PharMolix/UniProtQA huggingface dataset:
Protein: HAUS5_HUMAN
Sequence: MELAQEARELGCWAVEEMGVPVAARAPESTLRRLCLGQGADIWAYILQHVHSQRTVKKIRGNLLWYGHQDSPQVRRKLELEAAVTRLRAEIQELDQSLELMERDTEAQDTAMEQARQHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQLRRLQDMERKAKVDVTFGSLTSAALGLEPVVLRDVRTACTLRAQFLQNLLLPQAKRGSLPTPHDDHFGTSYQQWLSSVETLLTNHPPGHVLAALEHLAAEREAEIRSLCSGDGLGDTEISRPQAPDQSDSSQTLPSMVHLIQEGWRTVGVLVSQRSTLLKERQVLTQRLQGLVEEVERRVLGSSERQVLILGLRRCCLWTELKALHDQSQELQDAAGHRQLLLRELQAKQQRILHWRQLVEETQEQVRLLIKGNSASKTRLCRSPGEVLALVQRKVVPTFEAVAPQSRELLRCLEEEVRHLPHILLGTLLRHRPGELKPLPTVLPSIHQLHPASPRGSSFIALSHKLGLPPGKASELLLPAAASLRQDLLLLQDQRSLWCWDLLHMKTSLPPGLPTQELLQIQASQEKQQKENLGQALKRLEKLLKQALERIPELQGIVGDWWEQPGQAALSEELCQGLSLPQWRLRWVQAQGALQKLCS
What is the function of this protein?
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
What are the official names of this protein?
HAUS augmin-like complex subunit 5.
What is the protein family that this protein belongs to?
Belongs to the HAUS5 family.
Protein: HISX_PSE14
Sequence: MTTPTAIRRLDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDEALVEFTQKFDGLQVASMADLILPRERLELALTRITPVQREALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEINELVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQVGIDMIAGPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDADFLDKVAASITRLLPTMERAAIVETSINGRGALIKVADMAQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRHTSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIYCSPQGASELGKTASVLARGESLSGHARSAEYRITDPDWKAGNTEDGK
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: Y095_AFV1Y
Sequence: MGNETGKETSGKEQDKVKDVIIRLVEEDGRIAVYLVQGLNTEFLGYADEIQLAKEIAKLNKFISIWRLNPLDHRLRDYLRQEIIERLVRVMAYMM
What are the official names of this protein?
Uncharacterized protein ORF95.
Protein: RAD25_HALSA
Sequence: MTDISKDRFLDALEGVGRPVATAEQIARELDCTQATAADALAALAADDEVERANVEPDPVVWYPRDWLELTDRERIVPFPDRREIIVDQPSQLTRAQLSRVAHLTDTTRTGSYRYEVRAEDVWAAPFDSLSDLVAAITELLPRDCPTLIEWVREQWTRATRFRLRTHDDGYVVLEAATDSLLGNVAEQKLDDDVLRAPISDTEAWVAAEQVAPLKRTLYEAGYPVRDDRDLESGEPLAVDLHLDLRPYQQDWVDRFEDASAGVLVGPPGSGKTVAAMGALESVGGETLVLVPSRELATQWREELLANTSLTGDQIGEYHGGEKRVRPVTIATYQTAGMDRHRHVFDDREWGLIVYDEVHHIPAEVARRSASLQSKHRLGLTATPVREDDKEADIYTLVGRPIGTDWDALFDAGFVAEPEVEIRYVPWRDDDDRYEYAAASGHTRRRLAAENPAKEAEIEHLVDQHGDTQALVFVDYLSQGERIAERLDAPFVNGETPHSRRETHFDQFRTGALDALVVSRIGDEGIDLPDAEFAVVASGLGGSRRQGAQRAGRTMRPGSQSLLFVLATRGTEEEDHARSRMRHLSTKGVRVTESDASHSP
What are the official names of this protein?
Putative DNA helicase Rad25.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RAD25/XPB subfamily.
