PharMolix/UniProtQA huggingface dataset:
Protein: IHH_MOUSE
Sequence: MSPAWLRPRLRFCLFLLLLLLVPAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLENGERVALSAVKPGDRVLAMGEDGTPTFSDVLIFLDREPNRLRAFQVIETQDPPRRLALTPAHLLFIADNHTEPAAHFRATFASHVQPGQYVLVSGVPGLQPARVAAVSTHVALGSYAPLTRHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFPSLAWGSWTPSEGVHWYPQMLYRLGRLLLEESTFHPLGMSGAGS
What is the function of this protein?
The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.  Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity).  Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (PubMed:10465785, PubMed:10631175).  Positively regulates PTHLH during endochondral bone formation preventing chondrocyte hypertrophy.  In contrast, Ihh is necessary for normal chondrocyte proliferation in a PTHLH-independent pathway (PubMed:10631175).
What are the official names of this protein?
Indian hedgehog protein, IHH, HHG-2.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
[Indian hedgehog protein N-product]: Cell membrane; Lipid-anchor. Note=The N-product remains associated with the cell surface. SUBCELLULAR LOCATION: [Indian hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Secreted. Note=Co-localizes with HHAT in the ER and Golgi membrane.
Protein: PURL_CHLCH
Sequence: MKHTDIEVTLTHAEEHGLSAEEFSQICTILGRTPTITELGIFSVMWSEHCSYKNSIAVLKTLPREGGALLTSAGEENAGLVDIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIFTMGARPVASLNSLRFGSPKDPRVRYLVDGVVRGIGDYGNSFGVPTVAGDIYFEEGYTGNPLVNAMSVGIVEHHKTVSATAYGTGNPVLIVGSSTGRDGIHGATFASEDLSEASEEKRPSVQVGDPFAEKLLLEATLEAIETGYVVGLQDMGAAGITSSTSEMSARGIEKYGVGGIEIDLDLVPIREAGMSAYEIMLSESQERMLIVAAKGFEDKIIEVYQKWDVQAVVIGEVTDDNHVRVKHQGQVVANIPAISLVLGGGAPVYKREAKEKKPETPLANMVADSTLNFNELGLALLSRPNIASKQWVYRQYDSMVQTNTLTPTGQTDAAVIRIKGTNKGVAMKTDCNARYVYLNPLAGGKIAVAECARNIACTGARPLAITNCLNFGNPLKPEVYFQFKESVRGMGEACRTFNTPVTGGNVSFYNETFIAGQRTAIYPTPMIGMIGLLDNIENLVGSTFTASGDRILLLGNPQLTLDGSEYLVMQYGTPGQDAPAVDLEHEAQLQRLLVALAEQKLLHSAHDVSDGGLLVALAEKAMMNQEMPLSFRVHLSNNDKSETAIQQQLFSEAQGRVVLSAAPEAVAAIMALANDYNLPIQDIGEVVNQQTISLSINEQEVVNLPLSNVAHAYYHALEHALHLDEL
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRNIP_MOUSE
Sequence: MAPAQQSRVLRCCSCHIFQAHQVKKSLKWTCKACGEKQSFVRAYGEGSGADCRRHVQKLNLLQGQVSELSLRSVEEAVNGSEEENAGPLQAEAGSQQAPSKPLESRWLKYLDKGCEDQELDRGRPALKTQLSTSAERPSSPAQPRKRKWNQRTGQPAHSLHGQGVDSVEDNFEHQDSTGLFGTEQQGTSPALSTANHTRELGFPRWKLPSPVTQVNAPSSKWARFLLAPGNSPQVDEKPSPLQEATMLADLAQGTVENKTPVEGHFSRAPAIRPPQAIHTTTPQLDRPDRKTREQPRDMGTPRADGRPLAQGTQKAPPLQLHNLFTTGEDFDDDL
What is the function of this protein?
Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex.  Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair.
What are the official names of this protein?
MRN complex-interacting protein, MRN-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the MRNIP family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Note=Recruited to sites of DNA damage. Phosphorylation induces its nuclear localization and promotes genome stability.
