PharMolix/UniProtQA huggingface dataset:
Protein: CDC42_RAT
Sequence: MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
What is the function of this protein?
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.  In active state binds to a variety of effector proteins to regulate cellular responses (PubMed:25498153).  Involved in epithelial cell polarization processes.  Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (By similarity).  Regulates cell migration (By similarity).  In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity).  Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons.  Facilitates filopodia formation upon DOCK11-activation (By similarity).  Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (PubMed:21423166, PubMed:25498153).  Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity).
What are the official names of this protein?
Cell division control protein 42 homolog.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, dendrite. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome. In its active GTP-bound form localizes to the leading edge membrane of migrating dendritic cells.
Protein: NODP_RHIS3
Sequence: MNVPLTHLQRLEAESIHIFREVAAAFTKPVMLYSVGKDSSVLMHLAMKAFYPAKPPFPFLHVDTTWKFREMIAFRDQMAQKRGFDLLVHFNEDGVRDNINPFDHGSNTHTHVMKTVALRQALDKYGFDAAFGGARRDEEKSRAKERIFSFRNAQHVWDPKNQRPEMWKIFNTRIASGESIRVFPLSNWTELDIWQYILQENIPIVPLYFAKQRPVVERDGMLILRDDERMKLRPGETVENRLVRFRTLGCYPLTGAIESDADTLEAIVGEMLTARTSERQGRLIDRDEAGSMEKKKREGYF
What is the function of this protein?
Proposed to provide activated sulfate for transfer to nod factor.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Nodulation protein P, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: PANC_CAMJE
Sequence: MQVITSVKEAKQIVKDWKSHQLSIGYVPTMGFLHDGHLSLVKHAKTQDKVIVSIFVNPMQFGPNEDFSSYPRDLERDIKMCQDNGVDMVFIPDATQMYLKNFSTYVDMNTITDKLCGAKRPGHFRGVCTVLTKFFNILNPDIVYMGQKDAQQCVVVRHMVDDLNFDLKIQICPIIREEDGLAKSSRNVYLSKEERKASLAISQSIFLAEKLVREGEKNTSKIIQAMKDILEKEKLIKIDYIELVDFNTMENIENITDNVLGAVAAFVGKTRLIDNFLVQGLK
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_BARHE
Sequence: MSHNTFGHLFRVTTWGESHGEALGCVIDGCPPGITFTLSDIQSYLNKRKPGQSKYTTQRRELDQVEILSGVIVQDDGITFVTTGTPISLLIRNMDQRSKDYSAIVHQYRPGHADYTYDVKYGIRDFRGGGRASARETAARVAAGAVARKIIPGVIVRGAVIAIGPHTINRNRWNWSEVDNNPFFTPDAEMVQVFSDYIDKVHKNGSSVGAVVEIVAENIPAGLGAPIYAKLDQDIASLLMSINAVKGVEIGDGFAAARLTGEENADEMRMGSDGKPLFLSNHAGGIVGGISSGQPIIARFAVKPTSSILIPRRSIDVDGNDVNVITKGRHDPCVGIRAVPVGEAMVACALADHYLRHRGQVGCFKR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RS3_PARUW
Sequence: MGQKVNPISFRLVRTRDWRSKWFANKKEFGDLLVEDQIIRAYLLKKPALVGVSAIKIKRMSGKVEVTIVTARPGLVIGKKGAEIDVLKGELSKLTGKEVWVAVEEVKRPDMDAKIVADSIAKQLERRIPFRRAMKKAMQSSIDAGAFGIKVQLSGRIGGAEIARTEWYKEGSTPLHTLRADIDYATGRAETTYGSIGVKVWIYRGEDNLAKKEA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PUR5_ALBFT
Sequence: MTQKNASSASPLSYKDAGVDIDAGDALIERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKEPVLVSGTDGVGTKLKLAFEWNMHDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLDVDTAAAVVGGVAKGCELSGCALIGGETAEMPGMYPPGEYDLAGFCVGAVEKSKILTGVAIKPGDVVMGLASSGVHSNGFSLVRKCIERAGANAPATLDGKPFKQALMEPTRLYVKNVLAALAAHPIKALAHITGGGLLENIPRVLPEGTAAHLTKGSWPQTELFAWLQKTAGIDDFEMNRTFNNGIGMVVVIDASQAAACAATLRAAGEAVYVIGVIAARGDDAAVLVR
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTAA_LISW6
Sequence: MKKFLKVWSVLTIICMTVVVFGGALVTKTGSADGCGNSWPLCNGQLVRLTDVTPEKLIEFMHRMTTGISSIFVIVLAICAWIYMKNRRETKPLAIIAVLFLIIQALMGMAAVVWGQNPYIMALHFGISIICYASIVLLALMIFEVDRKFDARNLVMGTKLRINIYALTIYTYLAVYTGALVRHEKASMAVPVWPFENGKFIMPDSVQDYVQYFHRVAAFILIVWLLYVTWLVFRDYRRYRVLTFSMVLSLLFIALQAVTGALSVYTGVNLYIALAHSLIITMLFALLCYLCLLASRSKSNRLRIK
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS20_COXBR
Sequence: MANSAQAKKRARQNEKRELHNASQRSAVRTAVKKILKSLQANDSSAAQSAYQHAVQILDKAAGRRIIHPNKAARLKSRLSQKIKNLSSSQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RL27_STRA5
Sequence: MNLANLQLFAHKKGGGSTSNGRDSQAKRLGAKAADGQTVSGGSILYRQRGTHIYPGANVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPIAK
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PDH_ARMVU
Sequence: MIGKYLSWFMLAFLFGFVLESYRVQSQDLNPTEKEVLSNMLDFLQRHSRTTYMFPLLSESKRNSELINSLLGAPRVLNNAGR
What is the function of this protein?
The pigment-dispersing hormone causes the migration of the distal retinal pigment into the proximal end of the pigment chromatophore cells and thus decreases the amount of light entering the retinulas.  May also function as a neurotransmitter and/or neuromodulator (By similarity).
What are the official names of this protein?
Pigment-dispersing hormone peptides, AvPDH.
What is the protein family that this protein belongs to?
Belongs to the arthropod PDH family.
What are the subcellular locations of this protein?
Secreted.
Protein: SLYX_YERE8
Sequence: MEQSLFEQRLEMLESRLAFQEVTIEELNLIVTEHQMEMTKLREHLRLLTDKLRESQSSMMASPAEEPPPHY
What are the official names of this protein?
Protein SlyX.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: NECT1_HUMAN
Sequence: MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
What is the function of this protein?
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.
What are the official names of this protein?
Nectin-1, Herpes virus entry mediator C, Herpesvirus entry mediator C, HveC, Herpesvirus Ig-like receptor, HIgR, Nectin cell adhesion molecule 1, Poliovirus receptor-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein. Presynaptic cell membrane. SUBCELLULAR LOCATION: [Isoform Delta]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform Gamma]: Secreted.
Protein: DDL_BUCBP
Sequence: MTIITEKIAVLLGGTSQERNISLISGYNILNSLLKSGIHAVAIDTKDFPITQLPHQKFTKAFIALHGRDGEDGTIQSVLKYLNIPFTGSKTLPSAISINKFKTKLLWQSFNLPVVPYLHINKHEFNKKFLQKFKKNISLLGLPIIVKPNQEGSSIGITIVYSYETLYKACKTAFIFDNSILIEKFIYGEEYTISILGKKILPIIRICPENTFYNYNSKYLSNRTTYFCPSGLNKLKELELKKITLTAWNIIDGTGWGRVDVIMDYKNKFWLLEANTCPGMTDHSLFPMSAKKAGISYQILVQKILELAN
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FB162_ARATH
Sequence: MTIPDLCNDLVDEILCRVPARNLKRLRSTSKRWNRLFKDDRRFAREHMHKAPKEYLPLMLTSEYRICPVSINLQGDVPSVVLKRELSLPDPDYSHQFDIGRVFHCDGLLVCNHVGKNPRYGSKIVVWNPLTGQTRWIEAGYRWKEYEVRFVLGYCYQQDENNSCSKKIYKILCFYPNGQDTEIYELNYSDRWTRTIPDGDLTPGWTLIYSEQTVSMNGNLYLFASEKSKPHLGVSLLRFDFSTEKSSLCVTLPYQRPRYEILSISAVRGGENLSLLLQLDFESKTEIWVTNKIDDTTTKGAAVSWTKVLAFDLSPDLQLFSEEVNFLLDEDKKVAVCCERWLEPQEHHRYQCRREYKITDKIYILGEDNKVDEVGSGEGEATDSLEGISQVILNYAPSLVQIEQAGGGKTKRGDD
What is the function of this protein?
Negative regulator of EIN2 protein stability.
What are the official names of this protein?
F-box protein ETP1, EIN2 targeting protein 1.
