PharMolix/UniProtQA huggingface dataset:
Protein: VPR_HV1H2
Sequence: MEQAPEDQGPQREPHNEWTLELLEELKNEAVRHFPRIWLHGLGQHIYETYGDTWAGVEAIIRILQQLLFIHFRIGCRHSRIGVTRQRRARNGASRS
What is the function of this protein?
During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest.  Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 E3 ligase complex by direct interaction with host VPRPB/DCAF-1.  Cell cycle arrest reportedly occurs within hours of infection and is not blocked by antiviral agents, suggesting that it is initiated by the VPR carried into the virion.  Additionally, VPR induces apoptosis in a cell cycle dependent manner suggesting that these two effects are mechanistically linked.  Detected in the serum and cerebrospinal fluid of AIDS patient, VPR may also induce cell death to bystander cells.
What are the official names of this protein?
Protein Vpr, R ORF protein, Viral protein R.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPR protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host extracellular space. Note=Incorporation into virion is dependent on p6 GAG sequences. Lacks a canonical nuclear localization signal, thus import into nucleus may function independently of the human importin pathway. Detected in high quantity in the serum and cerebrospinal fluid of AIDS patient.
Protein: LIPA_YEAS1
Sequence: MYRRSVGVLFVGRNTRWISSTIRCGTSATRPIRSNALNTDSDNASVRVPVGNSTEVENATSQLTGTSGKRRKGNRKRITEFKDALNLGPSFADFVSGKASKMILDPLEKARQNTEEAKKLPRWLKVPIPKGTNYHKLKGDVKELGLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRTPSKPDPMEPENTAEAIKRWGLGYVVLTTVDRDDLVDGGANHLAETVRKIKQKAPNTLVETLSGDFRGDLKMVDIMAQCGLDVYAHNLETVESLTPHVRDRRATYRQSLSVLERAKATVPSLITKTSIMLGLGETDEQITQTLKDLRNIQCDVVTFGQYMRPTKRHMKVVEYVKPEKFDYWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRNMK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y6425_RICAH
Sequence: MKKLLLIATTSATILSSSISFADDMGNEWYLRVDAGAAMFNKEQDKATSVKLKSNTTVPVDLGIGYYIFENFRADLTLGTIIGGKLKASGSATHAPFTGTNVSVSHKPTITRLLINGYVDLTNFDLFDVFAGAGVGPALVKEKITYNGITGLSSNTKNRTNISYRLTLGTSAQIADGVKAELAYSWIYDGRTKSKNVIYQGTSVLTGGMRYQSHNLTAGIRFDI
What are the official names of this protein?
Putative adhesin A1C_06425.
Protein: ASSY_RHOPB
Sequence: MSTILKSLPKGENVGIAFSGGLDTSAALLWMKQKGARVFAYTANLGQPDEADYDEIPRKAMEFGAEKARLVDCRSQLVHEGIAAIQSGAFHVSTGGVAYFNTTPLGRAVTGTMLVSAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNPDLRIYKPWLDQQFIDELGGRAEMSAFMTAHGFAYKMSSEKAYSTDSNLLGATHEAKDLEHLDSGIRIVNPIMGVPFWRDDCAVAAETVSVRFAEGQPVALNGKTFTDPVALFLEANAIGGRHGLGMSDQIENRIIEAKSRGIYEAPAMALLHIAYERLVTGIHNEDTIEQYRISGMRLGRLLYQGRWFDSQALMLRETAQRWVARAITGEVTLELRRGNDYSILNTQSPNLTYAPERLSMEKVEDAPFTPGDRIGQLTMRNLDITDTRAKLDLYAKSGLLSAGEGSHIPKLESDKG
