PharMolix/UniProtQA huggingface dataset:
Protein: GBA1_HUMAN
Sequence: MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
What is the function of this protein?
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose (PubMed:9201993, PubMed:24211208, PubMed:15916907, PubMed:32144204).  Plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698).  Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation (PubMed:19279011).  Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol (PubMed:24211208, PubMed:26724485, PubMed:32144204).  GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine) (PubMed:24211208).  Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide (PubMed:26724485) (Probable).  Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol (PubMed:24211208, PubMed:26724485).  Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers (PubMed:32144204).  Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside (PubMed:33361282).
What are the official names of this protein?
Lysosomal acid glucosylceramidase, Lysosomal acid GCase, Acid beta-glucosidase, Alglucerase, Beta-glucocerebrosidase, Beta-GC, Beta-glucosylceramidase 1, Cholesterol glucosyltransferase, SGTase, Cholesteryl-beta-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, Glucosylceramidase beta 1, Imiglucerase, Lysosomal cholesterol glycosyltransferase, Lysosomal galactosylceramidase, Lysosomal glycosylceramidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 30 family.
Protein: EF1A_ORYLA
Sequence: MGKEKIHINIVVIGHVDSGKSTSTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSQARFEEIQKEVSTYIKKIGYNPAAVAFVPISGWHGDNMLEASDKMSWFKGWKIERKDGNASGTTLLEALDAILPPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPPNLTTEVKSVEMHHESLPEAVPGDNVGFNIKNVSVKEIRRGYVAGDSKNDPPKAAASFNAQVIILNHPGQINQGYAPVLDCHTAHIACKFNELIEKIDRRSGKKLEDNPKFVKSGDAAIVKLIPQKPMVVEPFSNYPPLGRFAVRDMRQTVAVGVIKAVDTKEISGKTTKAAEKAQKKK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX318_LYCSI
Sequence: MKFVLLFGVFLVTLFSYSSAEMLDDFDQADEDELLSLIEKEEARAKECTPRFYDCSHDRHSCCRSELFKDVCTCFYPEGGDNEVCTCQQPKHLKYMEKAADKAKKFGGKIKKWFG
What are the official names of this protein?
U3-lycotoxin-Ls1a, Toxin-like structure LSTX-B18, Toxin-like structure LSTX-B4.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AMY3_WHEAT
Sequence: MGKHSATLCGLLVVVLCLASSLAQAQILFQGFNWESWKTQGGWYKFMQGKVEEIASTGATHVWLPPPSQSVSPEGYLPGQLYNLNSKYGSGADLKSLIQAFRGKNISCVADIVINHRCADKKDGRGVYCIFEGGTSDNRLDWGPDEICSDDTKYSNGRGHRDTGGGFDAAPDIDHLNPRVQRELSAWLNWLKTDLGFDGWRLDFAKGYSAAMAKIYVDNSKPAFVVGELYDRDRQLLANWVRGVGGPATAFDFPTKGVLQEAVQGDLGRMRGSDGKAPGMIGWMPEKTVTFIDNHDTGSTQRLWPFPSDKVMQGYAYILTHPGIPCIFYDHVFDWKLKQEITALATVRSRNGIHPGSTLDILKAEGDLYVAKIGGKVITKIGSRYNIGDNVIPSGFKIAAKGNNYCVWEKSGL
What is the function of this protein?
Important for breakdown of endosperm starch during germination.
What are the official names of this protein?
Alpha-amylase AMY3, 1,4-alpha-D-glucan glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: EIF3C_AEDAE
Sequence: MSRFFAGGGSDSDSESSSDSEVVARPAAPQFTFSDEEEDVKRVVRSTKEKRYEDLSNIIKNIRNYKKIKDMSSMLTSFEELTRAHTKALPVITKVENGVTPRFIIRALAELEDFINMVWEDKEGRKNLSKNNSKSLGTLRQKFRKYIKDFDSDLKKFRESPDAADDDEEEEEKKEESESEDEQHVAPAAAKAVSFKKEVKQVKVEKDDDESDDSIDWDMDSDSDESSSDEETQYTSIRERFLKKAEKDDGEDAENKKEKKKLQKDSKDRLKKKRAEDDDEGWEVVNGNRSTSAEQPKMFAKDAEIDVNVVINKLNEVMAARGKKRTDRKLQIEFLRELRTIADTHNLGDAVAAKIRFNIVSAIFDYNPKVSEPMKLEHWSKLLEEIQALIKLLLANDDIVLSETILEENEEYETAPYKIRGCILTAVERLDDEFTKLLKECDPHSNDYVDRLKDEVTVSSVIEQVVKYIERLGNDTETCRVYLRKIDHLYYKFDPNVLKKKKKELPASTLTSVDEMDRLCRFVYAKDQTDRLRTRAILSHIFHHALHDNWFQARDLVLMSHLQETIHHSDPPTQILYNRTMANLGLCAFRHGNVKDAHQCLVDLMMTGKPKELLAQGLVPQRQNERSLEQEKVEKQRQMPFHMHINLELLECVYLVSAMLLEIPYMAAHEFDARRRMISKTFYQQLRSSERQSLVGPPESMREHVVAAAKAMRHGNWNACSTFIVNKKMNVKVWDLFYEADRVREMLIKFIKEESLRTYLFTYSNVYASISVPYLAEMFELPKSKVHSLISKMIINEELMASLDDPTETVVLHRSEPSRLQALSMQLSDKVTNLVDSNERIFEMKQGNFFQRGGNQGYNRDRQNYRNQNQNQNWSGNRRQDNRENRGNRNQNRDRDHRKQHRVEFEEKAE
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 subunit 8.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FCRLB_MOUSE
Sequence: MWMLAALLLLVPRSGKAATLEKPVLTLHPPWTTIFKGERVTLRCDGYHPLLLELRPISTLWYLGHVLLPSHKKSIEVQAPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAAVFEGEPLVMRCRGWYDKVVYKLHYYHDGQAVRYFHSSTNYTVLQARASDSGHYQCSGTMRIPVESAPMFSSKVAVTVQELFQTPVLRTLSPQEARGRVVLRCETRLHPQKRDTPLQFAFYKYSRPVRRFDWGAEYTVPESEVEELESYWCEAATTSRSVRKRSPWLQLPGRGPVLDLASTTAPVAQAAALGPGDKPLSFRKTPVSRSVQSVTSIPNSTFAGLQFPAGHVATAGPHACAPLPASAEQSREALQPKVDLLLREMQLLKGLLSRVVLGLKDPQALHELTETPETPNSHVTVNPATPETTVMEGRVDS
What are the official names of this protein?
Fc receptor-like B, Fc receptor homolog expressed in B-cells protein 2, FREB-2, Fc receptor-like and mucin-like protein 2, Fc receptor-like protein 2, Fc receptor-related protein Y, FcRY.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Note=Seems not to be secreted.
Protein: HIR3_SCHPO
Sequence: MATFTPLNAASEDLDKEKRTLEIRIEEAVQIYQNALSAQKQGDDNAATKYYDELLNVRILRELPFTVNSNYKKNNALLLLHYLTRKNHGLFLLSKLQSLLSLDPSTDPIPVYRDALLDFAIALACDYNDIELWSFVAELAEKLEMPRIQRFALESSFYTGYEPFDAERVFTNIDDLNPGKLISLQNLYNLLKKLGGIAEPLPQLDLSISSLYTLPSFFPQLPTPSFHRRSINLCPKIKKLQLSHDTLHGFLDLVLYALQINEKKTPTRGFPSTLIIHVHSLNLSTAESHDLESTDSELWSEISDAGPDTNTINTAAKLSEPVYAKDIVPPPSDNLPKPQLLKRPIDDSDVRISKRSRGRDLRTPSESNLFSLIASITSDINEQIQKRFPDATSPFSGESMFREYSSIFEDYHQLLVNFPSEGSIPDLDVSTDSAANGAFSKMILIDLAMHSANRLEHMQVPDGYLLQLLSEVNSLNMVPAELATFFVESMLRPRKLEPPFYLQQCWGKIFKKKFTTICERIESTLHELVKASLQTPEVFNISQSLFELFLDDYFLALKFSSNDQKDDNVSEIPTESLEYKKLRCLRWKSLTEQVVELQPSCKSSSQRHLIIRNSWARNLLLRLTGCSSEAIVENFKQLRCLLQENSDSLELLNSQCMADLSVQVVDFELSKLQTVEFFNTLFMNTKNLDFNAVIKNLEPVLSPENKFAEDPQAKFISQFLEKTSTEFQIHLWYLLYQAYSSAHRPYNSLLCAFQSLKIILIRLCSSSFSIQDAGRRQAELLGMLNFSSNLFRIIWQKLHEQPDILSPCNEMTVIDCIRIILIYLRTFAIYVGIDEDISDQRIPKPSNPEFDSYAQTVKDSLMSGWCIFYTLFAHLLHYDFIKADAQKLLPQILTAIHSQYSFRGYCSSSNQSFLELSQTECQRLDAWENENEILQCVCCRFNLIIGSEYYVPQSHQSDSVNLTSNDAIKIIPFILGFAVKRSHGWVMPRSDQKNALEIICKVIRFPGENNADVYFNKCAIKEFLERDISPQLTKMLLKSNDILGLREIGSKVVDDRVRGLYYAQSQVLFGYYRSRLKGSRCINDLLVIIKYFLLDLYLNPRRQDSWYTCSSVFSSLADEELGWSAEQICLADDVINEYRRKAILCNLMALSLPFTQDKLFKANVYFDFAMNLYASARPPLEMAAFLPSETRVFSGASGLYNLSMKPIEVSKVIALAADYFGMSAELSNDWRALYMLGKACRKCGDMENALVHFEAAAALAPTKSGSGSQQALLIEPHYALLSNLSKAAIEGSVEIVQILSYLRRIRHPPKDSGSLLEVKNEDVNIYKRNALLFILKALAEMRILDKQSWHHRPTYRIAKIMEHLGNVQQAKEEMETLFSYKTSGKSLLNIWRTPNERPGRHFYYGATYSRYLLSLFYKTNDKVNFLQFLKRFRRSSSTIYEHRQIWLDIMIKYLEDLRLQHSVKETQINDLPLVEFKYVYKEISLLDEQKLSLLHQVYEIRKLNNGLYPTIKVDDFLIDCFMSLYNEVKSSISPLDANIPNSPSTITAKPLNDEKAINNENSVKQKTVITRKDVVSKVLALFRPHRETYYRETQNKILQKLASTSSSLVRSFTEDSSQAGESPGIHEEIQ
What is the function of this protein?
Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.  Required for transcriptional silencing in the outer repeat (otr) region of centromeric repeats and the Tf2 long terminal repeat retrotransposons.
What are the official names of this protein?
Histone transcription regulator 3 homolog.
What is the protein family that this protein belongs to?
Belongs to the HIR3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GATB_PSELT
Sequence: MSFKTIVGLEIHVQLMTKTKAFCSCRADVFDLPPNTAICPVCTGQPGALPTVNSTMIDYAIKIALALNCNIHEYSRFDRKNYFYPDLPKGYQITQYFYPIATSGYMDIDVDGQTKRIRIRRLHIEEDAGKLIHEGDSITQAQYSLVDMNRCGVPLVEIVTEPDLSSPKEARIFVEKLRSILRYLEVSSGDMEKGALRCDANISIYDESAHLQSNRVEVKNMNSFRFIEKALEYEQQRIIEALKNNEDVEKETRGWDIATKMTVSMRGKEEESDYRYFPEPDIPPVIVPVERIEEIKRSLVELPDEKIERFVSVYGIPKYDATVLAMNKEIADFYEACVREIDKPKEISNWIMTEMLREMKSLESENITITPAHLCELFRLMEKGEISMKIAKEVFPTVFRTGKMPGEIIKERGLKQISDENLLENIVKKVLEDNPKAVEQYKSGKTGVIGFFVGQVMKETKGAANPQVVNKIIKQILG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: Y7397_DICDI
Sequence: MAMKLLECFEFKNTYITKTPIVIVIDNDKIIPNFDRKDGSPLFFKIVNFI
What are the official names of this protein?
Putative uncharacterized protein DDB_G0287283.
