PharMolix/UniProtQA huggingface dataset:
Protein: CC120_MOUSE
Sequence: MEVKGQLISSPTFTAPAALFGEAAPLVKSDRLRGLLDRQRALQEALSVKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHPNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSAGALVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHSRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYGGAFTDG
What is the function of this protein?
Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092).  Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092).  Recruits NIN and CEP170 to centrosomes (PubMed:28422092).  Also required for neurite growth (By similarity).  Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth (By similarity).
What are the official names of this protein?
Coiled-coil domain-containing protein 120.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm. Cell projection, neuron projection. Cell projection, growth cone. Endosome. Note=Localizes to the subdistal appendages of mother centrioles and proximal ends of both centrioles in interphase cells (By similarity). Recruited to subdistal appendages by ODF2 (By similarity). In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas (By similarity). Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells (By similarity).
Protein: MYG_MAKNI
Sequence: MADFEMVLKHWGPVEADYATHGNLVLTRLFTEHPETQKLFPKFAGIAKADMAGNAAISAHGATVLKKLGELLKAKGSHAAIIKPMANSHATKHKIPIKNFELISEVIGKVMHEKAGLDAAGQKALKNVMTTIIADIEANYKELGFTG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: QUEC_SHELP
Sequence: MSKAVVVFSGGQDSTTCLIQALNQYDEVHAVTFDYGQRHSEEIATAAKLAKDLKVDSHKILDVTVLNELAISALTRDAIPVSNELMDNGLPNTFVPGRNILFLTLAGIYAYQLGAESVITGVCETDFSGYPDCRDSFIKAMQSALEQGMDRELKLVTPLMWLNKAQTWALADKYHSLELVRDQTLTCYNGIVGSGCGTCPACLLRAKGLNDYLDDKAGVMAELDAKC
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RSGA2_VIBVY
Sequence: MNNTMTSSQPYTLTQLGWKPFFQQQLTLEDYENTQICRIVAHHRSGYQLCSEQGRFHLAIHHAQPKMTVGDWVLLDEQQQFKRLLERQSELSRKAAGSKIAEQLIATNVDTLFIVCSLNDDFNLSRIERYLSIAKEAHIEPVVVLTKADLSPQAEQNITQVQQLSATLWVEAVNALDPASVSALQPWCTKGRTVAFIGSSGVGKSTLTNTLLGEETQQTGGIREDDSKGRHTTTARSVHMIPDGALIIDTPGMRELQLADCSEGVSETFAEIETLAQHCRFKDCQHQQEPGCAVQQAINNGTLEARRLQNYFKLQREQAYNASTFAEQRNRMKQFGKMCRHVQSDKQKLKTTY
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURP_SULTO
Sequence: MYILTIGSHSSLQILHGAKKEGFKTALVTPEKRVKFYKQFTFIDEVYGYKNEDEAVDYINDFANNGILIPHGSLVEYIGPERVNKIKTKIFGNRNLFEWEANQKKKMSLLKSAKIKIPEQFENPEDIDRLVIIKLPGAKGGKGYFIARNKSEAKEGLNKLLEQKMIRSIDEVIIQEYVIGVPMYFQFFNSIILNRLEIMGIDIRYETNIDGLRRLPADIKIDPTLVVVGNIPAVARESLLPLVYEYGENFVNTVKELVPPGMIGPFCLESVVTDQGDIVVFEFSGRIVAGTNLYVNGSPYSWLYWDEPMSVGRRISREIKLAINSNKLEQVLT
What is the function of this protein?
Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
What are the official names of this protein?
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: DEF_PELUB
Sequence: MSVKSILTEPNKLLRQISKPVENVGDEERRLMDDMLDTMYAAPGIGLAAIQIGVPKRIIVMDISRDEDKKEPRYFVNPVIKNKNDITSKYEEGCLSVPDQFAEIERPNECEVEYLDYNGKKQLLKADGLLATCIQHEMDHLEGVLFIDYLSKLKKSMIIKKLSKIKSNRIIV
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: GLYA_LISMC
Sequence: MVYLQKQDKEVFDAIKLELGRQRANIELIASENFVSEQVMEAMGSVLTNKYAEGYPGKRYYGGCEFVDIVEDLARDRAKKLFGAEYANVQPHSGAQANMAVYHTVLEPGDTVLGMNLSHGGHLTHGSPVNFSGVLYNFVEYGVREDTKEIDYDIVREAALKHKPKMIVAGASAYPRKIDFAKFREIADEVGAYLMVDMAHIAGLVAAGLHQNPVPYADFTTTTTHKTLRGPRGGMILAKAEWEQKLNKSIFPGIQGGPLMHVIAAKAVAFGEALQPEFTAYCEQIIRNSKKLAETLQANDVAVLTGGSDNHLLLIDLKPLGLTGKAAEKVLDEVGITVNKNTIPFETESPFVTSGIRVGVAAVTTRGFDEVAIEKVGVLISEVLHNLENEEVLADVKARVATLTNEYPLYPSL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 4HYPE_ROSAI
Sequence: MRVIDSHTAGEPTRVVLDGGPDLGSGTLAERAARLEAEHLDFCASVVLEPRGHDAIIGALLVPPSDPACAAGVIYFNNLQNLGMCGHATIGLGVTLAHLGRIRPGRHRFETPVGVVEIDLIDANTVSVVNIESYRLAKDVTVEVEGVGPVTGDVAWGGNWFFLVKNSPIALTGANIRPLTDLTLKIRTALEKAGVTGKDGAWIDHIELFGPAEDPAAQSRNFVLCPGGAYDRSPCGTGCSAKLACLAADGALAPGQDYLQESVIGSTYKISYQPGPGGGVIPTITGQAFVTSDATLIFNPADPYRSGIRL
What is the function of this protein?
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp).  May be involved in a degradation pathway of t4LHyp, which would allow L. aggregata to grow on t4LHyp as a sole carbon source.  Displays no proline racemase activity.
What are the official names of this protein?
4-hydroxyproline 2-epimerase, 4Hyp 2-epimerase, 4HypE.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: ALGL_PSEPF
Sequence: MRNPKLKTLLAPTLLGLAIFAGTAQAAAPLRPPQGYFAPVDKFKTGDKSEGCDAMPTPYTGPLQFRSKYEGSDKARATLNVQSEKAFRDTTKDITTLERGTAKRVMQFMRDGRPEQLDCTLNWLTAWAKADALMSKDFNHTGKSMRKWALGSMASSYIRLKFSDSHPLAQHQQEAQVIEAWFSKMADQVVSDWDNLPLEKTNNHSYWAAWSVMATSVATNRRDLFDWAVKEYKVGVNQVDADGFLPNELKRQQRALAYHNYALPPLAMIASFAQVNGVDLRQENNGALKRLGDRVLAGVKDPDQFEKKNGKEQDMTDLKQDMKFAWLEPFCTLYTCSPDVIEKKHGMQPFKTFRLGGDLTKVYDPSHEKGNKGS
What is the function of this protein?
Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism.  May serve to degrade mislocalized alginate that is trapped in the periplasmic space.
What are the official names of this protein?
