PharMolix/UniProtQA huggingface dataset:
Protein: SYT_SULNB
Sequence: MSENLIGYIDDQGNIIDTQSAGENCTARPIEFDNSEKSLEIIRHSTAHLMAQAIKELYPDAQFFVGPVVDEGFYYDFRVNEKIGEEDLKTIEKKMKELIKKKYKIEKYEISKDEALKKFANDDLKQAVLSRIPDETVSIYKQGDFEDLCRGPHVPALRFLHNFKLTRVAGAYLGGDENAEMLTRIYGIAFADKESLKSYLKMMEEAKKRDHRKIGTEMELFMFNEESGAGLPFWMPQGAKLRYKLEQILHKAHLVRDYEPVRGPEILKADMWRTSGHYACYGENMYLTEIDGQEYGIKPMNCIGHIQIFKQTQKSYRDLPVKYYEYGVVHRHEKSGVLHGLLRVREFTQDDAHIFCAPEQIASEVLEVVEFVDSVMKLFEFEYTMEISTKPEKAIGDDEVWETATQGLKDALKGNDLPYTIDEGGGAFYGPKIDIKITDAIGRKWQCGTIQVDFNLPERFDVEYVAEDNSRKRPVMLHRAILGSFERFIGILTEHYAGEFPFFIAPTQVIFVPISEGHAGYAYGLKKKLMLEGIDSEVSDKNDSLNKRIRTAEKQRVPYVVIIGDEEVQNNTVAIRNRRTREQYNLTQDEFMVELTKQLQEGKI
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABHGA_RAT
Sequence: MAKLLSCVLGPRLYKIYRERDTDRAATSVPETPTAVPAASSSSWDSYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLVLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSAENKRQLANYNFDFRSWPVDFHWEEPSSRKGSRGGPSRRGVALLRPEPLHRGTADTFLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIVIYAWSIGGFTATWAAMSYPDISAVILDASFDDLVPLALKVMPDSWRALVTRTVRQHLNLNNAEQLCRFQGPVLLVRRTKDEIITTTVPEDIMSNRGNDLLLKLLQFRYPRVMTEEGLRAVRQWLEASSQLEEASIYSRWEVDEDWCVSVLRSYQAEHGPDFPWSVGEDMSVDGRRQLALFLARKHLHNFEATHCTPLPAQHFQMPWCL
What is the function of this protein?
Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS).  LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity).  Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity).  Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (By similarity).
What are the official names of this protein?
Phosphatidylserine lipase ABHD16A, Alpha/beta hydrolase domain-containing protein 16A, Abhydrolase domain-containing protein 16A, HLA-B-associated transcript 5 homolog, Monoacylglycerol lipase ABHD16A.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. ABHD16 family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: SP0A_BACCR
Sequence: MEKIKVCLVDDNKELVSMLESYVAAQDDMEVIGTAYNGQECLNLLTDKQPDVLVLDIIMPHLDGLAVLEKMRHIERLKQPSVIMLTAFGQEDVTKKAVDLGASYFILKPFDMENLTSHIRQVSGKANAMIKRPLPSFRSATTVDGKPKNLDASITSIIHEIGVPAHIKGYMYLREAISMVYNDIELLGSITKVLYPDIAKKYNTTASRVERAIRHAIEVAWSRGNIDSISSLFGYTVSMSKAKPTNSEFIAMVADKLRLEHKAS
What is the function of this protein?
May play the central regulatory role in sporulation.  It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress.  Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.  Repressor of abrB, activator of the spoIIa operon.  Binds the DNA sequence 5'-TGNCGAA-3' (0A box) (By similarity).
What are the official names of this protein?
Stage 0 sporulation protein A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIM9_CAEEL
Sequence: MTSEQNIQTFRDFLTQYNLVAEQCFNSCVNEFGSRTVSGKEESCANNCLDKFLKMTQRVSQRFQEHQLLNAQANGAAIKVENGGKINKIQ
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim9.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: TRPF_PSEPG
Sequence: MSYVRSKICGITRIEDALAAAEAGADAIGFVFYAKSPRAVDVRQARAIITELPPFVTTVGLFVNASRCELNEILEVVPLDLLQFHGDETPQDCEGYHRPWIKALRVRPGDDLEAACKQYAGARGILLDTYVAGVPGGTGEAFDWSLVPAHLSKPIILAGGLSADNVGQAIAQVRPYAVDVSGGVEQAKGIKDAAKIEAFMRAVKQA
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RPOB_SINMW
Sequence: MAQTLSFNGRRRVRKFFGKIPEVAEMPNLIEVQKASYDQFLMVDEPQGGRPDEGLQAVFKSVFPIKDFSGASMLEFVSYEFEAPKFDVEECRQRDLTYAAPLKVTLRLIVFDIDEDTGAKSIKDIKEQNVYMGDMPLMTDNGTFIVNGTERVIVSQMHRSPGVFFDHDKGKSHSSGKLLFAARVIPYRGSWLDIEFDAKDIVHARIDRRRKIPVTSLLMALGMDGEEILDTFYTKSLYQRDGEGWRVPFQPDALKGQKALADLIDADTGEVVVEGGKKLTPRLLRQLQDKGLKALKATDDDLYGNYLAEDVVNFETGEIYLEAGDEIDEKTLPVILSAGFDEIPVLDIDHINIGAYIRNTLAADKNENRQDALFDIYRVMRPGEPPTMDSAEAMFNALFFDAERYDLSAVGRVKMNMRLDLDVPDTVRTLRKEDILAVVKMLVELRDGKGEIDDIDNLGNRRVRSVGELMENQYRLGLLRMERAIKERMSSIEIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQVNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATFARVNKYGFIESPYRKIVDGKVTSDVVYLSAMEEAKYHVAQANSVLDEDGSFSEEFVVCRHAGEVMLAPRDNINLMDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLLRAEAPFVGTGMEPVVARDSGAAIAARRGGIVDQVDATRIVIRATEDLDPSKSGVDIYRLQKFQRSNQNTCVNQRPLVTVGDVLNKGDIIADGPSTDLGDLALGRNALVAFMPWNGYNYEDSILLSERIVRDDVFTSIHIEEFEVMARDTKLGPEEITRDIPNVSEEALKNLDEAGIVYIGAEVQPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSMRMPPGTFGTVVEVRVFNRHGVEKDERAMAIEREEIERLAKDRDDEQAILDRNVYARLVDMLRGHVAVAGPKGFKKGTELSNAVISEYPRSQWWMFAIEDEKAQGEIEALRGQYDESKSRLEQRFMDKVEKVQRGDEMPPGVMKMVKVFVAVKRKIQPGDKMAGRHGNKGVVSRIVPIEDMPFLEDGTHVDVVLNPLGVPSRMNVGQILETHLGWACAGMGKKIGAMLDAYKAGADIQPLRDTIDSVIGSGPKGEPIKQYDDESIVRLAEQTRRGVSIATPVFDGAVEADVNEMLEQAGLKVTGQSTLYDGRTGETFDRQVTVGYIYMLKLNHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYEAIVRGDDTFEAGIPESFNVLVKEMRSLGLSVELENSKVDEVGASAQLPDAAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: 6PGL_SALPK
Sequence: MKQTVYTASPESQQIHVWSLNHEGTLTLVQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLAYRIAPDDGALTFAAESALPGSPTHISTDHHGRFVFVGSYNAGNVSVTRLQDGLPVELVDVVEGLDGCHSANITPDNRTLWVPALKQERICLFTLSDDGHLVAQEPAEVNTVEGAGPRHMVFHPNRQYAYCVNELNSSVDVWQLKNPHGEIECVQTLDMMPADFSDTRWAADIHITPDGRHLYACDRTASLITVFSVSEDGSVLSVEGFQPTEAQPRGFNIDNSGKYLIAAGQKSHHIAVYEITGTQGLLTEKGRYAVGQGPMWVVVNAY
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6-P-gluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: HUTH_STRPG
