PharMolix/UniProtQA huggingface dataset:
Protein: LATS2_MOUSE
Sequence: MRPKTFPATTYSGNSRQRLQEIREGLKQPSKASTQGLLVGPNSDTSLDAKVLGSKDASRQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLAPTPVTRRPSFEGTGEALPSYHQLGGANYEGPAALEEMPRQYLDFLFPGAGAGTHGAQAHQHPPKGYSTAVEPSAHFPGTHYGRGHLLSEQPGYGVQRSSSFQNKTPPDAYSSMAKAQGGPPASLTFPAHAGLYTASHHKPAATPPGAHPLHVLGTRGPTFTGESSAQAVLAPSRNSLNADLYELGSTVPWSAAPLARRDSLQKQGLEASRPHVAFRAGPSRTNSFNNPQPEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVAAPTAPATESLETKEGSAGPHPLDVDYGGSERRCPPPPYPKHLLLPSKSEQYSVDLDSLCTSVQQSLRGGTEQDRSDKSHKGAKGDKAGRDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVSRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHMRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWESTLHIPTQVRLSAEARDLITKLCCAADCRLGRDGADDLKAHPFFNTIDFSRDIRKQPAPYVPTISHPMDTSNFDPVDEESPWHEASGESAKAWDTLASPSSKHPEHAFYEFTFRRFFDDNGYPFRCPKPSEPAESADPGDADLEGAAEGCQPVYV
What is the function of this protein?
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability.  Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.  Negative regulator of the androgen receptor.  Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities.  This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase LATS2, Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis (By similarity). Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment (By similarity).
Protein: LIAS_OSTLU
Sequence: MRAVLELTRRRARNARFARARAVVGARARAADAQELRDDSKGGSSVDKATSTAAEARETAHTLEGFREALRHGPGFDDFVRGDVAYSVPAPKSLKDKTTRKPAWLKREVPGGERYTEIKSKLRELKLATVCEEAKCPNLGECWGGGDGKTATATIMIMGDTCTRGCRFCAVKTAKAPPPLDKDEPANVSKAIAAWGLDYVVLTSVDRDDIEDQGAGHFRETVQRLKASCDVLVEALTPDFRGEKHLVELVATSGLDVFAHNVETVPELQRDVRDRRANWDQSIEVLKHAKKSGAKITKTSIMLGLGETHEQVVNALKLLREADVDVVTFGQYMRPTKKHLAVVEYVTPEAFKRYQEIAEEMGFLYVASGAMVRSSYKAGEFFLANVIKQRKAKEAAAAN
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HBE_LEORO
Sequence: MVHFTAEEKAAITSLWGKMNVEEAGGESLGRLLVVYPWTQRFFDNFGNLSSPSAILGNPKVKAHGKKVLTSFGDAIKNMDNLKTTFAKLSELHCDKLHVDPENFRLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAIALGHKYH
What is the function of this protein?
The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.
What are the official names of this protein?
Hemoglobin subunit epsilon, Epsilon-globin, Hemoglobin epsilon chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CRCB_AZOVD
Sequence: MIGVTLAVAVGGALGCLLRFATSNWISAHWPQHFYAATLAVNIAGCLLIGYLYGQFLLRPEVPLALRAGLIAGFLGGLTTFSSFSLDTLRLLESGQAPLAFSYLAFSVLGGLLATWAGLILTKL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y2282_KLEP7
Sequence: MFCVIYRSTKREQTYLYVEKKDDFSRVPDELMRSFGTPQMAMLLPLDGRKKLVNADLEKVKQALSEQGYYLQLPPPSENLLKKHLAEQGKQSD
What are the official names of this protein?
YcgL domain-containing protein KPN78578_22820.
Protein: MUKF_ECOLC
Sequence: MSEFSQTVPELVAWARKNDFSISLPVDRLSFLLAVATLNGERLDGEMSEGELVDAFRHVSDAFEQTSETIGVRANNAINDMVRQRLLNRFTSEQAEGNAIYRLTPLGIGITDYYIRQREFSTLRLSMQLSIVAGELKRAADAAEEGGDEFHWHRNVYAPLKYSVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRAAISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRIICWGQQSIDLWIGYDRHVHKFIRTAIDMDKNRVFAQRLRQSVQTYFDEPWALTYANADRLLDMRDEEMALRDEEVTGELPEDLEYEEFNEIREQLAAIIEEQLAVYKTRQVPLDLGLVVREYLSQYPRARHFDVARIVIDQAVRLGVAQADFTGLPAKWQPINDYGAKVQAHVIDKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: FABA_ECOLU
Sequence: MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTASDLKVGLFQDTSAF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_ECOLU
Sequence: MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAIRGMINAVSFMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: DBHB_VIBCH
Sequence: MNKTQLVEQIAANADISKASAGRALDAFIEAVSGTLQSGDQVALVGFGTFSVRTRAARTGRNPKTGEEIKIAEAKVPSFKAGKALKDACN
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PORB_METBF
Sequence: MSKTAPKTYITSGHSGCAGCCDAFAAKFTLMGAGPNTIVINPTGCLEVMSTPFPYSSWQVPWIHSLFENAGAVASGVEAALKALGKKDDVKVVSIGGDGSTMDIGLGALSGAFERGHDFTYVCMDNEAYMNTGVQRSSGTPFDASTTTTPAGKVSFGNPRPKKNMPAIMAAHGSPYVATTSIGFPRDMIRKVKKATEIVGPTYIHAQAPCPTGWGFDTSKTLEIAKLAVETCLWPMYEMENGEITQVRKVKNPRPVEEYLRAQKRFKHLFTMEGGEEEIKKIQAIADWNIKHFELQ
What are the official names of this protein?
Pyruvate synthase subunit PorB, Pyruvate oxidoreductase beta chain, POR, Pyruvic-ferredoxin oxidoreductase subunit beta.
Protein: AROE_METSB
Sequence: MNAAAPRAFVVGWPIAHSRSPIIHNYWLHQLGLAGRYEAVAVAPPDFADFAQNLAARGFVGGNVTLPHKQNAFGLVAEATHSARRLEAVNTLWIEDGRLYGDNTDSEGFLCALDEAAPGWEAIPGEAVVLGAGGAARAIVAALIDRGRSVVLANRTRARAEAIAAHFGDAPKVIDWRDLPAALKTAGLLVNTTSLGMKGQPPLDLDVALLPQDAVVHDIVYFPLETALLRAARARGLRVAPGLGMLLHQAAPAFARWFATRPKVTPELRRLVEADIEKAL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: PDUL_CITFR
Sequence: MDKQQLETTVTKVLDEMRERPIPLGISNRHIHLCAEDYDRLFPNHPISEKKELLQPGQYAADQTVTLVGPKGQLKNVRLLGPLRSTSQVEISRTDARTLGIAAPLRMSGSIEGTPGVRLISPFAELDLASGVIVAQRHIHMSPLDALILRVSHGDKVSVAINGDERRLIFDNVAVRVSPDMRLEMHIDTDEANAAGADNPQAFATLVSPR
What is the function of this protein?
The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
What are the official names of this protein?
Phosphate propanoyltransferase, Phosphate acyltransferase PduL, Phosphotransacylase PduL, PTAC, Propanediol utilization protein PduL.
What is the protein family that this protein belongs to?
Belongs to the PduL family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: FLBT_RHILW
Sequence: MKSTLRISLKAGERIFINGAVLRVDRKVALEFLNDVTFLLENHVLQPEGATTPLRQLYFIAQMILINPEGKDHSTAMFRKSITMLLSCFKNEEILAELKRIDALVSTGRAFDALKAIRGLYAIEDNILNNHEMPPTMVEQIRREIAPWR
What is the function of this protein?
Has a post-transcriptional repressor function in flagellum biogenesis.  Associates with the 5'-UTR of fljK mRNA and promotes its degradation.
What are the official names of this protein?
Probable flagellum biosynthesis repressor protein FlbT.
What is the protein family that this protein belongs to?
Belongs to the FlbT family.
Protein: LBP_BOVIN
Sequence: MVTSTGTLPSLLLGTLLTFTSGALGANPGLVVRITDQGLEYVAQEELLALQSKLHKVTLPDFNGDVRIKHFGSVDYRFHSLNIQSCKLLGSALKLLPNQGLHFSISDSFIQVTGDWKVRKRILRLDGSFDVKVKGITISVNLLLDSEPSGRPKVAVSSCSSHIRDVEVHISGDLGWLLNLFHNQIESRFRRVLESKICEIIEDSVTSELQPYLQTLPVTTEIDHLAGLDYSLMGAPQATAQMLDVMFKGEIFSRDDRFPVAFLAPVMNLPEEHSRMVYFAISDYAFNTASLVYHKAGFLNFTITDDVIPPDSSIRQNTKSFRAFVPRIARLYPNTNLELQGAVISAPCLNFSPGNLSTAAQMEIEAFVLLPNSVKEPVFRLSVATNVSAMLTFNTSKITGFLEPGKIQVELKESKVGRFNVELLEALLNYYLLNNFYPKVNDKLAEGFPLPLLRKIQLYDPILQIHKDFLFLGTNVRYLRV
What is the function of this protein?
Plays a role in the innate immune response.  Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria.  Acts as an affinity enhancer for CD14, facilitating its association with LPS.  Promotes the release of cytokines in response to bacterial lipopolysaccharide.
What are the official names of this protein?
Lipopolysaccharide-binding protein, LBP.
What is the protein family that this protein belongs to?
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Protein: RL34_PSEFS
Sequence: MKRTFQPSTIKRARTHGFRARMATKNGRAVLSRRRAKGRARLAV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RS19_SHESM
Sequence: MPRSLKKGPFIDLHLLKKVEKAMEAGDKKPIKTWSRRSMIIPNMIGLTIAVHNGRQHVPVFVTDEMIGHKLGEFSPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: UREE_RHILV
Sequence: MQRVTSYLPAGTPSSHPIAQVKLPHDLRHLRRKLLHLENGEMVMLDLKDPVLFANGDLLVRDDGELIEILAADEKLFEIRGRDRTHLVELAWHLGNRHLAAQIEEDRIVILRDHVIRTMLQGLGAVVLEIDEPFQPARGAYHSQGGHSHGHDHDHNHDHGDDHGHDHSHSHDHDHEHGYEHEHEHRHDRGHDHDHKHD
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_MYCA9
Sequence: MSSLREEIRSALDVSPTIDPAAEVSRRVGFLKDYLRASSTKGFVLGISGGQDSALAGRLCQLAAQESRLEGVAAEFIAVRLPYGVQADEEDAQVALRFIDPDRTIVINIKETSDAATKAVAEALGETPTDFVRGNIKARERMVVQYAAAGQHRLLVVGTDHAAEAVTGFFTKFGDGGVDVTPLTGLTKRQGAQILSHLGAPDSISHKVPTADLEDDRPALPDEVALGVTYAQIDDYLEGKAVTVEAADRIERWYLQTRHKRAQPVTPFDGWWR
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: RH56_ORYSJ
Sequence: MAEAEVKDNEVYEEDLVDYEEEVENGTDGGANAANASADVVKKGYVGIHSSGFRDFLLKPELLRAIQDCGFEHPSEVQHECIPQAILGMDVICQAKSGMGKTAVFVLSSLQQIDPVAGQVGALVLCHTRELAYQICHEFERFSKYLPEVKVAVFYGGVHIKKHKDLLKNDCPHIVVGTPGRILALAREKDLSLKNVRHFILDECDKMLDSLDMRRDVQEIFKMTPHDKQVMMFSATLSKEIRPVCKKFMQDPMEIYVDDEAKLTLHGLVQHYIKLSEAEKNRKLNDLLDALDFNQVVIFVKSVSRAAELNKLLCECNFPAISIHSGMTQEERLTRYKNFKEGHKRILVATDLVGRGIDIERVNIVINYDMPDSADSYLHRVGRAGRFGTKGLAITFVSSASDSDVLNQVQERFEVDIKELPEQIDTSTYMPS
What is the function of this protein?
ATP-binding RNA helicase involved in pre-mRNA splicing.  Required for the export of mRNA out of the nucleus (By similarity).  Required for tapetal programmed cell death (PCD) and degeneration during anther development.  Forms dimer with AIP2 and binds the promoter region of the cysteine protease CP1.  Can complement the yeast RNA helicase SUB2.  Plants silencing AIP1 and AIP2 are male sterile (PubMed:21467577).
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 56, API5-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL32_GLOVI
Sequence: MAQPKKKTSNAKRDQRRATWKRKARVQAEKALALGKSILSGNNTGFYYPQLEAEEEEQAEE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: BIOF_BURVG
Sequence: MKPGAPPIATPLLDTLQRGLAELDAQGLRRVRRTADTACDAHMRVDGRDIVGFASNDYLGLAAHPALVAAFAEGAQRYGSGSGGSHLLGGHSRAHARLEDELAGFAGGFSDAPRALYFSTGYMANLAAMTALTGKQATIFSDALNHASLIDGIRLSRANVQIYPHADMHALGALLDASDAPTKLIVSDTVFSMDGDLAPLAELVALAERHGAWLVVDDAHGFGVLGPQGRGALAAAALRSPNLVYVGTLGKAAGVAGAFVVAHETAIEWMIQRARSYIFTTAAPPAVAHAVSASLKVIGGDEGDARRAHLAALIERTRALLRATRWQPVDSHTAVQPLVIGSNDATLAAMRALDARGLWVPAIRPPTVPAGTSRLRISLSAAHSFDDLARLEAALIAASEASA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: UBA5_CAEEL
Sequence: MSDEQIDKLVSRLDGALNRLGNVKKDHPLESSSNSKPTHQPKSPAPYRQKIEKLSAEVVDSNPYSRLMALQRMGIVNEYERIREKTVAVVGVGGVGSVVAEMLTRCGIGKLILFDYDKVEIANMNRLFYQPNQAGLSKVEAARDTLIHVNPDVQIEVHNFNITTMDNFDTFVNRIRKGSLTDGKIDLVLSCVDNFEARMAVNMACNEENQIWMESGVSENAVSGHIQYIEPGKTACFACVPPLVVASGIDERTLKRDGVCAASLPTTMAVVAGFLVMNTLKYLLNFGEVSQYVGYNALSDFFPRDSIKPNPYCDDSHCLQRQKEYEEKVANQPVDLEVEVPEEETVVHEDNEWGIELVNESEPSAEQSSSLNAGTGLKFAYEPIKRDAQTELSPAQAATHDFMKSIKDKLVEEAQNKGK
What is the function of this protein?
E1-like enzyme which activates ufm-1.  Required for interaction between ufm-1 and ufc-1.
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme 5, Ubiquitin-activating enzyme 5.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
Protein: DCUP_SYNJB
Sequence: MGDRLLRAARGEVLDRPPVWMMRQAGRYMAAYRELQSKYTFKQRCEIPELAVEISLQPFRAFAPDGVILFSDILTPLEGMGIPFELVEHQGPIIDPPIRSQAQIERIRLLEPEESLPFIKTILSTLRREVEGKATLLGFVGSPWTLACYAVEGRSSKDYAHIKSLAFAQPPLLHQLLSKLADSIARYVIYQIEGGAQVVQLFDTWAGQLSPVDYECWALPYQKQIVDQVKARYPQVPLILYINGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNLDPMVLLGSPEFIRQRTLEVIRKAGSRGHIMNLGHGIHPSTPEANVHYFFETVRQSAELIHLR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_SHIDS
Sequence: MLNKLSLLLKDAGIPLTDHQKNQLIAYVNMLHKWNKAYNLTSVRDPNEMLVRHILDSIVVAPYLQGERFIDVGTGPGLPGIPLSIVRPEAHFTLLDSLGKRVRFLRQVQHELKLENIEPVQSRVEEFPSEPPFDGVISRAFASLNDMVSWCHHLPGEQGRFYALKGQMPEDEIALLHEEYQVESVVKLQVPALDGERHLVVIKANKI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL132_HCMVA
Sequence: MPAPRGLLRATFLVLVAFGLLLHIDFSDATNMTSSTNVPTSTSSRNTVESTTSSEPTTETNMTTARESSVHDARNDEIMKVLAILFYIVTGTSIFSFIAVLIAVVYSSCCKHPGRFRFADEEAVNLLDDTDDSGGSSPFGSGSRRGSQIPAGFCSSSPYQRLETRDWDEEEEASAARERMKHDPENVIYFRKDGNLDTSFVNPNYGRGSPLTIESHLSDNEEDPIRYYVSVYDELTASEMEEPSNSTSWQIPKLMKVAMQPVSLRDPEYD
What are the official names of this protein?
Envelope glycoprotein UL132, L3.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 UL132 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein.
Protein: ILVC_PROM2
Sequence: MTQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAVSDGLQVFSVSEACEKADWIMILLPDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPPSFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGSARSLAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMVKGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKNKPLMTKLREENSKHEIEKVGKGLRSMFSWLK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ATP6_LISIN
Sequence: MEEEFPTISLLGIDFNLSNILMITVTCVIVLLIAIICTRNLQRRPTGKQNFIEWVMDFVRGIINSNMDWKTGGRFHVLGITLLMFIFVANMLGLPFQIAINDEVWWRSPTADPIVTLTLAIMVLGLTHYYGIKMRGFKHYFVGTYFSPMKFLFPLKLVEEFANTLTLGLRLYGNIFAGEVLLTIIATQLAHMNIFVGVLAIIPALLWQGFSIFIGAIQAYIFTMLTMVYMSHKVSDEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UBIE_BURVG
Sequence: MSKTHFGFESVEETEKAKKVAGVFHSVASNYDLMNDLMSAGMHRAWKAFTIAQANVRPGFKVLDIAAGTGDLTRAFAKAAGPTGEVWHTDINESMLRVGRDRLLDKGVVTPSLLCDAEKLPFPNNYFDVVTVAFGLRNMTHKDAALAEMRRVAKPGGRVMVLEFSKVWEPLKKAYDLYSFKVLPWLGDRFAKDADSYRYLAESIRMHPDQDTLKTMMEQAGLDAVKYYNLSGGVVALHVGSKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: DBHA_SHIFL
Sequence: MNKTQLIDVIAEKAELSKTQAKAALESTLAAITESLKEGDAVQLVGFGTFKVNHRAERTGRNPQTGKEIKIAAANVPAFVSGKALKDAVK
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU-alpha, HU-2, NS2.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: ARSC1_CORGK
Sequence: MNNQPSVLFVCVGNGGKSQMAAALAKKHAGDALKVYSAGTKPGTKLNQQSLDSIAEVGADMSQGFPKGIDQELIKRVDRVVILGAEAQLEMPIDANGILQRWVTDEPSERGIEGMERMRLVRDDIDARVQNLVAELTQNA
What is the function of this protein?
Involved in defense against toxic arsenate.  Involved in the mycothiol/myoredoxin redox pathway which uses a mycothioltransferase mechanism; facilitates adduct formation between arsenate and mycothiol (By similarity).
What are the official names of this protein?
Arsenate-mycothiol transferase ArsC1, Mycothiol-dependent arsenate reductase ArsC1.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm.