PharMolix/UniProtQA huggingface dataset:
Protein: MERL_PAPAN
Sequence: MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFSLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL
What is the function of this protein?
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis.  Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.  May act as a membrane stabilizing protein.  May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity.  Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity).
What are the official names of this protein?
Merlin, Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomin.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cytoplasm, cytoskeleton. Nucleus. Note=Colocalizes with MPP1 in non-myelin-forming Schwann cells. Binds with DCAF1 in the nucleus. The intramolecular association of the FERM domain with the C-terminal tail promotes nuclear accumulation. The unphosphorylated form accumulates predominantly in the nucleus while the phosphorylated form is largely confined to the non-nuclear fractions (By similarity).
Protein: RS5_PARXL
Sequence: MAKMQAKVQADERDDGLREKMISVNRVTKVVKGGRILGFAALTVVGDGDGRIGMGKGKAKEVPVAVQKAMEQARRNMFKVPLKNGTLQHEVHGKHGASAVLLAPAKDGTGVIAGGPMRAVFDVMGVQNVVAKSHGSTNPYNLVRATLDGLRKQSTPGDIAAKRGKSVEDILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: SYP_MOOTA
Sequence: MRASELLAPTLRETPAEAEIVSHQLLLRGGFIRKAAAGIYTYLPLGRRVLAKIEQIIREEMDRAGGQEVVLPIIQPAELWQESGRWEVYGEEMFRLQDRHRRQFCLGPTHEEIITALVRSEVTSYKQLPLLLYQIQNKYRDERRPRFGLLRGREFIMKDLYSFDLDQEGLNQSYRKMYQAYSNVFRRCGLDFRPVQADSGAIGGNYSHEFMALATAGEALLVYCRECDYAANVEIAVAKALPMIATENPAPLKEVATPGQKTVAEICTFLEVTPDRLIKTLFYEADGQLIAALVRGDRELNEVKLQNHLGCRHLLLADPERVRKATGAPVGFVGPVGLQGIPLYADLEIPYLVNGVAGANREGYHLVNVNPGRDFNPTAVVDIRQVEAGEPCPQCGAPLAQARGIEVGQVFQLGTKYSGALGANYTDARGQEHPIVMGCYGIGVSRTMAAIVEQCHDDQGIIWPLSVAPYQVVIIPASLKDDGQRQVAEGLYRELAAAGVEVVYDDRDERAGLKFVEADLIGYPLRITVGKRTITSGTVDVKWRSRKEETPLPLEGLSAQIQALLAREMEKYR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_BLOFL
Sequence: MFTKILGTGSYLPKYIRSNIILEKMVDTSNAWIIARTGIKERRISNSSETVAKMGYFASKKALDMSCIEANEIGIIIVATTSSSHAFPSSACQIQRDLKISDTIAFDLSAACSGFVYALDVANQYIKNGVVKYALIVGSDILSHFLNPNDRSTLILFGDGAGAVILGRSKSPGIISTHLHANGYYGDLLTLPHYNTQNPEKLSVYLTMSGNKVFKMAIATLTGIINETLHANNLQQDELDWLVPHQANLRIISKAAKRLNIDMEKIIITLHKHGNTSAASIPLALDEAVRDGRIKSNQLLLLEAFGAGLTWGSVLLRF
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YB21A_YEAST
Sequence: MESQQLHQNPHSLHGSAYASVTSKEVSSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQDQHSEVPQAKTKVRNNVLPPHTLTSEENFYTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYHRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLRPATERI
What is the function of this protein?
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.  The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules.  CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
What are the official names of this protein?
Transposon Ty2-B Gag polyprotein, TY2A, TYA, Transposon Ty2 protein A, A-438 protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO4_VIBVU
Sequence: MSTQMRKIIHIDMDCFYAAVEMRDNPNFRSRPLAVGGHEKQRGVISTCNYEARKFGVRSAMPTAQALKLCPSLLVVPGRMQVYKEVSTHIRSIFSRYTHLIEPLSLDEAYLDVTDSTQCHGSATLIAEAIRRDIWNELQLTASAGVAPIKFLAKVASDMNKPNGQFVIPPEQVQSVIDTLPLQKIPGVGKVSLEKLNQAGLYVCQDVKNSDYRQLLKQFGRLGASLWQRSHGIDEREVIVERERKSVGVERTFTQNIVTYEQCWQVIEEKLFPELAIRLEKANPEKAIIKQGIKMKFADFQLTTIEHVHHELELAYFRELLQDILQRQKGREIRLLGLSVMLKPEEQARQLSLL
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_METMA
Sequence: MPKVAVGGTFQYLHDGHARLIEKAFEIAGSGKVYIGLTSDEMLQKNHSVESYKIRRSRLLEYIKKMGVPEEKYEVTRLNDPCGPTIEEDFDHIIVSPETYPVALKINTIREKKGKKPLEIVYVEYVMAEDGIPISSTRISKGEIDRHGRLKKEA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROQ_ALIF1
Sequence: MENSEKLANSKEVIAYIAERFPKCFILEGEAKPLKIGIFQDLAERLSDDPKVSKTQLRAGLRQYTSSWRYLHGVKPGASRVDLDGNPCGELEEEHIEHAKATLEESKAKVATRRKEQAKKAREEAKAKKTARAATPPKRRPQPAAKKVEQPVETRALNADEITVGNNVSVNMGKGNMPATIVEINKDDVRIRLSNGLQMVVKAENLRS
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCHL_BOVIN
Sequence: MGLSASAPAASTVQTSTPAASDHQTAAPTSGCPMHEGKVKGCPVSAEPSDSTCGSKTNSVPAHQERAYEYVQCPITGAKAANKENLDPSNLMPPPNQTPAPDQPFPLSTVREESSIPRADSDKKWVYPSEQMFWNAMLRKGWKWKDEDISQKDMYNIIRIHNQNNEQAWKEILKWEALHAAECPCGPSLIRFGGKAKEYSPRARIRSWMGYELPFDRHDWIINRCGTEVRYVIDYYDGGEVNQDYQFTILDVRPALDSLSAVWDRMKVAWWRWTS
What is the function of this protein?
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
What are the official names of this protein?
Holocytochrome c-type synthase, Cytochrome c-type heme lyase, CCHL.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-type heme lyase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Membrane; Lipid-anchor.
Protein: YE008_YEAST
Sequence: MTLSLINRSTACIQAVEQKYCRVPLPENNR
What are the official names of this protein?
Putative uncharacterized protein YEL008C-A.
Protein: BBE22_ARATH
Sequence: MRELFMYLFLLFLVLCVKSVYSTPTREQFQNCLSTKQFNSTLKNPINLTTHTLDSRVHTDFSESSSPNSSFLNLNFTSLKPILIVKPKSESEIKQSILCSRKLGVQVRTMSGGHDYEGLSYLSLSPFIIVDLVNLRSISINLTDETAWIQSGATLGEVYYKIAKTSKIHAFAAGICPSVGVGGHISGGGFGTIMRKYGLASDNVVDARLMDVNGKTLDRKTMGEDLFWALRGGGAASFGVVLSWKVKLARVPEKVTCFISQHPMGPSMNKLVHRWQSIGSELDEDLFIRVIIDNSLEGNQRKVKSTFQTLFLGGIDRLIPLMNQKFPELGLRSQDCSEMSWIESIMFFNWRSGQPLEILLNRDLRFEDQYFKAKSDYVQKPVPENVFEEVTKRFLEQDTPLMIFEPLGGKISKISETESPYPHRRGNLYNIQYMVKWKVNEVEEMNKHVRWMRSLHDYMTPYVSKSPRGAYLNYRDLDLGSTKGINTSFEDARKWGETYFKGNFKRLGLVKGKIDPTNFFRNEQSIPPLF
What are the official names of this protein?
Berberine bridge enzyme-like 22, AtBBE-like 22.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: SYH_NOCFA
Sequence: MTKTSSFSAPKGVPDYVPPGSAEFVAVRDALLRAARLAGYGHIELPIFEDTGLFARGVGESTDVVTKEMYTFADRGERSVTLRPEGTAGVMRAVIEHGLDRGQLPVKLVYSGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGFRSLGLDGFRLELTSLGDDTCRPRYRELLQEFLFGLPLDEETRRRAELNPLRVLDDKRPEVRELLADAPLMIDHLSESAKAHFEQVLGHLDALGVPYVVNPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGGQPLSGIGFGLGVDRTMLALQAEGKSAGDPARCDVFGVPLGEAAKQRMVVLAAQLRAAGVRVDLAYGGRGVKGAMKAADRSGARYTLVLGDRDLAEDTIGVKDMSTGDQRQVPLGEVVGVLRSELG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_PSESM
Sequence: MSLSRVSVTGVRNLHPVTLSPSPRINILYGANGSGKTSVLEAIHLLGIARSFRSSRLLPVIQYEQPSCTVFGQVDLAQGGHSNLGVSRDRQGEFQIRIDGQNARSAAQLAEILPLQLINPDSFRLLEGAPKIRRQFLDWGVFHVEPRFMSTWQRLQKALKQRNSWLRHGTLDAASQAAWDRELCLASDEIDEFRRAYIKALKPVFEKTLSELVELEGLTLSYYRGWDKEKELSTVLASSLNRDQQMGHTQAGPQRADLRLRLGAHNAADILSRGQQKLVVCALRIAQGHLVSQVRRGQCIYLVDDLPSELDDNHRRALCRLLEELRCQVFITCVDQEFLREGWQTDTPVALFHVEQGRITQTHDHRE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMC3_MOUSE
Sequence: MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLEHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDVITAEMAKDFVEDDTTHG
What is the function of this protein?
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle.  The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped.  At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.  Cohesion is coupled to DNA replication and is involved in DNA repair.  The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
What are the official names of this protein?
Structural maintenance of chromosomes protein 3, SMC protein 3, SMC-3, Basement membrane-associated chondroitin proteoglycan, Bamacan, Chondroitin sulfate proteoglycan 6, Chromosome segregation protein SmcD, Mad member-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions.
Protein: SYM_GRAFK
Sequence: MNKNPQRFTITAALPYTNGPIHIGHLAGVYVPADIYSRFLRMQGYDVAFVCGSDEHGVPITIKAKKEGVTPQDVVDKYNGIIKKSFEDFGITFDNYSRTSGKTHHDTASAFFKKMYEDGKFIEESTEQLYDEEAGQFLADRFVTGTCPKCGNEEAYGDQCESCGTSLNATDLINPKSAITGAVPTLKETRHWFLPLDQYEDFLKEWILKGHKSDWKSNVYGQVKSWIDDGLRARAVTRDLDWGIPVPVEGGDGKVLYVWFDAPIGYISSTKEWAEREGKDWEPYWKDENTKLVHFIGKDNIVFHCIIFPVMLKAHGDYILPENVPANEFLNLEGKKLSTSKNWAVWLHEYLEEFPDQQDVLRYVLTANAPETKDNDFTWKDFQARNNNELVAIFGNFINRVVVLTNKYYNGIVPEPGAYSEIDEKTIAELKAYPSVIASSIERYRFREAQGELMNLARLGNKYLADEEPWKLIKTDEERVKTIMYVALQIASALSIISEPFLPFTSAKLKKMLNHVDESSDNTPDWDIIGTKEALILGGHQIGKAELLFSKIEDEQMEKQLEKLEATKTANAMEDQKAEPQKEIATFEDFTKMDLRVGTIIEAQKMPKTKKLMVLKVDTGIDQRTVVSGIAEHFKAEDIIGKKVTVLANLAPRKLRGVDSEGMILMTENAEGKLVFVNPDEDGVKAGTTIN
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOM40_CAEBR
Sequence: MATPTESEFAAPIPQTNPGSYEELHRKARDVFPTCFEGAKLMVNKGLSSHFQVSHTLSLSAMNTGYRFGATYVGTNQVGPAEAYPILLGDTDVNGNTTATILHQMGIYRTKLQGQIQQGKLAGAQATIERKGRLSTLGLTLANIDLVNEAGILVGQFLRRLTPRLDVGTEMVYQYGKNIPGGQISVLSYAARYTANHFIAAATLGASGVHLTYYHKQHDNLAFGVEFECNANVGEAVTTLAYQTELPEEGVTMRASFDTNWSVGGVFEKRLSQQLPFTLALSGTLNHVKAAGKFGIGLIIG
What is the function of this protein?
Channel-forming protein essential for import of protein precursors into mitochondria.  Specifically required for nnt-1 accumulation in the mitochondria and may be involved in the secretion of daf-28/insulin from the mitochondria.  Required for embryonic and larval development.
What are the official names of this protein?
Mitochondrial import receptor subunit TOM40 homolog, Translocase of outer membrane 40 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the Tom40 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: ASB1_MOUSE
Sequence: MAEGGTGPDGRAGPGPAGPNLKEWLREQFCDHPLEHCDDTRLHDAAYVGDLQTLRNLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVNHHLTPDTRPPFSRRLTSLVVCPLYISAAYHNLQCFRLLLQAGANPDFNCNGPVNTQEFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPEARGRRKMDPEALQVFKEARSIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE
What is the function of this protein?
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  Mediates Notch-induced ubiquitination and degradation of TCF3/E2A and JAK2 (By similarity).  May play a role in testis development (PubMed:11509662).
What are the official names of this protein?
Ankyrin repeat and SOCS box protein 1, ASB-1.
What is the protein family that this protein belongs to?
Belongs to the ankyrin SOCS box (ASB) family.
Protein: GEP3_YEAS6
Sequence: MLNLCHALRGVRQFSCSVIVKVKCASCSIKLQDQDPSKPGYYTKPKSLPDSKLNPDLQDLKYLLFSQDIQLSKQAIQNDPDLKTKRDLLLRVICKRCSNALHHNNYNPEEFPESTLNDILNYVPRGSNVMHIVPFVEFPLHLDPNVLKRNDLDTTLVLTKSDQVFKDKNAVSKKVPIFMKQFLKNTLRIDSNKTFAISALKNWNISMFYNYFKNYTYLLGNPNVGKSTLINTLLQKYLGYKVKIDSTGKINSPSEEVMQEAFTNPKNFFKIQAAGVSHIPNLTRSGQAYQVGGKILFDLPGYSTSTSRLRLEEPIDERWLQRLRKTDLFNRKHIKQKTYESMKGTSQGGCYTVGGIFYLVPPKGSINQIVKYIPGPSKTFKNIEKGIDVFNSCNSSSGTHPLSRYCGIKSVICEKSQYKRYAIPPFIGSIEIVLKDIGYILLRTTGRYEFKGLHEIWIPRGIQVGIREPLENLIESGYQRYIETNGKESSCPRDRPIISSLYEMAPDEADTLNAVKKSYLEKTEKDLSARRFVDDDPYDLVQHLEKKKNPYWYYQW
What is the function of this protein?
Interacts genetically with prohibitins and thus may be involved in the mitochondrial lipid metabolism.
What are the official names of this protein?
Genetic interactor of prohibitins 3, mitochondrial, Altered inheritance of mitochondria protein 40, Found in mitochondrial proteome protein 38.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ISPG_LISMO
Sequence: MNERIFRENTRPVQVGNLTIGGSEELTIQSMTTTKTHDVEATVAEIHRLEEAGCQIVRVACPDERAANALSAIKKKIHIPLVADIHFDYRLALKAIDAGVDKIRINPGNIGRRDRVEKVVNAAKAKNIPIRIGVNAGSLEKKIIQKYGYPTADGMVESALAHIKILEDLDFYDIIVSLKASDVNLAIEAYDKASRAFNYPLHLGITESGTQFAGGIKSAAGLGAILSLGIGNTLRVSLSADPVEEIKVAREVLKSFGLSSNAAMLISCPTCGRIEIDLIRIANEVENYIAKIEVPIKVAVLGCAVNGPGEAREADIGIAGSNGEGLLFRHGKIIRKVPEAIMIDELKKEIDILAEEFFVKKIDLESLR
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: GCSH_CELJU
Sequence: MSDIRKELKYLSSHEWARVEEDGTVTIGITDHAQDALGDVVYVETPEVGSRVSLGEEAGVVESVKAASDIYSLVSGKVVAVNELLQDAPETVNSSPYDEGWFFRVQPDDVSELDEALSADEYRELLESEE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: CH60_LACCB
Sequence: MAKEIKFSEDARAAMLRGVDQLANTVKTTLGPKGRNVVLDKSYGSPEITNDGVTIAKSIDLEDHYENMGAKLVAEVASKTNDIAGDGTTTATVLAQSIIREGMKNVTAGANPVGIRTGIEKATKAAVDELHKISHKVNGKKEIAQVASVSSSNTEVGSLIADAMEKVGHDGVITIEESKGIDTELSVVEGMQFDRGYLSQYMVTDNDKMEADLDDPYILITDKKISNIQDILPLLQEIVQQGKALLIIADDVAGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAQLEDIATLTGGTVISSDLGLDLKDTKLEQLGRAGKVTVTKDNTTIVDGAGSKDAIAERVNIIKKQIDDTTSDFDREKLQERLAKLAGGVAVVKVGAATETELKERKYRIEDALNATRAAVEEGYVAGGGTALVDVLPAVAALKEEGDVQTGINIVLRALEEPVRQIAENAGKEGSVIVEQLKKEKQGVGYNAATDEWEDMAKSGIIDPTKVTRSALQNAASVAALMLTTEAVVADKPDPNANNNAAAGANPAAGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRD_CHLT2
Sequence: MTTNKSYLTYFTDALWINNQPLIAILGICSALAVTTTVTTALTMGFAVSFVTGCSSFVVSLLRKITPESVRMIAQLIIISLFVILIDQFLKAFFFTISKTLSVFVGLIITNCIVMGRAESMARHVSPIPAFLDGLGSGLGYGWVLVCISIIRELFGFGTILGFRVIPEILYASAAHPDGYENLGLMVLAPSAFFLLGIMIWIVNIIRAPKTKR
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL9_CORU7
Sequence: MKLILTTAVDKLGVPGDIVEVKAGYGRNYLLPRGYAIVATRGAEKQIKDIQRAKADRVIRDQEHAEAVKAELEALSAVQVPVRTAQGGKLFGSVTSADVVAAVERAGGPKLDKHAIKLPKNSIKNTGKYAVDVKLVSGMTANLEFAVVDADK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ATPB_CERS5
Sequence: MATASQGKVTQVIGAVVDVQFDGGLPAILNALETVNNDKRLVLEVAQHLGENTVRTIAMDATEGLVRGAPVTDLGGPISVPVGDATLGRILNVIGEPIDEKGPVSGDSTRAIHQPAPTFAEQSTTSEILVTGIKVIDLLAPYSKGGKIGLFGGAGVGKTVLIMELINNIAKVHSGYSVFAGVGERTREGNDLYHEMIDSGVIKIDNLSESKVALVYGQMNEPPGARARVALTGLTLAEQFRDQSGTDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGALQERITSTKAGSITSVQAIYVPADDLTDPAPATSFAHLDATTVLSRAISELGIYPAVDPLDSTSRILDPQIVGEEHYNVARAVQGILQRYKSLQDIIAILGMDELSEEDKLTVARARKIQRFLSQPFDVAKVFTGSDGVQVPLEKTIASFKAVVNGEYDHLPEAAFYMVGDIEDVIAKAQRLAAQAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.