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_CORU7
Sequence: MRLVLLGPPGAGKGTQAQLLSDALNIPHISTGDLFRANISQGTELGKQAQEYMDAGKLVPTEVTANMVRARLEEADAANGFLLDGFPRTIEQADLLEEMLKEKDLKLDAVINYQVSEDVVVERMLSRGRNDDNESTIRTRLQVYREETAPLIDYYQGRILNIDAEGSVEDISEATLCALDK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_ACAM1
Sequence: MAIVSSKQSPQPDGSKKPSQAKSVKKSVEHSKPQQTDALLQPEAVQEEFVGKQDDKLRPQRFDEYIGQRELKEVLDIAIQATKSRQEALDHLLLYGPPGLGKTTISLILAAELGVNCKVTSAPALERPRDIVGLLVNLQPRDILFIDEIHRLSRMTEELLYPAMEDFRLDITIGKGQSARIRSLPLKPFTLVGATTRVGALTSPLRDRFGFVQRLRFYEADELGQIVLRTADILKAKITSDAAEEVARRSRGTPRIANRLLKRVRDYAEVKHSGEITQTIAQEALELFNVDPCGLDWTDRRLLTVMIEQYNGGPVGVDTLAAATGEDSQTIEEVYEPYLMQIGYLNRTPRGRVATPAAWTHLGYQPPDEQMRLLS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ATRN1_HUMAN
Sequence: METGGRARTGTPQPAAPGVWRARPAGGGGGGASSWLLDGNSWLLCYGFLYLALYAQVSQSKPCERTGSCFSGRCVNSTCLCDPGWVGDQCQHCQGRFKLTEPSGYLTDGPINYKYKTKCTWLIEGYPNAVLRLRFNHFATECSWDHMYVYDGDSIYAPLIAVLSGLIVPEIRGNETVPEVVTTSGYALLHFFSDAAYNLTGFNIFYSINSCPNNCSGHGKCTTSVSVPSQVYCECDKYWKGEACDIPYCKANCGSPDHGYCDLTGEKLCVCNDSWQGPDCSLNVPSTESYWILPNVKPFSPSVGRASHKAVLHGKFMWVIGGYTFNYSSFQMVLNYNLESSIWNVGTPSRGPLQRYGHSLALYQENIFMYGGRIETNDGNVTDELWVFNIHSQSWSTKTPTVLGHGQQYAVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAIVQGGYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFARYLHSAVLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKILPKPNLHRDVNRFGHSAVVINGSMYIFGGFSSVLLNDILVYKPPNCKAFRDEELCKNAGPGIKCVWNKNHCESWESGNTNNILRAKCPPKTAASDDRCYRYADCASCTANTNGCQWCDDKKCISANSNCSMSVKNYTKCHVRNEQICNKLTSCKSCSLNLNCQWDQRQQECQALPAHLCGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYTQQKVSPWVGLRKINISYWGWEDMSPFTNTTLQWLPGEPNDSGFCAYLERAAVAGLKANPCTSMANGLVCEKPVVSPNQNARPCKKPCSLRTSCSNCTSNGMECMWCSSTKRCVDSNAYIISFPYGQCLEWQTATCSPQNCSGLRTCGQCLEQPGCGWCNDPSNTGRGHCIEGSSRGPMKLIGMHHSEMVLDTNLCPKEKNYEWSFIQCPACQCNGHSTCINNNVCEQCKNLTTGKQCQDCMPGYYGDPTNGGQCTACTCSGHANICHLHTGKCFCTTKGIKGDQCQLCDSENRYVGNPLRGTCYYSLLIDYQFTFSLLQEDDRHHTAINFIANPEQSNKNLDISINASNNFNLNITWSVGSTAGTISGEETSIVSKNNIKEYRDSFSYEKFNFRSNPNITFYVYVSNFSWPIKIQIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKPIAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKASDSKDKTSGVRNRKHLSTRQGTCV
What is the function of this protein?
May play a role in melanocortin signaling pathways that regulate energy homeostasis.
What are the official names of this protein?
