PharMolix/UniProtQA huggingface dataset:
Protein: Y077_BIFAA
Sequence: MVDGMSDMGTTELGAASTPEQARAAFRDGLVRPTCGIAQGYAQANLMILPKEQAFDFLLFAQRNHKPCPLLEVMEPGVTAPVTAPGADIRTDVPLYRVWKRGELVAEVPDIREYWRSDLVTFVIGCSFTFEFPLMEAGVPVRHITAGRNVPMYDTSIECRSAGAFHSTMVVSMRGIPSTQVADACRISGYYPSVHGAPVCVGDPSAIGIDDIMHPDYGDAPVLEPGDVPVFWACGVTPQAAVMASKPEFAITHAPGHMFITSKRDLEYMV
What are the official names of this protein?
Putative hydro-lyase BAD_0077.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: CYC13_CLITE
Sequence: DTTPCGESCVWIPCVSSIVGCSCQNKVCYQN
What is the function of this protein?
Probably participates in a plant defense mechanism.  Not active against Gram-negative bacterium E. coli ATCC 700926 or Gram-positive bacterium S. aureus ATCC 12600 up to a concentration of 100 uM under low-salt conditions (PubMed:27007913).
What are the official names of this protein?
Cliotide T13, Cyclotide cT13.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: GSA_ACIB3
Sequence: MSLSPKQEQLFKQASKHIPGGVNSPVRAFNGVGGTPVFIEKAKGAYLWDVDGKRYVDYVGSWGPMILGHAHPDIIKAVQTAAEDGLSFGAPTVHETTLADIICEIMPSIELVRMTNSGTEATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGLLTKGEGEPTSKGVPADFAKHTLTLPYNDIAALKECFAKFGHEIAGVIIEPVAGNMNMVKPIDGFLQAIRDVCDEYKSVFIIDEVMTGFRVALGGAQSVYNVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQAGTLSGNPLAMRAGIEMFKHLRQPDFYSKLSAQLEKLLAGLQAAADEAGIPFKTQQAGAMFGLYFTDQEDITSFDSMLACDIEAFKKFFHGMLKRGVNLAPSAFEAGFISSAHSDEDIEFTIQAAKETFAEMK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G1PDH_METPE
Sequence: MSADGIKLLRTPGFDKSKWMQLPRDVVIGHNALDQFPAVCQDLKIGRSVMLFAGKSTMQVAGNRIEELLAPSFDISTFLARELTPESMKEGEEAACGVDLIIGVGGGRVIDTAKIVSFNLDLPFISVPTAASHDGIASGRASLQTSEGSASLTAHPPLGVVADTGIIAAAPHRLLAAGCADIISNYTAILDWELSNRLRGEPISEYAITLSRMTAEILMKNAPMIRPHQEESAWMVVKALVSSGVAMAIAGSSRPASGGEHKFSHALERLAPGKALHGEACGIGTIIMMYLHGGDWRGIRTALQQIGAPTTPAELGIPDEVAVAALMMAKTIRPERFSILDSGLTEESATALIRLLYGE
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M235_CONTE
Sequence: MMSKLGALLIICLLLFPLTAVPLDGDQHADRPAERLQDDISSKHHPMFDAVRGCCHPSTCHMRKGCSRCCS
What are the official names of this protein?
Conotoxin TxMMSK-05.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MSBA_PSET1
Sequence: MDQSTTQIYKRLISYVGAYRTVAIVAIIGMIGYSGMDALFIQLMKPFIDEGLNERNADVLKYAPFVVIALVIGRGVFNFMSSYCLSYVGSQVVRSLRQELFEHILHLPVSFHDKNSTGDLISKITFDTEQVQQAITKALLIVVREGAFVVFLLAVMFYTSWQLSLIFLVIIPLVAVIVTVVSKRFRHISKSIQSAMGQVTRSSEQMLSGHKVIHGFGGQNQEIDQFSKVNNHNRQQRIKMDATKALSVSIIQVLAASAMAVILWVVSMPSMIDTISSGDFVVLISSMMMLLRPLKQLANVNSDMQRGVSAAQSVFLILDEEVEKDTGTVSVDKVKGLIEVKNVTFKYPTKDEPVLNNLSLTIKAGESIALVGRSGSGKSTISNLLPRYYDLEAPSEILLDGIALHDYKLTDLRRQFALVSQQVVLFNDSIANNICYGLQREISQQELEKVAKQAHVWEFVKDLPEQLNTMVGENGVMLSGGQRQRIAIARAILKDAPILILDEATSALDTESEKLIQQALEALMKDKTSIVIAHRLSTIENSDRIYVIDNGSVIESGDHLSLLANNGTYSALCKMQFGEQG
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HSLV_PECCP
Sequence: MTTIVSVRRNGQVVIGGDGQATLGNTVMKGNVRKVRRLYHDRVIAGFAGGTADAFTLFELFERKLELHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADENASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELGARDIVEKSLGIAGDICIYTNQFHTIEELASKA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFQ_CLOB8
Sequence: MVNKQQNNLQDIFLNNARKNKIQIIIHLVNGFQLKGTVKGFDNFTVILDCDNKQMLIYKHAISTITPTKPILFADNEYETT
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: RL331_STAAR
Sequence: MRVNVTLACTECGDRNYITTKNKRNNPERVEMKKFCSRENKQTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: C1QB_MOUSE
Sequence: MKTQWGEVWTHLLLLLLGFLHVSWAQSSCTGPPGIPGIPGVPGVPGSDGQPGTPGIKGEKGLPGLAGDLGEFGEKGDPGIPGTPGKVGPKGPVGPKGTPGPSGPRGPKGDSGDYGATQKVAFSALRTINSPLRPNQVIRFEKVITNANENYEPRNGKFTCKVPGLYYFTYHASSRGNLCVNLVRGRDRDSMQKVVTFCDYAQNTFQVTTGGVVLKLEQEEVVHLQATDKNSLLGIEGANSIFTGFLLFPDMDA
What is the function of this protein?
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.  The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
What are the official names of this protein?
Complement C1q subcomponent subunit B.
What are the subcellular locations of this protein?
Secreted.
Protein: U507_CANAL
Sequence: MTSTNKSISHLPILHNPFLNCLFNNPQYFKSPLKGVVDELQSNHTNFTILVPPAHVLNEYYDPTTESSNSKTLLKELCYNNEDFIRSHIINTASPVSSTITPISKEQSVIYNTLNNKQILIKNRIIYTGKGFRRSLKLKTLSIQYFSSFCDYFPKRSKFMIIYIESTLFGGIPPRKMLPPLPEVRETNKTDKDIDSVTFEKLLRSFPLLSKAVSDKFYRLFHHNNYQFRVLRYKNRKKLSHIKLEFQKILQEAFSIISDSVNVDNPNSEQTYNLINHIISMYPGIDLNKLVHEYVELNLYDVLWSQLIFQFNCPNDDKEAYDPEAILILTKEKYEKLSCLSLNQLDIPVNKPWLMNELHERISLGVQEFEKLADSSIMNSAAKTQVVYSTFRILTQRKNGNIDPVINADTLIGLLIMVMVHSKIENIEAHIYYIKHFNSIDNTNDGQFNYIMSNLDAVLFHFSKKESGYLDLIENSKKNYEIWNAIKNNDLEKVESIIELVNNEYPETELPENHFLKSKNINGESCLMFAIKTKRYEIYDCLINSNPNWIPIDSILFEKNVMTNQNLLMCALIEETDYKIIDDLVDIILNNATLEEQTMYFNMTDISGRSVGHYLFHNYKLISKIGHLIDWEKKDNNSHTPLFSLCRCYDHPEYVELIRAGFNCVYKKYGETGVDYDKHVDKSGNTLLHVLLKGIPESKMLSNSNNLVNVNQLNQRCLSPLMVYVKYNRLENLKEILHDSRLDFLGEDFKNYYNVFDYLSFSALKSTKSENFQNIENAVFNYYLQNYFPRHATENVAALNAKYDGGKKDWLIFFKNGDGFCNYKSLRNIKQILYLIKLKQPLSTFPSEESFWKNYGFGISTSPMFHKVRINRLIDDFNLLFEGLTFQESINQSEFFKTFLTEYTKETSIFESKQRIGEQLDFDKQSLGEVTYKLNQIQEIEYFLEYSLNNFQKYAYLFARLAKLVCIGDSKQVDCRNVLDTIMYRFNKTTVFDDIFTYSEVNNQAGTLGVAREYFYWIQMHGDELLHSIQKLVSDINSWKQMYYSICHINSELKLMEPHNTVSQESQDNSNGQELLSRRDSSLSINPIPEEELEDDNLGFLSNFVGTSKKARYKKLVVEKSEIVKNIMKLNLEIKWSHELIAAEISDFLKFRTEFLRFGIKRYISEEIKSLKQRSTELSKYVFLVRKDK
What are the official names of this protein?
