PharMolix/UniProtQA huggingface dataset:
Protein: MCRA_METTM
Sequence: MADKLFINALKKKFEESPEEKKTTFYTLGGWKQSERKTEFVNAGKEVAAKRGIPQYNPDIGTPLGQRVLMPYQVSTTDTYVEGDDLHFVNNAAMQQMWDDIRRTVIVGLNHAHAVIEKRLGKEVTPETITHYLETVNHAMPGAAVVQEHMVETHPALVADSYVKVFTGNDEIADEIDPAFVIDINKQFPEDQAETLKAEVGDGIWQVVRIPTIVSRTCDGATTSRWSAMQIGMSMISAYKQAAGEAATGDFAYAAKHAEVIHMGTYLPVRRARGENEPGGVPFGYLADICQSSRVNYEDPVRVSLDVVATGAMLYDQIWLGSYMSGGVGFTQYATAAYTDNILDDFTYFGKEYVEDKYGLCEAPNNMDTVLDVATEVTFYGLEQYEEYPALLEDQFGGSQRAAVVAAAAGCSTAFATGNAQTGLSGWYLSMYLHKEQHSRLGFYGYDLQDQCGASNVFSIRGDEGLPLELRGPNYPNYAMNVGHQGEYAGISQAPHAARGDAFVFNPLVKIAFADDNLVFDFTNVRGEFAKGALREFEPAGERALITPAK
What is the function of this protein?
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB).  This is the final step in methanogenesis (PubMed:2269306, PubMed:3350018, PubMed:27140643).  Neither N-6-mercaptohexanoylthreonine phosphate (H-S-HxoTP) nor N-8-mercaptooctanoylthreonine phosphate (H-SOcoTP) nor any other thiol compound such as CoA or CoM can substitute for CoB as the electron donor (PubMed:3350018).
What are the official names of this protein?
Methyl-coenzyme M reductase I subunit alpha, MCR I alpha, Coenzyme-B sulfoethylthiotransferase alpha.
What is the protein family that this protein belongs to?
Belongs to the methyl-coenzyme M reductase alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Under growth limiting conditions on nickel-depleted media, a fraction of 70% of the enzyme is localized close to the cytoplasmic membrane, which implies 'facultative' membrane association of the enzyme.
Protein: UBIE_BURMS
Sequence: MSKTHFGFETVEENEKAKKVAGVFHSVASNYDLMNDLMSAGLHRAWKAFTIAQANVRPGGKVLDIAAGTGDLTKAFAKAAGPTGEVWHTDINESMLRVGRDRLLDKGVVTPSLLCDAEKLPFPDNYFDVVTVAFGLRNMTHKDSALAEMRRVAKPGGRVMVLEFSKVWEPLKKAYDVYSFKVLPWLGDKFAKDADSYRYLAESIRMHPDQETLKTMMEQAGLDAVKYYNLSGGVVALHVGTKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: HFQ_ALIF1
Sequence: MAKGQSLQDPFLNALRRERIPVSIYLVNGIKLQGQIESFDQFVILLKNTVNQMVYKHAISTVVPARAVSHHSASDRPQGERPQEKTEE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: REX_BACTN
Sequence: MAENQKIQQIDCTKVPEPTLRRLPWYLSNVKLLKQRGERFVSSTQISKEINIDASQIAKDLSYVNISGRTRVGYEVDALIEVLEHFLGFTEIHKAFLFGVGSLGGALLQDSGLKHFGLEIVAAFDVDPTLVGTNLNGIPIYHSDDFLKKMEEYDVQIGVLTVPIEIAQCITDMMVDGGIKAVWNFTPFRIRVPEDIVVQNTSLYAHLAVMFNRLNFNEIK
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEX2_XENLA
Sequence: MAASENNMEEINPVLRISQLDAIELNKALEQLIWSQFSSCFQGFKPGLLTRFEPEIKASLCLFLWRYTIYTKNATVGQTILNMQYKNDLAVTKKYRPLNKQQKVWFALFLVGGKWLEERSFDLFSNHPFGASFQRTKYFLNAISGLLKFGALLNFLIFLQQGKFATLTERLLGIRSVFSRPQDVRQVGFEYMNREILWHGFAEFLIFLLPLINTQKLKSKLFSWCKPAKSHGVSDPSLAVICKECCLCGEWPAMPHTIGCSHVFCYYCIKSNYMSDMYFTCPKCSSQVHNLQPLEFKIEISEVHTL
What is the function of this protein?
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:35931083).  The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane.  PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity).
What are the official names of this protein?
Peroxisome biogenesis factor 2, Peroxin-2.
What is the protein family that this protein belongs to?
Belongs to the pex2/pex10/pex12 family.
Protein: ERA_STAAN
Sequence: MTEHKSGFVSIIGRPNVGKSTFVNRVIGHKIAIMSDKAQTTRNKIQGVMTRDDAQIIFIDTPGIHKPKHKLGDYMMKVAKNTLSEIDAIMFMVNANEEIGRGDEYIIEMLKNVKTPVFLVLNKIDLVHPDELMPKIEEYQSYMDFTEIVPISALEGLNVDHFIDVLKTYLPEGPKYYPDDQISDHPEQFVVGEIIREKILHLTSEEIPHAIGVNVDRMVKESEDRVHIEATIYVERDSQKGIVIGKGGKKLKEVGKRARRDIEMLLGSKVYLELWVKVQRDWRNKVNFIRQIGYVEDQD
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: CSPLN_ARALL
Sequence: MENVPGSFGTSASFALRFGQTIFSAASLIFMCFDYDFYDFTTFCYLATVMAIVTPWSILLALTDTYSVLVKLLPQELRVLSIVFAGDFVLSFLSLGGACAVASATELLASADGKICDGNLCIQYQVSAALAFLCWFLLLASALFNFWSLPSLYY
What are the official names of this protein?
CASP-like protein ARALYDRAFT_485429.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BACD2_MOUSE
Sequence: MSGDTCLCPASGAKPKISGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQSRQEIQELMAEAKYYLIQGLVSTCQTALQDKKDSYQPVCNIPIITSLREEDRLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEDTFELRDRVRRIHVKRYSTYDDRQLGHQSTHRD
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure.  The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.  Its interaction with RHOB may regulate apoptosis.  May enhance the PCNA-dependent DNA polymerase delta activity (By similarity).
What are the official names of this protein?
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2, BTB/POZ domain-containing protein TNFAIP1, Tumor necrosis factor, alpha-induced protein 1, endothelial.
What is the protein family that this protein belongs to?
Belongs to the BACURD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes.
Protein: RS3A1_SCHPO
Sequence: MAVGKNKRLSKGKKGIKKRVVDPFSRKDWYDIKAPAFFEVKNVGKTLVNRTAGLKNANDSLKGRILEVSLADLQKDEEHSFRKVKLRVEDIQGKSCLTSFNGFDMTSDKLRSLVRKWQSTIEANQTIKTTDGYLCRIFVIGFTSRRVNQVKKTTYAQSSQIRAIHQKMFQVIQNQANGCSMKELVQKLIPEVIGRAIEKATNNIYPLQNVFVRKVKILKAPKHDAQKLLELHGESQDVGSKVISDVAPLESV
What are the official names of this protein?
40S ribosomal protein S1-A, S3aE-A.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: Y436_SHEDO
Sequence: MEKVFEKLMYASRWIMAPIYLGLSLILFALGIKFFQEIFHLIPNIFEIAEVDLVLITLSLIDITLVGGLLIMVMFSGYENFVSQLDVGESSEKLNWLGKMDAGSLKNKVAASIVAISSIHLLKVFMNAENIANDKIMWYLLIHITFVLSAFAMGYLDKITRK
What are the official names of this protein?
UPF0114 protein Sden_0436.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ALGK_AZOVI
Sequence: MNLTKPLLLSALAGLTACANLDLPDQRLAKEALQRGDTQTAERHFRQLADMGFTEAQLGLADMQLASGDPEQLRKAEQTYRMALDASPRAKARLGKLLAYKPTSSEAEKREAAQLLSDAFAAGEDGVLLPLAMLYLKNPQTFPDVSLQQRIDQWRAAGHPQADIAQIVVYRTQGTYDQHLDDIERICQQRLAEHSDCYVELATVYLQARPEWTRTTACRAWCNSSWPLMAAHRAGGVSAQLVTEVAGVLSNPLLGQSNEKTAQTMLEEIAPPPGSVWRVLIYDFPGTGDTDQMLDYLAWPCAAQPAADLLLGRLYYEGKLLPQDPFKAEEYFIKARATENSAHYYLGQIYRRGFLGEVYPQKAVDSLLTAARGGQASADYALAQLYSQGRGIRIDLANAYVFARLAVLQGRPDSEPLLQEIKANLAPAERTRGEQMLHAEQQARYGVWQTSTQLQAMQNQ
What is the function of this protein?
May be involved in the polymerization of mannuronate to alginate.
What are the official names of this protein?
Alginate biosynthesis protein AlgK.
What is the protein family that this protein belongs to?
Belongs to the AlgK family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: MPGP_SHISS
Sequence: MFSIQQPLLVFSDLDGTLLDSHSYDWQPTALWLSRLREANVPVILCSSKTSAEMLYLQKTLGLQGLPLIAENGAVIQLAEQWQDIDGFPRIISGISHGEISQVLNTLREKEHFKFTTFDDVDDATIAEWTGLSRSQAALTQLHEASVTLIWRDSDERMAQFTARLNELGLQFMQGARFWHVLDASAGKDQAANWIIATYQQLSGKRPTTLGLGDGPNDAPLLEVMDYAVIVKGLNREGVHLHDEDPTRVWRTQREGPEGWREGLDHFFSAR
What are the official names of this protein?
Mannosyl-3-phosphoglycerate phosphatase, MPGP.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MPGP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLD_SHISS
Sequence: MNKILLQCDNLCKRYQEGSVQTDVLHNVSFSVGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFNGQPMSKLSSAAKAELRNQKLGFIYQFHHLLPDFTALENVAMPLLIGKKKPAEINSRALEMLKAVGLEHRANHRPSELSGGERQRVAIARALVNNPRLVLADEPTGNLDARNADSIFQLLGELNRLQGTAFLVVTHDLQLAKRMSRQLEMRDGRLTAELSLMGAE
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: WWOX_HUMAN
Sequence: MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
What is the function of this protein?
Putative oxidoreductase.  Acts as a tumor suppressor and plays a role in apoptosis.  Required for normal bone development (By similarity).  May function synergistically with p53/TP53 to control genotoxic stress-induced cell death.  Plays a role in TGFB1 signaling and TGFB1-mediated cell death.  May also play a role in tumor necrosis factor (TNF)-mediated cell death.  Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
What are the official names of this protein?
WW domain-containing oxidoreductase, Fragile site FRA16D oxidoreductase, Short chain dehydrogenase/reductase family 41C member 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Note=Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus.
