PharMolix/UniProtQA huggingface dataset:
Protein: AROB_STAES
Sequence: MELKTSYASDNYPIIVKHHAINSLERYIKNEEQRFFIIDKQVYNLFVDKLEALAQKFDAKCIVIPSGETSKSFEHYHRTIEYLLSHQLTRQTCIVAIGGGATGDFAGFIAATLLRGVSFVQVPTTILAHDSSVGGKVGINSEHGKNLIGAFYRPKAVIYDLDFLETLPYSEILSGYAEVYKHALLNGEKSTKNIESNFTSNKVLQALKNLDYYLFEGIKTKLNIVVEDEKEKGKRKFLNLGHTFGHAIEYEHKIPHGHAVMIGILYQFIVANHLFETNYNIQHYINYMKKLKYPLSIIKQLHFEDTYHFMLLDKKNDYNGIQMVLLKNLGKPVVTHVDKDTLLSAFEELQSYFK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4310_AFIC5
Sequence: MTDPWRYATHGVMVAVRVTPRGGRDAVDGIEMLANGKSVVKVRVRVAAEGGEANRAVTELFAGLLRVPKSKVKVASGVTSRIKQIAIEGDPKQLGEALKAATSIES
What are the official names of this protein?
UPF0235 protein OCAR_4310/OCA5_c02140.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: MLAB_HAEIN
Sequence: MLNWDLQKNNDKITLFLFGELSRSTLLPMWQQRGVFLSASTLDKTIVEWNLSDLQHIDSAGFAALCDFLRECQKLNKTVRLVYPPKQLLTLADLFGLSDWIANFI
What is the function of this protein?
Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane.  MlaB plays critical roles in both the assembly and activity of the complex.  May act by modulating MlaF structure and stability.
What are the official names of this protein?
Intermembrane phospholipid transport system binding protein MlaB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSTL1_MOUSE
Sequence: MEMKARGLRIPLLLLLVTVVVMAKVNHIQRWGGFKEKAMSKKNINSTLHFFIRSYNNASNDTYLYQVQKLIQGQMQLTTGVEYLVTVKIGRTKCKKNETKKASCPLQSSKLKKSLICKSLIYSVPWMNYYQLWNNSCQES
What are the official names of this protein?
Cystatin-like 1.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: UBP22_MOUSE
Sequence: MVARPEPEVEAMDAELAVPPPGCSHLGSFKVDNWKQNLRAIYQCFVWSGTAEARKRKAKSCVCHVCGIHLNRLHSCLYCVFFGCFTKKHIHDHAKSKRHNLAIDLMYGGIYCFLCQDYIYDKDIEIIAKEEQRKAWKMQGVGEKFSTWEPTKRELELLKHNPKRRKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKGDDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSSTPFWPLSPGSEGSVVNGESHASGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDMTPFMASSKESRMNGQYQQPLDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLDSEGYLLFYHKQFLEYE
What is the function of this protein?
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA.  Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator.  Recruited to specific gene promoters by activators such as MYC, where it is required for transcription.  Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 22, Deubiquitinating enzyme 22, Ubiquitin thioesterase 22, Ubiquitin-specific-processing protease 22.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. UBP8 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLGX_HAEIN
Sequence: MFKIYNNGNPIPMGYSQAVENNVQITNFALFSAAAIGVELCLFDEQNQETRLPMVRTENVWHLAVTGVKTGTEYAFRIHGEFANPQKLILDPYAKAVNGKPDLSSEESRSWFLLSDNRDNAHLAPRAVVISEEFDWENDTSPNTPWAETIVYELHVKGFSQLNEKIPAALRGTYTGLAHPVNLAYLKELGVTAVELLPVNFHINEPHLQARGLQNYWGYNPLAMFAVEPKYAATNNPLAEFKTMVKAFHKAGIEVILDVVFNHSAESEQTYPTFSQRGIDDQTYYWRNDQGRYINWTGCGNMLNLSSDVGRKWVVDCLRYWVEQCHIDGFRFDLATVLGRDTPDFNSSAQLFTDIKNEPSLQNIKLIAEPWDIGHYGYQVGNFPSYFAEWNDRFRDDLCRFWLWKSGEIGAFAERFAGSSDLFKKNDRLPHTTLNFITAHDGFTLKDLVSYNQKHNETNGEENRDGRNENYSYNHGVEGSTESLSEPQKSAVENNRTFAQSGLLMSLLLANGTPMLLAGDEFGNTQYGNNNAYCQDNEITWLKWANFNEELFELTKQTIALRKQIGSLNKDQWWSDENVQWLNIVGEPMTVEDWQNQQTKALQVVLDNRWLLLINAKAEGQMFHLPNRKWKPQIGTHNVTLEAQQAELSSMGFCMLNDE
What are the official names of this protein?
Glycogen operon protein GlgX homolog.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: LPXB_SALG2
Sequence: MAAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTRRFTELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRSTHMVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDLEVVVPLVNAKRREQFEKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTEYVSLPNLLAGRELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAADAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: FLGK_BUCAP
Sequence: MSSILTSTVTGIDAIKILINNTADKIINSKYKDEIKHNVFVENTVDESNFNAGVKIKKIYDDYNDFLKEEKRKISERVQDEQTKIEEYLKLEDLFGEKSNIFTLLINQLYSSIENDIVNNHGNVFNENIENNLNTIIHELKNFDEKLSFLERDVKESIKEKIKQANILINKIYDTNIDIRFFPTAQLPNRIDSFIDKRDKLIDELNDIIGVKVIKENSTFKVCLNNGMCIIDDYNKKNLMTLTSDTDDKYISVGYFDDNEQRLKKIEHMIPSASLGALLTFRREDLQNAKNKIGQLTINFADSINSVHTLGYDILGNIGKQVFKISNPEIISSSQNQSYLPTSIKWVDTADAQDTNYIVFLKNNHWTVTRLRDHSVVEPDIYQQDNNTYITFDGIEFKIEGNDAEGNMYMIKPYSKTLNELELLIIKNDLFSISSSDDLNQKNRNNAIKIQHLHQEKIVNKKETLYESYLRFLKSISYKCNDLEEKVPFKRNMIEILNNKKLSESDDMYENYQNLNYEQKCYLANVKVLKMAETIFDEIVDCYS
What are the official names of this protein?
Flagellar hook-associated protein 1, HAP1.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: IF3_PROM5
Sequence: MPPRPRFDRRAPVRELPNINERIKYPQLRVVDSDGKQLGVIDRIKALEIANQRELDLVLVSEKANPPVCRIMDYGKYKFEQEKKAKEARKKSHQTEVKEVKMRYKIDKHDYDVRIGQAVRFLKAGDKVKCTVIFRGREIQHSNLAETLLLRMANDLEEQSEVQQRPKREGRNMIMFLSPRKTPLIKKEEDAKENN
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPME1_ASPFU
Sequence: MSDLHKAFAKSKLAKLPPEAPLLSESSSMNHPAESSHDEDSSSVSSTGTVIPSPSRQLFARASQGSSDSSSLSWSDFFAKELFLTRETDTLRIIHHVYLTPPTDSGPLFVMHHGAGSSGLSFATCAEEIRKILPKAGILSLDARDHGRTSVQRTDGGAAELDLSLETLNQDLVYVARKTQAEMGWEELPDLVLVGHSLGGAVITDVAKKGELGNKVLAYAVLDVVEGSAMDALQSMEKYLSTRPSRFPSLTSGVEWHTRSRTIRNRASARVSVPSLLYKEETPSDPAKPWVWRTNLSATKPFWEDWFIGLSRKFLEARGGKLLLLAGTDRLDKELMIGQMQGKYQLQVLPEAGHFIQEDMPAKTAQILVDFYKRNDRSALVLPPKVADMRASAAMQKGAGAGASFSALHGGSSAGHLHKP
What is the function of this protein?
Demethylates proteins that have been reversibly carboxymethylated.  Demethylates the phosphatase PP2A catalytic subunit (By similarity).
What are the official names of this protein?
Protein phosphatase methylesterase 1, PME-1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: ECM14_COCP7
Sequence: MHILQVITGATLVSVPFVSAIPSSTSEFLPSTAEQNSAVLHSQGRSPPRLWTRLRDSIIETIWRVPSRQHNPSRIPSSLSIPRAPSSIRARYGDDVVLRFTIRSQNDVQALIEASNILFLDIWASTNEWVDIRLAKDVVSSLLGLLPSSLRTAHVPIIHDLAQAVYESYPQPVSSVPNPHHAFSPSVQQSSETQNIFFQDYQPLSVIIPWMRLLASMFSTHVRLVNLGTSYEGREIVGFRIGVRPANADLPTERRKTIVITGGSHAREWIGVSTVNYVAYSLITGYGKSRAITKLVEEFDWVLIPTMNPDGYVYTWETDRLWRKNRQENNLQFCPGVDLDRTWGYEWDGSDSRSNPCSEDFAGDGPFGGRESKVIAQWALNETNHHNVTFVGFLDLHSYSQQILYPYSYSCTNIPPTLENLEELAIGIAKAIRLTDHEHYDVSSACEGSVSSHKKRRGAALRSMQSAGGSALDWFYHDLHVRYAYQLKLRDKGGYGFLLPKKNIVPTGKEVYNAVLVFGQFLLGRGAQDIDWEGDFQFPAHSRPNVPEKEYRGPDEEYEISNQLEDDDNENDTLLGFRTQKV
What is the function of this protein?
Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.
What are the official names of this protein?
Inactive metallocarboxypeptidase ECM14.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Vacuole. Secreted.
Protein: TNR5_CALJA
Sequence: MFRLPLQCVLWGCLLSSVHPEPPTACREKQYLINSQCCSLCQPGWKLVNDCTEVTETECLPCGKGEFLDTWNRETHCHQHKYCDPNLGLRVQQEGTSVTDNICVCKEGRHCTSKACESCVLYHSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCRPWTRCETKGLAEQQAGTDKTDAVCGPQNRLRLLVVIPIMLGILFAILLVLVFIKKVDRKPQDKAPCTKQIPQEIDDLPGPNPTPPVQETLHGCQPVAQEDGKESRISVQERQ
What is the function of this protein?
Receptor for TNFSF5/CD40LG (By similarity).  Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, CD40L receptor.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MOAC_BURO1
Sequence: MSGLTHFDAAGHAHMVDVGDKQETRRIAIARGTIRMLPATFALIRDGKAKKGDVLGVARIAAIQGAKRTADLIPLCHPLALTRVAVEFELDDALPGVHCVVQVETFGRTGVEMEALTAVQVGLLTVYDMCKAVDRGMVITDVSVREKRGGKSGDWKAEDAAG
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: CINA_STRP2
Sequence: MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGATEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQVQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVRHIAVMHAFNLVRKALLSD
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: LUXS_PHOLL
Sequence: MPLLDSFTVDHTRMNAPAVRVAKTMKTPHGDTITVFDLRFCIPNKQVMPEKGIHTLEHLFAGFMRNHLNGEGVEIIDISPMGCRTGFYMSLIGEPAEVRVADAWKAAMADVLKVKDQSQIPELNIYQCGTYHMHSLTEAQDIAHHILDSDVLVNKNDELALPEEKLTELKV
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: RIHB_SHISS
Sequence: MEKRKIILDCDPGHDDAIAIMMAAKHPAIDLLGITIVAGNQTLDKTLINGLNVCQKLEINVPVYAGMPQPIMRQQIVADNIHGETGLDGPVFEPLTRQAESTHAVKYIIDTLMASDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGNFTPSAEFNIFADPEAARVVFTSGVPLVMMGLDLTNQTVCTPDVIARMERAGGPAGEMFSDIMNFTLKTQFENYGLAGGPVHDATCIGYLINPDGIKTQEMYVEVDVNSGPCYGRTVCDELGVLGKPANTKVGITIDTDWFWGLVEECVRGYIKTH
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.  Has a clear preference for cytidine over uridine.  Strictly specific for ribonucleosides.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihB, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihB subfamily.
Protein: KRE28_YEAST
Sequence: MDTGSASIKDYETVLTDIEDSIAVSSEEVLNNQELRLKNTLHEITSSILAINEENKFVNPLRNDESLDVEGKEVFVNPKILSAKIKEFNKLMELLKLTYLEQETLDYFFRFTLSSTKPLQLDSEKDPQFVKLNERVNDLKEEISNVQESKIEQIKAEIQETGHNFAERQDLINELYLEATGDIENCWDSLNELKNLTNKEDKNMMGEKDTILNSSDSDDFVEETYTNWQKLLFLQKQNQRLTKELKEMHEVKNQIIRKGEQSKKEDSGHLMANESELCQSINLLTKFWEKHFLLKGSKTTILNFEIFTQLGKVQFEIKDMQYIIAISLSDLKRPMIKDITILQKAGGNIVTDIEASSKFNNKYRNNTKVQIFEVMDDIISELTNE
What is the function of this protein?
Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3).  Involved in kinetochore-microtubule binding and the spindle assembly checkpoint.
What are the official names of this protein?
Spindle pole body component KRE28.
What is the protein family that this protein belongs to?
Belongs to the KRE28 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Chromosome, centromere, kinetochore. Note=Localizes to the nuclear side of the spindle pole body.
Protein: RT11_ARATH
Sequence: MNGVSRHLRASSLLSLIRSYGGINSVCRFSSQSDGFSGGRFREQVPVSGESANNSGLSNTGRIGSSPEPNPSTLRTFGDMKAGLLNRGVNGFSAPNAPPTFKSSLRSRLPNSLPDQFGQTNPGLPNTGGSGFSAPSLSSYENFTQSSSLLKENSRSGGKSSDLDFVREVIEDEGRRTAGIFSHFQRPNLETNADIIHIKMLRNNTFVTVTDSKGNVKCKATSGSLPDLKGGRKMTNYTADATAENIGRRAKAMGLKSVVVKVNGFTHFGKKKKAIIAFRDGFTNSRSDQNPIVYIEDTTRKAHNGCRLPRKRRV
What is the function of this protein?
Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus.
What are the official names of this protein?
Probable ribosomal protein S11, mitochondrial, MRP-S11, S11mt, Protein NUCLEAR FUSION DEFECTIVE 3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYI_CROS8
Sequence: MSDYKSTLNLPETGFPMRGDLAKREPGMLARWTDDDLYGIIRAAKKGKKTFILHDGPPYANGSIHIGHSVNKILKDIIVKSKGLAGYDSPYVPGWDCHGLPIELKVEQEFGKPGEKFTAAEFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMDFNTEANIIRALGKIIGNGHLHKGAKPVHWCVDCRSALAEAEVEYYDKTSPSIDVAFNAVDAAAVAAKFGAQNVNGPVSLVIWTTTPWTLPANRAISLHAEIDYVLVQIEGQALIVAKDLLESVMKRINVADYTVLGETKGAQLELMRFTHPFMGFDVPAILGEHVTLDAGTGAVHTAGGHGPDDYTISQKYGLEIANPVGPDGTYLPGTYPGLDGVNVFKANDQIVELLREKGALLNVAKLLHSYPCCWRHKTPIIFRATPQWFVSMDQKGLRAQSLKEIKGVQWIPDWGQARIESMVANRPDWCISRQRTWGVPMSLFVHKETQELHPRTLELMEEVAKRVEQDGIQAWWDLDPRDIMGDDADVYEKVPDTLDVWFDSGSTHSSVVDVRPEFAGHAADMYLEGSDQHRGWFMSSLMISTAMKGKAPYRQVLTHGFTVDGQGRKMSKSIGNTVSPQDVMNKLGADILRLWVASTDYTGEMAVSDEILKRAADAYRRIRNTARFLLANLNGFDPAKDMVKPEEMVVLDRWAVGCAKAAQDDIVKAYEAYDFHEVVQRLMRFCSIEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHISEALVRWIAPILSFTADEVWGYLPGEREKYVFTGEWYDGLFGLADTEAMNDAYWDALLKVRGEVNKVIEQARADKKVGGSLEAAVTLYAEPELAAKLTALGEELRFVLLTSQAKVEDYASAAADAQQSELLKGLKVALAKAEGEKCPRCWHYTTDIGKVAEHAEICGRCVSNVAGDGEKRKFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA2_RHORT
Sequence: MTAYTPWTGFFSASVAQADPELDRVLRAELSRQQDQIELIASENIVSRAVLEAAGSVLTNKYAEGYPGKRYYGGCEEVDVAEELAIERAKALFGCSYVNVQPHSGAQANGAVMMALVKPGDTIMGMSLAAGGHLTHGAPPAQSGKWFNAVQYGVRLQDASIDFDEVATLAETHKPKLIIAGGSAYPRIIDFAKFREIADRVGALFMVDMAHFAGLVAAGLHPSPLPYADIVTTTTHKTLRGPRGGMVLSNNPDIGKKINSAVFPGLQGGPLMHIIAAKAVAFGEALRPEFKVYAQAVIDNAKALTDALAAGGLNIVSGGTDTHLALVDLRPKALTGNIVEKSLERANITTNKNGIPFDPEKPAITSGIRVGTPAGTTRGFGTAEFTEIGKLIVEVLDGLAANGEDNSQAEAAVREKVAVLCRRFPIYGGL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 2, SHMT 2, Serine methylase 2.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_RICPR
Sequence: MVRFIFVTGGVVSSLGKGITAASLAMLLQAKGFRVSVRKLDPYLNVDPGTMNPHEHGEVYVTDDGAETDLDLGHYERFTGVTACKCDNITTGAIYSKLLKDERLGNYTGITVQVIPHVTNIIKDFIMSNTNGFDFIICEIGGTVGDIEGLPFFEAIRQIGNKLKNANCLFIHLTLLPYVKTARELKTKPTQHSVKELRAIGISPNILVCRAERNISKSAIDKIALFCNIKPEYVIPAIDQKNIYLVPIAYHNSGLENKVLNFFNINVVPSKLDKWYDIIDKIKDSNSKVKIAIITKYHKTQDAYKSVIEALNHAGIYYKYKIDVLWINAENLTEENINKKLLDINGILVPGGFGVRATQGKMIAIKYARTNNIPFFGICFGMQLATIEIAQNLIGIQDAVTEEFKIKGTKIIEKINKNCEDATIKIKNAHISKCTYSEAFECDASTVYTNIHEDSNNLSTDKLQIETNFRNMSDIEKTMRLGAYPCNLVANTIAANAYKSLEINERHRHRYKFNNEFQNIFEQHGVVFSGFSQNKQIVEIIELPELRWFVGVQFHPEFKSKPFEAHPLFIQFIKATIEYNKSNEQQ
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: AROB_LISMF
Sequence: MPEITVRAKSKTYPVYINEFALEDVREKWTESLAKFSHVFVLTDEHVAELHQAKLDAVLADLPVVTYYVAPNGEEAKTFRVYEDVMTKLIETGLDRKAVLIAFGGGVIGDLGGFVAATYMRGIPFYQVPTTVLAHDSAVGGKVAINHPLGKNMIGNFYQPEAVIYDTQFFATLPEREMRSGFAEMIKHALISDQTLLRALMDTFTEPKDFYTKDLTPFLQRGIEIKANIVAQDETEQGVRAYLNFGHTFGHALEAYGNFGKWLHGEAITYGMIYALTMSETIYGLDFDLAEFKTWLKQLGYDTTFDATVPFNKILENMRHDKKTTFNEISMVLLEEIGEPVIFKAEDDLIFETYKRVMRNGGNGI
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSL3_HUMAN
Sequence: MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
What is the function of this protein?
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490).  Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621).  Has mainly an anabolic role in energy metabolism.  Mediates hepatic lipogenesis.  Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates.  Both isoforms exhibit the same level of activity (By similarity).
What are the official names of this protein?
Fatty acid CoA ligase Acsl3, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 3, LACS 3, Long-chain-fatty-acid--CoA ligase 3, Medium-chain acyl-CoA ligase Acsl3.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: LEXA_THEMA
Sequence: MKDLTERQRKVLLFIEEFIEKNGYPPSVREIARRFRITPRGALLHLIALEKKGYIERKNGKPRALRISKSIRNKIPLIGEIRAGEKREAIEYLEDYIEIPESFLSSGYDHFLLKVKGESMIEEHICDGDLVLVRRQDWAQNGDIVAAMVDGEVTLKKFYQRGDTVELRPANREMSSMFFRAEKVKILGKVVGVFRKL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: SPA_STAAM
Sequence: MKKKNIYSIRKLGVGIASVTLGTLLISGGVTPAANAAQHDEAQQNAFYQVLNMPNLNADQRNGFIQSLKDDPSQSANVLGEAQKLNDSQAPKADAQQNNFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNESQAPKADNNFNKEQQNAFYEILNMPNLNEEQRNGFIQSLKDDPSQSANLLSEAKKLNESQAPKADNKFNKEQQNAFYEILHLPNLNEEQRNGFIQSLKDDPSVSKEILAEAKKLNDAQAPKEEDNKKPGKEDGNKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDNNKPGKEDGNKPGKEDNNKPGKEDGNKPGKEDGNKPGKEDGNGVHVVKPGDTVNDIAKANGTTADKIAADNKLADKNMIKPGQELVVDKKQPANHADANKAQALPETGEENPFIGTTVFGGLSLALGAALLAGRRREL
What is the function of this protein?
Plays a role in the inhibition of the host innate and adaptive immune responses.  Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins (By similarity).  In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region.  In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production.  Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin.  Acts directly as a pro-inflammatory factor in the lung through its ability to bind and activate tumor necrosis factor alpha receptor 1/TNFRSF1A (By similarity).
What are the official names of this protein?
Immunoglobulin G-binding protein A, IgG-binding protein A, Staphylococcal protein A, SpA.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin-binding protein SpA family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A.
Protein: Y2673_VIBPA
Sequence: MRLIVVSGHSGAGKSIALRVLEDLGYYCVDNLPVNLLDAFVHSIADSKQNVAVSIDIRNIPKKLKELTGTLEQLKTELDVTVLFLDANKETLLKRYSETRRIHPLSLGGQSLSLDQAIEREKEILTPLKAHADLILNSSGQSLHELSETVRMRVEGRDRKGLVMVFESFGFKYGLPSDADYVFDVRFLPNPHWEPALRPLTGLDAPIAAFLEQHQSVLSLKYQIESFIETWLPLLEKNNRSYLTVAIGCTGGKHRSVYLTQQIGEYFADKGHQVQIRHTSLEKNAKE
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein VP2673.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.