PharMolix/UniProtQA huggingface dataset:
Protein: GRLF_DICDI
Sequence: MKIKNFIYFLIYFIFLFKVINGQNKTCKISVLLSGDKSDLGYNYMMNEARVLAESQLHMYPFSIYYEHLEESTLEAEHAIQDSVDKGANLIVVSSVIHFSLGVKYATKYKDEPIYWIIRGSKLVPTLPKVVILNFNSFELHYLLGYYAGLATKTGVVGFVSPGIGINTLSCDNSFYIGAKYARSNITFLDIHTGSWYNPEVSYKAAQKLIENGADVIGMSQDDMSVQKAIMDSGGLGLGVTGYPGHYQFGSDVAYSYLTNWTNLFITYANHVINDDWPAFDSFFTNLSRKDAIFMDDFSFRVPIDIQTKTKIELENLMNTSYAPYKSDPILESIGLQFSGNWINDTQFRANTKILPSYGDSTVDYPESLKIGVTVVSGFCIFLCLISMIIVIKFKEAKVIKSSSPIFCLLILFGCIVIFVGCIMFARSPTDGSCRSRVWLLSLGYTIFLGNLMVKNWRIWLLFDNPKLKKRAITNWKLYPWVSGIVIIDIVILSIWQALGDIVAESRTGIDSLTKYEYRNVCASSDQGSIALYLLLVFHGLILLVACFISFKIKVVDIEEFNESKPITTSVYIITFCLFIVIPIMVSSPTVTTQTTIICICALITTMLSIILLFGTKFFKMITVGLELGQTFVTSTKSSSHSQRTKSSKSSNGSGPKINGFGGNVLNLDDDSDEISSEKEKKKPIESNPKDHMAVFTSDEETSKASKFSSEQFSREQINDNIILENNNDNEEKQKDEEEIKEEKLLVSEIQAKRLSLEQNGQTEIDSNDV
What are the official names of this protein?
Metabotropic glutamate receptor-like protein F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NIKE_STAAS
Sequence: MIELKHVTFGYNKKQMVLQDINITIPDGENVGILGESGCGKSTLASLVLGLFKPAKGEIYLSDNAVLPIFQHPLTSFNPDWTIETSLKEALYYYRGLTDNTAQDQLLLQHLSTFELNAQLLTKLPSEVSGGQLQRFNVMRSLLAQPRVLICDEITSNLDVIAEQNVINILKAQTITNLNHFIVISHDLSVLQRLVNRIIVLKDGMIVDDFAIEELFNVDRHPYTKELVQAFSY
What is the function of this protein?
Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Nickel import system ATP-binding protein NikE.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PRIS_STAMF
Sequence: MSRQESSNKFFIKKILREYYSRKPLEEPLYIHKREIAIHSLEDEAYIRHLSFPSITHLYNFILNEKTPLHLYYSSAYYESPSVNKMELKGWIGSDLMFDLDSDHYPGCDKILSICIEENTIYDGKIKTCPKTESKPVIHPLIKTECIQKAYRDALRIKYILEDELGLKNIKIYFSGNRGFHVKVIDEKIWDLESDERREIASYISLENFDINKLFPVIGKRKKYVIITRNEHGIRKRVLDYVIKNNIVNGNELFIKLPLKLLEETINDLTIPIDIVVTMDISRLSRFGNSINGKSGLITKLIEPLDNYEFDINDFCPWSGNIVVKPLIDISGLQVFDEKIDLKRGVKKILDSKIAVYLTLKGIVKIISDEKLVIKNV
What is the function of this protein?
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  The small subunit contains the primase catalytic core and has DNA synthesis activity on its own.  Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase small subunit PriS.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: YXEA_BACSU
Sequence: MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQIDRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVKFEDMPDSVQSKLK
What are the official names of this protein?
Uncharacterized protein YxeA.
Protein: RECX_STAHJ
Sequence: MTKITKIEVQKNNKERFNLFLDEVFEMGIDIDTLVRFNLKKGQILEPSDMENIQKYEHYRLGINMAIQYLSYKKRTEKEVRQHLQQNEISDIAIQQVIDYCYRESYINHEDYAESLKNTMINTTDKGPEIFRQKLYQVGIEPNIINTYVPIYEEEQSFEAVIEVAKKIMKTKKGPEIKIRQKVLQSLIQKGYSMDVVQQAIAELNFEQDENILDDLLQKDLEKVYTKQRRKYDGQQLVMKTIESLMRKGYKYDKIKSKLEESGILDE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAR1_CRYNB
Sequence: MFIINWFWDVLASLGLMNKSAKLLFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVKFTTYDLGGHIQARRLWRDYFPEVDGIVFLVDSADAERFAESKAELDSLLSIESLAQVPFLILGNKIDAYGAVSEEQLRHELGLYQTTGKGKIPLRDIRPIEVFMCSVVMRQGYGEGFRWLSQYI
What is the function of this protein?
Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.  SAR1 controls the coat assembly in a stepwise manner.  Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex.  These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles.  Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity).
What are the official names of this protein?
Small COPII coat GTPase SAR1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. SAR1 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ARNF_SALPA
Sequence: MGVMWGLISVAIASLAQLSLGFAMMRLPSIAHPLAFISGLGAFNAATLALFAGLAGYLVSVFCWQKTLHMLALSKAYALLSLSYVLVWVASMLLPGLQGAFSLKAMLGVLCIMAGVMLIFLPARS
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS2_STAA3
Sequence: MAVISMKQLLEAGVHFGHQTRRWNPKMKKYIFTERNGIYIIDLQKTVKKVDEAYNFLKQVSEDGGQVLFVGTKKQAQESVKSEAERAGQFYINQRWLGGLLTNYKTISKRIKRISEIEKMEEDGLFEVLPKKEVVELKKEYDRLIKFLGGIRDMKSMPQALFVVDPRKERNAIAEARKLNIPIVGIVDTNCDPDEIDYVIPANDDAIRAVKLLTAKMADAILEGQQGVSNEEVAAEQNIDLDEKEKSEETEATEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: NCAP_I76AA
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMINGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYKRVDGKWMRELVLYDKEEMRRIWRQANNGDDATAGLTHLMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGPAVASGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACNSAAFEDLRVLSFIRGTKVSPRGKLSTRGVQIASNENMDTMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPAFSVQRNLPFDKPTIMAAFTGNTEGRTSDMRTEIIRMMEGAKPEEMSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: BAG5_BOVIN
Sequence: MEMGNQHPSISRLQEIQKEVKSIEQQVLGFSGLSDDKNYKKLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNANHPHRLEIQNIFQEAQALVKEKVVPFYNGGNCVTDEFEEGIQDVILRLTHVKTGGKVSLRKARYHTLTKICAVQEIIENCMKKQPSLPLSEDAHPSVAKINSVMCEVNKTRGTLIALLMGVNNKETCRHLSCVLSGLMADLDALDVCGHTEIRNYRKEVVEDINQLLRYLDLEEEADTTHAFDLGQNHSILKIEKVLKRMREIKTELLQAQNPPELYLSAKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYIDLKEALEKRKLLACEEHPSHKAVWDVLGNLSEIQGEVLSFDGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDLKSDEWEY
What is the function of this protein?
Co-chaperone for HSP/HSP70 proteins.  It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating Hsp70-mediated protein refolding (By similarity).  Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity).  Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity).
What are the official names of this protein?
BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5.
Protein: HTPX_THISH
Sequence: MKRIFLFLATNLAIIVVLSIVLRLLGVERILDESGTNLNLNALLIFAAVFGFGGSFISLAISKWMAKKTMRVHVIEQPRNSTEQWLLETVRRQAREAGIGMPEVGIFNSPDPNAFATGMSKNNALVAVSTGLMDRMNADEVEAVLGHEVAHVANGDMVTLALIQGVVNTFVIFLARVVGHFVDRVVFKNEQGHGPAFWITTIVAEIVFAILASIIVMWFSRQREFRADAGGARLAGREKMISALEKLRAVHTPSQMPDQMAAFGIRGGMGQGLKKLFMSHPPLEERIMALKAMQR
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS8_FRAP2
Sequence: MSMQDPIADMFTRIRNGLSAEKEVVSVPFSKMKMEIANFLVNEGYIKGCSKGTTLAGHPSIEIELKYHAGAPVIEMIKRVSRPSLRIYKSHEELPKVYGGFGVAIISTSKGLVSDRKARDLGVGGEIIGYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ZNF43_HUMAN
Sequence: MGPLTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPWEPMRRHEMVAKPPVMCSHFTQDFWPEQHIKDPFQKATLRRYKNCEHKNVHLKKDHKSVDECKVHRGGYNGFNQCLPATQSKIFLFDKCVKAFHKFSNSNRHKISHTEKKLFKCKECGKSFCMLPHLAQHKIIHTRVNFCKCEKCGKAFNCPSIITKHKRINTGEKPYTCEECGKVFNWSSRLTTHKKNYTRYKLYKCEECGKAFNKSSILTTHKIIRTGEKFYKCKECAKAFNQSSNLTEHKKIHPGEKPYKCEECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEKPYKCEECGKAFNWPSTLTKHNRIHTGEKPYKCEVCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWSSKLTEHKITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECGKAFTQSSNLTTHKKIHTGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFKWSSTLTKHKIIHTGEKPYKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKAFNYSSHLNTHKRIHTKEQPYKCKECGKAFNQYSNLTTHNKIHTGEKLYKPEDVTVILTTPQTFSNIK
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 43, Zinc finger protein 39, Zinc finger protein HTF6, Zinc finger protein KOX27.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS20_SALG2
Sequence: MANIKSAKKRAVQSEKARKHNASRRSMMRTFIKKVYAAIEAGDKAAALKAFNEMQPIVDRQAVKGLIHKNKAARHKANLTAQINKLA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: CATA3_MAIZE
Sequence: MTMDPTKFRPSSSHDTTVTTTNAGAPVWNDNEALTVGPRGPILLEDYHLIEKVAHFARERIPERVVHARGASAKGFFECTHDVTSLTCADFLRAPGVRTPVIVRFSTVIHERGSPETIRDPRGFAVKFYTREGNWDLLGNNFPVFFIRDGIKFPDVIHAFKPNPRSHVQEYWRVFDFLSHLPESLHTFFFLFDDVGVPSDYRHMEGFGVNTYTFVSAAGKAQYVKFHWKPTCGVRCILTDEEAALVGGRNHSHATQDLYDSIAAGSFPEWTLYVQVMDPDTEEQYDFDPLDDTKTWPEDLLPLRPVGRLVLDRNVDNFFNENEQLAFGPGLVVPGIYYSDDKMLQCRVFAYADTQRYRLGPNYLMLPVNAPRCAHHNNHYDGAMNFMHRDEEVDYYPSRHAPLRQAAPPTPLPPRPVAGRREKATIRKPNDFKQPGERYRSWDADRQDRFVRRFADSLGHPKVSQELRSIWIDLLAKCDASLGMKIATRLNMKANM
What is the function of this protein?
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.  Its levels are highest in the light period and are lowest in the dark period, hence it may be important for scavenging hydrogen peroxide at night, rather than during the day.
What are the official names of this protein?
Catalase isozyme 3.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS17_BARHE
Sequence: MPKRVLQGVVVSDKNDKTVVVKVERRYSHPLLKKTVRQSKKYKAHDESNQFKIGDQIFIQESKPISKDKRWIVVKDSVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: ALKS_PSEPU
Sequence: MKIKIINNDFPVAKIGLDRITTLVSAKVHNCIYRPRLSIADGTAPRVCLYRAPPGYGKTVALAFEWLRHRTTGRPAVWISLRASSYSEFDICAEIIEQLEAFELVTFSHVREGVSKPTLLRDLASSLWQSTSSNEIETLICLDNINQGLGLPLLHALMEFMLETPKSIRFAVAGNTIKGFSRLKLAGAMQEHTEKDLAFSADEAVALVEAEAVLGVSEVQIEALVQEMEGWPVLIGFLLKCELPAKSISTVVEIDNYFNDEIFEALPERYRVFLVNSSLLDVVTPDGYNYVFKCVNAASCIKYLSTNYMLLRHVEGEPAQFTLHPVLRDFLQGIAWAENPAKRSYLLKRAAFWHWRRGEYQYAIRIALRANDCRWAVGMSEGIILDLSFRQGEIDTLRHWLSELPVKDLHKNPIVLICFAWVLYFSQQSARAEKLLKDLITPPDKKNKWQEKGWPQLVFAIGKATNDEMLLSEELCNKWISLFGDSNAVGKGAALTCLAFIFASEYRFAELEKVLAQAQAVNKFAKQDFAFGWLYVAKLQQALASGKMSWARQLITQARTDSGAQIMETAFTSKMLDALELESNYELCRLDTSEEKFSEILEFIANHGVTDVFFSVCRVVSAWRLGRNDLNGSIEILEWAKAYAAEKNLPRLEVMSQIEIYQRLLFQGVTYINTLQAFEDRKIFSGPHSAPLKARLLLVQSLALSRDQNFHLAAHRALLAIQQARKISAGQLEVRGLLYLAGAQAGGGTLKKAQHNIAYALEMAKQLQCFQTVLDEIRLIKRLIPTSCEVFAAVNLDQAIGAFSLPQMVEIRKSAENKAGDFLTLKQVSVLKLVKEGCSNKQIATKMYVTEDAIKWHMRKIFTILNVKSRTQAIIEAERQGVI
What is the function of this protein?
May act as a transcriptional regulator of AlkB.
What are the official names of this protein?
HTH-type transcriptional regulator AlkS.
Protein: EZH2_MOUSE
Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
What is the function of this protein?
Polycomb group (PcG) protein.  Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene.  Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.  Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2.  Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.  The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems.  Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.  EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA.  Regulates the circadian clock via histone methylation at the promoter of the circadian genes.  Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.
What are the official names of this protein?
Histone-lysine N-methyltransferase EZH2, ENX-1, Enhancer of zeste homolog 2.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in trophoblast stem cells.
Protein: RRAA_SALAR
Sequence: MKYDTSELCDIYQEDVNVVEPLFSNFGGRSSFGGQIITVKCFEDNGLLYDLLEQNGRGRVLLVDGGGSVRRALVDAELASLATQNEWEGLVIYGAVRQVDDLEELDIGIQAIAAIPVGAAGEGIGESDVRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_AGRFC
Sequence: MSDGQKLTHIDASGEAHMVDVGDKAETVRVAVAEGFVKMKPETLALIRDGNAKKGDVIGTARLAGIMAAKQTANLIPLCHPLMLTKVAVDITEDTGLPGLRVEAMVKLSGKTGVEMEALTAVSIACLTIYDMAKAADKGMEIVNIRLLEKSGGKSGDFRRQES
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: ALLA_SALEP
Sequence: MKLEVLPLDQKTFSAYGDVIETQERDFFHINNGLVERYHDLAKVEVLEQDRTLISINRAQPAAMPIVVHELERHPLGTQAFVPMNGEAFVVIVALGDDKPELSTLRAFISNGRQGVNYHRNVWHHPLFAWQTVTDFLTVDRGGSDNCDVESIPTHELCFA
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: UREG_MYCA9
Sequence: MPPHLIDGQPHQHIDRPRRVRQPGEPLRIGIGGPVGSGKTALVAALCRTLRDEISVAVLTNDIYTTEDADFLRRHAVLPDERITAVQTGGCPHTAIRDDITANLDAIEDLIATNEPLDLILVESGGDNLTATFSSGLIDVQIFVIDVAGGDKVPRKGGPGVTFSDLLVINKTDLAPMVGADLTVMARDAAAVREGRPTAMISLTEDPAASEVLAWVRAHLTEAHQTDHAH
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTHS_BACC7
Sequence: MTTTTTVKSDIEIAQEASMKKIQEIAAELNILEDELEPYGHYKGKLSLDIFKRLQNEEDGKVVLVTAINPTPAGEGKSTVTVGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFSQVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTLGIDTRKIVWKRCVDLNDRALRNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVTVKDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDYVITEAGFGADLGAEKFLDIKARAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALAKGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQEWCNERGYAVSLTEVWEKGGQGGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQYEGEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPGLPKQPAALQMDVNEDGKAVGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: SYR_MYCSK
Sequence: MTPADLADLLRTTATAVLTERDLDTAALPATVTVERPRNPEHGDYATNLALQVGKKVGVNPRELAGWLAEALTATAGIASAEVAGPGFVNLRIEAAAQNVIVGDIITSAERYGHSAALAERNINLEFVSANPTGPIHIGGTRWAAVGDALGRLLATQGAAVVREYYFNDHGAQIDRFVSSLIAAAKGEPTPEDGYAGSYIGDIAAQVLAKDPGALELPDDEMRETFRAIGVDLMFDHIKISLHDFGTDFDVFTHEDSMHTSGRVEEAIARLRENGAIYEKDGATWLRTTDFGDDKDRVVIKSDGAPAYIAGDLAYFLDKRQRGFDLCIYMLGADHHGYIARLKAAAAALGDDPDTVEVMIGQMVNLVRDGQPVRMSKRAGTVITLDDLVEAIGVDAARYSLIRSSVDTPIDIDLALWSSASNENPVYYVQYAHARLSALARNAADLGVVADTAHLDLLTHDKEGTLIRNLGEFPRVLESAAALREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEAPGSLHQARLALCQATRQVIANGLAILGVSAPERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPH_ECO5E
Sequence: MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRSETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFVCYAREQVMTILPDSPPRFINLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLDAHYAALETRFWQFYPRMMAQASRKAL
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: GPSB_LACP3
Sequence: MDSNKETKFSIQYGPKDILDKKFKNKVRGYDPDEVDEFLDGIIRDYEAFTNEIDRLKEENTKLFSRVDELTKQLSVSKNVSAQTPQTNAAATNYDILKRLSNLERHVFGSKLSDSSVDNHDDGNHSDVDQY
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: RS21_LEPCP
Sequence: MTTIRVKENEPFDVALRRFKRTIEKLGLLTELRAREFYEKPTAERKRKKAAAVKRHYKRVRSMQLPKKLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.