PharMolix/UniProtQA huggingface dataset:
Protein: COBS_THEGJ
Sequence: MRNLLPFFTRIPVKGDFERVRNELWALPLLAPLTSALATLVLYLELPLSNVLAILALYFTTGLLHLDGLADWADGVMVKGDRERKIKAMKDLNTGIAGVFAVVMVFLLQVYSLPLLPFYALYLAELNSKFAMLLALATRKPLGQGLGAYFMEGMNGRQLTLGTALYLLLLLPVAYIEPRSISSLLGLLAGAYVIRLSLRNFGGLNGDCIGAVAEITRAGALLGMAVVWVYFGG
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BR2C_PULPI
Sequence: GLLDSFKNAMIGIAKSAGKTALNKIACKIDKTC
What is the function of this protein?
Has antibacterial activity against the Gram-positive bacterium S. aureus ATCC 25923 (MIC>72 uM) and the Gram-negative bacterium E. coli ATCC 25726 (MIC=18 uM).
What are the official names of this protein?
Brevinin-2PTc.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: SCNNA_MOUSE
Sequence: MLDHTRAPELNLDLDLDVSNSPKGSMKGNNFKEQDLCPPLPMQGLGKGDKREEQALGPEPSEPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYFSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLFDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEEALGSFIFTCRFNQAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGTTPPLALTAPPPAYATLGPSASPLDSAVPGSSACAPAMAL
What is the function of this protein?
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride.  Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells.  Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.  Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands.  Also plays a role in taste perception.
What are the official names of this protein?
Amiloride-sensitive sodium channel subunit alpha, Alpha-NaCH, Epithelial Na(+) channel subunit alpha, Alpha-ENaC, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA.
What is the protein family that this protein belongs to?
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cytoplasmic granule. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non- ciliated epithelial cells, restricted to apical surfaces. In epidermis, located nearly uniformly in the cytoplasm in a granular distribution. In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles. In eccrine sweat glands, mainly located at the apical surface of the cells facing the lumen. In skin, in arrector pili muscle cells and in adipocytes, located in the cytoplasm and colocalized with actin fibers. In spermatogonia, spermatocytes and round spermatids, located in the cytoplasm. Prior to spermiation, location shifts from the cytoplasm to the spermatid tail. In spermatozoa, localizes at the acrosome and the central region of the sperm flagellum.
Protein: NDOA_PSEPU
Sequence: MTVKWIEAVALSDILEGDVLGVTVEGKELALYEVEGEIYATDNLCTHGSARMSDGYLEGREIECPLHQGRFDVCTGKALCAPVTQNIKTYPVKIENLRVMIDLS
What is the function of this protein?
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene (PubMed:6874638, PubMed:2294093, PubMed:10692370).  Functions as an intermediate electron transfer protein via a specific interaction with iron sulfur protein components (ISP) (NdoB and NdoC) (PubMed:2294093).  Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene (PubMed:10692370).
What are the official names of this protein?
Naphthalene 1,2-dioxygenase system, ferredoxin component.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin component family.
Protein: OSBP1_HUMAN
Sequence: MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGPGAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWSSCPDIF
What is the function of this protein?
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621).  Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193).  Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430).  Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).
What are the official names of this protein?
Oxysterol-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
Protein: LTOR3_HUMAN
Sequence: MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELRQVVEVS
What is the function of this protein?
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag.  Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.  Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
What are the official names of this protein?
Ragulator complex protein LAMTOR3, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MEK-binding partner 1, Mp1, Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein kinase scaffold protein 1.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR3 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CPNB3_ARATH
Sequence: MASTFSATSSMGSSLAPPSNRLSSFVSISSSSFGRTQSIAQRKARFPKIYAAKQLHFNKDGTAIKKLQAGVNKLADLVGVTLGPKGRNVVLESKYGSPRIVNDGVTVAREVELEDPVENIGAKLVRQAASKTNDLAGDGTTTSVVLAQGLIAEGVKVVAAGANPVLITRGIEKTTKALVAELKKMSKEVEDSELADVAAVSAGNNYEVGNMIAEAMAKVGRKGVVTLEEGKSAENSLYVVEGMQFDRGYISPYFVTDSEKMCAEYENCKLFLVDKKITNARDIISILEDAIKGGYPLLIIAEDIEQEPLATLVVNKLRGTIKVAALKAPGFGERKSQYLDDIAALTGATVIREEVGLQLEKVGPEVLGNAGKVVLTKDTTTIVGDGSTEEVVKKRVEQIKNLIEAAEQDYEKEKLNERIAKLSGGVAVIQVGAQTETELKEKKLRVEDALNATKAAVEEGIVVGGGCTLLRLASKVDAIKETLANDEEKVGADIVKKALSYPLKLIAKNAGVNGSVVSEKVLSSDNPKHGYNAATGKYEDLMAAGIIDPTKVVRCCLEHASSVAKTFLMSDCVVVEIKEPESAAPAGNPMDNSGYGF
What is the function of this protein?
Involved in protein assisted folding.
What are the official names of this protein?
Chaperonin 60 subunit beta 3, chloroplastic, CPN-60 beta 3.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL15_RALPJ
Sequence: MQLNNLKPAAGSKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGFHKVGFEGGQMPLHRRLPKRGFTSLTKEFTAEVRLGDLAGLPIEEVDLLSLKQAGLVGEMVKSAKVILSGEIDKKVTLKGIGATAGAKAAIEAAGGSLA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PTYBC_VIBPA
Sequence: MAKITSNTVSQLLSAVGGSSNVSKCGNCMTRLRLSLANNGLADQSVIKKIPGVMGVVESDEQFQIILGPGKAQQAAEMMNQLIDSLTSGDSEEPDMPQQDLSAVAAEQKKQMKSKQTSAVQRFLSKFATIFTPLIPGFIAAGLLLGFATLLEQMFVLDQTPSQFMLDLIAYMKVFGKGLFAFLSILIGYNAQQAFGGSGVNGAILASLFVLGYNPEATSGIYSGMNEFFGFAIDPRGNIIGVLLAAIIGAQVERKVRQYMPDDLDMILTSVITLLIMGAVTFLIIMPIGGELFKGMSWLFLNLNDNPLGAAILAGLFLISVVFGIHQGFVPVYFALMEAQGFNSLFPILAMAGGGQVGASMALYFKAKKDALLRTQVKGAIIPGLLGIGEPLIYGVTLPRVKPFVTACIGGAAGGFFIGLVSYLGLPVGLNTVFGPSGIVAIPLMTSENGIFPGMMVFVAGLLISYIVGFLATYFFGCKDVDLS
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P.  Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring.
What are the official names of this protein?
PTS system N-acetylmuramic acid-specific EIIBC component, EIIBC-MurNAc.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYSH_XYLFT
Sequence: MTVLPALPPLDDLETLNVHLETLSAENRVCWALEHGPDHPALSSSFGAQSAVMLHLLTRFAPDITVILVDTGYLFPETYRFADTLTERLKLNLKVYQPLRSGAWTEARHGRLWEQGIDGINQYNTLHKVEPMRRALEELQVGTWFTGLRRGQSSTRTQTSIVQRRDERYKISPIADWTDRDIWEYMKHHDLPYHPLWEQGYVSIGDIHTTRPLEPDMREEDTRFFGFKRECGIHENI
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_RICAE
Sequence: MNNLKQGKFITFEGGEGIGKSTQSQMLYEYLQSQNTPVILTREVGGTIVAEKMREILVHEELLPISELLQVMAARYDHMARKIIPALQEGHIVICDRFIDSTVCYQGLELENGIDLVYNLHKTLMPSLMPDITFFIDVEPDTAIKRVNSRNMNNKFDIRGIDFYKKIYYCFKELSNRFPERIKTIKASDLSPLEVHELIKKHL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: APT_OENOB
Sequence: MDIDLHDYIATTPDFPEKGVMFRDINPLIGNGPAYRQAINELIDFARPLKPDIIAGPEARGFVVGSPMAYALGIGFVPARKYGKLPRKSVSSSYSLEYGKNELQMHVDSIKPGQRVFIVDDLLATGGTITATMDLVRQLGGQVVGTGFFIELADLQGRKKIMEVENVPFKSLLEY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3SA7_NAJNA
Sequence: LKCNKLIPLAYKTCPAGKDLCYKMYMVSNKTVPVKRGCIDVCPKNSLLVKYECCNTDRCN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pore in lipid membranes.  In vivo, increases heart rate or kills the animal by cardiac arrest.  In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity (By similarity).  Preferentially binds acidic phospholipids like phosphatidylserine, phosphatidic acid and phosphatidyl glycerol (PubMed:26456928).  Has hemolytic activity towards human erythrocytes (EC(50)=0. 171 uM) and cytolytic activity towards various cell lines (PubMed:26456928).
What are the official names of this protein?
Cytotoxin 7, CTX7.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: PFKAP_PONAB
Sequence: MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVCFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSSVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKETRGRGKKFTTDDSVCVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWSV
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, platelet type, ATP-PFK, PFK-P, 6-phosphofructokinase type C, Phosphofructo-1-kinase isozyme C, PFK-C, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA_STRPJ
Sequence: MKILFVAAEGAPFSKTGGLGDVIGALPKSLVKAGHEVAVILPYYDMVEAKFGNQIEDVLHFEVSVGWRRQYCGIKKTVLNGVTFYFIDNQYYFFRGHVYGDFDDGERFAFFQLAAIEAMERIDFIPDLLHVHDYHTAMIPFLLKEKYCWIQAYEDIETVLTIHNLEFQGQFSEGMLGDLFGVGLERYADGTLRWNNCLNWMKAGILYANRVSTVSPSYAHEIMTSQFGCNLDQILKMESGKVSGIVNGIDADLYNPQTDALLDYHFNQEDLSGKAKNKAKLQERVGLPVRADVPLVGIVSRLTRQKGFDVVVESLHHILQEDVQIVLLGTGDPAFEGAFSWFAQIYPGKLSANITFDVKLAQEIYAACDLFLMPSRFEPCGLSQMMAMRYGTLPLVHEVGGLRDTVRAFNPIEGSGTGFSFDNLSPYWLNWTFQTALDLYRNHPDIWRNLQKQAMESDFSWDTACKSYLDLYHSLVN
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: CTAA_AGRFC
Sequence: MANGSVDMVVEAALQKQEKDRRLLRIWLRVVLFTLFCLVLVGGATRLTESGLSITEWKPIHGAIPPLSVAEWEEEFQLYKRIPQYQEINKGMSLDEFKTIFWWEWAHRLLARTIGLVFALPLAFFWLTGRVEKRLRLPLVGLLALGGFQGFVGWWMVSSGLVNRTDVSQYRLATHLTIACLIFAGCMWILRGLSHHSPDAADERTGRGFAALLTVLCLFQIYLGALVAGLNAGLSYNTWPLMDGSLVPGDLFLQQPWWINLFENPKTVQFVHRLGAYTLFAATLWHMVSMARALPGTPHARRAVLFFVLISVQAGLGITTLLMHVDIHVALAHQGMALILLGFSVAHWRGFIGEYPAPVAVEVRD
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AMPA_PHYAS
Sequence: MKIYFKKNYLPSMDVDTAVVLQVEKYENSFGLEAVDPKGVAKKSFLRENFKGVFGTQVKLLYPEGSPVACLQVMGLGKQEEINDQTFLKTGGLCFPQLNKANKVVVFADALGIENQTSQVMHFALGLLLRSYSFKHYHTQKTKNEKNLEITFITENAELCQKEFDDVKAILGGVNLTKELVNEPANILGTNEFVERTQQLQTLGVEVEVLNKETLEKLGMNALLGVAQGSQRPPYLVVMKWLGGNENEKPVAFVGKGVVFDTGGISLKPSNKMEDMKGDMAGAATVVGLMHALAARKAKVNVLGVIGLVENMPGSNAQRPGDIVTSMSGQTIEVINTDAEGRLVLADALWYCKTKLQPKMIIDLATLTGAIVVALGYEYAGLFSNNKELVKQLVHSGEVTEEKVWQFPLGPEYDRLVDGKFADISNCPVGYGAGSITAAQFLKRFVGDDIPWAHIDIAGVASGKKKNEFNSSWASGFGVRLLNHLVKDYYENK
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_RICCN
Sequence: MNIIDRFEQENISKRTANKKIPDFEAGDTVKVTVKIIDRSIEKDGKEKLTERFQAYEGVVIAKRNRGITSSFLVRKISHGEGVERRFMTYSPMVHSIDVVKYGVVRRAKLYYLRNRSGKSARIKERHIPIAKTKAAKA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: PG024_VACCW
Sequence: MSSKGGSSGGMWSVFIHGHDGSNKGSKTYTSGGGGMWGGGSSSGVKSGVNGGVKSGTGKI
What are the official names of this protein?
OPG024 protein.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG024 family.
Protein: CP7A1_CRIGR
Sequence: MMTISLIWGIAMVVCCCIWVIFDRRRRKAGEPPLENGLIPYLGCALKFGSNPLEFLRANQRKHGHVFTCKLMGKYVHFITNSLSYHKVLCHGKYFDWKKFHYTTSAKAFGHRSIDPNDGNTTENINNTFTKTLQGDALHSLSEAMMQNLQFVLRPPDLPKSKSDAWVTEGMYAFCYRVMFEAGYLTLFGRDTSKPDTQRVLILNNLNSFKQFDQVFPALVAGLPIHLFKAAHKAREQLAEGLKHENLSVRDQVSELIRLRMFLNDTLSTFDDMEKAKTHLAILWASQANTIPATFWSLFQMIRSPDALRAASEEVNGALQSAGQKLSSEGNAIYLDQIQLNNLPVLDSIIKEALRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPAIYPDPLTFKYDRYLDENKKAKTSFYSNGNKLKYFYMPFGSGATICPGRLFAVQEIKQFLILMLSYFELELVESHVKCPPLDQSRAGLGILPPLNDIEFKYKLKHL
What is the function of this protein?
Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol.  Important for cholesterol homeostasis.
What are the official names of this protein?
Cholesterol 7-alpha-monooxygenase, CYPVII, Cholesterol 7-alpha-hydroxylase, Cytochrome P450 7A1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: SYFB_PYRAE
Sequence: MPVIDVAKSDLERLTGLKYEEIAKLFEYIKGEIESDSGERLRIEVTHDRPDHFSAEGLAKTLKGIAEIEVGLPRISLGRSSIRLVAESITERPYIAMAVVRNVRLDEEAIKQMIQLQEKLHETYGRGRRKIAIGFYDVSKIKPPIYYRRISQEDEYIPLGFQKPVKVREMYELTEQGRRYSGLINRENPPALVDASGQIMVVIPVLGSECCKITEATRDVLIDVTGTDHRAVANALSILIYSLLERSGSKEVEIVEGGTGYSHEYVKIYVDERAVSEFLGVKIAHEDFIKYIKKARFDYQEGAVIIPPYRINVLSWVDVAEDVAIVMGYNQMPREVPEIPSAGRRHRTEVITLEVRKSMLSMGFTELNNYVLTDEAVAEVCSPARVANPISELYTTIRCSIITQLISAASALKRRETKIFEVGEVVREGRTVRALAFLISRDGATLTDGLSVVKSLCKRLGLKCEFFPAEAKWALPNRMAEVRGEITGYIAEVNPDVLTALKHAVPTVVAELYIG
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUON_YERPA
Sequence: MTITPQQLIAMLPLLIVGLTVVVVMLSIAWRRDHFINATLTVIGLNLALLSLYFVGQVGPMDVTPLMRVDGYSMFYTGLVIIASLATSTFAYPWLVGYPDNREEFYLLVLIAALGGILLASANHLASLFLGIELLTLPLFGLIGYAYRQKRSLEASIKYMLLSAAASSFLLFGMALLYAESGSLSFVGLGQSLSDSMVHQPLILAGLGMMIVGLGFKLSLVPFQLWTPDVYQGAPAPVSTFLATASKIAIFAVVMRLFMYAPAADSEAVRLVLSIIAVASILFGNLMAISQTNIKRLLGYSSIAHLGYLLIALVAVQTHELALPLETIGVYLAGYLFSSLGAFGVVSLMSSPYKGPDAESLFSYRGLFWHKPILSAVMTVMMLSLAGIPMTLGFIGKFFVVAMGVSANLWWLTGAVVLGSAIGLYYYLRVTVSLFLSPPQSLVRDTPSNWALTAGGVVVLISAILVLVLGIYPQPLITLVQMAQPLM
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL14_RHOPS
Sequence: MIQMQTNLDVADNSGARRVMCIKVLGGSKRRYATVGDVIVVSIKEAIPRGKVKKGDVMKAVVVRVRKDIRRPDGSVIRFDRNAAVLINNQSEPVGTRIFGPVPRELRAKNHMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: HISZ_BRUO2
Sequence: MVGSRTSPIFNALRVELNAREAELVEIPLIQPADPFLDMAGEDLRRRIFLTENENGDSLCLRPEFTIPVCRNHIALNAATPKRYAYLGEVFRQRRDGAAEFLQAGIEDLGAADEAASDARSLADALSCVKAIAPDAPLEIVLGDQSVFAGMLKALGLPQGWRKKLLRSFGDAHSMDLALAELTGTQRRDPLPESLAVLVAEGDEIGLARMLEAEMLEAGISPGAGRTPVEIARRLIEKEDLAATHFPAAALDLLRQFLAIRVSLDMAAVTLRAFAADNALDLGAVLQKFEARADAIAQAGIEMKDIIYDASFGRPLDYYTGLVYEIRDASNRQDGVLAGGGRYDRLLTMLGACEAIPGVGFSIWLDRLQALAGEKQ
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.