PharMolix/UniProtQA huggingface dataset:
Protein: THIE_THEVB
Sequence: MQNLAPASEGQRLRRILDANLDRAREGLRVIEEWCRFGREDAALSAECKDLRQTLGRYHTEELRAARQTDQDPGTALSHPQERDRPTLNAVLTANFARVQEALRVIEEYGKLTDTELSETAKALRYRVYILEQALTLNPLQARLRQLQGAKLYLVTAPSDRLLEIVEAALKGGLPLVQYRDKTSDDHTRLTTARQLQALCQRYGALFLVNDRVDIALGANADGVHLGQMDIPMELARQILGRDRLVGRSTTNAQELERAIAEGADYVGVGPIFATPTKPGKAAVGFDYLQYARKHAPMPQFAIGGIDLSNIEEVIKAGATQVAVVRAIMAAADPEATTRELLRRLSQGEPS
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: BIOF_ECOLC
Sequence: MSWQDKINAALDARRAADALRRRYPVAQGAGRWLVADDRQYLNFSSNDYLGLSHHPQIIRAWKQSAEQFGVGSGGSGHVSGYSVAHQALEEELAEWLGYSRALLFISGFAANQAVIAAMMAKEDRIVADRLSHASLLEAASLSPSQLRRFVHNDVTHLARLLASPCPGQQMVVTEGVFSMDGDSAPLAEIQQVTQQHNGWLMVDDAHGTGVIGEQGRGSCWLQKVKPELLVVTFGKGFGVSGAAVLCSSTVADYLLQFARHLIYSTSMPPAQAQALRASLAVIRSDEGDARREKLAALITRFRAGVQDLPFTLADSCSAIQPLIVGDNSRALQLAEKLRQQGCWVTAIRPPTVPAGTARLRLTLTAAHEMQDIDRLLEVLHGNG
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: RSMB_YERE8
Sequence: MKNTYNLRSIAAKAISQVLDQGQSLSTVLPGLQKSISDKDRALLQELCFGTLRVLPQLEWCIQQLMARPMTGKQRVFHYLIMVGLYQLIYTRIPPHAALAETVEGATALKRPQLKGLINGVLRQFQRQQVELLERAANNDSHYLHPSWLLARIKLAYPDQWQQILDANNQKPPMWLRVNRLHHSRIEYLELLKQANIEALPHDFYPDAVRLITPCAVSDLPGFELGWVTVQDASAQGCVDLLDPQDGEQILDLCAAPGGKTTHILEAAPKVHVLAVDIDEQRLSRVKENLQRLRLHADVRVGDGRTPDEWCGDQQFDRILLDAPCSATGVIRRHPDIKWLRRDSDIAELAQLQSEIIEAIWPKLKKGGVMVYATCSILPEENQQQIATFLQRHSEADLVETGTVSALGRQNLPHPEDGDGFYYAKLIKR
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METXS_BURP6
Sequence: MESIGVVAPHTMHFAEPLRLQSGSVLGNYQLVVETYGELNAARSNAVLVCHALNASHHVAGVYADDPRSTGWWDNMVGPGKPLDTNRFFVIGVNNLGSCFGSTGPMSIDPATGTPYGARFPVVTVEDWVHAQARVADAFGIERFAAVMGGSLGGMQALAWSLLYPERVAHCIDIASTPKLSAQNIAFNEVARSAILSDPDFHGGDYYAHGVKPRRGLRVARMIGHITYLSDDDMAEKFGRALRRADGALDAYNFNFDVEFEVESYLRYQGDKFADYFDANTYLLITRALDYFDPAKAFNGDLSAALAHTKAKYLIASFMTDWRFAPARSREIVKALLDNRRSVSYAEIDAPHGHDAFLLDDARYHNLVRAYYERIAEEVGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTRAB_XENLA
Sequence: MFSLKQPKPSFKSYLLPLQQEDKLNPETKIKKLKPVLLPGEIVVNEVNFVRKCIASDTSQYDLWGKLVCTNFKISFITENSVPFQRFHYKNLLLGEHDVPLTCIEQIVVVNDTKRKQKILSHNQKLKFNPTELIIYCKDFRILRFRFDEAGPESAKKVCLALAHYSQPTDLQLLFAFEYVAQMYHKLDKVNGIDPGGGGDFCQRTPLFESYSDWDREIKRTGASDWRVCSVNEGYMISTCLPEYFVVPSSLADQDLKQYSHAFVGRRMPLWCWNHSNGSALVRMASIKDLLQQRKIDQRVCSGITRSHPLRSEVYKCDLDDNVPSIQDIQAAFSKLRQLCVNEPFDETEEKWLSSLENTRWLEFVRMFLKQAAELVYMLDFSRRSVVLQEEEGRDLSCVVASLVQLMLDPYFRTIIGFQSLIQKEWVMSAYPFLDRCNHLKRSDKESPLFVLFLDCVWQLLQQYPAAFQFTETYLTVVHDSSRISLFGTFMFNSPHQRVQQSTEFAIGKNIQLGEEKGLKFPSVWDWSLQFSAKDRALFNNPLYIGKSVPCVQNGAVKSFKRTKKNYSSTMRGMPPSVKNGMSIQQEIMPRRNSLILKLKPEILQQVPVIPGNGFEQYFRDWFSKPADLHGVILPCLHGTHIQIWKLCYLRWTPEAQINHGGFITAFHKISLLASEIEVLQSRLRQYRAYPMATVTSPVGEQNQMFFRPDELHSSNGSLDILSSSFPFSPIGNLCRRSILGTPLSKFLNGAKIWLSTETLANED
What are the official names of this protein?
