PharMolix/UniProtQA huggingface dataset:
Protein: IOLA_LACCA
Sequence: MDTTKQNVKTLKNFINGKWVDAKTETFENVYNPATGDVLARVPHSTSEDVADAVTAAKEAFKIWQKVSIPKRAKILFKYQQLLVEHQEELGRIVTEENGKSLDEAVAEVGRGIENVEFAAGVPTLMMGDSLSSVATDVEATNYRYPIGVVGGITPFNFPMMVPCWMFPMAVATGNTFILKPSEKTPLTSQRLVELFQEAGLPDGVLNIVNGAVDVVNGILDHPDIKAISFVGSERVGEYVYKRGSDHLKRVQALTGAKNHTIVLADADLDAAVKGIISSSFGSAGERCMATSVLVLQDEIADKFMAKFTQAAKDIKIGNGLDKGVFLGPVIRKENQERTLNYIQTGVKEGAKLVLDGSAEAKKHDGYFVGPTIFEDVKTDMTIWHDEMFAPVLSVIRAKDLPQAVAIANTSELANGACLFTDSAASIRYFRENIDAGMLGINLGVPAPIAVFPFSGWKHSFFGTLHANGKDSVDFYTHKKVVTARYDQRRFK
What is the function of this protein?
Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.
What are the official names of this protein?
Malonate-semialdehyde dehydrogenase, MSA dehydrogenase, Methylmalonate-semialdehyde dehydrogenase, MMSA dehydrogenase, MSDH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. IolA subfamily.
Protein: PDX2_PLABE
Sequence: MEKLTIGVLSLQGNFQSHINHFLQLQNPSLKVIEVRNKTNLRECDGIVIPGGESTTLRKCMSYDNDSLYNALKNYIHVKKKPVWGTCAGCILLSEKVEKNKDDNIENEYGNDFSLGGLDIEITRNYYGSQNDSFICSLDIKSQDPIFKKNIRAPCIRAPFIKKISSDKVVTIATFSHESFGKNIIGAVEQDNCMGTIFHPELMPYTCFHDYFLEKVKKHIKDSREA
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: CYSA_PSEAE
Sequence: MSIEIRNVSKNFNAFKALDDINLDIQSGELVALLGPSGCGKTTLLRIIAGLETPDAGNIVFHGEDVSQHDVRDRNVGFVFQHYALFRHMTVFDNVAFGLRMKPKGERPGESAIKAKVHELLNMVQLDWLADRYPEQLSGGQRQRIALARALAVEPKILLLDEPFGALDAKVRKELRRWLARLHEEINLTSVFVTHDQEEAMEVADRIVVMNKGVIEQIGSPGEVYENPASDFVYHFLGDSNRLQLGNDQHLLFRPHEVSLSRSAVAEHRAAEVRDIRPLGAITRVTLKVDGQDELIEAEVVKDHDSLAGLARGETLYFKPKAFQPVANL
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ALL12_ARAHY
Sequence: MRGRVSPLMLLLGILVLASVSATHAKSSPYQKKTENPCAQRCLQSCQQEPDDLKQKACESRCTKLEYDPRCVYDPRGHTGTTNQRSPPGERTRGRQPGDYDDDRRQPRREEGGRWGPAGPREREREEDWRQPREDWRRPSHQQPRKIRPEGREGEQEWGTPGSHVREETSRNNPFYFPSRRFSTRYGNQNGRIRVLQRFDQRSRQFQNLQNHRIVQIEAKPNTLVLPKHADADNILVIQQGQATVTVANGNNRKSFNLDEGHALRIPSGFISYILNRHDNQNLRVAKISMPVNTPGQFEDFFPASSRDQSSYLQGFSRNTLEAAFNAEFNEIRRVLLEENAGGEQEERGQRRWSTRSSENNEGVIVKVSKEHVEELTKHAKSVSKKGSEEEGDITNPINLREGEPDLSNNFGKLFEVKPDKKNPQLQDLDMMLTCVEIKEGALMLPHFNSKAMVIVVVNKGTGNLELVAVRKEQQQRGRREEEEDEDEEEEGSNREVRRYTARLKEGDVFIMPAAHPVAINASSELHLLGFGINAENNHRIFLAGDKDNVIDQIEKQAKDLAFPGSGEQVEKLIKNQKESHFVSARPQSQSQSPSSPEKESPEKEDQEEENQGGKGPLLSILKAFN
What are the official names of this protein?
Allergen Ara h 1, clone P41B, Allergen Ara h I.
What is the protein family that this protein belongs to?
Belongs to the 7S seed storage protein family.
Protein: FIEF_SHIBS
Sequence: MNQSYGRLVSRAAIAATAMASLLLLIKIFAWWYTGSVSILAALVDSLVDIGASLTNLLVVRYSLQPADDNHSFGHGKAESLAALAQSMFISGSALFLFLTGIQHLISPTPMIDPGVGVIVTIVALICTIILVSFQRWVVRRTQSQAVRADMLHYQSDVMMNGAILLALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDEERQEIIDIVTSWPGVSGAHDLRTRQSGPTRFIQIHLEMEDSLPLVQAHMVADQVEQAILRRFPGSDVIIHQDPCSVVPREGKRSMLS
What is the function of this protein?
Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+).  May be involved in zinc and iron detoxification by efflux.
What are the official names of this protein?
Cation-efflux pump FieF.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YHBP_SALEP
Sequence: MDTLTAIGRWLAKQHVVTWCVHHEGELWCANAFYLFDAQNVALYLLTDDKTRHAQMSGACAPVAGTVNGQPKTVARIRGVQFKGEIRRLEGQESDAARKAYLRRFPVARVLPAPVWEIRLDEIKFTDNTLGFGKKLHWLRDSRAQQA
What are the official names of this protein?
UPF0306 protein YhbP.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: ASTD_ECO45
Sequence: MTLWINGDWVTGQGALRVKRNPVSGEVLWQGNDADAAQVGQACRAARAAFPRWARLSFGDRQVRVERFAGLLESNKAELTAIIARETGKPRWEAATEVTAMINKIAISIKAYHVRTGEQRSEMPDGAASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGDAVMRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGSANTGYQLHRQLSGQPEKILALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLFLKSGTQGDAFLARLVAVSQRLTPGTWDDEPQPFIGGLISEQAAQQVVTAWQELEAMGGRTLLAPRLLQAGTSLLTPGIIEMTGVTGLPDEEVFGPLLRVWRYDNFDEAIRMANNTRFGLSCGLVSPEREKFDQLLLEARAGIVNWNKPLTGAASTAPFGGIGASGNHRPSAWYAADYCAWPMASLESDSLTLPATLNPGLDFSDEVVR
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: GSTA6_RAT
Sequence: MAEKPLFHYDEARGRMESVRWLLAAAGVEYEEKFIHTNEDLEKLRSDGVLMFQQVPMVEVDGMKLVQTRAIMNYFSSKYNLYGKDMKERALIDMYSEGLADLNEMFILYPFDPPGVKEANIALMKEKATNRYFPAFEKVFESHGQDYLVGNKLSKADVHLVEMIYNMEELDTNILANFPLLQALKTRISDMPTIKKFLQPGSQRQPPVDEKSIQKTRKIFKF
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase A6, GST class-alpha member 6.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCD93_DICDI
Sequence: MEKRKSIFFANDSEDNTSSGDLSSFTKRGTITPGKIANAREGELSQMIDVESEQKYQEIIELLVTGGYFRARISGLSPFDKVVGGMAWSITASNVDVDADLFFQENSNIKQKVSLSEELIKALNRMKCPFPLQAQHITLLNYITLFPIIRWLITKVIETREETGDLLRMYSISMFSKDYIAPIDEDMKKSLNESCDFIESVEKRYKPTRKFKRANNTKSTPTQTLLEYGKLHRISRLPTNINENKEAAQKLESQLSGKDGSGKDTTEAEREEEEKRIKQMMKGMKGVEGDALSKVSGGVLKSFLPSEEITNLSERYGDMSDLGGAEGAKMMAEKLHRQKITNLEKLIQQKNQELEQIINAHSERQTELEQLQLLVGKKQAFNERIIRETEKLDALETPENTKALQALRSLVLLNETLIAQEELFKQSCKRQMVEYKQKIEQLLSQDASTQEDLQDSDRQQQIQQAFDSDIGKLKKLKLLLNKKNRDISLIQRYLDELPSRAELLQYQRQFVELSEQSSSKLTETRQYYTTYNTFEDKKTLLENELSILNSIQSKYSIAMSSTNNKELFIKSMDQIIDGIQQVLDKSENKWNVEKVRHDTLSDQYMTLLDQERNYYKLTKDFEEECRKNELLIKKLNELQ
What are the official names of this protein?
Coiled-coil domain-containing protein 93 homolog.
What is the protein family that this protein belongs to?
Belongs to the CCDC93 family.
Protein: E4PD_VIBVU
Sequence: MLKVAINGFGRIGRNVLRAVYESGKHQQIKVVAVNELAQPEAMAHLLQYDTSHGRFGKRISHDQEHLYVHHDACPQGKGEFDSIRILHLSEINLLPWRDLEVDLVLDCTGVFGCQADGLEHIKAGAKKVLFSHPGASDLDNTIIYGVNHETLKAEHNVVSNGSCTTNCIVPIIKVLDEAFGIESGTITTIHSSMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVRVPTVNVTAMDLSVTINTNVKVNDVNQTIVNASQCTLRGIVDYTEAPLVSIDFNHDPHSAIVDGSQTRVSNGHLVKMLVWCDNEWGFANRMLDTALAMQAAQ
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL540_MIMIV
Sequence: MASNLTFEDKIGILDPKGLRPNPLNNEPYSDDYKKLAMVWSTYPAYSAADRVLSALENYQLVFVTSSTGSGKSVLIPKLALHYTNYNGRVVMTLPKRIITLSAAIFSAKVSDVKLGESIGYAYKGSDKSMYNDQNKIIYVTDGIFVMEYVRDPLLSKFNVVIIDEAHERRIQIDLILLFLRTLLQSGNRPDLKVIIMSATIDTDKYQKYFNSVDSTVIDIAGQPNHPIETHFMDKPVTSYMKEGLELIEDLIHQQIKKDMLFFITTSNEALQLCRSIRPQYPRVYCVEVYSDMDKNLKQYAESRDKYLELGNYDQKLVMATNVAESSLTIDGLVYVIDSGYELSSRFDPECYGQILEKKFVSKAQALQRRGRVGRTEPGVCYHLLTKQQFDGLADYPTPDILRQDITMDLIKIIQVSPNKTYAEGINMMNQLMDPPLRSHINATRNLFDLYNVVDDNGILTQVGIVATQFSSLPLNRILFLIYAFELQCAREASIIVAMTEFLNGRVTNLFYKSDTICESNCEKQAANLLLEKLIQKRGDHFTYLKIYQEFSKSTDQKSWARKYGVRLDTINNIERTANQYFYRILNLLRKPRLPNNKNTLIDTSIDTPMDIQSRISSTDTKTNLLNALKKSHQHLTASKLKPTYSKENITGKISRDSVLNQIYKKNEISKKKIIYDELSNINGKWEFRTVTIIS
What are the official names of this protein?
Putative ATP-dependent RNA helicase L540.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Virion.
Protein: PF12P_PLAF7
Sequence: MHIVSFIIFFFALFFPISICYKINGVCDFSSEGLSLLPEEKLDFSVSRNVDKLSDENNVRHCVHFSKGFEYLRFICPMRKDNYEGIEIRPVECFEYIHIEGREHKLSEILKGSLYEKSINDNIMTRDVFIPPTIYEDMFFECTCDNSLTFKNNMIGIRGIMKIHLKKNILYGCDFDHDEKLMKNKTAFTNFYDKQKILPLIGNNNNDDDNNDDDNNNDNNNNDNNNNNNNNNNNNNNNNNNNITCNVTIKKSQVYLGIICPDGYTLYPNDCFKNVIYDNNIIIPLKKIIPHDILYHQDKNKRITFASFTLNINENPPGFTCYCIKDQTNINNPLIVNFHFSNQETSYATKNKNLFFYFIFIFPFLYVILLL
What are the official names of this protein?
Surface protein P12p.
What are the subcellular locations of this protein?
Cell surface. Cell membrane.
Protein: MTB1_BACAM
Sequence: MRFFSVFDIVKNKANQLGYTETEMYAVLKNYNVNKKDLLAYKENGVIPTDKVLNGILSYLGMTKVELELKLGRIPAGLEDVFLNNTKEIAKILENKNSVKLNEFNSIQEIKPYFYTDLGKLYNGDCLELFKQVPDENVDTIFADPPFNLDKEYDEGVTDKNSFSGYLDWYYKWIDECIRVLKPGGSLFIYNIPKWNTYLSEYLNRKLNFRNWITVDMKFGLPIQNRLYPANYSLLYYVKGDKPKTFNVQRIPLQTCPHCGREIKDYGGYKNKMNPKGVTLSDVWSDIYPVRHSSSKNRKFNELSVKLLDRIITMSTNEGDVVLDPFGGSGTTFAVSEMLGRKWIGFELGNCEIIKERLKNKDKDKKLLGKVYEEKNKLFPNRVKELRKKNGLWIDDDFRQDHEGNSKGDKKNENNDQISLSLE
What is the function of this protein?
A beta subtype methylase, recognizes the double-stranded sequence 5'-GGATCC-3', methylates C-5 on both strands, and protects the DNA from cleavage by the BamHI endonuclease.
What are the official names of this protein?
Type II methyltransferase M.BamHI, M.BamHI, Modification methylase BamHI, N(4)- cytosine-specific methyltransferase BamHI.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: VIME_CHLAE
Sequence: MTTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLTEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESNEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE
What is the function of this protein?
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
What are the official names of this protein?
Vimentin.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Cell membrane.
Protein: PXPA_COPPD
Sequence: MPLKVDLNADMGESFGAYKLGLDRELLNLVTSANIACGFHAGDYMVMQKTVNMAASKNVAVGAHPGFPDLQGFGRRNMQLSPEEVRNLVIYQIGALQPFARAEGTELKHVKPHGALYNMAAVNYELAKAIAEAVKKTVPDAILLALANSEMVKAANDVGIRVTQEVFADRAYNEDGTLVPRSMPGAVIDDPLQATERALEMVLEGKVTAINGKEIPIVAHSICVHGDNPKAVELASSIRKQLEKAHVEVVELTYVLKAAYS
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: LEU1_PECCP
Sequence: MSEQVIIFDTTLRDGEQALQASLSVKEKLQIAFALERMGVDVMEVGFPVSSPGDFESVQTIARNIKNSRVCGLTRCVEKDIDVAAEALRVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMIKRARNYTDDVEFSCEDAGRTPIPDLCRVVEAAINAGARTINIPDTVGYTMPHEFGNIISSLYQHVPNIDKAIISVHTHDDLGLAVGNAMAAVHAGARQVEGTLNGIGERAGNCSLEEVIMAIKTRHNILNVHTNINHQEIYRTSQLVSQICNMPIPANKAVVGANAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDSDYNLDDLYSAFLKLADKKGQVFDYDLEALAFINRQQEEPEFYHLDYFSVQSGSSVMATASVKLICGEETQSEAATGNGPVDAVYQAINRITGYQVSLVKYQLTAKGQGRDALGQVDIVADYQGRRFHGVGLATDIVESSAQAMVNVLNNIKRAQQVEKEIQRLQQHNNQQQNDSKQQNSQETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: MTA70_ARATH
Sequence: METESDDATITVVKDMRVRLENRIRTQHDAHLDLLSSLQSIVPDIVPSLDLSLKLISSFTNRPFVATPPLPEPKVEKKHHPIVKLGTQLQQLHGHDSKSMLVDSNQRDAEADGSSGSPMALVRAMVAECLLQRVPFSPTDSSTVLRKLENDQNARPAEKAALRDLGGECGPILAVETALKSMAEENGSVELEEFEVSGKPRIMVLAIDRTRLLKELPESFQGNNESNRVVETPNSIENATVSGGGFGVSGSGNFPRPEMWGGDPNMGFRPMMNAPRGMQMMGMHHPMGIMGRPPPFPLPLPLPVPSNQKLRSEEEDLKDVEALLSKKSFKEKQQSRTGEELLDLIHRPTAKEAATAAKFKSKGGSQVKYYCRYLTKEDCRLQSGSHIACNKRHFRRLIASHTDVSLGDCSFLDTCRHMKTCKYVHYELDMADAMMAGPDKALKPLRADYCSEAELGEAQWINCDIRSFRMDILGTFGVVMADPPWDIHMELPYGTMADDEMRTLNVPSLQTDGLIFLWVTGRAMELGRECLELWGYKRVEEIIWVKTNQLQRIIRTGRTGHWLNHSKEHCLVGIKGNPEVNRNIDTDVIVAEVRETSRKPDEMYAMLERIMPRARKLELFARMHNAHAGWLSLGNQLNGVRLINEGLRARFKASYPEIDVQPPSPPRASAMETDNEPMAIDSITA
What is the function of this protein?
Catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs (PubMed:18505803, PubMed:28503769).  Associates with MTB, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences (PubMed:28503769).  N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:18505803, PubMed:28503769).
What are the official names of this protein?
N6-adenosine-methyltransferase MT-A70-like, Protein EMBRYO DEFECTIVE 1706, Protein METTL3 homolog.
What is the protein family that this protein belongs to?
Belongs to the MT-A70-like family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CC181_MOUSE
Sequence: MDEDKDIDSKESGEYEDDFEKDLEWLINDKEKSNGSTIEMACKKEDDLDQVLKENETETELGQQLSDPDNSPKDEALPRRNDFISVPSIQPLDPISDSDSENSFQDSKPENQKDLEDEEDEEVRRYIMEKIIEANKLLQTQEPVNDKRERKLKFKDKLVDLEVPPLEDSDTCKALLENETNMSGKLSQLCISGDLEQESVLVSVTDGSCEENDRKILVERDGKFELMNLQDIESQGFLPPISSANSVEHESSQLPLRAPNPSVGGIKKEESEAKGHVLPISPAGEPLAQVPQLLPNPKNRPSSAANPDVTKKARRSNHRIQSAGVSPVTSTYCLSPRQKELQKQLERKREKLKREEEQRKLEEENEKKKENEMVFKAWLQKKREQVIEMRRVQRAKQIEDMSSRQVNRDPQQAFRLWLKKKHEEQMKERKTEELRKQEECLFFLRGTEGRERAFRQWLRRKQIEKIAEQQAVKERARQLRLEARRSKQLQSSLYSIPEAKAFRFTDHYN
What is the function of this protein?
Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
What are the official names of this protein?
Coiled-coil domain-containing protein 181.
What is the protein family that this protein belongs to?
Belongs to the CCDC181 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localizes to the microtubular manchette of elongating spermatids (PubMed:28283191). Localizes to the sperm flagella and to the basal half of motile cilia (PubMed:28283191).
Protein: FLH2_CAEEL
Sequence: MVDTMMNTNTDGVTAVPPIFPLPSTTPNRNNNNELAMLAQKQIVAGLLLQQPTIVQAAVNGTNSQKHLADIDYTNVIQTLQALGTTNLKAFSLLLDPQSQTSQLISEDTRPSASSSPSSTATAVSNSGQSNATSTSSSSTEPEYKPRNVREKVYADGYIMSFDKKSCCGTKEFWRCERKNDCNARMHSDINTREIVRKLHPHNHEKPSPEELAFYEQDFSTLHPNYCHPVKSINRSYMQRKLSRASHVSQALPIAPQQIKAEPMEVDTTNQTIQNFQQNNNLMLLASINAAATAAAAATSAGISPPVVGQKRVSTTVMPITLKSQRTTPKEEEDSSQLMSQEEFRITYELTKKLMEMMKPKTEIGVRWQGDEGSILLFLSHDNGAEENVFFPVVVMNRDEKSLITALEGFTGKRCEGKLALCYSQRVNVLVHEALISNWTHGKLFLVNTDAPALWRLTPVDAFGEPLNHV
What is the function of this protein?
Probable transcription factor (PubMed:18794349).  May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-1 and flh-3 (PubMed:18794349).
What are the official names of this protein?
FLYWCH transcription factor 2.
Protein: SAMP_MUSCA
Sequence: GFPGKSLIF
What are the official names of this protein?
Serum amyloid P-component, SAP.
What is the protein family that this protein belongs to?
Belongs to the pentraxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS7_BORBR
Sequence: MPRRREVPKREILPDPKFGSVELAKFMNVVMLDGKKAVAERIIYGALEQVQVKTGKDAIEVFNLAINNIKPIVEVKSRRVGGANYQVPVEVRPVRRLALAMRWLREAAKKRGEKSMDLRLAGELIDASEGRGAAMKKREDTHKMAEANKAFSHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: TRPC_BURO0
Sequence: MSDILDRIIAVKREEIAAALRSTPLEALKLEASARDLRDFVGALRAKHAAGNAAVIAEIKKASPSKGVLREHFVPADIARSYAAHGAACLSVLTDEQFFQGGVRYLEEARAACTLPVLRKDFIVDAYQIVEARAMGADAILLIAAALDTPLMQDLEAYAHSLGLAVLVEVHDRHEMEQALTLKTPLLGINNRNLRTFETSIQTTLDMLDMIPADRIVVTESGILSRTDVDTMRAANVNTFLVGEAFMRAEQPGEELARMFF
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: OPP29_HAEIF
Sequence: MKKTLAALIVGAFAASAANAAVVYNNEGTNVELGGRLSVIAEQSNSTRKDQKQQHGELRNAGSHFHIKATHNFGDGFYAQGYLETRLVSDYQSSSDNFGNIITKYAYVTLGNKGFGEVKLGRAKTIADGITSAEDKEYGVLENKEYIPKDGNSVGYTFKGIDGLVLGANYLLAQKREAYKTDAATPGEVIAQAISNGVQVGAKYDANNIIAGIAYGRTNYREDLAELGNKSGKKQQVNGALSTLGYRFSDLGLLVSLDSGYAKTKNYKDKHEKRYFVSPGFQYELMEDTNVYGNFKYERNSVDQGKKAREHAVLFGVDHKLHKQVLTYIEGAYARTRTNDKDKTEKTEKEKSVGVGLRVYF
What is the function of this protein?
