Protein: MIX1_CAEEL
Sequence: MHIKSIHLDGFKSYQKHTDILDFSPTFNAITGYNGSGKSNILDSICFIMGINKLDNIRAKSMHELISHGGTKAIVQVRFDNTDKRCSPFGMEHLDEIVVQRIITAQATGKGCATSYTLNGHAATNGKMQDFFRGVGLNVNNPHFLIMQGRITTVLNMKPEEILGMVEEAAGTKMYDQKKKDAEKTMFLKDAKLKEVDRIFQSSIDPRMVKFREDRKNMVEVTRLKKLKENFSRKYEAFQYFQTCEAVKKSAKEIEDAKKGIEDLGEKFNQLDLDLKNKEDEKKKMEESRDDQHEEAALSAAHLSKQSIMLQKETVKNQLVETINKLKKEGEQINKSLSKDREVLDAKRKEHEDSKAANSKDIQSQSDDEALVTKYRNDLESLTRGTIANDKGEHVSIESEIQSCKSTASQMSSGITAAKKRGERLHNQIKHLEGEKATLSARSKSDIGSADNYQKEVDEINKQLQLLGFNIDADTEKREHAAKLHESITKLKDMDTRLLNSYKDGRYALNYQRPPLHIDKFDEKRDVFGYVAHLIKMKPGCEQFAVAADIALGGVLGNVVVSTQDIARILIDGKAFTSRKTMIPVSENARNASSYNTLPDVKLRRAKEIAEKYNDTVTKMIDLIEYPDFISNTILNAVGQILVVDSLDVAREIAYDEVAKTRMITRRGDDVRTNGIMTGGYNDPGNKPALIALEPMYARRPQIEAQQRELDALNRELQLTEASSQKCRDLNNQLATAMRKLAQVKTNINNSEFGIVVRDLKVHSEEYEKNQAEIEATVKTLKDVEDKIKTLESMKNKDKNSQEKRKKELTALLQKAEQTVAQNKNRGEKARREVMLLQATVEEMEKTIKKDEGIWEQKKKECDELEEKLPNAIAALKDAELEQKAAQAKLNDLKNNQRQISTRLGKIAKECDALIREKAKTKSKREEKEKELTSLQQSEASNRKEARSKLKKFEWLSDEEAHFNKKGGLYDFEGYTVSKGKDEIKELTDKIETLERSCCIQNVSNLDTCEAKVLDIKNKRERITEDFNMLKKTIATLDKKKVDELIRAHESVNKDFGQIFNCLLPDAHASLVPPEGKTVCEGLEVKVSFGGVVKDSLHELSGGQRSLVALSLILAMLKFKPAPLYILDEVDAALDLSHTANIGMMIKTHFHHNQFIIVSLKQGMFSNADVLFQTRFADGHSTCTRLNGGDIAVLCQDKVLQAQALELTDAGKAKKDAAAKKGAQKNDKEPPKKKPIVVDDDDFE
What is the function of this protein?
Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners (PubMed:9458050, PubMed:11914278, PubMed:19119011, PubMed:18198337, PubMed:19781752).  Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes (PubMed:11914278, PubMed:18198337, PubMed:19119011).  The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases (PubMed:11914278).  Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity).  Central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation and organization (PubMed:19119011, PubMed:15557118).  Both the condensin complex I and II play a role in meiotic and mitotic chromosome segregation (PubMed:11914278, PubMed:19119011, PubMed:15557118).  Plays a role in robust cytokinesis upon the presence of chromatin obstructions (PubMed:23684975).  Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase (PubMed:9458050, PubMed:19119011, PubMed:18198337, PubMed:19781752).
What are the official names of this protein?
Mitotic chromosome and X-chromosome-associated protein mix-1, Lethal protein 29, Structural maintenance of chromosomes protein 2.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=During mitosis and meiosis, localizes to condensed chromosomes in both sexes (PubMed:11914278, PubMed:19119011, PubMed:15557118). During meiotic prophase, surrounds the chromosomes, localizes between homologs during meiotic metaphase I, and localizes between sister chromatids during metaphase II (PubMed:11914278). During mitotic metaphase, localizes at the poleward face and to the core of the condensed chromosomes (PubMed:19119011, PubMed:18198337, PubMed:15557118). Requires hcp-6 for the localization to meiotic chromosomes (PubMed:15557118). After the 40-cell stage when dosage compensation is initiated, specifically localizes to the hermaphrodite X chromosomes in interphase (PubMed:9458050, PubMed:11914278).