PharMolix/UniProtQA huggingface dataset:
Protein: SHSA2_XENLA
Sequence: MWLEGSPLAVLAAVSFLLSVLAAAQGSGEYCHGWLDAQAVWRDGFQCPERFDGDDSTICCGKCELRYCCSSAEARLDQGVCNNDRQQGAPDHNRPDKDSPDSTAVPIYVPFLIVGSVFVAFIIVGSLVAICCCRCLRPKQEPQQSRAPGSNRLMETIPMISSASTSRGSSSRQSSTAASSSSSANSGARPPPTRSQTNCCLPEGAMNNVYVNMPTNFSVLNCQQATQLVQHQGQYLHPQFVGYAVPHDSVPMTPVPQFIDGLQGGYRQMQSPYPHSNPEQMMYPAVTV
What is the function of this protein?
Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both fgf and wnt signaling.  Inhibits both wnt and fgf signaling through the regulation of protein maturation and cell surface transportation of their receptors within the endoplasmic reticulum.
What are the official names of this protein?
Protein shisa-2, Transmembrane protein 46.
What is the protein family that this protein belongs to?
Belongs to the shisa family.
Protein: MENH_CROS8
Sequence: MPLTAYFQPARAAARGTVVWLHGFLGDHREWQTVAAACVEHNHLFIDLPGHGGSAHLCAVDFAHVNEQLIATLNSYNILEYWLVGYSLGGRIAMFHATQGNTPGLRGLVVEGGHPGLLNADERDARFVADKQWAQRFHDEPIETVLDAWYRQPVFATLTDAQRQELITLRACNAPTALATMLEATSPGRQPPLYEPLARLSVPFHYLCGERDAKFRALAATLNVPLHLITGAGHNAHRENPAAVACCLNAILRP
What is the function of this protein?
Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
What are the official names of this protein?
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, SHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MenH family.
Protein: UNG_SUHVK
Sequence: MEGPPPSKRPCGLPPGVRLVVPAAAAASASNAATAAAAAAPAGAGAGASKPARPSAAARPAKGTPAASAATTATGADASAPPPDPGAPTWDAFAAEFDVAPSWRALLEPEIAKPYARLLLAEYRGRCLTEEVLPAREDVFAWTRLTAPEDVKVVIIGQDPYHGPGQAHGLAFSVRRGVPIPPSLANIFAAVRATYPTLPAPAHGCLEAWARRGVLLLNTTLTVRRGVPGSHAPLGWARLVRAVVQRLCETRPKLVFMLWGAHAQKACAPDPRRHKVLTFSHPSPLARTPFRTCPHFGEANAYLVQTGRAPVDWSVD
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines.  Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG, UNG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: YCF55_PORPU
Sequence: MNNYWPNSQGPILNKEVAELLVRTSVKINKKLTNCSNEVLILDVFRTEVKRNLLKIILAELEKILLEIYTSNLDLSDVTNLTESILIDLFHRSIKRFCRLYELDYNSICQNVHDINYLMYDYKMLLQILIIQLIFGSSSKVKKTFNLFAENIPIKQVEIFLENYLIQLSNIIAHILIQNFETVQETNASYLCNVKFLSDRKLEKLKNNLVWNTLIQNYIERPRAIYESRYKVWVFYQDGLNCQYVYACRSTELYTLSSAQVLVTFLLEIQDFFIPKIKSTVFLIGQFIIYIGQNIFNQIMRTFLEIIRRSSNFKKQSSSL
What are the official names of this protein?
Uncharacterized protein ycf55, ORF320.
What is the protein family that this protein belongs to?
Belongs to the ycf55 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MOAB_ECO57
Sequence: MSQVSTEFIPTRIAILTVSNRRGEEDDTSGHYLRDSAQEAGHHVVDKAIVKENRYAIRAQVSAWIASDDVQVVLITGGTGLTEGDQAPEALLPLFDREVEGFGEVFRMLSFEEIGTSTLQSRAVAGVANKTLIFAMPGSTKACRTAWENIIAPQLDARTRPCNFHPHLKK
What is the function of this protein?
May be involved in the biosynthesis of molybdopterin.  Can bind GTP and has low GTPase activity.  Can bind MPT, but has no MPT adenylyl transferase activity.
What are the official names of this protein?
Molybdenum cofactor biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the MoaB/Mog family.
