PharMolix/UniProtQA huggingface dataset:
Protein: PMIP_YEAS7
Sequence: MLRTIILKAGSNASIPSLSRQNKLLRFFATAGAVSRTSPGSIKKIFDDNSYWRNINGQDANNSKISQYLFKKNKTGLFKNPYLTSPDGLRKFSQVSLQQAQELLDKMRNDFSESGKLTYIMNLDRLSDTLCRVIDLCEFIRSTHPDDAFVRAAQDCHEQMFEFMNVLNTDVSLCNMLKSVLNNPEVSSKLSAEELKVGKILLDDFEKSGIYMNPDVREKFIQLSQEISLVGQEFINHTDYPGSNSVKIPCKDLDNSKVSTFLLKQLNKDVKGQNYKVPTFGYAAYALLKSCENEMVRKKLWTALHSCSDKQVKRLSHLIKLRAILANLMHKTSYAEYQLEGKMAKNPKDVQDFILTLMNNTIEKTANELKFIAELKAKDLKKPLTTNTDEILKLVRPWDRDYYTGKYFQLNPSNSPSAKEISYYFTLGNVIQGLSDLFQQIYGIRLEPAITDEGETWSPDVRRLNVISEEEGIIGIIYCDLFERNGKTSNPAHFTVCCSRQIYPSETDFSTIQVGENPDGTYFQLPVISLVCNFSPILIASKKSLCFLQLSEVETLFHEMGHAMHSMLGRTHMQNISGTRCATDFVELPSILMEHFAKDIRILTKIGKHYGTGETIQADMLQRFMKSTNFLQNCETYSQAKMAMLDQSFHDEKIISDIDNFDVVENYQALERRLKVLVDDQSNWCGRFGHLFGYGATYYSYLFDRTIASKIWYALFEDDPYSRKNGDKFKKHLLKWGGLKDPWKCIADVLECPMLEKGGSDAMEFIAQSHKS
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.  While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.  Cleaves precursor proteins of respiratory components, including subunits of the electron transport chain and tricarboxylic acid cycle enzymes, and components of the mitochondrial genetic machinery, including ribosomal proteins, translation factors, and proteins required for mitochondrial DNA metabolism.
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP, Octapeptidyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: YJGA_SALDC
Sequence: MTKQPEDWLDDVPGDDIEDEDDEIIWVSKSEIKRDAEELKRLGAELVDLGKNALDKIPLDADLRDAIELAQRIKMEGRRRQLQLIGKMLRQRDVEPIRQALDKLKNRHNQQVVLFHKLEHLRDRLIVEGDDAVAEVLTLWPHADRQQLRSLIRNAKKEKEGNKPPKSARQIFQYLRELAENEG
What are the official names of this protein?
UPF0307 protein YjgA.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: SUCC_MYCSJ
Sequence: MDLFEYQAKELFAKHNVPTTPGRVTDTAEDAKAIAEEIGKPVMVKAQVKVGGRGKAGGVKYAATADDAFTHAQNILGLDIKGHVVKKLLVAEASDIAEEYYISFLLDRANRTYLAMCSVEGGVEIEEVAATKPDRLARIPVDATKGVDEAFAREIAEKGHLPAEVLDAAAVTIAKLWEVFVGEDATLVEVNPLVRTPDDQILALDGKVTLDANADFRHPEHAEFEDRDATDPLELKAKENDLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHNGVKPANFLDIGGGASAEVMANGLDVILNDSQVKSVFVNVFGGITACDAVANGIVKALEILGEEANKPLVVRLDGNRVEEGRKILADANHPLVVLAQTMDEGADKAAELANK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: ISPG_CAMJ8
Sequence: MEYKRFKTRQIKVGNVSIGGDAPISVQSMLFTKTRDIEGSLEQISRLYFAGANIVRLACLDMADARALKEIKAKSPLPLIVDIHFNHNLAVYCAEFIDGVRINPGNIGSKENIKEVVKACKERGIPIRIGVNHGSIEKQFSDKFGYGVDAMLESAMYNIKLLEDLDFFDIKISMKTSDAQKTIEAYERLRPLCDYPFHLGVTEAGTKFHSTVKSSIALGNLLLKGIGDTMRVSMTGELEEEIRVARAILQDSGVQKSGVNIISCPTCGRIQSDLLSAIKIVEEKTKHIKEPLNISVMGCVVNALGEAKGADVAIAFGKNQGLVIRHGEVVAKLKESELVDRFLAEVEDEVKSRAVKE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: THII_STRE4
Sequence: MKYSEIMVRHGELSTKGKNRMRFINRLKANIQDVLSAYSEVTVRSTRDRTHVLLNGADDRSVIEALKPVFGIQGLSPVYKVEKSVPVLIAAVQEIMSSLYREGLTFKISSKRSDHQFELDSRDLNHTLGAAVFEALPHIKAQMKNPDVTLKVEIRDEAAYLSHEDIKGAGGLPVGASGKGMLMLSGGIDSPVAGYLSLKRGVEIEAVHFASPPYTSPGALRKAKDLTQRLTRFGGNIQFIEVPFTEIQEEIKHKAPEAYLMTLTRRFMLRITDAIREKRKALVIINGESLGQVASQTLESMQAINAVTSTPIIRPVVAMDKLEIIDIAQQIDTFDISIQPFEDCCTIFAPDRPKTNPKLANVERYESRFDVDGLVERAVAGIRVTEITPEIETDSLSTLIEELL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICAB_STAAW
Sequence: MKYRKFIILVLSILIILPVSTLDGHHIANADDDSPKKLKYKENSALALNYHRVRKANFLNNFIYFFSSSKEIKNYSVSQSQFESQIKWLKSHDAKFLTLKEFLYYKKKGKFPKRSVWINFDDMDETIYENAYPILKKYKIPATGFIITGHVGEENFHNLDMISKKELKEMYKTGLWEFETHTHDLHNLSKNNKSKLMKASEATIIKDLNKSEKYLTKNFKKSQKTIAYPYGLMNDDKLPVIKKAGLKYGFSLEEKAVTPNSNDYYIPRILISDDAFEHLIKRWDGFHEKD
What is the function of this protein?
Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide.  N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions (By similarity).
What are the official names of this protein?
Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase, PNAG N-deacetylase, Poly-beta-1,6-GlcNAc N-deacetylase, Biofilm polysaccharide intercellular adhesin deacetylase, Biofilm PIA deacetylase, Intercellular adhesion protein B.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Attached to the cell surface.
Protein: MYOTI_HUMAN
Sequence: MFNYERPKHFIQSQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSSHITMSSSAFPASPKQHAGSNPGQRVTTTYNQSPASFLSSILPSQPDYNSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPEGEFQRLAAQSGLYESEEL
What is the function of this protein?
Component of a complex of multiple actin cross-linking proteins.  Involved in the control of myofibril assembly and stability at the Z lines in muscle cells.
What are the official names of this protein?
Myotilin, 57 kDa cytoskeletal protein, Myofibrillar titin-like Ig domains protein, Titin immunoglobulin domain protein.
What is the protein family that this protein belongs to?
Belongs to the myotilin/palladin family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Sarcomeric, also localized to the sarcolemma (PubMed:10369880). Colocalizes with MYOZ1 at the Z-lines in skeletal muscle (PubMed:16076904).
Protein: TU61_LOPOL
Sequence: MRFHWIPTLTVLLVLSMSFGTEAIPXXXXXXXXXXXXXXXXXXXXXXXSEVLECYFECGNWEGTCCDTGICVGIHNCKIPEN
What is the function of this protein?
Acts as a neurotoxin by inhibiting an ion channel.
What are the official names of this protein?
Turripeptide Lol6.1, OL38.
What are the subcellular locations of this protein?
Secreted.
Protein: UL92_EBVB9
Sequence: MSDQGRLSLPRGEGGTDEPNPRHLCSYSKLEFHLPLPESMASVFACWGCGEYHVCDGSSECTLIETHEGVVCALTGNYMGPHFQPALRPWTEIRQDTQDQRDKWEPEQVQGLVKTVVNHLYHYFLNENVISGVSEALFDQEGALRPHIPALVSFVFPCCLMLFRGASSEKVVDVVLSLYIHVIISIYSQKTVYGALLFKSTRNKRYDAVAKRMRELWMSTLTTKC
What is the function of this protein?
Part of the viral pre-initiation complex (vPIC) that is responsible for the expression of vPIC-dependent late genes (PubMed:25165108, PubMed:26202235).  vPIC is composed of at least BcRF1 that binds the viral TATT box, BDLF3. 5, BDLF4, BFRF2, BGLF3, BGLF4 and BVLF1 (PubMed:25165108).
What are the official names of this protein?
Late gene expression regulator BDLF4.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL92 family.
Protein: RL10_SYNS9
Sequence: MGRTLENKQQIVGELKGLLAETELALVLDFKGLSIKEMSDLRDRLRVTNSVCKVTKNTLMRRAIDGDSSWANLDSLLTGTNAFVLVKGDVGAGVKAVRSFQNEFKKSETKGALFEGKLLSQDEIKAIADLPSREELMAQIAGAINAVATKVAVGINEVPTGMARALKQHAEGGDS
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: ACPS_EDWI9
Sequence: MAILGLGTDIVEIARIAAVVERSGDQLARRVLAPAEWQQYLTHAQRVRYLAKRFAVKEAAAKALGTGIRQGLAFAQFEVANDTLGKPRLILHGRAAELAADLGIASLHVSLADERRYACATVIAEG
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSMT2_PETHY
Sequence: MEVVEVLHMNGGNGDSSYANNSLVQQKVILMTKPITEQAMIDLYSSLFPETLCIADLGCSLGANTFLVVSQLVKIVEKERKKHGFKSPEFYFHFNDLPGNDFNTLFQSLGAFQEDLRKHIGESFGPCFFSGVPGSFYTRLFPSKSLHFVYSSYSLMWLSQVPNGIENNKGNIYMARTSPLSVIKAYYKQYEIDFSNFLKYRSEELMKGGKMVLTLLGRESEDPTSKECCYIWELLAMALNKLVEEGLIKEEKVDAFNIPQYTPSPAEVKYIVEKEGSFTINRLETSRVHWNASNNEKNGGYNVSRCMRAVAEPLLVSHFDKELMDLVFHKYEEIISDCMSKEKTEFINVIVSLTKIN
What is the function of this protein?
Converts benzoic acid into the volatile ester methyl benzoates (PubMed:14630969).  This scent, mostly produced in a rhythmical, diurnal manner, attracts the pollinators (PubMed:14630969).
What are the official names of this protein?
S-adenosyl-L-methionine:benzoic acid/salicylic acid carboxyl methyltransferase 2, PhBSMT2.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
Protein: TBB3_BOVIN
Sequence: MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDEEESEAQGPK
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569).  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).  TUBB3 plays a critical role in proper axon guidance and maintenance (By similarity).  Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity).  Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity).
What are the official names of this protein?
Tubulin beta-3 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, growth cone. Cell projection, lamellipodium. Cell projection, filopodium.
Protein: GCH3_SULIY
Sequence: MKVLAIKLVDYREWTERLGYDREWLIQKIQNKFMMKIHEIASQYSTFPLQLRFDNFLMIVDGITNTQLIYMINDMQENLPVGIKTCLGYGKTPLEAQWNASVCLNNKEDKFKEYVDEKIAALHFDINFNTEALKYTSLYDSFLEITNIYVDLSRFLYKIGGILQYLGGDNYLGFVSTNSVNKVIEKFSDDNKIKVGIGIGQNARTAIKLATTSLEKIRNNREKTWHIEEEYH
What is the function of this protein?
Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP.  Also has an independent pyrophosphate phosphohydrolase activity.
What are the official names of this protein?
GTP cyclohydrolase III.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type GTP cyclohydrolase family.
Protein: RSGA_STRP8
Sequence: MQGKIIKSLAGFYYVESEGQVYQTRARGNFRKRGETPYVGDIVDFSAEDNSEGYILAIHPRKNSLVRPPIVNIDQAVVIMSAKEPEFNSNLLDRFLILLEHKAIHPVVYISKMDLLDSPEEIKAIGRQYQAIGYNFVTSLEELLPLLADKITVFMGQTGVGKSTLLNRIAPELALETGEISDSLGRGRHTTRAVSFYNTHGGKIADTPGFSSLDYDIANAEDLNEAFPELRRLSHKCKFRSCTHTHEPKCAVKAALETGELWPVRYEHYLQFLSEIENRRETYKKVIKRK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLAB1_HALSA
Sequence: MFEFITDEDERGQVGIGTLIVFIAMVLVAAIAAGVLINTAGYLQSKGSATGEEASAQVSNRINIVSAYGNVNNEKVDYVNLTVRQAAGADNINLTKSTIQWIGPDRATTLTYSSNSPSSLGENFTTESIKGSSADVLVDQSDRIKVIMYASGVSSNLGAGDEVQLTVTTQYGSKTTYWAQVPESLKDKNAVTL
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
What are the official names of this protein?
Flagellin B1.
What is the protein family that this protein belongs to?
Belongs to the archaeal flagellin family.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: RBSD_GEOTN
Sequence: MKKNGILNKELNTLLASLGHTDTIVIADCGLPIPNEEARIDLALVKGFPPFLSVLDAVINELVVEEIVLAEEIKTQNPDVYESIKARMSDVPIQFVRHEEFKEMTKQAKAVIRTGEATPYANIILRSGVNFS
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHAT_SALDC
Sequence: MSNAITMGIFWHLIGAASAACFYAPFKQVKQWSWETMWSVGGIVSWLILPWAISALLLPDFWAYYGQFNLSTLLPVFLFGAMWGIGNINYGLTMRYLGMSMGIGIAIGITLIVGTLMTPIINGNFDVLIHTEGGRMTLLGVFVALIGVGIVTRAGQLKERKMGIKAEEFNLKKGLLLAVMCGIFSAGMSFAMNAAKPMHEAAAALGVDPLYVALPSYVVIMGGGALVNLGFCFIRLAKVQNLSIKADFSLARPLIISNILLSALGGLMWYLQFFFYAWGHARIPAQYDYMSWMLHMSFYVLCGGLVGLVLKEWKNAGRRPVAVLSLGCVVIIIAANIVGLGMAS
What is the function of this protein?
Uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).
What are the official names of this protein?
L-rhamnose-proton symporter, L-rhamnose-H(+) transport protein.
What is the protein family that this protein belongs to?
Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: A4_DROME
Sequence: MCAALRRNLLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCLGPFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTAQPTSDPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKDLSDTEYGEATVSSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQNVTTHHPIVREEKIVPNMQINGYENPTYKYFEVKE
What is the function of this protein?
During development, plays a role in the regulation of the neddylation pathway.  Appl and APP-BP1 interact antagonistically during development.
What are the official names of this protein?
Amyloid-beta-like protein.
What is the protein family that this protein belongs to?