Protein: RL22_NOVAD
Sequence: MSKPKAPRRVGDKEALSVGTQIRGSAQKLNLVAGLIRGKRAEDAMNILAFSKKAMAVDARKVLASAIANAENNHNLDVDALVVAEASVGKSITMKRFHTRGRGKSTRILKPFSRLRIVVREVEEA
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: ATPL_ALIFM
Sequence: METLLSFSAIAVGIIVGLASLGTAIGFALLGGKFLEGAARQPEMAPMLQVKMFIIAGLLDAVPMIGIVIALLFTFANPFVGQLAG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CSPL3_GINBI
Sequence: MDASNPIVHPIGDHHAVDLEEGPLIVTMKELPGMPGTIGGLALRVGQFLFAAAAIVIMVTGDEFTNYTAFCYLVAAMSLQFLWSFMLAILDTYALLIKRGLRNSVLLSLFVVGDWVTATLSLAAACSTAGVTVLFDNDLNYCGQMHCHRYQLSAAMAFLSWLLIGMSSLLTFWLWASE
What are the official names of this protein?
CASP-like protein 5B1, GbCASPL5B1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GGA1_HUMAN
Sequence: MEPAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSWTVGLPEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAGSSEDLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATAGSIPGSTSALLDLSGLDLPPAGTTYPAMPTRPGEQASPEQPSASVSLLDDELMSLGLSDPTPPSGPSLDGTGWNSFQSSDATEPPAPALAQAPSMESRPPAQTSLPASSGLDDLDLLGKTLLQQSLPPESQQVRWEKQQPTPRLTLRDLQNKSSSCSSPSSSATSLLHTVSPEPPRPPQQPVPTELSLASITVPLESIKPSNILPVTVYDQHGFRILFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVKLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLTFTMGDQTYNEMGDVDQFPPPETWGSL
What is the function of this protein?
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes.  Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016).  Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063).  Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity).  Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15886016, PubMed:15615712).
What are the official names of this protein?
ADP-ribosylation factor-binding protein GGA1, Gamma-adaptin-related protein 1, Golgi-localized, gamma ear-containing, ARF-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the GGA protein family.
Protein: ATPE_DESRM
Sequence: MAKTQRLDIVTPEKVVFSEEIDFVVAPGADGELGILPEHAPLVTALKVGTLRVQQGGKFFKVAVSGGFMEVKNSRIVVLADTAERADQIDVERAKAAKQRAEQRLNSKGSEIDVHRAEIALHKAINRIKAAE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NUSG_STRP1
Sequence: MLDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIPTQTVNVEKNGQTKEIEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPTPLLEEEIRAILLSMGQTIDVFDTNIKEGDVVQIIDGAFMGQEGRVVEIENNKVKLMLNMFGSETVAEVELYQIAEL
What is the function of this protein?
Participates in transcription elongation, termination and antitermination.
What are the official names of this protein?
Transcription termination/antitermination protein NusG.
What is the protein family that this protein belongs to?
Belongs to the NusG family.
Protein: NU5M_HYPJE
Sequence: MYLSIIILPLLGSIVSGFFGRKVGVTGSRILGCLSIITTTILAIISFFEVGFNNNPISINLFKWLDSESFNMVWNFQFDSLTVSMLIPVLVISSLVHFYSIGYMSHDPHSQRFFSYLSLFTFMMIILVTGNNYLLMFVGWEGVGVCSYLLVSFWFTRIAANQSSLSAFLTNRVGDCFLTIGMFVILWSLGNLDYSTVFSLAPYINENIITIIGICLLIGAMAKSSQVGLHIWLPMAMEGPTPVSALIHAATMVTAGVYLLIRSSPLIEYSSTVLLICLWLGAVTTVFSSLIGLFQQDIKKIIAYSTMSQLGMMVIAIGLSSYNVAIFHLINHAFYKGLLFLGAGAVIHAVVDNQDLRKYGGLISFLPLTYTVILIASLSLVAFPFMTGFFSKDFILESAYGQYHFSSINVYFIATIGAVFTTLYSVKVIYLTFLANPNGSVNYYKNAHEGDIFLSLPLVILAIFSIYFGYLTKDIYIGLGSGFFIDNSIFIHPMREILIDTEFGVPTIFKLLPFFLTIFFSVLSIVYYEYMPKVVVDFNLTNLGYYIYGFFNQRFLVEFFYNKYIVNTVLDLGGQTTKILDKGSVEWIGPYGFGIALVKASKTVSGLGKGVVTDYALYILIGACFYLSIFTFISIFFDLANSITLSCVLVLLGVNNYVKLNKNDNINENSLTSSFLWSNTKEMSKYTTKIII
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ZNF22_HUMAN
Sequence: MRLAKPKAGISRSSSQGKAYENKRKTGRQRQKWGMTIRFDSSFSRLRRSLDDKPYKCTECEKSFSQSSTLFQHQKIHTGKKSHKCADCGKSFFQSSNLIQHRRIHTGEKPYKCDECGESFKQSSNLIQHQRIHTGEKPYQCDECGRCFSQSSHLIQHQRTHTGEKPYQCSECGKCFSQSSHLRQHMKVHKEEKPRKTRGKNIRVKTHLPSWKAGTGRKSVAGLR
What is the function of this protein?
Binds DNA through the consensus sequence 5'-CAATG-3'.  May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).
What are the official names of this protein?
Zinc finger protein 22, Zinc finger protein KOX15, Zinc finger protein Krox-26.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HUTH_PSEPU
Sequence: MTELTLKPGTLTLAQLRAIHAAPVRLQLDASAAPAIDASVACVEQIIAEDRTAYGINTGFGLLASTRIASHDLENLQRSLVLSHAAGIGAPLDDDLVRLIMVLKINSLSRGFSGIRRKVIDALIALVNAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGEGKARYKGQWLSATEALAVAGLEPLTLAAKEGLALLNGTQASTAYALRGLFYAEDLYAAAIACGGLSVEAVLGSRSPFDARIHEARGQRGQIDTAACFRDLLGDSSEVSLSHKNCDKVQDPYSLRCQPQVMGACLTQLRQAAEVLGIEANAVSDNPLVFAAEGDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISLMMDKHMSQLPPFLVENGGVNSGFMIAQVTAAALASENKALSHPHSVDSLPTSANQEDHVSMAPAAGKRLWEMAENTRGVLAIEWLGACQGLDLRKGLKTSAKLEKARQALRSEVAHYDRDRFFAPDIEKAVELLAKGSLTGLLPAGVLPSL
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2507_LEPCP
Sequence: MRIDFIRQRLRAQGAKPCHEQRILRIWAQVLPTEGGRSRPDDFLPQAVRDAMPALLADLDGLARLRSQHPGEDGSARLLVELADGQTVESVLLPRDGLCVSTQVGCAVGCVFCMTGREGLLRQVGSAEIVAQVVLARRQRLVKKVVFMGMGEPAHNLDNVMEAIDFLGTTGAIGHKNLVFSTVGDPRVFERLPLGPVKPALALSLHTTRADLRAQLLPRAPRMDPADLVERAEAYARATSYPIQYQWTLLEGINDGPDEVEGIVRLLHGKYAVLNMIPYNTVPDLPYTRPSWEAAAALARTLHRRGILTKLRQSAGQDVEGGCGQLRARELAPSARRIEIRPVASLP
What are the official names of this protein?
Probable RNA methyltransferase Lcho_2507.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIG_BARHE
Sequence: MINETRTTLDQSEVDHFSRIAAEWWNPHGKFRPLHQFNPTRLAYIREKICLELHRDPVSLKPFENLKILDIGCGGGLLCEPMARLGAMVVGADASQTNIEVAKIHAAQNGLSIDYRTTTAEALATEGEQFDIILNMEVVEHVADVNLFIEATAKMLKPQGLMFISTLNRTWKAWGLAIIGAEYILRWLPKGTHNYKKFLKPRELKNLLLQNALTVVDEIGVTYNPLNDSWNRSKDMNVNYLLLAKKS
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: GAL1_ACTP7
Sequence: MKPQQLATQKFSEHYGYSAAQTVFAPGRVNIIGEHTDYNDGFVMPCAINYGMAVSFSKRDDSVWRVYAIDIDEQDEFDLSRPIEPSEHKWANYVRGVVKYIQEKCPEFKQGADLAMTSDVPMSSGLSSSAALEISIGKTAQVLGDLPLSLAEIALIGQQAENKFVGANCGNMDQLTSALGQKDQVIMIDCRSLDITPTPVPHGYSIAIINSNVKHDLVTGEYNSRRQECEFAARFFGVKALRDVTSERFIERAAELQAQNELAYKRAKHIISENQRVLEAVEALKANDMVKLGQLMAGSHDSMRDDFEITIPEIDYLVELAQVAIGKNGGARMTGGGFGGCIVCLVPDEKVEHLRRIIADNYEKQTGIKETFHLCTACDGVHLI
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_AFIC5
Sequence: MSRLRTSHALRTAAALVAVGCLASGCSSIERLSQIGEQPKLTAIDNPTTKAGYKPVSMPMPTPQPASYNPNSLWRNGSRAFFKDQRAHQVGDILTVIVNITDKANIANETQRSRANTEDSSITNFFGIKKVPGTNGAGNMLTTGSVASSDGKGSVVRQEALQTNVAAVVTQLLPNGNLVVEGKQEIRVNFEMRELVVAGIVRPEDIQSDNTIDSSKIAQARIAYGGRGQITDVQQPRYGQQVMDILLPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: RF1_YERPB
Sequence: MKSSIVAKLEALQERHEEVLAYLGDASVIADQDRFRALSREYAQLTDVTRCFKEWRSAQDDIEAAEMMLDDLEMREMAQEELKIAKARSEELEQQLQVLLLPKDPDDERDCFLEIRAGTGGDEAAIFAGDMFRMYSRYAETRRWKVEIMSASEGEHGGYKEIIAKISGDGVFGQLKFESGGHRVQRVPETESQGRIHTSACTVAVMPAIPEAELPEINAGDLRIDTFRSSGAGGQHVNTTDSAIRITHIPTGIVVECQDERSQHKNKAKAMSVLGARIRAAEMQKRQLAEASERRNLLGTGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIQPIVQEYQADQLSALSEQD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURQ_METMP
Sequence: MIKVVPKVLVMSGYGINCETETAHAFQKAGAETDIVHINDLIAGKKKMADYEIIMFPGGFSYGDDTGSGNAFANKIKNNLFDDLTEFINSGKLILGICNGFQVMTNLGLFALPSTDYGERISALESNTNNRYECRWVHIKENDSVCVFTKGINVTHVPIAHGEGRFYCDEKTYHELKENKQIVFSYCDSEGNPANGEYPLNPNGAYQDIAGICDKTGRIFGLMPHPERSLYSISEPEYQLKKEIAKRNGDIIPEFIENNLQIFKNAVEYFNK
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBID_MYCTO
Sequence: MSGTPDDGDIGLIIAVKRLAAAKTRLAPVFSAQTRENVVLAMLVDTLTAAAGVGSLRSITVITPDEAAAAAAAGLGADVLADPTPEDDPDPLNTAITAAERVVAEGASNIVVLQGDLPALQTQELAEAISAARHHRRSFVADRLGTGTAVLCAFGTALHPRFGPDSSARHRRSGAVELTGAWPGLRCDVDTPADLTAARQLGVGPATARAVAHR
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
Phosphoenolpyruvate guanylyltransferase, PEP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: KANL2_MOUSE
Sequence: MNRIRIHVLPTNRGRITPVPRSQEPLSCSFTHRPCSQPRLEGQEFCIKHILEDKNAPFKQCSYVSTKNGKRCPSAAPKPEKKDGVSFCAEHARRNALALHAQMKKSNPGPMGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGDQEPITVDQTWRGDPDSEADSIDSDQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHRQLKERRMLATDGAAQQAHTTRSSQRCLAFVDDVRCSNQSLPMTRHCLTHICQDTNQVLFKCCQGSEEVPCNKPVPVSLSEDPCCPLHFQLPPQMYKPEQVLSVPDDLEAGPMDLYLSAAELQPTESLPLEFSDDLDVVGDGMPCPPSPLLFDPSLTLEDHSVTESAGDAGQMQAAGDGCRSQGARSVEKAAFPQRGLATANGKPEPTSIS
What is the function of this protein?
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
What are the official names of this protein?
KAT8 regulatory NSL complex subunit 2, NSL complex protein NSL2, Non-specific lethal 2 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: ADPRH_STRPQ
Sequence: MPSSFDLLGEMIGLLQTEQLTSSWACPLPNALTKRQDLWRALINQRPALPLSKDYLNLEDAYLDDWRASFVPVSVKDCQKTNYTSLFLYHGDIRYLAVDAIVNAANSELLGCFIPNHGCIDNAIHTFAGSRLRLACQAIMTEQGRKEAIGQAKLTSAYHLPASYIIHTVGPRITKGHHVSPIRADLLARCYRSSLDLAVKAGLTSLAFCSISTGEFGFPKKEAAQIAIKTVLKWQAEHPESKTLTIIFNTFTSEDKALYDTYLQKENNCE
What is the function of this protein?
ADP-ribose glycohydrolase that hydrolyzes ADP-ribosyl-cysteine bonds (By similarity).  Specifically reverses the SirTM-mediated mono-ADP-ribosylation of GcvH-L, by releasing ADP-ribose from the target protein.  May be involved in the modulation of the response to host-derived oxidative stress.
What are the official names of this protein?
Protein-ADP-ribose hydrolase, SpyMacroD.
Protein: CASP2_ORYSI
Sequence: MSGSDTSGSVHVDEHGHGKASSSYDGAGAPAPAPAPFQGHRKAGSGSSDVPFLLRSGGSGGDGLRRCLGLIDFVLRVAAFGPTLAAAISIGTSDERLSVFTNYFQFRARFDDFPAFEFFIVANAIAAGYMVLSLPFSAATIMSSKATGVKLLLLICDTIMVGLLTAAASAAAAMVYVAHEGNLRANWVPICLQFHGFCQRTSGAVIASFLAVFVLMVLIVMAAFTMPRRTHHTAS
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 2, OsCASP2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: DTD_AZOPC
Sequence: MRVVIQRVLKASVTINHQLKSSIGQGLLIFLGIEENDKQEDIDFLVKKIVNLRIFNDNKGAMNRSLLDIEGELLCVSQFTLFASTKKGNRPSYIRASKSEKAIPLYEKFCATISSAMSKIIQTGTFKTNMKIKLINDGPVTICIDSKNRE
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_BURCH
Sequence: MKASRFFIGTLKEAPADAEIVSHKLMVRAGMIRRVAGGIYNYLPVGLRSIRKVEAIVREEMNRAGAIELLMPAVQPAELWQESGRWEQYGPELLRFKDRKDNDFVIGPTHEEVVTDIARNQIKSYRQMPVNFYQIQTKFRDEIRPRFGVMRGREFIMKDAYSFDKDAAGLNESYRKMYDAYVRIFTRLGLEFRAVAADSGSIGGNFSHEFHVIADTGEDAIAYCPTSEFAANVEAAEALPLIAERAAPAEAMEKVATPGKAKCEAVAELLSIPLERTIKSIVLATDNEGAEPTIWLVMLRGDHDLNEIKVSKLPGLKNHRFATEQEIVEWFGTPPGYLGPVGTKKPVKVIADRTVANMSDFVVGANEVDYHIAGVNWGRDLPEPEVADVRNVKKGDPSPDGKGVIDICRGIEVGHVFQLGTKYSEAMGATFLDESGKPQPMLMGCYGVGITRILGAAIEQNFDDKGIIWPESIAPFEVVLCPMGYDRSDMVRETADKLYAELVAAGIDVILDDRGERPGVMFADWELIGVPHRLVIGERGLKEGKIEYQGRRDAEATLLPADTAAAAVAEKIRAALAH
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOK_COXB2
Sequence: MIPLGYFLIIGAILFGLGFAGIIINRKNLIVLLMCIELMLLAVNTNFIAFSQYLGARAGEIFVFFILTVAAAESAIGLAILVLFYRRRGSINVDDMNILKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.