PharMolix/UniProtQA huggingface dataset:
Protein: KUP_BURP0
Sequence: MTDTNHSSMRQHSLQSLAIAAIGVVFGDIGTSPLYSLKEAFSPAHGIPLTPSAILGVISLLFWAIILVVGIKYVLFVMRADNNGEGGVLALMALSLRPLNPKSRITGLMMALGIFGACMFYGDAVITPAISVMSAVEGLEVATPQLSHLVLPITIVILIALFWIQRHGTATVGKLFGPIMVLWFVTIAALGIYHIARAPMIVSAINPYYAFSFMSEHVLLAYVVLGSVVLVLTGAEALYADMGHFGAKPIRLAAYVLVMPSLVLNYFGQGALLLLDPKAIENPFFLLAPQWAALPLVVLSTVATVIASQAVISGAYSLTSQAIQLGYVPRMKILHTSELAIGQIYVPVVNWLLLFVILCIVIGFKSSDNLAAAYGIAVTATMVITTILAAVVMVKVWNWNKLLVAMIIGVFLVIDLGFFGANLLKVEQGGWLPLGIGALLFFLLMTWYKGRHIVKERTAADGIPLAPFLQGLLAHPPHRVSGTAIYLTGNDTLVPVSLLHNLKHNKVLHERTIFMTFVTRDIPYVKDHERVTVHDAGEGLYIVKAEYGFNETPDVKAVLEEVARQRGMTFELMDTSFFLARETVVPTHLPGMSIWRERVFAWMHQNAAKPTDFFAIPANRVVELGTKIEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRUD_XANCP
Sequence: MSDSPVLPRAHGAAVLTAAMRSVAEDFQVDELPAFDASGEGEHLLLTVRKRGQNTAYVAKRLAQWAGIAEMGIGYAGLKDRHAVTTQRFSVHLPKRIAPDLSALDDDDMQVVEHTWHNRKLQRGALHGNRFVLTLREVVGDQAVIDARLHAIAARGIPNWFGEQRFGRDGGNVAAALAMFGHTRQPDGTLAPAPKRRLRNDQRSLLLSAARSALFNQVLTARVEQGNWDAPLDGEAWMLDGSRSVFGPEPWSEVLAERLARFDIHPSGPLWGAGELRCSADAAAIEQAALSDPQSLALRTGLEAAGLKQERRALRLRPQGLAHAWLDAQTLQLTFALPPGCYATAVLWELGEVVDAARVAPQSRSEG
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: PYRB_PSYT1
Sequence: MPNTHDTKNNVSPSEYAKFDPSTIHQRLNTSLSRPQLNSDGSIRHFLGVEGLNKAQLQAIIAKALFFEPSTRTRTTFEVAEKRLGANVLNLDIASSSAKKGESLRDTLWNLQAMTADIFVVRHSASGAAHFMATEVTPDIAIINGGDGWHAHPTQGMLDMLTIHREAPRPFEELSVAIIGDVKHSRVARSDISALQTLGVKDIRVIAPRTLLPKGIERFGVQVYEDMNSCVRDCDVIMGLRIQNERIGSPLLASSSEYYKQYGITPERVALAKPDALIMHPGPMNRGVEIASSVADGPQSVILKQVSNGVAIRMAVLALTMEGQRAHQANRG
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: APAF_DANRE
Sequence: MEERARSRLLRSKATLEQDIKASYLMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNALIRESYGDLASLLHSDLPLLSPEGEKSFADGVSPSVQAILSVGGVPQRPVVFVSRPPLLNLIREMLYQLRDTPGWVTVFGMAGSGKSVMAAEVVRDRSLIKECFPDGVHWLSVGQCERADLLVRMQSLCFRLEQCQSSDTSQRPPSTVEEAKERLRFLMLRRFPRSLLILDDVWDSSSLRSFDIQCRVLLTTRNRALTDSVSGVRYEVPVENGLDEEKALEILALYVNGKMHKLPEQARSIVSECKGSPLVVSLIGALLREFPDRWSYYLRQLQQKQFKRIRKSSSYDYEALDQAMDASLQVLEAEHQELYRDLSVMQKDIKVPAKVLSVLWGLELEEVEDVLQEFVNKSLLFRDCNQRPYRYYLHDLQLDFLAEQNRDQIAELHKKMVRQYQRFYSKRPPDSADKDSLYWYQFIPYHMAKAGLSKELYSLMFSLDWVKEKARIMGSAHLINDYVEYGEILDKENSEVRVQFQEFLSLNGHHLEQRPFPDVVQLALSQPDRSEVYRQALMQAQKRASRGQIYLNWVNKNIEEGLSRLVMHPHQGAVYYACFSKDGSKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSPDDRHIATCASDRKVKLWNVERGVLIREFEVEHEEQINHCQFTNTGRRVLLATCSNDKFTNTRLWNPNKKTSQNTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKLFEVSSANEWKSIDVDSFFPESDEEIKAMVKCSTWSADGSQIICAARNTVFVFDVETSDLLLKLKTSRLSTIQFCHACPNSSLLAVALSHYTVELWNFESSKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWETDRVHTSSAVALKRDTDVLSSHSDATIIAPDSSNRLQVLSGSTGAVVLESEELSSRIRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRTGECMVLQGHMEPVRKFHLLSSSSSPHLFSWSFDGTVKVWDLTRGQMLQDLVCHEGAVLSCDVSSDGRLFATTSANRTAKVWSSASWKMLFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIRLWSMLDGALLKICPRDTKDSMNSYHAGWVTDLHFSPDNRVLVSTAGYIKWWSVESGEALQTFYTMGGNLKKIHVSPDFSTFITVDSIGILYILKRLEGEGT
What is the function of this protein?
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis.  This activation requires ATP (By similarity).
What are the official names of this protein?
Apoptotic protease-activating factor 1, APAF-1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRAF6_CERAT
Sequence: MSLLNCENSCGSSQSESDCCVAMASSCSAATKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALVDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAALVAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSLIPDSGYVSEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSTYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPDLLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDSGV
What is the function of this protein?
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2.  Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.  Leads to the activation of NF-kappa-B and JUN (By similarity).  Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity).  Represses c-Myb-mediated transactivation, in B-lymphocytes.  Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity).  Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.  Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity).  Participates also in the TCR signaling by ubiquitinating LAT (By similarity).
What are the official names of this protein?
TNF receptor-associated factor 6, E3 ubiquitin-protein ligase TRAF6, RING-type E3 ubiquitin transferase TRAF6.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family. A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet. Note=RSAD2/viperin recruits it to the lipid droplet.
Protein: RECJ_METJA
Sequence: MENWVELKKGAKVLQNNKNNKILIVTHIDTDGLTSRAILQKLAERLNLDADFMFLKQITIETINDIPFKDYDLIIFADLGSGQLKMIKEKLDELNLSDKRDKIIILDHHQPEEIKIPKTIIHINPLTIAKSGAEICGAGVSYLFAKAINNDWIDLAKYAVLGAVGDIQNIEGKLIGLNRKILCDAIMNGDVKVKTDLQMYGRQTRPLFVSMRYWADVRTDLLNNDSKIIKYIQSINKKYDIEINPTMRLAEIPFEHKRIIGNELLIKCLNYVPNHWTPYIPKVIFGEVYEFRGEEFGSPLRDLEEFSTCINACSRYGDYETALNVLMGDRDKYYRKMLSNLRKHRNNLREALEHVKNDVEIIQKDRFQYFETDKIMSNIVGIVAGMSYSIEEVDWMKPIFAITEDENGYKVSARCPKLLCFAEDVNLAKAIKYASEKVNGSGGGHKFACGAYIPDNKREFIKYLEIALR
What is the function of this protein?
Single-stranded-DNA-specific exonuclease.
What are the official names of this protein?
Single-stranded-DNA-specific exonuclease RecJ.
What is the protein family that this protein belongs to?
Belongs to the RecJ family.
