PharMolix/UniProtQA huggingface dataset:
Protein: NPL4_ASHGO
Sequence: MILRFRSKHGMQRVNCEGSEQFGTVLDRWVKLVHERAPREAMEVGVAERQIETRIAAEMAQKTVEQLGLKHGDMLSVSFKETGGSLAVAAAPERSSELAVDRELAREEGLIRRSHSRLCRHGDRGMCEYCSPLPPWDRGYQQEQNLKHISFHAHVKELNEHTNKKASGSTYIPPLSPPDFHVNKHCPAPHEPWPRGICSKCQPSAISLQQQEFRMVDHVEFQHSELVNEFINTWRSTGMQRFGYLYGRYARYDNTPLGIKAVVEAIWEPEQHDEQDGLTMDTVAVRVSVAAVDAIAADMGLMRLGMIFTDLTDSGSGDGSVFCKRHKDSFFLSSLEVITAARHQLHHRNACRFSDQGFYSSKFVTCVVSGNLQGEIDVAAYQVSTDAEALVDADIISGSTHPSMAYINEPSAERYVPEIFYMRRNEYGITIKENAKPAFPVDYLIVSLTHGFPVAADTPPTFQAHTGFPWANRQAMGQSQDYLELRRVLLPSIAAGDYTELHRRLSSFHLLLYLHSLQILDASEWRRLVTVATTPAPRGVEAVYDLISGPGWQTLVMILQEAA
What is the function of this protein?
Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus.  Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).
What are the official names of this protein?
Nuclear protein localization protein 4.
What is the protein family that this protein belongs to?
Belongs to the NPL4 family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes mainly at the nuclear periphery and the endoplasmic reticulum membrane.
Protein: METL2_XENTR
Sequence: MEGKRPQFGNRHLDDPSRVFQHNAWDNVQWSEEQESAAHKKVQENSVQPLPLEKQEEYENKASNFWDDFYTIHENRFFKDRHWLFTEFPELSSRSSTQTGTESQEGQVMQLNGCQEETERADVENPFPGASATYRIMEVGCGVGNTVFPILQNNTDPGLFVYCCDFSSTAVELVKSNELYSPSRCFAFVHDVSDEQSSFPMPEHSLDVIVLIFVLSAINPAKMQNVISRLSSLLKPGGCILLRDYGRYDMAQLRFKKGRCLAENFYVRGDGTRVYFFTQDDLDTLFISAGLQKVQNTVDRRLQVNRGKQLTMYRVWIQCKYVKPQETELQNGGCSSE
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).  N(3)-methylcytidine methylation by mettl2 requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite.
What are the official names of this protein?
tRNA N(3)-methylcytidine methyltransferase METTL2, Methyltransferase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHEA_MYCSJ
Sequence: MPRIAYLGPQGTFTESALLQMISGAMVPGGDADDTAVTPVPTDSTPAGLEAVRSGAADYACVPIENSIEGSVLPTLDSLAVGAPLQIFAELTLAVSFSIVVRPDHDGDVATVAAFPVAAAQVRRWLAEHLPAAQLVPAHSNAAAAADVAGGRADAGISTALAAERYGLRSLAAGVVDEPNARTRFVLVGRPAPPPARTGADRTSVALRLPNTPGALVAAMTELSIRDIDLTRIESRPTRTELGTYVFFLDCVGHLEDDAVAEALKALHRRCEDVRYLGSWPTGTAAGAPPPSSDEATRWLTRLREGLPTPPEGGR
What are the official names of this protein?
Prephenate dehydratase, PDT.
