PharMolix/UniProtQA huggingface dataset:
Protein: METXS_NITEU
Sequence: MSTQDSDSIGIVSARRAHFDTPLSLKSGAVLDSYELVYETYGELNADRSNAVLICHALSGNHHVAGVYADNPKNTGWWNNMIGPGKPVDTRKFFVIGINNLGGCHGSTGPISINDKTGKRFGPDFPLVTTADWAKTYVRFADQFSIDCFAAVIGGSLGGMSAMQLALDAPERVRHAIVVAASARLTAQNIAFNDVARQAILTDPDFHDGDYYSHGTHPRRGLRLARMLGHITYLSDDSMASKFGRELRNGSLAFNYDVEFQIESYLHHQGDKFADLFDANTYLLMTKALDYFDPAQDYDGNLSAAFARAQADFLVLSFTSDWRFSPERSRDIVKALLDNKLNVSYAEIPSSYGHDSFLMQDDYYHQLIRAYMNNIAL
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_SHESW
Sequence: MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVAAKMLHLTKEQAEGFYAEHSERGFFGALVAFMTSGPIMVQVLEGENAVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSDAVESAAREIAYFFSAEELCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WHIA_STRT2
Sequence: MSFTIKVKEEIIAASSKDIAELSALIKMSGSVGLTNQGLTLSISTENAKIARHIYQLIENRYRCNPELRHYNKTNLKKNRVYTVFVAENVNDILSDLQLADSFFGFETGIETSIMEDDDAGRSYLRGAFLATGTVRDPEKGRYQLEIFSVYQDHAEDLASLMKKFMLDAKVLQHKNGFVTYLQKAEDIMDFLIVIGAMTSKEIFEEVKIMRETRNDLNRANNAETANIARTISASMKTINNIIKIMDTVGLEILPVELRQIAQLRIANPDYSIQQIADSIEPPLTKSGVNHRLRKINKIADDL
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: THIE_MYCGI
Sequence: MWSRSSLRRLTATVSTVPESPSLQGARLYLCTDARRERGDLADFADAALAGGVDIIQLRDKGSPGEKAFGPLEARAEIDALHVLAEAARRHNALVAVNDRADIARASGAEVLHLGQDDLPLTVARQIVGDRVIGRSTHDLAQAEAAIAEDVDYFCVGPCWPTPTKPGRAAPGLDLVREVAALNTTKPWFAIGGIDAQRLPDVLDAGARRVVVVRAITAAEDPRAAAEQLAGMLDSAV
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: EIF3J_ASHGO
Sequence: MSWDDEEFEVRTSTKDQPMVVSWDDEFNNDDDDALLESWDAEEVPKQKQKPKAAPKAAKKVDKKGETVLLEIDTLDEKTRKELLKKAELNSDLNNAAALFDGLGVAEEHPRARALRQEEELAALSRPAALTKQTPFESHPLFSEAETKSDFQDLRKALSTAIAGMAEKSSLNYSGALAIDLIRDVAKPLSIESIRQTVATLNVLIKEKERQERQARLAKVKGGTATGGAGKKKAKAARPNLGGAFKKDQEFSLEDNSEFADFGDDDFM
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit J, eIF3j, Eukaryotic translation initiation factor 3 30 kDa subunit, eIF-3 30 kDa.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit J family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXB_SALDC
Sequence: MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPINFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKDGPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDLNVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQHVALETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDETAAALLCKLGFNAVHHPAH
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: I23O1_HUMAN
Sequence: MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
What is the function of this protein?
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174).  Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885).  Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885).  Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885).  Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885).  Protects the fetus from maternal immune rejection (PubMed:25691885).
What are the official names of this protein?
