-encoded proteasome subunit inpE confers resistance to internally produced fellutamides (PubMed:27294372).  The MFS efflux transporter inpD may contribute to fellutamide resistance as well (PubMed:27294372).
What are the official names of this protein?
Nonribosomal peptide synthase inpB, Fellutamide B biosynthesis cluster protein B, Inp cluster protein B, Interacting NRPS system protein inpA.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.