PharMolix/UniProtQA huggingface dataset:
Protein: AROA_BUCAP
Sequence: MQKFLELKPVSYINGTIYLPGSKSISNRVLLLSAMANGITCLTNLLDSQDTQYMLNALRKIGIKFFLSNNNTTCHVHGIGKAFHLSHPISLFLGNAGTAMRPLLAALSLYENNVVLSGDDRMHERPIAHLVDALKQGGATLEYKKGIGYPPVLTKGGFKGGSIMLDGSISSQFLTSLLMVAPLALQNTNIFIKGNLVSKPYIDITLNLMKSFGVNIVNDCYKSFYIKGNQKYESPGNYLVEGDASSASYFLAAAAIKGGSVKVVGVGKKSVQGDIKFADVLEKMGAIIDWGDSFIVCRHNKLEKIDLDMNHIPDAAMTIAIVALFAKGTSIIKNIYNWRVKETDRLSAMSKELKKVGAIIKEGRDCLSITPPNFFKFAEIDTYNDHRMAMCFSLICLSGISVRILNPNCISKTFPSYFENFLKISRFD
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A4_CAEEL
Sequence: MTVGKLMIGLLIPILVATVYAEGSPAGSKRHEKFIPMVAFSCGYRNQYMTEEGSWKTDDERYATCFSGKLDILKYCRKAYPSMNITNIVEYSHEVSISDWCREEGSPCKWTHSVRPYHCIDGEFHSEALQVPHDCQFSHVNSRDQCNDYQHWKDEAGKQCKTKKSKGNKDMIVRSFAVLEPCALDMFTGVEFVCCPNDQTNKTDVQKTKEDEDDDDDEDDAYEDDYSEESDEKDEEEPSSQDPYFKIANWTNEHDDFKKAEMRMDEKHRKKVDKVMKEWGDLETRYNEQKAKDPKGAEKFKSQMNARFQKTVSSLEEEHKRMRKEIEAVHEERVQAMLNEKKRDATHDYRQALATHVNKPNKHSVLQSLKAYIRAEEKDRMHTLNRYRHLLKADSKEAAAYKPTVIHRLRYIDLRINGTLAMLRDFPDLEKYVRPIAVTYWKDYRDEVSPDISVEDSELTPIIHDDEFSKNAKLDVKAPTTTAKPVKETDNAKVLPTEASDSEEEADEYYEDEDDEQVKKTPDMKKKVKVVDIKPKEIKVTIEEEKKAPKLVETSVQTDDEDDDEDSSSSTSSESDEDEDKNIKELRVDIEPIIDEPASFYRHDKLIQSPEVERSASSVFQPYVLASAMFITAICIIAFAITNARRRRAMRGFIEVDVYTPEERHVAGMQVNGYENPTYSFFDSKA
What is the function of this protein?
Required for normal developmental progression throughout all life stages (PubMed:18262516, PubMed:22466039).  Specifically required for the molt stage during all larval transitions and morphogenesis (PubMed:18262516, PubMed:17267616, PubMed:22466039).  Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition (PubMed:18262516, PubMed:28933985).  Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells (PubMed:28933985).  Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg-laying (PubMed:22466039).  May play a role in neurotransmission (PubMed:20862215).
What are the official names of this protein?
Amyloid-beta-like protein.
What is the protein family that this protein belongs to?
Belongs to the APP family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Early endosome.
Protein: ILVC_MYCA1
Sequence: MFYDDDADLTIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVKVGLKEGSKSRAKVSEQGLDVDTPAAVAKWADVIMLLAPDTAQADIFKNDIEPNLSDGDALFFGHGLNIHFGLIKPPAEVTVAMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTGKGEALALSYAKAIGGTRAGVIKTTFKDETETDLFGEQAVLCGGTEELVKAGFDVMVEAGYPPEMAYFEVLHELKLIVDLMYEGGIARMNYSVSDTAEFGGYLSGPRVIDAGTKDRMREILRDIQNGDFVKKLVANVEGGNKQLEQLRKENAEHPIEVVGKRLRDLMSWVDRPITETA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ELP2_SCHPO
Sequence: MFQYEALHVGCNRIPTAATWSSNLGLIYGAERLIAVADPFKEINYLMAGHSGRINCVCELATNSEYRSPFILSGASDKTLRLWQLEEEYFTCIKTIELEATVNCLCVNENLVVCGCSNSSCIVYSWNAEQRNLTEISRFTCSEIIPLEFAIVKLDHGIILTVCGSSKKIMVYGSDSAISSFKLKAVLRGHLDWVRTLSFKKTSGSTATLASGSQDRYIRLWNISLWGSEDEKVSEEFFESVLSNKPVRFTLGKIDLKIVFDALLMGHEDWVMSVDWHPTKEMILSSSADSSMIVWEPDTNTGIWVVTGRMGEMASSHGSTTATGSAGGFWGGLWNPNGNCVVCWGRTGGWRLWKQDAGQWLQLPSISGHTKSVKGVAWDPEGKFYLSAGTDQTTRLFARFKKDNAWHEMARPQIHGYDLTSISCMPSRIGFLSCADEKVSRVFKFPKTIVRLLYRLCDTNIGEESLPDAANVPLLGLSNKATTASETGTVNAEEVQTPVADVIGSLNHPPFEEHLQRLLLFPEVEKLFGHGYEVYACAISNNGNIAATSCKSQTPEHAVIRLYETQSWNQQQVLKGHSLTVTTIKFSPDDRYILSAGRDRLVCLHEQAENLLDYNNFASIKAHSRIIWDASWAPKEMGYFFATASRDKFVKFWKINDNKKICDVAALQFSDAVTAVDFAPFFHNDELLLAVGTEAGKIFIWRCPRENLTKWYPTRLPDHMAPMESINQILWKPTFETMGLYSLLIAGEDTSVRLLNVTLG
What is the function of this protein?
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244).  The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244).
What are the official names of this protein?
Elongator complex protein 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ELP2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DAPE_PASMU
Sequence: MKNSIIELARELIRRPSISPDDQGCQQIIAERLERLGFQIEWLPFNDTLNLWAKHGSGSPVIAFAGHTDVVPVGDTTQWQYPPFSAQLVDNVLYGRGAADMKGSLAAMVVAAEHYVKANPEHSGTVALLITSDEEAAAKDGTVRVVETLMARGEPIDYCIVGEPSSAQQFGDIVKNGRRGSITANLYIQGIQGHVAYPHLAQNPVHKALGFLTELTTYQWDNGNDFFPPTSLQIANIQAGTGSNNVIPGELYVQFNLRYCTEVTDDIIKKKVAEMLAKHQLNYRIEWHLSGKPFLTAKGKLVDTLLDVVEKITQNRPHLDTGGGTSDARFIALMGAEVVEFGPLNKTIHKVDECVNVDDLAKCGEVYQHVLCNMLERV
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: AB9I_ARATH
Sequence: MASLFAIGFSKFSPQPTSDYSKLLKVFHPKPYSLKFLFLKTLNPTRFFKVRANDGTEPSDKLQQYFQNQDYDKKYGFLENIDSFTIPKGLSEETIRLISKLKKEPAWILEYRLKAYAKFLKLEEPKWSDNRYPLLDLQDMCFYSAPKKKPTLNSSDIADEADDPKLLEEFDRLDVPLTKKKKCSPKVAVDAVYNSESIAITNKEPLEKSGVIFCSISEAIRKYPDLIKKYLGRVVPSDDNYYAALNTAVFSDGSFCYIPKNTRCPMPLSSYFRMNSIENTGQFERTLIVAEEGSFVEYSEGCTAISHDKNQLHAAVVELYCAEGAEIKYSTRGLCAGDRSKISWTQVEKGFAITWKYPSVVLEGDDSVGEAENARNTSTCDSMLIGDNAAANTYPYIQVKNPSARIEHEASTSKIGEDQIFYFQQRGIDHERALAAMISGFCRDVFNKLPNEFGAEVNQLLSIKLEGSVG
What are the official names of this protein?
