PharMolix/UniProtQA huggingface dataset:
Protein: CH60_CLOBB
Sequence: MAKMLKFGEDARRSMQVGVDKLADTVKVTLGPKGRNVVLDKKFGSPLITNDGVSIAREIELEDPYENMGAQLVKEVATKTNDVAGDGTTTATLLAQAIIREGLKNVTAGANPMLIRNGIRMAVDKAVEEIKKISKPVEGKEDIARVAAISAADEEIGKLIADAMEKVGNEGVITIEESKSMGTELDVVEGMQFDRGYVSPYMSTDTEKMEAILDTPYILITDKKITNIQEILPILEQIVQAGRKLLIIAEDIEGEAMATLVVNKLRGTFTCVAVKAPGFGDRRKEMLEDIAILTGGTVIAEELGRDLKEVTLDMLGQAESVKVSKDNTVVVNGKGNPENIKDRISQIKAQIEETSSEFDKEKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALAATKAAVEEGIVPGGGTAYINVIKEVEKLTSDVQDTELGIKIIVKSLEEPLRQIASNAGVEGSVIIEKVKNSEVGTGYDALYGKYVNMIKSGIVDPTKVTRSALQNAASVSATFLTTEAAVAEIPQKEPAMPAPGMGMDGMY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAMKD_DICDI
Sequence: MEKSIESISSSTLNILDNKNYKKWDNETVCKWLLNNIKTIQKVSIEIFQANEIIGKDLEFLTDKILLKMGVGIRDILNFKFEYQILKNCYNNNNNNNHITINNFNYNFNNFKININKDLLKVVVNAPIININEYQYIETISKNKFCEIEKYKKSQTKVNEYIIIKKIIKNSTLNEEKLINEIDTIYLLDHPNLIKIIGYCKDKNYFYIGMKYYETFKFKQSNISKFGKNFEQVIRKISFKILSAIDYLHSLEPPIIHGNINAKNILLDNENNEPILIDFGLSYKSIDLLTNQKTQFISPCFITPEYFYKKTKNKISKEADIFSFGSTISNMIKGGTDFKEDEEGFEELKRTFAGVLTSRDKVSFDYRSLFTEINKDEPCFRPSSKELLKSFWFVEPPQPSFKTSEITTNLLIYYLKKYGCYIIRDGVAMVSLNFNENIYSTSSIIGSEFSHQPKINEKHKYFKEINQFYSKILSESFQAKIGWYLLNLNNEFKDKPYFKNIFLSFSTSDKLEINSVADLNLKLTIFFYNSITMSLIYQTIYQKPKSFKIVDYL
What are the official names of this protein?
Probable inactive serine/threonine-protein kinase samkD, SAM domain-containing protein kinase D.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: SSRP_FRACC
Sequence: MPRETGRRLIAQNKRARHDYDILDTYEAGLVLRGTEVKALRAGRASLVDGFAQISDGEIWLHNVHIPEYTEGTWTNHAPRRKRKMLLHRAEIEKLVGKTQEGGLTLVPLSLYWKDGRAKIEIALARGRKSYDKRHAIAERDAAREIGRAMGRRAKGRYL
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: CLDS9_SALSC
Sequence: MTSVNLSRAPAAIIRRRLQLQPEFHAECSWLKSSSKHAPFTLSCQIRPKQLSQIAELRVTSLDASQASEKDISLVQTPHKVEVNEKIEESIEYVQNLLMTSGDGRISVSPYDTAVIALIKDLKGRDAPQFPSCLEWIAHHQLADGSWGDEFFCIYDRILNTLACVVALKSWNLQSDIIEKGVTYIKENVHKLKGANVEHRTAGFELVVPTFMQMATDLGIQGLPYDHPLIKEIADTKQQRLKEIPKDLVYQMPTNLLYSLEGLGDLEWERLLKLQSGNGSFLTSPSSTAAVLMHTKDEKCLKYIENALKNCDGGAPHTYPVDIFSRLWAIDRLQRLGISRFFQHEIKYFLDHIESVWEETGVFSGRYTKFSDIDDTSMGVRLLKMHGYDVDPNVLKHFKQQDGKFSCYIGQSVESASPMYNLYRAAQLRFPGEEVLEEATKFAFNFLQEMLVKDRLQERWVISDHLFDEIKLGLKMPWYATLPRVEAAYYLDHYAGSGDVWIGKSFYRMPEISNDTYKELAILDFNRCQTQHQLEWIQMQEWYDRCSLSEFGISKRELLRSYFLAAATIFEPERTQERLLWAKTRILSKMITSFVNISGTTLSLDYNFNGLDEIISANEDQGLAGTLLATFHQLLDGFDIYTLHQLKHVWSQWFMKVQQGEGSGGEDAVLLANTLNICAGLNEDVLSNNEYTALSTLTNKICNRLAQIQDNKILQVVDGSIKDKELEQDMQALVKLVLQENGGAVDRNIRHTFLSVSKTFYYDAYHDDETTDLHIFKVLFRPVV
What is the function of this protein?
Involved in the biosynthesis of labdane-type diterpenoid including sclareol, a diterpene-diol that is used as fragrance and flavoring, and has anticancer effects (able to kill leukemic and colon cancer cells by apoptosis) (Probable).  Sclareol can also be used as synthesis precursor of ambergris substitution fragance products such as ambrox (Probable).  Terpene synthase that produces 8-hydroxycopalyl diphosphate from geranylgeranyl diphosphate (GGPP) (PubMed:23113661, PubMed:22834731).
What are the official names of this protein?
Copal-8-ol diphosphate hydratase TPSSA9, chloroplastic, 13-labden-8,15-diol pyrophosphate synthase TPSSA9, SsLPS, Diterpene synthase Sa9, SsTpsSa9, Labd-13-en-8-ol diphosphate synthase, SsLPPS.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EFTU_HELP2
Sequence: MAKEKFNRTKPHVNIGTIGHVDHGKTTLSAAISAVLSLKGLAEMKDYDNIDNAPEEKERGITIATSHIEYETENRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPHIVVFLNKQDMVDDQELLELVEMEVRELLSAYEFPGDDTPIIAGSALRALKKAKAGNVGEWGEKVLKLMAEVDAYIPTPKRDTEKTFLMPVEDVFSIAGRGTVVTGRIERGVVKVGDEVEIVGIRATQKTTVTGVEMFRKELEKGEAGDNVGVLLRGTKKEEVERGMVLCKPGSITPHKKFEGEIYVLSKEEGGRHTPFFTNYRPQFYVRTTDVTGSITLPEGVEMVMPGDNVKITVELISPVALELGTKFAIREGGRTVGAGVVSNIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_XYLFM
Sequence: MPLLRIATRKSLLAMRQSEYVAARLRMLCPDLDVVLVPMSTRGDEILDRSLAAIGGKGLFLKELELAMLRGDADCAVHSLKDVPMDLEPPFMLAAVLSRDDPADALISNVYLSLESLPIGARVATSSLRRQAQLRFYRPDLRLFDLRGNVNTRLAKLDNGDYDAIVLACAGLRRLGLEQRMTARLAPPEWLPAPGQGAIAVESLTEDARIGTLLAGLDDLPTRQCVVAERTMNRALHGSCHVPVGAYASYGVGGMRLQGLVGCVADGRLVRAELCSAKDEGDMLGRAVAQCLLDAGAAELLAATA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: EF1A_SOYBN
Sequence: MGKEKVHISIVVIGHVDSGKSTTTGHLIYKLGGIDKRVIERFEKEAAEMNKRSFKYAWVLDKLKAERERGITIDIALWKFETTKYYCTVIDAPGHRDFIKNMITGTSQADCAVLIIDSTTGGFEAGISKDGQTREHALLSFTLGVKQMICCCNKMDATTPKYSKARYDEIVKEVSSYLKKVGYNPDKIPFVPISGFEGDNMIERSTNLDWYKGPTLLDALDQISEPKRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPTGLTTEVKSVEMHHESLTEAHPGDNVGFNVKNVAVKDLKRGYVASNSKDDPAKEAANFTAQVIIINHPGQIGNGYAPVLDCHTSHIAVKFAELMTKIDRRSGKELEKEPKFLKNGDAGFVKMIPTKPMVVETFSEYPPLGRFAVRDMRQTVAVGVIKNVEKKDPTGAKVTKAAQKKK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHZI_PSEFL
Sequence: MHMEEHALSAMDDELKLMLGRFRHEQFVEKLGWRLPIPPHQAGYEWDQYDTEHARYLLAFNEHRSIVGCARLIPTTFPNLLEGVFSHACAGAPPRHPAIWEMTRFTTREPQLAMPLFWKTLKTASLAGADAIVGIVNSTMERYYKINGVKYERLGSVIDHQNEKILAIKLSAHREHHRGARLPSGFTSEALLEETA
What is the function of this protein?
Required for the synthesis of a yet unknown N-aceyl-homoserine lactone (N-aceyl-HSL), an autoinducer molecule which binds to PhzR and thus regulates phenazine production.
What are the official names of this protein?
Acyl-homoserine-lactone synthase, Autoinducer synthesis protein PhzI.
What is the protein family that this protein belongs to?
Belongs to the autoinducer synthase family.
Protein: AH2_PRUSE
Sequence: AKTDPPIHFASLXRS
What are the official names of this protein?
Amygdalin beta-glucosidase I', Amygdalin hydrolase isozyme I', AH I'.
Protein: MRAY_SHEPW
Sequence: MLVYLAEYLTQFYSGFNVFSYVTFRAILGLMTALMFSLWWGPKMIERLQLLQIGQVVRNDGPESHFSKRGTPTMGGLLILAGIFISVLLWGDLGSRYVWVVLFVLASFGTIGFIDDYRKVVRKDTKGLIARWKYLLQSIAAIVIAVYLYASADTAGETQLVVPFFKDVMPQLGAFFIVLVYFTIVGSSNAVNLTDGLDGLAIMPTVMVAAAFALIAYLSGHVQFANYLHIPYLPGAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGAALGAIAVLVRQEILLVIMGGVFVMETVSVILQVGSYKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLFLVLLGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PURA_PSEA6
Sequence: MAKNVVVLGTQWGDEGKGKVVDLLTDKATYVVRYQGGHNAGHTLVIDGEKTVLHLIPSGILRENVTCVIGNGVVLSPEALLKESAMLEERGVPVKERLRISEACPLILPFHVELDLAREKARGDKPIGTTGRGIGPAYEDKVSRRGLRVGDLFNPTDFAVKLKEVLEYHNFMLTNYYKVEPVSYEKTLADALAVADILKAMVVDVTDVLDRARKRGDEIMFEGAQGTLLDIDHGTYPYVTSSNTTVGGVATGAGFGPLHLDYVLGIVKAYTTRVGSGPFPTELGCDVGQHLGIKGHEFGATTGRKRRTGWFDAVAMKRAVQINSITGFCLTKLDVLDGLETLSICTGYKHADGTVKDVPPMAADDYELITPVYEEMPGWSENSFGVTEYDNLPQAAKNYIKRLEELTGVPIDIISTGPDRNETIVLRHPFEV
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXJ_PELPB
Sequence: MRLAVNIDHIATLRNARGEQEPDPVAAALLAEKCGAAGIVCHLREDRRHINDHDLARLREAVTTKLDLEMAMTPELQQIALKTRPELITLVPEKREELTTEGGFDIVRHYAVLAAYLKPFNAAGIEVSLFIEPEKKAIDLAKQAGADLVELHTGLYALKKEGEAQSKELQRIREAAIHARSLGLKVVAGHGLNYLNIAPFREIEEIEEVSIGHAIIARAVLTGLEEAIREMLRIIK
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DODEC_HALHL
Sequence: MSDHVYKIVELTGSSPNGIEEAVNNAIARAGETLRHLRWFEVVDTRGHIEGGRVNHWQVTVKVGFTLEGG
What is the function of this protein?
May function as a riboflavin storage protein that binds and sequesters riboflavin, thereby protecting cells against undesirable reactions mediated by free riboflavin.  Protects bound flavin against light damage; flavin fluorescence is rapidly quenched by interaction with Trp-39.
What are the official names of this protein?
Dodecin.
What is the protein family that this protein belongs to?
Belongs to the dodecin family.
Protein: Y109_CHLMU
Sequence: MQLTSQAFSYGRPIPKKYSCQGVGISPPLSFSDIPSEAKSLALIVEDPDVPANVREDGLWIHWIVYNLSPIVSNLAEGAQIFAVQGINTAGEIGYCPPCPPDAKHRYYFYAYALDVVLPEEEGVTKEQLLEAMEGHILATAELMGTYEQD
What are the official names of this protein?
UPF0098 protein TC_0109.
What is the protein family that this protein belongs to?
Belongs to the UPF0098 family.
Protein: CDC7_MOUSE
Sequence: MEEPMAFSSLRGSDRCPADDSLKKYEQSVKLSGIKRDIEELCEAVPQLVNVFKIKDKIGEGTFSSVYLATAQLQEGHEEKIALKHLIPTSHPMRIAAELQCLTVAGGQDNVMGLKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTRDTKIELLKFVQSEAQQEDCSRNKYHGVVGHKGLLSRPAPKTVDQQCTPKTSVKRSYTQVHIKQGKDGKERSVGLSVQRSVFGERNFNIHSSISHESPAEKLIKQSKTVDIISRKLATKKTAISTKAMNSVMRETARSCPAVLTCDCYGSDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSVLCSKEVPAQDLRALCERLRGLDSTTPRSASGPPGNASYDPAASKNTDHKASRVQAAQAQHSEDSLYKRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFFKDMCS
What is the function of this protein?
Kinase involved in initiation of DNA replication.  Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN.
What are the official names of this protein?
Cell division cycle 7-related protein kinase, CDC7-related kinase, muCdc7.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTH_RENSM
Sequence: MSNTWLVVGLGNPGPDYSHTRHNIGFMVAEELASRIGASFKSNKSRALVAEGRLGMGGPKLVLAKPQTFMNLSGGPTSALAKFYDLGADNVIAVQDEIDIPFNTIKLKIGGGEGGHNGLRDISKALGAKEYLRVRVGVGRPPGGQGDAAGHVLKVFSTAEKKELPFLIQDAADAVELLISDGLLAAQQKFHPAK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DACA_LISMO
Sequence: MDFSNMSILHYLANIVDILVVWFVIYKVIMLIRGTKAVQLLKGIFIIIAVKLLSGFFGLQTVEWITDQMLTWGFLAIIIIFQPELRRALETLGRGNIFTRYGSRIEREQHHLIESIEKSTQYMAKRRIGALISVARDTGMDDYIETGIPLNAKISSQLLINIFIPNTPLHDGAVIIKGNEIASAASYLPLSDSPFLSKELGTRHRAALGISEVTDSITIVVSEETGGISLTKGGELFRDVSEEELHKILLKELVTVTAKKPSIFSKWKGGKSE
What is the function of this protein?
Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (PubMed:25605729).  c-di-AMP is a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes (PubMed:20508090).  Expression of truncated proteins (missing first 80 or 100 residues) in E. coli leads to c-di-AMP synthesis (PubMed:25605729).
What are the official names of this protein?
Diadenylate cyclase, DAC, Cyclic-di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase CdaA.
What is the protein family that this protein belongs to?
Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LTOR2_DANRE
Sequence: MLRPKALTQVLSQANTSGVQSTLLLNNEGSLLTYSGYGDTDARVTAAIASNIWAAYDKNGHQAFNEDKLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAEALVQYLEEPLTQVAAS
What is the function of this protein?
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids.  As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.  Adapter protein that may regulate the MAP kinase cascade (By similarity).
What are the official names of this protein?
Ragulator complex protein LAMTOR2, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2.
What is the protein family that this protein belongs to?
Belongs to the GAMAD family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ILVC_ECOSM
Sequence: MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSDVVRTVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNAQLRDVNEAIRSHAIEQVGKKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ARCA_STAA9
Sequence: MTDGPIKVNSEIGALKTVLLKRPGKELENLVPDYLDGLLFDDIPYLEVAQKEHDHFAQVLREEGVEVLYLEKLAAESIENPQVRSEFIDDVLAESKKTILGHEEEIKTLFATLSNQELVDKIMSGVRKEEINPKCTHLVEYMDDKYPFYLDPMPNLYFTRDPQASIGHGITINRMFWRARRRESIFIQYIVKHHPRFKDANIPIWLDRDCPFNIEGGDELVLSKDVLAIGVSERTSAQAIEKLARRIFENPQATFKKVVAIEIPTSRTFMHLDTVFTMIDYDKFTMHSAILKAEGNMNIFIIEYDDVNKDIAIKQSSHLKDTLEDVLGIDDIQFIPTGNGDVIDGAREQWNDGSNTLCIRPGVVVTYDRNYVSNDLLRQKGIKVIEISGSELVRGRGGPRCMSQPLFREDI
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUTA_ECO5E
Sequence: MLDEKSSNTASVVVLCTAPDEATAQDLAAKVLAEKLAACATLIPGATSLYYWEGKLEQEYEVQMILKTTVSHQQALLECLKSHHPYQTPELLVLPVTHGDTDYLSWLNASLR
What is the function of this protein?
Involved in resistance toward heavy metals.
What are the official names of this protein?
Divalent-cation tolerance protein CutA.
What is the protein family that this protein belongs to?
Belongs to the CutA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF6_ENTDS
Sequence: MALRAEYENSADIGVFTKLTNKYCITAPGGSSSYKIIEQEVSPKIPCVEATIGGLRIIGRLAVGNRKGLLLPNTCNDQELLHLRNSLPDDVVVQRVEERMSALGNCIACNDYVALVHPEIDRETEEIIADVLGVEVFRHAVGGNPLVGTYSVITNKGAMLAPNTTQQEQEEIGTILQVPLVAGTVNRGSNLLGSGMIVNDWCGFVGMDTTATELSIVEGIYKLRNETDVQFASVMELMK
What is the function of this protein?
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm.  May also be involved in ribosome biogenesis.
What are the official names of this protein?
Eukaryotic translation initiation factor 6, eIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Protein: DLTC_STRA1
Sequence: MDIKSEVLAIIDDLFMEDVSSMMDEDLFDAGVLDSMGTVELIVELESHFNIDIPIAEFGRNDWNTANKIVAGVTELCNA
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_PARXL
Sequence: MRNQQLPIVPLLRDELPLDTVELARFMIGKYLVRDLPEGRMSGRIVETEAYPVGDSTSHAFIGRRPYNGSLFLARGHAYVRLTYGLSYMLNMSAEAEDVGAGILFRAIEPLEGLPLMEARRPGVPLRDLARGPGRLTTALGIGQAFDGLDLCAGRDLWIGVLERGETLVGVTTRIGLSREMHRPLRFFEPGSAFVSGPRKLLLTPQPGARTRA
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: PLAT5_MOUSE
Sequence: MGLSPAASGEFGIRLSRVPWPRPTQISKTSSTESSDTQSATGQSTVPHSDSASSQALLVQFLPKQLKQDRRLEQARSFQQGEKPETSLELTPSKKRTELIPTSNSEIESTQKNQAVEGNPRPRPGDLIEIFRIGYEHWAIYVEDDCVVHLAPPSEFEAGSITSIFSNRAVVKYSRLEDVLHGCSWKINNKLDGTYLPLPVDKIMQRTKNMINKIVQYSLIEGNCEHFVNDLRYGVPRSQQVEHALVEGAKAAGAVLSAVVDSIRPKPITA
What is the function of this protein?
Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity).  Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity).  Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777).
What are the official names of this protein?
Phospholipase A and acyltransferase 5, Ca(2+)-independent N-acyltransferase, iNAT, H-rev107-like protein 5, HRAS-like suppressor 5, HRSL5.
What is the protein family that this protein belongs to?
Belongs to the H-rev107 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: Y053_HAEIN
Sequence: MKERIKAICLEKPNNVVVKEVPYPEKSDNDVLIQVESMGICGSDIGAYRGTNPLVTYPRILGHEIVGRVIESGIGMSDGVRVGDRVIVDPYVCCGQCYPCSIGRTNCCESLKVIGVHIDGGMQEVIRHPAHLLTKVPDNLPIHQLPLAEPLTIALHALHRTTLKSGEHIVIIGAGAIGLMAALAAVQYGAIPILVDILEQRLEYAKSLGIEHIVNPHKEDDIKRIKEITSGRMAEVVMEASGANISIKNTLHYASFAGRIALTGWPKTETPLPTNLITFKELNIYGSRTSKGEFEEALDMLATNKINASHIITKCIKFEEIPSFISDLSDHPENYLKINAVF
What are the official names of this protein?
Uncharacterized zinc-type alcohol dehydrogenase-like protein HI_0053.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: MURG_VESOH
Sequence: MFNTAKKILIMAGGTGGHIFPALAIANELKKHSSNIQWLGSNLGMENNIIPKHNIKLHTVSSVGLRGKNVISLIKAPFLLSYATLQVIKIFLKFKPDVVLGMGGFTSGIGGLVAWVFKTTLVIHEQNSIPGTTNKILNKIATKTFQAFDDTFIRNATTSGNPIVFNPIEKQNNNKLNLLIIGGSLGSKPINEIVTQLNIDINIWHQTGKLHADTVKSQYKNSAVKVTAFITEMASAYAWADIVLCRAGAMTVSELMLSATSSILIPLPNSIDNHQFHNAKILSDNNAGILIEQKDLTIELLEGILLNINKNQIKQMSSNALKIAKPNAVKQIVDYLLVSD
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.