PharMolix/UniProtQA huggingface dataset:
Protein: SECA_PROMS
Sequence: MLKLLLGDPNTRKLKRYQPIVEEINFLEEEISQLTDDELRKETQNLKSNISAELDFKKQKELLEEFLPKAFAIVREASKRVLDMRHFDVQLIGGMVLNECQIAEMKTGEGKTLVATLPCYLNALTGKGVHVVTVNDYLARRDAEWMGQVHRFLGLSVGLIQQDMNPVERKKNYDCDITYATNSELGFDYLRDNMATDISEVVQRKFNYCVIDEVDSILIDEARTPLIISGQVERPQEKYQKAAELSLALIKAKELSKDGIDPEGDYEVDEKQRSCILTDQGFAKCEEYLGVNDLYNPQDPWAHYITNALKAKELFIKDVNYIIKNEEAVIVDEFTGRVMPGRRWSDGQHQAIEAKESLKIQPETQTLASITYQNFFLLYPGLAGMTGTAKTEEVEFEKTYKLESTVIPTNQIRKRQDWSDQVFKTEIGKWKAVAKETAKIHRDGRPVLVGTTSVEKSELLSSLLSAEKIPHNLLNAKPENVEREAEIVAQAGRAGAVTIATNMAGRGTDIILGGNSDYMARLKLKEILIPLLVKPDNEHKPPIPKQRNSKSKGGFSRKAGSNLKKKISNSSTNLFPCKLDEVIEKKLSLLSDELVKNWGDKQLSVLELDDRIATAAEKAPTDDKLIRLLRESLSDVKNEYEKVLIHEEEKVREAGGLHVIGTERHESRRVDNQLRGRAGRQGDLGSTRFFLSLDDNLLRIFGGDRVANLMNAFRVDEDMPIESGMLTRSLESAQKKVETYYYDIRKQVFEYDEVMNNQRKAVYGERLRVLKGIDLKRQVIGYGERTMIEIVDAYINPDLPPEEWNIEQLISKVKEFIYLLDDLKVEDINLLSIEELKNYLQEQLRIAYDLKESQIDKIRPGLMREAERFFILQQIDNLWREHLQSMDSLRESVGLRGYGQKDPLIEYKNEGYDMFLEMMTNMRRNVIYSMFMFQPKTDKNDKN
What is the function of this protein?
Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: SAHH_LEIDO
Sequence: MADYKVKDISLAEWGRKAIELAENEMPGLMELRREYGPSQPLKGAKIAGCLHMTVQTAVLIETLKALGADVRWSSCNIFSTQDNAAAAIAKAGVPVFAWKGETDEEYEWCIAQTVKGFSGDGLPNMILDDGGDLTNLVIDHHPELVPKIFGISEETTTGVKNLYKRLSKGNLPMCAINVNDSVTKSKFDNLYGCRESLVDGMKRATDVMIAGKTCCVCGYGDVGKGCAAALRAFGARVVVTEVDPINALQASMEGYQVALVEDVMADAHIFVTTTGNDDIITSEHFPHMRDDAIVCNIGHFDTEIQVGWLEANAKEHVEIKPQVDRYTMENGRHIILLAKGRLVNLGCASGHPSFVMSNSFTNQVLAQIELWSNRDNGKYPRGDKAGVFFLPKALDEKVAALHLAHVGAKLTKLTPKQAEYINCPVNGPFKPDHYRY
What is the function of this protein?
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOCAD_HUMAN
Sequence: MSDDIRKRFEFPNSLIQSQAVGHLIAAVLKENGFSEKIHQSTNQTPALNLLWEKCCSDNVVVRTACCEGLVALVAQDHAEFSYVLNGILNLIPSTRNTHGLIKAIMHLLQMQALKEGQGGEKNIQSIYTIRNHPHPLITVLEHRPDCWPVFLQQLTAFFQQCPERLEVSCIQIMAPFLWYLYCEPSQLQEYAKLRLALLKVLLQPQVLCDKDQPSILEQQILQLCCDIVPCLQVKDLIQTTEAMMFIEEVCLSLLRHPVFWKIQLTQMSLQLLCVSEVSLKITGECSSSIHLLEHSVELLKEDFPVELVIIGIALLLLQTPASQQKPILNLALKLLSVTEDQKIPKSSLLLVMPILQILSSTALEDCISVDEEGPSRQQLALNLLEMIQQECYRDDHQKLSYKLVCPVTSMYGTIFTAWRILEVMTDSSAASDWLASVESLLPITAVIPAPAFLLLAHLLVEDKGQNLHQILKVTTELAQADSSQVPNLIPVLMFKLGRPLEPILYNDILYTLPKLGVHKVCIGQILRIIQLLGTTPRLRAVTLRLLTSLWEKQDRVYPELQRFMAVSDVPSLSVGKEVQWEKLIAKAASIRDICKQRPYQHGADMLAAISQVLNECTKPDQATPAALVLQGLHALCQAEVVCIRSTWNALSPKLSCDTRPLILKTLSELFSLVPSLTVNTTEYENFKVQVLSFLWTHTQNKDPIVANAAYRSLANFSAGEHTILHLPEKIRPEIPIPEELDDDEDVEDVDLSVPGSCYLKLLSLTPPLVLPALEEFFTSLVKQEMVNMPRGIYHSALKGGARSDQGKTVAGIPNFILKMYETNKQPGLKPGLAGGMLFCYDVSMYQSKDGKPLNRLMASRGRSFKQTSLALVHEVHIQLSEWHRAIFLPQAWLAYMNRAYHAILQGRLGELELQLKHGKEEPEEVQYKKSTAWLWVRDMLTDEITKAAAKESPVVKGNALLALSSLAVVVSRHEASLSSDSDGLLEVQPNFLSMKEWVSMVLDTLLVIVDSHYQPRGQLLSWFYYKSYSGENTASAIARSAAATALSLLVPVFIISCKEKVEEILNMLTARLPGKPSADESQAVQIHMGLALGMFLSRLCEEKLSDISGQEMNLLLMKSLDALENCCFDTSLEYNTGCILGVGLVLSLMSHSSQMQSRVHVAALLRKLSAHVDDSGSQSRTFQEVLAYTLSCVCTSAFSAGIIEATEAEDVMNKLRLLVENSQQTSGFALALGNIVHGLSVCGHGKAEDLGSKLLPAWIRIVLTEGTPTMLCLAALHGMVALVGSEGDVMQLKSEAIQTSHFQGRLNEVIRTLTQVISVSGVIGLQSNAVWLLGHLHLSTLSSSQSRASVPTDYSYLPESSFIGAAIGFFITGGKKGPESVPPSLLKVVMKPIATVGESYQYPPVNWAALLSPLMRLNFGEEIQQLCLEIMVTQAQSSQNAAALLGLWVTPPLIHSLSLNTKRYLLISAPLWIKHISDEQILGFVENLMVAVFKAASPLGSPELCPSALHGLSQAMKLPSPAHHLWSLLSEATGKIFDLLPNKIRRKDLELYISIAKCLLEMTDDDANRIAQVTKSNIEKAAFVKLYLVSQGRFPLVNLTDMLSVAVQHREKEVLAWMILHSLYQARIVSHANTGVLKRMEWLLELMGYIRNVAYQSTSFHNTALDKALDFFLLIFATAVVAWADHTAPLLLGLSASWLPWHQENGPAGPVPSFLGRSPMHRVTLQEVLTLLPNSMALLLQKEPWKEQTQKFIDWLFSIMESPKEALSAQSRDLLKATLLSLRVLPEFKKKAVWTRAYGW
What is the function of this protein?
Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver.  May be involved in the regulation of RNA degradation by the exosome complex (PubMed:35864190).  Potential tumor suppressor in gliomas.
What are the official names of this protein?
Focadhesin.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell junction, focal adhesion. Note=Colocalizes with VCL in astrocytes.
Protein: PYRE_ECO7I
Sequence: MKPYQRQFIEFALSKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVAMAEHHDLDLPYCFNRKEAKDHGEGGNLVGSALQGRVMLVDDVITAGTAIRESMEIIQANGATLAGVLISLDRQERGRGEISAIQEVERDYNCKVISIITLKDLIAYLEEKPEMAEHLAAVKAYREEFGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: ABDH_SALPB
Sequence: MQYQLLINGVLVDGEGERQSVYNPATGEVILEIAEASPAQVDAAVLAADSAFAEWGQTTPKARAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRFFAGAARCLSGLAAGEYLEGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLTALKLAALAKDIFPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHTAPAIKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDALVEKLGNAVSSLKMGTPEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGSQTEGKGYYFAPTLLADARQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWTQDVGRAHRLSARLQYGCTWINTHFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMVKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal.  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: RL27_LACDB
Sequence: MMMNILSNAKLLAHHKGGGSTTNGRNSAGRRLGAKRADGQEVHAGSIIYRQRGTKIHPGKNVGRGGDDTLFALTNGVVKFERLGKYKKQVSVLPVEDAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: BPT_BURP0
Sequence: MTHPTELPLSPLSALQFYATAPYPCSYLDGRVARSQVATPSHLINSDIYTELVKAGFRRSGVFTYRPYCDGCRACVPVRVPVDAFAPNRTQRRTWKRHRALVATVAALHYDEEHYALYMRYQSARHAGGGMDRDSRDQYEQFLLQSRINSRLVEFRDLDPAENGASTLRMVSMIDILGDGLSSVYTFFDPDESHASYGTYNILWQIEQAKSLRLPYVYLGYWIRESPKMAYKANFHPLEGLVDGRWKVLDPTLADLPPVDAALARAPLPGGHSGTR
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXL2_RABIT
Sequence: MMASYPEPEEAAGALLAPESGRAAKEPEAPPPSPGKGGGGGGGGGSAAEKPDPAQKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGAAGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSPGAAAVVKGLAGPAASYGPYSRVQSMALPPGVVNSYNGLGGPPAAPPPPPPPPPPPHPHPHPHAHHLHAAAAPPPAPPHHGAAAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSYWDHDSKTGALHSRLDL
What is the function of this protein?
Transcriptional regulator.  Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity).  Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity).  Has apoptotic activity in ovarian cells (By similarity).  Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity).  Activates SIRT1 transcription under cellular stress conditions (By similarity).  Activates transcription of OSR2 (By similarity).  Is a regulator of CYP19 expression (By similarity).  Is a transcriptional repressor of STAR (By similarity).  Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity).
What are the official names of this protein?
Forkhead box protein L2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL24_GEOSM
Sequence: MLGKKLHVKKNDTVVVIAGKDRSKSGKVISIHPKKDGVIVEGVNVVKRHQKPRGSEQGGILEKEAPVHISNVMLLCGKCNKPVRTKTTVLEDGKKARCCVKCGESFDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: LIFO_BURO1
Sequence: MAAREGRAPLARRAAIYGVVGLAAIAGVAMWSGAGPHRGTGAAGDAPDAAAVGGVAAAAPQAAVPASAGLPPSLAGSSAPRLPLDAGGHLAKSRAVRDFFDYCLTARSDLSAAALDALVVREIAAQLDGTVAQVEALDVWHRYRAYLDALATLRDAGAVDKSDLGALQLALDQRASIAYRTLGDWSQPFFGAEQWRQRYDLARLKITQDRSLTDAQKAERLAALQQQMPADERAAQQRVDRQRAAIDQIAQLQKSGATPDAMRAQLTQTLGPEAAARVAQMQQDDASWQSRYADYAAQRAQIESAGLSPQDRDAQIAALRQRVFTKPGEAVRAASLDRGAGSAH
What is the function of this protein?
May be involved in the folding of the extracellular lipase during its passage through the periplasm.
What are the official names of this protein?
Lipase chaperone, Lipase activator protein, Lipase foldase, Lipase helper protein, Lipase modulator.
What is the protein family that this protein belongs to?
Belongs to the lipase chaperone family.
Protein: ISPF_ACIBY
Sequence: MVAQIRIGQGMDVHAFEEGNFVTLAGVQIPHTHGLKAHSDGDVVLHALCDALLGALALGDIGQHFPDTDPEFKGADSRVLLKHVYQLILDRGYHLNNADITVACERPKLAKYNLEMRQSIADVLNVDLNQISIKATTTEKLGFTGRQEGILATATVLISH
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: TPMT_BORPD
Sequence: MDAEFWLERWRDGRTHFHQQRVTPLLAKYWPTLQLPPGCRVLVPLCGKTLDMVWLAQQGHQVLGVELSSLAVEQFFAENGLQATVREAGPGTYYSAGDISIYCGDIFDLGADVLGDCVGAFDRAALVALPAAMRPRYARHVYGQLSAAYRGLLITLDYDQSQMDGPPFSVRDDEVQAIYAGHSEAVLIDRRDILSKEPKFAERGLTQLDTLVYRLQRQG
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HELS_THEVO
Sequence: MKISDLGYDESFLDLFEGNDFELYDHQRMAIEQFRKGKNIMVSVPTAAGKTLIAYSAIYETFKKKLKSIYIVPLRSLAMEKYEELSRLRELGMRVKLSIGNYDDTPDFIKRYDVVILTSEKADSLMHHDPYMMEEVGLMVIDEIHMIGDEYRGPTLETVITTARYVNPETRIIALSATVSNASEIAEWLNASLIKSSFRPVPLKVGILYRNRLFLDGDARSDVDINLLVKETVDDGGQVLIFVSSRKRAEDMAKNLSQLFDPINDLKVSSEDANVYDDLLNEMLPHGVSFHHAGLSNEQRSFIEKAFRHRKLKVIVATPTLAAGVNLPARLVIVKDVTRYGDLGITYLSNMEVKQMIGRAGRPGYDQYGIGIIYAASANSYQVVKEYISEEPEPVDSYIGKPEKVRFNTLAAIAMGLATSQVEMEEFYRSTFYYAQNGEDEIPNRINESIKFLKENGFIKEKDSLRATEFGKMISNLYIDPESAIILKKYFDDNDDIDTALYYISLCREIAPINMQDDYAAMEFLESIGHIDGDIEAAKTALVLREWISEASTRRIFEMYGVAPGDLQARVNNADWISYSLAHLASIFKPERRRKLEILNMRIKEGIREELMDLVLIPAIGRVRARRLYEAGIHNVQELAFSDPSRIKMLYGFSDTLANAVVKRAKAIVSERIR
What is the function of this protein?
DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
What are the official names of this protein?
ATP-dependent DNA helicase Hel308.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Hel308 subfamily.
Protein: U235_DICDI
Sequence: MTKKGSSNSSKQQQQQQQIIINNNAKVDEPIIKINVNVHPNSKESSIVSFEDQILSLRISEPPIDGKANIGVIEFLSKELNIRKSNIEVGKGSKSRNKSVEIDISSENITKDELFERIKSKLNN
What are the official names of this protein?
UPF0235 protein.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: PPE69_MYCTO
Sequence: MPDPGWAARTPEANDLLLKAGTGVGTHLANQTAWTTLGASHHASGVASAINTAATAASWLGVGSAASALNVTMLNATLHGLAGWVDVKPAVVSTAIAAFETANAAMRPAPECMVNRDEWGVDNAINPSVLWTLTPRIVSLDVEYFGVMWPNNAAVGATYGGVLAALAESLAIPPPVATMGASPAAPAQAAAAVGQAAAEAAAGCGMRSAYQGVQAGSTGAGQSTSAGENFGNQLSTFMQPMQAVMQAAPQALQAPSGLMQAPMSAMQPLQSMVGMFANPGALGMGGAAPGASAASAAGGISAAATEVGAGGGGAALGGGGMPATSFTRPVSAFESGTSGRPVGLRPSGALGADVVRAPTTTVGGTPIGGMPVGHAAGGHRGSHGKSEQAATVRVVDDRR
What are the official names of this protein?
Uncharacterized PPE family protein PPE69.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: RS20_SHESA
Sequence: MANSKSAKKRALQSEKRRQHNASRRSMLRTYVKKVIAAIKAGDHKTATEAFAAAQPIVDRMATKGLIHKNKAARHKARLNAKIKALAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: XYNB_ASPNC
Sequence: MLTKNLLLCFAAAKAALAVPHDSVAQRSDALHMLSERSTPSSTGENNGFYYSFWTDGGGDVTYTNGDAGAYTVEWSNVGNFVGGKGWNPGSAQDITYSGTFTPSGNGYLSVYGWTTDPLIEYYIVESYGDYNPGSGGTYKGTVTSDGSVYDIYTATRTNAASIQGTATFTQYWSVRQNKRVGGTVTTSNHFNAWAKLGMNLGTHNYQIVATEGYQSSGSSSITVQ
What is the function of this protein?
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
What are the official names of this protein?
Probable endo-1,4-beta-xylanase B, Xylanase B, 1,4-beta-D-xylan xylanohydrolase B, Endo-1,4-beta-xylanase G1, Xylanase G1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 11 (cellulase G) family.
What are the subcellular locations of this protein?
Secreted.
Protein: HNRPC_PONAB
Sequence: MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAAEMYGSVTEHPSPSPLLSSSFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGFNSKSGQRGSSKSGKLKGDDLQAIKKELTQIKQKVDSLLENLEKIEKEQSKQAVEMKNDKSEEEQSSSSVKKDETNVKMESEGGADDSAEEGDLLDDDDNEDRGDDQLELIKDDEKEAEEGEDDRDSANGEDDS
What is the function of this protein?
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles.  Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.  Single HNRNPC tetramers bind 230-240 nucleotides.  Trimers of HNRNPC tetramers bind 700 nucleotides.  May play a role in the early steps of spliceosome assembly and pre-mRNA splicing.  N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein C, hnRNP C.
What is the protein family that this protein belongs to?
Belongs to the RRM HNRPC family. RALY subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Component of ribonucleosomes.
Protein: COM1_SCHPO
Sequence: MNEEEHNKSVHWSIVYRQLGNLLEQYEVEIARLKSQLVLEKKLRIQVEKELESVKTKQISSSASSKVSSNTIQELDSTTDEDEIPGSDTVDEEDPSLNAPFSEKNQSVKIPPHSPTLPVQNASAFVKPISVPLGNVKEEKFLDTNPIGAESFESSDGEMHLRARSPEDMILLRETQPLAPLDINTLGVSDNRQKKGTEKKRPFEPEFLNDDVIRGNKRKALPAYECPDCQKFYELHGPVKESSVAPTWNDENRLGGGSLPNCKHQPLVQKVGRHRKLNIPKPIPNGFWESDFVD
What is the function of this protein?
Endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends.  Required for the formation of RPA-coated single strand DNA adjacent to the DSBs where it functions together with the MRN complex in 5'- 3' resection.  Required for the repair of programmed meiotic DSBs.  Involved also in an rhp51 recombinase-dependent recombinational repair pathway.
What are the official names of this protein?
DNA endonuclease ctp1, Double-strand break repair protein ctp1, Meiotically up-regulated gene 38 protein, Nbs1-interacting protein 1, Sporulation in the absence of SPO11 protein 2 homolog, SAE2.
What is the protein family that this protein belongs to?
Belongs to the COM1/SAE2/CtIP family.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates at DSBs.
Protein: RTN3_RAT
Sequence: MAESSAATQSPSVSSSSSGAEPSTLGGGGGSPGACPALGAKSCGSSCAVGLSSLCSDEPPSKIMTSSFLSSSEIYNPDPTTPLGSETLGSHLVAKDGKDPLVLLDKKTLDSPQGTNKDRVDTPVSLAADIPCSHPSIPDSFPEQPTFLSKETDPTEEWVVKNQEPKNPSEVPSGEDRSALDLGQRKAEHICTHSLSPSEPAVASVEKDSPESPFEVIIDKATFDREFKDLYKESTDDLGGWAAHGDRESPADLLEMNDKVFPLRNKEAGRYPSSALLGRQFSHTTAALEEVSRCVNDMHNFTNEILTWDLDPQAKQQADKSPCTTESTGLDRSEHRSEIPVINLKTSPQQKMPVCSFNGSTPITRSTGDWTETFTEGKPVKGYLSSTKEAGGKGVPDSSQPISGSGAATVEVTLPDLRGTWPNSVLGEVTEVDSSGESDDTVIEDTTENPSVKNNKVLPEKSDSLPSAAVKTSERENKETTSHETVRSEMYENSEQQQAHAETPTQRSLEGQMSPQVPNMLNEVIPENLAMTDTTRVCSAAPPSVLSETGFSLTVPASAKSESLLGKNVEDTDGSSPEDLMAALTGTEEKGTVDKEKGDVLEAVLEKIANVKNTLPVELLHENKLSSSETKNTKSKYSEHSRETNGGAPKVSSDLEQEQLTIRAIKELGAKQVQAERMSPGGKLKRTFDPQSGPQNSSDILEHTDITTGSDLGIPKKPTIIKDTRIDSISSLTKTETVNKHVLARLLSDFPVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRVYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHSYMNAAMVHVNKALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLVFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE
What is the function of this protein?
May be involved in membrane trafficking in the early secretory pathway.  Inhibits BACE1 activity and amyloid precursor protein processing.  May induce caspase-8 cascade and apoptosis.  May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress.  Induces the formation of endoplasmic reticulum tubules.  Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.
What are the official names of this protein?
Reticulon-3.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: SYI_BACAH
Sequence: MKKVDVKESAVGRETRIRKQWNEQSIFEQSIQNREGAQSFVFYEGPPTANGLPHVGHALGRTIKDVVARYKTMVGYKVLRKAGWDTHGLPVELGVEKQLGISGKHEIEEYGIEPFIQKCKESVFTYEKQWREFTESIGYWVDMDDPYVTLENPYIESVWHILGTIHEKGLLYKGHRVSPYCPSCQTSLSSHEVAQGYKTVKDLSATVKFEVKDSENEYFLGWTTTPWTLPANVALAVHPNMEYVKAKQEGHVYIVAKERVQDVLKEDYEVLSVHKGEELVNTSYMPPFPMKEVTNGYHVIAADFVTADSGTGLVHIAPAYGEDDYRVVQSEGLSFLHVVDEKGEYTEAVPFLKGKFVKDCDVDIVRYLAKEGLLYHKEKYEHSYPHCWRCDSPLLYYAGESWLIRTTAIKDTFLQNNDSVTWYPDHMKHGRFGKFLENMVDWNISRNRYWGTPLNVWECESCDHQFAPKSIADLRKHSTKETPEDLELHKPYVDEVQVCCEKCGGTMTRTPEVIDVWFDSGSMPFAQYHYPFENKELFEEQFPADVIAEGIDQTRGWFYSLLAVSALYTGKAPYKRVLSLGHVLDEEGQKMSKSKGNALDPVDLVEKFGADALRWALLVDSAPWNAKRFSERTVLEAKSKFVDTLINVYSFYVLYANLDEYNPHETYDVKRTKLDEWVLSRLHSTTKKVRTALDDYQFTNAAREIAALVDEVSNWYVRRSRNRFWESGMNAEKAAAYETLHEVLVTISKLIAPFTPFVAEDIHVNLTGNSVHLEDYPVVNESLLQPKLEAEMNAVLQVVELGRSNRNQHSLKVKQPLAELVLLEHNENDMDWESYRDIVMDELNVKTFHVELDETKYTSYQLKLNFKKAGPKFGKNVNAVNGWLKQLSQAEVQNFVSTERAVYEVASGEEVVVTAEDVMVEKVAKSGFSNTTNGQYTVMLDTNVTEELLQEGVAREFIRAVQEYRKQLNLPVNLRVDVILDTEEELQQTLTNHKELLKENLLVKQFTFGHLTNEDDELSLGETKVRIKLSSAN
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_YERE8
Sequence: MDKKAARIRRATRARRKLKELGATRLVVHRTPRHIYAQVIAPNGSEILVAASTVEKAINEQLKYAGNKDAAAAVGKAVAERALEKGITKVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ISPG_MARMS
Sequence: MHFESPIKRRHSRQIMVGNVPVGGGAPISVQSMTNTETCDVDATVAQIRAIADAGADIVRVSIPSMDAAEAFKKIREAVSIPLVADIHFDYKIALKVAEYGVDCLRINPGNIGNKDRIRAVVDCARDKNIPIRIGVNAGSLEKDLQKKYGEPTPDALVESAFRQIQYFDELDFHEYKLSLKASDIFMTVEAYRKIASQIDNPLHLGITEAGGLRSGTVKSSIGLGLLLMDGIGDTLRVSLAADPVHEIKVGWDMLRSLKLRNRGINFIACPSCSRQNFDVIKTMNELEERLDDITIPMDVAVIGCVVNGPGEAKEADIGLAGGSPNNLIYQDGKPDSKTKNETLVDDLERMIRKKALLKEQELANIIVKN
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: YOAH_ECOSM
Sequence: MFAGLPSLTHEQQQKAVERIQELMAQGMSSGQAIALMAEELRANHSGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: ACDH2_NOVAD
Sequence: MAKMKCAIIGSGNIGTDLMIKLLKGSDTLELAAVVGIDPASEGLAMASERGVPTTHEGIEGLCRMPQYADIGIAFDATSAYAHKAHDEILARDGKLMVDLTPAAIGPATIPPVNPAVDAAVRNINMVTCGGQATIPIVAAVSQVAKVHYAEIVASVSSRSAGPGTRANIDEFTRTTARAIETVGGAAKGRAVIILNPAEPPMIMRDTIFTLSEMVDEDKVRDSVLAMIARVQSYVPGYRLKQEVQFERFGSNRPLKIPGYGEFEGLKTSVFLEVEGAGDYLPNYSGNLDIMTAAAKAAGESLAKTHMEKTAA
What are the official names of this protein?
Acetaldehyde dehydrogenase 2, Acetaldehyde dehydrogenase [acetylating] 2.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.