PharMolix/UniProtQA huggingface dataset:
Protein: MCY1_YEAST
Sequence: MSCSQNKTSVSLAWRECISIASVLIGAYASYKYYKLFKTRDIPRPKEGVEELIGNTPLVKIRSLTKATGVNIYAKLELCNPAGSAKDRVALNIIKTAEELGELVRGEPGWVFEGTSGSTGISIAVVCNALGYRAHISLPDDTSLEKLALLESLGATVNKVKPASIVDPNQYVNAAKKACNELKKSGNGIRAVFADQFENEANWKVHYQTTGPEIAHQTKGNIDAFIAGCGTGGTITGVAKFLKERAKIPCHVVLADPQGSGFYNRVNYGVMYDYVEKEGTRRRHQVDTIVEGIGLNRITHNFHMGEKFIDESIRVNDNQAIRMAKYLSVNDGLFVGSSTAINAVAAIQVAKTLPHGSNIVIIACDSGSRHLSKFWKEAKEIDHDVSLEEVINI
What is the function of this protein?
Putative cysteine synthase that catalyzes the conversion of O-acetyl-L-serine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway.  However, this CS-like protein is unlikely to function in cysteine biosynthesis.  It seems that in S. cerevisiae cysteine biosynthesis occurs exclusively through the cystathionine pathway and not via direct incorporation of sulfur into OAS.
What are the official names of this protein?
Putative mitochondrial cysteine synthase, CS, Cysteine synthase-like protein, CSl, O-acetylserine (thiol)-lyase, OAS-TL, O-acetylserine sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Selective removal from mitochondrial outer membrane is achieved by sorting into a mitochondrial-derived compartment, or MDC, followed by release through mitochondrial fission and elimination by autophagy.
Protein: ARP2A_XENLA
Sequence: MDSQGKKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPVIRSTAKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRDCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRVIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRAEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGTRVLEKLGVTVR
What is the function of this protein?
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:17178911).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:17178911).  Seems to contact the pointed end of the daughter actin filament (PubMed:17178911).  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable).  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
What are the official names of this protein?
Actin-related protein 2-A, Actin-like protein 2-A.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Protein: K1PF_MYCGE
Sequence: MTWLQNITKESKIWIVNYACAIDYYVDLNKQKNSVLIPGGKGINVAIVMKSLGFDPTVITFLGQPTKNLFLELVKPYDLNIVSFISETKTRINLKLLKDEKTTEINDLSPLITDANLTELLTFLKANVKNNDLVIINGRFKFEALEKVLNLVFTLTENVVIDVDESKMLTLLNQSKPLVMKPNIDEFQTMINTFFHDQQSLIAAIKKFHYCKLLLLSDGDKGAYLFDQNKLLFVSSITPKQVVSTTGAGDTLLAVFLANLILKVDLKTALIKATNYASATISKLGVVDSKDKISVITPKSYYL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.
What are the official names of this protein?
Putative 1-phosphofructokinase, Fructose 1-phosphate kinase, Fru1PK.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: GRL1A_RAT
Sequence: MCSLPRGFEPPAPEDLGRQSSAELRERLRRQERLLRNEKFICKLPDKGKKISDTIAKLKAAISEREEVRGRTELFHPVSVDCKLRHKATTRVDTDIDKAQNSDLMLDTSSLVPECSSVDIESSKTTSETQGPTHLTHKGNEETLATGCTVNTCPSARITTQDPSSEVNEHLPQHSSQVEEISSSVDSLFITKLQKITIADQTEPSEENTSTENFPGLQSETPKKPHYMKVLEMRAKNPVPPPHKFKTNVLPTQQSDSSSHCHKGQSPASSEEHRRRARQHLDDVTAARLLPLHHLPAQLLSIEESLALQKEQKQNYEEMQAKLAAQKLAERLNIKMQSFNPEGESSGRYREVRDEDDAQSSDEC
What is the function of this protein?
Appears to be stable component of the Pol II(G) complex form of RNA polymerase II.  Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery.  May play a role in Mediator-dependent regulation of transcription activation.  In vitro, acts as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit GRINL1A, DNA-directed RNA polymerase II subunit M, Glutamate receptor-like protein 1A.
What is the protein family that this protein belongs to?
Belongs to the GRINL1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TES_XENLA
Sequence: MELENKFKKVTLGHEEGSGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHSVLSNNEDDRKVGKLFEDTKYTALIAKLKTDGIPTYKRNVMILTSPVAAKKDVSINTVTYEWAPPVQNQALARRYMELIPKDKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPNEVKQMEQFVKKYKNEVLGVGDVKLPKEVEAQASGAGRSTNGSLSTLTTVKSTDDKVAAQKGSTYYCFRCKENMREGDPAVYAERAGYDKLWHPSCFVCFTCNELLVDMIYFWKNGKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAEGLNWHLKHFCCFDCDIVLAGEIYVMVNDKAVCKPCYVKNHAVSCQGCHNAIDPEVQRVSYNGFHWHAAPECFICSCCSKCLIGQKFMPIEGMVFCSVECKKKMSS
What is the function of this protein?
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton.  May inhibit cell growth (By similarity).  Regulates cranial neural crest migration.  Acts together with prickle1 to control axial elongation.
What are the official names of this protein?
Testin, Xtes.
What is the protein family that this protein belongs to?
Belongs to the prickle / espinas / testin family.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
Protein: GLGS_ECOL6
Sequence: MDHSLNSLNNFDFLARSFARMHAEGRPVDILAVTGNMDEEHRTWFCARYAWYCQQMMQTRELELEH
What is the function of this protein?
Major determinant of cell surface composition.  Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.
What are the official names of this protein?
Surface composition regulator.
What is the protein family that this protein belongs to?
Belongs to the GlgS family.
Protein: Y043_OSHVF
Sequence: MSNLFIPRSTKRAVYDGPLPMVGSSLPPIEINSKGDKSVVYLRGDDQPIDVNREHRMVKVTYNEYDEQETIKVIFLDKKATIKDLHNLMSVGRDLTTGVCNIEVQPEYGFTLRIPDPDKLKYKSDIDAVYRLFASKYDNSDLFERASESLAFQITLDMNRERKDPKVLGITGDARGWETAPDLIGDYMDVVTNNYMSRYMKGV
What are the official names of this protein?
Uncharacterized protein ORF43.
Protein: ERPA_NITEC
Sequence: MNTITHEEANTVQPPLFFTDSAASKVKELIEEEANQALKLRVFVSGGGCSGFQYGFTFDEIINEDDFVIEKQGVRLLVDSMSVQYLLGAEIDYQENAQGAQFVIKNPAAASTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: MURQ_PROMT
Sequence: MSDTNNHSKNIIHRILTEQINLTSNELDTKSTKEIVNIFSEADKEPQKAVERVIPELINAIDEITSRLKSNGRLFYIGTGTSGRLGVLDASECPPTFCTNPDLVQGIIAGGISSLTTSSEHLEDVSEIAISDLKDRNFSYRDVLIGITASGRTPYVLGALNYSKSISALTISISSVPERDSTLDNDIDIRLITGPEILAGSTRLKAGTATKMALNIISTSVMIKLGKVYGNRMIDLSVSNDKLLDRAIGILFDIGSVDKVTAVQLLKKTNGSVKLSLLIALSGMDVIDAKQLLNDSKGNLRTALIRVKGN
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: RISB_SALPK
Sequence: MNIIKANVAAPDARVAITIARFNQFINDSLLDGAVDALTRIGQVKDDNITVVWVPGAYELPLATEALAKSGKYDAVVALGTVIRGGTAHFEYVAGGASNGLASVAQDSGVPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVLKAIKA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: CA131_DROME
Sequence: MLTINLLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSSLENIITYKRKLSFRTKYLNKYGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLRWSFKIAAQTTMGSEVKHDEHFKNGSLVESFESLISHSTLNILMPLVQNRMISKICGYDKLRADNFSRIQKMLDNVVNKKVNPLPKTDSDPESNIVINRAMELYRKGDITYMDVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLVYVDNMTMKLAEYPRLKLQRRG
What is the function of this protein?
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Probable cytochrome P450 313a1, CYPCCCXIIIA1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: MNMA_THET8
Sequence: MKRVLVAMSGGVDSSVAALLLKEAGYEVVGAMMRFWPDLPPPSLEAGKPRAWESCCTPDAAYEARRVADRLGIPFYLLDYREVFEEEIISPFLQDYAQGRTPNPCARCNTFVKFGALLKQARRLGLDYVATGHYVRKEGLALLRGLDPHKDQTYFLWGTPKEALPHLLFPVGGLTKPEVRALAEKAGLPTARRPESQNLCFVAGDLKGFLKERLKPRPGPLVDALTGEVVGEHEGASLYTLGQRKGLGLYKTHLERYVVGVDPERNVVYVGPKEACYFEGLEGEGLNLLAELPEEVEVQVRYRTPPVRAKVESLSPLRLRFAHPVFAVTPGQSAVFYRGERLLGGAVIRRGLYNLAGLEDPRALTFS
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_BUCAP
Sequence: MTANINKLARKNIQKLNPYQSARRIGGKGDTWLNANESPISVPFKGKVKVFNRYPECQPNNLLSSYANYVGLLNNQILVTRGADEGIELLIKAFCEPGKDAIIYCPPTYDMYAINAKIANVEIKEIPTFKNTWKIDLLNIRSNLNKVKLIYICNPNNPTGNIVSQEDLKSLLKVTLGQSLVIIDEAYIEFSPKNSMVNYLKTFPNLIILRTLSKAFALAGIRCGFTLAQKEVIDILHKVISPYPISTLIADIAVQSLEKKAIDDMKNRVLKLNMNRIWLIDELKKISCVKKVFDSHANYILVEFYMFKKIFQSLWQKGIILRNQNHKNNLKNCLRISIGSKSECMRLVQELKNFI
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: DEAH2_ARATH
Sequence: MGTERKRKISLFDVMDDPSAPAKNAKTSGLPDGGINSLINKWNGKPYSQRYYDILEKRRTLPVWLQKEEFLKTLNNNQTLILVGETGSGKTTQIPQFVIDAVDAETSDKRRKWLVGCTQPRRVAAMSVSRRVAEEMDVTIGEEVGYSIRFEDCSSPRTVLKYLTDGMLLREAMADPLLERYKVIILDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATLEAEKFQDYFSGAPLMKVPGRLHPVEIFYTQEPERDYLEAAIRTVVQIHMCEPPGDILVFLTGEEEIEDACRKINKEVGNLGDQVGPIKVVPLYSTLPPAMQQKIFDPAPEPVTEGGPPGRKIVVSTNIAETSLTIDGIVYVIDPGFAKQKVYNPRIRVESLLVSPISKASAHQRSGRAGRTRPGKCFRLYTEKSFNNDLQPQTYPEILRSNLANTVLTLKKLGIDDLVHFDFMDPPAPETLMRALEVLNYLGALDDDGNLTKTGEIMSEFPLDPQMAKMLIVSPEFNCSNEILSVSAMLSVPNCFIRPREAQKAADEAKARFGHIEGDHLTLLNVYHAFKQNNEDPNWCYENFINNRAMKSADNVRQQLVRIMSRFNLKMCSTDFNSRDYYINIRKAMLAGYFMQVAHLERTGHYLTVKDNQVVHLHPSNCLDHKPEWVIYNEYVLTSRNFIRTVTDIRGEWLVDVASHYYDLSNFPNCEAKRVIEKLYKKREREKEESKKNRK
What is the function of this protein?
May be involved in pre-mRNA splicing.
What are the official names of this protein?
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2, DEAH RNA helicase homolog PRP43.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. PRP43 sub-subfamily.
Protein: CABP4_BOVIN
Sequence: MAEEQGRGRHGPDPAPRPQKPPVEVLASSSGAEGPPLMRKRSSKREKGLRGSRKGPSSSGEQTPMQGPEAPGSSKNPSRTREGQEGPIPSASGLAPRRQSHRHRPGPQHDAAQRMYGPLLNRIFGKDRELGPEELDELQAAFEEFDTDHDGYIGYRDLGECMRTLGYMPTEMELIEVSQHVKMRMGGRVDFEEFVEMMGPKLREETAHMLGLRELRIAFREFDRDRDGRITVAELREAAPALLGEPLVGPELEEMLQEVDLNGDGTVDFNEFVMMLSRH
What is the function of this protein?
May play a role in normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission.  Modulator of CACNA1F, shifting the activation range to more hyperpolarized voltages (By similarity).
What are the official names of this protein?
Calcium-binding protein 4, CaBP4.
What are the subcellular locations of this protein?
Cytoplasm. Presynapse. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.
Protein: SLYX_BRUMB
Sequence: MSAEERLIELEIRVAEQEKTIDELSSVLTEQWKTVDQLSKKLNALTNRFLELEEQAAPDVPVTKPPHW
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: PTH_ECO81
Sequence: MTIKLIVGLANPGAEYAATRHNAGAWFVDLLAERLRAPLREEAKFFGYTSRVTLGGEDVRLLVPTTFMNLSGKAVAAMASFFRINPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRIGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTEMWFTDGLTKATNRLHAFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_SHEB2
Sequence: MAAKIRREDEVIVLAGKDKGKRAKVSQVLPTGKLIVEGINLVKKHQKPNPQLGVAGGIVEKEAPIQASNVAIFNSATGKADRVGFRFEDGKKVRFFKSNSELVK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: DEOB_LACLM
Sequence: MPKKFGRIHLVVMDSVGIGAAPDADKFFNHDVETHEAINDVKSDTIGHISEIRGLDVPNLQKLGWGNIPRESPLKTIPAAQKPAAYVTKLEEISKGKDTMTGHWEIMGLNIQTPFPTYPEGYPEDLLEKIEEFSGRKIIREANKPYSGTAVIEDFGPRQLETGELIIYTSADPVLQIAAHEDVISREELYKICEYVRSITLEGSGIMIGRIIARPYVGEAGNFERTDGRRDYALSPFAETVLEKLYKAGIDTYSVGKISDIFNTVGVKYDMGHNHNDMDGVDRLLKAMTKTEFTEGFSFTNLVDFDAKYGHRRDVEGYGKAIEDFDGRLPEIIDAMKEDDLLMITADHGNDPSYVGTDHTREYIPLVIFSKSFKEPKVLPVGHFADISATIAENFSVKKAQTGESFLDALV
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_STRPD
Sequence: MVLPTVAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYATGEWLNRQFSLIDTGGIDDVDAPFMEQIKHQAQIAMEEADVIVFVVSGKEGVTDADEYVSKILYRTNTPVILAVNKVDNPEMRNDIYDFYSLGLGDPYPVSSVHGIGTGDVLDAIVENLPVEEAEENDDIIRFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFTDADGQEFTMIDTAGMRKSGKIYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDKRIAGFAHEAGKGMIIVVNKWDTLDKDNHTVAKWEADIRDQFQFLTYAPIIFVSALTKQRLNKLPDLIKRISESQNKRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVSVKPPTFVVFVNEEELMHFSYLRFLENQIRAAFTFEGTPIHLIARKRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PCKG_BURPS
Sequence: MTRSNVVAATRTVPIDVPEYVKHRGLIDWVARIAELTEPDRVVWCDGSQQEYDRLCDAMVEQRTMVRLNPAKRPNSFLALSDPSDVARVEDRTFICSEHRDDAGPTNHWVAPAEMRATLNGLFRGAMRGRTLYVVPFSMGPLGSPIAHIGVELSDSPYVVVNMRIMTRMGRAVLDALGERGEYVPCVHSVGRPLAAGEQDVPWPCNPTKYIVHFPESREIWSFGSGYGGNALLGKKCFALRIASTMGRDEGWLAEHMLILGVTSPEGRKYHIAAAFPSACGKTNFAMLIPPKGFEGWRVTTIGDDIAWLKPGRDGRLYAINPEAGYFGVAPGTGEKTNPNALATLRENVIFTNVALTEDGDVWWEGLTDTPPARLTDWQGNAWTPEIGRETGRKAAHPNSRFTAPASQCPSIDDDWENPGGVPIDAFIFGGRRSTTVPLVTEARDWIEGVYMAATMGSETTAAAAGQQGIVRRDPFAMLPFCGYNMSDYFSHWLALGEKLAAAGATLPKIYCVNWFRKDADGRFAWPGFGENMRVLKWMLDRIDGRGEGVEHAFGVTPRYEDLHWAGLAFSPAQYAQVTSMNPDEWRAELALHAELFDKLSARLPDALAETKARIEKRLGG
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLD16_RAT
Sequence: MKDLLQYAACFLAIFSTGFLIVATRTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSIYAEHPLKLVVTRALMITADILAGFGFITLLLGLDCVKFLPDEPHIKVRLCFVAGTVLLIAGTPGIIGSVWYAVDVYVERSSLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGALLTCCLYLFKDVGPERNYPYAMRKPYSTAGVSMAKSYKAPRTETAKMYAVDTRV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.  Involved in paracellular magnesium reabsorption.  Required for a selective paracellular conductance.  May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients.  Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity).
What are the official names of this protein?
Claudin-16, Paracellin-1.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: LSPA_SHEHH
Sequence: MPTNWKDSGLRWYWVVVLVFVADQLSKQWVLSNFELYESIQLLPIFNFTYVRNYGAAFSFLSDAGGWQRWLFTFVAVGFSVVLSVWLRQQPSKMWRLNLAYTLVIGGALGNLIDRLQHGFVVDFLDFYWNTSHFPAFNIADSAICVGAALIILDSFVTGKDDKKTDGIKE
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RABL3_MOUSE
Sequence: MASLDRVKVLVLGDSGVGKSSLVHLLCHNQVLGNPSWTVGCSVDIRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEVLNRDAVPTGVLVTNGDYDREQFADNQIPLLVIGTKLDQIHETKRHEVLIRTAFLAEDFNAEEINLDCTNPRSSAAGSSNAVKLSRFFDKVIEKRYFFREGNQIPGFSDRKRFGGGALKNFHCD
What is the function of this protein?
Required for KRAS signaling regulation and modulation of cell proliferation (PubMed:31406347).  Regulator of KRAS prenylation, and probably prenylation of other small GTPases (By similarity).  Required for lymphocyte development and function (PubMed:32220963).  Not required for myeloid cell development (PubMed:32220963).
What are the official names of this protein?
Rab-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
Protein: MYG_ERIEU
Sequence: MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLFKDHPETLEKFDKFKHLKSEDEMKSSEDLKKHGTTVLTALGGILKKKGQHEAQLAPLAQSHANKHKIPVKYLEFISEAIIQVLKSKHAGDFGADAQGAMSKALELFRNDIAAKYKELGFQG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PAND_ECOSM
Sequence: MIRTMLQGKLHRVKVTHADLHYEGSCAIDQDFLDAAGILENEAIDIWNVTNGKRFSTYAIAAERGSRIISVNGAAAHCASVGDIVIIASFVTMPDEEARTWRPNVAYFEGDNEMKRTAKAIPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_PHOPR
Sequence: MPELPEVEVSRMGITPHMVGQTVTKIIVRNPKLRWPIPEEIQQIEGQVIRKVTRRAKYLLLHTDVGYAIVHLGMSGSLRILPASIPPEKHDHVDLVLSSGEVLRYNDPRRFGAWLWGLPDLDHKVLSQLGPEPLSNDFTAEYLQERAKGKRTAIKQFIMDNKVVVGVGNIYANESLFSAGIHPKRAAGEISPEKIALFVDEIKSVLAFAIEQGGTTLKDFKNADGKPGYFAQELQVYGKGGKPCPRCDNPLSEMKIGQRASVFCSECQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: LRRC2_HUMAN
Sequence: MGHKVVVFDISVIRALWETRVKKHKAWQKKEVERLEKSALEKIKEEWNFVAECRRKGIPQAVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQHFDKEVMKAYIEDLKERESVPSYTTKVSFSLQL
What are the official names of this protein?
Leucine-rich repeat-containing protein 2.
Protein: TAGAP_MOUSE
Sequence: MKLISSLDGSKTLNANNMETLIECQSEGDIKVPPLLTSCESEDSICQLTEIKKRKKVLSWPSLMRKLSPSSDFSGSLEPELKVSLFDQPLSIICGENDTLPRPIQDILTILCLKGPSTEGIFRKAASEKARKELKEGLNCGVSVNLKQLPVHLLAVVFKDFLRGIPLKLLSCDLFEDWMGALEKPTEEDRIEALKQVAGGLPRPNLLLLRHLLYVLHLISKNAEVNKMDSSNLAICIGPNMLTLKNDQSLSFQAQKDLNNKVKILVEFLIDNCFEIFGENIRTRSRITSDDSLEHTDSSDVSTLQNDSAYDSNDPDVEPTSGAASPNRQLEGPTPTMAGLDTRGQRDTCESSSESSVSMVVRLKSSIVQQDRRFSEPNMSPSRECLVGPTSKQKLARSEDSFTLSQDASCSEGDEAEDPFTEEVFPAVDSKPKRPVDLKIKNWTQGLASPQGHITKAFSRSSPGESLGSSPVPSPSCPKRNFFTRHQSFTTKTDKTKPQREIRKHSMSFSFASHKKVLPRTSSIGSEKSKDFSRDQLQKDLRKESQLSGRIVQENESEIQSQTSLGFSLSGTWALSVDNTFQLVDMRKPGSPPSYEEAIYYQTSGLTAYGGQTVGSMRSRMFKPSTAVPPVPSHHGGDLSEGTPGGHRLSSVTEHWTHSQTVHVSIETQGRSELHQLRTVSESMQKAKLDCLGPQHSHLVFEADQLCCARESYI
What is the function of this protein?
May function as a GTPase-activating protein.  May play a role in transmission ratio distortion (TRD) in mouse, in which heterozygous males for t-locus transmit their t-carrying chromosome to 95% or more of their offspring.
What are the official names of this protein?
T-cell activation Rho GTPase-activating protein, T-cell activation GTPase-activating protein.