PharMolix/UniProtQA huggingface dataset:
Protein: SF3B4_HUMAN
Sequence: MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRGPLPQ
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643).  SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.  Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).  May also be involved in the assembly of the 'E' complex.  SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114).  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077).
What are the official names of this protein?
Splicing factor 3B subunit 4, Pre-mRNA-splicing factor SF3b 49 kDa subunit, Spliceosome-associated protein 49, SAP 49.
What is the protein family that this protein belongs to?
Belongs to the SF3B4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLRX4_HAEIN
Sequence: METLDKIKKQISENPILIYMKGSPKLPSCGFPARASEALMHCKVPFGYVDILQHPDIRAELPTYANWPTFPQLWVEGELIGGCDIILEMYQAGELQTLLAEVAAKHA
What is the function of this protein?
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.
What are the official names of this protein?
Glutaredoxin 4, Grx4, Monothiol glutaredoxin.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family. Monothiol subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_BRASB
Sequence: MFYWLIELTNTFPSLAMFRGLLNVFRYITFRTGGAVVTGALFVFLFGPWIIDHLRLRQGKGQPIRADGPQSHIISKKGTPTMGGLMILSGLVVSTVLWANPLNPYVWIVLAVTLGFGFVGFYDDYLKVTKQSHSGFAGRARILIEAGIALVACYALVRLGRDPSSTGLAIPFFKDLVIKFGWMYVIFGAFVIVGAGNAVNLTDGLDGLAIVPVMIASASFGLIAYLAGNAVFSDYLQIHYVAGTGELAVLCGAVLGAGLGFLWFNAPPASIFMGDTGSLALGGMLGSIAVAVKHEIVLAVIGGLFVLEAVSVIVQVASFKLTGKRIFKMAPIHHHFEQLGWTEPQIVIRFWIISVMLALVGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL2_SALNS
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLVEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKAGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: GRAR_STAAC
Sequence: MQILLVEDDNTLFQELKKELEQWDFNVAGIEDFGKVMDTFESFNPEIVILDVQLPKYDGFYWCRKMREVSNVPILFLSSRDNPMDQVMSMELGADDYMQKPFYTNVLIAKLQAIYRRVYEFTAEEKRTLTWQDAVVDLSKDSIQKGDQTIFLSKTEMIILEILITKKNQIVSRDTIITALWDDEAFVSDNTLTVNVNRLRKKLSEISMDSAIETKVGKGYMAHE
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs) (By similarity) (PubMed:17502406).  Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis.  Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis (By similarity).
What are the official names of this protein?
Response regulator protein GraR, Glycopeptide resistance-associated protein R.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_PSEAE
Sequence: MSNQDSGNPAAKPPKGKTAARRKARSLAVQALYSWQIAGQPLHEIEAQFRTDNDFSEVDGAYFHEILHGVPRQKSELDSTFEPCLDRPLAEIDPVELAILRLSTYELRNRIDVPYKVVINEGIELAKTFGATDGHKFVNGVLDKLAPRLRAAELRGGKR
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: SAT_CATRO
Sequence: MAPQMQILSEELIQPSSPTPQTLKTHKLSHLDQVLLTCHIPIILFYPNQLDSNLDRAQRSENLKRSLSTVLTQFYPLAGRININSSVDCNDSGVPFLEARVHSQLSEAIKNVAIDELNQYLPFQPYPGGEESGLKKDIPLAVKISCFECGGTAIGVCISHKIADALSLATFLNSWTATCQEETDIVQPNFDLGSHHFPPMESIPAPEFLPDENIVMKRFVFDKEKLEALKAQLASSATEVKNSSRVQIVIAVIWKQFIDVTRAKFDTKNKLVAAQAVNLRSRMNPPFPQSAMGNIATMAYAVAEEDKDFSDLVGPLKTSLAKIDDEHVKELQKGVTYLDYEAEPQELFSFSSWCRLGFYDLDFGWGKPVSVCTTTVPMKNLVYLMDTRNEDGMEAWISMAEDEMSMLSSDFLSLLDTDFSN
What is the function of this protein?
Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e. g.  tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine.  Acetyltransferase that catalyzes the formation of O-acetylstemmadenine from stemmadenine.
What are the official names of this protein?
Stemmadenine O-acetyltransferase, CrSAT.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: YL66A_YEAST
Sequence: MMPAKLQLDVLRTLQSSARHGTQTLKNSNFLERFHKDRIVFCLPFFPALFLVPVQKVLQHLCLRFTQVAPYFIIQLFDLPSRHAENLAPLLASCRIQYTNCFSSSSNGQVPSIISLYLRVDLSPFYAKKFQIPYRVPMIWLDVFQVFFVFLVISQHSLHS
What are the official names of this protein?
UPF0479 membrane protein YLL066W-A.
What is the protein family that this protein belongs to?
Belongs to the UPF0479 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RNY_CYTH3
Sequence: MSELIMYILATAVVSIGVGIVAGKAIFQKDFSKQETEAKEKANLIIKEAELKAEATKKDKQLEAKEHFLKLKTEFEEDSNKKKNLIIQNEQKIKQREQTISKQMETNTRREAELDSLRENLSSQLEILNKRKEELEKLRHSQIEKLEKIAGLTGEEAKAQLMDTIKEEARTEASSYIKRITDEAKMTATKDAKKIVIETLQRTATENAVENCVSIFNIESDDIKGKIIGREGRNIRALEAATGVEIIVDDTPEAIIISGFDPVRREVARLSLHRLVQDGRIHPARIEEVVTKTAKHLDEEIIEIGERTAIDLGIHGLHPELIRLVGRMRFRSSYGQNLLQHSREVAKLCATMASELGLNAKVAKRAGLLHDIGKVYPDEPELPHAILGMELAKKYKESAEICNAIGAHHDEIEMTGLISPIVQVCDAISGARPGARREVMEQYIKRLKDLEQLALSFDGVLKCYAIQAGRELRIMVDAENVSDDKAGILSFDIAQKIEKEMQYPGQIKVTVIREMRAVNFAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: COX6_YEAST
Sequence: MLSRAIFRNPVINRTLLRARPGAYHATRLTKNTFIQSRKYSDAHDEETFEEFTARYEKEFDEAYDLFEVQRVLNNCFSYDLVPAPAVIEKALRAARRVNDLPTAIRVFEALKYKVENEDQYKAYLDELKDVRQELGVPLKEELFPSSS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable).  COX6 may stabilize the region of CIV at the interface with CIII, supporting a role in formation or stability of the CIII(2)IV(2) SC (PubMed:30598554).
What are the official names of this protein?
Cytochrome c oxidase subunit 6, mitochondrial, Cytochrome c oxidase polypeptide VI.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5A family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: YBEY_NITEU
Sequence: MPTRNMPLTKNPVESPDHEQELVLTVQYVADKTDIPNRRLFRKWVKAALSKPAEVVIRIVDRQEGEILNRDFRGKSSATNVLTFVYDDDVPLLGDIVLCAPVICNEAQQQGKDLTAHYAHLTIHGILHLQGYDHIRDEDAVVMESLETEIITRLGYPDPYVIQH
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_WOLPP
Sequence: MLMVPNIAILSGGFSCEREISLMSGKAVKKALDSLSYNAIEIDVDSNIAQKLKKTNPALAFIALHGPYGEDGCIQGLLEILGIKYTHSEVMASAVAMNKVMSKHIFHSLNIDTPRGYVISREDVLKNNIKVDYPYVLKPINEGSSIGVHMIFSHEDYLELKNNSSTIMEKMIIEEYIPGIELHTAVLLNEAIGTMEIRPKNKFYDYEAKYTDGFAEHIFPAEIPNNIYRITLEHALKVHQFLGCKTVSRSDFRYNPQNNTLKMLEVNTHPGFTELSLVPEIAKLTRGIDFNELVKIIVEDSLHHRNIRDQADVEQCY
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNG_ECO57
Sequence: MTAELLVNVTPSETRVAYIDGGILQEIHIEREARRGIVGNIYKGRVSRVLPGMQAAFVDIGLDKAAFLHASDIMPHTECVAGEEQKQFTVRDISELVRQGQDLMVQVVKDPLGTKGARLTTDITLPSRYLVFMPGASHVGVSQRIESESERERLKKVVAEYCDEQGGFIIRTAAEGVGEAELASDAAYLKRVWTKVMERKKRPQTRYQLYGELALAQRVLRDFADAELDRIRVDSRLTYEALLEFTSEYIPEMTSKLEHYTGRQPIFDLFDVENEIQRALERKVELKSGGYLIIDQTEAMTTVDINTGAFVGHRNLDDTIFNTNIEATQAIARQLRLRNLGGIIIIDFIDMNNEDHRRRVLHSLEQALSKDRVKTSVNGFSALGLVEMTRKRTRESIEHVLCNECPTCHGRGTVKTVETVCYEIMREIVRVHHAYDSDRFLVYASPAVAEALKGEESHSLAEVEIFVGKQVKVQIEPLYNQEQFDVVMM
What is the function of this protein?
An endonuclease that acts in the processing of the 5'-end of 16S rRNA and 23S rRNA.  It prefers 5'-monophosphorylated substrates and cleaves single-stranded sites rich in A and U residues; contributes to tRNA processing and mRNA turnover.
What are the official names of this protein?
Ribonuclease G, RNase G.
What is the protein family that this protein belongs to?
Belongs to the RNase E/G family. RNase G subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_SYNWW
Sequence: MNFQELILRLHNFWGQQGCIIQQPYDVEKGAGTMNPATFLRALGPEPWKVAYVEPSRRPTDGRYGENPNRLQHYYQYQVILKPSPDNVIDLYLASLRDLGIEPEKHDIRLVEDNWESPTLGAWGLGWEIWLDGMEITQFTYFQQCGGFDCLPVSAEITYGIERIAMYIQNKESVFDIEWVDGISYADVHHQAEVDYSHYNFEAADVGALTSMFNICEEEAIRVAERQLVQPAYDYVLKCSHLFNLLDARGAISVTERTAYIGRVRNLARMVAREYLEQRKRLNYPLLKDEKLRKQLIIEEEVL
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_CHLPM
Sequence: MLTLLAILTVSYIIGSIPTSIMAGKMMKGIDIRNFGSGNAGGTNAFRVLGWKTGLTVTLIDIVKGVVAAVSVVAFFRHHPIGAFPDINEVALRLLAGMSAVIGHVFTVFAGFKGGKGVSTAAGMLIGIAPVSMLMVIGIFLLTVWFSRYVSVASIFAAVAFPLIIAIRKYVFELGGGLDYYIRLFGESFSFHDSLDYHLIIFGLLVAFAILFTHRANIRRLISGTENRVTFRKHA
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EP84_HCMVA
Sequence: MDLPTTVVRKYWTFANPNRILHQSVNQTFDVRQFVFDTARLVNCVDGDGKVLHLNKGWLCATIMQHGEASAGAKTQQGFMSIDITGDGELQEHLFVRGGIVFNKSVSSVVGSSGPNESALLTMISENGNLQVTYVRHYLKNHGESSSGGGGCGAASTASAVCVSSLGGSGGTRDGPSAEEQQRRRQEQRHEERRKKSSSSAGGGGGGGAGGGGGGGGSGGQHSSDSANGLLRDPRLMNRQKERRPPPSSENDGSPPLREAKRQKTTAQHEGHGGGGKNETEQQSGGAGGGGGGGSGRMSLPLDTSEAVAFLNYSSSSSAVSSSSNNHHHHHHHHNAVTDVAAGTDGALLLPIERGAVVSSPSSTSPSSLLSLPRPSSAHSAGETVQESEAAATAAAAGLMMMRRMRRAPAEAAEAPPQSEEENDSTTPVSNCRVPPNSQESAAPQPPRSPRFDDIIQSLTKMLNDCKEKRLCDLPLVSSRLLPETSGGTVVVNHSSVARTAAAVSAAGVGPPAAACPPLVTTGVVPSGSVAGVAPVAAAIETPAAPPRPVCEIKPYVVNPVVATAAAASNSSSSSSAPLPPPPPPSGGRRGRARNNTRGGGGGGGGRNSRRQAASSSSSSSRRSRRRNNRHEDEEDNDPLLRLSQVAGNGRRRGPSFLEDGLEIIDPSEEAAIAAASIAAFFDD
What is the function of this protein?