Sequence: MTRVINLDGESLTLEDVIAIARQGVACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAYYKGEFLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEENLHTIRPQSGQLATARNIRNLLEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDGHVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPASVDSIPSCENQEDFVSMGTTAARKAFEILKNSRRIVATEIMAACQALDLKPENHELGKGTKVAYDLFRKEVNFIEHDKHIEIYDELNKASTVIEDPSFLEAVEQAVELSIQF
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGBR3_MOUSE
Sequence: MAVTSHHMVPVFVLMSACLATAGPEPSTRCELSPISASHPVQALMESFTVLSGCASRGTTGLPREVHILNLRSTDQGLGQPQREVTLHLNPIASVHTHHKPVVFLLNSPQPLVWHVKTERLAAGVPRLFLVSEGSVVQFSSGNFSLTAETEERSFPQENEHLLHWAQKEYGAVTSFTELKIARNIYIKVGEDQVFPPTCNIGKNFLSLNYLAEYLQPKAAEGCVLASQPHEKEVHIIELISPNSNPYSTFQVDIIIDIRPAREDPEVVKNLVLILKCKKSVNWVIKSFDVKGNLKVIAPDSIGFGKESERSMTVTKLVRNDYPSTQENLMKWALDNGYSPVTSYTIAPVANRFHLRLENNEEMRDEEVHTIPPELRILLGPDHLPALDSPPFQGEIPNGGFPFPFPDIPRRGWKEGEDRIPRPKEPIIPRVQLLPDHREPEEVQGGVNIALSVKCDNEKMVVAVDKDSFQTNGYSGMELTLLDPSCKAKMNGTHFVLESPLNGCGTRHRRSAPDGVVYYNSIVVQAPSPGDSSGWPDGYEDLESGDNGFPGDTDEGETAPLSRAGVVVFNCSLRQLRSPSGFQDQLDGNATFNMELYNTDLFLVPSPGVFSVAENEHVYVEVSVTKADQDLGFAIQTCFISPYSNPDRMSDYTIIENICPKDDSVKFYSSKRVHFPIPHAEVDKKRFSFVFKSVFNTSLLFLHCELTLCSRNKGSQKLPKCVTPDDACTSLDATMIWTMMQNKKTFTKPLAVVLQVDYKENVPNMKESSPVPPPPQIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETARRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA
What is the function of this protein?
Binds to TGF-beta.  Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors (By similarity).
What are the official names of this protein?
Transforming growth factor beta receptor type 3, TGF-beta receptor type 3, TGFR-3, Betaglycan, Transforming growth factor beta receptor III, TGF-beta receptor type III.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Secreted. Secreted, extracellular space, extracellular matrix. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
Protein: RIBRX_MAIZE
Sequence: MPLPQPLLGGASPAPARAASSFLHPLLHTRHRVSTAPAAASSFVPASHSSHANDAMLLRRAADVADRSAGLTSPHPNFGCVIARPQLNTDSADSWVVGEGFLYAQGTPCAELLASQEAGEHARGGTAYLNLEPGDCFGDNTAVGSLVQAGITRVVVGLRHPLKHLRGKAIQALRNEGIQVDVVGEDLQSKLFKEALKSCLTVNAPLLYRAAFHVPFSVLKYAMTADGKIAASSGHASWISGKASRGRVFELRGRSDAVIVGGNTVRFDDPRLTARHVKGHVPVRIVMSQSLNLPEEANLWNLNDAYTIVATQRGARRDFQRKLAMKGVEVVEFDMLNPRAVMSYCYDRGYLAVLWECGGTLAASAISASVIHKVYAFWAPKIIGGLNAPTPVGELGMSQMTQAINLIDVSYEQIDRDMLMSGFIEPIPDLSPVIPSVEEIPSIDPEVSPYETNIISFYKTWDIFGAFSNFSPHSIQMPDENGDYFTWPTVEHYYQAHKFVGVDNPQARDIVQEIKLAKSPEEAARIGRTRQKGFPELVRTDWESTKIDVMYRAIKCKFSTYPHLTNMLLSTAGSVLVEASPHDLFWGGGREGEGLNYLGRLLMQLRSEILGTVPASAEVGEAD
What is the function of this protein?
Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products.  Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do.  Has no activity against GTP, nucleoside monophosphates or ADP-ribose.
What are the official names of this protein?
Riboflavin biosynthesis protein PYRR, chloroplastic.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the YbiA family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ISY2_NEPRA
Sequence: MSLSWWRAGAAKKRMDDDESLLVKQQQQQCVALIVGVTGLVGNSLAEMLPLPDTPGGPWKVYGVARRARPSWNEDQPMTYISCDVSNTGEVEAKLSPLSDVTHIFYATWTSRSTEEENCEANGKMLKNVLDAMIPNCPNLKHICLQTGRFHYVASVVDWKINGSHDTPLTEDLPRLKTNNFYYTQEDILLEEVKRKEGLTWSVHRPGTIFGFSPYSMMNLVGTLCVYAAICKQEGAVLRFPGCKGAWDGHSDCADADLIAEQQIWAALDPHAKNQAFNVSNGDLFKWKHLWKVLADQFGVECGDYEEGQQLRLQDVMKDKGPVWDKIVAENGLSNTKLEDVGKWWFSDTILWNECRLDSMNKSKEHGFLGFRNSKNCFLYWIHKVKAYNLVPSTYT
What is the function of this protein?
Iridoid synthase that catalyzes the first step in generation of the iridoid ring scaffold using the linear monoterpene (6E)-8-oxogeranial as substrate (PubMed:29091815).  Iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and antibacterial activities (Probable).  Catalyzes the conversion of the linear monoterpene (6E)-8-oxogeranial to (S)-8-oxocitronellyl enol, a precursor of nepetalactones, which are metabolites that are both insect-repellent and have euphoric effect in cats (PubMed:29091815).
What are the official names of this protein?
(S)-8-oxocitronellyl enol synthase ISY2, Iridoid synthase 2, NmISY2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: NATD1_BOVIN
Sequence: MAQSPAAASPGAPEQGCPIRVEHDRRRRQFTVRLNGCHDRAVLLYEYVGKRIVDLQHTEVPDAYRGRGIAKHLAKAALDFVVEEDLRAHVTCWYIQKFVKENPLPQYLERLQP
What are the official names of this protein?
Protein NATD1, N-acetyltransferase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the NATD1 family.
Protein: RL36_RUMCH
Sequence: MKVKPSVKTICEKCKIIKRKGRVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: CEP44_XENLA
Sequence: MATGDVKGCIRKLEQRLRTLNYPRDVDYTGLIKGDPSASLPIISYTFTCYSTSIAEILISFGIELTTKSDLRFIEAVYKVLRDVFNYKPILTKQQFLQCAFSERKIQIICDIVDCVVKKHKEITGQNKVKSQLVKKVVSAKDQCEVFYPEDVSVQPSVKTTQKKPLVERHAGSEFLLPTKCYSSALVEDIEEEEPTSDSEGGSHLEHEMESPFETAETTPNSEQIELLRKQLAECQEKLQRLDCVEQRLQSLETSMKGKIIIDETDWNNLLSRVLLLETEGLLQSKKTDFSVPSEFACISEQRTSSRMTNEICSNLKTKADIPESHHQSSGYSFVLSADTSPIAIDINYSSLTEDSNETTKQRMERITKMMEETSKLLKCSNNT
What is the function of this protein?
Centriole-enriched microtubule-binding protein involved in centriole biogenesis.  In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall.  Functions as a linker component that maintains centrosome cohesion.  Associates with CROCC and regulates its stability and localization to the centrosome.
What are the official names of this protein?
Centrosomal protein of 44 kDa, Cep44.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Localizes to the proximal end of mother and daughter centrioles.
Protein: NTD_LACLE
Sequence: MPKKTIYFGAGWFTDRQNKAYKEAMEALKENPTIDLENSYVPLDNQYKGIRVDEHPEYLHDKVWATATYNNDLNGIKTNDIMLGVYIPDEEDVGLGMELGYALSQGKYVLLVIPDEDYGKPINLMSWGVSDNVIKMSQLKDFNFNKPRFDFYEGAVY
What is the function of this protein?
Catalyzes the cleavage of the glycosidic bond of 2'-deoxyribonucleosides and the transfer of the deoxyribosyl moiety to an acceptor purine or pyrimidine base.
What are the official names of this protein?
Nucleoside deoxyribosyltransferase, N-deoxyribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside deoxyribosyltransferase family.
Protein: FGFR1_RAT
Sequence: MWGWRGLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVRDSIPADSGLYACVTNSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYDQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWNAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQDSPSFPDTRSSTCSSGEDSVFSHEPFPEEPCLPRHPTQLANGGLNRR
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration.  Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.  Phosphorylates PLCG1, FRS2, GAB1 and SHB.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2.  In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription.  FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).
What are the official names of this protein?
Fibroblast growth factor receptor 1, FGFR-1, bFGF-R-1, Basic fibroblast growth factor receptor 1, MFR, Proto-oncogene c-Fgr.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus (By similarity).
Protein: RL30_CLOBK
Sequence: MAKVKITLVKSLIGRKKDQIATVNALGLKKIGNIVEHEETPQISGMIKKVSYLLKVEEA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: DNLI4_CANGA
Sequence: MADEGGLETGAHDELKGTEEQAVNFAPSPDFLWLCEQLFAKIDHVQFERANNLLTKPVTARYYEVISNFTTLWRTTVGNNIYPALRLILPYRDRRVFNIKDYTLIKAICAFLKLPKDSSTEKKLINWKQDAGRSVRLSKFCVEEIKKRRSEPQIDRNERITIDDLNGYLDQLAIERTEQGRSFKNLANSDIMNKCLTSMTFLEMQYFFDILLKNRPLGGHEHKLLNCWHPDAQDYLSVVSDLETVAKRLWDPSQRLGNQDLKINIGLAFAPQLATKLHVSYQKIGEKLGWDFFIEEKMDGERIQMHYTNFGSDIKFYSRRATDYTYLYGNNLKTGTLANFINLNKNVKDCVLDCEVVTFDSNNKIVLPFGMVKSSAKNMLSQDGIDTQGFHPLLMVFDVLYLNGATLVDLPYYKRREYLKQILTPTAHRIEIIKSIRANDEQMIKKSLEKALSVGSEGIILKRYDSRYVIASRSDDWIKIKPEYLEQFGENMDLVLMGRDPSKKDSLMLGLLDYEEVIQDSPIMVNSQSSEENSQRFRGFVSLCIIANGISNEEYKEIDRKTKGLWNDSEKIPPLEYMKFGSKVPRQWIDPKKSLILEIKARSLDNTRSSERKFAAGCTLFGGYCRQIREDKNWKTCYTLQEFERAKSGNNWRKRGSSKPQKVISKKRRYNIISSVNKALEDFAELEHRSDIFDGMYFYVLSDYFDGVKRKRIKKSEIQKVIVANGGQLVQNVITRNYNLNDLRIISSRNTVECNSLIVRGYDIISPKWVFDCLLSGKIMKLEPSHCFNFSKQLMDYAYKRIDQYGDPYERDINKYEWSSLTSEKICTTAKQQPDVQFDNSLMDVPHFLFHGRIVFLLSDNNNIQKESFMVDAYGGKVTNELSSANLVIVVGAVTQRRINDIRKQISSEVIKQDHPPRIPDMVSEGWLYDCIKQNTQVAEDNYRLP
What is the function of this protein?
Involved in ds DNA break repair.  Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining.
What are the official names of this protein?
DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS10_GLAP5
Sequence: MQNQRIRIRLKAFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHKRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: BETB_ACIBC
Sequence: MSDVQVHQLYIHGRYVEATSGKTFNSINPANGEIIATLQQASEQDIEAAVKSAQQGQKIWAAMTAMERSRILRRAVDILRERNDELARLETLDTGKAYSETSTVDIVTGADVLEYYAGLATAIQGEQVPLRESSFFYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSETTPLTALKLAEIYTEAGLPDGVFNVVQGAGREIGQWLTEHPVIEKISFTGGVETGKKVMASAAGSTLKEVTMELGGKSPLIICEDADLNRAADIAVMANFFSSGQVCTNGTRVFVPKSRLADFEKAVVERVKRIRIGDPMAEDTNFGPLTSFPHMEKVLSFIESGKQQGAKVLIGGGRATEGELAKGAYVLPTVFSDCTDQMAIVQEEIFGPVMSILSYETEEEVIQRANDTTFGLAAGVVTQDISRAHRIIHQIEAGICWINTWGESPAEMPVGGYKQSGVGRENGLTTLGHYTRIKSIQVELGDYQSIF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: PACA_SHEEP
Sequence: MTMCSGARLALLVYGILMHSSVYGSPAASGLRFPGIRPENEAYDEDGNPQQDFYDSEPPGVGSPASALRDAYALYYPAEERDVAHGILDKAYRKVLDQLSARRYLQTLMAKGLGGTPGGGADDDSEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIPYL
What is the function of this protein?
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity).  Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity).  In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity).  Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
What are the official names of this protein?
Pituitary adenylate cyclase-activating polypeptide, PACAP.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: MTR1C_DANRE
Sequence: CHSLRYDRLYSRRNTCLYLLLTWMLTALATVPNFLVGSLKYDPRVFSCTFTQTASSSYTVCVVLIHFLVPLGVVSFCYLRIWTLVIRVKGRVRPNPKVRAADLRNFLTMFVVFVLFAVCWAPLNFIGLAVAINPAKVAPNIPEWLFVTSYF
What is the function of this protein?
High affinity receptor for melatonin.  The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).
What are the official names of this protein?
Melatonin receptor type 1C, Mel-1C-R, Mel1C receptor, Melatonin receptor Mel1C Z2.3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MGAT2_PIG
Sequence: MRFRIYKRKVLILTFVVAACGFVLWSSNGRQRKNEALAPPLLDAEPVRGAGARAGDHPAISVGIRRGSNDSAAPLVAAAPQPEVDNLTLRYRSLVYQLNFDQTLRNVDKVSSWVPRELVLVVQVHNRAEYLKLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVDFCPVLQVFFPFSIQLYPNEFPGTDPRDCPRDLEKNAALKMGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKVLRDYAGLILFLEEDHYVAPDFYHVFKKMWNLKQQECPECDVLSLGTYTTVRSFRDVADKVDVKTWKSTEHNMGLALTRDAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPKFWKVLVPQVPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNSNKQYMFPETLTISEKLTAALSPPRKNGGWGDIRDHELCKSYRRLQ
What is the function of this protein?
Plays an essential role in protein N-glycosylation.  Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.
What are the official names of this protein?
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, Beta-1,2-N-acetylglucosaminyltransferase II, GlcNAc-T II, GNT-II, Mannoside acetylglucosaminyltransferase 2, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 16 (GT16) protein family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.