PharMolix/UniProtQA huggingface dataset:
Protein: GLYA_SALTO
Sequence: MSGNAESTAYRSALEVIGAVEPRVANAIRAELTDQRESLKLIASENYASPATLLAMGNWFSDKYAEGTVGRRFYAGCQNVDTVEALAAEHARELFGAPYAYVQPHSGIDANLVAFWAVLADRIESPALRRAQARHVNDLTEADWFALRRELGNQRMLGMSLDAGGHLTHGFRPNISGKMFDQRSYGTDPETGLIDYDGVAEAAREFKPLILLGGYSAYPRKVNFRILREIADSVGATFMVDMAHFAGLVAGKAFTGDFDPVPHAHIVTSTTHKSLRGPRGGLVLCGPELAEQVDRGCPMVLGGPLPQVMAAKAVALAEARRPDFVDYAGRIVANAQALADGLQRRGAQLVTGGTDNHLALIDVTGYGLTGRQAEHALLDSGIVTNRNAIPQDPNGAWYTSGIRVGTPALTTRGLGTAELDATAELIHTVLSHTAPGTNADGTSSKAKYVLDPAVADRVGKQASDLLTGFPLYPAIDLG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECU_STRPB
Sequence: MVNYPHNLIRQKVSSVQKQTKQNKVDFANRGMSFEAAINATNDYYLSRQIAVIHKKPTPVQIVKVDYPKRSRAKIVEAYFRQASTTDYCGVYKGHYVDFEAKETRQKTAMPMKNFHLHQIEHMACVLHQKGICFVLLHFSTLKETYYLPAQALISFYQIDNGSKSMPIDYIRKNGFKVAFGAFPQVPYLNIIEQNFLGGDYN
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_BACHK
Sequence: MQQLIAEITKGQLKTDLPSFRPGDTLRVHVKVVEGTRERIQLFEGVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPRIAKIEVLRRGKVRRAKLYYLRNLRGKKARIKEIR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RS10_BURA4
Sequence: MQQQKIRIRLKAFDYRLIDQSAAEIVDTAKRTGAIVRGPVPLPTRIQRFDILRSPHVNKTSRDQLEIRTHQRLMDIVDPTDKTVDALMKLDLPAGVDVEIKLQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PUM3_ARATH
Sequence: MMIPELGRRPMHRGNEDSSFGDDYEKEIGVLLGEQQRRQVEADELERELNLYRSGSAPPTVDGSLSAAGGLFSGGGGASFLEFGGVNKGNGFGGDDEEFRKDPAYLSYYYANMKLNPRLPPPLMSREDLRVAQRLKGSNNVLGGVGDRRKVNDSRSLFSMPPGFEAGKPGASASEWDANGLIGLGLGGKQKSFADIFQADMGHPVVQQPSRPASRNTFDENVDSNNNLSPSASQGIGAPSPYCYAAVLGSSLSRNGTPDPQGIARVPSPCLTPIGSGRVSSNDKRNTSNQSPFNGVTSGLNESSDLVNALSGLNLSGTGGLDERGQAEQDVEKVRNYMFGLQDGHNEVNPHGFPNRSDQARGTASCRNSQMRGSQGSAYNSGSGVANPYQHHDSPNYYALNPAVASMMANQLGTNNYSPMYENASATLGYSAMDSRLHGGSFVSSGQNLSESRNIGRVGNRMMEGGTGHPSHLADPMYHQYARFSENADSFDLLNDPSMDRNYGNSYMNMLEIQRAYLGSQKSQYGLPYKSGSPNSHSYYGSPTFGSNMSYPGSPLAHHGMPNSLMSPYSPMRRGEVNMRYPAATRNYTGGVMGSWHMDASLDEGFGSSMLEEFKSNKTRGFELSEIAGHVVEFSSDQYGSRFIQQKLETATTDEKNMVYEEIMPKALALMTDVFGNYVIQKFFEHGLPPQRRELGEKLIDNVLPLSLQMYGCRVIQKAIEVVDLDQKIQMVKELDGHVMRCVRDQNGNHVVQKCIECVPEENIEFIISTFFGHVVTLSTHPYGCRVIQRVLEHCHNPDTQSKVMEEILSTVSMLTQDQYGNYVVQHVLEHGKPDERTVIIKELAGKIVQMSQQKFASNVVEKCLTFGGPEERELLVNEMLGTTDENEPLQAMMKDQFANYVVQKVLETCDDQQRELILTRIKVHLNALKKYTYGKHIVARVEKLVAAGERRMALQSLPQPLVA
What is the function of this protein?
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.  Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
What are the official names of this protein?
Pumilio homolog 3, APUM-3, AtPUM3.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRK1_PHAJA
Sequence: RPPGFSPFR
What is the function of this protein?
Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity).  May target bradykinin receptors (BDKRB).
What are the official names of this protein?
Bradykinin.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: RFA1_CAEBR
Sequence: MTSIKISSDVFNKYHTNGKLRLSTGYVQEALEKQGYPGHDGVVQILKGKEDIGEQMGHGFTYRIRICDGIFQYNTLVSADIDDQIKREAEHLVEGAIIAITNLSTFSQGAGIKTSFLITGYTLLSRYHQTLSAPEVKPRSHSGNPAEHHGYRPNIVVEDVWPEAESITSEFQENMSNPPAAKMPKRESGGEASHNRVPAPEPHRSRAPPPPARRGPSNTERGVIPIAMVTPYVNNFRIHGMVSRKEDIKNIPAKNMKIFNFEITDSNGDTIRCTAFNETAESFHSTITENLSYYLSGGSVRQANKKFNNTGHDYEITLRNDSVVEAGGELLAAPKLNLKRVSLAEIAGHCGEMIDVLVIVEKMDAEATEFTSKAGKTLTKREMELIDESQALVRLTLWGDEAIKANVDDYHGKVIAFKGVIPREFNGGYSLGTGSGTRIIPVPEISGVSELYDWYTTEKPHSELKLISQTSGGMSEAPRTIAGLQEMQFGKDSDKGDYASVKAMITRINPNSALYKGCASEGCQKKVIESDGEYRCEKCNKSMNKFKWLYMMQFELSDETGQVYVTAFGDSAAKVVGKTAQEVGDLKDENLNEYNATFERLQFVPKMWRLRCKMETYNEEVRQKMTVFSVEEVNQDKYIENLKELIEQMKGIEDEGSY
What is the function of this protein?
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress.  It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism.  Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
What are the official names of this protein?
Probable replication factor A 73 kDa subunit, RP-A p73, Replication factor A protein 1, RF-A protein 1.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNM3A_CHICK
Sequence: MVESSDTPKDTAAVPKCPPPCPEASPAEPLPNGDLEADGAQWKGTEEGGASPKSGRPEEDETESLADGETGRALENGRCTPKEGLDAPADEGELAPSDPQKKRGRRKLLEATEKSKEEKEENNFDSLKMEGSRGRLRGGLGWESSLRQRPMQRHTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAVMNVVEETPRAEPQKEEEASPPASQQPTDPASPNVATTPEPVVADAVDKNTSKSADDEPEYEDGRGLGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLLPLSSFSSAFHQATYNKQPMYRKAIYEVLQVASSRAGKIFPACPENDETDTSKVVEIQNKQMIEWALGGFQPSGPKGLEPPEEERNPYKEVYTEMWVEPEAAAYAPPPPAKKPRKSTTEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFIGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGVYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRNVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHEARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
What is the function of this protein?
Required for genome-wide de novo methylation and is essential for development.  DNA methylation is coordinated with methylation of histones.  It modifies DNA in a non-processive manner and also methylates non-CpG sites.  Acts as a transcriptional corepressor for ZNF238.  Can actively repress transcription through the recruitment of HDAC activity.  Also has weak auto-methylation activity on some Cys residue in absence of DNA.
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, Cysteine methyltransferase DNMT3A.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.
Protein: URED_BLOPB
Sequence: MSDELSQNFIDGWLGELRLNFALRGGRSVLTRCKHVGPFYVKKVFYSENDNTPHVYLLHPPGGLVGGDKLVLDVKLESDSRVLLTTPGAAKFYRSNGLYSEQKHIFRLERNTALEWVPQSSIFFPKSKAKIDTTFIIEQGSRVISFDMLCFGNLSLGSSTYPEEVDIHLNICLSDSIGLQERLRINELNCVMKLGGFRISALLFAVPSDEKTLYKVRKLITSVKHFQVGGATLLDEILVVRLLGNDNQYLKKMLHHIWYTIRPFIIGKKAMLPRIWLT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_GEOUR
Sequence: MAGLAMNTELLRRILVGFIREEVRKIGLQKAVLGLSGGIDSALVAYLAAEALGPENVYACTMPYRTSNPESEAHARLVAERLGINYRVIEITPMVDAYFQMVPDADNMRRGNKMARERMTILYDHSAAYSALVLGTSNKTELLLGYGTLFGDMASALNPIGDIYKTQVWQLSEAMGVPREVIEKKPSADLWAGQTDEQELGFTYREVDELLYQMVDLRCNRQELIAQGFSADFIDKIYGKVQNSHFKRRLPVIAKVSTRTIDRDFRYSRDWGK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: LYRA_STAA8
Sequence: MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILVFKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPITHILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYNFLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAIVAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKTGVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESAESVKQAPQSDDLTNDSNEDEIEQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
What are the official names of this protein?
Lysostaphin resistance protein A.
What is the protein family that this protein belongs to?
Belongs to the LyrA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DDL_STRGC
Sequence: MAKKSLILLYGGRSAEREVSVLSAESVMRAINYDLFSVKTYFITKEGDFIKTQEFSSKPAEDVRLMTNDTVDMSRKIKPSDIYEEGAVVFPVLHGPMGEDGSIQGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVALVDGEDLEQKIQEIEEKLSYPVFTKPSNMGSSVGISKSDNQEELRASLDLAFKYDSRVLVEQGVTAREIEVGLLGNADVKSSLPGEVVKDVAFYDYQAKYIDNKITMAIPAQLPEGVVNTMRQNAEIAFRAIGGLGLSRCDFFYTEDGQVFLNELNTMPGFTQWSMYPLLWENMGLAYPDLIEKLVALAEEAFAKREAHLL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_PHOV8
Sequence: MNQYETVFILTPVLSDVQMKEAVEKFKGILTAEGAEIINEENWGLKKLAYPIQKKSTGFYQLIEFKAEPQVIEKLEINFRRDERVIRFLTFKMDKYAAEYAAKRRNVKSTKKED
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RSMH_LACLM
Sequence: MPKTIAFKHDTVLLHETVDMLEVKPNGIYVDATLGGAGHSEYLLSKLTTGHLYSFDQDETAHANAKVRLSEQLAEDKVTLIKSNFRNLKSALAELDITKIDGILYDLGVSSPQFDDSQRGFSYKKEARLDMRMDQSQTLSAYEVVNDYPYEALVRIFFRYGEDKFSKQIARKIEQSRKIKPIETTIELADLIKSALPQKELKKKGHPAKRIFQAIRIEVNDELGAAEESIEQAIDLLKVDGRISVITFHSLEDRLTKSIFKEYSTVNVPKGLPMLPKEMEAKLKLINRKPVLASEEELEFNNRAHSAKLRVAQKQRD
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_LIGS1
Sequence: MRLRNKPWAKPLIEENPDFVVTEPTKLKGKWHTRFQNNNPIFVEIGMGKGRFIVEMAKKNPEKNYIGLELQTVAVGIALKKQLEEKLPNLQLICANGSGLGEYFEKGEIAGIYLNFSDPWPKKRQTKRRLTYKTFLEQYKEVLDSNGHIEFKTDNQGLFEYSLVSMNNFGMKFDGVWLDLHSSPEAEDNVMTEYEEKFSKKGQPIFKLEAHF
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: UNG_SINMW
Sequence: MDSTIRLEESWKAALGPEFRNGYMTELKRFLLDEKQQGRQVFPRGGEYFRALDLTPLDRVRVVILGQDPYHGDGQAHGLCFSVRPGVRTPPSLVNIYKELKEDLGIDPARHGFLESWARQGVLLLNSVLTVERGRAASHQGRGWERFTDAVIRAVNEQAQPVVFMLWGSYAQRKAAFVDRSRHLVLTAPHPSPLSAHSGFFGCRHFSKANAFLTSKGLDPIDWRLPEDPPLAVERPTPPNC
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR_SHEB2
Sequence: MSKVLILKSSILGGYSQSAVLIDHLASHWETQGAAITVRDLGGKDVLPMVDGEIASGLRGGAELSARQQEMLALSDTLVSELKANDTIVIAAPMYNFTIPAQLKNWIDFIARAGVTFTYTETGPKGLVEGKRAVLVTTRGGAHKDGPTDHVVPYLKTVLGFIGITNVEVVYAEALNMGPEAHDKGMSEAKHSIDQLKA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: RBL_ABIHO
Sequence: KASVGFKAGVKDYRLTYYTPEYQTKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEESQFIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAINKAQAETGEIKGHYLNATAGTCEEMMKRAIFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQRNHGMHFRVLAKALRMSGGDHVHAGTVVGKLEGERDVTLGFVDLLRDDFIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVTNRVAVEACVQARNEGRDLAREGNEVIREACK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NCAP_ABLVH
Sequence: MDSDKIVFKVNNQLVSVKPEVIVDQYEYKYPAIKDQKKPSITLGKAPDLNKAYKSILSGMNAAKLDPDDVCSYLAAAMELFEGVCPEDWTSYGILIARKGDKITPATLVDIKRTDIEGNWALTGGQDLTRDPTVAEHASLVGLLLSLYRLSKISGQNTGNYKTNIADRIEQIFETAPFAKIVEHHTLMTTHKMCANWSTIPNFRFLAGTYDMFFSRVEHLYSAIRVGTVVTAYEDCSGLVSFTGFIKQINLTAREAILYFFHKNFEEEIRRMFEPGQETAVPHSYFIHFRSLGLSGKSPYSSNAVGHVFNLIHFVGCYMGQIRSLNATVISTCAPHEMSVLGGYLGEEFFGKGTFERRFFRNEKELQDYEAAESMKTDIALADDATVNSDDEDYFSGETRGPEAVYTRIMMNGGRLKRSHIRRYISVSSNHQSRPNSFAEFLNKTYSSDS
What is the function of this protein?
Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases.  If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA.  Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation.  The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace.  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication.  Protein N binds protein P in the NC through a different interaction, and can be phosphorylated.  Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N.  During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
What are the official names of this protein?
Nucleoprotein, NP, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: TRMB_ECOL5
Sequence: MKNDVISPEFDENGRPLRRIRSFVRRQGRLTKGQEHALENYWPVMGVEFSEDMLDFPALFGREAPVTLEIGFGMGASLVAMAKDRPEQDFLGIEVHSPGVGACLASAHEEGLSNLRVMCHDAVEVLHKMIPDNSLRMVQLFFPDPWHKARHNKRRIIQVPFAELVKSKLQLGGIFHMATDWEPYAEHMLEVMSSIDGYKNLSESNDYVPRPASRPVTKFEQRGHRLGHGVWDLMFERVK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: SYTL4_HUMAN
Sequence: MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYDQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKETQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMAKQKLGL
What is the function of this protein?
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary.  Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).
What are the official names of this protein?
Synaptotagmin-like protein 4, Exophilin-2, Granuphilin.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity).
Protein: RS14_PROMT
Sequence: MAKKSMIARDVKRKKLVERYAAKRKSLIEAFKSAKDPMERLEIHRKIQALPRNCAPNRIRNRCWATGKPRGVYRDFGLCRNQLRSRAHNGELPGVVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: KDPD_CLOAB
Sequence: MDINYERPDPYYLLNKIDKEEKNKNRGKLKIFFGYAAGVGKTYAMLRAAHYMKELGKDIVIGYIEPHARMDTMSLTKGLPQIPVKNIDYKGVILREFDVDKALLRKPEIILVDELAHTNAKSQRNKKRWKDIEELLDAGIDVYTTLNVQHIESLNDIVANITHVSVRETIPDKVFDDADKVELIDIEPDELLKRFTDGKIYRKEQVKRAFNNFFTKNNLYALREIALRRTADRVNFEIEIARLSKGQITVMATSDQILACIGTSPSSARIIRTAARMAESYHSKWIALYVDTGRSLGKADKETLNANFNLVELLGGELVTVHGENVADQIIRYAELRNTTKIVIGKNHKRTGTLLHFYAKDVVDKLMDSNSYIDVYMIPNSSYYRDHKNSILSKISIQHKGSVKDVLKAIIIMAITTDIAELFSYMGFKDVNVIMIFILGVIIVYMATKGQIMGIISSIAAVLVFNYRFTEPKNSFIVYDKSYLVTFPIMMIVAFIIGSLTNKVQKEAQDSNMREKRTQTLYIVSGKLLSAVGTSEVVSIGIKYISRLVNRNVICYLADTSNKLSTPFVYKKDKGAKEEIIMSKDENAAAYWTFLNGKESGCGTSTFYRAKGYYIPIKIKNKVLGVIGVSCPSGPLRPQKKAVVDTVTGQIAIALDREILSKEQEKSKVEIERERLRSNLLRSISHDLRSPLAGIKGAASTILENGELIDEKRKQELINGIYEDTEWLIRLIENLLSMTKFDEGNTKIKKDVELVEEVVSEAVQRSSKYFKNHKIKVSVPEDVIMVSMDGSLIEQVIINLLDNASKFSPKGSTIEIKVYEKKKDVVFEIIDEGQGISEDILPNIFDRFFTNGSKISDSRRGVGLGLAICKSIVEAHGGKIEAVNKGSGGAIFKFNIPKEL
What is the function of this protein?
Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon.  KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals (By similarity).
What are the official names of this protein?
Sensor protein KdpD.
What is the protein family that this protein belongs to?
In the central section; belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLOT1_PANTR
Sequence: MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAESVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
What are the official names of this protein?
Flotillin-1.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family. Flotillin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endosome. Membrane, caveola; Peripheral membrane protein. Melanosome. Membrane raft. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Membrane-associated protein of caveola.
Protein: PSIE_BACC1
Sequence: MKFNIDHYIASVLQWILNIALIILSIVLSIFLINETITFIQYIFSTKEYTSYKLVESIIVYFLYFEFIALIIKYFKSNYHFPLRYFIYIGITALIRLIIVSHEEPMETLLYAGAILILVIALYISNMRDLRKE
What are the official names of this protein?
Protein PsiE homolog.
What is the protein family that this protein belongs to?
Belongs to the PsiE family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL2_METVA
Sequence: MGKRLISQNRGRGTPKYRSPSHKRKGEVKYRSYDEMEKVGKVLGTVIDVLHDPGRSAPVAKVRFANGEERLVLIPEGISVGEQIECGISAEIKPGNVLPLGEIPEGIPVYNIETIPGDGGKLVRAGGCYAHVVAHDIGKTIVKLPSGYAKVLNPACRATIGVVAGGGRKEKPFVKAGKKHHSLSAKAVAWPKVRGVAMNAVDHPYGGGRHQHLGKPSSVSRNTSPGRKVGHIASRRT
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ECFA1_LISW6
Sequence: MAESFVRLEHVFYKYEDAEKYAVKDVSISAEKGEWVALVGHNGSGKSTIAKLLNGLLFPEEGLIKIGHFVLSEKNIWEIRRQVGMVFQNPDNQFVGATVQDDVAFGLENHGVPHDTMVKRVESALNEVGMQSYALHEPARLSGGQKQRVAIAGVLALQPDVIILDEATSMLDPRGRAEVMETIRIMREQEDITVISITHDLDEVLFADRVIVMNNGEIHSEGTPQEIFQQADAMREIGLGVPFIIELQEKLVAGGFETESTVLSEGALLDQLWKLNSNN
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.