Protein: BA17A_METAN
Sequence: MLQKSYHGVVSQASYDNTCGRGSQIRRDRSRAGVRFNTEYNPVLLTVSKQIAQDGEGYHCRANLINKITTKQQLAFISELQPTQSTLKVLPVADGRKMPIEPIAIVGASCRLPGSSNSLDSLWELLADGGEAWSSVPADRFNEAAFHHPNASDPNGTNNHQGGHFIDGDIRDFDHAFFHLSPQHAAAMDPQQRILLELVYEAFESAGWAREACAGSRTAVFAAIFGTDYDRNLCKDLLDLPVYHSVGTGIAILANRISHAFDLRGPSLTLDTGCSGGLVALHEACQSLRNGESDAALVAAANLQLMPDHYIGMSSQHMVSSTGRCYPFDLRGDGYGRGEGFAVVALKRLSDALRDQDPIRSVILNSGINQDGYTASGITHPNRVAQADLIRDTYDRVHLHPQDTVYVEAHGTGTVAGDNEELAAIAEVFAGPDRSLPLHVGSNKGSIGHTESTSGLASLLKVILMLDHQVIPPVAGFTNPKPGLPLDRIKIPTQRLPWPLTEGMVPRISINSFGYGGTNAHAIMERGPRTYDASCNTTPTYSPRLFVLSANNKGSLRSLLESYVNWIQKHPNIPLADISYTLCHRRSALPWRFSCVADSESSLLDTLERGVKLISTRPPPSKRQVIYVFTGQGAQWAGMGHELLLETTPSSVFRDSIRTSRDILYELGATWDLEAELLGQDGGGRINKAELAQPATTAVQIGIVMLLRSQGVRPWAVVGHSSGEIAAAYAAGRLSHRMALRVAFHRGFMAGVSKDRGLPPGAMLSIGLGQGDAAPYLHDLTHGEAVIACINSPNSVTVSGDAAAVDEVMARIIARGDGTFCRKLHVDTAYHSHHMRAVADEYCIRLGDLDLGIDERISAPGGQRDKEEVKYFSSNSGLAWVSGFAASYWVDNLISPVRFSDAIQTVAREHHKHNGGLALFVEIGPHAALAGPIRQCLAASNVPKLEYNYLSALKRGAGAVETMLQVVGHLFERGVRVNFDEISALTPGFHTAAVRPDLPSYCWDYSSKHWHESRLSREYRMRREPYHHLLGVRMTELASTEPRWRHMVGLATLPWLAHHIIDGLIIFPGACYVCMVIEAVRQLAKEQYSDQALEAVSLRDVSFLRALVVPDAPSRVEMQLSLKHRADASPLGFTFSVTALSDGKWHVFCTGVVEGVMTLDKPETEPVMLDPRPKQDWLNRTMVIPEELYNEMTADGNTYGPSFRGLSSLTMSTDGSMATAVIEVPDIAASMPAQYQASHILHPTTLDSMFHVGIPMMKRRHGAGSVMPVHIGELLISTQTPALNSQGSKLDVSAKLTSSHFRASNIDMTIVSGGFPVMYASAIESRSLAAHVDGAHGTQDEHGICYELAWRCDLNFLRTSDLTRSSILADLVSFLCFKTAHLSIAELGESPGVLAPAFLAAVGVHRGTVTSYDVVERGNQPIDEGCKRLTGYPIRRRALDPDSSLESQGFAPNTYDVVLASDLGSLCYVSTLVKNDGVVVVVLKPGSDDNWQSTLRKTWPSHDIQLTVVDSVNGNRIILARNDKTKDSHSSSRVHILTHSALQTTPSWATALIGKLHEMGYEMSSGSLSQDVIQRSSDARNTCIMVIDDLAQPILSDRACFNSAITLLRQEHRIIWLSLDSPSSMHQITGVARTAHAENDNLRLTVVHAALEAIGSPPLVDLLCHCLTYAQNRDSLAPYEREYRVSRDAAVLIPRLRSSDCLNRAIRASEKASEPSSNIETEPHHYINTTRSLALGPVQSSKGDGDIVFIDSHTVELAEGQVEVETEAFVLSKSQNLTSSQLGEYSGIVRRVGKGVRDFSPGDAVVALALDGVVGANHARVPSSHVSRRPDSLSPAVAAALFLPTIAASYAIHHLAQISKGKSIVLIHGVLTDIGRASVAVARVLGATITATAISRQEALEITQQLNIQLENIIVSRPSLLRPQLDELFQLDAIIHISKDSVPVAAWSCLKPFGQVVVFNSSSSIAFPSPPPENATIHYCHITNLVQAQPDRLADLVSLAAPALERIPFKGIDLCIQDVAQVPEAIRLVRQGGKVILQASPSSLVRTVIPSSISMDWEAVDAAYVVAGGMGDLGRRLLLLMARRGAMHLVTLSRRSIEPEDHRSFQGQLQLVQPGCRLYCLVCDITSESSVQNAADTLTRTGVPPVRGVIQSAVTLHDRTLETMTFDDFFAVAHAKVDGTLVLERVFASPHLHFFLMLSSAVNITGASGQANYNAGNAVQDAIAHDRGPGFLSMNIGWIEDAINTSNNKTILQGLWRTGLRPILGQELSRYFDHLLGAASSHSRMRQAIIGFNAASLSHTSASNSNVHSAMFCHIRGSLAAEESSSSTNNVRSFGEVVEGGDLDTIIDFISSAITRRLMTLISMDDDQIKDRNGSILDLGLDSLVAIELRNWITREFKSPLQSSEILTDQPIRDLAEKVASRSSLLASGLDKEVPAGSLENGDVEDRHSAGAIRPSTSAHSTVKYVSENLPPLPLPPLADTLRLFEDSRRAIDTANHRRNTSDAVHDFLKGPGPRLYNSLQETNSDVIADAYDRQVYLERREPLPEQGPFIFIHSIQAPVHSQARRAAILTIAAFDFIRLLARGDIATDTLHGEPITTEGRNWLFYATRRPGIGIDRMERHVPNNTVAVLRRGHVFQLRLPDVEQALDMLAVTRVYDDILAASCDAIPPICTLTADERDSWALFRLDLERHPQNAAVLACIDTAAFVMCLDDESPTSSGERYTQFMINGAHRPFANRWLDKTLQFAVTANGISAEIYEHSKLDGIDTNRLHAHIARAILAHPPSETADISSFSSPYAVQELMWEPSSATLQRIEHVRTQCQVYGPLDHQVFDVASLGLRSLRGFRLQPNATAHLTVLLALYLVDGEIRPAWEKVSLGTFARGRVEWVQTISPAARAFIEAAAASYTDSNNRTRVRALLHQATSTHSRSLVAAGRGLGAVRALYALRGAAQEQEKELPELFRTHSWDATRRGGPGQDVKLGFMRLAPDDDANGNVGATPGDDDINGRWDEAGFLVCGERGVYVHCNVWEKHARFAASGRPAYVTKLCKAMRRASCMITSLLEDPSKRPT
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of (2Z,4E,6E,10E)-9-hydroxydodeca-2,4,6,10-tetraenoic acid (BAA), (2E,4E,6E,10E)-9-hydroxydodeca-2,4,6,10-tetraenoic acid (BAB), and (2Z,4E,6E)-octa-2,4,6-trienedioic acid (PBA) (PubMed:33991663).  The highly reducing polyketide synthase Ba17a is sufficent to produce PBA and BAA (PubMed:33991663).  The still to be characterized protein Ba17b leads to an increased production of BAA as well as to the production of the new compound BAB (PubMed:33991663).  BAA does not possess insecticidal activity against G. mellonella larvae, however, both BAA and BAB increase the growth of Candida albicans and BAA can mitigate the fungicidal effects of fluconazole over C. albicans, suggesting that generalist pathogens such as M. anisopliae, can potentially manipulate the yeast microbiota found in arthropods (and anywhere else) by the activity of compounds as BAA and BAB (PubMed:33991663).
What are the official names of this protein?
Highly reducing polyketide synthase 17, HR-PKS 17, PKS17 biosynthesis gene cluster protein Ba17a, Polyenoic acids biosynthesis gene cluster protein Ba17a.