Protein: NPS2_CERS8
Sequence: MSAHTRTDCDHPELPKLATVISGYRHCDLPDLSSDRFPASTTYSVSACIKESLISTQVDVLDARAPFAVLVATIGRVLGAYCGCTDVILALTDQDCEDLRTARITWDENTQWADLLHTVLQSLSGDTSFRITVPAIREALGLTEKQAPCLALVRDAPSSDYDNTDFPLVFNWDISTFTLRLFTSERHLHPSGADLLASQIASLLVPALTNPATQVFRLPDLQADLLSIYEKLTFEDRCQAYSRVPPVRLATDHLTLRLASQANDVAVEWYGALADDHHPGTSQPETMTFGEWHRRANQMARWLVARGLEKGDKVAVCMKRDTSYHVSLIAVLKAGACYVPIDPELPSERQSYIACDSGARFVLVSSETASTSIFGDIALEISSNEARRGIEAESDEELDLATPDDVSYLLYTSGTTGTPKGCVLTHRGLSEAVWALSAVCAEVDMEEGHMGNYLSIASVAFDVHLAEIFIPLARGMSIVSAPRSTLLEDLPYFIKELKISHLGIVPSLIEATMGSIQEDVESGGSTTLRYIASGGEKMSDAILDKWANHPTVRLANFYGPSEVTIGCAARFMDKTTPRANIGHPFASVSAFVVDENMNILLRGAPGELVVEGPLVGVGYHGRPDLTEKVFLEFPERGAGRWAYRTGDLVRMMPDGTLEVIGRIDTQIKLRGVRIESEGISSIVRSAGLPEHTLDVVTILGKHPAIGVEQLVSFIVWDQSTSVAVRKSTKPTVIAPSGNLLTKLSAACERELASYMRPSHFIPLNFMPLSSNGKNDAKLLTRVFQELDMDVLGSLMSRGSSTSVGSPNSGRTQLTKAEGQLLEIAKKHVHVPSGAANPNTNLFRYGLDSMSAVRLAAELRRTFSKVITASDILKSPSLEQIAKALDASSSSDQEQSPVESFVQRFSAERMQDVTEAYDSHVISAIYPPFPLQEGILYRSVNADTLYVQHVLLELAPGVSVDKLRQAWIDVVISSPILRTVFHFGRDLVQVVLHSDDVSRDIGEDVVHCDDAEAFKALFAERQSSVASKINQNVADTSPHRFTIYRSKDNGLVFVGLSIHHALFDGISLSHILRNLEKVYLDEPGYPSAAPEAVLDTIASVNVQTAQDFWVQHFAGFDWNRMPSRTASAKRADEKSLTFQIGLSELQRKASERRITLQSLLMTAFAHFLAKYMYGHNDVAFGIIRSGRSLPIADIETTVLPLLSVLPARVVLSASDVLRNVQTFNAEVTAYEHIPLGKIQQWVRPGANLFETLFSLSYKDDGRSSVWRLLESHNPEPDYILAVEVVLDTTEDRLTVQVAYTSQDLSSDIVDHLLDNFEGLALDLAQGSALNVETDSAAESGTALTSSEQTTQVTDIDAGEIDAVDEDLLLRLRKIVANFLQISVDLVTEGVSLVALGLDSIRSVGLSRVLRKEGIELASAEIMKLATPRRMAASAGKKISIPSTTKHKIDAYASSFARERDRIRAALDAASVSLSPDDEVDVFPVTTLQAGMLSQTVSSAGRRYVHLFPLRLTNGVDVAKLRDAWAKTVDALGILRTTFHFVPDLGIWTSAVHSKSPLKWSEIYLLEDASLLPLLDAVTITDAGCNSPPYQLYLVRSQEVDSQEDCRLIMVLHHALYDGVSISKLLDIVGASYNGEVTQNIVQFTSLLPEILWQEHLGTSFWVERLKNFHHGLVVPRLPDGSHSKKSHVASSVLNVSRSEVEKVCRLTAVTTQCVGQYAFAKLLASLTRSTDILFGHVVSGRNVSGAEDVIGPVLNTVPCRVRFASSVSNKLLLQAIHDTNVTALSWQHASLRSIQSHLKVERLWDCLFVFQPSQATETSEHKSVWEFDEVEDEDIDIQYGFNLELHETAAGFLLKAACSDRLMDAEDLGAALERFGLFLRVLVDDLDASCLNGLPDLTAPTTPHSVSESDFETDQIVSSWDEKSSTLRELLSTATGIPSSKIQMSMRLLGLGIDSISAIQIASKARRTGLHLTARDIIQSRTVGDLVMRAGAEDESEDRAGQALQTAFQIPRQEWSALTPKVKESDVDSVTVATPGMQWFMGGWQRSGGSRYQHVFGFELSADVDILKLQKAWDELLTRHAILRAAFSSSAQGEPRVVIYKRESMGARWQEEECDDIQDYDEGVASRMRALISSPPSSMQEPLTRATLLRSPSRNALIIHLHHFQYDAWSLQLLLDDLVRLYQGQPPTSSNDHSAILRVAVPDEHTRTEQRSYWQRMLTPNDPTLILFPKIPGHQARSNSSHNFLMKKSVLTPIADLEARARALSVSLYVVYLTCWAQVQAAATSSNSAIFGLWHSGRTGSIDQVECLAAPCLNILPFVVRGFNSTSTMDIATQIQDDLRERTPLVEQSPLTLVDEVMGGTGRPLCNVFVNIVRAAPELHSTQQTIFTPIDVPYFIPEAPSRGKTAMPELKVTGLIQDDIIVDIVDVSERGEVAMSIEFSEDTLDVETAEAMILQWVQLVKECLA
What is the function of this protein?
Nonribosomal peptide synthase; part of the siderophore basidioferrin biosynthetic pathway (PubMed:28842536).  The biosynthesis of basidioferrin depends on the hydroxylation of ornithine to N(5)-hydroxyornithine, catalyzed by the monooxygenase SMO1 (PubMed:28842536).  The second step, the acylation of N(5)-hydroxy-L-ornithine is catalyzed by a not yet identified N-acyltransferase (PubMed:22434909).  Finally, assembly of basidioferrin is catalyzed by the nonribosomal peptide synthase (NRPS) NPS2 via amide bond formation between three L-AHO molecules to release the linear L-AHO trimer (PubMed:22434909).  N-5-acetyl-N-5-hydroxy-L-ornithine (L-AHO) and N-5-cis-anhydromevalonyl-N-5-hydroxy-L-ornithine (L-AMHO) are accepted as the substrates by the NPS2 adenylation (A) domain, but only L-AHO is trimerized (PubMed:28842536).
What are the official names of this protein?
Nonribosomal peptide synthase NPS2, NPS2, NRPS 2, Type VI siderophore synthetase NPS2.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.