PharMolix/UniProtQA huggingface dataset:
Protein: RNF12_HUMAN
Sequence: MENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGESTEEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLASGNRESVV
What is the function of this protein?
E3 ubiquitin-protein ligase.  Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex.  Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM.  Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1.  By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
What are the official names of this protein?
E3 ubiquitin-protein ligase RLIM, LIM domain-interacting RING finger protein, RING finger LIM domain-binding protein, R-LIM, RING finger protein 12, RING-type E3 ubiquitin transferase RLIM, Renal carcinoma antigen NY-REN-43.
What is the protein family that this protein belongs to?
Belongs to the RNF12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EGR1_DANRE
Sequence: MAAAKTEMLLPALQISDPLSFPHSPTDNYPKLEEMIMLNSAGTPFLNATAPEGAVFGSGEPGEQFDHLAGDTLSEISMEKPLSDQTYSTQRLPPISYTGRFTLEPATNCSNSLWAEPLFSLVSGLVGINPPPASIPSSTSQATHPSSSSTSSIPSSSSSSTSSASLSCSVHQSEPNPIYSAAPTYSSASPDIFPESGPNFSTTVGTSLQYSSSTYPSAKTCNPSFSVPMIPDYLFTQQQSEISLVPPDQKPIQTQAGQQPALTPLHTIKAFATQTGSQDLKSVYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVETCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACEICGRKFARSDERKRHTKIHMRQKDKKAEKGATAAVQSSVSNISISASSPVSSYPSPITSYPSPVSSFPSPVNSCYSSPVHTSYPSPSIATTYPSATSTFQTQVATSFPTSVASNIYSSPVTTPLPDMQSALSPRTADIC
What is the function of this protein?
Transcriptional regulator (PubMed:7945937).  Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity).  Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity).  Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia.  Plays a role in the regulation of cell survival, proliferation and cell death.  Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity).  Plays a role in regulating the expression of circadian clock genes (By similarity).
What are the official names of this protein?
Early growth response protein 1, EGR-1, Zinc finger protein Krox-24.
What is the protein family that this protein belongs to?
Belongs to the EGR C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ELMD1_MOUSE
Sequence: MKHFLRMLIQVCLYFYCKFLWRCMKFVMRKLTGRCELQRICYGTKPGASRTMKIETSLRDSKSKLLQTSVSVHPDAIEKTIDDIMELKKINPDINPQLGISLQACLLQIVGYRNLIADVEKLRREPYDSDNPQHEEMLLKLWELLKPNTPLESRVSKQWCEIGFQGDDPKTDFRGMGLLGLYNLQYFAERDATVAQQVLSDSVHPKCSKFSKIEWEKKKMDKAIGYSFAIVGINITDLAYNLLVSGALKTHFYNIAPEAPTLSHFQQTFCYLMHEFHKFWIEEDPMDIMEFNRVREKFRKRIIKQLQNPDMALCPHFAASEGLINM
What is the function of this protein?
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.
What are the official names of this protein?
ELMO domain-containing protein 1.
Protein: YHDU_ECO57
Sequence: MIRKYWWLVVFAVFVFLFDTLLMQWIELLATETDKCRNMNSVNPLKLVNCDELNFQDRM
What are the official names of this protein?
Uncharacterized protein YhdU.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CCMA_RICCN
Sequence: MLSLHQLQFKNLFDLNITFLPSSITYIKGANGCGKSSLLRMIAGIMQPSSGHIYYRNCNINNIAKLYCTYIGHNLGLKSEMTVFENLKFWSEIYNSAATVYAAIHYFKLHDLLDKKCYSLSSGMQKIVAIARLIACQSDLWLLDEVETNLSKENRALLNNLIVMKANSGGIVLLSSHLESSIKSAQILRID
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Q0297_YEAST
Sequence: MKMKTNKYMNMVRPAPPRRADPEGVRDPSTMGGGPNPFLRRSPYMYINKKK
What are the official names of this protein?
Putative uncharacterized protein Q0297, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TBX19_HUMAN
Sequence: MAMSELGTRKPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSAHRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQHVTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAYMHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLTSIAVSTWTAVASHPFAGWGGPGAGGHHSPSSLDG
What is the function of this protein?
Transcriptional regulator involved in developmental processes.  Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.
What are the official names of this protein?
T-box transcription factor TBX19, T-box protein 19, T-box factor, pituitary.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDRP_BACAH
Sequence: MDNKIVYVVSDSVGETADLVVRAAMGQFPFAPDIRRVPYVEDTGTLKEVISIAKSNQALICFTLVKPDMRQYLVTEAAKEGVEAYDIIGPLIDQIEEITGQVPRYEPGVVRRLDEEYFKKIEAIEFAVKYDDGRDARGILKADIVLIGISRTSKTPLSQYLAHNKRLKVANVPLVPEVDPPEELYQVAKEKCFGLKITPEKLNHIRKERLKSLGLSDGATYANINRIKEEIDHFENVVSKINCQVIDVSNKAIEETANIIVNAVQNQKMF
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: NRAM_I77AG
Sequence: MNPNQKIICISATGMTLSVVSLLIGIANLGLNIGLHYKVGDTPDANTPNVNETNSTTTIINNNTQNNFTNITNIIVSKNEERTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRMFALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNVRVECIGWSSTSCHDGISRMSICMSGPNNNASAVVWYGGRPVTEIPSWAGNILRTQESECVCHRGICPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSCYGAVGMIKCICRDNWKGANRPVITIDSEMMTHTSKYLCSKVLTDTSRPNDPTNGDCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVPNAETDTRSEPTSHQVIINNQNWSGYSGAFIDYWANKECFNPCFYVELIRGRPKESSVLWTSNSIVALCGSRERLGSWSWHDGAEIIYFK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: PADI6_MOUSE
Sequence: MSFQNSLSLSLVNPTHALCMVGMEITLDISKCAPDKCKSFTIRGSPRILIHISSSVIAGKEDTVVWRSMNHPTVALVRMVAPSPTVDEDKVLVSYFCPDQEVPTATAVLFLTGIEISLEADIYRDGQLDMPSDKQAKKKWMWGMNGWGAILLVNCSPNAVGQPDEQSFQEGPREIQNLSQMNVTVEGPTSILQNYQLILHTSEEEAKKTRVYWSQRGSSAYELVVGPNKPVYLLPTFENRRKEAFYVEATEFPSPSFSGLISLSLSLVEKAHDECIPEIPLYKDTVMFRVAPYIFMPSTQMPLEVYLCRELQLQGFVDSVTKLSEKSKVQVVKVYEDPNRQSKWLQDEMAFCYTQAPHKTVSLILDTPRVSKLEDFPMKYTLTPGSGYLIRQTEDHRVASLDSIGNLMVSPPVKAQGKDYPLGRVLIGGSFYPSSEGRDMNKGLREFVYAQQVQAPVELFSDWLMTGHMDQFMCFVPTNDKNNDQKDFRLLLASPSACFELFEQKQKEGYGNVTLFEDIGAEQLLSNGRESKTISQILADKSFREQNTYVEKCISLNRTLLKTELGLEDKDIILIPQLFCLEQLTNVPSNQQSTKLFARPYFPDMLQIIVLGKNLGIPKPFGPKINGTCCLEEKVCGLLEPLGLKCTFIDDFDCYLANIGDVCASAIINRVPFAFKWWKMTP
What is the function of this protein?
Catalyzes the deimination of arginine residues of proteins (By similarity).  In oocytes, is released during cortical reaction and plays a role in preimplantation cleavage and early embryonic development (PubMed:16137333).  May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:17587491).
What are the official names of this protein?
Protein-arginine deiminase type-6, Arginine deiminase-like protein, Egg and embryo abundant PAD, ePAD, P75, Peptidylarginine deiminase VI, Protein-arginine deiminase type VI.
What is the protein family that this protein belongs to?
Belongs to the protein arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Note=Predominantly cytoplasmic (oocyte cytoplasmic sheets), also nuclear. Released extracellularly during the cortical reaction, and remains associated with the blastomeres surfaces as a peripheral membrane protein until the blastocyst stage of development (PubMed:16137333).
Protein: MSHB2_SACEN
Sequence: MLVHAHPDDESTGTGATMARYANEGATVSLVTCTSGELGEVVADDLAHLRGNPDALGEHRRGEIAEALRELGDIRHHWLGGPGRFRDSGMAGEDTNDAAECFAKADRDDVTRAMVEILRAERPHVVVTYDDTGGYGHPDHIAANHALMYALGPAADPAYLPELGEPWDVPKVYWMTLPRSFVKDVQAAGIEGFEPFTVPDEDITAVLDGRDHHAKKLAALRTYRSQVSLDDGDFFATLVQDPRFAIEHYVLVRGERGPGSGPHNWENDLFAGLD
What is the function of this protein?
Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
What are the official names of this protein?
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase 2, GlcNAc-Ins deacetylase 2, N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase 2.
What is the protein family that this protein belongs to?
Belongs to the MshB deacetylase family.
Protein: EIF3C_RAT
Sequence: MSRFFTTGSDSESESSLSGEELVTKPVSGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYVRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITNYKQNPEQSADEDAEKNEEDSEGSSDEDEDDDGVSGTAFLKKKPDSSGESRKFHKKMEDDDEDSEDSEDEEWDTSSTSSDSDSEEEEGKQTVLASKFLKKAPTTEEDKKAAEKKREDKAKKKHDRKSKRMDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQVRGKKGTDRATQIELLQLLVQIASENNLGVGVIVKIKFNIIASLYDYNPNLATYMKPEMWQMCLDCINELMDTLVAHSNIFVGENILEESENLHNFDQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEICQIYLRRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.  The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).  The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.  The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 subunit 8, eIF3 p110.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALFC2_PEA
Sequence: GSYADELVKTAKTIASPGRGILAMDESNATCGKRLDSIGLENTEANRQAWRTLLVTVPTLGEYISGAILFEETLYQSTVDGRKIVDVLVEQNIIPGIKVDKGLVPLAGSNNESWCQGLDGLASRSAAYYQQGARFAKWRTVVSIPNGPSALAVKEAAWGLARYAAISQDNGLVPIVEPEILLDGEHGIDRTFEVAQKVWAEVFYYLAENNVQFEGILLKPSMVTPGAESKDKASPTKVAEYTLNLLHRRIPPAVPGIMFLSGGQSEVEATLNLNAMNKSPNPWHVSFSYARALQNTALKTWGGLPENVKAAQEALLFRAKSNSLAQLGKYIGDGESEEAKKDCCQGYSY
What are the official names of this protein?
Fructose-bisphosphate aldolase 2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RSMC_SHEFN
Sequence: MLTNPSQALIRNSKYFQQHSVLVLNYEADTFAHQCLEFADNVTALALDYNHHLTLSSCANEKLQSYFGHQLPESLADTKFDSVIIYFPKAKPLMGYLLQLAAQHLNVDGQLIIVGENKGGIKSIAKLTPDYYSQPIKQDNARHCLVYVSYLIQAAPTLSIRDWVSQYSLETPQGTLQICNAVGVFSEKRLDQGTDLLLSHLPDNLRGRVLDFGCGAGVITAALLKANPELTIECIDINAMALLSCELTLAANSMQAKVYPSDGFNQITGKFDGIISNPPFHDGLTSTTDIATQFVQQSAIRLTSNGIWQIVANRHLPYSETIATHFGKVNVVAENNKYKLYLHQR
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y00A_BPT4
Sequence: MKSYKVNLELFDKAVHREYRIIQRFFDMGEAEEFKTRFKDIRDKIQSDTATKDELLEVAEVIKRNMN
What are the official names of this protein?
Uncharacterized 8.1 kDa protein in rIIA-Gp60 intergenic region.
Protein: RL16_FERNB
Sequence: MLMPKRVKYRKQHRGRTKGDAKGGALVMFGEYGLKALEPAWITAQQIEACRLAITRTLKKEGKLWIKIFPDKSYTKHPPETKLGKGKGNVEGWVAVVKPGKVMFEIGGVEEELAIKALEYAATKLPIKTKIVTRHHIGGEAV
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: APC3_SCHPO
Sequence: MTDRLKCLIWYCIDNQNYDNSIFYSERLHAIEDSNESLYLLAYSHFLNLDYNIVYDLLDRVISHVPCTYLFARTSLILGRYKQGISAVEACRSNWRSIQPNINDSISSRGHPDASCMLDVLGTMYKKAGFLKKATDCFVEAVSINPYNFSAFQNLTAIGVPLDANNVFVIPPYLTAMKGFEKSQTNATASVPEPSFLKKSKESSSSSNKFSVSESIANSYSNSSISAFTKWFDRVDASELPGSEKERHQSLKLQSQSQTSKNLLAFNDAQKADSNNRDTSLKSHFVEPRTQALRPGARLTYKLREARSSKRGESTPQSFREEDNNLMELLKLFGKGVYLLAQYKLREALNCFQSLPIEQQNTPFVLAKLGITYFELVDYEKSEEVFQKLRDLSPSRVKDMEVFSTALWHLQKSVPLSYLAHETLETNPYSPESWCILANCFSLQREHSQALKCINRAIQLDPTFEYAYTLQGHEHSANEEYEKSKTSFRKAIRVNVRHYNAWYGLGMVYLKTGRNDQADFHFQRAAEINPNNSVLITCIGMIYERCKDYKKALDFYDRACKLDEKSSLARFKKAKVLILLHDHDKALVELEQLKAIAPDEANVHFLLGKIFKQMRKKNLALKHFTIAWNLDGKATHIIKESIENLDIPEENLLTETGEIYRNLET
What is the function of this protein?
Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.  Interacts with spindle apparatus, chromosomes, or nuclear envelope, and interconnect nuclear and cytoskeletal functions in mitosis, so the elongation of the spindle in anaphase is blocked.
What are the official names of this protein?
Anaphase-promoting complex subunit 3, 20S cyclosome/APC complex protein apc3, Nuclear alteration protein 2, Nuclear scaffold-like protein p76.
What is the protein family that this protein belongs to?
Belongs to the APC3/CDC27 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRD_NEIMA
Sequence: MYPLARRILFALDAEKAHHFTLDALYTVYKLGLIPVTDNRTKPVKLMGMDLPNPVGLAAGLDKNGEYIDALGALGFGFIEIGTVTPKPQPGNPQPRLFRVPEHQGIINRMGFNNHGIDTMIRNIEKSKFSGVLGINIGKNAVTPIENAADDYLICLEKAYAHASYITVNISSPNTKNLRALQGGDELSALLEALKNKQAQLASVYGKYVPLAVKIAPDLDEAQIEDIAHVVKSVEMDGIIATNTTIDKSSLGSHPLAGEQGGLSGLPVHEKSNRVLKLLADHIDGKLPIIGVGGIMEGGDAADKIRLGATAVQVYSGLIYKGPALVKECLKALAR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL17_CELJU
Sequence: MRHRLSGRQLGRNSSHRKAMFRNMSASLVEHELIKTTLPKAKELRRVIEPLITLAKVDSVANRRLANARLQSKSAVGKLFSELGKRYATRPGGYVRILKCGFRAGDKAPMAYVELVDRPARAVETAVEVDAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: MURD_CERS1
Sequence: MIPVRGLEGRKVAVLGLGRSGLATARALEAGGAEPLLWDDSPEARAKAEGQGFTVTDLTRERAFEGVALLVTSPGIPHLYPAPNPVIARAMAAGVPVDNDIGLFFRSFATRDWDAFDQMPRVVCVTGSNGKSTTTALIHHILSEAGRPTQMAGNIGRGVLDLDPARDGEVVVLELSSYQTDLARALTPDVAVFTNLSPDHLDRHGGMGGYFAAKRRLFAEGGPDRAVIGVDEPEGLYLAGQLSVAPEDDRVIRISAGQKLERFGWSVFARKGFLAEWRKGRQMASIDLRAMPGLPGAHNHQNACAAYAACRTLGLAPRQIEAALASFAGLPHRSQTVGEKGGVRFVNDSKATNVDSAAKALQAFPKIRWIAGGLGKDGGIAALQPHLGSVVKAYLIGHSARDFALQIGATDHEICETMERAVARAAEEAQPGEVVLLAPAAASFDQYPNFEKRGEDFMEKVKALL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_ANAMM
Sequence: MMIIGIDPGLEFTGWGVVSSTNSQSVCLLDSGVISTRGISRESEKLYKIYVSLLSVLSLYKIDEASIEKVFINSNPRSSMSLCYARAASTISVMSRGIDIYEYSSTAIKKCITGNGMAPKEQVSFMVRSSLGIKQDVEINNHSSDAIAAALCHVYNTRNRNFALK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: ICR3_ARATH
Sequence: MQTQKARNGSPDVPKKVSPRAARPLKIAALEPESSSSPISATNRTPKDKSPNVLNRRSPRSPVSEKKRPSRITELELLVSQLQEELKKAKDQISVSETSKKQAEQEAEESRKQLQEVSSKLEESQNQFVETSALEEETDKTGSLVFQSVSQECDWEFSATAGERAGLAAVAHEIRQLKLQIEMVASSEAGHVKQAELYNSEVQLLRGNLMDTLFHVENFRNQLKDCEISEAETEALATETLRQLENAKKAVEELKSDGTKAVESYKKMAVELEQSKSRMVWLEALVNKLQNNPADLENHEILLKDYESLRRGESNEMDEEVSSLRCEVERLRAALEASDKKDQEGNVEASSRLRIQAELQSELKIAKSEIDELKARLMDKETELQFISEERDNFSMKLMKNQKEIDVEAELKKLREAIENLKADLMDKETELQIVSDENETLKSDIHKSETDVQDAFLKLGIAMEEADKSSKKAVRVTEQLEATQASNSEMETELRKLKVQSNQWRKAAEAATAMLSAGNNGKFAENYNQTNSPYSEDIDDELTKKKNGNVLKKIGVLWKKPQK
What is the function of this protein?
Acts as a scaffold, mediating interaction of ROPs with different proteins.
What are the official names of this protein?
Interactor of constitutive active ROPs 3, ROP-interactive partner 5.
What is the protein family that this protein belongs to?
Belongs to the ICR family.
Protein: SODC1_DICDI
Sequence: MSKTAVCVIKGEKVNGVVKFTQENKDSPVTVNYDITGLEKGEHGFHVHAFGDTTNGCVSAGPHFNPFGKNHGAPSDEDRHVGDLGNIVADGESNTKGTISDKIISLFGEHTIVGRTMVVHADQDDLGKGGKPDSLTTGAAGARLGCGVIGVSQ
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn] 1.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
Protein: GLSA_SALAR
Sequence: MARAMDNAILETILQRVRPLIGQGKVADYIPALASVEGSKLGIAICTVDGQHYQAGDAHERFSIQSISKVLSLVVAMRHYPEEEIWQRVGKDPSGSPFNSLVQLEMEQGIPRNPFINAGALVVCDMLQGRLSAPRQRMLEVVRALCGVSDITYDATVARSEFEHSARNAAIAWLMKSFGNFHHDVPTVLQNYFHYCALKMSCMELARTFVFLANQGEAFHLDEPVVTPMQARQINALMATNGMYQNAGEFAWRVGLPAKSGVGGGIVAIVPHEMAIAVWSPELDPAGNSLAGIAALEQLTQTLGRSVY
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: GPR42_HUMAN
Sequence: MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLRCRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFWKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLVAATLLNFLVCFGPYNVSHVVGYICGESPVWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAEN
What is the function of this protein?
Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.
What are the official names of this protein?
G-protein coupled receptor 42.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.