PharMolix/UniProtQA huggingface dataset:
Protein: ACEK_SALTI
Sequence: MPRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKSRIHLYDHHVGLVVEQLRCITDGKSTDADFLLRVKEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFFPDHGWEPLLMRILSDLPLCLPWQNKSRDIRYIIAHLTETLGEDALPRCHVQVANELFYRNKAAWLVGKLTTPDGTLPFLLPIHRTDEGELFVDTCLTTTAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLCYLAESDEKFIEAPGIRGMVMLVFTLPGFDRVFKIIKDKFAPQKEMSAAHVRACYQLVKEHDRVGRMADTQEFENFVLDKRQIDPALMALLRQEAPEKITDLGEHIVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPARYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQTRIKEGHVEDVYAYRRRQRFSVRYETDRRPDKAFAPPSGNVRRA
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_MYCLB
Sequence: MSSPEADPIGPEVLQQWRKLTEEVREHQFRYYVRDAPIISDAEFDALLDRLTVLEEQHPELCTPDSPTQLVGGAGFMTDFVATEHLERMFSLDNAFSGDELNAWVTRIRAEIGNDAHYLCELKIDGVALSLVYRDGRLTRATTRGDGRTGEDVTLNARTIEDVPERLTVSDIYPLPEVLEVRGEVFFRVVDFQALNTSLVEEGKNPFANPRNSAAGSLRQKDPAVTAHRKLRMICHGLGHIEGFRPATQHQAYLALRDWGLPVSEHTTLVNDIAGVQGCIAYWAEHRHEVDHEIDGIVVKIDEVTLQRRLGSTSRAPRWAIAYKYLPEEAQTKLLDIRVNVGRTGRVTPFAFMTPVKVAGSTVGQATLHNPSEVKRKGVLIGDTVVIRKAGDVIPEVLGPVVDLRDGSEREFVMPTTCPECGTTLAPEKEGDADIRCPNARSCPGQLRERVFHVASRSALDIQGLGYEAGVALLAAQVITSEGDLFTLTEKALLRTELFRNKAGELSANGKRLLVNVDKAKTAPLWRVLVALSIRHVGPTAARALATEFGSVDAILAASPEQLAAVEGVGTTIAAAVTEWFTVDWHRVIVNKWRAAGVRMVDERDTSVLPTCEGLTIVVTGSLAGFSRDDAKEAIVARGGKVAGSVSKKIAYVVVGDLPGYKYDKAVELGVPILNEDGFRLLLEQGPPVQQVVD
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: OBG_THIDA
Sequence: MKFIDEAKITVLAGKGGDGSASFRREKYIPKGGPDGGDGGRGGSVYAVADRNVNTLVEFRYTRIFKAQKGENGRGAQCYGKAGDDLTIRVPVGTVFSDVNSGEVVADLAEDGETVCLAKGGKGGLGNIHFKSSTNRAPRQHTLGEPGEEWELALELKVLADVGLLGMPNAGKSTFIRAVSAARPKVADYPFTTLAPNLGVVRVDSERSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTRLLLHLVDISPRWEAGDPVHEARAIVEELRKYDQALYEKPRWLVLNKLDMVDEGEREAVVAKFVEDYGWNGPVFAISALDGSGCSALTYAVMDYLGMLAPRHEAEDPAPPAS
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRNL4_ARATH
Sequence: MKVMVLSLGKASPSKSDHELLDPFVSLVEFSVSPPGGFKDHPHRGFESVTYMFQGGIIHQDCNGNKGTIHEGDVQWMTAGRGIIHSEMPEEQVNKGLQLWINLPSSAKMIEPKNIEISSSEIPSADDYGVEVKVIAGESMGVKSPFYTKTPIMFLDFTLDPKAQTHQAVPESWTAFAYIVEGDEGVFSSSDSSTVQAHNVVVFGTGDEVSVWNTSNSRPLRFLLIAGEPIGEPVVQHGPFVMNSQDEIEMTIGDYRNGMNGFEMAKHWRSE
What are the official names of this protein?
Putative pirin-like protein At3g59260.
What is the protein family that this protein belongs to?
Belongs to the pirin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YDHY_CITFR
Sequence: MNKSQQIATITLAAAKKMAQAVEAKALEINVPVVFSVVDHGGNTLLMQRMDDAFVTSCDISLNKAYTACCLRQGTHEITDAVQPGASLYGLQLTNQQRIVIFGGGLPVILNGKVIGAVGVSGGTVEQDRLLAETALDCFSEL
What are the official names of this protein?
Uncharacterized 15.0 kDa protein in dhaT-dhaS intergenic region, ORFY.
What is the protein family that this protein belongs to?
Belongs to the GlcG family.
Protein: YR5A_AGRFC
Sequence: MSCNQDTEILMLALFQTIDLALNLYTWVLIASAIFSWLYAFNVINSRNQFVNAIGSFLVNVTEPALRPIRRILPNLGGIDISPIILLLIIFFIRSFMWNTLYPMTV
What are the official names of this protein?
Uncharacterized protein Atu2659.1.
What is the protein family that this protein belongs to?
Belongs to the YggT family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCSH_BACCN
Sequence: MSIPNHLRYSEEHEWVKTEGNQVVIGITHFAQSELGDIVFVELPEVGATLEANEPFGSVESVKTVSELYAPVSGKVVAVNEELSDQPELVNESPYEGAWMVKVELSDASEVEKLLTAEKYAEMTNQD
What is the function of this protein?
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.
What are the official names of this protein?
Glycine cleavage system H protein, Octanoyl/lipoyl carrier protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: CHI3_ARAHY
Sequence: MTPQGNKPSSHDVITGRWTPSDADRAAGRVSGFGVITNIINGGLDC
What is the function of this protein?
Defense against chitin-containing fungal and bacterial pathogens.
What are the official names of this protein?
Endochitinase 3, CHIT 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
Protein: GLMS_LEIXX
Sequence: MCGIVGYVGTDKSLEVLLGGLKRLEYRGYDSAGIAVIAPDGSLATAKRAGKLDVLTDELQQHPIPDGGTGIGHTRWATHGGPTDCNAHPHLGDDGRLAVIHNGIIENFATLRDELLAEEFTFESETDTEVAAVLLGREYRAAGSLSEAFQRVVSRLEGAFTLLALHQDQPHVVVGARRNSPLVIGLGEGENFLGSDVAAFVEHTQRALAIGQDQIVTITPEQVTVTDFAGAPVEVEPFDVAWDATAAEKGGWPSFMAKEIAEEPDAVANTLRGRAADGAVHIPELDALGDEFFLGIDQITIVACGTAAYAGLVGSYAIEKWARVPVTVELSHEFRYREPVISGGTLIVSISQSGETMDTLMAVKYAREAGAKAISVCNTQGATIPRESDAALYTHAGPEVAVASTKAFVGQIAALYLFGLSLARVRGTLSAAQQRDAVAELFAVPEKIRAVLESKDTIAQLAHWMSDTRSVLFLGRHVGYPIALEGALKLKELAYIHAEGFAAGELKHGPIALIEPGQPVFVVVPSPRWSDELHKKVVSNIQEIRARGARVIAIAEAGDAAVLPFADEVIRIPLAAPLFEPLLSVIPLQIFAMELAVAKGLDVDQPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_WOLSU
Sequence: MDSLINEIKSAQSSAELEELRIKALGKKGILTAQFALLKNLDEEEKKEKAKELNQLKGEFEREWTLKKEIIATEELHKKLLEEKVDMTLFAPSKGVGSAHPVMITMERIVDYFVSLNFAIKSGPLIEDDFHNFEALNLPKYHPARDMQDTFYFKDGMLLRTHTSPVQIRTMEKETPPIRMICPGAVFRRDYDLTHTPMFHQVEGLVVEEEGKVSFANLKYILEDFLRFMFGEVQVRFRTSFFPFTEPSAEVDISCIFCHGEGCRVCSHTGWLEVLGCGLVDENVFKAVGYKNVSGYAFGLGVERFAMLIHAVSDLRAFFESDLRVLEQFR
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX51A_SCOMO
Sequence: MNVLYTKIFFILILTRTSSALKCVQCFTGYGNIVQDCNKTSYSEPKECADPLSNYCFIGTRYENGTEYIQRYCAIFSIKDQCIEKNNIKACIYTCETDGCNSASRLQISSLVTSIISVLYLITFX
What are the official names of this protein?
U-scoloptoxin(05)-Sm1a, U-SLPTX(05)-Sm1a.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-05 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RAG2_RABIT
Sequence: MSLQMITVRNNTALIQPGFSLMNFDGQIFFFGQKGWPKRSCPTGVFHFDIKQNHLKLKPAVFSKDSCYLPPLRYPATCTFQGSSESEKQQYIIHGGKTPNNELSDKIYVMSVVCKNNKKVTFRCTERDLVGDVPEARYGHSLDVVYSRGKSMGVLFGGRSYMPSNQRTTEKWNSVADCLPHVFLVDFEFGCATSYILPELQDGLSFHVSIARNDTVYILGGHSLANNIRPANLYRIRVDLPLGSPAINCTVLPGGISVSSAILTQTNNDEFVIVGGYQLENQKRMVCNIVSLEDNKIEIQEMETPDWTPDIKHSKIWFGSNMGNGSVFLGIPGDNKQIVSEAFYFYMLKCTEDDVHEDQRTFTNSQTSTEDPGDSTPFEDSEEFCFSAEANSFDGDDEFDTYNEDDEDDESETGYWITCCPTCDVDINTWVPFYSTELNKPAMIYCSHGDGHWVHAKCMDLAERTLIHLSEGSNKYYCNEHVEIARALQTPKRTIPLRKPPMKSLHKKGSGKILTPAKKSFLRRLFD
What is the function of this protein?
Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination.  V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments.  DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.  The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps.  The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes.  The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele.  In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1.  It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity).
What are the official names of this protein?
V(D)J recombination-activating protein 2, RAG-2.
What is the protein family that this protein belongs to?
Belongs to the RAG2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LDHA_MOUSE
Sequence: MATLKDQLIVNLLKEEQAPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLKTPKIVSSKDYCVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPHCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPELGTDADKEQWKEVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGINEDVFLSVPCILGQNGISDVVKVTLTPEEEARLKKSADTLWGIQKELQF
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A, LDH muscle subunit, LDH-M.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KYNB_MARMM
Sequence: MAKMWDISQTLRPDLPVWPGDTAFACDEVWSIGPDCPVQVSRLTLSTHSGAHADAPSHYDQAGDDIASTPLELYVGPCRLVTASGNGPHVQPADLDWAAIDGATRVLVRTYAKFPADDWDPDFRALHADTIERLAATGCRLIGVDAASLDPQTSKTMDAHHAVQRHDMRILEGLVFDGVPDGHYELIALPLKIAGADAAPLRAVLRELP
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.
Protein: TPPII_ORYSJ
Sequence: MWHLRGRSSVTAAAAAALHKPVAHLRLLLAVSAWSVPAAASNVAAASTTTRGGPSPSAGVAPRAMPSSSSSPPSAAEGTTAAAGGFRLTEPSFLESLMPKKEIGVDRFLAAHPEYDGRGALIAIFDSGVDPAAAGLQTTSDGKPKILDVIDCTGSGDVDTSKVVKADDDGSIVGASGTHLTINPSWKNPSQEWHVGCKLVYELFTDTLTSRLKKERKKKWDEHNQEAISEALKQLNEFEKKHSKSDDAKQKMAREDLQSRLEYLRKQAEGYDDRGPVIDIVAWHDGDVWRVAVDTQGLEGNKNCGKLADFVPLTNYRLERKFGIFSKLDACSFVANIYDDGNLVSIVTDCSPHATHVAGIAAAFHPDEPLLNGVAPGAQLISCKIGDTRLGSMETGTGLVRALIAAVEHKCDLINMSYGEPTLLPDYGRFIDLASEVVDKHRIIFISSAGNNGPALNTVGAPGGTSSSIIGVGAYVSPAMAAGAHCVVQAPAEGMEYTWSSRGPTADGDLGVSISAPGGAVAPVPTWTLQSRMLMNGTSMSSPSACGGVALLVSAMKAEGIPLSPYTVRKAIENTAASISDVPEEKLTTGHGLLQVDRAFEYAQQAKELPLVSYRISINQVGKPTSKLRGIYLRGSNTCRQTSEWTVQLDPKFHEDASNMEQLVPFEECLQLHSTDSSVIKIPEYIMVTNNGRTFNIVVNPVNISSGLHYYEVYGIDCKAPWRGPIFRVPITVIKPIALSGEPPALTLSNLSFKSGHIERRFINVPIGASWVEVTMRTSAFDTPRRFFLDTVQICPLKRPIKWEAVVTFSSPSLKNFSFPVEGGLTLELSIAQFWSSGIASHEPTCVDFEIVFHGISVDQKIIGLDGSEAPVRVVARSLLASERLVPVATLNKVKTPYRPVESNLCSLPPSRDRLPSGKQIIALTLTYKFKLEDGAEIKPRVPLLNNRIYDNKFESQYYRISDSNKCVYSSGDVYPNYVKLSKGEYTLQLYIRHDNVQLLEKLKQLVLFIERKLEKKDFIQLSFYSEPDGPTVGNGTFKSSILVPGEPEAFYVGPPSREKLPKNVLPGSVLVGSITYGAVSSFSKKDDQNQHAPASYSISYLIPPSKVDNDKEKGVSSGRKSISERLDDEVRDTKIKFLSGFNQETEDDKSSWTALVASLKPEYPKYTPLLAKILECIVQKATSDDKFSHQKEIIAAADEVVDSIDKEDLAKSLSLKPDPEDEEAQKNKKKMEETRDQLADALYQKGLALAEIESLKTDESTEASAKDVFEENYKELIKWVDAKTTKYGSLTVLRERRCGRLGTALKVLNDMIQDDSEQPKKRLYDLKIQLIEEIGWVHVSAYEKQWMHVRFPPSLPPF
What is the function of this protein?
Serine protease that may function in the proteasome pathway.
What are the official names of this protein?
Tripeptidyl-peptidase 2, Tripeptidyl-peptidase II, TPPII.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
Protein: GREA_STRPG
Sequence: MAEKTYPMTLTEKEQLEKELEELKLVRRPEIVERIKIARSYGDLSENSEYDAAKDEQAFVEGQISTLETKIRYAEIIDSDAVAKDEVAIGKTVIVQEVGTTDKDTYHIVGAAGADIFSGKISNESPIAQALIGKKTGDKVRIESPAATYDVEIISVEKTN
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: NDHJ_DRIGR
Sequence: MQGRLSAWLVKHELVHRSLGFDYQGIETLQIKPEDWYSIAVISYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIQYGVDQPEEVCIKVFAPRRNPRIPSVFWIWKSADFQERESYDMLGISYENHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAH
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RL172_HORVU
Sequence: MVKYSRDPSNPTKSAKACGKDLRVHFKNTRETAFALRRMPLGKAKRYLEDVLAHKQAIPFRRYCRGVGRTAQVKNRQPNGQGRWPAKSAQFVLDLLKNAESNAEVKGLDVDNLYISHIQVNQAQKQRRRTYRAHGRINPYMSNPCHIELILSEKEEPVKKEADNVVAPRKAI
What are the official names of this protein?
60S ribosomal protein L17-2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RPOY_STAES
Sequence: MAVFKVFYQHNKDEVIVRENTQTIYVEGQTEEQVRRYLKDRNFNIEFITKLEGAHLEYEKEHSTHFNVENAE
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: LEU1_SALTY
Sequence: MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: ACEK_CROS8
Sequence: MPPRGLELLIAQTILQGFDAQYGRFLEITAGAQHRFEQADWHAVQQAMKSRIHLYDHHVGLVVEQLRCIMEGKATDPDFLLRVKRHYTDLLPDYPRFEIAESFFNSVYCRLYDHRSLTPDRLFIFSSQPERRFRTMPRPLAKNFFPEQGWQPLLTTLLTDLPLRLPWQDLARDVRYIIAHLNETLGPARLAQAHLEMANELFYRNKAAWLVGKLRLPDATLPFLLPVHRSDDGELFVDTCLTGSAGASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLHYLRHADEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDRFAPQKEMSEAHVRACYQLVKEHDRVGRMADTQEFENFVIEKRRISPELMALLQQEVGQKLTDMGDKISISHLYIERRMVPLNIWLEQATGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPRYPEDELSAEPWYSVAPGDVFPEEFRHWLCADPKIGPLFEEMHSDLFSASYWRALQTRIREGYVEDVYAYRRRQRFCVRWKNHNGHPEAAVSAIAPSAVGEG
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZEP2_HUMAN
Sequence: MDTGDTALGQKATSRSGETDKASGRWRQEQSAVIKMSTFGSHEGQRQPQIEPEQIGNTASAQLFGSGKLASPSEVVQQVAEKQYPPHRPSPYSCQHSLSFPQHSLPQGVMHSTKPHQSLEGPPWLFPGPLPSVASEDLFPFPIHGHSGGYPRKKISSLNPAYSQYSQKSIEQAEEAHKKEHKPKKPGKYICPYCSRACAKPSVLKKHIRSHTGERPYPCIPCGFSFKTKSNLYKHRKSHAHAIKAGLVPFTESAVSKLDLEAGFIDVEAEIHSDGEQSTDTDEESSLFAEASDKMSPGPPIPLDIASRGGYHGSLEESLGGPMKVPILIIPKSGIPLPNESSQYIGPDMLPNPSLNTKADDSHTVKQKLALRLSEKKGQDSEPSLNLLSPHSKGSTDSGYFSRSESAEQQISPPNTNAKSYEEIIFGKYCRLSPRNALSVTTTSQERAAMGRKGIMEPLPHVNTRLDVKMFEDPVSQLIPSKGDVDPSQTSMLKSTKFNSESRQPQIIPSSIRNEGKLYPANFQGSNPVLLEAPVDSSPLIRSNSVPTSSATNLTIPPSLRGSHSFDERMTGSDDVFYPGTVGIPPQRMLRRQAAFELPSVQEGHVEVEHHGRMLKGISSSSLKEKKLSPGDRVGYDYDVCRKPYKKWEDSETPKQNYRDISCLSSLKHGGEYFMDPVVPLQGVPSMFGTTCENRKRRKEKSVGDEEDTPMICSSIVSTPVGIMASDYDPKLQMQEGVRSGFAMAGHENLSHGHTERFDPCRPQLQPGSPSLVSEESPSAIDSDKMSDLGGRKPPGNVISVIQHTNSLSRPNSFERSESAELVACTQDKAPSPSETCDSEISEAPVSPEWAPPGDGAESGGKPSPSQQVQQQSYHTQPRLVRQHNIQVPEIRVTEEPDKPEKEKEAQSKEPEKPVEEFQWPQRSETLSQLPAEKLPPKKKRLRLADMEHSSGESSFESTGTGLSRSPSQESNLSHSSSFSMSFEREETSKLSALPKQDEFGKHSEFLTVPAGSYSLSVPGHHHQKEMRRCSSEQMPCPHPAEVPEVRSKSFDYGNLSHAPVSGAAASTVSPSRERKKCFLVRQASFSGSPEISQGEVGMDQSVKQEQLEHLHAGLRSGWHHGPPAVLPPLQQEDPGKQVAGPCPPLSSGPLHLAQPQIMHMDSQESLRNPLIQPTSYMTSKHLPEQPHLFPHQETIPFSPIQNALFQFQYPTVCMVHLPAQQPPWWQAHFPHPFAQHPQKSYGKPSFQTEIHSSYPLEHVAEHTGKKPAEYAHTKEQTYPCYSGASGLHPKNLLPKFPSDQSSKSTETPSEQVLQEDFASANAGSLQSLPGTVVPVRIQTHVPSYGSVMYTSISQILGQNSPAIVICKVDENMTQRTLVTNAAMQGIGFNIAQVLGQHAGLEKYPIWKAPQTLPLGLESSIPLCLPSTSDSVATLGGSKRMLSPASSLELFMETKQQKRVKEEKMYGQIVEELSAVELTNSDIKKDLSRPQKPQLVRQGCASEPKDGLQSGSSSFSSLSPSSSQDYPSVSPSSREPFLPSKEMLSGSRAPLPGQKSSGPSESKESSDELDIDETASDMSMSPQSSSLPAGDGQLEEEGKGHKRPVGMLVRMASAPSGNVADSTLLLTDMADFQQILQFPSLRTTTTVSWCFLNYTKPNYVQQATFKSSVYASWCISSCNPNPSGLNTKTTLALLRSKQKITAEIYTLAAMHRPGTGKLTSSSAWKQFTQMKPDASFLFGSKLERKLVGNILKERGKGDIHGDKDIGSKQTEPIRIKIFEGGYKSNEDYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYVCKLCNFAFKTKGNLTKHMKSKAHMKKCLELGVSMTSVDDTETEEAENLEDLHKAAEKHSMSSISTDHQFSDAEESDGEDGDDNDDDDEDEDDFDDQGDLTPKTRSRSTSPQPPRFSSLPVNVGAVPHGVPSDSSLGHSSLISYLVTLPSIRVTQLMTPSDSCEDTQMTEYQRLFQSKSTDSEPDKDRLDIPSCMDEECMLPSEPSSSPRDFSPSSHHSSPGYDSSPCRDNSPKRYLIPKGDLSPRRHLSPRRDLSPMRHLSPRKEAALRREMSQRDVSPRRHLSPRRPVSPGKDITARRDLSPRRERRYMTTIRAPSPRRALYHNPPLSMGQYLQAEPIVLGPPNLRRGLPQVPYFSLYGDQEGAYEHPGSSLFPEGPNDYVFSHLPLHSQQQVRAPIPMVPVGGIQMVHSMPPALSSLHPSPTLPLPMEGFEEKKGASGESFSKDPYVLSKQHEKRGPHALQSSGPPSTPSSPRLLMKQSTSEDSLNATEREQEENIQTCTKAIASLRIATEEAALLGPDQPARVQEPHQNPLGSAHVSIRHFSRPEPGQPCTSATHPDLHDGEKDNFGTSQTPLAHSTFYSKSCVDDKQLDFHSSKELSSSTEESKDPSSEKSQLH
What is the function of this protein?
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1.  In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes.  It may act in T-cell activation.
What are the official names of this protein?
Transcription factor HIVEP2, Human immunodeficiency virus type I enhancer-binding protein 2, HIV-EP2, MHC-binding protein 2, MBP-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: HYDA_RHIRD
Sequence: MDIIIKNGTIVTADGISPADLGIKDGKIAQIGGTFGPAGRTIDASGRYVFPGGIDVHTHVETVSFNTQSADTFATATVAAACGGTTTIVDFCQQDRGHSLREAVAKWDGMAGGKSAIDYGYHIIVLDPTDSVIEELEVLPDLGITSFKVFMAYRGMNMIDDVTLLRTLDKAAKTGSLVMVHAENGDAADYLRDKFVADGKTAPIYHALSRPPRVEAEATARALALAEIVNAPIYIVHLTCEESFDELMRAKARGVHALAETCTQYLYLTKDDLERPDFEGAKYVFTPPPRTKKDQEILWNALRNGVLETVSSDHCSWLFEGHKDRGRNDFRAIPNGAPGVEERLMMVYQGVNEGRISLTQFVELVATRPAKVFGMFPEKGTVAVGSDADIVLWDPEAEMVIEQSAMHNAMDYSSYEGHKIKGVPKTVLLRGKVIVDEGTYVGAPTDGQFRKRRKYKQ
What is the function of this protein?
Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives.
What are the official names of this protein?
D-hydantoinase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Protein: UVSX_BPT6
Sequence: MSIADLKSRLIKASTS
What is the function of this protein?
Important in genetic recombination, DNA repair, and replication.  Possesses pairing and strand-transfer activity.  Interacts with dda and gene 32 proteins.
What are the official names of this protein?
Recombination and repair protein.
What is the protein family that this protein belongs to?
Belongs to the RecA family.