PharMolix/UniProtQA huggingface dataset:
Protein: PT1P_SALTY
Sequence: MLTRLREIVEKVASAPRLNEALNILVTDICLAMDTEVCSVYLADHDRRCYYLMATRGLKKPRGRTVALAFDEGIVGLVGRLAEPINLADAQKHPSFKYIPSVKEERFRAFLGVPIIQRRQLLGVLVVQQRELRQYDESEESFLVTLATQMAAILSQSQVTALFGQYRQTRIRALPAAPGVAIATGWQDATMPLMEQVYEASTLDTSLERERLTGALEEAANEFRRYSKRFAAGAQKETAAIFDLYSHLLSDARLRRELFAEVDKGAVAEWAVKKIIEKFAEQFAALTDNYLKERAGDLRTLGQRLLFHLDDSVQGPNAWPERFILVADELSATTLAELPQDRLAGVVVRDGAANSHAAIMVRALGIPTVMGADIQPSVLHRRTLVVDGYRGELLVDPEPVLIQEYQRLISEEIELSRLAEDDVNLPAQLKSGERVKVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQVAQYQGMLQMFNDKPVTLRTLDVGADKQLPYMPISEENPCLGWRGIRITLDQPEIFLIQVRAMLRANAATGNLSILLPMVTSIDEVDEARRLIERAGREVEEMIGYAIPKPRIGIMLEVPSMVFMLPHLANRIDFISVGTNDLTQYILAVDRNNTRVASIYDSLHPAMLRALSMIAQEAEKHGLDLRLCGEMAGDPMCVAILIGLGYRHLSMNGRSVARVKYLLRHIDFEDAQTLARRSLEAQMATEVRHQVAAFMERRGMGGLIRGGL
What is the function of this protein?
Component of the phosphoenolpyruvate-dependent nitrogen-metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism.  Enzyme I-Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr).  Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins.  Enzyme I-Ntr is specific for NPr.
What are the official names of this protein?
Phosphoenolpyruvate-dependent phosphotransferase system, Enzyme I-Ntr, EINtr, Phosphotransferase system, enzyme I.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC5A8_MOUSE
Sequence: MDASRDIGSFVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRCIRLCGTILFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFASVIIQASITQHGINKILSDAFNGGRLNFWNFDPNPLQRHTFWTIVIGGTFTWTTIYGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPWTSKKVSAIDQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSLSWISQGMSVLYGALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSIGALTGLLAGFAISLWVGIGAQLYPPLPERTLPLPLETYGCNITHNGSDWMSTTEMPFSTSAFQIHNAERTPLMDNWYSLSYLYFSTIGTLTTLFVGILISLSTGGRKQNLDPRFLLTKQDFLSNFDVFKKRNHVLNYKLHPVEVGGTDNPAFNHVELNFTDHSGKINGTRL
What is the function of this protein?
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1.  Catalyzes passive carrier mediated diffusion of iodide.  Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane.  May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract.  May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
What are the official names of this protein?
Sodium-coupled monocarboxylate transporter 1, Electrogenic sodium monocarboxylate cotransporter, Solute carrier family 5 member 8.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Restricted to the apical cell membrane of enterocytes.
Protein: OR1J2_HUMAN
Sequence: MSPENQSSVSEFLLLGLPIRPEQQAVFFTLFLGMYLTTVLGNLLIMLLIQLDSHLHTPMYFFLSHLALTDISFSSVTVPKMLMDMRTKYKSILYEECISQMYFFIFFTDLDSFLITSMAYDRYVAICHPLHYTVIMREELCVFLVAVSWILSCASSLSHTLLLTRLSFCAANTIPHVFCDLAALLKLSCSDIFLNELVMFTVGVVVITLPFMCILVSYGYIGATILRVPSTKGIHKALSTCGSHLSVVSLYYGSIFGQYLFPTVSSSIDKDVIVALMYTVVTPMLNPFIYSLRNRDMKEALGKLFSRATFFSW
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 1J2, HSA5, HTPCRX15, OST044, Olfactory receptor 1J3, Olfactory receptor 1J5, Olfactory receptor OR9-19.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL14_PARL1
Sequence: MIQQETNLEVADNSGARRVMCIKVLGGSKRKYASVGDIIVVSIKEAIPRGKVKKGDVMKAVVVRTAKDIRRADGSVIRFDRNAAVLINNQGEPIGTRIFGPVTRELRAKNHMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: Y1049_METJA
Sequence: MVIKKIIKKIRGNKDLPKPIEVPDEEYIVIGEEKPAYILEEESETESEVLGLEHKEKEEVKEVEEVVRVEKILPKLYVVRIKHPLDFENIKDKIPEYDVVIVNFEEVPFESILKELNEFRDYMSILNFKLGFVAENVLLAYRDDVILDKYVSNITDDAENV
What are the official names of this protein?
Uncharacterized protein MJ1049.
Protein: HSCA_BUCAI
Sequence: MIFFKKKHDKKLLLGIDLGTTYSLAATVREKSVILLLDKKKRYLLPSVVHYKKNKISVGWKALENITEDPTNTISSVKRLLGRSINFVKKKFPILPYLIEKDIHEGIFFRTNFGNITPIDVSSHILKKLKKRAVLLFNQEIDASVITVPAYFNDFQKKETKKAAVLSGINLIRLLNEPTAAAVAYGLQKLKKGIVLVYDLGGGTFDVSILNLNKGIFEVLATSGDSNLGGDDFDDALAKNIYKKSNLQNRCNDFFQTSLLQIAKSTKLKLTKYEKVEVHFFDWKGYITREEFNLIIIDFIKKTLFICSDLLEEINLSVEQIKEVIMVGGSTRIPLVHTEVSKFFKKDLLKSINPDQVVAIGAAMHVDMLFSSKNNTKNKVILLDVMPLSLGIEVMGGFVEKIIFRNTSLPISKTKEFTTYKDNQTSILIHIVQGERELVKDCISLSRFVLRDIKPQKAGLVRILVTFQVDTDGLIHVKILENYSSKEKKIIIDNNITLKNLNISQILKDSLKHSKDDYYFRVKEEKKIECVRTLEILNKSLKKHLKLISKKELKKIKYTQEKLQKSIQEDDYFSMKNNLQKLDEVSKNFFSLQLKNAIDCSSIKNILKENI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU (By similarity).
What are the official names of this protein?
Chaperone protein HscA.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CCD80_DANRE
Sequence: MRARYMLGFGVLCLLTWAVYVSESSPTDKQAKLRLMSVRRARQNKSRQGQIIKTRASSTWINDKRQQMQGDEGVQFRRNVQSRKVLAQRRPAQGGTRNPIQQDDGTPGARARVSRMPSSAGSPNLLASFAGKNRLLVISAPHDSDGYYRLMMSLLKPEVYCELAERHVHQIVMFHQEGELGGKIRRITNEGKVMEEPLDTALIPRLMTFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEVIDQSPMRKMEKVRQKGFVQKCKGAGVEGQVVEGVLTTDSQVDPPTERRKEIRKPIRRPTTTTTPAPTRPTTTTTTTKATTTTTTRPPTTTRSTTTTTTTTTTTTRPTTTTTRTTTTPRTTRANTTPQWIPAHKTTAEPYYYNRRDRYQTTSPPTDSARYRDNHTSKKEYNHRHTNTIPTQHKPTKVRPTKKKNGDKDISNAYEEKYDVGVPTDAYPEEKEEEIVPTKRGKGKTDKKKKKDKTDKLSKKDKAERRGKDGKGGKKNGKKVPKILEKEDYQKPTKRPPPPPPPKGTLATFLDYFESRRRLILITSPTEENSMYIQQRDEYLEHVCEMAIRKVTIITIFGTFRNSTMKIDHYQLEKDKPMKGLRQEDLENQDLIMELRKEYGMTYNDFYVVLTDLDMKAKQYYEVPIAMKAVFDYIDTFSSRIREMEQQKRDGVTCKKEDKPRSLENFLSRFRWRRRLFVISAPNDEEWAYQQQLYALTSQACNLGLRHVSVLKLVGTDLLDMGGVLELYPINGSATVEREGISATLVRDIRNYFQISPEYFSMLLVGKDGNVKSWYPSPMWSMAIIYDLIDSMQLRRQEMAIQQSLGMRCPEDEYGGYGYHHHEGYQEGYHQGYGY
What is the function of this protein?