Protein: HIS5_CHLAA
Sequence: MIAVINYGAGNLPNVVRALQRVGATLTVTDNPEVIRSAQAVVLPGVGATADTMASLRHLGIAEVLPAVIAASTPFLGICVGMQVLLSESEEFGLHSCLDIIPGTVRRLPEHAGKIPQIGWNQLQISPTFRNHPLFADIPDGADVYFVHSYYCAVADEAIIAARTDYGIPFPSVIIRDHLAAVQFHPEKSGDYGLRLLANFVRWSEAVQPKGV
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_CUPPJ
Sequence: MLYPKEFDVIVVGGGHAGTEAALAAARMGCQTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDAMGGAMAAATDEAGIQFRILNSSKGPAVRATRAQADRVLYRKAIRTRLENQPNLMLFQQAVDDLLVEGDRVVGAVTQVGIAFRARAVVLTAGTFLDGKIHVGLDNYTGGRAGDPASVSLSARLKELKLPQGRLKTGTPPRIDGRTIDFSVMEEQPGDLDPVPVFSFLGRPEQHPQQLPCWISHTNSRTHDIIRGGLDRSPMYTGVIEGVGPRYCPSIEDKIHRFASKDSHQIFLEPEGLTTNEFYPNGISTSLPFDVQLELVHSIRGLENAHILRPGYAIEYDYFDPRALKASLESKAISGLFFAGQINGTTGYEEAAAQGLLAGINAGCYVRERDAWTPRRDQAYLGVLVDDLITRGVTEPYRMFTSRAEFRLSLREDNADMRLTEVGRELGVVDDVRWDAFNRKRDAVSRETERLKSTWVNPTILPAEDAVPLLGKPIEREYSLADLLRRPEVVYNDLMALQGGRHAPEVPLDGDPLLMDQIREQIEIGVKYHGYIARQAAEVDKLEANESTRLPEGLDYTEVRGLGFEVSQKLNQHRPETLGQASRISGVTPAAISLLLVHLKKKGLGRTRSGNSQEAA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIE_SHIF8
Sequence: MSAIQGIEGVISQLQATAMSARAQESLPQPTISFAGQLHAALDRISDTQTVARTQAEKFTLGEPGVALNDVMTDMQKASVSMQMGIQVRNKLVAAYQEVMSMQV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: TRUA_AYWBP
Sequence: MQHFFYKLILSYDGTFYCGYQKQPQKKTVQQTFEKALKKMTHQNIPTFAASRTDKGVHSQGQTLHFQTTFSLKPKHFQKTLNYLLPPDIRVRQMHFATPNFHARYSAKSKIYQYVFSKKPLNAFNHHFQIFADKFDFVKITKALKFIEGTHNFFAFTSETQPKNFSKTIFQASLKETVHKYILVFHGNGFLKYMIRFLVGSLIEIGKNKFSLEQFQAMLLGNKTKKATLLAPAKALVLKKIFY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: Y1023_FRATM
Sequence: MNFDMSKLVQQAQKMQEQMKKAQQERENMEVIGESGAGLVTVTMTGKYDVKSVSIDNSLMSEDKEILEDLIAAAVNSAVKKVEENSTASSDIYKMAKDAGIDLPSGINFPFK
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein FTM_1023.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: FUT1_PIG
Sequence: MWVPSRRHLCLTFLLVCVLAAIFFLNVYQDLFYSGLDLLALCPDHNVVSSPVAIFCLAGTPVHPNASDSCPKHPASLSGTWTIYPDGRFGNQMGQYATLLALAQLNGRQAFIQPAMHAVLAPVFRITLPVLAPEVDRHAPWRELELHDWMSEDYAHLKEPWLKLTGFPCSWTFFHHLREQIRSEFTLHDHLRQEAQGVLSQFRLPRTGDRPSTFVGVHVRRGDYLRVMPKRWKGVVGDGAYLQQAMDWFRARYEAPVFVVTSNGMEWCRKNIDTSRGDVIFAGDGREAAPARDFALLVQCNHTIMTIGTFGFWAAYLAGGDTIYLANFTLPTSSFLKIFKPEAAFLPEWVGINADLSPLQMLAGP
What is the function of this protein?
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens.  H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity).  Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity).
What are the official names of this protein?