Indoleamine 2,3-dioxygenase 1, IDO-1, Indoleamine-pyrrole 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the indoleamine 2,3-dioxygenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ATG4D_CANLF
Sequence: MNSVSPAAAQYRSGSPEDARRPEGRRPRGPRVPDPNGPRPSGASGPALGSPAAAPGEPDEVDKFKAKFLTAWNNVKYGWAVKSRTSFSKISSVHLCGRRYRFEGEGDIQRFQRDFVSRLWLTYRRDFPPLAGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWTWAEGPGLGPSEPAGLASPNRYRGPARWMPPRWAQGTPELEQERRHRQIVSWFADHPQAPFGLHRLVELGQSSGKKAGDWYGPSLVAHILRKAVESCSEITRLVVYVSQDCTVYKADVARLVARPDPTAEWKSVVILVPVRLGGETLNPVYVPCVKELLRSELCLGIMGGKPRHSLYFIGYQDDFLLYLDPHYCQPTVDVSQADFPLESFHCTSPRKMAFAKMDPSCTVGFYAGDQKEFETLCSELTRVLSSSSATERYPMFTLAEGHAQDHSLDDLCSQLSQPTLRLPRTGRLLKAKRPSSEDFVFL
What is the function of this protein?
Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis.  The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
What are the official names of this protein?
Cysteine protease ATG4D, Autophagy-related protein 4 homolog D.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
[Cysteine protease ATG4D]: Cytoplasm. SUBCELLULAR LOCATION: [Cysteine protease ATG4D, mitochondrial]: Cytoplasm. Mitochondrion matrix. Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death.
Protein: URE1_PHOLL
Sequence: MPTISRQEYVGLFGPTTGDKIRLGDTNLFIEIEKDLRGYGDESVYGGGKSLRDGMGADNRMTSENILDLVITSVTILDARQGVIKADVGIKGGRIVGIGKSGNPNMMNGVTPGMVVGVSTDAISGEHLILTAAGIDTHIHFISPQQVEHALSNGVTTFFGGGVGPTDGTNGTTVTAGPWHIHRMLRAFESLPVNVGILGKGHAAVAMPLVEQIKAGVAGLKVHEDWGATNSALRNALRVADEMDIQVAVHTDSLNEGGYVEDTIDAFEGRTIHTFHTEGAGGGHAPDIIKVASQMNVLPSSTNPTLPYGINSQAELFDMIMVCHNLNPKVPADVAFSESRVRPETIAAENVLHDMGVLSMFSSDSQAMGRVGENWLRVMQTAHAMKAARGKLPEDAAHNDNFRVLRYVAKITINPAIAQGISHVLGSVEVGKMADLVLWEPRFFGVKPKLVIKGGMINWAVMGDPNASLPTPQPTFYRPMFGALGKTLQETCVTFVSQAAMELGVKESLGLERQVMAVHNCRAISKKDMVRNAETPTIEVDAETFAVRVNGEYATVKPVRTVALNQRYFFS
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMD2_DROME
Sequence: MALVKPKSELTPEELARQEEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTELPRTGKGKKKVKPVNKDRFISKMFLRGDSVILVLRNPLATAAGK
What is the function of this protein?
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
What are the official names of this protein?
Probable small nuclear ribonucleoprotein Sm D2, Sm-D2, snRNP core protein D2.
What is the protein family that this protein belongs to?
Belongs to the snRNP core protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: NCAP_SV41
Sequence: MSSVLKTFERFTIQQELQDHEEDTPVPLETIRPLIRVFVVNSNDPALRAQLLLFNLRIIMSNTARESHKTGALLSMFSLPAAAMGNHLKLATRSPEASIDRVEITGFEGRSFRVVPDARSTMSRAEVLAYEAIAEDIPDTLNHKTPFVNADVEQGDYDETEGFLELCYSVLMQAWIVTCKCMTAPDQPPISIEKRMAKYQQQGRINPRFILQPEARRIIQNAIRKAMVVRHFLTYELQMAQSKTLLANRYYAMVGDVGKYIEHSGMGGFFCTLKYGLGTRWPTLALAAFSGELQKLKALMLHYQSLGPMAKYMALLESPKLMDFAPAEYPLMYSYAMGIGTVIDTNMRNYAYGRSYLNPQYFQLGVETARKQQGAVDHRTAEDLGMSQADKVELAATLAKLTIGQGGRGRQPLDDPFAGAAGDYQGAAAGGAQGFDYASRRVRKYNDYESDEEAGMDDDYEQEAREGRGYDDDDARQGIGGQSGFDFSVPQRAPGMSDEEFQAQMTKYIQHVQQHYQEAQEGAEDGGYNQTTDDQGAGGDFDT
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  The nucleocapsid (NC) has a helical structure.  The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication.  During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NP, Protein N.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses nucleocapsid family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: Y1647_SYNY3
Sequence: MEHALIELDWADIGWMLGLLGAAIALLQWQGLNLTGQLLWAGGRTILQLIVVGYFLAVVFSLDNPWAVLLVLAIMLTIAAVVARNRINPRSKSLFGWLWLSLGASTAISLGYALVVIIQPPQWYSPQYLIPLTGMILGQTMNSASLAGERLASAIQQNPREIETHLCLGATPGQAIASYRRAAIRASLIPTVNQMMVVGLVSLPGMLTGQVLAGGDPLNASVYQILIMFLILLTNTLSTIAVTATVYRQYFNQHQQLLV
What are the official names of this protein?
