PharMolix/UniProtQA huggingface dataset:
Protein: ILVC_UNCAG
Sequence: MEILHDEDVDDSILRDKTIAVMGYGAQGDAQANCLKDSGINVVIGETEILGGNKNPSWEKAKEDGFEVLPIDKAAEKGDVVHILLPDEVQPAIYENQIKPQLKAGKALCFSHGFNICFKRIVPPEDVDVIMVAPKAPGTEERKAYLEGFGVPGLVAVKQNPSGEAREVALAMTKAMHWTKAGILECTFEQETYEDLFGEQCVLCGGLVELMRNGFEVLVEAGYPPEMAYFECVHEMKLIVDLVWQGGIKRMAEVISNTAEYGMWAVGHQIIGPEVKEKMKEALKRVENGEFANEWVDEYKRGIPFLKASREKMGEHQVETVGAEIRKLFAQK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NAD(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: CXE13_ARATH
Sequence: MDSEIAADYSPMLIIYKSGRIERLVGETTVPPSSNPQNGVVSKDVVYSPDNNLSLRIYLPEKAATAETEASVKLPLLVYFHGGGFLVETAFSPTYHTFLTAAVSASDCVAVSVDYRRAPEHPIPTSYDDSWTALKWVFSHIAGSGSEDWLNKHADFSKVFLAGDSAGANITHHMTMKAAKDKLSPESLNESGISGIILVHPYFWSKTPVDDKETTDVAIRTWIESVWTLASPNSKDGSDDPFINVVQSESVDLSGLGCGKVLVMVAEKDALVRQGWGYWEKLGKSRWNGEVLDVVETKGEGHVFHLRDPNSEKAHELVHRFAGFIKGDK
What is the function of this protein?
Carboxylesterase acting on esters with varying acyl chain length.
What are the official names of this protein?
Probable carboxylesterase 13, AtCXE13.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
Protein: MENC_YERP3
Sequence: MRTATLYRYSVPMEAGVILRHQRLKSRDGLLVKLQQGELSGWGEIAPLPEFSQETLDQAQVAAECWLQHWVSGVESDDSVLPSVAFGLSCAQAELNQTLPLSADYRKAPLCTGDPDELFAVLQALPGEKVAKVKVGLYEAVRDGMIVNVLLEALPDLTLRLDANRSWSRAKADGFAKYVNPALRSRIAFLEEPCKTRAESREFAQDTGIAIAWDESVREADFQVEAEPGVAAIVIKPTLVGSLSRCQQLVQQAHQAGLVAVISSSIESSLGLTQLARLAAWLTPATVPGLDTLDLMQAQVVRPWPDSPLPLITTEQLGVVWHR
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: PSIE_ECOK1
Sequence: MTSLSRPRVEFISTILQTVLNLGLLCLGLILVVFLGKETVHLADVLFAPEQASKYELVEGLVVYFLYFEFIALIVKYFQSGFHFPLRYFVYIGITAIVRLIIVDHKSPLDVLIYSAAILLLVITLWLCNSKRLKRE
What are the official names of this protein?
Protein PsiE.
What is the protein family that this protein belongs to?
Belongs to the PsiE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QOX3_STAAS
Sequence: MSHDTNTIDSRTHEGELNKLGFWIFITAEFALFGTLFATLLTLQHGGDYAGKMTTELFELPLVLIMTFALLFSSYTCGIAIYYMRQEKQKLMMFWMIITLLLGLVFVGFEIYEFAHYASEGVNPTIGSYWSSFFILLGTHGCHVSLGIVWAICLLIQIQRRGLDKYNAPKLFIVSLYWHFLDVVWVFIFTAVYMIGMVYSG
What is the function of this protein?
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
What are the official names of this protein?
Probable quinol oxidase subunit 3, Quinol oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DYLT4_PIG
Sequence: MAGRPVPAGRQEEELAKDPGQKLSLARPPGRLPSIDETRPAGPGPASRRGSVLGPASSFSRRNSLAGAGAGPGGRRPSLGPVPPLGWRVSFSGLPLGPARRPAPSYRTEPAPGERWEAARAQRALEAALAAGLRDARYVGAEAGRLARELCDLARVHLRELSPPRYKLVCSVVLGPRAGQGVHVPSRALWDTACDGLASATVTNASLFAVATVHGLYCE
What are the official names of this protein?
Dynein light chain Tctex-type 4, Protein N22.1, Tctex-2-beta, Tctex1 domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain Tctex-type family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Present along the entire length of the flagellum, including principal and endpiece, and more predominantly in the midpiece region.
Protein: RL34_STREM
Sequence: MKRTYQPSKIRRQRKHGFRHRMSTKNGRRVLASRRRKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: ACEK_BURP0
Sequence: MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERADWHGLQRLARERITSYDDRVRECVELLEDEYDAENIDNEVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRAYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGLAATLERIVTNFQLNPPFEDLERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYVVGRIINGDRVLPFAVPIRHARAGILALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDRFIVAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKDTTREQIMAKYLLVKRHDRLGRMADTLEYSSVALPLARLDDALVRELEKEVPSLIEYEGENLVIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELMQANIFPGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRVREHFLAHHADFFDPQLWQDSKDRLLRGELPDFFAYEPALRFCIRYPERFAPGDAADGGKLAAA
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKORL_MOUSE
Sequence: MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALVLMTSSIVSVVGSLYLAYILYFVLKEFCIICVTTYVLNFLLLIINYKRLVYLNEAWKRQLQPKED
What is the function of this protein?
Involved in vitamin K metabolism.  Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress.  Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
What are the official names of this protein?
Vitamin K epoxide reductase complex subunit 1-like protein 1, VKORC1-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the VKOR family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ARGE_PASMU
Sequence: MKKIPSFLQMYSALIASPTMSSIDPHFDQSNRTLIELLANWLSSLGFRTEVIPLEGSRDKFNLLATYGEGEGGLLLAGHTDTVPFDEGRWQFDPFKLTEKDGKFYGLGTADMKGFFAFVIDAVSQLDLTRLTKPLRILATADEETTMLGARTFIQHSHIRPDCAIIGEPTSLKPIRAHKGHVGEALRITGKSGHSSDPSKGINAIELMHEATGYLMQMRDELRQKYHHAAFNIPYPTMNFGAISGGDAVNRICACCELHFDIRPLPNLRLTDLNEMLQAKLAPMFEKWGGRISLQALHDPIPGYECAHSAQVVQVVEKLLGEQCETVNYCTEAPFIQQLCPTLVLGPGSIEQAHQPDEFLSAEFIDPTRELLSKLIGQFCTG
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids.  Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
What are the official names of this protein?
Acetylornithine deacetylase, AO, Acetylornithinase, N-acetylornithinase, NAO.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. ArgE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_SYNC1
Sequence: MKEGIHPKYEAVEVKCHCGNVIQTRSTKCADMQVEVCSACHPFYTGKQKLLDTAGRIDRFRKKYAKNNK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: MPK8_ORYSJ
Sequence: MDFFSEYGDANRYKIQEVIGKGSYGVVCSAIDQHTGDKVAIKKIHNIFEHLSDAARILREIKLLRLLRHPDIVEIKHIMLPPSRRDFKDIYVVFELMDTDLHQVIKANDDLTKEHHQFFLYQMLRALKYIHTANVYHRDLKPKNILANANCKLKICDFGLARVAFNDTPTTVFWTDYVATRWYRAPELCGSFFTKYSPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDLLGTPSMDTVTRIRNEKARRYLSSMRKKQPVPFSERFPKADPAALKLLQRLLAFDPKDRPTAEEALADPYFKGLAKAEREPSCQPITKMEFEFERRKVTKEDVKELIFREILEYHPQLLKDYMNGTEKTNFLYPSALDNFRRQFANLEENGGKNGDAVPSDRKHVSLPRTTTVHSAPIPPKDHQNITSQVPQRIPGRTGRGACPVIPFENLSAMGPYNQRRVVRNPVLPPATTNLSAYAYHRKSDSSERELQQELEKDRMRYQPSEHFMDAKVVSHMSHDLRASSYYVSKAKSDVADRAALQSNMMQGIGPFNGIAAVGGNYNKVSTVQYGVSRMY
What are the official names of this protein?
Mitogen-activated protein kinase 8, MAP kinase 8, OsWJUMK1, Wound- and JA-uninducible MAP kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: Y1839_STAAT
Sequence: MNALFIIIFMIVVGAIIGGITNVIAIRMLFHPFKPYYIFKFRVPFTPGLIPKRREEIATKIGQVIEEHLLTETLINEKLKSEQSQQAIESMIQQQLQKLTKDQLSIKQITSQIDIDLEQVLQTNGNQYIESQLNNYYTKHQNQTIASLLPNQLVTFLNQHVDNATDLLCDRARNYLSSAKGTQDINDMLDTFFNEKGKLIGMLQMFMTKESIADRIQQELIRLTSHPKARTIVTSLITNEYQTFKDKPLNELLDASQFNEIAENLSVYVTTYASKQANKPVVTLMPQFVDYLEGQLSSKLANLIIEKLSIHLSTIMKKVDLRGLIEEQINTFDLDYIEKLIIEIANKELKLIMSLGFILGGIIGFFQGLVAIFV
What are the official names of this protein?
UPF0754 membrane protein USA300HOU_1839.
What is the protein family that this protein belongs to?
Belongs to the UPF0754 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYT_BART1
Sequence: MSCSISLSFPDGSKRNYPAEMTGLELAESISKSLAKKAVAYSLDGITRDLSDSLGQSGQVEIITREDSRALELIRHDCAHVLAEAVQELFPETQVTIGPVIENGFYYDFARQQPFTLDDLTIIEKKMREIIQRNKPFRKEIWSREKARRVFSEKKEFYKVELINSIPDNQDLKIYYQGEWFDLCRGPHMQSTGQIGNAFKLMKVAGAYWRGDANNPMLTRIYGTAFANENDLKAYLHMLEEAEKRDHRRLGREMDLFHFQEEGPGMIFWHQKGWKMFQNLINYMRRRLDDHQYAEVNAPQVLDRSLWEISGHWGWYKENMFKAIPAAEDLDHEHIYALKPMNCPGHVQIFKHGLKSYRDLPIRLAEFGLVHRYEPSGSLHGLMRVRSFTQDDAHIFCTDEQLAAECLSINDLILSTYADFGFKEISLKLSTRPEKRVGSDALWDHAESIMESVLKTIETKFAGQIKTSILPGEGAFYGPKFEYTLKDAIGREWQCGTTQLDFNLPERFGAFYIDKDSEKRQPVMIHRAIFGSMERFLGILIENFAGHMPLWLAPEQIVVATITSEANEYAQKITARLKAVGLSATTDLRNEKINYKIREHSLQKVPVILVCGKREAETNSVNMRRLGSPNQTLLSVEDAIKQLSNESTPPDLQRVINA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_SULIL
Sequence: MNTMSHKFVLALDEGTTSARAILFDSDLNIVNIGQYEFPQHYPQPGYVEHDPEEIWEAQMLAVKKAISKIDAKQIVAIGITNQRETTVLWDAKSGKPVYNAIVWQDRRTSPITDWLKANYFKMIKDKTGLVPDPYFSASKIKWILDNVPNVREKAERGEIKFGTLDTYLIWRLTNGKAHVTDYSNASRTMLFNINKLECDREILELLKIPESILPEVKPSSEIYGYSEALGNLIPISGDAGDQQAALFGQVAFNVGEIKATYGTGSFILMNIGNNPIRSENLLTTIAWGLEKNKATYALEGSIFITGAAVQWFRDGLRAIDVSDEIEPLASNVEDNGGVYFVPAFVGLGAPYWDPYARGLIIGITRGTTKAHIARAILESMAYQTRDVIEVMQKESGISINSLKVDGGAAKDNLLMQFQADILGIKVIRPKVMETTSMGVAMLAGLGVGLWNSLEELRSIWKVDKEFIPSMSEEKRRALYSGWKEAVKRAMGWAKVVGGQV
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RL23_SYNWW
Sequence: MRDYRDIIIKPVVTEKSMNLLADNKYTFIVDKRANKTEIKNAIENIFEVRVASVNTMNIKGKPKRMGRFEGKKPDRKKAVISLKPGHKIRLFEGM
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RS6_META1
Sequence: MSNYEIMILANPDSTLEQVSELLFSVLKKSDTKIEKLERSELAYPIHKLTRATYYLVTVKSDPQLMAELTRKLNIAKFILRSLIINLDSEKGLKPRKVKRFIPRAKNNDRSANQGDRRPFIRRNQTTDASKTEASTEATASKQSEQTTTKPRTRKVSKEQ
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: OMP1_ACTSU
Sequence: VTVYDAEGTKVQVDGSLRLVE
What is the function of this protein?
Structural rigidity of the outer membrane of elementary bodies and porin forming, permitting diffusion of solutes through the intracellular reticulate body membrane.
What are the official names of this protein?
Major outer membrane protein, MOMP.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: OBG_THEPX
Sequence: MFIDTARIYIKAGDGGNGIISFRREKYVAYGGPDGGDGGKGGDVIFIADPNLSTLLDFKYRKKYIAQNGENGRGKNQYGKNGEDLYIKVPVGTLIINDETGEIIADLVKPNQKAIVLRGGKGGRGNAKFATPTLKTPRFAESGEKGKEMWVRLELKLLADVGLIGFPNAGKSTLLASCTRAKPKIANYPFTTLTPNLGVVEHKGKSFVMADIPGLIEGAHRGEGLGHDFLRHIERTKMLIHVVDVSASEGRDPIEDFEKINEELKLYSERLLTLSQIVAANKIDIQSGKENFPAFEKEIKKRGYEVYPISALTKVGIDKLLDKTIEILSSIPVEEIKEVPEVIVYTPPEEEETLNIEVKDNTYYLSGTKIDKLLKRVNLQDEHSLRYFEMLLRKSGVIDALKEKGFKSGDTINVRDFEFEYYE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_AZOVD
Sequence: MARVKRGVIARRRHKKILKLAKGYYGARSRVFRVAKQAVIKAGQYAYRDRRQRKRQFRALWIARINAGARQNGLSYSRLIAGLKKATIEIDRKVLSDLAVNEKAAFAAIVEKAKAVLA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: GLTP_DANRE
Sequence: MALLMEHQFRQLPADKQVETRPFLEAVSHLPPFFDCLGSAVFSPIKADIAGNITKIKAVYDSNPTRFKTLQQILEAEKEMHGAEWPKVGATLALMWLKRGLRFIQVLLQSLVDGDKDDNNPNLIKVNVTKAYEMALKKYHGWIVQKLFQAALYAAPYRSDFLRALSKGREVKDEECLDKVRQFLVNFTATNDAIYEMYTKMNADLDYKV
What is the function of this protein?
Accelerates the intermembrane transfer of various glycolipids.  Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids.  May be involved in the intracellular translocation of glucosylceramides (By similarity).
What are the official names of this protein?
Glycolipid transfer protein, GLTP.
What is the protein family that this protein belongs to?
Belongs to the GLTP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBHB_ASPNC
Sequence: MSSFQVYRAALLLSILATANAQQVGTYTTETHPSLTWQTCTSDGSCTTNDGEVVIDANWRWVHSTSSATNCYTGNEWDTSICTDDVTCAANCALDGATYEATYGVTTSGSELRLNFVTQGSSKNIGSRLYLMSDDSNYELFKLLGQEFTFDVDVSNLPCGLNGALYFVAMDADGGTSEYSGNKAGAKYGTGYCDSQCPRDLKFINGEANCDGWEPSSNNVNTGVGDHGSCCAEMDVWEANSISNAFTAHPCDSVSQTMCDGDSCGGTYSASGDRYSGTCDPDGCDYNPYRLGNTDFYGPGLTVDTNSPFTVVTQFITDDGTSSGTLTEIKRLYVQNGEVIANGASTYSSVNGSSITSAFCESEKTLFGDENVFDKHGGLEGMGEAMAKGMVLVLSLWDDYAADMLWLDSDYPVNSSASTPGVARGTCSTDSGVPATVEAESPNAYVTYSNIKFGPIGSTYSSGSSSGSGSSSSSSSTTTKATSTTLKTTSTTSSGSSSTSAAQAYGQCGGQGWTGPTTCVSGYTCTYENAYYSQCL
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
Probable 1,4-beta-D-glucan cellobiohydrolase B, Beta-glucancellobiohydrolase B, Exocellobiohydrolase B, Exoglucanase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MXRA8_RAT
Sequence: MELLSRVLLWKLVLLQSSAVLSSGSPGTAAASSSVVSESAVSWAAGTQAVLRCQSPRMVWTQDRLHDRQRVVHWDLSGGPGSQGRRLVDMYSAGEQRVYQPRDRDRLLLSPSAFHDGNFSLLIRAVERGDEGVYTCNLHHHYCHLYESLAVRLEVTDDPLLSRAYWDGEKEVLVVALGAPALMTCVNREHLWTDRHLEEAQQVVHWDRQLPGVPHDRADRLLDLYASGERRAYGPPFLRDRVSVNTNAFARGDFSLRIDDLEPADEGIYSCHLHHHYCGLHERRVFHLRVTEPVFEPPARASPGNGSGHNSVPSPDPTMARGHSIINVIVPEDHTHFFQQLGYVLATLLLFILLLITVVLATRHRHSGGCKTSDRKAGKSKG
What is the function of this protein?
Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3.  Mediates heterophilic cell-cell interactions in vitro.  Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38.  Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes.  Stimulates formation of primary cilia in chondrocytes.  Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway.  Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis.  Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells.  Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK.  May play a role in the maturation and maintenance of the blood-brain barrier.
What are the official names of this protein?
Matrix remodeling-associated protein 8, Limitrin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cytoplasm. Cell projection, cilium membrane. Nucleus. Note=Primarily localizes to the cell membrane. Detected in the cilium of primary chondrocytes. Highly expressed at areas of cell-cell contact and may localize to tight junctions. Also found in the nucleus where it is detected in the soluble (as opposed to chromatin-bound) fraction.
Protein: SPEH_BACMK
Sequence: MDTMDTMGRHVIAELWDCDFDKLNDMPYIEQLFVDAALRAGAEVREVAFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDRIDPNVAAEYIAEGLNAKTRESIELPRGTGSFEIKQRETKAL
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: MPKC_EMENI
Sequence: MAEFIRSDILGTTFETTSRYANLQPVGLGTAGVVCSAYDLISEQVVAIKKMMKPFHSTSVAKRTYREVKLLRHLRHDNLINMSDIFISPLEDVYLVTELLGTDLHRLLNGKPLESKFAQYFTYQILRGLKYIHSAGVIHRDLKPGNLLINENCDLKICDFGLARVQEPQMTGYVSTRYYRAPEIMLTWQRYGSKVDLWSVGCILAEMLLGRPLFPGTDHINQFWLITDLLGNPPDEVIDRITTNNTRRVVKSMAKRNPRPLKEILPAAEDAALNLLDNLLVFDPDRRISAEQGLMHPWMAPYHDPTDEPVATEQFDWSFNDADLPLDTWKIMIYSEVLDFFQLTTNAEPSGEQSQNQSQSQSQAFTSSQDLQLASMLNLGEGELLPDFAATIDPNKFGSVDYLMDGQSLDPNSFS
What is the function of this protein?
Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.
What are the official names of this protein?
Mitogen-activated protein kinase mpkC, MAP kinase C.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
Protein: GCST_BURP0
Sequence: MTVLKTTPLHAAHRALNARMVDFGGWDMPVNYGSQIEEHQAVRTDAGMFDVSHMCVVDFTGPRVRAFFEHAIANNVAKLQTPGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQGGFGLTIAPRRDFAIVAAQGPNARAKVWDTVPCARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEIIVPATHVEALWNALAERGVRPCGLGARDTLRLEAGMNLYGQDMDESVSPLDAGLAWTVDLSAPRAFVGRDALEAHGSRAAFVGLILQKENGRAGGVLRAHQKVATPHGEGEITSGTFSPSMQESIAFARVPKDVAIGDTVHVQIRDKQLPARVVKLPFVRNGKVLAA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: SPH2_HALSA
Sequence: METNAVSLIYRCRVGERMSQHDTDGRVSVYAENIGGISQCDVTFKPGVNVLRGRNATGRTSLLNGLAGVLGGTAPVLKGDEQEAEVRLEFNGTTYDQQYTRKNGTVQAAGQPVTERRDLVDLFVCLTAENPARRAIVQDGNLRDVIMRPVDTGSIQRRIEDLQSERNRIGQRIRAIEDDLDQRTSLTSRKTTLVSDLDECDQEIEELRNQLEQFDADPEEAEEIEQALTSLEERKQELESITNRIRTQEDTREALRDEQSELQTEREAIETSEEELKRIETRLSELTSRERSLATTINDLSAIVDFNEDLVSNADSDLLRSGDAAESPVSKLNPMSETVECWTCGTEVERNRIAGRLDDLRDLVDEKRTERSEVQTEIEELRESQQELQEVIHRRDEIGQRLSEISSEIAQRDQTLESLSEEREDVHQRLSELEEFVSEREALQESELTEQYQQLSELEYQRGQLEEELSAVREELAELDRLENERDQLQAQQDEIQAELVSQRTQIRDLEESAITAFNDHMEEILDVLRYKNIARVWIERKEGAEFNSSHGGYRGGSATKFELHVVRETDEGRGYEDTVQSLSESEREVVGLVVALAGYLVHDVYEVIPMMLLDSLEAIDADRIAALVDYFADYAPYLIVALLPEDADALGGDETSVVPASFASEE
What is the function of this protein?
May play a role in replication.
What are the official names of this protein?
Smc-like protein Sph2.
What is the protein family that this protein belongs to?
Belongs to the Sph1/Sph2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAUM_METFK
Sequence: MMAEEGNRNKSTSTIEKPERRLMFKQLTRRVGVAVVGSIFGSALLRSRPAPAATVLRPPGALAEKDFQSACVRCGLCVEDCPFDILKLASWADPAPMGTPFFTARDEPCRMCQDIPCVRACPTGALNPLLTDIRKADMGVAVLVDHETCLNYKGLNCSICVRVCPIRGEAISLKPIQNERGLLQIPTVDSTKCTGCGTCEKHCVLSEAAIRVLPRELGLGVSGANSAGRTPVWK
What is the function of this protein?
Involved in electron transfer.
What are the official names of this protein?
Methylamine utilization ferredoxin-type protein MauM.
Protein: RL19_STRP8
Sequence: MNPLIQSLTEGQLRSDIPNFRPGDTVRVHAKVVEGTRERIQIFEGVVISRKGQGISEMYTVRKISGGIGVERTFPIHTPRVDKIEVIRHGKVRRAKLYYLRALQGKAARIKEIRR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.