PharMolix/UniProtQA huggingface dataset:
Protein: AROB_SHEB2
Sequence: MKQIQVDLGVRSYPIYIGQNLMSDGETLSRYLLKKRILIVTNETVAPLYLKQIQETMASFGEVESVILPDGEQFKDLAHLDTIFTALLQQNYGRDSVLVALGGGVIGDMTGFAAACYQRGIDFIQIPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPQIVLIDTLCLHTLPAREFAAGMAEVIKYGIMWDADFFQWLEDNVTALKTLDAQALIYAISRCCEIKADVVSQDETEQGVRALLNLGHTFGHAIEAEMGYGNWLHGEAVSAGTVLAAQTAKALGLIDESIVCRIIELLQAFDLPVSAPESMDFDSFIQHMRRDKKVLGGQIRLVLPTAIGRADVFSQVTESTLEQVIRCA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADB_ACIB5
Sequence: MIHAGNAITVQMLADGIAEFRFDLQGESVNKFNRATIEDFKAAIAAVKANNDIKGLVVTSGKSTFIVGADITEFGQNFAQGEKAIVDWLMPVHEIFNSFEDLDLPKVAAINGMALGGGFEMCLVCDYRVMSEAAQVGLPEIKLGIYPGFGGSVRLSRLIGIDNAVEWMAMATPKKPAAALKDGAVDAVVAADKLLDAATDLVKQAISGRLNWKAKRQEKLEAVKLNPLEQMMAFNTAKGAVLAKANPAQYPAPKLLLDSLQAGASLARDEALKAEAEGFAKAAVTPQAEALIGLFINDQVVKKASKQHEKGAHPVNQAAVLGAGIMGGGIAYQAASKGTPIIMKDIGNPQLALGMKEANNLLTKQVERKKMKPVQMGETLARIRPTLSYEEFKEVDIVIEAVTENPKVKEIVLAETEKNVRENTIIASNTSTISITRLAKALQRPENFVGMHFFNPVHMMPLVEVIRGEKTSEEAIATTVVLAQKMGKTPIVVNDCPGFLVNRVLFPYFGAFDLLVKDGADFQQIDNVMSKFGWPMGPAYLIDVVGIDTGVHGAEVMAEGFPDRMKPDYKGAIEAMYEAKRLGQKNDVGFYKYELDKKGKKAKTVDPTAYEVIAPFVTGEKREFDNQEIIDRMMLALCNETVRCLEDNIVATASEADMAMIMGIGFPPFRGGPCRYIDQTGVAEYVALCDKYAHLGKAYEAPQMLRDMAANNKKFYG
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: CYVIA_VIODI
Sequence: GIPCGESCVFIPCISSVVGCSCKSKVCYRN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide vdif-A.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: RS21_THISH
Sequence: MPHVRVKENEPFEVALRRFKRTCEKAGVLTEVRRREFYEKPTEIRKRKAAAAVKRQAKRVSKEVARRERLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: MURA1_STAAW
Sequence: MDKIVIKGGNKLTGEVKVEGAKNAVLPILTASLLASDKPSKLVNVPALSDVETINNVLTTLNADVTYKKDENAVVVDATKTLNEEAPYEYVSKMRASILVMGPLLARLGHAIVALPGGCAIGSRPIEQHIKGFEALGAEIHLENGNIYANAKDGLKGTSIHLDFPSVGATQNIIMAASLAKGKTLIENAAKEPEIVDLANYINEMGGRITGAGTDTITINGVESLHGVEHAIIPDRIEAGTLLIAGAITRGDIFVRGAIKEHMASLVYKLEEMGVELDYQEDGIRVRAEGELQPVDIKTLPHPGFPTDMQSQMMALLLTANGHKVVTETVFENRFMHVAEFKRMNANINVEGRSAKLEGKSQLQGAQVKATDLRAAAALILAGLVADGKTSVTELTHLDRGYVDLHGKLKQLGADIERIND
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1, Enoylpyruvate transferase 1, UDP-N-acetylglucosamine enolpyruvyl transferase 1, EPT 1.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEI2_ARATH
Sequence: MDSESESESNPSTTDEFDRFLDAPDEFYYDCLPIRSNSHQPSSLLRRRKSAHRRDLISSDIETEPSSSSDGFDVGEKSSYVEKNAELRGDIDTSDVIESTKDSIDLSSEKENDLDVISSSGNDMDVIDSGRNRVDPFQEESTVTTVSSDDQGDDDYAGSVPQFREPPNSTEWSLLGFLVGLVIKAIEFQVSFMTSLLTFPPWLLRNCFLFFFDPFSTIRFGRRFLMARVAGISDMIFGYMNPFRLKDTKQMLSIVCKFGWGMFWAVYVGIVLFGLLVSSLMIGGYVINRIADKPFEVKETLNFDYTKNSPEAYVPISSCAGVECEGSCKESNEMSKIRGLRVIPRDQKLDIILSMTLPESAYNKNLGMFQVRVDFLSVDGQTIASIRRPCMLRFRSEPIRLVQTFFKVVPLVTGYVSEIQTLSLKLKGFVEKDIPTACLKIIIEQRAEFRPGAGIPELYDASLSVESGLPFFRKIIWKWRKTLFVWISMSLFITELLFTLVCCRPLIIPRTQPRDRSPSNPTGVWR
What is the function of this protein?
Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size.  Supports the formation of small-sized LDs and modulates triacylglycerol accumulation.  Induces probably a reorganization of the endoplasmic reticulum into LD-forming domains.
What are the official names of this protein?
Seipin-2, AtSEIPIN2.
What is the protein family that this protein belongs to?
Belongs to the seipin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized to the lipid droplet-forming sites.
Protein: AMPG_ECO57
Sequence: MSSQYLRIFQQPRSAILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFFGRRRGWLLATQILLLVAIAAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADKWLGWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSITDKHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAVPGLILLLVCRQTLEYTRVNDNFISRTAYPAGYAFAMWTLAAGVSLLAVWLLLLTMDALDLTHFSFLPALLEVGVLVALSGVVLGGLLDYLALRKTHLT
What is the function of this protein?
Permease involved in cell wall peptidoglycan recycling.  Transports, from the periplasm into the cytoplasm, the disaccharide N-acetylglucosaminyl-beta-1,4-anhydro-N-acetylmuramic acid (GlcNAc-anhMurNAc) and GlcNAc-anhMurNAc-peptides.  Transport is dependent on the proton motive force.
What are the official names of this protein?
Anhydromuropeptide permease, AmpG permease, Muropeptide:H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SIX2_HUMAN
Sequence: MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENNENSNSNSHNPLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHGLQDSILNPMSANLVDLGS
What is the function of this protein?
Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach.  During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation.  Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4.  Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1.  During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation.  During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1.  During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway.  May also be involved in limb tendon and ligament development (By similarity).  Plays a role in cell proliferation and migration.
What are the official names of this protein?
Homeobox protein SIX2, Sine oculis homeobox homolog 2.
What is the protein family that this protein belongs to?
Belongs to the SIX/Sine oculis homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MMPL8_MYCTA
Sequence: MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPWVVIAFWVALAGLLAPTVPSLDAISQRHPVAILPSDAPVLVSTRQMTAAFREAGLQSVAVVVLSDAKGLGAADERSYKELVDALRRDTRDVVMLQDFVTTPPLRELMTSKDNQAWILPVGLPGDLGSTQSKQAYARVADIVEHQVAGSTLTANLTGPAATVADLNLTGQRDRSRIEFAITILLLVILLIIYGNPITMVLPLITIGMSVVVAQRLVAIAGLAGLGIANQSIIFMSGMMVGAGTDYAVFLISRYHDYLRQGADSDQAVKKALTSIGKVIAASAATVAITFLGMVFTQLGILKTVGPMLGISVAVVFFAAVTLLPALMVLTGRRGWIAPRRDLTRRFWRSSGVHIVRRPKTHLLASALVLVILAGCAGLARYNYDDRKTLPASVESSIGYAALDKHFPSNLIIPEYLFIQSSTDLRTPKALADLEQMVQRVSQVPGVAMVRGITRPAGRSLEQARTSWQAGEVGSKLDEGSKQIAVHTGDIDKLAGGANLMASKLGDVRAQVNRAISTVGGLIDALAYLQDLLGGNRVLGELEGAEKLIGSMRALGDTIDADASFVANNTEWASPVLGALDSSPMCTADPACASARTELQRLVTARDDGTLAKISELARQLQATRAVQTLAATVSGLRGALATVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGSRQLAEGVQLLVDQVKKMGFGLGEASAFLLAMKDTATTPAMAGFYIPPELLSYATGESVKAETMPSEYRDLLGGLNVDQLKKVAAAFISPDGHSIRYLIQTDLNPFSTAAMDQIDAITAAARGAQPNTALADAKVSVVGLPVVLKDTRDYSDHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLIGSVIVSYLAALGIGVIVFQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLGVRSGVIRTVASTGGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVRTVTVPAIAVLVGQANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEEEEQSPPDDDDLIGLWLHDGLRL
What are the official names of this protein?
