PharMolix/UniProtQA huggingface dataset:
Protein: SPB1_CRYNB
Sequence: MGKHDKKTGKGRLDKFYRLAKEQGYRARSAFKLVHLNRKYDLLSKARCCIDLCAAPGGWLQVAEKYMPKGSLIIGVDLNAIKPLPHVTTFVADITTPHCRQTLRQHMHDWKADLVLHDGAPNVGSAWVQDAFTQNELVLQSLKLATEFLAKGGSFVTKVFRSQDYNSLLWVFGQLFKSVEATKPPSSRNVSAEIFVVCRDFIAPKHIDPKFLDPKHVFKDIASLPTSITEPTDTSIAPTSSSTASAAAAAARLAANSHAHSNVYAPEKKRRHREGYAEGDYTLHHTASAEEFVRGQDPVLLLGNMNKIEFRNETEKGWLKSRHTTPDIIANFEDLKVLGKGDFKALMKWRLAIRLEIGLDVKADKTQDATEEVVVEPMDEEEQITEELQKLQQAKLAKTKRERKRANEKKARELLKLQLNMTVPDDLDQNDLALQGEEEIFDLEEGENEARRRGKNGGLATLVDDGEGMDLASESEEEEDEDEEDDEVLDSDEERERKTAALEGELDGLYDSYVERKKERDAKWKVKQDRLKDKNFDAWHGIQEKSDEEGSDDDDGQDDDEEGGWDVIAQKKAKYGEGDSSDSDSDAEPETEVPKKIKKVSFEKPARSEKSSGLMTSLREPELRAQRSKQAQLWFDQPVFKEVGDLAALDGDDEEEEEEDESEEEESDDEDVDMEDASESSSTLEGDDDFEIVPQAPEDDGPEWDVDDEDQDEVKKKVIQDKGLLTAEAVSLATALVNRKTTADKLIDQGFNRLSAHNKDGLPTWFLDDESQFYKPNIPITKEAVDALRARQRALDARPIKKVAEAKGRKKMKAVARMEKAKKKADGVMESEEMGDGEKARQVRRMLARAAKGKEKAKEKKIVVAKGVNKGVKGRPTGVKGKYKIVDARMRKEVRALKRIKKAGSKRR
What is the function of this protein?
Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
AdoMet-dependent rRNA methyltransferase SPB1, 2'-O-ribose RNA methyltransferase, S-adenosyl-L-methionine-dependent methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RECF_STAA1
Sequence: MKLNTLQLENYRNYDEVTLKCHPDVNILIGENAQGKTNLLESIYTLALAKSHRTSNDKELIRFNADYAKIEGELSYRHGTMPLTMFITKKGKQVKVNHLEQSRLTQYIGHLNVVLFAPEDLNIVKGSPQIRRRFIDMELGQISAVYLNDLAQYQRILKQKNNYLKQLQLGQKKDLTMLEVLNQQFAEYAMKVTDKRAHFIQELESLAKPIHAGITNDKEALSLNYLPSLKFDYAQNEAARLEEIMSILSDNMQREKERGISLFGPHRDDISFDVNGMDAQTYGSQGQQRTTALSIKLAEIELMNIEVGEYPILLLDDVLSELDDSRQTHLLSTIQHKVQTFVTTTSVDGIDHEIMNNAKLYRINQGEIIK
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP100_CHLRE
Sequence: MPIYDEASVPGTAAGRSTTDVGATAGANPFNIPADEEIFRFREEERARKEQDKLIAQTMRVADKTTFAAQMQATATADARTLLRELRPPKGPKATTTLAASSVGTLDRRKEKENMADFIAKKREIFLLQMSLDTKRAEIKKLEERARQREEALKKSEQMLEEDALRFDAFLKENDEKVQEAIKKAEAEAKAKQDKVLEIKRLNTATAALRSELNKYEEQLEDCRRYKEFLDSITPPEWFEQQAAKLQRRKDALVAEWQSQCEALKQRREAALAAKTAAESDYANARTQQQAERAERAIKESVAALKEIMKEKEPQPPNLDFEMDPEDEEMYFQEPGQLLAVYKQLEESNLFYIQNAQETEEALEELRQKLRDTKTRMDAEAQGLQGQVSTLQASIVAAREKAKRLKDRTLENEGAFTLSMGSSNAPTSSVTGSSGPGGPVNLKELGDKVREVYVRCGFDADASISTLQMLTNIEMKLEEYLNLAEGMTPDYVDGAEKAREKDRRKVARDEKLSTQHREHEARMARALERAAAPVFKKTGKPLMFRSAPPQRKKVVQADDRNDEEAELEAYLAQDMI
What is the function of this protein?
