PharMolix/UniProtQA huggingface dataset:
Protein: ATG15_CANGA
Sequence: MLGRQVTMLLKVIVAVAVLFVWHRSRDSSRGDGSNGDGLSDSSGNGFRLEHIWAYDPEDVVSSCVDVSEEMRVSADEYVSMESGSEFVESWWAKTGARPFSHVFDLRSRSMDIQRLQDRDPVSMEKYIDFSLENPELARTIELEWETAKIQVPDVRNRNTVLALALMSSNAYVRTPYTGDWRNLSSSWGHTGEEKFGWDKDGLRGHIFVNKITKVVVIAIKGTSSQGLFGSGEEDTITNDKINDNLLFSCCCARISYLWTTVCDCYMKSYTCDENCVEAELKRKDRYYAATLKLYKQVTEMYPDSAIWLTGHSLGGALAALLGRTYGVPAVTFEAPGELLPAKRLHLPLPPGLPDYEEAIWHFGHNADPIFMGTCNGASSSCSIGGYAMETACHSGQYCMYDVVNDKGWRVNLLNHRIHRVIDEVILEYGRPAKCQRAPTCIDCYNWKFVNKRRNRREESSSSIASSSQLTSSHSESETLTSTDAPEKTCIGRNWLGICTDYGV
What is the function of this protein?
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies.  Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles.  The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).
What are the official names of this protein?
Putative lipase ATG15, Autophagy-related protein 15.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Protein: F16PA_SHEWM
Sequence: MQTLAQNLTSQGVDASLTQLIHTLANTSKEISHAVRHGALAGVLGATEQENVQGETQKKLDVITNDMLKDALKADNTVRGLASEEEDYIVEVGDKGEYLVCFDPLDGSSNIDINSLVGTIFSVLPAPTGELTESSFLQAGRKQVAAGYVLYGPSTMLALTTGKGVQLFTLNPETNEYLLTTEAMSISKDTGEFAINMSNQRFWEAPMQTYISDLLLGTIGPREKAFNMRWIAAMVGDVHRVLSRGGIFTYPTDNKNPQKPYKLRLMYEANPMSFLVEQAGGIASTGYEAIMDIEPSEIHQRVAVILGSANEVKACLEYHSLDYSEEPAL
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSMD4_MOUSE
Sequence: MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATPGTEDSDDALLKMTINQQEFGRPGLPDLSSMTEEEQIAYAMQMSLQGTEFSQESADMDASSAMDTSDPVKEEDDYDVMQDPEFLQSVLENLPGVDPNNAAIRSVMGALASQATKDGKNDKKEEEKK
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.  PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction.  Displays a preferred selectivity for longer polyubiquitin chains.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 4, 26S proteasome regulatory subunit RPN10, 26S proteasome regulatory subunit S5A, Multiubiquitin chain-binding protein.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S5A family.
Protein: KGUA_LISMO
Sequence: MTERGLLIVLSGPSGVGKGTVREAVFKDPETSFDYSISMTTRLPREGEQDGVDYYFRSREVFEQAIKDGKMLEYAEYVGNYYGTPLEYVEEKLAAGVDIFLEIEVQGAMQVRKAMPEGIFIFLTPPDLSELKNRIIGRGTESMEVVEERMETAKKEIEMMASYDYAVVNDVVANAVQKIKGIVETEHLKTERVIHRYKKMLEGLQ
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18E_THEAC
Sequence: MDVSNKVSRALTQEIETLANISRESGSKLWRDIAERLASRRRGYASVNLSKIDKYAKDGDIIVVPGYVLGVGKISKKVTVGAYKFSKTAMEKLSNSGCAFMNISEIAKDNPKGTNVKIMR
What are the official names of this protein?
50S ribosomal protein L18e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL18 family.
Protein: TRM5_FUSV7
Sequence: MDKNSQLRDMNLFRAPAARAAKTLDRSVFAKTLNAAAASISENRLLSKYRKELEKTQEVLFMERFNPILPDPDPSLASQGRKCIVLSPQIKPASPETWSPTLQEASKLGELKVVPYDLEITYDFWNYFDVVKSILPEELHGEIPSGFNTVGHVAHLNIRDQYLPYKNIIAQVLLDKNPHIKTVINKIDNVGSENEFRTFAYEVLGGPDNMNVEVSEAGCIFRFDYSKVYWNSKLDTEHKRITSFFKPGEVVADVMAGIGPFAVPAGKKGVFVWANDKNPESHRYLEDAIQKNKVWEFVKPFNHDGHDFIRTSADLVLEASKRGDCAVIKPPRPPRKSAAPPPEPVRVPVPPTISHFVMNLPASAIEFLHNYRGLYHGHEDLFEPHTETKLPIVHVHCFSAKMDDDTPLKDICERIHKEIGVMLKPGDAEKEGEVLIYDVRDVAPAKRMFCASFRLPREVAFAARA
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Protein: DDX54_HUMAN
Sequence: MAADKGPAAGPRSRAAMAQWRKKKGLRKRRGAASQARGSDSEDGEFEIQAEDDARARKLGPGRPLPTFPTSECTSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKTHSAQTGARALILSPTRELALQTLKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLVHVAVEMSLKLQSVEYVVFDEADRLFEMGFAEQLQEIIARLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDTKLNEQLKTSFFLVREDTKAAVLLHLLHNVVRPQDQTVVFVATKHHAEYLTELLTTQRVSCAHIYSALDPTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEIPYLLDLHLFLGRSLTLARPLKEPSGVAGVDGMLGRVPQSVVDEEDSGLQSTLEASLELRGLARVADNAQQQYVRSRPAPSPESIKRAKEMDLVGLGLHPLFSSRFEEEELQRLRLVDSIKNYRSRATIFEINASSRDLCSQVMRAKRQKDRKAIARFQQGQQGRQEQQEGPVGPAPSRPALQEKQPEKEEEEEAGESVEDIFSEVVGRKRQRSGPNRGAKRRREEARQRDQEFYIPYRPKDFDSERGLSISGEGGAFEQQAAGAVLDLMGDEAQNLTRGRQQLKWDRKKKRFVGQSGQEDKKKIKTESGRYISSSYKRDLYQKWKQKQKIDDRDSDEEGASDRRGPERRGGKRDRGQGASRPHAPGTPAGRVRPELKTKQQILKQRRRAQKLHFLQRGGLKQLSARNRRRVQELQQGAFGRGARSKKGKMRKRM
What is the function of this protein?
Has RNA-dependent ATPase activity.  Represses the transcriptional activity of nuclear receptors.
What are the official names of this protein?
ATP-dependent RNA helicase DDX54, ATP-dependent RNA helicase DP97, DEAD box RNA helicase 97 kDa, DEAD box protein 54.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: A20_VACCA
Sequence: MTSSADLTNLKELLSLYKSLKFSDSAAIEKYNSLVEWGTSTYWKIGVQKVANVETSISDYYDEVKNKPFNIDPGYYIFLPVYFGSVFIYSKGKNMVELGSGNSFQIPDDMRSACNKVLDSDNGIDFLRFVLLNNRWIMEDAISKYQSPVNIFKLASEYGLNIPKYLEIEIEEDTLFDDELYSIIERSFDDKFPKISISYIKLGELRRQVVDFFKFSFMYIESIKVDRIGDNIFIPSVITKSGKKILVKDVDHLIRSKVREHTFVKVKKKNTFSILYDYDGNGTETRGEVIKRIIDTIGRDYYVNGKYFSKVGSAGLKQLTNKLDINECATVDELVDEINKSGTVKRKIKNQSAFDLSRECLGYPEADFITLVNNMRFKIENCKVVNFNIENTNCLNNPSIETIYGNFNQFVSIFNIVTDVKKRLFE
What is the function of this protein?
Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein D4.  May serve as a bridge which links the DNA polymerase E9 and the uracil DNA glycosylase (By similarity).
What are the official names of this protein?
DNA polymerase processivity factor component A20.
What is the protein family that this protein belongs to?
Belongs to the poxviruses A20 family.
Protein: SPRY7_CHICK
Sequence: MAASVFCCLRWCRDGGAGHIPLKEMPAVQLDTQRMGTDVVIVKNGRRICGTGGCLANAPLHQNKSYFEFKIQSTGIWGIGVATQKANLNQIPLGRDVHSLVMRNDGALYYNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF
What are the official names of this protein?
SPRY domain-containing protein 7, Chronic lymphocytic leukemia deletion region gene 6 protein homolog, CLL deletion region gene 6 protein homolog.
Protein: GREA_BUCCC
Sequence: MFNKIPMTLRGFNKLKSELKKLKYITRPCIVKAIANARQLGDLKENAEYHSAREEQSFCENRICEIENKLLRAQIIDITKIPFKGIVIFGSTVTVLQISTSNIFVYTIVGDDEANYKEFSISIHSPMSRALIGKKKNDIIKVNTPTGYIKYIIKKIEYI
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: FMT_STAA9
Sequence: MTKIIFMGTPDFSTTVLEMLIAEHDVIAVVTQPDRPVGRKRVMTPPPVKKVAMKYDLPVYQPEKLSGSEELEQLLQLDVDLIVTAAFGQLLPESLLALPKLGAINVHASLLPKYRGGAPIHQAIIDGEQETGITIMYMVKKLDAGNIISQQAIKIEENDNVGTMHDKLSVLGADLLKETLPSIIEGTNESVPQDDTQATFASNIRREDERISWNKPGRQVFNQIRGLSPWPVAYTTMDDTNLKIYDAELVETNKINEPGTIIETTKKAIIVATNDNEAVAIKDMQLAGKKRMLAANYLSGAQNTLVGKKLI
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: CMOB_HAES1
Sequence: MFDFRPFYQQIATSTLSAWLETLPLQLKQWEKQTHGDYIKWSKIIDFLPHLTADHIDLKSAVKAETKTPLSSGERQRIIHHLKQLMPWRKGPYHLYGIHIDCEWRSDFKWERVLPHLAPLQNRLVLDVGCGSGYHMWRMVGEGAKMVVGIDPTELFLCQFEAVRKLLNNDRRANLIPLGIEEMQPLAAFDTVFSMGVLYHRKSPLDHLTQLKNQLVKDGELVLETLVVEGDINTTLVPTDRYAKMKNVYFIPSVLALINWLEKCGFHNIRCVDVETTGLEEQRKTDWLENESLIDFLNPQDHSKTIEGYPAPKRAVILANK
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: 3MGH_LACH4
Sequence: MNYSDYFTNRPTDEITRDLVGRPLIYDNGKEKIGGYIVEAEAYMGKNDRTAHSYGGHRSPANEGLYRRGGTIYIYAQRQYFFFDVACQEENEPQGVLIRAIEPIWGIDTMIKNRSGKSGVLLTNGPAKMMQAFGIHDKNWNLHFLSDSPFKIDLEDDHRKPAQEIIADKRVGINQSDPVWANKKLRYYVAGNPYVSDMKKRNYAKNNGWA
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: COX2_CHRBR
Sequence: MAYPFQLGLQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISSMLTTKLTHTSTMDAQEVETVWTILPAIILVLIALPSLRILYMMDETNNPSLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTQELKPGELRLLEVDNRVVLPMEMTIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMAMRPGLYYGQCSEICGSNHSFMPIVLEMVPLSYFETWSALMV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CDN1B_NEOVI
Sequence: MSNVRVSNGSPSLERMDARQAEYPKPSACRNLFGPVNHEELTRDLEKHRRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGTRQAVPLMGSQANSEDTHLVDQKTDTADNQAGLAEQCTGIRKRPATDDSSPQNKRANRTEENVSDGS
What is the function of this protein?
Important regulator of cell cycle progression (PubMed:8288131).  Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (By similarity).  Involved in G1 arrest (PubMed:8288131).  Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes.  Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation.  Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1.
What is the protein family that this protein belongs to?
Belongs to the CDI family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. Mitogen-activated UHMK1 phosphorylation on Ser-10 results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export (By similarity). Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity).
Protein: DRE2_CLAL4
Sequence: MSEILLLLHPTVVTEESLVESAKSGLSGKFPEASLTQHIIDRIANDMVELPSSHFDHIHYVNPNKSHLSIPPSVMAKLFASLKNGGELSGDLPKDQDLDVLMNGFIVKDDGSWSKPAPVSTVLLRKKKPAETAARKMPTFKKPVSSPVTLTDTSANNTDAEDDLSMKRKLDSTKLAYFSDDSSGEEDDLIDENELIADSHKFNVNIVVPKKCELPNGKKRKKACKDCTCGLKELEEQEEQATRNLQDTLLGKMAQSATLEAIKIEERLKKSQVQFSAQDLTEIDFTVEGKTGGCSSCALGDAFRCDGCPYLGLPPFKPGEVVTLDSFGEDI
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein DRE2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: RS6_HAMD5
Sequence: MRHYEIVFMVHPDQSDQVPGMIQRYSTVITQSGGQIHRIEDWGRRQLAYAINKLHKAHYVLLNVEAPQNAINELETNFRFNDAVMRNLIKRMNHAVTEESPIIKMKDERREVVELTTSGSEDNQKDHHKEDLDKKTDEFSEEN
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RPO3_SULAC
Sequence: MPISLIERNGLRLRLVLENYPLEFVNSIRRASILYVPVMAVDEVYFIENNSPLYDEILAHRLALVPFVSDEALEHYRPPEECAECKENCDGCYNRVYLDVEAKDQPLMIYSRDLKSEDQMITPVSGAIPIVLLGSKQKISLEARLRLGYGKEHIKYSPVSVSIVRYYPKVTVLGNCEKAVEVCPEGVFAMENNKLVVKNELSCILCEECLKYCAGSVSIESVENKFILEIESVGSLKPERILIEASKSLLRKLSELKSKLEAGK
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo3, DNA-directed RNA polymerase subunit D.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHMD_SALG2
Sequence: MENIMTLPKIKHVRAWFIGGATAEKGAGGGDYHDQGGNHWIDDHIATPMSKYRDYEQSRQSFGINVLGTLIVEVEAENGQTGFAVSTAGEMGCFIVEKHLNRFIEGKCVSDIKLIHDQMLGATMYYSGSGGLVMNTISCVDLALWDLFGKVVGLPVYKLLGGAVRDEIQFYATGARPDLAKEMGFIGGKMPTHWGPHDGDAGIRKDAAMVADMREKCGPDFWLMLDCWMSQDVNYATKLAHACAPFNLKWIEECLPPQQYEGYRELKRNAPAGMMVTSGEHHGTLQSFRTLAETGIDIMQPDVGWCGGLTTLVEIAALAKSRGQLVVPHGSSVYSHHAVITFTNTPFSEFLMTSPDCSTLRPQFDPILLDEPVPVNGRIHKSVLDKPGFGVELNRDCHLKRPYSH
What is the function of this protein?
Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).
What are the official names of this protein?
L-rhamnonate dehydratase, RhamD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
Protein: SODC1_BRAJU
Sequence: MGKGVRVLNSSEGVKGTIFFTQEGNGTTTVTGTVSGLKPGLHGFHVHALGDTTNGCMSTGPHFNPEGKTHGAPEDANRHAGDLGNITVGDDGTATFTITDSQIPLDGPNSIVGRAVVVHAEPDDLGKGGHELSLTTGNAGGRVACGIIGLQG
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn] 1.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_STRTD
Sequence: MKRQSALIVFSGGQDSTTCLFWALKHYEIVELVTFAYGQRHSLEIEVAKEIAQEQGLKHHVLDMSLLGQITENALTSDIDIEAEEGEVPNTFVDGRNHLFLSFAAVLAKQRGIIDIVTGVCETDFSGYPDCRDVFVKSLNVTLNLAMAYDFVIQTPLMWLDKAETWALADQLGAFDYVREKTLTCYNGIIGTGCGDCPACHLRQKGLEKYLAEKGDA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: GUAA_CERSK
Sequence: MTQHDRLLIIDFGSQVTQLIARRLRELNVYCEIHPYQNVTEAFLKGFAPKAVIFSGGPSSVFAEGAPMPPAGVFDLGVPILGICYGQQVMMHCLGGKVERGHGTAEFGRAFVTPTAERLAILDGWFEEGREQVWMSHGDHVSQIAPGFQVFGTSPNAPFAITGDPARHFYAVQFHPEVHHTPKGAKLYENFVRLAGFKGDWTMGAYREEAIARIRAQVGDQKVICGLSGGVDSSVAAVLIHEAIGDQLTCVFVDHGLLRLGEAEQVVKMFRDHYNMPLIHADESDLFLGALEGVSDPEVKRKTIGRLFIDVFQKHAADVGGATFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPEKMGLKLVEPLRELFKDEVRALGRELGLPESFIGRHPFPGPGLAIRCPGEITREKLEILRRADAVYIDQIRRHGLYDEIWQAFVALLPVRTVGVMGDGRTYDYACALRAVTSVDGMTADYYPFTHDFLGETATRIINEVQGINRVTYDITSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: GPC5_MOUSE
Sequence: MDARTWRLGWRCLLLLALLGSTRSEGVESCEEVRKLFQWRLGGAVKGLPEAPRAGPDLQVCLSKNPTCCTRKMEERYQIAARQDLQQVLQTSSSTLKLLISRNAAAFQETLETLIRQAENYTSILFCNTYRNMALEAAASIQEFFTDVGLYLFGADVNPEEFVNRFFDSLFPLVYNHLINPGVTDSSLQYSECIRMARQDVSPFGNIPKRVMGQMGRSLLPGRTFLQALNLGIEVINTTDHIHFSKECSRALLKMQYCPHCQSLMLSKPCMGYCLNVIRGCLAHMTELNPHWHAYIRSLEELSDAMHGTYDVEHVLLNFHLLVNDAVLQAHLNGQKLLDQVNTICGHPVRTPTQSPRCTFDPSKEKHGMKISARNGEETLANRRKEFINSLRLHGSFYGGLADQLCVNELAAPEGRPCWNGEEIVKSYAQRVVGNGIKAQSANPEVRVRGTDPVVNQIIDKLKHVIQLLRGRSPKPNKWELLQPGSGGGMLENSSGDCDDEDGCGGSGSGEVKRTLKITNWMPDSMNFSDVKQVHRADHGSTLDTTSTGCASGTESMALPLMGTLMFLPWLW
What is the function of this protein?
Cell surface proteoglycan that bears heparan sulfate.
What are the official names of this protein?
Glypican-5.
What is the protein family that this protein belongs to?
Belongs to the glypican family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side. SUBCELLULAR LOCATION: [Secreted glypican-5]: Secreted, extracellular space.
Protein: NFUA_PSESM
Sequence: MTAITITDAAHDYLADLLEKQNTPGIGIRVFITQPGTQYAETCIAYCKPGEEKPEDKAIGLKSFTAWIDGFSEAFLDDAVVDYATDRMGGQLTIKAPNAKVPMVNADSPINERINYYLQTEINPGLASHGGQVTLIDVVEEEAKNIAVLQFGGGCQGCGQADVTLKEGIERTLLERIPELSGVRDVTDHTQKENAYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: GSA_MYCTA
Sequence: MGSTEQATSRVRGAARTSAQLFEAACSVIPGGVNSPVRAFTAVGGTPRFITEAHGCWLIDADGNRYVDLVCSWGPMILGHAHPAVVEAVAKAAARGLSFGAPTPAETQLAGEIIGRVAPVERIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHVDALLADAGSGVATLGLCDDPQRPASPRSQSSRGLPSSPGVTGAAAADTIVLPYNDIDAVQQTFARFGEQIAAVITEASPGNMGVVPPGPGFNAALRAITAEHGALLILDEVMTGFRVSRSGWYGIDPVPADLFAFGKVMSGGMPAAAFGGRAEVMQRLAPLGPVYQAGTLSGNPVAVAAGLATLRAADDAVYTALDANADRLAGLLSEALTDAVVPHQISRAGNMLSVFFGETPVTDFASARASQTWRYPAFFHAMLDAGVYPPCSAFEAWFVSAALDDAAFGRIANALPAAARAAAQERPA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OCA2_YEAST
Sequence: MKYIPPLNFSPVVSTDVSLYRSGYPMPLNYSFIKHQLHLKTIIYIGDKDRPLEEYQSFLESEKIKYYHIFMDSSRDEGIQERMNQVLHLVLDVRNYPILVHSNKGKHRVGVVVGIIRKLLQGWSTAGICQEYGLFSGGMKDGVDLEFITMFETNLKIPRNVIPGFAKHCLYLNELEAAEGSDDESGSESILTAKQPI
What is the function of this protein?
Required for normal growth in the presence of linoleic acid hydroperoxide (LoaOOH).
What are the official names of this protein?
Tyrosine-protein phosphatase-like protein OCA2, Oxidant-induced cell-cycle arrest protein 2.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_PSEPK
Sequence: MHGESPIKRRESRKIWVGNVPVGGDAPIAVQSMTNTDTNDVAATVAQIQRLVDAGVDIVRVSVPDMDAAEAFGKIKQRVSVPLVADIHFDYKIALRVAELGVDCLRINPGNIGREDRVRAVVDAARDRGIPIRIGVNAGSLEKDLQKKYGEPTPAALVESALRHVEHLDRLDFQDFKVSVKASDVFMAVEAYRLLAKQIVQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRISLAADPVEEVKVGYDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPLDVAVIGCVVNGPGEAKEAHVGLTGGTPNLIYIDGKPAQKLTNDNLVDELEKLIRQKAAEKAEADAALIARG
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.