PharMolix/UniProtQA huggingface dataset:
Protein: DER_BARQU
Sequence: MSLTIAVVGRPNVGKSTLFNRLVGQKLALVCDKPGVTRDRRIHAAELQDLCFDVIDTAGLEEAGDHTLEGRMCSHTKAAINEADLILFMFDAKSGITPSDLNFASLVRKSGKPIVLVANKSESKAAVGVEYEAWSLGLGEPCPISAEHGLGLSDLRDAIMDAIGKERVFESKNAEKCVSVQSASVGDYVDDLEEKGSVCDESKQPLRIAVAGRPNTGKSTLINRMLGQDRLLTGPEAGLTRDSISVDWEWRGRHIKLFDTAGLRRKSKIQEKLEKLSVADTLRAIRFAEVVVIVFDATAPFEKQDLQIADLVIREGRVPIIAFNKWDLIENNSQVTLANLHEKCAHLLPQVPGLRAVPLSGQYGQGIDNLMENVMMMHRMWNRRISTAKLNRWLETIVAHHPPPAIFGRRLKVKYITQVKTRPPGFVISCSRPKTMPQSYLRYLSNGLRNTFDMPGVPIRISLRASDNPFAARSKKK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: AB41G_ARATH
Sequence: MAQTGEDVDKAKSFQVEFACGNGVDDEEKLRSQWATVERLPTFKRVTTALLHTGDDSSDIIDVTKLEDAERRLLIEKLVKQIEADNLRLLRKIRKRIDEVGIELPTVEVRFNDLSVEAECQVVHGKPIPTLWNTIKGSLSKFVCSKKETKIGILKGVSGIVRPGRMTLLLGPPGCGKTTLLQALSGRLSHSVKVGGKVSYNGCLLSEFIPEKTSSYISQNDLHIPELSVRETLDFSACCQGIGSRMEIMKEISRREKLKEIVPDPDIDAYMKAISVEGLKNSMQTDYILKILGLDICADTRAGDATRPGISGGQKRRLTTGEIVVGPATTLLMDEISNGLDSSTTFQIVSCLQQLAHIAGATILISLLQPAPETFELFDDVILLGEGKIIYHAPRADICKFFEGCGFKCPERKGVADFLQEVMSRKDQEQYWCHRSKPYSYISVDSFIKKFNESNLGFLLKEELSKPFDKSQTRKDSLCFRKYSLSKWEMLKACSRREILLMKRNSFIYLFKSGLLVFNALVTMTVFLQAGATRDARHGNYLMGSMFTALFRLLADGLPELTLTISRLGVFCKQKDLYFYPAWAYAIPSIILRIPLSVLDSFIWTVLTYYVIGYSPEVGRFFRHFIILLTFHLSCISMFRAIASICRTFVACSITGAISVLLLALFGGFVIPKSSMPTWLGWGFWLSPLSYAEIGLTANEFFSPRWRKLTSGNITAGEQVLDVRGLNFGRHSYWTAFGALVGFVLFFNALYTLALTYRNNPQRSRAIVSHGKNSQCSEEDFKPCPEITSRAKTGKVILPFKPLTVTFQNVQYYIETPQGKTRQLLFDITGALKPGVLTSLMGVSGAGKTTLLDVLSGRKTRGIIKGEIRVGGYPKVQETFARVSGYCEQFDIHSPNITVEESLKYSAWLRLPYNIDAKTKNELVKEVLETVELEDIKDSMVGLPGISGLSTEQRKRLTIAVELVSNPSIIFLDEPTTGLDARAAAIVMRAVKNVAETGRTVVCTIHQPSIDIFETFDELILMKDGGQLVYYGPLGKHSSKVIKYFESIPGVPKVQKNCNPATWMLDITCKSAEHRLGMDFAQAYKDSTLYKENKMVVEQLSSASLGSEALSFPSRYSQTGWGQLKACLWKQHCSYWRNPSHNLTRIVFILLNSLLCSLLFWQKAKDINNQQDLFSIFGSMYTIVIFSGINNCATVMNFIATERNVFYRERFARMYSSWAYSFSQVLVEVPYSLLQSLLCTIIVYPMIGYHMSVYKMFWSLYSIFCSLLIFNYCGMLMVALTPNIHMALTLRSTFFSMVNLFAGFVMPKQKIPKWWIWMYYLSPTSWVLEGLLSSQYGDVEKEITVFGEKKSVSAFLEDYFGYKHDSLAVVAFVLIAFPIIVASLFAFFMSKLNFQKK
What is the function of this protein?
May be a general defense protein.
What are the official names of this protein?
ABC transporter G family member 41, ABC transporter ABCG.41, AtABCG41, Pleiotropic drug resistance protein 13.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KCNA6_HUMAN
Sequence: MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV
What is the function of this protein?
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.  Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698).  The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698).  Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity).  Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity).  Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).
What are the official names of this protein?
Potassium voltage-gated channel subfamily A member 6, Voltage-gated potassium channel HBK2, Voltage-gated potassium channel subunit Kv1.6.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GYS1_YEAST
Sequence: MARDLQNHLLFEVATEVTNRVGGIYSVLKSKAPVTVAQYGDNYTLLGPLNKATYESEVEKLDWEDESIFPEELLPIQKTLMSMREKGVNFVYGNWLIEGAPRVILFELDSVRHFLNEWKADLWSLVGIPSPEHDHETNDAILLGYVVVWFLGEVSKLDSSHAIIGHFHEWLAGVALPLCRKKRIDVVTIFTTHATLLGRYLCAAGDVDFYNNLQYFDVDQEAGKRGIYHRYCIERAAAHTADVFTTVSQITALEAEHLLKRKPDGILPNGLNVVKFQAVHEFQNLHALKKDKINDFVRGHFHGCFDFDLDNTVYFFIAGRYEYKNKGADMFIESLARLNYRLKVSGSKKTVVAFLIMPAKTNSFTVEALKSQAIVKSLENTVNEVTASIGKRIFEHTMRYPHNGLESELPTNLDELLKSSEKVLLKKRVLALRRPYGELPPVVTHNMCDDANDPILNQIRHVRLFNDSSDRVKVIFHPEFLNANNPILGLDYDEFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSITTNVSGFGAYMEDLIETDQAKDYGIYIVDRRFKSPDESVEQLADYMEEFVNKTRRQRINQRNRTERLSDLLDWKRMGLEYVKARQLGLRRAYPEQFKQLVGETISDANMNTLAGGKKFKIARPLSVPGSPKVRSNSTVYMTPGDLGTLQDANNADDYFNLSTNGAIDNDDDDNDTSAYYEDN
What is the function of this protein?
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.  Is believed to regulate the synthesis of glycogen.
What are the official names of this protein?
Glycogen [starch] synthase isoform 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 3 family.
Protein: SYE1_SULDN
Sequence: MIVTRFAPSPTGYLHIGGLRTALFSYLWARKNGGKFLLRIEDTDKARNSQEAAEAIVKAFNWLGLEHDGEITYQSQRDDIYAIYVKQLLDEGKAYRCYMSREELDALRETQMANKERTKYDGKYRDFDGTPPDGVDSVIRIKAPLSGEIIVRDGVKGDVVFKAEDILDDFVIARADGSPTYNFVVAIDDHLMGVTEVIRGDDHLSNTPKQIVIYEALGFDVPKFYHVPMIHNSEGKKLSKRDGATDVMAYKEMGYTPAALLNFLVRLGWSNGDQEIFSMDEMRELFDPKNINRSASIYNTEKLDWLNSHYIKNTPNQELAKMLEEYNLTIASHDKKEILLDALKERAKTLKELALLVTEVINPPASYDEKALEKSLKGEAVEVLNNFIAKLSACKELHLPSEYHHVMQEVVDEMGIGFGKIGQPLRVALLGKMSGPGLDSVMAVIGIDETILRVKSALALVK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_PSEP1
Sequence: MTTVQEAVPNLIPTQDATPRPAPKKVEAGVKLRGADKVARIPVKIIPTDELPKKPDWIRVRIPVSPEVDRIKQLLRKHKLHSVCEEASCPNLGECFSGGTATFMIMGDICTRRCPFCDVGHGRPKPLDLDEPKNLAVAIADLRLKYVVITSVDRDDLRDGGAQHFADCIREIRALSPGVQLETLVPDYRGRMDVALEITAQEPPDVFNHNLETVPRLYKAARPGSDYDWSLDLLQKFKQLVPHVPTKSGLMLGLGETDEEVIEVMHRMREHDIDMLTLGQYLQPSRSHLPVQRFVHPDTFAWFAEEGYKMGFKNVASGPLVRSSYHADQQAHEAKIKL
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_SHIF8
Sequence: MSEQHAQGADAVVDLNNELKTRREKLANLREQGIAFPNDFRRDHTSDQLHAEFDGKENEELEALNIEVAVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLPEGVYNEQFKKWDLGDILGAKGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGLQDQEARYRQRYLDLISNDESRNTFKVRSQILSGIRQFMVNRGFMEVETPMMQVIPGGAAARPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYKDLIELTESLFRTLAQDILGKTEVTYGDVTLDFGKPFEKLTMREAIKKYRPETDMADLDNFDSAKAIAESIGIHVEKSWGLGRIVTEIFEEVAEAHLIQPTFITEYPAEVSPLARRNDINPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFLDQVAAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNX10_MOUSE
Sequence: MFPEQQKEEFVSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFTMKTSCVRRRYREFVWLRQRLQSNALLVQLPELPSKNLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDIEACVSGQTKYSVEEAIHKFALMNRRFPEEEEEGKKDADVEYDSESSSSGLGHSSDDSSSHGCKTSPALQES
What is the function of this protein?
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.  Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.  Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A.  Involved in osteoclast differentiation and therefore bone resorption.
What are the official names of this protein?
Sorting nexin-10.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May also localize to nucleus and endoplasmic reticulum.
Protein: SYN1L_DANRE
Sequence: MESLSELQNPLLDKNSKHMVMADYGYGGDFHSNQYQENIINYFVTGGGGGGGGGGGGGGVAVTGGNGKAKSQLLDATSLHLAVEAFYKPNFILYKDDVSGKGKDYKNECCETTFMEKKDKEVVVETPSTEDPQAKLLDENDVKIQTVSYEVEEEEYVEYETDCSSDSESEDNFIVIPPRDHLGLAIFSMLCCFWPLGIAAFYFSQGTSKAVTKGDFPLASIASRRALFLAALSITIGTGVYVGVVVALIAYLSKPGHI
What are the official names of this protein?
Synapse differentiation-inducing gene protein 1-like, Capucin, Dispanin subfamily C member 1, DSPC1, Transmembrane protein 90A.
What is the protein family that this protein belongs to?
Belongs to the CD225/Dispanin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network.
Protein: UPP_BACSU
Sequence: MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEITRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGLYRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCLVAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: YOUD_CAEEL
Sequence: MSERDAIRAFSHMLETIFVRMRAEGTGSQTDAMQRWLDLYNVGSLPIDKKSYKALRLMDRETTDQQKEDATCAICLDNLQNNVDIPEDHVIKEELKIDPTTFGTTVIVMPCKHRFHYFCLTLWLEAQQTCPTCRQKVKTDKEVEEEERQRNLEELHDSMYG
What are the official names of this protein?
Uncharacterized RING finger protein ZK637.14.
