PharMolix/UniProtQA huggingface dataset:
Protein: RGRF2_DANRE
Sequence: MQKSVRYNEGHALFLSVIARKEGTKRGYLSKKTTENSKWHEKFFALYQNVLFYFDTDQSARPSGIYLLEGCTCERVPALKVSTVGKDALDKLQYFLVVFGHDGQKPLELRTEEESDCDEWVEAIQQASYSDIIIEREVLMQKYIHLVQIVETEKVAANQLRTQLEDQDTEIERLKAEIIALNKTKERMRPYHVFQEEEDPDIKKIKKVQSFMRGWLCRRKWKIIVQDYICSPHAESMRKRNQIVFNMVEAETEYVHQLSILVNCFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYESNAACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFVRQGSLIQLPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKQGGVLSLIECTLIEEPDANDEDAKNSGQVFGHLDFKIVVEPSDAPAFTVVLLAPSRQEKAAWTSDISQCIDNIRCNGLMTSVFEENSKVTVPHMIKSDARLHKDDVDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTATVVMEKLADIYKKPFTSIPVRSLELFFATNQNNRSGDHVNDKSPRLCRKFSSPPPLSISSRTSSPVRTRKLSLNSPIGSKVGILDLSTTSSSAASSPTSANPTISPPPSNNNNNSKPPLDLSRGQSPSSPEQSPGALDDNAEVPRIDALCGKLRRSIRRAVLESVSLDKFIPESPQASEPGEISPCRSPSTPRHLRYRQSGVQTAENSRCSVSPASAFAIATAAAGHSSPPVFNNSERTCDKEFIIRRAATNRVLNVLRHWVSKHSQDFEMNGELKMGVICLLEEVLRDPDLLPQERKATANILSALSQDDQDDAQLKIEDILQMAECPKAECFESLSAMEIAEQITLLDHIVFRSIPYEEFLGQGWMKTDKTERTPYIMKTSQHFNDMSNLVASQIMSHTDVGSRAGSIEKWVAVADICRCLNNYNGVLEITSALNRSAIYRLKKTWAKVCKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPCVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTPYRIEHQPKVTQYLLDKTLIMDEDTLYDLSLKIEPRLPA
What is the function of this protein?
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and rac1 through the exchange of bound GDP for GTP.  May function in synaptic plasticity.
What are the official names of this protein?
Ras-specific guanine nucleotide-releasing factor 2, Ras-GRF2, Ras guanine nucleotide exchange factor 2.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: CK5P3_CAEEL
Sequence: MSDDLPIDIHSSKLLDWLVSRRHCNKDWQKSVVAIREKIKHAILDMPESPKIVELLQGAYINYFHCCQIIEILRDTEKDTKNFLGFYSSQRMKDWQEIEGMYKKDNVYLAEAAQILQRLAQYEIPALRKQISKMDQSVTDAIRKHSEYGKQAEDGRKQFEKEISRMQLKGVHLRKELLELAADLPAFYEKITAEIRKISAARDYFQAFRDYMSLGAAPKDAAPILPIIGLIGERGLDVTTYEWKYNQKPDKVEKPNFEMLLTAAEDSDEIDFGGGDEIDFGIAAEDDAVIDFSAVVDLVADDTGAVGEAIASGQDALHLLENSEAQKAVKHELIELLAFLSMRLDDETRETTADVLIRGAEKRPDGVAAVTEKRLKTWITEVEGILKELENPQKVHLFKIRGSPQYVEQVVEELEKKRDMEHRYKRLQTLMTENQETARQSVTKSNVELKTIVESTRVLQKQIEAEISKKYNGRRVNLMGGINQALGGN
What is the function of this protein?
Potential regulator of CDK5 activity.
What are the official names of this protein?
CDK5RAP3-like protein.
What is the protein family that this protein belongs to?
Belongs to the CDK5RAP3 family.
Protein: NUOC_MYCMM
Sequence: MSSPDQNPSDAAGQTGSSNEEVVDVRRGMFGVKGTGDTSGYGRLVREIVLPGSSPRPYGFYFDEIADRLAEALNRDGVEFEDAIEKVVVYRNELTLHVRREALLRVAQSLRDEPELRFELCLGVNGVHYPHETGRELHAVYPLQSITHNRRLRLEVSAPDSDPHIPSLYAVYPTNDWHERETYDFFGIIFDGHPSLTRIEMPDDWQGHPQRKDYPLGGIPVEYKGAQIPPPDERRGYN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GRDH_PEPAC
Sequence: MKKAILYLNQFFGQVGGEDKADYEPEIINGQVGAAMMLNGVLEGAEVTHTIICGDNFMGTYKDEAVSRIMGFLEDKEFDIFLAGPAFQAGRYGVACGEICKVVKEKYNVPVVTSMHVENPGVQMFKKDMYVMIGGNNAGRMRQDMSAMAKVANKIIAGEKIGPADEEGFFPRGKRHQHWREDGKPASERVVDMLLKKLSGEEFQTELPIPKSDRVEIAAPIKDLSKATIAVVTTGGIVPVDNPDRIQSASATRWGMYDVTGLERLEGGVYKTIHAGFDPAAADADPNVIVPLDALRAYEKEGKIGKVHEYFYSTVGTGTTEAEAARMAKEIVVKLKQGGVDGVIMTSTUGTCTRCGATMVKEIERAGFPIVQMCNLIPVASTVGANKIVPTISIPYPLGDPSTSKEQQWKLRYHRVGTALDALTVDVQEQTIFKVKI
What is the function of this protein?
In the first step of betaine reductase, the substrate is bound to component PB via a Schiff base intermediate.  Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine.  By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state.  Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.
What are the official names of this protein?
Betaine reductase complex component B subunit beta, Selenoprotein PB beta.
What is the protein family that this protein belongs to?
Belongs to the GrdB/GrdF/GrdH family.
Protein: VAMP2_MOUSE
Sequence: MSATAATVPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST
What is the function of this protein?
Involved in the targeting and/or fusion of transport vesicles to their target membrane (PubMed:9430681).  Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters.  Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (PubMed:15475946).  Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity).
What are the official names of this protein?
Vesicle-associated membrane protein 2, VAMP-2, Synaptobrevin-2.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
Protein: DPO4_XANOM
Sequence: MRKIVHVDMDAFYASVEQRDDPGLRGKPVVVAWRGARSVVCAASYEARTFGIRSAMPAVRAERLCPNAIFVPPDFVRYKAVSRQVREIFHRHTDLVEPLSLDEAYLDVTQAKTGMQLATEIAQLIRTQIREETELTASAGIAPNKFLAKIASDWRKPDGQFVIAPSRIDAFLLPLKVNRIPGVGKVMDGKLAALGIVTVADLRLRPLEELQAHFGSFGQSLYRRARGIDERPVEPDQDVQSVSSEDTFSEDLALDALDTHILRLAEKTWLATRRTERIGRTVVLKLKTSNFRILTRSCTPEQPPVSQEALAQIALALTRRVELPAQTRYRLVGVGLSGFSNVEEGAVQGQLFGEIPQAE
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_PROM0
Sequence: MKEKIISEISLDLVFQCNDFSQFSNKLKDTNTHLIFESIFWEKVFLSWINTILKKEDYELPNYIFEKKSFSLGLQIISNQEIASLNKKWMQKNGPTDVLSFPIISDESLNNLDHIELGDIFISLEMALEQSYEYKNSIYREMIWLASHGFLHLLGWEHNNEHDLENMLNFQEYLIKKLD
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTF3_CALRI
Sequence: IQSTSMDQGSLTEDSMNSFIRTLIQAGIWKNKVPKQTARTKDGMQTTVKRTKAEAEAVASEGTRLGFQPVVLVDAELLRQQRRFSSPRVLLSENTPLEPPPLYLMEEPAVLNRTSRRKRYAEGKSHRGEYSVCDSESRWVTDKSSAVDIRGHQVTVLGEIRMGPS
What is the function of this protein?
Seems to promote the survival of visceral and proprioceptive sensory neurons.
What are the official names of this protein?
Neurotrophin-3, NT-3.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: CPXP_ECOLI
Sequence: MRIVTAAVMASTLAVSSLSHAAEVGSGDNWHPGEELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSELETMHRLVTAENFDENAVRAQAEKMANEQIARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQLRDVTQWQKSSSLKLLSSSNSRSQ
What is the function of this protein?
Acts as an auxiliary protein in the Cpx two-component envelope stress response system, helping modulate the Cpx response systems response to some inducers (PubMed:25207645, PubMed:16303867).  Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the Cpx envelope stress response in the absence of inducer; overexpression decreases Cpx pathway activity (PubMed:16166523, PubMed:21317318).  Some periplasmic stimulii (shown for P pili subunit PapE and probably 0. 3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway (PubMed:16166523, PubMed:16303867).  Aids in combating extracytoplasmic protein-mediated toxicity (PubMed:9473036, PubMed:16303867, PubMed:21239493).  Overexpression leads to degradation by DegP of misfolded P pili subunits in the periplasm (tested using PapE) (PubMed:21239493).  Inhibits autophosphorylation of CpxA in reconstituted liposomes by 50% but has no effect on phosphatase activity of CpxA (PubMed:17259177, PubMed:21239493).  Has mild protein chaperone activity (PubMed:21317898, PubMed:21239493).
What are the official names of this protein?
Periplasmic protein CpxP, ORF_o167, Periplasmic accessory protein CpxP.
What is the protein family that this protein belongs to?
Belongs to the CpxP/Spy family.
What are the subcellular locations of this protein?
Periplasm.
Protein: VPS10_PARBP
Sequence: MILRRLVLAGSLLLATAFTSAKKADSPIITATRFDHEPINLFYFGDSDVVMLQDIKNGDVYVSRDAGVKWDMVNLDGLKGQALSLWSHPTDRTKAYILGKAGKHWVTNDQAVSWHEFSADVEFFQSLFPLVFHGKDSDRVLLQGHKCVGRDCKEVTYYTTDGFKTVDILIENARGCNWAVSTPIFGDGLNLSKEVNDRIFCIVPGLQSPWSDYNRLLYSDRFFKQDSGTEAPLDSGRAVSGVVRTASVKKYLLAAAKSARTSELALYVTDDGSQWHRAEFDGQRVEEDAYTVLESTNYSIQIDVVAETPSAPMGTLFTSNSNGTYFTRNIDHTNRNGLGFVDFEKIATIQGIILVNTVKNWEDVEMSALVEKKIISQISFDDGRTFQPLKAGKHDLHLHSVTHLSNSGRVFSSPAPGLVMGVGNTGGHLKDYYDGDLYVSDDAGITWRKALDEAHKYEFGDQGSVIVAVFDEGRTGKISYSLNHGKDWKEASLPDGIKIRARILTTMPDSTGLKFLLVGSSKRDSDVEHYVISISFTDMEERTCGKDDFETWPARLNEKNEPDCLMGHKQFYQRRKADVDCFIKKKFQEPVPQFEPCKCTVEDFECDFNFIRSTDGKSCVPARSLPVPEGACKKPNDKYMGSSGFRLIPGNACIREGGVELDKQIERVCTDTLTVPVSGEIVVQKTFFTADNYKGYFYLERKDSSNGDDETVIMITSELQIYITRDHGKNWKEIFPGETITRIVPHQYFDDVAYFLTNSGDGWYTLDRGENFRKFKAPIPPNQDKLPVLSFHPERRDWLIWTGAEECKTRGPQCHSVAYYSTNHGSEWHFLMQYVRRCEFIKREARGSSNNLVFCEQFENENPLNHHLQLLSTDDWFSEKKVHYNNILDFATMQEFIIVAVRGEKPEDSLSVGVSVDGETFAYADLPANVQIPVQRAYTVLESRTHAAFLHVTVNNVEDHEYGSIIKSNSNGTSYVLSLSAVNRNTYGYADFEKMQGMEGVAMANVVGNVADVEKGAAKKYRTMITHNDGAEWALLSPPSKDSEGRDYSCSTKGGKPTDKCALHLHSYTERADPRDTYSSPSAIGVMLGTGNVGEYLTLKSDADTFITRDGGITWQEVRKDRYQWEFGDSGSIIVIVPEARPTKTLFYSLDEGKSWKEFQFTEVEMLIRDISTVPSDTSRNFLLWGNEVGNGKKPGVAAVNIDFSNLKERHKQCVLNEEKPEADDYYLWEPMHPFQPNGCLFGHRAKYHRKRPDRDCFIGRELQHLDSIGDICECTRSDYECDYNYEPQIDGTCAPVPGLKPLDPKLICTEDPKAVEWYEPTGYRRIPLTKCEGGKQLHHIIPHACPNKEEEFLKKHPGLRGVGLFFVIMSPIGLAAAIGYYVYTRWDGKFGRIRLGDTGSGGFFASDSLLVSIPVAIVAGVVAVATALPLLASSLWRSVRGYARVPGGSSSQRVYSSRAAFAAQRADYAGVVDDEDELLGAEDFDEEENDDRGQV
What is the function of this protein?
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.  Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
What are the official names of this protein?
Vacuolar protein sorting/targeting protein 10, Carboxypeptidase Y receptor, CPY receptor, Sortilin VPS10, Vacuolar carboxypeptidase sorting receptor VPS10.
What is the protein family that this protein belongs to?
Belongs to the VPS10-related sortilin family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Protein: NU3M_PODAN
Sequence: MSSMTLFILFVSIIALLFLFINLIFAPHNPYQEKYSIFECGFHSFLGQNRTQFGVKFFIFALVYLLLDLEILLTFPFAVSEYVNNIYGLIILLGFITIITIGFVYELGKSALKIDSRQVITMTRFNYSSTIEYLGKI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: SECA_AGRRK
Sequence: MVSLGGIARKLFGSSNDRRVKSYQPNVVAINALEEQMRALSDEALAAKTVEFRQQLADGKTLDDILVPAFAVAREASRRVLGMRPFDVQLIGGMILHSNAIAEMKTGEGKTLVGTLPVYLNALAGKGVHVVTVNDYLAQRDSATMGRLYGFLGMRTGVIVHGLSDDERRDAYACDITYATNNELGFDYLRDNMKYDRGQMVQRGHNFAIVDEVDSILVDEARTPLIISGPLDDRSDLYITIDAFIPGLTKDDYEIDEKQRSANFSEDGTEKLETMLREAGLLKGESLYDVENVAIVHHINNALKAHKLFQRDKDYIVRNDEVVIIDEFTGRMMPGRRYSDGQHQALEAKERVQIQPENQTLAQITFQNYFRMYDKLAGMTGTASTEAEEFGNIYGLDVIEVPTNLPIQRIDEDDEVYRTHEEKFKAIIAEILEAHKRDQPVLVGTTSIEKSELLAELMRKQGFTNFQVLNARYHEQEAYIVAQAGVPGAVTIATNMAGRGTDIQLGGNLEMRVERDLHEVEPGPERDAAIARIAEEIQVLKQRSIAAGGLYVIASERHESRRIDNQLRGRSGRQGDPGRSKFYLSLQDDLMRIFGSDRMDGMLQKLGLKEGEAIVHPWINKALERAQKKVEARNFDIRKNVLKYDDVLNDQRKVIFEQRVELMDATDLTETVGDMRHDVIEDLVSKHIPERAYAEQWDADGLKTAVANFFDLDLPIHDWVKEEGIAEDDIRARLTEVAEKAAAEKAERFGPEIMTYVERSIVLQTLDNLWREHIVNLDHLRSVIGFRGYAQRDPLQEYKAEAFELFQALLNNLRQAVTAQLSRVELVQQPAEPQPPAMHGSHIDATTGQDEFAPLAMINETVVSPENRDPQNPTTWGRIGRNEACPCGSGKKYKHCHGAFENNEVV
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: APC1_ARATH
Sequence: MPPGVRQLTVLGKFKPFGLIAEATDGKSPDDSYQYFLFDPELTGERDDADGNDANFSRQREHELFIRDNCNVRKGYALVEANFIGYWYNACWSNLGRGTEAFLCVLQIACLTIYNTSGEVVSVPLMRTVKSIWPLPCGLLLEQAGEVNPPSHVPFSPVSPILGSREMLRQRKEVGNSSPQNFHSPVAHDLISKRDMPCMSSHLILRDPLEEPGPTYVEERGKLTIMKDYDERTIWTSDRLPLMTSYNKGKMQHSVWAAEFIESNLEASASCSSGIVPDAVLSKRVSFRRIWQAKGAKKAASKVFLATDNSVPVICFLILEQKKLLSVGLQTVEINNEILFDVKPDISWSVSAIAAAPVVVTRSQVKIGLLPHLDIIVLSPENDLFLYSGKQCLCRYVLPSWLGESIGSGDGESAKTDSGFRNLKITGLSDAVLGSINLSVNHSQIFRCALTGKPSSSLANDCIAAIAEGLRSDLYSLFLSLLWGDGHSDLQGSSIHFEWEALCNIFLEICQKPTVVHRKQPKTASESSWEFLLISKFHKTYSRFHNGITSINRLDLEGIVPFDSKICSEETLGSSCELMVQSLDCLHAVYESLKMDNLRKQDLHHLAVLLCNIAKFLDEKCYLDYYIRDFPRLSTTIGACTTLSSSRKPPNLFRWLENCLRRGCLSTNFDDLPDLIRRDGCSIVSWARKVVSFYSVLFGDKPEGRTLSSGVPCNIAPGSYSCNEELTILAMAGERFGLHQLDLLPSGVSLPLRHALDSCRESPPADWPAIAYVLLGREDMALSVFRNFSSSKEFEMQSNTSLISMSIPYMLHLHPVIVPSSESIGLENTKIEDTNSVDGSVIDGMEHIFNSYTQLRYGRDLRLNEVRRLLCSARPVVVQTAANPTISDQEQQQAFTVPKLVLAGRLPSQQNAIVNLDPNIRNIQELKTWPEFHNAVAAGLRLAPLQGKVSRTWIRYNKPGEPNAVHAGLLFGLGLQGYLHVLNLSDIYQYFTQDHESTTVGLMLGLAASYRGTMQPDIAKALFFHVPARYQASYTEFEIPTLLQSAALVSVGMLFEGSAHQQTMQLLLGEIGRRSAGDNVLEREGYAVSAGFSLGLVALGRGGDALGSMDSLVNRLLLYLGAKEERSILVPSLEDHRSAAQITDGSTSNVDITAPGAIIALTLMYLKTESEVIFSKLSIPQTHYDLECVRPDFIMLRVIARNLIMWSRICPTCDWIQSQVPEVVKNGISQLRDDMDNMYEVDVEALVQAYVNIVAGACISLGLRFAGTRDGNARDLLNSYALYLLNEIKPLSATPGNAFPRGISKFVDRGTLEMCLYLIIISLSVVMAGSGDLQVFRLLRFLRSRNSADGHANYGTQMAVSLATGFLFLGGGMRTFSTNNGSLAMLLITLYPRLPSGPNDNRCHLQAFRHLYVLATEARWLQTIDVDSGLPVYAPLEVTVKETKLYSETKFCEITPCILPERAILKRICVCGPRYWPQQIELVFGLRTLGESNLIANSHRELDSDSVDHLVSTFSSDPSLIAFAQLCCDKSWNNSFDFLILDLILWSQVALAYNEAVSTGRLASSGGFVQSIFLASLRKRCEEVLNCSTELKINLRNYLTSEAWPYDKNSKLQKDIIILSWYLKWFNVPSPSIIKAAVEKIKSKSKNSTSAIPLLRLLLPNTHISVIGEIDRVFFPSN
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins.  The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation.  Involved in the control of endoreduplication (By similarity).
What are the official names of this protein?
Anaphase-promoting complex subunit 1, Cyclosome subunit 1, Protein EMBRYO DEFECTIVE 2771.
What is the protein family that this protein belongs to?
Belongs to the APC1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NTPPA_HAHCH
Sequence: MFDGNPGRRRLVLASGSPRRREMIAGLGCEFSIASADIDESVRPSEAAADYVERLAKEKATAVFEARGDQQDIVVLGADTTVVAGGDILGKPVDFDDAKAMLRRLSGTWHEVLTSVALVAAEGCKVTTTLSRVRFRELSEQEIQRYWDSGEPADKAGAYGIQGLAGSFVERVEGSYSSIVGLPLCETVVLLKEFGIKIWSD
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_ACIAD
Sequence: MASKKAGGSTKNGRDSNPKMLGVKIYGGQSVTAGNIIVRQRGTEFHAGANVGMGRDHTLFATADGVVKFEVKGQFGRRYVTVESV
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: CH60_RUTMC
Sequence: MSAKDIKFGSEARNLMLDGVNMLANAVKVTLGPKGRNVVLDKSFGGPTITKDGVSVAQEITLEGKFENMGAQMVKEVASKTNDIAGDGTTTATVLAQALVIEGVKSVAAGMNPMDLKRGIDKATETAVNALREFSQPCNDTKAIAQVGTISANSDISVGDIIADAMEKVGQAGVITVEEGSGFENELDVVEGMQFDRGYLSPYFVNNQESMTANLETPFVLLHDGKISNIRDLLPTLEAVQKSGKALLIIAEDIDGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAILEDIAVLTGGMVISEEVGLSLEKVTEEHLGTAKRIEIGKENTVIVDGAGKKVDIDGRIAQIKAQIETTTSDYDKEKLLERLAKLSGGVAVIKVGAATEVEMKEKKGRVDDALHATRAAVEEGVVPGGGVALVRVIKALDGLTGDNHDQNIGIDIAKRAMEAPLRQIVTNGGGEASVILNEVAKGKDNYGYNAATEKYGDMLKMGILDPTKVVRAALQHAASISGLMITTEAMITDTPQDTPATAAAPDMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIE_STUS1
Sequence: MKESSRLRGLYAITDSKLLADGRLLPYVEAALKGGARLLQYRDKTSDEARRLREADALQELCARHGAQLIINDDAELAARLGVGLHLGQEDGSLAAARALLGRQAIIGATCHAQLPLAEQAARDGASYVAFGRFFQSHTKPGAPAANHELLREARARIGLPIVAIGGITLDTAPSLIAEGVQMIAVIHALFAADSAAEVERRAQAFSQLFNTP
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: CRCB_ELUMP
Sequence: MTLLKEFFIVGAGGFVGSVMRYLMAVVLASASLKHGFPYATLAVNVLGSFMIGFLSQPFSANPYGRLFVMVGVLGGFTTFSTFSNETLLLYNNGQFIFASLNVLLNVLLCLVGVFCGFEAAKIIL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL9_KOCRD
Sequence: MAKIILTQEVSGLGSAGDVVDVKNGYARNFLFPRGFATPWSRGAEKQIESIKQARAARELSSLEDAQALAAKLTSTTLTVPVTAGAEGRLFGTVRAGDIASAVENAGLGSIDKRRVDLTQRIKTTGVYQAVVHLHEDVNANVEFEVVPA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: PDXA_SACD2
Sequence: MSHPAIIALTPGEPAGIGPDLTVMAAQQARDYPLVALCDPQLLKDRAKLLGLPLTVSTYIQGSAVTTSAQHISVMPIPLGAPCEAGTLDSTNAAYVIETLKQATEGCLSGEFAAVVTGPVQKSVINEAGINFSGHTEYFADNSNTPRVVMMLATEGLRVALATTHLPLKDVSAAITTASLTETLNILLADLQLKFGLSQPRVLVCGLNPHAGEGGHLGMEEIDTIIPVLEQFRARGHNLVGPLPADTLFNPKYLSDADAVLAMYHDQGLPVLKYKGFGNAVNITLGLPFIRTSVDHGTALDLAGTGKANIGSLQVALGYAQNLAMQQASINEIAG
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT_MESVI
Sequence: MADEGEVSALMCDNGSGMVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLAYVAIDYEAELATANTSSSIEKSYELPDGQVITIGNERFRCPEVLFNPGYVGMESAGIHETTYNSIMRCDVDIRKDLYGNIVLSGGSTMXPGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQAMWIAKSEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.