PharMolix/UniProtQA huggingface dataset:
Protein: MDH_BURM1
Sequence: MAKPAKRVAVTGAAGQIAYSLLFRIANGDLLGKDQPVILQLLDLPQAQAAVKGVVMELDDCAFPLLAGVVITDDPKVAFKDADVALLVGARPRSKGMERKDLLSANAEIFTVQGAALNEVASRDVKVLVVGNPANTNAYIAMKSAPDLPKKNFTAMLRLDHNRALSQLAAKSGKPVASIEKLAVWGNHSPTMYPDFRFATAEGESLLKLINDDEWNRNTFIPTVGKRGAAIIEARGLSSAASAANAAIDHVRDWVLGTNGKWVTMGIPSDGSYGIPEDIIYGVPVTCENGEYKRVEGLEIDAFSREKMDATLAELLEERDGVAHLLKN
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: TREF_ECOSE
Sequence: MLNQKIQNPNPDELMIEVDLCYELDPYELKLDEMIEAEPEPEMIEGLPASDALTPADRYLELFEHVQSAKIFPDSKTFPDCAPKMDPLDILIRYRKVRRHRDFDLRKFVENHFWLPEVYSSEYVSDPQNSLKEHIDQLWPVLTREPQDHIPWSSLLALPQSYIVPGGRFSETYYWDSYFTMLGLAESGREDLLKCMADNFAWMIENYGHIPNGNRTYYLSRSQPPVFALMVELFEEDGVRGARRYLDHLKMEYAFWMDGAESLIPNQAYRHVVRMPDGSLLNRYWDDRDTPRDESWLEDVETAKHSGRPPNEVYRDLRAGAASGWDYSSRWLRDTGRLASIRTTQFIPIDLNAFLFKLESAIANISALKGEKETEALFRQKASARRDAVNRYLWDDENGIYRDYDWRREQLALFSAAAIVPLYVGMANHEQADRLANAVRSRLLTPGGILASEYETGEQWDKPNGWAPLQWMAIQGFKMYGDDLLGDEIARSWLKTVNQFYLEQHKMIEKYHIADGVPREGGGGEYPLQDGFGWTNGVVRRLIGLYGEP
What is the function of this protein?
Hydrolyzes trehalose to glucose.  Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
What are the official names of this protein?
Cytoplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_NEIMB
Sequence: MYIGSSMDIQTILEKTLPGLGYELVDFELTAQGTLRVFIDKESGITVEDCATVSNHLSRVFMVEDIDYKNLEISSPGLDRPLKKAADFVRFAGQNAKIKTRLPIDGQKNFIGKIEGCENDTVTVSFDGKTVQIELGNIDKARLRPEFKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOE_MICOH
Sequence: MKALWAVLVVTLLAGCLAEGDPELEPEVTDQLGWQTNQPWEQALGRFWDYLRWVQTLSDQVQQELQTSQVTQELTVLMEDTMTELKAYKKELEEQMGPMAEETRARLAKEVQAAQSRLGADMEDLRNRLGLYRNEVQTMLGQSTEELRARLTTHLRKLRKRLMRDAEDLQKRLAVYKAGAREGAERGVGAIRERLGPLVEQGRQRTANLGAGAAQPLRERAQALGARIRGRLEEVGNQARDRLEEVREQMEEVRAKVEEQAQQMRLQAEIFQTRLKGWFEPLVEDMQRQWANLMEKIQASVATNPIPPSSVPQESQ
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: RL29_CORK4
Sequence: MATGTPAHELRELSAEELTTRLHEAKEELFNLRFQNATGQLTNNRRLGTVKRDIARIHTVIRERELGLSSAPGDEA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: DNLJ_STRP7
Sequence: MNKRMNELVALLNRYATEYYTSDNPSVSDSEYDRLYRELVELETAYPEQVLADSPTHRVGGKVLDGFEKYSHQYPLYSLQDAFSREELDAFDARVRKEVAHPTYICELKIDGLSISLTYEKGILVAGVTRGDGSIGENITENLKRVKDIPLTLTEELDITVRGECYMPRASFDQVNQARQENGEPEFANPRNAAAGTLRQLDTAVVAKRNLATFLYQEASPSTRDSQEKGLKYLEQLGFVVNPKRILAENIDEIWNFIQEVGQERENLPYDIDGVVIKVNDLASQEELGFTVKAPKWAVAYKFPAEEKEAQLLSVDWTVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYIAEKDIRKDDTVIVYKAGDIIPAVLRVVESKRVSEEKLDIPTNCPSCNSDLLHFEDEVALRCINPRCPAQIMEGLIHFASRDAMNITGLGPSIVEKLFAANLVKDVADIYRLQEEDFLLLEGVKEKSAAKLYQAIQASKENSAEKLLFGLGIRHVGSKASQLLLQYFHSIENLYQADSEEVASIESLGGVIAKSLQTYFATEGSEILLRELKETGVNLDYKGQTVVADAALSGLTVVLTGKLERLKRSEAKSKLESLGAKVTGSVSKKTDLVVVGADAGSKLQKAQELGIQVRDEAWLESL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: HPPA_RHOPA
