PharMolix/UniProtQA huggingface dataset:
Protein: PPIL1_HUMAN
Sequence: MAAIPPDSWQPPNVYLETSMGIIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDFMIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKIIKAYPSG
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346, PubMed:33220177).  PPIases accelerate the folding of proteins.  Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688).  Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (PubMed:33220177).  Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase-like 1, PPIase, Rotamase PPIL1.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
Protein: PYRG_METLZ
Sequence: MKYVVVTGGVMSGLGKGITAASIGRILINRGYHVTSVKIDPYLNIDAGLMNPAQHGEVFVLKDGGEADLDLGNYERFLDIELTSDHNLTTGKIYSSVISKERHGDYLGATVQIIPHITDEIKDRIKHAAESWVDKDGNHAEICIVEVGGTVGDIESMPFLEAVRQMHWEYGNGDFALVHVTLLPADTMGDLKTKPTQHSIKALRELGLEADIIVGRSNLPVSLSTKRKISSFCDVDVHAVISAQTAPDTYLVPMELEKEGMADVLLKQLHLESGKTDNGWYSLVARDYTSRITVGIITKYGVEDVYISIKEALKHAGRHLSTEVVIHWLDAELYTPEDLADLDGILIPGGFGNRGIEGMISAIQYAREHKKPLLGLCLGFQLCVIEFMRNVVGYWDATSEEMGAGTHAIALLPEQEGVEDLGGTMRLGDYPVTLDPASRLAELYGATEIVERHRHRYEVNPTYIDEIEAKGMKFVGKNGRRMEALELADHPYFVATQFHPEFRSRPARPSAPFIGFVKACREMKRKE
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: MOG1_CAEEL
Sequence: MSDKRADGRLEGTSDTFGGLVIKKKKVEGDSKPTEPSGKSLLGLDRLASTKREHARKRLEDDDDRGVTESVRKGIEKVHEKHRDRDDRGMKYKSRDDDRRRDRDRSERREPSSRRGWKDRSGDQTPRFKVPDTPSRMSWDQDDREGSSRKRNSWDMPTPRGERDRKRYMDSERSISSAWRSERRNRDDEKRRRHRKPEDSVRSVKEEKAEPTFHDDEERAQWEEEQKNLDREWYDNEGAFDDEYNPFNKVSDEFVEKREKQWQEKTQKPRLTVKQQAIKRENELWENNRLHRSGVVAMADELSSIFEDETDENRVTILVQNIVPPFLDGRIVFTKQAQPIIPVVDTTCDMAVSAARGSVAVRKRREVEDRKKAQDKHWELAGSKLGNLMGVKEKKDETADPEDDDSGNYKESHQFASHMKDNEAVSDFAMEKSIKQQREYLPVFACRQKMMNVIRENNVVIIVGETGSGKTTQLAQYLLEDGFGDSGLIGCTQPRRVAAMSVARRVADEMGVDLGQDVGYAIRFEDCTSEKTIIKYMTDGILLRECLGDGSLDQYSAIIMDEAHERSLNTDVLFGLLREVIAKRADLKLIVTSATMDADKFADFFGGNCPTFTIPGRTFPVELFHARTPVEDYVDAAVKQAVTIHLGGMDGDILIFMPGQEDIECTCEMIKEKLGELDEAPPLAVLPIYSQLPSDLQAKIFQRAPGGMRKAIVATNIAETSLTVDGILFVIDPGFCKMKVYNPRIGMDALSIFPVSQASANQRTGRAGRTGPGQCYRLYTERQFKDELLKSTVPEIQRTNLANVVLLLKSLGVDDLLKFHFMDAPPQDNMLNSMYQLWTLGALDNTGQLTPMGRKMVEFPLDPTLSKMLIMSAEMGCSDEVLTIVSMLSVPAIFFRPKGREEEADAKKEKFQVPESDHLTFLNVYIQWRTHKYSAKWCADNYLHVKALKKVREVRAQLKEIMQDLKLPLISNGSEWDIVRKCICSAYFHNAARLKGIGEYVNVRTGIPCFLHPTSALFGMGFMPDYVVYHELIMTAKEYMQCVTAVDAIWLAELGPMFYSIKESKQSRKELKMESVRTVETMEAEMREAQKEMERRKEESDKAFKRPESSRRVVEVGSKSARSERRKLWGL
What is the function of this protein?
Probable ATP-binding RNA helicase involved in pre-mRNA splicing.
What are the official names of this protein?
