PharMolix/UniProtQA huggingface dataset:
Protein: KITH_HHV1S
Sequence: MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMIQTHVTTPGSIPTICDLARTFAREMGEAN
What is the function of this protein?
Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis.  The dTMP serves as a substrate for DNA polymerase during viral DNA replication.  Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae thymidine kinase family.
Protein: LSPA_CAUVC
Sequence: MPSLSITRQGWIAYAIAAVTVVLDQISKLWILGLLGREPGASLPLLGPIHLTMVHNYGMSFGLLRDSDWGRWLLIGFSILVVIGLAVWVHKATRPLLAVGIGLIIGGAIGNNLIDRVIYGYVVDFIDVSRLYFPWVFNIADSGISVGVALLLLDSFLSEENKLSHQTE
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PUR2_CORGL
Sequence: MRILVIGSGAREHALLRGLSTDPATTELHVAPGNAGLGSIATVHPGIKADDPEAVTALAKELNSDLVVIGPEIPLVAGVADALRAAGIAVFGPNKDAARIEGSKAFAKDVMAAQGVRTAHAEAITPGASSEDIDAAIDRFGPTWVVKDDGLAAGKGVVVTPDRAAARAHVDAVLEGGNPVLLESFLDGPEVSLFCLVDGETVVPLLPAQDHKRAYDNDEGPNTGGMGAYAPLPWLPEDGVQRIVDEVCVPVAREMVARGCAYSGLLYAGIAWGAEGPAVVEFNCRFGDPETQAVLALLKTPLAVLLNAVATGTLAEQPALEWEDAYALTVVLASYNYPEAPRTGDVIRNADADNVLHAGTALNAEGELVSAGGRVLNVIGVGETLEAARDNAYTTIKDIELEGSHYRSDIALAALEGRISI
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: RGS5_MOUSE
Sequence: MCKGLAALPHSCLERAKEIKIKLGILLQKPDSAVDLVIPYNEKPEKPAKAHKPSLEEVLQWRQSLDKLLQNSYGFASFKSFLKSEFSEENLEFWVACENYKKIKSPIKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSPRSFDLAQKRIYALMEKDSLPRFVRSEFYKELIK
What is the function of this protein?
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.  Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
What are the official names of this protein?
Regulator of G-protein signaling 5, RGS5.
What are the subcellular locations of this protein?
Cytoplasm. Membrane.
Protein: AB2E_ARATH
Sequence: MADRLTRIAIVSSDRCKPKKCRQECKKSCPVVKTGKLCIEVTVGSKLAFISEELCIGCGICVKKCPFEAIQIINLPRDLEKDTTHRYGANTFKLHRLPVPRPGQVLGLVGTNGIGKSTALKILAGKLKPNLGRFTSPPDWQEILTHFRGSELQNYFTRILEDNLKAIIKPQYVDHIPRAVKGNVGEVLDQKDERDKKAELCADLELNQVIDRDVENLSGGELQRFAIAVVAIQNAEIYMFDEPSSYLDVKQRLKAAQVVRSLLRPNSYVIVVEHDLSVLDYLSDFICCLYGKPGAYGVVTLPFSVREGINIFLAGFVPTENLRFRDESLTFKVAETPQESAEEIQSYARYKYPTMTKTQGNFRLRVSEGEFTDSQIIVMLGENGTGKTTFIRMLAGLLKPDDTEGPDREIPEFNVSYKPQKISPKFQNSVRHLLHQKIRDSYMHPQFMSDVMKPLQIEQLMDQEVVNLSGGELQRVALTLCLGKPADIYLIDEPSAYLDSEQRIVASKVIKRFILHAKKTAFVVEHDFIMATYLADRVIVYEGQPSIDCTANCPQSLLSGMNLFLSHLNITFRRDPTNFRPRINKLESTKDREQKSAGSYYYLDD
What are the official names of this protein?
ABC transporter E family member 2, ABC transporter ABCE.2, AtABCE2, RNase L inhibitor-like protein 2, AtRLI2, AthaRLI2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCE family.
What are the subcellular locations of this protein?
Membrane.
Protein: IDD5_ARATH
Sequence: MAASSSSAASFFGVRQDDQSHLLPPNSSAAAPPPPPPHHQAPLPPLEAPPQKKKRNQPRTPNSDAEVIALSPKTLMATNRFICEVCNKGFQREQNLQLHRRGHNLPWKLKQKSTKEVKRKVYLCPEPSCVHHDPSRALGDLTGIKKHYYRKHGEKKWKCDKCSKRYAVQSDWKAHSKTCGTKEYRCDCGTLFSRRDSFITHRAFCDALAQESARHPTSLTSLPSHHFPYGQNTNNSNNNASSMILGLSHMGAPQNLDHQPGDVLRLGSGGGGGGAASRSSSDLIAANASGYFMQEQNPSFHDQQDHHHHHQQGFLAGNNNIKQSPMSFQQNLMQFSHDNHNSAPSNVFNLSFLSGNNGVTSATSNPNAAAAAAVSSGNLMISNHYDGENAVGGGGEGSTGLFPNNLMSSADRISSGSVPSLFSSSMQSPNSAPHMSATALLQKAAQMGSTSSNNNNGSNTNNNNNASSILRSFGSGIYGENESNLQDLMNSFSNPGATGNVNGVDSPFGSYGGVNKGLSADKQSMTRDFLGVGQIVKSMSGSGGFQQQQQQQQQQQQQQQHGNSRERVGSSSDSADRSSMNVNTGGGPASTSPPYGIHHASF
What is the function of this protein?
Transcription factor acting as a positive regulator of the starch synthase SS4.  Controls chloroplast development and starch granule formation (PubMed:22898356).  Binds DNA via its zinc fingers (PubMed:24821766).  Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766).
What are the official names of this protein?
Protein indeterminate-domain 5, chloroplastic, ID1-like zinc finger protein 2.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YFAS1_YEAST
Sequence: MIFNLPVSVLLYFSLIWAMEPSFVRGKNVVNLITFKDSNGKLHKRLAPEEIPPRLHNSQVNSYPLGYKGMRDFSRPAVNLDDILGTQQRKQQEFLAELSPLSLESKLSLVNEVQIFASYVRNDVETYNKVSDPNEDLIIIAPTNRAVSQLTLKPWQFPNNIDKLESDGATEKELDTAIQENISKFVRSHIVVYNDDKNSYKKVSPGCTLLQSIDFTESKKSDSETGGDILLKKEGEVYYVASSRDEKFHAVESIENGSNGVILMVDFTLVGP
What are the official names of this protein?
FAS1 domain-containing protein YDR262W.
What are the subcellular locations of this protein?
Vacuole.
Protein: ATPF_GEOUR
Sequence: MTSTRKSVLTSSSTITVTTCLLLVGLAAAGYASEGGEGAHHVDTAKQMKDFAWRCLDFAVLLAIVVWALKKANVKGSLAERQSNIEKMLKEAVEAKEQAEKKFLEYNEKLEQANKEIEAMSAAMKQEGELEKVRIIAEAKAAAEKVKEQAQQAAHQEILKARIELRDEAARLAVEIAEKKIKENITKNDQDKLVGDYISKVVTLH
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PTH_MESH2
Sequence: MKLIVGLGNPGEKYAKTKHNVGYWVLDLLAEKLALSFDQKTENGIYVKQPDFILAKPTTFMNKSGDFVEELIKFYKINTQDLMIIYDDMNFEVGQAAIKTTGSAGGQRGMAHIIEKCKTKEIKRLKIGISRGENAKEYVLSPFLPKDNAKIKLVIEEAANILIFYLSNSFITTIEKFNANKNKV
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIFM1_HUMAN
Sequence: MFRCGGLAAGALKQKLVPLVRTVCVRSPRQRNRLPGNLFQRWHVPLELQMTRQMASSGASGGKIDNSVLVLIVGLSTVGAGAYAYKTMKEDEKRYNERISGLGLTPEQKQKKAALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED
What is the function of this protein?
Pro-apoptotic isoform.
What are the official names of this protein?
Apoptosis-inducing factor 1, mitochondrial, Programmed cell death protein 8.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969). SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion intermembrane space. Mitochondrion inner membrane. Note=Has a stronger membrane anchorage than isoform 1. SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion. Cytoplasm, cytosol. Note=In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm.
