PharMolix/UniProtQA huggingface dataset:
Protein: GCSPB_SYNWW
Sequence: MSKVIFARSVAGGGGFFLPPCDVAEIEPAAEINPEFLRAEAPLLPELSEVEVVRHYVELSQRAYGVDNGFYPLGSCTMKYNPKINEWAARLPGFANLHPYQPEESVQGALELLYRAEKLCCEIGGMDRFTLQPAAGAHGELTGLMIIKAYHQHRQDLARTKILVPDSAHGTNPATAHVLGFEVVEVKSNEEGLVDLQDLKACMSSEVAGLMLTNPNTLGLFEKEIEEIATVVHADGGLLYYDGANLNGIVGVARPGDMGFDVLHFNLHKTFGTPHGGGGPGSGPVGVKDFLSGFLPHPLVEKKEEGYYLDYDRPLSIGKVRSFYGNFGVIVKAYAYMMALGGPGLREACELAVLNSNYLRHHLQEDYHIPFNRLCKHEFVASGQKQLAENGVSTLDIAKRLMDYGFHPPTVYFPLIVKEALMIEPVETESRERLDEFIAAMREIAREARENPDILHQAPHSTVIKRVDEVRAARQPILRWPGLGAE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: HIS3_VESOH
Sequence: MSALKQIKFDEKGLIPAISQDFKTGEILMFAWMNQESLKLTIKKQQAVYYSRSRQKIWFKGEESGHIQHIKEIFTDCDNDVILLKIEQIGGISCHTGRISCFFQQLDKKNWKIITNMIKNPRDIYG
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H9E01_CYRHA
Sequence: MKSIVFVALFGLALLAVVCSASEDAHKELLKEVVRAMVVDKTDAVQAEERECRWYLGECSQDGDCCKHLQCHSNYEWCIWDGTFSK
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
Omega-theraphotoxin-Hhn1d, Omega-TRTX-Hhn1d, Hainantoxin-IX-5, HNTX-IX-5.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 17 (Hntx-9) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KHSE_THEP1
Sequence: MKVLVPATTTNLGAGFDVFGLALDLFNEVEFSFDTKETTIESTGKYASDLKDHNLFFEVFRFFERKTGYRVPPVRIKQTCNIPVSSGLGSSAAVIVAALHIANEGTGRNLSREDLMKLAVELEGHPDNVVPAFTGGLVVCYQNGSHLDFEKFEIDLSLTFFVPNFSMCTNEMRKILPEKVPFEDAVFNIKNSCQFLAKIAAGKIKEALKYVGDRLHQNYRINGNKKMKEFVEAILSKNPEYWFVSGSGPSVCSNINDFEGIPYLKDVLKLRVNNRGMIVSE
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMM_ECOLI
Sequence: MNKVVLLCRPGFEKECAAEITDKAGQREIFGFARVKENAGYVIYECYQPDDGDKLIRELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELLKFCRKFTVPLRAALRDAGVLANYETPKRPVVHVFFIAPGCCYTGYSYSNNNSPFYMGIPRLKFPADAPSRSTLKLEEAFHVFIPADEWDERLANGMWAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFKFRPTRSNISWMVCDMVEKPAKVAALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYIQAQLDEHGINAQIQARQLYHDREEVTVHVRRIWAAVGGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.  Modifies C2498 in naked 23S rRNA, but not in assembled 50S subunits or ribosomes.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_LACDA
Sequence: MSVKIRMRRMGAKRKPFYRIVVADSRAPRDGRFIEEVGYYNPVSQPKELKLDEDKIFEWLKKGAQPSDTVRSFLSSAGLMAKLHDEKYNK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: FABP6_RABIT
Sequence: MAFTGKFEMESEKNYDEFMKLLGLPSDVVEKSRNIKIVTEIKQDGQDFTWSHHYSGGQIMTNKFTIGKESEIQTFGGKKFKAVVNMEGGKVVANFPNYQHTSEIKGDKLVEVSSIGGVTYERVSKRLA
What is the function of this protein?
Binds to bile acids and is involved in enterohepatic bile acid metabolism.  Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes.  Stimulates gastric acid and pepsinogen secretion (By similarity).
What are the official names of this protein?
Gastrotropin, GT, Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with ileal brush border membranes.
Protein: TCTP_LONON
Sequence: MRIYKDIITGDEMFSDTYKVKLVDEVIYEVTGKLVSRTQGDIQIDGFNPSAEEADEGTDSNVETGVDIVLNHRLVETYAFGDKKSYTLYLKDYMKKLVAKLEEKAPDQVDIFKTNMNKVMKDILARFKELQFFTGESMDCDGMVAMMEYRKVDETEIPIMMFFKHGLEEEKF
What is the function of this protein?
Involved in calcium binding and microtubule stabilization.
What are the official names of this protein?
Translationally-controlled tumor protein homolog, TCTP.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSD_ESCF3
Sequence: MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKYPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_I66A1
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPTEMLASIDLKYFNEPTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPDHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: RS14Z_STRS7
Sequence: MAKKSMIAKNKRPAKYSTQAYTRCEKCGRPHSVYRKFKLCRVCFRELAYKGQIPGVVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: UREF_BURCM
Sequence: MTTTELVALLHLASPALPIGAFSYSQGFEAALDANLIRDADTARDWIAGGLTDVLAHGELPFLAHQLARWHAHDADALARENAWFVASRESAELRRETEQMGWSLAQLCTSLEWGDTARRATLATISPIALPTAFAYAAAAHDASADAVLAAYAFGWVENQTSAALKAVPLGQLAGQRIIVALRGAIDAAVRRALATPPDAVNTFAPQLGILSARHETQYSRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STLP1_ORYSI
Sequence: MKRPLRRPFAVLLFVVLCAAASFPSVLRRSVGPAPVLAPLPPLDPARLNATLLRLAAADPSEAPLRRDVDDLLEGRLPASSARARAWRLRGDRLHLHLRHHQFPVYRRGHHPDHDHDPLLHPLPRQELLLDPSLRRALRSWHRLRRHDPGVLRNLPSLLSLPGRIPSCAVVGNSGILLGASHGALIDSHAAVFRLNNARISGFAANVGAKTNLSFINSNVLHLCARRPNCFCHPYGDGVPILLYICQAAHFLDVASCNASSRSLHAASISVTDPRLDVLCARIVKYYSLRRFVAETGRAAEEWSSTRDAAMFHYSSGMQAIMVAVGVCDRVSVFGFGKAADAKHHYHSNQKAELDLHDYKAEYAFYRDLADRPEVVPFLNDAGIAVPPVVFYH
What is the function of this protein?
Possesses sialyltransferase-like activity in vitro.  Transfers sialic acid to the oligosaccharide Gal-beta-1,3-GalNAc and to glycoproteins such as asialofetuin, alpha-1-acid glycoprotein (NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-) and andasialo-alpha-1-acid glycoprotein.  The transferred sialic acid is linked to galactose of Gal-beta-1,3-GalNAc through alpha-2,6-linkage.
What are the official names of this protein?
Sialyltransferase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: ABAA_ACRCH
Sequence: MSSSSSQSSLYQPRPVLSSQRFSPAPDYIDTRRSFHGDSRLPLRESTGNVQQQHHHQEPSSAHSSFNGGSLVGCYQTPVTLSPSMQSSIPPPAPIVPSQSFDCLRSLQATTSRQHHHVPPPLPQVPTRYHQRGKPRNSINPLYFWPAFRQYRNRQAHKDTQKDKGGVWRRPELEDAFVDSVLLMPHMGRRKFSMGGKLHGRNMLISEYIFVICVALLGSKEIFRIDNSNDSIEQMGRKQVSSHMQVVKKFFEDLRCFHFLFPSEEKKEPGTTNSDDFYEEEEQESFKSNPVLTALAEGRVPDVRPNYEYFSQLLALQSSITVRPKTVEIFVSSADVKIRDEVAYDANDNPLDPASFPHLGKYMNSSGDDKPNVLGKDVLLHEYTRSLDRSTSACVKTVTRRWQRDAPAMYDSLDLPDRDEDCLLLEMCSTVDLHEHAKFPSGSELTGYVEVSVTQPALQGHRWKCVTRLTRPPELQTDEGRPEMYSNESGIHRRGCADTRHEDCGCHLRPRQDIHVPFPAVEWASILSMAVQYPDVEHQRKKEKRSCGKKPDLERSASSSKRKRSEDEGDAAAWTRREPTGSDLICKVAMYQELWSCAPDSTRWTRQAIIFWRFSTTNQWYKYNPVFRPAGTTWRWLTVNDPMSRYHQQRALVYPSAGGNNMPRDAVMSPTPSVSQHLTATMSENFSQAWDSSGSNVTTHTQVHVAGGGGGGGSNMTTLFDSFPSGLATPPPTASLHGSYSASGSFDAGNGVGGCYMPPTCGGGADGPHGGLPAPSQSYFDAAGQTVNTTFGDVKPLLSGSATNPYLPGAAGGGGTGSLDLSGQFAYDDGQQHQHQHQHQQHQQQNHNGGSNGGLPGWDMGPALDSWTAGSSAGGAPAATPTGPDWGPTAPVPRMTEHHPGMWDPVHWSNHGTPGRGGEGSPRQMKRRRTEVLVDGVPVTAGW
What is the function of this protein?
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity).  They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity).  Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (By similarity).
What are the official names of this protein?
Conidiophore development regulator abaA.
What is the protein family that this protein belongs to?
Belongs to the TEC1 family.
What are the subcellular locations of this protein?
Nucleus. Note=localizes to the nuclei of phialides and terminal cells of mature conidia (By similarity).
Protein: UPP1_HUMAN
Sequence: MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA
What is the function of this protein?
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099).  The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Uridine phosphorylase 1, UPase 1, UrdPase 1.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: RL4_METM6
Sequence: MNVKVYNLDGSEKGDIELPAVFETEYRPDLIKRAVISSLTAKLQPKGCDAFAGYRTSAKSIGKGHGKARVRRTAQGAGAFVPQAVGGRRAHPPKVEKILFERINRKERLKALASAIAASANPEIVSARGHKIEGVPSLPLVVNAEFESLAKTKEVLGVFTALKLDADLERAKDGVKIKAGRAKLRGRKYKKPKSVLVVVGDACDAVAASRNLAGVDVITANDLSAIHIAPGTMAGRLTLWTESAIEKLNGRF
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: FMC1_HUMAN
Sequence: MAALGSPSHTFRGLLRELRYLSAATGRPYRDTAAYRYLVKAFRAHRVTSEKLCRAQHELHFQAATYLCLLRSIRKHVALHQEFHGKGERSVEESAGLVGLKLPHQPGGKGWEP
What is the function of this protein?
Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) (PubMed:28719601).
What are the official names of this protein?
Protein FMC1 homolog, ATP synthase assembly factor FMC1, mitochondrial, Formation of mitochondrial complex V assembly factor 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the FMC1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: BPT_SPHAL
Sequence: MSAPFRFPRFFVTSPAPCPYLAGRTERKVFTELSGNNATELNDALGRIGFRRSQSVAYRPSCADCSACVSVRVCASEFAPSNSQKRTLRRNGDLVVTACKPWATEEQYALLRSYLASRHPDGGMADMDEQDFADMVEQTPVDSYMIEYREPVAGGGKGRLVGCCLTDRQGDGLSMIYSFFDAHHPLREGLGTYIIADHVLRAAKAGLPYVYLGYWIEGSARMAYKARFRPLEKLGPDGWSRFEPTPSERIAAMFELA
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_SALPA
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRKRGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMFLVESPEDVWTLNVKNEGKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGRTAFLIDDAADIQEAWVKDAACVGVTAGASAPDILVQNVIARLREFGGGEAVTLEGREENIVFEVPKELRVDVREVE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RK23_CHAGL
Sequence: MIDKVKSPLLTEKSIRLLQKNQYTFQVNSDVNKTEFKKWIEIFFKVKVMSINSCRPPRKKKRIGLISGYTVRYKKIIVTLKSGDSIPLFSI
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UCN2_MOUSE
Sequence: MMTRWALVVFVVLMLDRILFVPGTPIPTFQLLPQNSLETTPSSVTSESSSGTTTGPSASWSNSKASPYLDTRVILSLDVPIGLLRILLEQARYKAARNQAATNAQILAHVGRR
What is the function of this protein?
Suppresses food intake, delays gastric emptying and decreases heat-induced edema.  Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity).
What are the official names of this protein?
Urocortin-2, Urocortin II, Ucn II.
What is the protein family that this protein belongs to?
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Protein: TRPC_PARPJ
Sequence: MSDILDRIIAVKREEVRAAEQSAPLEELRLEASSRDIRDFVGALRAKHTAGLAAVISEVKKASPSKGVLREHFVPAEIARSYEKHGAACLSVLTDVQFFQGSVAYLEEARAACNLPVLRKDFIVDPYQIVEARAMGADAILLIAAALETSQMQDLEALAHSLGLAVLVEVHDHDELMESLTLKTPLIGINNRNLRTFETSIETTIGMLEAIPDDRIVVTESGILSRADVERLRAMDVHTFLVGEAFMRANEPGVELARMFF
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: UEVLD_HUMAN
Sequence: MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYVFKDSSQKDLLNFTGTIPVMYQGNTYNIPIRFWILDSHPFAPPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHPKSVIVGLIKEMIAKFQEELPMYSLSSSDEARQVDLLAYIAKITEGVSDTNSKSWANHENKTVNKITVVGGGELGIACTLAISAKGIADRLVLLDLSEGTKGATMDLEIFNLPNVEISKDLSASAHSKVVIFTVNSLGSSQSYLDVVQSNVDMFRALVPALGHYSQHSVLLVASQPVEIMTYVTWKLSTFPANRVIGIGCNLDSQRLQYIITNVLKAQTSGKEVWVIGEQGEDKVLTWSGQEEVVSHTSQVQLSNRAMELLRVKGQRSWSVGLSVADMVDSIVNNKKKVHSVSALAKGYYDINSEVFLSLPCILGTNGVSEVIKTTLKEDTVTEKLQSSASSIHSLQQQLKL
What is the function of this protein?
Possible negative regulator of polyubiquitination.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 variant 3, UEV-3, EV and lactate/malate dehydrogenase domain-containing protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the LDH/MDH superfamily.
Protein: TOLB_DECAR
Sequence: MNAMSRISRRIFLALALSLAGLAQAQLSIEITGAGANRIPVTIVDFPGDPTAARVVTATVRADLERSGLFKLVDNGTAAFDENAPVNHAEWKGKGADALAAGSIARSTDGRMEARFRLYDTQKGVSLGGAAYVTNNSQLRAAGHRIADFIYEKLTGEKGVFSTRIAYVVKARGQFLLQIADSDGQNAATALSSTEPIISPVWSPDGGRLAYVSFEKKKPVIYVHTLASGQRHIVANFKGSNSAPAWSPDGRKLAVVLSKDGNSQIYSVNADGSGLQRITQSSGIDTEPRYSADGGTIYFTSDRGGSPQVYQVGASGGDAKRVTFEGSYNVSPRPAPDGKSLAFISRREGRFQLAVMDLASRQVQVVSDSNKDESPSFAPNSRMILIATEIGGRGVLSAVSSDGRIKQRLSVAAGDVREPAWGPYYQ
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: AAEX_SALA4
Sequence: MSLFPVIVVFGLSFPPIFFELLLSLAIFWLVRRMLVPTGIYDFVWHPALFNTALYCCLFYLISRLFV
What are the official names of this protein?
Protein AaeX.
What is the protein family that this protein belongs to?
Belongs to the AaeX family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS1_BRASO
Sequence: MSGPLVLAVPSKGRLQENAEAFFGRAGLNLSKPGGARDYRGTISGLDNVEIAYLSASDIASQLARGTVHLGVTGEDLVREEITDADKRVLLIDTLGFGGANVVVAVPQAWIDVRTMADLDDVASGFRAQHNRRMRVATKYINLTRGFFASHGIVDYRIVESAGATEGAPAVGTAELIVDITSTGSTLVANGLKVLDDGVILRSQANLVASRDADWSEGPRESARIILDHIHARARASKYREVRTRFKGCDAAMLTEAHNRFGVVAPFGGPTSSGMLTLHCPPAQIYSLGSFLRAHGAETVSVASLDYVLDRENPLFARLEAFLRS
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_I70A0
Sequence: QDLPGNDNSTATLCLGHHAVPNGTLVKTITNDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDGFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTEVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGQSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQT
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: KYNU_CAEEL
Sequence: MSDAPPQPENEQECMCTQDKVLQFLNKMADESGIKDLTDPALAEFLSDSDALKEIRDLFHYPKAGTLPDADPSLVDPESDSIYLCGNSLGLMPKATGEVMKDHLDKWAKMGVFGHMSGEVPWAHCDEYCLEGVGRLVGAKKEEVSVCNSLTVNIHVLLTSFYKPTETRHKILLESKAFPSDHYAIESQIRLKGRTVQDSMVCLEPREGEETLRTEDILDYIEKNGDEIAIVFFSGIQYYTGQLFDMRAITEAGHRKGCFVGFDLAHAFANVPLHLHWWDVDFACWCSYKYGCTGAGSIGGLFVHERFLNDQRERMLGWWSHKMSSRFVMDNVLDLDEGAAGYRISNPPIHTVAAMLGSLKVFDQVSLENLRSRSCYLTGYLEYLVKTLFGENSEQRTTKLSISIITPEEFHQRGCQLSLKFSSPIDIIYPELVKRGCAVDKRYPNVIRVAPVHLYNNYVDIRRFISVLQEVAHIVESE
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, Abnormal fluorescence under UV illumination, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
What are the subcellular locations of this protein?
Cytoplasm.