Protein: 6PGL_ERWT9
Sequence: MKQVVYTASPESQQIHAWQLNNEGALTLLQVVDAPGQVQPMVVSPDKSFLYVGVRPDFRVVAYQIDAEGKLKEAGHAPLPGSPTHISTDRQGRFIFVGSYNDACVSVTPIGENGLPGEPLQVVKGLEGCHSANIDLNNQTLFVPALKQDRIALFSLDKQGKLTPRAQAEVKTRSGAGPRHMAFHPNQRYAYSVNELDSSVDVWDISGDEVKKVQSVDALPEGFSDTRWAADIHITPDGRHLYSCDRTASNITIFSISAEGSSLKVEGYQPTETQPRGFNIDHSGQYLVAAGQKSHHIEVYKISADRGLLQPLARYAVGQGPMWVVINKLD
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6-P-gluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: RL30_RALSO
Sequence: MSQKIVKVQLVRSLIGTREDHRATVRGLGLRRLNSVSELQDTPAVRGMINKVSYLVKVIG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: ILVD_RUEST
Sequence: MPMYRSRTSTHGRNMAGARGLWRATGMTESDFGKPIIAIVNSFTQFVPGHVHLKDLGQMVAREVESAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREVIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKIDIDSLDAKKIDLVDAMVAAASDKLTDEEVQHIEENACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHSDRKQLFLEAGRKIVEITKRHYEQNEKGLLPREIATFEAFENAMSLDIAMGGSTNTVLHLLAIAHEGKVDFTMQDIDRLSRKVPCLCKVAPNIENVHMEDVHRAGGIFSILGELSRAGLLHNDVPTVHSDSMGEAIAHWDIAVADNQAAKDLFKAAPGGVRTTQAFSQSNRFKDLDIDRKGGVIRSKEHAFSQDGGLAVLFGNIALDGCIVKTAGVDASILKFTGKAYVCESQDQAVNDILTGKVQAGDVVVIRYEGPRGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHVSPEAAEGGTIGLVEHGDTIEIDIPNRSIHLAVDEATLAARRAAQDEKGWKPVAKRKRKVSTALKAYALLATSAAKGAVRQLPDDE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: NUOD_COXB1
Sequence: MAEVRNYTFNFGPQHPAAHGVLRLIVEVDGEVIQRIDPHIGLLHRATEKLAESKPYNQTIGYMDRLDYVSMMANEHGYVLAIEKLLGIEPPIRAKYIRTMFDEITRILNHLLWLGAHALDVGAMTVFLYCFREREDLMDCYEAVSGARMHATYYRPGGVYRDLPDSMPKYKPSRWHNEKAVKKMNEAREGSLLDFIWDFTARFPNLIDEYESLLTDNRIWKQRTVGIGVVSAERALQLGFTGPMLRASGVEWDLRKKQPYAAYDRVDFDIPIGREGDCYDRYLVRIEEMRQSNRIIRQCVEWLRKNPGPVMIDDYKIVPPQREVMKRDMEALIHHFKLFTEGYIVPEGEAYAAVEQPKGEFGVYIVSDGANKPYRVKVRAASYPHLAAMNEMCRGHMIADLVAIISSIDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATPA_CLOPE
Sequence: MHIKPEEITSIIKNEIKNYEKELETVDSGTIIQIGDGVARVYGLEECMEGELLEFPNQVFGMALNLEQDNVGCVLLGSEEGIKEGDIVKRTGKIVEVPVGEDLIGRVVNSLGQPIDGKGPIKNDGYRAIEVPAPGILERSSVNEPLQTGIKAIDSMIPIGRGQRELIIGDRQTGKTAIAIDTIINQKGKDVICIYVAIGQKQSTVANIVNTLTEEGAMDYSIVVTASASESAPLQYIAPYSGCTMGEYFMNKGKHVLIIYDDLSKHAVAYRTMSLLIRRPPGREAYPGDVFYIHSRLLERAAKLSKENGGGSLTALPIIETLAGDVTAYIPTNVISITDGQIFLETELFNAGQRPAVNPGISVSRVGGNAQIKAMKQVSGTLRLELAQYRELASFAQFGSDLDKDTQARLEKGKRLIEILKQDQYKPMAVEKQIMIIYAAVNNFLLDIKVSDIKRFEKEFLEYMDTHHREIGKAILDKKVLDDELKSALESAIVEFKKIFLM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HIS7_DESOH
Sequence: MKRSASVQRQTAETQVSVTVLLDGIGTQTISTGIPFFNHMLSLFAAHGFFDLTVQASGDIDVDFHHTVEDVGIVLGNSVNKALGDRKGIRRYGYAVTPMDEALAHAVIDLSNRPFLVFNVPSIPAAETGFGVQLAKEFFRAFAVNCGMTLHIRVDYGENEHHVIESVFKAVARALDMATSMDDRITGPLSTKGCI
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SV2A_BOVIN
Sequence: MEEGFRDRAAFIRGAKDIAKEVKKHATKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPADGYYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLGDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGAWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ
What is the function of this protein?