As part of MIA, a complex associated with the outer doublet microtubules of the axoneme, may play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.
What are the official names of this protein?
Cilia- and flagella-associated protein 100, Flagella-associated protein 100, Modifier of inner arms 1 protein, Mia1p.
What is the protein family that this protein belongs to?
Belongs to the CFAP100 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, flagellum axoneme. Note=Localizes to the outer doublet microtubules of the axoneme.
Protein: VGLL1_MOUSE
Sequence: MEEMKKNGVWIPESSQKPVKTEWNAGSVIFTYFEGDINSMVDEHFSRALRNLKRPHKCSSSSHSDNLTLKNGVNKTRTDTSHTDRERKVESSQTENSGELKDVPVEEKGTNKSMPPNQRHLSSWTIAQPAASPENGARSSSLDEYGLKAMDQHSLSMPKTPSALPLEPWHFSSLARPGFIAPAYFPVFPDRHLTPEVYRVFPDRHLTPEVYHVFPDRHLTPEVYPDGRCGPLQHLVQQDRYQNHPLEPAARENCSPAKIAGSTGSLMNLPPYPVHYKKKICARGAASASLDDERSPSPKRRRDAYYY
What is the function of this protein?
May act as a specific coactivator for the mammalian TEFs.
What are the official names of this protein?
Transcription cofactor vestigial-like protein 1, Vgl-1, Vestigial-related factor.
What is the protein family that this protein belongs to?
Belongs to the vestigial family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDS_ORYSJ
Sequence: MDTGCLSSMNITGTSQARSFAGQLPTHRCFASSSIQALKSSQHVSFGVKSLVLRNKGKRFRRRLGALQVVCQDFPRPPLENTINFLEAGQLSSFFRNSEQPTKPLQVVIAGAGLAGLSTAKYLADAGHKPILLEARDVLGGKIAAWKDEDGDWYETGLHIFFGAYPNIQNLFGELGINDRLQWKEHSMIFAMPNKPGEFSRFDFPETLPAPLNGIWAILRNNEMLTWPEKVKFALGLLPAMVGGQAYVEAQDGFTVSEWMKKQGVPDRVNDEVFIAMSKALNFINPDELSMQCILIALNRFLQEKHGSKMAFLDGNPPERLCMPIVDHVRSLGGEVRLNSRIQKIELNPDGTVKHFALTDGTQITGDAYVFATPVDILKLLVPQEWKEISYFKKLEKLVGVPVINVHIWFDRKLKNTYDHLLFSRSSLLSVYADMSVTCKEYYDPNRSMLELVFAPAEEWVGRSDTEIIEATMQELAKLFPDEIAADQSKAKILKYHVVKTPRSVYKTIPDCEPCRPLQRSPIEGFYLAGDYTKQKYLASMEGAVLSGKLCAQSVVEDYKMLSRRSLKSLQSEVPVAS
What is the function of this protein?
Converts phytoene into zeta-carotene via the intermediary of phytofluene by the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene with a concomitant isomerization of two neighboring double bonds at the C9 and C9' positions from trans to cis.
What are the official names of this protein?
15-cis-phytoene desaturase, chloroplastic/chromoplastic, Phytoene dehydrogenase, Phytoene desaturase.
What is the protein family that this protein belongs to?
Belongs to the carotenoid/retinoid oxidoreductase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, chromoplast. Membrane; Peripheral membrane protein.
Protein: PEX14_DICDI
Sequence: MDNDDINNNNNNNNNNNNNNNSQELDQQEQTQEEITKQRIQKRKEEAKRIMEERKKREQQPPSQRQYEDVEDDQQQQPIRPIKQLPQRQQQYDDNDEPPQQQQYEPKISQRKVPLPPMKQPTTSSTASAATGSILSPSSNFREDMVKKAVLFLNNPNVKNTALARKVAYLEKKGLTSDEVKEALKRVETGNINGSSTNNSNITQSNSISRTRNDNYGNNNNNSSNNNNNIQQQQYYQQQQQQHQQQQQMALTQIQSYQKRLEADDQRIAQLMMNNNRFSWNSFLFSVTAIVGAASGLAYLTSNYIIPFLNGGKTNKDASANMDKKITSLQEEIIKLQSTIIQQGNDFRESTKSLKTLIEQQQQQILQQQQINSVSTTTNSATSASNSSEIVEIKKELKNLINLIGNKENSNNSNNNSNNSNNNNGYSKYNGFNGVYNKSSYDDVSTNNNNKTNSPPSPNKPTTTTTTTATSTPGSNISNTNKTLPPIIKTNPYSHLSWKLPTDQPPVIPSWQQKSSNPPSDLSNANDKSSPSNSNPSTPTKPYQSSFNYGDVNSFVGGSNTLNFDEKPTTTTTTSTTPSNERPSSPSVNNNNNNNNNNNNNNNNNNNNNNNTTIASTSNESNNSKVETTSNDSDKSTSPSSSSNNTTSTTATTTTITSASTEDNKQQSDETPYSSDFLDVINQLKQGKTPPGIRTDIDDKPLENSTVTKSAKERPKKPWERDTLTSVTNNLSVEETQTINNTDSSVEK
What is the function of this protein?
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity).  The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity).  Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (By similarity).
What are the official names of this protein?
Peroxisomal membrane protein PEX14, PTS1 receptor-docking protein, Peroxin-14.
What is the protein family that this protein belongs to?
Belongs to the peroxin-14 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: FAR2_PANRE
Sequence: SADPNFLRF
What is the function of this protein?
Myoactive.
What are the official names of this protein?
FMRFamide-like neuropeptide PF2, SADPNFLRF-amide.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: UREG_CENSY
Sequence: MGRVPRVGIGGPVGAGKSMLIERVVPVLAARGYHVSIVSNDVISKEDADRMRASLATERGLLPEDLVVGVATGGCPHTAVREDPSMNISIIEEIEAGHPELDLVIIESGGDNITTTFSPALADYFIYMIDVAGGDKYPRKGGLGIESCDLLLINKTDLAGMVGADLGVMRADAERIRGERPFGFVNCMTDEGITEVAERIIHDALLGAPPGHPVG
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_CARHZ
Sequence: MSEIREVIAREILDSRGNPTVEVDVILEDGTWGRAAVPSGASTGAFEAVELRDNDPQRYLGKGVTQAVENVNSIIGPEILGFDALDQVGIDEYLIELDGTPNKGKLGANAILGVSMAVAKAAANYLGLPLYRYLGGTNARVLPAPMMNILNGGKHADNNVDIQEFMIMPLGASSFSEALRMGAEVFHNLKKVLKGKGYNTAVGDEGGFAPNLKSNEEAIEVIVEAIEKAGYTPGKDIYIALDVAATELYKDGFYVLEGEGVKKSAAEMVEYYEKLCAKYPIISIEDGMSEEDWDGWKLLTERLGKKIQLVGDDLFVTNVERLQKGIDLGVANSILIKLNQIGTITETLNTIELARQNGYTTIISHRSGETEDTTLADLAVAVNAGMIKTGAPSRTDRVAKYNQLLRIEEELDYTAIYKGLKAFYNIKA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: MGLC_HAEIN
Sequence: MSALEKNKSFDLLKQNAIYFVLLILLGIIIAQDPTFLNLVNFSNILTQSSVRLIIALGVAGLLITQGTDLSAGRQVGLAAVISATMLQSMENINRVFPEMGQIPIPVVILAVCAIGAVIGLVNGLVIAYLNVTPFIATMGTMIIIYGFNSLYYDAVGGSPIAGFSENFSTFAQGFFRVGSFKLSYITIYAAIAALLVWIMWNKTRFGKNVFAIGGNPEAAKVSGVNVARNLVAIYMIAGMFYAFGGMLEAGRIGSATNNLGFMYELDAIAACVVGGVSFAGGVGTVIGVITGVIIFTVINYGLTYIGVNPYWQYIIKGSIIILAVAIDSLKYAKKK
What is the function of this protein?
Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Galactose/methyl galactoside import permease protein MglC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IFNA3_CANLF
Sequence: MALPCSFSVALVLLSCHSLCCLACHLPDTHSLRNWRVLTLLGQMRRLSASSCDHYTTDFAFPKELFDGQRLQEAQALSVVHVMTQKVFHLFCTNTSSAPWNMTLLEELCSGLSEQLDDLDACPLQEAGLAETPLMHEDSTLRTYFQRISLYLQDRNHSPCAWEMVRAEIGRSFFSLTILQERVRRRK
What is the function of this protein?
Produced by macrophages, IFN-alpha have antiviral activities.  Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
What are the official names of this protein?
Interferon alpha-3, IFN-alpha-3.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: FAR7_ASCSU
Sequence: AGPRFIRF
What are the official names of this protein?
FMRFamide-like neuropeptide AF7.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACOX4_CANMA
Sequence: MTFTKKNVSVSQGPDPRTSIQTERANSKFDPVTMNYFLEGSKERSELMKSLAQQIERDPILFTDGSYYDLTKDQQRELTVLKINRLSRYREGDSVDTFNKRLSIMGVVDPQVATRIGVNLGLFLSCISGNGTAEQFKYWAIDKGTHNIQGLYGCFGMTELGHGSNVAGVETTATFDKETDEFVINTPHIGATKWWIGGAAHSATHCSVYARLVVDGKDYGVKTFVVPLRDSNHDLMPGVTVGDIGAKMGRDGIDNGWIQFSNVRIPRFFMLQKFCKVSAEGEVVLPPLEQLSYSALLGGRVMMVLDSYRMLARVSTIALRYAIGRRQFKGDNVDQNDPNALETQLIDYPLHQKRLFPYLAAAYVVSTGALKVEHTIQSTLATLDAAVENNDTTAIFKSIDDMKSLFIDSGSLKATTTWLAAEAIDQCRQACGGHGYSSYNGFAKAFNDWVVQCTWEGDNNVLSLSVGKPIIKQIIGIEDNGKTVRGSTAFLNQVKDFTGSNASKVVLNNTSDLNDINKVIKSIEVAIIRLAHEAAISVRKESLDFAGAELVQISKLKAHHYLLTEFVKRVGEFEHKELVPFLNTIGRLYSATVVLDKFAGVFLTFNVASPQAITDLASTQIPKLCAEVRPNVVAYTDSFQQSDMVINSAIGKYDGDVYENYFDLVKQLNPPKNTKAPYTAALEGMLNRPSLEARERYEKSDETAAILSK
What are the official names of this protein?
Acyl-coenzyme A oxidase 4, AOX 4, Acyl-CoA oxidase 4.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA oxidase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: PGK_THISH
Sequence: MSVIKMTDLDLAGKRVLIREDLNVPVKDGKVTSDARIRASLPTIEHAMKAGAKVMLMSHLGRPEEGVFSEEDSLKPVAEHLSGLLGKEVRLVRDYLDGVDVADGEVVLLENVRFNKGEKKNEEGLSRKYAALCDVYVMDAFGTAHRAQASTHGAGQYAPVACAGPLLAAELEALGKALDNPKRPLVAIVGGSKVSTKLTVLESLSKVVDQLIVGGGIANTFIAAQGHPVGKSLYEADLVDEAKRLMAAAKAKGGDIPVPTDVVTGKEFSESTPASTKRVSEVAADDMIFDVGPDTAASYADMLRKAGTIVWNGPVGVFEFDQFAAGTKALGEAIADSDGFSIAGGGDTLAAIDKYGLASRISYISTGGGAFLEFLEGKKLPAVAMLEERAKG
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_STRP7
Sequence: MTKGILGKKVGMTQIFTEAGELIPVTVIEATPNVVLQVKTVETDGYNAIQVGFDDKREVLSNKPAKGHVAKANTAPKRFIREFKNVEGLEVGAEITVETFAAGDVVDVTGTSKGKGFQGVIKRHGQSRGPMAHGSRYHRRPGSMGPVAPNRVFKGKNLAGRMGGDRVTIQNLEVVQVVPEKNVILIKGNVPGAKKSLITIKSAVKAGK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PSBF_TRIEI
Sequence: MTSQNPNQPISYPIFTVRWLAVHTLGVPTVFFLGAIAAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RS13_METFK
Sequence: MARIAGVNIPNHKHTEIALTSIYGVGRTTAKQICLAAGVSATAKIKDLNDAEVEKLRDEVAKLQVEGDLRREVTMNIKRLMDLGCYRGIRHRRGLPVRGQRTKTNARTRKGPIKPIKASK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: FLHD_SHIBS
Sequence: MGIMHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITQLTQDSRVNDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMJ_HAEI8
Sequence: MAHSQVGIQLISESTEKTLAELIALCAEHNIIHNEKSPLALVQTDDRLELRKLDEPKLGAVYVDFVGGTMAHRRKFGGGRGEAVAKAVGIKGSALPTVIDATAGLGRDAFVLAAIGCQVRLVERHPVVFLLLQDGLNRAYQDEEIGEMLQQNLHLLNVQHINELDPNSDYADVVYLDPMYPHKQKSALVKKEMRVFQHLVGADLDADELLLPALQLAKKRVVVKRPDYAEFLCGKQPHFSRETKNHRFDIYMGASQC
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARHG8_MOUSE
Sequence: MEPEPAAQKQPRPRRRSRRVSMLSEEPAAGLPADTPGPAANERCSLRRGSSFTFLTPGPHWDFTLKRKRREKDDDAVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKSFSRSTVPTPTKRRSSALWSEMLDINMKESLTTREIKRQEAIYELSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDAYIPLHEDLLARIGEATKPDGTVEQIGHILVNWLPGLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHTPKDHRDVQLLEEAILIIQGVLSDINLKKGESECQYYINKLEYLDEKQKDPRIEASKVLLCHGELKNKSGHKLYIFLFQDILVLTRPVTRNERHLYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFGNSDKAKNIFRVRFQDPSPGHSHTLQANDVFHKQQWFNCIRAAIAPFQRAASPLELQGLPDLHEECEENNPSAGNLRAQRRSCVVPGVMQIDEESALDCGSSVQTVEDTRNMKAQRPQPGLRRARDKAQSGGKKKETLV
What is the function of this protein?
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.  May be involved in activation of the SAPK/JNK pathway.  Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
What are the official names of this protein?
Neuroepithelial cell-transforming gene 1 protein, Rho guanine nucleotide exchange factor 8.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: COQ4_ARATH
Sequence: MIIERARVPLSRWQQAAVAMGSALGALVDPRRADLIAALGETTGKPAFEMVLERMKKSEEGRAILLERPRVVSEQVGHAWDLPENTFGAAYAKFMGSRNFSPDDRPPVRFMETDELAYVATRAREVHDLWHTLFGLPTNLIGESSLKVIEFEQMYLPMCMLSVIGGTVRFNEKQRSMFLKHYLPWAVRAGRQCTDLMCVYYERHFSEDLEQVRRKWGIIPAPQHPK
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial, Coenzyme Q biosynthesis protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: LONB_THEAC
Sequence: MEENIESVEEWVNKLDIETTKDIHVPKLLFDQVIGQDQAGEIVKKAALQRRHVILIGEPGTGKSMLAQSMVDFLPKSELEDILVFPNPEDPNKPKIKTVPAGKGKEIVRQYQIKAEREKRDRSRSIMFVIFSVVLLGIIAAIVLRSITLIFFAIMAAAFLYMAMAFNPVIRNERAMVPKLLVSHNPNDKPPFVDSTGAHSGALLGDVRHDPFQSGGLETPAHERVEAGNIHKAHKGVLFIDEINLLRPEDQQAILTALQEKKYPISGQSERSAGAMVQTEPVPCDFVLVAAGNYDAIRNMHPALRSRIRGYGYEVVVNDYMDDNDENRRKLVQFIAQEVEKDKKIPHFDKSAIIEVIKEAQKRSGRRNKLTLRLRELGGLVRVAGDIAVSQKKTVVTAADVIAAKNLAKPLEQQIADRSIEIKKIYKTFRTEGSVVGMVNGLAVVGADTGMSEYTGVVLPIVAEVTPAEHKGAGNIIATGKLGDIAKEAVLNVSAVFKKLTGKDISNMDIHIQFVGTYEGVEGDSASVSIATAVISAIENIPVDQSVAMTGSLSVRGDVLPVGGVTAKVEAAIEAGLNKVIVPELNYSDIILDADHVNKIEIIPAKTIEDVLRVALVNSPEKEKLFDRISNLINAAKIIKPQRPATPATTRAGNNAA
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Degrades polypeptides processively.
What are the official names of this protein?
Archaeal Lon protease, ATP-dependent protease La homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family. Archaeal LonB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y3541_BRASB
Sequence: MLICIPDVLSKDEVAEFRRIMDAAEWEDGRSTAGAQSAMVKRNEQLPPDGEAARMLGQRIITALTRNPRFLSAAVPLQIFPPLFNRYTASRGDHFGIHVDNAVRGDPLTGLRIRTDLSMTLFLAEPDTYDGGELVIEDTYGSHEVKLPAGHAVLYPSSSLHMVTPVTRGARVASFFWMQSMIRDAHVRSMIFDLDTAIQSLTERLGRDDPDAVKLTGIYHNLIRQWAEV
What are the official names of this protein?
PKHD-type hydroxylase BBta_3541.
Protein: NODJ_SINFN
Sequence: MWKRYAAVLPANPWNWIAVWRRNYMAWKKAAIASILGNLAEPVTSLFGLGFGLGAMVGRVDGIPYVAFLAAGMVATSAMISATFETIHATFARMQAKRTWESALCTQLTLGDIVLGELAWAASKALLAGTAMMLVAATMGFASWPSVLFALPVIALTGFAFASLAMIVTALAPGYDYFIFYQTLFLTPMLFLSGAVFPVSQLPDIFQKLSHLLPLAHSIELIRPAMLDRPGGGVALHISALCIFAVMPFFLSVGLLQRRLLS
What is the function of this protein?
Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction.  Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide.  This subunit encodes the transporter (By similarity).
What are the official names of this protein?
Nodulation protein J.
What is the protein family that this protein belongs to?
Belongs to the ABC-2 integral membrane protein family. Lipooligosaccharide exporter (TC 3.A.1.102) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BBS2_RAT
Sequence: MLLPVFTLKLRHKISPRMVAIGRYDGTHPCLAAATQAGKVFIHNPHMRSQHFSTSRVFQSPLESDVSLLNINQTVSCLGAGVLNPELGYDTLLVGTQTSLLAYDIYNNSDLFYREVADGANALVLGTLGDIAPPLAIIGGNCALQGFDHEGNDLFWTVTGDNVHSLALCDFDGDGKSELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNHAMSIHAFDINSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAVAGVVEGDYRMDGHVQLICCSVDGEIRGYLPGTAEMKGNLLDTSVEQGLIRELSQKKQNLLLELRNYEENTKAELSSPLNEADGQKGIIPANTKLHTALSVNLGNDAQDAHAELRISTSNDTIIRAVLIFAEGIFAGESHVVHPSTHNLSSSIRVPITPPKDVPVDLHLKTFVGYRSSTQFHVFELIRQLPRFTMYALTSPDAASEPVSFVNFIVVERAQRMVTWLNQNFLLPEDSNIQNAPFHVCFTSLRNGGQLYIKMKPSGEITVNTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLLKVDEYHSVHQKLSANMADNSNLIRSLLVRAEDARLMRDMKTMKTRYMELYDLNKDLLNGYKIRCNNHTELLGNLKAVNQAIQRAGRLRVGKPKNQVISACRDAIRSNNINTLFRIMRVGTAPS
What is the function of this protein?
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  Required for proper BBSome complex assembly and its ciliary localization (By similarity).
What are the official names of this protein?
Bardet-Biedl syndrome 2 protein homolog.
What are the subcellular locations of this protein?
Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.