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1, Masculinization of germline protein 1, Sex determination protein mog-1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: METK_XANC8
Sequence: MSSYLFTSESVSEGHPDKIADQISDAVLDAILAQDKRARVACETMVKTGVAIVAGEVTTSAWIDLEALTRKVILDIGYNSSDVGFDGETCGVLNLIGKQSPDINQGVDRKNPEQQGAGDQGLMFGYATNETDSYMPAAIHLSHRLVEQQAKIRKKKNSALSWLRPDAKSQVTLRYEDGVATAIDAVVLSTQHDPGVKQKDLIEAVREEILKPVLPAKWLHKGTKFHINPTGKFVIGGPVGDCGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAARYVAKNVVAAGLADRCEVQVSYAIGVAEPTSISVTTFGTGKIADELIEKLIRKHFDLRPFGIIQMLDLIHPMYQQTASYGHFGRKPKDFTYTDGTGAQHSATSFSWEKTDRAEALRAAAKLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTFE_YERPN
Sequence: MDYRNQSLGALAIAIPRATKLFRQHQLDFCCGGKQTLLRAANKLNLDIDALEAQLSALQTEPHSSEDWQQQPLTNLISFIISRYHDRHREQLPELVLMAEKVERVHGEKPTCPRGLAAELSAILEELTQHMYKEEQILFPMIQRGMGSQASGPIFVMEAEHDAVGQQLDVVKQLTQNVTPPEGACNTWRALYTGINEFITDLMEHIHLENNLLFPRALRGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_LEUMM
Sequence: MALTQERKNEIIKAYARHEGDTGSAEVQIAVLTADINELNTHMAAHKHDFHSQRGLMKKIGSRRNLLRYLRNTDIQRYRELIQRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RSMA_CLOD6
Sequence: MDRLSSHNATKEVVQKYNFKFSKSLGQNFLIDSNIIDKILSGARITRGDNIIEVGPGIGTLTREMGKIAEKVVAIEIDRNLIPILKDTLSDLDNTEVVNQDILKVDIQELVKDKLNGGPVKLVANLPYYITTPIVMKFLEEDIPVTDIVVMVQKEVADRMNAIPGTKDYGALSIAVQYYCDTEIVAKAPRHMFIPQPNVDSTVIGLHVRDKRKYDVHNEDIFFKTVKASFGQRRKTLLNSLGGLGFLNKDEIREILKEANIDEKRRGETLSIEEFSVLSNIINTKVSSK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHMG_PHANO
Sequence: MTNSSPPFSTIHQFFPGNTFLNFESVRILSTAPYGGCDAAEFLTAIAAINPKDPQTWADAWSHMAHLAETMAEEALSRGDVVAARDGFLRASSYTRASGYLYINGPTLDEHHPLAFEISKKVQSLFRRALPFLDCDVHVVEIPYVVDSPERKEVMLPGYLYLPNAQHRLPDGKIPVLLNTGGADSVQEELYYIHPQGGHTRGYAVLTFEGPGQGIVLREHGLHMRPDWEVTGWKGYSSTLKREVGVELDLDRIAVAGASMGGYYALRAAKDSRIKACVAIDPFYDMWDFGTKHISGLFMSAWTGGWIGDDWVDRIIRLGMRTNFQLRWEVGVTAAFWGIASPAKILKEMSKYSLKGGYLEKVQCPVLVTGAGKSLYFDTEEHTMKVFDDLGHLEERWRRVWMPNRPEEGGLQAKIGAFGLANMKAYGFLDEVFGIRRVTVES
What is the function of this protein?
Hydrolyase; part of the gene cluster that mediates the biosynthesis of the mycotoxins phomacins, leucine-derived cytochalasans with potent actin polymerization-inhibitory activities and monocot-specific antigerminative activities (PubMed:31815421).  The first step in the pathway is catalyzed by the hybrid PKS-NRPS phmA, assisted by the enoyl reductase phmE, that are responsible for fusion of the leucine precursor and the polyketide backbone to produce a 2-pyrrolidone intermediate (PubMed:31815421).  The polyketide synthase module (PKS) of phmA is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the leucine precursor (PubMed:31815421).  Because phmA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase phmE (PubMed:31815421).  Reduction by the hydrolyase phmG, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase phmD then yield the required isoindolone-fused macrocycle (Probable).  A number of oxidative steps catalyzed by the tailoring cytochrome P450 monooxygenase phmB, the FAD-linked oxidoreductase phmC and the short-chain dehydrogenase/reductase phmF, are further required to afford the final products, phomacin D and phomacin E (PubMed:31815421).
What are the official names of this protein?
Hydrolase phmG, Phomacin biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.
Protein: HIK34_SYNY3
Sequence: MNEVCLKLSDLFVSSGWGGYDRGRAPQWAHPRAQQQWFGAIAALEPFLRQTLPNVGGELPGICLTGPAPVLKDAVLVRNFYQGIATPWEEFSPWPCLAGEESEWSAVPPMREIPLFPQDPLAEEQFCWLMTPQFGLLLLLGKNEQGLAQFYWTFDPEILQQAWLSLQARLKYGLSPDLSLLQKTIAAFNFPQPDFRLVTYFGQLMLDYQPNPYNLPPCQEQESAEPSPDVELLQALTHEVRTPLTSIRTLTKLLLRRKDLSPEVLKRIESIDRECSDQISRMDLIFRATELESTPLPELVVPLTVTSLEAVFQAGIPRWQKQAQRYNVNLQAQIPHSLPQVWSNPSLLDQVLGGMIEKFVRNFNGGGEINLQITTAGDQLKVQFHTQSVHQANPVRALGELLMFQPQTGCLSLNWDVTKNLFQLLGGKLIVRRRSPSEEILTIYLKCEQRTVPVANYDRQFTMV
What is the function of this protein?
Member of a two-component system Hik34/Rre1, controlling expression of at least 20 genes in response to hyperosmotic stress (0. 5 M sorbitol) or salt (0. 5 M NaCl) (PubMed:15471853, PubMed:15805106, PubMed:19411329).  Represses expression of heat shock genes under normal growth conditions (PubMed:15965020).  Required for survival of long-term heat shock exposure (PubMed:25738257).
What are the official names of this protein?
Sensor histidine kinase Hik34.
Protein: PSAB_SOYBN
Sequence: MALRFPRFSQGLAQDPTTRRIWFGIATAHDFESHDDITEERLYQNIFASHFGQLAIIFLWTSGNLFHVAWQGNFEAWVQDPLHVRPIAHAIWDPHFGQPAVEAFTRGGALGPVNIAYSGVYQWWYTIGLRTNGDLYTGALFLLFLSTISLIAGWLHLQPKWKPSVSWFKNAESRLNHHLSGLFGVSSLAWTGHLVHVAIPGSRGEYVRWNNLLSILPHPEGLGPFFTGQWNLYAQNPDSNSHIFGTPQGAGTAILTLLGGFHPQTQSLWLTDIAHHHLAIAFLFLVAGHMYRTNFGIGHSIKDLLEAHTPPGGRLGRGHKGLYDTINNSIHFQLGLALASLGVITSLVAQHMYSLPAYAFIAQDFTTQAALYTHHQYIAGFIMTGAFAHGAIFFIRDYNPEQNEDNVLARMLDHKEAIISHLSWASLFLGFHTLGLYVHNDVMLAFGTPEKQILIEPIFAQWIQSAHGKTSYGFDILLSSTNSPAFNAGRSIWLPGWLNAVNENSNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWVTFYWHWKHITLWQGNVSQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLSVWAWMFLFGHLVWATGFMFLISWRGYWQELIETLAWAHERTPLANLIRWRDKPVALSIVQARLVGLAHFSVGYIFTYAAFLIASTSGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: RBFA_AERHH
Sequence: MAREFSRTRRVGQQIQREIALILQREVKDPRIGMVTVSDVEVSRDLNYAKVYVTFLQLENDAERIKEGLKALTEAAGYIRSLLGSAMRLRVVPELRFFYDQTLVEGMRLSNLVTNTIREDKRRMAESGREEDDAAPDETTEDNA
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_LACH4
Sequence: MNILGMKLFAHHKGGGSSANGRNSAGRRLGAKAGDGQTIHAGTIIYRQRGTKIHPGKNVGQGGDDTLFALVNGVVKFERLGKYKKQVSVYPAEEAK
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: T1SB_MYCPN
Sequence: MQIRTYKIKDICDIQRGRGITKEYIKNNSGKYPVYSAATTNNGELGFINTYDFAGEYVTWTTNGYAGVVFYRNGKFSASQDCGVLKVRNKEINAQFLAFALSLKTPQFVHNLGSRPKLNRKVVAEISLDFPPLEVQEKIAHFLKSFNELSSQLKAELIKRQKQYAFYSDYLLNPKHSQGEEYKLFKLKDIAKKILVGGEKPSDFQKEKDQVYKYPILSNSRKADDFLGYSKTFRIAEKSITVSARGTIGAVFYRDFSYLPAVSLICFIPKPEFNINFLFHALKATKFHKQGSGTGQLTMAQFKEYQVYIPSLKKQQEIAATLDPLYYIFANSNWGIYKEIELRKKQMQYYQERLFQWIENQKV
What is the function of this protein?
The specificity (S) subunit of a type I methyltransferase (MTase); this subunit dictates DNA sequence specificity.  The single R subunit has multiple frameshifts and is probably not expressed.
What are the official names of this protein?
Putative type I specificity subunit S.MpnORF507P, S protein, S.MpnORF507P, Putative type-1 restriction enzyme specificity subunit MPN_507, S.MpnORFBP.
What is the protein family that this protein belongs to?
Belongs to the type-I restriction system S methylase family.
Protein: RS2_SHEPW
Sequence: MTTVSMRDMLQAGVHFGHQTRYWNPKMKPFIFGARNGVHIINLEHTVPMFNEALAFISNIASKKGKVLFVGTKRAASEAIKEAAVSCDQFYVDHRWLGGMLTNWKTVRQSIKRLKDLESQSIDGTFDKLTKKEALMRTRELEKLEKSLGGIKNMAGLPDVIFVIGADHEHIAIKEANNLGIPVVAVVDTNSSPDGINYIIPGNDDAMRSIRLYTESVATAAKAGRNQDLAVQAEQDGFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: YPP4_CAEEL
Sequence: MKLLALVALCAVGVASHRDKRQLSIGTISVSGAGGSTGCVVTGNVLYANGIRLRNLTSSEQSELATYQTEVEQYKTQLRNILSQRRENLRNRLMSQGRNQQQQSNDVSSQGGNDDGSIPKAPEKPSFCTAEDTTQYYFDGCMVQGNKVYVGGQYARDLSSDEISELQTFDTQQTAYQNAVQSQMQSQVQGLFGGSDFLSALFGGDRFNQQQQRQQPSSTTPASTSSTTLPPKPTVPQFCTAIF
What are the official names of this protein?
Uncharacterized protein F32A5.4.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I33 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PURA_GLOC7
Sequence: MANVIVIGAQWGDEGKGKITDLLSRSADVVVRSQGGVNAGHTVVVQGQTFKLHLIPSGILYPDTECIIGSGTVIDPSVLLEEMEQLHALNVSTENLFISQTAHITMPYHRLIDRASEERRGKYKLGTTGRGIGPTYADKSERTGIRVVDLMNGDDLQEKIEWTINYKNAILEKLYNLSPLDPKQVIDEYRGYAEQLRSYVIDSSLKIYEAIQQKKNILFEGAQGTLLDLDHGTYPYVTSSNPIAGGACVGAGIGPTVIDRVIGVAKAYTTRVGEGPFPTELNGEIGELLCDRGAEFGTTTGRRRRCGWFDAVIGRYAVRINGIDCLAITKLDVLDELDEIEVCVAYELDGQICDHFPSDANQFARCQPIYRTLPGWKQSTTNCRSLEDLPKQALDYLKFLAEVMEVSIAIVSLGASRDQTIIVEDPIHGPKRALLDENGVPVSKADTQE
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_MYCLB
Sequence: MKANIHPAYAETTVVCGCGNTFQTRSTKPGGRIVVEVCSQCHPFYTGKQKILDSGGRVARFEKRYGKRKVGVDQVAAYPEQNNK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RT04_PROWI
Sequence: MKISLKCLNTHTAEIYRKCLLLSDSTVNVSSVDFTNQSKLNLLKQEKKSIESFNKNSLLNISNFRDLERQEKDIQKKTSKKVYKKSYSRSTKSIYSRTKIINERNKLHTLNQQIIFSTLARIHLKKKINLLFPVQEFLFELSKHRNKSAGSKSREYLEILLCVKKLKMFYGFIPLKQLHKILVQAKAMPGYFSKNFFSLIEKRLDVVLYRSGFTKTIVAARQACRHSQIYVNSKVCRIPSTILESGDIISYKNQLDSLKTAEIKNNLFSNINTNVSGNEVSNNVSNKVSNKISSTLALNKQSLLLLLFCAKSIYNESFFVSNKRKFKSNEVTFDNKKEITSAIDYTKYLQIKNSRKKYKLITLNNNLDSLSFNIFDKEILNSLSSKQNLPVNKQNIVEIENKKTNKFNTFSLLFQNLTSFSKSIESYSSVLALKLQDHLLNIKGKRNEVSKNINKIERSQKDNVFINILQKINRPTHLEISSITNSIIFLYSPQRIYLPFYVDIDILRKSL
What are the official names of this protein?
