PharMolix/UniProtQA huggingface dataset:
Protein: FRSA_ECO81
Sequence: MTQANLSETLFKPRFKHPETSTLVRRFSHGAQLPVQSALDGKTIPHWYRMINRLMWIWRGIDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWATQAMVWQQKACAEEDPQLSGRHWLHAATLYNIAAYPHLKGDDLAEQAQALSNRAYEEAAQRLPGTMRQMEFTVPGGAPITGFLHMPKGDGPFPTVLMCGGLDAMQTDYYSLYERYFAPRGIAMLTIDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLESPRLKVVACLGPVVHTLLSDFKCQQQVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGYWKNDPFSPEEDSRLITSSSADGKLLEIPFNPVYRNFDKGLQEITDWIEKRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: GPPA_ECOLI
Sequence: MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQESQWQSYVHWPLEVH
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities (PubMed:6130093, PubMed:8394006).  In vitro, can hydrolyze pppGp (PubMed:6130093).  Also has exopolyphosphatase activity, catalyzing the release of orthophosphate by processive hydrolysis of the phosphoanyhydride bonds of polyphosphate chains (1000 residues) (PubMed:8394006).
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: TRM5_LEIMA
Sequence: MSAKQDGSTAESRKAPHSYRERVNSTVELAALVYRPLTASGALLSILRGKLYRRRSVRNVLDVVAVRSISGGQGHSAESKVRVEYLTPAEGNANGNSISNISAAPCADIRGSSDTAATSSSPSTPAQPTLLEGRCKMCLLDPTVLKATELCPDPASAAQHCTPVFLLGAAVVGSHVTRQLEAAVQAGQLSRKAADLLQQLHERLAGGPSSVSLTEDTDGSEQPQGLPRAAAAPPPPSNKRRASYTGAVEVTFTPRAVELNYQAYTMSELLSMVLPLREHADLVALSGFEQVGHIAHVNLSAAHLPYADIIGQVILDCNETVSVVVNKVDAISSVFREFKMDIIGLRRRTDSVDGNVVAGADLDDAGEAGGSLTAAERQAIALEALSPTYSLAEARVHRLLTATVRQHGCSFRVPYNRVYWNSRLSFEHTRLVDRMRPGDVLFDVMAGVGPFAVPAAKKGVQVFANDLNPVAAQYMKVNAELNHLPANALHVFNMDGRDFLNSVLFTSVTRAADASLPGHLCTGRRHVTMNLPAIAVEFLDVFQPLSSTCAPASEQRCNASAAAVVNERWNHLPAHVDPNAIDRRTLFHVYCFSAAEDLITDAVRQVEVNLGYTLPPENIEETLMVRDVAPTKRMMCVSFTLPPAFWKNLLASRPGQGGEPGGAHAETASTLVEVEQAAKKARPDKM
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Protein: RL18_RHIE6
Sequence: MASRKEALARRANRVRRHIKSVANGRPRLSVHRSSKNIYAQIIDDVAGKTLASASTLEKDLRGSLKTGADTAAAAAVGKLVAERASKAGVSEVVFDRGAFIYHGRIKALAEAAREGGLTF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PDXK_ECOBW
Sequence: MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRALQERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIFELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVVTSASGNEENQEMQVVVVTADSVNVISHSRVKTDLKGTGDLFCAQLISGLLKGKALTDAVHRAGLRVLEVMRYTQQHESDELILPPLAEA
What is the function of this protein?
B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i. e.  PNP, PLP and PMP.
What are the official names of this protein?
Pyridoxine/pyridoxal/pyridoxamine kinase, PN/PL/PM kinase, B6-vitamer kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxK subfamily.
Protein: PROB_ACIAC
Sequence: MVSSILRDARRIVIKVGSSLVTNEGRGLDETAITEWSRQMAALVNGSGGPRREVIMVSSGAIAEGMKRLGWSARPSEIHELQAAAAVGQMGLAQMYETKLREQGLGSAQVLLTHADLADRERYLNARSTLLTLLRLGVVPVINENDTVVTDEIKFGDNDTLGALVANLVEADALVILTDQKGLYTADPRRDPHAQFVHEAAAGDPSLEAMAGGVGTSIGRGGMITKIIAARRAAGSGASTVIAWGREPDVLLRLTQGEAIGTLLVAQTAKKQARKQWMADHLQLRGAVTVDVGAAAKLRQEGKSLLPIGMVAVEGEFSRGDVIAVRDAAGAEIARGLANYASAEARLLCRRPSSEFERLLGYSAEPEMVHRDNLVLSGG
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_ECOHS
Sequence: MSTLEQKLTEMITAPVEALGFELVGIEFIRGRTSTLRIYIDSEDGINVDDCADVSHQVSAVLDVEDPITVAYNLEVSSPGLDRPLFTAEHYARFVGEEVTLVLRMAVQNRRKWQGVIKAVDGEMITVTVEGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOHH_HUMAN
Sequence: MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGAPS
What is the function of this protein?
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A.  This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16533814, PubMed:16371467, PubMed:19706422).  Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity).
What are the official names of this protein?
Deoxyhypusine hydroxylase, hDOHH, Deoxyhypusine dioxygenase, Deoxyhypusine monooxygenase, HEAT-like repeat-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine hydroxylase family.
Protein: DNLJ_DESDA
Sequence: MVQKNEHQGGQSQHSLFAAGPTGEERRRVQWLTAELERHNHLYHTLDRPEISDDQFDALFRELQDLETRWPELRSLHSPTLRVGGGLLEGLAKKAHSLQMYGLDNVFSAGQWQEFAERMARAWGGDVNGPLPESFWCDPKLDGLALEIIYADGVLQEALTRGDGEVGEVVTDAVRTIRTVPLRLAGPGPFPARLEVRGEVVMYKNDFAVLNEKQEALGLKTFANPRNAAAGTLRQLDTAIIGSRPLRFLAYSLGQALWTPAPVCLLQSEVMSRLREYGFLTPPDGRLCSSVAEVEEYAQWVREHRAAFPMEIDGAVAKLDNLEAQQALGFTARAPRFAVAFKFPAELAQTLLKDIEIQVGRTGVLTPVAMLEPVSVGGVMVSRATLHNEDEIRNRDVRVGDTVMVRRAGDVIPEVVGPVLEKRPENAREYVFPHTCPACGQPAYREEGEAAWRCENMACSAIRLRAITHFVSKAGLDIAGVGQKWIEQLVTSGRVQSPADLFTLTVQELLGFERMGEVLAHKFVDALARAVHSATLPRLISALGIRHVGEQTARTLALHFETLDELENAGAETLLSLPDVGPEVASSIHNFFNSPANREQLERFRALGLWPRGGRSGGGSSGSTGEGGLASGPLAGKNILFTGTLSMPRSEAEKLAETAGATPLGGVSKKLDYLVAGEKAGSKLEKAQALGVTVLTEEEFMTMLREAKAASE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: LPXK_AGRRK
Sequence: MVSEAPPFWWRKPDWRAWGLSPFSFLYGRVAGHRMVHGRRASVPVPVICVGNFTVGGAGKTPTALALARAAKTKGLKPGFLSRGYGGSLDVTTVVDPHDHHATAVGDEPLLLAREALTVIARRRADGAERLVREGADLIIMDDGFQSAQLAIDYALVVIDATRGIGNGHLVPGGPVRAPLRTQLGYTSGLLKVGDGNAADRIVRLAARAGKPFFSASIKTLGQEDLQGRKVLAFAGIADPTKFFRTVETLGAGIAVRRSFGDHEHLEEDEIADILDVADRDGLEIVTTSKDYVRLIGHHGRADELLARCRVIEIAMVFDDPHAPELIIDRAIAAARERRLREGWTGKTLLPSGEK
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: Y3777_ANAD2
Sequence: MDIQYLMRQAKKLEKAMADAKEKLAEIAVEAESGGGLVKVAMNGKCEITRLTVDPKAVDPNDKALLEDLVTAAVNAAVEKARTAADESMSKATGGIKIPGIAG
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein A2cp1_3777.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SUNS_BACSU
Sequence: MKLSDIYLELKKGYADSLLYSDLSLLVNIMEYEKDIDVMSIQSLVAGYEKSDTPTITCGIIVYNESKRIKKCLNSVKDDFNEIIVLDSYSTDDTVDIIKCDFPDVEIKYEKWKNDFSYARNKIIEYATSEWIYFIDADNLYSKENKGKIAKVARVLEFFSIDCVVSPYIEEYTGHLYSDTRRMFRLNGKVKFHGKVHEEPMNYNHSLPFNFIVNLKVYHNGYNPSENNIKSKTRRNINLTEEMLRLEPENPKWLFFFGRELHLLDKDEEAIDYLKKSINNYKKFNDQRHFIDALVLLCTLLLQRNNYVDLTLYLDILETEYPRCVDVDYFRSAILLVDMQNKLTSLSNMIDEALTDERYSAINTTKDHFKRILISLNIQLENWERVKEISGEIKNDNMKKEIKQYLANSLHNIEHVLKGIEV
What is the function of this protein?
Transfers a hexose moiety onto 'Cys-41' of bacteriocin sublancin-168 (SunA).  Accepts UDP-glucose (UDP-Glc), UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-galactose (UDP-Gal), UDP-xylose (UDP-Xyl) and GDP-mannose as substrate.
What are the official names of this protein?
SPbeta prophage-derived glycosyltransferase SunS.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: RS20_BUCAI
Sequence: MANIKASKKDALTSEKRRKKNSSRRSMIRTFVKKVRVAIMSGNKTTAEDAFKKMQPIIDSHVNKGLIHKNKAARYKSNLSLQIKKISKI
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: Y317_STAAW
Sequence: MASLKNKHFMIGLTLTFIVALFSFLAAKLPILDKVGALTIAILIAILYRHFRGYPEQYSSGITFSSKYLLRFAIILYGLKLNIFDIIGQGSRLLAIDVGVVIFSIVMMLFVNKLLHGDKNIALLLGVGTGVCGAAAIAAVAPIFKSREKDTAISIGIIALIGTIFSLIYTAIYAIFSMTTNVYGAWSGVSLHEIAHVVLAGGFGGSDALKIALLGKLGRVFLLIPLTIVLILIMRFRSSESSSNGRISIPYFLIGFVIMALVNTYVTIPSALLNILNTVSTICLLMAMVALGLNVAFKDLKNRALKPLMTIIITSICLSSLAFIVVHWLYS
What are the official names of this protein?
UPF0324 membrane protein MW0317.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLMF_ECOBW
Sequence: MSAQKPGLHPRNRHHSRYDLATLCQVNPELRQFLTLTPAGEQSVDFANPLAVKALNKALLAHFYAVANWDIPDGFLCPPVPGRADYIHHLADLLAEASGTIPANASILDIGVGANCIYPLIGVHEYGWRFTGSETSSQALSSAQAIISSNPGLNRAIRLRRQKESGAIFNGIIHKNEQYDATLCNPPFHDSAAAARAGSERKRRNLGLNKDDALNFGGQQQELWCEGGEVTFIKKMIEESKGFAKQVMWFTSLVSRGENLPPLYRALTDVGAVKVVKKEMAQGQKQSRFIAWTFMNDEQRRRFVNRQR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y125_METJA
Sequence: MPKRDIKAFLYDILSYMDDIINFTKDMDYEEFINNKAIKYAVIRCLEVIGEAVKKIPKDIREKYPHIPFKELAGMRDKLIHQYFGVDYLTVWETAKYEIPEIKKEFEKIIKDLEEK
What is the function of this protein?
Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase.  Probably neutralized by cognate antitoxin MJ0126.  Neutralization may be due to AMPylation by MJ0126.
What are the official names of this protein?
Putative RNase MJ0125, Putative toxin MJ0125.
What is the protein family that this protein belongs to?
Belongs to the HepT RNase toxin family.
Protein: APT_NEIMB
Sequence: MLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDLLVYRYMDQKIDIVAGLDARGFIIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEAAVEIHTDAVKLGSRVLLVDDLIATGGTMLAGLELIRKLGGEIVEAAAILEFTDLQGGKNIRASGAPLFTLLQNEGCMKG
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_STAAS
Sequence: MRKLVVGSRRSKLALTQSQQFIDKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLFVKEIQHELFEKNIDMAIHSLKDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTEDYDAIILAAAGLRRMGWSDDIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGSCQVPIAGYATISDQKEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEIIKRLNEQH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: FIMB_BORPE
Sequence: MARWRRRLGVAALGAAMLASLAPAARASLVITGTRVIYNAGSPETTVKMSNEGQAPALMQAWIDDGNAEAKPDEVQVPFFLTPPLARVDPGKGQTLRIFFNGYPDGKTLPSDRESVFWLNVLEVPPKATPEEGHGVLQLTIRSRLKLFYRPKGLSGNPLTAAADLTFKRKPNGVLEVHNPTPYYVNLQKLEVGENGAHGSKTPWMLAPLSSDELRLKGTGAKSVQYWAIDDFGGVTPYQAAIAD
What is the function of this protein?
Required for the biogenesis of the filamentous hemagglutinin and the fimbria.
What are the official names of this protein?
Chaperone protein FimB/FhaD.
What is the protein family that this protein belongs to?
Belongs to the periplasmic pilus chaperone family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MATK_ILLOL
Sequence: MEELQGYLGIDRSCQQRFLYPLLFQESIYALAHDYGLNGSILYEPIENLGYDNKPSLLIVKRLIIRMHQQNLFFILVNGSNQNRFVGHNRSFYSQMISEGFAGIVEIPLSMRLASSLEQIAKSHNLRSIHSIFPFLEDKFSHLNHVSDILIPHPVHLEILVQTLRRWIQDAPSLHLLRFFLHGHPNWNSLITPKKSISLFSKENPRFFLFLYNSYVYEYESILVFLHKQSSHLRSISSGAFLERTNFYGKTEHLLVVLRNDFQKTLWLWLFKDPFMHYARYQGKAIMASKGTHLLMKKWKYHLVNFWQLHFYLWSQSGRIRINELSNHFFYFPGYLSGIRLNPSVVRGQMIENSFMIDTGIKKFDMIVPIIPLIGSLVKAKFCNISGYPISKSVRADSSNSDIINRFGRICRNLSHYHSGSSKKHNLYRIKYILRLSCAKTLARKHKSTVRTILKRLGSELLEEFLTEKEEILSLISPRTSSPPHREEGIWYLDIIHIHGMSNHS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: VTU4_DROPS
Sequence: MKTVAFLAVVVLFAAFACASCSSSYAAPAPAPAAAPASSYSSVPAPPCPKNYLFSCQPNLVPAPCAQQAAPAAYGSAGAYTEQVPSYIGFAPYQQLQQYHQRIGNAALIDELRSLGQGIQGQQY
What is the function of this protein?
Major early eggshell protein.
What are the official names of this protein?
Vitelline membrane protein Vm32E.
What is the protein family that this protein belongs to?
Belongs to the vitelline membrane family.
What are the subcellular locations of this protein?
Secreted.
Protein: ABDH_ECO45
Sequence: MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVNAAVRAADAAFAEWGQTTPKARAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINVLFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTAPSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGSPDDESTELGPLSSLAHLERVSKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTLFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal.  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: ILVC_CAMJE
Sequence: MAITVYYDKDCDLNLIKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVKAKNAGFEVVSVSEASKIADVIMILAPDEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVVPKGVDVIMIAPKAPGHTVRNEFTLGGGTPCLIAIHQDESKNAKNLALSYASAIGGGRTGIIETTFKAETETDLFGEQAVLCGGLSALIQAGFETLVEAGYEPEMAYFECLHEMKLIVDLIYQGGIADMRYSISNTAEYGDYITGPKIITEETKKAMKGVLKDIQNGVFAKDFILERRAGFARMHAERKNMNDSLIEKTGRNLRAMMPWISAKKLVDKDKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: IF2_RUEST
Sequence: MSDSDGKKTLGLRGSGSRPGNVKQSFSHGRTKNVVVETKRKRVVVPKPGAGKGGAGGVAAGDASRRPAGISDAEMDRRLKALQAAKAREAEEAAQREAEEKARAEERERRRAEQEAKEREQREAEEKARQKAEEEERKRQEEAEAAKKRAAADKAAAAAPKSDAGVAPARPAPGGAPKPAAGPRKAEREREERGRGAKGRNDGGRRSGKLTLSQATGGEGGRQRSVASMKRKQERARQKAMGQVEREKIIRDVQLPEAIVVSELANRMAERVADVVKALMNMGMMVTQNQTIDADTAELIIEEFGHNVVRVSDADVEDVIKEIEDKEEDLQPRPPVITIMGHVDHGKTSLLDAIRDAKVVAGEAGGITQHIGAYQVTTDSGAVLSFLDTPGHAAFTSMRSRGAQVTDIVVLVVAADDSVMPQTVEAINHAKAAGVPMIVAINKIDKPAADPNKVRAELLQHEVIVEAMSGEVQDVEVSAHTGQGLDELLEAIALQAEILELKANPNRAAQGAVIEAQLDVGRGPVATVLVQTGTLRQGDIFVVGEQYGKVRALINDKGERVKEAGPSVPVEVLGLNGTPEAGDVLNVTETEAQAREIAEYREQAAKDKRAAAGAATTLEQLMQKAKEDENVSELPILVKADVQGSAEAIVQAMEKIGNDEVRVRVLHSGVGAITETDIGLAEASGAPVMGFNVRANASARNTANQKGVEIRYYSVIYDLVDDVKAAASGLLSAEIKENFIGYAEIKDVFKVSNVGKVAGCLVTEGVARRSAGVRLLRDNVVIHEGTLKTLKRFKDEVAEVQSGQECGMAFENYDDIRPKDVIEIFEREEVTRTLD
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APA_MYCBP
Sequence: MHQVDPNLTRRKGRLAALAIAAMASASLVTVAVPATANADPEPAPPVPTTAASPPSTAAAPPAPATPVAPPPPAAANTPNAQPGDPNAAPPPADPNAPPPPVIAPNAPQPVRIDNPVGGFSFALPAGWVESDAAHLDYGSALLSKTTGDPPFPGQPPPVANDTRIVLGRLDQKLYASAEATDSKAAARLGSDMGEFYMPYPGTRINQETVSLDANGVSGSASYYEVKFSDPSKPNGQIWTGVIGSPAANAPDAGPPQRWFVVWLGTANNPVDKGAAKALAESIRPLVAPPPAPAPAPAEPAPAPAPAGEVAPTPTTPTPQRTLPA
What is the function of this protein?
Might function as an adhesin for host (human) cells.  Cell surface Apa binds to human PSP-A (SFTPA1) via its glycosylated sites where it might down-regulate the immune response; PSP-A probably binds other bacterial proteins as well (PubMed:17158455).
What are the official names of this protein?
Alanine and proline-rich secreted protein Apa, 45/47 kDa antigen, FAP-B, Fibronectin attachment protein.
What is the protein family that this protein belongs to?
Belongs to the Apa family.
What are the subcellular locations of this protein?
Secreted. Cell surface.
Protein: COMD9_HUMAN
Sequence: MAALTAEHFAALQSLLKASSKDVVRQLCQESFSSSALGLKKLLDVTCSSLSVTQEEAEELLQALHRLTRLVAFRDLSSAEAILALFPENFHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAVTVELSKETLDTMLDGLGRIRDQLSAVASK
What is the function of this protein?
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237).  May down-regulate activation of NF-kappa-B (PubMed:15799966).  Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).
What are the official names of this protein?
COMM domain-containing protein 9.
What are the subcellular locations of this protein?
Nucleus. Cytoplasmic vesicle.
Protein: TSSK6_HUMAN
Sequence: MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQFSPSARPSAGQVARNCWLRAGDSG
What is the function of this protein?
Required for sperm production and function.  Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).
What are the official names of this protein?
Testis-specific serine/threonine-protein kinase 6, TSK-6, TSSK-6, Testis-specific kinase 6, Cancer/testis antigen 72, CT72, Serine/threonine-protein kinase SSTK, Small serine/threonine kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Protein: CH10_CAUVC
Sequence: MKFRPLGDRVLVKRVEEETKTKGGIIIPDTAKEKPQEGEVVAVGPGARNDKGDVVALDVKAGDRILFGKWSGTEVKVDGQDLLIMKESDVLGVVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.