PharMolix/UniProtQA huggingface dataset:
Protein: CLPP2_FRACC
Sequence: MRHEQARQAAAQPQGRYVLPNIIEKTSRGEYGMDPYSKLLKERIVFLGVQIDDVSANDVMAQLLFLESEDPDRDISIYINSPGGSFTSLTAIYDTMQFVRPDISTICMGQAASAAAVLLAAGTPGKRFALENSRILIHQPSAQGEGQSSDIEIQAREILRMRSLLERMLAVHTGKKEEDIRKDIERDKIFSADEAKEYGLIDEVIKTRKSSRLATAR
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_RHOPA
Sequence: MTDDVTNVEQPSTASEQQPQDVPAAEPSAAKKRRANKAKSKATAAAIEQRLGHSFADPSLLTTAFTHVSALKSARRTDSYQRLEFLGDHVLGLIVSDMLYRAFPDADEGELSKRLADLVRKETCADVARSLDLVEGIKLGTVGAGAGAKLRKSVLGDICEAVIGAIYLDGGYEAASDFVRRNWTERMRKPARSLRDPKTVLQEWAQARGLPTPVYREVERTGPHHDPQFRVAVILPGLEPAEGLGGSKRAAEKVAASAMLAREGVGTGGNDG
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOHO_ECO45
Sequence: MRIAKIGVIALFLFMALGGIGGVMLAGYTFILRAG
What are the official names of this protein?
UPF0387 membrane protein YohO.
What is the protein family that this protein belongs to?
Belongs to the UPF0387 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PKHA_EMENI
Sequence: MKPSSNICQATSFIFGGHIGPQTKNSLEKEIREVANGPNGGWILDTLAGMPRYWEAVTEKIPEVASTMQGVQLLSDLESWFRIGSDSVDSLAPDAELPDLWLGILMVIIQLDQYWRYLESRFADRAVDDLQGELIKEEKVEAVGFCAGMIAAVAIASSHTRQEFKKYGAVALRIAALMAILVGATEEWTKAMGKGRSVSFATAWRTRKQGDDMARIISKLSPDAYISVILDDSRATVTVSERLAPKLVRQLRAAGVTAIQLAFKGQLHSPTAERKRLTEAVVELCQSMPELRYPVAARLALPINQVSGQETDLVGMVLRSMLVNQLNWTSTTSMLTLNKEELSRVEFGLDRPLPPPVVRAFGAMLDYKEVDVPKHRQYDKGKEPVHDTESVQVAEPPLQEADENVIAVVGMSIKVAGANDLEEFQQMLKTGHSQHQLVTNDHITPNMMFRNKVPNRKWYGNFVRDPDAFDHKFFKKSPRESMAIDPQGRLSLEAAYQALEQSGYFNELTMTSAAEQERKKHVGVYVGVCSYEYDSNVHCHPPSAFTTTGELRSFIPGRISHYFGWTGPSLTFDTACSSSTVALHNACRDLLSGEVPAALCGGVNILTSLQWTQNLAAGSFISPTGQCKPFDSGADGYCRGDGIAYVFLKKLSNAVADGNTVLGTICSTGVNQNLNTTPLFVPNVPSLSTLFNEVIRKARIARRDISLVECHGTGTPVGDPAEWQSIRNAVAGPRRDTVLPIGSVKGHVGHTEGASGLVSLIKVLMMMRGNFIPPQASFNTMSPGIHAQPSDNMEVVTALRSWPGAQKVALINNYGACGSNSSAIVAHSAHKPVKGPLSGGQRLPFWISGLDARSIAAYSTALASYLHSQDQAASLADAKLALAAKATKDTAPSVGIVPVKPERPVILCFGGQVSTFIGLDRAVYEGASVFRHHLDTCNAAITSHSLESIYPDIFSSEPYQDTIKLQTALFAMQYASAKTWMDCGIAEKVVSVVGHSFGEITALCVSGVLSLEDSVKLIAGRAKLVQTAWGADSGSMMAIEADGAVVQDLLQESNARSDGTAGIACYNGPRSFTVAGSTKAIDAFAATLPGKEVKSKRLNVTNAFHSALVESIVDRLGEVGKEVTFHDAVIPIERATEHSGDATLDWTFVGSHMRRPVFFNHAVQRLAEKYPDAIFLEAGSNSTITVMASRALANPKSTHHFQSISITNTNKGIARLTDATVDLWKQGLRVSFWAHHRFQKDEYAQLLLPPYQFEKTRHWLELKSPIEQAMNIAKVQDGIAAQKGHVNNKSLEIWTFLGFQKQKKKTKLARFRINTSSDKYQRLFATHVIAKTAPIAPATLEIDMAIETLFSLNPEWRQSGFSPVIRDMLSHSPMCADSTREYFLDLVPLNPTETEWQWTIQSTGTSSANDKHAEGRIAMYSSSDPAALQEFGRWERIVTYAQCQAVLALGSQDEGVEALQGRNVYRAFEEVVDFGSVYRGVKYIVGQEKGESAGIVHKQHSGDTWLDVPKADCYGQIAGMYVNLLTDIPSSDMFVATGLELVMRSPKAQTVTDGRENGPNVWHVLARHARQGEKAYVTDVFVFDASTGALAEVILGLQYVRVPKATMSKILARMTTDKSFVRSTATASLLLPDRPQPHDGPITATVPRPAPPKATKTNVAKTEPVSSARNIAKEVCNVVANVSGIEASELSLDSEMADLGIDSLMAMEVAREMENTFHCTLDSTETMVATNIRDFAACVSNALARSGGQDGASTSTESDAMLSDSEDEDTDSGISTPDDASEITSKSHDPVSEPLTSTILNVDHGDVAARNAEALRLVEAYTAGWDSRAVKDANNRIITTGSGDGAVVIVTGASGSLGSHLVQALAERPDVSGVVCINRPVKDTPPDSRQEEALSSRSIKLSPAAREKLQVYGTDTSKAQLGLSKKEYNWLAQHGTHIIHNAWPMSATRPLKAFEPQLQVMRNMLDLARDMALGDEPRRIGFQFVSSIGVTGLSNESPVLEQPVAFAATIPGGYNEAKWTCERMLTDTLRRHPQLFQAMVARPGQISGSTASGFWNPVEHFPFVVKSAHALKVFPDLQGVLHWLPVDKAASIMVDLLSISGSKGSGEVYPVYHVDNPVGQLWKEMVTVLAASLDIPPHGIVPFREWIQRVRQSSLPPAQNPASMGLGFLESHFERMACGGIVLDTQHSREHSETMAAQGPVSAEVVRSYVSSWKAMGLLRH
What is the function of this protein?
Highly reducing polyketide synthase; part of the pkh gene cluster that mediates the biosynthesis of 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde (PubMed:22510154).  The highly reducing polyketide synthase pkhB first produces the (2E,4E,6E)-octa-2,4,6-trienyl strater unit for the non-reducing polyketide synthase pkhA (PubMed:22510154).  This octatrienoyl starter is then loaded onto the SAT domain of the NR-PKS pkhA to be condensed with 4 malonyl-CoA units to yield 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde (PubMed:22510154).
What are the official names of this protein?
Non-reducing polyketide synthase pkhA, NR-PKS pkhA, Pkh biosynthesis cluster protein B.
Protein: SPIKE_CVHOC
Sequence: MFLILLISLPTAFAVIGDLKCTSDNINDKDTGPPPISTDTVDVTNGLGTYYVLDRVYLNTTLFLNGYYPTSGSTYRNMALKGSVLLSRLWFKPPFLSDFINGIFAKVKNTKVIKDRVMYSEFPAITIGSTFVNTSYSVVVQPRTINSTQDGDNKLQGLLEVSVCQYNMCEYPQTICHPNLGNHRKELWHLDTGVVSCLYKRNFTYDVNADYLYFHFYQEGGTFYAYFTDTGVVTKFLFNVYLGMALSHYYVMPLTCNSKLTLEYWVTPLTSRQYLLAFNQDGIIFNAEDCMSDFMSEIKCKTQSIAPPTGVYELNGYTVQPIADVYRRKPNLPNCNIEAWLNDKSVPSPLNWERKTFSNCNFNMSSLMSFIQADSFTCNNIDAAKIYGMCFSSITIDKFAIPNGRKVDLQLGNLGYLQSFNYRIDTTATSCQLYYNLPAANVSVSRFNPSTWNKRFGFIEDSVFKPRPAGVLTNHDVVYAQHCFKAPKNFCPCKLNGSCVGSGPGKNNGIGTCPAGTNYLTCDNLCTPDPITFTGTYKCPQTKSLVGIGEHCSGLAVKSDYCGGNSCTCRPQAFLGWSADSCLQGDKCNIFANFILHDVNSGLTCSTDLQKANTDIILGVCVNYDLYGILGQGIFVEVNATYYNSWQNLLYDSNGNLYGFRDYIINRTFMIRSCYSGRVSAAFHANSSEPALLFRNIKCNYVFNNSLTRQLQPINYFDSYLGCVVNAYNSTAISVQTCDLTVGSGYCVDYSKNRRSRGAITTGYRFTNFEPFTVNSVNDSLEPVGGLYEIQIPSEFTIGNMVEFIQTSSPKVTIDCAAFVCGDYAACKSQLVEYGSFCDNINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINFSPVLGCLGSECSKASSRSAIEDLLFDKVKLSDVGFVEAYNNCTGGAEIRDLICVQSYKGIKVLPPLLSENQISGYTLAATSASLFPPWTAAAGVPFYLNVQYRINGLGVTMDVLSQNQKLIANAFNNALYAIQEGFDATNSALVKIQAVVNANAEALNNLLQQLSNRFGAISASLQEILSRLDALEAEAQIDRLINGRLTALNAYVSQQLSDSTLVKFSAAQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGLYFIHFSYVPTKYVTARVSPGLCIAGDRGIAPKSGYFVNVNNTWMYTGSGYYYPEPITENNVVVMSTCAVNYTKAPYVMLNTSIPNLPDFKEELDQWFKNQTSVAPDLSLDYINVTFLDLQVEMNRLQEAIKVLNQSYINLKDIGTYEYYVKWPWYVWLLICLAGVAMLVLLFFICCCTGCGTSCFKKCGGCCDDYTGYQELVIKTSHDD
What is the function of this protein?
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell- cell fusion.
Protein: OPSD_RANTE
Sequence: MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWKYSILAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTITLYTSLHGYFVFGQSGCYFEGFFATLGGEIALWSLVALAIERYIVVCKPMSNFRFGENHAMMGVAFTWIMALACAVPPLFGWSRYIPEGMQCSCGVDYYTLKPEINNESFVIYMFVVHFLIPLIIITFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWVPYAYVAFYIFCNQGSEFGPIFMTVPAFFAKSSAIYNPVIYIMLNKQFRNCMITTLCCGKNPFGDDDASSAATSKTEATSVSTSQVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  Required for photoreceptor cell viability after birth (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: DYDC2_HUMAN
Sequence: METNYLKRCFGNCLAQALAEVAKVRPSDPIEYLAHWLYHYRKTAKAKEENREKKIHLQEEYDSSLKEMEMTEMLKQEEYQIQQNCEKCHKELTSETVSTKKTIFMQEDTNPLEKEALKQEFLPGTSSLIPGMPQQVPPSESAGQIDQNFKMPQEINYKEAFQHEVAHEMPPGSKSPF
What are the official names of this protein?
DPY30 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the dpy-30 family.
Protein: YODI_BACSU
Sequence: MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVGGGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW
What are the official names of this protein?
Uncharacterized protein YodI.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ATPD_BRUSU
Sequence: MAETSSLISGVAQRYAGSLFELALDANSVASVEKDLGRFEALLSGSKDLRRLISSPVFSSEDQLHAIGAIADKAGIKGLVGNFLRVVAQNRRLFALPGIIAAFRQIAAEHRGEISADVVSAHELTSAQQNELKATLKGVAGKDVTINVTVDPSILGGLIVKMGSRQIDTSLRTKLSSLKLALKEVG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL14_BACCN
Sequence: MIQQESRLKVADNSGARELLTIKVLGGSGRKYANIGDIIVATVKQATPGGVVKKGDVVKAVVVRTKSGARRPDGSYIRFDENAAVIIKDDKSPRGTRIFGPVARELRDSNFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: BODG_CAEEL
Sequence: MLSALLIRNIRNASKLASVAGPNSDRIVNVKWSDGKTGVFPLIWLRDTSPDPSTYTISPAMTARKLTMLEFDVEQNARKLWIDEDANCLKIEWESGVLSEFPSEWLKIRNPSDQEARRRRRKVYLFPEQTWGKAEIEGKLKKFSHEEFMKNEQVVHDFLQAVCIDGIAVLKGAPQGVRGAVEAIGDRIGMIKRTHFGLVFEVSLKADASNMAYASNGGLPFHTDFPSLSHPPQLQMLHMLQSAEEGGHSLFVDGFHVAEQLRVEKPEIFKILTTQSMEYIEEGYDVHEINGKTIRFDYDMCARHKVIRLNDDGKVNKIQFGNAMRSWFYDCEPSKVQDVYRAMKTFTEYCYQPRNMLKFRLEDGDTVLWANQRLLHTRDGFRNAPEKARTLTGCYFDWDIVKSRVRFLRDKLSLEQNQPSA
What is the function of this protein?
Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
What are the official names of this protein?
Probable gamma-butyrobetaine dioxygenase, Gamma-butyrobetaine hydroxylase, Gamma-BBH, Gamma-butyrobetaine,2-oxoglutarate dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-BBH/TMLD family.
Protein: TEX35_HUMAN
Sequence: MSAKRAELKKTHLSKNYKAVCLELKPEPTKTFDYKAVKQEGRFTKAGVTQDLKNELREVREELKEKMEEIKQIKDLMDKDFDKLHEFVEIMKEMQKDMDEKMDILINTQKNYKLPLRRAPKEQQELRLMGKTHREPQLRPKKMDGASGVNGAPCALHKKTMAPQKTKQGSLDPLHHCGTCCEKCLLCALKNNYNRGNIPSEASGLYKGGEEPVTTQPSVGHAVPAPKSQTEGR
What are the official names of this protein?
Testis-expressed protein 35.
Protein: LOLD_PECAS
Sequence: MSDLSLLQCTNLSKRYQDGKLSTDVLRDVSFEMSSGEMMAIVGSSGSGKSTLLHVLGGLDTPTSGEVIFKGQPLSTLSAAAKADLRNRELGFIYQFHHLLPDFTALENVAMPLLIGKVPTSQAQDKAREMLAAVGLEARSHHRSSELSGGERQRVAIARALVNSPSLVLADEPTGNLDQRTADTIFELLGELNVRQGTAFLVVTHDLQLAGRLNRQLEMRDGQLQQELTLMGARQ
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TIC_ARATH
Sequence: MDRNREARRVPMAAAGNGLSRRRHRAGSFRDSPEEEGPVELPEAARLRDRGGSNKKDRDRERDRDRERERERDRERDRLNSRSKRRRGERLMMVHGNLDDGGDDSSEESVNDDEEYDDGGVGPPSSLKMLPPTSNNISAASFSSSLSNHHNGGSGNLHHHHHSHNNNHQRKNNFPPTKVFRSSPSPAPVSPLVSTWKAADEMIGVSVPRKARSACTKRPHESWASSTTGGGVFASGEQIHRQISSTSPANRVSPASILASPSPPAPTSPSSSSISVRKKLPSGTKQKPLPPKSSSSKLSSPVAVQDEIEIEIAEVLYGMMRMPSTSKQEAAGNDLTEAAKSTVEVKSRVSSPISNPQTLPQSSITLAANSSSSNVSAIAPKRKKPRHVKYEDDNSSRVTTIKSEAEAPSKSQVPFSNQLKSSGSGEGNSSVLDSIIPLTRESNASLDSEKKENNLSKDETILPKVESSSGFRSDGEGAKSSSPEKEKFEIDLMAPPPVRSSSERGGEMMECVAAEAKPKVTEVETEAKPLLKEDRSDPAIHDSQEKKRPRMVAEAEHHKFERNCELKLDLDKSDHVGLVNKHHVQKPPPQQQLSVPDKTAQASHLPLHMSMPGWPGGLPTMGYMAPTQGVVPTDTSSLSAAAMQPPPHLLFNQPRPKRCATHCYIARNIQSHQQFTKMNPFWPAAAGSAPMYGTKACNLSLMPPTELQGSVLGRSSNPVQDKNSQSTSKSSETAQRNQLMLQQALPPGAANSILHGPTFIFPLGQQPHAAATIAAASVRPPNSGITSSGPTATSTSMNGSASATPAGAPTMSFSYPAMPGNETQYLAILQNNGYPFPVPAHVGAQPAYRGAPGQPMPFFNGSFYSSQMIQPPHHQPQKQHQQQLTGQMLQSHAPNNQNGSASTGSSAAQKHLQNQQLRPPINHGNSQGFPTHKVQSQPLNFQQRQQPRENATQHSETVGEDSPSTADSRGSRSNVAYGQNYGMQMQPTNLGLMSSPAPGGGVVGSSSSHGEKKSQQQVSKAGVESFQSPGYAMTFATFNGANTAPTLNMSSIAQNHAMFHSMPEAARQGYQMMAAQAAQQKMNYGASLEDGKSGSIGGAATANNTPEEQRKSGGGAIGKTSGGNGGQSIAFSNKQDLADASVSAVTSGSIVDSSSRLLNLGSALPQSSGSLPTSHHQQLLQQQQQQHMQRSQSQQPYTTMYLQKQQRYATSVAASAARTKGPVVSNGSGFPDHNMTTSPAGTTKFANANSGFPQNLVQSSSNQVQSQQWKNNSPRTTNTTQAQSPSMLSPSTSVAAASSLRNIPHKQQSRPQQSQISFAANSKPMTSGSPMQQVQGGTNHQAPSPPMLVGSPSTSSVSKNASGSPRTTASASSAANKGGQASTTTHSASQPSKNLQPASAASSAGGRNNGPSVLGNPTTSSGSKSQQQQQLPKHGLQPQAQLFFSNPYMQAQHQHQQQQITISPSGGYYIQRHQQQSGSAPAVPVTGAVTATSDPAKAIAAASAANNMKGGGGMGKTQQHQLGPPGFTNVHAVSSAVQVKPVDQKQQAGE
What is the function of this protein?
Regulator of normal clock function.  Acts in the mid to late night.  Contributes to the amplitude of circadian clocks.  May act on the transcriptional induction of LATE ELONGATED HYPOCOTYL (LHY).  Inhibits MYC2 protein accumulation, acting as a negative factor in the JA-signaling pathway.
What are the official names of this protein?
Protein TIME FOR COFFEE.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSSA_DAUCA
Sequence: MASGARELSTMEADIQMMCAAEVHLGTKNCDFQMERYVFKRRNDGIYIINLGKTWEKLMLAARVIVSIENPQDIIVQSARPYGQRAVLKFAQYTGAHAIAGRHTPGTFTNQLQTSFSEPRLLILTDPRTDHQPIKEAALGNIPTIAFCDTDSPMRYVDIGIPANNKGKHSIGCLFWLLARMVLQMRGVISQGHKWEVMVDLFFYREPEETKDQEEEDLPVGDYVADYAAAPIGGADQWNAIPDAQWGGDVVQPANSAVPAGTWTDAGPIAGDGWDAAAAPPVPGAVGLDVPAPTGWE
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein SA, p40.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_RHOJR
Sequence: MTLRLFDTETRALRDFVPLAPGHASVYLCGATVQGDPHIGHVRSGVAFDVLRRWLLAHDYDVAFVRNVTDIEDKILNKAAEAGRPWWEWAATFERSFTWAYQQLGVLPPSVEPRATGHITQMVEMMQRLIDNGHAYAAGGDVYFDVRSYPRYGSLSGHKLDDVHQGESAGECKRDPRDFTLWKAEKPGEPSWPTPWGRGRPGWHLECSAMAEFYLGAAFDIHCGGLDLVFPHHENEIAQAKCAGDDFAQYWLHNGWVTMGGEKMSKSLGNVLSVPNVLKKVRPQELRYYLGSAHYRSMLEYSDTALDEGAAAFRRIESFVLRTQERAGEVPVGLWTEAFARALDDDLAVPAALAEVHGKVREGNIALDGGDLEGARGIASQVRAMLGILGVDPLDEHWTQETADASAATDALDVLVRAELERRQSARAEKNWAVADEVRDRLIRAGIEVTDTPNGPEWSLKAGQ
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR4_XANAC
Sequence: MMVLEGASALSPFRRARLETRLQTLVPALRITGAWHVYFIRPEAGQSPDQATLQRILQANAAPAERDADASSRYVVPRLGTLSPWSSKATELVRGAGQPIQRVERGTRIDLAGWPDDASAQAAVAKLLHDPMTQSLLGSAAAAEALFNVPDPGQLRRVPLDGLEQANRDLGLALAQDEIDYLRERFGALGRDPADVELMMFAQANSEHCRHKIFNATWTIDGKPQERSLFRMIKHTHQQTPQHTLSAYSDNAAVVEGVPAARYRPDPATGQYRSEAVLPSAFAIKVETHNHPTAIAPFPGAATGAGGEIRDEGATGRGGKPKAGLTGFSVSHLRIPTLPQPWEAPRALNPRMAPALDIMLDGPLGGAAFNNEFGRPNLLGYFRSFELAEGPGLTRAYDKPIMLAGGLGAIDRNQVEKLRLQPGDAVIVLGGPAMLIGLGGGAASSVAAGDSAEALDFASVQRENPEMERRCQEVIDRCVALGVDNPIRWFHDVGAGGLSNAIPELLHDSGVGGIIDLGRVLTDDPSLSPLELWCNESQERYVLGVPQARLEEFAAICARERCPFAAVGVATAEERLVVGYGVLDAGNRESGVGNRNGTLVAADTASHHSPFPTRDSQLPIDLPMDVLFGKAPKMHRDAAHPGAPQWPVLQTASLDLQQAGLRVLAHPTVASKSFLVTIGDRSVGGLTAREQMIGPWQLPLADCAITLAGFDTFEGEAMSIGERTPLALLNAAASARMAVGEAITNLCAAPVQTLDSIKLSANWMAAAGHSGEDALLYDAVRAIGMELCPALELSVPVGKDSLSMQAQWQVGNRESGIGNGETPQPSASTIPDSPFPIPGETLKSVSPVSLIISAFAPVGDVRTQLTPLLRSGEESELWLIGLGGGKQRLGGSVLAQVYADDTALPAFGGEVPDLDDAQRLRSFFELIRDARDSGLLLAYHDRSDGGAFAALCEMAFASRQGLDITLDAWGDDAFRSLFNEELGAVVQIASEDRAAFADLVERHALTECAQRIARPTGTPRIRVSGQGRVLAEWRWEELFDAWWSVTHAMQKLRDNPDSADEERALARDFKASGLRPKLVFDPSDDVAAPFVATGTRPKVAILREQGVNGQIEMAYNFERAGFRPYDVHMSDLIEGRVDLSAFVGFAACGGFSYGDVLGAGRGWATSILERSALRDAFAAFFARSDTFALGVCNGCQMLSQLKDIIPGAEHWPRFLRNRSEQFEARTALLEVVESPSIFLRGMAGSRIPVAVAHGEGRAEFDSAVDQAAARVALRYIDGDGAVASQYPLNPNGSPDGITGLTSSDGRVTILMPHPERTPRSANLSWYPVDWGDDSPWLRMFRNARVWCG
What is the function of this protein?
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_CAMJD
Sequence: MNIHEYQAKAIFADNGILTLKGKVAFSVDEAVSNAKELGGSVWAVKAQIHAGGRGLGGGVKIAKNLDEVKDYASKILGMNLVTHQTGPEGKLVQKLYIESGANIVKEYYLAILFNRMAEQITIIASSEGGMDIEKVAKESPGKIAKVGIDPQIGFKMFHGLEVARVLGLDKDEGKKLISMIAKLYKLYMDKDMNMLEINPLIKTAEGDFYALDAKCSFDDSALYRHPEIAELRDITEENPAEREAAEFGLSYVKLDGDVACMVNGAGLAMATMDIINYSGAKPANFLDVGGGASPETVAKAFEIILRDKNVKVIFINIFGGIVRCDRIANGILEATKNVEVNIPIVVRLDGTNAAEAKTILDNSNLKNIKAATNLKNGAELVKSLVG
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: NL1B1_MOUSE
Sequence: MEESPPKQKSNTKVAQHEGQQDLNTTRHMNVELKHRPKLERHLKLGMIPVVYMKQGEEILYPAQSLREENLIQNFTSLLLLQKLCPKDPENMIRKSWASCVPEEGGHMINIQDLFGPNIGTQKEPQLVIIEGAAGIGKSTLARLVKRAWKEGQLYRDHFQHVFFFSCRELAQCKKLSLAELIAQGQEVPTAPINQILSHPEKLLFILDGIDEPAWVLADQNPELCLHWSQRQPVHTLLGSLLGKSILPEAFFLLTTRTTALQKFIPSLPMPCQVEVLGFSGIERENYFYKYFANQRHAITAFMMVESNPVLLTLCEVPWVCWLVCTCLKKQMEQGRVLSLKSQTTTALCLKYLSLTIPDKHRRTQVKALCSLAAEGIWKRRTLFSESDLCKQGLDEDAVATFLKTGVLQKQASSLSYSFAHLCLQEFFAAISCILEDSEERHGNMEMDRIVETLVERYGRQNLFEAPTVRFLFGLLGKEGVKGMEKLFSCSLHGKTNLKLLWHILVKSQPHQPPCLGLLHCLYENQDMELLTHVMHDLQGTIVPGPNDTAHTVLQTNVKHLVVQTDMELMVATFCIQFYCHVRTLQLNMEKQQGYALISPRMVLYRWTPITNASWEILFYNLKFTRNLEGLDLSGNSLRYSVVQSLCNTLRYPGCQLKTLWLVKCGLTSRYCSLLASVLSAHSSLTELYLQLNDLGDDGVRMLCEGLRNPVCNLSILWLDLSSLSAQVITELRTLEEKNPKLYIRSIWMPHMMVPTENMDEEAILTTLKQQRQESGDKPMEILGTEEDFWGPTGPVATELVDRVRNLYRMPQMMVPTENMDEEDILTSFKQQRQQSGANPMEILGTEEDFWGPIGPVATEVVYRERNLYRVQLPMAGSYHCPSTRLHFVVTRAVTIEIEFCAWSQFLDKTPLQQSHMVVGPLFDIKAEQGAVTAVYLPHFVSLKDTKASTFDFKVAHFQEHGMVLETPDRVKPGYTVLKNPSFSPMGVVLRIIPAARHFIPITSITLIYYRVNQEEVTLHLYLVPNDCTIQKAIDDEEMKFQFVRINKPPPVDNLFIGSRYIVSGSENLEITPKELELCYRSSKEFQLFSEIYVGNMGSEIKLQIKNKKHMKLIWEALLKPGDLRPALPRIAQALKDAPSLLHFMDQHREQLVARVTSVDPLLDKLHGLVLNEESYEAVRAENTNQDKMRKLFNLSRSWSRACKDLFYQALKETHPHLVMDLLEKSGGVSLGS
What is the function of this protein?
Constitutes the active part of the Nlrp1b inflammasome (PubMed:30872533, PubMed:30872531).  In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of Nlrp1b (NACHT, LRR and PYD domains-containing protein 1b, N-terminus), preventing activation of the Nlrp1b inflammasome (PubMed:30872533, PubMed:30872531).  In response to pathogen-associated signals, the N-terminal part of Nlrp1b is degraded by the proteasome, releasing this form, which polymerizes to form the Nlrp1b inflammasome complex: the Nlrp1b inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis (PubMed:31268597, PubMed:30872533, PubMed:30872531).
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 1b allele 1.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Membrane. SUBCELLULAR LOCATION: [NACHT, LRR and PYD domains-containing protein 1b, C-terminus]: Inflammasome.
Protein: TVB78_HUMAN
Sequence: MGTRLLCWVVLGFLGTDHTGAGVSQSPRYKVAKRGQDVALRCDPISGHVSLFWYQQALGQGPEFLTYFQNEAQLDKSGLPSDRFFAERPEGSVSTLKIQRTQQEDSAVYLCASSL
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 7-8.
What are the subcellular locations of this protein?
Cell membrane.
Protein: YCIB_HAEIE
Sequence: MKQLLDFIPLILFFITYKLGGVREAAIVLVVATILQIVILKWKYGTVEKQQKIMASAVVFFGLLTAYFNEIRYLQWKVTIINGLFAIVLLIAQFQFKTPLIKKLLGKELQLPEKAWNTLNFGWAIFFIICMLVNIYISHNMSEEAWVDFKSFGIIGMTVIATIISGVYIYRYLPKDGSNSKDGEK
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.