PharMolix/UniProtQA huggingface dataset:
Protein: AEGA_ECOLI
Sequence: MNRFIMANSQQCLGCHACEIACVMAHNDEQHVLSQHHFHPRITVIKHQQQRSAVTCHHCEDAPCARSCPNGAISHVDDSIQVNQQKCIGCKSCVVACPFGTMQIVLTPVAAGKVKATAHKCDLCAGRENGPACVENCPADALQLVTDVALSGMAKSRRLRTARQEHQPWHASTAAQEMPVMSKVEQMQATPARGEPDKLAIEARKTGFDEIYLPFRADQAQREASRCLKCGEHSVCEWTCPLHNHIPQWIELVKAGNIDAAVELSHQTNTLPEITGRVCPQDRLCEGACTIRDEHGAVTIGNIERYISDQALAKGWRPDLSHVTKVDKRVAIIGAGPAGLACADVLTRNGVGVTVYDRHPEIGGLLTFGIPSFKLDKSLLARRREIFSAMGIHFELNCEVGKDVSLDSLLEQYDAVFVGVGTYRSMKAGLPNEDAPGVYDALPFLIANTKQVMGLEELPEEPFINTAGLNVVVLGGGDTAMDCVRTALRHGASNVTCAYRRDEANMPGSKKEVKNAREEGANFEFNVQPVALELNEQGHVCGIRFLRTRLGEPDAQGRRRPVPVEGSEFVMPADAVIMAFGFNPHGMPWLESHGVTVDKWGRIIADVESQYRYQTTNPKIFAGGDAVRGADLVVTAMAEGRHAAQGIIDWLGVKSVKSH
What is the function of this protein?
Involved in formate-dependent uric acid degradation under microaerobic and anaerobic conditions.  May reduce the enzymes necessary for uric acid degradation.
What are the official names of this protein?
Putative oxidoreductase AegA, Anaerobically expressed gene A.
Protein: DSRB_YERPB
Sequence: MKVNDRVTVKTDGGPRREGVVLEVEEFSEGVMYLVSLADYPAGVWFFNEVDSQDGTFVEPLSQ
What are the official names of this protein?
Protein DsrB.
What is the protein family that this protein belongs to?
Belongs to the DsrB family.
Protein: HDRB1_METMP
Sequence: MSETDFEYMFFLGCIAPNRYPGIESATYKALDKLGIQLHPFEQASCCPAPGVFGSFDLMTWLTIAARNIVMAEQADLDILTICNGCYGSLFEANHILQDNENARNKVNEVLSKHGLEYTGKSRVRHLTEVLYFDYGTEKIAERVERPLDINVAVHYGCHYLKPTDVKHIESSEVPKSLDGLVEAIGAKSIYYKDKNMCCGAGGGVRARNPEVALEMAETKVKNIIAAGGDCVTEVCPFCHLQFDRGQIEMKETFGREYKLPVIHYAQLLGMAMGMTPKEVALDLHFIPADPLLEKLGINME
What is the function of this protein?
Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
What are the official names of this protein?
H(2)/formate:CoB-CoM heterodisulfide,ferredoxin reductase subunit B1, CoB--CoM heterodisulfide reductase subunit B1.
What is the protein family that this protein belongs to?
Belongs to the HdrB family.
Protein: RS4_ANAPZ
Sequence: MVAVVNRKYRASRRLGVNLWGRSKDPFNTRNYPPGQHGAMGYKKLSSFGRQFVAHQKFKCYYVVSSRQLRNVFLKAYRKKGDTGDNLVGALESRLASVVYSAGLVPTMFSARQLVSHKHVTVNGRVVNIPSFSVKPGDIVEVRKRASQLPMVLAAIQSQERRVPDHLDVNTEKLSVKYLAVPKYSDVPYPANMEVNLVVEFYSG
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PGA28_CANAL
Sequence: MKFFAYFAVIALSSASLINLFKRATANGCEVESCYKAHQTLINSCNGAFDFNCLCNLPQSYFQNLYDCSKSCDTLQESDIHSPSDIRSIYCEAASNSIYTFSIDSISLDMIGYSDFETDTEATTGSDTRTKAATGATTSAGTGVTKTSETGGVSSTANSEAKSGSVTTSKSGSTSISESKTTSGSSSSGKSSSSTSSASSQQTSSHAGGASGAFVSLLGLFAALLI
What is the function of this protein?
Putative adhesin which is involved in cell adhesion and virulence (By similarity).  Plays a role in Candida-bacterial interactions and subsequent regulation of filamentation.
What are the official names of this protein?
Probable GPI-anchored adhesin-like protein PGA28, Predicted GPI-anchored protein 28.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: NDHH_BRADI
Sequence: MSLPLTRKDLMIVNMGPQHPSMHGVLRLIVTLDGEDVIDCEPILGYLHRGMEKIAENRTIIQYLPYVTRWDYLATMFTEAITVNAPEFLENIQIPQRASYIRVIMLELSRIASHLLWLGPFMADLGAQTPFFYIFRERELIYDLFEAATGMRMMHNYFRIGGVAADLPYGWIEKCLDFCDYFLRGVVEYQQLITQNPIFLERVERVGFISGEEAVNWGLSGPMLRASGIRWDLRKVDLYESYNQFGWKVQWQKEGDSLARYLVRIGEMRESIKIIQQAVEKIPGGPYENLEVRRFKKEKNSEWNDFEYRFLGKKPSPNFELSKQELYVRIEAPKGELGIYLVGDDGLFPWRWKIRPPGFINLQILPQLVKKMKLADIMTILGSIDIIMGEVDR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, chloroplastic, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase 49 kDa subunit, NADH-plastoquinone oxidoreductase subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: PNP_CHLT3
Sequence: MVFTKEIDLGQGKVLKIETGKMAKQADGSAVVSLEETMVLATVVSKKDAPPANQNFFPLQVEYREKYSAAGKFPGGFIKREGRPSDKEILSARLIDRALRPLFPDGYYQETQIIVTVISSDQLNDADVLGGIAASCALMASDIPFENPMSEVRVGRINGDFLIFPHVQELEESDMDICIGGTADTICMLEGEMSEISEAEMIGAIKFGHDVIRKICEAQRELREVVGKPKRVFEPTIIPDDMKAAIREVAEARLKELAYQPLKKEERADKTAEVYADASAAVLRKYKAEITDEILAENPEKAIYLNEKAINDYIHDIEKHVMREMILADAKRLDGRRLDEIRPISIELGLIPRAHGSALFTRGETQALVTLTLGTKKDAQLTDTLFDDADKRFMLHYNFPPFSVGEVGRMGSVSRREIGHGNLAERAIKKVVPAENAFPYTMRVVSDILESNGSSSMASVCGGTLAAMDGGVPIKSPVAGIAMGLIKEGERYAVLSDILGNEDHLGDMDFKVAGTIDGITACQMDIKIDGLDYAIVEKALEQARQGRMHILKIMDEAITSPRQELAKYAPRLTTIQIPVDAIGAVIGKGGETIRALTSETNTEIDIADDGTVTIASVSSEGSAAAVDAIKLLVSDPEVGMVYNGKVKEVRDDLGAIVEILPGVTGLLHISELSHQRGTKPSDILKVGQKTKVKLIRMAKDPKDPRRTRYSLSMKVLVEPPAEDGQKENE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXT_TROWT
Sequence: MTVGVLSLQGSFYEHLFILSRLNTDHIQVKTSEDLSRVTRLIIPGGESTAMLALTQKSGLFDLVRDRIMSGMPVYGTCAGMIMLSTFVEDFPNQKTLSCLDIAVRRNAFGRQINSFESEVSFLNSKITVPFIRAPKITQIGEGVDVLSRLESGDIVAVRQGNVMATAFHPELTGGAAVHEYFLHLGLE
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: Y1696_STAAN
Sequence: MAMTNEEKVLAIREKLNIVNQGLLDPEKYKNANEEELTDIYDFVQSRERLSPSEVTAIADALGQLRHD
What are the official names of this protein?
UPF0435 protein SA1696.
What is the protein family that this protein belongs to?
Belongs to the UPF0435 family.
Protein: DGOD_SALG2
Sequence: MKITHITTYRLPPRWMFLKIETDEGVVGWGEPVIEGRARTVEAAVHEFADYLIGKDPARINDLWQVMYRAGFYRGGPIMMSAIAGIDQALWDIKGKVLNAPVWQLMGGLVRDKIKAYSWVGGDRPADVIDGIEKLRGIGFDTFKLNGCEEMGVIDNSRAVDAAVNTVAQIREAFGSEIEFGLDFHGRVSAPMAKVLIKELEPYRPLFIEEPVLAEQEEYYPRLAAQTHIPIAAGERMFSRFEFKRVLDAGGLAILQPDLSHAGGITECYKIAGMAEAYDVALAPHCPLGPIALAACLHIDFVSRNAVFQEQSMGIHYNKGAELLDFVKNKEDFSMDGGFFKPLTKPGLGVDIDEARVIELSKSAPDWRNPLWRHADGSVAEW
What is the function of this protein?
Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
What are the official names of this protein?
D-galactonate dehydratase, GalD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: ADA2B_DANRE
Sequence: MDSPCPVAVGLPGHTNGTGGTSSPTCNQSMIKLAPYSPEATAAFATAITLMMLITIVGNILVIIAVLTSRSLRGPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRSVWCEIYLALDVLFCTSSIVHLCAISLDRYMSISRAVTYGPKRTPKRIKCAILVVWLISAVISFPPLLSMNKNKGGGESGALPQCQLNDERWYILYSTIGSFFAPCLIMILVYMRIYQIAKQRTRCPPGEPRKEAPANATTPQHKIQNGRGDETPGTLQKKARPPTLAVSQVESVQQAANTPIANNLLQAPSTTLTPTTPCPSPSPSNSSEVAPSKSKEGKKEKKKKKNNKNKNKKEPDNNNGESMSSDSDTEQGGRGLEVPCTPTMTPSGIHSPATMQKYRDMIATAKGAKLVARKAKQDGTPNSARRKAMVNREKRFTFVLAVVIGVFVICWFPFFFSYSLQAVCPESCALPEPLFKFFFWIGYCNSCLNPVIYTIFNKDFRRAFKKILCKNTKGTFF
What is the function of this protein?
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.  The order of potency for this receptor is norepinephrine > epinephrine.
What are the official names of this protein?
