PharMolix/UniProtQA huggingface dataset:
Protein: MCM3_MOUSE
Sequence: MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQNKVRELISDNQYRLIVSVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGCYTSGTFRTVLIACNVKQMSKDIQPAFSADDIAKIKKFSKTRSKDVFEQLARSLAPSIHGHDYVKKAILCLLLGGVERELENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFTQDDQQDTRIYEKHDSLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPTLTQESAAYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKASEDESDLEDEEEKSQEDTEQKRKRRKTHAKDGESYDPYDFSEAETQMPQVHTPKTDDSQEKTDDSQETQDSQKVELSEPRLKAFKAALLEVFQEAHEQSVGMLHLTESINRNREEPFSSEEIQACLSRMQDDNQVMVSEGIVFLI
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.  Required for the entry in S phase and for cell division.
What are the official names of this protein?
DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: TPC10_DICDI
Sequence: MSNVSPNSMNLNGSTSSTASVNDSGGGGGGGNVTSPTLSSSSASSISNSNSSSSNNLKPSTQPLSSSSTLNTPTQFSLQHSSSSSSLNNTNIDIIEHITISYQDESSIWKYIEAELPNHLPLKNISWKTKTGHTKVVEKMPIEILQYNDERVKAHYDNQNLYKKPYLYLYLVHCDDPDTYKNVVRAKIKQWVTQMTERQQEWLIVYVSLGPKRFSELTSKLTRTVFDRIKNDFNVKRDRCCQLRFLDTNNTSSGNNKDKDNDNGGGSSGTGLSTSTKQQDDLWDDFLIKMKEGIISSAEQYLTTYEDEIRKMDAKRTTPGWSYQNFFFIKEGLALIYERAQLYEDALMQYFELEVLFGDPNNRSQFDQITDEVLQPNSIHCNGNILDTSFKNYRKLIYENKISLFDFKVYLFARQSKLLFLLQKPIEAATKSISFITSMSMIIKQYPNSFAPMFKESWIFSTSMELIKACQDSFDKIVNGAQQQQQQQQQQLQLQQQLQQQQQQQTINGSAQKVVKSISSTTPISKLFGAFGPFGSSSSNTPSSTSATTAANGKNTPMPSNSGIASLSAGGSTIIAGLSGSQSLNNLQSAQLSGALNTQHYIRTPSLNLTSDLSERLTEKQDRESLDFLVGDLLFSSAQRLEELAIIIGYLPVDDYNSEMFFQNVEEVIFKSVENKKIEVDSMTAFSYQPLQVSLQSSKQFTQLYFELLGQIEKLYIQSNRMRSISRLTFAIANLNFKLKEFQIAENLFKSISNLYSREHWSYIEYAVKTRLSYCQKQLGHLVDYVTTCVGLLAPGLLTNRFEKDHYLSEIIQISRKPELNIVQPMIPLFKCKVTFKETVYRYFETIKINVRIKSNLISPIRFNNGAVSFVKSGFGDKLVFQLNDFLVEPGVNNFQFTAVGTTKATFVKDSIWLKIDNLSFGYSLRNADTAIGGGGGGTNTTTTTLPGEIKVIDSESQITLESFANSPLLFYSIQYVGIKLHTHSDTIEAGVLTFTSPTGATIIPTSSVIIIQSDDKTCETSSRTINLINDKLPLSQIGYNQTLEFYLPLMAVNTDTCTHQIRIELQHQKQTKEKFSSSLVSSILFINPLTIDESVINVNNRLFLKTIIQCNSPNMIQFNSYSLEGCDSEYQSPEQQQLQQQLQQQQQLSLSSSSSSISSISSKSSQQPNLYYLVKDHNHSLAPNLNLYPGQLVSLIFEIKKYENESLSSSTSPSSATDSSNSNGNNNNNNNNNNHSKNDLKLKIKYTSKMPQQDLDRPLIRECKSLWRDQNEFSWPIKIELPTYLYQIDLSIQSRAYVGTIVLFEIEITNLKQQQQQQKESNNDNGNEKQQKQQQLQYHIVADSQIWMISGKSKHTFSFNSDTVGEKLKFSCGLIPISSGSLPIPKVTLVGINNSNISYPKTKNEKIFVYPSPQIYSCHQLQDNNNNNNNSINSQTSTNKT
What is the function of this protein?
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
What are the official names of this protein?
Trafficking protein particle complex subunit 10, Trafficking protein particle complex subunit TMEM1, Transport protein particle subunit TMEM1, TRAPP subunit TMEM1.
What is the protein family that this protein belongs to?
Belongs to the TMEM1 family.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network.
Protein: MRAZ_LEGPL
Sequence: MFRGINAITIDTKGRLAIPTRYRSALGAEDKIPLVVTIDTEETCLLLYTAAQWQIIEDNLQKLPSFNAAARRIQRLLIGHATDVEVDANGRVLLPTVLRNYAKLEKDVVMIGQGNKFEVWNKELWESKREQWLAEEASMTDGLPEEMKTFSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: GLNE_KLEP7
Sequence: MMPLSPQLQQHWQTVADRLPADFPVAELSPQARSVMAFSDFVEQSVIAQPGWLNELADSAPAAEEWRHYEAWLQERLQAVTDEAGLMRELRLFRRQMMVRIAWAQALSLVREEETLQQLSVLAETLIVAARDWLYAACCKEWGTPCNAEGQPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGATRGGRRELDNAQFFTRLGQRLIKALDQPTQDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDNDGAYASELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPALQQRALLPTLAAIDELHLLPEGDATLLRAAYLFLRRLENLLQSINDEQTQTLPQDELNRARLAWGMHTDDWETLSAQLANHMANVRRVFNELIGDDEAQSPDEQLAEYWRELWQDALEEDDASPALAHLNDADRRSVLALIADFRKELDRRTIGPRGRQVLDQLMPHLLSEICSRADAPLPLARITPLLTGIVTRTTYLELLSEFPGALKHLITLCAASPMVASQLARHPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQQLHIAAADIAGTLPVMKVSDHLTWLAEAILDAVVQQAWGQMVARYGLPTHLHDRQGRGFAVVGYGKLGGWELGYSSDLDLVFLHDCPAEVMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTTADAFADYQQNEAWTWEHQALVRARVVYGDPALQARFDAIRRDILTTPREGATLQTEVREMREKMRAHLGNKHPNRFDIKADAGGITDIEFITQYLVLRYASDKPKLTRWSDNVRILELLAQNDIMDEEEARALTHAYTTLRDALHHLALQELPGHVAPEAFSREREQVSASWQKWLMA
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: MBHS_RUBGE
Sequence: METFYEVMRRQGISRRSFLKYCSLTATSLGLAPSFVPQIAHAMETKPRTPVLWLHGLECTCCSESFIRSAHPLAKDAVLSMISLDYDDTLMAAAGHQAEAILDEIMAKYKGNYILAVEGNPPLNEDGMFCIQRQALPREAQAVAADCKAVIAWGSCASWGCVQAAKPNPTQATPIHKVITDKPIIKVPGCPPIAEVMTGVITYMLTFDRIPELDRQGRPKMFYSQRIHDKCYRRPHFDAGQFVESFDDENARKGFCLYKVGCKGPTTYNACSTVMWNEGTSFPIKAGHGCTGCSEDGFWDKGSFYDRLTNIHQFGIEASADKVGGTAAGVVGAAIAAHAAASVIKRLSHDPDAAARAESRS
What is the function of this protein?
This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions.
What are the official names of this protein?
Uptake hydrogenase small subunit, Hydrogenlyase, Membrane-bound hydrogenase small subunit.
What is the protein family that this protein belongs to?
Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NACA_DANRE
Sequence: MPGEATETVPVTEQEMQQPQAETGSGTESDSDESVPDLEEGDSAQTQTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVAGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNNNDIVNAIMELTM
What is the function of this protein?
May promote appropriate targeting of ribosome-nascent polypeptide complexes.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: PDEG_PLAYE
Sequence: MKHMFKNILFHKKGKHDKNDAIKKAFSLFSVPSNENERIIKFWPLKFKEKDEETLYIIKLCDNMYSKKYVILVSHLISLLLMYSVCLIVGNINDLFSVLKLTYILLHTFTAINIILILTLHATHYVEMFKSIKGEIFIFYIMMIFVIWCSWLFILFNNIKDLLPIVVNVNNFLYATYANNKINIVLGFFAYLPIFYLITIIPCRICYSCAFDILFFIMKVAIFSVYYLITMKSYILTDNIFMIISALVGSLFIFVIRYIIEIQRRLSFHNWNKQTKQIIKLKKTLKEEKQKLSTTNIEEIYNLINDSIGNYYNENKKQKETDWSIVNNLEKILNILKEDNLFSPDLKTINKKNYNHIYGYIMDLKKQKEIINDKIGSKEEPEAESESECVDESKEGSQIESIFESISDVKQKKKSDLAYTSSYEEKENEILKYDFNMNMDKENISIDIWNTKFLDRKSPNYDAFIKIGYILLNKYYISNQNISVKILYSLLYEMKKGYNDVPYHNSIHAAMVTKHCSILITSLDTVNILKDNEMAAFLISALGHDIGHFGRTNMFLKNCSNFLRIIYNDKSILENYHCSYLFNILSKEEHNIFKKEDLKTLTNLRQLIIEVILATDMSKHIKILAQFRIKSIKIKSYIEKNIILCLKMIIKAADLSHNCVDWSEHYLWVKRLVNEFYSEGDDLLERGFELNPLFDRKAHNNFIQIQRTFLRELVLPLISSLKTLDTSTITQLMLSHVKRNYSKWTKIEKDETKKEKYLNELLTDVPNSWKIVYAPNLNIYKL
What is the function of this protein?
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (Probable).  Probably by regulating cGMP levels, required for sporozoite motility and invasion of the mosquito salivary glands (PubMed:25784701).
What are the official names of this protein?
cGMP-specific 3',5'-cyclic phosphodiesterase gamma.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Intracellular localization in blood stage forms and in sporozoites (PubMed:25784701). Partially, localizes to the endoplasmic reticulum in blood stage forms (PubMed:25784701).
Protein: THS3_ARAHY
Sequence: MVSVSGIRKVQRAEGPATVLAIGTANPPNCIDQSTYADYYFRVTNSEHMTDLKKKFQRICERTQIKNRHMYLTEEILKENPNMCAYKAPSLDAREDMMIREVPRVGKEAATKAIKEWGQPMSKITHLIFCTTSGVALPGVDYELIVLLGLDPCVKRYMMYHQGCFAGGTVLRLAKDLAENNKDARVLIVCSENTAVTFRGPSETDMDSLVGQALFADGAAAIIIGSDPVPEVEKPIFELVSTDQKLVPGSHGAIGGLLREVGLTFYLNKSVPDIISQNINDALNKAFDPLGISDYNSIFWIAHPGGRAILDQVEQKVNLKPEKMKATRDVLSNYGNMSSACVFFIMDLMRKRSLEEGLKTTGEGLDWGVLFGFGPGLTIETVVLRSVAI
What are the official names of this protein?
Stilbene synthase 3, Resveratrol synthase 3, RS3, Trihydroxystilbene synthase 3.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_PSEF5
Sequence: MQAYQRDFIRFAIDRGVLRFGEFTLKSGRTSPYFFNAGLFNSGSALAQLGRFYAAAIVESGIPFDVLFGPAYKGIPLAAATAVALAEHHQRDLPWCFNRKEAKAHGEGGSLVGAPLTGDVLIIDDVITAGTAIREVMQIIESQDGAKAAGVLIALNRQERGNGELSAIQEVERDFGIPVVSIVSLTQVLQFLADDPALKQHLPAVEAYRAQYGI
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: RAA5A_ARATH
Sequence: MAFYSEDDKSEDYLFKIVLIGDSAVGKSNLLARFARDEFYPNSKSTIGVEFQTQKMDINGKEIKAQIWDTAGQERFRAVTSAYYRGAVGALLVYDISRRQTFHSIGRWLNELHTHSDMNVVTILVGNKSDLKDLREVSTAEGKALAEAQGLFFMETSALDSSNVAAAFETVVKEIYNILSRKVMSSQELNKQDPASLSNGKKVVIPSDGQGEFKKGGCCSS
What is the function of this protein?
Intracellular vesicle trafficking and protein transport.
What are the official names of this protein?
Ras-related protein RABA5a, AtRABA5a.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: GPI12_SCHPO
Sequence: MIWFWSTLLVTAIAVLSTANESSSGQEKLAVESILFVFAHPDDESMFFGPTIDYLGNQHSTRVHVLCLSNGNADGLGSVREKELVVAASKYQIDKTNVHVVSDPQLQDGMQAKWDPTDVAKHISQIIERYNIKTLITFDNKGISGHPNHIACYEGAMKIVKATPQVQVFVLESVNIFRKYISYLDTIPTLVQSQAGRNDTIIIHADRKSTQRIRDAMVRGHKSQMVWFRYGWIYLSKYMSNNVLKRAT
What is the function of this protein?
Involved in the second step of GPI biosynthesis.  De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity).
What are the official names of this protein?
Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase.
What is the protein family that this protein belongs to?
Belongs to the PIGL family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: PSD_SOLUE
Sequence: MKIVSTGIYYALALCAAAALVAWLAGPLFAIPLILVALFCLYFFRDPDREIPAGPVAVSPADGKVVAVKPEGGLSRLSIFLNVFDVHVNRTPIAGTIQKVQYKEGQFLVASREECSTDNEQNIVTVAGDGTTVIFKQIAGLIARRIVFTKRPGDHVALGERIGLIKFGSRMDVLFGPEWEITVRPGQRVSAGSSIIARRLDRKS
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ARGB_CAMC5
Sequence: MQNSLQVAQVIISALPYIQKFRNKIFVVKYGGSAQIDDTLKNDFVRDIALLQLVGCKVVVVHGGGKKINSYLDRLHIKSEFVDGLRVTDKEAMEIVEMVLSGNINKEITALLNKNGARAIGVSGKDANLLKARILNNGKYGFVGEIERVNTYVLNGLLENGLIPVVAPVATDDEANSYNINADLCASKIASALKAERVIFLTDTRGILDKDGNLISKLNEAHITALKEDGTINGGMIPKVDAALECVKNGVANAHILDGRLPHSLLLELFTDDGIGTMIKG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H32_TETRO
Sequence: MARTKQTARKSTGAKAPRKQLASKAARKSAPATGGIKKPHR
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.2.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ATP6_BRUC2
Sequence: MANDPIHQFQVSRWIPIDVGGVDLSFTNVSAFMVATVVLASGFLYLTSSGRGLIPTRLQSVSEMAYEFVATSLRDSAGSKGMKFFPFVFSLFMFVLVANFIGLFPYFYTVTSQIIVTFALSLLVIGTVIFYGFFKHGFGFLKLFVPSGVPGIIVPLVVLIEIISFLSRPISLSVRLFANMLAGHITLKVFAGFVVSLSSLGALGIGGAVLPLLMTVAITALEFLVAFLQAYVFTVLTCMYINDAVHPGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEUD1_DEIRA
Sequence: MPRIWKFGDSVNTDDILPGKFAPFMAGEDVFQTFAFHYVRPEFAAQVQPGDVLIGGRNWGLGSSREYAPQALKKLHIGGIVAPSFARIHYRNLLNLGIPAFEYDLTELLEDGDEVTLDAQTGLLTYADGTVQLPPPPEFLREALKEGSILEFFKKHGRFPGEEPGAEASTETASAAE
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit 1, Alpha-IPM isomerase 1, IPMI 1, Isopropylmalate isomerase 1.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: UGPA_BOVIN
Sequence: MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTAPSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSIQPYEKIKARGLPDNVSSVLNKLVVVKLNGGLGTSMGCKGPKSLIGVRNENTFLDLTVQQIEHLNKTYDTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPRINKESLLPVAKNVSYSGENTEAWYPPGHGDIYASFYNSGLLDTFIGEGKEYIFVSNIDNLGATVDLYILNHLMNPPNGKPCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKFKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNPKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVQDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLKGTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDH
What is the function of this protein?
UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.
What are the official names of this protein?
UTP--glucose-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, UGPase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_YERPN
Sequence: MAKEDNIEMQGTVLDTLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVELTPYDLSKGRIVFRSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_SALTI
Sequence: MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVTSIIGNGVVLSPSALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEYGATTGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPLAADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRTETMILRDPFDA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMO3_CAVPO
Sequence: MVKKVAIIGAGVSGLASIRSCLEEGLEPICFERSNDIGGLWKFSDHAEEGRASIYKSVFTNSSKEMMCFPDVPFPDDFPNFMCHRKLQEYIVAFAKQKSLLKYIQFETLVTSVTKRPDFSITGQWDITTEKHGKKQSAVFDAVMVCSGHHVYPNIPKESFPGLKDFKGKCFHSRDYKEPGIWKGKRVLVIGLGNSGCDIAAELSHTAEQVMISSRSGSWVMSRVWDDGYPWDMLFVTRFQSFLKNKLPTAISDWWYVKQMNARFKHENYGLMPLNGTLRKEPVFNDELPARILCGTVSIKPNVKKFTETAAIFEDGTKFEGIDCVIFATGYTYAYPFLDESIIKSRNNETTLYKGIFPPHLEKSTFAVIGLVQSLGAAIPTTDLQARWATQVIKGTCTLPSVKVMMDDIDGKVGKNKKWFGQSETLQTDYVVYMDEIASFIGAKPNILWLFLTDPVLAVEVFFGPCSPYQFRLEGPGKWSGARNAILTQWDRTLKPTSTRIVGDLQKPYVFFHLFKLFTISILFIALFLMLI
What is the function of this protein?
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:2369122).  Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite.  TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.  By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (By similarity).
What are the official names of this protein?
Flavin-containing monooxygenase 3, Dimethylaniline monooxygenase [N-oxide-forming] 3, Dimethylaniline oxidase 1, Hepatic flavin-containing monooxygenase 1, FMO 1, Trimethylamine monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
Protein: NDK_BURP6
Sequence: MALERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVAARMAHLSRADAEKFYAVHAERPFFKDLVDFMISGPVMIQVLEGEDAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETARAEVAFFFPEMNVYSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXK_RHOPT
Sequence: MREPGFWHRPPSLVSRLLLPIAAIYGNIAAARMQKAGTTVGVPVLCVGNYHMGGAGKTPTTLALVALLREFGETPVVLSRGYGGRLQGPVQVDPSRHSAADIGDEPLMMARRLAVVVARDRTDGAALACALGATVILMDDGFQNPALTKDASLIVVDSHRSIGNGSVFPAGPLRAPLPLQVARTDALVVVGDGAAADGLAQQITTKGGVVLRARLVPEPASVEALRGRRVLAFAGIGDPARFVATLRGSGVEVVEQRAFADHHPFTAEELAELAAAAKRDGLTLVTTEKDLARIGRAQQALGVEIVPFAVTLAFGDEAKLRLFLLDRLNGARAAKLAGRR
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: EZH1_PONAB
Sequence: MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVCGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFLDYRYSQADALKYVGIERETDVL
What is the function of this protein?
Polycomb group (PcG) protein.  Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene.  Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.  Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity.  Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
What are the official names of this protein?
Histone-lysine N-methyltransferase EZH1, Enhancer of zeste homolog 1.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.