PharMolix/UniProtQA huggingface dataset:
Protein: CARA_MYXXA
Sequence: MTLRIRTIARMTGIREATLRAWERRYGFPRPLRSEGNNYRVYSREEVEAVRRVARLIQEEGLSVSEAIAQVKTEPPREQPEAERLRERFWSSVGALEGDEVTRVLDDAQTVMDVEAYCDGFLLPLLREMGVRLDVAREHLASALIRQRLRQVYDALSPAPAGPRALLACPSGDHHEGGLLVLGIHLKRKGWRVTMLGADTPAAALQGACVQVRPDVVALSFVRARAPEEFASVLEDALRACAPFPVVVGGLGAREHLKAIFSLGAQYAESSEELVAIWNQVRNAQNRP
What is the function of this protein?
Negative regulator of the carB operon in the dark.  Binds specifically to the CarA operator, in the region around the carB promoter, which blocks access to the RNA polymerase.
What are the official names of this protein?
HTH-type transcriptional repressor CarA.
What is the protein family that this protein belongs to?
Belongs to the CarA/CarH B12-binding photoregulator family.
Protein: RIMM_SHEAM
Sequence: MSSNQQPVVVGKIGSTYGVKGWMKITAYTDSVEGIFDYSPWFLKEHGEWREVKVSQWRFHGKAVVAELEGVSNREQAQMLTNCEIGILAEQMPELPEDEFYWRDLIGCEVLNTKGYNLGKVDQILETGSNDVLMVKANAKDAFGKTERMIPYLPDQFVLEVKLSEKQIIVDWDPDF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSM3_HUMAN
Sequence: MLARVTRKMLRHAKCFQRLAIFGSVRALHKDNRTATPQNFSNYESMKQDFKLGIPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWWINRNGEEMRWSFEELGSLSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCIITNDVLAPAVDAVASKCENLHSKLIVSENSREGWGNLKELMKHASDSHTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFWLDLTPSDVMWNTSDTGWAKSAWSSVFSPWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCSAPTVYRMLVQNDITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKIVDVNGNVLPPGQEGDIGIQVLPNRPFGLFTHYVDNPSKTASTLRGNFYITGDRGYMDKDGYFWFVARADDVILSSGYRIGPFEVENALNEHPSVAESAVVSSPDPIRGEVVKAFVVLNPDYKSHDQEQLIKEIQEHVKKTTAPYKYPRKVEFIQELPKTISGKTKRNELRKKEWKTI
What is the function of this protein?
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11772874).  Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (By similarity).
What are the official names of this protein?
Acyl-coenzyme A synthetase ACSM3, mitochondrial, Acyl-CoA synthetase medium-chain family member 3, Butyrate--CoA ligase 3, Butyryl-coenzyme A synthetase 3, Middle-chain acyl-CoA synthetase 3, Propionate--CoA ligase, Protein SA homolog.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: NADK_MYCTU
Sequence: MTAHRSVLLVVHTGRDEATETARRVEKVLGDNKIALRVLSAEAVDRGSLHLAPDDMRAMGVEIEVVDADQHAADGCELVLVLGGDGTFLRAAELARNASIPVLGVNLGRIGFLAEAEAEAIDAVLEHVVAQDYRVEDRLTLDVVVRQGGRIVNRGWALNEVSLEKGPRLGVLGVVVEIDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPEATIAIEIEADGHDALVFCDGRREMLIPAGSRLEVTRCVTSVKWARLDSAPFTDRLVRKFRLPVTGWRGK
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.  It can use ATP and other nucleoside triphosphates as well as inorganic polyphosphate (poly(P)) as a source of phosphorus.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase, Poly(P)-dependent NAD kinase, PPNK.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_THEP1
Sequence: MKIVVAKNIGFCFGVERAIRTVEELLDEGKKVVTDGEIVHNKQVMEKLTKKGLKVSSEITDGEVFVVRAHGIPKDRLEELKRIFPEVVDLTCPIVSQLFKTAQRYAKERKVIVFGKEDHPEMVALKGYAPAIVTKVPFKLEEKKVVFLSQTTSSLEEYKEFVVTMIRMNEFEEAVFLNTICPVTVNREREVEELSRICELSIVVGGRHSSNTGKLFRIASKHSKTIWIESPDELPADVVKYGTVCVFSGTSTPNSLIENVVRKLKEMEGKRDGTI
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: NRDR_CLOBK
Sequence: MKCPYCAYGESKVVDSRSTEDGSSIRRRRECLKCNRRYTTYEKIETTPILVIKKNMSREYFDRNKIVNGLMKACQKRPVSRKQIEQIANEVERHISNEMLTEVNTDKIGQIIMKNLKKIDEVSYVRFASVYRQFKDINTFMEEIKNLMDKN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: LEU1_GEOKA
Sequence: MRKIKFFDTTLRDGEQSAGVNLNLQEKLEIARQLERLRVDIIEAGFPASSKGDFEAVKQIAETVRTCSVTGLSRSVRSDIDAAWEALKGGAEPRLHLFIATSPIHMVHKLRMTPEQVIEAAVEAVKYAKRFFPIVQWSAEDACRSELPFLAKIVAEVIKAGASVINIPDTVGYITPKEYGEIFLYLQNNVPNIENVSLSAHCHDDLGMAVVNSLSAIEHGATQVECTINGIGERAGNAALEEIAVALHIRKDYYQVETRLNLQEIKRTSNLVSKLTGVVVPPNKAVVGKNAFAHESGIHQDGVLKEKTTYEIISPELVGVPSNSMVLGKHSGRHALRNRVEELGYTLSDEEINQLFVRFKELADKKKDITDDDLIALIFEEKFDHFKDFYQLSSIQVQYGTNQIPTAVVVLKDGKGNEIQEAATGAGSVEALYNTLERCFQTPVTLLDYRIESVGGGRDALAQVFVKVRAHDIETSGRGTAQDVLEASAKAYINAINRVFMIEAMRGENEKVATP
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: BRL05_BRELC
Sequence: MGPQHLLALVVVSILVAAGNAYYEIDDDSVTRALRPSVIADQEHAVHAIPATNFISKDEDHSKNEKKEIEIIRIAIFSLLVVGVFAIMALRCLPFCL
What is the function of this protein?
Secreted effector that inhibits stress-induced relocalization of the transcription factor NAC069 to the nucleus, thus affecting its broad role in abiotic and biotic stress responses.
What are the official names of this protein?
Secreted RxLR effector protein BLR05.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host endoplasmic reticulum membrane; Single- pass type I membrane protein.
Protein: ATPB_BDEBA
Sequence: MAFGKVKQVMGPVVDVEFEGGELPAINSALRVSNKFISDVEFNLVLEVAQHLGDGVVRTISMDQTEGLVRGEKVKALGTQITAPVGREALGRIINVVGEPIDEMGPVNAKEQWGIHRTAPKFEDQATAAAMLMTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIQELIRNIATEHGGFSVFAGVGERTREGNDLWQEMKQSGVLAKTSLVFGQMNEPPGARARVALTGLTVAEYFRDVENQDVLFFVDNIFRFTQAGAEVSALLGRIPSAVGYQPTLATEMGTLQERITSTKKGSITSVQAVYVPADDYTDPAPATTFTHLDATTNLDRDIAAMAIFPAVHPLTSTSRLLDPTVIGEEHYKCARDVQALLQRNRELQDIIAILGMDELSESDKLVVSRSRKIQRFLSQPFFVAEQFTGLPGKYVDIKDTVKGFREILDGKHDALPEQAFYLVGTIEDAIEKAKKLQA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ZCH10_HUMAN
Sequence: MATPMHRLIARRQAFDTELQPVKTFWILIQPSIVISEANKQHVRCQKCLEFGHWTYECTGKRKYLHRPSRTAELKKALKEKENRLLLQQSIGETNVERKAKKKRSKSVTSSSSSSSDSSASDSSSESEETSTSSSSEDSDTDESSSSSSSSASSTTSSSSSDSDSDSSSSSSSSTSTDSSSDDEPPKKKKKK
What are the official names of this protein?
Zinc finger CCHC domain-containing protein 10.
Protein: APOC3_MACFA
Sequence: MQPRVLLVAALLSLLASARASEAEDTSLLGFMQGYMQHATKTAKDALTSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKLSGFWDLNPEAKPTLAEAA
What is the function of this protein?
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma.  Plays a multifaceted role in triglyceride homeostasis.  Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs).  Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.  Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
What are the official names of this protein?
Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TMM98_HUMAN
Sequence: METVVIVAIGVLATIFLASFAALVLVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEGFLQEQSAI
What is the function of this protein?
Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination.  Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation.  The secreted form promotes differentiation of T helper 1 cells (Th1).
What are the official names of this protein?
Transmembrane protein 98, Protein TADA1.
What is the protein family that this protein belongs to?
Belongs to the TMEM98 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Secreted. Secreted, extracellular exosome. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Secreted by exosomes through a non- classical pathway.
Protein: UVRC_LEPBJ
Sequence: MPEILNHILILEKIKNLGISPGCYLWKSRKGEVLYIGKAKNLDKRVRNYLKENHPDIKTRALQKEIFDLDWIATGTEKEALILEATLIKKHNPRFNVRFKDDKKYPYICVSLSESFPMVYITRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQVLPLPKPRRPCLNFDMGRCLGPCQGNIPVEDYKIVIDQVIQFLEGKKESLVGDLSIKMSASSNRMDFEKAARYRDMLQRIQNFREKQTVVSAEGGDEDVIGFARKKDEGQVILLEVRGGRLETKKSFPIQGVLDAEDSEILGAFFRDYYLNAALVPPLIFVPADIQEETAAVMDVLQEKTGFRPKLKSPRGGDKRSLLKIAEKNAELGLTERLLATHYRDQTASLKEIQEMFSLEHPPHIIECYDISHFQGSEPVASGVMFVEGKPFKQGYRKYNIRGYKGINDPGMIHEVISRRLQRIANEESVFPDLIVIDGGPTQLAKACEAAMEAGAERIPMIGLAKKREEIYFPGDNEPFIFDMNSSGMKLLRHLRDEAHRFGVSHHRSRRNKETMRSLIQNVPDIGLKRSKLLLRHFSGEKKIEDATKEELLAVPGIGENLAEKILKRIRKKE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EVX2_HUMAN
Sequence: MMERIRKEMILMERGLHSPTAGKRFSNLSNSAGNAVLEALENSQHPARLSPRLPSAPLHSALGELPAKGKFEIDTLFNLQHTGSESTVSSEISSAAESRKKPGHYSEAAAEADMSSDVEVGCSALRSPGGLGAAQLKENNGKGYAESGSAAGTTTSASGSGLGSLHGGSGGSGGSAALGGSGSGADQVRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMSWPHPADPSFYTYMMTHAAATGSLPYPFHSHVPLHYYPHVGVTAAAAAAAASGAAAAASSPFATSIRPLDTFRALSHPYSRPELLCSFRHPGLYQAPAAAAGLNSAASAAAAAAAAAAAASSAAAAGAPPSGGSAPCSCLSCHSSQSAAAAAAAAAAALGSRGGGGGGGGGGGGGGGGAGAGGGSDFGCSAAAPRSESGFLPYSAAVLSKTAVSPPDQRDEAPLTR
What are the official names of this protein?
Homeobox even-skipped homolog protein 2, EVX-2.
What is the protein family that this protein belongs to?
Belongs to the even-skipped homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OTP_LYTVA
Sequence: MERTLAHVPSMELSTEALLVTGGLDNTNKMITSSAVRNDDGTMISQHSEKVSYGTSGAPDGSTPPVTAAGGGSEGNGIGGGGGGGGGMVGDGTGHSVGSSASGNDDDKPAKQKRHRTRFTPAQLNELERNFAKTHYPDIFMREEIAMRVGLTESRVQVWFQNRRAKWKKRKKTTNVFRTPGALLPSHGLAQFPSPMNDSFCNFHGQDTRGWPAMSGMTTHMAPHMTTHMPSHQMSQMGGGPGSALALPPSIPRQGLGQSMQQQTVNCTMGQSTGLNTLSMGTNGSMGSMTSMYQPSLGGMTTGSMSSGLSSPSPPNLPVSDSSTDLSCSVSDAGDMWRGTSIASLRRKALEHAASLNGNL
What are the official names of this protein?
Homeobox protein orthopedia.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIPT2_DROME
Sequence: MPFVRPLVTVVRAGRHSYSAGLQLQQRLARSNQILNPPAEFRNYLVLQEHDPVYTVGLRTKDYTAQDEDRLRRLGADFHRTDRGGLITFHGPGQLVAYPILHLGQFVPSIRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDNKICAIGIHGSRYVTTHGIGLNCCTDLQWFEHIVPCGIEGKGVTSLSKELDRHFPVEEASGALLNSFAKVFECRLQEHAKKPASSAEIG
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity).
What are the official names of this protein?
Putative lipoyltransferase 2, mitochondrial, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RBFA_LIMRD
Sequence: MPSKQYRVDRLAQEIQKDVDEILLKRVRDPRVQNVTITGVDVTGDLQQATIYYSILSDLASDAEKAQAGLDKATGLIRSELGARLNIFKTPEIKFVRDPSVAYGSRIDQLINDLHKKEK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_STRA1
Sequence: MIDRKDTNRFKLVSKYSPSGDQPQAIETLVDNIEGGEKAQILKGATGTGKTYTMSQVIAQVNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYADSVVSLRPGQEISRDQLLNNLVDIQFERNDIDFQRGKFRVRGDVVEVFPASRDEHAFRIEFFGDEIDRIREIESLTGRVLGEVEHLAIFPATHFMTNDEHMEEAISKIQAEMENQVELFEKEGKLIEAQRIRQRTEYDIEMLREMGYTNGVENYSRHMDGRSEGEPPFTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVHQIVYVSATPGDYEMGQTDTVVEQIIRPTGLLDPEVEVRPSMGQMDDLLGEINLRTEKGERTFITTLTKRMAEDLTDYLKEMGVKVKYMHSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSNGHVIMYADKITDSMQRAMDETARRRRLQMDYNEKHGIVPQTIKKEIRDLIAITKSNDSDKPEKVVDYSSLSKKERQAEIKALQKQMQEAAELLDFELAAQIRDVILKLKAID
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2555_FLAJ1
Sequence: MDLMGMMGKLKETQQKIEDTKKRLDTVLIDEQSADGLLKITVTANRKVKSISIDDSLLEDKEQLEDYLVVTLNKVIEKATSVNERELDAVARMDMPSIPGMDNLFK
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Fjoh_2555.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PTFA_HALVD
Sequence: MDVTDISTITPLELISLEEPPATKEGAIEFLLDLAVDAGRVDDRDAALDALLEREGEATTGVGFGIGIPHAKTDAVSKPTVAFARSAEGIDFDAMDDKPAKLLFMILVPAAGGEDHLQILSALSRSLMHEDVREKLLEAESKQTVQDVLAEVVE
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II PtfABC PTS system is involved in fructose transport.
What are the official names of this protein?
PTS system fructose-specific EIIA component, EIIA-Fru, Fructose-specific phosphotransferase enzyme IIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP1_ALBFT
Sequence: MTVSKSSLSALTLGAIGVVYGDIGTSVLYAVKEVFGSGHVPFTSDNVYGILSIFFWTLTIIVSLKYVTLVLRADNNGEGGLIAMLALASQSVKDKPALRRVLLLVGIFGTCLFYGDGVITPAISVLSAVEGLEVVSPAFNKFVIPLTLLVLFGLFWVQKRGTAGIGKFFGPITVVWFACIAVLGVAQIATHPTVLWAISPYHALSFIWRQPGTSFIILGAVVLCVTGAEALYADLGHFGKKPIRVAWFAVVMPALTLNYFGQGALLLNNPAAVKNPFFLMAPDWALLPLVGLATLATVIASQALISGAFSVTKQVILLGYLPRLKIMHTNVKEVGQIYLPFVNWGLFVTIVLAVMIFKSSSNLASAYGIAVCTDMLITTILTFFVIRYSWKYPLWLCVAATSFFFVVDFAFWASNLLKLFDGGWFPLLIGGAIFILMITWKDGRRLLNDKLRADAIDLNSFLEAVFVSPPVRVEGTAVFLTVEAGTVPNAMLHNLKHNKVLHANNLFVTVHNHEVPWIGMEKRLEIESLGHDCWQVIINYGFKNDPNIPKALQHIKGRGCDLNDMTTSYFLSRDTIVPTIGSGMAQWREKLFSQMHHNASGAADFLRLPNNAVVELGSKIEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 1.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: METN2_LISIN
Sequence: MITLQNVVKEYTSRNNKVLAVDHVDLEIEQGEIFGVVGYSGAGKSTLIRMFNGLELPTEGSVEVDNLLISQIRGSKLRKARQQIGMIFQHFNLLWSRTVAENIAFPLEIAGVRGEKRRFRVNELIRLVGLEGKENAYPAELSGGQKQRVGIARALANNPKVLLCDEATSALDPQTTDEVLELLLDINKRLNLTIIVITHEMHVIRKICNRVAVMENGKVAELGDVLDVFRHPKEKVTQRFVRQVTDSDETEELIHLLLDNYAEGKIVKLLFMSENATQPVISQVAKENDVMLNVLHGNLTQTQNGAYGTLYVQVLGTEEAIEASLTQLRQLKVETEVLER
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: APRA_DICDI
Sequence: MSKLLILLLLSLVASIFSTPLDDYVNAPDDTYKWTLNNTIEYETFTGYILELTSQTWMAEKSDWPVWKHWVSICVPKGVTTTTTFIYVDGGSNDNWKVPGSMDQTIEIVCLSSGSVSVGLTQIPNQPIIFNNDGVQRFEDDLVAYTWRQFLGNTSEPLWLARLPMTKAVVKCMDAVQEFGKTIGYNSENFVIAGASKRGWTTWLAGVVDPRIIAIVPIVMPILNMIPNMGHQFYAYGEWSFALNDYTGQGVMDYLNGPQMVELAAIVDPFSYRDRYTMPIYAIASSDDEFFLPDSPQFFWNNLTATPEKHLRIVPNAEHSLMGHQIDIILSIVTFVRLLITNQPRPTFTWDITYSEDLNSGTIVLTVPEGGIIPYKVKVWTAVTESTTRRDFRIITCMDITKCIQFIIWDPSDITPTSTGVYSITLSKPDAGWRAFFLEAEYLYAKNSIDDEYTLKFTSEVAIVPNTLPFGSCSEYNACGDGSQGDSASSTATL
What is the function of this protein?
Inhibitor that slows proliferation of secreting cells (also known as chalone).  May function by binding to cell surface receptors.  Requires cfaD for activity.  Overexpression slows proliferation.
What are the official names of this protein?
Autocrine proliferation repressor protein A, PhoPQ-activated pathogenicity-related protein.
What is the protein family that this protein belongs to?
Belongs to the pqaA family.
Protein: RS3_PONAB
Sequence: MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEEVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPVPTA
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Has endonuclease activity and plays a role in repair of damaged DNA.  Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA.  Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS).  Has also been shown to bind with similar affinity to intact and damaged DNA.  Stimulates the N-glycosylase activity of the base excision protein OGG1.  Enhances the uracil excision activity of UNG1.  Also stimulates the cleavage of the phosphodiester backbone by APEX1.  When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage.  Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide.  Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes.  Represses its own translation by binding to its cognate mRNA.  Binds to and protects TP53/p53 from MDM2-mediated ubiquitination.  Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization.  Involved in induction of apoptosis through its role in activation of CASP8.  Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5.  Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation.
What are the official names of this protein?
40S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Mitochondrion inner membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, spindle. Note=In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis. Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide. Accumulates in the mitochondrion in response to increased ROS levels. Localizes to the spindle during mitosis. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: APT_ASHGO
Sequence: MSINEYAKELKAALAQYPNFPKEGVLFEDFLPIFRSPQLFQKLIDAFKMHLAEAFPETKIDYLVGLESRGFLFGPSLALAIGAGFVPVRKAGKLPGQVVKTTYVKEYEEDVFEMQVDSIPVGATVVVVDDILATGGSAGAAGDLIKQLGATILEFIFVMELDFLKGREKLQAPVFTLLQGQEEALGN
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.