PharMolix/UniProtQA huggingface dataset:
Protein: RS3_METST
Sequence: MIEKDFVKEGLKRTRIDEYLETKLERAGYGGMDIQVTPVGTMVIVYAEKPGMVIGRGGKTVRAITKTLKNNFDLENPQVEVKEVDVPELNPRIMAHKVVAMLQRGMQFRRVAYSIIRRIMSAGAQGVEVTISGKIRGSRSACAKFNEGYIKKCGEPSIKYVKEGFATVQLKPGVLGIYVRIMPPEVTLPDNIEISEPEIVDVEEPVAQEVPEVQESEIVEEITGEDILEELSEESEIEEITEEIEDVETLEE
What is the function of this protein?
Binds the lower part of the 30S subunit head.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: HTPG_EHRRW
Sequence: MQGTVNSERLKFDAEVGKVLKLVIHSLYTNKDIFLRELISNASDACDKLRYQSLSNQDLMDAGSELKIVISVDKDKNRLYISDNGIGMNREDLINNLGTIAHSGTQKFLDAINSGASSQQGVVELIGKFGVGFYSAFMVASEVIVESCKAGESVGYQWKSSGDGEFVISQLESDQVSRGTRITLALKPEECEFVDKFRIEHIVTTYSYHINYPVYFLNDKGEEERLNSEAAIWTKAKDEISAEEHQNFFRTVAHVGGEPWMILHNKNEGVIEYTNLLYIPSIKPFDLFHPDRKCSVKLYVNKVFITEDNVQIIPQYLRFLKGIIDSSDLPLNISRETLQNNKIIEKIKRSLVKRVLSELKKKAESNIEDYTKFWDNFGSVLKEGLCESMNTEFREELISVCRFYSTHSNDSLISLEDYIERMKPEQNNIYYLTGNDLDSIKKSPQLEGFVSRGIEVLLLVDPVDDFWTNVVTDYQKVPLRSVIRADEDLEKFSDVEKDDESKESQNEDAQSKEKVDKFISYAAQVLTNLVSNVRVSKKLTDSPVCLAVADGSMDIRMERFLREQKQLNYKSTKILEINSKHPIVSKMIDQYAENGENAVLCNMLHLLLGQACILEGEELQNVSDFAERMNNVLSQIN
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_LISW6
Sequence: MTIYHFVGIKGSGMSALAQILHDKGFQVQGSDVDKYFFTQKALEEKQIPIMTFSADNINEGLTIIAGNAFPDTHEEIERALELGLPVIRYHKFLGQLIDGYTSIAITGSHGKTSTTGLLSHVVGAIRPTSYLIGDGTGSGTKNAQYFALEACEYQRHFLAYKPTYAIMTNIDWDHPDYFKSVDDVFNAFETLGKQVKKAVFALGDDEELRKLSLDIPIIYFGFDEENEFQAKNVIKETTGTRFDVYHRDEFLASFEIPAYGDHNVLNALSVIALCDYEGLPVEAVKKELKTFEGVKRRFSITEKGNQVLVDDYAHHPSEIRATVNAARQKYPDKKVVAVFQPHTFTRTRTFLQGFADSLNLADEVYLCDIFGSAREKTGNLTIADLAHKTKGNHIIKEEHTEELLKYPGAVILFMGAGDVQKFQAAYEKVLDNEVVTKSDFKKSAIN
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAF3_CAEEL
Sequence: MGDHHNLTGLPGTSIPPQFNYSQPGTSTGGPLYGGKPSHGLEDIPDVEEYERNLLGAGAGFNLLNVGNMANEFKPIITLDTKPPRDANKSLAFNGGLKLITPKTEVPDEHTPMMSPVNTTTKILQRSGIKMEIPPYLDPDSQDDDPEDGVNYPDPDLFDTKNTNMTEYDLDVLKLGKPAVDEARKKIEVPDASAPPNKIVEYLMYYRTLKESELIQLNAYRTKRNRLSLNLVKNNIDREFDQKACESLVKKLKDKKNDLQNLIDVVLSKGTKYTGCITIPRTLDGRLQVHGRKGFPHVVYGKLWRFNEMTKNETRHVDHCKHAFEMKSDMVCVNPYHYEIVIGTMIVGQRDHDNRDMPPPHQRYHTPGRQDPVDDMSRFIPPASIRPPPMNMHTRPQPMPQQLPSVGATFAHPLPHQAPHNPGVSHPYSIAPQTHYPLNMNPIPQMPQMPQMPPPLHQGYGMNGPSCSSENNNPFHQNHHYNDISHPNHYSYDCGPNLYGFPTPYPDFHHPFNQQPHQPPQLSQNHTSQQGSHQPGHQGQVPNDPPISRPVLQPSTVTLDVFRRYCRQTFGNRFFEGESEQSGAIIRSSNKFIEEFDSPICGVTVVRPRMTDGEVLENIMPEDAPYHDICKFILRLTSESVTFSGEGPEVSDLNEKWGTIVYYEKNLQIGEKKCSRGNFHVDGGFICSENRYSLGLEPNPIREPVAFKVRKAIVDGIRFSYKKDGSVWLQNRMKYPVFVTSGYLDEQSGGLKKDKVHKVYGCASIKTFGFNVSKQIIRDALLSKQMATMYLQGKLTPMNYIYEKKTQEELRREATRTTDSLAKYCCVRVSFCKGFGEAYPERPSIHDCPVWIELKINIAYDFMDSICQYITNCFEPLGMEDFAKLGINVSDD
What is the function of this protein?
Transcriptional regulator and common SMAD (co-SMAD), required to regulate entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions (PubMed:9334330).  Probable component of transcriptional regulatory complex with SMAD protein daf-5 (PubMed:14681186).  Acts antagonistically to SMAD signaling downstream of TGF-beta-like daf-7 signaling (PubMed:20081192).  Binds to the 5'-GTCTG-3' motif found in regulatory regions and may modulate the expression of genes involved in TGF-beta-like daf-7 and Notch lag-2 signaling (PubMed:20081192, PubMed:9834189, PubMed:28811311).  May regulate gene expression outside the dauer pathway (PubMed:9834189).
What are the official names of this protein?
Smad protein daf-3, Abnormal dauer formation protein 3.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome. Note=Localization observed during mitosis.
Protein: PSO2_YEAST
Sequence: MSRKSIVQIRRSEVKRKRSSTASSTSEGKTLHKNTHTSSKRQRTLTEFNIPTSSNLPVRSSSYSFSRFSCSTSNKNTEPVIINDDDHNSICLEDTAKVEITIDTDEEELVSLHDNEVSAIENRTEDRIVTELEEQVNVKVSTEVIQCPICLENLSHLELYERETHCDTCIGSDPSNMGTPKKNIRSFISNPSSPAKTKRDIATSKKPTRVKLVLPSFKIIKFNNGHEIVVDGFNYKASETISQYFLSHFHSDHYIGLKKSWNNPDENPIKKTLYCSKITAILVNLKFKIPMDEIQILPMNKRFWITDTISVVTLDANHCPGAIIMLFQEFLANSYDKPIRQILHTGDFRSNAKMIETIQKWLAETANETIDQVYLDTTYMTMGYNFPSQHSVCETVADFTLRLIKHGKNKTFGDSQRNLFHFQRKKTLTTHRYRVLFLVGTYTIGKEKLAIKICEFLKTKLFVMPNSVKFSMMLTVLQNNENQNDMWDESLLTSNLHESSVHLVPIRVLKSQETIEAYLKSLKELETDYVKDIEDVVGFIPTGWSHNFGLKYQKKNDDDENEMSGNTEYCLELMKNDRDNDDENGFEISSILRQYKKYNKFQVFNVPYSEHSSFNDLVKFGCKLKCSEVIPTVNLNNLWKVRYMTNWFQCWENVRKTRAAK
What is the function of this protein?
Required for DNA interstrand cross-link repair.  This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs).  This protein has 5' exonuclease activity on single-stranded and double-stranded DNA, which appears to be necessary for the processing of DNA double strand breaks prior to ligation.
