PharMolix/UniProtQA huggingface dataset:
Protein: NUOK_ECO81
Sequence: MIPLQHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YD042_YEAST
Sequence: MEQILYNQSLKISTLSTFQGLKFLKVLIFSIFQQLFYNPVIQLFGTKASIMESDSTTLLESSWSTERNFLNMNSDSISATKNVFILFFTIFRLAEYIVYKLSDQKYRLHTSLNVQHFRWNSKKNTNRKRTLSFSKAYLPRTNILPIFVADGLKNRFSGPLPGKSLESFQKLNLLSDNNIKRYAVPGNKAVNTLLWQEQYS
What are the official names of this protein?
Uncharacterized protein YDR042C.
Protein: TUBE_DROVI
Sequence: MEMAKANGWAVVCTSTNTNTVPIYSKYTRCTELRRVDDNDIYKLATILDVNGCWRKLMSIIPKRLDAQACSAPGALNYQEIAAKVGLKYTAQQISLIDGTAERLTPGQSISQVMIDEWKTSGKLNERPTVGVLLQLLVHAEIYSAADFVALHFLNEPKPERPTDGPAAHISLDLCSEDLSEDMDVEDGASYQPNTSALNAAVEQARGTGMNLDYFDKHMVRRDKSVPQQLENGTSSTVPVPPPRAARSSRLLKATASNVAPTTASNAPSASNTANVPNLSILNASSKKLAASSEQTLQPQNIPNLSILNGSSEAVLMATTSTTLDAGKSDNASNGRSSASTSTATIPNVPLITLLIENSSCEISDASDATQITSKSTATKTVPDMSTASYNNLPAISALNLNIASGAGELDGNGAKARGDNADNNSSGTNSLSNDDDEQKEDDDDDDDDDVVDVDDEEADVSLPNLSNSDHNDSSLTTVTCTSGENSFEFTNDSSSASNDDYTNNIPNLSELQQ
What is the function of this protein?
Required for the determination of embryonic dorsoventral polarity.  Is involved in transduction of information regulating nuclear import of dorsal protein.
What are the official names of this protein?
Protein Tube.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PELO_METMA
Sequence: MRVTNRSLKGREGEIAVTAETLDDLWHLKYIIEKGDMVFALTRRKADSASDKLRPEKVEKVKVRLGIRVEELEFHKFANRLRIHGPIEHGMDTGSYHTLNVEIGTNISIIKEHWKNDQLQRIQDAEEAGKRPKVVIVAVEEGDADIGFVRHYGIEVYSHIRQSSGKRETGLRNEFFREIVEQLRHAVPEDASIVIAGPGFTKEDFLKYFNETESEMASKALTEDTSMIGMSGFQEVLRRGAVDRIMQESRIARESSLMEDLIREISMDGKAAYGFADVKNALGYGAVETLLIADETLREGREKGEDIDKLLMEVEQAQGKVVVFSTAFEPGEKLHKLGGIAALLRFKVTG
What is the function of this protein?
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA.  May play a role in the release non-functional ribosomes and degradation of damaged mRNAs.  Has endoribonuclease activity.
What are the official names of this protein?
Protein pelota homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBA2_TRIEI
Sequence: MTTTLQQRENANVWERFCSWVTSTDNRIYVGWFGVLMIPTLLTATICYIIAFVAAPPVDIDGIREPVAGSLMFGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPYQLVIFHFLIGIFTYMGREWELSYRLGMRPWICVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLVRETTETESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLGAWPVVGIWFTALGVSTMAFNLNGFNFNQSIIDSSGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEAPSIKG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1 2, PSII D1 protein 2, Photosystem II Q(B) protein 2.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: FLIM_THEMA
Sequence: MSDVLSQEEINQLIEALMKGELKEEDLLKEEEEKKVKPYDFKRPSKFSKEQLRTFQMIHENFGRALSTYLSGRLRTFVDVEISIDQLTYEEFIRSVMIPSFIVIFTGDVFEGSAIFEMRLDLFYTMLDIIMGGPGENPPNRPPTEIETSIMRKEVTNMLTLLAQAWSDFQYFIPSIENVETNPQFVQIVPPNEIVLLVTASVSWGEFTSFINVCWPFSLLEPLLEKLSDRFWMMGRKPEKVEERMEELRKASQKIPVTVQAVIGETELRLKEILDLEVGDVIRLGTHYKDEIRIDVEGRPKFRGIPGVFKGKYAVKVTGEFTNGGEYE
What is the function of this protein?
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body.  This complex interacts with the CheY and CheX chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
What are the official names of this protein?
Flagellar motor switch protein FliM.
What is the protein family that this protein belongs to?
Belongs to the FliM family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein. Bacterial flagellum basal body.
Protein: NDK_METJA
Sequence: MKERTFVALKPDAVKRKLIGKIIERFENKGFEIVAMKMIKLDREMAEKYYEEHKGKEFYERLINFMTSGRMIVMVVEGENAISVVRKMIGKTNPAEAEPGTIRGDFALTTPDNIIHASDSKESAEREIKLFFKEDEIFDK
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTLD_LACCB
Sequence: MEAVHFGAGNIGRGFIGETLAANGFKINFVDVNETIINALNQRGEYTITLAAPGEKKIHVDNVDGLNNAKDPEAVVKAIAQADLVTTAIGPKILPIIAPLIAQGLQARDAANNHQALDVIACENMIGGSQSLKKSVYEHLDDAGKTFADTYVGFPNAAVDRIVPQQKHDDPLAVSVEDFKEWVVDESQMKNKDLKLKTVDYVPDLEPYIERKLFSVNTGHATTAYTGKYLGYTTIGDAIKDPKVFNQAKGALAETRSLLLSEFKNFDEKDLENYQNRVLQRFQNPYISDDISRVARTPIRKLGYDERFIRPIRELKERGLNYSVLMDTVGMMFHYVEPNDAEAVKLQAMLKDQPLVDVIKEVTGLKDAGLIDEVEASVKSKDR
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: RECO_ECOL6
Sequence: MEGWQRAFVLHSRPWSETSLMLDVFTEESGRVRLVAKGARSKRSTLKGALQPFTPLLLRFGGRGEVKTLRSAEAVSLALPLSGITLYSGLYINELLSRVLEYETRFSELFFDYLHCIQSLAGVTGTPEPALRRFELALLGHLGYGVNFTHCAGSGEPVDDTMTYRYREEKGFIASVVIDNKTFTGRQLKALNAREFPDADTLRAAKRFTRMALKPYLGGKPLKSRELFRQFMPKRTVKTHYE
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: CD2AP_HUMAN
Sequence: MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLSS
What is the function of this protein?
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567).  In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival.  Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity).  May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity).  May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus.  Also required for cytokinesis (PubMed:15800069).  Plays a role in epithelial cell junctions formation (PubMed:22891260).
What are the official names of this protein?
CD2-associated protein, Adapter protein CMS, Cas ligand with multiple SH3 domains.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell junction. Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles (PubMed:10339567). Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase (PubMed:15800069).
Protein: AIMP2_CRIGR
Sequence: MPMYQVKSYHGGSAPLRVELPTCMYRLPNVHSKTTSPATDAGHVQETSEPSLQALESRQDDILKRLYELKAAVDGLSKMIHTPDADLDVTNILQADEPVPLTTNALDLNLVLGKDYGALKDIVINANPASPPISLLVLHRLLCERYRVLSTVHTHSSVKNVPENLLKCFGEQARKQSRHEYQLGFTLIWKNVPKTQMKFSVQTMCPIEGEGNIARFLFSLFGQKHSAVNLTLIDSWVDIAMFQLKEGSSKERAAVFRSMNSALGKSPWLVGNELTVADVVLWSVLQQTGDGSGVAPANVQRWLKSCENLVPFSTALQLLK
What is the function of this protein?
Required for assembly and stability of the aminoacyl-tRNA synthase complex.  Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation.  Blocks MDM2-mediated ubiquitination and degradation of p53/TP53.  Functions as a proapoptotic factor.
What are the official names of this protein?
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38, Protein JTV-1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
Protein: H3_DERIM
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTELRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3, embryonic.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CWP24_SOLLC
Sequence: HPVEI
What are the official names of this protein?
42 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: ANR61_RAT
Sequence: MGNITKRGSRDFAADSAVLLEGSLATALHSRLYEAIIKEDCDTIRTLLRNHPVNQPLTLLASSTGYRFLSQQTQPIFPIHLAAEYRKPQSLLCLLQHGADPEVRDAQGLTTLHLMLLNWPVTSTTWTKPSTRIQKILTDIQNNAVLCLRILCDHGAQVNARVDNSNKHSPLHLAITYGTYPVLSFLAQNGAQVNAINESSMTPLHMAADILNKNMIETLIACGANVNCAISSTGNTALKLAVCTASSKAGRLLAAGVGCIRLLLNHGAQVNAQDHEGQTALHEACFGGREVIINLLLEFEANVNILTRNGESPIYMYLQRSSNIRDVTLLARLLYRTYPLRLSNKQGALPAGIMLPEFHLLRETLIKLSKKPLTLEAICKRNIRNVYGEKYKFQLKKLLPAKLWNSIYGIYDFTYLLK
What are the official names of this protein?
Ankyrin repeat domain-containing protein 61.
Protein: ODR4_CAEEL
Sequence: MTRNRRKSKTTATSHPELHLEKVDPMKTVTESMILFDVQLQEWVTKSAKNHEFVLSDKGIPASAYFLLGSFCSDGDIHVAYASKCPVHSSALEENATESSKMLEDEWMSDHAERLLRMLPGGIHVVGIAWFSDKKTFSDRKSHIHKTLGRIQKMNNQITTANVDDSISDNMITVFFETPSTTPIGAIIDVTNRGNDSAQKVQFQKLEWISLVTNASARIVHNVPVDTGRPTDFYSDLVVATKNFVNNLFQCEFTLLDGEIRDDKEPLIKDIKKNKKTTIEAQLFLNPLYNRELGAIDDIASNMHEVLFDIEVRAAVPIRSTVKDAIRAIKHHLVRNLFARVELHYESMEVVEEERSPKTGITVHQLPRPATTVLYTHPAILINDFLFEADNVEDAQKNFDDMMDLQTSIEHVDEGWERALTPEEMEAVRTPIEDLHFVDFDGSSDSWCTTKTILITIALIIGLLASIIYFTVAHS
What is the function of this protein?
Required, with oct-8, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC (PubMed:9590179, PubMed:24603482).  Regulates chemotaxis responses to benzaldehyde, diacetyl and 2,4,5-trimethylthiazole in AWA and AWC neurons (PubMed:8348618).  Plays a role in nociceptive neurons to mediate avoidance of high oxygen (PubMed:16581509).
What are the official names of this protein?
Odorant response abnormal protein 4.
What is the protein family that this protein belongs to?
Belongs to the ODR-4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Note=Punctate expression in dendrite and axons.
Protein: ATI2C_ALYOB
Sequence: ILGAILPLVSGLLSSKL
What is the function of this protein?
Shows more potent growth inhibitory activity against the Gram-positive bacteria S. aureus (MIC=50 uM) than against the Gram-negative bacteria E. coli (MIC=150 uM).  Has a weak hemolytic activity against human erythrocytes (LC(50)=135 uM).
What are the official names of this protein?
Alyteserin-2c.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Alyteserin-2 subfamily.
Protein: RL19_MYCPU
Sequence: MKNKLLQLVEQNQIRKDLPNFNTGDNVKVHLRIKEENKERIQIFEGLVIAKDGPGKGLSQSFKVRKISSGIGVEKDFPLNSPIISAIEVIRRNKVRRKKLYYIRNKSGKSARLKEKK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: MUKF_HAEAE
Sequence: MIETSQTIPELVSWAKDREFSLNLPTERLVFLLAIAIYNNERLDGEMLEADLVDIFRHTMNAFEQSTDAIATRANNAINELVNNVVNRFSSEFTEGLAIYRLTPLGVGVSDYYIRQREFSALRLSVQLSIVADEIQRASDSAEEGVENNESEHFWRRNVFAPLKYSVAEIFDSIDLSQRIMDENQQSIKDEIAELLTKDWQAAISSCERLLDETSGNLRELQDTLNAAGDKLQAQLLRIQDCVIGRDDLYFIDQLITDLQSKLDRIISWGQQAIDLWIGYDRHVHKFIRTAIDMDKNRVFSQRLRNSIHHYFDHPWFLWTAQAERLVDLRDEEMVLREDDALGELPEELQYESLSDLHDQIVEHMQGLLIAYRENNRPIDLSLVLKEQLENYPLSRHFDVARIIVDQAVRLGMANDDLSGIYPDWQAINKRGAEVQAHVIDKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: PLPL7_HUMAN
Sequence: MEEEKDDSPQLTGIAVGALLALALVGVLILFMFRRLRQFRQAQPTPQYRFRKRDKVMFYGRKIMRKVTTLPNTLVENTALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDPSICVVQDGRLEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIPLVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAGPLLKRSHSVPAPSIRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGLPTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFSRRSLPKLVEMYKHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHGRTVFDIWGRSGVLEKMLRDQQGPSKKPASAVLTCPNASFTDLAEIVSRIEPAKPAMVDDESDYQTEYEEELLDVPRDAYADFQSTSAQQGSDLEDESSLRHRHPSLAFPKLSEGSSDQDG
What is the function of this protein?
Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine.  Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0).
What are the official names of this protein?
Patatin-like phospholipase domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Lipid droplet.
Protein: DADA_CHRVO
Sequence: MKVIVLGGGVLGVSTAWYLAKAGCQVTVLERQDGVALETSFGNAGQISPGYSAPWAAPGIPLKGLKWMFQRHAPLAITPDGSLYQLQWIAKMLANCNEKAYAVNKGRMMRLAEYSRDKIKELRAETGLQYEGRQGGTLQLLRSQAQVEGMAKDIAVLRECGVDFNVLDPDGCARVEPALAAVKHKLAGGLQLPNDETGDCNLFTSRLAELARDKGVEFRFGVTVDGIENDGKRITGVRIGDELLRADHYVVAMGSYSRDMVKELGIDIPVYPVKGYSLTVPITNPDGAPTSTILDETYKVAITRFDNRIRVGGMAELSGYNLELNPRRRETLEMVVGDLYPNGGDIKAASFWTGLRPMTPDGTPIIGGTRFANLSLNTGHGTLGWTMCAGSGKVLADIITGAKPEISVDGLSMQRYAKQGETLVVPVIRPAVQGA
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: Y459_NEIMB
Sequence: MSNWKPNIPYNDLPPLPPKQDIESKTILKRCIAARASLARLKQAAELIPNQAMLINTLPVMEARASSEIENIVTTTDKLFQSLQMDTERQDPATKEALQYRTALFAGYESLTSRPLCTQTAIMVCNAIKHPYEMAIRKTGGTALKGGNSGNVVYTPPEGEETIRGKLANWERFIHESGDLDPLIIMAAAHYQFEAIHPFTDGNGRTGRILNSLLLIEKGLLDLPILYLSRYIIENRADYYRLLLGVTERQDWESWIIYILDGVADTADWTVSKIDAIRRLFEQTRQHIRTHAQGIYTHELVNLLFEQPYTRIANLEAAGIAKRQTASKYLKELSDIGVLQEIVIGRDKLFIHPRLMELLRGEGNSFTSF
What are the official names of this protein?
Uncharacterized protein NMB0459.
Protein: OBG_STRMU
Sequence: MSMFLDTAKVSVKAGRGGDGMVAFRREKYVANGGPWGGDGGRGGDVIFVVNEGLRTLMDFRYNRHFKAKAGEKGMTKGMHGRGAENLYVSVPQGTTVRDAQTGKVIADLVKNGQEFIVAHGGRGGRGNIRFATPRNPAPEISENGEPGEERELALELKILADVGLVGFPSVGKSTLLSVITAAKPKIGAYHFTTIVPNLGMVRTKSGDSFAVADLPGLIEGASQGVGLGTQFLRHIERTRVILHVIDMSASEGRDPYEDYLAINKELETYNLRLLERPQIIVANKMDMPQAAENLEQFKEKLDANYGEFDDKPQIFPISGIAHQGLDALLDATAQLLAQTDDFLLYDESDMQEEAYYGFEEEEKAFDISRADDAAWVLSGEKLEKLFVMTNMERDEAIMKFSRQLRGMGVDQALRERGAKDGDIVRIGKFEFEFVD
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F118B_RAT
Sequence: MASTGSQASDIDKIFGFFNDGEPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGNDYADLPEYFKRLTCEISTRGRSGMAREGQLNGSSAAHGEIRGCST
What is the function of this protein?
May play a role in Cajal bodies formation.
What are the official names of this protein?
Protein FAM118B.
What is the protein family that this protein belongs to?
Belongs to the FAM118 family.
What are the subcellular locations of this protein?
Nucleus, Cajal body.
Protein: TMM88_MOUSE
Sequence: MAEVPGAQRPVLAGGPEPRDPLDCWACAVLVTAQNLLVAVFNLLLLALVLGTILLPAVIMLGFGFLCHSQFLRSQAPLCTSHLRDPGFTALLVTGFLLLVPLLVLALATYRRLCLRLRLADCLVPYSRALYRRRRIPQPKQIPVSPGSRSVPTPGKVWV
What is the function of this protein?
Inhibits the Wnt/beta-catenin signaling pathway.  Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity).
What are the official names of this protein?
Transmembrane protein 88.
What is the protein family that this protein belongs to?
Belongs to the TMEM88 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RFP4A_DANRE
Sequence: MDGNVFPDQEQLLAFLKKLKEVFDVCDEDADGYIRVEHFVDLGLQFGQGDEVKKFAKYLDPNAHGRINFKDFCHGVFAIKGCEEILKSALGTPTIAAQPYQTDNGYYYQHQEGSLGPPIIVCTRPYPECQLYSDEEGMGGRDMQESDMDSAADSGAGSESSEGGRQDDKEEGLGGFFLRGNNCGQMVSSAAASVISVEEQFEDYGEGEDVDFTPSSPIPDDDTRTNGFSDLGSSLPSSAGQTPQKIRHLYNSELLDVYCSQCCKKVNLLNDLEARLKNLKANSPNRKISSTAFGRQLFHHSNFSSSQGSTEDLFRDSIDSCDVDITEKVSYLEKKISELENDSLANGDLKSKLKQENTQLVHRVHELEEQIKDQETRAEQCLEEELKRHREAYSKMERDKSTEIELLSNRVQQLEEENAEMKVNVCRLKSQTEKLDQEKQRMTDKLEDTSLRLKDEMDLYRKMMDKLWQNRHEFQKEREAMQELIEDLRRELEHLQLFKLETEKPGRGRTAAGLSEYNAKTREIELEHEVKRLKQENHKLRDQNDDLNGQILSLSLYEAKNLFACHTKAQSLAAEIDNASRDELVDALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH
What is the function of this protein?
Acts as a regulator of endocytic traffic by participating in membrane delivery.  Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity).  May play a role in differentiation during retinal development.
What are the official names of this protein?
Rab11 family-interacting protein 4A, FIP4-Rab11, Rab11-FIP4-A, zRab11-FIP4-A.
What are the subcellular locations of this protein?
Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle. Note=Recruited to the cleavage furrow and the midbody during cytokinesis.
Protein: KTHY_ECOUT
Sequence: MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVGDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLATLRDAVLGGFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQDKSIHTIDATQPLEAVMDAIRTTVTNWVKELDA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RCNA_ECOL6
Sequence: MTEFTTLLQQGNAWFFIPSAILLGALHGLEPGHSKTMMAAFIIAIKGTIKQAVMLGLAATISHTAVVWLIAFGGMVISKRFTAQSAEPWLQLISAVIIISTAFWMFWRTWRGERNWLENMHEHDHEHHHHDHEDHHDHGHHHHHEHGEYQDAHARAHANDIKRRFDGREVTNWQILLFGLTGGLIPCPAAITVLLICIQLKALTLGATLVVSFSLGLALTLVTVGVGAAISVQQVAKRWSGFNTLAKRAPYFSSLLIGLVGVYMGVHGFMGIMR
What is the function of this protein?
Efflux system for nickel and cobalt.
What are the official names of this protein?
Nickel/cobalt efflux system RcnA.
What is the protein family that this protein belongs to?
Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.