PharMolix/UniProtQA huggingface dataset:
Protein: CAPSD_POLVP
Sequence: MALVKRNNNMALIATEAGKLAAVKAGQVMLSPAGRELIWNGVNWVRRKLGRSKKSDVILHPGVLPGAIAAPVANTRIIRASKPKFTRSKGSVTIAHRELLGQFNNSSGLVVNGGVSGNLYRINPSNPVVFPWLQGIAASFDQYKFDRVQLQYVPMCATTETGRVAIYFDKDQQDVEPADRVELANMGHWTESAPWCESTLNVPVDNVKRFMNDNTTTDRKLVDLGQIGLATYGGGSTNPVGDLFIHYTITLFEPQPLASLVETEQSGAGAAPFGTNLVTVSSNATTTIITFRGPGVYLLALSQRAASFTTLVTAGGAVVNSHTTLFSGPAYQSIANITATIPGGSITYNGTLFGNYTLQVTRAKISNNATLI
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins.
What are the official names of this protein?
Capsid protein, p40.
What is the protein family that this protein belongs to?
Belongs to the icosahedral plant coat protein family.
What are the subcellular locations of this protein?
Virion.
Protein: ASSY_MYCTA
Sequence: MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEHMDVIRQRALDCGAVEAVVVDARDEFAEGYCLPTVLNNALYMDRYPLVSAISRPLIVKHLVAAAREHGGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEENAIPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDIYAYTEDPTINWGVPDEVIVGFERGVPVSVDGKPVSMLAAIEELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFKRQTDQRWAELVYDGLWYSPLKAALEAFVAKTQEHVSGEVRLVLHGGHIAVNGRRSAESLYDFNLATYDEGDSFDQSAARGFVYVHGLSSKLAARRDLR
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLBT_BRUSI
Sequence: MAANSKTAIRLSLRAGERIFINGAVLRADRKVSLELLNDATFLLENHVLQPEDTTTPLRQLYFAAQMMLIEPAMREQAGATFAQMLKGMFATFKDAEILNALKLVDELVHNGRVFEALKTIRAQYPREAELMGAQPVVWPVTKSGKSAGANP
What is the function of this protein?
Has a post-transcriptional repressor function in flagellum biogenesis.  Associates with the 5'-UTR of fljK mRNA and promotes its degradation.
What are the official names of this protein?
Probable flagellum biosynthesis repressor protein FlbT.
What is the protein family that this protein belongs to?
Belongs to the FlbT family.
Protein: YHFG_ECOLI
Sequence: MKKLTDKQKSRLWELQRNRNFQASRRLEGVEMPLVTLTAAEALARLEELRSHYER
What are the official names of this protein?
Uncharacterized protein YhfG.
Protein: SYL_PEDPA
Sequence: MAYNHKDIEQKWQQFWSDNETFKTVEDADKPKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRMKRMQGYKVLHPMGWDAFGLPAEQYAMKTGNNPRDFTAKNIQNFKRQIQSLGFSYDWSREVNTTDPAYYKWTQWIFEQLYKKGLAYEKETLVNWAPDLMGGTVVANEEVVDGKTERGGFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSVGASVFFNVEDSEKQIEVFTTRPDTLFGATYLVISPEHDLVDQITTPESKAAVEEYKKAVATKSDLERTDLNKDKTGVFTGAYAVNPVNGKKIPVWISDYVLASYGTGAVMAVPAHDGRDYEFAKKFKIDMVPVYEGGNLEDGVLDSEGGLINSGFLDGMDKQTAIDTMISWLEEHGVGHKKVNYRLRDWVFSRQRYWGEPIPVIHWEDGETTLIPEDELPLRLPAATDIRPSGTGESPLANLDDWVNVVDENGRKGRRETNTMPQWAGSSWYFLRYVDPKNDQKIADEDLLKEWLPVDLYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTLRLYEMFMGPLTESVAWSEDGLNGSRKWIDRVWRLMIDDENQLRDHIVTENDGSLDMIYNQTVKKVTDDYENMRFNTAISQMMVFVNEAYKADKLPAVYMEGLVKMLAPIIPHVAEELWSLLGHEGGISYAEWPTYDESKLVEATVQVILQVNGKVRSKITVDKDIAKEELEKLALADAKIQQWTADKTVRKVIVIPNKIVNIVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GT15_ARATH
