PharMolix/UniProtQA huggingface dataset:
Protein: Y3401_MYCTU
Sequence: MITEDAFPVEPWQVRETKLNLNLLAQSESLFALSNGHIGLRGNLDEGEPFGLPGTYLNSFYEIRPLPYAEAGYGYPEAGQTVVDVTNGKIFRLLVGDEPFDVRYGELISHERILDLRAGTLTRRAHWRSPAGKQVKVTSTRLVSLAHRSVAAIEYVVEAIEEFVRVTVQSELVTNEDVPETSADPRVSAILDRPLQAVEHERTERGALLMHRTRASALMMAAGMEHEVEVPGRVEITTDARPDLARTTVICGLRPGQKLRIVKYLAYGWSSLRSRPALRDQAAGALHGARYSGWQGLLDAQRAYLDDFWDSADVEVEGDPECQQAVRFGLFHLLQASARAERRAIPSKGLTGTGYDGHAFWDTEGFVLPVLTYTAPHAVADALRWRASTLDLAKERAAELGLEGAAFPWRTIRGQESSAYWPAGTAAWHINADIAMAFERYRIVTGDGSLEEECGLAVLIETARLWLSLGHHDRHGVWHLDGVTGPDEYTAVVRDNVFTNLMAAHNLHTAADACLRHPEAAEAMGVTTEEMAAWRDAADAANIPYDEELGVHQQCEGFTTLAEWDFEANTTYPLLLHEAYVRLYPAQVIKQADLVLAMQWQSHAFTPEQKARNVDYYERRMVRDSSLSACTQAVMCAEVGHLELAHDYAYEAALIDLRDLHRNTRDGLHMASLAGAWTALVVGFGGLRDDEGILSIDPQLPDGISRLRFRLRWRGFRLIVDANHTDVTFILGDGPGTQLTMRHAGQDLTLHTDTPSTIAVRTRKPLLPPPPQPPGREPVHRRALAR
What are the official names of this protein?
Uncharacterized glycosyl hydrolase Rv3401.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 65 family.
Protein: ATP8_CHAPE
Sequence: MPQLNPNPWFFIMLLSWLTFSLIIQPKLLSFTPTNPPSNKTTTHTKTTPWTWPWT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: PYRD_COXB1
Sequence: MIYRYLRPWLFKLEPETAHALTLNCLKWFYCYWLINRRLQRFPQKPTVVFGIEFPNPVGLAAGLDKNGEYMDELLGLGFGFIEVGAVTPKPQPGNSKPRIFRLPQARALINRMGFNNLGVDYLVEQLKRRKVKGIVGVNIGKNLTTPLEKAHEDYQNCFEKLYSYVDYVTINISSPNTPELRQLQSERYLADLLTRLKEDQRRLEDQYHKRVPLFLKIAPDLTPEEIQTIATLALQHRIEGIVATNTSCSRQGTEKLPNANEAGGLSGKPLFPMTLQVVKQLHSFLGDEIPIVAVGGIFSGENAQTLINAGARLVQLYTGLIYEGPELVKNIVEFLTLSRQTREGIN
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: COX18_MOUSE
Sequence: MLCRSCAGWLRSLPTLRLPAPGSPPAWSSARLPALPVWAAASVSAASPGGWYEALAASAPVRTAEEVLLGAQEATGLPWWSNIILSTVALRGAVTLPLAAYQHYILAKVENLQPEIKDIAKRLNQEVAVCARQFGWSKRVARLTYLKNMRRLISELYVRDNCHPFKATVLVWVQLPMWVFISVALRNLSTGATHSDGISVQEQLAAGGTLWFPDLTAVDSTWILPVSVGVVNLLIVEIFALQKIGTSRFQMYVTNFVRAVSVLMIPVAATVPSALVLYWLCSSLMGLAQNLLLRSPGFRQLCRIPPSKSDSETPYRDLSAAFCAKFLSRKR
What is the function of this protein?
Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane.  Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2.  Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase).
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX18, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS3_BORPA
Sequence: MGQKIHPTGFRLAVTRNWTSRWFADDKAFGTMLAEDIRVREYLKKKLKSASVGRVIIERPAKNARITVYSARPGVVIGKRGEDIENLKADLQRLMGVPVHVNIEEIRKPETDAQLIADSISQQLEKRIMFRRAMKRAMQNAMRLGAQGIKIMSSGRLNGIEIARTEWYREGRVPLHTLKANIDYGTSEAHTTYGVIGIKVWVYKGDMLANGELPPEAATPREEERRPRRAPRGDRPDGARTGRPGGRGRGPRKADAAPAPEGE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: H3_ASPFU
Sequence: MARTKQTARKSTGGKAPRKQLASKAARKAAPSTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVEAYLVSLFEDTNLCAIHAKRVTIQSKDIQLARRLRGERS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DOM34_SCHPO
Sequence: MKLIQKNIEKNGSGWITMCPEEPEDMWHLYNILQVGDQLKASTVRRVVKVGATGSTSGSRVVMKLRILVENMDFDTKAAQLHIKGRTTEYHPEVKMGSYHTLDLELHRNFTLYKNEWDAFALDRVDAACNPSRNAEIGAVVLDEGLANICLITDYMTILRQRIDQVIPRKRRGDSSAYQKGLDKFYDSVFQSINSEFDFDKLKVVILASPGFVARGLYDYIFSMAVKLDLKQIVKSKNKFVILHSSTGHIHSLNEILKDPAVESKLADTKYVQEIRVLNKFYDVMNEDDRKAWYGPNHVLKAFELGAIGELLISDSLFRSSDIATRKKWVSLVEGVKEINCPVYIFSSLHESGKQLDLLSGIAAILTYPVDEEDISEDEEDEESQNFEHS
What is the function of this protein?
Involved in protein translation.  Together with hbs1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.  The complex formed by dom34 and hbs1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA.  Acts as endonuclease; has no exonuclease activity.  Increases the affinity of hbs1 for GTP, but nor for GDP.  Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions.
What are the official names of this protein?
Protein dom34.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPF_YERPY
Sequence: MRIGHGFDVHKFGENGSGPLIIGGVRIPYEKGLLAHSDGDVALHAATDALLGAAALGDIGKLFPDTDPAFKGADSRGLLREAYRRILAKGYKLGNLDITIIAQAPKMAPHIPQMRVNLAEDLQCHMDDINVKATTTEQLGFTGRGEGIACEAVVLLVNVEQG
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: Y460_ARCFU
Sequence: MDEKTLAKMIEAVNKHMPEKTRSLAEMLKEKDPTIRAKDGNEYYIEKRELEFIAQHVDELDWPRFRIPVILEMNDIGGERVIYVRDKLHAEFIKRAFGFDRVLNGILTLYMYELPQIRRKLRTASQVIFRISLK
What are the official names of this protein?
UPF0216 protein AF_0460.
What is the protein family that this protein belongs to?
Belongs to the UPF0216 family.
Protein: RM41_CAEEL
Sequence: MKLVLVSTRGVRSLNSTNFPAPWPFVKKGAFGQRKIGPMNYEKFKWPGQNREFPELSPKFQKLNPKELHRYTGVQADGFHDEKTGEFVPVKEMRSELVVPNLDGFKLRPYVSYRTDVQIEKRRVAYEKKVLEKGSERLADLHTVEDERWPPPKMSAETLFELAYGDTVRSAYKEGKYGNK
What are the official names of this protein?
39S ribosomal protein L41, mitochondrial, L41mt, MRP-L41.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL5_CHRSD
Sequence: MANLKERYQNEVAAQLQEQFSYANVMQIPRITKVTLNMGIGDATSDKKLIDNAMGDLEKLSGQRPVITKARKSIAGFKVREGWPIGIKVTLRSERMWDFLDRLVNIAIPRVRDFRGLNPKSFDGRGNYSMGVREQIIFPELEYDKIDRIRGLDVTITTTANTDEEGRALLSALNFPFKK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: EGL9_CAEEL
Sequence: MSSAPNDDCEIDKGTPSTASLFTTLMLSQPSSSTAVLQCTYCGSSCTSSQLQTCLFCGTVAYCSKEHQQLDWLTHKMICKSLQTSGMVPSNLMPQAAPAVMAPIPPTVSFDDPALTTSLLLSLQNNPILNQTISNFPPTFSITSKTEPEPSIPIQIPQRISSTSTVPFSSEGSAFKPYRNTHVFNSISSESMSSMCTSHEASLEHMSSASLAMFPTSSTAQSDISRLAQVLSLAGDSPASLALVTTSVPSTASTATIPPPATTTSSATSSGKSETITVGKEKIIQTDDPDIQIIETEGGSKPTVSRTRKRPTPSNSADPKINYKDHNKNVVYSTTLQEHQKHLQNRGLALSIHQAMVLRLRYIAEHVIRSLNEFGWAVVDNFLGSDHYKFTAKEIERLYERGLFSPGQLMEAKHKDEFHIKDIRSDHIYWYDGYDGRAKDAATVRLLISMIDSVIQHFKKRIDHDIGGRSRAMLAIYPGNGTRYVKHVDNPVKDGRCITTIYYCNENWDMATDGGTLRLYPETSMTPMDIDPRADRLVFFWSDRRNPHEVMPVFRHRFAITIWYMDKSERDKALAKGKESDAACASKKENDPTSSSLNSLIGSLLRPRKNPSTHDLSKLDLRLFPSTSSDPALVSAADEDRVDISADFQSTSSLAHPESTDSGVSLSTFNVAHNHMERTTSLQSISDHFRSERSHERRSSTSSDQDLDEGLPPPPSTNPEYYI
What is the function of this protein?
Regulates the trafficking of the glutamate receptor glr-1, probably independently of hif-1, by regulating lin-10 subcellular localization in response to oxygen levels.  May hydroxylate lin-10.
What are the official names of this protein?
Hypoxia-inducible factor prolyl hydroxylase, HIF-PH, Egg-laying defective protein 9, Hypoxia-inducible factor-proline dioxygenase.
What are the subcellular locations of this protein?
[Isoform a]: Cytoplasm. Nucleus. Cell projection, dendrite. Note=In interneurons, localizes throughout the ventral cord dendrites. SUBCELLULAR LOCATION: [Isoform c]: Cytoplasm. Nucleus. Cell projection, dendrite. Note=In interneurons, localizes throughout the ventral cord dendrites. SUBCELLULAR LOCATION: [Isoform e]: Cytoplasm. Nucleus. Cell projection, axon. Note=In interneurons, localizes in puncta (which probably correspond to endosomes) along the ventral cord. Localization to puncta is regulated by oxygen levels. Co-localizes with lin-10 in puncta.
Protein: PAND_XYLFA
Sequence: MQLSLLKAKIHRATVSHSELNYEGSIAIDGLLLEAAGLYEFEKVHIWNVTNGARFTTYAIRAEHGSGIISVNGGAARYVQVGDLVIVAAFAQMSEDEAAVFSPNLVYVDAANAMTHTNHSIPTQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_BUCUO
Sequence: MKTQYRIAVLPGDGIGPEVMREAYKILKILKNNFLLSFEIEEFNVGGIAIDQEGLALPKKTLLGCEKSDAILFGSVGGKKWDNFPIEERPERAALLPLRKHFNLFANLRPAKIYSELKHLSPLRSNIVRDGFDILCIRELTGGIYFGQPSGRRLEKNNIEYAFDTEIYYDYEINRIAHLAFQLAQSRSHKVCSIDKSNVLNSSILWKEIVQKVSKNYPDVDLSHLYIDNAIMQIIKNPNQFDVLLCPNLFGDIISDECAIITGSIGMLPSASLNEKKFGLYEPAGGSAPDIAGKNIANPIAQILSLSMLVRYGMNLKDIADKIDKSVLSVLKKGYRTADISNNNNYLKTNEMGDVIANALISGE
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2181_TOLAT
Sequence: MSKKNTLDDQDVSLFREAIAGARPIKQDTIRLHSPAIKQKAQIREIRETQQALHYFSDEYEPLLNQDGPVKYCRADVSTYEVKKLRRGDYIPDMMLDLHGLTQQQAKSELAALIEACRRQHIRCACVMHGHGKNILKQRIPLWLAQHPDVMAFHQAPKLWGGDAAILVLIEQNI
What are the official names of this protein?
UPF0115 protein Tola_2181.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: Y4128_BACC2
Sequence: MAKDSSFDIVSKVELPEVTNAINIALKEIQNRYDFKGSKSDIKLEKEVLVLTSDDEFKLDQVKDVLISKLVKRNVPIKNLDYGKVEAATGNTVRQRATLQQGIDKDNAKKINNIIKEMKLKVKTQVQDDQVRVTAKSRDDLQAVIAAVRSADLPIDVQFINYR
What are the official names of this protein?
UPF0234 protein BCG9842_B4128.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: CASP1_POPTR
Sequence: MKSESAAIDIPESSSVAKGKAPLIAVSRNEKGGYRKGIAIFDFILRLAAIATALAAAAAMGTSDETLPFFTQFFQFQASYDDLPTFQFFVIAIAIVGGYLVLSLPFSIVAIVRPHAVGPRLLLIILDAVALTLNTAAGAAAAAIVYLAHNGNSNTNWLAICQQYGDFCQKVSGAVVASFITVVIFVFLIVLSAFALRRH
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 1, PtCASP1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: PPR3C_MOUSE
Sequence: MSCTRMIHVLDPRPLTSSVMPVDMAMRICLAHSPPLKSFLGPYNGFQRRNFVNKLKPLKPCLSVKQEAKSQSEWKSPHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSSLKLHEEKNLVFDFPQPSTDYLSFRDRFQKNFVCLENCSLQDRTVTGTVKVKNVSFEKKVQVRITFDTWKTYTDVDCVYMKNVYSSSDSDTFSFAIDLPRVIPTEEKIEFCISYHANGRIFWDNNEGQNYRIVHVQWKPDGVQTQVAPKDCAFQQGPPKTEIEPTVFGSPRLASGLFPEWQSWGRVENLTSYR
What is the function of this protein?
Acts as a glycogen-targeting subunit for PP1 and regulates its activity.  Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.  Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 3C, Protein phosphatase 1 regulatory subunit 5, PP1 subunit R5, Protein targeting to glycogen, PTG.
Protein: CHEY_ECOLI
Sequence: MADKELKFLVVDDFSTMRRIVRNLLKELGFNNVEEAEDGVDALNKLQAGGYGFVISDWNMPNMDGLELLKTIRADGAMSALPVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEKLGM
What is the function of this protein?
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.  In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation.  Overexpression of CheY in association with MotA and MotB improves motility of a ycgR disruption, suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein and the flagellar stator.
What are the official names of this protein?
Chemotaxis protein CheY.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCS2_RALSO
Sequence: MSLEPFAKSEALTFGVELELQLVNRHDYDLASASADLLRMLRGKETPGDIKPEITESMIEIATGICHSHDEALWQMREIRDRMVEAAVPLNIGICGGGTHPFQQWSQRTISASPRYQYISELYGYLAKQFTVFGQHVHLGCPSPDDALYLLHAMSRYVPHFIALAASSPFVQGVDTGFASARLNSVSAFPMSGRAPFVLTWDAFVAYFEKMRATGVIESMKDFYWDIRPKPEFGTIEVRVMDTPLTVERAAAVAAYIQALGRWLLLDRPFVPTEDDYLVYTFNRFQACRFGLVGEYVDPASGQRGALADHILETSKLLAPHAEALASEGALDMVREVVERRDSDAEWIRATEGETRNLHETVRRGCGRWAQVASLPA
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: SYR_RICCN
Sequence: MNIFNQLKQDIIVASRQLYNNQEIANTATIEIPKDSFNGDLSSNIAMIIAAKESIAPREVALKFKEVLITLPYIASIEIAGPGFINFTIKADSWQASIKDILQHEEKFFEIDIDKSRNINIEYVSANPTGPMHIGHARGAVYGDVLARILQKVSYSVTKEYYVNDAGSQINDLVSTVLLRYKEALGEQITIPAGLYPGEYLIPLGQILAKEYGNKLLTMNYAERFKIIKSFAVEKMLDLNRKDLADLGIKHDIFFSEQSLHDKGEIEETVKLLERMGLIYEGTLPAPKGKIHEEWDNRVQKLFKSTKYGDSQDRPIEKADGSWSYFASDLAYAKDKIERGANHLIYVLGADHSGYVKRIEAIVKALGKEQVKVDVKICQLVNFVENGVPVKMSKRLGSFASVQDVNHEVGKDIIRFMMLTRQNDKPLDFDLVKVKEQSRENPIFYVQYAHVRTISILSKAKELMPESYNNFESGKYDLSLLSSEEEIEIIKLLASWTKTLEASAKYFEPHRIAFYLINLASKFHSMWNFGKENSDYRFVIESNKELTLARLALASAIQKVIASGLEVIGVEPMNKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP_SHISS
Sequence: MSTDNKQSLPAITLAAIGVVYGDIGTSPLYTLRECLSGQFGFGVERDAVFGFLSLIFWLLIFVVSIKYLTFVMRADNAGEGGILTLMSLAGRNTSARTTSMLVIMGLIGGSFFYGEVVITPAISVMSAIEGLEIVAPQLDTWIVPLSIIVLTLLFMIQKHGTAMVGKLFAPIMLTWFLILAGLGLRSIIANPEVLHALNPMWAMHFFLEYKTVSFIALGAVVLSITGVEALYADMGHFGKFPIRLAWFTVVLPSLTLNYFGQGALLLKNPEAIKNPFFLLAPDWALIPLLIIAALATVIASQAVISGVFSLTRQAVRLGYLSPMRIIHTSEMESGQIYIPFVNWMLYVAVVIVIVSFEHSSNLAAAYGIAVTGTMVLTSILSTTVARQNWHWNKYFVALILIAFLCVDIPLFTANLDKLLSGGWLPLSLGTVMFIVMTTWKSERFRLLRRMHEHGNSLEAMIASLEKSPPVRVPGTAVYMSRAINVIPFALMHNLKHNKVLHERVILLTLRTEDAPYVHNVRRVQIEQLSPTFWRVVASYGWRETPNVEEVFHRCGLEGLSCRMMETSFFMSHESLILGKRPWYLRLRGKLYLLLQRNALRAPDQFEIPPNRVIELGTQVEI
What is the function of this protein?
Responsible for the low-affinity transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Low affinity potassium transport system protein Kup, Kup system potassium uptake protein.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL30_BREBN
Sequence: MAKLQITLKRSLIGRTVDQQDTVKALGLRKINSTVVKEDNPAIRGMVFKVKHLVEVKEVEA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RL35_SALTO
Sequence: MPKMKSHTGMGKRVRVTGKGKIVKQQAGLRHNLEKKSSTRTRRLTGLVEVAKPDVKRIKKLLGR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: PUR9_BURL3
Sequence: MIKQALISVSDKTGIVDFAKSLSDLGVKLLSTGGTAKLLADAGLPVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRDLPEHMQALEQHGIPTIDLLVVNLYPFVATIAKDDCTLADAIENIDIGGPTMLRSAAKNHRDVTVVVDPADYAVVLDEMKANGNAVGYATNFRLATKVFAHTAQYDGAITNYLTSLTDELKHASRSAYPATLNLAFDKVQDLRYGENPHQSAAFYRDLATPAGALANYRQLQGKELSYNNIADSDAAWECVKTFDAPACVIIKHANPCGVAVGNDSADAYAKAFQTDPTSAFGGIIAFNREVDEAAAQAVAKQFVEVLIAPSFSDAAKQVFAAKQNVRLLEIALGDGHNAFDLKRVGGGLLVQSLDSKNVQPSELRVVTKRQPTAKEMDDLLFAWRVAKYVKSNAIVFCGNGMTLGVGAGQMSRVDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVAAGATCVIQPGGSMRDDEVIAAADEHNIAMILTGVRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: UCSK_ACRSP
Sequence: MALLNTPVLAAATAVSFGFYLAGLFVYRVFYHRLSHIPGPRLAAFTVYYQSYYDFFPHQGQFLWKLVELHKAYGPIIRIGPDEVHVNDARFYKEMYGSSVHKRNKSPIWYWMDGLGAVGDQSMFITLDHDHHRLRKAGLGTYFSKRKVQELEPRVKEKVLLLRQRLLERAGRGAINLKDAFGGMALDIITQYCFNQCMGALDRDDLGREWNQLMAAGVKINPFARTFPTVARTLLRLPKWVLGVSGMVSTTGEFLDLADRLSANARNEAIRDLQEGKYTLTDDADSRTVLHSMMRSDVLPEHEKGERRLQADGMTLIAAGFDTTSRTLTVVFYHLLAKPAMRARVLEEIRTLMPTPSSPLPTVAQLEQLPYLTCVIHEGTRLAHGVAGRLVRIAPEEDLVYHNSSDDTEYTIPRGATFGQSSYLVHTDESIYPNPHDFIPERYWSDDGKPTDAERYLVAFGKGTRMCSGINLAFAELYLTIAALLGAVDMKLAPGTTEHDVSLVAELFVGVLPESPGVRVNVVGSL
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of UCS1025A, a member of the pyrrolizidinone family that acts as a strong telomerase inhibitor and displays potent antibacterial and antitumor properties (PubMed:29373009).  These compounds share a hemiaminal-containing pyrrolizidinone core fused with a gamma-lactone, giving a furopyrrolizidine that is connected to a decalin fragment (PubMed:29373009).  The polyketide synthase module (PKS) of the PKS-NRPS ucsA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:29373009).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with a 2S,3S-methylproline derived from L-isoleucine by the 2-oxoglutarate-dependent dioxygenase ucsF which converts L-isoleucine to (4S,5S)-4-methylpyrroline-5-carboxylate that is further converted to 2S,3S-methylproline by the pyrroline-5-carboxylate reductase ucsG (PubMed:29373009).  Reductive release of the completed aminoacyl polyketide from the assembly line can form the 3-pyrrolin-2-one structure via an intramolecular Knoevenagel reaction (PubMed:29373009).  Because ucsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase ucsL (PubMed:29373009).  This keto acyclic precursor is the substrate of the Diels-Alderase ucsH, that catalyzes the Diels-Alder cycloaddition (PubMed:29373009).  Oxidation of the 3S-methyl group to a carboxylate by the cytochrome P450 monooxygenase ucsK allows an oxa-Michael cyclization that might involve the reductase/dehydrogenase ucsI and which furnishes the furopyrrolizidine (PubMed:29373009).  The oxidase ucsJ likely plays a critical role in stereoselective reduction of the C5-C6 double bond to afford the required R-configured carboxylate group (Probable).  Further enolization and oxidation at C5 by an unidentified enzyme affords the last intermediate that can undergo oxa-Michael cyclization to yield UCS1025A (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase ucsK, UCS1025A pyrrolizidinone biosynthesis cluster protein K.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IF1_LEPIN
Sequence: MAKEEAITVDGTVLEPLPNAMFRVELENGHKVLAHISGKMRMHYIRILPGDKVTVELSPYDLSKGRITYRKK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.