PharMolix/UniProtQA huggingface dataset:
Protein: RPOC_FRATO
Sequence: MNNGILHQNYNSKKFDIIKISLASPEVIRSWSHGEVKKPETINYRTFKPERDGLFCAKIFGPIKDYECLCGKYKRLKHRGVVCERCGVEVEQAKVRRERMGHIDLVCPVVHIWYLKSLPSRIGLFLDMPLKNVEKVLYFESYIVTDPGMTPLEKKQLLTDEEYAEALENYGYEFEASMGAEAIRDLLADTDIESEIELLQAECEESKSTAKKEKAIKRLRLLETFQASGNKPEWMVMTVLPVLPPDLRPLVPIEGGRFATSDLNDLYRRVINRNNRLKKLLDLNAPDIIVRNEKRMLQEAVDALLDNGRRGRAVTGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPSLRLHECGLPKKMALELFKPFVYSKLRLGGHATTIKQAKRMVELEEAVVWDILETVINEHPVLLNRAPTLHRLGIQAFEPRLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLTVESQLEARVLMMSTNNILSPASGQPIITPTQDIVLGLYYITREKEGARGEGKLFSSYEDVSRAYNSGTIDIHAKIKLRIDRQVFDTKGNTYNEKGVVNTTVGRALLLNILPEGLSFSLLNKVLVKKEISKIINQAFRVLGGKATVVLADKLMYAGFKYSTLSGVSVGVDDMTIPDNKEAKIEEAEKEIKQITEQYQSSLITENERYNNIINIWSKTSDEVGASMMDAISKDTVSINGEKKEIESFNSVYMMAKSGARGSYNQMRQLAGMRGLMAKPDGTMIETAITANFREGLSVLQYFTSTHGARKGLADTALKTANAGYLTRRLVDVAQDLVVIEEDCGTDDGLMFSAIVEDGEVKVPLVERALGRTLAADVVTEKGVVLLEAGTLLDENLVELLDDNGIDMIKVRSPITCKTRRGLCAKCYGRDLARERQVNVGESVGVIAAQSIGEPGTQLTMRTFHTGGAASLGITVSDIKVKTAGKIKFKNIRTVTNKEGQEIVISRAGEIIVSDTMGRVREQHKIPMGAVVPLASGKAVEIGDVIATWDPHAQPLITDVAGKVVLEDVIDGITSKHTYDDLTGQQTIEITSISQRTTSKNLKPVVKIVDEKGAELKSIPLAVGAVLNVADDSILEVGDIVAKIPLEGSKNKDITGGLPRVAELFEARRPKDAAILSPCDGMVRLGNRDTKEKQRIEIIDKNGHIVEEILLPKSRHLVVFDGEQVSRGDVLADGPTDPHDLLKYKGLEEFADYILIEAQSVYRMQGVVINDKHIETIVRQMLRKAVILDEGDSKFVKDESIELVRILEENDKLRKQGKKEVEYELVLMGITRSSLSTESFLSAASFQETTRVLTEASINSQIDNLRGLKENVLIGRLIPAGTGLAVRKESAKIEKMREELGVEDNMVFTDLSSFNPEEISFDSIQSQKEDKDINEDIEESLRNALESLDF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: ELAV3_MOUSE
Sequence: MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILLDQATGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA
What is the function of this protein?
RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10734193, PubMed:9016658).  May also bind poly-A tracts via RRM 3 (PubMed:9016658).  May be involved in neuronal differentiation and maintenance (PubMed:9016658).  Plays a role in the stabilization of GAP43 mRNA and in spatial learning (PubMed:11573004).
What are the official names of this protein?
ELAV-like protein 3, Hu-antigen C, HuC.
What is the protein family that this protein belongs to?
Belongs to the RRM elav family.
Protein: LPXK_BARHE
Sequence: MHLSAPHFWWKNKSFLRFLLAPISWGYAYFSRRRMARHPPIVDLPVLCIGNFTCGGAGKTPVVIAFAKVAKELGFVPGVVSRGYGGRVKGIHLVNEEHDNAYDVGDEALLLARHAFVAISVDRYAAAQRLKKEGCNLILMDDGFQSRRLYMDYALLVVDAMRGFGNGAVFPAGPLRVPLKTQFSLMDSVLLIGDSDACDYIAFLVNRTGKSLHHAHLESLASDKVAGKSFLAFAGIGNPDKFLKSIKELSGHVVQTYFYPDHYFFTNTDLKNLVQRAKMHNLWLATTAKDYIRIQTSKMQEDLKNLVVFDINVNFVQKNFCRVLLQEVMIRFRERKHSL
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: NFRA_STAA3
Sequence: MSEHVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKENLREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAENIAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPFDHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDMLEQLQKSGLIQR
What is the function of this protein?
