PharMolix/UniProtQA huggingface dataset:
Protein: CTTB2_OTOGA
Sequence: MATDGASCEPDSSRAPEDPAGATAEAPKKEFDVDTLSKTELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCRKMQERMATQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLLLVKECKQLSGRVIEEAQRLEEVMAKLEEEKKRTSELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLSREEAHTTDLKEEVDKMKKMIEQLKRGGDGKPSLSLPRKTKDRRLVSASVGTEGPLTRSVACQTDLAVESAEPVKKSPLTVHVKPSPGSPHVSVKGSGGKPGMDRQASHGELMGSALPTLPPPSASRIEENGPSPGSTPDAPGSAAPPGSAAPPGSAAPPGSAAPPGSAAPHSFHSPCASAPPHPGLNPRIQAARFRFQGNANDPDQNGNTTPSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPPAGAAPRPGASPTGDGGAYPPVGRTGLKTPGVARVDRGNPPPIPPKKPGLSQTPSPPHPQLKVIMDSSRASNAGAKVDNKTVASPPSSLPQGSRVINEENLPKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAETPGLNHPACSDSSLVIPTTTASRSAINPVSASSCSPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLNAEAQVNAADKNGFTPLCAAAAQGHFECVELLIAYDAHINHAADEGQTPLYLACKNGNKECIKLLLEAGTNRNVKTRDGWTPVHAVVDTGDVDSLKLLMYHRAPARGNSLNEEEPKSDIFDLDEGEESPEGISKPVIPADLINYANREGWTAAHIAASKGFKNCLEILCRHRGLEPEKRDKCNRTVHDVATDDCKHLLENLNALKIPVRISVGEIQPGNYGSNDFECENTICALHIRKQTSWDDFSKAVSQALTNHFQAISSDGWWSLEDTALNDTADSNIGLSTSSVRAIMLGHVPWSSGQSFTQSPWDFMKRNKVEQVTVLLSGPQEGCLSSVTYASMIPLHMLQNYLRLIEQYRNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVTAEVDAGFSKEQLVDLFISSACLIPVKQSPVKKKIIIIILENLEKSSLSELLGDFLAPLENRSTESPCTVQKGNGMSACYYFHENCFLMGTIAKACLQGSELLVQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFRGQVPSPCDLVCKTVAWALSVWRQLNSCLARLGTPEALLGPKYFLSCPVIPGHAQATVKWMSKLWNAVIAPRVQEAILSRASMKRQPGFGQTTAKKHPSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPLSLVSSYNSCSKKKESGAWRKVNTSPRRKSGRFSSPTWNKADPSSEGLKNKTISQLNCNKNASLSKQKSLENDLSLMLNLDQRLSLGSDDEVDLVKELQSMCSSKSESDISKIADSRDDLRTFDSSGNNPAFSATVNNPRMPVSQKEVSPLSSHQTTECSNNSKSKPESGVSRAKSFLPVPRSKATQCSQNTKRSSSSSNTRQIEINNNSKEENWNLHKNEQIEKPNK
What is the function of this protein?
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
What are the official names of this protein?
Cortactin-binding protein 2, CortBP2.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cell projection, dendritic spine. Note=Remains associated with dendritic spines even after glutamate stimulation.
Protein: Y785_RICPR
Sequence: MLKKYLLFCLFLFFSFNVYASIWDDIITCLSDPCNCGQSDRTEIWNKGSKYEVKRGPFKPGTLCPPWNKSDGRNNDTCLLQFDYPGTFIGFLLNRCAEEAPDSSYFTPKIRIRVQSCNAAACWHQNSTLNWDGECVLWPTGYGLPLTRVCARVAIPEMNSPSGINASHSYADPGYTEGVHLNKVGYTESDNKIIGVDGQVVTLKSPKLCAYSDPGLVNLISDSGIHLDPMDWNPNRQPLHQTNELSPIAKVLKFLVETVKGFSLPSLLGQLLGMIDPNSEFIKVLQSILNAIGEVFNFFPDLIIKVIEKLGALNSAVDSYSFGCVQLPLGPFPPPYCPNLNAISINPSVNNVCSIKNASGIFDQSSTSPSCVVPSNINVRNNIVNNTIRVSFSNLVPLCTGAKPDLKTCVELRNIDFSSAKITHTKTAFKDLIKSCKNTSGNAACINTEIPTPCSVTANGCNEGFRIVYSQKIGNIETPRDYYIDDIPDCPSSNSTTCQKVWGVNIGEFKDVSIKFPKVQKQDTNSLIPIKTDFTLKDNNGKDRKLYVSISNTEDDKQNPNNICLFESANLIDCVPRVNHSYSLAAYECAKQYAGITCTNNSNPNDAYYKPQFIASLQVREGSNIIDETSTLVTPLSYAGPPPQNPTDTESIVMLAGYQYSSSVAFIPKNPIKDKYIGMPFSGPNALNQLTIHGKYKDDKEPYDSKGNPDLSAIYLKYLEYINGKYIQGGTHACLMPKNFQHCNPMPRPTLSDGAPIPGYNNESINCVLAKVHNNDTINCKDFKNKYNAKYPNLGLCKKDIDLTLCTIEETVPGPRKGITIYTCNINKIPSKCYTNNDNANTPICVLSRDYKDRIKPEPSIGPILVPVDPSKYYTVTYTKGDENTPPEPTYHAETEDVRDKTWQELNLCAPILVPTCAKIPSTAEAPSGQSHGNAEWPESDIGELVKGKCPTNWILIDPNKPLERHCLSYFDRKVVELEPLGHNVGCRKSTGLPIQVVYNDFPSNQLPDTPYNPVTKIGDYFLNKKPVRYGTIMAFPKDGAFINASNEPDNTILHTVVFKVTLDAIMDDIEYFIVEDLWYDDCTLIYVNGTKLLSLPTNVDSLDEKRYCNNGKDQGQALQAKVNNQRISAKNPIDIKPYLKQGENIIKFQLRVMSGGGLYFHMQYKMKR
What are the official names of this protein?
Uncharacterized protein RP785.
Protein: MURA_SINMW
Sequence: MDRIRIVGGNELHGVIPISGAKNAALPLMIASLLTDDTLTLENVPHLADVEQLIRILGNHGADISVNGRRERQGESYARTVHFTSRNIVSTTAPYELVSKMRASFWVIGPLLAREGRARVSLPGGCAIGTRPVDLFIEGLTALGASIEIDGGYVNATAPAGGLIGGRYTFPKVSVGATHVLMMAATLANGTTVLGNAAREPEVVDLAKCLNAMGAKISGQGTSTITIEGVRSLSGARHRVLPDRIETGTYAMAVAMAGGDVILEDTEASLLDTALEAIRRAGAEISDTNNGIRIVRNGAGIRPVDIVTDPFPGFPTDLQAQFMGLMTRSSGVSHITETIFENRFMHVQELARLGAKISLSGQTAKVEGVSRLKGAPVMATDLRASVSLVIAGLAAEGETMVSRVYHLDRGFERLEEKLTRCGAHVERVSD
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_ANAD2
Sequence: MIARLAGRIAEKRDDHAIVDVGGVGYLVHLSQLSLASLPPPGEPAALRVYTHVREDALDLYGFATEDEEAVFRALIDVKGVGPRAAQNILSGIEARELAQAVAQGDVARLTKVQGIGKKTAERLVLELKEKLVALARAAGPARAGAEADVLEQLRTALLNLGYRPPQAEGVAEALRDSAEGRPLDELLREALKLLRG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: MTL26_DANRE
Sequence: MLNAAAADRNKDPILSVLKSRVASNRRLFALEISSGTGQHVVHFAKAFPNITWQPSEVETQSLSSIEAYRQYHRLQNVQPPIYLDVSQSWQTWGGFPAESCDLIININMMHISPLACTTGLFHGVGQILKPQGLLLTYGPYAFNGSIVPQSNFDFDQSLRYRNPEWGLRDASFLTTLGQENGLRLEEIVDMPANNKCLLFRKDSVV
What are the official names of this protein?
Methyltransferase-like 26.
What is the protein family that this protein belongs to?
Belongs to the UPF0585 family.
Protein: RUTB_METRJ
Sequence: MDRPTTYPMDQPAGFRDAQGRHGGVVLPARPEPIALDPATTFLIVVDVQNAYASPGGYLDRAGFDVSGTGPVIARIARAVAAARAAGIPVLWFQNGWDPAYVEAGGPGSPNWHKSNALKTMRRNPEANTQLLAKGSWDYALVDALTPEPGDIVMGKPRYSGFYNTPLDSTLRARGVTTLVFTGIATNVCVESTLRDGFHREYFGIVLADATHQAGPESLHRAALANIETFFGWVSDVAAFESALGVPSRAPAGADLAG
What is the function of this protein?
Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate.  The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.
What are the official names of this protein?
Ureidoacrylate amidohydrolase RutB.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family. RutB subfamily.
Protein: ATPD_STRT1
Sequence: MDKKTQALVGQYARSLVEVAFEQDAVSTIQEEVRQILTVFAETNLKTFLSQVNVTSEAKKESLSFFQESCSVYMNNFLEVISLNDRANILYDVLKLVLELFDQEDNTYDVTVTSASPLSEEQKTRLLTIVSQKFEIKTRRLVEKIDEELIGGFVIKAKNKFVDTSIRSQLQAFKMNLK
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HIS1_THEON
Sequence: MRFVLPKGRLFKGSLEILKKAGIELKPPETRELIVRNGRYELLLARAFDVPVYVEHGIDVGIAGSDVVEERGSDVLVPLELPFGKCRLSLAMPKESAVSVEEMDGFRIATKYPNLARKFFERNGVEVEVIKLHGSIELAPKIGVADAIVDIVETGNTLRANGLVEVEKIMDVSALLLVNRISQKTKFDEINELVLKIKEVVRDGF
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_VIBCM
Sequence: MAAPGEALTPSSYITHHLTNLSTYKLGLVAEESSFWNVHIDSLFFSVLTGLIFLGVFRAVARKATAGVPGKLQCAVEMVVEFVDKNVKDTFHGRNPLIAPLALTIFCWVFLMNLMDLVPIDFLPYPAQHWLGIPYLKVVPSADVNITMAMALGVFALMIYYSIKVKGLGGFAKELALHPFNHWIMIPFNLLIEVVSLLAKPLSLGMRLFGNMFAGEVVFILCAAMLPWYLQWMGSLPWAIFHILVILIQSFVFMMLTIVYMSMAHEDNDH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: R144B_BOVIN
Sequence: MGSVGRLHCLTMTAAENPTPGDLALVPLVTCKLCLCEQSLDKMTTLQECRCIFCTACLKQYMQLAIREGCGSPITCPDMVCLNHGTLQEAEIACLVPVDQFQLYQRLKFEREVHLDPCRTWCPVADCQTVCPVATSDPGQPVLVECPSCHLKFCSCCKDAWHAEVSCRDSQPGILPTEHGTLFGTETDAPIKQCPVCRVYIERNEGCAQMMCKNCKHTFCWYCLQNLDNDIFLRHYDRGPCRNKLGHSRASVMWNRTQVVGILVGLGIIALVTSPLLLLASPCIICCVCKSCRGKKKKHDPSTT
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation.  Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism.  However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF144B, RING finger protein 144B.
What is the protein family that this protein belongs to?
Belongs to the RBR family. RNF144 subfamily.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Protein: KAD6_PYRFU
Sequence: MIIAITGTPGVGKTTVARKLAEKLGCKYVNLRDFALEKGIGEVKGDELEVEVDELAYFVEKEFKGKNVVLDGHLSHLMPADLVIVLRAHPKTIAERLKERGYSKDKIGENVEAELVDVILIEALDEHENVIEVDTTGKTPEEVVNEILNLINSGIKRRVGIVDWTKVYEEIIPYLRLGGD
What is the function of this protein?
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
What are the official names of this protein?
Putative adenylate kinase, AK, ATP-AMP transphosphorylase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK6 subfamily.
Protein: EFTS_SHESR
Sequence: MAISAAQVKELRERTGAGMMDCKKALEETNGDMELAIDNMRKSGAAKAAKKAGNIAADGTILIKNGEGFAVLLEVNCQTDFVAKDANFLGFANAVLDVAAASKVSLEDLKAQFEEARVALVAKIGENINVRRVEYIDGTQLASYRHGERIGVVVTGEADEETLKHLAMHVAASKPEYVNPEDVPADVVAREQALQIEISMNEGKPAEIAEKMVVGRMKKFTGEISLTGQAYIMEPKKTVGEFLKEKGAKVTNFIRLEVGEGIEKKEEDFAAEVAAQIAASKKA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSI_BAUCH
Sequence: MNKKIPKAILSDNERLKVASNFLRGTIAQDLQDNITGGFKGDNIQLIRFHGMYQQDDRDLRVERTCQKLEPLINMMLRCRLPGGIITPQQWLGIDSFATKHTLYGSIRLTTRQTFQFHGVLKPNLKNMHKLLHSLGLDSIATAGDMNRNVLCTSNPVESVLHQQVCNYAKMISEHFLPKTRAYAEIWLDGEKTETTEQEPILGANYLPRKFKISIVVPPLNDVDLHANDLNFIAISNLGQLVGFNVLVGGGLAMTHNDKSTYPRTASELGYISVVDTIKIAEAVITTQRDLGDRSNRKHAKTKYTIERVGVEFFKKEVEVRAGIKFKHIRPYSFTERGDRFGWVQGIDNQWHLTLFIENGRIIDDSHRKLKTGMLEIARIHQGDFRITANQNIIIAGVEKKHKATIELLARQYGLINNNITLQRKASMACVAFPTCPLAMAEAERFLPQFVTKVENIMSRHGLGQEKIILRVTGCPNGCGRAMLAEIGLVGKTIGRYNLYLGGDSIGTRIPRIYRENLTEEEILSIINDTTGRWARERQPDESYGDYVVRAGIIRPVINSALDFHN
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: PTH_CERS4
Sequence: MKLFVGLGNPGARYAGNRHNIGYMAVEAIAADHGFGPWRARFQGLTSEGRLGSEQVLLLKPETFMNLSGQSVGEAMRFYKLTPADVIVFHDELDLAPGKLRLKQGGGHAGHNGLRSIHAHVGEAYGRVRLGIGHPGHKDAVAPYVLSDFAKADQDWLADLLRGISDGAEALARGDGAKFQNAVALRMQPPKPEKPKPAAKAPEAQAPEAAPDERSALQKLADRFR
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALLC_NOCFA
Sequence: MNETAADRVAPRGFTELPDLAVRSLGGAVIWADDEFFAEKENLIVPEAPEFRPATYGHRGQVYDGWETRRHRGLPGDDAAVVRLGVPGVIHGVVVDTSWFTGNYPPAISLSALAIDGYPPAADIAARTDWVPLLDRVPVRGDARNPFPIPSRDRWTHVRLTMHPDGGIARLRVHGEGRPDPALLGLGPVDLAALENGALVLDCSDRFYGSPHQLLHPGNARRMGDGWETARRRDDGNDWVRIRLAGPGLIRLAELDTSYFLGNSPAAARLTGRTTDGTEVELLPRTPLQPDTRHRFPTAAVAASVEEVRLDIYPDGGLARVRLFGELGG
What are the official names of this protein?
Probable allantoicase, Allantoate amidinohydrolase.
What is the protein family that this protein belongs to?
Belongs to the allantoicase family.
Protein: SAS6_DROME
Sequence: MWPPGSEDSYSAKMDYGKSVVNILPSVEMLVNFNGEMTRSSKRSCLLYAERVDFKELLQLRLTEKSDQRRMYITTVDSASFQDLKQDQSLNVSFSGFIDNVVRMLKDCQSGKLELHLTTRDQNLSSGREVHDYYLQFVEIRSFKNLVHLSLPCRSAPLNTVLFYINSMLEASHKKQYILEQSMQQMQAEINAQRAHAERLTTENTNIREALAENTRILEEKHAAEVHQYQEKLSKINEQRSNELERNRRAISGFQAQLDKASLEKAELKSAQEQAEKRCQTLSEELSCCKARVCTLKEQNDKLHGDVANIRKHERKLEYKIEDLKQHTVELQEHIQKGNKEKANIAAELEAEKKILHTKRQALEMASEEISKANQIIVKQSQELLNLKKTIAWRTEVALQQEKAVQAKESLLSLRENELREARITIEKLREEIPQQLQSMRNFAQGLEQKYSKQILILKERLAIPTGKENRR
What is the function of this protein?
Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:17412918, PubMed:17463247, PubMed:30013109).  Required for centrosome biogenesis and duplication (PubMed:17412918, PubMed:17463247, PubMed:30013109, PubMed:33704067).  In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function (PubMed:30013109).  Required for sperm cilium basal body elongation together with Cep135 and Ana2 (PubMed:30013109).
What are the official names of this protein?
Spindle assembly abnormal protein 6 homolog.
Protein: FUC2_RAT
Sequence: ELPGLPKGEKEQQEAIEHIDEV
What is the function of this protein?
Has a role in the physiological regulation of fucosylation processes.
What are the official names of this protein?
Fuctinin-2, Fucosyltransferase inhibitor 2.
What is the protein family that this protein belongs to?
To human SET/PHAPII protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIT_ECOK1
Sequence: MNNAPHLYFAWQQLVEKSQLMLRLATEEQWDELIASEMAYVNAVQEIAHLTEEVAPSTTMQEQLRPMLHLILDNESKVKQLLQIRMDELAKLVGQSSVQKSVLSAYGDQGGFVLAPQDNLF
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TF2B_BOVIN
Sequence: MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAEAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKFDTPVDKLPQL
What is the function of this protein?
General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II).  Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA.  Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex.  Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle.  Associates with chromatin to core promoter-specific regions.  Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element.  Modulates transcription start site selection.  Exhibits also autoacetyltransferase activity that contributes to the activated transcription.
What are the official names of this protein?
Transcription initiation factor IIB, General transcription factor TFIIB.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis. Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle.
Protein: ENGB_BRUA2
Sequence: MSEQDKKQAAIKAAQAAADAVREAQAALAEEGRLLFKKSWIFIRGVPSMKFLPPEGPVEIAFAGRSNVGKSSLINALVGKKGLARTSNTPGRTQELNYFVPDGYSGENGDLPPLALVDMPGYGFAEAPKAQVDAWTRLVFDYLRGRTTLKRVYVLIDARHGIKKNDAEVLDLLDKAAVSYQIVLTKIDKIKPAGVPRLLEETHKLTYKRAACFPGIIATSSEKGQGLDDLRAAIALLLKEY
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: PG078_MONPV
Sequence: MDKLYAAIFGVFMGSQEDDLTDFIEIVKSVLSDEKTVTSTNNTGCWGWYWLIIIFFIVLILLLLIYLYLKVVW
What is the function of this protein?
Late protein which probably plays a role in virus entry into the host cell.
What are the official names of this protein?
Protein OPG078.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG078 family.
Protein: BIOP_ECO57
Sequence: MALLIITTILWAFSFSFYGEYLAGHVDSYFAVLVRVGLAALVFLPFLRTRGNSLKTVGLYMLVGAMQLGVMYMLSFRAYLYLTVSELLLFTVLTPLYITLIYDIMSKRRLRWGYAFSALLAVIGAGIIRYDQVTDHFWTGLLLVQLSNITFAIGMVGYKRLMETRPMPQHNAFAWFYLGAFLVAVIAWFLLGNAQKMPQTTLQWGILVFLGVVASGIGYFMWNYGATQVDAGTLGIMNNMHVPAGLLVNLAIWHQQPHWPTFITGALVILASLWVHRKWVAPRSSQTADDRRRDCALSE
What is the function of this protein?
Uptake of biotin.
What are the official names of this protein?
Biotin transporter.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BIOD_ANASK
Sequence: MRGLFVTGTDTGVGKTEVSCALLRAARAAGLDAVGMKPAQSGHVPGEPSDAERLREASDCVEPLEAICPYTFAAPLAPAAAARLEGREVSLARVVEVARALAARHAAVVVEGAGGLLVPLTARETHADLAAALGLPVLVVARAGLGTVNHTALTVEALERRGLAVAGIVLNRTGPEDDPSVPLNPAEIARLTHREPIALLPWEPDIARRARSLGSILGAKIQF
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_MYCPN
Sequence: MKLRATFVFKTTLVALSFALFALFLVSCTENVKEIKSESVINELFPNLWVFLAHLLAFVILLFLLLFLFWKPTQKFLNQRKALLEEQVNQANSLEQQAQALLQQANQRHENSLVVAKEIVDQANYEALQLKSEIEKKANRQANLMIFQARQEIEKEKRLIQEQSLKESVELAMLAAKELIIKKVDVKADKAFIEEFIRELEAEDDHD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: OPAF_ASPUT
Sequence: MARGAAELTQTRKVMIKEQLANLTALIDLRIADTPCNGLDDDMPMQPAIDNTITHELAKETYALLHAIKGPSLSVFNFGEQVMHVSAVRALFGLGVFSALPQDRQAMTATALAEKLGCDEELLVRLMRMCTIWGPFKEVGTETYSHTQFSLAYLDPQVTNQFQAFVDEFLPACLQLHKFLEINNGKPPVDATNCPYTLAHQTSGKDMWEHLAQFPKRSKVVNSAMYAISSAHPWPVALYPFREALLQLPPTSSNAPLVIDIGGGQGQAISVIRKMCGGINGRFILEDRPEVLAGIPHTLRGIEKIECDLFKPQPVKGAAIYFLRHVLHDWAEDACVRILQNIASAITDKSTQRVVISEMVLPEKGVTAECATQDLVTLSTTGAERSRKQWERLIPAAGFRVENIYSSEASCEAAIECYLE
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of oxepinamides, derivatives of anthranilyl-containing tripeptides that share an oxepin ring and a fused pyrimidinone moiety (PubMed:33004788).  The nonribosomal peptide synthetase (NRPS) opaA assembles the quinazolinone core with D-Phe incorporation (PubMed:33004788).  The first adenylation domain (A1) of opaA loads and activates anthranilic acid whereas the second A domain (A2) is for activating of L-Phe, which is then converted to D-form by the E domain (PubMed:33004788).  The third A domain (A3) is responsible for L-Ile activation and the terminal condensation domain C3 for cyclization and releasing the NRPS product protuboxepin K (PubMed:33004788).  The cytochrome P450 monooxygenase opaB then catalyzes alone the oxepin ring formation to convert protuboxepin K into protuboxepin A (PubMed:33004788).  The flavoenzyme opaC installs subsequently one hydroxyl group at the oxepin ring, accompanied by double bond migration, to form 15-epi-oxepinamide E (PubMed:33004788).  The epimerase opaE changes the D-Phe residue back to L-form, leading to oxepinamide E, which is further methylated at the hydroxyl group at C-12 by the O-methyltransferase OpaF to yield oxepinamide F (PubMed:33004788).
What are the official names of this protein?
O-methyltransferase opaF, Oxepinamide F biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: FEOC_YERPN
Sequence: MASLLQLRDAIALNGSAEASQLSRQLAIPLPLVNAMLEKLTAMGKIERIELDHSGCLTGSCKSCPEGHQHCNTVIYQLKEPHAHQ
What is the function of this protein?
May function as a transcriptional regulator that controls feoABC expression.
What are the official names of this protein?
Probable [Fe-S]-dependent transcriptional repressor.
What is the protein family that this protein belongs to?
Belongs to the FeoC family.