PharMolix/UniProtQA huggingface dataset:
Protein: ISPE_STAAE
Sequence: MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKPPSAWVILAKPNLGISSPDIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGADGALMSGSGPTVYGLARKESQAKNIYNAVNGCCNEVYLVRLLG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
Putative 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: YL498_MIMIV
Sequence: MSLEEKLNKYSNKLSMTNNLNKIDVYNKKINKYKERQIYSNLKKPQPIDESVISLYSLKNEYQKSPDKMTALGFGVTDVGKPVELLVFDRKKPTNNEVSIEIYYTGICHSDWHFIVGEWKADFPLIPGHELIGRVIDIGPNVDKYSIGDIVCVSPVIDSCGHCKMCTHHIEQHCMNGATEIYNQKTRLPGDIKPSGPITYGGYSNIVIIKQHFVYKFPKNLDIERCAPLMCAGATTYSPLRQAKVGPGMKVGIVGIGGLGHIAVKIAKAMGAHVVAITRTEWKFKDSVNNLGANESILSTNVWQMNQHKGSFDFILSTIPMAHDIVPYIELLKYKATICTVGELFPTVINGMDLAQHPCFLQSSLIAGSDEIKEMLAFCSEHNIMPDVQIIKADKINDTRQKLLESKAKYRYVIDIRASLNK
What are the official names of this protein?
Probable zinc-type alcohol dehydrogenase-like protein L498.
What are the subcellular locations of this protein?
Host cytoplasm. Virion.
Protein: LECA_LATTI
Sequence: VTSYTLNEIVPLKDVVPEWVRIGFSATTGAEFAAHEVLSWSFHSELEETSASKQ
What are the official names of this protein?
Lectin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: RT27_YEAST
Sequence: MNVPKARLLKVAELSAKIFDQNFNPSGIRTGSKILNERLKGPSVASYYGNPDILKFRHLKTLYPDIEFVDLEEQYRLSMVEAKKRRGKGAPKKMKKDAAATAKGKGKKKK
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
Mitochondrial 37S ribosomal protein S27, Mitochondrial small ribosomal subunit protein mS33.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS33 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Protein: MTMR2_BOVIN
Sequence: MEKSSSCESLGSQPAVARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSAENFSPDLRVLRESNKLAEMEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLSLFAFEYKEVFPENGWKLYDSLSEYRRQGIPNESWRITKVNERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADRVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPRRTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGYYVRWNPRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRSTSSSERAGSPAQCVTPVQTVV
What is the function of this protein?
Phosphatase that acts on lipids with a phosphoinositol headgroup.  Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).  Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate.  Stabilizes SBF2/MTMR13 at the membranes.  Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity).
What are the official names of this protein?
Myotubularin-related protein 2, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome membrane; Peripheral membrane protein. Cytoplasm, perinuclear region. Cell projection, axon. Endosome membrane; Peripheral membrane protein. Note=Partly associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (By similarity).
Protein: RN182_RAT
Sequence: MASQPPEEPAEFQVSDELECKICYNRYNLKQRKPKVLECCHRVCAKCLYKIIDFGDSPQGVIVCPFCRFETCLPDDEVSSLPDDNNILVNLTCGSKGKKCLPENPTELLLTPKRLASLVSPSHTSSNCLVITIMEVQRESSPSLSSTPVVEFYRPASFDSVTTVSHNWTVWNCTSLLFQTSIRVLVWLLGLLYFSSLPLGIYLLVSKKVTLGVVFVSLVPSSLVILMVYGFCQCVCHEFLDCMALPS
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.  Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF182, RING finger protein 182, RING-type E3 ubiquitin transferase RNF182.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cytoplasm.
Protein: ACEA_HYPME
Sequence: MAHKKTYSQLRSELLARYPVGLTKGGVSIDDIVQLRLQSPYESHLDVARAMASVMRADMAAYDRDTGKFTQSLGCWSGFHAQQMIKAVKRLRGTTKGAYVYLSGWMVAGLRNRWGHLPDQSMHEKTSVVDLIEEIYVSLRQADEVALNDLFNELKDARAKGATNKACEEIISRIDGFESHVVPIIADIDAGFGNEHATYLLAKEMIKAGACCLQIENQVSDAKQCGHQDGKVTVPREDFIEKLRACRLAFEELGVDDGVIVARTDSLGASLTQKIPVSQQAGDFASSYIKWLKTEPITDANPLSEGELAIWQSGNFARPIRMPNGLFSFREGTGRARVIEDCIASLKDGDADLIWIETDTPNVDEIASMVAEIRKQVPDAKLVYNNSPSFNWTLNLRKQVRAQWISEGKIAEADYPDGTALMSAQYDTSELGREADDRLRQFQVDISARAGVFHNLITLPTFHLTAKSTDELSHGYFGEDRMLAYVATVQREEIRRSISAVRHQHEVGSDLGDTFKEMVSGDRALKAGGAHNTMNQFAAE
What is the function of this protein?
Involved in the metabolic adaptation in response to environmental changes.  Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.  May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway.
What are the official names of this protein?
Isocitrate lyase, ICL, Isocitrase, Isocitratase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Protein: CTIP_XENLA
Sequence: MSITASTCGSPSSSESLPNGDLFKELWSKLKECHDKDLQELLMKIGKLKKERCLDAQRLEEFYTKNQHLREQQKTLHDTIKVLEDRLRAGLCDRCTVTEEHMRKKQQEFENIRQQNLKLITELMNDKNALQDENKRLSEQLHDMQKNRHRRKSDEENPADTGDGEDGVIPDSPLSTFSLSMVSRMRRKKENKHVRYTEQTQEDALTFDRKISSGTRPQISTQVNMRKGEDVLVAETLELAPLPNKYEVCTEKPVFNLATVVAETLGLDAMEESQSQSVFNQPGITCAPLFHKSEDSSPRQVKVEFTEGSMEGFQTNDDDTEWNRREASPVFGEPVRNIRRGTDMDCSSPPLPVGLSSKLKSHCSRNAPDFSVHAKAEDGALLTRLSHCIETDSVISQCSSNRQDVLRPSPNKSDAQMGKYIFDSEQHKQTGNRYGKRKNAEAEQEESCESSFDKENNIPLKDISGARHSMLDKPLDLSDRFSVLRPQDRSHESSSRTKLTISLVPEKPDTKTILHIDLKENLHQQTRQKKVFVSGLVEHSAFNLHEDNEVTEEDNKPFHDSETEIMCHVPKRKPRAVHRGVQPTSVLQPNLHMVHACLESQGRPPIDNMQWSIDPGADLSQYEMDMTMEDSKSGSPAKPELEDMDYTYVNESCLLKLKMGDPDDSEAESKDQDSFGEMFDKTEYGEYASYIKDKSPSQSISCKERSDIPSIENKKITSEKEHESKGEPYQKQKAFVEPYFQRPERKKPAIDFPHIEVVRNKEERRKMLGHTCKECELYYADLPEEERAKKLASCSRHRFRYIPPSTPENFWEVGFPSTQTCKDRGYIKEELSPCQRPRRRQPYNAIFTSKIKEQKT
What is the function of this protein?
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway.  Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA.
What are the official names of this protein?
DNA endonuclease RBBP8, CtBP-interacting protein, CtIP.
What is the protein family that this protein belongs to?
Belongs to the COM1/SAE2/CtIP family.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with sites of DNA damage in S/G2 phase. Binds chromatin.
Protein: TTHY_BOVIN
Sequence: MASFRLFLLCLAGLVFVSEAGSVGAGEPKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTSESGELHGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEFAEVVFTANDSGPRHYTIAALLSPYSYSTTALVSSPKA
What is the function of this protein?
Thyroid hormone-binding protein.  Probably transports thyroxine from the bloodstream to the brain (By similarity).
What are the official names of this protein?
Transthyretin, Prealbumin.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family.
What are the subcellular locations of this protein?
Secreted.
Protein: METK_FRATN
Sequence: MSKNYLFTSESVSEGHPDKLADQISDAILDEILKQDKNARVACETLVKTGMALVAGEITTSAWVDIEELVRNVITETGYDNASKGIDGRTCSVINAIGKQSRDIAQGVDRGSLEDLGAGDQGLMFGFATNETPTLMPSAIYYSHLLMRKQAELRKSGKLAWLRPDAKAQVTLAYENDKPKFIDTIVLSTQHNESISQKELHDAVIEEIVKKVIPNELITKDTKYHINPTGVFLIGGPQGDCGLTGRKIIVDTYGGAAHHGGGAFSGKDPSKVDRSGAYMGRYIAKNIVAAGLADKCEVQVAYAIGVAKPVSLMVNTFGTGKITDNQIEKLVAEVFDLRVGKIIENLDLLRPIYRKTSNYGHFGRELPEFTWEKIDKADILKSAARI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COE2B_XENLA
Sequence: MFGVQETFGTALRDKALGVGMDPVRSWVRNVGVVDAKVAAQSGVAVSRAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEIERTSFVDFVENEKEFSTEKTNNGTHYKLQLLYSNGVRTEQDLYVRLIDSVTKQPISYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTDPSLEYATPCIKAISPSEGWTTGGAMVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERMAKEMLLKRAADLVEALYGTPHNNQDIILKRAADIAEALYSVPRNHNQIPALSSSPVHSGMMGINSYGGQLGVSISESQANNQGYIRNTSSISPRGYSSSSTPQQSNYSTPSNSMNGYSNVPMSNLGVPGSPGFINGSPTTSPYGIMPSSPPVGSSGSSSILPFSSSVFPSIKQKSAFAPVIRPQGSPSPACSSSNSNGFRAMTGLVVPPM
What is the function of this protein?
