PharMolix/UniProtQA huggingface dataset:
Protein: DAAF5_MOUSE
Sequence: MAAPAEAEVAAAPGLTEAAEAAELTRALSRLLPGLETESKLGRRRALEALEQVLEEAVRPGADSAAFQGPWARLLLPRLLRLLSDPAEGCRALAAHLLDLGLRRAARPRDALPRLLPALSARLARPELARPPPEPCEELRLALVQLLHLAVDLGGAALAPHLDDAVRALRAALLDPFAAVRREGCECAAALARATPEHFHMQSESLIGPLMQTISHQHWKVRVAVIEATGTVIQFGSGNSVDDVLSHFAQRLFDDVPQVRQAVTSVVGGWLLNLRDRYSFLHKLTPLLLSSFSDEMPEIRQTATSLWEKVGLQWQQENEADLKDKLDFASPPPPNYPEHESRPGLGCRELVFRNLSKVLPAICHDITDWVVGTRVKAAQLLPVLLLHAEDHITQHLEIVLRTLHQACTDEEKAVVGSCIRAAELIGTFVSPEVFLKLILAMLKKAPSASGLLILASVIRGCPRNALQPHVTVIATELAQEHICQGSENNLYLEHLLLCVQALLSVCQEDCRAASLQFLEVLVTIMAVSDAVGLEKKAQKTMDTLAEVEDIPSSQDLYRKHVGALLERLTASHGEWAVHSVQLLKFTVLLTQAGPAVGEALQHVIPTLRACLQPSTDPHMRLKLFSILSMMLLRPKDTVDSQGQFRGYLDMVINDILAPNLQWHAGRTAAAIRTAAISCLWALISSDILSAKQVQEAQETLMPQVLATLEDDSQTTRLMSCRIINMFLKNSGDTMEPEKFLKVYPELLKRLDDVSNDVRMAAASALLTWLKCIESLDGKSAYQSSVQFLYRELLVHLDDPESAIQDTVLEVLKEGSVLFPDVLVRETEAVVHKHRSATYCEQLLQHMQTMAAAR
What is the function of this protein?
Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium.  It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility.
What are the official names of this protein?
Dynein axonemal assembly factor 5, HEAT repeat-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the DNAAF5 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic granule. Note=Observed only in the cytoplasm of ciliated cells and absent from cilia.
Protein: NAGZ_ECO5E
Sequence: MGPVMLDVEGYELDAEEREILAHPLVGGLILFTRNYHDPAQLRELVRQIRAASRNHLVVAVDQEGGRVQRFREGFTRLPAAQSFAALLGMEEGGKLAQEAGWLMASEMIAMDIDISFAPVLDVGHISAAIGERSYHADPEKALAIASRFIDGMHEAGMKTTGKHFPGHGAVTADSHKETPCDPRPQAEIRAKDMSVFSTLIRENKLDAIMPAHVIYSDVDPRPASGSSYWLKTVLRQELGFDGVIFSDDLSMEGAAIMGSYAERGQVSLDAGCDMILVCNNRKGAVSVLDNLSPIKAERVTRLYHKGSFSRQELMDSARWKAISARLNQLHERWQEEKAGH
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIFE_ECO57
Sequence: MAESFTTTNRYFDNKHYPRGFSRHGDFTIKEAQLLERHGYAFNELDLGKREPVTEEEKLFVAVCRGEREPVTEAERVWSKYMTRIKRPKRFHTLSGGKPQVEGAEDYTDSDD
What are the official names of this protein?
UPF0438 protein YifE.
What is the protein family that this protein belongs to?
Belongs to the UPF0438 family.
Protein: SYGB_PEDPA
Sequence: MAHNYLLEIGLEEIPAHVVTPSIKQLVQKVTAFLKENRLTYDSIDHFSTPRRLAIRINGLGDQQPDIEEDAKGPARKIAQDADGNWTKAAIGFTRGQGLTVDDITFKTIKGTDYVYVHKLIKGKMTKEILTGLKEVVESINFPTMMKWANFDFKYVRPIRWLVSILDEEVLPFSILDVTAGRRTEGHRFLGEAVELANAEEYEAKLHDQFVIVDADERKQLISNQIKAIAESNRWNVTPNPGLLEEVNNLVEWPTAFNGGFDEKYLAIPEEVLITSMRDHQRFFFVRDQAGKLLPNFISVRNGNEEFIENVVRGNEKVLTARLEDAAFFYEEDQKHDINYYVDRLKKVSFHDKIGSMYEKLQRVNSIAKVIGNTLNLNQTELDDIDRATMIYKFDLVTGMVGEFSELQGVMGEKYAQLNGENQAVAQAIREHYMPNSAEGDLPESVTGAVVALADKFDNIFSFFSAGMIPSGSNDPYALRRHAYGIVRILNSRDWQLDLNQFKSQVKTELAENGTAFGVDVDQNFDQVLNFFNDRIKQLLDHQKISHDIVETVLTGNNHDVTEIIEAAQVLADAKASSTFKDDIEALTRVQRIATKNEESGELNVDPQLFNNASEGELFDQIIKIEAANNLTMSQLFAKLCELTPAISKYFDATMVMDKDENIKRNRLNMMSRLANLILKIGDLTNVLVK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCAT1_ORYSJ
Sequence: MDLLRRVAVVAVLLSLPSRGRSGGGGSDLHPVVLVPGYGSNRLYARLTAAYEPAAPRCGAREGKDEWFQLWPIDAAASEPAQAPCLAEKMSLVYDPVADDYRNVAGVVTRVPSFASTRALVGWDPLVRQLEAMGHRDGGSLFAAPYDFRYAVAPRGHPSAVGERYFARLTRLIERASRLNGGRPAVVVAHSFGCALTYQFLRARPLAWRQRFVKHAVLLAAALGGFAEGMDGLASGAGSGLPNLAPPARARLARSQQSALWRLPTPMVFGDRPVVVTKNSTYSANNITEFLDAIGFTEGVQPYVTRVLPMWRALPAPMVPVTSMYGVGVRTPETFVYGEAGFEGTPEVVYGDGDGNMNIVSLMAAEEWSGVEGQILKVVRLPGVSHVGFFSDLALKKVVAEIQKAVSSIEVHRKEKIFSFLNNFEFTIPVPLGW
What are the official names of this protein?
Lecithin-cholesterol acyltransferase-like 1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
Protein: RUVB_CHLAA
Sequence: MSAERLVNPHSDSDDQQVEKSLRPRTLSEFIGQEKVVEQLRIAIAAARGRNESLDHTLFYGPPGLGKTSLANVVANEMGAKIKITSGPAIERAGDLAAILTNLQANDVLFIDEVHRLNRAVEEVLYPAMEDFALDLVVGKGPGARSLRLNLPRFTVIGATTRLALLTSPLRDRFVAVHRLVFYSDDAMTEIVSRSARILGVPISPEGAREIGRRARGTPRIANRILRRVRDYAQVVADGAITLQVARDALAQLEIDELGLDENDRRLLRAIIELFNGGPVGLSTLAAALAEEVDAIEDVYEPFLLQLGFLQRTPRGRIATRRAYEHLGLPYPERTLPADDESGPQQATLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ADDB_STRS7
Sequence: MKLLYTEISYSMTEILVKEARAYADKGYRVFYIAPNSLSFEKERSVLALLPEQGSFAITVTRFEQMARYFTLAKAANRQALDDNGLAMIFYRVLMQLQEDELKVFHRLRTDQAFIAQLVELYKELQAANLTAFDLTTLDRPEKQEDLITIMTKAEQLIAQGDYDQSSRLAQLAEAIKSKSLDDELRQTVLVIDGFTRFSAEEEQLLALLNEACEEIVIGAYISQKAYRLAFTKGNLYEASLAFIQQLAQQFQTKPIYTTSEKVFDVSFSRLTQLLEANHDYSKLDWQLSAKDKSKVVIWQALNQKEELEYVAKAIREKLYQGYRYKDMLVLLGDVASYQLQIGPIFEKFEIPYYIGKQEPMSAHPLVQFVESLERGRRYNWRREDIVNLLKSGLFGRFQEGELDQLEQYLVFADIQGFTKFSRPFTLNSSRQYPLPLLNQLRLAVVTPLQQLFKSQKQLGASLLDKLMTFFKTIQLADNFEALAGSRREADREKDEEVWKAFTGILETFYQVFGQEKMTLADCLALIKMGMQTAHYRTVPATLDVVSIKSYDLVEPHSKPFVFAIGLSRSHFPKQTKNTSLISDQERASINEQTASYQRLDVPSFENIKKNHQTALSLFNAATQELVLSLPTSLTNSSDDVSPYLKELIALGVPVIEKGKNRLSHSAADIGNYKALLSRLVAINRQGIADDMTSEDRNFWTVALRYLKRRLADEQLSLPAFEHHLTTKPVAPEVIETRFPSHQPLSLSSSALTVFYNNQYKYFLKYVLGLQEPESIHPDARIHGQYLHRIFELVTKDRTDAAFDQKLGAAIAAVNQQSAFQQVYQADAEGRYSLEVLKGIAYSTAPVLNLNQGMQVAKQEEAFELALGHQALIRGVIDRIDQLADGRLGIVDYKSSARVFDIGAFYNGLSPQLVTYLAALKNKGQGLFGAMYLHMQEPRLSLSDFKVLDDQLVAAAYKELTYKGIFLAQAKEYLANGSYHLNNTLYETDELETLLAYNEQLYLSAVKQIKTGHFLINPYTADGKSVQGDQLKAITRFEADLDLGYARRLVVLPVKERRQAFLTRMNEEIKHED
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: ISCS_ECOL5
Sequence: MKLPIYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGLRNRLWNGIKDIEEVYLNGDLEHGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.  Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLB_LAMFL
Sequence: MPIVDSGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVKFFTSTPAAQEFFPKFKGMTSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQVDPQYFKVLAAVIADTVAAGDAGFEKLMSMICILLRSAY
What are the official names of this protein?
