PharMolix/UniProtQA huggingface dataset:
Protein: SED4_YEAST
Sequence: MSGNSANYDVGYPIYGAKFINEGTLLVAGGGGQFNSSFPNKITALKVNFQKKKHIRRFREITLDSIDDAPTSLDCNNNLILVGCNELFNDSSMENVNHHLRKFVFEQEHLKFVASIDFNRTTDPSVFTKFVYINQRATVAAIASSEVPTVIRIIDPRNLTENYEIETGREVNDLHFAPNGILLSYITSNSLEVASVRDGNFVARKTDFDKNLVLSNIRFLNDNTLLVAASLSNSDGVSLLKLGVSSKGVKILKTASFMFDLNGITSMDVSPNKKFVALSSNDNLVAIVSVEKLKLVQLVPRVHESTITKVTFSPDSRYLASTSMGNTINVLKLSGTSSSILRNIWKFFLNFVLLVVLAGAIQLGYKHNVHGFIYKHAHDIYKSKFKENTTIDQGSSSYFTINDDYRGITESADIISATDVASDIETEFSSFDTSTMRTTTEDEQKFVWISSSADSQFTSADIPTSASSSSSSSSSSFYEESVTNEPIVSSPTSEITKPLASPTEPNIVEKPSLPLNSESIDLLSSSSNSITEYPEPTPDLEEKLSSLIVEQSESEITTDRESVSKLLSTESPSLSHMPSSSSSSLSLSSSLTTSPTTALSTSTATAVTTTQTNPTNDAANTSFLDNSKPASTREIYKTKIITEVITKIEYRNIPASDSNAEAEQYVTTSSSMLLTPTDTMVSSPVSEIDPIASELERMVETPTHSISIASEFDSVASNLIPNEEILSTSASQDSISSHPSTFSDSSITSGFQSIEVSTVTSSVLASESIPSISDSTFSKFHSISEPVSSAIVETATSSFSKTETKTSRVIAFSTEDSERSSALIDNSEYTSVLADNLEPTSVLADNSEPTSVLADSSEPTSVFTDAVQSPKTSVGQSSLSESTNIEGTSMASMIFSSSGASIGALSDIGKGTLSVESASSTVAQPMPGVTTTAPSFVSSPHKISASSIDASGFVQKEIMIEVQSSKDSSEAFGVRHKISENVNTPVSRMLTTEMQASGTVDVTEDVSLSSEVISALNVEITSLPNPVAPPQTIAAPLNNNSNTNIVNDDNAVAGTVNYAGLHDEL
What is the function of this protein?
Putative guanine nucleotide-exchange factor (GEF) involved in the formation or budding of transport vesicles from the ER.  Positive regulator of SAR1 probably through inhibition of the GTPase activation by SEC23.
What are the official names of this protein?
Putative guanine nucleotide-exchange factor SED4.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC12 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single- pass type II membrane protein. Note=In the process of transport, SED4 itself may migrate to the Golgi apparatus and function in subsequent transport events.
Protein: MRAZ_SHEDO
Sequence: MFRGASAINMDAKGRIAIPMRYRDQLHVHGTGVIVITIDIQSQCLLIYPLQEWELIEAKLLTLSDTNPVERSFKRRLLGHAHECELDSHGRVLVPPTLRQYAGLDKKAMLVGLLNKFELWDEAAWQQQMDDSQTLIQSQDLSSQDRLADFSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: TRHO_STAES
Sequence: MDYRVLLYYKYVTIDDPETFAAEHLKFCKEHHLKGRILVSTEGINGTLSGTKEDTDKYIEHMHADNRFADLTFKIDEAESHAFKKMHVRPRREIVALDLEEDINPREITGKYYSPKEFKAALEDENTVILDARNDYEYDLGHFRGAIRPDITRFRDLPEWVRNNKEQLDGKNIVTYCTGGIRCEKFSGWLVKEGFENVGQLHGGIATYGKDPETKGQYWDGKMYVFDERISVDVNQIDKTVIGKEHFDGTPCERYINCANPECNKQILVSEENEEKYLGACSYDCAKHERNRYVARHHISNEEWQRRLNNFKDVPEHTHA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: TGT_BORGP
Sequence: MFSVIKNDKHSNARVGFLNLPHGRVDTPCFMPVGTLGAMKGLKHSVLEKLKCNLMLANTYHLYLRPGIKTIEKYGGLHNFTTWNKNFLTDSGGFQVFSLSSLRKIDLKGVRFKSHLDGSYHYFTPEGVFAMQEIFGSDIIMPLDICSSYGIDYNEANLYTNITTNWARSTFKAYKNRKEGYNGLLFLITQGNFFKDLRKRSINDILELDSPGIAIGGISVGEPREKYLEILEYSSLLMPKEKPRYVMGIGTPHYILDAIYHGIDIFDCVNPARIARHGSLLTDNGIMRISRKEYKDDTSQVEKNCGCTLCTRYSRGYLRHLIKSKELFGIILASEHNIYYMFRLISKIRTAILNDNFLNFRTSYLKKYEEENFDE
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RRAA_YERPS
Sequence: MKYDTSDLCDIYHEEVNVVEPLFSNFGGRTSFGGKITTVKCFEDNGLLFDLLEENGLGRVLVVDGGGSVRRALINAELAELALKNEWEGIVVYGAVRQVDDLAELDIGIQAMAAIPVGAADEGVGESDIRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSRG_YERP3
Sequence: MHVTLVEINVKEDKVDQFIEVFRANHLGSIREAGNLRFDVLRDEHIPTRFYIYEAYTDEAAVAIHKTTPHYLQCVEQLAPLMTGPRKKTVFIGLMP
What is the function of this protein?
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.  Catalyzes the conversion of (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5-phosphonooxypentane-2,4-dione (P-HPD).
What are the official names of this protein?
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase, Autoinducer 2-degrading protein LsrG, AI-2-degrading protein LsrG, Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase, Phospho-AI-2 isomerase.
What is the protein family that this protein belongs to?
Belongs to the LsrG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_META1
Sequence: MKKIYVAGGCFWGVQGFLKTIKGIKKTTVGYANSLLENPTYELVKSHVTDAVETVEVIYDENILSLKDIVKKLFAVIDPTARNYQGPDHGRQYRNGFYFVDQEDGVMLRELMLEFSKKYEKPLATEILPLDNYYLAEDYHQDYFDKHPNAVCHIKF
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: FLGI_RUEPO
Sequence: MTLIRLLACLLFLPCLAQAGAVRLKDLVEFDGVRGNDLVGYGLVVGLNGTGDGLRNAPFTEEIMSNILERLGVNVTGEDFRPKNVAAVFVTAALPPFARVGSQIDITVSAIGDSKSLLGGTLIMTPLNAADGQIYAVAQGTVLAGGASAEGQAASVVQGVPTSGVIPAGARVEREIEFDLGSLTQLRLALREPDFTTAGRIETAVNSAFNGRVAVMRDSGTVELDIAATQARSPAHVIGRIENILVEPERKARVVVDQRSGTIVMGADVRISRVAVSQGSLTLRVEEAPIAVQPNPFADGDTVVVPRTNAEIEQEPGIKLAEVPESASLSDVVAGLNALGVSPRDMIDILKTIKAAGALHAEFVVR
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: GLMU_NEIM0
Sequence: MPQNTLNIVILAAGKGTRMYSKMPKVLHRIGGKPMLGRVIDTAAALNPQNICVVVGHGKEQVLDTVKRDVVWVEQTEQLGTGHAVKTALPHLAAEGRTLVLYGDVPLIDVETLKTLLEAAGDKVGLLTDVPTDPTGLGRIIRDGNGSVTAIVEEKDASTAQKAVKETNTGILVLPNAKLENWLNSLSSNNAQGEYYLTDLIAKAVSDGIKVRPVRVRASHLAAGVNNKLQLAELERIFQTGQAQELLKAGVTLHDPARFDLRGRLKHGQDVVIDANCIFEGEIELGDNVEIGASCVIKNAKIGANTKIAPFSHLEDCEVGENNRIGPYARLRPQARLADDVHVGNFVEIKNAAIGKGTKANHLTYIGDAEVGSKTNFGAGTIIANYDGVHKHKTVIGNEVRIGSNCVLVAPVTLGNKVTTGAGSAITRNVEDGKLALARARQTVIEGWVRPEKDKQ
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_CHAVU
Sequence: MKFEKNTDIFILPDFIRIQLESFHRFIEKGLLEEFQRFPVIRDSSGELSYFLNGKRYKLQEPSFNEQEAIYQASTYSSELYVPAQITHTKSEKTKSEIILIGNIPIMTARGNFIINGASRVIVNQILRSPGLYYGSELDAQANITYSCTFISEWGGRLKLEMDNKRRIWVRLSKKRKIPVLLLLLAMGLNWKDLEKLISRPSLLLSYLSKEKRTPYSPEEAIIELYRHSCSVSGEISFSENIRKELYHKFFKIRCEIGSIGRLNINKKLNLDIPEEERFLVPQDLIAAINSLIEKSFKIVNLDDIDHLKNRRVHLIADMLQSQVRIALNRLKRMIAEVMRGINKRKNLPNPQSLVTPKPLVATFQEFFGSHPLCQFMDQTNPLAEITHKRRISSLGPGGLTQKTATFNVRDIHPSHYGKICPIETPEGQNAGLVSSLAILANINQNGFIESPFLKLHKNEYKQLTGSEHLCSEQEEYYRITTGEHSRETAEKKGKPTPIRYRQEFSATAFHFLHFRDILPIQYFSIATSLIPFLEHDDANRALMGSNMQRQAVPLLRPEKPIVGTGLEGQVALDSAALVLSKIEGKVDFVDGRNINIRSNIVINEFFSFQLINYERSNQNTCLHQKPIVKKDDYVKKGELLADASSTLGGEISLGNNILVAYMPWEGYNFEDAVLINERLIYEDIYTSIHIEKYEIEVNMTSLGPEKITKKIPHLSEYLLRNLDVNGLILLGSWVKTGDVLVGKLTPREPGESLRLPEGRLLHAIFGIKASSFFETCLKVAPGAEGRVIDVRWVESANKLTQKYIKTVNIYILQKRKIQVGDKIAGRHGNKGVISRILPREDMPYIQDGTPIDMVLSPLGVPSRMNLGQIFECLLGLAGESLKKHYRIMPFDERHEREASRKLAFSELYQAKKFTGHSWLFEPDTPGKSQLFDGRTGQTFENAITVGKAYILKLIHQVDDKIHARSTGPYSMVTQQPLGGKARRGGQRMGEMEVWALEGFGAAYTLQELLTRKSDDMKGRNEALGAIVTGNLIPKPNTTPESFKLLMRELRCLCLNIHHCSLFQENLSMKNIEF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MER_ERYCB
Sequence: MERQVPRVLLNSGHEMPVIGFGTAIDPLPEPEQLVSAILHAIEVGYRHFDTASAYMTEEPVGRAISEAMKRGLIKGREELFVTSKLWCADAHRDLIIPALKETLKRLGLDYLDLYLIHFPVRLKKEAVSLEHEIDDFRFEDHELLPFDIKGTWEAMEECSRLGLTKSIGVSNYGTVKISQLLQHATIPPAVNQVEMNVAWQQKKLREFCSKKGIHVTAWSPLAGIGAFWGSTVVIESKTLKEIAAAKGKSVAQVALRWIQDQGASCIVKSMNKDRMKQNLEIFGWKLSDEDGRKIEQIKQSRLYPAKLFINENSPYPSLEALWDGDL
What is the function of this protein?
Catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.  Can also use 6-hydroxytropinone, tropinone and nortropinone as substrates, but not 8-thiabicyclo[3. 2. 1]octan-3-one (TBON), cyclohexanone, cyclooctanone or N-methyl-4-piperidone.  NADH can substitute for NADPH, but with a decreased activity.
What are the official names of this protein?
Methylecgonone reductase, MecgoR.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: MURB_PROMT
Sequence: MNSIKLEKNISLSNFTTWGIGGPAEWIAQPKNIEELKYVINWTNKKKIPCSVIGAGSNLLINDKGIKGLSLCMRNFKGIEIDKNNGIIEVLSGEMLPTLARKAAASGLHGFEWAVGIPGTIGGAVVMNAGAQEHCISSYLESITTLSLTGEYQRIKGKDLNFGYRQSLLQNEKLIVVSARLKLASGHAKEIRQVTNENLNHRLKTQPYQAQTCGSVFRNPEPLKAAKLIEELGLKGFRFGGAEISKIHSNFIINANQASSNDVRELIKYVKKRVFDSYGILLETEVKQCGF
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS4_ERYLH
Sequence: MIVFPAIDLKGGEVVRLAEGDMDRATVYGDNPAAQAMLFAEAGAEHLHVVDLDGAFAGESRNREAVEAIVAEFPGYVQLGGGIRDATAVEGWFNLGVARIVIGSAALKDPDFVKEMAREWENGIVVAVDARDGMIATEGWAEVSDVPVADMARRFEDAGVASLLFTDIGRDGLLKGCNIDATVELARQTDMPVIASGGVKGLDDIHVLSLHAHEGIEGVITGRALYEGRLDLAAAIAMGARS
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT2A1_HUMAN
Sequence: MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWLMVLKISLPVIGLDEILKFVARNYLEDPEDERRK
What is the function of this protein?
Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum.  Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity).  Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677).
What are the official names of this protein?
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, SERCA1, SR Ca(2+)-ATPase 1, Calcium pump 1, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ISPF_KOSOT
Sequence: MYRVGIGFDAHPLEANKKGLYLGGVKVSEEYSSIGHSDGDALIHAIVDAILGATNAGNIGIWFPENEENRGRRSTEFLEIIRKKILAGKYEILNIDSVIIIDKVRMNPHIENIRLKLARILGISKGNINVKPKSGNTLYGNSVSVYAVCMLKKVGT
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RIMP_BACAC
Sequence: MDKKVTEVVEAFAQPIVEELNLELVDVEYVKEGQDWFLRVFIDSEKGVDIEECGAVSERLSEALDKEDPIPHLYFLDVSSPGAERPLKKEKDFQQAVGKQVAIKTYEPIDGEKMFEGKMLSYDGTTITLLLTIKTRKKEIQIPMDKVANARLAVTF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_DICT6
Sequence: MRRTHYCGEINIKNVGEKVSLSGWVHRIRHHGGLIFIDLRDRSGIVQLVVDPAISQESYNIADTLGNEWVISVEGKVRKRPEGMENPKIPTGEIEIEVEKINIENPSKPLPFNLWSNKEIDETVRLKYRYLDLRRDKMQSNIIFRHNFILAIRNFLAQNGFIEIETPYLIVSTPEGARDFIIPSRLQPGKFYALPQSPQLFKQILMVSGFDRYFQIARCFRDEDLRADRQPEFTQLDMEMSFVEIEDIFNIIENLFKTTLKNLMNIDITVPFPRITYEEAMNTYGSDKPDLRYDLKISDVTEIFKNLPLEFIRSTLEKNGVIKGIILKNIVPSRREWSIIENKVRELKGKGIMWFTYTDGELKSSISKYLDENTKNKLIENLNLREGDSFFCIAGEWKEVVKILGTLRLEIAELFNIEKKEGLYFLWVTDFPLFEYDEEERRIVAEHHPFTSPKDEDIPLLDTDPLKVKAKCYDLVLNGTELGSGSIRIHKKEIQEKVFNILNITPEDAKKKFGFLLEAFEYGAPPHGGIALGIDRIIAILTKSNSLRDVIAFPKTQSGTCLLTGAPSEVDSKQLEEVHIRVVYPEEKRKEEE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_PRIM1
Sequence: MGLIASAIAIGLAALGAGIGNGLIVSKTIEGTARQPEARGTLTSMMFVGVALVEALPIIAVVIAFMVQGK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: QOX2_STAAB
Sequence: MSKFKSLLLLFGTLILLSGCSNIEIFNAKGPVASSQKFLILYSIVFMLVICFVVLGMFAIFIYKYSYNKNAESGKMHHNAIIETIWFVIPIIIVAALAIPTVKTLYDYEKPPKSEKDPMVVYAVSAGYKWFFAYPDEHIETVNTLTIPKDRPVVFKLQAMDTMTSFWIPQLGGQKYAMTGMTMNWTLEASQTGTFRGRNSNFNGEGFSRQTFKVNAVSQKDYDKWVKEVKGKKTLDQDTFDKQLLPSTPNKALEFNGTHMAFVDPAADPEYIFYAYKRFNFELKDPNFTSEENMFKDVSEKPLIPARKAQITNANYKRHGMKLMILGNDEPYNNEFKKDESKNAKEMKKISKDAQDQDNDDHGGGH
What is the function of this protein?
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.  Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I (By similarity).
What are the official names of this protein?
Probable quinol oxidase subunit 2, Quinol oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MFND_METFA
Sequence: MILFFEYAIASGFEDEGILEEGKMMFNTLLNQFLEIDNVTSLIHKDFADDYKDFENLKIVEIEDDKDIEIKLNDILKNEKIDYALTIAPEDENILYNLTKIIEKYPVKNLGCSSNAIKVAGDKYLTYLTIKDYVKTPKTFKPKKYVIKKIDGCGGKFNLFDENFLIQEFVEGESLSVSLIVGKKIYPLSLNRQYIDERGFVGGEVNIKHRLKDEIFNEAIKAVKCIDGLNGYVGVDVIVNDEIYIIEINPRITTTIYGLKTEPSLAELLIKNANNEELTFKVEGKEFTINK
What is the function of this protein?
Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate.  The enzyme also accepts phenylethylamine in vitro.
What are the official names of this protein?
Tyramine--L-glutamate ligase.
Protein: IAP2_NPVOP
Sequence: MDLQRFNFLIMTTQGRVATMSFMSLDHAQKVDLAKTGLFFHNNLIKCIGCRATMDRVDARRVKRHTYSDTCVSAINALVANESLRKRSFASFKWARRQFGSRAREVDMLSRRGFYCVGKRLRCAGCKVVTTCVSVDGAQRAHAADCAFRRVFDVDLDACALANVVRVDLPPPRLEPRPSAPFDAAVSECKVCFVNEKSVCFLPCRHLVVCAECSPRCKRCCVCNGKIASRLSTIPQ
What are the official names of this protein?
Probable apoptosis inhibitor 2, IAP-2.
Protein: THIM_RHOE4
Sequence: MSDTVSVETVASAIDALRDQVPLVQSLTNIVSANFLTNVLLAAGASNAHIDNVHEAGGFAAVAGGVLVNLGTPDDGTAEAFLISAEAARTAGTPWVLDPVGVGGLPWRSGIAVDLLRFHPSAIRGNASEIIALAGLGGDTRGVDSASDSADAVPAALSLLTHADAVSASGPVDYIVGRDGGGDVRGIRVSGGSALLPRVTSTGCSLGGLVAAYLAVTPTALDGLVAAHTHVAVASEIAEENASGPGSFAVAYLDALYTVNADTIRSRARIESFDLPAGVQN
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: TSAD_LACLM
Sequence: MKDNYILAFETSCDETSVAILKNGSELLCNIIASQINSHKRFGGVVPEIASRHHVEQITVCIEAALEEAEISADQLTAVAVTEGPGLNGALLVGIMAAKTFAWANHLPLIPVNHMAGHLMAASLVDTIEYPAMALLVSGGHSELVYVEKEGSYKKVGETRDDAAGEAYDKVGRVMGLTYPSGKVIDELAHKGQDTYNFPRAMMNTHEVEFSFSGLKSAFINLVHNENQKGNDVIANDLENLAASFQVAVVDVLMAKTKLAMEKYPVKTLIIGGGVSANQGLRERLSAEITDEKLIIPPLRLCGDNAGMIAAAAYIEWKKGLENVQAGLDLNAKPSLVFEDM
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_CUPTR
Sequence: MKASMLAKLDQLAERLDEVNALLAREDATANIDQYRKLSREHAELSPVAEQYSQYRQAQDDLATAQALLDDPEMKDFAADEIAAARDRLEALQASLQRLLLPKDPNDDRNLLLEIRAGTGGEESALFAADLLRMYTRYAERQRWQVEVMSESESDLGGYKEVIIRIAGDAAFSRLKFESGGHRVQRVPATEAQGRIHTSACTVAVMPEADEVGEVEINPADLRIDTFRASGAGGQHVNKTDSAVRLTHLPTGIVVECQDDRSQHRNKDKAMKVLAARIKDMQTRAAQAREASTRRNLIGSGDRSDRIRTYNFPQGRVTDHRINLTLYKIDMIMDGDMDELLSALSAEHQADQLAALGEDA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAKA_ASPFC
Sequence: MAEFVRAQIFGTTFEITSRYTDLQPVGMGAFGLVCSARDQLTGQPVAVKKIMKPFSTPVLSKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTICSENTLRFVKSLPKRERQPLANKFKNADPEAVDLLERMLVFDPKKRIRAGEALAHEYLSPYHDPTDEPEAEEKFDWSFNDADLPVDTWKIMMYSEILDFHNIDQGNDAGQVLMEGGVAQAQQNYA
What is the function of this protein?
Mitogen-activated protein kinase (MAPK), part of the high-osmolarity glycerol (HOG) pathway (PubMed:26878695).  With mpkC, plays a role in the osmotic and oxidative stress responses (PubMed:26878695).  Involved in paradoxical growth, the cell wall integrity (CWI) pathway and biofilm formation (PubMed:26878695).  SakA and mpkC collaborate during virulence and mpkC could act by modulating sakA activity upon exposure to several types of stresses and during cell wall biosynthesis (PubMed:26878695).
What are the official names of this protein?
Mitogen-activated protein kinase sakA, MAPK sakA.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Translocates to the nucleus upon osmotic stress and cell wall damage.