PharMolix/UniProtQA huggingface dataset:
Protein: MURI_ECOUT
Sequence: MATKLQDGNTPCLAATPSEPRPTVLVFDSGVGGLSVYDEIRHLLPDLHYIYAFDNVAFPYGEKSEVFIVERVVEIVTAVQERYPLALAVVACNTASTVSLPALREKFDFPVVGVVPAIKPAARLTANGIVGLLATRGTVKRSYTHELIARFANECQIEMLGSAEMVELAEAKLHGEDVSLDALKRILRPWLRMKEPPDTVVLGCTHFPLLQEELLQVLPEGTRLVDSGAAIARRTAWLLEHEAPDAKSADANIAFCMAMTPEAEQLLPVLQRYGFETLEKLAVLG
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: MINE_ACISJ
Sequence: MSLLSFLLGEKKKTASVAKERLQIILAHERSGRSAGQPDYLPALQRELVAVISKYVKINADDLKVHFERQDDLEVLEVKIELPEATAK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: DNLJ_DECAR
Sequence: MGLPEDVAKRAAWYRSELERHSYAYYVLDAPTIPDTEYDKLFRELQELEQQYPELLTADSPTHRVGGVPLKEFPPRQHGVPMLSLNNAFAPEEVEAFDKRIRDGLETIAAVDYAVEPKFDGLAISLTYENGVFTCGATRGDGVTGEEVTPNLRTLRCIPLRLRGEGWPALIEIRGEVLMFKADFAELNARQRERGDKEFANPRNAAAGSLRQLDSKITAGRPLSFFAYGVGAGADALAVKTHGEMMGLLAAWGFPVAEERRVVQGVRGLLGYFVEIGVKRPGLPYDIDGVVYKVNRLDWQAQLGFVSRAPRFAIAHKFPAEEALTEVLGIDVQVGRTGAITPVARLKPVFVGGVTVTNATLHNEDEVRRKDVRLGDTVIVRRAGDVIPEVVAIVPEKRPMRDLFGSEPLNPPFELPATCPECGSAVVKGDDEAIARCTGGLYCPAQRKQALWHFAARRAMDIEGLGDKLVDQLVDAGLVHSPADLYGLTVETLAGLERMGEKSAQNLVAAIDKSRQTTLARFIFGLGIRNVGEATARDLAKHFGGLDALLAADSAALQMVPDVGPVVAESLAAFFAEAHNREVIDGLRRAGVSWPEGEPAQAGPQLLAGKTLVLTGTLPTLKRDEAKALVEAAGGKVAGSVSKKTDYVVAGEEAGSKLEKAQELGVPVIDEAELMKLLAKGVE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PPDK2_MAIZE
Sequence: MAPAPCGRSSQRVFHFGKGKSEGNKNMKELLGGKGANLAEMASIGLSVPPGFTVSTEACQQYQEAGRALPPGLWAEVLDGLRWVEEYMGAALGDPRRPLLLSVRSGAAVSMPGMMDTVLNLGLNDQVAAGLAAKSGDRFAYDSFRRFLDMFGNVVMDIPHALFEEKLEAMKKAKGLKNDTDLTATDLKELVSQYKNVYVEAKGEPFPSDPKRQLELAVLAVFDSWESPRAKKYRSINQITGLRGTAVNVQCMVFGNMGNTSGTGVLFTRNPNTGEKKLYGEFLVNAQGEDVVAGIRTPEDLDAMKDVMPQAYKELVENCRILESHYKEMQDIEFTVQESRLWMLQCRTGKRTGKSAVKIAVDMVNEGLVERRAAIKMVEPGHLDQLLHPQFENPSAYKDQVIATGLPASPGAAVGQVVFTAEDAETWHSQGKSVILVRAETSPEDVGGMHAAAGILTERGGMTSHAAVVARGWGKCCVSGCSGIRVNDAEKVVKIGGNVLREGEWLSLNGSTGEVILGKQPLSPPALSGDLGTFMSWVDDVRKLKVLANADTPEDALAARNNGAEGIGLCRTEHMFFASDERIKAVRQMIMAPTVELRQQALDRLLPYQRSDFEGIFRAMDGLSVTIRLLDPPLHEFLPEGNVEEIVRELCSETGANQEDALARIEKLSEVNPMLGFRGCRLGISYPELTEMQARAIFEAAIAMTNQGVQVFPEIMVPLVGTPQELGHQVALIRQVANKVFTSMGKTIGYKIGTMIEIPRAALVADEIAEQAEFFSFGTNDLTQMTFGYSRDDVGKFIPIYLAQGILQHDPFEVLDQRGVGELVKLATERGRKARPNLKVGICGEHGGEPSSVAFFAKTGLDYVSCSPFRVPIARLAAAQVLV
What is the function of this protein?
Formation of phosphoenolpyruvate, which is the primary acceptor of CO(2) in C4 and some Crassulacean acid metabolism plants.
What are the official names of this protein?
Pyruvate, phosphate dikinase 2, Pyruvate, orthophosphate dikinase 2.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAAH_CORJK
Sequence: MAEEKLTFIPTADLVDIIGSDVRSCDTQFRDLGGVVEFCGKITTVKCFQDNALLKSVLQEDNPGGVLVIDGDASMHTALVGDIIAGLGKDHGWAGVVINGPIRDSKVIGQMEFGCKALGTNPRKSTKTGEGERDVTVSFGGVDFIPGEYIYCDSDGIIVSDEIVQPV
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: MMD4_DROME
Sequence: MADDEQFSLCWNNFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESLQIKGLTDNDPAPQPPQESSPPPAAPHVQQQQIPAQRVQRQQPRASARYKIETVDDGLGDEKQSTTQIVIQTTAAPQATIVQQQQPQQAAQQIQSQQLQTGTTTTATLVSTNKRSAQRSSLTPASSSAGVKRSKTSTSANVMDPLDSTTETGATTTAQLVPQQITVQTSVVSAAEAKLHQQSPQQVRQEEAEYIDLPMELPTKSEPDYSEDHGDAAGDAEGTYVEDDTYGDMRYDDSYFTENEDAGNQTAANTSGGGVTATTSKAVVKQQSQNYSESSFVDTSGDQGNTEAQAATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLNEEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCCYREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQFMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFEIQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQNKKK
What is the function of this protein?
Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators.  Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes.  Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV).  Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops.  This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery.  Within the gypsy insulator complex, this protein may control the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is unidirectional.  Isoform H is specifically required to maintain the pairing of achiasmate homologs in male meiosis I which is mediated by the rDNA repeats on the achiasmate X-Y bivalents.  Isoform H also plays a role in apoptotic regulatory pathways.
What are the official names of this protein?
Modifier of mdg4.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with other elements of the gypsy chromatin insulator complex at multiple sites on polytene chromosomes and at nuclear insulator bodies (PubMed:9491892, PubMed:11106742, PubMed:11350941, PubMed:15574329, PubMed:16209949). The unique C-termini of individual isoforms may specify binding to particular chromosomal locations (PubMed:11350941). During the G2 phase of male meiosis isoform H localizes to the nucleolus (PubMed:16286005). It subsequently localizes to the rDNA repeats of the X-Y bivalent and to multiple autosomal loci, where it remains until anaphase I (PubMed:16286005). Localization to the rDNA repeats requires SA-2, while localization to autosomal loci requires SA-2 and tef (PubMed:16286005).
Protein: NET3_CHICK
Sequence: LRLLLTTSVLRLARAANPFVAQQTPPDPCYDESGAPRRCIPEFVNAAFGKEVQASSTCGKPPTRHCDASDPRRAHPPAYLTDLNTAANMTCWRSETLHHLPHNVTLTLSLGKKFEVVYVSLQFCSPRPESTAIFKSMDYGKTWVPYQYYSSQCRKIYGKPSKATVTKQNEQEALCTDGLTDLYPLTGGLIAFSTLDGRPSAQDFDSSPVLQDWVTATDIRVVFSRPHLFRELGGREAGEEDGGAGATPYYYSVGELQVGGRCKCNGHASRCVKDKEQKLVCDCKHNTEGPECDRCKPFHYDRPWQRASAREANECLACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDLSKSITDRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAKGFQQSRSPVAPCIKIPAINPTSLVTSTEAPADCDSYCKPAKGNYKINMKKYCKKDYVVQVNILEMETVANWAKFTINILSVYKCRDERVKRGDNFLWIHLKDLSCKCPKIQISKKYLVMGISENSTDRPGLMADKNSLVIQWRDAWTRRLRKLQRREKKGKCVKP
What is the function of this protein?
Netrins control guidance of CNS commissural axons and peripheral motor axons.
What are the official names of this protein?
Netrin-3, Netrin-2.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: KIND_BACSU
Sequence: MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIAAEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPRFSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFTICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAEDQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQTQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTEQPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS
What is the function of this protein?
Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth.  Also phosphorylates spo0A under biofilm growth conditions.
What are the official names of this protein?
Sporulation kinase D, Sensor histidine kinase D.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNAK_THENN
Sequence: MAEKKEFVVGIDLGTTNSVIAWMKPDGTVEVIPNAEGSRITPSVVAFTKSGEILVGEPAKRQMILNPERTIKSIKRKMGTDYKVRIDDKEYTPQEISAFILKKLKKDAEAYLGGEIKKAVITCPAYFNDAQRQATKEAGIIAGLEVLRIINEPTAAALAYGLDKAGKEQKVLVYDLGGGTFDVSILEIGDGVIEVIATAGNNHLGGDDFDQRLIDWMAEEFKKQHGIDLREDRQALQRLRDAAEKAKIELSTKMETDVSLPFIAVSPSGQPLHLEMRITRSLFESLTRDLVEMTRGPIEQALNDAKLSPQDIDEIILVGGMTRVPMVQRFIKEFFGKEPNKSVNPDEAVAIGAAIQAAILAGTEGAKGRDIVLVDVTPLTLGIEVKGGLFEPIIPRNTKIPVRKSKIFTTVEDGQTEVEIRVYQGERPIARENIFLGSFKLVGIPPAPRGVPQIEVTFDIDSDGIVHVSAKDLGSGKEQSMVVTGRHKLSEEDIKRMIEDAKRYEEQDKRLKEEIELKNRADDLAYSVEKTLREHGDKIPADLKSKLENMIKELRDAINRNDIPRVKMLFDDLQKESMKIGEYLYKSATGGEATNQ
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: Y4216_ARATH
Sequence: MGKSARLRRSQTSSPENVLLGKDSSDDPYRSDSETESNSSSGTESNMSSDSTTSAGVSAMIRVLSDSLLRTELAEMEMIKAREAARLEAEKRRLEMEVDLTQMVLQTHLQAMSSLPVGEHKIYQAQRKRKRSDVEELESSTREKSIALLGLLQLNLIFWNSLT
What are the official names of this protein?
Uncharacterized protein At4g22160.
Protein: WHIA_LYSSC
Sequence: MSFASETKKELTQIEADNHCMKAEVSALIRMNGSLSFANKQLSLDVQTENAAIARRLYTIMKKLYPYNVELLVRKKMRLKKNNVYICRVREGARELLIDLEIISDDFQFNHTISRKLIKKNGQKRAYLRGAFLAGGSVNNPETSAYHLEIYSLYKEHGEALMDLMNEFELNAKTIERKKGFVTYLKEAEKISDFLNIVGAHQAMMKFEDVRILRDMRNSVNRIVNCETANLNKTIGAALRQVENIRFIENSIGLDQLPEKLREIARLRVEYQDVTLKELGEMVSSGTVSKSGVNHRLRKIDEIADALRRGEKIGG
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: ASP23_YEAST
Sequence: MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDAPEYAIGSGYLNPQKSRILLQLCLYSGYGMDQIRSVFSGVYGG
What are the official names of this protein?
L-asparaginase 2-3, L-asparaginase II, L-asparagine amidohydrolase II, ASP II.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family.
What are the subcellular locations of this protein?
Secreted. Periplasm.
Protein: Y4993_MYCSK
Sequence: MQPGGQPDMSALLAQAQQMQQQLMEAQESLANSEVHGQAGGGLVQVTMKGSGEVTSVAIDPKVVDPDDVETLQDLVVGAIADAAKQVTILAHDRLGPLAGGMGGLGIPGL
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Mkms_4993.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SECA_SALDC
Sequence: MLIKLLTKVFGSRNDRTLRRMRKAVSLINAMEPEMEKLSDDELKAKTNEFRARIEKGESVESLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALSGKGVHVVTVNDYLAQRDAENNRPLFEFLGMSVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKKVNKIIPHLIRQEKEDSDTFQGEGHFSVDEKARQVNLTERGLVLIEELLVQEGIMDEGESLYSPGNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTANGQPVLVGTISIEKSEVVSRELTKAGIKHNVLNAKFHANEAGIVAQAGYPAAVTIATNMAGRGTDIMLGGSWQAEVAALEAPTEEQIAQIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYTQRNELLDVSDVSDTINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLEMPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFAMFAAMLESLKYEVISTLSKVQVRMPEEVEAMEMQRREEAERLAQMQQLSHQDDDAAVAADLAAQTGERKIGRNDPCPCGSGKKYKQCHGRLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: MGN_ARATH
Sequence: MAAEEATEFYLRYYVGHKGKFGHEFLEFEFREDGKLRYANNSNYKNDTIIRKEVFLTPAVLKECKRIVSESEILKEDDNNWPEPDRVGKQELEIVLGNEHISFATSKIGSLVDCQSSNDPEGLRIFYYLVQDLKCLVFSLISLHFKIKPI
What is the function of this protein?
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  The MAGO-Y14 heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation.  The MAGO-Y14 heterodimer interacts with the EJC key regulator PYM leading to EJC disassembly in the cytoplasm (By similarity).  Can increase in vitro the expression from reporter constructs that contain leader introns required for the expression of different genes.  In association with MAGO and PYM, participates in intron-mediated enhancement of gene expression (PubMed:21676911).  The MAGO-Y14 heterodimer works synergistically with the NMD pathway to regulate male gametophyte development (PubMed:26867216).
What are the official names of this protein?
Protein mago nashi homolog, AtMAGO.
What is the protein family that this protein belongs to?
Belongs to the mago nashi family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus speckle. Nucleus. Cytoplasm, P-body. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: ARNA_ESCF3
Sequence: MKAVVFAYHDMGCLGVQALLDAGYEISAIFTHADNPAEKVFYGSVSRLAALAGIPVYAPDDINHPLWVERIAQLAPDVIFSFYYRNLLNNEILKLAPHGAFNLHGSLLPKYRGRAPLNWVLENGENETGVTLHRMVAKADAGAIIAQQRVAIDPEDAALTLHKKLCQSASQMLEYALPAIKQGQTQETAQNESEATYFGRRKPEDSFLDWNKPATVLHNMVRAVADPWPGAFSYVGTQKFTIWSSRVHPRVNAAQPGSVISVAPFLIACGDGALEVITGQSVDGITMQGSQLAQTLGLVEGSRLNSQPVCTVQRRTRVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLTHPNFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVQYHKRIIFPSTSEVYGMCTDKFFDEDHSNLIVGPINKPRWIYSVSKQLLDRVIWAYGEKEGLQFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIDGGKQKRCFTDIRDGIEALYRIIENTGNRCDGEIINIGNPDNEASIEELGKMLLASFDKHPLRQHFPPFAGFRVVESSSYYGKGYQDVEHRKPSIRNARRCLDWEPTIDMQETIDETLDFFLRTVDIVEKSS
What is the function of this protein?
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Bifunctional polymyxin resistance protein ArnA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
Protein: SIAH1_RAT
Sequence: MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11786535, PubMed:15951807).  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11786535, PubMed:15951807).  Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11786535, PubMed:15951807).  Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:11786535).  Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity).  It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription, spermatogenesis and TNF-alpha signaling (By similarity).  Has some overlapping function with SIAH2 (By similarity).  Induces apoptosis in cooperation with PEG3 (By similarity).  Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (PubMed:15951807).  GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (PubMed:15951807).  Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity).  Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1.
What are the official names of this protein?
E3 ubiquitin-protein ligase SIAH1, RING-type E3 ubiquitin transferase SIAH1, Seven in absentia homolog 1, Siah-1, Siah-1a.
What is the protein family that this protein belongs to?
Belongs to the SINA (Seven in absentia) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Protein: LEPA_BRUA4
Sequence: MSTPLDHIRNFSIVAHIDHGKSTLADRLIQLTGGLDTREMKDQVLDSMDIERERGITIKAQTVRLSYKAKNGEDYVLNLIDTPGHVDFAYEVSRSLAACEGSLLVVDASQGVEAQTLANVYQAIDNNHEIVVVLNKIDLPAAEPERVKQQIEEVIGIDAAQAVHISAKTGIGIEDVLEAIVTQLPAPKEGDRNAPLKAMLVDSWYDSYLGVIVLVRIIDGVLKKGQTIRMMGTGAKYPVERTGVFTPKMVQVDELGPGELGFITASIKEVADTRVGDTITEDRRPTNKMLSGFKPAQPVVFCGLFPVDAADFEDLRAAMGKLRLNDASFSFEMETSAALGFGFRCGFLGLLHLEIIQERLEREFNLDLITTAPSVVYRLNMQDGSQKELHNPADMPDVVKINAIEEPWIRATIMTPDDYLGAIMKLCQERRGLQIDLTYVGPRAMITYDLPLNEVVFDFYDRLKSISKGYASFDYNLSDYREGDLVKMSILVNEEPVDALSMLVHRSAAEKRGRALCEKLKELIPQHMFKIPIQAAIGGRIVARETISALRKDVTAKCYGGDVTRKRKLLEKQKEGKKRMRQFGKVEIPQEAFIQALKMGDD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYFB_DEIRA
Sequence: MKLPYSWLKELIPDLPPVADLEPTFAHLGLPLEGVEDVPAPVGGVLLVAVKAAEPMEGTQLTKLTLDTGENGEKTIASGAPNAVGLPAGTMVALVTPGTTLGGITYGVRPMQGVESWGMAASAKELGIGESNAGILTFPAGTAAPGTPLRELWPADSVLDVEVTPNRADVLSALGLARDLAAYLNLELKEPQIPAAPTQPGEIRVSLPDRGRVLDRDPQGKLRFGCDHFAARAVSGLQNGPAPLWMQRRVSLAGMRSIDLIVDTSNYVMLELGQPTALYDRRDVAGDGLVVAFGLREGETVKDLLGNTHQVGPEDLLILDAGMSDEPVMTVAEAFASAGQPKEGSHVLGIAGIMGGDHGHVRADTRDVVIESAHFDPVLLRRTSTRLGLKTDAVYRYERGVDPLLAPKAAVRVAELLRAAGGTPEAGQTVVGTPEVPQTITTTGEQIRALLGMHIGTAEMRESLTRLGCTVTGDGDSLTVTPPSWRVDMVIWQDLAEEVARLHGFTELPETLPTLRVHESNIGASAQSEARAELRRTLAGLGFQEVVTYTFTSDEEAQKARAEAPGVRLRNPMTTDRTGMRTALYPSLLRAAGAHPKGERALLFEIGRIFPAAGEQERLGLLMRGDLAARTYQDGVRGDFSVFKGLVQGFAGAVGASFALEQLRGDDVPAALHPGVAGAVVWNGERVGWLGALHPEIAQEFGLKGDTFLMEAALPLPGRDWAFRDPSRAPAAWRDLAVIAPQGVSYGDIVGVLKGAGGELLESVEPFDVFTGEQVGAGNRSVAVRLTYRGAKTLTDEEVDPVFNAQIDAVKARGWAIREK
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RB47C_ARATH
Sequence: MADVKIQSESESSDSHPVVDNQPPPPPPPPQQPAKEEENQPKTSPTPPPHWMRYPPTVIIPHQMMYAPPPFPPYHQYPNHHHLHHQSRGNKHQNAFNGENKTIWVGDLHHWMDEAYLNSSFASGDEREIVSVKVIRNKNNGLSEGYGFVEFESHDVADKVLREFNGTTMPNTDQPFRLNWASFSTGEKRLENNGPDLSIFVGDLSPDVSDNLLHETFSEKYPSVKAAKVVLDANTGRSKGYGFVRFGDENERTKAMTEMNGVKCSSRAMRIGPATPRKTNGYQQQGGYMPNGTLTRPEGDIMNTTIFVGGLDSSVTDEDLKQPFNEFGEIVSVKIPVGKGCGFVQFVNRPNAEEALEKLNGTVIGKQTVRLSWGRNPANKQPRDKYGNQWVDPYYGGQFYNGYGYMVPQPDPRMYPAAPYYPMYGGHQQQVS
What is the function of this protein?
Heterogeneous nuclear ribonucleoprotein (hnRNP)-protein binding the poly(A) tail of mRNA and probably involved in some steps of pre-mRNA maturation.
What are the official names of this protein?
Polyadenylate-binding protein RBP47C, Poly(A)-binding protein RBP47C, RNA-binding protein 47C, AtRBP47C.
What is the protein family that this protein belongs to?
Belongs to the polyadenylate-binding RBP47 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasmic granule.