PharMolix/UniProtQA huggingface dataset:
Protein: GREA_HYDCU
Sequence: MQRHPMTKEGADALQEELQHLKKVERPAVSNAIAEAREHGDLKENAEYHAAREQQGLMEARIKQIESLLGSVQIIDVTKLNPNGKVVFGSTVTILNVDTEEEVTYKIVGEEEADIKHNKISVNSPIARALIAKEEGEEITVKAPSGNIEYEIVEIQYV
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: ATMIN_MOUSE
Sequence: MAATEAAAADSAGPAPGVPATPASTRGAAAASSPWRPPESRLQGSRPRPARARAAAPVPPARELIQPTVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLTTAPKFYCCPIKGCPRGPDRPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHEEDCGKTFQCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMESYLQNQKLSSKTTEPLSDQAAPRQDAAEPDAPEVKPAASLEDSCSAHTKKQSVATPPRCPQKLLLPKPKVALVKLPVMQFSPVPVFVPTAESSAQPVVLGVDHSSAAGTVHLVPLSVGALILSLDSEACSLKESLPLSKIISPVVEPMNTGVQVNLGKSLCSPLQEVGSVCQRTSISSSNVQTDLTYASANLIPSAQWLGPDSSVSSCSQTDLSFDSQVSLPVSVHTQTLVPSSKVTSSIAAQTDAFIDACFQPGGVSRETQTSRMQNRTNDSVPVGHTGLCGDIFESVHASYSVPTDTIMSSSLVAETGTHGLPPQSDPKILGQVMEKSAPVLNFSTQNGLLPAHTMTDNQTQTIDLLSDLENILSSNLPGQTLDNRSLLSDTNPGPDAQLPAGSAQNSGIDFDIEEFLSASNIQTQTEESELSSMSTEPVLESLDIETQTDVLLSDPSTQPYGFRAGSGFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSMSTDSSDTETQTEGACPARHLPALESKVQLSSTETQTMSSGFEPLGNLFLTSNETQTAMDDFLLADLAWNTMESQFSSVETQTCAELHAVSSF
What is the function of this protein?
Transcription factor.  Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage.  Involved in regulating the activity of ATM in the absence of DNA damage.  May play a role in stabilizing ATM (By similarity).  Binds to the DYNLL1 promoter and activates its transcription.
What are the official names of this protein?
ATM interactor, ATM/ATR-substrate CHK2-interacting zinc finger protein, ASCIZ.
What are the subcellular locations of this protein?
Nucleus. Note=Nuclear, in discrete foci during G1 phase.
Protein: RU1C_NEUCR
Sequence: MPKFFCDYCDVYLTHDSMSVRKAHNSGRNHLRNVVDYYQQIGHEKAQSVIDSITSSYAAEGQAHANPMLPQNQPGGVPPGLGFPPPGAGVPPFPPFPGGMPPPFPGMPGGAPVPPPGAFGAPGVPGGIPPPGAPGARGMPPMPPFPGMPGAPAGIPGVPPPMPGPGGLPFPPPGGLPFPPPGAGNFPFPPPGAPGAFPGMPPFGAPGQGPPGADKR
What is the function of this protein?
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome.  U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing.  The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.  Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
What are the official names of this protein?
U1 small nuclear ribonucleoprotein C, U1 snRNP C, U1-C, U1C.
What is the protein family that this protein belongs to?
Belongs to the U1 small nuclear ribonucleoprotein C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUDI_SALCH
Sequence: MRQRTIVCPLIQNDGCYLLCKMADNRGVFPGQWALSGGGVEPGERIEEALRREIREELGEQLILSDITPWTFRDDIRVKTYADGRQEEIYMIYLIFDCISANRDICINDEFQDYAWVKPEELALYDLNVATRHTLALKGLL
What is the function of this protein?
Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
What are the official names of this protein?
Nucleoside triphosphatase NudI, Nucleotide diphosphatase NudI, Pyrimidine deoxynucleoside triphosphate diphosphatase, dCTP diphosphatase, dTTP diphosphatase, dUTP diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudI subfamily.
Protein: MURG_RHILW
Sequence: MSKGIVLLAAGGTGGHVFPAEALAFKLKERGYSVHLVTDSRAERYAGKFPAEEIHVVPSATIGSKNPVAVARSLWTLWSGMRAAKKLIQRLKPVIVVGFGGYPTVPPLLAATRLGVPTMIHEQNAVMGRANKALATRVQGIAGGFLPEGGGAFPEKTVTTGNPVRPAIIAAAEVPYTPSHPGEAFNLVVFGGSQGAQYFSKALPTAISLLDDALRLRLRITQQVRPEDMEMVGGCVAKLEMGADIAPFFTDMAERLAKAHLVICRSGASTVSEISVIGRPAVLVPYPHALDHDQAANAAALAATGGAKVIAQSELSPEKIAAILTAVMNDPEKLSHMAAAAKLAGKPDAANLLADMVEAIAAGRTIAELKRTRA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PCKA_SALHS
Sequence: MRVNNLTPQDLKAYGINDVQDIVYNPSYDTLYQEELNPGLEGYERGVLTNLGAVAVDTGIFTGRSPKDKYIVRDDTTRDTLWWSDKGKGKNDNKPLSQETWQHLKGLVTHQLSGKRLFIVDAFCGANADTRLSVRFITEVAWQAHFVKNMFIRPTDEELVGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERIQLIGGTWYGGEMKKGMFSVMNYLLPLKGIASMHCSANVGEKGDVAVFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYHAIRRDALLENVTVREDGTVDFDDGSKTENTRVSYPIYHIDNIVKPVSKAGHATKVIFLTADAFGVLPPVSRLTANQTQYHFLSGFTAKLAGTERGVTEPTPTFSACFGAAFLTLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAIIDAILNGSLDNAETFRLPLFDLAIPTELPGVDTHILDPRNTYASPEQWQEKATALAKLFIENFEKYTDTPAGEALVSAGPKL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3014_BACAC
Sequence: MKVIAVTGYKPFELGIFKNDHPGVECIKKALRRKLTAFVEGGLEWVIISGQLGVELWTAEVVFEIQVEYPDLKLAVFTPFLEQEEGWKEDNREYYEFILSQADHVDSITKRKYESPEQFKLKNQIFIEKSDALLAVYDEEKPGSPKYIVEAAKKKGEIENYHSYFILFSDLQDIIEEEQWNNAE
What are the official names of this protein?
UPF0398 protein BAMEG_3014.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: Y054_STAA8
Sequence: MKRLNKLVLGIIFLFLVISITAGCGIGKEAKIKKSFEKTLSMYPIKNLEDLYDKEGYRDDEFDKNDKGTWIIGSEMATQNKGEALKVKGMVLYMNRNTKTTKGYYYVNAIKNDKDGRPQENEKRYPVKMVDNKIIPTKEIKDKNIKKEIENFKFFVQYGNFKDLSKYKDGDISYNPEVPSYSAKYQLTNDDYNVKQLRKRYDIPTNKAPKLLLKGTGNLKGSSVGYKDIEFTFVEKKEENIYFSDGLIFKPSEDK
What are the official names of this protein?
Uncharacterized lipoprotein SAOUHSC_00054.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: FSLL_DICDI
Sequence: MITNKSKYYFFLILIFINFYLINCQEEYPIDQTGKCEPYIGDSQITKCSTFLPNINSIYVSANSTQKDSMKTLDNYFGLLLAVGSEKCKDSSLTYQTLCSMYLKECESFTDNSTLKTVSIPKRICRKTCNDVTKLCNIESLFNCSQNEPINNLPLCPLNYSIYDLSLVNGDSNYELQCYSPLSNDSIEIPVTNYCPFPLIYINSTDHSADEDRGYMFVSGNSNCVVPNPVPLYTPKQWDRLYDLSNSLSVLSCVGTLFLLFTFNILNKKINRFDRMNSLFNGSVFMMSLSGVIILFAGGPRALIKDGGARISVWQDPLCSATGFIFQLFSIAAILFWVVMSFELWYKIKFMTKKLDLKKYYIPFIIIVSLVFSIIPLATKNYRMIRGNMHCWVHTTKLQNSLFWIPLGIAITIGTIFIGLVMFEIHRIVSANSKGGVLKLEIKSILNVALIYLTFIYLFAFNFYMNGQEGVVYGQIESFYQCTLENDASECTIQGPSIGSLGFFIFCIRIYGVYCFILQGLNYRAYNIWKESIFFNNRFVSYIKNNILNIETSSTGSGGTSTTASATTTTTTKKHNGIDSLNIDSAFSKNNESDDEDDYDPYKKSKNNITLKDIEVSKS
What are the official names of this protein?
