PharMolix/UniProtQA huggingface dataset:
Protein: E2AK1_MACFA
Sequence: MQGGNSGVRKREEEGGGEGAVAAPPAIDFPAESSDLKYDESDVPAELQVLKEPLQQPTFPFAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHHNRAITHLMRSAKERVRQDPCEDVSHIQKIRSREVAFEAQTSRYLNEFEEVAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADRAAIELPTLEVLSDQEEDREQYDVKNDESSSSSIVFAEPTPEKGKRFGESDTENQNDKSVKYTTSLVIRDSGELESTLELQENDLAGLSTSSIMEQQLPLRRNSHLDDSFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIAERNKRSRECVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNADWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVILLELFQPFGTEMERAEVLTGLRTGQLPESLSKRCPVQAKYIQHLTRRNSSQRPSAVQLLQSELFQTSGNVNFTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGGVPV
What is the function of this protein?
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions.  Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock.  EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming.  Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity.  This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR.  Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions.  In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties.  It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity).  Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 2-alpha kinase 1, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Hemin-sensitive initiation factor 2-alpha kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNMT_FRG3G
Sequence: MRILDLFSGTHSVPKACAQREGWSCVTVDLADSDYNVDVLEWDYTKDLKPREFDVVWASPPCRYFSKLRESNIGRGGMTKKSVKEDLETKGLPLLRRAMEIIAYLQPKKFIVENPDTGRMKEYITEWPHYVVDYCAYSDWGYRKRTRLWTDIEGFVPKTCAGKESCPNMERNPSSGRWRHVLATDAGGRGRKGTTRRLRYRVPPAIIVELLDLC
What is the function of this protein?
This is probably the methylase that recognizes and modifies 5'-CpG-3'.
What are the official names of this protein?
Probable DNA (cytosine-5)-methyltransferase, Orphan methyltransferase M.Fvi3IP, M.Fvi3IP.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Protein: LSPA_RHOBA
Sequence: MNSAKVNPSGHAPTPAPTASQGAAFPANRYALFFGLAIAGGALDLWSKEAIFRWRGLPGTQDVYWIIEGYFGIETAVNIGAVFGLGAGQGLVFAAISVFAAAAIIAWLFFFKAARSCWLTFALGCITGGIIGNLYDRLGFWWKPGLPDQWQSGVRDWILWQASDQWKWPNFNIADSLLVTGAIMLLVQSFFFPPPPHGEADGNELPGRRAPDEPTEGTKPAAS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SDHF2_ASPTN
Sequence: MSVSRMIPRLVRASASPMAVPTAFRRSFGSSVVCAKDNDGPRGPSTPSTAPEYRQNQTSKPPNQFMPNSTSTMTNDYPKVGEKASPPELLNSVDPNYRPADPYSGKVQHFTGGRQEPGAQKPELGLGEMEGITFKVEPLQRSGEDTTTMRARLLYQSRKRGILESDLLLSTFADVYLAKMNHEQLQEYDRFLDENDWDIYYWATQDAPEEGTPAEDTPTETWQRTGAKSGEWRQTIGAFKAAYRPVPTRWADSEVLRLLREHVRDNSATGFHAAKNKKTGGSGLGRMPNIQVFDS
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 2, mitochondrial, SDH assembly factor 2, SDHAF2.
What is the protein family that this protein belongs to?
