PharMolix/UniProtQA huggingface dataset:
Protein: MNME_BRUC2
Sequence: MSEIGSYHDTIFALSSGRLPSGVAVIRISGPKTRFVYETICQAIPEPRHAALLTFRSRNGDAIDRGLILFFPAPHSFTGEDCAEFHLHGGKAVVEKMLAVLGELPGCRIAEAGEFTRRAFANGKMDLTIAEGLADLIAAETEGQRRLAMQVASGNQRKLYSEWRQRLINARAFIEAELDFADESDVPGSVSMQVWQQLSALKHEIEHHIASGKRAAMLRDGLHVVIVGAPNAGKSSLLNFLAGRDVAIISKEAGTTRDLLEVKLDLGGIPVYVTDTAGLRETDSVVEKIGIERARARMAEADLVLSLEDMSGPVSVTVEKIEAETWLIGTKADLGGSASGLWKYHISTMTGSGLEQLLDALQAFAEAKIGQIEDAVPTRQRHINLLRATIEEIEKAIEGDDLPLELRAENMRLASQFLGRITGDVDVEEILDVIFSQFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2AD_NAJSP
Sequence: MNPAHLLILAAVCVSPLGASSNRPMPLNLYQFKNMIQCTVPNRSWWDFADYGCYCGRGGSGTPVDDLDRCCQVHDNCYGEAEKISRCWPYFKTYSYECSQGTLTCKGGNDACAAAVCDCDRLAAICFAGAPYNDNNYNIDLKARCQ
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 D, svPLA2, APLA, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NTP1_VARV
Sequence: MSKSHAAYIDYALRRTTNMPVEMMGTDVVRLKDYQHFVARVFLGLDSMHSLLLFHETGVGKTMTTVYILKHLKDIYTNWAIILLVKKALIEDPWMNTILRYAPEITKDCIFINYDDQNFRNKFFTNIKTINSKSRICVIIDECHNFISKSLIKEDGKIRPTRSVYNFLSKTIALKNHKMICLSATPIVNSVQEFTMLVNLLRPGSLQHQSLFENKRLVNEKELVSKLGGLCSYIVNNEFSIFDDVEGSASFAKKTVLMRYVNMSKKQEEIYQKAKLTEIKTGISSFRILRRMATTFTFDSFPERQNRDPGEYAQEIATLYNDFKRSLRDREFSKSALDTFKKGELLGGDASAADISLFTELKEKSAKFIDVCLGILASHGKCLVFEPFVNQSGIEILLLYFKVFGISNIEFSSRTKDTRIKAVAEFNQESNTNGECIKTCVFSSSGGEGISFFSINDIFILDMTWNEASLRQIVGRAIRLNSHVLTPPERRYVNVHFIMARLSNGMPTVDEDLFEIIQSKSKEFVQLFRVFKHTSLEWIHANEKDFSPIDNESGWKTLVSRAIDLSSKKNITNKLIEGTNIWYSNSNRLMSINRGFKGVDGRVYDVDGNYLHDMPDNPVIKIHDGKLIYIF
What is the function of this protein?
DNA-dependent ATPase that acts as a 5' to 3' translocase on single-stranded DNA and thereby plays a role in transcription termination of viral early genes.  Uses forward translocation in concert with the viral RNA polymerase RAP94/OPG109 subunit and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex.  In addition, acts as a positive elongation factor to assist transcription through problematic sequences.
What are the official names of this protein?
Nucleoside triphosphatase I, NPH-I, Nucleoside triphosphate phosphohydrolase I, NPH I.
What is the protein family that this protein belongs to?
Belongs to the helicase family. NPH I subfamily.
What are the subcellular locations of this protein?
Virion. Note=Virion core enzyme.
Protein: RIMM_ALISL
Sequence: MSKQDEVIVVGKFGASYGIRGWLKVVSFTDQPESIFDYKPLLIKVKDEWVEFSVESWKRHKGLVCKLEGLEVREEAQAYTNLEIAVKADALPELSEDEFYWRELFGMEVVTSQGYGLGIVDDIFETGSNDVLVVKANLKDAFGKKERLIPFIDEQVIKVIDREAQRIEVDWDPGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR6N2_HUMAN
Sequence: MDQYNHSSLAEFVFLGFASVGYVRGWLFVLLLLAYLFTICGNMLIFSVIRLDAALHTPMYHFVSVLSFLELWYTATTIPKMLSNILSEKKTISFAGCLLQTYFFHSLGASECYLLTAMAYDRYLAICRPLHYPIIMTTTLCAKMAAACWTCGFLCPISEVILASQLPFCAYNEIQHIFCDFPPLLSLACKDTSANILVDFAINAFIILITFFFIMISYARIIGAVLKIKTASGRKKAFSTCASHLAVVLIFFGSIIFMYVRLKKSYSLTLDRTLAIVYSVLTPMVNPIIYSLRNKEIIKAIKRTIFQKGDKASLAHL
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 6N2, Olfactory receptor OR1-23.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NELFA_HUMAN
Sequence: MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVDEMKGALMEIIQLASLDSDPWVLMVADILKSFPDTGSLNLELEEQNPNVQDILGELREKVGECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKPKSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMDTTTPLKGIPKQAPFRSPTAPSVFSPTGNRTPIPPSRTLLRKERGVKLLDISELDMVGAGREAKRRRKTLDAEVVEKPAKEETVVENATPDYAAGLVSTQKLGSLNNEPALPSTSYLPSTPSVVPASSYIPSSETPPAPSSREASRPPEEPSAPSPTLPAQFKQRAPMYNSGLSPATPTPAAPTSPLTPTTPPAVAPTTQTPPVAMVAPQTQAPAQQQPKKNLSLTREQMFAAQEMFKTANKVTRPEKALILGFMAGSRENPCQEQGDVIQIKLSEHTEDLPKADGQGSTTMLVDTVFEMNYATGQWTRFKKYKPMTNVS
What is the function of this protein?
(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
What are the official names of this protein?
Negative elongation factor A, NELF-A, Wolf-Hirschhorn syndrome candidate 2 protein.
What is the protein family that this protein belongs to?
Belongs to the NELF-A family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLC7D_CAEEL
Sequence: MTATIDVDNLMSRLLNVGMSGGRLTTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKSLRKG
What is the function of this protein?
Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis (PubMed:16943775, PubMed:22042574).  In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium (PubMed:22042574).
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1-delta, CeGLC-7-delta, Glc seven-like phosphatase 4.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family.
What are the subcellular locations of this protein?
Chromosome. Cell projection, pseudopodium. Cytoplasm. Note=Co-localizes with MSP in oblong stripes in the cytoplasm of inactive sperm and in the pseudopodium in activated sperm.
Protein: VF282_IIV6
Sequence: MINEDIDILSLDNKIKLHFESEIQKYKRYNERLLCIENLLKIENLRPKIFLDLLMDKKYLEKKLVNLSNLDLYSIETSDIIHRYLTIINTPLNIEVALTSQKPTEINNLVLKRRETVQEFIKVAKSYLTEPLLKSLQLMGNFGKEDLLNSIPVVCTCGNDKDFYKDDDIYICQLCNAETVKLLNSSSVNDGGRINVCNKYTYDRKVHFKDCINQYQGKQNTNINPRIYDELEEQLVNHQIIEPANKKDKFGNPISQSKRFKIVTRAHILFFLKELGYTKHYEDTILIHYTLTGKRPDNIEHLEEKLMADFDKLTEQYDLLFKDIERKNFINTQYVLFQLLRKHGYNCNKDDFAVLKTTERKACHDDICKTLFDALGWKYMFVM
What is the function of this protein?
Transcription activation.
What are the official names of this protein?
Putative transcription factor 282R.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 282R family.
Protein: NUOK_BRUA1
Sequence: MEIGIAHYLTVSAILFTLGVFGIFLNRKNVIVILMSIELILLSVNLNFVAFSSQLGDLVGQVFALFVLTVAAAEAAIGLAILVVFFRNRGSIAVEDVNVMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARNB_PECCP
Sequence: MTDFLPFSRPSMGEEEIAAVAEVLRSGWITTGPKCQQLEQAFCQQVGCRQAIAVSSATGGMHVTLMALGIGPGDEVITPSQTWVSTVNMITLLGAEPVMVDVDRHTLMVRPQDIEAAITPKTKAIIPVHYAGAPADLTALRTLSERYGIPLIEDAAHAVGTQYRDEWIGARGTAIFSFHAIKNITCAEGGMVVTDDEALAERIRSLKFHGLGVDAFDRQRQGRKPQAEVVTPGFKYNLADINAAIALVQLDKLPAINARRQQLAARYLTQLRSLPLQPLAVPDYPHLHAWHLFMVRVDETRCGISRDGLMAALQTHGIGTGLHFRAVHTQKYYRERYPHLHLPETEWNSASLMTLPLFPDMQDSDVDRVVVALTSILESVRD
What is the function of this protein?
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase, UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase, UDP-Ara4O aminotransferase, UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
Protein: GBRA1_MOUSE
Sequence: MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:27129275).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275).  The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275).  The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:27129275).  GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (PubMed:25348603).  Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
Protein: COBQ_JANMA
Sequence: MVQGTTSDAGKTTLVAALCRLLAQEGVRVVPFKPQNMALNSAVTADGGEIGRAQALQAVAAGLQPHTDMNPILLKPSSDTGAQVIIHGKARSDMNARDYHAYKPIAMQAVLESYQRLQTQYESVLVEGAGSPAEVNLRERDIANMGFAEAVDCPVILVADIDRGGVFAHIIGTLACLSESERRRTVGFVINRFRGDISLLEPGLKWLEEQTGKPVLAVLPYLHGLFLDAEDAVEHTQAVRGAFRVVVPVPPRISNHTDFDALRAHPEIDLQLVGPGQPIPAADLIILPGSKNTRGDLEWLIANGWREALLRHLRYGGKIIGICGGYQMLGMTVADPHGVEGTPGESAGLGLLDVATELTRDKRLEQVSGVCAFADVGVSGYEIHMGTSDGAARAQPAFLIDGRPEGARSADDQVLGTYLHGLFDTPDACAALLHWAGLNSDVRVDTAQLREASLQRLAAAARPLLAALRALPDYSR
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: SYT_PHOV8
Sequence: MIKITFPDGSVREYNEGVTGLQIAESISSRLAQDVLACGVNGETIDLSRPINEDANFVLYKWEDEQGKHAFWHTSAHLLAEALQELYPGIQFGIGPAIENGFYYDVDPGEAIIKEADLPAIEAKMAELAAKKEILVRQSIAKEDALKKFGERGETYKCELISELEDGHITTYTQGAFTDLCRGPHLTSTAPIKAIKLLTVAGAYWRGQEDRKQMTRIYGITFPKKKMLDEYLVMLEEAKKRDHRKIGKEMDLFMFTDMVGKGLPMWLPKGTALRIRLQDFLRRIQARYDYQEVMCPPIGNKNLYITSGHYAKYGKDSFQPIHTPEEGEEYFLKPMNCPHHCMIYKNSPRSYKDLPLRIAEFGTVCRYEQSGELHGLTRVRSFTQDDAHLFCRPDQVKEEFLRVMDIINIVFKSMNFENVEAQISLRDKVNREKYIGSDENWEKAEQAIIEACEEKGLTAKVEYGEAAFYGPKLDFMVKDAIGRRWQLGTIQVDYNLPERFQLEYMGSDNQKHRPVMIHRAPFGSMERFVAVLIEHTAGKFPLWLTPDQVAILPISEKFNEYAEQVKAELRKFDVRAIVDDRNEKIGRKIRDNEMKRIPYMLIVGEKEAENGEVAVRKQGEGDKGTMKIEEFGKNLAEEVSNMINKW
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APH1B_PONAB
Sequence: MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGTFVSVYIQEMFRFAYYRLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKDFLLYNQRSR
What is the function of this protein?
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein).  It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.  Probably present in a minority of gamma-secretase complexes compared to APH1A (By similarity).
What are the official names of this protein?
Gamma-secretase subunit APH-1B, APH-1b, Aph-1beta.
What is the protein family that this protein belongs to?
Belongs to the APH-1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MLTF_ECOK1
Sequence: MKKLKINYLFIGILALLLAVALWPSIPWFGKADNRIAAIQARGELRVSTIHTPLTYNEINGKPFGLDYELAKQFADYLGVKLKVTVRQNISQLFDDLDNGNADLLAAGLVYNSERVKNYQPGPTYYSVSQQLVYKVGQYRPRTLGNLTAEQLTVAPGHVVVNDLQTLKDTKFPELSWKVDDKKGSAELMEDVIEGKLDYTIADSVAISLFQRVHPELAVALDITDEQPVTWFSPLDGDNTLSAALLDFFNEMNEDGTLARIEEKYLGHGDDFDYVDTRTFLRAVDAVLPQLKPLFEKYAEEIDWRLLAAIAYQESHWDAQATSPTGVRGMMMLTKNTAQSLGITDRTDAEQSISGGVRYLQDMMSKVPESVPENERIWFALAAYNMGYAHMLDARALTAKTKGNPDSWADVKQRLPLLSQKPYYSKLTYGYARGHEAYAYVENIRKYQISLVGYLQEKEKQATEAAMQLAQDYPAVSPTELGKEKFPFLSFLSQSSSNYLTHSPSLLFSRKGSEEKQN
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: SLD2_KLULA
Sequence: MNGIKETDTVNAPLLLVISSASMDALKIEIKLWERAFEKEHGRLPEKDDIKKDKEVKRKYKQYAQLKKDATVKPSVEVNVEQTPVKSHVNNTKAEFGPTPQMNGKLVSIFEMQVSAMKTHQSDQEDIVGSPVRSNDLVRRQLNFSITPNSSPMKQVPNLSANIVVSRPKYGPNSPMRIGDIGLQLSETPKTLGRTLDLKSSPFSPSPLIKRPVKTLSQLAKEHAIIKDEFESNPEDFSEFTAIRTLMEKLMQEEHMDIIEEGDEGTVGNETESNYVRKVKTIKKRTKAKMRPAALNEKSTNIPDKNVHEQLAKLKEREYNKMLGKEVEESESDSEQQSNPPVKKKQRKSKYNLVSNNFKRLNLPTKAGRNRASKWRGRR
What is the function of this protein?
Has a role in the initiation of DNA replication.  Required at S-phase checkpoint (By similarity).
What are the official names of this protein?
DNA replication regulator SLD2.
What is the protein family that this protein belongs to?
Belongs to the SLD2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ASTD_VIBPA
Sequence: MTHWIAGEWVQGQGEEFVSLSPYNQEVIWRGNGATAEQVDQAVAAARAAFVEWKKRPFAEREAIVLAFAEKVKENSEKIAEVIAKETGKPIWETRTEAAAMAGKIAISIRAYHDRTGEATREAAGNQIVLRHRPLGVMAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSEQTPWTGELAMKLWEEAGLPKGVINLVQGAKETGIALADAKGIDGILFTGSANTGHILHRQFAGQPGKMLALEMGGNNPMVISDNYGDLDATVYTIIQSAFISAGQRCTCARRLYVPFGEKGDALITKLVEATKNIRMDQPFAEPAPFMGPQISVAAAKFILDAQANLQSLGGESLIEAKAGEAAFVSPGIIDVTNIAELPDEEYFGPLLQVVRYEGLDKAVELANDTRFGLSAGLVSTDDQEWEYFVDHIRAGIVNRNRQLTGASGDAPFGGPGASGNLRPSAYYAADYCAYPMASMEGQETELPATLSPGVTL
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: TRUD_ECO7I
Sequence: MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEIPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAAETELQALLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: TRPB_METPP
Sequence: MLNYQQPDASGHFGRYGGSFVAETLIHALDELKAAYARYRDDPEFVAEFKSELAHFVGRPSPIYHAARMSRELGGAQIYLKREDLNHTGAHKINNTIGQALLARRMGKPRVIAETGAGQHGVATATICARYGMECVVYMGSEDVKRQSPNVYRMHLLGARVVPVDSGSKTLKDALNEALRDWVTNVENTFYIIGTVAGPAPYPEMVRDFQSVIGEECLRQMPEMAGRQPDAVIACVGGGSNAMGIFYPYIRHEGVRLIGVEAAGHGLDSGKHAASLSAGSPGVLHGNRTYLLQDANGQIIETHSISAGLDYPGVGPEHAYLKDIGRAEYVGITDDEALQAFHRLCRTEGIIPALESSHAVAYAMKLAPTMRSDQSLLVNLSGRGDKDIGTVADLSGAEFYDRPSSRGEKVKQ
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: Y885_XYLFT
Sequence: MGRGPSIEARKNASDSKRGKIFTKIIRQIGVAARAGGGDPSNNPSLRVVIDKALASNMSKDVIERAIKKAIGEMEGVQYEEVRYEGYAPGGVAVIVDCLTDNRLRTVSDVRHAFSKCGGNMGTEGSVAFMFKRLGVLSYAHAIADEERITEAAIDAGAEDVMVYIEDDEIEVITTPEAFSRVKEEMAALGLMPYHAEITFRADSDIVVDGDTAIQVRKLLDILEDLDDVQDVYSNVDQVTLGKR
What are the official names of this protein?
Probable transcriptional regulatory protein PD_0885.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTMR4_XENLA
Sequence: MGDEPPSLEYIQAKDLFPPRELVKEEEKLQVPFPVLPGEGVEYLGSANDAVIAISNYRLHIKFKDSVVNVPLRMIEAVESRDMFQLQIICKDSKVVRCHFSTFKQCQEWLKRLSRATLRPAKQEDLFAFAYHAWCQGVCTDEEEPLIHLCRPGDHVKSRFQIELKRMGFDLQNAWRVSEINNNYKLCQSYPQKLLVPVWITDKELENVATFRSWKRIPVVVYRHTRTGAVIARCSQPEISWWGWRNADDEYLVTSIAKACALNPAVRMPNGNPSNKGNNDGSDNSDTDFDSSLTACPVEGGGVPQKLLIVDARSYTAAVANRAKGGGCECEEYYPNCEVAFMGMANIHSIRNSFQYLRAVCNQVPDPGNWLSALESTKWLQHLSAMLKAATVVASAVDREERPVLVHCSDGWDRTPQIVSLAKILLDPYYRTLEGFQVLVETDWLDYGHKFADRCGHQENREDQNEQCPVFLQWLDCIHQLLFQFPCHFEFNHAFLVKLVQHTYSCLYGTFLANNLCEREMRNIYKRTCSVWSLLRTGNKIFHNLLYMPGSDLVLHPVCHVRALQLWTAVYLPATSPCTPMDDRMEMYLTPASQGPQFHARSLVRLPKTRSMDNLLTACDSGGLLTRTSSDPNLNNHQGNLESCSSSKEGNETEICDIQQQALSIEPKEEDGNDSKSTDHENEDSGSATNQNNNEQNALNNILSIAKPDSIQCKRDRFKSVLEKSSVIPVPSNEGTITDDNSHSNGTSEHLPVPALVTNGSVQNKSCVDVSKAMKLSTELSRTDKKPVFQTQRDEFSFCTSNWDSLPGMMRSVPICEVGLRRPLSYDCSTRSQHSRNGRHTMKLTGNLPASFHCSGPFTKRCRCVMACHTKQVQGSRFLPLACPSPAPLIYQDDDGLPIPSDVVQQRLRQMEASYKQEVDLLRRQVWELQLQLEIRQYCAPPSEPEADYEDDFTCVKESDGSDMDDLYSDKSEDRLSEASWEPVDKKETEVTRWVPDHMASHCFNCDCEFWLAKRRHHCRNCGNVFCAACCHLKLPIPDQQLYDPVLVCNTCYDHIQVSRARELMSQQLKKPLTAASS
What is the function of this protein?
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate.  Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).
What are the official names of this protein?
Myotubularin-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region.
Protein: FEN_METKA
Sequence: MGLAELRELIEPEETDLRALAGREIAIDAFNALYQFLTTIMKDGRPLMDSRGRITSHLNGLLYRTVNLVEEGIKPVYVFDGEPPDLKRETLERRRERKEEAMEKLRRAKTKEEREKYARQVARLDESLVEDAKRLLDLMGIPWVQAPSEGEAQCAYMARCGDVWATGSQDYDSLLFGSPRLVRNITIVGKRKHPHTGEIIEVKPEIMRLEDVLDQLGLESREQLVDLAILLGTDYNPDGVPGIGPKRALQLIRKYGSLDELKDTDIWPKIERHLPVEPEKLRRLFLEPEVTDDYELDWDEPDEEGLVEFLVEERDFSEDRVRRAVERLKEALQELRKGGRQETLDAFF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: SSRP_CLONN
Sequence: MGKKDKKNNTLAQNRKAYHDYFIEETFEAGIALVGTEVKSIRGGKANLKDSYASIRNGEVFVCNMHVSPYEQGNIFNRDPLRERKLLLHKSQINTLLGYTAQQGYTLIPLSLYLKNGRVKVALGVAKGKKNYDKRDAIAAKAAKRDIDRQMKERMRY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.