Frizzled and smoothened-like protein L.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: COBA2_MOUSE
Sequence: MERCSRCHRLLLFLPLVLGLSAAPGWAGAPSVDVLRALRFPSLPDGVRRSKGVCPGDVAYRVARPAQLSAPTRQLFPGGFPKDFSLLTVVRTRPGLQAPLLTLYSAQGVQQLGLELGRPVRFLYEDQRGRPQASAQPIFRGLSLADGKWHHVAVAVKGQSVTLIVDCKKRVTRPLPRSVHPVLDTHGVVIFGAHILDDEVFEGDVQELLVVPGVQAAYQSCGQKDLECEREQRDGPQTQKPHRAQRSPKKEPARLHKPQSQEPQKQPTESLYYDYEPPYYDVMTTGTAPDYQYPTPGEEEGVLESSPLPFLEEEQTDLQVSPTADSFQAEEYGEGGTDSPAGFYDYTYGYGDDYREETELGPALSAETAHSGAVAHGPRGLKGEKGEPAVLEPGMFVEGPPGPEGPAGLAGPPGIQGNPGPVGDPGERGPPGRAGLPGSDGPPGPPGTSLMLPFRFGSSGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSPGLKGESGDLGPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGEPGMKGDRGFDGLPGLPGEKGQRGDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPHGPKGSLGPQGEPGPPGQQGTPGAQGLPGPQGAIGPHGEKGARGKPGLPGMPGSDGLPGHPGKEGPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPGSRGEDGPEGPKGRTGPTGDPGPTGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPAGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGTAGESGPMGERGHSGPPGPPGEQGLPGTSGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNEGPAGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDGGPMGPPGPPGPRGPAGPNGADGPQGSPGGVGNLGPPGEKGEPGESGSPGVQGEPGVKGPRGERGEKGESGQAGEAGPPGPKGPTGDNGPKGNPGPVGFPGDPGPPGEAGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGTPGPEGRQGEKGAKGDPGAVGAPGKTGPVGPAGLAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLIGLIGPTGEQGEKGDRGLPGPQGSPGQKGETGIPGASGPIGPGGPPGLPGPSGPKGAKGATGPAGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRSVDGSKLIQDEEAVPTGGAPGSPAGLEEIFGSLDSLREEIEQMRRPAGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCARDAFRVFCNFTAGGETCVTPRDDVTQFSYVDSEGSPVGVVQLTFLRLLSVSAHQDVSYPCSGVSQDGPLKLRGANEDELSPETSPYVKEFRDGCQTQQGRTVLEVRTPVLEQLPVLDASFADLGAPTRRGGVLLGPVCFMG
What is the function of this protein?
May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
What are the official names of this protein?
Collagen alpha-2(XI) chain.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: MANB_SALMO
Sequence: MNNLTCFKAYDIRGRLGEELNEDIAWRIGRAYGEYLKPKTIVLGGDVRLTSEALKLALAKGLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGDTGLRDVQRLAEAGDFPPVNDAARGSYRQISLRDAYIDHLLAYISVNNLTPLKLVVNSGNGAAGPVIDAIEARLKALGAPVEFIKIHNTPDGTFPNGIPNPLLPECRDDTRKAVIEHGADMGIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKHPGAKIIHDPRLTWNTEAVVTAAGGTPVMSKTGHAFIKERMRTEDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGQSLGELVRDRMAAFPASGEINSRLAEPAAAIARVEAHFAEEAQAVDRTDGLSMSFADWRFNLRSSNTEPVVRLNVESRGDIPLMEARTKEILQLLNS
What is the function of this protein?
Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides.  This enzyme participates in synthesis of the LPS O antigen.
What are the official names of this protein?
