Protein: ELT2_CAEEL
Sequence: MDNNYNDNVNGWAEMEPSQPMGGLRLPTQNMDPPEQNNESQLSELPRMKIDNDYASPIERQSVITSGTNNYEPKVETVTSFFHTGIDYSNFGMLDQTTMQPFYPLYSGIPVNTLGTFSGYTNSIYDKPSLYDPSIPTINIPSTYPTVAPTYECVKCSQSCGAGMKAVNGGMMCVNCSTPKTTYSPPVAYSTSLGQPPILEIPSEQPTAKIAKQSSKKSSSSNRGSNGSASRRQGLVCSNCNGTNTTLWRRNAEGDPVCNACGLYFKLHHIPRPTSMKKEGALQTRKRKSKSGDSSTPSTSRARERKFERASSSTEKAQRSSNRRAGSAKADRELSTAAVAAATATYVSHADLYPVSSAAVTLPDQTYSNYYQWNTAATAGLMMVPNDQNYVYAATNYQTGLRPADNIQVHVMPVQDDETKAAARDLEAVDGDS
What is the function of this protein?
Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' (PubMed:7782329, PubMed:15733671, PubMed:18003741, PubMed:18024960, PubMed:18448117, PubMed:26700680, PubMed:26016853, PubMed:26963674).  Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1, vit-2 and lev-11, and itself (PubMed:9659934, PubMed:10518545, PubMed:15733671, PubMed:18448117, PubMed:19111532, PubMed:26700680, PubMed:26963674).  Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine (PubMed:20807527).  Regulates intestinal gene expression in response to hypoxia to promote longevity (PubMed:25284791).  Modulation of longevity may, in part, be the result of regulation of expression of daf-16 isoforms d and f in the intestine (PubMed:24834345).  Regulates tissue specific gene expression at basal levels and in response to bacterial infection in the intestine to control innate immunity (PubMed:16968778, PubMed:21168435, PubMed:25340560, PubMed:26016853).  Plays a role in the induction of metal-responsive genes, activating gene expression from zinc-activated promoters and iron-dependent promoters and enhancers (PubMed:18024960, PubMed:22194696, PubMed:25552416).  May regulate the expression of genes that control sensitivity to oxidative stress, in a mab-3-dependent manner, and osmotic stress, in conjunction with the GATA region-binding transcription factor elt-3 (PubMed:17901115, PubMed:20498281, PubMed:20126308).  May play a role in sphingolipid signaling by regulating the expression of the sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735).  May act with the Notch signaling pathway to promote endodermal gene expression (PubMed:18003741).  Has a protective role in response to infection by Gram-negative bacteria such as S. enterica, E. coli, P. aeruginosa and B. pseudomallei, Gram-positive bacterium E. faecalis and fungal pathogen C. neoformans (PubMed:16968778, PubMed:17183709, PubMed:21168435, PubMed:23980181, PubMed:30265660).  An association with the 26S proteasome regulatory subunit rpt-6, in part, controls gene expression in response to infection by P. aeruginosa (PubMed:30265660).  Regulates gene expression during the recovery phase following a bacterial infection (PubMed:25340560, PubMed:30265660).  May act with p38-activated transcription factors to control p38 gene induction in response to bacterial infection (PubMed:22967128, PubMed:26016853).  Controls lysosome formation in the intestine by controlling lysosomal gene expression (PubMed:26828939).
What are the official names of this protein?
Transcription factor elt-2, GATA-type domain-containing protein elt-2.
What are the subcellular locations of this protein?
Nucleus. Note=Expressed in discrete foci within nuclei of the gut in embryos.