Sequence: MKNNNSSSVSIENHPWKKKPTTLLLFLSLLSISLLLLRLSQDKIILITTTKTTATTGTDHQRSHKSSEDDTCLGRYIYIHNLPSRFNLEIIKDCKSITRPKDKISMCKYLDNSGFGPLIGGKSSDYSPSWYATNQFMLEVIFHEKMKSYECLTRNSSLASAIYVPYYAGLDFRRHLRRRNVAARDAAGKELVKWLKKQPQWKDMSGKNHFLVTGRISRDFRRNSGSRSAWGTNFMLLSESLNLTFLSIERSLTSHNEFAIPYPTYFHPTSTPEILQWQEKIRLTNRTVLFSFAGAQRPSRNQNGVVRTEVIKQCKSSSKTCRFLDCDVNANSCDDPISLMKLFESSTFCLQPPGDSLTRKSVFDSILAGCIPVFFNQGSAYKQYLWHIPKNSSKYSVYITVKELRTGGKNKIEEILRGIPNERVVGMRENVIRLIPKIVYAKPNRNKPDGEILEDSFDVAVKGVLERIEGIRRNEFKTD
What is the function of this protein?
Functions in xyloglucan synthesis by adding side chains to the xylosylated glucan backbone.  Involved in the galactosylation of hemicellulose xyloglucan.
What are the official names of this protein?
Probable xyloglucan galactosyltransferase GT15, Glycosyltransferase 15, AtGT15.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 47 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: YQGF_ROSS1
Sequence: MSSEPGRVMALDVGERRIGVALSDPTRMLASPLTTIRAVPRSTALKRILTLIRDYQVTALVVGLPLTMNGDIGPQATLVQQFVDELRPLIDIPIFFVDERLTTVAAERMMIDLKIKPEQRRARIDEVAASIILQDFLDSQR
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_SHESA
Sequence: MAELKNDRYLRALLKQPVDMTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVTLQPLRRYELDAAILFSDILTVPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLAVPDPEDDLGYVMKAVSTIRRELNGQVPLIGFSGSPWTLATYMVEGGSSKTFEKIKKMAYAEPAALHMLLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHTAYREFSLRYMQKIVDGLTRFADGRQVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVAQILAGYGEGTGHVFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_PSEA7
Sequence: MARVKRGVIARRRHKKILKLAKGYYGARSRVFRVAKQAVIKAGQYAYRDRRQRKRQFRALWIARINAGARQNGLSYSRLIAGLKKAAIEIDRKVLADLAVNEKAAFTAIVEKAKASLA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: CARP1_ARTBC
Sequence: MRGILILVALGAATIPQASAAPNDRQQSMIDLPLKLYQNGFNTDLVTIGTPAQATRLFVDWTWIGAYTVSTKCNHTNNAYGCLAPGQKLFNETQSTSLVNQTNLYPTRTWNPNHFFMDKDLTAVFASDIYRVGDRESRLTLQLSQLNWKASFPYPFSGIFGMSPVFKSDNMSIQAPFHQMVQQKKFHSGLTSFIYCYSDEPGYKSPSKERCNGNDGIQTLGGYHHRDIGWRGIEWINTIVFPIVNDIDFIYNPAFYNYWSIPVTKHFIGNEEQALNTTTGSAVVFDHASYGRGAAMSVASYRRLVSITNAQPVNLTMATLPNNGKQKFYSVDCDRVDSFPAVKYQFGKWRRVWSIEARHYISKAKTMDGKDVCVLNVRVIGQGENFVIGNLGENFAKDKVILFDFEKNRVGLADFRD
What is the function of this protein?
Probable secreted aspartic protease that supplies the fungus with nutrient amino acids (By similarity).  May be able to degrade the selected host's proteins involved in the immune defense (By similarity).
What are the official names of this protein?
Probable secreted aspartic protease ARB_07536.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
Protein: HBAD_CAIMO
Sequence: MLTAEDKKLIVQVWEKVAGHQEEFGSEALQRMFLAYPQTKTYFPHFDLHPGSEQVRGHGKKVAAALGNAVKSLDNLSQALSELSNLHAYNLRVDPVNFKLLAQCFQVVLAAHLGKDYSPEMHAAFDKFLSAVAAVLAEKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-D, Alpha-D-globin, Hemoglobin alpha-D chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CACT_DROYA
Sequence: MPSPTKAAEAATKATATSDCSCSAASVEERGPVNAANPSSTXATSGKIGGKTQDQTAAINKPKEFAVPNETSDSGFISGPQSSQICSEEIVPDSEEQDKNQQQSAPQKEQPVVLDSGIIDEEEEHQDTTTATADSMRLKHSADTGIPQWTVESHLVNRGEQLNNLGQSSSTQITGRSKFQSSTASTANANPSGXGATSSAPPSSINIXNAWEQFYQQNDDGDTPXHLACISGSVEVVAALIRMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMRILLLAGAEVRDRHGNTALHLSCIAGEKQCVRALTEEFGATEIHEAHRQYGHRSNDKAVSSLSFARLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNEDLANFLLDECEKLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAETVTPPDSDYDSSDIEDLDDTKMYDRFGDPRYFVSYNGGNPMTVA
What is the function of this protein?
Involved in the formation of the dorsoventral pattern.  It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo.
What are the official names of this protein?
NF-kappa-B inhibitor cactus.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUMO4_ARATH
Sequence: MSTTSRVGSNEVKMEGQKRKVVSDPTHVTLKVKGQDEEDFRVFWVRRNAKLLKMMELYTKMRGIEWNTFRFLFDGSRIREYHTPDELERKDGDEIDAMLCQQSGFGPSSIKFRV
What is the function of this protein?
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer.  Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (By similarity).
What are the official names of this protein?
Putative small ubiquitin-related modifier 4, AtSUMO4.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: AFAD_HUMAN
Sequence: MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELSPGRRNHFAYYNYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEEDCSLAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENELNTK
What is the function of this protein?
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity).  Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295).  May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity).  Essential for the organization of adherens junctions (PubMed:30463011).
What are the official names of this protein?
Afadin, ALL1-fused gene from chromosome 6 protein, Protein AF-6, Afadin adherens junction formation factor.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Note=Not found at cell-matrix AJs.
Protein: RL13_AZOC5
Sequence: MKTYSAKPADIEKKWVVIDATGLVVGRLATVIAMRLRGKHRATFTPHVDTGDNVVVINAEKVVLTGRKRDQKVYYHHTGFPGGIKERTAKFILDGRFPERVIEKAVERMLARGPLGRKVLGNLRVYKGPTHPHEAQQPTVLDVAALNSKNVRI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: WNT2_PAPAN
Sequence: MNAPLGGIWLWLPLLLTWLTPEVNSSWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGEVKSCSCDPKKMGSAKDSKGIFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCGCKFHWCCAVRCQDCLEALDVHTCKAPKNADWTTPT
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity).  Functions as upstream regulator of FGF10 expression.  Plays an important role in embryonic lung development.  May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
What are the official names of this protein?
Protein Wnt-2.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: Y1072_METJA
Sequence: MIYFGGIMAIAYAKLYEIIAKYIKDEKRAEELYNAVVEVIKEEKIIVKHELKDELKNELATKEDIMLAEERILRYVDNRFNQLDKKMTVGFVILILLYILTNPNAIELIKLLFGVK
What are the official names of this protein?
Uncharacterized protein MJ1072.
What is the protein family that this protein belongs to?
Belongs to the M.jannaschii MJ0023/MJ0349/MJ1072/MJ1074/MJ1107/MJECL16 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TIM44_HUMAN
Sequence: MAAAALRSGWCRCPRRCLGSGIQFLSSHNLPHGSTYQMRRPGGELPLSKSYSSGNRKGFLSGLLDNVKQELAKNKEMKESIKKFRDEARRLEESDVLQEARRKYKTIESETVRTSEVLRKKLGELTGTVKESLHEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGEKLGRTAAFRALSQGVESVKKEIDDSVLGQTGPYRRPQRLRKRTEFAGDKFKEEKVFEPNEEALGVVLHKDSKWYQQWKDFKENNVVFNRFFEMKMKYDESDNAFIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLKQCENDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDNVDLAMGKMMEQGPVLIITFQAQLVMVVRNPKGEVVEGDPDKVLRMLYVWALCRDQDELNPYAAWRLLDISASSTEQIL
What is the function of this protein?
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity).  Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM44.
What is the protein family that this protein belongs to?
Belongs to the Tim44 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion matrix.
Protein: FEN1_YEAST
Sequence: MGIKGLNAIISEHVPSAIRKSDIKSFFGRKVAIDASMSLYQFLIAVRQQDGGQLTNEAGETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPDLKSHELTKRSSRRVETEKKLAEATTELEKMKQERRLVKVSKEHNEEAQKLLGLMGIPYIIAPTEAEAQCAELAKKGKVYAAASEDMDTLCYRTPFLLRHLTFSEAKKEPIHEIDTELVLRGLDLTIEQFVDLCIMLGCDYCESIRGVGPVTALKLIKTHGSIEKIVEFIESGESNNTKWKIPEDWPYKQARMLFLDPEVIDGNEINLKWSPPKEKELIEYLCDDKKFSEERVKSGISRLKKGLKSGIQGRLDGFFQVVPKTKEQLAAAAKRAQENKKLNKNKNKVTKGRR
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1, RAD2 homolog nuclease 1, RTH1 nuclease, Structure-specific endonuclease RAD27.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: MAN12_CAEEL
Sequence: MKTVRFNKQALAILAACFIFLLCVVCYFSASSESHNAVVVGERARGHIAVRDVENRHLAEEKHAVIHAKTVGKIERVVSQEKVEILRPARVESKPPGEKTSTEPEETGVGKAPIQTSEGLEKLIGKIHYENKDEENDLRRQKVKEMMIHAWEGYKNYSWGANELRPMSKKPNSQNIFGGSQMPATIVDAADTLFIMDLKDKYKEARDYIENNFSMAKSTSTLSVFETTIRFLGGLLSLYALTQESFYIEKAREVGEALLPAFNTPSGIPKSNLDVASKHASNYGWANGGQSILSEIGSLHLEFLYLSRISNAPIFEKKVKKVRDALEKAEKPNGLYSNYINPDTGKFTGSHMSLGALGDSFYEYLIKSYVQSNYTDTQAKNMYWDVSDAIQKHMIKVSKQSNLTYTVELNNGQAQHKMGHLACFVPGMFALQAINEDTEEEKLRIMTLAEELAKTCHESYIRSETHIGPEMFYFNERDEATSKHSENGYIQRPEVIEGWFYLWRLTGKTMYRDWVWDAVQAIEKYCRVDSGFTGLQNVYNPKAGREDVMQSFFLAEFLKYAYLTFADESLISLDKWVFNTEAHPVPVLTN
What is the function of this protein?
Involved in the maturation of Asn-linked oligosaccharides.  Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) (By similarity).
What are the official names of this protein?
Mannosyl-oligosaccharide 1,2-alpha-mannosidase C52E4.5, Processing alpha-1,2-mannosidase C52E4.5, Alpha-1,2-mannosidase C52E4.5.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: GCSP_MYCA1
Sequence: MPDHTTFAARHIGPDPQAVAAMLDVIGVGSLDELAAKAVPAGIRDRLSADGIAPGLDRLPPPASETEALAELRGLAEANTVAVSMIGQGYYDTLTPPVLLRNILENPAWYTAYTPYQPEISQGRLEALLNFQTMVADLTGLEIANASMLDEGTAAAEAMTLMHRASRGKSNRLAVDVDVFAQTAAIVATRARPLGIEIVTADLRDGLPDGDFFGVIAQLPGASGAITDWAALVAQAHERGALVALGADLLALTLITPPGEIGADVAFGTTQRFGVPMGFGGPHAGYLAVHANHARQLPGRLVGVSLDADGSPAYRLALQTREQHIRRDKATSNICTAQVLLAVMAAMYASYHGAEGLTAIARRVHGHAEAIAAALGTAVVHDRYFDTVLARVPGRAHEVIAAAKARGINLWRVDDDHVSVACDEATTDEHVAAVLEAFGVAPAEPVASEIATRTSEFLTHPAFTQYRTETAMMRYLRTLADKDIALDRSMIPLGSCTMKLNAAAEMEPITWPEFARQHPFAPASDTPGLRRLIGDLENWLVAITGYDAVSLQPNAGSQGEYAGLLAIHDYHASRGEPHRDICLIPSSAHGTNAASAALAGMRVVVVGCHDNGDVDLDDLRAKVTDHRDRLSTLMITYPSTHGVYEHDIAEICAAVHDAGGQVYVDGANLNALVGLARPGKFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVRSHLAPFLPGHPHAPELPQGHPVSSAPYGSASILPISWAYIRMMGADGLRAASLTAITSANYIARRLDEYFPVLYTGENGMVAHECILDLRPITKATGVTVDDVAKRLADYGFHAPTMSFPVAGTLMVEPTESETLTEVDAFCDAMIAIRGEIDRVGAGEWPVEDNPLRGAPHTAECLVTTDWDHPYSREQAAYPLGKDFRPKVWPPVRRIDGAYGDRNLVCSCPPVEAFA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: DEOD_LACLM
Sequence: MPTPHIEAQKGEIADKILLPGDPLRAKFIAENFLEDAVQFNQVRGMLGFTGTYKGHRVSVMGTGMGIPSISIYANELITEYGVKRLIRVGTAGSVNEDVHIRDLVIGQAAATTSAIVRHDFPDFDFPQIADFDLLDKAYHIAKDLGITTHVGNILSSDLFYGGPDAVKVGKLGVKAVEMEAAGLYYLGAKYKVQTLGIMTISDHILTGESTTSEERQLTFTDMMKVGLETLIAE
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: RECR_STAEQ
Sequence: MHYPEPISKLIDSFMKLPGIGPKTAQRLAFHTLDMKEDDVVKFAKALVDVKRELTYCSVCGHITENDPCYICEDKQRDRSVICVVEDDKDVIAMEKMREYKGLYHVLHGSISPMDGIGPEDINIPALVERLKNDEVKELILAMNPNLEGESTAMYISRLVKPIGIKVTRLAQGLSVGGDLEYADEVTLSKAIAGRTEM
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: Y780_HAEIE
Sequence: MFGKGGLGGLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKIAINGAHNCRRIDIDPSLMEDDKEMLEDLIAAAFNDAVRRAEELQKEKMASVTAGMPLPPGMKFPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein CGSHiEE_00780.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PRDX6_MESAU
Sequence: DFTPVCTTELGRLAPEFAKRVVFIFGPDKKLKLSILYPATTGRNFDEILR
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity).  Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity).  Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity).  These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity).  Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity).  Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity).  Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity).
What are the official names of this protein?
Peroxiredoxin-6, 1-Cys peroxiredoxin, 1-Cys PRX, Acidic calcium-independent phospholipase A2, aiPLA2, Antioxidant protein 2, Glutathione-dependent peroxiredoxin, Lysophosphatidylcholine acyltransferase 5, LPC acyltransferase 5, LPCAT-5, Lyso-PC acyltransferase 5, Non-selenium glutathione peroxidase, NSGPx.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome. Note=Also found in lung secretory organelles (lamellar bodies).
Protein: Y2087_MYCTU
Sequence: MLAGLRPSIGIVGDALDNALCETTTGPHRTECSHGSPFRSGPIRTLADLEDIASAWVEHTCHTQQGVRIPGRLQPA
What are the official names of this protein?
Uncharacterized protein Rv2087.
Protein: PYRI_SULIA
Sequence: MISSSKRDELIVSKIRKGTVIDHIPAGRALAVLRILGIRGSEGYRVALVMNVESKKIGRKDIVKIEDRVIDEKEASLITLIAPSATINIIRDYVVTEKRHLEVPKQIRGLIKCPNPQCITNNDVEAESRFTTISIKPLKLKCEYCEIYITEEDVIRQIL
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.