PharMolix/UniProtQA huggingface dataset:
Protein: TTCA_BRUSI
Sequence: MNAFDTDITEHADSSGCHPLFRDVPATVEFNKLRKRLLRLTRQAIEDFAMVKPGDRWMVCLSGGKDSYGLLALLLDLKWRGLLPVELLAVNLDQGQPNFPKHILPDFLTRYGIEHRIEYQDTYSIVTDKLPETSTYCSLCSRLRRGNLYRIAREEGCSAIVLGHHREDILETFFMNLFHGGRLAAMPPKLLNDEGDLMVFRPLAYAAEDDLEKFANAMQFPIIPCDLCGSQDGLQRNAMKAMLIDIEKRMPGRKDTMIRALTNVRPSHLLDRKLFDFAGLMANGEKGSDDALW
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIMA_DROME
Sequence: MVSLIDTIEAAAEKQKQSQAVVTNTSASSSSCSSSFSSSPPSSSVGSPSPGAPKTNLTASGKPKEKRRNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERLLMAIGRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDSSLPSLCSPNSLTQEDDFSFEAFAMRAPYIPIDDDMPLLTETDLMWCPPEDLQTMVPKEIDAIQQQLQQLQQQHHQQYAGNTGYQQQQQQPQLQQQHFSNSLCSSPASTVSSLSPSPVQQHHQQQQAAVFTSDSSELAALLCGSGNGTLSILAGSGVTVAEECNERLQQHQQQQQQTSGNEFRTFQQLQQELQLQEEQQQRQQQQQQQQQQQQQQQLLSLNIECKKEKYDVQMGGSLCHPMEDAFENDYSKDSANLDCWDLIQMQVVDTEPVSPNAASPTPCKVSAIQLLQQQQQLQQQQQQQQNIILNAVPLITIQNNKELMQQQQQQQQQQQQEQLQQPAIKLLNGASIAPVNTKATIRLVESKPPTTTQSRMAKVNLVPQQQQHGNKRHLNSATGAGNPVESKRLKSGTLCLDVQSPQLLQQLIGKDPAQQQTQAAKRAGSERWQLSAESKQQKQQQQQSNSVLKNLLVSGRDDDDSEAMIIDEDNSLVQPIPLGKYGLPLHCHTSTSSVLRDYHNNPLISGTNFQLSPVFGGSDSSGGDGETGSVVSLDDSVPPGLTACDTDASSDSGIDENSLMDGASGSPRKRLSSTSNSTNQAESAPPALDVETPVTQKSVEEEFEGGGSGSNAPSRKTSISFLDSSNPLLHTPAMMDLVNDDYIMGEGGFEFSDNQLEQVLGWPEIA
What is the function of this protein?
Functions as a transcriptional regulator of the adaptive response to hypoxia.  Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters.
What are the official names of this protein?
Protein similar.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
Protein: PSBA2_SYNY3
Sequence: MTTTLQQRESASLWEQFCQWVTSTNNRIYVGWFGTLMIPTLLTATTCFIIAFIAAPPVDIDGIREPVAGSLLYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPYQLVVFHFLIGIFCYMGRQWELSYRLGMRPWICVAYSAPVSAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLVRETTEVESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLGAWPVIGIWFTAMGVSTMAFNLNGFNFNQSILDSQGRVIGTWADVLNRANIGFEVMHERNAHNFPLDLASGEQAPVALTAPAVNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1 2, PSII D1 protein 2, Photosystem II Q(B) protein 2.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: ESIP1_RAT
Sequence: MYPRSRVVGPGLGTSSSSRDHAGAGQHGELDLQQNQRQNLEVAEPKGPKLERQGHGDQRSTGTYTLIAPNETRRQKIQRIAEQELADLERWKQQNKAKPVHLVPQRLGGSQSEAEVRQKQQLQQMRSKYQQKLKRDEAIRIRKDAEEAELQRMKAIQREKSNKLEKKKQLQEDIRRATLREHHQSKTAELLSRLDTDRTNRSACNIAPPAAQSSRWKLPVLLRDPSRAGSQAHKDSPQKEDNQKLQKTRDGHQKNKLLETKGQHQEEERAQIHQAEHWRVNNAFLDRLQGKSQPGGVEQSGGCWNMNSTDGWGI
What is the function of this protein?
Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity).  Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity).
What are the official names of this protein?
Epithelial-stromal interaction protein 1.
Protein: PGK_PENCH
Sequence: MSLSNKLPVTDVDLKGKRVLIRVDFNVPLDENENVTNPQRIVGALPTIKYAIDNGRKAVVLMSHLGRPDGKVNPKYSLKPVVPVLEELLGKSVTFTEDCIGPQTEETVNKASDGQVILLENLRFHAEEEGSSKDAEGKKVKADKADVDRSASLTALGDVYVNDAFGTAQRAHSSMVGVDLPQKAAGFLVKKELEYFAKALESPARPFLAILGGAKVSDKIPVIDNLLPKVNSLIIIGGMALTFKKTLENVKIGNSLFDEAGSKILGEIVEKAKKHNVEIVLPVDYVTADKFSADATVGSATTQRIPDGYMGSDVGPESVKLYQKTIAEAKTILWNGPPGVFELKPSPRPTEATLDAAVKAAESGSIVIIGGGDTATVAAKYKAEDKISHVSTGGGASLELLEGKELPGVAALSSK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARF1_LOCMI
Sequence: MGNVFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIGEAREELMRMLAEDELRDAVLLIFANKQDLPNAMNAAEITDKLGLHSLRNRNWYIQATCATSGDGLYEGLDWLSNQLKNANR
What is the function of this protein?
Small GTPase involved in protein trafficking between different compartments.  Modulates vesicle budding and uncoating within the Golgi complex.  In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane.  The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
What are the official names of this protein?
ADP-ribosylation factor 1, lARF1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: BAMA_SERP5
Sequence: MAMKKLLIASLLFGSATVYGADGFVVKDIHFEGLQRVAVGAALLNMPVRVGDTVTDDDISNTIRALFATGNFEDVRVLRDGNTLIVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGEALDRTTISSIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFTEGVSAKIQQINIVGNHAFTNDELISRFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSFYLDRGYARFNIDSTQVSLTPDKKGIYITINITEGEQYKLTDVVVNGNLAGHSAEVAQLTKIEPGELYNGSKVTKMEDNIKTMLGRYGYAYPRVSTQPEINDADKTVKLHVNIDAGNRFYVRRIKFEGNDTSKDSVLRREMRQMEGAWLGNAQVEQGKERLNRLGYFETVDVETQRVPGTADQVDVTYKVKERNTGTFNFGVGYGTESGVSFQAGVQQDNWLGTGYSVGISGTKNDYQTYTELSVTNPYFTVDGVSLGGRIFYNDFKADDADLSDYTNKSYGIDGTLGFPINENNSLRTGLGYVHNGLSNMQPQIAMWRYLDSMGLNPNTTDRASYSADDFTLNLGWTYNNLDRGYFPTSGNRTTLNGKVTIPGSDNEYYKLTLDSVQYVPINDDRTWVLLGRGRLGYADGLGGKEMPFYENFYAGGSSTVRGFGSNTIGPKAAYYNSNSYGCSNGTPICNSDDAVGGNAMAVASMELITPTPFISEKYANSVRTSLFMDAGTVWDTNWQNTAQTSMYDIPDYSKASNIRVSAGIALQWMSPLGPLVFSYANPIKKYEGDKSEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: LUXS_SERP5
Sequence: MPLLDSFTVDHTRMAAPAVRVAKTMKTPHGDTITVFDLRFCRPNLEVMPERGIHTLEHLFAGFMRDHLNGQGVEIIDISPMGCRTGFYMSLIGVPEEQRVADAWKAAMSDVLKVTDQRKIPELNEFQCGTYHMHSLEEAQEIAKHILDHDVVVNHNEELALPKEKLQELHI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: ILVC2_STRCO
Sequence: MAELFYDADADLSIIQGRKVAVIGYGSQGHAHALSLRDSGVDVRVGLHEGSKSKAKAEEQGLRVVPVAEAAAEADVIMILVPDPIQAEVYEKDIKDNLKDGDALFFGHGLNIRYGFVKPPAGVDVCMVAPKGPGHLVRRQYEEGRGVPCLVAVEQDATGNAFALALSYAKGIGGTRAGVIRTTFTEETETDLFGEQAVLAGGVTALVKAGFETLTEAGYQPEIAYFECLHELKLIVDLMYEGGLEKMRWSISETAEWGDYVTGPRIITDVTKAEMRKVLAEIQDGTFAKNWMDEYHGGLKKYNEYKKQDSEHLLETTGKELRKLMSWVDEEA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)) 2, KARI 2, Acetohydroxy-acid isomeroreductase 2, AHIR 2, Alpha-keto-beta-hydroxylacyl reductoisomerase 2, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: TILS_CORDI
Sequence: MHKFWPRHSPNFMACRVAVRTVQPRDITVGLSGGADSLALVAALCAEDYNVHALCVDHGLQPGSHEVAQQAAHHARTFGAHAEIISVTVAPGNLEANARTARYQALHSRNLPVVVGHTADDQAETLLLGALRGKATGMQIHTDNLWRPLLGVRRATTLAACTELGIEPWHDPHNANTDFLRVALRTQVVPLLSDIIGGDAVPALSQAATLIAEDTHALHVDTPDDRIAQLAGMPPALRRRHLVALLQAYGARVSAAHLRAVDALITNWHGQKAVPVGNGLEVTRKDGRLSVS
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLCN7_MOUSE
Sequence: MANVSKKVSWSGRDRDDEEGAPLLRRTGQPDEETPLLNGAGPGARQSHSALFRIGQMNNVELDDELLDPEVDPPHTFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFNALNYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPMTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILRSQLIVLLKHKVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNHNQVVGLVTRKDLARYRLGKGGLEELSLAQT
What is the function of this protein?
Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:16525474, PubMed:19661288).  Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:16525474, PubMed:19661288).  The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity).  The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity).
What are the official names of this protein?
H(+)/Cl(-) exchange transporter 7, Chloride channel 7 alpha subunit, Chloride channel protein 7, ClC-7.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClC-7/CLCN7 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: E51_SSV1
Sequence: MIEKRKDRIVKRLNISISEETYETLQRLKAKTGKTMGQLIEEAVKLLEAEE
What is the function of this protein?
This protein is non-essential for virus function.
What are the official names of this protein?
Uncharacterized protein E-51.
Protein: T23O_BORPA
Sequence: MQPTPTQRPEAIVHDEKAQLDFARDMSYGDYLHLDELLGAQRPLSPEHNEMLFIVQHQTSELWMKLMLHELRAAIAAIQQDRLQPAFKMLARVSKILEQLVSAWDVLATMTPPEYSALRPYLAHSSGFQSYQYRQIEYLLGNKNAAMLQPHAHRADLLAQVRAAFEAPSLYDEALRFLARSGLAVPAGALQRDWTQPYRADDQVEQAWLTVYRQSERYWNQYQLGEKLTDLEDAFRLWRFRHVTTVERIIGFKRGTGGTSGVTYLRKMLEVVLFPEIWKLRTDL
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: KCY1_ARATH
Sequence: METPIDAPNKDEHECPRWKKSTVVFVLGGPGSGKGTQCANVVKHFSYTHFSAGDLLRAEIKSGSEFGAMIQSMIAEGRIVPSEITVKLLCKAMEESGNDKFLIDGFPRNEENRNVFENVARIEPAFVLFFDCPEEELERRIMSRNQGREDDNIETIKKRFKVFVESTLPIISYYESKGKLRKINAAKSSEEVFEAVRVLFASET
What is the function of this protein?
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP.  Plays an important role in de novo pyrimidine nucleotide biosynthesis.  Has preference for UMP and CMP as phosphate acceptors.
What are the official names of this protein?
Probable UMP-CMP kinase 1, Deoxycytidylate kinase, CK, dCMP kinase, Uridine monophosphate/cytidine monophosphate kinase, UMP/CMP kinase, UMP/CMPK.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PTHP_LYSSH
Sequence: MKTQQFTVIDPLGIHARPASQLVAKATPFASAIEVRTEEKAANLKSILGVMGLALKQGSQFTLYVEGEDEDQAFEALATLLTEMGLAQ
What is the function of this protein?
P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes.  Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources.  P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity (By similarity).
What are the official names of this protein?
Phosphocarrier protein HPr, Histidine-containing protein.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTBD_BACSU
Sequence: MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPVTTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILLAARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQFGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITALGYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALFYMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVDVASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRDRQEA
What are the official names of this protein?
Uncharacterized MFS-type transporter YtbD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THIE_MYCPA
Sequence: MHQRLATLAAARLYLCTDARRERGDLAEFADAALAGGVDVIQLRDKGSPGEQRFGPLEARDELAACEILADAARRHGALFAVNDRADIARAAGADVLHLGQGDLPLEVARAFVGPDVLLGLSSHDRDQMAAAAAGPADYFCVGPCWPTPTKPGRAAPGLALVRAAAELHTGKPWFAIGGIDAQRLPEVLDAGARRVVVVRAITAADDPAAAARRLSSALAAAR
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: DNAJ_BURM9
Sequence: MAKRDYYEVLGVAKNASDDEIKKAYRKLAMKYHPDRNPDSKDAEEHFKEAKEAYEMLSDGQKRAAYDQYGHAGVDPNVGAAGAQGFGGFADAFGDIFGDIFGQAAGGGRARGGPQVYRGADLRYSMEITLEQAAHGYDTQIRVPSWAACGVCHGSGAKPGTKPETCPTCHGQGTVRMSQGFFSIQQTCPKCHGTGTYIPEPCAHCHGSGKVKETKTLEVKIPAGIDDGMRIRSAGNGEPGINGGPSGDLYVEIHIKPHAVFERDGDDLHCQMPIPFTTAALGGEIEVPTLAGRASFTVPEGTQSGKTFRLRGKGIKGLHSSIAGDLYVHVQVETPVKLTDQQRDLLKQFEKSLAEGGPRHSPQSKSWFDRVKSFFE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANMK_RUEPO
Sequence: MTALGAMSGTSLDGVDAAVVETDGLAIFGFGPVGYRAYSPEERAVLRAGLGRWAGPEVEAAGDLVTRAHAQALAGFEGVDLVGFHGQTLAHEPRGRGTLQVGDGAALAAALRRPVVWDFRSDDVQLGGEGAPLAPFFHFACAKWIGATEPLCFLNLGGVGNLTYVDPSFERPEVPGALLAFDTGPANAPVNDLMQARLGLPMDEGGAVARGGTVETGALELFLAEPYFSRMPPKSLDRNDFAEMIGLVSELSDSDAVATLTGMCAAAVAQGMEHCPRPPARVLVTGGGRHNPVLMEMLQVSLDCAVEPVECVGLDGDMLEAQAFAYLAVRVARGLSTSCPGTTGVGALVGGGMVSLPDEA
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: PPR3B_DANRE
Sequence: MPIELAMSLYLSSDEFLNPRASKYSRPLQPCLNQCKSSKLSFSSLKEQSEFNGVSRALMIPGRAKKHVSFADHKGLALTVVKIFSEFDDPIDIPDNIDNFFTSSLTVSEGKDKLTLDFDQPSADYLKFRQRIENDHVCLEHCMLKEKSIMGTVKVKNISFEKSVKLRITFNTWKNHTDVECQYVKDTYTGSNRDTFSFEASLPEQVPSHERIEFAICYEVNGDTLWDNNQGKNYRIIQSALRKSSNESNGGHQQYSQSDWDIHFDRYGSPRCSRGIFPHWPSYVGYEDIGPYY
What is the function of this protein?
Acts as a glycogen-targeting subunit for phosphatase PP1.  Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity.  Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown (By similarity).
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 3B.
Protein: HYEP_CITBB
Sequence: MDISFQIQDAVASVIRAPLASPFRIATGQHDELENVFLKLTTRDGVSGYGEAAVASHITGETVPGTLANLQNAAAALRGQTVDDAESACRQFAAAFAGNHAGLAALEMALLDLSSRVRGIPFYRLFAPVAALEPRLAFSTDITVVIGSLDEARATAREFASRGFKAFKIKIGRDEQLDLARVLAVHEIAPDSQIILDANMGFSAGSMLAFLDRLAAKGVRPVLLEQPVPKMDWDGLSEITAALTGSETLVCADESVGSLADARRAIDSNAVSAINVKFMKSGILEGAEIARLAASRGIRLMLGAMMESALAVTASAHFAAGLACFDYLDMDTTFFLKGELAHSPYLDEHGRFDLHDAGPGIGVEPRFS
What is the function of this protein?
Catalyzes the epimerization of various hydrophobic dipeptides, such as L-Ala-L-Phe.  Has epimerase activity with L-Ala-L-Thr, L-Ala-L-Met, L-Ala-L-Tyr, as well as L-Phe-L-Met, L-Phe-L-Ser and L-Phe-L-Thr (in vitro).
What are the official names of this protein?
Hydrophobic dipeptide epimerase, L-Hydrophobic-D/L-Hydrophobic epimerase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family.
Protein: ISM1_DANRE
Sequence: MVRLAAELLLLLGLLLLTLHITVLRSSPLQHGNDTVSLEQDSRVAENNVNADSSSSVQLGPGDRQTRVAHIPASQPWAQSPGTGGSLQRDGPGAFLLDLQNFPDLSKADINGQNPNIQVTIEVVDSLEGSEPEKGMRKENKPGWAAPNWRNWWQRSSSSSSSSVSTPKGPEEQDYPYESNTEDSNFLKPLGDWERRVKSEAGAGSRTQTEYDYIDGEGDWSAWSPCSVSCGNGNQKRTRSCGYACTATESRTCDMPSCPGIEDAFKTAATEVSLLAGTEEFNATELFGVDTDSCERWMNCKSEFLKKYMSKVATDLPSCPCFYPTEVAYSTADVHDANTKRNFRWKDASGPKEKLEIYKPTARYCIRSMLTLESTTLAAQHCCYDDSMKLITRGKGAGTPNLISTEFSADLHYKVDILPWIICKGDWSRYNHARPPNNGQKCAENPQDEDYYKQFEEAREF
What is the function of this protein?
May specifically influence certain angiogenesis process (PubMed:19874420).
What are the official names of this protein?
Isthmin-1.
What is the protein family that this protein belongs to?
Belongs to the isthmin family.
What are the subcellular locations of this protein?
Secreted.
Protein: EFP_THEYD
Sequence: MISTSEFKKGLKIEYKGEPYEIIDFQHVKMQQRAPIVRTKIKHLKTGRVLEENFPAGEKFEKPELEEKQMQYLYSQGDSYVFMDMESYEQISIPKERIGDAIYYIKDEMIVDVIYYKGEPLVIEPPMFVELRVAETEPAFKGDTASGGTKPAKLETGLTVKVPFHIQTGDLLKIDTRTGEYIEKVKE
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_ACTP2
Sequence: MPRSLKKGPFLDLHLLKKVEKAVESGDKKPIKTWSRRSMIIPSMIGLTIAVHNGRQHVPVYVSDEMIGHKLGEFAPTRTYRGHAADKKAKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.