PharMolix/UniProtQA huggingface dataset:
Protein: HXK1_ARATH
Sequence: MGKVAVGATVVCTAAVCAVAVLVVRRRMQSSGKWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYLEDS
What is the function of this protein?
Fructose and glucose phosphorylating enzyme (PubMed:7610198).  May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (PubMed:16920781).  Acts as sugar sensor which may regulate sugar-dependent gene repression or activation (PubMed:9014361, PubMed:12690200, PubMed:26528314).  Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism (PubMed:9014361, PubMed:12690200).  May regulate the execution of program cell death in plant cells (PubMed:16920781).  Promotes roots and leaves growth (PubMed:26528314).  Together with sugar, is involved in the regulation of the expression of aquaporin genes, and reduces leaf water conductance, to coordinate sugar levels with the loss of water through transpiration (PubMed:28390076).  Regulates cell proliferation and expansion early during leaf development (PubMed:30511331).  Involved in sucrose-induced leaf growth stimulation independently of GPT2 (PubMed:30511331).  May participate to the stimulation of hypocotyl elongation under long-day (LD) conditions (PubMed:34155329).  Forms a nuclear complex with CLF and EZA1/SWN to target common glucose-responsive genes and regulate glucose signaling (PubMed:35394700).  Is required for CLF- and EZA1/SWN-mediated histone H3 trimethylation on 'Lys-27' (H3K27me3) and glucose-mediated gene repression (PubMed:35394700).
What are the official names of this protein?
Hexokinase-1, Protein GLUCOSE INSENSITIVE 2.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Nucleus.
Protein: TRFE_GADMO
Sequence: GIKEADATECILAIKAGEADAITLDGGEIYTAGQHPYDLQPIISEKYGSGSSCYYAVAVVKKDTGFSFKQLRGKKSCHTGIGKTAGWNIPIGTLLTTGQLVWSGQEDLPVESVSTFFSKSCVPGAGGLVGGKLCTLCPSDCSKSATNPYFGYAGAFKCLKDDAGDVAFINHLTVPASEKANYELLCLDGTRAPIDSYKTCNLARVPAHAVVSRVDPELAERIFTALTTVTGFSFFSSAGFGAANLMFKDTTQSLVRLPDGSNSFLYLGAKYMASIQSLKKESDQPITPAIKWCAVGHAEKKKCDSWSSFSVSDGVKSVACQISLTVEGCFQRIMRQEADAMSVDGGQVYTAGKCQLIPAMVEQYNQSLCSSAGTPQATYFAVAVVKKGSGVTWDNLRGKRSCHTGLGRTAGWNIPMGLVHSIHGSCDFGGFFPSGCAPGSEPSSTFCRQCAGSGSGVEDGSKCSASSVEKYYGYAGAFRCLVDGAGDVAFIKHTIVADNSDGQGPAWATALKSSDYQLICPGGVGRAEISDFASCNLAAVPSHAVVTRQDIRDDVVKMLLDQQRKFGIDGSDPLFRIYESKDGNNLLFKDSTKCLKEIPSLTTADAFLGTGYVNAIMSLRQCPETASELEKTCISSSCSTAE
What is the function of this protein?
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
What are the official names of this protein?
Serotransferrin.
What is the protein family that this protein belongs to?
Belongs to the transferrin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HMUV_PSEE4
Sequence: MLDVEGLHLKRGSSEVLSDIRLQLRPGQILGVLGPNGAGKSSLLGALCGELSPSAGQVRLDGRDLHAWPGQERARRLAVLPQASSLGFAFSVEEVVGLGRLPHASGRQRDREIVEAALAAADAGHLASRSYLALSGGERQRVHLARVLAQLWPGEAGTTLLLDEPTSALDPLHQHTTLQAVRSFADRGAAVLVILHDLNLAARYCDHILLLEHGRSHALDTPQRVLTPAALNAVFGIDVLVQPHPERGHPLIITR
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PLIG_ECOLI
Sequence: MKIKSIRKAVLLLALLTSTSFAAGKNVNVEFRKGHSSAQYSGEIKGYDYDTYTFYAKKGQKVHVSISNEGADTYLFGPGIDDSVDLSRYSPELDSHGQYSLPASGKYELRVLQTRNDARKNKTKKYNVDIQIK
What is the function of this protein?
Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium.
What are the official names of this protein?
Inhibitor of g-type lysozyme.
What are the subcellular locations of this protein?
Periplasm.
Protein: Y14E_BPT6
Sequence: MAKVDIDIVDFEYIEEIIRNRYPELSITSVQDSKFWSIQIVIEGPLEDLTRFMANEYCDGMDAEDAEFYMGLIEQ
What are the official names of this protein?
Uncharacterized 8.8 kDa protein in frd-Gp32 intergenic region.
Protein: SC5A2_HUMAN
Sequence: MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
What is the function of this protein?
Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1.  Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493).  Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).
What are the official names of this protein?
Sodium/glucose cotransporter 2, Na(+)/glucose cotransporter 2, Low affinity sodium-glucose cotransporter, Solute carrier family 5 member 2.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: ARGB_PROM3
Sequence: MESAKSAAALVEPCQTNSARRLTEDDSLRVSVLSEALPYIQRFSGRRIVIKYGGAAMAHANLQEAVFRDLALLVSVGVEPVVVHGGGPEINQWLERLEIPAKFRDGLRVTDADTMDVVEMVLVGRVNKQIVNGLNQLGAKAVGLSGSDGSLVEARPWGDGSHGLVGDVARVNTDVLEPILAKGYVPVISSVAATVEGCSHNINADTVAGEIAAALEAEKLILLTDTPGILLDRDDPSSLVHQLRLSEARQLIAEGVVAGGMTPKTECCIRALAQGVGAAHIIDGRVPHALLLEVFTDAGIGTMVVGRS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_STAAM
Sequence: MEWSQIFHDITTKHDFKAMHDFLEKEYSTAIVYPDRENIYQAFDLTPFENIKVVILGQDPYHGPNQAHGLAFSVQPNAKFPPSLRNMYKELADDIGCVRQTPHLQDWAREGVLLLNTVLTVRQGEANSHRDIGWETFTDEIIKAVSDYKEHVVFILWGKPAQQKIKLIDTSKHCIIKSVHPSPLSAYRGFFGSKPYSKANAYLESVGKSPINWCESEA
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_NITHX
Sequence: MTASIIDGKVIAADLRARVAFEVARVKRDHGLTPGLAVVLVGSDPASEVYVRSKHKQTQAAGMASFEHVLPADVAQPDLLALVARLNADPAVHGILVQLPLPKGLDTETIVAAIDPAKDVDGLHPHNAGRLAGGLPALSPCTPLGCIILTKSVHSSLEGMDAIVIGRSNLVGRPLVQLLLNENATVTIAHSRSRNLPELCRRADLVYAAVGKAEMVRGDWLKPGATVIDVGITRRPAADGKTRLIGDVAFDEAMEVAGAVTPVPGGVGQMTVACLLVNTLRAACAIKGLPAPGV
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL5_BRASB
Sequence: MAETAYTPRLRTEYDRKIKSALTEKFGYANVMQVPRLDKVVLNMGIGEAVNDRKKAETAAADLSLIAGQKAVVTYSRVAIATFKLRENQPIGCKVTLRKAKMYEFIDRLINVALPRVRDFRGLNPKSFDGRGNYSLGIKEHIIFPEIDFDKAGESWGMDITVCTTAATDDEARALLTAFNFPFRQ
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: IOLC_LISIN
Sequence: MNLNKHSERKFDLITVGRACIDLNAVEYNRPMEETMTFSKYVGGSPANIAIGTAKLGLKVGFIGKISDDQHGRFIEKYMRDLNINTDGMVKDTAGRKVGLAFTEIKSPEECSILMYRENVADLYLTPEEISEDYIKETRVLLVSGTALAQSPSREAVLKAVHLAQKNDVIVAFELDYRPYTWKNTEETAVYYSLVAEQADVIIGTRDEFDMMENQIGGNNEMTIDNLFKHKAEIIVIKHGVEGSFAYTKAGETFRAQAYKTKVLKTFGAGDSYASAFLYGLFSGENIETALKFGSAAASIVVSKHSSSDAMPTADEIKALIANAD
What is the function of this protein?
Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).
What are the official names of this protein?
5-dehydro-2-deoxygluconokinase, 2-deoxy-5-keto-D-gluconate kinase, DKG kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: C1D_CRIGR
Sequence: MAGGEMNEDYPVEIHESLSALESSLGAVDDMLKTMMSVSRNELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAAKLDRGAASRFVKNALWEPKQKNTPNVANKGKSKH
What is the function of this protein?
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5. 8S rRNA; this function may include MPHOSPH6.  Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA.  Can induce apoptosis in a p53/TP53 dependent manner.  May regulate the TRAX/TSN complex formation.  Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
What are the official names of this protein?
Nuclear nucleic acid-binding protein C1D.
What is the protein family that this protein belongs to?
Belongs to the C1D family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization. Colocalizes with TSNAX in the nucleus.
Protein: SNX27_RAT
Sequence: MADEDGEGIHPSTPHRNGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNGVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPTYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGATVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVINHSFVRKLAPNEFPHKLYVQNYTSAVPGTCLTIRKWLFTTEEEVLLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKENIFQMARSQQRDVAT
What is the function of this protein?
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.  Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes.  SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling.  SNX27 also binds with the WASH complex.  Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)).  May participate in establishment of natural killer cell polarity.  Recruits CYTIP to early endosomes.
What are the official names of this protein?
Sorting nexin-27, MAP-responsive gene protein, Methamphetamine-responsive transcript 1 protein, PDZ-protein Mrt1.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products (By similarity).
Protein: RS6_VIBVU
Sequence: MRHYEIVFMVHPDQSEQVAGMIERYTGSITEAGGKIHRLEDWGRRQLAYPINKLHKAHYVLMNVEADQAVIDELETAFRYNDAVLRNMIMRTKAAITEPSIMLKQKEERAPRREAEAKEFAAE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PUR7_STRR6
Sequence: MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEEARRINELLKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEIVWEKLQELK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: GLMU_GLUOX
Sequence: MTDSTHRTTAIILAAGLGTRMKSRLPKALHRLGNQPMINHLITTARQVFDDVVVVTGPDMPELEKAVRPFKTVTQVERLGTAHAANTARDLFGTGDVAILYADNPLITAETMRRLLAARREGASLALLGMRPAEPGRYGRIVEDHGRVVKIVEFKDATEDERRITLCNAGVMCAGVDDFRTWLANVGNDNAQGEYYLTDVVEMAAKAGPVVCVEAPEAELAGVNSRSELARAEATLQTRLRNAAMDAGVTLVAPETVFFSTDTVIEADVTIEPNVFFGPGVKVRSGALIRAFSHLEGCEVGENAMIGPYARLRPGTLCAAQTHVGNFVELKNVELGEGAKANHLTYLGDASIGSGTNVGAGTITCNYDGVFKHRTTIGERVFVGSDSILVAPVTVGDDALIAAGSVITSDVPPGDLALGRARQTLKSGQGLQIKQSLKARKEQG
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_STAPU
Sequence: MKDSREKLIKRFLCAKTNTKIVNQENKLYYFFLHEDLYPIIFQNTDSSFGKFSSVFRKTNIKKNHRESFLTIKSCIFLFRSNNFSGRKRSFFSNTRFHDQKKKENFLPLPKKVIFSLFFESITFILLCNQKKSDFEKQFFQTKDLSISIQKPLASLERQWQYDSFGFQGCFSYFFHPEVVLRILRKKFQDISFLHLLRKFLHLNVYLSNNTVKEVPTNNIRTILWNIYFLEIDSFFVSICKNYCISDEINNVSSNYSLSCFEKIQEWTYFVEKQEYKDFFEKKLYPYEIFDTITIRNSEERRLEQSIKRQISFLDQSKIYKYFRTNTNWFIFFQKQKPENILLKRWIILFFIRRLGYILQENTINWTLTFSEYQNELSAYFFLAYILQFPKKKNFVKINTKLFFLVHYFVRRVISFLNPLYLIILLLSKQNFCNSFGYPKSKSGWVTWTDTDIIQNFTRLQNNLFFFYSGCTNTKALARIHYILHFSCVKTLACKHKTNLRYIYKKFGTNLTRKDFTTKIFVTNQSKNFRLRSLWKNQKMTRVWNFRLTQLNSLIFHLETFYRLR
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: COBQ_ALISL
