PharMolix/UniProtQA huggingface dataset:
Protein: DDC_HAEIN
Sequence: MSNLKQHKQALFCNDNEAINDYETAMHNAVQAVSAWLKNEKMYTGGSIKQMRALISGFNPTKEGMGVQKSLDHLVEIFLNPSLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSIMEEHLINWLRQKAGYGEGTSGVFTSGGTQSNLMGVLLARDWAIANHWKNEDGSEWSVQRDGIPAEAMQKVKVICSENAHFSVQKNMAMMGMGFQSVVTVPSNANAQMDLIALKQTLAQLKADGKITACIVATAGTTDAGAIDDLKAIRKLADEYQAWLHVDAAWGGALLLSKDYRYFLDGIELTDSITLDFHKHFFQTISCGAFLLKDPENYRFIDYKADYLNSEYDEAHGVPNLVAKSLQTTRRFDALKLWFTLEALGEDLYASMIDHGVKLTKEVEQYINDTPDLEMLVPSQFASVLFRVVPKDYPAEFIDALNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATLENVKALLTQVLTEANRIKDDIKNGTYTPPID
What are the official names of this protein?
L-2,4-diaminobutyrate decarboxylase, DABA decarboxylase, DABA-DC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: EX7S_LEPIN
Sequence: MVETKSKISFEDALMELEQIAEKLERQDFSLEESLKAYERGMELKKICQGILDTAEGKIEALTKDESKKTNKTGFRGESKTTETKNNTAQEEDLF
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAPC_STRPR
Sequence: MRGGSVFGRCVVVGGAGAVGRMFSHWLVRSGVAVTWLDVAGAGAADGVRVVAGDVRRPGPEAVAALAAADVVVLAVPEPVAWEAVEVLAGVMRPGAVLADTLSVKSRIAGRLREAAPGLQAVGLNPMFAPSLGLQGRPVAAVVVTDGPGVRALVELVAGWGARVVEMPARRHDELTAAQQAATHAAVLAFGLGLGELSVDVGALRDSAPPPHLAMLALLARIAGGTPEVYFDIQAANPGAPAARQALGRGLVRLGQAVERGDEETFAALFAELRGVLGEHGAELERLCARMFTALH
What is the function of this protein?
Involved in pristinamycin I biosynthesis (PubMed:9044253).  Probably catalyzes the formation of 3-(4-aminophenyl)pyruvate from 4-amino-4-deoxyprephenate (Probable).
What are the official names of this protein?
4-amino-4-deoxyprephenate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the prephenate/arogenate dehydrogenase family.
Protein: QUEA_STRMU
Sequence: MNTSDFDFNLPEALIAQTPLKKRDSSKLLVVDHQKKTMKDTHFDHIIDELNSGDALVMNDTRVLPARLHGEKTVTHGHVELLLLKNIQGDQWEVLAKPAKRLKVGSHISFGDGRLKAIIKEELDHGGRIVEFSYEGIFLEVLESLGEMPLPPYIHEKLEDRDRYQTVYAKENGSAAAPTAGLHFTEELLSKIEAKGVKLVYLTLHVGLGTFRPVSVDNVEEHQMHSEFYSLSPEAAQTLKDVKANGGRIVAVGTTSIRTLETIGNKFAGQIEADSGWTNIFIKPGYQFKIVDAFSTNFHLPKSTLVMLVSAFAGRDFILDAYKHAVDKHYRFFSFGDAMFVK
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_RALSO
Sequence: MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLEANEYGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSNIDVNVSIGTIFSVLHMPKPGQTVTEADFMQPGVRQVAAGYAVYGPQTTLVLTVGNGVHMFTLDREVGSFILTNRDVKIPADTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNMRWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGHQRILEIQPEKLHQRVAVILGSKNEVDRVTQYHREAQQTA
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIRC_ORYSJ
Sequence: MVFFPEEVVEHILGFLASHRDRNAVSLVCREWYRVERLSRRSVLVRNCYAARPERVHARFPGLRSLSVKGRPRFVPAGWGAAARPWVAACVAACPGLEELRLKRMVVTDGCLKLLACSFPNLKSLVLVGCQGFSTDGLATVATNCRFMKELDLQESLVEDRDSRWLGCFPKPSTLLESLNFSCLTGEVNSPALEILVARSPNLRSLRLNRSVPLDVLARILCRRPRLVDLCTGSFVRGNIVGAYAGLFNSFQHCSLLKSLSGFWDATSLFIPVIAPVCKNLTCLNLSSAPMVRSAYLIEFICQCKKLQQLWVLDHIGDEGLKIVASSCIQLQELRVFPANANARASTVTEEGLVAISAGCNKLQSVLYFCQRMTNSALITVAKNCPRFTSFRLCVLDPGSADAVTGQPLDEGYGAIVQSCKGLRRLCLSGLLTDTVFLYIGMYAERLEMLSVAFAGDTDDGMTYVLNGCKNLKKLEIRDSPFGDSALLAGMHQYEAMRSLWLSSCNVTLGGCKSLAASMANLNIEVMNRAASINEADNANDAKKVKKLYIYRTVAGPRGDAPEFISTF
What are the official names of this protein?
Transport inhibitor response 1-like protein Os11g0515500, TIR1-like protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: LPXC_CUPPJ
Sequence: MLKQRTIKSLVKTVGIGLHSGRKVTLTLRPAPADTGIVFTRVDLPEAVEIPAAAGAIGDTRLASVLQKDGARVSTVEHLMSACAGLGIDNLYVDVDAEEIPIMDGSAASFVFLLQSAGIEQQNAAKRFIRVKKAVEVREGDKLARLEPFFGFKLSFTIDFRHPAVDKTGQNFEIDFADTSYVREIARARTFGFAHEVEALREMGLARGGSLDNAIVLDEHRMLNNEELRYGDEFVRHKILDAIGDLYVVGHPLIGAYVAHKSGHGLNNQLLRALLADQEAYEVVTFDRMEDAPVAFLPQVQPAFA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: OAR2_LYMST
Sequence: MMSFPIALFADVNQSFRANLVVSSYHHAITFPTVRGANFSTFFPRNFSVSADVWLCGANFSQEWQLMQPVCSTKYDSITIFITVAVVLTLITLWTILGNFFVLMALYRYGTLRTMSNCLIGNLAISDLLLAVTVLPISTVHDLLGYWVFGEFTCTLWLCMDVLYCTASIWGLCTVAFDRYLATVYPVWYHDQRSVRKAVGCIVFVWIFSIVISFAPFIGWQHMIPSFFSFNASIQRYQCILFTSSSYVLYSSMGSFVIPAILMAFMYVRIFVVLHNQSRGVKFKSGLKISSSKYNGCPVINEPSREGINGLGRDVTNTTLLSDAVGSSADLTSNGKDDPRVLATAPIELTEDVPPLNGHHHRTVHETPYVSGLHTKRSNSFALPTELEKKCKPLTNNILHMMDFDRRNSHNAVIQRSASEMVNLDVSKHELLISNVCHRSKSATALTSETGDPLGSLAGPRRSLQCNVGGLVRNKHMTLSMKRRFELREQRATKRMLLIMACFCVCWMPFLFMYILRSVCDTCHMNQHFVAAIIWLGYVNSSLNPVLYTLFNDDFKVAFKRLIGARSPSAYRSPGPRR
What is the function of this protein?
Receptor for octopamine.  Octopamine (OA) is a neurotransmitter, neurohormone, and neuromodulator in invertebrates.  This receptor induces a long lasting opening of voltage- independent chloride channels, a process which seems to involve protein phosphorylation but does not require either cAPK or PKC.  The rank order of potency for agonists is p-synephrine > p-octopamine > xylometazoline > B-HT920 > norepinephrine = clonidine > epinephrine > p-tyramine > phenylephrine = oxymetazoline = mehoxamine = dopamine > serotonin > histamine.  For antagonists, the rank order is rauwolscine = mianserin > phentolamine > chlorpromazine > spiperone > yohimbine > propanolol > alprenolol > prazosine > pindolol.
What are the official names of this protein?
Octopamine receptor 2, OA2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2690_YERPB
Sequence: MTIKPSDSVSWFQVLQRGQHYMKTWPADKRLAPVFPENRVTVVTRFGIRFMPPLAIFTLTWQIALGGQLGPAIATALFACGLPLQGLWWLGKRAITPLPPTLLQWFHEVRHKLSEAGQAVAPIEPIPTYQSLADLLKRAFKQLDKTFLDDL
What are the official names of this protein?
UPF0208 membrane protein YPTS_2690.
What is the protein family that this protein belongs to?
Belongs to the UPF0208 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PUS7_HUMAN
Sequence: MEMTEMTGVSLKRGALVVEDNDSGVPVEETKKQKLSECSLTKGQDGLQNDFLSISEDVPRPPDTVSTGKGGKNSEAQLEDEEEEEEDGLSEECEEEESESFADMMKHGLTEADVGITKFVSSHQGFSGILKERYSDFVVHEIGKDGRISHLNDLSIPVDEEDPSEDIFTVLTAEEKQRLEELQLFKNKETSVAIEVIEDTKEKRTIIHQAIKSLFPGLETKTEDREGKKYIVAYHAAGKKALANPRKHSWPKSRGSYCHFVLYKENKDTMDAINVLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKITAQRLAHLNKCLMNFKLGNFSYQKNPLKLGELQGNHFTVVLRNITGTDDQVQQAMNSLKEIGFINYYGMQRFGTTAVPTYQVGRAILQNSWTEVMDLILKPRSGAEKGYLVKCREEWAKTKDPTAALRKLPVKRCVEGQLLRGLSKYGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNNMVSKRIEDYGLKPVPGDLVLKGATATYIEEDDVNNYSIHDVVMPLPGFDVIYPKHKIQEAYREMLTADNLDIDNMRHKIRDYSLSGAYRKIIIRPQNVSWEVVAYDDPKIPLFNTDVDNLEGKTPPVFASEGKYRALKMDFSLPPSTYATMAIREVLKMDTSIKNQTQLNTTWLR
What is the function of this protein?
Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:35051350, PubMed:34718722).  Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141).  Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350).  Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350).  Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350).  In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141).
What are the official names of this protein?
Pseudouridylate synthase 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VKTR1_CYRHA
Sequence: MGIARILSAVLFLSVLFVVTFPTLLSADHHDGRTDTCRLPSDRGRCKASFERWYFNGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA
What is the function of this protein?
Serine protease inhibitor that inhibits trypsin and blocks voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type U15-theraphotoxin-Hhn1r, U15-TRTX-Hhn1r, Kunitz-type serine protease inhibitor hainantoxin-XI-18, HNTX-XI-18.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 01 (intermediate) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KDGD_BRADU
Sequence: MSKMTPQEMAQTIGSGLLSFPVTPFKADYSFDEATYRANMDWLCGYDVAGLFAAGGTGEFFSLTPTEVPQIVKIAVEETKGRVPVLAGTGYGTAIAREIAVGAEKAGADGLLLLPPYLTHSEQDGLAAHVEAVCAAVKIGVIVYNRDNAILQPDTLARLAERCPNLVGYKDGIGDIELMTRVYTKLGDRLTYIGGLPTAETFALPYLDMGVTTYSSAVFNFVPEFATNFYAAVRKRDHATIHAGLKDFILPLIAIRNRKKGYAVSIIKAGMKVIGRDSGPVRPPLTDLTEQEIAELTALVKKLPAIRSSQQAAE
What are the official names of this protein?
Probable 5-dehydro-4-deoxyglucarate dehydratase, 5-keto-4-deoxy-glucarate dehydratase, KDGDH.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
Protein: TYB10_HUMAN
Sequence: MADKPDMGEIASFDKAKLKKTETQEKNTLPTKETIEQEKRSEIS
What is the function of this protein?
Plays an important role in the organization of the cytoskeleton.  Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
What are the official names of this protein?
Thymosin beta-10.
What is the protein family that this protein belongs to?
Belongs to the thymosin beta family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SUCC_ALTMD
Sequence: MNLHEYQGKQLFKEYGLPVSEGYAADTAQGAVEAADRIGGEEWVVKCQVHAGGRGKAGGVKLVKNKDDIRAFAENWLGKNLVTFQTDENGQPVSKILVESCTDIANELYLGAVVDRTTRRVVFMASTEGGVEIETVAEETPEKILKAEIDPIVGPQPYQAREMAFALGLSGVQIKQFTQIFLGLAKMFEELDVALIEINPLVIKTDGNLHCLDAKVGIDGNALYRQPKLKDMQDPSQEDAREAHAAQWELNYVALDGNVGCMVNGAGLAMGTMDIVNLHGGKPANFLDVGGGATKERVAEAFKIILSDDNVKAVLVNIFGGIVRCDMIAEGIIGAVKEVGVEVPVVVRLEGTNAELGREVLANSGLDIIAAESLTDAAQKVVAAAEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: NTRB_RHIME
Sequence: MTEKATAPGEGANDLSMAVLNAIQNPVILVDENGFVAFANWEAESFFGASANHLARHDISAFIPFGSPLLTLIEQVRERRAAVNEYRVDLSSPRLGADKLVDLYVAPVLSQPGSVVIVFQERSMADKIDRQLTHRAAARSVTGLASMLAHEIKNPLSGIRGAAQLLETSVNDEDRSLTRLICDETDRIVSLVDRMEVFSDERPVDRLPLNIHAVLDHVKAIAKAGFARRIKISEHYDPSLPPVFANRDQLVQVFLNLIKNAAEAIGDRADGEILLTTAYRPGIRLSVAGTREKISLPLEFCVHDNGPGVPPDLLPHLFDPFITTKTNGSGLGLALVAKIIGGHGGIVECDSQHSRTTFRVLMPASKGLAADEETPMTKGTNG
What is the function of this protein?
Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation.  Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC.  In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC.
What are the official names of this protein?
Sensory histidine kinase/phosphatase NtrB, Nitrogen regulation protein NR(II), Nitrogen regulator II, NRII.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_HYDS0
Sequence: MNLHELKPNESAVKDKKRIGRGLGSGKGKTAGRGYKGQKSRSGDNRVAPYFEGGQTPLHMRVPKVGFRSPFKKEYSVINLSMLEKHFNDGDEITKETLLAKSLIKKGKPVKILGMGEVTKKFKVKVDAISSSAKQKIEAAGGSVEILEAAGE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: CYC11_CHACT
Sequence: IPCGESCVWIPCISGMFGCSCKDKVCYS
What is the function of this protein?
Chassatide C11A: Probably participates in a plant defense mechanism (Probable).  Has no activity against bacteria up to a concentration of 80 uM (PubMed:22467870).  Has no cytotoxic and no hemolytic activity (PubMed:22467870).
What are the official names of this protein?
Chassatide C11, Cyclotide chaC11.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: UL02_HCMVM
Sequence: MAEDSVTILIVEDDDAYPSFGSLPASHAQYGFRLLRSIFLIMLVIWTAVWLKLLRDALL
What are the official names of this protein?
Uncharacterized protein UL2.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 UL2 protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: RAD3_SCHPO
Sequence: MSQHAKRKAGSLDLSPRGLDDRQAFGQLLKEVLALDKEHELGRSNSLPSMTSELVEVLIEVGLLAFKHDDSKSEFISPKMLKEAHLSLQALMLILKRSPTVLREIKSSVTLLDWILPRTISLFADIRFIKLFDSLKEFHKLIYQLISEKSFLWDLYASFMRYWKYYITNVSSIVLQITNATFPYKMPSPNSQPLQSITPNYPTHREDKFDLLIINIEEACTFFFESAHFFAQCSYLKKSNFPSPPLFTAWTWIKPCFFNFVILLKRISIGDSQLFLHLHSRIVQTLCCFSLNFIYHGLPICEKSKHILMSSINLTLGSLKKTYTVANTAISLFFLSLFVLPKTVAGLFYPFGVSLLSDFKVLEQLEPDSDLKKAIILFKCRYQSSEIDQTTLRAFGEICTGKLENTLFSNSELNLFLLHYLSLDNDLSNILKVDFQNGHNICTFAKWCINNNLDEPSNLKHFREMLDYYSSHNVTISEDDLKNFSLVLCTHVAKVNEKTNSIFRTYEVHGCEVCNSFCLLFDERSLFKIPYHELFCALLKNPDIISSSVKQSLLLDGFFRWSQHCSNFNKESMLSLREFIMKALASTSRCLRVVAAKVLPIFIKGPNNLDIVEFHKESKALIFNTLKILAVENTAILETVILSWISLSRVVEEEELHFVLLEVISSVINSGIFYQGIGLSALQQIASTRHISVWQLLSPYWPTVSVAIVQGMGKKPNIASLFAQLMNISEGDFLIRTQAYTLPFLVLTKNKALIVRIAELSQSDVATLCLTNMHKILASLLTTDHPNLEESVMLLLSLATSDFEKVDLTSLLRSDPISITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTIVGIEKMLSLCGGAVKLGLPQILSNLQSAFQNEHLRFYAIKAWFSLILATKEPEYSSIAGLSLVILPPLFPYLEPQEAELVIQIFDFISSDTHKCLQGLKWAIPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELHDTLNLDISNEVLDQLLRCLLDCCVKYASTNMQISYLAAKNLGELGAIDPSRAKAQHIIKETVVLDNFENGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQEFLKLGGFKSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFLVLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRFPSKTLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGIDDPDEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLDSFIINDNHEYSKMLNLGIEASWRSLSIDSLKKCLSKSNLESFEAKLGSIFYQYLRKDSFAELTERLQPLYVDAATAIANTGAHSAYDCYDILSKLHAINDFSRIAETDGIVSDNLDIVLRRRLSQVAPYGKFKHQILSTHLVGYEKFENTKKTAEIYLEIARISRKNGQFQRAFNAILKAMDLDKPLATIEHAQWWWHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKLLTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYFFLVALSQMISRVCHPNNKVYKILEHIIANVVASYPGETLWQLMATIKSTSQKRSLRGKSILNVLHSRKLSMSSKVDIKALSQSAILITEKLINLCNTRINSKSVKMSLKDHFRLSFDDPVDLVIPAKSFLDITLPAKDANRASHYPFPKTQPTLLKFEDEVDIMNSLQKPRKVYVRGTDGNLYPFLCKPKDDLRKDARLMEFNNLICKILRKDQEANRRNLCIRTYVVIPLNEECGFIEWVNHTRPFREILLKSYRQKNIPISYQEIKVDLDFALRSPNPGDIFEKKILPKFPPVFYEWFVESFPEPNNWVTSRQNYCRTLAVMSIVGYVLGLGDRHGENILFDEFTGEAIHVDFNCLFDKGLTFEKPEKVPFRLTHNMVDAMGPTGYEGGFRKASEITMRLLRSNQDTLMSVLESFLHDPLVEWNRKKSSSKYPNNEANEVLDIIRKKFQGFMPGETIPLSIEGQIQELIKSAVNPKNLVEMYIGWAAYF
What is the function of this protein?
Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses.  Involved in G2 arrest following DNA damage where it phosphorylates chk1 (PubMed:8978690, PubMed:1398093).  Phosphorylation of 'Thr-73' and 'Ser-80' of checkpoint mediator crb2 promotes its interaction with chk1 (PubMed:14739927).  It is also involved in the dependence of mitosis on the completion of DNA replication (PubMed:1398093).
What are the official names of this protein?
Protein kinase rad3, DNA repair protein rad3.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. ATM subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ABHD2_DROME
Sequence: MSTAFLTLIAVIVCILFRILNVHSQPLKPSVWCLDAHFLDCLYKIAPVLREPYIPPRLWGFSGHVQTVLHSIVGRVRCPWPLGERVYMSLKDGSTLTYDLYQPLNEQEDDITVAICPGIANSSESVYIRTFVHLAQCNGYRCAVLNHIGALRSVQVTSTRIFTYGHTEDFAAMVEHLHQKYRQSRIVAVGFSLGGNLVTKYMGEDQKTKPDKVIGGISICQGYNAVEGTKWLLNWQNFRRFYLYIMTENVKSIILRHRHILLSDEVKARHNLNEREIIAAATLPELDEAYTRRVYNFPSTQELYKWSSSLFYFDTIKKPMIFINAKDDPLIPEDLLHPIKEYATTRQNTAYVEVAHGGHLGFYEGGFLYPNPVTWLDRTLVAMVGSLVMMHEVGKVAP
What are the official names of this protein?
Abhydrolase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: FBLK1_ARATH
Sequence: MSKKQRCLMMESLPHEVVECILERLDADPLLRFKAVSKQWKSTIESPFFQRRQFTQRQQSGNPDVLMVSRCADINSEIEALTTLVLGSSSSVKIPTPWEEEEEEDKEYSVSQDSCDGLVCLFDKFKSGFVFNPATRWYHPLPLCQLQQLLIAIGDGFYDLGYRVSRLGFGKDKLTGTYKPVWLYNSIEIGLENATTCEVFDFSTNAWRYVSPAAPYRIVGCPAPVCVDGSLHWFTECEETKILSFDLHTETFQVVSKAPFANVDGFDIVMCNLDNRLCVSEMKLPNQVIWSFNSGNKTWHKMCSINLDITSRWFGPTQVCAVLPLALLDGKKKKKKKLLFYCRVRKRTMVVHDDETKSYDVAFEADSIGHPVCYFPSLISIS
What are the official names of this protein?
F-box/LRR-repeat/kelch-repeat protein At1g09650.
Protein: RNPA_LATSS
Sequence: MRKSYRVKKEQDFQTVFDASQSVANRNFVVYRLDKPGQKHFRVGLSVGKKVGNAVMRNQVKRYIRQSITELKPDLLQPVDFLVIARRGANQLTMAETKQNLIHVFKLAKLLKEEADSASE
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: BYE1_SCHPO
Sequence: MVRKSTRRTAKASEKPPETVVRCVCKSQEDIGDTWVQCDGCDCWQHASCVGLADKDIPESYYCEVCHSRSDVSSQVQNSPNKDEEHQTADLLASNEGNEKNNEENNVVSSDSKEAITKESGAELESSEPASTNSNVGMTTRSGRQSPRTPIGSTTPKSSHSPPSTRKRRGSVGTTATHTKRSKNAPKTSPKDASNETADQEKELSLHTSIDEIQNPVRKSVAKAWVSVFEKIIEKAKLEGVQGLEDLNSTSLALQLEHIMFMVLSYTTDHSLTPNNKYREKFRALRFNLVDDKNPAFRARVLKNEISFNDLVNLSSEEMANPDLKNLAEEIRQQSTENTVIKQHLIAPRDRLLDEDKLTQQDELGIAENDDAMFPKPPGELVAPISIAEEEPTIDSKSPTLPEHNPLSEDDTSNGDKAAKRKGSFNDTKPIVNVPSIVEIDDPTILDIVEEEPLARNDSFSSPYSPAEDMAEESEFFGMKEKIWTGKVKMATVSEFHANALNLFGDVSASHLFEILSATALIEGRISVSSVLQYFHALRKTPSKEIIAVLFVPTEQNSQGFDILYDYFVKRNRYGVLHSKSNSVKDAYIIPMPSGNSVPELLDLLPKVDLPKDRNFQYFMGLFVLNKSSSRHESVERATPITTSTNGIPSTYQSASGTPTNPVHSYPSLESIINALTPSDMLLIKDVVENNPQIRANPSLAINPQFMQNAISAAQKKASKQ
What is the function of this protein?
