PharMolix/UniProtQA huggingface dataset:
Protein: DOPO_HORSE
Sequence: MKVPSPSVREAASMYGTAVAIFLVILVAALQGSEPPESPFPYRIPLDPEGTLELSWNVSYVQETIHFQLLVRELKAGVLFGMSDRGELENADLVVLWTDGDSAYFGDAWSDQKGWIHLDAQQDYQLLRAQRTPEGLSLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFWSLEAINTSALHTGLQRVQLLKPNVSVPALPADMRTMEVRAPDVLVPGQETTYWCYITELPDGFPRHHIVMYEPIVTEGNEALVHHMEVFQCAAEFESFPQFNGPCDSKMKPSRLNYCRNVLAAWALGAKAFYYPEEAGLAFGGAGSSRFLRLEVHYHNPLKIEGRRDSSGIRLYYTATLRRFDAGIMELGLVYTPVMAIPPQETAFVLTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLARDGREREVVNRDDHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRKLATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDPGFLQKYFHFVNRFNGEEVCTCPQASVPEQFATVPWNSFNRQVLSALYGFAPISMHCNRSSAVRFQGDWNLQPLPEIISKLEEPTPRCPASRGRSPAGPTVVDIGGGKG
What is the function of this protein?
Conversion of dopamine to noradrenaline.
What are the official names of this protein?
Dopamine beta-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the copper type II ascorbate-dependent monooxygenase family.
What are the subcellular locations of this protein?
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein.
Protein: COBS_CHLPM
Sequence: MLSGLVSAIRTLTIFSVPGKDAENFSSSLYWFPVVGAFLGTLLAACAWLPLSIGWSELASAVVVVGGFIVSRGMHADGLADMADGFWGGGDRERTLSIMKDPTVGSFGALALLSLMLLKWVAILRLTEHGAFALIASGVLLGRLSQVLLAASLPYARKEGGTASGFVGGAGRTHAAVALALSLMMTLPFFYRDPFLLFLLFGAALTAAALIGFLSMKKIGGITGDVLGAVSEVTELFVWLAAGVAFTAF
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL9A_HCMVM
Sequence: MSLDAASHQPAARRLLDSALVRRVLACMIIVIMIAISIWILTYVLFL
What are the official names of this protein?
Protein RL9A.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: PYRF_AGRRK
Sequence: MTARDRLIVGLDVPNLQEAEKVVSALGDDILYYKIGYQLAFAGGLEFARDLAKDGKKIFLDMKLLDIDNTVASGVENIVKMGMSMLTLHAYPKAMKAAVAAAKGSDLCLLGVTVLTSMDEEDLIAAGYEYDPHTLVLRRAEQALLAGMGGIVCSAEEASAVRKIIGPDMALVTPGIRPAGSDKGDQKRVMTPAEGIRAGSSHLVVARPIVKAADPREAARAILAEMDAAL
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: MSMB_MACMU
Sequence: MNVLLGGFVIFATFVTLCNASCSFIPNERFPGDSTRECTDLKGNKHPINSKWKTDNCERCTCYKTEIICCTLIATPVGYDKKKCQRIFKKEDCKYIVVEKKNPKKTCPIDQWIL
What are the official names of this protein?
Beta-microseminoprotein, Prostate secreted seminal plasma protein, Prostate secretory protein of 94 amino acids, PSP-94, PSP94.
What is the protein family that this protein belongs to?
Belongs to the beta-microseminoprotein family.
What are the subcellular locations of this protein?
Secreted. Note=Sperm surface.
Protein: RS10_ECO81
Sequence: MQNQRIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHLRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: LIPA_SALSV
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVVTERDALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDAEEPQKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIRAKSPEIKIETLVPDFRGRMDRALDILNATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNAEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPEEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FKBA_ECOLI
Sequence: MKSLFKVTLLATTMAVALHAPITFAAEAAKPATAADSKAAFKNDDQKSAYALGASLGRYMENSLKEQEKLGIKLDKDQLIAGVQDAFADKSKLSDQEIEQTLQAFEARVKSSAQAKMEKDAADNEAKGKEYREKFAKEKGVKTSSTGLVYQVVEAGKGEAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPGIPPNSTLVFDVELLDVKPAPKADAKPEADAKAADSAKK
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PTR26_ARATH
Sequence: MASIDEERSLLEVEESLIQEEVKLYAEDGSIDIHGNPPLKQTTGNWKACPFIFANECCERLAYYGIAKNLITYFTNELHETNVSAARHVMTWQGTCYITPLIGALIADAYWGRYWTIACFSAIYFTGMVALTLSASVPGLKPAECIGSLCPPATMVQSTVLFSGLYLIALGTGGIKPCVSSFGADQFDKTDPSERVRKASFFNWFYFTINIGAFVSSTVLVWIQENYGWELGFLIPTVFMGLATMSFFFGTPLYRFQKPRGSPITSVCQVLVAAYRKSNLKVPEDSTDEGDANTNPWKLCTVTQVEEVKILLRLVPIWASGIIFSVLHSQIYTLFVQQGRCMKRTIGLFEIPPATLGMFDTASVLISVPIYDRVIVPLVRRFTGLAKGFTELQRMGIGLFVSVLSLTFAAIVETVRLQLARDLDLVESGDIVPLNIFWQIPQYFLMGTAGVFFFVGRIEFFYEQSPDSMRSLCSAWALLTTTLGNYLSSLIITLVAYLSGKDCWIPSDNINNGHLDYFFWLLVSLGSVNIPVFVFFSVKYTHMKV
What are the official names of this protein?