Reduces FMN, organic nitro compounds and disulfide DTNB.  Involved in maintenance of the cellular redox state and the disulfide stress response (By similarity).
What are the official names of this protein?
NADPH-dependent oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the flavin oxidoreductase frp family.
Protein: TNNT2_SHEEP
Sequence: MSDVEETVDEYEEQEEAAVEEHEESVEEEAGGEARQGGGASAAEDGEEEEGREAEDGPVEESKPQAPGPFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQTLIEAHFENRKKEEEELVSLKDRIEKRRAERAEQQRIRTEREKERQARLAEERARREEEESRRKAEDEARKKKALSNMMHFGGYIQKAQAERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKARELWQSIYDLEAEKFDLQEKFKQQKYEINVLRNRVNDNQKVSKTRGKAKVTGRWK
What is the function of this protein?
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
What are the official names of this protein?
Troponin T, cardiac muscle, TnTc, Cardiac muscle troponin T, cTnT.
What is the protein family that this protein belongs to?
Belongs to the troponin T family.
Protein: LPQB_NOCFA
Sequence: MTMRAARLSGSTGLTAALVAVLLVLTGCASLPESSAPQALGTIDREPTSEGPTPPIAGRDPDLLLRDFLQATADPTNRHLAARQYMTPAASAQWDDSTSTTIVEKPDTLLESRDGDRATYRIRAQRMAELSADGAYRAVNEPTLENKIEMVKVDGEWRIAELPDGVVMDITAFTKSYRRYVLYFADPSGNTAVPDLRWLSVPKNQLTQRLLSLLSEGPHGAIGAVVRNQLAAPVALRGPITKANGDPDDVGVGLGGVRLDFAGAAALSQRDKELLAGQVVLTLAQADIPGPYMLLADGRPLDERYATNGWSAADVEYLSPSVQAQNRIGLHALRDGALTQVTDNGVVETPGYFGSVNNLQSAALSPDGQLVAAVADAGRPAPEPPRTLMVGTYGGPAFPVAEGGSITRPSWTGDGSAAWAVIDGDRVIRAVNDRATGTVSVQGVDISGLTADPAGPALRLPITELRISRTGVRAALIADGKVYVAVVERRPDGGYALTAPVPVAVGLSTKATSLSWIGGDTLLIAREGNIDPVSTVLIDGSEWTPVTSQNLTPPVRVITAAPGAQYVADSRGVLELTSNTTSELHYWTEMPGLVGTDAAPVLPG
What are the official names of this protein?
Lipoprotein LpqB.
What is the protein family that this protein belongs to?
Belongs to the LpqB lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ISPF_MYCBO
Sequence: MNQLPRVGLGTDVHPIEPGRPCWLVGLLFPSADGCAGHSDGDVAVHALCDAVLSAAGLGDIGEVFGVDDPRWQGVSGADMLRHVVVLITQHGYRVGNAVVQVIGNRPKIGWRRLEAQAVLSRLLNAPVSVSATTTDGLGLTGRGEGLAAIATALVVSLR
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: FIMF_SALTY
Sequence: MILRRVFIAIGCVLFSPLSQANSSLGEVNIELRGNVVDFTCAVVAGDSNKSVNLGTWPTKQLHAAGDATQPVAFSLKLEGCPPGSASITFSGTPAPGTALLALADTAMAQKLAIEIRDGDQRRLPLEQASKAVDIDNNGNATLKFYANYIALADGVQPGLANADATFLINYN
What are the official names of this protein?