Protein: ALLA_AGRFC
Sequence: MTDFLEIRPLTKEAFTPFGDVIETTPSSMRHINGGQTERHHALSAPEAAGEGARIILNIFRGQPRVFPHKIDMMERHPLGSQSFSPLSGRPFLVVVAQDDGGRPARPQVFLARGDQGVNYRRNVWHYPLMPLQAVSDFLVADREGPGNNLEEYFFDEPFMIAEPSL
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: KCY_PSEPK
Sequence: MNSMAPVITIDGPSGSGKGTVAGLIARELGWKLLDSGALYRLLAFNASNHGVDLTNEELLTKLAAHLDVQFIAAEPGKLQQIILEGEDVSNVIRTETVGAGASMVASLPAVRDALLVRQREFREVPGLIADGRDMGTVVFPDAPLKVFLTASAEERARRRYLQLKGKGEDVSLSSLLDEIRARDERDTQRAVAPLKPAADAIQLDSTELSIEQVLQRIRSEIAQRDLI
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_BORDL
Sequence: MFNIIKNDKNSNARLGILELPHGNVATPCFMPVGTLGVMKALKHDVLEKLGCDLMLANTYHLYLRPGIDVIKKYGNLHNFTTWNKNFLTDSGGFQVFSLSNFRKIEDEGVDFKSHIDGSRHYFTPESVFSMQETFESDIIMALDICSPYGIDYDEASLYTNITTSWARRTLCAYKNRKEGYEGLLFLITQGNFFKDLRKRSTESILELNSPGIAIGGISVGEPRDRYLEILEYNSSLIPKDKPKYVMGIGTPHYILDAIYNGIDIFDCVNPTRIARHGSLLTDNGILRINRAEFRFDTCSVERECSCTLCTRYSRGYLRHLFKSEEALGVMLASEHNIHYMFRLINKAKNAIMNDNFVKFRKLYLDKYDEGNLNE
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: LCP52_DROME
Sequence: MKFLIVFVALFAMAVARPNLAEIVRQVSDVEPEKWSSDVETSDGTSIKQEGVLKNAGTDNEAAVVHGSFTWVDEKTGEKFTITYVADENGYQPQGAHLPVAPVA
What is the function of this protein?
Component of the cuticle of the larva.
What are the official names of this protein?
Larval cuticle protein 65Ab2, Larval cuticle protein 5.
Protein: WTPA_METJA
Sequence: MIKRLIVISILLIVGTVLCGCMEQENVGQQNSEAQEKIVLKIFHAGSLSVPFEEYEKMFEKEHPNVDVEREPAGSVACVRKIIDLGKKADILASADYSLIPQMMMPKYADWYVMFARNEIVLAYTDKSKYKDEINSTNWYKILQRPDVKIGFSNPNDDPCGYRTQMVLQLAELYYKDPTIYDNLVLKHSNIKVEENNGTYLILVPKELDVDTNKLFVRSKETDLLAPLEAGAFDYLFIYKSVANQHHLKYIELPKEINLGYYEYADTYKKVALKIIAKNKTINAKPIVYGMTVPTNAPHKKEAIEFVKFVLGHPEVLENNGQPAIIPAVAYGNVPEELKDLVKIEK
What is the function of this protein?
Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import.  Binds tungstate and molybdate (By similarity).
What are the official names of this protein?
Molybdate/tungstate-binding protein WtpA.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MDCC_STRM5
Sequence: METLDYRFDGTTHAHFPTNAVLVGVLASGNLEILLEPAALDGAMTVRIITAAQGFGSVWQAVITDFARRHPLRDVRISINDAGATPAVVSLRLDQAVETLLGGGTP
What is the function of this protein?
Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.
What are the official names of this protein?
Malonate decarboxylase acyl carrier protein, Malonate decarboxylase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the MdcC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRAS_STAEQ
Sequence: MNNFRWFWFFIKSRINWILWILFLNIILLGVAYIDYEISVESVFYIVILNVGLSILFLLFTFVKEVRLSKHFYEDKEIEEIKHKDLAETPFQQQVIDYLYRHIAAQKEKVVEQQLQIKNHEQTITEFVHDIKTPVTAMKLLIDQENDDQRKRALLFEWSRINEMLDKQLYLTRLETHHRDMYFDYISLKRMVIDEIQVTRHISQAKGIGFELDFKDEQKVYTDVKWCRMMIRQVLSNSLKYSDNSTINLSGYNIEGHVVLKIKDYGRGISKRDLPRIFDRGFTSTTDRNDTASSGMGLYLVQSVKEQLGIEVKVDSIVGKGTTFYFIFPQQNEIIERMSKVTRLSF
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).  GraS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to GraR (By similarity).
What are the official names of this protein?
Sensor histidine kinase GraS, Glycopeptide resistance-associated protein S.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLMB_HAEDU
Sequence: MSEQIYGIHAVNAFLANAPERLIEVFVLKGREDKRLNPLLDELQRLSISVQQVNRQTLDNKAQGEVHQGIIARIIPQKELNEYDLNELLQHKSNPLLLILDGVTDPHNLGACLRTADAAGVDAVIVPKDKSATLTAIARKVACGAAEAMPLIRVTNLARTMRELQDKHQIWIVGTAGEATTDIYTSQLTGAIALVMGAEGDGMRRLTREHCDQLVSIPMAGSVSSLNVSVATGVCLFEIVRQKLSR
What is the function of this protein?
Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
What are the official names of this protein?
23S rRNA (guanosine-2'-O-)-methyltransferase RlmB, 23S rRNA (guanosine2251 2'-O)-methyltransferase, 23S rRNA Gm2251 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR_FRATH
Sequence: MNILKISKQTLRNNIKIIREYIGNAKMCFPVKANAYGHGIEDIVENTHDLVDFFAVANSLEAFRVTAVAKNPVLVFGVIYYEYIEKMISENIRVSIQDYEYIEKLEQIAKELDKKVYAHININTGMNRMGVDYNDACRTIQRAYESDWLILEGVYSHLACADNRDHPTNIKQKNRFDSIVKFTKGLSQDIICHLSNSYGFLGQKGICYDMVRPGILSYGFLPEFYVDRVIREIKPIARLLSKVVKIITLQEGEGVGYSLIYRGFEGEQLAVIPIGYGDGFPRELGDRGFVNINDVMYPMAGRMSMDGLTVSLGINEYDVKVGDTVELISAIPRNRNSAFSIAKQTNTIEYDIMSTLNDRIIRKII
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: DCUP_GLOC7
Sequence: MSQSAEIPYLLRAARGEVLDRPPVWMMRQAGRYMKVYRDLRDKYPSFRERSENADLAIEISLQPWRAFQPDGVIMFSDILTPLPGIGIPFDIIESKGPIIDPPIRTQQQIDHLHPFDPDQTVPFVKTILKTLRQEVGNQSTVLGFVGAPWTLAAYAVEGKSSKTYSIIKSMAFSEPAILHQLLSKLADMVASYVRYQIDCGAQVVQMFDSWAGQLTPQDYDVFALPYQQQVVRQVKETHPDTPLILYISGSAGVLERMGKSGVDMISVDWTVDMAEARQRLGKEMKVQGNIDPGVLFGSQSFIRDRIVDTIRKAGNQGHILNLGHGVLVGTPEDNVRFFFETAKNADQLLVHA
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_NITEC
Sequence: MNKSRVVVGMSGGVDSSVAALLLKQQGYDVIGLFMKNWEDDDTDEYCSSRKDFLDAASVADILDIPLEAVNFSAEYRERVFSLFLAEYQAGRTPNPDVLCNSEIKFKAFLDHALALGADWIATGHYAQVHEINGQFQLLKGEDGNKDQSYFLYRLNQQQLSRTIFPIGHLYKREVRKIAHKHGLPNSTKKDSTGICFIGERPFREFLNRYLPVDPGEIHTLDGQIVGEHQGLMYYTIGQRQGLGIGGIREGSEQPWFVSGKDMQTNVLYVVQGHDHPALLRSSLTAADLSWISGAPPHQSWVYAAKIRYRQTDAPCAIIRLEHDSCQIGFAAPQWGVTPGQSVVIYESKVCLGGGIITDSV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_WIGBR
Sequence: MMNDYKNTLNLPKTKFPMKANLLISELKILECWKKNNLYSIIRENKKGKKTFFLHDGPPYANGDIHIGHAVNKILKDIIIKFKSLFGFDAPYMPGWDCHGLPIELQVEKKINQNINKINHKIFREKCRNYALDQVNKQKKEFIRLGVIGDWNNPYLTMDFHTEANILRTFKNLIKKKYLYRGIKPINWCIDCKSSLSDSEIDYNIKESNSIDVSFSACDNNKILKIFNSEKKFDKIKAIIWTTTPWTIIANRAISVNPNFIYLLVKCNKEIFIIAESLLDKTLARLNIKKSKILGSVYGKKLKFLYFKHPLNKIHVPMILNEYVDFKSGSGIVHVAPNYGEEDYIIGKKYKLNMYDPIDSNGNYLPGTFPGLDGLNIFKSEEVVLNLLKNNHSLYSKKIINHSYPHCWRHKSPTFFRATNQWFFNIDNNNLRNKTISEIKKILWIPKWGMNQIIDLLSNRPDWCISRQRVWGVPIAVFINKKNKEIHPNTVELIEKVSKKIEKKGVQAWWDINKSEILDKDSDKYKKVLDTLDVWFDSGSTYYSILIKKWNSLNKNKVDLYLEGSDQYRGWFMSSIILSIAITGGIPCKKILAHGFVVDSNGKKMSKSIGNVISPKDIINEFGADILRLWVASSDYKSDISISKEILLRTVDIYRRIRNTSRFLLSNLNDFNPEFNSINLENMLSIDQWAIIKTNNRQKKIKNAYEEYNFHKVVSNIVDFCSLDMGSFYLDIIKDRQYTNYIDSLARRSCQTAILYIIECLVRWIMPILSFTSHEIWKYIPGKREKYVFLSEWVKEIPCENINSYISKSLWKILIKIKNEINKIIEIKKLEDKIKSSLELKITLYAESFIFEELILLKKELNFAFLVSYVSIKKYENSKENAFKSKSIKNLKILAEKFDGKKCLRCWNYTNDIVNDVKYNKICNRCINNINGVEEKRKYF
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_METMA
Sequence: MEKKSLLILGTASHVGKSSVVTAICRILSRSYRVAPFKAQNMSLNSWITKDGKEIGIAQAIQAKAAGTEPTADMNPVLLKPKGDCVSQVVLLGEPYADKSAGQYYDSIEEMHAVLKGALERLWKEHDIIVMEGAGGAAEINLYERDIVNVGTARLTKAPIILVGDIERGGVFASLYGTIALLPEDVRKNVKGFIINKFRGDIEILRPGLKQLEDKTGIPVLGVLPHFKLRIPSEDSVSLGDKEDSKAEKEIEVAVIRLPRISNFTDFEPLEGLVKVRYVDINEELGNPDAIMIPGTKNTVNDLLDLRASGMDKKIQAFKGKVPIFGICGGYQMLGRTIFDSGVENGVEAEFEGLGLLDIGTRFGEYKKRTVQVTKKVNGYGPILRPIDGEEIKGYEIHMGVTDSNRTVFGDDGAIDEDGFVIGTYLHGLFDNRNIRNALVRYLYEKKGLEYEPDEAISENDAYEELANVVEQNIDMEKLFEIAGV
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Probable cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: WLS_DROGR
Sequence: MSGTILENLSGRKLSILVSSLMLCQVVCFLMGGLFAPVPAGHQTVLGSKCRDVPGRQNDTSFFLYSRGNGACKSLQDIDIEQDELKMANQLVYVFQMPLPRDNNTLQYSRWQQNLIGVLQVDIAYDSASELREPPKELQLTIDTRLAYRNQKDADTDWKLYAHSVEQRYLDCHASHVGRLETLYTCDIIPLFELGALHHNFYLLNLRFPMDTPKQMNLQFGHMHDLTLTAIHQNGGFTQVWLVLKTLLFPFVIGIMMWFWRRVHILQRSPALLEYMLFYLGGALSFLNLPLELLTLGVEMPYMLLLSDVRQGIFYAMLLSFWLVFAGEHMLIQDSPSKSTIRSRYWKHLSAVVVGCISLFVFDICERGVQMRNPFYSIWTTPLGAKVAMSFIVLAGVSAAIYFLFLCFMVWKVFKDIGDKRTSLPSMSQARRLHYEGLIYRFKFLMLATLLCAGLTVAGFIMGQMAEGHWKWNENIEIQLTSAFLTGVYGMWNIYIFALIILYAPSHKQWPTMRHSDETTQSNENIVASAASEEIEFSNLPSDSNPSEISSLTSFTRKVAFD
What is the function of this protein?
A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells.  In non-neuronal cells wls directs wg secretion.  The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26).  In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles.  Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip (By similarity).
What are the official names of this protein?
Protein wntless.
What is the protein family that this protein belongs to?
Belongs to the wntless family.
What are the subcellular locations of this protein?
Presynaptic cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=In non-neuronal cells, wls binds to wg in the Golgi and accompanies it to the plasma membrane where the two proteins dissociate. Wg is secreted and wls is then internalized and returns to the Golgi apparatus in a retromer-dependent manner. Wls and wg colocalize in the Golgi apparatus in wg-producing cells, and reduced expression is seen in non-producing cells. Endoplasmic reticulum expression is unchanged in wg-producing versus non-producing cells. In neuronal cells, wls is localized both pre- and postsynaptically and is transferred trans-synaptically from the pre- to the postsynaptic compartment (By similarity).
Protein: RS11_CHLFF
Sequence: MVKHQTQKKGVKRKQLKNIPSGVVHVKATFNNTIVSITDPAGNVISWASAGKVGYSGSRKSSAFAATVAAQDAAKNAMNSGLKEVEVCLKGTGAGRESAVRALIAAGLVVSVIRDETPVPHNGCRPRKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: NUOA_MYCBO
Sequence: MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECGIEPASTGARTSIGPGAASGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSYDSLGTFALVEMAIFMLTVFVAYAYVWRRGGLTWD
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.