PharMolix/UniProtQA huggingface dataset:
Protein: FYCO1_MOUSE
Sequence: MASSSTETQLQRIIRDLQDAATELSHEFKEGGEPITDDSTSLHKFSYKLEYLLQFDQKEKASLLGSKKDYWDYFCACLAKVKGANDGIRFVRSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTEVQFDLAPRGYDLDAAWPTFARRTLATSTSAYMWKPPSRSSSMSSLVSNYLQTQEMASSLDLNCSLNNEALESFDEMRLELDQLEVREKQLQERVQQLDRENQALRMLVSRQGGQLQVEKEMGYLAVEDSIGLVSLVAELQKQGDVSQATVKKLQSCLQALELNVDKKEYSPSALQLENMAKELDTVRGSLGRENQLLASLSERLARAEKGEKTPPDTELHQEPVPADLVLKFQELKGKLQALEGENTEAQELNRQQSIKLEQLAKELQLKEEARASLAHLVKDVVPLQEELSGKKQESAQLRRQLQESLAHLSSVEEELAEARQQEKQHREEKQLLEQEATSLTWQLQLLETQLGQVSQLVSDLEEQKKQLMQERDHLSQRVGTLEQLAEVHGPPQSAEMPEKRQQCLREEQVNNSTVSEAEQEELQKELQNMVDRNQLLEGKLQALQTDYKALQQREAAIQGSLASLEAEQASIRHLGNQMEASLLAVKKAKETMKAQVAEKEAALQSKESECQRLQEEADQCRLQAEAQAQELRALENQCQQQIQLIEVLSAEKGQQGLSLPQVNTDQLALSQAQLEIHQGEAQRLQNEVVDLQAKLQVALGDRDKLQSQLGVAETVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGILQEESIYKAQKQEQELRALQAELSQVRCSSEGAHLEHAELQDQLHRANTDTAELGIQVCALTAEKDRMEEALASLAQELQDSKEAALQERKGLELQVMQLQQEKEKLQEKVKAAEEAASSFSGLQAQLAQAEQLAQSLQETAHQEQDALKFQLSAEIMDHQNRLKTANEECGHLRAQLEEQGQQLQMTKEAVQELEITKAAMEEKLNCTSSHLAECQATLLRKDEESTMLQTSLERTQKELEKATSKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEEKCLGDMEVNHCHDCKREFSWIVRRHHCRICGRIFCYYCCNNYVVTKPSGKKERCCRACFQKFGEGSGSNDSSGSGTSQGEPSPMVSPAEASPQSIGSQGINSVCRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSMDPNTAEQDTTSNSLTPEDTEDVPMGQDAEICLLKSGELMIKLPLTVEEVASFGEGSRELFVRSSTYSLITITVAEPGLTISWVFSSDPKSISFSVVFQETEDTPLDQCKVLIPTTRCNSHKENIRGQLKVRIPGIYLLIFDNTFSRFISKKVLYHLTVDRPVIYDGSDFP
What is the function of this protein?
May mediate microtubule plus end-directed vesicle transport.
What are the official names of this protein?
FYVE and coiled-coil domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.
Protein: PDXB_STUS1
Sequence: MHILADENIPLVDEFFAGLGEIRRMPGRRINRAALEGVDVLLVRSVTRVDRELLQGTAVRFVGTCTIGTDHLDLDYFEQSGIDWASAPGCNARGVVDYVLGCLLALAEVRGEALARRRFGVVGAGEVGGRLVEVLRGLGWDVRVCDPPRQTREAGGFVTLDEVIAECDVISLHTPLSMSGDCPTFHLFDRQRLSGLRPGAWLINASRGAVVDNAALRDLLLQRPDLEAVLDVWEGEPQVDVELADLCRIATPHIAGYSLDGKLRGTAQIHAAYCAARGLEPTVELAQLMPGPALAGLTFAASAEPAEMLATLCRAVYDPRRDDADFRRSLQGDDAQRRAAFDLLRKAYPARREIDGLAVRIEGDNPALTAVVSALGARLLR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
Protein: MDH_YERP3
Sequence: MKVAVLGAAGGIGQALALLLKTQLPSGSDLSLYDIAPVTPGVAVDLSHIPTAVNIKGFSGEDATPALQGADIVLISAGVARKPGMDRSDLFNVNAGIVRNLVEQIARTCPNALIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGITTLDTIRSNTFVAELKGKQPQDIEVPVIGGHSGVTILPLLSQIPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGESNVVECSYVEGDGKYARFFAQPILLGKNGVAERKDIGKLSAFEQQALENMLDVLHKDIELGEKFVNQ
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: FMAH_ASPFU
Sequence: MLGLPNELSGSQVPGATEYEPGWRRVFKVEDLPGLGDYHIDNQTAVPTSIVCVIALAAAMDISNGKQANSIELYDVTIGRPIHLGTSPVEIETMIAIEPGKDGADSIQAEFSLNKSAGHDENPVSVANGRLRMTFAGHELELLSSRQAKPCGLRPVSISPFYDSLREVGLGYSGPFRALTSAERRMDYACGVIAPTTGEASRTPALLHPAMLEACFQTLLLAFAAPRDGSLWTIFVPTQIGRLTIFPNSSVGINTPASVTIDTHLHEFTAGHKADLPMIKGDVSVYSSEAGQLRIRLEGLTMSPIAPSTEKQDKRLYLKRTWLPDILSGPVLERGKPVFCYELFGLSLAPKSILAATRLLSHRYAKLKILQVGTSSVHLVHSLCRELGSSMDSYTIACESDSSMEDMRRRLLSDALPIKYVVLDIGKSLTEGDEPAAGEPTDLGSFDLIILLKASADDSPILKRTRGLIKPGGFLLMTVAATEAIPWEARDMTRKAIHDTLQSVGFSGVDLLQRDPEGDSSFVILSQAVDHQIRFLRAPFDSTPPFPTRGTLLVIGGASHRAKRPIETIQNSLRRVWAGEIVLIRSLTDLQTRGLDHVEAVLSLTELDQSVLENLSRDTFDGLHRLLHQSKIVLWVTYSAGNLNPHQSGAIGLVRAVQAETPDKVLQLLDVDQIDGNDGLVAESFLRLIGGVKMKDGSSNSLWTVEPELSVQGGRLLIPRVLFDKKRNDRLNCLRRQLKATDSFEKQSALARPIDPCSLFSPNKTYVLAGLSGQMGQSITRWIVQSGGRHIVITSRNPDKDDLWTKELEQRGAHIEIMAADVTKKQEMINVRNQILSAMPPIGGVANGAMLQSNCFFSDLTYEALQDVLKPKVDGSLVLDEVFSSDDLDFFLLFSSISAVVGQPFQANYDAANNFMTGLVLQRRARNLPASVINLGPIIGLGFIQNIDSGGGSEAVIATLRSLDYMLVSERELHHILAEAILIGKSDETPEIITGLETVSDNPAPFWHKSLLFSHII
What is the function of this protein?
Stereoselective keto-reductase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2) (PubMed:23488861, PubMed:24568283).  Within the pathway, the keto-reductase af490 acts as a 5-dehydrofumagillol 5-reductase that stereoselectively reduces 5-keto-fumagillol to 5R-hydroxy-seco-sesquiterpene (PubMed:24568283).  The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520.  The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps.  5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene.  The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin.  Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (PubMed:24568283) (Probable).
What are the official names of this protein?
Stereoselective keto-reductase af490, 5-dehydrofumagillol 5-reductase, Fumagillin biosynthesis cluster keto-reductase, Fma-KR.
Protein: SYFA_YERPA
Sequence: MPHLAELVAKAKAAVEGAQDIAALDLVRVEYLGKKGHLTLQMTSLRELPAEERPAAGAVINQAKQEIQEALNARKEKLESAVLNARLAAETIDVSLPGRRMENGGLHPVTRTIERIETFFGELGFSVESGPEIEDDYHNFDALNIPAHHPARADHDTFWFDATRLLRTQTSGVQIRTMQEQQPPIRIIVPGRVYRNDYDQTHTPMFHQMEGLIVDRDISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEIYSGFAFGMGMERLTMLRYGVTDLRAFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PABC_BACSU
Sequence: MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLDWHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFVAQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREIGNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDIGLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKEIKNMIHEKGGRAWRSTQ
What is the function of this protein?
Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate.  Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate (By similarity).
What are the official names of this protein?
Aminodeoxychorismate lyase, 4-amino-4-deoxychorismate lyase, ADC lyase, ADCL.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: HEM1_AERS4
Sequence: MSLLALGINHNTASVALRERVAFGPDCIDRALRELVTQPGVSEAVIVSTCNRTELYCSLEKGQGEQVLHWLQRFHGLDAAEVVSAIYQHQDEEAVRHLMRVACGLDSLVLGEPQILGQIKQSYAHAQQSEAVKGSLERLFQKSFSVAKRVRTDTEIGASAVSVAFAAVSLGRRIFSDLSQTKVLLVGAGETIELVARHLREQNVTRMMVANRTLQRAQLLAEEFGAQVMTLEEIPDYLHEADIVISSTASPLPIIGKGMVERALKARRFKPMFLVDIAVPRDIEAEVDELSDAYLYTVDDLQGIIEQNLETRKRAAAEAEIIVLEERDEFMGWYRSQHSVDLIRDYRHQAQQVADEELQRALLSLQQGENAEQALKAMAHRLTNKLIHAPTQALRQAAAQGDHHQLSRLRQVLGLPQE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: UXT_RAT
Sequence: MATPPKRRALDTVGEKVLRYEAFISDVLQRDLQKVLDHRDKVYEQLSVYLQLRNVIERLQETNHSELYMQVDLGCNFFVDTMVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDSLTKDSMNIKANIHMMLEGLRELQGLQNFPEPSPH
What is the function of this protein?
Involved in gene transcription regulation.  Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription.  Together with URI1, associates with chromatin to the NKX3-1 promoter region.  Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm.  May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity.  Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling.  Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC.  Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM.
What are the official names of this protein?
Protein UXT, Ubiquitously expressed transcript protein.
What is the protein family that this protein belongs to?
Belongs to the UXT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localizes to the nucleus. Localizes to spindle pole during mitosis.
Protein: SWET1_XENLA
Sequence: MDWMWLLSGACIVFTLGMFSSGLSDLRVMVAQRSVENIQYLPFLTTDLNNLGWFYYGYLKGDGTLMIVNVIGASLQSLYMGAYLLYSPERRYVGSQVLVSLGVLLLGYCYFTLWILDLNSRLNQLGLFCSVFTISMYLSPLADLAQIIRSKSTKCLSFPLTVATFLTSSSWVLYGLVQSDLYITVPNFPGIVTSLVRFWLFSQFPPDPPTYRLLQA
What is the function of this protein?
Mediates sugar transport across membranes.
What are the official names of this protein?
Sugar transporter SWEET1, Solute carrier family 50 member 1.
What is the protein family that this protein belongs to?
Belongs to the SWEET sugar transporter family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: CLPP_HELAN
Sequence: MPIGVPKVPFRSPGEEDASWVDIYNRLYRERLLFLGQEVDSEISNQLIGLMIYLSIEDDTQDLYLFINSPGGWVIPGVALYDTMQFVQPDVHTICMGSAASMGSFILVGGEITKRLAFPHARVMIHQPAGSFSEVATGEFILEVGELLKLRETLTRVYVQRTGKPVWVVSEDMERDVFMSATEAQAYGIVDLVAVE
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RNH_NEIMA
Sequence: MNQTVYLYTDGACKGNPGAGGWGVLMRYGSHEKELFGGEAQTTNNRMELTAVIEGLKSLKRRCTVIICTDSQYVKNGMENWIHGWKRNGWKTAAKQPVKNDDLWKELDALVGRHQVSWTWVKGHAGHAENERADDLANRGAAQFS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HI, RNase HI.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDM34_YEAS7
Sequence: MSFRFNEAVFGDNSFNERIREKLSTALNSPSKKKLDILKSGIKVQKVDFPTIPQLEILDLDIITQPKSLAKGICKISCKDAMLRIQTVIESNLLLINEQDTPSFTMPQLINNGSFTIPITMTFSSIELEAITNIFVKNPGIGISFNDVDLDFKFDCSVKILQSTIERRLKESMHVVFKDVLPSLIFNTSQNWFTNRGESTSTIPGKREHHHQQTTMSRNVILDGSDFQELSPINMLRLSSIVSSRSTLSLHSTVMNSLSAIPGCLERQNLYRFISRMPSLNNYYSSQSFPQPKSSTVSSKQLVKPFYCSHNLLPKTVLDSSQYDLATITKIQSRLFDRSNSNDDNAKPRRRKIKCKKTRTPSNLQSQGEQAVDDSTAIETVTSTPVQTPIPELEEQSPPYLKTTVSIRDKYVIPEKISLNLDSKKDTSKKKPFYFIGLNSQEPSNNWKWGMEDSPPPYH
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34, Mitochondrial outer membrane protein MMM2.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
Protein: MDH_SHELP
Sequence: MKVAVLGAAGGIGQALALLLKTQLPAGSKLSLYDIAPVTPGVAVDLSHIPTAVEVKGFAGEDPTPALEGADVVLISAGVARKPGMDRSDLFNINAGIVRNLVEKCAATCPKALIGIITNPVNTTVAIAAEVLKAAGVYDKNRLFGVTTLDVIRSETFVAEAKGLNVADVKVNVIGGHSGVTILPLLSQIEGVSFSDEEVAALTTRIQNAGTEVVEAKAGGGSATLSMGQAACRFGLSLVRGLQGEANVVECAYVDGGSEHADFFAQPVLLGKNGIEQVLAYGEVSEFEANARDAMLDTLKADITLGVDFVK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: MTR1L_MOUSE
Sequence: MATVPKSNMGPTKAVPTPFGCIGCKLPKPDYPPALIIFMFCAMVITVVVDLIGNSMVILAVTKNKKLRNSGNIFVASLSVADMLVAIYPYPLMLYAMSVGGWDLSQLQCQMVGLVTGLSVVGSIFNITAIAINRYCYICHSLQYKRIFSLRNTCIYLVVTWVMTVLAVLPNMYIGTIEYDPRTYTCIFNYVNNPAFTVTIVCIHFVLPLIIVGYCYTKIWIKVLAARDPAGQNPDNQFAEVRNFLTMFVIFLLFAVCWCPVNVLTVLVAVIPKEMAGKIPNWLYLAAYCIAYFNSCLNAIIYGILNESFRREYWTIFHAMRHPILFISHLISDIRETWETRALTRARVRARDQVREQERARACVAVEGTPRNVRNVLLPGDASAPHSDRASVRPKPQTRSTSVYRKPASIHHKSISGHPKSASVYPKPASSVHCKPASVHFKPASVHFKGDSVYFKGDTVHYRAASKLVTSHRISAGPSTSHPTSMAGYIKSGTSHPATTTVDYLEPATTSHSVLTAVDLPEVSASHCLEMTSTGHLRADISASVLPSVPFELAATPPDTTAIPIASGDYRKVVLIDDDSDDSDCSDEMAV
What is the function of this protein?
Does not bind melatonin.
What are the official names of this protein?
Melatonin-related receptor, G protein-coupled receptor 50, H9.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MYZAP_MOUSE
Sequence: MLRSTSTVTLFSGGGAKSPGTPSRRANVCRLRLTVPPENPVPQQTEKKIERKDQPPELSNGESTKRLPQGVVYGVVRRSDPNQQKEMVVYGWSTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQDLSVSHAQQDYLDSHIQAQASALDSFNAMNAALASDSVGLQKTLVDVTLENSHIKDQIRHLQQTYEASMDKLREKQRQLEAAQMENQLLKMRVESSQEANAEVMREMTRKLYSQYEEKLQEAQRKHSAEKEVLLEETNSFLKAIEEANKKMEAAELSLEEKDQKIGELDRLIERMEKERHQLQLQLLEHETEMSGEMADSDKNRYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQPKTEVETREIGVGCDLLPSPTGRTREITMPSRSYTPYTRVLELSSKKTLT
What is the function of this protein?