Forms pores that allow passive diffusion of small molecules across the outer membrane.
What are the official names of this protein?
Outer membrane protein P2, OMP P2.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: VSI3_TRYBB
Sequence: MFKNINAAVLLLILSTRNDYANAAAGDNENLFLDLCNLLELGKRAVSKLAPTNLGELAYSEIQKLNMSLSDDAWKAKFAPKKGKQENSNNADGAPRSQEKTHARNHAWRQAATDLAGDEGDKPTLRLAGLEAVTQVEKLQYLSALQPLAERAAAILEQLKTLHSGSAGLTDTNIRQEIQTALYGTGATAPEKTTLQLLKGKGNVGSTRKDICGQDNTAAKADTVLAYLFCICAGHATDSGGAIKVCSQTQPANNKADADVSDAHTHAAALAGQCHGSDTTNDIKAAEIDSAILEFTSKLKAANQKPYFGKYSATGCTGSDAEGICVMFKTTAKGEGKAVKQIPWVLTLHNAAEMIRKQQAVNGKIDSLNQELQAIQTAAYALKPQLEMYKRLQQTTEKARPGKQLTEMQAGECNTHKSNSTCPKNNCKWEEKDGKDGKCVADDSKVTTQGNAPAGAGDGTAGTTTTPNCASHTDKTKCEEENKGKTTPVCGWRKGKEGESDQDKEMCRNGSFLAKKKFALSVVSAAFTALLF
What is the function of this protein?
VSG forms a coat on the surface of the parasite.  The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
What are the official names of this protein?
Variant surface glycoprotein ILTAT 1.23, VSG.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Note=A soluble form is released from ruptured cells by the action of a PI-PLC.
Protein: RS10_PSEPG
Sequence: MQNQQIRIRLKAFDHRLIDQSTQEIVETAKRTGAQVRGPIPLPTRKERFTVLVSPHVNKDARDQYEIRTHKRVLDIVQPTDKTVDALMKLDLAAGVEVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RS12_CAMJE
Sequence: MPTINQLVRKERKKVLEKSKSPALKNCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTSGFEVISYIGGEGHNLQEHSIVLVRGGRVKDLPGVKYHIVRGALDTAGVAKRTVSRSKYGAKRPKAGAAK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SERC_COXB2
Sequence: MSRVYNFSAGPAAIPEEVLFTVRDELLDWHGIGMSIAEVSHRGEEFIGVAEEAERDLRELLAVPESYHILFLQGGSRLQFAMVPMNLLANHKKAVYIDSGVWSNLAIREAKNYCDPHLATNAKELNYTGIPDQATWDMPNEAAYFYYVDNETVNGIEFPFIPDTDLTLVCDMSSNLLSRPFDVSRYGLIFACAQKNMGLAGLTIVIVHDDLLKRSPLPTTPSYLQYALHAKERSFINTPPTFAWYLAGLIFKWVKNQGGVAVLAERNQRKAAKLYKFIDKSNFFDNPINPTYRSRMNVIFRLADERLNSLFLKEATENGLANLKGHRLLGGMRASIYNAMTEEGVDALINFMGQFEKRHG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MP2K4_MOUSE
Sequence: MAAPSPSGGGGSGGGGGTPGPIGPPASGHPAVSSMQGKRKALKLNFANPPVKSTARFTLNPNTTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQMPATPSSPMYVD
What is the function of this protein?
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.  With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.  MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif.  MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue.  The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs.  MAP2K4 is required for maintaining peripheral lymphoid homeostasis.  The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.  Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4, MAPKK 4, C-JUN N-terminal kinase kinase 1, JNK kinase 1, JNKK 1, JNK-activating kinase 1, MAPK/ERK kinase 4, MEK 4, SAPK/ERK kinase 1, SEK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.