Protein: ILIA_HYPJQ
Sequence: MDQQRQQDGRFREPIAVIGSACRFPGACSSPSKLWDLLQQPRDVLKEFHPERLNLSRFHHKSGDTHGATDVGNKSYLLEEDTRLFDAAFFGISPIEAAGMDPQQRILLEAVYETFESAGVTLDELRGSFTSVHVGCMTSDWANIQARDTETVPKYNATGSANSILSNRISYIFDLKGPSETIDTACSSSLVALHNAARGLLNGDCNAAVVAGVNLILDPAPFINESKLHMLSPDARSRMWDKDANGYARGEGAGALLLKTLSQALKDGDHIEGLVRATGVNSDGQSPGITMPYSPTQTALIQQTYARAGLDPIKDRPQYIECHGTGTPAGDPVEARALSNAFIGHVDKSTENPILVGSIKTVIGHLEGGAGIAGVIKVLLSIKYRVIPPNLLFKDLNPDIAPYYGPLQIPTTAVPWPELPPGTPARASVNSFGFGGTNAHAVIESFDESFGPRASSADEGVVGPLLFSAKSGASLLRSVRDNLEYLQKDASLDLRDLSAFLQSRRTTHRVRAHFTGSSRDAVLENMTNFITTHAQSASDQIGHQPQLINPKEVPGVLGVFTGQGAQWPAMGRELYCKSALFRKTIEECEAVLDALPQQDRPDWSLTEELMKDAISSRISEAALSQPLCSAVQLALVKLLQAAGIAFDAVVGHSSGEIAATFAAGIITLQGAMQIAYYRGLHAKSAGGANHAKGAMMAVGLSFAEAKQFCSRPEFDGKIKVAASNAPKSVTISGDVDAIVQAHEILQADNIFARRLQVDTAYHSHHMLPCCQPYLNSLLACNIKVMQPTGKCTWISSVRGDTQLLRGDLSSLKGQYWVDNMVRTVLFTQAIESSIWHGGPFDLAIEVGPHPALKGPTEQTLKASYGILPVYTGVLKRGENNVEAFSAAVGTTWAQLGPAFVDFAGYRNLFYEAETPVFKIPKGLPLYSWDHDKVFWREGRLSRRFRLGNDQGHELLGRRTLDDNDTELRWRNVLKLGEMPWLRGHEVLGEVLLPGASYVSVAVQAGHNIAMTMGKNVRLIEISNVDILRPVVVPEGTDGVETLFTTRIVETTRDHIKAEFMYYVCPDESLGTMLRTCNGEVMVYLETQTDIASPDTLPAKDAMPLNLTKIDTERVYSLFKDIGLNYSGLFRGISTIERKLDYASTRSTWVDGLDSAYVVHPAMLDVAFQTMFIAKAHPASRQINSALLPSHIDRVRINPSVQFTQPNEVAETAAEFETWAVKQTANSLVGDLNIYDAATGKTFLQVEGLAVNSVGEQDASSDNSMFSRTLWGQDVTLGLPDPVRDPVKDAEGLQMAHAVERVAVFYVKNILKEVKKEERADFQWYHQRMFEAFENHISIVKNGEHPIILPEWLDDEESILDELDSKHGDTIDFKLLHAVGKDLAHVVRGNKQMLEVMTKNDMLNRFYMEGYASVPTNKAVGDVMRQLSFKFPRAKILEIGAGTGGTSWSVLKSINDAYESYTYTDVSSGFFHLAEEKFSDFAHKIIFKVLDIEQEPKEQGFKEQSYDIIIAALVLHATHDLERTMRHARSLLKPGGFLVMVELTGTMSVRATLVMGGLPGWWLGENDGRRLSPLVTAIEWDRLLQNTGFSGADAVIHDLADEEKHCTALIMGQAVDDDFQRLRSPLSTVAELPPPDDPILVIGGKRLSTSKVIREIQKLFPRKWARHVRVYKSIDEVNVSGITPGLDVLSLQDLDESPFSHTITAHELFIMAGRSGSSWVAAVTNANTSIARVHGTHVIPIDEQDCSPERLSAIANYILSWSISTVAGPHASVLLFEAHDSLAASVKAQLAAAGGKAFFASTRTHGTPANGIKIHALASKRSIQRVVPHDVQLFIDCSLDSSPAAATLTQSMPSNCISRQLDVQLVQEALRSAHRESVELLKEAFAFPGVESPAVPVVPAQTLAGRSFMSLKAQAYVTDWTTQVISTTVPPLSLEGLFRPDKTYFMAGMAGGLGLSICQWMIRNGAKHMVITSRNPQVNTATLEEAERVGATVKVLAMDLTNRESVEKVVQQIRETMPPIAGVCNAAMVLKDGFFVDMDVDQFNNTLAAKVIGSENLDSVFSSTPLDFFILLGSVASVIGNVGQSNYHAANLFMDSLVHQRRARGLAASIVHIAYVTDVGYVTREERDRQLDSHFRKVRLMPTSETDVHHAFAEAVKGGKPGSTSGYHDIIMGIEPLREQIPLDQQPLWMKNPRFAHFDQHAIHAQHERGSTGSIDNVRALVEKAEKEEEAIDAVMAAFCAKLESILQLTAGCINVQRPITDLGIDSLVAVEIRTWFLKELGADVPVVKILGGDTVQQLSTIATKKLLAKNMEAGAEKKSTIEKPAEATAPVPTSKQEESISSNSSYTKDDTPELEDEYESSVGVAAEEADEMRVRPGIIREERMSPAQARLWFMSQHLENSAAYNMAFRYKVKGPIGTARLKHALSFTTHKHECLRMCFYSHLEDGHPMQGLMASSLCNFKHTVHASEDDVAREMSRLSTCQWNLQYGHTMEVSLLSRDSEDHDLIIAYHHIVMDVIGLGVVLDDLNNAYNMKPVNKSAGSYIEFSVKQLEQQARGDFDKQLSFWEAEFRTIPQRLPRLPFARIGSPSGVAESVPDTYHQYRELNDTQFASLKATCQKLRISPFHFHLSLLQVLLSRYTNTDDLCIGIVDANRNDHRYAGTVGCFVNMVPVRLHVPPGKASFADVAQQTRRSALQALEHSAVPFDMILDKIKAPRSSRSTPLFQAALNYRTGSIWELPLGRAKMTMADVKDANNPYDLSLGIAETRTGCMVEVYVSSSAYGAEACATIMDAYMRLLDDFSNTPDLQINDCNIYGKPEIDSSLSIGQGPVIHFEWPATLSQRFLDMVRLHHGDPAVTDKTGTLTYSELLERVNGVSDTLIRHGCKSGTRIAVLCEPSIDTIVAMLAILHIGAVYVPLDVSLPTARHVAMIQSSKPSFVVNHASTDGQARECIGKIEFPIRRVVLDDVIEEEIRVTVPCLASPDACSIVLFTSGSTGTPKGIMLSQANFANHLALKTHLLGLGKETVLQQSSTGFDMSIVQMFCALANGGRLVIAPFDIRRDPIEMVSLVCSEHISLSIATPSEYLAWTRYGISSLKENTAWRHICMGGESVTRQLVLELRRLGLPNLRVTNCYGPTEITAAASFQPIDLGGQEDAHPDMVKYKVGKVLPNYTVSILDARGSPQPVNHTGEVCIGGAGVALGYISASDDAASKFIVTAQGQRMYRTGDRGRLLSDGTLLLFGRIEGDSQIKLRGIRVDLQEVELAVLEAADGLLSNVVVSQRGDVLIAHATVPPGEPEATLITEDDLNRVLRRLDLPQYFIPARIVILSSLPTNANGKLDRKAIAALPLPSCQSRADSGSEEEKMTIEEGELRLLWERVLPQVAPLTRIAPSSDFFLLGGNSLLLMKLQAAMKDSMNVMMSTRKLYQASTLREMARAVDKQRRSQAEHDDQREIDWAAETAIPKWLLNQIHEQSQSKQVVGAKSPVEKISVLMTGATTFLGGHLLKSLLESDKVSKIYCIAVLADDQHLLPENEKIESFNGSLLSPTLGLDATERVRLESTADIIVHAGGSGHCLNTYATLRIPNVISTHFLASMALPRSIPLLFLSSSRVVLLTGNTSPPAASVSGFPPATDGREGHMMSKWTSEVFLENLVGHLLASSPRHQQNPWTVSVHRPSVIVSEHAPNSDALNAILRYSILMQSSPRMDNVVGYLDLAQLDTVIAELRQSVIQLGSGQGKQESTNILFKHHSGGIKVPASELWSHLGKVYGITFDEVELDEWLRRAARAGIDPLITAYLEAIQANGAKMIFPYMGSD
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:34947016).  IliA assembles the backbone of ilicicolin H (PubMed:34947016).  The PKS portion and trans-acting enoyl reductase iliB work together to construct an octaketide, and two methyl groups are introduced by the MT domain during the chain assembly (PubMed:34947016).  The nascent chain is then condensed with tyrosine, catalyzed by the C domain, and the resulting PKS-NRPS hybrid is offloaded by the RED domain to form an advanced tetramic acid intermediate (PubMed:34947016).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  8-epi-ilicicolin H might then spontaneously convert to ilicicolin H to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (PubMed:34947016) (Probable).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase iliA, PKS-NRPS iliA, Ilicicolin H biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.