PharMolix/UniProtQA huggingface dataset:
Protein: KAD_SHEDO
Sequence: MRIILLGAPGAGKGTQAQFIMQQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERIAQDDCVKGFLLDGFPRTIPQADAMAANGIEIDHVIEIDVPDEEIVKRMSGRRVHSGSGRVYHVVFNPPKVEGKDDVTGEDLSIRPDDEESTVRKRLDIYHEQTKPLVEYYGNVAAQGKTQYNKFDGTQSVAAVSEQLAKVIG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_HISS2
Sequence: MQKFHVYGQSRLNGEVNISGAKNAALPILFAAILAEEPVKLTNVPELKDIDTTLKILQQLGVVTYRDEQGAVHLDASNINHFVAPYELVKTMRASIWALAPLVSRFKQGQVSLPGGCSIGARPVDLHISGLERLGAKIVLEDGYVKAFVDGQLIGKRIVIEKVSVGATLSIMIAATLAKGITVIENAAREPEITDTAVFLNKMGAKISGAGSDIITIEGVERLGGCEHSIVPDRIETGTFLVAAAISGGRIICKNTKASTLDAVIDKLRDAGAKIEVTENTITLDMQGNRPKAVNIRTEPYPGFPTDMQAQFTLLNMVAEGSSKITETIFENRFMHIPELIRMGGKAEIEGNTAFCHGVEYLSGAEVMATDLRASISLVLAGCIATGETIVDRIYHIDRGYEHIEKKLRGLGAKIERFTEKIVD
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYF_NOSP7
Sequence: MRNVFRTARLTRSARAIVKTLLIAIATVTFYFTSDLALPQSAAAYPFWAQQTYPETPREPTGRIVCANCHLAAKVTEVEVPQSVLPDTVFKAIVKIPYDLSAQQVGADGSKVGLNVGAVLMLPEGFKIAPEDRISEELKEEIGDTAFQPYSEDKENVVIVGPLPGEQYQEIIFPVLSPNPATDKNIHFGKYSVHVGGNRGRGQVYPTGEKSNNSVYNASATGTITKIAKEEDADGNVKYLVNIQPESGDVVVDTVPLGPDLIVSEGQAVKTGDALTNNPNVGGFGQIDAEIVLQDSSRVKWMIAFVALVMLAQVMLVLKKKQVEKVQAAEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: ACCD_PROMP
Sequence: MSLIDWFAARRKDQFVGKVSQDPEESDGLWVKCSECGQVAYRKDLISNFNVCSNCGHHNRINSDERINIIADKDSFKEFDESLSPTDPLKFKDRRSYSERIKESQQGTGLKDGVITGLCSVNSMPLALAVMDFRFMGGSMGSVVGEKITRIVETATIKNYPILIVCASGGARMQEGMLSLMQMAKISGALKKHRAKNLLYMPLLTHPTTGGVTASFAMLGDLILAEPKALIGFAGRRVIEQTLREKLPDNFQTAEYLLEHGFVDVIVNRKELKSTLTKLLKIHGVKELVQTN
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_RICPU
Sequence: MNIHEYQAKEILRKYGVPTSTGLVVTQTEKINETIDKLNTEVYVVKAQIHAGGRGKAGGVKVVKSKEEAKKVAHDMFGINLVTHQTGPQGQKVNRLYIESGCDILKEYYFSIVFDRSASCITFIASTEGGVDIEEVAEKTPEKIIKFSVDPATGLQDFHMRGIAYELGFKDNQAKQMKEIVKSVYNAFIETDAAQIEINPLIVNSDGHLLALDAKITFDDNGLLRHPNITAMRDHDEEDPLETRAANAGLSYVKMDGNIGCMVNGAGLAMATMDIIKLYGASPANFLDVGGGADRERVKEALKIILSDKEVQGILVNIFGGIMRCDIIAEGIIAAAKDIGIKVPLVVRLAGTNVEKGEEILSNSGLEIIPAHDLADAANKIVEAIR
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: GLMS_BRUSU
Sequence: MCGIIGIIGNDEVAPRLVDALKRLEYRGYDSAGIATLQNGRLDRRRAEGKLVNLEKRLAGEPLPGVIGIGHTRWATHGRPVERNAHPHITTRLAVVHNGIIENFAELRAMLEAEGRKFETETDTEAVAHLVTRELEKGKSPVEAVRDCLPHLKGAFALAFLFEGDEELLIGARQGPPLAVGYGEGEMFLGSDAIALAPFTDTISYLEDGDWAVLTRNGVSIYDENNKPVERPVQKSQNTNMLVSKGNHRHFMQKEMFEQPEVISHTLANYLDFTTGKVRKEAIGIDFSKVDRLTITACGTAYYAATVAKYWFEQIARLPVDSDIASEFRYREMPLSKDSLAMFVSQSGETADTLASLRYCKAQGLKIASVVNVTGSTIARESDAVFPTLAGPEIGVASTKAFTCQLSAMASLAIAAARARGAIDEVREQELVHQLSEAPRFINQVLKLEDQIAAVCHDLSKVNHVLYLGRGTSFPLAMEGALKLKEISYIHAEGYAAGELKHGPIALIDETMPVIVIAPSDRLYEKTVSNMQEVAARGGRIILITDKKGAESASIDTMATIVLPEVPEFISPLVYALPIQMLAYHTAVLMGTDVDQPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_PROMM
Sequence: MLKLLLGDPNARKLKRYQPIVTDINILEEDIALLSDDQLRSKTADFRQQFENVVSFAKQRALLDELLPEAFAVVREAAKRVLGMRHFDVQLIGGMVLHEGQIGEMKTGEGKTLVATLPSYLNALTGRGVHVVTVNDYLARRDAEWMGQVHRFLGLSVGLIQQDMSPAERRRNYACDITYATNSELGFDYLRDNMATDLSEVVQREFQYCVIDEVDSILIDEARTPLIISGQVERPQEKYQQAADVAAALERAAEQGKDGIDPEGDYEVDEKQRSCTLTDEGFAKAEQNLRVRDLFDPADPWAHYITNALKAKELFVRDVNYIVRDGEAVIVDEFTGRVMPGRRWSDGQHQAIEAKEQLAIQPETQTLASITYQNFFLLYPRLAGMTGTAKTEEVEFEKTYKLETSVIPTNQPRARADWVDQVYKTESAKWRAVANETAEIHKQGRPVLVGTTSVEKSELLSSLLSEQEIPHNLLNAKPENVEREAEIVAQAGRAGAVTIATNMAGRGTDIILGGNSDYMARLKLREVLLPRLVRPEEGHRPPVPLQRAAETGGGFAAKAAASNGSHGHVLSEARAIGSLYPCSLTDDTDQFLAELARELVKVWGDRALSVIELEDRISTAAEKAPTDDAQIAALRESIARVKTEYDVVVTQEEVRVREAGGLHVIGTERHESRRVDNQLRGRAGRQGDLGSTRFFLSLEDNLLRIFGGERVASLMNAFRVEEDMPIESGMLTRSLEGAQKKVETYYYDIRKQVFEYDEVMNNQRRAVYAERRRVLEGRGLKKQVIGYGERTMDDIVEAYVNPDLPPEEWDLGQLVSKVQQFVYLLEDLKPEQLQGLSMEELKSFLQEQLRNAYDIKEGQIEQQRPGLMREAERFFILQQIDTLWREHLQAMDALRESVGLRGYGQKDPLIEYKNEGYDMFLEMMANMRRNVIYSMFMFQPAASGQEQA
What is the function of this protein?
Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: WAP3_PHIOL
Sequence: MKPWILLLLAGLLILSTQLTTAKTTKQLRLPKVKPGECPKVKIPPDYPCNQYCVWDFDCEGNKKCCPVGCAKECFPPGPL
What is the function of this protein?
Damages membranes of susceptible bacteria.  Has no hemolytic activity.  Not toxic to mice.  Does not inhibit the proteinases elastase and cathepsin G.
What are the official names of this protein?
Waprin-Phi3.
What is the protein family that this protein belongs to?
Belongs to the snake waprin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GMHA_ACTP7
Sequence: MYLAQIKAELQEAADVLDKFMSDEKNIQLIQDAALLISNSFKQGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHLSCVSNDFGYEYVFSRYLEAVGQKGDVLFGLSTSGNSKNVLNAIKVAKEKGMKVIAMTGKDGGQMAGLADVEIRVPHFRYADRTQEIHIKVIHILMMLIEFEMAKQA
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAFD_SHIDS
Sequence: MRKNTYAMRYVAGQPAERILPPGSFASIGQALPPGEPLSTEERIRILVWNIYKQQRAEWLSVLKNYGKDAHLVLLQEAQTTPELVQFATANYLAADQVPAFVLPQHPSGVMTLSAAHPVYCCPLREREPILRLAKSALVTVYPLPDTRLLMVINIHAVNFSLGVDVYSKQLLPIGDQIAHHSGPVIMAGDFNAWSRRRMNALYRFAREMSLRQVRFTDDQRRRAFGRPLDFVFYRGLNVSEASVLVTRASDHNPLLVEFSPGKPDK
What are the official names of this protein?
UPF0294 protein YafD.
What is the protein family that this protein belongs to?
Belongs to the UPF0294 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_SHEB5
Sequence: MNPIVKSFEYGQHTVTLETGVIARQADAAVLASMGDTTVLVTVVGKKEADAGRDFFPLTVNYQEKTYAAGKIPGGFFKREGRPSEDETLIARLIDRPIRPLFPNGFKNEVQVIITVVSVDPQIEPDIISMIGTSAALAISGIPFSGPLGAARVGYIDGEYVLNPSVAQLATSQLNLVVAGTAGAVLMVESEAQALPEEVMLGSVVYGHDQQQVVIKAIAEFKAEAGKPTWDWTAPTQDADLVAQIKELAEAGLGDAYKIQVKQDRYAQVSVVKAATKEALLASNPSIDLREVDNLLGSLEKKVVRGRIIRGEPRIDGREPDMIRALSVLAGVLPRTHGSALFTRGETQALVTCTLGTERDAQKIDSIMGERTNRFMLHYNFPPYSVGETGMVGSPKRREIGHGKLAWRGINAVMPSAAEFPYSVRVVSEITESNGSSSMASVCGTSLALMDAGVPIKTSVAGIAMGLVKEGDDFVVLSDILGDEDHLGDMDFKVAGTRDGITALQMDIKIEGITKEIMDIALQQAYGARVHILNVMDQAIGSHRDDISDHAPRITVIKINPEKIRDVIGKGGAVIRALTEETGTTIELEDDGTVKIASSNGEATKEAIRRIEEITSEVEVGRIYNGKVIRIVDFGAFVNILPGKDGLVHISQISDERVANVSDHLELNQEVAVKVMEVDRQGRVRLSIKEAQTKETAAAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y930_MYCBO
Sequence: MVRRALRLAAGTASLAAGTWLLRALHGTPAALGADAASIRAVSEQSPNYRDGAFVNLDPASMFTLDREELRLIVWELVARHSASRPAAPIPLASPNIYRGDASRLAVSWFGHSTALLEIDGYRVLTDPVWSDRCSPSDVVGPQRLHPPPVQLAALPAVDAVVISHDHYDHLDIDTVVALVGMQRAPFLVPLGVGAHLRSWGVPQDRIVELDWNQSAQVDELTVVCVPARHFSGRFLSRNTTLWASWAFVGPNHRAYFGGDTGYTKSFTQIGADHGPFDLTLLPIGAYNTAWPDIHMNPEEAVRAHLDVTDSGSGMLVPVHWGTFRLAPHPWGEPVERLLAAAEPEHVTVAVPLPGQRVDPTGPMRLHPWWRL
What are the official names of this protein?
Uncharacterized protein Mb0930.
What is the protein family that this protein belongs to?
To K.pneumoniae RomA.
Protein: PSBF_CANWI
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: FABH_MYCBO
Sequence: MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPL4_ASPNC
Sequence: MASRPIVLRFESRNGQFRLTVNPQDLFPSLQPQILERLPPNVDPSSITLSNRPIGTGGEERLLNSLDGVGFDKVGLKHGDKLFIGYQENQGQQNGTANGHITPSAGDASRRLNGAPVPQSETATIKNPWDVVQQSPLDDMLDKKDGKIKRGLDTKFCRHGPKGMCDYCMPLEPYDPKYLAEKKIKHLSFHSYLRKINASTNKAELNSSFMPPLSEPYYRVRRDCPSGHPQWPEGICTKCQPSAISLQPQEFRMVDHVEFSSPDLINSLLDFWRKSGAQRLGFLYGTYEEYKEVPLGVKAVVQAIYEPPQVDEVDGVTLHEWPNEKEVDEVAHLCGLERIGVIFTDLLDAGRGDGSVICKRHIDSYYLSSLEIAFAARMQAQHPKATKWSRTGRFGSNFVTCVLSGDEEGAISVSAYQASVAAVEMVRADIVEPSAEPSVMLVQSEDDDTENKSRYIPEVFYRKINEYGVSAQQNAKPSFPVEYLLVTLTHGFPTDASPLFTDSSFPIENREVIGESQELVHVAKKLVTHGDPDKAIQAVSDFHMLCFLHSLSTFNKDEEALLCRVATQRAPADGLQLINTPGWATLVTILQESGERPPKRPWLPTPEPYPPRSVPYNPGKRSLPSSSSSSHLRPESPKSESERLAKRFKGASLE
What is the function of this protein?
Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus.  Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).
What are the official names of this protein?
Nuclear protein localization protein 4.
What is the protein family that this protein belongs to?
Belongs to the NPL4 family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes mainly at the nuclear periphery and the endoplasmic reticulum membrane.
Protein: 4HYPE_BRUAB
Sequence: MARHSFFCVDGHTCGNPVRLVAGGGPNLNGSTMMEKRAHFLAEYDWIRTGLMFEPRGHDMMSGSILYPPTRPDCDVAVLFIETSGCLPMCGHGTIGTVTMAIEQGLVTPKTPGKLNLDTPAGLVAIEYEQDGQYVERVRLTNVPAFLYAEGLEVECPDLGPIKVDVAYGGNFYAIVEPQENYTDMDDYSALQLIAWSPVLRQRLNEKYKFQHPELPDINRLSHILWTGKPKHPQAHARNAVFYGDKAIDRSPCGTGTSARMAQLAAKGKLKPCDEFIHESIIGSLFHGRVERAAEVAGRPAIVPSIAGWARMTGYNTIFIDDRDPFAHGFSMA
What is the function of this protein?
Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4-hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases.  Strong B-cell mitogen.  Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways.
What are the official names of this protein?
4-hydroxyproline epimerase, Hydroxyproline-2-epimerase, BaHyPRE.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: PUR5_BORPA
Sequence: MTNQHSAPLTYRDAGVDIDAGDALVDRIKPLAARTMRPGVLVGIGGFGALFEVPKKFREPVLVSGTDGVGTKLRLAFDWNRHDTVGIDLVAMSVNDILVQGAEPLYFLDYFACGKLSVDTAAAVVGGIARGCELAGCALIGGETAEMPGMYPDGEYDLAGFAVGAVDKSAIIDGKSIQPGDVVLGLASSGAHSNGYSLVRKILERAGARPDQDFHGQPLVDVVMAPTRIYVKQVLAALDRHGPAIKGLAHITGGGLLDNVPRILQPGMAAQLQRDGWEMPKLFQWLQQQGSVADAEMHRVFNCGIGMVLVVAADQADAVAATLREQGEIVNRIGEIVPQQDGMAQTVVV
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S22A2_PIG
Sequence: MLTVDDILEHTGEFNFFQKQTFFLLALLSAAFTPIYVGIVFLGFIPDHRCRSPGVAELSQRCGWSLAEELNYTVPGPGPAGQAFPRQCRRYEVDWNQSTLGCVDPLAGLAANSSHLPLGPCRYGWVYDTPGSSIVTEFDLVCANSWLLDLFQSAVNVGFFIGSVGIGYIADRFGRKLCLLLTILINAVSGVLMAISPTYTWMLVFRLIQGLVSKAGWMIGYILITEFVGLSYRRTVGIFYQVAFTFGLLVLAGVAYALPHWRWLQFTVTLPNFCFLFYYWCVPESPRWLISQNKNAKAMSIIKHIAKKNGKSLPASLQSLRPDEEVGEKLKPSFLDLVRTPQIRKHTLILMYNWFTSAVLYQGLVMHMGLAGSNLYLDFFYSALVEFPAALLILLTIDRLGRRHPWAASNVVAGAACLASVFIPEDPHWLRITVLCLGRMGITMAYEMVCLVNAELYPTFIRNLGVLVCSSMCDIGGIITPFLVYRLTDIWHELPLVVFAVVGLIAGGLVLLLPETKGKTLPETIEEAETMRRPRKNKEKIIYLQVKKLDIPPN
What is the function of this protein?
Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics.  Functions as a Na(+)-independent, bidirectional uniporter.  Cation cellular uptake or release is driven by the electrochemical potential, i. e.  membrane potential and concentration gradient (By similarity).  However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (By similarity).  Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow.  Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters.  Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system.  Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium.  Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN).  Mediates the uptake and efflux of quaternary ammonium compound choline.  Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamines putrescine and spermidine.  Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha).  Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP).  May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity).
What are the official names of this protein?
Solute carrier family 22 member 2, Apical organic cation transporter, Organic cation transporter 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ERPA_PSET1
Sequence: MSEELPIKFTDAAADRVKQLIDEEENPELKLRVYVTGGGCSGFQYGFTFDEKANPGDLEIVKNGVMLVVDPMSLQYLVDGEVDYTEGLEGARFFVTNPHATTTCGCGSSFTI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: ENO_CAMJJ
Sequence: MLVIEDVRAYEVLDSRGNPTVKAEVTLSDGSVGAAIVPSGASTGSKEALELRDNDERFGGKGVLKAVANVNETIADEILGLDAFNQTQLDDTLRELDGTNNYSNLGANATLGVSMATARAAAAALGMPLYRYLGGANASILPVPMCNIINGGAHANNNVDFQEFMIMPFGFTSFKEALRSVCEIYAILKKELANSGHSTALGDEGGFAPNLANNTEPIDLLMTCIKKAGYENRVKIALDVASTEFFKDGKYHMEGKAFSSEDLIERYVELCAKYPICSIEDGLAENDFEGWIKLTEKLGNKIQLVGDDLFVTNEDILREGIIKKMANAVLIKPNQIGTITQTMRTVRLAQRNNYKCVMSHRSGESEDAFIADFAVALNTGQIKTGALARGERTAKYNRLLEIELESDEYLGEKL
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: HEM3_PYRAR
Sequence: MRLVVATRGSKLSMLQTEELLAQIKAVEPSIEFEIKIVKTTGDEVQDKPLYQIGVKGIFEKEVNLAVLRGEADVAVHSLKDLPSELSPGLVLAGFSKRAPPFDAVVSTAGYVLETLPRGALVGTSSVRRAEFVKAIRPDVRVEPLRGNVDTRINKILQGKYDAAIMAVAGIYRLYGASPPIKLAVLRPEVLPPPPGQGIVAAVVREADSWLIDLLKKASDPKASLEAIAEREFLKAVGAGCHVAIGGVAFARNDTVEFIAGYASGGRKYIVRVVGDDPVEVGRRAAEEIRKFKDGDV
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Probable porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: GATA_LACGA
Sequence: MNYLNENIDSLNKKLQDGEITAEDLAKETVKNIKETDKKINAWITVDDDAKPAENLDFAKNKLAGIPIAIKDNIITNGMKTTAASHILCNYMPVYDATVISKLKKAQATFVGKTNMDEFAMGSSTEHSYYGATRNPWDLEKVPGGSSGGSAAAVASGEVVAALGSDTGGSIRQPAAFNGIFGIKPTYGRVSRWGLIAFGSSLDQIGVMSKRVKDSAEVLNVIAGPDEHDATVSEKEVPDFTSFLGQDVKGLRVAVPKEYMDAVDGEMRDAIQKQIDVLKDAGAVINEVSLPHTKYVVPTYYIVASSEASSNLQRYDGIRYGYRAKDTKNLLDVYVKSRSEGFGDEVKRRIMLGSFALSAGAYDEFFKKAAQVRTLICRDFEKIFEENDVIVGPTTTEPAFGIGEEISDPIKMYNNDILTISANLAGIPAASVPAGLVDGMPAGLQIMAKRFDEGTVFKVADFIERNNKFYEKTPTGMED
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.