Protein: GATP2_SOLLC
Sequence: MAKTNGFMGHDMLAPFTAAWMIDMGPLVIDKAEGSYVYGVNGKKYLDSLSGLWCTVLGGSEPRLIEAASKQLNKSAFYHSFWNRTTKPSLDLAKELINMFTANKMGKVFFTSSGSEANDTQVKLVWYYNNAIGRPNKKKIISRKNAYHGSTYMTAGLSGLPSLHLKFDLPPPYILHTDCPHYWNYHLPGETEEEYSTRLANNLENLILKEGPETVAAFIAEPVMGGAGVIIPPATYFEKIQAVLKKYDILFIADEVICGFGRLGTMFGCDKYNIKPDLVSIAKALSGGYIPIGAVLVSEEISKVIMSQSNQLGVFCHGFTYSGHPVACAVALEALKIYKEKNITEVVNKLSPKLQEGLKAFIDSPIIGEIRGTGLVLSTEFVDNKSPNDPFPPEWGVGTYFGSQCQKHGMLVSFSGDHVNMAPPFTLSLEELDEMISIYGKALKDTEKRVEELKSQKK
What is the function of this protein?
Transaminase that degrades gamma-amino butyric acid (GABA) and uses pyruvate or glyoxylate as amino-group acceptor.  Cannot use beta-alanine, ornithine, acetylornithine, serine, glycine, asparagine, glutamine, glutamate, valine, leucine, isoleucine, methionine, phenylalanine, histidine, lysine, arginine, aspartate, threonine, tyrosine, tryptophan, proline, or cysteine as amino donors.  May be responsible for establishing the GABA gradient in the carpel.
What are the official names of this protein?
Gamma aminobutyrate transaminase 2, Gamma-aminobutyrate transaminase isozyme 2, LeGABA-TP2, SlGABA-T2.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPPH_BURM7
Sequence: MLDREGFRPNVGIILLNAHNEVFWGKRLREHSWQFPQGGIKYGETPMQAMYRELHEETGLLPEHVKIIGRTRDWLRYEVPDKFIKREVRGHYRGQKQIWFLLRMVGRDCDICLRATDHPEFDAWRWNEYWVPLDAVIEFKRDVYQLALTELSRFLRRPAQRTDKSRGPRAPRYPRVANGHAASEAPAAIDTSAVCSEVEPGANALDETPPRVSLRD
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: UREF_HAHCH
Sequence: MPPLALLKLMNLISPALPVGAFAYSQGLEWAIDHGGIDTPEKIHDWLQGVISQGLGKTDLPVLFKLLQAWGANDHEQINSWNAWLLAARETQELLDEDRHVGKALAKLLRDLNVPGAEPWLERPASLLTLWTLACAHWDIDAESAALGFLWSWLENQIAVAGKTLPLAQTAAQRILQRLMPVLTETVAAATQIKEEDFGASLPGWAMACANHETQYSRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX3_SCHCO
Sequence: MTSIKFYQSFSAHLVQHSPWPILVSFSLFNLAIGTVLTMHGYSHSSTTFDLGLAVTVGSILLWTRDIVIEGSFLGDHTKQVQEGLIIGFILFIISEVFAFISVFWAYFHSALSPAVELGSTWPPVGIIPLDTFSLPLFNTIILLSSGAFVTYGHHAIFSGKRLDSIIGLFLTVALALIFSYFQAFEYIHAGFSMSDSVFGTVFFASTGLHGIHVMLGTLFLFVSFLRQVNYQTTKEHNIGLETSILYWHFVDLVWLFLFLVVYFWGGA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPOB_MYCMM
Sequence: MLEGRILADFRQTDASLHQGRPQSSSNSSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSQRWRESAAQRGDATPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDEVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVYFDETIDKSTDKLLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWSNEQIHERFGFSEIMMGTLEKDNTAGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLNAGQPITSSTLTEEDVVATIEYLVRLHEGQTAMTAPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIHYLTADEEDRHVVAQANSPIDAQGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVADKAGVIEEVSADYITVMADDGTRHTYRMRKFARSNHGTCANQSPIVDAGERVEAGQVIADGPCTQNGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDDDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPAEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWVAKSGWNIDVANGVPEWAGKLPENLLSAQPDSIVSTPVFDGAQEAELQGLLSATLPNRDGEVLVDGDGKAKLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RUVB_LISIN
Sequence: MDERIISSETVDAEEVSFETSLRPQTLSQYIGQDKVKNNLTVFIEAATLRNEALDHVLLYGPPGLGKTTLAMVIASEMGSEIKTTSGPAIERPGDLATILTSLEPGDVLFIDEIHRLSRAIEEILYPAMEDYCLDIVIGTGPTARSVRLDLPPFTLIGATTRAGLLSAPLRDRFGVIDHLEFYTEEQLTEIVLRTSGILDTKIDDLGAREIARRSRGTPRIANRLLKRVRDFAQVRGNGTVTEKLAKEALTLLQVDPRGLDTIDQKLLHTIIQSFRGGPVGLDTIAASIGEERETIEDMQEPYLLQIGFLQRTPRGRIATETAYNHLGISYEKEV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: TRUB_YERPE
Sequence: MGRPRRRGRDINGVLLLDKPLGLSSNDVLQKVKRLFSANRAGHTGALDPLATGMLPICLGEATKFSQFLLDSDKRYRVVARLGQRTDTSDAEGALISEREVNLTQAQIDTALESFRGESQQIPSMYSALKHQGKPLYEYARQGIEVEREARSITVYELLFIRWEGNDLELEIHCSKGTYIRTIIDDLGELLGCGAHVSYLRRLQVATYPSERMVTLEQLTAMVEAAQAEGRSPNPELDSLLLPMDSAVLNFPEVNLLPSVAAYVKQGQPVHVSGAPSEGMVRITEGKERNFIGIGTIAEDGRVAPKRLVVESVEVENLPVENKK
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: HAUS2_PONAB
Sequence: MAAANPWDPASAPNGAGLVLGHFIASGMVNQKNLEIELLKLEKDTADVVHPFFLAQKCHTLQSMNNHLEAVLKEKRSLRQRLLKPMCQENLPIEAVYHRYMVHLLELAVTFIERLETHLETIRNIPHLAANLKKMNQALAKMDILVTETEELAENILKWRKQQNEVSSCIPKILAEESYLYKHDIIMPPLPFTSKVHVQTINAK
What are the official names of this protein?
HAUS augmin-like complex subunit 2, Centrosomal protein of 27 kDa, Cep27.
What is the protein family that this protein belongs to?
Belongs to the HAUS2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Protein: NU2C2_NICTO
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFDGSLIFPECILIFGLILLLMIDSTSDQKDIPWLYFISSTSLVMSITALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATMKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSPAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLYLFWCGWQAGLYFLVLIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPIIAIAQDSLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PUR7_SACEN
Sequence: MVALADYPQIAAGKVRQLHAVDDEHLLLVASDRISAFDHVLSTPIPDKGRVLTAMSVFWFNLLSDVVPNHLVAWDDPRIPAEVRGRALLVRRLEMLQVECVARGYLTGSGLLDYQRTGAVCGVVLPEGLTEASRLPEPIFTPATKAELGAHDENVSFEAVAEAVGQELAAELRELTLRVYGRAAEHARERGVILADTKFEFGVAGGGALVLGDEVLTPDSSRYWPADGYEPGKVQPSFDKQYVRNWLTSAESGWDRASDTPPPPLPDDVVAATRARYVEAYERITGLDLADWPSPAA
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: KAX35_ANDAU
Sequence: MKVFSAVLIILFVCSMIIGINAVRIPVSCKHSGQCLKPCKDAGMRFGKCMNGKCDCTPK
What is the function of this protein?
Has also been shown to inhibit with high potency Kv1. 3/KCNA3 and with low potency Kv1. 1/KCNA1 and Kv1. 2/KCNA2 voltage-gated potassium channels (PubMed:7806508, PubMed:29483648).  Also binds and inhibits the molluscan calcium-activated potassium channels KCa (Kd=135 nM) (PubMed:7806508).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 3.5, Kaliotoxin-2, KTX-2.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 03 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RBY1B_HUMAN
Sequence: MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREAYGSSSYVASIVDGGESRSEKGDSSRY
What is the function of this protein?
RNA-binding protein which may be involved in spermatogenesis.  Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
What are the official names of this protein?
RNA-binding motif protein, Y chromosome, family 1 member B.
What are the subcellular locations of this protein?
Nucleus.