PharMolix/UniProtQA huggingface dataset:
Protein: RPOA_DICNV
Sequence: MALTELLTPRIVQIKEIGSNTSRVTLEPLERGFGYTLGTALRRVLLSSIEGAAITECQIDGVSHEYSAIEGVKEDVIDVLLNLKNIALLMPDLERAEIRLSVTEKGAITAGDFELPAGVEIVNPDCVIAHLTRDIPFSLTAVVEKGRGYRVAPQADDNSESTRSNVLRLDASFSPVRRIAYRVEQARVEQRTDLDKLIIEIESNGTIDPEQAIRDAATILHNQIKVFVDLESTEEETEEEEEIYIDPVLLRPVDDLELTVRSANCLKAENINNIGDLVRRTEVELLKTPNLGKKSLNEIKEVLAAHNLELGMDIENWPQN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RPOA_CITK8
Sequence: MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: MUKB_CITK8
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDVLNSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLTLAELKEKLDAMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELYTSRKQLAAEQYKHVDMARELGEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAADMQEENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAIQALDRAKALCHLPDLTADSAAEWLETFQAKEQEATEKLLSLEQKMSVAQTAHSQFEQAYQLVAAINGPLARNEAWSVARDLLREGVEQRHLAEQVQPLRMRLSELEQRLREQQEAERLLAEFCKRQGKHFDIDELEALHQELEARIAALSDSVSNAHEQRMTLRQEQEQLQSRIQHLMQRAPIWLAAQNSLNQLCEQSGEEFTSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGSEDSRLNALAERFGGVLLSEIYDDVSFEDAPYFSALYGPSRHAIVVPDLSLIAEQLEGLTDCPEDLYFIEGDPQSFDDSVFSVDELENAVVVKTAERQWRYSRFPTVPIFGRAARENRIESLHAEREGLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFEADPEAEIRQLNGRRVELERALATHENDNQQQRIQFEQAKEGVSALNRLLPRLNLLADDTLADRVDEIQERLDDAQEAARFIQQHGNQLAKLEPIVSVLQNDPEQFEQLKEDYAYSQQTQRDARQQAFALTEVVQRRAHFSYSDSAEMLSGNSDLNEKLRQRLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLGDLQRELQDIGVRADSGSEERARIRRDELHTQLSNNRSRRNQLEKALTFCEAEMDNLTRRLRKLERDYHEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADELRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQNVSFGQVNSVRLNVNVRETHATLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDEGRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFHNTEHVHVVGLRGFAPQLSETLPGTGTEDASSQAAG
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: MBIP1_HUMAN
Sequence: MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP
What is the function of this protein?
Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway.  Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
What are the official names of this protein?
MAP3K12-binding inhibitory protein 1, MAPK upstream kinase-binding inhibitory protein, MUK-binding inhibitory protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shows a cytoplasmic localization when coexpressed with MAP3K12.
Protein: PROB_BURL3
Sequence: MRSIIADSKRLVVKVGSSLVTNDGKGLDHAAIGRWAAQIAALRAQGKEVVLVSSGAIAEGMQRLGWSKRPREIDELQAAAAVGQMGLAQVYESRFTEHDIRTAQILLTHADLADRERYLNARSTMLTLLRLGVVPIINENDTVVTDEIKFGDNDTLGALVANLIEGDALIILTDQSGLFTADPRKDPNATLVAEANAGAPELEAMAGGAGSSLGRGGMLTKILAAKRAAHSGANTVIASGRETDVLVRLAAGEAIGTQLIARTARMAARKQWMADHLQVRGHVVIDAGAVEKLTAGGKSLLPIGVIDVQGAFARGEVIACVGPDGREVARGLTNYSSAETKLIHRKPSGEIESVLGYMLEPELIHRDNLVLV
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_PSEMY
Sequence: MESLKQKILSEGIVLSDQVLKVDAFLNHQIDPALMQQIGHEFAQRFAGQGITKIVTIEASGIAPAVMAGLELGIPVIFARKFQSLTLKDDLLISKVFSFTKQTESTIAISARHLTAADKVLVIDDFLANGHAAKALIDLIQQAGAQVAGIGIVIEKSFQEGRNLLESEGYRVESLARVAALENGQVRFLD
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_ACTP2
Sequence: MLQVNVELKERRYPITIGAGLLGDPNSYSSLKAGDKVMIVSNPTVAAHYLATVTNTLNGLGCSVDSVLIPDGEKYKTLDSLNMIFTALLEKNHNRDTTLIALGGGVIGDVAGYAAASYQRGIRFIQIPTTLLAQVDSSVGGKTAVNHPLGKNMIGAFYQPISVIIDTNTLQTLPKREVSAGLAEVIKYGAIFDIHFFEWLESNIHHLVALKQNELEYCIQRCCQLKADVVARDETEKGDRALLNLGHTFGHAIEAHLGYGNWLHGEAVSVGMLEAAELSRILGDLSAQDVSRLERLLAQAVLPTISPDGMEPSEYLPYMWRDKKVLGGQLRLVLLKSLGKAYVTAQASEQQVLSAIERFTQREFHE
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URT1_ARATH
Sequence: MADGGAEPPAPPSSINAGEFLLSILHGSPSPSSQGPQHHQSFALDPAIAAIGPTVNNPFPPSNWQSNGHRPSNHNPPSWPLAFSPPHNLSPNFLGFPQFPPSPFTTNQFDGNQRVSPEDAYRLGFPGTTNPAIQSMVQQQQQQQLPPPQSETRKLVFGSFSGDATQSLNGLHNGNLKYDSNQHEQLMRHPQSTLSNSNMDPNLSHHRNHDLHEQRGGHSGRGNWGHIGNNGRGLKSTPPPPPPGFSSNQRGWDMSLGSKDDDRGMGRNHDQAMGEHSKVWNQSVDFSAEANRLRGLSIQNESKFNLSQQIDHPGPPKGASLHSVSAADAADSFSMLNKEARRGGERREELGQLSKAKREGNANSDEIEDFGEDIVKSLLLEDETGEKDANDGKKDSKTSREKESRVDNRGQRLLGQKARMVKMYMACRNDIHRYDATFIAIYKSLIPAEEELEKQRQLMAHLENLVAKEWPHAKLYLYGSCANSFGFPKSDIDVCLAIEGDDINKSEMLLKLAEILESDNLQNVQALTRARVPIVKLMDPVTGISCDICINNVLAVVNTKLLRDYAQIDVRLRQLAFIVKHWAKSRRVNETYQGTLSSYAYVLMCIHFLQQRRPPILPCLQEMEPTYSVRVDNIRCTYFDNVDRLRNFGSNNRETIAELVWGFFNYWAYAHDYAYNVVSVRTGSILGKREKDWTRRVGNDRHLICIEDPFETSHDLGRVVDKFSIRVLREEFERAARIMHQDPNPCAKLLEPYIPEDNNGQGHN
What is the function of this protein?
UTP:RNA uridylyltransferase with a marked preference for uridine polymerization and a distributive activity for the first added nucleotides (PubMed:23748567, PubMed:25928405).  Uridylates oligo(A)-tailed mRNAs to prevent 3' to 5' ribonucleotytic attacks (PubMed:23748567).  Reduces the accumulation of oligo(A)-tailed mRNAs (PubMed:33637717).  Prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis (PubMed:26972004, PubMed:33637717).  Uridylation repairs deadenylated extremities to restore the size distribution observed for non-uridylated oligo(A) tails (PubMed:26972004).  Can prevent the 3' trimming of mRNAs still engaged on polysomes (PubMed:23748567).  Acts synergistically with HESO1 in unmethylated miRNA uridylation, leading to their degradation (PubMed:25928341).  URT1 and HESO1 prefer substrates with different 3' end nucleotides and act cooperatively to tail different forms of the same miRNAs (PubMed:25928405).  URT1 and HESO1 act sequentially, with URT1 mono-uridylating the miRNAs followed by their further uridylation by HESO1 (PubMed:25928405).  URT1 and HESO1 are involved in the uridylation and clearance of RISC-generated 5' mRNA fragments (PubMed:30364210).  Has no effect on uridylation of heterochromatic siRNAs (PubMed:25928341).  Able to act on AGO1-bound miRNAs and the uridylated species stay associated with AGO1 (PubMed:25928405).  Acts as post-transcriptional gene silencing (PTGS) suppressor (PubMed:31076735).
What are the official names of this protein?
UTP:RNA uridylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, P-body. Note=The P618L single amino acid substitutiontarget URT1 to the nucleoplasm.
Protein: CP17A_BISBI
Sequence: MWLLLAVFLLTLAYLFWPKTKHSGAKYPRSLPSLPLVGSLPFLPRRGQQHKNFFKLQEKYGPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHGAHWQLHRKLALNAFALFKDGNLKLEKIINQEANVLCDFLATQHGEAIDLSEPLSLAVTNIISFICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDIFPVLKIFPSKAMEKMKGYVQTRNELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNAGPDQDSKLLSSRHMLATIGDIFGAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPAISDRNRLVLLEATIREVLRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEWQHPDLFMPERFLDPTGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDDGKLPSLEGHASLVLQIKPFKVKIEVRQAWKEAQAEGSTP
What is the function of this protein?
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis.  Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways.  A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage.  The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol.  Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione.  Has 16-alpha hydroxylase activity.  Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA.  Also 16-alpha hydroxylates androgens, relevant for estriol synthesis.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Microsome membrane.
Protein: LEUD_ANADE
Sequence: MEPIRVIESRTVVLPRENVDTDQIIPARFLKVTDKKGLGKALFSDWRYAADGSPRPDFVLNRPEAQGCSILVAGDNFGCGSSREHAPWALVDAGVRAVISTRIADIFRNNALKNGLVPVVLDPASHAKLLAAPGASVRVDVEAQTVTLPDGSTAKFPIDGFARYCLLNGVDELGFLLAQDADIAAFEGGRR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: PGKH_CHLRE
Sequence: MALSMKMRANARVSGRRVAAVAPRVVPFSSASSSVLRSGFALRCLWTSAAWAALASVVEAVKKSVGDLHKADLEGKRVFVRADLNVPLDKATLAITDDTRIRAAVPTLKYLLDNGAKVLLTSHLGRPKGGPEDKYRLTPVVARLSELLGKPVTKVDDCIGPEVEKAVGAMKNGELLLLENCRFYKEEEKNEPEFAKKLAANADLYVNDAFGTAHRAHASTEGVTKFLKPSVAGFLLQKELDYLDGAVSNPKRPFVAIVGGSKVSSKITVIEALMEKCDKIIIGGGMIFTFYKARALKVGSSLVEDDKIELAKKLEEMAKAKGVQLLLPTDVVVADKFDANANTQTVPITAIPDGWMGLDIGPDSVKTFNDALADAKTVVWNGPMGVFEFPQVRQRTVSIANTLAGLTPKGCITIIGGGDSVAAVEQAGVAEKMSHISTGGGASLELLEGKVLPGVAALDEK
What are the official names of this protein?
Phosphoglycerate kinase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CLPP_RUBXD
Sequence: MSYYDPQGVIPYVIEQSPRGERAMDIYSRLLKDRIIFLGTPVDDQVANAIMAQLLHLESEDPEQDINLYINSPGGSVSAGLAIYDTMQFVKPDIVTTALGMAASMGAFLLAAGTKGKRFALPNTRILLHQPAVGGLAGQASDVEIHARELIRTKRRLNEILSEHTGQPYDKIERDTDRDFIMGAEEAIEYGLIDDIVRHH
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y798_BURVG
Sequence: MSKPSDRINLTNQFLIAMPNMADPTFSGTVVYLCDHSERGALGLVINRPTDIDLESLFNRIDLKLDIEPLLHIPVYFGGPVQTERGFVLHEPVEGANYNSSMSIEGGLEMTTSKDVLEAVATGTGPKRFLLTLGHAGWGAGQLEEEISRNGWLTVPADPRIVFDTPAEERFEAALGLLGVSSSMLSGEAGHA
What are the official names of this protein?
UPF0301 protein Bcep1808_0798.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: NS1_PAVHH
Sequence: MAGNAYSDEVLGVTNWLKDKSSQEVFSFVFKNENVQLNGKDIGWNSYRKELQDDELKSLQRGAETTWDQSEDMEWESAVDDMTKKQVFIFDSLVKKCLFEVLSTKNIAPSNVTWFVQHEWGKDPGWHCHVLIGGKDFSQPQGKWWRRQLNVYWSRWLVTACNVQLTPAERIKLREIAEDSEWVTLLTYKHKHTKKDYTKCVLFGNMIAYYFLSKKKICTSPPRDGGYFLSSDSGWKTNFLKEGERHLVSKLYTDEMKPETVETTVTTAQEAKRGRIQTREEVSIKTTLKELVHKRVTSPEDWMMMQPDSYIEMMAQPGGENLLKNTLEICTLTLARTKTAFDLILEKAETSKLANFSMASTRTCRIFAEHGWNYIKVCHAICCVLNRQGGKRNTVLFHGPASTGKSIIAQAIAQAVGNVGCYNAANVNFPFNDCTNKNLIWVEEAGNFGQQVNQFKAICSGQTIRIDQKGKGSKQIEPTPVIMTTNENITVVRIGCEERPEHTQPIRDRMLNIHLTRTLPGDFGLVDKHEWPLICAWLVKNGYQSTMACYCAKWGKVPDWSEDWAEPKLDTPINSLGSMRSPSLTPRSTPLSQNYALTPLASDLADLALEPWSTPNTPVAGTAASQNTGEAGSTACQGAQRSPTWSEIEADLRACFSQEQLESDFNEELTLD
What is the function of this protein?
Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication.  Also plays a role in viral packaging and transactivation of several promoters.  Binds site-specifically to 2-3 approximate tandem copies within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR).  Cooperatively binds Ori with host PIF and probably other host factors, which activate the nickase function of NS1.  Becomes covalently attached to the 5' end of the nick and provides a 3'OH for priming DNA synthesis.  The helicase activity unwinds DNA in a 3'-5' direction on the longer strand.  Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition.  These arrests may provide essential cellular factors for viral DNA replication.  Promotes apoptosis in host cell.
What are the official names of this protein?
Initiator protein NS1, NS1, NCVP1, Non-capsid protein NS-1, Non-structural protein 1, Non-structural protein NS1.
What is the protein family that this protein belongs to?
Belongs to the parvoviruses initiator protein NS1 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: CH60_STRAP
Sequence: MAKDIKFSADARSAMVRGVDILADTVKVTLGPKGRNVVLEKSFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGIKNVTAGANPIGIRRGIETAVATAVEALKANSVPVSNKEAIAQVAAVSSRSEKVGEYISEAMEKVGNDGVITIEESKGMETELDVVEGMQFDRGYLSQYMVTDNEKMVADLDNPYILITDKKISNIQEILPLLENILKTSRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATIEALGQASKVTVDKDSTVIVEGSGDAEAIANRVAVIKSQIESSTSDFDREKLQERLAKLSGGVAVIKVGAATETELKEMKLRIEDALNATRAAVEEGIVSGGGTAFVNVLSAVEALDLSGDEATGRNIVLRALEEPVRQIALNAGFEGSIVIDRLKNSEAGTGFNAATGEWVNMIDAGIIDPVKVTRSALQNAASVASLILTTEAVVANQPEPASPTPAMDPSMMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_BACHK
Sequence: MAITAQMVKELREKTGAGMMDCKKALTETNGDMEKAIDFLREKGIAKAAKKADRIAAEGLTFIETNGNDGLILELNSETDFVAKNEGFQTLIKELAAHLLANKPANVEEAMAQTMENGKKVEEHINEAIAKIGEKLTLRRFEIVSKTDADAFGAYLHMGGRIGVLTVLEGSTDEAAAKDVAMHIAAVNPKYIDRDAVTAEEVEHERQVLTQQALNEGKPEKIVAKMVEGRLGKFFEEICLLDQAFVKNPDMKVRQFVESKGGTLKGFVRYAVGEGIEKREDNFAEEVMNQVKGSN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS2_STAAN
Sequence: MRQKTLDVLEFEKIKSLVANETISDLGLEKVNQMMPATNFETVVFQMEETDEIAQIYNKHRLPSLSGLSKVSAFIHRADIGGVLNVSELNLIKRLIQVQNQFKTFYNQLVEEDEGVKYPILDDKMNQLPVLTDLFHQINETCDTYDLYDNASYELQGIRSKISSTNQRIRQNLDRIVKSQANQKKLSDAIVTVRNERNVIPVKAEYRQDFNGIVHDQSASGQTLYIEPSSVVEMNNQISRLRHDEAIEKERVLTQLTGYVAADKDALLVAEQVMGQLDFLIAKARYSRSIKGTKPIFKEERTVYLPKAYHPLLNRETVVANTIEFMEDIETVIITGPNTGGKTVTLKTLGLIIVMAQSGLLIPTLDGSQLSVFKNVYCDIGDEQSIEQSLSTFSSHMTNIVEILKHADKHSLVLFDELGAGTDPSEGAALAMSILDHVRKIGSLVMATTHYPELKAYSYNREGVMNASVEFDVDTLSPTYKLLMGVPGRSNAFDISKKLGLSLNIINKAKTMIGTDEKEINEMIESLERNYKRVETQRLELDRLVKEAEQVHDDLSKQYQQFQNYEKSLIEEAKEKANQKIKAATKEADDIIKDLRQLREQKGADVKEHELIDKKKRLDDHYEAKSIKQNVQKQKYDKIVAGDEVKVLSYGQKGEVLEIVNDEEAIVQMGIIKMKLPIEDLEKKQKEKVKPTKMVTRQNRQTIKTELDLRGYRYEDALIELDQYLDQAVLSNYEQVYIIHGKGTGALQKGVQQHLKKHKSVSDFRGGMPSEGGFGVTVATLK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: RF2_CORA7
Sequence: MRPEQTARLEELSATLTSIEKVMDPEAVSERVRELEAQAGDPSLWDDPDHAQKVTSELSAQQAKLRKLNSLRGRIEDLPVMSELAEEEGDEASQELVETELKELGAAIESLEVTTMLSGEYDEREAVINIRSGAGGVDAADWAEMLMRMYTRWAEKNGHKVDVYDISYAEEAGIKSATFVVHGEYMYGQLSVEQGAHRLVRISPFDNQGRRQTSFAEVEVLPVVEQTDSIEVPDSEVRVDVYRSSGPGGQSVNTTDSAVRLTHIPTGIVVTCQNEKSQIQNKASAMRVLQAKLLERKRQEERAELDALGAGGNASWGNQMRSYVLHPYQMVKDLRTNYEVGDPSKVLDGDIDGFLESGIRWRMAQQEA
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALBA_THEON
Sequence: MAEEHVVYIGKKPVMNYVLAVITQFNEGAKEVSVKARGRAISRAVDVAEIVRNRFLPEVRVKEIKIGTEELPTADGRTANTSTIEIILEKP
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
What are the official names of this protein?
DNA/RNA-binding protein Alba.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: GLMM_BURCH
Sequence: MGRRYFGTDGIRGTVGEAPITPDFVLRLGYAAGKVLAGSADVAAGSRPTVLIGKDTRVSGYMLEAALEAGFSAAGVDVMLAGPMPTPGVAYLTRALRLSAGVVISASHNPYHDNGIKFFSADGNKLPDDTEAAIEAWLDKPLECAPSDGLGKARRLDDAAGRYIEFCKSTFPAAFDLRGLKLVIDCAHGAAYQIAPHVFHELGADVIPIGVAPNGFNINDGVGATAPDALVRAVRANHADLGIALDGDADRLQVVDATGRLYNGDELLYVLVKDRIATDGKVDGAVGTLMTNLAVEVALQREGVKFVRAAVGDRYVLEQLREHGWQLGAEGSGHILSLDRHSTGDGIVSALLVLAALKRSGRTLAQVLDGVTLFPQKLINVRMKPGADWKGSASIRAAIDAAEAALAGSGRVLIRASGTEPVLRVMVEAQQAADAVRHAETIADAVRAATT
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RL18_PROM5
Sequence: MAKISRKLQTQKRHKRLRRYLIGNKIRPRLAVFRSNNHIYAQVIDDDAQQTICSASTVDKELKEDSDKLSPNCSSSTIVGKLLAKRAIKKGIKQVIFDRGGNLYHGRVKALADAARDAGLNF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: OAT_VIGAC
Sequence: MFKPHLLAVVSRCNSFFGCVDICCNWGNSAPRTLKGLKSVTSEQVFEREQKYGAHNYHHCSAYRAKGVSLDMEGKRYFDFLSAYSAVNQGHCHPKIVNTMVEQAQRLTLTSRAFYTDVLGEYEEFLTKLFNYDKVLPMNTGVEGGETACKIARCWAYMKKKVPENQAKIIFAENNFWGRTLSAISASTDPMSYDELRPYMPGFEIVKYNDTAALEKAFQDPNVCAYMVEPIQGEAGVVALDAGYLTEVRELCTKYNVLFIADEVQTGLARTGRMLAVDHEDVKPDLLILGKALSGGLYPVSAVLRDDHIMDCIQPGLHTAMDVMDPRMRILAASRYYVRVARERCENAQIQATYLRKELNTLPKDVVPVVRGKGLLNAIVINKKFDAWDVCLNLCKPTHGDIIRFATTGHHRGTDPRMCQYYQKYH
What are the official names of this protein?
Ornithine aminotransferase, Ornithine--oxo-acid aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: COS3_YEAST
Sequence: MKENELKNEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIYKSLAFRIWMLLWLPLSVWWKLSNNCIYPLIVSLLVLFLGPIFVLVICGLSRKRSLSKQLIQFCKEITENTPSSDPHDWEVVAANLNSYLYENNVWNTKYFFFNAMVCQEAFRTTLLEPFSLKKDKAAKVKSFKDSVPYIEEALGVYFTEVEKQWKLFNTEKSWSPVGLEDAKLPKEAYRFKLTWFLKRISNIFMLIPFLNFLCCIYVSRGMCLLLRTLYLGWILFMLVQGFQNIRVLIMSMEHKMQFLSTIINEQESGANGWDEIARKMNRYLFEKKAWKNEEFFFDGIDCEWFFNHFFYRVLSAKKSMWPLPLNVELWPYIKEAQLSRSEVLLV
What are the official names of this protein?
Protein COS3.
What is the protein family that this protein belongs to?
Belongs to the DUP/COS family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.