UPF0507 protein C2_02840C_A.
What is the protein family that this protein belongs to?
Belongs to the UPF0507 family.
Protein: RL24_LAWIP
Sequence: MQQIRIHKNDKVMVIAGKDKGKIGKVLKVCHKHNRILVEKVNIVKRHVKPNPYRREHGGIIEKELPIVTSNLMIICSSCTSPTRVHYRYSESGKKLRICKKCNESL
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: Y085_ARCFU
Sequence: MVARTIATFAGSTALTIKPFLVNLPVVICLAAYLVSQVFCLAGFCPDYLAELHLCTFFTFFTSFLLVPLAIFTLRKDGNFLRKRAVFTSYSCVYPPFRLGNPTCFYSYHWFLIHIPESLWLVNNGFGLRATCRLSSRRSQR
What are the official names of this protein?
Uncharacterized protein AF_0085.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LPXA_PSEPW
Sequence: MNSIDPRAIIDPSAKLADGVEVGPWSIVGPDVEIGEGTVIGPHVVLKGPTRIGKHNRIYQFSSIGEDTPDLKYKGEPTRLVIGDHNVIREGVTIHRGTVQDRAETTLGDHNLIMAYAHIGHDSVIGNHCILVNNTALAGHVHVGDWAILSGFTLVHQYCHIGAHAFSGMGTAIGKDVPAFVTVFGSPAEARSMNFEGMRRRGFSDEVIHALRRSYKIVYRQGLTVEEAVKELDELAGKHPEVDLFRQSIVNSARGITR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE1_HPVR7
Sequence: MADPKGSTSKEGLGDWCILEADCSDLENDFEQLFEQDADSDVSDLLDNGELEQGNSLELFHQQECKQSEEQLQILKRKYLSPKAVAQLSPRLELMSLSPQQKSKRRLFAEQDSGLELSLNNEAEDNAPEVEVPALDSGPVDEGGTGDVDIDYLALLRSSNRKATLMAKFKDAFGVGFNELTRQFKSYKTCCNHRVLAVYAVHDDLFESSKQLLQQHCDYIWVRGIAAMTLYLLCFKAGKNRGTVHKLLTSMLNVQEQQILSEPPKLRNTAAALFWYKGGMGSGAFTYGKYPDWIAQQTVLGHQNAEASTFDFSVMVQWAFDNNHVDEADIAYQYARLAPEDSNAVAWLAHNSQAKFVRDCAAMVRFYKNLQMREMSMSEWIYTRINEVEGEGHWSSIVKFLGYQGVNFIMFLAALKNFLHAVPKQNCILIHGPPNSGKSSFAMSLIKVLKGRVLSFVNSRSQFWLQPLGECKIALIDDVTDPCWLYMDTYLRNGLDGHFVSLDCKYKAPVQTKFLPLLLTSNINVHEETNYRYLHSRIKGFEFPNPFPMKSDNTPQFELTDQSWKSFFERLWTQLELSDQEEEEEGEHGETQRAFQCSARSANEHI
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: EIF3I_DROVI
Sequence: MLQGHERSITQIKYNREGDLLFSSSKDQKPNVWYSLNGERLGTYDGHQGAVWCLDVDWESRKLITGAGDMTTKIWDVEYGTVIASIPTKSSVRTSNFSFSGNQAAYSTDKAMGQNCELFIIDVRNADSSLSEQEPTLRIPMVESKITSMLWGPLDETIITGHDNGNIAIWDIRKGQKVVDSGTDHTAGINDMQLSKDGTMFVTASRDTTAKLFDSESLMCLKTYKTERPVNSAAISPILDHVVLGGGQDAMEVTTTSTKAGKFDSRFFHLIYEEEFARLKGHFGPINSLAFHPDGKSYASGGEDGFVRVQSFDSTYFENIFE
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit I, eIF3i, Eukaryotic translation initiation factor 3 subunit 2, TRIP-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit I family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_DICTD
Sequence: MKIALDAMGGDYAPIETVKGALEAIKESNISVVLVGKEEEIKKILQDYHYNESKIEIVHAEEVIEMHEHPAFAVKEKEDSSIVKAIKLLKEKKVDGVVSAGNTGAVMSSALLYLGRIRGIKRPAISTLIPTLTQIPSIILDIGANVDCKKEYLEQFALMGKVYMEEIFNVKNPKIALLNIGEEEGKGNQLVQETYTLLKNNPLFNFIGNVEGKDLFKGTANVIVCDGFVGNVAIKTAEGVAETLFDLLSSEIKSSLWSIILGLLLKPKFKNVKKKLDYSEFGGAPLLGVDGTVIISHGRSKAKAIKNALKVAEKMVKLEVNKKILEGLNKITDRGD
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: HC2C_MEGCR
Sequence: DFGHSKKIRKNVHSLTAEEQNSLRRAMDDLQDDKTRGGFQQIAAFHGEPKWCPRPEAEKKFACCVHGMAVFPHWHRLLTVQGENALRKHGFTGGLPYWDWTRPMSALPHFVADPTYDDSVSSLEEDNPYSHGHIDSVGHDTTRAVRDDLYQSPGFGHYTDIAKQVLLALEQDDFCDFEVQFEIAHNSIHALVGGNEPYGMSTLEYFLYDPIFFLHHSNTDRLWAIWQALQKYRGKPYNTANCAIVRHDTYRKPLQPFGLDSVINPDDETREHSVPRDVFNYKDDFNYEYESLNFNGLSIAQLDRELQRIKSHDRVFAGFLLHEIGQSALVKFYVCKHHVSDCDHYAGEFYILGDEAEMPFAYDRVYKYEISQALHDLDLHVGDNFHLKYEAFNLNGGSLGGVDLSQPSVIFEPAAGSHTA
What is the function of this protein?
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
What are the official names of this protein?
Hemocyanin 2-c chain, KLH2-c.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: FIB_STAAN
Sequence: MKNKLIAKSLLTIAAIGITTTTIASTADASEGYGPREKKPVSINHNIVEYNDGTFKYQSRPKFNSTPKYIKFKHDYNILEFNDGTFEYGARPQFNKPAAKTDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVR
What is the function of this protein?
Extracellular fibrinogen-binding protein that plays an important role in virulence.  By interacting with the alpha chain of fibrinogen and its derivative fibrin, enhances a non-functional interaction between fibrinogen and platelets and is responsible for repression of fibrinogen-dependent platelet aggregation.  In addition, assembles a fibrinogen protective shield around the bacteria which results in impaired phagocytic clearance by the host.  Mechanistically, interacts with host complement C3b deposited on the surface of the bacterium via its C-terminal and then recruits fibrinogen via its N-terminal.
What are the official names of this protein?
Fibrinogen-binding protein.
What are the subcellular locations of this protein?
Secreted.
Protein: DXR_CLOPS
Sequence: MKRISILGVTGSIGTQTLDVLRFHKEDFELVGITANRNIELTMDIIKEFSPKYVAINHEESYKKLVDLVKSEGLKCEVIYGMEGLVKVATLDEIDIVVTSVVGMIGLKPTVEAIRKGKNIALANKETLVVAGELVMREAKENGVKILAVDSEHSAIFQSLQGNAHNKIDKILLTASGGPFRGFTIKDLKSVTPERALKHPKWNMGQKISIDSSTLMNKGLEVIEAHWLFDCPYKDIEVVVHPQSIIHSMVQYTDGAVIAQLGVPDMKLPIQYALNYPNREGNISEKLDLFKIRELTFEKPDLDTFKCLKLAYEAGEKGKLMPTILNGANEVCVELFLNKKITYLQIPEIIEECMNTFDYNKEVTLDNVINLDKEVRQYIYEKYN
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: RPOC_GEOSM
Sequence: MEDIFNFFDKPKDPLHFSSIKISISSPDKIRERSFGEVKKPETINYRTFKPERDGLFCAKIFGPTKDYECNCGKYKRMKHRGIVCEKCGVEVIPSKVRRERLGHIDLATPVAHIWFLKSLPSRIGNLMDITLKDLEKVLYFEAYVVTDPKETGLAFGTVFSEDQYQKALEEYSYGFEAGMGAAAIRTCLTSMDLDQLSEQLRIEMQEATSEAKRKKTAKRLKVMEAFKNSGNKPEWMILECIPVLPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLMELQAPEVIIRNEKRMLQEAVDALFDNGRRGRAIAGPNKRPLKSLSDMLKGKSGRFRQNLLGKRVDYSGRSVIVVGPELRLHQCGLPKKMALELFKPFIYNKLEERGFVTTIKSAKKMVEKEKPEVWDVLEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCTAFNADFDGDQMAVHLPLSVESQVEARVLMMSTNNILSPAHGKPIIVPSQDMVLGIYYMTREKHFALGEGKIFASADEVNIAWDAGEIHLQARIKVRMKNLVSDEKPTLIETTTGRVLLRDILPDAVPYATINKVMTKKELSNLVDVCYRLAGNKETVILADKLKAIGFRYAAKAGISISINDMVIPEGKPAIITRATEEVQEIQNQYTEGLITDGERYNKVIDIWAKSTEDIAKEMLDNLSRDTILDPEGKEVKVPSFNAIHMMADSGARGSAQQIRQLAGMRGLMAKPSGEIIETPITANFREGLTVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDAIITEADCGTIDGLTVSSLTEGGEVIEHIGDRILGRVALDDILDPVTGDVLVPANEEIDENLVARIEAAGLEKVKIRSVLTCESRRGICAKCYGRDLARGHLVNRGEAVGVIAAQSIGEPGTQLTMRTFHIGGTASRRAEQTALEARNEGFAKFININYVTNSEGHHIVMNRNGELAIVDETGREREKYGVVYGAKIKVSPQEKVTQGQSVAEWDPYTMPILTEIAGRVKFGDVIEGVTMEEQVDEVTGLSRKVIIETRDADKRPRITIKDESGKTAKIGDSLLARYYLPVGSNINVLEDTEVNAGDVIAKIPRETTKTKDITGGLPRVAELFEARKPKDFAVITEIDGVVAFGKDAKGKRKVLVTPELGEPKEYLIPKGKHISVHEGDHVRAGEALMDGSSNPHDILRVLGQKELAKYLVDEVQEVYRLQGVKINDKHIETIVRQMLRRVRVKDVGDTNLLIDDQIERWVFEEENEKAMDKGGRPATAESLLLGITKASLSTESFISAASFQETTKVLTQASIEGKIDSLRGLKENVIMGRLIPAGTGLALYRNLRMVAEEPVIIPEPVEPEDEEIYEEEA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: STX1B_HUMAN
Sequence: MKDRTQELRSAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVLASSIGGTLGL
What is the function of this protein?
Potentially involved in docking of synaptic vesicles at presynaptic active zones.  May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity).
What are the official names of this protein?
Syntaxin-1B, Syntaxin-1B1, Syntaxin-1B2.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
[Isoform 1]: Membrane; Single-pass type IV membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma- tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.
Protein: CA13B_CONLT
Sequence: FDGRNAAPSDKASDLISLAVRGCCSHPACSGNNPYFCGGKR
What is the function of this protein?
Lt1. 3-I (C1-C4; C2-C3): This isomer inhibits GABABRec-coupled Cav2. 2/CACNA1B but has no activity on nAChRs.
What are the official names of this protein?
Alpha-conotoxin Lt1.3 b.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RPB5_ASFM2
Sequence: MAMQKLFTYIYEFIEYRKMVLLEEKVPYDKFVQMVFNTGFFRINAETLNHGIVSVFIFGANGKYVHHGGDMRTLLTNTLNEKKQYEELILIVDKPILGKKNILDIIVEQRAANPTVVINIYPYHLFCINIPKVSAIPKHKLITQEEAQEFLGREYLQPQDLMQISASDPPVVWLGGRPGDFVQIERPSETAMHAVVIRFITKSKI
What is the function of this protein?
Component of the DNA-directed RNA polymerase (RNAP) that catalyzes the transcription in the cytoplasm of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase RPB5 homolog, RPB5 homolog.
What is the protein family that this protein belongs to?
Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion. Note=Found in association with viral nucleoid.
Protein: PDXK_SHIDS
Sequence: MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRALQERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIFELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMQVAVVSADSVNVISHSRVKTDLKGTGDLFCAQLISGLLKGKALNDAVHRAGLRVLEVMRYTQQHESDELILPPLAEA
What is the function of this protein?
B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i. e.  PNP, PLP and PMP.
What are the official names of this protein?
Pyridoxine/pyridoxal/pyridoxamine kinase, PN/PL/PM kinase, B6-vitamer kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxK subfamily.
Protein: RAS2_DROME
Sequence: MQMQTYKLVVVGGGGVGKSAITIQFIQSYFVTDYDPTIEDSYTKQCNIDDVPAKLDILDTAGQEEFSAMREQYMRSGEGFLLVFALNDHSSFDEIPKFQRQILRVKDRDEFPMLMVGNKCDLKHQQQVSLEEAQNTSRNLMIPYIECSAKLRVNVDQAFHELVRIVRKFQIAERPFIEQDYKKKGKRKCCLM
What is the function of this protein?
May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking.  May interact functionally with ROP protein.  Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
What are the official names of this protein?
Ras-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: NS8_SARS2
Sequence: MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI
What is the function of this protein?
Plays a role in modulating the host immune response (PubMed:31986261, PubMed:35343786, PubMed:36689483).  May act as a secreted virokine by mimicking interleukin-17A (IL17A), and thereby binding to the IL17RA receptor, leading to activation of the IL17 pathway and increasing secretion of pro-inflammatory factors (PubMed:35343786, PubMed:36689483).  Contributes to the cytokine storm during SARS-CoV-2 infection when secreted by unconventional pathway (PubMed:33723527, PubMed:36689483).  May act by down-regulating major histocompability complex class I (MHC-I) at cell surface (PubMed:34021074, PubMed:35157849).  May inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 (PubMed:34177923).
What are the official names of this protein?
ORF8 protein, ORF8, Non-structural protein 8, ns8.
What are the subcellular locations of this protein?
Secreted. Note=Its mRNA is expressed in cytoplasm and the protein is secreted during a normal viral infection (PubMed:35157849). Spliced when expressed from cDNA in nucleus (PubMed:35157849). Splicing changes localization to host endosome and/or cytoplasm (PubMed:33060197, PubMed:34177923). May also localize in nucleus when fused with GFP (PubMed:34177923).
Protein: RHAD_SALPA
Sequence: MQNITDSWFVQGMIKATSDAWLKGWDERNGGNLTLRLDEADIAPFAANFHEKPRYIALSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGVVKIDSDGAGYHILWGLTHDAVPTSELPAHFLSHCERIKATHGKDRVIMHCHATNLIALTYVLENNTALITRKLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAEVLVKIYSMGGMKQTITREELVALGKRFGVTPLASAVALY
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.