Protein NRT1/ PTR FAMILY 8.4, AtNPF8.4, Peptide transporter PTR4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GB_HHV11
Sequence: MRQGAPARGRRWFVVWALLGLTLGVLVASAAPSSPGTPGVAAATQAANGGPATPAPPAPGAPPTGDPKPKKNRKPKPPKPPRPAGDNATVAAGHATLREHLRDIKAENTDANFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKYVRNNLETTAFHRDDHETDMELKPANAATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATAPTTRNLLTTPKFTVAWDWVPKRPSVCTMTKWQEVDEMLRSEYGGSFRFSSDAISTTFTTNLTEYPLSRVDLGDCIGKDARDAMDRIFARRYNATHIKVGQPQYYLANGGFLIAYQPLLSNTLAELYVREHLREQSRKPPNPTPPPPGASANASVERIKTTSSIEFARLQFTYNHIQRHVNDMLGRVAIAWCELQNHELTLWNEARKLNPNAIASATVGRRVSARMLGDVMAVSTCVPVAADNVIVQNSMRISSRPGACYSRPLVSFRYEDQGPLVEGQLGENNELRLTRDAIEPCTVGHRRYFTFGGGYVYFEEYAYSHQLSRADITTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVIHADANAAMFAGLGAFFEGMGDLGRAVGKVVMGIVGGVVSAVSGVSSFMSNPFGALAVGLLVLAGLAAAFFAFRYVMRLQSNPMKALYPLTTKELKNPTNPDASGEGEEGGDFDEAKLAEAREMIRYMALVSAMERTEHKAKKKGTSALLSAKVTDMVMRKRRNTNYTQVPNKDGDADEDDL
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress (By similarity).  Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans- Golgi network (TGN).
Protein: GBRB_CAEEL
Sequence: MRRSKTRRIFHVSITLLLVSTIFCQNGTKPHNNSTSDQMSSSWSNRSQTMYSNASSLLSDLLLDYDIRLRPGFGGDALLLTMDIIIASFDSISEVDMDYTLTMYLHQYWTDERLRWSNEIPIDEMTLSGEFSQNIWVPDTFLANDKHSYLHEVTERNKMLRINVDGKVAYGMRLTSTLSCSMNLRNFPLDSQNCTVEIESYGYTTSEVLMKWNYPLAVHGVEQADVPQFTITGFHTEDSIVSTATGSYQRLSLVFQLRRSVGYFIFQTYLPCVLIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRQSLPRISYVKSIDIYLVMCFVFVFAALLEYAAVNYSYWGRERGKGGGGNEWPVNGANKEDRESAVNVQKWVPSGLMDGVPQPQDRRVEALEEAMSTSNTAAQNNNFESTSKPKKRSSSPIPPLCRAGNTISEESESPDYPRYSTTSLKGARPHASLNHKTHHLKGRSSARAKRRMTLARMNVSMKQSISGIGRRARKVIPTIRVRDVNLIDKYSRVVFPVCFIVFNLFYWSYYMMVPS
What is the function of this protein?
GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel.
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit beta, GABA(A) receptor subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RUVC_CORJK
Sequence: MGIDPGLTRCGLSVVQAGKGRAVYPVAVGVVRTPSDMPVEQRLNKLFDAVEQWFDDYQPHVVALERVFERSNVSTVMNTAHASGVLMLAAARRGVDVHMYTPSEVKKSISGNGRADKAQMTRMITRILGLSEAPKPPDAADALALAVCHCWRAPLNHLVKGKL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: FEZF2_MOUSE
Sequence: MASSASLETMVPPACPRAGASPATSKTLAFSIERIMAKTSEPRAPFEPRPAALEADSSQSKKLLNLCSPLPCMIPLQPLGYEVPSKTLLSYSEFWKSSLRAGGGGGGGSGGGAPVCGASGLCKTNCGVCCKAELGLAPSALPAGRVIKPQVINQAVGLPASGSLYYFNYLDSTAYPPSELLGGHLFPSGLLNAQAPTSLAAHPKLFLLENAKLASLAADKFPHPASYPHKERLHAPLEQVLKENSALTAERGGVKSHSKLPGGSTDSKPKNFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTQEKPHKCNQCGKAFNRSSTLNTHIRIHAGYKPFVCEFCGKGFHQKGNYKNHKLTHSGEKQYKCTICNKAFHQVYNLTFHMHTHNDKKPFTCATCGKGFCRNFDLKKHVRKLHDSVGPTATPSAKDLARTVQS
What is the function of this protein?
Transcription repressor.  Required for the specification of corticospinal motor neurons and other subcerebral projection neurons.  May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation.  Controls the development of dendritic arborization and spines of large layer V pyramidal neurons.  Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation.
What are the official names of this protein?
Fez family zinc finger protein 2, Forebrain embryonic zinc finger-like protein 2, Zinc finger protein 312, Zinc finger protein Fez-like.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
Protein: VSPGL_GLOSH
Sequence: MVLIRVQANLLILQLSYAQKSSELIIGGDECNINEHRFLVALYTSRSRRFYCGGTLINQEWVLTAAHCDRKNIRIKLGMHSEKVPNEDAETRVPKEKFFCLSSKTYTKWDKDIMLMRLKRPVNNSTHIAPVSLPSNPPSVDSVCRVMGWGTITSPQETYPDVPHCANINILDYEVCQAAHGGLPATSRTLCAGILKGGKDSCKGDSGGPLICNGQFQGIASWGAHPCGQSLKPGVYTKVFDYTEWIQSIIAGNTDATCPP
What is the function of this protein?
Thrombin-like snake venom serine protease.  The recombinant form clots fibrinogen by cleaving fibrinogen Aalpha chain (FGA), and slowly Bbeta chain (FGB).  Has amidolytic activities.
What are the official names of this protein?
Thrombin-like enzyme gloshedobin, SVTLE, Defibrase, Fibrinogen-clotting enzyme, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1236_STAAM
Sequence: MGQNDLVKTLRMNYLFDFYQSLLTNKQRNYLELFYLEDYSLSEIADTFNVSRQAVYDNIRRTGDLVEDYEKKLELYQKFEQRREIYDEMKQHLSNPEQIQRYIQQLEDLE
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein SAV1236.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: CCND3_BOVIN
Sequence: MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHSVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLALILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSTSGDELTELLAGIAGTEVDCLRACQEQIEAALRESLREAAQTSPSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
What is the function of this protein?
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.  Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.  Hypophosphorylates RB1 in early G(1) phase.  Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.  Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.  Shows transcriptional coactivator activity with ATF5 independently of CDK4.
What are the official names of this protein?
G1/S-specific cyclin-D3.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin D subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: DCMC_RAT
Sequence: MRGLGPSLRARRLLPLRYPPRPPGPRGPRLCSGLTASAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAEAAQRAELLGRLAQGFGVDHGQVAEQSAGVLQLRQQSREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPHVREMNGVLKSMLSEWFSSGFLNLERVTWHSPCEVLQKISECEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGDPLVVLHVALTGDISNNIQSIVKECPPSETEEKNRIAAAVFYSISLTQQGLQGVELGTFLIKRVVKELQKEFPHLGAFSSLSPIPGFTKWLLGLLNVQGKEYGRNELFTDSECKEIAEVTGDPVHESLKGLLSSGEWAKSEKLAQALQGPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVMWRINWMADSSLKGLTSSCGLMVNYRYYLEETGPNSISYLGSKNIKASEQILSLVAQFQSNSKL
What is the function of this protein?
Catalyzes the conversion of malonyl-CoA to acetyl-CoA.  In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced.  In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids.  Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling.  May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.
What are the official names of this protein?
Malonyl-CoA decarboxylase, mitochondrial, MCD.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion matrix. Peroxisome. Peroxisome matrix. Note=Enzymatically active in all three subcellular compartments.
Protein: CD47_HUMAN
Sequence: MWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILLFWGQFGIKTLKYRSGGMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFVASNQKTIQPPRKAVEEPLNAFKESKGMMNDE
What is the function of this protein?
Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453).  Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835, PubMed:8550562, PubMed:7691831).  Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:27742621, PubMed:19004835, PubMed:8550562, PubMed:11509594, PubMed:7691831, PubMed:32679764, PubMed:15383453).  Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621).  Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity).  Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity).  Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (PubMed:11509594).  Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (PubMed:15383453).  Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity).  Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764).  In response to THBS1, negatively modulates wound healing (By similarity).  Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity).  May play a role in membrane transport and/or integrin dependent signal transduction (PubMed:7691831).  May prevent premature elimination of red blood cells (By similarity).
What are the official names of this protein?
Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Protein MER6.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YONJ_BACSU
Sequence: MIDPVQTKRHSDENLKEWKIRICSNKDIYNLNWEEIKELINKETGESKGESAYRKWFNNFIEGVEYQRERSDESNNSLLELELKKVEIMEERKKLQAVKHEIHKNTRVKGRTELLYENVTEAIEKVGTLPPPSFYPLNKNERKRAAVLGFGDEHFGKQFKSNNNEYNEQIYLQRMNQILSETVEYIQKENLDELVVLNGADSVEGMALRVSQLTALQYGFIDQVIKYSRYKAEWLLELSKHVKIKYIHIPSANHTELRLHNTNRSEMPKEDVERIIATYIHDVLKDNERIEVPLYDEGIVDFKLLEFEIVACHGHQIKNKKNAIRDISQMKRKFYDYMYISHFHHGNMLTVGEAATHNIQVIQLPSVMGSDEYSDSLMTGAKAGANLSIYESGKGRIIQYDYILN
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YonJ.
Protein: RSMA_MACCJ
Sequence: MEYNDIATPTRTKQLLDQYGFKFKKSLGQNFLVDTNVIRNIIEAAGIDKTSGVIEIGPGMGSLTEQLAKHAKQVLAFEIDQRLIPILGETLSPYDNVTVINEDILKADVASAIETYLHHCDEIFVVANLPYYITTPILMGLLEKNLNINSYVVMMQKEVGERLSAIPSTKAYGSLSIAVQYYTDVKRIMVVPKGVFMPPPNVDSLVVKLTTLERPRVDVEDENLFFKLTRGAFVQRRKTILNNYMSLIQDSKEHKSRIIEWLEASGVAPSRRGESLNLNDYAQLSNNMKKYPELVI
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_LEPBL
Sequence: MIICRTPEEISVQVRRWKAEDKKVGFVPTMGYLHEGHASLFRECLSKADKTVVSIFVNPAQFNDPEDYAKYPINTDGDLKICESGKVDLVFLPEKETIYPEGIPNVVLQVPHLMRNLCAVSRPGHFEGVLLVISRLFHFVKPDFAFFGKKDYQQYLLVKEFCKILAFPVEVIGCETIRSDKGLALSSRNSRLSEDEKEESLLISRALKLGEAQILSGIKDPVVVRDIMKDVLDSSPKIRLDYLEVLNADTLESLEILEGNILLAAAVFIGSVRLIDNRTLRVASV
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE2_GLUDA
Sequence: MKLRFAPSPTGLIHVGNARQAIANALYARRHGGTFQLRIDDTDRERSRDEYVDALHTDLAWLGITWDETFRQSDRLDRYAAAIETLKASGRLYPCFESEQELASKREARIRMRKPPIYDRAMLRMTAEQRAQAEANGKVPYWRFRLSDQDRGVDDMVMGRSQVKLQSISDPVLVRADGTVLYTLASVVDDMETGVTHVLRGEDHLTNTGVQIDIAEALGGKVGQFAFAHLPLLLDEAGGKLSKRFDGLSIRALRQDGIDPVAIVSYLARLGSADDPAPLSFDDLAASYDVRRVSRSAARFDMRQLLALNRRVMHQMPFGAIRDRLPEGATEAFWMAVRGNVDMVSELRHWWDVVGGVIVPPVQDDEGAYLLQALALLPPEPWDAQTWKDWTTAVRDATGRSGKSVFHPLRVALTGEEEGPEMRDLLPLMGHDRVAERLRIAAR
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIB2_ARATH
Sequence: MAPLNSQAAGEEESNYQCRFPRFMHLSWKRPYLTRVFDLAVIQKKQKKEMSDSEEKKCNDDSKQPVLVLDLLRSILERLSFVDFHRGRCISLEWYSASESCLAVKNPTSPWIILFPSENVESKNDSCKLYNPRDHSSYIVRDLGFDLARSRCLASSGSWFLMLDHRTDFHILNLFTRVRIPLPPLESTGDGNVFKRVYENVSDGSCIKIDNAVLWVDEKRRDYLVVWNISRLFGYHKKGDENYSWKVFKPLKKNDCCIDMAFKENKLYVLSVTRKVTVYDFSGGDSPVKCATFPSLRFRNGYSYNTQGCHYKVAVTLSGEVLIIVAKVEPYPRVECFFAVYKMDHNSSGYERISLGGEALLLDLGITVEANCMKNCIYFSNDQFHRYNGKSLCDDSNKNGICVYHIRSRYVVQVFEHLTASSKIAFKDARSFFPIFGGKWLL
What is the function of this protein?
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.  Required for brassinosteroid (BR) signal transduction.  Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e. g.  BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation.
What are the official names of this protein?
F-box protein KIB2, Protein KINK SUPPRESSED IN BZR1-1D 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus.