PharMolix/UniProtQA huggingface dataset:
Protein: COX2_DROAI
Sequence: MSTWANLGLQDSASPLMEQLIFFHDHALLILVMITVLVGYLMFMLFFNSYVNRFLLHGQLIEMIWTILPAIILLFIAMPSLRLLYLLDEINEPSITLKSIGHQWYWSYEYSDFNNVEFDSYMIPTNELANDGFRLLDVDNRIVLPMNSQIRILVTAADVIHSWTVPALGVKVDGTPGRLNQTNFFINRPGLFYGQCSEICGANHSFMPIVIESVPVNYFIKWISNSVNS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS20_COXBU
Sequence: MANSAQAKKRARQNEKRELHNASQRSAVRTAVKKILKSLQANDSSAAQSAYQHAVQILDKAAGRRIIHPNKAARLKSRLSQKIKNLSSSQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: DGLA_HUMAN
Sequence: MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFALAAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRNSSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIRTSTPTGHGASPAKQDELVISAR
What is the function of this protein?
Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535).  Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:26668358, PubMed:23502535).  Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053).  Plays a key role in regulating 2-AG signaling in the central nervous system (CNS).  Regulates 2-AG involved in retrograde suppression at central synapses.  Supports axonal growth during development and adult neurogenesis.  Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors.  Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity).
What are the official names of this protein?
Diacylglycerol lipase-alpha, DAGL-alpha, DGL-alpha, Neural stem cell-derived dendrite regulator, Sn1-specific diacylglycerol lipase alpha.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
Protein: CAN_EMENI
Sequence: MPDPSDRKAVTRYLEQTHDKIFESNRAWVASKKGADPEFFNKLAAGQSPEYLYIGCSDSRVPANEIMGLDAGEVFVHRNIANVVPTIDLSSMSVINYAVGHLKVKHIVVCGHYNCGGVQAALTPTDLGILNPWLRNIRDVYRLHEKELDAIEDDGERFNRLVELNVIESCRSVIKTAVVQQSYEENGFPIVHGWVFNLKDGLLKDLNIDFPGILADIQKIYNLTKGSS
What is the function of this protein?
Catalyzes the reversible hydration of CO(2) to H(2)CO(3).  The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase (By similarity).  Involved in osmoadaptation.
What are the official names of this protein?
Carbonic anhydrase, Carbonate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the beta-class carbonic anhydrase family.
Protein: ATP62_CHLL3
Sequence: MKRVKVIQIKGFFRVMALLAPLLLNAYLPVQASEEHAAPVAAVVAAHAEAAVDPALEPAHAEPAGHEDEKAGDVIMHHILNSHSFSFEPFGTIHLPTLPPVFGIDISITKHVVMLWIVSAILLVLFSFVGAAYRKITPKTAPSGVANTMEALVEFIRLDVAKSNIGHGYEAHLPYLLTVFMFILLCNILGLIPYGATATGNINVTLTLAVFTFFITQAASLKAHGLKGYLTHLTAGTHWSLWIIMIPIEVIGLFTKPFALTVRLFANMTAGHIVILSLIFISFILKSYVVAAAVSVPFSIFIYLLEIFVAFLQAFIFTMLSALFIGLATAHEGGEAEAAHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a 2, ATP synthase F0 sector subunit a 2, F-ATPase subunit 6 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PA1A_LITPA
Sequence: ALFSILRGLKKLGKMGQAFVNCEIYKKC
What is the function of this protein?
Antimicrobial activity against Gram-negative bacterium E. coli.
What are the official names of this protein?
Palustrin-1a.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MTLD_CALS4
Sequence: MLKALHFGAGNIGRGFIGYLLNKSGYEVTFVDISKEIVDNINKYKKYNVIILKEPVEKEEVKEVKALHLEEEDKVLDAFLEADMVTTSVGVSNLSSIGGRLKKYLKARKEKNEKPLDIMACENALFATDVLRERVVKEEDDDFITYLNLKVGFPNTAVDRIVPAVKIDKKLPVDVAVEEFFEWDIEKNKIKGNLQIEGVELVDDLKPYIERKLFLLNGAHATTAYLGYLRGYTYIHQAIKDDNIRAIVKGMQEEISTALSKKYDVDKESLMAYAEKVIKRFENPYLQDEVTRVGREPLRKLSSEDRLIAPLKLCSEVGITPNFILYGIAAGLLFDYKEDAQAVKMREYVEQFGIKKAVNVITGLEEESDLVEEIEKRYFELKGKLI
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: H2B3B_MOUSE
Sequence: MPDPSKSAPAPKKGSKKAVTKAQKKDGKKRKRGRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B type 3-B, H2B-clustered histone 26, H2B.U histone 1.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: YBEY_CUTAK
Sequence: MIDITNESGSPSNEEGLVGLATFALDRLRIHPSSELSIILVDEETMEAYHEKFMGLPGPTDVLSFPMDEMRAPGDDEDPPSGLLGDIVLCPTVTARQAAENGRTPDGEAEYLLIHGLLHLLGHDHAEPGEKRVMFRLNDEIIAAWDDHREQTGQR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2784_CITK8
Sequence: MTIWVDADACPNVIKEILYRASERMQMPLILVANQNLRVPPSRFIRTLRVPAGFDVADNEIVRQCEAGDLVITADIPLASEVLEKGAAALNPRGERYTESTIRERLTMRDFMDTLRASGIQTGGPDSLSPRDRQHFAAELDKWWLEVQRRTR
What are the official names of this protein?
UPF0178 protein CKO_02784.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: YMC2_YEAST
Sequence: MSEEFPTPQLLDELEDQQKVTTPNEKRELSSNRVLKDIFAGTIGGIAQVLVGQPFDTTKVRLQTATTRTTTLEVLRNLVKNEGVFAFYKGALTPLLGVGICVSVQFGVNEAMKRFFQNYNASKNPNMSSQDVDLSRSNTLPLSQYYVCGLTGGVVNSFLASPIEQIRIRLQTQTSNGGDREFKGPWDCIKKLKAQGGLMRGLFPTMIRAGHGLGTYFLVYEALVAREIGTGLTRNEIPPWKLCLFGAFSGTMLWLTVYPLDVVKSIIQNDDLRKPKYKNSISYVAKTIYAKEGIRAFFKGFGPTMVRSAPVNGATFLTFELVMRFLGEE
What are the official names of this protein?
Carrier protein YMC2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NRAM_I01A0
Sequence: MNPNQKIITIGSICMVIGIVSLMLQIGNIISIWVSHSIQTGNQHQAEPIGNTNFLTEKAVASVTLAGNSSLCPISGWAVHSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPDAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSPNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTGTDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: DAPB_BURMS
Sequence: MSSMKIAIAGASGRMGRMLIEAVLAAPDATLAGALDRTGSSQLGQDAGAFLGKQTGVALTDDIERVCAEADYLIDFTRPEGTLAHLDAALRHDVKLVIGTTGFSEPQKAQLRAAGGKIALVFSANMSVGVNVTMKLLEFAAKQFAQGYDIEIIEAHHRHKVDAPSGTALMMGETIAAATGRTLDDCAVYGRHGVTGERDPSTIGFSAIRGGDIVGDHTVLFAGIGERIEITHKSASRVSYAQGALRAARFLAGHQAGFFDMQDVLGLR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFT57_MOUSE
Sequence: MAAAAAVIPPSGLDDGVSRARGEGAGEAVVERGPGAAYHMFVVMEDLVEKLKLLRYEEELLRKSNLKPPSRHYFALPTNPGEQFYMFCTLAAWLINKTGRAFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEQVCYVLDCLAEEALKYIGFTWKRPSYPVEELEEETVPEDDAELTLSKVDEEFVEEETDNEENFIDLNVLKAQTYRLDTNESAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHKSGIESALKETKGFLDKLHNEISRTLEKIGSREKYINNQLEHLVQEYRGAQAQLSEARERYQQGNGGVTERTRLLSEVTEELEKVKQEMEEKGSSMTDGTPLVKIKQSLTKLKQETVQMDIRIGVVEHTLLQSKLKEKCNMTRDMHAAVTPESAIGFY
What is the function of this protein?
Required for the formation of cilia.  Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway.  Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis.  Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
What are the official names of this protein?
Intraflagellar transport protein 57 homolog, HIP1-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the IFT57 family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Note=Concentrates within the inner segment of cilia.
Protein: RS12_THET8
Sequence: MPTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGVYDAAGVKDRKKSRSKYGTKKPKEAAKTAAKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone (PubMed:11014182, PubMed:11007480, PubMed:11163189, PubMed:11014183, PubMed:11511350, PubMed:11296217, PubMed:11228145, PubMed:11228145, PubMed:11283358, PubMed:11340196, PubMed:11866529).  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (PubMed:11283358).
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: NT5D3_HUMAN
Sequence: MTMAAAAVVARGAGARAATAAALRGGCGTAARGRPCAGPARPLCTAPGTAPDMKRYLWERYREAKRSTEELVPSIMSNLLNPDAIFSNNEMSLSDIEIYGFDYDYTLVFYSKHLHTLIFNAARDLLINEHRYPAEIRKYEYDPNFAIRGLHYDVQRAVLMKIDAFHYIQLGTVYRGLSVVPDEEVIEMYEGSHVPLEQMSDFYGKSSHGNTMKQFMDIFSLPEMTLLSCVNEYFLKNNIDYEPVHLYKDVKDSIRDVHIKGIMYRAIEADIEKYICYAEQTRAVLAKLADHGKKMFLITNSPSSFVDKGMSYIVGKDWRDLFDVVIVQAEKPNFFNDKRRPFRKMNEKGVLLWDKIHKLQKGQIYKQGNLYEFLKLTGWRGSRVLYFGDHIYSDLADLTLKHGWRTGAIIPELRSELKIMNTEQYIQTMTWLQTLTGLLEQMQVHRDAESQLVLQEWKKERKEMREMTKSFFNAQFGSLFRTDQNPTYFLRRLSRFADIYMASLSCLLNYDVSHTFYPRRTPLQHELPAWSERPPTFGTPLLQEAQAK
What are the official names of this protein?
5'-nucleotidase domain-containing protein 3, GRP94-neighboring nucleotidase.
What is the protein family that this protein belongs to?
Belongs to the 5'(3')-deoxyribonucleotidase family.
Protein: PED1B_BOVIN
Sequence: MVHLLASEVRQLLHNKFVVILGDSVQRAVYKDLVLLLQKDCLLTLSQLKAKGEHTFEQDELVHGGQQGHMHNGTHYREVRQFCSGQHLVRFYFLTRVYSDYLEDVLEELQSGEHHPDLVIMNSCLWDITRYGKDFWPSYRRNLERLFGRLRQMLSESCLLVWNTAMPVGDKITSRFVPPEVQFTSSSVKISVIEANFYSSAEAQKHGFDVLDLHFHFRRHTGKYLQTDGVHWNQCAHRHLSQLLLAHVADAWGVELPRRDPVDKWIPDGPGRRRPGRRLERQPLVCGDQPACPLPRPLPLPGRQPLLPTPPCPPLFPLLSPQRHPIPLHQVMPPFPFCPQETCFSSDHPFQSDQFSLNYLHSDVPPSIQTEFAVQGDFQYGPQPPMPRFPPPCYQQRVPEVHRGFPRYHPPDPYMPWRRRPKTSKRRASAYKEPRPQ
What are the official names of this protein?
PC-esterase domain-containing protein 1B, Protein FAM113B.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family.
Protein: ALKR1_ARATH
Sequence: MAAASGVRRIKLGSQGLEVSAQGLGCMGLSIFDGTTKVETDLIALIHHAINSGITLLDTSDIYGPETNELLLGQALKDGMREKVELATKFGLLLKDQKLGYRGDPAYVRAACEASLRRLGVSCIDLYYQHRIDTTVPIEVTIGELKKLVEEGKIKYIGLSEACASTIRRAHAVHPLTAVQLEWSLWSRDVEEDIIPTCRELGIGIVAYSPLGLGFFAAGPKFIESMDNGDYRKGLPRFQQENLDHNKILYEKVNAMAEKKSCTPAQLALAWVHHQGNDVCPIPGTSKIKNLNQNIGALSVKLSIEEMAELDAMGHPDSVKGERSATYIVTYKNSETPPLSSWTS
What are the official names of this protein?
Probable aldo-keto reductase 1.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: HBB_PHACO
Sequence: VHWSAEEKQLITGLWGKVNVADCGAEALARLLIVYPWTQRFFASFGNLSSPTAILGNPMVRAHGKKVLTSFGDAVKNLDNIKNTFSQLSELHCDKLHVDPENFRLLGDILIIVLAAHFSKDFTPECQAAWQKLVRVVAHALARKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: YAJ3_YEAST
Sequence: MINFLLFVLTILATLTNIWFSGVLSPAMVIRICLGGSMVVLQIWSFSRPISNETFRTKLLLEVITHRPSIAGKEWKTITYNMNQYLFKAGLWKTPYHFFCEHQCYEFFKDLIKGKYPDVQWDTANTQPFISVPENQAATQNSDVEPTVKWCLFKAAEIQAHAVREYWQSQYPDVGIPAI
What are the official names of this protein?
Putative DUP240 protein YAR023C.
What is the protein family that this protein belongs to?
Belongs to the DUP/COS family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PGDH_HUMAN
Sequence: MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
What is the function of this protein?
Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:8086429, PubMed:10837478, PubMed:16828555, PubMed:16757471, PubMed:21916491, PubMed:25586183).  Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:25586183, PubMed:15574495).  Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation.  Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (PubMed:16757471, PubMed:22844113).
What are the official names of this protein?
15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-PGDH, Eicosanoid/docosanoid dehydrogenase [NAD(+)], Prostaglandin dehydrogenase 1, Short chain dehydrogenase/reductase family 36C member 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYTC_ARATH
Sequence: MANNHHPKDEAYLSSVIPKRIRLFEEIQAEQLEQLQSRPHDPIKITLLPDGIEKEGRRWETSPMDIAVQISKGLAKSALVSSVNHVLWDMNRPLEGDCSLEIFGFDSDQGRNTFWHSSAHILGQALEQEYGCKLCIGPCEPRDEGFYYDSLYYGELGLNDNHFPNIEAKLPIRMAEFGVLHRNEDSGALGGMTRVRRFVQDDAHIFCRVDQVEEEVKGVLDFIDYVYRIFGFTYELTLSTRPKDHIGDLETWAKAENDLEKALDDFGKPWVIKEGDGAFYGPKIDITVSDARNRKFQCATIQLDFQLPACFKLKYLSEKNEMEAPVMIHSAVLGSIERMFAILLEHYKGIWPFWLSPRQAIVCSLSEDCSSYAKQVQKQINEVGYYVDIDESDRSLRKKVADARDAPYNYILVVGQKEVATGQVTVRLREDPEGRKDLPEMSIESLLDEFKFKTVNFL
What are the official names of this protein?
Probable threonine--tRNA ligase, cytoplasmic, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_COPPD
Sequence: MSVNDSTHIKTRFAPSPTGYLHVGGARTALFNYLFAKKFGGTFLLRIEDTDPERSKPEYSEQILISMKWLGLDWDEGPYHQSERMHIYQQYTQKLLEEGKAYRCFCTTEELEQMREQQRQQGLPTRYDGRCSRLTQEEIEERLNKGMPFAVRLKVPQDRGIIAWDDMVKGHIEINSSELDDFILVRSDGTPTYNFAVVIDDHTMGVTHVLRGEDHIPNTPKQILIYEALGWETPEFGHVPMILGKDKTKLSKRHGAVGVEAYRDEGFLPEALFNFLALLGASYDPDREVYTKQELIDLFDPKKIGLHPAVFDPDKLYYINREHMKMLPPEELLDRIRPFAEAKGFQIEPYHLRLIPLLVERMRTLKDFVELADYIFTDDFTVDEKAQELLAKDLPLGGLAEQLDATVWDADHIEAVLRQYAQDKGIKPRDYFPFIRAVISGKSVGPSLFHLMEAMPKDMVLRRLRKS
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAA_STAAS
Sequence: MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.