PharMolix/UniProtQA huggingface dataset:
Protein: DTD_RIPO1
Sequence: MRVIIQRVKGSSVRVNGEIVGQISRGLNLLVGIGNNDTESELDWMTRKCLELRLFPAEEGGDRWEKSVQEIQGELLVISQFTLYGDCRKGRRPSFSDSASPSIAKTLYDQFVAQLKDSGLKVETGIFGAMMQVTIDNDGPVTLLLER
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_RICCN
Sequence: MESFEKLEKLLSYSFKNKELLIEALSHPSLRQHHEYKDDKDYERLEFLGDAVLNLVITEILFRNFANYNEGNLAKIRSYLVCKETICMVGAKLTLKNYIIMTHGEEVAGGRDNLNNIENATEALIAAIYLDSNIETTHDIIENLWAEFIKVQNLTDYDPKTALQEWAQASDHHLPIYRLIKREGASHSSTFTVLVKVKDYEQTGTGHTIKEAEKNAARSLLHRLKND
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATP_ECO27
Sequence: MKYQQLENLESGWKWKYLVKKHREGELITRYIEASAAQEAVDELLSLENEPVLVNGWIDKHMNPELVNRMKQTIRARRKRHFNAEHQHTRKKSIDLEFIVWQRLAGLAQRRGKTLSETIVQLIEDAENKEKYANKMSSLKQDLQALLGKE
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAL14_MOUSE
Sequence: MKTEDDEMEYEASKEETVSEDKDFDDGIDYRTVIKENIFTMWYKTSLHGEFATLNCVITPKDQNLLQHIFDEDIQTSEAPQTVVLQGAAGIGKTTLLKKAVLEWADGNLYQQFTHVFYLNGKEISQVKEKSFAQLISKHWPSSEGPIEQVLSKPSSLLFIIDSFDELDFSFEEPQFALCKDWTQISPVSFLISSLLRKVMLPESYLLVATRSTAWKRLVPLLQKPQRVKLSGLSKNARMDYIHHLLKDKAWATSAIYSLRMNWRLFHMCHVCHMCQMICAVLKGQVEKGGRVEETCKTSTALFTYYICSLFPRIPVGCVTLPNETLLRSLCKAAVEGIWTMKHVLYQQNLRKHELTREDILLFLDAKVLQQDTEYENCYMFTHLHVQEFFAALFYLLRENLEEQDYPSEPFENLYLLLESNHIHDPHLEQMKCFLFGLLNKDRVRQLEETFNLTISMEVREELLACLEGLEKDDSSLSQLRFQDLLHCIYETQDQEFITQALMYFQKIIVRVDEEPQLRIYSFCLKHCHTLKTMRLTARADLKNMLDTAEMCLEGAAVQVIHYWQDLFSVLHTNESLIEMDLYESRLDESLMKILNEELSHPKCKLQKLIFRAVDFLNGCQDFTFLASNKKVTHLDLKETDLGVNGLKTLCEALKCKGCKLRVLRLASCDLNVARCQKLSNALQTNRSLVFLNLSLNNLSNDGVKSLCEVLENPNSSLERLALASCGLTKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQCTLQSLVLRSCSFTPIGSEHLSTALLHNRSLVHLDLGQNKLADNGVKLLCHSLQQPHCNLQELELMSCVLTSKACGDLASVLVNNSNLWSLDLGHNILDDAGLNILCDALRNPNCHVQRLGLENCGLTPGCCQDLLGILSNNKSVIQMNLMKNALDHESIKNLCKVLRSPTCKMEFLALDKKEILKKKIKKFLVDVRINNPHLVIGPECPNTESGCWWNYF
What is the function of this protein?
May be involved in inflammation and spermatogenesis.
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 14, NALP-iota, Germ cell specific leucine-rich repeat NTPase.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDC15_YEAST
Sequence: MNSMADTDRVNLTPIQRASEKSVQYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWINSTENVKVDKLNKFKEDFTDADYHWDADFQEEKLNISPSKFSLAAAPAAWAENNQELDLMPPTESQLLSQLKSSSKPLTDLHVLFSVCSLENIADTIIECLSRTTVDKRLITAFGSIFVYDTQHNHSRLRLKFIAMGGIPLIIKFEHLAKEFVIDYPQTLIECGIMYPPNFASLKTPKYILELVYRFYDLTSTAFWCRWCFKHLDISLLLNNIHERRAQSILLKLSSYAPWSFEKILPSLIDSKLKKKILISPQITYVVFKSINYMITTNDDKIHKSAIPSSSSLPLSSSPTRNSPVNSVQSPSRSPVHSLMATRPSSPMRHKSISNFPHLTISSKSRLLIELPEGFFTWLTSFFVDMAQIKDLSVLKYFTKLCYLTVHINSTFLNDLLDNDAFFAFIRNIDTIIPFIDDAKTAAFIWKQITAICVEMSLDMDQMSASLFSTAMNFIRKKNNTSISGLEIILNCLHFTLRNVNDDVAPTVGSSESHSVFLIKVNNDAAIELPIDQLVDLFYALNDDDVNLSKLISIFTKICSLPGFENLTINIIFHPNFYEKIVSFFDTYFNSLLIQIDLLKFIKLIFSKSLLKLYDYTGQPDPIKQTEPNRRNKATVFKLRAILVQITEFLNNNWNKDVPKRNSNQVGGDSVLICQLCEDIRSLSKKGSLQKVSSVTAAIGSSPTKDERSNLRSSKDKSDGFSVPITTFQT
What is the function of this protein?
