PharMolix/UniProtQA huggingface dataset:
Protein: VP4_ROTRA
Sequence: MASLIYRQLLSNSYVTNISDEVSEIGARKTTNVTVNSGPFAQTGYAPVNWGHGELSDSTLVQPTLDGPYQPTTFNLPINYWMLIAPTQAGRVAEGTNTTNRWFACVLVEPSVQSTRREYVLDGQTVQLQVSNDSSTLWKFILFIKLEKNGTYSQYSTLSTSNKLCAWMKREGRVYWYTGTTPNASESYYLTINNDNSHVSCDAEFYLLPRSQTDLCDQYINNGLPPVQNTRNVVPVSITSREIRYTKAQMNEDIVVSKTSLWKEMQYNRDIIIRFKFANSIVKSGGLGYKLSEISFKPMNYQYTYTRDGEEINSHTTCSVNGVNDFSYNGGTLPTDFSISRFEVIKENSKVYIDYWDDSQAFRNMVYVRSLSANLNDAVCSGGDYTFALPVGAWPVMSGGAVTLSSEGVTLSTQFTDYLSLNSLRFRFRLTVSEPSFSISRTRLSGIYGLPAANPNNNVEYYEIAGRFSLISLVLTNDDYQTPIANSVTVRQDLERQLGELREEFNALSQEIALSQLIDLATLPLDMFSMFSGIKSTVETVKSMTTNIMKKFKTSNLANAISDLTNSMSDAASSVSRSVSVRSIGGNATSRISTAIQAGDDLRTVADASTQISSVSRSLRLREFTTQADNLSFDDISAAVLKTKLDKSTQISQSTIPDIISESSEKFIPMRTYRVIDNDTAFETGIDGHFYAYRVDTFDEVPFDVERFNKLITDSPVLSAIIDFKTLKNLNDNYGITKTQAMELLQSNPKTLKEFINNNNPIIRNRIENLIAQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: RL9_NITMU
Sequence: MQIILMEKVVNLGQLGDVVKVKNGYARNFLIPQGKAKRATQAAVAEFESKRAELEKTQADILAAAQARAAKLEGLMLQVTQKAGVDGKLFGSVTNADIEDALKAQGFEVERSMIRMPQGSLKQVGDHPVTIVLHTDVAAHIIVSVLGESVS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: HIS2_SULIK
Sequence: MSNEIVDKLYKVILDRIEKRPTGSYTAEIVNKGKAYVARKVGEESVETIVASLAENKERFISEVADLIYHLLVLMALEGVTPDDIYRELERRRK
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1796_NOSS1
Sequence: MSHLNIANLGEDFVAQWLQSTGWIILHRQFSCRWGEIDIIAQHTRNNQESILAFVEVKTRSPGNWDDGGRGAITLKKQAKIERTAKIFLAKYPDKAEYICRFDVAIVAYQGISQQDHAAIGEYKFQLQEYIPAAFDCLIY
What are the official names of this protein?
UPF0102 protein alr1796.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: PRD14_MOUSE
Sequence: MALPPSGETQSQDKANYLPQSNPHHLTTYYAHAPGYSHFRNLATTEEEFQPWKLAAAVLESQAMAPLDAFRMTAPLLNPGLAVQSEPLYNLPWYKLSPWNRIPQFTPEVPRFLDSTEHRSSGSSNQNLVLGGGGGQISGQRWEAENLLLPSPVIASLLPDGIKSSQSISVPQTLNQEGKLPFCGFNFTEEELSFVLYGAIASPEHPTDLQHAISGILVPTESSGSNHLHKTLDKDSLQLPEGLCLMQTSFGDVPHFGVFCSDFIAKGVRFGPFRGRVVNASEVKAHRDNSRMWEIFEDGHLSHFIDGKGSGNWMSYVNCARFPKEQNLLAVQHQGQIFYESCRDIQRNQELLVWYGNGYEKFLGVPMNLRVTEQGGQQLSESSEESAEGYRCERCGKVFTYKYYRDKHLKYTPCVDKGDRKFPCSLCQRSFEKRDRLRIHILHVHERHRPYLCSTCGKSFSQSSSLNKHMRVHSGDRPYQCVYCTKKFTASSILRTHIRQHSGEKPFKCKHCGKAFASHAAHDSHVRRSHKDNGRSSCDICGKGFLDQEAFYAHMRLHKTC
What is the function of this protein?
Transcription factor that has both positive and negative roles on transcription (By similarity).  Plays a role in cellular pluripotency.  Essential for germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression.  Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation.
What are the official names of this protein?
PR domain zinc finger protein 14, PR domain-containing protein 14.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARGC_STAES
Sequence: MHISIVGITGYTGLELLRLALNHPHVTVSSIHATKEVGVQISDIFPHLKGIFDKEIQVFDSEFIMTHSDLVFFATPSGVAKDLSKNFVKNNFPVIDLSGDHRLSPDVYLKWYKKSPCTVDIQKRFTYGLSEVMNISHRNRFIANPGCYATATELALYPLISNHLIRVDSIIVDAKSGLTGAGKKLNQSSHYVNVNNNYVTYKLNKHQHIPEIVQTLQFFNKSLQNIQFSTSLIPVNRGIVATIYTRLENGVKINQIESTYKDVYKNKPFIRIKDGLPQLNEVIGTNYTDIGFVYNETTGVLTISSVIDNLIKGAAGQAIQNMNLMFNFDETDGLILAPLYI
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_SALSV
Sequence: MRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSLTLESSLRTFTFDNGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLNGYQHYDTAAAVTCALLRGLSREPLRTGRILNVNVPDLPLAQVKGIRVTRCGSRHPADKVIPQEDPRGNTLYWIGPPGDKYDAGPDTDFAAVDEGYVSVTPLHVDLTAHSAHDVVSDWLDSVGVGTQW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPP_RHOJR
Sequence: MTSFVLASASPARLAVLRSAGVEPIVRVSGVDEDAVIAALGADAAPEHVVTELARAKASDVLPVLARDGISDAVVVGCDSMLLIDGSLQGKPGTVDVARARWSAMAGRSATLLTGHSVLRIAEGAVVGDAHDHSATVVHFASPPDADLEAYLATGEPLQVAGAFTLDSLGGWFVDRIEGDPSSVIGIGLPLVRRLLAEVGVGVAELWASSGRVD
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMA1_MACFA
Sequence: MLLLPLPLLLFFLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKSCGGFLIRRNFVLTAVHCAGRSITVTLGAHNITEKEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRYFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRLDAKPPAVFTRISHYRPWINKILQAN
What is the function of this protein?
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
What are the official names of this protein?
Chymase, Alpha-chymase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Granzyme subfamily.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule. Note=Mast cell granules.
Protein: RBFA_VIBCH
Sequence: MPKEFSRTQRVAQQLQKELAMILQREVRDSRLGMVTISDVEVSRDLAYAKVFVTFLCIGEQTPESCLAALREHEVQIRMMLGKQIRLRLTPEIRFYYDNTLVEGMRMSNLVTEVINSDKRRKHEAGRDEDEA
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSK_ECO57
Sequence: MSKIFEDNSLTIGHTPLVRLNRIGNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASNPEKYLLLQQFSNPANPEIHEKTTGPEIWEDTDGQVDVFIAGVGTGGTLTGVSRYIKGTKGKTDLISVAVEPTDSPVIAQALAGEEIKPGPHKIQGIGAGFIPANLDLKLVDKVIGITNEEAISTARRLMEEEGILAGISSGAAVAAALKLQEDESFTNKNIVVILPSSGERYLSTALFADLFTEKELQQ
What are the official names of this protein?
Cysteine synthase A, CSase A, O-acetylserine (thiol)-lyase A, OAS-TL A, O-acetylserine sulfhydrylase A, Sulfate starvation-induced protein 5, SSI5.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: PCDAA_MOUSE
Sequence: MSCVAMKYCHESWCLLLSLLLFAIWEPGSGQLRYSVPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVRDINDNPPVFPTTEKNLFVSESRALDPHFSLEGASDADIGTNALLTYRLSPSEYFSLEVPTTDELVKPLQLVLKKPLDRERASELHLVVKATDGGKPELTGTLELHITVLDANDNAPAFDRAIYRVKLVENARNGTVVIRLNASDLDEGSNGQILYSFAADVSPKTEATFHIDSVSGEIKVNGKIDFEETNLWKIQAEAVDKGSPPMFGHCTILIEVLDINDNAPKIIVTSLSLPVQEDAPVGTVIALISVMDPDSTVNGQVTCSLSPHVPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDGGSPALWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGVHVFTVLAMDADAQENALVSYSLVERRVGERLLSSYVSVHAESGKVFALQPLDHEELELLQFQVTAKDAGVPALGSNVTLQVFVLDENDNAPTLLPHGAVGAGGAVSELVPRSVGSGHVVAKVRAVDADSGYNAWLSYELQFRAGSVRSPFRVGLYTGEISITRALDEADAPRQRLLVLVKDHGEPALTATATVLVSLVESNQAPKASSRVLGPAASESSVVDVNVYLIIAICAVSSLLVLTLVLYTALRCSALPTEVTCGPGKPMLVCSSAVGSWSYSQQRRQRVCSGEGPPKTDLMAFSPSVPPGLGSGDSGVQQEIFENPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin alpha-10, PCDH-alpha-10.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PROA_ACTP7
Sequence: MQMITLAQQAKIASVELAQFGNVQKNQALLTIAQQLEQRSAEILAANAKDIEFAKNQGISTAIIDRLLLNESRLQGIANDVRNVAKLADPVGQVIDGGVLNSGLKIERQRVPLGVILTIYEARPNVTIDVASLCLKTGNAVILRGGKETKFTNAVLVEVVQQALETAGLPKLAVQAVTDPDRVLLLELLKLDRYIDMVIPRGGAGLHQFCKENSTIPVIVGGIGVCHMFVEKSADQQKALELIANAKTQRPSTCNTLETLLVEKAIAGEFLPKLANRMKALDVTLHTDDLQKTEGIEPLDDARMRQEWLSLDLNVVVIDNLTKAVEHIREYGSQHSEAILTSDYQLARQFVAQVDAAAVYINASTRFTDGGEFGLGAEVAVSTQKLHARGPMGLEALTTYKWVCEGDYLVRK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAG_PEA
Sequence: ELNPSLVISLSTGLSLFLGRFVFFNFQRENVAKQGLPEQ
What is the function of this protein?
Not yet known.
What are the official names of this protein?
