PharMolix/UniProtQA huggingface dataset:
Protein: HIS6_STAEQ
Sequence: MIKKRVIPCLDVKDGRVVKGIQFQSLRDIGNPVDLALYYNEAGADELVFLDISKTEAGHDLMIEVIEATAKQLFIPLTVGGGIQNLDDITQLLNHGADKISLNSSALKHPELIRQASEKFGRQCICIAIDSFYDKDREDYFCTTHGGKKLTDVSVYDWVQEVEHLGAGELLITSMHHDGMKQGFDIEHLAKIKQLVNIPIIASGGGGNAQHFVELFQQTDVSAGLAASILHDQETTVAEIKDKMREGGILVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_SINFN
Sequence: MKRDLYETLGVKKNADEKELKSAFRKLAMKYHPDRNPGDQEAEKSFKEINEAYETLKDPQKRAAYDRYGHAAFEQGGMGAGFGNGFAGGSAGGFSDIFEDIFGEMMGGRQRRSSGGRERGADLRYNMEITLEEAYSGKTAQIRVPTSVTCDVCTGSGAKPGTSPKTCATCQGSGRIRAAQGFFSIERTCPTCGGRGQTITDPCTKCHGQGRVTEERTLSVNIPTGIEDGTRIRLSGEGEAGLRGGPAGDLYIFLSVKPHEFYQRDGADLYCSVPISMTTAALGGKFDVTTLDGTKSRVTVPEGTQAGKQFRLKGKGMPVLRSNQTGDLYIQIQIETPQKLTKRQRELLQEFEQISSKENNPQSTGFFSRMKDFFDTLSE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VERA_CLORO
Sequence: MPIDAESEAELRSEAEAPPGGFGKLMRVFTFATAVDRLIQIGCAFAAVCSGAAMPLMALILGRLTANFTDYGSSGDDKSTAEFMKSVQTNALWFVYLFIGKFTLVYLWSFGFTFTASRMLQAMRLTCLDRILDRTVAANDEETPGSLSNTVTSQCNSIQAALSDRLGIMIQAFSMLLASFAVAFSQSWQLTLVMLGLVIITLGLIGFIVSSDQKIEAGLLKRYAECSIIAEDALGSIRTVIAFGAAHKFLAKYNEILKKTETDGKKKGPFVGLMFACQYFFMFVGWAIGFYLGAYLFTKGMISDPGRILSVFFAMLIGLGAIMALGPNMPSFIKAIAAADVAFKILDDGTDQNQDSESQKDASQPEKIACQGHVELRDMSFAYRGREDRNALDKINLSFERGTSTAIVGPSGAGKSTLISLLERWYEPTAGSIFLDGNDIFQLDPKWLRSQIALVQQEPQLFNASIFDNIAYGLIGTEQENLSPEDKQTLVHDACRHARAYEFITKLPESFDTMVGDRASLISGGQKQRIAIARALVARRPILLMDEATSALDNENSKVIEALMTNSIDRTTIFISHKIRAATKADRVVVLDHGKVSEQGTHEELLSAGGLYKRLYDAQTEVESSDDEDPIKTITKTPIPTVVEKTEEASGGPQASIAEPSDNLPQIPKRNLLANLWEIAKEQRRYWPIFLIGLVACVVTAQIFPVQAILLGRVMQVFQGPPEKVSSDANFWSLMFFVVGLGAMISYAILGFFMTLLGVYLTRFYRLEYFRAVLQQPVEFFDRVASGTLLSRLSSDPSNLHELISINMGLLISIFVSVISASIIGLAYSWKFALVAIFAAMPAVFAAGYLRMKLDSSLAEEMEKISEESARFVSDSLSAFRTVKAFTMETAVHHMYNECLVSFAGRLYRQRAVMTLFFAFSESVELLASALGFWYGGKLMGDGELSTEKFFTVFIAVVVGGQAAGALFGFSSNLGKAKIAANNILGIRSQVRAAAARDQSRQMAEENHSEKTENTVVDMQNVTFAYPARPNVPVLKGISFKVYRGQTVGVVGTSGSGKSTLLALLERFYEAQSGTVNVLGRPISAHDIDEYRKRLAIVPQEPQLYNGTVRDNVILGLDEDKVQEADVATACEAAGLGEFISSLPDGFNTQCRGQGVSFSGGQKQRVAIARALIMHPELLLLDEPTSALDAESEQLVRETLGNIQEGRTMILVTHRLNIVRNAHVIIVMDGGRIVEQGTHTELMAKQGNYFKMHESSNGGEA
What is the function of this protein?
ABC-type transmembrane transporter; part of the gene cluster that mediates the biosynthesis of 11'-deoxyverticillin A, one of the dimeric epipolythiodioxopiperazines (ETPs) from the verticillin family that are toxic secondary metabolites (PubMed:28376389).  The verA multidrug transporter is probably involved in the secretion of 11'-deoxyverticillin A (Probable).
What are the official names of this protein?
ABC-type transmembrane transporter verA, Verticillin biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RHDF1_DANRE
Sequence: MAELRRDSTSSLQRKKPPWLKLDIPTAHVSVDEVPAFVPPVKRQGFHRSASMPVETSHFHSPQRDIIDHRRAAFQRQSSITQTIKRGTADWFGVSKDGDATQKWQRKSLRHCSLRYGKLKPQVIREMELPSQDNISLTSTETPPPLYVPSSQHGMQKIVDPLARGRAFRMVEEVDGYSVPQTPITPGAASICSFNSSRSGLNRIPRRRKRESVAKMSFRAAAALVKGRSLREGTLRRAHRRSFTPASFIEEDVVDFPDELDTSFFARDIMMHEEMSTFHDEVFESPSDSTMKDVDSKQLDESELTGSALDKSELEKSHLMLPLERGWRKVKEKTPAPPKIRLKQEVVSVNGQRRGQRIGLPVKKLFAREKRPYGLGMVGKLTNRTYRKRIDSYVKKQIEDMDDHRPFFTYWITFVHILITILAVCIYGIAPVGFSQHETVDSVLRNKGVYENVKFVQQENFWIGPSSEALIHLGAKFSPCMRRDNQVHELIKKKQELERNSACCVRNDRSGCLQTSEEECSSTLAVWVKWPQHPSVPQLDGVARQHGSVCHQDPRTCTEPASVSPHEWPDDITKWPICTKYNSGNHTNLPHIDCTITGRPCCIGTKGRCEITSREYCDFMKGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSVCFQMTILRDLEKLAGWLRISIIYILSGITGNLASAIFLPYRAEVGPAGSQFGILACLFVELIQSWQILAQPWRAFTKLLCVVLFLFAFGLLPWIDNFAHISGFISGFFLSFAFLPYISFGRLDMYRKRCQIIIFLVVFLGLFAGLVVLFYVHPIKCEWCELLTCIPFTDKFCEKYDLNAHLH
What is the function of this protein?
Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation.  Does not exhibit any protease activity on its own.
What are the official names of this protein?
Inactive rhomboid protein 1, iRhom1, Rhomboid family member 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly localized in the endoplasmic reticulum membrane.
Protein: BGL33_ARATH
Sequence: MATATLTLFLGLLALTSTILSFNADARPQPSDEDLGTIIGPHQTSFDDEIGIVIGPHATVDDEDIDMDMGTTVGPQTNLNDDDLGTIIGPEFEIHKQDFPADFIFGTSVSAYQVEGAKKGSGRGLTSWDEFTHMFPEKVQQNGDGDEGVDFYTRYKDDIKLMKELNTNGFRFSISWTRILPYGTIKKGVNEEGVKFYNDLINELLANGIQPSVTLFHWESPLALEMEYGGFLNERIVEDFREFANFCFKEFGDRVKNWATFNEPSVYSVAGYSKGKKAPGRCSKWQAPKCPTGDSSEEPYIVAHNQILAHLAAVDEFRNCKKVEGGGKIGIVLVSHWFEPKDPNSSEDVKAARRSLEYQLGWFLRPLTYGQYPAEMLEDVNIRLREFTPEESEKLRKSLDFVGLNYYGAFFSTPLAKVNSSQLNYETDLRVNWTVITNNLSLPDLQTTSMGIVIYPAGLKNILKHIKDEYMDPEIYIMENGMDEIDYGTKNITEATNDYGRKEFIKSHILIMGKSIRMDKVRLKGYYIWSLMDNFEWDKGYKVRFGLYYVDYNDNMKRYIRSSGKWLSEFLDSKETLHKCYFEGHREKGYAPKLFDVEYLEPENSQLSYRSDFM
What are the official names of this protein?
Beta-glucosidase 33, AtBGLU33.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: DCUP_YEAST
Sequence: MGNFPAPKNDLILRAAKGEKVERPPCWIMRQAGRYLPEYHEVKNNRDFFQTCRDAEIASEITIQPVRRYRGLIDAAIIFSDILVIPQAMGMRVEMLEGKGPHFPEPLRNPEDLQTVLDYKVDVLKELDWAFKAITMTRIKLDGEVPLFGFCGGPWTLMVYMTEGGGSRLFRFAKQWINMYPELSHKLLQKITDVAVEFLSQQVVAGAQILQVFESWGGELSSVDFDEFSLPYLRQIAERVPKRLQELGIMEQIPMIVFAKGSWYALDKLCCSGFDVVSLDWSWDPREAVKINKNRVTLQGNLDPGVMYGSKEVITKKVKQMIEAFGGGKSRYIVNFGHGTHPFMDPDVIKFFLEECHRIGSK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: FADA_PHOPR
Sequence: MNNVVIVDCIRTPMGRSKAGAFRNVRAEDLSAHLMKGLISRNPQLDPNSIEDIYWGCVQQTLEQGFNVARNASLLAGIPHTVAATTVNRLCGSSMQALHDATRAIMVGDAETCIIGGVEHMGHVPMNHGVDFHPGMSKSVAKAAGMMGLTAEMLGRMHGISRQMQDEFAARSHQRAHAATIEGRFKNEILPIEGHDENGILKLYDYDEVIRPETTVEGLSNLRPAFDPVNGTVTAGSSSALSDGASAMLVMSEHRAKELGLTIRARVKSMAVAGCDPSIMGYGPVPATQKALKRAGLSIDDIGMVELNEAFAAQSLPCAKDLGLLDKIDEKVNLNGGAIALGHPLGCSGSRISTTLINQMEHHDVQFGLATMCIGLGQGIATVFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALP21_SCHPO
Sequence: MHISTGMVRASISNTLVTLTIEGNNDRYQVILDKNVNAKQFVKTCWRNKKPLIVKEGKIFVDKGFPFDPCRTFLEALYEKYSYSSPLPSSVEFKSGKQVEFCGFEKIQSKQRDLKSLRVIILDNYRIEDIEIEYEYSKILPEVIDLDLSRNLFHEFFPILKLCSQLPSLRNLTLDSNLFSNFISSNTVLLIPHLTQLSVNGCGLNSKDVQWITETFPSLEVLYLEANEIILSKATSFKNLQFLQTLSLANNLNLYSADGYAVDVFQGINNLNLSSTSLADVAELPVHTLHKLTFLDISENNIRDIRSLDHLRTLENLKHLRITLSYFNKPTDIAKLLVIARIPSLVKLNDVNISPNERLDAELYYTSCIRKLVIDNEIKDVEELTKIEPFWEEIWKSHELPSIQFHLEASINDWTSGILKNRITKGIKISSINSGATMLLKLHYNWKLLDIKALISYHFAIPVHTSTFVFASSERDVSFSPKTVRDDQKRLFELPFTCTFIDVYAKESGNV
What is the function of this protein?
Required for microtubule and spindle assembly.  Involved in the proper folding of alpha-tubulin.
What are the official names of this protein?
Cell polarity protein alp21, Altered polarity protein 21, Suppressor of tsm one protein 1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ATP6_PSESM
Sequence: MAEQTASGYIQHHLQNLTFGHLPNGDWGFAHTAAEAKEMGFWAFHVDTLGWSVALGLIFVLIFRMAAKKATSGQPGALQNFVEVLVEFVDGSVKDSFHGRSAVIAPLALTIFVWVFLMNAVDLVPVDWIPQLAMMISGDEHIPFRAVPTTDPNATLGMALSVFALIIFYSIKVKGIGGFIGELTLHPFGSKNIFVQALLIPVNFLLEFVTLIAKPISLALRLFGNMYAGELVFILIAVMFGSGLLWLSGLGIVLQWAWAVFHILIITLQAFIFMMLTIVYLSMAHEDNH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VINT_BPP21
Sequence: MAARPRSHKISIPNLYCKLDKRTGKVYWQYKHPLSGRFHSLGTDENEAKQVATEANTIIAEQRTRQILSVNERLERMKGRRSDITVTEWLDKYISIQEDRLQHNELRPNSYRQKGKPIRLFREHCGMQHLKDITALDIAEIIDAVKAEGHNRMAQVVRMVLIDVFKEAQHAGHVPPGFNPAQATKQPRNRVNRQRLSLLEWQAIFESVSRRQPYLKCGMLLALVTGQRLGDICNLKFSDIWDDMLHITQEKTGSKLAIPLNLKCDALNITLREVISQCRDAVVSKYLVHYRHTTSQANRGDQVSANTLTTAFKKAKEKCGIKWEQGTAPTFHEQRSLSERLYREQGLDTQKLLGHKSRKMTDRYNDDRGKDWIIVDIKTA
What is the function of this protein?
Integrase is necessary for integration of the phage into the host genome by site-specific recombination.  In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
What are the official names of this protein?
Integrase.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: RL14_SCHPO
Sequence: MEGFKRYVEVGRVVLVTKGEYTGKLAVIVDIVDHKRALIDSPCSEFPRQVIRYGSVVLTHIVMKLPRGARSGIVAKKWKAQDVCNKWASSAWAKKLEAKKVRSQLNDFDRFAVMRLKKQRREQVNVAVAKALKA
What are the official names of this protein?
60S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL14 family.
Protein: ATO_DROME
Sequence: MSSSEIYRYYYKTSEDLQGFKTAAAEPYFNPMAAYNPGVTHYQFNGNTLASSSNYLSANGFISFEQASSDGWISSSPASHRSESPEYVDLNTMYNGGCNNMAQNQQYGMIMEQSVVSTAPAIPVASPPAVEVMGSSNVGTCKTIPASAGPKPKRSYTKKNQPSTTATSTPTAAAESSASVNLYTEEFQNFDFDNSALFDDSVEDDEDLMLFSGGEDFDGNDGSFDLADGENQDAAAGGSGKKRRGKQITPVVKRKRRLAANARERRRMQNLNQAFDRLRQYLPCLGNDRQLSKHETLQMAQTYISALGDLLR
What is the function of this protein?
Developmental protein involved in neurogenesis.  Required for the formation of chordotonal organs and photoreceptors.  Seems to bind to E boxes.  Specifically required for the photoreceptor R8 selection.
What are the official names of this protein?
Protein atonal.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLGM_MYCTO
Sequence: MRVAMLTREYPPEVYGGAGVHVTELVAYLRRLCAVDVHCMGAPRPGAFAYRPDPRLGSANAALSTLSADLVMANAASAATVVHSHTWYTALAGHLAAILYDIPHVLTAHSLEPLRPWKKEQLGGGYQVSTWVEQTAVLAANAVIAVSSAMRNDMLRVYPSLDPNLVHVIRNGIDTETWYPAGPARTGSVLAELGVDPNRPMAVFVGRITRQKGVVHLVTAAHRFRSDVQLVLCAGAADTPEVADEVRVAVAELARNRTGVFWIQDRLTIGQLREILSAATVFVCPSVYEPLGIVNLEAMACATAVVASDVGGIPEVVADGITGSLVHYDADDATGYQARLAEAVNALVADPATAERYGHAGRQRCIQEFSWAYIAEQTLDIYRKVCA
What is the function of this protein?
Involved in the biosynthesis of the maltose-1-phosphate (M1P) building block required for alpha-glucan production by the key enzyme GlgE.  Catalyzes the formation of an alpha-1,4 linkage between glucose from ADP-glucose and glucose 1-phosphate (G1P) to yield maltose-1-phosphate (M1P).
What are the official names of this protein?
Alpha-maltose-1-phosphate synthase, M1P synthase, ADP-alpha-D-glucose:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase, M1P-producing glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family.
Protein: GLGB_CORJK
Sequence: MNHDYHRLAERRHHAPHDVLGAHENGDGTTTIRTVQCGAESVAVRINGGEPVQMVPAEEYPALFTATVDYFVDTYNFEVTWAGGTAATLEDPYRRLPTVGDLDRYLIGEGRHEELWKVLGAHVVDGGVAFSVWAPHAAGVSVIGDFNGWNANQHPLRALGSSGIWELWIPSVSAGAHYKFSITTGDGVRLDKADPMARLAEPAPATASIVVADSDYAWGDDEWLAHRAAVGVDETMSIYEMHLGSWRKGRSYRELAVELVEYVQELGYTHVELMGVSEHPFEPSWGYQVTSYYAPNNRYGGPDDLRYLIDSLHRAGIGVIMDWVPGHFPKDGWALGRFDGEACYEHPDPRRGEQPDWGTYVFDFGRNEVRNFLVANALYWCKEFHIDGLRVDAVASMLYLDYSRDDWLPNQYGGRENLDAVEFLKEMNATVHRECPGSLTIAEESTSWPGVTAPTSEGGLGFSLKWNMGWMHDSLEYIQRDPAYRSYHHNEITFSMVYAYSENYVLPISHDEVVHGKGTLWSRMPAGSAWDKAAMVRSYLAFMWAHPGKKLLFQGQEWGQTEEWNESRGLDWHDLEGWEGEFHRGISALTSQLNKLYHSELALGQDHAPEGFQWIASDDSTNNVLSFIRRHRGRELACVINFSGTTQENYRIGLPQAGTWREVLNTDDVQYEGAGRVNGDLHTEPTGSHGMEASAVLQIPAHTARWFVLES
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: YL113_MIMIV
Sequence: MRNISNRERRNKDCLKLIEKNFSNNVLLSQIEAKNAYQRFIEKQIKGLSIAAFIVQDYDYTEIKVKYYRKQKIAWKIFFDQLKNDINLTDHNLILQDQFKKQLMLTSKKDPKCLERFINSLKELGLYNKYKKTMSNLNNKQIKTYANLLFSIYENKEIRSEIKLRVLKNVILQLPIIFDCISK
What are the official names of this protein?
Uncharacterized protein L113.
Protein: RPOE_STAA8
Sequence: MKIQDYTKQMVDEKSFIDMAYTLLNDKGETMNLYDIIDEFRALGDYEYEEIENRVVQFYTDLNTDGRFLNVGENLWGLRDWYSVDDIEEKIAPTIQKFDILDADDEEDQNLKLLGEDEMDDDDDIPAQTDDQEELNDPEDEQVEEEINHSDIVIEEDEDELDEDEEVFEDEEDFND
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: EXD2_HUMAN
Sequence: MSRQNLVALTVTTLLGVAVGGFVLWKGIQRRRRSKTSPVTQQPQQKVLGSRELPPPEDDQLHSSAPRSSWKERILKAKVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGLCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDYGLVVRGCLDLRYLAMRQRNNLLCNGLSLKSLAETVLNFPLDKSLLLRCSNWDAETLTEDQVIYAARDAQISVALFLHLLGYPFSRNSPGEKNDDHSSWRKVLEKCQGVVDIPFRSKGMSRLGEEVNGEATESQQKPRNKKSKMDGMVPGNHQGRDPRKHKRKPLGVGYSARKSPLYDNCFLHAPDGQPLCTCDRRKAQWYLDKGIGELVSEEPFVVKLRFEPAGRPESPGDYYLMVKENLCVVCGKRDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDPERRQVRSGARALLNAESLPTQRKEELLQALREFYNTDVVTEEMLQEAASLETRISNENYVPHGLKVVQCHSQGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKFGEDLPIQLS
What is the function of this protein?
Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291).  In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291).  Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528).  Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466).  Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646).  Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646).  Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466).
What are the official names of this protein?
Exonuclease 3'-5' domain-containing protein 2, 3'-5' exoribonuclease EXD2, Exonuclease 3'-5' domain-like-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the EXD2 family.
Protein: RL29_SYNJB
Sequence: MPMPKIADARALSDEELSNEIYAVKKELFELRLQQATRQLNQPHLIRLRKHKLAQLLTVEGERKRGKRPTKEE
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: MA2B2_MOUSE
Sequence: MGPLRWLPLLGQLLLLWPRAAQPAGPIRAFVVPHSHMDVGWVFTVQESMRAYAANVYTTVVAELVRGGQRRFIAVEQEFFRLWWDGVASEQQKQQVRQLLHEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQFSWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQMLQFVWHGSPSLSGQQEIFTHVMDHYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTGANIHLYAEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLDYINQRTAQFGISVQYATLNDYFQALHATNMTWGIRDHQDFLPYSSEPLQAWTGFYTSRSTLKGLARQASALLYAGESMFTRYMWPDPSGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYTEHLRMGMLGVRKLMVSIALGGPPGSGTGAPKDIMGPQVTPVLSVDTRPVGYSASVYNPLAWKITTIITLTVAFPNVSVTDELGHPVSTQIQNSTKDPSAYDLLILTTIPGLNYRHYQVMHARGDQAGTRELVAPRANTLKFSLKLRNQPSQEGKRLVPVMNDCYILLFDQDTNMLHSIQDRQSNRTVRMTQEFLEYQANWDVKQGPISDNYLFAPNNTAEPSWEAVGMEMVAGTLVTDIRQYFYRYITDQEYIYSIHTRLAHPSLAGELLCQRIEQQYRVGPLDLNREAILRTSSDLNSQQVLYSDNNGYQMQRRPYKAFKSNPIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQGNGQVEVMLHRRLWNNLAWDLKYNLTLNDTSIVHPVLWLMLGPKSTMTALHPRSGVALQHGPVVLLKELADEETPVHGPHNPWPVTLPPNLHLQILSVPGWTYSRSHAQHLRNLQRGHPEKPQANLQRVLLRLRHLYEAGEDPVLSRPATVDLKVVLRGLGSVVAVEERSLTGTWDVQMLQRWHWSTKTDHLKGHPTSPPRPPGGSIITVYPKEIRTFFIKFQQ
What is the function of this protein?
Plays an important role in the early step of spermatogenesis.
What are the official names of this protein?
Epididymis-specific alpha-mannosidase, Mannosidase alpha class 2B member 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 38 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACMA_LACLM
Sequence: MPVSRVKVKNRHLKKKTKKPLAFYKPATKFAGAVLIAGTLTTTHELLLQQTSPMVQAATNSSEVFIESIAASAKPVADANGLYPSVMIAQAILESNWGSSQLSRAPYYNLFGIQGTYQGKSVVFKTQEYLNGKWVTKDMPFRVYPSFNQSFQDNAYVLKTTNFGNGPYYAKAWRANAATYQDATAALTGRYATDPSYGASLNRIISQYNLTRFDGASSAGNTNSGGSTTTITNNNSGTNSSSTTYTVKSGDTLWGISQRYGISVAQIQSANNLKSTIIYIGQKLVLTGSASSTNSGGSNNSASTTPTTSVTPAKPTSQTTVKVKSGDTLWALSVKYKTSIAQLKSWNHLSSDTIYIGQNLIVSQSAAASNPSTGSGSTATNNSNSTSSNSNASIHKVVKGDTLWGLSQKSGSPIASIKAWNHLSSDTILIGQYLRIK
What is the function of this protein?
Hydrolyzes the cell wall of L. lactis and M. lysodeikticus.  Required for cell separation during growth.
What are the official names of this protein?
Probable N-acetylmuramidase, Autolysin, Lysozyme, Peptidoglycan hydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 73 family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROC_XANC8
Sequence: MGSNSFGRLFTVTTFGESHGPAIGCVIDGCPPGLEIAPEEFTHDLQRRATGKSRHTSARREADEIEILSGVYEGRTTGTPIGLLIRNTDQRSKDYTNIAQQFRPGHADYTYWQKYGIRDPRGGGRSSARETTMRVAAGVIAKKWLKQRYGVLVRGFLSQLGEIRPSGFDWDAVEDNPFFWPHAAQVPELETYMDALRKSGDSVGARVDVVAGGVPPGWGEPIYGKLDSELAAALMSINAVKGVEIGDGFASAAQKGTEHRDLITPEGFLSNHAGGILGGISTGQAVTASMVLKPTSSLRLPGATVDADGAVVDVITTGRHDPCVGIRATPIAEAMMALVLMDQALRHRAQCGDVGEVSPLIPGQADV
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: FABZ_GEOSW
Sequence: MLDIQQIQAIIPHRYPFLLVDRILEIEEGKRAVGIKNVSANESFFVGHFPEYPVMPGVLIVEALAQVGAVAMLKKEENRGRLAFFTGIDNCRFKKQVKPGDQLRLEVEIIRAKGPIGKGKGVATVDGELVCETEIMFALGDKKND
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_CAUVC
Sequence: MMNANRLPTRILGLDPGLRRTGWGVLAVEGSRMTHIAHGVITPDEKAEFADRLLHLFEGITAVIEQHRPDEAAVEEVFLNTNAQSTLKLGHARAAALIAPARAGLLVAEYSTRLVKKAVVGTGAADKAQIGFMIARLLPTAGKTTADCADALAVAITHANLRVANRRVA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.