PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_STRMU
Sequence: MLFCLLRFCYNSLMTRILDNELMGDEEFAERTLRPQYLQEYIGQDKVKDQLKIFIKAAKQRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPAIEKAGDLVAVLNDLEPGDVLFIDEIHRLPMAVEEVLYSAMEDFYIDIMIGAGETSRSVHLDLPPFTLIGATTRAGMLSNPLRARFGITGHMEYYTDIDLTEIVERTADIFEMTITHQAALELARRSRGTPRIANRLLKRVRDYAQIMGDGLIDDKITDKALTMLDVDHEGLDYVDQKILKTMIEMYHGGPVGLGTLSVNIAEERETVEDMYEPYLIQKGFIIRTRSGRVATAKAYEHLGYRYTE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PLSX_ERYLH
Sequence: MSLPRIALDAMGGDVGVRVMIDGAAEARRRHDRFKFLLVGDETRIKAALDTHPNMRGASEILHCEDVVGGDEKPTQALRRAKTTSMGLTVNAVKQGEAGAAVSAGNTGALMAMSKLALRTMPGIDRPALAGVMPTLEEDDVVMLDLGANTEADARNLVQFAIMGAAYSRILTGREEPRVRLLNIGTEEIKGTDALRDAAAQLQDAAGLAMQFDGFVESDKINRGQVDVVVTDGFSGNIALKAIEGAARFVTDLLRNAFTSSIRSKVGFLVSRPATELLKHHLDPNNHNGAVFLGLNGVVVKSHGSANSVGVANAVAVAASLLENDLTARIASDLAELGERMWDATGGNGNGPAPK
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: CYSG_NEIM0
Sequence: MNYFPIFANLAGRPVLVVGGGSVAARKISLLLDAGAQVRVVANQLNAELSALAAENKILWLAEEFRAEHIRTVFLIIAASSDQALNRRVFQLAESCQKPVNVVDDRDYCSFIFPSIINRNPIQIAVSSSGSAPVLARLLREKLEALLPHSLGDMAEISGRWRDAVKAKLKSVTERRRFWEKQFNGRFAALVKNQQTAQAEQELAKQLEQNYQGGFVSLVGAGPGDAGLLTLKGLQEIQQADVVLYDALVSDGILSLVRRDAERIFVGKRARGDRTPQEDTNALMVRLAREGRRVVRLKGGDPFVFGRGGEELETLARHQIPFSVVPGITAAVGATAYAGIPLTHRDYAQSAVFVTGHRKADAPDIEWQTLARSRQTLVIYMGALKAALIAERLQQHGRSPDTPAAVISQGTLPAQKTATGTLANLAELAETAPNPALIVIGEVVGLHEKLAWFGENGEGENRVGQAYPALGGLNAGQRAA
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: DAPB_LISIN
Sequence: MKVAVSGFKGRMGHEVVKTILREEDLELVAVLDHEPKEKNIREIVEFSSLDVPVYGDLSEMLEEIKPDCVVDFTIPKVGYSNTKTILEHSVRAVVGTTGFTPEQISELKSIAESKKIGALIAPNFAVGAVLMMQFAQKAAKYFPNVEIIELHHDNKLDAPSGTAVKTAEMMAETREFVKQGAADEVELIEGARGGEYEGMRIHSVRLPGLVAHQEVIFGAEGQGLTIRHDSYDRISFMSGVALSVRKTKELETLIYGLENILD
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSXE_ECO57
Sequence: MSEIKDVIVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTISTLRHWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPALSALDGFSIGMGATCAMFVLGSLREIIGNGTLFDGADALLGSWAKVLRVEIFHTDSPFLLAMLPPGAFIGLGLMLAGKYLIDERMKKRRTEAAAERALPNGETGNV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rsx electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYAY_EDWI9
Sequence: MNDSEFHLLADGLMQALEEALDACQSDADIDCETNGGVMTLSFENGSKIVINRQEPLHQIWLATRAGGYHFDYRNGQWRCSRSGVPLPQVLNEACSAQAGIPVTLDL
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: LPW_SALTY
Sequence: MAATFALHGWWRTS
What is the function of this protein?
This protein is involved in control of the biosynthesis of tryptophan.
What are the official names of this protein?
trp operon leader peptide.
Protein: MNMC_PSYIN
Sequence: MSDAKYKLIKHAQIHWSDQLEPFSSLFDDIYFNTEQGIDEANYVFFDGNKLGKRWLDYSAQHFSIAETGFGTGLNFLLTCQKFAEFIKLNPNNPLKKLHFSSFEKYPLTKPDLIIALQQWPQLTAFITPLLAQYPIALKGCHRLVLNEFNITLDLWFGDIADTLPSLHVYDCGLFDCWYLDGFAPSKNPEMWNDDLFQLISQSCKKDATIATFTAASFVRKGLIKAGFEMGKQKGYDKKREMLIGHISTEALAANKLKQHGQYYRPAKSENTAQKKTDVAIIGGGIASACLSLALIRRGYKVTLYCKESSLAFGASGNQQAALYPLLNEQHDALSQFFANAFLYSRNYIKQINQTQPVDYSFSGVLQLYYDPSASKKLDKILQAGLPQELVEQLTEIETDNIAGISIAQKSLHYPLGGWLSPKQLVEAIVRQAKNEGDLSVHLNQELLTFEQSPSDNPALNPAQPINSWDLHFAKHSIQHSLLVLATANNTLNFKQCEAVPLSAARGQVTHIPTNHKINPLQITLCHEGYLTPANNQQHCMGATFKRHDLNQAFSQQEQVDNKDKLEKCIPGKTWTEQIDINHPNAHVGIRCTTRDHFPYVGAIPDYQATKIHYKNAAKEVNPVNAPFHPNLYLLTGLGSRGFCSAPLLAEMLASQINKEPLPFAKEILNAMQINRQWINYLKKGKPLHY
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJHU_ECOLI
Sequence: MDRDQTNSSLFNDDPVLHATWLYYQEGKSQTEVAAIMGVSRVTVVKYLQTARENGLVHINLDVNVFGSIDAALQIRDKFNLQRVIIVPDGEHAGKRDDTKLMRTRLSRAGGMYLNQVIENGDVLGVAWGRTIHQMSKTMTPKSCKNVTVIQMLGSMPSQPDLTIIESSSQIAYKLSGRVASLHVPAVVSSARLAMELQAEPIIRSNFDVLTRCTKAFFVVGNALDENPLIRVGVLNKKEMQTYRDLGAVGVICGRFYDKEGMPVVADVDQRILGISLAQLRQIERKIFLAGGERGYDATLGALLGGYVTDLIVDEGTAEFLLACELPH
What are the official names of this protein?
Uncharacterized transcriptional regulator YjhU.
What is the protein family that this protein belongs to?
Belongs to the SorC transcriptional regulatory family.
