PharMolix/UniProtQA huggingface dataset:
Protein: PP1RA_XENLA
Sequence: MGSGPIDPLELLKGLDNILGQGGEVKALEGMAKIFNLMKQSQKMVNRCIYLNIVLQTHSPDILSKFIRVGGYKLLNNWLTYARTCNNSPLLHQILLTLQHLPLTVDHLKQNNTAKLVKQLSKSSEDEELRKLAGILVNDWMAVIRSQTNIQPADKEKKKKKEDAKGSSPVLDKTSEAKSEDNGDKKEKPKIQRTTAPSHAKFRSTGLEVEASSLVPVKKPTPVPVLSDKYLKPVPVKRQSSVPVPGDAAPAEKKYKPLNIVPNTTKEIKVKIIPPQPIESLGFLDALNSAPVPGIKIKKKKKAVSPTSNKASPFDSKSPTEASSLTKPSSPEPEPPVEGMEVERPGTPVPAIELPEPMEISAPPPPAPSETKPSEADASQLTKKGKKRKTVSWPEESRLREYFYFELDETERVNVNKIKDFGEAAKREMLKDRQAFQNARRHSHDTMEEVIPWVLPRLLNLPGALVQMGSNSTEKHAQAEREMGILQEIFLSKESVPDTPHEPDPESYEPSPPKLIPLDEDCSMDDGVYPESMDQSTESQSPDLNGAKLPPVLANLMGSMGSSKSPPNTLPGTMQEILTSIMGAQGNAKPEDLMKQPDFSEKIKHLLGSLQNQNQNQGPPGPAGQGSQGPVNIGFPPPSQKNHQPPPPHHQPPPPHYPPPGPNGPFQGPHGPPGGPRMMGPPPPQRDGYWEPPPNENLRGGSHHGGERGGMRGGDRGPPPPPFHRNRGGRGGEPGYRGRGRGGERGHPGRNGPYGMGHGDHRGHEGHRGHGGHGDHRGHGHGGDMSTRPTCRHFMMKGNCRYENNCAFYHPGINGPPLP
What is the function of this protein?
Probable inhibitor of phosphatase activity.
What are the official names of this protein?
Serine/threonine-protein phosphatase 1 regulatory subunit 10.
What are the subcellular locations of this protein?
Nucleus.
Protein: FKBP5_DICDI
Sequence: MNFSEEEEYSNRNAASSQKLGSLFKDNNAMSGNQSLQYTNNKTQSSANSNSPDVLISFPIHLYKFDNNKNEYVSSGSIATAIVGYKSSGKYQLLAYDNNKNYIVTVNITAQFNYSVTTIYGSFTDGNGQNWSMTFNSAEESTKYATHVAIAKCASGGYQQITFVDINNQSKTKPVANGDRVSIKYAGWLENNQRVGSLFDSNLQSETPFRFVVGEGKVIKGWDLGVIGMRKSAKRILVIPSELAYGKKGHSTIPPNTNLIFDLEVTGSKKKEGSEPSLPSLNGQPSNAPQQSLPTQLFDNSPVPQDDKANLLQRVAKLGRATGFTSPPPSDSENESNSRNSHSNNSHNNNNNNNSNSNNNSNSNSNNNNNNNNQNNNNNNNNQNNNQNNNNNNNYNNNNNNNNGYNNNNNNNGYNNNNNYNNNMNNNNGFNNGMNNGFGNNSMNGMNNGFNNGMNGMNNGMNGGFGMNGNMYTSSQSPQFNPMGTFGSAYNQQQALIGSGALVPIMPQHQQPSIIVASPPPPVQQAPPPTPAPAPPPPTPVIVQAPPAPVQSTTETIQILVEEKQFKKEIKHSIDQFNSKLDQVSSKFDSLAQPIVKGDVPISGVLLVQTLHRLVEDNEKLIKENVEKENRMVTLKENIATLHKKNEQFLEENTKMMESRNEAITDNVAQMRRQIIDLQKQKTLVEDDLADKQMLHTKSQSVINQLKRDYNTLQEELNSAKEENQKSIQDQEALKQAEKDYALKIRAFKKSLLDEKNARKSDIEKINSLEDELKDAQDSLTQAEKSNEESLKRLKLDMVRIKKRNDDKVSQLTLEITTLKDTLETERSALSSVQTLVENTRLETESKFNLLLIKKEEAIAAAELSLSEEQSKYNKLVQSNNQQIDQLQKLIDDAKKKLDHEKEEVIKSYKKGFAEGIESTKQENDLITTLQQQIQQLTTQYDDTKKSLIETKEKLSTLESQPPKTIVKEVIVKVPSDGTTVAVASSNNVDVAKEVKVCMQKVFVQVSESFDEDEEYSTDSIMSTFKDVIKRVTVEYIQEQKEKQQQQQEKEEEEVVEEEEKEEEEKEEEEKEEEEKEEEKEEEKEQEEEEEEKEVVVEEIVTIAEEVKEEEVVVEEPVTVVEEVKEEKPTPAIEEPVVAKSQTVVDPLSTKDDEDDDDDEDDYDDINEEDLKNIDAEIEKMQQEMGDELEDDDDEEEEKEKETAPVVTKSEVVDPLSSTKEESEEEEEEETKVEVPVLEEEKEEEETKVEVPVLEDEQEDKVESDVEEKIVEPPTLDEDDFEKVEVPVLGDDEQDEKVVEEPAPEEEEETKVEVPVLNKDDDEDNEKDVASDSEETPSTPPPIDDVEEEEEKEEKVVEQVKEEINETKFESSPFAVDEPTTTEEKEEEKEEEKVEEEEEKVVEPPTIDDDETTAPVIPSIDNSPRQTTTEEEESSTTAATTSTTTTSSTPVKPDEADTTKKTPKKTSFFDFDDSPFSAETETETKSTAASSDPFADTTSSTPTSTKKKDFFSTDDDSLFGNSSDIFDKPSTTTKKDPFDTDSTDDLFGSIKTNKESTSTASSTSNGGLFDSDSLFGGISVAKSNNNTPSRQKQDFSSLFGSDPTISPLTETEPEEKEIVLPL
What is the function of this protein?
PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
FK506-binding protein 5, Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
Protein: RAD1_YEAST
Sequence: MSQLFYQGDSDDELQEELTRQTTQASQSSKIKNEDEPDDSNHLNEVENEDSKVLDDDAVLYPLIPNEPDDIETSKPNINDIRPVDIQLTLPLPFQQKVVENSLITEDALIIMGKGLGLLDIVANLLHVLATPTSINGQLKRALVLVLNAKPIDNVRIKEALEELSWFSNTGKDDDDTAVESDDELFERPFNVVTADSLSIEKRRKLYISGGILSITSRILIVDLLSGIVHPNRVTGMLVLNADSLRHNSNESFILEIYRSKNTWGFIKAFSEAPETFVMEFSPLRTKMKELRLKNVLLWPRFRVEVSSCLNATNKTSHNKVIEVKVSLTNSMSQIQFGLMECLKKCIAELSRKNPELALDWWNMENVLDINFIRSIDSVMVPNWHRISYESKQLVKDIRFLRHLLKMLVTSDAVDFFGEIQLSLDANKPSVSRKYSESPWLLVDEAQLVISYAKKRIFYKNEYTLEENPKWEQLIHILHDISHERMTNHLQGPTLVACSDNLTCLELAKVLNASNKKRGVRQVLLNKLKWYRKQREETKKLVKEVQSQDTFPENATLNVSSTFSKEQVTTKRRRTRGASQVAAVEKLRNAGTNVDMEVVFEDHKLSEEIKKGSGDDLDDGQEENAANDSKIFEIQEQENEILIDDGDAEFDNGELEYVGDLPQHITTHFNKDLWAEHCNEYEYVDRQDEILISTFKSLNDNCSLQEMMPSYIIMFEPDISFIRQIEVYKAIVKDLQPKVYFMYYGESIEEQSHLTAIKREKDAFTKLIRENANLSHHFETNEDLSHYKNLAERKLKLSKLRKSNTRNAGGQQGFHNLTQDVVIVDTREFNASLPGLLYRYGIRVIPCMLTVGDYVITPDICLERKSISDLIGSLQNNRLANQCKKMLKYYAYPTLLIEFDEGQSFSLEPFSERRNYKNKDISTVHPISSKLSQDEIQLKLAKLVLRFPTLKIIWSSSPLQTVNIILELKLGREQPDPSNAVILGTNKVRSDFNSTAKGLKDGDNESKFKRLLNVPGVSKIDYFNLRKKIKSFNKLQKLSWNEINELINDEDLTDRIYYFLRTEKEEQEQESTDENLESPGKTTDDNALHDHHNDVPEAPV
What is the function of this protein?
Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.  Along with RAD10 forms an endonuclease that specifically degrades single-stranded DNA.
What are the official names of this protein?
DNA repair protein RAD1.
What is the protein family that this protein belongs to?
Belongs to the XPF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DEOC_CAEEL
Sequence: MATIVPTLFSFVRDTYKGRFDVATFEREVGRDFDNQEIAQAISKYEQEAKNLRNKDEIRKVIQYIDLTTLNGDDTASKVVALAKRAINPVPTDPSIHCGSVCVYPQRIADVKKFLASSKLNSNITSVAGGFPSGQYHLKSKVLEVELSVADGATEIDIVISRASALDEDWKTVHDEVLACKKACGSAHLKTILATGELKTLSNVYRASWASILAGSDFIKTSTGKESVNATLEVAYVMCTAIKRWHELTGKKVGFKPAGGIKTVDEALSYVALVKDILGDEWLNPHLFRIGASSLLDDCLKGL
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Putative deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
Protein: MURB_STRGC
Sequence: MVNIELLKSELAGIDIRFDEPLKRYTYTKVGGPADYLAFPRNRYELVRLVKFANREQIPWMVLGNASNIIVRDGGIRGFVIMFDQLHTIMVNGYTIEAEAGAKLIDTTHVALHHSLTGFEFACGIPGSVGGAVFMNAGAYGGEIAHVLVSCKVLTPEGEIKTISAEEMKFGYRSSVIQETGDIVISAKFALSPGNYTAIQQEMKRLTHLRELKQPLEYPSCGSVFKRPLGHFAGQLISEAGLKGHRIGGVEVSTKHAGFMVNIADGNAQNYEDLIAHVIQTVEKESGIKLEREVRIIGETLQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_ECOL5
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CC186_PONAB
Sequence: VGLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVNASRDKLVAQDVTAKNAIQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIEVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKIVDQLQEQLQRGKQEIENLKEEVESLNSLISDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKLSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELTCRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVENGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT
What are the official names of this protein?
Coiled-coil domain-containing protein 186.
Protein: IF6_METST
Sequence: MIQKFDIDGNPNLGVSILAKDNVAIVSPGLQDSYLKSIKETLNVPIIKTPICGSNLAGALMAGNSNGLLISPYVFSHELDVLREHDINVEIMPDKLTAIGNIIVANDNGALVNPSLSDEAKRIIKNTLEVEVVETSIAGLDIVGSLVAATNRGALVHPDASEEELDLVEDVLGVPAEIGTVNRGVKLVGACIIANSNGVIVGNKTTGPELARIDQVFNLFEGSL
What is the function of this protein?
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
What are the official names of this protein?
Translation initiation factor 6, aIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
Protein: RF3_SALSV
Sequence: MTLSPYLQEVAKRRTFAIISHPDAGKTTITEKVLLFGQAIQTAGTVKGRGSSQHAKSDWMEMEKQRGISITTSVMQFPYHDCLVNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDAAKGVEDRTRKLMEVTRLRDTPILTFMNKLDRDIRDPMELLDEVENELKIGCAPITWPIGCGKLFKGVYHLYKDETYLYQTGKGHTIQEVRIVKGLNNPDLDAAVGEDLAQQLRDELELVQGASNEFDEELFLAGEITPVFFGTALGNFGVDHMLDGLVAWAPAPMPRQTDTRTVEASEEKFTGFVFKIQANMDPKHRDRVAFMRVVSGKYEKGMKLRQVRTGKDVVISDALTFMAGDRSHVEEAYPGDILGLHNHGTIQIGDTFTQGEMMKFTGIPNFAPELFRRIRLKDPLKQKQLLKGLVQLSEEGAVQVFRPISNNDLIVGAVGVLQFDVVVARLKSEYNVEAIYESVNVATARWVESADAKKFEEFKRKNETQLALDGGDNLTYIAPTMVNLNLTQERYPDVQFRKTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHMP7_XENLA
Sequence: MAPLSCNPPEWEDDERMSFLFSAFKRTRDVNTCDWDGKMKFWIPLILTHARAQGLLSITLSQLENDFRRKGCAPMGLRTVIQEMIRQGTLRKETDFVSGVSSGWLSWGMRQLVIRPLRWTIGTMLGSQVGPDEPLVIPEVIKERAALVLQRYQSSTFRSFPLLCEEEVHTLCAEICPNPSALNLVLLQLQGDKKICVLERAGQKLVKFVRVSVGQVEPISESDLGIYQLQQGEKLLSERLQSAGEESNRLTEEARTYNRAGNKNQALRCLRKRKLVERRITELQNKQDNIQGILERISAAETDRKVVSAYQMGVSALKQALKDVTLEKAESIVDQIQEYCDLQDDLSQTLSSVTDADVDSDDLERELNEILQNEEMIIDLPDVPSGPVIISPKRPTEWKMDQAAHSPADGSFLRSVPEPMLQ
What is the function of this protein?
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase.  Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase.  Plays a role in the endosomal sorting pathway.
What are the official names of this protein?
Charged multivesicular body protein 7, Chromatin-modifying protein 7.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area. Localizes to the nucleus envelope during late anaphase.
Protein: MSHA_SACEN
Sequence: MTATTDLSRTWPRRAAVLSLHTSPLEQPGTGDAGGMNVYIAKTSAKLAELGTEVEIFTRATSSDIPPVAQLAPGVTVRSLLAGPFEGLDKNDLPSQICAFAAGALRVEARHDPGYYDVVHSHYWLSGQVGWLARQRWGVPLVHTAHTLAKVKNAALAEGDTPEPMVRVMGEEQVVAGADRLVANTEFEAADLIERYDADPEAVATIPPGVDLERFTPGDRSAARAEFGLPADAVVLGFVGRIQPLKAPDVLLKATAALLDRHPGLRERLVVLVVGGPSGSGLERPRALHELARSLGITDVVRFLPPQRGDALASVYRACDVVAVPSYSESFGLVALEAQACGTPVVAAAVGGLPVAVADGVSGLLVDGHETRRWADALASVVLSPGRRARLAAGTTGHAAGFSWESTTEALLDTYARARTTFDARLRIREVTA
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: RF2_LEUCK
Sequence: MEIIDAKHALADIQENIARFQGTLDLEALTEEIADFENRMTEPGFWDDNTKAQKVIEENNVLKNRRDSFLNLTNQAEEIEVLIDMLAEDPGDVDTATELADSIAQAQKDVEAYNLEQLLTEPYDANNAILEVHPGSGGTESTDWGANLYRMYTRWAQQHGFQVDVLDYHAGDEAGIDSATIKITGHNAFGFLRSEKGVHRFVRISPFDSAGRRHTSFVSVDVMPELDDTIEVEVRDDDIKMDVFRSGGAGGQNVNKVSTGVRLTHEPTGIVVSSTVERTQYGNRDYAMKLLKSKLYQLELEKQEAERAALTGEKMENGWGSQIRSYVLHPYQMVKDHRTNYETNQPQQVLDGDLDPFINAYLQWQLSLKNPN
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THOP1_MOUSE
Sequence: MKPPAACAGDVVDAASPASTVNHLRWDLSAQQIRALTTQLIEQTKCVYDRVGAQNFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPCKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQEKTPKNSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLSSLEKAEDGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSSLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQLAVAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGSEAPQDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASAMLKQFLGRDPKQDAFLLSKGLQVEGSEAPAC
What is the function of this protein?
Involved in the metabolism of neuropeptides under 20 amino acid residues long (PubMed:10969067).  Involved in cytoplasmic peptide degradation.  Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity).  Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
What are the official names of this protein?
Thimet oligopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DMR16_CRYX8
Sequence: MAPQTKRAAETPKLGVQKAAVIAAAFLSAITAGAMANISMISVPVFMDTNTNPNHMIAQWSRTYHYGHIILPGICVGTCGLYAFSALRSNKNWRRYALAGITTLSLVPFTWVFMTPTNNTLFALEAAGNVSDLGYVQQLVVKWTWLHATRSMFPLIGAILGFTGIMADLER
What is the function of this protein?
Anthrone oxygenase; part of the gene cluster that mediates the biosynthesis of the dimeric xanthones cryptosporioptides (PubMed:30996871).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase dmx-nrPKS (Probable).  The atrochrysone carboxyl ACP thioesterase dmxR1 then breaks the thioester bond and releases the atrochrysone carboxylic acid from dmx-nrPKS (Probable).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase dmxR15, and oxidized by the anthrone oxygenase dmxR16 to yield emodin (Probable).  Emodin is then reduced to emodin hydroquinone by the oxidoreductase dmxR7 (Probable).  A-ring reduction by the short chain dehydrogenase dmxR18, dehydration by the scytalone dehydratase-like protein dmxR17 and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:30996871).  Baeyer-Villiger oxidation by the Baeyer-Villiger monooxygenase (BVMO) dmxR6 then yields monodictylactone in equilibrium with monodictyphenone (PubMed:30996871).  In the case of the cryptosporioptides biosynthesis, monodictylactone is reduced at C-12 to an alcohol (by the short chain dehydrogenases dmxR12 or dmxR8) and hydroxylated at C-5 by dmxR9, yielding the electron-rich aromatic which could eliminate H(2)O to form the ortho-quinonemethide, followed by tautomerisation to paraquinone and complete the formal reduction to produce the 10-methylgroup (Probable).  Conjugate addition of C-4a-OH to the resulting paraquinone by the monooxygenase dmxR10 then gives cyclohexadienone, which is then reduced at C-5 by the short chain dehydrogenase dmxR3 to give the dihydroxanthone (Probable).  The 6,7-epoxide in the cryptosporioptides could be introduced by the cytochrome P450 monooxygenase dmxL3 (Probable).  The highly reducing PKS dmxL2 manufactures butyrate, which is further carboxylated by dmxL1 to form ethylmalonate (PubMed:30996871).  It is not yet clear whether the carboxylation occurs while the butyrate is attached to the ACP of dmxL2, but this unusual fungal metabolite could then be esterified to O-5 by the O-acetyltransferase dmxR13 (PubMed:30996871).  Finally, dimerization performed by dmxR5 gives the observed dimers cryptosporioptides A, B and C as the final products of the pathway (PubMed:30996871).
What are the official names of this protein?
Anthrone oxygenase dmxR16, Dimeric xanthone biosynthesis cluster protein R16.
What is the protein family that this protein belongs to?
Belongs to the anthrone oxygenase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ACPM_MYCBO
Sequence: MPVTQEEIIAGIAEIIEEVTGIEPSEITPEKSFVDDLDIDSLSMVEIAVQTEDKYGVKIPDEDLAGLRTVGDVVAYIQKLEEENPEAAQALRAKIESENPDAVANVQARLEAESK
What is the function of this protein?
Acyl carrier protein involved in meromycolate extension.
What are the official names of this protein?
Meromycolate extension acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LECM1_PSEPL
Sequence: MGQFTVVSLGLLAMFLSLSGAKGDNCPASWISRNGVCNKLFPDRKTWLEAEKRTWKWSDRTSANYFSWNQGEPNDVQDNENCVHLWAPSGYLKWNDEPCASLHPFICQYKL
What is the function of this protein?
Mannose-binding lectin which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids.  May be a calcium-dependent lectin (By similarity).
What are the official names of this protein?
C-type lectin lectoxin-Enh1, CTL.
What is the protein family that this protein belongs to?
Belongs to the true venom lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CRNS1_CHICK
Sequence: MISVDRLSEEQALGMKEQEWAGPEALCPGWQEEEVSDGEGPEDSGHPDPTAHAYEVLQHTLRLEGMPLTIDRTGQPRTGSGPLDMTVCVLGSPTAFLPVLLEGGTRYPGAMVLCLAPAWASRVPSETSPGSWSLLLSRGVSFEAGGCTALEEFVPPRRATYVTGTFGSEGSWEGELARDLDCPTGGSALLTRWLEDPLLSRWLLSARAGLPVPPTLAFITGLWETLPEEPEPPGVHLVRLQDPQGQESLVRDEVGAFLEGSSMQPYDQVAVRLSGWRWRGTDPHSTHRKVEGEAVAQAVAALLKGLREEESILLEALVPTARLPTLPPRSAAPRLPMALRICTVVCRSWGDRPQLCQVACTAGRAEVPVRHGSALPLGLDSSLRQWGLADAAQRQALAGQLREAAEAAMAALLAAEGELSPAQRGGARAHTDVLGVDFLLACVDGTLELVALSANCLRCLETCLLAEGMGHDVGQPAGDVPRLLAECLLHRAQCHLVEGKDILLIGAGGVSKSFVWEAAREYGLRIHLVESDPEHFAAGLVETFLPYDSREHRRDEEHAERVLEMLRARGLRPDACLSYWDDCVVLTALLCQRLGLPGCPPAAVRLAKQKSRTHQHLQRCRRGRPPPAAFSVPCRRLRSHGDVERAAGAVPFPAVAKLEFGAGAVGVRLVENAGQCHAHAAQLWHDLRADADHPGIGLGWGNAMLLMEYVPGTEHDVDLVLFEGRLLGAWVSDNGPTRVPTFLETAATLPSCLPADRQAQLVRAALRCCRACGLRHGVFNVELKLSPAGPRLLEINPRMGGFYLRDWMRAVYGPDLLLAAVLLALGLPPVLPSRPAPRQQLAGVMCLASEHGRALRGGVMAALQGLQRRGLVRLNPLFEEAGGRYEEPCLSVACAGDGPAEACGRLLGLCQALGIDSPQYPVGHFLSHFK
What is the function of this protein?
Catalyzes the synthesis of carnosine and homocarnosine.  Carnosine is synthesized more efficiently than homocarnosine.
What are the official names of this protein?
Carnosine synthase 1, ATP-grasp domain-containing protein 1.
Protein: PROB_STRU0
Sequence: MMKRNFDQVKRIVIKIGTSSLVQENGKINLEKIDQLAFVMSSLKNKGKDLILVSSGAMGFGLDILKMDKRPSDLAKQQAVSSVGQVAMMSLYSQIFSHYQTNVSQILLTRDVVIFPESLANVTNAFESLMAMGIVPIVNENDAVSVDEMDHATKFGDNDRLSAVVAEITKADLLIMLSDIDGLYDKNPTIYEDAQLRSIVTEITDEIIKSAGGAGSKFGTGGMLSKIQSAQMVFANNGQMVLMNGKNPRDILRVLEGKEIGTWFVQEKGN
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_MARN8
Sequence: MAQVNMRDLLKAGAHFGHQTRYWNPKMSKFIFGARNKIHIINLEQTVPAMNEALNFIQSLAENKNKILFVGTKRAASKIIKEEAQRSGQPYVNHRWLGGMLTNYKTIRQSIRRYRDLEAQSQDGTFDKLTKKEALERTREMDKLERSIGGIKDMGGLPDALFVIDVDHERIAIKEANKLGIPVIGVVDTNSDPDGVDYVIPGNDDAIRAIQIYVKAVADTCLEASQSAGAGADEFVEVSEDAAGAAPAAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PLSX_PARMW
Sequence: MPPKDPDSSRTPESRSKSNRPRAIRRLVIWYRRNAAVTSLVDTATSSASAAGTVAGTVANSMLQPLVFDPLRWLQGNTDDEEIQEADRLWVAVDGMGGDHAPGPILEGCLEAIERLPLKIRFVGETDKVLEAADALGLSERLAQAQAADHLDLVASGPSIGMDDEATAVRRKRDASINLAMDLVKKGQALAVYSAGNSGAMMASAIFRLGRLKGIDRPAIGALFPTKDPGQPVLVLDVGANMDCKPAYLHQFALLGNIYSRDVLQVEQPRIGLLNIGEEDCKGNDLALKTHALLRDERRLHFAGNCEGRDVLSGAFDVVVCDGFTGNVLLKFLESVGSVLLGVLRAELPRGRRGKVGSAFLRSNLRRIKKRLDHAEHGGALLLGVNGVAVIGHGSSKALSVVSALRIAHSAASHGVMEDLAALQSGCD
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity).
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: FLGI_MAGSA
Sequence: MKPFARRALLTAEPIRALLLAASLLAATLGLMPAEAFGASRIKDIADFEGVRDNMLVGYGLVVGLNSTGDSLTNAPFTKESLTGMLERLGVNIRDKTGAISSQLTPKNVAAVMITATLPPFSRQGTRIDINVSAMGDAKDLRGGTLLVTPLIGADGEVYAVGQGQVATGGFTASGASGSSVTKGVPTAGRIANGAIVERELPFEMSHLESVKVSLRNPDFTTSRRIAQAINSFLGGDMARPVDPGTVQIAVPPGYRGNVVGLLTDVEQLRVEPDQMARVVVDEVSGTIVMGENVRISTVAIAQGQLTIRITETPQVSQPSPFSDAGTTTTVQRTDIQVDEGAGNKLAVVPHKVTLQELVEGLNSLGIGPRDLITILQAIKAAGALQAELEVL
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: VME1_CVP67
Sequence: MSSPTTPVPVISWTADEAIKFLKEWNFSLGIIVLFITIILQFGYTSRSMFVYVIKMVILWLMWPLTIILTIFNCVYALNNVYLGFSIVFTIVAIIMWVVYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGRMYVRPIIEDYHTLTATIIRGHLYIQGIKLGTGYSLSDLPAYVTVAKVTHLCTYKRGFLDRIGDTSGFAVYVKSKVGNYRLPSTHKGSGMDTALLRNNI
What is the function of this protein?
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
What are the official names of this protein?
Membrane protein, M protein, E1 glycoprotein, Matrix glycoprotein, Membrane glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses M protein family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer.