PharMolix/UniProtQA huggingface dataset:
Protein: MIAA_CERS5
Sequence: MLPPLPIPPDRPVLIAGPTASGKSALAAEIVGRDGGVVVNADALQVYDCWRILSARPSVAEEAALPHRLYGHVPRRGIYSAGHWLKEVEAVLREGLRPVIVGGTGLYFSSLTNGLADIPHTPPEMRHEADAFLARAGLSAMVADLDPATAGRIDLRNPARVQRAWEVLRATGRGLADWQAATGAPLLPLAETVALVLRPDRDWLAERIDRRFDLMIEAGALEEARVALADWDPALPSSRAIGAPELVAHLKGERTLDEAIAAAKLASRQYAKRQRTWFRNRMRDWREIRLP
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: KTHY_HELPY
Sequence: MYVVLEGVDGAGKSTQVELLKDRFKNALFTKEPGGTRMGESLRRIALNENISELARAFLFLSDRAEHTESVIKPALKEKKLIISDRSLISGMAYSQFSSLELNLLATQSVLPAKIILLLIDKEGLKQRLSLKSLDKIENQGIEKLLHIQQKLKTHAYALQEKFGCEVLELDAKESVKNLHEKIAAFIKCAV
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RS9_EXIS2
Sequence: MADVRYYGTGRRKHAAARVFLVAGDGKVTVNGRDISEYFGYETLIMTAKEPLVLTETEGKYDIMVTVKGGGFTGQAGAIRHGISRALLQADPDFRGTLKAKGFLTRDARMKERKKYGLKAARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: CEMA_ORYSI
Sequence: MKKKKALPSFLYLVFIVLLPWGVSFSFNKCLELWIKNWWNTRQSQTLLTAIQEKRVLERFMELEDLFILDEMIKEKPNTHVQNPPIGIRKEIIQLAKIDNEGHLHIILHFSTNIICLAILSGSFFLGKEELVILNSWVQEFFYNLNDSVKAFFILLVTDFFVGFHSTRGWELLIRWVYNDLGWVPNELIFTIFVCSFPVILDTCLKFWVFFCLNRLSPSLVVIYHSISEA
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
What are the official names of this protein?
Chloroplast envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: SSRG_MOUSE
Sequence: MAPKGGSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVLVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK
What is the function of this protein?
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
What are the official names of this protein?
Translocon-associated protein subunit gamma, TRAP-gamma, Signal sequence receptor subunit gamma, SSR-gamma.
What is the protein family that this protein belongs to?
Belongs to the TRAP-gamma family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HFW1_DROPS
Sequence: MLLTTGHARARPEQQQASADEPLEAKPEDGHSLTAPRPADDELATVAPTTTPVPAVAITQGATTGAATEATHSQPVVTAVPATSSTSTSTTVPAPLLPAAPEQPEYLKHCFYADEHLCMYGHDGQGNEAPDVLGHISTTPESDSQGIGLQVNASQGNSQNLERNANSCQCHEHPAKANSWYCCNISQMSMISSCSNISKWTNLHVRNLTVRTIDLSNPIFRSLQSLAVTDGNITRLINAFPRHSALKCLNISNNNISEIPSRMFKDVPHLEFFGMSRNNLSLVPHHNQNKNITVDISGNMRMLCNPLNEIINNDSFNFVNPKHSYCLYNATHEWFQSTDLVSVEQLESTKRCMTKCPVIPNYGSCKCRFESIMIIQDDQSKPKCHVDCSNLGLVELPPRLPDNTFVLNITNNKITSLGDHFQTNPTYHNINRLVADNNQISSIYEFEGTKFIENFQRIYMRNNSLSKIPEYFLNNALMDTGRRIYLAGNKLQCDCNSAKTLQNWLKERSTDIPDYMEIRCRNIPQSVIELQEAKLCQSPPDWTDYIYYLIAAEVILLLGLITKVSYDYWVFKTSGYLPWPASKMPKLPCDWLCES
What is the function of this protein?
Has a role in the ecdysone induced cascade; probably indirect control of 'late' ecdysone genes.
What are the official names of this protein?
Protein halfway, Protein singed wings.
Protein: Y306_SIRV1
Sequence: MKIVFGIVSSQDLLIKINFPILINQLRNKKITWKNETWVDSGGYQIALYNLKISVKDVLEKYKTYNAYAFFSLDIPSIFSPLDRKNFEYFEYLYTKMEYIERIIPVIHLYPTREVDEAIDFYSQYTDYIAFGGIIASSKLKILIYTFPWYYYIRKYVKRLHVLGMSAPYFLQIFDTANSMDTTTYTKTASYREIFWFDGTRRYVGDRKERTLTKEEEEKLFEFLDKTNFPFEYDFSNVKILKTMNAWILKYNNWNIKNKYTIYAEKLRKMGLDSLVTEIIQNYKIANELKKEKQQNKKKNSIELEE
What are the official names of this protein?
Uncharacterized protein 306.
Protein: CAN3_HUMAN
Sequence: MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
What is the function of this protein?
Calcium-regulated non-lysosomal thiol-protease.  Proteolytically cleaves CTBP1 at 'His-409'.  Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329).
What are the official names of this protein?
Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: CTNB_DICDI
Sequence: MMIKYITIAILFIASLVKADLQFSLCPTCVDFINNDMGDLEKIISGGIATSCGAVCSLLPNNIEQGACNLLCDIVGIDEFLKVFNNIGEDADPVWICEELTVCPKNQNSNATVLTSDVSPASGPHGTTFTIGVAYKVESTLGTGEVAVMVTDPTGSNGFGDAQLIVNTQPGQYSTSFSFAATPSEDEQFPAGVYQVQLMICEGSCGAKHSVTFNSVYANFTVTSGPSVTGQMTGTGSGSGSGSGSSSGAAYLRY
What is the function of this protein?
Cell-counting factor that limits the minimum size of the multicellular structure.  May up-regulate the expression of both gp24 and gp80, which mediate cell adhesion.
What are the official names of this protein?
Countin-2.
What is the protein family that this protein belongs to?
Belongs to the countin family.
Protein: PROA_SALTO
Sequence: MSVVEQAQRARTAAAALAVATRADKDAALHAMADALVARTSEILAANGADLAAGRDEGLSTAILDRLALDAGRVADIADALRQMAALPDPTGEVVRGSTLPNGLQLRQIRVPFGVVGIIYEARPNVTVDAAGICLKSGNAVLLRGSSSAARSNVALVSVLRDAVAGTGLPADSVQLLDATTRDSVKELMRARGLVDVLIPRGGAALIRTVVEEATVPVIETGVGNCHVYVDAAADVSKAVAIALNAKTQRLSTCNTAESLLVHTAVADAVLPPALAAFAAAGVTVHGCPQVARHSTAVLPATDEDYATEYLSADISVAVVESLDAAVAHIQRYGTGHTEAIVTDSQSAAREFVARVDAAAVMVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLPELTSTKYVVTGDGQLR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y439_MYCGE
Sequence: MKLRKIFLLPLISLSTLSVACSSTDPGLEKAQAYFQRNNIELSKNNAVTFLKKGYSSDKEEVINTVFASWKTTLLDYQLLEKPLDYSRFAKAFGVNKSKEDVTPNISAKGLYFDETYPGISGQIALVLGVKSQKVVNFQYSWKNNLDFKVQIHLKMTGIVGSDNTSTSLIKSFLASTSGVSESDFTGDKANFDGDVIFTYTPPTDNRRVSESTFSSIPASINFPFDIKIDMSTSHEKLNLLLSTNEQVKKIRTRTFKGKSIDLLPFFYYTLL
What are the official names of this protein?
Uncharacterized lipoprotein MG439.
What is the protein family that this protein belongs to?
Belongs to the MG439/MG440 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PUR9_FUSNN
Sequence: MRKRALISVYDKTGILDFAKFLVSKGIEIISTGGTYKYLKENNIEVIEVSKITNFEEMLDGRVKTLHPNIHGGILALRDNEEHMRTLKERNIDTIDYVIVNLYPFFEKVKEDLSFEEKIEFIDIGGPTMLRSAAKSFKNVVVISDVKDYESIKEEINKSDDVSYEARKKLAGKVFNLTSAYDAAISQFLLDEDFSEYLNISYKKFMEMRYGENSHQKAAYYTDNMTDGAMKDFKQLNGKELSYNNIRDMDLAWKVVSEFDEICCCAVKHSTPCGVALGDNVEGAYKKAYETDPVSIFGGIVAFNREVDEATAKLLNEIFLEIIIAPSFSKAALEILTKKKNIRLIECKNKPSDKKELIKVDGGILIQDTNNKLYEDLEVVTKAKPTSQEEKDLIFALKVVKFVKSNAIVVAKNLQTLGIGGGEVSRIWAAEKALERAKERFNATDVVLSSDAFFPFKDVIELAAKNGVKAIIQPSGSVNDKDSIEECDRNNISMIFSKLRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: CSOS1_SYNPW
Sequence: MANETMGIALGMIETRGLVPAIEAADAMTKAAEVRLIGREFVGGGYVTVLVRGETGAVNAAVRAGADACERVGDGLVAAHIIARPHREVEPALGNGNFLGQKD
What is the function of this protein?
