PharMolix/UniProtQA huggingface dataset:
Protein: CLPP2_SYNE7
Sequence: MFSSHASLPIHSRRLAAGLDSRWQQPQIQAIAGSQAIVPTVVEQSGRGERAFDIYSRLLRERIVFLGTGVDDAVADSIVAQLLFLEAEDPEKDIQLYINSPGGSVTAGMAIYDTMQQVAPDVATICFGLAASMGAFLLSGGAQGKRMALPSARIMIHQPLGGAQGQAVDIEIQAREILYHKSTLNDLLAQHTGQPLEKIEVDTDRDFFMSPEEAKAYGLIDQVLTRPTMAITDHNDAVLQ
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_CLOB8
Sequence: MEICKRVEQVDFEKMNGLIPTIVQDYKTKEVLMLAYMSKESLNKTLEDNTTWFYSRSRDELWNKGATSGHFQYVKEIKIDCDNDTILILAEQVGAACHTGNRTCFYRDL
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GVPH_HALMT
Sequence: MSPNLNGPGGSDDSDRPDEPDDSDRPDESNSTGNPDTPDDRPNKTPDRPSDHPSSLLDQLRAILETLAEIEEDGHRQGHGRIDRGNAQIDYDYEVSFGLGPRSRRGKPSDEPRVEAPRTEGTDSQPEGEKSIHIETRETDDGERVVIADLPGVADDELDVTLDADESALELRTDEGIVGRVPLDQPDVEITDVRLRNQVLEIRLTRTNESNGSESK
What is the function of this protein?
May play a structural or regulatory role in gas vesicle synthesis.
What are the official names of this protein?
Protein GvpH.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: PCDG8_HUMAN
Sequence: MAAPQSRPRRGELILLCALLGTLWEIGRGQIRYSVPEETDKGSFVGNISKDLGLDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDREELCAQSPRCLININTLVEDKGKLFGVEIEIIDINDNNPKFQVEDLEVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLSPNHHFSLDVQTGDNGAINPELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLLISVEDVNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTRDNLPFKLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGAPLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLTELGSLKPSVDPNDSSLTLYLVVAVAAISCVFLAFVAVLLGLRLRRWHKSRLLQDSGGRLVGVPASHFVGVEEVQAFLQTYSQEVSLTADSRKSHLIFPQPNYADMLISQEGCEKNDSLLTSVDFHEYKNEADHGQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin gamma-A8, PCDH-gamma-A8.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RS13_GLOC7
Sequence: MARIAGVDLPRDKRVEIALTYLYGIGLSRSKEILANTGVNPDTRVKDLSDEDALALRSYIEANYQIEGDLRRWETMNIKRLVDIGTYRGRRHRQGLPVRGQRTRTNARTRRGRRLTVAGKKKAPSKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: PFER_PSEAE
Sequence: MIVQPSAVAKGWPIATTLLPASCGPADPKPEPKPKQRRLCRKVFPLRARCGALAHCPIPGKNEIFTNVNHSHISIPSPRLLLVEDDPRLREDLDAHFRRRGFRVTVCGDGSHGLEAAGREAFDLVLLDIMLPGLDGLALLESLRREQATPVMLMSALGAEQDRISGFTRGADDYLPKPFSLAELDARTDALLRRVRLDRLPLAQRRDTRLVFDDQAQDVLHQGLPAGLTPSEYRLLATLREHAGEALSKPFLYRSVLHRSYTRLDRGLDVHVCNLRRKLAVVAVRHLQIQAVRGQGYLLVETEHP
What is the function of this protein?
Member of the two-component regulatory system PfeR/PfeS.  Activates expression of the ferric enterobactin receptor.
What are the official names of this protein?
Transcriptional activator protein PfeR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XYLT1_HUMAN
Sequence: MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGGRGPQARARGGGPGEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR
What is the function of this protein?
Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN.  Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:15461586, PubMed:17189265, PubMed:24581741, PubMed:23982343).  Required for normal embryonic and postnatal skeleton development, especially of the long bones (PubMed:24581741, PubMed:23982343).  Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity).
What are the official names of this protein?
Xylosyltransferase 1, Peptide O-xylosyltransferase 1, Xylosyltransferase I, XT-I, XylT-I.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 14 family. XylT subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Note=Detected predominantly in the Golgi apparatus.
Protein: CDO1_MOUSE
Sequence: MERTELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNPAEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTPFTTSGSLENN
What is the function of this protein?
Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
What are the official names of this protein?
Cysteine dioxygenase type 1, Cysteine dioxygenase type I, CDO, CDO-I.
What is the protein family that this protein belongs to?
Belongs to the cysteine dioxygenase family.
Protein: KEX1_LACTC
Sequence: MSHFKYRNQTTDICNAAALDAFAMYSNYSVPLALLFALLLSFQTARALKAADEYAVSPDLIPGLSQAEDRALVPTMHAGHIPLDENNDEHTKNYFFWKFHDESGSASGPARDTLIFWLNGGPGCSSMDGALMESGALRIDSDGKAYLNRGGWHTRGDIVFVDQPAGTGFSTVASDNDYDNDLKVVSEHFVAFLRNYFQVFPDDAGKQVVFAGESYAGQFIPYFARAVLDQDEVQVNLQALLIGNGWIDPNQQSLYYIPFAVEKGLITQDDPSFSYLLKQQENCQNKINSKENDRFSFKECENILNNLLEVTRKIKDSEGKKVPSDQQCINMYDLRLKDSYPSCGMNWPQDLPNLGKFFGTEGVLEALHLDPEHVSQWHECDDKVSNYLKNPDSRASAAILPGLLEAGLEVMLFNGDQDIICNNMGVEAVISQMSWGGETGFSENVQLYDWVYRSPENSEITPAGFVKYDRNLTFMSVYNASHMVPFDNALVSRGVVDLFLNDVDLVQIDGRDTLITDDVNKGKDGDASETDDTTELDCEGKDKLSEECKQLNASKGQNGESDKDEGEKGNEEDDNDDTEDGKKDAGDEKDDGEKDDDEKDGDEKDGDEKDEEDDDDKDENEKDEEDDDKDGDKPEGKNNDGAEDEDDDHNSGSHLAVTMICLLVSGTIIGGLYFTFRDRFRPRLRAILVDPTNRSEASKKTVSWAADLEQDAADLSNPENGAKKKGPYTSVPTQESRDSFELDNL
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase KEX1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: CRCB_ACIBT
Sequence: MYYPLLSIALGSVLGAWLRWFLGLKLNPIYPQIPLGTVTVNLVGGFIIGFAMAYFAHSDLSPNYKLFVITGFCGALTTFSTFSIEIVTLLQSGKWGMAMLAISIHLIGSLIFTCLGLAAYYWVAGH
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PHAG_PSEAE
Sequence: MRPETAIIEIHGQYRIHTEFYGNPAAQQTIILVNGSLSTTASFAQTVKYLQPHYNVVLYDQPYAGQSKPHNENHTPISKECEARILLELIERFRAEVVMSFSWGGVATLLALAQRPGRIRRAVVNSFSPQLNPAMLDYLHRGLDYLAACDRTQIGNLVNETIGRYLPQLFKRYNFRHVSSLDEHEYHQMHFHIREVLRLNADSYTESFAGIEIPMLFMNGELDIYTTPHEARQFGQLIRGAEFHTIRNAGHFIDVEHKAAWQQTQDALLAFLRPQRTQPLNPIYRPQPNGASVPLAALAS
What is the function of this protein?
Catalyzes the transfer of the acyl moiety from in vitro synthesized 3-hydroxydecanoyl-CoA to acyl carrier protein.
What are the official names of this protein?
(R)-3-hydroxydecanoyl-ACP:CoA transacylase, 3-hydroxyacyl-CoA-acyl carrier protein transferase, Quinolone sensitivity protein.
Protein: HIS4_METTH
Sequence: MLIIPAVDIKDGKCVQLVQGKPGTEQVVLDDPAGVAGRWESLGAETIHVVDLDGALGLEKNTGILKEITERVSVPLQIGGGIRSREYAGKLLDMGFERVILGTMAIENPAIVEELAGEYGSERIMVSLDSRDSRVVIRGWTEKVPFTAEEMARKFQERGAGSILFTNVDFEGLLSGFDLKPVSELVEAVEIPVIYSGGVSSLNDLRMLQGTGVMGVVIGSAIYRGLIDLTEALKYQDLK
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_MYCUA
Sequence: MSTRRDLPQSPYLAAVAGRKPSRVPVWFMRQAGRSLPEYRALRRQHSMLAACFEPEVACEVTMQPIRRYHVDAAILFSDIVVPLRAAGVDLDIVADVGPVIAAPVRTVADVDAIKPIDSQSIAPVLDAVELLVAELGDTPLIGFAGAPFTLASYLVEGGPSRHHARTKAMMLAEPATWHALMTKLTDLTIEFLLGQIRAGVDAIQVFDSWAGMLSLADYRQYALPHSARVFATLAEHGVPMTHFGVGTAELLGAMSEAVKPGTAKVVGVDWRTALADAAARVQPGTALQGNLDPVVLLAGWPAVERAARAVVDDGRRAVDAGAAGYVFNLGHGVLPQTDPGVLTDLVSLVHSL
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_BLOPB
Sequence: MSGIKGTSQEYIGHHLYHLQFDLSTFSLVSSENTSSFWVLNVDSMFFSILLATLFLLIFGRLATVATYAVPTKLQVFIELVILFIDSNVKDMFHGKNKLIAPLSMTVFVWIFLMNTMDLFPIDLFPAIAKLLGLPALRVVPSADVNITSSLALNVFVLVMYYNIYVNGVHGFIKGLMYHPFNHPTCIPINFIIEVVSLLSKPVSLSLRLFGNMYSGELIFILISGLLPWWGQWVLNLPWAIFHILVVTLQAFIFMVLTVIYLSTAHDSC
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUOK_SULNB
Sequence: MIGLSHYLIVSALIFSIGLMGVLRRRNLLMLFFATEVMLNAVNIAFAAISHYYNDLTGQMFAFFIIAIAASEVAVGLGILIVLYKRYGSLDLDDLASMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTB_DICLA
Sequence: MDPCDCSKSGTCNCGGSCTCTNCSCTTCKKSCCPCCPSGCTKCASGCVCKGKTCDTSCCQ
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein B, MT-B.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: ACB1_BPS16
Sequence: MMKFQDFSSGLYVAAKFSDSTLDEIENLQRELKVPNPVPRHKIHSTICYSRVNVPYVVSTGSFEVANSGELQVWDTQDGRTLVLVLDSDYLKFRHNYARALGATHDFDDYSPHITLSYNVGPAQFSGIVQVPVILDREYKEPLKINWTEDLK
What is the function of this protein?
Counteracts the host CBASS antiviral defense system.  Phosphodiesterase that enables metal-independent hydrolysis of the host cyclic di- and trinucleotide CBASS signals such as 3'3'-cGAMP, 3'3'cUA, and 3'3'3'-cAAA (PubMed:35395152).  Does not cleave cGG or cA4 (By similarity).  Besides evasion of the CBASS system, might also enable evasion of the type III CRISPR systems that use cA3 signals (By similarity).
What are the official names of this protein?
Anti-CBASS protein Acb1, Acb1.
What is the protein family that this protein belongs to?
Belongs to the anti-CBASS protein Acb1 family.
Protein: DAPD_BURPS
Sequence: MSQQLQQIIDNAWENRAELSPKAASAEIREAVAHAIEQLDRGALRVAEKIDGAWTVHQWLKKAVLLSFRLEDNAPMPAGGYSQFYDKVPSKFANYTAEDFAAGGFRVVPPAIARRGSFIAKNVVLMPSYTNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPVIIEDNCFIGARSEVVEGVIVEENSVISMGVYLGQSTKIYDRETGEVTYGRIPAGSVVVAGNLPAKDGTHSLYCAVIVKKVDAKTRAKVGLNELLRGD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHS2_DAUCA
Sequence: MANHNAEIEEIRKRQRAQGPANILAIGTATPSNCVYQADYPDYYFRITNSEHMSDLKLKFKRMCEKSMIRKRYMHITEEYLKENPNVCAYEAPSLDARQDLVVVEVPRLGKEAAAKAIKEWGHPKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNTGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAVIVGSDPDLSVERPLFQLISAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFGPIGISDWNSLFWIAHPGGPAILDQVELKLGLKEEKMRATRQVLSDYGNMSSACVLFILDEMRKKSIEEGKATTGDGLDWGVLFGFGPGLTVETVVLHSVPATITH
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 2, DcCHS2, Naringenin-chalcone synthase 2.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: RPF2_HUMAN
Sequence: MDTLDRVVKPKTKRAKRFLEKREPKLNENIKNAMLIKGGNANATVTKVLKDVYALKKPYGVLYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLVIGRMYDYHVLDMIELGIENFVSLKDIKNSKCPEGTKPMLIFAGDDFDVTEDYRRLKSLLIDFFRGPTVSNIRLAGLEYVLHFTALNGKIYFRSYKLLLKKSGCRTPRIELEEMGPSLDLVLRRTHLASDDLYKLSMKMPKALKPKKKKNISHDTFGTTYGRIHMQKQDLSKLQTRKMKGLKKRPAERITEDHEKKSKRIKKN
What is the function of this protein?
Involved in ribosomal large subunit assembly.  May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.
What are the official names of this protein?
Ribosome production factor 2 homolog, Brix domain-containing protein 1, Ribosome biogenesis protein RPF2 homolog.
What is the protein family that this protein belongs to?
Belongs to the RPF2 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner.
Protein: MURC_PELPD
Sequence: MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSDITERLARLGAEIGIGHKADNLKDVDVVVISSAVHDDNPEVVEAKRLHVPVIPRAEMLAELMRMKFGIAIAGTHGKTTTTSMAASILGHAGIDPTIVIGGKLNAIGTNAQLGQGKFLLAEADESDGSFLVLSPTIAVVTNIDADHLDHYSGGIEEIKDTFVKFINKVPFYGMAVLCLDDPNIRAILPRVKKRYMTYGLSSQADIRATHVRHDGFTTSFTAHFKGYRLGEISFTMPGAHNVLNAMACIAVALELDVPFSAIQEGFSRFGGVGRRFTIKGEPRGITVVDDYGHHPAEIKATLAAARLGWPERRIVAVFQPHRYTRTHELFGEFVTAFYDADVLILTDVYAAGEQPVEGATAERLSQEILRHGQKDVTWIPNRELIPQHLLGIVKEGDMVITLGAGSIWQQGEALVTLLEKTS
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL1_HPV39
Sequence: MAMWRSSDSMVYLPPPSVAKVVNTDDYVTRTGIYYYAGSSRLLTVGHPYFKVGMNGGRKQDIPKVSAYQYRVFRVTLPDPNKFSIPDASLYNPETQRLVWACVGVEVGRGQPLGVGISGHPLYNRQDDTENSPFSSTTNKDSRDNVSVDYKQTQLCIIGCVPAIGEHWGKGKACKPNNVSTGDCPPLELVNTPIEDGDMIDTGYGAMDFGALQETKSEVPLDICQSICKYPDYLQMSADVYGDSMFFCLRREQLFARHFWNRGGMVGDAIPAQLYIKGTDIRANPGSSVYCPSPSGSMVTSDSQLFNKPYWLHKAQGHNNGICWHNQLFLTVVDTTRSTNFTLSTSIESSIPSTYDPSKFKEYTRHVEEYDLQFIFQLCTVTLTTDVMSYIHTMNSSILDNWNFAVAPPPSASLVDTYRYLQSAAITCQKDAPAPEKKDPYDGLKFWNVDLREKFSLELDQFPLGRKFLLQARVRRRPTIGPRKRPAASTSSSSATKHKRKRVSK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: SYA_HELPH
Sequence: MDIRNEFLQFFQNKGHAVYPSMPLVPNDATLLFTNAGMVQFKDIFTGIVPHPSIPRATSSQLCMRAGGKHNDLENVGYTARHHTLFEMLGNFSFGDYFKEEAILFAWEFVTKNLGFKPKDLYISVHEKDDEAVKLWEKFVPVDRIKKMGDKDNFWQMGDSGPCGPCSEIYIDQGEKHFKGSEDYFGGEGDRFLEIWNLVFMQYERSNDGVLSPLPKPSIDTGMGLERVQALLEHKLNNFDSSLFAPLMEEISELTSLDYTSEFQPSFRVVADHARAVAFLLAQGVHFNKEGRGYVLRRILRRALRHGYLMGLKEAFLYKVVGVVCEQFSNTHAYLKESKEMVMKECFEEEERFLETLESGMELFNLSLKHLNENKIFDGKIAFKLYDTFGFPLDLTNDMLRSHGACVDMQGFELCMQEQVKRSKASWKGKQDNADFSAILNAYAPNEFVGYETTECPAKALGFFDSDFKEIIEANPNQEVWVLLEKTPFYAEGGGAIGDRGALFKDNEEAAIVLDTKNFFGLNFSLLEIKKALKKGDQVIAQVSDERLEIAKHHSATHLLQSALREVLGSHVSQAGSLVESKRLRFDFSHPKVLNDEELEKVEDLVNAQIFKHLNSHVEHMPLNQAKDKGALALFGEKYAENVRVVSFKEASIELCGGIHVENTGLIGGFRIVKESGVSSGVRRIEAVCGKAFYQLAKEESKELKNAKTLLKNNDVIAGINKLKESVKNSQKAPVSVDLPVEKIHGVNLVVGVVEQGDIKEMIDRLKSKHERLLAMVFKKENERITLACGVKNAPIKANVWANEVAQILGGKGGGRDDFASAGGKDIENLQAALNLAKNTALKALEG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_METJA
Sequence: MKKVVLLTCTIIVGGQWGDEGKGKIISYICDKDKPSIIARGGVGPNAGHTVNIGGKSYGIRMIPTGFPYKEAKLAIGAGVLVDPEVLLKEVEMLKDFNVKERLIVDYRCGIIEEKHKIMDRKDEHLAKEIGTTGSGCGPANVDRVLRILKQAKDIEELKEFLGDVSEEVNNALDRGENVLIEGTQGTLLSLYYGTYPYVTSKDTTASSFAADVGIGPTKVDEVIVVFKTFPTRVGAGPFPTEMSLEEAESLGIVEYGTVTGRRRRVGYFDFELARKACRLNGATQIALTGLDKYDKECYGVTEYNKLSEKAKEFINKIEEVTGVPVTIISTGPEMHQTIDLRNEL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VAPC2_HAEI8
Sequence: MLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHFGNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system (PubMed:27672196).  Acts as an RNase (Probable).  Its toxic effect is neutralized by cognate antitoxin VapB2 but not by non-cognate antitoxin VapB1 (PubMed:27672196).
What are the official names of this protein?
Ribonuclease VapC, RNase VapC, Toxin VapC.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: LKTA_MANGL
Sequence: MGNKLTNISTNLKSSWLTAKSGLNRTGQSLAKAGQSLKTGAKKIILYIPKDYQYDTEKGNGLQDLVKAAEELGIEVQKEEGNDIAKAQTSLGTIQNVLGLTERGIVLSAPQLDKLLQKTKVGQAIGSAENLTKGFSNAKTVLSGIQSILGSVLAGMDLDEALQKNSNELTLAKAGLELTNSLIENIANSVKTLDAFGDQINQLGSKLQNVKGLSSLGDKLKGLSGFDKTSLGLDVVSGLLSGATAALVLADKNASTSRKVGAGFELANQVVGNITKAVSSYILAQRVAAGLSSTGPVAALIASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASVTAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEKNNHGKNYFENGYDARYLANLQDNMKFLLNLNKELQAERVIAITQQQWDNNIGDLAGISRLGEKVLSGKAYVDAFEEGKHLKADKLVQLDSANGIIDVSNSGKAKTQHILFRTPLLTPGTEHRERVQTGKYEYITKLNINRVDSWKITDGAASSTFDLTNVVQRIGIELDNAGNVTKTKETKIVAKLGAGDDNVFVGSGTTEIDGGEGYDRVHYSRGNYGALTIDATKETEQGSYTVNRFVETGKALHEVTSTHTALVGNREEKIEYRHSNNQHHAGYYTKDTLKAVEEIIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDIIDGGNGDDFIDGGKGNDLLHGGKGDDIFVHRQGDGNDIITDSDGNDKLSFSDSNLKDLTFEKVKHNLVITNSRKEKVTIQDWFREADFAKEVRNYKATKDEKIEEIIGQNGERITSKQVDDLIAKGNGKITQDELSKVVDNYELLKHSKNVTNSLDKLISSASAFTSSNDSRNVLVAPTSMLDQSLSSLQFARAA
What is the function of this protein?
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture.  The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell (By similarity).  This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis.  It has also week hemolytic activity.
What are the official names of this protein?
Leukotoxin, Lkt.
What is the protein family that this protein belongs to?
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein.
Protein: NAP1D_ARATH
Sequence: MSNEENIKSDNKSGDSSDLPTIPALDIGAEECDLLAELKNLTLKRPFDVKKLSPKVTKRVLFLKDIQVTHDELEEKFLAEKSALEATYDNLYKPLFAKRYEIVNGVVEAEAEKEGVPNFWLIAMKTNEMLANEITERDEAALKYLKDIRSCRVEDTSRNFKLEFLFDSNLYFKNSVLSKTYHVNDEDGPVLEKVIGTDIEWFPGKCLTHKVVVKKKTKKGPKKVNNIPMTKTENCESFFNFFKPPEIPEIDEVDDYDDFDTIMTEELQNLMDQDYDIAVTIRDKLIPHAVSWFTGEALVDEDDSDDNDDDDNDEKSD
What is the function of this protein?
May modulate chromatin structure by regulation of nucleosome assembly/disassembly.
What are the official names of this protein?
Nucleosome assembly protein 1;4, AtNAP1;4, Nucleosome/chromatin assembly factor group A4.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.