PharMolix/UniProtQA huggingface dataset:
Protein: HEM3_MYCBO
Sequence: MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGARELMWGVRH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: FADA_PSEA7
Sequence: MSLNPRDVVIVDFGRTPMGRSKGGMHRNTRAETMSAHLISKLLERNPKVDPAEVEDVIWGCVNQTLEQGWNIARMASLMTQIPHTSAAQTVSRLCGSSMSALHTAAQAIQTGNGDVFVIGGVEHMGHVGMMHGVDPNPHLSLYAAKASGMMGLTAEMLGKMHGISREAQDKFGARSHQLAWKATQEGKFKDEIIPMEGYDENGFLKVFDFDETIRPETTVETLAQLKPAFNPKGGTVTAGTSSQITDGASCMIVMSAQRAQDLGIQPMAVIRSMAVAGVDPAIMGYGPVPSTNKALKRAGLTIADIDFVELNEAFAAQALPVLKDLKLLDKMDEKVNLHGGAIALGHPFGCSGARISGTLLNVMKQNGGTLGVSTMCVGLGQGITTVFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXJ_NOSP7
Sequence: MPTLGVNIDHIATIRQARRTVEPDPVAAAVLAELAGADGITVHLREDRRHIQDRDVRILRQTVRSHLNLEMAATEEMLAIALDIKPDYVTLVPEKREEVTTEGGLDIIGQIARIGEIVDKLQSASIPVSLFIDAEPAQIEASVKVQAQFIELHTGQYAEAKDETNRHRELAILAKGCQQAIQAGLRVNAGHGLTYWNVYPVAALPGMEELNIGHTIISRAALVGIERAVREMKQAIRGNGA
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTH_GRABC
Sequence: MTQITPTCAPPPGPTITDRTSLRLSKAIAGKSRGWKTGLLFAGPAVIASIAYVDPGNFATNIQAGSRYGYTLLWVVAAANLIAMLFQALSAKLGIATGRNLPELCRDHFSRPLVIALWIISEIAAMATDLAEFLGGAIGLALLFRLPLIIGMVATAMITFALLLFEKRGYRVMELVIGALVATIGLCYLAEMFIAPVDWTAAAWATITPRLPDATALTIATGIVGATVMPHAVYLHSGLAQNRAAAATDDASRHRLIRFSNREVILALALAGMVNMAMVIMAASAFHIGHSDVAEIEQAYHTLTPLLGAAAAAIFLISLITSGISSSVVGTMAGQMIMQGFVHIRIPVWLRRLVTMVPAFIVILAGVNATDALVISQVILSIALPAPMIALIYFSGHRELMGPFVNHRVTQWVASAAAAIVLGLNMVLLIQAFGFTIPGLPVAP
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL10_MARMM
Sequence: MDRIQKEASVEELNGIFSEAGSVVMAHYNGMTVAEMTELRAKLRELGGTFKVVRNRLAKIALQGKPGEGAADLFTGPVAIAYSEDFVAAPKVLVEYAKSNDKLVILGGFMEEDVFDAAGIDALSKMPSREELIATISARLMGQASQVAQRLMAPAQGLAGAIDVIREKADA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RS11_ENT38
Sequence: MAKAPVRARKRVRKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCAEAVKEYGIKNLEVMVKGPGPGRESTVRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: HYPE_BRADU
Sequence: MKAYQRKLDIRNGCVDLSHGSGGRAMAQLISGLFHEAFGNEWLARGNDQSAFDVRAGRMVMTTDGYVVSPLFFPGGNIGSLAVHGTVNDIAMAGAKPLYLSASFIIEEGFRFADLKLIAESMGAAAREADVHIITGDTKVVERGKADGLFISTAGVGVVPDGLDLSAEKARVGDRVLISGTLGDHGVAIMSKRQNLAFETEIVSDSASLHDLVARMVQAGGRGIRLMRDPTRGGLAATLNEIAQQSNLGFHLLEEAIPVKPGVAAACELLGLDPLHVANEGKLVAIVAPEAAGAVLAAMRAHPLGRDAADIGEAVADDHHFVQMATSFGGGRIVDWLSGEQLPRIC
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Along with HypF, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases.  HypE catalyzes the ATP-dependent dehydration of the carboxamido group attached to its C-terminal cysteine to a cyano group.
