PharMolix/UniProtQA huggingface dataset:
Protein: TRPA_BURPS
Sequence: MSRIQNTFAALAAQGRKGLIPFITAGDPDPAKTVELMHALAEGGADVIELGVPFSDPMADGPVIQRSSERALAKGVTLHSVLDDVKRFRARDQKTPVVLMGYANPIERMGADAFAAAARDAGVDGVLVVDYPPEESHDFAAKMRAAGIDPIFLLAPTSTDDRIAAVGQVASGYVYYVSLKGVTGAANLDVSSIAGKIPAIKSRVPLPVGVGFGIRDAATARAVAEVADAVVIGSRLVQLLEQAAPERAAAELAGFVAELRVAIDGAAKPAA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RRP3_ENCCU
Sequence: MEFGDLRIDESLIKTCQEKGITRPTEVQRQVIPAVLGGGDVIAVSQTGSGKTLAFVLPIVSHLLQKNRSFYCLVVAPTRELSSQIAECFNMFQATGLRVCLLVGGANFNVQANQLSKRPHVVVGTPGRIAEHVLKTKSFRTERVRKFVLDEADRFFEQDFVEDLETIIPSLREKRQTLLFTATMSDEISKLSSSILKRPKTIRTAEKYETVPALKEYYLFVAMKWKNSALVELLEMSQGMSVIVFVSMCVTARVMSLALARLGFCSEALHGELSQEKREEAMRSFKESRFNVLVCTDLGSRGLDISHVDLVINFDVPKSGKDYIHRVGRTARAGRSGTAITLVTQYDVEQIQKIEFTLEKKLEEFKMMKKNFGTICARIEEAIQEAQETLKEERKRNRRP
What is the function of this protein?
ATP-dependent rRNA helicase required for pre-ribosomal RNA processing.  Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent rRNA helicase RRP3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RF2_BORPA
Sequence: MEAERQNQLVARLEDYAEREQALRRYLDYDAKSERLQVVNAELEDPAIWNDPKHAQDLGREKKSLEDVVETLTELGSGLADSCELVELALADSDDATLEAIEHDVDRFQEKLETLEFRRMFANPADPLNCFVDIQAGAGGTEAQDWASMLLRQYLKYAERKGFKAEILEESEGDVAGLKSATIKIEGEYAFGYLRTETGVHRLVRKSPFDSSGGRHTSFASVFVYPEVDESFEVEVNPADLRIDTYRASGAGGQHINKTDSAVRITHAPSGIVVQCQNDRSQHRNRAEAMQMLKSKLYELEMRNRMTEQQKLEDSKTDVGWGHQIRSYVLDQSRIKDLRTNVEISNTQKVLDGDLDPFIQASLKQGV
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_SHISS
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: CXCR4_CALJA
Sequence: MEGISIYTSDNYTEEIGSGDYDSIKEPCFREENAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGKFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIRQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
What is the function of this protein?
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation.  Involved in the AKT signaling cascade (By similarity).  Plays a role in regulation of cell migration, e. g.  during wound healing.  Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels.  Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity).  Involved in hematopoiesis and in cardiac ventricular septum formation.  Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells.  Involved in cerebellar development.  In the CNS, could mediate hippocampal-neuron survival (By similarity).
What are the official names of this protein?
C-X-C chemokine receptor type 4, CXC-R4, CXCR-4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) (By similarity).
Protein: FMT_LEIXX
Sequence: MRLVFAGTPAVAVPSLTALAARFEVAAVITREDAPLGRKRILTPSPVAIAAEELGLSVIRANRLREEAIERVRVLRPDVGVVVAYGGLVHEPLLSLPRRGWVNLHFSLLPRWRGAAPVQHALIAGDRETGAAVFQLVPELDAGDVFGELRRLIRPDETAGELLDDLARSGARLLADTVAALADGTAVATPQSGEPVAAPKLGIADAKLDLTRPADEVYARFRGVTPEPGAWALLDGERFKIHAVRPTAAGVLPPGAVVADGKRILAGTGSRPLELVTVQPAGKRVMAAADWWRGAGGEAVLS
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: TBP_METTP
Sequence: MESTINIENVVASTKLADEFDLVKIESELEGAEYNKEKFPGLVYRVKSPKAAFLIFTSGKVVCTGAKNVEDVRTVITNMARTLKSIGFDNINLEPEIHVQNIVASADLKTDLNLNAIALGLGLENIEYEPEQFPGLVYRIKQPKVVVLIFSSGKLVVTGGKSPEECEEGVRIVRQQLENLGLL
What is the function of this protein?
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
What are the official names of this protein?
TATA-box-binding protein, Box A-binding protein, BAP, TATA sequence-binding protein, TBP, TATA-box factor.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
Protein: KAD_STRCO
Sequence: MRIVLVGPPGAGKGTQATRLAETLHIPHISTGDLFRANISQQTELGKLAKSYMNAGNLVPDEVTIAMAKDRMEQPDAEGGFLLDGFPRNVSQAEALDELLETEGMKLDAVLDLEAPEDEVVKRIAGRRVCRNEPKHVFHVTYTPPKKEGVCDVCGGELYQRDDDSEETVRKRLEVYHTQTEPIIDYYKSQGLVATIAATGPVDEVTRRALEALKRDQ
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_ORITI
Sequence: MDPISFKYIAIAFMAFGMAGAALGVASIFNALMNSIARNPSAIEDLQKAALIGAGLAEAMGLFSFILAILLMFT
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTH_BARBK
Sequence: MLLIAGLGNPGSHYQNNRHNIGFMAVDAIHEAFSFSPWSKKFQAEVSNGLINGEKILLIKPQTFMNLSGQAIGEALRFYKLDLDHLIVFYDELDLPPGTVRVKIGGRSNGHNGIKSIDSHCGNNYHHVRLGIGRPISKELVDQYVLGNFTQSDQKWLSTLLGVIANNVAMLIKGDSNCFMNKISLTMKSQGLQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSAZ_BURM9
Sequence: MAEKTEKPTAKKLRDAAKKGQTFKARDIVALIVIATGALAAPALVDLTRIAAEFVRIASTGAQSNPGAYAFAWAKLFLRIAAPFVLLCAAAGALPSLVQSRFTLAVESIRFDLTALDPVKGMKRLFSWRSAKDAVKALLYVGVFALTVRVFADLYHADVFGLFRARPALLGHMWIVLTVRLVLLFLLCALPVLILDAAVEYFLYHRELKMDKHEVKQEYKESEGNHEIKSKRREIHQELLSEEIKANVEQSDFIVANPTHIAIGVYVNPDIVPIPFVSVRETNARALAVIRHAEACGVPVVRNVALARSIYRNSPRRYSFVSHDDIDGVMRVLIWLGEVEAANRGGPPPETRAPTSAEPQARDGVAPLGDACADNAFPDDAPPGAAAPNAGSPDSPAPDGGAPARTGDQNA
What is the function of this protein?
Part of the bsa type III secretion system, is involved in the intracellular replication of invading bacteria inside the host cell.  Probably necessary for the lysis of the vacuole membrane and escape into the host cell cytoplasm (By similarity).
What are the official names of this protein?
Secretion apparatus protein BsaZ.
What is the protein family that this protein belongs to?
Belongs to the type III secretion exporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FAR9_STRNA
Sequence: GRGGASNYVRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-9, FMRFa-9.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: HBEAG_HBVF1
Sequence: MQLFHLCLIIFCSCPTVQASKLCLGWLWGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYRDALESPEHCTPNHTALRQAILCWGELMTLASWVGNNLEDPAARDLVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.  This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein, p25.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: RL7_COPPD
Sequence: MTIEEIISEIENMSVSQLAELVKALEEKFGVSASMPVAVAAPVAGPAAAAPAEEEKTSFDVILKEAGAKKLEVIKVVREITGLGLKEAKDLVESAPKPIKEGVTKEEAEELKKKLEEAGAVIELQ
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: ACDH_BACPJ
Sequence: MNRTVKVAILGSGNIGTDLMYKILKKRWVLELSMIAGIDPQSEGLARARAEGVYATAGGIDAILEDPEIKIVFDATSAKAHLKHAKRLKEAGKVAIDLTPAAVGPYVVPPVNLMEHVDKDNVNLITCGGQATIPLVYAVSRVANVKYAEMVSTVSSSSAGPGTRQNIDEFTFTTSRGLEVIGGAEKGKAIIILNPAKPPILMRNTVYIAYEDGDDHQIRHSIGQMIHDVQQYVPGYRLKGEPIFDRRETPKGRLDVVILLLEVEGAGDFLPVSAGNLDIMTASAKQVGEVIAKRLIEMTSTA
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: NCBP2_SALSA
Sequence: MSSKLNALFSDSYVDVSQYRDQHFKGNRYEQEKLLKQANTLYVGNLSFYTTEEQVYELFSKSGDVKRIIIGLDKVKKTACGFCFVEYYTRTDAENAMRFVNGTRLDDRIIRTDWDAGFKEGRQYGRGKSGGQVRDEYRQDYDPARGGYGKVVSRP
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export.  The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore.  The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus.  The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E.  The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs.  The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2.  The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD).  During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference.  The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation.  In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure.  The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 2, 20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, CBP20.
What is the protein family that this protein belongs to?
Belongs to the RRM NCBP2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MLTC_HAEI8
Sequence: MKKYLLLALLPFLYACSNSSNQGINYDEAFAKDTQGLDILTGQFSHNIDRIWGVNELLVASRKDYVKYTDSFYTRSHVSFDEGNIVIETQQDLNRLHNAIVHTLLMGADAKGIDLFTSGDVPISSRPFLLGQVVDHQGQQIANQVIASNFATYLIQNKLQTRRLQNGHTVQFVSVPMIANHVEVRARKYLPLIRKAAQRYGIDESLILGIMQTESSFNPYAISYANAIGLMQVVPHTAGRDVFAMKGKGGQPSTRYLYDPANNIDAGVSYLWILQNQYLDGITNPTSKRFAMISAYNSGAGAVLRVFDNDKDTAIYKINQMYPEQVYRILTTVHPSSQARNYLLKVDKAQKKFRVRR
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: Y110_OSHVF
Sequence: MASKVYIDAFEDEWVLESDIQSTTTVTSDDKDEEMYYIIDRDTRKPVGFKIPKDDEKKLFLFDDKFRYIFGAASIDYAYYSPLCKYKVITSRTSPYLSHSVQYSRKTGRPGGREVCSKEEIERIDSLFTVIDVNAMESKLDKVKDIRESTIAEEYQIVLGKLKKDYIDFIMTGSELENRFETCVKVKFLLEKSQKISRHEPRSFYSMVDRIAPHTGLIMQNCNEDFSFKKAVDIAFFVSKQGSVLLNSHTKIATALKMITN
What are the official names of this protein?
Uncharacterized protein ORF110.
Protein: YL759_MIMIV
Sequence: MVLLTEEDYSDLNEDYFNDLADTLFNKCYLVANGSKWRLVEIEFYLNNENHADPYVHCDPDQLLSHTFYFHRFKNRTYKSGTFKGMDITLGTYPNDPKFKPKKTDTKTYFGILIRSVQRIKTGEIIEGPCNTVNKLLEQYEFTKIDELTGGESLDLFENDQNFYLKFTKSLKSEKIYSGPRIGLSDKFMEWRDLPYRYVIFKSSIKKRKTTLKELN
What are the official names of this protein?
Uncharacterized protein L759.
Protein: PLSX_ANASK
Sequence: MVGKIAPIAVDAMGGDHAPGAIVQGAVNAARKGLPVVLVGPEARVREELARHRAASSLPLEVHPATEVVEMHDHPGQAMRRKKDNSIRVCFELVASGRAAGMVSAGNSGAVMAGAILVLGRPEGVERPAIVSVLPALKGAPLMLDMGAVVDCRPIHLVQFALMGEVYSRRVHGVARPRVAILSNGEEDTKGTDLTRAAAAALRRAPIDFVGYCEGRDLLTGEVDVIVTDGFTGNVALKTMEGTAKVVGEYLKRALRSTTVSKIGGLLSKAALEGMKKRIDWREVGGAPLVGVNGVGFISHGRSDALAVENAIRRAGDAARTHFIDEIARAVAPSHALLEVPADGAAAEQGPTPRRTAPRQT
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: TBA1_DROME
Sequence: MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSGDGEGEGAEEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-1 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: NTH2_YEAST
Sequence: MREESRSRKRKHIPVDIEEVEVRSKYFKKNERTVELVKENKINKDLQNYGGVNIDWIKALKPIEYFEWIESRTCDDPRTWGRPITKEEMINDSGAKVPESFLPIYNRVRLMRSKVKTPVDAMGCSMIPVLVSNKCGIPSEKVDPKNFRLQFLIGTMLSAQTRDERMAQAALNITEYCLNTLKIAEGITLDGLLKIDEPVLANLIRCVSFYTRKANFIKRTAQLLVDNFDSDIPYDIEGILSLPGVGPKMGYLTLQKGWGLIAGICVDVHVHRLCKMWNWVDPIKCKTAEHTRKELQVWLPHSLWYEINTVLVGFGQLICMARGKRCDLCLANDVCNARNEKLIESSKFHQLEDKEDIEKVYSHWLDTVTNGITTERHKKK
What is the function of this protein?
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage.  The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site.  The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination.  Primarily recognizes and repairs oxidative base damage of pyrimidines, but also purine-derived lesions, alkylation damage as well as abasic sites.  Can also repair the oxidation products of 8-oxoguanine.
What are the official names of this protein?
Endonuclease III homolog 2, Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2, DNA glycosylase/AP lyase 2, Endonuclease III-like glycosylase 2, Redoxyendonuclease 2.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
What are the subcellular locations of this protein?
Nucleus. Note=Exclusively nuclear and not responsive to changes in either nuclear or mitochondrial oxidative stress.
Protein: DDL_THEAB
Sequence: MINVGLLFGSKSVEHEISIITAHQVLSFVDKNKYNIIPIYITKDGKWLTGKILEDLENFKNLERLEKKSKQISSISAKDGKLILHSNIKKITIDVCLLTFHGSNGEDGSIQGMLEFLNVPYTGCGMYSSMYTMDKVITKLILKEKNIPVVDFLYTNKKNYTNDFLNHCKEVLEYPMIVKPARLGSSIGVKKVNDKCELEEAIETAFSFDDKVIVEKWIDSRELNCAVMGYKNIVVSEIEEIKKQKDFFDYNEKYVQKGKKFSNHIIPAPIDENLKNTIKSIARDTFNALECHGNIRIDFLLSKDNKIYVNEVNSIPGALSYYLWQMSGFTFSQVIDNMISIAFEAFKDKKSKIYSIDTNLFDLKVEK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISK4_HUMAN
Sequence: MAVRQWVIALALAALLVVDREVPVAAGKLPFSRMPICEHMVESPTCSQMSNLVCGTDGLTYTNECQLCLARIKTKQDIQIMKDGKC
What are the official names of this protein?
Serine protease inhibitor Kazal-type 4, Peptide PEC-60 homolog.
What are the subcellular locations of this protein?
Secreted.
Protein: KTHY_RICRS
Sequence: MNNLKQGKFITFEGGEGIGKSTQSQMLYEYLQSQNTPVILTREVGGTIVAEKMREILVHEELLPMSELFQAMAARYDHMARKIIPALQEGHIVICDRFIDSTVCYQGLELENGIDLVYNLHKTLMPSLMPDITFFIDVEPDTAIKRVNSRNMNNKFDIRGIDFYKKIYYCFKELSNRFPERIKTIKASDLSPLEVHELIKKHL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: ISCS_COLP3
Sequence: MKLPIYFDYSATTPVDKRVAEKMMQYMTNDGHFGNPASRSHKFGWQAEEAVDIARNQIAELINADPREIVFTSGATESNNLAIKGAANFYNKKGKHIITCKTEHKAVLDTCRELERQGFEVTYLDPEENGLIDLNKLNDAMRDDTILVSIMQVNNEIGVIQDISEIGEMCRARKIVFHVDAAQSAGKINIDMQALKVDLMSISAHKMYGPKGIGALYVSRKPRIRLEAQTHGGGHERGMRSGTLATHQIVGMGEACRLAKEEMAQDQAHVTAMRDRLWAGLNSMEQVFINGDADKRYPGNLNVSFNFVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGLNDEMAHSSIRFSFGRFTTTEEIDYAIELIKGAIGHLRDMSPLWEMFKDGIDLDSIEWAAH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_SHEON
Sequence: MKIGIIGAMEPEVAHLIAAMTNTSSQTIADIEFIAGTLAGKDVVVTRSGIGKVAASIATTLLIEKYAPDAVINTGSAGGFVDSLSIGDIVISSEVRHHDVDVTAFGYEIGQMAQQPAAFIPAPYLVEAANKAIAQLGEVRAIEGLICTGDSFICDPVRTKTMLEHFPTMAACEMEGAAIAQVCHQFGVPFVVIRSLSDNANNDSPVDFDAYIVKAGYHSALMVMLLLEQLEPNSVK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: ATP6_YERPS
Sequence: MSASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFLLVFRKVAASATSGVPGKLQTAVELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNMMDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGVFILIIFYSIKMKGVGGFTKELTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWMLSVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.