PharMolix/UniProtQA huggingface dataset:
Protein: FPPS_MOUSE
Sequence: MNGNQKLDAYNQEKQNFIQHFSQIVKVLTEKELGHPEIGDAIARLKEVLEYNALGGKYNRGLTVVQAFQELVEPKKQDAESLQRALTVGWCVELLQAFFLVSDDIMDSSLTRRGQICWYQKPGIGLDAINDALLLEASIYRLLKFYCREQPYYLNLLELFLQSSYQTEIGQTLDLMTAPQGHVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANALKILMEMGEFFQVQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLLRASPQQRQILEENYGQKDPEKVARVKALYEALDLQSAFFKYEEDSYNRLKSLIEQCSAPLPPSIFMELANKIYKRRK
What is the function of this protein?
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones.  FPP also serves as substrate for protein farnesylation and geranylgeranylation.  Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity).
What are the official names of this protein?
Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Cholesterol-regulated 39 kDa protein, CR 39, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIGA_STRGR
Sequence: MSASTSRTLPPEIAESESVMALIERGKADGQIAGDDVRRAFEADQIPPTQWKNVLRSLNQILEEEGVTLMVSAAESPKRARKSVAAKSPVKRTATKTVAAKTTVTRTVAATAAPAVESADAADDAVAAAPAKKTAAKKATAKKAAAKKTTAKKTAAKKSGKQDDEILDGDEAAEEVKAGKGEEEEGEGENKGFVLSDDDEDDAPAQQVAVAGATADPVKDYLKQIGKVPLLNAEQEVELAKRIEAGLFAEDKLANADKLAPKLKRELEIIAEDGRRAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLARVQRQMLQDLGREPTPEELAKELDMTPEKVIEVQKYGREPISLHTPLGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHSVLDTLSEREAGVVSMRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA, RNA polymerase principal sigma factor HrdB.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPM1_SCHPO
Sequence: MSKYSVLLPTYNERKNLPIITYLIAKTFDQEKLDWEIVIIDDASPDGTQEVAKELQKIYGEDKILLKPRSGKLGLGTAYIHGLKFATGDFVIIMDADFSHHPKYLPEFIKLQKEHNYDIVLGTRYAKDGGVYGWNLKRKFISRGANLLASTVLGTGVSDVTGSFRLYKKPVLETLMSEVTSKGYVFQMEIIARAREHNYTIGEVPIAFVDRLYGESKLGMDDILGYLKGVFSLLFI
What is the function of this protein?
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.
What are the official names of this protein?
Dolichol-phosphate mannosyltransferase, Dolichol-phosphate mannose synthase, DPM synthase, Dolichyl-phosphate beta-D-mannosyltransferase, Mannose-P-dolichol synthase, MPD synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: DER_STRGC
Sequence: MALPTIAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYATADWLNRKFSIIDTGGIDDVDAPFMEQIKHQAEIAMDEADVIVFVVSGKEGITDADEYVARMLYKTHKPIILAVNKVDNPEMRNEIFDFYALGLGDPFPVSSVHGIGTGDVLDAIVENLPNEEVAENPDMIKFSLIGRPNVGKSSLINAILGEERVIASPVAGTTRDAIDTVFTDSEGQEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVLNAEEGIREYDKRIAGFAHEAGKGIVIVVNKWDTLEKDNHTMKDWEADIRDQFQYLSYAPIIFVSALTKQRLHKLPDMIKQISQSQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKPPTFVIFVNEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PANC_CHRVO
Sequence: MEIIRTVAEMRAWRKQAGKLAFVPTMGNLHEGHLKLVAAARERAEKVVVSIFVNRLQFGQGEDFDAYPRTFDADCAKLAAAGVDALFFPSERELYPRVRQDFNVEPPHIQNELCGAFRPGHFRGVATVVTKLFNIVQPDLACFGKKDYQQLHVIQAMIADLNSPIEIVPVDTGRAGDGLALSSRNGYLSAEERAEAPRLYRNLSMIRDGLMAGSQDYAALEQAARDDLAAAGWTVDYVEVRQADTLEIAHAGEKRLVVLAAARLGKTRLIDNIEVFR
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPPH_SALPA
Sequence: MIDDDGYRPNVGIVICNRQGQVMWARRFGQHSWQFPQGGINPGESAEQAMYRELFEEVGLSRKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFLLQLMSADAEINMQTSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFASVVMALQDNPPKLQSAPAYRRKRG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: TM154_HUMAN
Sequence: MQAPRAALVFALVIALVPVGRGNYEELENSGDTTVESERPNKVTIPSTFAAVTIKETLNANINSTNFAPDENQLEFILMVLIPLILLVLLLLSVVFLATYYKRKRTKQEPSSQGSQSALQTYELGSENVKVPIFEEDTPSVMEIEMEELDKWMNSMNRNADFECLPTLKEEKESNHNPSDSES
What are the official names of this protein?
Transmembrane protein 154.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SIFA_AGRIP
Sequence: MRFIVALCLFAIVMCIIHKAEGTYRKPPFNGSIFGKRGVVEYDTTGRALSALCEIASETCQAWYQTLENK
What is the function of this protein?
Ligand for the neuropeptide SIFamide receptor.
What are the official names of this protein?
Neuropeptide SIFamide, SIFa, TYRKPPFNGSIF-amide.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: DEFA1_HORSE
Sequence: MRTLTLLTALLLLALQVQTQSLEETADQVPAQDQPGAEAQDITISFAGDERSAREASKSLIGTASCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR
What is the function of this protein?
Has broad-spectrum antimicrobial properties (PubMed:17620056, PubMed:19211153).  The antimicrobial activity decreases in the present of salt in vitro (PubMed:19211153).  Binds anionic phospholipids, which leads to the aggregation of liposomes in vitro (PubMed:25769951).  Membrane permeabilization of the target cells is an essential part of the peptide's mode of antimicrobial activity (PubMed:17620056, PubMed:22232283).  No hemolytic activity against sheep or horse erythrocytes (PubMed:22232283).  Has antibacterial activity against the bacterial horse pathogens Gram-positive R. equi ATCC 33701 P(-) (minimum bactericidal concentration or MBC=5 ug/ml) and R. equi ATCC 33701 P(+) (MBC=5 ug/ml), which are resistant against beta-lactam antibiotics.  Also has antibacterial activity against highly infectious wild-type strain R. equi 85F P(+) (MBC=5 ug/ml), S. equi subsp.  equi (MBC=5 ug/ml), S. equi subsp.  zooepidemicus (MBC=5 ug/ml), S. dysgalactiae subsp.  equisimilis (MBC=10 ug/ml), S. choleraesuis subsp.  choleraesuis serovar Typhimurium (MBC=10 ug/ml), and P. multocida subsp.  multocida (MBC=>10 ug/ml) (PubMed:19211153).  Probably contributes to the antimicrobial barrier function of the small bowel mucosa (Probable).
What are the official names of this protein?
Alpha-defensin 1.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: COSA_ORYSI
Sequence: MNVEEEVGKLKEEIQRLGQKQPDGSYKVTFGVIFNDDRCANIFEALVGTLRAAKKRKIVKYDGELLLQGAHDNVEITLLPPPAVAAA
What are the official names of this protein?
Costars family protein.
What is the protein family that this protein belongs to?
Belongs to the costars family.
Protein: COX17_HUMAN
Sequence: MPGLVDSNPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
What is the function of this protein?
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase.  Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
What are the official names of this protein?
Cytochrome c oxidase copper chaperone.
What is the protein family that this protein belongs to?
Belongs to the COX17 family.
Protein: GMPP1_ARATH
Sequence: MKALILVGGFGTRLRPLTLSFPKPLVDFANKPMILHQIEALKAVGVDEVVLAINYQPEVMLNFLKDFETKLEIKITCSQETEPLGTAGPLALARDKLLDGSGEPFFVLNSDVISEYPLKEMLEFHKSHGGEASIMVTKVDEPSKYGVVVMEESTGRVEKFVEKPKLYVGNKINAGIYLLNPSVLDKIELRPTSIEKETFPKIAAAQGLYAMVLPGFWMDIGQPRDYITGLRLYLDSLRKKSPAKLTSGPHIVGNVLVDETATIGEGCLIGPDVAIGPGCIVESGVRLSRCTVMRGVRIKKHACISSSIIGWHSTVGQWARIENMTILGEDVHVSDEIYSNGGVVLPHKEIKSNILKPEIVM
What is the function of this protein?
Essential protein during embryogenesis (PubMed:15266054).  Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.  Plays an essential role in plant growth and development and cell-wall architecture.  Provides GDP-mannose, used for cell wall carbohydrate biosynthesis, protein N-glycosylation, as well as for the biosynthesis of the antioxidant ascorbate.
What are the official names of this protein?
Mannose-1-phosphate guanylyltransferase 1, GDP-mannose pyrophosphorylase 1, Protein CYTOKINESIS DEFECTIVE 1, Protein EMBRYO DEFECTIVE 101, Protein HYPERSENSITIVE TO AMMONIUM ION 1, Protein SENSITIVE TO OZONE 1, Protein VITAMIN C DEFECTIVE 1.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DBP10_VANPO
Sequence: MGIISKRKRHVEDSNSSSDDDDGFDITSNIGLNTADSSDESESSGDDEEEVQDIVDFSDEEDTKKKPKSSNKTLTDNNSFPSLEISDDEDSNNKGDHEDDDDDLNDYFSINNSEKSKHKKGSFPSFGFSKLILSNVHKKGFRQPTPIQRKTIPLILQKRDIVGMARTGSGKTAAFVLPMIEKLKSHSSKIGARAVILSPSRELALQTHRVFKEFSKGTHLRSVLLTGGDSLEDQFSMMMSNPDVIVATPGRFLHLKVEMSLDLKTVEYVVFDEADRLFEMGFQEQLNELLAALPMNRQTLLFSATLPSSLVDFAKAGLTNPVLVRLDAETKISENLEILFLSTKNEERENNLLYLLQDVIKIPLGTDDQIKKLSDFNKSLSDSDSEDEDNKGKQNSRKSKKGKFQKLKVSASNELPTEKSTIVFAPTRHHVEYITQLLKDSGFLVSYLYGTLDQHARKRQLLNFRAGLTSILVVTDVAARGVDIPMLANVINYSLPASSKIFIHRVGRTARAGNRGWAYSIVSETELPYMLDLELFLGKKILLTSMYEASCKLMKSKWIADGNTESSFEDPKISYTNRLVLGSAPRYDIESVGDLYKNIIESNFDLQMAKKVSLKAEKLYCRTRTAASPESIKRSKEVIASGWDEQNIRFGRNLEKEKLNFLAKFQNRRNKETVFEFGKNPNDDTAILMQKRRKQIAPIQRKARKRQELLDKERVAGLTHKIEDEILKGEDHEAGYSVPEEALKSFEDADKILEEQESSRKKKSKTFRDPNFFISHYAPAGDIQDKQLQITSGFTNDAAQAAYDLNDDDKVQVHKQTATVKWDKKRKKYVNMQGIDNKKYIIGESGQKIPASFKSGKFAEWSKSRNIKGIKTGARETSIPTNLLSDPTTDSGSQRGPGGRFKHKQNKAPRLPDKFRDDYQSQKKKVQSAIERGVSVKGFGGSSGNTELKTTAQIRKERMAKEKKRQKNARPTKKRKF
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP10.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: IF4G2_ARATH
Sequence: MQQQGEPSVLSLRPGGGGGKSRLFVPRFSSSSSFDLTNGGSEETPFPVKRENSGERVRFSREEILQHRESVQVSDEILRRCKEIAVELFGEEQSWGNHAAESKITNHTQHRHTETDNRDWHSRSQIPTSGKEWLRDDPREAKSTWQGSGPTPVLIKAEVPWSAKRGALSDKDRVVKSVKGILNKLTPEKYELLKGQLIDAGITSADILKEVIQLIFENAILQPTFCEMYALLCFDINGQLPSFPSEEPGGKEITFKRVLLNNCQEAFEGAGKLKEEIRQMTNPDQEMERMDKEKMAKLRTLGNIRLIGELLKQKMVPEKIVHHIVQELLGDDTKACPAEGDVEALCQFFITIGKQLDDSPRSRGINDTYFGRLKELARHPQLELRLRFMVQNVVDLRANKWVPRREEVKAKKINEIHSEAERNLGMRPGAMASMRNNNNNRAAVSGAADGMGLGNILGRPGTGGMMPGMPGTRVMPMDEDGWEMARTRSMPRGNRQTVQQPRFQPPPAINKSLSVNSRLLPQGSGGLLNGGGRPSPLLQGNGSSSAPQASKPIPTVEKPQPRSQPQPQPQAAPLANSLNAGELERKTKSLLEEYFSIRLVDEALQCVEELKSPSYHPELVKETISLGLEKNPPLVEPIAKLLKHLISKNVLTSKDLGAGCLLYGSMLDDIGIDLPKAPNSFGEFLGELVSAKVLDFELVRDVLKKMEDEWFRKTVLNAVIKSVRECPSGQSVLDSQAVEVEACQSLL
What is the function of this protein?
Plays a role in the accumulation of some potyvirus during viral infection.
What are the official names of this protein?
Eukaryotic translation initiation factor isoform 4G-2, eIF(iso)4G-2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4G family.
Protein: SYG_LYSSC
Sequence: MANKSMETIVSLAKHRGFVFPGSEIYGGLANTWDYGPLGVELKNNIKKAWWQKFVQESEHNVGIDAAILMNPKAWVASGHVGNFNDPMIDCKSCKARHRADKIIEDAALAKGDEIIVDGMTFDQMKETMIKYDVVCPDCGKADFTDIRQFNLMFKTFQGVTESSTNEIFLRPETAQGIFVNFKNVQRSMRKRTPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGEDLEWHSYWKEFCKNWLLNLGMKEDSMRLRDHEDDELSHYSNATTDIEFKFPFGWGELWGIADRTDYDLKQHMEHSGEDFTYIDPVSNDRYIPYCIEPSLGADRVTLAFLCDAYDEEELEGDDKRTVLRFHPAIAPFKAAVLPLSKKLSDEATDVWAELRKAFPVDFDESQSIGKRYRRQDEIGTPFCITYDFDSKEDGQVTVRHRDSMTQERMPISEVKAYIEKHLQF
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_I79A4
Sequence: MKAKLLVLLCALSATDADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCRLKGIAPLQLGKCSIAGWILGNPECESLFSKKSWSYIAETPNSENGTCYPGYFADYEELREQLSSVSSFERFEIFPKERSWPKHNVTRGVTASCSHKGKSSFYRNLLWLTEKNGSYPNLSKSYVNNKEKEVLVLWGVHHPSNIEDQKTIYRKENAYVSVVSSNYNRRFTPEIAKRPKVRGQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGIITSNASMDECDTKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSTKLRMVTGLRNIPSIQSRGLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLEKRMENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCNNECMESVKNGTYDYPKYSEESKLNREKIDGVKLESMGVYQILAIYSTVASSLCLLVSLGAISFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: LSPA_CHLCV
Sequence: MSSRSRSTFLAISFFVLIDWVSKLAVLLYRGNLPDARPILYQYSWGKLIFCICPTFNEGAAFGIFSKYKYFLFAIRIAIILGILAFLFLRKKRTSPSIRFSLILLCSGAIGNVGDILFYRHVVDFISIGFKRWYFPTFNFADIFISLGTFIFVYKLYFPTKQKIK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSC1_SCHPO
Sequence: MSSKIRPSADDKKLQRVLYFFLERVRAAKDVSGQLLSPLIDNASVDTASVSPSSNGRPTTLKSIQSKIDEFQYHDFSEFVSDLAYLFINVKALYEGTQTYSFVQALEEFCIQQLRTFQQQGYIPVITWPNTDSPSATTSSPISRNPEYSVSPPNGSKFVKNEDEAYDSDLYVEEEDSDVKGRSMVGRDGRYKSEDLKRRKLQPSSKPLSSLEARAKVIMRQVRRYRDGSGRQLFAPFERLPDPRMFPEYYQAIEQPMALEVIQKKLSKHRYETIEQFVDDFNLMFDNAKSFNDPSSQVYRDADFLKNYLADVLRLEAGKLDSEFFNYETDSRASPQLPKNDIQPAVSIDGTLLNVGDWVLIRNPADSSKPIVSQIYRIWKSDDDINYVTVCWYLRPEQTVHRADAVFYENEVFKTSLYRDHPVSEIVGRCFVMYITRYIRGRPKGIRSTPVFVCESRYNDDTKQFSKIKSWKACMPQEVSGSEYEMILFDRPITLTKVASPLLHLLASKSQGLPSPATTDSNTHMLPSQGSLLPPSSISETKSFSTKASTPLSTDDIATPLSSAPNPPSVMPTYARKTSSHSERSSHSSYHNSSHVPTAAFNSPIMRTSTKSTSPIPARPFYAQSGSLQSLNTTQHSHQISGGHSGRMNVPYAKLSYTSHNGRHGGSNGNISGAKTPMTNYTINSMPSLPVFPPAFIVPGTHQKLDESSPVPGIDDVTVINTETAKMLDKDEHQNVLWYTVPPLDPIPLENRNGSLTHSVEYVLYKKSKGSQVITEKARSNELSREAKFENLVASLSDALIPP
What is the function of this protein?
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning.  Controls particularly membrane and organelle development genes.
What are the official names of this protein?
Chromatin structure-remodeling complex subunit rsc1, RSC complex subunit rsc1, Remodel the structure of chromatin complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the RSC1 family.
Protein: ICFG_SYNY3
Sequence: MKMKLIQPFIQSIRFRIVGLLLLCLIPPTLGGIFLIDSYTGRQLKKIAEQDLQSRARLIIQLISRSDRERQQSTAFVASQPAIVEFNVEASQYFLNEFIKFHQWNGFFVVANQEGELVAGSDGANQEKGLPLKHWFEEVKDKNRHLNRLFPGKTYAESKDCLIVPIHSKNDQTQIGIVVECIPLPVIADFVQKILKDAELERILLVNYEGYIYADTDFKNYGVLENKKKSPLVNRLLNDQSGFVYSQGKFSYLSPVHLRGAKTWGLIVENSESDIQAAILNVNRIGYLLVLVIGGIVAYASWMVIHHSTVPILDLTKASQAIAAGDLDYEININQGNRQDEIGILGNSFIYMKNQIKTLIAQEVKDGVNRLELEKGRQIQQNFLPISLPDLQQWQINAVFEPARSVSGDFYDAFLLGDDYLAIVIGDVCDKGVGAAMFMGLFRSLLRVFSGETMPGDTCIRDVNYKCSANDGNGKKKVIVQFLNAVRLTNDYIATEHGDMAMFATLFFGVIDISNGNLSYINAGHEPVFILNSEGIKHRLKSTGPAVGMMPNSTFTIDSLKIDPGEMLIGYTDGVTDARSPTKEFFGRQRLMETLTANFSAKTEILDIIKQELIGHIDGSIQFDDITMIAVYRN
What is the function of this protein?
Involved in cross-regulation of inorganic carbon and glucose metabolisms.
What are the official names of this protein?
Protein IcfG.
Protein: GRPE_LEGPH
Sequence: MMSKQNKKDWKKFKDEHKEEHKVENEILEEETDEESQHQEPALGHPSYTALEEQLTLAEQKAHENWEKSVRALAELENVRRRMEREVANAHKYGVEKLISALLPVVDSLEQALQLADKNSDPSMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPPNSVITVFQKGYKLSDRVIRPARVIVSTK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTXL_ANDAU
Sequence: MCIPCFTTNPNMAAKCNACCGSRRGSCRGPQCIC
What is the function of this protein?
Toxin with unknown function in healthy organisms.  On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells.  This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity).  Inhibits migration and invasion of U87 glioma cells expressing CLCN3/ClC-3 voltage-gated chloride channels.
What are the official names of this protein?
Chlorotoxin-like peptide AaCtx.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYS_LACDA
Sequence: MLDIKVIRENLDWAKEKLATRGIKPEQLDELVAIDAKRREAMVKCENLKAERNEVSKKIAAAKREKADASEAIANMREVGVKIKELDQEVDELQEKQEYILLRLPNFPADSDPIGPDESYNEEVRRWNEPTKFDYQPKAHWDLGTDLNILDWDAASKVSAARFVYYKGAGALLERAVYNFFLDENTSEGYTEVITPSLVNNDSMQGTGQFPKFTEDVYTIVDNDDPEVARNLTLIPTAEVPLVNYFRGDIIDGKNLPINVTALSPAFRSEAGSAGRDTRGLIRMHEFRKVEMVKVVKPEDSWKELENLTHNAEHLLQKLGLPYRVVALSTGDASFTSAKTYDLEVWMPAQDTYREISSCSNCTDFQARRAQIRYRDEDGKVKLTHTLNGSGLAVGRTVAAILENYQNEDGTVTVPEALRPYMHGMTKITPEVKWH
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFS55_MYCTO
Sequence: MRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMNSVGIPINQLHRITWIVTMYLLGYIAAMPLLGRASDRFGRKLMLQVSLAGFIIGSVVTALAGHFGDFHMLIAGRTIQGVASGALLPITLALGADLWSQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLLHDWRDVFWINVPLTAIAMVMIHFSLPSHDRSTEPERVDLVGGLLLALALGLAVIGLYNPNPDGKHVLPDYGAPLLVGALVAAVAFFGWERFARTRLIDPAGVHFRPFLSALGASVAAGAALMVTLVDVELFGQGVLQMDQAQAAGMLLWFLIALPIGAVTGGWIATRAGDRAVAFAGLLIAAYGYWLISHWPVDLLADRHNILGLFTVPAMHTDLVVAGLGLGLVIGPLSSATLRVVPSAQHGIASAAVVVARMTGMLIGVAALSAWGLYRFNQILAGLSAAIPPNASLLERAAAIGARYQQAFALMYGEIFTITAIVCVFGAVLGLLISGRKEHADEPEVQEQPTLAPQVEPL
What is the function of this protein?
In association with lipoprotein LprG probably transports triacylglycerides (TAG) across the inner cell membrane into the periplasm; TAG probably regulates lipid metabolism and growth regulation.  May be an efflux transporter and involved in maintaining correct cell wall permeability.  Probably required with LprG for normal surface localization of lipoarabinomannan (LAM).
What are the official names of this protein?
Probable triacylglyceride transporter MT1454, MFS-type drug efflux transporter P55.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL21_NITWN
Sequence: MFAVIKTGGRQYRVVPDDVLEIGKIAGEVGTIVQLGEVLVLGGDTPVLGAPTVAGASIAAEVLQHKRGPKVIAFKKRRRKHSKRKRGYRDEITVLRVTEILADGKSPTIGPRPKKEKAVEPVEGASDDKPRRAAKKTAAKTAEDAD
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: MNHG1_STAAT
Sequence: MIKIILISLALIFVIIGALISALAAIGLLRLEDVYSRAHAAGKASTLGAMSLLFGTFLYFIATQGFVNMQLIVAIIFVLITGPLSSHMIMKAAYNIKTPYTKKTKVDEISEDLKDTKL
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit G1, Mnh complex subunit G1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ANF_ANGJA
Sequence: SKSSSPCFGGKLDRIGSYSGLGCNSRK
What is the function of this protein?
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation.  Has a cGMP-stimulating activity (By similarity).
What are the official names of this protein?
Natriuretic peptides A, Prepronatriodilatin.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.