What are the official names of this protein?
Carbamoyl dehydratase HypE, Hydrogenase maturation factor HypE.
What is the protein family that this protein belongs to?
Belongs to the HypE family.
Protein: Y3043_SHEB8
Sequence: MSAVTLQQGDLLLNLYIQPKASRDQIVGLHGDELKVAITAPPIDGKANAHLSKYLAKTFKVPKSDIHIMKGELGRHKQIRVIDPKIIPSIITELMGQTS
What are the official names of this protein?
UPF0235 protein Shew185_3043.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: B2MG_PONPY
Sequence: MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
What is the function of this protein?
Component of the class I major histocompatibility complex (MHC).  Involved in the presentation of peptide antigens to the immune system (By similarity).
What are the official names of this protein?
Beta-2-microglobulin.
What is the protein family that this protein belongs to?
Belongs to the beta-2-microglobulin family.
Protein: CCB21_ARATH
Sequence: MVNSCENKIFVKPTSTTILQDETRSRKFGQEMKREKRRVLRVINQNLAGARVYPCVVNKRGSLLSNKQEEEEGCQKKKFDSLRPSVTRSGVEEETNKKLKPSVPSANDFGDCIFIDEEEATLDLPMPMSLEKPYIEADPMEEVEMEDVTVEEPIVDIDVLDSKNSLAAVEYVQDLYAFYRTMERFSCVPVDYMMQQIDLNEKMRAILIDWLIEVHDKFDLINETLFLTVNLIDRFLSKQNVMRKKLQLVGLVALLLACKYEEVSVPVVEDLVLISDKAYTRNDVLEMEKTMLSTLQFNISLPTQYPFLKRFLKAAQADKKCEVLASFLIELALVEYEMLRFPPSLLAATSVYTAQCTLDGSRKWNSTCEFHCHYSEDQLMECSRKLVSLHQRAATGNLTGVYRKYSTSKFGYIAKCEAAHFLVSESHHS
What are the official names of this protein?
Cyclin-B2-1, Cyc2a-At, Cyclin-2a, G2/mitotic-specific cyclin-B2-1, CycB2;1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
Protein: RL9_CLOD6
Sequence: MKVILLKDVKGTGKKGEMKEVSDGYARNFLFPKKMAVQADSVAIKELNEKNKSKEIKAQKEYEEAVLLGKQMEEINIEIYSKAGEGGRLFGSITSKEIAEQLKKQKDIDVDKRKILLDEPIRSLGSTFVEIKIHQKVTTKIRVDVKEKQ
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: PROF_FRAAN
Sequence: MSWQTYVDDHLMCEIEGNHLSAAAIIGQDGSVWAQSATFPQLKPEEVTGIVRDFDEPGTLAPTGLYLGGTKYMVIQGEPGAVIRGKKGPGGVTVKKTTLALLIGIYDEPMTPGQCNMIVERLGDYLVEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: HCAD_ECOLU
Sequence: MKEKTIIIVGGGQAAAMAAASLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQQVLPANWWQENNVHLHSGVTIKSLGRDTRELVLTNGESWQWDQLFMATGAAARPLPLLDALGERCFTLRHADDAARLREVLQPERSVVIVGAGTIGLELAASATQRGCKVTVIELAATVMGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHVVDGEKVELTLQSGETLQADVVIYGIGISANDQLAREANLDTANGIVIDEACRTCDPAIFAGGDVAITRLDNGALHRCESWENANNQAQIAAAAMLGLPLPRLPPPWFWSDQYSDNLQFIGDMHGDDWICRGNPETQKAIWFNLQNGVLIGAVTLNQGREIRPIRKWIQSGKTFNAKLLTDEDIALKSL
What is the function of this protein?
Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.
What are the official names of this protein?
3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family.
Protein: RNPA_ACIC1
Sequence: MLPSRYRLRRSSDFKAVLRRGRRVAGRYIVVYLSTSDTDRPGPQAGFVVGRNVGGAVVRNRIRRRLRHIVAARLAVIPARKRIVVRALPAAAAASFAELAAEFDRLLGRLTQTKNSQGTS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: YOAH_SALA4
Sequence: MFAGLPSLSHEQQQKAVERIQELMSQGMSSGEAIAQVAGELRANHTGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: RSMH_ANAD2
Sequence: MSADFRHEPVLANEILELLRPRPGELFLDGTLGGGGHSGLLLEAGARVIALDKDPRALAAATARLARFGEAFRAVRSDFRDAKNVLEALGIAAVDGALVDLGVSSPQLDEAERGFSFSRPGPLDMRMGDTGETLEDLLRRIDERELARILREYGEEPFARPVARAVKAALETEAPLDTARLAEVVAGAIPRKAWPHRIHPATRTFQALRIAVNDELGALAAWLDGLPGVLAPGGRAAAISFHSLEDRMVKEKFRALTQACTCPPDLPVCACGAKASFAAITRKAVKASDEEIARNPRARSARLRAVEKLR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTLD_VIBC3
Sequence: MKKNAVHFGAGNIGRGFIGKLLADADIAVTFADVNEPLVDQLSHQQEYKVKVVGSECKMETVSHVTAVNSASEALIERIIKTDLVTTAVGPTVLDIIAKTIAKGLSARFAAGNTQPLNIIACENMVRGTTHLKQQVYQFLTTEEQQQADALVGFVDSAVDRIVPPLQAANDDPLEVTVESFSEWIVDEQQFKGEIPQIEGMEKTDNLMAFVERKLFTLNTGHCVTAYLGCLKGHRTIREAIEDPCIHAQVKQAMQESGEVLIRRYGFDRALHSAYIEKILSRFANPYLVDEVDRVGRQPLRKLSANDRLIKPLLGTIEYGLPNGMLLKGIAAALKYRNSSDPQAVELQQSIEKEGVRSTLARYTGLAAESVEAQQIEALYQQMD
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: AMPA_HELPS
Sequence: MLKIKLEKTTFENAKAECGLVFIINKDFDHAWVKNKKLLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCDTHSKDNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPCEKTCANSLEKSAKEALKYAEIMTESLNIVRDLVNTPPMIATPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLSPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGAGVRACTAFVEEFLKKA
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOAH_SALPA
Sequence: MFAGLPSLSHEQQQKAVERIQELMSQGMSSGEAIAQVAGELRANHTGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: IOVO_NEOJU
Sequence: VATVDCSGYPKPACTMEYMPLCGSDNKTYGNKCNFCNAVVDSNGTLTLSHFGEC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: CIDA_STAAE
Sequence: MHKVQLIIKLLLQLGIIIVITYIGTEIQKIFHLPLAGSIVGLFLFYLLLQFKIVPLTWVEDGANFLLKTMVFFFIPSVVGIMDVASEITLNYILFFAVIIIGTCIVALSSGYIAEKMSVKHKHRKGVDAYE
What is the function of this protein?
Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation.  Inhibited by the antiholin-like proteins LrgAB.  In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins.  When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability.  These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential.
What are the official names of this protein?
Holin-like protein CidA.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. CidA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TM267_MOUSE
Sequence: MASKVEKTHALPPCCSTESLISSIGLGIFCLVADRLLRFPIIQHNDWLRAISDNIVHGVIGMWSWAVVTGIRKKSDFGEVLLAGFLASVIDVDHFFQARSLSLQAALTLPRRPFLHCSTVIPIAVLSVKLAVHLFKLRDSWRFLPWMILVSWTSHHIRDGIRHGLWICPFGKTPPLPSSFYVISTLSLPHLCSFLMYLTGTRQTVSSKYGMRIDV
What are the official names of this protein?
Transmembrane protein 267.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HIS8_FRAP2
Sequence: MQKIVQNQTTESLIRKDLQKFSAYSSARSLKVDGDIWLNANESPYNDEYLYNRYPEPQPRKLVEKLAKIYDVDASNILVTRGSDEGIDLLFRLYCEYQKDSAFAVEPTFGMYKIAAQLQGVDYKTLKLKEENNFEINITELLANIPDNCKLLFLCTPNNPTGKSIPLADIEQILSELAGNCVVVVDEAYIEFSNEKSVSSIINKYENLVVLRTLSKSFGMAGLRLGVVITNSDRIVWLRKILAPYPIPKTTESTILAMLDDENLANIASQIIEIKEQREHLYQALSQMKIVDKLWSSDANFILVRFRESIFNKLIDNKIVVRSMAHFFNDEKVLRISIGTVSENKRLIEVLQKLSSEYETK
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: PPI1_BRUSU
Sequence: MSFIRSALAAAAFVALSIGAVQTASAADPENTVILKLKDGDVALELRPDLAPKHVAQIKKLVREGAYNGVAFHRVIPGFMAQTGDVKFGNMDKGFDAARVGTGGSNYPDLPAEFSKEPFVRGTVGMARSQNPNSANSQFFIMFDDGPFLNGQYTVVGKVVSGMDAVDKIKKGSEAENGAVKNPDKIIKATIEADTK
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Probable peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DGTL1_CORGB
Sequence: MYPYSDADAFRRHPERAKSSQLRTSAVDTRSAFARDRARVLHSAALRRLADKTQVVGPNDGDTPRTRLTHSLEVAQIARGIGAGLDLDPDLCDLAGLCHDIGHPPYGHNGENALNEVAAACGGFEGNAQTLRILTRLEPKIVSDEGASFGLNLSRAALDAACKYPWAKTNADGSVNKKYSAYDEDAEILDWIRQGHEDLRPPIEAQVMDFSDDIAYSVHDVEDGIVSGRIDLKVLWDLVELAALADKGAAAFGGSPAELIEGAASLRELPVVAAAADFDFSLRSYAALKAMTSELVGRYVGSTIESTKKTHAGIDVGRMYGDLIIPETAASEVKLLKTLAVLYVMDDPGHLARQNRQRDRIFRVFDYLVLGAPGSLDPMYRQWFIEANSESEQIRVIVDQIASMTESRLERLARNAADISGFLG
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: GRCA_MANSM
Sequence: MIKGIQITKAANDNLLNSFWLLDSDKGEARCLAAKAEFAEDQIVAINELGQIEYRELAVDVAPTIKVEGGQHLNVNVLRRETLEDAVNNPDKYPQLTIRVSGYAVRFNSLTPEQQRDVITRTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: RLMN_MYCBP
Sequence: MVPELMFDEPRPGRPPRHLADLDAAGRASAVAELGLPAFRAKQLAHQYYGRLIADPRQMTDLPAAVRDRIAGAMFPNLLTASADITCDAGQTRKTLWRAVDGTMFESVLMRYPRRNTVCISSQAGCGMACPFCATGQGGLTRNLSTAEILEQVRAGAAALRDDFGDRLSNVVFMGMGEPLANYARVLAAVQRITARPPSGFGISARAVTVSTVGLAPAIRNLADARLGVTLALSLHAPDDGLRDTLVPVNNRWRISEALDAARYYANVTGRRVSIEYALIRDVNDQPWRADLLGKRLHRVLGPLAHVNLIPLNPTPGSDWDASPKPVEREFVKRVRAKGVSCTVRDTRGREISAACGQLAAVGG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT1_PLAFX
Sequence: MGEEDVQALVVDNGSGNVKAGVAGDDAPRSVFPSIVGRPKNPGIMVGMEEKDAFVGDEAQTKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRAAPEEHPVLLTEAPLNPKGNRERMTQIMFESFNVPAMYVAIQAVLSLYSSGRTTGIVLDSGDGVSHTVPIYEGYALPHAIMRLDLAGRDLTEYLMKILHERGYGFSTSAEKEIVRDIKEKLCYIALNFDEEMKTSEQSSDIEKSYELPDGNIITVGNERFRCPEALFQPSFLGKEAAGIHTTTFNSIKKCDVDIRKDLYGNIVLSGGTTMYEGIGERLTRDITTLAPSTMKIKVVAPPERKYSVWIGGSILSSLSTFQQMWITKEEYDESGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm (PubMed:15670824).  Polymerizes into shorter and less stable actin filaments compared to ACT2/actin-2; this is thought to facilitate gliding motility and host cell invasion (PubMed:15670824).  Has ATPase activity (By similarity).  ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi (By similarity).  ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin (By similarity).  Plays an essential role during the asexual blood stage (By similarity).  At the segmented schizont stage, required for apicoplast migration and segregation into individual daughter merozoites (By similarity).  Also, required for the separation of daughter merozoites in the final stages of cytokinesis (By similarity).  Essential for merozoite invasion of, but not adhesion to or reorientation towards, host erythrocytes (By similarity).
What are the official names of this protein?
Actin-1, PfACT1, Actin I.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MRAY_ECO24
Sequence: MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDK_SHEHH
Sequence: MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIIASKMVHLSQEQAEGFYAEHSERPFFGALVAFMTSGPIMVQTLEGENAVLAHREILGATNPAEAAEGTIRADFAESIDENAAHGSDSVASAEREIAYFFSTEELCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATA_HELPJ
Sequence: MGGFTSIWHWVIVLLVIVLLFGAKKIPELAKGLGSGIKNFKKAVKDDEEEAKNELKTLDAQATQTKVHETSEIKSKQES
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ARGJ_CANAW
Sequence: MHKVTKFAIRHLSDKASRFVPKAGVYPKGYAVGGIHCGVKKDGKSLDLAILQNTFGKNASAAGVFTVNKFKAAPVQVSKKILKEKSGSGINSFVINSGNANAVTGAQGMKDAEDMVLVTDSVLENPTNSSLVMSTGVIGNNLPIDKILGGIPKLASQHLGNTHQHWIDCATAICTTDTFPKLVTKRFSIGDDTYTLAGLCKGAGMICPNMATLLGFFVTDAPVTPSALQQILKYAVDRSFNSITVDGDMSTNDTIVAMANGAAGGEVIDNTSSCAERYSRLQAEIVDFAQQLAQLVVRDGEGATKFITIRVKDALSYKDAKSIASSIANSSLFKTAMYGKDANWGRILCAIGYADVTSANSVIPEKTSVKFVPVDGSEHLNLLVNGEPEQVDEERASEILQNEDLIVEINLGTNGGQSADFWTCDLSHEYVTINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: KAT_DICDI
Sequence: MLRNTVKRLMTYTFKPSKQTSSFGPSVWLEFSPLAIKYNAVNLGQGFPNFEPPKFVKDAMIKTIEVGGFNQYTRSPGHIRLVKALSSVYSPYFGRELNAMTEIMVGVGASESLFAAISSIVNEGDEVILIEPFFDIYIGPILMAGGIPKFVTLKEEESSQAGSSDKKRSSKHWKINKEELAAAFTDKTKLIILNNPHNPVGKVYSKEELQEIADVVAKHGPNTTVISDEVYEWMTFDGEEHHRFATLPGMWERTITIGSAGKTFSITGWKVGWCIGPSNIIGAIANTHQYVPFSVPTPTQEAVAIALEQPNIKDYFKELATMYQNKRDTLLNSLTQAGLDPVIPQGTYFIMGDTSSIHLQGDQGKDTSITGMGLHLRDWNIARYLTTEYGVTTIPPSAFYCDDHQKIPENFVRFTFCKDDLTLQKAHDNLLKLKK
What is the function of this protein?
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA).  Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites.  Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity).
What are the official names of this protein?
Kynurenine--oxoglutarate transaminase, Glutamine transaminase K, Glutamine--phenylpyruvate transaminase, Kynurenine aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.