PharMolix/UniProtQA huggingface dataset:
Protein: NTPPB_SHESR
Sequence: MTPQLILASTSVFRQALLQKLGLAFGSCNPDIDESPMTNESAQDLVLRLAKAKTKAGATHFPHGLIIGSDQVAVIDGKIIGKPLNRENAIKQLSQASGKVITFYTGLALYHAETGEMNAQVEPFTVHFRQLSAAQIAAYVDKEQPFYCAGSFKSEGLGIALFNRLEGRDPNTLIGLPLILLTEMLLNQGIDVLAD
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_MYCTA
Sequence: MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFARNGEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRDAEAYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKGEKEQRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKGTSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRITQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTIPTKRSETFTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTFDIDANGIVHVTAKDKGTGKENTIRIQEGSGLSKEDIDRMIKDAEAHAEEDRKRREEADVRNQAETLVYQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDISAIKSAMEKLGQESQALGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREAK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PHLA_MYCTU
Sequence: MSASPLLGMSRREFLTKLTGAGAAAFLMDWAAPVIEKAYGAGPCPGHLTDIEHIVLLMQENRSFDHYFGTLSSTNGFNAASPAFQQMGWNPMTQALDPAGVTIPFRLDTTRGPFLDGECVNDPEHQWVGMHLAWNGGANDNWLPAQATTRAGPYVPLTMGYYTRQDIPIHYLLADTFTICDGYHCSLLTGTLPNRLYWLSANIDPAGTDGGPQLVEPGFLPLQQFSWRIMPENLEDAGVSWKVYQNKGLGRFINTPISNNGLVQAFRQAADPRSNLARYGIAPTYPGDFAADVRANRLPKVSWLVPNILQSEHPALPVALGAVSMVTALRILLSNPAVWEKTALIVSYDENGGFFDHVTPPTAPPGTPGEFVTVPNIDAVPGSGGIRGPLGLGFRVPCIVISPYSRGPLMVSDTFDHTSQLKLIRARFGVPVPNMTAWRDGVVGDMTSAFNFATPPNSTRPNLSHPLLGALPKLPQCIPNVVLGTTDGALPSIPYRVPYPQVMPTQETTPVRGTPSGLCS
What is the function of this protein?
Involved in virulence (PubMed:20736081).  Induces cytotoxic effects on mouse macrophage cell lines, via direct or indirect enzymatic hydrolysis of cell membrane phospholipids (PubMed:20736081).  Hydrolyzes phosphatidylcholine and sphingomyelin (PubMed:8757862, PubMed:20736081).  Does not have hemolytic activity (PubMed:20736081).
What are the official names of this protein?
Phospholipase C A, PLC-A, MTP40 antigen, Mycobacterial phospholipase C A.
What is the protein family that this protein belongs to?
Belongs to the bacterial phospholipase C family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Remains associated with the cell.
Protein: SPP24_ONCMY
Sequence: MKWCVLMLALLQSLCCSGLPLYQSELASTADKALVVTMTQVNNLYAGLRLYRVTRGSIKRVVPLGLNTYDLMMNFGIKETDCLKSSGEDPQRCAFRVGFFVPAASCTARVRVTAELTQVVSLNCGQDSSSSESSSEENFTRKRQQLNVQPSGNRGPVLPGFSEATLFPSHSFSRQVEPQPIPRGDSIGNHLE
What is the function of this protein?
Could coordinate an aspect of bone turnover.
What are the official names of this protein?
Secreted phosphoprotein 24, Spp-24, Secreted phosphoprotein 2.
What is the protein family that this protein belongs to?
Belongs to the SPP2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PAGR1_RAT
Sequence: MSLALGHGTIAGSTAAPLSEEGEVTSGLQALAVEDTGGPSVSASKAEEEGKGSQEEAGREASRAEEALEASSAVSDERAEGESEDWCVPCSDEEVELPANGQSWMPPPSEIQRLYELLATQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEGPSPASPPLRSSGNSLFPRQRKY
What is the function of this protein?
Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation.  However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex.  Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex.  However, its function in DNA damage has been questioned.  During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex.  Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition.  Acts as transcriptional cofactor for nuclear hormone receptors.  Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent.
What are the official names of this protein?
PAXIP1-associated glutamate-rich protein 1, PAXIP1-associated protein 1, PTIP-associated protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSA3_CANAL
Sequence: MAASDAHNNNKKRSNRRRKKRRTEDFSSSSESSSSSSSESDHEDLDEPEKEISKQDINIDDIDIESDNENSALTNDKGNKLIPQNLSITEKQQLSTVPFTTTSISNITNDNQIKNTPNINEISKNLDQKKTQLNNEFLKIMTTEFGDDLDELRKKPDFTEKSLVILAKTLQSGVNMFDIDVLNGLIQESGNTSNQ
What is the function of this protein?
Required for efficient biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Ribosome assembly protein 3.
What is the protein family that this protein belongs to?
Belongs to the RSA3 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: Y4424_PSEAE
Sequence: MTDRESSRDKGRQAEELACAHLRRQGLATLGKNWTCRRGELDLVMLDGDTVVFVEVRSRRHRAWGGALESIDARKRQRLILSAELFLQQEARWAKRPCRFDVVTVDTSDGQSPPRLDWIQNAFDA
What are the official names of this protein?
UPF0102 protein PA4424.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: FOLD_PHOPR
Sequence: MAAQIIDGKLIAQTVRQEVAARVKARVEAGLRAPGLAVVLVGQDPASQIYVSSKRKACEEVGFISQSFDLPANTKEIELLALINELNTNKEIDGILVQLPLPAGIDTTNILEHIDPEKDVDGFHPYNVGRLSQRIPKLRSCTPKGIITLLERYNIPVRGKHAVIVGASNIVGRPMTLEMLLAGATTTTCHRFTQDLEHHIRQADILVVAVGKPHFIPGDWIKEGATVIDVGINRLDSGKLAGDVEYDVAREKAKYITPVPGGVGPMTVATLIENTLLACEQYHSD
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CDIN1_HUMAN
Sequence: MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVVKNGAAPVLLDLANEVDYAPSLMARLILERFLQEHEETPPSKSIINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRAKGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNRFGPGLVIYWYGFIQELDCNRERGILLKACFPTNIVTLCHSIA
What is the function of this protein?
Plays a role in erythroid cell differentiation.
What are the official names of this protein?
CDAN1-interacting nuclease 1, Protein HH114.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly nuclear.
Protein: RF1_LIMF3
Sequence: MEEIFDKLQAVADRYDELNELISDPEVIADSQRFMKLSKEEGSLRETVEKYNEYKEVTQTIKDDTEMLREESDPDLVEMTKEELNEAKERQAQLQDELEVLLIPKDPNDDKNIIMEIRGAAGGDEASLFAADLYNMYVRYAEKQGWNVEVVDRNETEVGGFKEIALIITGDQVYSKLKFENGAHRVQRIPATESAGRVHTSTATVGVMPEAEDVDVDLDPKDIRVDVYRSSGAGGQHINKTSSAVRMTHLPTGIVVAMQDERSQQQNRAKAMQILKARVYDYYQQQEQSEYDAQRKNAIGTGDRSERIRTYNYPQNRVTDHRIGLTLNKLDKIMAGDLEEIIESLIIADQAQKLEQLRNE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_MYCBT
Sequence: MRPYEIMVILDPTLDERTVAPSLETFLNVVRKDGGKVEKVDIWGKRRLAYEIAKHAEGIYVVIDVKAAPATVSELDRQLSLNESVLRTKVMRTDKH
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PAAT_MOUSE
Sequence: METAIEDAGLDRGPTLTSSWDAACGALTQSLFLTRTGPRAQDLDFEQLLEPPAPSQDPVSLKSSLSPRDENPCFIYLNCGPNGGEEILSVGVLSSARNMEVYLGEEYCGTSRGKTACTVLDDSEHEKILLYKKYLKLDSPTHACKIKLLSFGEKQCVLVSKVVVHLRPRSADPSPRSAALGSRIDLDNIQTIMESMGSRLSPGAQQLMSMIRFQQQNRLPIGDQLQSVLGSAGHKHLMALQSSPSPAVLDKASSTPFPFRTGLTPSAITENLKALIDKSAQPSGEGNTTNHDEGHLMPQNHSLESDLKNAVSSFLPKKASGSSSVPSSELLPFLQNLCSQVNHLRVGHNARWQENISKPREGMVGVPMEEQPVCSYLEKILSKNMELMEKKLMDHIDERIYQLQEHIDAKMALLVDLLRGPNSPPPGMPLRHYDSRERLSNGER
What is the function of this protein?
ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10.  Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival.
What are the official names of this protein?
ATPase PAAT, Protein associated with ABC transporters, PAAT.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: SBK3_HUMAN
Sequence: MERRASETPEDGDPEEDTATALQRLVELTTSRVTPVRSLRDQYHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCVSAHPGLLQTLAGPLQTPRYFAFAQEYAPCGDLSGMLQERGLPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVFDPVCSRVALGDLGLTRPEGSPTPAPPVPLPTAPPELCLLLPPDTLPLRPAVDSWGLGVLLFCAATACFPWDVALAPNPEFEAFAGWVTTKPQPPQPPPPWDQFAPPALALLQGLLDLDPETRSPPLAVLDFLGDDWGLQGNREGPGVLGSAVSYEDREEGGSSLEEWTDEGDDSKSGGRTGTDGGAP
What are the official names of this protein?
Uncharacterized serine/threonine-protein kinase SBK3, SH3-binding domain kinase family member 3, Sugen kinase 110.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
Protein: NEPN_MOUSE
Sequence: MHPLWAFLLGLSLTNGLSANCPGRCSCDSMQSVQCYRLMELPSGIPSTTKRLYISHSRIQHLQLSNFTGLLALEDFILLASGTESIENDTFKTLSTLKTLELWKNKLRQVPSALPANLEVLKLNDNAICALRGSEFEGLKNLKVLELKNNLISSLSPSMLSPLASLQSLMVDGNNIESVVGPLSLPHLKYMSMENNQLHLIPGNVFTSLQNLQFLSFSGNFLTKIPINLPKSLLSLKMERNQLKVVRFRDMKHLENLSHLYLSENFLSSIDGAQQLTNLTTLEVSQNQLQMLPPRLPSRLQKLDCSSNFIQRVTAPEFQDLRDLKHLFLDNNVVSLFEAGALQRCSQLSNLALEQNLLLSIPLRLPKTLARLDLKGNAIQDMAERELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGNPWNCTCSLLRAREVLKAKGTDVKGGQCAAPAERQGESWMSSKKILRQCEHHLQQSEKSKETKKKPKPEDSSSIRLNMDDDDDDYEID
What is the function of this protein?
May inhibit TGF-beta signaling.
What are the official names of this protein?
Nephrocan.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MLC1_DROSU
Sequence: YSQVKKEKEQGCYEDFIECLKLYDKEENGTMMLAELQHALLALGESLDDEQVETLFADCMDPEDDEGFIPYSQFIQRLMSDPVVFD
What are the official names of this protein?
Myosin light chain alkali.
Protein: ISPF_BURP1
Sequence: MDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFSDTDPRFKGADSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALVVREAAA
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: EF1B_SULIY
Sequence: MTDVLVVLKVFPDSDEVNLDNLYTDISNKLPKEYRIIRKETEPIAFGLNALILYVQMPEQTEGGTDNLEEVVNNIQGVSHAEVVGITRLGF
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: Y418_LACAC
Sequence: MSSLDKTMHFDFNQNKGKNVYDTLQDVYNALEEKGYNPINQIVGYLLSGDPAYIPRHNDARNLILKHERDEIIEELVKSYLGKNK
What are the official names of this protein?
UPF0297 protein LBA0418.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: UD3A2_HUMAN
Sequence: MAGQRVLLLVGFLLPGVLLSEAAKILTISTVGGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFMPDFKKEEKSYQVISWLAPEDHQREFKKSFDFFLEETLGGRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNENFDMVIVETFDYCPFLIAEKLGKPFVAILSTSFGSLEFGLPIPLSYVPVFRSLLTDHMDFWGRVKNFLMFFSFCRRQQHMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGGLMEKPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPEIFKEMNNAFAHLPQGVIWKCQCSHWPKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENMVRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHVLQTGGATHLKPYVFQQPWHEQYLLDVFVFLLGLTLGTLWLCGKLLGMAVWWLRGARKVKET
What is the function of this protein?
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion.  They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
What are the official names of this protein?
UDP-glucuronosyltransferase 3A2, UDPGT 3A2.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MT3_RABIT
Sequence: MDPETCPCPTGGSCTCEDSCKCQGCKCTSCKKSCCSCCPAECEKCAKDCVCKGGEGAEAEKCSCCQ
What is the function of this protein?
Binds heavy metals.  Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity).
What are the official names of this protein?
Metallothionein-3, MT-3, Growth inhibitory factor, GIF, Metallothionein-III, MT-III.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: PHT19_ARATH
Sequence: MPELSLLSALDAARIQWYHFKAIIVAGMGLFTDAYDLFCIAPIMKMISQIYYHKDSIGTALLSTSYAIALLGTALGQLIFGYLGDRVGRRKVYGLSLLIMVFSSFGCGFSVCTTRRSCVMVSLGFFRFVLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILMSSAVTMVVCLAFKNAGEGSSEKTNVAGLETLAPPESDIAWRLILMIGALPAALTFYWRMLMPETARYTALVENNVVQAAKDMQRVMSVSMISQITEDSSSELEQPPSSSSYKLFSRRFLSLHGRDLFAASANWFLVDVVFYTSNLLLSQIFNFSNKPLNSTNVYDSAFEVAKLAAIVAACSTIPGYWFTVYFIDKIGRVKIQMMGFFLMAVVYLVAGIPYSWYWSKHEKTNKGFMVLYGLIFFFSNFGPNTTTFIIPAELFPARFRSTCHGISGAAGKFGAIVGTVGFLWATRHHEEDGFPDVKRVRIAFLILGGVCIAGMIVTYLFTRETMGRSLEENEDEIVSTSAGSSPANELLRRQY
What is the function of this protein?
High-affinity transporter for external inorganic phosphate.
What are the official names of this protein?
Probable inorganic phosphate transporter 1-9, AtPht1;9, H(+)/Pi cotransporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. phosphate:H(+) symporter (TC 2.A.1.9) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS4_PROMM
Sequence: MSRYRGPRLRITRRLGDLPGLTRKAAKRSHPPGQHGQARRKRSEYAIRLEEKQKLRFNYGISERQLVRYVKKARAQDGSTGTNLLKLLENRLDNVCFRLGFGPTVPGARQLVNHGHVTVNGRVLDIASYQCKAGDVVAIRERKGSKKLAEANLEFPGLANVPPHIELDKAKMSAKIISKCEREWVALEINELLVVEYYSRKV
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: E41L1_RAT
Sequence: MTTETGPDSEVKKAQEETPQQPEAAAAVTTPVTPAGHSHPETNSNEKHLTQQDTRPAEQSLDMEEKDYCEADGLSERTTPSKAQKSPQKIAKKFKSATCRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDHDTEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKREDDAESGGRRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKASERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDAVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGGAFEDFSRSLPELDRDKSDSETEGLVFARDLKGPSSQEDESGGIEDSPDRGACSTPELPQFESVKAETMTVSSLAIRKKIEPEAMLQSRVSTADSTQVDGGAPAAKDFMTTPPCITTETISTTMENSLKSGKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES
What is the function of this protein?
May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
What are the official names of this protein?
Band 4.1-like protein 1, Erythrocyte membrane protein band 4.1-like 1, Neuronal protein 4.1, 4.1N.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MRAY_WOLSU
Sequence: MMYYLYSHAGINIFQYITFRAGAAFFIAFFLALLFMPRFIQWARNQKAAQPISEFAPQGHRGKANTPTMGGLVFIGATLLASLLCAKLNNLYVLAGLAVILLFGLIGLRDDAVKVLNHSNAGLSSRVKMLYLVLAGASVSAALFYFGMEDDLYIPFNKNPLLSMGIVAILFWTLVMVATSNAVNITDGLDGLATVPSVYALVSLSVFVYIAGHAGLSSYLLWPKITDSGEAVIVSAALVGALIGFLWFNCHPAQLFMGDSGSLSIGGFIAYMAIISKNEFLLFLIGSIFVIETVSVILQIGSYKTRGKRIFLMAPIHHHFEVKGWAETKIIVRFWIIALMSNIIALLTLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: THIO_MYCGE
Sequence: MVTEIRSLKQLEEIFSAKKNVIVDFWAAWCGPCKLTSPEFQKAADEFSDAQFVKVNVDDHTDIAAAYNITSLPTIVVFENGVEKKRAIGFMPKTKIIDLFNN
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: RL3_CORK4
Sequence: MSENQIKGILGTKLGMTQVFDEDNRVVPVTVVEAGPCVVTQIRTEEKDGYSAIQIAYGDIDPRKVNKPQSGHFAKAGVTPRRYVTEIRMDDVLSDYEVGQDVTVELFGDVKFVDVTGTTRGHGFAGAMKRHGFAGQGAAHGNQAAHRRVGGIGACATPGRVFKGTRMAGRMGNNRVTTQNLKLFKVDADSNLLLIKGAVPGIRGGLVTVKTAVKGGAHA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: REP_PICV
Sequence: MAPCKPGSNPPKGRVSAAEGGARREATRRPPREAAAKRWCFTLNNPTEEEIKSLETWLVSDFHYAIVGKEVGEQGTPHLQGFVHLKQKKRLPQLKQLFKRAHWEKARGSDEDNEKYCSKEGNVLLTLGIPAKGNRSDLSEAVAAVKAGRAMTEVARDFSEIYVKYGRGLRDLKLLIGQQPRDFKTEVIVITGPPGCGKSRWAADYPGSKFYKMKGEWWDGYDHQEVVIIDDFYGWLPFCELLRVTDRYPHKVPVKGAFVEFTSRVIIVTSNSPPDAWYSEERCCVQALFRRINKWLVWNHDKFEDAPDCMKKYPINY
What is the function of this protein?
Essential for the replication of viral ssDNA.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep and/or Rep' binds a specific hairpin at the genome origin of replication.  Introduces an endonucleolytic nick within the conserved sequence 5'-AGTATTAC-3' in the intergenic region of the genome, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities.  ATPase activity is probably carried by the isoform Rep (By similarity).
What are the official names of this protein?
Replication-associated protein, ATP-dependent helicase Rep, RepP.
What is the protein family that this protein belongs to?
Belongs to the nanoviruses/circoviruses replication-associated protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ACPS_CLAM3
Sequence: MIRGIGVDVVDVARFARSAERTPGLVPRLFAPAERSLPARSLAARFAAKEALIKALGGPGGISWQDMEVVRDEHGDPSFRVAGVVAQVAAARGVTRIHLSMSHDAGLATAFVVTEGDAP
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF1_COXBU
Sequence: MFKILQYPDPRLKTAAQRVEKFDDALQKMIDEMFETHYAATNCAALAATQLDMENPKHITVIDFSPNKDQPLCLVNAEIIERSGEHTEEEGCMSVGGGTFEKVTRAAKIKVRARDRYGKPVEFEADGFMAKCIQHELDHLNGIIFLDRLSTLKRGRIDKRLGKLRRQGKV
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 1, PDF 1, Polypeptide deformylase 1.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: CP2C5_RABIT
Sequence: MDPVVVLVLGLCCLLLLSIWKQNSGRGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGKRSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLMESLNENVRILSSPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVNNPRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIPI
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 2C5, CYPIIC5, Cytochrome P450 1, Cytochrome P450IIC5, Progesterone 21-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Microsome membrane.
Protein: GPMB_ECOSE
Sequence: MLQVYLVRHGETQWNAERRIQGQSDSPLTAKGEQQAMQVATRAKELGITHIISSDLGRTRRTAEIIAQACGCDIIFDSRLRELNMGVLEKRHIDSLTEEEENWRRQLVNGTVDGRIPEGESMQELSDRVNAALESCRDLPQGSRPLLVSHGIALGCLVSTILGLPAWAERRLRLRNCSISRVDYQESLWLASGWVVETAGDISHLDAPALDELQR
What are the official names of this protein?
Probable phosphoglycerate mutase GpmB, PGAM, Phosphoglyceromutase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. GpmB subfamily.