PharMolix/UniProtQA huggingface dataset:
Protein: VP5_BTV10
Sequence: MGKIIKSLSRFGKKVGNALTSNTAKKIYSTIGKAAERFAESEIGAATIDGLVQGSVHSIITGESYGESVKQAVLLNVLGTGEELPDPLSPGERGMQTKIKELEDEQRNELVRLKYNKEITEKFGKELGEVYDFMNGEAKEVEAVEEQYTMLCKAVDSYEKILKEEDSKMAILARALQREAAERSEDEIKMVKEYRQKIDALKSAIEIERDGMQEEAIQEIAGMTADVLEAASEEVPLIGAGMATAVATGRAIEGAYKLKKVINALSGIDLSHMRSPKIEPTIIATTLEHRFKDIPDEQLAISVLNKKTAVADNCNEIAHIKQEILPKFKQIMNEEKEIEGIEDKVIHPRVMMRFKIPRTQQPQIHIYAAPWDSDDVFFFHCVSYHHRNESFFLGFDLGIDVVHFEDLTSHWHALGMAQEASGRTLTEAYREFLNLSISSTFSSAIHARRMIRSRAVHPIFLGSMHYDITYEALKNNAQRIVYDDELQMHILRGPLHFQRRAILGALKFGVKILGDKIDVPLFLRNA
What is the function of this protein?
VP5 protein is one of the two proteins (with VP2) which constitute the virus particle outer capsid.  Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm.  Permeabilization activity is probably negatively regulated by VP2 and is triggered by endosomal degradation of VP2 and exposure to low pH.
What are the official names of this protein?
Outer capsid protein VP5.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP5 family.
What are the subcellular locations of this protein?
Virion.
Protein: METXA_METST
Sequence: MTYKKSLGNVSTKYYKMKEDLQLDTGNILETPTIAYETYGKLNNEKSNVILVCHALTGDAHAAGWHDGDKKPGWWNIIIGPGKPLDTNRYFIICSNVLGSCKGTTGPCDINPKTNKPYGLDFPIITINDMVKAQKKLLDYLDINHLYAVVGGSMGGMQVLQWTITYPDMVRNAIMIASGAYSTPQQIAFNAVQRRSIIEDPNWKGGKYYEEGVSPEQGLSVARMIAHITYLSNESMYEKFGRKLQDKNKFSYDFSTEFQVESYLEHQGSTFTKKFDANSYLYLTKALDYFEVRKNTSLEEALKPVKSRILIMSITSDWLYTHEHMEEIVMALRANNVEVSYSRLNSEYGHDAFLIENGQMNYIISNFLSKARVKDVMSHTTLTLDYTADIKEAAELMMNCNKTHIPIVDDGKEIVGIITAWDLSKAIATDANSIDDIMTKNVLTCTEYDSLHKVIRKMKEHNISGLPVIDKNHKVIGSITTAHISNLYEK
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_MORPR
Sequence: MKMTQTVKKVVVAYSGGLDTSVILPWLQENYDNCEIVAFVADVGQGAEELEGIEAKALASGASECYVVDLKDELVENYIYPTLKTGAVYEGTYLLGTSMARPIIAKAQVEIARKVGADALCHGCTGKGNDQIRFESCFAALAPELTVIAPWRIWDLTSRESLLEYLAERDIPTAASATKIYSRDANAWHISHEGGELEDPWNQPSKQVWTMTVDPIDAPNEPEFLTISVVKGEITAVNGEAMSPYNTLMYLNEKAAAHGVGRVDIVENRLVGMKSRGCYETPGGTVMVEALRGIEELVLDKTTRKWKQTVAAEFSHLVYDGRWFTPLCASLLAAAGTLAEEMNGEVIVKMYKGSVQAIQKKSPNSLYSEEFATFGDDNVYDQSHAEGFIRLYSLSSRIKALASK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_CAUSK
Sequence: MLLAIEQGNTNTMFAIHDGNEWIAQWRAATESTRTADEYVVWLSQLLSMQGLGFRAIDACIISSVVPQSIFNLRNLSRRYFNVEPLVIGENAKLGVDVRIDKPSEAGADRLVNAVGAHMVYPGPLIVIDSGTATTFDIVAADGAFEGGIIAPGINLSMQALHEAAAKLPRIAIQRPANGRIVGTDTVSAMQSGVFWGYIALIEGLVARIKAERAQPMTVVATGGVASLFEGATDSIDHFDSDLTIRGLLEIHRRNTHLETQ
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMBC1_LUMRU
Sequence: MSLCISDYLYLTLTFSKYERQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIKWNEEGLPIYEIPGEGGHAEPAAA
What is the function of this protein?
Displays antimicrobial activity against the Gram-positive bacteria B. subtilis ATCC 62037, S. aureus ATCC 15752 and S. mutans ATCC 25175, the Gram-negative bacteria E. coli ATCC 27325, P. putida ATCC 17426 and Serratia sp.  ATCC 21074, and the fungi C. albicans ATCC 10231, C. neoformans ATCC 34881 and S. cerevisiae ATCC 44774.  Does not possess hemolytic activity.
What are the official names of this protein?
Antimicrobial peptide lumbricin-1.
Protein: PLSY1_OCEIH
Sequence: MYYVIASLLGYIFGCIHGSQIVGKLKGINIKDGGVKNAGASNTTILLGWKYGIVVALIDIFKATAAIFLLLILLQGNAIPTQEQHIYIYLTALFVIIGHNYPITMQFSGGKGTASLVGALIAIDWRIALIGIGVLILFTIATDYLAVGVLSMYISFLITTYYIFGLAPFFIVVGLSVLSIYKHIENYKRIIGKEETKLSSMFGKKAS
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 1, Acyl-PO4 G3P acyltransferase 1, Acyl-phosphate--glycerol-3-phosphate acyltransferase 1, G3P acyltransferase 1, GPAT 1, Lysophosphatidic acid synthase 1, LPA synthase 1.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DUS18_RAT
Sequence: MTSPWSACPVQFPQPSISGLSQITKSLFISNGAAANDKLLLSSNQITTVINVSVEVANTFYEDIQYVQVPVVDAPIARLSDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHVMSLLDAHAWTKSRRPIIRPNSGFWEQLIHYEFQLFGKNTMQMVNSPMGLIPDIYEKETRMMIPLSTPDGAFHKGKEKALL
What is the function of this protein?
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.  In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
What are the official names of this protein?
Dual specificity protein phosphatase 18.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment.
Protein: RLMM_YERE8
Sequence: MNNKIALYCRSGFEKECAAEITTKAAQLEIFGFARVKENSGYVLFECYQLEDADRLIREVPFRELIFARQMMVVGELLKDLPPEDRVSPIVGMLTGVVEKAGELRVEVADTNESKELLKFCRKLTVPLRNAMREQKILSARENPHRPVVHVFFIASGCCYVGYSYSNNNSPFYMGIPRLKFPSDAPSRSTLKLEEAFHVFIPADEWEERLASGMHAVDLGACPGGWTYQLVQRSMMVQAIDNGLMAQSLMDTGQVTHHRVDGFKYEPTRSNIYWLVCDMVEKPAKVTQLIIKWLVNGWCREAIFNLKLPMKKRFEVVSENLEMIDEQLKENGINAHIQAKQLYHDREEVTVHVRRIWSGVPGRRDERF
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBB_VIBVY
Sequence: MNLFASLNQFSKNRISWLLLLLFVVFFEGAALFFQHVMMLSPCVMCIYERVAMLGVGGAALFGLIAPNNPLVRWLGLAAWGASAYKGLALSLQHVDYQFNPSPFATCDLFVTFPDWAPLNQWAPWMFEAYGDCSKIVWQFMTLSMPQWLVIIFAGNLVALAFIVIAQFFKSK
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FLGI_RHOPT
Sequence: MPRVSTHLVKLAAAALCALLLSAVAASATSRIKDLANIEGIRQNQLIGYGLVVGLNGTGDTLNNIPFTKQSLQAMLERMGVNIRGATIRTGNVAAVMVTGNLPPFATQGTRMDVTVSALGDAKNLQGGTLLVTPLLGADGNVYAVAQGSLAIGGFQAEGEAAKITRGVPTVGRIANGAIIEREIEFALNRLPNVRLALRNADFTTAKRIAAAVNDYLGTKCAEPLDPSTVQLSIPGEFKGNAVALLTEIEQLQVEPDQAAKIVIDERSGIIVMGRDVRVATVAVAQGNLTVSISESPQVSQPNPLGGGRTVVTPNSRIGVTEDGKKLAVVKDGVSLQQLVDGLNSLGIGPRDLIGILQAIKAAGAIEADIEVM
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: ARGD1_BRADU
Sequence: MIVMTNSAAPHLLPVFARSDLGFERGEGCWLIATNGDRYLDFTSGVAVNALGHAHPALVKALQEQATKLWHMSNLFQSPDGEKLATRLCNESFADFVFFCNSGAEALEGVIKLVRHHHFSKGHPERYRIITFEGAFHGRTLATLAATGSAKYLEGFGPPMDGFDQVPHGDIEAVKKAIGPQTAGILIEPIQGEGGVRSATPAFLKALRQLCDEKGLLLAFDEVQTGMGRTGDLFAHRRTGVTPDVMSLAKALGGGFPIGAILATADAAAGMGPGSHGSTFGGNPLAIAAANAVLDVMLKPGFFDHVQKMSLLLKQKLASVIDRHGDVVSEVRGEGLLIGIKAVVPSGDLVAALRNEKLLTVGAGDNVVRFLPPLIVTEAEIEDSVGRLERACAAISSSQTKRAAS
What are the official names of this protein?
Acetylornithine aminotransferase 1, ACOAT 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_SHEB8
Sequence: MITSAHIDDIRTQVRAWRAKGETVAFVPTMGNLHQGHITLVKEAASKCDHVVASIFVNPMQFGQNEDLDAYPRTLAADSEALTAAGAELLFTPTPTVMYPKGLEQQTYVEVPGISNVLCGASRPGHFRGVATIVCKLFNIVQPDVALFGNKDYQQLLVIKTMVEDLSLPIEIIGVDTIREDSGLAMSSRNGYLTAAEKAAAPALKQAIDAMAAGIKQGESFEQMTEQAKACLVAAGFTPDYLEIRHAHTLEQAQNQDHALVILAAAYIGKARLIDNLRFDR
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_BAUCH
Sequence: MKVRTSVKTLCRNCKIVKRHGIIRVICSSDPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: HIS1_BACC3
Sequence: MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTDISFILVKAVDVATYVEHGVADIGVVGKDILMENEKDIYEMLDLGVGVCKFCVASIPTYNPKSYRKKCIATKYPHITSNYFHNKGEDVEIIKIEGSVEIAPILGLADAIVDIVETGKTLQENGLIVFEEMYSISARMIVNKAALKTKKDEIFSIINMMEQEILSGK
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGLB_CITFR
Sequence: MNKKVLTLSAVMASMLFGAAAHAADTRIGVTIYKYDDNFMSVVRKAIEKDAKAAPDVQLLMNDSQNDQSKQNDQIDVLLAKGVKALAINLVDPAAAGTVIEKARGQNVPIVFFNKEPSRKALDSYDKAYYVGTDSKESGIIQGDLIAKHWAANPNWDLNKDGKIQFVLLKGEPGHPDAEARTTYVIKELNDKGIKTEQLQLDTAMWDTAQAKDKMDAWMSGPNANKIEVVIANNDAMAMGAVEALKAHNKTSVPVFGVDALPEALALVKSGAMAGTVLNDANNQAKATFDLAKNLADGKGAADGTNWKIENKIVRVPYVGVDKDNLAEFTNK
What is the function of this protein?
Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import (By similarity).  In addition, binds D-galactose and D-glucose and plays a role in the chemotaxis towards these two sugars by interacting with the Trg chemoreceptor (By similarity).
What are the official names of this protein?
D-galactose/methyl-galactoside binding periplasmic protein MglB, D-galactose-binding periplasmic protein, GBP, D-galactose/D-glucose-binding protein, GGBP.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 2 family.
Protein: RS5_PHEZH
Sequence: MARRNEERGDRRNREEERDSEIVEKLVHINRVAATVKGGRRFSFAALMVVGDQKGRVGFGHGKAREVPEAIRKATEEAKKSMIRVPLRESRTLHHDGAGRWGAGKVMVRAAPPGTGVIAGGPMRAVLETLGVQDVVGKSVGSSNPYNMVRATFEALKAQSSPRQVAAKRGKKVSDVIGRRADGASAAQPAADAEG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: PYREL_HALLT
Sequence: MKNVDDLIDSAAELAEHGLSKGEIADELNVSRETASWLVERAGGNHTDTETAATTSTADIHVDWSALGRDSTRLRYAASAMADLLAKQGEEVDLTVGIEKAGAPLATAVANQLDTDLGTYAPAKHQWDEGDIDEQGGGFSRNFAAIRNRDCYVVDDIITSGTTMRESIDAIREQGGEPIACVVLVDKRGYDEIDGVPVYSLVDVVRVDREE
What are the official names of this protein?
PyrE-like protein.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: HBB_OSPRU
Sequence: VHLTAEEKNAITSLWGKVAIEQTGGEALGRLLIVYPWTSRFFDHFGDLSNAKAVMGNPKVLAHGAKVLVAFGDAIKNLDNLKGTFAKLSELHCDKLHVDPENFKLLGNIIVICLAEHFGKEFTIDTQVAWQKLVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: LEUC_SALTO
Sequence: MVGVTPEPRTLAEKVWASHVVRSADGEPDLLFIDLHLLHEVTSPQAFDGLRLAGRRVRRTDLTIATEDHNTPTGYADPSYQSRRGDLLTITDPTSRTQIETLRRNCAEFGVRLHPLGDENQGIVHVIGPQLGLTQPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLPQARPRTMAVNVVGDLAPGVTAKDLVLALIAQVGTGGGRGHVVEYRGEAIRKLSMEGRMTIANMSIEWGAKAGLIAPDDTTFGYLRGRPNAPAGADWEAAVAYWRTLPTDAGATFDSEVTLDASQITPFVTWGTNPGQGASLDASVPNPEEFATEPERAAARRALEYMDLAVGTPLRELTVDVVFVGSCTNGRIEDLRAAADVLRGRRVAPGVRMLVVPGSAAVRENAEAEGLDKVFTEAGAEWRFAGCSMCLGMNPDTLRPGQRAASTSNRNFEGRQGRGGRTHLVSPPVAAATAVTGRLAAPADL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: AQP11_RAT
Sequence: MSALLGLPPEVQDTCISLGLMLLVVLFMGLARVIARQQLHRPMVHAFVLEFLATFQLCYCTHELQLLSEQDSGHPTWTLTLIYFFSLVHGLTLVGTASNPCGVMMQMILGGMSPEMGAVRLMAQLVSALCSRYCISALWSLSLTKYHFDERILACRNPINTDISKAIIIEAICSFIFHSALLHFQEVRTKLRIHVLAALITFLAYAGGSLTGALFNPALALSLHFPCFDESFYKFFVVYWVAPSLGVLLMILMFSFFLPWLHNNQLSNKKE
What is the function of this protein?
Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain.  In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (By similarity).  Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER.  Plays a role in the proximal tubule function by regulating its endosomal acidification.  May play a role in postnatal kidney development (By similarity).
What are the official names of this protein?
Aquaporin-11, AQP-11.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes mainly to the periphery of lipid droplets. it accumulates partly in mitochondrial-associated endoplasmic reticulum membranes.
Protein: FTHS2_STRP8
Sequence: MVLSDIEIANSVTMEPISKVANQLGIDEEALCLYGKYKAKIDARQLVALKDKPDGKLILVTAISPTPAGEGKTTTSVGLVDALSAIGKKAVIALREPSLGPVFGVKGGAAGGGHAQVVPMEDINLHFTGDFHAIGVANNLLAALIDNHIHHGNSLGIDSRRITWKRVVDMNDRQLRHIVDGLQGKVNGVPREDGYDITVASEIMAILCLSENISDLKARLEKIIIGYNYQGEPVTAKDLKAGGALAALLKDAIHPNLVQTLEHTPALIHGGPFANIAHGCNSVLATKLALKYGDYAVTEAGFGADLGAEKFIDIKCRMSGLRPAAVVLVATIRALKMHGGVPKADLATENVQAVVDGLPNLDKHLANIQDVYGLPVVVAINKFPLDTDAELQAVYDACDKRGVDVVISDVWANGGAGGRELAEKVVALAEQDNQFCFVYEEDDSIETKLTKIVTKVYGGKGIRLTPAAKRELADLERLSFGNYPICMAKTQYSFSDDAKKLGAPTDFTVTISNLKVSAGAGFIVALTGAIMTMPGLPKVPASETIDIDEEGNITGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase 2, Formyltetrahydrofolate synthetase 2, FHS 2, FTHFS 2.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: TYW3_BOVIN
Sequence: MDLSAEFKRWKAQCLSKADLSRKGSVDEDVLEIVQLLNGQEQFFTTSSCAGRIILLDRSVNGSEVQKQNCCWLLVTHKACVKDDVIVALQKAKGDAILKFEPLVLHVQCRQLQDAQILHSVAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHQGKLMVTEEYINFLLKIANQKMEENKKRIERFYHCLQHALEKETVSTTSQPKEKVNTSYIRKKKRNPGKARGKRVNEEHDKELENNDHDDPGISDTIFPEDY
What is the function of this protein?
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 3 homolog, tRNA-yW-synthesizing protein 3, tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TYW3 family.
Protein: ACTPC_ACTTE
Sequence: MSRLIIVFIVVTMICSATALPSKKIIDEDEEDEKRSADVAGAVIDGASLSFDILKTVLEALGNVKRKIAVGVDNESGKTWTALNTYFRSGTSDIVLPHKVPHGKALLYNGQKDRGPVATGAVGVLAYLMSDGNTLAVLFSVPYDYNWYSNWWNVRIYKGKRRADQRMYEELYYNLSPFRGDNGWHTRNLGYGLKSRGFMNSSGHAILEIHVSKA
What is the function of this protein?
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and cytolysis.  Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers.
What are the official names of this protein?
DELTA-actitoxin-Ate1a, DELTA-AITX-Ate1a, Cytolysin tenebrosin-C.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Sea anemone subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: AHPD_MYCUA
Sequence: MSIENLKAALPEYAKDLKLNLGSISRTTVLDEEQLWGTLLASAAATRNAQVLAEIGAEAADNLSAQAYQAALGAVSIMGMNNVFYRGRGFLEGQYDDLRAGLRMNIIANPGVDKANFELWSFAVSSVNGCSHCVVAHEHTLREAGVGREAVFEALKAAAIVCGVAQALTAAQTLAAVG
What is the function of this protein?
Antioxidant protein with alkyl hydroperoxidase activity.  Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
What are the official names of this protein?
Alkyl hydroperoxide reductase AhpD, Alkylhydroperoxidase AhpD.
What is the protein family that this protein belongs to?
Belongs to the AhpD family.
Protein: GHRB_SALCH
Sequence: MKPSIILYKTLPDDLLHRLEAHFTVTQVPNLHPETVARHAQAFASAQGLLGASETVNRALLEKMPALRAASTISVGYDNVEVDALTARKIVLMHTPTVLTETVADTVMALMLATARRVVDVAERVKAGEWTESIGPAWFGVDVHHKTLGIVGMGRIGMALAQRAHFGFTMPVLYHARRRHQEAEDRFNARYCDLDTLLQEADFVCVILPLTAETRHLFGATQFARMKSSAIFINAGRGPVVDENALIAALQNGEIYAAGLDVFEQEPLSVDSPLLNMSNVVAVPHIGSATHETRYNMMACAVDNLIDALQGKIEKNCVNPQAAG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_CHLT3
Sequence: MRSDKIKLGFDKAPHRSLLKATGAIQSDEDFQKPFIGIANSYIDIIPGHVHLHDFAKRIKEAVRKAGGIPFEFNTIGVDDGIAMGHIGMRYSLASRELIADAVETVVGAHWLDAMICIPNCDKIVPGMMMAAVRLDIPTIFISGGPMKVGVMADGEKVDLISVFEGVGEYSSGKIDDARLKELENNGCPTCGSCSGMFTANSMNCLAEALGLALPGNGTILAVDPKREALAEAAAKQIMTLVEKDIKPSDLLSRESFLNAFALDLAMGGSTNTILHTLAIANEAGINFDLAELNTLAAKTPYICKVSPATKNVHIEDVDRAGGISAILKELSKLDGVLDLSRPTVTGKTLGENIADAEVKDKAVIHSVEDPYSATGGLAVLFGNLAPQGCVVKTGAVDPKMMQHTGPARIYESQDEAISGILKGDVQAGEVVVIRYEGPKGGPGMPEMLAPTSTIMGQGLGDKVALITDGRFSGGTRGACIGHVSPEAAERGPIAALQNGDKITIDIPNKRIAVDLSDEEIEARLKALPPFEPKIKRGYLARYSQMVTSAGSGAVLKSFD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: GPDA_BRADU
Sequence: MTAFHSVAVIGAGAWGTALAMVAARAGRSVTLWARNAEHATRIASTRDNPRLPGVRLAPDIVVTSELALAARADMLLIATPAQHLRGAVNMLASHIARPTPVVACAKGIEHGTHKFMTEVIAEAALHAQPAILSGPSFADDVARGLPTAVTLAAKEEELASSLVQALGSPTFRPYHSTDVRGVEIGGAAKNVLAIAAGIVVGRNLGASALAALTTRGFSELARLGRACGARPETLSGLSGLGDLLLSCSTAQSRNFALGIALGRGEAAPAGKLAEGAFTAPVLVELAAARNVDMPVSQAVAAILDNKLTIDAAIEGLLTRPFKAEE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_ZYMMO
Sequence: MIFLGLDPGLGTTGWGAITVEGNRLSHIANGQIRTDPSMALARRLALLHDALAAVIASHQPEMAAVEEVLGNSNAQSTLKLGQARGIALFSLAEAGLSVGEYHPNVVKKAVVGTGSADKKQVQAMVSRLLPGVKLAGPDAADALAVAITHAHHHASARGYARRVRAS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.