PharMolix/UniProtQA huggingface dataset:
Protein: NFU1_DROAN
Sequence: MSKLLTNTALSTFRSTRFAARQLSRNFGGIASTAQPVNLKAGYGLDYKKGLLQTQQRQIQLSGARNMFIQTQDTPNPESLKFLPGVEVLGKGNTHDFPSGTTAHGSPLAKLLFRVEGVRAVFFGADFITISKEEGAEWSLIKPEVFAVIMDFFASGLPILHESTPNADTEILEDDDETVMMIKELLDTRIRPTVQEDGGDIVFMGYENGIVKLKMQGSCSSCPSSIVTLKNGVQNMLQFYIPEVESVEQVFDAVDKMADSEFERFERNLKALKEKDSAAPAGGGTN
What is the function of this protein?
Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.
What are the official names of this protein?
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PROF3_RAT
Sequence: MGDWKGYISAVLRDQRIDDVAIVGHSDNRCVWASRPGGLLAAISPQEVGVLTGPDRHTFLQTGLSVAGRRCCVIRDYLLAEGDGVLDARTKGLDGRAICVGHTPRALLVLMGRRGVHGGILNKTVHDLIGGLREQCS
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  Slightly reduces actin polymerization.  Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and phosphatidylinositol 4-phosphate (PtdIns(4)P).  May be involved in spermatogenesis.
What are the official names of this protein?
Profilin-3, Profilin III.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Note=Localizes first in the acroplaxome and later in the manchette during spermatid head development.
Protein: FUMC_NEIMA
Sequence: MNTRTEHDTMGNVEVPSEAYWGAQTQRSRNNFKIGGETLPQPLIYALALVKKAAAATNVSLGRIKPEQADLITQAADDVLNGKLDGQFPLVVWQTGSGTQSNMNMNEVLANRANEIAGTGLAAYQPVHPNDHVNHAQSTNDAFPTAIHVAAAIEINRHLIPAVKALRDTLDKKAQAFAPIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGRLNDALKDLYELALGGTAVGTGLNSHPEYAEKAAAKLAELSGLPFVSAPNKFEALGGRDAAVAASGALKTLAASLNKIANDIRWLASGPRCGLGEIKIPENEPGSSIMPGKVNPTQCEAMTMVCCQVFGNDVTIGMAGASGNFELNVYMPVIAYNLLQSIRLLGDACNSFNEHCAVGIEPVPEKIDYFLHHSLMLVTALNRKIGYENAAKVAKTAYKNNKSLRETAVELGLLTGEEFDELVVPADMVHPR
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_CHLL3
Sequence: MNIISVGVNHKTAPIEIRERISLSEVQNKEFITGLISGGLAHEAMVLSTCNRTELYVVPAMHEVTGEYLKDYIISFRDARKDVRPEHFFSRFYCGTARHLFEVSSAIDSLILGEGQILGQVKEAYRIAAEVQAAGILITRLCHTAFSVAKKVKTKTKIMEGAVSVSYAAVELAQKIFSNLSMKKILLVGAGETGELAAKHMFAKNARNIVITNRTQSKAEALAEELGTNRVLPFESYKEHLHEFDIIITAVSTKDYIITEADMHGAMQKRRLKPVIILDLGLPRNADPEIGKLQNMFLKDIDALKHIIDKNLERRSLELPKVHSIIDEELVAFGQWINTLKVRPTIVDLQSKFIEIKEKELERYRYKVSEEELRRMEHLTDRIMKKILHHPIKMLKAPISTSDNMPSRVDLVRNVFDLEEPNQSH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: OSB11_DICDI
Sequence: MSNFFKKLVKKDGTPKSSRKSKSESPVGKYDMNGNQVVPDTASSYSDDSNSLSDSYDKRGEPNIGEQIDTLDDYNFGNEIGDAESAPEDKKSLWKKVGGLVGKDPMSLVSLPVYFFEPLTVLECQLEPLRFVELIEKASTCSDSIDRLMYLTAFNIAVFSSYTRTAKPFNPLLGETFEYIDKQGRYKSFCEQVSHHPPIGIAQTTSEIFDLQQESWITTKFWGNSLDVFSHGQNHLYLNSTGEHFTWKVPSAICHNIIFGKMWIEHYGDLIVENHNTGEKAIINFQKSGWFEGTQRKVQGEILDSKGNARVHINGKWDKYVKAKKHSEGPSRKSSGEITLWEATIEPPENFNKWKHGKWIQGLNEMSKEYQAVLPSTDSRVRMDRIYLEREENKLANKEKNKIEEREREKRKTRESRKEIWKPNYFSKREDSKYGYRWDFNGKYWDERDKRVDSVVDKFKNDPNFDSNKIPEYDDSKLNISVKSVRKFSRDFTNSSTPTQLKRSFSKLKLEEQPQSQSLPPMIKEELSSSTVDHEETFYSESNEAKLESIKEDANSHTYIYSSPTIGHSGR
What are the official names of this protein?
Oxysterol-binding protein 11, OSBPk.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
Protein: SECR_BOVIN
Sequence: HSDGTFTSELSRLRDSARLQRLLQGLV
What is the function of this protein?
Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis.  Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells.  Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content.  Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity).  Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid.  In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation.  Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation.  Also able to stimulate lipolysis in white adipocytes (By similarity).  Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity).  Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity).
What are the official names of this protein?
Secretin.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDUBA_PONPY
Sequence: MPDSWDKDVYPEPPRRTPVLPNPIVYMMKAFDLIVDRPVTLVREFIERQHAKNRYYYYHRQYRRVPDITECKEEDIMCVYEAEMQWRRDYKVDQEIINIMQDRLKACQQREGQNYQQNCIKEVEQFTQVAKAYQDRYQDLGAYYSARKCLAKQRQRMLQERKAAKEAAAATS
What is the function of this protein?
Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I.  Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, Complex I-PDSW, CI-PDSW, NADH-ubiquinone oxidoreductase PDSW subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFB10 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: CL160_CAEBR
Sequence: MSVQAWTIFLAFLLFPVAVCGYECYVTPCTRDVIIVVDGSSSMQTSTYISQEINVITKLTYSWTLDYSKVRLALVGAYFGNEFNGLDYFTDSSLVEKRLQSFRLAAMQYGLFNGDFNTTVRFLDERYVGQRANFGPRTNVQKRIVIFTSHSGEKDIASTKNTLQKFGQLGYSVTLVGIGVSEDVYKNTYYHKFVTIQWFELGSVAQSIIDTITEEGICFLDQGWTTPKQEICTTTPTTTRAPTTTTKKSTGTVKPATTPKPVPPTHAPFPVGDYQDCSCTTQSLYIDIVFVVDVSEGMGLGGLMMVKAEINTLVGQMSLDPEIQKHVQVGLIKYSNESEIVFKPSEYTNEDEFTEDLWTDPRLEDVDEKTDEVNLHLALQQAAKMIGSMRKGVKKVVVIYAASYNDEGDDDARQIAANIRESGYEIITVAFVEPESSSLVMKIGELASPRMNFTSFRDELLVDELEDALCQVNCYCPNGWKQLVLEDRKYGECFFPTKIDASWTATKFECPILSKEHTGNGHLVYVNSALKNTFLNKFYMDHWDPENQEKPNYDIGLSYDKATQKYIWVNGVTNNPYSNWAEGHPNLSKGECVMSKQEAGTTTDFKWNSINCQTDSGRGLCQEAACDSDFYCPPN
What are the official names of this protein?
C-type lectin protein 160.
What are the subcellular locations of this protein?
Secreted.
Protein: SDHD_VIBC3
Sequence: MMTINIEQLTEQYPLVKELIELKEVSWFNPSITRLEEGLSYVGLGSEDIQDASQRLKRFAPYLAKAFPETAKTNGIIESEVVPISEMQSVLEREYDTPIQGRLLLKKDSHLPISGSIKARGGIYEVLTHAEKLAIEAGLLTESDDYSKLLNEEFRDFFKRFSIAVGSTGNLGMSIGIMSAKLGFSVSVHMSADARAWKKNRLRALGVNVIEYAQDYGVAVAQGRKEAENDPTCFFIDDENSQTLFLGYSVAGERLKKQFDEKGIVVDAQHPLFVYLPCGVGGGPGGVAFGLKMAFGDNVHCIFAEPTHSPCMMLGVHTGLHDAISVQDIGIDNITAADGLAVGRASGFVGRAMERLLDGYLTISDERMYRLLGQLNEAENIQLEPSALAGMIGPIVVTKSVEYRARMQFDDTVMGNATHLVWATGGGMVPAEEMDSYLKNR
What are the official names of this protein?
Probable D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: SYH_SULIK
Sequence: MTKFETVRGMKDYIGIDAEKIRYLESTFRDLAIKYGYSEIITPVVEEFKLFALKGGEELRETMYVFKDKADRELSLRPEITPSVARAYIQNLQSSPKPIRLFYFGTVYRYDEPQYGRYREFRQAGIEMIGDSSILADLEVLDLLYNFYDKLNLSNDITIKINNIGIFRKIMDKYNIEDNLQEHILHLIDKNKINEALDILEKNLKNKDIIDFFNKILTKKDTKLEDIESLAELEEVSRLDIKSEFLYLFRLSRILSNLNIKFKIDLGFVRGLAYYTGLIFEVLHPSVQFSIAGGGRYDKLIELYGGLPSPAIGFAIGVERTLLVIKDLKVEEPVNVIVIGMSEDTIPSMFMVSRILRKEEYKVVINTKDQPLSKLLPYYASQGFKVAIIIGKQELEKNMITVRNLITRKQISVPLENIEDAIKQTL
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_RUTMC
Sequence: MNKKNLLSFNQNALNDFFVGLGEKPYRTKQIMQWIYKDHEFDFEKMLNFSKSLRDELSKVVCVELLRVVKQNFILDGVIKWVLALDKNNHIEMIYIPEKNRGTLCISSQVGCGLACTFCSTGMQGFNKNLTTAEIIAQVLIASRYLNSKTKRISNVVFMGMGEPLLNEHAVYNACDLLLDDLAFGLSRRKVTISTSGVVPAMLRMSERTPVSLAVSLHASDDHLRNELVPINQKYSLEELLKACKVYLQAGTQKRHILFEYVMLKGVNDSIEHANKLVKLLKGISAKINLIPFNSFEKTQYQTSSAQTIEKFQNILYHQGIRTMTRRTRGEDIGGACGQLAGKVLDKTKRTYDRRH
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCRK_VIBAL
Sequence: MNQVWVTGDAVVDLIPESETSLLKCPGGAPANVAVAIARLSGKSAFFGRVGDDPFGRFMQSILDQEGVCTEFLIKDPEQRTSTVVVDLDDQGERSFTFMVKPSADQFMSVEDMGNFKQGDWLHVCSISLANEPSRSSTFEAIKRAKAAGGFISFDPNLRDEVWQDQSEIQAVVMKAVAMADVVKFSEEELLFLTDSTSMAQGLQQIAAMNIALVLVTQGAKGVWRVFESQSELITGQVVSPIDTTGAGDAFVGGLLACLSRHADWKNHPVVSSAIQWANGCGALATTQKGAMTALPTQTELLRFIGQ
What are the official names of this protein?
Fructokinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: LIS11_UNCRE
Sequence: MSQILTGRQAEELHKSLIAYLSSINASQSVTTLREELQIGDNFTDAACKKYEGFLEKKWISVVRLQKRILDLESKIASLQAELDSAPTITSRANRDPKSWLPGTSPTHTLGSHRGAITCVAFHPVFSSLASGSEDYSIKIWDWELGELERTLKGHTRTVTGLDFGGQKGRTLLASCSNDLTIKLWDPSNDYANIRTLFGHDHSVSSVRFLIPGGNILISASRDTTLRMWDTSTGFCVKTIHTQGDWVRDVFPSFDGKWLVSGGRDQAATIWEVSSGEARASLLGHENYIECCTFAPPSSYGYLATLAGLKKPPSTNSSAEFVATGARDKTVKLWDSRGSLIKTLIGHNNWVRGLVFHPGGKYLFSVGDDKTIRCWDLSQEGKLVKTLEGAHEHFVSCIQWAPDPANLVQSSVAERPEGNKGTEHGTTGFRCVIATGSADSCVRVFM
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for nuclear migration during vegetative growth as well as development.  Required for retrograde early endosome (EE) transport from the hyphal tip.  Required for localization of dynein to the mitotic spindle poles.  Recruits additional proteins to the dynein complex at SPBs.
What are the official names of this protein?
Nuclear distribution protein PAC1-1, Lissencephaly-1 homolog 1, LIS-1 1, nudF homolog 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.
Protein: GREA_RHOE4
Sequence: MTETQVTWLTQESHDRLKNELDQLIANRPVIAAEINERREEGDLKENGGYHAAREEQGQQEARIRQLQELLNSAKVGEAPTQSGVALPGSVVKVYYDGDESDTETFLIATREEGARDAKLEVYSPNSPLGGALLEAKVGDTREYNLPNGSTMKVTLLSAEPYHS
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: CYSG_SALPK
Sequence: MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLEAGARLTVNALNFIPQFTVWANEGMLTLVEGPFDETLLDSCWLAIAATDDDTVNQRVSDAAESRRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPQHLGQVARYAGQLRARVKKQFATMGERRRFWEKFFVNDRLAQSLANADEKAVNATTERLFSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMQADMPVALVENGTSVKQRVVHGVLTQLGELAQQVESPALIIVGRVVALRDKLNWFSNH
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: KLD8B_HUMAN
Sequence: MSAGGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVEALCLRDGV
What is the function of this protein?
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318).  Required for mitotic integrity and maintenance of chromosomal stability.  Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy.  Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010).
What are the official names of this protein?
Kelch domain-containing protein 8B.
What are the subcellular locations of this protein?
Cytoplasm. Midbody. Note=In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis.
Protein: COQ4_DROYA
Sequence: MMQRCLRLPKPLALRRGLHVAQVNGQAVATEAPEAEPQDAFERQYLKERIEISPFQRVFLGAGSSIAALLDPRRHDMIACLGETTGEDALLTILDTMQASEEGQRIMADKPRIHTSTIDFKYLETLPPDTFGAAYVKFLKDNQVTPDSRMAVRFLEDPKLAYLMTRYRECHDLIHTVLDMPTNMLGEVAVKWVEALNTGLPMCYGGAVFGAVRLRPKQRRAYLKHYLPWALENGKRSKPLMPVYWEKRWEQNIHELRSELGITVLNKA
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial, Coenzyme Q biosynthesis protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: OS9_CANGA
Sequence: MLVVAFASLLGAARAIMMPIDDPTTSDKFQITYANESLWDTLVMKNKTALESGELFDLGPDTKCFLPNMTRLHEQNVQSVNDPEYKQKLIDTLDMGAHIIDASLKNQCLVSQNGFWTYRYCGSGDFTQYHGVAPDPNDKLTYTLGRSSKQIENREFQLLYDDYGYYISEIIESGDICDVTGTPRAIEIQYTCGNVMRPGTLQWTRETKICHYEAQVIVPDLCQLELLSKNQDKKNAVPIICHMSNDVPDKHNIVDIVSNYDVSFVANQVYFLLPMNNSNVDRALLMYTGNATEDGLEMDPFPMEIYKKFIDVMNKMLGLGLLSPPDGKPFDVHDSYQWIGDIVDMHGNYLNRLRLDVDVNMEATLIIDKSINFTGPNNFQWYFRGSDRTKNSKSRFGSLTNDNMMLAGGSIINVDDISKENAQELLEKLVAAGKLSGVIEDNKITQGSPIEASKTKVTKASESTPVSEKNKKAKTVTKTIIRSRDKEEYFKENEKQGEENNAQVPFSAHNNEQHGTISKSERKEENTNQKQLANTQKGDTDTPPQSSQSSANDKLSRSGMGQKEPGVDEIGSELRGNSKKALGSNIDNSSGRSTLNDNSDRIAVENEAREIINSNAYDQSEASVDPNYRNDQQRLNSAKEHTFSQSKEKKSINSEEILETKILNSETLGNNDGVASDVKDEEVVESDRNGVIDDEL
What is the function of this protein?
Lectin involved in the quality control of the secretory pathway.  As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).
What are the official names of this protein?
Protein OS-9 homolog.
What is the protein family that this protein belongs to?
Belongs to the OS-9 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Protein: TM237_CHICK
Sequence: MGKKQVCPPRALPPVPSFCSADDIPLSRPKKRKPKGKTPLDDIVQATVRRQSESSEPLTPEPQDVPPQRKRKKKKVPPDSETSFTQQNTASLFQNGNGVDVPEAEETVVRKQRKRTKKARPAETHSSNELEVEEDDIIEDEHRRSPDQQPVFAAPTGISQPVSKVFVEKNRRFQAADRAELIKTTENINVLLDVKSSWTTRDVALSVHRSFRVIGLFTHGFLAGYAVWNIVVIYILAGNQLTTVSNLLQQYKMLAYPAQSLFYLLLSISTVSAFDRIDLAKASVALRGFLTLDPAALASFLYFTALILSLSQQMTCDRINLYTPPSENGSIWTAGMEEEILQPWIVVNLVVSILVGASWIFLSYRPELDHSEELMFHTEIEEFPQDEREMLKSQ
What is the function of this protein?
Component of the transition zone in primary cilia.  Required for ciliogenesis (By similarity).
What are the official names of this protein?
Transmembrane protein 237.
What is the protein family that this protein belongs to?
Belongs to the TMEM237 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, cilium. Note=Localizes to the transition zone.
Protein: LSPA_ENT38
Sequence: MTKSFCSTGLRWLWLVVVVLIIDLGSKFLILQNFALGDTVPLFPSLNLHYARNYGAAFSFLADSGGWQRWFFAGIALGICLVLTVMMYRAKASQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGNWHFATFNLADSAICFGAAMIVLEGFLPNAAAKKQA
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS16_CERS5
Sequence: MAMKIRLARGGSKKRPHYSIVASDSRMPRDGRFLEKLGTYNPLLAKDSEDRIKMNVERVQYWLSQGAQPTDRVARFLEAAGLKEKAVRNNPKAAVPGKRMAELAKKKAERAAASAE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: YKOE_BACSU
Sequence: MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEPIYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAVFLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLAGLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL
What is the function of this protein?
Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine.  Could also transport other HMP-containing products.  Probably responsible for the translocation of the substrate across the membrane (Probable).
What are the official names of this protein?
Putative HMP/thiamine permease protein YkoE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HSLU_RHOPB
Sequence: MTDFSPREIVSELDRFIVGQHDAKRAVSIALRNRWRRLQLEGSLREEVLPKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEVGYVGRDVEQIIRDLVEVAISQVREKKRKDVEARAQIAAEERVLDALVGANSSATTRDSFRKKLRAGELNDKEIEVETQSTGGGSPMFEIPGMPGAQMGAISLGDIFGKMGGRTKTRRLTVEDSHELLVNEEADKLLDSDQLVQEAINAVENNGIVFLDEIDKICVRDGRSGGEVSREGVQRDLLPLIEGTTVSTKHGAVKTDHILFIASGAFHIAKPSDLLPELQGRLPIRVELSALTRDDMRRILTEPEASLIKQYVALLQTEGVTLEITDEAIDALADVAVAVNSSVENIGARRLQTVMERVLDEISFTAPDRDGETIQVDAAYVQKHVGDLAKNADLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTBD3_CALJA
Sequence: MVDDKEKNMKCLTFFLMLPETVKNRSKKSSKKANTGSSSSNSSKLPPVCYEIITLKTKKKKMAADIFPRKKPANSSSTSVQQYHQQNLSNNNLIPAPNWQGLYPTIRERNAVMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIELKRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEVQCGKVTVQFQCSSDSTNGTGVQGGQIPELIFYA
What is the function of this protein?
Acts as a key regulator of dendritic field orientation during development of sensory cortex.  Also directs dendrites toward active axon terminals when ectopically expressed (By similarity).
What are the official names of this protein?
BTB/POZ domain-containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Translocates from the cytosol to the nucleus in response to neuronal activity.
Protein: Y357_HAEIN
Sequence: MKTIIRYFSFVMGLMLTLPSFAKEKISIMLDWYVNPDHAAIIVAQQKGFFEKNNLEVEIIEPADPALPPKLAAAEKVDLAVSYQPQLYQQVAEGLPLVRVGSLISNPLNSVVVLKKSNLKSLADLKGKKVGYSVSGFEDGLLDTMLHSIGLSNKDVELVNVNWSLSPSLLTGQVDAVIGAFRNFELNQLALEKQEGIAFFPEQYGVPAYDELILVANKNSVTDKKTSAFLTALEQATSYLQAHPNEAWQAFVSYKPNELNTPLNQLAWKDTLPFLANKPRQLDAKRYQQMAEFMQQKGLIPKALALKEYAVEIE
What is the function of this protein?
Probably involved in thiamine biosynthesis.
What are the official names of this protein?
Putative thiamine biosynthesis protein HI_0357.
What is the protein family that this protein belongs to?
Belongs to the NMT1/THI5 family.
Protein: RL27_HIPCM
Sequence: MGKFMKPGKVVMVLAGRYAGRKAVIVKNIDDGTADRPYSHALVAGIDRYPRKVTAPMGKKKIAKRSKIKAFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKSKARREAKVKFEERYKTGKNKWFFQKLRF
What is the function of this protein?
Component of the large ribosomal subunit.
What are the official names of this protein?
60S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL27 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).