PharMolix/UniProtQA huggingface dataset:
Protein: PYC2_YEAST
Sequence: MSSSKKLAGLRDNFSLLGEKNKILVANRGEIPIRIFRSAHELSMRTIAIYSHEDRLSMHRLKADEAYVIGEEGQYTPVGAYLAMDEIIEIAKKHKVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARHLAARANVPTVPGTPGPIETVQEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGNGTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDAVKLAKVCGYRNAGTAEFLVDNQNRHYFIEINPRIQVEHTITEEITGIDIVSAQIQIAAGATLTQLGLLQDKITTRGFSIQCRITTEDPSKNFQPDTGRLEVYRSAGGNGVRLDGGNAYAGATISPHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFIDDTPQLFQMVSSQNRAQKLLHYLADLAVNGSSIKGQIGLPKLKSNPSVPHLHDAQGNVINVTKSAPPSGWRQVLLEKGPSEFAKQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGAFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALNDLEQLKVGVNAVKKAGGVVEATVCYSGDMLQPGKKYNLDYYLEVVEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRTRYPDLPIHVHSHDSAGTAVASMTACALAGADVVDVAINSMSGLTSQPSINALLASLEGNIDTGINVEHVRELDAYWAEMRLLYSCFEADLKGPDPEVYQHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMVSNKLTSDDIRRLANSLDFPDSVMDFFEGLIGQPYGGFPEPLRSDVLRNKRRKLTCRPGLELEPFDLEKIREDLQNRFGDIDECDVASYNMYPRVYEDFQKIRETYGDLSVLPTKNFLAPAEPDEEIEVTIEQGKTLIIKLQAVGDLNKKTGQREVYFELNGELRKIRVADKSQNIQSVAKPKADVHDTHQIGAPMAGVIIEVKVHKGSLVKKGESIAVLSAMKMEMVVSSPADGQVKDVFIKDGESVDASDLLVVLEEETLPPSQKK
What is the function of this protein?
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
What are the official names of this protein?
Pyruvate carboxylase 2, Pyruvic carboxylase 2, PCB 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3147_BRASO
Sequence: MTTETAPITLYVDADACPVKDEIYRVAIRHGLAVIVVAGGFIRVPDDPLITRVAAGSGMDAADDWIAEHTGPDDIVITADIPLASRCVKAGSAVIAPNGKPFTEESMGMTLAVRNLMTDLRSSGEVTGGPRSFTPRDRSTFLSTLDTTIRRVQRQRAARIQQQS
What are the official names of this protein?
UPF0178 protein BRADO3147.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: CPL1_ARATH
Sequence: MYSNNRVEVFHGDGRLGELEIYPSRELNQQQDDVMKQRKKKQREVMELAKMGIRISHFSQSGERCPPLAILTTISSCGLCFKLEASPSPAQESLSLFYSSCLRDNKTAVMLLGGEELHLVAMYSENIKNDRPCFWAFSVAPGIYDSCLVMLNLRCLGIVFDLDETLVVANTMRSFEDKIDGFQRRINNEMDPQRLAVIVAEMKRYQDDKNLLKQYIESDQVVENGEVIKVQSEIVPALSDNHQPLVRPLIRLQEKNIILTRINPMIRDTSVLVRMRPSWEELRSYLTAKGRKRFEVYVCTMAERDYALEMWRLLDPEGNLINTNDLLARIVCVKSGFKKSLFNVFLDGTCHPKMALVIDDRLKVWDEKDQPRVHVVPAFAPYYSPQAEAAATPVLCVARNVACGVRGGFFRDFDDSLLPRIAEISYENDAEDIPSPPDVSHYLVSEDDTSGLNGNKDPLSFDGMADTEVERRLKEAISASSAVLPAANIDPRIAAPVQFPMASASSVSVPVPVQVVQQAIQPSAMAFPSIPFQQPQQPTSIAKHLVPSEPSLQSSPAREEGEVPESELDPDTRRRLLILQHGQDTRDPAPSEPSFPQRPPVQAPPSHVQSRNGWFPVEEEMDPAQIRRAVSKEYPLDSEMIHMEKHRPRHPSFFSKIDNSTQSDRMLHENRRPPKESLRRDEQLRSNNNLPDSHPFYGEDASWNQSSSRNSDLDFLPERSVSATETSADVLHGIAIKCGAKVEYKPSLVSSTDLRFSVEAWLSNQKIGEGIGKSRREALHKAAEASIQNLADGYMRANGDPGPSHRDATPFTNENISMGNANALNNQPFARDETALPVSSRPTDPRLEGSMRHTGSITALRELCASEGLEMAFQSQRQLPSDMVHRDELHAQVEIDGRVVGEGVGSTWDEARMQAAERALSSVRSMLGQPLHKRQGSPRSFGGMSNKRLKPDFQRSLQRMPSSGRYS
What is the function of this protein?
Processively dephosphorylates 'Ser-5' but not 'Ser-2' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).  This promotes the activity of RNA polymerase II.  Together with CPL2, required for male gametes fertility.  Multifunctional regulator that modulates plant growth, stress, and phytohormones responses.  Negative regulator of stress gene transcription involved in abscisic acid (ABA) mediated and jasmonic acid (JA) mediated signaling pathways, NaCl, osmotic stress, wounding, and cold resistance.  Regulates negatively the expression of jasmonic acid (JA) biosynthetic genes in response to wounding (PubMed:11874572, PubMed:12149434, PubMed:12149453, PubMed:15388846, PubMed:18506580, PubMed:18764923).  Forms a complex with RCF3 that modulates co-transcriptional processes such as mRNA capping and polyadenylation, and functions to repress stress-inducible gene expression (PubMed:23874224).  Dephosphorylates RCF3 (PubMed:26227967).  Involved in the dephosphorylation of EIF4A3.  This dephosphorylation retains EIF4A3 in the nucleus and limits its accumulation in the cytoplasm.  Is essential for the degradation of the nonsense-mediated mRNA decay (NMD) transcripts (PubMed:26887918).
What are the official names of this protein?
RNA polymerase II C-terminal domain phosphatase-like 1, FCP-like 1, Carboxyl-terminal phosphatase-like 1, AtCPL1, CTD phosphatase-like 1, Protein FIERY 2, Protein JASMONATE OVEREXPRESSING 1, Protein SHINY 4.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: DUT_POLNS
Sequence: MQSLQVKILDERMRDQLPTYGTPGSAGLDLRACIDEAITIAPGQTVLVPTGLAIYVEDPRYAAFILPRSGLGHKHSIVLGNLVGLIDSDYQGQLMVSTWNRGSTTFKLEPMERLAQLVVMPVQQVELKVVEEFTESSRGAGGFGSTGRA
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: NUOCD_ECOUT
Sequence: MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVGDFLKKLPKPYVMLFDLHGMDERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMMPQTWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQNTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRILEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMVEATKGINSYYLTSDGSTMSYRTRIRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YIDD_PORG3
Sequence: MRLIKAFLVQLLLLPIFFYKRFISPLTPPSCRFTPSCSSYAIEALRKYGPGKGLLLSIKRILRCHPWGGSGYDPVP
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RAS1_CANAW
Sequence: MLREYKLVVVGGGGVGKSALTIQLIQSHFVDEYDPTIEDSYRKQCTIDDQQVLLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSINSLNSFQELNSFYDQILRVKDSDNVPVLVVGNKCDLEMERQVSYEDGLALANSFNCPFLETSAKQRINVEEAFYGLVRNINQYNAKIAEAEKQQQQQQQQQNANQQGQDQYGQQKDNQQSQFNNQINNNNNTSAVNGGVSSDGIIDQNGNGGVSSGQANLPNQSQSQRQQQQQQQEPQQQSENQFSGQKQSSSKSKNGCCVIV
What is the function of this protein?
Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway.  The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form.
What are the official names of this protein?
Ras-like protein 1, Ras homolog type B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: PYRH_PROMP
Sequence: MTYKRVLLKLSGEALMGDKPYGIDPAIVQSIAEDVERVIANKVQLAIVVGGGNIFRGLKGSADGMDRATADYVGMLATVMNAISLQDGLERVGVETRVQTAIEMQEIAEPYIRRRAMRHLEKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVMKATKVDGVYDRDPNKFKEAKKYSSLTYQQVLSDEIAVMDSTAIALCKDNNIPIMVFDIFKKGNISRAVAGESIGSLIS
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSB_TERTT
Sequence: MKWLVAVLVVFVAMFQYRLWVGEGSIADVVRLEREIARQEADNERLRERNKQLAAEVDALKTGDDAIEERARSDMGMIKEGETFFMIIDDQ
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: RSMG_NEIM0
Sequence: MERKERLRAGIAAMGLDILETAQDRLLAYVDLLKKWNKTYNLTALRDEEKMIVHHLLDSLTLLPYIEGAQTMLDVGSGGGQPGIPAAVCRPDVQITLLDANTKKTAFLQQAVIELGLDNVRVVSGRVEAVSDVRADVITSRAFAELADFVSWTGHLLKDGGYWAAMKGVYPQGEIDRLPQDVCVEKVQRLDVPGLDAERHIAILRKR
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CGEE_BACSU
Sequence: MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQLHDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDMKLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADIIILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAKSLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT
What is the function of this protein?
May be involved in maturation of the outermost layer of the spore.
What are the official names of this protein?
Uncharacterized N-acetyltransferase CgeE.
Protein: RL19_VIBVU
Sequence: MSNIIKALEQEQMKQDLPKFAPGDTVVVQVKVKEGNRERLQAYEGVVIAIRNRGLHSAFTVRKISNGEGVERTFQTHSPVVDSIEVKRRGAVRRAKLYYLRERSGKSARIKEKLAKK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RL16_ACIB3
Sequence: MLQPKRTKFRKVHKGRNTGLAHRGSTVSFGSIAIKATERGRMTARQIEAARRTISRRIKRGGKIFIRVFPDKPITEKPLEVRMGNGKGNVEYWVCEIKPGKILYEIEGVNEDLAREAFALAAAKLPFKTTIVTRTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RS13_BORDL
Sequence: MARIAGIDLPNNKQLQIALTSIYGIGRSRALEICKKTGILPEKRAKDLDNEEVNKLRKIIESDYVVEGKLRSELAMSIKRLMDIACYRGLRHRKGLPLRGQRTKTNARTRKGKRKTVANKKIAAK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RL25_RICRO
Sequence: MSEILELEAESRTEFGTGAARALRRAGRVPAIIYGAGKTPVSISLEEKEITKYYRKPAFISQLINLTIDKKKYKVLPKAVELHPVTDIVRHVDFVFLEKKTQKMEVPVVYEGKERALGVKRGGYFNIVKRRVTLLCDVNNIPRNITIDVTNMPMATSLKSSKIELPKGCSFVTKKEFVLATIIGRRGAKTEAEGEQQAAEAGK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: NAC1_CANLF
Sequence: MLQLRLLPTFSMGCHLLAVVALLFSHVDLISAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVDNFLDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVAENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSALACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLYGQPVFRKVHAREHPIPSTVITIAEEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGILTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
What is the function of this protein?
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1700476, PubMed:1785844, PubMed:9486131, PubMed:17962412).  Contributes to Ca(2+) transport during excitation-contraction coupling in muscle.  In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum.  SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline.  Required for normal embryonic heart development and the onset of heart contractions (By similarity).
What are the official names of this protein?
Sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1, Solute carrier family 8 member 1.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
Protein: TATC_HALH5
Sequence: MNERDMSLMDHIAELRRRILIIVVFFVIALVVGFFLATPMITYLQGAPTAQDLPMNAFKLTDPLRVYMTFAFTSAFILVFPIILYQLWAFVSPGLHENERKATLAYIPIAFFLFLGGLSFAYFILFPFLIQFIGGLAERLHINELYGINEYFTFLFQITMPFGVLFQLPVVVMFLTRLGIVTPEFLRSVRKYAFFVLLVVAGFITPPELISHLMVTVPLLLLYEFSIWVSHLTYRKVQKLEKLRQEEYRQEEG
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
What are the official names of this protein?
Sec-independent protein translocase protein TatC.
What is the protein family that this protein belongs to?
Belongs to the TatC family.
Protein: FER1_SYNP2
Sequence: MATYKVTLITPDGEVSYDAPDDEYILDSAGDAGYDLPASCRAGACSTCAGKIVSGTVDQSEQSFLDDDQIEAGYVLTCIAYPQSDVTIETNKEEELY
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin-1, Ferredoxin I.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
Protein: WASH1_XENLA
Sequence: MPQNRSVESQAYSLPLILPDLRREEAIHQITDTLQHLQTVSNDIFSRILQRVETNRDQLQRINGRLSLAQAKIERLKGSKKAIKVFSSAKYPAPDRLQEYSSIFAGAKDGWSAKKQRHKIQSKHRPLDEQAVQEKLKYFPVCVNTRGQDEESAEEGLGSLPRNINSVSSLLLFNTTENLYKKYVLLDPLAGVVTRTNPALEGEDEEKLFDAPLSITKREQLERQTAENYFYVPDLGQVPEIDVPYSLPDLLGVADDLMYSADLGPGIAPSAPGVPIPELPTFTTEDITENSITDRQDGRLLPPPPPPPPPPPPPPPPEPSALSPPAPPPPPLSIPAPAKKGGSDPGDQGAVQGAPKEVVNPSNGRASLLESIRQAGGIGKANLRNVKEKKLEKKKMKEQEQVGATGGGGDLMSDLFNKLAMRRKGISGKVPAAGEASGDGPTGAFARISDTIPPLPPPHQASGDGDEDDWES
What is the function of this protein?
Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
What are the official names of this protein?
WASH complex subunit 1, WAS protein family homolog 1.
What is the protein family that this protein belongs to?
Belongs to the WASH1 family.
What are the subcellular locations of this protein?
Early endosome membrane. Recycling endosome membrane.
Protein: LGB2_PEA
Sequence: MGFTDKQEALVNSSWESFKQNLSGNSILFYTIILEKAPAAKGLFSFLKDTAGVEDSPKLQAHAEQVFGLVRDSAAQLRTKGEVVLGNATLGAIHVQRGVTDPHFVVVKEALLQTIKKASGNNWSEELNTAWEVAYDGLATAIKKAMT
What is the function of this protein?
Provides oxygen to the bacteroids.  This role is essential for symbiotic nitrogen fixation.
What are the official names of this protein?
Leghemoglobin Lb5-10.
What is the protein family that this protein belongs to?
Belongs to the plant globin family.
Protein: ACR30_BPD31
Sequence: MIAQQHKDTVAACEAAEAIAIAKDQVWDGEGYTKYTFDDNSVLIQSGTTQYAMDADDADSIKGYADWLDDEARSAEASEIERLLESVEEE
What is the function of this protein?
Allows the phage to evade the CRISPR/Cas system type I-F.
What are the official names of this protein?
Anti-CRISPR protein 30, Gene product 30, gp30.
Protein: MCM2_SCHPO
Sequence: MDSFRKRGRRDSESLPFESENSSLGATPLSLPPSSPPPEFSDEAAEALVEEDIEDLDGEALDVEDEEGEDLFGEGMERDYQQNLELDRYDIEELDDDNDLEELDIGARRAVDARLRRRDIELDAAAGRTKPAAFLQDEDDDLDSNLGTGFTRHRHRIYDEYSPNVGALDESGELPLESIADVKADSIAEWVTLDPVRRTIAREFKNFLLEYTDENGTSVYGNRIRTLGEVNAESLMVNYAHLGESKPILAYFLANAPAPIFRIFDRVALEATLLHYPDYERIHSDIHVRITNLPTCFTLRDLRQSHLNCLVRVSGVVTRRTGLFPQLKYIRFTCTKCGATLGPFFQDSSVEVKISFCHNCSSRGPFVINSERTVYNNYQRITLQESPGTVPSGRLPRHREVILLADLVDVAKPGEEIDVTGIYRNNFDASLNTKNGFPVFATIIEANHISQLDGSGNTDDDFSLSRLTDDEEREIRALAKSPDIHNRIIASMAPSIYGHRSIKTAIAAALFGGVPKNINGKHKIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFATGQGASAVGLTASVRKDPITNEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCTIIAAANPIGGRYNTTIPFNQNVELTEPILSRFDILQVVKDTVNPEIDEQLANFVVSSHIRSHPAFDPNMDVLKKVPTETGIDAKPIPQDLLRKYIHFAREKVFPRLQQMDEEKISRLYSDMRRESLATGSYPITVRHLESAIRLSEAFAKMQLSEFVRPSHIDKAIQVIIDSFVNAQKMSVKRSLSRTFAKYLI
What is the function of this protein?
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity).  Plays an important role in DNA replication.
What are the official names of this protein?
DNA replication licensing factor mcm2, Cell division control protein 19, Minichromosome maintenance protein 2.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TXHM3_HERML
Sequence: GCIAKNKECAWFSGEWCCGALSCKYSIKRNLKICV
What is the function of this protein?
Gating-modifier toxin that inhibits mammalian and insect voltage-gated sodium channels.  It shifts the voltage dependence of channel activation to more positive voltages.  It shows potent activity on Nav1. 4/SCN4A (IC(50)=103 nM), Nav1. 5/SCN5A (IC(50)=268 nM) and Para/DmNav1 (IC(50)=555 nM) and lower activities on Nav1. 2/SCN2A (IC(50)=1447 nM) and Nav1. 6/SCN8A (IC(50)=3504 nM) (PubMed:25352595).  In addition, at a concentration of 1 uM, the toxin inhibits 90-100% of sodium current through Nav1. 2/SCN2A, Nav1. 4/SCN4A, Nav1. 5/SCN5A, Nav1. 6/SCN8A and Para/DmNav1 channels, when the voltage of maximal activation of the channel in control conditions is applied (Ref. 1).  It binds to the S3-S4 helix-loop-helix motif in the voltage-sensing domain of repeat 1 (shown on hNav1. 4/SCN4A) (PubMed:29636418).  The toxin is amphiphilic and binds to both neutral and negatively charged lipid vesicles with high affinity (PubMed:29636418, PubMed:25352595).  The hydrophobic face lies on the opposite side to the hydrophobic faces of classical gating modifiers (PubMed:25352595).
What are the official names of this protein?
Mu-thomitoxin-Hme1c, Mu-TMTX-Hme1c, Neurotoxin Hm-3.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 07 (Beta/delta-agtx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLN1B_ECOLI
Sequence: MSAEHVLTMLNEHEVKFVDLRFTDTKGKEQHVTIPAHQVNAEFFEEGKMFDGSSIGGWKGINESDMVLMPDASTAVIDPFFADSTLIIRCDILEPGTLQGYDRDPRSIAKRAEDYLRSTGIADTVLFGPEPEFFLFDDIRFGSSISGSHVAIDDIEGAWNSSTQYEGGNKGHRPAVKGGYFPVPPVDSAQDIRSEMCLVMEQMGLVVEAHHHEVATAGQNEVATRFNTMTKKADEIQIYKYVVHNVAHRFGKTATFMPKPMFGDNGSGMHCHMSLSKNGVNLFAGDKYAGLSEQALYYIGGVIKHAKAINALANPTTNSYKRLVPGYEAPVMLAYSARNRSASIRIPVVSSPKARRIEVRFPDPAANPYLCFAALLMAGLDGIKNKIHPGEAMDKNLYDLPPEEAKEIPQVAGSLEEALNELDLDREFLKAGGVFTDEAIDAYIALRREEDDRVRMTPHPVEFELYYSV
What is the function of this protein?
Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I beta, GSI beta.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IGF1_CHICK
Sequence: MEKINSLSTQLVKCCFCDFLKVKMHTVSYIHFFYLGLCLLTLTSSAAAGPETLCGAELVDALQFVCGDRGFYFSKPTGYGSSSRRLHHKGIVDECCFQSCDLRRLEMYCAPIKPPKSARSVRAQRHTDMPKAQKEVHLKNTSRGNTGNRNYRM
What is the function of this protein?
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.  Acts as a ligand for IGF1R.  Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways.  Binds to integrins.  Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.
What are the official names of this protein?
Insulin-like growth factor I, IGF-I, Somatomedin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.