PharMolix/UniProtQA huggingface dataset:
Protein: HRCA_ENTFA
Sequence: MITERQQNILRLIIQNYTNTGLPVGSKKLMEDGIASSSATIRNDMKALEEYGLLAKTHSSSGRIPSMAGYRYYVDHLLQPTQVEENELRRIRQSFGKEFHEINDIIRQSAEILSELTSYTAFSLGPEVKERKLTGFRMVPLNDRQVLAIIVTDKGNVENQVFAIPAAVSSQDLEKMTQIINDKLVGQPLLTVYHRLRTEIPMILHRYFQTPEGMMNLFDEMLGHAFEEKVFVGGRMNLLDFGIKQDIEQLKSVYSFMQNSDELTHLLNGSATTENPIVFRIGSEIGNNLLEDMSMITATYEVSGHGKGTIALLGPTSMPYSKIFGLVDTFRHELASQLGDYYRFLGN
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: PSAB_CYCTA
Sequence: MASRFPKFSQGLAQDPTTRRIWFGIATAHDFESHDDITEERLYQKIFASHFGQLAIIFLWTSGNLFHVAWQGNFEAWVRDPLHVRPIAHAIWDLHFGQPAVEAFTRGGAPGPVNIAHSGVYQWWYTIGLRTNEDLYTGALFLLFLSAISLIAGRFHLQPKWKPSVSWFKNAESRLDHHLSGLFGVSSLAWTGHLVHVAIPESRGEHVRWDNFLDVLPYPRGLGPLFTGQWNLYAQNPDSSSHLFGTSQGAGTAILTLLGGFHPQTQSLWLTDIAHHHLAIAFVFFIAGHMYRTNFGIGHSIKDILEAHIPPGGLLGRGHKGLYNTINNSLHFQLGLALASLGVITSLVAQHMYSLPAYAFIAQDFTTQAALYTHHQYIAGFIMTGAFAHGAIFFIRDYNPEQNRDNVLARMLEHKEAIISHLSWASLFLGFHTLGLYVHNDVMLAFGTPEKQILIEPIFAQWIQSAHGKALYGFDVLLSSTNSPAFNAGQSIWLPGWLNAINDNSNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWVTFYWHWKHITLWQGNVAQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLSVWAWMFLFGHLVWATGFMFLISWRGYWQELIETLAWAHERTPLANSVRWRDKPVALSIVQARLVGLAHFSVGYIFTYAAFLIASTSGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: TNNC2_ASTLP
Sequence: MDTLDEEQLSALKKAFDSFDTDSKGFITPETVGVILRMMGVKISEKNLQQVIAETDEDGSGELEFEEFVELAAKFLIEEDEEALKAELKEAFRIYDKGGDGYITTDVLREILRELDNRLTEDDLDGIIEEVDEDGSGTLDFDEFMEMMSG
What is the function of this protein?
Troponin is the central regulatory protein of striated muscle contraction.  Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.  The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
What are the official names of this protein?
Troponin C, isotype gamma.
What is the protein family that this protein belongs to?
Belongs to the troponin C family.
Protein: RNH2_POLAQ
Sequence: MNMIWVCGVDEAGRGPLVGAVVAGAVVLDPENPIEGLKDSKKLSAVRREFLYEQIMEKAKAWGVGEASPTEIDSINILQATMLAMRRAVEDLAARLGEWPSKALIDGNRCPELSIAAEAIVKGDTKEPAISAASIVAKVTRDRQMIALHEQHPQYGFSQHMGYPTEAHFAALKQYGVCTEHRKSFAPVRRVLEGSF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_BREMA
Sequence: MSPQTETKASVGFKAGVKDYKLNYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEENQYIPYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEALYKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHVHAGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEVWKEIKFEF
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CADH2_CHICK
Sequence: MCRIAGTPPRILPPLALMLLAALQQAPIKATCEDMLCKMGFPEDVHSAVVSRSVHGGQPLLNVRFQSCDENRKIYFGSSEPEDFRVGEDGVVYAERSFQLSAEPTEFVVSARDKETQEEWQMKVKLTPEPAFTGASEKDQKKIEDIIFPWQQYKDSSHLKRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKSLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIASFHLRAHAVDVNGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNAQNGMLRYRILSQAPSSPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNARYQMTGGDPTGQFTILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSITVIDVNESPYFVPNPKLVRQEEGLLAGSMLTTFTARDPDRYMQQTSLRYSKLSDPANWLKIDPVNGQITTTAVLDRESIYVQNNMYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVNPKEATTCETLQPNAINITAVDPDIDPNAGPFAFELPDSPPSIKRNWTIVRISGDHAQLSLRIRFLEAGIYDVPIVITDSGNPHASSTSVLKVKVCQCDINGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD
What is the function of this protein?
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (PubMed:2831236).  Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).  Required for proper neurite branching, and pre- and postsynaptic organization (PubMed:29760652).
What are the official names of this protein?
Cadherin-2, Neural cadherin, N-cadherin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma. Cell junction. Cell surface.
Protein: BETI_YERPA
Sequence: MPKVGMQPIRRQQLIEATMAAVNEVGMHEASIAQIAKRAGVSNGIISHYFRDKNGLLEATMRYLIRHLGEAVKQHLAALSVNDPRARLRAIAEGNFDDSQINSAAMKTWLAFWASSMHSPQLYRLQQVNNRRLYSNLCAEFKRCLPREQAQLAAKGMAGLIDGLWLRSALSGEHFNRQEALLIIHNYIEQQLNIKYKC
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: TRMH_THET8
Sequence: MRERTEARRRRIEEVLRRRQPDLTVLLENVHKPHNLSAILRTCDAVGVLEAHAVNPTGGVPTFNETSGGSHKWVYLRVHPDLHEAFRFLKERGFTVYATALREDARDFREVDYTKPTAVLFGAEKWGVSEEALALADGAIKIPMLGMVQSLNVSVAAAVILFEAQRQRLKAGLYDRPRLDPELYQKVLADWLRK
What is the function of this protein?
Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.  Type I methylase, which methylates all tRNAs.
What are the official names of this protein?
tRNA (guanosine(18)-2'-O)-methyltransferase, tRNA [Gm18] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: MRAZ_HAMD5
Sequence: MFRGATMLSLDNKGRLVIPVRYRDILKEKSQSRMICTIDLHQTCLLLYPFLEWESIEKKLSDLSSMNPLERRVQRLLLGHASECEMDKSGRLLISATLRQHAQLSKEVMLIGQLNKFEIWSGPNWQQQIKDDITSKQPVQESLSERLKGLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: HBL_HORVU
Sequence: MSAAEGAVVFSEEKEALVLKSWAIMKKDSANLGLRFFLKIFEIAPSARQMFPFLRDSDVPLETNPKLKTHAVSVFVMTCEAAAQLRKAGKITVRETTLKRLGGTHLKYGVADGHFEVTRFALLETIKEALPADMWGPEMRNAWGEAYDQLVAAIKQEMKPAE
What is the function of this protein?
May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule.
What are the official names of this protein?
Non-symbiotic hemoglobin, HORvu GLB1, Non-legume hemoglobin.
What is the protein family that this protein belongs to?
Belongs to the plant globin family.
Protein: UBIB_XANC8
Sequence: MKAILRASRIGRVILRYRLDALLEGTPAERWLRLAKPFVPRASAEIAAQSRGARLRLALQELGPIFVKFGQILSTRRDLIPPDVAEELTLLQDRVKPFDGEAARLIVERALGLPVSVAFAAFDTTPLASASIAQVHAATLPPDANGLRREVVVKVLRPDIERQIDADIALLHSLATLVERTHPRADKIRPREVVAEIEGTLSAELDLQREGANASVLRRFWEGSDDLYVPEVIWSHTAERALTLERVYGIPSDDVAKLDAAGIDRKALAAKGVRVFYTQVFRDNFFHADAHAGNIWVDSDPERRLNPRFIALDFGIMGQLSQEDQYYLAENFMAIFHKDYRRMAELHVEAGWMPSNVRIDELEAAARSVCEPYFTRPLSEISLAEVLIKLFRVAQRYELTLQPQLILLQKTLLNIEGVGRQLDPKLDIWAVARPVLERILRERYSPRRVLGELRKRLPEIMTHAPDMPRLVHSWLKQQVEGRHQLDIRSSELRALDLSLRKLQTRVVTAITGSGLLVVAAVLYGLHPDGWYLGTVPVWSWISGGAGSAALLIAWLRR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HLDE_SALPA
Sequence: MKVNLPAFERAGVMVVGDVMLDRYWYGPTCRISPEAPVPVVKVNTVEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKTLAEVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALGSIGALVLSDYAKGALTSVQTMISLARQAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVAGKCKSEDELVERGMKLIADYDLSALLVTRSEQGMTLLQPNKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNTLEEACYFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELRQAVASARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGESRPVNPLEQRMIVLGALESVDWIVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSEEVWANGGEVMVLNFEDGCSTTNIIKKIQTESEK
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: SPY_DROME
Sequence: MDRRNGGDPLAPPRPPKLLPRVHRPRAPEPTLSGVDHNAGATASALASGASSAAPVAIHNNNSQQQLSISAAASNNNTISIIPASPDFDDYQIHHLTFLPQRPSSLSRNSSTASSTTATGISVSGSGSVSGSSSSFTRRRPPAPVPLNNSISNNNNNSINNNFLSHFQSAEPASNALGQPPASPVTLAQPRPESERLTNEYVDTPLQHATRSQHPAGQQDNGQTTTHHLLLLPQRNQHLHLQQHQQHLQQQQQQQQQQQQQQHLQHQQNQQHARLATTTQATSVGSDHTDGLLHSHLQNSTTKPPASKQPAPPRLGMGLGLGLGLGLNQPIITKQPTPATQKERMHALEELLQPGGAGGNGGPLVMAGDPSLLNPIVCPRCGRCRCEQCQSPRPLPQTWVCNKTCLCSAESVIDYASCLCCAKALFYHCARDNDLDCDDGNGTPCVDNPCSCGPYKRTQRWGWLGALSIFLPCLWFYWPMRGCMKLCEKCYGRFAGRGCRCQGIGGGGAGSGGGVGSIGSTSSMLPIVPLGVNGSGLGGGVSLSGGVTDGGLNQANGKAMDHGCSAARSILRKGDLTPEKRLLDSSPDY
What is the function of this protein?
Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL: branchless, an fgf inducer of branching).  Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells.
What are the official names of this protein?
Protein sprouty, Spry.
What is the protein family that this protein belongs to?
Belongs to the sprouty family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SAR1B_MOUSE
Sequence: MSFIFDWIYSGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMTDETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSVSLKELNARPLEVFMCSVLKRQGYGEGFRWMAQYID
What is the function of this protein?
GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus.  Activated by the guanine nucleotide exchange factor PREB.  Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity).  Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (By similarity).
What are the official names of this protein?
GTP-binding protein SAR1b.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. SAR1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.
Protein: RNH_HAEIG
Sequence: MQKQIEIFTDGSCLGNPGAGGIGAVLRYKQHEKMLSKGYFKTTNNRMELRAVIEALNTLKEPCLITLYSDSQYMKNGITKWIFNWKKNNWKASSGKPVKNQDLWIALDESIQRHKINWQWVKGHAGHRENEICDELAKKGAENPTLEDMGYIEE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_CNV
Sequence: MDTIKRMLWPKKEIFVGTFATGVERDTSVDIFQLVCRVVLRYMRTGKIENNTDSLGNFIVELLKTDCAAKWEWFMKRRRVGDYAKSLAIASIPVIPLLSYATMKKTVALRAFGNELSFNIRVPRPSVPKKGLLLRLAAGLALAPICALAMYATLPREKLSVFKLRTEARAHMEDEREATDCLVVEPARELKGKDGEDLLTGSRMTKVIASTGRPRRRPYAAKIAQVARAKVGYLKNTPENRLIYQRVMIEIMDKDCVRYVDRDVILPLAIGCCFVYPDGVEESAALWGSDESLGVKXGGLVRLPGVVTQTNRDIPSGVLLPQEVLEVRAGPPNAKDRNIFMVAGCPSQARFLVHNHCLKNLKRGLVERVFCVERNGQLTRTPQPTKGAFGRLSPFRKAVCEKVGVAHRLGYDGFLSYYSGAKLRTYTRAVESLHITPVSERDSHLTTFVKAEKISTAKGDPAPRVIQPRNPRYNVELGRYLRHMESKLMKAVDGVFGETTCIKGYTADEVGQIFRDKWDRFNKPVAIGLDASRFDQHCSVEALQFEHGFYRAMYPGNKLLSKLLDWQLHNKGKGYVPDGTITYRKEGCRMSGDINTSLGNYLLMCAMIYGYMRHLGINEYSLANCGDDCVLIVERRNLKQIQGTLPEYFLNLGYTMKVEPPVFQLEEVEFCQAHPVQFQGGWKMVRNVRTAMSKDVHCVNNIRDLATRRAWSNAQHHGGVALTSGIPVVEKFYSRFTLYEVPKKHQRIDTVTNVHKWRGSGGDYVVTPEARASFWAAFGLTGDEQLALEDRLDRWEMDLFGEEGVDAHEPSILDSAVA
What is the function of this protein?
RNA-dependent RNA polymerase that plays an essential role in the virus replication.
What are the official names of this protein?
RNA-directed RNA polymerase, Protein p92.
What is the protein family that this protein belongs to?
Belongs to the tombusviridae RNA polymerase family.
Protein: RECR_LACGA
Sequence: MQYPLPIARLIDNYMKLPGIGEKTATRLAFYTMDMPEDDVEDFSKSLIQVKENLHSCSICGNITESDPCEICRDANRDRSTIMVVEQPKDVMAFEEMGEYNGLYHVLHGVLSPMDGVGPEEINIKSLITRLQKQDEVKEVILALNSSPEGEATAMYLAKLIKPAGLKVTRLAAGLAVGSDIEYANSITLKRAVQGRTDL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: NRDR_BRUSU
Sequence: MRCPYCQSEDTQVKDSRPAEDGAVIRRRRVCSVCGGRFTTFERVQLRDLMVVKKSGRRVPFDRDKLTRSIEVALRKRDVDSERVERAISGIVRQLESAGEAEVTSDEIGRLAMDALKGIDDIAYIRFASVYRNFSKAVDFHNVIDELTVSETGDNLET
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: HBB_HEMAK
Sequence: MVKLSEDQEHYIKGVWKDVDHKQITAKALERVFVVYPWTTRLFSKLQGLFSANDIGVQQHADKVQRALGEAIDDLKKVEINFQNLSGKHQEIGVDTQNFKLLGQTFMVELALHYKKTFRPKEHAAAYKFFRLVAEALSSNYH
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CUTC_YERPA
Sequence: MTKLEVCCYSVDCAQIAEKAGADRVELCCGQSEGGVTPSVGALMQARETVTIPVHPIVRPRGGDFCYSSNDFTIMKNDIARIRDLGFAGVVVGVLDTDGHIDMPRMREIMSVSGSLAVTFHRAFDMCQNPMIALKQLAELNVARILTSGQQQNAELGLALLKDLVAATKDQGPIIMAGAGVRLTNMQKFIDAGIRELHSSAGRTVPSTMRYRKAGVTMCADSDVDEFSHYCVDGEVVEAMKSLLVMGSPLAKHT
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADHA_GLUOX
