PharMolix/UniProtQA huggingface dataset:
Protein: CP39A_MOUSE
Sequence: MGIMELFSPIAIAVLGSCVLFLFSRLKNLLGPPCIQGWIPWIGAGLEFGKAPLEFIEKARIKYGPVFTIFAMGNRMTFVSEEEGINVLLKSEHVDFESAVQSPVYHTAWIPKNVFSALHERLYALMKGKMGTFNTHHFTGPLTEELHEQLEGLGTHGTMDLNDFVRYLLYPATLNTLFKKGLFLTDKRTIKEFYQQFKTYDEGFEYGSQLPEWLLRNWSKSKRWLLALFEKNIGNIKAHGSAGHSGTLLQAILEVVETETRQYSPNYGLVVLWAALANAPPIAFWTLGYILSHPDIHRTVLESISSVFGTAGKDKIKVSEDDLKKLLIIKWCILESVRLRAPGVITRKVVKPVKILNHTVPSGDLLMLSPFWLHRNPKYFPEPESFKPERWKEANLDKYIFLDYFMAFGGGKFQCPGRWFALLEIQLCIILVLYKYECSLLDPLPKQSSRHLVGVPQPAGKCRIEYKQRA
What is the function of this protein?
A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis.  Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:10748047).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10748047).
What are the official names of this protein?
24-hydroxycholesterol 7-alpha-hydroxylase, Cytochrome P450 39A1, mCYP39A1, Oxysterol 7-alpha-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Protein: RPOB_CHLFF
Sequence: MFKCPERVSVKKKEDILDLPNLIEIQIKSYKQFLQIGKLAEERDNVGLEEVFREIFPIKSYNEATILEYLSYNLGVPKYSPEECIRRGITYSVTLKVRFRLTDETGIKEEEVYMGTIPIMTDKGTFIINGAERVVVSQVHRSPGINFEQEKHSKGNILFSFRIIPYRGSWLEAIFDINDLIYIHIDRKKRRRKILAMTFIRALGYSSDADIIEEFFQIEECSLKSEKDFSVLVGKILADNVLDEASSLVYGKAGEKLSTAMLKRMLDADISTLKIALEADENHPIIKMLAKDPTDSYEAALKDFYRRLRPGEPATLANARSTIMRLFFDPKRYNLGRVGRYKLNRKLGFPMDEESLSQVTLRKEDVIGALKYLIRLKMGDEKASIDDIDHLANRRVRSVGELIQNQCRSGLARMEKIVRERMNLFDFSSDTLIPGKIISAKGLTSVLKDFFGRSQLSQFMDQTNPVAELTHKRRLSALGPGGLNRERAGFEVRDVHASHYGRICPIETPEGPNIGLITSLSSFAKINEFGFIETPYRIVRDGVVTDEIEYMTADVEEECVIAQASANLDEYNMFTDPVCWARYRGEAFEADTSTVTHMDVSPKQLVSIVTGLIPFLEHDDANRALMGSNMQRQAVPLLKTEAPIVGTGLEARAAKDSGAIVVAEEDGVVEYVDGYKVVVAAKHNPTLKRTYEFKKFLRSNSGTCINQRPLCSVGDIVVKGDVIADGPATDQGELALGKNILVAFMPWYGYNFEDAVIISEKLIKQDAYTSIYIEEFELTARDTKLGKEEITRDIPNVSEEVLANLGEDGIIRIGAEVKPGDILVGKITPKSETELAPEERLLRAIFGEKAADVKDASLTVPPGTEGVVMDVKVFSRKDRLSKSDDELVEEAVHLKDLQKGYKNQISVLKTEYREKLGALLLNEKAPASIIHRRTADILVQEGTVFDQETIELLEQESLVDLLMPPCDMYDVLKNLLSDYETSLQRLEVNYKTEVEHIREGDADLDHGVIRQVKVYVASKRKLQVGDKMAGRHGNKGVVSKIVPEADMPYLANGETIQMILNPLGVPSRMNLGQVLETHLGYAAKTAGIHVKTPVFEGFPESRIWDMMIEQGLPADGKSYLYDGKTGERFDNTVVIGYIYMLKLSHLIADKIHARSIGPYSLVTQQPLGGKAQMGGQRFGEMEVWALEAYGVAHMLQEILTVKSDDVSGRTRIYESIVKGENLLKSGTPESFNVLIKEMQGLGLDVRPMVVDA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: GNL3_XENTR
Sequence: MKRPKLKKGSKRLSCHKRYKIQKKVREHNRKARKEAKKSGTRKQKKEISVPNNAPFKAEILQEAQRRRQQEEELKQNRKLERQKEVAKRRKLDEKKKKNSEKREKRDNKKNKGTKAAESAEVVSCRHVNKVLEQSDVVLEVLDARDPLGSRCAQAEEAVLKSPNKRLLLLLNKADLVPRDVLEKWLQVLTAELPTVPFRCLPQAPSKSPGKKHKVPNTADLCTENRCPGGQVLLRILHSLCPSQSDAIKVGVIGFANVGKSSVINSLKQSHVCNVGPTKGTTRVLQEVRLDPQIRMLDSPALVVSPQNAPLAVMLRSVSDCNVDVLAAVSAILKHCSKQELMLHYTLPDYRNSLECVTLLAQRRGLLKKGGVPDTEAAGRLLFNDWMGVRMKYYCQPPDSPGVQPHITKEVTAAMSSGICSEQLAQDNASTLKALKCPSPANLVVFTSVGPTGAIMDERQLVEPEPIEEELEANDGEEDVEEEHEGSEEEEDEEVEQEVVSAKEQEVVSAKEQEVVSAKEQDSKSAGPSVSFDQAQEDDAYDFNTDFV
What is the function of this protein?
May play a role in regulating cellular proliferation.
What are the official names of this protein?
Guanine nucleotide-binding protein-like 3, Nucleostemin-like protein.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus.
Protein: CS2LB_MOUSE
Sequence: MKFIILTCLLAVALAKQRMEQYISSEESMDNSQENFKQNMDVAFFPSQETVENIYIPQMESVEAPMKVSDIISQQQYNQKMMDMSVSAREKTVMTEESKNIQDYMNKMKRYSKITWPQFVKLLHQYQKTMTPWSYYPSTPSQV
What is the function of this protein?
Important role in the capacity of milk to transport calcium phosphate.
What are the official names of this protein?
Alpha-S2-casein-like B, Casein alpha S2-like B, Epsilon-casein.
What is the protein family that this protein belongs to?
Belongs to the alpha-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2516_SHESH
Sequence: MSFWKNKTLAEMDTQEWESLCDGCGKCCLNKLIDDETEELYYTNAACKLLDPKDGHCVHYVQRFNFVPSCTQVTVDNVAELTWLPDSCAYRRLHLGRELPSWHPLITGSKEAMHIAGMSIKNKVTCETKVKYMEDHIVLWPLKDIE
What are the official names of this protein?