Phosphomannomutase, PMM.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: PSB1_AERPE
Sequence: MSFAGATALGIRVEDGVVLAADKRMSYGGFILSRNFKKIFVINDRIGIAFAGLYGDMGGLVRIVEGQMRLASLETGKPATVRNVAKFLSSLLYSYKFFPFNVEAIVGGIDPGGEPKLYVLDPLGSIIEEDYVAAGTGATTAFGLLEHVYKRGMSLEEAKKAAVEALRASMARDAGTGDGIDVLVLPVSGKPSLETIKFRLVEG
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 1, 20S proteasome beta subunit 1, Proteasome core protein PsmB 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXNP_EMENI
Sequence: MGATATDIEKVPSAGTPDEPKAGETNVYVDTEAEKSFVRKVDFFVLPMLCLMYFFDCMDRSNLANAKTDGLEEDINLKGNEYSLLILLFYIPFGLFDLPWNLLIKRYSARIMLSLRRYAVTVVWGICALCQCAANNFGGLLAIRIILGVFEAGFFAGSTFYFTLFYTRNEMGFRLAVLQSFAVLASAFSGLISFGLFQINHSAVKGWQWLFIVEGAMTLIIGVIGFWWLPDTAQSAWFLTQRERDAASARLLRDTSAEIETKLELKAAFQTWSDWKFPIWAVITFSYPVAYATAMNFFPIIVARLGYSVVKTNLWTVAPNLVGAVVLLVVAKSSDIFRERSLHIIFSLTVSLVGMLILASIDVSHNKGVSYFACFLLASGAYIPTCLVHAWHNNNNTNENSRAANTGFFVGLGNIAGVLSAATFRTEYAPKYVPTLVATCACNGVCILATAFMGTWMRLENRRKDKEQGARIVAGQVETRMLADGEKSPEWRYFL
What is the function of this protein?
Major facilitator-type transporter, part of the hnx cluster involved in the purine degradation (PubMed:29212709).  The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism (PubMed:29212709).  The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid (PubMed:29212709).
What are the official names of this protein?
Major facilitator-type transporter hxnP, Nicotinate catabolism cluster protein hxnP.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YDA4_SCHPO
Sequence: MSYMHSLNLMLQNPSGIDKIAAILVNVARLDPASSKSTAQLVSMLNEFRCILRLPGLYKLIVNFRKDSSPETYMSNAINIGYYVTEGLAFLGGKQIISISKPLEDKLWLWSSRFWLLDTLLTIYQLLREKTEDEKEHQLDLASNLASLPLCIHWSVENGAGLHKHQIGVLGLFSAIVQTRKLILSLHNKRA
What are the official names of this protein?
Uncharacterized protein C1F12.04c.
Protein: RCF1_ASPFN
Sequence: MSSDPVPSSFEGNPQFEEETSLQKFRRRLKEEPLIPLGCAATSYALYRAYRSMKAGDSVEMNRMFRARIYAQFFTLIAVVVGGMYFKTERQQRKEFERMVEERKSQEKRDAWLRELEIRDKEDKDWRQRHAAMEAAAAEAGKKTAPHDAARSAIERSEEKSIGVLDAVKELLSRRN
What is the function of this protein?
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
What are the official names of this protein?
Respiratory supercomplex factor 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RCF1 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: TYSY_SHESA
Sequence: MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGDTNIAYLRENKVSIWDEWADENGDLGPVYGAQWRSWPTQSGDAIDQIAQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPRQLPTMTILRKPASIFDYQFEDFELTHYDPHPHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_LARHH
