PharMolix/UniProtQA huggingface dataset:
Protein: RS19_THEGJ
Sequence: MARKKEFRYRGYTLDELLNMSLEEFAKLLPARQRRSLKRGLSPEQKKLLRKIRLAKKGKYNKPIRTHSRDMIVLPEMVGITIHVHNGKEFVPIEIKPEMIGHYLGEFALTRKIVQHGSPGVGATRSSMFVAVK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: BSP1_YEAST
Sequence: MTKYERDPELVNFLSKVEDLNSKRYSNIPSSKPAGEALSPVRSHNSGEYRRADMMTGKNVEGCDNLAYRSAYNYEMTFSPKKTHYSLSELNLERITPRPDLEGSASQKEKKFLISEEDYLLLQKLKASQTYNDSNADKNLPSFEKGPRMPSRGRPRPREKEIITIQYDFELPGRADIPSSSSSSSPPPLPTRRDHIKITDGNEEKPLLPTRPNKAEVTESPSSRSIKPDAVVPERVKPAPPVSRSTKPASFLSSLEDNKLTKAKSYNSEMETPKTTVKSSHIDYLDSIQLKPTTLSPTMKNKPKPTPPSPPAKRIPRSESFIKSMLNSNLTTTSKPSLPEKPQKLRNANLAAHKTKPSIPPKKVELNIVLPELRPVETSPTKQNFENSIDLPKLRSSNRNIKKEEEDSIPEAIKGIQNLKKTKQQKPAIPQKKSFLTNNSKNTTLKNGDDINKLNDEIEALSLRNNLKKRPPTAPQRKISLPEALRKVELMKKSKTEPVLESSNELSINAKLDAIIASRNLRASNTLPELSGVNTNIATSDKYTTSRDETVKETKPLVHPNKNRTRGPRRKLPTRV
What is the function of this protein?
Cortical patch protein involved in endocytosis.  May serve as an adapter to link INP52 and INP53 to the cortical actin cytoskeleton.
What are the official names of this protein?
Protein BSP1, Binding of synaptojanin polyphosphoinositide phosphatase domain protein 1.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, actin patch. Note=Peripheral membrane protein in a PtdIns(4)P and PtdIns(4,5)P2 manner.
Protein: LYS5_CAEEL
Sequence: MKHFFITILLFCSVVSAARNGIDINSPVSTSTFTCIKNAGFSFIIPRIYHSSGSVDTVGVQNVKNARAAGLTDVDGYIFPCLKSTCASAANQVKASLDAVKAAGTKISTLWLDIERLNWPADHASNRAFIEAMVSEAKAYGQQVGIYSNYYNWQDIVGLDYHGQSSLMLWWPAYDGVKDFSKYAPFGGWSKPTIHQWSDTTTGPCGVSVDMNYIP
What is the function of this protein?
Plays a role in resistance to Gram-positive bacteria S. aureus or B. thuringiensis infection.
What are the official names of this protein?
Lysozyme-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 25 family.
Protein: NHAB_ALCBS
Sequence: MSATLGRAFVQNFLGQAPAWYKYTIVAFLLINPLVALTLGPVTAGWLLLAEFIFTLAMALKCYPLQPGGLLAIEAVMIGLTSAETVLHKVVGNIEVMLLLIFMVAGIYFLKDLLLFMFTRILLGVKSKVTLSLLFCAAAALLSAFLDALTVTAVVIAVCTGFYGIYHKVASGKTFQQKHDHGDDTTVEELHREDLRRFRSFLRSLLMHAAVGTALGGVCTLVGEPQNLLIANKAGWEFGEFFLRMAPITLPVLVMGFFTCAFLEFSGSFGYGEDIPEKVRGIMRQYALEQDRKRTPQNRAALVIQAITAVWLVIGLATHAASVGLVGLTVIILATSFTGIIEEHRLGAAFEEALPFTALLTVFFAVVAVIADQQLFAPVIEYVLSLEKQVQGPAFYMANGILSAVSDNVFVATVYVDEVGQALLKNEIDRDTFDLLAVAINTGTNIPSVATPNGQAAFLFLLTSALAPLVRLSYGRMVIMALPYTIVMSITGLVMTATVLEPATDYLYENGWIQHHQVEDLQETPLIPGH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS7_STRA5
Sequence: MSRKNQAPKREVLPDPLYNSKIVTRLINRVMLDGKRGTAATIVYDAFEAIKEATGTDALEVFETAMENIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLRWLVNASRARGEHTMKDRLAKEIMDAANNTGASVKKREDTHKMAEANRAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: Y3542_TERTT
Sequence: MPSFDIVSEIDNQEVRNAVENAQRELETRFDFRGVEASFEWTSKETTLSAEADFQLQQMLDILRNKLIKRNVDPDTMEVGDPEHSGKTFSQKITFLEGIDAPTAKKLVKLIKDSKLKVQASIQGDQVRVTGKKRDDLQAVMALVREGKLGQPFQFNNFRD
What are the official names of this protein?
UPF0234 protein TERTU_3542.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: RADD_ECOLI
Sequence: MIFTLRPYQQEAVDATLNHFRRHKTPAVIVLPTGAGKSLVIAELARLARGRVLVLAHVKELVAQNHAKYQALGLEADIFAAGLKRKESHGKVVFGSVQSVARNLDAFQGEFSLLIVDECHRIGDDEESQYQQILTHLTKVNPHLRLLGLTATPFRLGKGWIYQFHYHGMVRGDEKALFRDCIYELPLRYMIKHGYLTPPERLDMPVVQYDFSRLQAQSNGLFSEADLNRELKKQQRITPHIISQIMEFAATRKGVMIFAATVEHAKEIVGLLPAEDAALITGDTPGAERDVLIENFKAQRFRYLVNVAVLTTGFDAPHVDLIAILRPTESVSLYQQIVGRGLRLAPGKTDCLILDYAGNPHDLYAPEVGTPKGKSDNVPVQVFCPACGFANTFWGKTTADGTLIEHFGRRCQGWFEDDDGHREQCDFRFRFKNCPQCNAENDIAARRCRECDTVLVDPDDMLKAALRLKDALVLRCSGMSLQHGHDEKGEWLKITYYDEDGADVSERFRLQTPAQRTAFEQLFIRPHTRTPGIPLRWITAADILAQQALLRHPDFVVARMKGQYWQVREKVFDYEGRFRLAHELRG
What is the function of this protein?
RadD contains helicase motifs, suggesting it may be a helicase, although that activity has not been observed (Probable).  In combination with RadA is important in repair of double-strand DNA breaks (DSB) (PubMed:25425430, PubMed:25484163).  Has DNA-independent ATPase activity that is stimulated by single-stranded DNA-binding protein SSB.  ATPase is stimulated by a peptide with the last 10 residues of SSB, but not when the peptide's last Phe residue is missing.  Binds ssDNA; binding is slightly better in the presence of nucleotides (PubMed:27519413).  May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps.  Binds to DNA structures with 3 branches that resemble replication forks (PubMed:31665437).
What are the official names of this protein?
Putative DNA repair helicase RadD.
Protein: CRYAA_OTOCR
Sequence: MDVTIQHPWFKRPLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGVSEVRSDRDKFVIFLDVKHFSPEDLTVKVQEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSVSADGMLTFSGPKVQSGLDAGHSERAIPVSREEKPSSAPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.  Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein: HISZ_NEIMA
Sequence: MQTWQLPEHIADVLPTNARQLESAREQLLALFRVHGYELVQPPLMEYAHSLLTHIDAGLSLKTILVTDRLSGRQLGIRADITPQVARIDAHLLSANQGINRLCYAGPVLHAQSDGLLNMREPLQAGAEMYGFADIRGDIELIDLMLKSMKIADMGKVLLSLGHIGIFRALSDAAHLDAGQSATLLALMQDKDTETVEAQVKAWKLDGMWAKAFSLLPRLYGGREVLSDARGRLPDLSAVGGALGELQAVCDAFPDCEIHIDLSELRVDNYHTGLLYAAYAADFHDAVARGGRYDGLGGYFGRARPATGFSFDLRSFIGRLPAIERQPAVLVDAEDAEAAHEAVEALREQGQCVVIDYGIGHNVSEELAGRLKKTDGVWQVVKR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESR1_HUMAN
Sequence: MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
What is the function of this protein?
Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726).  Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861).  Binds to ERE and inhibits isoform 1 (PubMed:10970861).
What are the official names of this protein?
Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=A minor fraction is associated with the inner membrane. SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single- pass type I membrane protein. Note=Associated with the inner membrane via palmitoylation (Probable). At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. SUBCELLULAR LOCATION: Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
Protein: BIOD_GRAFK
Sequence: MPKSYFITGIGTEVGKTVVSAIVAEALKADYWKPIQAGDLENSDSHKVKKLVSNKDSVFFKNACALNTPMSPHAAAEIDGIKLQIKNIKRPETEKDLVIEGAGGLMVPLNAKEVIADLISKEDLVILVSRHYLGSINHTLLSIEALKSRGIDKIGIIFSGDEHPTTEAAIKKLGKVKVVGRIEEEPYFDEMVVKEYAEKFRKRLCEI
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2194_PSEA6
Sequence: MIMTTTPSIEGKKIERYCGIVVGEAVMGANVFRDIFAAIRDVVGGRSGAYEDELTNARQIGFRELEAEARSMGANAVVGIDIDYEVVGKGGSMLMVSISGTAVSCSDL
What are the official names of this protein?
UPF0145 protein Patl_2194.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: ULAG_SALEP
Sequence: MSKVQSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCVDFWCGTGKQSHGNPLMKTGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHNDHIDVNVAAAVMQNCADDVPFIGPQTCVDLWVGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGVLPDGMDVRAVNYLFKTPGGNLYHSGDSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADILRMAESLNTKVVIPFHHDIWSNFQADPQEIRVLWEMKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL
What is the function of this protein?
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P.  Is essential for L-ascorbate utilization under anaerobic conditions.
What are the official names of this protein?
Probable L-ascorbate-6-phosphate lactonase UlaG, L-ascorbate utilization protein G.
What is the protein family that this protein belongs to?
Belongs to the UlaG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP7Q_ARATH
Sequence: MSVVGFDVGNENCVIAVAKQRGIDVLLNDESNRENPAMVSFGEKQRFMGAAAAASATMHPKSTISQLKRLIGRKFREPDVQNDLRLFPFETSEDSDGGIQIRLRYMGEIQSFSPVQILGMLLSHLKQIAEKSLKTPVSDCVIGIPSYFTNSQRLAYLDAAAIAGLRPLRLMHDSTATALGYGIYKTDLVANSSPTYIVFIDIGHCDTQVCVASFESGSMRVRSHAFDRNLGGRDFDEVLFNHFALEFKEKYNIDVYTNTKACVRLRASCEKVKKVLSANAEAQLNIECLMEEKDVRSFIKREEFEQLSAGLLERLIVPCQKALADSGLSLDQIHSVELVGSGSRIPAISKMLSSLFKRELGRTVNASECVARGCALQCAMLSPVFRVRDYEVQDSYPFAIGFSSDKGPINTPSNELLFPKGQIFPSVKVLTLHRENTFQLEAFYANHNELSPDIPTQISSFMIGPFHISHGEAARVKVRVQLNLHGIVTIDSATLIEYHKENITSEEMISEENHQSSAMKDGSLDPSSGSIGNEPKAIKRMEIPVVANVSGALTKDELSEAKQRENSLVEQDLKMESTKDKKNALESFVYEMRDKMLNTYRNTATESERECIARNLQETEEWLYEDGDDESENAYIEKLNDVKKLIDPIENRFKDGEERVQASKDLLKTIADNRMAAESLPPPRKNAVLDECHKAERWLHEKTTEQESLPKDANPELQSAEIRRKADALNATCKYIGKSNSPPAKPEHNGSYGSRKSDDMELD
What are the official names of this protein?
Heat shock 70 kDa protein 16, Heat shock protein 70-16, AtHsp70-16.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 (TC 1.A.33) family. HSP110/SSE subfamily.
Protein: LEU3_SODGM
Sequence: MMSKTYHIAVLPGDGIGPEVMAQAYKILDAVRQRFNVRISTSEYDVGGAAIDRQGSPLPAGTVAGCEQADAILFGSVGGPKWEHLPAAEQPERGALLPLRKHFKLFSNLRPSRLYPGLEAYCPLRANIAERGFDILCVRELTGGIYFGQPKGREGTGPHEHAFDTEVYYRFEIERIARIAFESARKRRGKVTSIDKANVLQSSILWRKVVSQVAPDYPDVALSHLYIDNATMQLIKDPSQFDVMLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGMYEPAGGSAPDIAGKDIANPVAQILSASLLLRYSLGLDDAADAIELAVNQALEAGHRTADLAGGGSAVGTGEMGDIIAALISQGA
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METJ_ECODH
Sequence: MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMREMGINPETWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTC_MYCA1
Sequence: MTPRHFLRDDDLSPAEQAEVLALAAELKKDPFSARPLEGPRGVAVLFDKNSTRTRFSFEVGIAQLGGHAVVVDARSTQLGRDETLEDTARVLSRYVEAIVWRTFEQHRLEAMAGAATVPVINALSDEFHPCQVLADLQAIAEHKGSLSGLRMCYLGDGANNMAHSLMLGGVTAGIHVTIAAPDGFTPAPEFVAAARRRAESTGATVTLTTDARTAARGVDVLVTDTWTSMGQEDDGLDRRTPFWPYQLNADLVSLADPEAIVLHCLPAHRGEEITDEVMDGPSSVVWDEAENRLHAQKALLTWLLERQA
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAKD5_MACFA
Sequence: MAATLKSLKLLRYRALCSPSACGAARSVSYWNVSSKQHGGQDPPEHISLCHSAKRVKNICSTFSSRRILTTSSACPGLEFSKTSSSKASTLQLDSPRATRVDEEDVEVFDSFANIRVFLQLRPEYRVHSYNASETSQLLSVSESELILHKVTVYQNKLQAQVIVDYLCKLSSLPAEQHPVLLRSTSFALLCQLSVKKIQLFDTQDLINVLKAFVILGIPHSHSMLDVYETKCCHQVWEMSMDQLLLVADLWRYLGRKIPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIGENRQVSQDLMQKLESLILKYIDLINLEEVGTICLGFFKSKTSLSEFVMRKIGDLACANMQHLSSHALVNIVKMFRFTHVDHINFMKQLGEIAPQRIPSLGVQGVMHLTLYCSALRFLDEGVMNAVAASLPCRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLINEIHRKMPEFNQYPEHLPTCLLGLAFSEYFPVELIDFALSPGFVRLAQERTKFNLIKELYTLDGTVGIECPDYRGNRLSTHLQQEGSEFLWNLAEKDMNSKPEFLETLFLLETMLGGPQYVKHHMILPHTRSSDLEVQLDVNLKPLPFNREATPAENVATLRLKHVGVSLTDDLMNQLLKGKARGHFQGKTESEPGQQPMELENKAAVPLGGFLCNVADKSGAMEMAGLCPSACMQTPGMKLAIQFTNRNQYCYGSRDLLGLHSMKRRQLARLGYRVVELSYWEWFPLLKRTRLEKLAFLHEKVFTSAL
What is the function of this protein?
Plays an important role in the processing of non-canonical mitochondrial mRNA precursors.
What are the official names of this protein?
FAST kinase domain-containing protein 5, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the FAST kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids.
Protein: UREG_STAA3
Sequence: MANPIKIGIGGPVGAGKTQLIEKVVKRLSKEMSIGVITNDIYTKEDEKILVNSGVLPESRIIGVETGGCPHTAIREDASMNFAAIDELLERHDDIELIFIESGGDNLAATFSPELVDFSIYIIDVAQGEKIPRKGGQGMIKSDFFVINKTDLAPYVGASLEQMAEDTKVFRGKRPFTFTNLKTDEGLDEVIDWIERDTLLKGLS
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBQL1_PONAB
Sequence: MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLLSNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTAPNLVPGVGASMFNTPGMQSLLQQITENPQLMQNMLSAPYMRSMMQSLSQNPDLAAQMMLNNPLFAGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSNPRAMQALLQIQQGLQTLATEAPGLIPGFTPGLGALGSTGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAGVNPQLQNPEVRFQQQLEQPSAMGFLNREANLQALIATGGDINAAIERLLGSQPS
What is the function of this protein?
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway.  Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome.  Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome.  Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress.  Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion.  Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway.  Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization.  Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination.  Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing.  Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (By similarity).
What are the official names of this protein?
Ubiquilin-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endoplasmic reticulum. Cytoplasmic vesicle, autophagosome. Cell membrane. Note=Detected in neuronal processes and at synapses. Recruited to the ER during ER-associated protein degradation (ERAD). Colocalizes with PSEN1 in the cell membrane and in cytoplasmic juxtanuclear structures called aggresomes. Colocalizes with ORAI1 and TICAM1 in the autophagosome. Colocalizes with EPS15 and HGS in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and with EPS15 also in aggresomes.
Protein: RL30_LUPLU
Sequence: MVAAKKTKKTHESINNRLALVMKSGKYTLGYKTVLKSLRSSKGKLIIIANNCPPLRKSEIEYYAMLAKVGVHHYNGNNVDLGTACGKYYRVCCLSIVDPGDSDIIKTLPGDQ
What are the official names of this protein?
60S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
Protein: CYB_ANTVP
Sequence: MAPNIRKSHPLLKMMNNSLIDLPTPSNISDWWNFGSLLGICLATQILTGLLLAAHYTADTTLAFSSVAHTCRNVQHGWLIRNLHANGASFFFICIYLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAVPYIGQTLVEWAWGGFSVDNPTLTRFFTLHFLLPFMIMGLTLIHLTFLHESGSNNPLGIVSNCDKIPFHPYFSLKDILGFMLMLFPLMTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYLLFAYAIRRSIPNKLGGVLALAASVLILFLAPLLHKSKQRTMTFRPFSQLLFWTLAANLLILTWVGSQPVEHPFIIIGQLASLTYFTILLILFPIIGALENKMLNY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TIG_CLONN
Sequence: MNTKIERVENNVVKLEITVEKEKFNEAIKKAYKKNVKRFNVPGFRKGKAPMNIITRYYGEGVFYEDAINTCCEEAYPMAVEEHNLQPVDYPKIDIVEIGSGKDFVFTAEVVTRPEVKLENYKGVEAKKNTYEVTDEDVEKQLNAMLEKNARIITKEEGAAVQKNDIAIIDFKGFVDGKAFEGGEATDYSLEIGTGTFIDNFEDQLVGLKVGEEKEVNVNFPEQYGREELNGKPAKFEVKIKEIKVKELPALDDEFAKEVSEFDTVDALKADLKTKLEEANKNREKVEYEEAVIEEVCNRAEVEIPEVMIEKEIDMMLKDLEMRLGYQGLDLASYYQYTNSSEAKVREYMKETAEKKVKTELVLEKIVKDEKIEATEEEIKERAKEMAQQYGGGQDADKLVEAIVGAQREVLARQLANEKAIDFLVENSKEIA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: SYP_STRP8
Sequence: MKQSKLLIPTLREMPSDAQVISHALMVRAGYVRQVSAGIYAYLPLANRTIEKFKTIMREEFEKIGAVEMLAPALLTADLWRESGRYETYGEDLYKLKNRDNSDFILGPTHEETFTTLVRNAVKSYKQLPLNLYQIQSKYRDEKRPRNGLLRTREFIMKDGYSFHHNYEDLDVTYEDYRQAYEAIFTRAGLDFKGIIGDGGAMGGKDSQEFMAITPARTDLDRWVVLDKSIASMDDIPKEVLEEIKAELAAWMISGEDTIAYSTESSYAANLEMATNEYKPSSKVAAEDALVEVETPHCKTIDEVAAFLSVDETQTIKTLLFVADNEPVVALLVGNDHINTVKLKNYLAADFLEPASEEEARAFFGAGFGSLGPVNLAQGSRIVADRKVQNLTNAVAGANKDGFHVTGVNPGRDFQAEYVDIREVKEGEMSPDGHGVLQFARGIEVGHIFKLGTRYSDSMGATILDENGRAVPIVMGCYGIGVSRILSAVIEQHARLFVNKTPKGDYRYAWGINFPKELAPFDVHLITVNVKDQVAQDLTAKLEADLMAKGYDVLTDDRNERVGSKFSDSDLIGLPIRVTVGKKAAEGIVEIKIKATGDSIEVNAENLIETLEILTKEH
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.