PharMolix/UniProtQA huggingface dataset:
Protein: PURQ_LACDA
Sequence: MKFAVIQFPGSNCDIDLYEALHTVCGADVAYVPSKESSLDGFDAVMLPGGFSYGDYLRAGAIARFTNIMPAIVEMAKAGKPVFGTCNGFQILTEAGLLPGALKRNDSLKFVCKTVELEVANNDTIFTSEYQKGEKINLPIAHADGSFYADPETLQKIEDNGQVVFRYSKENPNGSLNNIAGITNERGNVLGMMPHPERAVEALLGNTDGLRLFKSILNHAEVKA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_CYTH3
Sequence: MRKKVIAGNWKMNKTLEEGLSLASEVANMAKDEVPADVNLVMCIPYISLAAVSKVINDKVAIGAQNVYQKESGAFTGEISAPMLKSVGVKYVIIGHSERREYFGETNQQLADKVTISLANGLTPLFCCGETLAQREAGIHINFVNAQLTESLFHLSPEDFKKVVIAYEPIWAIGTGVTASDEQAQEMHAKIREHLASKYGAAVADEISILYGGSMKPDNAKGLLACKDIDGGLIGGASLKSRDFIDIAKSY
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPK1B_BOVIN
Sequence: MAKDDSTVRCFQGLLIFGNVIIGMCSIALMAECIFFVSDQNSLYPLLEATNNDDIYAAAWIGMFVGICLFCLSVLGIVGIMKSNRKILLVYFILMFIVYAFEVASCITAATQRDFFTPNLFLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENSDADYPWPRQCCVMNSLKEPLNLDACKLGVPGYYHSQGCYELISGPMNRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIDY
What is the function of this protein?
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells.  May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
What are the official names of this protein?
Uroplakin-1b, UP1b, Uroplakin Ib, UPIb.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL15_PORG3
Sequence: MNLSSLKPAEGAVKSRKRIGRGPGSGLGGTSTRGHKGAKSRSGYSKKIGFEGGQMPIQRRLPKFGFKNINRVEYKPINLSVLQTLSEANSLSKISVEDLIAAGLVSRNSLVKILANGTVTTALTVEAHAFSKTAEEAIVRAGGSVVKL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: DUT_AGRRK
Sequence: MTIHTDTRPTLNLIRLAHGRGLDLPAYETKGAAGMDLRAAIEDGTTLTLAPGKRALVPSGFIFEIPEGFEAQIRPRSGLAFKNGITCLNSPGTVDSDYRGEVKVLLINHGDEPFEITRGMRIAQVVIAPVTQVRVAEITEVSDTARGAGGFGSTGV
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: KCNS1_GORGO
Sequence: MLMLLVRGTHYENLRSKVVLPTPLAGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLHAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHREFEDLLSSVDGVSEASLETSGETSQEGRSADLESQAPSEPPHPQRY
What is the function of this protein?
Potassium channel subunit that does not form functional channels by itself.  Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
What are the official names of this protein?
Potassium voltage-gated channel subfamily S member 1, Delayed-rectifier K(+) channel alpha subunit 1, Voltage-gated potassium channel subunit Kv9.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2.
Protein: TSAD_SHISS
Sequence: MRVLGIETSCDETGIAIYDDEKGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQAALKESGLTAKDIDAVAYTAGPGLVGALLVGATVGRSLAFAWNVPAIPVHHMEGHLLAPMLEDNPPEFPFVALLVSGGHTQLISVTGIGQYELLGESIDDAAGEAFDKTAKLLGLDYPGGPLLSKMAAQGTAGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRDNGTDDQTRADIARAFEDAVVDTLMIKCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMKKRRGEVFYARPEFCTDNGAMIAYAGMVRFKAGATADLGVSVRPRWPLAELPAA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH605_RHIME
Sequence: MAAKEVKFQTDARERMLRGVDVLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQMLREVASRTNDLAGDGTTTATVLAQAIVREGAKAVASGMNPMDLKRGIDLAVDAVVKELKNNARKISKNSEIAQVGTISANGDTEIGRYLAEAMEKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNQDKMRVELEDPYILIHEKKLSNLQAMLPVLEAVVQSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTVVSEDLGIKLESVTLDMLGRAKKVSIEKENTTIIDGAGSKADIEGRTAQIRAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALHATRAAVEEGILPGGGVALLRAVKALDGLKTANNDQRVGVDLVRRAIEAPVRQIAENAGAEGSIIVGKLREKTEFSYGWNAQTNEYGDLYAMGVIDPAKVVRTALQDAASVAGLLVTTEAMIAEKPKKEAAPALPAGGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 5, 60 kDa chaperonin 5, Chaperonin-60 5, Cpn60 5.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WTF1_ARATH
Sequence: MEPKLLLSAHKPLFVSCNSPFNEKTKLSVKSGLPMSTIRAARSQFMGEGLILGNKYGFWSTSRKTRVVVEPVRAAVKRRKELTFDSVVQRDKKLKLVLNIRKILVSQPDRMMSLRGLGKYRRDLGLKKRRRFIALLRKYPGVFEIVEEGAYSLRFKMTSEAERLYLDEMRIRNELEDVLVVKLRKLVMMSIDKRILLEKISHLKTDLGLPLEFRDTICQRYPQYFRVVPTPRGPALELTHWDPELAVSAAELSEDDNRTRESEERNLIIDRPPKFNRVKLPRGLNLSKSETRKISQFRDMQYISPYKDFSHLRSGTLEKEKHACGVIHELLSLTTEKRTLVDHLTHFREEFRFSQQLRGMLIRHPDLFYVSLKGERDSVFLREAYRNSELIDKDPLTLVKEKMRALVSVPRFPRRGGPRKDEEGREVEIDGSDADGEEEEEESDAEEWSDVDGYLEGEDGGNDDDGDWTDDEGEEDVPPNFDDDDEDEEEDSVKIGLSPSSRKSSSPRKKEEKVLTPVFPDGTPREKW
What is the function of this protein?
RNA-binding protein involved in group II intron splicing.  Binds specific group II introns and promotes their splicing.  Functions in the context of a heterodimer with the ribonuclease III domain-containing protein RNC1.
What are the official names of this protein?
Protein WHAT'S THIS FACTOR 1 homolog, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GSTA1_HUMAN
Sequence: MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
What is the function of this protein?
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable).  Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).  It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686).  Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).
What are the official names of this protein?
Glutathione S-transferase A1, 13-hydroperoxyoctadecadienoate peroxidase, Androst-5-ene-3,17-dione isomerase, GST HA subunit 1, GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1559_NITEC
Sequence: MQVIIISGLSGSGKSIALKALEDSGYYCVDNLPASLLVILINHLQTQHHSHVAVAIDMRSGDSITVLPWQFKMIDKSIRTEFIFLDTRTDTLIQRFSETRRRHPLSDKNITLEEAIQHEREVLATVSDLGHHIDTSSLRPNALRAFIRDFISDSRDPSQLTLMFQSFGYKHGIPLDADLVFDIRCLPNPFYDPHLKELTGHDLEVIRFMEAQPNAAKMLGDIGSFLDTWLPVYMQDNRAYLTVAIGCTGGQHRSVYFAEKLALHFRDAARVLVRHRGLAEYNQYYARR
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Neut_1559.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: ARGC_BACAM
Sequence: MKIGFVGATGYGGTELVRILSHHPHAEECILYQTSGEGNVYSEGYPHLTGLADLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAWVTVIDLSGDLRIKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLAIQQAKLIANPGCFPTAVLLGLAPLAKKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQALNEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRPKGQYPQTKEVYGSNFCDIGVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWDEETGLTIITPIYA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPQ_XANCP
Sequence: MTQPSLSVLYSDHLRTLTARADQALQRGGFDHLVIPSGTTHYQLFDDRDYPFAVNPQFKAWVPLTRMPHSWLVYTPGKRPTVIFYQPFDYWHVVPDAPSGWWVEHCDIHIIRTPEAALPLLPARTERCAILGEAASALGACVPNNPAAVLDFLDYQRAFKTPYELAVMRLAQQLAVRGHRAAEAAFRAGQSEFGIHMAYCSAVGQDANELPYGNIIALNEHGAVLHYTELGRQAPQPLRSFLIDAGASAHGYASDITRTYAADAGSEFQALIDAVDAAQLRMGNAVRAGMDYKQLHVDAHLSLMGILHDFGIITVSPEAALATGVSAAFFPHGLGHLIGLQVHDVAGFAASDRGGRIERPDGHPYLRLTRVLEPGMVVTIEPGVYFIDMLLDEVKKNGHAASVNWDRVAQFAPYGGIRIEDEVVCTDGDPENLTRPVFAAP
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: RLMF_ECO55
Sequence: MSAQKPGLHPRNRHHSRYDLATLCQVNPELRQFLTLTPAGEQSVDFANPLAVKALNKALLAHFYAVANWDIPDGFLCPPVPGRADYIHHLADLLAEASGTIPANASILDIGVGANCIYPLIGVHEYGWRFTGSETSSQALSSAQAIISANPGLNRAIRLRRQKESGAIFNGIIHKNEQYDATLCNPPFHDSAAAARAGSERKRRNLGLNKDDALNFGGQQQELWCEGGEVAFIKKMIEESKGFAKQVMWFTSLVSRGENLPPLYRALTDVGAVKVVKKEMAQGQKQSRFIAWTFMNDEQRRRFVNRQR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP18_ARATH
Sequence: MMTSMEGMVEKGVLDDIIRRLLEGKGGKQVQLSESEIRQLCFNARQIFLSQPNLLDLHAPIRICGDIHGQYQDLLRLFEYGGYPPSANYLFLGDYVDRGKQSLETICLLLAYKIRYPSKIYLLRGNHEDAKINRIYGFYDECKRRFNVRLWKVFTDCFNCLPVAALIDEKILCMHGGLSPDLDNLNQIREIQRPIEIPDSGLLCDLLWSDPDQKIEGWADSDRGISCTFGADKVAEFLDKNDLDLICRGHQVVEDGYEFFAKRRLVTIFSAPNYGGEFDNAGALLSVDESLVCSFEIMKPAPASSSHPLKKDFHNRTLGYNLSA
What is the function of this protein?
Serine/threonine-protein phosphatase that possesses phosphatase activity toward para-nitrophenyl phosphate (pNPP) in vitro.
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1 isozyme 8, Type one protein phosphatase 8.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: SYE_VESOH
Sequence: MIKSRFAPSPTGYLHIGGARTAFFAWIWAKKQHGKFVLRIENTDLERSTQASVDAILQGIDWLGLNYDEGPLYQTDRFDRYKQIIQQLLDEKKAYYCECSKKRLQILREELTKQGKKAKYDGCCRNKNLHTGVVRFNNPKEGIVVFNDVVKGKISINNQELDDLIIARSDNTPTYNLTVVVDDHDMKINIIIRGDDHINNTPKQINLYQALGWHLPEFAHLPMILGNDGIRLSKRHGAVSIMAYRDAGFLPEALLNYLSRLGWSYGNQEIFSINKIVQLFELKNINKASASFNQDKLLWFNQETIKSSSVKNLLSNLTWHLQNQEIIIKDTPNIEIVVRYLQDRCKTLVNMAGELKMFYQDFDTFDEKLAKKFFKDKTPLKRLFVELEMLNTWKADNIKQVVKQVCFELNIGFGRVGQPFRLALSGDGNAGSIDIVAELVGKNKALLRLKMAIDF
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERC_PSEPW
Sequence: MERQLEAYCAHLRNERQVSEHTLLAYRRDLEKVIEYCNTQGIAGWGALQIQQLRQLIARQHHQGQSSRSLARLLSAVRGLYRYLNREGLCQHDPASGLSAPKGERRLPKVLDTDRALQLLDGGVDDDFIARRDQAILELFYSSGLRLSELTNLDLEHLDLAAGLVQVLGKGGKARVLPVGRKAREAMQQWLRLRGIGGPRDGAVFISRQGNRLGPRAIQMRVKAAGERELGQHLHPHMLRHSFASHVLESSQDLRAVQEMLGHADISTTQIYTHLDFQHLAAVYDSAHPRAKRSKGTDS
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACE_CHICK
Sequence: MPAALGLLLPWLSLVGALQPGLEPPQSDPTEAGAVFFASEYNSTAEIVLFRSVSASWEYNTNLTTANAALQVEASLEEQNFTELWGKKAKELYGNIWSNFSDPQLKKIIGSIQTLGPSNLPLDKRQQYNTILSDMDKIYSTAKVCLDNGTCWDLEPDISDIMATSRSYKKLLYAWEGWHNAAGNPLRAKYQEFVTLSNEAYQMDGFEDTGSYWRSWYDSTTFEDDLEHLYNQLEPLYLNLHAFVRRKLYDRYGPKYINLKGPIPAHLLGNMWAQQWNNIYDLMVPYPDKPNLDVTNTMVNQGWNATHMFRVSEEFFTSLGLLEMPPEFWEKSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHVQYYLQYKDQPVSFRGGANPGFHEAIGDVLSLSVSTPSHLQKIGLLSSAVEDEESNINYLLKMALEKIAFLPFGYLIDQWRWNVFSGRTPPSRYNYDWWYLRTKYQGICAPVSRNESNFDPGAKYHIPGNTPYIRYFVSFILQFQFHKALCQAANHTGPLHTCDIYMSKEAGAKLREVLKAGSSKSWQEILFNLTGTDKMDAGALLEYFSPVTTWLQEQNNKTNEVLGWPEFDWRPPIPEGYPEGIDKIVDEAQAKEFLSEYNSTAEVVWNAYTEASWEYNTNITDHNKEVMLEKNLAMSKHTIEYGMRARQFDPSDFQDETVTRILNKLSVLERAALPEDELKEYNTLLSDMETTYSVAKVCRENNTCHPLDPDLTDILATSRDYNELLFAWKGWRDASGAKIKDKYKRYVELSNKAAVLNGYTDNGAYWRSLYETPTFEEDLERLYLQLQPLYLNLHAYVRRALYNKYGAEHISLKGPIPAHLLGNMWAQSWSNIFDLVMPFPDATKVDATPAMKQQGWTPKMMFEESDRFFTSLGLIPMPQEFWDKSMIEKPADGREVVCHASAWDFYNRKDFRIKQCTVVNMDDLITVHHEMGHVQYFLQYMDQPISFRDGANPGFHEAIGDVMALSVSTPKHLHSINLLDQVTENEESDINYLMSIALDKIAFLPFGYLMDQWRWKVFDGRIKEDEYNQQWWNLRLKYQGLCPPVPRSEDDFDPGAKFHIPANVPYIRYFVSFVIQFQFHQALCKAAGHTGPLHTCDIYQSKEAGKLLGDAMKLGFSKPWPEAMQLITGQPNMSAEALMSYFEPLMTWLVKKNTENGEVLGWPEYSWTPYAVTEFHAATDTADFLGMSVGTKQATAGAWVLLALALVFLITSIFLGVKLFSSRRKAFKSSSEMELK
What is the function of this protein?
Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity (By similarity).  Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates (By similarity).  Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin (By similarity).  Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response (By similarity).  Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins (By similarity).  Catalyzes degradation of different enkephalin neuropeptides (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Phe and possibly Met-enkephalin-Arg-Gly-Leu) (By similarity).  Also acts as a regulator of hematopoietic stem cell differentiation by mediating degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) (By similarity).
What are the official names of this protein?
Angiotensin-converting enzyme, ACE, Dipeptidyl carboxypeptidase I, Kininase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase M2 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Detected in both cell membrane and cytoplasm in neurons.
Protein: PLSX_DINSH
Sequence: MAAGTSIGTTPGGSTSPETPPEHGLTGTVISVDAMGGDTGPAAVVGGLAIAAEKNPDIAFLLHGDATELTALVAKRRALDGRVAIRGTSDVVTMHDKPSQVMRGGKDTSMWSAIDAVRNGEATVCVSCGNTGALMALSMVRLRKVPGINRPAIACLWPSRAKSGFNVMLDVGADIKADAQDLLQYALMGASYARNGLGNPTPRIGLLNVGTEEHKGRAELKAAHDLIAQAAPDNDFEFVGFVEGGDIPSDKVDVIVTDGFTGNVALKTAEGTAALIRDFLTQAFEKTPWSKIAAMLAYTSLRRLSKRIDPRRVNGGVFLGLNGTVVKSHGSADATGVAAAIKLAFILAQSGFTERLAARVASAGRARASGAATPEEEAVSGSANG
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: DNLJ_STAAS
Sequence: MADLSSRVNELHDLLNQYSYEYYVEDNPSVPDSEYDKLLHELIKIEEEHPEYKTVDSPTVRVGGEAQASFNKVNHDTPMLSLGNAFNEDDLRKFDQRIREQIGNVEYMCELKIDGLAVSLKYVDGYFVQGLTRGDGTTGEDITENLKTIHAIPLKMKEPLNVEVRGEAYMPRRSFLRLNEEKEKNDEQLFANPRNAAAGSLRQLDSKLTAKRKLSVFIYSVNDFTDFNARSQSEALDELDKLGFTTNKNRARVNNIDGVLEYIEKWTSQRESLPYDIDGIVIKVNDLDQQDEMGFTQKSPRWAIAYKFPAEEVVTKLLDIELSIGRTGVVTPTAILEPVKVAGTTVSRASLHNEDLIHDRDIRIGDSVVVKKAGDIIPEVVRSIPERRPEDAVTYHMPTHCPSCGHELVRIEGEVALRCINPKCQAQLVEGLIHFVSRQAMNIDGLGTKIIQQLYQSELIKDVADIFYLTEEDLLPLDRMGQKKVDNLLAAIQQAKDNSLENLLFGLGIRHLGVKASQVLAEKYETIDRLLTVTEAELVEIHDIGDKVAQSVVTYLENEDIRALIQKLKDKHVNMIYKGIKTSDIEGHPEFSGKTIVLTGKLHQMTRNEASKWLASQGAKVTSSVTKNTDVVIAGEDAGSKLTKAQSLGIEIWTEQQFVDKQNELNS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RPIA_STAAM
Sequence: MKDVKALKLMTLNDVLSQINGDMTLGIGTGSTMELLLPQMAQLIKERGYNITGVCTSNKIAFLAKELGIKICEINDVDHIDLAIDGADEVDPSLNIIKGGGGALFREKVIDEMASRFVVVVDETKIVQYLGETFKLPVEVDKFNWYHILRKIESYADIKVERRVNEDVAFITDNGNYILDCKLPKGIDPYKFHEYLIHLTGVFETGYFLDMADQVIVGTQEGVKILEK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: WTR17_ARATH
Sequence: MCYQTSKKKRRSRKRRAQEEKEKMGKGVVSEKVKLVVALITLQFCFAGFHIVSRVALNIGVSKVVYPVYRNLLALLLIGPFAYFFEKKERPPLTISLLAQFFFLALIGITANQGFYLLGLYYATPTFASAMQNSVPAITFIMACALRLEHIDLVRKHGVAKVLGTLVSIGGATVITLYRGFPIFDQGLNMQKEEVVGSDNSHSLTLGWLYLMGHCLSWAGWMVLQAPVLKQYPAKLTLTSFTCFFGLIQFLVIALFVETDLNNWIIVSWEELFTILYAGIIASGLVVYLQTWCIYKSGPVFVAVFQPLQTLLVAAMAFLILGDQLYSGGIVGAVFIMLGLYLVLWGKNEERKLALEESQQDPESLTKHLLEAQHKKSNSESEV
What are the official names of this protein?
WAT1-related protein At3g18200.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SEPF_THEVB
Sequence: MLGKLRDLMGLTPETDIYDEEYPQGTARTLTTEPGVEPLPASPPTPTHDFDTRPSPSVATGSVPTGSTASNVIGMPNAGRWWGAVAEVLVMQPRSFSEMPEVIKALKERKSVVLNLTLMEPEQAQRSVDFVAGATFTIDGHQERIGESIFLFTPSCVQVSTQVGGVRPSATPTPTPPSAWGMDAQQHHSA
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA (By similarity).
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: MZRA_ENTLS
Sequence: MGLQNMTLRRFTLSMSALLLLCALLWLWAALEQQESSLAIRPVTPNTSMPDGFSIWHHLDANGIRFKSITPQDDALVIKFESSEQSAAAKEVLDRSLPHGYVIALQEDDAIAPQWLSRLRDAPHRLG
What is the function of this protein?
Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.
What are the official names of this protein?
Modulator protein MzrA.
What is the protein family that this protein belongs to?
Belongs to the MzrA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.