Putative UPF0051 protein ABCI9, ABC transporter I family member 9, ABC transporter ABCI.9, AtABCI9.
What is the protein family that this protein belongs to?
Belongs to the UPF0051 (ycf24) family.
Protein: AROB_BACCQ
Sequence: MENIHIQTKSKEYDVHVGKESLSHLTTIVQNMQPSVSNIMIISDEAVAPLHLQTVVDALQIDQKVFSFVVPSGEKEKSFENFYAAHTSALENKLDRNSLIIALGGGMIGDLAGFVAASFMRGIRFVQVPTTLLAHDSAVGGKVAINHPLGKNMIGAFHQPEAVVYHTPFLQSLPEKEWRSGYAEVIKHALIGDVKLYHWLKEEVQTLADLRDEKLIHILTKAIPVKANIVAQDETEKGVRAHLNFGHTLGHALEKELGYGNITHGDGVAVGMLFAIFLSEQVYKVNLAYEEMKQWFLKYGYPKMPSDLSVERLVGLMKQDKKANAGTIHMVLMQEYGVVNVVSIPDETVHIALEAFQKDMGIRSR
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPP_SYNY3
Sequence: MNLAVPAFGLSTNWSGNGNGSNSEEESVLYQRLKMVEELWERVLQSECGQELVDLLTELRLQGTHEAITSEISEEVIMGITQRIEHLELNDAIRAARAFALYFQLINIVEQHYEQNEQQRNRWEASQETNFYEQAGNEEEMVPPSRLGASTEPLPVGIDQNELQASVGTFHWLMRELKRLNVPPQHIQNLLDHLDIRLVITAHPTEIVRHTIRRKQRRVDRILRKLDQLQGSVTGRDWLNTWDAKTAIAQLTEEIRFWWRTDELHQFKPTVLDEVDYSLHYFDEVLFDAVPELSKRLGQAIKETFPHLRAPRANFCYFGSWVGGDRDGNPSVTPEVTWQTACYQRGLVLGKYLFSLGELVAILSPSLHWCKVSQELLDSLERDRIQLPEIYEELSLRYRQEPYRMKLAYVTKRLENTLRRNNRLANPEERQTMITMPAENHYRTGEELLEELRLIQRNLTETGLTCLELENLITQLEVYGFNLAQLDFRQESSRHAEAIAEIAEYMGVLTTPYEEMAEEDKLAWLGVELQTRRPLIPQEMPFSERTRETIETLRTLRHLQMEFGVDICQTYIISMTNDASDVLEVLLLAKEAGLYDPATASNSLRIVPLFETVEDLKNAPGIMDSLFSLPFYRATLAGSYHSLKELQNQPPDYYQIPTTTALLNPGNLQEIMVGYSDSNKDSGFLSSNWEIHKAQKSLQAVAQSHRVILRLFHGRGGSVGRGGGPAYKAILAQPAGTVDGRIKITEQGEVLASKYSLPELALYNLETLTTAVIQASLLKSSFDFIEPWNRIMEELACTARRAYRSLIYEEPDFLDFFLTVTPIPEISELQISSRPARRKGGKADLSSLRAIPWVFSWTQTRFLLPAWYGVGTALKSFVDQDPVKNMKLLRYFYFKWPFFNMVISKVEMTLSKVDLTIASHYVQELSKPEDRERFDRLFQQIKQEYQLTRDFAMEITAHPHLLDGDRSLQRSVLLRNRTIVPLGLLQISLLKRLRQVTQEAETSGVRYRRYSKEELLRGALLTINGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: LPXA_CHLMU
Sequence: MTNIHPTAIVEDGAQIGNNVTIEPYAIVKKNVKLCDDVVVKSYAYIDGFTTIGRGTTIWPSAMIGNKPQDLKFKGEKTFVEIGEHCEIREFAMITSSTFEGTTVSIGNNCLIMPWAHIAHNCSVGNNVVFSTHVQLAGHVQVGDCVTIGSMVGVHQFVRIGSYAMVGAMSGIRRDIPPFTIGTGNPYALGGVNKVGLQRRRVPFETRLALIKTFKRVFRSGESFQDSLGSVLEDFGDVPEVRHFVEFCRQPSKRGIERGIDCEASLDEPIDKKEGAFVES
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUKB_ACTPJ
Sequence: MTDTNELFEDQTTALQNSAPIAPLANPQHTVSRGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAGFVTALIPDLTLLNFRNTTEAGSTSSSRDKGLYGKLKAGVCYAVLESLNSRGQRVITGVRLQQVAGRDKKVDIRSFSLQNVPMSDSIISVLTEQVGEKARVLPLADLKDKFDGSEVVFKQYHSITDYHSFMFDLGVIPKRLRSSADRSKFYKLIEASLYGGISSVITKSLRDYLLPENTGVRQAFQDMESALRENRMTLEAIKVTQSDRDMFKRLITESTNYVSADYMRNANERRGNVQIALEQRRAWYESKSKLELEQQRLIEFSREVADISENESSLEAEYNSANDHLNLVMNALRHQEKIERYQDEVAELNEKLEEQQIALEEVSEQVETAQARADDADDQVEELRSQMADYQQALDAQQTRALQYQQAIAALEKAKQLCGLPHLDLHNVEDYHAEFAAQADDLTDQVFELEQRLSVSDMAKTQFEKAYELVCKISGEIDRSEAWDEARSLLTAFTDQKMQATQAVALRQKLADLEQRLHQQQNAERLLAEFNQKAQTQFETAEELEGYFEQQQARLEDVEAELAEFVEVRSTQRQQREQLNQQYNQLAKTAPAWHTAQSALARLEEQCGEKFEASQSVMQFMQNMLTKEREATLARDKLARREAALDAQITRLSQPDGSDDVRLNQLAERFGGVLLSELYDDVSIDDAPYFSALYGEARHAIVVRDLESVKSQLEKLDDCPTDLYLIEGDPSAFDDAVFTAEELAEGVVVKVSDRQWRYSKFPEVPLFGRAAREKHLETLKAERDEVSEQHAERAFDVQKCQRLHQHLSQFVGTHLSLAFQPNPEEQMQEIAAERTEIERELNQAAGNEQQLRSQLDSAKAKLQMLNKILPLVSLLEDETLADRAEECRAQLDEAEEDEQFVRQFGNYLTQLEPIAASLKSDPAKFEQLEQDYRQAKAEQKQVQQKVFALSDVIQRRVHFSYEEAIGSEGSALTEQLRTRLENAQREREQARDQLRQAQAQFTQYNQVLTGLRSSCDAKTQMLQELIREIDDLGVRGDIGAEERARSRRDELQQRLSQQRSRKGYLDKQLGTIEAEIDNLTRTLRKAERDYHTQRELVVQAKVSWCLVLKLSRNSDVEKRLNRRELAYQSAEELRSISDKALGALRTAVADNEYLRDSLRASEDSRKPENKVAFFIAVYQHLRERIRQDIIKTDDPIDAIEQMEIELSRLTNELTSREKKLAISAESVANILRKTIQREQNRILQLNQGLQNIAFGQVKGVRLVVNIRDTHAILLNALSNGREEHKDLFDSQKLSFSEALAMLYKRVNPHIEMGQRTPQTIGEELLDYRNYLDLEVETFRGADGWMRAESSALSTGEAIGTGMSILLMVVQSWEEESRRMRAKDILPSRLLFLDEAARLDATSINTLFELCERLDMQLLIAAPENISPERGTTYKLVRKITNNQEYVHVVGLKGFGQQ
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: SEN34_MOUSE
Sequence: MLVVEVANGRSLVWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPLLLLPEEARLLAEIGAVTLVSAPRPDPRNHGLALASFKRQQEQSFQDQNTLAAEARETRRQELLEKIVEGQAAKKQKLEQDSGADEGGQEAGGSEATQGSETSDDGQPSAEQEGAAPSLDSSSPQPGPSNGVTPLPRSALLIQLATARPRPVKAKPLDWRVQSKDWPHAGRPAHELRYSIYRDLWERGFFLSAAGKFGGDFLVYPGDPLRFHAHYIAQCWSAEDPIPLQDLVSAGRLGTSVRKTLLLCSPQPDGKVVYTSLQWASLQ
What is the function of this protein?
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA.  It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron.  The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini.  There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.  The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity).
What are the official names of this protein?
tRNA-splicing endonuclease subunit Sen34, Leukocyte receptor cluster member 5 homolog, tRNA-intron endonuclease Sen34.
What is the protein family that this protein belongs to?
Belongs to the tRNA-intron endonuclease family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus.
Protein: NUOI_SULDN
Sequence: MHNEHIEEHFNNRNVTELSSEYYMVDIAPYPTDGWGKFTRTLRRAIRGELFVGLWVVLREMIRFDIHTIQYPLEKMPIGPRYRAVHEMKRLWESDTERCIGCGLCEKICISNCIRIDTKLDENSRKEVTEYSINLGRCIFCGYCAEVCPELAITHGGEYENASDQREHFIMYQDMLTPLDKMKAGTQKEFEGFGAITPHEDERVKKTPLAY
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CTAA_NEOSM
Sequence: MSYRTWLAVCILLILSMVSIGGFTRLTESGLSITEWKPVTGVIPPLSKNAWQKEFDKYKNTPEYKVRHFSISYAEFQFIYLVEYFHRLVGRILGLVFFIGLVYFFVVGNLARESRLRLCFALVLGVIQGFVGWYMVKSGLLDVPAVSHYRLALHLFCASLLFMVLVYEFLSPTVIKGSVFKWHLVGCSLMFLLSMQIILGGLVAGLKAGLICSTFPLMNGEFFPAEIFHELSLNCFNDPVAVQFLHRMSAFLLTFICLVCLVISFFYDRAFRARVFLVASMMLLQMFFGVLTLLFHIPIDIALLHQIMAFILLGICVSFLRVRSG
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEM3_BURTA
Sequence: MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALADGRADLAVHSLKDVPMELPAGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARYPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVEDSLPAAGQGALGIEIAAGRADVAAWLAPLHDHATALAVEAERAVSRALGGSCEVPLAAHAVWRGDELHLTGSVSTTDGARVLAARAQSRAATAADALALGRAVSDELERQGARAIVDALVAASAQAQKGGA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: KCNA4_BOVIN
Sequence: MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGGGGSGGSQHHHHPSRGACTSHDPQSGRGSRRRRRPHPEKKKVHHRQSSFPHCSDLMPSGSEEKILRDLSEEDEEEDDEEDEEEEGRFYYSEEDHGEECSYTDLLAQDDGGGGGGGSGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLIMALSTGGHGGLLNDTSAPHPENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEKCQGKGDDSETDKNNVSNAKAVETDV
What is the function of this protein?
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.  Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient.  The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:1505668).  Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity).  Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation.  In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member.  Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:1505668).  Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (By similarity).
What are the official names of this protein?
Potassium voltage-gated channel subfamily A member 4, BAK4, Voltage-gated potassium channel subunit Kv1.4.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon.
Protein: LIS1_AEDAE
Sequence: MYVRRLRRERSNQAIADYLGSNGYTDALEAFRKEADMPNEIERKYGGLLEKKWTSVIRLQKKVMELEAKLSEAEKEAIEGAPTKAKRTPTDWIPRPPEKFALAGHRATVTRVVFHPVFSMMASASEDATIKIWDFETGEYERTLKGHTDSVQDLAFDSHGKLLASCSSDLSIKLWDFQQTFECVKTMHGHDHNVSSVSFVPAGDYLLSASRDKTIKMWEVATGYCVKTFTGHREWVRMVRVNVDGSLMASCSNDHSVRVWQTNSKECKAELREHENTVECIAWAPESAAAAINEAAGADNKKGAHQGPFLASGSRDKTIRVWDVNSGLCLFTLVGHDNWVRGIVFHPGGKYMLSASDDKTLRIWDLRNKRCMKTLYAHSHFCTSLDMHKSHPYVISGSVDTTVKVWECR
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for several dynein- and microtubule-dependent processes.
What are the official names of this protein?
Lissencephaly-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the plus end of microtubules and to the centrosome.
Protein: PURL_PARMW
Sequence: MSSPAYDVIAALKQEGLKPSDWQEICRRLGREPNRAELGMFGVMWSEHCCYRNSRPLLRGFPTEGPRILVGPGENAGVVDLGEGHRLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNALRFGPLEDPVNVGLIEGVVAGIAHYGNCVGVPTVGGEVAFDPSYGGNPLVNAMALGLMETEEIVKSGAQGVGNPVVYVGSTTGRDGMGGASFASAELSADSLDDRPAVQVGDPFLEKGLIEACLEAFSGGDVVAAQDMGAAGLTCSCSEMAAKGGLGVELDLDRVPAREEGMTAYEFLLSESQERMLFVVKAGREEALMQRFRRWGLQAAVVGQVLQEPLVRVLHHGEVAAEVPATALADDTPIEQHELLQEPPADLQELWQWQESQLPALDDPASVLLTLLDDPTIASKRWVHRQYDQQVLANTVVSSGAADAAVVRLRPQQGQGSMESVQRGVAATVDCPNRWVALDPERGAQAAVAEAARNLSCVGAEPLAITDNLNFPSPETPKGYWQLAMACRGIAEACRALNTPVTGGNVSLYNETRRDDGTLQPIHPTPVVGMVGLVENIERVVGLGWRQPGDAVLLLGVAPDEQGDDRLGLAGSSYQMLVSGVLAGRPPRVDFELERGVQQLLRQAIDAGLLASAHDSSDGGLAVALAESSIASSLGVELKLNGRPEGLTRTLFAEGGARVAISVKAECRPQWDQLAAESTVPITELGVVNDGSTFRIHCGEKDVQWSLADLKRAHQEGLPRRIGGEAES
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSV1_SCHPO
Sequence: MKSYECPFCKRVFHRQEHQVRHIRSHTGEKPFECSYPSCKKRFTRRDELIRHVRTHLRKALVTPEQTLDVNLHKAPDSKPEGDKSTGQEADKSQNQSKDGSITDPVQAAVLALSVAYAKPTSVSLSPTDLQAQSKLIEKPRRRSASNATGSLNKKNQDPLRRFSISESAGAAAPTPSPSNSKSPPSENRKNRLQNVLSPIASNNVPDFNQNYPTESNPMFLSTPRFQNTNGQRTLTVPVSVWDARQPPTSSRSGLPLSVMYNHFPSVPIPPATVNDTSMEYYLPNAYPHPTGISLPFYPFDSGIPVSPNIPVSPSSSFVPMYPTTFPSSKPQIVNAPPAPSYFSPGSSFGAQLCANGSTLLRADTKQYGLALPKITNSNLISPNQTFNPVKSSVKALPTLEPPSSPSHATATSSLHTLFHTAPSRSYD
What is the function of this protein?
Involved in maintaining cell viability under glucose starvation conditions.  May have a role in regulating genes involved in gluconeogenesis.
What are the official names of this protein?
Zinc finger protein rsv1, Required for stationary phase viability protein 1.
What is the protein family that this protein belongs to?
Belongs to the creA/MIG C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.