PharMolix/UniProtQA huggingface dataset:
Protein: CSK2D_ARATH
Sequence: MYKERSGGGGGGSSRSEILGGAIDRKRINDALNKKLEKSSTSTTTSRVFSSKDKDPFSFTSTKTQLPDVESETDSEGSDVSGSEGDDTSWISWFCNLRGNDFFCEVDEDYIQDDFNLCGLSGQVPYYDYALDLILDVDASNSEMFTDEQHEMVESAAEMLYGLIHVRYILTTKGMAAMTEKYKNCDFGRCPRVFCCGQSCLPVGQSDIPRSSTVKIYCPKCEDISYPRSKFQGNIDGAYFGTTFPHLFLMTYGNLKPQKPTQSYVPKIFGFKVHKP
What is the function of this protein?
Plays a complex role in regulating the basal catalytic activity of the alpha subunit.  The tetrameric holoenzyme CK2, composed of two alpha and two beta subunits, phosphorylates the transcription factor PIF1 after an exposure to light, resulting in a proteasome-dependent degradation of PIF1 and promotion of photomorphogenesis (PubMed:21330376).  CK2 phosphorylates translation initiation factors.  May participate in the regulation of the initiation of translation (PubMed:19509278).  Stimulates the binding of CCA1 to promoters (Probable).
What are the official names of this protein?
Casein kinase II subunit beta-3, CK II beta-3.
What is the protein family that this protein belongs to?
Belongs to the casein kinase 2 subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: FLVB_ASPFN
Sequence: MRYLITGATGGLGGHILEYFIAQIPFSDFAASSSSPENRSRFESRGVNFRHLDYENPTTLNRALHDVENLLFISTNANVIDVEKVKRQHRNVVEAARKANVKHVWYTSLPFGGLTNDSEVSVQRAHLATEKMLKESGLTFTCIREGIYVEGFPLFLNWYPETTLLTLPRDGEIAFTSRVELAVCTARLMIQGGFENRIVLLTAGETITAKELVSVINETTGRRVELRYVSPDEFVDAGPRNDRGGKSRAFFETLVSLWESAASGELRTMDGLMAEILGRDPIPPRDAVRQLLVENRDHTWHQMYAKK
What is the function of this protein?
NmrA-like family domain-containing oxidoreductase; part of the gene cluster that mediates the biosynthesis of flavunoidine, an alkaloidal terpenoid with a tetracyclic cage-like core connected to dimethylcadaverine via a C-N bond and acylated with 5,5-dimethyl-L-pipecolate (PubMed:31885262).  The tetracyclic core is synthesized by the terpene cyclase flvE and the cytochrome P450 monooxygenase flvD (PubMed:31885262).  The terpene cyclase flvE catalyzes the cyclization of farnesyl pyrophosphate (FPP) to form (1R,4R,5S)-(+)-acoradiene and the cytochrome P450 monooxygenase flvD is then responsible for oxidative conversion of (1R,4R,5S)-(+)-acoradiene into the tetracyclic cage present in the final product flavunoidine (PubMed:31885262).  In parallel, the N-methyltransferase flvH dimethylates L-lysine to give N,N-dimethyl-L-Lysin which is decarboxylated by flvG to afford dimethylcadaverine (PubMed:31885262).  The terpene cyclase-like protein flvF is the enzyme that attaches the dimethylcadaverine precusor at the C-7 of the tetracyclic cage to yield pre-flavunoidine (PubMed:31885262).  The cytochrome monooxygenase flvC hydroxylates the C-10 position of pre-flavunoidine whereas the NRPS flvI acylates the terpenoid core at the hydroxylated C-10 with dimethylpipecolate to yield final flavunoidine (PubMed:31885262).  The bifunctional enzyme flvA and the dehydrogenase flvB are responsible for the synthesis of the dimethylpipecolate precursor (PubMed:31885262).  The PLP-dependent lyase domain of flvA might use L-O-acetyl-homoserine and alpha-keto-isovalerate to form an intermediary ketone that can cyclize intramolecularly to yield an imine (PubMed:31885262).  The imine can be reduced by flvB to yield the 6-carboxylated pipecolate (PubMed:31885262).  The C-terminal alpha-KG-dependent oxygenase domain of flvA is then proposed to catalyze the decarboxylation to yield dimethylpipecolate (PubMed:31885262).
What are the official names of this protein?
NmrA-like family domain-containing oxidoreductase flvB, Flavunoidine biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family.
Protein: TBK1_XENLA
Sequence: MQSTANYLWMLSDILGQGATANVYRGRNKKTGDLYAVKVFNSLSFQRPADVQMREFEVLKKLNHKNIVKLFAIEEEMSSRHKVLVMEFCPCASLYSVLEEPTNSYGLPESEFLIVSRDVVAGMNHLRENGIIHRDIKPGNIMREIGEDGKSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKEHQKKYSATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIAGKPSGAISGVQRAENGPIEWSGELPATCNLSMGLQTLFTPVLANILEADQEKCWGFEQFFAVTNDIFNRIVVHVFSLQQMTPHKIYINTYDKVPDFHDLVYKQTKIPGQNQELLFEGRRLVLEQGRLAQHFPITTDENPIFVLTREMVSVIGLRFDEIVIPKPISHYDLDVDANMAKAVTGVACYYCRIAASLLLVLDLMRKGIRWLSELMKEEYNENVHRNTEVSLKLNFCNRTTEKDLKIYEQLMQTSVESEVYAIHAKLLNLSSTQEGLKSSLQEVKNKLTPGGTLMDSWINTEGIHAADRNVEKLQVLLSLITEIYCQFKKDKAQRRLSYNEEQIHKFDKQKLCLHAAKAYSLFKDECVGKYEVFRSKTLEWMRKMIHVRKQLFSIKSKCFDIEEEASKCQHYINQYQEKMSPKMFAAPSGMKSAVNPIYSSPNTLVEMTLGMRKLKEDMEGVVKELEENNHILERFGALTIDGDFRNVDCI
What is the function of this protein?
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents.  Following activation of toll-like receptors by viral or bacterial components, associates with traf3 and tank and phosphorylates interferon regulatory factors (IRFs) irf3 and irf7 as well as ddx3x.  This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including ifna and ifnb.  In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli.
What are the official names of this protein?
Serine/threonine-protein kinase TBK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_BUCAI
Sequence: MAKQSMKAREVKRVKLANKFYTQRHELKNIISNMSISEEERWNAVLKLQSFPRDSSPSRQRNRCRQTGRPHAFLRKFGLSRIKVREAAMKGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RRF_SINFN
Sequence: MSEGVELKELKRRMDGAIAAFKHDIASLRTGRASANVLDPVTVEAYGSRMPLNQVANIMVPEPRMLSVSVWDKTMVGAVDRAIRESNLGLNPIIDGQNLRIPLPELNEERRKSLVKVAHDYAEKSKVAVRHVRRDGMDGLKKAEKDGDIGQDESRAQSERVQKMTDEVISEIDRLLAEKEKEIMQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CXCL6_HORSE
Sequence: MSLLPSRAARVPGPSSSLCALLALLLLTPPGPLVSAGPVAAAVRELRCMCLTVTPGIHPKMISSLQVFAVGPQCSKVEVVPTLKNKKEVCLDPEAPLIKKFIQKTLDSGNKKN
What is the function of this protein?
Chemotactic for neutrophil granulocytes.  Signals through binding and activation of its receptors (CXCR1 and CXCR2).  In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity).
What are the official names of this protein?
C-X-C motif chemokine 6, Granulocyte chemotactic protein 2, GCP-2, Small-inducible cytokine B6.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: BMPR2_HUMAN
Sequence: MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL
What is the function of this protein?
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.  Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.  Binds to BMP7, BMP2 and, less efficiently, BMP4.  Binding is weak but enhanced by the presence of type I receptors for BMPs.  Mediates induction of adipogenesis by GDF6.
What are the official names of this protein?
Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RS14_STRA1
Sequence: MAKKSKIAKFQKQQKLVEQYAELRRELKEKGDYEALRKLPKDSNPNRLKNRDLIDGRPHAYMRKFGMSRINFRNLAYKGQIPGIKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: UBL5_CAEEL
Sequence: MIEITVNDRLGKKVRIKCNPSDTIGDLKKLIAAQTGTRWEKIVLKKWYTIYKDHITLMDYEIHEGFNFELYYQ
What is the function of this protein?
Involved in the mitochondrial unfolded protein response (mtUPR) (PubMed:17925224).  Plays a role in modulation of lipid metabolism in response to the citrate-induced mtUPR, acting upstream of transcription factor nhr-80 (PubMed:35021096).
What are the official names of this protein?
Ubiquitin-like protein 5.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_CARHZ
Sequence: MKEPLVMYREGFWYLVALGVLTVLGALINFWLGLLVFLLFLFVVFFFRNPRRTIPEDEKAIISPADGVVLDVAEVNESYYLKGPAVKISIFLSIFDVHVNRAPVEGQVEYVYYREGKFLPAFKSHASEINERNYIGIKNPYLQVLVVQITGFIARRIVSFVKPGDILKKGQLLGMIKFGSCTEIYLPKETVEVLVQKGQRVYGGITVIGRIKG
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: VME1_CVHN1
Sequence: MNKSFLPQFTSDQAVTFLKEWNFSLGVILLFITIILQFGYTSRSMFVYLIKMIILWLMWPLTITLTIFNCFYALNNAFLAFSIVFTIISIVIWILYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGKMFVRPVIEDYHTLTATVIRGHLYIQGVKLGTGYTLSDLPVYVTVAKVQVLCTYKRAFLDKLDVNSGFAVFVKSKVGNYRLPSSKPSGMDTALLRA
What is the function of this protein?
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
What are the official names of this protein?
Membrane protein, M protein, E1 glycoprotein, Matrix glycoprotein, Membrane glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses M protein family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer.
Protein: HBB_HETPO
Sequence: VHWSEVELHEITTTWKSIDKHSLGAKALARMFIVYPWTTRYFGNLKEFTACSYGVKEHAKKVTGALGVAVTHLGDVKSQFTDLSKKHAEELHVDVESFKLLAKCFVVELGILLKDKFAPQTQAIWEKYFGVVVDAISKEYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SUCC_WOLPP
Sequence: MNIHEYQAKEILHKFNVPVPKGFVATSAEGVETQINQLKSDVFVVKAQIHAGGRGKAGGVKLAKSVEEAQQFVKNMLGITLVTHQTGPSGQQVRRIYIEEGSSIKKEYYLSLVVDPKLSRLVFIFSSEGGMDIEEVAKNSPTKIVKFDIDPATGFTNLDNSKLANNFNLNSEQIERITNIAKNIYDAFITTDASQIEINPLVETNSGDFVALDAKINFDDNALYRHPEIVQLRDYDEEVKEEIEASKHGLSYIKMDGNIGCMVNGAGLAMATMDIIKYYGAEPANFLDVGGGASKETVTEAFKIILSDSNVKGILVNIFGGIMRCDIIASGIVAAAKEMSIKVPLVVRLSGTNFEEGKKILEESGLNIIAADELGDAAQKIVKEVK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RL29_TOLAT
Sequence: MKAQDLRQKSVEELKTELLGLLRAQFNLRIQKSTGQLNQTHTIKQVRRDIARVKTVLNEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: YIDC_PHOPR
Sequence: MDSQRNILLIALLFVSFLLYQQWNMDNSPQPQGQGTEQQVNNSGDVPSHSGDGQPIPDQETTSKDLITINTDVLALSVDTLGGDVIEAKLLAYNNELDSADSFILLKDEPGLSYIAQSGLIGANGIDSANGRAQLAVTAKDFTLADGQDELRVPMTYVKDGITYTKTFVLKRNSYAVDVEYTIDNQSASAASVQMYAQLRQNLMDDGGSLTMPTYRGGAYSTDTTNYKKYSFDDMQDKSLNMTTTNGWAAMLQHYFVSAWIPRSEEASNLYTRASNGLGYIGVRLPTTTIAAGTEQTLTATLWVGPKLQKEMEATAANLNLTVDYGWLWFIASPLHKLLSFIQSIVGNWGLAIMMLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLTAMRERLGDDRQRMSQEMMELYKKEKVNPLGGCLPIVLQMPIFIALYWSLMESVELRHSPFFGWIHDLSAQDPYYILPLLMGVSMFMIQKMSPTTVTDPMQQKIMTFMPVMFTFFFLFFPSGLVLYWLVSNVVTLLQQTLIYRSLEKKGLHTK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEA_CAMJJ
Sequence: MNKDLLLSSYDYTLANELIANYPANPKEDARLLVFDRKNKEIFHTTFKNLKDFLPDCAIFFNDTKVIKARIYGNKASGGKIELFLHQPFLNSHNPLFLAQIKGRVKKDEILYFKEDLKARVVELLDDGLRKVQFFQNDKTLDTSNLYNLLDKIGHIPLPPYIKREDEKSDLKDYQSIFAKNLGAVAAPTASLHFSETMFENLRKKHKIYHLTLHVGAGTFKGVECENIQEHKMHSEFFNIPQQACEIIDSKQAILGVGTTVTRTIEYYARTKTKSGFCDLFLHPQNPPIRQNHLLTNFHLPKSTLIMLVSAFIGREQCLKLYKLAIKEKYRFYSYGDAMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOCD_PSEMY
Sequence: MTADTAVSIPPYQVDDQDVIAELRARLGDDGFTLQATRTGMPVLWVSRERLLEVLKCLRHLPRPYVMLYDLHGVDERLRTQRRGLPDADFTVFYHLMSLERNSDLMVKVALSERDLNLPTATGIWPNANWYEREVWDLYGITFQGHPHLTRIMMPPTWEGHPLRKDYPARATEFDPFSLTLAKQQLEEEAARFRPEDWGMKRGGEHEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDCVPEIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLAVEKLAGIKVPDRVDFIRVMLAEFFRITSHLLFLGTYIQDVGAMTPVFFTFTDRQRAYKVIEAITGFRLHPAWYRIGGVAHDLPRGWDKLVKEFVDWLPRRLDEYEKAALKNSILKARTIGVAQYNTKEALEWGTTGAGLRATGCDFDLRKARPYSGYEHFEFEVPLAANGDAYDRCMVRVEEMRQSIRIIDQCLKNMPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPAGEALQMIEATKGINSYYLTSDGSTMSYRTRIRTPSFAHLQQIPSVIRGSMVADLIAYLGSIDFVMADVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MNTP_CORGB
Sequence: MPFLQIFLLSIGVAADAFACSVVRGTAIRVNLFKRALVLAGIFGVFQAAMPLIGWVIGRFFAGITFIAEIDHWIAFALLGVVGAKMIWDAFQPEDDETIVDDGRVQFRPAIILGLATSIDALAVGMGLAFVEVSILKVALSMGLITFALSLVGAWIGHHGGGKFGKWATILGGIILIGIGANIVYEHLSA
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARP2_DROME
Sequence: MDSKGRNVIVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEVKDLHVDDLMVGDEASQLRSLLEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKMIEVMFEKYGFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRIMKEKLCYIGYDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEAPEALFQPHLINVEGPGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQLYLERVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQGLKVLQKLQKISH
What is the function of this protein?
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Seems to contact the pointed end of the daughter actin filament (By similarity).
What are the official names of this protein?
Actin-related protein 2, Actin-like protein 14D, Actin-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MUTL_CLOB8
Sequence: MKRINILNEDTANKIAAGEVVERPASVVKELIENSIDANAKNIIIEIEEGGISLIRIIDDGDGIYKDDIAKAFLPHATSKIQESEDIYNIHTLGFRGEALPSIASVGKVNLKSKQDEEAFGYEISIEGGKASEVTECGINKGTILEVQDLFFNVPARKKFLKSVSKESSLINDIVTRLSLANPKISFKLYNNHKKVLHTFGNGDLKDVIRTIYGKSITDNILYFSDSSDLITVYGYVGTEEIARGSRNNQSIFVNRRYIKNRALAIAVEQAFKSFSTVNKFPFFILFIEVYPEYVDVNIHPTKAEIKFNDERMIFKKIFGAVHTALKNEVFETFAIKEEENTKKEPLPTFEEITFKIKEEEEKVKFASSAAKTLISQGKDLKANNESSFKSVYDPSLNNINKTIVEESTDYNKENEEPISIPVDLKPNSYIENLVDDYSDNAEDEIKSNSEPIENVITENKYENIKPNPIAKFPPITIIGQYNKTYILGEYDGTLYMIDQHAAHEKILFEKYLKEIEEGTIIIQPLIVPSIIDLSIDDYSYFEENKDIFREAGFLLEEFGGSSLSLKEVPYFLGRLNPKNLFLDILDNLKNLGNGKTSEVKHNAIATKACKAAIKGNDKLEMNEMIKLIEDLRYIDDPFHCPHGRPVIIKFTSIDIDKKFKRII
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: YPOL_THETH
Sequence: IIQRSRFLAKAAPAASEEEALAFLAAHREPQATHNAYAYRIGPLYRFSDDGEPRAPGRPILHAIEAAGLDRVVVLVVRYFGGVKLGAGGLVRAYGGVAAEALRRAPKAPLLDWVEVAFRVPFPEVGRVHGLLRARHLEAEEAYLPEGVRFALRLPPGGEGGPCLKALSDLTRGRLWVEG
What are the official names of this protein?
IMPACT family member in pol 5'region.
What is the protein family that this protein belongs to?
Belongs to the IMPACT family.
Protein: TSAD_BURA4
Sequence: MLVLGIESSCDETGLALYDTQRGLLAHALHSQIAMHREYGGVVPELASRDHIRRALPLLEEVMAQSGTHRDDIDAIAFTQGPGLAGALLVGASIANALALAWNKPTVGIHHLEGHLLSPLLVDEPPPFPFIALLVSGGHTQLMRVTDVGVYETLGETLDDAAGEAFDKTAKLIGLGYPGGPEVSKLAETGTPGAVVLPRPMLHSGDLDFSFSGLKTAVLTQMKKFEAAKLESEALERAKADLARGFVDAAVDVLVAKSLAALKQTKLKRLVVAGGVGANRQLRAALSAAAAKRGFDVHYPDLALCTDNGAMIALAGALRLGRWPEQANADYAFTVKPRWDLASLAR
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBB_VIBCH
Sequence: MNQSSLLAEFGDPITRVENALQALREGRGVLLLDDEDRENEGDIIYAVESLTTAQMALMIRECSGIVCLCLTEAQADRLALPPMVVNNNSANQTAFTVSIEAKHGVTTGVSAQDRVTTIKTAANPQAKPEDLARPGHVFPLRARAGGVLARRGHTEGTVDLMQMAGLQPAGVLCELTNPDGSMAKTPEIIEFGKLHNMPVLTIEDMVQYRIQFDLKLA
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: GL41_ORYSJ
Sequence: MASRAFAAVFAAVALVVCSSVLPRALASDPSQLQDFCVADKLSAVFVNGFVCKNPKQVTANDFFLPKALGVPGNTVNAQGSAVTPVTVNELPGLNTLGISFARIDFAPNGQNPPHTHPRATEILTVLQGTLLVGFVTSNQPGGGNLQFTKLLGPGDVFVFPQGLIHFQLNNGAVPAVAIAALSSQNPGVITIANAVFGSTPPILDDVLAKAFMIDKDQVDWIQAKFAAPPAASGGGGGFIGGGGGGGFPGGGAP
What is the function of this protein?
May play a role in plant defense.  Probably has no oxalate oxidase activity even if the active site is conserved.
What are the official names of this protein?
Germin-like protein 4-1.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: UPPP2_FRAAA
Sequence: MHELTYLQAGVIGLLQGITELFPVSSLGHSVLIPALIGGSWQHLVTENASGNSEGSPYLTFVVGLHVATAVALLVFFRSDWARVIRAFLTTLRTRRIETSAQRLAWLIVAATVPVGIIGLALEHTFRTLFAKPLAAALFLTANGMILLAGERLRRRSEQRAGTHQASARAEPATIPLTVPAPATVPTQTTSAPGGRATARHTTAPRGGLVVSEHRSLDTLAYREAGVIGLFQTLALLAGISRSGITMVAGLLRGLDHEDAARFSFLLATPVILAAGLLKLPALAGPAGDGIRGQVILGALIAGIAAYLSIRFLVRYFETRTLTPFAIYCLLTGALCTVRFAIA
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 2, Bacitracin resistance protein 2, Undecaprenyl pyrophosphate phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.