Attractin-like protein 1.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RS17_HALMA
Sequence: MALGLNVQEPEETCADQNCPFHGELSVRGQTLNGEVASTDMEKTVVVEREYDVKVPKYDRFMKRRSRVPAHAPDCLDLAVGDTVTIAECRPLSKTKSHVVVGVVADEQDGDA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17, HS14, HmaS17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: HEM3_SHESH
Sequence: MSQNVIRIATRKSPLALWQAEFVKAELEKFHEGLTVELLPMSTKGDIILDTPLAKVGGKGLFVKELEVAMLEDRADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNNYKNISELPQGAVVGTSSLRRQCQIRASRPDLVIRDLRGNVGTRLGKLDAGNYDAIILAAAGLKRLKLEERITSFISAEESLPANGQGAVGIECRINDERVKALLAPLEHTETRHRVIAERAMNTHLEGGCQVPIGAYAEIQDDTLTLRGLVGNPDGSHIIEATKVGSKTDAQAIGVALAEELLSKGAKAILDAVYIK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: METK_PROM3
Sequence: MSRYVFTSESVTEGHPDKICDQVSDAVLDALLAQDPSSRVACETVVNTGLCLITGEVTSNSQVDFIHLVRNVIREIGYSGARAGGFDATSCAVLVALDQQSPDIAQGVNEADDHSGDPLDKVGAGDQGIMFGYACDDTPELMPLPISLAHRLARQLAAVRHDGSLSYLLPDGKTQVSVVYENDRPVAIDTILISTQHTSEVEGISDENGIRERITQDLWTHVVEPATADLPLKPNREATRFLVNPTGKFVVGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARFVAKCLVAAGLAQRAEVQLSYAIGVAKPVSILVESFGTGKVTNDELTALVQDHFDLRPGAIIEQFKLRQLPQQRGGRFYQDTAAYGHFGRPDLNLPWEDVTDKASTLLQAEAQQQKQGSSL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STML2_BOVIN
Sequence: MLARAARGTGALLLKGSVQASARAPRRASSGLPRNTVVLFVPQQEAWVVERMGRFHRILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMKMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTILLPSNPGDVTSMVAQAMGVYGALTKAPIPEAQDSVSSRSSRDVRSTDASLDEELDRVKLS
What is the function of this protein?
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria.  Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes.  Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress.  May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria.  Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria.  May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity).
What are the official names of this protein?
Stomatin-like protein 2, mitochondrial, SLP-2.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Mitochondrion. Mitochondrion inner membrane; Lipid-anchor. Mitochondrion intermembrane space. Membrane raft. Cytoplasm, cytoskeleton. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells.
Protein: IRS2B_XENLA
Sequence: MAGVLCPTEEDRSIRAAVRMLPPQPCPDESGGYRRMSGPTLSQVQEEPAAETPQPPAPASTAEDDVRKRGYLRKQKHGHKRYFVLRSQSHLGPARLEYYDNEKKFRSGQRSGCHPKRVIPLYLCFTVSRRADAKNKHLVALYTKDEYFAMAAENEQEQDGWYQALSELINESKGACLDTEELEENYGTLRPGTVFKEVWQVNVKPRGLGQAKNLSGVYRLCLSSKAVHLVKLNSDVACVHLLLMNIRRCGHSENYFFIEVGRSSSTGAGELWMQVDDCVVAQHMHETFLDTMKALKAYSEFRPRSKSQSSGTNPISFITTRRYLGNLPPSQTGLQQRRARTETVVGTPPSAKNNSFRFRTSSEGEGTMTRPFRSVTGSLSHLNTARINLGKQEGVGRYVRAPFNSGYHSRSASLPVSHFPSATSPISVCSSNGHGSASETLTRPSSSSVCGSPSDGGFISSDEYGSSPGDLRYFRVRSNTPDSLGNTPPIQEENTLSDYMSMSAHSQPDSRDDYMEADKCFRKRTYSLTKPTNAASQQKSQTAVSLDEDSEETNKQFAYAESPKLKDSSHVEDYSNGVIDSVCNHSRRKASDDGYMPMMPSNSYDSDYLPMAPKSVSAPKQINSCPSQVDSKGYMMMFPVNGSPVKNVFGGAATKSNIEKLSNGGYMDMSYGNSIKQVHDSSLNNNSRGLSSYFSLPRSFKSLTKQTSDHSEYVPMSSPGKLLHLGAENGVDACTNGADHNVAKTELKSPSSTLDQQVKRPTKLMLGIRGSNTIPRMFDHSASAEPTSPGEYINIDFSDKASSTPCSLSAEGSPSSLGSSCDHRHSPLSDYMSVDIDVQSPKATADLCDSLTDISPYACTVVSRMQPNAEYAKLPCGTACVSKTDNRIDDYTTMTFNMAMTPPRSFAGETENGTKVDSPSSIVNRLCIGDLTSLNGGFSLPNPLPEPMAGPKVIRADSQGRRRHSSETFSSASTVTTSSSCFTESSKRHSSASFDNVWLKSDENCCEQENKMSRNCSTGFQNGLNYIALSMHDGVCEPTSPACHQHQNGSRILENGGYVSIDFTRSDCLKCPSSRKD
What is the function of this protein?
Potentiates insulin signaling.
What are the official names of this protein?
Insulin receptor substrate 2-B, IRS-2-B.
Protein: CASD1_HUMAN
Sequence: MAALAYNLGKREINHYFSVRSAKVLALVAVLLLAACHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKNCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKTASVKVDFLWHPEVNGSMKQCIKVWTEDSIAKPHVIVAGAATWSIKIHNGSSEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRNSKSNVKMFSVSKLIAQETIMESLDGLHLPESSRETTAMILMNVYCNKILKPVDGSCCQPRPPVTLIQKLAACFFTLSIIGYLIFYIIHRNAHRKNKPCTDLESGEEKKNIINTPVSSLEILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFGIYRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQIIQKKANGNCFWHFGLLLKLGFLLLFICFLAYSQGAFEKIFSLWPLSKCFELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGKGEPLFSNKISNFLLFISVVSFLTYSIWASSCKNKAECNELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRLACIAAFFCGLLILSSIQDKSKH
What is the function of this protein?
O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids (PubMed:20947662, PubMed:26169044).  Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition (PubMed:20947662, PubMed:26169044).
What are the official names of this protein?
N-acetylneuraminate 9-O-acetyltransferase, CAS1 domain-containing protein 1, Sialate O-acetyltransferase, SOAT.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. CASD1 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: SECB_THISH
Sequence: MTDSQQPGAATEQPKTEFALQKFYLKDVSLECPRSPQVFTGEWKPETNVQLNSQARPLDDQGLFEVELTLTVTTKSGGEVAYLVEVKQAGVFLARGFPKEQMGHLLAAYCPTTLFPFAREAVTDLVSKAGFPQMLLAPVNFDALYAQQLAQNHAGKAGEESAPAGASH
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NNRD_BORPE
Sequence: MDTPTSSSLPAIERQHLPALFAARPTDAHKGSCGTLGVIGGGPGMVGAALLAARAGLKVGAGKVLVGLVADTPPLPCDPMQPELMLRDFRGLLEAGLGIDAWTAGCGCGMDALAANALSELFQLRGDAALVLDADGLNLLAAGAVQARWGDAPVVLTPHPAEAGRLLGLSTEAVQADRPGAARALAARYGAWIVLKGAGSIVCDPAGACRINRTGNPGLATAGTGDVLAGILGSLLAQRIAPEQAVPGAVWLHGAAADALVTHGVGPIGLTAGELADSARRLRNSRA
What is the function of this protein?
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP.  Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
What are the official names of this protein?
ADP-dependent (S)-NAD(P)H-hydrate dehydratase, ADP-dependent NAD(P)HX dehydratase.
What is the protein family that this protein belongs to?
Belongs to the NnrD/CARKD family.
Protein: DER_MYCBO
Sequence: MTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGVTRDRVCYDALWTGRRFVVQDTGGWEPNAKGLQRLVAEQASVAMRTADAVILVVDAGVGATAADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLGLGEPHAISAMHGRGVADLLDGVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDSLIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDSAEVAIVLIDASQPLTEQDLRVISMVIEAGRALVLAYNKWDLVDEDRRELLQREIDRELVQVRWAQRVNISAKTGRAVHKLVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGGKQPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKRAGKRR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: DEOC_BOVIN
Sequence: MSAHQQGTELDLSWISKIQVNKPAVLRRAEQIQARRPVKKEWQAAWLLKAVTCIDLTTLSGDDTASNIQRLCYKAKYPIREDLLKALNMHDKGITTAAVCVYPARVCDAVRALKAAGCDIPVASVATGFPAAQTHLKTRLEEIRLAVEDGATEIDVVINRTLVLTGQWKALYDEIRQFRKACGEAHLKTILATGELGSLTNVYKASMIAMMAGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKVGFKPAGGIRSAKDSLVWLSLIKEELGDEWMKPELFRIGASTLLADIERQIYHHVTGRYAAYHDLPMS
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.  Participates in stress granule (SG) assembly.  May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic granule. Nucleus. Note=Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation.
