PharMolix/UniProtQA huggingface dataset:
Protein: NANT_SHIB3
Sequence: MSTTTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQGEFGLTTVQAASLISAAFISRWFGGLMLGAMGDRYGRRLAMVTSIVLFSAGTLACGFAPGYITMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIANIVMTLAAATALWFCFAGNLQNAAIVAVLGLLCAAIFISFMVQSTGKRWPTGVMLMVVVLFAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPIIGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDGKPFSGAVPFGSAKNDLVKTKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid.
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GSA_SALAI
Sequence: MTDVLPAGPGRYPAAAPASEALFARARALVPGGVNSPVRAFRAVGGTPRFMVRGEGPWLYDADGRRYVDLVCSWGPMILGHAHPAVVEALHSAAALGTSFGAPTPGEVELAAEIVDRTPVEQVRLVSSGTEATMSAIRLARGCTGRARIIKFAGCYHGHSDALLAAAGSGVATFGLPDSPGVTDAAAGDTIVLPYNDIQAVEAAFAAEGPQIAAIITEAAAGNMGVVAPRDDFNQRLAAIAHANGALLIVDEVMTGFRVSRAGWHGLDACPADLWTYGKVMGGGLPAAAFGGRAEIMAQLAPAGPVYQAGTLSGNPLACAAGLTTLRLADDALYRRLDDTAAVVGRLAGDALAAAGVPHRLSYAGNMFSIFFTDADVVDYASARTQQVPAFKAFFHAMLEAGVYLPPSAFESWFVSAAIDDTALEQIAAALPAAAAAAAAGHGG
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBI_CAMJR
Sequence: MSYIKMKDNCRNFSLSKWQDTRKPWLILIIVTIGLTCIAHFLFQEYLFMKPCEQCVYIRFDMLVMAIGGMIALINPANNIIKIFSYSLAFYGIWLGLEHCLTLNHIHEVVHSENPFAGVDGCREIPIYPFNLPLYKWAPSWFLPTGECGMDTPVVPENAYNHLNAFQKFFIGTPPDFENGLYSNGWYLIPSLKFMNMAICCLIAFLCCFVVLFAMFIAYVLDKNKPNAKIFALVIVALVLVLKFIGESKNPNQNIASLNQVVLRYS
What is the function of this protein?
Required for disulfide bond formation in some proteins.  Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity).
What are the official names of this protein?
Putative protein-disulfide oxidoreductase DsbI.
What is the protein family that this protein belongs to?
Belongs to the DsbB family. DsbI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ZIG1_CAEEL
Sequence: MKNLLLITFFVVSTVTALGGRGSKSALVLVAARSSENHPLHATDPITIWCAPDNPQVVIKTAHFIRSSDNEKLEAALNPTKKNATYTFGSPSVKDAGEYKCELDTPHGKISHKVFIYSRPVVHSHEHFTEHEGHEFHLESTGTTVEKGESVTLTCPVTGYPKPVVKWTKDSAPLALSQSVSMEGSTVIVTNANYTDAGTYSCEAVNEYTVNGKTSKMLLVVDKMVDVRSEFQWVYPLAVILITIFLLVVIIVFCEWRNKKSTSKA
What is the function of this protein?
Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.
What are the official names of this protein?
Zwei Ig domain protein zig-1, 2 Ig domain protein zig-1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: LOX1_ARATH
Sequence: MFGELRDLLTGGGNETTTKKVKGTVVLMKKNVLDFNDFNASFLDRLHEFLGNKITLRLVSSDVTDSENGSKGKLGKAAHLEDWITTITSLTAGESAFKVTFDYETDFGYPGAFLIRNSHFSEFLLKSLTLEDVPGHGRVHYICNSWIYPAKHYTTDRVFFSNKTYLPHETPATLLKYREEELVSLRGTGEGELKEWDRVYDYAYYNDLGVPPKNPRPVLGGTQEYPYPRRGRTGRKPTKEDPQTESRLPITSSLDIYVPRDERFGHLKMSDFLAYALKAIAQFIQPALEAVFDDTPKEFDSFEDVLKIYEEGIDLPNQALIDSIVKNIPLEMLKEIFRTDGQKFLKFPVPQVIKEDKTAWRTDEEFAREMLAGLNPVVIQLLKEFPPKSKLDSESYGNQNSTITKSHIEHNLDGLTVEEALEKERLFILDHHDTLMPYLGRVNTTTTKTYASRTLLFLKDDGTLKPLVIELSLPHPNGDKFGAVSEVYTPGEGVYDSLWQLAKAFVGVNDSGNHQLISHWMQTHASIEPFVIATNRQLSVLHPVFKLLEPHFRDTMNINALARQILINGGGIFEITVFPSKYAMEMSSFIYKNHWTFPDQALPAELKKRGMAVEDPEAPHGLRLRIKDYPYAVDGLEVWYAIESWVRDYIFLFYKIEEDIQTDTELQAWWKEVREEGHGDKKSEPWWPKMQTREELVESCTIIIWVASALHAAVNFGQYPVAGYLPNRPTISRQYMPKENTPEFEELEKNPDKVFLKTITAQLQTLLGISLIEILSTHSSDEVYLGQRDSKEWAAEKEALEAFEKFGEKVKEIEKNIDERNDDETLKNRTGLVKMPYTLLFPSSEGGVTGRGIPNSVSI
What is the function of this protein?
9S-lipoxygenase that can use linoleic acid or linolenic acid as substrates.  Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.  Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.  Function as regulators of root development by controlling the emergence of lateral roots (PubMed:17369372, PubMed:18949503).  9S-lypoxygenase-derived oxylipins may play an antagonistic role to ethylene signaling in the control of responses involving oxidative stress, lipid peroxidation and plant defense (PubMed:21481031).  LOX1-derived oxylipins may be involved in stress signaling from roots to shoots in response to cadmium exposure (PubMed:23314084).  9S-lypoxygenase-derived oxylipins are engaged during infection to control the balance between salicylic acid (SA) and jasmonate (JA) signaling to facilitate infection by the fungal pathogen Fusarium graminearum (PubMed:26075826).  9S-lypoxygenase-derived oxylipins activate brassinosteroid signaling to promote cell wall-based defense and limit pathogen infection (PubMed:26417008).  The LOX1-derived compound (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate protects plant tissues against infection by the bacterial pathogen Pseudomonas syringae pv tomato DC3000 (PubMed:22199234).  The LOX1-derived oxylipins are required to trigger stomatal closure in response to both infection by the bacterial pathogen Pseudomonas syringae pv tomato DC3000, and the pathogen-associated molecular pattern (PAMP) flagellin peptide flg22 (PubMed:23526882).  Contributes to the oxidation of free fatty acids during seed aging (PubMed:28371855).
What are the official names of this protein?
Linoleate 9S-lipoxygenase 1, Lipoxygenase 1, AtLOX1.
What is the protein family that this protein belongs to?
Belongs to the lipoxygenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSG2_PEA
Sequence: MMLSLGSDATVLPFHAKNLKFTPKLSTLNGDLAFSKGLGVGRLNCGSVRLNHKQHVRAVGKSFGADENGDGSEDDVVNATIEKSKKVLALQRELIQQIAERKKLVSSIDSDSIPGLEGNGVSYESSEKSLSRDSNPQKGSSSSGSAVETKRWHCFQQLCRSKETETWAVSSVGINQGFDEIEKKNDAVKASSKLHFNEQIKNKLYERPDTKDISSSIRTSSLKFENFEGANEPSSKEVANEAENFESGGEKPPPLAGTNVMNIILVSAECAPWSKTGGLGDVAGSLPKALARRGHRVMIVAPHYGNYAEAHDIGVRKRYKVAGQDMEVTYFHTYIDGVDIVFIDSPIFRNLESNIYGGNRLDILRRMVLFCKAAVEVPWHVPCGGICYGDGNLVFIANDWHTALLPVYLKAYYRDHGLMNYTRSVLVIHNIAHQGRGPVEDFNTVDLSGNYLDLFKMYDPVGGEHFNIFAAGLKTADRIVTVSHGYAWELKTSEGGWGLHNIINESDWKFRGIVNGVDTKDWNPQFDAYLTSDGYTNYNLKTLQTGKRQCKAALQRELGLPVREDVPIISFIGRLDHQKGVDLIAEAIPWMMSHDVQLVMLGTGRADLEQMLKEFEAQHCDKIRSWVGFSVKMAHRITAGSDILLMPSRFEPCGLNQLYAMSYGTVPVVHGVGGLRDTVQPFNPFDESGVGWTFDRAEANKLMAALWNCLLTYKDYKKSWEGIQERGMSQDLSWDNAAQQYEEVLVAAKYQW
What are the official names of this protein?
Granule-bound starch synthase 2, chloroplastic/amyloplastic, Granule-bound starch synthase II, GBSS-II.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, amyloplast. Note=Amyloplast or chloroplast, granule-bound and soluble.
Protein: SUB4_ARTGP
Sequence: MVCLKTLSVFLAAFAVADARAVFKTQSNKNGEMIADNYIVVMKDGVSHDDFKAHVSSVASIHTTNKAKRGTNTAGMKREFDIMNWRGYHGHFDRDTLEEILNDSKVSYVEQDQVVRISGLTTQRSAPSWGLGRVSHRRAGSRDYVFDDSAGRGVTIYGVDTGIDIRHQDFGGRARWGTNTADRDNADRHGHGTHTASTFAGTAFGIAKNANIVAVKVLGSDGSGSTSGIIAGINYCVQDAQQRGILGKAAMNLSLGGGFSQANNDAVTRAQNAGIFVAVAAGNDNRDARAYSPASAPAVCTVASSTIQDSKSSFSNWGSIVDIYAPGSDIIAARPGGGSQSMSGTSMASPHVAGMGAYLIGMGADPRRVCDQLKQLSTPAISNPGSGTTNRLLYNGSGQ
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPCT2_ARATH
Sequence: MADPDLSSPLIHHQSSDQPEVVISIADDDDDESGLNLLPAVVDPRVSRGFEFDHLNPYGFLSESEPPVLGPTTVDPFRNNTPGVSGLYEAIKLVICLPIALIRLVLFAASLAVGYLATKLALAGWKDKENPMPLWRCRIMWITRICTRCILFSFGYQWIRRKGKPARREIAPIVVSNHVSYIEPIFYFYELSPTIVASESHDSLPFVGTIIRAMQVIYVNRFSQTSRKNAVHEIKRKASCDRFPRLLLFPEGTTTNGKVLISFQLGAFIPGYPIQPVVVRYPHVHFDQSWGNISLLTLMFRMFTQFHNFMEVEYLPVIYPSEKQKQNAVRLSQKTSHAIATSLNVVQTSHSFADLMLLNKATELKLENPSNYMVEMARVESLFHVSSLEATRFLDTFVSMIPDSSGRVRLHDFLRGLKLKPCPLSKRIFEFIDVEKVGSITFKQFLFASGHVLTQPLFKQTCELAFSHCDADGDGYITIQELGEALKNTIPNLNKDEIRGMYHLLDDDQDQRISQNDLLSCLRRNPLLIAIFAPDLAPT
What is the function of this protein?
Possesses acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates (PubMed:19445718, PubMed:28408542).  Exhibits strong acylation activity on lysophosphatidylethanolamine (LPE), and lower activity on lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS) (PubMed:19445718).  Exhibits acylation activity on both LPE and LPC (PubMed:28408542).  Has a preference for 18:1-LPE over 16:0-LPE as acceptor (PubMed:19445718).  Palmitoyl-CoA (16:0-CoA) is a better acyl donor than oleoyl-CoA (18:1-CoA) (PubMed:19445718, PubMed:28408542).  Among several different acyl-CoA species the best acyl donor is eicosanoyl-CoA (20:0-CoA) (PubMed:28408542).  Activity is calcium-independent (PubMed:19445718).  Its activity is essential for maintaining adequate levels of phosphatidylethanolamine (PE), LPE and LPC in the cells, which is crucial for plant growth regulation (PubMed:28408542).
What are the official names of this protein?
Lysophospholipid acyltransferase LPEAT2, Lysophosphatidylethanolamine acyltransferase 2, AtLPEAT2.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass membrane protein. Late endosome membrane; Single-pass membrane protein.
Protein: DNAC_ECOLI
Sequence: MKNVGDLMQRLQKMMPAHIKPAFKTGEELLAWQKEQGAIRSAALERENRAMKMQRTFNRSGIRPLHQNCSFENYRVECEGQMNALSKARQYVEEFDGNIASFIFSGKPGTGKNHLAAAICNELLLRGKSVLIITVADIMSAMKDTFRNSGTSEEQLLNDLSNVDLLVIDEIGVQTESKYEKVIINQIVDRRSSSKRPTGMLTNSNMEEMTKLLGERVMDRMRLGNSLWVIFNWDSYRSRVTGKEY
What is the function of this protein?
This protein is required for chromosomal replication.  It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
What are the official names of this protein?
DNA replication protein DnaC.
What is the protein family that this protein belongs to?
Belongs to the DnaC family.
Protein: RL2_BORA1
Sequence: MALVKVKPTSAGRRGMVKVVSPNLHKGAPHAALLEKKIRGSGRNNNGHITIRHRGGGHKQHYRVVDFRRNKDGIPAKVERLEYDPNRTAHIALLCYADGERRYIIAPRGLEVGATLISGIEAPIRAGNTLPIRNIPVGTTIHCIEMIPGKGAQMARSAGASAVLMAREGTYAQVRLRSGEVRRVHIECRATIGEVGNEEHSLRQIGKAGAMRWRGIRPTVRGVAMNPIDHPHGGGEGRTGEAREPVSPWGTPSKGYKTRRNKRTNNMIVQRRKRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SYR_ECO24
Sequence: MNIQALLSEKVRQAMIAAGAPADCEPQVRQSAKVQFGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLNGIASKVEIAGPGFINIFLDPAFLADHVQQALASDRLDVATPEKQTIVVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFLGHKVIRANHVGDWGTQFGMLIAWLEKQQQENAGEMELADLEGFYRDAKKHYDEDEEFAERARNYVVKLQSGDEYFREMWRKLVDITMTQNQITYDRLNVTLTRDDVMGESLYNPMLLGIVADLKAKGLAVESEGATVVFLDEFKNKEGEPMGVIIQKKDGGYLYTTTDIACAKYRYETLHADRVLYYIDSRQHQHLMQAWAIVRKAGYVPESVPLEHHMFGMMLGKDGKPFKTRAGGTVKLADLLDEALERARRLVAEKNPDMPADELEKLANAVGIGAVKYADLSKNRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVLSVFRKAEINEEQLAAAPVIIREDREAQLAARLLQFEETLTVVAREGTPHVMCAYLYDLAGLFSGFYEHCPILSAENEEVRNSRLKLAQLTAKTLKLGLDTLGIETVERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSMD7_BOVIN
Sequence: MLELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRGYLEKVATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEDSKKDRKDDKEKEKEKSDVKKEEKKEKK
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 7, 26S proteasome regulatory subunit RPN8.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family.
Protein: GRPE_BACHK
Sequence: MEERNEQVVEEVKEAQVEEAVTPENSEETVEEKSEAALLQEKVDELQAKLTETEGRTLRLQADFENYKRRVQMDKQAAEKYRAQSLVSDILPALDNFERAMQVEATDEQTKSLLQGMEMVHRQLLEALNKEGVEVIEAVGKQFDPNEHQAIMQVEDSEFESNAVVEEFQKGYKLKDRVIRPSMVKVNQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMP_CNIQU
Sequence: TKDPELKQCKKQQKKQQQYDDDDKK
What are the official names of this protein?
Insulin mimetic protein, Cq-IMP.
Protein: HTPG_RHOPS
Sequence: MTTTDTASETKPFQAEVAELLNLMVHSVYSETDIFLRELISNASDALDKLRYESIATPALMEAGGAPKIQIVPRKAPDTLTVIDNGIGMNRQELIDNLGTIAKSGTKSFLTKLTEAKDGAGLIGQFGVGFYAAFMVADNIVVTSRRAGSGEVWTWSSSGGAGFEIAPASEEAAARVVRGTEIVLHLKPDAAKYLEAYQIERIVSEYSDNIQFPIELVPEEGEPRQINSASALWQRSKSELTEEDYNQAYKQIAGAFDEPAMTLHYRAEGRQSYAVLLFAPATKPFDLFEPERKGRIKLYVRRVFITADADLLPPYLRFLRGVIDSEDLPLNLSREMLQNNPQLAQIRKAVTGKVIGELESLADKKPEDFARIWEAFGPVLKEGLYEDYERREKLLALARFTTTAGEKRTLSQYVEAMKENQTEIYYLVGDSIERLKSNPKLESATARGIEVLLLTDGVDAFWTSGQLDFGGKPLKSLSQGDVNFDLIPKLDADKPDDKPDETKADEATVIAVIKDALGERVSDVKASQRLTSSASCLVAGGFGPDRELEKMLARANKGAATKPVLEINLGHPLVAALADAKADKADATDLSFLLLEQAQILDGELPEDPAAFAGRLNRLVLRGLVAHG
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUTB_ECOUT
Sequence: MPRPSPCADSGGGMMTTLTARPEAITFDPQQTALIVVDMQNAYATPGGYLDLAGFDVSTTRPVIANIQTAVTAARTAGMLIIWFQNGWDEQYVEAGGPGSPNYHKSNALKTMRNQPLLQGKLLAKGSWDYQLVDELVPQPGDIVLPKPRYSGFFNTPLDSILRSRGIRHLVFTGIATNVCVESTLRDGFFLEYFGVVLEDATHQAGPEFAQKAALFNIETFFGWVSDVETFCDALSSTSFARIA
What is the function of this protein?
Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate.  The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.
What are the official names of this protein?
Ureidoacrylate amidohydrolase RutB.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family. RutB subfamily.
Protein: GYRA_STRCO
Sequence: MTTPEGDALAMRVEPVGLETEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYDGGYRPERGFYKCARVVGDVMGNYHPHGDSSIYDALVRLAQPWSMRMPLVDSNGNFGSPGNDPAAAMRYTECKMAPLSMEMVRDIDEETVDFTDNYDGRSQEPTVLPARFPNLLINGSAGIAVGMATNIPPHNLREVAAGAQWYLENYEASHEELLDALIERIKGPDFPTGALVVGRKGIEEAYRTGRGSITMRAVVEVEEIQNRQCLVVTELPYQTNPDNLAQKIADLVKDGKVGGIADVRDETSSRTGQRLVIVLKRDAVAKVVLNNLYKHTDLQSNFGANMLALVDGVPRTLSLDAFIRHWVNHQIEVIVRRTRFRLRKAEERAHILRGLLKALDAIDEVIALIRRSDTVEIARGGLMDLLEIDEIQANAILEMQLRRLAALERQKIVREHDELQAKITEYNEILASPVRQRGIVSEELTALVEKYGDDRKTKLIPYEGDMSIEDLIAEEDIVVTVTRGGYIKRTKTDDYRAQKRGGKGVRGTKLKEDDIVNHFFVSTTHHWLLFFTNKGRVYRAKAYELPDAGRDARGQHVANLLAFQPDETIAQIRAIRDYEAVPYLVLATKAGLVKKTPLKDYDSPRSGGVIAINLREQADGSDDELIGAELVSAEDDLLLISKKAQSIRFTASDDTLRPMGRATSGVKGMSFREGDELLSMNVVRAGTFVFTATDGGYAKRTSVDEYRVQGRGGLGIKAAKIVEDRGSLVGALVVEEHDEILAITLSGGVIRTRVNGVRETGRDTMGVQLINLGKRDAVVGIARNAEAGREAEEVDGDVAVDETAEGAATTGTDEGEAPSAE
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRP54_METS3
Sequence: MLGNLGENLTKTMKKLVGISVIDKKTIEEVVKEIQRALIQSDVNIALVLDLSKKIKKRALEEEPPKGITPREHVITIIYEEMVNLLGGEAPGLDIDVKPYKILFLGLQGSGKTTTIGKLCRYLQKKGFNPAVVCTDTWRPAAYEQLRQLTEEMQVPLYGDPDNKDALDLAQKGLKEFKNRKVIIFDTAGRHKQEEDLIAEMDTLDDIIQPTESILVIDGTIGQQAGEQAKAFSQATDVGSIIITKLDGSAKGGGAMSAVAETGAPIKFIGTGERIDDFELFDPARFISRLLGMGDIQTLIEKAEDSIDEDMAEKTMKNMMSGKFTLVDMKNQFEMMNSMGPMQQVLSMIPGLGNKVSKEASKMTEDKIDGYKVIMSSMTKKEMENPKLIKQSRIRRIAMGAGVEESEVRDLLKYYNNTKKTMKGIGKRGRFGNNSMNRMMGQFMK
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
What are the official names of this protein?
Signal recognition particle 54 kDa protein, SRP54.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: ECFA2_MYCGA
Sequence: MFKSWSKRLKYAPTPLVGDEVLRAQGLKCVFDEKTPEEFWALNGIDFTFEKNKIYCIIGNSGSGKSTLVTHFNGLLTSKYGTLSIRDFKNNHDIVISPNTKKIKNFKRLRKIISMVFQFPEYQLFKDTIQKDIMFGPVALGVHKEEAAKLAKFYLNRMGLDSSYLDVSPFELSGGQKRRVAIAGILAIQSEIIIFDEPTAGLDPKGESEMVELILESKKENKTVIVITHQMEKVLEIADEVILLDKGKILTSGTPYQIFTNPEIMQTTSIALPHVVQVINDLSLRNPIFKKLYDYEPRTVKDLAKVINEVIKNYEKRN
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: KGUA_MYCPN
Sequence: MQSRLAWSKGNWTGLVGSLISLTSSSTSHALVGNNSILICGKIKIILNIEMVDTGRIFVITGPSGVGKSSLVRCLIDHFKDKLRYSISATTRKMRNSETEGVDYFFKDKAEFEKLIAADAFVEWAMYNDNYYGTLKSQAEQIIHNGGNLVLEIEYQGALQVKQKYPNDVVLIFIKPPSMEELLVRLKKRNDEDAITIQNRLKQAEKECQQIGHFKYVVTNNEFDKTLAELQAILLAEFN
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_MOOTA
Sequence: MSEQNVARRYARALFNIAREQGTAGEFANGLEEVSRTLAENSDFRRVLYHQLIPVREKQKLIDTIFPDINPLLKNFLHLVLAKGRERALPEMAAQFRRLVDQAENILPVEVTSAITLREDILAGLKERLAGITRRNIRLSSRVNPELIGGVVIRLGDRVLDASVKKKLELLGEHLKRA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CDK17_RAT
Sequence: MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEESSSKDNEPIVKNGRPPTSHSMHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQISSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGSIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRAPAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGVFVINHFTCRS
What is the function of this protein?
May play a role in terminally differentiated neurons.  Has a Ser/Thr-phosphorylating activity for histone H1.
What are the official names of this protein?
Cyclin-dependent kinase 17, Cell division protein kinase 17, PCTAIRE-motif protein kinase 2, Serine/threonine-protein kinase PCTAIRE-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: CYB_APOSY
Sequence: MTNIRKTHPLLKIINHSFIDLPAPSNISSWWNFGSLLGICLMIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYTFMETWNIGVILLFAVMSTAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVIVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDILGVLMMVSFLMTLVLSFPDLLGDPDNYMPANPLNIPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILALLPFLHTSKQRSLMFRPITQTLYWILVANLLVLTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKMLKWNL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.