PharMolix/UniProtQA huggingface dataset:
Protein: RNPC3_RAT
Sequence: MAVPEPSMPLSRGGPGSASLSPPRGDRTLLVRHLPAELTAEEKEDLLKYFGAQSVRVLSDKGRLKHTAFATFPNEKAAIKALTRLHQLKLLGHTLVVEFAKEQDRVHSSCPASNAEKKKRLDDTVENDKEKKEPDVLTVENGIAPNHGLTFPLNSCLKYMYPPPSSTILANIVNALASVPKFYVQVLHLMNKMNLPTPFGPITARPPMYEDYVQLHAPLPPTSPQPPEEPPLPDEDEDLSSKESEYESSDEEDRQRMNKLMELANFQPKRPKTVKPRHVRKKRKIKDMLTVPSPASQSLHPVLLPSDVFDQPQPVGNKKIEFNISTNVPAALNKDLETEQNNEEKNSDSPDTGLDDSNTGFGKLFPKPNVNITEEIKEDSDEMPSQFISRRELEKGRISREEMETLSVFRSYEPGEPNCRIYVKNLARHVQEKDLKFIFGRYVDFSSETQRIMFDIRLMKEGRMKGQAFVGLPNEKAAAKALKEANGYVLFGKPMVVQFARSARPKHDSKEGKRK
What is the function of this protein?
Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns.  U12-type introns comprises less than 1% of all non-coding sequences.  Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA (By similarity).
What are the official names of this protein?
RNA-binding region-containing protein 3, RNA-binding motif protein 40, RNA-binding protein 40.
What are the subcellular locations of this protein?
Nucleus.
Protein: GT253_HUMAN
Sequence: MRAARAAPLLQLLLLLGPWLEAAGVAESPLPAVVLAILARNAEHSLPHYLGALERLDYPRARMALWCATDHNVDNTTEMLQEWLAAVGDDYAAVVWRPEGEPRFYPDEEGPKHWTKERHQFLMELKQEALTFARNWGADYILFADTDNILTNNQTLRLLMGQGLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRRGCFRVPMVHSTFLASLRAEGADQLAFYPPHPNYTWPFDDIIVFAYACQAAGVSVHVCNEHRYGYMNVPVKSHQGLEDERVNFIHLILEALVDGPRMQASAHVTRPSKRPSKIGFDEVFVISLARRPDRRERMLASLWEMEISGRVVDAVDGWMLNSSAIRNLGVDLLPGYQDPYSGRTLTKGEVGCFLSHYSIWEEVVARGLARVLVFEDDVRFESNFRGRLERLMEDVEAEKLSWDLIYLGRKQVNPEKETAVEGLPGLVVAGYSYWTLAYALRLAGARKLLASQPLRRMLPVDEFLPIMFDQHPNEQYKAHFWPRDLVAFSAQPLLAAPTHYAGDAEWLSDTETSSPWDDDSGRLISWSGSQKTLRSPRLDLTGSSGHSLQPQPRDEL
What is the function of this protein?
Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier.  Does not express any beta-galactosyltransferase activity in vitro.
What are the official names of this protein?
Inactive glycosyltransferase 25 family member 3, Cerebral endothelial cell adhesion molecule.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 25 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: CYC21_CLITE
Sequence: DLQCAETCVHSPCIGPCYCKHGLICYRN
What is the function of this protein?
Probably participates in a plant defense mechanism.  Not active against Gram-negative bacterium E. coli ATCC 700926 or Gram-positive bacterium S. aureus ATCC 12600 up to a concentration of 100 uM under low-salt conditions.
What are the official names of this protein?
Cliotide T21, Cyclotide cT21.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family.
Protein: TUSA_PECAS
Sequence: MTDPFTNPDKTLDAQGLRCPEPVMMVRKTVRQMETGQTLLIIADDPATTRDIPGFCVYMEHELLAQETEQVPYRYLLRKGQ
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking in the cell.  Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA.  Interacts with IscS and stimulates its cysteine desulfurase activity.  Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation.  Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
What are the official names of this protein?
Sulfur carrier protein TusA, Sulfur mediator TusA, Sulfur transfer protein TusA, tRNA 2-thiouridine synthesizing protein A.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_ECOL6
Sequence: MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: XNI_SHESH
Sequence: MNTFLIIDGMNLVRRMHAAQPNENDVNGLDIRVGSACKKLVKYHQPTHVAVVWDGDDISWRKHLFEDYKKGRKPMPEALSNTLPALKSYLAEQGVNSIDAASEADDVIATLASKLVANGGKAIIVSTDKGFTQLSDPYIQRWDHFNQHYMTIEEREEKLGVEHSQFIDYLALAGDSGNKIPGVPGIGPKSAIELLRTFRSLANIYASLDKIGAKQAKKLEAGKQMARLSYKLVQLQTDIPLNINLSQFRLPNPNA
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: THIM_LIMF3
Sequence: MQNAIATIKETNPIVLTVANNVTPADVANGLNALGASPMMSQTPEEADDMVNIAQAAAINLGTLNPHQRGEMEAVMEAAKKYHKPTVLDPVACGATMYRLRVVTELLHQYHFTVIRGNAGEIATLAGVEWQSHGIDAGEGNADLEKVARLAAEKLGSVIVLSGEVDIVTDSTRLARLPYGSPAFKTHVGTGDMLSSLIGAFLATNDDAFDAAVDAVTTFTLCGQAVEDQRPGNWYPGLLNNLDAVTDQQLAAWQ
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: APAH_BAUCH
Sequence: MSTYFIGDIHGCYDELQTILEKVAFDPLIDTLWLTGDLVARGPSSLEVLRMIRRLGNSVRIVLGNHDLHLLAVYTGIMRNRIKDHTIPLLTAPDAEDLMNWLRYQPVLQVDNKKKILMAHAGITPQWNIDTALQCASEIETVLRSESYPLFLHSIYEDIPNYWSNELSYRARLQFSTNVFTRMRYCFPNGKLDMLCKDIPNKAPEPLRPWFNLPSTIVEKYSIIFGHWSSLLGKGTPTGIYGLDTGCCWGGKLTLLCWEDKKIIQIPSQKKRNKKCSYLCYNGKGKKN
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: FIBB_VULVU
Sequence: EYYDDTDEEERIVSTVDAR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: PIGJ_SERS3
Sequence: MSNDKHIAPLAVVSMGCVLPGVDHFRALDTIADWETVFQSASPLAWSETSRPIQGRQMDDSGFDFKKFSIPPLFRKAVSRETRLALRAAEDALAGLVLPESLRDCCDQFCAIHLGSDAAYRNATKVGALRALAEKLQAQGCPAAEVRRRLDDYKQPLAESLGCSSHDRVGEMASSIPARIAHFAHTRGKCQTLDGADKGGLRLLQLAQDCFRYHDSQMAVLTSVQCFHHRPQAYMLLEQGVSQDACWLEGAISLVVCPLAVAHEQGWPVLTQLGDIVTTHDGSPQPEADHPAALYFAGANQVFCQIVEMVLRQHQRCEGRSFTGGRWQVNVAQTQSLTPAVDDRVAIVDYQPITGHPLDKTQFWQTLEQGEDALREHSAAHVNAEAFVRTTQQKLSTYIHRTMSFPAHSPSDVALKKPMMPAKKQRLDVTQLYALNSCHSWSEKIRQFERVAIIIASNLSLSADRLQAMRALWSGLPGSEGAIPLPELPSINHWSWYGACGIGTAQLLAQYFGISADCYAVEAACASSLAAVHDAVRALQAGRYDAVIVGGIETATLERDLVLCSAQMMLSVSRIRPFSQGADGFTPGDGGGFVMLTHHPVPRAIATIEAISGSCDSYSMTAPDPLGQALAIKKTLSLTAIDAQTVQYLEAHGTGTELGDRSEVMSLKYSYHRDKHSPLYIGSAKYNFGHCFAGAGALSLCKVLSAFEHERIPPTPVSELNVDLPLGDIPAEVPQQAIPWRLSEDGQRKAAINAFGTGGINYHLVIRQSS
What is the function of this protein?
Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig).  Catalyzes the decarboxylation on the malonyl group attached to PigH to yield a C2 carbanion of acetyl-S-PigH.  Then, the heterocyclic pyrrole group of PigG moves to the PigJ active site Cys-525 to generate a transient pyrrolyl-S-cysteinyl PigJ intermediate (acyl donor) whose pyrrolyl group is captured by the C2 carbanion of acetyl-S-PigH to yield the pyrrolyl-beta-ketoacyl-S-PigH.
What are the official names of this protein?
Beta-ketoacyl synthase PigJ, PKS.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Protein: DAPA_CHLAB
Sequence: MKLLTASVTPFLPDHSIDFLSFENLLRFQERESHGVVLLGSTGESLSMTAKEKESLVSYACSLNLKVPIIVGVPGTSLHEASEWIHTCQSYPIYGFLITTPIYTKPGVHGQTLWFESLLNKANKPAILYNIPSRSGTTLYLDTVRSLAAHPFFYGLKDSGGSIKHCQEYAQMSSDFVLYCGDDGLWPQMYECGARGLISVLSNIWPKEAREWVEDPHHQYRADLWREVSSWLNQTTNPIAIKALLAYKQVIAHNTLRLPLSIQDLQCAESIPEIIKKMAQWKYSCAHV
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS4_ACTP7
Sequence: MQKKSIIIPALDLIDGNVVRLHQGDYAKQTTYSDNPIEQFASYLAQGAEQLHLVDLTGAKDPAKRQTALIGKIIAETNCQIQVGGGIRTEQDVADLLAVGANRVVIGSTAVKDRAMVKGWFEKYGAEKFVLALDVNIDASGQKIIAISGWQEASGVSLEELIEDYQVVGLQHVLCTDISRDGTLAGSNVNLYREICAKYPKIHFQSSGGIGSLDDIKALKGTGVSGVIVGRALLEGKFNVAEAIECWQNG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1503_SHEFN
Sequence: MAKVAFIGLGVMGFPMAGHLVKQGHDVTVYNRTGAKATQWVEQYGGKKADTPKDAAQGQDIVFTCVGNDDDLRQVVLGEHGIVHGMHAGAILVDHTTASADVAREIAAYIEPLNIAFLDAPVSGGQAGAENGALTVMMGGDQAHFDTVKPVISAYSRCAELLGPVGAGQLTKMVNQICIAGVVQGLAEGLHFAKSAGLDGLKVIEVISKGAAQSWQMENRYKTMWQGQYDFGFAIDWMRKDLGIALDEARRNGSHLPVAALVDQFYSEVQAMKGNRWDTSSLLARLEKSRS
What are the official names of this protein?
Uncharacterized oxidoreductase Sfri_1503.
What is the protein family that this protein belongs to?
Belongs to the HIBADH-related family.
Protein: UGPQ_ECOLI
Sequence: MSNWPYPRIVAHRGGGKLAPENTLASIDVGAKYGHKMIEFDAKLSKDGEIFLLHDDNLERTSNGWGVAGELNWQDLLRVDAGSWYSKMFKGEPLPLLSQVAERCREHGMMANIEIKPTTGTGPLTGKMVALAARELWAGMTPPLLSSFEIDALEAAQQAAPELPRGLLLDEWRDDWRELTARLGCVSIHLNHKLLNKARVMQLKDAGLRILVYTVNKPQRAAELLRWGVDCICTDAIDVIGPNFTAQ
What is the function of this protein?
Glycerophosphodiester phosphodiesterase hydrolyzes glycerophosphodiesters into glycerol-3-phosphate (G3P) and the corresponding alcohol.
What are the official names of this protein?
Glycerophosphodiester phosphodiesterase, cytoplasmic, Glycerophosphoryl diester phosphodiesterase, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the glycerophosphoryl diester phosphodiesterase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLK8_RAT
Sequence: MGRPPPCAIQTWILLFLLMGAWAGLTRAQGSKILEGQECKPHSQPWQTALFQGERLVCGGVLVGDRWVLTAAHCKKDKYSVRLGDHSLQKRDEPEQEIQVARSIQHPCFNSSNPEDHSHDIMLIRLQNSANLGDKVKPIELANLCPKVGQKCIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPGKITEGMVCAGSSNGADTCQGDSGGPLVCNGVLQGITTWGSDPCGKPEKPGVYTKICRYTNWIKKTMGKRD
What is the function of this protein?
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV.  Also cleaves L1CAM in response to increased neural activity.  Induces neurite outgrowth and fasciculation of cultured hippocampal neurons.  Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity.  Involved in skin desquamation and keratinocyte proliferation.  Plays a role in the secondary phase of pathogenesis following spinal cord injury (By similarity).
What are the official names of this protein?
Kallikrein-8, Brain serine protease 1, Neuropsin, NP, Serine protease 19.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Kallikrein subfamily.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes.
Protein: TUSB_SALTI
Sequence: MLHTLPHCASGVDFPALLRLLKEGDALLLLQDGVTVAIEGNRFLESLRDAPITVYALKEDIDARGLGGQISDSVVRVDYTEFVRLTVKYANQMAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METXA_TRIV2
Sequence: MNYQDFISEQTEYYHLPVPFELEGGGVLTGVQVAYRTWGKLNSAGDNGVLICHALTGSADADEWWEGLLGANKALDSDRDFIICSNILGSCYGTTGATSINPQTGIPYGASFPAITIRDMVRLQAALIQHLGIKSLQLVIGGSLGGMQVLEWALLYPEIVQAIAPIATSGRHSAWCIGLSEAQRQAIYADPNWKGGNYTKEQPPSQGLAVARMMAMSAYRSWQSFTARFGRQYDAVADQFAIASYLQHHGQKLVQRFDANTYITLTQAMDSHDVAQGRDYKSVLQSIKQPALVVAIDSDILYPPTEQQELADFIPDAQLGWLQSSYGHDAFLIDIATLSQLVINFRQSLSLKTFSDVTT
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPH1_NEOFI
Sequence: MSVSGDDSDDYFDHEIDDVIVPGTPDAVKSAQTDNRPAKRRRLDAGVFDESDISIDQGDGEDEFQSPDRRSVNAVQSEDVERTSKYKVFVPKRKNFQENIFVTQLTQPPSPPEMIRGPRWKKPGPEPLAPKPTTTTVDASHQPDQYYDEDKEIEAAIAASLRSFEEENGGNIPSTASRSTPALTAVAPSAALKEAAADVPFNLDDIPDDAFDSDLSLSPPRTTSQATRGPPVQSQFRTNRPLGLRQSTLFDMAARNSDIPSQRGEQILSPPEKNEPPTHHKLNEEAINTWVYPTNLGKTRDYQFNIAQRGLFHNLLVALPTGLGKTFIAATIMLNWYRWTKSAQIIFVAPTKPLVAQQISACFQVAGIPRSQTTMLTGEAAPGIRAEEWKSKRVFFMTPQTLVNDLKSGIADPKRIVLLVVDEAHRATGGYAYVEVVKFLKRYNKSFRVLALTATPGSTVESVQAVIDGLGIAKVEIRTEQSLDIREYVHARDTEVQTFKNSDEMVLCMELFTRTLQPLVDQLRNLNAYWGRDPMALTAFGLTKARQQWMGSDAGRNANLGLKGKVNAIFTVLASLAHAIDLLKYHGITPFYRHLLHFQSNTDGQKGGKYQRQIVQDESFKKLMNHLQPWTKNPEFIGHPKLEYLKQVVLNHFMDRGEGTAANGDQSQSATRIMIFVHFRDSAEEVVRVLKRYEPLIRPHVFVGQSSAKGSEGMDQKTQLSIVQKFKKGTYNTIVATSIGEEGLDIGEVDLIVCYDSSASPIRMLQRMGRTGRKRAGNIVLLLMQGKEEESYIKAKDNYEKMQQMIASGTRFTFHDDTSPRILPPGVRPVAEKRQIDIPVENTQADLPEPRKRARPPKRPPKKFHMPDDVETGFAKASSLTGKVTKKAETKKAVRKPTPEPVEVPALEEVLLTPGEQQDLERRYCHIGGTSPEFIRNPRVDAYPRLQSVPRPTKAIKHGSLTSRMIGTLQKMSKVSVDCERRYRKVLALESSKEIVDSVLSREPGSPAQNSGRLGKKPHAFKRPSATSRPNNVHVREDENEDNCTPELLSPEKLMSSFLEPHTERPPYSSQRSQDAFELDFPDVETLLNRSAERHVSRKRNRFVLDDDTEE
What is the function of this protein?
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance.  Capable of unwinding D-loops.  Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair.  Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
What are the official names of this protein?
ATP-dependent DNA helicase mph1, FANCM-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RR3_STAPU
Sequence: MGQKIHPLGFRLGVTQSHLSNWCVQPSQYSELLQEDEKLRGCIKEYVRKYVRTAENYGGIDRIEIQRKTSAIKVEIHTGFPKLFVEKLGPRLKEIRREMQNTLQKSKHLKFIISLAEVEKPYAKATILAEYIAVQVERRVAFRKTIKKAIQLAKEQGNVKGIKIQIAGRLNGAEIARSEWAREGRVPLQTLRAQIDYCHYPAHTIYGVLGIRVWIFQEK
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MLTF_HAEI8
Sequence: MKGLFLRIITALALLFWAIDMVFPWQFLRHTEENHYTAIQARGSLYVGTINNQISYFINKDSERGFEYELAKAFADTLGVELEMKIFDNQEQLFDELDKHNIDLAAAHLLYHPKNAERFQIGPAYHSASWQLAYRKNENRPKNLGNVKKDIYISNNLALEETLKELQKQYPQLTWKRNQALTQEELLLQLAEGKIPYVIANSIDIAAIQQIKPELAIAFDITDEANVHWYLPNSPYRDLQTALLNFMNNAEETGLLDNLKEKYLGHISQFDYVDTRSYMNAIENTLPQFSPLFEKYKGELDWRLLAAVAYQESHWNPDATSPTGVRGIMMLTKNTAQHMKISDRTDPEQSIKAGSEYLHWLISQLPESIEKEERIWFALVAYNIGLGHLIDARRLTQNLGGNPDNWLNVKKNLPLLAEKRYYSQLKYGYARGYEAYQYVENIRRYMNSIVNYHRVQENQTTNDNANNESAVKNLEEIKENKD
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: RAB4A_ECHMU
Sequence: MESDRFDYLFKFLIIGNAGTGKTCILRRYTERKFFPNTQHTIGAEFGSRVISVDGTHVKIQIWDTAGQERFRSMARSYYHDAVGTLLVYDITNRTSFGAVEQWLGDARHLATPGVVVILVGNKKDLRDTDGQVTHWEANTFAQENGLQFIETSALTGENIDDAFTSCVRVLLSKVKSGELGADRLLVGSNKQHLQAVNLTASATSVSASQSSAATAHSDTCLC
What is the function of this protein?
Protein transport.  Probably involved in vesicular traffic (By similarity).
What are the official names of this protein?
Probable Ras-related protein Rab-4A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: SYK_PSEA8
Sequence: MSDQQLDQHELQQEENKLIAQRKEKLAAVREARAIAFPNDFRRDAYFADLQKQYADKTKEELEAAAIPVKVAGRIMLNRGSFIVLQDSSERLQVYVNRKTLPEETLAEIKTWDLGDIIGAEGVLARSGKGDLYVDMTSVRLLTKSLRPLPDKHHGLTDTEQRYRQRYVDLMVNEETRHTFRVRSQVIAHIRRFLSERGFLEVETPMLQTIPGGAAAKPFETHHNALDMAMFLRIAPELYLKRLVVGGFEKVFEINRNFRNEGVSTRHNPEFTMLEFYQAYADYEDNMDLTEELFRELAQAVLGTTDVPYGDKVFHFGEPFVRLSVFDSILKYNPEITAADLNDVEKARAIAKKAGAKVLGHEGLGKLQVMIFEELVEHKLEQPHFITRYPFEVSPLARRNDEDPSVTDRFELFIGGREIANAYSELNDAEDQAERFMLQVKEKDAGDDEAMHYDADFINALEYGMPPTAGEGIGIDRLVMLLTNSPSIRDVILFPHMRPQA
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBD_ECOL5
Sequence: MAQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNEASQPVSVPQQEQPTAQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQHPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFIMGAIAGLICSPCTTAPLSAILLYIAQSGNMWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQVKTAFGFVILALPVFLLERVIGDIWGLRLWSALGVAFFGWAFITSLQAKRGWMRVVQIILLAAALVSVRPLQDWAFGETHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCVACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHLRDRQP
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PB1F2_I36A0
Sequence: MGQEQDTPWILSTGHISTQKGEDGQQTPKLEHCNSTRLMGHCQKTMNQVVMPKQIVYWKQWLSLRNPILVFLKTRVLKRWRLFSKHEWTS
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: END4_STAA2
Sequence: MLLGSHVSMSGKKMLEGSAIEAYEYGETTFMIYTGAPQNTRRKSIEDLNITKGHEVMEKYGLSNIVVHAPYIINIANTTKPETFNLGVDFLQQEIERTQAIGAKDIVLHPGAHVGAGVDAGINKIIEGLNEVLTNDNNVRIALETMAGKGTEIGRSFEELARIIDGVHNNERLSVCFDTCHTHDAGYNVKEDFDGVLNEFDKIIGVDRIKVVHVNDSKNDRGAQKDRHENIGFGYIGFDALNYIVHHDSFKDIPKILETPYVGEDKKNKKPPYKLEIEMLKQQQFDPELKNKVMQQ
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: DAPE_ANAMM
Sequence: MRLDDPVSLACRLMSYPSVTPDRSGAIPFLAELLSDLGFRCEILSFGNGDVEVKNLYAQYGNGHPNLCFAGHTDVVPPGGTWRTDPFSPQVKDGMLYGRGASDMKAAICAYISAVARLDSVPGCLSFLITGDEEGRWREYGTKSVLDWMTKNGICPDYCVLGEPSSRKRLGDCISIGRRGSLNFELSCRGVQGHVAYPELAHNPIDDVLCILRKIKDTTLDSGTDHFPPSHCEITSIDVGNDVENLIPSSATAAFNIRFNDLHTAESLYRDMDAICASVTSNYTLSHRCFGGASISQPSCYTATLCEVVKEVTGLDARLITDGGTSDACIISSFCPVAELGLPSGTAHKVDECVSVADVLTLAEIYHRFINRFFAVAQSRS
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.