PharMolix/UniProtQA huggingface dataset:
Protein: ARGA_PSEPG
Sequence: MPDYVNWLRHASPYINAHRDCTFVVMLPGDGVEHPNFGNIVHDLVLLHSLGVRLVLVHGSRPQIESRLADRGLTPHYHRGMRITDAATLDCVIDAVGALRLAIEARLSMDIAASPMQGSRLRVASGNLVTARPIGVLEGVDYHHTGEVRRVDRKGISRLLDERSIVLLSPLGYSPTGEIFNLACEDVATRAAIELGADKLLLFGAEPGLLDADGKLVRELRPQQVAPHLQRLGSDYQGELLDAAAEACKGGVARSHIVSYAEDGALLTELFTRGGGGTLVSQEQFEVVREASIEDVGGLLELISPLEEQGILVRRSREVLEREIEQFSVVEREGMIIACAALYPIADSEAGELACLAVNPEYRHGGRGDELLERIESRARQMGLNTLFVLTTRTAHWFRERGFAPSGVERLPAARASLYNYQRNSKIFEKAL
What are the official names of this protein?
Amino-acid acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ArgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN1_HETP5
Sequence: MGIKNLTSLIEENAPSAIKSNDLKSYSGRIVAIDASTSMYQFLIAINTEMGAALMNANGETTSHLQGMFYRTIKLMTRGIKPIYVFDGKAPVLKSGELAKRYARRKEAEQQLEEANEVGNSEDVQKFQKRTISASRKQNEECKKLLELMGVPIVQAPCEAEAQCAELCKGGKAWATGSEDMDSLTLGTTILLRRLTFSEARKLPIMEIELEKVLDGLDLTHDQFVDLCILLGCDYCDTIKGIGPKKSFDMITKHKNIQTVIQNIDRTKNPIPESFPYEEVRELFKNPDVIKCQDLPEIVWKEPDVDGLIKYLVGEMGFNETRVQQGIEKLKKYKDTGVQTRIDTFFPMIKRPRDEDAGSAKKKQKTVAKPGAAGSKKKPAAKKAAGKK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: ATPF_STRP4
Sequence: MHVTVGELIGNFILITGSFILLLVLIKKFAWSNITGIFEERAEKIASDIDRAEEARQKAEVLAQKREDELAGSRKEAKTIIENAKETAEQSKANILADAKLEAGHLKEKANQEIAQNKVEALQSVKGEVADLTISLAGKIISQNLDSHAHKALIDQYIDQLGEA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RS11_CALS4
Sequence: MAKRVKRAGRKREKKHVERGIAHIHSTFNNTIVTITDPAGNTIAWASAGTVGFKGSRKSTPFAAQMAAESAAKAAMDHGMRTVDVYVKGPGAGREAAIRALQAAGLEVSLIKDVTPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: AROQ_ACISJ
Sequence: MTKTVYVLNGPNLNLLGTREPQVYGSQTLADVEQLCTAACARHGLALVFRQSNHEGALVDWIHEAGRLHAAGQLAGVVLNAAAYTHTSVALLDAVKGTGVPVVELHISNVHARESFRHHSYLAGAARAVMCGFGVQGYALAIDGLAQW
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: CYSA_BURMA
Sequence: MGITVRNLHKRFGEFAALDDVSLDFPAGELVALLGPSGCGKTTLLRVIAGLEHADSGQVVLQGLDVASVGARERQVGFVFQHYALFRHMTVFENVAFGLRVKPRRERPSEAAIRAKVHELLSLVQLDWLAQRYPSELSGGQRQRIALARALAVEPKVLLLDEPFGALDAKVRKELRGWLRRLHDDLHISTIFVTHDQEEALEVADRIVVLNHGRVEQVGSPQAVYDHPRSAFVYEFLGAANRLDGTVSGNGFVAHGAAQAIAVDADFAGPARAYVRPHDLELAAPHARAQGIAADVRRVVPLGGSVRVELAARSGEVLEAELDRNAWRALALDVGDALTAVPRAVRVFPAR
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KITH_MALP2
Sequence: MKNNAFGKEKGWIELIYGPMFAGKSEELLRKLKRLDYADVIYQVFKPKIDTRTKNKIMSRDGRNMDSFEFDNPYEIFDKLLSLEVNPHVVAIDEAQFADESIVDVCQALADSGYIVYVSALDKNFKNEPFMVTAKIACIAEYVEKLSAICTDCGAPGTATQRIINDKPSNYDEPVVQIGNYETYTVKCRHHHKIPGKPFPEEIKKFKSDLRNLLKNKENK
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_STRPG
Sequence: MTNSFQNSRRDLRERAFQALFNIEMGAELLAASQFAYGYDKVTGEDAQVLELPIFLLSLVTGVNNHKEELDNLISTHLKKGWSLERLTLTDKTLLRLGLFEIKYFDETPDRVALNEIIEVAKKYSDETSAKFINGLLSQYVSEAPSANKS
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: GREA_NITHX
Sequence: MIEKVPMTRGGHAALADELKKRQSVDRPRIIEHIAEARSHGDLSENAEYHAAKEDQSHNEGRIAELEDKLARAEIIDVSKLSGDTIKFGATVTLIDEDTDKKAVWQIVGEAEADAKKGRISITSPLARALIGKKKGASVEVVAPGGAKAYEITKVEWR
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: ACSA_YERPA
Sequence: MSQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSFDPGHVSIRWFEDGTLNLAANCLDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQFANVLKSLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPDAVAGRIIDSHSKLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDLIKEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPLACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTAIRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYNKIGNSKCPIVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGDHERFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGVPHNIKGQAIYAYITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEKLLEEKQSMQTPS
What is the function of this protein?
Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt.  Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: IAA28_ARATH
Sequence: MEEEKRLELRLAPPCHQFTSNNNINGSKQKSSTKETSFLSNNRVEVAPVVGWPPVRSSRRNLTAQLKEEMKKKESDEEKELYVKINMEGVPIGRKVNLSAYNNYQQLSHAVDQLFSKKDSWDLNRQYTLVYEDTEGDKVLVGDVPWEMFVSTVKRLHVLKTSHAFSLSPRKHGKE
What is the function of this protein?
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.  Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE).  Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
What are the official names of this protein?
Auxin-responsive protein IAA28, Indoleacetic acid-induced protein 28.
What is the protein family that this protein belongs to?
Belongs to the Aux/IAA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARGC_RHIL3
Sequence: MAPKIFIDGEHGTTGLQIRTRMAGRRDVELLSIPEAERRNAAMREDMLNGADIAILCLPDDASKEAVQMVSANNNVRVIDTSTAFRVNPGWAYGFAEMDKQQADKIAAARFVANPGCYPTGAIGLIRPLRAAGILPDGYPITVNAVSGYTGGGKQMIAQMENPDHPDAITAPHFLYGLPLTHKHVPEMTVHGLLDRAPIFSPSVGKFAQGMIVQVPLHLDDLAEGTTMESIHAALVAHYAGQDIVSVVPLAESKALPRVNAIELEGKDTMKLFVFGTPGASQVNLVALLDNLGKGASGAAVQNMDLMLAS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCLQ_BACSU
Sequence: MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLDKNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGSLKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIGKIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHDVFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVKNVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK
What is the function of this protein?
Part of the ABC transporter complex YclNOPQ involved in uptake of ferric-petrobactin.  Petrobactin is a photoreactive 3,4-catecholate siderophore produced by many members of the B. cereus group, including B. anthracis.  Binds selectively iron-free and ferric petrobactin and the petrobactin precursor 3,4-dihydroxybenzoic acid (3,4-DHB).
What are the official names of this protein?
Petrobactin-binding protein YclQ.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 8 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Membrane raft; Lipid-anchor. Note=Also found in the extracellular protein fraction (PubMed:10658653). May exist in both membrane-tethered and soluble form (Probable). Present in detergent- resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion (PubMed:23651456).
Protein: SCG2_PELRI
Sequence: MSSQRNYCLAGCLSSCILVILMSFSDAASFQYYQVPQQDQEYRMKTLQRLPSPDMLKALEYIENLRKQASRTESLPDYTSYQGAPFLSEQKDTQALSTDTAKSPTSDDESEWMRAMLEALMQAEKEAKVSPQEKNNLYMDKNIPPELIEDYDSNKWSEKRPKAGKFSSRLYDDYSRDNPLKRTNEIVEGQYTPQSLATLQSVFQELGKLKGQANNKRDRMEEDQKLYKDDEDDLYKANNIAYEDVAGGEDWNPIEEKVESQTQEELKESKEEVEKTDDMEDEIKRSGLLGLQDEEPEKDTKEQESENLSNLMNTYLNMWMNRMDKGKQNPDRRSLRFSGKELDPEAIYQLIDISRNLQIPPEDLIDMLRDEDGRKFGGRLESEKEVDVPLDLDEVTETMTDKTNVYKNKQGFVRQPTSPVLPNIPEGLTVEDMVNLMGADKLQNRFKQNNGLQRPYPMLSKIKGHKAIWPKESEKRQIEYESRPEKEEELADYVVKMLAKYPELLGNNQNKKMPIPYSAGDLQELEKQYENALRGYVNMRGYQDLETVSSSNRRLSTRENDDTQNKQYIDEDLLMKVLEYLNQEKAEKARDHSVKRSMENM
What is the function of this protein?
Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
What are the official names of this protein?
Secretogranin-2, Secretogranin II, SgII.
What is the protein family that this protein belongs to?
Belongs to the chromogranin/secretogranin protein family.
What are the subcellular locations of this protein?
[Secretogranin-2]: Cytoplasmic vesicle, secretory vesicle. SUBCELLULAR LOCATION: [Secretoneurin]: Secreted.
Protein: PTH_THEMA
Sequence: MVVVGLGNPGPRYAFTRHNVGFLFLDFLKNKDWKTEKYFAWNKINLAGNEVALVKPLTYMNLSGLAMPHVLKFFSASLDDIIVVYDDVSLKLGKIRIRKKGSDGGHNGMKSIIQALGTQEIKRIRVGIGDKPEGMDLVNFVLGEFSDEEWIILNKVFEVMKEALEVILVEGIEKAMSIYNSLEVRA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_DEIRA
Sequence: MVAGRKAFALQAGDALSPDKPAEAQPAQVKTDLAANRQDAVFRYAQNGVQVTKTITLHPRNFKVDVRTEVRNGPAQVNMLFPGLGKADNPRVQAVPVGGQPASVQGSGTLSVQNIQYAALQENPSQIAHALIVRPQQGTKVDVQLTGGPQGLVTATLPATSSLEVYGGKNELIHLYQSGYTELPGLFQPNFFGQISLLIVKLMEALYKVIGNWGLVIMALTILLRLVMWPLMQAQGRTTARMQLVQPLQKEIQEKYKGKTDPESQRAMQMEMAQLMRDYQVNPAGCFSTLLPFPVLIALWATIRNFEFDSGFLWLPDLATPDPFYILAVIYLFVNLGQLYVSTRKTPEMFRQQAMIYLVFLYFALTFPSGVTLYIILSTIIGIVQQIIINKQVEHETASLGQTVQKVAPGTRPASKTTVTKTIDAPKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins (By similarity).
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NADK_METMA
Sequence: MCMRRFYICSQGDNLAIKRIGIASRCDRPEVLDMVREILARFSSQVQIFVSTATAEVLGIEGTPVERMRDEGVELVISVGGDGTVLRNIAKMKDPLPILGINMGTLGFLVDVEPEDAIETIEEVLYGFSYLERMRVDVFLNGEMLETATNEIAVMSAKPAKIIQFEVHVNDCLLDEMRADGVVFATPTGSTAYAMSAGGPIINPRVNAIVVVPVAPFKLSSRPWVIPADSEITVKLLEHKKDAVIAIDGQKSYRIRPEDIVKLKKSKFPARFVRISDTCFYERVQRKLS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPT_CUPMC
Sequence: MSKLKELPLSALQFYATAPYACSYLEGRMARSQVATPAHLINADVYSRLVRAGFRRSGIFTYRPYCDECRACTPCRVLVDQFRPDRSQRRAWRDHQGLQALVAPLTYVEEHYALYLLYQSMRHAGGGMDQDSRDQYEQFLLQSRVNSRLVEFREPPGSPEAGRLRMVSMIDVLDDGLSSVYTFYDPLIVGASYGTYNILWQINQTRELGLPHLYLGYWIADSRKMAYKARFQPLQVLTGNQWHTFKAPAEASGQPAPDPALE
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_RHIEC
Sequence: MPKMKTKSAAKKRFKITASGKVKAAAAGKRHGMIKRTNKFIRDARGTMVLAEPDGRKVVKNYLPNGL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: DAPD_UNKP
Sequence: MQQLQNVIESAFERRADITPANVDTVTREAVNQVIGLLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNKVMDGAETRYYDKVPMKFADYDEARFQKEGFRVVPPATVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYLGQSTRIYDRETGEIHYGRVPAGSVVVSGNLPSKDGSYSLYCAVIVKKVDAKTRGKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_MICDP
Sequence: MTKTYLPPQDALEREWYIVDATDQRLGRLASEIAMVLRGKKKAEYTPHLDTGDFVIVINAEKIAVTGKKRTQKLYRRHSGRPGGMKTETFAKLQQRIPERIVEHAVKGMLPKNSLGKQLFTKLKVYAGPTHPHAAQKPKELKVNTIPGAES
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: HTRA2_DROSI
Sequence: MALRGCHRLEVIFKRCIASPVLHSQAGNRRSSQLAIKGVDPNSNGNSGQYQQNGEHKEKGWRRLVRFFVPFSLGAAVSAAIIQREDFTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPNNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPEDP
What is the function of this protein?
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein.  Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism.  Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
What are the official names of this protein?
Serine protease HTRA2, mitochondrial, High temperature requirement protein A2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment. The extramitochondrial protein does not diffuse throughout the cytosol but stays near the mitochondria.
Protein: TBRG1_HUMAN
Sequence: MSLLDGLASSPRAPLQSSKARMKKLPKKSQNEKYRLKYLRLRKAAKATVFENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGEVQAAAPSHSSSLPLTYGVASSVGTIQGAGPISGPSTGAEEPFGKKTKKEKKEKGKENNKLEVLKKTCKKKKMAGGARKLVQPIALDPSGRPVFPIGLGGLTVYSLGEIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQIKDGGVQPQFEIVPEDDPQNAIVSSSADACHAELLRTISTTMGKLMPNLLPAGADFFGFSHPAIHNLIQSCPGARKCINYQWVKFDVCKPGDGQLPEGLPENDAAMSFEAFQRQIFDEDQNDPLLPGSLDLPELQPAAFVSSYQPMYLTHEPLVDTHLQHLKSPSQGSPIQSSD
What is the function of this protein?
Acts as a growth inhibitor.  Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis.  Redistributes CDKN2A into the nucleoplasm.  Involved in maintaining chromosomal stability.
What are the official names of this protein?
Transforming growth factor beta regulator 1, Nuclear interactor of ARF and Mdm2.
What is the protein family that this protein belongs to?
Belongs to the TBRG1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PPR84_ARATH
Sequence: MKRLKLILRRTYLTSTGVNCSFEISRLSRIGKINEARKFFDSLQFKAIGSWNSIVSGYFSNGLPKEARQLFDEMSERNVVSWNGLVSGYIKNRMIVEARNVFELMPERNVVSWTAMVKGYMQEGMVGEAESLFWRMPERNEVSWTVMFGGLIDDGRIDKARKLYDMMPVKDVVASTNMIGGLCREGRVDEARLIFDEMRERNVVTWTTMITGYRQNNRVDVARKLFEVMPEKTEVSWTSMLLGYTLSGRIEDAEEFFEVMPMKPVIACNAMIVGFGEVGEISKARRVFDLMEDRDNATWRGMIKAYERKGFELEALDLFAQMQKQGVRPSFPSLISILSVCATLASLQYGRQVHAHLVRCQFDDDVYVASVLMTMYVKCGELVKAKLVFDRFSSKDIIMWNSIISGYASHGLGEEALKIFHEMPSSGTMPNKVTLIAILTACSYAGKLEEGLEIFESMESKFCVTPTVEHYSCTVDMLGRAGQVDKAMELIESMTIKPDATVWGALLGACKTHSRLDLAEVAAKKLFENEPDNAGTYVLLSSINASRSKWGDVAVVRKNMRTNNVSKFPGCSWIEVGKKVHMFTRGGIKNHPEQAMILMMLEKTDGLLREAGYSPDCSHVLHDVDEEEKVDSLSRHSERLAVAYGLLKLPEGVPIRVMKNLRVCGDCHAAIKLISKVTEREIILRDANRFHHFNNGECSCRDYW
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g56690, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NUON_FLAJ1
Sequence: MNTLIAITGLGIFCLLFEILNFRKGIVPFTILGLLGVLALNFYEFGTTASYYNNMITVSKFSTAFSSLFIILTIFLVALSHNFYENHQTKISDFIAIKVFLLAGAVAMVSFGNLAMFFLGIEILSIALYVLAASDRLNIKSNEAGMKYFLMGSFASGIILFGICLIYGAMGTFDIAEIHESSLSAELPIWFPIGMILMTIGMFFKIAAVPFHFWAPDVYEGSPALTTALMSTLAKVVAIATLFKLVSGLNLIPSLENQDLSNTFTNVILTISIASMTVGNIMALRQVNVKRMLAFSGISHAGFMLMTFLTIATSAGVLLYYTAAYALAGIAAFSVILYVCKNQDNEDITNFHGLGKTNPLLAAILTGSLLSMGGIPIFSGFFAKLFLFNQALHAGYVAIVIAAVINSIISVGYYFKLILAMYSKEPNEERTGKPFLIYAVAIISIGLNIALGLFPSLVLDLLN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPF_GEOSW
Sequence: MFRIGQGFDVHQLVEGRPLIIGGVRIPYEKGLLGHSDADVLLHAVADACLGAIGAGDIGKHFPDTDECYKDADSALLLKQVWELVKQQGYELANLDCTIIAQKPKMAPHIEQMKENIANLLEGELSQVNVKATTTEKLGFTGREEGIAAQAVVLLQKK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: CPNE2_HUMAN
Sequence: MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAGKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA
What is the function of this protein?
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes.  Exhibits calcium-dependent cell membrane binding properties.
What are the official names of this protein?
Copine-2, Copine II.
What is the protein family that this protein belongs to?
Belongs to the copine family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane. Note=Translocates to the cell membrane and the nucleus in a calcium-dependent manner. Colocalizes with CD2 at the cell membrane.