UPF0014 membrane protein slr1647.
What is the protein family that this protein belongs to?
Belongs to the UPF0014 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL22_WOLPM
Sequence: MKNRDVIVKAGSRVLKSTPRKLNLVAGLVRNKKVSFATVQLRFCEKKAAGLIRKVLNSAIANAQNYGLDIDNLYIKEILIGKSLTLRRVCPKAMGRANRVSKRYSNITVKLGEII
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: FABZ_FUSNN
Sequence: MLDILEIMKRIPHRYPFLLVDRILEMDKEAQIIKGKKNVTMNEEFFNGHFPGHPIMPGVLIIEGMAQCLGVMVMENFPGKVPYFAAIENAKFKNPVKPGDTLIYDVKVDKVKRNFVKATGKTYVDDAVVAEASFTFVIADM
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM205_XENTR
Sequence: MVAEGDPGNLVRTIHLLVLSASWGMQCWTTFVAGFVLIRGVPRHTFGLVQSKLFPFYNHIVLCCSFISLAIYAAYHPRELLSPSESVQITLFFVCLLAAALHARWFSPVTTKTMFKMHIIEREHSLGQGVGLSANREAYQRLQEKDPKYKALRQRFMRYHGISSLCNLLCLLCNGANLVYMALLMPTL
What are the official names of this protein?
Transmembrane protein 205.
What is the protein family that this protein belongs to?
Belongs to the TMEM205 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NTAQ1_ANOGA
Sequence: MSTNDANFMLFSNINDCSYVSCYCEENVWKLCEQVKKTYPSELPKCYAVFVSNERRTVPLWRQKAGRGDEKLVIWDYHVFFMHNPSPNRCLVFDLDTTLPFPTYFHKYVTETFRSDYALTPEHHRFFRVIPAEKYLAEFSSDRRHMRRPDGSWIKPPPSYPPIQTSASTHSLDDFICMKPGKGPGAVYDLLHFVQQFYKPPDRNIGTKTQN
What is the function of this protein?
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation.  Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.  Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
What are the official names of this protein?
Protein N-terminal glutamine amidohydrolase, Protein NH2-terminal glutamine deamidase, N-terminal Gln amidase, Nt(Q)-amidase, Protein tungus.
What is the protein family that this protein belongs to?
Belongs to the NTAQ1 family.
Protein: GLPB_SHIDS
Sequence: MRFDTVIMGGGLAGLLCGLQLQKHGLRSAIVTRGQSALHFSSGSLDLLSHLPDGQAVTDIHSGLESLRQQAPAHPYSLLGPQRVLDLACQAQALIAKSGAQLQGSVELPHQRITPLGTLRSTWLSSPEVPVWPLPAKKICVVGISGLMDFQAHLAAASLRELDLAVETAEIELPELDVLRNNATEFRAVNIARFLDNEENWPLLLDALIPVANTCEMILIPACFGLADDKLWRWLNEKLPCSLMLLPTLPPSVLSIRLQNQLQRQFVRQGGVWMPGDEVKKVTCKNGVVNEIWTRNHADIPLRPRFAVLASGSFFSGGLVAERNGIREPILGLDVLQTATRGEWYKEDFFAPQPWQQFGVTTDQTLRPSQAGQTIENLFAIGSVLGGFDPIAQGCGGGVCAVSALHAAQQIAQRAGGQQ
What is the function of this protein?
Conversion of glycerol 3-phosphate to dihydroxyacetone.  Uses fumarate or nitrate as electron acceptor.
What are the official names of this protein?
Anaerobic glycerol-3-phosphate dehydrogenase subunit B, Anaerobic G-3-P dehydrogenase subunit B, Anaerobic G3Pdhase B.
What is the protein family that this protein belongs to?
Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
Protein: PYM_AEDAE
Sequence: MTTYATDSQGKFIPSTQRPDGTWRKPRRVRDGYVPQEEVPLYESKGKLFAQKPLLPPGMSPEMAQKSREKREREQRIKQQREADANRRPPQNPVPGLLILNGDSKINQPQQRAAKSAKPKKKAVELPDVLLEQKQKEEQKQVRQQQQQQKSQKDHKNTKPHHQERIEEVAKAMNGLQLTNNHVASASAADALQTDLSKKLRKLRKKIREIEIIEERLRSTDGGPRPDKDQIDKAKRKPEILKEIEELEKGIAK
What is the function of this protein?
Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation.
What are the official names of this protein?
Partner of Y14 and mago, Protein wibg homolog.
What is the protein family that this protein belongs to?
Belongs to the pym family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by emb/Crm1 (By similarity).
Protein: YQGF_PARMW
Sequence: MPRPCSVLSLDVGRKRIGLAGCDPLGITVTPIKALHRGRFDDDLPVLQQLCQDRRVQGLVVGLPLDAAGQPTAQADHCLRYGRRLAQALQLPLAWVNEHSSTWAAGERHGLKGDRSGRLDSAAAALLLDQWLREGPDLKPVQGLLGGAGAELVDGGS
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INT9_DROME
Sequence: MRLYCLSGDLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDPQMDGELKDCCGRVFVDSTPEFNLPMDKMLDFSEVDVILISNYLNMLALPYITENTGFKGKVYATEPTLQIGRFFLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLSKVTIMGYDEKLDILGAFIATPVSSGYCLGSSNWVLSTAHEKICYVSGSSTLTTHPRPINQSALKHADVLIMTGLTQAPTVNPDTKLGELCMNVALTIRNNGSALIPCYPSGVVYDLFECLTQNLENAGLNNVPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKHYNHVFSEGFSKDFRQPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIFTEPDFPYLQVLAPFQPLAMKAFYCPIDTSLNYQQANKLIKELKPNVLVIPEAYTKPHPSAPNLFIEQPDKKIITFKCGEIIRLPLKRKLDRIYITSELAQKISPKEVAAGVTFSTLTGVLQVKDKVHCIQPCADSVKDETISSNSAPTKEDVLKNVKYEYGSIDVDAVMKKLAQDGFSNIKLDRTGGALTLNLVNEDTVIKFEDNETHIICGGKPTTRLKLRDTIMKCLQSF
What is the function of this protein?
Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424).  Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424).  May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
What are the official names of this protein?
Integrator complex subunit 9.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: IOD3_SPAAU
Sequence: MHDSGGVQMARALKHAALCLMLLPRFLLAAVMLWLLDFLCIRKKVLLKMGERQDGPDDPPVCVSDSNKMFTLESLRAVWYGQKLDFLKSAHLGRTAPNTEVMLVQERRQVRILDCMKGKRPLILNFGSCSUPPFMTRLAAFQRVVSQYADIADFLVVYIEEAHPSDGWVSSDAPYQIPKHRCLEDRLRAAQLMLAEVPGSNVVVDNMDNSSNAAYGAYFERLYIVRDERVVYQGGRGPEGYRISELRNWLEQYRNGLVNSQTAVLHV
What is the function of this protein?
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine).
What are the official names of this protein?
Thyroxine 5-deiodinase, 5DIII, DIOIII, Type 3 DI, Type III iodothyronine deiodinase.
What is the protein family that this protein belongs to?