May play a pivotal role in the transcriptional cascade that specifies primary neurons in embryos.  Stabilizes the higher neural potential of selected progenitor cells that express neurog2/X-ngnr-1 by maintaining Delta-Notch signaling.  Thus ensures the transition between neural competence and irreversible commitment to a neural fate.  Also promotes neuronal differentiation by activating neurod1 expression, directly or indirectly.
What are the official names of this protein?
Transcription factor coe2-B, Xcoe2, Early B-cell factor 2-B, EBF-2-B, Xebf-2-B.
What is the protein family that this protein belongs to?
Belongs to the COE family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GATY_SHIDS
Sequence: MYVVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAANLHAPVIIAGTPGTFTHAGIENLLALVSAMAKQYHHLLAIHLDHHTKFDDIAQKVRSGVRSVMIDASHLPFAQNISRVKEVVDFCHRFDVSVEAELGQLGGQEDDVQVNEADALYTNPVQAREFAEATGIDSLAVAIGTAHGMYASAPALDFSRLENIRQWVNLPLVLHGASGLSTKDIQQTIKLGICKINVATELKNSFSQALKNYLTEHPEATDPRDYLQSAKSAMRDVVSKVIADCGCEGRA
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires GatZ subunit for full activity and stability.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.
Protein: TYSY_RAT
Sequence: MLVEGSELQSGAQQPRTEAPQHGELQYLRQVEHIMRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGADYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
Protein: MDTD_ECOLU
Sequence: MTDLPDNTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAIGMAVLTLALDGSKGTGLSPLAITGLVAVGVVALVLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQHVSVDSGTTQTVFMYTWLSMAFIIALPAFIFARVPNDTHQNVAISRRKRSAQ
What are the official names of this protein?
Putative multidrug resistance protein MdtD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TR2M_AGRVS
Sequence: MANFFYSRITNRSYSTKNLLNIEDKGRLKDELEKTRQTNICEICLHPRGHRASVCRQILMGFAYTSKTVLEGLLSTMPHDDAPLGKIFVTDLPPYDEQVPQVLLMQAAALVTSYEYSFEDLAYFLVLPLQMALMQKSPSLGKDFPVISGYSITKDSVHSPVAFGRNLMPRGVSCEFPQIDVLYDYRGFLEGGAFSEGVTSFPKETKKPKVAVIGAGISGLVSATLLLRNGIDDVTIFEAKNVVGGRAHTHFFKGEPSVCAELGAMRFPRSQACLFYLLEYLGINAMTKFPNPGTVDTGLYYRGRSYNWKAHSLPPAIFNRVHKGWRTFLHAGFVDGVAAFASPFTLTECLRLRNYEFASSLWQKWLDAFSSETFSSGIERIFRGAHPPGGEKWTRDVDMELFKELGVGSGGFGPVFGCGFIEILRLIVNGYEDNVMLLLDGIEEIPRRLSQQKVGSYSIRDRIIHKEVKEIIRTESGISLAIGEGMHATFDRVIVTSGFTNIQLRHLLTNDDSFFSYDVNQAIENSHMTGSSKLFVLTQNKFWKAEELPSCILTTGVAKAVYCLDYEPDKPSGKGLVLLSYTWEDDSHKLLTFDKGERFQILKRDLAKSYPRFADLLEPADGDYDNNIIQHDWILDPYAGGAFKLNRRCEDVYSKRLFFQPLRLNGEPDGRVCLAGCSCSFSGGWVEGAIQTACNAAMATIRDAGGLISGDNPLTNEFVNYHY
What are the official names of this protein?
Tryptophan 2-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2-monooxygenase family.
Protein: TNIP1_HUMAN
Sequence: MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELTGKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKMEGTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAKASGERYHVEPHPEHLCGAYPYAYPPMPAMVPHHGFEDWSQIRYPPPPMAMEHPPPLPNSRLFHLPEYTWRLPCGGVRNPNQSSQVMDPPTARPTEPESPKNDREGPQ
What is the function of this protein?
Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437).  Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription.  Increases cell surface CD4(T4) antigen expression.  Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB.  Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin.  Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases.  Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication.  May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production.  In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9. 8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.
What are the official names of this protein?
