PharMolix/UniProtQA huggingface dataset:
Protein: SBT3E_ARATH
Sequence: MENCLSTLVFLLSIALVLFPKTGVSFLAAEGASDSDSKVYIVYLGEREHDDPELFTASHHQMLESLLQSKDDAHNSLIYSYQYGFSGFAALLTSSQAKKISEHPEVIHVIPNRILKLKTTRTWDHLGLSPNPTSFSSSSSAKGLLHETNMGSEAIIGVVDTGIWPESKVFNDHGLGPIPQRWRGKCESGEQFNAKIHCNNKLIGAKYYLSGLLAETGGKFNRTIIQDFKSNRDAIGHGTHTATIAGGSFVPNVSFYGLARGTVRGGAPRARIASYKVCWNVVGYDGICTVADMWKAFDDAIHDQVDVLSVSIGAGIPENSEVDSVDFIAAFHAVAKGITVVAAGGNDGPGAQNITNAAPWLLTVAATTLDRSFPTKITLGNNQTLFAESLFTGPEISTSLAFLDSDHNVDVKGKTILEFDSTHPSSIAGRGVVAVILAKKPDDLLARYNSIPYIFTDYEIGTHILQYIRTTRSPTVRISAATTLNGQPAMTKVAEFSSRGPNSVSPAILKPDIAAPGVSILAAVSPLDPDAFNGFGLYSGTSMSTPVVSGIIALLKSLHPNWSPAAMRSALVTTAWRTSPSGEPIFAQGSNKKLADPFDYGGGLVNPDKAAQPGLVYDMGIKDYINYMCSAGYIDSSISRVLGKKTKCTIPKPSILDINLPSITIPNLEKEVTLTRTVTNVGPIKSVYKAVIESPLGITLTVNPTTLVFNSAAKRVLTFSVKAKTSHKVNSGYFFGSLTWTDGVHDVIIPVSVKTTISM
What are the official names of this protein?
Subtilisin-like protease SBT3.14, Subtilase subfamily 3 member 14, AtSBT3.14.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HBG1_PANPA
Sequence: MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFRLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVASALSSRYH
What is the function of this protein?
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
What are the official names of this protein?
Hemoglobin subunit gamma-1, Gamma-1-globin, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: FOLD_COXB2
Sequence: MIARILDGRTCAEKVKARVKENIRLLQEKGLPSPGLAVILVGNDPASATYVAHKERACQAVGIRSTVYRMPNTITESELASKIDECNRDSNTHGILLQLPLPAHIDSANLLERIRPDKDVDGFHPYNLGRLVQRRPALRPCTPYGVMTLLTETHENLEGKHAVIVGASNIVGRPMALELLLAKCTVTVCHRFTRDLAEHVKSAELLIVAIGKPGIIQSEWIKPGAIVIDVGFSRLSPNKIAGDIDFETAKERASWITPVPGGVGPMTVATLLENTLQAAQTFL
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: MNMC_YERPE
Sequence: MNQRPIQTATLSWNEQGTPVSEQFGDIYFSNEDGLEETHHVFLKGNGFPARFASHPQQSCIFAETGFGTGLNFLTLWRDFALFRQQSPNATLRRLHYISFEKYPLHVADLASAHARWPELASFAEQLRAQWPLPLAGCHRILLADGAITLDLWFGDVNTLLPTLDDSLNNQVDAWFLDGFAPAKNPDMWNEQLFNAMARMTRPGGTFSTFTAAGFVRRGLQQAGFNVTKVKGFGQKREMLTGTLPQQIHAPTAPWYHRPAATRCDDIAIIGGGIVSALTALALQRRGAVVTLYCADAQPAQGASGNRQGALYPLLNGKNDALETFFTSAFTFARRQYDQLLEQGIAFDHQWCGVSQLAFDDKSRGKIEKMLHTQWPVEFAEAMSREQLSELAGLDCAHDGIHYPAGGWLCPSDLTHALMMLAQQNGMTCHYQHELQRLKRIDSQWQLTFGQSQAAKHHATVILATGHRLPEWEQTHHLPLSAVRGQVSHIPTTPVLSQLQQVLCYDGYLTPVNPANQHHCIGASYQRGDIATDFRLTEQQENRERLLRCLPQVSWPQQVDVSDNQARCGVRCAIRDHLPMVGAVPDYAATLAQYQDLSRRIQHGGESEVNDIAVAPVWPELFMVGGLGSRGLCSAPLVAEILAAQMFGEPLPLDAKTLAALNPNRFWIRKLLKGRPVQTRSPATQESSR
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_STAAM
Sequence: MNTLNLDIVTPNGSVYNRDNVELVVMQTTAGEIGVMSGHIPTVAALKTGFVKVKFHDGTEYIAVSDGFVEVRKDKVSIIVQTAETAREIDVERAKLAKARAESHLENDDDNTDIHRAERALERANNRLRVAELK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS17_ECOL6
Sequence: MTDKIRTLQGRVVSDKMEKSIVVAIERFVKHPIYGKFIKRTTKLHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAVL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: LRC14_XENLA
Sequence: MESLVSVCAQKLVCDHSSLRRALDLMPKELYPALFKAAFLGKKTLVLQDLVQTWPFAVLSFHKLLNSNRHCDPQLATEKPSKLCVQTVILGVITYLSDALTKGPEGPQAGRQRLRLLDMTGMQEEGLEQNPDTMSLWSRTVTLAKACIDVSKRHSEEVMQVSKRRRSCHINALPASSPLYIEVRVDLFVNSTSYGVLREALLVSSHSPLRLQCRDFRAEELSLRSTAGLLELLNPGSVRQIDLRFNNLGLSGLNVLLPHMAKFSHLQSLKLPYSNVDVRRLSPVMEEGLQSFASQLGQLGALKELNLGSSRLSGRLRQLLGGLQRPLESLELAFCSLLPMDLSYLSQSSHMSSLRKLDLSGNNLSEFLLTPFLHLLAEISGHLLYLDVMECKLADAHLSALMPILCRCSWLRYLGLFCNPISSDGLRMVLQNLVRLPELHLVVYPFPVDCYSDPTHFSSTAASLDSSFDHEKLTRVGEELQQMLVRAQRMDMVWTTDMYVQRTLDSLSL
What are the official names of this protein?
Leucine-rich repeat-containing protein 14.
What is the protein family that this protein belongs to?
Belongs to the PRAME family. LRRC14 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR11_CICAR
Sequence: MAKSISKIGSRKNARIGSRKQTRKIPKGVIYVQASFNNTIVTVTDVRGRVISWSSAGSCGFKGTRRGTPFAAQTAAANAIRTVVDQGMQRAEVIIKGPGLGRDAALRAIRRSGILLRFIRDVTPMPHNGCRAPKKRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSAD_NICSY
Sequence: MAMATQASLFTPALSAPKSSAPWKQSLASFSPKQLKSTVSAPRPIRAMAEEAATKEAEAPVGFTPPQLDPNTPSPIFGGSTGGLLRKAQVEEFYVITWESPKEQIFEMPTGGAAIMREGANLLKLARKEQCLALGTRLRSKYKINYRFYRVFPNGEVQYLHPKDGVYPEKVNAGRQGVGQNFRSIGKNKSPIEVKFTGKQVYDL
What is the function of this protein?
PsaD can form complexes with ferredoxin and ferredoxin-oxidoreductase in photosystem I (PS I) reaction center.  PSAD may encode the ferredoxin-docking protein.
What are the official names of this protein?
Photosystem I reaction center subunit II, chloroplastic, Photosystem I 20 kDa subunit, PSI-D.
What is the protein family that this protein belongs to?
Belongs to the PsaD family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: O2T34_HUMAN
Sequence: MCSGNQTSQNQTASTDFTLTGLFAESKHAALLYTVTFLLFLMALTGNALLILLIHSEPRLHTPMYFFISQLALMDLMYLCVTVPKMLVGQVTGDDTISPSGCGIQMFFHLTLAGAEVFLLAAMAYDRYAAVCRPLHYPLLMNQRVCQLLVSACWVLGMVDGLLLTPITMSFPFCQSRKILSFFCETPALLKLSCSDVSLYKMLTYLCCILMLLTPIMVISSSYTLILHLIHRMNSAAGRRKALATCSSHMIIVLLLFGASFYTYMLRSSYHTAEQDMMVSAFYTIFTPVLNPLIYSLRNKDVTRALRSMMQSRMNQEK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2T34, Olfactory receptor OR1-63.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CPFC_STRCO
Sequence: MPDVLDASPYDALLLLSFGGPEGPDDVVPFLENVTRGRGIPKERLKEVGQHYFLFGGVSPINDQNRALLDALRKDFAEHGLDLPVYWGNRNWAPYLTDTLREMVGDGRRRILVLATSAYASYSGCRQYRENLADALAALESEGLELPKIDKLRHYFNHPGFVEPMVDGVVRSLAELPAEVRDGAHIAFCTHSIPTSAADGSGPVEEHGDGGAYVRQHLDVARLIADAVRERTGVDHPWQLVYQSRSGAPHIPWLEPDICDHLEERQAAGVPAVVMAPIGFVSDHMEVLYDLDTEATAKAEELGLPVRRSATVGADPRFAAAVRDLVLERAGDERGQEVTPCALGTLGASHNLCPVGCCPARAPRPAAAGADSPYA
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
What are the official names of this protein?
Coproporphyrin III ferrochelatase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_SHIBS
Sequence: MLNSFKLSLQYILPKLWLTRLAGWGASKRAGWLTKLVIDLFVKYYKVDMKEAQKPDTASYRTFNEFFVRPLRDEVRPIDTDPNVLVMPADGVISQLGKIEEDKILQAKGHNYSLEALLAGNYLMADLFRNGTFVTTYLSPRDYHRVHMPCNGILREMIYVPGDLFSVNHLTAQNVPNLFARNERVICLFDTEFGPMAQILVGATIVGSIETVWAGTITPPREGIIKRWTWPAGENDGSVALLKGQEMGRFKLGSTVINLFAPGKVNLVEQLESLSVTKIGQPLAVSTETFVTPDAEPAPLPAEEIEAEHDASPLVDDKKDQV
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: KAX2B_CENEL
Sequence: TIINVKCTSPKQCLLPCKEIYGIHAGAKCMNGKCKCYKI
What is the function of this protein?
Blocks Kv1. 3/KCNA3 voltage-gated potassium channels of human T-lymphocytes (Kd=0. 98 nM).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 2.11, Toxin Ce4.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 02 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LIN25_CAEEL
Sequence: MNSIKIDSSTKIVIEYIDKLRNCSNEKRQKVSSVIRPVDFPGISTQQLCDILIRFAYNGTYIDDVFRDHLLKLVVDKSITWNQVIHSVINTKTDRIYSKCLQCELIREMVNYVQIKSFSDKLHADELISIMKPTVFFLAQLIQDVLSDEDELEMIQIEYGDVRKAYYKPLEALSAFIHDDLCSSLLAFSEASEITHQLELCRDSFSKLRSPDKSATTLVEMLIERHIEKCKPVKFQYIPEGIALFDLKNPSIRILIPIFACFKNHESSKLMAETIQTFAEIMRFYGPDVIFDILHGAILLKCEESMDLLHFPKQHRADFRWQSTTFFYKKLPQIIEYLIRSEKLTVAEVQFGLEKALTDLSMMFDAADVAWQNASFLTLLNELEPVLGKTITDPLRLRRREHMKTNDQLLPFADTDNQLIENTDIDKLLNAVKEVMNLQFGQTEEFSKLFVDKVKTGQTDNFDAITSILITEGRLMEVGKAFVLKNVEAQRSSAVGVNERIQIFDDTFILLSRILIKNPSVSINMFVNGGPGKSDAEQTMFYKWSMRYVKRVAKHRDPEPKDETEYIALRKEVEMLMRLANAEVGIEDDLENDVEEEMPEVQEPNIETQNVDEISIPDPLHLLIENDPTVTAESKETEEVKFNPEGVEQMDTNEKPAEISDSLIEPTLLEEPKDILENIIVPIIKVEAPKPDSPIKKKKDPDVTWHEVHCPLPRISRRTARAYLAQMKEGIPFWKTDDPNLNIGSILAAIPRLGQLLVDEHEEKRNRIDRKSAEENMTNILHAIESMPSLFLCLLEWLDCEPESGARTSLAFTINLSLERYLAVSTHGINYMKWIFIKSTVQQMIDELVDKSPAFPEVTCTAFSTARRFCPFVGRNENPDQLKLKHAWYYMRQQAWASPHALRLLEHANTAREYDVWSHIYISKTIKSGCGDIMTSSVDMIFSFLMLDDLNSIIRIHESLMAFWLSEDAGQCQADGRFDPLSIRVVIRLMTQVLLIAEWTLDRLLNEDPAFVERLNLKEVKAPEPEDPDKREKWIFLLRSMLERTINRFFKIVRKGLLSNVVNTIIQLLKSIAGSADCKAKRLLVKRIPPDLIFQLAYIEPSSVDYSLMNIYCDPDNKEHTQTKIMFLCALRRSQSFSF
What is the function of this protein?
Participates in the inductive signaling pathway downstream of let-60 Ras and the RAF/MAP kinase cascade to regulate specification and differentiation of many cell types (PubMed:11063686).  Positively regulates the fate of vulval precursor cells (PubMed:3996896, PubMed:7867931, PubMed:9806929).  Required for induction of the P12 and excretory duct cell fates.  In males, it is also required for proper formation of spicules.  Does not function in the signaling pathway that promotes exit from pachytene (PubMed:11063686).  Plays a role in responses to M. nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855).
What are the official names of this protein?
Protein lin-25, Abnormal cell lineage protein 25.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: PRP39_SCHPO
Sequence: MDYGDIYIAEETEWDKYNRQINKNPDDFDAWEGLVRASEHLEGGVGRNSSKQAINTLRSVYDRFLGKYPLLFGYWKKYADFEFFVAGAEASEHIYERGIAGIPHSVDLWTNYCAFKMETNGDANEVRELFMQGANMVGLDFLSHPFWDKYLEFEERQERPDNVFQLLERLIHIPLHQYARYFERFVQVSQSQPIQQLLPPDVLASIRADVTREPAKVVSAGSKQITVERGELEIEREMRARIYNIHLQIFQKVQLETAKRWTFESEIKRPYFHVKELDEAQLVNWRKYLDFEEVEGDFQRICHLYERCLITCALYDEFWFRYARWMSAQPDHLNDVSIIYERASCIFASISRPGIRVQYALFEESQGNIASAKAIYQSILTQLPGNLEAVLGWVGLERRNAPNYDLTNAHAVLRSIINEGKCNTGITEVLITEDIKLVWKIEGDIELARNMFLQNAPALLDCRHFWISFLRFELEQPLNSKNYTEHHARVSNVMEMIRNKTRLPPRTIMDLTKLYMEYLCHQSNDPSVLQEYLLIDRDVFGPFSVRESHWKKLDEGQDLKQVSTRLLSTNGHPGISVNEAKIKSGESPYEKYYRLQGVVETVTSGVAANGSS
What is the function of this protein?
Function prior to stable branch point recognition by the U1 snRNP particle to facilitate or stabilize the U1 snRNP/5'-splice site interaction.  Has a direct role in the assembly or function of a catalytically active spliceosome (By similarity).
What are the official names of this protein?
Pre-mRNA-processing factor 39.
What is the protein family that this protein belongs to?
Belongs to the PRP39 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: H4_RAT
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Stimulates osteogenesis and hematopoiesis.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. SUBCELLULAR LOCATION: [Osteogenic growth peptide]: Secreted. Note=Osteogenic growth peptide is secreted by a mechanism independent from a hydrophobic signal sequence. The mature peptide may be imported into secretory lysosomes by an ABCA1-related protein.
Protein: YQGF_BIFLS
Sequence: MVWLGVDLGNARVGLALSDPELTFAHPAGNIHVAGDYFFAIDEVLNVIEDEHVDHVIVGLPLQMDGTEGKSAKKARRWAANLEKRLQAESEDSDSTEYQIPQVSLIDERLTTVSAHRQLFEAHKASNKHRPVVDQQSAVVILQTALDRTRE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLHL7_CHICK
Sequence: MAAPGSEKSSKKKTEKKLAAREEAKLLAGFMGVMNSMRKQRTLCDVILMVQERRIPAHRVVLASASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPYMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVEGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSRRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKMNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWIANSKVRAFPVTSCLICVVDTCGANEETLET
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.  The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins.  Probably mediates 'Lys-48'-linked ubiquitination (By similarity).
What are the official names of this protein?
Kelch-like protein 7.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MTMRC_PONAB
Sequence: MLGKGVVGGGGGTKGPKPSFVSYVRPEEIHTNEKEVTEKEVTLHLLPGEQLLCEASTVLKYVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGVFDEKKKTLFGQLKKYPGKLIIHCKDFRVFQFCLGYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGIYKTIHRSPYEIVKTEDVSSNFLSLQEIQTAYSKFKQLFLTDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDANMGREGQDAQSKPLNLLTVWDWSVQFEPKAQTLLKNPLYVEKPKLDKGQRKGMRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVATMSKLLEMMEEVQSLQEKIDERHHSQQVPQAEAPCLLRNSARLSSLFPFALLQRHSSKPVLPTSGWKALGDEDDLAKREDEFVDLGDV
What is the function of this protein?
Acts as an adapter for the myotubularin-related phosphatases.  Regulates phosphatase MTM1 protein stability and possibly its intracellular location.  By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis.
What are the official names of this protein?
Myotubularin-related protein 12, Inactive phosphatidylinositol 3-phosphatase 12.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Sarcoplasmic reticulum. Cytoplasm, myofibril, sarcomere. Note=Localizes to punctate vesicles when associated with MTM1 (By similarity). Localizes to triads, a structure formed by a T tubule and two sarcoplasmic reticulum terminal cisterna. In skeletal muscles, co-localizes with MTM1 in the sarcomere. Partially localizes to the sarcoplasmic reticulum in skeletal muscles (By similarity).
Protein: 14332_CAEEL
Sequence: MSDGKEELVNRAKLAEQAERYDDMAASMKKVTELGAELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEGSEKKQQMAKEYREKVEKELRDICQDVLNLLDKFLIPKAGAAESKVFYLKMKGDYYRYLAEVASGDDRNSVVEKSQQSYQEAFDIAKDKMQPTHPIRLGLALNFSVFFYEILNAPDKACQLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDAATDDTDANETEGGN
What is the function of this protein?
Required for extension of lifespan by sir-2. 1 (PubMed:16777605).  Required to modulate lifespan, in concert with hcf-1, acting redundantly with 14-3-3-like protein par-5 (PubMed:21909281).  Promotes nuclear export of yap-1 (PubMed:23396260).  Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm (PubMed:21531333).
What are the official names of this protein?
14-3-3-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ISPD_TOLAT
Sequence: MQTFTAVVPAAGRGSRMQANKPKQYLHLGDKTIIEHTLTRLLAHPQIEKIVVVIADDDHYFSSLPLANHPRIEVTLGGPERAISVLNGLSSVETDWVLVHDAARPCITQSDLDALMAAAELGEDGAILAVPVKDTMKRSDSQQRIEETVERGHLWHALTPQMFPTQQLADAIDAGLTQSIVLTDEASAMERAGFKPLLVAGRSDNIKVTRPEDLALAAFILQQQELE
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: RS7_DICT6
Sequence: MPRRGPVTPREIPPDPVYNSVLVQKLINKVMLDGKKSIAEKIVYGAMEIIREKTKQDPLVVLEKAVQNVTPLLEVRPRRVGGATYQVPIEVPPRRGLSLALRWIVRAARERKGMPMKERLALEILDALNNTGGAIKKRDEMHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: PTH_SERP5
Sequence: MSSIKLIVGLANPGAEYAQTRHNAGAWYVDLLAQRHNQQLKEESKFYGYTARLNLAGNDVRLLVPTTFMNLSGKAVLAMANFYRIEPDEILVAHDELDIPPGVAKIKLGGGNGGHNGLKDIQSKFGNNPNFYRLRIGIGHPGDKNKVVGFVLGKPPASEQKMIDEAIDEAARCTEILLTDGLEKTVRRLHSFKAQA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_PSYA2
Sequence: MGKVIGIDLGTTNSCVAVMEGDKVKIIENAEGTRTTPSIVAYKDDEILVGQSAKRQAVTNPNNTLFAIKRLIGRRFDDKVVQKDIGMVPYKIAKADNGDAWVEINGKKLAPPQVSAEILKKMKKTAEDYLGEAVTEAVVTVPAYFNDSQRQATKDAGKIAGLDVKRIINEPTAAALAYGMDKKQGDSTVAVYDLGGGTFDVSIIEIADVDGEQQFEVLATNGDTFLGGEDFDSALIDFLVAEFKKDQDVNLKGDSLAMQRLKEAAEKAKIELSSAQSTEVNLPYITADSSGPKHLVVTISRSKLESLTEELVQRTMGPCKMALEDAGIKIGDIDDVILVGGQTRMPLVQQKVQEFFGQEPRKDVNPDEAVAAGAAIQGAVLSGEKTDVLLLDVTPLTLGIETMGGILTPIIEKNTMIPTKKSQVFSTAEDNQPAVSIQVYQGERKIANQNKQLGRFDLTDIPPAPRGLPQIEVSFDINADGIMNISATDKGTGKAQSIQIKADSGLSDEEVEQMIRDAEANAAEDEKFANLAQVRNEADGRIHAVQKALKDAADKVSDDEKSSVETAISELEAAAKEDDHDDIKAKLEALDNAFLPVSQKIYADAGAGSEGMDPNQFQQGADNAGENNQADDDVVDAEFTEVEDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CD276_HUMAN
Sequence: MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA
What is the function of this protein?
May participate in the regulation of T-cell-mediated immune response.  May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells.  May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces.  Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.  Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses.  Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
What are the official names of this protein?
CD276 antigen, 4Ig-B7-H3, B7 homolog 3, B7-H3, Costimulatory molecule.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. BTN/MOG family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RSGI6_ACET2
Sequence: MIVGKVLDMDEKTAIIMTDDFAFLNVVRTSEMAVGKKVKVLDSDIIKPKNSLRRYLPVAAVAACFVIVLSFVLMFINGNTARKNIYAYVGIDINPSIELWINYNNKIAEAKALNGDAETVLEGLELKEKTVAEAVNEIVQKSMELGFISREKENIILISTACDLKAGEGSENKDVQNKIGQLFDDVNKAVSDLKNSGITTRILNLTLEERESSKEENISMGRYAVYLKAKEQNVNLTIDEIKDADLLELIAKVGIDNENVPEDIVTEDKDNLDAINTGPAESAVPEVTETLPATSTPGRTEGNTATGSVDSTPALSKNETPGKTETPGRTFNTPAKSSLGQSSTPKPVSPVQTATATKGIGTLTPRNSPTPVIPSTGIQWIDQANERINEIRKRNVQIKVVDSSNKPIENAYVEAVLTNHAFGFGTAITRRAMYDSNYTKFIKDHFNWAVFENESKWYTNEPSMGIITYDDADYLYEFCRSNGIKVRGHCIFWEAEEWQPAWVRSLDPFTLRFAVDNRLNSAVGHFKGKFEHWDVNNEMIHGNFFKSRLGESIWPYMFNRAREIDPNAKYFVNNNITTLKEADDCVALVNWLRSQGVRVDGVGVHGHFGDSVDRNLLKGILDKLSVLNLPIWITEYDSVTPDEYRRADNLENLYRTAFSHPSVEGIVMWGFWERVHWRGRDASIVNDNWTLNEAGRRFESLMNEWTTRAYGSTDGSGSFGFRGFYGTYRITVTVPGKGKYNYTLNLNRGSGTLQTTYRIP
What is the function of this protein?
Anti-sigma factor for SigI6.  Negatively regulates SigI6 activity through direct interaction.  Binding of the polysaccharide substrate to the extracellular C-terminal sensing domain of RsgI6 may induce a conformational change in its N-terminal cytoplasmic region, leading to the release and activation of SigI6 (By similarity).  Binds to and hydrolyzes insoluble and soluble xylan substrates.  Has low enzymatic activity (PubMed:20820855).
What are the official names of this protein?
Anti-sigma-I factor RsgI6, Endo-1,4-beta-xylanase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the glycosyl hydrolase 10 (cellulase F) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.