PharMolix/UniProtQA huggingface dataset:
Protein: NUOCD_ECOL5
Sequence: MTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVGDFLKKLPKPYVMLFDLHGMDERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMMPQTWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQNTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRILEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRIRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYA_RHORT
Sequence: MSTTSEIRRTFLDFFVKNGHQEVASSPLVPLNDPTLMFTNAGMVQFKNVFTGAETRPYHRATTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKEQAIDFAWRLITEEYALPKDRLLVTVHTSDEDAAGLWRKVAGLPDERIIRIPTNDNFWAMGDTGPCGPCSEIFFDHGPKVAGGPPGSADENGDRFIEIWNLVFMQFEQLTVDQRVALPRPSIDTGMGLERVAAVLQGKHDNYDIDLMRALIEAIASAAGTDPDGPHKVSHRVIADHLRSACFLIADGVLPSNEGRGYVLRRIMRRAMRHAHMMGCVDPLMFKLVPALNREMADQFPELNRANALITETLKLEETRFKQMLDRGLKLLAEETGDLASGDSLPGPVAFKLYDTYGFPLDLTQDALRPRGIGVDTAGFDAAMARQREDARKSWTGSGDHATEAVWFDIRDRVGASEFLGYTSTDAEGAIVALVVDGKVVESAPADTEVAVIANQTPFYGESGGQMGDAGEIRLAEGGKVVVRDTAKKLGALHVHIGRVEGATIRVGQAARFVVDTERRDALRSHHSATHLLHEALRRRLGEHVTQKGSLVAPDRLRFDISHPKPLSAAEIRVVEDDVNREIRANAEITTQIMDPDSAIEAGAMALFGEKYGEEVRVVSMGRREPGANRPFSVELCGGTHARRTGDIGFFKIIGEGAVASGVRRIEAVTGQAAFEHIEAQDDLVSGAAQLLKVTPADLPGRIQALLDDRRRLERDLADARRKLATGGGGAAAPAVVEINGVKWVGRLLEDVPAKDLKGMVDEVKKQLGSGVVALIAVADGKASLVVGVTEDLVGRFDAVALVRAGAGAIGGKGGGGRPDMAQAGGPDGAQAGAALAAIEAALAG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFPE_SCHPO
Sequence: MDAVEPSVEKEYKKIISFRDTVFEGKHQQFLVPNNVRLKFLRDRLHKSLKNFDSVKRKVEIANDEGNNKLLKSSPKAQTRDENTPSEFKNGGFSNRESMSENCFSKSSTNLPRLDINRDFNSLLNSQTKPEATGLMKEDITPVVNTSKQSSTGTQEESSKPEKSNKLLAKSTLSLYGNQAFNPSSVLPSNSSSTPKENKKNVNKETYQPNTFRRSPLKNDTGSVELSNLYMPSPPSSALPVSLVSAPSPPRATNVAVPCLKHLESSEQGNNLLINKAFTSPRLPSPPQSTRPSSTRFPSVPLSDEKNSIVSVKNEEPSVILGNQSPISDLHPYSPSWIPYPKELQSLQVNRIPELSLENNVMSTRDYKDIMPHPRPSAVLLDKPVSLDQTSHPFPHQNTYILPPGIRNSVDYDGTFLSRKSLPPYNGIHRLHESPSQFSNQSRYNWEPILENRSLLHLNRPPPIETHYSYESNNSSFSPYYHKRHRQISPYYPTSSVYGVYESPPHMSDSRISRQHMPLTHTTYEPSAPYYNDYELAEEIERRRHHSFYDY
What are the official names of this protein?
Uncharacterized protein C7D4.14c.
Protein: XCR1_MOUSE
Sequence: MESSTAFYDYHDKLSLLCENNVIFFSTISTIVLYSLVFLLSLVGNSLVLWVLVKYENLESLTNIFILNLCLSDLMFSCLLPVLISAQWSWFLGDFFCKFFNMIFGISLYSSIFFLTIMTIHRYLSVVSPISTLGIHTLRCRVLVTSCVWAASILFSIPDAVFHKVISLNCKYSEHHGFLASVYQHNIFFLLSMGIILFCYVQILRTLFRTRSRQRHRTVRLIFTVVVAYFLSWAPYNLTLFLKTGIIQQSCESLQQLDIAMIICRHLAFSHCCFNPVLYVFVGIKFRRHLKHLFQQVWLCRKTSSTVPCSPGTFTYEGPSFY
What is the function of this protein?