Sequence: MTSGLLTPIKVTKKRLLSCAAALAFSAAVPVAFAQEDTGTAITSSDNGGHPGDWLSYGRSYSEQRYSPLDQINTENVGKLKLAWHYDLDTNRGQEGTPLIVNGVMYATTNWSKMKALDAATGKLLWSYDPKVPGNIADRGCCDTVSRGAAYWNGKVYFGTFDGRLIALDAKTGKLVWSVYTIPKEAQLGHQRSYTVDGAPRIAKGKVLIGNGGAEFGARGFVSAFDAETGKLDWRFFTVPNPENKPDGAASDDILMSKAYPTWGKNGAWKQQGGGGTVWDSLVYDPVTDLVYLGVGNGSPWNYKFRSEGKGDNLFLGSIVAINPDTGKYVWHFQETPMDEWDYTSVQQIMTLDMPVNGEMRHVIVHAPKNGFFYIIDAKTGKFITGKPYTYENWANGLDPVTGRPNYVPDALWTLTGKPWLGIPGELGGHNFAAMAYSPKTKLVYIPAQQIPLLYDGQKGGFKAYHDAWNLGLDMNKIGLFDDNDPEHVAAKKDFLKVLKGWTVAWDPEKMAPAFTINHKGPWNGGLLATAGNVIFQGLANGEFHAYDATNGNDLYSFPAQSAIIAPPVTYTANGKQYVAVEVGWGGIYPFLYGGVARTSGWTVNHSRVIAFSLDGKDSLPPKNELGFTPVKPVPTYDEARQKDGYFMYQTFCSACHGDNAISGGVLPDLRWSGAPRGRESFYKLVGRGALTAYGMDRFDTSMTPEQIEDIRNFIVKRANESYDDEVKARENSTGVPNDQFLNVPQSTADVPTADHP
What is the function of this protein?
Dehydrogenase component of the alcohol dehydrogenase multicomponent enzyme system which is involved in the production of acetic acid and in the ethanol oxidase respiratory chain.  Quinohemoprotein alcohol dehydrogenase (ADH) catalyzes the oxidation of ethanol to acetaldehyde by transferring electrons to the ubiquinone embedded in the membrane phospholipids (PubMed:1646200, PubMed:7592433, PubMed:8617755, PubMed:9878716, PubMed:18838797).  The electrons transfer from ethanol to membranous ubiquinone occurs from pyrroloquinoline quinone (PQQ) to one heme c in subunit I (AdhA), and finally to two heme c in subunit II (AdhB) (PubMed:8617755, PubMed:9878716, PubMed:18838797).  Besides ubiquinone reduction, ADH also has a ubiquinol (QH2) oxidation reaction which mediates electron transfer from ubiquinol to the non-energy generating bypass oxidase system (PubMed:9878716).  The electrons transfer occurs from ubiquinol (QH2) to the additional heme c within subunit II (AdhB) (PubMed:8617755, PubMed:9878716).  Also able to use quinone analogs such as 2,3-dimethoxy-5-methyl-6-n-decyl-1,4-benzoquinone (DB) and 2,3-dimethoxy-5-methyl-6-n-pentyl-1,4-benzoquinone (PB) (PubMed:9878716).
What are the official names of this protein?
Alcohol dehydrogenase (quinone), dehydrogenase subunit, ADH, Alcohol dehydrogenase (quinone), acceptor subunit, Alcohol dehydrogenase (quinone), subunit I, Ethanol:Q2 reductase, G3-ADH subunit I, Quinohemoprotein alcohol dehydrogenase, Quinohemoprotein-cytochrome c complex, Ubiquinol oxidase.
What is the protein family that this protein belongs to?
Belongs to the bacterial PQQ dehydrogenase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Periplasmic side.
Protein: COBT_VIBPA
Sequence: MDCSFSADIQTRIDNKTKPLGALGVLEKVALQLALIQSQDQAQAVEEIVIRKPTMLVFAGDHGVAKEGISIAPSEVTQQMVANFLAGGAAINCFCDVNQIEFKVIDCGMLAPIEVMVPEFKSHPNLIEQRLGNGTANFSKQAAMSSEQVALGLEYGARVAQSTIYSGSNLLMFGEMGIGNTSSASALLAALSPLEVNHCVGLGTGINSEQLSRKLKLVAQGVSRCRGLDAKAVLSQVGGFEIVQMVGAFLEAKRLKTPVLVDGFIVSVAAYVATLLDEETRDYMLFAHRSEENGHKFVLESLKAEPLLDLGLRLGEGTGAALALPLLKAAAQFYNKMASFESAGVTV
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: YOAH_ECO7I
Sequence: MFAGLPSLTHEQQQKAVERIQELMAQGMSSGQAIALVAEELRANHSGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: METXA_LEPBP
Sequence: MPTSEPNDFFHGSVGIVQTQVATFDSLTLEGGETITPLEIAYETYGTLNQKKDNAILVCHALSGDAHAAGFHEGDKRPGWWDYYIGPGKAFDTNRYFIISSNVIGGCKGSSGPLSTNGNTGKPFQSTFPFVSIGDMVNAQEKLIRHFGIHKLFAVAGGSMGGMQALQWSVAYPDRLKNCIVMASSSEHSAQQIAFNEVGRQAILSDPNWNQGLYTQEKRPSKGLALARMMGHITYLSDEMMREKFGRKPPKGNIQSTDFAVGSYLIYQGESFVDRFDANSYIYVTKALDHFSLGTGKELTKVLSKVRCRFLVIAYTSDWLYPPYQSEEIVKSLEVNAVPVSFIELNNPAGHDSFLLPSEEQDSILRDFLSATDEGGFF
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBX7_BOVIN
Sequence: MKLRVRLQKRTWPLDMPEVEPTLGQLRAYLSQALPTWGYSSDARFAITLNNKDALTGDEETLASYGIVSGDLLCLILEDAIAAPNLPSSTVSEHSSVQNNDQPSLATSSSQSNIQDAQLHDSLQGQATQSEVWNDDSVSGPGQHFEAEAVPDVVDVEEGTGYYLAEPMLCSESVEGQVPHSLEILYQSADCLNPCDALIVSIHLLMLESGYIPQGTEAKAVSMPQNWRLGGVYKLQYTHPLCEGGSAALTCVPLGNLIVINATLKINSEVRSVKRLQLLPESFICKEESGENVAMIYKDLQKLSRLFKDQLVYPLLAFTRQALNLPDVFGLVVLPLELKLRIFRLLDVRSVLSLSAVCRDLCITSNDQLLWRCLYLRDFRDGSIRGRDTDWKELYKKRYKQRKEAQRGRHVMFLPSSPHPIPFYPSPLHPRPFPPSSLHPPGIIGGEYDQRLTLPYVGDPINSLIPGPGETPSQFPPLRPRFDPVGPLPGPNPILPGRGGPSDRFPLRPSRGWPTDSRLPFM
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability.  Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5.  Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria.  Promotes MFN1 ubiquitination.  Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway.  Inhibits NF-kappa-B pathway also by promoting the ubiquitinatioin of TRAF2 (By similarity).  Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (By similarity).  Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (By similarity).
What are the official names of this protein?
F-box only protein 7.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytosol. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria (By similarity).
Protein: CMOA_CAMJR
Sequence: MKDELFKQSPKKQFEFDKSVASVFDDMINRSVPFYRENLELCGNLLAKILPTNASVCDLGCSSANFLIFLANLRKDFKLFGVDNSASMLEVAKSKAKAYGLDISFFEANLCEFDFFTCDVFVANYTMQFIRPPKRQELLDQIYKNLNSKGILIMSEKILYEDAFLSKNIIELYADYKEKQGYSKFEIAAKREALENVLIPYSQKENLNMLEKAGFKKIESIFKWANFETFIAFKD
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.