PharMolix/UniProtQA huggingface dataset:
Protein: ACRD_ASPA1
Sequence: MAEIHDITGLLKPYLSGTNLVWTLLLVGYIIPKLFQYLQRLFSPVSRIPGSWLHKLTSLPLKIAIAKGESHIFTVDLHKKYGPIVTLSPTMISISDAREIKRIVHTEDWAKSEAVYGNFRQDPQRPTLLAFTDKKAYSQRKRLVSSMFGLRYIRSMQPLMRNCISVLMDELDKQCANGATAVDMQHMIQSLAADIIGVTTFGQTFDLVKNGSHPLPDRLKQALKLSGILQFMPWLTKIPFIPNRDPYVSWFTNEIVAKRRAQIASRQGPPREDLLQKMIEAADESPTSPFRVSDIQDESVVLLIAGSETTANAELFTLIHLLRHPSKLATLYEEIDRWYPRNDPRPTDCDYSMSGMVYLQACIDETMRLVPGQATGSPRESRKDETLLGYDIPKGTTVFPTTQEVHLDETLWPNATEFLPERWLDVYAKGEANSLPYYPFSAGSRVCIGKHFAAQEMHLSLVSLLRRFQFEYVSGQDESTVFRIAQQMRGHRYLMTVGRR
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the cluster that mediates the biosynthesis of acurin A, a highly reduced polyketide coupled to a serine via a peptide bond (PubMed:32234543).  The activities of the highly reducing polyketide synthase acrA and the nonribosomal peptide synthetase acrB are collectively responsible for the synthesis of the acurin A core structure with a heptaketide backbone produced by acrA covalently fused to a L-serine by acrB (PubMed:32234543).  After the formation of the PK-NRP hybrid product, it is detached from acrB by reductive release to set up the formation of the lactam ring by aldol condensation (Probable).  The hydrolyase acrC then catalyzes water loss to generate a double bond in the ring (Probable).  This double bond is probably reduced, which is followed by three oxidations at C-22 to generate the carboxylic acid moiety, involving probably the FAD-binding monooxygenase acrE and the cytochrome P450 monooxygenases acrD and acrF (Probable).  Finally, a last methylation step performed by the O-methyltransferase acrG leads to the production of acurin A (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase acrD, Acurin A biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: FSTL3_HUMAN
Sequence: MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAECCASGNIDTAWSNLTHPGNKINLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPDLSVMYRGRCRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSCAGTPEEPPGGESAEEEENFV
What is the function of this protein?
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN.  Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B.  Involved in bone formation; inhibits osteoclast differentiationc.  Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma.  Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
What are the official names of this protein?
Follistatin-related protein 3, Follistatin-like protein 3, Follistatin-related gene protein.
What are the subcellular locations of this protein?
[Isoform 1]: Secreted. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Note=Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.
Protein: YKQ7_CAEEL
Sequence: MSNYNKPIQLLCVLVVVLFFINNQFVQRTTWSRGLRSPPLDSRIFQEKSEIERSTLPPIPKGFLSSKLASTARLANHIFELVSVYGMAKSLNRKPAIFVEDSKYNLLITGVRKVLPGLLDEFQIFEYPVHNKATKVPLSEKCCIFDNPDKFNNISSEYLHLTGHFYQSWKYFDKYKEKVQSFVKPAIDFSPLPNSDSSNFISRICIHIRRTDFVDGQHHSSNVSFIKPALEFIKEREQKDVNKKMLTVIMGDDPDFEAKMFEGTVRAKKEAKIEETTKYFVSENTPQDDLAYSHYSCDATLITAPSSTFGWWLGYLSKGQAVYYQDIRSTNDVNYKKGVLDPDDFFVPSWTSIMLDENKKVVVVT
What are the official names of this protein?
Putative glycosyltransferase C06E1.7.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 11 family.
Protein: RSC58_YEAST
Sequence: MTESVGGNKLVDFLVNVQSILNAASVKCHVVDESFPAKFFEKNPDKIYESYCKFIKNRSNSEGLIRNEDKLVLTTINKRFENGEYEPIQGGFYKLYHDIKLVCTILIHFYPQGTRNYQLVDKFYKFSSELLLRECCRIGIALTQTNNIKSRSGKLLSGNEMDEYDDDDATELDKIISYDFIKISMNYTVPISQTYQIRTKDMDLFSSIISKSNLDKRPHELPNTNFKINNVLPQTDIENEAPRLGFVGANTSNIPDPTLPPTEMMTRFLHPNWYALPTTVWLKYGNYNSWAPSFNENGTVVDSTTRGLIWLERIGYMDLYEKNEKKVKQEELLNTNEEGINRKQNDENNKNVDGKSNGVQDDGGDNDNDATIASANSESTENKEQFIIKLQNLYNWTPSNYIGDDEIENFRNGTPDKLVSDSLLKLKRLRKERILNKVLKPTTEERELYFKVKRILKEVILAKKVSKVPINNVRAFPVLQTNYNGSIPVVRAQPGRKRKHKK
What is the function of this protein?
Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning.  RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA.  The reaction requires ATP and involves an activated RSC-nucleosome intermediate.  Remodeling reaction also involves DNA translocation, DNA twist and conformational change.  As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.
What are the official names of this protein?
Chromatin structure-remodeling complex protein RSC58, Remodel the structure of chromatin complex subunit 58.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Protein: ARGC_PAEAT
Sequence: MTISVAVSGASGYAGGEVLRLLAGHPNVTIGAITAHSNAGSRLGELQPHLHGLASRILEDTTVENLSGHDVVFLALPHGASAEIAAQLPEGTVVIDAGADHRLQDAAAWERFYGSAHAGTWPYGLPELPGQREALKGATRIAVPGCYPTSALLALTPGFANNLLLTDDVVIVSASGTSGAGKAAKVNLIGAEVMGSMSPYGVGGGHRHTPEIEQGLSNAAGEPVTVSFTPTLVPMSRGILTTATAKVGHGVSYAELRQAWADAYDDEPFVHLLPEGQWPTTKSVQGSNHAVMQLAFDAHTGRVIVTCAIDNLTKGTAGGAVQSMNIALGLDETAGLNLQGVAP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTH_BRUME
Sequence: MVPHGSCPSGAREVTFEGWRRERGEASMSDVHRTIRVNRSGSKFRRALSFFGPGYLVAVGYMDPGNWATSLAGGSRFGYALLSVVLLSNLMAVLLQALCTRLAVATGRDLAQACRDAYPRFLAWPLWLLAELAICATDLAEVIGTAIGLNLLFGIPLEIGVILTAVDVLLVLYLQNKGFRRVEALIITLLGVIALCFLTQIIMAQPQWGEVIKGFAPTTEIVSNPDMLYIALGIIGATVMPHNLYLHSGIVQTRDYGHTTAEKREAIRYATLDSTIALTFALVINASILILAAASFHATGHTGVEDLDKAHALLNPLLGSAIAPALFAIALLCCGLNSTITATMAGQIVMEGFIDIRLKPWIRRAITRFVAIVPAAIVTILYGSQGTTELLILSQVVLSLQLPFAVIPLVIFTAQKKKMGSLAAAPWVTFLAAITAAIIVVLNLKLIYDFFTGAPI
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEUD_NITWN
Sequence: MDKFTTLEGVAAPLKIINVDTDMIIPKQYLKTIKRTGLGRGLFSEQRYRDDGSENPDFVLNKSAYRNARILVAGDNFGCGSSREHAPWALLDFGIRCVISTSFGDIFYNNCFKNGILPIRVTQADLDKLFDDAERGANATLTIDLANQEIRGPDGGTVKFEIDAFRKHCLLNGLDDIGLTMEKKAAIDSYEDKAKRERAWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RUVB_BACC2
Sequence: MDERLLSGESAYEDSDLEYSLRPQTLRQYIGQDKAKHNLEVFIEAAKMREETLDHVLLYGPPGLGKTTLANIIANEMGVNVRTTSGPAIERPGDLAAVLTALQPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATTRAGALSAPLRDRFGVLSRLEYYTVDQLSAIVERTAEVFEVEIDSLAALEIARRARGTPRIANRLLRRVRDFAQVRGNGTVTMEITQMALELLQVDKLGLDHIDHKLLLGIIEKFRGGPVGLETVSATIGEESHTIEDVYEPYLLQIGFLQRTPRGRIVTPLAYEHFGMEIPKV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: QUEF_PHOPR
Sequence: MSKYKDAKELAGLTLGQKTDYIDQYDASLLQPVPRSLNRSDLNLGESLPFTGYDIWTLYELSWLNSKGLPQVAIGEVRLPASSPNLIESKSFKLYLNSFNQTRFDSWQQIADTLQKDLTACAGQEVDVTIQPLEDFTDQTVINFAGNCIDEQDIEINSYDFDAQYLKDAAEGEIVTEDLHSHLLKSNCLITNQPDWGSVKISYKGKQINREKLLRYLVSFRNHNEFHEQCVERIFTDIMKFCQPELLTVYARYTRRGGLDINPYRTNQGKTPSDNFRLARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLI_THEVO
Sequence: MKFSLVTDAFEKMSKTTKRTELTEILVELLKSADEDLQSLVYLIEGKLAPDYQGIETQMSDKLIIKALSIVSNIPEEAVSETYSKLGDIGSVAREIAAKKNMRSLVNEDLTVKYVHDTLMRMAKTSGSGSTKARIDAYVDLALSGTPADLMYITRIITGKLRIGVSDATILDAIILAFSDEKYSEEIENAYNFHPDLGYIAVQLRLGNLESVINMGPTPMVPFKVMLAERLRSVDEIVQKMNGKCAFEYKYDGMRTEIHIVDEKVRLFSRGNEETTGQFPDIVKSAKETFHVSSVILDGEAVPYNPETGELYPFQVISQRRGRKYDLDKVSNEIPITVFLFDIVYINGKDLSKTPYAERRRILEGLFKENDNFKLAKRIVSSDTGTITKFFNQAIEDGCEGLVAKSMADDSYYKAGARGWLWIKLKRDYQAQLWDTIDLTVVGAFMGHGRRSGTYGALLLATYNEKNDTFETVCKLGSGFTDDVLFSLPKRFAEFVSKEKPARVVSTIEPDVWIYPSIVMEIIGAEITISPVHTCAFGIIEKDAGLSIRFPRFTGKWRDDKKPEDSTTTQEIIEMYKEQKKTLTEEKS
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: PTH_SHESH
Sequence: MSNIKLIVGLANPGDKYAQTRHNAGAWYVQELARVCGATLVADSKYYGLTARVTLHGKDVRLLIPSTFMNLSGKSVGALANFFRIEPEEILVAHDELDMQPGVAKFKLGGGHGGHNGLKDIIAKLANNKGFYRLRIGIGHPGDKNQVSNYVLGKAPASEQTLIETVIDEAVRSTELLFNEDMAKAMHRLHSFKG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBSAG_HBVH2
Sequence: MGAPLSTARRGMGQNLSVPNPLGFFPDHQLDPLFRANSSSPDWDFNTNKDNWPMANKVGVGGFGPGFTPPHGGLLGWSPQAQGILTTSPPDPPPASTNRRSGRKPTPVSPPLRDTHPQAMQWNSTQFHQALLDPRVRGLYFPAGGSSSETQNPVPTIASLTSSIFSKTGDPAMNMENITSGLLGPLLVLQAVCFLLTKILTIPQSLDSWWTSLNFLGVPPGCPGQNSQSPISNHLPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLLPGSTTTSTGPCKTCTTLAQGTSMFPSCCCTKPSDGNCTCIPIPSSWAFGKYLWEWASARFSWLSLLVQFVQWCVGLSPTVWLLVIWMIWYWGPNLCSILSPFIPLLPIFCYLWASI
What is the function of this protein?
The middle envelope protein plays an important role in the budding of the virion.  It is involved in the induction of budding in a nucleocapsid independent way.  In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
What are the official names of this protein?
Large envelope protein, L glycoprotein, L-HBsAg, LHB, Large S protein, Large surface protein, Major surface antigen.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus major surface antigen family.
What are the subcellular locations of this protein?
Virion membrane.
Protein: DLGD_ECOUT
Sequence: MKVTFEQLKAAFNRVLISRGVDNETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTEDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL
What is the function of this protein?
Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
What are the official names of this protein?
2,3-diketo-L-gulonate reductase, 2,3-DKG reductase, 3-dehydro-L-gulonate 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_PSECP
Sequence: MSPMARTAPVPAATDPAIIRNFCIIAHIDHGKSTLADRMLQSTGVVQARDMKAQYLDRMDIERERGITIKSQAVRMPWEVEGVSYALNMIDTPGHVDFTYEVSRSLAACEGAILLVDAAQGIEAQTLANLYLAMENNLTIIPVLNKIDLPAAQPEKYAAELASLIGGDPEDVLRVSGKTGVGVEALLDKIVRDLPAPEGNPDAPARAMIFDSVYDTYRGVVTYVRVVDGMLHPRERIQMMSTRASHELLEIGVSSPEPTPSKGLGVGEVGYLITGVKDVRQSKVGDTVTNLAKPAAQSLPGYADAKPMVFSGLYPLDGADYPVLRDALEKLMLNDAALVYEPETSAALGFGFRVGFLGLLHLEITRERLEREYNLDLISTAPNVEYEVTLEDKKVVRVTNPSEYPTGKIAEVREPMVSATILAPNEFVGAIMELCQSRRGVMGGMDYLSEDRVEIRYRLPLAEIVFDFFDILKSKTRGYGSLDWKADGEQVADLVKVDIMLQGEQVDAFSAITHREKAYAYGVMMTGKLRELIPRQQFEVPIQAAIGSRIIARESIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGTVEVPQEAFIAALTTDESKDKAKKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CINAL_FERNB
Sequence: MKKAIILAIGNELVEGLIVDTNSKYLAQRLKEFGYYIVRTETLPDNFDIMVLRIKEAIKDADLIITSGGLGPTEDDLTREAVAHSIGRKLLKNEAIAQELINRAIKYYGKAPESVVKQAFVIENAEVIDNKVGTAPGQMLKYDGKIIILLPGPPVELIPMFESILEKLKTNDSLYTRRIKTIGIPEAVLMDEYKDILYSNSRITIATMASYERGVEVRFTGPIEIKDEIDYVVNTLLPKLGESVYALDDKEMHDVVYELLVKNNYTVSFAESCTGGLISSTFVDIPGVSSVFKGSVVAYSNEAKIEILGVSKETIEKFGAVSEECVIEMAQGAKKIFNSNFSVAVSGIAGPSGGSEKKPVGTVCIAVCSPNGINSATYNLRGDRQMIRKRSTLIAFDMLRRGIIKCQG
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: RDRP_ROTWI
Sequence: MGKYNLILSEYLSFVYNSQSAVQIPIYYSSNSELEKRCIEFHAKCVDSSKKGLSLKSLFEEYKDVIDNATLLSILSYSYDKYNAVERKLVNYAKGKPLEADLTANEIDYENNKITSELFQSAEEYTDSLMDPAILTSLSSNLNAVMFWLERHSNDVADANKIYKRRLDLFTIVASTINKYGVPRHNEKYRYEYEVMKDKPYYLVTWANSSIEMLMSVFSHEDYLIAKELIILSYSNRSTLAKLVSSPMSILVALIDINGTFITNEELELEFSDKYIKAIVPDQIFDELQEMIDNMRKAGLVDIPRMIQEWLVDCSLEKFTLMSKIYSWSFHVGFRKQKMIDAALDQLKTEYTEDVDGEMYNEYTMLIRDEIVKMLEVPVKHDDHLLRDSELAGLLSMSSASNGESRQLKFGRKTIFSTKKNMHVMDDIAHGRYTPGVIPPVNVDRPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKMLSYAKHTREYAEFYSQSNQLLSYGDVTRFLSSNSMVLYTDVSQWDSSQHNTQPFRKGIIMGLDMLSNMTNDPKVVQTLNLYKQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANSIANLALIKTVLSRIANKYSFITKIIRVDGDDNYAVLQFNTDVTKQMVQDVSNDVRYIYSRMNAKVKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAILYSNYIVNKLRGFETDREFILTKIIQMTSVAITGSLRLFPSERVLTTNSTFKVFDSEDFIIEYGTTNDEVYIQRAFMSLSSQKSGIADEIASSQTFKNYVNKLSDQLLISKNVIVSKGIAVTEKAKLNSYAPVYLEKRRAQISALLTMLQKPVSFKSNKITINDILRDIKPFFVTSEANLPIQYRKFMPTLPNNVQYVIQCIGSRTYQIEDSGSKSSISKLISKYSVYKPSIEELYKVISLREQEIQLYLVSLGVPPVDASTYVGSRIYSQDKYKILESYVYNLLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEIINYAIKNGAWISLFCNYPKSEMIKLWKKMWNITALRSPYTSANFFQD
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2.  The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation.  To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates.  VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication.  Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, Protein VP1.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).
Protein: 3BP5_RAT
Sequence: MDTALKRSRSEEPVELPPPAREAEEKEEEEERMEQGLEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELAKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGVGAEGSITSVENLPASKPEPDAISVASEAFEDDNCGNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLSSTSAGGGRSRSQSSTSLEGQALETRMKQLSLQCSKGREGIIADIKTVQIG
What is the function of this protein?
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25.  Inhibits the auto- and transphosphorylation activity of BTK.  Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells.  May be involved in BCR-induced apoptotic cell death.
What are the official names of this protein?
SH3 domain-binding protein 5, SH3BP-5, Vascular endothelial cell-specific protein 18.
What is the protein family that this protein belongs to?
Belongs to the SH3BP5 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein. Mitochondrion. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes.
Protein: MUKF_SALPA
Sequence: MSEFSQTVPELVAWARKNDFSISLPVDRLSFLLAVATLNGERLDGEMSEGELVDAFRHVSDAFEQTSETIGVRANNAINDMVRQRLLNRFTSEQAEGNAIYRLTPLGIGITDYYIRQREFSTLRLSMQLSIVAGELKRAADAAAEGGDEFHWHRNVYAPLKYSVAEIFDSIDLTQRIMDEQQQQVKDDIAQLLNKDWRAAISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDKNRVFAQRLRQSVQTYFDDPWALTYANADRLLDMRDEEMALRDDEVTGELPPDLEYEEFNEIREQLAAIIEEQLAIYKTRQTPLDLGLVVREYLAQYPRARHFDVARIVIDQAVRLGVAQADFTGLPAKWQPINDYGAKVQAHVIDKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: SELO_PHOPR
Sequence: MKTLSQLVFNNTYSELPTTFGTAVIPQPLSDPFLVSVNPQVAEMLELDPLEAKTRLFINSFTGNKELAGTAPLAMKYTGHQFGHYNPDLGDGRGLLLGEVLTSTNAKWDIHLKGSGKTPYSRQGDGRAVLRSSIREYLGSAALNGLGIKTTHALALLGSTTLVSREKMERGATLIRVAESHLRFGHFEYLFYTHQHSELKLLADYLIKHHFPDLLTTESEQEDKQTASPNQHHNIYASMLTRIVELTAQLIAGWQSVGFAHGVMNTDNMSVLGLTFDYGPFGFLDDYNPDYICNHSDYSGRYAFNQQPSIALWNLSALGYALTPLIDKEDVDAILNRYHLTLQRDYSARMRNKLGLIEKREEDTVLFSSLFELLQSQMVDYTLFFRTLSSISATDLSVTSLPNSIERFDDLFTCTQPLEKWLKAYAVRLSFENDTSEKNGDTLRLTQMKLHNPKYILRNYLAQQAIDKAEDGDFTMIDELLQVLSSPFDEHLEFNQFADKPPYWGKKLEISCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: THIL_HALSA
Sequence: MDERAALELVGGLVSRAGDDAAVVGDTALTIDMLHDATDFPSGTTRYTAGWRSVGASLSDVAATGATATAAVAAYGAPGFDDDELAAFVTGARDVCTAVGAEYVGGDLDGHSEFTVATAAIGDADHRVTRSGARPGDSVVVTGSLGRSAAAMALFDAGDTERANDLFQFMPRVAAGRVLGAHATAMMDASDGLARSLHQLAAASDCGMAVDSGRLPVADALAEVTADPVERAVSFGGDFELVAAVPPERVEAARAAVPGSLSVVGRVTAAADGVRLDGDALADDGWTH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
What are the official names of this protein?
Thiamine-monophosphate kinase, TMP kinase, Thiamine-phosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-monophosphate kinase family.
Protein: LFTR_LEGPA
Sequence: MAYDSDYTFPDPETSDKQGLLAIGGVLTPKRVLQAYSQGIFPWYEPGNPVLWWSPNPRLILIPNEFKISRSLKKTLKKPFKLTVDTAFQRVISYCATCSDRTNKTWITSEMIETYTQLHEMGYAHSFEIWDGSELVGGLYGISLGHAFFGESMFHTITDASKVALHFLCSIMQSWNFDFIDCQLPTLHLMRLGAKIISRKEFLHMLQETLKYPDKKGNWSVD
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.