Sequence: MQEMNVKQFAGELKMQPEHLLEQLKSAGVNKTSINDALSHVDKERLLDFLRQGRNEGGRVTLKRKETSEVRANDASGRSRTIQVEVRKKRVLERPAEAARPAAAPAVAQEAPAAEMREPEARPQAPAAEPALKPADRVGAPAVRTERKPEPKPEPAKAEPARAAKPEPKPEPVKAEPAKAVAEPAPAAEATQPAAAPARPVSILSAEEIASREAEERRQAELRARQEALIRERQEREARRMAAKLAAQQKAQEAANPKPAAEKPAESRPARPAEGRSGARPAPAARPAAGGARPAPAAGAPAGAARPAGSGADDRRGAGKKTGGGNTDRDGGKKRGGLKTRGGDASSGWKSGSRKGKRQHQDNQHAFQAPAEPIVHEVMVPETITVADLAHKMAVKAAEVIKALMKMGMMVTINQVLDQETALIVVEELGHIGKAAKTDDPEAYLDVEDGNVVEAKLEHRAPVVTVMGHVDHGKTSLLDRIRKAKVAAGEAGGITQHIGAYHVDTPRGMITFLDTPGHEAFTAMRARGAKATDIVVLVVAADDGVMPQTIEAIHHAKAAGVPIVVAVNKIDKQGANPERIRQELVAQEVVPEDWGGDTQFVEVSAKQGLNIDGLLEAILLQAEVLELTAPVDAPAKGIIVEARLDKGRGSVATLLVQSGTLRKGDVLLAGTAFGRVRAMLDEDGKQIEEAGPSIPVEILGLSDVPGAGEDAMVLADEKKAREIANFRAGKYRDVRLAKQQAAKLENMFAQMAEGEVRSLPLIIKADVQGSYEALAGSLQKLSTDEVRVQILHSGVGGITESDVNLAAASNAVIIGFNTRADATARKVAEANGVDIRYYNVIYDAIDEVKSALSGMLAPEKKEEITGTAEVRQLFVVSKVGTIAGCMVIDGMIKRTSRIRVIRNHVVVHDGELDSLKRFKDDVKEVKQGYDCGIMLKGFNDLLEGDQLEAYEIVEVARSL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_EHRCJ
Sequence: MSTFTPTRNDWQLDEILELFHTAFNDLILQSHLLHRQFFSNNEVQISSLLNIKTGGCPENCKYCSQSAHYKTDLKKESLLDIESIKKAIQTAKKNGADRFCFAAAWRQVRDRDLEYICDIIDLIKSENLESCASLGMVTLEQAKKLKNAGLDFYNHNIDTSRDFYPNVTTTRSYDDRLTSLNNIHEAGINICSGGILGLGESVEDRAKMLLTLANLKEHPLSVPINRLVPIKGTPFENNAKIDNIDFIKTIAVARILMPKSYIRLAAGRMSMSEEMQALCLFAGANSIFYGEKLLTTPNADCNDDRNLLSKLGAKTKEPVFFNS
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: ASPD_METKA
Sequence: MKKLSLALVGAGGIGTTVLREIREGRLEGKVEPVLVCDRHPEKLKRIERWFPDCDTSTDLDDAMSAEADVLLEAASVEAAASLLPDALKRFDVIVMSVGALVLEEGLLSRCREVAEVTGHRLHVPSGAVGGLDVLRALRGRVREVTLTTIKPPKALNKDVSERTVLYEGSVRDAVRKFPKNINVAAAVSLAVGDPSLVTVRIVCDPEVSVNTHVIEVESSAGTYRFELRNEALPDNPKTSAVAAYSAVALIERMTEGIRVGT
What is the function of this protein?
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
What are the official names of this protein?
L-aspartate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the L-aspartate dehydrogenase family.
Protein: ARLY_LISIN
Sequence: MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLAGSLAHVAMLAKCGIISDSEASEITAGLKILQEKLALGELEFSTVNEDIHLNIEKLLHEEIGPVAGKLHTARSRNDQVATDMHLYLKEAVAEIIQSLKHLRAVLVQKAEANVETIMPGYTHLQHAQPISFAHHLLAYFGMFTRDLERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAVYENSLDGVSDRDFIIEFLSNSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLFGMLTVLKGLPLAYNKDLQEDKEGMFDTLETVHTSLDIFAGMIETMKVNADIMEESTQKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGIYLQDVAFSHYQEIHPLIEEDIYTVLASKTAVQKRNSYGGTGFDQIHVALANAKKTL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_HALOH
Sequence: MAIKKFKPTTPSRRFMTVSAFDEITRREPEKSLLAPLKKTGGRNSYGRVTVRHRGGGHKRRYRIIDFKRDKDGVPARVASIEYDPNRSARIALLHYVDGEKRYILAPNKLQVGDTVKSGEDAEIKPGNALKLKNIPVGTIIHNIELKPGKGGQLARAAGTMAQILAKEGKYAHIKLPSGEVRLISLECKATIGQVGNIDHENISIGKAGRKRWLGKRPHVRGVAMNPVDHPHGGGEGRTSTGRHPVTPWGKRTLGKKTRKRKASDKYIIRSRRARKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ADDA_BACCQ
Sequence: MIENWPKKPEGSQWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIINEENPVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDEPGSQHIRKQLSLLNKASISTIHSFCLQVIRGYYYMLDVDPRFRIANQTENELLKEEVLDDILEEEYGIEDNTIFFELVDRYTSDRSDDDLQRMILALHTESRAHPNPEKWLDKLVEAYDVEGKTIEDLVYASYLLEDVKFQLETAEQHIRKATELAMLPDGPAPRVETLQADLALLGTLSSAARESWTSVYEAMQNVSWQTLKRIKKSDYNEDVVKQVDSLRNKAKDEVKKLQEELFSRKPESFLRDFQDMHPVLEKLVQLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSEEGEMKPSAVALQYRNKFAEVLVDEYQDTNFVQESIIKFVTKDSESEGNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFTQEGLGGGMKIDLAKNFRSRHEVLAGTNFIFKQIMGEEVGEIDYDADAELKLGASYPEGEDVAAELLCIQQTEEEVIDGEEGAEVEKAQLEARLMAQRIKAMVDSGYEVYDRKTDSMRPVQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPMQDIPLAAVLRSPIVGLNDEELATLRAHGKKGSFYEVMSSFLKGAPLEEEKELHDKLEWFYNLLQGWREFARQQSLSDLIWKVYGETGYYDFVGGLPAGKQRQANLRVLYDRARQYEATSFRGLFRFLRFIERILERGDDMGTARALGEQEDVVRIMTIHKSKGLEFPVVFVAGLGRRFNTQDLMKRFLLHKDFGFGSQFIDPRKRIKYTTLSQLAIKRKMKMELIAEEMRVLYVALTRAKEKLILIGTVKDATKEMEKWLDAREHSEWLLPDHIRAGASCYLDWIAPSLYRHRDSEILLELGQGSVPDEIYGYDTSWKVEVVDGNTLLAPEPVQEEKQELLEALREKKAVPLESERKEEVYDRLMWKYGYEEATSHRAKQSVTEIKRNYQSEEGSDNAFIKKLRAPIRTRPRFMEKKGLTYAERGTAVHAVMQHVDLKKPITEEVIREQIAGMVNKELLTFEQAEEIAIEKVISFFDSDLGKRVLAAKSVEREVPFTMMLAAEEAYQDWQGQSGESILVQGVIDCMIEEEDGITLIDFKTDTIEGKFPGGFEQAKPILEERYKVQLSLYAKALEKSLQHPVKEKCLYFFDGNHVVKIEE
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: HIS7_PICPA
Sequence: MTGEHKRSSLIKRITNETKIQIALSLDGGPVSLAQSLFKDKDYSAEHAAQATSSQFISVNTGIGFLDHMLHALAKHGGWSVIIECVGDLHIDDHHSAEDTGIALGMAFKEALGHVRGIKRFGSGFAPLDEALSRAVIDMSNRPYAVVDLGLKREKIGDLSCEMIPHVLESFAQGAHVTMHVDCLRGFNDHHRAESAFKALAIAIKEAISSNGTDDIPSTKGVLF
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
Protein: KDSB_ECOBW
Sequence: MSFVVIIPARYASTRLPGKPLVDINGKPMIVHVLERARESGAERIIVATDHEDVARAVEAAGGEVCMTRADHQSGTERLAEVVEKCAFSDDTVIVNVQGDEPMIPATIIRQVADNLAQRQVGMATLAVPIHNAEEAFNPNAVKVVLDAEGYALYFSRATIPWDRDRFAEGLETVGDNFLRHLGIYGYRAGFIRRYVNWQPSPLEHIEMLEQLRVLWYGEKIHVAVAQEVPGTGVDTPEDLERVRAEMR
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP2C6_RAT
Sequence: MDLVMLLVLTLTCLILLSIWRQSSGRGKLPPGPIPLPIIGNIFQLNVKNITQSLTSFSKVYGPVFTLYFGTKPTVILHGYEAVKEALIDHGEEFAERGSFPVAEKINKDLGIVFSHGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQNRFDYKDQDFLNLMEKLNENMKILSSPWTQFCSFFPVLIDYCPGSHTTLAKNVYHIRNYLLKKIKEHQESLDVTNPRDFIDYYLIKWKQENHNPHSEFTLENLSITVTDLFGAGTETTSTTLRYALLLLLKCPEVTAKVQEEIDRVVGKHRSPCMQDRSRMPYTDAHDHEVQRFIDLIPTNLPHAVTCDIKFRNYLIPKGTTIITSLSSVLHDSKEFPDPEIFDPGHFLDGNGKFKKSDYFMPFSAGKRMCAGEGLARMELFLFLTTILQNFKLKSVLHPKDIDTTPVFNGFASLPPFYELCFIPL
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 2C6, CYPIIC6, Cytochrome P450 PB1, PTF2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.