One of shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, ccbL-ccbS) is sequestered.  Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome.
What are the official names of this protein?
Carboxysome shell protein CsoS1.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family. CsoS1 subfamily.
What are the subcellular locations of this protein?
Carboxysome. Note=This bacterium makes alpha-type carboxysomes.
Protein: GUN1_ORYSJ
Sequence: MARRGGAAASSSMANLLGVALVLAATAQTSARGGGGGGRHDYRMALSKSILYFEAQRSGVLPGNQRIAWRANSGLADGKANGVDLVGGYYDAGDNVKFGFPMAFTVTMMAWSVLEYGKQMAAAGELGHAMDAVRWGADYFVKAHPAPNVLYGEVGDGDSDHVCWQRPEDMTTSRQAYRLDPQHPGSDLAGETATALAAASLVFRSSNPGYANQLLQHSKQLFDFADKYRGKYDDSMPVVKKFYGSFSGYGDELLWASAWLYQATDNRRYLDYLANNGDALGGTGWATNEFGWDVKYPGVQVLAAKFLLQGKAGPHAAVLRRYQRNADVFACSCLGKGGGGGNVGRTPGGLMYHQGWNNLQFVTGASFLLAVYADHLAAAGRGQAVVRCQAGPAARASELVALAKSQVDYILGSNPRGISYMVGYGARYPRRAHHRGASIVSIRANPSFVSCKDGYASWFGRAGSNPNLLDGAVVGGPDGRDGFADERNNYQQTEVATYNNAPLMGVLARLAGGGRGGLAEAAIKRPDNQTLLPPLAAAASPVEITQLNATASWKKDGRTYRRYAATVSNRSPAGGKTVEELHIGIGKPHGPVWGLEKAARYGYVLPSSLAAGESAAFAYVVRGRAAPPPADVWVIGYKLV
What are the official names of this protein?
Endoglucanase 1, Endo-1,4-beta glucanase 1, OsCel9B, OsGLU7.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 9 (cellulase E) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CCA_VIBCH
Sequence: MQIYLVGGAVRDQLLQLPVYDRDWVVVGSSPQAMLAAGFQAVGKDFPVFLHPNSKEEHALARTERKTSVGYTGFACHYAPDVTLEEDLLRRDLTINAMAQDNSGQLIDPYGGQRDLAAKVLRHVSPAFVEDPLRVLRVARFAAKLHHLGFTVAEETMQLMAKIAQSGELQHLTAERVWQEWHKSLSAHHPEMFLQVLRDCGALAVVLPEIDRLFGVPQPEKWHPEIDTGIHTLMVAKQAAQLSDSLLVRFAAQVHDLGKGVTPPSEWPRHKLHCHTGLNIIESLCERIRVPNEFRDLALAVCAQHSNIHRADELKPTTKLKVLGLLDVWRKPERLEQVLLCCEADHRGRLGLESEPYPQREIFLRAYQAALGVAVQAVIADGFQGKHIKEELDKRRVSAIEAL
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: MOAA_CAMC1
Sequence: MLIDKYGRVVDYLRISVTQRCNFRCRYCMPTTPFSWTPKENLLTFEELFLFVKVAIDEGVKKIRITGGEPLVRKDLDVFIKMISDYKPDIDLALTTNGFMLPHFAKRLKDAGLKRINMSLDTLNEQKAKFIAQKSVLHEVLAGFEAALDAGLKVKINTVALKGFNDDELVNLLEFAKFRNSQIRFIEYMENSHAKEDLKGLKSDEILKIISQKYNVTKDEKLPNAPASIYRLDDGYKFGIIDPHKHDFCESCNRIRLSAEGLLIPCLYFEDALSIKKAVANGDIVAASEILRQVLANKPKENKWALGAENETSSRAFYQTGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: FIBA_HUMAN
Sequence: MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
Protein: FTSH_GUITH
Sequence: MKISWKNILLTLIPLGLISFLVWQGFNNTTNPQFTKNIASSRMTYGRFLEYLDLGWVKKVDLYDEGHTAIVEAIGPELGNRIQRIRVELPATAPELITKLRKANVDLDAHATNDSTPAWSLIGNLIFPILLIAGLAFLFRRSSNLPGGPGQAMNFGKSKARFQMEAKTGVTFNDVAGVDEAKEEFEEVVSFLKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAGVPFFSISGSEFVEMFVGVGASRVRDLFKKAKENSPCIVFIDEIDAVGRQRGTGIGGGNDEREQTLNQLLTEMDGFEGNTGIIIIAATNRVDVLDAALLRPGRFDRQVTVDVPDVKGRLEILNVHARNKKLDLSISLELIAKRTPGFSGADLANLLNEAAILTARRRKKQITISEIDASIDRVIAGMEGKALVDSKTKRLIAYHEVGHAIIGTLLKHHDPVQKVTLVPRGQAKGLTWFTPSEDQSLISRSQILARIMGALGGRAAEEVVFGLPEVTTGAGNDLQQVTSMARQMVTRFGMSNIGPLSLESQNSDPFLGRTMGSSSQYSEDIASRIDMQVRAIIQHCHTETVQIIKDNRVVIDKLVDLLIEKETIDGDEFRQIVGDFTSLPEKIDYKSQLKST
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein; Stromal side.
Protein: ASGR1_HUMAN
Sequence: MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL
What is the function of this protein?
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed.  The receptor recognizes terminal galactose and N-acetylgalactosamine units.  After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated.  The receptor then returns to the cell membrane surface.
What are the official names of this protein?
Asialoglycoprotein receptor 1, ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1.
What are the subcellular locations of this protein?
[Isoform H1a]: Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Isoform H1b]: Secreted.
Protein: RS26_ENCCU
Sequence: MRRNHGRGKKNRGSAGSIQCDKCGSVTPKDKAIKRFRIQSLIEQASFDDLKQATIYDVFEVPRMGYKSQFCVSCACHAKIVRVRSSQARKIRYGFNPNRVASAHN
What are the official names of this protein?
40S ribosomal protein S26.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS26 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWI3_SCHPO
Sequence: MSTAASDSGVEKLVEENKREEVKKNEEEKEFDLGLEENPDSVKKPRKRLAKFDEERLISENGIPKLRKMMRKVKLKGKGHEAKDLKQLLGMYHIWTHELYPRATFDDSISYLKTLGKHRSVKVRRRGWINEIAVENGSDSNASLFTGPSSNSLVNLTSGDPYVQDTADDAFVAQDNDTQLE
What is the function of this protein?
Forms a fork protection complex (FPC) with swi1.  FPC coordinates leading and lagging strand synthesis and moves with the replication fork.  It is required for programmed fork-pausing which is necessary for mating-type switching.  FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors.  It is involved in termination at the mat1-proximal polar-terminator of replication (RTS1) and also required for activation of the Rad53-like checkpoint kinase cds1.
What are the official names of this protein?
Swi1-interacting protein swi3, Replication fork protection complex subunit swi3.
What is the protein family that this protein belongs to?
Belongs to the CSM3 family.
What are the subcellular locations of this protein?
Nucleus. Note=Nuclear throughout the cell cycle. Associated with chromatin during S phase.
Protein: AC4CH_ECO8A
Sequence: MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELIKVIADIYPGQTQFYVIEFKCL
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: ARGHX_STRVI
Sequence: MTESPTTHHGAAPPDSVATPVRPWSEFRLTPAEAAAAAALAARCAQRYDETDGPEFLLDAPVIAHELPRRLRTFMARARLDAWPHALVVRGNPVDDAALGSTPVHWRTARTPGSRPLSFLLMLYAGLLGDVFGWATQQDGRVVTDVLPIKGGEHTLVSSSSRQELGWHTEDAFSPYRADYVGLLSLRNPDGVATTLAGVPLDDLDERTLDVLFQERFLIRPDDSHLQVNNSTAQQGRVEFEGIAQAADRPEPVAILTGHRAAPHLRVDGDFSAPAEGDEEAAAALGTLRKLIDASLYELVLDQGDVAFIDNRRAVHGRRAFQPRYDGRDRWLKRINITRDLHRSRKAWAGDSRVLGQR
What is the function of this protein?