Alpha-2B adrenergic receptor, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor, Alpha-2BAR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DCUP_GEOSM
Sequence: MNTRFLDACWGKPVDTVPVWLMRQAGRYLPDYMRVRSKCTFLELCKTPELATEVTVQPVDILGVDAAILFSDILTPIEPMGMELDFTPGPVFAKPIRTMADVEALKIPKMETDVPYVLDAVKLLRKELAAKVPLIGFGGAPFTLACYMVEGKGSKDFAALKKMMYADPEVYAALMEKITTMDMEYLNAQIKAGAQAIQIFDTWGGMLSPADYERYVLPYTQRLINGLDRTNIPVIHFVKGAGTMLEIVKQAGGDVMGLDWHVNLGKARDILGDMAVQGNLDPTVLFAPNEIIEREVKRVLDENAGRPGLIFNLGHGILPTVPPEKAIFMVDCVHRLSRK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_THEFY
Sequence: MTATAEGTAAPTTVTGRIARVIGPVVDVEFPVGSLPPIYNALKTEVTLGGETRTITLEVAQHLGDNLVRAISLNPQDGLVRGAEVRDTGAPIRVPVGDGVKGHVFNALGEPQDIPKSELQVKEYWPIHRPAPAFDQLEAKTEMLVTGIKVIDLLTPYVRGGKIGLFGGAGVGKTVLIQEMITRIARNFGGVSVFAGVGERTREGTDLFLEMQEMGVLPDTALVFGQMDEPPGTRLRVALSALTMAEYFRDVQKQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLADEMGLLQERITSTRGHSITSMQAIYVPADDYTDPAPATTFAHLDATTELSRPISQKGIYPAVDPLTSTSRILDPQYVGQEHYEVAQRVKEILQRNHDLQDQIAILGIDELSEEDKIIVHRARRLERFLSQNMFVAEKFTGTPGVFVPLEETIASFKAICDGEYDHLPEQAFLNVGNIEMAVEKAKKLQS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FADB_SHESH
Sequence: MIYQSPTIQVELLEDNIARLCFNASGSVNKLDRETINSLDAALDAIQQDSHIQALVLTSAKGAFIVGADITEFLGLFAQEDSVLLPWIAEANVVFNKLEDLPFPTISAINGFALGGGFETVLATDFRIADTTAKIGLPETKLGLIPGFGGTVRLPRLIGTDNALEWITSGKDQRPEAALKVGAIDAVVAPENLQASAIKMLKDALAEKLDWQSRRARKQAALTLPKLEAMMSFATAKGMVFKIAGKHYPAPMAAISVIEQAARCGRADALKVEHQAFVKLAKTDVAQALIGIFLNDQLVKGKAKKAGKLAKNIDTAAVLGAGIMGGGIAYQSASKGTPIIMKDIAQPALELGLGEASKLLAAQIKRGRSTPQKMAKVLNNITATLDYTPVKDVDVVVEAVVEHPKVKSMVLAEVEQNVSDDAIITSNTSTISINLLAKSLKKPERFCGMHFFNPVHKMPLVEVIRGENSSEETIASVVAYASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSGLLADGADFAAIDKVMEKQFGWPMGPAYLLDVVGIDTGHHAQAVMAEGFPDRMGKNGKDAIDIMFEAERFGQKNSKGFYAYSVDRRGKPKKDVDPTSYELLGAEFGELKAFESEDIIARTMIPMIIETVRCLEEGIIATPAEADMGLVFGLGFPPFRGGVFRYIDTMGVANFVALADKYAHLGGLYQVTDAMRELAANNGSYYQS
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: UPP_DICDI
Sequence: MSYPENVVVLKSNHQLKGLFTIIRNRETKREDFIFYSDRIIRLLIEEGLYCLPFHETTITTPTGCEYQGVTFASKICGVSIVRAGESMEAGLRAVCKHIKIGKILIQRDEETALPKLLYAKLPHDIANRQVLLLDPMLATGGTVTQAVEVLLERGVKEENIVFINLVASPEGIKVFTDKYPRVKVVTGEIDSHLNEKKYIIPGLGDFGNLYFGTED
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UPRTase, UMP pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: IAP_ASFE7
Sequence: MFPKINTIDPYISLRLFEVKPKYVGYSSIDARNQSFAIHGIKNYEKFSNAGFFYTSPTEITCYCCGMKFCNWLYEKHPLQVHGFWSRNCGFMRATLGIIGLKKMIDSYNDYYNNEVFVKHKNRVYTHKRLEDMGFSKPFMRFILANAFIPPYRKYIHKIILNERYFTFKFAAHLLSFHKVNLDNQTTYCMTCGIEPIKKDENFCNACKTLNYKHYKTLNFSVKL
What is the function of this protein?
Prevents apoptosis of host cell by inhibiting caspase-3/CASP3 activation to promote the viral replication.  Induces also the activation of host NF-kappaB.
What are the official names of this protein?
IAP-like protein p27.
What is the protein family that this protein belongs to?
Belongs to the asfivirus IAP family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion. Note=Probably accumulates in the perinuclear cytoplasmic viral factories. Found in association with viral nucleoid.
Protein: CYSG1_AERHH
Sequence: MDFLPLFCQLQHKPVLIVGGGEVAVRKARLLLDAKARVTINAPHLEPQLMSWAEQGLLTVCAADFHPELLDGKWLVIAATNQPEVNQQVFNEANRRQIFCNVVDSPAHCSAIMPAIIDRSPLMVAISSAGSAPLLSRQLREKIEALLPQHLGQLATLAGKLRERVKAIPDKLARRRFWERLFSHERLACQLARGQQQAAEESVAELLNEPQQSKGSVTLVGAGPGDAGLLTLNGLQQLQQADVVVYDRLVSQEVLAHVRRDAERIFVGKEAGCHCVPQQAINQLLLEQARLGKQVVRLKGGDPFIFGRGGEELETLAEAGIPFSVVPGITAASGCAAYSGIPLTHRDHAQRVQFITGHDKEGNIAQEWPALATPRQTLVFYMGLAHAGRIQDELQTHGLPGHTPVALVEQGTRLQQRVVRGKLQQLAQLATQVESPSLIIIGSVVTLADKLDWYGEANTLAGV
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: RECO_PROM3
Sequence: MSGERRLNGLSLKVGPLGEHDRLLTLLSDQEGVTRLAVPGARRPRSSLAAAVPLSLLELQVAGRRGLARVRQLKVLRSFNSVGKQLETLAAAQALAELSLMLVAGNDPLPGLLNTLLMHLERLEALSQAQPAQPNTTLACSVQACVHLLALGGYGLPVQECCRNGTALEPPLGQWEWRCSLMPEEGFAIGALPGAALQLNPSELALLQRLLRPALPMRRDGELMGPPEVWLRLLAVVECWIRTHLPHHMRALGMLREAIISSGDGRT
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: MUTS_EHRRW
Sequence: MTNSNSITPVMQQYVTLKQQYKEYLLFYRLGDFYELFFDDAIKTSKILNIVLTKKGNVPMCGVPFHSSETYLNKLVKLGYKIAICEQLETSEEARKRGYKSLVKRDVVRIVTPGTIVEDSLLEAKESNYLACIVMIKDSCAIAWLELSTGLFCYHMTYISKLDSDLLRIGPKELLVADDLLEIEAVYSIIKKYRFSITQYSSSFFDENRAYNTLCNVYGVSTLKGLGDLKGVEISVCGSLLEYVIATQKGSLPKLGFPKAYVQSDFMFIDAAALRNLELFSTQSGELEGSLIASIDFTVTASGGRLLKRCLSAPLASADAINRRLSVVEFFVNNQNLYKSVRQVLRGIADIERILTRVKIARCSPKDLYSLKLTLEKTCELVELLCKFNIDIISEFCLRLGRYEDLICILNNSLLQNSVSSVKDGGFINPECDAQLSEYIYIQECSNQLIQELRDRYRNITNIQSLKILYNNILGYYVEVSSNHLIDDKNFIHRQSLANNVRYTTTELKELESKIISAKDASISLEIKIFGQLCSDVIKYADKITITAHTIAEIDMLTSFAELAVQYSYSKPIIDDSYEFNIKKGKHPVVERNGKFIANDINLSSEQRVHLITGPNMAGKSTFLRQNALIGILAHIGSFVPAEYAHIGVIDKVFSRVGASDNIVCGYSTFMVEMIETAAVINQATERSFVILDEIGRGTGTYDGLSIAWSVIEQIHNVNKSRAIFATHYHELSKLDKYLKHIKCFCMKVEEWDGKVVFLHEIIPGASDKSYGIHVAKLAGFPQSVVNRAEYLMDKLKTNEDLLT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: LEXA_MYCSS
Sequence: MSDDSSETRTGGRRGADAGLTERQRTILEVIRASVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVDVRLSDEPATPVVTTDVAGSDALPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGEGSLFLLKVVGDSMVDAAICDGDWVVVRQQAVADNGDIVAAMIDGEATVKTFKRSRGQVWLMPHNPAFEPIPGNDAAVLGKVVTVIRKI
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: HLP_RICTY
Sequence: MTITKNKISLMLNSKLGFSNNLCEEIVNTVFSNILEIAKVQKLTLKNFGSFEVKQKKQRPGINFHTKSPVMIASKKNLRFSPSEKLKALINKSMR
What are the official names of this protein?
Histone-like DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: LAMBV_CHICK
Sequence: AATTLRRGGGREPTPPATPPTHARPDPTRRHPDPESRAPPHARPRSPPPPAPSPPPLPPRPAAVRAGRDRVGRVFSRLPPGCAAGSCYPATGDLLVGRAPRLSASSTCGLRRPQPYCIVSHLQEEKKCFICDSRRPYDARSNTDSHRIENVLTTFAPRPKKAWWQAENGVEHVSIQLDLEAEFHFTHLIMTFKTFRPA
What is the function of this protein?
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
What are the official names of this protein?
Laminin subunit beta-1 variant, Laminin beta-1-2 chain.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
Protein: GLYC1_DICDI
Sequence: MGSVSGNTPLKEVDNEIFELMNREKDRQFKGLELIASENFTSRAVMEALGSHFTNKYAEGYPGSRYYGGTEVVDELETLCQKRALKAFRLDESKWGVNVQPYSGSPANFAVYTALLRPHDRIMGLDLPSGGHLTHGYQTDKKKISASSIFFESMPYQIGADGLIDYQRLEENALLFKPKLIISGASAYPREWDYKRMRAIADKVGAYLMCDMAHYSGLVAAQLLDSPFDYCDVVTSTTHKTLRGPRSGIIFFRRGKRVDGNGKEIEEYDIESKINFAVFPSLQGGPHENVIAGVAVALKEADSQEFKEYALQVKKNAAAIGNALMNKGYKLVTNGTDNHLILWDLRPKELTGNKFEKAADIANITVNKNAVHGDTNAISPGGIRIGSSALTSRGLKEADFEKIADFLDRIVSISLEIQGRVGKKLVDFVVEINKSKELLDLRKEVEEFSSKFTLPGI
What is the function of this protein?
Interconversion of serine and glycine.
What are the official names of this protein?
Serine hydroxymethyltransferase 1, SHMT 1, Glycine hydroxymethyltransferase 1, Serine methylase 1.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
Protein: KCY_RICTY
Sequence: MVDLKTKAFDIAQNFTISLDGPAASGKGTIGLILAKKFALKYFQSSIVYRQLAFNCIHQQIDITDIDAVIALSQELKLDNNIDLENEDIGDIASKIAVISEVRNNLNHNLINLVKTTPRIIMEGRDIGTVVAPDADLKIFITASPYVRAVRRYNQLQAKGKTCILDEIIQQIILRDKRDKERKVGPLLPALGAFIIDTSKLSAIEVVEEVTNYIKNKIT
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEPA1_CAEEL
Sequence: MTPLSALTSNPAPSPPPKFALGKCPATAIHVVSVLRPNRQRFCYEKTDAGDLIPHKCLICQPILTEKHISPYYAVYSDLLEDFVLFGYNTMTGKMEQFIYAFKTDCFVEVNRPEIKYNPAFLVKGNVVVALNGPEGELVVIERDCRGLLSKESTSYGQFRTLPTAALRTLTLQDLERDRWDRAANSDEVKISSGNESFDRLYAEYQKNLPRFQVRQCLHLNKEFLCVYSKTSGDYTRLEYIDETGDFQKISCTLCTCEVTESNLIPLYVERNASELVIHVHNTENNQIEQYIYDVRTFGFVQVKRNLVYDPKKITSGLNLFMAENIDNRKVYMIMRGRDGRLQKETSGSGGFEKMQPVAVKTFQVQWVEMKTEFEKKKASTERVEPQHPVQTEGEDIMETVLAMVESFNCDLRKELGLTQDQEIPRKAPRVESAETEENIVKNLEKLQIAKDPEEPTTAASEGGNTYGYQELDDTMSEGLLEKEAESKHQDANEPEPVKNVTYEPDVAAMDKKKKRRELKSRLNKINAQIDELEKRRMERAGKKQVVSSSVPSEEAAQVEAPASPALAENTNQISNEETPKIDIFEGYNGSFLFGTNTSKEWIVEDIRNHMVGKLLKAFWPRIQNVEEMNGELFKKLIANARKCETEILEASNDRDEYYRLMQLTVDQILKKTLKKDQRATEHNHQQPTQSSDELAKNHEKN
What is the function of this protein?
Adapter protein that connects P-granules in somatic cells with the autophagic machinery (PubMed:19377305, PubMed:19372764, PubMed:19167332, PubMed:24140420).  Association with other adapters such as epg-2 and P-granule components such as pgl-3 is required for the accumulation and degradation of P-granules by autophagy in somatic cells (PubMed:19372764, PubMed:19167332, PubMed:24140420, PubMed:28806108).  This ensures exclusive localization of the P-granules in germ cells (PubMed:19372764, PubMed:19167332, PubMed:24140420, PubMed:28806108).
What are the official names of this protein?
Protein sepa-1, Suppressor of ectopic P granules in autophagy.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasmic granule. Note=Diffuse cytoplasmic localization, but also localized to cytoplasmic aggregates throughout development (PubMed:19167332, PubMed:21802374). Co-localizes with epg-2 and lgg-1 in cytoplasmic aggregates (PubMed:19167332, PubMed:24140420).
Protein: SYS_BIFLS
Sequence: MLDIQFIREHTDIVKESQRKRGESVELVDEVLSSDTARREALKAFEEARAQQKEIGKKVASVPADEKAKLIAETKELSQTVAEYKAKADSAAEEYTTAMWRLSNIVEPEAPEGGEDDYVVVKKVGQIRDFAAEGFEPKDHLTLGAGVAGIDMRRGVKVGGSRFYFLRGQVARMQIAMLTMAVDQAEEHGFTLAITPTLVRPEVMRGTGFLNSHADEIYRLREPDDQYLVGTSEVALAGMHENEILDLGNGPLRYCGWSSCYRREAGAAGKDTSGIIRVHQFDKVEMFVYAKQEDSYKEHEHLLAMEQEMLAKVEVPYRIIDTAAGDLGSSAARKFDCEAWVPTQGRYRELTSTSNCTEYQARRLNIRERMEDGGTRPVSTLNGTLATTRWLVAIMENHQQKDGSIEIPKAMRAYMGGKEVIEPTKWEA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEX19_CRIGR
Sequence: MAAAEEGCDAGVEADRELEELLESALDDFDKAKPSPAPPPTTSAPDASGPQKKSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDANSQQEFTSCLKETLSGLAKNATDLQNSGMSEEELTKAMEGLGMDDGDGDGNILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHQESIPPEQFEKYQEQHSVMGKICEQFEAETPTDSEATHRARFEAVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDTLNLSGPPGANGEQCLIM
What is the function of this protein?
Necessary for early peroxisomal biogenesis.  Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs).  Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3.  Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
What are the official names of this protein?
Peroxisomal biogenesis factor 19, Peroxin-19, Peroxisomal farnesylated protein.
What is the protein family that this protein belongs to?
Belongs to the peroxin-19 family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Lipid-anchor; Cytoplasmic side. Note=Mainly cytoplasmic. Some fraction is membrane-associated to the outer surface of peroxisomes.