PharMolix/UniProtQA huggingface dataset:
Protein: EXO84_SCHPO
Sequence: MPDNPSSFEDEFMKSNHLSVASESIPNESQRQSPTRLRVGTSKTDDIYRQKRQTKHIISQNEVFLQPKFFDNQNFDAQSYLNDVLQDLSEDEFVSLYNKLLRIHMGVRKNLEKNFYKNLNEYVFISGEVESMTSDFKKFQSLLKTLETDIEGLNLVDHTHDPSDESIKQTVQRLRSSIEGLDEAFWEAPQRQLICEQYNWMLINIDNQRPKLLVNMLLFNDRLLVTTSHMKEVDFPAKQQVLYNWNLTEISISSIETYGPAGAEMLQKEKEVSLYKLSINHNNKTTLLAVHNSEERDYMVRQARHHQLQELENWSRKHDEDLEFSRELEYHTKSEQADMCSYTSFQVLCKNLDTQDILQAYAKQRNMVKEISMQFDHLDIQISLQEFTDAIRNLALIQNKLERGNLNELFAEFFADKLHNRKRKVTEILLHQLGFKGISLSHGKEIVRYLRSLGHEKEGQGVFMKSRTLLIKEKCLNVQLEKDTPNFIDACAFIVFRCLAQTTSSYLQLFELKKLDPAYRNWIFQQIEALVDLIENQYKHLAHDRSYTDAVSKIMTYNTELKEAKIDAMPILQRLFDVHSKDLK
What is the function of this protein?
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis.  Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis.  Also involved in assembly of the spliceosome (By similarity).
What are the official names of this protein?
Exocyst complex component exo84.
What is the protein family that this protein belongs to?
Belongs to the EXO84 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Note=Cell periphery. The polarization of EXO84 requires actin cables (By similarity).
Protein: NSP3_ROTHD
Sequence: MLKMESTQQMASSIINSSFEAAVVAATSTLELMGIQYDYNEVYTRVKSKFDFVMDDSGVKNNLMGKAATIDQALNGKFSSSIRNRNWMTDSKTVSRLDEDVNKLRLLLSSKGIDQKMRVLNACFSVKRVPGKSSSVIKCTRLMKEKIERGEVEVDDTFVEERMEIDTIDWKSRYDQLERRFESLKQRVNEKYNNWVIKARKVNENMNSLQNVISQQQAHINELQIYNNKLERDLQSKIGSVISSIEWYLRSMELSDDIKSDIEQQLNSIDHINPVNAFDDFESILRNLISDYDRIFIMFKGLLQQSNYTYTYE
What is the function of this protein?
Plays an important role in stimulating the translation of viral mRNAs.  These mRNAs are capped but not polyadenylated, instead terminating in a conserved sequence 'GACC' at the 3' that is recognized by NSP3, which competes with host PABPC1 for EIF4G1 binding.  The interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1 interaction, thereby facilitating the initiation of capped mRNA translation.
What are the official names of this protein?
Non-structural protein 3, NSP3, NCVP4, Non-structural RNA-binding protein 34, NS34.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP3 family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: RUVA_BRUA4
Sequence: MIGKLKGVIDEIAEDHAVIDVHGVGYVAFCSARTLGNLGGVGEAAILFIETYVREDMIRLYGFANQLEREWFRLLQNVQGVGAKVALAVLGTLSPSELANAIALRDIAMVSRAPGVGKKVAERIVTELKNKAPAFAGDASGTIGLKQELGAGAAPAPVADAVSALSNLGYSRDQAANAVAAALKEAGENADSAKLIRLGLKELSR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: SCPF_ARTBC
Sequence: MKGLLSLLLVGAANALAASYEPRSLTEDMLQGKEKEVWDAIKGEIPGAQLDDYFNPPTAHQREPDEKWDGKLEGKSVNTLWVEEGKDKPSGIEEYGMRFKTVDPSSLGVDNVTQYSGYLDNKKNGQHLFFWFFESRRDPQYDPVILWLNGGPGCSSMTSLFMELGPARVGQDLKLTRNPNSWNNRASIIFLDQPVNVGFSYGKSGAFNTPSASKDVFAFLTLFFKKFPQYALQDFHIAGESYAGHYIPFASYPPMACGKGGYSAVLDQPTCKAMEAAVPQCQKEIKRCYDKPTDVATCVKGAKFCKDALVRPYSRTGQSIYDIRGRCEDPKDLCYPILGWIAKYLNQRHVQKAIGAEVSHFKGCSNHISSQFFAHGDYNQPFHRKIPGILKDVNVLVYAGDADYICNWLGVKEWTEALQWPGRHIFRRKNLSVVYHSVNKWPLGRVKYHNGLAFLQVFKAGHRVPYDQPENALDFFNRWLAGEWTP
What is the function of this protein?
Involved in degradation of small peptides.
What are the official names of this protein?
Carboxypeptidase Y homolog ARB_07161, Serine carboxypeptidase ARB_07161.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS14_BRUA4
Sequence: MAKTSAVEKNKRREKLVKRHADKRARLKAIVMDQGLPLEERFRATIRLAELPRNSSKVRIRNRCEVSGRPRGYYRKLKMSRIALRQLGSLGQIPGIVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RS8_CHLCH
Sequence: MPVTDSIADYITRIRNAGRAKNSTTDIPYSKLKENISQLLLEKGYIKNFTVITTEKFPFLRIDLKYMQSGEPAIKELTRVSKPGRRVYDGKDIKKYLGGLGLYVLSSSKGVITDKEARAQGVGGEILFRIY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: HBSAG_HBVC9
Sequence: MGGWSSKHRKGMGTNLSVPNPLGFFPDHQLDPAFGANSNNPDWDFNPNKDHWPEANQVGAGAFGPGFTPPHGGFLGWSPQAQGILTTVPAAPPPASTNRQSGRQPTPISPPLRDTHPQAMQWNSTAFHQALQDPRVRGLYFPAGGSSSGTVNPVPNTVSHISSIFTKTGDPASNMESTTSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGAPGCIGQNSQSQTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLLPGSTTTSTGPCRTCTITAQGTSMFPSCCCTKPSDGNCTCIPIPSSWGFAKFLWEWASVRFSWLSLLVPFVQWFAGLSPTVWLSVIWMIWYWGPSLYNILSPFLPLLPIFLCLWVYI
What is the function of this protein?
The middle envelope protein plays an important role in the budding of the virion.  It is involved in the induction of budding in a nucleocapsid independent way.  In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
What are the official names of this protein?
Large envelope protein, L glycoprotein, L-HBsAg, LHB, Large S protein, Large surface protein, Major surface antigen.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus major surface antigen family.
What are the subcellular locations of this protein?
Virion membrane.
Protein: RDGC_ECOSE
Sequence: MLWFKNLMVYRLSREISLRAEEMEKQLASMAFTPCGSQDMAKMGWVPPMGSHSDALTHVANGQIVICARKEEKILPSPVIKQALEAKIAKLEAEQARKLKKTEKDSLKDEVLHSLLPRAFSRFSQTMMWIDTVNGLIMVDCASAKKAEDTLALLRKSLGSLPVVPLSMENPIELTLTEWVRSGSAAQGFQLLDEAELKSLLEDGGVIRAKKQDLTSEEITNHIEAGKVVTKLALDWQQRIQFVMCDDGSLKRLKFCDELRDQNEDIDREDFAQRFDADFILMTGELAALIQNLIEGLGGEAQR
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: KEA1_ARATH
Sequence: MEYASTFQRPILFHGGDGASYCFPNRLISPKGISITSGDSKVHSCFRLRRNVAQSGTLNLMNACFSGRFYSGHLHSTKSILGNGHQAKRIPFGFRLRCQGHESLGNADSNDHRIGESSESSDETEATDLKDARVENDTDSLEELKELLHKAIKELEVARLNSTMFEEKAQRISERAIALKDEAATAWLDVNKTLDVIRDTVYEEALAKEAVQTATMALSLAEARLQVIVESLEAGAGNDIPHVSEETEETIDVNDKEEALLAAKDDIKECQVNLDNCESQLSALLSKKDELQKEVDKLNEFAETIQISSLKAEEDVTNIMKLAEQAVAFELEATQRVNDAEIALQRAEKSLSISQTPEETQGQLSDEETSQEDAMVLSGNVEDVTHQVEKESPKDGDLPVVQITAELVPDIVGQRNKKLTQPYESSDHENGKPSVESSKVVEADSEKPKINVQTKKQETQKDLPKEGSSLNSPKASFNKSSRFFSASFFSSNPDGTATVFGSLVGSVKQQWPKLVLGLALLGAGLTLYSNGVGGNNQLLQQPDVTSTSTEDVSSSTKPLIRQVQKLPKRIKKLLEMIPHQEVNEEEASLFDFLWLLLASVIFVPLFQKIPGGSPVLGYLAAGILIGPYGLSIIRNVHGTRAIAEFGVVFLLFNIGLELSVERLSSMKKYVFGLGSAQVLVTAAVVGLLAHYVAGQAGPAAIVIGNGLALSSTAVVLQVLQERGESTSRHGRASFSVLLFQDLAVVVLLILIPLISPNSSKGGIGFQAIAEALGLAAVKAAVAITAIIAGGRLLLRPIYKQIAENRNAEIFSANTLLVILGTSLLTARAGLSMALGAFLAGLLLAETEFSLQVESDIAPYRGLLLGLFFMTVGMSIDPKLLLSNFPVIVGTLGLLIVGKTMLVVIMGKLFGISIISAIRVGLLLAPGGEFAFVAFGEAVNQGIMSPQLSSLLFLVVGISMAITPWLAAGGQLIASRFELHDVRSLLPVESETDDLQGHIIICGFGRVGQIIAQLLSERLIPFVALDVSSDRVTIGRSLDLPVYFGDAGSKEVLHKIGAGRACAAVVALDAPGANYRCVWALSKFYPNVKTFVRAHDVVHGLNLEKAGATAVVPETLEPSLQLAAAVLAQAKLPTSEIANTINEFRTRHLSELTELCEASGSSLGYGYSRTSKPKPQPSDASGDNQIIEGGTVVI
What is the function of this protein?
Electroneutral K(+)/H(+) efflux antiporter involved in chloroplastic K(+) homeostasis and osmotic adjustment, especially during plastid division and thylakoid membrane formation (PubMed:24278440, PubMed:33111995, PubMed:27443603, PubMed:31296940).  Collaboratively with KEA2, adjusts alkaline stromal pH upon light to dark transitions in plastids (PubMed:33111995).  Together with KEA2, critical for chloroplast development, including chloroplast RNA-metabolism (e. g.  rRNA maturation, polysome loading and RNA-protein interactions) and plastid gene expression (PGE), ion homeostasis, and photosynthesis (PubMed:34235544, PubMed:27443603).  Contributes, during early seedling development, to the regulation of photosynthesis and abscisic acid- (ABA-) mediated primary root growth in a sucrose-dependent manner (PubMed:35193734).  Involved in the regulation of reactive oxygen and nitrogen species (ROS and RNS) metabolism (PubMed:33485149).  Required in roots for rapid hyperosmotic-induced Ca(2+) responses and for osmo-sensory potentiation in hyperosmotic conditions (PubMed:27528686).  May counteract resilience to drought and salt stress, involving photorespiratory pathway and stomata closure (PubMed:33485149, PubMed:34235544).
What are the official names of this protein?
K(+) efflux antiporter 1, chloroplastic, AtKEA1.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KEA (TC 2.A.37.1) subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: CF299_BOVIN
Sequence: MDQDEALTTVDNIVTQFNTYEDFLDSQITTLDLYYLEDEGLARQLVELGYRGTGEVVKREDFEARKAAIEIARLAERTQKKTLTSAGKDLHDNFLKALAVREEDNRSGKSVIFIRDKNSHGQEVSGYIDYAHRLKTEDFEVYFSGKKRLLPRPTDMSFYNWDSHIAIWNSTPNYQVIADNPEGLLFKYKRDRKILNVDPKAQPGDNSTRSPILTELYTQVVIFDHVSRRKT
What is the function of this protein?
May be involved in spermatogenesis.
What are the official names of this protein?
Cilia- and flagella-associated protein 299.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly cytoplasmic.
Protein: FER1_HYONI
Sequence: ATYKVKLVTPDGPVEFNCPDDVYILDQAEEEGHELPYSCRAGSCSSCAGKVSAGTVDQSDGNFLDDDQIADGFVLTCVAYPQSDVTIETHKEEDLTG
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin-1, Major ferredoxin.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PBX4_MOUSE
Sequence: MAAPLRPVPPQPAPRRLPTTAPLGHDTSDVLQQIMAITDQSLDEAQARKHALNCHRMKSALFSVLCEIKGKTAVSIQFQEEDPPDAQLLRLDNMLLAEGVSRPEKRGRGAAAGSTATPGGCPNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLREQSRVRPVSCREMEHMVNTIQSKFSAIQRQLKQSTCEAVMTLRSRFLDARRKRRNFSKQATDVLNEYFYSHLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKNTGKFQEEATMYTGKASTVTKARRPRGQSSCQSTPSPGPCGPLPLTNGSDVVLTLRTLAFLQPPTGGVCLQPLVHSNWQRAAPQPASSPAGESGSFNWDAASN
What are the official names of this protein?
Pre-B-cell leukemia transcription factor 4, Homeobox protein PBX4.
What is the protein family that this protein belongs to?
Belongs to the TALE/PBX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IBP7_MOUSE
Sequence: MERPPRALLLGAAGLLLLLLPLSSSSSSDACGPCVPASCPALPRLGCPLGETRDACGCCPVCARGEGEPCGGGAAGRGHCAPGMECVKSRKRRKGKAGAAAGGPATLAVCVCKSRYPVCGSNGITYPSGCQLRAASLRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAKVFLSCEVIGIPTPVLIWNKVKRDHSGVQRTELLPGDRENLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASAAAKITVVDALHEIPLKKGEGAQL
What is the function of this protein?
Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production.  Stimulates cell adhesion (By similarity).
What are the official names of this protein?
Insulin-like growth factor-binding protein 7, IBP-7, IGF-binding protein 7, IGFBP-7, MAC25 protein.
What are the subcellular locations of this protein?
Secreted.
Protein: RBSK_DICDI
Sequence: MENNITVVGASNWDTFIYVDKMPRVGETIKGTDLKVSYGGKAANQAVQASLLGSNCTLITKLGDDPSGVNTLKNFKDKNINCEFVSVVSNVPSGCATIIVDKNGDNNIIIIGGSNDLLNEKDVDNAKSQIQNSSLLLCQLEVSLNVTLHALKIAKESNKCKTMLNLTPINNDPLILEMFKFVDILIVNEIELIGLYNSTFNNNNNNEKDFNINQLMEMCDNLIKKFENFENIIVTLGGNGQLLVSKENNKNCHIELKEKVKVVDTSGAGDSFIGSFAHYLVTENKPLKDSIESASKVASISVTRHGTQTSYPKSNEIN
What is the function of this protein?
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium.  The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
What are the official names of this protein?
Ribokinase, RK.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRPA1_CAEEL
Sequence: MSKKSLGLDVRLELEGLISNDDTIRSEKDGRQASIFRVAELDARTEADNLRSIIHQSAREGNVNALQEALLKAPLAVNAQDGDFMTPLHYAARYGNYDAVKLLLSKNALPNTKNREGDTPLHIASKYIYGYSDICSIIDEDQADSARKYNTATKKIINALVSENAEIDPVNKYQLTPLHYAAMKSNFSALHALIKLKADVDAEDDNKMTPLLLACVHGSQEIIQELIKANSNVTKRDQRLNTVFHIVALRGEPEYLEMMMDHDPVEAIKALNLFNNEKKTPLRMAVEGNHPETLKKILQMEKKNSCKWMDREKELIHFAAEKGFLEVLKALVEAGGNKNELNEVKAVPLHVAAQMNQLEVVSYLIEEEKDNIDVVDEQGLTPLMMAVTHDSKKCVEYLIAKKANLTITDKDERTPVFIGAKFNALSSVEYILDHLRKKNKETERSALKSPTRNTLRIVSEDVRRTMVNMVDRDQNTPMHIVASNGYLEMMQLLQKHGASITQVNEDEETALHRAAIGGQTGAVRQLLEWDIRLLLMKDEMGNSALHLAARSGHDATTKVLLDNGADKEAKNSYQKTPLQVAVDSGKLETCQRLVAKGAQIESSSDTKTVLHTAAFYGNESIVRYFIAEGVTIDRRDEEGKTAFDIACENDHKDVARAFLETDQWKNLMIPCDVIPLDKHRNPVNMKRRTPFRTLLTKFPELASFVMDNCIEKSKEETDSTQSVAYNFEFLDDTYMMRCVSDDGTGEQLIGCKSAYDEDFKLEKDAQSYASNYDRVYKYHPLKLMADAEKLHLLNHPLSKALLKYKWNRLGRPMYYFALFMYLVFIVSLTQYVRHTKAPYNVWNEESYYDSEYFDENETCPQINTTKPDVVWKIIIQTLAVCQILVECFQLFQRKFAYLVNWENWIDCFIYSTALITVYDFSECSATSGVRQNWQWILAALCIFFGWINLLFMIRKMPRFGIFVVMFVDIVKTFFRFFPVFVLFIIAFSSSFYVILQNRPEFSTIFMSPLKTTVMMIGEFEFTGIFHGDETTHAEKMFGPAHTAVACALFFFFCIIMTILLMNLLVGLAVDDIKGVQEKAELKRLAMQVDLVLQIEASLHFFIQRTKKYATCRYATFPYGKLHKTGFAGWWSNFRRRFGLSVSTDPEIDEMYEREAEFTSEMTQKLQNQAAKLKNIQENIDVMYEKQVRLEAIIAKLATGLNINIELEEKDN
What is the function of this protein?
Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior.  Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation.  Has no apparent role in thermosensory or chemosensory behaviors.
What are the official names of this protein?
Transient receptor potential cation channel subfamily A member 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DSA2B_TORMA
Sequence: MEYRTDQVPMSPRSVQGAPGTLPIRDHLPWSIFNLFYMNVCCLGLTAMIFSVKSRDRKVVGDVEGARHYGSTARSLNIAATVLGILLIIILIGLAATGTIQALKYKG
What are the official names of this protein?
Dispanin subfamily A member 2b, DSPA2b, 14 kDa transmembrane protein.
What is the protein family that this protein belongs to?
Belongs to the CD225/Dispanin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RUVA_BACAC
Sequence: MFEYVTGYVEYVGPEYVVIDHNGIGYQIFTPNPYVFQRSKQEIRVYTYHYVREDIMALYGFKTREERLLFTKLLGVSGIGPKGALAILASGQTGQVVQAIEHEDEKFLVKFPGVGKKTARQMILDLKGKLADVVPDAFVDLFSDEERFDEKKGSSAELDEALEALRALGYAEREVSRVVPELLKESLTTDQYIKKALSLLLNGKR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: SECA_CAMJ8
Sequence: MFLNTLKAVFGTKNDREVKKYFKRVAQINALEGKYQNLSDDELKAEFAKFKEQILSGEKNENDILNDVFAIVRETGKRTLNMRHFDVQLIGGMVLHDGKIAEMKTGEGKTLVATLPVVLNAMSGKGVHVVTVNDYLAKRDAEQMSAIYNFLGFSVGVILSSQNSDIEHKQAYDCDITYGTNNEFGFDYLRDNMKFSKVEKVQREHNFVIVDEVDSILIDEARTPLIISGPTNRTLDGYIKANEVAKQMQKGEAVLPPAKPEGDFVVDEKNRNILITEAGIAKAEKLFGVENLYSLDNAILAHQLDQALKAHNLFEKDVHYVLRNNEVIIVDEFTGRLSEGRRFSEGLHQALEAKENVKIQEESQTLADITFQNYFRMYNKLAGMTGTAQTEATEFSQIYSLDVISIPTNIPIKRQDKDDLIYKTQNEKFKAVIEEIKKANSKGQPVLVGTASIERSEVFHNMLVKEKIPHHVLNAKNHEQEALIIQDAGKKGAVTIATNMAGRGVDIKIDDEIRALGGLYIIGTERHESRRIDNQLRGRAGRQGDPGISRFYLSLEDNLLRIFGGDRIKNIMDRLGIEEGESIESRIVTRAVENAQKKVESLHFESRKHLLEYDDVANEQRKTIYRYRNELLDENYDIRAKISQNIAEYSANVMNDYILDESGSNVNFENLKAKILYECSTQISEKDFENLSVIEMQDKLSQILENSYNEKMSRLGIKELRNIERILYLQVLDNAWREHLYQMDILKTGIGLRGYNQKDPLVEYKKESYNLFLELVNRIKFDSIKLLFSVQFNQEEVQNLENKANEENEKLLQSSVEMGASEDNLGEAEFKKVPRNAPCPCGSGKKFKECHGKSGPKQGILA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: HSP7D_MANSE
Sequence: MAKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTDRLIGDAAKNQVAMNPNNTIFDAKRLIGRKFEDATVQADMKHWPFEVVSDGGKPKIKVAYKGEDKTFFPEEVSSMVLTKMKETAEAYLGKTVQNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKGSGERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFVQEFKRKYKKDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGIDFYTSITRARFEELNADLFRSTMEPVEKSLRDAKMDKSQIHDIVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEEVQDLLLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVFEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVEKSTNKENKITITNDKGRLSKEEIERMVNEAEKYRNEDEKQKETIQAKNALESYCFNMKSTMEDEKLKDKISDSDKQTILDKCNDTIKWLDSNQLADKEEYEHKQKELEGICNPIITKLYQGAGGMPGGMPGGMPGFPGGAPGAGGAAPGGGAGPTIEEVD
What are the official names of this protein?
Heat shock 70 kDa protein cognate 4, Hsc 70-4.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEPA_BORPE
Sequence: MQHIRNFSIIAHIDHGKSTLADRLIHRCGGLAEREMSAQVLDSMDIERERGITIKAQTASLQYKSQDGTVYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIELGMEVLPVLNKMDLPQADPEAARQEVEDVIGIDASEAVLASAKTGMGIDEILESIVARVPPPKGDPSAPLQALIIDSWFDNYVGVVMLVRIVNGVLKPKDKILLMASHATHLCEQIGVFTPKSQPRPELSAGEVGFVIAGIKELEHAKVGDTITLAGKPAAEPLPGFKEVKPQVFAGLYPVESSEYDQLRDSLEKLKLNDAALMFEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDMDIITTAPSVVYEVEQRDGTVVTIESPSRMPEIAKIADIREPIVKVTLFMPQEYVGPVMTLCNNKRGVQLNMSYHGRQVHLTYEIPLAEIVLDFFDKLKSVSRGYASMDYEFVEYRSADVVKVDLLINGDRVDALAMIAHRNNARYRAREVVSRMRGLIPRQMFDVAIQAAIGAEVIARENVKALRKNVLAKCYGGDISRKKKLLEKQKAGKKRMKQVGSVEIPQEAFLAILQVEDK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SSTT_PSEMY
Sequence: MSQALHPALQLLNRTSLVMQIFIGLLAGIALALIAPQAALSVGFVGNVFVSALKAVAPVLVFILVMSSIANHQHGQQTHIRPILLMYLIGTFSAALVAVVASFAFPSSLVLSSQAAELTPPGGIGEVLKTLLLNIVDNPVNALLRGNFIGILAWAIGLGFAFRHASPGSKQLLGDLANGVTAIVKLVIRLAPLGIFGLVAATLAESGFDALLGYLHLLVVLVGCMLLVALVINPALVYWKLRRNPYPLVLTCLRESGITAFFTRSSAANIPVNLQLCQRLGLHEETYSISIPLGATINMAGAAITITVLTMAAVHTLGIAVDLPTALLLSVLASISACGASGVAGGSLLLIPLACSLFGIPNEVAMQVVAIGFIIGIVQDSAETALNSSTDALFTAAACMAEEQRQA
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HLDE_SHIBS
Sequence: MKVTLSEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: COA7_DANRE
Sequence: MAGLINFEDEQEVKQFLDNLGVEYSYQCYREKDPEGCHRLADYLEGVKKNYESTAQVLQHNCEVNAHAQSCYKLGAYHVTGKGGMKKCLKTAYSCFLKSCNTQGKKSVDACHNVGLLAQDGRALETGPDTTVARQYFEKACEGGFAPSCFNLSTLYIQGFPGLDKSMPLALKYALKACDLGHVWGCANASRMYKLGDGTDKDEQRAEELKNRAKDLHGQEKERQLKFGE
What is the function of this protein?
May be required for assembly of mitochondrial respiratory chain complexes.
What are the official names of this protein?
Cytochrome c oxidase assembly factor 7, Beta-lactamase hcp-like protein, Sel1 repeat-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the hcp beta-lactamase family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: DOSC_ECOLI
Sequence: MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQVERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILYPVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
What is the function of this protein?
Overexpression leads to an increased level of c-di-GMP, which leads to changes in the cell surface, to abnormal cell division, increased biofilm formation and decreased swimming (the latter 2 in strain W3110).  In a strain able to produce cellulose (strain TOB1, a fecal isolate) overexpression leads to an increase in cellulose production.
What are the official names of this protein?
Diguanylate cyclase DosC, DGC, Direct oxygen-sensing cyclase.