Sequence: MNTFAPLMVQGTTSDAGKTVLVAGLCRVLSNKGIQVAPFKPQNMALNSAVTEDGGEIGRAQALQADAARVKPHVHMNPILLKPNTDIGAQVIVQGKAIETMDAWGFQDYKKLAMPYVLESFAYLNDHYQCVVVEGAGSPAEINLRENDIANMGFAEAADVPVIIVADIDRGGVFAHLYGTLALLSESEQARVKGFVINRFRGDISLLVPGLEWLEEKTGKPVLGVIPYLHGLNLEAEDAIKSEQQEKGQFVVKVPVVTRISNHTDFDSLRLHPDIDLQFVGKGQSLSGADFIILPGSKSVQADLNYLRSQGWDKDIERHLRFGGKVMGICGGYQMLGEQLSDPLGIEGEPSLIDGLGHLAISTELKKQKQLTLVEGELHLPNQSSAKVKGYEIHAGVSIHTAGAHLPVIINSESIVRYDGALNHEGSIFGTYLHGIFDEPEAFEAIMSWAGLKESKAIDMKEIQEEAIERIAASIEESLDLSQLWPSLFEKKAAY
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: ATR_ENCCU
Sequence: MNRDYLKNLYLQRLESERYSDVFRESMSSLVSTEIINAVISLAVQDDDETMLVDLLELFLQNLESNVVFHEKLTKSSFHLLLFKRPLGIQSYTKLKSIYDRVGSRRVVPGFEHTEFLSKNFYNYCLYKHAYKDYQFDLELDAGSLGPVETNLFKDLLKAVCIENRENEHLANYIKTLPMDVSVFLAIVMPDFRIDASRLGPEDVFLVCPSQVRGYDPKQFTKAFLCSLNSEGGLCRVCGRRVLGCGFEEIDREEYLDSVSGNIEEMCFGVSHWEKIRTPRMLTTILRSLFKRPGCLECYKCLRYFPIEEQGEMEDIVLRFLRYAASILSIGNIQVSLRMFPFIRHTPRVVFSYFVILFEGFLKYSGNLFLKNVIRNVSTRNKAKFMGVRAMIFEYYLKGSIESASSTEENTKNEGGSGAVENPGRKRADDLGDLFAPLSEFFDEERKAFVRNNMFYIYPIMYSLSFPYYTPDLAFTQANNHFLIISLFLRGEESRIDEIGYGKDELYRMGVDVMIPLLCNGYFKYDVLSRFFGNVQEYIRAHLPKFLFALKKVYVERPFEFRVCVFKILKCIIEAISGNVRMLFNYLFPFVEFFMRSHEESCGTDCKMIFIEYYSSFFKNDCLVRNMSRIFPYLDAEKIARWSNVKSEDDYLDIVIGLLDTRGHFSQEMAAKKAVELLARVFGDPGKGKGFDEESFVENVLRRFFKSREFRMKIGNVYGKLKELGNDAAFLIGCISQEFLDANPLPSVCSVLIEECTPEAIARVMVEKYLFEMDPGKQDLHFFIIQETLRFIKGPLSDRMEEVVEQFRSTQYFYEYVPVHPVEGVYEKTYTFKRFLGRLYRYSLNEIAKSEMQEYFSLLKYGNLLDTLFLEFHCLCLCRLLLEAGDHKVLGMVREIANNLQEGVDKRIARFVLKLHGFTSGKHIEDQQILRISFFLKDHHNAIQTLEKMIRKERKSELFDLLQYCYYSIKDYDKVLGINSVFARPSLINLFFRFCVDKNFAAARRCLEPKPGHDGVKEESGEDHKGQAPRELDVKILMEEIIDECQDDEVTKFMNDCKKIEGDFSEWKRLESRNEVFKHFIKDCELVSKSKNLLKTLDLIAGRRELAGDNRMLLECHESLVASIRSMMDARDDMSCDEMFESLLTAEKQDTIGNSSQGLHSREYFDDFASVDMVRAERRSERIGYMDRSKSGSTSGYSSLEEFERDLKLAIIRNYRGDDDVGRCIQEIGGMLLKREWCVLYELAELNVLQGKIGDAKTSLKKVLEIFPKTSMLYKKALIRYSELLDTKTAYTSALSILKDSGKLFLLGAKKFESTEPVKAMEMYINSVIHDNQCSDEAVPRIFHLFSEMMPPGDINAGAVLLKKFLESSISLLPPYYNQILSRLSHPNQDVANVVSRIVFELMENYPSKTFWRSLIMMNSQVPSTRKRMEGIVSGLTLDNKVALSNVKRISEELTCISRSKKNELTMEEDFPAFAKMFPAGVTVPNTKVLISGVRNEVKVFNSLQRPKRICFVGSDGKNYYWLCKNQDDLRKDSRFMDLNLIINSILKKQSSRKYIRTYAVIPFSHESGIIEWIGGLSSLKAICDTYYARDGISISETACRFVHNKKIGMREWHRVASKFHPKFHLWFHDSFPHPFSWLVARNNYTQTYAIMNIVGWFMGLGDRHAENILFDSNTGDTVHVDLNCIFGKGKELQVPERVPYRLTQNIVDAFGVLGLEGSYNTSLCTTLDLFLKNKNILVSNLLSFVYDPLFEWRRKSATTPKKIIEDLWHKMDDLDACSKCDVLNEEATNDENLCMMYIGWLPFI
What is the function of this protein?
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor.  Recognizes the substrate consensus sequence [ST]-Q.  Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination.  Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism.  Required for cell growth and meiotic recombination (By similarity).
What are the official names of this protein?
Probable serine/threonine-protein kinase MEC1 homolog, ATR homolog, DNA-damage checkpoint kinase MEC1 homolog.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. ATM subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to nuclear DNA repair foci in response to DNA double strand breaks.
Protein: FMRF_BOMMO
Sequence: MNHPRSIAMLAALWLVVSVTSTPVRRSPDLEARRRSAIDRSMIRFGRSTLPVVPPAQPSFLQRYSAPQPAALTADDLMTFLRAYEEDYSSPVSKKSASFVRFGRDPSFIRFGRSVDEENSGYQAETNTYPQRRHRARNHFIRLGRDNELSESNDEDRYEVESERTKRSVVDPCNDCA
What is the function of this protein?
Regulates ecdysteroidogenesis by direct innervation of the prothoracic gland by reducing cAMP production via the receptor for myosuppressin.  The neurons that innervate the prothoracic gland during the fifth instar are most active during days 0-4, after which they reduce and then peak again on day 6.  Expression suppresses the biosynthesis of steroid hormones called ecdysteroids that elicit molting and metamorphosis.
What are the official names of this protein?
FMRFamide-related peptides, FaRPs, Bommo-FMRFamide, BRFa.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
Protein: HSLO_PROM0
Sequence: MQDRIVRATAANGGIRLVAVLTTESSLEAKKRHDLSYLTTCILGRAFSASLLLASSMKIMHGRVTLRVRSDGPLKGLLVDAGRDGKVRGYVGNPDLELDLVKIDSNKYSFDFTKALGTGYLNVIRDSGIGEPFTSTVELVNGNIAEDLASYLYHSEQTPSAVFIGEKIQNQGIICSGGLLAQVLPKKDTDPLLVSLLEERCKEVNSFSEDLFQSKDNLLSLIKKIFPDIDDESISEKARSQEVSFKCKCSKQRSLNAMNMLDKSELEDILKKDGNAELVCEFCKNKYLINYEEIKLMIENQS
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPZC_BACSU
Sequence: MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPFFAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL
What are the official names of this protein?
Uncharacterized protein YpzC.
Protein: DEGS_SCHPO
Sequence: MAESTATTTAVPPPAEESWNADSEDVHQFYWTYTEEPHKSRRAAILKAHPEIASLNGYEPLTKWIVLGVVSLQFTCAYLLSQSSLLSWKFFLTAYFIGAFCNQNLFLAIHELSHNLGFKKTLYNRAYCLFANLPVGAPFAASFRPYHMEHHAYQGVDGMDTDLPTRAELILFDNVLGKAFFCTFQLLFYAFRPLVVRRLPFTLMHFWNIIVQFSFDYLVVRYVGWRALAYFFMSSFLAGSLHPTAGHFLSEHYNMTRTRLIASGPGKETPLETFSYYGPLNFFVYNAGYHIEHHDFPYVAWTRIGKVRELAPEFYDNIPDCKSWCGIIYQFITDSNVGMWCRVKRKQKHADIPTKSMHLHVS
What is the function of this protein?
Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.  Required for sphingosine biosynthesis.
What are the official names of this protein?
Sphingolipid delta(4)-desaturase, Delta 4-(E)-sphingolipid desaturase, Dihydroceramide desaturase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL11_NEIG1
Sequence: MAKKIIGYIKLQIPAGKANPSPPVGPALGQRGLNIMEFCKAFNAATQGMESGLPIPVVITAFADKSFTFVMKTPPASILLKKAAGLQKGSSNPLTNKVGKLTRAQLEEIAKTKEPDLTAADLDAAVRTIAGSARSMGLDVEGVV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: GMT1_VANPO
Sequence: MSDLKLAENNFWGNVANSGPISIFSYCASSILMTVTNKFVVNLKDFNMNFVMLFVQSFVCTLLLVILKTLGYAKFRPFNKTDAKNWFPISVLLVIMIYTSSKALQFLAVPIYTIFKNLTIILIAYGEVIYFGGKVTSMELSSFILMVLSSVVATWGDKQAMQAKSLVESDVTVPVVPFNVGYLWMFANCISSAAFVLIMRKRIKLTNFKDFDTMFYNNVLALPILLLFSFCIEDWSSTNLSTSFTANSFTAMIISGMASVGISYCSGWCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPKNFLSIFSIFLGFLAGIVYAVAKQKKNQNPEK
What is the function of this protein?
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
What are the official names of this protein?
GDP-mannose transporter 1, GMT 1.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.