PharMolix/UniProtQA huggingface dataset:
Protein: LEPG_ASPFN
Sequence: MKHRRYKLDDSNLLLSSPCAVASCWYSENPATLSPPRPRHTMPASVHFEISATQRAIKIKGPGQASVEKGCPVPACQPEDILVRVVCVALNPVDWKSADLSPSLDATWGTDFSGEVVVVGEACQSRFALGDSVCGAAFGNNPEDATQGAFAEYVAIPGELVYKIPPDISFEQAATVGTGLATAGLTLYQTLGLSWPDQPVQDAQYVLVYGGGTASGCFMIQLLRLSGYIPVTTCSAKSFDRVKQLGAAEAFDYHSPGCGSEIREYTENSIKYAVDCITNIDSMKCCYTAIGSSGGQYVALDPFPIRGHTRRNVKARWIIGYTIYGRPINWKHPFKRDAQPQDREFAKRWYPVAQRLLDEGKLQLHPLQVETGGLPGVIEGANRSRKHQVTGVKLVYCV
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster 23 that mediates the biosynthesis of a family of 2-pyridones known as leporins (PubMed:20447271, PubMed:26051490).  The hybrid PKS-NRPS synthetase lepA and the enoyl reductase lepG are responsible for fusion of phenylalanine with a hexaketide and subsequent release of the stable tetramic acid precursor, pre-leporin C (PubMed:26051490).  Because lepA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase lepG (PubMed:26051490).  It is possible that the dehydrogenase lepF also participates in production of pre-leporin C (PubMed:26051490).  Cytochrome P450 monooxygenase lepH is then required for the ring expansion step to yield leporin C (PubMed:26051490).  Leporin C is then presumably further oxidized by the N-hydroxylase lepD to form leporin B (PubMed:26051490).  LepI may possess a function in biosynthesis upstream of lepA (PubMed:26051490).  Leporin B is further oxidized in the presence of ferric ion to give the leporin B trimer-iron chelate, but whether or not this reaction is catalyzed by an enzyme in the pathway or by ferric ion is not determined yet (PubMed:26051490).
What are the official names of this protein?
Trans-enoyl reductase lepG, Leporins biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: DYL1_BOVIN
Sequence: MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
What is the function of this protein?
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules.  Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity).
What are the official names of this protein?
Dynein light chain 1, cytoplasmic, Dynein light chain LC8-type 1.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
Protein: Y1760_DROME
Sequence: MKCWHNVVRRRRKKPTAAAAAKGSKGSHGGVASPRDEDAICQRQQQVDTYTWLTTQAVPLLWLHLLLLVAFAKHAAAATTIATNPEATTTTVSNYTVTTTALSSSTTTTSSGSAPALSSAADKFAGNWANLEDSFRNIVRIGDGNTVTRTSIEQSLVTIHDIATENLGTLCISTLYRPLQVPINSERYESSRQKTDLAASILQEVGIIRHGGLSDALAKGLLTDDFITGARILALNLTNGAVQSYVWWVKGTAAEIQRYDEDGLQIGKKPAGSYPWFDDETSSPTLRSPKFAPSPPNNYYKGWWTYPYFSCSQSRWLVSYSIAIPPIGRHGLRGFISIDIDVSTLRVNQCEAEPYPFGSRRQKMQQLQTHNRLGARRSLFLGSRMGAIDESTINDLQAFHSSHKCHRTSMVCDYRQPSAETPTVTGGKLLTTLTGSSSWTRGSYQCLCRGGFYSLRHPDGFNGTIMEIAWQEQQDNISNYYSEVFKCLPCAPGCDTCTGPEPCLANYHWPFRISLLTISIGCACGTFVLAGYLFRHRRVKVFKVASPIFLMITLIGCAIMYLEMVAIFPYLDTTWCIATKWTRHMGFCITYTSLLMKTWRVSLTYRVKSAHKIKLNDQQLLQWMVPILLVMLIYLGTWTISATPTAEVILDQSQLKFKQCSYNWWDHSLAIGEVFFLAWGIRVCYNVRNAESLYNEARLISYAIYNIALVNIAMVVFHVMLFPNAGPDYKYMLGFVRTQLSTTTTIALVFGPKILRVFKGQGDKWDQKAKVRSITASFSLNGVGLVPEESPDLYQENEELKEQVQKLAHQIEFMKTVHMQMNNRHLKPKPGGYFTITSTSFQAPYSKNTVSTAQTQTGKDENSTPTKLKSPKGKVXRGQRSVKDCSIEIDGGQGRTTLVEDAIEFNFHLADTEKGLIVQEDERPGSDEEEAALIAQFRRLFAPILDDSLNLYYQLNDLDDTEHVRIHQTVAQMNDLTSSEEETMVTQVNSPSPPPVGVELLLPISSDSSTASSSLYAIHTPSPAHPSGVLLMPQNLESPLLSGSDAITITEQVELHNPPHHLQLLEDENNTSCSLSSNLTDSKTLDGRTPIVV
What are the official names of this protein?
