PharMolix/UniProtQA huggingface dataset:
Protein: 3S157_MICAT
Sequence: MKTLLLTLVVVTIVCLDFGHTMICYNQQSSQPPTTTTCSEGQCYKQRWRDHRGWRTERGCGCPKAIPEVKLNCCKTDRCNG
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Three finger toxin MALT0057C, MALT0057C.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AROC_PSEA8
Sequence: MSGNTYGKLFTVTTAGESHGPALVAIVDGCPPGLELSARDLQRDLDRRKPGTSRHTTQRQEADEVEILSGVFEGKTTGTPIGLLIRNTDQKSKDYSAIKDLFRPAHADYTYHHKYGVRDYRGGGRSSARETAMRVAAGAIAKKYLAGLGIQVRGYMSQLGPIEIPFRSWDSVEQNAFFSPDPDKVPELEAYMDQLRRDQDSVGAKITVVAEGVPPGLGEPIFDRLDAELAHALMSINAVKGVEIGAGFASIAQRGTEHRDELTPQGFLSNNAGGILGGISSGQPIVAHLALKPTSSITTPGRSIDTAGEPVDMITKGRHDPCVGIRATPIAEAMMAIVLLDQLLRQRGQNADVRVDTPVLPQL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RL30_OPHHA
Sequence: MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTSEK
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_MYCGI
Sequence: MKPSATSSDLATGPQARAVWPLSEPALTYFPDVRFATSDRDLTAGAAPTPQSAAMVDDQPHVPVLLDRCVELLAPALTREGATLVDATLGAGGHSERFLTDFPGLRLIGLDRDPDALRIAGERLAPFADRITLVRTRYDGIADAVRDAAGGSVDAILFDLGVSSMQLDRVERGFSYSTDAPLDMRMDSGADLTAAQVLNSYDERALARVLREYGEEKFAGRIAAFIVRRRAVTPFTTTGELVELLYDAIPAPARRTGGHPAKRTFQALRIEVNAELESLRSAIPAALQALRPHGRLAVMAYQSLEDRIVKTAFAAATASRTPPGLPVELPGHGPEFVALTRGAERADAEEIERNPRSAPVRLRAVEKVGGE
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA1_HUMAN
Sequence: MEFPGLGSLGTSEPLPQFVDPALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAALAYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTREDSPPQAVEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPLNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGPPGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS
What is the function of this protein?
Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251).  It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.  Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781).
What are the official names of this protein?
Erythroid transcription factor, Eryf1, GATA-binding factor 1, GATA-1, GF-1, NF-E1 DNA-binding protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: SEH1_OSMMO
Sequence: MFVARSIAADHKDLIHDVSYDFHGRRMATCSSDQSVKVWDKSDNGEWNCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKQRGLSHWIKRTTLVDSRTSVTDVKFAPKHMGLMLTTCSADGVVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSNTAYSGKVQIYEYVENTRKYAKVETLMTVTDPVHDIAFAPNLGRSFHVLAIATKDVRIFKLIPMRKESSSSGPTKLEVQLQAQFDGHNSQVWRVSWNITSTLLASSGDDGCVRLWKANYMDNWKCTGILRGDGSPVNGAAGQAGTPGAAGTPGGPASQNALQAVAGRKKAQLMPG
What is the function of this protein?
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
What are the official names of this protein?
Nucleoporin SEH1, GATOR complex protein SEH1, Nup107-160 subcomplex subunit seh1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC13 family.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex. Lysosome membrane.
Protein: CENPS_XENLA
Sequence: MAEGQEEHFSRTQRLKAAVHYVVGSLCQEVADDKEIDFSKQAIAAISEITFRQCESFAKDLEIFARHAKRTTINMDDVKLLARRSRSLYAHISKCSDEIAANSLEQKEKKKKKSVSGGNVSRNSDMDTVVPESKD
What is the function of this protein?
DNA-binding component of the Fanconi anemia (FA) core complex.  Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage.  In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA.  Stabilizes FANCM.  In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks.  In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression.  As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.  DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded.  Does not bind DNA on its own.
What are the official names of this protein?
Centromere protein S, CENP-S, Apoptosis-inducing TAF9-like domain-containing protein 1 homolog, FANCM-interacting histone fold protein 1.
What is the protein family that this protein belongs to?
Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPS is more stably bound at the kinetochore than CENPX. During S phase, rapidly recruited to DNA interstrand cross-links that block replication. Recruited to DNA damage sites about 20 minutes following UV irradiation, reaching a plateau after approximately 40 minutes.
Protein: TAP46_ARATH
Sequence: MGGLAMEEMPLSVLFEQARKIHLAASESGVDQDVVKKGCEMFQKCEDMIGKLALFSSNETKEDISTNNLKYLLVPYYLAELTEKIIQEDRIQIVKASYAKLKEFFSFCEAMELVPDEELEASSRGGSGAPADRRALKIARFKRQKAAEAKLLEIKERKERRGRSTKASALSTPVESGEDDIPDDDSEEEREAWLSSINLAICKAIDLLEMLKREEEMLSAIKERQLKDGEGGFSRDALDDRTKKAETWHRDAAARIQYSKPAQPITCATFAQDVLEGRASVSQGHEHKNQPLIFGPASIVGGPLSTERERMIAQVFQPSHRMPTMCIEDAGLTEMNIMNDWQEQTKKAIEEATTSWYNDKPLRRKEEDEEDDDEDEEAVMKARAFDDWKDDNPRGAGNKKLTPCG
What is the function of this protein?
Involved in the positive regulation of the TOR signaling pathway (PubMed:21216945, PubMed:25399018).  Acts as a negative regulator of PP2A catalytic activity (PubMed:10517853, PubMed:21216945, PubMed:24357600).  Plays a positive role in the ABA-regulated inhibition of germination, probably throught its interaction with ABI5 (PubMed:24357600).
What are the official names of this protein?
PP2A regulatory subunit TAP46, 2A phosphatase-associated protein of 46 kDa.
What is the protein family that this protein belongs to?
Belongs to the IGBP1/TAP42 family.
Protein: EFTS_CAMC5
Sequence: MEITAQMVKELRESTGAGMMDCKKALSEADGDMQKAVDILREKGLGQAAKKADRLASEGLVSVEVCEHCKRATISEINSETDFVARNPQFQALTKDTTAHIQAKGITSVEELNESTLNGVKFEEYFKTQIATIGENLVVRRFETISADEKGVVNGYVHSNGRVGVLIGAACQSEEVAQKAAEFIRNLCMHAAAMKPTVISYKDLEKDFVEKEFIALKAELEKENEELKRLGKPLHHIPRFASRSQITPEILAGVENEIKEELKAEGKPEKIWDKIIPGKIERFYADNTILDQRLTLLGQFYVMDDKKTIEQVLAEKSKELGGKIEIVKYVRFELGEGLEKKVDDFAAEVAAQIG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIQ_ENCCU
Sequence: MQIFVKTLTGKTITLEVEPSDSIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGY
What is the function of this protein?
Ubiquitin exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Ubiquitin.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ACCA_CHLPD
Sequence: MANRVVLDFEKPLFELEAKLEEMRVYLRNSSRDQDSSDQDVLNREIEALEVKVETLRRSIYKNLTRWQKVQLARHAERPFTLDYIYMMTRDFVEMAGDRYFSDDKAIVGGFAILEDIPSGFSQPVMIIGHQKGRDTKSNLYRNFGMAQPEGYRKALRLMKLAEKFNKPVITLIDTPGAFPGIEAEERGQAEAIARNLFEMARLTVPVICVIVGEGASGGAIGLGVGNRILMAENSWYSVISPESCSSILWRSWNYKEQAAEALQPTAEDLLAQGIIDRIIPEPMGGAHTDPEAMAGTLKEMLIEELRILMSKESDVLVRERVEKFSGMGVWDE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANXA9_MOUSE
Sequence: MSASCGPLGTSLTQEILSSLGLADKTAAWGTLGTLRTFLSFSVDKDVQRLLKAIAGQGVDYDTIVDVLTNRSREQRQLISRAFQERTKQDLLKSLQAALSGNLEKIVVALLQPAAQFDAQELRTALKTSGSAEDVALEILATRAAPGLQACLAVYKHDFQVEAEEDIRTETNGILQDLLLALSKGDRESYSGIIDYNLEEQDVRALQQAGESSTAGQWVLLLTQRSPEHLIRVFDQYRRCTGQELEDAIRNCFHGDAQLALISLASMLRNTALYFANKLHQALQETEPNFQVLTRVLISRSESDLLSIRAEFKKKFGKSLYSSLQDVVRGDCRSALLALCRAEDI
What is the function of this protein?
May act as a low affinity receptor for acetylcholine.
What are the official names of this protein?
Annexin A9, Annexin XXXI, Annexin-31, Annexin-9.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
Protein: FEMA_STAAC
Sequence: MKFTNLTAKEFGAFTDSMPYSHFTQTVGHYELKLAEGYETHLVGIKNNNNEVIAACLLTAVPVMKVFKYFYSNRGPVIDYENQELVHFFFNELSKYVKKHRCLYLHIDPYLPYQYLNHDGEITGNAGNDWFFDKMSNLGFEHTGFHKGFDPVLQIRYHSVLDLKDKTADDIIKNMDGLRKRNTKKVKKNGVKVRFLSEEELPIFRSFMEDTSESKAFADRDDKFYYNRLKYYKDRVLVPLAYINFDEYIKELNEERDILNKDLNKALKDIEKRPENKKAHNKRDNLQQQLDANEQKIEEGKRLQEEHGNELPISAGFFFINPFEVVYYAGGTSNAFRHFAGSYAVQWEMINYALNHGIDRYNFYGVSGKFTEDAEDAGVVKFKKGYNAEIIEYVGDFIKPINKPVYAAYTALKKVKDRIF
What is the function of this protein?
Catalyzes the formation of the pentaglycine interpeptide bridge, which is characteristic of the S. aureus peptidoglycan.  Adds glycines 2 and 3 of the pentaglycine bridge, using glycyl-tRNA(Gly) as donor.  Involved in resistance to methicillin (By similarity).
What are the official names of this protein?
Aminoacyltransferase FemA, Factor essential for expression of methicillin resistance A, N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase.
What is the protein family that this protein belongs to?
Belongs to the FemABX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_ACISJ
Sequence: MTPRPIRHQYEDLMRHVFEHGTAKGDRTGTGTKSVFGHQMRFDLSEGFPLVTTKKVHLKSIILELLWFLRGDSNVRWLQERGCTIWDEWARDDGSLGPVYGVQWRSWPTPDGGHIDQIQQVIDTLKTHPDSRRIIVSAWNVAELDRMALMPCHAFFQFYVAPSQVAGEPGKLSCQLYQRSADIFLGVPFNIASYALLTHMVAQQCDLQVGDFIWTGGDCHIYSNHFEQVRTQLARQPYAYPTLQIKRRPASIFDYAYEDFEVVGYEHHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_ECO5E
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLTIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALVQYRDQLDGKTFCVRVKRRGKHDFSSIDVERYVGGGLNQHIESARVKLTNPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAVKSKIEAEEEKFDFSILDKVVEEANNVDIREIAQQTGQEVVEVETVNDFGPNDVILDIRSVDEQEDKPLKVEGIDVVSLPFYKLSTKFGDLDQNRTWLLWCERGVMSRLQALYLREQGFKNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF146_ASFM2
Sequence: MGGTTDFVLSITIVLVILIIIAFIWYNFTGWSPFKYSKGNTVTFKTPDESSIAYMRFKNCVFTFTDPKGSLHSVDVTNVLNNMAKGFRDAQNPPSSFTLGGHCQAPLNAFSFILPGVNDRATVATADEAKKWENCDATLTGLQRII
What are the official names of this protein?
Uncharacterized protein E146L, pE146L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus E146L family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein. Virion.
Protein: MPIP3_PIG
Sequence: MAEGGRPGSGPSFRSNHRKILNLLLERETSFSMSSDRPGTPLKKKLFGDSANLSILSGGTPKRCLDLSNLSSGEMSATQFTTSADLDETGHLDSTGSEEIQLAGMSYHQHLLKCSPAQLLCSTPNALDHGRRKKDAICSSSENKENENNTSKPLEWWAHRNLLFQKRPGGPYMSPLSLLDNGNLVEGEMKHLGSPITAVSKLDKNPERGEDQAEEISDELMEFSLEDQEEAKVSLNTSCLYRSFSLPDSLNSPGLKQVVKFKDHTLPDKVKKKYCSSHEELRKGLGVKKMVSLCNINMIQMLEEDSNQGPLIGDFSKVCALPTVSGRHQDLKYVNPETVAALLSGKFQGLIEKFYIIDCRYPYEYLGGHIQGALNLYSQEELCNFFLKKPIIPLDTQKRIIVVFHCEFSSERGPRMCRSLREEDRALNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKAELLRCRSQNKAWEGERQLQEQIALLVKDVSP
What is the function of this protein?
Functions as a dosage-dependent inducer in mitotic control.  Tyrosine protein phosphatase required for progression of the cell cycle.  Directly dephosphorylates CDK1 and activates its kinase activity.  When phosphorylated, highly effective in activating G2 cells into prophase (By similarity).
What are the official names of this protein?
M-phase inducer phosphatase 3, Dual specificity phosphatase Cdc25C.
What is the protein family that this protein belongs to?
Belongs to the MPI phosphatase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SEY1_LEIMA
Sequence: MSLHLVDADGHLHSEKRLKEYLTTIVAPSVSQSGSAATADDGDGDSTLEAIGVNYHVVGVFGGQSSGKSTLLNHLFGTDFQTLNEAVRRGQTTKGAFMARANDALAGVEASSAAVVADRLASGAADRSSCLNRAAAAAATKDVADGAHGASRTASLMLVLDFEGTDGLERGEDQCFERQLSLFGLSIADTLIINMWAVDVGRFNAANLNLLRTIFEVNLQLFSHDKYEAEEKPTLLIVLRDFTEDDPAPSLATVRKSFDTIWEGITRPAQFAGASIDALFHLKYYVMPHYKLQKTEFMTSVETLQRWFSDSQCPDYLFSHRAMFRGVPLEGLPAYLTSCWEAIRTSKDLDIPTQREMLAQHRCKEAKMQELKAFRHFARNYEDRLLHGEMLLRLSEVLDEEMETRLTSFYRQTKLYNSDVVGQYANELETELVNATMRVLNRLSKAIAAEVLSNAEPRVLNSVEESLRQLLKSAQTLPFSAGEGPGAAEAAEVNDVEGDAAHLVGAQRMDSPACQKLVRSFWRSLSRHVNEVVAEVAAMPPRAHLYGRYVALIAQDPTTRLNVLNIVTDALFQKVKSRMVSMADSACDTMHAGFERSLTHNSDGTARFFATTKGLQKAVPAATQAGVVVLGSLFYFRLKLVAAADDDGIGADAAGTALPQSRSARRVRQDRHRILFNDNDAEAAFYLSYSTFDTAPKYPYDVPVRSADCDGEEAGAAADCILLSQQATVRAYELYRQKCDFTTQLQLRTIEAGKQRLPAWVIPALFILGWNELLYVLTSPALLVLVVVICAVFFKQFFVSQWHAFEETGPASVVIPTKTVIHTLSTLVRPLLDYGPGPRTERTERSHDAAAAVEEMSHVEATCTHVDPTLGSANLPAAPATMRHRTSRKLD
What is the function of this protein?
Probable GTP-binding protein that may be involved in cell development.
What are the official names of this protein?
Protein SEY1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SC61A_YARLI
Sequence: MAGVRFLDLVKPFTPFLPEVQAPERKVPFNQKIMWTAVTLMIFLVMSEIPLYGINSSDKSDALYWLRMMLASNRGSLMELGITPIVSSGMVFQLLGGTQLIEVNMDLKSDRELYQTAQKLFAIILSLGQATVYVLTGMYGPPKDLGVGVCLLLIFQLVLAALVVILLDELLQKGYGLGSGISLFIATNICEQIFWKAFAPTTVNKGRGYEFEGAIVAFVHLLFTRKDKKRAIIEAFTRQDLPNMSQLVTTVAIFAAVIYLQGFRVDIPVKSSKQRGPYGVFPIKLFYTSNLPIMLQSALTSNIFIISQMLFKKFPTNVLVRLLGVWDGREGMQQLFPVSGIAYYMQPPFNAKEALADPVKTVIYIAFVLGVCAVFSATWIEISGSSPRDVAKQFKEQGLVIAGRRETSAYKELKRIIPTAAAFGGATIGALSVASDLLGALSSGTGILMAVTTIYGYYEMAAKEGYVDAAI
What is the function of this protein?
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER.  It is required for assembly of membrane and secretory proteins and is essential for cell growth.  It interacts with other membrane proteins required for protein translocation.  Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event.  A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
What are the official names of this protein?
Protein transport protein SEC61 subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: Y2165_ARCFU
Sequence: MDARQLHFHLGGCNFLRSALLRHATIQVLGGRRWFQLVQSGLLGMVVGVDNDQGAVFRAGDWWVKDNTNAAKNSMEKNWDPDVDDFGVVDNTNAVNQILRNYEAVFYSGHGNKEGGGYGKGECIVVKGTGKHPELWYCYHHAVYGLRTRLFVIQACYAANENPNSLANVLARKGVECVIGASGSIHDYDAFGLPTCRTWADVFWDHVTGNSDANYQKRTAHEARIEANSAAWFCDLDREVGNCNMYI
What are the official names of this protein?
Uncharacterized protein AF_2165.
Protein: SYL_CORJK
Sequence: MTNGSTEDNSYRYTPGLAAKIEAKWQKHWADKGTFNAPNPTGDLAEPGAELPEDRKFIQDMFPYPSGVGLHVGHPLGYIGTDVFARFHRMKGANVLHTLGYDAFGLPAEQYAVQTGTHPRTTTMANIANMERQLGRLGLGHDKRRSFATTDTDYYRWTQWIFLQIYNSWFDPEAKNANGTLGKARPIKELEEKLAAERADWADLSAAEKQEILDSYRLVYRSNSTVNWCPGLGTVLANEEVTAEGRSERGNFPVFRKNLQQWMMRITAYSDRLIDDLEYLDWPEKVKSMQRNWIGRSRGAEVTFDCLGNDIDVFTTRPDTLFGATYMVLAPEHELVDTLVAQSGNSSSGSDAYTDVDPRWTYGQANPAAAVEAYRAAIAAKSDLERQENKEKTGVFLGVYATNPVNGAQVPVFIADYVLTGYGTGAIMAVPAHDSRDFEFATEFGLPIVPVLAPEGAEAGAGEQGGAELTEAFTEDGPHINSNNSDGLELNGLGKAEAIDKAIEWLESKGVGSGKIQYKLRDWLFARQRYWGEPFPIVYDEDGTAHGLPEDMLPVELPEVEDYKPVSFDPDDKDSAPQPPLAKAKDWVEVTLDLGDGEKTYYRDTNVMPQWAGSSWYQLRYIDPNNDNALVDIENERYWVGPREGRPSGGVDLYVGGVEHAVLHLLYARFWHKVLFDLGVVSSFEPYYRLYNQGYIQAYAYTDSRGVYVPAEEVTERDGKFFWVRKADDAEGVTKEEEVFQEYGKMGKSLKNAVSPDEICDDYGADTLRVYEMAMGPLDTSRPWATKDVVGAQRFLQRAWRLAVDENTGKGSVSDDALTDEDLKALHRTIAGVHENYAELRDNTAVAKLIEYVNYLTKTYSAGQAPRAAVEPLVQMLSPVAPHIAEEMWEILGHSEGITYESFPEWDEKWLVDDTIELPVQVMGKLRGRINVAADASREDIEAAALEEPNVASHIEGKTVAKIIVVPGKMVNIVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_VESOH
Sequence: MAIEGLIKQGFVTMSLDRVINWARTGSLWPMTFGLACCAVEMMEAGSSRYDLDRFGIVFRPTPRQSDLMIVAGTLTNKMAPALRKVYDQMPEPKWVISMGSCANGGGYYHYSYAVIRGCDRIVPVDIYVPGCPPTAEALLYGIMQLQDKIRRTNTIART
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS12_NOSS1
Sequence: MPTIQQLIRTEREKARQKTKSPALKQCPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGTLDTAGVKDRKQGRSKYGTKRPKEAKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RPOZ_RICCN
Sequence: MARITAEDCNKIIPDRFRLVVLATRYAKLLNYKVETNQIKKEKRDKPPVIALRRIAAGKVSVAQLEQDLINSLRTRTMIEPLVNQDESEAVEEKFEYLPEVYIGEDYSDLDDQIFIDENGEDYETDK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.