What are the official names of this protein?
DNA cross-link repair protein PSO2/SNM1.
What is the protein family that this protein belongs to?
Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DBNL_HUMAN
Sequence: MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
What is the function of this protein?
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis.  Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL.  Does not bind G-actin and promote actin polymerization by itself.  Required for the formation of organized podosome rosettes (By similarity).  May act as a common effector of antigen receptor-signaling pathways in leukocytes.  Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
What are the official names of this protein?
Drebrin-like protein, Cervical SH3P7, Cervical mucin-associated protein, Drebrin-F, HPK1-interacting protein of 55 kDa, HIP-55, SH3 domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the ABP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytosol. Synapse. Perikaryon. Cell projection, neuron projection. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Early endosome. Cell projection, dendrite. Postsynaptic density. Note=Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes.
Protein: GLGC_BACAH
Sequence: MAQKQKCVAMLLAGGKGSRLSALTKNLAKPAVPFGGKYRIIDFTLSNCANSGIETVGILTQYQPLELHNYIGIGNAWDLDRVSGGVTVLPPYAESSGVKWYTGTASAIYQNLNYLSQYEPDYVLILSGDHIYKMDYSKMLDYHIEKEADVSISVIEVPWDEASRFGIMNTNEEMEIVEFEEKPQFPRSNLASMGIYIFNWAILKEYLEMDARNPESSNDFGKDVLPLLLDEGKKLMAYPFEGYWKDVGTVKSLWEANMDLLRDETSLNLNDRDWRIYSVNPNEPPQYIAEKAKVEESLINEGCVIEGDVKHSVLFQGVTVEEGSMVIDSVVMPGAKIGKNVVIERAIVGSEMVIEDGTIIRPEKNVDDVVLIAEGK
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: RECR_CHLPD
Sequence: MRYTSGAIETLIDEFARLPGIGRKTAQRLCMHMLNEPRTAAEKLAKALLDVKDRVIRCSECQNVTDRDSDPCVLCRSSGRDRTVICVVESPVDLLAFEKTGHYKGLYHVLHGVISPLDGIGPDDIKVRELLARVSRPEESLQVREVVLALNPTVEGETTSLYISRLLKPLGIAVSKIARGIPVGAELEFIDEATLSRAMEGRSAM
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: PG034_VACCW
Sequence: MVKNNKIQKNKISNSCRMIMSTDPNNILMRHLKNLTDDEFKCIIHRSSDFLYLSDSDYTSITKETLVSEIVEEYPDDCNKILAIIFLVLDKDIDVDIKTKLKPKPAVRFAILDKMTEDIKLTDLVRHYFRYIEQDIPLGPLFKKIDSYRTRAINKYSKELGLATEYFNKYGHLMFYTLPIPYNRFFCRNSIGFLAVLSPTIGHVKAFYKFIEYVSIDDRRKFKKELMSK
What are the official names of this protein?
Protein OPG034.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG034 family.
Protein: NFE2_RHIML
Sequence: MTDLIGFYSDHKIAAPLAIAQRSAKFKPFAAEIARRGILQIATCARLEFYGEKSVLEDIDGKPFFGFSYGRVEGAISIAERLATIAAGVHSQILGEGFISGQLMQAIESGDPNLSIFKVARVAVDLGSAARKRQEFFAEFDYVQIVEDIIADRFSDKAPLDRIYIIGAGMLGQELIRGNVGERFRSTVVITRNPKKLRKRLNTGPKTNVTFMRPSEVGRTREPGSMVVIATTDVDNKYKAILQETLLRLGPRIILDLSSIPVLTREAIGELDYVNMYGDEFLRFIEQNNQRLAPKLPLVVSDIKAALGAAV
What is the function of this protein?
Responsible for the nodulation efficiency and competitive ability of strain GR4 on alfalfa roots.
What are the official names of this protein?
Protein nfe2.
Protein: RIMO_RHOPA
Sequence: MQQATAPKISFVSLGCPKALVDSERIITRLRAEGYELARKHDGADLVIVNTCGFLDSAKQESLAAIGEAMATNGKVIVTGCMGAEPEQIEAAYPGVLSITGPQQYESVLEAVHRARPALHNPHLDLVPPQGVRLTPRHYAYLKISEGCNNRCSFCIIPKLRGDLVSRPAGDVLREAEKLVAAGVKELLVISQDTSAYGVDVKYAESPWKDRAVRAKFLDLASELGELGAWVRLHYVYPYPHVDEVIGLMADGKVLPYLDIPFQHASPDVLKLMKRPAAQDKTLDRIKRWREQCPDLALRSTFIVGFPGETERDFEFLLEWLDEAEIDRLGAFKYEPVAGAPSNALPDQIADEVKQERWNRLMARQQAISARRLKRKVGTRQQVIIDEIGPTVAKGRSKADAPDIDGAVYLSSRRPLRVGEIVTAKIDRADAYDLHGTVAGF
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACDE2_METAC
Sequence: MVDTTKNTKLFTSYGVTTSKTTTPEIAAKLISKAKRPLLVVGTKVLDPELLDRAVKIAQKANIPIAATGSSMPGFVGKDVDAKYINLHQLGFYVTDPNWPGLDGNGTYDTLIVLGHIKYYINQVLSGTKNFSTVKAIAIERNYIQNATMSFGNLSKADHYAALDELIDAL
What is the function of this protein?
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.  The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.  The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.
What are the official names of this protein?
Acetyl-CoA decarbonylase/synthase complex subunit epsilon 2, ACDS complex subunit epsilon 2, ACDS complex carbon monoxide dehydrogenase subunit epsilon 2, ACDS CODH subunit epsilon 2.
What is the protein family that this protein belongs to?
Belongs to the CdhB family.
Protein: CA2D2_HUMAN
Sequence: MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRPTSGPPRPLWLLLPLLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRANCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAKQVQWTNVYEDALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFYLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNHGYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSDGPEQCELVQRPRYRRGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQVLVHASRRL
What is the function of this protein?
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.  Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G) (PubMed:15111129, PubMed:23339110).  Overexpression induces apoptosis.
What are the official names of this protein?
Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2.
What is the protein family that this protein belongs to?
Belongs to the calcium channel subunit alpha-2/delta family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Note=Colocalizes with CACNA1A in lipid raft fractions.
Protein: NDBP_LYCMC
Sequence: MNKRVLLVIFFVTLLVADEVNSFSFFRKAKGFLKKIWKSKIARRLREKGMKALKNYANDVLNGPAEAPAPAAAAPEEPPVEQRRRRR
What is the function of this protein?
Inhibits angiotensin-converting enzyme (ACE), but does not serve as substrate for the enzyme.  Potentiates bradykinin (BK) on the isolated guinea pig ileum as well as the isolated rat uterus for contraction.  Also potentiates in vivo the depressor effect of BK on arterial blood pressure in the normotensive anesthetized rat.
What are the official names of this protein?
Bradykinin-potentiating peptide NDBP12, BPP-12.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Long chain multifunctional peptide (group 2) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CT930_CHATD
Sequence: MFGTKALRAAQHAVRTPSIKFIGKRTIPAVVDHTPQPHPASPTKTLPASFLSSHATFSVYRDHAQQFGPLRKTITPNAGIGGSPAVALGPVEPPQGVYFDRNDLPERFRRQPLTPDEIEAIETGGGHLLYRGSYL
What are the official names of this protein?
Uncharacterized protein CTHT_0020930_1.
Protein: PROFQ_OLEEU
Sequence: MSWQAYVDDHLMCDIEDHEGHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVFGIYEEPVTPGQCNMVVKRLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-2, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MUTS_RHILO
Sequence: MNMHSPNEPDAPEVMTTPQPGTAAVTPMMEQFIEIKAANPDSLLFYRMGDFYELFFDDAEKASRALGIVLTKRGKHQGHDIPMCGVPVHAADDYLQKLIGQGFRVAVCEQIEDPAEAKKRGSKSVVRRDVVRLVTPGTITEDKLLAPSESSFLMALGRVKGGSDHSFAIAWIDISTGAFRVAETTADRLLADIFRVDPRELIVAEPVFHDPELRPVFDVLGRVANPQPPSLFDSASATGRIARFFDVATPDSFGTFSRAELSAISGAIAYVEKTQKAERPPLSRPEREEQGSTLFIDPATRGNLELLRTLSGSREGSLFKAIDRTVTGGGARLLADRLMAPLTDPAAIGARLDSVSFFRTETRLCQAVRASLKSVADMPRALSRLALNRGGPRDLGALRAGFEAAGAIVEIFAATALPQELAEAMAAIRALPQALAQHLIQALGEELPLLKRDGGFLRGGYHPELDEMRALRDESRKVIAGLERSLIEETGIRSLKIRHNNVLGYYIEVTANHHAIMTGSDGAKARFIHRQTMANAMRFTTTELAELETKIANAADRALGIELAAFEALTAQAVGEAEKIRAGADALAAIDVSAALALLSESEAWCRPVVDSSLAFEISGGRHPVVEQALRRSGEGPFVANDCDLSPEGNAKNGAIWLLTGPNMGGKSTFLRQNALIAILAQTGSFVPATSAHIGVVDRLFSRVGASDDLARGRSTFMVEMVETAAILNQAGERALVILDEIGRGTATFDGLSIAWAAVEYLHEKNRCRAIFATHFHEMTSLAGKLARLHNVTMRVKEWEGDVVFLHEVGKGAADRSYGVQVARLAGLPEAVVDRAKQVLHQLEEGEVSGKTNRLVDDLPLFSVAMKREAPKPVKSDALGAALGDINPDEMTPREALEALYRLKGLAGK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: HIS5_SYNJB
Sequence: MGAVRLAVIDYEAGNLHSACKGLERAGAEVQLVTEPTGLAAFDGIVLPGDGAFDPAMQQLRARGFGKAIREAVERQQPFLGICLGLQVLFESSEEGTEPGLSIVPGRVQRFRPEAGLRIPHMGWNQLQLTQAHSPLWAGIPDQTWAYFVHSYHGVPSDPAWVAATTQHGSQTCVAAIARGALFATQFHPEKSGPYGLKMLRNFVEFVARCSPLSAPRA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMK_SHELP
Sequence: MRIAILSRNENLYSTQRLKEAGEARGHEVDIIDTLHCYMDITSSNPTVRYMGKVLPKYDAVIPRIGSSITFYGTAVVRQFEMMGTFCVNESVAISRSRDKLRSLQLLSRKGIGLPRTGFASKPDKIQDLIKNVGGAPLVIKLLEGTQGIGVVLAETNKAAESVIEAFMGLKANILVQEFIKEAGGADIRCFVVGDKVVAAMKRQAAEGEFRSNLHRGGVAQLVRLSKDERATALNAAKAMGLNLCGVDILQSNNGPVVMEVNSSPGLEGIEQATGKDVAGLIYEFIEKKAKPNANRTRGKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: PP319_ARATH
Sequence: MFSLSLIQPRLRISEIPVTQSYKSPTICYSSDSRTKREEQRHVRLPGFRLVSGKRASFDSGFSGFKGENVNQDDSSSFDSERVDYALLAEWLQSSNGMRLIKRIHAMALKCFDDQVIYFGNNLISSCVRLGDLVYARKVFDSMPEKNTVTWTAMIDGYLKYGLEDEAFALFEDYVKHGIRFTNERMFVCLLNLCSRRAEFELGRQVHGNMVKVGVGNLIVESSLVYFYAQCGELTSALRAFDMMEEKDVISWTAVISACSRKGHGIKAIGMFIGMLNHWFLPNEFTVCSILKACSEEKALRFGRQVHSLVVKRMIKTDVFVGTSLMDMYAKCGEISDCRKVFDGMSNRNTVTWTSIIAAHAREGFGEEAISLFRIMKRRHLIANNLTVVSILRACGSVGALLLGKELHAQIIKNSIEKNVYIGSTLVWLYCKCGESRDAFNVLQQLPSRDVVSWTAMISGCSSLGHESEALDFLKEMIQEGVEPNPFTYSSALKACANSESLLIGRSIHSIAKKNHALSNVFVGSALIHMYAKCGFVSEAFRVFDSMPEKNLVSWKAMIMGYARNGFCREALKLMYRMEAEGFEVDDYIFATILSTCGDIELDEAVESSATCYLETS
What is the function of this protein?
Required for proper chloroplast development (Ref. 7, PubMed:24144791).  Involved in the regulation of plastid gene expression probably through regulation of plastid-encoded polymerase (PEP) dependent chloroplast transcription (PubMed:24144791).  Required for RNA editing of several chloroplastic transcripts, especially accD transcripts (PubMed:24144791, PubMed:26123918).  Required for processing of the chloroplastic rpoA pre-mRNA (Ref. 6, Ref. 7).  Required for the monocistronic rpoA transcript processing from the rpl23-rpl2-rps19-rpl22-rps3-rpl16-rpl14-rps8-rpl36-rps11-rpoA polycistron.  Binds the intergenic sequence of rps11-rpoA for rpoA monocistronic RNA cleavage (Ref. 7).
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At4g18520, chloroplastic, Protein PIGMENT-DEFICIENT MUTANT 1, Protein SEEDLING LETHAL 1.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-A subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TOP1_VACCA
Sequence: MRALFYKDGKLFTDNNFLNPVSDDNPAYEVLQHVKIPTHLTDVVVYEQTWEEALTRLIFVGSDSKGRRQYFYGKMHVQNRNAKRDRIFVRVYNVMKRINCFINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKNKHIEISPDEIVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLFNKLSERKVYECIKQFGIRIKDLRTYGVNYTFLYNFWTNVKSISPLPSPKKLIALTIKQTAEVVGHTPSISKRAYMATTILEMVKDKNFLDVVSKTTFDEFLSIVVDHVKSSTDG
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
What are the official names of this protein?
DNA topoisomerase 1B, TopIB, DNA topoisomerase I, Late protein H6.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
Protein: ZRT1_YEAST
Sequence: MSNVTTPWWKQWDPSEVTLADKTPDDVWKTCVLQGVYFGGNEYNGNLGARISSVFVILFVSTFFTMFPLISTKVKRLRIPLYVYLFAKYFGSGVIVATAFIHLMDPAYGAIGGTTCVGQTGNWGLYSWCPAIMLTSLTFTFLTDLFSSVWVERKYGLSHDHTHDEIKDTVVRNTAAVSSENDNENGTANGSHDTKNGVEYYEDSDATSMDVVQSFQAQFYAFLILEFGVIFHSVMIGLNLGSVGDEFSSLYPVLVFHQSFEGLGIGARLSAIEFPRSKRWWPWALCVAYGLTTPICVAIGLGVRTRYVSGSYTALVISGVLDAISAGILLYTGLVELLARDFIFNPQRTKDLRELSFNVICTLFGAGIMALIGKWA
What is the function of this protein?
High-affinity zinc transport protein.
What are the official names of this protein?
Zinc-regulated transporter 1, High-affinity zinc transport protein ZRT1.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PEPQ_LACHE
Sequence: MNLDKLQQWLQDSNNDIAYISNPITISYFTGYSMDPHERIFALLVFKDANPFIFCPALNVEEAKNSEWNGDVFGYLDSEDPWELIADNVRKRTSDTHTWAIEKDDLSVAHYQYLRGEFPNASFTNDVSSFIERLRLYKTPEEIKKLQGAGAEADFAFKIGFDAIRTGVTERSIAGQIDYQLKIQKGVMHESFETIVQAGKNAANPHLGPTMNTVQPNELVLFDLGTMHDGYASDSSRTVAYGTPSDKQREIYEVDREAQQAAIEAAKPGITAEELDSVARDIITKAGYGEYFIHRLGHGIGKNVHEYPSIVQGNDLVLEEGMCFSIEPGIYIPGFAGVRIEDCGVVTKDGFKTFTHTDKDLKIIPIRD
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
What are the subcellular locations of this protein?
Cytoplasm.