Myotubularin-related protein 10-B, Inactive phosphatidylinositol 3-phosphatase 10-B.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Protein: MIAA_THEYD
Sequence: MKRKIVILLGPTGVGKTELSIKIAKLLNAEIISSDSMQIYKYMDIGTAKPTLEQRKEVIHHMIDIVNPWDYFSTGAYIEIVKEVIEKIFEREKIPLVVGGTGLYLRAMTEGIFEGPDADWNLRMELMNKERDNPGFLYNLLKEIDPIKADKIYPSDLRRILRALEVFFKEKKQISELQEKLTKPLSYNFIKIGVTRERKELYRIIEERVDKMICSGLIEEVRNVLTLIKRNATSLSPLPALQAIGYKEIAGCLADLYSIDEAVRLIKKRTKMYAKRQFTWFRKEKDIMWFDISGRHDFEIIAEQIYSALSEILHK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: Y3171_BRUMB
Sequence: MDDKVETGNIDVRLLELLVCPLTKGPLEYDAERSELVSRKARLAYPVRGGIPIMLPSEARSLTE
What are the official names of this protein?
UPF0434 protein BMEA_B0871.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: LSPA_XANOM
Sequence: MSQRPNPSALIWLLLSALVIGLDQWSKAWVLSSLPEYTSVPVIDGFWNWYRTYNTGAAFSFLSDAGGWQLWFFTALAMGISGLLAFWLSRTARGHWRSALPYALVIGGAIGNVIDRLMHGHVVDFIQWYIGSHTWPSFNIADSAIVGGAIGIAVFGLFDKAGKQAS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAH55_RANDH
Sequence: GLLASLGKVLGGYLAEKLKPK
What is the function of this protein?
Has no antimicrobial activity.  Strongly inhibits the formation of NO by neuronal nitric oxide synthase at micromolar concentrations.
What are the official names of this protein?
Dahlein-5.5.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMB_ACTSZ
Sequence: MTELKKTFADQKRKTVETAEFTEDGRYKRKIRSFVLRTGRLSEYQRQMMNDNWSNYGLDYQTEPFDFPAIYGNHNPVILEIGFGMGKSLVEMAQQNPDKNYLGIEVHTPGVGACLAYALEKGIKNLRVICHDATEILRDCIADRSLGGLQLFFPDPWHKAKHHKRRIVQPQFVKTVTQKLTSGGFIHFATDWQNYAEHMLNVLQSVQSAVGIRNISETGDFIPRPDFRPLTKFEQRGQKLGHGIWDLYFIKN
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: NU3M_PHOSU
Sequence: MNLMLTLITNISLSLVLITVAFWLPQLNVYTEKASPYECGFDPMSSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAMQSTNLTMTLTFSFLFLTILALGLAYEWKQKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PTH_ENTFA
Sequence: MKVIVGLGNPGSKYKETKHNIGFITLDEIAYRQNVSFNNSNFEADIAEFFIGTEKVLLVKPLTFMNESGRSVGPLLTYFGVDEEDLIVIYDDLDLEIGKIRLRQKGSAGGHNGIKSLIAHLGTNVFPRIKIGIGRPSKNDTVIHHVLSTFPKETHEEMLLAVKKAADAALYACEGHTFVETMNQFNGK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOBA_YERPP
Sequence: MQPNITGVILAGGRSSRMGGNDKGLIPLNGKPLFQYVIDRFKPQVSDLVINANRNQGLYKESGIPVIDDIITGFVGPLAGMHAGLSYASTEWVVFAPCDVPALPSDLVSQLWQGKKQALAAYANDDERAHPTFALMHISLKTQLADYLIRGDRKLMLFLDSINAQRVKFSGKADLFSNLNTPADCDLWEQKRRGQ
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRXH7_ARATH
Sequence: MGSNVSSVHDVHSSMEITSNGFVVEIESRRQWKSLFDSMKGSNKLLVIDFTAVWCGPCKAMEPRVREIASKYSEAVFARVDVDRLMDVAGTYRAITLPAFVFVKRGEEIDRVVGAKPDELVKKIEQHRV
What is the function of this protein?