UPF0260 protein Ssed_2516.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: CYB6_ORYSI
Sequence: MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTEAFSSVQYIMTEANFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLAVLTASFGVTGYSLPWDQIGYWAVKIVTGVPDAIPVIGSPLVELLRGSASVGQSTLTRFYSLHTFVLPLLTAVFMLMHFLMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SELA_GEODF
Sequence: MNLLKQIPKVDKVLSWEGVQTLLETHPRPVVMKAVRNVLEVLRAIVLREEGDAGLFTDEAIMKRVNRELDEINSLNLKRLVNGTGVVIHTNLGRSPLPESVRQTLNEIAFGYSNLEFDLATGERGSRYSHVEEILCELTGAEAALVVNNNAAAVLLALSSLAAGREVIVSRGELVEIGGSFRIPDVMRQSGAILREVGATNRTHLQDYSAAVATETGLLLKVHCSNFAVVGFTAEVSAEQLVELGRQHSLPVMADVGSGNLVELSRRLGCNEPTVQEFVSAGVDVITFSGDKLLGGPQAGIIVGRRELLATMKKHPLLRAVRIDKLTLAALEGTLQLYRDERRALQEIPTLRMLALSKEELAETAKRLAARLQKVVPPVVTLALVEGFSQVGGGALPLLQLPTTLISVSVGDKSAQEIEKVMRLSPVPVIGRIFKGAFLLDPRTINEEDISALTAALQGIVP
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPG_CLOTE
Sequence: MAVKQFKAESKRLLDLMINSIYTNKEIFLRELISNASDAIDKRYYRSLTDENISFNKKDFYIRIIPNKEERTLTIIDTGIGMSVEELENNLGTIAKSGSLAFKNKMESKEGIDIIGQFGVGFYSAFMIADKIVVKSHSIDSDEAYKWESKGVEGYEIEKCEKDELGTEIILKIKENTDDENYDEFLEEYNIKNLIKKYSNFIKYPIKMNMKKTKLKEGTKDEYEDYFEDETLNSMVPIWKKNKNEVKTEDYERFYIDKHFGYDKPLKSIRSKVEGVVSYTALLFIPSTTPYDFYTRNFEKGLELYSNGVLIMEKCADLLPDYFSFVQGLVDSEDLSLNISRELLQHDRQLKLIAKNIKEKIKSELLSILKNKREDYIKFYNNFGRQLKYGVYSDFGANKEVLQDLIMFYSSTEKKLVTLDEYVSRMKDDQKYIYYAPGENIDKIEKLPQTEIVRDKGYEILYFADEVDEFAIKMLMNYKEKEFKSVYSKDLGFEAEEKEEQKENDENKEVFEFMKDVLNGKVKEVRASKRLKSHPVCLANASDISIEMEKVLSMMPNNENIKADKILEINTNHNMFNTIKSAFKDDKDKLKMLSSLLYNQALLIEGLPIEDPVQFANDVCKLIK
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAX3I_MESEU
Sequence: MKMFFTVLVTLFVCSMIIGICEGREIPVKCKGSKQCLQSCKEAGMTYGKCMNGKCNCTPKG
What is the function of this protein?
Inhibits voltage-gated potassium channel rKv1. 1/KCNA1 at nanomolar ranges (IC(50)=90 +-2 nM, reduction of current by 30% at 50 nM or toxin).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 3.18, Toxin MeKTx13-2.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 03 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARCA_STRPS
Sequence: MSSHPIQVFSEIGKLKKVMLHRPGKELENLLPDYLERLLFDDIPFLEDAQKEHDAFAQALRDEGIEVLYLEQLAAESLTSPEIRDQFIEEYLDEANIRDRQTKVAIRELLHGIKDNQELVEKTMAGIQKVELPEIPDEAKDLTDLVESDYPFAIDPMPNLYFTRDPFATIGNAVSLNHMFADTRNRETLYGKYIFKYHPIYGGKVDLVYNREEDTRIEGGDELVLSKDVLAVGISQRTDAASIEKLLVNIFKKNVGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLHVYSVTYENEKLKIVEEKGDLAELLAQNLGVEKVHLIRCGGGNIVAAAREQWNDGSNTLTIAPGVVVVYDRNTVTNKILEEYGLRLIKIRGSELVRGRGGPRCMSMPFEREEV
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_AMOA5
Sequence: MAVKIRLAKKGRKKLALYDIVVADQRAPRDGRFIEKLGNYNPNTNPSTVVLHEDKVIQWLFNGAQPTNTVKNILSSQGILLKRHLQIGVKKGAITQEEADKRFLVWKESKTQKPGKFKA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: PCYAB_EUGGR
Sequence: MYILVWKKGQQIKTFHTLDEAAQFKAASNIDEAQMFSVTVAPAISASGGSNEATNLRRLMYLSKSTNPEECNPQFLAEMARVATIRNREIGVSGFLMYSSPFFFQVIEGTDEDLDFLFAKISADPRHERCIVLANGPCTGRMYGDWHMKDSHMDSITTHPAMKTILYQIARSFSSMWSYLPKSAGNMLLLGKDPAAQPPEPMSVVVTFIYLVEFGSILSNPNLTEQAAEVLSTFVDVCVKNVEGSGGNIAKFITGICMAYWPINRTEEALTAIQQISEDLAQLRSQQAPGSAVSLMYSQAGVHYGRAMLCNAGSRKSDFTLLGDCINTTSRIATLAKKLKTPLLFSFEVRCLLGDEMREEIEGAGMHQVKGRDKPVVVYQFPGPELDVEMVRQKIEQFTPGRFRCQMPVVEYEALPISQRPPIFDDTPKGNPRPRTPGYGGRQRSDSLVDRLIMIAKLAGPSVSATGDTTLTTLTYISQATRPMSRLDLSAIMRTATRRNAQQSITGTLLHVNGLFVQTLEGPKDAVVNLYLRIRQDPRHTDVTTVHMAPLQERVYPSEWTLTSATEEMLATFPPLQDVLSQLAKSFTSLETYVPSTVVRYLTAGNNPRNLMPVSCGVVMLATDICSFTSLTEKSSLTEVWMICNTFIDACTSAICQEGGEVIKLIGDCVTAYFPGNNADSAVAAAQELFTFCRQLREAFVDVLDVRGCVSCGVGLDYGQVVMAQCGSLGLTEYVVAGAVSARVMEVEAITREVGYAIVVTEPVADRLSPQLRDHGIVPTPQAIEGLPCYGIAGEEFELDVDSIKRGIKALHAARSGEKPLTEPEEAKPDFRVSPGRVRHGDSGRRSNSAQGKRSIQVR
What is the function of this protein?
Acts as a blue light photoreceptor for the step-up photophobic response.  Mediates photoavoidance.
What are the official names of this protein?
Photoactivated adenylate cyclase subunit beta, Photoactivated adenylyl cyclase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Note=Paraflagellar body, flagellum and paraxonemal bodies (PABs).
Protein: NRDR_NATPD
Sequence: MNCPDCGNGRTRVIDTGASSDGASVRRRRECQRCSFRFTTYERPEWKSLQVKKRDGTIESFDQQKLRTGIERAVEKRGVAETTVTALVDDIESELQDREARIVSSSLIGELVSENLRTLDKVAYIRFVSVYKAFSEPQEFLKELDAVLGAELDDFEASNSSQ
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RUTF_ECO7I
Sequence: MNIVDQQTFRDAMSCMGAAVNIITTDGPAGRAGFTASAVCSVTDTPPTLLVCLNRGASVWPVFNENRTLCVNTLSAGQEPLSNLFGGKTPMEHRFAAARWQTGVTGCPQLEEALVSFDCRISQVVSVGTHDILFCAIEAIHRHATPYGLVWFDRSYHALMRPAC
What is the function of this protein?
Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.
What are the official names of this protein?