Protein kinase of the mitotic exit network (MEN) essential for late nuclear division in the mitotic cycle.  Promotes mitotic exit by phosphorylating DBF2 and directly switching on DBF2 kinase activity.  Involved in the localization of DBF2 and DBF20 to the neck which is necessary to undergo cytokinesis.  Plays a role in segregation of chromosomes during recovery from spindle checkpoint activation.  Required for spindle pole localization of CDK1 and inactivation of CDC2 kinase activity at the end of mitosis.  Required for spindle disassembly after meiosis II and plays a role in spore morphogenesis.
What are the official names of this protein?
Cell division control protein 15.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle pole. Bud neck. Note=Localizes to the spindle pole bodies at late anaphase and translocates to the cytoplasm upon DNA replication stress. Localization to SPBs depends on CDC5 and TEM1 and is inhibited by BUB2. Accumulates at the daughter SPB after anaphase onset when the daughter SPB begins to penetrate the bud neck. Not found in the mother SPD during early anaphase. As anaphase proceeds, continues to accumulate on the daughter SPB and also localizes to the mother SPB. At the end of telophase, a portion of CDC15 localizes at the mother-bud neck.
Protein: CBPM_SHIBS
Sequence: MANVTVTFTITEFCLHTGISEEELNEIVGLGVVEPREIQETTWVFDDHAAIVVQRAVRLRHELALDWPGIAVALTLMDDIAHLKQENRLLRQRLSRFVAHP
What is the function of this protein?
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA.  Together with CbpA, modulates the activity of the DnaK chaperone system.  Does not inhibit the co-chaperone activity of DnaJ.
What are the official names of this protein?
Chaperone modulatory protein CbpM.
What is the protein family that this protein belongs to?
Belongs to the CbpM family.
Protein: RLMN_PSET1
Sequence: MTEQKKINLLDLNREGMRELFASFGEKPFRSDQVMKWIYHFGVDNFDDMSNVNKKLKEKLKAECEIVAPEISVRQQAKDGTIKYALVLEGGQEVEAVWIPEKERATLCVSSQVGCALECTFCSTAQQGFNRNLKVSEIIGQVWRVAKDIGLDGHSEKRPVTNVVMMGMGEPLLNVKNVVPAMELMLDDWGFGLSKRRVTLSTSGVVPALDLLKEKIDVALAISLHAPDNALRDILVPVNKKYPIEEFLAACRRYIDGSKANKDVTVEYVMLNGINDSTDQAHALVQTLKGTPCKVNLIPFNPFPGNEYTRSSNSRIDRFSKVLQAAGITCIVRRPRGDDIDAACGQLAGDVVDRTKRLAKKKMRDDNAIAVNIHQA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_PORGI
Sequence: MLLPIYLYGHPVLRKVAEDITPDYPKLKELIANMTESMYHSDGIGLAAPQIGLPIRVLVIDADPLKEDYPECAGFKRVMINAHIEERGEDLCTEYEGCLSLPAIHEKVERPTSIRIRYVDEDFQPHEEVLQGFAARVVQHEYDHIDGKLFIDHISPIRKQLIKGKLQNIIKGKVRTSYRVVTAPTGKKR
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: PB2_I76A6
Sequence: MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMVPERNEQGQTLWSKMSDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKVYKTYFDKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDIDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAILRKATRRLVQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMVGVLPDMTPSTEMSMRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETHGTERLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKTTKRLTILGKDAGTLIEDPDESTSGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: MIAA_AFIC5
Sequence: MKAVLIAGPTASGKSALALALAEAAGGTVINTDSMQVYRDLRVLTARPTIEEEVCAPHRLYGHVDAAVNYSAGAWVNDAAAVLAEVHAEGRLPIFIGGTGLYFKALTRGLSDVPPVPDEVRQGVRARLDRDGPEALHEELARRDPQAAARLKPRDRVRIARALEVVEATGRPLADWHAHGLPPLLPAEGVTALFLAPDRAALYERIDRRFEVMAASGALAEAEALGRRGLDPLLPAMKAHGVPALIRHLAGELTREEAIAIGQIDTRHYAKRQFTWFRHQLPEFEWIAPNDARAWLGAKLGMTLP
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: MEND_SYNJB
Sequence: MTGENFVLPRRLDWRNLNTLWGSLLAETLSRLGCRLAVVSPGSRSAPLTYALAQHPNIEAIPVLDERSAAFFALGLAQQTRQPIPLVCTSGSAGAHFFPALIEAAESGWPLLVLTADRPPELRHCRAGQAIDQVKLYGHYPNWQAELALPSADPEALAYLRQTLVHAWERTLYPFPGPVHLNVPFRDPLAPIADGSTAPLLHLQEDPEFEKTFFRGVAPPCTGSSLQAVRSPFQTETVSFWQEWRGCERGVILAGPAQPADPQRYVEAVAHLATALGWPVLAEGLSPLRNYASLNPYLITTYDLILQRDRPQLWPEQVIQLGSLPTSKALRQTLAKVAPRVWRLDPRPDNGDPLHNPTTHLPFAVEEWVAGIPEAPAKRTTFLQGWLTAEAQIRAALDQAMTDLSEWFEGKVAWWLAHHLPPETPLFIANSTPVRDVEWFWPPNDRRIRPYFNRGTNGIDGILSTALGVAHGSHKRPTVLLTGDLAFLHDSSGLRLGQQVRGSLTILLINNQGGGIFELLPIAEVGRQGPDPPFEPYFATPQLVDLALLCQAHGIPHRRVESWQELAQALDPLPAQGVRVLEILTDRKADAQRRRDWFQQWSELPSKP
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: BIOF_METS4
Sequence: MPVPPTLSLDAFAAAKLAGLDAAGLRRRLVPTARTGGARAERDGRAVVSFSCNDYLGLATHPEVVAAAHAALDRYGAGSGGSRLVTGSHPILAELEAALAARKGHEAALVFGSGYLANLGVTPALVGAGDLILIDELGHSCMWAGTRLAGARALPFRHNDLGHLEDLLARERARARRALILTERVFSMDGDRAPVAEILGLARAFDAWTLVDDAHGLGVVGPDATAPLEMGTLSKALGSYGGYLCASRPVIDLLTSRARSFVYTTGLPPASAAAALAALRLIEAEPARAARPLALARRFTARLGLPEAQSAVVPVLVGEAEAALALSRALEARGFLVVAIRPPTVPPGTARLRVAFSAAHEEAEVDALAQALLDLGAAA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase, Alpha-oxoamine synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: PANC_PHOLL
Sequence: MLIVETVPILRREIRRWRQEGKRIALVPTMGNLHDGHMTLVDTAKGQADIVIVSIFVNPMQFNRPDDLAKYPRTLQEDCEKLHQHGVNLVFAPADKEIYPDGMEHQTYVDVPELSTMLEGASRPGHFRGVSTVVSKLFNLVQPDLTYFGEKDFQQLQLIRKMIADLAYDITLVSVPTVRDQNGLALSSRNNNLTADEHRIAPELSKIMRSIAEKMAQGERHTEQLLTQASSQLHEAGFVPDELFIRDAETLAPLNTESKKAVILMAAWLGQTRMIDNQQVDLTQ
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALBG_BACSU
Sequence: MKQSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVRLGLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAEDVKSLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILYLLFCMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSFIYKRFSYHSTASLDL
What is the function of this protein?
Involved in the production of the bacteriocin subtilosin.
What are the official names of this protein?
Antilisterial bacteriocin subtilosin biosynthesis protein AlbG.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACL6A_MOUSE
Sequence: MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGVVLERDDGSTMMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAKREKLTELMFEHYSIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELIPPYMIASKEAVREGSPANWKRKEKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAERLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSFTDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP
What is the function of this protein?
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).  Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.  Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix.  Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors.  During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.  The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.  As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).  The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.  The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523).  Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.  This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.  NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.  Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity).
What are the official names of this protein?
Actin-like protein 6A, 53 kDa BRG1-associated factor A, Actin-related protein Baf53a, BRG1-associated factor 53A, BAF53A.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ILVC_BURA4
Sequence: MNVFYDKDADLSLIKGKQVTIIGYGSQGHAHALNLKDSGVNVTVGLRKDGASWSKAENAGLSVKEVAEAVKGADVVMMLLPDEQIADVYAKEVHANIKQGAALAFAHGFNVHYGQVIPRADLDVIMIAPKAPGHTVRGTYSQGGGVPHLIAVAQNKSGAARDIALSYAAANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYEGGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLTDIQTGEYAKSFILENKAGAPTLQSRRRLTAEHQIEQVGAKLRAMMPWIAKNKLVDQTKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: INHA_MYCBO
Sequence: MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
What is the function of this protein?
Is the primary target of the first-line antitubercular drug isoniazid (INH) and of the second-line drug ethionamide (ETH) (PubMed:12406221).  Overexpressed inhA confers INH and ETH resistance to M. bovis (PubMed:12406221).  The mechanism of isoniazid action against InhA is covalent attachment of the activated form of the drug to the nicotinamide ring of NAD and binding of the INH-NAD adduct to the active site of InhA (By similarity).  Similarly, the ETH-NAD adduct binds InhA (By similarity).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR, Enoyl-ACP reductase, FAS-II enoyl-ACP reductase, NADH-dependent 2-trans-enoyl-ACP reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.
Protein: DHLE_BACCR
Sequence: MTLEIFEYLEKYDYEQVVFCQDKESGLKAIIAIHDTTLGPALGGTRMWTYDSEEAAIEDALRLAKGMTYKNAAAGLNLGGAKTVIIGDPRKDKSEAMFRALGRYIQGLNGRYITAEDVGTTVDDMDIIHEETDFVTGISPSFGSSGNPSPVTAYGVYRGMKAAAKEAFGTDNLEGKVIAVQGVGNVAYHLCKHLHAEGAKLIVTDINKEAVQRAVEEFGASAVEPNEIYGVECDIYAPCALGATVNDETIPQLKAKVIAGSANNQLKEDRHGDIIHEMGIVYAPDYVINAGGVINVADELYGYNRERALKRVESIYDTIAKVIEISKRDGIATYVAADRLAEERIASLKNSRSTYLRNGHDIISRR
What is the function of this protein?
Catalyzes the reversible deamination of L-leucine to 4-methyl-2-oxopentanoate.
What are the official names of this protein?
Leucine dehydrogenase, LeuDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: C71Z4_PASSA
Sequence: MDPAAIFLILAIPIASVYLLFYHKKRVNGLSSPPGPRGLPFIGHFYQIYKSECAHEYISNLSKQYGSLMTLHLGSVPALVVSSPKMAQEVLKTQDLVFCSRAQMTGSGKLSYNGLEMAFAPYGEHWRNVRKMCTLELFTQKRAQFNFRPVREDEVSRMVGRLSEAAAASEDVNAYECFTNFATSIISRVAFGKRYDEDNLGKEKFQRMVADIEAMFAAFFVSDFFPMFGWIDRLSGVKAVLDRNFNEMDTFYQELIDEHLKPDRPESLNGDLIDVMLKNKGSFLTMDSIKAILLNVFSGGIGTTGSALVFAMTALLRNQRVMKKAQEEVRSVIGKKEIVDEDDIQKLPYLRAVVKETLRLYPPGPLLIPRVAMESCVLGEDEDHMYMIKPNTIVYVNTWGIGRDPKYWKNPLEFMPERFFERPDLNYTGQQFEYLPFGSGRRICAGIIIGQNNVEVGLANLLYSFDWEPPTGKTFEDIDDQPCNGLTLAKKNPLYIRPKIYVHP
What is the function of this protein?
Involved in the biosynthesis of coumarins and furanocoumarins (FCs), natural products required for defense responses against attacks by predators with potential medical and agroindustrial usages such as anticoagulant, rodenticide and artificial vanilla substitutes (PubMed:29971079).  Catalyzes the conversion of psoralen into xanthotoxol and of 6-methoxycoumarin into scopoletin (PubMed:29971079).  Can also convert with a lower efficiency scopoletin into fraxetin and 7-methoxycoumarin into daphnetin-7-methylether, and use 7-methoxy-3-methylcoumarin as substrate (PubMed:29971079).
What are the official names of this protein?
Xanthotoxol synthase, Cytochrome P450 CYP71AZ4, Fraxetin synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein.
Protein: FBID_CHLAA
Sequence: MIGIVIPIKRLHLAKSRLIDLLDPADRQQLVVTMVRHVITTARQAVSYLSIPARIWLVSPEPTLATDSEGIEWLPDNQEELNAALTEARQRIQAAGVQIMMVLAGDLPFVTVRDLILLSEALTDNDVVVAPDQHGQGTNALGLHLPSQLPFGFGPDSAGYHLRTAARLGLRASLISTPTLAFDLDDGERLQQYYRCIASCDNFAR
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
Phosphoenolpyruvate guanylyltransferase, PEP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.