PharMolix/UniProtQA huggingface dataset:
Protein: UBP26_ORYSJ
Sequence: MSRPNTRNKSKRPRADDCESPSAVFKKIHSTGAITKGDIKQLYMVWKPVCHGCHGNSKDSPNCFCGLIPAANGVRKSGLWQRTNEIIRALGPNPSTDLRDSTETPAGLTNLGATCYANSILQCLYMNTSFRLGIFSLEPDILKMHPVLDQLARLFAQLHSSKMAFIDSAPFIKTLELDNGVQQDSHEFLTLFLSLLEGSLSHSKVPGARTIVQHLFRGSVSHVTRCSSCGRDSEASSKMEDFYELELNIKGLNNLEQSLDDYLSTEALDGENQYFCESCQKRVDATRCIKLRSLPPVVNFQLKRYVFLPKTTTKKKISSAFSFPGQLDMGKRLSNPSSSYTYGLSAILIHKGSAANSGHYVAHVKDESNGQWWEFDDEHVSKLGLHPFGEKPGKSSDKTDQKPQGSSTADSVTNDDNNSCHEAAFTSTMEEMFSSTDAYMLMYKRIAKDENGIESNNISSNNSLPHHFVDEIDERNTSYVKECEEYESKKDVHLAYITERRQEVKSVLTEAPATPEEDSYFWISTDWLRQWADNVNPPSPIITGVRVHSSIDNSPIQCEHGKVPASKVTSMKRLSAGAWHKLFSKYGGGPTLSSDDFCMECLKDGAKNSVSADVYRDRKASLRSIAEAALAGNNPDGPLYFVSRPWLTQWLRRKNVDIPSDADSGPTIALTCTHGNLLPEHASGAKRVTVPEDLWLFLYETSGMKIDDIVTFPSDSQPCGICSQQLSVVASVEDNLRAVKLKQRQSHEKLTSGKSLALHPGQKYYLVPSSWLSEWRAYITATGKNISSLPEPQSLEVTINSLICEKHSRLLQRPLDLVCKRGTITQKASNTDGLTMISESDWILFSEEWNVAHGKGLCAEIVFSKSSQDNLQSSEAVPILVEDLDQSTNDLSNDLGGREPYVRTDPEVCEECIGEKESCALVEKLNYQNEDIQVYLVRGKEAPKSIREASAAVPVPDRRTSKRSRRTTSGNSISLKVSGSTTVYQLKLMIWESLGIVKENQELHKGSVEIEDDFATLADKCIFPGDVLWVKDSEIYENRDIADEISEQKVVVQTEEGFRGTLLTSSASAQLCQDISFSD
What is the function of this protein?
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin.  Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.  Deubiquitinates H2BK143ub1 of histone H2B (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 26, Deubiquitinating enzyme 26, Ubiquitin thioesterase 26, Ubiquitin-specific-processing protease 26.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SELA_HAEI8
Sequence: MTALFQQLPSVDKILKTSQGLQLITEFGHTAVVATCRELLTQARQFIKKNNQLPEYFSNFDRTFVEIHSRLQKQNQVQIKAVHNLTGTVLHTNLGRALWSEAAQQAALSVMQKNVSLEYDLDKGKRSHRDNYISELLCKLTGAEAACIVNNNAAAVLLMLATFAQGKEVIISRGELIEIGGAFRIPDIMEQAGCYLVEVGTTNRTHLKDYRNAITENTAFLMKVHSSNYQICGFTSSVSEEELAELGREMNVPVVTDLGSGALIDLSQYGLPKESTVQEKVAQGVGLVSFSGDKLLGGVQAGIIVGKKEWIEQLQAHPLKRALRCDKVILAGLEATLRLYLNPEKLTEKLPTLYLLTQPLKQLKINAMRLKERLESRLNSQFDIQIEASQAQIGSGSQPMERIPSVAVTIAEKTNVKLSALSARFKQLSQPIIGRMENGKIWLDLRSLAAIETLLNTLDEL
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBP3_YEAS7
Sequence: MTKEEIADKKRKVVDEEVIEKKKSKKHKKDKKDKKEKKDKKHKKHKKEKKGEKEVEVPEKESEKKPEPTSAVASEFYVQSEALTSLPQSDIDEYFKENEIAVEDPLNLALRPLLSFDYLSLDSSIQAEISKFPKPTPIQAVAWPYLLSGKDVVGVAETGSGKTFAFGVPAISHLMNDQKKRGIQVLVISPTRELASQIYDNLIVLTDKVGMQCCCVYGGVPKDEQRIQLKKSQVVVATPGRLLDLLQEGSVDLSQVNYLVLDEADRMLEKGFEEDIKNIIRETDASKRQTLMFTATWPKEVRELASTFMNNPIKVSIGNTDQLTANKRITQIVEVVDPRGKERKLLELLKKYHSGPKKNEKVLIFALYKKEAARVERNLKYNGYNIAAIHGDLSQQQRTQALNEFKSGKSNLLLATDVAARGLDIPNVKTVINLTFPLTVEDYVHRIGRTGRAGQTGTAHTLFTEQEKHLAGGLVNVLNGANQPVPEDLIKFGTHTKKKEHSAYGSFFKDVDLTKKPKKITFD
What is the function of this protein?
ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis.  Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP3, DEAD box protein 3, Helicase CA3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL35_SALG2
Sequence: MPKIKTVRGAAKRFKKTGKGGFKHKHANLRHILTKKATKRKRHLRPKAMVSKGDLGLVIACLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: GRPE_CAUVC
Sequence: MTDEQTPAEEMPFEADDAAQEIEALKLEVAQLKEQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRATAHSPKDSTDPAVKNFIIGVEMTEKELQSAFERNGLKKIDPAKGDKFDPHLHQAVTEQPSTEVAAGGVLMVMQAGYELMGRLVRPAMVAVAAKGSTGPASPDAPAASANPYAGAAAEGDSTGGAFDAKA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_RHOCS
Sequence: MSKVIGIDLGTTNSCVAIMEGTQAKVIENAEGARTTPSMVAFTQGGERLVGQPAKRQAVTNPENTFFAIKRLIGRRYDDPLTQKDKGLVPYRIVGGKNGDAWVESHGKQYSPSEISAFILQKMKETAENYLGEKVTQAVITVPAYFNDSQRQATKDAGKIAGLEVLRIINEPTAAALAYGMEKKGTGTIAVYDLGGGTFDISVLEIGDGVFEVKSTNGDTFLGGEDFDAKIIDYLAEEFQKEQGIDLRKDRLALQRLKEAAEKAKIELSASMQTEVNLPFITADASGPKHLNIKLTRSKLEALVDDLVRRTIEPCKAALKDAGLKASEIDEVILVGGMTRMPKIIETVKQFFGREPHRGVNPDEVVAVGAAIQGGVLKGEVKDVLLLDVTPLSLGIETLGGVFTRLIDRNTTIPTKKSQVFSTAEDNQTAVTIRVFQGEREMAADNKMLGQFDLMGIPSAPRGVPQIEVTFDIDANGIVNVSAKDKATGKEQTIRIQASGGLSDADIDRMVKDAEAHAAEDKKRRELVEARNQADGLIHTTERTLSENGDKLPGAEKSAAEAAIAELRTAMAADDVADIKAKTDALAQASMKLGEALYKAGQETGGPGAPGGDSGASEAGGEKVVDADFEEVDDDRKKSA
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ASAD_ASPFN
Sequence: MGFFIQHGLTKPEILYPFLFGIFAVASLCIATLLFPASFSAASRVISWVLSIYLEVKNPIRHTETGRNIPGPSYVWPNGQGDIEKYVQGRSRSEQWQRKYGNVYRIWAGMTPEVVLTRPEQLHAIFKDSDKHTKATNSDSGYFMSRILGQCLGLMAGPRWKLLKGIAAPPFMHPTAVRSIGRIQEHVRAHFHDLETNGNLREGRIHPVQDLKMLPFFIVAEANYGSLTPAMKSELDSLAPARENLMKFVLFGGLARFNISRFFPTEANRQLRRFRSQWRAFNRAAYERAREKHPSAMVVQMYDAVHKGVLTEEQVAQTMDETLYANLDVTTGGLSWNLVFLAANPACQARLHEEISALTPAEEEGYISRNGTYLAACVLESSRLRPALPFTIPQSAPTERVVDGYRIPAGTNYVVDTWGLNVRDEFWAPDNSTYRPERFLNSSNTDLRYHFWRFGFGPRQCIGRYTADVVIRAILLHLVKHYELQMLEEGDFTQDPECWITHPDLQVKCVRRT
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspergillic acid, a hydroxamic acid-containing pyrazinone with aliphatic side chains that originates from leucine (Leu) and isoleucine (Ile) (PubMed:29674152).  Aspergillic acid has antibiotic properties and was shown to be lethal to mice (PubMed:29674152).  The first step in the pathway is the production of deoxyaspergillic acid via a condensation between the Ile amine and the Leu carboxylic acid, followed by a reductive release from the protein forming the dipeptide aldehyde NH(2)-Leu-Ile-CHO, which could undergo an intermolecular cyclization resulting in a dihydropyrazinone (PubMed:29674152).  As the NRPS asaC lacks a condensation domain, it is improbable that it is responsible for condensation of Leu and Ile (PubMed:29674152).  One possibility is that asaC acts on a previously condensed dipeptide and functions as a Leu-Ile reductase to yield deoxyaspergillic acid (PubMed:29674152).  After asaC forms deoxyaspergillic acid, the cytochrome P450 asaD oxidizes the pyrazinone to the hydroxamic acid-containing bioactive metabolite aspergillic acid (PubMed:29674152).  The hydroxylase/desaturase asaB can then convert aspergillic acid to hydroxyaspergillic acid (PubMed:29674152).  Both aspergillic acid and hydroxyaspergillic acid can form complexes with iron producing ferriaspergillin analogs (PubMed:29674152).
What are the official names of this protein?
Cytochrome P450 monooxygenase asaD, Aspergillic acid biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MT2_CANGA
Sequence: MPEQVNCQYDCHCSNCACENTCNCCAKPACACTNSASNECSCQTCKCQTCKC
What is the function of this protein?
The metallothioneins are involved in the cellular sequestration of toxic metal ions.
What are the official names of this protein?
Metallothionein-2, MT-2, Metallothionein-II, MT-II.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 10 family.
Protein: RL21_STRP6
Sequence: MSTYAIIKTGGKQVKVEVGQAIYVEKIDAEAGAEVTFNEVVLVGGDKTVVGTPVVEGATVVGTVEKQGKQKKVVTFKYKPKKGSHRKQGHRQPYTKVVINAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RLMN_BORPD
Sequence: METAERVNLLGLDGAALSDLVGQWGGKPFRARQLQRWIHQRGADSFDAMTDLARDFRGQLAQQCRIQALPVNTEQRSSDGTRKWLFDVGQGNAIETVFIPEDDRGTLCVSSQAGCAVNCRFCSTGHQGFNRNLTSSEIIGQLWWAKRVLEADAGTARLGGAGNDDTRVVSNVVMMGMGEPLLNYDQLLPALRLMLDDNAYGLSRRRVTVSTSGVVPMMDRLSRDCPVALAVSLHAPTDALRDELVPLNKKYPLAELLAACERYLASAPRDFITFEYCMLDGINDTDQHARALIQVARQVRCKLNLIPFNPFPASGLKRSPSARVKVFAQRLMDAGIVTTVRKTRGDDIDAACGQLAGEVRDRTRVAQRNAGRTIPIAQVQA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FCL_CRIGR
Sequence: MGEPQGSRRILVTGGSGLVGRAIQKVVADGAGLPGEEWVFVSSKDADLTDAAQTQALFQKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHINDNVLHSAFEVGTRKVVSCLSTCIFPDKTTYPIDETMIHNGPPHSSNFGYSYAKRMIDVQNRAYFQQHGCTFTAVIPTNVFGPHDNFNIEDGHVLPGLIHKVHLAKSNGSALTVWGTGKPRRQFIYSLDLARLFIWVLREYNEVEPIILSVGEEDEVSIKEAAEAVVEAMDFCGEVTFDSTKSDGQYKKTASNGKLRAYLPDFRFTPFKQAVKETCAWFTDNYEQARK
What is the function of this protein?
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
What are the official names of this protein?
GDP-L-fucose synthase, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase, Protein FX, Red cell NADP(H)-binding protein.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
Protein: GLPK_STRP7
Sequence: MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAGWVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKKTGLPIYNAIVWQSRQTAPLAEQLKSQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEGAQERAEKGELLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAILPEVRSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYARDSHNNDEVYVVPAFTGLGAPYWNQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDIIDTMQVDTQTTIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGLSVGYWKDLDELKLLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEVDD
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: OSS2_PEA
Sequence: MSLRSAFALLPLFLLLIVANVESRKDVGEYWKLVMKDQDMPEEIQGLLDASNIKNSKTHAKENMGAIGEFEPRPYASAYGDNEIHAKENMGAIGEFEPRPNASAYGDNEIHANENKGASGEFEPRPNISAYGDNEIHANENKGAIGEFETRPNASAYGDNEIGAEFTDDFEPRPSMTKYNA
What are the official names of this protein?
Organ-specific protein S2.
What is the protein family that this protein belongs to?
To organ specific protein P4.
Protein: GIMA6_BOVIN
Sequence: MSSMFVYVWGTVTDLLHSACSVLALNGDTESSGEHTAPGDTRHGHSSCPTDSRAMEEEEFEILLPEEPEEGTSQDPSPDRSGGFLGDEGTLQTLWLILVGKSGSGKSATGNSILGRRVFESKLSARPVTQAFQQGCRAWEGRELQVIDTPDILSPWAAGWATAQGVGEAGTGSLPKQYAVLLVTQLGRFTEEDQQVAGRLEEVFGKGILARTILVFTRKEDLDGRSLETYLRETDNRALAKLDDVCSRRHCGFNNKGDGAEQETQLRELMRHVEGVLKEPEGCAYSPPATPQPHAAPRESWGLWWLGAKEGRGDQAWLWGLHRILKEPEQAGRQLPPSTPI
What are the official names of this protein?
GTPase IMAP family member 6, Immunity-associated nucleotide 6 protein, IAN-6.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ISPE_FRATO
Sequence: MANIKAKKYYSYAKINLFLHILNKRTDGYHNLQTWFTFLDLKDQLTFSFNNSREINISSNISIAAKQDNLVYKAIKKFQQSYRVQDIGVDIEIKKNIPMGAGLGGGSSNAATTLIALRDYYLPQLSNEEMIPLAVKLGADVPIFVYGKSAWAEGIGEILYHKDFSPQYALLIKPDIHISTKEFFTSEDLIKSSVLISKDLGFDKSIMHNDFENVFYAKYPEFSQYLKELDSDFRMTGTGSCFYLLSADKNKLEQLTRKINKPLDKWLVKTLNYVY
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PTH_OCEIH
Sequence: MKLIVGLGNPGRKFKKTRHNIGFFVIDELLQRHKWKLNNSKFEGDYSIEHFDGEKVILLQPQTYMNLSGKSISPLMDYFDIDVDDVIVVYDDLDLPTGKIRLRQKGGHGGHNGVRSTIDHLGTKDFKRVRLGIGRPTNATPVIDYVLGKFPKQETTAVTDSVEKAADAIEAWIKGKPFLEVMNDFNQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_THIDA
Sequence: MKLQLIAVGHKMPDWINAGYADYVRRMPGDLQLALTEIKPGHRVAGADGARARQLEAARILAAITPGAVRVVLDERGTQATTRELAGWLENWMGEGLTPAFVIGGADGLDDSVKAGAGKLFGLSRLTLPHALARVILAEQLYRAACIIKGHPYHRD
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_YERPA
Sequence: MSKSTAEIRQAFLDFFHSKGHQVVSSSTLVPNNDPTLLFTNAGMNQFKDVFLGLDKRAYSRATTSQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKHDAINFAWELLTSEQWFNLPKEKLWVTVYETDDEAYNIWANEVGVPHERIIRIGDNKGGAFASDNFWQMGDTGPCGPCSEIFFDHGDHIWGGPPGSAEEDGDRYIEIWNIVFMQFNRQSDGTMLPLPKPSVDTGMGLERIAAVLQHVNSNYEIDLFRDLIAAVADVTGATDLSSKSLRVIADHIRSCAFLISDGVIPSNENRGYVLRRIIRRAIRHGNMLGAKETFFYKLVAPLIAVMGPAAAELKQQQAMVEQVLKTEEEQFARTLERGLALLDDELSKLTGDTLDGETAFRLYDTYGFPVDLTADVCRERNLKVDEAGFEQAMEAQRRRARESSGFGADYNSLIRVDSASQFSGYDHVQQHATVTALFRNGEAVDEIHAGEEAVVVLNRTPFYGESGGQVGDKGELKNATATFSVTDTQKYGQAIGHVGILTTGTLRVNHSVEALVDVVRRNRIRLNHSATHLLHAALRNVLGEHVAQKGSLVNDKYLRFDFSHFEAMKPEQIRLVEDLVNEQIRRNMPVQTEVMELDAAKEKGAMALFGEKYDDQVRVLTMGDFSTELCGGTHASRTGDIGLFRILTESGSNLPGCTILRNLAIAGFSAFGSRKLSKRASEPSGRKFEPSVARQRCFSNGP
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_BORHD
Sequence: MIVLGIESSCDDCCAAIVEDGVKILSNIKLSQKEHKKYYGVVPEIASRLHTEFIMSVCQKAITNAQIHASEIDLIAVTSKPGLIGSLIVGINFAKGLSIALKKPLICIDHILGHLYAPLMTIKIEYPFLSLILSGGHTILAKQNDFDDIEILGRTLDDACGEAFDKVAKHYKMGFPGGPNIEKLAKCGNQYAFNFPITIFDKKENRYDFSYSGLKTACIHQLEKFKDKNENITNNNIAASFQRVAFENLIIPIKRAIKDTNIKKLIISGGVASNLYLREKIKNLEVETYYPPIDLCTDNGAMIAGIGYLMYLKYGASPIETDANSRIENYKYTKGAKL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGTB2_CAEEL
Sequence: MSFAGLLDFARKDVDLPQNSPNELLKDLHANFINQYEKNKNSYHYIMAEHLRVSGIYWCVNAMDLSKQLERMSTEEIVNYVLGCRNTDGGYGPAPGHDSHLLHTLCAVQTLIIFNSIEKADADTISEYVKGLQQEDGSFCGDLSGEVDTRFTLCSLATCHLLGRLSTLNIDSAVRFLMRCYNTDGGFGTRPGSESHSGQIYCCVGALAIAGRLDEIDRDRTAEWLAFRQCDSGGLNGRPEKLPDVCYSWWVLASLAILGRLNFIDSDAMKKFIYACQDDETGGFADRPGDCADPFHTVFGIAALSLFGDDTLESVDPIFCMTKRCLGDKQVEMYY
What is the function of this protein?
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal.
What are the official names of this protein?
Probable geranylgeranyl transferase type-2 subunit beta, Geranylgeranyl transferase type II subunit beta, GGTase-II-beta, Rab geranyl-geranyltransferase subunit beta, Rab GG transferase beta, Rab GGTase beta, Rab geranylgeranyltransferase subunit beta, Type II protein geranyl-geranyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the protein prenyltransferase subunit beta family.
Protein: ATPB_PROM3
Sequence: MAAAATATAGTKGVVRQVIGPVLDVEFPAGKLPKILNALRIDGKNPSGQHIAITAEVQQLLGDHRVRAVAMSSTDGLVRGMEALDTGSAISVPVGEATLGRIFNVLGEPVDEQGPVTTDATAPIHRPAPKLTELETKPTVFETGIKVIDLLAPYRQGGKVGLFGGAGVGKTVLIQELINNIAKEHGGVSVFGGVGERTREGNDLYEEFKESGVINSDDLSKSKVALCFGQMNEPPGARMRVGLSALTMAEHFRDVNKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTDVGALQERITSTLEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLARALAAKGIYPAVDPLDSTSTMLQPSVVGDEHYRTARSVQATLQRYKELQDIIAILGLDELSEDDRRTVDRARKIEKFLSQPFFVAEIFTGMSGKYVKLEETIAGFNMILAGELDHLPEQAFYLVGNIDEVKAKAEKIASEAKG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: BTRF1_EBVA8
Sequence: MLKCKQPGARFIHGAVHLPSGQIVFHTIHSPTLASALGLPGENVPIPALFRASGLNVRESLPMTNMRAPIISLARLILAPNPYILEGQLTVGMTQDNGIPVLFARPVIEVKSGPESNIKASSQLMIAEDSCLNQIAPFSASEHPAFSMVESVKRVRVDEGANTRRTIRDILEIPVTVLSSLQLSPTKSILKKAPEPPPPEPQATFDAAPYARIFYDIGRQVPKLGNAPAAQVSNVLIANRSHNSLRLVPNPDLLPLQHLYLKHVVLKSLNLENIVQDFEAIFTSPSDTISEAETKAFEKLVEQAKNTVENIVFCLNSICSTSTLPDVVPDVNNPNISLALEKYFLMFPPSGTIMRNVRFATPIVRLLCQGAELGTMAQFLGKYIKVKKETGMYTLVKLYYLLRI
What are the official names of this protein?
Uncharacterized protein BTRF1.
What is the protein family that this protein belongs to?
Belongs to the lymphocryptovirus BTRF1 family.
Protein: PUR9_CRYNH
Sequence: MSSEAPIALLSVYDKTGLLPFAKSLKELGFRLLGSGGTAKMIREAGMEIEDVSNITKAPEMLGGRVKTLHPAVHGGILSRDIPSDLADLATNKISPITLVVCNLYPFVLQTAKPDCTLAGAIEEIDIGGVTLLRAAAKNHGRVSIISSPSDYETIVAELRAKGEVSAETRRGLAIKAFEDTKSYDEAISDYFRKVYATPGVEEEMKAGAGVGYQRLGLRYGANPHQKPAQAFVEQGEMPIKVLSGSPGYINLLDALNSWALVKELAAGLDLPAAASFKHVSPAGAAVGLPLDERAAKVFGVEDLKELSPLACAYARARGADRMSSFGDFIALSHTVDTPTAKIISREVSDGVIAPGYEPEALEILSKKKGGKYCVLQMDPTYVPPEIETRQVYGISLQQKRNDCKIDESLFKNVVTANKDLPKSAVTDLVVATLALKYTQSNSVCYALNGTVIGLGAGQQSRIHCTRLAGDKADNWWLRHHPRVLELPFKKGTKRADKANAIDLFVTGQAFEAEGGERAQWESLFETVPEPLTKEEREKHMKELTGVACASDAFFPFPDNVHRAKRSGATYLAAPSGSIMDKECIKAADESNLVFCHTDLRLFHH
What is the function of this protein?
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:36063996).  Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:36063996).  Also catalyzes the cyclization of FAICAR to IMP (PubMed:36063996).
What are the official names of this protein?
Bifunctional purine biosynthesis protein ADE16.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: LEUD_PSEF5
Sequence: MKAFTQHNGLVAPLDRANVDTDQIIPKQFLKSIKRTGFGPNLFDEWRYLDVGQPYQDNSKRPLNKDFVLNAERYQGASVLLARENFGCGSSREHAPWALEEYGFRSIIAPSYADIFFNNSFKNGLLPIILSDAEVDELFQQVEATPGYQLRIDLQAQTVTRPDGKVLKFEIDAFRKHCLLNGLDDIGLTLQDGDAIAAFEAKHRASQPWLFRDA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: GP182_RAT
Sequence: MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELNENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRLRRQGQTESRRHCLLMWAYIVVFVICWLPYHVTMLLLTLHTTHIFLHCNLVNFLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPLQRICTPTPSETCRPPLCLRTPHLHSAIP
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
G-protein coupled receptor 182, G10D, NOW.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.