Protein: ECDA_ASPRU
Sequence: MHRTNEMERKRVFTEICAEALKVEIDDLDETRSWVALGGDSMATIRLIARCEERGMRAKTADVIRCASITELFETIQYLQPSESIDREEVKPEDADAAPFSLWPEYHNATTTEEKQKLLNEVARHCNSTPNDIEDVYPSTPLQEGLMAITSRSPAAYVDRRAFTLPPTVDIARFRAALEALTARTHILRTRIIIDPLSGRSLQVVTRNEVVWREAMTLNDYLEDDRQEGIALGQPLSRCGLIQDKGSDGVEETVFVWTVHHSIYDGWSALQLYRQLAAIYNSEQLSPVVPYTRFVRYLQQQDPDSATQYWRDQLQGEDIMVDWPTLPTATYQPRPRTQFQANILLPDVSGSGLVMMSAVLRGAWALVMAQYSGYSDVIFGVTLSGRNAPVPQVADITAPLITTVPVRIRVDQKLTVAEFLDRIQTQATEMIEYEHTGLQQIMTFLPEYASALDFRNLLIIQPAVERDAYRAFPGISPINIPVEDFDSYGLNVECTLGREQIDIQLNYDEGVITTAALTNVMEQFSTLVRKMCRPDAQATSINEILTLPAQDAEQIKKWNADVPSPVHRCIHDLVQDQVRSQPAAIAVDAWDGRFTYAELASQSMRLAQHLTISHGVGPEQTIGLCMDKSRWAVVAMLAILYAGGAVLPLSGSHPLPRLQGIVEDANTRVILVDASQAARLVGMGRPLVIVDSTIVENLSPAQNEMRSGVTPSNMAWVVYTSGSTGMPKGVVLEHQSLCTSLTAHAKAIGITEHTRTLQFAAYTFDVSIMDTFSTLQAGGCVCVPSEEERLNRLAEAAARLEVNYAELTSTVTEMLSPSQVPSLTTLLLSGEPLKPAVLSIWAKHARVFNSYGPTECSITASNSRQLFHPDEARNIGAPMESLFWVVQSDNHQALCPIGTPGELLIEGPLLARGYLNDETTTNDSFITEPRFPEQIGLERTGRRMYRTGDLVQQNRDGSLLYVGRCGGQQVKIRGQRVDVSEVEHQITQRLPGVKTVAVELVGQGSQLSLMAVIEFAGGTSVTAAPVFEALREQLLHALPQYMVPTLYMPTDQMPINASGKLDRRGLRAQLQALTIAELQEYALNAGPKSAPSTAIEHKLQVLWAETLKVDPACIGREDSFVLLGGDSIAAMRMASLPAAQELHLSVADIFQHARLSDLARELEGRNLNENMQEADPAPFALWDTKQNQRAQRVAILAAQCGVTAGEVEDIIPCTAMQEGLMALTTHQPTAYVGRQVYRLAASIDTQRFQEAWKTLVYHTPILRTRLAVDEASDPQTGGLVQIVVGDGLTWKYSTDLDEYLACDEAEGMALGQPLVRLALVQQKEERFFIFTGHHSVYDGWSASLMFQRLAEIYLHNRIHSSPVPYSRFIRHLLKQDPVSTAGYWSTQLEGEAVVDWPPLPRADYQPRPMHRATHTITLPDNAKISTRGLSKLPHTLRAAWALVMATYAGGQGNRVVFGATVSGRNAPIRGITEMVGPTITTVPVAVQLDTQQTVSQFLEAVQKQAADMIPFEQTGLQIIRKLVPASCHATLELRNLFLVQPLPDGEETDLPGLASLPVTLEGFDTYGLTVQCSLGPDAVTVEMRYDENVIASARVKRIMNCFDHVVNQLYSKRNGAVPLGDLSLLSADDSTTIARWNQTSPERIERCIHHLIEEQITARPDSQAICAWDGDLTYAELNTQATQLSWYLRGLKVDAERMVGICMDKSKFAGVAMLAVLQAGGVVVPLGVNHPPSRNEGIVEDTAIDIILVDEQQRDRLSTMPNVQLVVIEQSLLDTLTIQPIERELPVNVTPNNAAWVIYTSGSTGKPKGVVLQHRALCSSIRAHGARFKMGPHTRMLQFAAHTFDACIQDYFTTLAFGGVVCVPSEHERMSDLSTAVRKLGVTFATLTSTVARLIDPNDVSAMQQLALVGEPVKADVVKRWLDHVTVLNAYGPSECSIHSTCSEPLTDPKQSAIIGTGMGSRVWVADVRDYNRLCPIGVPGELLIEGPILAREYLNDPQKTEKAFITNPAFLEELGISCNSNEGRMYRTGDLVRLDEHGSLTHLGRRDTQIKIRGQRVEVGEIEYQITQQLAGVRSAAVELLEDAGKVRLTVALDFALDSDLRRGPASELGVLLPSPALTTGLQRLRGSLFQVLPIYMVPTAFLPIMDMPLNASGKLDRRAVRALLEKVSFEEQRQYLAVSASESTVTPSTPTESQLRAVWADMLQLPVTQVNIHDNFFQLGGDSVVAMRMVATESARALKLTVADIFQSPRLTDLANLLSSRFLKEEQDEEEYMAEDDPEPFSLWYANEDLQRRHEQLQQIAQDCDVRVSSIQDVYPCTPLQEAMMAITSRQSAAYINRQVFELDDSIDVDRLQSAWRKLAQAVPTLRTRIAMSPGKASTLVQVVVDEEIEWQVSGSLEGYLERDQEQGMALGTPLIRFGLIHKDVSGQRFLVWTAHHSLYDGWSSRLIYQHLADIYHAGRVLDSPASFPRFIRFLAEQDNAEVRSASAKYWSEELEGEVMSNWPPLPHVDYQPRPGREIIKVVPLRQSGPSQVITPANVVRAAWAITMAQYAGHDDVVFAATVSGRNAPVWQVGNIVAPTITTVPVRTHIDWTDNITSFLDTIQKQAADMIPYEHTGLRTIKAIIPPQLGPALDLRNVLVVQTEGEGKTGAAPFPGVEPFSLGAAVDFDSHGLTVDCTVSATNLRVAFRFDETVLPTTHAENILSHFTHVVQQLCDPLLVKGRTLGDMDLVSPGDRTCIFERNDTVDISRWDACIHDLVGKQALAQPNAPAVCAWDGDLSYKELASYASRLAHQLIALGVGPEKKVGLCLDKSRWAVVAMLATLQAGGAIVPLGVSHPFSRVEVMVEDSAAVVILVDEQQHHRLADLPSNIPRVIVDSQSLEKLPPQSAPVTEVSPDNAAWINYTSGSTGAPKGMILEHGGLCTSMRTQSARMHISNKTRALQFSPFTFDVSISDISATLIYGGCVCLPSESDRMNNLAGSIQTMAVNFASLTPTVARLLSPAEVPTLKTLALTGEALKPDVVALWKIVPDVALYNTYGPSEGSVCTCNGPISSPEEAESIGTPMATRHWVTQPHNYHQLSPIGAPGELLIEGPLIARGYLNNPEKTAASFVPPPGFLTKPSGSRIYRTGDLVRQNTDGSFTYLGRRDTQVKIRGQRVEIGEIEHQIVNHLASVQTAVVHLLEAIGLVAVVELREAETVAEIEPAGTIAPSPALCSQFSDLRQALLRVLPDYMAPALFVPVPSIPTNVSGKLDRRAVHELLMSLPTDNLGRWTAEQENMPKAILQPATEMEKMLQELWARMLKIPADNVSPQDDFFRLGGDSVTAMRMVATATRTSRHLRLVVTDIFQHPRLSELAQVLEERVQKDLEQRDIQSTEPIDPEPFALFADGSDLDAQGREQRLAAVAEQCSVAVEQVQDVYPCTPLQEGLLANTSRQQAAYVSRQSYVLSNNIDLARFKAAWEALAKAAPILRTRIVIGAEGSCQVVVKGPIEWLHHSGALEDYIQQDKAREMGLGQPLARYAIVQELSGEQFFVWTAHHSMYDGWTVRLLCQELINLYNREDHVPRPVPYTRFIRYLYEINRAGSLEFWKQQLEGDDVEADWPRLPHVGYEPRPRSTLSVNIADPGNDESSGIVIANILRAAWGLVMAQFSGHNDIVYAANVSGRTAPVPGVTDIIGPTIATVPVRMHFNPRALMTVESFLHGVQTQSQQMIDHEQTGLIAMRNHPNLQLRNLLVIQPADEGDTVLDFPGIEAVPSAVEDFDSYGVNIECVLGMTIRVQARFDDHIVAATYMKRVLDQFAYIVEQLCDPRLRALPLQQLNLLSPNDQQQISSWNAAAPESVEQCVHEMVEEQAMAHPTKLAVWAWDGKFTYQELAHLAQLLADQLVSLGIGPERMVGVCMDKSKWAAVAFLAILKAGGVVVPLGVSHPIRRIETILNDTMSDLVLVDAKHCQRLSVEGLLRQRLLVVDDKLQQHGSSRPRAGQQAKPITPDHAAWVIYTSGTTGLPKGAVLDHRALSSSIRAHGTRYKFGPQTRKLQYSAHLFDGTIEDYFTTLSWGGLCCVPSEDDRLDMRRLTAFMRETEVNALATTYTVAGLLTPEEVPSLQTLVLGGEPATVEVTDTWRSKVDLFNCYGPSECTVFSSAAGPRVAVAELHNIGHPIGTRLWVVNPDNPGSLCPVGAPGELLIEGPQLARGYLNDEAKTRTAFLTDLEFMRQFKIPPSTRVYRSGDIVRQKDDGSFVYVARRNTMQVKIRGQRVEVGEIEHQVGLHLAETRAVAVELLKQGVHGLPVLVAVVDFADNSQYRLADGDQKPTPKEELLPPTPAAQQAFTKLQVALSQVLPSHMIPSIYLPVTQLPRNISGKLDRRALRELLDQLSYEAIHQYMDIDGGEKAAPATAMERTLQSLWAQTLGMDIDRIGAHDNFFQLGGDSVAAMRLAAIVQQQEQLQLTVGDILSHPCLSDLANLLADGAPTEGTTETDPEPFSLWCTVPDEDLPTIAVKLGVAVEQIEDIYPATPLQEGFIAVTARQSAAYISRQVYKLSATLLDLDRFKASWETLVNTTPILRTRLSIGRDGHAVQVVVRDSIGWRYGTDLSSYVAQDREEGMRLDEPLMRYAIITEPTSGSCYFVWTAHHSIYDAWTIRAISKSLAEIYTSTSPHSIPQPTASFSRFIRYLTNTDTDAIKDFWHEQLAGDVVADWPPLPQNDYQSLPRGRIQKTIKIPERSSGILESTTLRGAWSIVMSQYAGSSDVVFAATVSGRNAPVPQINDIAGPTLTTVPVRVSVDSSLSVNQFLQSIQQQSTDMIPYEQTGLQRIKASLPEANQSALNLRNLLVIQLAAEAESNTLALPGWEAQPAPFEDFGSFGLQIECTPIPGSHAIDVNIQYDEKVISTTAVTRVAEHFVHVAEQLFNPGLINSALTEIQLQLSSEHKDVMLRQNTHVPPYLNRCIQEMVYERAALQPNAPAICAWDGNWTYAEVTDLAASFASYLSTELQIGPTQMVGVCMDKSKWAVVAMLAILCAGGTVVPLGVNHPLSRIQVMAQDTGLGVILVDNKQRERLFDLNHRLITVDAQHIQGLPVLGKQERTSMTQKTGVTPDDIAWIIYTSGSTGIPKGVMLEHRALATSMEAHGSTFGFGTHTRILQFAAHTFDATIQDMFTTLYKGGCVCIPSEYDRVNRLTESMASMSVNCATLTSTVASLLAPEELPSMQTIILVGEPVTPAAVALWLPHATVLNAYGPSECSIHSSCSDPITDPALAPNIGRPLATNFWVVDPNNYHSLRPIGAPGELLIEGPIQARGYLNDIDKTNAAFVIDPDFMKQLGLSGSQRRLYRTGDLVRQNDNGTLTHMGRRDLQVKIRGQRVEVGEVEYQIQRKLPSARTVAVEPLQHGDKDKHITLIAIMDLSDRAVTDELNAAKAPEPLPVTASLQATFHDLRNSLLQVLPAYMVPAAYLPVDRMPMNASNKLDRRAIRELITHHSLEDLQQYLGGGTDDNVKTAPRTVMEQQVHALWVEVLGLSEDAVGVYDNFLQLGGDSLTAMRIVAAAGQTGEVRVSVEDIFMHPTVADLALVLSERGSSDRAVEQEQEDPAPYQLWTEQNNFPADQIEENLEAIAAQCAVDRALIEDVYPCTPLQAGLMAITARQPAAYVSRQVYTMSSSIVDRATFQKAWQQLAAGTDILRTRIVMAPDSSSQALQVVVRDTIHWELGTNLDEYLRRDSERGMALGEPLVRYGIVEEPSGKSYFIWTAHHALYDGWTLGALSKRLGDIYQNRALSTQSVPYSRFIRYLQHGRSSLESSASYWREQLQGDAMANWPRRPALDYQPMPRHNLQRTISLGSSQTLVTTSTILRAAWALVIAQYAGHNDVVFAATVSGRSAPVAGIADIPAPTITTVPVRIRVDGNRSVADYLQAVQRQAIDMIYYEHTGLQTIKALVPDLASTLDAGSLMVIQPTDQSAMESGLDFPGLDMVPMPIAPFNSHGVTLECKLGAQDVTLDIHYDSNIIAPEQLSLVIDYFASLVLRLGNPAATSSPVADLLAVSEKDERQIRAWNSTVPPRLDKCIHEMVQEQVARTPGEIAIQAWDGQLTYREFHDLAASLAHHLAALGVGPETLVGVCMAKSKWGAVAMLAIMQAGGAIMPLGVSQPVARIQNILETSQAAFILVDEEQMDRLNQLSTPGQTPKLIFVEDLLMEIPSYTQPPATDVTPDNASWAIFTSGSTGTPKGVIIEHGTMSTSLDEQGRWLGLSQETRFLQFASYTFDNVITDTFATTSFGGCVCIPSESGRMDRLEEVMVEMKVNTAMLTSTVAQQLSPTQLPLMQKLILTGEPVRPDVVRTWLDHAEIYNAYGPTEGSMSTCTRPYTNAFEASNIGHPLATRLWVVQPDNPHLLSAIGAPGELYIEGPFLARGYLNDPVKTDALFLMDPPFTQRLGLTGRRVYRTGDLVQQNEDGTLIHLGRHDSQVKIRGQRVEISEIEHQITQHLPEASTVAVFILDDNPITLVAAVEFNMKSPHRLGPHSAFKGLLAPTVAMRVDFTRLYGALSQVLPIYMVPTVFIPMHEMSRNLSGKLDRRLVQTLLKEIPTTELRRYRLGEGPKIAPSTAMERQLQSIWSKALDLPEDQVGAHDNFFHIGGDSLVAMRIIAIARAQKLKLTVADLFKYPCLSEVAQVVEDRVAASSITLAVDEEPIAPSPFSLIAAENIEIYLQRIASRMPGCRAQDIVDILPTTDFQALTVAEALTTPGTANFAHFFLDGDGSCDVEALRKSCLQLIEAMPELRTAYVFDQGRLLQVVLRVYEPEIKILQTNDATMEEVTSDLISKQMFQAPHLGQPFTVITIIEESASSRHRVVLRLTHAEYDAVSMQSIWRQLRALYEGTTLKPRPTFASFLYSQRQKITTQTYNYWRTLLDESTMTPLSTPTPMPTSTIGHYPSKVAQLRPCRVHINRSSVEGITSAVFIKTAWAIALSRLSNRQDIIFADTVSSRGTVDESLMEATGCCVTLLPVRVKLTPETSMQDVLLELRTQQVQSLERAQLGFREILHECTNWPTSTRFTSAINCISQGGNGAFTMRGTNYWLSNFQANNATWTVDLGVTAVMHDNGDVDLRMAYLPTRISEDAAYKYLNTLQDTLQAILDSPGLLVSNFLSRALGGSLGDRKGASDPKIEVIEPEQEPQPLESTDKMTYLDLKKTPEWEEVLRGRRGIVSPGRTSLSFSQRGGDLLDALYLSSLQKDADGGRYISPMALLEGSRCEEAEKSASVTSSERRLATI
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent (PubMed:22998630).  Linoleoyl-AMP, produced by the fatty-acyl-AMP ligase ecdI, is transferred to the initiation carrier domain (T0) of ecdA (PubMed:22998630).  The linoleoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-ornithine, L-threonine, L-proline, L-homotyrosine, L-threonine, and 4R-methyl-L-proline to form the linear hexapeptide (PubMed:22998630).  Thereafter, the terminal condensation (C7) performs macrocyclization of the NRPS product and the cyclic scaffold is released from ecdA (PubMed:22998630).  All six of the amino acid residues are hydroxylated, including 4R,5R-dihydroxy-L-ornithine, 4R-hydroxyl-L-proline, 3S,4S-dihydroxy-L-homotyrosine, and 3S-hydroxyl-4S-methyl-L-prolin (PubMed:22998630).  In the pathway, all the hydroxylation reactions are proposed to occur following completion of the cyclic peptide, so the unhydroxylated precursor produced by ecdA will undergo six rounds of hydroxylation (PubMed:22998630).  Five hydroxylase genes (ecdG, ecdH, ecdK, htyE and htyF) are embedded within the echinocandin B (ecd) and L-homotyrosine (hty) clusters (PubMed:22998630).
What are the official names of this protein?
Nonribosomal peptide synthetase ecdA, NRPS ecdA, Echinocandin B biosynthetic cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.