Probable G-protein coupled receptor CG31760.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KUP_ECOSM
Sequence: MSTDNKQSLPAITLAAIGVVYGDIGTSPLYTLRECLSGQFGFGVERDAVFGFLSLIFWLLIFVVSIKYLTFVMRADNAGEGGILTLMSLAGRNTSARTTSMLVIMGLIGGSFFYGEVVITPAISVMSAIEGLEIVAPQLDTWIVPLSIIVLTLLFMIQKHGTAMVGKLFAPIMLTWFLILAGLGLRSIIANPEVLHALNPMWAVHFFLEYKTVSFIALGAVVLSITGVEALYADMGHFGKFPIRLAWFTVVLPSLTLNYFGQGALLLKNPEAIKNPFFLLAPDWALIPLLIIAALATVIASQAVISGVFSLTRQAVRLGYLSPMRIIHTSEMESGQIYIPFVNWMLYVAVVIVIVSFEHSSNLAAAYGIAVTGTMVLTSILSTTVARQNWHWNKYFVALILIAFLCVDIPLFTANLDKLLSGGWLPLSLGTVMFIVMTTWKSERFRLLRRMHEHGNSLEAMIASLEKSPPVRVPGTAVYMSRAINVIPFALMHNLKHNKVLHERVILLTLRTEDAPYVHNVRRVQIEQLSPTFWRVVASYGWRETPNVEEVFHRCGLEGLSCRMMETSFFMSHESLILGKRPWYLRLRGKLYLLLQRNALRAPDQFEIPPNRVIELGTQVEI
What is the function of this protein?
Responsible for the low-affinity transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Low affinity potassium transport system protein Kup, Kup system potassium uptake protein.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL23_ACET2
Sequence: MRPAEDIIKRPYITEKSNAEIANGKYTFIVDAKATKTEIRQAVEKLFQVKVLKVNTVNYKGKRKRLGVHEGFRPDWKKAIVKIDTEPKPVTYLTEGGKTATTTKKYKTSIEEFGAAQ
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: MUTL_XANOM
Sequence: MAIRQLPEMLINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNGGGIAPDELPLAVSRHATSKIASLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHGSALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFLRAERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGEDFARQALRVDHSGAGLRLHGWVAQPHYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYRTLQDALAHTRAGATPNSIGSDGAGYTGATAGEMGNIASGGPANHGNAPGRSGSAYSYANWTPSQTPLGLRVDEARAAYSALYAPPPRNAPQSTGMPSMAGTGLPATSEDSGVPPLGYAIAQLHGIYILAENAEGLIVVDMHAAHERIVYERLKNAHDSIGLHAQPLLVPMTLAVGEREADTAEREADTLATLGFEITRAGPQSLHVRSIPALLANAEPEALLRDVLGDLREHGQSCRIASARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLSDIDRWFLRGR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: CYSC_MICAN
Sequence: MKQRGVTVWLTGLSGAGKSTITEALQAKLIAEGYSIEVLDGDIVRTNLTKGLGFSKEDRDENIRRIGFVSNLLTRHGVIVLVSAISPYREIREEVRGKIGNFVEVFVNAPLSVCEDRDVKGLYKRARAGEIKSFTGIDDPYEPPFNPEVECRTDLETLEESVAKVWNKLTELGYIHQAVAV
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: RL14_HAMD5
Sequence: MIQQESMLNVADNSGARSVKCIKVLGGSRRRYACVGDIIVISIKEAIPRGKVKKGEVLKAVVVRTSKGVRRPDGSIIRFDTNACVILNKNTEQPIGTRIFGPVTRELRNEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ISPD_BUCAI
Sequence: MILVNLFEPKIIAIVPAAGIGSRMKIDVPKQYIKIQNRTILEHTLTTLLLHPNIVQIIVSLNKKDNYFHKLSISSNFRIISVVGGEKRINSVLSGLIVVKNVDWVIVHDAVRPCLSYKDLEKLISIIKKNPVGAILARPVSDTIKYSNLKQKKAVYTVYRKNLWHALTPQLFQVELLKNCLKKIIKDQISVTDEASALEYCGYNPLLVLGSCRNIKITWPEDLVLANFYLKNHIIDK
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: Y0617_DICDI
Sequence: MIENKIELNCALHTNKNLEFLCLDCKLIPCCTLCISRGGEHHRHGIDSLESIQTSSILSMMNNFKDVYPKVIERIENDQQILKDSDEIFNEIQSQYNKNKITINEEFKKIHNILSIIQLDIERQLTTDFQENTLINTTITSSINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSITDILNISIKYIQQQYNNDDHFKIDSNSIELIKQYQQSLLLLNNNNNDNLNKLKEYNNQTIKFDNQLINDIKNNLKTIYSFENNNNNNNNNNNNNNNNNNYNDNDNNNNYNDNNNNYNSNKAEKLNIEIDENNYKFIKKRNKNYYIYSENNEFPKNKEGIAFGEDCGSLLEFNWNKNLKNVMLLDGFKESLEPGVLPNGIVHLEIGDIKTPLVVGSIPSTVISLTFNDGFNQSLEPGVLLNSILNLRIGDIKTPLVVGSIPSSVFSLALHDGFNQSLEPGIIPQNNKYKDFSSMQGVKYLTLHNIKSELNIGSIPKSVYQLTLRDGFSKTLKPGVIPRSVEIVTLQEITKPLIIGSIPYTVLTVQFLTGFNQLLTPGIIPEGVKVLEFYQVKDLLTPGSIPKSIYSLSFKDGFDQILSPGIITDGVCELYLRGIKQPLVLNSIPNSVTKLDIYNEFNQELTPGIIPNSIKELTLGSLNTQLVEGSIPKTIQKIILYGNIEPSSLDVCKLDKSVLIYKK
What are the official names of this protein?
FNIP repeat-containing protein DDB_G0290617.
Protein: NFI_NANEQ
Sequence: MLSSKLLDINYWNKFGKRLINELINLIEQIPKGYVTTFKELAKALGDPIATKFVAMYYKKAPHWYRVVSSNLIVSPMQKALLEKEVKIIGNKVYAPIFKDFKSSKPLLELQKIQEYLVNKIKFDYPEYDYVIGIDIGYKNNIIALAIFDKNKKLIETKTCKHNIEFPYIPTYLSFREGIPIVNILKDLDYTALYIINGHGLSHPRKMGLATFVGTVLDLPTIGDAKKLLYGKIKNNIIYAHNMPVGYFVGHYVTIGNRTNLEFLKEFIKEWNSKKYLLPIEVADKITKCGRGDSNPGRD
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity).
What are the official names of this protein?
Bifunctional methyltransferase-like/endonuclease.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPE_BACSU
Sequence: MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNITIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQLIKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKRMADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK
What is the function of this protein?
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
What are the official names of this protein?
Ribulose-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the ribulose-phosphate 3-epimerase family.
Protein: TATA_MYCLE
Sequence: MGSLSPWHWVVLVVVVVLLFGAKKLPDAARSLGKSMRIFKSELREMQTENQAQASALETPMQNPTVVQSQRVVPPWSTEQDHTEARPA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: V224_FOWPN
Sequence: MNINATDNSLSTPLHHAINLLKTDIVSLLMQYKADASIRDSKGITPFCYAMYLGYYGVNKDILNIITRYNSINGTTRDINDVYTILLNNKKKNYVFVNLHDAARLGYVYILKKIIYNGKNINRIDEYYYSALHYAVKSSNLKAVNF
What are the official names of this protein?
Putative ankyrin repeat protein FPV224.
Protein: TDIR_THAAR
Sequence: MQATKTGNASTVFVVDDEASVRDSLTWLLNSISLDVRTFESAKDFLDADISCTHGCVVLDVRMQNVSGLQLQQALSERGFKLPIIFLSAYGDAQMGAQAVKKGAFDFLQKPYRNQDLLDAVNAALALNREMADKQNEKQKHLDLLATLSQREMEILDKVVAGSSSKEIAKLLGISYKTVEAHRGRIISKLGLKSTGDLMHFVMRGSSHCSDCGRQPLPGSSPCRPAA
What is the function of this protein?
Member of the two-component regulatory system TdiR/TdiS, which probably regulates transcription of toluene catabolic genes (bss operon).  Binds to DNA.
What are the official names of this protein?
Transcriptional regulatory protein TdiR.
Protein: FREE1_ARATH
Sequence: MQQGDYNSYYHHQYSQFQNPTPNPNPNPNPSPPAPATVAGPTDLTRNTYASAPPFTGGYGSADYSNYSQNYTPYGQNSEHVPPSAPSFTSPSQPPPSPPATSLNPNSYSTFNQPPPPPTIHPQPLSSYGSFDSTAPYQQPTSQHMYYSPYDQHQTSGYSSAPPPSSAPAPNPNPAPYSSSLYSAPPYSSGGSSIPPSYEKPSVKFDQSGYDGYNRSRSDLGSDLYGKRSDSGEYPAFEDSYGDGVYAYQGGKVEPYGSRGTAPKSSNSTLFDDYGRSISFSSSGRDSSVSSNSAKIVRAVPKADVQEDSTGGVQKFRVKLLAETYGQTTTDVLCQIGLDGLRMLDPSTSRTLRIYPLENITRCEKLDSSILAFWSKTPVDIEAKRIRLQSNSYTTNTLLDTVTAAMFQAKEIGGSSRPPTSGKLIEQTAEKKKGLGDWMNIIKPVNEEKDHWVPDEAVSKCTSCGSDFGAFIRRHHCRNCGDVFCDKCTQGRIALTAEDNAPQVRVCDRCMAEVSQRLSNAKETTGRNVSLQSHEDLARKLQEEMERNRKSSSGLREGSGRRMKEVACPTCTVHLQVQVPVSGSETIECGVCQNPFLVSAH
What is the function of this protein?
Endosomal sorting complex required for transport (ESCRT) component regulating multivesicular body (MVB) protein sorting and plant growth (PubMed:25438943).  Required for the formation of intra-luminal vesicles (ILVs)in MVBs (PubMed:25438943).  Binds to phosphatidylinositol-3-phosphate (PI3P) and ubiquitin (PubMed:24843126, PubMed:25438943).  Controls IRT1 recycling to the plasma membrane and impacts the polar delivery of this transporter to the outer plasma membrane domain (PubMed:24843126).  Regulates ubiquitin-dependent membrane protein degradation, vacuolar transport, autophagy, and vacuole biogenesis (PubMed:25624505, PubMed:25699591).  ESCRT component that binds ubiquitin and regulates vacuolar sorting of proteins (PubMed:27495812).  Attenuates abscisic acid (ABA) signaling through RSL1-triggered degradation of the ABA receptors PYR1 and PYL4 (PubMed:27495812).  Interacts with PYL4 and PYR1, and delivers the ubiquitinated ABA receptors as cargo to the vacuolar degradation pathway (PubMed:27495812).  In response to ABA, is phosphorylated by SnRK2 kinases which mediate FREE1 nuclear import (PubMed:30962512).  In the nucleus, interacts with the ABA-responsive transcription factors ABF4 and ABI5 to reduce their ability to bind to their cis-regulatory sequences of downstream genes, thus leading to transcriptional inhibition of ABA signaling pathway (PubMed:30962512).  Negatively regulates salt stress tolerance via a negative feedback loop involving ABA signaling pathway (PubMed:32540007).
What are the official names of this protein?
Protein FREE1, FYVE domain protein required for endosomal sorting 1, FYVE domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome. Endosome, multivesicular body. Nucleus. Note=In response to abscisic acid (ABA), SnRK2 kinases phosphorylate FREE1, a step requisite for ABA-induced FREE1 nuclear import.
Protein: ATPG_GLAP5
Sequence: MAGAKEIRTKIASVRNTQKITKAMEMVAASKMRKTQERMSASRPYSDAIRKVISHIAKGSIDYKHPFLTEREVKKVGFIVVSTDRGLCGGLNINLFKTVLNELKTRKDKGVDSVLGLVGNKAVSFFQSMGVEIKAQVTGLGDTPAMEDLVGIVNGMIENYRNGEVDEVYIIYNRFVNTMSQKPTVQKLLPLPELEDDDLENKGSWDYIYEPNPKVLLDSLLVRYLESQVYQAIVDNLASEQAARMVAMKAATDNAGNLINELQLVYNKARQASITNELNEIVAGAAAI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL3_THEAB
Sequence: MKMIIGRKVGMTRIFKDDKVIPVTVIKAGPCYVVQKKTIDTDGYNAIQIGFEEAKKVNKPMEGVFKKAGVKPLKILKEFRVENPEEFELGQEIKVDIFAEGDKIDITGWSKGRGFAGAMKRWGFRGGPKSHGAKFHRELGSVGQHSEPARIFKGKKMPGQYGNERVTILNSEIVKIDVENNLIAVKGGVPGARGGLVLIRTAKRG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PURA_BRUO2
Sequence: MANVVVVGSQWGDEGKGKIVDWLSERADVIVRYQGGHNAGHTLVIDGVSYKLSLLPSGLVRGKLSVIGNGVVVDPHHFVAEVEKLRGQGIDVTPDVLRVAENAPLILSIHRELDAMREGSNSGLKIGTTKRGIGPAYEDKVGRRAIRVIDLTEPETLRPKVERLLAHHNSLRRGMGLEEIAVETILTELTSVADQILPYIDQVWRVLDERRKAGARILFEGAQGALLDNDHGTYPFVTSSNTVAGQAAAGSGLGPTAIGYVLGITKAYTTRVGEGPFPTELNDEIGEFLGTKGHEFGVVTGRKRRCGWFDAVIVRQTVRTSGINGIALTKLDVLDGLEEIKICVAYKLDGKRIDYLPSSMGAQARVKPIYETLPGWSETTAGARSWNDLPAQAVKYVRHIEELIGAPVAMLSTSPEREDTILVTDPFHD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_HAEDU
Sequence: MSIRPLHDKVILKREEVETCSAGGIVLTGSATVKSTRGKVIAVGTGRLLENGSIQPLSVKEGDMVIFNEGYGAKVEKIDGEEILILSENDILAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCGR4_HUMAN
Sequence: MGCCGCGSCGGCGGRCGGGCGGGCSGGCGGGCGGGCGGGCGSCTTCRCYRVGCCSSCCPCCRGCCGGCCSTPVICCCRRTCGSCGCGYGKGCCQQKCCCQKQCCC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Small cysteine and glycine repeat-containing protein 4, Keratin-associated protein 28-4.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 28 family.
Protein: Y4033_SERP5
Sequence: MSAVTPVLDGLAIRLYIQPKASRDQIVGLHGDELKVAITAPPVDGQANAHLIKFLAKQFKVAKGNVTIEKGELGRHKQLRIVNPQQIPDVVAALIE
What are the official names of this protein?
UPF0235 protein Spro_4033.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: MSMA_METHY
Sequence: MPARNHTQWMATPPLQKGEWVDSRVYTDQEIFDEELEKIFKKAWVPFRHESELPKAYDFRTTSIANEPIIVTRGPDNEVRAFLNVCPHRGMLIERRPSGSLYEGQPSGNPKRMTCMFHAWQFDMKGNCVYISREKEGYQDRLPKESVGLRRLRCEVKFGGFVWVNLDDNPISLEDWAGEPFQCLRKTLEAEPMEVFHYHKAIVDTNYKLWHDTNCEFYHDFMHYHNRVTGFNDAYFARKNESFEHGHILVGTFEVNYDQYEGFESRAGLSFPHLPPNQWYMIDLFPGMNFNLRGSALRCDVVTPLGPNKVMIEFRGLGLKSDTPEERQTRINHHNSIWGPFGRNLHEDLIGVQGQGTTMRPGQESRRILHGRQENQTIHDENGMRHYYDKWGKWMNRMPSNPELPYNAPAIAAE
What is the function of this protein?
Methanesulfonate monooxygenase (MSAMO) mediates the primary degradation of methanesulfonic acid (MSA) to produce formaldehyd and inorganic sulfite by initial hydroxylation of the carbon atom prior to spontaneous cleavage of the unstable hydroxymethanesulfonic acid.  MSAMO has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methane- to butanesulfonate) and excludes all larger molecules, such as arylsulfonates and aromatic sulfonates.  All MSAMO components are required for enzyme activity.
What are the official names of this protein?
Methanesulfonate monooxygenase hydroxylase subunit alpha, Methanesulfonic acid monooxygenase hydroxylase large subunit, Methanesulfonic acid monooxygenase hydroxylase subunit alpha, MSA monooxygenase hydroxylase subunit alpha, MSAMO hydroxylase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_BRUME
Sequence: MSITAERKQALIKEYATKEGDTGSPEVQVAVLSERIANLTEHFKGHKNDNHSRRGLLKLVSQRRRLLDYVKGVDHARYQALITRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RS19_YERPP
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPIRTWSRRSTVFPNMIGLTIAVHNGRQHVPVFVSDEMVGHKLGEFAPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: KPYK_SPOPS
Sequence: MRKTKIVCTIGPASESPELLEQLIEAGMNVARLNFSHGNHAEHKARIDSIRKVAREKGKVVGILLDTKGPEIRTHSMMNGKLELVTGQKIDISMTQVEGNNDVFSVSYDKLIEDVNEGSVILLDDGLIQLEVTGKDVARGLIHTLIINSGSLSNNKGVNIPGVSVQLPGMTEKDAEDILFGIREGVDFIAASFVRRASDVMEIRALLENNNGSNLQIIPKIENQEGVDNIDEILNVSDGLMVARGDLGVEIPPEEVPLVQKNLIEKCNQAGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGIYPVESVQTMDRIALTTEAAIDYRSVVSTRRREKHGNMTEAIGQAAAYTAINLKVKAVLAPTESGHTAKMIAKYRPGCPVIAVTSSEMCSRKLSLIWGVYPIVGKKASSIDEILQESVEESVKHQYVGHGDVVIITAGVPVGEAGTTNLMKIHVIGDLLARGQGIGKDVAYGRTVVAKNAAEALAYDTEGAILVTNASDRDMMPAIEKCAGLITEEGGLTSHGAIVGLSLGIPIIVGVENATELIQHGKEITMDAESGVIYNGHASVL
What are the official names of this protein?
Pyruvate kinase, PK.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PEP-utilizing enzyme family.
Protein: RL7A_HALMA
Sequence: MPVYVDFDVPADLEDDALEALEVARDTGAVKKGTNETTKSIERGSAELVFVAEDVQPEEIVMHIPELADEKGVPFIFVEQQDDLGHAAGLEVGSAAAAVTDAGEADADVEDIADKVEELR
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Hs6, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX16_NEUCR
Sequence: MTFQSKKFPSTANTNTFAAKYRAMMKKHPFLLFGLPFMSVIVAGSFILTPAAAIRYEKYDRKVRQVSREEELGLGQRKRRVDIREEYYRLAAKDLDNWEQKRVERLKGESDGLL
What is the function of this protein?
Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase.  May participate in merging the COX1 and COX2 assembly lines.
What are the official names of this protein?
Cytochrome c oxidase assembly protein cox16, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COX16 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.