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission.  Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
What are the official names of this protein?
Synaptic vesicle glycoprotein 2A, p87.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Presynapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals.
Protein: RIBA_ECOL6
Sequence: MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIIERVPLIVGRNPNNEHYLDTKAEKMGHLLNK
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: MSCL_ECO5E
Sequence: MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPTKEEVLLTEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ILVD_METMP
Sequence: MISDNVKKGVIRTPNRALLKACGYTDEDMEKPFIGIVNSFTEVVPGHIHLRTLSEAAKHGVYANGGTPFEFNTIGICDGIAMGHEGMKYSLPSREIIADAVESMARAHGFDGLVLIPTCDKIVPGMIMGALRLNIPFIVVTGGPMLPGEFQGKKYELISLFEGVGEYQVGKITEEELKCIEDCACSGAGSCAGLYTANSMACLTEALGLSLPMCATTHAVDAQKVRLAKKSGSKIVDMVKEDLKPTDILTKEAFENAILVDLALGGSTNTTLHIPAIANEIENKFITLDDFDRLSDEVPHIASIKPGGEHYMIDLHNAGGIPAVLNVLKEKIRDTKTVDGRSILEIAESVKYINYDVIRKVEAPVHETAGLRVLKGNLAPNGCVVKIGAVHPKMYKHDGPAKVYNSEDEAISAILGGKIVEGDVIVIRYEGPSGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHVSPEAAAGGVIAAIENGDIIKIDMIEKEINVDLDESVIKERLSKLGEFEPKIKKGYLSRYSKLVSSADEGAVLK
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: SPEA_SALSV
Sequence: MSSQEASKMLRTYNIAWWGNNYYDVNELGHISVCPDPDVPEARVDLAKLVKAREAQGQRLPALFCFPQILQHRLRSINAAFKRARESYGYNGDYFLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKDREYIRLALIGEKMGHKVYLVIEKMSEIAIVLEEAERLNVVPRLGVRARLASQGSGKWQSSGGEKSKFGLAATQVLQLVETLRDAGRLDSLQLLHFHLGSQMANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNIIWAIGDACEEHGLPHPTVITESGRAVTAHHTVLVSNIIGVERNEYTDPTAPAEDAPRALQNLWETWQEMHKPGTRRSLREWLHDSQMDLHDIHIGYSSGAFSLQERAWAEQLYLSMCHEVQKQLDPQNRAHRPIIDELQERMADKMYVNFSLFQSMPDAWGIDQLFPVLPLEGLDQVPERRAVLLDITCDSDGAIDHYIDGDGIATTMPMPEYDPENPPMLGFFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVEVELSDEGDTVADMLQYVQLDPKTLLTHFRDQVKQTDLDDALQQQFLEEFEAGLYGYTYLEDE
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: RNPH_SYNP6
Sequence: MAWIRPDGRRPDQLRAIAFQRRFTQFPAGSVLAQFGQTQVLCTVTIQAGVPRWLTGQGQGWLTAEYRMLPGATPDRQSREWLKLSGRTQEIQRLIGRSLRAAIDLKKLGERTLLIDADVLQADAGTRTTAINGSWVALQDAIAQLIAQGELTESPIQRSIAAVSVALIGGEAFLDPDYPEDVQADVDCNVVMGDRGELIEIQGTAEANPFSRTQLNHILDLAEQGIAQIQAAQLEALR
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RL11_VIBCH
Sequence: MAKKVEAYVKLQVAAGMANPSPPVGPALGQRGVNIMEFCKAFNARTESLEKGLPIPVVITVYSDRSFTFETKTPPASVLLKKAAGIKSGSARPNTAKVGTITDAQIQEIAATKAADMTGADIEAMKRSIAGTARSMGLVVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: VAPC1_AQUAE
Sequence: MNSEKVFVDGNVIVDIFDERRVNHKYSVQAIRILLANKFDLLTSSDLITTVYYVLSKIDKKKALSDIKEVVNILEIIPFGKAEVEKAIELMEGDKNFKDLEDTLQYVLAKKEGCKLILSNDKSFYSPDIEVLTTEEFCERWNTL
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.
What are the official names of this protein?
Ribonuclease VapC1, RNase VapC1, Toxin VapC1.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: RL33_PASMU
Sequence: MAAKGPREKIKLVSTAETGHFYTTTKNKRNMPEKMEIKKYDPVVRKHVVYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: CMR1_CANAL
Sequence: MALSELEKKRQENIRRNQELLKKLDLDSISDSIKKEVDNKSFSSPSSQKRRKTTKKPVIKKEISEPSRRSRRIAGIKSELEDPKQAARIREEEELKQHRKQELERLKRTRLFGDFKLIDLITNKKGDMIFEKNVMDRKLSHIGLDSKVEEKKNEEDKEDEEEAINIDENNRVLQLVQSLGDKFSAGDFYEEIRNSQTNGNSKDKSLDAKRKEFDNLNIYPRFDPLDIKICHNRITSMFFHPSTTNRIVVGGDTTGNVGIWLVDEQNNDTKEEEEDDDDDEPSISILQLHGRNVSKIMTPTFSPEKIYTSSYDGSIRVLDLNKLTSTELLYLNEPGAREDIALGVSDINQCQDSSVIFMTTLDGEFYQHDTRTPFNTRQRHHLATKDLLRLHDKKIGGFAVNPNTNYQIATASLDRTLRIWDLRNVNKSVYSEFENQKSPHMYGNYNSRLSVSCVDWNQENRLVCNGYDDNICLFDYSGGSKLDNELPVITEWKSDFVPSTKSSEESELLPNNLTPFTKIKHNCQTGRWVSILKSHWQTNPADGVQKFIIANMNRGLDIYNQDGQILAHLNEQVGAVPAVCTLHPSQNWAVGGSASGKVYLFE
What is the function of this protein?
DNA-binding protein that binds to both single- and double-stranded DNA.  Binds preferentially to UV-damaged DNA.  May be involved in DNA-metabolic processes.
What are the official names of this protein?
DNA damage-binding protein CMR1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat DDB2/WDR76 family.
Protein: TRHO_STRPD
Sequence: MSEKIRVLLYYKYVSIENAQEYAAKHLEFCKSIGLKGRILIADEGINGTVSGDYETTQKYMDWVHSDERFADLWFKIDEENQQAFRKMFVRYKKEIVHLGLEDNNFDSDINPLETTGEYLNPKQFKEALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKDKFMEKRVVVYCTGGVRCEKFSGWMVREGFKDVGQLHGGIATYGKDPEVQGELWDGAMYVFDDRISVPINHVNPTVISKDYFDGTPCERYVNCTNPFCNKQIFASEENETKYVRGCSPECRAHERNRYVQENGLSRQEWAERLEAIGESLPEFVGA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: SYR_WOLSU
Sequence: MHHTIKHLLETTLGFSVVLEKPKDKNHGHYATPAAFSLAKELKKNPALIAQELSKKLSEIEVFESVQSVGGYINFRLKQGFLDAQASLALSQGREFGKGDKQGSILLEYVSANPTGPLHIGHARGAVLGDALSRIGRHLGYALETEYYVNDAGNQIHLLGLSIYLAGRDSLLSLPVTYPEQYYRGEYIVDIAKEALKKWGEKAFADEAFIPELSLFGKELMLEEIRSNLADTHIHFDHYVSEKSLYPRWEETYALLQSHQGCYEGGGKVWLRSSAHGDEKDRVIVRESGEPTYLAGDIIYHADKFARPYDRYINIWGADHHGYIARVKAAIEFLGHDSSKLEVLLSQMVTLLKGGQPYKMSKRAGNFILMRDVLEDIGADALRFIFLSKKPDTHLEFDVDDLNKEDSSNPIFYINYAHARIHTMLGKSSLDSQEIEAASLEGLEDSIFDLLFLSLQLPQVLEDSFENRAIQKVAEYLRALAGEFHKFYNEHKILETPQEAALLKVCKVVALSLSQGLALLGITAKERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_LACH4
Sequence: MPLVPKRVKHRREFRGKMRGAAKGGKYIAFGEYGLEALESHWITNRQIEAARVAMTRYMKRGGKVWIRIFPQKSYTAKGVGVRMGSGKGAPAGWVAVVKREKIMFEIGGVDEATAREALRLASTKLPIKTKFVTRSSEVGGESNEG
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: MYOM1_APLCA
Sequence: MQVYMLLPLAVFASLTYQGACEETAAAQTSSDASTSSASSEHAENELSRAKRGSYRMMRLGRGLHMLRLGKRGGPVEPESEENLETLLNLLQGYYSDVPEYPSEFDDTDLAYPYEEYDAPAHPRYRRSTPPTDGVVAPDVLQKGSSEFEDFGDSQLDESDEGYYGYDPENYLYGDFEDYLEPEEGGLGEEKRSLSMLRLGKRGLSMLRLGKREGEEGDEMDKKQDESLNDDFENDDIKRTLSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRDDDEKEKKSLNMSRLGKRSTQ
What is the function of this protein?
Exogenous application of myomodulins potentiates ARC muscle contraction.
What are the official names of this protein?
Myomodulin neuropeptides 1.
What are the subcellular locations of this protein?
Secreted.
Protein: TRUB_XYLFA
Sequence: MLMSRIAYCRLDGILLLDKPAGISSNSALQIARRLLRAKKGGHTGSLDPLATGLLPLCFGEATKIAGLLLGSTKAYDADVLLGTTTTTDDAEGAVLLTRPVPTLDAEMVDAVIPQLIGRIRQRAPIYSALKQGGEPLYAKARRGEVVNAPVREVEVHAIELLVLATPRLQLRVTCGSGTYIRSLVRDLGEILGCGAHITALRRRWVAPFQIPKMLTLDALEQALSAGRDPDSLLLPLVEGLAGFPALELDAQRLACFRLGQRLRDHSFQTGRVAVFSRDGIPAGLGEVDSEGLLVPQRLFNL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: MSCL_ECOLC
Sequence: MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPTKEEVLLTEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL2_ACIBT
Sequence: MPIQKCKPTSPGRRFVEKVVHDHLHKGAPYAPLVEAKKRTGGRNNNGHITTRHVGGGHKQHYRIVDFKRNKDGVPAVVERIEYDPNRTAHIALLKYADGERRYIIAPKGLRAGDKVQSGNDAPIRPGNCLPLRNMPIGSTLHNVELKIGKGAQLARSAGASVQLLGRDGSYAIIRLRSGEMRKVHVECRAVIGEVSNQENNLRSLGKAGAARWRGVRPTVRGMAMNPIDHPHGGGEGRNKGIQPVSPWGQKAKGYKTRTNKRTTKMIIRDRRVK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: MDPK_EMENI
Sequence: MPLATYAVLGATGNTGTALIQNLLSPPSSEMHINAYCRNKPKLLNLLPELNDTKNVTIFEGSITDLSLITACIRNTRAVFLTVTSNDNIPGCRLSQDSVQTVLEALKQIRTAEPNAVVPKLVLLSSATIDPHLSRKMPSWFLPIMKTAASNVYADLIKAEEMLRANESWVTSIFIKPAGLSVDIQRGHKLDFDEQESFISYLDLAAAMLEAANDTDGRYDGRNVSVVNTGGKARFPPGTPKCIIVGLLRHFFPGLHRFLPTTGPS
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative (PubMed:20139316, PubMed:21351751, PubMed:22730213).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG (PubMed:20139316).  The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG (PubMed:20139316).  The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone (PubMed:20139316).  The next step is performed by the anthrone oxygenase mdpH that catalyzes the oxidation of emodinanthrone to emodin (By similarity).  Emodin is further modified to yield monodictyphenone via several steps involving mdpB, mdpC mdpJ, mdpK and mdpL (PubMed:20139316, PubMed:21351751).  These enzymes with xptA, xptB and xptC are also proposed to be involved in the synthesis of shamixanthone from emodin (PubMed:22730213).  Especially, direct reduction of emodin by the short chain dehydrogenase mdpC followed by dehydration catalyzed by the scytalone dehydratase-like protein mdpB gives loss of oxygen and formation of chrysophanol intermediate in two simple steps (PubMed:22730213).
What are the official names of this protein?
Oxidoreductase mdpK, Monodictyphenone synthesis protein k.
What is the protein family that this protein belongs to?
Belongs to the avfA family.