PharMolix/UniProtQA huggingface dataset:
Protein: NEPU1_THEVU
Sequence: MIKLLKPMSLSILLVFILSFSFPFPTAKAAANDNNVEWNGLFHDQGPLFDNAPEPTSTQSVTLKLRTFKGDITSANIKYWDTADNAFHWVPMVWDSNDPTGTFDYWKGTIPASPSIKYYRFQINDGTSTAWYNGNGPSSTEPNADDFYIIPNFKTPDWLKNGVMYQIFPDRFYNGDSSNDVQTGSYTYNGTPTEKKAWGSSVYADPGYDNSLVFFGGDLAGIDQKLGYIKKTLGANILYLNPIFKAPTNHKYDTQDYMAVDPAFGDNSTLQTLINDIHSTANGPKGYLILDGVFNHTGDSHPWFDKYNNFSSQGAYESQSSPWYNYYTFYTWPDSYASFLGFNSLPKLNYGNSGSAVRGVIYNNSNSVAKTYLNPPYSVDGWRLDAAQYVDANGNNGSDVTNHQIWSEFRNAVKGVNSNAAIIGEYWGNANPWTAQGNQWDAATNFDGFTQPVSEWITGKDYQNNSASISTTQFDSWLRGTRANYPTNVQQSMMNFLSNHDITRFATRSGGDLWKTYLALIFQMTYVGTPTIYYGDEYGMQGGADPDNRRSFDWSQATPSNSAVALTQKLITIRNQYPALRTGSFMTLITDDTNKIYSYGRFDNVNRIAVVLNNDSVSHTVNVPVWQLSMPNGSTVTDKITGHSYTVQNGMVTVAVDGHYGAVLAQ
What is the function of this protein?
Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose.  Also hydrolyzes cyclodextrins.
What are the official names of this protein?
Neopullulanase 1, Alpha-amylase I, TVA I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA_CERS1
Sequence: MLGLGTLARKIFGTPNDRKVKSVRSLVARINDLEPEFQALSDEGIKQKTAEFQRRVQEGGESLDDLLPEAFANCREGARRALGLRAFDVQLMGGIFLHQGNIAEMKTGEGKTLVATFPAYLNALAGKGVHVVTVNDYLAKRDAEWMGKVYAQLGLATGVVYPFQSDEEKKAAYAADITYATNNELGFDYLRDNMKASKEEMRQRGHFFAIVDEVDSILIDEARTPLIISGPSQDRSDLYTKVDKLIPELVEEHYKLDEKTRNVTFTEEGNEFLEKRLLETGLLPEGQSLYDPESTTIVHHVNQGLRAHKLFNRDQQYIVRDDEIMLIDEFTGRMMRGRRLSDGLHQAIEAKEGVSIQPENVTLASVTFQNYFRLYEKLGGMTGTAATEAEEFMEIYGLGVVEVPTNRPVARADEHDAVYRTAREKHDGIVASIKDAHERGQPILVGTTSIDKSEALSDLLKAAGIPHNVLNARQHEQEAQIVADAGKLGAVTIATNMAGRGTDIQLGGNVEMKVMQALAADPTAHPDEVRARIEAEHAEEKERVKEAGGLFVLGTERHESRRIDNQLRGRSGRQGDPGRSAFFLSLEDDLMRIFGSDRLDKVLSTLGMKEGEAIVHPWVNKSLEKAQAKVEARNFDIRKQLLKFDDVMNDQRKAIFSQRLEIMETEDLSEIAQDMRYQVIDDLIDQHMPPRSYADQWDIEGMHRAVQDKLGLDAPLAKWAQEEGVDLDVVRERLCEASDRQMTEKAEAFGPETMRSIEKQILLQTIDAKWREHLLTLEHLRSVVGFRGYAQRDPLSEYKTEAFALFESMLNSLRQDVTQKLAQVRPLSEEEQQAMMRQFLDQQRAAAAAEAPVAPAPQPAAAAPQPTPELVGAEAGEPDPAAWGNVARNDPCPCGSGLKYKHCHGRLD
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: MURQ_TRIV2
Sequence: MANLQERGHLLTEQVNPLSQNLDQLSSLELVELFNSEDRKTIEAVAAAKVQIATAIEQTADRLRQGGRLFYVGAGTSGRLGVLDAAECPPTFCTPPELVQGIIAGGAGALVRSSEDLEDRAEDGDAAIAQRHITQLDVVVGITAGGTTPFVQGAINSARQRGALTIFIACVPAEQVSFTADIDIRLLTGPEILAGSTRLKAGTVTKLTLNILSTGVMVKLGKVYGNRMVDVAVTNQKLRDRALRILEDLTGLSREAAGFLLERSGKWVKLALVMHWTGLDKDAGDRLLSAHQGNLREAVASYKNQGN
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: AROC_SULIY