Belongs to the APP family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CABYR_MOUSE
Sequence: MISSKPRLVVPYGLKTLLEGVSRAILKTNPTNITQFAAVYFKELIVFREGNSSLDIKDLIKQFHQMKVEKWAEGVTVEKKECIKEPIKPPPVPCKPTHMEKSTDTEEDNVAGPLFSNKTTQFPSVHAEVQSEETSEGARGPSDKPTTPKTDYTPPSSPPPAPVSAEYAYVPADPAQFAAQMLGNVPSTYSEVLMVDVATSTPAVPQDVLSAEFAEEVVLSAPLVCSGETVEVQVVSKTSAQVVVGPVSEAEPPKASSAPLQGEQEPPAHEAPDTQVTSASRISSIYNDVPVNEGVVYVEEIPGYIVIPFTDHDQVACVKEIEQSPPGSPKAVEPKTKISIESLKTVQVEENSQHKSSVHVEAEATVLLSNTALDGQPEVPAEPLDAEGFFKVASENSLHLETEIVIINPDDPGQEESGGNAAPHSSGDPFPPAPGGLTEPEMQPDGEAAPEQV
What is the function of this protein?
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.  May bind calcium in vitro (By similarity).
What are the official names of this protein?
Calcium-binding tyrosine phosphorylation-regulated protein, Calcium-binding protein 86, Testis-specific calcium-binding protein CBP86.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localizes to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.
Protein: PAE9_ARATH
Sequence: MKTTTRLLDLTAAMVLVVYVSFSPPLVSGEPGRRVSMTLVRDAAALGAFCLDGSLPAYHLDRGFGAGSNNWILQFEGGGWCNDIASCVERAKTRRGSTRYMSKTVVFTGVLSNNASQNPDFYNWNKVRLRYCDGASFAGDSQFGNGTSLLYFRGQRIWNAIILDLLPKGLAKAHKALLTGCSAGGLSTFLHCDNFTSYLPKNASVKCMSDAGFFLDAIDVAANRTMRSFYSQLVSLQGIQKNLDPSCTHAFFPEPSLCFFPQYVLRFIKTPFFILNSAYDVFQFHHGLVPPSADQTGRWNRCKLNVTACNPHQLDALQGFRKDMLGALMNFFRNSTRGGMFINSCFDHCQSALEETWLSPTSPRINNKTIAETVGDWYFGRGEEAKEIGCPYPCDKTCHNLIPASTSDFLASNASGSGHNSRGTHLTFLFLLLNFFFFFVISKFSKKDYVT
What is the function of this protein?
Hydrolyzes acetyl esters in homogalacturonan regions of pectin.  In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions.  Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
What are the official names of this protein?
Pectin acetylesterase 9.
What is the protein family that this protein belongs to?
Belongs to the pectinacetylesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: MMP2_BOVIN
Sequence: MTEARVSRGALAALLRALCALGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELRTLGEGQVVRVKYGNADGEYCKFPFRFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKEYGFCPETAMSTVGGNSEGAPCVLPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPGVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
What is the function of this protein?
PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin.  Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity).
What are the official names of this protein?
72 kDa type IV collagenase, 72 kDa gelatinase, Matrix metalloproteinase-2, MMP-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity).
Protein: HUTI_FUSNN
Sequence: MQADLVLYNIGQLVTSRELDKTKKMDNIEVIENNGYIVIEKDKIVAVGSGEVLKEYLTPATEMVDLSGKLVTPGLIDSHTHLVHGGSRENEFAMKIAGVPYLEILEKGGGILSTLKSTRNASEQELIEKTLKSLRHMLELGVTTVEAKSGYGLNLEDELKQLEVTKILGYLQPVTLVSTFMAAHATPPEYKDNKEGYVQEVIKMLPIVKERNLAEFCDIFCEDKVFSVDESRRILTVAKELGYKLKIHADEIVSLGGVELAAELGATSAEHLMKITDSGINALANSNVIADLLPATSFNLMEHYAPARKMIEAGIQIALSTDYNPGSCPSENLQFVMQIGAAHLKMTPKEVFKSVTINAAKAIDKQDTIGSIEVGKKADITVFDAPSMAYFLYHFGINHTDSVYKNGKLVFKK
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.