Globin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: VATA_THESI
Sequence: MGRIIRVTGPLVVADGMKGAKMYEVVRVGEMGLIGEIIRLEGDKAVIQVYEETAGIRPGEPVEGTGSSLSVELGPGLLTSMYDGIQRPLDVLRQLSGDFIARGLTAPALPRDKKWHFTPKVKVGDKVVGGDILGVVPETSIIEHKILVPPWVEGEIVEIAEEGDYTVEEVIVKVKKPDGTIEELKMYHRWPVRVKRPYKQKLPPEVPLITGQRTIDTFFSQAKGGTAAIPGPFGSGKTVTQHQLAKWSDAQVVVYIGCGERGNEMTDVLEEFPKLKDPKTGKPLMERTVLIANTSNMPVAAREASIYTGITIAEYFRDQGYDVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLASKIAEFYERAGRVITLGSDERVGSVSVIGAVSPPGGDFSEPVVQNTLRVVKVFWALDADLARRRHFPAINWLRSYSLYVDAIQDWWHKNVDPEWRKMRDTAMALLQKEAELQEIVRIVGPDALPDREKAILIVTRMLREDYLQQDAFDEVDTYCPPKKQVTMMRVILNFYEKTMQAVDRGVPVDEIAKLPVREKIGRMKFEPDVEKVRALIDETNQQFEELFKKYGA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: RL24_RHIWR
Sequence: MSALKIKKGDRVVVLSGKDKGKTGEVTKSFPKDAKVIVSGVNVATRHRKPSQANPQGGLERVEAPLHVSKVAIATADGKPTRVRFEVKDGKKVRVAVKTGETING
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: EFP_XANP2
Sequence: MVKVIASSLRKGNVVDIDDKLYVVLTAENIHPGKGTPVTQLDMRRISDGVKISERYRTTEQVERAFVEDRPHTFLYEDSDGYTFMNPENFDQVIVTKDVMGDSAVYLQEGMECMLSTHNGVPIAIELPARVTLEIVDTEPTVKGQTASSSYKPAKLSNGVRTMVPPHISAGTRVVIMTADNSYVERAKD
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_POLSJ
Sequence: MQDKYNHLDVERSAQAQWIAADAYRVTEDTSGKKPRGKYYACSMLPYPSGKLHMGHVRNYTINDMLTRYLRMKGYNVLMPMGWDAFGLPAENAAMKNGVPPAQWTYDNIAYMKKQMQAMGLAIDWSREVATCDPSYYKWNQWLFLKMLEKGIAYRKTQVVNWDPVDQTVLANEQVIDGKGWRTGATVEKREIPGYYLKITDYAEELLGHVQHQLPGWPERVRLMQENWIGKSEGVRFAFTHDIRDASGALIGGGKMYVFTTRADTIMGVTFCAVAPEHPLALHAAALNPQLAAFIEECKAGGTTEAELATQEKKGKPTGLFVTHPLTGEQVEVWVGNYVLMSYGDGAVMGVPAHDERDFEFAKKYGLPIKQVTDVKGQAYSLEAWADWYGDKQQGVAINSDKYDGLGLKACVDAVAADLAAKGLGEKKTTWRLRDWGVSRQRYWGTPIPIIHCDEHGAVPVPEKDLPVVLPQDCVPDGSGNPLHRHEGFHAGVVCPVCGKPARRETDTMDTFVDSSWYYMRYCDPKNDQQMVAGGADYWMPMDQYIGGIEHAILHLLYARFWTKVMRDLGLVKIDEPFTKLLTQGMVLNHIYSRKGDKGGIEYFWPSEVEDIHDAAGKVTGAKRKSDGLLVNYEGVGTMSKSKNNGVDPQDLIERYGADTARLYTMFTAPPEATLEWNDAAVEGSYRFLRRVWNFGVKLSAAKTAAAAAQAAGFVAEYGKEAKELRREIHTVLKQIDYDYQRMQYNTVVSGNMKLLNALENFTNDGAAGSHKALHESFGILLRCLYPATPHLAHALWSELGYAAQQGDLLDAPWPEVDSGALQQDVIELVLQVNGKLRGSVTVPAGADKATIEAAALASEAFLKQAAGAPAKKVIVVPGRLVNIVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETFB_YEAST
Sequence: MSAKQQLRILVPVKRVVDFQIKPRVNKTLTGIETSGIKFSINPFDDIAVEEAIRIKEKNKSLVESTHAVSIGSAKAQDILRNCLAKGIDTCSLIDSVGKENIEPLAIAKILKAVVEKKGSNLVLMGKQAIDDDCNNTGQMLAGLLNWPQATNAAKVEFLDNGRVQVTREIDDGEEVIEASLPMVITTDLRLNTPRYVGLPKLMKAKKKPIEKLDIAKDFPEINIEPQLKIVSMEEPKTKSPGVKLNSVDELIEKLKEVKAI
What is the function of this protein?
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase.  It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
What are the official names of this protein?
Probable electron transfer flavoprotein subunit beta, Beta-ETF, Changed intracellular redox state protein 1.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: QUEG_ECOLI
Sequence: MSEPLDLNQLAQKIKQWGLELGFQQVGITDTDLSESEPKLQAWLDKQYHGEMDWMARHGMLRARPHELLPGTLRVISVRMNYLPANAAFASTLKNPKLGYVSRYALGRDYHKLLRNRLKKLGEMIQQHCVSLNFRPFVDSAPILERPLAEKAGLGWTGKHSLILNREAGSFFFLGELLVDIPLPVDQPVEEGCGKCVACMTICPTGAIVEPYTVDARRCISYLTIELEGAIPEELRPLMGNRIYGCDDCQLICPWNRYSQLTTEEDFSPRKPLHAPELIELFAWSEEKFLKVTEGSAIRRIGHLRWLRNIAVALGNAPWDETILTALESRKGEHPLLDEHIAWAIAQQIERRNACIVEVQLPKKQRLVRVIEKGLPRDA
What is the function of this protein?
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
What are the official names of this protein?
Epoxyqueuosine reductase, Queuosine biosynthesis protein QueG.
What is the protein family that this protein belongs to?
Belongs to the QueG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_CLOBB
Sequence: MDADLNKLWEKTLNIVKSEMSEVSFNTWIKSCEPISISDTSIKISVPNSFTKDILDKRYKSLVANSIEAVCSKLYEIKFIIESDLNNEDELNNSDNSDKNRDKNSRRNIVVNDEMSSTLNPKYTFNSFVIGNSNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYILQNNTKAKVVYVSSEKFTNELINAIKDDKNEEFRKKYRNVDVLLIDDIQFIAGKERTQEEFFHTFNELHDANKQIILSSDRPPKEIPTLEDRLRSRFEWGLIADIQVPDFETRMAILKKKADVENLKVANEVMGYIATKIKSNIRELEGALIRIIAYSSLTNREVTVDLASEALKDIISKKQGKHVTIPSIQEIVANYFNLKIDDLKSQRRTRNVAYPRQIAMYLSRKLTDMSLPKIGEEFGGRDHTTVIHAYEKISENLKSDESLQHTVSDITKKVSQN
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_SYNC1
Sequence: MIALLNGQLIEKTVSQVILDVGGVGYRLLIPLSTYYALPDEGDVRLRVHTHVREDALLLFGFLTETEKDLFGLLLSVSGVGPKVALNILSHLPAADLQQALSQGNAKHLATVPGIGKKTAERLVLELREKVGPVQAVPGNAPLPAETAGDLREDALSALVNLGYKENLSRKALDGIDTAPDAPLEDILKQALKLLMR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: SNF8_DICDI
Sequence: MRRGIGIQAAQKQTQTQKQLQNVSEQLNTENINKIKEQLLVFKENLEIFATKHKKDIIKNPEFRKYFQDMCNMIGVDPLASNKGFWCQVLGVGDFYYTLGVQIIEICLKYRSSNGGLMEMDTLAEHLRKLRGKNSQEISCDDIECSISKLKVLGNGFNIIKVSGGKKLVQSVPCELNKDHTDIIILAQDNNASITQSLVISKLKWSEERINNVINFLLQESMIWIDEQSNETIYWFPSLWSNFSFE
What is the function of this protein?