Protein: HBB2_RAT
Sequence: MVHLTDAEKATVSGLWGKVNADNVGAEALGRLLVVYPWTQRYFSKFGDLSSASAIMGNPQVKAHGKKVINAFNDGLKHLDNLKGTFAHLSELHCDKLHVDPENFRLLGNMIVIVLGHHLGKEFTPCAQAAFQKVVAGVASALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-2, Beta-2-globin, Hemoglobin beta chain, minor-form, Hemoglobin beta-2 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RL1_BEUC1
Sequence: MTAQSKNYRKAASAIDRDRLYAPLEAVRLAKAGASTKFDSTVEVAFRLGVDPRKADQMVRGTVNLPHGTGKTARVLVFAVGERAEQARAAGADEVGGDELIEKVAGGYVDFDAAVATPDLMGKVGRLGRVLGPRGLMPNPRTGTVTMDVAKAVEEIKGGKIDFRVDKHANLHVVVGKASFDETALVENYASVLDEVLRLKPSSSKGRYIVKATLSTTMGPGIPLDASKTRNLTGEDAA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: TRA1_CAEEL
Sequence: MMAPSTEDPDTVVEAQRRGSFSKKKNANGWNKVELVDQCAKQMGSEDKQPGGGDVKTENDPSKNGLGSATSNFIQSSVPPSHQTLSNPLQLSPPAEASVAQQSGASQVFPTFQAALGASSDELLQPNATSSSTSSSASTSSIVPVVKFTNQTAPNGSTVATSVGQNVRLTINGKRVGRPPGTFKRPQNNAANSSNSGNDSDMMGDHDLTCRWKSCNSSFQTLKALVDHVQESHVQSTEQEHHAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHTGEKPYKCEFADCEKAFSNASDRAKHQNRTHSNLKPYSCQIPQCTKSYTDPSSLRKHIKAVHGDDEYEKAKKSRPANYSNRRRPDHRLAPPTGAMSHPYLATPNSGASVVAHSSVHQQNFINMALAQHHHNAQRAQQLMAATGNVMPMMDPASAAAAAQAQAHHQAQAQMLQTHMMQQAQIQAAAQMQAQVQHQAAMQAHAMQQAQMVLQNNLLGAQSLLSPFSPLLPPSRAPNVMAMLQTPPTPTSVAPMFDIMTSRAPMAPVVSAPTAPAPLVPAPVPASPVFDELREQMREVEPLQQQQQQEPMDQDLQDIRVDGDSDDEDEEEPRTPSGALLLPRGGNNGDGGFGGSGSSRASSGSGTMELSAAPISQNGSRASGSGERGMRSFLIADILQLAADFQNERLLSDVLDLAIFDTRDVRSLHNIYQVYIRAHKAIPITRRPLDWNETHQLHNLYHDPRFNRAEHQDSPAIRDRDTRFWRTIAEANTMRQRQIEPVPLDDDDEGYFDEMVHRVQNGRLNEQFMEGFESDDDDGFEDEDDVPGLGIAVYRGRRRVRREALKQANLDIQEAETAGRNVGGFGDEEDRNNRGHDQDRSFLDHYYPPMVVVVETESPQIVRDQEMMRQFEEAKKNVETDEIKKRAEAMQFGTSSSHHHTKTLLIQRALFDKTSSVRRSLLQFITISVDQEELRQSCHATSAPQGAHVVHNVVDEFDSIMRAQEDSNNRILLSLDIPAPSAVTGVSGSITHADNSALQLQQEQPTSSFSSWFPEDDPIYALPPPPPPPAPPRRRRSADNKDDSENIPKKPRHQF
What is the function of this protein?
Plays a major role in controlling sexual phenotype (PubMed:1339311).  Terminal global regulator in a well-characterized cascade of sex-determining genes (PubMed:8367286).  Promotes female development (PubMed:11124807).  Interacts with tra-2 to promote spermatogenesis (PubMed:11250902).  Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity).  Association with chromatin and at the fog-3 promoter requires wdr-5. 1, and may also require wdr-5. 2 (PubMed:24682813).  With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By similarity).  In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons (PubMed:18056428).  Represses the expression of the transcription factor dmd-3 in hermaphrodites to govern the timing and extent of male tail tip morphogenesis (PubMed:18550714).  Plays a role in controlling the sex-specific differentiation of PHC sensory neurons and represses the development of male-specific morphological features (PubMed:28065609).
What are the official names of this protein?
Sex-determining transformer protein 1, Hermaphrodization of XO animals protein 2.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localization with chromatin in the nucleus in part depends on normal function of wdr-5.1.
Protein: URE3_CUPPJ
Sequence: MELTPREKDKLLIFTAALLAERRRARGLKLNYPEAVALITAAIMEGARDGRTVAELMHEGTTVLSRDDVMDGVAEMIPEIQVEATFPDGTKLVTVHHPIV
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_PSYCK
Sequence: MARFYRRRKFCRFTAEGITHIDYKDVELLKQYISDNGKIVPSRITGTSTKYQRQLATAIKQARYLSLLPYTDNHQG
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: ILVD_RHIME
Sequence: MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLHGKTHALDLVDAMVAAADDKVSDEDVQIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIVDLARRYYEQEDERVLPRNIATKQAFENAMALDIAMGGSTNTVLHILAAAYEGEIDFTMDDIDRLSRKVPCLSKVAPAKADVHMEDVHRAGGIMSILGELDKGGLINRDCPTVHAETLGDAIDRWDITRTSSDTVRKFFRAAPGGIPTQVAFSQEARWDELDTDRENGVIRSVEHPFSKDGGLAVLKGNIALDGCIVKTAGVDESILKFSGPARVFESQDAAVKGILANEIKAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAANGGTIGLVREGDMIDIDIPNRTISLRVDEAELAARRTEQDAKGWKPVEQRKRRVTTALKAYAAFATSADRGAVRDLGDR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: AQP1_MILTA
Sequence: MQKMSEKPLYRAAENPTRNADRRAGRFEEEELISKTGRHPDMVIQFQDDADDQHTSHYEGNWRHYFHKKLHIKNRLIRDWLSESLAMFLFMSLLLGGAATAHFTGKQDDPMLTAVFHGFSAVFGIYVGAGVSGGIINPALTFAVALLGRVSWRKCLVLVSAQYFGSFIASAVVYLIYYESLQNYAKTADDNGEFLQKTAGIWSTFPKPYLSMTGAIFNQIFCTMLLSIGFLSISDHKNFRPTKGLFPFAVGLLIMTVFLAFSYSAGAAMNPARDLSPRLWSLIIGYGNEVFSHNDYKWFWIPWLFPYVGALFGAVMYQIFVGVHWPDKQSTKR
What is the function of this protein?
Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis (PubMed:23761966).
What are the official names of this protein?
Aquaporin-1, AQP-1.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MP2K6_DANRE
Sequence: MEGGSDKESKVFCDSPSPNPKGEMSVPSNVRGKKKLPKELKLPKEVFEKPAPAPTPPRDLDSKAYVTIGEKNFVVKADDLEQIGELGRGAYGVVDKMRHVPSGVIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHEKGKTIPEDILGKITVSIVKALEHLHSNLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADRFSADFVDFTSQCLRKNSTERPTYTELMQHPFFTLHDSKDTDVASFVKTILGD
What is the function of this protein?
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses.  The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors.  Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is necessary for blastomere cleavage.
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAPKK 6, Mitogen-activated protein kinase kinase 3, zMKK3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Binds to microtubules.
Protein: ACT_CYAM1
Sequence: MTEEEITALVIDNGSGMVKAGFAGDDAPRAVFPSIVGRPRHQAVMVGMGQKDSYVGDEAQSKRGILSLKYPIEHGIVTNWDDMEKIWYHTFYNELRISPEDHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVVDSGDGVTHTVPIYEGYALPHAIMRIDLAGRDLTDYLAKILTERGYSFTTTAEREIVRDIKEKCCYVAQDYDHELEIASSQPAKIDKQYELPDGQIITIGSERFRCPEVLFQPSLIGMEGEGIHNVAYQSIMKCDVDIRKDLYANVVLSGGTTMFPGIADRMQRELASVAPSSVKIKLVAPAERKYSVWIGGSILASLSTFQQMWISKAEYDEFGPSVVHRKCF
What is the function of this protein?
Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y1494_AQUAE
Sequence: MPFIYRRRVQFYETDAQGIVHHSNYFRYFEEARGEFLRSKGFPYSKMRDMGLEVVLLNAYCEYKKPLFYDDVFEVHLNLEELSRFTFTFSYIVFKEDIAVAKANTKHCMVKNGKIVSIPKEVLEVLKD
What are the official names of this protein?
Putative esterase aq_1494.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.
Protein: S28A3_MOUSE
Sequence: MSRADPGKNSEPSESKMSLELRPTAPSDLGRSNEAFQDEDLERQNTPGNSTVRNRVVQSGEQGHAKQDDRQITIEQEPLGNKEDPEDDSEDEHQKGFLERKYDTICEFCRKHRVVLRSTIWAVLLTGFLALVIAACAINFHRALPLFVITLVTIFFVIWDHLMAKYEQRIDDFLSPGRRLLDRHWFWLKWVVWSSLILAIILWLSLDTAKLGQQNLVSFGGLIMYLILLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGRQVQTFLGYTDTGARFVFGEKYTDHFFAFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFIGQTESPLLVQPYLPHVTKSELHTIMTAGFATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKSAMKMENGDSRNLLEAASQGASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFNYPELSFELICSYIFMPFSFMMGVDWQDSFMVAKLIGYKTFFNEFVAYDHLSKLINLRKAAGPKFVNGVQQYMSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAGTIACFMTACIAGILSDTPVDINCHHVLENGRVLSNTTEVVSCCQNLFNSTVAKGPNDVVPGGNFSLYALKSCCNLLKPPTLNCNWIPNKL
What is the function of this protein?
Sodium-dependent, pyrimidine- and purine-selective (PubMed:11032837).  Involved in the homeostasis of endogenous nucleosides (PubMed:11032837).  Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine) (PubMed:11032837).  Employs a 2:1 sodium/nucleoside ratio (PubMed:11032837).  Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (By similarity).
What are the official names of this protein?
Solute carrier family 28 member 3, Concentrative Na(+)-nucleoside cotransporter 3, CNT 3, mCNT3.
What is the protein family that this protein belongs to?
Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL34_XANOR
Sequence: MATKRTFQPSNLKRARDHGFRARMATADGRKILARRRAKGRKRLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: HTPX_SINMW
Sequence: MNLMRTAMLLAFMTVLFMAVGYVIGGRGGMMIALVIAAGMNFFSYWNSDRMVLRMYRAQEVDERSAPEYYGIVRDLAKNAGLPMPRVYVIDSPQPNAFATGRNPENAAVAASTGLLHSLSYEEVAGVMAHELAHIQYRDTLTMTMTATLAGAISMLGNFAFFFGGNRENNNPLGFIGVLIAMIVAPLAAALVQMAISRTREYSADRRGAEICGNPLWLSSALRKIAGAAHVVHNPDAERNPATAHMFIINPLSGERMDNLFSTHPNTENRVVALERMAREMSTGSTAPVRPDNAVRKSRSVPRTGWGRGGSEPPKGPWS
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROA_STRPM
Sequence: MKLRTNAGPLQGTIQVPGDKSISHRAVILGAVAKGETRVKGLLKGEDVLSTIQAFRNLGVRIEEKDDQLVIEGQGFQGLTAPCQTLNMGNSGTSMRLIAGLLAGQPFSVKMIGDESLSKRPMDRIVYPLKQMGVEISGETDRQFPPLQLQGNRNLQPITYTLPISSAQVKSAILLAALQAKGTTQVVEKEITRNHTEEMIQQFGGRLIVDGKRITLVGPQQLTAQEITVPGDISSAAFWLVAGLIIPGSELLLKNVGVNPTRTGILEVVEKMGAQIVYEDMNKKEQVTSIRVVYSHLKGTIISGGLIPRLIDELPIIALLATQAQGTTCIKDAQELRVKETDRIQVVTDILNSMGANIKATADGMIIKGPTVLYGANTSTYGDHRIGMMTAIAALLVKQGQVHLDKEEAIMTSYPTFFKDLERLCHD
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNBI_SHV21
Sequence: MATKTAQPSADNLGSRAPVEPCGYIYVYPKEGFPFKEASLLGNKNVGASAMSLPLLSDLTVESNFSFNVKAVHKKIDMTTLLVRVSAYHREAIVFFNTDLFEPIFVGPGLDILCSDARSLFGYTNFVPRTDLRDTVDIKDLYAPFYSEDSCFMAVVVTEGFKERLYFGNLVPIIAQGLKVQINGREAVKIPLYDEDLFSKSHEHLPRFYIPSVSKYLHDSVFTSIAQALRIRDVESVIRASEKQSIQDQYKLAKIVNSKDFSLQSVKCQDASAFMVIDCIAAELAMSYGLSFLEAPQDPCAVLDYTSWPIFETAETEEDRIKAIQDWNAMMSVHVYTHLFSTNSVLYLTKINKQTQSNKSEQNVYNTYFMQHGLAYAADATQRENGEPAFSGAPKFSGGTYTLYHLALASSFSPHLLARNCYYMQFCQHQKSTTNANYSVPQYVGTAAASDLCELCQGTCPASCIHTLFYRLKDRFPPVLGSQRRDPYVVTGVSGQYNDLDMLGNFATFREKEDEAVQNAESEKYTYWQLIQNVVEKLSTMGVTEGTVGSELITDIQSFLKTFRDIDNVVDSEVVKFMNCLVKNNINFRETIKTVHHVLHYCCNVFWQAPCAMFLNLFYKSVLAIIQDICLPIAMTYEQDNPSIGMMPSEWLKVHYQTIWTNFKSSCLDRGVLTGSEHKIVHTDMFCDFLNIDSALSGQIVPMKMQVRLAKALLTVPKTIKIKNRIVFSNSSMTETIQSGFIKSATKKDSYIVTGPYMKFLNSLHKVMFPNAKISALYLWHTFSQKKQLPVLPGISRENMVELANYVETSSKMHDDMNVLDIIPTTLLTYAKVRLNNTILRTCGQTQFYATTLQCLLPTLQTISATEYPHVLLDQSIMSVDHYLSSIKDKHALTVQTTLKEDIATVGKQRPIVTVPLVVNKYTGINGNTQIFQCGNLGYFMGRGVDRNLIPDSTGFRRQNNSSYMRRRHVFMTPMVAHLVKKNSNLNNLTFEVETIRKNVQNIFEDKDNLNIFDNVVLELVKGLGDSCENITEDDLQFYLGEYYIMSDEIWSRFQIITDSGAPWSVENVTKVLGCNKQEECKFEFVGVEEQLSCVPPQIEEFAPQATLSTLAASRKRKITSILSDIDL
What is the function of this protein?
Plays several crucial roles in viral infection.  Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein.  May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.  Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle.  Can also catalyze the renaturation of complementary single strands.  Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments.  This process is driven by the protein which can form double-helical filaments in the absence of DNA.
What are the official names of this protein?
Major DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae major DNA-binding protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=In the absence of DNA replication, found in the nuclear framework- associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).
Protein: NANA_RHIME
Sequence: MKLEGIYSALLTPFSEDESIDRQAIGALVDFQVRLGIDGVYVGGSSGEAMLQSLDERADYLSDVAAAASGRLTLIAHVGTIATRDALRLSQHAAKSGYQAISAIPPFYYDFSRPEVMAHYRELADVSALPLIVYNFPARTSGFTLPELVELLSHPNIIGIKHTSSDMFQLERIRHAVPDAIVYNGYDEMCLAGFAMGAQGAIGTTYNFMGDLFVALRDCAAAGRIEEARRLQAMANRVIQVLIKVGVMPGSKALLGIMGLPGGPSRRPFRKVEEADLAALREAVAPVLAWRESTSRKSM
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_BURCM
Sequence: MSDILDRIIAVKREEIAAAMRSAPLEALKLEASARDLRDFVGALRAKQAAGHAAVIAEVKKASPSKGVLREHFVPADIARSYAAHGAACLSVLTDEQFFQGSVRYLEEARAACTLPVLRKDFIVDAYQILEARAMGADAILLIAAALDTPLMQDLEAYAHSLGLAVLVEVHDRDEMEQALTLKTPLLGINNRNLRTFETSIQTTLDMLDMIPPERIVVTESGILSRTDVDTMRAANVNAFLVGEAFMRADQPGEELARMFF
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: SCPB_STRP4
Sequence: MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQKYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQPITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHLEELPVIDELEIQAQESQLFGERIEEDENQ
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: NPP2_YEAST
Sequence: MLLFEQPVDLEKNNEDDTNIKPFAISRHFLLKLLLCGIILIELLLYSKCPKPIDNGPRTIANRSNTYFNGTHDFKTLTILISIDGFHPRLIDAKYTPFLYNLHNLRSPYDMNITTAPYMIPSFPTQTFPNHWSMVTGKYPIEHGIVSNIFWDNFTSSEFRPNNLDARIWSNTADPIWQLLQTESQGEYKVATHMWPGSEVVYEDHGDVPRERMPFYFGKFNQWEKLQDKLAQIFRYIDMPQLKDRPELVISYIPNVDSYGHSFGYDLRDKRLQKLIGEVDGFFLDLIEGLQKRNLLKISNVMIVSDHGMSNVNANDGEHVVVWERVFPADAMSAFISHLYNEGPMMMVCLKNPRDKQWICDLIEAQLEKAYGDEISRKFHVILKEDFDPSWKYFQYDNRKHRYDDRVGDIWILADEYYAIVKEMGDVPIGIMGTHGYNFNNCSDMASIFIGMGPMFNNEVVPPFENIEVYNMLIKASALLGEEKTKKEKSLLQ
What is the function of this protein?
Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and PHO5.
What are the official names of this protein?
Ectonucleotide pyrophosphatase/phosphodiesterase 2, E-NPP 2.
What is the protein family that this protein belongs to?
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RL6_PIG
Sequence: MAGEKAEKPGTKEKKPEAKKADAGGKVKKAKKVKKGKPHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYSAAKSKVEKKKKVRVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSKHVRKLRASITPGTILIILTGRHRGKRVIFLKQLSSGLLLVTGPLSLNRVPLRRTHQKFVIATSTKIDISGVKIPEHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEISEQRKVDQKAVDSQILRRIKAVPQLQGYLRSVFALTNGIYPHKLVF
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:24930395).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24930395).
What are the official names of this protein?
60S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL6 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (PubMed:24930395).
Protein: PSBE_DAUCA
Sequence: MSGSTGERSFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTENRQGIPLITGRFDPLEQLDEFSRSF
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RIMM_FRATW
Sequence: MSQDFVEIAKIGATYKLNGELNLYSLANSIETLLSYGDWYIQLPATNVWQQLKGESVLKRADKVYIKLANINNADTAKKYVNALIGVPKRALPQLAEDEVYFKDLIGCSVKNINNDSFGVVVDIIETGANEVLVCKEDNSEYLIPYVKQYIVSEDLNSKKIVVDWEYDY
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.