PharMolix/UniProtQA huggingface dataset:
Protein: HDAC3_CHICK
Sequence: MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPNNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYALNVPLRDGIDDQSYKHLFQPVINQVVDYYQPTCIVLQCGADSLGRDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVDEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPSDLLSYDRTDEPDPEERGSEENYSRPEAANEFYDGDHDNDKESDVEI
What is the function of this protein?
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates.  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression.  Also functions as deacetylase for non-histone targets.  In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively.
What are the official names of this protein?
Histone deacetylase 3, HD3, Protein deacetylase HDAC3, Protein deacylase HDAC3.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RR14_LOLPR
Sequence: MAKKSLIQREKKRQKLEQKYHLIRQSLKKKIRSKVSSLSLSEKTKMREKLQSLPRNSAPTRLHRRCFLTGRPRANYRDFGLSGHVLREMVYECLLPGATRSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YOBH_ECOLI
Sequence: MRFIIRTVMLIALVWIGLLLSGYGVLIGSKENAAGLGLQCTYLTARGTSTVQYLHTKSGFLGITDCPLLRKSNIVVDNG
What are the official names of this protein?
Uncharacterized protein YobH.
Protein: Y2617_LISIN
Sequence: MASKQLKLVIITGMSGAGKTVAMQSLEDLGYFCVDNLPPSLLPKFWELMKESDKMDKIALVMDLRGREFFDSIEPALDELDNTNFITTKILFLEADDKVLVSRYKETRRHHPLEPNGSVLDGINAERELLSDLKGRSQLVINTSNMAPRELRERINNEFQTEDKDVFNVQLMSFGFKYGIPIDADLVFDVRFLPNPHYIDKMRPLTGLDEDVYEYVMKWPETMAFLDKLVDLLMFTLPFYKREGKTQLVIAIGCTGGQHRSVALTEYVGKAIQQKYETTISHRDMKRRKER
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein lin2617.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: PA2BA_PSEAU
Sequence: NLIQFSNMIQCANKGSRPSLHYADYGCYCGWGGSGTPVDELDRCCKVHDDCYDQAGKKGCFPKLTLYSWDCTGNVPICNPKSKCKDFVCACDAAAAKCFAKAPYNKANWNIDTKTRCK
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 PA-10A, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HISZ_BACMK
Sequence: MTKWKRANPNGTRDYLFEECTLIEEVEQKLRRTFLERGYEEIRTPTIEFYDVFAFQNRPIDEEKMYKFFDEKGRIIVLRPDMTIPLARVIGTQRGDIPLKVTYSGNVFRANESLTGKYNEIVQSGIEIIGIENVRAEIECVISVIQALQKLKVQSFTIEIGQVQLYKCIVKKLPINDEEEKLLRTYIESKNYAALSHFIEEKKLNRCDETVRLLEKLPRLFGSLDVVEEAEKLASSNEMKMAIARVKEIYETIEQLGYGSYISIDLGMVQHLDYYTGVIFKGYIYEIGEEIVSGGRYDELIGNFGEMMPAVGLAVQVNQIVKALQEQQEPYKRKRIDIMIHYELNRLAEAERLRNLLQKDGKNAQLSLFSNLNDTFQFANKNKIMTVVEAKSESLVEYVWREKWIIQKEGEASCVTFKLR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SGCC_STRGL
Sequence: MPHGAEREASPAEESAGTRPLTGEEYLESLRDAREVYLDGSRVKDVTAHPAFHNPARMTARLYDSLHDPAQKAVLTAPTDAGDGFTHRFFTAPRSVDDLVKDQAAIASWARKSYGWMGRSPDYKASFLGTLGANADFYEPFADNARRWYRESQEKVLYWNHAFLHPPVDRSLPADEVGDVFIHVERETDAGLVVSGAKVVATGSALTHAAFISHWGLPIKDRKFALVATVPMDADGLKVICRPSYSANAATTGSPFDNPLSSRLDENDAILVLDQVLIPWENVFVYGNLGKVHLLAGQSGMIERATFHGCTRLAVKLEFIAGLLAKALDITGAKDFRGVQTRLGEVLAWRNLFWSLSDAAARNPVPWKNGTLLPNPQAGMAYRWFMQIGYPRVLEIVQQDVASGLMYVNSSTEDFRNPETGPYLEKYLRGSDGAGAVERVKVMKLLWDAVGSDFGGRHELYERNYSGNHENTRIELLLSQTASGKLDSYMDFAQACMDEYDLDGWTAPDLESFHAMRSASRDLLGGL
What is the function of this protein?
Oxygenase component of a two-component system involved in the biosynthesis of the enediyne antitumor antibiotic C-1027 (PubMed:18426211).  Uses FADH(2) supplied by SgcE6 to catalyze the C-5 hydroxylation of (S)-3-chloro-beta-tyrosyl-S-SgcC2 (PubMed:18426211).  Can also efficiently catalyze the regioselective hydroxylation of other 3-substituted beta-tyrosyl-S-SgcC2 analogs, including the bromo-, iodo-, fluoro-, and methyl-substituted analogs, but does not accept 3-hydroxy-beta-tyrosyl-S-SgcC2 as a substrate (PubMed:18426211).  Is only active with SgcC2 (peptidyl carrier protein)-tethered substrates (PubMed:18426211).
What are the official names of this protein?
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase, Antibiotic C-1027 biosynthesis two-component monooxygenase system, oxygenase component.
What is the protein family that this protein belongs to?
Belongs to the FADH(2)-utilizing monooxygenase family.
Protein: PRDX6_MOUSE
Sequence: MPGGLLLGDEAPNFEANTTIGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNGETPTEKLPFPIIDDKGRDLAILLGMLDPVEKDDNNMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTGTKPVATPVDWKKGESVMVVPTLSEEEAKQCFPKGVFTKELPSGKKYLRYTPQP
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity).  Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity).  Has phospholipase activity (PubMed:26830860).  Can either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity).  These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity).  Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity).  Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860).  Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity).
What are the official names of this protein?
Peroxiredoxin-6, 1-Cys peroxiredoxin, 1-Cys PRX, Acidic calcium-independent phospholipase A2, aiPLA2, Antioxidant protein 2, Glutathione-dependent peroxiredoxin, Lysophosphatidylcholine acyltransferase 5, LPC acyltransferase 5, LPCAT-5, Lyso-PC acyltransferase 5, Non-selenium glutathione peroxidase, NSGPx.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome. Note=Also found in lung secretory organelles (lamellar bodies).
Protein: YCF3_SYNE7
Sequence: MPRTQRNDNFIDKSFTVMADLILKVLPTNKKSKEAFAYYRDGMSAQADGEYAEALENYQEALTLEEDPIDRSFILYNIALVHTSNGDHQTALDHYLQALDLNPKMPQALNNIAVIHHFLGQRSEEAGNDDEAERHYDQAAEYWTQAIRLAPNNYIEAQNWLKTTGRSKVDVYF
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: RPOB_PELHO
Sequence: MLGDRNEGMATIPALNQIQFEGFCRFLDQGLIEELSQFPKGNSFLEYFRDEEIDFQLFSKTYHLVKPLIKERDARYESLTYSSKLYVSAGFLWKDKRPQKKTICIGNLPLMNSVGTFIVNGISRVVINQILQSPGIYYGSELDYQGFTVYIATIISDWGGRLKLEIDKKERIWARVSRKQKISILVLSSAMGSNLKEILENACYPEIFLALNLKKECGFKEKKYAILELYAKYKDFTEYKDSLDFDFLCETLRKTFFSHKCELGRVGRQNINRRLNLDISHKNTFLLPQDILAATNHLIGMKFGMGTLDDMNHLKNKRIRSVADLLQDQFGLALNRLEDAVCDTIGRAIAKDKIPTLRHLATSTPLTTTYESFFKLHPLSHVFDETNPLTHIVHGRKWSFLGPGGLTERTARFRVRDIHPSNYGRICPIDTSEGIKVGLIGYLATHARIGDCGSLESPFYEMSEKSKRVRMLSLSSRKEEYYMIGTGNSLALNQGIQEEQIIPARYRQEFLTIAWEEVHFRSVFPFQYFSIGVSLIPFLEHNDATRALMSSNMQRQAVPLSRSEKCIVGTGFEGQVALDSGIPLITEHAGKIISTHTDKILLSVNGETLSSPLVLFQRSNKNTWIHQTPQVSRGNCTKKGQILADGAATVGGELALGKNVLVGYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKCEIKIFMTMKGPEKITNQIPHIDPHLLRNLDKNGVVILGSWVEAGDILVGKLTPELVELSPEKRLIEALFDAPIGTTRQSCLKLPIWGRGRVIDVRWIHKGSASRSNPERIRVYILQKRKIKVGDKVAGRHGNKGIVSKILPIQDMPYLQDGRPLDMVFNPLGVPSRMNVGQIFECSLGLAGGLLDRHYRIAPFDERYEEEASRKLVFSELYEASKQTGNPWVFEPEYPGKSIIFDGRTGDPFEQPVIVGQSYILKLIHQVDDKIHGRSTGPYSRVTQQPVKGRARRGGQRVGEMEVWALQGLGVAHILEEILTYKSDHLTTRNQIFGTLLLGGALPKPEPEDRPESFRLLVRELRSLSLELNYFLVSKNKKNFNFWKMNRVEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL361_YERPY
Sequence: MKVRASVKKLCRNCKIVKRNGVVRVICSAEPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: Y1302_XANCP
Sequence: MIKWAIIFAIIGLIAGALGFGGMAGAAMGIAKFLFWAGIIIAIVLFVLGMTIAKKVT
What are the official names of this protein?
UPF0391 membrane protein XCC1302.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HXK_TOXGO
Sequence: MQPRQPGDEAKQLAELEVVRQMMTPTREVLLELHESFLKELQRGLEMHKRHGITWVPEECSMKMLDSCVSNLPTGAEVGEAYAIDFGGSTCRAVRCSLLGKGKMEIIQDKICLRSAEHRCAKGFMDKKAGGKELFDQFAMCIRGLMDRSGDLKKAEETNTPVPVGFTFSFPCAQAALNSSFLIEWTKGFETGRENPDRVEGKDVAVLLADALQRHNVPAVCKAIVNDTVGTLVSCAYQRVPGTPECRVGLIIGTGFNACYVEPEASNYGYTGTVVNMEAGNFHKDLPRNEIDVEVDEKTHNRGKQQFEKLVSGYYIGEIVRVAAVRVFGARAPEKASVRHSIHGETASTIRDDHSQDKAASIQAIKECWGVTMDLDDIKCIWEICRLVFDRSAAFAATLAVALCYRTGRLDTGSTVGIDGALYVKNQWYREAVEYYTKLVAGDAAKNIHYCIADDGSGKGAALIADVN
What is the function of this protein?
Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.
What are the official names of this protein?
Hexokinase.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
Protein: KI26L_CAEBR
Sequence: MEACTSKSSLLLHSPLRTIPKLRLCTTISSEDVAYGRCNLTDQHLQIEGKNYSKNTFDHIFRTDATQDDMYSAFLSDMINSVFAGNDATVLAMGAKANGKDERLYGNSVSRNGLIQMAITQLMNAIDDNKDPEERIQVRMSAIMVSQKDSSIVDLLSPFNDPRHRVVKLVDDARTGVFLDNESEIRVETIDQALFYLNTAVDHRLIQDEQTHRTSHVFISLSLYSYKMGDKMQGGRRRLCFLDMGIGERNSTNGGMTMPALGSILLAMVQRNKHIPSRDSSVCQLIRCALSTSRFTTFLFSFGSKNDDNENIAHLACKIARTRVKSVMGHGRKPSGTFSSGTMDSNGSSSSFGTTTITPGGTPRTQRRFELESGSELSAAETVIFLGPSCSRTTSPASTTMPSTPTSIRPLHRTTRNHSGVDPVSKPLSVETKSSPTHNCHDGCIHSIPPMLRGHTPFLSPHLKLYDELCSPPNSSCASPVLSAPNAFGGKTAERRDDFGIMIAQPHIPLMKAKSKYNLDDGKMKQIMQWMETSEAPPILFSSPCYENSATSLDELRECVGILSHPLEDIIEQEEESMRTSTATTGGSKKDHPLRILSKQDLNIDSEAKDKDETELELVMAASLSSMRSHDILAKLEAMRNAQSGQNGQNGNIGTSQSNTDMDVSEMDMYRRASHLEEYAMQRVREIEDNKMKNKKKVKLGLNCCQQQSMISSGSTVVDWSQIERKKEREKDAMEEEKRKEVLRERRAKLKITELEIKRERNMIDKELDDKKGIANSIARQLQHFSLSPCRGGRTHRSVSTHRIDPPNASLPSTPTMSHKKMIGGSLAKLSASGASGSGPPSSPSLGYHQSLPRHSKLPTAVNGRRSSAERDRKTSKNSRNASSKERRSSGSKEELQWRSPYAQMTSPKTYGGPGTSSSGRGSSAPGSDFETPVVSATEKTANGTMPRSKRQSYSASSGYESANDYHIYATTNKKANILEKKRNEEKLFLVRQADEIRHRQWQLKKELEEAKRAIGQEEDAKMIANSSDQRLNGLSRTTMVDAMLQENRILEKRLIACRNHSMLVTTFI
What is the function of this protein?
Required for posterior migration of cells and axon growth cones during nervous system assembly (By similarity).  In PLM neuron, regulates innexin unc-9 gap junction turnover by suppressing unc-9 transport out of the gap junctions (By similarity).
What are the official names of this protein?
Kinesin-like protein vab-8, Variable abnormal morphology protein 8.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: UNG_PSEPK
Sequence: MTDDDRIKLEPSWKAALRGEFDQPYMHQLREFLRGEYAAGKEIYPPGPLIFNALNSTPLDQVKVVILGQDPYHGPGQAHGLCFSVQPGVATPPSLVNIYKELQRDLNIPIPSHGYLQSWAEQGVLLLNTTMTVERANAASHAKKGWELFTDRIIQVVSEQCPNVVFLLWGAHAQSKQKLIDGTKHLVLKSVHPSPLSAYRGFIGCGHFSRANSFLEQRGLGPIDWALPPL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GS17_XENLA
Sequence: MSQNLDFLALAGRGGPHYASPTSRHPSPKVWNSTPPSLERGPSERQISPTPDQYTNPNRRRQPWKDWSPGRWQLLQNQRQSWGLSPTAPTRHKRTPEPKPFFRQPRGGATQVYGNHQPGSYRDISHYYSPSMLEDPWAALQAEAQYR
What are the official names of this protein?
Gastrula-specific protein 17.
Protein: ISPDF_RHIL3
Sequence: MLQMPSKQPISAGIVIVAAGRGERAGSSKEGPKQYRMIGGKPVIVHTLENFMTWEAATEIVVVIHPDDEALFARAFRHIISATPIETVHGGATRQQSVLAGLRYLKDKQISHVLIHDAVRPFFDHALLDRIAESLDAGAQAVLPAIPVTDTLKRADNAGTVLTTVSREHLYAAQTPQSFAFETILEAHEKAAASGRSDFTDDASIAEWLGIPVTIVEGTADNVKLTVKDDIAMADDKLSASLLPDVRTGNGYDVHQLVAGDGVTLCGVFIPHDQKLKGHSDADVALHALTDALLATCGAGDIGDHFPPSDPQWKGAASRIFIEHAARIVRERGGTIMNADVSLIAEAPKVGPHRDAMRAKLSDYLGIDIERCSVKATTNETIGFVGRREGIAAIATATVVYRGRK
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: EFTU2_SHESR
Sequence: MAKAKFERNKPHVNVGTIGHVDHGKTTLTAAISHVLAKTYGGEAKDFSQIDNAPEERERGITINTSHIEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVASTDGPMPQTREHILLSRQVGVPFIIVFMNKCDMVDDAELLELVEMEVRELLSEYDFPGDDLPVIQGSALKALEGEPEWEAKIIELAEALDSYIPEPERDIDKPFLMPIEDVFSISGRGTVVTGRVERGIVRVGDEVEIVGIRTTTKTTCTGVEMFRKLLDEGRAGENCGILLRGTKRDDVERGQVLSKPGSINPHTTFESEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLICPIAMDEGLRFAIREGGRTVGAGVVAKIIA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNF_PENHR
Sequence: MSAPTQTTPVFKALTEASFSDSSLSEEAKQNALYWWNTSANDLARMLHQADYSEEVQRGFLSYYRDNICPRLGGKPDKDSADSGVGWDGNPLEYSFELKGSTKKKSVRFVVDLTELRPADHSNPLSMKHTQEMVDLLAEKTPNFDDTWYKVLKNWFVYAHLTPEEQTALIAKAGQQTSVIIGFDIYPKLTSPDQLPVMGKVYFPPCYVASDKGISRWQAVRQGIQSLPGVESFPNILSSTEIINDYLSEKPDSWQMGTRYLATDLVSPNKARFKVYMRCFDTSFEGIWDYYTLGGRIPNLDEDREKFRQLMDLVSGTTYAETRSKDDMQMGRFTSATGKLTAIYFNISPDNPYPAPKLCIYPSNFAKDDEVIAKGLDEWLEKYGWSDDTKSMEDQVKSVFDHRKLEETTGIFTFIGIGRKEDPTKKELSIQVYMTPELYRTPRY
What is the function of this protein?
Prenyltransferase; part of the gene cluster that mediates the biosynthesis of phenalenones such as herqueinone, compounds that have been reported to treat tumors, bacterial infections and/or mycoses, and rheumatic diseases (PubMed:26978228).  The non-reducing polyketide synthase phnA synthesizes the heptaketide backbone and cyclizes it into the angular, hemiketal-containing naphtho-gamma-pyrone prephenalenone.  The product template (PT) domain of phnA catalyzes only the C4-C9 aldol condensation, which is unprecedented among known PT domains (PubMed:28240554, PubMed:26978228).  The transformation of prephenalenone to phenalenones requires an FAD-dependent monooxygenase phnB, which catalyzes the C2 aromatic hydroxylation of prephenalenone and ring opening of the gamma-pyrone ring simultaneously (PubMed:28240554, PubMed:26978228).  Subsequent intramolecular deprotonation of C3 phenolic oxygen accelerates phenalenone ring closure to yield the tricyclic phenalenone core with a C2 hydroxylation (PubMed:28240554, PubMed:26978228).  The prenyltransferase phnF further catalyzes reverse C-prenylation of phenalenone by direct electrophilic substitution at C6, or possibly via first a forward O-prenylation of a neighboring phenol in phenalenone, followed by a Claisen rearrangement (PubMed:28240554).  The hydroalkoxylation enzyme phnH catalyzes the 5-exo-trigcyclization via acid catalysis after the spontaneous deprotonation of 7-OH, which leads to the formation of the dihydrobenzofuran atrovenetin (PubMed:28240554).  Atrovenetin is further converted to deoxyherqueinone by the O-methyltransferase phnC which can methylate C2-OH to stabilize the northern portion of the phenalenone core (PubMed:28240554).  Finally, the oxidoreductase phnG converts deoxyherqueinone to herqueinone via C6 hydroxylation (PubMed:28240554).
What are the official names of this protein?
Prenyltransferase phnF, Phenalenone biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: MENG_LISMF
Sequence: MTETKEEKVHKVFEKISPSYDRMNSVISFKLHVKWRKETMKLMRVQKGTNVLDVCCGTADWSIMMAEEIGPEGHVTGLDFSENMLKVGREKVKEADLHNVELIHGNAMELPFPDNSFDYVTIGFGLRNVPDYMQVLREMYRVLKPGGQLACIDTSQPNIPGWKQVFNAYFRYVMPVFGKFFAKSYKEYSWLQESTREFPGMARLAEMFQEAGFSYVRYISHSGGASATHFGFKKKEQ
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: TORL1_ARATH
Sequence: MRSQTASKTSMKPSSNSSAFSVRSSVAVSSHSAMVELKQRILTSLSRLGDRDTYQIAVDDLEKIVVSVPDSPEILPVLLHCLFDSSSDLKAPVKRESIRLLSFLCLSYTDLSFSQLAKIISHIVKRLKDADNGVRDACRDAIGSLSAQFLKEKEVENGNYVGSSLVGLFAKPLFEAMAEQNKSLQSGAAICMGKMIDSATEPPVAAFQKLCPRISKLLNSPNYITKASLLPVVGSLSQVGAIAPQSLESLLHSIHECLGCTNWVTRKAAADVLISLAVHSSSLVADKTDSTLTALEACRFDKIKPVRESLSEALNVWKNIAGKGESGTMDDQKDVSSEQCILERNGETDSVSCEEAGLVMQGSCDGLSSSSDSISKAVLILRKKAPRLTGKDLNPEFFQKLEKRGSGDMPVEVILPSRQKNSSNSNTEDESDANTSVLRSRSNGLCRTAGVHTKQRHFGDFAREKWVDERMNGGESRLRAFDGDHTEVIQADTSENRGNWPPLQRQLLHLERQQTHIMNMLQDFMGGSHDGMISLENRVRGLERIVEEMSREMSIQSGARGKATASWRSDVDGWDSPNYGPSSRNTQTSTRKIRGTGPSEQSGNSRRAWDKSSVAIRLGEGPSARSVWQASKDEATLEAIRVAGEDCGTSRNRRVSIPEAEAMMDEDDDNRGGQQGDPIWTCWSNSVHALRVGDTDSAFAEVLSTGDDHLLVKLMDKTGPVLDQLSSDMGNEAIHSIAQFLLDHTLYDICLSWIQQLLEVSVENGADFMGIPLELKKELLLNLHEALSTTDPPEDWEGLAPDHLLVELASNWNIEIQHFDT
What is the function of this protein?
Plant-specific microtubule-associated protein (MAP) that regulates the orientation of cortical microtubules and the direction of organ growth.
What are the official names of this protein?
TORTIFOLIA1-like protein 1, Microtubule-associated protein SPIRAL2-like.
Protein: ASSY_HISS2
Sequence: MSNTILQHLPIGQKVGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYNAIPRKAMEYGAEKARLIDCRNQLAHEGIAAIQCGAFHISTGGVTYFNTTPLGRAVTGTMLVSAMKEDDVNIWGDGSTFKGNDIERFYRYGLLTNPSLRIYKPWLDNQFIDELGGRQEMSEFLIANGFDYKMSAEKAYSTDSNMLGATHEAKDLEYLNSGIRIVKPIMGVAFWRDDVTVKAEEVTVGFEDGVPVTLNGQSFSSAVELFLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTAIHNEDTIEQYRINGLRLGRLLYQGRWFDPQALMLRETAQRWVARAVTGEVTLELRRGNDYSILNTVSPNMTYHPERLSMEKVENAPFDPSDRIGQLTMRNLDITDTRDKLGIYTHTGLLTVGKDSMLPQLDKK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUR52_RANRN
Sequence: GLMSSIGKALGGLIVDVLKPKTPAS
What is the function of this protein?
Has antimicrobial activity against L. lactis and S. uberis.
What are the official names of this protein?
Aurein-5.2.
What are the subcellular locations of this protein?
Secreted.
Protein: TTHY_TILRU
Sequence: MGSSSLLLVCLAGMVYLTEAAPLVSHGSIDSKCPLMVKVLDAVRGRPATSIAVKVSKMSEEGDWKEFANGKTNEFGEIHELTTDEQFVQGLYKVEFDTSSYWKALGVSPFHEYADVVFSANDSGHRHYTIAALLSPFSYSTTAVVSDPKE
What is the function of this protein?
Thyroid hormone-binding protein.  Probably transports thyroxine from the bloodstream to the brain.
What are the official names of this protein?
Transthyretin, Prealbumin, TBPA.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL32_SYMTH
Sequence: MAVPKRKVSKSRRDSRRAQTFRLEAPNLSPCPNCRTPRLPHRVCPNCGYYQGRVVIQHEAEAAE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: Y120_STACT
Sequence: MRGGGNMQQMMKQMQKMQKKMAEEQEKLKDEKVEGSAGGGMVKVVVTGHKEVVDVVIDEEAVDPDDVEMLQDLVLAATNEAMNKADELTSERLGKHTKGLNIPGM
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Sca_0120.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: GATC_CUPTR
Sequence: MALDLSDVKRIAHLARIETSDDEAAQTLAQLNNFFSLVEQMQAVDTTGIEPQAHPLSAVRDMVQRLREDVVTETDRRADYQRPAPATENGLYLVPKVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.