PharMolix/UniProtQA huggingface dataset:
Protein: KCC1D_HUMAN
Sequence: MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERRPRPTTVTAVHSGSK
What is the function of this protein?
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons.  In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst.  Activates the transcription factor CREB1 in hippocampal neuron nuclei.  May play a role in apoptosis of erythroleukemia cells.  In vitro, phosphorylates transcription factor CREM isoform Beta.
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type 1D, CaM kinase I delta, CaM kinase ID, CaM-KI delta, CaMKI delta, CaMKID, CaMKI-like protein kinase, CKLiK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.
Protein: YNZC_BACSU
Sequence: MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSSMKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH
What are the official names of this protein?
UPF0291 protein YnzC.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_YERP3
Sequence: MSLDIAKYPTLALAENPEELRMLPKESLPKLCDELRQYLLTCVSRSSGHFASGLGVVELTVALHYVYNTPFDHLIWDVGHQAYPHKILTGRRDRISTIRQKDGLHPFPWRGESEYDVLSVGHSSTSISAGLGMAVAAEREGKGRRTVCVIGDGAITAGMAFEAMSHAGDIHSDMLVILNDNEMSISENVGGLNNHLAQLLSGKLYASLREGGKKAFSALPPIKDLLKRTEEHLKGMVVPSTLFEELGFNYIGPVDGHDVHTLTQTLKNMRDLKGPQLLHIMTKKGKGYAPAEKDPIGWHAVPKFDPASGTLPKSQSSLPTYSKIFGEWLCETAAKDSKLMAVTPAMREGSGMVRFSREYPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQLIHDVAIQNLPVLFAIDRGGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYHHNGPAAVRYPRGNGTSAVLEPLEMLPIGKGVLRREGEKIAILCFGTLLAQAQLAAENLNATLVDMRFVKPLDEELVLEMAAKHQVLVTVEENAIMGGAGSGVNELLMAKRRWVPVLNIGLPDLFVPQGEQDEMRSELGLDAAGIQRQIEAWLA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: COBS_PYRIL
Sequence: MRCLKAVVAFFTALPVGGAELDFSCIWATPYLAGLMVGGAGGAVYFLTHSPAAAYAALLLATGLHHLDGLADVGDALMVRDRERARRVLEDPRRGVGGIFAVVALFVLAASARPESWLDYIVTDLYSKALALVVAAYSKPFKEGLGSLFIVSAKRQWPAALPALAVAAWLHPAAFLAATVLSLFFYVAAYKHLGGANGDLLGALLEVTRALYLATVDLSTSLINGLF
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FUT9_BOVIN
Sequence: MTSASKGILRPFLIVCIILACSMVCLFIYIKPTNSWIFSPMESASSVLKMKNFFSTKTGDFNETTILIWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVFEVPNKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVTDKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN
What is the function of this protein?
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth.  Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis.  Furthermore, it is capable to synthesizes Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis.  May also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.
What are the official names of this protein?
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9, Fucosyltransferase 9, Fucosyltransferase IX, Fuc-TIX, FucT-IX, Galactoside 3-L-fucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Golgi apparatus membrane.
Protein: NDK_STRU0
Sequence: MEKTFFMIKPDGVRRGLIGEVLQRIERRGFTLDALQLVTPSREHLDEHYHQLKDKAFYPGLIDYMMSGPILIGVISGNEVIESWRTMMGKTNPKDAAPGTIRGDFAQAPDENGEMMNVVHGSDSRDSAKREIELWLGHLTAENK
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_STAAN
Sequence: MVKVANKYAKALFDVSLDTNNLETINEELTVINEAVKDKIEQLKMVDSNPTQTAEQRRELINGVFTDINPYIKNMMYVLADNRHISLIADVFKAFQSLYNGHYNQDFATIESTYELSQEELDKIVKLVTQQTKLSKVIVDTKINPDLIGGFRVKVGTTVLDGSVRNDLVQLQRKFRRVN
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HTHR_MYCBO
Sequence: MTTRPATDRRKMPTGREEVAAAILQAATDLFAERGPAATSIRDIAARSKVNHGLVFRHFGTKDQLVGAVLDHLGTKLTRLLHSEAPADIIERALDRHGRVLARALLDGYPVGQLQQRFPNVAELLDAVRPRYDSDLGARLAVAHALALQFGWRLFAPMLRSATGIDELTGDELRLSVNDAVARILEPH
What is the function of this protein?
Negatively regulates the expression of sulfate ester dioxygenase Mb3440 and its own expression.
What are the official names of this protein?
HTH-type transcriptional regulator Mb3439c.
Protein: RIMP_SULNB
Sequence: MNLEAQISKIVEANGAALYDIETANEFDETIYRVLITKTGGVNLDLCATISNELSPFLDVHPPMNGHYRLEVSSPGIERKLSKPIHFQNAIGEKVKVKLLGGDKLKGVLKAADDKGITVETKQGEESYSYSDLGTVKTYFEW
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_MYCMM
Sequence: MSSIEPWPAPFAPTPVHATVTVPGSKSQTNRTLVLAALAAAQGQGSSTITGALRSRDTDLMIEALQTLGLRVDGTGSELTVSGRIRPGPEARVDCGLAGTVLRFVPPLAALSAAPITFDGDEQARARPIAPLLDALRGLGVPVDGAGLPFRVQGTGSVAGGTVAIDASASSQFVSGLLLSGASFTDGLTVQHTGSELPSAPHIAMTVQMLRQAGVDVDDSIPNRWLVRPGALRPRHWDVEPDLTNAVAFLAAAVVTGGTVTITGWPADSVQPAKNILDILQTLNSTVRHIDSCLQVQGPQTYRGFDVDLRDVGELTPSVAALAALASPGSVSRLAGIAHLRGHETDRLAALSTEINRLGGNCEQTSDGLVITATPLRPGSWRAYADHRMAMAGAIVGLRVAGVEVDDIGATSKTLPEFPQLWTEMVEGSSG
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHD_BACCR
Sequence: MKEIGALQAEYPLVNKLIATEEVFWINPNIEKYETAIKDSPLNEENVKDAEERLKRFAPYIAKVFPETKGANGIIESPLVKIPSMKEALERKYEQPILGELLLKCDSHLPISGSIKARGGIYEVLKHAEQLALQHGMVTEEDNYSVLDSDTCREFFSKYSIAVGSTGNLGLSIGIMSANLGFNVTVHMSADAKEWKKDLLRSKGVNVIEYEDDYSKAVEEGRRQADADPSCYFVDDENSHDLFLGYAVAASRLQKQLEELEVVVDENHPLFVYLPCGVGGGPGGVAFGLKLLYKDNVHCYFAEPTHSPCMLLGLMTGLHDKISVQDIGIDNVTDADGLAVGRPSGFVGKTMEPFLSGNYTVSDEELYRLLKELADTENIYLEPSALAGMIGPVKVCKEDEYLQKLQLTEKVKKGTHIVWGTGGSMVPNDTMDEYYRKGLELTI
What are the official names of this protein?
Probable D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: HEMA_I76AH
Sequence: MKKVLLFAAIIICIRADEICIGYLSNNSTEKVDTIIESNVTVTSSVELVENEYTGSFCSIDGKAPISLGDCSFAGWILGNPMCDDLIGKTSWSYIVENQS
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: RPOB_BACLD
Sequence: MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEGLREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKETGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTATVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEIIDLIGENEYLRNTLDKDNTENTDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLASVGRYKINKKLHIKNRLFNQRLAETLVDPETGEILAEKGAILDRRTLDKVLPYLENGIGFKKLYPNGGVVEDEVTLQSIKIYAPTDQEGEQTINVIGNAYIEEGVKNITPSDIIASISYFFNLLHGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLINIRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSFAKVNRFGFIETPYRRVDPETGKVTPRIDYLTADEEDNYVVAQANARLNDDGSFVDDSIVARFRGENTVVPKDRVDYMDVSPKQVVSAATACIPFLENDDSNRALMGANMQRQAVPLMQPESPIVGTGMEYVSAKDSGAAVICRHPGIVERVEAKNIWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVEKGEILADGPSMEKGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESEARDTKLGPEEITRDIPNVGEDALRNLDERGIIRVGAEVKDGDLLVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGGGGIILDVKVFNREDGDELPPGVNQLVRVYIVQKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVLELHLGMAARRLGLHVASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRVSVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILSSDEEEIEMRDLEDDEDAKQNEGLSLPNDEESEELVSADAERDVVTKE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: GATB_FUSNN
Sequence: MIKEWESVIGLEVHLQLKTGTKVWCGCKSDYDESGINLHTCPICLGHPGALPKLNKKVVDYAIKAALALNCQINNESGFDRKNYFYPDAPKNYQITQFEKSYAEKGYLEFKLNSGRQVKIGITKIQIEEDTAKAVHGKNESYLNFNRASIPLIEIISEPDMRNSEEAYEYLNTLKNIIKYTKISDVSMETGSLRCDANISVMEKGSKVFGTRVEVKNLNSFKAVARAIDYEIGRQIELIQNGGKVDQETRLWDEENQITRVMRSKEEAMDYRYFNEPDLLKLVISDEEIEEIKKDMPETRLAKIERFKNNYSLDEKDAFILTEEVELSDYFEEVVKYSNNAKLSSNWILTEVLRILKHKNIDIEKFTISSENLAKIIKLIDKNTISSKIAKEVFEIALDDSRDPEIIVKEKGLVQLSDTSEIEKMVDEVLANNQKMVDDYKSADEGRKPRVLKGIVGQVMKISKGKANPEIVNDLIMEKLK
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: GLMM_ECOSM
Sequence: MSNRKYFGTDGIRGRVGDAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSALFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDAVEEAIEAEMEKEISCVDSAELGKASRIVDAAGRYIEFCKATFPNELSLSELKIVVDCANGATYHIAPNVLRELGANVIAIGCEPNGVNINAEVGATDVRALQARVLAEKADLGIAFDGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKMQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMARNHMSLHDLCSGMKMFPQILVNVRYTAGSGDPLEHESVKAVTAEVEAALGSRGRVLLRKSGTEPLIRVMVEGEDEAQVTEFAHRIADAVKAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: CTHA2_CONVC
Sequence: MGRRDSGRAVAQRYRGVTRGVTVIACLMVVCACVGLCDATGQKRHSWEAPGCHLVGHTRVVRIPDCVPFQITTNACRGFCVSYAIPSPYQTLVYNPNHIITSRAACCDIIDTLDIPVQVTCVDGVREIVFKSARSCACSICRRE
What are the official names of this protein?
Thyrostimulin alpha-2 subunit.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit alpha family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS21_RHOPS
Sequence: MQVLVRDNNVDQALKALKKKMQREGIFREMKLRGHYEKPSEKKAREKAEAVRRARKLARKKLQREGLLPMKPKPAFGADRGRPGAAGAGAGAGAGPRGPR
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: YBEY_SHEFN
Sequence: MSQQGISLDLDLQIAVDNPRLPTQAEFETWVRAAIGQTKPVVELTIRIVDIAESQQLNSTYRGKDKPTNVLSFPFEAPPEVELPLLGDLVICAPVVEQEAIEQNKPLIAHWAHMVIHGSLHLLGYDHIIDEEADEMESLETQLVEGLGFDNPYKEA
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYCLF_ANNCH
Sequence: PGMGIYLPM
What is the function of this protein?
Probably participates in a plant defense mechanism.  Has cytotoxic activity against human nasopharyngeal carcinoma with an IC(50) of 60 nM.
What are the official names of this protein?
Cyclopeptide F.
Protein: PAK6_MOUSE
Sequence: MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSSVPTEGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDDQWAADPDMYLQSPQSEHTDPHGLYLSCNGGTPAGHRQVPWPEPQSPQALPNGMAAKAQSLGPAEFQGASQRCLQQLGACLQSSPPGTSPPMATGRRGVKVAKHSSEEARPQSCLVGSAIGRPGGEGSPSPKNQESSLKHRLFRSMFLSTPATGAASSSKPVPLPQNKPNSAFRPPQKDSSSNLVAKAQSLPSEQPMGTFSPLTTSDTSSPQKSLRTAPAAGPLPGRSSPAGSPRTRHAQISTSNLYLPQDPTVAKGALGGEDTGIVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
What is the function of this protein?
Serine/threonine protein kinase that plays a role in the regulation of gene transcription.  The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6.  Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription.  Inhibits also ESR1-mediated transcription.  May play a role in cytoskeleton regulation by interacting with IQGAP1.  May protect cells from apoptosis through phosphorylation of BAD (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PAK 6, p21-activated kinase 6, PAK-6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Protein: HIS7_STACT
Sequence: MSYRKQRETKETAIDIRMDLNDNQASSINTGVGFLDHMLTLFSFHSGINLQINVQGDTEVDDHHTTEDIGIVLGQLLLEAIKDKQSFTRYGAFYIPMDETLARVVTDISGRPYLSFNAEFSKEKVGTFDTELVEEFFRGLVINARLTTHIDLIRGGNTHHEIEAIFKAFARSLKIALSDDGSKGVPSSKGVIE
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLM_ECOL5
Sequence: MGKTQPLPILITGGGRRIGLALAWHFINQKQPVIVSYRTHYPAIDGLIKAGAQCIQADFSTNDGVMAFADEVLKSTHGLRAILHNASAWMAEKPGAPLTDVLACMMQIHVNTPYLLNHALERLLRGHGHAASDIIHFTDYVVERGSDKHIAYAASKAALDNMTRSFARKLAPEVKVNSIAPSLILFNEHDDAEYRQQALNKSLMKTAPGEKEVIDLVDYLLTSCFVTGRSLPLDGGRHLR
What is the function of this protein?
Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin.  Also has lower activity with dihydrofolate.
What are the official names of this protein?
Dihydromonapterin reductase, H(2)-MPt reductase, Dihydrofolate reductase, DHFR.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily.
Protein: PROBP_OLEEU
Sequence: MSWQAYVDDHLMCDIEGHEDHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFSEPGHLAPTGLHLGGTKYMVVQGEAGAVIRGKKGSGGITIKKTGQALVFGIYEEPVTPGQCNMVVERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-2, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: XYLR_CALBD
Sequence: MGNHTLLKQINKLLVLKTILDNKIISRTKISKLVDLNKATVSNLTDELIKEGYVVEKGYGKSKGGRRPVLLQVNKDVGSIIGIDLGVDYIHIILSNFVGEVIFEEYANMKIGEDKEKLLRLLFDLIEKSVKKAPQTPKGILGIGIGVPGIIEKESGTVLLAPNLKWQNVPLRSIVQQKFNLPVYIDNEANAGALGEKWFGEWGKVSDLIYLSVGIGLGAGIIIDNKLFRGAAGFAGEVGHTTINFQDDVCSCGNIGCLENFASERALLSVIKKLVKQGVEDRYISWENVDEITPSRIIQAAKEGSRVCRMAILEVAEKMGIGVANLVNIFNPEMVIIGNKASFFGELFLEKLREVINQRSFIAQFYNLKIEVSKLKDRAVVLGCIAMVISDMLSFPEYA
What is the function of this protein?
Transcriptional repressor of xylose-utilizing enzymes.
What are the official names of this protein?
Xylose repressor.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family.
Protein: SRP19_METBU
Sequence: MREKGKLVIWPANLDKSRSRKGGRIISRKSSLEAPLLRELTAAAEKLNLNPEVEADKKYPRTWWESSGRILVDNNEAKTMVARKIAKTIKEARGG
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
What are the official names of this protein?
Signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_TROW8
Sequence: MTKQETVKHLVGVLSDAQAIVFTEYRGLSAAQLRALRILLRGDASYLIAKNTLARIAAQQVGFNDFAEFLRGPTAIVAVDGDIVSVAKSLRKFAETDGLLKIKGCFVDGQVFGSEHVKRLAELESREVILAKIASVTKGALSSALGLVSAPLSSAARVFVAMKNTF
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: CP179_ORIVU
Sequence: MDISISWVVIIVSVLSYLILMDKWRAAKLPKNIPPGPPKLPSIGHLHLLRGGLPQHLLRGITQQYGPVAHVQLGELFSVVLSSTEAARQAMKVLDPNFADRFVDIGSRIMWYDSEDIIFSRYNDHWRQIRKICVSELLSPKNVRSLGYIRQDEMASLIRLFESSEGKPVNVSEEISKTVCTIVSRVAFGSAVKDQSLLLNLVKESLRMASGFELADLFPSSWLLNLLCFNKYRLWRMRARLDNFLDGFLEEHRVKKSGEFGGEDIIDVLYRMQKDSQMKVPITNNGIKGFIYDVFSAGTDTSAATILWALSELTRYPEKMAKAPAEVRESLKGKTSVDLTEVHELKYLRSVVKEALRLHPPFPMTPRLCVQESEVTGYTIPANTRILINVWSIGRDPLYWEDPDTFNPDRYDEVPRDIIGNDFELIPFGSGRRICPGLHFGLANIEVPLAQLLYHFDWKLPPGMTAADIDMTEKTGLSGPRKNPLILVPIIHNPTS
What is the function of this protein?
Involved in the biosynthesis of phenolic monoterpenes natural products thymol and carvacrol which have a broad range of biological activities acting as antimicrobial compounds, insecticides, antioxidants and pharmaceutical agents (Ref. 1, PubMed:26156773).  Catalyzes probably the C3-hydroxylation of gamma-terpinene to produce thymol (Ref. 1).
What are the official names of this protein?
Cytochrome P450 71D179, Gamma-terpinene hydroxylase, Thymol synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: COAD_TREPS
Sequence: MKAIFAGSFDPPTFGHLDLVLRARSLFAEVHVLVAVNVQKRYLLSECERVDLMRQVLGDRPGVYVFPWRSLVVTYARDVGARVLVRGVRNATDFCQEFDLAWVHRALDAGLETVFLAAKPCYAALRSSMVREVASFGGDVSTFVPRVVARLLQEKFTQA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.