PharMolix/UniProtQA huggingface dataset:
Protein: NEP_I63A3
Sequence: NTVSSFQDILMRMSKMQLGTSSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQSRSGKWREQLSQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs to which the M1 protein is bound.  Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced (By similarity).
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: PUR7_PSEF5
Sequence: MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGVPTQFDKLLGDNECLVKKLDMIPVECVVRNYAAGSLVKRLGVEEGMKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNEVLSKLFDDAGLLLVDFKLEFGVFSDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVAQRLGVPL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RL9_HALHL
Sequence: MELILLEKVSNLGNLGDRVRVRPGYGRNYLLPYGKAKMATEENIRYFEERRAELEKAAREAEQAAQARLEQLQELTLTIKAKVGEQGKLFGSVGPADIAEAAEQAGVELARREVRMPEGPIRVAGEYDVQVSLYTDVEGTVKVVVEGDAS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: WASL_BOVIN
Sequence: MSSGQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQINNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHSSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPGVGAPPPPPNRMYPPPLPALPSSAPSGPPPPPPPLSVSGSVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTPAGSKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVTDAPESTPPAPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDDEDFEDDDEWED
What is the function of this protein?
Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:17609109).  Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization.  Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia.  In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity).  Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.  Plays a role in dendrite spine morphogenesis (By similarity).
What are the official names of this protein?
Actin nucleation-promoting factor WASL, Neural Wiskott-Aldrich syndrome protein, N-WASP.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated. Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm.
Protein: CAB3_YEAST
Sequence: MTDEKVNSDQNMNGKQGVNLISSLPTTQVPVSILTNKERRKSIHDESNFERSDSHEDQSKSNSNRRNIYKNDYSTNLRDFSFANLKQNSERNKDGHEIQINTSMPANTNGQQKRFSPSLPSAVSFTVPEVERLPYHRYSISNKPGKQQQQQEQLQQNQQQEEQQKAQLQEQNQRAKQQEEVKQIQEQVQKKQTERQQLIDEKERIANAIFKENTTNDGTDIRKHSVSSGTSNSEDEVDSPSMEKNSIVHMPGDFIYFNPKSNASKPITAKAAPLSANNSTHKNKEVITAPTGPRVPFTEFFQKEDDKKFHILIGATGSVATIKVPLIIDKLFKIYGPEKISIQLIVTKPAEHFLKGLKMSTHVKIWREEDAWVFDAVNKNDTSLSLNLILHHELRKWADIFLIAPLSANTLAKLANGICNNLLTSVMRDWSPLTPVLIAPAMNTFMYINPMTKKHLTSLVQDYPFIQVLKPVEKVLICGDIGMGGMREWTDIVEIVRRRINEIRKARDEETGDKEQEQEEQEGADNEDDDDEDDEEDEEDEEEEEALNETASDESNDEEDEEDEEDVKTEV
What is the function of this protein?
Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis.
What are the official names of this protein?
Coenzyme A biosynthesis protein 3.
What is the protein family that this protein belongs to?
Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSPC1_SHIFL
Sequence: MNISETLNSANTQCNIDSMDNRLHTLFPKVTSVRNAAQQTMPDEKNLKDSANIIKSFFRKTIAAQSYSRMFSQGSNFKSLNIAIDAPSDAKASFKAIEHLDRLSKHYISEIREKLHPLSAEELNLLSLIINSDLIFRHQSNSDLSDKILNIKSFNKIQSEGICTKRNTYADDIKKIANHDFVFFGVEISNHQKKHPLNTKHHTVDFGANAYIIDHDSPYGYMTLTDHFDNAIPPVFYHEHQSFLDKFSEVNKEVSRYVHGSKGIIDVPIFNTKDMKLGLGLYLIDFIRKSEDQSFKEFCYGKNLAPVDLDRIINFVFQPEYHIPRMVSTENFKKVKIREISLEEAVTASNYEEINKQVTNKKIALQALFLSITNQKEDVALYILSNFEITRQDVISIKHELYDIEYLLSAHNSSCKVLEYFINKGLVDVNTKFKKTNSGDCMLDNAIKYENAEMIKLLLKYGATSDNKYI
What is the function of this protein?
ADP-riboxanase effector that mediates arginine ADP-riboxanation of host caspases (PubMed:34671164, PubMed:35338844).  ADP-riboxanation of host apoptotic caspases (CASP3, CASP8 and CASP9) prevents their activation, thereby inhibiting host cell extrinsic and intrinsic apoptosis (PubMed:32657447, PubMed:35338844).  Does not catalyze ADP-riboxanation of host CASP4/CASP11 (PubMed:34671164).  Independently of its ADP-riboxanase activity, acts as an inhibitor of calcium signaling by inhibiting host calmodulin, preventing activation of the JAK-STAT signaling pathway in response to interferon-beta (PubMed:35568036).  Mechanistically, acts by binding to the apo form of calmodulin, preventing calcium-binding and ability to activate host CaMK2 (CAMKII), which is required to stimulate the JAK-STAT signaling pathway in response to interferon-beta (PubMed:35568036).
What are the official names of this protein?
Arginine ADP-riboxanase OspC1.
What is the protein family that this protein belongs to?
Belongs to the OspC family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Note=Secreted via the type III secretion system (TTSS).
Protein: PYRF_BACSU
Sequence: MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGPSIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEGLEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVVCSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSITKAEDPVKAYKAVRLEWEGIKS
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: H8H01_CYRHA
Sequence: MVNMKASMFLTFAGLVLLFVVCYASESEEKEFPKEMLSSIFAVDNDFKQEERDCAGYMRECNEKLCCSGYVCSSRWKWCVLPAPWRR
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U3-theraphotoxin-Hhn1p, U3-TRTX-Hhn1p, Hainantoxin-VIII-8, HNTX-VIII-8.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8) subfamily. Hntx-8 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YHT8_YEAST
Sequence: MKASYLVLIFISIFSMAQASSLSSYIVTFPKTDNMATDQNSIIEDVKKYVVDIGGKITHEYSLIKGFTVDLPDSDQILDGLKERLSYIESEYGAKCNLEKDSEVHALNRDHLVA
What are the official names of this protein?
Uncharacterized protein YHR138C.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I9 family.
Protein: LPTD_PSEA8
Sequence: MAVKSLVFRRKFPLLVTGSLLALQPVAALTVQAADQFDCKVSATGGWDCSPLQNANANLPPRPAHTATSVSTAAAGSSVSGSGGETVEAEPTQRLVTESGGRALKSRSADYSHLDWIPREKLTAAQLAEIGPYCGGSYIEPVRPGMDDGAPSDESPTYVSAKASRYEQEKQIATLAGDVVLRQGSMQVEGDEANLHQLENRGELVGNVKLRDKGMLVVGDHAQVQLDNGEAQVDNAEYVIHKAHARGSALYAKRSENAIIMLKDGTYTRCEPSSNAWTLKGNNVKLNPATGFGTATNATLRVKDFPVFYTPYIYFPIDDRRQSGFLPPSFSSTSDTGFTLVTPYYFNLAPNYDATLYPRYMAKRGMMLEGEFRYLTHSSEGTVNAAYLNDKDDHRENFPDYSKDRWLYGLKNTTGLDSRWLAEVDYTRISDPYYFQDLDTDLGVGSTTYVNQRGTLTYRGDTFTGRLNAQAYQLATTTDVTPYERLPQITFDGFLPYEPGGVKFNYSTEFVRFDRDLDDNIYLNDDGSEWGRRPDAYLQGLARSTGDRVHLEPGMSLPMTRSWGYLTPTLKYLYTKYDLDLDSQGKRTLTTYDETFDSSQDRSLPLVKVDSGLYFDRDTTLAGTQFRQTLEPRAMYLYVPYKDQENIPVFDTSEPSFSYDSLWRENRFSGRDRIGDANQLSLGVTTRFIESNGFERASLSAGQIYYFRDRRVQLPGLSEKDLALMRSKNPNLDLKDPDTDSWRSPYALMGQYRFNRDWRVSSDFNWNPNTSRTESGSAMFHYQPEDNPNKVVNAGYRYREDSRRFNSSTGRFEYGRENDIIKQHDFSVIWPLVPQWSVLARWQYDYNKNRTLEAFGGFEYDSCCWKLRLINRYWLDVDDDAFLNQNEKADRGIFLQIVLKGLGGIVGNKTEMFLDKGIQGYRQREDQAM
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: KCNA5_RABIT
Sequence: MEIALGPLENGGAMTIRGGGEETAGCSQAAPTAGLGDGSQEPAPRGRGCSARRGAEPGERPLPPQPPELPQSRRSPLEEEEGEGDPGLSVAEEQTLGAGALHHQRVLINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKDEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFKDERELLRHPPVPHQPPAAPALGANGSGAVAPASGSTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEPGSQSRGTSLDAGGQRKASWSKASLCKAGGSLETADSVRRGSCLLEKYNLKAKSNVDLRRSLYALCLDTSRETDL
What is the function of this protein?
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.  Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient.  The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:7556635).  Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity).  Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:7556635).  Homotetrameric channels display rapid activation and slow inactivation (PubMed:7556635).  May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity).
What are the official names of this protein?
Potassium voltage-gated channel subfamily A member 5, Voltage-gated potassium channel subunit Kv1.5.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LSRB_ECODH
Sequence: MTLHRFKKIALLSALGIAAISMNVQAAERIAFIPKLVGVGFFTSGGNGAQQAGKELGVDVTYDGPTEPSVSGQVQLINNFVNQGYNAIIVSAVSPDGLCPALKRAMQRGVRVLTWDSDTKPECRSYYINQGTPAQLGGMLVDMAARQVNKDKAKVAFFYSSPTVTDQNQWVKEAKAKIAKEHPGWEIVTTQFGYNDATKSLQTAEGILKAYSDLDAIIAPDANALPAAAQAAENLKNDKVAIVGFSTPNVMRPYVERGTVKEFGLWDVVQQGKISVYVADALLKKGSMKTGDKLDIKGVGQVEVSPNSVQGYDYEADGNGIVLLPERVIFNKENIGKYDF
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
What are the official names of this protein?
Autoinducer 2-binding protein LsrB, AI-2-binding protein LsrB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 2 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: FLGH_VIBVU
Sequence: MKRISLIALVTIMSGCTMLEPIETPEVVNATTVVDAVEGDKSKDESSGIVDTLRGRSDPVAGDPAWAPIHPKQQPEHYAAETGSLFSVNHLSNLYDDSKPRGVGDIITVTLDEKTNASKSANADLSKSNDSSMDPLEVGGQELKIDGKYNFSYNLTNSNNFTGDASAKQSNSISGYITVEVIEVLANGNLVIRGEKWLTLNTGDEYIRLSGTIRPDDISFDNTIASNRVSNARIQYSGTGTQQDMQEPGFLARFFNVSL
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: KTHY_BRUMB
Sequence: MSGLFITFEGGEGAGKSTQIALLASHLRNHGFDPVITREPGGSPGAEAIRHVILSGNAETYGPAMEALLFAAARADHVDQLIRPTLAEGRIVLCDRFIDSSRAYQGVTGNLDATYMAAIERIAIDGAMPDLTLVLDICAERGLSRAGKRRGSDTADRFEKEDIAVHEARRQAFLEIARQEPARCKVIDADRSQEKIADEIRSVVDTILTEKGLL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RL32_XANC8
Sequence: MAVQKSRVTPSRRGQRRSHDALTAKQLSTDPTSGEIHLRHHITADGYYRGKKVITTKSSAVQED
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: LACA_STAA9
Sequence: MAIIIGSDEAGKRLKEVIKSYLLDNKYDVVDVTEGQEVDFVDATLAVAKDVQSQEGNLGIVIDAFGAGSFMVATKIKGMIAAEVSDERSGYMTRGHNNSRMITMGSEIVGDTLAKNVVKGFVEGKYDGGRHQIRVDMLNKMC
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacA.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: IDH3A_RAT
Sequence: MAGSAWVSKVSRLLGAFHNTKQVTRGFAGGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPPEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTQSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSLTKDLGGNSKCSDFTEEICRRVKDLD
What is the function of this protein?
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate.  The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
What are the official names of this protein?
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitric dehydrogenase subunit alpha, NAD(+)-specific ICDH subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NUSB_MYCTA
Sequence: MSDRKPVRGRHQARKRAVALLFEAEVRGISAAEVVDTRAALAEAKPDIARLHPYTAAVARGVSEHAAHIDDLITAHLRGWTLDRLPAVDRAILRVSVWELLHAADVPEPVVVDEAVQLAKELSTDDSPGFVNGVLGQVMLVTPQLRAAAQAVRGGA
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: FIC_ECOLI
Sequence: MSDKFGEGRDPYLYPGLDIMRNRLNIRQQQRLEQAAYEMTALRAATIELGPLVRGLPHLRTIHRQLYQDIFDWAGQLREVDIYQGDTPFCHFAYIEKEGNALMQDLEEEGYLVGLEKAKFVERLAHYYCEINVLHPFRVGSGLAQRIFFEQLAIHAGYQLSWQGIEKEAWNQANQSGAMGDLTALQMIFSKVVSEAGESE
What is the function of this protein?
Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity).  Involved in cell filamentation induced by cyclic AMP.  May have some role in cell division.
What are the official names of this protein?
Probable protein adenylyltransferase Fic, Cell filamentation protein Fic.
What is the protein family that this protein belongs to?
Belongs to the fic family.
Protein: PDXH_SHEPC
Sequence: MTDLSDIRREYAKGGLRRADLPQNPMDLFALWMTQARDAELSDPTAMCVATVDEQGQPFQRIVLLKRFDDTGFVFFTNLGSRKAQQIAANNKVSLHFPWHPLERQVSVLGEAQALSTTEVLKYFMTRPKDSQIAAWVSQQSSKLSARQVLEGKFFEMKAKFAKGDVPLPSFWGGYLVRPKSIEFWQGGEHRLHDRFIYTLDNTQWIIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: OBG_DECAR
Sequence: MKFIDEAKIYIKAGDGGNGAATFRREKYIPMGGPNGGDGGRGGSIYAVADRNINTLVDYRYTRKFIGKRGENGGGADQYGAGGDDIILRMPVGTVIYNLNTEEIIADLSEHDQKVMIAKGGKGGLGNIHFKSSTNRAPRQKTNGEQGEELELRLELRVLADVGLLGLPNAGKSTLIRAISSARPKVADYPFTTLHPNLGVVRVDDEKSFVMADVPGLIEGAADGAGLGIRFLKHLQRTRILLHLVDIAPIDPDSDPVRDAKAIVGELIKHDPDLANKPRWLVLNKLDLIPEEDREAAVKNFIKAYKKATKYDGPVFPIAAINGEGTKPLIYAISEALEQMARPEIGDLDDNDEDSDEIIRDTE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYT1_CROAD
Sequence: MHSRLPVPASLCLLLLLPSVLPASMPGGLSPRDVTDPEVQEAAVFAVEEYNARSTNSNYFKALRLVQAESQVVSGAKYYLTMELVKTSCRKTNGNPKGYQEIQNCRLPPRNQQEKLTCHFEVWSRPWLNKTLLTKVTCN
What is the function of this protein?
Inhibits various C1 cysteine proteases including cathepsin L, papain and cathepsin B.  This protein has no toxic activity and its function in the venom is unknown.  It may play a role as housekeeping or regulatory protein (By similarity).
What are the official names of this protein?
Cystatin-1.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TAB2_HUMAN
Sequence: MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
What is the function of this protein?
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122).  Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122).  The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:22158122).  Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity).  Involved in heart development (PubMed:20493459).
What are the official names of this protein?
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TAB-2, TGF-beta-activated kinase 1-binding protein 2.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol (PubMed:10882101). Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome (PubMed:24434549).
Protein: AAMA1_AMAEX
Sequence: MSDINATRLPIWGIGCNPCVGDDVTSVLTRGEALC
What is the function of this protein?
Major toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters (PubMed:24050899).
What are the official names of this protein?
Alpha-amanitin proprotein 1.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: KCNRG_BOVIN
Sequence: MSGQELVTLNVGGKVFTTRSSTLQQFPGSRLMRMLDGRDKEFKMVDGQIFVDRDGVLFSFILDFLRTQQLLLPTDFSDHLRLQREALFYELNPLVDLLNQEHKLQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFIEQPSAPASSSNSFPQMTLLPLPPQRPSYHDLVFQCGSDSTTDNQTRIRYISIKPDNRKLANGTNVLGLLIDTLLMEGFHLVGTRTVSSEDRTECYSFERIKKPDALAMNKTLKSETTLMPEQ
What is the function of this protein?
Inhibits potassium fluxes in cells.  May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (By similarity).
What are the official names of this protein?
Potassium channel regulatory protein, Potassium channel regulator, Protein CLLD4.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: P5CR_CAEEL
Sequence: MTIDTELTNGSSESVPFVFIGGGNMAAAIIKGCQNKGFTPKSNIVIGVQTEKSAEKWRQLGYKNVFTNTLEMLERYSTAIYVICVKPQVFEEVVSSWPVNSRPEFIISVMAGVPLKVLNAKLPFVSGNTTIVRLMPNVASSIGAGASTMCYEKNEKIMNQDSHIELAREFAECVGTVELIPERCFNPAMAIGGSSPAWTFMYIESLADGAVAQGLGRAEAKRLAAQAVLGAAQMVLNSNSGFDIETQHFGSLKDMVCSPGGTTIEGVRALEKNGFRYAVMEAVVAASTKADEMAKSLAK
What are the official names of this protein?
Putative pyrroline-5-carboxylate reductase, P5C reductase, P5CR.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.