PharMolix/UniProtQA huggingface dataset:
Protein: RLMH_BRUME
Sequence: MRVSVFAVGRMKSGPERELVERYFDRFAKAGPPLGLEFAGVSEIPESRGQTAQLRKAEEAQRIHEALDNAKSGGAKSGGTSSGGAALILLDERGKTLGSEAFAAIVGRMRDDGKRQLIVAIGGPDGHDPALRSRADLVLALGELTWPHQIARILIAEQLYRAATILAGHPYHRS
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATRX_PI4HA
Sequence: MAPTQSKVRIHNLAEAHEKTLRAFPIEVEQNPEGKKLLVKQIRIRTLGHADHSNDSICFLNTYGFIKEAVSQTEFMRAGQKSESKNTLTACMLPFGPGPNIGSPQKMLEYAEDIKIHVRKTAGCKEQIVFSLDRTPQVFRGFQFPRDRYACVPSDKYIKSPGKLVAGPNYCYIITFLSLTFCPSSQKFKVPRPVLNFRSTRMRGIHLEIIMKITCSENSPIRKTLITDDLENGPKASVWIHLCNLYKGRNPIKIYDEAYFAEKCKQMLLSVGISDLWGPTIAVHANGKIPKSASLYFNSRGWALHPIADASPTMAKQLWSIGCEIMEVNAILQGSDYSALVDHPDVIYRKIRIDPAKKQYAHSKWNPFKKAISMPNLTDDSI
What is the function of this protein?
The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
What are the official names of this protein?
Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the morbillivirus/respirovirus/rubulavirus M protein family.
What are the subcellular locations of this protein?
Virion.
Protein: NU4C_COFAR
Sequence: MNYFPWLTIIVILPIFAGSLIFFLPHRGNRVIRWYTIFICIFELLLTAYTFCYHFQTDDPLIQLMEDYKWIQLFDFHWRLGIDGLSIGPILLTGFITTLATLAAWPVTRDSRLFNFLMLAMYSAQIGLFSSRDLLLFFIMWELELIPVYLLLSMWGGKKRLYSATKFILYTAGGSIFLLMGVLGIGLYGSNEPTLNFETSANQSYPLPLEIIFYIGFFIAFAVKLPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLVRINMELLSHAHSIFSPWLLIVGTIQIIYAASTSLGQRNLKKRIAYSSVSHMGFIIIGIGSITDTGLNGALLQIISHGFIGAALFFLAGTTYDRIRLVYLDEMGGIAILMPKIFTIFSTFSMASLALPGMSGFVAELIVFFGIITSQKYLLMPKILITFVMAIGMILTPIYSLSMSRQMFYGYKFFNIPNSYFFDSGPRELFLSISLFLPVLGIGMYPDFIFSLSVDKVEVILSNSFSK
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: YBEY_SHIB3
Sequence: MSQVILDLQLACEDNSGLPEESQFQTWLNAVIPQFQEESEVTIRVVDTAESHSLNLTYRGKDKPTNVLSFPFEVPPGMEMSLLGDLVICRQVVEKEAQEQGKPLEAHWAHMVVHGSLHLLGYDHIEDDEAEEMEALETKIMLALGYEDPYIAEKE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLUD_BUCBP
Sequence: MQNKLKLIAIVPKISLLKNRLDQVLASLFKKHSRTILKRHILSKDVCVNGRILDQPDAKVLYKDIISINLKFKAKNDYQAENIFLNVIYEDDDILVINKQDNFVVHPGAGNTSGTLLNALLHRDSTFFNIPRAGIVHRLDKDTTGLMVIAKNNLSYMALIDQIKCKKVIREYQAIVYGKVISGGTIVKSIIRNPIKRTTMIVNKCGKRAITHYRILKRFTHHTHLKIILETGRTHQIRTHMLYINFPLVGDKTYGNKFKFYKNISLTLLEQVKKFPRQALHASRLCLYHPVTKHLMEWNSTLPRDMLNLIALLNKNI
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase D, 23S rRNA pseudouridine(1911/1915/1917) synthase, rRNA pseudouridylate synthase D, rRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: RS11_MYCSS
Sequence: MPPKKAAASSAKKGQKTRRREKKNVPHGAAHIKSTFNNTIVSITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENAARKAQEHGVKKVDVFVKGPGSGRETAIRSLQAAGLEVGAIADVTPQPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: CF120_MOUSE
Sequence: MATPWRRALLMILASQVVTLVKCLEDDDVPEEWLLLHVVQGQIGAGNYSYLRLNHEGKIILRMQSLRGDADLYVSDSTPHPSFDDYELQSVTCGQDVVSIPAHFQRPVGIGIYGHPSHHESDFEMRVYYDRTVDQYPFGEAAYFTDPTGASQQQAYAPEEAAQEEESVLWTILISILKLVLEILF
What is the function of this protein?
May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
What are the official names of this protein?
UPF0669 protein C6orf120 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0669 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted by hepatocytes.
Protein: TMCAL_EXIS2
Sequence: MRMTAIISEYNPFHNGHLYQAKIARQETGADLIVAIMSGTFTQRGEPAFTDKWTRAQAAVASGEIDLVLELPFYFAVQRADRFALGGVTIAETIGAESLSFGSECGQLEPFIEAAAENQEATPRYQELMQEGLARGLSSATAASHAFREMTTTLDLTTPNNTLGYYYARAASTITLHTTKRIGSGYHDLSTGDIMSATAIRAYHATHHSLIGLPELTAETLRNAVFASFEPYYPFIRHRLLTTPLDDLMQFNGIDSSLAPRLIEGARKNETFDNFMTAVKTRRYTRTSLQRVLIYLLTSSKSSEFENIAFDRIDYVRPLAFNDNGRLALREIKQRIPVISTFEKHPWLIKESHVTAAYAVPLARYDRLEEHRRFAHFAGSVSK
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TEX46_HUMAN
Sequence: MSLHGILASAGTIGAVAAWLMSYKPALFGFLFLLLLLSNWLVKYEHKLTLPEPQQDEILQRLLFSEMKMKVLENQMFIIWNKMNHHGRSSRHRNFPMKKHRMRRHESICPTLSDCTSSSPS
What are the official names of this protein?
Testis-expressed protein 46.
Protein: Y650_GEOSL
Sequence: MPVGEGSHHNKILGVRGEDLAAAYLERLRYRIIDRNFRCRGGEVDIVARDGKTLVFVEVKTRRTAGYGVPQLAVTPFKQRQISKAALAWLTRKGMLDVNARFDVIAITILSPDAPRIEHITNAFELAY
What are the official names of this protein?
UPF0102 protein GSU0650.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RL31_CANGA
Sequence: MAGLKDVVTREYTINMHKRLHGVSFKKRAPKAVKEIKKFAKLHMGTEDVRLAPELNQEIWKRGVKGVAFRLRLRISRKRNEEENAKNPLFSYVEPVFVASAKGLQTTVVEEDA
What are the official names of this protein?
60S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL31 family.
Protein: DUT_VACCW
Sequence: MFNMNINSPVRFVKETNRAKSPTRQSPYAAGYDLYSAYDYTIPPGERQLIKTDISMSMPKFCYGRIAPRSGLSLKGIDIGGGVIDEDYRGNIGVILINNGKCTFNVNTGDRIAQLIYQRIYYPELEEVQSLDSTNRGDQGFGSTGLR
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: FTSW_MYCBO
Sequence: MLTRLLRRGTSDTDGSQTRGAEPVEGQRTGPEEASNPGSARPRTRFGAWLGRPMTSFHLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLVLVPGIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRMERASLREMLIPLVPAAVVALALIVAQPDLGQTVSMGIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQGVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGLLPVTGLQLPLISAGGTSTAATLSLIGIIANAARHEPEAVAALRAGRDDKVNRLLRLPLPEPYLPPRLEAFRDRKRANPQPAQTQPARKTPRTAPGQPARQMGLPPRPGSPRTADPPVRRSVHHGAGQRYAGQRRTRRVRALEGQRYG
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell division.
What are the official names of this protein?
Probable peptidoglycan glycosyltransferase FtsW, PGT, Cell division protein FtsW, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. FtsW subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Protein: ARGC_PROMM
Sequence: MSQVRGSRVAVIGATGYGGLQTIRLLEDHPHLHVTYLGGERSAGRRWSELCPFLPILDDPEVQSPDPDKIAEFADYAVLSLPNGLACQLAPQLLKRNVRVVDLSADFRYRSLEQWKQVYVHEAQNLNRDDVQLCREAVYGLPEWKGPEIAVANLVAAPGCFPTASLLPLLPFLKQGLIENDGLIIDAKTGTSGGGRVAKEQFLLAEASESIMPYGVVGHRHTSEIEQLASEVAGQPIELQFTPHLVPMVRGLLATVYGRLRDPGLTAEDCTTVLKAVYRHHPCIDVLPVGTYPATKWVKYSNKAVLSVQVDNRNSRLVLMSAVDNLIKGQAGQGVQCLNLMAGLPPTTGMSLLTFYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YONI_BACSU
Sequence: MENKVTLSDLVRKNIPVILKGSKHPLTEKELLEELAKKIPELVKNGEYRNGVLRGVLNKLSTQPVDRLGISREGNRVKYYFITDKKTELQNVIRNLISEIKEKELLTVDYLNDSPETIDFIKDVSTHVKDLEGFTR
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YonI.
Protein: TREB_NEUCR
Sequence: MTSQPSSGKGRGRNLSIDEYNVYDDAKTYYTTEDRHHNHRAGARTRTYSQNSLFKQFERLGLQKEPYRRGSHDESTIPQSRRFLIQVEPTLQSLQSQEDTDGNMQITIEDNGPKVLSLRTAASNGYNRFDIRGTYMLSNLLQELYLAKEYGRKQIILDEARLNENPVNRLSRLIKDHFWEGLTRRIDASSIEIAARDPKDWTDDPRPRIYIPRGAPEQHEYYTKVALDRPELRLDVQYLPEKITPEIVRDMNAKPGLLAVDMEEVVDPKTGEKTLRGRPFVVPGGRFNELYGWDSYMESLGLLVNDRVDLAKSMVQNFCFCIKHYGKILNATRSYYLCRSQPPFLTDMTLRVYDKIKHEPGALEFLRQSLLAAIKEYYSVWTAEPRLDPVTGLSRYRPEGLGVPPETEAGHFIHILEPYAKKHNMSFDEFVYAYNHGEIKEPTLDDYFMHDRAVRESGHDTTYRFEGICADLATIDLNSLLFKYETDIARTIRNVFHDKFEVPDDWLATNNPAASKLETSAMWDRRAKRRKLAIDKYLWNEEAGMYFDYNTATRKQCNYESATTFWALWAGVSNPKQAAAMVTKALPKLEAFGGLLSGTKESRGEIGLERPNRQWDYPYGWAPQQILAWTGLYRYGFNEEAERLAYKWLFMITKAFVDFNGVVVEKYDVTRPIDPHRVDAEYGNQGLDFKGVAKEGFGWVNASYVYGLQIVNAHMRRALGTLTPYETFMKAVEENRNKALSELV
What is the function of this protein?
Hydrolyzes intracellular trehalose to glucose.
What are the official names of this protein?
Cytosolic neutral trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHPH_RHOSO
Sequence: MSIDSALNWDGEMTVTRFDRETGAHFVIRLDSTQLGPAAGGTRAAQYSQLADALTDAGKLAGAMTLKMAVSNLPMGGGKSVIALPAPRHSIDPSTWARILRIHAENIDKLSGNYWTGPDVNTNSADMDTLNDTTEFVFGRSLERGGAGSSAFTTAVGVFEAMKATVAHRGLGSLDGLTVLVQGLGAVGGSLASLAAEAGAQLLVADTDTERVAHAVALGHTAVALEDVLSTPCDVFAPCAMGGVITTEVARTLDCSVVAGAANNVIADEAASDILHARGILYAPDFVANAGGAIHLVGREVLGWSESVVHERAVAIGDTLNQVFEISDNDGVTPDEAARTLAGRRAREASTTTATA
What is the function of this protein?
Catalyzes the reversible NAD(+)-dependent oxidative deamination of L-phenylalanine to phenylpyruvate.
What are the official names of this protein?
Phenylalanine dehydrogenase, PheDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: OBG_THEAB
Sequence: MQKADFIDRIVIYVKGGKGGDGSASFRHEKYVPKGGPDGGDGGNGGYVFLKANPNLSTLLSVSEKKKYIAENGENGKGKKMHGRNGKDVVIDVPVGTVVKDFETGEIIADLDKPGMVVCVARGGKGGRGNVHFKSSTMRAPKISERGFEGEERKLVLELKLLADVGLVGYPNVGKSSFISKISNARPKIANYPFTTTIPNLGVVTVNELQFVVADIPGLIKGASKGAGLGNVFLRHVERCSVIAHIVDISGMEGRDPVQDYFDIRNELEHFSSELAQKEEIIIANKIDLISKEELEKRLEKLRKETGKQIFPTSIITGEGIEKIVYKLAEIVKESKKFHTQSEVVNEQIKRPKPLWKELPERFNIEIIKEGNDFIVTGTYVEEWAKRLNLNQKDGYRKFMELLEKNGLEKKLKEAGIKDGDTVWVAQRAFEYKE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBID_GLOVI
Sequence: MSRTGYTLPVFAAAAARAALLHLIEKVPCASVQLDLLGEQAAIPIEQVARLDAETALGVTRSDPGDNLDLTRHTPVWAWVHLEVGTGEVLRLEAGEGLGRTAAGEAAIYRYARQLMEANVAPLVPTGRTATVRFILPEGRALALRTSNAAFGILEGLALLGTSGLSQPLSAADHLESFRAALRERAERERRLVFCIGAGGLQAAGRLGLDQGATVQTGNWIGALLVEAGMLGIESVLLLGYQGKLVKLAAGIFNTSSHVADGRLETIAAGAVAAGADIETVRTVLEAPTADAACALLAAAGWAEKIYAALAERVSGRSVEYVRKYTERTMAVATMLLDRQGRVIARDRAAAEWLAEP
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: Y243_CLOB1
Sequence: MSNIDFLPISKEDLKKRNIDVLDFIIVTGDAYVDHPSFGTAIIGRVLEREGFTVGIIAQPNWNNIEDFKKLGKPKYGFLVNSGNIDSMVNHYTASKKKRHDDFYSPGGKSGYRPDRAVIVYCNKIKEAFKDSPIIIGGIEASLRRFAHYDYWDNSVRRSILEDSSADLLIYGMGEKPIVQVSNLLRYGMKIDSIKNVRGTTYIEKDISSLKDYIEIPSFEEVSTNKKSYAEAYKIQYYEQDSIRGKTLVQKHKERYVVQNPPQPPLSQEEMDEVYALPYARTYHPMYEAEGGIPAIKEVKFSITSHRGCYGSCSFCALTFHQGRVIQNRSQDSILKEANMMTNMKDFKGYIHDVGGPTANFRHRACKVQEKHGTCKNKQCVFPKACKNLIVDHKEYLSLLRKIRKIPNVKKVFIRSGIRFDYLMYDKNDEFFKELCEHHISGQLKVAPEHISDKVLNLMGKPTRNVYDSFVKKYYDINKKIHKNQFLVPYLMSSHPGSDLKAAIELAQYIKKMGYTPEQVQDFYPTPGSLSTTMYYTGINPLTEEKVYIPKDQKEKRMQRALLQFSIHDNYDLVKEALIKAHREDLIGNGPDCLIPYNKPYKKSHKKNNAKNNNNHYNKNNNYNKNKDISKKNKKNSLSKHKKRK
What are the official names of this protein?
UPF0313 protein CLB_0243.
What is the protein family that this protein belongs to?
Belongs to the UPF0313 family.
Protein: GDIR2_HUMAN
Sequence: MTEKAPEPHVEEDDDDELDSKLNYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPGPITMDLTGDLEALKKETIVLKEGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDDDKQDHLSWEWNLSIKKEWTE
What is the function of this protein?
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369).  Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).
What are the official names of this protein?
Rho GDP-dissociation inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta.
What is the protein family that this protein belongs to?
Belongs to the Rho GDI family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TNNC3_DROME
Sequence: MSSVDEDLTPEQIAVLQKAFNSFDHQKTGSIPTEMVADILRLMGQPFDKKILEELIEEVDEDKSGRLEFGEFVQLAAKFIVEEDAEAMQKELREAFRLYDKQGNGFIPTTCLKEILKELDDQLTEQELDIMIEEIDSDGSGTVDFDEFMEMMTGE
What are the official names of this protein?
Troponin C, isoform 3.
What is the protein family that this protein belongs to?
Belongs to the troponin C family.
Protein: AL121_ARATH
Sequence: MYRVFASRALRAKSLCDKSSTSLASLTLSRLNHSIPFATVDAEELSGAHPAEVQSFVQGKWIGSSNHNTLLDPLNGEPFIKVAEVDESGTQPFVDSLSQCPKHGLHNPFKSPERYLLYGDISTKAAHMLALPKVADFFARLIQRVAPKSYQQAAGEVFVTRKFLENFCGDQVRFLARSFAIPGNHLGQQSHGYRWPYGPVTIVTPFNFPLEIPLLQLMGALYMGNKPLLKVDSKVSIVMEQMMRLLHYCGLPAEDVDFINSDGKTMNKILLEANPRMTLFTGSSRVAEKLALDLKGRIRLEDAGFDWKVLGPDVQEVDYVAWQCDQDAYACSGQKCSAQSMLFVHENWSKTPLVSKLKELAERRKLEDLTIGPVLTFTTEAMLEHMENLLQIPGSKLLFGGKELKNHSIPSIYGALEPTAVYVPIEEILKDNKTYELVTKEIFGPFQIVTEYKKDQLPLVLEALERMHAHLTAAVVSNDPIFLQEVIGNSVNGTTYAGLRGRTTGAPQNHWFGPAGDPRGAGIGTPEAIKLVWSCHREVIYDYGPVPQGWELPPST
What is the function of this protein?
Plays a role in the inhibition of programmed cell death by converting the toxic proline catabolism intermediate (s)-1-pyrroline-5-carboxylate (P5C) to glutamate.
What are the official names of this protein?
Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial, AtP5CDH, P5C dehydrogenase, Aldehyde dehydrogenase family 12 member A1, L-glutamate gamma-semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: THIG_SHEB2
Sequence: MLTIADVEFESRLFTGTGKFSNSQVMLEAITASKSQLVTVAMKRIDFKMGLDDLLTPLRQAGVRLLPNTSGARNAKEAVFAAELAREMLGTHWIKLEIHPDPKYLMPDAIETLEAARILCEKGFIVLPYVHADPVLCRRLEEVGCAAVMPLASPIGSNQGLVTESFLKIIIEQARVPVVIDAGIGAPSQAARAMELGADAVLVNTAIASSASPIVMAECFKEAVQCGRRAFEAGLGRVQTGAVHTSPLTGFLNQ
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLX4_EMENI
Sequence: MMQITTDFVVLSSSPETSAIHFPPLPLGNSKITSLRDPSMSLSPSPAASPTASKRSTFFSTPPYSQFKTAHKTTQDASKERTTTTKTDENSASSENGCIRRGQKSQPISQVELQNIGQDNSENKENAPTKPKRARKKQEGSRTGTEKLKNKTISGKVTKTGMSKSRTSVIKPVKSKQGTCERNTGKDGCEKDNLQLELAMARRRDWTPTKNAANPVIDLDDEDDATNRPDGLGTLLSGYEYTGMAIASDRHKVLTNSGPTKRRRIELILTHHKQLVDSRVLPAKPKSLSEDDSVQNSEGEAPICAVSKPSKKPKPKTKRLTTLTARVTAPYDLSANSSDSTVQEILGTAEASTGAKPKSRRTKRKADESPEYKVPRTLFSPEDAVKSLDQQELVFGTCSQLQREDSPDMLRDTQIAVQESEKEFTRGMGRLSHTARYSSVLSRLATQRNLWSAAARDTEGQLADVEVVDLVDSPEASKFIVSSLNNEKGTEDHSFATYSSRSSEVLQAKALAPADAPIDEALPALTSHTVEQLEYEEPKNQPITRSKPPLPYYKGKTDLQLASEVRRYGLKPPKNREKLIELLEKCWVAKHGLDLQEAREELQSKTTAGMTFSTSEPKKVEQEPYPKQAKTATQSKITKARSQFRPNVPELTGKSRETNTTTAVVKEDKQNNPKPKLKERQPNPKRSFIDVEEIQDSEDEFLPSPSAILNEFLVSPPRKGKQSNKDTKQNRQELPTSTIPSSPSPKSSLARDSSLSPTRQTKKSRTIPPVSVKRDLLDLGEQITKAVRAQPRRKQNSNPVTTGTRKRPTWHEKILMYDPIYLEDFTSWLNTEGLALVDEDREVAIGFVRQWCESKGICCCFRVKKTSERF
What is the function of this protein?
Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit slx4.
What is the protein family that this protein belongs to?
Belongs to the SLX4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLMH_AERHH
Sequence: MKIQLIAVGTKMPAWVEHGFEEYRRRFPKDMPFELVEIGAGKRGKNADIPRILQKEGEAMLAAAGRSRIVTLDIPGKPWTTEQLAVQLEAWKLDGRDVALLVGGPEGLSPECKAAAEQSWSLSPLTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNDH2_DANRE
Sequence: MDSVETRYAHLLQPLRDLTKNWDIDLASQLGEYLEELDQMTISFDGGKTMMNFAEAALLIQGSTCIYGRKVELLHTLVFQTLDYISNKNKKRDKQGSSSDGNQEQAPSGSEGDGCEFDEIEQDENVNTHNITMKDPTEPVRIIRLPPESLIPAESHEKQKYPLLSLKGELLGSCKDFRINTFTMDEAGLMRLGSNTHFLKGVAEVQRDFSVHLPEPLQIEGEAAAANGGYDEEVDGGAEVLPPLEDHGMEVESDEWVERHEAPSEGRMLRPRPAVQPVSEEPKQLKETVDPWKLHDPYATFGEDKPLKAGKCYKVPAGLDESGKRKRKGPSKLQDFGTWFNKAFETADRKLKNGPTFPDLNYIFVSKMDQRLKVQRQMLRKRGVFVSDEELKKTYLEPENVEDQVEVIRHPDADGDDYSDEEHDNLADDLEPAEHLDDQEQIFQDLHMSRMSYEDLVKKSVDLFLVNSQKYAQETALSRRVKDWEDSINPHLAAQEISPAFDIHEYGDRIVHALSNVGVKKSFAFVVRGKENTEACRYMLAALQLANDYTVEVDKVDGLDCSVDTMELTLLTTQRAHERLKTYNATAATDIP
What is the function of this protein?
Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture.
What are the official names of this protein?
Condensin-2 complex subunit H2, Non-SMC condensin II complex subunit H2.
What is the protein family that this protein belongs to?
Belongs to the CND2 H2 (condensin-2 subunit 2) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COX3_CANLU
Sequence: MTHQTHAYHMVNPSPWPLTGALSALLMTSGLIMWFHYNSMSLLTLGFTTNLLTMYQWWRDVIREGTFQGHHTPIVQKGLRYGMVLFIVSEVFFFAGFFWAFYHSSLAPTPELGGCWPPTGIIPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRKHMLQALFITISLGVYFTLLQASEYYETSFTISDGVYGSTFFMATGFHGLHVIIGSTFLIVCFLRQLYYHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LEUC_THEP3
Sequence: MGLTLTQKILSAKVGREVKPGELIEVDVDMVLGNDVTAPVAIKEFEKIGIDRVFDNTKIALVPDHFVPNKDIKSAEQVNIMRKFAKKHGIVNFFEVGQMGIEHALLPEKGLVLPGDVVIGADSHTCTYGALTCFSTGVGSTDMAAAMATGKAWFKVPEAIKFVLKGNLQKWVSGKDVILYIIGKIGVDGALYKSMEFTGNIKALSMDDRFTIANMAIEAGAKNGIFDFDEITEAYVKGRAKREYKVFERDVDAEYSEVYEISLDEIRPQVAFPHLPENTRNIDEVGKVKIDQVVIGSCTNGRISDMEIAYKILKGKKVHPDVRLLIFPATQEIYLECVKRGYIEEFIKAGAAVSTPTCGPCLGGHMGILAKGERALATTNRNFVGRMGHPESEVYLSSPAVAAASAIAGYIVSPEEV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: RIMO_METFK
Sequence: MSLQSPKVGFVSLGCPKASSDSERILTQLRAEGYAISGSYDDADLVVVNTCGFIDSAVEESLDAIGEALAENGKVIVTGCLGAKSDVVKAAHPGVLAVTGPHALEEVMTAVHANLPKLHDPYTDLVPPQGIRLTPQHYAYLKISEGCNHRCSFCIIPSMRGDLVSRSIGDVMTEAENLVNAGVAELLVISQDTSAYGVDVKYRTGFWNGRPVKTRMTELARALGSLGVWVRMHYVYPYPHVDEIIPLMADGLILPYLDVPLQHASPRILKAMKRPASSENNLARINAWREICPDITIRSTFIVGFPGETDEDFECLLEFLQEAQLDRVGCFAYSAVDGAAANALDNPVPEPLKQERLARFMEVQESISAEKQRRKIGRIETVLIDDIDGDQAIGRTAADAPEIDGVVYLSGADGLQPGDLVEAQIVNSDGHDLWAAPPARD
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.