Fimbrial-like protein FimF.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: LOLD_SODGM
Sequence: MNETPLLHCSRLSKRYQEGKLYTYVLRNVSFMLERGEMMAIVGSSGSGKSTLLHLLGGLDEPTGGEVIFEGQQLNKLSSAARAMVRNRRLGFIYQFHHLLPDFTALENVAMPLLIGGARPAQAQETAREMLAAVGLEKRGHHRPAELSGGERQRVAIARALVNHPALVLADEPTGNLDQRNADSIFELLGELNMRQGTAFLVVTHDLQLAKRLHRQLEMRDGALLGAAQ
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CX5B2_ARATH
Sequence: MWRRIVSSHLKSISAVGSCAAPSCRHAVVESTHLSLSTRASSIPAYSSIFSRLIGSAAADTAVKKRVEDVMPIATGHEKEELQAELEGRKLDDIDFPEGPFGTKEAPAVVKSYYDMRIVGCPGGEGEDEHDVVWFWLEKGKSFECPVCTQYFKLEVVGPGGPPDGHGDDHH
What is the function of this protein?
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
What are the official names of this protein?
Cytochrome c oxidase subunit 5b-2, mitochondrial, AtCOX5b-2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5B (TC 3.D.4.11) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: CYSG_PSEA7
Sequence: MDFLPLFHSLQGRLALVVGGGEVALRKARLLADAGARLRVVAPQIHIELRHLVEQGGGELLERDYQDGDQPGCALIIAATDDEPLNAEVSRAANARGIPVNVVDAPALCSVIFPAIVDRSPLVVAVSSGGDAPVLARLIRAKLETWIPSSYGQLAGLASRFRNRVKELLPDLQQRRVFWENLFQGEIAERVLAGRPAEAERLLEERLAGGLAHMATGEVYLVGAGPGDPDLLTFRALRLMQQADVVLYDRLVAPAILELCRRDAERLYVGKRRAEHAVPQERINRLLVELASQGKRVLRLKGGDPFIFGRGGEEIDELAAHGIPFQVVPGITAASGCAAYAGIPLTHRDHAQSVRFVTGHLKDGTTDLPWKDLVAPGQTLVFYMGLVGLPVICEQLVAHGRSAQTPAALIQQGTTAQQRVFSGTLENLPQLVAEHEVHAPTLVIVGEVVQLRDKLAWFEGAREGA
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: MS18A_MOUSE
Sequence: MSSESPLLEKRLSEDSSRYLRLQKWANMSSADALGLEKERPEEKAAAAENPLVFLCARCRRPLGDSLTWVASQEDTNCILLRSVSCNVSVDKEPKLSKCRDEDGCILEALYCTGCSLSLGYVYRCTPKNLDYKRDLFCLSVEAVESYTLGSSEKQIVSEDKELFNLESRVEIEKSIKQMEEVLTALQKKLREVESKLSLASRGS
What is the function of this protein?
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
What are the official names of this protein?
Protein Mis18-alpha.
What is the protein family that this protein belongs to?
Belongs to the mis18 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
Protein: PSTB1_PSEPK
Sequence: MRKGASNLNVSTAQRAAPMVSEAPIVMDCKLDKIFYGNFMAVRDSHVPIRKNEITGFIGPSGCGKSTVLRSLNRMNDLVKGFRFEGHVHFLGQDVYGKGVDPVVVRRYIGMVFQQPNPFSMSIFDNVAFGLRLNRYKGDLGDRVKHALQGAALWDEVKDKLKVSGLSLSGGQQQRLCIARAIATEPEVLLLDEPCSALDPIATRRVEELMVELKKDYTIALVTHNMQQAIRVADTTAFFSVDISQGTRTGYLVEMGPTAQIFQNPREQLTSDYISGKFS
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MEP3_ARTOC
Sequence: MHGLLLAGLLALPMNVLAHPAEQQTSSVLSRRGVDIDSFRLPLKAKYMDSDATAQKIQALSFSKEDDYVSTATKLVKSTFPKSTFRVVDDHYIGTNGIGHVHFKQTAHGLDIDNSDFNVNIDRDGKVFSFGNSFFTGEIPKESPMVKREFSDPVKALKGAVKALNLPVKSENAKAKTVEGKESFEFQGTSGALSAPKAKLVYLQKEDGSLALTWKVETDVGDNWLLSYVDAHDSETVHNVVDYVASAEFKVFAWGLNDPTEGNPTSFRDPWTASSPFTWHSDGTNKYPTTRGNNAIAQDNPTGGSTYLNNYRPQSANLIFNYPWTAAMTPPSSYKDFSITQLFYTTNRYHDLLYSFGFNEAAGNFQVNNNNKGGKGNDFAIVNAQDGSGTNNANFATPPDGSPGRMRMYNWTTARPNRDGCLEAGIVIHEYTHGLSNRLCGGPANSACLNALESGGMGEGWGDFYATAIRLKPRDTKNTNYSMGAWAANDPKGIRAYLYSTNLQTNPYMYTSVNNLREVHGIGTVWATMLYELMWGLIEAHGGTYSADPVFRNGVPQDGRHLAMKIVMDGMALQPCNPNFVQARDAIIDADRALTNGANKCTIWKAFAKRGLGYGAKYDPRTRTGSNQLPPGC
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 3, Fungalysin MEP3.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPRT_ECOLU
Sequence: MKTSRLPIAIQQAVMRRLREKLAQANLKLGRNYPEPKLSYTQRGTSAGTAWLESYEIRLNPVLLLENSEAFIEEVVPHELAHLLVWKHFGRVAPHGKEWKWMMESVLGVPARRTHQFELQSVRRNTFPYRCKCQEHQLTVRRHNRVVRGEAVYRCVHCGEQLVAK
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMUV_PLESH
Sequence: MRNLTLQRGRRQILSQLSLDLRAGELTVLLGPNGTGKSTLLKCISGEMAAQGEIRLFGQPQSQWPAPILARRMAILPQSSALSFSFLAREVVALGRLPHASGKIADEVIIQRCLQAVGAEHLADSAYTVLSGGEKQRIHFARVLAQLDEHMVDSPQTEREPTAAAPKLLMLDEPTSALDLSHQHQTLQTAQRRARQGDAVLVILHDLNLAARYADRILLLNHGQIQADGSPEEVLTAERIKQIFAFDAQVFRHPETGRLHIS
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PAND_CALS8
Sequence: MLIEVLKSKIHRATVTEANLNYVGSITIDEELMEAAGILENEKVQVVNINNGERFETYVIKGERGSGTICLNGAAARLVQVGDKVIIMAYCLLTMEEYKTHMPKIVFVDDNNKIVKLSNKEEHSECLC
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COTJC_BACSU
Sequence: MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLNQRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSALFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRFLREREIVHSMRFREAVEILKEERDKKKIF
What is the function of this protein?
The cotJ operon proteins affect spore coat composition.  They are either required for the normal formation of the inner layers of the coat or are themselves structural components of the coat.
What are the official names of this protein?
Protein CotJC.
What is the protein family that this protein belongs to?
Belongs to the manganese catalase family.
Protein: C25HL_CAEEL
Sequence: MLDLYPVQNLTVDQLEYEKNTRFLQPAWDWIKNGNEHILSSPLFPPFYALSIDYTWVAVFTFIDVFLCNVPFFKDAKIQKDRKVTWDLIKKSLKLQGWNQLLWIYPMALVQLIWVPDTELPILAPTVFEMLSQLAIFFLAFDFTYFWFHYINHKVKWLYRWCHSVHHMYSSPFAASAQHLHPFELFFVGTFITTIPWIFPTHCLTYWIWFFIAQSVSYEVHIGYDFPFALHRIFWFYSGAPAHDMHHLRPLTCFQPWFNYLDRLMGYHITYADLKKMTEAKFKKFGLYSAEDEKGLIKIN
What is the function of this protein?
Probable sterol desaturase.
What are the official names of this protein?
Cholesterol 25-hydroxylase-like protein.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PTOV1_BOVIN
Sequence: MVRPRRAPHRSGAGGPLGGRGRPLRPFTARAARSRSWPASPRGPQPPRIRARSAPPMQGARVFGALGPIGPSSPGLALGGLAVGEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRALPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRVMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNAIRQVITTRKQAVGPGGVAGPVQIVNNKFLAWSGVMEWQEPRPEPHSRSKRWLPSHIYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCEVRVLMLLYSSEKKIFIGLIPHDQSNFVNGIRRVIANQQQVLQRNLEQEQQQRGMGG
What is the function of this protein?
May activate transcription.  Required for nuclear translocation of FLOT1.  Promotes cell proliferation.
What are the official names of this protein?
Prostate tumor-overexpressed gene 1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane. Cytoplasm, perinuclear region. Note=Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts.
Protein: ROQR_PENRW
Sequence: MSGYVLLTVQLAAVLLLVTLWRAFRPNTRSNRVVSYIINVGNTPKIHQKNKADFHPRTNVEISPLVVPNLFDRWLNAHSDLPLSISRWRGKYQVPGGGERLPILTGADEIKAVFKDSGNHRKASNLNGGWVMGDLVGDGVGLISEGHWKRVHAVVSPPFTQKPTTYVPFVQSRISRHFSELYPEDEGGRTLRIKPAEDLKLLPFWVISDLLYGNLSPEMTEELLQITDLRTDVFRYAFKGGLSLFSISKIFYPDIRNKLHVFHTRWANFNRKAYQCALNRDDASACAIVTLYRAVEQGQITPTELMHTLDEALFANIDVTIGSFSWIPQFLAEDAALQSKLRKEISHARSDTAPESWVKYIGSNSTLLASCINESARLKPVTNYTYAQSMPTDRDVGGYRIPRGTFMVVDTNALNIWDDAWGSDKTSYRPQRFLEESRASFRYRFWRFGFGPRQCIAQALADTILKVLVAYTVENYELKSTGKSAANEEDAHKQGEAWFKVAEQGIILEAL
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the mycotoxins roquefortine C and meleagrin (PubMed:22118684, PubMed:23776469).  The first stage is catalyzed by the dipeptide synthase roqA which condenses histidine and tryptophan to produce histidyltryptophanyldiketopiperazine (HTD) (PubMed:22118684, PubMed:23776469).  HTD is then converted to roquefortine C through two possible pathways (PubMed:23776469).  In the first pathway, prenyltransferase roqD transforms HTD to the intermediate roquefortine D, which is in turn converted to roquefortine C by the cytochrome P450 monooxygenase roqR (PubMed:23776469).  In the second pathway, HTD is first converted to the intermediate dehydrohistidyltryptophanyldi-ketopiperazine (DHTD) by roqR which is then prenylated by roqD to form roquefortine C (PubMed:23776469).  Roquefortine C can be further transformed to meleagrin via three more reactions including oxydation to glandicolin A by roqM, which is further reduced to glandicoline B by roqO (PubMed:23776469).  Finally, glandicoline B is converted to meleagrin by the glandicoline B O-methyltransferase roqN (PubMed:22118684, PubMed:23776469).  More studies identified further branching and additional metabolites produced by the roquefortine/meleagrin cluster, including roquefortine F, roquefortine L, roquefortine M, roquefortine N and neoxaline (PubMed:24225953).
What are the official names of this protein?
Cytochrome P450 monooxygenase roqR, Roquefortine/meleagrin synthesis protein R.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: DHX9_HUMAN
Sequence: MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGPETRLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIKLQISHEAAACITGLRAAMEALVVEVTKQPAIISQLDPVNERMLNMIRQISRPSAAGINLMIGSTRYGDGPRPPKMARYDNGSGYRRGGSSYSGGGYGGGYSSGGYGSGGYGGSANSFRAGYGAGVGGGYRGVSRGGFRGNSGGDYRGPSGGYRGSGGFQRGGGRGAYGTGYFGQGRGGGGY
What is the function of this protein?
(Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641).  Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208).  Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:9892698, PubMed:11096080).  Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208).  Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162).  Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641).  Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149).  Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886).
What are the official names of this protein?
ATP-dependent RNA helicase A, DEAH box protein 9, DExH-box helicase 9, Leukophysin, LKP, Nuclear DNA helicase II, NDH II, RNA helicase A.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
Protein: TRAF6_PIG
Sequence: MSLLHCENSCGSSQSESDCCAAMAASSCGAAAKDDGVSGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLTVKCPNVGCLHKMELRHLEDHQAHCEFALMNCPQCQRPFQKCQLNIHILKECPRRQVSCVNCAVSMAFEDKEIHDQNCPLANVICEYCNTVLIREQMPNHYDLDCPTAPVPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMMAQALQGLSLAVAPVPQRDMLPYDSSPLSRISSGCCSDQNFQETIQQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRSLEDKVAEIEAQQCNGIYIWKIGNFGMHLKSQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPIRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLDALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDSGT
What is the function of this protein?
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2.  Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.  Leads to the activation of NF-kappa-B and JUN (By similarity).  Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity).  Represses c-Myb-mediated transactivation, in B-lymphocytes.  Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity).  Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.  Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity).  Participates also in the TCR signaling by ubiquitinating LAT (By similarity).
What are the official names of this protein?
TNF receptor-associated factor 6, E3 ubiquitin-protein ligase TRAF6, RING-type E3 ubiquitin transferase TRAF6.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family. A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet. Note=RSAD2/viperin recruits it to the lipid droplet.