Belongs to the iodothyronine deiodinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Protein: NECA2_HUMAN
Sequence: MCERAARLCRAGAHRLLREPPQQGRALGGLLRWVGARMGEPRESLAPAAPADPGPASPRGGTAVILDIFRRADKNDDGKLSLEEFQLFFADGVLNEKELEDLFHTIDSDNTNHVDTKELCDYFVDHMGDYEDVLASLETLNHSVLKAMGYTKKVYEGGSNVDQFVTRFLLKETANQIQSLLSSVESAVEAIEEQTSQLRQNHIKPSHSAAQTWCGSPTPASAPNHKLMAMEQGKTLPSATEDAKEEGLEAQISRLAELIGRLESKALWFDLQQRLSDEDGTNMHLQLVRQEMAVCPEQLSEFLDSLRQYLRGTTGVRNCFHITAVRLSDGFTFVIYEFWETEEAWKRHLQSPLCKAFRHVKVDTLSQPEALSRILVPAAWCTVGRD
What is the function of this protein?
May act as a signaling scaffold protein that senses intracellular calcium.  Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
What are the official names of this protein?
N-terminal EF-hand calcium-binding protein 2, EF-hand calcium-binding protein 2, Neuronal calcium-binding protein 2, Synaptotagmin-interacting protein 2, Stip-2.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, dendrite. Cell projection, axon. Cell membrane. Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity).
Protein: GDIA_HUMAN
Sequence: MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRIICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ
What is the function of this protein?
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.  Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation.  Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
What are the official names of this protein?
Rab GDP dissociation inhibitor alpha, Rab GDI alpha, Guanosine diphosphate dissociation inhibitor 1, GDI-1, Oligophrenin-2, Protein XAP-4.
What is the protein family that this protein belongs to?
Belongs to the Rab GDI family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus, trans-Golgi network.
Protein: PTH_LACH4
Sequence: MKIIAGLGNPGQKYDKTKHNTGFMTLDHYLNEKGLSLDKDKFEGHWTKQKINGEDVILLEPQTYMNESGRSVSQIANFFKVAPEDVLIIQDDMDMPIGKIRIRANGKSGGHNGIKSIIRDLGTEKFNRLKIGIRHPKNTTVVSWVLTPFNDEQQKLMDDAFDTSVKIIDDFIAGRDSQYLMNKYN
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_SYNSC
Sequence: MAGGVTGGAAGTWSDRFEQGLHPFIEAFNASIGFDLTLLQEDLDGSIAHARMLASVGVITEAEAEQLVEGLETVRAEAASGSFQPGLADEDVHFAVERRLIALLGPVGKKLHTGRSRNDQVGTDLRLWLRRRLDGLDQDLQRLQGALLTQADRHRRTMIPGYTHLQRAQPLCLAHHLLAYVEMLERDRERLQDARKRVNICPLGAAALAGTPVPIDRQRTAKELGFSAVYANSLDAVSDRDFCVEFSAAASLVMVHLSRLAEEVIAWASEEFGFVRLSDRCATGSSLMPQKKNPDVPELVRGKTGRVFGHLQGLLTMIKGLPLAYNKDFQEDKEALFDAFRTTRDCVEAMAILFEEGLDFRVERLNEAVEQDFSNATDVADYLVSRGVPFREAYQLVGAVVRRCLEQGCLLRDLDLSAWKELHPAFEADLHDALAPRAVVAARRSEGGTGFERVDEQLQRWLQRFNGTQPVG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_DESRM
Sequence: MLVLVVNCGSSSIKYKLMDMEQESVLLSGLSERIGIAGSRIKQENNKGEELVLEQDLPDHKAALETILKCITDAKYGAIKDTAEIKAVGHRVVHGGEKFNKSVVIDAELMKVLEEMSELAPLHNPPNIIGIKTCQELMPHAAQVAVFDTAFHSAMPKHAYTYAVPYEYYEKYKIRRYGFHGTSHKFVSHRAAEILGKPVEDLKIIVCHLGNGSSISAVGNGVSQDTSMGFTPLPGLPMGTRTGDMDPAIVPFLMEKEQLGVNEIGNVLNKKSGVLGVSGISSDFRDLEDAASKGNERAELALNMFAYGIIKYIGAYTAALGGLDAVVFTGGIGENSKTMRAKVLNGLAYTGLQIDEEKNNTRGKEVIVSKPGAPFVAMVVPTNEELMIARETKELV
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.