PharMolix/UniProtQA huggingface dataset:
Protein: GTR1_DROME
Sequence: MAFLCAPGLTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSESHISTMELICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFRHNNGRSMLNCTNSLEPQSMNSGIEHAALMVSEEKTQHDSLFGTTSFSLTVEGMGPYPLSDSTNLLGPGSSSYGPGGVLGLAGSGSGLGGQCYTNYGTNLQTPQAARKCHYDEVDDYSFRRHSAHGRITQMKGKPLILGPTIKKDKKKERTDWLTASERFLEGGRSTHQGRSAASAPHHPRQPPPVCPSSGPXLRSASPPDSASVRSTSRAEEPHQPQQVHHQQQQVHHQQQHQSRYATHEYVHCSYEKEVVCDQANPSQAPPQQPAPPVQQHQQQPPPPLHHCQQRKHSHSPHHSRHTSPHSHHHHSHHSRHSRRSRRQGSGSLPGAHQGSANHSVMRPSICTSRRHRSVTDISTTNVCQDPACSDREVQEIMVRRTCCNTTATNSSSRTELAQCFAEDLYGSSRRPSSCCTSSDYCYQTDSTSLYGSRSSLSRNNSIKSASALVRKHHRSQRSLLPEHRHPSYTSISLRGLNASRPNSQLGSLTSIFDRAKNMAPEGSTLERQSSKGALGSSELPEYACSPSPIRWSFLADGRSPSEMEGAVGGGPEREQEEEDKLDAWQVPEPEPEKKPCRKITTSSSVYDEGPSTSAAAARKRRGSKGSRGSKGSGSYHCEFEDEATTTVMFHQDAGEAYNNCCSNNYNYIQCNTYLDQDLQITSEDIHQYLSKGDATASDILNNSKNYPFQPSNALEFQYKNNFQQGQANANNNNTNTTNTASSDAAECFQNYRAISKETNLNQTSTEQLSPTNINLSTSSNNINIVFSSSLERNANEVKFINNRSGASGGSEMGCEVGHHAGYLPYTYPSYDYTNMSGNSHFEKPLGIDELPKEFCGLEGAGGGGASTTSEHSSSLPSPQPLTHHQQLHHFESFDAASEHNLLAAQPMSPGSPLSGSVNPAGDDFVQMHHYHHANSPHSQSHHSHAHTHTHGHHVHHLLNHPAYDLTDDQFRLGSALKRVRKRARKYTDFLRKK
What is the function of this protein?
Facilitative glucose transporter.
What are the official names of this protein?
Glucose transporter type 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YCX3_EUGLO
Sequence: MNSSVFIRNARYRCYNYILNFIKFRQSNKPKKISKYKKGKEIKPFDSNNKFHKNRRYWINKQVAIRKMEKEMMLYLLKNKEPLSKEKKIRMKKIRLILKKLIYKKVKTKRQKFKFFKKNKLALNFKRKRYVNVLGRIVPKRFTKLKSKEQAFYFEIYVIY
What are the official names of this protein?
Uncharacterized 20.0 kDa protein in rps12-trnP intergenic region, ORF160.
What are the subcellular locations of this protein?
Plastid.
Protein: IL10_BUBCA
Sequence: MPSSSALLCCLVFLAGVAASRDASTLSDSSCTQFPTSLPHMLRELRAAFSRVKTFFQMKDQLDSLLLTQSLLDDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEQVKRAFSKLQDRGVYKAMSEFDIFINYIETYVTTKMQK
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYW_ARCFU
Sequence: MNVTPWEVEGVIDYSKLIEEFGMQPFSEVLPEIDNPHILMRRGAIFGHRDYWRIIEAMQKKEPWAVMSGFMPSGLPHFGHKMTMDEIVWHQSAGGKAFVAIADMEAHSVRGLSWEKTRELGMLYIKSIIALGLREDAVIYFQSKSSHVKDLAFELSAEVNFSELRAIYGFNSDTSLAKMFVTAIQAADILHPQLSDFGGPKPVVVPVGADQDPHMRLTRDLAARISIFSFEPVEGGVRVRSRKGAEYLSSLRDLEFDKKIYEEHMDIFGEAEEIERAVRKIEVEIGGFAFIPPSSTYHRFTTGLTGGKMSSSKPESYISLLDPPEEGAKKVMKAFTGGRATAEEQRRLGGEPDRCVVFELYSFHLIDSDEELNQIEAECREGRLLCGKCKKMAAELVKSFLKEHQEKMEAVDLSNYTIIG
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2C_GALSU
Sequence: MNKINNNLEFNGNEDEHFIEYYNNKNYKSDLLKANKNNKTKNKKNSNFNFKSIEKNRLNYNNKKNKFILNRKAYYNSNENINCQSDIIYVEENITVNELASKIGVEATEILKVLFKKGKLLNINQILDLSLLNLISQELKINITTIDKKNNIYINTESNNDQNINDKHVKLRAPIVAVLGHVNHGKTSLIEKLIKNDLTKAETGHITQHIGAYEFIIGPKDKKIILLDTPGHEAFESIRQRVLKISDIILLIIAADEGI
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LPP19_BOMMO
Sequence: MKPAIVILCLFVASLYAADSDVPNDILEEQLYNSVVVADYDSAVEKSKHLYEEKKSEVITNVVNKLIRNNKMNCMEYAYQLWLQGSKDIVRDCFPVEFRLIFAENAIKLMYKRDGLALTLSNDVQGDDGRPAYGKDKTSPRVSWKLIALWENNKVYFKILNTERNQYLVLGVGTNWNGDHMAFGVNSVDSFRAQWYLQPAKYDNDVLFYIYNREYSKALTLSRTVEPSGHRMAWGYNGRVIGSPEHYAWGIKAF
What are the official names of this protein?
Low molecular mass lipoprotein PBMHPC-19.
What is the protein family that this protein belongs to?
Belongs to the 30 kDa lipoprotein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL34_SHEPW
Sequence: MSKRTFQPSNLKRKRSHGFRARMATVGGRKVIARRRAKGRARLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RBFA_POLNA
Sequence: MRKKSSTPNRGFRVADQIQRDLTELIARELKDPRVGMVTVQSVEVTPDYAHAKIYFSVLVGDPKECEIALNQAAGFLRNGLFKRLMTHTVPTLHFHFDQTTERAADLNALIAKAVSSRAQDD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_VIBCH
Sequence: MTTLTLAELATITGGELFGDPTALVSAVAPMDKAQLGHVTFLSNPKYSKHLGDCKATVIMVKTSERELCPSNALVVADPYVAFAKVAQALDSTPSPAHGIAPSAVIAEDAKLGHNVSIGANAVIESGVQLGDNVVIGAGCFIGKQARLGDNTKLWANVTIYHKVEIGSDCLIQSGTVIGADGFGYANERGEWIKIPQLGSVRIGDRVEIGACTTIDRGALDDTVIEDNVIIDNQLQIAHNVHIGYGSALAGGTVIAGSTRIGKYCIIGGASVINGHIEIADGVTITGMGMVMRSIEEKGMYSSGIPLQTNKEWRKTAARVHRIDDMHKRLKALEKLLEQSDTVQPDNSQAE
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: ZN335_RAT
Sequence: MEENEVESSSDAAPRPGQPEEPSESGLGVGTSEAVSADSTDAATAPGLTEADDSGVGQSSDSGSRSVEEVSESISTEPLPQGYLPDSSSVSRGPVAEVPGGPPALVHSSALPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSTCLEPAEQPPGEPSSLAQPPAPVVEELDLQGLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAVAAAAAGKRGRVRKWGTSTKTTEEEGPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTLRPRRRPGRPRKLPRLETSDLHDGIGEPLVSSQSTQSPPELQDLEAPSSSDLRALGKVGRGLVETGVSQSDAENAAPSCQDEADVPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAPGPPLSSAGPEAPQEPAPFQPPETPPLLCPDALGGATIIYQQGAEESTAMATQTALDLLLNMSAQRELGATALQVAVVKSEDVEAELTSTARQPSSEDTTPRVVTLHVAESGSSVAAESQLGPSDLQQIALPPGPFSGASYSVITAPPVEGRASASGPPYREEPPGEAAQAVVVNDTLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGPEVLSPTKTHHTGGSQGSSTPPPATSHALGLLVPHSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRAHAGPAAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNGHLKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHTAFQSNHGTLGTERLQQALSQEHIIVAQEQTVANQEEATYIQEITADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPDGHHIQVQEGQITHIQYEQGTPFLQESQIQYVPVSPSQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEHIQQLQHQGIEYDVITLSDD
What is the function of this protein?
Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (By similarity).  Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity).  Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (By similarity).  Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (By similarity).
What are the official names of this protein?
Zinc finger protein 335, NRC-interacting factor 1, NIF-1.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYY_PYRFU
Sequence: MDIEERIKLVLKKPTEEVLTVENLRHLFEIGAPLQHYIGFEISGYIHLGTGLMAGAKIADFQKAGIKTRVFLADWHSWINDKLGGDLETIQEVALKYFKVGMEKSIEVMGGKPEKVEFVLASEILEKGDYWQTVIDISKNVTLSRVLRSITIMGRKMGEAIDFAKLIYPMMQVADIFYQGVTIAHAGMDQRKAHVIAIEVAEKLRYHPIIHNGEKLKPVAVHHHLLLGLQEPPKWPIESEEEFKEIKAEMKMSKSKPYSAVFIHDSPEEIREKLRKAFCPAREVKYNPVLDWVEYLVFREEPTEFTIHRPAKYGGDVTYTTFEELKRDFAEGKLHPLDLKNAVAEYLIDLLEPIRKYFERHPEPLELMKSVQITR
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUCL1_HUMAN
Sequence: MKFLAVLVLLGVSIFLVSAQNPTTAAPADTYPATGPADDEAPDAETTAAATTATTAAPTTATTAASTTARKDIPVLPKWVGDLPNGRVCP
What is the function of this protein?
May play a role as marker for the diagnosis of metastatic breast cancer.
What are the official names of this protein?
Mucin-like protein 1, Protein BS106, Small breast epithelial mucin.
What are the subcellular locations of this protein?
Secreted. Membrane.
Protein: BETA_SINFN
Sequence: MQADYIIIGSGSAGSALAHRLSEDSRNSVIVLEFGGTDIGPFIQMPAALAWPMSMNRYNWGYLSEPEPHLNNRRITAPRGKVIGGSSSINGMVYVRGHAEDFDRWEQLGAKGWAYADVLPYFKRMEHSHGGEDGWRGTDGPLHVQRGPVKNPLFHAFVEAGKQAGFEMTDDYNGSKQEGFGLMEQTTWRGRRWSAASAYLKPALKRPNVQLIRCFARKIVIENGRATGVEIERGGRIEVVKANREVIVSASSFNSPKLLMLSGIGPAAHLKDLGIDVKVDRPGVGQNLQDHMEFYFQQISTKPVSLYSWLPWFWQGVAGAQWLFFKSGLGISNQFEACAFLRSAPGVKQPDIQYHFLPVAIRYDGKAAANTHGFQVHVGYNLSKSRGSVTLRASDPKADPVIRFNYMSHPEDWEKFRHCVRLTREIFGQKAFDQYRGPEIQPGERVQTDEEIDAFLREHLESAYHPCGTCKMGSKDDPMAVVDPETRVIGVDGLRVADSSIFPHVTYGNLNAPSIMTGEKAADHILGKQPLARSNQEPWINPRWAISDR
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: KDSC_SALTY
Sequence: MSKAGASLATCYGPVSPHVMTKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSNIEVAIITGRKAKLVEDRCATLGIVHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTHIAGGRGAVREVCDLLLLAQGKLDEAKGQSI
What is the function of this protein?
Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
What are the official names of this protein?
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC, KDO 8-P phosphatase.
What is the protein family that this protein belongs to?
Belongs to the KdsC family.
Protein: GUAA_CARHZ
Sequence: MASKVIVLDFGGQYSQLIARRIRELKVYCEMLPYNTPLEKIVQENPGGIVFSGGPSSVYGEGAPTVDPEIYRLNIPILGICYGMQLMAHQLGGIVRPAEGREYGKTPLFILNRDRLFAGLNETEICWMSHGDFVAKAPEGFLVTAKTEYTPIAAMENRERNLYAVQFHPEVVHTPKGKEILKNFLYEICGLTPDWTMESFAQKAIREIKEQVGEEKVVCALSGGVDSSVAAVLVHKAIGDNLTCIFVDHGLLRKGEAEEVVRTFKEQFQMNLVFVDAKEQFLAKLKGVRDPEQKRKIIGHEFIRVFEEEAAKLGDIRFLVQGTLYPDVVESGTATAATIKSHHNVGGLPEDMKFQLIEPLKWLFKDEVRELGLELGLPESIVWRHPFPGPGLAVRVLGEITEEKLAILREADYIFIDELKKSGWYRKTWQAFAVLPNLQSVGVMGDERTYAYTIALRAVTSEDGMTADWVRLPYELLEKISARIVGEVKGVNRVVYDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: CH60_STACT
Sequence: MAKEIKFSEDARQSMLRGVDQLANAVKVTIGPKGRNVVLDKEYGAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRKGIDKAVTEAVKSLHEQSQKVENKNEIAQVGAISAADEEIGQYISEAMDKVGNDGVISIEESNGFNTELEVVEGMQFDRGYQSPYMVTDSEKMEADLERPYILVTDKKISSFQDILPLLEQIVQSNRPILIIADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKSMLEDIAILTGAQFITDDLGYDLKDATVDMLGTANKVEVTKDNTTIVNGDGDKNSIDARVTQLKSQIEETNSDFDREKLQERLAKLTGGVAVIKVGAASETELKERKLRIEDALNSTRAAVGEGIVAGGGTALVNVYKQVSEIEAEGDVETGINIVLKALEAPVRQIAENAGLEGSIIVEKLKHAEPGIGYNAATDEWVNMLDAGIVDPTKVTRSALQNAASVAAMFLTTEAVVAKLPEENNDAGGPAMGGMSGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DLL2_XENLA
Sequence: MSGPYEKKMAVLTDLSTSSHPVTKDSPTLPESSATDMGYYNGHLSTGQHDFFQTQAYSPTISSYGYPHPPHPQYNFNGLVGNESFLPKDDYQYGYRPFVHYREPPVQETVSVKEEPETEVRMVNGKPKKIRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEGPDMEHSPNNSDSMACNSPSSPPIWDNSGSRTPLQQQQQQQSLPQCSSPSYLENYHSWYTQQNQSGQHLQPSEVMHQPPPDTVY
What is the function of this protein?
May have a regulatory function in the initial formation of the epidermis.
What are the official names of this protein?
Homeobox protein DLL-2, XDLL-2.
What is the protein family that this protein belongs to?
Belongs to the distal-less homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GPX2_CALJA
Sequence: MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCHQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPHDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLNVAI
What is the function of this protein?
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides.  Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
What are the official names of this protein?
Glutathione peroxidase 2, GPx-2, GSHPx-2, Glutathione peroxidase-gastrointestinal, GPx-GI, GSHPx-GI.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: NUOI_DECAR
Sequence: MGSMKEIFNSLFLKELLKGMSVTGKYFFARKITVQYPEEKTPQSFRFRGLHALRRYPNGEERCIACKLCEAICPALAITIEAEPRDDGSRRTTRYDIDLTKCIFCGFCEEACPVDAVVETRIFEYHGEKRGDLYYTKQMLLANGDRYEDQIAKDRELDASYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: COAD_PELUB
Sequence: MKKVAVYPGTFDPITFGHIDVINKALKLFDKVIIAASDGANKNYLFNSLERVQLIKKALFVDLKFDKKKIEVISFTSLTTDLCKKYKSNIILRGLRAVSDFEYEFQLAGMNRKLNNNIETIFLMSDVENQIISSRFVKEIVRLKGDIKKFTTKSTIKSLKEKYE
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUH2_RAT
Sequence: MMSDYNWFEGIPFPAISYQREILEDIRNKFVVKEEDLLILTYPKSGTNWLNEIVCLIQTKGDPKWIQTVPIWDRSPWIETEIGYPAIINKEGPRLITSHLPIHLFSKSFFSSKAKAIYLMRNPRDILVSGYFFWGNTNLVKNPGSLGTYFEWFLQGNVLFGSWFEHVRGWLSMREWDNFLVLYYEDMKKDTKGTIKKICDFLGKNLGPDELDLVLKYSSFQAMKENNMSNYSLIKEDRVTNGLKLMRKGTTGDWKNHFTVAQAEAFDKVFQEKMAGFPPGMFPWE
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics.
What are the official names of this protein?
Probable alcohol sulfotransferase, Androgen-repressible liver protein, Dehydroepiandrosterone sulfotransferase, DST, Hydroxysteroid sulfotransferase, ST, Senescence marker protein 2, SMP-2.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_SINFN
Sequence: MADQSIISALVLGLIEGLTEFIPVSSTAHVLLAGHFLGFKSPGNTFAVLIQLGAILAILLVYFQKLLSIALALPTSVKARRFVFSVLIAFLPAALIGAAAHGFIKAVLFETPMLICVVLIVGGVILYAIDRLPLQPRYTDVFDYPPSLALKIGLFQCLAMIPGTSRSGATIAGALLMGTDKRSAAEFSFFLAMPTMLGAFTLDLYKNRDALSFDDIGVIAIGFIAAFVAGIVVVRSLLDFVSHRGFTPFAIWRIVVGTAGLVGLWLVG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FLVC_ASPFN
Sequence: MDFGGILLHLEARSMATVLIAGLLVYWVGSAIFLAVLHPLAKFPGPKLAAASDWWLVYHEWFLGKSLTDILFDLHQNYGTINVPYGGLQDLWLDMDRIAYVVQSLTWESALEANSLVKLHFSSMQAYSDIYNVKSKWDKDPEVYKAIVDTSSAFGLRNYHEAKERRDLIWPFYSRQSVQRMQKAINRQISFLVDQLDKQNQEGKLSNMSMAFRCLAQDIMADICLGKSFGTLEERDFGSPLIHALDEGLESYVLMKSFPTLRNILYSISAMVTLPGEAEFATYGTIVADHVTRGIQQPDTIPPNTMLGFLVPTSSNTAKEAPQPKLSQGHMTEELQTFVIGAGETVASAMVQGLSGILQSPDLYKNVYEEIVQVWPETDGPVPPIEVLEKLPLLTAVIKEALRLTHGVVTPLARVISAGGACIDGHHVPGGTSVGTSHVFIHMSSDYYDAPDEFRPERWLGSSSDKHLVAFSKGPRGCMGINLAWCQLYLVLATLVRTVQMEYPADLNDIKIKWKDCFQPLYYGRPLQVRCTRAEGHS
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of flavunoidine, an alkaloidal terpenoid with a tetracyclic cage-like core connected to dimethylcadaverine via a C-N bond and acylated with 5,5-dimethyl-L-pipecolate (PubMed:31885262).  The tetracyclic core is synthesized by the terpene cyclase flvE and the cytochrome P450 monooxygenase flvD (PubMed:31885262).  The terpene cyclase flvE catalyzes the cyclization of farnesyl pyrophosphate (FPP) to form (1R,4R,5S)-(+)-acoradiene and the cytochrome P450 monooxygenase flvD is then responsible for oxidative conversion of (1R,4R,5S)-(+)-acoradiene into the tetracyclic cage present in the final product flavunoidine (PubMed:31885262).  In parallel, the N-methyltransferase flvH dimethylates L-lysine to give N,N-dimethyl-L-Lysin which is decarboxylated by flvG to afford dimethylcadaverine (PubMed:31885262).  The terpene cyclase-like protein flvF is the enzyme that attaches the dimethylcadaverine precusor at the C-7 of the tetracyclic cage to yield pre-flavunoidine (PubMed:31885262).  The cytochrome monooxygenase flvC hydroxylates the C-10 position of pre-flavunoidine whereas the NRPS flvI acylates the terpenoid core at the hydroxylated C-10 with dimethylpipecolate to yield final flavunoidine (PubMed:31885262).  The bifunctional enzyme flvA and the dehydrogenase flvB are responsible for the synthesis of the dimethylpipecolate precursor (PubMed:31885262).  The PLP-dependent lyase domain of flvA might use L-O-acetyl-homoserine and alpha-keto-isovalerate to form an intermediary ketone that can cyclize intramolecularly to yield an imine (PubMed:31885262).  The imine can be reduced by flvB to yield the 6-carboxylated pipecolate (PubMed:31885262).  The C-terminal alpha-KG-dependent oxygenase domain of flvA is then proposed to catalyze the decarboxylation to yield dimethylpipecolate (PubMed:31885262).
What are the official names of this protein?
Cytochrome P450 monooxygenase flvC, Flavunoidine biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YHIL_ECOLI
Sequence: MKAIDNQIRNISSSHQDKHSDKVNSHQHHGKVDKTHRAKIVEFDKLDNDSQIDNDFGLHIIYFLQHGHWKVNDRSHQMEKVWFYNSEPSIDIQEYNRFADNTTDTFIFTIIPDNNHVLKLSSPITVTVECKGGYYFINSSGDKSDIIYKVDGLSIIARNFFTLLSGNFKPDWRWDVSKETFTKEKFDSYVKSVFSKIDFYKQCGVINPQNANTAYFGDTDGRVGAVLYALLVSGHIGIREKGWSLLCELLKHEEMASSAYKHKNNKVLYDLLNTRDMILNELHQHVFLKDDAITPCIFLGDHTGDRFSTIFGDKYILTLLNSMRNMEGNKDSRINKNVVVLAGNHEINFNGNYTARLANHKLSAGDTYNLIKTLDVCNYDSERQVLTSHHGIIRDEEKKCYCLGALQVPFNQMKNPTDPEELANIFNKKHKEHMDDPLFHLIRSNTLKPTPVYANYFDNTTDFRPARERIFICGETLKGEDPSKYIRQKYGHHGPGVDHNQQFDNGIMGLNSLKEARDKNNKIIYSSGLSCFQLH
What are the official names of this protein?
Putative uncharacterized protein YhiL.