Receptor for chemokines SCYC1 and SCYC2.  Subsequently transduces a signal by increasing the intracellular calcium ions level.  Receptor for XCL1/Lymphotactin (Probable).
What are the official names of this protein?
Chemokine XC receptor 1, Lymphotactin receptor, SCM1 receptor, XC chemokine receptor 1, mXCR1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NAGK_ECOSM
Sequence: MYYGFDIGGTKIALGVFDSGRQLQWEKRVPTPRDSYDAFLDAVCELVAEADQRFGCKGSVGIGIPGMPETEDGTLYAANVPAASGKPLRADLSARLDRDVRLDNDANCFALSEAWDDEFTQYPLVMGLILGTGVGGGLIFNGKPITGKSYITGEFGHMRLPVDALTMMGLDFPLRRCGCGQHGCIENYLSGRGFAWLYQHYYHQPLQAPEIIALYDQGDEQARAHVERYLDLLAVCLGNILTIVDPDLVVIGGGLSNFPAITTQLADRLPRHLLPVARVPRIERARHGDAGGMRGAAFLHLTD
What is the function of this protein?
Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.
What are the official names of this protein?
N-acetyl-D-glucosamine kinase, GlcNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NagK subfamily.
Protein: GLGB2_STRAW
Sequence: MMTHAGVLGTRFTVWAPNARGVRVCGNFCRWDGAAFPMRSLGSSGVWELFVPGIGEGELYKFEITRPDGTHTVRADPMARRAEVPPATASIVTESSYAWADGAWMAARGERPVHESPFSVYEVHLPSWRPGLTYRQLAEQLPAYVADLGFTHVELLPVAEHPFGGSWGYQVTGFYAPTARLGTPDDFKYLVDALHRAGVGVLMDWVPAHFPRDDWALAEFDGRPLYEPEDPQRAAHPDWGTLEFDYGRKEVRNFLVANAVYWCEEFHIDGLRVDAVASMLYLDYSREEGQWSPNEFGGRDNPDAVAFLQEMNATLYRRVPGVITIAEESTAWDGVTRATHDNGLGFGLKWNMGWMHDSLGYVQHEPVHRKYHHHEMTFSMVYAYSENYVLPISHDEVVHGKQALVSKMPGDWWQRRANHRAYLGFMWAHPGKQLLFMGQEFAQGAEWSPEHGPEWWLLDDEYHSAGDHRGMRDLVRDLNTLYRAEPALWERDTDPSGFAWVVGDAAEDNVFAFLRHAADGTPLLAVSNFSPVVRHDYRLGVPDDIPAWQEALNTDAARYGGSDLICPDPVKPESGEIRLTLPPLATVWLRPA
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB 2, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase 2, Alpha-(1->4)-glucan branching enzyme 2, Glycogen branching enzyme 2, BE 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: NGAL_MOUSE
Sequence: MALSVMCLGLALLGVLQSQAQDSTQNLIPAPSLLTVPLQPDFRSDQFRGRWYVVGLAGNAVQKKTEGSFTMYSTIYELQENNSYNVTSILVRDQDQGCRYWIRTFVPSSRAGQFTLGNMHRYPQVQSYNVQVATTDYNQFAMVFFRKTSENKQYFKITLYGRTKELSPELKERFTRFAKSLGLKDDNIIFSVPTDQCIDN
What is the function of this protein?
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413).  Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context.  Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration.  In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration.  Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis.  Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:15531878, PubMed:16446425).  Can also bind siderophores from M. tuberculosis (By similarity).
What are the official names of this protein?
Neutrophil gelatinase-associated lipocalin, NGAL, Lipocalin-2, Oncogene 24p3, 24p3, SV-40-induced 24p3 protein, Siderocalin LCN2, p25.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
Protein: TSL1_YEAST
Sequence: MALIVASLFLPYQPQFELDTSLPENSQVDSSLVNIQAMANDQQQQRALSNNISQESLVAPAPEQGVPPAISRSATRSPSAFNRASSTTNTATLDDLVSSDIFMENLTANATTSHTPTSKTMLKPRKNGSVERFFSPSSNIPTDRIASPIQHEHDSGSRIASPIQQQQQDPTTNLLKNVNKSLLVHSLLNNTSQTSLEGPNNHIVTPKSRAGNRPTSAATSLVNRTKQGSASSGSSGSSAPPSIKRITPHLTASAAKQRPLLAKQPSNLKYSELADISSSETSSQHNESDPDDLTTAPDEEYVSDLEMDDAKQDYKVPKFGGYSNKSKLKKYALLRSSQELFSRLPWSIVPSIKGNGAMKNAINTAVLENIIPHRHVKWVGTVGIPTDEIPENILANISDSLKDKYDSYPVLTDDDTFKAAYKNYCKQILWPTLHYQIPDNPNSKAFEDHSWKFYRNLNQRFADAIVKIYKKGDTIWIHDYHLMLVPQMVRDVLPFAKIGFTLHVSFPSSEVFRCLAQREKILEGLTGADFVGFQTREYARHFLQTSNRLLMADVVHDEELKYNGRVVSVRFTPVGIDAFDLQSQLKDGSVMQWRQLIRERWQGKKLIVCRDQFDRIRGIHKKLLAYEKFLVENPEYVEKSTLIQICIGSSKDVELERQIMIVVDRINSLSTNISISQPVVFLHQDLDFSQYLALSSEADLFVVSSLREGMNLTCHEFIVCSEDKNAPLLLSEFTGSASLLNDGAIIINPWDTKNFSQAILKGLEMPFDKRRPQWKKLMKDIINNDSTNWIKTSLQDIHISWQFNQEGSKIFKLNTKTLMEDYQSSKKRMFVFNIAEPPSSRMISILNDMTSKGNIVYIMNSFPKPILENLYSRVQNIGLIAENGAYVSLNGVWYNIVDQVDWRNDVAKILEDKVERLPGSYYKINESMIKFHTENAEDQDRVASVIGDAITHINTVFDHRGIHAYVYKNVVSVQQVGLSLSAAQFLFRFYNSASDPLDTSSGQITNIQTPSQQNPSDQEQQPPASPTVSMNHIDFACVSGSSSPVLEPLFKLVNDEASEGQVKAGHAIVYGDATSTYAKEHVNGLNELFTIISRIIED
What is the function of this protein?
Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process.  May stabilize the trehalose synthase complex, and confer sensitivity to physiological concentrations of phosphate and to fructose 6-phosphate.
What are the official names of this protein?
Trehalose synthase complex regulatory subunit TSL1, Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 123 kDa subunit.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the glycosyltransferase 20 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_BURPS
Sequence: MTEQKRKLEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFVDALNGENLTLRPENTAAVVRAAIEHNMLYDGPKRLWYLGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDDLGLTGIKLEINSLGLAEERAAHRVELIKYLEQHVDKLDDDAQRRLYTNPLRVLDTKNPALQEIVRNAPQLIDFLGDVSRAHFDGLQRLLKANNLPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGVERILELLKEEHLVPEQEGVDVYVVHQGDAAREQAFIVAERLRDTGLDVILHCSADGAGASFKSQMKRADASGAAFAVIFGEDEVANGTVSVKPLRGTGAEGEKNVQQSVPVESLTEFLINAMVATAEDGDD
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMQK_ASPFN
Sequence: MEPDTTRRSACDRCRGQKLRCVRLPGPAREDSPRSARSVNQPCERCKRAKVVCYTTKPVSRRLPQSYTRRRSTAYADDVMHSEVDLDEGMIGSNRLRDEPTIKRTPPAIADRLAHDPFPTELWSGLDISHASLDSSAVLSHVPDPGNMVESVAAQRANSNTLPSHQHGWPEDPHGALNYFEERAHDLPDVMSVSSPTDVRLGLDTVDRRPAAATSRTNQAIHSDTVNMHSQAPGSGETSERGLYSRASNTVADAAQLCTTQLSELNMRLMKDIESTTSFRQGMSAASDPNYPASGLGETSPSSSMVKFTNTMLANCQSFLDILQRLRSPTVELRGSSNSECSYGDLEYSSNEYSSSRSQSRNHSTSASSRSKDGRISAGGGLQSVLNSDTIGLSPSLDPIKADSSALDFSAFLSILSCYTHILRAYDALFTEILEMLMESSCIQLDLKIHNLVPEVSLGGFRLSGHGDLQIKCLLHMSFIILEKIESMLGVNAPEKDPYGSNGGLLNNSQLRGLLEALYHQKEFDYIRADGTRAARVKKTMKSIQRILDSI
What is the function of this protein?
C6 finger transcription factor that positively regulates the cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination (PubMed:29182847).
What are the official names of this protein?
C6 finger transcription factor imqK, Imizoquin biosynthesis cluster protein K.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAMKV_DANRE
Sequence: MPFGCLKPGEKKDYNSPTEITDKYDLGQIVKSEEFCEIFRAKDKNTLKMYTCKKFLKKDGRKVRKAAKNEIVILKMVKHPNILQLVDVYETRKEYYLFLELATGREVFDWILDQGYYSERDTSNVIRQVMEAVAYLHSLKIVHRNLKLENLVYYNRLKHSKIVISDFHLAKLENGLIKEPCGTPEYLAPEVVGRQRYGRPVDCWALGVIMYILLSGNPPFYDEADDDDYENHDKNLFRKILAGDYEFDSPYWDEISDSAKNLVSRLMEVDQDQRLTAQEAINHEWISGNAASDKNIKENVCAQIEKNFAKAKWKKAVRVTTMMKRLRAPENQTAAATAPAAEAAAASPSEADPAAGAQETPQAASEASTAPSSTAESLSASIEVPAVEPANAEAASAAVQPPAEPVVHVPEPEQPVPTSRCNGEASALDTVEEQSG
What is the function of this protein?
Does not appear to have detectable kinase activity.
What are the official names of this protein?
CaM kinase-like vesicle-associated protein, 1G5z.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=May be associated with vesicular structures.
Protein: XENA_XENSI
Sequence: MFTFSPSFMFDFELTRILGSASSGGCDVGEFKSALNTIKKNDPESWYAAWKQQAERAQKIADEAAKAGYRVLARNAYLRASNYFRATSYMFNNDDARVIPFTDKSIACFKRATELMDGEVLSVDIPYEDGITLPGYLFLPPQYARVPGKIPVVMYAAGADSTKEELYFLYGGTGPQLGYAILCLEGPGQGLLLKKNKIPLRPDFEVVAAKVLDFLDDLSRSQPALELDLGRIAMAGAATGGYFALRAATDPRIKACVSIDPFFSLWELSLTRVPQAFFKLWDSGWVPDGTFDAFTDRHARGNFQAGWEINLGKSSMGVEKATGMFRRFKQFTLEPEDGTKILDKVTCPVFITGPGSGQEMYASADDSTFKIQRLLTKVPDSKKEIWVPNDVADGGLTAKIGAWALLAQKTFEFLDKHFEVKRKEL
What is the function of this protein?
Alpha/beta hydrolase; part of the gene cluster that mediates the biosynthesis of xenoacremones such as xenoacremone A, a compound that shows inhibitory activity toward the PI3K/AKT signaling pathway and which has the ability to induce apoptosis of A549 lung cancer cells (PubMed:34900544).  Within the pathway, cooperation of the hybrid PKS-NRPS xenE and the trans-acting enoyl reductase xenG is responsible for the formation of the reduced tyrosine-nonaketide derivative (PubMed:34900544).  The alpha/beta hydrolase xenA then accelerates intramolecular nucleophilic attack to give a pyrrolidone derivative (PubMed:34900544).  Subsequently, three enzymes, xenF, xenD, and xenC, coordinately participate in the conversion to xenoacremone B (PubMed:34900544).  XenF catalyzes sigmatropic rearrangement to form an A-ring, which leads to an unusual intermediate with a hexane ring, which is required for the formation of the tricarbocyclic product (PubMed:34900544).  Epoxidation catalyzed by xenD and the formation of the paracyclophane ether catalyzed by xenC initiate a spontaneous intramolecular Diels-Alder (IMDA) reaction to yield xenoacremone B (PubMed:34900544).  Spontaneous hydration of xenoacremone B leads to the formation of xenoacremone A, which undergoes subsequent methylation to afford xenoacremone C (PubMed:34900544).
What are the official names of this protein?
Alpha/beta hydrolase xenA, Xenoacremones biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.
Protein: RB_MOUSE
Sequence: MPPKAPRRAAAAEPPPPPPPPPREDDPAQDSGPEELPLARLEFEEIEEPEFIALCQKLKVPDHVRERAWLTWEKVSSVDGILEGYIQKKKELWGICIFIAAVDLDEMPFTFTELQKSIETSVYKFFDLLKEIDTSTKVDNAMSRLLKKYNVLCALYSKLERTCELIYLTQPSSALSTEINSMLVLKISWITFLLAKGEVLQMEDDLVISFQLMLCVVDYFIKFSPPALLREPYKTAAIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFINSLGIVSSNGLPEVESLSKRYEEVYLKNKDLDARLFLDHDKTLQTDPIDSFETERTPRKNNPDEEANVVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISYFNNCTVNPKENILKRVKDVGHIFKEKFANAVGQGCVDIGVQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTLQHLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKVEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGPDNLEPACPLSLPLQGNHTAADMYLSPLRSPKKRTSTTRVNSAANTETQAASAFHTQKPLKSTSLALFYKKVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFSSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKKLRFDIEGADEADGSKHLPAESKFQQKLAEMTSTRTRMQKQRMNESKDVSNKEEK
What is the function of this protein?
Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:8336704).  The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes.  Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription.  Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase.  RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C.  Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (PubMed:15750587).  Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression.  Controls histone H4 'Lys-20' trimethylation (PubMed:16612004).  Inhibits the intrinsic kinase activity of TAF1.  Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter.  In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex.  Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity) (PubMed:15750587, PubMed:16612004, PubMed:8336704).
What are the official names of this protein?
Retinoblastoma-associated protein, p110-RB1, pRb, Rb, pp105.
What is the protein family that this protein belongs to?
Belongs to the retinoblastoma protein (RB) family.
What are the subcellular locations of this protein?
Nucleus. Note=During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization.
Protein: PTH_PSEA8
Sequence: MTAVQLIVGLGNPGPEYDQTRHNAGALFVERLAHAQGVSLVADRKYFGLVGKFSHQGKDVRLLIPTTYMNRSGQSVAALAGFFRIAPDAILVAHDELDMPPGVAKLKTGGGHGGHNGLRDIIAQLGNQNSFHRLRLGIGHPGHSSLVSGYVLGRAPRSEQELLDTSIDFALGVLPEMLAGDWTRAMQKLHSQKA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_METSB
Sequence: MDNLNRVASGPDVRTLMAEIGREARKAARTLSLASTETKNSALLAAAAAIRTKAGAIAAANAQDYAAAQAKGVAGSFLDRLKLDPSRIEAMARGIAEVAALPDPVGRVLARFERPNGLVIERVAVPLGVIGIIYESRPAVTADAGALCLKAGNAAILRGGSESLRSAALIHDCLVAGLLEAGLPAAAISRVPIADRAAVGEMLSGLNGDIDVIVPRGGKSLVARVQNEARVPVFAHLEGVVHIYIDRAADLAKATKILLNAKLRRTGVCGAAETLLVDRACAATHLAPLVKTLLDAGCAVRGDAAALEADPRVSPASEADWSAEYLDAIISVRLVDGIDGAIAHIEAYGSHHTDCIVTEDPAAADRFLAEVDSAIVMHNASTQFADGGEFGFGGEIGIATGRMHARGPVGVEQLTTFKYRVHGDGQIRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEC1_BOVIN
Sequence: MGRRAWTLQCTAFSLFCAWCAMNSVKAKKQFVNEWAAEIPGGPEAASAIAQELGYDLLGQIGSLENHYLFKHRNHPRRSRRSALHITKRLSDDDRVIWAEQQYEKERSKRSVLRDSALDLFNDPMWNQQWYLQDTRMTATLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDLINENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASLIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISINSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPSTWSSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRIADMSGRIQNEGRIVTWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKVVDSGEEQPTQEGLDENAQASQSPSGSGVGGRRDELAEGAPSEAMLRLLQSAFSKNSPSKQSPKKPPSAKPNIPYENFYEALERLNKPSQLKDSEDSLYNDYVDGFYNTKPYKHRDDRLLQALVDLLREEN
What is the function of this protein?
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.  Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
What are the official names of this protein?
Neuroendocrine convertase 1, NEC 1, Prohormone convertase 1, Proprotein convertase 1, PC1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family. Furin subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
Protein: D2_DICDI
Sequence: MNKLLVFILLLLLLINISFARKRSYIKNTDASIVVTQFGAIKGIVEDTHRVFYGVPFAQPPVNQLRWENPIDLKPWENVRETLTQKSQCAQKCNLGPGVCSPIGTSEDCLYLDVFTPKDATPNSKYPVIVYIPGGAFSVGSGSVPLYDATKFAQSSVIVVNINYRLGVLGFMGTDLMHGNYGFLDQIKALEWVYNNIGSFGGNKEMITIWGESAGAFSVSAHLTSTYSRQYFNAAISSSSPLTVGLKDKTTARGNANRFATNVGCNIEDLTCLRGKSMDEILDAQEKVGLTFGDKILDAFTIWSPVIDGDIIPMQPLTAVKEGKTYDVPTIIGNVKHEAIPFIYSFFQDSVGIDYYRVLVAIVFPLNAMKILPLYPAAPRGQDSRPILSELITDYLFRCPDRYHTVTNAKKLSSPTYHYHYVHVKSTGHSLDACDDKVCHGTELSLFFNSYELMGERLDNDEKELAIDINNYIVNFATTHNPNTGLDVPVQWRQVTSTQNSTLILETTIETKDTFTNDPKCNALDLTYYRNQVRP
What are the official names of this protein?
cAMP-regulated D2 protein.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, esterosome membrane. Note=Membrane-enclosed crystals (esterosome).
Protein: YSO2_ACIAM
Sequence: MFFMALRFLIGGIILLPFAKQLTLNRDIFLLSIFTTLSTSFWAYGLLYVEPSESAVLSYTMPLIAIPLSTLILREKTTKTEVIGILIGFSGVVIYSLNLGIYFSLIGIVLTLINAFFWALFTVYFRKLRGFDATSVNAVQLLLGSLIFFTLSPIQFYFKYSINFLVDLLYVSVLGGGISFYLWNSMLKTERVSKVTVLSFSVPAVSTAVDELRGVNVNIGMIEGIGVMFLGILISRLEKKINKSNIINGRFHV
What are the official names of this protein?
Uncharacterized transporter in sor 3'region, ORF2.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NCAP_CVM3
Sequence: MSFVPGQENAGGRSSSGNRAGNGILKKTTWADQTERGPNNQNRGRRNQPKQTATTQPNSGSVVPHYSWFSGITQFQKGKEFQFAEGQGVPIANGIPASEQKGYWYRHNRRSFKTPDGQQKQLLPRWYFYYLGTGPHAGASYGDSIEGVFWVANSQADTNTRSDIVERDPSSHEAIPTRFAPGTVLPQGFYVEGSGRSAPASRSGSRSQSRGPNNRARSSSNQRQPASTVKPDMAEEIAALVLAKLGKDAGQPKQVTKQSAKEVRQKILNKPRQKRTPNKQCPVQQCFGKRGPNQNFGGSEMLKLGTSDPQFPILAELAPTVGAFFFGSKLELVKKNSGGADEPTKDVYELQYSGAVRFDSTLPGFETIMKVLNENLNAYQKDGGADVVSPKPQRKGRRQAQEKKDEVDNVSVAKPKSSVQRNVSRELTPEDRSLLAQILDDGVVPDGLEDDSNV
What is the function of this protein?
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M.  Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NC, Protein N.
What is the protein family that this protein belongs to?
Belongs to the betacoronavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Protein: RECR_STRP7
Sequence: MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSADDVNEFAKNLLSAKRELTYCSICGRLTDDDPCSICTDSTRDQTTILVLEDSRDVAAMENIQEYHGLYHVLHGLISPMNGISPDDINLKSLMTRLMDSEVSEVIVATNATADGEATSMYLSRLLKPAGIKVTRLARGLAVGADIEYADEVTLLRAIENRTEL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.