PharMolix/UniProtQA huggingface dataset:
Protein: SPIKE_SARS
Sequence: MFIFLLFLTLTSGSDLDRCTTFDDVQAPNYTQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHTINHTFGNPVIPFKDGIYFAATEKSNVVRGWVFGSTMNNKSQSVIIINNSTNVVIRACNFELCDNPFFAVSKPMGTQTHTMIFDNAFNCTFEYISDAFSLDVSEKSGNFKHLREFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNTLKPIFKLPLGINITNFRAILTAFSPAQDIWGTSAAAYFVGYLKPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNITNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAWRIYSTGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTVSLLRSTSQKSIVAYTMSLGADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDINARDLICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYVWLGFIAGLIAIVMVTILLCCMTSCCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT
What is the function of this protein?
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single- pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment (PubMed:20861307). Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion.
Protein: SYYC1_ARATH
Sequence: MADQSSEIVNALSSEMEAVSVSSTQASSSSDGFQMSEEVEKRYKIVRSIGEECIQEEELKNLLAKKAAPICYDGFEPSGRMHIAQGVMKVINVNKMTSAGCRVKIWIADWFAQLNNKMGGDLKKIRVVGEYFQEIWKAAGMDNDKVEFLWSSEEINSKADKYWPLVMDIARKNKLPRILRCVQIMGRSETDELSAAQILYPCMQCADIFFLEADICQLGMDQRKVNVLAREYCDDIKRKNKPIILSHHMLPGLQQGQEKMSKSDPLSAIFMEDEEAEVNVKIKKAYCPPKVVKGNPCLEYIKYIILPWFDEFTVERNEEYGGNKTYKSFEDIAADYESGELHPGDLKKGLMNALNKILQPVRDHFKTDARAKNLLKQIKAYRVTR
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase 1, cytoplasmic, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RL28_SYNJA
Sequence: MARRCQLTNKKRNNAFAISHSHRRTKRLQEVNLQWKRIWWEEGKRFVRLRLSTKALKTLKAKGIGAMAREAGIDLNQF
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: ACEA_PINTA
Sequence: MAIYSAQAPNSILEEEARFEAEVSETQAWWNSTDLFRLTRRPYTARDVVRLRGSMRQSYASNEMAKKLWRTLKTHQANKTASRTFGALDPVQVSMMAKYLDSIYVSGWQCSSTHTTTNEPGPDLADYPYDTVPNKVEHLFFAQQFHDRKQKEARMSMTREERSKTPYIDYLKPIIADGDTGFGGATATVKLCKLFVERGAAGVHIEDQASVTKKCGHMAGKVLVSVGEHVNRMVAARLQFDIMGVETLLVARTDAVAATLIQTNVDARDHQFILGATNPNLKGKPLADVLARAMASGKSGADLQAVEDEWMAMADLKLFSDCVVDGIKALNVSEQEKGRRLGEWMQQTGGNTGNVLSYYQAKELAEKLGISNLFWDWDLPRTREGFYRFQGSVKAAIVRGWAFGPHADIIWMETSSPDMVECRDFALGVKSKHPEIMLAYNLSPSFNWDASRMTDEQMKNFIPEIARLGYCWQFITLAGFHADALVIDTFAKDFAQRGMLAYVEKIQRQEMMNGVDTLAHQKWSGANYYDQLLKTVQGGISATAAMAKGVTEDQFEETQSSTLALESNIGAGTVLAKSRM
What is the function of this protein?
Involved in storage lipid mobilization during the growth of higher plant seedling.
What are the official names of this protein?
Isocitrate lyase, ICL, Isocitrase, Isocitratsysase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
What are the subcellular locations of this protein?
Glyoxysome.
Protein: RLMG_PSEPK
Sequence: MPLLTTPYAELDLIRQPEQANDPLQAFDAADEYLLAQLHDQAPDANCRVLVLNDSFGALAASLAGQLQVVSSGDSHLGHLALEKNLARNGLPFDSVPFVPASEHWQGPFDRVLVRVPKTLALLEEQLIRLQGQLAPGAQVIAGAMIKHLPRAAGDLMEKYIGPVQASLALKKARLLTATVAERPLAKSPYPSCYRLDAPALDLVNHANVFCREGLDIGTRAFLPHLPRNLGRARVADLGCGNGVLAIASALANPEAEYTLVDESYMAVQSAQENWLAALGERPATFLAADGLAGLEKQSLDVVLCNPPFHQQQVVGDFLAWRMFQQAREALVVGGALYIVGNRHLGYHSKLARLFRGVEQVAATPKFVILKARK
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRAD_ECO24
Sequence: MMRQSLQAVLPEISGNKTSPLRKSVCSDLLTLFNSPHSALPSLLVSGMPEWQVHNPSDKHLQSWYCRQLRSALLFHEPRIAALQVNLKEAYCHTLAISLEIMLYHDDESLTFDLVWDNGGWRSATLENVS
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraD.
What is the protein family that this protein belongs to?
Belongs to the GpW/Gp25 family. IraD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITSN2_HUMAN
Sequence: MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLL
What is the function of this protein?
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery.  May regulate the formation of clathrin-coated vesicles (CCPs).  Seems to be involved in CCPs maturation including invagination or budding.  Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).  Plays a role in dendrite formation by melanocytes (PubMed:23999003).
What are the official names of this protein?
Intersectin-2, SH3 domain-containing protein 1B, SH3P18, SH3P18-like WASP-associated protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BH125_ARATH
Sequence: MDCVPSLFMPDSTYEDGLLFSDSFLLSPFISYQNNDVFHSITNKIGGSNKKRSLCDITYGANEANKNDDDRESKKMKHRDIERQRRQEVSSLFKRLRTLLPFQYIQGKRSTSDHIVQAVNYIKDLQIKIKELNEKRNRVKKVISATTTTHSAIEECTSSLSSSAASTLSSSCSCVGDKHITVVVTPCLVGVEIIISCCLGRNKSCLSSVLQMLAQEQRFSVVSCLSARRQQRFMHTIVSQVEDGKQINILELKDKIMTM
What are the official names of this protein?
Transcription factor bHLH125, Basic helix-loop-helix protein 125, AtbHLH125, bHLH 125, Transcription factor EN 2, bHLH transcription factor bHLH125.
What are the subcellular locations of this protein?
Nucleus.
Protein: LY6D_MOUSE
Sequence: MKTALLVLLVLAVATSPAWALRCHVCTNSANCKNPQVCPSNFYFCKTVTSVEPLNGNLVRKECANSCTSDYSQQGHVSSGSEVTQCCQTDLCNERLVSAAPGHALLSSVTLGLATSLSLLTVMALCL
What is the function of this protein?
May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development.  Marks the earliest stage of B-cell specification.
What are the official names of this protein?
Lymphocyte antigen 6D, Ly-6D, Thymocyte B-cell antigen, ThB.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: LYRA_STAEQ
Sequence: MKNSRFSGFQWAMMVFVFFVITMALSVILRDFQATIGVKRFVFSIKDLAPFIAAIVCILVFKHRKEQLAGLKFSISLKVIERLLLALILPLIILMIGLFSFNTYADSFILLQTSDLSVSLLTILIGHILMAFVVEFGFRSYLQNILETRMNTFFASIVVGLIYSVFTANTTYGVEYAGYHFLYTFMFSMIIGELIRATNGRTIYIATAFHASMTFALVFLFSEETGDLFSMKVIALSTTIVGVSFIIISLIIRAIVYKTTKQSLDEVDPNNYLSHIQDEEPSQEDASSTSNHDVSSKDETKQQDIDNDKHQSKKPNKSDDALTTSNYKEDASSVNKETDTTHNDNIKDHSTYTEDRHSSVVNDVKDEIHEVEDHKADTDKSH
What are the official names of this protein?
Lysostaphin resistance protein A.
What is the protein family that this protein belongs to?
Belongs to the LyrA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SELO_YERPB
Sequence: MKPRMEYAPEFDNSYARQLSGFYTRLQPTPLKGARLLYHSKPLAQELGLDAHWFTEPKTAVWAGEALLPGMEPLAQVYSGHQFGMWAGQLGDGRGILLGEQRLNDGRYMDWHLKGAGLTPYSRMGDGRAVLRSVIREFLASEALHHLGIPTSRALTIVTSDHPIYREQTERGAMLLRVAESHIRFGHFEHFYYRQQPKQVQQLADYVIARHWPQWVGHQECYRLWFTDVVERTARLMAHWQTVGFAHGVMNTDNMSILGITMDYGPFGFLDDYVPGYICNHSDHQGRYAYDNQPAVALWNLHRLGHALSGLMSADQLQLALEAYEPALMVAYGEQMRAKLGFLERDSQDNDLLTGLLSLMIKEGRDYTRTFRLLSEVEVHSAQSPLRDDFIDRAAFDDWYRRYRSRLQQESIDDDQRQQSMKAANPKYILRNYLAQQAITQAEKDDIQPLQRLHQALQQPFTDQPEFDDLAALPPDWGKHLEISCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: AIS_ECOL5
Sequence: MLAFCRSSLKSKKYFIILLALAAIAGLGTHAAWSSNGLPRIDNKTLARLAQQHPVVVLFRHAERCDRSTNQCLSDKTGITVKGTQDARELGNAFSADIPDFNLYSSNTVRTIQSATWFSAGKKLTVDKRFLQCGNEIYSAIKDLQRKAPDKNIVIFTHNHCLTYIAKDKRDATFKPDYLDGLVMHVEKGKVYLDGEFVNH
What is the function of this protein?
Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core.
What are the official names of this protein?
Lipopolysaccharide core heptose(II)-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. Ais subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: TRMD_ACIC1
Sequence: MHVDIVSIFPEYFRPLELSLIGKARARGVLDVHLWDLRDFTHDPHRTVDDTPYGGGPGMVMRPEPWGETLDAVRAEAARLGVDAPLLIVPTPAGELLTQRAAERYAAEPWLAFACGRYEGIDERVLLDARRHMRVEEVSIGDYVLAGGEAATLVIVEAVARLLPGVVGNQASVLDDSHAQGLLEGPAYTKPAVWRGLEVPEVLLSGNHAAIARWRREQAIRRTAVRRPELLDALPPGSLTPHEEALAAEARLHAGRSAETPPPAGAAGSQAEGPPGTSPSDAAVAH
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_ALBFT
Sequence: MFASDVPRLTGWAPERWPVAADWRPVVDRFLTSETGRALERFVRARLAGGAVIYPQQPLRALALTPLAQVKVVILGQDPYHGPGQAEGLAFSVAPGVRPPPSLCNIFREIARDPLLSPGNLIPHGDGSLVAWARQGVLLLNSCLTVEEGQPASHAGRGWEALTDEVVKAVASIDNPVVFLLWGAHAQAKQRLIAATARQGGRAAADHLVLTANHPSPLSARRPPLPFLGCGHFGLANAYLLQHGCAPIAW
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAPSN_TETCF
Sequence: MGQDQTKQQIEKGLQLYQANETGKALEIWQQVVERSTELPGRFRALGCLITAHSEMGKYEDMLRFAVAQSEAARQMGDPERVTEAYLNLARGHEKLCEFSEAVAYCRTCLGAEGGPLRLQFNGQVCLSMGNAFLGLSAFQKALECFEKALRYAHGNDDKMLECRVCCSLGAFYVQLKDYEKALFFPCKSAELVADYGRGWSLKYKAMSRYHMAAAYRKLGRMDDAMECCEESMKIALQHQDRPLQALCLLCFADIHRHRSDIGKALPRYESSLNIMTEIGNRLGQAHVLLNIAKCWMTEKKLDKTLGVVQKAEELADAVGNKLVLLKAHCLYETIYREMGSDQLLRDHVVKFHECMEDMELYCGLCGESIGDQNSQLQALPCSHLFHLKCLQTNGNRGCPNCKRSSVKPGYV
What is the function of this protein?
Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction.  It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity).
What are the official names of this protein?
43 kDa receptor-associated protein of the synapse, RAPsyn, 43 kDa postsynaptic protein, Acetylcholine receptor-associated 43 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the RAPsyn family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic surface of postsynaptic membranes.
Protein: MA8J_SCHJA
Sequence: MCVCRVDILSRFDIALSLLQSLTHSHTVLRHLCFLPTIIYKHLCEFTISFSSPVISTGQHIDVGDEDYHDGDDDVDYTDDVDDVDDPHGSPSQLLQGGYQRNQHYGGGNYQSGYYRPNKQHGNGYGGQYPKKYGSGYKH
What are the official names of this protein?
Immunogenic miracidial antigen 8I'.
What is the protein family that this protein belongs to?
Belongs to the immunogenic miracidial antigen family.
Protein: RUVB_STRPN
Sequence: MSRILDNEMMGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEAAKMRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNDLEPGDVLFIDEIHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTRAGMLSNPLRARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPRIANRLLKRVRDFAQIMGNGVIDDVITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGGPVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: HRCA_STAAN
Sequence: MITDRQLSILNAIVEDYVDFGQPVGSKTLIERHNLNVSPATIRNEMKQLEDLNYIEKTHSSSGRSPSQLGFRYYVNRLLEQTSHQKTNKLRRLNQLLVENQYDVSSALTYFADELSNISQYTTLVVHPNHKQDIINNVHLIRANPNLVIMVIVFSSGHVEHVHLASDIPFSNDKLNTISNFVTNKLTEFNQNLQDDIVSFVQSEQEEIFINKLINTMNNHISNQSNSIYMGGKVKLIDALNESNVSSIQPILQYIESNRIAELLQDISSPNINVKIGNEIDDSLSDISIVTSQYHFDETLKGQIAVIGPTAMHYQNVIQLLNRIW
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: GUAA_ALKMQ
Sequence: MKQELVLILDFGGQYNQLIARRVREHNIYCEVVPYKITAEEIKLKNPKGLILTGGPSSVYGESTPRCEEEIFQLDIPILGICYGGQLMAHTLGGKVNRAKNREYGKTALQVDGNSKLFKEVAQDSICWMSHTDFIETAPAGFKITGTTADCPVAAMENQEKALYAVQFHPEVEHTEKGKEILKNFLYEVCHCQGDWTMENYIEKEIEAIRNLVGDRKVLCALSGGVDSSVAAVLVHQAIGDNLTCVFVDHGLLRKDEGDWVEDIFRNQFEMNFIRVNAEERFLGKLKGVTDPELKRKAIGELFIRVFEEEAQKIGDFDFLVQGTLYPDIIESGTETAAVIKSHHNVGGLPEDMKFQLIEPFKFLFKDEVRIAGLELGVPEEIVWRQPFPGPGLAVRVLGEITEEKLHIVREADAIVRDEIIKAGLHRQIWQYFAVLPNIMSVGVMGDERTYAHTIGIRAITSSDAMTADWARIPFEVLENMSRRIVNEVEGANRIVYDITSKPPSTVEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PAFA_STRCO
Sequence: MDRRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDNVTELVTHDKAGERILEGLLVDAERRLHEEGIAGDVYLFKNNTDSAGNSYGCHENYLVARHGEFSRLADILIPFLVTRQLLCGAGKVLQTPRGAVYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTMLLKVGATDLVLRMIEAGTVMRDLTLENPIRAIREVSHDITGRRKVRLASGREASALEVQREYYEKAVDFCERRGIRTGTVERVLELWGRTLDAIEAEDLDRIGTEIDWVMKYKLLERYRAKHNMTMSHPRVAQIDLAYHDIHRRRGLYYLLEKKGQAARVANDLKIFEGKSVPPQTTRARLRGDFIRRAQEQRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVEKLIAGM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: PLK4_DROWI
Sequence: MLPVRNYGETIEEYEVQHLLGKGGFASVYKARCRRTYQDVAIKMIDKKLIHGTGLSSRVRQEVEIHSRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNQQMSHPFTEADAATILQQVVAGLLYLHSHNIMHRDISLSNLLLSKDMHVKIADFGLATQLKRPDEKHMTMCGTPNFISPEVVSRLSHGLAADVWSVGCLLYTLVVGRPPFDTDAVQSTLNKVVMSEFIMPTHLSFEACDLIEKLLKKNPHERISLEQVLRHPFMSKRSAGAEEPQYNSSKPGACDFYMEAQGQSVASGDSGIVTFASNESRSSQRLRSIEKSAQSSSNPQMLPQIQEEYGYWQPSTEHKPYPMPLSSDNAEWERLGSKGNQPHTAASVITEEQQMRVPPLNTIRLQPTRYKTKNAIMSILRHGEVVLEFVKFRSKLNEDRVTDICRISGDGRRIIIYQPDPGRGLPIREQPPPPESHIAGDKSVYNYDSLPSKHWKKYLYAARFVGLVKSKTPKITYFSSLAKCHLMENMIDFEMSYYSGAKYVKTSPGEELKLYNNYGMLLSDLACPEAKKMIEHGNECFSHCINICNALELAQQSADSRNTCFPVTIGRRPLTDVSHSQRFDGLRDTTNIAYSTPKSHQGSINFSMSTISSVQNGSESVSSTHSHASRAQIQASQQNVPIKRINIPDVGIATELSHGIVQVQFYDGSMISLIPEIQGGGLTYTQCNGVSTYFPKYDGDLPLAVRDRLAQIPQVKLRLKCAPLLSNHRKADNIAMTPKSTTPSTPCYNRIVL
What is the function of this protein?