Belongs to the SDHAF2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PROA_ACIET
Sequence: MNALNIAEYTHTLGLQAKTASAQMARAPAAIKNKALLALARLLRQNVDALQGDNARDLERARAAGLAEPMVDRLKLTPKVLETCAQGCEQLAAMPDIIGEIQGMKQQPSGIRVGQMRVPIGVFGMIYESRPNVTIEAASLSIKSGNACILRGGSEAIDSNKALARLVAQALAEAGLPEHGVQLVQTTDRAAVGQLIAMPQYVDVIIPRGGKGLIERISAEAKVPVIKHLDGNCHTYVDDPCDIVMAVQVADNAKTQKYSPCNASEGLLVARGVAAQFLPQIGAVYAAKGVEMRGCPEALAILRAVPGVQLAEATEADWSEEYLAPIISVKVVAGVDEAIAHINRYGSHHTDAILTRDHMHAQQFLRDVDSASVMVNASTRFADGFEYGLGAEIGISTDKFHARGPVGIEGLTSLKWVVLGEGEVRT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_STAES
Sequence: MLNREPLTKEEALTIFESSELDTFDLLNEAYTVRKHYYGKKVKLNMILNAKSGICAEDCGYCGQSVKMKEKQRYALVEQDQIKEGAQVATENQIGTYCIVMSGRGPSNREVDHICETVEDIKKIHPQLKICACLGLTKEEQAKKLKAAGVDRYNHNLNTSERYHDEVVTTHTYEDRVNTVEMMKDNNISPCSGVICGMGESNEDIIDMAFALRAIDADSIPINFLHPIKGTKFGGLDLLSPMKCLRIIAMFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNEEDYRMIEDLGFEIDS
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RDRP_PMMVJ
Sequence: MAYTQQATNAALASTLRGNNPLVNDLANRRLYESAVEQCNAHDRRPKVNFLRSISEEQTLIATKAYPEFQITFYNTQNAVHSLAGGLRSLELEYLMMQIPYGSTTYDIGGNFAAHMFKGRDYVHCCMPNMDLRDVMRHNAQKDSIELYLSKLAQKKKVIPPYQKPCFDKYTDDPQSVVCSKPFQHCEGVSHCTDKVYAVALHSLYDIPADEFGAALLRRNVHVCYAAFHFSENLLLEDSYVSLDDIGAFFSREGDMLNFSFVAESTLNYTHSYSNVLKYVCKTYFPASSREVYMKEFLVTRVNTWFCKFSRLDTFVLYRGVYHRGVDKEQFYSAMEDAWHYKKTLAMMNSERILLEDSSSVNYWFPKMKDMVIVPLFDVSLQNEGKRLARKEVMVSKDFVYTVLNHIRTYQSKALTYANVLSFVESIRSRVIINGVTARSEWDVDKALLQSLSMTFFLQTKLAMLKDDLVVQKFQVHSKSLTEYVWDEITAAFHNCFPTIKERLINKKLITVSEKALEIKVPDLYVTFHDRLVKEYKSSVEMPVLDVKKSLEEAEVMYNALSEISILKDSDKFDVDVFSRMCNTLGVDPLVAAKVMVAVVSNESGLTLTFERPTEANVALALQPTITSKEEGSLKIVSSDVGESSIKEVVRKSEISMLGLTGNTVSDEFQRSTEIESLQQFHMVSTETIIRKQMHAMVYTGPLKVQQCKNYLDSLVASLSAAVSNLKKIIKDTAAIDLETKEKFGVYDVCLKKWLVKPLSKGHAWGVVMDSDYKCFVALLTYDGENIVCGETWRRVAVSSESLVYSDMGKIRAIRSVLKDGEPHISSAKVTLVDGVPGCGKTKEILSRVNFDEDLVLVPGKQAAEMIRRRANSSGLIVATKENVRTVDSFLMNYGRGPCQYKRLFLDEGLMLHPGCVNFLVGMSLCSEAFVYGDTQQIPYINRVATFPYPKHLSQLEVDAVETRRTTLRCPADITFFLNQKYEGQVMCTSSVTRSVSHEVIQGAAVMNPVSKPLKGKVITFTQSDKSLLLSRGYEDVHTVHEVQGETFEDVSLVRLTPTPVGIISKQSPHLLVSLSRHTRSIKYYTVVLDAVVSVLRDLECVSSYLLDMYKVDVSTQYQLQIESVYKGVNLFVAAPKTGDVSDMQYYYDKCLPGNSTILNEYDAVTMQIRENSLNVKDCVLDMSKSVPLPRESETTLKPVIRTAAEKPRKPGLLENLVAMIKRNFNSPELVGVVDIEDTASLVVDKFFDAYLIKEKKKPKNIPLLSRASLERWIEKQEKSTIGQLADFDFIDLPAVDQYRHMIKQQPKQRLDLSIQTEYPALQTIVYHSKKINALFGPVFSELTRQLLETIDSSRFMFYTRKTPTQIEEFFSDLDSNVPMDILELDISKYDKSQNEFHCAVEYEIWKRLGLDDFLAEVWKHGHRKTTLKDYTAGIKTCLWYQRKSGDVTTFIGNTIIIAACLSSMLPMERLIKGAFCGDDSILYFPKGTDFPDIQQGANLLWNFEAKLFRKRYGYFCGRYIIHHDRGCIVYYDPLKLISKLGAKHIKNREHLEEFRTSLCDVAGSLNNCAYYTHLDDAVGEVIKTAPPGSFVYRALVKYLCDKRLFQTLFLE
What is the function of this protein?
Is a methyltransferase active in RNA capping and an RNA helicase.  Methyltransferase displays a cytoplasmic capping enzyme activity.  This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus.  Helicase region probably exhibits NTPase and RNA unwinding activities (Potential).  It also acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  May mediate silencing suppression through either inhibition of HEN1-mediated siRNA or siRNA demethylation (By similarity).
What are the official names of this protein?
Replicase large subunit, 183 kDa protein, RNA-directed RNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: DTX7_ARATH
Sequence: METDFSLVRKEEEEEEDNRNGMSYLSMEMMKKVSSMAAPMVAVSVSQFLLQVISMVMAGHLDELSLSAVAIATSLTNVTGFSLIVGFAGALDTLCGQAFGAEQFGKIGAYTYSSMLCLLVFCFSISIVWFFMDKLLEIFHQDPLISQLACRYSIWLIPALFGFTLLQPMTRYFQSQGITLPLFVSSLGALCFHIPFCWLLVYKLKFGIVGAALSIGFSYWLNVFLLWIFMRYSALHREMKNLGLQELISSMKQFIALAIPSAMMICLEWWSFEILLLMSGLLPNSKLETSVISICLTTSAVHFVLVNAIGASASTHVSNELGAGNHRAARAAVNSAIFLGGVGALITTITLYSYRKSWGYVFSNEREVVRYATQITPILCLSIFVNSFLAVLSGVARGSGWQRIGGYASLGSYYLVGIPLGWFLCFVMKLRGKGLWIGILIASTIQLIVFALVTFFTNWEQEATKARDRVFEMTPQVKGNQKTQIIVEEDTQVLLNHIAETV
What are the official names of this protein?
Protein DETOXIFICATION 7, AtDTX7, Multidrug and toxic compound extrusion protein 7, MATE protein 7.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: APT2_RHIEC
Sequence: MIVAVPNSGASRINQSGVEALREFPNFPIGGILFKDIAPMLAGRGALGEVVSTVASQVSGTEIDAILAVDARGFILGASLADRLGCGFIMVRKPGKLPGDVLSFEYSCEYCSGTLEVTAGLIGDGLRCLIADDLLATGGTARATGNFVKSQGGEIAGYAFILEIEVLKGRRQLDDAPVISAMTC
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase 2, APRT 2.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U76C1_ARATH
Sequence: MEKRNERQVILFPLPLQGCINPMLQLAKILYSRGFSITIIHTRFNAPKSSDHPLFTFLQIRDGLSESQTQSRDLLLQLTLLNNNCQIPFRECLAKLIKPSSDSGTEDRKISCVIDDSGWVFTQSVAESFNLPRFVLCAYKFSFFLGHFLVPQIRREGFLPVPDSEADDLVPEFPPLRKKDLSRIMGTSAQSKPLDAYLLKILDATKPASGIIVMSCKELDHDSLAESNKVFSIPIFPIGPFHIHDVPASSSSLLEPDQSCIPWLDMRETRSVVYVSLGSIASLNESDFLEIACGLRNTNQSFLWVVRPGSVHGRDWIESLPSGFMESLDGKGKIVRWAPQLDVLAHRATGGFLTHNGWNSTLESICEGVPMICLPCKWDQFVNARFISEVWRVGIHLEGRIERREIERAVIRLMVESKGEEIRGRIKVLRDEVRRSVKQGGSSYRSLDELVDRISIIIEPLVPT
What is the function of this protein?
Involved in the N-glucosylation of cytokinins.  Catalyzes the formation of both the 7-N and the 9-N-glucosides.
What are the official names of this protein?
UDP-glycosyltransferase 76C1, Cytokinin-N-glucosyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: GERL1_DICDI
Sequence: MINNFKGILIIILSFLFLLLFKYSNADDYFPYPFFNDQSNQVILFTEINFQGEKFIYNTSMGYLELPNKFHNNVGSFISGTINVCFIKWDPFEQHQIYSRRVNKDYFSNNRFGSRIDGIYNGLCRDSIWK
What are the official names of this protein?
Uncharacterized gerABC family protein DDB_G0278001.
What is the protein family that this protein belongs to?
Belongs to the Dictyostelium gerABC family.
What are the subcellular locations of this protein?
Secreted.
Protein: YBHR_SHIFL
Sequence: MFHRLWTLIRKELQSLLREPQTRAILILPVLIQVILFPFAATLEVTNATIAIYDEDNGEHSVELTQRFARASAFTHVLLLKSPQEIRPTIDTQKALLLVRFPADFSRKLDTFQTAPLQLILDGRNSNSAQIAANYLQQIVKNYQQELLEGKPKPNNSELVVRNWYNPNLDYKWFVVPSLIAMITTIGVMIVTSLSVAREREQGTLDQLLVSPLTTWQIFIGKAVPALIVATFQATIVLAIGIWAYQIPFAGSLALFYFTMVIYGLSLVGFGLLISSLCSTQQQAFIGVFVFMMPAILLSGYVSPVENMPVWLQNLTWINPIRHFTDITKQIYLKDASLDIVWNSLWPLLVITATTGSAAYAMFRRKVM
What is the function of this protein?
Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone.  Probably involved in the translocation of the substrate across the membrane.
What are the official names of this protein?
Probable multidrug ABC transporter permease YbhR.
What is the protein family that this protein belongs to?
Belongs to the ABC-2 integral membrane protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDPA_SHESR
Sequence: MSINIEQAIIHEISQDSQGQLRCRLRPQPLLNSQAVEMMLEELHQTYTSKSGKGFGYFGIHGDDGEANPAFSNALQEYRAGDLGFVEFTGQASKLLQEELAKYDFSQGGFLLMSCYTSMASDFLFVALLSAKSSMTVLDDMELSQNNHLDLSNIQLAARIDLTEWQADKDSRKYISFIRGRAGRKVADFFLDFMGCVEGVNTKAQNKTLMNAVEDFVASSDLTKEERQQCRNKVFEYCSERFDEGADIEIKDLADELADQGMESFYDFARGGCYELDEEFPADKSTLRQLKKFSGTGGGVTISFDGGHLGQRVIYDPISDTLLIKGVPANLKDQLDRRLKGE
What are the official names of this protein?
Nucleoid-associated protein Shewmr7_2293.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RPIA_COXBN
Sequence: MSKNELKKAAAMEAIQFVKNVNIVGVGTGSTVNYFIDALAEIKHQIEGAVASSVATENRLKEHRIPVVDLNSVSNVDVYVDGADEFNKHFYLTKGGGGALTREKIIAAAAKRFICIVDESKQVDVLGQFPLPIEVIPMARSFVAREIVKLKGDPVYRQGFTTDNGNVILDIHNLTILNPVELEAILNNIPGVIANGLFAQQPADDLLIGTPAGVQLHHRK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: IHH_DANAT
Sequence: VMNLWPGVRLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYAMLARLAVEAGF
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.
What are the official names of this protein?
Indian hedgehog protein, IHH.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Cell membrane. Secreted, extracellular space. Note=Indian hedgehog protein N- product: Cell membrane; Lipid-anchor; Extracellular side. The N- terminal peptide remains associated with the cell surface. Indian hedgehog protein C-product: Secreted, extracellular space. The C- terminal peptide diffuses from the cell.
Protein: BOS1_YEAST
Sequence: MNALYNHAVKQKNQLQQELARFEKNSVTAPISLQGSISATLVSLEKTVKQYAEHLNRYKEDTNAEEIDPKFANRLATLTQDLHDFTAKFKDLKQSYNENNSRTQLFGSGASHVMDSDNPFSTSETIMNKRNVGGASANGKEGSSNGGGLPLYQGLQKEQSVFERGNAQLDYILEMGQQSFENIVEQNKILSKVQDRMSNGLRTLGVSEQTITSINKRVFKDKLVFWIALILLIIGIYYVLKWLR
What is the function of this protein?
SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.
What are the official names of this protein?
Protein transport protein BOS1, Bet one suppressor 1.
What is the protein family that this protein belongs to?
Belongs to the BOS1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Protein: NQOR_ARCFU
Sequence: MARILVIFHSITGNTMKLAKAVADGAREGGAEVAVKRVPETIPAEILEKNPGYVKVREELESFEVARPEELQDYDAIIFGSPTRFGVMSSQMKQFIDMTGRLWMERRLEGKVGAVFTSNEMPHGGKEATLLSMLLPLFAHGMIIVGLPPAKELYRAGSYYGAASTGVPKEDDLQVAKMLGKRVAEVAEKLC
What is the function of this protein?
It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing.  It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide.  It prefers NADH over NADPH.
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: RS4_DESOH
Sequence: MGRYRESVCRLCRRENLKLFLKGDRCFSDKCAFDRRGYPPGEHGQLRPKFSGYGIQLREKQKVKRMYGLSEGQFRRVFAEADRRKGITGSTLLVLLESRLDNAVYRLGFVNSRTQGRQLIRHNHFLVNGKNVDIPSYVLSPGDVIEVREKSRNMQVIDESLAAVERRGVPQWLSLEKENKRGVVKNLPVREDITIPIQEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: ACP_HISS2
Sequence: MSIEERVKKIIVEQLGVKEDDVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYVQNNQ
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PORTL_BPB03
Sequence: MARKRNSYKSINDIQRMRGNRWYYHYYQYLCSLAYQLFEWERLPPSVDPSYLEKSIHQFGYVGFYKDPRIGYIACQGALSGTVDHYNLPDRFHASSVGYQNTFKLYNYSDMKEKNMGVAIYNNDLKCSTLPALEMFAQDLAELKEIIAVNQNAQKTPVLIAANDNNQLSLKNIYNQYEGNAPVIFVHESLDLDNLKVFKTDAPYVVDKLNAQKNAVWNEVMTYLGIKNANLEKKERMVTSEVDSNDEQIESSGNIYLKARQEACNKISELYGLNLKVKFRYDIVEQMRLNAQGIENVSRGTLGGETNG
What is the function of this protein?
Forms the portal vertex of the capsid.  This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection.  The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel.  Binds to the packaging RNA (pRNA) and ATPase gp16 motor.
What are the official names of this protein?
Portal protein, Gene product 10, gp10, Head-to-tail connector, Upper collar protein.
What are the subcellular locations of this protein?
Virion.
Protein: SECB_KLEP7
Sequence: MSEQNSTEMTFQIQRIYTKDISFEAPNAPQVFQKDWQPEVKLDLDTASTQLAEGVYEVVLRVTVTAALGEETAFLCEVQQGGIFSIDGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGAEQHQDA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PENT_ANTYA
Sequence: DILRG
What is the function of this protein?
Suppresses growth in rat hepatoma cells and maintains diapause in insects.
What are the official names of this protein?
Yamamarin, Growth-suppressing pentapeptide.
Protein: RAB34_HUMAN
Sequence: MNILAPVRRDRVLAELPQCLRKEAALHGHKDFHPRVTCACQEHRTGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGIPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLADALKENDPSSVLLFLVGSKKDLSTPAQYALMEKDALQVAQEMKAEYWAVSSLTGENVREFFFRVAALTFEANVLAELEKSGARRIGDVVRINSDDSNLYLTASKKKPTCCP
What is the function of this protein?
Transport protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:27113757).  Plays a role in the maturation of phagosomes that engulf pathogens, such as S. aureus and M. tuberculosis (PubMed:21255211).  Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211).  Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity).
What are the official names of this protein?
Ras-related protein Rab-34, Ras-related protein Rab-39, Ras-related protein Rah.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
Protein: PSA_THEAC
Sequence: MQQGQMAYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGVLLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADARVLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQYGGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIGSGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEELKAPEIASITVGNKYRIYDQEEVKKFL
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.  The T. acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg.  Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin-like activities.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PsmA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPOM_NEUCS
Sequence: MIKFYFTTFHMKFPARLFSTSGNRANFEENSSNEVQNQIKYLKDFKKENPKFNWESTTEPKHMILSNIGEYEKNDFNLKSLLNINEFNINVELLRQLFMKLDKNFTYALGVILRNVDSNTNISVDRHFLVNFNTDPVIILQQIYDRIIFLSEKYYLVPVDKLFIKLRKLNFKVKNPVFHPIAKEKTNIHTTIPKGKSKLSRAEFVPHTMDLKFYGVETKHDKEKNIRIFDNGKVILKVKIIKDGVYHLIDVISRDNRLLYQFEDVKHGDGLKRYWINDNMYYYYYDNTLVNVETPQKVGNIEPAKRDKTQDKKILAFDIETFQVPTGNGDSTMIAYACGFYDGKKSLTYYISDFISQREMLLACIKDMLKYDKHTVYCHNFSKFDINFIIKILVQEFVVEKIISKDLDILSIKISYKFEPKKKGGKAERHTITIADSCRLLPGSLDKLAKDHNIITKKGKFPYKFVNKDNLEYVGLLPDYEYYIDPKKGEMITLFEWAAMYTNKWSMRKETIIYLEKDIKALYQLMMEMSNNTYSTFRINITRVKTASALAFLVYRTIFLPNEVEEENETNSPNNILSLFDKKEEKKLTPKYFLPKLKGRLERAVRAAYFGGRNEIFIPIINNIFSFDFNSLYPTAMMMPMPVGIPVHTFCKNLNEIFGFVRAKIITPAINIPVLPCRVKVNGVQKLIFPIGEWTGWYFSEELKLAVEYGYKIEVLESYVFEKRDDPFKEYIEHFASIKDNTKGSKKQMAKLLLNTLYGRTGMNDSAAEIKMLTTNELDNIQLTNNVIHEFEVDDDKHYVRYDKKPCPVLCAQSEKNYELLSYLDGEKDDGFIINSTSIAAATASWSRILMYKHIINSAYTDTDSIFVEKPLDSAFIGEGCGKFKAEYNGQLIKRAIFISGKLYLLDFGGKLEIKCKGITKNKDNTTHNLDINDFEALYNGESRVLFQERWGRSLELGTVTVKYQKYNLISGYDKREKLYSLGKWVNTSPLCINENFEVISKALVSDVGESWYRKRIHYNK
What are the official names of this protein?
Probable DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PYRG_STRT2
Sequence: MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKDKIKRAATTTDSDVVITEVGGTVGDIESLPFLEALRQMKADVGSDNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPAGQGIKNKLAQFCDVAPEAVIESLDVEHIYQVPLNMQAQGMDQIVCDHLKLNAPAADMTEWSAMVDKVLNLKKTTKIALVGKYVELHDAYLSVVEALKHSGLANDTAIDIDWVNANDLTAENVASRLADADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGVCLGMQLTCIEFARHVLHLDGANSAELDPETQYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAAAYGNQEVVQRRHRHRYEFNTKFREQFEAEGFVFSGVSPDNRLMEVVELPDKKFFVAAQYHPEYHSRPNHAEELYSAFVTAAVENAK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.