Negative regulator of transcription elongation.
What are the official names of this protein?
Transcription factor bye1.
What is the protein family that this protein belongs to?
Belongs to the BYE1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECQ5_RAT
Sequence: MSARPFSTPFDRERRVRSTLKKVFGFDSFKTPLQESAIMAVVKGDKDVFVCMPTGAGKSLCYQLPAVLAKGITIVVSPLIALIQDQVDHLLALKVQVSSLNSKLSVQERKELLSDLERDKPRTKLLYITPEMAASASFQPTLNSLLSRNLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLAHAPCVALTATATPQVQEDVFAALHLKQPVASFKTPCFRANLFYDVQFKELIPDVYGNLRDFCLKALGQKADNGSSSGCGIVYCRTREACEQLAIELSSRGVNAKAYHAGLKASERTQVQNEWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKELAKLQEKRGNKPSDKATLLAFDALVTFCEEVGCRHAAIAKYFGDAPPACAKGCDCCQSPAAIRKKLDALEHSSSWGKTCIGPSQGDGFDPELYEGGRRGYGGFSRYDEGSGGSGDEGRDEAHKREWNLFYQRQMSLRKGKEAKPEEFTPPGEDCPLRDASSRKIPKLTVKAREHCLRLLEEALNSNHQAAGSTHGADLQAKAVELEHETFRSAKMVNLYKASVLKKVAEIHKASKDGQLYDMESSTKSCGAIAELLEPSDYDIPPTSHLYSLKPKRVGAGFSKGPCPFQTATELLGKSQTEKLAPEAALESEQEPSGWVCDPQDGDRSKPCLGYQEEAPGSRTNCGDPSPEKRTKGSSQGSAKARASKRQQLLATAARKDSQSITRFLRQRTECPPPAASVPSSEDASPCGDVPGKCTEEVGAQGHLVAVFQTECPRERLSTCSLEDQSLPKGQPSPLKETQAEKRPRPQQESQEKRAQKRLRPSTNSSALASDPSTENRVAREPCQLSAPGISLKEAADIVVRYLTPFYKEGRFISKDLFKGFARHLSHLLAQKLSPGRSVKEEAQSLIKQFFHNRARCESEADWHGLCGPQR
What is the function of this protein?
DNA helicase that plays an important role in DNA replication, transcription and repair.  Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability.  Associates also with POLR1A and enforces the stability of ribosomal DNA arrays.  Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress.  Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis.  Required for efficient DNA repair, including repair of inter-strand cross-links.  Stimulates DNA decatenation mediated by TOP2A.  Prevents sister chromatid exchange and homologous recombination.
What are the official names of this protein?
ATP-dependent DNA helicase Q5, DNA helicase, RecQ-like type 5, RecQ5, RecQ protein-like 5.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Note=Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks.
Protein: RL15_JANSC
Sequence: MKLHELSDNPGATKKRKRVGRGPGSGTGKMGGRGIKGQKSRSGVAINAYEGGQMPLYQRLPKRGFNKPNRKKFAVVNLGLIQKFIDAGKLDGKADITEDALVASGLVRRKLDGVRVLAKGDVSGKLNITVTGASKAAIDAVSAAGGALTVSAPAAAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RS20_CAMHC
Sequence: MANHKSAEKRARQTIKRTERNRFYRTRLKNMTRAVKEAVEAKDVDAAKAALKVVNQNFHSFVSKGFLKKETASRHVSRLAKLVNSLVA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.