Serine/threonine-protein kinase that plays a central role in centriole duplication.  Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6.  When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.  Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK4, Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase SAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: RL23_BURCH
Sequence: MSEIRKNDHRLMQVLLAPVISEKATLVADKNEQVVFEVAPDATKQEVKAAVELLFKVEVDSVNVLVQKGKQKRFGRSMGRRKDVKKAYVCLKPGQEINFEAEAK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: LEUD_SACEN
Sequence: MEPFKTHTGVGVPLRRSNVDTDQIIPAVYLKRVSRTGFEDALFAAWRADDDFILNNPHFRNGSVLVAGPDFGTGSSREHAVWALKDYGFRVVISSRFADIFRGNSGKQGLLAARCEQSDVELLWKVLETEPGTSVTVDLEARTVHAKDLTVPFEIDDYTRWRLLEGLDDIGLTLRQAETIDTFEKTRPSFKPATLPARAG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: Y2492_SHEFN
Sequence: MAIQSKYTNTQVEALISELLAVLAKHQAPTDLSLMVLGNCVTHLLDKKVPGESRQKVAEQFAKALTQSVK
What are the official names of this protein?
UPF0352 protein Sfri_2492.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: RS19_METPP
Sequence: MARSLKKGPFVDHHLVAKVEKAVAIKDKKPIKTWSRRSTILPDFIGLTIAVHNGKQHVPVYVTDQMVGHKLGEFALTRTFKGHPADKKAKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: Y4343_BACHK
Sequence: MKVSYHGHSVVKIETNGKVILIDPFLTGNPKTDLKAEDVKVDAILLSHGHGDHVGDTVELAKKNNAVVVAPFELATFLSWQGVNTHPMHIGGSHEFDFGKVKFTQAFHGSSYIDEENKTITYTGMPAGILVTAEEKTLYHAGDTALFSDMKLIGELNNIDVAFLPIGDNFTMGPEDAVLAAKWVQAKTVVPMHYNTFPVIEQDPYQFVEKLQNCTGKVLEAGESITL
What are the official names of this protein?
UPF0173 metal-dependent hydrolase BT9727_4343.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: NUD22_HUMAN
Sequence: MDPEVTLLLQCPGGGLPQEQIQAELSPAHDRRPLPGGDEAITAIWETRLKAQPWLFDAPKFRLHSATLAPIGSRGPQLLLRLGLTSYRDFLGTNWSSSAAWLRQQGATDWGDTQAYLADPLGVGAALATADDFLVFLRRSRQVAEAPGLVDVPGGHPEPQALCPGGSPQHQDLAGQLVVHELFSSVLQEICDEVNLPLLTLSQPLLLGIARNETSAGRASAEFYVQCSLTSEQVRKHYLSGGPEAHESTGIFFVETQNVQRLLETEMWAELCPSAKGAIILYNRVQGSPTGAALGSPALLPPL
What is the function of this protein?
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP.  Preferred substrate is UDP-glucose.
What are the official names of this protein?
Uridine diphosphate glucose pyrophosphatase NUDT22, UDPG pyrophosphatase, UGPPase, Nucleoside diphosphate-linked moiety X motif 22, Nudix motif 22.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.