PharMolix/UniProtQA huggingface dataset:
Protein: CTNA1_MOUSE
Sequence: MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVVAVEDVRKQGDLMKSAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGNRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDAAQHQGGSGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI
What is the function of this protein?
Associates with the cytoplasmic domain of a variety of cadherins.  The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.  Can associate with both E- and N-cadherins.  Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions.  In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components.  The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments.  Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:21145499).  May play a crucial role in cell differentiation.
What are the official names of this protein?
Catenin alpha-1, 102 kDa cadherin-associated protein, Alpha E-catenin, CAP102.
What is the protein family that this protein belongs to?
Belongs to the vinculin/alpha-catenin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell- matrix boundaries.
Protein: MOBA_BACSU
Sequence: MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVIISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQRRTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRISVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Probable molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_TRICV
Sequence: MINNSDTLKIGNKTFNSRLMLGSGKYRTIENAVNSIITSDCEILTVAVRRLPTKLTNDNTSFLKSLDWNKLWLLPNTAGSQTAEEAIRMAFLGHELACQLGQEDNFFVKLEVISDPKYLLPDPIGTLKAAEFLVKKGFTVLPYINADPMLALHLEDLGCATVMPLGSPIGSGQGLNNISNLQIIIENSSIPVIIDAGIGTPSEAAKSMELGADGVLLNTAIAQAKTPEKMALAMKLAVEAGRLGYLAGRMEKNRMQVQVLH
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PGLR1_ASPFN
Sequence: MHFQLLGLAALGSLAAAAPAPSRTSELVERGSSCTFTSAAQASASAKSCSNIVLKNIAVPAGETLDLSKAKDGATITFEGTTTFGYKEWKGPLIRFGGNKITVTQAAGAVIDGQGSRWWDGKGTNGGKTKPKFIYAHKLQSSTIKGLHVKNSPVQVFSVQGNDVHLTDITIDNSDGDNNGGHNTDAFDVSESNGVYITGANVKNQDDCLAINSGENIEFTGATCSGGHGISIGSIGNRDSNTVKNVKVADSTVVDSDNGIRIKTISGATGSVSGVTYENITLKNIKKNGIVIEQDYKNGGPTGKPTTGVPITDLTVNGVTGSVASKATPVYILCGKGSCSDWTWKGVSISGGKKSDKCQNIPSGASC
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.  Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall (By similarity).
What are the official names of this protein?
Probable endopolygalacturonase I, Pectinase 1, Polygalacturonase I, PG-I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLPP_CAMJJ
Sequence: MFIPYVIEKSSRGERSYDIYSRLLKDRIIMLSGEIHDELAASIVAQLLFLEAEDPTKDIYLYINSPGGVITSGFSIYDTMNYIKPDVCTICIGQAASMGAFLLSCGAEGKRFALPNSRIMIHQPLGGARGQATDIEIQAKEILRLKTILNDILAKNTKQKVAKIAKDTERDFFMSTQEAKEYGLIDKVLEKSFK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCAA_STAS1
Sequence: MRKCPKCGGNMRDKQSKCGHCGYEVTDNHSEQLTRSLKDNKKSANIKARKIIPWGIAFFIIILLIIIFFLLKNFNSPEAQSELLINAVDNNDTQKLSTILSTQNNSVDETEATAYIKYIKNEVGMDNFVKDVNQKIKKLNESETKEADFVTAKNGENVLRVSKNGRRYLIFDNMSFTAPTKEAIVKPKYDATYKFKSDDKQKTVTAEKNKTTAIGKFIPGDYLLETKKETANGQFDGQLKFNFNNSNNETIDVSEDFNEAYIQVELSGASEIDKDTVKVKINDKTYDYAKAKEIGPYPKTNDITVSAEGEAKKKTFKSAETTVKTDNLKDKTKVTLNFDDDEIQSYVDKKEKEENSFRNKVTNFFGNFTTAMNSAHSQSDFSLVSSYLKKNTDNYKSTKSDVNSNRLFFIQQPQITEIIKQGNTFYVTGQALKENGQYGEVDYQLQGDGDADNLKVVKYSE
What is the function of this protein?
Plays a major role in decreasing resistance to glycopeptide antibiotics.
What are the official names of this protein?
Membrane-associated protein TcaA.
What is the protein family that this protein belongs to?
Belongs to the TcaA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: TRMB_UREP2
Sequence: MRLRNNANAPLYLKSQHEYIINDPHLLKDNLGKIFKNPELPLYIEIGMGKGDFIIENALRNQQINYLGIEKFPTVIVKAHKKALKHKLDNLAMICFDANKILELLNSESVDKIYLNFSDPWPKKRHAKKRLTHPCFLEKFAVILKQNALVEFKTDNENLFMYTIYDVLLKDLTKYEILFLTYNLYTLVNNVELLKNIPTEYEKKFVMQGERIKKVNFRFLKNNQ
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: HDHD3_HUMAN
Sequence: MAHRLQIRLLTWDVKDTLLRLRHPLGEAYATKARAHGLEVEPSALEQGFRQAYRAQSHSFPNYGLSHGLTSRQWWLDVVLQTFHLAGVQDAQAVAPIAEQLYKDFSHPCTWQVLDGAEDTLRECRTRGLRLAVISNFDRRLEGILGGLGLREHFDFVLTSEAAGWPKPDPRIFQEALRLAHMEPVVAAHVGDNYLCDYQGPRAVGMHSFLVVGPQALDPVVRDSVPKEHILPSLAHLLPALDCLEGSTPGL
What are the official names of this protein?
Haloacid dehalogenase-like hydrolase domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
Protein: GUN_ASPAC
Sequence: MKAFHLLAALAGAAVAQQAQLCDQYATYTGGVYTINNNLWGKDAGSGSQCTTVNSASSAGTSWSTKWNWSGGENSVKSYANSGLTFNKKLVSQISQIPTTARWSYDNTGIRADVAYDLFTAADINHVTWSGDYELMIWLARYGGVQPIGSQIATATVDGQTWELWYGANGSQKTYSFVAPTPITSFQGDVNDFFKYLTQNHGFPASSQYLITLQFGTEPFTGGPATLSVSNWSASVQ
What are the official names of this protein?
Endoglucanase-1, Cellulase, Endo-1,4-beta-glucanase, Endoglucanase I, FI-CMCase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 12 (cellulase H) family.
What are the subcellular locations of this protein?
Secreted.
Protein: TSAP1_MOUSE
Sequence: MAASLWMGDLEPYMDENFISRAFATMGETVMSVKIIRNRLTGIPAGYCFVEFADLATAEKCLHKINGKPLPGATPAKRFKLNYATYGKQPDNSPEYSLFVGDLTPDVDDGMLYEFFVKVYPSCRGGKVVLDPTGVSKGYGFVKFTDELEQKRALTECQGAVGLGCKPVRLSVAIPKASRVKPVEYSQMYSYSYNQYYQQYQNYYAQWGYDQNTGSYSYSYPQYGYTQSTMQTYEEVGDDALEDPAPQLDVTEANKEFMEQSEELYDALMDCHWQPLDTVSSEIPAMM
What is the function of this protein?
Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins.  Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex.  May be involved in the methylation of tRNA(Sec).  Enhances efficiency of selenoproteins synthesis.
What are the official names of this protein?
tRNA selenocysteine 1-associated protein 1, SECp43, tRNA selenocysteine-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the RRM TRSPAP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Abundant in the nucleus.
Protein: RAF1_CHICK
Sequence: MEHIQGAWKTISNGFGLKDSVFDGPNCISPTIVQQFGYQRRASDDGKISDTSKTSNTIRVFLPNKQRTVVNVRNGMTLHDCLMKALKVRGLQPECCAVFRLVTEPKGKKVRLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSNISDSGVPALPPLTMRRMRESVSRIPVSSQHRYSTPHVFTFNTSNPSSEGTLSQRQRSTSTPNVHMVSTTMPVDSRIIEDAIRNHSESASPSALSGSPNNMSPTGWSQPKTPVPAQRERAPGTNTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCLKKVREERPLFPQILSSIELLQHSLPKINRSASEPSLHRASHTEDINSCTLTSTRLPVF
What is the function of this protein?
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions.  RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity).
What are the official names of this protein?
RAF proto-oncogene serine/threonine-protein kinase, C-MIL, C-RAF, MIL proto-oncogene serine/threonine-protein kinase, RAF-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane.
Protein: DNAJ_EHRCR
Sequence: MSKSDYYDLLGVSKSATPEEIKKAYRKMALKYHPDKNPGNKEAEEKFKELSEAYDVLIDQDKRAAYDKYGHNAFDSSGRGGFDFNSGFSGDFSDIFNDLFGGGFRGGRGSSRRHDSGAVGSDLRFDIEITLEDSFNGKKVPISYVTYVKCSSCSGSGSEGSAKSVQCSTCHGVGNVRTQQGFFTIERTCHVCNGEGEIIQNKCKKCSGSGRVRDEVNLLVTIPKGIESGNKIRLNGKGEAGYRGARSGDLYVYSNIQKHKFFTRNGSDLYCNVPIKMTLAALGGHIEMPSIDGTWTKVKVPEGSQNGDKLRLKEKGMPIINSSKRGDMYIQITVETPVKLTKKQKELLQKFDDEPNVDCNPQSTGFFQKVKSFWKDIRSN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_NOSS1
Sequence: MDIYKFAVRPLLFDLVKADPEWLHQQTMRSLSWLSHTSDRTSTKWVQNILQKSLCLEDSRLEQNLFGLRFPNPVGLAAGFDKDGVAARIWSSLGFGFAELGTVTFVGQPGNPPPRLFRLPLDQAALNRMGFNNHGAAVMAARLADEKGQFSIPIGINLGKSKVTPLEAAAEDYLNSFRLLKELGDYFVVNVSSPNTPGLRSLQDASMLSSILDVLQKENNSHKPIFVKIAPDLEWEAIADIIGLAKTYQLAGIIATNTTIRRDGLKTQVIEQTGKAPQEEAGGISGAPVRDRSTEIIRFIWQQTQGEIPIIGVGGIFTPEDAWAKITAGASLIQVYTGWIYQGPMMVSQILTGLLSKLEEHELNSISEAIGLEFKS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PNC1_SCHPO
Sequence: MSFHPALIIVDVQNDFVHPVYISSGESALEVVPVINRLLENDYKWDTVIATKDVHPKDHLSFTTSHSSTPKPSGTVVNIEAYGHVYKQTLWNSHCVENTPGCEFPDSLNGDRIEFVIPKGSDRLVESYSGFYDAIGRDNGLKAILDKKGITDVFIAGVATDICVKETALHARHWYNTYIISEAVKGSSTESHNQAIKDFRDAKIEVISEKDPILQSVRKV
What is the function of this protein?
Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway.
What are the official names of this protein?
Nicotinamidase, Nicotinamide deamidase, NAMase.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Peroxisome.
Protein: ACPS_BAUCH
Sequence: MAILGIGTDIVEIARIHTVLVRCGERFIDRILSPIEYKQYHQQNNSVHFLAKRFAVKEAAAKALGTGICHGIAFVQFELFHDERGKPQLRLHEQAAQLARERHITRMHVTLADERYYTCAMVIFEGDIRSNDYSIQPNWYLSKIKP
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RP54_PSEPK
Sequence: MKPSLVLKMGQQLTMTPQLQQAIRLLQLSTLDLQQEIQEALESNPMLERQEDGEDFDNSDPMADNAENKPAAEVQDNSFQESTVSADNLEDGEWSERIPNELPVDTAWEDIYQTSASSLPSNDDDEWDFTTRTSAGESLQSHLLWQLNLAPMSDTDRLIAVTLIDSINGQGYLEDTLEEICAGFDPELDIELDEVEAVLHRIQQFEPAGVGARNLGECLLLQLRQLPATTPWMTEAKRLVTDFIDLLGSRDYSQLMRRMKIKEDELRQVIELVQSLNPRPGSQIESSEPEYVVPDVIVRKDSDRWLVELNQEAIPRLRVNPQYAGFVRRADTSADNTFMRNQLQEARWFIKSLQSRNETLMKVATQIVEHQRGFLDHGDEAMKPLVLHDIAEAVGMHESTISRVTTQKYMHTPRGIYELKYFFSSHVSTSEGGECSSTAIRAIIKKLVAAENQKKPLSDSKIAGLLEAQGIQVARRTVAKYRESLGIAPSSERKRLM
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is responsible for the expression of the xylCAB operon and the xylS gene.  The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein XylR for the expression of the xylCAB operon and xylS.
What are the official names of this protein?
RNA polymerase sigma-54 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-54 factor family.
Protein: CYB_RHEAM
Sequence: MAPNIRKSHPLLKIINSSLIDLPSPSNISAWWNFGSLLGICLITQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLYKETWNTGVVLLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFLIAGITLIHLTFLHETGSNNPLGIVSHSDKIPFHPYFSLKDALGFALMFIPLLTLAFFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRSMTFRPLSQILFWLLVANLLILTWIGSQPVEHPFIIIGQMASFSYFLILLVLFPAIGALENKMLY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PANC_BACVZ
Sequence: MKQLTETQQLKELIAQYRSEGRTIGFVPTMGFLHEGHLTLVEKASKENDIVVMSIFVNPTQFGPGEDYEAYPRDLKRDARLAEQAGADVLFTPSPSDMYKGEQNVAVQVKRRTDVLCGASRVGHFDGVATVLTKFFNLVKPTRAYFGLKDAQQAAVVDGLIEDFFMDIELVAVDTVREEDGLAKSSRNVYLTEQERKEAPMIYKALQQGAELIRDGERNPETVIKTVTDIIENTSGVIDYAELYAYPELTPLKTLNGKVILACAVQFSKARLIDNIIIDIDEWERS
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_SYMTH
Sequence: MKRALISVYDKQGIVEFARGLADLGVEIISTGGTYRTLQGAGIPVREVAEVAGFPEILDGRVKSLQPQIHAGILAMRANPTHMAQLAEHGIGLIDLVVVNLYPFRETVANPAVTLEEAIEKIDIGGPAMVRAAAKNYQDVGVVVNPARYPAVLAELRETGDLSLPTRFSLMLEAFQHTAAYDGAIAGWMATRGREIVATRALGETAPERPIGADPGPQKPAAPSPFPDVLSLTFTKVQELRYGENPHQAAAFYSDGSDGGTVIARAKQLHGKELSFNNINDAHAALELVKEFEEPAAVAIKHANPCGVAVAPTIAEAFRKAYEADTVSIFGGIVALNRPCDRETAEALSKIFLEIVIAPAFAPEALEVLTRKKNLRLLAVGPIDRNPPSGFDMKRVGGGLLVQSWDAIAEDPVAWKPVTKAAPTPEQLRDLAFAMKVCKHVKSNAIVVARDGQTLGVGAGQMNRIDAARFALRQAGEKARGAVLASDAFFPFPDVVEAAGEAGIAAIVQPGGSIRDEESIARADELGLAMVFTGVRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: MKAR_EMENI
Sequence: MEYLKDISSSLSGWEFNFAPGWQSVTASVLLVAGGWFVVSRVWTFLRVLTSLFVLPGKSLRSFGPKGSWAIVTGASDGLGKEFALQIARAGYNIVLVSRTASKLTALTDEITSKYPSVQTKMLAMDFARNLDEDYEKLKALIQDLDVAILINNVGKSHSIPVPFALTPEDELADIITINCMGTLRVTQLVVPGMTQRKRGLILTMGSFGGLVPSPLLATYSGSKAFLQQWSTALGSELQPYGITVELVQAYLITSAMSKIRKTSALIPNPRAFVKATLSKIGNNGGSPGYAYSSSPYWSHGLVAYLATCVINPMSKWLANQNKAMHESIRKRALRKAERENAKKSS
What is the function of this protein?
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate.  Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation.  VLCFAs serve as precursors for ceramide and sphingolipids.
What are the official names of this protein?
Very-long-chain 3-oxoacyl-CoA reductase, 3-ketoacyl-CoA reductase, 3-ketoreductase, KAR, Microsomal beta-keto-reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: Y489_STAAR
Sequence: MDSHFVYIVKCSDGSLYTGYAKDVNARVEKHNRGQGAKYTKVRRPVHLVYQEMYETKSEALKREYEIKTYTRQKKLRLIKER
What are the official names of this protein?
UPF0213 protein SAR0489.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: PRIS_SULIN
Sequence: MGTFTLHQGQSNLIKSFFRNYYLNAELGLPNDMELREFALQPFGSDTYIRHLSFSSSEELRDYLVNRNLPLHLFYSSARYQLPSARDMEEKAWMGSDLLFDIDADHICKLRSIRFCPVCGNAITSEKCERDNVETLEYVEMTSECIKRGLEEARNLVEILEDDFGLKPKVYFSGNRGFHVQVDCYGDCALLDSDERKEIAEYVMGVGVPSYPGGSESAPGWVGRKNRGINGVTIDGQVTIDVKRLIRIPNSLHGKSGLIVKEVTNLDDFEFNEALSPFTGYTIFLPYISIETEVLSRNIKLNRGVPIKIESSIGIYLHLKNLGEVKAYVR
What is the function of this protein?
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  The small subunit contains the primase catalytic core and has DNA synthesis activity on its own.  Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase small subunit PriS.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: RS5_RICRO
Sequence: MSKVKKNDETLSEVLVDVNRVTKVVKGGRSFAFSAYVVVGDKAGRVGAGHGKAKEVNEARGKAKQAAKKRMMKVPLYQNRTIHHDVVGKSGAAKVILRRAKAGTGVIAGGSMRAIFDSLGIHDVVAKSIGSTNVYAMISATFDALNKLASPKSIAMRRDKKVNEISVKSADIQVNE
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: AROE_BRUME
Sequence: MDDKSMARGRKAFVTGFPIRHSRSPLIHGFWLKELGIDGSYEAVEVKPEDFSSFAASLAANGFAGGNVTIPHKEAAYAAAESLDEAARAIGAVNTLWLENGRLCGGNTDAYGFAANLDASAPGWDKADRALVLGAGGASRAVVHALLSRGVCHVSVVNRTLSRAEELAAHFGARVYAHGWDEAQALVSNAGLIVNTTALGMSGHGEGQDFPIDLTCAPKEAVATDIVYVPLRTAFLNKAEKAGLKTVDGLGMLLHQAVPGFERWFGQRPQVTQALREHILADMAKAGAL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: GLYA_VESOH
Sequence: MFDKSQTLAKVDAEIYKAIVLEETRQETHIELIASENYTSPAVMETQGSKLTNKYAEGYPCKRYYGGCEYVDMVEQLAIDRAKTLFGADYANVQPHSGSQANAAVFQALLVPGDTILGMSLAHGGHLTHGATPSFSGKNFNSIQYGLNQKTGEIDYEQVEVLAKRYKPKMIIAGFSAYSRMVDWQRFREIADSVGAYLMVDMAHVAGLIATGEYPSPVAIADVTTTTTHKTLRGPRGGLILAKSNKTIEKKLNAAIFPGIQGGPLMHIIAAKAVSFKEAMSDEYKTYQKQVKINAQVMANTFIKRGFDVVSGGTDNHLFLVSFIDQGLTGKAVDTALGSAYITVNMNAVPNDPNPPFVTSGIRVGTPSVTTRGFNEIDCSDLASWMCDICDDLGNQEVIYKIRGRVVSLCAKYPVYLDD
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_METMP
Sequence: MIKDERWEGVYSFEDSPYLMETLTNLRNVSTENISFRKGLVRLGRYMGYELTKTMEFEEMHVQTPLEKTKGIFPKDRSNVVIITILRAAFPLMEGLIKNFESAKVGIVSASRGHAPDFKIEMNYIKVPQVTPEDTVIVSDPMIATGSTLIHVLKEFKDSKPKRMMIVGVLAAPEGINAVKAEFPDVEIFVTKIDDKLNNDGYIVPGLGDAGDRAFGEPFKVSMLPQMHNLE
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.