PharMolix/UniProtQA huggingface dataset:
Protein: PSRP_AZOVD
Sequence: MKRTAFFISDGTGITAETLGQSLLAQFENISFTKLTRPYIDTAEKARGMVQQINAAAERDGARPIIFDTVVNQEIRDILAKSNGFMIDIFSTFLAPLEHELISHSSYSVGKSHSISHNAHYMERIEAVNFALDNDDGARTHYYDKADLILVGVSRSGKTPTCLYMAMQYGIRAANYPLTEEDMERLQLPTALKPYREKLFGLTIDSERLAAIRHERKPNSRYSSFSQCEFEVRETEKLLRREKIPFINSTHFSVEEISAKILVEKGVERRLK
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: EFTS_SYNS3
Sequence: MAAVSAKLVKELRDKTGAGMMDCKKALAETSGDTTKAVEWLRQKGIASAEKKSSRAAAEGAIGSYIHTGARVGVLLELNCETDFVARGDLFQGLLRDVSMQVAACPNVEYVSTDDIPQDIIDREKSIEMGRDDLDGKPDQMKVKIVEGRIGKRLKEMSLLDQPFIRDSSMSVADLVKEVAGKIGENVKVRRFTRYTLGEGIEIKQVDFATEVASMTNS
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUUC_ECOLI
Sequence: MNFHHLAYWQDKALSLAIENRLFINGEYTAAAENETFETVDPVTQAPLAKIARGKSVDIDRAMSAARGVFERGDWSLSSPAKRKAVLNKLADLMEAHAEELALLETLDTGKPIRHSLRDDIPGAARAIRWYAEAIDKVYGEVATTSSHELAMIVREPVGVIAAIVPWNFPLLLTCWKLGPALAAGNSVILKPSEKSPLSAIRLAGLAKEAGLPDGVLNVVTGFGHEAGQALSRHNDIDAIAFTGSTRTGKQLLKDAGDSNMKRVWLEAGGKSANIVFADCPDLQQAASATAAGIFYNQGQVCIAGTRLLLEESIADEFLALLKQQAQNWQPGHPLDPATTMGTLIDCAHADSVHSFIREGESKGQLLLDGRNAGLAAAIGPTIFVDVDPNASLSREEIFGPVLVVTRFTSEEQALQLANDSQYGLGAAVWTRDLSRAHRMSRRLKAGSVFVNNYNDGDMTVPFGGYKQSGNGRDKSLHALEKFTELKTIWISLEA
What is the function of this protein?
Catalyzes the oxidation of 3-hydroxypropionaldehyde (3-HPA) to 3-hydroxypropionic acid (3-HP) (PubMed:18668238).  It acts preferentially with NAD but can also use NADP (PubMed:18668238).  3-HPA appears to be the most suitable substrate for PuuC followed by isovaleraldehyde, propionaldehyde, butyraldehyde, and valeraldehyde (PubMed:18668238).  It might play a role in propionate and/or acetic acid metabolisms (PubMed:18668238).  Also involved in the breakdown of putrescine through the oxidation of gamma-Glu-gamma-aminobutyraldehyde to gamma-Glu-gamma-aminobutyrate (gamma-Glu-GABA) (PubMed:15590624).
What are the official names of this protein?
NADP/NAD-dependent aldehyde dehydrogenase PuuC, ALDH, 3-hydroxypropionaldehyde dehydrogenase, Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase, Gamma-Glu-gamma-aminobutyraldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: Y942_METJA
Sequence: MEFKGYIKEKFPYPKVREPQKRMMLKIYECIKNKRNLIVEAPTGVGKTLGYLIPALYFAERRKRVLILTETIDQQVRIYEDLSSLRHNLKVAFLMGKSNFICKSKGGKANRLYCQLNKKCLYRPNKRPICYCGTKKQPVNLGDKVIYYCPYCTCEYQKAKIESILADIVVMNNSMFYYAKEDIEAKRDIDIIICDEAHKLESSIRNTSTIIINPELPINRLKYMAIHYAPNILKKRLDIGDENFWEIIEKYLTSRGINIDICKETIIFDGENLSSWKYKTELAVLGAILDAYYQINNIKNKILRFNENEEIDREELRFEIDNKALIAIELDFIHKKKLSDLYLLEFIENIKNLRYINENYVVYRSGNSLLCEPVFVSSHLKELYGNAVVIHCSATIGNLKMHALKTGLDKAEFLILESPFPKNRKKIIALKDGVDMKYERKDREKANKNLLKILEAINGNSLVLFKSFEDLDSFYKYLKREITKTNIKNKNIHVYEQGMDGKEAKELKERFEKIGGILLATGRFAEGVDIPGEALVGVVIDSLPFPVPTPLILREQKILEERFKIRGVRDAHWRAFLMTSFDRMARTLVQMIGRLIRTENDYGVVVIQDKRFADWVGRVMREKGYLKDNYEVMSLDMAIKYIPKFMSQFKN
What are the official names of this protein?
Probable ATP-dependent helicase MJ0942.
What is the protein family that this protein belongs to?
Belongs to the helicase family. DinG subfamily.
Protein: SYFA_BURVG
Sequence: MDLDQIVADAQQSFEQAADITTLENEKARFLGKSGALTELLKGLGKLDPEARKTEGARINVAKQQVEAALTARRQALADALLNQRLAAEAIDVTLPGRGAGAGSLHPVMRTWERVEQIFRSIGFDVADGPEIETDWYNFTSLNSPENHPARSMQDTFYVEGKDADGRQLLLRTHTSPMQVRYARMNRPPIKVIAPGRTYRVDSDATHSPMFNQVEGLWIDENISFADLKGVYTDFLKKFFERDDILVRFRPSYFPFTEPSAEIDMMFEHGKNAGKWLEISGSGQVHPTVIRNMGLDPERYIGFAFGSGLERLTMLRYGVQDLRLFFENDLRFLRQFA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREG_ACIAD
Sequence: MTERSPLRVGIGGPVGSGKTALTLNLCRALRNKYNMAVVTNDIYTKEDSNFLTRNEAMTPDRIVGVETGGCPHTAIREDASINLAAIDDLCEKFDGLELIIIESGGDNLAATFSPELSDLTLYVIDVAGGEKIPRKGGPGITKSDLLIINKTDLAPMVGANLDVMEQDAKRMRGEKPFLFSNMKTEDGLTQIIEFIEKQGLFKA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MALE_THELN
Sequence: MNVKKVLLGLFLVGVLGIAVVASGCIGGQQTSTVTSTPTETSLQGKIVFAVGGAPNEIEYWKGVIAEFEKKYPGVTVELKRQATDTEQRRLDLVNALRGKSSDPDVFLMDVAWLGQFIASGWLEPLDDYVQKDNYDLSVFFQSVINLADKQGGKLYALPVYIDAGLLYYRKDLLEKYGYSKPPETWQELVEMAQKIQSGERETNPNFWGFVWQGKQYESLVCDFVEYVYSNGGSLGEFKDGKWVPTLNKPENVEALQFMVDLIHKYKISPPNTYTEMTEEPVRLMFQQGNAAFERNWPYAWGLHNADDSPVKGKVGVAPLPHFPGHKSAATLGGWHIGISKYSDNKALAWEFVKFVESYSVQKGFAMNLGWNPGRVDVYDDPAVVSKSPHLKELRAVFENAVPRPIVPYYPQLSEIIQKYVNSALAGKISPQEALDKAQKEAEELVKQYS
What is the function of this protein?
Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import.  Binds maltose and trehalose.
What are the official names of this protein?
Trehalose/maltose-binding protein MalE, TMBP.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: KAD_CHLTR
Sequence: MDRSPLFLIIMGAPGSGKGTQSKLLASQLSLLHISSGDLLRDAVSKDTPLSQEIKSYLDQGKLLPDTLVWKLVHEKLDEFQQDTLLRRLSFLSRSENSAILDGFPRTVTQAKLLHEFLSSYFPNYKVILLDISDEEVLNRLTSRYICPACQGIYNEQQGFSSCPKCSVELIRRSDDTLEVILDRIQTYKQETQPVLDYYTEKQKLITIDANAPTQQVFQSILDSLSASLVYQERDCCNCDCDDED
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_DEIRA
Sequence: MAFRDVLNIEVAAGNGGDGSMSFHRAKYMEKGGPDGGHGGRGGSIILRAIEGVESLERLVGRRKFKAENGRYGEGRLRQGADGQDTYIDVPVGTTAFDEDSGKVIADLVNVGQEKVIAKGGLGGRGNSTFTSSTRQAPRFAELGTPGQKRRVRLELRLIADVGLVGYPNAGKSSLLAALSRANPAIADYPFTTLSPILGVVQREDEQGVSLDERFTMADIPGIIEGASEGKGLGLEFLRHISRTRLLVYVLDVTRNPVEELQQLQAELRAYDPSLLDNVALVALNKVELVEPDLAQMVEDELAEQGLPVLQVSAKEGTGLNTLRETLFQLLPEFELWAQSNALEVEPDTVVDEALQIVFREDAPAKGEGAPERVWEVHGGGFEERIVRFSRYLEDAAEYLGNLFKRQGLYNALRRAGAREGDTVEIGTFRFEYFDDEE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAND_CAUVC
Sequence: MLLTMLKAKLHRATVTQADLDYEGSIAIDRDLLDASGILPNEQVDVLNITNGARFTTYAIEAPRGSKVIGVNGAAARLVQKNDLVIVVTYCQMPAEEARNYAPTVVLLDEGNLIKKAA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUFE_YERPS
Sequence: MAGLPDRDKLIRNFSRCLNWEEKYLYIIELGGQLAPLTEQQRHPENLISGCQSQVWIAMTLSAEGHVIFAGDSDAAIVKGLVAVVFILYHDLTPQQIISLDVRPFFADLALSQHLTPSRSQGLEAMIRAIRTKVANLSAH
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FB236_ARATH
Sequence: MEEEEKNPSSIYIVADLLEDIFLRLPLKSILISKSVSKRWRSILESKTFVERRMSLQKKRKILAAYNCKCGWEPRLLPGSSQCKGNEEIVYLHCNAAQPSFTCDGLVCILEPRWIDVLNPWTRQLRRYGFGFGTIFGVGSAFSPRHWAMGFGKDKVTGSYKVVKMCLISFSEICARDPEVEYSVLDVETGEWRMLSPPPYKVFEVRKSECANGSIYWLHKPTERAWTILALDLHKEELHNISVPDMSVTQETFQIVNLEDRLAIANTYTKTEWKLEIWSMDTEVETWTKTYSIDLENRVASRERRNRWFTPVSVSKQGNIVFYDNHKRLFKYYPRKNEILYLSADTCVISPFFENLAPLPQKSTLHTPIIAGEPNAPLTTLVVVGSIWSPLFLFSVKL
What are the official names of this protein?
Putative F-box protein At4g17780.
Protein: SELU_ECOLI
Sequence: MQERHTEQDYRALLIADTPIIDVRAPIEFEHGAMPAAINLPLMNNDERAAVGTCYKQQGSDAALALGHKLVAGEIRQQRMDAWRAACLQNPQGILCCARGGQRSHIVQSWLHAAGIDYPLVEGGYKALRQTAIQATIELAQKPIVLIGGCTGSGKTLLVQQQPNGVDLEGLARHRGSAFGRTLQPQLSQASFENLLAAEMLKTDARQNLRLWVLEDESRMIGSNHLPECLRERMTQAAIAVVEDPFEIRLERLNEEYFLRMHHDFTHAYGDEQGWQEYCEYLHHGLSAIKRRLGLQRYNELAARLDAALTTQLTTGSTDGHLAWLVPLLEEYYDPMYRYQLEKKAEKVVFRGEWAEVAEWVKAR
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln) (PubMed:14594807, PubMed:22983156, PubMed:24971911, PubMed:29862510).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA) (PubMed:14594807, PubMed:24971911, PubMed:29862510).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain (PubMed:24971911, PubMed:29862510).
What are the official names of this protein?
tRNA 2-selenouridine synthase, Selenophosphate-dependent tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: RS15_SYNFM
Sequence: MVMTPEKKKEIIEGFKVHSADTGSPEVQIALLSERISYLTEHFKMHKKDHHSRRGLLKLVGQRRQLLNYLKKKNAERYNNVIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RRF_PECCP
Sequence: MTNEIRKDAETRMDKCVEAFKNQISKIRTGRASPSILDGIQVEYYGSATPLRQVANVVVEDSRTLAITVFDRTLGPAVEKAIMASDLGLNPSSAGTVIRVPLPPLTEERRKDLIKVVRGEAEQGRVSVRNVRRDANDKLKALLKDKAISEDEERRAQDDVQKLTDNFIKKVDTALAEKEAELMEF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPTD_FRAT1
Sequence: MLKGIHKYLLMCFGTVLFTVQANAARIMSNNPIKEDWQCKVVDGEWSCKRAKKPKSVFDKKLTKTEKEKALADDLAWVKKPSYFVGGYYSNDNQFTKALCESKKTDLSYEKSEFDNYGTLIASGNVQVLQCDQELYGNNAIINLNSNNSAIRSLVMAGDVIVKQPSTGIVIRTTELDADMNNGTYSTGEAYFRLAREMPKTRIYDKEHFSGYLRGYAKTFKKESSGDIVLSDGYITSGDPYDNAWKITGNNIDIDTNTHMAYVKNGYFEIQDIPVMYIPYFSHPIDDRRRSGFLYPGFVQNANSGIGISVPYYFNLAPNYDLMLQSVIWSQRGIIENGTFRYMTKYFQGQFEGSLVPYDFKEGKMRGSFTLSTTGQYENINTNFKYEYVSDQNYYNDFSAGNVNLVTKTLLDREFDLTYTNDYVDSGLTVLDYGVVNPLLTVDNTPYAKLPEVKLNLTSDGYTPDYLTLSAQTLNTFFYKTAGPANTNPGAPQGTNVNAFRAYESPKIAFNFNKTWGYLNPSLEVPIRYYQLKNSPTDTIQFANSSVTSVLPIFNIDAGAYFDKDYTNENGTYTSTLHPRLFYTYIPYQDQTNIPLFDTSLQNEQYMQMFQVNRFTGYDRINNANQLTYAIEASTTNQDNGTTLASAKIGQMAYFADRKVNLCQGNSACPNPGLMDPFSTDTFSPIMSSFEFQVMKNIYLSAQVNYRVNQQNVDYQVYQLSYKDENENIFNVSYNNIANNWNSLTQQQIAEGAKPQPQETITLSTVLNITDHWGIAALWNYNFQQKQIANIFAGLQYNAKSWAVRALWQKTAYTNQDPNNPTLLGPLVNTYMFEFELKGLGGIGNTSDISSRLQQINGYQVGEWGNGI
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: PWP2_CAEEL
Sequence: MDTNFKLSNCIGTVYRDGQVAFSKDGYSVISPIGNKLSIFDLRNNTSKTLDIDCNYNIKRLSISPSGYHLLASDERGVVHFVHLLSEFKIYTFRSNKPIGSLQWSPDATRVAICRENDLQIHEFGKSIENKVYNPFSLSRTYKLSSDSLKTIDWSDDANLLVSGGEDRVVRVVGAKDFKNLFIHPLASHKGYIVNCQFMKNSYDMITVCKRGLANVWTCNLRPGELVEGIWKKDEEGSDDIEMLEDGEQKVEKIFFEKTKKYWLSESSGSGKSVDVTAARFHKETNILATAFNNGVIVLHEIPSFALVHNLRVSEMRIQTVAWNLTGDWLAIGCGKGSTAQLVVWEWQSESYVMKQQAHSLRITTAEYSPDGSLMATGAEDGKVKIWNSRSSFCTVTFDEHTSGVTAVKWTQSGRAILSASLDGTVRAHDLKRYRNFRTLVCPEPTQLATLAVDKAGDLVIAGAKEVFNIYIWSFETGHLLDILSGHESAISSIDIHGNHIVSGSWDRTIKMWTIVDSQAETVEVSHEALDVKFSPAGDEIAVLTSDGVITFFEAKEMINLGSIDTKLDTDPARGSRDTITRQSAAKTKTFTRIRFSPDGNLLLAGGESNNFCLYSVPERMILKKWQITANRSLDGVILDFNRRNFTEFGNMQLVDTSDEEDELEPNNKMSIKLPGTKNFDLGERRARPEVNIYEVTYCPTGRRFAICSTEGVSVYSLDTISMFDPFQLDSQTNAEVIKRAVWNNDYSTAIMASLRLNNAQYITECLESTSISQIPLVASSLPLMYAERLLKWMVEGNVMSSTRHVHFYMIWLRAILQHHGMQLKGRADVATLTGIQQIVAHHQQHITKLANQNKFALNWLVKIRQSKKSVKKEEEEEEDVSDESDDEDIEDESAGSDDEDSDDSVEIIE
What are the official names of this protein?
Periodic tryptophan protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PWP2 family.
Protein: KLHL3_RAT
Sequence: MEGESVKPSPQPTEQAGDGEKNRRMITVNPAHMGKAFKVMNELRSKRLLCDVMIVAEDVEVEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLDHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEGRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGQWVSASGA
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron.  The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity).  The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity).
What are the official names of this protein?
Kelch-like protein 3.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
Protein: FZD2_HUMAN
Sequence: MRPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV
What is the function of this protein?
(Microbial infection) Acts as a receptor for C. difficile toxin TcdB in the colonic epithelium (PubMed:27680706, PubMed:29748286).  TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling (PubMed:29748286).
What are the official names of this protein?
Frizzled-2, Fz-2, hFz2, FzE2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: AROC_DECAR
Sequence: MSGNTFGTLFTVTSFGESHGPAIGCVVDGCPPGLALCEADIQAELDRRKPGTSRHVTQRREPDTVEILSGVFEGKTTGTPIGLLIRNQDQRSKDYGNIADTFRPGHADYAYTQKYGFRDYRGGGRSSARETAVRVAAGAIARKWLHERFGVAIRGWMSALGPIEIPFVSADAIDGNAFFAPNSAIVPELEAYMDKLRKSLDSVGAKITVTATGVPPGWGEPVYDRLDAEIAYAMMGINAVKGVEIGAGFDSVAQKGSEHGDEMTPQGFATNHAGGVLGGISTGQEIVVNMAIKPTSSIAQSRRSINRQGEAIEVATEGRHDPCVGIRATPIAEAMLALVLMDHALRHRAQCGDVLCATPRIPGKIA
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: BIOD_BRUA2
Sequence: MNSRLIVTGTDTGIGKTVFSAALCHALGAVYWKPVQSGLEEETDSEIVARLAQASPQRILPEAWRLNTPASPHLSARLDGVEIRPEEMHIPATSLPLVIEGAGGLLVPLNDKTLFADLFAIWRIPAILCARAALGTINHTLLSLEAMRSRDIPVLGVAFISEANEDTETTIAHLGRVKRLGRLPLLDDLSPEKLHHSFARNFHIDDFAGVAR
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_IBDVA
Sequence: MSDVFNSPQARTKISAAFGIKPTAGQDVEELLIPKVWVPPEDPLASPSRLAKFLRENGYKILQPRSLPENEEYETDQILPDLAWMRQIEGAVLKPTLSLHWGPRVLPKVLLNSPPEQGKAQCVPTRHCTTQADIYLFLQVPEATESLKDEVTLLTQNIRDKAYGSGTYMGQATRLVAMKEVATGRNPNKDPLKLGYTFESIAQLLDITLPVGPPGEDDKPWVPLTRVPSRMLVLTGDVDGDFEVEDYLPKINLKSSSGLPYVGRTKGETIGEMIAISNQFLRELSALLKQGAGTKGSNKKKLLSMLSDYWYLSCGLLFPKAERYDKSTWLTKTRNIWSAPSPTHLMISMITWPVMSNSPNNVLNIEGCPSLYKFNPFRGGLNRIVEWILAPEEPKALVYADNIYIVHSNTWYSIDLEKGEANCTRQHMQAAMYYILTRGWSDNGDPMFNQTWASFAMNIAPALVVDSSCLIMNLQIKSYGQGSGNAATFINNHLLSTLVLDQWNLMKQPNPDSEEFKSIEDKLGINFKIERSIDDIRGKLRQLVPLAQPGYLSGGVEPEQSSPTVELDLLGWSATYSKDLGIYVPVLDKERLFCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGGWNYPLLNKACKNNASAARRHLEAKGFPLDEFLAEWSELSEFGETFEGFNIKLTVTRENLAELNKPVPPKPPNVNRPVNTGGLKAVSNALKTGRYRNEAGLSGLVLLATARSRLQDAVKAKAEAEKLHKSKPDDPDADWFERSETLSDLLEKADVASKVAHSALVETSDALEAVQSSSVYTPKYPEVKNPQTASNPVVGLHLPAKRATGVQAALLGAGTSRPMGMEAPTRSKNAVKMAKRAQRQKESRQ
What is the function of this protein?
RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA.  May also contain guanylyl and methyl transferase activities (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, RDRP, Protein VP1.
What are the subcellular locations of this protein?
Virion. Note=Minor amounts are incorporated in the virion.
Protein: CYB_JACJA
Sequence: MTNIRKTHPLMKIVNESFIDLPTPSNISAWWNFGSLLGMCLIIQIATGLFLAMHYTSDTTTAFSSVAHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGLYYGSYTFIETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIVAALAVVHLLFLHETGSNNPIGLNSDADKNPLHPYYTIKTALGFLLMFLVLLSLVLFCPDMLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVVALVLSILILAIVPFLHNSKQRSMIFRPISQCMYWLLMADLLTLTWIGGQPVEHPFIIIGQIASILYFTIILILMPLSSMLENKILKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CABP2_MOUSE
Sequence: MGNCAKTPWHRGSKERWQWPGSPLGGSRPSPGPRTEEQEGTQGYSVLGSLVGPACIFLRPSIAATQLDRELRPEEIEELQIAFQEFDRDRDGYIGYRELGACMRTLGYMPTEMELIEISQQISGGKVDFEDFVELMGPKLLAETADMIGVRELRDAFREFDTNGDGCISVGELRAALKALLGERLSQREVDEILQDIDLNGDGLVDFEEFVRMMSR
What is the function of this protein?
Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1. 3 (Cav1. 3) in the IHCs (PubMed:28183797).  Required for the normal transfer of light signals through the retina (PubMed:27822497).
What are the official names of this protein?
Calcium-binding protein 2, CaBP2.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus.
Protein: Y3391_BURM1
Sequence: MNPITPSEFRQSVRRGAFRGPTAGHCGPFAQANLAILPDAYAHDFLRFCQANPKACPLLGVGEPGAFRLDVLGDDLDIRTDVPSYNVYRDGRLTERVDSLEALWRDDFVAFAIGCSFSFEDMLAREGIALRHVEEGRNVPMYRTSIPNRRAGVFGGQLVVSMRPMRGADAIRAVQITSRFPGVHGAPIHLGDPRELGIADLGAPDFGDAVTIREGELPVFWACGVTPQTALMEAKLPLAIAHTPGHMLMTDITNASLAVF
What are the official names of this protein?
Putative hydro-lyase Bmul_5125/BMULJ_03391.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: CH60_ECO57
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRVASKLADLRGQNEDQNVGIKVALRAMEAPLRQIVLNCGEEPSVVANTVKGGDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKNDAADLGAAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.