Protein: CCSE1_MOUSE
Sequence: MGDSGSRRCTLVSRLPIFRKSINRRHDSLPSSPSSSNTAGVHSSSPSSTNSSSGSTGKRRSIFRAPSISFHHKKGSEPKPEPTEQNLSISNGAQPSHSNMQKLSLEEHVKTRGRHSVGFSSSRSKKITRSLTEDFEREKEPSTNKNVFINCLSSGRSEGDDSGFTEEQSRRSIKQSTKKLLPKSFSSHYKFCKSVPQSQSTSLIQQPEFSLAIAQYQEQEAALGRPSPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSLSEADAFPKSGSTASHCDNFGHNDATSQPTSSLTAVSKTKMEFVGTAPCVMSPGRYRLEGRCSTELHSSPETPAGNRREVSLQSTELSVGNGSDPETHLPAHHQRGESPLAHAGEPALRTGSPRTLGSYDQHKALAERFKGVHPVSDSRVIPSSGDHVFNKTSYGYEASAAKVLASSLSPYREGRYIERRLRSSSEGTAGSSRMVLKPKDGHVEASSLRKHRTGSSSSKMNSLDVLNHLGSCELDEDDLMLDLEFLEEQNLQPPVCREDSCHSVMSCTAVLLSPVDPGKEVNMLEEPKCPEPSKQNLSLRITKDTDQEARCSHVSCMPNSPSADWPQQGVEENGGIDSLPFRLMLQECTAVKTLLLKMKRVLQESDVSPSSSTTSLPISPLTEEPLPFKDITRDECSMLRLQLKDRDELISQLQAELEKVQHLQKAFASRVDKSTQTELLGCDGLSLKRLEAVQGGRETTHRNRTMSQSHSTRDRKAIHTPTEDRFRYSTADQTSPYKNICQLPGLCLSNFLKDKELGGVMKHTRGNHEAVTSEMTQNSRTTMGQSFLKAAAKPEGLPMFSEKPKDPAALSRQHSTFTGRFGQPPRGPISLHTYSRKNVFLHHNLHTTEFQTLGQQDG
What are the official names of this protein?
Serine-rich coiled-coil domain-containing protein 1, Coiled-coil serine-rich protein 1.
What is the protein family that this protein belongs to?
Belongs to the CCSER family.
Protein: PURA_VANPO
Sequence: MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVNGIKYDFHMLPSGLVNPNCSNLLGNGVVIHVPSLFSELNNLSEKGLKDCDKRLFISSRAHIVFDFHQHTDKLRELELKGISKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQPGAWEEFEAKYRRLLKTRRERYGDFEYDPEEELNRYKKYKELLKPMVVDSVFFINNAIANGKKILVEGANALMLDIDFGTYPFVTSSSTGIGGVITGLGVSPRHINEVYGVVKAYTTRVGEGPFPTEQLNEQGEKLQTIGAEFGVTTGRKRRCGWLDLVVLKYSAMINGYTSLNITKLDVLDTFKEIPVGVSYSINGKKLDSFPEDLINLGNVDVEYVTLPGWDQDITKITEFDQLPENAKKYLKFIEDFVGIPIEWVGTGPARESMLHRDV
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBD6_MOUSE
Sequence: MNGDNASSAADRAGGPAATPVPIPIGWQRCVREGAVYYISPSGTELSSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPPSVRPPCRAPPTTPLNGGPGSIPQDPPSVPQAFPPLTGPAGLFPPPRLPDPVPSAGSSSPCFLPRGNAPSPAPPPPPAISLNAPSYNWGASLRSNLVPSDLGSPPAPHASSSPPSDSPLFHCSDALTSPPLPPSNNPPGPPGPPGPATQPPVSSATMHLPLVLGSLGGAPAVEGPGAPPFLASSLLSAAAKAQLPPPSTLQGRRPRAQAPSAAHASPRPSQRRPRRPPTVLRLLEGGGPQTPRRTRPRAPAPVPQPFPLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPALSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSDGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPFLSHSLFGVLAGGGQPPPEPLLPPPGGPGPPSAPGEPEGPSLLVASLLSPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPNGEPFSGLGDLPPLLFPPLSAPPTLIALNSALLAASLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPQLLSPLLSASLLGDLSSLASSPGALPSLLQPPGPLLSSQLGLQLLPGGGAPPALSEASSPLACLLQSLQIPPEQPDAPCLPPESPASALEPEPARPPLSALAPPHASPDPPVPELLTGRGSGKRGRRGGGGLRGINGETRPGRGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPLPGTHSEDLKVPPGIVRKSRRGRRRKYNPARNSSSSRQDVTLEPSPTTRAAVPLPPRARPGRPAKNKRRKLAP
What is the function of this protein?
Binds to heterochromatin.  Does not interact with either methylated or unmethylated DNA (in vitro) (By similarity).
What are the official names of this protein?
Methyl-CpG-binding domain protein 6, Methyl-CpG-binding protein MBD6.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with pericentric heterochromatin in about 25% of the cells.
Protein: MPTA_METS3
Sequence: MAVCLPDTQDDTPSIPIKLTRVGVTGVKKLLQLERNNKRPIILVPTFDAFVDLPNDQKGVHMSRNPEAISEVLDEVANDSSVEVETLCAKIVSKMMSKHEYAKRVEISMTTDYMFMKESPVTKNKTQEMAKLKAKAVGYREDGEIKIRKSIGAEVIGMTVCPCAQESVKESDKNKLLEFLDEETTQKVLDTVTFASHNQRGVGTLLIEVPEDREVKGEDIIEIIEESMSSPVCELLKRPDENATVLNAHKKPVFVEDCVRNMMEKIAKKYADFPEDTIITSRQENHESIHRHNAFAEKVTTMGELKEELRI
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: HEMH_TRIEI
Sequence: MSRVGILLLNLGGPEQLEDVRPFLFNLFSDPEIIRLPFPWLQKPLAWFISTMRFQKSQENYKEIGGGSPLRSITEEQALAIQQQLEQKGLLTQMYIGMRYWHPFTEEALTRIKREQVEKLVILPLYPQYSISTSGSSFRLLDKLWEKDSELKKIEYTVIPSWHQRPGYVQAMVELITQQLDQSPNPDQVHIFFSAHGVPVSYVEEAGDPYQAEIEECVDKIMKTLNCSNPHTLAYQSRVGPVEWLKPYTEDAIEELAAGGVKDLLVVPISFVSEHIETLQEIDIEYRELAEEAGISNFYRVPALNTHPVFINDLADLVMEALDAPSRDFSDAIQMKKIIKMYPQERWQWGLTTTAEVWNGRLAMVGFMALLLELITGYGPLHFAGLL
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENDO5_ARATH
Sequence: MRLWIVSVLVLTHLVHGALCWGKDGHYTVCKLAEGFFEDDTIAAVKKLLPESVDGGGLADFCSWPDEIKKLSQWQWTSTLHYVNTPEYRCNYEYCRDCHDTHKHKDWCVTGAIFNYTNQLMSASENSQNIVHYNLTEALLFLSHYMGDVHQPLHTGFLGDLGGNTIIVNWYHNKSNLHHVWDNMIIDSALETYYNSSLPHMIQALQAKLKNGWSNDVPSWKSCHFHQKACPNLYASESIDLACKYAYRNATPGTTLGDEYFLSRLPVVEKRLAQGGIRLAATLNRIFSAKPKLAGL
What is the function of this protein?
Hydrolyzes, with low efficiency, only single-stranded DNA and RNA without apparent specificity for bases (PubMed:17651368, PubMed:23620482).  Endonuclease that recognizes and cleaves some mismatches with high efficiency, including heteroduplex double-stranded DNA; mostly efficient on T/G, A/G and G/G mismatches, less efficient for T/T and poorly efficient for C/C, A/A, T/C and A/C (PubMed:17651368).
What are the official names of this protein?
Endonuclease 5, AtENDO5, Deoxyribonuclease ENDO5, Single-stranded-nucleate endonuclease ENDO5.
What is the protein family that this protein belongs to?
Belongs to the nuclease type I family.
Protein: KXD1_YEASO
Sequence: MVTGISEENDDEETFSAVHSSTPSINSQSYAIPITEEMSSSFHDSISTTSNSSGSFDSDGSNVSDVVEQNEMDNESNVDEDLFLDNDIPQSSNLLPTDAQDPGPIFDVSRYIFDSLKQSIDSADFSEALSLQTKTSAVINSKSLELKQYIDEMKSRLTQLQEKFENGEATSKKIKRDLETSRKNIDYLNAALRVDFPIEFNQAREKILERRLNEDHDC
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit KXD1, BLOC-1 subunit KXD1, KxDL homolog.
What is the protein family that this protein belongs to?
Belongs to the KXD1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: NDOA_PSEAI
Sequence: MTEKWIDAVALYEIPEGDVLGVTVEGKELALYEVEGEIYATDNLCTHGAARMSDGFLEGREIECPLHQGRFDVCTGRALCAPVTQNIKTYPVKIEGQRVMIDLS
What is the function of this protein?
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene.  Functions as an intermediate electron transfer protein via a specific interaction with iron sulfur protein components (ISP) (NdoB and NdoC).
What are the official names of this protein?
Naphthalene 1,2-dioxygenase system, ferredoxin component.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin component family.
Protein: PURA_RHOPT
Sequence: MANVVVVGAQWGDEGKGKIVDWLSEQADIVVRFQGGHNAGHTLVINGQTYKLALLPSGVLRPSKLAVIGNGVVFDPQAFLDEVKKLQGQGVAISPENLRIAENVTLILPLHRELDATRENAAKAGAIGTTQRGIGPAYEDKVGRRAIRLMDLADLDTLPTKIERLLAHHNALRRGLGQPEIDAGQILADLSAMAPHLLPYAESVWRLLDIKRREGKRILFEGAQGALLDVDHGTYPYVTSSNTVAAQAATGTGMGPGAVGYVLGICKAYTTRVGAGPFPTELTNEIGEEIGRRGKEFGVNTGRKRRCGWFDAVLVRQTVRTCGIHGLALTKLDILDGFDSVEVCVGYKLDGKEIDYLPAGEGAQARVEPIYETIEGWKEPTANARSWAELPAQAIKYVRRIEELVGCPVALLSTSPEREDTILVQNPFEA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG107_MONPV
Sequence: MDKTTLSVNACNLEYVREKAIVGVQAAKTSTLIFFVIILAISALLLWFQTSDNPVFNELTRYMRIKNTVNDWKSLTDSKTKLESDRGRLLAAGKDDIFEFKCVDFGAYFIAMRLDKKTYLPQAIRRGTGDAWMVKKAAKVDPSAQQFCQYLIKHKSNNVITCGNEMLNELGYSGYFMSPHWCSDLSNME
What is the function of this protein?
Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry.  Also plays a role in cell-cell fusion (syncytium formation).
What are the official names of this protein?
MPXVgp092.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG107 family.
Protein: NDHJ_PROM2
Sequence: MEKEGLAKSSDTSIKKEGFISQSLSKDGIPNQSLPDDHIGIENISVEPNKLYEAVSNLRNYGFNYLQCQGGYDEGPGKNLVSFYHFITVDDFQKIEKIKEVRLKVFLKRDSDLSIPSLYKIFKGSDWQERETYDMYGINFIDHPNPTRLLMPEDWRGWPLRKDYIQPDFYELQDAY
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J, NDH-1 subunit J, NDH-J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VATB_THEGJ
Sequence: MPGMEYSTVSKIYGPLMIVEGVKGVAYGEVVEIETESGEKRKGQVLEARENLAIVQVFEGTRDLDIKTTRVRFTGETLKVPVSMDMLGRIFNGIGKPIDGGPEIIPEDRRDVHGAPLNPVARAYPRDFIQTGISAIDGMNTLVRGQKLPIFSGSGLPHNMLAAQIARQAKVLGEEEQFAVVFAAMGITYEEANFFKKSFEETGAIERAVLFLNLADDPAIERIITPRMALTVAEYLAFDYDMQVLVILTDMTNYAEALREISAAREEVPGRRGYPGYMYTDLATIYERAGRVRGKKGSITQMPILTMPDDDITHPIPDLTGYITEGQIVLSRELHRKGIYPPIDVLPSLSRLMKDGIGKGRTREDHPQLSQQLYAAYAEGRSLRDLVAVVGEEALSETDRKYLKFADRFEREFVAQRYDEDRSIFETLDLGWELLAELPESELKRVRKEYILKYHPKYRKRGS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: COX3_FELCA
Sequence: MTHQTHAYHMVNPSPWPLTGALSALLMTSGLAMWFHYNLTLLLTLGMTTNLLTMYQWWRDIIRESTFQGHHTPIVQKGLRYGMILFIISEVFFFAGFFWAFYHSSLAPTPELGGCWPPTGIIPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRKHMLQALFITISLGVYFTLLQASEYYETSFTISDGVYGSTFFMATGFHGLHVIIGSTFLIVCFLRQLKYHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.