Alginate lyase, Poly(beta-D-mannuronate) lyase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 5 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RNH2_SHELP
Sequence: MAIYKQITAEQVEALCSGFYAGVDEVGRGPLVGDVVTAAVVLDPNNPIEGLNDSKKLSEKKRDALYEEILAKALDVSVGRCSPLEIDELNILHATMLAMQRAVAGLRARPDRVLIDGNRVPDFTDETLEGHAVIKGDGLIPAISAASIVAKVVRDREMEALDERYPEYGFAKHKGYPTKAHFEALEAHGVLAEHRKSFRPVKERLEAC
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMK1_HUMAN
Sequence: MELWGRMLWALLSGPGRRGSTRGWAFSSWQPQPPLAGLSSAIELVSHWTGVFEKRGIPEARESSEYIVAHVLGAKTFQSLRPALWTQPLTSQQLQCIRELSSRRLQRMPVQYILGEWDFQGLSLRMVPPVFIPRPETEELVEWVLEEVAQRSHAVGSPGSPLILEVGCGSGAISLSLLSQLPQSRVIAVDKREAAISLTHENAQRLRLQDRIWIIHLDMTSERSWTHLPWGPMDLIVSNPPYVFHQDMEQLAPEIRSYEDPAALDGGEEGMDIITHILALAPRLLKDSGSIFLEVDPRHPELVSSWLQSRPDLYLNLVAVRRDFCGRPRFLHIRRSGP
What is the function of this protein?
N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L.
What are the official names of this protein?
MTRF1L release factor glutamine methyltransferase, HemK methyltransferase family member 1, M.HsaHemKP.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y7269_DICDI
Sequence: MKLNAFHLVVVVLIVSIFSVSSEDQTNGDIEYIDSNKISSYNDELCKDI
What are the official names of this protein?
Putative uncharacterized protein DDB_G0275685.
What are the subcellular locations of this protein?
Secreted.
Protein: NUDC_BOVIN
Sequence: MGGEQEEDRFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFVGGEEGMAEKLITQTFNHHNQLAQKARREKRARQETERREKAERAARLAKEAKSETSGPQIKELTDEEAERLQLEIDQKKDAENQEAQLKNGSLGSPGKQEAEEEEEEDDEKDKGKLKPNLGNGADLPSYRWTQTLSELDLAVPFCVNFRLKGKDVVVDIQRRHLRVGLKGQPAIVDGELYNEVKVEESSWLIEDGKVVTVHLEKINKMEWWSRLVSSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEILKKFMDQHPEMDFSKARFN
What is the function of this protein?
Plays a role in neurogenesis and neuronal migration.  Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity).  Necessary for cytokinesis and cell proliferation (By similarity).
What are the official names of this protein?
Nuclear migration protein nudC, Nuclear distribution protein C homolog.
What is the protein family that this protein belongs to?
Belongs to the nudC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=A small proportion is nuclear, in a punctate pattern (By similarity). In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells (By similarity). Localizes to the mitotic spindle in a EML4-dependent manner (By similarity).
Protein: RL30_GEOSM
Sequence: MSAELKITLVRSAIGQSEKMKGRLLGMGLTKREKTVTLQDTPEIRGMIAKVAHLVRVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: CLK3_RAT
Sequence: MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR
What is the function of this protein?
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.  Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex.  May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution.  Phosphorylates SRSF1 and SRSF3.  Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity).
What are the official names of this protein?
Dual specificity protein kinase CLK3, CDC-like kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome.
Protein: RL5_STRPS
Sequence: MANRLKEKYLNEVVPALTEQFNYSSVMAVPKVDKIVLNMGVGEAVSNAKSLEKAAEELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLDKLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEINFDDVDKTRGLDIVIVTTANTDEESRALLTGLGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: PROA1_SYNY3
Sequence: MVISPSLSALHTLAHNARQAALHLGSLNTAERNQAIAAIADGLTAAMPEILAANQEDCAAAEAMGIAKPLYNRLLLGESKLKSTIAGVKDVEHLPDPLGQVTLHRQLDEGLVLKRVGCPLGVLGVIFEARPEALIQISSLAIKSGNAVILKGGREATRSCQVLTEVIQTALAKTVVSPEAINLLTTREEIRELLGLNQYVDLIIPRGSNEFVQYIQQNTQIPVLGHADGICHLYLDAQADLSKAIPITVDAKTQYPAACNAIETLLVHQAIAAEFLPPLAQALGEKGVSLRGDSGTQKLIDCEPATEADWCTEYSDLILSIKIVDSLEAAIDHINQYGSKHTDGIISEDLTAAEQFCQRVDSAGVYHNCSTRFADGFRYGFGAEVGISTQKMPPRGPVGLEGLVTYKYQLWGHGHIAATYTGQGAKAFTHLDL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase 1, GPR 1, Glutamate-5-semialdehyde dehydrogenase 1, Glutamyl-gamma-semialdehyde dehydrogenase 1, GSA dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNA_BLAGS
Sequence: MTLAAITYTRGSLSILNQLLLPHQTTYDPLHSACDAWHAIHEMRVRGAPAIAIVAALSLAVELDALAANNQLSPEPKEVEVFIREKLEYLVSSRPTAVNLAEAAGRLGGIVSAKAEVRGVDGREVAEAYIAAAQRMLEDDVKDNRAIGEFGARWVLENAVATGSESGSEKGKVAVLTHCNTGSLATAGYGTALGVIRSLHATGSLERAYCTETRPYNQGSRLTAYELVHDKIPATLITDNMAAALLARNRAGSAASVGVSAIIVGADRVAANGDTANKIGTYGLAVLAKYHGVKFLVAAPRTTIDMNTKTGADIVIEERPKQEVTRVRGPRAGEEVDGLRAMETITVAANGIDVWNPAFDVTPAALIDGIITEVGVVEKDASGAFHLARIFE
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YCIB_SHEDO
Sequence: MKQLLDFLPLIIFFTVYKLVDIYTATGALIAATAVQIAILYFVYKKVEKMHLVTFAMVTVFGTLTLAFHDDAFIKWKVTIIYSLFAIALAVSQIMNKSIIKAMLGKELKADDNIWARVTWYWALFFIGCGVLNVYVAFSLPLETWVNFKVFGLTALTLLNTVISVFYIYKHAQPEQDDTAN
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAPSD_HBVD2
Sequence: MDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGDLITLSTWVGGNLEDPTSRDLVVSYVNTNMGLKFRQLLWFHISCLTFGRETVIEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRTQSRESQC
What is the function of this protein?
Self assembles to form an icosahedral capsid.  Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins.  Entering capsids are transported along microtubules to the nucleus.  Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta.  Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153.  Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm.  Immature capsids get stuck in the basket.  Capsids encapsulate the pre-genomic RNA and the P protein.  Pre-genomic RNA is reverse-transcribed into DNA while the capsid is still in the cytoplasm.  The capsid can then either be directed to the nucleus, providing more genomes for transcription, or bud through the endoplasmic reticulum to provide new virions.
What are the official names of this protein?
Capsid protein, Core antigen, Core protein, HBcAg, p21.5.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus core antigen family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: MPTA_NATPD
Sequence: MSQQLPDVQASSPDVSVGLSRVGVTGVEKLVKLHRPNDRPIVLMAEFDVFVDLPSWRKGADMSRNMEVVDEMLEEAVSEPALSVEDVCGDVAERLIEKHDYTTQAEVRMEAEYMIREETPATDRPTQATADIIASATADEDGNTREEIGCHVVGMTVCPCSQGMSESRARDVLEGLDVDRDTIDAFLEEVPQPGHSQRGHATLTVETSGDPDVDLRTLIDIARDSMSARIYNLAKRPDEDHMTFESHSDAKFVEDCVRSMANGLLEEYPDLPDDTIVRMEQSNDESIHQHNAHAERVAEFGQLRREVRD
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: DF257_ARATH
Sequence: MMNVSLKLSFLVFILVIMSNLGSEARELAGVNEIFEIAARSSNNAGTARALQQAPPCKRDVDCSFECPKGGFCNDRLGTCDCF
What are the official names of this protein?
Putative defensin-like protein 257.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBT_STAPU
Sequence: MEALVYTFLLVGTLGIIFFAIFFREPPKVPVKGKK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ISPD_CORDI
Sequence: MSRRVVALVAAAGKGTRLGADLPKAYVPLRDIPLVVRSVRAMITSAVVDEVIVIISPQMQDYAAALLLRWGLFSADIPVRLVHGGAERADSVWCGLQAIADTDAVVLIHDSARALTPPGMIARVARAVLDGNKAVIPVVPVADTIKTVHGTTVVATPPRRDLRAVQTPQGFDIAALRAANIAYQQQQPDFEATDDASLMEWFGTPVLCVDGDPMAFKVTTPLDYALAKAVTDQAEPTIFEVPSD
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: ZN408_HUMAN
Sequence: MEEAEELLLEGKKALQLAREPRLGLDLGWNPSGEGCTQGLKDVPPEPTRDILALKSLPRGLALGPSLAKEQRLGVWCVGDPLQPGLLWGPLEEESASKEKGEGVKPRQEENLSLGPWGDVCACEQSSGWTSLVQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLWPQPSSEGPSLTQPGLDKEAAVAVVTEVESAVQQEVASPGEDAAEPCIDPGSQSPSGIQAENMVSPGLKFPTQDRISKDSQPLGPLLQDGDVDEECPAQAQMPPELQSNSATQQDPDGSGASFSSSARGTQPHGYLAKKLHSPSDQCPPRAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGRRYRCGECGKAFLQLCHLKKHAFVHTGHKPFLCTECGKSYSSEESFKAHMLGHRGVRPFPCPQCDKAYGTQRDLKEHQVVHSGARPFACDQCGKAFARRPSLRLHRKTHQVPAAPAPCPCPVCGRPLANQGSLRNHMRLHTGEKPFLCPHCGRAFRQRGNLRGHLRLHTGERPYRCPHCADAFPQLPELRRHLISHTGEAHLCPVCGKALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKSHLEDKPYRCPTCGMGYTLPQSLRRHQLSHRPEAPCSPPSVPSAASEPTVVLLQAEPQLLDTHREEEVSPARDVVEVTISESQEKCFVVPEEPDAAPSLVLIHKDMGLGAWAEVVEVEMGT
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 408, PR domain zinc finger protein 17.
What are the subcellular locations of this protein?
Nucleus.
Protein: DDL_ACISJ
Sequence: MSQNDLKIDVKALGKVAVLMGGTSAEREVSLMSGGGVLQALRSRGVDAHAFDPAHSDLSELKAHGYSRCFIALHGRHGEDGTVQGALELLGIPYTGPGVMASSIAMDKIMTKRIWRADGLPTPDWRLVSSSAETAQAFQELGAPMIVKPSREGSTIGLTKVTSLGQCEQAYRLAAQHDPEVLCEQFIDGDETTCPILGQGTEARALPVIRIEAPQGNYDYQNKYFTDVTQYHCPSGLPEAEEREIQRIVVQAYRTLGCRGWARADIMIRASDRKPFLLEINTSPGMTGHSLVPMSANASGISYPDLCLRILASASLDALQGRAGAAGGRESV
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN125_MOUSE
Sequence: MGSLLSSDSSKSAPASATPRTLERSGDSELPITSFDCSVCLEVLHQPVRTRCGHVFCRSCIATSIKNNNKWTCPYCRAYLPSEGVPATDIAKRMKSEYQNCAECGTLVCLSDMRAHIRTCEKYIDKYGPLLELGDTTARCVCPFCQRELDEDCLLDHCIIHHRSERRPVFCPLCHSRPDESPSTFNGSLIRHLQVSHTLFYDDFIDFDIIEEAIIRRVLDRSLLEYVNQSNTT
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53.  Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation.  Mediates ubiquitination and subsequent degradation of p53/TP53.  Mediates ubiquitination and subsequent degradation of JAK1.  Acts as a positive regulator of T-cell activation.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF125, RING finger protein 125.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Note=Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane.