PharMolix/UniProtQA huggingface dataset:
Protein: MIAB_THIDA
Sequence: MKKIYIKTFGCQMNEYDSDKMADVLNAAEGLTPTSTPEDADVILFNTCSVREKAQEKVFHDLGRVRHLKQANPNLIIGVGGCVASQEGAAIVARAPFVDVVFGPQTLHRLPELIAQRRETGRAQVDISFPEIEKFDHLPPARVEGGAAFVSIMEGCSKYCTFCVVPYTRGEEVSRPFDDVIAEVANLAARGVKEITLLGQNVNAYQGALDEGGTADFAFLLEMVHEIPGVERIRYTTSHPREMTQRLIECYGKLPKLVSHLHLPVQSGSDRILAAMKRGHTVLEFKSIVRKLREQRSDLCLSSDFIVGFPGETGADFEATMKLVEELNFDASFSFIYSKRPGTPAADYADDVSAELKTQRLMRLQARIEAQAQGVNRSMVGSVQRVLVEGQARKNANELAGRTGNNRIVNFAGPSRLLGQFVDVTITQALPHSLRGEAVTLETLHT
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_PYRAB
Sequence: MKVYGLIGKPVSHSLSPVMHNALFRKYGIDAVYVTFEVEELGKAIDGVRALGISGLNVTMPYKEVVTKFLDELSEDAREINSVNTIINLEGSLIGYTTDGVGARKALERFTEIEGRNVLILGAGGAGKAIAYELSKIANIVVLNRTPSKAKSLEKFGVKGGSLDELPNYVGWADVLINATSVGMGTNESLVPRRLLRRELIVMDIVYKPLKTRLLRDAESVGCRVIDGLWMLIYQGAESFKLWTGIYPDVELMRRVSLERLGKG
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: RPIA_ENTCL
Sequence: MTQDELKKAVGWAALQYVQPGTIVGVGTGSTAAHFIDALGTMKGQIEGAVSSSDASTEKLKSLGITVFDLNEVDRLGIYVDGADEINGHMQMIKGGGAALTREKIIASVADKFICIADASKQVDILGNFPLPVEVIPMARSAVARQLVKLGGRPEYRQGVVTDNGNVILDVHGLEILDAIALENAINAIPGVVTVGLFANRGADVALIGTADGVKTIVK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: FUBP2_RAT
Sequence: MSDYSTGGPPPGPPPPAGGGGGAAGAGGGPPPGPPGAGDRGGGGPGGGGPGGGGASGGPSQPPGGGGPGIRKDAFADAVQRARQIAAKIGGDAATTVNNNTPDFGFGGQKRQLEDGDQPDSKKLASQGDSIGSQLGPIHPPPRTSMTEEYRVPDGMVGLIIGRGGEQINKIQQDSGCKVQISPDSGGLPERSVSLTGAPESVQKAKMMLDDIVSRGRGGPPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQNTNVDKPLRIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRVGGGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLLQSLRSGPPGPPGAPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQLPPNGDPNFKLFVIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGGPGPAGPMGPFHPGPFNQGPPGAPPHAGGPPPHQYPPQGWGNTYPEWQPPAPHDPNKAAAAATDPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWEEYYKKIGQQPQQPGAPPQQDYTKAWEEYYKKQAQVATGGGPGAPPGSQPDYSAAWAEYYRQQAAYYGQTPGPGGPQPPSTQQGQQQATEANGYELHL
What is the function of this protein?
Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA.  Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing.  May interact with single-stranded DNA from the far-upstream element (FUSE).  May activate gene expression.  Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity).  Binds to the dendritic targeting element and may play a role in mRNA trafficking.
What are the official names of this protein?
Far upstream element-binding protein 2, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, MAP2 RNA trans-acting protein 1, MARTA1.
What is the protein family that this protein belongs to?
Belongs to the KHSRP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.
Protein: SCAF_HHV2H
Sequence: MASAEMRERLEAPLPDRAVPIYVAGFLALYDSGDPGELALDPDTVRAALPPENPLPINVDHRARCEVGRVLAVVNDPRGPFFVGLIACVQLERVLETAASAAIFERRGPALSREERLLYLITNYLPSVSLSTKRRGDEVPPDRTLFAHVALCAIGRRLGTIVTYDTSLDAAIAPFRHLDPATREGVRREAAEAELALAGRTWAPGVEALTHTLLSTAVNNMMLRDRWSLVAERRRQAGIAGHTYLQASEKFKIWGAESAPAPERGYKTGAPGAMDTSPAASVPAPQVAVRARQVASSSSSSSFPAPADMNPVSASGAPAPPPPGDGSYLWIPASHYNQLVTGQSAPRHPPLTACGLPAAGTVAYGHPGAGPSPHYPPPPAHPYPGMLFAGPSPLEAQIAALVGAIAADRQAGGLPAAAGDHGIRGSAKRRRHEVEQPEYDCGRDEPDRDFPYYPGEARPEPRPVDSRRAARQASGPHETITALVGAVTSLQQELAHMRARTHAPYGPYPPVGPYHHPHADTETPAQPPRYPAKAVYLPPPHIAPPGPPLSGAVPPPSYPPVAVTPGPAPPLHQPSPAHAHPPPPPPGPTPPPAASLPQPEAPGAEAGALVNASSAAHVNVDTARAADLFVSQMMGSR
What is the function of this protein?
Plays a major role in capsid assembly.  Acts as a scaffold protein by binding major capsid protein.  Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid.  Cleaved by assemblin after capsid completion.  The cleavages products are evicted from the capsid before or during DNA packaging.
What are the official names of this protein?
Capsid scaffolding protein, Capsid protein P40, Protease precursor, pPR, Virion structural protein UL26.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae capsid scaffolding protein family.
What are the subcellular locations of this protein?
[Capsid scaffolding protein]: Host cytoplasm. SUBCELLULAR LOCATION: [Assemblin]: Host nucleus. SUBCELLULAR LOCATION: [Assembly protein]: Host nucleus.
Protein: FLDH_CLOS1
Sequence: MKILAYCVRPDEIDSFKNFSEKYGHTVDLIPDSFGPNVAHLAKGYDGISILGNDTCNREALEKIKDCGIKYLATRTAGVNNIDFDAAKEFGINVANVPAYSPNSVSEFTVGLALSLTRKIPFALKRVELNNFALGGLIGVELRNLTLGVIGTGRIGLKVIEGFSGFGMKKMIGYDIFENEKAKEYIEYKSLDEVYKEADIITLHAPLTDDNYHMIGKESIAKMKDGVFIINAARGALIDSEALIEGLKSGKIAGAALDSYEYEQGVFHNNKMNEIMKDDTLERLKSFPNVVITPHLGFYTDEAVSNMVEITLMNLQEFELKGTCKNQRVCK
What is the function of this protein?
Essential for the reductive metabolism of L-phenylalanine, L-tyrosine and L-tryptophan (PubMed:29168502).  Catalyzes the conversion of phenylpyruvic acid to phenyllactic acid, 4-hydroxy-phenylpyruvic acid to 4-hydroxy-phenyllactic acid, and indolepyruvic acid to indolelactic acid (PubMed:29168502, PubMed:4384683).
What are the official names of this protein?
Aromatic 2-oxoacid reductase, Indolelactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: TRUB_SULTO
Sequence: MEIYDFIYKIDSFCNYSNNWNIIQDSYTNEKYGYFADKRPIEVLIKNSIINADKPPGPTSHEVAYWIKQMFKVSKAGHGGTLDPKVTGVLPIGLENATKLMSYISSSGKEYVCLMQVHCDFNIDELKQIISKFIGIIYQKPPVRSSVKRRTRKKKIYDIEILDTDKRFILLRISSDPGTYMRKLCHDIGVILGCGAHMRELRRIRSGIFTEKNLVTLQEISEALYMWKNCKDESDLRKILLPMEYATCGMPKILIDDNAVDAISYGAMLTAPGIVAYQRFRVKDTVAILTLKGELVAIGEADVDSQKLVDMKKGIVVKPKRVLMPRDIYPRSWKKHG
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
Protein: EDN1_MOUSE
Sequence: MDYFPVIFSLLFVTFQGAPETAVLGAELSTGAENGVQSPPPSTPWRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPERVVPYGLGGSSRSKRSLKDLLPNKATDQAVRCQCAHQKDKKCWNFCQAGKELRAQSTMQKSLKDSKKGKPCSKLGKKCIYQQLVEGRKLRRLEAISNSIKASFRVAKLKAELYRDQKLTHNRAH
What is the function of this protein?
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity).  Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity).  Also binds the DEAR/FBXW7-AS1 receptor (PubMed:16293765).
What are the official names of this protein?
Endothelin-1, ET-1, Preproendothelin-1, PPET1.
What is the protein family that this protein belongs to?
Belongs to the endothelin/sarafotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KTHY_VARV
Sequence: MSRGALIVFEGLDKSGKTTQCMNIMESIPTNTIKYLNFPQRSTVTGKMIDDYLTRKKTYNDHIVNLLFCANRWEFASFIQEQLEQGITLIVDRYAFSGVAYATAKGASMTLSKSYESGLPKPDLVIFLESGSKEINRNVGEEIYEDVAFQQKVLQEYKKMIEEGEDIHWQIISSEFEEDVKKELIKNIVIEAIHTVTGPVGQLWM
What is the function of this protein?
Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate.  The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RLMN_CAUSK
Sequence: MSVTLDLSRMAPSMSKEGGDAPKALINLSGLTRAQLLVALTESGVAEHGKAKMRATQIFRWMHHRGVTDFALMTDVAKETRARLAERFTVSRPEVVERQVSKDGTRKWLIRMAPGIEVETVYIPSVGRAGALCVSSQVGCTLNCSFCHTGTQALVRNLTAAEIVAQVQIAKDDLAEWPSDKEDRLLSNIVFMGMGEPLYNLGHVADAIEIISDNEGIGISRRRITVSTSGVVPQLEALGDKTQAMLAISLHATNDALRDVLVPLNKKYPLEDLMAGVRAYPGLSNARRVTFEYVMLKGVNDSPDEARALVKLIKGIPAKINLIPFNPWPGTDYVCSDWAAIEAFGAILNKAGYSSPIRTPRGRDILAACGQLKSESEKVRASAMRKLSMAAMAGVLDDDDEAAA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODF3B_HUMAN
Sequence: MGSDAWVGLWRPHRPRGPIAAHYGGPGPKYKLPPNTGYALHDPSRPRAPAFTFGARFPTQQTTCGPGPGHLVPARMTVRGTDGAPAYSIYGRPRRSAPFLTPGPGRYFPERAGNATYPSAPRHTIAPRNWGVQAEQQSPGPAAYTVPSLLGPRVIGKVSAPTCSIYGRRAAGSFFEDLSKTPGPCAYQVVSPGVYKSRAPQFTILARTSLPQDNTRKPGPAAYNVDQHRKPRGWSFGIRHSDYLAPLVTDADN
What are the official names of this protein?
Outer dense fiber protein 3B, Outer dense fiber protein 3-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the ODF3 family.
Protein: Y841_META3
Sequence: MINEIIRESKDKNGILIDVEISSNAKKNEIGEINEWRKRLIIKIKALPVDGKANKEIAKFFKKTFGKDIIIVSGLTSSQKTICVIGATKDEIIDKILKNNI
What are the official names of this protein?
UPF0235 protein Maeo_0841.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: CCO_MYCTU
Sequence: MTTAQAAESQNPYLEGFLAPVSTEVTATDLPVTGRIPEHLDGRYLRNGPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWYRNRWVRTPAVCAALGEPISARPHPRTGIIEGGPNTNVLTHAGRTLALVEAGVVNYELTDELDTVGPCDFDGTLHGGYTAHPQRDPHTGELHAVSYSFARGHRVQYSVIGTDGHARRTVDIEVAGSPMMHSFSLTDNYVVIYDLPVTFDPMQVVPASVPRWLQRPARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYAWNPSYPARVGVMPREGGNEDVRWFDIEPCYVYHPLNAYSECRNGAEVLVLDVVRYSRMFDRDRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQEFPRINETLVGGPHRFAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTVASLDPDLLIGEMVFVPNPSARAEDDGILMGYGWHRGRDEGQLLLLDAQTLESIATVHLPQRVPMGFHGNWAPTT
What is the function of this protein?
Catalyzes the oxidative cleavage of several carotenoids and apocarotenoids in vitro.  In contrast to other carotenoid oxygenases, cleaves substrates at two different sites, namely the central C15-C15' and an excentric double bond at the C13-C14 position, leading to retinal (C20), beta-apo-14'-carotenal (C22) and beta-apo-13-carotenone (C18) from beta-carotene (C40), as well as the corresponding hydroxylated products from zeaxanthin and lutein.  Converts beta-apo-10'-carotenal (C27) into beta-apo-13-carotenone (C18) and to minor amounts of beta-apo-15-carotenal (retinal; C20) from the cleavage at the C13-C14 and the C15-C15' double bonds, respectively.  Can also cleave beta-apo-8'-carotenal, 3-OH-beta-apo-8'-carotenal and 3-OH-beta-apo-10'-carotenal.  Does not use as substrates beta-apocarotenoids that have a chain length shorter than C25.  Also cleaves lycopene into apo-13-lycopenone (C18) and apo-15'-lycopenal (acycloretinal, C20).  Moreover, is able to cleave 3,3'-dihydroxy-isorenieratene representing aromatic carotenoids synthesized by other mycobacteria.  Might be involved in the utilization of carotenoids from host cells to produce compounds required for normal growth.
What are the official names of this protein?
Carotenoid cleavage oxygenase, CCO, Carotenoid 13,14/15,15'-oxygenase.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
Protein: RPPH_BRUAB
Sequence: MSEHKGPTGAMVDPESLPYRPCVGLMVLNKAGLVWAGRRIVIPGDEMDGATQLWQMPQGGIDKGEDPAQAALRELYEETGMTSVSLLEEASDWINYDLPPHLMGLALKGKYRGQTQKWFAYRFEGDESEIAINPPPGGHTAEFDCWEWKPMADLPNLIVPFKRKVYEQVVATFRHLAA
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: RK31_CYAM1
Sequence: MKKNIHPKWYKHSIVYGNGQQILTVGSTKPELHVEVWSSIHPFYTGSQKQLDTEGRIEKFMRKYGMK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CER1_CHICK
Sequence: MSLLLLQLLVLSCLGDTEPQPDSQQRKRRPLQHLFYLDRNLLESQSFHELVGENPVGVKETQEEPSFFIAFPQTAGESQKQGEKKMSRFILPNAELYAHQDLRTWAAPKEISPVENFSPSYYSNKRDVEPPYRKDAKKFWDHFMLRKNSASEEVVLPIKTNEMHQETCRTLPFSQSVAHESCEKVIVQNNLCFGKCSSFHVPGPDDRLYTFCSKCLPTKFSMKHLDLNCTSSVPVVKKVMIVEECNCETQKIEDPLLGSRQSDFLGNLPEHN
What is the function of this protein?
Cytokine that acts as a regulator of the activity of Nodal/BMP pathways during the establishment of bilateral asymmetry in the head and trunk of the embryo.
What are the official names of this protein?
Cerberus.
What is the protein family that this protein belongs to?
Belongs to the DAN family.
What are the subcellular locations of this protein?
Secreted.
Protein: TLP_CLOBK
Sequence: MKNKPDDRRDNVDKIQYNITKTIQNCEFADEIIAKTDDEKTKKTLIEKNERRREALDGMREEIKDEARDKKNGYM
What are the official names of this protein?
Protein Tlp homolog.
What is the protein family that this protein belongs to?
Belongs to the Tlp family.
Protein: ARGC_THEMA
Sequence: MIRAGIIGATGYTGLELVRLLKNHPEAKITYLSSRTYAGKKLEEIFPSTLENSILSEFDPEKVSKNCDVLFTALPAGASYDLVRELKGVKIIDLGADFRFDDPGVYREWYGKELSGYENIKRVYGLPELHREEIKNAQVVGNPGCYPTSVILALAPALKHNLVDPETILVDAKSGVSGAGRKEKVDYLFSEVNESLRPYNVAKHRHVPEMEQELGKISGKKVNVVFTPHLVPMTRGILSTIYVKTDKSLEEIHEAYLEFYKNEPFVHVLPMGIYPSTKWCYGSNHVFIGMQMEERTNTLILMSAIDNLVKGASGQAVQNMNIMFGLDETKGLEFTPIYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARFG3_PONAB
Sequence: MGDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNANASSFFHQHGCSTNDTNAKYNSRAAQLYREKIKSLASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPAETTLENNEGGQEQGPCVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKRSLGAQKLANTCFNEIEKQAQAADKMKEQEDLAKAAPKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNVDSDRLGMGFGNCRSGISHSVTSDMQTIEQESPIMAKPRKKYNDDGDDSYFTSSSRYFDEPVELRSGSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARHKPDYEPVENTDEAQKKFGNVKAISSDMYFGRQAQADYETRARLERLSASSSISSADLFEEQRKQAAGNYSLSSVLPNAPDMAQFKQGVRSVAGKLSVFANGVVTSIQDRYGS
What is the function of this protein?
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1).  Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).
What are the official names of this protein?
ADP-ribosylation factor GTPase-activating protein 3, ARF GAP 3.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
Protein: NUOB2_BURM9
Sequence: MANHPLTLEKDGFIVTTLDAAMAAAQKNSLWYMTFGLACCAVEMMHAAGARYDMDRFGMIPRASPRQCDLMIVAGTLTNKMAPAMRRVYDQMAEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALVYGLMQLQRKVAERSTHSRPKLFARP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 2, NADH dehydrogenase I subunit B 2, NDH-1 subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: AKNT_STRGJ
Sequence: MQTQNAPETAENQQTDSELGRHLLTARGFHWIYGTSGDPYALTLRAESDDPALLTRRIREAGTPLWQSTTGAWVTGRHGVAAEALADPRLALRHADLPGPQRHVFSDAWSNPQLCHIIPLDRAFLHASDADHTRWARSASAVLGSAGGAPAEGVREHAGRVHREAADRTGDSFDLMADYSRPVATEAAAELLGVPAAQRERFAATCLALGVALDAALCPQPLAVTRRLTEAVEDVRALVGDLVEARRTQPGDDLLSAVLHAGSSAASAGQDALAVGVLTAVVGVEVTAGLINNTLESLLTRPVQWARLGENPELAAGAVEEALRFAPPVRLESRIAAEDLTLGGQDLPAGAQVVVHVGAANRDPEAFLAPDHFDLDRPAGQGQLSLSGPHTALFGAFARLQAETAVRTLRERRPVLAPAGAVLRRMRSPVLGAVLRFPLTTSA
What is the function of this protein?
Involved in the biosynthesis of the anthracycline antitumor agent aclacinomycin A.  AknT is required for the glycosylation of aklavinone aglycone by AknS to yield aclacinomycin T (rhodosaminyl-aklavinone).
What are the official names of this protein?
Protein AknT.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: METK_BACCN
Sequence: MTKQRHLFTSESVTEGHPDKICDQISDSILDAILSKDANARVACETTVTTGLVLVAGEITTSTYVDIPKIVRETIQGIGYTRAKYGFDAETCAVLTSIDEQSADIAMGVDRALEAREGQMTDAEIEAIGAGDQGLMFGFACNETKELMPLPISLAHKLARRLTEVRKDETLEYLRPDGKTQVTVEYDENGKPVRVDTIVISTQHHPEITWEQIDRDLKEHVIKAVVPAELMDEETKFFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSAAYAARYVAKNIVAAGLAEKAEVQLAYAIGVAKPVSISVDTFGTGKVSEEVLVELVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDVDLPWERTDKAADLKEQAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_CYTH3
Sequence: MIFALHGRPFKEDNIPYVQHLLYYLQKKEIQFLINESFVDYLVQCNILLPSFFTTFTNKTDLGKPDLMLSIGGDGTLLESATFIGDQNIPLVGINTGRLGFLATTPREELEGSVDELISGSYKLSERTLIKLISDEKLFGDLNFAMNEFALTKRDSSSMITVHTYIDGEFLNSYWADGLLVSTPTGSTGYSLSCGGPLVHPKTENFIITPISPHNLNVRPMIVPDSCHISFEIEGRNQNFLISLDSRAEIVSSNIKLSVKKEDFKIQLVELKNYNYYKTLRSKLNWGLDARN
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_MYCMM
Sequence: MPRKGPAPKRPLVNDPVYGSQLVTQLVNKVLLQGKKSLAERIVYGALEQARDKTGTDPVITLKRALDNVKPALEVRSRRVGGATYQVPVEVRPDRSTTLALRWLVGYSRQRREKTMIERLANEILDASNGLGASVKRREDTHKMAEANRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: VP04_OPICY
Sequence: NRTFKTNTKCHVKNQCNFLCQ
What are the official names of this protein?
Venom peptide Ocy4.
What are the subcellular locations of this protein?
Secreted.
Protein: DLTC_STAAE
Sequence: MEFREQVLNLLAEVAENDIVKENPDVEIFEEGIIDSFQTVGLLLEIQNKLDIEVSIMDFDRDEWATPNKIVEALEELR
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_THEKO
Sequence: MDWKGRDVISIRDFSKEDIEFVLKVAERLEEELNEKGSLDYARGKILATLFFEPSTRTRLSFESAMHRLGGSVIGFSSASSTSVKKGESLADTIKTVEQYSDVIVIRHPMEGAARLAAEVAGIPVINAGDGSNQHPTQTLLDLYTIKKAFGKIDGLTIGLLGDLKYGRTVHSLAEALAFYDVELYLISPELLRMPKHIVDELRERGVKVYETTDLEGAIPKLDVLYVTRIQRERFPDEEEYLKVKGSYQVNLEVLKNAKETLKVMHPLPRVDEIHPEVDKTKHALYFRQVFSGVPVRMALLGLTLGVLGV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: GON2_HAPBU
Sequence: MCVSRLALLLGLLLCVGAQLSFAQHWSHGWYPGGKRELDSFGTSEISEEIKLCEAGECSYLRPQRRSILRNILLDALARELQKRK
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Progonadoliberin-2, Progonadoliberin II.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.