PharMolix/UniProtQA huggingface dataset:
Protein: CGHE_CHAGB
Sequence: MTKYTSVNSSLPSLPRQTTPTRPATQTGRWDRMGMQTGNTPSSPLGFETKGSLNGSPTLRTTLDTSLSGTRSHPALRATRWMMGVNDIDSIQGDEDHPHDPGPDSDAKKRCASGKAPKDRPTSSVAVASTIRPPCCG
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of the tetramic acid Sch210972, a potential anti-HIV fungal natural product that contains a decalin core (PubMed:26360642).  The PKS module of cghG together with the enoylreductase cghC catalyze the formation of the polyketide unit which is then conjugated to 4-hydroxyl-4-methyl glutamate (HMG) by the condensation domain of the cghG NRPS module (PubMed:26360642).  One unique structural feature of Sch210972 is the tetramic acid motif proposed to be derived from the non-proteinogenic amino acid HMG, by a Dieckmann-type condensation catalyzed by the reductase domain of cghG (PubMed:26360642).  The aldolase cghB catalyzes the aldol condensation of 2 molecules of pyruvic acid to yield the intermediate 4-hydroxyl-4-methyl-2-oxoglutarate (HMOG), which can then be stereoselectively transaminated by an unidentified enzyme to form HMG (PubMed:26360642).  The Diels-Alderase cghA then uses the Dieckmann product released by cghG as substrate and catalyzes the Diels-Alder cycloaddition to form the decalin ring of Sch210972 (PubMed:26360642).  CghA also suppresses the nonenzymatic formation of the alternative stereoisomer (PubMed:26360642).
What are the official names of this protein?
Sch210972 biosynthesis cluster protein E.
Protein: RLME_RHOP2
Sequence: MAKDTTGRMRVTVKSGGRMKLSSKLWLDRQLNDPYVAQAKRDGYRSRAAYKLTEIDDKYHFLKSGQAVVDLGAAPGGWSQVAAKRIGSANGRGKLIAIDLLEMGEIPGVTFAQLDFLDSAAPDKLREMLGGDGADVVMSDMAGNTTGHRKTDQLRIVGLVESAAQFASEVLKPGGIFVAKVFQSGADATLMNQLKRDFATVKHVKPAASRKDSSERYVLAMGFRGTQPAAQEPQEP
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN493_HUMAN
Sequence: MNECNVHKEGYNELNQYLTTTQSKIFQCDKYVKVFHKLLNSNRHNTKHTGKKPFKCKKCGKSFCMLLHLCQHKRIHIRENSYRCEECGKAFIWFSTLTRHRRVHTGEKSYKYECGKSFNQDSNLTTHKRIHTGQKPYKCEECGTSFYQFSYLTRHKLIHTREKPYKCEQYGKTFNQSSTLTGHKIIHNGEKPYKCEECGKAFSIFSTPTKHKIIHTEEKSHRCEEYCKAYKESSHLTTHKRIHTGEKPYKCEECGKAFSIFSTLTKHKIIHTEEKSHRCEECGKAYKESSHLTTHKRIHTGEKPYKCEECGKTFSVFSILTKHKIIHTEEKPYKCEECGKAFKRSSTLTKHRIIHTEEKPYKCEECGKAFNQSSTLSIHKIIHTGEKPYKCEECGKAFKRSSTLTIHKMIHTGEKPYKCEECGKAFNRSSHLTTHKRIHTGHKPYKCKECGKSFSVFSTLTKHKIIHTDKKPYKCEECGKAFNRSSILSIHKKIHTGEKPYKCEECGKAFKRSSHLAGHKQIHSVQKPYKCEECGKAFSIFSTLTKHKIIHTEEKPYKCEKCGKTFYRFSNLNTHKIIHTGEKPCKCEECGKAFNHSSNLIKHKLIHTGDKPYKCEACGKAFRRSSHLSRHKIIHIGIHTEETVQK
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 493.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNMC_LEPBJ
Sequence: MLSWKNDLTPVSDRFDDIYFSPENGLEETRHVFIGGNDLPDRWRNSNIQNPFCILELGFGTGLNFFATWKEYLKQDNRFRLHFISVEKFPLSRKEISKAVSAFPELEEIKEEFLSSYQDLIPGMNYFRFLEGKIHLTLFLGDVSDALCEISGKADAIFLDGFAPSKNPEMWEESVLGNLKNVSKFGTTFSTFTVARTVRNSLSYAGFTLEKRPGFGKKREMLTGKYSNYPSETKESLPKEKPWCKRSDPESQIKTATIIGAGIAGSTLAYSLSKRGIQVFLIDPSGIANETSGIPRAISHPHLTKIPGPISLFTLRAFRYALSFLSSFADKDQFGKVGSFHGVTAEMNPERFRKSIENHKLTEEIASWKPNGSDFHKNDPFNKELEEGVLFRNGFWTRPGSIARKCVDQPGIELIQATANSFERIGSSWKLDLKESDQKVLADSIIFCNSYLIGKLASSLFEGEEIFPINKVRGQLISLKETENSSRVPNILCAEHYLTPSVQGEHVLGSTFDEFDLNPKPRKKDTDLLLQYVQTKYPTLRFDSNCVLSEKTGFRAQTPDRFPIIGPIFDPKIFQETYKEIDLPRNRNKKFPNLKVIPGLYVFGGLGSRGILSSFLGAEILASLILGEPAPVEFSLLESLHPARFLYRRIRK
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSI3_PSEAE
Sequence: MKTVALILASLALLACTAESGVDFDKTLTHPNGLVVERPVGFDARRSAEGFRFDEGGKLRNPRQLEVQRQDAPPPPDLASRRLGDGEARYKVEEDDGGSAGSEYRLWAAKPAGARWIVVSASEQSEDGEPTFALAWALLERARLQ
What is the function of this protein?
Immunity protein that plays a role in preventing early activation of toxin Tse3.  Occupies Tse3 substrate binding site and prevents the substrate from entering.
What are the official names of this protein?
Immune protein Tsi3, Anti-toxin protein Tsi3.
Protein: MAT1_ALTAL
Sequence: MDTAGFVSRLLRNPAEAEVDRFLQTRSGKQMVQLFRLIPEPAAQAALTARLLLLAPQVMSGRHRFVAPEKAKKALNAFVGFRCYYISIPHFKSWPMKKLSNLIGLLWETDPNKSLWSLMTKAWSAIRDQIGKDRAPLDQFFSLICPHLNMPAPESYLAVLGWSVSINEEGDPTISHDGSSRSACVGAGLSDTALSVQDIIAYVQSMGYASTYVADVNTTSPTFLGHSVTSTAEKSNLAGAATPAVAPATDRRITARNKRRAKRELAKVTGLRANLEQDILNAHRVDPGRAGEYMPDHYPTPAAVNYDPIPFYDQLVGYFDSPIPNFQDDAAMSSGATLIDATPVSDDTLHGEMDDIVSNAAFFQSDFDAFRSGANEDATLPTFDDVFNA
What is the function of this protein?
Required for mating.
What are the official names of this protein?
Mating-type protein MAT-1.
What is the protein family that this protein belongs to?
Belongs to the MATALPHA1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FLHF_HELPY
Sequence: MVKFYTYSGETAAEALKIAQSHHGVDTLVFKTQEIRKKTLTSSGLYEIVVAVEEESENKPSKAPLIPESLYDEELNEEDVVMQLSSTVEEMRKLAGVSSSQRHYSFSKNKTLLEKDAPLEDAPLEANKQDALLQALKDEANHKKEREKREVKQEEEIKDINLQLSKIRDSLKLIQNMFWDEKNPNSINIPQEFAEIYKLAKQSGMKPSHLDEIMQLSLELMPLRMRENSVTIKRYFREVLRKMILCCPEDLNLRQKRILMLVGPTGVGKTTTLAKLAARYSRMLAKKYKVGIITLDNYRIGALEQLSWYANKMKMSIEAVIDAKDFAKEIEALEYCDFILVDTTGHSQYDKEKIAGLKEFIDGGYNIDVSLVLSVTTKYEDMKDIYDSFGVLGIDTLIFTKLDESRGLGNLFSLVHESQKPISYLSVGQEVPMDLKVATNEYLVDCMLDGFSNPNKEQA
What is the function of this protein?
Necessary for flagellar biosynthesis.  May be involved in translocation of the flagellum (By similarity).
What are the official names of this protein?
Flagellar biosynthesis protein FlhF, Flagella-associated GTP-binding protein.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TRI17_MOUSE
Sequence: MDAVELARRLQEEATCSICLDYFTDPVMTACGHNFCRECIQMSWEKGKVKKGKKKQKGSFPCPECREMSPQRNLRPNRLLTKVAEMARQHPGLQKRDLCQAHQEPLKLFCQDDQSPICVVCREAQEHRMHRVLPLDEAAREYKLKLEEDIKYLREEMMKTETLQAKEEQTLTEWQERVKERRERILEEFQKVVLFLVEEERRILQVLKKEEEDTLGKLQDSKASLDHQSRSLDLILLQLEERSQQEPLQMLQDVKDTLNRKESFSVQYPEVVLPAAIKTLCRVPGQIEVLKSFQEDVMPDPSSAYPYLLLYESRQRRYLSPPPEGSAPYSKDRFVAYPCAVGQKSFSSGRHYWEVGMNLTGDALWALGVCRDNVSRKDRVLKSPENGFWVVQLSKGKKQLSLLPNSTLVTLTEPPSHMGIFLDFQAGEVSFYSVNDGSHLHSFSQAAFPGPLLPFFCLGAPKSGQMVISTVTMWVKG
What is the function of this protein?
E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation (PubMed:20559321, PubMed:22976837, PubMed:25215946).  Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation.  Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies.  Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (By similarity).  Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death (PubMed:22976837).  In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities (PubMed:25215946).  Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (PubMed:30485814).  Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM17, RING-type E3 ubiquitin transferase TRIM17, Tripartite motif-containing protein 17.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome.
Protein: FLGI2_CHRVO
Sequence: MKKWIVMASLLLAALPAMSAQRLKDIANIGGVRPNQLIGYGLVVGLDGSGDKVTSSPFTGQAMINMLNQLGVQVPPGTKIDPKNVAAVTLTATLPPFSKRGQMLDVTASSIGDAKSLRGGTLLLSPLKGADGQIYAMAQGNVVVGGAGASAGGSSTQINQLSVGRIPSGATVEREVQTALGDGEFIHLELQESDFTTANRAVQAINKVFGGDTARAVDGRLIEVRAPFDSNQRVQFLSRMENIAVDPADLSPLVIINARTGSIVMNQAVTLGSCAVSHGNLSVTVNNTPQVSQPNPLSGGKTVVTNQADITINSTSGKVVGLKGGANLSQVVNALNALGATPQDLISILQAMKSAGSLKADLQII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein 2, Basal body P-ring protein 2.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: GARL_SALPB
Sequence: MNNAIFPNKFKAALAAQQVQIGCWSALASPITTEVLGLAGFDWLVLDGEHAPNDVTTLIPQLMALKGSASAPVVRVPTNEPVIIKRMLDIGFYNFLIPFVETQEEAARAVASTRYPPEGIRGVSVSHRANMFGTVPDYFAQSNKNITIIVQIESQLGVDNVDAIAATEGVDGIFVGPSDLAAALGHLGNASHPDVQQTIQHIFARAKAHGKPCGILAPVEADARRYLEWGATFVAVGSDLGAFRASTQKLADTFKK
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
What are the official names of this protein?
5-keto-4-deoxy-D-glucarate aldolase, KDGluc aldolase, KDGlucA, 2-dehydro-3-deoxy-D-glucarate aldolase, 2-keto-3-deoxy-D-glucarate aldolase, 5-dehydro-4-deoxy-D-glucarate aldolase, Alpha-keto-beta-deoxy-D-glucarate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
Protein: CCNA_PATVU
Sequence: MSMVHGSSFQIAQDGENENQGVQRVKKAGLTARGNVAVAKRSALGTITNQNIRVQPSRAAKSGNADCQDENVFAKQKSFGSSNNENKGFKIHVDEPTVQVLTTATLKTTRQSEDEDIKLNDQVTSLPSLQALEDIQVDNENGSPMVLDVTIEDAEKKPIDREAIILSVPEYAEDIYKHLREAESRHRSKPGYMKKQPDITNSMRSILVDWMVEVSEEYKLHRETLFLAINYIDRFLSQMSVLRGKLQLVGAASMFIASKYEEIYPPEVSEFVYITDDTYEQKQVLRMEHLILKVLSFDVAQPTINWFTDTYAKMADTDETTKSLSMYLSELTLVDADPYLKYLPSTIAAASLCLANITLGSEPWPSSLAKESKYEISEFSECLQEMYQTYLNAPNHPQQAIREKYKSSKYQQVSSISPPSSLSFTM
What is the function of this protein?
Essential for the control of the cell cycle at the G2/M (mitosis) transition.  Interacts with the CDC2 and CDK2 protein kinases to form MPF.  G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
What are the official names of this protein?
G2/mitotic-specific cyclin-A.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
Protein: ARSG_HUMAN
Sequence: MGWLFLKVLLAGVSFSGFLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAPRGRSLYGAGLWEMDSLVGQIKDKVDHTVKENTFLWFTGDNGPWAQKCELAGSVGPFTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLPQGRRFDGVDVSEVLFGRSQPGHRVLFHPNSGAAGEFGALQTVRLERYKAFYITGGARACDGSTGPELQHKFPLIFNLEDDTAEAVPLERGGAEYQAVLPEVRKVLADVLQDIANDNISSADYTQDPSVTPCCNPYQIACRCQAA
What is the function of this protein?
Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate (PubMed:18283100, PubMed:29300381).  Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin (PubMed:22689975).
What are the official names of this protein?
Arylsulfatase G, ASG, N-sulfoglucosamine-3-sulfatase.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
Protein: B2J_SICPA
Sequence: WIMGHMVNAIEQVDEFLNLGANAIEFDIDFDENGIAKYTHHGIPCDCGRLCTKSAVFTEYLDYVRQVTSPGDPKFRKELVLLALDLKLQRISSEKAYAAGVDVATKLLDHYWKRGWNGGRAYILLNIPLVEDYEFIKGFKDTLRKEGHEQYNAKVGINFTGNEDLDEIRKVLEKLGEDEHIWQADGITSCFPRGTDRLEKALEKRDTPGYKYISKVYAWTLVRSSIMRRSLRLDVDGVMSNYPDRVVGVLQEKEFANKFRLATYADNPWEKFMRI
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SpaSicTox-betaIIA3, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ALR_LIMF3
Sequence: MVSARLRKTDLVVDLKALGANVQRQREQLAPGSRILAVVKANAYGNGMVPVASALARAGVEGFCVALLDEAIELRDSGIQELVLVLGITPVEYAPLAAAQGISLTVGSLEWLKNYQRLAKEEGIKQPLKVHLALDTGMGRIGFTTPEDFKEALQLVAAPCFEFEGIFTHFATADEEDATYFERQRARFDDFMAVVTKRPPFVHVANSATGLWHQKSIVANTIRMGISMYGANPSGVGIKESFPLEPVTSLVTHATYVKQLKAGESVSYGATYTAKEDEWVATLPVGYADGYPRRMQGFYVLVDGQRCEVLGRVCMDQMMVRLPKEYPVGTEAVLMGRSLDQEITVTDVAEYAHTINYEILTGMGARLHRRYLG
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: TGL_BACC0
Sequence: MIVIGRSIVHPYITNEYEPFAAEKQQILSIMAGNQEIYSFRTSDELSFDLNLRVNIITSALELFQSGFQFRTFQQSFCNPQYWKRTSLGGFELLPNIPPSIAIQDIFKNGKLYGTECATAMIIIFYKALLSLYEKETFNRLFANLLLYTWDYDQDLKLITKTGGDLVPGDLVYFKNPQVNPATIEWQGENTIYLGNFFFYGHGVGVKTKEEIIYALNERRVPYAFISAFLTDTITRIDSRLMSYHASPNTPQTSIGFIPIRDDAIVATVGNTTTVY
What is the function of this protein?
Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links.
What are the official names of this protein?
Protein-glutamine gamma-glutamyltransferase, Transglutaminase, TGase.
What is the protein family that this protein belongs to?
Belongs to the bacillus TGase family.
Protein: LAZY2_ARATH
Sequence: MKFFGWMQNKLNGDHNRTSTSSASSHHVKQEPREEFSDWPHALLAIGTFGTTSNSVSENESKNVHEEIEAEKKCTAQSEQEEEPSSSVNLEDFTPEEVGKLQKELMKLLSRTKKRKSDVNRELMKNLPLDRFLNCPSSLEVDRRISNALSAVVDSSEENKEEDMERTINVILGRCKEISIESKNNKKKRDISKNSVSYLFKKIFVCADGISTAPSPSLRDTLQESRMEKLLKMMLHKKINAQASSKPTSLTTKRYLQDKKQLSLKSEEEETSERRSSSDGYKWVKTDSDFIVLEI
What is the function of this protein?
Involved in the regulation of root gravitropism (PubMed:27748769).  Functions redundantly with LAZY3 and LAZY4 in the control of root gravitropism (PubMed:27748769).  Functions redundantly with LAZY1, LAZY3 and LAZY4 to control plant architecture by coupling gravity sensing to the formation of auxin gradients (PubMed:28821594).  Involved redundantly with LAZY1 and LAZY4 in the regulation of both shoot and root gravitropism (PubMed:28765510).  Mediates gravity signaling in statocytes downstream of amyloplast displacement, leading to the generation of asymmetric auxin distribution in gravity-responding organs (PubMed:28765510).  Regulates the direction of polar auxin transport in response to gravity through the control of asymmetric PIN3 expression in the root cap columella (PubMed:28765510).  Regulation of auxin flow by the three proteins LAZY1, LAZY2 and LAZY4 in statocytes influences plant architecture by controlling the growth angle of lateral shoots and lateral roots (PubMed:28765510).
What are the official names of this protein?
Protein LAZY 2, AtLAZY2, Protein DEEPER ROOTING 3, AtDRO3, Protein LAZY1-LIKE 2, Protein NEGATIVE GRAVITROPIC RESPONSE OF ROOTS 1, AtNGR1.
What is the protein family that this protein belongs to?
Belongs to the LAZY family.
Protein: Y4OX_SINFN
Sequence: MTYKVLHIGAGGFGERWCDTFLPQNVADGTIEVVGLVDIDAKALDIGRKHLGLKAEQCFTAAAQAFQMVDADFCTIVIPPALHEGIVDLALARGMHILSEKPIADTMEASVRIAEKVRKSGLNMGVTMSHRFDQDKSTLRALVGADAIGRVNTVSCRFAGDFRLYDSWGRFRHEMMHPMLIEGAVHHLDIMADLAGAPCTSIYARTWKPEWADYKGDTDAIVLMDFANGAHGVYEGSSAQATGLNDWAFEYVRVEGESGTAILDHREIEVFHRYPMRLRQASRQGKGQQVSLLPGRKWQNALLIEQFCQWLDSGPPMATNVWENLQSVALVFSAIESVRLGQPVKVQEFLQSYRVGASIE
What is the function of this protein?
Could be a NAD-dependent oxidoreductase.
What are the official names of this protein?
Uncharacterized protein y4oX.
Protein: NUOB_SALSV
Sequence: MDYTLTRIDPNGENDRYPLQKQEIVTDPLEQEVNKNVFMGKLHDMVNWGRKNSIWPYNFGLSCCYVEMVTSFTAVHDVARFGAEVLRASPRQADLMVVAGTCFTKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFIPVDVYIPGCPPRPEAYMQALMLLQESIGKERRPLSWVVGDQGVYRANMQPERERKRGERIAVTNLRTPDEI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NDK_FRAP2
Sequence: MNKQRTLSIIKPDAVEKNIIGEIYRRFEKSGLKVVAAKMKHLSKAEAEGFYAVHKDRPFFSALVEFMISGPVMIQVLEGDNAIAKNRKLMGATNPKEAEAGTIRADFADSIDANAVHGSDAPETAAQEIKYFFSDIEIVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP2_CTFVL
Sequence: MSARTKEKTKDKTKNDEQTVSTEASAADRNDREKSSSSEPEDNAKETLTKKDSSSKKSVDVLAAMIEQKVQMSGSAGLGEFFGRMRPEITDAFFAALEREADVSKVVPSSLSKLDDGQVVDLLSVGEERTLSQSLFQLEVVTSIPHFYQLTAKQIGALGAQGGYLKAYHGEQVYPFIDPVANQFGRGFDLAYVRINTSGQGVELFIDPFDFDKVSCKVGGESLTGIGLSNAVGVDEITYDDVKTPEQMMEFVVLLIAGAAKMGRFCSSGVDARRRRKLFKTWVRRPVSDNFRHVQGWLLEDDYENYPHVPEALTVFSEYQWFAREVADNMTDNGLGTSVQMEDGPNIESFFNRKYREAAICNLDFITAEAHANVMEELQNEKMNVSAYVDLLQSCQMGIFDIEGDTDTIKLKVYMREVEDYEAELTRMMLFPGDQLYVDCLRTAALVSPNIRQFILSVLIQQATSRVGLIELLPVAEMTASLTSRDNISVSHNMALTLAIGEWKELLRLTNPQQICQKIVCDIMAPFVDGLRMEDSLGVPTPSKLVFSLLGAKVALILTPNLYDYNLHLKAHLVTMILSCFFPDQYGALIASRGYGHDVTGNRIDSIRDGERTKKNCRFATYTVLDPIPNGPPDRTRRKWLLMKRVQEWLLRNDLVRRREIRDIIYRPYANVLRLPGQTYLPRRQAAGAPLPCEVLLNDAIAILEEYRTVFHHPNDRNQGPQDRHALTTLSNLLRWYTRGFAEWFHWVYRPLYLQIALHPIIFWSHRLGQGVWRQFPAVREDRERRFDNHLEGVPFDSPVIAAFEPDVALNPFTLRQGADLLGRVHAQGSTFRGGAYDSASVILLSEYEALYRMTDSEGMVDEYIKTLMASRQLLEGLRLVAELSTGELLRDTPILDYIRTAFCEGRFPSHIFFKILNLFGVKINHGVLAQVGERSIEHRLRGDYRVYYPRPGFLDPALEFIPDRIVVVDPVRPSVRRNVKLIMDAVFDPEFGMIKMRKGVTFSLRPTNDLTFSSFHEIPPIQVEMTGNVNYVYDSETARTRAEYDVQVRWEAPGRIITMNLLVTSSYEILSSMEDILGREVRAFSFVVQDVSKFSGIYYDFMLSAVRKEHAIVWFPNLRGILHHHAISIEKVETCFKAAELAQFSSFLSLRPTALIKLNVVQTTNIRGGILPPSVSKPILPCEGVHPSFIFALMSMWRRIGFAGLPSR
What are the official names of this protein?
Putative RNA methyltransferase VP2.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: RNZ_STRMU
Sequence: MEIQFLGTGAGQPAKARNVSSLVLKLLDELNEIWMFDCGEGTQRQILETTIKPRKIRKIFITHLHGDHVFGLPGFLSSRAFQANDEQTDVDIYGPVGIKHLVMASIRTSGAHLPYHIHFHEFDAKHLGKILETDKFMVYAEKLDHTIFCVGYRVVQKDLEGTLDAEKLKAAGLPFGPLFGRVKNGQDVVLEDGTTIIAKDYISAPKKGKVITILGDTRKTDASIRLALGADVLVHESTYSKGDENLARRHGHSTNTEAARVAKAASVKKLLLNHISARFLSHDISRMRDDAQEIFTDVHIVRDLEEVKL
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: RPOZ_BACC4
Sequence: MLNPSIDSLLQKIDSKYTLVTVAAKRAREMQLANNCVVEKPVSHKCVGKALEEIDAEALSYVPSEDKVAE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: DMSA_HAEIN
Sequence: MSNFNQISRRDFVKASSAGAALAVSNLTLPFNVMAKETQRLNENNQERIVWSACTVNCGSRCPLRMHVKDNRITYVETDNTGTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRIGKRGEGKFKRISWDEALTEIADALKRNIKKYGNESIYLNYGTGTLGGTMAKSWPPASTMIARFMNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGMADIENTKLIVLFGNNPAETRMSGGGLTYCIEQAKARSNAKMIIIDPRYNDTGAGREDEWIPIRPGTDAALVAALAYVMIQENLVDQPFLDKYCVGYDEKTLPTDAPKNGHYKAYILGYGNDGIAKTPEWAAKITGIPAERIIKLAREIGSTKPAFISQGWGPQRRSNGELISRAIAMLPILTGNVGIHGGNTGARESAYSIPFVRMPTLKNPVKASIPMFLWTDAIIRGTEMTALTDGIRGVDKLSSPIKVIWNYASNCLINQHAQINRTHDILQDDTQCEMIITIDNHMTSTAKYSDILLPDCTTSEQMDFALDAFVSNMAYVIFADQVIKPSFECRPIYDMLSDLAEKMGVKEKFTEGRTQEEWLRHIYEQSREKLPELPTFEEFRQQGIFKKVDPNGFKVAYKDFRDNPEAHPLKTPSGKIEIYSSRLAEIAKTWKLAEDDVIHPLPIHAQSFEHYGDPLMEKYPLQLSGFHYKARTHSTYGNVDVLKAANPQEVWMNPIDAEPRNIKNGDMIRIFNDRGEVHINVKITPRIIPGVVALSEGAWYAPDKDRIDHSGCINVLTTQRPSPLAKGNPQHSNLVQVERL
What is the function of this protein?
Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS).  The terminal DMSO reductase can also use various sulfoxides and N-oxide compounds as terminal electron acceptor in addition to DMSO (By similarity).
What are the official names of this protein?
Dimethyl sulfoxide reductase DmsA, DMSO reductase, DMSOR, Me2SO reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.