Promotes cell adhesion and matrix assembly.
What are the official names of this protein?
Coiled-coil domain-containing protein 80.
What is the protein family that this protein belongs to?
Belongs to the CCDC80 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: BGAL_ECOL5
Sequence: MTMITDSLAVVLQRRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWRFAWFPAPEAVPESWLECDLPDADTVVVPSNWQMHGYDAPIYTNVTYPITVNPPFVPAENPTGCYSLTFNIDESWLQEGQTRIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFDLSAFLRAGENRLAVMVLRWSDGSYLEDQDMWRMSGIFRDVSLLHKPTTQISDFQVTTRFNDDFSRAVLEAEVQMYGELRDELRVTVSLWQGETQVASGTAPFGGEIIDERGGYADRVTLRLNVENPELWSAEIPNLYRAVVELHTADGTLIEAEACDVGFREVRIENGLLLLNGKPLLIRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMVPMNRLTDDPRWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPMYARVDEDQPFPAVPKWSIKKWLSLPGEMRPLILCEYAHAMGNSLGGFAKYWQAFRQYPRLQGGFVWDWVDQSLIKYDENGNPWSAYGGDFGDTPNDRQFCMNGLVFADRTPHPALTEAKHQQQFFQFRLSGRTIEVTSEYLFRHSDNEFLHWMVALDGKPLASGEVPLDVGPQGKQLIELPELPQPESAGQLWLTVRVVQPNATAWSEAGHISAWQQWRLAENLSVTLPSASHAIPQLTTSGTDFCIELGNKRWQFNRQSGFLSQMWIGDEKQLLTPLRDQFTRAPLDNDIGVSEATRIDPNAWVERWKAAGHYQAEAALLQCTADTLADAVLITTAHAWQHQGKTLFISRKTYRIDGHGEMVINVDVAVASDTPHPARVGLTCQLAQVAERVNWLGLGPQENYPDRLTAACFDRWDLPLSDMYTPYVFPSENGLRCGTRELNYGPHQWRGDFQFNISRYSQQQLMETSHRHLLHAEEGTWLNIDGFHMGIGGDDSWSPSVSAEFQLSAGHYHYQLVWCQK
What are the official names of this protein?
Beta-galactosidase, Beta-gal, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: COAA_YERPS
Sequence: MTKREQSLATPYLQFDRTQWAALRDSVPLTLTEEEIVKLKGINEDLSLDEVAQIYLPLSRLLNFYISSNLRRQAVLEQFLGTDGQRIPYVIGIAGSVAVGKSTTARLLQALLSRWPEHRSVELITTDGFLHPNKVLNERGLMKKKGFPESYDMHNLVKFVSEVKSGADYVTAPVYSHLIYDVVPDGNKVIKQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEDLLQSWYINRFLKFRQGAFSNPDSYFHNYAKLPETEAIKIATQLWNEINGLNLKQNILPTRERASLIMTKSANHAVESVRLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB8_RAT
Sequence: MALLDLCGAPRGQRPEWAAVDAGSGLRSDPGHYSFSVQAPELALPRGMQPTEFLRSFGDDQERKVQIEMAHGTTTLAFKFQHGVIVAVDSRASAGSYIATIRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVMDSGYRQDLSPEEAYDLARRAIVYATHRDSYSGGVVNMYHMKKDGWVKVESTDVSDLLHKYREATL
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.  This subunit is involved in antigen processing to generate class I binding peptides.  May participate in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity).  Required for adipocyte differentiation (By similarity).
What are the official names of this protein?
Proteasome subunit beta type-8, Macropain subunit C13, Multicatalytic endopeptidase complex subunit C13, Proteasome component C13, Proteasome subunit beta-5i.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: THIE_SYNS3
Sequence: MELMVVEADAKLRVARLIDANLDRAREGLRVIEDWCRFGLDRDDLVLPLKDWRQRLGQQHHDRYRRARSTATDVAAGLGHPAQTSRCSAPAIIKANASRVQEALRVLEEFGRNLDPDLASTAAEIRYGLYDLEVRILEACGRQHRQERLEGAKLCLITDPDRDNNLERLLHGVEAALMAGVSLVQYRRKQGNDKQRLLEAQALKTLCSRFEALFIVNDRIDLALLVDADGVHLGQDDLPLSEARQLLGPERLLGRSTHRLEHLLEAQQAGADYLGVGPVFATKTKRDLSPAGLSWVTEASRHAAVPWFAIGGIDIETIPSVRAAGAQRVAVVSAIMSSNDPEEASRTLLQTLA
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: RL27_SYNS3
Sequence: MAHKKGTGSTRNGRDSNSKRLGVKAYGGESVTAGSILIRQRGTSVMPGVNVGRGKDDTLFALTDGIVKFESIRRGLRNRKRITVAAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: CH60_CHLT2
Sequence: MVAKNIKYNEEARKKIQKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEVELADKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYTEGLRNVTAGANPMDLKRGIDKAVKVVVDQVKKISKPVQHHKEIAQVATISANNDAEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFATNPETQECVLEDALVLIYDKKISGIKDFLPVLQQVAESGRPLLIIAEDIEGEALATLVVNRIRGGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLISEELGMKLENANLAMLGKAKKVIVSKEDTTIVEGMGEKEALEARCESIKKQIEDSSSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALIRCIPTLEAFLPMLTNEDEQIGARIVLKALSAPLKQIAANAGKEGAIIFQQVMSRSANEGYDALRDAYTDMLEAGILDPAKVTRSALESAASVAGLLLTTEALIAEIPEEKPAAAPAMPGAGMDY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPLT_SALPK
Sequence: MSESVRTNTSIWSKGMLSVIVAQFLSAFGDNALLFATLALLKAQFYPDWSQPVLQMVFVGAYILFAPFVGQIADSFAKGRVMMVANGLKLAGAAGICLGVNPFVGYTLVGIGAAAYSPAKYGILGELTTGDKLVKANGLMEASTIAAILLGSVAGGVLADWHVIAALVACALAYAGAVAANLFIPKLVAARPGQSWRLSAMTRSFFSACVVLWRNGETRFSLVGTGLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAVGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVAIFSLQHALLPAYALLLLIGMLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGLYSLAVLVGVPAVAIGIGFGVLFALAIAALWIWQRRQASY
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTPRH_MOUSE
Sequence: MARAGGNCGVWRSLVLLGLYGCSVVRAAGTSVTVDRHAPASSYEFSMWVEKDGVSSSPQIPVTTAAPNPVRNLRVEGQNNISISLSWEPPDQSSLQGLTYWTQCSRHGGQTETRNTTDTSVTVDGLDPGSSYECSVWVEKDGLYSKNETLNTSTAPNPVRNLRVEGQNNISISLSWEPPDQPSLQGLTYWAQCSRHGGQTETRNTADTSVTVDGLDPGSSYECSVWVEKDGVYSTNETLNTSTAPNPVRNLRVEGQNNISISLSWEPPDQPSLQGLTYWAQCSRHGGQTETRNTTDTSITVDGLDPGSSYECSVWVEKDGVYSTNETLSNTTAPNPVRNLRVKSQNNFSISLSWEPPDQPSLQGLIYWAQCSRHGGQTETRNTTDTSVTVDGLDPGFLYKCSVWVEKDGVYSTNETLNTSTVPISASNPVRNLRVEGQNNFSISLSWEPPDQSSLQGLTYWAQCSRHGGQTETRNTADTSVTVDGLDPGSSYECSVWVEKDGVYSTNETLNTSTVPAAVNITSCISTSGGYGVLLTWSCPSGGYESFEVKVGRKWRSENGSLCGKGVTVSDLEPAQSYTATVTTVFKDLKAQSLSTTCHTESAAIIAGAIVGILLLFILVGLLIVFLKRRRKKRQPKEVPKDLVCSCPGDILAKDFADHVRENEKDSNCGFAEEYQQLALEGQGQSQITASALENRSKNRYRNVLPYDWSRVPLQPLQEEPGSDYINASFMPGLWSPKEFIATQGPLPNTVGDFWRMVWEQQSHTLVMLTNCMESGRVKCEHYWPLDAQPCIHGQLQVMLISEEASENWTVRHLQLFHMKEQQTLSLRQFHYLAWPDHGVPYSPDPLLAFRKMLRQWMDQTTDGGPPIVHCSAGVGRTGTLIALDVLLRQLECEGLVGPFSFVKKMRESRPLMVQTEAQYVFLHQCILKSLQKPAPALVPEEAMYENVASLVYENASAIMAHESEFSASGC
What is the function of this protein?
Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes.  Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway.  Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69.  Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70.  Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation.  Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC.  Reduces migratory activity of Jurkat cells (By similarity).  Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response (PubMed:26195794).
What are the official names of this protein?
Receptor-type tyrosine-protein phosphatase H, R-PTP-H, Stomach cancer-associated protein tyrosine phosphatase 1, SAP-1.
What are the subcellular locations of this protein?
Cell projection, microvillus membrane; Single-pass type I membrane protein. Cytoplasm. Apical cell membrane; Single-pass type I membrane protein. Note=Colocalizes with CEACAM20 at the apical brush border of intestinal cells.
Protein: ATG4A_CHICK
Sequence: MESEFPDTDEPVWILGRQHHLNEDKSKLLLDVSARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWQWEKHKKQPEEYHRILHCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCRSPPQSSSTAHSSAHLHRSALGRNRNAAGLCTGWKPLLLIIPLRLGINHINPVYIDAFKECFKMPQSLGALGGKPNNAYYFIGFLGNELIYLDPHTTQSFVDSEENGTVDDQSFHCQQAPHRMKIMNLDPSVALGFFCKEECDFDNWCSLVQKEILKQQSLRMFELVQKHPPHWPPFIPPTKPEVTTTGAELIESTDKLFELEEEFEILSV
What is the function of this protein?
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.  The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine.  Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy.  Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3.  In addition to the protease activity, also mediates delipidation of ATG8 family proteins.  Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy.
What are the official names of this protein?
Cysteine protease ATG4A, Autophagy-related protein 4 homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFPL3_HUMAN
Sequence: MKRLSLVTTNRLSPQGNFLPLCTFPLAVDMAALFQEASSCPVCSDYLEKPMSLECGCTVCLKCINSLQKEPHGEDLLCCCCSMVSQRNKIRPNRQLERLVSHIKELEPKLKKILQMNPRMRKFQVDMTLDADTANNFLLISDDLRSVRSGLITQNRQDLAERFDVSVCILGSPRFTCGRHYWEVDVGTSTEWDLGVCRESVHCKGKIQLTTELGFWTVSLRDGSRLSASTVPLTFLLVDRKLQRVGIFLDMGMQNVSFFDAESGSHVYTFRSVSAEEPLRPFLAPSIPPNGDQGVLSICPLMNSGTTDAPVRPGEAK
What is the function of this protein?
(Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.
What are the official names of this protein?
Ret finger protein-like 3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=A higher concentration of RFPL3 is observed in the cytoplasm compared to the nucleus.
Protein: DOIS_STREY
Sequence: MHVTAITMEDTSFPYRLGTECAEEIVARLGERAASRYLVVCDTTVAALYGRDLVARLEKDAGPAVLLTHPAGEVHKRIGTVGDLAEQALAAGADRRSVVVALGGGITGNIAGLLASLLFRGITLVHVPTTVVAMLDSVLSLKQAVNASFGKNLVGTFYQPAEVLADTAMLRTLPARELRSGMGEVVKNALAIRPSMIERLAAELRPDARYEDAAMRWIIEESVAAKAQVTGADKHERRDGLVLEYGHTTGHAIEHAARGEVAHGAGVAIGMIVAAEVSRLLGHASGDLVGLHRELVAKAGLEGSVPALVDPADVKHWLTYDNKRGYMPCPPAATPMVLLSAPGEVLRSGPLPLVPVPLELLGRAVDALAAPAGQSAGAERLSPAPA
What is the function of this protein?
Catalyzes the intramolecular carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose (DOI).
What are the official names of this protein?
2-deoxy-scyllo-inosose synthase, DOI synthase, DOIS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. DOI synthase family.
Protein: AAS_ECOBW
Sequence: MLFSFFRNLCRVLYRVRVTGDTQALKGERVLITPNHVSFIDGILLGLFLPVRPVFAVYTSISQQWYMRWLKSFIDFVPLDPTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQITLHILPPTQVAMPDAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTKTLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRMPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQVKQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTTNDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSVPGIEEGGRLQLKGPNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKVHATAIKSDASKGEALVLFTTDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEAEQHDE
What is the function of this protein?
Plays a role in lysophospholipid acylation.  Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium.  Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
What are the official names of this protein?
Bifunctional protein Aas.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COAE_PROMA
Sequence: MRVSKANALKRWKGSQRRIGITGGIASGKTSIGKYIESVKNTPILDADMFSREALTANQTIKDTIINRYGRTIVDKENTNSKTINRAALGEIIFHDKNERIWLENLLHPIIEKRFEEELEKHKLSSTIVLIIPLLFEANFTYLCSEVWLIYCSLDEQYERLMKRDGLNKEQAKYRIEAQLPLESKKILSDHIIDNTNKLDLSYPQVEVLL
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGMG3_BURCM
Sequence: MQPDPNPAAAPAALIELTGVSKRFPGVQALDDCRFDLRAGEVHALMGENGAGKSTLMKILAGVYQKDGGEIRMDGRAVEIDDPRAAQALGIGIIHQELNLMNHLSVAQNIFIGREPRGRFGVFVDEDKLNRDAAAIFARMRLDLDPRTLVGRLTVAKQQMVEIAKALSFDSRVLIMDEPTAALNNAEIAELFRIIGELRAHGVGIVYISHKMDELRQIADRVTVMRDGKYVATVPMAGTSMDAIIAMMVGRQLDTEFRTPPDTSANDVALEVRGLSRGRAIRDVGFTLRRGEILGFAGLMGAGRTEVARAVFGADPVDAGEIRVHGKTVTIRTPADAVAHGIGYLSEDRKHFGLAVGMDVQNNIALSSMRRFVRRGLFLDARQMRDTAQSYVRQLAIRTPSVAQPARLLSGGNQQKIVIAKWLLRDCDILFFDEPTRGIDVGAKSEIYKLLDALAAEGKAIVMISSELPEVLRMSHRILVMCEGRVTGELRAADATQEKIMQLATQRESTVLS
What is the function of this protein?
Part of an ABC transporter complex involved in carbohydrate import.  Could be involved in ribose, galactose and/or methyl galactoside import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Putative ribose/galactose/methyl galactoside import ATP-binding protein 3.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Carbohydrate importer 2 (CUT2) (TC 3.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ACEK_ECOUT
Sequence: MPRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKNRIHLYDHHVGLVVEQLRCITNGQSTDAAFLLRVKEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFHPDHGWESLLMRVISDLPLRLRWQNKSRDIHYIVRHLTETLGTDNLAESHLQVANELFYRNKAAWLVGKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLVYLQGCNEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDRFAPQKEMSAAHVRACYQLVKEHDRVGRMADTQEFENFVLEKRHISPALMELLLQEAAEKITDLGEQIVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPLPRYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQNRIREGHVEDVYAYRRRQRFSVRFV
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.