PharMolix/UniProtQA huggingface dataset:
Protein: HEM62_ARATH
Sequence: MASHSSTLFTSPSSFILFSSHRLKSSPNYFTYHFPRSVKRPHFDLRCSVSIEKEVPETERPFTFLRVSDGDQTQSSSYSVRARFEKMIRTAQDKVCEAIEAVEEGPKFKEDVWSRPGGGGGISRILQDGNVWEKAGVNVSVIYGVMPPEAYRAAKAATSEQKPGPIPFFAAGTSSVLHPQNPFAPTLHFNYRYFETDAPKDVPGAPRQWWFGGGTDFTPAYIFEEDVKHFHSV
What is the function of this protein?
Key enzyme in heme biosynthesis.  Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity).
What are the official names of this protein?
Coproporphyrinogen-III oxidase 2, chloroplastic, AtCPO-II, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LPXA_HELPG
Sequence: MSKIAKTAIISPKAEINKGVEIGEFCVIGDGVKLDEGVKLHNNVTLQGHTFIGKNTEIFPFAVLGTQPQDLKYKGEYSELIVGEDNLIREFCMINPGTEGGIKKTLIGDKNLLMAYVHVAHDCVIGSHCILANGVTLAGHIEIGDYVNIGGLTAIHQFVRIAKGCMIAGKSALGKDVPPYCTVEGNRAFIRGLNRHRMRQLLESKDIDFIYALYKRLFRPIPSLRESAKLELEEHANNPFVKEICSFILASSRGVAYKSSEYSSEEKQEE
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1048_HAEIN
Sequence: MKKLIAVAVLSACGSLAHANTNIPNYNTDAHLYEFTQTYDLVVPKGSQGQTNLWVPLPFNGEYQQVKSIHFEGNYMNAYVTENNKYGAKTLFATWNKDAQKRDLKVMMVIETKDREPMVKGALENYTPPKDIQYSVDVQEYLKATPHIKTDGIVKEFPDKILGKETNPLKKAELIHHWFVKNMERDNSVLGCGDGDVEKILTTGVLKGKCTDINSVFVALARAAGIPAREIFGIRLGAAEKMGKYSKGAFGSANEQGIANVSGGQHCRAEFYLAGFGWVPVDSADVAKMRLAEKKSVEDKDTQAVAKYLFGNWEANWVGFNHARDFDLYPQPELAPINNFGYPYAEVGGDPLNSFDPKEFKYDYVSKKL
What are the official names of this protein?
Uncharacterized protein HI_1048.
Protein: AA3R_MOUSE
Sequence: MEADNTTETDWLNITYITMEAAIGLCAVVGNMLVIWVVKLNPTLRTTTVYFIVSLALADIAVGVLVIPLAIAVSLQVKMHFYACLFMSCVLLIFTHASIMSLLAIAVHRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKATLASSQNSSTLLCHFRSVVSLDYMVFFSFITWILVPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFDVKIPDVAMCLGILLSHANSMMNPIVYACKIKKFKETYFLILRAVRLCQTSDSLDSNMEQTTE
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.
What are the official names of this protein?
Adenosine receptor A3, A3AR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FTSH_HAEIN
Sequence: MVKNLVLWVVVAVIMMTAYQSFNSSSVENSTDYTTFVYDVSNGQVTAARFDANEITVTKTDGSKYSTVMPPLEDKKLLDDLLSKKVKVEGTPFERRGFLSQILISWFPMLFLVGVWVFFMRQMQGGGGKAMSFGKSRAKMLNQDQIKVTFADVAGCDEAKEEVGEIVDFLRDPNKFQNLGGKIPKGILMVGPPGTGKTLLARAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKNAPCLIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFSGNDGVIVIAATNRPDVLDPALTRPGRFDRQVVVGLPDVKGREQILKVHMRKVSVAQDVDAMTLARGTPGYSGADLANLVNEAALFAARVNKRTVTMLEFEKAKDKINMGPERRTMIMTDKQKESTAYHEAGHAIVGYLVPEHDPVHKVTIIPRGRALGVTFFLPEGDQISISQKQLESKLSTLYAGRLAEDLIYGEENISTGASNDIKVATNIARNMVTQWGFSEKLGPILYTEDEGEVFLGRSMAKAKHMSDETAHSIDEEVRAIVNRNYARAREILIDNMDILHAMKDALVKYETIEEEQIKQLMNREPVTPPSGWGEPKTQQAAYANSTTNDTKPESAVENTDDFNV
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: RAF1_MAIZE
Sequence: MLSLSHPHPHPAASTTAPRHQRTAPVWHRRRASHIAASAILLPGGGSTGGRGGPGDRRLPFTPPPMAPPGQLYQPFHPPPSPLPPSLRNLDLSERLQILRDRMGLWHEYAPLISSLSRDGFNPSSIQEATGISGVEQNCLVVASQVRDSLLDDRAAAFPPDLLPYFDSLGGPEVLYELRFLNARQRADAARHAIGYRLEPKGVRELARAMKGFPRWRGEEGWEAFSKDSPADCLAFARFRQSREAIDVQDRVAELERALQVVETESGRARVELELERARRKAAGEEEVDEEGEEDDAAASLRPGVTVVRLRYGEVAEATTVILLPVVRETDGVAAMESAPRRAKTDVGLGVVEVDRAWARWAVVPGWGPVAEAADDAVVVELADGRRLPWRMSDEEPVLVIANRSKKEVVEEGVYVLEREGRLVVERGKKLAEQGIAAAAAEVVIVVRPPKDEDDMVSDEEWD
What is the function of this protein?
Required for assembly or stability of RuBisCO.  Acts at a postchaperonin step to fold and/or assemble the large subunit (LS) into RuBisCO.
What are the official names of this protein?
Rubisco accumulation factor 1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the RAF family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL17_UREP2
Sequence: MSYINKPGKTRAWRKMVSRQQVSDVISHGSIVTTKTKAKESQRHVDHLITLAKKNTLASRRAAAAILLGTNQHSADDLLRKLFNELGPKYANRAGGYTRVIKLGNRPGDNTEEAVLQLV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: ACUK_ASPTN
Sequence: MKVESRENQPSAASADRSGADQESGAAERPDPSKKTDDGKPHAPAENGQKPPSNAKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACTDGVRKKAKYLHDAPDGALMPGVGGNFYSSNNNNSSMRNNLPLSRNGANAVNANAQQNTGANFYPTPQSTSYNVYQENPINQSSFTSQSPVSPTFNLKTNPTARTNSLSSVGQQPPTTTGVSGPNPQNPFAGALFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPSDSATQRGSMGRSGSAQFSNTPITGQPGFGESPGGQQPFMFGDPLLNEWPGGQASGQAHVNVGGVYPQSGQGSVIPGHLSKTDAPHAFTIESGPNFASPSATTSPQMTSGFDDHALNNAVAKSNGMANGQRPTISTPSLKHQSLQIGAKRRPRNPSSIYESVKEPYAYTNRFHNLTACIQRRFSPQKTLQIAKALASIRPSFIATTKTLNRDDLIFMEKCFQRTLWEYEDFINACGTPTIVCRRTGEIAAVGKEFSILTGWKKDVLLGKEPNLNVNTGGSSLPGSGTTSRSFTPRGSVGESTAPGRPQPVFLAELLDDDSVVEFYEDFARLAFGDSRGSVMTTCKLLKYKTKEDMELAQSDDNQRWNNHLRKGGIASEAGMNQLGFKDGKVECAYCWTVKRDVFDIPMLIVMNFLPCI
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes (By similarity).
What are the official names of this protein?
Transcription activator of gluconeogenesis acuK.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CBXH1_CAEEL
Sequence: MSRQNPVRSTRGNSLRAREAQQAQDAPLFQESSSNVFVVEKVLNKRLTRGGSEYYIKWQGFPESECSWEPIENLQCDRMIQEYEKEAAKRTTRKRRYSPQPSTSSSAELQPSTSDEWAGKTLKTIIGITKAPGELHFLCKFSDDSVHLIPLREANVRFPSQVIKFYETRLVLQGVSPTIPGGMS
What is the function of this protein?
Seems to be involved in transcriptional silencing in heterochromatin-like complexes (By similarity).  Involved in epigenetic repression (By similarity).  Probably does not act as global transcriptional repressor (PubMed:23028351).  Plays a role in linking epigenetic regulation with the innate immune response (PubMed:22083954).  Acting in concert with chromobox protein homolog hpl-2 and histone H1 protein his-24, involved in reproduction, somatic gonad development, male tail development and vulval cell fate decisions; perhaps as a result of modulating expression of Hox genes mab-5 and egl-5 (PubMed:23028351, PubMed:16905130).  Role in growth and somatic gonad development is antagonized by histone-lysine N-methyltransferase set-2/SET1 (PubMed:17967446).  Required for larval development, acting redundantly with hpl-2 (PubMed:26476455, PubMed:16905130).  Plays a role in the formation of the vulva and in fertility, acting together with a CoREST-like complex, and hpl-2 (PubMed:26476455, PubMed:16905130).
What are the official names of this protein?
Chromobox protein homolog hpl-1, HP1-like heterochromatin protein 1.
What are the subcellular locations of this protein?
Nucleus. Note=Partially co-localizes with histone H3 tails methylated at 'Lys-9' (H3K9me3) and 'Lys-23'(H3K23me2) in chromatin (PubMed:26476455). Localizes to distinct nuclear foci, not overlapping significantly with hpl-2, in embryonic cells (PubMed:26476455, PubMed:16905130).
Protein: ATPA_PSYCK
Sequence: MQQLNPAEISNLIKQRIQDLDAGATAKNEGTIVKVSDGIVQIHGLEDAMYGEMIEFEGEVYGMALNLERDSVGAVVLGDFLKLQEGQKAYCTGRILEVPVGPELLGRVVDALGNPIDGKGPINAKMTDKVEKIAPGVIDRQSVDQPVMTGYKSVDTMIPIGRGQRELIIGDRQTGKTAMAIDAIIAQKSSGIKCVYVAIGQKRSTIANVVRKLEQTGALEYTTVVVASASEPAALQYIAPYSGCTMGEYFRDRGEDALIVFDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVNAAYVEKFTNGEVVGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESSLFNSGIRPAVNAGISVSRVGGAAQTKIIKKLSGGIRTALAQYRELAAFAQFASDLDDVTREQLDHGERVTELMKQKQYQPMSISEQAAVIYASNEGFLADVPVEKIGSFEEAYLRYMHDEQADLMKEIDDTANYNDDIAGRLKSSLETFKQNHSY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TFKLL_HUMAN
Sequence: METGRQRGASAEMFAMPQGLKGSNKDGIPEDLDGNLEEPRDQESELRSQDVMDLTEGDNEASASAPPAAKRQKTDTKGKKERKPTVDAEEAQMTTLLYAMSEEQLSRYEVCRRSAFPKARIAALMQSITGRSVSENTAIAMAGIAKVLVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNYKKIMF
What are the official names of this protein?
TATA-box-binding protein-associated factor 11-like protein 12.
What is the protein family that this protein belongs to?
Belongs to the TAF11 family.
Protein: PURQ_SYNJA
Sequence: MAKVRFGIVVFPGSNCDRDVAWVTRGLLGCPTRLIWHRETDLSGLDVVVLPGGFSYGDYLRAGALARFAPVMGSLAEHGARGGYVLGICNGFQILTEAGLLPGALVRNANLHFICDRVGIRVERQDLPWTSAYPCGATLTLPIAHGEGRYVCDADTLKQLQDRGQIVFRYAPVAPNGSVDNIAGICDPSGRILGLMPHPERAADPDLPGQDGIPFWQSIVQSLAG
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCAP_CCHFV
Sequence: MENKIEVNNKDEMNKWFEEFKKGNGLVDTFTNPYSFCESVPNLERFVFQMASATDDAQKDSIYASALVEATKFCAPIYECAWVSSTGIVKKGLEWFEKNAGTIKSWDESYIELKVEVPKIEQLANYQQAALKWRKDIGFRVNANTAALSHKVLAEYKVPGEIVMSVKEMLSDMIRRRNLILNRGGDENPRGPVSREHVEWCREFVKGKYIMAFNPPWGDINKSGRSGIALVATGLAKLAETEGKGVFDEAKKTVEALNGYLDKHKDEVDKASADNMITNLLKHIAKAQELYKNSSALRAQGAQIDTAFSSYYWLYKAGVTPETFPTVSQFLFELGKQPRGTKKMKKALLSTPMKWGKKLYELFADDSFQQNRIYMHPAVLTAGRISEMGVCFGTIPVANPDDAAQGSGHTKSILNLRTNTETNNPCAKTIVKLFEIQKTGFNIQDMDIVASEHLLHQSLVGKQSPFQNAYNVKGNATSANII
What is the function of this protein?
Binds dsRNA and ssRNA and probably participates in the packaging of viral genome (By similarity).  In the dsRNA binding mode, the nucleocapsid protein specifically binds to the vRNA panhandle secondary structure formed at the termini of viral genome (By similarity).  Does not discriminate between viral and nonviral RNAs through ssRNA binding mode (By similarity).  Displays dsDNA endonuclease activity that is sequence non-specific (By similarity).
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the nairovirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Note=Internal protein of virus particle.
Protein: RS3_STRP8
Sequence: MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFINKELADASVSTIEIERAVNKVIVSLHTAKPGMVIGKGGANVDALRGQLNKLTGKQVHINIIEIKQPDLDAHLVGENIARQLEQRVAFRRAQKQAIQRTMRAGAKGIKTQVSGRLNGADIARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CLTR1_CAVPO
Sequence: MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
What is the function of this protein?
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma.  Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung.  This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity).
What are the official names of this protein?
Cysteinyl leukotriene receptor 1, CysLTR1, Cysteinyl leukotriene D4 receptor, LTD4 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: F37C4_CAEEL
Sequence: MAHIVQTHKLTLHDVAIDQALVYSSDSNCAELKRTFQVELAHGYNEVKVQNLPFDLVQDSIRVSGAGEAVIHDVSVKNQEGAEFVIPERVLAIKAIFEEKERAKDKVADSRVAVQKRIEGLDNLITEVAKHGKDGAFHFDGRTIESLNALHGFHQDTTVDLRAQIRTLDQDLRKAEEEYARASQDYDNTGYRWRNSAQYASIIVESEAGGAAQLTITYQVNNVSWTPFYDIRVTAGVEAEMHVTYFGKVRQYSGEDWKTVPLVLSTARPAHGVKQLPKLGALEASIVVPEPECNRGGRGGYGGGYAQDSVVMACAAPMMEMGRSRKSMKMSYAAVKSSNIASEFSIGRPATIDDRTDEYKVNIGQFTLDTKLSNVTVPSRNATAFLVANSVNTSDYPLVAGQASIFLDGAFVNKTEFEDAVVSQKFEVSLGVDPNIRIEYKPVRNYQEQSGTVEKINSQVTEKTTAVTNLRPNSVLLTIREQLPRSTDSRIKVHLNTPEAVEVDEASVEPTVGAAITPEKILDYTVQLAPGQSSTFVVKYTTEHPQAEQIRYEEKF
What are the official names of this protein?
Protein F37C4.5.
Protein: CHIN_BOVIN
Sequence: MPSKESWSGRKTNRATVHKSKQEGRQQDLLIAALGMKLGSQKSSVTIWQPLKLFAYSQLTSLVRRATLKENEQIPKYEKVHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKARTTKRPMVVDMCIREIEARGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF
What is the function of this protein?
GTPase-activating protein for p21-rac and a phorbol ester receptor.  Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance (By similarity).
What are the official names of this protein?
N-chimaerin, A-chimaerin, Alpha-chimerin, N-chimerin, NC, Rho GTPase-activating protein 2.
Protein: SCAA_DICDI
Sequence: MSSLDPSLSTTPSTNRRGTFSKAKSFRRAALNLEPQGTPGQPHAFRFLSGEEYSGPDIIENIKKPININIESEEYKTPLFLGANGTLYNKYYIPIKIIGIDEPLPQTGLSPSLSSSSSSSSSPSPPTTTSTTPPPPNNNNNSKQIKKNNSISDLTPYLNFNSTDQIYTSFPESMAFDDYMDYEESLVEWKRQVEQNLGIIQLPHSIGRTYPRPKVIHEQLFRKNSEASNDDSISYDIERKLTDSDIKETNSSVNDDGESFSHSPTLRGNNGSSLSVGGGGDNHDNTSNKDNASSQGTNHGVTLNHPNSGINLRERSNSDTSTGSFEGTQLDGSSPMDGSPSTGSLAGFVANGTRSRTNSITYFDQRNQRSNSLSPKHSMLQSRLADSQSLDSSMYGKMGRSGSGFGMDHESWFLQKDPWDSQLILTEPHPDLFSTYEEYEYAMKNWAHEVITKTSILPPHPGQFIQLPKNSELSTDDGSGGGSGGSGVDGVGGNHQLGGSARHMLEMDFEMAKNQSNWTLRPIIRPIITEETMIFNRILSQSNLKHTEYDHLFSIDQELPPSQVWKTLDSDEKLKITETIDRWYRKKLTIQRQTSTWFRGGLWANHFLMPNIQSGWRESVSKKSSILPPLSLKALRRLDINSEADGKRVEHSFPIPELPINFNKLLAPDMNLQYFLGMLEMPTAHSLSSATGGQQQGGSGGGSGGSGSGSGSGSGLNMSGTSGSSGKSEKDKDKETANYIAMHSINNTTNVGTKEDRRQYTKILQTYEQRLQFSFRLDALNSWSEGGYTPMELQEKKLDIEQLVAAPGFDLQNGVWSLVNNSAHFLDKFQETFDQVDLRLYAPAIPMLPAIVPSVFINAGGGSGGGSGGASGGGISTSSGTSPNIVRPGSSSIGGGQPPSSPHIPSGSSLLSSPPNRQGSTGSFSFIGSPGGGGKISPTNSSSLESPRTQSQLAAVVERGSSPRSHSGGSISTHPNTPSVSSNTFLSLINTDSFPELLKFLDLTNEKLALGKISSLVLLVLTSELKGTMVIENILFSKDLQSLYRLARAISFFDAVPLDLFTYPTHLNEMLTPSIFKGSTQEVVRLVFVYYYLGIIQERLNFFSNNVGILGFVNSSRKDAAERIGIQFQNDREFLYKIFKALGRKSILVSNCFLFVLIQLIKMSESPTVQSLLKGELLTHIRDLSASKFSHSRFAAKRLYQILQEDPWKEFLMASYAESIKKNESQHLTDLTTMKEGPKLAIPSISLISELTFNFCVGVLENINSTPIPKPIYKFILNDSIFFQLCNAIVKCKNFTQSTQIVSKVFASLCKVLAKFNLFKNSDSIKSGGKVDPKKQNDVETGVAISPTLLFEIIGFLQNSSLDNNRYCSIIKTNMLIALRQLLKQSEIFDSIKKEGNLYNKFLIPACRDGKNVEFNRNVWRLFFQMIRFHHGHIEYLEKSKYLNALMDIISLNAGNVVLTNALHYLSKLFSLVSYETRKNALRAPGTLSIDTKYSEKDVKSLLNFFVERSCFIKFHMIYKKLTENTEGIQIDQRLLINITTFYRIISFLPSCQKLLKDTLKNPEYKTGIIQVSKMYKPSETF
What is the function of this protein?
Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay (PubMed:20493808).  The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway (PubMed:20493808).  ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A (PubMed:20493808).
What are the official names of this protein?
Sca1 complex scaffold protein scaA.
What are the subcellular locations of this protein?
Cell membrane. Note=The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells (PubMed:20493808). Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1 (PubMed:20493808).
Protein: MRL7_ORYSJ
Sequence: MLRLPTLLPLKPSPPTTGLNPIHGRRHGHHPSRLLASSAPPPPPPRPPKPEPRTSHENLGDDTPDFPTTKPRKPRRGRRSEAAAVEDFVRGRLEQVFASIRERDPEVLEGKGDILKRKEELSDEEGKEGTGEEEGELKAVVEEEDPSWPLDADIGWGIRASEYFDKHSIKNVTVDGVEIDWEREVEEGWVKEINCLEWESFAFHPSPLIVLVFERYNRAADNWKFLQELEKAAKVYWNSKDRLPPRTVKVDMNIERDLAFALQVKECPQLLFLRGNKILYREKELRTADELVQMIAHFYYNAKRPSCVNPEAIAPPC
What is the function of this protein?
Plays an essential role in early steps of chloroplast development.  Involved in the regulation of plastid gene expression.  Required for the proper function of the plastid transcriptional machinery and protein accumulation in thylakoid membranes.  May function as molecular chaperone to ensure proper organization of the nucleoids in chloroplasts.
What are the official names of this protein?
Thioredoxin-like fold domain-containing protein MRL7 homolog, chloroplastic, OsMRL7.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, chloroplast stroma, chloroplast nucleoid.
Protein: RL3_NOCSJ
Sequence: MTIERNMKGLLGTKLGMTQVWDENNRVVPVTVIAAGTNVVTQVRTPATDGYNAIQVGYGEIDGRKVTKPQAGHFGKAGTTPRRHLVEIRTALAADYTVGQELAVDTFAAGEEIDVTGTSKGKGFAGTMKRHGFAGVSASHGAHRNHRKPGSIGACATPGRVFKGVRMAGRMGTDTVTTQNVTVHAVDTAKGLILLKGAVPGPKGGLVVLRSAAKSSLTSGKEV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: Y1821_STAAB
Sequence: MNDQWYKHLIGARTIKTGIAIFLTAVFCMALDLTPIYAILTAVVTIEPTAKASLIKGYRRLPATVIGAGFAVLFTYLFGDQSPFTYALSATFTILFCTKLKLQVGTNVAVLTSLAMIPGIHDAYIFNFLSRTLTAIIGLVTSGLINFMVFPPKYYGQVEEKLSKTDALMYKLFYNRCQELILSRLQSDKSEKAYKNIFNLNNQVETLISYQRDELSYHKKKECDWKLLNQLTKRAYTNRLFITHLSNIIYLPKNTRVNFSGDEKMALLKISSSIKDIFYDGSFKREDDSVETLRSTIKALEISGENQIKSHILYEVLMIYRLLDSRYA
What are the official names of this protein?
UPF0421 protein SAB1821.
What is the protein family that this protein belongs to?
Belongs to the UPF0421 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y281_BUCAI
Sequence: MNKILVIILFSLVSLTWGTTWIAMKIATETIPPFFATGMRFLVASPILIILAYFTKTPLLFPYGQRWFQLIISIFYFSIPFALMLYGGMYVSSSVASIIFSSMPVAVLTVSFLYLKKKLFLTQKIGMFISLITLLTILLIELESQCFFQWKGILALLFALFSHAFIYSECQKKCLNVSVITFNALPSLLSGILLSTTSWFIESPHINTFSNRSILAIFYLGDFSGIFGILSYFYLQQKVSAFYASTVFLIFPVIAGFLENYIYKNAILLCEIWFIFPLIIGILLTLIPVNYLKKIRNKITRLSCLLF
What are the official names of this protein?
Uncharacterized transporter BU281.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KBX3_EUSVA
Sequence: MNSKLTVIVLLALITIASCGLINEKKVQQYLDEKLPNGVVKGALKSLVHKAAKNQNLCAFNVDTVGMCDADCKRQGKAKGVCHGTKCKCDVELSYKK
What is the function of this protein?
Ev37 selectively inhibits Kv1. 3/KCNA3 channel (IC(50)=0. 95 uM).  Both N-terminal and C-terminal domains are likely involved in the interaction with Kv1. 3, since neither Ev37-N (1-36) nor Ev37-C (37-78) block Kv1. 3 channel.
What are the official names of this protein?
Scorpine-like peptide Ev37.
What is the protein family that this protein belongs to?
Belongs to the long chain scorpion toxin family. Class 3 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ISC1_YEAST
Sequence: MYNRKDRDVHERKEDGQSEFEALNGTNAIMSDNSKAYSIKFLTFNTWGLKYVSKHRKERLRAIADKLAGHSMLTPISDELLPNGGDSNENEDYDVIALQEIWCVEDWKYLASACASKYPYQRLFHSGILTGPGLAILSKVPIESTFLYRFPINGRPSAVFRGDWYVGKSIAITVLNTGTRPIAIMNSHMHAPYAKQGDAAYLCHRSCQAWDFSRLIKLYRQAGYAVIVVGDLNSRPGSLPHKFLTQEAGLVDSWEQLHGKQDLAVIARLSPLQQLLKGCTTCDSLLNTWRAQRQPDEACRLDYALIDPDFLQTVDAGVRFTERIPHLDCSVSDHFAYSCTLNIVPQGTESRPSTSVKRAKTHDRELILQRYSNYETMIECIHTYLKTAQRQKFFRGLHFWASILLLIASLVVTTFTANKAGWSSIFWVLFAIAVSISGTIDGAISFLFGRSEIRALIEVEQEVLDAEHHLQTFLSEK
What is the function of this protein?
Responsible for the hydrolysis of the phosphosphingolipids (IPS), inositol phosphorylceramide (IPC), mannosylinositol phosphorylceramide (MIPC), and mannosyldiinositol phosphorylceramide (M(IP)2C) (PubMed:11006294).  Regulates sphingolipid metabolism in mitochondria, especially the formation of alpha-hydroxylated very long chain phytoceramides.  The generated ceramides contribute to the normal function of mitochondria (PubMed:17880915).  Also active on sphingomyelin (SM), but this activity is probably not physiologically relevant (PubMed:11006294).
What are the official names of this protein?
Inositol phosphosphingolipids phospholipase C, IPS phospholipase C, IPS-PLC, Neutral sphingomyelinase, N-SMase, nSMase.
What is the protein family that this protein belongs to?
Belongs to the neutral sphingomyelinase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Note=Localization is regulated in a growth-dependent manner. Predominantly in the ER during early growth and becomes associated with mitochondria in late logarithmic growth.
Protein: RSMJ_CHRVO
Sequence: MTATPLYCAEPARLDTARRLCERFSLPLIKQRPADGYWLELGSERLELLTTGKHGAVYAEFVEGAARHRREQGGGRGQPVAKAVGLKGAKDLPHVADATAGLGRDSFVLATLGCRVTMVERSPVAAALLADALERAQRDETTRDIAARMTLVHANSRNWLAGLTEAQRPDVVFVDPMFPDTDKKSAAAKKDMQAFQQVIGDDMDSAELLAAAIAAARVRVVVKRPRLGAAIAGVKPSAVLDGKSTRFDLYVIKALASG
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATE_THEVO
Sequence: MSLEQVIKEIEQSQEIKKKEILENTKNILDKMEAEKKAKIDEIRALYQEKMRAESSRITASIIDKANIEARSILRNKIEEILEGYVSAAQEILRNIRNMPEYPALLNKMIEVAKKYLGQDCIIKVDSKDKAVAPSSGITYSNIDPYGGILASSRDGKVELDLRVSSIMEEVLEKIKVKIYTRLEE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.