PharMolix/UniProtQA huggingface dataset:
Protein: DAD1_YEAST
Sequence: MMASTSNDEEKLISTTDKYFIEQRNIVLQEINETMNSILNGLNGLNISLESSIAVGREFQSVSDLWKTLYDGLESLSDEAPIDEQPTLSQSKTK
What is the function of this protein?
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore.  The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B.  Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
What are the official names of this protein?
DASH complex subunit DAD1, DUO1 and DAM1-interacting protein 1, Outer kinetochore protein DAD1.
What is the protein family that this protein belongs to?
Belongs to the DASH complex DAD1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Protein: RAL2_SCHPO
Sequence: MSEVKRNISLRNSTNIFTSTFSLSSNNVPKPLIGESVIKYGDEAFVYGGRDALNAQLVNDMYVVDLNTCSWKQVEYQGNQKPIPRYFHSGDLWNNKLIFFGGMGFNDDTKCLYVLNDIDIYDIETKQWSHIPGMITENQTNDDAKEVNGSDVDEKSKHLYPSARYGHLHCVLDHYLIIFCGQDLSNSYIEEINIFDLDSGKWVFKSLFNHHCGIYRSNCVVINKDSEFLQMCRPINTTQDSNEHSIGSLFFYLNYNFVNVKRQVIYLELFELDTAESEKKSAALAKDNNQSFRFLELDVTEKFLSSAMPPGLRFPAVNILGDNLILSGIYLTSSRQAFVLWVYSLDKELWLQLDMLGVLNHGSWFKCLVLDCTNRFVVFGNKTRKLTQDYNLRQSNYDHIVFIELEGYGVYRKPQMGRVTERSEQLGKLLLNGISDMEILTIERMHIPCLSRMLYKRWPAFQKIMDRAVEKNQEAFQAEVSQLGPQLTDLPFSSIHSTGSRALYMPYSFETCSAFLHYIYCGTLNGSYCTAKNLCNLLILCKGFEGLETFFAYIVHLLHGVLNRNNVKLIYETAALTGAKGLQLRALRRIARIEQGGTAISPTSPLPNLDD
What is the function of this protein?
Essential for mating and for recognition of the mating pheromone, and for the determination of cell shape.  Implicated in activation of the ras1 protein.
What are the official names of this protein?
Protein ral2.
Protein: NU6C_BUXMI
Sequence: MDLPGPIHDFLLVFLGSGIILGGLGVVLLTNPIFSAFSLGLVLFCISLFHIPSNSHFVAAAQLLIYVGAINVLIIFAVMFTNGSEYYNDFHVWTVGDGVTSLVCTSIFVSLITTILDTSWYGIIWTTRSNQIIEQDLISNGQQIGIHLSTDFFLPFELVSIILLVALIGAIAMARQ
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL2_ECO5E
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: UBID_SALTI
Sequence: MDAMKYHDLRDFLTLLEQQGELKRITLPVDPHLEITEIADRTLRAGGPALLFENPKGYAMPVLCNLFGTPKRVAMGMGQDDVSALREVGKLLAFLKEPEPPKGFRDLFDKLPQFKQVLNMPTKRLRGAPCQQKIASGDDVDLTRLPVMTCWPDDAAPLITWGLTVTRGPHKERQNLGIYRQQLIGKNKLIMRWLSHRGGALDFQEWLAARPGERFPVSVALGADPATILGAVTPVPDTLSEYAFAGLLRGTKTEVVKCLSNDLEVPASAEIILEGYIEPGEMAPEGPYGDHTGYYNEVDNFPVFTVTHITQREDAIYHSTYTGRPPDEPAVLGVALNEVFVPILQKQFPEIVDFYLPPEGCSYRLAVVTMKKQYAGHAKRVMMGVWSFLRQFMYTKFVIVCDDDVNARDWNDVIWAITTRMDPARDTVLVENTPIDYLDFASPVSGLGSKMGLDATNKWPGETQREWGRPIVKDPEVTARIDAIWDELAIFK
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PROF1_HEVBR
Sequence: MSWQTYVDERLMCEIEGNHLTAAAIIGQDGSVWAQSSNFPQFKSEEITAIMSDFDEPGTLAPTGLHLGGTKYMVIQGEAGAVIRGKKGPGGVTVRKTNQALIIGIYDEPMTPGQCNMIVERLGDYLLEQGM
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin-1, Pollen allergen Hev b 8.0101.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: DHMA_PSYCK
Sequence: MKILRTPDSRFANLPDYNFDPHYLMVDDSEDSELRVHYLDEGPRDADPVLLLHGEPSWCYLYRKMIPILTAAGHRVIAPDLPGFGRSDKPASRTDYTYQRHVNWMQSVLDQLDLNNITLFCQDWGGLIGLRLVAENPDRFARVAAGNTMLPTGDHDLGEGFRKWQQFSQEIPQFHVGGTIKSGTVTKLSQAVIDAYNAPFPDESYKEGARQFPLLVPSTPDDPASENNRAAWIELSKWTKPFITLFSDSDPVTAGGDRIMQKIIPGTKGQAHTTIANGGHFLQEDQGEKVAKLLVQFIHDNPR
What is the function of this protein?
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
What are the official names of this protein?
Haloalkane dehalogenase.
What is the protein family that this protein belongs to?
Belongs to the haloalkane dehalogenase family. Type 1 subfamily.
Protein: MURB_STAAC
Sequence: MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVALDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSIIQKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGEHPKES
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPP_LEGPC
Sequence: MSKFLQQKPIILASSSTIRHKLMKSLGLDFLVLPSNCNEEEIKTRHKSDELVELGITLAKIKALDVSQHYPEHYIIAADQLCVAGKRVFNKPLNHQTAVSHLRELSGKQHQQIACLCIVKESKILWQYHETATLTLHHLSEKTIEAYLQAEKPYQSCGAYQYEGLGKWLFKEVQGSEDTILGLPLMPLVNALVNLKVVGI
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STHA_ECO8A
Sequence: MPHSYDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYQNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNARFVDEHTLALDCPDGSVETLTAEKFVIACGSRPYHPTDVDFTHPRIYDSDSILSMHHEPRHVLIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALQNIGLETDSRGQLKVNSMYQTAQPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_STRP2
Sequence: MKTKIIVIVGPTAVGKTALAIEVAKRFNGEVVSGDSQQVYRGLDIGTAKASPEEQAAVPHHLIDVREITESYSAFDFVSEAKMTIEDIHSRGKLAIIAGGTGLYIQSLLEGYHLGGETPHEEILAYRASLEPYSDEELAHLVEQAGLEIPQFNRRRAMRALEIAHFGQDLENQEILYEPLIICLDDERSQLYERINHRVDLMFEAGLLDEAKWLFDHSPNVQAAKGIGYKELFPYFRGEQTFEEARESLKQATRRFAKRQLTWFRNRMQVTFYQIGESGVQDRILSQIEEFLDD
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RS20_YERPS
Sequence: MANIKSAKKRAVQSEKRRKHNASRRSMVRTFIKKVYAAIAAGDKDAAQKAFNEMQPIVDRQSCKGLIHKNKAARHKSNLVAQINAMQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: PABP_CRYNJ
Sequence: MSAETATSPAPAAETPVAPAPATQTTPAEGAPTPAAAAPGGNTVSASLYVGELDPSVTEAMLFEIFNMIGPVASIRVCRDAVTRRSLGYAYVNYLNAADGERALEHLNYSLIKGQSCRIMWSQRDPALRKTGQGNIFIKNLDQSIDNKALHDTFAAFGDILSCKVGTDENGKSRGFAFVHYSTGEAADAAIKAVNGMLLNDKKVYVGHHVGKKERLSKVEELRAQFTNVYIKNVDLEVTDAEFEDLVKPFGPTISVALSRDEKGVSKGFGFVNYENHESARKAVDELNEKEVNGKKLYAGRAQTKSEREAELKKSHEEKRLENEAKSAGVNLYVKNLDDEWDDDRLRAEFEAFGTITSSKVMRDDSGVSRGFGFVCYSSPDEATKAVSEMNGKMIGTKPLYVALAQRKDVRRQALESQIAQRAQQRMQYGAGFPGMQGYMGQPMYGYPPMPGYGQPMPGMPPVRGPMMGYPGAPQNMMQSRPRFNPNGQPLPGGVPAYGMPPQVPYPGAPGYPVRPGGARIPAAPNANGPRNGGPSPVGAPQGLPAGSIPRGGQMPARPHEQAAPAPQAGRLDAQSLARAAPAEQKQMLGEALYPLIHETQPELAGKITGMLLEMDNAELLHLVESQPALQEKVDEALRVLAEWGKDEKPAADEGAEEPKKEEEETKEEEKKE
What is the function of this protein?
Binds the poly(A) tail of mRNA.  Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation.  In the nucleus, involved in both mRNA cleavage and polyadenylation.  Is also required for efficient mRNA export to the cytoplasm.  Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation.  In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).
What are the official names of this protein?
Polyadenylate-binding protein, cytoplasmic and nuclear, PABP, Poly(A)-binding protein, Polyadenylate tail-binding protein.
What is the protein family that this protein belongs to?
Belongs to the polyadenylate-binding protein type-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MLTF_ECOL6
Sequence: MKKLKINYLFIGILALLLAVALWPSIPWFGKADNRIAAIQARGELRVSTIHTPLTYNEINGKPFGLDYELAKQFADYLGVKLKVTVRQNISQLFDDLDNGNADLLAAGLVYNSERVKNYQPGPTYYSVSQQLVYKVGQYRPRTLGNLTAEQLTVAPGHVVVNDLQTLKDTKFPELSWKVDDKKGSVELMEDVIEGKLDYTIADSVAISLFQRVHPELAVALDITDEQPVTWFSPLDGDNTLSAALLDFFNEMNEDGTLARIEEKYLGHGDDFDYVDTRTFLRAVDAVLPQLKPLFEKYAEEIDWRLLAAIAYQESHWDAQATSPTGVRGMMMLTKNTAQSLGITDRTDAEQSISGGVRYLQDMMSKVPESVPENERIWFALAAYNMGYAHMLDARALTTKTKGNPDSWADVKQRLPLLSQKPYYSKLTYGYARGHEAYAYVENIRKYQISLVGYLQEKEKQATEAAMQLAQDYPAVSPTELGKEKFPFLSFLSQSSSNYLTHSPSLLFSRKGSEEKQN
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: RRAA_COLP3
Sequence: MQYNTSELCDFYADLIDVVDPIFCNYGGRSSFAGKVVTLKCFEHLGLINELVATYGTGKVLVIDGGGSTRRALIDLGIAQCAANNGWEGIVCYGSVRDVDALDGVDIGIQALGAIPVGASEQNIGETDMAINFAGVTLLPDDYIYADNTGIILSPEALEIASSMA
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYSM_BOVIN
Sequence: MAASIVRRLGPLVAGRGLRLRGGCVCNQSFKRSFATERQDRNLLYEHAREGYSALPLLDMESLCAYPEDAARALDLRKGELRSKDLPGIISTWQELRQLREQIRSLEEEKEAVTEAVRALVVNQDNSQVQQDPQYQSLRARGREIRKQLTLLYPKEAQLEEQFYLRALRLPNQTHPDVPVGDESQARVLHVVGDKPAFSFQPRGHLEIAEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNFTLNKLIHRGFTPMTVPDLLRGVVFEGCGMTPNAKPSQIYNIDPSRFEDLNLAGTAEVGLAGYFMDHSVAFRDLPIRMVCSSTCYRAETDTGKEPWGLYRVHHFTKVEMFGVTGPGLEQSSELLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVTSASNCTDFQSRRLHIMFQTEAGELQFAHTVNATGCAVPRLLIALLESYQQKDGSVLVPPALQPYLGTDRITTPTHVPLQYIGPNQPQKPRLPGQPASS
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, mitochondrial, SerRSmt, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RPOA_STAEQ
Sequence: MIEIEKPRIETIEVSEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKKLALKIYSEEDKTLEIDVKDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKVRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVSLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: QUEA_GEOSW
Sequence: MKIDLFDFDLPEELIAQTPLPNRDASRLMVLDKKTGEIRHETFRNILSYLHEGDCLVLNDTRVMPARLYGEKENTGANIEVLLLKQLEGDRWETLVKPAKRVKVGTEITFGDGRLKATCVDTLEHGGRILEFSYQGIFYEVLEQLGEMPLPPYIKEKLDDPERYQTVYAREVGSAAAPTAGLHFTEQLLDDIRAKGVHIAFITLHVGLGTFRPVSVENIEEHDMHAEFYQMTEETARLLNEVRQQGGRIIAVGTTSTRTLETIASKHNGAFVAESGWTDIFIYPGYEFKAIDGLVTNFHLPKSTLIMLVSALAGRENILRAYNAAVKERYRFFSFGDAMLII
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUPG_ECOLI
Sequence: MNLKLQLKILSFLQFCLWGSWLTTLGSYMFVTLKFDGASIGAVYSSLGIAAVFMPALLGIVADKWLSAKWVYAICHTIGAITLFMAAQVTTPEAMFLVILINSFAYMPTLGLINTISYYRLQNAGMDIVTDFPPIRIWGTIGFIMAMWVVSLSGFELSHMQLYIGAALSAILVLFTLTLPHIPVAKQQANQSWTTLLGLDAFALFKNKRMAIFFIFSMLLGAELQITNMFGNTFLHSFDKDPMFASSFIVQHASIIMSISQISETLFILTIPFFLSRYGIKNVMMISIVAWILRFALFAYGDPTPFGTVLLVLSMIVYGCAFDFFNISGSVFVEKEVSPAIRASAQGMFLMMTNGFGCILGGIVSGKVVEMYTQNGITDWQTVWLIFAGYSVVLAFAFMAMFKYKHVRVPTGTQTVSH
What is the function of this protein?
Broad-specificity transporter of purine and pyrimidine nucleosides (PubMed:374403, PubMed:15678184, PubMed:3311747, PubMed:11466294, PubMed:15513740).  Can transport adenosine, uridine, thymidine, cytidine, deoxycytidine, guanosine and inosine (PubMed:374403, PubMed:15678184, PubMed:3311747, PubMed:11466294, PubMed:15513740).  Can also transport xanthosine, but with a very low affinity (PubMed:11466294).  Transport is driven by a proton motive force (PubMed:374403, PubMed:15513740).
What are the official names of this protein?
Nucleoside permease NupG, Nucleoside-transport system protein NupG.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COAX_MESM1
Sequence: MNLYLDIGNTNLKFGYEIENQFHFYTLPTLENYTCDMLSKNLESFIKKQKFNYLIVSSVVPSLNLVIKDFASIHLKSKVMFIDKIKKEILNLNGREHSSIGSDIIANALYVSSRYEDAIVISLGTATVIFHVVSKRLEGAIIAPGVKNSYLSLIQSAKKLSEVILKLPRKNLGGNTQEAISLGILKGNFHLINGFINELDPKGKSKILITGGNYGMLKDVLKDYEYVDNMVILGLKDYYEIFK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
Protein: Y1868_HELMI
Sequence: MNDGGKRFYLVDGDILPEAILKTALVNEMLAKGEVTKVSEAVEKVGLSRSAYYKYKDGVLPFREPGRSNIVSVSLLLEHHPGILSRVLNTVAAMEGNILTINQSVPEKGLAPVAFVLDRSRMSVDLPRLLAELRQLTGVRSAQLVGSEEE
What are the official names of this protein?
UPF0735 ACT domain-containing protein Helmi_18680.
What is the protein family that this protein belongs to?
Belongs to the UPF0735 family.
Protein: RLMN_PROM5
Sequence: MKNLLGCSVKDLENVALNYGQAAFRGRQIYSWLYNYKNRSKSIDEINVLPLNFRNQLKKEGFIFGELILKEKYLANDGTLKLLLNTRDNESVECVGIPTEKRLTACLSSQVGCPMDCKFCATGKEGLKRSLKASEILDQILFIENEMNQKVTNIVFMGMGEPLLNIDELLFSIRSINEDFDVSQRRITVSTVAIPNMIRKLSEMSFQVLGKCQFTLAISLHASNQKTRETIIPSAKNYHIKYIIDDCREFVKKTGRRVSFEYLMLHGVNDKLEHADELSNLIKGFQCHVNLIQYNQIEEVEFKQTPSKNAQLFQNRLSNNGINVSLRKSRGSDRNAACGQLRQNAKIK
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1135_BACMK
Sequence: MKLGIVIFPSKMIQDKANGLRKRYDPHYALVPPHITLKTPFETQDEQLESIVNELHTIANKTNPFTLHVGKVGSFAPVNNVLYFKVEKTPELTFLNEEMHNGFFTQEREYSFVPHLTIGQDLSDAEHADVLGRLRMKDFYYEQPIDRFHLLYQLENGTWTVHETFHLGKENN
What are the official names of this protein?
Putative phosphoesterase BcerKBAB4_1135.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. YjcG family.
Protein: SYI_STACT
Sequence: MNYKDTLLMPKTDFPMRGGLPKKEPEIQKQWDEQDLYHKILEKNKGHESYILHDGPPYANGNLHMGHALNKILKDFIVRYKSMQGYYSPYVPGWDTHGLPIEQALTKKGVKRKEMPISEFRKLCEEFALEQIDIQKKDFKRLGVNGDFNDPYITLKPEYEAAQIRLFGEMADRGLIYKGKKPVYWSPSSESSLAEAEIEYHDKRSPSIYVAFDVKDGKGVVDEDAKFIIWTTTPWTLPSNVAITVHPDLKYGQYNVNGEKYVVGQDLVEEVAEELGWDKEDIQLEKEFTGKELEYVETQHPFIDRVSLVINGLHVTTDAGTGAVHTAPGHGEDDYIVGQKYNLPVISPLNDKGVFTEEGGQFEGMFYDKANKAVTDLLKENGSLLKLKFITHSYPHDWRTKKPVIFRATPQWFASISKVRQDILDAIEDTNFKVDWGKTRIYNMIRDRGEWVISRQRVWGVPLPVFYTENGDIIMDKEVIYHVANLFEKYGSNVWFDRDAKDLLPEGFTHPGSPNGEFTKEEDIMDVWFDSGSSHRGVLETRPELSFPADLYLEGSDQYRGWFNSSITTAVATRGQSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQIVKQKGADIARLWVSSVDYLSDVRISDEILKQTADVYRKIRNTLRFMLGNVNDFNPETDAVPESDLLEVDRYLLNRLREFTESIINHYDNFDYLNIYQEVQNFINVELSNFYLDYGKDILYIEKQDSHKRRSMQTVLYQILVDMTKLLAPILAHTSEEVWSYIPHVKEESVHLADMPEVVKPDEELLEKWNTFMKLRDDVNRALEEARNNKVIGKSLEAKVIIGSNESFDAADFLKDFENLHQLFIVSQVEVEEKVEDGNEYYYGDIKVVHADGEKCERCWNYSTELGSVNGLDHLCPRCQGVVADL
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_YERE8
Sequence: MTILNHTLGFPRVGLKRELKKAQESYWAGNSTQEELLNVGRELRARHWQQQQQAGVDLVPVGDFAWYDHVLTTSLLLGNVPERHQNADGSIDLDTLFRIGRGRAPTGTPAAAAEMTKWFNTNYHYMVPEFQQGQQFKLGWTQLLDEVDEALALGHKIKPVLLGPVTYLWLGKVKGEQFDRLSLLKDILPVYQQVLGELAKRGIEWVQIDEPALVLELPPEWLDAYQPAYQALQGQVKLLLTTYFDSIGHNLDTIRALPVQGLHVDVVAGQDDIAKLNAKLPQEWLLSLGVINGRNVWRADLSHWFERLQPLVNSRPLWLGSSCSLLHSPIDLSEETRLDAEVKSWFAFALQKCAELALLTQALNAPSEAKLAELAAYSAPIRARRASSRVHNPQVEQRLAAITAQDIERQQPYEARAAAQRKRFNLPAWPTTTIGSFPQTTEIRGLRLDFKQGRLDGKNYRTGISEHIKQAIAEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVIIGDISRPEAITVEWAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVSRETIAKQIALALRDEVEDLEKAGIGIIQIDEPALREGLPLRRADWQAYLQWAVDAFKLNAAVAQNDTQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEDFAYPNEIGPGVYDIHSPNVPSVEWIEALLRKAAQRIPAERLWVNPDCGLKTRGWPETRQALANMVLAAQRLREEQV
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.