Plays a role in cellular signaling via Rho-related GTP-binding proteins and activation of transcription factor SRF.  Targets TJP1 to cell junctions (By similarity).  In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).
What are the official names of this protein?
Myocardial zonula adherens protein.
What is the protein family that this protein belongs to?
Belongs to the MYZAP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, Z line. Cell junction. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin.
Protein: CAPSD_CPVBM
Sequence: MHSTNNNSNKRNNEEKHKQPEIDSSANNGEGTSGTRAQTVGDTATEAGVRNETEAGASTRRQTDGTGLSGTNAKIATASSARQADVEKPADVTFTIENVDDVGIMQQKKPPTVVQSRTDVFNEQFANEALHPTTKVIFNGLDVNTEVQPLSDDFKQISDPKGYLTYSVKYEDQFTKKDKLRASEADDRIVGPTVNLFKYGAAVVNIDLNRDFFDTATGIDLTKGIPLVQDLLVPIGVTAGAEQSAEYVSGLLMVLFKVMTDNRLVIVGETTTPMSNTLSTVVNNVLRTTYHNNVGVNPALLRDFTQVNWLNRDITNMLQQAGTKYGLGLTETRLDYVRLVKTIVGHALNIDHFAASVLNINLRALMEANVTADDRIKALQAHSMISTQFHGPNQGALRPELAFDHDHIIRCLMLAAANYPRLEGIIVQINTGYVASANVIRPVSEKRYFPENLEQNQSAARLVSAVKARASEADISSIHLAIAREVSPMFNVHELKKIAESFEDPSSIVVVLEFILFALFFPTEFNRIKGDIQNVLLLFFSRWYPVEYGIFVQRGATYTINAAGEFEFSGRNEKWDQALYLSEHFPALFSDVPLAGANTIIAIMRLFTPQGFLRTDDLAIAANFPRASRNPQTYIPYTNQRGTVTNEFASRFRTIVATLANVVNERAVQDDMQKATRSCTKQWLRHLETQFDNIAVAHTDHLSVVYATMSNFMLNFTNNFSGNHATFKPDQYVITSPEGSYKPIIERQGETVDGLTIIDTSIVWPILCQCTYPLVRQSGKGVDAVSIMEEIVYPDPSTTLSQSLSVAQVLSKLTLPDAFINMILSGGDSVVMRTYQTEADDDLDEGIRMTTYDQYLSHIRERLHITNVPDPIYITGASTPDQIAASVQATHVAVVLYQSGVINGPASTYLRENEVLVVMPDYYDVVSRFANANLQMNNNRYHESVLEIADIFDQADFIQTSDAVRQLRALMPTLSTSQIRHAIERIAQITDVDSTDYGKLTLRFLGTLTRSLKMQNAQIRRIRPDGTVLRYDDQIDIEAFRWSRYFLDELQLRRLSVGLRLITNPRIARRFNGVRIMYLTDDDPDPDFVPDVPEGYVAVQYAHRLFSSSLANKRNRVTYTHPPTGMAYPSPTGRPHVHMTINERAGMSKLVADNIIASVIKSNWVVDILDIEYTAEVMTPSEGYTQHVDAESIMTAPKGKLFHLQFMDGLLRPEPSAFDPPASGEDMRLIYPLQPISVARSMRAIVNHNEVDRPRGAVAPSSYEMDTGTLSRNGDLLYSPVANGQVGIPKLEVDHISFSNVVSMMTANIRTGDDMAVERVNPDDVRAINIRNA
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a pseudo T=2 symmetry, about 50 nm in diameter, and consisting of 120 capsid proteins.  The capsid encapsulates the genomic RNA.
What are the official names of this protein?
Capsid protein VP1.
What are the subcellular locations of this protein?
Virion.
Protein: ERF1_XENLA
Sequence: MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYENLDTMRYVLRCNGSEEEKTLYLTPEQEKDKSHFIDKETGQEHELIESMPLLEWFANSYKKFGATLEIVTDKSQEGSQFVKGFGGIGGILRYRVDFQGMDYQGVDDEFFDLDDY
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:7990965).  Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity).  Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes.
What are the official names of this protein?
Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, eRF1, Omnipotent suppressor protein 1 homolog, SUP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_HERA2
Sequence: MTAPNQDDFLLVGRISAAFGVRGELKISMISSHPEHIQKLKQLFVGDLSKPYTIGRLHQHKGSLYLLRLNEVDTRDAAEAMQGLEAYIHRSDAAPLANDEYFLHDLVGLQVQTEAGEDIGRAVEIIETGANDVLVVRKLGQADILVPMVRTVVRSIDIAGGTITVTSLADIVPE
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_DESHD
Sequence: MERTQRKVRVGKVVSDKMEKTIVVAVEMKVRHPLYHRTITQTKKFKAHDENNEAKIGDSVVIMETRPISKDKRWRLVEITERAVVL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: 3SA3A_NAJAT
Sequence: MKTLLLTLVVVTIVCLDLGYTLKCNKLVPLFYKTCPAGKNLCYKMFMVATPKVPVKRGCIDVCPKNSLLVKYVCCNTDRCN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pore in lipid membranes.  In vivo, increases heart rate or kills the animal by cardiac arrest.  In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
What are the official names of this protein?
Cytotoxin 3a, Cardiotoxin-31, Ctx-31, Cardiotoxin-3a.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: QUEC_PARPJ
Sequence: MIRKDAKRSALVLFSGGQDSATCLAWALERYETVETLGFDYGQRHRVELECREGFRNAVARAFPAWAERLGDDHMIDLSVLGAISDTAMTREIEIEATANGLPNTFVPGRNLMFMTIAAAIAYRRGLQVLVGGMCETDFSGYPDCRDDTMKALQVALNLGMDTRVLLETPLMWLDKGDTWRLAHQLGGDELVELVRVETHTCYVGERAELHAWGFGCGECPACRLRKRGYEAYLSGEKVTEAPV
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: DDL_PAEAT
Sequence: MVTDHSTPVTGRPRVAILFGGRSSEHAVSCVTAAGVMGAIDKNKYEVIPIGIAKSGQWVLASGDTSEWSLSSAALPEVAPSGRTVTLAEVGGEHQLIVTEPNAVPQELGSVDVVFPLLHGPWGEDGTIQGLLELSDTRYVGAGVLASAVGMDKHFMKVVFESAGLSVGPYVAVTDREWSTDAEAVRKRVDKLGFPVFVKPARAGSSMGISKVDSMEGLDAAIDEARRHDLKLVIEAGIVGREIECAVLQGRGTDAPRTSMPGEIAVAVGEHQFYDFAAKYVEDGAAALSCPADMPDEAIARVRELAAVAFDAVGAEGLSRVDFFYTPAGELIINEINTMPGFTPKSMYPQMWAASGLAYGDLIDELIHLALTRKTGLR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQ7_POLNS
Sequence: MSPIDRLILEFDTALRSVVGGANAQRPTPGSEFASNSGVDAAERKHAAGLMRVNHVGEVCAQALYQSQKLVARNSEIQAMLDYSGQEEMDHLAWCENRLQELGSHTSYLNPLWYAGSFAIGLAAGLAGDKWSLGFVAETEKQVESHLESHLKKLPKEDQRSRAIVDQMRIDEIAHGQAAKNAGGVNLPEPIQKIMHAMSKVMTTTAYKI
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL16_PORG3
Sequence: MLQPKKTKFRRQQKGRMKGFAQRGNQLSFGSFGIKSLQSKWITGRQIEAARIAVTRYMQRQGQVWVRIFPDKPITKKGEGVRMGKGKGAPEGFVAPITPGRIIFEVEGVPYEIAKEALRLAAQKLPVTTKFVVRHDYDIQNQNA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.