Promotes efficient viral DNA replication.  Recruits the DNA polymerase processivity factor to pre-replication foci.
What are the official names of this protein?
Early phosphoprotein p84.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae U79/UL112 family.
What are the subcellular locations of this protein?
Host nucleus. Virion. Note=Found in subnuclear structures known as promyelocytic leukemia oncogenic domains (PODs) or nuclear domain 10 (ND10) during the early stages of viral infection (PubMed:16501081). SUBCELLULAR LOCATION: [p20]: Virion. SUBCELLULAR LOCATION: [p26]: Virion. SUBCELLULAR LOCATION: [p28]: Virion.
Protein: CYC21_RHOCE
Sequence: QDGDPVKGEAVFKKCMACHRIGPDAKNLVGPVLTGVVGRQAGVAPGFSYSALNHAAGEAGLHWTAENIMAYLPDPNAFLRKFVTDAGNPEAAKGSTKMVFKLPNEQERKDVVAYLKTFSN
What is the function of this protein?
Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway.  However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.
What are the official names of this protein?
Cytochrome c2 iso-1, Cytochrome c552.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
Protein: GPX3_PONPY
Sequence: MARLLQASCLLSLLLAGFVPQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK
What is the function of this protein?
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
What are the official names of this protein?
Glutathione peroxidase 3, GPx-3, GSHPx-3, Plasma glutathione peroxidase, GPx-P, GSHPx-P.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: CSPL2_OSMLA
Sequence: MVLRIVASLLSIAALVLMAKDKQVVYLNLAGEELTLEAKHSYVEAFVYLVYSNGLVAIYCFLLVFALVFRLIDKAGCGKSAAWIIFLLDQGLAYVLLAAAAASTEVAYVAKRGNNKVGWSEVCSTFGHFCNLVGVSIVITFISVLAMATLSVMSARRLFKTYGPERKQISSNDAPAI
What are the official names of this protein?
CASP-like protein 2U1, OlCASPL2U1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1068_POLNS
Sequence: MLIVLSPAKSLDYKTPFKVKAPTLPEFVSESAKLITDLKKLAPQDVAKLMGLSDQLAALNVGRYRDWSKKFTEENSKPAIYAFDGDVYDGFDVKTLKPKAVEFAQDHIRILSGLYGVLKPLDLMQPYRLEMGTSFKNARGKDLYAFWGNRVTDSLKKALDKQKNPVLLNLASEEYFKVLQPKELDCPVISPVFQDAKDGKYKIISFYAKRARGLMARYVVENRITDPVDLKGFSLDDYKYYAAESKIDKPVFRRVERK
What are the official names of this protein?
UPF0246 protein Pnec_1068.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: FOLD_SHEHH
Sequence: MTAQIIDGKAIAQTIRTQLKDKVTARKEAGQRAPGLAVILVGADPASQVYVGSKRRACEEVGFISRSYDLDSSTSEEALLSLIDECNEDPSIDGILVQLPLPEHIEESKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRACTPMGIMTLIKSTGVDTFGLDAVVIGASNIVGRPMALELLLTGCTTTICHRFTRNLEDKVRQADLLVVAVGKPGFIPGDWIKPGAIVIDVGINRLEGGQLVGDVQFDDAAQHASFITPVPGGVGPMTIASLLENTLYACEQYHD
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PPHLN_HUMAN
Sequence: MWSEGRYEYERIPRERAPPRSHPSDGYNRLVNIVPKKPPLLDRPGEGSYNRYYSHVDYRDYDEGRSFSHDRRSGPPHRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVRNTEMDHDGTPENEGEETAQSAPQPPQAPQPLQPRKKRVRRTTQLRRTTGAPDITWGMLKKTTQEAERILLRTQTPFTPENLFLAMLSVVHCNSRKDVKPENKQ
What is the function of this protein?
Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression.  The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3.  In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416).  Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697).  The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602).  May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457).
What are the official names of this protein?
Periphilin-1, CDC7 expression repressor, CR, Gastric cancer antigen Ga50.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions (PubMed:12853457). Localizes to chromatin (PubMed:26022416).
Protein: FHL17_HUMAN
Sequence: MATAQPSQVRQKYDTNCDAAINSHITLELYTSYLYLSMAFYFNRDDVALENFFRYFLRLSDDKMEHAQKLMRLQNLRGGHICLHDIRKPECQGWESGLVAMESAFHLEKNVNQSLLDLYQLAVEKGDPQLCHFLESHYLHEQVKTIKELGGYVSNLRKICSPEAGLAEYLFDKLTLGGRVKET
What are the official names of this protein?
Ferritin heavy polypeptide-like 17, Cancer/testis antigen 38, CT38.
What is the protein family that this protein belongs to?
Belongs to the ferritin family.
Protein: BIOB_HELPS
Sequence: MQEIFLCSISNVRSGDCKEDCAYCTQSSHHQGAIKRYKFKDEKVVLQEARALRELGALGFCLVTSGRELDDEKCEYIAKLAKAINQEELGLHLIACCGRADLEQLEFLRDAGIHSYNHNLETSQNFFPKICSTHTWEERFITCENALRAGLGLCSGGIFGLNESWEDRIEMLRALASLSPHTTPINFFIKNPVLPIDTETLSADEALECVLLAKEFLPNARLMVAGGREVVFKDNDKKEAKLFEYGINAVVLGDYLTTKGKAPKKDIEKLLSYGLTMATSCH
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: GPDA_BLOPB
Sequence: MSIKYPKYPNITIIGAGSYGTAIAIALSRNGHSVLLWGHNAIHIQKLQINRCNQAYLPGIAFPPSLYLEKSLSIALSTCRNLLIAVPSRVFGHVLMRLKPNLKSNTRIIIASKGLEPKTGRLLQDVAYDILGKNIPIAIISGPTFARELAMGLPTAITLASNDTILSCDLQNILHCNKNFRIYSNTDTIGIQIAGVVKNIIAIGAGISDGIGFGSNARTALITRGLVEMSRLGIAIGATLDTFMGLAGLGDLILTCTDNQSRNRRFGILLGQGFEIHHAQKNVGKIIEGFYNIKEVYMLSVKHKVDMPITEQTYQILYQNKNVHDAAHSLLERTQKEEKINGLK
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_STUS1
Sequence: MKANELREKSVEQLNEQLLELLRDQFNLRMQKATGQLGQSHLLSQVKRDIARVKTVLNQQAGK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: RL34_THEKO
Sequence: MKPMYRSRSWRRKYVRTPGGRTVIHFERRKPKVAHCAMCGRPLNGVPRGRPSELRKLPKTKKRPERPYPNLCPSCMRKVMKAQVRASITA
What are the official names of this protein?
50S ribosomal protein L34e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL34 family.