PharMolix/UniProtQA huggingface dataset:
Protein: RRP42_METMA
Sequence: MKKMSEIIATLKKDYIYNLMIKDKRQDGRGFKDFRELKLETNVISKAEGSAKVTLGNTQVLVGVKLQTGTPFPDSQDEGVIITNLELNPIASPEFEPGPPREDAIEMARVVDRGIRESGAIDIKKLCITVGESVWIVFIDVHILNNDGNIIDASCLAAIAALMTTMVPNEQQGLGENVPLAMKEMPVGITLAKIGSKLMVDPSLDEEAVCETKLTIVSSSDGSVAGMQKMGPVPLTEAELFEAIDMAIEKAAEIRGLYLEGLAKSE
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Contributes to the structuring of the Rrp41 active site.
What are the official names of this protein?
Exosome complex component Rrp42.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family. Rrp42 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_XANOM
Sequence: MSHPAYELPIDVNQIQALIPHRYPFLLIDRVIELDLEAKRIVGQKNVSINEPFFQGHFPTRPVMPGVLIIEALAQAGGVMTQLGLGRDALSKLFYMVKVDNARFNKQVVPGDVLILEVQMKRLIRNMGCYYGEAKVNGEIVASAEIMCAAARE
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_BRUC2
Sequence: MADLAKIVEDLSALTVLEAAELSKLLEEKWGVSAAAPVAVAAAGGAAPAAAAEEKTEFDVVLADGGANKINVIKEVRALTGLGLKEAKDLVEGAPKAVKEGASKDEAEKIKAQLEAAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: NSP3_ROTS4
Sequence: MLKMESTQQMAVSIINSSFEAAVVAATSALENMGIEYDYQDIYSRVKNKFDFVMDDSGVKNNLIGKAITIDQALNNKFGSAIRNRNWLADTSRPAKLDEDVNKLRMMLSSKGIDQKMRVLNACFSVKRIPGKSSSIIKCTKLMRDKLERGEVEVDDSFVDEKMEVDTIDWKSRYEQLEQRFESLKSRVNEKYNNWVLKARKMNENMHSLQNVISQQQAHIAELQVYNNKLERDLQNKIGSLTSSIEWYLRSMELDPEIKADIEQQINSIDAINPLHAFDDLESVIRNLISDYDKLFLMFKGLIQRCNYQYSFGCE
What is the function of this protein?
Plays an important role in stimulating the translation of viral mRNAs.  These mRNAs are capped but not polyadenylated, instead terminating in a conserved sequence 'GACC' at the 3' that is recognized by NSP3, which competes with host PABPC1 for EIF4G1 binding.  The interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1 interaction, thereby facilitating the initiation of capped mRNA translation.
What are the official names of this protein?
Non-structural protein 3, NSP3, NCVP4, Non-structural RNA-binding protein 34, NS34.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP3 family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: SYD_EXISA
Sequence: MIGRTHMNGRVTESLIGQEVQLKGWVQKRRDLGGLIFIDLRDRTGIVQVVVRPENEAVHQLAETIRSEYVLDVKGTVLERENKNPNMPTGNIEVIASEINILNAAKMTPIPIGDEAENVSEDLRLKYRYLDLRRPALQETFRLRSKTSNTIRNFLTEQEFLEVETPILTKSTPEGARDYLVPSRVHGGEFYALPQSPQLFKQLLMVAGFDRYFQIARCFRDEDLRADRQPEFTQVDIETSFMDIEDLMAMMESMMGQVMESTLGRTDTPAKFERMTHAEAMRRFGSDKPDTRFGLELIDVADAVKGAGFKVFDAALESNGQVKAINVKGEADNFSRKDIDKLQEFTAVYGAKGLAWLKVTAEGLNGPIAKFFDETYAQKLIEATNAEAGDLLLFVASKPTVVADSLGALRVKLGHELGLIDESKFNFLWVTDFPLVTFEEEDGRFYANHHPFTMPNREDLHLLETDPASVRAVAYDLVLNGYELGGGSQRIYERDIQERMFKLLGFTQEEAVEQFGFLLEAFEYGTPPHAGIALGLDRLVMILAGRSNLRDTIAFPKTASASCLLTQAPSPVADAQLEELSIRTAIKEKK
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRELP_BOVIN
Sequence: MRSSLCWLLTLLLILATAAQGQPTRRPRPRPRPRPRPRLRPTPSFPQPDEPTEPTDLPPPLPPGPPSVFPDCPRECYCPPDFPSALYCDSRNLRKVPVIPSRIHYLYLQNNFITELPVESFKNATGLRWINLDNNRIRKVDQRVLEKLPSLVFLYLEKNQLEEVPAALPRNLEQLRLSQNQISRIPPGVFSKLENLLLLDLQHNKLSDGVFKPDTFQGLKNLMQLNLAHNTLRKMPPKVPSAIHQLYLDSNRIEAIPSGYFKGFPNLAFIRLNYNQLSDRGLPKNSFNISNLLVLHLSHNRISSVPAISSRLEHLYLNNNSIEKINGTQICPNNIVAFHDFSSDLEHVPHLRYLRLDGNYLKPPIPLDLMMCFRLLQSVVI
What is the function of this protein?
May anchor basement membranes to the underlying connective tissue.
What are the official names of this protein?
Prolargin, Proline-arginine-rich end leucine-rich repeat protein.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: CYB_NYCBE
Sequence: MTNIRKNHPLMKIINHSFIDLPAPSNISSWWNFGSLLGLCLTIQIVTGLFLAMHYTSDTTTAFSSVAHICRDVSYGWIIRYIHANGASMFFFCLFIHIGRGLYYGSFTLLDTWNIGIMLLIAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWVWGGFSVDKATLTRFFAFHFILPFIVAALVVIHLIFLHETGSNNPSGISLDSDKIPFHPYYSLKDLLGVVFLLATLSILVLFSPDLLGDPDNYTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAMSILILALIPHLHTAKQRSMMFRPLSQCLFWVLVANLLTLTWIGGQPVENPFIIIGQTASILYFLTILILMPLTSLFENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LEU3_XYLFT
Sequence: MSKKILILPGDGIGHEIVAEAVKVLEHVNVRHTLNMRLSFDALGGAAYEKYGSPLADETLARAREADAVLLGAVGGPQWDTIDPALRPERGLLKIRAQLGLFANLRPALLYPQLADASTLKPEVVAGLDILIVRELTGGLYFGQPRGSRISKNGEREAFDTLPYCESEIRRILKVGFEMARLRGKKLCSVDKANVLASSQLWRTVAGEMAKDYPDVTLSHMYVDNAAMQLVRYPKQFDVIVTENMFGDILSDQASMLTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGQGVANPLATILSVAMLLRYGMGYIKTADAIEYAVGVVLDSGLRTADIWSEGMTKVGTVAMGDAVVAAL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AA3R_RABIT
Sequence: MPDNSTTLFLAIRASYIVFEIVIGVCAVVGNVLVIWVIKLNPSLKTTTFYFIFSLALADIAVGFLVMPLAIVISLGITIGFYSCLVMSCLLLVFTHASIMSLLAIAVDRYLRVKLTVRYRRVTTQRRIWLALGLCWVVSLLVGFTPMFGWNMKPTLESARNYSDFQCKFDSVIPMEYMVFFSFFTWILIPLLLMCALYVYIFYIIRNKLVQSFSSFKETGAFYRREFKTAKSLFLVLALFAGCWLPLSIINCVTYFKCKVPDVVLLVGILLSHANSMMNPIVYACKIQKFKETYLLIFKARVTCQPSDSLDPSSEQNSE
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.
What are the official names of this protein?
Adenosine receptor A3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PUR5_GLOC7
Sequence: MDYKEAGVDVEAGRNFVEKIKKKVESTHRPEVLGGLGGFGGFFQIPSGYQEPVLVSGTDGVGTKLKLAQGLNCHHTVGIDLVAMCVNDVLTSGAQPLFFLDYLATGQLNPQQLAEVVEGIVEGCHLSHCALLGGETAEMPGFYGVGEYDLAGFCVGIVEKSLLLDGSQVQIGDAVIGLASSGVHSNGFSLVRKIVETQGLSWDFCPDILEGKSLGEVLLTPTQIYVKPILEALSSNLKIHGMAHITGGGLPENLPRCLQANQSVQINPNSWEILPIFTWLAQAGQVSPSAMFNTFNMGIGFVVIVPVDQAETTLNWFNNKGIKAYQMGEVIEGTGHLVGLDF
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GANA_ASPFC
Sequence: MLGKTVLLPLLVLLCHSLASASLVYRGADISSLLIEEKAGIEYKNVNGQTQPLENILKANGVNSVRQRVWVNPSDGSYNLDYNVKLAKRVKAAGMSVYLDLHFSDTWADPSHQTTPRGWSTNDIGTLTWQVYNYTMEVCNTFASNGIDVSIVAIGNEIRNGLLWPLGKPDNYANIANILHSAAFGVKDSTLSPKPKIMIHLDNGWDWSAQKFFYDRVLSSGANLVKSDFDLIGVSYYPFYNPSATLSALTTSLKNLRSTYGKDVLVVETDWPVLCPNPAYAFPSDLKDIPFSVAGQTTFVQRVANIVAQTPGGIGLYYWEPAWVQNAALGSSCADNLMVDWSTRQARTSLSVFATI
What is the function of this protein?
Endogalactanase involved in the degradation of plant cell wall polysaccharides, and more particularly of hairy regions of pectin.
What are the official names of this protein?
Probable arabinogalactan endo-beta-1,4-galactanase A, Endo-1,4-beta-galactanase A, Galactanase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 53 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YTA12_SCHPO
Sequence: MRNPFLTFRAPTRKTGDYLVSKFVKKDNFSSLRLARAYTFSTRSTAVSQFSLLSLSQRSFQSLKINKGIPEKHKIPLISSKQFSVTSKRSQNGSSGSNSDANGRKNGQKNDDSKKKGLNGNDPKKVFEIALNGNTILGGILVAYILYNVLSPNANMQEITWQDFRQQFLDKGLVERLVVVNRNMVRVILRGGVASGSGQYYFSIGSIDSFDRKLEDAQRQLGIPPSEFVPVAYHDEVSVLATLLSFAPTLLIIGSVIYLSRRASGAAGGGQGGIFGIGKSRAKMFNHETDIKIKFADVAGVDEAKEEIMEFVKFLKNPKFYERLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPFLSVSGSEFLEMFVGVGPSRVRDLFATARKNAPCIIFIDEIDAIGKARGRGGQFGSNDERESTLNQLLVEMDGFTSSEHIVVFAGTNRPDVLDPALLRPGRFDRQITIDRPDIGGREQIFKVHLKHIKAADNIDLIAKRLAVLTSGFTGADIMNVCNEGALIAARSNSNEVQMVHFEQAIERVTAGLEKKSRVLSPEEKNTVAHHEAGHAVAGWFMEYVDPLLKVSIIPRAQALGYASYLPKDQYLMSRGQILDQMGMALAGRVSEEIFFGPEKITSGASDDFQKVTRMAQAYVTQYGMSPTVGTIAYPIDTRETVQKPFSEATAQMIDEEIRKLVKHAYERTKKLLLEHKQGLENIAQRLLQKEVITYNEVETILGPRPYAYKHLNISELMRQSEYKNDHDPRNPPIPPSPQQPSA
What is the function of this protein?
Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins.  The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes.  Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides (By similarity).
What are the official names of this protein?
Mitochondrial respiratory chain complexes assembly protein rca1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: MUTS_BORGP
Sequence: MEKNITPMMRQYLDIKKKYKDAIIFFRVGSFYEMFFDDAIEASKLLNLTLTKRENVPMCGVPYHTSKEYIRKLILFDKKVAICEQASNLTSTGPLEREVVEVITPGVIVDEDFLNDDVNNYLVAISDYKNYYSFSYIDLSTSSLGVMFYENSFFEKLKRDLEKYSPKEIIVSENFYYQYLHKLNLSRFLINRVPAWHLDKDIAIKTIKEHFNILGLSSLGFDEEKPYYISIFLIINHIKNNLKNLLSNIDKIDINNDSSYMFLDDVTQVNLELVKNNNDFSSQYSLYSVLNDCKTAMGKRLLREFILNPILNISEINTRLDHVEFFYKNISLTMTLREAFINIWDIERIISRIQMKRYIKKDFLFIEKALSVFFLVKKLFDKHNFDYWNFDKFEEDSVSKVYFLINSAISDSSDELIKRGYDLKLDNLKDLKINANKYIDEYLESERILSKINNLKIRKTNNRGLFFEVTKSNYSQVPSHFMESQTLSSSKRYKTEKLISLEVDINNAEDSVVAFEQEIFDEIAANVVKHNKVLKKVAEFFAYIDLVVNFGYLAKKNEYKRPVLTSDKEIFLDKSRHPVVEHYVKNAEIFTENFVRINKERHFCLITGPNMAGKSTYLRQVALITLMAHIGSFVPASKALIGITDKIFCRIGASDNLAKGESTFLVEMNETANILRNATEKSLIIMDEVGRGTSTNDGLAIAYSIIEYILEYIKARSLFATHFHELSAINHKAFINLSMKIEKQGNDLVFLREIEEKPSLNSYGIYVARIAGLPLKVIDRANAILESLLSRKGSSFLEFLPYISSDSNDKEALKNDTDVNVKLNEYLELKNFISNIDINNITPFQSIELLNQIVLKVISQSS
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RHAD_ECO5E
Sequence: MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIALYHDNFHPQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGVVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAEVLVKVYSMGGMKQTISREELIALGQRFGVTPLASALAL
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_ECOSE
Sequence: MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: FTSQ_MYCA9
Sequence: MSEPENTAEDKDAEAAISADAVESETTADGGENPAEGESAEGPRMRARRERMERREAQRRAIALEQARREAKAAAKGKYVEQGKGAGRGKVQGLQTLLLVVLLALIAVGLGSILYFTPLMSVRQTVVTGTGVVTQEDVLGALSIPKGTRLLQIDTAAAADRVASIRRVASARVQCEYPSTLRVTIVERVPVAAWTGADGTHLIDRDGVDFANEPPPPGIPALDVVAPAPQDPTTKAALQVLTSLAPDLARQVAKIAAPSVSSITLTLDDGRTIVWGTTERTAEKAEKLGALLTQPGRTYDVSSPDLPTVK
What is the function of this protein?
Essential cell division protein.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: UCPA_ECOLI
Sequence: MGKLTGKTALITGALQGIGEGIARTFARHGANLILLDISPEIEKLADELCGRGHRCTAVVADVRDPASVAAAIKRAKEKEGRIDILVNNAGVCRLGSFLDMSDDDRDFHIDINIKGVWNVTKAVLPEMIARKDGRIVMMSSVTGDMVADPGETAYALTKAAIVGLTKSLAVEYAQSGIRVNAICPGYVRTPMAESIARQSNPEDPESVLTEMAKAIPMRRLADPLEVGELAAFLASDESSYLTGTQNVIDGGSTLPETVSVGI
What are the official names of this protein?
Oxidoreductase UcpA.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: YUXJ_BACSU
Sequence: MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGITFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLVTGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFITSFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTGNFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIGLLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGYNVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS
What are the official names of this protein?
Uncharacterized MFS-type transporter YuxJ, ORF1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BTUC_SHIF8
Sequence: MLTLTRQQQRQNIRWLLCLSVLMLLALLLSLCAGEQWISPGDWFTPRGELFVWQIRLPRMLAVLLVGAALAISGAVMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPNWALGLCAIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSALMTWAIYFSTSVDLRQLMYWMMGGFGGVDWRQSWLMLALIPVLLWICCQSRPMNMLALGEISARQLGLPMWFWRNVLVAATGWMVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASALLLADIVARLALAAAELPIGVVTATLGAPVFIWLLLKAGR
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Involved in the translocation of the substrate across the membrane.
What are the official names of this protein?
Vitamin B12 import system permease protein BtuC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: METL8_HUMAN
Sequence: MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAAARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTLFI
What is the function of this protein?
Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) (PubMed:34774131, PubMed:35017528).  N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain (PubMed:34774131, PubMed:35017528).  N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite (PubMed:34774131, PubMed:35017528).  May also mediate N(3)-methylcytidine modification of mRNAs (PubMed:28655767).  The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo (PubMed:34774131, PubMed:33313824).
What are the official names of this protein?
tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial, Methyltransferase-like protein 8, mRNA N(3)-methylcytidine methyltransferase METTL8.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METL family.
Protein: Y1293_METJA
Sequence: MTNKTRKETNEIKNNITLPPNIKTEVNRTSKYDFTNLSKDLEIVYALIKITGFDEYLPFNIENLNKIFIKEKISPYPYLLNLIKDLIILFVIGLIITIIGLLMYEPTRPKVISIIASILYKLKIKEKPKPKKKETIKLPKPPKIYISDVIYSLGDTVRIEISSEIDIGNNLYILSPTNKKYKIELIKTGKNKYLGLFKIPENEVPGQYFIIYKPENLSIGGFLVVDIKKEM
What are the official names of this protein?
Uncharacterized protein MJ1293.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SYA_CLOD6
Sequence: MEKMGLNEIRSKFLEFFESKGHYVANSYSLVPNNDKSLLLINSGMAPLKNYFSGVEVPPSVRMCTSQKCIRTGDIENVGITARHATFFEMMGNFSFGDYFKRESIKWGWEFVTEWLNIPEDKIWVTVYEEDDDSYDIWAKEMNFPEERMVRLGKDDNFWEIGTGPCGPCSEIYFDRGEEYGCDNPDCKPGCDCDRYLEFWNHVFTQFDRDEEGNYSLLENKNIDTGMGLERMGCIMQGVDTIFEVDTIKSILEAVEKLTGVKYGENPKNDISIRIITDHIRAVTFLVSDGVLPSNEGRGYVLRRLLRRAARHGKLLGVKELFLQKLIDEVIKVNDKAYPVLVEKESYIKKVVGIEEEKFNETIDQGTEILNSYIEVLKNEGKTVLSGQEAFKLYDTYGFPIDLTKEILEEEHLSVDEEAFNEEMEKQKERARNARGNMDGESWKEDPLSKLESTVDSTFNGYSEIYGEGTIEAIVKDDELVQSAEEGDKVSIVLDNTTFYPEGGGQVGDCGLITNENLVLEVLNTKKGANNSIKHIGIIKSGRISNGDKVKTLVDRETRMSAARNHSATHLLHKALREVLGEHVNQAGSLVTPERLRFDITHFEAISNEELKVIEEKVNNVILSSLDIKCDIMNIKEAKEKGATALFGEKYGDEVRVVSMGDYSTELCGGTHLTNTSQVGMFKILSEGGVAAGVRRIEAITGKAVYEYLKERDGIISEVCVNLKSKEDNLIQRISSLLEENKNLSKELHDMKAKMSLQSVDSIFDSKVEVNGVNLITNKFEGMDMDTLRETADNLRDKLGSGVVVLANVVDDKVNFVVTATKDVLDKGIHSGNIVREVAKIAGGKGGGRPNMAQAGASDVSKVDQALSYASEVIKTQVK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACYP_SYNSC
Sequence: MIEGRVQRVGFRASCNRRALDLGISGWVRNLSDGRVEVQAEGPPLALSELRAWCEVGPPGARVVRVTPSQLPITGDDWFEVRY
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: MIAB_DEIRA
Sequence: MGQKAKAQAPTTHPRPHTLSSQVAPALPRRPRHAAPESLRQARGEVMKAHLITYGCQMNEYDTHLVQSQLVSFGADIVESPDEADFVLVNTCAVRGKPVDKVRSLLGDLRKQKAQRSLVVGMMGCLAQLEEGQQIARKFEVDVLLGPGSLLDIGAALESNERFWGLQFKDELHDHIPPPPSGKLQAHLTIMRGCDHHCTYCIVPTTRGPQVSRHPDDILRELDMQLAAGVREVTLLGQNVNAYGVDQGAKLKGYPSFADLLRMVGASGIERVKFTTSHPMNFTEDVAAAIGETPAICEFVHLPVQSGSDRVLRRMAREYNREKYLTHIAQIKKHIPDVVLATDIIVGFPGETEEDFQDTLSLYDEVGYDSAYMFIYSPRPGTPSYKHFQDLPRELKTERLQRLIARQKDWSARKNAQKVGTVQQVLLRGDAHDAGFLEGHTRGNHPTVVPKAIGADGAGVYQVRIDHATPHMMYGHILGPDGQPLPEQPRFNPEAAAVGGALPML
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_MOUSE
Sequence: MAGPRPVVLSGPSGAGKSTLLKKLFQEHSSIFGFSVSHTTRNPRPGEEDGKDYYFVTREMMQRDIAAGDFIEHAEFSGNLYGTSKEAVRAVQAMNRICVLDVDLQGVRSIKKTDLCPIYIFVQPPSLDVLEQRLRLRNTETEESLAKRLAAARTDMESSKEPGLFDLVIINDDLDKAYATLKQALSEEIKKAQGTGHA
What is the function of this protein?
Catalyzes the phosphorylation of GMP to GDP.  Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:8663313).  Involved in the cGMP metabolism in photoreceptors (By similarity).
What are the official names of this protein?
Guanylate kinase, GMP kinase, Guanylate kinase 1.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Photoreceptor inner segment. Cytoplasm, cytosol. Note=Colocalizes with RD3 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer.