PharMolix/UniProtQA huggingface dataset:
Protein: DRTE_ASPCI
Sequence: MSFAFSKVEFEEVEFQTLDKLTLKARLYSAAKRGPALVMNPGYNCTKEISAPSAAAYFQSKGITCLIYDPRNCGQSDGTPRREIDPHRQVDDYLDAMTYMSGLDIVDPDQIGFWGVSFSASIALAAACYDPRAKCIITVSPWTFDFGITAAEAKDNFSRLVAEREAQALGNEPFYTAMVDEEGNNPIHVNVDWGDEVRAAVNEFVSLSADGFVPTVTFQSYYKLFTFSPYLSLKFLGDTPLMMVVPEHDTVCPVEQQVKLYDAVEGPKEIYHAEGKRHLNMLAEDKFFEPMMKPQVEFFFKVMRGEAI
What is the function of this protein?
Acyltransferase; part of the gene cluster that mediates the biosynthesis of various drimane-type sesquiterpene esters, compounds that exhibit diverse biological activities and are widely present in eukaryotes (PubMed:34468074).  The pathway begins with the synthesis of the backbone drimenol by the terpene cyclase drtB using farnesyl pyrophosphate (FPP) as substrate (PubMed:34468074).  The cytochrome P450 monooxygenase drtD is then responsible for the hydroxylations at C-6, C-9 and C-12, as well as the oxidation of hydroxyl groups at C-6 and C-11 to a ketone and an aldehyde, respectively (PubMed:34468074).  Then, the biosynthesis can go in two directions, either the hydroxylated drimenol is further hydroxylated at C-2 and C-3 by an enzyme(s) not associated with the drt cluster, or the FAD-binding oxidoreductase drtC further oxidizes C-11 or C-12 to form the butyrolactone ring (PubMed:34468074).  DrtB, drtD and drtC are solely responsible for the formation of the different drimane structures observed during drimane sesquiterpenes biosynthesis (PubMed:34468074).  The polyketide synthase drtA synthesizes different lengths (C6 and C8) of PKS chains, which are then oxidized to varying degrees by the short-chain dehydrogenase drtF (PubMed:34468074).  Finally, these PKS chains are transferred onto drimane sesquiterpenes by the acyltransferase drtE, forming the sesquiterpene esters (PubMed:34468074).  In addition to the different fatty acyl-CoA chains produced by drtA, drtE is also able to use cinnamoyl-CoA as a substrate (PubMed:34468074).
What are the official names of this protein?
Acyltransferase drtE, Drimane-type sesquiterpene ester biosynthesis cluster protein E, Polyketide transferase drtE.
What is the protein family that this protein belongs to?
Belongs to the polyketide transferase af380 family.
Protein: METE_PSEPW
Sequence: MALAHNLGFPRIGRDRELKKAQEAFWKGELDEAGLRKVGRDLRAAHWQAQKDAGIELLPVGDFAWYDQVLTHSLTFGVIPERFRGHDGAKPTLQTLFAMARGVATGRSANCCGGAHAQEMTKWFDTNYHYLVPEFTVDQQFALSWEQLFEEVDEAKALGHAAKPVVIGPLTYLWLGKAKGGDFDKLELLDRLLPVYDEILNRLAGQGVEWVQIDEPILVLDLPQEWKNAYERVYNILQRAPLKKLVATYFGGLEENLGLAANLPVDGLHIDLVRAPEQYPTILDRLPAYKILSLGLVNGRNVWACDLEKAVDVLRHAAERLGDRLWVAPSCSLLHSPVDLGREDQLDTELKSWLAFAVQKCQEVAVLAKAVNQPDAAEVAAALARSRAIQAGRASSPRIHKPAVQARVHAIKPGDSQRQSAFGQRIAKQRAGLNLPAYPTTTIGSFPQTPAIRLARQAFKQGKLTEADYVEAMHSEIRHAVQIQENLGLDVLVHGEAERNDMVEYFAEQLDGYVFTRFGWVQSYGSRCVKPAVIYGDLSRPEAMTVAWIRYAQGLTRKVMKGMLTGPVTMLMWSFPREDVSRETQARQLALAIRDEVLDLEAADIKIVQIDEAAFREGLPLRRSAWPAYLEWATEAFRLCASGVRDETQIHTHMCYSEFNDVIESIAAMDADVITIETSRSDMELLEAFEKFDYPNEIGPGVYDIHSPRVPSREEMVKLLRKAALRIPAERLWVNPDCGLKTRAWPETEAALVNMVAAARELRATA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: MTG16_MOUSE
Sequence: MSQASTTTLESGALLSGPRGLQYGSPAHRKEKAAAMPDSPAEVKTQPRSTPPSMPPPPPTSSQGATRPPSFTPHTHGEDGPATSLPHGRFHGCLKWSMVCLLMNGSSHSPTAIHGAPSTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHAKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASATSPVDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPDHLSKRSCTLSPAQRCSPSNGLPHPTPPPPPHYRLEDMAMAHHFRDSYRHPDPRELRERHRPLAIPGSRQEEVIDHRLTEREWAEEWKHLNSLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWIRCYSDSEEGKKGPTPISARSLNSCSGPEGSQLDVHRDFTPRTLSGYMPEEIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHKDWEKHHHVCGQSLQGPAAAVADPLPGQPDATASPSEAGSAGPSRPCSPGPPGPLDAAVPR
What is the function of this protein?
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes.  Can repress the expression of MMP7 in a ZBTB33-dependent manner.  Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway.  Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (By similarity).  Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:16407974).  Plays a role in granulocyte differentiation (PubMed:15231665).
What are the official names of this protein?
Protein CBFA2T3, Eight twenty one protein 2, MTG8-related protein 2, Protein ETO-2.
What is the protein family that this protein belongs to?
Belongs to the CBFA2T family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Golgi apparatus membrane.
Protein: KN14S_ARATH
Sequence: MERDQHQEICNDGGLLCESKEVSVNNHNSDAVEESEDTITSGNQEVSPANGPTLPILQKIIDCSDKIKILKDEHALVSNQVQEIKNCSLVEPEISRALQLLTTKLGALEKQYLEESSERKRLYNEVIELKGNIRVFCRCRPLNQAEIANGCASVAEFDTTQENELQILSSDSSKKHFKFDHVFKPDDGQETVFAQTKPIVTSVLDGYNVCIFAYGQTGTGKTFTMEGTPENRGVNYRTLEELFRCSESKSHLMKFELSVSMLEVYNEKIRDLLVDNSNQPPKKLEVKQSAEGTQEVPGLVEAQVYNTDGVWDLLKKGYAVRSVGSTAANEQSSRSHCLLRVTVKGENLINGQRTRSHLWLVDLAGSERVGKVEVEGERLKESQFINKSLSALGDVISALASKTSHIPYRNSKLTHMLQNSLGGDCKTLMFVQISPSSADLGETLCSLNFASRVRGIESGPARKQADVSELLKSKQMAEKLKHEEKETKKLQDNVQSLQLRLTAREHICRGLQDKVRDLEFQLAEERKTRIKQESRALATASSTTTTTSRHLRETLPTIIEKKPPLAPTRMRMPLRRITNFMPQQQPSQGHSKRFSDTTFKENNNSNRRSSSMDVNTLMKPRRSSIAFRPAPAPSAIASSNKTIMPRRRVSIATLRPEPSSLSSMETPSRPPPSFRGDPRKARYSKLFSPDRNLVTPNAMKSSRFMKSPLGGGGSSWKPSHPTVIALQKKAVVWSPLKFKNRRPSLVAIRSSASSSSASDLLRREQ
What are the official names of this protein?
Kinesin-like protein KIN-14S.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.
Protein: GSA_CROS8
Sequence: MSKSENLFAAARELIPGGVNSPVRAFTGVGGTPLFIERADGAYLYDADGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAERGLSFGAPTEMEVKMAQLVTELVPTMDMVRMVNSGTEATMSAIRLARGFTRRDKIIKFEGCYHGHADHLLVKAGSGALTLGQPNSPGVPADFAKHTLTCTYNDLASVREAFELYPQDIACIIVEPVAGNMNCIPPQPDFLPGLRALCDEFGALLIIDEVMTGFRVALAGAQAYYNVVPDLTCLGKIIGGGMPVGAFGGRREVMEALAPTGPVYQAGTLSGNPIAMAAGFACLSEVAQPGVHSTLDALTTQLAEGLLDAAQEAGVPLVVNHVGGMFGFFFTDADSVTCYHDVVKCDVERFKRFFHLMLEEGVYFAPSAFEAGFMSVAHSEEDINNTIDAARRVFAKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_XANCP
Sequence: MSTIRCDIVSAEQEIFRGEATLVVATGELGELGIAPKHAPLITRLKPGKVVVTTASGEQLDFAISGGILEVQPQVVTVLVDTAIRAQDIDEAAVRKAKEEAERLLANRGDTVDVEQAQRQLAEATVQLQALERLRRTLKH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MENH_YERE8
Sequence: MTLACCKLDPHPQSPARQHTGPWLVWLHGLLGSGQDWLPVAELCGDYPSLLIDLPGHGNSVALTTTGFEDISRQISETLQANGIREYWLAGYSLGGRIAMYHACYGHKVGLQGLLVEGGNLGLESDELRKARFEQDCQWAQRFRHEPLPQVLADWYQQDVFADLDSQQREQLVAVRANNHGPAVADMLEATSLGHQPWLLPALQCLSVPYTYLCGERDHKFQQVAHQYKLPLRTLARAGHNAHRANPGAFAALVLSFLSQSSFLPLSSFLPPSR
What is the function of this protein?
Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
What are the official names of this protein?
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, SHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MenH family.
Protein: SPEA_SHESW
Sequence: MNDWSIDDARAGYNVTHWSQGFYGISDQGEVTVSPDPKNPEYKIGLNELAKDMVKAGVALPVLVRFPQILHHRVNSLCQAFDQAIQKYEYQADYLLVYPIKVNQQQTVVEEILASQASKEVPQLGLEAGSKPELMAVLAMAQKASSVIVCNGYKDNEYIRLALIGEKLGHKVYIVLEKLSELKMVLAESKRLGVTPRLGLRARLAFQGKGKWQASGGEKSKFGLSAAQILTVVDQLKQNDMLDSLQLLHFHLGSQIANIRDIRQGVSEAGRFYCELRELGASVNCFDVGGGLAVDYDGTRSQSNNSMNYGLTEYANNIVNVLTDICNEYAQPMPRIISESGRYLTAHHAVLITDVIGTEAYQPENIQPPAEESPQLLHNMWHSWSEISGRADQRALIEIYHDSQSDLQEAQSLFALGQLSLAERAWAEQANLRVCHEVQGLLSTKNRYHRPIIDELNEKLADKFFVNFSLFQSLPDAWGIDQVFPVLPLSGLDKAPERRAVMLDITCDSDGIVDQYVDGQGIETTLPVPAWSAESPYLIGFFLVGAYQEILGDMHNLFGDTNSAVVRIEENGVTNIESVLAGDTVADVLRYVNLDAVAFMRTYEELVNLHIEEDERAQILEELQVGLKGYTYLEDFS
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: TRI23_CAEEL
Sequence: MNEYGCNVCNEEYSARDPLKCPRVLTGCGHTICHNCAISIAGRNSSIFCPFDRTATQIPGGDLQNLKKNFALLELLEKIADGGGLLEKSGEVVKFDRYSKERLLNLECDEDSEHVAVIYCTVCDSNLCERCSESTHSTNVLSKHRRIPLTEKPPPLVHCRLHSSYVVEFVCKELSCDTESPLMCMMCRDYGRHKGHSHVLIEKEVEDLREKVREHLGELSKQSETIGNALHSIDSVIHELTPGQEDGSLEETRQEVRNHFRRLRTALDRDEEDAVETVDRYARNRVESLQTQKERLEAISSKIGNTCTTLQKALIMERGKILDRKDDLLALAESTAAEPTAVLDQSQLSTRIAFSFLNDRKLHIGDFIESRVVLLGLDGAGKTSIVRRLKKVQMDTVMAPHPTIGFNIETIHYKNYRLNFWDVGGLPKLRHLWKHYYSNAQAIFYVIDGYAVERFSEAIKELNRVMSDPLVGTCPVIVAVNRKDGYALNGHMDALLSQLEALPFQHHFHCCDAATGSGIDQIIDQITVCLSRLNGTCPV
What is the function of this protein?
Acts as an E3 ubiquitin-protein ligase.
What are the official names of this protein?
E3 ubiquitin-protein ligase arc-1, Putative GTP-binding protein trim-23 homolog, RING-type E3 ubiquitin transferase arc-1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the small GTPase superfamily. Arf family.
Protein: GSA_FRATF
Sequence: MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYIGSWGPMILGHCDDDVLEAIQCQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGTEATISAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSGALSLGQPNSPGVPEDVVKDTLVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDGFLAKLRAICDQNSSLLIFDEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAGTLSGNPIAMTAGIKTLEKISQPGFFDELGAKAQKLVDGLNEAAKAYDFNFHAKCLGGMFGLFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAPSAYEAGFISIAHSDEDIEKTICLAKKFFQEN
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC5_MOUSE
Sequence: MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLSAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRKPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRRSLSTSSADFSQRDDTNDGSGGARAKSKSVSFNVGCKKKACHGAPLIRTVPRASGAQGKPKSESSSKRSFMGPSFKKLGLFFSKFNGQTSEPTSEPMYTISDGIAQQHCMWQDIRYSQMEKGKAEACSQSQMNLGEVELGEIRGAAARSSECPLACSSSLHCASGICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL
What is the function of this protein?
Thought to form a receptor-activated non-selective calcium permeant cation channel.  Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.  Has also been shown to be calcium-selective.  May also be activated by intracellular calcium store depletion (By similarity).  Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (PubMed:32110987).
What are the official names of this protein?
Short transient receptor potential channel 5, TrpC5, Capacitative calcium entry channel 2, CCE2, Transient receptor protein 5, TRP-5, mTRP5, Trp-related protein 5.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COAD_METNO
Sequence: MNRTALYAGSFDPVTNGHVDVIRQACRLVGRLVIAIGVHPGKTPLFSAEERAELIRATCDPIAAAEGSALEVVTFDDLAVSAARRAGASLFIRGLRDGTDLDYEMQLAGMNSAMAPEVQTVFLPASTGVRPITATLVRQIAAMGGDVRPFVPELVAERLEARFAKP
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_PSYCK
Sequence: MARNDKNDKNEQTDGLVERLVTVDRVAKVVKGGRIFSFTALTVVGDGNGRVGFGRGKAREVPAAIQKALEAAKRNMITVELNDATLYHPIKARHGASKVYMQPASEGTGVIAGGAMRAVLEVAGVKDVLTKCYGSTNTANVVRATFNGLRDMSTPEKMAAKRGKSVDEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: FADA_ENT38
Sequence: MEKVVIVDAIRTPMGRSKGGAFRHVRAEDLSAHLMRSLLARNPALEASAIDDIYWGCVQQTLEQGFNIARNASLLAEIPHSVPAVTVNRLCGSSMQALHDAARMIMTGDAQVCMVGGVEHMGHVPMSHGVDFHPGMSRNVAKAAGMMGLTAEMLSRMHGISREMQDQFAARSHARAWAATQSGAFKNEILPTGGHDVDGVLKQYYYDEVIRPETTVEALSALRPAFDPVTGTVTAGTSSALSDGAAAMLVMSESRARELGLTPRARIRSMAVVGCDPSIMGYGPVPASKLALKKAGLTASEIDVFEMNEAFAAQILPCIKDLGLMEQIDEKINLNGGAIALGHPLGCSGARISTTLINLMERKDAQFGLATMCIGLGQGIATVFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSLBB_XENLA
Sequence: MRLIQNMCTITEYPPATNTDCGSSSSAGTASSRVIKIAVVGGSGVGKTALVVRFLTKRFIGDYERNAGNLYSRQVQIDGTNLAIQVQDTPGVQINEQNLESNEQLNKSLRWADAVVIVFSITDCKSFDLISHLHRHARQLHPDNRIPIVIVANKADLLHLKQVEPQHGLQLANMLGCTFYEVSVSENYNDVYNAFQVLCKEISKQQNTGTSERRKNSIIPRPKSPNMQDLKRRFKQALSSKVRTATSV
What are the official names of this protein?
Ras-like protein family member 11B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
Protein: RS10_BORHD
Sequence: MITKDKIRVRLFSFDVKILDQSAESIVRAVQKSKAQIKGPIPLPTKIKKYTVLRSPHVNKKSREQFEMRTHKRLIDILEPTSALMDSLMKLELPAGVEVDIKQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PRX2F_ARATH
Sequence: MAMSILKLRNLSALRSAANSARIGVSSRGFSKLAEGTDITSAAPGVSLQKARSWDEGVSSKFSTTPLSDIFKGKKVVIFGLPGAYTGVCSQQHVPSYKSHIDKFKAKGIDSVICVSVNDPFAINGWAEKLGAKDAIEFYGDFDGKFHKSLGLDKDLSAALLGPRSERWSAYVEDGKVKAVNVEEAPSDFKVTGAEVILGQI
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.  Reduces preferentially hydrogen peroxide rather than alkyl peroxides.  May be involved in mitochondrial redox homeostasis.
What are the official names of this protein?
Peroxiredoxin-2F, mitochondrial, Glutaredoxin-dependent peroxiredoxin, Peroxiredoxin IIF, Thioredoxin peroxidase 2F.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx5 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GHRA_ECOSE
Sequence: MDIIFYHPTFDTQWWIEALRKAIPQARVRAWKSGDNDSADYALVWHPPVEMLAGRDLKAVFALGAGVDSILSKLQAHPEMLNPSVPLFRLEDTGMGEQMQEYAVSQVLHWFRRFDDYRIQQNSSHWQPLPEYHREDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVLINLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFNREPLPPESPLWQHPRVTITPHVAAITRPAEAVEYISRTIAQLEKGERVCGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOB_ECOLC
Sequence: MKRAFIMVLDSFGIGATEDAERFGDVGADTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLAKAHEGSTGFIPAGMDGNAEVIGAYAWAHEMSSGKDTPSGHWEIAGVPVLFEWGYFSDHENSFPQELLDKLVERANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTNGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKHGQVVSVGKIADIYANCGITKKVKATGLDALFDATIKEMKEAGDNTIVFTNFVDFDSSWGHRRDVAGYAAGLELFDRRLPELMSLLRDDDILILTADHGCDPTWTGTDHTREHIPVLVYGPKVKPGSLGHRETFADIGQTLAKYFGTSDMEYGKAMF
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHAC_HALHT
Sequence: MSSNPFNPFEAALNWQRKTLENMTDAAETSQIADERLELMESVEVGQTPSDVVYEENKLELLHYDAEATGIEVAEEDKEAVPILIVYALINRPYILDLQEERSVVRRLLEAGHDVYLIDWNEPSRLDQHLTLDDYVNRYMDNCVDVVRERSGQDAINILGYCMGGTMSVMYTALHKEKVNTLGLMAAGLCFDHTGGVLEEWGSEEYYSPQDVVDTFGNVPSDMLDIGFALMDPVENYVTKYIRFAENMENEGFVENFGRMEQWLGDGIDVAGEAYVQFLEDVYQDNKLYKNELELNGKHVDLDNIDMPVLQLMGEYDHLIPPEASKPFNDVIASDDTRTIEFSTGHIGLSVSSSTHADLWPEVAEWYSERSTGGEEVDIEVESPEDDTVDQSESTDIEVDATDDVDADATEDDADAADEPADVDSVSGIGPTYAERLHAAGIHSVADLAEYDAAELADIAETTESRAQDWLDQL
What is the function of this protein?
Involved in the production of polyhydroxyalkonic acids (PHAs), which are water-insoluble biopolymers used as intracellular energy reserve material when cells grow under conditions of nutrient limitation.  PHAs are composed primarily of 3-hydroxybutyric acid (3HB) and 3-hydroxyvaleric acid (3HV).  Required for the production of poly-beta-hydroxybutyrate (PHB) and poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV).
What are the official names of this protein?
Poly(3-hydroxyalkanoate) polymerase subunit PhaC, PHA polymerase, PHB synthase subunit PhaC, Poly(3-hydroxybutyrate) polymerase subunit PhaC, PHB polymerase, Polyhydroxyalkanoic acid synthase subunit PhaC, PHA synthase.
What is the protein family that this protein belongs to?
Belongs to the PHA/PHB synthase family.
Protein: TCO89_YEAST
Sequence: MVHRGRTLKSDTDVTSLNASTVSHQSKPFRQFSTRSRAKSNASFKGLRRVLTHDGTLDNDYFNKHNVSQKCKSSDALFRKRTISGLNMTALTRVKSNQGKRSASFHSPVHNTLLSPKNSSHSNTGTAGFGLKPRRSKSTQSVLSLRDAQESKKSESTTDEEVECFSEDNIEDGKVNNDKVIAEHVMPEEKKNVQQLNQNELQSPDSIDEQEEDKSGTDGKENHRAVSLPLPHLSSNNYFGESSHSIEHQKDGETSPSSIETKLNATSVINEEGQSKVTKEADIDDLSSHSQNLRASLVKAGDNISEAPYDKEKKILDVGNTLAAHKSNQKPSHSDEQFDQEDHIDAPRSNSSRKSDSSFMSLRRQSSKQHKLLNEEEDLIKPDDISSAGTKDIEGHSLLENYAPNMILSQSTGVERRFENSSSIQNSLGNEIHDSGEHMASGDTFNELDDGKLRKSKKNGGRSQLGQNIPNSQSTFPTIANIGSKDNNVPQHNFSTSISSLTNNLRRAAPESFHGSRMNNIFHKKGNQNLLLRSNDLNKNSAAPASPLSNEHITSSTNSGSDANRQSNSGAKFNSFAQFLKSDGIDAESRTQRKLWLQRENSIMDLSSQNDGSDSIFMAGNIDAKREFERISHEYSNVKRFYNPLDEALLRVQPIITGNANNIRKKSHNDAQSIAHSSSDTDHKDEDDLLFTNYDKKFDDLYPHLASAKIQAVLSGIWKSESYLFNKDVNPINKNRTTSTNHSVGHTASQNARNLLRGPMGSSTTLHHQRVINSLQPTTRAVNRRMENVGYMHTQPQQR
What is the function of this protein?
Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals.  Nutrient limitation and environmental stress signals cause inactivation of TORC1.  Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing.  TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery.  TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm.  TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions.
What are the official names of this protein?
Target of rapamycin complex 1 subunit TCO89, TORC1 subunit TCO89, 89 kDa TOR complex 1 protein.
What is the protein family that this protein belongs to?
Belongs to the TORC subunit TCO89 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also localizes to membranous structures both proximal to, yet distinct from, the plasma membrane as well as within the cell interior, probably endosomal or Golgi membranes.
Protein: HIS5_MYCPA
Sequence: MTSKSVVVLDYGSGNLRSAQRALERVGASVQVTADADAAAAADGLVVPGVGAYEACMTGLRKIGGDRIIAERVAAGRPVLGVCVGMQILFARGVEFSVETSGCGQWPGSVTRLQAPVIPHMGWNVVESGPDSVLFRGLDADTRFYFVHSYAAQQWEGSPEAVLTWSRHEGPFLAAVEDGPLSATQFHPEKSGDAGAAVLRNWIERL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_GEOMG
Sequence: MIQMQTILDVADNSGARKLFCIKVLGGSKRKYAGIGDIIVASVREAIPNSKVKKGDVVKAVIVRTAKEVGRLDGSYIRFDDNSAVVINNQREPVGTRIFGPVARELRARKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.