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.  The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity).
What are the official names of this protein?
Vacuolar-sorting protein SNF8, ESCRT-II complex subunit VPS22, Vacuolar protein-sorting-associated protein 22.
What is the protein family that this protein belongs to?
Belongs to the SNF8 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Protein: DEOD_SHEB8
Sequence: MATPHINAVEGAFAETMLFPGDPLRAKYIAETFLENVEQVTDVRNMLGFTGTYKGKRISVMGSGMGIPSCSIYATELIRDYGVKNLIRVGTCGAISTDVKVRDVIIGMGACTDSAVNRLRFKGQDFAAIANYELMNAVIESAKVRGTKVRVGNIFSADLFYTPDPQMFDVMEKMGVLGVEMEAAGLYGVAHEFGARALCVVTVSDHIRTGEKTSAEERQTTFNDMIIMTLEAAITL
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: RNH_YERPY
Sequence: MTKQVEIFTDGSCLGNPGPGGYGAILRYKQHEKTFSAGYYLTTNNRMELMAAIVALEALTSPCEVTLSTDSQYVRQGITQWIHNWKKRGWKTADRKPVRNVDLWQRLDLAIQSHTIQWEWVKGHAGHPENERCDELARQGANSPTLDDTGYNPD
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSB_ECO24
Sequence: MSGWPRIYYKLLNLPLSILVKSKSIPADPAPELGLDTSRPIMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGTLLPRYVFIHGGPRVFTYYTPKEESIKLFHDYLDLHRSNPNLDVQMVPVSVMFGRAPGREKGEVNPPLRMLNGVQKFFAVLWLGRDSFVRFSPSVSLRRMADEHGTDKTIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASRAIAKAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRLYQGINVHNAERVRQLAHDGHELVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLIPIYIGYEHVMEVGTYAKELRGATKEKESLPQMLRGLSKLRNLGQGYVNFGEPMPLMTYLNQHVPDWRESIDPIEAVRPAWLTPTVNNIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTEQLNCYLDLMRNVPYSTDSTVPSASASELIDHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLVLPSLMAAIVTQHRHISRDVLMEHVNVLYPMLKAELFLRWDRDELPDVIDALANEMQRQGLITLQDDELHINPAHSRTLQLLAAGARETLQRYAITFWLLSANPSINRGTLEKESRTVAQRLSVLHGINAPEFFDKAVFSSLVLTLRDEGYISDSGDAEPAETMKVYQLLAELITSDVRLTIESATQGEG
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y70A_METJA
Sequence: MVGNMNIRDKIKSIKNWINFIKPIITIVGIVISAVAFTISILWGMLFLILFLILITFSKTIRKILSKKERSYQGLILSIIGSIIIISIIVYSHCYIEFKLLI
What are the official names of this protein?
Uncharacterized protein MJ0703.1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ETT1_PICST
Sequence: MAKRSLGIGKASKAKKQKSAPREEEKIEKDQATEGSNEITVELNEEADANDEIAQLKALWKTYNDSEKDNELVINGIIHECDRLLRNSKLGEEKEKEKEQYTQELPDFFHSIYALALAELAKFHTEDNKKVAEYFDAAVERADLGLSQHQDSIQLLFSKSKILLHQIALQYISQLKVDTSISKKVPKLSSYLDSALRTYEEAEKKADELKKYELFNADQLEILQVLDDLLDIVDNFGKDIAEGEDDDDEVEDDEIELEESHPLYAIRESDEYNQWWRDHIILFLDNVDKHGKEIKVDFKEKAKSQEEEHPLLPLRREICKRIGQSYLQEAEVPSSVFTTLAYDDGFKNEKEINGLSLKESQKIAQKLISTALKYLQWAEDQEEPETWVNVAEAMISLGNLYEVESEEQESHYQEAEKILNKANNVTNGKYEDVLENLLGD
What is the function of this protein?
Required for correct translation termination and probably involved in regulation of hypoxic gene expression.
What are the official names of this protein?
Enhancer of translation termination 1.
What is the protein family that this protein belongs to?
Belongs to the ETT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLCN7_HUMAN
Sequence: MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT
What is the function of this protein?
Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911).  Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284).  The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity).  The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity).
What are the official names of this protein?
H(+)/Cl(-) exchange transporter 7, Chloride channel 7 alpha subunit, Chloride channel protein 7, ClC-7.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClC-7/CLCN7 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.