PharMolix/UniProtQA huggingface dataset:
Protein: RS29_NEUCR
Sequence: MSHESVWNSRPRTYGKGSRSCRVCTHSAGLIRKYGLNICRQCFREKANDIGFTKHR
What are the official names of this protein?
40S ribosomal protein S29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: SUCC_HALHL
Sequence: MNLHEFQAKHLFTEAGIAIPRGYVARSSAEARAAAERLGGSAWVVKAQVHAGGRGKAGGVRVIQEGDEIERYADSLLGERLVTHQTDGRGQPIHALLVEEGLEIARELYLGALVDRASQRVVFMVSAAGGMDIEEVAASEPERIHTVRVHPAAGLQPYQCRQLGFALGLDKAQVGDLTRMMQGLYRLFLERDLSLVEINPLIVTGEGRLLALDAKVTVDDNAVEIGRQSQIQDMRDLTQEDETEVRAAEHNLNYITLDGNIGCMVNGAGLAMATMDVIKLHGGAPANFLDVGGGTNAERVAEAFKIILSSPSVEGILVNIFGGIVRCDMIAEGIVAAVQDVGVEVPVVVRLEGTNVEQGKQILADSGLDLIPADDLADAAAKIVDIAGQVA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: DRS9_PHYTB
Sequence: GLWSKIKDAGKAVLKAAGKAALGAVTDAV
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Dermaseptin-9TR.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPE_BUCAT
Sequence: MNFYLDVVSLTKTIFSGFVEKIRVSGSEGELGIYPGHAQLLSILKPGMVYIFHKKDKKEECIYISGGILEVQPSVVSILADVAIHAIDLDRSRILKTKKNAEESIKSNNTKINKDAILLQISKEIAKLRVLEVMDKFK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PRIB_SALTY
Sequence: MTNRLALSGTVCRAPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIVSGHENQAITHSITVGSRITVQGFISCHKAKNGLSKMVLHAEQIELIDSGD
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).  During primosome assembly it facilitates the complex formation between PriA and DnaT.
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: APT_MYCCT
Sequence: MNLKEFVVDVKDFPQKGIIFKDITPLLNNKDAFKYMIDTIAEFVKQLDVDVIVAPEARGFLLASAVAYATNKRFVLVRKPNKLPREVYDVEYSLEYGTNHQQIHKEDLKPNDKVVVIDDVLATGGTMQAIIDLVKLSKAEVVGMSFLIDLTFLHKEDLFSEYQVQKLIKY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIPA_BACSU
Sequence: MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERAMDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVDAYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQLEFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYNDYVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLVAVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIEERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIKEIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGLIGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIEDRGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMSLEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS
What is the function of this protein?
A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation.  Binds GTP and analogs.  Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
What are the official names of this protein?
50S ribosomal subunit assembly factor BipA, GTP-binding protein BipA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Binds to ribosomes.
Protein: RUVC_RHORT
Sequence: MRLLGLDPGLRITGWGVIEVTGNRIGHVADGVVRSDDRLSLAARLAQLHGGIVAVLKAYEPVEAAVEETFVNRNPASTLKLGQARGAVMLAPALAGLVVAEYQPSVVKKAVVGTGGAAKDQVGMMIRTLLPGATLETADAADALAIAICHAHYRAGALSLALARAGGGR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: KDSB_SOLUE
Sequence: MPRKILGVIPARFSSTRFPGKVLAQIANKTMLQHVYERAGLATYLTSTIIATDDERVYTAAKSFGARVRMTRADHLSGTDRVAEVASAENAEIIVNIQGDEPLIDPAAIDAAVLPLVHEPDVLMGTLKKRIEDPREIVDPNVVKVVTDHAGDAIYFSRCPIPFDRDRSADTPYFKHVGLYVYQRDFLLSYSTLPVGPLERSERLEQLRALENGYRIRVVETEYESLGVDTPEDLERVSRLFKASILQGMGNG
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGALB_EMENI
Sequence: MIEFLALITLISRANALMRPDGVGRLPALGWSSWNAHECDINATVILTAAAQVVKLGLKDLGYEYINIDDCWSIKTHRDPTTNRMIPDADRFPDGIASVASQIHELGLKVGIYSSAGETTCAGYPASLGYEDIDAETFAEWEIDYLKYDDCGVPDNWKDPYTFCVPDTANNAGPFPNGTCPSLPNPAPANYNWSTSPSAERFRRMLDALNTQDRTILYSLCNWGNAAVNTWGAEIGNSWRMSGDISPGRGEVGPDRTRIAVWERIAEITNEMSFLVREYAEFWGWPDADMLEVGNGEGGMTVAENRAHFALWAAMRSPLLIGTKLDTIRQEHLKILKNPTLLTFHQDPIINRPAYPYKWGYNADYTFDAAHPAEYWSGPSPALEGTLVVMLNSENVTSTRMAVWSEVPELQNQDQGDAFEVMDGWTGEDLGCIKEKYEVELDAHDAAVLVVGNAC
What is the function of this protein?
