PharMolix/UniProtQA huggingface dataset:
Protein: CXCR2_MOUSE
Sequence: MGEFKVDKFNIEDFFSGDLDIFNYSSGMPSILPDAVPCHSENLEINSYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNGWTFGSTLCKIFSYVKEVTFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCIAMWLLSVILALPILILRNPVKVNLSTLVCYEDVGNNTSRLRVVLRILPQTFGFLVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLVFLLCWLPYNLVLFTDTLMRTKLIKETCERRDDIDKALNATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMATYGLVSKEFLAKEGRPSFVSSSSANTSTTL
What is the function of this protein?
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor.  Binding of IL-8 to the receptor causes activation of neutrophils.  This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.  Binds to IL-8 with high affinity.  Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
What are the official names of this protein?
C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8R B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: METXA_METPE
Sequence: MQRGSVGISTTSTFTLATPLLLESGASLFSVQIAYETYGTLNHDKSNAILVCHALTGDAHAAGHHGDESRPGWWDGVIGPGKAFDTDKYFVICSNVLGGCKGTTGPASQNPDTGKPYGTSFPVVTIRDMVNVQKALIDHLGISQLFAVAGGSMGGMQVLQWMVSYPSMVRKAIAIAATGSSTPQQIAFNEVGRKAITADPAWCGGDYYGKEHPVKGLSLARMVAHITYLSDASMHTKFGRALQDREFRGFDFDTEFQVESYLHHQGTSFTKRFDANSYLYLTKAVDYFDLSVDDSLISGFAPTKATVLIISVTSDWLYPPYQSQEIVSALSANECDVHYCELRSQFGHDAFLIETGQLNYSISRFLDHTLVRDVMNTQVPVISEQSTIAVAARMMITQGVNHLPVLAPDQSLVGIVTSWDIANAVACGYTSLDQIMSSQVITTTGDETIEVAASRMEQHRISALPVIDQAQHVIGLISSDGLSKLIGRGP
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_NITHX
Sequence: MTKRNEAKYKIDRRMGQNIWGRPKSPVNKREYGPGQHGQRRKGKLSDFGTQLRAKQKLKGYYANISERQFYAIYVEATRLKGDSGENLIGLLERRLDTVVYRAKFVPTMFAARQFINHGHVKVNGRRVNIPSYKLKVGDAIEVKDASKQLALVLEANQLAERDVPDFIDADHNKQTAKFVRIPHLADVPFAVQMEPHLIVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: LEXA_CUPNE
Sequence: MATLTPRQQQIFDLIRDTIRNTGFPPTRAEIAAEFGFSSPNSAEEHLRALARKGVIELTPGASRGIRLKVTRSDSERPDQFSLPMPGVLQLTLPLVGRVAAGSPILAAEHIDRQYQVDASVFDERPDYLLRVRGLSMRDAGILDGDLLAVKKASEAANGKVVVARLGDDVTVKRLKKRGDTIELIAENPDFQNIVLHAGRDEFSLEGIAVGLIRSSGF
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: SYT_SHELP
Sequence: MPVITLPDGSKREFANAVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDVDLAIITVKDDEGVEILRHSCAHLLGHAIKQMWPETKMAIGPVIDNGFYYDVDLDHKLTEEDVAELEKRMLALAKTNYDVVKRVVSWQEARDTFESRGESYKMAILDENISKDDQPALYHHEEYTDMCRGPHVPNMKFCHHFKLMSVAGAYWRGNSDNKMLQRIYGTAWADKKALKAHLTRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSLFLELERFIRQKLGQYTYQEVKGPLMMDRVLWERSGHWDKYSEAMFTTHSENREYAVKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQQEVSGCIKMVYDTYATFGFHDIVVKLSTRPEKRIGDDAMWDRAEQALMDALKANDIEYEILPGEGAFYGPKIEFTLHDCLDRAWQCGTVQLDYALPGRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGKFPTWLAPVQAVVMNITDKQSEYVDEVVKLFKDQGIRASKDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENREVAVRTRDGVDLGKIKIDQFAAMVKEQISLRSLNLLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCAF1_CHICK
Sequence: MDNTDEPQKKVFKARKTMRASDRQQLEAVYKAKEDLLKTTEVKLLNGKHENGDSDLNSPLSNTDCTEDKREVNGLVDSNEISEIKRPESRAESVVSDLEPKPLSPVNVTREQDTDVALVCEAENRVLGSNKVNFHEENNIKNRLDQRESDTPSGENKSNCDNSFSPEEKGKTNDITIISNSPVEEKKKAGEIIVEDTVGEEAISSSMETDQEPKNERDGTAGLSETVVEKAVDESSESILENTDSMEADEIIPILEKLAPAEDEMSCFSKSALLPVDDTAPDLEEKMDNCLSSPLKQESNESLPKEAFLVLSDEEDPCDEREHAEVILPNKSGLPEEVEKSEEEDKEREVVHKEEEKHTERGEVSRRKRSKSEDMDSVHSKRRRFVGEEDYEAEFQVKITARRDVDQKLEKVIQRVLEEKLAALQCAVFDKTLADLKMRIEKVECNKRHKTVLTELQAKITRLTKRFGAAKEDMKKKQENTPNPSLSSGKAASSTANANNLTYRNITTVRQMLESKRNVGDSKPATLQAPVSAAPASSLAAPQTPASGHPKPQTPVTSSPLTTTVISTANTATVVGTSQVPSGSTQPMSVSLQSLPVILHVPVAVSSQPQLLQGHAGTLVTNQQSGSVEFISVQSSSTVGSLTKTAVSLASTNTTKPNNSPSVSSPGVQRNSPASAGSVRTTLAVQAVSTTHPVAQTTRTSLPTVGTSGLHNSTSSRGPIHMKIPLSAFNSTAPTEPPTITAPRVENQTSRPPTDSSANKRTAEGPTQSVKVTGSDSGGVIDLTLDDEDDVSSQAEAKKQNQTASTAQSIPTQPLSRPLPPLQPNPLQQTGVPTSGPSQTTIHVLPTAPTTVNVTHRPVTQTAAKLPIPRTPTNHQVVYTTIPAPPAQNSVRGAVMPSPSLRPVNPQTGSMTVRMPQTTAYVVNNGLTLGSGAPQLTVHHRPPQVHAEPPRPVHPAPLPEAPQPPRLPPEAANTSLPQKPQLKLARVQSQNGIVLSWSVIEVDRSCASVDSYHLYAYHEDPSATMPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQSTDVISSQSS
What is the function of this protein?
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation.  Can both act as an activator or a repressor depending on the context.  Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity.  May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity).
What are the official names of this protein?
Activating transcription factor 7-interacting protein 1, MBD1-containing chromatin-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the MCAF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCSH_PROM1
Sequence: MAFSFPDHFRFADSHEYAFADDALVRIGISEFAVDQLGDIVFVDLPEEGTAIAKGESFGSVESVKAVEDMYAPVSGEIVHRNNSVLASPEELQNDPHGEGWLLIIRPDNPAQLTELMDSETYSKKISA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: ACTP_ECOSM
Sequence: MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSEAMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATEREELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMLGGWLGLITAVVLMILGPTIWVQILGHEKAIFPYEYPALFSISVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSMJ_HYDCU
Sequence: MQTSSFPIVIDDHLLPDKAHALAQQLNLPLISATEAEKSAPLMKLGWWQDGKKSGDHTNEIDYKLALFPPSTGPVCIDFVSGKKNHRRQFGGGKGQPLARAVLAAEHPTIIDATAGMGGDAFVFASLGCQVTMIERSPIIAALLSDALNRAQQTGVAEDIQEIVKRLRLINDDATQYLTTQAPICDVIYLDPMYPEKKKTAATKKEMQALQHLVGPDIDSETLLAAALHVAQKRVVVKRPKNAPALTGIQPNASIQSPNTRYDIYAIKALKAAGKL
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCH1_CANGA
Sequence: MALSSIEHYLSYHLRVLLPQVLSSKSSHNIAYIFALFAAITSGFVSLISLYAQPWQEHLSYSSWQINMIVTVINMGMYLTPPILGIIADIHGPITLSLSSVLGFIPSYAYLAYTFHRDHSFTNESDGSFTPTLVCFFIIGVATSGLYFSALITCAKLFPGTKLLSISIPTTCYGLSSLIGSQFLRVKYFHPVDYPYLDLGRVFKAFAWIYTVIGVMIWIATSKVAQIQHEADIMEEQDRMAEPSDNDVENHYDDNEQSRLLHATHAQQMTLMKVFRDPVLYIFGATIFCALGPLEMFIANMGSLTNVLAGGHEPAMSSALLSIYALTSTLTRLGTGLTVDYFNKRQLSVKWILLLFLVVGLVTQGKIYMLSMSSLDHSHMVTINRKLFYIGIMQGIAYGGLFTIYPTITLMVWGEKMFGTAYGTLMIAPALGSALSCLIYADVYDSECANSTTRSCIAPVYETTALEFCAAILLTVVVTVLWRKRRTHI
What is the function of this protein?