Galactoside alpha-(1,2)-fucosyltransferase 1, Alpha(1,2)FT 1, Fucosyltransferase 1, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1, Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1, Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 11 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Protein: IF1C_ZYGCR
Sequence: MKKQNLIEMEGVVTESLPNAMFRVYLDNGCEVLAHISGKIRRNYIRILLADRVKVELSPYDLTKGRITYRLRTKSNG
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NUDK_YERP3
Sequence: MSVKIENIQCELLSKNWFKLHKYTFDLKTDEGTSVQQIREVYDRGNGATILLYNRQQGTVVLIEQFRMPTYVNGNASGMLLEACAGLLDNDSPEACIRREAMEETGYQVDKVQKLFEAYMSPGGVTELVYFFAAEYHPDQKITDEVGVEDEVIEVVELPFHDALAMVADGRIKDGKTIMLLQYAQIHFFPSSLTPQRC
What is the function of this protein?
Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.
What are the official names of this protein?
GDP-mannose pyrophosphatase, GDP-mannose hydrolase, GDPMK.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudK subfamily.
Protein: RUVA_VIBC3
Sequence: MIGRLRGTLIEKLPPQILIEVGGIGYEVQMPMSCIYELPNIGEEAIIYTHFVVREDAQLLYGFNTVSERALFREVIKANGVGPKMGLAILSGMTANQFVTCVEKEDISTLIKLPGVGKKTAERLVVEMKDRLKGWGAGDLFTPATDAAPVDSTPVIAQNAQEEAMSALLALGYKPPQASKAVSQVAKAGMSSEELIREALKSMV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: HUTH_STAA9
Sequence: MTLYLDGETLTIEDIKSFLQQQSKIEIIDDALERVKKSRAVVERIIENEETVYGITTGFGLFSDVRIDPTQYNELQVNLIRSHACGLGEPFSKEVALVMMILRLNTLLKGHSGATLELVRQLQFFINERIIPIIPQQGSLGASGDLAPLSHLALALIGEGKVLYRGEEKDSDDVLRELNRQPLNLQAKEGLALINGTQAMTAQGVISYIEAEDLGYQSEWIAALTHQSLNGIIDAYRHDVHSVRNFQEQINVAARMRDWLEGSTLTTRQAEIRVQDAYTLRCIPQIHGASFQVFNYVKQQLEFEMNAANDNPLIFEEANETFVISGGNFHGQPIAFALDHLKLGVSELANVSERRLERLVNPQLNGDLPAFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPASVDSITSSANQEDHVSMGTTAARHGYQIIENARRVLAIECVIALQAAELKGVEGLSPKTRRKYEEFRSIVPSITHDRQFHKDIEAVAQYLKQSIYQTTACH
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_PECAS
Sequence: MKVGIIGAMEQEVTLLRDRIENRQTFQRAGCEIYTGQINGVEVALLKSGIGKVSAALGTTLLLEHSKPDVVINTGSAGGLASTLNVGDIVISDEVRYHDADVTAFGYEPGQMAGCPAAFPADEKFIALAQDAIDDLQLNAVRGLVVSGDAFINGAEPLARIRTTFPKAIAVEMEATAIAHVCHQFGTPFVVVRAISDVADKASHLSFDEFLSVAAQQSTRMVEAILAKLAAR
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: SUCC_MICLC
Sequence: MDLYEYQARDLFEAHGVPVLAGIVAQTPDEAKAAAEKIGGVTVVKAQVKVGGRGKAGGVKVAKTADEAYEHAKAILGMDIKGHTVHQVMIAQGADIAEEYYFSVLLDRANRTYLAMCSVEGGMEIEQLAEERPEALAKVPVSALTGIDAETAQKIVAEAGFPEELRADVAEVIQKLWEVFEKEDATLVEVNPLVKTGDGKILALDGKVSLDDNAEFRQEGHAALVDERTEDPLEAKAKANDLNYVKLDGQVGVIGNGAGLVMSTLDVVAYAGEKHGGVKPANFLDIGGGANAEVMANGLDVILGDEQVKSVFVNVFGGITACDAVANGIVKALEILGDAATKPLVVRLDGNAVEEGRRILQEANHPLVTLAATMDEGADKAAELAHTAN
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: DTD_DELAS
Sequence: MISILQRVKQARVEIDGQVAGSIGPGLLALVCAERGDTEAEADKLLAKMLKLRIFADDAGKMNRSVQDLDGQGACGGLLIVSQFTLAADTGGGNRPSFTRAAPPAEGERLYDYIVQRARALHPEVATGRFGADMQVHLLNDGPVTIPLSIAPATAA
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.