Protein: GCSP_SHELP
Sequence: MTTETLTQLEQHELFIRRHIGPDSADQQEMLNFVGAESLEDLTQQIVPESIRLGRDLAVGSACGEAEGLASIRKYADKNKVFKSYIGMGYYGTIVPSVIQRNVFENPGWYTAYTPYQPEIAQGRLEAILNFQQLSMDLTGLDLASASLLDEATAAAEAMALAKRVSKAKKANIFFIADDVFPQTIDVVKTRAECFGFEIVVGPASEAVNYELFGALFQYTNHYGQITDFTELFAALQEKKAVVTVAADIMSLVSLKSPGSMGADVVFGSAQRFGVPMGFGGPHAAFFVTRDQHKRSLPGRIIGVSQDTRGNRALRMAMQTREQHIRREKANSNICTAQVLLANMASFYAVFHGPQGLKIIADRIHRLADIFAAGLKAKGVELVNNTWFDTVSFKVADSAAAQARAIAGEVNLRIDSDGILGVAMAETTTREDVAQLFDIVLGEGHGLDVAAIDADIIANGSNSIPAELVRQDAILEHPTFNRYHSETEMMRYIKRLENKDLALNHSMISLGSCTMKLNAATEMMPVSWPEFGNMHPFCPQDQAQGYAELIEELSNWLVDITGYDAMCMQPNSGASGEYAGLLAIKKYHESRGEGHRNVCLIPQSAHGTNPASAQLAGMKIVVTACDKQGNVDMEDLKAKAAEVAENLSCIMVTYPSTHGVYEETISEICEVIHQHGGQVYLDGANMNAQVGLTSPGSIGADVSHLNLHKTFAIPHGGGGPGMGPIGVKAHLAPFVAGHAVVKHGRESDNNGAVSAAPYGSASILPITWMYIKLLGYQGLRQSTQMALLNANYVMKKLSAHYPVLYTGRNDRVAHECIIDLRPLKEASGVTEMDIAKRLNDYGFHAPTMSFPVAGTLMIEPTESESKAELDRFIEAMVAIRGEIAKVEAGEWPADNNPLHNAPHTMADIMDSEFDSRPYSRETAVFPTAAVKANKFWPTVNRIDDVYGDRNLMCSCAPIDDYK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: TRPC_STAAM
Sequence: MTILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPTVNDLPERDLSQQISDYEKYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLIEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKPNHHYISESGIHDASDVRKILHSGIDGLLIGEALMRCDNLSEFLPQLKMQKVKS
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: GATD_STRR6
Sequence: MVYTSLSSKDGNYPYQLNIAHLYGNLMNTYGDNGNILMLKYVAEKLGAHVTVDIVSLHDDFDENHYDIAFFGGGQDFEQSIIADDLPAKKESIDNYIQNDGVVLAICGGFQLLGQYYVEASGKRIEGLGVMGHYTLNQTNNRFIGDIKIHNEDFDETYYGFENHQGRTFLSDDQKPLGQVVYGNGNNEEKVGEGVHYKNVFGSYFHGPILSRNANLAYRLVTTALKKKYGQDIQLPAYEDILSQEIAEEYSDVKSKADFS
What is the function of this protein?
The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide (PubMed:24044435, PubMed:30093673).  The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia.  The resulting ammonia molecule is channeled to the active site of MurT (PubMed:30093673).
What are the official names of this protein?
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD, Lipid II isoglutaminyl synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. GatD subfamily.
Protein: FOXJ1_MOUSE
Sequence: MAESWLRLCGAGPGEEAGPEGGMEEPDALDDSLTSLQWLQEFSILNAKAPTLPPGGTDPHGYHQVPGLVAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQASQEPSAAPWGGPLTVNREAQQLLQEFEEATGEGGWGTGEGRLGHKRKQPLPKRVAKVLRPPSTLLLTQEEQGELEPLKGNFDWEAIFEAGALGEELSSLEGLELSPPLSPSSHGDVDLTVHGRHINCPATWGPPAEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPIFEAGDATLAADLQDWASVGAFL
What is the function of this protein?
Transcription factor specifically required for the formation of motile cilia (PubMed:9096351, PubMed:9739041, PubMed:10873152, PubMed:14996907, PubMed:22357932, PubMed:27965440).  Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157 (PubMed:27965440).  Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T) (PubMed:9096351).  Activates the transcription of a variety of ciliary proteins in the developing brain and lung (PubMed:28666954, PubMed:27914912).
What are the official names of this protein?
Forkhead box protein J1, Hepatocyte nuclear factor 3 forkhead homolog 4, HFH-4.
What is the protein family that this protein belongs to?
Belongs to the FOXJ1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MRAY_BRASO
Sequence: MFYWLIELTNTFPSLSVFRGVLNVFRYITFRTGGAVVTGALFVFLFGPWIIDHLRLRQGKGQPIRTDGPQSHIISKKGTPTMGGLMILSGLVVSTVLWANPLNPYVWIVLAVTLGFGFVGFYDDYLKVTKQSHSGFAGRARLLIEAAIALVACYALVRLGRDPSSTGLAIPFFKDLVIKFGWMYVIFGAFVIVGAGNAVNLTDGLDGLAIVPVMIASASFGLIAYLAGNAVFSDYLQIHYVAGTGELAVLCGAVLGAGLGFLWFNAPPASIFMGDTGSLALGGMLGSIAVAVKHEIVLAVIGGLFVLEAVSVIVQVASFKLTGKRIFRMAPIHHHFEQLGWTEPQIVIRFWIISVMLALVGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y111_MYCPN
Sequence: MNKNSGKDYESIQGKIKSKAEIEDSVILDQDTFQGKGEEKTKLDELIRWEAEKNDLLKLIDNVGNDEVFTPVETCQRMLDELFPEDHEVWSNPDLKWLNPCDKNGVFFREIALRLDKGLTKIIPDEYARKKHIMTKMLFSIGLTKFTSLMVRRTLYYCIKANKRKTSEDEGCAIANGARFNNEFGNVVTPYKEHYFGKESKSKNCHFCGTNKNSKYVNSMTEEKYAYDFIHLNSDEYENYFKTNFGVMKFDVIIGNPPYQLSNGSGSDGNGAKAIFQDFVLKAIDLEPKYLAMIIPAKWMISAENIFLNLRDKLKKNKDIKEINIFFDSKDCFPKREIKGGICYFIWQNNYQGKTLINTKFSKKGKSTEIDSSKRNLFVSVLNNTEQIIFRKRIWQDIYTKIDSISASEMKNTHTEREQFRS
What are the official names of this protein?
Uncharacterized adenine-specific methylase MPN_111.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: LSRC_YERPE
Sequence: MLKFIQNNREGTALLAILTLFALLGIIDRNYFSLQTFTMIFSSAQILILLAIGATLVMLTRNIDVSVGSITGLCAVTVGMALNAGFGLAASCLFALLVGMVAGFFNGILVTWLRIPAIVATLGTLGLYRGLMLLLTGGKWIEGLPADLKSLSTPILFSISPIGWLTMLLILAMAWLLGKTAFGRSFYATGDNLQGARQLGVRTDSLRIFAFSMNGVMAALAGIVFASQIGFIPNQTGNGLEMKAIAACVLGGISLLGGTGTIIGAILGAFLLTQIDSVLVLLRLPAWWNDFIAGLVLLGVLVFDGRLRCAVERNIRQQKYARFTAQAIISDKKPTVSDNNPAASNKKKAAL
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Autoinducer 2 import system permease protein LsrC, AI-2 import system permease protein LsrC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NTPTH_THEVO
Sequence: MAIKIGITGPVGSIKAEALQKIIGMLQNDGLNVQGVLISKVSDDGKLTGYTIEDILTKKKVQFCDEKFVSRVKIDKLGVDTRLLEEILIPSLQKARESADVIIIDEVGKLENTTKKIHSEIEETLKCGKPLIVTLHKRSRNPVLQEIKSLEGVRVFDITPINKNILPFKVMHVLKGEE
What is the function of this protein?
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP.  May hydrolyze nucleoside diphosphates with lower efficiency.
What are the official names of this protein?
Nucleoside-triphosphatase THEP1, NTPase THEP1, Nucleoside triphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the THEP1 NTPase family.
Protein: DHX37_HUMAN
Sequence: MGKLRRRYNIKGRQQAGPGPSKGPPEPPPVQLELEDKDTLKGVDASNALVLPGKKKKKTKAPPLSKKEKKPLTKKEKKVLQKILEQKEKKSQRAEMLQKLSEVQASEAEMRLFYTTSKLGTGNRMYHTKEKADEVVAPGQEKISSLSGAHRKRRRWPSAEEEEEEEEESESELEEESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVPPPPAAAPPLPRALAKPAVFIPVNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAKPPPVIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPPSRARPQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLDHYSVLPAGEGDEDREAEVDEEEGALDSDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEELLIALGALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYASCTPQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVTYLRQIVTAGLGDHLARRVQSEEMLEDKWRNAYKTPLLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPALLPSYCQFDKPLEEPAPTYCPERGRVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYRSCLLSSPGTMLKTWARLQPRTESLLRALVAEKADCHEALLAAWKKNPKYLLAEYCEWLPQAMHPDIEKAWPPTTVH
What is the function of this protein?
ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis (PubMed:30582406).  Required for the release of the U3 snoRNP from pre-ribosomal particles (PubMed:30582406).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).  Plays a role in early testis development (PubMed:31287541, PubMed:31337883).  Probably also plays a role in brain development (PubMed:31256877).
What are the official names of this protein?
Probable ATP-dependent RNA helicase DHX37, DEAH box protein 37.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Nucleus membrane.
Protein: HIS1_HALH5
Sequence: MSMLTVAMPKGRIFDEAVGLLRKAGYNLPAEFEASRKLIVDVPEENMRFILAKPMDVPTYVEHGVADVGVAGKDVMLEEERDVYEVLDLKISECYLAVAGLPNYEKKHDLNPKVASKYPHLATRYFKEQGEQVEIIKLNGSIELAPLIGLADRIVDIVSTGRTLRENGLVELEKMMTITSRLIVNPVSYRMKDERIDEMVERLLQVVEGDGA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
Protein: NEU2_ONCKE
Sequence: MTGAAVSVCLLYALSVCSACYISNCPIGGKRSIMDAPQRKCMSCGPGEQGRCFGPSICCGKDVGCWMGSPETAHCMEENYLPTPCQVGGRPCGSDTVRCASPGVCCDSEGCSADQSCFAEEEGDNQIGQSEGSNSADVILRLLHLADHTPPHRVHQ
What is the function of this protein?
Isotocin causes contraction of smooth muscles.
What are the official names of this protein?
Isotocin-neurophysin IT 2.
What is the protein family that this protein belongs to?
Belongs to the vasopressin/oxytocin family.
What are the subcellular locations of this protein?
Secreted.
Protein: WAPC_DEMVE
Sequence: MSSGGLLLLLGLLTLWAELTPVSSLDRPKKPGLCPPRPQKPPCVRECKNDWRCPGERKCCRYGCIYECRDPIFVK
What is the function of this protein?
Damages membranes of susceptible bacteria.  Has no hemolytic activity.  Not toxic to mice.  Does not inhibit the proteinases elastase and cathepsin G.
What are the official names of this protein?
Veswaprin-c.
What is the protein family that this protein belongs to?
Belongs to the snake waprin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KHSE_BACP2
Sequence: MSKASMLFSITVPGSTANLGPGFDSVGMALSRYLKLSVFDHDSWLFEAESDVVSGIPPGTDNLIYQTAKKVADHFGKTLPPVYVKVWSDIPLARGLGSSAAAIVAAIELANQLLELNMTDDQKLFFASEVEGHPDNAGASLFGGLLIGLHEEDKTHAVKVKHVDIDVVVVIPFYEVLTKDARDVLPEDFSYKHAVSASAVSNVLVAALMTQNWPLVGEMMNKDLFHQPYRTMLVPELSKVEHVASLKGAYGTALSGAGPTILTLIEKGKGEGLKKQLAQNFPHCEVDLLTVPVEGVVVEHDPVNQVKNVL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABFB_PENCN
Sequence: MIPQLNRNYAWAIALGLVARSSLVSAGPCDIYASGGTPCVAAHGTTRALHDSYTGPLYQVKRGSDGATTDIAPRHAGGVANATHQDTFCAGTTCLITIIYDQSGHGNHLSQAPPGHFIGPDSQGYDNLASAIGAPVTLNGQKAYGVFISPGTGYRNNAAKNTATGDEAEGLYAVLDGTHYNNGCCFDYGNAEVSGDDTGNGHMEAIYFGDLTAYGTGSGSGPWIMADLENGLFSGFNAKNNAEDPSLSYRFISAAVKGGPNKWAIRGGNAASGPLSTFYNGSRPNARGYNPMSKEGAIILGIGGHNSKLTVGSSISLRATTLCCTTRYVAHNGSTVNTQVVSSSSSAALKQQASWRVRTGLANSECFSFESVDTPNSFLMHNNFVLLLKSNDGTKALHEAATFCPQLGLNGKGNSIRSWSYPTRYFRHYDNVLYAASNGGVHKFDNPASFNDDVSWVVSASFA
What is the function of this protein?
Secreted alpha-L-arabinofuranosidase that actively hydrolyzes p-NP-alpha-L-arabinofuranoside and is specific for furanose configuration of the carbohydrate ring.  Exhibits also significant activity against polymeric arabinose-containing substrates such as arabinan and arabinoxylan, a major component of plant hemicellulose.
What are the official names of this protein?
Alpha-L-arabinofuranosidase B, ABF B, Arabinosidase B, Alpha-L-arabinofuranosidase of 60kDa, AF-60.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 54 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MTR_PSEAB
Sequence: MSSSPAQTPSRRPSLLGGSMIIAGTAVGAGMFSLPIAMSGIWFGWSVAVFLLTWFCMLLSGMMILEANLNYPVGSSFSTITRDLLGQGWNVVNGLSIAFVLYILTYAYISGGGSIIGYTLSSGLGVTLPEKLAGLLFALAVALVVWWSTRAVDRITTLMLGGMIITFGLSISGLLGRIQPAILFNSGEPDAVYWPYLLATLPFCLTSFGYHGNVPSLMKYYGKDPQRISRSLWIGTLIALAIYLLWQASTLGTIPREQFKGIIAGGSNVGTLVEYLHRITASDSLNALLTTFSNLAVASSFLGVTLGLFDYLADLCRFDDSHFGRFKTALLTFVPPTIGGLLFPNGFIYAIGFAGLAAAFWAVIVPALMARASRKRFGSPLFRAWGGTPAIVLVLLFGVANAVAHILASLHWLPEYR
What is the function of this protein?
Involved in the transport of tryptophan into the cell.
What are the official names of this protein?
Tryptophan-specific transport protein, Tryptophan permease.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Secreted. Note=Could be present extracellularly due to cell lysis.
Protein: YIFL_SALTY
Sequence: MKNVFKTLAVLLTLFSLTGCGLKGPLYFPPADKNAPPPTKKVDSQTQSTMPDKNDRATGDGPSQVNY
What are the official names of this protein?
Uncharacterized lipoprotein YifL.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: DGK1_SCHPO
Sequence: MSTKLTWSQWSKKHEIPRKALHTSIGFFALLLQGCGYHAAQIIPVIEIGFIPAFTGDVIRFNWPAFSRLYNRVIGPLMRESEKNAWNGVIFYMIGVWIVLKVFPEEIAVMSVLLLSWCDTTASTVGRKWGKYTPKIAKNKSLAGSLGAFVCGVFCCYVYWGLFRTGPDSLAAQSRIPFPWLCLINGFIGAFAEAMDVWGLDDNLVIPVVSACLLYLIM
What is the function of this protein?
CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA).  Controls phosphatidate levels at the nuclear envelope.  Counteracts the activity of PA phosphatase ned1.  May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity).  Involved in pre-tRNA splicing (PubMed:11955632).
What are the official names of this protein?
CTP-dependent diacylglycerol kinase 1, Diglyceride kinase 1, DAG kinase 1.
What is the protein family that this protein belongs to?
Belongs to the DGK1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.