Photosystem I reaction center subunit V, PSI-G, Photosystem I 9 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsaG/PsaK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: KDPA_SALTI
Sequence: MAAQGFLLIASFLLILLVLAKPLGSGLARLIAAVPLPGVAGVERILWRTLGITDHEMNWRQYLLALLTLNLLGLGILFCLLFWQEWLPLNPQRLPGLSWDLALNTAVSFVTNTNWQAYSGESTLSYFSQMAGLTVQNFLSAATGIAVVFALIRAFTRQNVHTLGNAWQDLVRITLWILFPVALIIALFFIQQGVPQNLSAYQPITTLEGAKQLLPMGPVASQEAIKMLGTNGGGFFNANSSHPFENPTALTNLAQMLAIFLIPAALCFAFGEAAGDRRQGRALLWAMSFIFVVCVAVVMWAEVQGNPHLLAAGADSSVNMEGKEARFGVLASSLFAVVTTAASCGAVNAMHDSFTALGGMVPMWLMQIGEVVFGGVGSGLYGMLLFVLLAVFIAGLMIGRTPEYLGKKIDVREMKMTALAILVTPMLVLLGSALAMMTDAGRSAMLNPGPHGFSEVLYAVSSAANNNGSAFAGLSANSPFWNCLLAFCMFVGRFGVIIPVMAIAGSLVSKKVQPASQGTLATHGALFIGLLIGTVLLVGALTFIPALALGPVAEHFSLP
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YPC1_YEAST
Sequence: MGIFRWNYPESSVPGVWGETTSTIDWCEENYVVSPYIAEWSNTLTNSVFILSAIYTTYSAYKNKLEKRFLLIGFGYGLVGVGSWLFHMTLKYRFQLLDELPMIYAMCIPTWSLVCEAKEALLNGDNHKKVPLFEQIFIGVIIGLAVTTASILYVIYKNVDIHQILFGVQIVVVAATAGSLTYRYVHDPLAKRNLKASMALGAILFLSGYISWLLDIHYCSFWVHVRRSILALPLGVLLEPHGWWHILTGMGIYFYIVSLEHLRVITLNVSCNYQFIWRWKVFPELIWKGRKPSTRYSLELFGPYVEDQSIEVKKEK
What is the function of this protein?
Alkaline ceramidase that hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine.  Prefers phytoceramide.  Has also reverse activity as acyl-CoA-independent ceramide synthase, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine.  Is not responsible for the breakdown of unsaturated ceramide (PubMed:10702247, PubMed:10900202, PubMed:11694577, PubMed:24866405).  Preferentially uses very long chain fatty acids (C-24 and C-26) in vivo compared to C-16 in vitro (PubMed:24866405).
What are the official names of this protein?
Alkaline ceramidase YPC1, Acyl-CoA-independent ceramide synthase.
What is the protein family that this protein belongs to?
Belongs to the alkaline ceramidase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to the cortical ER.
Protein: ABDH_ECOSE
Sequence: MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINVLFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVSKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal.  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: HUTI_BACFN
Sequence: MSENLIIFNAKVVTPLGFSARKGKEMAELRILEKATVEVVDGIITYVGPNRGEVRDGYYHHFWHYNARGKCLLPGFVDSHTHFVFGGERAEEFSWRLKGESYMSIMQRGGGIASTVQATRELSFIHLRSKAEGLLKKMTAMGITTVEGKSGYGLNRETELLQLKVMRSLNKDEGVRVDIVPTFLGAHALPDEYKERPDDYIDFLIRELLPVIQRDSLAEFCDVFCEEGVFSIEQSRRLLTAAGDYGLLPKLHADEIVPLGGAELAAELGAVSADHLLHASDAGIEAMARKGVVATLLPLTAFALKEPYARGRDMIDAGCAVALATDLNPGSCFSGSIPLTFALACIHMQLTVEEAITALTLNGAAALNRADSIGSIEVGKKGDFVVLDSDNYHILPYYVGMNCVNTTIKGGMLYPSV
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODP2_PSEAE
Sequence: MSELIRVPDIGNGEGEVIELLVKPGDKVEADQSLLTLESDKASMEIPSPKAGVVKSIKAKVGDTLKEGDEILELEVEGGEQPAEAKAEAAPAQPEAPKAEAPAPAPSESKPAAPAAASVQDIKVPDIGSAGKANVIEVMVKAGDTVEADQSLITLESDKASMEIPSPASGVVESVSIKVGDEVGTGDLILKLKVEGAAPAAEEQPAAAPAQAAAPAAEQKPAAAAPAPAKADTPAPVGAPSRDGAKVHAGPAVRMLAREFGVELSEVKASGPKGRILKEDVQVFVKEQLQRAKSGGAGATGGAGIPPIPEVDFSKFGEVEEVAMTRLMQVGAANLHRSWLNVPHVTQFDQSDITDMEAFRVAQKAAAEKAGVKLTVLPILLKACAHLLKELPDFNSSLAPSGKALIRKKYVHIGFAVDTPDGLLVPVIRDVDRKSLLQLAAEAADLADKARNKKLSADAMQGACFTISSLGHIGGTGFTPIVNAPEVAILGVSKATMQPVWDGKAFQPRLMLPLSLSYDHRVINGAAAARFTKRLGELLADIRTLLL
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: RL5_RUBXD
Sequence: MARLKDRYRQEVAPALKERFGIDNPMRVPTLEKIVVNMGVGEAAQDSRKLDGAMEDLARITGQKPQVRRARKSIAGFKIREGMPVGARVTLRGERMWEFLDRLISVALPRVRDFRGVSPDSFDGRGNYALGVREQLIFPEISYDAVDSVRGLDIAIVTTAETDEEARELLRLLGMPFRPN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: MAPK3_BOVIN
Sequence: MDVETAEEQGGPAPPSGVPCGPCSAGAPALGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVRILDVYENMHHSKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSRNIAHRDVKPENLLYTSKDKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPSPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDRDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSGSQGCNNQ
What is the function of this protein?
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation.  Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates.  Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue.  MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2.  Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36.  Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively.  Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs.  Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript.  Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.  Also acts as a modulator of Polycomb-mediated repression (By similarity).
What are the official names of this protein?
MAP kinase-activated protein kinase 3, MAPK-activated protein kinase 3, MAPKAP kinase 3, MAPKAP-K3, MAPKAPK-3, MK-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
Protein: TRUB_STRP8
Sequence: MINGIINLKKEAGMTSHDAVFKLRKLLQEKKIGHGGTLDPDVVGVLPIAVGKATRVIEYMTEAGKVYEGQVTLGYSTTTEDASGEVVARSSLPAVLTEELVDQTMTTFLGKITQTPPMYSAVKVNGRKLYEYARAGESVERPRREVTISLFERTSPLNFTEDGLCRFSFKVACSKGTYVRTLAVDLGRALGVESHMSFLQRSASAGLTLETAYTLGEIADMVSKQEMSFLLPIEYGVADLPKMVIDDTELTEISFGRRLSLPSQEPLLAAFHGEKVIAILEKRDQEYKPKKVLI
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: GLDH1_ORYSJ
Sequence: MRRLLLAGILRRASSSPSSHHHLHLVRALSASSPLPASDADLRKYAGYALLLLGCGAATYYSFPLPPDALHKKAVPFKYAPLPDDLHAVSNWSATHEVHTRVLLQPDSLPALHDALAAAHGECRKLRPLGSGLSPNGLALSRAGMVNLALMDKVLGVDAKKKTVTVQAGIRVAELVDALREHGLTLQNFASIREQQVGGIIQVGAHGTGARLPPIDEQVISMKLVTPAKGTIELSREKDPDLFYLARCGLGGLGVVAEVTLQCVERHQLIEHTFVSNADEVKKNHKKWLSENKHIKYLWIPYTDTVVVVQCNPPSRWRTPKFTSKYGKDEAIQHVRDLYHESLKKYRTKAESNDPEVDQLSFTELRDRLLTLDPLDKDHVIRINKAEAEYWKKSEGYRMGWSDEILGFDCGGQQWVSETCFPAGTLAKPNMKDLDYIEELLQLIEKEDIPAPAPIEQRWTACSRSPMSPASSSQEDDIFSWVGIIMYLPTSDARQRKEITEEFFNYRSKTQTNLWDGYSAYEHWAKIEVPKDKDELAELQARLRKRFPVDAYNKARMELDPNKVLSNAKLEKLFPVTEVQHEK
What is the function of this protein?
Involved in the biosynthesis of ascorbic acid.
What are the official names of this protein?
L-galactono-1,4-lactone dehydrogenase 1, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.