Sequence: MTALWVIVLCGALSIVYAIWATSSVLAADQGNARMQEIAGAVREGAQAYLKRQYMTIAIVGVVIFALLAYFLGILVAIGFAIGAILSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELAFKAGAITGLLVAGLALLGVTLYFIYLIHFAGLQANSRTVVDALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAVATMVLAAIFFGSATPDQLQSVMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIATGVLSLVGVGVVIHQLIGFGPLPGVSYTGLALFECGIVGLAVTGLIIWITEYYTGTDFRPVKSIAQASVTGHGTNVIQGLAISMESTALPAIVIIAGILITYSLAGLFGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRKSTDALDAVGNTTKAVTKGYAIGSAGLGALVLFAAYNEDLKFFIAQKSPYFVGVAPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAVGRAAGAIVEEVRRQFREKPGIMKGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIFVYFAIYAIAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMTSGGGAWDNAKKYIEDGHHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH
What is the function of this protein?
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane.  Generates a proton motive force.
What are the official names of this protein?
K(+)-insensitive pyrophosphate-energized proton pump, Membrane-bound proton-translocating pyrophosphatase, Pyrophosphate-energized inorganic pyrophosphatase, H(+)-PPase.
What is the protein family that this protein belongs to?
Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ZAPD_BURCJ
Sequence: MILYEYPFNERIRTLLRLEDLFERFAFFLAQEDPREHHVALTTLFEIAEVTGRADLKSDLMKELERQRQTLAPFRGNPGIEQNALEAVLGEIEQTLANLAQMQGKTGQHLVDNEWLASIRSRAVIPGGTCKFDLPSYYAWQQWPAEQRRQDIAKWVLPMLPLRDAAAIVLRLARESGQASKVMAMQGSYQQMLSGRTYQLMQVRVAPELRVIPEASANKYMLWVRFTMQDGDVRPRAVDIDVPFHLTLCNL
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: DAPF_YERPN
Sequence: MQFSKMHGLGNDFMVVDAVTQNVYFSPELIRRLADRHTGVGFDQMLVVEPPYDPELDFHYRIFNADGSEVSQCGNGARCFARFVRLKGLTNKREISVSTQTGRMILSVTEDEQVCVNMGEPDFEPQTVPFRAAKAEKTYILRAAEHTVLCGVVSMGNPHCVMQVDDVSVANVALLGPVLENHERFPERANIGFMQVVSRDHIRLRVYERGAGETQACGSGACAAVAVGVVQDLLNENVHVELPGGSLHIRWQGPGHPLYMTGPATHVYDGFIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: API11_SOLTU
Sequence: ESPLPKPVLDTNGKELNPNSSYRIISIGRGALGGDVYLGKSPNSDAPCPDGVFRYNSDVGPSGTPVRFIPLSGGIFEDQLLNIQFNIATVKLCVSYTIWKVGNLNAYFRTMLLETGGTIGQADSSYFKIVKLSNFGYNLLYCPITPPFLCPFCRDDNFCAKVGVVIQNGKRRLALVNENPLDVLFQEV
What is the function of this protein?
Inhibitor of cathepsin D (aspartic protease) and trypsin (serine protease).  May protect the plant by inhibiting proteases of invading organisms.
What are the official names of this protein?
Aspartic protease inhibitor 11, Cathepsin D inhibitor PDI.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.
What are the subcellular locations of this protein?
Vacuole.
Protein: PHSG_AQUAE
Sequence: MEEEKVKEGLWELAYNLWWTWNPPAKELFRSIDPLLWKETKENPIELLRKTKLLENKLKDEDFISHFKYVYSLYKTYMNRHSKYEDTYKKPIVFLSPEYGLHHTLLIYAGGLGFLAGDILKESSDLGFPLIGVGFMYPQGYVKQRIRVDGWQEDLDAQNQKELMPVKKVLDKEGKWLKCYVYVRDEKVYFGVWEVNVGKTKLYLLDTNVEENTPWNREISSRLYVPDKDLRLRQQIVLGFGTVILLEKLGIDAGGFHINEDYPSFVFLAEIFKLLKKGLTWDKAIEEVRKISLFTTHTPLRVAVNTYPFHMIEEQFLFVKDVYGIDVKKVLELGTNPEDPSEGFNSTIMSLRLAKYVNAVSKRHQEVSSKMWSFLFKEKENPIDYVTNGVHFPTWICSDLRRLYEEYLGENFVELHDHKSLWELIRDIPDEELWEYHIRNKERLIEHIKDRARERWVKEKADPSILMAEGLFLDSDVLTVGFARRMTGYKRPDLIFTDVERLKKIVNDSERPVQIIFAGKAHPADIEGKKIIQRIFNFAKDPEFGGRIAFVEDYDELLAHYMVRGVDVWLNNPLPPLEACGTSGMKASMNGVLHLSILDGWWIEGYNGKNGWAFGDYEVEGDRNRADAEAIYNILENEVIPLYYERDERGVPVKWISMMKEAIKSITPNFCSRRMLKDYINKFYSKILKEEG
What is the function of this protein?
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism.  Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates.  However, all known phosphorylases share catalytic and structural properties (By similarity).
What are the official names of this protein?
Glycogen phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the glycogen phosphorylase family.
Protein: MINE_HELPJ
Sequence: MSLFDFFKNKGSAATATDRLKLILAKERTLNLPYMEEMRKEIIAVIQKYTKSSDIHFKTLDGNQSVETIEVEIILPK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity).
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: PUR2_SCHPO
Sequence: MEPIIALLIGNGGREHTIAWKLCESPLISKVYVAPGNGGTASNGAESKMENVNIGVCDFEQLVKFALDKDVNLVIPGPELPLVEGIEGHFRRVGIPCFGPSALAARMEGSKVFSKDFMHRNNIPTAVYKSFSNYDHAKSFLDTCTFDVVIKADGLAAGKGVIIPKTKKEAFEALESIMLNEEFGSAGKNVVIEELLEGEELSILTFSDGYTCRSLPPAQDHKRAFDGDKGPNTGGMGCYAPTPVASPKLLETVQSTIIQPTIDGMRHEGYPLVGILFTGLMLTPSGPRVLEYNVRFGDPETQAVLPLLESDLAEIILACVNHRLDAIDIVISRKFSCAVVCVAGGYPGPYNKGDIITFDALKDKNTRIFHAGTSIRDGNVVTNGGRVLAVEATGDSVEAAVRLAYEGVKTVHFDKMFYRKDIAHHALNPKRKTREILTYENSGVSVDNGNEFVQRIKDLVKSTRRPGADADIGGFGGIFDLKQAGWNDPLLVSATDGVGSKLLIALSLNKHDTVGIDLVAMNVNDLVVQGAEPLIFLDYFATGSLDLKVSTSFVEGVVKGCKQAGCALVGGETSEMPGLYHDGHYDANGTSVGAVSRDDILPKPESFSKGDILLGLASDGVHSNGYSLVRKIVEYSDLEYTSVCPWDKNVRLGDSLLIPTRIYVKPLLHVIRKNIVKGMAHITGGGLVENVPRMLPSHLNAIIDVDTWEVPEVFKWLKDAGNVPISDMARTFNMGIGMVVAVASEDAEETMKELTSVGETVYRIGQLVDKESSSERCHLVNLNKWETF
What is the function of this protein?
Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
What are the official names of this protein?
Bifunctional purine biosynthetic protein ADE1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RNZ_MYCSK
Sequence: MIEVTLLGTGSPVPDARRAGPSTLVRAGGHAFLVDCGRGVQLRMAAAGIAANGLSALLLTHLHSDHIADLGDLLITRWVTTFTDQVPLQIIGPPGTAETVTAMLAAFGRDIGYRIAHHPDLTAPPPVEVHEVTEGVAWDHDGVTVRVAPTDHRPVAPTIGFRVEHADASVVLAGDTVPCATLDALAAGAGALVHTAIRKDLVELAPQQRVREVCEYHSSVEEAAETAERAGVGILVLTHYLPPIAPGQEADWRARAATAFPRQIELGDDLHRVEVHPGVCVKPAG
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: RK23_ANTAG
Sequence: MDKVKYPVLTEKTIRLLERNQYCFDVDLKASKTEIKQWIQDFFKVKVVAMNSHRPPKKKKRIGPVLGYPVRYKRMIITLESNYSIPLFLNK
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DLG3_MOUSE
Sequence: MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASSGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPGWWPECTCTNRDWYEQASPAPLLVNPEALEPSLSVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSIHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVTYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIFDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL
What is the function of this protein?
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
What are the official names of this protein?
Disks large homolog 3, Synapse-associated protein 102, SAP-102, SAP102.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
Protein: TRPG_LACLA
Sequence: MILIIDNYDSFTYNLVQYVGVLTDVAVVKNDDDSLGNMAEKADALIFSPGPGWPADAGKMETLIQQFAGQKPILGICLGFQAIVEVFGGKLRLAHQVMHGKNSQVRQTSGNLIFNHLPSKFLVMRYHSIVMDEAVALPDFAITAVATDDGEIMAIENEKEQIYGLQFHPESIGTLDGMTMIENFVNQVNENKESSNEK
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
What are the official names of this protein?
Anthranilate synthase component 2, AS, ASII, Anthranilate synthase, GATase component, Anthranilate synthase, glutamine amidotransferase component.
Protein: VTI1B_BOVIN
Sequence: MATSAASSEHFEKLHEIFRGLHEDLRGVPERLLGMAGTEEKKKLIRDFDEKQQEANETLAEMEEELRYAPLSFRNPMMSKLRTYRKDLAKLHREVRSTPLTATPGARGDMKYGTYAVENEHMNRLQSQRALLLQGTDSLNRATQSIERSHRIAAETDQIGSEIIEELGEQRDQLERTKSRLVNTSENLSKSRKILRSMSRKVTTNKLLLSIVILLELAILGGLVYYKFLRRH
What is the function of this protein?
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane.  These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.  May be concerned with increased secretion of cytokines associated with cellular senescence.
What are the official names of this protein?
Vesicle transport through interaction with t-SNAREs homolog 1B.
What is the protein family that this protein belongs to?
Belongs to the VTI1 family.
What are the subcellular locations of this protein?
Early endosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane. Cytoplasmic granule. Recycling endosome membrane; Single-pass type IV membrane protein.
Protein: MUTH_HAES1
Sequence: MTALTPPQYEAELLQRAKSIAGLTFAELAEELNLVVPPDLKRDKGWVGMLIETALGATAGSKAEQDFSHLGIELKTIPVNQQGYPLETTFVSLAPLAQNSGVTWHSSHVRYKLSKVLWIPIEGERQIPLAERHVGVPILWQPSSSQEQRLRQDWEELMDYIVLGKLTEITARIGEVLQLRPKGANSRALTKGIGKNGEIIDTLPLGFYLRKEFTAEILHDFLMD
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAAU_ECOLI
Sequence: MQPSRNFDDLKFSSIHRRILLWGSGGPFLDGYVLVMIGVALEQLTPALKLDADWIGLLGAGTLAGLFVGTSLFGYISDKVGRRKMFLIDIIAIGVISVATMFVSSPVELLVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSISFIAAMWYVGATCADLVGYWLYDVEGGWRWMLGSAAIPCLLILIGRFELPESPRWLLRKGRVKECEEMMIKLFGEPVAFDEEQPQQTRFRDLFNRRHFPFVLFVAAIWTCQVIPMFAIYTFGPQIVGLLGLGVGKNAALGNVVISLFFMLGCIPPMLWLNTAGRRPLLIGSFAMMTLALAVLGLIPDMGIWLVVMAFAVYAFFSGGPGNLQWLYPNELFPTDIRASAVGVIMSLSRIGTIVSTWALPIFINNYGISNTMLMGAGISLFGLLISVAFAPETRGMSLAQTSNMTIRGQRMG
What are the official names of this protein?
Putative metabolite transport protein YaaU.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NTPPB_PECAS
Sequence: MQQIVLASTSPYRKALLEKLTVPFVCASPDIDETPRIGENAIDLVIRLAESKARALATHYTNHLIIGSDQVCVLGNSITGKPHNKINATRQLQQASGKCVSFFTGLALFNSATQSIQSIAEPFDVYFRTLTEAEIDGYLEKEQPWNCAGSFKSEGLGITLFERLSGRDPNTLIGLPLIALTQMLQKEGLNPLTVRNE
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_DESDA
Sequence: MTTVSSDRIRIKLKAYDYRILDKAVAEIVDTARNTGAGVAGPIPLPTNIHKYTIQRSVHVDKKSREQFEMRIHKRLMDILEPTQQTVDALGKLSLPAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: DED1_PHANO
Sequence: MAEQLDMGRLNLNDSQHAPQNGFNGERSAYIPPHLRGRPQGGPPPMNAAPPMMNGGGGVGGSAWGPAPGGPSPAPPARFDGPPPGQMNGGGNWANANAQAFTPRGRDGPQGGGGWGGAAPGKFDPSAYGKPGGGGGGSARGSGDGQWKDGKHVPGPSNPRVERELFGVPNDPSKQQTGINFEKYDDIPVEASGQGVPEPVTRFTNPPLDDHLLSNIELSGYKVPTPVQKYSIPIVMGGRDLMACAQTGSGKTGGFLFPILAQAFQNGPSPPPTAQAGGYGRQRKAYPTSLILAPTRELVSQIFDEARKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLASIKYLVLDEADRMLDMGFEPQIRRIVEGEDMPPTAGRQTLMFSATFPRDIQMLARDFLKEYIFLSVGRVGSTSENITQKIEYVEDADKRSVLLDILHTHGAGLSLIFVETKRMADSLSDFLINQGFPATSIHGDRTQREREKALEMFRSGRCPILVATAVAARGLDIPNVTHVVNYDLPTDIDDYVHRIGRTGRAGNTGIATAFFNRGNRGVVRDLLDLLKEANQEVPSFLESIAREGSGFGGGGGRGGRGGGRGRGNAATRDVRRMGGGGGAGGFGGGGWGGAPQGGYGGGYGGAPAGGYAPPSGGAYGGGGGGGGGGGYGGGYGNPSGPGGNSWW
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DED1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_STRMU
Sequence: MSQEEIKDLTLLGNQKTNYNFDYDLNILEAFDNRHQDNDYFIKFNCPEFTSLCPITGQPDFATIYLSYIPDKKCVESKSLKLYLFSYRNHGDFHENCINTIGKDLVDLLQPRYLEVWGKFTPRGGISIDPYYNYGRPNTKYEEMAAYRLMNHDLYPETIDNR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VDAC1_ORYSJ
Sequence: MVGPGLYPEIGKKARDLLYRDYQTDHKFTLTTYTSNGVAITATSTKKADLIFGEIQSQIKNKNITVDVKANSDSNVVTTVTVDELTPGLKSILSFAVPDQRSGKFELQYSHDYAGVSASIGLTASPVVNLSSVFGTKALAVGADVSLDTATGNLTKYNAGLSFSNDDLIASLNLNNKGDSLTASYYHIVNHSATAVGAELTHSFSSNENSLTFGTQHTLDPLTVVKARFNNSGKASALLQHEWRPKSVWTISAEVDTKAIDKSSKVGIAVALKP
What is the function of this protein?
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.  The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.  The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).
What are the official names of this protein?
Mitochondrial outer membrane protein porin 1, Voltage-dependent anion-selective channel protein 1, OsVDAC1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1) family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane.