PharMolix/UniProtQA huggingface dataset:
Protein: ILVC_BLOPB
Sequence: MANYFNTLTFIEKLKHLGKCRFMSNNEFSNGIQALLSKKVAIIGCGSQGLNQGLNMRDSGVNITYALRRESILNKQESWARATRNGFPVGTYDEIIPKSDVVINLTPDKCHTSVIRQIEPLMKHGSTLGYSHGFHIVEVGEKIRQDITVIMVAPKCPGTEVRQEYQRGFGVPALIAVHEENDTYDMGMTLAKSWAFALGSHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSILCFDYMISNGVNAAYAGKFIQCGWEVITEALKQGGITLMMDRLSNASKIRAFILSEKLKNILKPVFEKHMENILNGVFSKEMMLDWENNDSKLLKWREKTSQLPLEQAPNYQQEILEQTYFDYGILMVAIIKSGIELSFDTMIKSGIAPESAYYESLHELPLIANTIARKKLYEMNMVISDTAEYGNYLFCDKVVPLLKKTIIPNLRTGDLGMSPKNVNVDNIVLRNTNDMIRNHTIEKVGIQLRSYMQNMKSLSFN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ARGB_NEIG1
Sequence: MEFENIISAADKARILAEALPYIRRFSGSVAVIKYGGNAMTEPALKEGFARDVVLLKLVGIHPVIVHGGGPQINAMLEKVGKKGEFVQGMRVTDKETMDIVEMVLGGHVNKEIVSMINTYGGHAVGVSGRDDHFIKAKKLLVDTPEQNSVDIGQVGTVESIDTGLVKGLIERGCIPVVAPVGVGEKGEAFNINADLVAGKLAEELNAEKLLMMTNIAGVMDKTGNLLTKLTPKRIDGLIADGTLYGGMLPKIASAVEAAVNGVKATHIIDGRLPNALLLEIFTDAGIGSMILGRGEDA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METXA_CORJK
Sequence: MNPEFLPASGASRTVSIGDVVTEAGVTIFDAELRYFAFYDSPDGAADYAEFSAGPEPGLSPEERPIVLIEHALTGDGNAADWWADMVGPNKPIDTTRYLVLCANVLGGCQGSTGPSSPHPDGQAWGSRFPGLSIRDMVTAERQLLERVGVTKIHALIGASMGGARVLEWSLMHPEMINAALPIAVSARASAWQIGLQSSQIRFIEADPAWHGGDYYDTGEVPSHGLGQARRIAHLTYRGELEVDERFGVDPQNGENPYGPYRDPHQRFAVESYLDRQAEKLVARFDAGSYVVLTDALNRHDVGRSRGGMNAALGSCEVPTMVVGVDTDILYPLHQQEHLSRNLGDFIGMSKITSPTGHDGFLIESRQMGQALAKFLAKAEIIAEGTEGAEGTARA
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BDS1_ANESU
Sequence: AAPCFCSGKPGRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH
What is the function of this protein?
Acts as a gating modifier on both Kv and Nav ion channels, and also acts on blood pressure.  Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3. 1/KCNC1, Kv3. 2/KCNC2 and Kv3. 4/KCNC4) and slows inactivation of the voltage-gated sodium channel Nav1. 7/SCN9A (PubMed:16177043, PubMed:22442564, PubMed:9506974).  Inhibits all Kv3. 1, Kv3. 2 and Kv3. 4 by about 50% when tested at a voltage of +40 mV (45%, 48% and 56%, respectively).  May act by binding residues in voltage-sensing domains S3b and S4 of Kv3 (PubMed:16177043).  On sodium channel, tests have been done on human Nav1. 7/SCN9A (expressed in HEK293 cells) (EC(50)=3 nM) and rat SCG neurons that mostly carry Nav1. 7 channels (EC(50)=300 nM) (PubMed:22442564).  This toxin also reduces blood pressure (Ref. 1).
What are the official names of this protein?
Delta/kappa-actitoxin-Avd4a, Delta/kappa-AITX-Avd4a, Antihypertensive protein BDS-1, Blood depressing substance I, BDS-I.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: OBG_LACAC
Sequence: MPTFVDQTKIEVQAGKGGDGMVAFRHEKYVPNGGPAGGDGGRGGSIIFVADSGLRTLMDFRYRRKFKADNGENGRIKSQYGRGAKDLYLKVPVGTTVYDFNTGELIGDLVEKGQELVVAKGGRGGRGNIHFATSVNTAPEIAENGEPGEDRVLRLELKLLADVGLVGFPSVGKSTLLSVTTKAKPKIAAYQFTTLTPNLGMVILPDGRDFSMADLPGLIEGASQGVGLGIQFLRHVERTKVILHLVSMDPNNGREAIEDYHTIRQELKSYATDLSDKRELIVASQMDIPGADKKLAQFRKDLEKESNDEPVYAISSVTHAGVSKLMNDTATLVEEVEKERVEEPKVVQKTKEYKYKAPQRNEFMVEKVGEHEFVVKGEQLERLVQMTNLDHQDGIMRLARRLKRLGVDDALREKGAVNGDDVAIGKFVFEFVQ
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_SULIL
Sequence: MSNEIVDKLYKVILDRIEKRPTGSYTAEIVNKGKAYVARKVGEESVETIVASLAENKERFISEVADLIYHLLVLMALEGVTPDDIYRELERRRK
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDLI3_PIG
Sequence: MPQNVILPGPAPWGFRLSGGIDFNQPLIITRITPGSKAAAANLCPGDVILAIDGYGTESMTHADAQDRIKAAAHQLCLKIDRAETRLWSPQVTEDGKAHPFKINLESEPQDVNYFEHKHNIRPKPFIIPGRSSGCSTPSGIDGGSGRSTPSSVSTLSTICPGDLKVAAKMAPNIPLEMELPGVKIVHAQFNTPMQLYSDDNIMETLQGQVSTALGETPSMSEPTTASVPPQSDVYRMLHDNRNEPTQPRQSGSFRVLQELVNDGPDDRPAGTRSVRAPVTKIHGGAGGTQKMPLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFVEGELYCETHARARMRPPEGYDTVTLYPKA
What is the function of this protein?
May play a role in the organization of actin filament arrays within muscle cells.
What are the official names of this protein?
PDZ and LIM domain protein 3, Actinin-associated LIM protein, Alpha-actinin-2-associated LIM protein.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines.
Protein: WIPI2_MOUSE
Sequence: MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSASIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLEAVREKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETTSEIVDSASHDCPLATQTYGTAAAKGAYVPSSPTRLGKGQDANLEAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
What is the function of this protein?
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.  Involved in an early step of the formation of preautophagosomal structures.  Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:23051912, PubMed:23291478, PubMed:24954904).  Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (By similarity).  Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane.
What are the official names of this protein?
WD repeat domain phosphoinositide-interacting protein 2, WIPI-2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P.
Protein: MRAZ_SHEHH
Sequence: MFSGASAINLDTKGRIAIPKRYREPLHACHNSQLVITVDIQSSCLLLYPIQEWEKVAAKLALLSDTQPTERAIKRMLLGYAHECELDGNGRMLLPTPLRQYANLDKRAMLVGQLNKFELWDEAAWQQQIEQSRLAILNEDLAANERLADFSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ABCBA_MOUSE
Sequence: MRAPSARALLLIPRRGPAVRAWAPAVSSRIWLASEWTPLVRAWTSLIHKPGSGLRFPAPLSGLPGGVGQWATSSGARRCWVLAGPRAAHPLFARLQGAAATGVRDLGNDSQRRPAATGRSEVWKLLGLVRPERGRLSAAVGFLAVSSVITMSAPFFLGRIIDVIYTNPSEGYGDSLTRLCAVLTCVFLCGAAANGIRVYLMQSSGQSIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSLATFVLSVVPPISVLAVIYGRYLRKLSKATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTGRVDQLLQLAQKEALARAGFFGAAGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGLSIGGLSSFYSELMKGLGAGGRLWELLERQPRLPFNEGMVLDEKTFQGALEFRNVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEHGTHEELLLKPNGLYRKLMNKQSFLSYNGAEQFLEPARA
What is the function of this protein?
Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner (PubMed:26053025).  May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria (PubMed:28808058, PubMed:26053025).  Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX).  In turn participates in hemoglobin synthesis and also protects against oxidative stress (PubMed:22240895, PubMed:28808058, PubMed:24421385).  In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (By similarity).
What are the official names of this protein?
ATP-binding cassette sub-family B member 10, mitochondrial, ABC-mitochondrial erythroid protein, ABC-me protein, ATP-binding cassette transporter 10, ABC transporter 10 protein.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL2_PEDPA
Sequence: MGIKKFKPTTNARRGMTQLDYSEITKKSPEKSLLESQSHTAGRNNYGRMTVRHRGGGNKRQYRIIDFKRIKDDVPATVKAIEYDPNRTANIALLVYADGVKSYIIAPKGLKVGDKVQSGSEADIKVGNALPLKDIPVGTVIHNIELKPGKGGQLVRSAGASAQLLGKEGKYVLIRLASSEVRMVLATNRATIGAVGNEEHELVNVGKAGRTRYAGQRPHVRGSVMNPNDHPHGGGEGKAPIGRPSPLSPWGKKTIGKKTRNKHNKSNKFIVRGRKRGRLGNI
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PG021_VACC0
Sequence: MEFDPAKINTSSIDHVTILQYIDEPNDIRLTVCIIRNINNITYYINITKINTHLANQFRAWKKRIAGRDYITNLSRDTGIQQSKLTETIRNCQKNRNIYGLYIHYNLVINVVIDWITDVIVQSILRGLVNWYIANNTYTPNNTTTISELDIIKILDKYEDVYRVSKEKECGICYEVVYSKRLENDRYFGLLDSCNHIFCITCINIWHKTRRETGASDNCPICRTRFRNITMSKFYKLVN
What is the function of this protein?
RING-finger E3 ubiquitin ligase which catalyzes the formation of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.  Plays an important role in virulence by acting as an anti-apoptotic factor.
What are the official names of this protein?
host range factor p28, E3 ubiquitin-protein ligase p28.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG021 family.
Protein: ARLR_STAAB
Sequence: MTQILIVEDEQNLARFLELELTHENYNVDTEYDGQDGLDKALSHYYDLIILDLMLPSINGLEICRKIRQQQSTPIIIITAKSDTYDKVAGLDYGADDYIVKPFDIEELLARIRAILRRQPQKDIIDVNGITIDKNAFKVTVNGAEIELTKTEYDLLYLLAENKNHVMQREQILNHVWGYNSEVETNVVDVYIRYLRNKLKPYDRDKMIETVRGVGYVIR
What is the function of this protein?
Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence.
What are the official names of this protein?
Response regulator ArlR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_PROM5
Sequence: MTAKTEEILESLKSLSLLEASELVKQIEEAFGVSAAASAGVVMAAPGAAGGDGDGGAAEEKTEFDVILESFDAAAKIKVLKVVRNATGLGLGDAKALVESAPKTVKEGIAKADAETLKKEIEEAGGKVTLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: CLC10_HUMAN
Sequence: MTRTYENFQYLENKVKVQGFKNGPLPLQSLLQRLCSGPCHLLLSLGLGLLLLVIICVVGFQNSKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAGVSELQEHTTQKAHLGHCPHCPSVCVPVHSEMLLRVQQLVQDLKKLTCQVATLNNNASTEGTCCPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAYTWMGLSDPEGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCAHFHPDGRWNDDVCQRPYHWVCEAGLGQTSQESH
What is the function of this protein?
Probable role in regulating adaptive and innate immune responses.  Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine.  These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
What are the official names of this protein?
C-type lectin domain family 10 member A, C-type lectin superfamily member 14, Macrophage lectin 2.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: ANGE2_BOVIN
Sequence: MEAWRCVRRGYGRCVVGRGRYPMLPHHQKSLGRDWTTPWENLQKCCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWRPPGLFESRAPFQYWNWRPDSLSQTSLFHLSSYIMNSEGDEPSSKRRKHQGTIQRHWEYICNHNKENTKILGDENVDPICEDSENKFEFSVMSYNILSQDLLEDNSHLYKHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGTEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFYRRDVPLLDRDNVGLVLLLQPKIPSATSPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGRFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKPDGDLTQPELDKTEVLVTAEKLSSNLQHHFSLSSVYSHYLPDTGIPEVTTCHSRSAVTVDYIFYSAEKEGVAEQPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL
What are the official names of this protein?
Protein angel homolog 2.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
Protein: SSUD_RALSO
Sequence: MQVFWFLPTHGDSRYLGTAEGARQVDQAYLQQVAVAADTLGYEGVLIPTGRSCEDPWIVAASLIPATRRLRFLVAVRPGLVAPTLAARMAATFDRLSQGRLLVNLVTGGDPGELAGDGLFLDHAQRYEASAEFIRIWRETLAASHEGAALDYTGRHLSVKGARVLFPPVQRPHPPVYFGGSSEAAHALAAEQVDTYLTWGEPPAAVAEKIADVRRRAARHGRTVRFGIRLHVIVRETEDAAWQAADTLISKLDDDTVARAQAAFRKMDSAGQQRMAALHANGIRRSRAELEISPNLWAGVGLVRGGAGTALVGDPHTVAARMREYADLGIDTFVLSGYPHLEEAYRFAELVFPLLPRAVRDTLPGSVLNGPFGEVIATGIVPRVAAS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: Y1707_STAAC
Sequence: MKIKEMVTSEMPRERLLSHGAKSLSNTELLAILINTGRKGFSSIDISNELLKSASNLNELKKSSINDLIKVKGIGLQKAITLKAAFELGERMGRRAENNRIKITQPSDVADYMIPTMKDLTQEHFVILLLNSKNVVIKETCVFKGTLNSSIVHPREIFSIAVRENANAIIAVHNHPSGDVTPSQEDIITTMRLKECGLILGIDLLDHIIIGDNRFTSLVEAGYFDEND
What are the official names of this protein?
UPF0758 protein SACOL1707.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: TF2H2_BOVIN
Sequence: MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKSLKAAKIRVSIIGLSAEVRVCTALARETGGTYHVILDESHYKELLTHHVSPPPASSNSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDSNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEHNGERFCYACQGELKDQHVYVCSVCQNVFCVDCDVFVHDSLHCCPGCIHKIPVPSGI
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.  The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
What are the official names of this protein?
General transcription factor IIH subunit 2, General transcription factor IIH polypeptide 2.
What is the protein family that this protein belongs to?
Belongs to the GTF2H2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL4_RIPO1
Sequence: MVNCIIKNWQGEEVGQATLELKVAKEENAAHIVHRALVRQQTNARQGTASTKTRAEVRGGGRKPWRQKGTGRARAGSIRSPLWRGGGVTFGPKPKDFNVKMNRKERRLALRTALDSRIEDLIVVENFAEQLTQPKTKELVSALTRWGIDGNQKVVLIVSEITDNIQLSARNVPYIKLLKADGLNVYDLLVADKIVATAEALSKVQEVYSDS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: COX1_ORTCH
Sequence: MFVNRWLFSTNHKDIGTLYMIFGAWAGMVGTGLSILIRAELGQPGSLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAITQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATMNGGNIKWSPAMLWALGFIFLFTIGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFTGYTLNDTWAKIHFTIMFVGVNLTFFPQHFLGLAGMPRRYSDYPDAYTTWNTISSMGSFISLTAVILMVFMIWEALASKRTVKSISLTSTNLEWIHGCPPPFHTFEEPAFIKSSH
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPOB_RUEPO
Sequence: MAQTFLGQKRLRKYYGKIREVLEMPNLIEVQKSSYDLFLNSGDAPQPLDGEGIMGVFQSVFPIKDFNETSVLEFVKYELEKPKYDVEECMQRDMTYSAPLKVTLRLIVFDVDEDTGAKSVKDIKEQDVFMGDMPLMTPNGTFIVNGTERVIVSQMHRSPGVFFDHDKGKTHSSGKLLFACRIIPYRGSWLDFEFDAKDIVFARIDRRRKLPVTTLLYALGLDQEGIMDAYFKTVSYRLEKKRGWVTPFFPERVRGTRPTYDLIDAASGEVIAEAGKKVTPRAVKKLIEEGSVTDLLVPFDHIVGKFAAKDIINEETGAIYVEAGDELTLEYDKDGDLIGGTVKELIDNGVTNIPVLDIDNINVGPYIRNTMAQDKNMNRETALMDIYRVMRPGEPPTVEAASALFDTLFFDSERYDLSAVGRVKMNMRLDLDAADTQRTLRREDIIACIKALVELRDGKGDIDDIDHLGNRRVRSVGELMENQYRVGLLRMERAIKERMSSVEIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRMCPIETPEGPNIGLINSLATFARVNKYGFIETPYRVVKGGQVTDEVHYMSATEEMRHTVAQANATLDENGKFVNELVNTRQAGDYTLAPMESVDLIDVSPKQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLRAEAPLVGTGIEEKVAIDSGAAIQAKRAGIIDQIDAQRIVIRATEDLELGDAGVDIYRMRKFQRSNQNTCINQRPLVKVGQQVSKGEVIADGPSTDMGELALGKNVVVAFMPWNGYNYEDSILISERIARDDVFTSIHIEEFEVAARDTKLGPEEITRDIPNVGEEALRNLDEAGIVYIGAEVQPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSLRVKPGDYGTVVEVRVFNRHGVDKDERALQIEREEVERLARDRDDELAILDRNIYARLKSLILGKTAVKGPKGIKPGSEITEELLETLTRGQWWMLALEGEQDAQIVEALNEQYELQKRALDARFEDKVEKVRRGDDLPPGVMKMVKVFIAVKRKLQPGDKMAGRHGNKGVISKVVPMEDMPFLADGTPVDFCLNPLGVPSRMNVGQILETHMGWAARGLGLNVDEALQEYRRSGDLTPVRDAMKHAYGEDVYAEGISGMDEDTLVEAAGNVTRGVPIATPVFDGAKEADVNDALTRAGFDTSGQSVLFDGRTGEQFARPVTVGIKYLLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYESIVKGEDNFEAGIPESFNVLVKEVRGLGLNMELLDAEVEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: FLGG_BORBU
Sequence: MMRALWTAASGMTAQQYNVDTIANNLSNVNTTGFKKIRAEFEDLIYQTHNRAGTPATENTLRPLGNQVGHGTKIAATQRIFEQGKMQSTNLLTDVAIEGDGFYKILLPDGTYAYTRDGSFKIDSNRELVTSQGYKVLPNILFPEEYIQNSITISEEGIVSVKIDTSNEPIELGQIEISRFINPAGLSAIGSNLFKETAGSGQEIAGIPGSEGMGRLRQGILEMSNVSIAEEMVTMIVAQRAYEINSKAIQTSDNMLGIANNLKRQ
What are the official names of this protein?
Flagellar basal-body rod protein FlgG, Distal rod protein.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: BGALA_EMENI
Sequence: MRLLPVWTAALLAAQAAGVALTHKLNGFTITEHPDAEKRELLQKYVTWDDKSLFINGERIMIFGAEIHPWRLPVPSLWRDILQKVKALGFNCVSFYVDWALLEGKPGEYRAEGSFAWEPFFDAASDLGIYLIARPGPYINAEASGGGFPGWLQRLNGTIRSSDQSYLDATENYVSHIGGLIAKYQITNGGPVILYQPDNEYSGGCCGQEFPNPDYFQYVIDQARRAGIVVPTISNDAWPGGHNAPGTGKGEVDIYGHDNYPLGFDCANPDVWPEGNLPTDYRDLHLEISPSTPYALVEYQVGAFDPWGGPGFEQCAALTGYEFERVFHKNTFSFGVGILSLYMTFGGTNWGNLGHPGGYTSYDYGSPIKETREITREKYSELKLLGNFIKSSPGYLLATPGKLTNTTYTNTADLTVTPLLGNGTGSFFVLRHSDYSSQASTPYKLRLPTSAGQLTIPQLGGSLVLNGRDSKVHLVDYDVAGTKILYSTAEVFTWKKFHDGKVLVLYGGPGEHHELAVSSKAKVKVVEGLGSGISSKQIRGAVVVAWDVEPARRIVQIGDLKIFLLDRNSAYNYWVPQLGTETSIPYATEKAVAASVIVKAGYLVRTAYVKGRDLHLTADFNATTPVEVIGAPKTAENLFINGKKAHHTVDKNGIWSTEVGYSPPKIVLPVLEDLKWKSIDTLPEIQPSYDDSPWPDANLPTKNTIYPLRTPTSLYASDYGFHTGYLLFRGHFTANGRESNFSIQTQGGQAFGSSVWLSGTYLGSWTGDNDYQDYNATYTLPSLKAGKEYVFTVVVDNMGLNENWIVGQDEMKKPRGILNYELSGHEASDITWKLTGNFGGEDYVDKVRGPLNEGGLYAERHGYHQPYPPTKSKDWKSSTPLTGLSKPGISFYTASFDLDIKSGWDVPIYFEFGNSTTPAPAYRVQLYVNGWQYGKYVNNIGPQTRFPVPEGILNYKGTNWVAVTLWALEGSGAKLDSFKLVHGIPVRTALDVEGVELPRYQSRKGVY
What is the function of this protein?
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
What are the official names of this protein?
Probable beta-galactosidase A, Lactase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
What are the subcellular locations of this protein?
Secreted.