Sequence: MPGNSFGKLFRVTTFGESHGPAVGVVIDGVPAGLPLTVEDIKFELEFRRPGRLYVSGRREKDEPEILSGIFNNRTTGSPIAVIVRNTDVISSFYEEIRYKPRPGHADLPFIMKYGYENWDYRGGGRASARETVGRVIAGAVAKKLLMLADTWIAGHLRSLGPEELNEEVTFEEVLCSKYSPVRASKKVLEEKYEALIKKATQEGDSYGGIAEVITKNPPIGLGEPVFDKMKAELAKAIMSIPAVTGFEYGLGFMVSKMKGSEANDEIIRKDNKIGWKYNYAGGILGGLTNGEDLIVRCAFKPTSSIRKPQKTIDLRNLEETYISVIGRHDPAVAIRGVTVVESMVALTLVDHAMRAGVIPLVKLTEEQGNIVQQRWERYVRSCKPMEESQL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: TYSY_MESM1
Sequence: MEQYLSLLKEILEKGQKKEDRTNTGTISYFGTQRRYDLSKGFPLVTTKKVHLKSIIFELLWFIKGDTNIKYLVDNGVNIWNEWPYETFKKSKDFNGESLADFVLKIKSDTLFAKKYGELGPVYGKQWRNFNGTDQLFDAIETIKKNPDSRRIIVSAWAANEISKMALPPCHAFFQFYVNNNKLSLQLYQRSGDTFLGVPFNIASYSILLAMVAQITNYEVGEFIHTIGDTHIYLNHLEQVEEQLSRKPLKLPKLVLNKKIKNIDDFKYEDIEIIDYESHPAIKAKVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Protein: PRS41_HUMAN
Sequence: MGARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHSTPRPNPSQLLLLLALLWAP
What are the official names of this protein?
Serine protease 41, Testis serine protease 1, TESSP-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized in the plasma membrane of spermatogonia. Localized in intracellular compartment in spermatocytes, probably in the Golgi apparatus (By similarity).
Protein: HXA7_HUMAN
Sequence: MSSSYYVNALFSKYTAGASLFQNAEPTSCSFAPNSQRSGYGAGAGAFASTVPGLYNVNSPLYQSPFASGYGLGADAYGNLPCASYDQNIPGLCSDLAKGACDKTDEGALHGAAEANFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKDEGPTAAAAPEGAVPSAAATAAADKADEEDDDEEEEDEEE
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A7, Homeobox protein Hox 1.1, Homeobox protein Hox-1A.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GS1L2_HUMAN
Sequence: MDRAKQQQALLLLPVCLALTFSLTAVVSSHWCEGTRRVVKPLCQDQPGGQHCIHFKRDNSSNGRMDNNSQAVLYIWELGDDKFIQRGFHVGLWQSCEESLNGEDEKCRSFRSVVPAEEQGVLWLSIGGEVLDIVLILTSAILLGSRVSCRSPGFHWLRVDALVAIFMVLAGLLGMVAHMMYTTIFQITVNLGPEDWKPQTWDYGWSYCLAWGSFALCLAVSVSAMSRFTAARLEFTEKQQAQNGSRHSQHSFLEPEASESIWKTGAAPCPAEQAFRNVSGHLPPGAPGKVSIC
What are the official names of this protein?
Germ cell-specific gene 1-like protein 2, GSG1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the GSG1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NUDC_ECOL5
Sequence: MDRIIEKLDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLVQLQRRHDMGSVRQVIDLDVGLFQLAGRGVQLAEFYRSHKYCGYCGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGEIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCRAEYE
What is the function of this protein?
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.  The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing.  Has preference for mRNAs with a 5'-end purine.  Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
What are the official names of this protein?
NAD-capped RNA hydrolase NudC, DeNADding enzyme NudC, NADH pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudC subfamily.
Protein: RL33_BUCAT
Sequence: MAKKAREKIKMISSAGTGHYYTTTKNKRNTPDKLKLKKYDPVIRKHILYNEGKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: TNR6B_MOUSE
Sequence: MQTNEGEVEEESSSQVEQEDFVMEGHGKTPPPGEESKQEKEQEREEQLMEDKKRKKEDKKKKEATQKVTEQKTKVPEVTKPSLSQPTAASPIGSSPSPPVNGGNNAKRVAVPNGQPPSAARYMPREVPPRFRCQQDHKVLLKRGQPPPPSCMLLGGGAGPPPCTAPGANPNNNAQVTGALLQSESGTAPESTLGGAAASNYANSTWGPGASSNSGASPNPIHIWDKVIVDGSDMEEWPCIASKDTESSSENTTDNNSASNPGSEKSSLPGSTTSNKGKGSQCQAASSGNECNLGVWKSDPKAKSVQPPNSTSDSNNGLGNWRSTSGQDRIGPGSGFSNFNPNSNPSAWPALVQEGTSRKGALETESSSSSAQVSTVGQASREQQSKMENAGVNFVVSGREQAQIHNTDGPKNGNTNSLNLSSPNPMENKGMPFGMGLGNTSRSTDAPSQSTGDRKTGSVGSWGAARGPSGTDTVSGQSNSGNNGNNGKDREDSWKGASVPKPTGSKSDSWDNNNRSTGGSWNFGPQDNNDNKWGEGNKMTSGVSQGEWKQPTGSDELKIGEWSGPNQPNSSTGAWDNQKGHPLPENQGNAQAPCWGRSSSSAGSEVGGQSTGSNHKAGSSDSHNSGRRSYRPTHPDCQAVLQTLLSRTDLDPRVLSNTGWGQTQIKQDTVWDIEEVPRPEGKSDKGTEGWESAATQTKNSGGWGDAPSQSNQMKSGWGELSASTEWKDPKSTGGWNDYKNNNSSNWGGGRADEKTPSSWNESSCKDQGWGGGRQPNQGWTSGKNGWGEEVDQVKNNNWESSANKPVSGWGEGGQNEIGTWGNGGNTNLASKGGWEDCKRSPAWNETGRQPNSWNKQHQQQQQPPPPQPEASGSWGGPPPPPQGNVRPSNSNWSSGPQPTTPKDDEPSGWEEPSPQSISRKMDIDDGTSAWGDPNSYNYKNVNLWDKNSQGGPAPREPNLPTPMTGKSASVWSKSTPPAPDNGTSAWGEPNESSPGWGEMDDAGASTTGWGNTPANAPNAMKPNSKSMQDGWGESDGPVTGARHPSWEEEDDGGVWNTAGSQGSTSSHNSASWGQGGKKQMKCSLKGGNNDSWMNPLAKQFSNMGLLSQTEDNPSSKMDLSVDKKFDVDKRTMNLGDFNDIMRKDRPGFRPPNSKDLGTTDSGPYFEKGGSHGLFGNSTAQSRGLHTPVQPLSSSPGLRAQVPPQFISPQVSASMLKQFPNSGLNPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQQQQRQPSMKHSPSHPVGPKPHLDNMVPNALNVGLPDLPTKGPIPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEATMHKNGAIVAPGKTRGGSPYNQFDIIPGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGTTTSPIVDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLTRPPPGLTNPKPASPWSSTAPRSVRGWGTQDSRIASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFATEDEVSRFLAQAQPPTPAATPSAPATGWQSLETSQNQADPVGPALNLFGGSTGLGQWSSSAGGSSGADLAGTSLWGPPNYSSSLWGVPTVEDPHRMGSPAPLLPGDLLGGGSDSI
What is the function of this protein?
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs).  Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins.  As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
What are the official names of this protein?
Trinucleotide repeat-containing gene 6B protein.
What is the protein family that this protein belongs to?
Belongs to the GW182 family.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs).
Protein: YHBP_SALTI
Sequence: MDTLTAIGRWLAKQHVVTWCVHHEGELWCANAFYLFDAQNVALYLLTDDKTRHAQMSGACAPVAGTVNGQPKTVARIRGVQFKGEIRRLEGQESDAARKAYLRRFPVARVLPAPVWEIRLDEIKFTDNTLGFGKKLHWLRDSRAQQA
What are the official names of this protein?
