PharMolix/UniProtQA huggingface dataset:
Protein: PLK2_PONAB
Sequence: MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAAHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSLELKNRMEYALNMLLQRCN
What is the function of this protein?
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition.  Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains.  Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1.  Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome.  Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity.  Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression.  Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively.  Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK2, Polo-like kinase 2, PLK-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, dendrite. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
Protein: PNMT_PIG
Sequence: MSGTGQSHAADAAPDSDPGQAAVALAYQHFEPRAYLRNNYAPPRGDLSSPDGVGPWKLRCLAQTFATGEVSGRALIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELGLWLREEPGAFDWSVYSQHVCLIEGKGESCQEKERQLRARVKRILPIDVHQPQPLGTGSLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRSGGHLLLIGALEESWYLAGEARLAVVPVCEEEVREALARSGYEVRDLRTYVMPAHLRTGVDDVKGIFFAWAQKKVGV
What is the function of this protein?
Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor.  Other substrates include phenylethanolamine, octopamine and normetanephrine (By similarity).
What are the official names of this protein?
Phenylethanolamine N-methyltransferase, PNMTase, Noradrenaline N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
Protein: CAN1_PONAB
Sequence: MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQMVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELAGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTAELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMETSVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
What is the function of this protein?
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.  Proteolytically cleaves CTBP1.  Cleaves and activates caspase-7 (CASP7).
What are the official names of this protein?
Calpain-1 catalytic subunit, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Micromolar-calpain, muCANP.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.
Protein: VU8_HHV6U
Sequence: MDLEAKEISGNIPNENALAELCRLCESADLSQIENFVGRYKNWCLSIIWPRNCWLRFTPRKDVAGYTEKMFEDMDDHYQGFVEKLCLLGTIQIPYRDVPILIGRSKRIFLHDLETDTLHFVCDNFEQFVRYGVLGTNIITCAEPVYRHGLYEGPRFESLENLMNNDVLRSPYTLNVHVKLNRKGVLGIKAMRKHYIAMLREFDELARCASLDDVGRFVSLNVGRDLRLDMPVFKSLTLGTRDSVWTGTCRLANLKEQEDLVEKVVVLGYLNDHDYESKCTRPILCIGKSGKIYYYDWIDNVLVKLGDCLLTFLRVGFARLFADYGYEKIGKISMRFGRMSTLGMSETYQSCMSLSK
What are the official names of this protein?
Protein U8.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae US22 family.
Protein: UL37_HHV6G
Sequence: KLRAQPAANDPGTDKTIKYSKIQSIIQKINSFTHENSLLANCRAVVELIDDLYRKLYSWFLHVLTFEDIQFPGDTFLDRLLKMDYCFTYYPSSNRHLIDLFEKTLDNQTFTNLDKFFDTSGNSPELLYQKTFSLKIFSKNLTAQDNGLYIYPLLKTDLSILDFLGTENILFHRGLIYHILHQKTIPQERENDLNKINQFFATVIQQVIETKSSCLPASLSQLLDTIFHFNRIGLNMETCRTYIEILSNHMATPDTQPIINTFTINLTHIVFTAHVFFICMENFSPTFIFYNRKKLILEQQRAILIIERNDYSTLWKQISDHIDCLFNVSLSESFFKEYTKGGNEDQKQFLYKNLFEKWGNVFFPFTYSVSTSNNSTAHHITTLELRDICKEVYQSDSPDAYESLLPYSTHPSFKTLYVKIYVIPMVSHITNLTFDKLQSDCRLLTLIHACKLLLPSQHLLLHYMAWLYAFSINVDHIDLGTFTVIKSVIFKIADHINVMTHTIYSPETNLLVSILLNAYTNYLQKYVNPWIKQTITANFSLIQTYITFTKQCASILATKCNINLDNLFIYITIGTDKIVTTSFCSFIATCRNLVRQHEEFEKSLQTIQISETTLTGMLRNIITSVSSSKELLTNEALQKFIDTVQRISQHVNETYQSISMNLEKCKTSNDILIESLKKIIYIVDVLSSNAILNTSLASRCLEAANLAVSNNSFTILEIKKDAVAVFKPFITQLFESMKPTTSLHKKLMSTQKLTTDHIPFLDTFDDRYNLVRHVERQLNWYAAHAEAAQQDLITPLKF
What are the official names of this protein?
Capsid assembly protein UL37 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HHV-1 UL37 family.
What are the subcellular locations of this protein?
Virion tegument.
Protein: CGMA_RHIME
Sequence: MARIDSAVSSSQVYADGESSSARYTRTLSGARSALFTLLIAIALVFTVEVIVRWSWPDTVAYFADPMRPAWTTVAVFFLAMLGVDALFGREHKAALLIAPLAVVPAFISQQKQVFLSDPLYPTDFLFGRQIMELMPVLVKDRPWTAVGVVAGLIAAIVVGALLLRFAWQNFPKLTRRERLMRIAFALPLLVAFWNIMDYNQFSWIRDRLRVIPIMWDQTENYRHNGFALAFAINLPMANVNAPAGYMADAIDRIPVKPLPAGTTHRGKPDVIVLMSESFWDPTRLPKVKLTPDPMPTIRELQGGNVFSPEFGGMTANVEFEALTGFSNAFLPYGSIPYQQYIRNPIPSLATFFRGEGYVSRAIHPFQGWFWNRTAVYKAFGFDMFRSEENMPAMQKRGIFASDESLTKEIIRQADEVEDPFFFFAVTLQGHGPYEANRYAKNTIKVEGDLPEADRQVLATYAQGVKEADDSLKMLMDWAKERDRETIIVLFGDHLPPLNTVYSSTGYMKGITAERKGPKDQMKAEHETPLVVWSNKTGPKKNIGTISPAFLSYQILKQAGYEHPYYTGFLGKVYDHYRVLDRYMLIRKNGKDVADWLRQPKVPASLRDYRFLQHDMMFGKRYSTERFFKSHAELYSAGL
What are the official names of this protein?
Putative cyclic beta-1,2-glucan modification protein.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y496_METJA
Sequence: MVRVVYVVNLPYKKLGVECDGKQLILKMKSKDVEDSIKMNFESAALLKILMEQSAVIAEKINKDFKKDKIKVHNIHDVGTVFGVDGRVSVGVLPADENRVASILVGFHKDDKHISVVVKPKKIALLSVIITKIISENLKLD
What are the official names of this protein?
Uncharacterized protein MJ0496.
Protein: MRPA_ALKPO
Sequence: MTVLHWATISPFLLAILIPFLYKYARRIHTGWFVLVLPLVLFIYFIQYLSITSTGGVVEHTIPWVPSLGINFTVFVDGLSLLFALLITGIGTLVILYSIFYLSKKTESLNNFYVYLLMFMGAMLGVVLSDNLIVLYVFWELTSLASSLLISYWFHREKSTYGAQKSMLITVFGGFAMLGGFSLLYVMTGTFSIRGIIENVDLVTSSELFLPAMILVLLGAFTKSAQFPFHIWLPDAMEAPTPVSAYLHSATMVKAGIYLVARLTPVFAGSAEWFWLLTGFGVVTLLWGSTSAVRQKDLKGILAFSTVSQLGLIMTLLGLGSAAIYFGESVDPAFYSFAIMAAIFHLINHATFKGSLFMTAGIIDHETGTRDIRKLGGLMAIMPVTFTVSLIGLASMAGLPPFNGFLSKEMFFTALLRATEMNAFNMETFGIIIVVLAWIASVFTFLYCLIMFFKTFTGKFKPENYDVKVHEAPIGMLISPVILGSLVIVFGFFPNILAYTIIEPAMQAVLPTVLADGELFHVNIYMWHGFNAELFMTMGVVAAGIILFLMMKNWAKAAFYMKERDPLNWFYDSSLSGVITGSQFVTRIQMTGLLRDYFAYMIVFMILLLGYTMFRYDAFAIDTTNVTEIAPYIWVITIVFIVATLSIPFINKRITAVVVVGVIGFLLALLFVVFRAPDLALTQLLIETVTVLLLMLAFYHLPELRKEEFKPRFNVLNLIISIGVGFFITAIALSSLALGNEAGIEPISQFFIENSKELAGGYNMVNVILVDFRGLDTMLEVLVLGIAALGVIALIKLRMTGREDV
What is the function of this protein?
Mnh complex is a Na(+)Li(+)/H(+) antiporter involved in Na(+) and/or Li(+) excretion and Na(+) resistance.  Na(+)/H(+) antiport consumes a transmembrane electrical potential, and is thus inferred to be electrogenic.  Does not transport K(+), Ca(2+) or Mg(2+).
What are the official names of this protein?
Na(+)/H(+) antiporter subunit A, Mrp complex subunit A, Multiple resistance and pH homeostasis protein A.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IDI2_XANP2
Sequence: MDESGAGRRKEDHIDIVLAGGRVASRLDAGFDRVRFVHCALPELDLDAIDLSTRFLGRPLKAPFLISAMTGGPARAESINAHLAEAAQALGIALGVGSQRIAIEDGSAGGLGADLRRRAPDIALFANLGAAQLLAARGLDAARRAVEMIGADVLVIHLNPLQEAIQQGGDRDWRGVFDRIGSLCVSLSAPVVVKEVGFGLSGAVARRLADCGVAALDVAGAGGTNWALVEGERGTGRSRAVATAFADWGIPTAQAVVEVRAACPDLPLIASGGVRHGVDAAKAIRLGADLVGQAAGTLKAAITSTEAVVEHFSQMTDQLRIACFATGAADLDALRRVPLATMD
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_AGRFC
Sequence: MHEKFTFTLKSTSGGARLGEVAMPRGVIRTPAFMPVGTVGTVKAMYLDQVRELGADIILGNTYHLMLRPGPERVARLGGLHELIRWPHPILTDSGGFQVMSLSGLRKLDEKGVTFKSHVDGSLHHMSPERSIEIQGMLDSDIQMQLDECIALPAERKEIERAMEMSLRWAERCRVAFGEQPGKAMFGIVQGGDQPDLRIRSAEGLKELDLKGYAVGGLAVGEPQDVMLGMLDITLPVLPTEKPRYLMGVGTPDDILKSVARGIDMFDCVMPTRSGRHGLAFTRRGRVNIRNARHAEDMRPLDEQSNCPASRDYSRAYLHHLTRSNEALGGMLLSWHNLAYYQELMQGIRTSIEEGRFADFYAETIEMWARGDIDPV
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RL4_GEOTN
Sequence: MPKVALYNQNGQTIGEIELNDAVFGIEPNKHVLFEAVIMQRASMRQGTHKTKNRAEVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGTVFGPVPRSYSYKLPKKVRRLAIKSALSSKVLENDIVVLDQLSLEAPKTKEMVKILNNLAVDRKALIVTDELNENVYLSARNIPGVKVVAANGINVLDVLSHDKLVITKAAVEKVEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: GLND_XANC5
Sequence: MTDTPAERPDPGVAGDADWAAQARPLLVHADMRLCKRFDQGEPIERLVALRARAVDQLMRNAWMRCIPADSGLSLHAVGGYGRGELFPRSDVDVLVLGDTAAQQQHEQALARLFALLWDVGLPISHAVRSPAQCTAAAADQTVLTALIESRALVADGQARAALATAIAPPQVWPPRDFFQAKREELLARHQRFGDTADNLEPDIKDGPGGLRDLQTLGWMALRAFGVKDLEALVGLGHVGFDEAAALRREREELARLRFGLHIVANRPEERLRFDYQKTLAERLGFADDPESLGVEKMMQRFYRSAALIRRISDRLLQRFEEQFDGEATPEPLGGGFSLRRGYLAADAESWPDGDVLQVFALFAQWAAHREVRGLHSLTARALAEVLRDLPAYDIADATARERFMALLRGPRAVETLNRMARLGVLGQWIPAFASVSGRMQFDLFHVYTVDQHTLMVLRNIALFAAGRADERFSIAHEVWPRLRKPELLLLAGLFHDIAKGRGGDHSELGAVDARAFCLAHRLSEGDTELVTWLVEQHLRMSVTAQKQDISDPEVIHRFATLVGTRERLDYLYLLTCADIAGTSPKLWNAWKDRLLADLYFAARRALREGLEHPPPREERLREARESARTLMQAQGHDDVTIDRQFAGMPDENFLRFRPEQLAWQAASLIEVEIGQTLVKARRAVPDNDALEVFVYSPDRDGLFAAIVATLDRKGYGIHRARVLDAPHDAIFDVFEVLPQETYADGDPQRLAATLRQVLAGDLHKVRPARRAVPRQLRHFRFAPRVEFSESAGGRRTRISLVAPDRPGLLADVAHVLRMQHLRVHDARIATFGERAEDQFQITDEHDRPLSESARQALRDALCACLDPV
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: GSA_FRAP2
Sequence: MENKINSQSLFQEALQYIPGGVNSPVRAFKSVGQEFPRFIKSAKGAYLYDVDWNKYIDYIGSWGPMILGHGDDDVLEAIQCQLKNGLSYGAPCKQEIELAKKIVELMPNIEQVRFVNSGTEATMSAIRLARAYTGRNKIIKFEGCYHGHADEFLVAAGSGALSLGQPNSPGVPEDVVKDTLVASFNDIESIQALFEKYKNEIACIIVEPIAGNMNMIFPQDDFLAKLRAVCDENNSLLIFDEVMTGFRVALGGAQSIYDVKPDLTTLGKVIGGGMPVGAFGGRKEIMQEVSPAGPVYQAGTLSGNPIAMAAGIKTLEKVSQDDFFVKLEAKAKQLVDGLNEAARVYDFNFHAKYLGGMFGLFFCNEKVAVNTFTDLGKTNLKMFNKYFAYMLDNGVYLAPSAYEAGFISIAHSDEDIEKTICLTKKFFQDNQS
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_BIFLS
Sequence: MAGQKIRIRLKSYDHEVIDQSAKKIVETVTNAGATVVGPVPLPTEKNVFCVIRSPHMYKDSREHFEMRTHKRLIDIVDPTPKAVDSLMHIDLPADVNIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: SG3A1_HUMAN
Sequence: MKLAALLGLCVALSCSSAAAFLVGSAKPVAQPVAALESAAEAGAGTLANPLGTLNPLKLLLSSLGIPVNHLIEGSQKCVAELGPQAVGAVKALKALLGALTVFG
What is the function of this protein?
Secreted cytokine-like protein.  Inhibits cell growth in vitro.
What are the official names of this protein?
Secretoglobin family 3A member 1, Cytokine HIN-1, High in normal 1, Pneumo secretory protein 2, PnSP-2, Uteroglobin-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the secretoglobin family. UGRP subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DMA2_YEAS7
Sequence: MYTPIPANTPAPTAPTSSMTSNSSSASNANTTSSSGINPRNRASGTPSNERARPASGISSFLNTFGIRQNSQTASSSAAPDQRLFGTTPSNSHMSVAMESIDTAPQQQEPRLHHPIQMPLSAQFHVHRNYQLPISISLTAPTTTDHQQSSAHNFEGNNVGNVQESLNQRQPNGTNNTTTSIISMAPAATTRNIVGGADGSTIVNNSQEMYKNLRHLIYAANQPNGTEILHLDLPATSAEESNNMFNVDEVTLKQRKDKHGLFSIRLTPFIDSSSTTNQGLFFEPIIRKAGPGSQLVIGRYTERVRDAISKIPEQYHPVVFKSKVVSRTHGCFKVDSQGNWYIKDVKSSSGTFLNHQRLSPASSLSKDTPLRDGDILQLGMDFRGGTEEIYRCVRMRIELNRSWKLKANSFNKEALQRLQNLQKLTTGVEEEDCSICLCKIKPCQAIFISPCAHSWHFRCVRRLVMLSYPQFVCPNCRSSCDLEASFESSDEEDESDVESEGDQLVDQLSVLMETSKDVDSHP
What is the function of this protein?
E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugating enzymes.  Involved in nutritional control of the cell cycle.  Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck.
What are the official names of this protein?
E3 ubiquitin-protein ligase DMA2, Checkpoint forkhead associated with RING domains-containing protein 1, Defective in mitotic arrest protein 2, RING-type E3 ubiquitin transferase DMA2.
What is the protein family that this protein belongs to?
Belongs to the DMA1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MT1X_HUMAN
Sequence: MDPNCSCSPVGSCACAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGTSDKCSCCA
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.  May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525).
What are the official names of this protein?
Metallothionein-1X, MT-1X, Metallothionein-IX, MT-IX.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: NRDR_DEHMB
Sequence: MNCPYCSHPDSKVIDSRDVDDGVRRRRECVVCGQRFTTYERFQPAGLFVVKKDQRREEFNKEKLLSGLRRACEKRPLPAGAVDKVAGDIEAELYNMGKAEIPSTLLGDMVMERLKMLDNIAYVRFASVYREFTDITQLKKVVDNLVNGQDEGIHKGQLSLLPEDKAAPKTRYQRR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PUS10_METST
Sequence: MTEKEYNTRQTQNYALCPKCLSRIYRNPKDRDNSIIPLINNTQKCSICNNLLLNEDKIFKLILKKIKMLKIEFDTFLIATQINNQTITKNQKEIYKITNYHGNNDIKHQIRRDISRLIEEKLGKTYDYKNPEVVIMVKIRKKPYKHNPYPEISNVNIFIDSNPIFIEGKYRKLVRGIPQTKWPCTHCKGKGCEACDYTGQQYKDTVEDLISREILPMTNGNTTKFHGSGREDIDVRMLGEGRPFVIEVKHPFKRKIDLKFLRVLVNSHSDGKIEINDLKYVTKERKASIKNSSVESYKIYSAIAEFENGVTSKDIYNIEKLKTIDQRTPIRVEHRRADLIRTREIKNIEVERINSKKLHLIIKCQGGLYIKELISGDNNRTKPSVSSITNNQAECTQLDVLKVHIPE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase Pus10, tRNA pseudouridine 54/55 synthase, Psi54/55 synthase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase Pus10 family.
Protein: HXC8A_TAKRU
Sequence: MSSYFVNPLFSKYKGGESLEPTYYDCRFPQSVARSHTLVYGPGGAAPGFQHPSHHVQDFFHHGTTGISNPGYQQNPCALACHGDATKFYGYEALPRQTLYGTQQDASLAQYPDCKSSSSSNPGEGQGHLNQNSSPSLMFPWMRPHGQNNTVISYIFSPMFLCVRAYVRVCVCMSVFVCVLKCCLSARVSLTYKMKLVREHDGAHRTCTAGCCCSAAHVHTGLDGRRNGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALSLTERQVKIWFQNRRMKWKKENNKTSFRVRGERLKPRKRATRTVKGKRRKRKKRKRKRRPRSDFMVLFMVIWLKGRKKEWPHKQMKSHKESESVNFMTILSFFFCREENRNPTNVAVINRQKKSSTFILT
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-C8a, FrHOXC-8.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YCGR_PSEPK
Sequence: MFNESDAPQPPKVLSTPLEIAANLRQLQESHDPLIITFHDRSHRFQSYVVHVDRESNTLALDEMIPRDGEKFIENGEHFRVEGFHDGVRIAWECDHALKISEVDGHRCYSGPLPQEVTYHQRRNAFRAALKLSQLVDIILDGAHLKGNGAMRGKLLDISATGCKLRFEGNVEDRLQLGQVYERFKAGNPLGLVDTMVELRHLHYEERINTTFAGVRFHNLSGQAQRKIESFVYQLQREARRFDKDDY
What is the function of this protein?
Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner.  Increasing levels of c-di-GMP lead to decreased motility (By similarity).  Binds c-di-GMP with a dissociation constant of 165 nM.  Binds 2 intercalated (c-di-GMP) dimers per subunit.
What are the official names of this protein?
Flagellar brake protein YcgR, Cyclic di-GMP binding protein YcgR.
What is the protein family that this protein belongs to?
Belongs to the YcgR family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: RS3_CYTH3
Sequence: MGQKVNPIGFRLGVVKGWESNWYGGKTFADKLVEDEQIRKYVLARIPKGGISKIVIERTIKRVTLTINTARPGVVIGKGGAEVDKIKEELKKITGKDVQINIFEIKRPEMEALLVGESIAQQLKARISYRRAMKQAIAGTMRVGALGIKIKLSGRLGGAEMARTDQYKEGRIPLHTLRADIDYAVSEALTVYGKIGIKVWIFKGEVYGKRDLSPNVGNAASGASSSSNNDNASPNQGGPRRKRGGEGNRKKSNK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: 13KDA_SCYCA
Sequence: MIFTAXDRSAIEXV
What are the official names of this protein?
13.2 kDa protein.
What are the subcellular locations of this protein?
Microsome. Endoplasmic reticulum.
Protein: YQGF_LIMRJ
Sequence: MRLMGLDVGSKTVGISVSDPLGWTAQAVEIIPIDEENEIFGIDRVAELVKKEQVAGFVIGLPKNMNNTEGPRVEASQHYGKLLQQRFPDIPIDFQDERLTTVEAHRMLVEEADISRAKQKKVIDEVAATFILQSYLDRHGRLVNKLK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM04_PICST
Sequence: MSLRVSMRAFSLSSRVCARSGSKFSFGDLSKVKLRAPIIPTHKNFDVSPDHPLWAFFPEGNNTETALRSGDELDMNSREWTFAELRRKSFEDLHKLWYLTLKERNILAREVRLAESLRYSRTQQHDALDEKLVTVQKRIKQVLLERQVAHERVQTFTQQQQQYLTEFEERYLNASEHEIVSFNEKLVRLQYAFFGIEPQLQDYDLEDINIKFVEGLSFVANLKVKRYLKQNPAQEQEFELPLNGVVEELPFLLRNVTEAIEEVKALRQSGESVKLDKIDVFPFLRSALSNAIEQEELDQ
What are the official names of this protein?
54S ribosomal protein L4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ADH2_CERRO
Sequence: MGLSGKNVIFVGGLGFIGYEACKQLMAKNMASFFVFDVLDKPEDIKALQALNPKTKVYYTKFDITSKQSIKSALADVVSKVKYIDALINGAGILTDLNVELTMNINLIGLINTTLEGLPLMDKNKQGRGGVIVNIASVLGLEPCPPAAAYCASKFGVMGFSRSIGDPYYYNITGVAVVTFCPGLTETPLKNNIGSKYTFEYSKKISEELNNTKTQKPEVCGAHLAQVVESHENGGIYISNQGTLAKVTPTVYWQPTYH
What are the official names of this protein?
Alcohol dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RL17_RUTMC
Sequence: MRHRKSGRQLNRNSSHRKAMFKNMANSLFLHETIRTTLSKAKELRRVVEPLITKAKIDSVANRRNIFSKLRDDAIVAKLFTELAPFYKDRPGGYIRILKAGFRAGDKALMAIVQLVDFETTTDIVAETTDFS
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: Y2479_OLEA2
Sequence: MPSFDVVSKVDLQEVDNVVNNVKKEVDTRYDFRGSNTELSFDKGGASISILASDDMKMRAVQEMLLANCVRRKVDPKFLDFGKVEAASKGMVKRSVAVKDGISKETAQKIVKKIKASKLKVQAAIQDDQVRVTGKKIDDLQDVIQLLRDDDFGVPLQFINMRS
What are the official names of this protein?
UPF0234 protein Dde_2479.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.