Involved in the biosynthesis of capreomycidine, an unusual amino acid used by non-ribosomal peptide synthases (NRPS) to make the tuberactinomycin class of peptide antibiotics such as viomycin and capreomycin.  Catalyzes the stereospecific hydroxylation of the C3 of (2S)-arginine to generate (3S)-hydroxy-(2S)-arginine.  Usually clavaminic acid synthase-like oxygenases catalyze the formation of threo diastereomers, however VioC produces the erythro diastereomer of beta-carbon-hydroxylated L-arginine.  It exerts a broad substrate specificity by accepting the analogs L-homoarginine and L-canavanine for the beta-carbon hydroxylation.
What are the official names of this protein?
Alpha-ketoglutarate-dependent L-arginine hydroxylase, Viomycin biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the clavaminate synthase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MQO_HELPH
Sequence: MSMEFDAVIIGGGVSGCATFYTLSEYSSLKRVAIVEKCSKLAQISSSAKANSQTIHDGSIETNYTPEKAKKVRLSAYKTRQYALNKGLQNEVIFETQKMAIGVGDEECEFMKKRYESFKEIFVGLEEFDKQKIKELEPNVILGANGIDRHENIIGHGYQKDWSTMNFAKLSENFVEEALKLKPNNQVFLNFKVKKIEKRNDTYAVISEDAEEVYAKFVLVNAGSYALPLAQSMGYGLDLGCLPVAGSFYFVPDLLRGKVYTVQNPKLPFAAVHGDPDAVIKGKTRIGPTALTMPKLERNKCWLKGISLELLKMDLNKDVFKIAFDLMSDKEIRNYVFKNMVFELPVIGKRKFLKDAQKIIPSLSLEDLEYAHGFGEVRPQVLDRTKRKLELGEKKICTHKGITFNMTPSPGATSCLQNALVDSQEIAAYLGESFELERFYKDLSPEELEN
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: AKA10_PIG
Sequence: RALRPDPGPAMSFFRRKARGREQEKTSDVPSGKASISVHSPQKSTKNHALLEAAGPSPVAISAISANMDSFSRSRTATLKKQPSHMEAAHFGDLGRSCLDYQAQETKSSLSKTLEQVLRDAVVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPTQKHETAAAPVTESLDQRLEEPSSAQLLLTQSEGIDLTDRTSNTQNHLLLSPECDGARALHPAAARTGARRASLEPQESCRLTVASRNSPSSPLKEVSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIAKICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYSSEYMEKEDAVNILQFWLAADNFQSQPAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSSLYYKYLNDLIHSVRGDEFLGASASLAAQGSGGPPDDPLPGASDPSASQSSVKKASVKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVKKSKGSMFSQAMKKWVQGNSDEAQEELAWKIAKMIVSDVMQQAQCAQPGETSAKL
What is the function of this protein?
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane.  Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA.  It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes.  With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).
What are the official names of this protein?
A-kinase anchor protein 10, mitochondrial, AKAP-10, Dual specificity A kinase-anchoring protein 2, D-AKAP-2, Protein kinase A-anchoring protein 10, PRKA10.
What are the subcellular locations of this protein?
Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.
Protein: GHRL_ANGJA
Sequence: MRQMKRTAYIILLVCVLALWMDSVQAGSSFLSPSQRPQGKDKKPPRVGRRDSDGILDLFMRPPLQDEDIRHITFNTPFEIGITMTEELFQQYGEVMQKIMQDLLMDTPAKE
What is the function of this protein?
Ligand for growth hormone secretagogue receptor type 1 (GHSR).  Induces the release of growth hormone from the pituitary.  Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion.  Involved in growth regulation.
What are the official names of this protein?
Ghrelin, Ghrelin-21.
What is the protein family that this protein belongs to?
Belongs to the motilin family.
What are the subcellular locations of this protein?
Secreted.
Protein: METXA_LEPIC
Sequence: MNETGSIGIIETKYAEFKELILNNGSVLSPVVIAYETYGTLSSSKNNAILICHALSGDAHAAGYHSGSDKKPGWWDDYIGPGKSFDTNQYFIICSNVIGGCKGSSGPLSIHPETSTPYGSRFPFVSIQDMVKAQKLLVESLGIEKLFCVAGGSMGGMQALEWSIAYPNSLSNCIVMASTAEHSAMQIAFNEVGRQAILSDPNWKNGLYDENSPRKGLALARMVGHITYLSDDKMREKFGRNPPRGNILSTDFAVGSYLIYQGESFVDRFDANSYIYVTKALDHYSLGKGKELTAALSNATCRFLVVSYSSDWLYPPAQSREIVKSLEAADKRVFYVELQSGEGHDSFLLKNPKQIEILKGFLENPN
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.