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
What are the official names of this protein?
Probable alpha-galactosidase B, Melibiase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOD_ANAMM
Sequence: MLPMSDTRSSRIKPMTLNFGPQHPAAHGVMRLILEMSGEVIERIDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSPMSQEHAYSLCVEKLLQCVVPPRAKYIRVIFCELTRVLNHLLNVSSQALDTGATTPLLWMFEERERLLSFYERASGARFHAAYIRPGGIAADVPDGLLDDIHAFTESFPKLLDDVDGLLTENSIWKQRNVDIGVVSKAQALDWGFSGPMLRACGIPWDLRKSQPYEIYETLDFKVPVGSNGDCYDRYLVRMAEMRESISIIRQCLNGIPEGPVKTDDRKIAPPRREELKYSMEALIHHFKLFSEGYKVPEGEAYVAVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQAIDAMARGHMLADLTAIIGSLDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CAPSD_HBOC2
Sequence: MPPIKRQPGGWVLPGYKYLGPFNPLENGEPVNKADRAAQAHDKSYSEIIKSGKNPYLYFNKADEKFIDDLKNDWSLGGIIGSSFFKLKRAVAPALGNKERAQKRHFYFANSNKGAKKPKNNEPKPGTSKMSENEIQDQQPSGSMEERGGGGGAVGSVGGGKGSSVGISTGGWVGGSYFTDSYVITKNTRQFLVKIQNDHKYRTENIIPSNAGGKSQRCVSTPWSYFNFNQYSSHFSPQDWQHLTNEYKRFKPRKMHVKIYNLQIKQILSNGADTTYNNDLTAGVHIFCDGEHAYPNATHPWDEDVMPELPYETWYLFQYGYIPVIHELAEMEDANAVEKAIALQIPFFMLENSDHEVLRTGESTEFTFDFDCEWINNERAYIPPGLMFNPKVPTRRAQYIRQHGNTASSNTRIQPYAKPTSWMTGPGLLSAQRVGPAGSDTASWMVVVNPDGAAVNSGMAGVGSGFDPPSGSLRPTDLEYKIQWYQTPAGTNSDGNIISNPPLSMLRDQALYRGNQTTYNLCSDVWMFPNQIWDRYPITRENPIWCKKPRSDKNTIIDPFDGTLAMDHPPGTIFIKMAKIPVPSNNNADSYLNIYCTGQVSCEIVWEVERYATKNWRPERRHTALGLGIGGEENVNPTYHVDKNGKYIQPTTWDMCYPIKTNINKVL
What is the function of this protein?
Capsid proteins self-assembles to form an icosahedral capsid with a T=1 symmetry, about 26 nm in diameter, and consisting of 60 copies of three size variants of the capsid proteins, VP1, and VP3, which differ by the presence of an N-terminal extension in the minor protein VP1.  The capsid has a channel at the 5-fold axis and there are densities extending the 5-fold axis into the interior of the capsid.  The capsid encapsulates the genomic ssDNA (By similarity).  Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region.  The additional N-terminal region of isoform Minor capsid protein VP1, called VP1u, may serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).
What are the official names of this protein?
Minor capsid protein VP1.
What is the protein family that this protein belongs to?
Belongs to the parvoviridae capsid protein family.
What are the subcellular locations of this protein?
[Isoform Minor capsid protein VP1]: Virion. Host nucleus. Host cytoplasm. Note=Slightly detected in the cytoplasm, mainly seen in the nucleus. SUBCELLULAR LOCATION: [Isoform Minor capsid protein VP2]: Virion. SUBCELLULAR LOCATION: [Isoform Major capsid protein VP3]: Virion. Host nucleus. Host cytoplasm. Note=Slightly detected in the cytoplasm, mainly seen in the nucleus.
Protein: DRUC_ECOU4
Sequence: MSYQYSQEAKERISKLGQSEIVNFINEISPTLRRKAFGCLPKVPGFRAGHPTEIKEKQKRLIGYMFQSHPSSEERKAWKSFSLFWQFWAEEKIDKSFSMIDNLGLKENSGSIFIRELAKNFPKVARENIERLFIFSGFADDPDVINAFNLFPPAVVLARDIVVDTLPIRLDELEARISLIADNVEKKNNHIKELELKIDAFSERFDNYFNNEKSNLKIINELQSLINSETKQSDIANKSIDELYHFNEKNKQLILSLQEKLDFNALAMNDISEHEKLIKSMANEISELKNALTILCDNKRKNNELDYINELKKLTERIDTLEINTSQASKVSVTNRFTKFHEIAHYENYEYLSSSEDISNRISLNLQAVGLTKNSAETLARLTLATFVSGQIIQFSGSLADIIADAIAIAIGAPRYHIWRVPVGIISDMDSFDFIETIAESSRCLLLKGANLSAFEIYGAAIRDIVVQRQIHPTNYDHLALIATWKQGPATFPDGGMLAELGPVIDTDTLKMRGLSAILPQLKPGCLAKDKWTNIDGLQLDSVDDYVDELRALLDEAGFDGGTLWKRMVHIFYTSLIRVPNGNYIYDLYSVLSFYTLTWAKIKGGPVQKIEDIANRELKNYSAKISS
What is the function of this protein?
Component of antiviral defense system Druantia type I, composed of DruA, DruB, DruC, DruD and DruE.  Expression of Druantia in E. coli (strain MG1655) confers resistance to phage lambda, SECphi18, SECphi27 and T4.
What are the official names of this protein?
Druantia protein DruC.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAMA_THAAR
Sequence: MNPTTQKLVEQNAPAQLVDHNLVPETVCPGVLYEKRPARNLKGEVVPGLYNVWISLDNPKQYNSYTTDMVKGLILAFRAASCARDVASVVFTAVGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSAILGCDKPVICRVNGMRIGGGQEIGMAADFTVAQDLANFGQAGPKHGSAAIGGATDFLPLMIGCEQAMVSGTLCEPFSAHKANRLGICMQIVPALKVDGKFIANPLVVTDRYLDEFGRIIHGEFKTGDELAAGKELMKRGEIDLSLLDEAVEKLCAKLISTFPECLTKSFEELRKPKLDAWNRNKENSRAWLALNMMNEARTGFRAFNEGNKETGREIEFTDLRQALAKGMPWTPELIESLMPGAK
What is the function of this protein?
Involved in the central benzoyl-CoA catabolism.  Catalyzes the addition of one molecule of water to the double bond and the hydrolytic cleavage of C-C bond in the alicyclic ring, 6-oxocyclohex-1-ene-1-carbonyl-CoA (6-OCH-CoA) to yield 3-hydroxypimelyl-CoA.
What are the official names of this protein?
6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase, 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase, Beta-oxoacyl-CoA hydrolase, Oah.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: TILS_HAEIN
Sequence: MDLLSDIEKQLQKATAQAFLIALSGGLDSTVLLSLFAKLCQKQPHLPPLSIRAIHIHHGLSPNADSWAKHCQDLCDQFQIPLIIERVQVDKTNGIEAGAREARYQAIKKYLQTQEMLVTAHHLNDQTETFFLALKRGSGLKGLGAMQQQSVLFGMPILRPLLGFTRTQLENYAQKEKLNWITDESNEDNRYDRNFLRNEILPELRERWAHFDLAVQRSAQHCFEQQQLINDLLSEIFTEHCQIKNQFKLCQFRQYSLAKQTALLRMWLAENQLEMPSKRQLTQLINDVIFAKEEANPQFQLVNKVIRRYQDSLYLTKPFSDLTKCTLKLEQNTLNLPDDLGNLTVQENEHNLIFYWQDYSVTLEKTNLPISIRFGYSGKVKHYPKRPREDIKKIWQELGVPPWERNRIPLIFYGNELKSAVGFFRVLKSS
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GFI1_MOUSE
Sequence: MPRSFLVKSKKAHSYHQPRSPGPDYSLRLETVPAPGRAEGGAVSAGESKMEPRERLSPDSQLTEAPDRASASPNSCEGSVCDPCSEFEDFWRPPSPSVSPASEKSLCRSLDEAQPYTLPFKPYAWSGLAGSDLRHLVQSYRQCSALERSAGLSLFCERGSEPGRPAARYGPEQAAGGAGAGQPGRCGVAGGATSAAGLGLYGDFAPAAAGLYERPSTAAGRLYQDHGHELHADKSVGVKVESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQHGLK
What is the function of this protein?
Transcription repressor essential for hematopoiesis.  Functions in a cell-context and development-specific manner.  Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes.  Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.  Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:17197705).  Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (PubMed:17197705).  Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling.  Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752).  Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth.  Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters.  Required for the maintenance of inner ear hair cells (PubMed:12441305).
What are the official names of this protein?
Zinc finger protein Gfi-1, Growth factor independent protein 1.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.
Protein: RSMA_NOSP7
Sequence: MIRPRKVFAQHWLKSEKALDAIIKAAECTESDRSPKGDCILEIGPGTGILTRRLLPLVQSLIAVEIDRDLCQLLSKQLGKTENFLLLQGDFLTLDLPSYLVAFPNFQKPNKVVANIPYNITGPIIEKLLGTIANPNPEPFDSIVLLVQKEVAERLYAKPGSKTFGALSVRVQYLAECELICTVPASAFHPAPKVDSAVVRLRPRKIEIPALNPRQLETFLKLGFGAKRKMLRNNLQSVIERDRLSHLLEQLKINPQARAEDISVQQWVILANELAVASGEQGVGNR
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEMA5_RAMPS
Sequence: GCIATGSFCTLSKGCCTKNCGWNFHCNPPNQ
What is the function of this protein?
Highly potent toxin against both insect and some mammalian sodium channels (Nav) (PubMed:34445875).  It potently inhibits inactivation of insect sodium channels of B. germanica (BgNav1) (EC(50)=7. 8 nM) and also delays the inactivation of mammalian Nav with potent activity on Nav1. 3/SCN3A and Nav1. 4/SCN4A (hNav1. 1/SCN1A; EC(50)=102. 1 nM, rNav1. 2/SCN2A; EC(50)=156. 1 nM, rNav1. 3/SCN3A; EC(50)=9. 4 nM, rNav1. 4/SCN4A; EC(50)=15. 4 nM, hNav1. 5/SCN5A; EC(50)=132. 7 nM, mNav1. 6/SCN8A; EC(50)=66. 9 nM, hNav1. 9/SCN9A; EC(50)=73 nM) (PubMed:34445875).  1 uM is enough to completely inhibits the inactivation, resulting in sustained non-inactivating currents (By similarity).  In addition, the toxin significantly enhances the recovery from inactivation, and the open state is not required for the toxin to interact with the channel (By similarity).  In vivo, injection into brine shrimp (Artemia salina) stops movement or causes death after 24 hours (EC(50)=0. 4 uM) (PubMed:34445875).
What are the official names of this protein?
Nemertide alpha-5.
What is the protein family that this protein belongs to?
Belongs to the nemertide family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS10_TROW8
Sequence: MEEQKIRIRLKSYSHEIIDVSAKKIVDTVTRAGATIVGPVPLPTKKSVVCVIRSPHRHKDSREHFEMRTHKRLINVVDLTPRAVDALMRLDLSSEVNVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: AGN1_APLCA
Sequence: MPCTPNSHRLLLVTALCLLITSLFAQQKRRPRIDCTRFVFAPACRGVSAKRALDPRAVTLDENVAPSFSDLDDEILRSFLAYNRHKQQEQAAPRPDAPSSLLRLVAQRGLRHRTPHSLHRPVPWSVEQSFLKTGSDGALSWPNSIKSLQED
What are the official names of this protein?
Abdominal ganglion neuropeptide L11.
What are the subcellular locations of this protein?
Secreted.
Protein: MRAY_KINRD
Sequence: MRTVLIAGAFSLVVSLFGTPLYIRWLVRRGYGQFVRDDGPTSHHTKRGTPTMGGVVIILAALLAYGAAHLFTGALPTVSGLLVLLLMTGLGVVGFLDDFLKISNQRSLGLTAKAKLAGQGLVGIVFAVLALQFPAAGKDGTTPASTHISVLRDTPLDLAVFGAVGGTVLFVVWALIITSAVSNGVNLTDGLDGLATGATTMVLAAYVLICTFQSNQSCYSLTEVEARCYEVRDPRDLAVVAAAVMGACFGFLWWNASPAKIFMGDTGSLALGGALAGLAILSRTQILLVLLGGLFVLITLSVILQVGSFKLTGKRIFRMAPLQHHFELAGWGEVTIVIRFWIIAGLFVFLGLGVFYAEWVTGA
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PATR_MYCVP
Sequence: MSARLRPELADLPAYAPGKTVPGAIKIASNETVHGPLPSVRAAIEKAIDGINRYPDNGYVELRERLAKHVNFAPEYISVGCGSVSLCQQLIQITSTVGDEVLFGWRSFEIYPLQVRTAGATPVQVPLTDHTFDLDAMLAAITDRTRLIFVCNPNNPTSTVVDPDALARFVEAVPPHIMVVVDEAYVEYIRDGLAPDSFGLVRAHSNVVVLRTFSKAYGLAGLRIGYAVADPDIIAALSKVYVPFTATSVSQAAAIACLDAADELLERTDAVVAERTRVSAALREAGYDLPPSQANFVWLPLVGRAQQFAADAANSRVIVRPYGEDGVRVTIAAPHENDAFLGFARGWDGLR
What is the function of this protein?
May catalyze the transamination reaction in phenylalanine biosynthesis.
What are the official names of this protein?
Putative phenylalanine aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: ATPG_RUMA7
Sequence: MANMKDVKRRIKSVESTMQITKAMQLVASSKMRKAKERAEAVHPFFEGVFQVMADISRDHEFTSVFTKKKFKNSVLLIVIAGDRGLAGGFNTNVLKLAKAKADAITESGGEAVIMAIGKKAVEYFEKREYKLIDGFPQIAEGIELIDAMMIANKVIERFKIGDFDAVELVYTTFVSVMTQEPQHLRILPVENLEYLGQKHPMTIYDPSPEEVFDSLIPEYMGGMLYSAIVDSFASEQAARRTAMESASDNANEMIEKLSLLYNRARQAQITQEITEISSASLNDNS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CJ090_MOUSE
Sequence: MISPVVISRLIDEKKSMENGAILPQAIAQPQLCPTKPALARRDGVSMHRRFALSPDRLGILTPSDDQGLETEPLSTGDNLGKGSHSGFSSITITARRVGPPASSLVWDTFRDPLCPKCKAKDALFQEPPVLAGDAHLCQHNRPFTCTESPSNGSVEGMKVFQAHSRLSARQDYWVTHTNDNEDSFSSDNSPSRKVPLVFSSCVHFRVSQQCPNAIYYLDKSLSVPLERPQIASPKMHRSVLSLSLRCSSHQLTADGVDSSANGEPISTALSQELSEGKQDLLGPQWGQPQGGHWKESPALVPVHLGSGTCPRTGSPPLENVKFADVGRNQVPVRKEKEDHATCTSSSHTNQLSIHIPGWSYRAETKVLSGSKKQQQEAQRTLPAFPVGQKTIKHFPPEGDSSPSSDGQPSILSESNERQHPYFMIPRVPLPGFYCPLQTGCASLQEDGAVQIETHFPKDYTCCDLVVKLKECEKNEDPTVTPEPSPATPSPSTPEGAQSSDPSEDSYEPLLASSMTLQEALEVHRPQFISRSQERLQKLKRMVQQRKTQQKESLGQKQSLLPVRANKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYNNLPEVKKKKEEQKKRMILQSNRLRAEVFKKQLLDQLLQRNAV
What is the function of this protein?
Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage (PubMed:20843368, PubMed:20154723, PubMed:24240685).  Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53.  Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2).  Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response (PubMed:24240685).  Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner.  Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (PubMed:20154723).  May have a role in the assembly of primary cilia (By similarity).
What are the official names of this protein?
(E2-independent) E3 ubiquitin-conjugating enzyme FATS, Centrosomal protein C10orf90 homolog, E2/E3 hybrid ubiquitin-protein ligase FATS, Fragile-site associated tumor suppressor homolog, FATS.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin (By similarity).