PharMolix/UniProtQA huggingface dataset:
Protein: REX_LACLC
Sequence: MTDHKPSKSLPKATAKRLPQYYRLFKSLVEENVTRTNSQLISEKIGVDAATIRRDFSLFGELGRRGYGYETKVLRDFFGELLGQDQETHIALIGVGNLGRALLHYQFQDRNKMRITQAYDISGNPLVGTQTDDGIPIYNISDLEKNVKKSDIKTAILSVRKENAQEVVDTLVKAGIKGFLNFAPIRLKVPSDVVVQSIDLTKELQTLLFFMGAQEE
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_CHLTE
Sequence: MPTLKDIRIRLKGVKSTQQVTKAMKMVAAAKLRRAQDRAIQARPYAGKLKEMLASLSTKVDTSVNPLLSPREEVNNVLVILVTSDRGLCGGFNANIIKMAQRLIHEEYAALHAKGGVTMICAGTKGTEFFRKRGYKLAAAYPGVFQNLSFDSAREIADKASKMYLSGEVDRVVLVYNEFKSVLAPNLRTEQLLPITPEGGDAKTASSEYLYEPSPAAIIDELVPKHLNTQLWRVMLESNAAEQAARMAAMDSATENAKELIRVLNISYNRARQAAITKELSEIVAGADALKQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GATB_BURP0
Sequence: MTQWEVVIGLETHAQLSTVSKIFSGASTQFGAQPNTQACPVDLALPGVLPVLNRGAVERAIRFGLAIGATVAPRSVFARKNYFYPDLPKGYQISQYEIPVVQGGQITIQVPANEKAGKQAYSKTVNLTRAHLEEDAGKSLHEDFAGMTGIDLNRAGTPLLEIVTEPEMRSAAEAVAYAKALHGLVMWLGICDGNMQEGSFRCDANVSVRPVGQEKFGTRAEIKNLNSFRFLEDAINYEVRRQIELIEDGGEVVQETRLYDPDKRETRSMRSKEDAHDYRYFPDPDLMPLVIGADWIARVKGEMPELPAAMQQRFVEQYGVSAYDAGVLTSTKAMAEYFEALVAKAGAANAKLAANWLMGDVSSQLNRDGIDIDACPVSAAQLALVLQRIADGTISNKIAKEIFVTIWDEKAADEGAADRIIEAKGLKQISDTGALEAIIDEVLAANAKSVEEFRAGKDKAFNALVGQAMKATKGKANPQQVNELLKKKLG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: DNAJ_CHLAB
Sequence: MDYYDVLGVSKTASPEEIKKSYRKLAVKYHPDKNPGDAEAEKRFKEVSEAYEVLSDPQKRESYDRYGKDGPFAGAGGFGGAGMSNMEDALRTFMGAFGGELGGSGSFFEGLFGGLGEAFGMRGDPAGARQGASKKVHITLTFEEAARGVKKELLVSGYKTCETCSGSGASSKQGIKCCDRCKGSGQVVQSRGFFSMASTCPECGGEGRMITDPCSSCRGQGRIKDKRSVHVQIPAGVDSGMRLKMEGYGDAGQNGAPAGDLYVFIDVEAHPVFERRGDDLILELPIGFVDAALGMKKEVPTLLKEGACRLTVPEGIQSGTILKIKNQGFPNVHGRGRGDLLVRVSVETPQNLSEEQKELLRKFAATEKAENFPKKRSFLDKIKGFFSDLTV
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYSY_THEKO
Sequence: MIKAAVVGASGYIGGELVRLLAMHPEVEITAITSRRFAGQKVHKVHPNLRGLDLRFTNTKEFDADVIFLAVPHGTSMEIIDDYLGSAKIIDMSADFRLREDLYREYYGEHKRPELIEEFVYGLPELHRKEIRKAELVANPGCNATATILALYPFRELTDEAIVDLKVSSSAGGRRENVASIHPERSHVVRVYKPYHHRHEGEVIQETGVKAAFTVHSVDIIRGLLATIYFRFEGSTRELLRKLLVYKDEPFVRLVTDKGGLQRFPDPKYVIGSNFADIGFAHDEENSRAIVLSAIDNLIKGGSGQAVQNMNLMFGLDERTGLNYYPVYPV
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.
What are the official names of this protein?
Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_SYNE7
Sequence: MAAPLAQLRDRFQAALAASFGPEWAATDPLLVPATNPKFGDYQSNVAMSLAKQLGQPPRAIAETLVQNLNLADLCEPPAIAGPGFINFTLQPSYLVAQLQQLQTDERLGIQPVSPPQRVIVDFSSPNIAKEMHVGHLRSTIIGDSIARVLEFQGHEVLRLNHVGDWGTQFGMLIAFLQEQYPQALSQPDALDISDLVAFYKQAKARFDEDPSFQETARQRVVDLQSGEATARQAWQLLCDQSRREFQKIYDRLDIQLEERGESFYNPYLPAIVEDLRRLGLLVEDQGAQCVFLEGFQNKEGQPLPLIVQKSDGGYNYATTDLAALRYRLGQDQAQRIIYVTDSGQANHFAQVFQVAQRAGWLPAAAQIEHVPFGLVQGEDGKKLKTRAGDTVRLRDLLDEAVDRARTDLTTRIAAEERSETPEFIEAVAQAVGLGAVKYADLSQNRNSNYIFSFDKMLALQGNTAPYLLYAYVRIQGIARKGGIDFAQLDPVAAVLTEPTERSLAKQVLQLGEVLDEVARDLLPNRLCSYLFELSQTFNQFYDRCPILNAEEPQRTSRLLLCDLTARTLKLGLSLLGISVLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_BURVG
Sequence: MQIILLEKVANLGNLGDIVKVKDGYARNFLIPNRKARRATKEAIAEFEVRRAELEKIAAEKLAASQAVGEKLNGQAFEVTQKSGVDGRLFGSVTNGDVAELLKKAGFEVEKLQVRMPEGPLKMIGEHVVQVALHTDVVVDVTINVIGDHA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: GPMI_HAHCH
Sequence: MTAKRKPTALLILDGWGYREGKDSNAIANANTPFWDQISSQNPHVLIHTSGMAVGLPEGQMGNSEVGHMNLGAGRIVYQNFTRITKDIEDGVFAQNPAISSAIDKAVSNGKAVHLLGLLSPGGVHSHEDHILAACKVARERGADKVFVHAFLDGRDTPPRSAQPSLERTDKLLKELGCGRVASIIGRYYAMDRDNRWDRVQAAYDLLTLGEAPYHAESAVQALTAAYERGEDDEFVKATLIKGSSDNDAVISDGDAVIFMNFRADRARELTRCFVEQDFDGFQRNKLPKLADFVMLTEYSANIHTACAYPATELTNSIGEYMATLHKTQLRIAETEKYAHVTFFFSGGKEALFEGEERILIPSPDVATYDLKPEMSAPEVTDKLVEAIKSGKFDLIVCNYANGDMVGHSGVYDAAMKAAECIDQCLKRIAEALNEVGGQCLITADHGNAEQMVDENGQPHTQHTTGPVPLIYIGPKNISLKEDGRLCDIAPSLLDLMELEKPREMTGESLIVQN
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: RS13_BACFR
Sequence: MAIRIVGVDLPQNKRGEIALTYVYGIGRSSSAKILDKAGVDKDLKVKDWTDDQAAKIREIIGAEYKVEGDLRSEVQLNIKRLMDIGCYRGVRHRIGLPVRGQSTKNNARTRKGRKKTVANKKKATK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RL40_LEIMA
Sequence: MQIFVKTLTGKTIALEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEEGRTLSDYNIQKESTLHLVLRLRGGVMEPTLVALAKKYNWEKKVCRRCYARLPVRATNCRKKACGHCSNLRMKKKLR
What is the function of this protein?
Component of the 60S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-60S ribosomal protein L40.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [60S ribosomal protein L40]: Cytoplasm.
Protein: CHED_BORT9
Sequence: MLNHFNFKLKRDVTIIVPGEAFVSNDRVISTILGSCVSVVLYDGVRRLIGVNHYVLVKSDSVVDVLQKGRYGVYAIPMLIDAMIENGASKSNLKAKLFGGANFMAKGTIRVGVENSEFAVNSLTKYGIPVVAQDFDQSKSRKIFVFPENFKVVVEYPDGAKIF
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: SECB_NEIG1
Sequence: MSEELQPVFSIERLYVKDLSLEVPHAPQIFLEQGDPEVDMRVSTGSQKLEDGYYDVDVTVTVTAKLDNERTMFLNEVTQSGIFRLENIPEEDVQLLLGVACPNILFPYAREAVSGTVTRAGFPPVLLAPINFEAIYQQQQEAEAAGA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_SALG2
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILQQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRSDLLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHAEDIDQKSLQEAVMEEIIKPILPSEWLNTSTKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPAEQLILLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGRENFPWEKTDKAQLLRDAAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_RALPJ
Sequence: MSGNTLGLLFSVTTFGESHGPAIGAVIDGCPPGMTLSAEDIQPDLDRRKPGTSRHVTQRKEEDLVEILSGVYEGKTTGTPICLLIRNTDQRSKDYSNIAETFRPGHADYTYWHKYGIRDPRGGGRSSARLTAPTVAAGAVAKKWLREKFGIEIHGFMSQLGDIHIPFMDWNEVPNNPFFAPNAEIVPELETYMDALRKDGDSVGARIEVVATGVPVGWGEPLFDRLDADIAHAMMGLNAVKGVEIGAGFHAVSQRGSEHGDELTPEGFVGNNAGGILGGISTGQDISVSLAIKPTSSIRTPRRSIDKAGDPAVVETFGRHDPCVGIRATPIAEALLALVLIDHALRHRAQCGDVSVETPAIPAKAS
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: BCHL_ACIRU
Sequence: MNDISTVNKLAERIGGSSCSTSCGDGEGSLQVALDPHIKITGAKVFAVYGKGGIGKSTTSSNLSAAFSRLGKRVLQICRDRGADATI
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP (By similarity).
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: SSRP_DESRM
Sequence: MAAKATSEKGFKTITDNRRARHEYHVIETYEAGIALSGTEVKSLRAGKANLQDAFARVENGEMMLYNLHISPYEQGNRFNHEPKRTRRLLMHKQEILRLYGKVREKGLALIPLKVYFNPRGKVKVQLALAQGKKSYDKRHDIAARDAKRDMDRAMRERQKM
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: LPTD_PSESM
Sequence: MALKSPAFRKKFPLLVTGSLLAMQPLATQFVVAAEQYDCSVSASGAWNCAPKSTAAAVELPPRPVHSTASVSSNGTVTSESSSSGEQVAGPQLVTEAKGKGLKSRSADYSHLDWVPREKLTAAQLAETGPYCSGAYVEPIRPGMDDKTPMKDAPMFVGAKASRYEQEAQVATLAGDVVLRQGSMQVQAQEAALHQAENRGELNGDVRLRDNGALIVGDKAELQLDTGEARVDNAEYVLHKSNIRGNALYAKRAENAIIRLKDGTYTTCEPNSNAWTLKGNNITLNPATGFGTATNVTLRVKDIPVLYTPYIYFPIDDRRQSGFLPPTIAAGGDNGFTLVTPYYFNLAPNYDATLYPRYMADRGLLMEGEFRYLTKGSEGQFGGAYLNDENDDRKLQSDYDKTRWMINWHHKGGLDTRWLTQVDYTDISDPYYFQDLETDQIGVKRTDFLNQQGSLTYRGDSYSAVFNAQAYKLATVANVTPYNRLPQLTLNGTLPYNPEGLKFDYQTEAVRFDRDLRTGTFVDENGNFESRLDNNISGLDRANGDRLNLAPSVSLPMNWSYGFLTPKVKYVYTQYDLSLDGTGKSQLAASGGTFDSSVNRSVPIFSVDSGLYFDRNTNWFGKDYRQTLEPRLFYLYVPEKDQTDIPAFDTSESTFSYSSLFRDNRFTGSDRIGDENKLSLGITNRWIEDNGFERQRFAIGQAIYFSDRKVQLPGVSFADRDDAKANVSPYALEYEYRFNRDWRFNSDFNWDPDSKSTRSGSAMFHYQPEAEPNKIVNFGYRYRNDQIRYDESTGRWIVGGGDYGRPGDPNYVKDYYKIQQHDFSVIWPIVPQWSLISRWQYDYNRERTIEAFGGFEYDNCCWKMRLVNRYWIDYDEFSQAAPQNEKGDRGIFLQIVLKGLGGVTGAKVDSFLDKGIQGYREREDQAF
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: TRPF_STRMU
Sequence: MTKVKICGLSTQEAVTAAVSSGADYIGFVFAKSKRQVSLEQAQKLAKMIPEKVKKVGVFVSPTLEELKIAIKTVPLDLVQVHGDYDEDLQTDFSVPLIRAVQIKKGKENLTSKADYLLFDAPIAGSGETFDWQQLETEQLQKPFFIAGGLTSDNVKECIEHFAPYAVDVSSGVETNGRKDIEKIKRFIESVKK
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: Y1648_STREM
Sequence: MSTAIWILLIIVALTAGLFGGIFIARKQIEKEIGEHPRLTPEAIREMMSQMGQKPSEAKIQQTYRNIVKQSKAAMTKGKK
What are the official names of this protein?
UPF0154 protein Sez_1648.
What is the protein family that this protein belongs to?
Belongs to the UPF0154 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: NPRL3_DROME
Sequence: METNVNPLAVILVYFDSKGDRLLYRYPYQTLGQTEVANDEQRKSRKRNPYAVANTDDLLQTPTHLGAAKSQGQLQGFADEVLSALFAVKPQLCNQKFELKLNDVRFVSHPTLIPQKEQRSGPMAKQQMLINIVFALHAQASYSIVKCYHELSKRLGLALKFEEQRSGYLTEQTAQMARTHDEQQQQPLERTLELIAERCSLAQALRSIFHDLCTTGLLSTSLNHNLTLCFCLPAKAHQLHKKGSMVDPETIDRCLRALKPYHGMLLLVDFAELLDCVPPTGARMLWQLVDVYDPLISLQSMSSNADLSIEHVYKLVSHLVYWAKATIIYPLCETNVYVIAPDAPLHTKSHLVEKFSARFAGMSLFEVISDFSLPTSIGHLTTPLQQPARQGILAQMVIWMLQHHLLMQLHTYVQFMPSEDEFGDSASCSNHLRDAISDEEGDQEPDADELHGSMLSMSSHPLPVPAVLVGGHRREASEDHSSLASDNIAVQPSSSHKSNFSITASMSTDNCDSLDSMEDEQKLKELLQVFSDADRAAIRRIPASANVDDLSLLVKLYQMGYFKSEHHLEEIMYFENLRRSQLLQLLDKFRDVLIIYETEDPAIASMYNTK
What is the function of this protein?
An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823, PubMed:25512509).  The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:27166823, PubMed:25512509).  The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy (PubMed:23723238, PubMed:27166823).  In addition, this inhibition of TORC1 is necessary to maintain female fertility under normal conditions and during periods of nutrient stress (PubMed:24786828, PubMed:27672113, PubMed:25512509).  GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509).  After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509).  At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:25512509).
What are the official names of this protein?
GATOR complex protein NPRL3, Nitrogen permease regulator 3-like protein.
What is the protein family that this protein belongs to?
Belongs to the NPR3 family.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome. Note=Localizes primarily to the autolysosomes during amino-acid starvation (PubMed:24786828).
Protein: SPAG4_MOUSE
Sequence: MRRSPRSGSAASSHNHTPNFYSENSNSSHSATSGDSNGRRSAGPELGEPEGRRARGSSCGEPALSPGMPGGDTWAGSSRPKLAPRSHNGQTACGAATVRGGASEPSGSSVVLEEQLNLLPILDLRQEMPTPRVSKSFLSLLFQVLSMVLSLAVDGLVCVCREICSIRFLFTAVSLLSIFLAALWWGLLYLIPPLENEPTEMLTLSQYHHRVHSQGQQLQQLQAELNKLHKEVSSVRAAHSERVAKLVFQRLNEDFVRKPDYALSSVGASIDLEKTSSDYEDQNTAYFWNRLSFWNYARPPSVILEPDVFPGNCWAFEGDKGQVVIRLPGHVQLSDITLQHPPPTVAHTGGASSAPRDFAVYGLQADDETEVFLGKFIFDVQKSEIQTFHLQNDPPSAFPKVKIQILSNWGHPRFTCLYRVRAHGVRTSEWADDNATGVTGGPH
What is the function of this protein?
Involved in spermatogenesis.  Required for sperm head formation but not required to establish and maintain general polarity of the sperm head.  Required for anchoring and organization of the manchette.  Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex.  May anchor SUN3 the nuclear envelope.  Involved in maintenance of the nuclear envelope integrity.  May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail.
What are the official names of this protein?
Sperm-associated antigen 4 protein, Outer dense fiber-associated protein SPAG4, SUN domain-containing protein 4.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. SUBCELLULAR LOCATION: [Isoform 1]: Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus envelope. Nucleus inner membrane. Cytoplasm, cytoskeleton, flagellum axoneme. Note=In spermatids, isoform 1 is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm (By similarity). Conflictingly is not found in axoneme but only associated with the manchette where cytoplasmic microtubules contact the nuclear envelope. Localizes at the posterior lateral side of round and elongating spermatids (PubMed:26621829).
Protein: NIFS_BACSU
Sequence: MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHILEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIHNCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHLSSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPWKPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIRSLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSETMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGRQQA
What is the function of this protein?
Catalyzes the removal of elemental sulfur from cysteine to produce alanine (By similarity).  Seems to be required for NAD biosynthesis (PubMed:8444804).
What are the official names of this protein?
Putative cysteine desulfurase NifS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
Protein: RS7_AYWBP
Sequence: MSRKGHIKKRDVQPDPIYNSKLVTKTINTIMEDGKKGKAQTIFYQALKQVKTITNRDPIEVFHEALNNIMPVLEVRTRRVGGQNYQVPSEVRPERRHSLGLRWLVKYTKERNEKTMEERLAKEIVDASLGNGVSVKKREETHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: OMPL_PHOPR
Sequence: MNKKLIALAVAAASISSVATAAEVYSDETSSLAVGGRFEARAVLADVNKDENVTNTASSEVSDKSRVRINVAGKTDITEDFYGVGFFEKEFSSADSDNDETRYAYAGVGSQYGQLVYGKADGSLGMLTDFTDIMAYHGNEAGNKLAAADRTDNNLSYVGSFDLNGDNLTVKANYVFGGSDENEGYSAAAMYAMDMGLGFGAGYGEQDGQSSKNGNEDKTGKQAFGAISYTISDFYFSGLYQDSRNTVVNNDLIDESTGYEFAAAYTYGKAVFITTYNFLEDSNASGDASDLRDSIAIDGTYYFNKNFRTYASYKFNLLDANSSTTKAQASDEFVLGARYDF
What is the function of this protein?
Forms pores that allow passive diffusion of small molecules across the outer membrane.
What are the official names of this protein?
Porin-like protein L.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: MNTH_SALPA
Sequence: MTDNRVENSSGRAARKLRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLLLFVAAAYIVELFFSQPDMAQLGKGMVIPALPNPEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGTRQQRYSATKWDVAIAMTIAGFVNLAMMATAAAAFHFSGHTGIADLDQAYLTLEPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFVRFHIPLWVRRTITMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSNATLMGELVNTRRVKQIGWIIVVLVVALNIWLLVGTVMGLS
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.