PharMolix/UniProtQA huggingface dataset:
Protein: PDXB_ECOLU
Sequence: MKILVDENMPYARDLFSRLGEVTAVPGRPIPVAQLADADALMVRSVTKVNESLLGGKPIKFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSSLLMLAERDGFSLHDRTVGIVGVGNVGRRLQARLEALGITTLLCDPPRADRGDEGDFRSLDELVQHADILTFHTPLFKDGPYKTLHLADEKLIRSLKPGAILINACRGAVVDNTALLTCLNEGQKLSVVLDVWEGEPELNVELLKKVDIGTPHIAGYTLEGKARGTTQVFEAYSKFIGHEQHVALDTLLPAPEFGRITLHGPLDQPTLKRLVHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVICDDASAASLLCKLGFNAVHHPAR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISDF_STAA8
Sequence: MMIKNKKKLLFLCLLVILIATAYISFVTGTIKLSFNDLFTKFTTGSNEAVDSIIDLRLPRILIALMVGAMLAVSGALLQAALQNPLAEANIIGVSSGALIMRALCMLFIPQLYFYLPLLSFIGGLIPFLIIILLHSKFRFNAVSMILVGVALFVLLNGVLEILTQNPLMKIPQGLTMKIWSDVYILAVSALLGLILTLLLSPKLNLLNLDDIQARSIGFNIDRYRWLTGLLAVFLASATVAIVGQLAFLGIIVHVVRKLVGGNYRVLIPFSTVIGAWLLLVADLLGRVIQPPLEIPANAILMIVGGPMLIYLICQSQRNRI
What is the function of this protein?
Part of the binding-protein-dependent transport system for heme-iron.  Responsible for the translocation of the substrate across the membrane (Probable).
What are the official names of this protein?
Probable heme-iron transport system permease protein IsdF, Iron-regulated surface determinant protein F, Staphylococcal iron-regulated protein G.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYL_ECOK1
Sequence: MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVKDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTEMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTCPEYKEGMLDSKAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTEDQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2526_BURO0
Sequence: MLSPCPILPSAECRDTADTPADPPGRVIPINRRRRRPGDWRPERPRERLLERGPAALTDDELIALLLGTGKPGHDVFVTARALVDQFGTLHGLLEATADDFEAHPGIGPARSARLVAVTEIARRMLVEKAEERMQIDSPGAVEDCLRLKIGTRQYEVFIAVYLDARNRLIDMEEIARGSLTRMAVYPREIVRRAMKHNAAALIVAHNHPSGAVQPSAEDRRLTRVLKDALELVDVRLLDHVVVGVSDTFSFARAGWL
What are the official names of this protein?
UPF0758 protein Bcenmc03_2526.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: ZAPA_GEOSW
Sequence: MAEQQKTRVTVDIYGQQYTIVGTESSSHIRLVASIVDDKMREISEKNPTLDISKLAVLTAINIVHDYIKLKEEYDRLLQKLHKEKDE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell. In sporulating cells, localizes near the cell poles.
Protein: CDI_ARATH
Sequence: MTISNGDVKSETCNNGSSEKKPFRIFVGYDPREDLAYQVCHHSITKRSSIPVEITPIIQSDLRKKGLYWRERGQLESTEFSFSRFLTPHLSDYQGWAMFVDCDFLYLADIKELTDLIDDKYAIMCVQHDYTPKETTKMDGAVQTVYPRKNWSSMVLYNCGHPKNKTLSPEIVNTQTGAFLHRFQWLEDEEIGSIPFVWNFLEGHNRVVEKDPTTQPKAVHYTRGGPWFDAWKDCEFADLWLNEMEEYNKENKKEADNAK
What is the function of this protein?
Probable nucleotide-diphospho-sugar transferase required for pollen germination and tube growth.
What are the official names of this protein?
Protein CDI, Protein CADMIUM INDUCED.
Protein: PNCB_SALPB
Sequence: MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVQVAAEFRCRGDDLLGIYADAIREQVDAMQHLRLQEDEFQWLSGLPFFKPDYLNWLREFRYNPAQVCVTNDNGKLNIRLTGPWREVIMWEVPLLAVISELVHHYRSPNAGVDQALDALESKLVDFTALTANLDMSRFHLMDFGTRRRFSREVQQAIVKRLQQESWFVGTSNYDLARRLALTPMGTQAHEWFQAHQQISPDLATSQRAALAAWLNEYPDQLGIALTDCITMDAFLRDFGIEFASRYQGLRHDSGDPVAWGEKAIAHYEKLGIDPLTKTLVFSDNLDLQKAVELYRHFASRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPQVRKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: VATH_DROME
Sequence: MTTALYLPEENIDMIAATSVLQQQAADIRTRTINWASYMQSQMISEEDYKAISALDKSRASFLAQNSSQVVKTLLNLVSHLSKDSTIQYILVLLDDLLQEDRSRVDLFHDTAGKLKQCIWGPFLNLLNRQDGFIVNMSSRILAKFACWGHETMPKSDLNFYLQFLKDQLASNNNEYIQSVARCLQMMLRVDEYRFAFVGVDGISTLIRILSTRVNFQVQYQLIFCLWVLTFNPLLAAKMNKFSVIPILADILSDCAKEKVTRIILAVFRNLIEKPEDSSVAKDHCIAMVQCKVLKQLSILEQRRFDDEDITADVEYLSEKLQNSVQDLSSFDEYATEVRSGRLEWSPVHKSAKFWRENAQRLNEKNYELLRILVHLLETSKDAIILSVACFDIGEYVRHYPRGKHVLEQLGGKQIVMQHLGHEDPNVRYEALLAVQKLMVHNWEYLGKQLEKENENQKQGAAPIAGKA
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit H, V-ATPase subunit H, Vacuolar proton pump subunit H, Vacuolar proton pump subunit SFD.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase H subunit family.
Protein: RODZ_ECOLU
Sequence: MNTEATHDQNEALTTGARLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPADLASTFLRGYIRSYARLVHIPEEELLPGLEKQAPLRAAKVAPMQSFSLGKRRKKRDGWLMTFTWLVLFVVIGLSGAWWWQDHKAQQEEITTMADQSSAELSSNSEQGQSVPLNTSTTTDPATTSTPPASVDTTATNTQTPAVTAPAPAVDPQQNAVVSPSQANVDTAATPAPTATITPDGAAPLPTDQAGVTTPAADPNALVMNFTADCWLEVTDATGKKLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEQSPAQ
What is the function of this protein?
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
What are the official names of this protein?
Cytoskeleton protein RodZ.
What is the protein family that this protein belongs to?
Belongs to the RodZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Forms helical filaments along the long axis of the cell.
Protein: H2AC1_CYRHA
Sequence: MKMTLIAILTCAAVLVLHTTAAEELEAESQLMEVGMPDTELEAVDEERLFECSVSCEIEKEGNKDCKKKKCKGGWKCKFNMCVEV
What is the function of this protein?
Postsynaptic neurotoxin.
What are the official names of this protein?
U4-theraphotoxin-Hhn1u, U4-TRTX-Hhn1u, Hainantoxin-II-29, HNTX-II-29.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYGA_RIPO1
Sequence: MSINFQEIIAKLHQFWSDRGCLIAQPYDTEKGAGTMSPHTFLRAIGPEPWSVAYVEPCRRPTDGRYGENPNRFQHYFQYQVLIKPSPDNIQDIYLDSLRVLGIHPEDHDIRFVEDNWESPTLGAWGVGWEVWLDGMEITQFTYFQQCGGIDCRPVSIEITYGLERLAMYLQDVEAITKIQWNNRVNYGEIFLQNEIEQCTYNFEASDPDLLLKLFNLYEQETKQLIEKGLVLPSLDYVLKCSHSFNLLDARGVIAVAERTRYIGRIRNLAREVAQLYLQQRETLGFPLCK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADD_HAHCH
Sequence: MQEHSPIVLLGGTFDPIHFGHLRTALELQQHFGESAEVRLIPCGDPRHRSAPKASGEHRLAMLRLALEGEPSLRIDEVEVRRTGASYTVDTLLELRQEVGNLRPLIFVMGTDAFESLPKWRRWLEIIQLAHIMVVNRPGWSFCEQGELGDFLRQHSAESNNDLIRQPAGKVGFITLTQMGISSSKVRELIGLRLSPRFLLPDSVWRYIRQHRLYGAVNA
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: CCA_ACTP2
Sequence: MQIYLVGGAVRDQLLNLPVKDRDYLVVGATPEQLLAQGYQQVGNDFPVFLHPKTKEEYALARQERKNGVGYNGFLCDFSPDVTLEQDLIRRDLTINAIAQDASGQIFDPYGGKQDLANRLLRHISPAFSEDPLRVLRVARFAARFHSLGFKIAPETVKLMQEMTACGELAHLTAERVWLETQKAFATDNPQIYFEVLREIGALAVLFPEFDRLFGVPQPEQHHPEIDSGVHTLLVIEQAKRLAKNAENPTALLWAALCHDLGKGLTEKDILPHHYGHEVKGVKPARELSNRLKVSTDVKDFAILVTEYHTHCHKMAELRPETVLKVFNALDIWRKPQRFCDFLLACEADARGRLGFENREYPQAELAKWYFKVAAQVDVQAVIQDGFEKKAIREELNKRRITAIKIIKPNV
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: AROB_CHLTB
Sequence: MIELVTDSPHPIHLVDSLQNPKLFASLSTDFPLIFITNTKLNTLILPPLLDLARSLGFSVETLTIPEGEETKTGDTFLSLHQQLTDLNVPRQATLIGVGGGVILDIAGFVAATHCRGMPFIAIPTTLVAMIDASIGGKNGINLNHIKNRIGSFYLPKAVWICPRKLSFLPQQELHHGIAECIKHAYIADSAILPLLQDPNALKKEDKLSLLIKKNCLCKASVVQQDVRDYAKRQILNFGHTLGHALEMLFIGKIPHSCAISVGMVLETKLSLSLGVARSPAILHSLIQDLLRYQLPVSLKDLYMRAQIPPHNCDQILSALTYDKKKQNTPLPPFVMIEEIGLAASFDGRFCQTISKHILTKVLEEEFYAMHNN
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_SYNPW
Sequence: MPAAFPVTAATPAGAEALDRLRHWPGEHRVAVGLSGGVDSSLTAALLVEAGWEVEGLTLWLMSGKGACCAEGLVDAAGICEQLEIPHHVVDSRDTFQREIVNGLIEGYQAGITPLPCSRCNRAVKFSPMLQWAQEKRGLARIATGHYARLRFDETTGRWRLLRGLDARKDQSYFLYDLTQEVLARVVFPLGELTKPDTRLEAARHGLRTAAKPESQDLCLADHHGSMRAFLDAYLPPRQGEIVLQDGTVVGEHDGIEHFTIGQRKGLGVAWSEPLHVVRLDAAMNRVVVATRDQAGRSHCVVGAINWVSMAPPAPEHSQMVQVQVRYRSAPVPARLTTMTAEASDAAAERPHRCRLDFDEPQFSITPGQAAVFYDGDAVLGGGLIQTSA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_HAEI8
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYTGSVKEAGGQVHRLEDWGRRQLAYPINKLHKAHYVLMNVEAPQQVIDELETTFRYNDAVLRSLVIHTKHAVTEASPMKAAKEERKPLAEVENNDFEDAEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: GGI1_STAHJ
Sequence: MQKLAEAIAAAVQAGQDKDWGKMGTSIVGIVENGISVLGKIFGF
What is the function of this protein?
Has hemolytic activity and also inhibits the growth of gonococci.
What are the official names of this protein?
Antibacterial protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal hemolytic protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: DOC10_MOUSE
Sequence: MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLDPLDYETVIEELEKTYRDDPLQDLLFFPSDDFSTATVSWDIRTLYSTVPEEAEHRAESLLVKEACKFYSSQWYVVNYKYEQYSGDIRQLPRAEHKPEKLPSHSFEVDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRKSAELAELGLDPLDNCVTCECTLEETDSSENSLHPDFAKYLTETEDTVKTTRNMGRLNLFSLDPDIDTLKLQKRDSFENELMIKPFEEKAAKRIMIICRALNFNLQGCVTENEYDPVTNIEPFFVSVALYDLRDNRKISADFHVDLNHPAVRQMLSGTPPALENGNIDTGTPRQSEEPHIKGLPEEWLKFPKQAVFSVSDPHSEIVLVAKVEKVLMGNIGSGAEPYIKNPDSNKFAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLYRQESSKMSSEDLLKLVSDYRRADRISKMQSIPGSLDIAVDNIPLEHPNCVTSSFIPVKPFNVSAQSEPTVEVEEFIYDSTKYCRPYRVYKNQIYVYPKHLKYDSQKCFNKARNITVCIEFKNSDDDGAKPMKCIYGKPGGPLFTSSAYTAVLHHSQNPDFSDEVKIELPTQLHGKHHLLFSFYHITCDINAKANAKKKEALETSVGYAWLPLMKHDQIASQEYNIPIATTLPPNYLSIQDPTSAKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSPTSSFVRACKNLLNVDKIHSIMSFLPIILNQLFKILVQNEEDEITATVTRVLADIVAKCHEEQLDHSVQSYIKFVFKTKSYKERTIHEELAKNLSDLLKSNDSTIVKHVLEHSWFFFAIILKSMAQHLIDTNKIQLPRAQRFPESYQSELDNLVMGLCDHVIWKCKEAPEETKRANHSVARFLKRCFTFMDRGFVFKMVNNYISMFSSGEFKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIRELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQTQTSMKHATSVDTSFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTTEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISDETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHTTSGHEGHKQHRSQTLPIIRGKNALSNPKLLQMLDNSMNSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQVHQRQLQQSDCQNSLMKRVFDTYMLFFQVNQSASALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRLTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKMEKICTPPLLPEDTQPCDSNLLLTTPGGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTVLTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSRKVSELNQLCTTEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSAIMNEQITGRDDPAKCGVERPYTTRVTSKGTAAVPVVSISSSAEV
What is the function of this protein?
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP.  Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway (PubMed:25851601).  Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression (PubMed:27502165).
What are the official names of this protein?
Dedicator of cytokinesis protein 10, Zizimin-3.
What is the protein family that this protein belongs to?
Belongs to the DOCK family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, dendritic spine.
Protein: AROA_YERPA
Sequence: MLESLTLQPIALVNGTVNLPGSKSVSNRALLLAALAEGTTQLNNVLDSDDIRHMLNALQALGVDFRLSADRTCCEVDGLGGKLVAEQPLSLFLGNAGTAMRPLAAVLCLGNSDIVLTGEPRMKERPIGHLVDALRQGGAQIDYLEQENYPPLRLRGGFRGGELTVDGRVSSQFLTALLMTAPLAEQDTTIRIMGDLVSKPYIDITLHLMKAFGIDVGHENYQIFHIKGGQTYRSPGTYLVEGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGAKVTWGDDYIECSRGELQGIDMDMNHIPDAAMTIATTALFATGPTTIRNIYNWRVKETDRLTAMATELRKVGAEVEEGEDYIRVVPPLQLTAADIGTYDDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQFARLSQLA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_BACC2
Sequence: MKKLLLVNGPNLNRLGVREVNVYGKGTLATLEADMKQEAETMGVELECFQSNHEGAIIDIIHEAEDIYEGIILNPGAFTHYSYAIRDAIASISIPVIEVHISNIHQRESFRHESVTAAVCAGQIVGFGFYGYKLALFALMEKLRGA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: SHKB1_BOVIN
Sequence: MAAAAPAVDGVPGRGPPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQLLEELDRSSCGNVLFTGYLPPPVFPVKRRNRHSLVGPQQAGGRPAPVRRSNTMPPNLGNAGLLGRMLDEKSPPSPSGLPEEPGMVRLVCGHHNWIAVAYTQFLVCYRLKEASGWQLVFSSPRLDWPIERLALTARVLGGALGEHDKMVAVATGSEILLWALQPEGGGSEIGVFHLGVPVEALFFVGNQLIATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCNNGSIYYVDVQKFPLRMKDNDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGGVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLISVCADSNHVRTWSVTRFRGMISTQPGSTPLASFKILALESADGHGGCSAGNDIGPYGERDDQQVFIQKVVPSASQLFVRLSSTGQRVCSVRSVDGSPTTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQAPAGGLTEEELMEQLEQCDLAPLASSRGSLPSPSPRTSLTSLHSAFSNTSLSSRRGSPSPPQAEARRRGGGSFVERCQELVRSGPEPRRPPTPAPRPSSGLGAPLVPPKTKLNETSF
What is the function of this protein?
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1.  Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
What are the official names of this protein?
SH3KBP1-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the KCTD3 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: HIS4_DEBHA
Sequence: MTKFRGCIDIHSGQVKQIVGGTLTQDDTTELNHKSTTTENFVSTKPSSYYAELYKNAGINGCHVIKLGSNPENDEAAKLACQSWPNNLQVGGGINGDNALEWLDVHKASHVILTSWLFSDSDEGKEFDWVKLKRVSELVGKSRLIVDLSCRELRVDDKIEWVVAMNKWQTLTNNKLSAEFLGEVSQYCDEFLIHAADVEGLCNGIDVNLVAKLGEWCPEGFEGKIVYAGGARSVKDLDTVSKLSDDKVDLTYGSALDVFGGKLVKFDDLVSWNELH
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, 5-proFAR isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YMF16_MARPO
Sequence: MNFVLKTILEEVRIRVFWILICFSFTWFTCYWFSEEFIFLLAKPFLTLPYLDSSFICTQLTEALSTYVTTSLISCFYFLFPFLSYQIWCFLMPSCYEEQRKKYNKLFYLSGFCFFLFFFVTFVWIVPNVWHFLYKLSTTSTNLLIIKLQPKIFDYIMLTVRILFISSICSQVPVLVICLLESKGVKTFIKNRRFFYSFFAFHSSFFYTPDIWCQIIACLPIYFIIELTIFYALIIQVYKKQLAL
What are the official names of this protein?
Uncharacterized tatC-like protein ymf16, ORF 244.
What is the protein family that this protein belongs to?
Belongs to the TatC family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: RNH2_YERPE
Sequence: MSETFIYPQANLIAGVDEVGRGPLVGAVVTAAVILDPNRPIVGLADSKKLSEKRRLSLYDEITEKALSWSLGRAEPEEIDQLNILHATMLAMQRAVSGLHIVPDYVLIDGNRCPKLQMPSLAVVKGDSRVAEISAASILAKVTRDREMTELDLLFPEYGFAQHKGYPTAFHLEKLAALGATVHHRRSFGPVKRVLGLV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_LISMF
Sequence: MKIDILSIFPDMFSGVTGNSIIKKAIENERVAVEVTDFREYAEGKHHIVDDYPYGGGAGMLLKAQPIFDAVQAVKEKQPETKPRVILMDPAGKRFDQKMAEEFAEEEHLVFICGHYEGYDERIREHLVTDEVSIGDYILTGGEIGAMIVMDSVIRLLPGVLGNKDSAVTDSFSTGLLEHPHYTRPADFRGMKVPDILLSGNHAWIEEWRDKESLKRTYERRPDLLKNYPLTDKQKTWLKEWSDSK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTJA_ECO24
Sequence: MFRWGIIFLVIALIAAALGFGGLAGTAAGAAKIVFVVGIILFLVSLFMGRKRP
What are the official names of this protein?
UPF0391 membrane protein YtjA.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: INSE5_ECOLI
Sequence: MTKTVSTSKKPRKQHSPEFRSEALKLAERIGVTAAARELSLYESQLYNWRSKQQNQQTSSERELEMSTEIARLKRQLAERDEELAILQKAATYFAKRLK
What is the function of this protein?
Involved in the transposition of the insertion sequence IS3.
What are the official names of this protein?
Transposase InsE for insertion sequence IS3E.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.
Protein: QUEA_YERP3
Sequence: MRVADFSFELPEALIAHYPQPQRSGCRLLSLDGPTGTLTHGIFTDLLDKLAPGDLLVFNNTRVIPARLFGRKASGGKLEVLVERVLDDHRVLAHVKASKAPKPGAELLLGDDENIRATMLARHDTLFELRFDDERDVFTILNAVGHMPLPPYIDRPDEDADRELYQTVYSQRPGAVAAPTAGLHFDEPMLAALQEKGIEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQEVVDAVLACKARGKRVVAVGTTSVRSLESAAKAAENGLIAPFFGDTRIFIYPGYHYQVVDALVTNFHLPESTLIMLVSAFAGYKNTMNAYQQAVAEQYRFFSYGDAMFISRNPRAPQEKVSP
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_PASMU
Sequence: MSKTLYEKLFDAHVVHEANGETPLIYINRHLVHEVTSPQAFDGLRAMGRSVRQPSKTVATMDHNVPTDSRDLAGSGEMGRVQMVELAKNTEQFGITLYDINHINQGIVHVMGPEQGLTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTIKQARAKKMKIEVRGKVRDGISAKDIVLAIIGKTTMGGGTGHVVEFCGEAIRDLSMEGRMTVCNMAIELGAKSGIIAPDETTFAYLKDKPYAPKGKDWDEAVAYWQTLHSDEGAEFDTVVTLEASEIEPQVTWGTNPGQVIGINQPIPNPAEMSDPIERQSAEKALAYMDLPHSIKLTDVAIDKVFIGSCTNSRIEDLRAAAAIAKGRKVADGVQALVVPGSGLVREQAEKEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLAPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVYGKFVDIRNLELH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.