Protein: TRA1_COXBU
Sequence: MDPPLKDGVIMRQHRISIFKKRRRSMKDIKILGVDIAKDVFQLCGIDEWGKVIYTRRVKRAQYVSTVASLKVGCVVMEACGGANHWYRTFMGMGIPTQLISPQHVKPYVKSNKNDRNDAQAIAEAASRASMRFVQGKTVEQQDVQALLKIRDRLVKSRTALINEIRGLLQEYGLTMARGAKRFYEELPLILASEAVGLTPRMKRVLNCLYTELLNRDEAIGDYEEELKAVAKANEDCQRVQSIPGVGYLTALSVYASVGDIHQFHRSRQLSAFIGLVPRQHSSGNKEVLLGISKRGNVMLRTLLIHGARALLRHVKNKTDKKSLWLKALIERRGMNRACVALANKNAPIIWALLTRQETYRCGA
What is the function of this protein?
Required for the transposition of the insertion element.
What are the official names of this protein?
Transposase for insertion sequence element IS1111A.
What is the protein family that this protein belongs to?
Belongs to the transposase IS1111A/IS1328/IS1533 family.
Protein: ATPF3_BEII9
Sequence: MHIDWWTLGLQAINVLILIWILSRFLFKPVAAIVEARRASIARLLDEAHATRVAAEAEREKARQEVTSLATARAAALQKAEDEAKAETETILANARSEAGKLREAAKADIARARQDEAAAMADHASQLAVDIAGKLLSRLPEEARISGFIEGLAQGLAALPEAIRTNIGATDAPVQLKAARALTEAETQACRVRLSEALGHPAEIAVDVRPELIAGLEIDMPHAVVRNSFRADLTRITAALIQTGSMQTGQEAPRPETP
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b 3, ATP synthase F(0) sector subunit b 3, ATPase subunit I 3, F-type ATPase subunit b 3, F-ATPase subunit b 3.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL3_PSYIN
Sequence: MTIGLIGRKVGMTRVFTEDGVSIPVTVLECSPNRVTQVKTLDTDGYQALQVTAGSKKASRVNKPEAGHFAKAGVEAGRGLWEFTLADNEGADIKVGAELSVELFNEINKVDVTGQSKGKGFQGAIKRWNFSMQDATHGNSVSHRAPGSIGQCQTPGRVFKGKKMAGHMGAERVTTQNLEVVRVDIERNLLLVKGAVAGAKNGDVIIKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RR6_GUITH
Sequence: MTKLNSYETLYIVKPELTEDSLAKLIESYQGLLLERGAKNIITQNRGRRTLKYMIKKYKDAHYVQMNYEGNGEVIQLLERAMKINESIVRFLTTAI
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRMA_MUSP7
Sequence: MTPSTLPIDQYDAQLAEKTGRLKAMMASYHAPEPQVFRSPVSHYRMRAEFRIWHDGDDLYHIMFDQQTKHRIRVDQFPVASELINRLMPALLNALRPHLTLRRKLFQIDYLSTMSNEIVVSLLYHKTLDDEWRQQAIALRDQLRQQGFNLQLIGRATKTKICLDHDYVDECLPVAGKQMVYRQVENSFTQPNAAMNIQMLEWALSVTEGSKGDLLELYCGNGNFSLALARNFERVLATEIAKPSVQAAQYNITANQIGNVQIIRMAAEEFTQAMRGVRQFNRLEGIDLASYRCDTIFVDPPRSGLDEETVRLVQEYPRILYISCNPETLCANLATLTQTHRVSQLALFDQFPYTHHMECGVLLEKRT
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: PTPA_STAES
Sequence: MIHVAFVCLGNICRSPMAEAIMRQRLQERGISDIKVHSRGTGRWNLGEPPHNGTQKILQKYHIPYDGMVSELFEPDDDFDYIIAMDQSNVDNIKQINPNLQGQLFKLLEFSNMEESDVPDPYYTNNFEGVFEMVQSSCDNLIDYIVKDANLKER
What is the function of this protein?
Dephosphorylates the phosphotyrosine-containing proteins.
What are the official names of this protein?
Low molecular weight protein-tyrosine-phosphatase PtpA, Phosphotyrosine phosphatase A, PTPase A.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Protein: LPXB_ALIF1
Sequence: MTKPLRIGIVAGELSGDTLGEGFIKSIKAQYPDAEFVGIGGPKMIAQGCDSLFDMEELAVMGLVEVLGRLPRLLKVKAELVRYFTQNPPDVFIGIDAPDFNLRLEKTLKDNGIKTVHYVSPSVWAWRPKRIFKIDAATDLVLAFLPFEKAFYDKYNVACEFIGHTLADAIPMETDKIAARDLLGLEQEREWLAVLPGSRGGEVALIAKPFIETCQRIHKQHPNMGFVVAAVNEKRREQFETIWKATAPELDFVIIQDTARNVMTAADAVLLASGTVALECMLVKRPMVVGYQVNKLTGWIAQKLSITEFVSLPNVLAGKELVQEFIQEECHPDFLYPAMEKVLNNDNRELIEKFTEMHQWIRKDADKQAANAVLRLINKETAE
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: VP2_BTV1S
Sequence: MDELGIPVYKRGFPEHLLRGYEFIIDVGTKIESVGGRHDVTKIPEMNAYDIKQESIRTALWYNPIRNDGFVLPRVLDITLRGYDERRAVVESTRHKSFHTNDQWVQWMMKDSMDAQPLKVGLDTQVWNVAHSLHNSVVEIDSKKADTMAYHVEPIEDASKGCLHTRTMMWNHLVRIETFHAAQEVHILFKPTYDIVVHAERRDRSQPFRPGDQTLINFGRGQKVAMNHNSYDKMVEGLTHLVIRGKTPEVIRDDIASLDEICNRWIQSRHDPGEIKAYELCKYLSTIGRKSLDREKEPEDEANLSIRFQEAIDNKFRQHDPERLKIFEHRNQRRDEDRFYILLMIAGSDTFNTRVWWSNPYPCLRRKLIASETKLGDVYSMMRSWYDWSVRPTYAPYEKTREQEKYIYGRVNLFDFVAEPGIKIIHWEYKLNHSTREITYAQGNPCDYYPEDDDVIVTKFDDVAYGQMINEMINGGWNQEQFKMHKILKSEGNVLTIDFEKDAKLTTNEGVTMPEYFNKWIIAPMFNAKLRIKHEEIAQRQSDDPMVKRTLSPIAADPIVLQRLTLARFYDIRPALIGQGLSRQQAQSTYDEEISKQAGYAEILKRRGIVQIPKKPCPTVTAQYTLELYSLSLINILQQHVARDCDEEAIYEHPKADYELEIFGESIVDISQVIVLVFDLIFERRRRVRDVYESRYIITRIRRMRGKERLNVIAEFFPTYGSLLNGLNSAYVVQDIMYLNFLPLYFLAGDNMIYSHRQWSIPLLLYTHEVMVIPLEVGSYNDRCGLIAYLEYMVFFPSKAIRLSKLNEAHAKIAREMLKYYANTTVYDGGDNSNVVTTKQLLYETYLASLCGGFLDGIVWYLPITHPKKCIVAIEVSDERVPASIRAGRIRLRFPLSSRHLKGSAIIQIDLVGRFTVYSEGIVSFLVCKKNLLKYKCEIILLKFSGHVFGNDEMLTKLLNV
What is the function of this protein?
The VP2 protein is one of the two proteins (with VP5) target of the host immunogenic response.  Responsible for viral which constitute the virus particle outer capsid.  It is the major attachment to target host cell, probably by binding to sialic acid.  This attachment induces virion internalization predominantly through clathrin-dependent endocytosis.
What are the official names of this protein?
Outer capsid protein VP2.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP2 family.
What are the subcellular locations of this protein?
Virion.
Protein: PROA_METC4
Sequence: MPVLNLKSDLADADDLETLMAGIGRRARAAGRAMALAPAQTKDLGLRAIAEQIRTSAPAILRENARDVSAAQAAGLTNAIIDRLTLDEGRVAAIAEAVEKVAGLADPVGRQLAAFERPNGLLIERISVPLGVVGVIFESRPNVTADAGALCLKAGNAAILRAGSDSHRTATAIAAAMSEGLARAGLPADAIQLVPTRDRAAVGLMLTGLGGCVDVIVPRGGRSLVERVQAEAKVPVFAHLDGICHVYVAEGADLGMARSLLLNSKMRRTGICGAAETLLVDAAVAETHLKPLVEALLESGCAVRGDAATQAADPRVSAATDADWRTEYLDAIISAKVVDGLDAAIAHIEANGSHHTDAIITDDTNAAARFLNEVDSAIVTHNASTQFADGGEFGFGAEIGIATGRMHARGPVGVEQLTTFKYRVHGSGQTRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCAP_I74A2
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVVPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMENARPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: SF3B3_HUMAN
Sequence: MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEVSKKLEDIRTRYAF
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166).  SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.  Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).  May also be involved in the assembly of the 'E' complex (PubMed:10882114).  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077) (Probable).
What are the official names of this protein?
Splicing factor 3B subunit 3, Pre-mRNA-splicing factor SF3b 130 kDa subunit, SF3b130, STAF130, Spliceosome-associated protein 130, SAP 130.
What is the protein family that this protein belongs to?
Belongs to the RSE1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TGL_BACCR
Sequence: MIVIGRSIVHPYITNEYEPFAAEKQQILSIMAGNQEVYSFRTADELSFDLNLRVNIIISALELFQSGFQFRTFQQSFCNPQYWKRTSLGGFELLPNIPPSIAIQDIFKNGKLYGTECATAMIIIFYKALLSLYEEETFNRLFANLLLYTWDYDQDLRLITKNGGDLVPGDLVYFKNPQVNPATIEWQGENTIYLGNFFFYGHGVGVKTKEEIIYSLNERRVPYAFISAFLTDTITRIDSRIMSQYASSSTPQTSISFIPIRDDAIVATVGHTTTIY
What is the function of this protein?
Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links.
What are the official names of this protein?
Protein-glutamine gamma-glutamyltransferase, Transglutaminase, TGase.
What is the protein family that this protein belongs to?
Belongs to the bacillus TGase family.
Protein: AZOR_STAAB
Sequence: MAKVLYITAHPFNELVSNSMAAGKAFIETYQQQHPDDEVKHIDLFETYIPVIDKDVLTGWGKMSNGETLTDDEQMKVSRLSDILEEFLSADKYVFVTPMWNLSFPPVVKAYIDAISIAGKTFKYSAEGPQGLLTDKKVLHIQSRGGYYTEGPAANFEMGDRYLRTIMTFLGVPSYETIIIEGHNAEPHKTEEIKATSINNAEKLATTF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: GLMM_SALTI
Sequence: MSNRKYFGTDGIRGRVGNAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSASFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDDVEEAIEAEMEKEITCVDSAELGKASRIVDAAGRYIEFCKGTFPNELSLNGLKVVVDCANGATYHIAPNVLRELGATVIAIGCEPNGVNINEEVGATDVRALQARVLAEKADLGIALDGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKLQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMVRNHMSLHDLCSGMKMFPQILVNVRYTAGSGDPLENEAVKAVTADVEATLGNRGRVLLRKSGTEPLIRVMVEGEDEAQVTAFAHRIADAVKAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: AAAT_ECOLI
Sequence: MSEIVIRHAETRDYEAIRQIHAQPEVYCNTLQVPHPSDHMWQERLADRPGIKQLVACIDGDVVGHLTIDVQQRPRRSHVADFGICVDSRWKNRGVASALMREMIEMCDNWLRVDRIELTVFVDNAPAIKVYKKYGFEIEGTGKKYALRNGEYVDAYYMARVK
What is the function of this protein?
Catalyzes the N-acetylation of L-phenylalanine and L-methionine using acetyl-CoA as acetyl donor in vitro.  Cannot accept L-tyrosine as substrate and propionyl-CoA, succinyl-CoA or (S)-methylmalonyl-CoA as acyl donors (PubMed:27941785).  Is also able to acetylate and thus detoxify several nonhydrolyzable aminoacyl adenylates, but not the processed form of the peptide-nucleotide antibiotic microcin C (McC).  When overproduced, provides complete resistance to leucyl sulfamoyl adenylate (LSA) and partial resistance to alanyl sulfamoyl adenylate (ASA) and phenylalanyl sulfamoyl adenylate (FSA).  Therefore, may protect bacteria from various toxic aminoacyl nucleotides, either exogenous or those generated inside the cell during normal metabolism (PubMed:25002546).
What are the official names of this protein?
L-amino acid N-acetyltransferase AaaT, L-methionine N-acetyltransferase, L-phenylalanine N-acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: FBP2_DROSI
Sequence: MFDWTGKNVVYVGSFSGIGWQMMMQLMQKDIKMMGIMHRMENVEMMKKLQAINPSVKVVFMQMNLMGKMSIDQAMKKMGQMMGHIDVMINGEGVLLDKDVETTMGMNLTGMIHSTMMAMPYMDKTQMGMGGMVVNMSSVYGLEPAHAFAVYAAAMHGILGFTRSMGDKMIYQKTGVMFMAMCPGLTNSEMMMNLRDNVTWHHSESMVEAIESAKRQMPEEAAMQMIHAMEMMKNGSMWIVNMGQLKEVMPTMHWQM
What are the official names of this protein?
Fat body protein 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: HSCB_RALSO
Sequence: MNSASDTHFSLFGLPEHFEVDDGALNAAYRTVQSRAHPDRHAHASDAERRVAMQWATRANEAYQTLRDPLKRATYLLHLRGVDVQAENNTAMPPAFLMQQLEWRESLADAKAAGDLDALDDLLAMLRGEKRARYQTLAGLLNGGGHDAAAADAVRQLMFIEKIERDTAEAIDRLDD
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: MMPL3_MYCS2
Sequence: MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQSVAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKDHEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKNYQVVEPELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVVFSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAILGPRVDALGVTTLLKIPFLANWQFSRRIIDWFAEKTQKTKTREEVERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPDNAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVSGFTDPDNDPEKMWKERPANDSGSKDPSVRVIQNGLENRNDAAKKIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVLMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVMKLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRESETDQRALVGVGAPPPPPRPHDPTHPAPEPVRPMPPMRSNAPSAAGTARISTPPQPPQPPQAPAQQAGDEPATTRFAMARNAVRNAVNSAVHGGAGSAAAPTERAPRPGGPAQPPAPPQREEREIESWLGALRGPAPAKNVPQPPAQPQRPSTDTTRAMPPQGRPPAGPADRGNENAPTTAFSAQRPPNGGAPADATTAIPTPPQREQEPSTEKLNTREDAPEDPETKRRGGGMSAQDLLRREGRL
What is the function of this protein?
Transports trehalose monomycolate (TMM) to the cell wall (PubMed:31239378, PubMed:22520756, PubMed:28698380).  Flips TMM across the inner membrane.  Membrane potential is not required for this function (PubMed:28698380).  Transports probably phosphatidylethanolamine (PE) as well.  Binds specifically both TMM and PE, but not trehalose dimycolate (TDM).  Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) (PubMed:31113875).  Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness (PubMed:28703701).
What are the official names of this protein?
Trehalose monomycolate exporter MmpL3, TMM exporter MmpL3, MmpL3 transporter, Mycobacterial membrane protein large 3.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Cell septum. Cell tip. Note=Colocalizes with TtfA to the cell poles and septa. Trehalose monomycolate (TMM) synthesis is not required for localization to the poles or septa.
Protein: TSAD_ACISJ
Sequence: MSQLILGIESSCDETGVALVRAGEGGAVPVLLAHALHSQIDMHQAYGGVVPELASRDHIRRVLPLTREVLRESGERLEDVDVVAYTRGPGLAGALLVGAGVACALGAALDKPVLGVHHLEGHLLSPFLSSDPPEFPFVALLVSGGHTQLMRVEGVGRYEILGETIDDAAGEAFDKSAKLMGLGYPGGPALSRLAEQGSATAFKLPRPLLHSGDLDFSFAGLKTAVLTQAKKLGDELTARKADLAASTEAAIVEVLVKKTLAALQKTGLQRVVVAGGVGANRHLRAQLNAACARAKVRVHYPELHLCTDNGAMIAMAAAMRLQAGQQQPNRDYAFDVKPRWPLDAITLAA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATD_CITK8
Sequence: MFDIGVNLTSSQFVKDRDDVVTRALAAGVSGMLLTGTNLHESQQAQKLAQRYACCWSTAGVHPHDSSQWQSETEDAIVALARQPDVVAIGECGLDFNRNFSTPQEQERAFQAQLRIAAELQMPVFMHCRDAHARFLALLEPWLDKLPGAVLHCFTGTREEMQECIDRGLYIGITGWVCDERRGLELRELLPFIPAEKLLIETDAPYLLPRDLTPKPASRRNEPAHLAHILARVAHWRGEDPQWLAATTDANVKTLFGIAF
What is the function of this protein?
3'-5' exonuclease that prefers single-stranded DNA and RNA.  May play a role in the H(2)O(2)-induced DNA damage repair.
What are the official names of this protein?
3'-5' ssDNA/RNA exonuclease TatD, DNase TatD.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.