TNFAIP3-interacting protein 1, A20-binding inhibitor of NF-kappa-B activation 1, ABIN-1, HIV-1 Nef-interacting protein, Nef-associated factor 1, Naf1, Nip40-1, Virion-associated nuclear shuttling protein, VAN, hVAN.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
Protein: DUT_STUS1
Sequence: MHALQAKILDPRLGRDFPLPEYATPGSAGLDLRAMLQQDTVLEPGQTLLIPTGLAIHIADPTLAALVLPRSGLGHKHGIVLGNLVGLIDSDYQGELMVSCWNRGQSAFTIAVGERIAQLMLVPVVQARFELVDSFDSSDRGAGGFGHSGSH
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: SCG3_MOUSE
Sequence: MGFLWTGSWILVLVLNSGPIQAFPKPEGSQDKSLHNRELSAERPLNEQIAEAEADKIKKAFPSESKPSESNYSSVDNLNLLRAITEKETVEKERQSIRSPPFDNQLNVEDADSTKNRKLIDEYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIATRIYEENDRGVFDKIVSKLLNLGLITESQAHTLEDEVAEALQKLISKEANNYEETLDKPTSRTENQDGKIPEKVTPVAAVQDGFTNRENDETVSNTLTLSNGLERRTNPHREDDFEELQYFPNFYALLTSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDETIALQTKNKLEKNTTDSKSKLFPAPPEKSQEETDSTKEEAAKMEKEYGSLKDSTKDDNSNLGGKTDEATGKTEAYLEAIRKNIEWLKKHNKKGNKEDYDLSKMRDFINQQADAYVEKGILDKEEANAIKRIYSSL
What is the function of this protein?
Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:16219686).  Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (PubMed:12388744).  May also play a role in angiogenesis (PubMed:28330905).  Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity).
What are the official names of this protein?
Secretogranin-3, Secretogranin III, SgIII.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts.
Protein: EFTS_VEREI
Sequence: MAAITASMVAELRGKTDAPMMECKKALTEAGGDMAKAEELLRIKLGTKAGKAAARITAEGVVACHIDGTRGALIEVNSETDFVSKNDSFLQLARAAAELVARHQPADIAALGALAYEQDGFGPTLEDVRKGLIGKIGENMVLRRFRYFGAGHRLVSYLHGTRIGVVVEFDGDATVAKDVAMHIAAMKPVALSSAGVPAELIAAERSVAAAKAAEDKARAEAEGRPVQSDDIVAKRIEGAVHKYLKDVALFNQAFVKNDKQTVEQVLKAAGTTVKGFALYVVGEGMEKKVDDFAAEVAAQVAAAKAAVT
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSB_EDWI9
Sequence: MGKLTLLLVVLLGWLQYSLWVGKNGVHDYMRVKQDVATQQANNAKLKSRNDQLFAEIDDLNGGQEAIEERARNELGMIKPGETFYRLVPDQNKRRTVGTASQSVASYPSVTASH
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: DXR_VIBCH
Sequence: MRKLTILGATGSIGASTLKVIAQNPQQFSIVALVAGVNVAKMYQLCQQWRPKYAVMATASAASELQGLLKNQAMATEVLYGEEAMCQVAALDDVDTVMAAIVGAAGLLPTMAAVKAGKRVLLANKEALVMSGQLFIDAVAQSGAELMPVDSEHNAIFQCLPTEIQTQLGRCDLSQHGIDHILLTGSGGPFRYSDLATLDSVTPEQAIAHPNWSMGPKISVDSATMMNKGLEYIEAKWLFNTSREQLKVLIHPQSVIHSMVQYQDGSVIAQLGEPDMATPISYAMAYPERVTAGVPALDFTRLQQLTFMEVDFARYPCLQLAMDACFLGQHATTSLNAANEVAVDAFLKRKIRFTDIALINDQVLSKVCATNTQLHCRDLESLLELDTMARHFAHQVLKERQA
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: NU3M_LEMCA
Sequence: MNLPLALTTSITLTLLLVTIAFWLPQLNVYTEKYSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQTNNLKLMLTVALVLITILAAGLAYEWLQKGLEWVE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GRAS_STAA9
Sequence: MNNLKWVAYFLKSRMNWIFWILFLNLLMLGISLIDYDFPIDSLFYIVSLNLSLTMIFLILTYFKEVKLYKHFDKDKEIEEIKHKDLAETPFQRHTVDYLYRQISAHKEKVVEQQLQLNMHEQTITEFVHDIKTPVTAMKLLIDQEKNQERKQALLYEWSRINSMLDTQLYITRLESQRKDMYFDYVSLKRMVIDEIQLTRHISQVKGIGFDVDFKVDDYVYTDTKWCRMIIRQILSNALKYSENFNIEIGTELNDQHVSLYIKDYGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYLVNSVKDQLGIHLQVTSTVGKGTTVRLIFPLQNEIVERMSEVTNLSF
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).  Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX.  In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis.  Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis.
What are the official names of this protein?
Sensor protein kinase GraS, Glycopeptide resistance-associated protein S.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YHDB_BACSU
Sequence: MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAYHFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT
What are the official names of this protein?
Uncharacterized protein YhdB.