PharMolix/UniProtQA huggingface dataset:
Protein: SCX1_BUTOC
Sequence: GRDAYIAQPENCVYECAQNSYCNDLCTKNGATSGYCQWLGKYGNACWCKDLPDNVPIRIPGKCHF
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Alpha-toxin Bot1, Bot I, BotI, Neurotoxin 1, Neurotoxin I.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2179_LISMF
Sequence: MSQILFKTKTFWYGIALTFCIATLSYFLAKLPFLMILGQLVTAILIGIIIRALFPVPEKWFTGIQFSNKVILRAGIILLGFRLNLVDIYHAGWRVFLIAALCLSFGITIVYFLAKLFGVDKKLAILVACGTGICGAAAVVAISPQVKADNNQTAVAATIIALLGTIFTVIYTLIYPILPLGPDGYGIFAGATLHEIAHVIAAADPGGSSAVDMAVIVKLTRVALLVPVCFVVAKMVNAGTKNRFSWAELPVPWFIFGFLATSAINSFGIIPTSVTDFLVICAYFLIAMSMGGLGLNVHLPSFGKMGGKPFAAALIGSVFLSAFGLALVLLFHLAG
What are the official names of this protein?
UPF0324 membrane protein LMOf2365_2179.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL17_DEHMB
Sequence: MRHKVSGRRFDRPTGQRMSLYRNLVTDLLNYEEITISEPRAKEIRSMAEKMITLGKKGTLASRRRALAFVYMPGIVEKVFEDLSKRYAERPGGYTRMTKLGPRQGDGAEMVKLELIK
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: GDT6_DICDI
Sequence: MINKISRFKILLLFIFIISLTCAQDEELISTPEGYYDLKRFKRFQHYKNIQPNEEAGYTDLYYPDVCKNAIRNRDGAPTFNQRSFPGYTGVFDTLLITKGTNMTLDSTGFLTGLGIWSLLTLCVEGNLTVLYNPDEFSFVPVHRLVILPGGTITSHANSFLFWDTYQVDENFQEELNKRVKIDPFNFFPGLLVLGGNLNLFGNSQLTYTAKRLNDTTLELSTPFLNMKFLWNKYIITIFTESIPQGDDCLFNMDSDKRTFYLIKTNYGTCNPLRETDKLMKVVISYNRYEDNYSSYISLFSDYYGFEPNEASIFITGDSNVYIENYLIKNLGKTKNNAYSDTKLIFSPNNTSEVIGFINGTNQRFRSSLYIEFSNNVIIKNCVIIESSSETRSPLVFFGSNVYLSDNLISSKSGSSLIAQYGTENIQSINNFYFQKGVSHQTASQILNPINMDFGNEGNGIYSVSPNLLSSDDFFIGQNYSITFNFIANRSKITGFDQDCYAPCFSDSINFSNKIQYPVDFKIFNPKFLPTNNTNSDWYILNINDNGNQPGTYYTVKNLTTLDPVQFSLDNSALSFLGLEASENFKMNGNAKRLDIVNSIISSKALTNQQQIISKVSSSAISFKNSYIYSKLGQQITPIDNQIYGSLITPFYYNDSDILNQVKILSIFPNVPFQIVSGSILNVSINLQIISTADISCTFSSDNSTFSTTILVNPSDGSCVLPLVFEKEGYFNLKVTLKISTSKDYYYIVDFPKITVYNEYLFYSGWVMIDSSTDEFLFEGKIFKSGCQQQVLGNCTISTNSKFINGLPNVTETDELNRLFSSGITSINPYEPVTITIPIDKESKKNQIQLFFTHQPIDIEYSLLSIYVENQPIFLLEQLQSGLGSTFKNLTFNYENSKSLEIINISFTTRGDIYLTSMAVYSSAIPIIVTPTPTSTTSTPTPTSTTTSTPIPTTTPTTTPKTSKTTSKNKLKIALPICLFALLVAVGVLICFIFRKKKQKKQKLDNNMEDGSEMSSIKIKKENYNSFNKFKESTVFKNDDFKNYSNPTETTIYSTSDSLLNFVGSDFLNYSDPNIPLSFSKNILEFGLKGSKCDINTFLSDSLRITNNSNIILCICTVLPRNDSGEVNVSPDSFELDPNQSREIEFSLKLNCTTRFFERFAIEARHTHSFKSIHTHLFIHVESKISSKLDIKEIEVKELISQNNLSTVNIANYRGLQVVLRKIKTHSANYTKTYSQAIKKFYTEMDILSKLKNKNIVSFIGCTHDSSHLWIVTEYAPLGSLSSLIHQKKEKLSLIQKVKLMLDTAKGCEFLHSNDITNCNIKSNNLLLFSTMEKDDVCVKISDFGIKKFEVQNQNEKEIFKDEKDQKLIDVYEFGITFYETMLEETPENLSNLILEGERPTLDLEKLDADIRNIIERCWNQNKRSTFSEISISLKEKYTKLLEKNNELIQEN
What are the official names of this protein?
Probable inactive serine/threonine-protein kinase gdt6, Growth-differentiation transition protein 6.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RPOC_ACHLI
Sequence: MAKNEVLSLPVDSLKLSQTALDRLKLSGISRLEDFNTFNLKELQMLLSDSFNEVLPTLIYYKLPRDVRDLSLSDEVVSVLETAGIKDLEALTKYDKSTLYHVFKDDEFLLKEINDLFELYHEEKLSTLNVATEVFEEVALPQEVSVEDRVNKIIQPIRKTYGSKAFTHFKVRLASPDEIRNWSYGEVINHETINYRTSKPEPGGLFDERIFGPTRDYQCACGKKQTVNKGQICPKCGIEITESKVRRERMGHINLEAPVVHTWYLKNSPSRLAILLGIKAKQLEEVVYHASYIVTDPGQNTPLAKKQILSEQDYSLLVEEYGSRFTALTGAEAVKKLLQDLDLDKEVKNLRKRLKTSSKQKRDRIIKRLDVVEAFNQSDNKPEWMVMDVIPVIPPDLRPMVPLDGGRFATTDLNDLYRRILNRNNRLKKQKEQMAPRLITKNEKRMLQEAVDALFDNAKRGKKAAVERNRHLKSLSDLLRGKQGRFRQNLLGKRVDYSGRSVIIVGPDLEMYQCGIPREMAITLFKPFILRELQLTHGAEKKNANAKYERRDDDTWRALEKVVREHPVLLNRAPTLHRLGIQAFEVKLIDGKAIRLHPLVTPAFNADFDGDQMAVHLPLSPEAQAEARLLMLASNNILNPRDGKPVVTPSQDMVLGNYYLTIEESKDRNFGDDLERTKKHQEKHRHEGKFFSSIDEVKIAYENKDISLHTRIIIKPESVKDTFTVEQKNMYLVTTLGKIIFNEILPETFPYVNEPTMSNLSEKTPDIYFIKKGVNPKDALKHIPTPEPFKKRFLSMVIAQVFKLFHISETSRMLDKLKDLGFKYSTVAGITISYADINVYSKKKEMVEATEEEINEIEEWFEDGLLTDSERRKLVIDKWTNVKNEIQSGIMKEFDKDNNIFMMSDSGARGNVSNFTQLVGMRGLMSNPKGETIEVPVQSSFREGLTVSEFFISTHGARKGSTDTALKTAESGYLTRRLVDVSQDVIIVEDDCGSSHGVYVEAIKDESGKEIVPLYDRIYGRFAAHDIISPKTGEVFVKRNELITEEIGLAIVKSGMQKVEIRSIMTCTSSHGICAKDYGINLATNQFVEVGEAIGVVAAQSIGEPGTQLTMRTFHTGGVAAGADITQGLPRIQELFEARNPKGKATISEVEGKVKDISRRGGSISITITDTQGTEYKYTLDPNIEALVKKGQDVVAGQKLSSGSINPKELLRVTDVKTASNYILEEVQKVYRAQGVEISDKHVEVIIRQMLRRIMVIIEGDTNILPGTEVSIDEFKRENKEVLKNRGRLAVGRPILLGITRASLRSDSFLSAASFQETTRILTDAAIRSKKDELHGLKENVIIGGLIPAGTGILQEKFFHYDQPEDKKPIYDDFE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RLMN_NEIMF
Sequence: MKTNLLNYDLQGLTRHFADMGEKPFRAKQVMRWMHQSGAQNFNEMTDLAKSLRHKLNEQAGIEIPKLMMSQKSSDGTRKWLLDVGTGNGVETVFIPESDRGTLCISSQVGCALECTFCSTGRQGFNRNLTAAEIIGQLWWANKAMGVTPKNERVISNVVMMGMGEPMANFDNVVTALSIMLDDHGYGLSRRRVTVSTSGMVPQMDRLRDVMPVALAVSLHASNDEVRNQIVPLNKKYPLKELMAACQRYLVKAPRDFITFEYVMLDGINDKAQHARELIELVKDVPCKFNLIPFNPFPNSGYERSSNENIRVFRDILQQAGFVVTVRKTRGDDIDAACGQLAGQVQDKTRRQQKWQQILIGQQG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAF_THEVL
Sequence: DVAGLVPAKDSPAFQKRAAAAVNTTAD
What is the function of this protein?
Probably participates in efficiency of electron transfer from plastocyanin to P700 (or cytochrome c553 in algae and cyanobacteria).  This plastocyanin-docking protein contributes to the specific association of plastocyanin to PSI.
What are the official names of this protein?
Photosystem I reaction center subunit III, PSI-F.
What is the protein family that this protein belongs to?
Belongs to the PsaF family.
Protein: PF38_PLAF7
Sequence: MKRWSIITGIVIIFCILTCKGQVENKKVDFRTEKGKFVPLNLVPGDVVEYSCPYSLNNDIRNMNGVEREHFDNKKFCFDYIFVGSKLTFLKEYVRGSYNVVHKEEGNLYTSQFSVPPVVLTHRNFDCFCYMEENNVVVKKVLRIHISNGVLRKIPGCDFNADYKESTAITTFSNMSPRRVKVCDVYPKSGDFISLMCPSDYSIKPDGCFSNVYVKRYPNEEVKEEDRFNLNRKWDASKYNVVSIETVLKMNMITQGDKYSIFSKLPDVKDQVDFTCICQSNDEQDNLMMNVYINNTSYLTNNTRSIGVNKHSFSNSEIFERIEREEISFAFSSYLSITLILLYLFFLNF
What are the official names of this protein?
Merozoite surface protein P38.
What are the subcellular locations of this protein?
Cell surface. Cell membrane; Lipid-anchor, GPI-anchor. Note=Present on the surface of merozoite.
Protein: CCMB_ECOL6
Sequence: MMFWRIFRLELRVAFRHSAEIANPLWFFLIVITLFPLSIGPEPQLLARIAPGIIWVAALLSSLLALERLFRDDLQDGSLEQLMLLPLPLPAVVLAKVMAHWMVTGLPLLILSPLVAMLLGMDVYGWQVMALTLLLGTPTLGFLGAPGVALTVGLKRGGVLLSILVLPLTIPLLIFATAAMDAASMHLPVDGYLAILGALLAGTATLSPFATAAALRISIQ
What is the function of this protein?
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
What are the official names of this protein?
Heme exporter protein B, Cytochrome c-type biogenesis protein CcmB.
What is the protein family that this protein belongs to?
Belongs to the CcmB/CycW/HelB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRD2_PONAB
Sequence: MAASGRGLRKAVAASPFPAWRRAHTEAGGGLKPEYDAVVIGAGHNGLVVAAYLQRLGVNTAVFERRHVIGGAAVTEEIIPGFKFSRASYLLSLLRPQIYTDLELKKHGLRLHLRNPYSFTPMLEEGAGSKVPRSLLLGTDMAENQKQIAQFSRKDAQVFPRYEEFMHRLALAIDPLLDAAPVDMAAFQRGSLLQRMRSFSTLKPLLKAGRILGAQLPRYYEVLTAPITKVLDQWFESEPLKATLATDAVIGAMTSPHTPGSGYVLLHHVMGGLEGMQGAWGYVQGGMGALSDAIASSATTHGASIFTEKTVAKVQVNSEGCVQGVVLEDGTEVRSKVVLSNTSPQITFLKLTPQEWLPEEFLERISQLDTRSPVTKINVAVDRLPSFLAAPNAPRGQPLPHHQCSIHLNCEDTLLLHQAFEDAMDGLPSHRPIIELCIPSSLDPPLAPSGCHVVSLFTQYTPYTLAGGKAWDEQERDAYADRVFDCVEVYAPGFKDSVVGRDILTPPDLERIFGLPGGNIFHCAMSLDQLYFARPVPLHSGYRCPLQGLYLCGSGAHPGGGVMGAAGRNAAHVAFRDLKSM
What is the function of this protein?
Probable oxidoreductase that may play a role as regulator of mitochondrial function.
What are the official names of this protein?
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the carotenoid/retinoid oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Note=The import into mitochondria is dependent on TOMM40 and TIMM23.
Protein: SYA_CLOBM
Sequence: MERMGLNEIREEYLKFFESKAHLRLPSFSLVPKNDKSLLLINAGMAPLKPYFTGLQVPPNKRVTTCQKCVRTGDIENVGKTSRHGTFFEMMGNFSFGDYFKEEVIPWAWEFTTEVLKLPKNKLYVTIYEDDDEALDIWVNKTDVDPKRIFRLGKEDNFWEHGLGPCGPCSEIHFNRGAGEVKTSEEFVKASDEDKIVEFWNLVFTQFDKDEEGNYNKLANPNIDTGMGLERMATIMQNVDTIFEVDTIKAVLDKVCKLSGANYKEDRVKDISIRIITDHIRSITFMISDGILPSNEGRGYVLRRLLRRAARHGKTLGINNTFLHNLTDIVIENCYKNYPELEEKREYIKKIIKLEEERFDETIDAGMQILNDYIKEVKNNNYKVLSGDKAFKLYDTYGFPVELTEEILEEEGISIDKEGFNKEMKEQRERARSAREETNYMGAEDTILNKIDLNINTDFEGYDKLEVKSKVAVIIKDEEFKNEIEKGNEGVIVTYNTPFYAEMGGQIGDTGIIYNDNFKAEVIDCKKNISGKILHFVKILDGKVALEDQVILKVNEGRRNNIRKNHTATHILHAALIKVVGDHVQQSGSYVDDERLRFDFSHFEAVSEDELKEVEKIVNKEIMKANAVNTKVMNIEEAKQQGAIALFDNKYKDDVRVVSVGDFSKELCGGTHVSNSGQIGMFKVVSEAGVAAGIRRIEAVTAFKAMEYVDHKNNILKEAAQILKCNEKELLNKLNHQVLEMKEKEKEIEALKLKLASGAEDEILNNIKEIKGVKVASAAVKDIDGNALRDLGDKIRDNMQSGVVVLGSNYKGKVLFVAMATKDTVAKGVHCGKIIKEVASIAGGGGGGRPDMAQAGGKDPNKLEDAIKTVETVVESLVK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WECA_SHIFL
Sequence: MNLLTVSTDLISIFLFTTLFLFFARKVAKKVGLVDKPNFRKRHQGLIPLVGGISVYAGICFTFGIVDYYIPHASLYLACAGVLVFIGALDDRFDISVKIRATIQAAVGIVMMVFGKLYLSSLGYIFGSWEMVLGPFGYFLTLFAVWAAINAFNMVDGIDGLLGGLSCVSFAAIGMILWFDGQTSLAIWCFAMIAAILPYIMLNLGILGRRYKVFMGDAGSTLIGFTVIWILLETTQGKTHPISPVTALWIIAIPLMDMVAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLASIGVLAEYSHFVPEWVMLVLFLLAFFLYGYCIKRAWKVARFIKRVKRRLRRNRGGSPNLTK
What is the function of this protein?
Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
What are the official names of this protein?
Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase, Undecaprenyl-phosphate GlcNAc-1-phosphate transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. WecA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CY1_EUGGR
Sequence: GVDSHPPALPWPHFQWFQGLDWRSVRRGKEVYEQVFAPCHSLSFIKYRHFEAFMSKEEVKNMAASFEVDDDPDEKGEARKRPGKRFDTVVQPYKNEQEARYANNGALPPDLSVITNARHGGVDYIYALLTGYGRPVPGGVQLSTTQWYNPYFHGGIIGMPPPLTDDMIEYEDGTPASVPQMAKDVTCFLEWCSNPWWDERKLLGYKTIATLAVIAVSSGYYNRFLSGLWRSRRLAFRPFNYSK
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.  Cytochrome c1 is a catalytic core subunit containing a c-type heme.  It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c.
What are the official names of this protein?
Cytochrome c1, heme protein, Complex III subunit 4, Complex III subunit IV, Cytochrome b-c1 complex subunit 4, Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit, Cytochrome c-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: ATG12_KLULA
Sequence: MNSGVLLSESETDTSEVSGRQSELISGDESIKGKLEEFSAKLNELRLADGNSDGGDEEESLSPDTKSQREESSENSENVSRSTSRPPLTSSIVSSVEREQLKSQVKVKIRLQPIGAIPQIQPRVCQISAHQQFLALTRFLCKRLKRKHIHCYINNAFAPSLDQNIGDLWTQFKVNDELIVSYCETVAFG
What is the function of this protein?
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.  Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function.  The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
What are the official names of this protein?
Ubiquitin-like protein ATG12, Autophagy-related protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG12 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: ACSA_SHEHH
Sequence: MSTQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSFDDHNLFIKWFYDGTLNASANCLDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHTQVCKFANALRSQGVRRGDVVTIYMPMVPEAAVAMLACARIGAIHSVVFGGFSPDSIASRVIDGNSKVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWDSLMDTASEHCIAEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEVYWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNYPSPARLGEMVDRHKVNILYTAPTLIRALMAEGKEQFAGFDGSSLRIMGSVGEPINPEAWRWYNDVIGHEKCPIVDTWWQTETGGILISPLPGATDTKPGSATRPFFGVQPALVDNMGNIVDGASEGNLVILDSWPGQMRTVFGDHDRFVLTYFKTFRGMYFTGDGAKRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHEFVAEAAVVGYPHDIKGQGIYAYVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAGGLPKTRSGKIMRRFLRKIAANEVSNLGDSSTLADPAVIDTLIETRLNRSE
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: ES2RB_PELRI
Sequence: GIFSLVKGVAKLAGKTLAKEGGKFGLELAMCKIAKQC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Esculentin-2Rb.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Esculentin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CRCB_SALAR
Sequence: MLQLLLAVFIGGGTGSVARWMLSMRFNPLHQAIPIGTLTANLLGAFIIGMGFAWFNRMTHIDPMWKVLITTGFCGGLTTFSTFSAEVVFLLQEGRFGWALLNVLINLLGSFAMTALAFWLFSAAAAR
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPO10_THEAC
Sequence: MIIPVRCFSCGRVIASDYGRYIKRVNEIKAEGRDPSPEEIEKIFDDLGIERYCCRRMIVSHVDLISEIMPFS
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit N.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU1_YERPE
Sequence: MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGSARAFDQIDNAPEEKARGITINTSHVEYDTPARHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFMNKCDMVDDEELLELVEMEVRELLSAYDFPGDDLPVVRGSALKALEGEAEWEAKIIELAGYLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKDTVKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREDIERGQVLAKPGSIKPHTTFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNINMIVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVIA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu-A, EF-Tu-A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATGT_PYRAB
Sequence: MSRGDKMLKFEVKARDGAGRIGKLEVNGKKIETPAIMPVVNPKQLIVEPKELEKMGFDIIITNSYIIYKDRELREKALEVGIHKLLGYDGIIEVDSGSFQLMRYGNVDVSNREIVEFQHRIGVDIGTFLDIPTPPDAPKEKAMEDLKITLERAREAEEIKEIAMNAAIQGSTYTDLRRYAARRLSSMNFEIHPIGGVVPLLEAYRFREVVDIVISSKMALRPDRPVHLFGAGHPMVFALAVAMGVDLFDSASYALYAKDDRYLTPEGTKRLDELEYFPCSCPVCSRYTPQELREMPKEERARLLAIHNLWVIKEEIERIKQAIREGELWRLVDERARSHPKLYSAYKRLLDHYTFLEEFEPVTKKSAVFKISHESLRWPLVRRARERAERVNSKFGDLVEHPIFGKVTKYLTLTYPFAQSEAEDEFSIEKPTRENAIRYVMAIAEYQFGENASKAFEGAEVELARTGMPRQVKLNGKRLATVRAEDGFLTLGIEGAKRLHKVLEYPRMRVVVSEEAEPFARKGKDVFAKFVLFADPGIRPYDEVLVVNEKDELLATGQALMSGREMIVFQYGRAVKVRRGISGG
What is the function of this protein?
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
What are the official names of this protein?
tRNA-guanine(15) transglycosylase, 7-cyano-7-deazaguanine tRNA-ribosyltransferase, Archaeal tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the archaeosine tRNA-ribosyltransferase family.
Protein: RS9_NEIG1
Sequence: MNGKYYYGTGRRKSSVARVFLTKGTGQIIVNGRPVDEFFARETSRMVVRQPLVLTENAESLDIKVNVVGGGETGQSGAIRHGITRALIDFDAALKPALSQAGFVTRDAREVERKKPGLRKARRAKQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RL27_CHLAB
Sequence: MAHKKGQGASRNGRDSESKRLGMKVGAGQRVSTGSILVRQRGTKWHPSKNVGRGRDDTLFALIDGIVVTRKTDRTYISVLPE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: H2A_BUFGR
Sequence: AGRGKQGGKVRAKAKTRSSRAGLQFPVGRVHRLLRKGNY
What is the function of this protein?
Buforins are strong antimicrobial activities in vitro against a broad-spectrum of microorganisms including fungi.  Buforin II is more potent than buforin I.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: BBS4_HUMAN
Sequence: MAEERVATRTQFPVSTESQKPRQKKAPEFPILEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQQPLGSNQALGQAMSSAAAYRTLPSGAGGTSQFTKPPSLPLEPEPAVESSPTETSEQIREK
What is the function of this protein?
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  Required for proper BBSome complex assembly and its ciliary localization.  Required for microtubule anchoring at the centrosome but not for microtubule nucleation.  May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.
What are the official names of this protein?
Bardet-Biedl syndrome 4 protein.
What is the protein family that this protein belongs to?
Belongs to the BBS4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium, flagellum. Cell projection, cilium. Note=Localizes to the pericentriolar material. Centrosomal localization requires dynein (By similarity). Localizes to the connecting cilium of photoreceptor cells (By similarity).
Protein: Y5284_PSEPK
Sequence: MNIREWPAEERPREKLLQRGAGSLTDTELLAVFLGSGVRGCNVVELSRGLLVKFGSLRRLLEADREAFVGELGLGPVRYSQLQALLEIGRRHLATSIERESAMDSPAAVRRYLKAMLRHEASEVFGCLFLDTKHRPLAFEILFRGTIDRASVYPREVVRRALVHNAAALILCHNHPSGISEPSQDDVHLTLSLKRGLALIDVRVLDHIIIGDGEPLSMVEHGWIVV
What are the official names of this protein?
UPF0758 protein PP_5284.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.