Protein: PLSY_RHOPA
Sequence: MMIGIYIAALVIGYLFGSIPFGLILTKIAGTQDLRSIGSGNIGATNVLRTGRKGLAAATLLLDALKGTAAVIVAAYLASGTDAIAANAAMLAALGAFLGHLFPVWLKFKGGKGVAVYIGVLIGLFWPAAVVFCIMWLATAFTSRYSSLSALVASFVTPIFLWWFGHDSLASLFAVLTLLLFWMHRENIKRLQAGTESKIGQKK
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPG_YERPG
Sequence: MAGAKEIRSKIASVQNTQKITKAMEMVAASKMRKSQERMAASRPYAETMRSVIGHLALGNLEYKHPYLEERDVKRVGYLVVSTDRGLCGGLNINLFKRLLAEMKGWSEKGVECDLALIGSKAASFFGSVGGKIVAQVTGMGDNPSLSELIGPVKVMLQAYDEGRLDKLYIVNNKFINTMSQEPRIMQLLPLPPAEDGELKKKSWDYLYEPDPKALLDTLLRRYVESQVYQGVVENLASEQAARMVAMKAATDNGGSLIKELQLVYNKARQASITQELTEIVGGASAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LPTD_XYLFA
Sequence: MYRVLRLLPLPLSVAISLSALADEKPPNWGLCPATLPLQGFEQAPGMDKHVVQSRPQLPTNIEGDTLTGTARTPLYQGNVLMARGDQFLGADSVRMDTETDSYVAEGHVRYQDSSILVVADRAEGNQDTDVHKISNIQYQLIGRRGNGVAKSVDIHGQVGQTHEATYTTCDPSQAIWRLRAPEIDVDNVEGFGVARHAVFEVGQWPVLYLPWFKFPIDSRRQTGLLYPQLGYSGRNGFDYAQPIYLNLAPNYDATLYPRYMQKRGFMIDTEFRYLYDDGKWQTRAAFIPNDQLRDKDRGRFSFNGYHNIDNHWQARASLAWVSDTRYMEDFSSRLVGMSSLSSLQSTVGVYGTGETWTAGLMADRWQLTDYSLDESALAYNRQPRLFFNWDKPVFDFLEFGLYSEVVRFKHDDAYLVALQNDGNYLRTGEVIRYYGGTRLDVKPYLLLPFTGASWYVTPTFGWRYSSYYLDSGIAEQLNGNRTPVRSLPIISLDSGVYLDRDTSVFGRNYLNTLEPRFYYLYVPYRNQSDLPLFDTRAFTFSWGQLFRDSRYTGPDRQNDANQLTLAVTSRWLDQNTGKEDLALSVGQILYFKDSLVTLNDSEERIQQGKSVWVSDVAYNVNDRWTLNATYQWNPNFRRDDLASIRARYLIGSDGIINLAYRYRRNTLDGTTQLKQTDFSFLYPINPRWSAIGRYYYSLLDKKPLEIISGLQWDSCCLAVRTVLRRYMRDRTGNMDNSIQLEFVFKGLSSVGQDTDRVLRRAILGYYRDDLYLVPPSNTTTDPDAYDPNKIP
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: CRCB_ECO55
Sequence: MLQLLLAVFIGGGTGSVARWLLSMRFNPLHQAIPLGTLAANLIGAFIIGMGFAWFSRMTNIDPVWKVLITTGFCGGLTTFSTFSAEVVFLLQEGRFGWALLNVFVNLLGSFAMTALAFWLFSASTAH
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HD1_BRANA
Sequence: MQEAALGMIGATVGGGGDGDAAVVAEQNRQMKGEIATHPMYDQLLAAHVACLRVATPIDQLPIIEAQLSHSHHLLRSYASTAVGFSHHDRQELDNFLAQYVMVLCSFKEQLQQHVRVHAVEAVMACREIENNLHSLTGATLGEGSGATMSEDEDDLQMDFSSDNSGVDFSGGHDMTGFGPLLPTESERSLMERVRQELKLELKQGFKSRIEDVREEIMRKRRAGKLPGDTTTVLKNWWQQHCKWPYPTEDDKAKLVEETGLQLKQINNWFINQRKRNWHNNSHSLTSLKSKRKH
What is the function of this protein?
Possible developmental regulator.
What are the official names of this protein?
Homeobox protein HD1.
What is the protein family that this protein belongs to?
