PharMolix/UniProtQA huggingface dataset:
Protein: GEMI6_BOVIN
Sequence: MNEWMKKGPLEWQDYTYKAVSVTASDKEYKGWVLTTDPVSANIVLVNFLEDGSMSVTGIMGHAVQTVEIVNEGDHSVREKLMHLFMSGDCKAYSPEDLEKRKNSLKKWLEKNHIPITEQRDSRKTLCVAGVLTIDPPYGPENCNSSNEIILSRVQDLIQGHLEASQ
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity).
What are the official names of this protein?
Gem-associated protein 6, Gemin-6.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, gem. Cytoplasm. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity).
Protein: RL3_BUCAP
Sequence: MIGLVGKKLGMSRIFTKEGSSIPITVIQIQENRITQIRNIKTDKYYAIQVTTGLKKLNRLKKPESGHFLKSGVIPGRGLWEFRINNNEKFQIGQSIKINIFNDIKKVDVTGISKGKGFSGTVKRWNFRTQDATHGNSLSHRVPGSIGQNQTPGRVFKGKKMAGHLGNNRVTVQNLNIVKIDQNRNLLLVKGAVPGPTGSDLIVKPAIKI
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: TRPR_XYLFT
Sequence: MSREQAFEMLIKILCKTDSTDDMKLILECILTRSEMEDLIDRIRIYNELLNTSNSQREVASKLGVSITKITRGAANLQDNNIKDFLRKKISY
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription (By similarity).
What are the official names of this protein?
Trp operon repressor homolog.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRB1L_HUMAN
Sequence: MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDPDQHPFSSADVKPKVEDLDKDLVNRYTQNGSLDFSNNLTVNEMEDDEDDEEMSDSNSPPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILVCAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRSSQGVLSKGPLICWKECRSRQSSASCHSIKPSSSVSSTVTPENGTTNGYKSGFTQTDAANGNSSHGGKGSASSSTPAHTGNYSLSPRPSYASGDQATMFISGPPKKRHRGWYPGSPLPQPGLVVPVPTVRPLSRTEPLLSAPVPQTPLTGILQPRPIPAGETVIVPENLLSNSGVRPVILIGYGTLPYFYGNVGDIVVSPLLVNCYKIPQLENKDLEKLGLTGSQFLSVENMILLTIQYLVRLGPDQVPLREEFEQIMLKAMQEFTLRERALQIGAQCVPVSPGQLPWLARLIASVSQDLVHVVVTQNSLAEGISETLRTLSEMRHYQRLPDYVVVICASKIRGNEFCVVVLGQHQSRALAESMLTTSEFLKEISYELITGKVSFLASHFKTTSLGDDLDKLLEKMQQRRGDSVVTPFDGDLNECVSPQEAAAMIPTQNLDLDNETFHIYQPQLTVARKLLSQVCAIADSGSQSLDLGHFSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLGLEENGTAHQRAEKYVVRLDNEIQTKFEVFMRRVKQNPYTLFVLVHDNSHVELTSVISGSLSHSEPSHGLADRVINCREVLEAFNLLVLQVSSFPYTLQTQQSRISSSNEVHWIQLDTGEDVGCEEKLYFGLSEYSKSLQWGITSPLLRCDETFEKMVNTLLERYPRLHSMVVRCYLLIQQYSEALMALTTMASLRDHSTPETLSIMDDLISSPGKNKSGRGHMLIIRVPSVQLAMLAKERLQEVRDKLGLQYRFEIILGNPATELSVATHFVARLKSWRGNEPEEWIPRTYQDLDGLPCIVILTGKDPLGETFPRSLKYCDLRLIDSSYLTRTALEQEVGLACCYVSKEVIRGPTVALDLSGKEQERAAVSENDSDELLIDLERPQSNSSAVTGTSGSIMENGVSSSSTADKSQKQSLTPSFQSPATSLGLDEGVSASSAGAGAGETLKQECDSLGPQMASSTTSKPSSSSSGPRTLPWPGQPIRGCRGPQAALPPVVILSKAAYSLLGSQKSGKLPSSSSLLPHADVAWVSSLRPLLNKDMSSEEQSLYYRQWTLARQHHADYSNQLDPASGTRNFHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINTDHNESSEVSQSEGEPWPDIESFSKMPFDVSVHDPKYSLMSLVYTEKLAGVKQEVIKESKVEEPRKRETVSIMLTKYAAYNTFHHCEQCRQYMDFTSASQMSDSTLHAFTFSSSMLGEEVQLYFIIPKSKESHFVFSKQGKHLESMRLPLVSDKNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHLHLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGIKRQCVWPFIVMMDDSCVLWNIHSVQEPSSQPMEVGVSSKNVSLKTVLQHIEATPKIVHYAILGIQKWSSKLTSQSLKAPFSRCHVHDFILLNTDLTQNVQYDFNRYFCEDADFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDFIIKPKIMVSESLAPILPLQYICAPDSEHTLLAAPAQFLLEKFLQHASYKLFPKAIHNFRSPVLAIDCYLNIGPEVAICYISSRPHSSNVNCEGVFFSGLLLYLCDSFVGADLKKFKFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRLRDEFQTANSSDDKPLYFLTGRHV
What is the function of this protein?
Plays a major role in early metanephros and genital development.
What are the official names of this protein?
GREB1-like protein, Growth regulation by estrogen in breast cancer 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the GREB1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TRMH_ECOLI
Sequence: MNPTRYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMASAAAGSNSWVQVKTHRTIGDAVAHLKGQGMQILATHLSDNAVDFREIDYTRPTCILMGQEKTGITQEALALADQDIIIPMIGMVQSLNVSVASALILYEAQRQRQNAGMYLRENSMLPEAEQQRLLFEGGYPVLAKVAKRKGLPYPHVNQQGEIEADADWWATMQAAG
What is the function of this protein?
Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.  Type II methylase, which methylates only a subset of tRNA species.
What are the official names of this protein?
tRNA (guanosine(18)-2'-O)-methyltransferase, tRNA [Gm18] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: 1A1D_BURO0
Sequence: MNLQRFPRYPLTFGPTPIQPLKRLSAHLGGKVELYAKREDCNSGLAFGGNKTRKLEYLVPDALAQGADTLVSIGGVQSNQTRQVAAVAAHLGMKCVLVQEHWVNYEDPVYDRVGNIQLSRMMGADVRLVSDGFDIGIRRSWEEAMESVRQAGGKPYPIPAGCSEHPLGGLGFVGFAEEVRAQEAQLGFKFDYVVVCSVTGSTQAGMVVGFAADGRADRVIGIDASAKPEQTREQITRIARHTAELVELGRDIVEQDVVLDTRYGGPEYGLPSDGTLEAIRLCARLEGMLTDPVYEGKSMHGMIDKVRLGEFEPGSKVLYAHLGGAPALSAYNGIFRNG
What is the function of this protein?
Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate.  Allows growth on ACC as a nitrogen source.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate deaminase, ACC deaminase, ACCD.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: REP_CALCV
Sequence: MPRNPKSFRLAARNIFLTYPQCDIPKDEALQMLQTLSWSVVKPTYIRVAREEHSDGFPHLHCLIQLSGKSNIKDARFFDITHPRRSANFHPNIQAAKDTNAVKNYITKDGDYCESGQYKVSGGTKANKDDVYHNAVNAGCVEEALAIIRAGDPKTFIVSYHNVRANIERLFTKAPEPWAPPFQLSSFTNVPDEMSSWADDYFGRSAAARAERPISIIVEGDSRTGKTMWARALGPHNYLSGHLDFNSKVFSNNAEYNVIDDIAPHYLKLKHWKELIGAQRDWQSNCKYGKPVQIKGGIPSIVLCNPGEGSSYISFLNKEENASLRAWTTKNAKFITLEAPLYQSTAQDC
What is the function of this protein?
Essential for the replication of viral ssDNA.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific region at the genome origin of replication.  It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities (By similarity).
What are the official names of this protein?
Replication-associated protein, Rep, 40.2 kDa protein, Protein AC1, Protein AL1.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: AROQ_SODGM
Sequence: MADKFHILLLNGPNLNLLGTREPDKYGHTTLADITADLSALAGSLGAEFSHFQSNAEHALIDRIHQARGNTDFIVINPAAFTHTSVALRDALLAVNIPFIEIHLSNVHAREPFRHHSYLSDIAIGVICGLGADGYHFALQTAVKRLSTSN
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: GLPK_ACIAD
Sequence: MSYLLALDQGTTSSRAIIFDEKGQIHATAQRETRIKTPNSGWVEQDANEIWSSQIAVIQQALASAHILAKDIKALGLTNQRETTVVWDKRTGKALAPAIIWQDRRAAQWCNTLIENGMLVQVQQKTGLRIDPYFSAGKLVWLLENIAGFRILAEQGHAAFGTIDSWLVWNLTQGAEHIIEASNASRTMLMNLSTQMWDEDLLNKFNIPAAILPKIISSDAYVADTAQGLLGSTIPITGILGDQQAALFGQSCFEVGSAKNTYGTGCFMLFNTGDQLQFSQNQLLTTLAWQCQNQTRYALEGSVFMAGAIVQWLRDGLGLIQHSAQVEQLASQVQSTEGVVLVPAFTGLGAPHWDSEARALLCGMSRGTTKAHIARAALEAIAFQVSDVLCAMQSDLSRPLKELRVDGGASQNDMLMQFQADILNVPVLRPKMLESTAWGAAAMAGLKAGVFTNLDEIAASWQLDRTFEPKMKNDERESRLCEWSQALKRAKSNLI
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: SERC_DESPS
Sequence: MADRVYNFSAGPATLPFEVLEQAGKDIVNFKETGSGLIEISHRSPEFIEVIEKTESLVRELLEVPDNYKVLFLQGGASSQFFMVPMNLLGAGKKATYLNTGTWAKKAIKEAQLFGDIDVAYSSEESIFNHVPANDAYQVAEESEYLYFASNNTIYGTQFETMPQSKKMLVADMSSDIFSRKVDVSKFGLIFAGAQKNLGPAGVTLVIIRDDLLEKTPAHTPTMLSYKTHADKGSMFNTPPCFAIYVMGEVLAWLKNLGGVEKIEEINREKAALLYSQIDASDYYRVHAQDGSRSLMNVTFNLPTAELEAKFIAEASALQMKGLKGHRSIGGCRASIYNAFPREGVVKLVEFMQVFAANNPA
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPY1_SCHPO
Sequence: MQGFKIARHFELPTAPSQFFAGSSLNRLSFLRSNREFLNKAFYDHTTRFLPFCDLNPALLVKDDKLVTLSYPQISKYFTFSPFEHTDKQIAERFSKGESLPVLVYMGNEERNGPTDNWSQHNVFAIDITGIDELQQSIRDNGGTFVNLRSIFTEQYQLSASDSGACAFARSILDWISRYRFCPGCGKRNIPTMGGTKLVCSDVLLNDDSNCPSKKGINNYQYPRTDPCVIMVILSHDMQHILLGRALRHPKGLYACLAGFLEPGESLEEAVVRETYEESGVDVEKVLYYASQPWPFPQSLMLACFGIARKNAKIQRDKDLELEDVRFFSREEVLRSLEWDAKDGPAPILFPPKLSIARNLIQAFAYDDWTNSQVKM
What is the function of this protein?
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.  The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity).  Mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity).
What are the official names of this protein?
NAD-capped RNA hydrolase, DeNADding enzyme, Probable NADH pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudC subfamily.
Protein: TLP_DESRM
Sequence: MAKPDNRNDNVEKLQEMVQDTIENLEEAHETLQNNSLSRDQRQAIMEKNKRREESIRSFRNEIKDEYQDLH
What are the official names of this protein?
Protein Tlp homolog.
What is the protein family that this protein belongs to?
Belongs to the Tlp family.
Protein: NADE_BACVZ
Sequence: MSIQKQIMNDLHVKPSIDPKQEIEDRVNFLKQYLKKTGAKGFVLGISGGQDSTLAGRLAQLAAESIREEGGNAEFIAVRLPHGTQQDEDDAQMALKFIKPDKSWTFDIKSAVSAFTDQYKKDTGDQLSDFNKGNVKARMRMIAQYAIGGQEGLLVIGTDHAAEAVTGFFTKYGDGGADLLPLTGLTKRQGRRLLEELGAPERLYLKLPTADLLDEKPQQTDETELGITYNDIDDYLEGKDVSSEVIEALEKRYLSTEHKRQVPASMFDDWWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: UVRC_STAA2
Sequence: MEDYKQRIKNKLNVVPMEPGCYLMKDRNDQVIYVGKAKKLRNRLRSYFTGAHDAKTTRLVGEIRRFEFIVTSSETESLLLELNLIKQYQPRYNILLKDDKSYPFIKITKEKYPRLLVTRTVKQGTGKYFGPYPNAYSAQETKKLLDRIYPYRKCDKMPDKLCLYYHIGQCLGPCVYDVDLSKYAQMTKEITDFLNGEDKTILKSLEERMLTASESLDFERAKEYRDLIQHIQNLTNKQKIMSSDKTIRDVFGYCVDKGWMCIQVFFIRQGNMIKRDTTMIPLQQTEEEEFYTFIGQFYSLNQHILPKEVHVPRNLDKEMIQSVVDTKIVQPARGPKKDMVDLAAHNAKVSLNNKFELISRDESRTIKAIEELGTQMGIQTPIRIEAFDNSNIQGVDPVSAMVTFVDGKPDKKNYRKYKIKTVKGPDDYKSMREVVRRRYSRVLNEGLPLPDLIIVDGGKGHMNGVIDVLQNELGLDIPVAGLQKNDKHQTSELLYGASAEIVPLKKNSQAFYLLHRIQDEVHRFAITFHRQTRQKTGLKSILDDIDGIGNKRKTLLLRSFGSIKKMKEATLEDFKNIGIPENVAKNLHEQLHK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_SHESR
Sequence: MQLNSTEISDLIKQRIEQFEVVSESRNEGTIVAVSDGIIRIHGLADVMQGEMIELPGSRFAIALNLERDSVGAVVMGPYADLAEGVKVKTTGRILEVPVGRGLLGRVVNTLGEPIDGKGAIDNDGFSPVEVIAPGVIERKSVDQPVQTGYKAVDAMIPIGRGQRELIIGDRQTGKTAMAIDAIINQRDSGIKCVYVAVGQKASTIANVVRKLEEHGALANTIVVVATASEAAALQYLAPYSGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLKRPPGREAYPGDVFYLHSRLLERASRVNEEYVEKFTKGAVTGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETDLFNSGLRPAVNPGISVSRVGGAAQTKIIKKLSGGIRTALAQYRELAAFSQFASDLDDATRAQLEHGVRVTELMKQKQYAPMSVAAQAVSIFAAEKGYLKGVELNKVGDFEAALLSYMNSEHAALIKLINETGDYNADIEAELKAGLDKFVATQTW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YBN5_SCHPO
Sequence: MPVSVSDSFVFRNIFGDAEIRKIWSDENRTQEYLNWEAALARAEASLGIIPKYAGEEIQRVCKVENIDFSKLEEETINIGYPVLGVVHQLANLCSGDSGKYCHWGATTQDVTDSATVRQMIDSFKIIKGYLEKAIELATVLVIKHRETTMAGRSNLQQAVPITFGFKMARFVATLRRHHQRLCELLPRVSVLEFGGACGTLASLENKGLMVQQKLAEELGLLQPEIAWHTERDRIAEAGCFLGMLTGTLAKFATDIKLLMQTEVAEVFEPFKANRGSSSTMPQKRNPISCVYITASTSFVRQGVAALLDAMVEDHERATGAWEIEWIVLPDVFVHTVGTLKQTVFLLEGLEVHPSRMNENLSITNGLIVSEAVMMALAPKLGRDEAHDLVYRLCHLSIQENKPLVELLLAERQVTNYLSKEEVTSLLNPENYLGSTFEMIERALQIP
What are the official names of this protein?
Uncharacterized protein C8E4.05c.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL22_PARP8
Sequence: MEVKAIHRGARISAQKTRLVADQIRGLPVDKALNVLTFSPKKAAGIVKKVVLSAIANAEHNEGADIDELKIKSIYVDKAASLKRFTARAKGRGNRIEKQSCHITVTVGN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: TLR2_BOVIN
Sequence: MPRALWTAWVWAVIILSTEGASDQASSLSCDPTGVCDGHSRSLNSIPSGLTAGVKSLDLSNNDITYVGNRDLQRCVNLKTLRLGANEIHTVEEDSFFHLRNLEYLDLSYNRLSNLSSSWFRSLYVLKFLNLLGNLYKTLGETSLFSHLPNLRTLKVGNSNSFTEIHEKDFTGLTFLEELEISAQNLQIYVPKSLKSIQNISHLILHLKQPILLVDILVDIVSSLDCFELRDTNLHTFHFSEASISEMSTSVKKLIFRNVQFTDESFVEVVKLFNYVSGILEVEFDDCTHDGIGDFRALSLDRIRHLGNVETLTIRKLHIPQFFLFHDLSSIYPLTGRVKRVTIENSKVFLVPCLLSQHLKSLEYLDLSENLMSEETLKNSACKDAWPFLQTLVLRQNRLKSLEKTGELLLTLENLNNLDISKNNFLSMPETCQWPGKMKQLNLSSTRIHSLTQCLPQTLEILDVSNNNLDSFSLILPQLKELYISRNKLKTLPDASFLPVLSVMRISRNIINTFSKEQLDSFQQLKTLEAGGNNFICSCDFLSFTQGQQALGRVLVDWPDDYRCDSPSHVRGQRVQDARLSLSECHRAAVVSAACCALFLLLLLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPRRDICYDAFVSYSERDSYWVENLMVQELEHFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIDKKAIPQRFCKLRKIMNTKTYLEWPVDETQQEGFWLNLRAAIRS
What is the function of this protein?
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components.  Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).  May also promote apoptosis in response to lipoproteins.  Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway.  Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
What are the official names of this protein?
Toll-like receptor 2.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.
Protein: APT_HAEIG
Sequence: MTTQLDLIKSSIKSIPNYPKEGIIFRDITTLLEVPAAFKATIDLIVEQYRDKGITKVLGTESRGFIFGAPVALALGLPFELVRKPKKLPRETISQSYQLEYGQDTLEMHVDAISEGDNVLIIDDLLATGGTVEATVKLVQRLGGAVKHAAFVINLPELGGEKRLNNLGVDCYTLVNFEGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPPNK_METJA
Sequence: MVIMEGFKIAMKVIDEIDKKIKPLIGWEKADEVVKIGADGTPTKRIDVIAENMAINILEKFSGGILISEEIGLKVVGDELEYIFILDPIDGTYNALKSIPIYSTSIAVAKIKGEDKKLIRENINNIDWIKSFIANKYTINDLYVGIVKNLATGDLYYAIKGEGSFLEKDGEKIKIETKNIKDLKEASVGLFVYGLSNDLLEFLKERKVRRVRLFGSMALEMCYVVSGALDAYINVNENSRLCDIAGAYVICREGNAIVTNKNGKPLNMKLHLMERTSLIVSNKYLHKKLIALFGNRWIIKPVKFGIVVREDKEEAINLAIEICKYLKDKNIPFCVEDFLRERVGGDKFDISAISHIIAIGGDGTILRASRLVNGETIPIIAVNMGKVGFLAEFCKDEVFEIIDKVIYGEYEIEKRSKLSCKIIKDNRVIKTPSALNEMVVITKNPAKILEFDVYVNDTLVENVRADGIIVSTPTGSTAYSLSAGGPIVEPNVDCFIISPICPFKLSSRPLVISASNRIKLKLKLEKPALLVIDGSVEYEINKDDELIFEKSDSYAYFVKGQSFYNKLSRCLGIK
What is the function of this protein?
Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP.  Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively.  Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP.  Kinase can use ATP and other nucleoside triphosphates (UTP, TTP, CTP, GTP) as well as inorganic polyphosphate (poly(P)) as phosphoryl donors, however poly(P) is not considered to be the physiological phosphoryl donor.  NAD is the preferred substrate for the kinase, but NADH can also be used as phosphoryl acceptor.  Phosphatase can use NADP or NADPH as phosphoryl donor, but NADP is the preferred substrate.  Phosphatase also has an activity toward the terminal phosphate group at C-2 of adenosine in 2'-AMP and toward the phosphate group at C-1 of fructose 1,6-bisphosphate, but not toward inositol 1-phosphate.
What are the official names of this protein?
Bifunctional NADP phosphatase/NAD kinase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FETP_PSEAE
Sequence: MSRTVMCRKYHEELPGLDRPPYPGAKGEDIYNNVSRKAWDEWQKHQTMLINERRLNMMNAEDRKFLQQEMDKFLSGEDYAKADGYVPPSA
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: PFS2_KLULA
Sequence: MDPNTEGTTTKKYTSQRRTIDISASYDRLYFLKKHGQENSSYIEAETSYNAHILPPDAYGFHGHAINTATKFTHLSSNKVKHVIPALTWTPEGRRLVVATYNGEFSLWSGSSFNFESIMQAHDSAVTVMTYSHTGDWMVSGSADGELKIWQPNFNMVKVMDQAHMECVREISFSPTDQKFVSCSDDNVLKIWNFSNGQQERVLSGHHWDVKSCDWHPKMGLIVSGSKDNLIKFWDPRSGSCVSTMLGFKHTIISTKFQPKQGNLLSVISKDKTCKVYDIRQQAKELFSVRDDVDYMTLQWHPIDETVFTVGCYDGSIKHFDLSQENQPNKPTHNIPYAHEKCVTSLAYSPIGHIMASASKDRTIRFWTRSRAVDPNAFDDPTYNNEKVNAWYFGINNNINAVRNKTEHGVALPPSEDSNNNENGDGSRSVEPERPSVSTLPGLGSGLPGLSF
What is the function of this protein?
Required for 3'-end cleavage and polyadenylation of pre-mRNAs.  Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).
What are the official names of this protein?
Polyadenylation factor subunit 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: GYRB_CHLTR
Sequence: MDAQEKKYDASAITVLEGLQAVRERPGMYIGDTGVTGLHHLVYEVVDNSIDEAMAGFCTEVVVRILEDGGISISDNGRGIPIQIHEKESAKQGREISALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEKFIAKVFKDGQAYSMEFSRGAPLTTLQVLGPTDKRGTEVLFYPDPAIFSTCVFDRAILMKRLRELAFLNRGVTIVFEDDRDTGFDKVVFFYEGGIQSFVSYLNQNKEILFPNPIYMQGSRPGDDGDIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFSTALTRAVNSYIKAHNLSKSDKLSLTGEDIKEGLVAIVSVKVPNPQFEGQTKQKLGNSDVGSVSQQISGEVLTTFFEENPQIAKTIVDKVFVAAQAREAAKRARELTLRKSALDSARLPGKLIDCLEKDPEKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKVFQNQEIGSIIAALGCGIGKDNFNLSKLRYKRIIIMTDADVDGSHIRTLLLTFFYRHMSALIENECVYIAQPPLYRVSKKKDFRYILSEKEMDGYLLNLGTKESQIVFDDTLRDLRGEALETFVNLILEVESFIVSLEKKAIPFSEFLDMFRDGAYPLYYYPPESGKQGGSYLYSHEEKEAAIAANEESASRILELYKGSVLEELQRDLGDYGYDIRNYLHPKGSGITVSTEDPKISPYVCYTLKEVIDYLKGLGRKGIEIQRYKGLGEMNADQLWDTTMNPEQRTLVRVSLKDAVEADHIFTMLMGEEVPPRREFIESHALSIRMNNLDI
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.