Probable transport protein MmpL8.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DCTA_PARDP
Sequence: MHIDTTAAPVAHAPRPFYRHLYFQVLCAIVAGALIGHFYPETGEALKPLGDAFIKLVKMIIAPVIFLTIVTGLAGMGTLKGVGSVVGKAFGYFLTFSTLALVVGLITANVIRPGAGMNIDPASLDASKVADYASKAHESSLTGFVMDIIPSTITSAFVDGNILQVLFVAILFGIGLILIGDKGKPVVALFEAISHAVFRMVDILMKAAPIGAFGAFAFTIGKYGIASVVNLATLVGTFYLTSALFVIVVLGTVCMLNGFSIFRLISYLKAEILLVLGTSSSESALPSLMEKMEKAGCKRSVVGLVVPTGYSFNLDGTNIYMTLAALFIAQATNTDLTLQQQILLLLVAMLSSKGAAGVTGAGFITLAATLSVVPTVPVAGMALILGVDRFMSECRSITNFIGNAVATVVVSRWEGALDREQFDRVLGGEAGGEVAPIHDLHGAPAGLRLNEASAD
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS4_GEODF
Sequence: MARYTGPSCRLCRRENTELFLKGERCYTDKCAIKRRNYPPGQHGQGRSKTSDYGVQLREKQKVRRIYGILENQFRGYFERADRLKGVTGENLLFLLERRLDNIVYRLGFASSRIEARQLVRHGHFTLNGKKVTIPSIQVKTGDTVELREKSRKVASINESLEAVVRRGIPQWLELDKGAFKGSVKTLPVREDITMPIQEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: TSKS_MOUSE
Sequence: MASVVVKTIWQSKEIHEAGDPPAGVESRAQLVPEAPGGVTSPAKGITKKKKAVSFHGVEPRMSHEPMHWCLNLKRSSACTNVSLLNLAAVEPDSSGTDSTTEDSGPLALPGPPASPTTPWAPEDPDITELLSGVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQLKGPRPDVLTQENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKLEAGLSRHGLSPATPIQGCSGPPGSPEEPPRQRGLSSSGWGMAVRTGEGPSLSEQELQKVSTGLEELRREVSSLAARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSARGLQELRGRADELCTMVERSAVSVASLRSELEALGPVKPILEELGRQLQNSRRGADHVLNLDRSAQGPCARCASQGQQLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEAVRAKNLLLTDKMKPEEKVATLDYMHLKMCSLHDQLSHLPLEGSTGAMGGGSNGGAPPKRGSPGSEQ
What is the function of this protein?
May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.
What are the official names of this protein?
Testis-specific serine kinase substrate, Testis-specific kinase substrate, STK22 substrate 1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Concentrates in spermatid centrioles during flagellogenesis. Associates with acrosomal vesicle in sperm. In elongating spermatids, accumulates in a ring-shaped structure originating from the chromatoid body.
Protein: PYRG_SALNS
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQLAVDIGREHALFMHLTLVPYLAAAGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISMKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLSEWEQVIYEEANPAGEVTIGMVGKYIELPDAYKSVIEALKHGGLKNRVTVNIKLIDSQDVETRGVEILKDLDAILIPGGFGYRGVEGKIATARYARENNIPYLGICLGMQVALIEFARNVAGMDNANSTEFVPDCKYPVVALITEWRDEDGNVEVRNEKSDLGGTMRLGAQQCQLSDDSLVRQLYGASTIVERHRHRYEVNNMLLKQIEAAGLRVAGRSGDAQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAANEHQKRQAK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: ERPA_BURL3
Sequence: MNAVTESAATTAEMPVPFVFTDAAADKVKQLIDEEGNPDLKLRVFVQGGGCSGFQYGFTFDEEVNEDDTVMNKNGVQLLIDSMSYQYLVGAEIDYKDDLNGAQFVIKNPNASTTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: MSRQ_BRUA4
Sequence: MAAAAQTGKKKTVRPGEWKIWLLYAVGFVPAVWTFYLGASGNLGADPVKTFEHTLGLWALRFLILTLMVTPIRDLTGMAFLRYRRALGLLAFYYALMHFATYMVLDQGLNISAIVTDIVRRPFITIGMISLVLLVPLALTSNNWSIRKLGRRWNSLHKLVYVAIAGGAIHFIMSVKSWPAEPVIYAGIVSALLLWRLVRPHARNRKPVSRPRGEAMAVKK
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LTV1_RAT
Sequence: MPHRKKKPFIEKKKAVSFHLVHRSQRDPLAADETAPQRVLVPTQKVNDEERRAEQRKYGVFFDDDYDYLQHLREPSGPAELIPSSTPSTYSSRGEEDTSVFPSTGIKLPSSVFASEFEEDVGLLNKAAPVSGPRLDFDPDIVAALDDDFDFDDPENLLEDDFILQASKPTGGEGMDMLESDGDDGNEWEDMDEGGSDGCGSTGPLSDGGDISAPGSPREAMKKHLFWEEETKSRFTEYSMTSSVMRRNEQLTLHDERFEKFYEQYDDVEIGALDNAELEGTIQVDSSRLQEVLNDYYKEKAENCVKLNTLEPFEDQDLAANELDESEKEETVTVVLEEAREKWDCESICSTYSNLYNHPQLIKYEPKPKQIHLSSKTGIPLHVLPKKGLTAKQVERMQMINSSDLPKVSTQPRLKTESKEDKKARKQAIKEERKERRVEKKANKLAFKLEKRRQEKELLNLKKNVEGLKL
What are the official names of this protein?
Protein LTV1 homolog.
What is the protein family that this protein belongs to?
Belongs to the LTV1 family.
Protein: RL1_METM5
Sequence: MDSEKILNAVKEARTLAKPRNFTQSVDLIVNLKELDLSRPENRLKEQIVLPSGRGKDVAIAVIAKGDLAAQAEEMGLTVIRQEELEELGKNKKTAKKIANAHGFFIAQADMMPLVGKSLGPVLGPRGKMPQPVPGNANLAPLVARFQKTVSINTRDKALFQVYIGHESMSDDELAANAEAILNVVSRKYEKGLYHVKSAFTKLTMGAAAPIEK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: RL31B_SALTO
Sequence: MKPGIHPEYRPVVYRDKGADFAFLTRSTSTSDQTIEWTDGNTYPVIDVQISSASHPFWTGKQRLLDTAGRVEKFRQKYARRGPQSG
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: ODO2_PIG
Sequence: MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGISLCQGPGYPDSRKIVISNSSVLNVRFFRTTAVCKDDVITVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPAVSAVPPPPAASIPTQMPPVPSPPQPLTSKPVSAVKPTAAPPVAEPGAVKGLRAEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQDMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVETMNYADIERTISELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHAIVDRPVAVGGKVEIRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
What is the function of this protein?
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (PubMed:10806400).  The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:10806400).  The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity).  A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity).
What are the official names of this protein?
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial, 2-oxoglutarate dehydrogenase complex component E2, OGDC-E2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, E2K, E2o, PE2o.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Protein: EFM7_CANAL
Sequence: MSEDEISIEGDLFEEPEGFLPERPSSHFSTYKRKIPNAEPQEITMKLVGHNPLYGHLLWNAGIYTADYLDKHSDTLVQGKKILELGAASALPSLVCSLNHAKEVIVTDYPDPDLLSHMEYSFNDLKEKTKYELSPWKVKGYIWGHDLGELLFDEPGRKLAEEEKFDLIILSDLVFNHSEHHKLLDTCRQSLKRNGGKCLVVFSPHRPYLLQDDLSFFETAKQYQFKTEKIEMVTWKPMFEEDEETADIRARVYAFFLIPEWE
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.
What are the official names of this protein?
Protein N-terminal and lysine N-methyltransferase EFM7, Elongation factor methyltransferase 7.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_MANSM
Sequence: MSNKIIVALDYETEKEALQLVDQIDPSLCRLKVGKEMFTTLGTNFVKLLQDRDFDVFLDLKFHDIPNTVARAVRSAADLGVWMVDLHASGGLRMMEEAKKILEPYGKDAPILISVTVLTSMEDLDLLQIGINASPMEQVIRLAHLSQRAGLDGVVCSPQEVEILRQHLGKEFKLITPGIRPVGSEFGDQRRVMTPPAAIEAGSDYLVIGRPITQAANPAEVLRSINASIANLIA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: COFC_HALSA
Sequence: MRTVVPFDPRDPKSRLAEFFADAEERRGFAYAMLADVLGAVRDAGGDPVVVATAPVSRPVDAPVTVDDRALSTAVAAAIADGPLPTAVVMADLALATPDAIRRVFAASGDVVLAPGSGGGTNVVLARTADVPVSYHGVSFRDHVTAAERAGLTVTTVDSFRLAADVDDASDLVDVFVHNTRRTREWLIAGGWRLAVDDGTPTVVREPND
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
2-phospho-L-lactate guanylyltransferase, LP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: KDKA_XANCP
Sequence: MVSFDATEALTPYREGRGYGAILFDRERLRQADAGLFSPQRWGDRARPVDEGGRGGAWFVDAPFGHSVLRQYRRGGMAARVSRDQYLWKGAGRTRSFAEFRLMRELLKRKLPVPRPLAACYLREGLGYRAALLMERLENVRSLADHAQVAGRGAPWEDTGRLIARFHRAGLDHADLNAHNILFDAGGHGWLIDFDRGVLRIPATRWRERNLARLHRSLLKLRGNRTREDVDKDYERLHRAYELAWGRGY
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
What are the official names of this protein?
3-deoxy-D-manno-octulosonic acid kinase, Kdo kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. KdkA/RfaP family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CHI2_HEVBR
Sequence: MKEIVRALEGYGPPKDKAAEQCGWQAGGALCPGGLCCSQYGWCANTPEYCGSGCQSQCDGGVGGEGGCVDLGCANTPEYCGSGCQSQCDGGVGGEGGCVDLGSIISRSTFEEMLKHRNNAACPAKGFYTYDAFISAAKAFPAFGTTGDVDTCKREIAAFFGQTSHATTGGWPTAPDGPYAWGYCHKEELNQASSYCSPSPAYPCAPGKKYYGRGPIQLSWNYGQCGQALGLDLLNNPDLVATDRVISFKAAIWFWMTPQFPKPSCHDVITGQWSPTGHDISAGRAPGYGVITNIINGGLECGRGWDARVEDRIGFYKRYCDMFGVGYGSNLDCYNQTPFGLG
What is the function of this protein?
Inactive chitinase-like protein that does not exhibit hydrolytic activity toward chitin (PubMed:25104038).  Binds strongly to chitin and possesses antifungal activity toward the fungal pathogen Altenaria alternata in plate assays (PubMed:25104038).  Probably involved in defense against fungal pathogens through a mechanism that only involves carbohydrate binding (PubMed:25104038).
What are the official names of this protein?
Inactive chitinase-like protein 2, HbCLP2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
Protein: RAS_LACBI
Sequence: MASKFLREYKLVVVGGGGEGKSCLTIQLIQSHFVDEYDPTIEESYRKQCVIDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFEEIMTFQQQILRVKDKDYFPIIVVGNKCDLDKERVVSKQEGESLARQFGCKFIETSAKSRINVENAFYDLVREIRRYNKEMSNPSGFGARAPDSKMDVSEPGESAGCCGKCIVM
What are the official names of this protein?
Ras-like protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: CSK2B_XENLA
Sequence: MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTMR
What is the function of this protein?
Regulatory subunit of casein kinase II/CK2.  As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity).  Participates in Wnt signaling.
What are the official names of this protein?
Casein kinase II subunit beta, CK II beta, Phosvitin.
What is the protein family that this protein belongs to?
Belongs to the casein kinase 2 subunit beta family.
Protein: RPO6_THEVO
Sequence: MKYTKFEKARIIGARALQIAMGAPVIIDIPKNVIDPVDIATIEFENNVIPITIKRVSKVLN
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo6, DNA-directed RNA polymerase subunit K.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.