PharMolix/UniProtQA huggingface dataset:
Protein: HEM6_PSEA7
Sequence: MTDRIAAVKTYLLDLQDRICAALEAEDGKARFAEDAWERPAGGGGRTRVIGDGALIEKGGVNFSHVFGDSLPPSASAHRPELAGRGFQALGVSLVIHPENPHVPTSHANVRFFCAEKAGEEPVWWFGGGFDLTPYYASEEDCVHWHRVARDACAPFGADVYPRYKEWCDRYFHLKHRNEPRGIGGLFFDDLNQWDFDTCFAFIRAIGDAYIDAYLPIVQRRKHTPFDERQREFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSLPPQVRWGYDWKPEPGSEEARLTEYFLTDRDWLAGQP
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GBRA5_RAT
Sequence: MDNGMLSRFIMTKTLLVFCISMTLSSHFGFSQMPTSSVQDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKERELILNKSTNAFTTGKLTHPPNIPKEQLPGGTGNAVGTASIRASEEKTSESKKTYNSISKIDKMSRIVFPILFGTFNLVYWATYLNREPVIKGATSPK
What is the function of this protein?
Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain.  May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse.
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit alpha-5, GABA(A) receptor subunit alpha-5.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: NS1_I49A0
Sequence: MDSNTITSFQVDCYLWHIRKLLSMRDMCDAPFDDRLRRDQKALKGRGSTLGLDLRVATMEGKKIVEDILESETDENLKIAIASSPAPRYIMDMSIEEISREWYMLMPRQKVTGGLMVKMDQAIMGKRIILKANFSVLFDQLETLVSLRAFTEDGAIVAVISPIPSMPGHSTEDVKNAIGILIGGLEWNDNSIRASENIQRFAWGIRDEDGGPPLPPKQKRYMARRIESEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: PIMT1_CUPNH
Sequence: MTVGSLPAPLVKPSAPRPLLPILVAAIALALPCSITAADDALAPQRADMVREIAAVAAAAAAQSGRHAIDPRVMAVMGQVPRHEFVPDAQKPHAYENRPLPIGHGQTISQPYIVALMTDLMMVKPGDTVLEIGTGSGYQAAVLTGLARAVYTIEIIEPLGRHACDRLKRLAYRQVACKVGDGYYGWDEHAPYDAIVVTAAASHVPPPLIRQLKPGGRMVIPVGAQFLTQYLLLVEKSEDGTVSTRQILPVRFVPLVGKH
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase 1, L-isoaspartyl protein carboxyl methyltransferase 1, Protein L-isoaspartyl methyltransferase 1, Protein-beta-aspartate methyltransferase 1, PIMT 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAHS2_HYPEX
Sequence: MARLFVAVALFGVVAFAAAEKEWTGKTWLGSWASTDRAENWEAFVDALGLPSDQYPREVQRTIHTIYKQGDKYHHEVSIPSKNFKKAIEYTLGTETDVQHGPHTIKLKYTEDGEKLVADVQIPSKNKQIHDIYEVQGDTLTKTYKVGDVVAKRWFTREANPTA
What is the function of this protein?
Secreted heat soluble protein acting as a molecular shield in water-deficient condition (PubMed:28306513).  Tardigrade-specific intrinsically disordered proteins (TDPs) are essential for desiccation tolerance by forming non-crystalline amorphous solids upon desiccation, and this vitrified state mirrors their protective capabilities (PubMed:28306513).
What are the official names of this protein?
Secretory-abundant heat soluble protein 53582, SAHS 53582, Secretory-abundant heat soluble protein b, SAHS-b, Tardigrade-specific intrinsically disordered protein SAHS 53582, TDP SAHS 53582.
What is the protein family that this protein belongs to?
Belongs to the Secretory-abundant heat soluble protein (SAHS) family.
Protein: Y1520_BACCR
Sequence: MNTPVSVNEKKDFVKWFLNNYQLKQRECVWILNYLMSHDQLMHKVHFVEHAKYCPRGLVMSANCVKDTPFHFFKQNVMTTDAEKSFHDIRLNRDEDIYIQLNFKSSFQNANYVAVLEENPYLPKHIEVNEKDRLLAERFLEESVFSFRRERLLKQIDEALDKQDKEAFHRLTAELKTL
What are the official names of this protein?
UPF0302 protein BC_1520.
What is the protein family that this protein belongs to?
Belongs to the UPF0302 family.
Protein: EXOI_RHIME
Sequence: MTRIKSAVAAGGRRAPHSARLGSASTRTIGAVLAALLMTHDAGAAEPIIGQASVIDGDTIEIAGERVQLNSVDAPEEWQVCLDERGADYRCGKESASALDAFLSASRPTRCEFAGRDRYGRFVGTCFRADGKDVNRWLIESGNAVDRDTDNKGLYASAQQTAKSNGAGIWRAQPEHACAARVGRVNRKPSC
What are the official names of this protein?
Succinoglycan biosynthesis protein ExoI.
Protein: RL24_STRGG
Sequence: MKIKKGDLVQVITGKDKGKQGKVIVAYPAQDRVLVEGVNRVKKHTKAGQTARGSQTGGIVTTEAPIHVSNVQLVVEKDGNKVVTRVGYRFDDEGNKIRVAKRTGEDI
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PSA_SALTO
Sequence: MAMQFYASPEQIMRDRSELARKGIARGRSAVVLSYAGGVLFVAENLSSALHKVGEIYDRIGFAAVGRYNEFENLRRAGVRMADLNGLSYDRRDVTGRALANSFAQTLGAIFTEQSKPFEVEICVAQVGVTAEDDELYRLTYDGSVNDEPGRMAMGGQAEAIAGALKSNHRSDMSLGDAVKVAVRALGSVGGEGGAARTIAADQLEVAILDRHRDGRTFRRVTGAALTALLDDGAAAASTDAPAAAADSADVEERPDSEAP
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PrcA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H11R_CHICK
Sequence: MAETAPAAAPAAAPAPAAKAAAKKPKKAAGGAKARKPAGPSVTELITKAVSASKERKGLSLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFRLSKKPGEGLEKAPKKKASAAKPKKAAAKKPAAAAKKPKKAVAVKKSPKKAKKPAASATKKSVKSPKKAAKPKKAVAAKSPAKAKAVKPKAAKPKAAKPKAAKAKKAAAKKK
What is the function of this protein?
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
What are the official names of this protein?
Histone H1.11R.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RS18_COPPD
Sequence: MPVQRKRRIKLCPLCADGVREVDYKDVNRLRRFTSDRGKILPRRVTGVCAFHQRSLSRAIKRAREMALLPYVMQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: NDK_NITEC
Sequence: MVVERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAARMAHLSRVEAENFYAIHRERPFFKDLVEFMISGPVMIQVLEGENAIAKNRELMGATDPKKAEKGTIRADFAENIDANAVHGSDAPETAAVEIACFFPSLEVYSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBI_SORBI
Sequence: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGREE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: FTSW_ALLVD
Sequence: MTAAAPSKPLPRTPRVRQAYPLDYPLLLCALGLLAFGWVMVTSASMSIAEACCQNPFHYSIRHAIALGLALMLGLMAYSVPSHWWERHGVWLFLASALVLILVLIPGIGRTVNGATRWIPLGPLNVQPSEFVKLFAILYVAGYLVRHADKVVNQLSGFIRPLILIGAAALLILMQPDFGTTAVMLATVMGMLFLGGASLLPFIVLLAIVGAGLVTLVIFSPYRLERVVSFLNPWEDPFNSGYQLSQALIAFGRGEWFGVGLGNGIQKQYFLPEAHTDFLPSVIGEELGLAGMLVLIAAFVFLSWRAMSIGVRAEALKRPFESYVAQGIGLWIGLQSFVNLGVNVGILPTKGLTLPFMSYGSNSLMVGCMAVAILLRIDVMLRRVESEAKFKRGTPWSRA
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell division.
What are the official names of this protein?
Probable peptidoglycan glycosyltransferase FtsW, PGT, Cell division protein FtsW, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. FtsW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Protein: DCTA_ECO7I
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDVLNNRAPDGKTHELSS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL2_PARMW
Sequence: MAIRNFRPYTPGTRTRVVTDFSEVTGRKPERSLVVSKHRRKGRNNRGVITCRHRGGGHKRLYRVVDFRRNKHGITAKVAAIHYDPHRNARLALLFYADGEKRYILAPAGVQVGQTVVSGPDAPIENGNAMPLSAVPLGSSVHCVELYAGRGGQMVRTAGASAQVMAKEGDYVALKLPSTEVRLVRRECYATLGEVGNSEVRNTSLGKAGRRRWLGRRPQVRGSVMNPCDHPHGGGEGRAPIGRSGPVTPWGKPALGLKTRKRNKPSNRYVLRKRRKTSKRSRGGRDS
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PRTD_STRGR
Sequence: MCVSRRRNSGRPILRVRAPHLLRARPHRRSKLKHRRISRKRATLAGSAVVALVAAGFTFQTANASDDVPAFGAKTLSADAAGKLATTLDRDLGADAAGSYYDATAKTLVVNVVDEAGAEQVRQAGGKARIVENSLAELKSARGTLTEKATIPGTSWAVDPVSNKVLVTADSTVDGAAWKKLSAVVEGLGGKAELNRTAGEFTPLIAGGDAIWGSGSRCSLGFNVVKGGEPYFLTAGHCTESVTSWSDTQGGSEIGANEGSSFPENDYGLVKYTSDTAHPSEVNLYDGSTQAITQAGDATVGQAVTRSGSTTQVHDGEVTALDATVNYGNGDIVNGLIQTTVCAEPGDSGGALFAGDTALGLTSGGSGDCSSGGTTFFQPVPEALAAYGAEIG
What is the function of this protein?
Has a primary specificity for large aliphatic or aromatic amino acids.
What are the official names of this protein?
Streptogrisin-D, SGPD, Serine protease D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: TIDC1_XENLA
Sequence: MAQSDPPKSPDPPLPTSIRNPQTPESGWDRIRELFQPNEQGHYPEEVGSIVKSAVTGALLGGIYGGLPAARHSKERYIQQSQAQIYQHRVEAVRSAHNAALRGFIRYGWRWGWRVAAFVTIFNSVSTGLTVYRDKLALSHYAAAGAVTGGLFRLNLGLVGLLSGSLIGAALGVPAGALISGLQSISGESIREKKRRERQELYENKVQEWSARLQVTDEVLEEMETSQQDPLEQQVEKIQELLQLPRNPAVSPKEGR
What is the function of this protein?
Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).  Participates in constructing the membrane arm of complex I (By similarity).
What are the official names of this protein?
Complex I assembly factor TIMMDC1, mitochondrial, Translocase of inner mitochondrial membrane domain-containing protein 1, TIMM domain containing-protein 1.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: RL1_PROM1
Sequence: MKNFSKRMTTLLSKVEERSYSPIEAIKLVKENANAKFDETIEAHIRLGIDPKYTDQQLRTTVALPSGTGQKIRIAVVTRGEKVNEATKAGADLAGEEDLVDSINKGEMNFDLLISTPDMMPKVAKLGRVLGPRGLMPNPKAGTVTTDLEGAIKEFKAGKLEFRADKAGIVHVRFGKASFSEEALLENLKTLQTTIEKNKPSGAKGKFWRSFFITSTMGPSVEVDINELQDLQKEK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: DOG1_YEAST
Sequence: MAEFSADLCLFDLDGTIVSTTVAAEKAWTKLCYEYGVDPSELFKHSHGARTQEVLRRFFPKLDDTDNKGVLALEKDIAHSYLDTVSLIPGAENLLLSLDVDTETQKKLPERKWAIVTSGSPYLAFSWFETILKNVGKPKVFITGFDVKNGKPDPEGYSRARDLLRQDLQLTGKQDLKYVVFEDAPVGIKAGKAMGAITVGITSSYDKSVLFDAGADYVVCDLTQVSVVKNNENGIVIQVNNPLTRA
What is the function of this protein?
Phosphatase that is active on 2-deoxy-D-glucose 6-phosphate (2-DOG-6P), as well as on fructose-1-P.
What are the official names of this protein?
2-deoxyglucose-6-phosphate phosphatase 1, 2-DOG-6-P 1, 2-deoxyglucose-6-phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.
Protein: CLD4_CHLAE
Sequence: MASMGLQVTGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFLLAGLLVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV
What is the function of this protein?
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney.  Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts.  Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
What are the official names of this protein?
Claudin-4, Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=CLDN4 is required for tight junction localization in the kidney.
Protein: ABCD1_MOUSE
Sequence: MPVLSTPRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPARGPQVPAGEPTQEASGATATKAGMNRVFLQRLLALLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERTEAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVKHCRFKRTGDLEEAQAGPGVMVQSGVHVEGPLKIQGQVVDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQGRLQELRQILGEAAAPVQPLVPGVPT
What is the function of this protein?
ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen.  Has fatty acyl-CoA thioesterase (ACOT) and ATPase activities.  Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (By similarity).  Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:9126326, PubMed:9418970, PubMed:9256488, PubMed:18854420, PubMed:23123468, PubMed:23604518, PubMed:25255441, PubMed:25583114, PubMed:26108493).  Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance (PubMed:11875044, PubMed:15489218, PubMed:26108493).  Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization (PubMed:18344354, PubMed:22521832, PubMed:23604518, PubMed:25583114).  And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (PubMed:18723473).
What are the official names of this protein?
ATP-binding cassette sub-family D member 1, Adrenoleukodystrophy protein, ALDP.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VG27_ICHVA
Sequence: MASITGQLSPMYINNVNTRSAYQPYIPVLERFDPRDLEVPKGVFVPLSGAMYFPTVHGMSLPQRRPLGLVQTGGLMSEPMTVDVVPGKLYTVLNTGCDTLRVGDHFMVQFPQPEDTDAQLRASKKPGTRRICNAASFNRMLPLWGGFMAVKKIDPIVPRELMHQLTRDVVTARSSELLYGLAGVYDLVEKTSAAARGVFKDIAEKKAVTKEEVVAAMTADQVDIFRKIVDEFSTMLNCVNFATIGMYHSSTLANPTPSLSQNQVWCNTDGVTEPGLQFHAFIKQFSGV
What are the official names of this protein?
Uncharacterized protein ORF27.
Protein: RUVB_PSYCK
Sequence: MAKTMMQDRLINPLEGAADAPDANIRPALLAEYIGQPVVREQMEVFIQAARARDEALDHTLIFGPPGLGKTTLANIIAREMGGNLRSTSGPVLERAGDLAAMLTNLEAGDVLFIDEIHRLSPVIEEILYPAMEDFQLDIMIGEGPAARSIKLDLPPFTLVAATTRAGLLTSPLRDRFGIVQRLEFYNIADLTTIVSRAARLMRVPMSEDGAVEIARRARGTPRIANRLLRRVRDYAQVRGDGSINGAIAGSALDMLAVDRRGLDHLDRRYIEILHERFDGGPAGVEAVAAAMAEDRGTLEDVIEPYLIQQGYVLRTARGRVLTQMAIDQML
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SPXH_STAEQ
Sequence: MAEELRIMENKSREDTNLSPVSKIEIYSFFDPFSKDCFKLSAILSKLRIEYNKYIKVRHILNPSLKVLTKCQAQSTSDFDNIALAYKAAELQGRIRAERFIHLMQNEIIPKRDIITEDMISDCINNAGIDYQVFKEDLQKDKLTDSLKVDLHIAREMEIEQAPSLVFFSENVHEEGLKVEGLYPYHIYTYIINELMGQPIEKNLPPKLEYYIQKKQLVTMEELLTIYEWPEKLLNKELKKLTLQQKVEKLQYPEGEFWKSKMPQC
What is the function of this protein?
Adapter protein required for efficient degradation of Spx by ClpXP under non-stress conditions.  Interaction with Spx stabilizes Spx and exposes the C-terminus of Spx for recognition and proteolysis by ClpXP.
What are the official names of this protein?
ClpXP adapter protein SpxH.
What is the protein family that this protein belongs to?
Belongs to the SpxH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F169B_HUMAN
Sequence: MKVQSFGERVVLFILNAIIFGRLERNLDDDDMFFLPHSVKEQAKILWRRGAAVGFYTTKMKGRLCGDGTGACYLLPVFDTVFIRRKHWHRGLGTAMLRDFCETFPEDEALGVSCSMSPAMYQAHPGNSEDVSRHARTSQNDRPRQPAPGDGSKERMCGEELEDTKDDPECGVEEEDAGLAGQPPGKLTRSSP
What are the official names of this protein?
Protein FAM169BP, FAM169BP pseudogene.
What is the protein family that this protein belongs to?
Belongs to the FAM169 family.
Protein: MX_CHICK
Sequence: MNNPWSNFSSAFGCPIQIPKQNSNVPPSLPVPVGVFGVPLRSGCSNQMAFCAPELTDRKPEHEQKVSKRLNDREEDKDEAAACSLDNQYDRKIQPCIDLVDSLRKLDIGNDLMLPAIAVIGDRNSGKSSVLEALSGVALPRDKGVITRCPLELKLKKMTAPQEWKGVIYYRNTEIQLQNASEVKKAIRKAQDIVAGTNGSISGELISLEIWSPDVPDLTLIDLPGIAREAVGNQPQDNGQQIKTLLKKYIGCKETIIVVVVPCNVDIATTEALKMAQEVDPTGERTLGVLTKPDLVNEGTEETVLKIIQNEVIPLRKGYMIVKCYGQMDFCNELSFTSAIQQEREFFETHKHFSTLLDENKATIPHLANKLTDELVGRIIKTLPAIEKQVHDALQQAKKELQKYTQSTHPTVSDKTIFLVGLIKAFNEDISQTMHGKESWFGNEIRLFPKIRREFRTWGVKLLESSAKVEEIVCSKLPKYEDQYRGREFPDFISYWTFEDIIKEQITKLEEPAVAMLNKVIYMVEEKFLQLANKRFANFQNLNNAAQARIGCISDRQATTAKNCILTQFKMERIIYCQDNIYADDLKAARAEGISKDTKIKDLAFGCASRQCPSFALEMVSHVKAYFTGASKRLSNQIPLIILSTVLHDFGNYLQTSMLHLLQGKEEINYLLQEDHEAANQQKLLTSRISHLNKAYQYLVDFKSL
What is the function of this protein?
Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus.
What are the official names of this protein?
Interferon-induced GTP-binding protein Mx, Interferon-inducible Mx protein.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Cytoplasm.