PharMolix/UniProtQA huggingface dataset:
Protein: HASP_MOUSE
Sequence: MAQAHPRSGTRLFRTYAARGVRGSQRQPGGLAEQWFQPPNLKRAFSSSLSDSNESPAVASDDPDDPDFPGSLVGQRRRRPRGSGSRNQRTLTNTPRVQRLRPRPPQKCSTPCSRLRPPPFPNCSPGCLGSDHSVCIQSRDSNELGTSASLFSSPASPGAPDPLYADSAVPGSFHLPAASLSEPSVPCPQVAATGDRYTGRALRAEASFRSSLFSLVNSGATEENKFGTDGENVKESCCERRQQMGNRLTDPDLTSPGKRKAACKKVVSQGVDQRDYEESSACKDLRVPGEISRPKRTGPLRKRKQQEATGTPPRHYHQSKKKRKASVSLWNLNTSQRDSWTKTRASFGFHKKKIITSVIEVCSSVASSSSRSLLSECSTPPIKNRAHLTVSSRCSSVYLLSPLKTLHVTDQRPSYAEKVYGECNQEGPIPFSDCLSTEKLERCEKIGEGVFGEVFQIINDQAPVALKIIAIEGLDLVNGSHQKTFEEILPEIIISKELSLLSSEAYNRTEGFIGLNSVHCVQGLYPPLLLKAWDHYNTTKRSANDRPDFFQEDQLFIILEFEFGGVDLERMKTKLSSVATAKSILHQITASLAVAEASLHFEHRDLHWGNVLLKKTNLKELRYTLNGKTSTIPTHGLQVNIIDYTLSRLERDGIVVFCDISAEEDLFTGEGDYQFEIYRLMRKENKNCWGEYHPYNNVLWLHYLTDKILNKMKFKTKCQSAAMKQIRKNLQHFHRTVLSFSSATDLLCQHSLFR
What is the function of this protein?
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis.  May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
What are the official names of this protein?
Serine/threonine-protein kinase haspin, Germ cell-specific gene 2 protein, Haploid germ cell-specific nuclear protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.
Protein: ATPG_MOUSE
Sequence: MFSRASVVGLSACAVQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARVYGTGSLALYEKADIKAPEDKKKHLIIGVSSDRGLCGAIHSSVAKQMKNEVAALTAAGKEVMIVGVGEKIKGILYRTHSDQFLVSFKDVGRKPPTFGDASVIALELLNSGYEFDEGSIIFNQFKSVISYKTEEKPIFSLNTIATAETMSIYDDIDADVLQNYQEYNLANLIYYSLKESTTSEQSARMTAMDNASKNASDMIDKLTLTFNRTRQAVITKELIEIISGAAALD
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(1) domain and the central stalk which is part of the complex rotary element.  The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
What are the official names of this protein?
ATP synthase subunit gamma, mitochondrial, ATP synthase F1 subunit gamma, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: CHMP7_CHICK
Sequence: MCSPGRAPPGPAPAGDLPPEWETDDERMAFLFSAFKQSREVNSTEWDSKMAFWVGLVLARGRRRGVVRTCLRELQNGFERRGSVPLGLGTVLRELLRRGKMQRESDFMASVDSSWISWGVGVFILKPLKWTLSSVLGDSKVPEEEEVLIYVELLQEKAEEVYRLYQNSVLSSHPVVALSELRSLCAGVCPDERTFYLLLLQLQKEKKVTILEQNGEKIVKFARGLHAKVSPMNDVDIGVYQLMQSEQLLSQKVESLSQEAEKCKDDARSACRAGKKQLALRCLKSKRRTERRIEELHSKLDAVQGILDRIYASQTDQMVFNAYQAGVGALKLSMKDVTVEKAENLVDQIQELCDTQDEVAQTLAGAGVNGLEMDSEELEKELDSLLQDSAKEPVHLHPVPQKDSGFAGAISDAELEAELEKLSVCDGDLAQKTPSASSEPQTALGLNL
What is the function of this protein?
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (By similarity).  Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (By similarity).  Recruited to the reforming NE during anaphase by LEMD2 (By similarity).  Plays a role in the endosomal sorting pathway (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 7, Chromatin-modifying protein 7.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area. Localizes to the reforming nuclear envelope on chromatin disks during late anaphase.
Protein: PDXH_PECAS
Sequence: MTQERSPSDGTPLIQPADIADIRREYTRGGLRRGDLPANPLDLFERWLKQACEAKLADPTAMSVATVDERGQPYQRIVLLKHYDEKGMVFYTNMGSRKAHHLENNPRISLLFPWHVLERQVMVLGRVEKLPALEVLKYFHSRPKDSQIGAWVSKQSSRISARGVLESKFLELKQKFQNGEVPLPSFWGGFRVVIDSVEFWQGGEHRLHDRFFYQRQEENWQIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: IFRH_MAIZE
Sequence: MASEKSKILVVGGTGYLGRHVVAASARLGHPTSALVRDTAPSDPAKAALLKSFQDAGVTLLKGDLYDQASLVSAVKGADVVISVLGSMQIADQSRLVDAIKEAGNVKRFFPSEFGLDVDRTGIVEPAKSILGAKVGIRRATEAAGIPYTYAVAGFFAGFGLPKVGQVLAPGPPADKAVVLGDGDTKAVFVEEGDIATYTVLAADDPRAENKVLYIKPPANTLSHNELLSLWEKKTGKTFRREYVPEEAVLKQIQESPIPLNIILAIGHAAFVRGEQTGFEIDPAKGVDASELYPDVKYTTVDEYLNRFL
What is the function of this protein?
Reductase that may be involved in a late step of alkaloid biosynthesis.
What are the official names of this protein?
Isoflavone reductase homolog IRL.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCG2_RAT
Sequence: MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGVKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKDSKDSLHANTANRRTTPV
What is the function of this protein?
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs).  Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization.  Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.  Thought to stabilize the calcium channel in an inactivated (closed) state.
What are the official names of this protein?
Voltage-dependent calcium channel gamma-2 subunit, Neuronal voltage-gated calcium channel gamma-2 subunit, Stargazin, Transmembrane AMPAR regulatory protein gamma-2, TARP gamma-2.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Synapse, synaptosome.
Protein: SECB_EHRRG
Sequence: MSYKLDVKAQYIKDLSFENPNSPQIFVMMSKATPEINISVNVSSISLPVKADDQKSGTENLSSLYEVTLQVNAEARIQNTVAFICEIKYCGVFSIKSDTENNEIDLSHQEVKDMLLVAAPSILFPFVRELIARATSSSGFPPLMLDIVDFRTMYENQLKQGVGQNDNDNSVDNV
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBED_ECOHS
Sequence: MKTKLNELLEFPTPFTYKVMGQALPELVDQVVEVVQRHAPGDYTPTVKPSSKGNYHSVSITINATHIEQVETLYEELGKIDIVRMVL
What are the official names of this protein?
UPF0250 protein YbeD.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: Y106_COLP3
Sequence: MITLSAEQCRIIGVMLEKETTTPEQYPLSLNGITTGCNQKSNRDPVMSLSESDVQNLVDELVQMNQLMVDQKASTRVNKYFHRFCDTEFGNLKFTPQQRAVICVLFLRGPQTPGELRTRTNRLADFADVSEVDNTLTQLQDLNGLTLVRKLEREPGKRESRYVHLLSDVDESSFTQAVTTQTEVVLSEEQTSLTQRVTELEQQVASLTEQINCITELLNDD
What are the official names of this protein?
UPF0502 protein CPS_0106.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: NANT_SALCH
Sequence: MSTSTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQSEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVSSIILFSVGTLACGFAPGYTTMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINILMTFVAAAALWFCFAGNLQNAAIVAGLGLLCAVIFISFMVQSSGKRWPTGVMLMLVVLFAFLYSWPIQALLPTYLKTELAYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQILIIPVFAIGGTNVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTAQRAAGLGFTYNVGALGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDDKPFSGAVPLGSGKGAFVKTKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid.
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AMPA_HELPG
Sequence: MLKIKLEKTTFENAKAECSLVFIVNKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCGTHSKDNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPCEKTCANSLEKSAKEALKYAEIMTESLNIVRDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVYDEKFLEEKKMNAFLAVNKASLGVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNVLAKLGVEAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGAGVRACTAFVEELLKKA
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_VIBVU
Sequence: MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGLAAGLDKNGECIEAFDAMGFGFVEVGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGVDNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICMEKVYEYAGYIAVNISSPNTPGLRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKIDGVIATNTTLDRTMVEGMKHAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDSYVAAKEKMLAGADLVQVYSGFIYHGPGLVRDIVKNL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: THYX_CORGL
Sequence: MAEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAYLRHIMEVGHTALLEHANATMYIRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPTLIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNALLRKKQARQAARAVLPNATESRIVVSGNFRTWRHFIGMRASEHADVEIREVAVECLRKLQVAAPTVFGDFEIETLADGSQMATSPYVMDF
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: MSCL_XANOP
Sequence: MGMVSEFKQFAIRGNVIDLAVGVVIGAAFGKIVTALVEKIIMPPIGWAIGNVDFSRLAWVLKPAGVDATGKDIPAVAIGYGDFINTVVQFVIIAFAIFLLVKLINRVTNRKPDAPKGPSEEVLLLREIRDSLKNDTLKSG
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: G6PI_STRM5
Sequence: MTTNNGFDSLHSHAQRLKGASIPSLLAAEPGRVQELALRVGPLYVSFARQTYDAAALQALLALAAERDVGAAITRLFRGEQVNLTEGRAALHTALRGDVVDAPVAAEAYATARDIRQRMGVLVRALEDSGVTDVVSVGIGGSDLGPRLVADALRPVTGARLRVHFVSNVDGAAMQRTLATLDPAKTAGILISKTFGTQETLLNGQILHDWLGGSERLYAVSANPERAAKAFAIAADRVLPMWDWVGGRYSLWSAVGFPIALAIGFERFEQLLEGAAQMDAHALDAPLERNLPVLHGLTDIWNRNLLGYATHAVMTYDQRLALLPAYLQQLVMESLGKRVQRDGQPVTTDTVPVWWGGAGTDVQHSFFQALHQGTSIIPADFIGCVHNDDPYTINHQALLANLLAQTEALANGQGSDDPHRDYPGGRPSTLILLDALTPQALGALIAMYEHAVYVQSVIWNINAFDQFGVELGKQLASGLLPALQGEDVAVADLMTREILAQLKR
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_BRUME
Sequence: MNMTKTAMLIALMTVMFMSIGYLLGGGGGMMIALVIAVAMNLFGYWNSDKMVLRMYNAQEVDERSAPEYYRMVSGLAANAGLPMPKVYIIHEDQPNAFATGRNPENAAVAATTGLLNWLSPEEVAGVMAHELAHVQNRDTLTMTIVATLAGAISMLGNFAFFLGGNRENGNGVMGVVGTLLAMIVAPFGAMIVQMAVSRTREYAADKRGAEICGNPLWLSSALGKIARGAKVIPNEEAEHNPATAHMFIINPLSGRGADNLFSTHPDTDNRIAALEQMAAETGIRSAAMTARAAAPSQNSGPWGQRSDNAGGNSNGGSRYRGPWS
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPC8_DICDI
Sequence: MFHLITIEDKVRIAPSQFNNEVQTIEDEIEKKYTSKVVLNAGLFVALYDILGTGDSYVHSGDGGAHLMVRFRMVVFKPFKGEVLEGVIKKSSRQSIQISLGFFHEIYLNPIELPNPSNYNQEEGLWYWEWNENQLFFEDGGRVRFKIDQVEFNPEISQPAPSPKNVNTEAMDSYSLREYKEKQIENENLLKQVKSPLILKVSMREAGLGMVSWWTNQSAGDDDENEEDGGENQDDEVAEDDGGEEPTIEEDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase III subunit rpc8, RNA polymerase III subunit C8, DNA-directed RNA polymerase III subunit H.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CDGT_BACOH
Sequence: MKNLTVLLKTIPLALLLFILLSLPTAAQADVTNKVNYTRDVIYQIVTDRFSDGDPSNNPTGAIYSQDCSDLHKYCGGDWQGIIDKINDGYLTDLGITAIWISQPVENVYALHPSGYTSYHGYWARDYKRTNPFYGDFSDFDRLMDTAHSNGIKVIMDFTPNHSSPALETDPSYAENGAVYNDGVLIGNYSNDPNNLFHHNGGTDFSSYEDSIYRNLYDLADYDLNNTVMDQYLKESIKLWLDKGIDGIRVDAVKHMSEGWQTSLMSDIYAHEPVFTFGEWFLGSGEVDPQNHHFANESGMSLLDFQFGQTIRDVLMDGSSNWYDFNEMIASTEEDYDEVIDQVTFIDNHDMSRFSFEQSSNRHTDIALAVLLTSRGVPTIYYGTEQYLTGGNDPENRKPMSDFDRTTNSYQIISTLASLRQNNPALGYGNTSERWINSDVYIYERSFGDSVVLTAVNSGDTSYTINNLNTSLPQGQYTDELQQLLDGNEITVNSNGAVDSFQLSANGVSVWQITEEHASPLIGHVGPMMGKHGNTVTITGEGFGDNEGSVLFDSDFSDVLSWSDTKIEVSVPDVTAGHYDISVVNAGDSQSPTYDKFEVLTGDQVSIRFAVNNATTSLGTNLYMVGNVNELGNWDPDQAIGPMFNQVMYQYPTWYYDISVPAEENLEYKFIKKDSSGNVVWESGNNHTYTTPATGTDTVLVDWQ
What are the official names of this protein?
Cyclomaltodextrin glucanotransferase, Cyclodextrin-glycosyltransferase, CGTase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MEND_MYCBO
Sequence: MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: ST1B1_MOUSE
Sequence: MSASEDVWRKDLKMIHGYPMIYAFALNWERIEEFQSTPGDIVITTYPKSGTTWLSEIVDMVLNDGNVEKCKRDVITSKVPMLELSVPGIRISGVELLKKTPSPRIIKTHLPIDLLPKSFWENKCKMIYLARNGKDVAVSYYHFDLMNSINPLPGTWEEYLEKFLAGNVAYGSWFDHVKSWWEKREEHPLLYLYYEELKQNPKKEIKKIASFLDKTLDEEALDRIVHHTSFEMMKENPLVNYTHLPTAMMDHSKSPFMRKGIVGDWKNYFTMTQTEQFDAVYKKKMSGTTLEFCTDIQSA
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:9644246).  May play a role in gut microbiota-host metabolic interaction.  O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria.  The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (By similarity).
What are the official names of this protein?
Sulfotransferase 1B1, ST1B1, DOPA/tyrosine sulfotransferase, Sulfotransferase family cytosolic 1B member 1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1377_STRT1
Sequence: MKKQAFSSEQYLNLQRDHILERINQFDGKLYLEFGGKMLEDFHAARVLPGYEPDNKIKLLQEFKDQVEVVIAINASNIEHSKARGDLGISYDQEVLRLIDKFNELNIYVGSVVITQYSGQPAADAFRNQLEKNGITSYIHYPIKGYPTDINHIISPEGMGKNDYIKTSRNLIVVTAPGPGSGKLATCLSNMYHDQINGIKSGYAKFETFPVWNLPLHHPVNLAYEAATADLDDVNMIDPFHLETYGKTTVNYNRDIEIFPVLKRMLERILGESPYASPTDMGVNMVGFAITDDEAAKEASKQEIIRRYYQTVLDFKNERVPETAVKKIELLMNDLGITPEDRQVVVAARAKAEETGGSALALELPNGQIVTGKNSELFGPTAAALINAIKTSAGIDKDTKLIEPEVVKPIQSLKIDHLGSRNPRLHSNEILIALAITAANNADAARAMKELSNLKGSEAHSTIILTDEDKNVLRKLGINVTFDPYYQYDKLYRK
What are the official names of this protein?
UPF0371 protein str1377.
What is the protein family that this protein belongs to?
Belongs to the UPF0371 family.
Protein: LUM_BOVIN
Sequence: MNLGVFPLLLALIGGASSTYPDYYEYYDFPQALYGRSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDDKAFENVTDLQWLILDHNLLENSKIKGKVFSKLKQLKKLHINYNNLTESVGPLPKSLVDLQLTNNKISKLGSFDGLVNLTFIHLQHNQLKEDAVSAALKGLKSLEYLDLSFNQMTKLPSGLPVSLLTLYLDNNKISNIPDEYFKRFSALQYLRLSHNELADSGVPGNSFNVSSLLELDLSYNKLKSIPTVNENLENYYLEVNELEKFDVKSFCKILGPLSYSKIKHLRLDGNHITQTSLPPDMYECLRVANEITVN
What are the official names of this protein?
Lumican, Corneal keratan sulfate proteoglycan 37B core protein, Keratan sulfate proteoglycan, KSPG.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: UBIQP_TETPY
Sequence: MQIFVKTLTGKTITLDVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ
What is the function of this protein?
Ubiquitin exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Polyubiquitin.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RLMH_DEIGD
Sequence: MRLHLITVGEPKLAYARAGWDEYEKRLRRYHKVQVTRVGGRTGAQASEAIARAAGRAPLILLDPRGEQFTSESLSAYLDAQALDGRGELAFAVGGPEGHTDDLRARAHRLWSLSLLTLPHDLAMILLLEALYRAATISAGEPYHRGST
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_CHLPB
Sequence: MGKAAYHLPVMVREVVAWLVRRAGIYVDGTLGGGGHSLAILRALRDKGLEKGSFLIGIDQDSFAIAEAERTLASFRERTRLVQGNFREIADIVSTLRENQLRGMEVAGILLDLGVSSFQIDTSERGFSYLRSGPLDMRMEPDEGQSAADIVNTFEERELADIFFRFGEEKKSRRIASAICSWRNERGVIRGTQDLAAIVRSVVSVPDQQIKSLSRIFQALRIAVNDELGALESALKEGAASLSPQGRMAVMSYHSIEDRMVKHYFRTLAADDWGPKGVALREPLHKAAFTLVTRKALIAGDDEVNENSRARSAKMRVIERKMYSGEVSESDS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.