Ribosomal protein S4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ANT3_SHEEP
Sequence: MISNGIGTVTTGKRSMCLFPLLLIGLWGCVTCHRSPVEDICTAKPRDIPVNPMCIYRSPEKKATEGEGSEQKIPGATNRRVWELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLKQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSELVSANRLFGDKSITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAIDEFTVLVLVNTIYFKGLWKSKFSPENTKKELFYKADGESCSVPMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKLEKPLAKVERELTPDMLQEWLDELTETLLVVHMPHFRIEDSFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRNDLYVSDAFHKAFLEVNEEGSEAAASTVISIAGRSLNLNRVTFQANRPFLVLIREVALNTIIFMGRVANPCVN
What is the function of this protein?
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade.  AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa.  Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).
What are the official names of this protein?
Antithrombin-III, ATIII, Serpin C1.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: FBPC_PHOPR
Sequence: MENDNFVVLKNVCKRFGDNTVINNLDLEIKKGSLVTLLGPSGCGKTTVLRLVAGLEKPTSGQIFIDGEDVTNTSIQQRDICMVFQSYALFPHLSLYDNVGYGLKMLKLPAAEIKQRVDDALKLVDLSGMGDRFVDQISGGQQQRIALARALVLKPKVLLFDEPLSNLDANLRRSMRETIRDLQQRFNITSLYVTHDQTEAFAVSDTVIVMKDGEIMQQGSPDDLYKTPSSMFMANFMGDANIFTGRYDDGQLNINGYCIPADPEVVQGKAEGDYQIGVRPEAILLTSEGEPSQQCIVNNVVYMGSMYEVAVTWHDQELLLQLNSSQFDANLSDHAYLTINPTGIFLLPFDA
What is the function of this protein?
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Fe(3+) ions import ATP-binding protein FbpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL6_DESAH
Sequence: MSRIGKKPVQIPEKVEVSVKGDLISIKGPKGSLDRSLHPAVKLAIENGMVNVSVTDDQDRKTVALQGLFRSLVANMITGVSVGYEKKLLLNGIGYRAEVNGNTVVLNVGYSNPVNFELPKGISALVEKNTTLSLSGIDKEIVGETAARIRRIRPPEPYKGKGIMYSDERIIKKAGKAAAK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: GPMA_BURP0
Sequence: MYKLVLIRHGESTWNKENRFTGWVDVDLTEQGNREARQAGQLLKEAGYTFDIAYTSVLKRAIRTLWHVQDQMDLMYVPVVHSWRLNERHYGALSGLNKAETAAKYGDEQVLVWRRSYDTPPPALEPGDERAPYADPRYAKVPREQLPLTECLKDTVARVLPLWNESIAPAVKAGKQVLIAAHGNSLRALIKYLDGISDADIVGLNIPNGVPLVYELDESLTPIRHYYLGDQEAIAKAQAAVAQQGKSAA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: GBRA1_MACFA
Sequence: MRKSPGLSDYLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity).  The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).  The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (By similarity).  GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity).  Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
Protein: OMD_MOUSE
Sequence: MGFLSPIYVLFFCFGVRVYCQYEAYRWDDDYDQEPNEDYDPEFQFHQNIEYGVPFYNNILGCAKECFCPTNFPTSMYCDNRKLKTIPIIPMHIQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLSNLQQLHLEHNNLEEFPFPLPKSLERLLLGYNEISILPTNAMDGLVNVTMLDLCYNHLSDSMLKEKTLSKMEKLMQLNLCNNRLESMPLGLPSSLMYLSLENNSISSIPDNYFDKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPRNLEHLYLQNNEIESINVTMICPSPDPVHHHHLTYLRVDQNKLKEPISSYIFFCFPRIHSIYYGEQRSTNGETIQLKTQVFRSYQEEEEEDDHDSQDNTLEGQEVSDEHYNSHYYEMQEWQDTI
What is the function of this protein?
May be implicated in biomineralization processes.  Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin.
What are the official names of this protein?
Osteomodulin, Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, Osteoadherin, OSAD.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: YBEY_SALAI
Sequence: MSIEIANESGVDIDTDAVLAVARHALDEMGVNQLAELSVLLVDIDYMAELNHRWMGGDGPTDVLAFPMDEGSVDHGPGESAVAGTEPALLGDIVLCPEVAAKQAATAGHSAADELHLLTVHGVLHLLGYDHAEPDEEREMFALQARLLAGWRSTRST
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.