Protein: ZRAP_SALTY
Sequence: MKRNNKSAIALIALSLLALSSGAAFAGHHWGNNDGMWQQGGSPLTTEQQATAQKIYDDYYTQTSALRQQLISKRYEYNALLTASSPDTAKINAVAKEMESLGQKLDEQRVKRDVAMAQAGIPRGAGMGYGGCGGYGGGYHRGGGHMGMGNW
What is the function of this protein?
Binds zinc.  Could be an important component of the zinc-balancing mechanism (By similarity).
What are the official names of this protein?
Zinc resistance-associated protein.
What is the protein family that this protein belongs to?
Belongs to the ZraP family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CP2G1_RAT
Sequence: MALGGAFSIFMTLCLSCLLILIAWKRTSRGGKLPPGPTPIPFLGNLLQVRIDATFQSFLKLQKKYGSVFTVYFGPRPVVILCGHEAVKEALVDQADDFSGRGEMPTLEKNFQGYGLALSNGERWKILRRFSLTVLRNFGMGKRSIEERIQEEAGYLLEELHKVKGAPIDPTFYLSRTVSNVICSVVFGKRFDYEDQRFRSLMKMINESFVEMSMPWAQLYDMYWGVIQYFPGRHNRLYNLIEELKDFIASRVKINEASFDPSNPRDFIDCFLIKMYQDKSDPHSEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKYPEVEAKIHEEINQVIGTHRTPRVDDRAKMPYTDAVIHEIQRLTDIVPLGVPHNVIRDTHFRGYFLPKGTDVYPLIGSVLKDPKYFRYPEAFYPQHFLDEQGRFKKNDAFVAFSSGKRICVGEALARMELFLYFTSILQRFSLRSLVPPADIDIAHKISGFGNIPPTYELCFMAR
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  This isozyme seems to be implicated in olfaction.
What are the official names of this protein?
Cytochrome P450 2G1, CYPIIG1, Cytochrome P450 olfactive, Cytochrome P450-OLF1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: RECR_BIFLO
Sequence: MALAYDGAIQRLIDAFGRLPGIGPKGAQRIAFYMLSAPEDEARDLAEAIEEVKAKIRFCDICGNVCESSPCPVCADPRRDRSVICVVEEPKDVMSIERTREYHGLYHVLGGAINPMANVGPADLRIPGLLKRLEGDEVKEVIMALDPNIEGEATTSYLTQLLRPVGVKVTRLASGLPVGSDLEYADEITLGRALAGRREA
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: REX_OENOB
Sequence: MTADTQIPRATAQRLPIYYYYLSSLHEAGIKRINSTEISEAIKFDAATVRRDFSYFGALGKRGFGYDVSALLDFFSKVLSQDKLNKVAVVGTGNLGQALMKYNFVHSSNIQIVMGFDVDPKKKELKIDNEKGETIPVYSIGDLKSELNKENVTIAILTVPGKSAQEVTDQLVDAGIKGILNFSPIRITVPNSVRVQNVDLTTGMQTLIYFVDNFENIKSAK
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGRB_SALHS
Sequence: MKKFRWVVLGIVVVVCLLLWAQVFNIMCDQDVQFFSGICAINKFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: YN82_YEAST
Sequence: MVFTSSESSSLLSSLKMTCSMVSMNSLEQISLIKGVPPFFTHILVSFQEDNWVFGLSAVLRILFFIQRIESLGFTLLDLNTSEISNAMGRSRSPLGMLSLVACSINASNSLGVLTDILFLVLYSLLIHLSKKKS
What are the official names of this protein?
Putative uncharacterized protein YNR005C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GBRA2_PONAB
Sequence: MKTKLNIYNMQLLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity).  The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).  The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Cell projection, dendrite.