PharMolix/UniProtQA huggingface dataset:
Protein: HIS1_LEPBL
Sequence: MLTLALPKGRLAEESIDLMISKGWLSAKPDPDSKELIYNDPLGKIRILLVRSQDVATYVEQCAADAGISGWDVLKEGGYDLATPLDLGIGKCRLSLAAPEGYTLEARHRKIRVATKYPNLAREFFFHKGLSCEIFKLYGSIELAPLVGLSDCIVDLVSTGGTLKANGLKELNIILESSARLVFNRSSLYGKRKEAAEFMDSLSKI
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHP_HAEIN
Sequence: MTTQFKPELLSPAGSLKNMRYAFAYGADAVYAGQPRYSLRVRNNEFNHANLKIGIDEAHSLGKKFYVVVNIAPHNSKLKTFIKDLQPVIDMKPDALIMSDPGLIMLVRENFPNIDIHLSVQANAVNWATVKFWKQMGLTRVILSRELSIDEIAEIRQQVPDIELEIFVHGALCMAYSGRCLLSGYINKRDPNQGTCTNACRWEYKMEEGTTDDVGNIVPKIDPAQQIEVKNVAPTLGEGAVTDKVFLYTESQKPDEQMTAFEDKHGTYFMNSKDLRAVQHVEKLTALGVHSLKIEGRTKSFYYCARTAQVYRKAIDDAAAGKPFDESLMDTLESLAHRGYTEGFLRRHTHDEYQNYEYGYSISDRQQFVGEFTGKRNEQGMAEVAVKNKFLLGDNVEMMTPQGNINFKIEKMLNRKNETVDAALGDGHFVFLNVPQDINLNYALLMRNLVNTNTRNPHSN
What is the function of this protein?
Involved in prephenate-dependent formation of 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis.
What are the official names of this protein?
tRNA hydroxylation protein P.
What is the protein family that this protein belongs to?
Belongs to the peptidase U32 family.
Protein: TCF21_XENTR
Sequence: MSTGSLSDVEDFQEVEMLECDGIKLDPNKEFGISNDSNEESSTCDNGSPKKGRGTSGKRRKAPSKKSPLGNINQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPENDLKEVVSTSRLCGPTAS
What is the function of this protein?
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis.
What are the official names of this protein?
Transcription factor 21, TCF-21, Capsulin, Epicardin, Podocyte-expressed 1, Pod 1, Pod-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFTS_VIBC3
Sequence: MAVTAALVKELRERTGAGMMECKKALVETNGDIELAIENMRKSGAAKAAKKAGNIAAEGTIMIKEGEGIAALVEVNCQTDFVAKDSNFVAFANQVTDAALASKASVEELQAQFEEARVALVAKIGENINIRRVQYVEGEALATYRHGDRIGVVVAGSADVETLKHVAMHVAASRPEFLTPDDVPAEVVAKEREVQVGIAMNEGKSKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPKKTVGEILAEKGATVSAFIRLEVGEGIEKQEGLSFAEEVALAQKG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC1_DEIRA
Sequence: MTTGAPPFSGSSPQTTRPQTVAEKILSQRGSAAVYAGDLAVVEVDQVMVVDSIAQSFIERMERDLGAVPKYPERVSIVVDHVAPASTVSVAQAQKEAREYAAKTGVRLFDVGRGICHQVLMEEKLAQPGWIVLGSDSHSTTYGAVAAFGSGMGATDIALAAASGKTWLRVPESVKVTLTGDLRPGVTAKDVALEMIRVLGADGATYQSVEIHAGDRFTRGERMTLANLCVEAGAKAGLVVPGGEILTDYGYDVPAWVYPDEGAAYAREVEIDLSALHPRMSAPSEVDNVHDVAELRGLKVDQVFIGTCTNGRIEDLHAAAEVLRGRRVDPTTRLLVIPASSQVMEEALQDGTLLTLQRAGAVLGTPGCGPCMGRHQGVLAPGEVCVSTSNRNFIGRMGDKDAHIYLASPAVAAATAVMGRVALPEDVAQVAASA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit 1, Alpha-IPM isomerase 1, IPMI 1, Isopropylmalate isomerase 1.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: TACY_STRP1
Sequence: MSNKKTFKKYSRVAGLLTAALIIGNLVTANAESNKQNTASTETTTTNEQPKPESSELTTEKAGQKTDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDKKKSEEDHTEEINDKIYSLNYNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAALQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDKATVEVNDPTYANVSTAIDNLVNQWHDNYSGGNTLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIAAYKQIFYTVSANLPNNPADVFDKSVTFKELQRKGVSNEAPPLFVSNVAYGRTVFVKLETSSKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGGDAAEHNKVVTKDFDVIRNVIKDNATFSRKNPAYPISYTSVFLKNNKIAGVNNRTEYVETTSTEYTSGKINLSHQGAYVAQYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes.  After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Can be reversibly inactivated by oxidation.
What are the official names of this protein?
Streptolysin O, SLO, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Probably secreted as soluble protein by the accessory Sec system (By similarity). It then inserts into the host cell membrane and forms pores formed by transmembrane beta-strands (By similarity).
Protein: RK22_EUGGR
Sequence: MEQKKPLESSASIKYVRISPFKVRRILNQIKGRSAKEALMILKFMPYKPSTLIFKLLKSAVSNSIKNYDEDANVLRVLEARADAGPILKRLCPHAQGRGFPIKKRTCHITIKLSIL
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL9_BORBU
Sequence: MKVILKEDFINLGKEGDTVEVRDGFARNYLLPKGFAVFSNKHNIEIFNQKRRSILKKQEAKKQMANDLKSKLDLVKLEFFMKSNDSGKLFHSINSLNIADELLKLGFDIERKKIDIHHGTLKTFGTYDVTIKLYEGISSIIKVEIKKEKKQEDKKSLSKKLNKADEQGERAEV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: PURL_STAHJ
Sequence: MSKFIEPSIEEIKLEKLYQDMGLSDAEYNKVCEILGREPNFTEVGIFSVMWSEHCSYKHSKPFLKQFPTTGEHVLMGPGEGAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSLRFGELSVKQNQRLLKGVVRGIGGYGNCIGIPTTAGEIEFDDRYDGNPLVNAMCVGVIDHDMIQKGTAKGEGNSVIYVGLKTGRDGIHGATFASEELTEESESKRPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLELHLDQVPTREPGISPYEMMLSETQERMLLVVEKGTEQKFLDLFEKHELDSAVIGEVTNTDRFVLKYEDEVFADIPVQSLADEAPVYVLEGEEKEYNTSKNDYSSINVEETFKKLLIHPTIASKHYLYEQYDQQVGANTIIKPGLQSSVVRVEGTNKAVASTIDGEARYVFNQPYEGGKMVVAEAYRNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMSEACEVLKTPVVSGNVSLYNETRGTSIFPTPVVGMVGLIEDIDYLKDFHPEAGHKLYLVGETRDDFGGSQVEKLLYGKVNHEFEAIDLSDEVNKGEAVKNTIRSGVASHVQTVGKGGLLITLARISAHYGLGLEASIDLSDAQLFSETQGRYIIVVKEGQTLNIDEAIEIGQLTDVDEFKVTNAQSSIVEKVSEIKESWEGAIAQCLTTVD
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOBA_ACIBC
Sequence: MNKGYPITDLVILAGGQARRMNGLNKLLQQFDGDTQLLKIHQKLKSSVSEIWVNSHRDYSIYQSIVPDIKCFQDDASGFFGPLMGMKSAWSHVRADYVLFIPCDVTYIPTQVVAKLHSALRKNKQAQAAYVSINGDALYPFCLLKRESLEVLEQQIDKQQLSLKNCFKLLHAQVAIFQKQNLFFHSINSLDELQQYKQIKAFKEIFSTN
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1362_STRPS
Sequence: MSNIYDSANELSRGLRGLPEYKAVKAAKDAIAADAEASKIFTEYLAFQEEIQKLAQTGQMPDASFQAKMEGFGKQIQGNSLLSEFFTKQQQLAIYLSDIEKIVFEPVSELLK
What are the official names of this protein?
UPF0342 protein SPCG_1362.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: F16PA_BURCH
Sequence: MSIARRTTLSKFLIEQQRETNNLPADLRLLIEVVARACKAISYNVSKGALGDALGTAGSENVQGEVQKKLDILSNEILLDANEWGGNLAAMASEEMETFFPIPANYPRGEYLLVFDPLDGSSNIDVNVSIGTIFSVLRCPDGKQATEESFLQPGTEQVAAGYAVYGPQTVFVLTTGNGVNCFTLDREVGSWVLTQSNMQIPADTREYAINASNARHWYDPVKRYVDELNAGKDGPRGDNFNMRWIASMVADVHRILNRGGIFMYPADKRTPDRPGKLRLMYEANPMSFIVEQAGGAATTGTQRIMEVQPTGLHQRVPVFLGSKNEVKRVTGYHDEAK
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_DEHMB
Sequence: MAKQIIFGEKVRVSLKKGVDTLANTVRVTLGPKGHPVALERKWGAPTVIDDGVTIARDIELPDAFENMGAQLVKEAATRTSDAAGDGTTTSIVLAQALINEAFKNIAAGAEPINLKRGIEKAVAALKAQLRKNSTPVKGKQQIVQVATITGKDPEIGNLIADVMDKVGKDGVITIEESRGLRYETSYVEGMQFDRGYISAYFVTDPGRMESVMEDATILMTDRKIETVAELLPALEKILQISKNLVIVAENVEAEALATLVVNKLRGNLNILAVKAPGYGDRQKAMLEDMAILTGGHVISKEAGRKLDSVTEADLGHARRIVSNKDKTTIIDGEGSAEAIKDRIKQIKAQIEETESAFDREKLQERQAALVGGVAVIAVGAATETEMKERKARVEDALAATRAAIEEGILPGGGTGLLNALPCLDALKLEGDEATGVNIVRKALIEPVRWIATNAGKDGNVIVDKVKNSPVGHGYNAENDVFGDMAEMGIIDPTMVVRSALENAASIANMVLITDSLVADIQEKAPAAPGPEAAGMY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WHIA_BACC2
Sequence: MSFASETKKELTNLEMKECCEKAELSALLRMNGSLSFSNRRLSIDIQTENAAIARRIYTLLKKGYDVTVELLVRKKMRLKKNNVYIVRLVEKSREILADLHIVRDDFSFIRNISQELIEKKCCKRSYLRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDAICELMNGFDLNSKTLERRKGYITYLKEAEKITEFLNIIGAHNALLRFEDIRIVRDMRNSVNRLVNCETANLNKTIGAALRQIENIRYIDETVGLDILPDKLREIAQLRRDYQDVTLKELGEMVSGGKISKSGINHRLRKIDEIAEKLRAGETVAKK
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: ERG3_LEPMC
Sequence: MDIVLEVCDTFLFDPLYATLLPAQASSFTANATANATLSSIRQEPTAYALPHASWQYEPATKYFSIEPSKYAYMSSWPRDDWRRQALTLYLITWLFGVCVYYLFAGLSYLLVFDKATFNHPRYLKHQIKLEMKQANIAFPIMAIFTVPWFLAEVRGYSKLYDTTEKGPGRWYDYLQIPFFIAFTDLCIYWIHRGLHHPMVYKHIHKPHHKWIMPTPFASHAFHPIDGYAQGLPYYIFPFLFPLSKIASVAFFVFVNIWTVLIHDGEYAHNSPIINGAACHTMHHLYFNYNYGQFTTLWDRLGGSYRKPNDELFKRELKMCQDEWNKQAKAVDMMVEQVEGENDRSYQGEPESKKVQ
What is the function of this protein?
Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol.  May contribute to the regulation of ergosterol biosynthesis.
What are the official names of this protein?
Delta(7)-sterol 5(6)-desaturase, C-5 sterol desaturase, Ergosterol Delta(5,6) desaturase, Sterol-C5-desaturase.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PDXB_SHEB9
Sequence: MKILVDENMPYVEPLFGDLGDIIPVNGRTLTAEQVREADVLLVRSVTKVNAELLSGNNKLKFVGSATIGTDHVDLAYLAERNIPFSNAPGCNATAVGEFAFIAMLELAQRFNSPLKGKVVGIVGAGNTGTATAKCLQAYGIKVLLNDPIKAAEGDPRSFVSLETIMAQADIISLHVPITRTGEHKTKYLFDEARLKALKPNTWFVNCCRGDVIDNQALIKVKQQRDDLKLVLDVWEGEPTPLPELVPLAEFATPHIAGYSLEGKARGTFMLYQKLCQLLNITADKSLLDLLPSFNIKAVELATAPNEKALLQLARFVYDLRDDDKMFRNTFLNENGFDTMRKNHQHRREFSALALAYDGQSEVDWLSNLGFSGVGQ
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_STRMU
Sequence: MKTLEKKLAEDFKIVFSDKELLETAFTHTSYANEHRLLNISHNERLEFLGDAVLQLTISHYLFDKYPQKAEGDLSKMRSMIVREESLAGFSRNCHFDRYIKLGKGEEKSGGRQRDTILGDLFEAFLGALLLDAGLKAVEAFLNQVVIPKVENNNYERVTDYKTALQELLQVDGDVLIDYEVLKESGPAHAKCFEVAVSMNHEKLSSGTGKSKKLAEQEAAKNALEKLQRGS
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  In this organism endogenous ribonuclease 3 and Cas9 are required for correct coprocessing of pre-crRNA and the trans-encoded small RNA (tracrRNA).  Cas9, crRNA and tracrRNA are required for cleavage of invading DNA (Probable).  Complements pre-crRNA and tracrRNA coprocessing defects in an rnc deletion in S. pyogenes strain 370 (PubMed:24270795).
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24E_ARCFU
Sequence: MEKRVCSFCGYDIEPGTGKMYVRRDGRVFYFCSGKCEKNMLKLKRKPRKLKWTKHYSR
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
Protein: GERPA_BACSU
Sequence: MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNTGDSLKVMNYQNATNVYDNDAVDQPIVANA
What is the function of this protein?
Required for the formation of functionally normal spores.  Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor.
What are the official names of this protein?
Probable spore germination protein GerPA.
What is the protein family that this protein belongs to?
Belongs to the GerPA/GerPF family.
Protein: RS4_STRA5
Sequence: MSRYTGPSWKQSRRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFSYGLGEKQFRNLFVQATKAKEGTLGFNFMVLLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSYRVTPGQVISVREKSMKVPAILEAVEATLGRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RL6_LISIN
Sequence: MSRIGKKTIVIPAGVTVTLNGSTATVKGPKGELVKEFNPEITINIEGNEINVSRPTDNKNHRALHGTTRAILNNMVVGVSEGYEKKLELIGVGYRAQKQGDKLVLNVGYSHPVEFVAPKGVEIEVPANTQVIVKGYNKEHVGELAANIRAVRPPEPYKGKGIRYEGEHVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: Y4545_BACC1
Sequence: MNGIRDVVKEEQPRERLLLEGAGSLSNRELLAVLLRTGSKEETVLKLSDKILHHFDGLRMLKDATLEELVSIHGVGVAKATQLIAAFELGRRMVRLEYQNRYSIRSPEDCATYMMEEMRFLQQEHFVCLYLNTKNQVIHRQTIFIGSLNSSIVHPREVFKEAFRRAAASIICLHNHPSGDPAPSREDIEVTKRLVECGRIIGIEVLDHIIIGDHKFVSLKEKGHI
What are the official names of this protein?
UPF0758 protein BCE_4545.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: SYC_RICPR
Sequence: MKLHLYNTLTRTKEVFNPQDPANIKMYVCGPTVYDNPHIGNSRSVVVYDLLYRIIIKIFGKKAVKYVRNITDVDDKIIDRAELLGITINDLTDKVTREFHINMEYLGCMLPTIEPKATEHIDVMIEIIERLIAKDHAYIADNHVYFDVLSAPNYTELSNRNLEAMFEGVRIENSKTKKNPQDFVLWKPAKKNEPENINFTSPWGLGRPGWHIECSAMSYKYLGQNFDIHGGGADLIFPHHTNEIAQSRCAFPSSTYAKYWIHNGFLTVNGSKMSKSLGNFITVRDLMDKQIQGEVVRLFLLSSHYRRPLDYNDKAIDDAKKTLDYWYRAIEHINVQKVDLPSNFMRSLFDDMNTPLAIKIINDYAKCVFISKTEAERKFNASAIITCANFIGLMRKTQYEWFNRDVDEFYINELINKRLKAKKQKNWLLADKIRNQLLEKKIILEDKSNYITIWRKE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMO_PSYCK
Sequence: MPNISTESVNTTIAPSQPASIPKDTATLFNPAKPTAMPAQSSTDSVQPYHHKANHNQNRSVEQSSEVVSAASAKTTTATTNAPVNAAPKIGFVSLGCPKALVDSERIITELSRDGYQVASDYEGADLVVVNTCGFIESAVQESLDAIGEAISKNGKVIVTGCLGKEADKIREMHPAVLAVTGAHAYDDVIRAVALHVPKPDCGLDASYDPKIDLINEAGIKLTPSHYAYLKISEGCNHRCTFCIIPSLRGDLVSRPIDSVMNEALALKKAGVKELLIISQDTSAYGLDLKYKTSFWNGMPLKSKFYDLCQALNDLGIWVRLHYVYPYPHVDKVVELMGEKKLLPYLDIPFQHASHRILKAMKRPAHSENTLARIHAWREICPDIVIRSTFVVGFPGETEEDFQCLLDWLVEARLDRVGAFTYSEVEGAVANDLPNHVPEDVKQERYERLMTLQQDISAQKLQEKIGKTLMVLVDEIDREEGVAICRSYADAPEIDGHVYVDDIDAHVKVGQFLTVTIDDASEYDLFASYKG
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_SALPA
Sequence: MKPDIHPVYRTVVFHDTSANEYVKVGSTIKTEREIELGGVTYPYVTIDVSSKSHPFYTGRQKTFDSESSAARFQKRFGHFIGAKRG
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: FXR1_DANRE
Sequence: MEELTVEVRGSNGAYYKGFVRDVHDDSLSISFENNWQPERQVPFSDVRLPPSADTKKEIGEGEEVEIFSRANEQEPCGWWLAKVRMMKGDFYVIEYAACDATYNEIVTFERLRPVNRNKAVTESTFFRCSVPVPEDLRAACESEQAHKEFKKAVGAIRIVYSPEKSELVVLSLSEATVKRVSLLSDIHLRSIRTKLMLMSRNQEATKHLESTKQLASAFQEEFTVREDLMGLAIGSHGSNIQQARKVPGVTAIELEEETGTFRIYGESTEAVQKARNYLEFLEDSVQIPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNDNKLPRQEGMVPFTFVGTKESISNVQVLLEYHIAYLNEVEQLRLERLQIDEQLRQIGMGFRSVPNRPADKEKGFGPDESSSGSIHTQRSYRGRGRRGPAHTSAYGTNSEHSYTSETDSERKAELSDWSLAADESERNPRPQRDSRRRDLRGRGRGSRGRGASNSISSVLKDPDGNPYSLLDNTETDQTADTDGSESQMNTSRRRRSRRRRTDEDTTVMDGMSESDNASLSENGLVTVADYISRAESQSRQTNPRDTRKSKKDMTRGDFISEHSAAESVSNGPNNADEPSESAKAVVNGVS
What is the function of this protein?
mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as heart and muscle development (PubMed:19648401, PubMed:20417602).  Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity).  Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity).
What are the official names of this protein?
RNA-binding protein FXR1, FMR1 autosomal homolog 1.
What is the protein family that this protein belongs to?
Belongs to the FMR1 family.
Protein: CI072_RAT
Sequence: MSTICPPPSPAVAKTEIALSGESPLLAATFAYWDNILGPRVRHIWAPKTDQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIVLEGTERMEDQGQSIIPMLTGEVIPVMELLASMRSHSVPEDLDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAERKCSRLCEAESSFKYESGLFVQGLLKDATGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEHIYNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFHLKPGLSLRSTFLAQFLLILHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEKIKPGLHSFIFGRPFYTSVQERDVLMTF
What is the function of this protein?
Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy.  In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation.  The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and modulating its protein kinase activity.  As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (By similarity).  Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ULK1/ATG1 kinase complex to the phagophore which leads to autophagosome formation.  Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates.  Plays a role in endosomal trafficking.  May be involved in regulating the maturation of phagosomes to lysosomes.  Promotes the lysosomal localization and lysosome-mediated degradation of CARM1 which leads to inhibition of starvation-induced lipid metabolism (By similarity).  Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation.  This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of CFL1/cofilin, leading to cofilin activation.  Positively regulates axon extension and axon growth cone size in spinal motor neurons.  Required for SMCR8 protein expression and localization at pre- and post-synaptic compartments in the forebrain, also regulates protein abundance of RAB3A and GRIA1/GLUR1 in post-synaptic compartments in the forebrain and hippocampus (By similarity).  Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity.
What are the official names of this protein?
Guanine nucleotide exchange factor C9orf72 homolog.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasm, Stress granule. Endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Secreted. Cell projection, axon. Cell projection, growth cone. Perikaryon. Note=Detected in the cytoplasm of neurons from brain tissue. Detected in the nucleus in fibroblasts. Associates with cytoplasmic stress granules following cellular stress. During corticogenesis, transitions from being predominantly cytoplasmic to a more even nucleocytoplasmic distribution.