Belongs to the TALE/KNOX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYM_XANCP
Sequence: MTRTALVTTALPYANGPLHLGHLVGYIQADIWVRARRLRGDKTWFVCADDTHGTPIMLAAEKAGVTPEAFIANIQASHERDFAAFGVTFDHYDSTNSPVNRELTEAFYTKLEAAGHISRRSVAQFYDPAKGMFLPDRYIKGICPNCGSADQYGDNCEVCGATYAPTELKEPKSVISGATPELRDSEHFFFEVGHFDGFLREWLDGDVALPGVKAKLKEWLDAEGGLRAWDISRDAPYFGFQIPGQPGKYFYVWLDAPIGYLCSFKTLCAQMGEDFQAHLAAGTQTELHHFIGKDIVNFHGLFWPAVLHGTGHRAPTRLHVNGYLMVDGAKMSKSRGTFVMARTFLDVGLEPEALRYYFAAKSSGGVDDLDLNLGDFVARVNADLVGKFVNLASRCAGFIGKRFDGKLADALPDPAQYARFVEALAPIREAYERNDPASAIRQTMALADEANKYIDDTKPWVIAKQEGADAQLQSVCTQGLNLFRLLVAALKPILPRTAAEAEAFLSAPMTSWEDVSRPLTCHVIQPYTALFTRIDPKLIDAMTDASKDTMAAPAAPAATTASAEKVAKIDAKAATPANPPASVANPGLIGMDDFAKLDLRIGKVLVCEAVEGSDKLLRFELDAGELGKRQIFSGIRASYGEPETLVGRSVVFIANLAPRKMRFGISEGMILSAGFDGGALALLDADAGAQPGMPVR
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_LISIN
Sequence: MIVKICGLKKSVDVKAAVENGADMIGFVFAKSKRQVTIEQAHQLAKNIPPNIKKVGVFVNPTEDELTAAIKGVPLDIVQLHGQEPTEQADRTDAEVIKAFPVKEGKLPNNINDYSNAYILLDAPAEEYEGGSGKTFDWDKVNSDLLIKNKLIIAGGLNVENVKEAINRFEPYAVDISSGVETNGEKDPEKIKIFIKTAKGVGK
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: ATPE_HAEIG
Sequence: MATFNLTIVSAEQKIFEGEVKQIQVTGVEGELGILPGHTPLLTAIKPGIVKFTLKDGNEEVIYVSGGFLEVQPNIVTVLADIAIRGSELDADRIHEAKRKAEENIVSRGSDADHDLLVAKLSKELAKLRAYELTEKLLKTRR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CDC27_YEAST
Sequence: MAVNPELAPFTLSRGIPSFDDQALSTIIQLQDCIQQAIQQLNYSTAEFLAELLYAECSILDKSSVYWSDAVYLYALSLFLNKSYHTAFQISKEFKEYHLGIAYIFGRCALQLSQGVNEAILTLLSIINVFSSNSSNTRINMVLNSNLVHIPDLATLNCLLGNLYMKLDHSKEGAFYHSEALAINPYLWESYEAICKMRATVDLKRVFFDIAGKKSNSHNNNAASSFPSTSLSHFEPRSQPSLYSKTNKNGNNNINNNVNTLFQSSNSPPSTSASSFSSIQHFSRSQQQQANTSIRTCQNKNTQTPKNPAINSKTSSALPNNISMNLVSPSSKQPTISSLAKVYNRNKLLTTPPSKLLNNDRNHQNNNNNNNNNNNNNNNNNNNNNNNNIINKTTFKTPRNLYSSTGRLTTSKKNPRSLIISNSILTSDYSITLPEIMYNFALILRSSSQYNSFKAIRLFESQIPSHIKDTMPWCLVQLGKLHFEIINYDMSLKYFNRLKDLQPARVKDMEIFSTLLWHLHDKVKSSNLANGLMDTMPNKPETWCCIGNLLSLQKDHDAAIKAFEKATQLDPNFAYAYTLQGHEHSSNDSSDSAKTCYRKALACDPQHYNAYYGLGTSAMKLGQYEEALLYFEKARSINPVNVVLICCCGGSLEKLGYKEKALQYYELACHLQPTSSLSKYKMGQLLYSMTRYNVALQTFEELVKLVPDDATAHYLLGQTYRIVGRKKDAIKELTVAMNLDPKGNQVIIDELQKCHMQE
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.  In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition.  In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
What are the official names of this protein?
Anaphase-promoting complex subunit CDC27, Anaphase-promoting complex subunit 3, Cell division control protein 27.
What is the protein family that this protein belongs to?
Belongs to the APC3/CDC27 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CBPYA_BLAGS
Sequence: MKSLALALLVGGAIAAGPQQQVLQAPVDNPDVAEPPLQTIADTFDHLRGQATNLWNDVIDKVPNIMDTITHTPPPKKFNRRPDSEWNHIVRGAEIQAVWVEGDDGEKHRKVGGKLEAYDLRVKAVDPKALGVDTVRQYSGYLDDNENDKHLFYWFFESRNDPENDPVVLWLNGGPGCSSLTGLFLELGPSSITEDLKVNYNPYSWNANASVIFLDQPVNVGYSYSGGSVSDTNAAGKDVYALLTLFFEQFPEYAKQDFHIAGESYAGHYIPVFASEIMAHKERNINLKSILIGNGLTDPLTQYPLYRPMACGEGGYPAVLDQASCQSMDNALPRCLSMIEACYSSESAWTCVPASIYCNNAIIGPYQRTGRNPYDVRTDCEGGNLCYTQLGDISKYLNQAEVMKALGAEVSTYDSCNMDINRNFLFRGDWMKPFHRLVPGLIAEMPVLLYAGDADFICNWLGNKAWAEALEYPGHAKFAAAEMKNLTIVDNKSKGKVIGQVKSAGNFTFMRLYGGGHMVPLDQPEASLEFMNRWLKGEWSAKSSS
What is the function of this protein?
Vacuolar carboxypeptidase involved in degradation of small peptides.  Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).
What are the official names of this protein?
Carboxypeptidase Y homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: UBAP1_MOUSE
Sequence: MASKKLGTDVHGTFSYLDDVPFKIGDKFKTPAKVGLPIGFSLPDCLQVVREMQYDFSLEKKTIEWAEDIKLIQEAQREAERKAEEAEAKVNSKSGPEGDSKVSFPKTHNTATMPPPINPILASLQHNNILTPTRVSSSATKQKVLSPPHTKADFNPADFECEEDPFDNLELKTIDEKEELRNILVGTTGPIMAQLLDSNTARGSSGAVLQDEEVLASLEQATLDFKPLHKPNGFITLPQLGNCEKMSLSSKVSLPPIPTVSNIKSLSFPKLDSDDSNQKTVKLASTFHSTSCLRSGASRSLLKPSTQSSASELNGDHTLGLSALNLNSGTEVPTLTSSQMPSLSSVSVCTEESSPPDPCPTVTPLNFSVSQVPNMPSCPQAYLELQALSPSERQCVETVVNMGYSYDCVLRAMRKKGENIEQILDYLFAHGQLCEKGFDPLLVEEALEMHQCSEEKMMEFLQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLMARAGAS
What is the function of this protein?
Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:31203368).  Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (By similarity).  Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:31203368).
What are the official names of this protein?
Ubiquitin-associated protein 1, UBAP-1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endosome. Note=Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex.
Protein: Y1890_BACP2
Sequence: MKSFYHYLMKYRHPKPKDEISHFANAAYEDHSFPKASTDYHELSVYLELNGDYLSSMTTFDEAFEQYDVEVKKK
What are the official names of this protein?
UPF0346 protein BPUM_1890.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.