PharMolix/UniProtQA huggingface dataset:
Protein: NPIIF_ARTGP
Sequence: MQFFTAIAAISALVAPALALPTQELPQAPTNQTLHVRLIPTGNTMVKAVVTNNGDRPLNLLKFNTIMDENPTAKVNVVHEDGEEVEFTGMLPRYSMRSLPKSVFTRLAPKDSVEHVFDIATVHNLKRSGKYTLSARGAVPVAEGDDTAIIDHVYYQSNDLTMEIDARKAALIPRAFEDTHFAGTLNRRGGLNSTCSPRRYQVIKRALNDARMIASSASKAVSSNPEKFREFFGTTDPNAMKQVSERLMAIAQASVENGPIKWHCFDSRGRCEQNVVAYTLPSRNEVFPCMPFFTESDFTNKCHAQDKPTTLIHEAAHNPSVVQPFCRDHGYGYDHVSRLPPRLALQNADNYSIYAQGKFHLHLPLKVVFSPN
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Shows high activities on basic nuclear substrates such as histone and protamine.  May be involved in virulence (By similarity).
What are the official names of this protein?
Neutral protease 2 homolog MGYG_06241, Deuterolysin MGYG_06241.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPD_AROAE
Sequence: MQNFQPRHFAIVPAAGSGSRMATSRPKQYLPLLGKPLIFHSLAVLCAAPDVDKVFVVLSVEDAEWRRHDWSVLGPKLVPLFCGGGTRADSVLAGLRAVADEIEPSDWVLVHDAARPCLAPWHIEKLARELARDEVGGLLAVPVADTLKRADEHRQVLATVPRENLWQAQTPQMFRHVMLRRALEAATNATDEASAIEAAGLHPRLVESDATNLKVTYPLDLHLAEWILTNRGS
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: PIMT_YERPB
Sequence: MVNKRMQTLLMQLRQQGIHDERLLQAIEAVPRERFVDEALAHKAYENTALPIGAGQTISQPYMVARMTELLQLTPTSRVLEIGTGSGYQTAILAHLVDHVCSVERIKGLQWQAKRRLKQLDLHNVSTRHGDGWLGWQSRGPFDAIIVTAAPPEIPDALLEQLDEGGILVLPVGEQFQTLKYVQRRNNEYHIETVEAVRFVPLVKGELA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y0569_BRAHW
Sequence: MNSIYAFANQNIIRVQLTDVKAPYTINIKGPYKAYNYKYESEIISALTNETVMVVENRLGLKVNEVGVYKEGIVFETQDGFTLNGIEYYGSLMFIPYNDTMIVVNELNIEDYVKGVLPHEMSPDWPMEALKAQAVAARTYAMYHILKNANKLPFDVDNTTKYQVYNGKEKMNWSVEQAVDRTRYEIAVYKGKVIATYFSALCGGHTDSAENVFGVAVPYLGGVACPYCNAQIKPWTNALSYNELNNDLANYSVHATEKSSIGISTDPKSGKATNIKIDNNDITSRDFRTTLSPRLVPSLNFTIKKVDNGIIITGKGSGHGVGMCQWGAYGMAQVKKDYKEILKFYYNGVDIVDYNRVNKEFEPDVWGN
What is the function of this protein?
Might be involved in sporulation.
What are the official names of this protein?
Uncharacterized protein BHWA1_00569, H-34.
Protein: LAC1B_CERUI
Sequence: AIGPVADLH
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products.
What are the official names of this protein?
Laccase-1b, Benzenediol:oxygen oxidoreductase 1b, Diphenol oxidase 1b, Lac Ib, Urishiol oxidase 1b.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL36_LEPCP
Sequence: MKVSASVKKICRNCKIIRRKGVVRVICTDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: CSN4_DICDI
Sequence: MDVNNLKQILEETSALSDHKTKTEKYKSILQQLVESKQVAPLKVFITHLTDESTPLVISRTILLSFTSSHKTLPEDIQMELGIFVLDRIQNRVVAFEEQVSEIRYNLAKLYERQENWRESARCLIAIPLDSSQRVISPEYKVKIYVKIARLFLEEEESGQAETYINRASDSLHLVKNQKLILAHKTCFARIMDYKRMFLKASLRYYDLSQCLPKDTERMHALSCAIVCAILDKAGPQRSRTLATLYKDERSQQLGVYTFLEKMFLERILKKTEVKKFAEQLKPHQMALLSDGNTVLDRAVIEHNLLSASKLYNNITFDELGSLLEIQAEKAEKVASKMVCEERLIGSIDQIERLIQFENVGDSLTQWDKKIEGLCIHMNNIIESISKYPEFIV
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
What are the official names of this protein?
COP9 signalosome complex subunit 4, Signalosome subunit 4.
What is the protein family that this protein belongs to?
Belongs to the CSN4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRXB_MYCPN
Sequence: MLKVKSDFLTKDQVIYDVAIVGAGPAGIAAGIYGKRANLNLAIIEGSTPGGKVVKTNIVENYPGYKSITGPDLGLEMYNHLIDLEPTFFYANLIKLDKAADTFILYLDDKTVVFAKTVIYATGMLERKLGVAKEDHFYGKGISYCAICDGSLYKDQVVGVVGGGNSAIQEALYLASMAKTVHLIHRREGFRADETALNKLRNLPNVVFHLNYTVKELLGNNTLNGIVLQNTLDHSTKQIDLNCVFPYIGFESITKPVEHLNLKLDPQGFLITNEQMETSLKGLFAAGDCRSKHFRQIGTAINDGIIAVLTIRDVL
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCKG_MYCGI
Sequence: MTAATIPGLDSAPTKHEGLLAWVREVAELTQPDRVAWADGSEEEYERLCAHLVEAGTFQKLNPDKQPNSYLALSDPSDVARVESRTYICSEREIDAGPTNNWMDPAEMRGIMTDLYRGSMRGRTLWVVPFCMGPLNAEDPKLGVELTDSEYVVVSMRTMTRMGAAALEKIGDDGFFVKALHSIGAPLEPGQADVPWPCNDTKYITHFPETREIWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYIAAAFPSACGKTNLAMLQPTIPGWRAETVGDDIAWMRFGKDGRLYATNPEFGFFGVAPGTNWDSNPNAMKTIAAGNTVFTNVAKTDDGDVWWEGLEGEPDHLIDWKGNDWVLRETETKAAHPNSRYCTPISQCPTLAPEWDDPQGVPISAILFGGRRKTTVPLITEARDWQHGVFIGATLGSEQTAAAEGKVGTVRRDPMAMLPFLGYNVGDYFQHWINIGKQADESQLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWAVERIEHKADGKSTPIGIVPTAADLDLSGLDVNAADVDEALDVKVDEWRAELPLIEEWFEFVGEKLPTGIKDEFDALKTRLAEES
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C1QL3_MOUSE
Sequence: MVLLLVILIPVLVSSAGTSAHYEMLGTCRMVCDPYGGTKAPSTAATPDRGLMQSLPTFIQGPKGEAGRPGKAGPRGPPGEPGPPGPVGPPGEKGEPGRQGLPGPPGAPGLNAAGAISAATYSTVPKIAFYAGLKRQHEGYEVLKFDDVVTNLGNHYDPTTGKFTCSIPGIYFFTYHVLMRGGDGTSMWADLCKNNQVRASAIAQDADQNYDYASNSVVLHLEPGDEVYIKLDGGKAHGGNNNKYSTFSGFIIYAD
What is the function of this protein?
May regulate the number of excitatory synapses that are formed on hippocampus neurons.  Has no effect on inhibitory synapses.  Plays a role in glucose homeostasis.  Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake.  In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production.
What are the official names of this protein?
Complement C1q-like protein 3, C1q and tumor necrosis factor-related protein 13, C1q/TNF-related protein 13, CTRP13, Gliacolin.
What are the subcellular locations of this protein?
Secreted.
Protein: HMR2B_PANGI
Sequence: MDVRRRPVTKTLTAGEPLKSQNQHSSSLKASDALPLPLYLTNGLFFTMFFSVMYFLLHRWREKIRNSVPLHVVTLSELAALVLLVASVIYLLGFFGIGFVQSLIRPSPDSWDILEDDNAILEEDSRCEPCAAAIDCSLPPNLKIARMVPQKHKSAFADVVEEQKQSASATIIDEDEEIINAVVAGTTPSYSLESKLGDCLKAAAIRREALQRITGKSLDGLPLDGFDYESILGQCCEMPVGYVQVPVGIAGPLLLNETEYSVPMATTEGCLVASTNRGCKAIYASGGATSVLLKDGMTRAPVVRFGSAKRAAELKFFLEDPMNFETLALVFNKSSRFGRLQGIKCAIAGKNLYMRFTCSTGDAMGMNMVSKGVQNVLDFLQNDFPDMDVMGISGNYCSDKKPAAVNWIEGRGKSVVCEAIIKEEVVKKVLKTNVAALVELNMLKNLAGSAVAGALGGFNAHASNIVSAVYVAAGQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLGVKGASKESPGPNSRLLASIVAGSVLAGELSLMSALAAGQLVKSHMKFNRSSKDVSKLSS
What is the function of this protein?
Catalyzes the synthesis of mevalonate, the specific precursor of all isoprenoid compounds present in plants (By similarity).  Component of the triterpene saponins (e. g.  ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:29378087).  Promotes triterpenes accumulation in roots (By similarity).
What are the official names of this protein?
3-hydroxy-3-methylglutaryl coenzyme A reductase 2-B, HMG-CoA reductase 2, Hydroxymethylglutaryl-CoA reductase, PgHMGR2.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: XIAP_HUMAN
Sequence: MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
What is the function of this protein?
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis.  Acts as a direct caspase inhibitor (PubMed:11257230, PubMed:11257231, PubMed:12620238).  Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (PubMed:11257230, PubMed:11257231, PubMed:16352606, PubMed:16916640).  Inactivates CASP9 by keeping it in a monomeric, inactive state (PubMed:12620238).  Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin.  Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation.  Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation.  Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation.  Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation.  Ubiquitinates and therefore mediates the proteosomal degradation of BCL2 in response to apoptosis (PubMed:29020630).  Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation.  Acts as an important regulator of innate immune signaling via regulation of Nod-like receptors (NLRs).  Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.  Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.  Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES.  Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.
What are the official names of this protein?
E3 ubiquitin-protein ligase XIAP, Baculoviral IAP repeat-containing protein 4, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, RING-type E3 ubiquitin transferase XIAP, X-linked inhibitor of apoptosis protein, X-linked IAP.
What is the protein family that this protein belongs to?
Belongs to the IAP family.
Protein: VM1BJ_BOTJA
Sequence: RYIELAVVADHGMFTKYRVHELVNTVNGFFRSKQDLIKVQKDKTLTSFGEWRERDLLPRI
What is the function of this protein?
Prothrombin (F2) activator that is cofactor-independent.  Also has fibrinolytic and fibrinogenolytic activity.  It degrades the Aalpha-chain and more slowly the Bbeta-chain of fibrin and fibrinogen, while the gamma-chain is only partially and slowly affected.  A dose-dependent procoagulant activity is shown in human plasma.
What are the official names of this protein?
Snake venom metalloproteinase bothrojaractivase, SVMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NBLIK_NOCFA
Sequence: MSDLASEGSDPAERASEHSNGNAPADRPARRSGDQAVADAAERAKATGSRNIPVLPDLPLPEDTANLRLGPDLSPAMLALLPMVGVWRGEGEGNDPARGDYRFGQQIIVSHDGGDYLSWESRSWFIEADGSYGGPDLRETGFWRVGVDGDDEVIELLLTHSSGIVELFYGTALTQSSWELATDVVIRSQSGVVVGGAKRLYGIVEGGDLAYVEERVVADGPLEPRLSARLQRYIG
What are the official names of this protein?
Ferric nitrobindin-like protein.
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: YAC9_MAIZE
Sequence: MTQQLGAMVLTCCTAKCCEPVSSRGDRETADGRMGERRAVEVWRTADRRWRMADGRTADGRAVEWRSGRMGGPRRDGRVASSGVEGGPWMAASASGVPRHGRHRVWCLVQPSGRPAGRQGESERAGESETRVGVGVRLAASGLRRGRVAACECVMLLLVWCLPPGREAEQRSLGISYMGWASVVMDGSWSWPYCSHPELENTVTKRDHPD
What are the official names of this protein?
Transposable element activator uncharacterized 23 kDa protein, AC 23 kDa protein.
Protein: YOO1_CAEEL
Sequence: MKVNEEGFAIDDKEYAMKTELKFASKHSSRLKIERNVMESYSKCDAQCKEHFSELIDFGQSPVWKWIVMTIVGPSLEELKMKYKPSDIPPSTILQCGLQTMKAIHDFHQIGFLHRDIKPANYCIGYGSKSETIYVLDFGLARKYRLPNGQVRPPRPKTKMIGTPRYCSRASHRCEELGRRDDYESWFFMFIDLVDTTLIDWKGLTRPDAYAKKQELFTKLKTYEKHPMFKVISIYLDNLVYDSEVKFGVLREAITDYARGCKLTLKEPLVWFNQSTCPSPSTAPGTGASRMATNIDLKSIASDRNEENSLDRSKTGTLSFNNSKNKKPSRY
What are the official names of this protein?
Putative serine/threonine-protein kinase ZK507.1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: LX12B_MOUSE
Sequence: MATYKVKVATGTDFFSGTLDSISLTIVGTQGESHKQRLNHFGRDFATGAVDDYTVQCQQDLGELIIIRLHKEPHSFLAKDPWYCNYVQICAPDCRVYHFPAYQWMDGYETLALREATGKITADDTLPILLEHRQEEIRAKKDFYHWRVFVPGLPNYVDIPSYHPPPRRCRNPNRPEWDGYIPGFPILINIKATRFLNSNLRFSFVKTASFFYRLGPMALAFKLRGLVDRKRSWKRLKDIKNIFPATKSVVSEYVAEHWTEDSFFGYQYLNGINPGLIRRCTQIPDKFPVTDEMVAPFLGEGTCLQAELERGNIYLADYRILDGIPTVELNGQQQHHCAPMCLLHFGPDGNMMPIAIQLSQTPGPDCPIFLPNDSEWDWLLAKTWVRYAEFYSHEAVAHLLESHLIGEAFCLALLRNLPMCHPLYKLLIPHTRYNVQINSIGRALLLNKGGLSARAMSLGLEGFAQVMVRGLSELTYKSLCIPNDFVERGVQDLPGYYFRDDSLAVWYAMERYVTEIITYYYPNDAAVEGDPELQCWVQEIFKECLLGRESSGFPTCLRTIPELIEYVTMVMYTCSARHAAVNSGQLEYTSWMPNFPSSMRNPPMQTKGLTTLQTYMDTLPDVKTTCIVLLVLWTLCREPDDRRPLGHFPDIHFVEEGPRRSIEAFRQNLNQISHNIRQRNKCLTLPYYYLDPVLIENSISI
What is the function of this protein?
Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:16129665).  Does not convert arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE (PubMed:10100631, PubMed:11256953).  In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins.  Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:17403930, PubMed:17429434, PubMed:21558561).  May also play a role in the regulation of the expression of airway mucins (By similarity).
What are the official names of this protein?
Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type lipoxygenase 12, Epidermis-type lipoxygenase 2, e-LOX 2.
What is the protein family that this protein belongs to?
Belongs to the lipoxygenase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region.
Protein: ATG11_SCHPO
Sequence: MRFRLNDSFSGKSWTIDNVQWTPQNLVAWIMELNIGLSDEAKLLLPNGMSLNETVLNSESDVVIYVLDQNLLTFTYDGDKIPSIPSLKGQPISNVLTGIIADSSSDQWKDKISKCLSLLSDILESSSKIHNQLSVCHDEYSTSIVSPEVAMNYLQRRQSGMKDLLFVFYERLDRVSVSDLLHDFLALPTGSLPITPLKILSTNWTKLDSWLNSISARYAEAQKRVQQCIGAANSIIVSPFKEVPSIKEGDDAYYHLRSVAQDAANILQEILKIESTSTTSQIKPKCNYETEITDCMEKLQSNLSELKSSRKSSLISLKSFWLSFYKVSLRYDALYEYLRQIAEELDRSKFVLSQSRNIFSLYIDILMEALRRTEWQESYNVSHDSSLPLDQEKELSLRKSWLSHFSNLLFNHGQLKYLPVLTRDEISNYLLNIQAHPNYQTFHQMLSNRLSEYLGFPGSPREAVSNTVQANNSLHEKLAMYQNRCNNLEAMLSHQNGFNYNINNDGLSPNAPHPPINEQSNSSQPFYRVSPSIVPLNVIRKLTNRKTSFTDSHILRLQDEVNQLRNELDLVNKRNEDLLIELQGKEEKIQYLETENEEVLQKYENLQEELSSTRKLLTKNEAAVAEQQSNEEMHSNEPNILNLYSVFEGKVDSLQELYNAFKLQLTSLKQKGEYATLAKDAEAVQHIIEERDYALAEKADLLKLSENRKEQCKILTQKLYTIVFRCNELQSVLRECVTQPGFDSDNERDGHASIPDRQIEFNSKDLQYLYWMDGEDADRNFQEFLNRMSSLDFDSFHNFVVSVLTQAHNHELRWKREFQSNRDKALKAILDSQSKVSLRNFKQGSLVLFLPTRRTAGNKKVWAAFNVNAPHYYLNTQPHLKLESRDWMLGRVTSIEDRTADDSTDKWLRLPSGTIWHLVEAIDERF
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy.  Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation.  Works as scaffold proteins that recruit ATG proteins to the preautophagosome (PAS), the site of vesicle/autophagosome formation.  Required for atg9 anterograde transport from the mitochondria to the PAS (By similarity).  Required for nitrogen starvation-induced sexual development and for entering the dormant G0 state (By similarity).
What are the official names of this protein?
Taz1-interacting factor 1, Protein taf1, Autophagy-related protein 11, Cytoplasm to vacuole targeting protein 9.
What is the protein family that this protein belongs to?
Belongs to the ATG11 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Protein: VIAA_SHIF8
Sequence: MLTLDTLNVMLAVSEEGLIEEMIIALLASPQLAVFFEKFPRLKAAITDDVPRWREALRSRLKDARVPPELTEEVMCYQQSQLLSTPQFIVQLPQILDLLHRLNSPWAEQARQLVDANSTITSALHTLFLQRWRLSLIVQATTLNQQLLEEEREQLLSEVQERMTLSGQLEPILADNNTAAGRLWDMSAGQLKRGDYQFIVKYGEFLNEQPELKRLAEQLGRSREAKSIPRNDAQMETFRTMVREPATVPEQVDGLQQSDDILRLLPPELATLGITELEYEFYRRLVEKQLLTYRLHGESWREKVLERPVVHKDYDEQPRGPFIVCVDTSGSMGGFNEQCAKAFCLALMRIALAENRRCYIMLFSTEIVRYELSGPQGIEQAIRFLSQQFRGGTDLASCFRAIMERLQSREWFDADAVVISDFIAQRLPDDVTSKVKELQRVHQHRFHAVAMSAHGKPGIMRIFDHIWRFDTGMRSRLLRRWRR
What are the official names of this protein?
Protein ViaA, VWA domain protein interacting with AAA ATPase.
What is the protein family that this protein belongs to?
Belongs to the ViaA family.
Protein: ARNT_DROME
Sequence: MDEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNSSGKTMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSPTPVAPNSWAALRPQQQQQQQQPVTEGYQYQQTSPARSPSGPTYTQLSAGNGNRQQAQPGAYQAGPPPPPNAPGMWDWQQAGGHPHPPHPTAHPHHPHAHPGGPAGAGQPQGQEFSDMLQMLDHTPTTFEDLNINMFSTPFE
What is the function of this protein?
Heterodimers of tgo/trh are involved in the control of breathless expression.  Plays a role in the cellular or tissue response to oxygen deprivation.
What are the official names of this protein?
Aryl hydrocarbon receptor nuclear translocator homolog, dARNT, Hypoxia-inducible factor 1-beta, Protein tango.
What are the subcellular locations of this protein?
Nucleus.
Protein: IL12B_CAVPO
Sequence: MCHRQLISSWLSLVLLASPLLAMWELKKDVYVVELDWHTDAPGETVVLTCNTAEEDGITWTSDRKSDILGSGKTLTIQVKEFEDAGGYTCHKGGEVLSRSQLLLHKKEDEIWSTDILKEQKGSNGKTFLKCEARSYSGRFTCWWLTAFGTDVKFSVKGSRGSSDPSGVTCGEAERVSGDNQEYKYSVECQEDSACPTAEESLPIEVVVDAIHKFKYENYTSSFYIRDIIKPDPPKNLQLKPSVNSQQVEVSWEYPDTWSTPHSYFSLTFLVQTHGKNKNRREKKYELFTDKTSATVSCHKISKVEVRARDRYYSSSWSEWASVSCSEVSVSR
What is the function of this protein?
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.  IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.  IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines.  IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
What are the official names of this protein?
Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40.
What is the protein family that this protein belongs to?
Belongs to the IL-12B family.
What are the subcellular locations of this protein?
Secreted.
Protein: GP1BB_HUMAN
Sequence: MGSGPRGALSLLLLLLAPPSRPAAGCPAPCSCAGTLVDCGRRGLTWASLPTAFPVDTTELVLTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAEDELRAACAPGPLCWGALAAQLALLGLGLLHALLLVLLLCRLRRLRARARARAAARLSLTDPLVAERAGTDES
What is the function of this protein?
Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.
What are the official names of this protein?
Platelet glycoprotein Ib beta chain, GP-Ib beta, GPIb-beta, GPIbB, Antigen CD42b-beta.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SPED_SALNS
Sequence: MKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPIDPKLIDQTEHPGPLPETVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDVNGMKHFIDHEINSIQNFMSEDMKSLYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTETERQEITAALWKEMREIYYGRNISAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: CLASR_BOVIN
Sequence: MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAEVEKVTEKPEEEESPAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVRMLRKDKEEAEAIKHAKALEEEKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGAATGKPPAPPQPGGPAPGRNASARRRSSTSSSSSSASRTSSSRSRSSSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPARRGGYGPRRRSRSRSRSGDRYRRGGRGPRHHSSSRSSWSLSPSRSRSLTRSRSPSLSRSRSLSRSRSQSHSPSPPREKLSRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWERQYSRQSRSPSPRYSREYSSSRRRSRSRSRSPHYRH
What is the function of this protein?
Probably functions as an alternative splicing regulator.  May regulate the mRNA splicing of genes such as CLK1.  May act by regulating members of the CLK kinase family (By similarity).
What are the official names of this protein?
CLK4-associating serine/arginine rich protein, Splicing factor, arginine/serine-rich 16.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.