UPF0306 protein YhbP.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: THIO_GRIPA
Sequence: MSISQVIDTSFHEEVINSRQPVLVDFWAPWCGPCRMIASTIDEIAHDYKDKLKVVKVNTDQNPTIATEYGIRSIPTVMIFINGKKVDTVVGAVPKLTLLNTLQKHLKST
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRUB_ECO57
Sequence: MSRPRRRGRDINGVLLLDKPQGMSSNDALQKVKRIYNANRAGHTGALDPLATGMLPICLGEATKFSQYLLDSDKRYRVIARLGQRTDTSDADGQIVEERPVTFSAEQLAAALDTFRGDIEQIPSMYSALKYQGKKLYEYARQGIEVPREARPITVYELLFIRHEGNELELEIHCSKGTYIRTIIDDLGEKLGCGAHVIYLRRLAVSKYPVERMVTLEHLRELVEQAEQQDIPAAELLDPLLMPMDSPASDYPVVNLPLTSSVYFKNGNPVRTSGAPLEGLVRVTEGENGKFIGMGEIDDEGRVAPRRLVVEYPA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: PDC_NEUCR
Sequence: MVAQQQGKFTVGDYLAERLAQVGVRHHFVVPGDYNLILLDKLQAHPDLKEVGCANELNCSLAAEGYARANGISACVVTYSVGALSAFNGTGSAYAENLPLVLISGSPNTNDPSQYHILHHTLGHPDYTYQYEMAKKITCCAVAIPRAIDAPRLIDRALRAAILARKPCYIEIPTNLAGATCVRPGPISAITDPITSDKSALEAAAKCAAEYLDGKLKPVILVGPKAGRAGSEKELIEFAEAMGCAVALQPAAKGMFPEDHKQFVGIFWGQVSSDAADAMVHWADAMICVGAVFNDYSTVGWTAVPNIPLMTVDMDHVTFPGAHFSRVRMCEFLSHLATQVTFNDSTMIEYKRLKPDPPHVHTAEREEPLSRKEISRQVQEMLTDKTSLFVDTGDSWFNGIQLKLPPGAKFEIEMQWGHIGWSIPAAFGYALRHPDRHTIVLVGDGSFQVTAQEVSQMVRFKVPITIMLINNRGYTIEVEIHDGSYNKIKNWDYAMLVEAFNSTDGHAKGLLANTAGELADAIKVAESHKEGPTLIECTIDQDDCSKELITWGHYVAAANARPPRNMSVQE
What are the official names of this protein?
Pyruvate decarboxylase, 8-10 nm cytoplasmic filament-associated protein, P59NC.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Cytoplasmic filaments.
Protein: PAND_CLOK1
Sequence: MQLNMLKSKIHRATVTEANLNYVGSITIDRELMESAHIIEYEKIQVVDIDNGNRLETYVIAGEKGSKVICLNGAAARHVQPGDKVILMTYCQMDEEEAKIHKPIVIFLDENNSIFQITDYEKHGQVK
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMTA_ECODH
Sequence: MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSDRKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.  Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.
What are the official names of this protein?
Endo-type membrane-bound lytic murein transglycosylase A, Peptidoglycan lytic endotransglycosylase.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: CUTA_SHIB3
Sequence: MLDEKSSNTASVVVLCTAPDEATAQDLAAKVLAEKLAACATLIPGATSLYYWEGKLEQEYEVQMILKTTVSHQQALLECLKSHHPYQTPELLVLPVTHGDTDYLSWLNASLR
What is the function of this protein?
Involved in resistance toward heavy metals.
What are the official names of this protein?
Divalent-cation tolerance protein CutA.
What is the protein family that this protein belongs to?
Belongs to the CutA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUE1_DEBHA
Sequence: MDNSTIVFIAVLGVAFIFLRWLIAPIPPQLPNELNEALANSVNNSNRPNNSNNSNSATNSNANRRGRREPSDDMIEVVQTIAPQLTRGQIRMDLERSGSVEVTMERYMETGSLPFPPGESAATQSYQSDISEHSQATKKEPENLIDKYDLKSKIKGDEGEGIENIDENKWGSSKEERSSLLNKKREEMILQARKRLASQLQNEVAL
What is the function of this protein?
Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway.  Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system.  Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).
What are the official names of this protein?
Coupling of ubiquitin conjugation to ER degradation protein 1.
What is the protein family that this protein belongs to?
Belongs to the CUE1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RAVA_SALNS
Sequence: MAHPHLLAERISRLSSALEKGLYERSHAIRLCLLAALSGESVFLLGPPGIAKSLIARRLKFAFQRARAFEYLMTRFSTPEEVFGPLSIQALKDEGRYERLTTGYLPEAEIVFLDEIWKAGPAILNTLLTAINERHFRNGAFEEKIPMRLLVAASNELPEADSSLEALYDRMLIRLWLDKVQDKANFRSMLVSQQDESDNPVPASLQVSDEEYQQWQKDIGAISLPDPVFELIFTLRQQLDNLPNAPYVSDRRWKKAIRLLQASAFFSGRDAVAPIDLILLKDCLWYDAQSLNLMQQQLEILMTGHAWQQQAMLTRLGGIVQRRLQLQQQQSDKTAFTVIKEGGMFSRRPHYTLPPEVSASTLTLLLQKPLKLHDMEVIHITFDRSALELWLTKGGEIRGKLNGIGFAQTLNMEVDNAQHLVVRDISLQGTRLALPGTAEDSMPAEIKQQLETLENDWRQQHTRFSEQQHCLFIHSDWLGRIEASLQDVGEQIRQAKQC
What is the function of this protein?
Functions as an ATPase.  May play a role in metal insertion (metal-chelatase) or as a chaperone.
What are the official names of this protein?
ATPase RavA, Regulatory ATPase variant A.
What is the protein family that this protein belongs to?
Belongs to the RavA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTPRC_HUMAN
Sequence: MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
What is the function of this protein?
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
What are the official names of this protein?
Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Protein: UB2E2_HUMAN
Sequence: MSTEAQRVDDSPSTSGGSSDGDQRESVQQEPEREQVQPKKKEGKISSKTAAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQWTKRYAT
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.  Catalyzes the ISGylation of influenza A virus NS1 protein.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 E2, E2 ubiquitin-conjugating enzyme E2, UbcH8, Ubiquitin carrier protein E2, Ubiquitin-protein ligase E2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: TOP3_STAHJ
Sequence: MKSLILAEKPSVARDIAEAMNIKGKRNGYIENEKYVVTWALGHLVTNAQPEHYDKAYKEWKLEDLPIIPKRMQTVVIGKTSKQFKTVKSLILDKKVKEVIIATDAGREGELVARLILDKVHNKKPIKRLWISSVTKKAIQEGFKKLKDGREFQHLYEAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVNARQQEINHFKAKKYYTLSTEIGGLTFQLSTNKQHMTMEDATQIANEIKHVEGNVDSVEKKVKKSHPKPLYNLTDLQQEAYQRYKMGPKETLNTIQNLYERHKVLTYPRTDSNYLTDDMVDTIKERLYALLATDYKSQVKSLLGQSYSSKMRIFKNHKVSDHHAIIPTEVRPDMQSLSNRESKIYMMVAERFLESLMAPHEYEAVRVNVTVGQHIFAFNEKVTRQLGYKALKMNNDNVVKKVAFQKGEKYHLQSLKVNEHETTPPDYFNEGSLLKAMENPQNYIQLKEKKHANTLRQTGGIGTVATRADIIEKLFNLNAIESRDGKIKVTSKGKQILDLAPQELTSPLLTAEWEEKLLLIEKGRYNSRHFIDEMKAFTQSIVNTIKNSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPTCKTKKNVQRKTNARCPNCKKKMTLFGRGKDAVYRCVCGHTETQEQMDKRFKNKSSGKVSKKEMKKYMNNEDSLENNPFKDALKNLKL
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 3, DNA topoisomerase III.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: GUAA_STRP6
Sequence: MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELREINPIGIVLSGGPNSVYADNAFGIDPEIFELGIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSNDCPYAAIENTEKNLYGIQFHPEVRHSVYGNDILKNFAISICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSVVGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVEDPEKKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPGPGLAIRVMGPITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFAQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.