Protein: SYL_BRUC2
Sequence: MAAERYNPRVAEAHWQKVWEENRTFETDNSDSREKYYVLEMFPYPSGRIHMGHVRNYAMGDVVARYKRAKGFNVLHPMGWDAFGMPAENAAMQNKVHPKEWTYQNIATMKRQLKSMGLSLDWSREFATCDVEYYHRQQMLFIDLYEKGLVTRKTSKVNWDPVDNTVLANEQVVDGRGWRSGALVEQRELTQWFFKITDFSEELLAGLDTLDQWPEKVRLMQRNWIGKSEGLQVRLALAAGTAPAGFSEVEVYTTRPDTLFGAAFVAISADHPLAKKLSEGNAALSSFIEECHQQGTSLAALETAEKKGFDTGIKVKHPFDDNWELPVYVANFVLMEYGTGAVFGCPAHDQRDLDFANKYKLKVTPVVLPKGEDAASFSIGETAYTDDGVMINSRFLDGMTPAAAFNEVASRLEKTDLVGRPQAVRKVQFRLRDWGISRQRYWGCPIPMIHCESCGVNPVPRADLPVKLPDDVEFDRPGNPLDRHATWRHVKCPKCGGDARRETDTMDTFVDSSWYYTRFTAPWENEPTDRKAADHWLPVDQYIGGIEHAILHLLYSRFFTRAMKVAGHVGVDEPFKGLFTQGMVVHETYKANGQWVSPADIRIEEIDGKRVATMLDSGAPVEIGSIEKMSKSKKNVVDPDDIIASYGADIARWFVLSDSPPERDVIWTEAGAEGAHRFVQRIWRLVAEAAPALKDVAPKAGTQGEALGVSKAAHKAVKAVGDDIEKLAFNRGVARLYELVNTLSGALQQAADGKADAEMKGALREATEMLVLMTAPMMPHLAEQCLAELGGKVAGKETLVARAPWPVFDPALVVENEIVLPVQINGKKRGDLTIARDADQASIQQAVLELDFVKAALNGGSPKKIIVVPQRIVNVVA
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YRDD_ECOLI
Sequence: MAKSALFTVRNNESCPKCGAELVIRSGKHGPFLGCSQYPACDYVRPLKSSADGHIVKVLEGQVCPACGANLVLRQGRFGMFIGCINYPECEHTELIDKPDETAITCPQCRTGHLVQRRSRYGKTFHSCDRYPECQFAINFKPIAGECPECHYPLLIEKKTAQGVKHFCASKQCGKPVSAE
What are the official names of this protein?
Uncharacterized protein YrdD.
What is the protein family that this protein belongs to?
To H.influenzae HI_0656.1.
Protein: 5DNU_PASMU
Sequence: MKISHFFACLDRLRLIQRWSLMRNIEKENLAEHSLQVAFVAHALAVIKNKFYQGHLNPDRIAVMAMYHDTSEIFTGDLPTPIKYFNPKITQAYKEIENAAEAHLLALLPKELQADFAPYLDSTQFSAQEKHVVKQADLICAYVKAQFELENGNQEFKAAKARLETLMKTWHSDEMRYFIEVFIPSFGKPIDEITL
What is the function of this protein?
Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
What are the official names of this protein?
5'-deoxynucleotidase PM0747, 5'-deoxyribonucleotidase, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the 5DNU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VME1_CVBOK
Sequence: MSSVTTPAPVYTWTADEAIKFLKEWNFSLGIILLFITVILQFGYTSRSMFVYVIKMIILWLMWPLTIILTIFNCVYALNNVYLGFSIVFTIVAIIMWIVYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGRMYVRPIIEDYHTLTVTIIRGHLYMQGIKLGTGYSLSDLPAYVTVAKVSHLLTYKRGFLDKIGDTSGFAVYVKSKVGNYRLPSTQKGSGMDTALLRNNI
What is the function of this protein?
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
What are the official names of this protein?
Membrane protein, M protein, E1 glycoprotein, Matrix glycoprotein, Membrane glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses M protein family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer.
Protein: RRP42_METAR
Sequence: MSEDVIAEIKRDYIYSLANQGDRADGRKFDEFRAISVETGVINKAEGSARVKIGDSQVVVGVKIQPGEPFPDTPDSGVIITNLELVPLASPTFESGPPREDAIELARVVDRGVRESGAIDLSKLCIESGQKVWMVFIDVHVLDHDGNLMDAASLGAIAALKATKIPNSKFGLGEDVKLPLNDVPIGVTAVNIGGAIMLDPSLDEESVAPCKLTVITNKEGAISGMQKSGVGTLTPDQINHIIRLAKEKANVLREKLEGIQ
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Contributes to the structuring of the Rrp41 active site.
What are the official names of this protein?
Exosome complex component Rrp42.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family. Rrp42 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1A1D_AGRVS
Sequence: MLDAFDRYPLTFGPTPIEKLERLTDHLGGKVQLYAKREDCNSGLAFGGNKLRKLEYIIPDAIASGADTLVSIGGVQSNHTRMVAAVAAKIGFKCRLVQEAWVPHEDAVYDRVGNIMLSRIMGADVRLVDDGFDIGIRRSWEEAIEEVKAAGGKPYAIPAGASVHKYGGLGYVGFAEEVRAQEAALGFAFDYIVVCTVTGSSHAGMAVGFAKDGRADHVIGIDASFTPDQTRAQVLEIAQRTADLVKLGREMRPEDIVLVEDYAYPVYGVPSEETKDAIRLVGRLEGMITDPVYEGKSMQGMIDLVKKGYFPEGSKVLYAHLGGAPALNGYGYAFRNG
What is the function of this protein?
Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate.  Allows growth on ACC as a nitrogen source.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate deaminase, ACC deaminase, ACCD.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: RL13_PSEPG
Sequence: MKTFTAKPETVKREWFVVDAAGQTLGRLATEIATRLRGKHKPEYTPHVDTGDYIVVINAEQVRVTGAKSSDKMYYSHSGFPGGIKEINFEKLIAKAPERVIETAVKGMLPKNPLGRDMYRKLKVYAGAAHPHTAQQPQELKI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ATPE_BURP1
Sequence: MATIKVDVVSAEEQIFSGQAKFVALPGEAGELGILPGHTPLITRIRPGAVRIESESGDEEFVFVAGGILEVQPGAVTVLADTAIRGKDLDAAKAEEARKRAEETLQNAKSDIDLAKAQSELATAMAQLEAIQRLAKIRGKH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HIS4_ACIC1
Sequence: MTGLEILPAVDVAGGQAVRLVQGAAGTETRYGSPLEAALAWQAAGARWIHLVDLDAAFGRGSNRELLAEIVARVDVAVELSGGIRDDESLRVALATGCARVNIGTAALENPEWVRRVVAEYGEKIAVGLDVRDGRLAARGWTKDGGELFEVLARLDADGCARYVVTDVARDGTLGGPNIELLRAVCAATDRPVVASGGISSLDDVRAVAALVPLGVEGLIIGKALYAGVFSLREAMTAAQA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNA_XYLFM
Sequence: MHHPLPPDDTLYDQVRPILWTGYFLKLLDQRKLPFVVEYVECHSSEDVTQAIRTLIVRGAPAIGIVAGWGAVLAAREIEAVDGIEALRKLEPALQRLHAARPTAVNLAWVLARMRRTLSAAHADWRQVMECEAESIAREDITANRCMGAYGAALIPIGSGVLTHCNTGSLATAGFGTALGVIRAGIAQGRIARVFAGETRPWLQGARLTVWELQQDGIDATLIADSAAAHLMKSGQVQWVIVGADRICANGDTANKIGTYQLAITARHHGVKFMVVASAATVDMDTTAGEAIEIEQRDPEELLGVSGVRTVAEGIAAWNPVFDVTPGALIDAIVTERGVIQSPDAAQMRATFSN
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: VATB1_HUMAN
Sequence: MAMEIDSRPGGLPGSSCNLGAAREHMQAVTRNYITHPRVTYRTVCSVNGPLVVLDRVKFAQYAEIVHFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDARKTTCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPVVMAEDFLDINGQPINPHSRIYPEEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKAVLDYHDDNFAIVFAAMGVNMETARFFKSDFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRGGSITQIPILTMPNDDITHPIPDLTGFITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYACYAIGKDVQAMKAVVGEEALTSEDLLYLEFLQKFEKNFINQGPYENRSVFESLDLGWKLLRIFPKEMLKRIPQAVIDEFYSREGALQDLAPDTAL
What is the function of this protein?
Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:16769747).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091).  Essential for the proper assembly and activity of V-ATPase (PubMed:16769747).  In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification (PubMed:16769747).  Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit B, kidney isoform, V-ATPase subunit B 1, Endomembrane proton pump 58 kDa subunit, Vacuolar proton pump subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Apical cell membrane. Basolateral cell membrane.
Protein: PDK2_YEAST
Sequence: MSKYQINCIRYRHFLRTSNISQIPDFTKYCIGPVNEELAPYIMETMKAYPSNSEYINPQHYYHNRTVLVENYLKRSPNPVSLTQLAQYYDDSTKLTRTKIINSGKFVKEELVIRIAHKLNQLQQLPFNVVNNFHFVQVYESYYNIFESFRKYPTIRTLEDASQFADFIKNMLEGFNTLNLPHLIMGALECTILDLYPREKMDQLLSDLLRARISRRLIVEEHVSITANYTSGKEENTLVLGDIFQECSAKKYLLEASEESQKFIQDMYFKDIPMPEFIIEGDTQLSFYFLPTHLKYLLGEILRNTYEATMKHYIRKGLEKPEPIIVTVVSNDESYLFRISDKAGGVLHDDENLWSFGKSKERAQESLNNFHKLPGLQTVSIYDEVHSHTKYNSKLKSLQSITLKPYMHTSLEPMSYPSIINGHIKYETPLIELLKRSFRYKLGIGLAMCKVYAEYWNGDLSLHSMPGYGTDVVLKLGNLMKHTKKLQLDKV
What is the function of this protein?
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism.
What are the official names of this protein?
[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial, PDK 2, Pyruvate dehydrogenase kinase 2, Protein kinase of PDH protein 2, Pyruvate dehydrogenase complex kinase 2, PDC kinase 2, [Pyruvate dehydrogenase [lipoamide]] kinase 2.
What is the protein family that this protein belongs to?
Belongs to the PDK/BCKDK protein kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RAC1C_DICDI
Sequence: MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIISPSSYENVSGKWGPEVFHHAPNVPIILVGTKMDMREDKETQDRLKEKKLYPVSYEQGLLKMKEINAFKYLECSALTQKGLKTVFDEAIRSVINPPVKKSKSKSGCNIL
What is the function of this protein?
Overexpression promotes the formation of filopodia and membrane ruffles.
What are the official names of this protein?
Rho-related protein rac1C.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: FOLD_RHORT
Sequence: MGAHLIDGKAIAQQLRERIAQEVADLKAHRGLVPGLAVVLVGEDAASQVYVGSKEKMAVAVGMHSVVCRLAATTSEAEVLAKVEALNADPTIDGILVQLPLPAHIDEDKILLAIDPDKDVDGFHPVNVGRLSIGQSNGEHGMVPCTPKGCLMLLKGVLGDLTGKTALVIGRSNIVGKPMAQLLLSANCTVTLAHSRSRDLPDLCRRMDIVVAAVGRPEMVKGDWLKPGAVVIDVGMNRLPAAPGAEKGKLVGDVDYASAAAVAGAITPVPGGVGPMTIACLLANTLEACKARGAGA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: MURA_ZYMMO
Sequence: MDRIKIRGGHRLKGRIPVSGAKNAVLALMPASLLTSDSLTLINLPRLADVDSCCHLLNELGVSTMVARSKGDHPGREITLTADTIASTVAPYDIVRKMRASILVLGPLLAREGEATVSLPGGCAIGNRPIDLHLRALEALGAEIELTAGYVRARAPDGGLRGGIISFPVVSVGATENAIMAAVLARGETVINNAAREPEIVDLCQCLMAMGAKIDGVGNSRLVIHGCDRLHGATHVVMPDRIEAGSYACAAAITGGDVLLQGARSADMAEVLVELKESGLNISVEEDGIRVQADAPLKGLTLSTAPFPGFPTDMQAQFMAMLALAQGTSVLTETIFENRYMHVPELVRMGADIQVKGRVAVVKGVSGLVGAEVMATDLRASMSLIIAALAAEGETQVHRVYHLDRGYERLEEKLSAVGADIERVGG
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_RHOPA
Sequence: MANVVVVGAQWGDEGKGKIVDWLSEQADIVVRFQGGHNAGHTLVINGQTYKLALLPSGVLRPSKLAVIGNGVVFDPQAFLDEVKKLQGQGVAISPENLRIAENVTLILPLHRELDATRENAAKAGAIGTTQRGIGPAYEDKVGRRAIRLMDLADLDTLPTKIERLLAHHNALRRGLDQPEIDAGQILADLSAMAPHLLPYAESVWRLLDIKRREGKRILFEGAQGALLDVDHGTYPYVTSSNTVAAQAATGTGMGPGAVGYVLGICKAYTTRVGAGPFPTELTNEIGEEIGRRGKEFGVNTGRKRRCGWFDAVLVRQTVRTCGIHGLALTKLDILDGFDSVEVCVGYKLDGKEIDYLPAGEGAQARVEPIYETIEGWKEPTANARSWAELPAQAIKYVRRIEELVGCPVALLSTSPEREDTILVQNPFEA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INHA_MOUSE
Sequence: MVSQRSLLLLLLLTLRDVDSCQGPELVRELVLAKVKALFLDALGPPAMDGEGGDPGIRRLPRRHAVGGFMHRTSEPEEEDVSQAILFPATGATCEDQPAARGLAQEAEEGLFTYVFRPSQHIRSHQVTSAQLWFHTGLGRKSTAAANSSAPLLDLLVLSSGGPMAVPVSLGQGPPRWAVLHLAASAFPLLTHPILVLLLRCPLCSCSGRPETTPFLVAHTRARAPSAGERARRSTPSVPWPWSPAALRLLQRPPEEPAAHAFCHRAALNISFQELGWDRWIVHPPSFIFHYCHGSCGMPTSDLPLPVPGVPPTPVQPLFLVPGAKPCCAALPGSMRSLRVRTTSDGGYSFKYEMVPNLITQHCACI
What is the function of this protein?
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.  Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.  Inhibins appear to oppose the functions of activins.  Inhibin deficient mice are viable but are acutely sensitive to development of gonadal sex-cord stromal tumors.
What are the official names of this protein?
Inhibin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: HELS_HALS3
Sequence: MRVADVPGLPGGVADHFEGEGVEELYPPQAEAVERGVTEGANLVASVPTASGKTLIAQLAMLSAIAEGGDSPTFSGDGTALYIVPLRALAGEKAQEFEAFERFGLSVGVSTGNYERDGARLADNDIVVATSEKVDSLVRNGAGWIDDLSCVVADEVHLVDDDHRGPTLEVTLAKLRQQVADLQVVALSATVGNAGELAAWLDAELVDSDWRPIELRTGVHYGQSLHYDDGTQAELSVGSGSQTAAVVADTLADDGSTLVFVNSRRNAEASARRLADVTGNALSSAERERLADIAAEIRGVSDTETSDELADAVASGAAFHHAGLAREHRELVEEAFRDRLVKAVSATPTLAAGVNTPARRVVVRDWQRYDGTAGGMQPLDVLEVHQMFGRAGRPGLDPYGEAVLLANSHDELEELFDRYVYADPEPVRSKLAAEPALRTHVLAAIATGFTTTEDGLHEFLGGTLYATQTDDTGRLRSVTGDVLRYLDRNGFVERDGAALRATATGQLVSRLYVDPMSAATIIDGLRDAARDATETDDEGAFRPASELGDDAALPADASVEPTPLGLYHLVSRTPDMYELYLRSGDREQYTEVAYEHEDELLGATPREEQAEFEDWLSALKTARLMADWASELDEERIAERYDVGPGDIRGKVETAEWLLNAAERLAGELDVECGPAVREARKRVQYGVREELLGLAGVRNVGRKRARRLYNAGVESRADLRNADKGVVLGAVRGRAATAERILETVGHPDPGMDGVAADTDAAPESGGEAGGDEGQASLGDFS
What is the function of this protein?
DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
What are the official names of this protein?
ATP-dependent DNA helicase Hel308.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Hel308 subfamily.
Protein: TRM1_THEVO
Sequence: MRITEGSAVIEVPEAYSGPGRRSPGFYNADQVLNRDLTIDLINEFGVEKVLDGFGGSGVRGIRISLETKAKVVIAEISPSSCEIIKQNIAINNAEADLIHDNFQCVSSHIAFDYIDVDPYGSPVPYLDAAIMNVRKGGYLGITATDQSTLTGSTLNKTRRRYGAYIVNDIYRHEMGIRTLIGYIARRAAAFDRYIEPQLSIWNHHYYRVFVKVGKGVNGADKMIENIGYLNKHTTIDNSFKDVNEGPVWLSNLNNAELLEKIRDPRVSKKIEMIKHDNRLLFVDLTDIARKTSLSLPPLAKVMDEIMKHGYEAHRTSFSPTGIKTDCPYAEVSEILKAYAKR
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.