PharMolix/UniProtQA huggingface dataset:
Protein: VPR_HV1MN
Sequence: MEQAPEDQGPQREPYNQWALELLEELKNEAVRHFPRIWLHGLGQHIYETYGDTWAGVEAIIRILQQLLFIHFRIGCRHSRIGIIRQRRARNGASRS
What is the function of this protein?
During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus.  This function is crucial for viral infection of non-dividing macrophages.  May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.
What are the official names of this protein?
Protein Vpr, R ORF protein, Viral protein R.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPR protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host extracellular space. Note=Incorporation into virion is dependent on p6 GAG sequences. Lacks a canonical nuclear localization signal, thus import into nucleus may function independently of the human importin pathway. Detected in high quantity in the serum and cerebrospinal fluid of AIDS patient.
Protein: Y845_CHLTE
Sequence: MKHVDTEIPTEEQIHEAEKFGFHGQVQAAKIRFDRYFPGVLASITVAAAATFLSDHYGAPTMLFALLIGMAFRFLSEDESRALVGIQFASTTVLRIGVALLGMRITLGQIQSLGVKPVVMVFFSVLLTILFGLALSKMMGRGKRFGVLTGGSVGICGASAALAIAAVLPQDEYSERNTIFTVISITALSTLAMIAYPVVAQWFGLDHQAAGIFLGGTIHDVAQVVGAGYSVSEQTGDTATVIKLLRVSMLVPVVFILSLIFHKRNQKDGNAPRRTLLPPFIIFFVLFVGINSLGVVPKPATQFINDVSRWCLVTAIGALGMKTSLKSLFEVGWKPVSIMIAETVFLAVLVLGSVVWMS
What are the official names of this protein?
UPF0324 membrane protein CT0845.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: STP2_HUMAN
Sequence: MDTQTHSLPITHTQLHSNSQPQSRTCTRHCQTFSQSCRQSHRGSRSQSSSQSPASHRNPTGAHSSSGHQSQSPNTSPPPKRHKKTMNSHHSPMRPTILHCRCPKNRKNLEGKLKKKKMAKRIQQVYKTKTRSSGWKSN
What is the function of this protein?
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals.  In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
What are the official names of this protein?
Nuclear transition protein 2, TP-2, TP2.
What is the protein family that this protein belongs to?
Belongs to the nuclear transition protein 2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Chromosome. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated (By similarity).
Protein: RAP1B_PONAB
Sequence: MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQLL
What is the function of this protein?
GTP-binding protein that possesses intrinsic GTPase activity.  Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen.  Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.  Plays a role in the establishment of basal endothelial barrier function (By similarity).
What are the official names of this protein?
Ras-related protein Rap-1b.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol (By similarity). Presence of KRIT1 and CDH5 is required for its localization to the cell junction (By similarity).
Protein: RNH2_BACAH
Sequence: MQKVTIQEAEHLLQEIMSEEDDRFQILIKDERKGVQKLILKWYKQKELAQKEKEKFLEMSKYENALREKGLTYIAGIDEVGRGPLAGPVVTAAVILPEDFYIPGLNDSKKLSEAKRERFYGEIKAKAIAIGVGIVSPQVIDEINIYQATKQAMLDAIANLSCTPEYLLIDAMKLPTPIPQTSIIKGDAKSISISAASIIAKVTRDRMMKELGEKYPAYGFEQHMGYGTKQHLEAIEAHGVLEEHRKSFAPIKDMIQK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_RHOPB
Sequence: MLSYDSVAVLGGGAWGTALAQTGARAGRDVVLWEHDANNAQQLQQKRESLYLPGVTLDSSIKVTRDLSEAARAQAILLVVPAQVLRQVVTSLAPLIADRTPLVACAKGIEHGTHKFMTEIIAEAAPQATPAILSGPSFAADVARGLPTAVTIAATDAGIAQALAQAMNSGTFRPYHSTDVRGVELGGATKNVLAIAAGIVEGRKLGASALAAMTTRGFVELMRFGKAYGARIETMHGLSGLGDLTMCCSTPQSRNFSFGVALGRGESASEASHGKLAEGAFTAPVLLEMARLKNVEMPISTAVAAILAGQISVDAAIESLLTRPLKAEE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFB_BURTA
Sequence: MTKSELVAQLASRFPQLVLKDADFAVKTMLDAMSDALSKGHRIEIRGFGSFGLNRRPARVGRNPKSGEKVQVPEKHVPHFKPGKELRERVDGRAGEPLKNDEPEDGQ
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: CBIH_PRIMG
Sequence: MKGKLLVIGFGPGSFEHITQRAREAIQESDMIIGYKTYVELIQGLLTNQQIISTGMTEEVSRAQEAVKQAEAGKTVAVISSGDAGVYGMAGLVYEVLIEKGWKKETGVELEVIPGISAINSCASLLGAPVMHDACTISLSDHLTPWELIEKRIEAAAQADFVVAFYNPKSGRRTRQIVEAQRILLKYRSPDTPVGLVKSAYRDREEVVMTNLKDMLNHEIGMLTTVVVGNSSTFFYDDLMITPRGYQRKYTLNQTEQPLRPHQRLRKEAEPWALDQEEAVKQSASAIEAVQNTREETAASRALAEEALQAILGESTSAVVHQPIESIFEVAVSPGLANKKFTPVQMTTLAEVVGEKGTMEYTPDHQIKLQIPTAHPDMIIEKLQAASFLLSPVGDVFTIKACDFCDGEKSDAIPHTEELQKRLGGMDMPKELKLGINGCGMACYGAVQEDIGIVYRKGAFDLFLGAKTVGRNAHSGQIVAEGIAPDDIVEIVENIIHEYKEKGHPNERFHKFFKRVKNVYGFDYQDITPKIKVEPAPCGD
What is the function of this protein?
Methyltransferase that catalyzes the reduction, ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-precorrin-4.  Is also able to convert cobalt-precorrin-3 to cobalt-precorrin-4.
What are the official names of this protein?
Cobalt-factor III methyltransferase, Cobalt-precorrin-3 methylase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the precorrin methyltransferase family.
Protein: HIS4_SYNS9
Sequence: MEIIPAIDLLDGACVRLHQGDYDQVTRFSDDPVAQALSWQSQGAKRLHLVDLDGAKRGEPANDAAVRAIANALDIPVQLGGGVRSIERAEDLLNCGLERVILGTVAIEQPDLVQVLAERHPGSVVVGIDANKGKVATRGWLEQSDVLATDLARRFSDSGIAAIITTDIATDGTLAGPNLDALREMAQASSVPVIASGGIGCMADLLSLLPLEDQGVSGVIVGRALYDGRIDLAEAIGAIGDDRLQDITCGSTDLA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP2SB_BACAN
Sequence: MLYNINKRLYLFEKGREEMAEVNVKKSSFFKEKKEVPNTDFSLLKGALIQNLDRLEKFVEAIPYKYIKEGNVKENA
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Antitoxin that binds toxin SpoIISA and neutralizes its toxic activity (By similarity).
What are the official names of this protein?
Stage II sporulation protein SB, Antidote protein SpoIISB, Antitoxin SpoIISB.
What is the protein family that this protein belongs to?
Belongs to the SpoIISB antitoxin family.
Protein: EFG_BACC3
Sequence: MAREFSLENTRNIGIMAHIDAGKTTATERILYYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKGHRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTIHDRLQANAHPIQLPIGAEDEFNGIIDLVEECAYMYGNDLGTDIQRVEIPEEHKELAEEYRGKLIEAVAELDEEMMMKYLEGEEITVEELKAGIRKATTSVEFFPVICGSAFKNKGVQILLDAVIDYLPSPLDVPAIKGIVPDTDEEVERKSSDEEPFAALAFKIMTDPYVGKLTFFRVYSGVLNSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEKSLVILESMEFPEPVISVAIEPKSKADQDKMGTALSKLSEEDPTFRAHTDQETGQTIIAGMGELHLDIIVDRMRREFKVEANVGAPQVAYRETFRAAAKVEGKFARQSGGRGQFGHVWIEFEPNEEGKGFEFENKIVGGVVPREYIPAVGAGLEDALKNGVLAGYPVVDIKAALVDGSYHDVDSSEMAFKIAASMALKAAVSKCNPVILEPMMKVEVVIPEEYMGDIMGDVTSRRGRVEGMEARGNAQVVRAMVPLSEMFGYATSLRSNTQGRGTFSMVFDHYEEVPKSVSEEIIKKNKGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3995_MYCS2
Sequence: MTVPVNATNLRIPLDTGRDREFLDSWAELEAIGATPAGGVERQAGTAEDGQMRDWLSRWLRTRGFSVEVDPIGNLFGLLEFNPGAPYVLVGSHLDSQPRGGRFDGAYGVLAGAVAADRTRRYVTRSGFTPRYNVAVVDWFNEEGSRFKPSMMGSAVFTGTLDLEEALNTTDDDGVSVRDALAAINGIGDREVFSSTGPRQLAAYAEIHIEQGRELEKNNVTIGLVDRTWAANKYELNVVGIQGHTGATAIEDRQDALLGAALIVVALRDIADEFGEELHTSCGQLTVLPNSPVVVPREVHMHLDLRSDNDELLAAADAALRRRIAEAEIRAGVKVEHRKAHVWPGHHYQPQGVELARDAANDLGISSMLVQTRAGHDSTNMKEIVPSVMLFVPSVEGISHAEAEYTSDEDLCSGVDLLTEVVARMLDGSLDAAGAGHP
What are the official names of this protein?
Putative hydrolase MSMEG_3995/MSMEI_3903.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20 family.
Protein: CH10_PSEPF
Sequence: MKLRPLHDRVVIRRSEEEKKTAGGIVLPGSAAEKANHGEILAVGPGKALESGEVRALSVKVGDKVVFGPYSGSNTVKVDGEDLLVMSENEILAVIEG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APTB_EMENI
Sequence: MAFRIPFAQDFWNEYLSGRENTIPTLPVVTDITERVIRVLGGNAGPMRLQGTNTYLVGTGRSRILVDTGQGMPSWIRDIAKVLEERDIDISYVLLTHWHGDHTGGVPDLIAYNPALSSRIYKNRPDAGQKDILDGQVFRVEGATLRAVHTPGHAADHMCFLFEEENALFTGDNVLGHGYSVVEDLGQYMNSMVQMANLNLPLGYPAHGAVIDDLPDKMREYIKHREFRVQQVYAILEESRAAGQGRGRGGLTLHEIILAMYGEITDEVEKALAPFLSQVLWKLAEDRKVGFEPGSAAKRRWYVRSRRPN
What is the function of this protein?
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of asperthecin, an anthraquinone pigment (PubMed:18978088, PubMed:21866960).  Polyketide synthase (PKS) aptA catalyzes the formation of the aromatic polyketide from acetyl coenzyme A and seven malonyl coenzyme A molecules (PubMed:18978088).  Polyketide is subsequently hydrolyzed by the action of aptB into endocrocin-9-anthrone (PubMed:18978088).  Endocrocin-9-anthrone is then oxidized into endocrocin by aptC (PubMed:18978088).  Endocrocin is likely to decarboxylate spontaneously to form emodin which explains why there is no decarboxylase in the asperthecin biosynthesis cluster (PubMed:18978088).  Finally, aptC or another endogenous oxygenase catalyzes additional oxidation steps to form asperthecin.
What are the official names of this protein?
Lactamase-like protein aptB, Asperthecin synthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.
Protein: YEET_ECOLI
Sequence: MKIITRGEAMRIHQQHPTSRLFPFCTGKYRWHGSAEAYTGREVQDIPGVLAVFAERRKDSFGPYVRLMSVTLN
What are the official names of this protein?
Uncharacterized protein YeeT.
What is the protein family that this protein belongs to?
Belongs to the YeeT/YkfH/YpjJ family.
Protein: ASSY_BORPE
Sequence: MTTILPNLPTGQKVGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEPDYDEIPRRAMQYGAEAARLVDCRAQLVAEGIAALQAGAFHISTAGLTYFNTTPIGRAVTGTMLVAAMKEDGVNIWGDGSTFKGNDIERFYRYGLLTNPDLKIYKPWLDQTFIDELGGRAEMSEYMRQAGFDYKMSAEKAYSTDSNMLGATHEAKDLELLSAGIRIVQPIMGVAFWQDSVQIKAEEVTVRFEEGQPVALNGVEYADPVELLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLFIAYERLVTGIHNEDTIEQYRENGRKLGRLLYQGRWFDPQAIMLRETAQRWVARAITGEVTLELRRGNDYSLLNTESANLTYAPERLSMEKVENAPFTPADRIGQLTMRNLDIVDTREKLFTYVKTGLLAPSAGSALPQIKDGKK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_BACC4
Sequence: MDNMNHEELNDQLIVRREKLHNLREQGIDPFGKRFERTNSTTDLVSLYGEFSKEELEEKEIAVSIAGRIMTKRGKGKAGFAHVQDLHGQVQIYVRKDAVGDDEYELFKTADLGDLVGIEGKVFKTNVGELSVKATGFTLLTKSLRPLPDKYHGLKDVEQRYRQRYLDLITSMESRETFVTRSKIIREMRRYLDDNGYLEVETPMMHAIAGGASARPFTTHHNALDMELYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYKDIMKLTEDMVAHIAKKVLGTTTIQYGDYEINLEPEWTRLHMVDAIKQYSGADFWNPMSVEEARELAKEHNVEIKDTMEVGHIINEFFEQKVEDKLIQPTFIYGHPVEISPLAKKNDEDPRFTDRFELFIVAREHANAFTELNDPIDQKERFEAQLKEREQGNDEAHMMDDDYIEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPAMRHKQD
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCR_ECO8A
Sequence: MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRGPGGGYLLGKDASSIAVGEVISAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGFLNNITLGELVNNQEVLDVSGRQHTHDAPRTRIQDAIDVKLRA
What is the function of this protein?
Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.
What are the official names of this protein?
HTH-type transcriptional regulator IscR.
Protein: MNME_BRADU
Sequence: MHPRDQTIFALSSGRPPSAIAVVRVSGAQAGLVLTTLAGKLPAPRQASRRLLRDGTGQPIDDAVVLWFPGPASATGEDVAEFHAHGGRAVLAALLAAISVIPNMRAAEPGEFTRRAFENGKLDLTEAEGLDDLIHADTDRQRRQALRQLQGLLGNRARDWRERIIEASALIEAGIDFSDEGDVPAELRAPAVKAIKALHVEITEVLAAQGHSERLRDGMVVAIAGEPNVGKSTLMNQLARRDVAIVSPHAGTTRDVIEVQLDLDGYPVTVIDTAGIRETDDPVEQEGVRRARARAEDADLVLWLVEGEQAADPASMRSLWTSGDGSHPSGGSVWIVRNKIDLGEFGDEGPQGEFGISASRGDGIRELVDALVKFSAEFFGTSEGALVTRARQRDLLRQASDSLRRSLELVGEGEELAAEELRSAAYALGRLLGRVDVEDVLGAIFQKFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOF1_CANAL
Sequence: MSDYESGSDIDNYYEADEFDDFIEYSDNEVEQEKSKPTPGQIEVEEIEEPEEDRIRTLTTTLKPNETQAQKLLKAHISVLVSALGGPDHTSDIQPPPYKLGHDALACLKDIKRWIRAVDEKKNNYEVALACAESGLVTNDLIVIMCQWEDKMQKKEIIKNKTTTEKTMLACLELLVLLTWPVEFGKDLSESQKLLYSEIKKVHVSYKKQILMFNNGQLLKAAIRLVLPTIAKSRIDREPRDNQILKLVLYLIRNLLAIEPANLSISNKSRKGASVTASDLPLGVTQDDISINNVLSVFKKNKVLMLLLTISGSLGTEFDRDMFGEICLESIYLIIKGLSASEVLVKKNLGSTPVAAPSQNTVPDAINASQPLQPVTTTVGMQLQDLLATESKKKKIQTQNIASRHGRFGSLLSIRSADSNSFVVSGQEALINTDSSLAKLDKSKKWKDRTYFKYDSDEYVNTSTPVYLNLTGQDILYNFVEQFLSGGCFNNLIECMGSRLTSQTDLNMVDELTLASYFFTISWFLSYQRERIGLDSENKELNYGSVGAALSEVNFILIIGYFRDSFSVKKWNSLHVAMICFKELLQISNSVFGKEITNQTGEGDEISQHEIDRELAEGIIRKLFSFNDFLSIIVQIPQTAAKHSPDYLRVSVSVVHILLKAFETFANEDVHLYIQSKRKQSKRNRKRVNNLDKSTEDRLRDVIYASDEELDQSSAKEITQERKLDFKKTEARFFHQAIVSTYINYLSRYEDLSNQEIKTCLSYFHRLFVVRKDFTGLYRLDFMQLLQKLRNYLQRGSSLRLQVEEFIYYFMKKFKTAFERFPMPIEVLFPRFEDNECKVYLATGEVYEKEETTSTSRSPRLAKDLEFVRDFGLDDQIKILVSQLHVQEKQSLLKWLIQELERIINDRILNSDSIAELNASNQQRRLFINNGYLRFLLRIIGFDLPYTMEEVPELATTVDMEHLTKVTELIKKWDSSQPVIFEDDKVPSYFVRTREAGYDEDQYNENDQEYDFNDDSIAFETEANPNSNRNHVSELDHLEELERQLSSNGSRVNSKERNGTKGKARKKSKEKKRPEPKKVRGLKRRRIPKDLLDDDDSQHVVKSAEFVHDSDDESDDEKDKAFFEREEKMRNLLNDMGGIATSEQLKEIQKVWKNLETGGNNKVASTVAKAVKEVGLFVEESDNDDEVEEESRNSAPVNEEADRTIFESGEVDTQQDLSDNTSNTSDMESETETTKRSFVEDPEEISHVQPKRKRLVISDDEEE
What is the function of this protein?
Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair.  FPC coordinates leading and lagging strand synthesis and moves with the replication fork.  FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
What are the official names of this protein?
Topoisomerase 1-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the timeless family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GUAC_YERPB
Sequence: MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTFRMAEVLASFDILTAVHKHYTLEQWAEFVKRSPESVLRHVMVSTGTSSADFDKMKQILALSPSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVVTGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVMLGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGSVDNTVRDIMGGLRSACTYVGASHLKELTKRTTFIRVAEQENRVFGTD
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Protein: CH10_DESPS
Sequence: MKIRPLNDRLLVKRLAEEEKTAGGIIIPDSAKEKPAEGQVVAVGPGKVSDSGERVALQVKEGDLVLFSKYGGTDVKLDGEDFLIMREDDILGIME
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDS1_PITNO
Sequence: LLGMLPVALSALSALSKL
What is the function of this protein?
Antimicrobial peptide with very low activity against Leishmania species (L. amazonensis and L. infantum) (PubMed:23774944).  Shows low cytotoxicity against mammalian cells in models of peritoneal macrophages (PubMed:23774944).
What are the official names of this protein?
Medusin-N1, MDS-N1, Phylloseptin-S1, PLS-S1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Medusin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PURL_CERS4
Sequence: MTEPEITPELIAAHGLKPDEYQRILEIIGRAPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTTGPQVICGPGENAGVVDIGDGQAVIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALSFGVPDHPKTAHIVKGVVEGIGGYGNAFGVPTVGGEVRFHRAYNGNCLVNAFAAGLADADRIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVGDPFTEKRLLEACLELMASDSVISIQDMGAAGLTCSAVEMGDKGDLGIRLQLDAVPQREANMTAYEMMLSESQERMLMVLKPEKEAVARAIFEKWDLDFAIVGETIPEDRFLILHGNEVKADLPLKALSGTAPEYDRPWIETPAAAPLGAVPEVDPIEGLKALIGSPSYAHKAWVWEQYDSQVMADTVRAPGLGAGVVRVHGTPKALAFTSDVTPRYVKANPFEGGKQAVAEAYRNLTAVGAKPLATTDNMNFGNPEKPEIMGQFVGAIKGIGAAVAALDMPIVSGNVSLYNETDGVGILPTPTIGAVGLLTSLDELIAGQPEEGDLALVIGTTAGHLGQSALLAEMFGREEGDAPPVDLEAEKRHGEFLRANRKLVRAAADLSDGGLALAAFEMAEAAGLGLTLTPSGTAALFGEDQARYLVACAPDRAEALQAAAEAAGVPLQEVGRFGGATVTLAGASAPLADLSRLYRRAFAEAIGG
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLA_ARTBC
Sequence: MLLYYILVALWATVTYAKSFSEDISEMPELSEMSSYLNQTPEAKDVLDQQKNVTLLALENSAFRDFVGQGEGNDNQSSSNSSLLRGIFSYQLVKGLHNSEQITTTPQFSPTELNDAGFTNVSSGQIVQLVEKDGKDYAISGLNDNSTIIKPGVDVENGVIHVIDRPLTLPQSVTATLQAANLTSFQGALQRGNAVSNANDPKDITLFAPRNLGFQRIGTAFENISAEDLGQIANYHIVKGKVLYSPDLTDADHPTYADKDLHISTVDGRSYVNSARVESTNLLVNNGVIHVISDVLNPNNDTAKPVPNADPPPPAFENANPVSTDPLTDGIPSPTSVIPLPGITSGGEGGGGGGGESTAPPSPTATVTETQSGGGGGGGGGAGGGPGPTATNTPQPGAAATERAKAGLAAVVGLGVVLINA
What is the function of this protein?
May be a cell surface adhesion protein.
What are the official names of this protein?
Fasciclin-like arabinogalactan protein ARB_02922.
What is the protein family that this protein belongs to?
Belongs to the fasciclin-like AGP family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: ADRB2_CANLF
Sequence: MGQPANRSVFLLAPNGSHAPDQGDSQERSEAWVVGMGIVMSLIVLAIVFGNVLVITAIARFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAKETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQLQKIDRSEGRFHAQNLSQVEQDGRSGHGHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSNNSNSRSDYAGEHSGCHLGQEKDSELLCEDPPGTEDRQGTVPSDSVDSQGRNCSTNDSLL
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
What are the official names of this protein?
Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Golgi apparatus. Note=Colocalizes with VHL at the cell membrane. Activated receptors are internalized into endosomes prior to their degradation in lysosomes. Activated receptors are also detected within the Golgi apparatus.
Protein: RN141_DANRE
Sequence: MGQQLSGQAVTRLPEKLIKHVGLVRDSGYLTYDEFLGRVAELNDVTAKLASGQKKHLLFEVQPGSDSSALWKVAVRIVCTKINKEDGMVEASRIMNLYQFIQLYKDITSQAAEVFSSNVAAEGSSEDTCQASMWMGRVKQLTDEEECCICMDGKADLILPCAHSFCQKCIDKWSGQSRNCPVCRIQVTAANESWVMSDAPTGEDVAGYILNLADEAGHPHRP
What are the official names of this protein?
RING finger protein 141.