Protein: AGRV1_MOUSE
Sequence: MSVTSEPGMISSFLLVYLSTLFISFVFGEAEIRFTGQTEFFVNETSTTVIRLVIERIGEPANVTAIVSLSGEDTGDFFDTYAAAFIPARGTNRTVYIAVCDDDLPEPDETFTFHLTLQKPSANVKLGWPRAASVTILSNDNAFGIISFSTPSSISVIEPRSRNASVPLTLIREKGTYGMVTVTFDVSGGPNPPEEDLNPVRGNITFPPGRATVIYNVTVLDDEVPENDELFLIQLRSVEGGAEINASRSSVEIIVKKNDSPVNFMQSVYVVPEDDHVLTIPVLRGKDSDGNLIGSDETQVSIRYKVMTWDSTAHAQQNVDFIDLQPDTTLVFPPFVHESHLKFQIIDDLIPEIAESFHIMLLKNTLQGDAVLMGPSTVQVTIKPNDKPYGVLSFNSILFERPVIIDEDTASSSRFEEIAVVRNGGTHGNVSVSWVLTRNSSDPSPVTADITPASGTLQFAQGQMLAPISLVVFDDDLPEEAEAYLLTILPHTIQGGAEVSEPAQLLFYIQDSDNVYGEIAFFPGESQKIESSPSERSLSLSLARRGGSKGDVRVIYSALYIPAGAMDPLRAKDGILNTSRRSSLLFPEQNQQVSIKLPIRNDAFLQNGAHFLVQLEAVVLVNIFPPIPPVSPRFGEIRNISLLVTPAIANGEIGFLSNLPIILHEPKDSSAEVVSIPLHRDGTDGQATVYWSLRPSGFNSKAVTLDDAGPFNGSVVFLSGQNETSINITVKGDDIPELNETVTLSLDRVSVDSDVLKSGYTSRDLIILENDDPGGIFEFSYDSRGPYVIKEGDAVELRITRSRGSLVKQFLRFHVEPRESNEFYGNMGVLEFTPGEREVVITLLTRLDGTPELDEHFWVILSSHGERESKLGRATLVNITILKNDYPHGIIEFVSDGLSASIKESKGEDIYHAVYGVIRTRGNFGAVNVSWMVSPDFTQDVFPVQGTVCFGDQEFFKNITVYSLVDEIPEEMEEFTIILLNATGGAQTGIRTTASLRILRNDDPVYFAEPCVLRVQEGETANFTVLRNGSVDGACTVQYATVDGKASGEEGDFAPVEKGETLVFEVGSREQSISVHVKDDGIPETDEPFYIVLFNSTGDTVVYEYGVATVIIEANDDPNGVFSLEPIDKAVEEGKTNAFWILRHRGHFGNVSVAWQLFQNASLQPGQEFYETSGTVNFTDGEETKPVILRAFPDRIPEFNEFYILRLVNISGPGGQLAETNFQVTVMIPFNDDPFGIFILDPECLEREVAEDVLSEDDMSYITSFTILRQQGVFGDVRVGWEVLSREFTAGLPPMIDFILLGSFPSTVPLQPHMRRHHSGTDVLYFSGLEGAFGTVDPKYQPFRNNTIANFTFSAWVMPNANTNGFLIAKDDSHGSIYYGVKIQTNETHVTLSLHYKTFGSNVTYIAKSTVMKYLEEGVWLHVLIILDDGIIEFYLDGKAMPRGIKSLKGEAITDGPGILRIGAGMDGGARFTGWMQDVRTYERKLTPEEIYELHAVPARTDLHPISGYLEFRQGESNKSFIVAARDDSEEEGEELFLLKLVSVDGGAQISKENTTARLRIQKSDNANGLFGFTGACIPEMTEEGSTVSCVVERTRGALGYVHVFYTISQIESEGINYLVDDFANASGTITFLPWQRSEVLNLYVLDEDMPELNEYFRVTLVSAVPGDGKLGSTPISGASIDPEKETTGITVKASDHPYGLMQFSTGLPPQPEDSMSLPASSVPHITVQEEDGEIRLLVIRAQGLLGRVTVGFRTVSLTAFSPEDYQSTAGTLEFQSGERYKYIFVNITDNSIPELEKSFKVELLNLDGGVSDLFRVDGSGSGEADTDFFLPPVLPHASLGVASQILVTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVVLNVTRTRGALSAVTLQWKVDSDLDGDLAITSGNITFETGQRIASITVEILSDEEPELDKALTVSILNVSSGSLGVLTNATLTILASDDPYGVFIFPNKTRPLSVEEATQNVALSIIRLKGLMGEVAVSYATIDDMEKPPYFPPNLARATQGGDYISASGLALFRVNQTEATITISILDDAEPERSESVFIELFNSSLVDKVQNRPIPHSPRLGPKVETVAHLVIVANDDAFGTVQLSATSVHVAENHVGPIINVTRTGGTFADVSVKFKAVPITAAAGEDYSIASSDVVLLEGETTKAVPIYIINDIYPELEETFLVQLLNETTGGATLGPLREAVITIEASDDPYGLFGFQNTKFIVEEPEFNSVRVNVPIIRNSGTLGNVTVQWVAIINGQFATGDLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVVQVQLAAASGGGTIGLDRVANIVIPANDNPYGSVAFVQSVFRVQEPLERSSYANITVRRSGGHFGRLLLCYGTSDIDVVARAVEEGEDVLSYYESPTQGVPDPLWRTWVNVSAVEETQYTCATLCLKERACSAFSVVSGAEGPRCFWMTSWVSGTVNSSDFQTYKKNMTRVASLFSGQAVAGSDYEPVTRQWAVILEGDEFANLTVSVLPDDAPEMDESFLISLLEVHLMNISDSFKNQPTIGHPNTSAVVIGLNGDAFGVFIIYSVSPNTSEDGLCVEVQEQPQTSVELVIYRTGGSLGQVMVEWRVVGGTATEGLDFMGAGDILTFAEGETKKMAILTILDDSEPEDNESILVRLGATEGGSRILPSSDTVTVNILANDNVAGIVSFQTASRSVIGHEGEMLQFHVVRTPPGRGNVTVNWKVVGQNLEVNFANFTGQLFFSEGTLNKTIFVHLLDDNIPEEKEVYQVVLYDVKTQGVSPAGVALLDAQGYAAVLTVEASDEPHGVLNFALSSRFVVLQEANVTIQLFVNREFGSLGAINVTYATVPGIVSLKNNTEGNLAEPESDFIPVVGSLVLEEGETTAAISITVLEDDIPELKEYFLVNLTHVDLIMAPLTSSPPRLDSEGLTAQIVIDANDGAQGMIEWQRNRFEVNETDGVVTLVAQRSRAALGQVSLFMYAQNLEAQAGLDYMRTPQILHFTDGERFKHVDVMILDDDMPEGDERFQLLLTNPSPGLELGKNTIALITVLANDDGPGVLSFNNSGHIFLREPTSLYVQESVAVLVIVREPAQGLFGTVAVQFVVTEVNSSTESKDLSPSKGFIVLEEGVRSKTLRISAILDTEPEMDEHFVCTLFNPTGGARLGAHVQTLITIFQNQAPLGLFSISAVENSATSIDVEESNRSVYLNVSRTNGLDLTASVQWETVSETAFGMRGMDVVFSIFQSFFDKTALDWCFFTVEGSVYGVMLRKSSLVVYRWQGTFVPVEDLKVESPKTCEAFNIGVSPYLVITHGERSGEKPSINSVYMLTAGFRLVLIQTIIISGSCQVRHFTSDSQDYFIIASRRNDSELTQVFRWNGNNFAWHQTLPVRGVLGMALFSRGGSVFLAISQANIRQTSLLFTWSGTQFINFQELPISGITQVEALSSGDDVYLCFAKNTFLGNQNAIDIFVWEMGHSSLRYFQSLDFAAVKRIRSFTPASGIVHILLTAQDGSALYCWNSELNAFSFVLEAPAAHDAAFVTVKSLNSSKTLIALVGATDSHLYELTYVSSQSDFIPSLGELIFEPGDKEAIIAVNVLDDTVPEKEESFRVQLKSPRGGAEIGINSSVRVTVLANDGAYGVVAFAQNSLHKQLEELERDSLVTLNVERLRGTHGRITVAWEAAGSVSDVFPTSGVISFTEDQAMSMITLTVLADDLPELSEAVVVTLTQIVTEGVEDPLKGATIDQSRSRSVLTILPSDSPYGAVRWHTESLFNRVPEPTENITVVQLHIVRDKGLFGDISIHLIAKPNFLLHINNQATEDEDFVLQDSVIIMKENIKETHAEVAILPDEVPELDEGLIVTIAAVNLVNPNFPAEQPRVQRPRMESAEILIEENDDPRGIFNFHVVRDVGGVIIAHEGPPPLNVLQVPVVRMAGTFETVNVYWKATPDSAGLEDFQPSHGMLQFADGQVIAPILVTIIDDSEFELLETFTISLVSVTGGGRLGDDVSVNVVIAPNDSPFGIFGFEKKTVMVDGPLLSDDPDSYVTLTVVRSPGGKGAVRLHWAIEEKAKDDLSPLNGTLYFDETESQKSVILHTLKDGMVGEDRRFIIELTAADEVEISPVKGSASVIIRGDKSISEVGIASSSRHIIIGEPSATYNGTAIIDLVRGPGVSGEITVNWKILPPSRGEFVETSGQLTMLDGQTAATVVIQVLNDDIPEEKCHYEFQLTEISEGRMLHEASVSARITMVASDAPYGRFSFSHEQLHVSKAAQRVNVTVVRSGGSFGRARVLYETGSRTAEAGWDFVPASGELLFEAREKMKSLYIDILDDDLPEGPEEFVLAITRVDLQGRGYDFTIQENGLQIDQPPEIGNISIVRIIIMKNDNAEGIIEFDPKYTDISVEEDAGVITLPVLRLHGTYGHVSADFSSRGFSAVPGGYVLRGSSVTFQHGQNLSFINVSIIDDNGSEFEKQFEILLIGATGGAILGRHLVSKITIAKSDSPFGIIRFLNQSKISLPNPSSTMALHLVLERTGGLLGEIQVSWEVVGPDAEEPLPPHNGDFADPVSGTVSFGDGEGGVRSIILRVCPHEETEAEETFIVQLKPLREAKLDPRAKAVTLTIQKFGDPNGVIHFAPESLSKRRFSEPPPSDGPLLVSFLVTRSKGTSGDIKVHWELSSEFDITRDFLSTRGFFTIADGESDANFDVHLLPDDVPEIEEEYAVQLVSVEGGAELDLGKCTARFSVSANDDPHGVFALYSDRQSVLIGQNLDRSIQINITRLAGAFGAVAVRVQILSDNKEDPVATENEERQLVITDGARYKVGLVPLKNQVFLSLGSNFTLQLVSVRLLSGPFYGIPTILQEAKNAILSVPEEAANSQVGFESAAFQLMDIKAGTSQVMVSRKGTYGRLSVAWTTGYAPGSEIPEPIVIGNMTPTLGSLSFVHGEERKGVLLWTFPSPGRPEAFVLHLSGLRSSAAGGAQLRSGFTTAEIEPMGVFQFSPSSRNITVSEDAQTIRICVQRLFGFHGDLIKVSYETTAGSAKPPEDFEAVQKGEVFFQRFQPEIDFEITIINDQLPEIEETYYINLTSVETRGLGKGGVNWRPRLNPDLSVAVVTIVDNDDLTGAAVSVPVTAGTVAVDSTLLAMETGSTTHPNKSKITTIPYTTEVFAPVTETVTVSAIPEKLATAHSVISVKPDVVPGTVVASVYGTLSIGPPIVYVSEEMKNGTLSTADILIQRMGGFAGNVTITVKTFGGRCAQKEPSVWPFQDVYGVGNLTTWAVEEEDFEEQLLTLTFLYGERERKIAVQILDDDDAEGQEFFYVFLTDPQGGAEIVRGKDSTGFSAFAVIIISGSDLHNGIIGFSEESQRGLELREGADKNSQRLVVTRQPNRAFEEVQIFWRVTLNQTVTILQEKGANLTDELRFVAGVTTCTGGQTRCFIHLELNPKKVHQVEMPFFVELYDVTAGAAINNSARFAPIKLSKSGAPQSLVSFSVGSRLAVAHKKSTLISLQVARDSGTGIMMSVNFITQELRSAETVGRVLISPAVSGKDFVRTEGTLVFEPGQKSAVLDVVLTPEAGSLNKFPKRFQIVLFDPKGGARIDKVYGTANITLISDADSQAVWGLEDLLHRPLHEDILNRVLHNLNLRVATESTDEQLSAVMLIMEKITMEGRNQAFSIKSRTLLYELLCVLINPKRKDTRGFSHFVEVAEHFAFSLLTDVTCGSPGEKSKTILDSCPYLSILALHWNPQQINGHKFEGKEGDYIQIPERLLDVPEAEMLDGKNACTLVQFVEYSSQQWFIAGDNLPALKDKVLSLNVKGQSAQPLPNNNEVLYRIHAAEPRVVPHTSRCLLWNQAAASWLSDSQFCKVVEDASDYVECACSHMSVYAVYAQTDNSSSYNEAFFSAGLICISGLCLAVVSHMFCARHSMFAAKLLTHMMVASLGTQILFLASAYASPHLSEESCSAVAAVAHYLYLCQFSWMLIQSVNFWYVLVVSDEHTERRCLLFCLLSWGLPSFVVILLILILRGIYHRSMPQIYGLIHGDLCFIPNIYAALFTAALVPLMCLVVVFVVFIHAYQLKPQWKGYDDVFRGRTNAAEIPLILYLFALISMTWLWGGLHMAYGHFWMLVLFVIFNSLQGLYVFVVYFILHNQTCCPMKASYTVEMNGHPGPSTAFFTPGSGIPPAGEINKSTQNLINAMEEVPSDWERSSFQQTSQASPDLKTSPQNGASFPSSGGYGPGSLIADEESQEFDDLIFALKTGAGLSVSDNESGQGSQEGGTLTDSQIVELRRIPIADTHL
What is the function of this protein?
Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1.
What are the official names of this protein?
Adhesion G-protein coupled receptor V1, ADGRV1, G-protein coupled receptor 98, Monogenic audiogenic seizure susceptibility protein 1, MASS1, Neurepin, Protein rueda, Very large G-protein coupled receptor 1, VLGR1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, stereocilium membrane. Photoreceptor inner segment. Note=Localizes at the ankle region of the stereocilia (PubMed:16775142, PubMed:27525485). In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex (PubMed:20502675, PubMed:24334608). SUBCELLULAR LOCATION: [Isoform 4]: Secreted. SUBCELLULAR LOCATION: [Isoform 5]: Secreted.