PharMolix/UniProtQA huggingface dataset:
Protein: ELK4_HUMAN
Sequence: MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDVENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKSPQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPTSASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEPKDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQTPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT
What is the function of this protein?
Involved in both transcriptional activation and repression.  Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression.  Forms a ternary complex with the serum response factor (SRF).  Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.
What are the official names of this protein?
ETS domain-containing protein Elk-4, Serum response factor accessory protein 1, SAP-1, SRF accessory protein 1.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: T161A_XENTR
Sequence: MAIMGVQMVVTLLVASIMQRVSPHYSFGRWLLCNGSLFRFKHPTEEELRTLAGKQKPKAKRERRTNGVTDEKPLTVPKDIDLRLDTQPITTIDALVLRYFLEYQWFIDFALYSTIIYLFTEAYYCVVDAQNEINIGVLWCLMSIIFSIKVLFTVMKHYFRSEEGGERSVCLTFAFFFLLIAMIVMVVRDEYLEFGLEPGLASVCHNLENFLAQRGWQWSMPFVKLAFKIALVALCAFLGGCLTFPGLRLAQTHLDALKMAADRPMLQLLLHMSFLPPVIVVVLWIRPITRDFLLNAPMGKESVELMSNSAYNTFRLWIIVVLCLLRFCLTRFHLQAYLCLADRWVEQMKREAGRISMLEIQRKISRIFCYLTVVALQYLAPIVLTFHCVLMLKSLGDYSWGLYPEPTGFTPVVDSSPVQSHSPTSEEEEDTEDVQAAVEQIMGAMSSLRGLFTPLFFRGLFSFLTWWVSVCQIVTSLFGLYFHQYLGAS
What is the function of this protein?
May play a role in protection against oxidative stress.
What are the official names of this protein?
Transmembrane protein 161A.
What is the protein family that this protein belongs to?
Belongs to the TMEM161 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LEU3_SALRD
Sequence: MDDTRSYDIAWLPGDGIGPEVTREALRVLEAVGSAHGFSVTATEHRMGGVALDETGMPLPDSTRDACLESDAVLLGAVGGPKWADNTGDQRPESGLLALRKALGVYANLRPVRVPAALADASPLRPDRVGGTDILFVRELTGGIYFGTPEGRTDDGARSTMAYSDDEIERIAHVAFQRARRRDGNVTSVDKANVLEVSELWREVVTEVHDDCPDVTLRHLYVDNAAMQVVRDPRQFDVVLTGNLFGDILSDLAAALPGSLGLLPSASVGGTVGLFEPVHGSAPDIAGQDVANPTAAILSAALLLDEVGETAAADAVRHGVDAALDAGFRTADLAADNEEDASTSAFGREVATRAADSVPQNAPTP
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBC1_MIMIV
Sequence: MNSSNIRRIQNEYNKINNDKNLYADSFQINMVDENIFLWKVNIKGPENSLYENYNFELEIELSNDYPYSSPKVKFITPIQHMNVNDKGDICLNILKKDGWNASLNIISIIWSIIVLLDQPNPEDPFNSELASLYRNDKLSYDKKIRDYCKTHSKLWTF
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.
What are the official names of this protein?
Probable ubiquitin-conjugating enzyme E2 L460, E2 ubiquitin-conjugating enzyme L460, Ubiquitin carrier protein, Ubiquitin-protein ligase.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: SWS1_SCHPO
Sequence: MQQGHFTSNSYHSKTLNSSSLPVSSKFSHTNDPDVEGVDNDSFSKALCNKDLDPSSTIRSVISSLLDSLQDKALQQSPNTSLSKLLLEDQDFGSLWLSLSFIFCNYWQPAMLILDSKSIHPLPLTDGEVLHRWECEVDSNNKTTIDLKYWYCSCSQFSYNAFNSSRSFDEPMPKNEQETWGGRCLSHHPTICSHILAASILRACHNLVI
What is the function of this protein?
Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
What are the official names of this protein?
Zinc finger SWIM domain-containing protein sws1, SWIM domain-containing and srs2-interacting protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm.
Protein: TRPD_MYCBP
Sequence: MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RL15_ECO27
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEVRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL27_CLOK1
Sequence: MIIMNLQIFAHKKGMGSSKNGRDSESKRLGTKSADGQFVLAGNILVRQRGTKIHPGKNVGRGSDDTLFSKIDGIVRYERFGKTKKKASVYPLEVEELVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: CCM1_YEAS8
Sequence: MYMARCGPKNNVLCFPFQLSFLFSKRLINKRFKYTLQTEDEKDMMGSLSKNKIITPEDVEFKLAQLREFSNTLKERIHNTKSVNSDGHQSNSIAPISEDSRNVNVTKISSVPNEEKSKNLSDLIHSSFLEKMDHLVPKVIRERVADDDILAKNLFDRSHSNWAPVIDRLYVSEKRFMDIDSREFSVWLNGTVKYLPFHSILHLDEMLLEQINGDVVKFNTHMYECIFNNLGNLKPTNFNQDGTNDKVILKMKELLERYDKALKITEERINKKEGFPCKVPKMTQAILNNCLKYSTKCSSFHDMDYFITKFRDDYGITPNKQNLTTVIQFYSRKEMTKQAWNTFDTMKFLSTKHFPDICTYNTMLRICEKERNFPKALDLFQEIQDHNIKPTTNTYIMMARVLASSSSNAVVSEGKSDSLRLLGWKYLHELEDKNLYRHKKDDLNSFLAMMALAAFDGDIELSRALYYLFIAKKYKTLCANWKGNILVDQDTIWKSTLMPEMLNYLMLAYARFDPRNLPVLSGYEKGIELRRKFLREFDSSMRLDDTDKLVKFKLPFLPISDLNSEAQVLAESNAIWSFNLENGGTRNTLTSSNEAALEDIKKYRQLLDSFAQEAEDFNEFKFKVMYEVTKMQRESINVNVFNKISLHTYLSIPINLKQQKEFLRRLTFFTFQQHEFEAVIKRLYEGYRNIPSSHTRDQNSISTEAISVSKPETTEDLNLIMHDIWYITCLRHKIMMDTTLYELVMKAAIEFQNEDLAKKVWNDRGKFRTTVPFLKMDQRIRIAKDQKFAHLMVEFFTKQGKYSDAIAIILSSKNRFNWTYSMVRNLHKALEEIEDRNSVEILLDVVNKKSHAKALKWEEQELNM
What is the function of this protein?
RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts.  Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (By similarity).
What are the official names of this protein?
Mitochondrial group I intron splicing factor CCM1, COB and COX1 mRNA maturation protein 1, Required for respiratory growth protein 2.
What is the protein family that this protein belongs to?
Belongs to the CCM1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: OPGG_SERP5
Sequence: MLVNILSKKPRAASVRWLGATVLFTLLTSPAWAFSIDDVAKQAQDLAGKGFEAPKSNLPSQFREMKFADYQQIQFNHDKAYWSKLKTPFKLEFYHQGMYFDTPVKINEVTSTTVKQIKYSPDYFNFGSVKHDPDSVKNLGFAGFKVIYPINSADKNDEIMSLLGASYFRVVGKGQVYGISARGLAIDTALPSGEEFPRFREFWVERPKQGDKHLVIYALLDSPRATGAYRFVVYPGRDTTVDVESKVFLRDKVGKLGMAPLTSMYLFGPNQPSPTLNYRPALHDSNGLSIHAGNGEWIWRPLNNPKHLSVSTYQVENPKGFGLLQRGRNFKDYEDLDDRYDLRPSAWIEPRGDWGKGKVELVEIPTADETNDNIVAFWTPDVLPDAKTPLALNYRLHFTRDEDKLHSQDIAYVSQTMRSTGDVKQSNLIREPDGSVAFLVDFVGPVLKGLDGATPVAAQVSIGDNGEMVENNVRYNPVTKGWRLTLRLKVKDDKKPVEMRAALVNGDKTLSETWSYQLPANE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: G6PD_ECOLI
Sequence: MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQLNPDTRIIGVGRADWDKAAYTKVVREALETFMKETIDEGLWDTLSARLDFCNLDVNDTAAFSRLGAMLDQKNRITINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSQEINDQVGEYFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDKAGQMRDMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKSSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKESWQDLPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMITRDGRSWNEFE
What is the function of this protein?
Probable source of extracellular death factor (EDF, sequence Asn-Asn-Trp-Asn-Asn, NNWNN) following processing and amidation.  This pentapeptide stimulates cell death mediated by MazF (PubMed:17962566).  Artificial peptides with altered sequence show that NNGNN, GNWNG and NWN no longer stimulate MazF's endoribonuclease activity; other peptides (NNGN, GNWMM, NNWNG, NNNWNNN) retain MazF-stimulating activity.  NNWNN, NNGN, GNWMM and NNWNG prevent cognate antitoxin MazE from inhibiting MazF; although NNNWNNN stimulates MazF it does not do so in the presence of MazE.  EDF also stimulates ChpB's endoribonuclease activity in vitro; in this case NWN partially stimulates ChpB, whereas NNGNN, GNWNN, NNWNG, GNWNG and NNNWNNN do not.  Only the wild-type EDF peptide prevents cognate antitoxin ChpS from inhibiting ChpB (PubMed:21419338).
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
Protein: SMC3_PLAF7
Sequence: MYIKQIRLKGFRTYKNETTIDFTRGINCIVGFNGSGKSNILLAIEFILSDVCEYKQIYLHEGIGNAVRNCYVEIIFDNSEKYFSMFKESEIKIKKVLENMKCEIFVNDKNISKNQYVELLESCGLCINNLYNIIKQGQIIKLSNMKDEEILNYLKSILGAKIFEEKKKDALSMLKECDSKKVTIEKEFNDMNSKLESLQEEFENFLEYKKLEKEKVHLDYFLNEINYKNIYEETQMLKSKLQELKNKTQDEDNHLNLSNNNKSEYNEKLNKMKLEIASCQNHLNKTISEDIQNKRNIVHLQMLIDEKIKEKNIKESQNKNRIKNINQINEFILRVNEKLQSLKSDIVSKEKQIENKNNEINMLLSKNKNKNTDANYSHNVKKIEKMINDINIELSFLEKETIKNEKYLKELEEESKVLNKSIKENETLSQKYGSEINELNNKSEKCVEQKRQCQQKISEGTTNLNEIKCQIIEVNDKYDEIIKSSNKEILKIVDLIMAEKSIKRENILGFLIDNINVDKTYVKAVDTILENHYFTLIVEDMQTAKKIVEFIEKKREERTSKEFNFKEFYFGKLTIVPLLNIKKFNEFNYPNDKNIVPLIKCVNYNSKIYEFLKNILFKTIIVKSLESCENYLEDNYNCVNIDGDYLSKHGFMYGGYNKKKYGIYTVYNKLKELKEEEKKEKSHIEELNNNIEKIDDELRNIYDTKSSTVAKKNGCASTINSINNNIYSNEENIRLTSEKINYIQEKKQNLEQHKDQLKMQILQLRNNNVNPDESEKVGSTDINSLNDEVKKLKEELNKIRNEYDDFKNKLELLYQKRNENDSSIYMEEYEDVDIDEYNNDLADKKDHSDKIEKEKIHYEQKIREINKEMENVKSSIDKILINEKKHKKKILDLCHQMNQINEELRILEGKEENIRKKKVLLPQGIQELEEYRTYDKQQLSAKLKSVTMELKKYSNVNEKAGDRLNILMNDFNELKKRHEEINSSHKNIKDMIQHIGKKKDEALEATYVKINKYFSEYFSLLFKNRKASLVLKKMNEKEYKEKLQEMSEKRIKRRIIDEEVYIDKITGISINITSNDDEKMTYTIQELSGGERSIVAICLFLCLNKIDNFSFFFFDEIDAALDTIHRDNLSLLLKELAHRGTQFIITTFRKELLEYSDNMYIVKIVDRESYISKGTKNEAYEIISIEEKHALEN
What is the function of this protein?
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle.  The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped.  At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.  Cohesion is coupled to DNA replication and is involved in DNA repair.  The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity).
What are the official names of this protein?
Structural maintenance of chromosomes protein 3 homolog.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HDA_ECOLU
Sequence: MNTPAQLSLPLYLPDDETFASFWPGDNSSLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECIAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: TRMD_FLAPJ
Sequence: MRIDIITILPELLRSPFEASIMKRAIDKGLVEVYFHNLRDYTTNKQKSVDDYPFGGGAGMVMNVQPIDDCITHLKSERTYDEVIYMTPDGETLNQKMTNSMSLLGNIIILCGHYKGVDQRVRDHFITREISIGDYVLSGGELGALVLCDALIRLIPGVLSDETSALTDSFQDNLLSGPIYTRPADYKGWKVPEVLTSGHFAKIDKWREDMAYEHTKNRRPDLLDN
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_YERPY
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNVEFFEARRAELEAKLADVLAAAEARATKINELVSVTISSKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTAGEHEVHFQVHSDVFAKLNVVVVPEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RNPA_STRS7
Sequence: MKKSYRVKREKDFQAIFKLGQSMANRKFVIYHLKGEHKHFRAGISVGKKLGNAVTRNAVKRKIRHVLMELGDHLKTEDFVVIARRGAEELDYQAVKQNLHHVLKLAKLLEEGFEIEKKS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RS4_STAA9
Sequence: MARFRGSNWKKSRRLGISLSGTGKELEKRPYAPGQHGPNQRKKLSEYGLQLREKQKLRYLYGMTERQFRNTFDIAGKKFGVHGENFMILLASRLDAVVYSLGLARTRRQARQLVNHGHILVDGKRVDIPSYSVKPGQTISVREKSQKLNIIVESVEINNFVPEYLNFDADSLTGTFVRLPERSELPAEINEQLIVEYYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SURE_YERPE
Sequence: MIRILLSNDDGISAPGIQTLASALRGFAQVQIVAPDRNRSGASNALTLDSALRITTLSNGDIAVQQGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGYPALAVSLNGHQHYDTAAAVTCRLLRALQRKPLRTGKILNINVPDLPLAEIKGIRVTRCGSRHPAEQVFCQQDPRGQDLYWIGPPGEKYDAGPDTDFAAVEQGYVSITPLQVDLTAYMAQEVVESWLANTEVDGEW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_STAAT
Sequence: MSNVTPMMQQYLKIKSEYQDCLLFFRLGDFYEMFYEDAKEASRVLEITLTKRDAKKENPIPMCGVPYHSADSYIDTLVNNGYKVAICEQMEDPKQTKGMVRREVVRIVTPGTVMEQGGVDDKQNNYILSFVMNQPEIALSYCDVSTGELKVTHFNDEATLLNEITTINPNEVVINDNISDNLKRQINMVTETITVRETLSSEIYSVNQTEHKLMYQATQLLLDYIHHTQKRDLSHIEDVVQYAAIDYMKMDFYAKRNLELTESIRLKSKKGTLLWLMDETKTPMGARRLKQWIDRPLISKEQIEARLDIVDEFSAHFIERDTLRTYLNQVYDIERLVGRVSYGNVNARDLIQLKHSISEIPNIKALLNSMNQNTLVQVNQLEPLDDLLDILEQSLVEEPPISVKDGGLFKVGFNTQLDEYLEASKNGKTWLAELQAKERQRTGIKSLKISFNKVFGYFIEITRANLQNFEPSEFGYMRKQTLSNAERFITDELKEKEDIILGAEDKAIELEYQLFVQLREEVKKYTERLQQQAKIISELDCLQSFAEIAQKYNYTRPSFSENKTLELVESRHPVVERVMDYNDYVPNNCRLDNETFIYLITGPNMSGKSTYMRQVAIISIMAQMGAYVPCKEAVLPIFDQIFTRIGAADDLVSGKSTFMVEMLEAQKALTYATEDSLIIFDEIGRGTSTYDGLALAQAMIEYVAETSHAKTLFSTHYHELTTLDQALPSLKNVHVAANEYKGELIFLHKVKDGAVDDSYGIQVAKLADLPEKVISRAQVILSEFEASAGKKSSISNLKMVENEPEINQENLNLSVEETTDTLSQKDFEQASFDLFENDQESEIELQIKNLNLSNMTPIEALVKLSELQNQLK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: CRIPT_RAT
Sequence: MVCEKCEKKLGRVITPDTWKDGARNTTESGGRKLNENKALTSKKARFDPYGKNKFSTCRICKSSVHQPGSHYCQGCAYKKGICAMCGKKVLDTKNYKQTSV
What is the function of this protein?
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).  Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (PubMed:9581762, PubMed:10570482).
What are the official names of this protein?
Cysteine-rich PDZ-binding protein, Cysteine-rich interactor of PDZ three, Cysteine-rich interactor of PDZ3.
What is the protein family that this protein belongs to?
Belongs to the CRIPT family.
What are the subcellular locations of this protein?
Cytoplasm. Synapse. Cell projection, dendritic spine. Note=Colocalizes with DLG4 in asymmetric synapses.
Protein: LIPA_ARTBC
Sequence: MMFLTQLVSALFLFFLGPISYGKPVETFVLPLAQDAPIPPSEDPFYQPPPGYEETEPGTVLRQRRPPFPISLFRSAPIDLAATYQVLYRSSDTFGQPTATVSTILIPHNANMSKVLSYQVVEDAAFINCAPSYALQLHSDPGGLFGTIIIQSELLLITAALENGWVVTIPDYEGPAAAFLAYWRAGYATLDGIRATLASSGFTGVDPDAAVGLWGTSGGSVASAFAADLHPKYAPELNIVGAALGGVVPSITTALHSLNKGFDAGIIVSGVIGLSKEYTYMQPILESYLVPHLRDKFMSAGKKCSGAVSLDFRMEDIFSYFKGGEESGLFADPRVKAILDHNAMPQGVPEIPILILKSVNDEISPISDTDALVEKYCSNGVTIDYKRDLLSVHTILAVTGAPEAVLWLRDRLDGITVEKGCKTSTIFMTLLQPGALEVMSKTIIDNLLNLLGKPVGPRLRTEIVHVPPL
What is the function of this protein?
Hydrolyzes triglycerides, with a preference for substrates with short-chain lengths (C4 to C8).
What are the official names of this protein?
Lipase A.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAA_CLOBK
Sequence: MSTHLTETWEKAINIIKGELTEVSFNTWIKSINPISLENNSLKLAVPNDFTKGILESRYKDLIVNALKLLTSKKYNIDFIVTTEEKIEKNHNNEKSNIVVNDEMSTMLNPKYTFDSFVIGNSNRFAHAASLAVAESPAKAYNPLFIYGGVGLGKTHLMHAIGHYILHNNPKSQVVYVSSEKFTNELINSIKDDKNVEFRNKYRNIDILLVDDIQFIAGKERTQEEFFHTFNALYEANKQIIISSDRPPKEIPTLEDRLRSRFEWGLIADIQAPDFETRMAILKKKADVEKLNIPNEVMVYIATKIKSNIRELEGALIRIVAFSSLTNKEISVDLASEALKDIISSKQTRQVTIDIIQEVVANYYNLKIEDLKSARRTRNIAFPRQIAMYLSRKLTDMSLPKIGEEFGGRDHTTVIHAYEKISNNLKKDESLQNAIKELNKRINQK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_ECOSE
Sequence: MSEQNNTEMTFQIQRIYTKDISFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFLCEVQQGGIFSIAGIEGTQMAHCLGAYCPNILFPYARECITSMVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGTEEHQDA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APC4_MOUSE
Sequence: MLRFPTCFPSFRVVGEKQLPQEIIFLAWSPKRDLIALANTTGEVLLHRLASFHRVWSFPPNESTGKEVTCLAWRPDGKLLAFALADTKKIILCDVEKPESLHSFSVEAPVSCMHWTEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYNSTSKIFSEENSDEIIKLLGDVRLNILVLGGSSGFIELYAYGMFKIARVTGIAGTCIALCLSSDLKSLSVVTEVSSGGESEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKPTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLLYHLSELKGMASWKQKYEPLGLDAAGIEDAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSTHLKESPLLFPYYPRKSLHFVKRRMENVIDQCLQKPADVIGRSMNQAICIPLYKDARSMDCARRLLKFPFLWNNKTSNLHYLLFTILEDSVYKMCILRRHTDISQSVSNGLIGIKFGSFTSASADKVRRSSYSCLDAQFYDDETVTVILKDSMGREGRDRILVQLSLSLVYNSEDSDEYEFTGSYSTRLDEQGSIIPTRTMHFEKHWRLLESMRAQYVAGNGLRKVSCVLSSNLRHVRVFEMDIDDEWEIDESSDDEEEAGGKPVKIKEEVLSESETEAHQDAAALDPDVVIKVEKLDPELDS
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Anaphase-promoting complex subunit 4, APC4, Cyclosome subunit 4.
What is the protein family that this protein belongs to?
Belongs to the APC4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSMD1_HUMAN
Sequence: MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRYQPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 1, 26S proteasome regulatory subunit RPN2, 26S proteasome regulatory subunit S1, 26S proteasome subunit p112.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S1 family.