Probable thiol-disulfide oxidoreductase that may be involved in the redox regulation of a number of cytosolic enzymes.
What are the official names of this protein?
Thioredoxin H7, AtTrxh7.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant H-type subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPE32_UPEIN
Sequence: GVLDAFRKIATVVKNLV
What are the official names of this protein?
Uperin-3.2.
What are the subcellular locations of this protein?
Secreted.
Protein: VLP18_BORHE
Sequence: MRKRISAIINKLNISIMMMIVVLMIGCGQQAVEAGKDGARAATGGRSLSEVLMEVGKSAENAFYSFMALVSDTLGLRVTKDTKKNEVGGYFNSLGGKLGKASDELEEVAKKSEVEGAKDGPIAVAIRAAVDTAKTTLSTLKGHLESLKGIGDDKVVGWAENDQQGIKPADDGLNKFLNALQSIVKAATDAGVLAPKAGNTTLTVNGVDNKDGAKVLAIDKPGAAVGEKASLIVSAVSGEEILASIVASKEGDQALGAAADGTTTAMSFAKGGTKDNLSNANTPKAAAVAGGIALRSLVKDGKLASHNDNSEKAVQAAGVIAANKLLVSVEDLIKKTVKNVLEKAKEKIDKARAPKATGQQ
What is the function of this protein?
The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time.  Switching between these genes is a mechanism of host immune response evasion.
What are the official names of this protein?
Variable large protein 18.
What is the protein family that this protein belongs to?
Belongs to the variable large protein (Vlp) family. Alpha subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RISBB_PHOLE
Sequence: MNIIEGAITAPHANVAIIVSRFNSFINDSLLSGALDALQRQGLVKESNITVVRCPGAYELPLLAQQLAKKGSYDAIIALGSVIRGGTPHFEYVAGECNKGLAQIALEHQIPVAFGVLTVDSIEQAIERAGTKMGNKGAEAALSALEMINVLAEIEP
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: CYB_AMBTI
Sequence: FGSLLGLCLITQILTGLFLAMHYTADTSSAFSSVAHICRDVNYGWLMRNIHANGASFFFICIFLHIGRGMYYGSYMFKETWNIGVILLFLVMATAFVGYVLP
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TUS_ECO81
Sequence: MARYDLVDRLNTTFRQMEQELAAFAAELEQHKLLVARVFSLPEVKKEDEHNPLNRIEVKQHLGNDAQSLALRHFRHLFIQQQSENRSSKAAVRLPGVLCYQVDNFSQAALVSHIQHINKLKTTFEHIVTVESELPSAARFEWVHRHLPGLITLNAYRTLTVLHAPATLRFGWANKHIIKNLHRDEVLAQLEKSLKSPRSVAPWTREEWQRKLEREYQDIAALPQNAKLKIKRPVKVQPIARVWYKGDQKQVQHACPTPLIALINRDNGAGVPDVGELLNYDADNVQHRYKPQAQPLRLIIPRLHLYVAD
What is the function of this protein?
Trans-acting protein required for termination of DNA replication.  Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks.  The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
What are the official names of this protein?
DNA replication terminus site-binding protein, Ter-binding protein.
What is the protein family that this protein belongs to?
Belongs to the Tus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_CHLSY
Sequence: MKRERINPETLELEERVVQINRVSKVVKGGRRFSFSTVVVVGDGKGHVGIGMGKAAEVPDAIRKGAEAAKRNLIRVPLVHATVPHEVVTKFAATKVMLRPAAPGTGVIAGRGVRPVVEAAGIKDLLSKVYGSNNPVNVVKATFKALSEMTSLHEMASRRDMTPQELMERRTRRETEAA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: YFGH_ECO57
Sequence: MMKFKKCLLPVAMLASFTLAGCQSNADDHAADVYQTDQLNTKQETKTVNIISILPAKVAVDNSQNKRNAQAFGALIGAVAGGVIGHNVGSGSNSGTTAGAVGGGAVGAAAGSMVNDKTLVEGVSLTYKEGTKVYTSTQVGKECQFTTGLAVVITTTYNETRIQPNTKCPEKS
What are the official names of this protein?
Uncharacterized lipoprotein YfgH.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ASPD1_BORPA
Sequence: MNTPLRVGIVGCGVLANAMAGHLARQPRPVEIVGCLVRDPGRARGALPCHGSWEALLAQRPEVVVECAGQAALAQYAQAILAAGVDLVPASVGALADDALRGALLEAAAAAGARIRIPSGAMVGIDGLAAARHVGVAEVLYRGTMPPVALQRYVSGPLPERGLAFAGSAREAVARFPKNANLTGTIALAGIGFDRTRVEMLIDPDATANVHELLARGEFGDFHARVSGLRISESSPSSRIVAGSLAQAALGSGFLALS
What is the function of this protein?
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
What are the official names of this protein?
L-aspartate dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the L-aspartate dehydrogenase family.
Protein: MDTI_SALAR
Sequence: MQQFEWVHGAWLALAIILEIAANVLLKFSDGFRRKCYGILSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWVLFGQRLNPKGWVGVVLLLVGMIMIKLA
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtI.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FPG_LIGS1
Sequence: MPELPEVETVRRGLEKLVLNKKIKDIRVLYSKTIVNEESEFIEKLTNKTIKKIDRRGKYLLFRFSSDLTMISHLRMEGKYFVEPSTKEVEKHTHVVFDFTDGTSLRYNDVRKFGRMQLVKTGMEIQTAGLAKLGPEPKEKTFIVEDFSKNLKRRKKAIKNALLDQTIVAGLGNIYADEVLWMSKIHPETPANKLTEEEVKVLRDNIIKELALATEAGGTTIRSYTDAFRHSGGFQFSLHAYQRTGDPCERCGTPIQRIVVGQRGTHFCPKCQVVKS
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: PERP_HUMAN
Sequence: MIRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSDHGQTSSLWWKCSQEGGGSGSYEEGCQSLMEYAWGRAAAAMLFCGFIILVICFILSFFALCGPQMLVFLRVIGGLLALAAVFQIISLVIYPVKYTQTFTLHANPAVTYIYNWAYGFGWAATIILIGCAFFFCCLPNYEDDLLGNAKPRYFYTSA
What is the function of this protein?
Plays a role as an effector in the TP53-dependent apoptotic pathway.
What are the official names of this protein?
p53 apoptosis effector related to PMP-22, Keratinocyte-associated protein 1, KCP-1, P53-induced protein PIGPC1, Transmembrane protein THW.
What is the protein family that this protein belongs to?
Belongs to the TMEM47 family.
What are the subcellular locations of this protein?
Cell junction, desmosome. Cell membrane; Multi-pass membrane protein. Note=Associated with desmosomes (By similarity). Colocalizes with KRT14 in the cell membrane (PubMed:31898316).
Protein: PURA_JANSC
Sequence: MANVVVVGAQWGDEGKGKIVDWLSERADVIARFQGGHNAGHTLVIDGEVFKLHALPSGVVRGGKLSVIGNGVVLDPWHLVKEIATIRDQGVDISPETLMIAENTPLILPIHGELDRAREEAASSGTKIGTTGRGIGPAYEDKVGRRSVRVADLADRATLEAHVDRALQHHDPLRRGLGIDPIDRNALIDALTEIAPQILQYAAPVWKVLNEKRKAGKRILFEGAQGALLDIDFGTYPFVTSSNVIAGQAATGVGLGPNAIDYTLGIVKAYTTRVGEGPFPTELEDADGQRLGERGHEFGTTTGRKRRCGWFDAALVRQTCATSGVTGISLTKLDVLDGFETLKICVGYDLDGTRLDYLPTAADQQARCTPIYEEMPGWSDSTEGARSWADLPAAAIKYVRRVEELIQCPVALLSTSPEREDTILVTDPFAD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_VIBVU
Sequence: MNNARPIRRALISVSDKTGIVEFAQALAERGVDILSTGGTARLLAEQGIAVTEVSDYTGFPEMMDGRVKTLHPKVHGGVLGRRGQDDEVMAKHGINPIDMVVVNLYPFAETVAKEGCTLADAVENIDIGGPTMVRSAAKNHKDVTIVVNASDYHRVITEMDANDTSLTLETRFDLAIAAFEHTAAYDGMIANYFGTMVPSYGENKEGDEESKFPRTFNQQFIKKQDMRYGENSHQAAAFYVEANPQEASVATARQIQGKALSYNNIADTDAALECVKEFNEPACVIVKHANPCGVALGKDILEAYNRAYQTDPTSAFGGIIAFNQELDAETATAIVERQFVEVIIAPSVSAEAMEVVAAKKNVRLLECGEWTTKTTGFDVKRVNGGLLVQDRDQGMVSLDDLKVVSKRQPTEEELKDALFCWKVAKYVKSNAIVYSKGDMTIGVGAGQMSRVYSAKIAGIKAADEGLQVEGCVMASDAFFPFRDGIDAAAEAGIKCVIQPGGSMRDDEVIAAADEHGMAMIFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: SODM_STRPN
Sequence: MAIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALEKHPEIGEDLEALLADVESIPADIRQALINNGGGHLNHALFWELMTPEKTAPSAELAAAIDATFGSFEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPILGLDVWEHAYYVKYRNVRPDYIKAFFSVINWNKVDELYAAAK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.  May play a critical role against oxidative stress, affecting both the survival and the virulence of S. pneumoniae.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: RLMN_STAAT
Sequence: MITAEKKKKNKFLPNFDKQSIYSLRFDEMQNWLVEQGQQKFRAKQIFEWLYQKRVDSIDEMTNLSKDLRQLLKDNFTVTTLTTVVKQESKDGTIKFLFELQDGYTIETVLMRHDYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVSQVLTVQKALDATEERVSQIVIMGIGEPFENYDEMMDFLRIVNDDNSLNIGARHITVSTSGIIPRIYDFADEDIQINFAVSLHAAKDEVRSRLMPINRAYNVEKLIEAIQYYQEKTNRRVTFEYGLFGGVNDQLEHARELAHLIKGLNCHVNLIPVNHVPERNYVKTAKNDIFKFEKELKRLGINATIRREQGSDIDAACGQLRAKERQVETR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  Confers resistance to some classes of antibiotics.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_CAMLR
Sequence: MSRTTPLKRVRNIGIAAHIDAGKTTTSERILFFTGMSHKIGEVHDGAATMDWMEQEKERGITITSAATTCFWKNHQINLIDTPGHVDFTIEVERSMRVLDGAVAVFCSVGGVQPQSETVWRQANKYGVPRIVFVNKMDRIGANFFNVEEQIKNRLKGNPVPLQIPIGAEDNFKGVIDLITMKALVWEDESKPTDYVEKEIPAELKEKAEEYRVKMIEAVSETSDELMEKYLGGEELTQDEIKAGIKAGCLSLSMVPMLCGTAFKNKGVQPLLDAVVAYLPAPDEVANIKGEYEDGTEVSVKSTDDGEFAALAFKIMTDPFVGQLTFVRVYRGSLESGSYAYNSTKDKKERIGRLLKMHSNKREEIKTLYAGEIGAVVGLKDTLTGDTLASEKDKVILERMDFPDPVISVAVEPKTKADQEKMSIALNKLAQEDPSFRVSTDEESGQTIISGMGELHLEIIVDRMLREFKVEAEVGQPQVAYRETIRKTVEQEYKYAKQSGGRGQYGHVFLRLEPLEPGSGYEFVNDIKGGVIPKEYIPAVDKGVQEALQNGVLAGYPVEDVKVTVYDGSYHEVDSSEMAFKLAASMGFKEGARKAGAVILEPMMKVEVETPEEYMGDVIGDLNKRRGQVNSMDERGGNKIITAFCPLAEMFGYSTDLRSQTQGRATYSMEFDHYDEVPKNVSEEIIKKRNG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUSP_VACCC
Sequence: MDKKSLYKYLLLRSTGDMHKAKSPTIMTRVTNNVYLGNYKNAMDAPSSEVKFKYVLNLTMDKYTLPNSNINIIHIPLVDDTTTDISKYFDDVTAFLSKCDQRNEPVLVHCAAGVNRSGAMILAYLMSKNKESSPMLYFLYVYHSMRDLRGAFVENPSFKRQIIEKYVIDKN
What is the function of this protein?
Serine/tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses.  Dephosphorylates the OPG144 protein.
What are the official names of this protein?
Dual specificity protein phosphatase OPG106, Late protein H1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Approximately 200 molecules of H1 are packaged within the virion and are essential for the viability of the virus.
Protein: YQGF_XANCP
Sequence: MPEAGAIRPDATVLGFDVGSRRIGVAVGTALGAGARAVAVINVHANGPDWVALDRVHKEWRPAGLVVGDPLTLDDKDQPARKRAHAFARELRERYALPVVLIDERSSSVEAAQRFARERADGRKRRRDADTLDAMAAAVIVERWLSAPEQATLLP
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.