PharMolix/UniProtQA huggingface dataset:
Protein: EFTU_RHOPA
Sequence: MAKAKFERTKPHCNIGTIGHVDHGKTSLTAAITKVLAETGGATFTAYDQIDKAPEEKARGITISTAHVEYETQNRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPALVVFLNKCDMVDDPELLELVEMEVRELLSKYDFPGDDIPIVKGSALAALENSDAKLGHDAILELMRQVDAYIPQPERPIDQPFLMPVEDVFSISGRGTVVTGRVERGILKVGDEIEIVGIRDTQKTTCTGVEMFRKLLDQGQAGDNIGALLRGTKREDVERGQVLCKPGSVKPHTKFKAEAYILTKEEGGRHTPFFTNYRPQFYFRTTDVTGVVHLPEGTEMVMPGDNIAMEVHLIVPIAMEEKLRFAIREGGRTVGAGVVAAIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_STAAE
Sequence: MADLSSRVNELHDLLNQYSYEYYVEDNPSVPDSEYDKLLHELIKIEEEHPEYKTVDSPTVRVGGEAQASFNKVNHDTPMLSLGNAFNEDDLRKFDQRIREQIGNVEYMCELKIDGLAVSLKYVDGYFVQGLTRGDGTTGEDITENLKTIHAIPLKMKEPLNVEVRGEAYMPRRSFLRLNEEKEKNDEQLFANPRNAAAGSLRQLDSKLTAKRKLSVFIYSVNDFTDFNARSQSEALDELDKLGFTTNKNRARVNNIDGVLEYIEKWTSQRESLPYDIDGIVIKVNDLDQQDEMGFTQKSPRWAIAYKFPAEEVVTKLLDIELSIGRTGVVTPTAILEPVKVAGTTVSRASLHNEDLIHDRDIRIGDSVVVKKAGDIIPEVVRSIPERRPEDAVTYHMPTHCPSCGHELVRIEGEVALRCINPKCQAQLVEGLIHFVSRQAMNIDGLGTKIIQQLYQSELIKDVADIFYLTEEDLLPLDRMGQKKVDNLLAAIQQAKDNSLENLLFGLGIRHLGVKASQVLAEKYETIDRLLTVTEAELVEIHDIGDKVAQSVVTYLENEDIRALIQKLKDKHVNMIYKGIKTSDIEGHPEFSGKTIVLTGKLHQMTRNEASKWLASQGAKVTSSVTKNTDVVIAGEDAGSKLTKAQSLGIEIWTEQQFVDKQNELNS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: COAA_STRP3
Sequence: MSNKFINFEKISRESWKTLHQKAKALLTQEELKSITSLNDNISINDVIDIYLPLINLIQVYKIAQENLSFSKSLFLKKDIQLRPFIIGISGSVAVGKSTTSRLLQLLLSRTHPNSQVELVTTDGFLYPNQFLIEQGLLNRKGFPESYNMELLLDFLDSIKNGQTAFAPVYSHDIYDIIPNQKQSFNNPDFLIVEGINVFQNQQNNRLYMSDYFDFSIYIDADSSHIETWYIERFLSILKLAKRDPHNYYAQYAQLPRSEAIAFARNVWKTVNLENLEKFIEPTRNRAELILHKSADHKIDEIYLKK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_METM5
Sequence: MISDNVKKGVIRSPNRALLKACGYSDEDMEKPFIGVVNSFTEVVPGHIHLKTLSDAVKHGVYANGGTPFEFNTIGICDGIAMGHEGMKYSLPSREIIADAVESMARAHGFDGLVLIPTCDKIVPGMIMGALRLNIPFIVVTGGPMLPGEFQGKKCELISLFEGVGEYQVGKITEEELKSIEECACPGAGSCAGLYTANSMACLTEALGLSLPMCATIHAVDAQKVRIAKKTGSKIVDLVKEDVKPTDILTKEAFENAILVDLALGGSTNTTLHIPAIANEIENKFITLDDFDRLSDEVPHIASIKPGGEHYMIDLHNAGGIPAVLKVLKEKIRNTKTVDGRSTLEIAESVKYVNYDVIRKVEAPVHETAGLRVLKGNLAPNGCVVKIGAVDPKMHKHEGPAKVYNSEDEAIAAILGGKIVEGDVVVIRHEGPSGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHVSPEAAAGGLIAAIENGDIIKIDMIEKEINVDLDESVIKERLSKLEEFEPKIKKGYLSRYSRLVSSADEGAVLK
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: SIRT1_DROME
Sequence: MMENYEEIRLGHIRSKDLGNQVPDTTQFYPPTKFDFGAEILASTSTEAEAEAEATATTTEPATSELAGKANGEIKTKTLAAREEQEIGANLEHKTKNPTKSMGEDEDDEEEEEEDDEEEEEDDEEGITGTSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGDSDVIINQICHRLSDNDDCWRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIKSNSSADYILGSAGTCSDSGFESSTFSCGKRSTAAEAAAIERIKTDILVELNETTALSCDRLGLEGPQTTVESYRHLSIDSSKDSGIEQCDNEATPSYVRPSNLVQETKTVAPSLTPIPQQRGKRQTAAERLQPGTFYSHTNNYSYVFPGAQVFWDNDYSDDDDEEEERSHNRHSDLFGNVGHNYKDDDEDACDLNAVPLSPLLPPSLEAHIVTDIVNGSNEPLPNSSPGQKRTACIIEQQPTPAIETEIPPLKKRRPSEENKQQTQIERSEESPPPGQLAAV
What is the function of this protein?
NAD-dependent histone deacetylase involved in heterochromatic silencing.  Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV).  Required for epigenetic silencing of the polycomb group proteins.  Has histone H4 deacetylase activity in vitro.  Required maternally for establishing proper segmentation of the embryo.  Involved in sex determination.  May be involved in the regulation of life span.
What are the official names of this protein?
NAD-dependent histone deacetylase sirtuin-1, Silent information regulator 2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome.
Protein: E75BA_DROME
Sequence: MVCAMQEVAAVQHQQQQQQLQLPQQQQQQQQTTQQQHATTIVLLTGNGGGNLHIVATPQQHQPMHQLHHQHQHQHQHQQQAKSQQLKQQHSALVKLLESAPIKQQQQTPKQIVYLQQQQQQPQRKRLKNEAAIVQQQQQTPATLVKTTTTSNSNSNNTQTTNSISQQQQQHQIVLQHQQPAAAATPKPCADLSAKNDSESGIDEDSPNSDEDCPNANPAGTSLEDSSYEQYQCPWKKIRYARELKQRELEQQQTTGGSNAQQQVEAKPAAIPTSNIKQLHCDSPFSAQTHKEIANLLRQQSQQQQVVATQQQQQQQQQHQHQQQRRDSSDSNCSLMSNSSNSSAGNCCTCNAGDDQQLEEMDEAHDSGCDDELCEQHHQRLDSSQLNYLCQKFDEKLDTALSNSSANTGRNTPAVTANEDADGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTEHKELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALASSAPLLAATLSGGCPLRNRANSGSSGDSGAAEMDIVGSHAHLTQNGLTITPIVRHQQQQQQQQQIGILNNAHSRNLNGGHAMCQQQQQHPQLHHHLTAGAARYRKLDSPTDSGIESGNEKNECKAVSSGGSSSCSSPRSSVDDALDCSDAAANHNQVVQHPQLSVVSVSPVRSPQPSTSSHLKRQIVEDMPVLKRVLQAPPLYDTNSLMDEAYKPHKKFRALRHREFETAEADASSSTSGSNSLSAGSPRQSPVPNSVATPPPSAASAAAGNPAQSQLHMHLTRSSPKASMASSHSVLAKSLMAEPRMTPEQMKRSDIIQNYLKRENSTAASSTTNGVGNRSPSSSSTPPPSAVQNQQRWGSSSVITTTCQQRQQSVSPHSNGSSSSSSSSSSSSSSSSSTSSNCSSSSASSCQYFQSPHSTSNGTSAPASSSSGSNSATPLLELQVDIADSAQPLNLSKKSPTPPPSKLHALVAAANAVQRYPTLSADVTVTASNGGPPSAAASPAPSSSPPASVGSPNPGLSAAVHKVMLEA
What is the function of this protein?
Implicated in the regulation of ecdysone-triggered gene hierarchies.  Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone.
What are the official names of this protein?
Ecdysone-induced protein 75B, isoform A, E75-B, Nuclear receptor subfamily 1 group D member 3, isoform A.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: NAGZ_NEIM0
Sequence: MTVPCIPRGLVMADIAAFRLTEEEKQRLLDPAVGGVILFRRNFQNIAQLKELTAEIKALRTPELIIAVDHEGGRVQRFIEGFTRLPAMSTLGEIWDKDGASAAETAAGQVGRVLATELSACGIDLSFTPVLDLDWGNCPVIGNRSFHRNPEAVARLALALQKGLEKGGMKSCGKHFPGHGFVEGDSHLVLPEDGRSLSELEAADLAPFRIMSREGMAAVMPAHVVYPQVDTKPAGFSEIWLKQILRRDIGFKGVIFSDDLTMEGACGAGGIKERARISFEAGCDIVLVCNRPDLVDELREDFRIPDNPALAQRWQYMANTLGSAAAQAVMQTTDFQAAQAFVAGLASPQDTAGGVKVGEAF
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRD1_RAT
Sequence: MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
What is the function of this protein?
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
What are the official names of this protein?
D(1A) dopamine receptor, Dopamine D1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.
Protein: TRMB_MYCLE
Sequence: MARHLPATAFRKRRSALSHAQRQTWERLWPEIGISAVSQTRSAERLDTGAWFGRSTLVVLEVGCGSGTATLAMAQHEPDIDVIAVEVYRRGLAQLLCAIDRDQVHNIRMIHGNALYVLQYLIAPRSLTGVRVFFPDPWPKVRHHKRRFLQPATVELIADRLLPGGVLHTATDHPDYAKQIAKFGDGEPLLSRADGRTQLPISTVRPTTKYETKAQHAGNVVTELIWKKRS
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RSKA_MYCBO
Sequence: MTEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAFNDEVRAVRETMAVVSAATTAEPPAHLRTAILDATKPEVRRQSRWRTAAFASAAAIAVGLGAFDLGVLTRPSPPPTVAEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNVAPPSRGTVYQMWLLGGAKGPRSAETMGTAAVTPSTTATLTDLGASTALAFTVEPGTGSPQPTGTILAELPLG
What is the function of this protein?
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK.  ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP).  However, in M. bovis this protein is probably dysfunctional, due to at least 1 of the 2 naturally occurring polymorphisms in its gene, when compared to M. tuberculosis.  This leads to an increased expression of SigK-regulated genes, such as mpb70 and mpb83.  RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses.  The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor.
What are the official names of this protein?
Dysfunctional anti-sigma-K factor RskA, Regulator of SigK, Sigma-K anti-sigma factor RskA.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-K factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MTNW_MICAE
Sequence: MTIIVDYRFPPAINAEKQAKTIAIGQTAGTWSERHSHRQKQLQQHLAEVVGIREEADGYKVARVRFPQINVENDIASLLTMIFGKYSMAGAGKVVGVYLPESYGTKAKLGITGIRQRLGVYDRPLVMAIFKPALGLSAQDHADILREVAFAGLDVIKDDEIMADLPVAPTHERLDCCRRVLEEVRQQTGRNVLYAVNVTGKADELQRKARLLVKHGANALLLNVLTYGFSVLEALASDPAIDVPIFAHPAFAGAMCAGSDTGLAYSVVLGTMMAHAGADAVLYPAAYGSLPFDPQEEGKIRDILRDRNVFPVPSAGIRPGIVPQVLGDYGRNVILNAGTGIMDHPSGPASGVRAFFEALARIEAGESFDPANLPEGALKQAILEWG
What is the function of this protein?
Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P).
What are the official names of this protein?
2,3-diketo-5-methylthiopentyl-1-phosphate enolase, DK-MTP-1-P enolase, RuBisCO-like protein, RLP.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type IV subfamily.
Protein: Y2302_STREE
Sequence: MSISFRTNTSMMNIAYKNRDLSDEEFKEEAHQFRDKEIKILEEKLKELNISCKVVGINSIKDMNEYKEIMENVNQAKEELKRIDELIAVRSSRIDFLEDKTLRITGNQR
What are the official names of this protein?
Uncharacterized protein SPD_2302 homolog.
Protein: YKM6_SCHPO
Sequence: MSASHPGILHEYTERLVAFELVGKSNVTLTSNVTRSLLLFVGGLGDGLLTVPYVQELVNPLDEIGWSIVQVQTQSSYIGWGTGSLKRDDEDLHKAVDYFLHIGGADFSTRKIVLMGHSTGSQNVLYYLTQSILPNYLIAGIAQAPVSDREAAYQFNGKEKTKELVDWVKAEYLDKGLGNDVLPRSKVENFFGEVPTSANRCIDLTDVRGNDDFFSSDLSADDFAKTFGNLKEISGSTAHSQLILLMSERDEFVSPSTDKAQLLNRFRESIRPTTSNSSLSGIIPGATHNVGPKSSPEALKWLINQLITALRSFIDQ
What are the official names of this protein?
UPF0613 protein PB24D3.06c.
What is the protein family that this protein belongs to?
Belongs to the UPF0613 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PDXT_HYPBU
Sequence: MVVVGVLALQGDWIEHIELLREIEGVEAVPVKTEKQLESIDALIIPGGESTTIGRLIERRGLLEPLRDRIRAGLPVLGTCAGSILLAKKVRDRVVGPVEQPLLAVMDIAVLRNAFGRQMNSFEAEVHIEGVGTVHAAFIRAPIIEETWGEARPIAKLNHPLLGEVTVAARQKAIIATVFHPEITGDSKLHKLLVAAAKGRAF
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: HEM1_DESPS
Sequence: MFEKQVFLFGVNHKTTPVAVREKIAFTDGYETALTRLQEEVGCDESYLLSTCNRVEILVYADSTRDIEAEVSRFLFAGKVPEEDCRDYLYALKGLPAVQHLFTVAASLDSMVVGEAQILGQLKTAYRHASALGCTGPLLNRLLHKSFSVAKRVRTETAIGASAVSISYAAVQLARKIFGNLDTKKVMLVGAGEMAELAAEHLVGQGVSSVVVANRTLTRAVELADKFGGTAICMEELYAQLEDVDIIISSTGAQHIIIESAEVRPIMRVRRNRPLFFIDIAVPRDLDPELNELENVYLYDIDDLSNVVEVNKSGRDHEAIKAGCIVEEETRKFDEWYQGLAVKPTVLALREKMSGIIEQELRKTLPRLHDLGEHDQRSIEKMVASISSKFLHDPLHYLKSDSCHGRDKSQAKVDTLRSVFSLKGDI
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: QUEF_SYNY3
Sequence: MTETTITTSDNVEKYGEREIRDAQLITFPNPRPGRRYDVHITLPEFTCKCPFSGYPDFATLYLTYCPDQKVVELKSIKLYINSYRDRHIPHEEVTNQILDDFVAVANPLYARLKADFNPRGNVHTVIEVEYHQEKAS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_LARHH
Sequence: MSEQDITSQPAQDENQIMAERRQKLTEIRTSKGIAFPNDFRRQHLAAPLHAQYDATDKEALEAQPVEVVVAGRMMLKRVMGKASFATVQDSSGRIQFYISRDKVGEDVYADFKTWDMGDILGAKGTLMKTKTGELSVEVSELRLLSKSLRPLPDKFHGLADQEQKYRQRYVDLIINQDSRDTFIKRSKIVQTVREVMVGEDYLEVETPMMHPIPGGAAAKPFVTHHNALDMPLYLRIAPELYLKRLVVGGLERVFEINRNFRNEGMSTRHNPEFTMIEFYEAYCGYERMMEMTEKIIRRCAEAACGTTKVTYNGKEVDLGKPFDRFTIVGAIKHYNPQYTDEQLADEAWLKSEIKALGGKLPPAPGIGSLQLALFEECAEGKLWNPTFIIDYPVEVSPLARGSDADPSITERFELFIVGREHANGYSELNDPEDQAARFRSQVEQKDAGDDEAMHYDADYIRAMEYGLPPTGGCGIGIDRLVMLLTDAPSIRDVILFPHMRPE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFAB_PANTR
Sequence: MGSNLSPQLCLMPFILGLLSGGVTTTPWPLAQPQESCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQVQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATHPKIWVKVSDPDSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDIPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKAAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
What is the function of this protein?
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb.  Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase.  It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes.  Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).
What are the official names of this protein?
Complement factor B, C3/C5 convertase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RIMP_SHEAM
Sequence: MATLETRLAEMLTPAVEAAGYVVWGIEYVQAGKHSILRVYIDSEQGISVDDCADASRQISAILDVEDPISNEYTLEVSSPGLDRPLFNAAQYARYVGEDVKVQLTMPVEGSRNLKGVIDKVEGQMLTIKVDGKTLVVALDNIRKGNIIAKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFNG_PANTR
Sequence: QDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAVKTGKRKRSQMLFRGRRASQ
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma, Immune interferon.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: COAD_STACT
Sequence: MTESKAVIPGSFDPITYGHMDIIERVAQRFDEIHICVLKNSNKEGTFTVEERMALIEASVADIPNVEVHQFNGLLVDFCDEVGAKTIIRGLRAVSDFEYELRLTSMNKKLNSDVETLYMMTSTNYSFISSSVVKEVAQYKADISEFVPEPVEKALKEKFGK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COF_ECO55
Sequence: MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGRVTKICFCGGHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: EFG2_TREPA
Sequence: MRQQQMRNIGIMAHVDAGKTTTTERMLFYTGKIHRMGEIDDGATTMDWMVQEQERGITIQSAATTVRWREVDITIIDTPGHVDFTAEVERALRVLDGVVVVLCAVGRVQPQTETVWYQADRYDIPRVCFVNKMDRIGADFFSVLDQVHNKFGIDAVALQIPIGSGTSFEGVIDLITMKEIFWDAASSGEQMEYRPIQSARIAQAREAREKMLDVISIYSDEVTECVLAGEHVPVQLLHAEIRKAVRERRYVPFLCGSSRHNLGVQPLLDAVVEYLPAPQERKAVEGFHVQKKEPVFIAPTAEGPLLALVFKIQYEREAGLLCYVRMYSGKLRTGDSIVNIGKKKRERVYRILRMHSNKSETVECIQAGDIAVIVGLKSAQTGDSVGDGSCPVVLESMHFPEPVISVSLEPMDASSRDKLQETLGILSREDPTFSVREDAETGQLLISGMGELHLDVLTTRMREDFNVQVRVGKPHVTYRESIRKTVERTLRVQRVIGGKEYMAGLTLRVEARKRGAGNEFFCQVKELRGTVCTAHTAPAEIIGAVEHAIRGAWDGGIQSGYPCVDVGVHLLSVEYQELTSSPFIFEAAAVQAFGEACVAAEPYVLEPIMSVELSCAQENVGDVMNVIIQRGGIILGMDSKHGRELVHAQAPMKKMFGFSTDVRSASRGGASFTMRFSHFESCA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor G 2, EF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.