Probable transporter.
What are the official names of this protein?
Probable transporter MCH1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: Y1899_MYCTO
Sequence: MAAMRAHARRRHPHALMSRAAGLPRLSWFAGLTWFAGGSTGAGCAAHPALAGLTAGARCPAYAAISASTARPAATALPAVAASTARPAATAGTTPATGASGSARPTDAAGMADLARPGVVATHAVRTLGTTGSRAIGLCPSQPLDCPRSPQATLNLGSMGRSLDGPQWRRARVRLCGRWWRRSNTTRGASPRPPSTCRGDNVSMIELEVHQADVTKLELDAITNAANTRLRHAGGVAAAIARAGGPELQRESTEKAPIGLGEAVETTAGDMPARYVIHAATMELGGPTSGEIITAATAATLRKADELGCRSLALVAFGTGVGGFPLDDAARLMVGAVRRHRPGSLQRVVFAVHGDAAERAFSAAIQAGEDTARR
What are the official names of this protein?
Uncharacterized protein MT1950.
Protein: BLRF2_EBVB9
Sequence: MSAPRKVRLPSVKAVDMSMEDMAARLARLESENKALKQQVLRGGACASSTSVPSAPVPPPEPLTARQREVMITQATGRLASQAMKKIEDKVRKSVDGVTTRNEMENILQNLTLRIQVSMLGAKGQPSPGEGTRPRESNDPNATRRARSRSRGREAKKVQISD
What is the function of this protein?
Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA.  Acts by inhibiting CGAS-DNA phase separation: directly binds double-stranded DNA (dsDNA) in a length dependent but sequence independent manner and is able to form DNA-induced phase separation in infected cells.  DNA phase separation of ORF52 mediates disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity.
What are the official names of this protein?
Tegument protein BLRF2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae BLRF2 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm.
Protein: PSBH_AMBTC
Sequence: MVTQSVEDSSRSGPRRTIVGDLLKPLNSEYGKVAPGWGTTPFMGVAMALFAIFLSIILEIYNSSVLLDGISVS
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H, Photosystem II 10 kDa phosphoprotein.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: POLG_LIVNO
Sequence: SRCTHLENRDFVTGTQGTTRVTLVLELGGCVTITAEGKPSMDVWLDAIYQESPAKTREYCLHAKLSETKVAARCPTMGPAVLTEERQIGTVCKRDQSDRGWGNHCGLFGKGSIVACVKAACEAKKKATGYVYDANKIVYTVKVEPHTGDYVAANETHKGRKTATFTVSSEKTILTLGEYGDVSLLCRVASGVDLAQTIILELDKTAEHLPTAWQVHRDWFNDLALPWKHDGNPHWNNAERLVEFGAPHAVKMDVYNLGDQTGVLLKALAGVPVAHIEGNKYHLKSGHVTCEVGLEKLKMKGLTYTMCDKSKFAWKRTPTDSGHDTVVMEVTFSGSKPCRIPVRAVAHGSPDVNVAMLITPNPTIENDGGGFIEMQLPPGDNIIYVGELSHQWFQTGSSIGRVFQTTRKGIERLTVIGEHAWDFGSAGGFFSSIGKAVHTVLGGAFNSIFGGVGFLPKLLMGVALAWLGLNTRNPTMSMSFLMAGGLVLAMTLGVGA
What is the function of this protein?
Binds to host cell surface receptor and mediates fusion between viral and cellular membranes.  Envelope protein is synthesized in the endoplasmic reticulum in the form of heterodimer with protein prM.  They play a role in virion budding in the ER, and the newly formed immature particle is covered with 60 spikes composed of heterodimer between precursor prM and envelope protein E.  The virion is transported to the Golgi apparatus where the low pH causes dissociation of PrM-E heterodimers and formation of E homodimers.  prM-E cleavage is ineficient, and many virions are only partially matured.  These uncleaved prM would play a role in immune evasion.
What are the official names of this protein?
Genome polyprotein.
What are the subcellular locations of this protein?
[Envelope protein E]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SLYA_KLEP3
Sequence: MESPLGSDLARLVRVWRALIDHRLKPLELTQTHWVTLHNIHQLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCSSDRRAKRIKLTEKAEPLINEMEEVIGKTRDEILSGVSKQEVETLLHLIRKLEQNILDLQAKD
What is the function of this protein?
Transcription regulator that can specifically activate or repress expression of target genes.
What are the official names of this protein?
Transcriptional regulator SlyA.
What is the protein family that this protein belongs to?
Belongs to the SlyA family.
Protein: CF20D_RAT
Sequence: MFKNEYQGGAFVEIFSAQGKNPGAKWKILGSPSVIWKEFDKEVKSFVFVLEGSSQTNRIQLPKENKQILGLIQRFLVLQIYVPLGQDFSTELLITDLGNIKRRLYLSTVHKEVSSTPLHAKIPLFMIKRKIWCNLCIDLVAFTSEIFKGAVFQSLDGIIVSANCKLRKIFTLKFKPRETADRDDEPADIIPRSCQLATDVPHVTQLLNMTKLRQTEIKFGGHPLRSAESDQFISSRAGSVRSSKSQDVCHIAFGSRVLGPPPPSGRRNNLRLSAETVRSIGYKNNQSCQQPAEEKHVNSADTSALLIPLSEQQGEKGSSHPVKQTTPLPASLPTPYPHPPRDPSADKGSSRRGLGLRSSSGSRTEARCGSSSGNSRSEEDVAMAANNLTQLTTEPVRASTPEPPAAEPPDEWIFPESSGPPSGAAGSSSSLLLDGDSRTASHLWLETSKDSDPDQAEGTQMAPKDIFTFSSRPRSAPHGKSHDLSPTGCPCILDPKEDSRVTKGDTELEDDFYGSDSSEEEYNWRNYQPSQMSESELQMLASLRRQQNEDLEDTGAPHGLSASQVDNCNVSISTSSDDTTTWNSCLPPPVNQGRHYQKEMNPPSPSNPRDWLNMLSPPIVPPSQQPLEQSLDSSASLSVQGGALLLTQPHLASCAVGC
What are the official names of this protein?
Protein CFAP20DC.
Protein: DCUP_HAES1
Sequence: MTVLKNERYLKALLREPVDMTPVWMMRQAGRYLPEYKATRAKAGDFMSLCRNADLACEVTLQPLRRYDLDAAILFSDILTIPDAMGLGLSFGVGEGPKFARPVENKSAVQNLPIPDPEQELQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMMYSEPKILHLLLDKLADAVILYLNAQINAGVQAVMVFDTWGGVLGHREYLDFSLQYMHKIVDGLIRENDGYKVPVTLFTKGGGLWLEAMASTGCDALGLDWTVNLAEAKARVGHKVALQGNMDPSVLYASPARIEQEVQQILADFGQGSGHVFNLGHGIHQDVPEISPKVFVDAVHQYSVSYHQ
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAR1B_ARATH
Sequence: MFLFDWFYGILASLGLWQKEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSEELSIGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYDKERFAESKRELDALLSDEALATVPFLILGNKIDIPYAASEDELRYHLGLTNFTTGKGKVTLGDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYIN
What is the function of this protein?
Involved in transport from the endoplasmic reticulum to the Golgi apparatus.
What are the official names of this protein?
GTP-binding protein SAR1B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. SAR1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus.
Protein: BIOB_BRUA4
Sequence: MLNMVQSNPKGVEKTASKSEQDAWTLASARLLYDLPFNDLLFEAQNVHRANFDPNRVQLSKLLNIKTGGCPEDCGYCSQSAHHASGLKASKLMSLDTVLEEAQKAKDSGATRYCMGAAWRSPKPRDEPAIAEMVKQVKALGLETCMTLGMLSPDQAQTFAEAGLDYYNHNIDTSERFYPQVITTRSFDDRLETLAHVREAGIKVCSGGILGLGETEDDRIDMLVTLANLPTPPESVPINMLIPMPGSRLEKASPVDPIAFVRIIALARLMMPQSHVRLTAGRNSMSDEMQALCFFAGANSIFIGDTLLTAANPGEDRDTSLMRRLGLTADTLDNHA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: TILS_TREDE
Sequence: MCKIYLMAKSFLKDVLLGFSSLCDRTAAPLRLLLAVSGGADSMAMLSAFLELKSDINAEIFVLTVNHNIRPEKETLGDAQFVLDFCNDKCPCILAEIPKNTVFDEAKNRKTGIEDAARFLRYNEFEKAADSLNADYILTAHNKNDNYETVLMRLFQGSEPEALMGISPRRGRFIRPMLNISRSEIEEYLKEKNIPWREDATNLEASYLRNKVRHNLLPVLSICFDGWQSGLDKSLAKIKAQNDFVIASYKTKKEEWVLDKKEDCCRCKFLFFLSLDEALKLKFLQEGLILLKGKRRIPYSVFDDLMKLSDTKKIIFSGGFCIKKEGDEVLLFKAVTEEKTSEVFYSIWIDKPCSFDTPAGNFKALENDDGFFIVHESDKTCGIGPFKPPFCVRSRLFGDEIETSSGSKKSVKKIINEWNIDYENRNILPIIEEGGVVKGIYGAVFGKKNWYVVGDLGVKR
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNB_EDWI9
Sequence: MKDFLPFSKPAIGDEEIAAVSEVLRSGWITTGPQNQALEQEFCQATGARHAIAVCSATAGMHVTLMALGIGPGDEVITPSMTWVSTLNIITLLGATPVMIDVGRDTLMVTPEAIADAITPRTKAIIPVHFAGAPVDLDPIRALAQRQGIALIEDAAHAIGTAYRGEPIGQRGTAIFSFHAIKNVTCAEGGMVVTDDDRLAQQVRSLKFHGLGVDAYDRQTHGRAPQAEVVTPGYKYNLADINAAIARVQLAKLPELNARRARLAAYYLQQLAQHQLPFSPLNTPEWPHQHAWHLFIIRCDEARSGVDRDRLMQALKERNIGSGLHFRAAHTQKYYRESYPQLRLAQTEWNSQRICSLPLFPDMTEADVDRVIAALKEIIEQ
What is the function of this protein?
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase, UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase, UDP-Ara4O aminotransferase, UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
Protein: RL18_FRATH
Sequence: MDKKTARLSRSKRTRIKLRELGHTRLCVYRTPRHVYAQVISGDGSTVLVAASTVEKDVKAKCKYTGNVESAAIVGEIIADRCKEKGISQVAFDRSGYKYHGRVKALVEAAREHGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TRUA_VIBC1
Sequence: MRIALGIEYNGTNYFGWQRQREVKSVQEELEKALSVVANHPVEVQCAGRTDAGVHGTGQVVHFDTNVSRKMVAWTMGANANMPSDIAVRWAVEVNDDFHARFSATARRYRYIIFNHALRPGILNSGVSHYHGELDEKKMHEAGQYLLGENDFSSFRAAHCQSLSPCRNMMHLNVTRHGDYIVIDIKANAFVHHMVRNITGSLIKVGRGEEKPEWIKSLLEAKDRKLAGATAKAEGLYLVDVDYPEEFGLPRVPIGPLFLPDNLN
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: AHBD_METBF
Sequence: MIAMTNAPRLIAWELTAGCNLNCVHCRGASTSSVPAGELTTDEAKHFIDEVASIGKPILILSGGEPLTRPDVFEIARYGTDAGLRVVLATNGTLLTPEIVEKLRAAGVQRLSVSIDGANAETHDNFRGMPGAFERTLAGIEVLRKADFPFQINTTVSKRNLEEITKTFELAKELGAVAYHVFFLVPTGRGDESDEVSPADYERILHWFYEMQKESKIQLKATCAPHYFRIMRQQAKKEGIEISVKTHGYEAMTKGCLGGTGFCFVSSVGKVFPCGYLPVLAGNIREQPFREIWENAEVFRKLRDPEELKGKCGICEYKKVCAGCRARAYAATGDYLEEEPYCIYRPGKK
What is the function of this protein?
Involved in siroheme-dependent heme b biosynthesis.  Catalyzes the conversion of Fe-coproporphyrin III into heme by the oxidative decarboxylation of two propionate side chains.
What are the official names of this protein?
AdoMet-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily.
Protein: DPO3_STAAS
Sequence: MAMTEQQKFKVLADQIKISNQLDAEILNSGELTRIDVSNKNRTWEFHITLPQFLAHEDYLLFINAIEQEFKDIANVTCRFTVTNGTNQDEHAIKYFGHCIDQTALSPKVKGQLKQKKLIMSGKVLKVMVSNDIERNHFDKACNGSLIKAFRNCGFDIDKIIFETNDNDQEQNLASLEAHIQEEDEQSARLATEKLEKMKAEKAKQQDNNESAVDKCQIGKPIQIENIKPIESIIEEEFKVAIEGVIFDINLKELKSGRHIVEIKVTDYTDSLVLKMFTRKNKDDLEHFKALSVGKWVRAQGRIEEDTFIRDLVMMMSDIEEIKKATKKDKAEEKRVEFHLHTAMSQMDGIPNIGAYVKQAADWGHPAIAVTDHNVVQAFPDAHAAAEKHGIKMIYGMEGMLVDDGVPIAYKPQDVVLKDATYVVFDVETTGLSNQYDKIIELAAVKVHNGEIIDKFERFSNPHERLSETIINLTHITDDMLVDAPEIEEVLTEFKEWVGDAIFVAHNASFDMGFIDTGYERLGFGPSTNGVIDTLELSRTINTEYGKHGLNFLAKKYGVELTQHHRAIYDTEATAYIFIKMVQQMKELGVLNHNEINKKLSNEDAYKRARPSHVTLIVQNQQGLKNLFKIVSASLVKYFYRTPRIPRSLLDEYREGLLVGTACDEGELFTAVMQKDQSQVEKIAKYYDFIEIQPPALYQDLIDRELIRDTETLHEIYQRLIHAGDTAGIPVIATGNAHYLFEHDGIARKILIASQPGNPLNRSTLPEAHFRTTDEMLNEFHFLGEEKAHEIVVKNTNELADRIERVVPIKDELYTPRMEGANEEIRELSYANARKLYGEDLPQIVIDRLEKELKSIIGNGFAVIYLISQRLVKKSLDDGYLVGSRGSVGSSFVATMTEITEVNPLPPHYICPNCKTSEFFNDGSVGSGFDLPDKTCETCGAPLIKEGQDIPFETFLGFKGDKVPDIDLNFSGEYQPNAHNYTKVLFGEDKVFRAGTIGTVAEKTAFGYVKGYLNDQGIHKRGAEIDRLVKGCTGVKRTTGQHPGGIIVVPDYMDIYDFTPIQYPADDQNSAWMTTHFDFHSIHDNVLKLDILGHDDPTMIRMLQDLSGIDPKTIPVDDKEVMQIFSTPESLGVTEDEILCKTGTFGVPEFGTGFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIKTGICDLSSVIGCRDDIMVYLMYAGLEPSMAFKIMESVRKGKGLTEEMIETMKENEVPDWYLDSCLKIKYMFPKAHAAAYVLMAVRIAYFKVHHPLYYYASYFTIRASDFDLITMIKDKTSIRNTVKDMYSRYMDLGKKEKDVLTVLEIMNEMAHRGYRMQPISLEKSQAFEFIIEGDTLIPPFISVPGLGENVAKRIVEARDDGPFLSKEDLNKKAGLSQKIIEYLDELGSLPNLPDKAQLSIFDM
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSTC2_MOUSE
Sequence: MRTLSLLTLLALAALCLSDLTDAKPSGPESDKAFMSKQEGNKVVNRLRRYLGASVPSPDPLEPTREQCELNPACDELSDQYGLKTAYKRIYGITI
What is the function of this protein?
Constitutes 1-2% of the total bone protein.  It binds strongly to apatite and calcium.
What are the official names of this protein?
Osteocalcin-2, Bone Gla protein 2, BGP2, Gamma-carboxyglutamic acid-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the osteocalcin/matrix Gla protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: GSDM_VITXG
Sequence: MGLCSDPAITYLKRLGYNVVRLPREGIQPLHLLGQQRGTVEYLGSLEKLITQPPSEPPAITRDQAAAGINGQKTENLSFSIGINILKSVLAQFGAGAGIEAQYNQARKVRFEFSNVLADSVEPLAVGQFLKMAEVDADNPVLKQYVLGNGRLYVITQVIKSNEFTVAAEKSGGGSIQLDVPEIQKVVGGKLKVEASVSSQSTVTYKGEKQLVFGFKCFEIGVKNGEITLFASQPGAIAMALDAAGGVMPSDSALLDEGGLLDLEGF
What is the function of this protein?
Pore-forming protein that causes membrane permeabilization via a pyroptosis-like activity.  Makes ring-like pores when released.
What are the official names of this protein?
Gasdermin bGSDM, bGSDM, Bacterial gasdermin.
What is the protein family that this protein belongs to?
Belongs to the bacterial gasdermin family.
What are the subcellular locations of this protein?
[Gasdermin bGSDM]: Cytoplasm. SUBCELLULAR LOCATION: [Gasdermin bGSDM, N-terminus]: Cell inner membrane; Multi-pass membrane protein.