FMN reductase (NADH) RutF, FMN reductase, NADH-flavin reductase RutF, NADH:flavin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
Protein: CCME_YERP3
Sequence: MNPRRKSRLYLAMVVLIGISLTTTLVLYALRSNIDLFYTPGEILQGKGERHEKPAIGQRLRIGGMVMPGSVQRDAKTLEMSFQVYDARGAVTVTYTGILPDLFREGQGVVAQGVFAEGNTVHAKEVLAKHDEKYTPPEVEEAMKENHSRPAAAYRGTNTTGNAL
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: GST1A_ANOGA
Sequence: MDFYYLPGSAPCRAVQMTAAAVGVELNLKLTDLMKGEHMKPEFLKLNPQHCIPTLVDEDGFVLWESRAIQIYLVEKYCAHDPALAERLYPGDPRRRAVVHQRLFFDVAILYQRFAEYYYPQIFGKKVAGDPDRLRSMEQALEFLNTFLEGERFVAGGDDPTIADFSILACILDCNVRRCRVRSAAI
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase 1, isoform A, AgGst1-alpha, Aggst1-3, GST class-theta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
Protein: FLT3L_MOUSE
Sequence: MTVLAPAWSPNSSLLLLLLLLSPCLRGTPDCYFSHSPISSNFKVKFRELTDHLLKDYPVTVAVNLQDEKHCKALWSLFLAQRWIEQLKTVAGSKMQTLLEDVNTEIHFVTSCTFQPLPECLRFVQTNISHLLKDTCTQLLALKPCIGKACQNFSRCLEVQCQPDSSTLLPPRSPIALEATELPEPRPRQLLLLLLLLLPLTLVLLAAAWGLRWQRARRRGELHPGVPLPSHP
What is the function of this protein?
Stimulates the proliferation of early hematopoietic cells by activating FLT3.  Synergizes well with a number of other colony stimulating factors and interleukins.
What are the official names of this protein?
Fms-related tyrosine kinase 3 ligand, Flt3 ligand, Flt3L, SL cytokine.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Secreted. Note=Biologically active. SUBCELLULAR LOCATION: [Isoform 4]: Secreted. Note=Inactive.
Protein: CCCA_ARTBC
Sequence: MLGGRHSHWSPQDLEEQAFSPYGTFPPSPTESTETSSSISSTRPRVNPRIVSDAILGLSDGLTVPFALSAGLSALGNSRVVVVGGLAELVAGAISMGLGGYVGSRSEVESYEATVRETKHLVKASPMETMNIIHQVFAPYNLPEEPVARMSHILYNSPEKLLDFLLTFYHKESKPGCHQAWISAITLALGYFIGGFIPLIPYFMVDQVLVALYYSIGIMIFTLLVFGYVKTCVVRGWTGKENIVAGIKGGLQMVVVGGLAAGASIALARAINPTGGALF
What is the function of this protein?
Vacuolar iron transporter involved in the transfer of iron from the cytosol to the vacuole for intracellular iron storage (PubMed:26960149).  Plays an essential role in iron detoxification during high iron conditions (PubMed:26960149).
What are the official names of this protein?
Vacuolar iron transporter cccA.
What is the protein family that this protein belongs to?
Belongs to the CCC1 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: RS3_LACLA
Sequence: MGQKVHPIGMRVGVIRDWDAKWYAEKEYSDYLHEDLAIRQLIQTKLADASVSLIETERAINKVIVTLHTAKPGMVIGKSGANVDALRAELNKLTGKQVHINIVEIKKPDLDAHLVGEGIAKQLEARIAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGADIARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPTKKSVKGEK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RL4_BURM9
Sequence: MELKLLNSNGQEGAVVNASDVVFGRDYNEALIHQVVVAYQANARQGNRAQKDREQVKHTTKKPWRQKGTGRARAGMSSSPLWRGGGRIFPNSPDENFSHKVNKKMHRAGLCSIFSQLAREGRLSVVEDIVLEAPKTKLLADKFKAMGLDSVLVITDTVDENLYLASRNLPHVAVVEPRYADPLSLIYFKKVLVTKAAVAQIEELLS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: AHBC_METBF
Sequence: MIGISKLYCGTVEPSDALRYGRDSKKLPSHLLQFSKDKKPVVVWNMTRRCNLKCVHCYAQAKDIEFENELSTEEGKALIDDLASFGSPVILFSGGEPTMRKDLPELAAYAREKGMRAVISTNGTLIDREMAKKLKEVGLSYVGVSLDGIRETNDKFRGMKGAFDAALRGLHNCQEEGIKVGLRFTINKQNVRDIPAIFDLLEEEKIPRICFYHLVYAGRGSKMVNEDLSLEESRQAVDLILERTRKLHEKGFPAEVLTVDNHCDGPYLYMKLLKENPERAAEVFELLSMNQGNSSGIGIGCVSWDGAVHADQFWRHYSFGNVRERPFSEIWTDLSDELMAGLKNRKPLIKAHADRCARCKWLDVCNGNFRVRAEAVYGNVWADDPACYLTKEEIGYYEA
What is the function of this protein?
Involved in siroheme-dependent heme b biosynthesis.  Catalyzes the conversion of didecarboxysiroheme into Fe-coproporphyrin III by oxidative loss of two acetic acid side chains.
What are the official names of this protein?
Fe-coproporphyrin III synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily.
Protein: LPTD_BURCM
Sequence: MPPKPLFPNVFPGDGAPRKRRLALALLAVPGLVPAVSYAQLSGAAAQPQPLDSPWDLRLAPQLEDHPLKDGAKPAAFVIADHTSGTAEQDLAAKGSAELRRGDAVVKADALHYDQDTDMADAYGQVRVINGGTSFAGPEAHLKVEANQGFMTAPKYHFNVTGGSGSAERVDLLDSERSVFVNGTYTACQCATDPAWYIKGSRFDFDTGADEGTARNGVLFFQGVPIFASPWLTFPLSGERRSGLLPPTFSLNSNNGFELTLPYYFNIAPNRDLTITPRIISRRGVQTEASFRYLSPTYSGTLTANYLPDDRLAHRNRYAIYWQHQQNFGGGFGGYVYFNKVSDNTYPEDLGSTNEFINGTQTLYQQEAGLTYNNGPWSVLARYQHWQTLPPSIAPYSREPQLNVKYTKYNVGGFDFGAEADYSRFRITTADATEGDRIVFNPYIAYGVYGPGYFVVPKVQYHFASYDLNYLSSSTPNSPKRFTESIPTVSFDTGLIFDRSVRLFGQDFIQTLEPRLYYVYTPYRDQSNAPLFDTAESDFGLAEIYQPNTFVGNDRIADANRITAGLTSRFIDPRTGDERARFVIAQQYYFANQRVTLNSVQAPVQARHSDLIVGAALKLGSGFMSETAFQYNQNNNQLVKSSIGFGFSPGERRVINVGYRYTRANTTLDNQPINQFLVSAQWPLTRRLYAVGRFNYDLAANRVVDGLLGLQYDADCWALGVGAQRFANGVNSSGQQNSSTRFMMQLTLKGLSSIDNGLVAAFRAGVPGYTALPSAPPPMSRFSNYE
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: BCL7B_MOUSE
Sequence: MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNNTAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPASEVADEPPTLTKEEPVPVETQTTEEEEDSGAPPLKRFCVDQPVVPQTTSES
What is the function of this protein?
Positive regulator of apoptosis.  Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (By similarity).  Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (By similarity).  May play a role in lung tumor development or progression.
What are the official names of this protein?
B-cell CLL/lymphoma 7 protein family member B.
What is the protein family that this protein belongs to?
Belongs to the BCL7 family.
Protein: ODP2_RICCN
Sequence: MPIKILMPALSPTMTEGNLARWLKKEGDKVNPGEVIAEIETDKATMEVEAVDEGILAKIVIPQNSQNVPVNSLIAVLSEEGEEKTDIDAFIAKNNSVSPSPKTDANLPKPHENIANVEEQVTVIKHDVSRIFASPLAKRLAKMRNIRFESVKGSGPHGRIVKQDILSYTPSTAHNKIVSRNPEEYRLVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKFFSEDKSTRISVNDFIILAVAKALQEVPNANASWGEDAIRYYNNVDISVAVAIENGLVTPIVKNANQKNILELSREMKALIKKAKDNKLTPEEFQGGGFTISNLGMYGIKNFNAIINPPQSCIMGVGASAKRAIVKNDQITIATIMDVTLSADHRVVDGAVGAEFLVAFKKFIESPVLMLI
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
What are the official names of this protein?
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: REF2_YEAST
Sequence: MSAPVPQLVNISHALQASTIQQIRLDMVDFNKDCKLSSIQLARIDKYIDSLQAALNQFTKDNLHIERKEKNVTEADIQLYSGLKSMYLDYLNQLIKLKHEKQHHSTPPIANDVSLDFFVNQLPKFSPEERKNYIDNLILNKNSHNRLSKMDGLVDAVINLCVLDTSVAENVRSYMKLLDTLGFQKGSNSTGTKANLKKKLASSKAKIKDSEKEKEKEKDKSKVKMKTKLKPSPLLNNDDKNSSPSPTASTSSMKKLKSGLFNKNEAKSTESLPTSSKKKLSFSKYLNKDDADMTKLGTKRSIDVDFKVNPEASTVASNIISSSTSGSSTTTVATPASSEEPLKKKTKISVQDSNVQSILRNGKPKKARISSIKFLDDSQLIKVYGDDLPNQGLQVSPTQLKKILKPFKEGEPKEIILFEDMSIKLKPLDLMFLKNTNSDDYMDISETKGGPIHCETRTPLIYRKNFNHFNPDLNKRPPREPIEFDLNGNTNSTPTIAKAFGKNSLLLRKDRGGLPYKHVPIVKRNKYPPRPVH
What is the function of this protein?
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.  Negative regulator of poly(A) synthesis.  Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation.  REF2 is required for 3'-end formation of snoRNAs.
What are the official names of this protein?
RNA end formation protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: CPT6_SOLLC
Sequence: MNSLFVGRPIVKSSYNVYTLPSSICGGHFFKVSNSLSLYDDHRRTRIEIIRNSELIPKHVAIIMDGNRRWAKARGLPVQEGHKFLAPNLKNICNISSKLGIQVITAFAFSTENWNRSSEEVDFLMRLFEEFFEEFMRLGVRVSLIGGKSKLPTKLQQVIELTEEVTKSNEGLHLMMALNYGGQYDMLQATKNIASKVKDGLIKLEDIDYTLFEQELTTKCAKFPKPDLLIRTGGEQRISNFLLWQLAYSELYFTNTLFPDFGEEALMDAIFSFQRRHRRFGGHTY
What is the function of this protein?
Uses neryl diphosphate to catalyze the cis-prenyl chain elongation and produce the 15 carbon product (2Z,6Z)-farnesyl diphosphate.
What are the official names of this protein?
(2Z,6Z)-farnesyl diphosphate synthase CPT6, chloroplastic, Cis-prenyltransferase 6, SlCPT6.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Note=Localizes in punctuate patterns inside the chloroplasts.
Protein: CAN5_HUMAN
Sequence: MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV
What is the function of this protein?
Calcium-regulated non-lysosomal thiol-protease.
What are the official names of this protein?
Calpain-5, Calpain htra-3, New calpain 3, nCL-3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
Protein: NADD_ACIC1
Sequence: MTGRRARIGVMGGTFDPIHHGHLVAASEVASQFQLEEVIFVPTGQPWQKAERDIAPAEDRYLMTVIATASNPRFTVSRVDIDRPGPTYTIDTLRDLRAELAARGLTDPDLFFITGADALAKIMSWNRAEELLTMAHFVGVTRPGHRLDTPTGLPPDRVSLLEIPALAISSTECRERIRQNRPIWYLVPDGIVQYISKRGLYRRTDGGR
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.