PharMolix/UniProtQA huggingface dataset:
Protein: TPF_RANTE
Sequence: FLPLIGKVLSGIL
What is the function of this protein?
Amphipathic alpha-helical antimicrobial peptide with potent activity against Gram-positive bacteria, weak activity against Gram-negative bacteria, and moderate activity against fungi (By similarity).  Also displays anti-leishmania activity by damaging parasite membrane (PubMed:25668079).  Stimulates insulin release from pancreatic beta-cells in a dose-dependent manner, without increasing intracellular calcium (PubMed:29349894).  Protects beta-cells against cytokine-induced apoptosis and augments beta-cells proliferation (PubMed:29349894).  In vivo, intraperitoneal injection together with a glucose load into mice does not have effect on plasma glucose levels (PubMed:29349894).
What are the official names of this protein?
Temporin-1Tf, TF, Temporin-F.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL29_MYCVP
Sequence: MAVGTTTGELRELTDEELTDKLRESKEELFNLRFQMATGQLANNRRLRVVRQEIARLYTVLRERELGLAAGPGGEDS
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: PUR9_ECOBW
Sequence: MQQRRPVRRALLSVSDKAGIVEFAQALSARGVELLSTGGTARLLAEKGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDAIMEEHQIQPIDMVVVNLYPFAQTVAREGCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYDAIIKEMDDNEGSLTLATRFDLAIKAFEHTAAYDSMIANYFGSMVPAYHGESKEAAGRFPRTLNLNFIKKLDMRYGENSHQQAAFYIEENVKEASVATATQVQGKALSYNNIADTDAALECVKEFAEPACVIVKHANPCGVAIGNSILDAYDRAYKTDPTSAFGGIIAFNRELDAETAQAIISRQFVEVIIAPSASEEALKITAAKQNVRVLTCGQWGERVPGLDFKRVNGGLLVQDRDLGMVGAEELRVVTKRQPSEQELRDALFCWKVAKFVKSNAIVYAKNNMTIGIGAGQMSRVYSAKIAGIKAADEGLEVKGSSMASDAFFPFRDGIDAAAAAGVTCVIQPGGSIRDDEVIAAADEHGIAMLFTDMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: PDXH_ROSDO
Sequence: MTERTGKFAGDNPFTIAESWLAEAQESEVNDPNAIALSTVDADGMPNARMVLLKGVEPDAFVFYTNYESAKARELDGAGKAAFVMHWKSLRRQIRVRGHVSREDGDAADAYFASRSLKSRLGAWASKQSRPLSSRAALMAEVAKMTATHGTNPKRPPFWGGFRITPVEIEFWADGDFRLHDRFVWRRETPQSEWHVTRLNP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: Y753_POLAQ
Sequence: MLIVLSPAKSLDYKTPIKVKAPTLPEFASESAKLIAELKKLAPQDVAKLMSLSDQLAVLNVGRYRDWSKKFTVDNSKPAIYAFDGDVYDGFDVKSLNTKAIDFAQDHVRILSGLYGVLRPLDLMQAYRLEMGTSLKNIRGKDLYAFWGGRVTDSLKALLGKQKKPVLLNLASEEYFKVLQPKELDCPVIAPIFQDAKDGKYKIISFYAKRARGLMARYVVENRITDPEDLKGFNLDGYKYFAAESKIDKPVFRRAERK
What are the official names of this protein?
UPF0246 protein Pnuc_0753.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: PLPHP_ECOL6
Sequence: MNDIAHNLAQVRDKISAAATRCGRSPEEITLLAVSKTKPASAIAEAIDAGQRQFGENYVQEGVDKIRHFQELGVTGLEWHFIGPLQSNKSRLVAEHFDWCHTIDRLRIATRLNDQRPAELPPLNVLIQINISDENSKSGIQLAELDELAAAVAELPRLRLRGLMAIPAPESEYVRQFEVARQMAVAFAGLKTRYPHIDTLSLGMSDDMEAAIAAGSTMVRIGTAIFGARDYSKK
What is the function of this protein?
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
What are the official names of this protein?
Pyridoxal phosphate homeostasis protein, PLP homeostasis protein.
What is the protein family that this protein belongs to?
Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
Protein: Y232_STRT2
Sequence: MTSLLITGYKSFELGVFKDKDPKVNIIKKAIKRDLKRFLDEGVDWMIFTGNLGFEFWALEVAKELQKDYPLRLATLFPFKTHGQNWSEANQEKLAAFKQVDFVKYSFPAYQSPAQFKQFNQFLIDNTDQAYLFYEPENETNLKYFYNMIIAASDYPLFRLTFDDLNEVMSE
What are the official names of this protein?
UPF0398 protein stu0232.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: CLCD_PSEKB
Sequence: MLTEGISIQSYDGHTFGALVGSPAKAPAPVIVIAQEIFGVNAFMRETVSWLVDQGYAAVCPDLYARQAPGTALDPQDERQREQAYKLWQAFDMEAGVGDLEAAIRYARHQPYSNGKVGLVGYCLGGALAFLVAAKGYVDRAVGYYGVGLEKQLKKVPEVKHPALFHMGGQDHFVPAPSRQLITEGFGANPLLQVHWYEEAGHSFARTSSSGYVASAAALANERRLDFLAPLQSKKP
What is the function of this protein?
Ring cleavage of cyclic ester dienelactone to produce maleylacetate.
What are the official names of this protein?
Carboxymethylenebutenolidase, Dienelactone hydrolase, DLH.
What is the protein family that this protein belongs to?
Belongs to the dienelactone hydrolase family.
Protein: YJJQ_ECO57
Sequence: MLPGCCKNGIVISKIPVMQAGLKEVMRTHFPEYEIISSASAEDLTLLQLRRSGLVIADLAGESEDPRSVCEHYYSLISQYREIHWVFMVSRSWYSQAVELLMCPTATLLSDVEPIENLVKTVRSGNTHAERISAMLTSPAMTETHDFSYRSVILTLSERKVLRLLGKGWGINQIASLLKKSNKTISAQKNSAMRRLAIHSNAEMYAWINSAQGARELNLPSVYGDAAEWNTAELRREMSHS
What are the official names of this protein?
Uncharacterized protein YjjQ.
Protein: RL7_THEMA
Sequence: MTIDEIIEAIEKLTVSELAELVKKLEDKFGVTAAAPVAVAAAPVAGAAAGAAQEEKTEFDVVLKSFGQNKIQVIKVVREITGLGLKEAKDLVEKAGSPDAVIKSGVSKEEAEEIKKKLEEAGAEVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: DAPEL_BACCQ
Sequence: MVVSKFVQIRRDLHKIPEIGFKEWKTQRYILDYIGTLSNEHVEVKVWRTGVIVKVKGKNPEKVIGYRADIDGLPITEETGYEFASVHEGMMHACGHDLHTTIGLGLLTAAVTERIDDDLVFLFQPAEEGPGGALPMLESEELKEWKPNIILGLHIAPEYPVGTIATKEGLLFANTSELYVDLKGKGGHAAYPHTANDMIVAASHLVTQLQSVISRNVNPLDSAVITIGKITGGTVQNIIAEKSRLEGTIRTLSVESMSRVKSRIEGIVAGIEASFQCEAIIDYGAMYHQVYNHEALTREFMQFVSEQTDMKVITCTEAMTGEDFGYMLQEIPGFMFWLGVNSEYGLHHAKLKPDEEAIEKAIVFLDQYVKWKGTRK
What is the function of this protein?
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
What are the official names of this protein?
N-acetyldiaminopimelate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
Protein: RL15_CAUVN
Sequence: MTKLNELAPREGSTKGRMRVGRGPGSGKGKTAGRGVKGQKARSGVAINGFEGGQMPLHMRMPKRGFNNPFRLEFAEVNLWRLEQAVEAGKIKKGAELDAAALIAAGVIRRELDGVKLLAKGEIKTALKLTVYSATEAAIKAVEAAGGSVTVTKKAKAQAEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: HISZ_BACC3
Sequence: MTKWKRANPNGTRDYLFEECTLIEEVEQKLRRTFLERGYEEIRTPTIEFYDVFAFQSRPIDEEKMYKFFDEKGRIIVLRPDMTIPLARVVGTQRCDTPLKVTYSGNVFRANESLAGKYNEIVQSGIEVIGIDNVRAEIECVISVIQSLQKLKVQSFTIEIGQVQLYKCIVKKLSIHEEEEKVLRTYIESKNYASLSNFIRDKKLDRCDETVKLLEKLPRLFGNLEVIEEAEKLASSNEMKMAITRVKEIYEAIEKLGYGSYISIDLGMIQHLDYYTGVIFKGYIYEIGEEIVSGGRYDELIGNFGEMLPAVGLAVQVNQIVKALQEQQEPYERKRIDIMIHYELNRLAEAERLRNLLQKDGKKVALSLFSNLNDTFQFARKNQIVTVVEAKSESLVEYVWKEKWVVQKEGETSCVTFKLR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_REOVJ
Sequence: MSSTILTQFGPFIESISGIIDQSNDIFEEAAKAFSAFTRSDVYKALDEIPFHDHATVHIPPTIYSKPSHDSYYYVDALNRVRRRTYQGDDDVYVPNCSIVELLEPHETLTSYGRLSSAIEARAKEGDPQARIATTYARISESQARQIKAPLEKFVLALLVAESGDALYDPILQKYDDVADLTHNCPLWCFREICRHVSGPLPDRAPYLYLSAGVFWLMSPRMTSAIPPLLSDLVNLAILQQTAGLDPSLVKMGVQVCLQAAASASYAWYVLKTKSVFPQNTLHSMYETLEGGFCPNLAWLEPRSDYKFMYMGATPLSGKYARTAPSNETRARQLGEKYGLSTIIGDLRQRTRQFTKHDFASVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQKDWTGPIGEIRVLKDTTSSIARYLYRTWYLAAARMASQPRTWDPLFQAIMRSQYVTARGGSGAALRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPFSHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSAPHTLTADYINYHMNLSTTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLSVIMAAIHEGVASSSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMVQHLSKLYKRGFSYRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETFLNVWGPEHTNDPDVLRLMRSLTIQRNYVCQGDDGLMIIDGTTAGKVSSETIQKMLELISAYGEEFGWKYDIAYDGTAEYLKLYFIFGCRIPNLSRHPIVGKERANSSAEEPWPAILDQVMGIFFNGVHDGLQWQRWIRYCSSLCCAFSRQRTMIGEEVRYLQYPMWSFVYWGLPPVKLFGSDPWIFSWYMPTGDLGMYSWISLIRPLMTRWMVANGYVSERCSSIFGNADYRRCFNDIRLYQGYYMARLPRNPKKSGRAAPRETREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHNPPSLFDVPHKWYQGAQEAATATREELSDMDDTLLRSRRHTYSSFSKLLEAYLRVRWRMCEAREPSVDLRLPLCAGIDPLNSDPFLKMVSVGPMLQSTRKYFAQTLFMAKTVSGLDVNAIDSALLRLRTLGADKKALTAQLLMVGLQESEADALAGKIMLQDVNTVQLARVVNLAVPDTWMSLDFDSMFKHHVNLLPKDGRHLNTDIPPRMGWLRAILRFLGAGVAMTATGVAVNVYLEDIDGGGRSLGQRFMTWMRQEGRSA
What is the function of this protein?
RNA-directed RNA polymerase that is involved in transcription and genome replication.  Following infection, it catalyzes the synthesis of fully conservative plus strands.  After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands.
What are the official names of this protein?
RNA-directed RNA polymerase lambda-3, Lambda3, Lambda3(Pol).
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Found in the inner capsid (12 copies).
Protein: GCH1_STRMU
Sequence: MNEKIMSDQKKIEEAVYQLLEALGEDPNREGLLDTPKRVAKMYQEMFAGLNEDPKDQFTAVFSEEHEDVVLVKDIPFYSMCEHHLVPFHGLAHVAYIPSDGCVTGLSKLARAVEVVSKRPQLQERLTVQIANALEEALKPKGVLVMIEAEHMCMTMRGIKKPGSKTVTRVVRGICQSDKETRQEIIAMIHHN
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: BP25_BPT4
Sequence: MANINKLYSDIDPEMKMDWNKDVSRSLGLRSIKNSLLGIITTRKGSRPFDPEFGCDLSDQLFENMTPLTADTVERNIESAVRNYEPRIDKLAVNVIPVYDDYTLIVEIRFSVIDNPDDIEQIKLQLASSNRV
What is the function of this protein?
Baseplate protein that is located next to the tail tube (inner baseplate).  Involved in sheath assembly.  The gp25-(gp6)2-gp7 module is involved in sheath contraction (PubMed:27193680).
What are the official names of this protein?
Baseplate wedge protein gp25, Outer wedge of baseplate protein, Protein Gp25.
What is the protein family that this protein belongs to?
Belongs to the GpW/Gp25 family.
What are the subcellular locations of this protein?
Virion. Note=Present in 6 copies in the baseplate.
Protein: LAM5_YEAST
Sequence: MSDVDNWEPVSDNEDSTDSVKQLGPPFEHASNNDNAGDTEAESLQEVPLNTETNDVRKNLVVITNQSAADEHPTEIKHDQSRTSSTSSFFSGMISSFKSNVPSPVSRSTTPTSPVSQPSIISHRREPSMGSKRRSSRRISNATIAEIGSPLQQVEKPDEVKTRLTPSQMKEDNYDHRRFVEERYMDTPYHYASEQRNKDFHETFKSVPKDDRLLDDFNCGLNRELLYQGKLYITETHLCFNSNVLGWIAKVLIAFEDVTFMEKTSAAGLFPSAISIETKMGKTLFNGFISRDAAFGLMKEVWSRTLLQKDMASENINTKAEKSGNGKEIDDAINSIDEENNDKDANDNDTNENDDENISTNETTPNSTSSSPDKEKEKAYKLRADSSYQYDGPIYHHSTSFPAEPMANNEFVLKELPFDCAPGILFEIMFNSEQNEFLLDFLRGQEGSQITTIPNFTSIDGSSMTLKREYSYEKALHFPAGPKSTTCYVAEVIKRKDPDTYYEVISSIRTPNVPSGGSFSTKTRYLIRWNDEITCLLRVSFWVEWTGSSWIKGMVENGCKNGQLEAAQLMERILSKFIKNNVEECQITISKEEEEQDDKEVKNKLKEVDLEQPREAVVTAPAIAEQQGLKVTMETWLFLYLIVVVLLLFNLFYIRSIAVSLHQLVKLQLVELKL
What is the function of this protein?
May be involved in sterol transfer between intracellular membranes.
What are the official names of this protein?
Membrane-anchored lipid-binding protein LAM5, Lipid transfer at contact site protein 2, Lipid transfer protein anchored at membrane contact sites 1.
What is the protein family that this protein belongs to?
Belongs to the YSP2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Localizes to intracellular puncta representing endoplasmic reticulum (ER)-mitochondrion membrane contact sites, nucleus-vacuole junctions (NVJ) and other non-NVJ ER-vacuole contact sites.
Protein: FABZ_METRJ
Sequence: MSEAARETGTELGTADIQTLLELLPHRYPFLMVDRIVEIDRDESCVGIKNVTANEPQFMGHFPDMPVFPGVLLIEGMAQTAGAICCRHIRADGRNTKQVFFMTIDKCKFRKPVTPGDQVRFHMTKLNQRRTMWWFRGEARVDGTLVAEAEISAMLVTE
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_BACCZ
Sequence: MKTVTEFQNKNILVLGIAKSGYAAATLLQKLGANVIVNDGKPLAENVLAAELQAKGMDVVCGGHPLELLERNISLVVKNPGIPYSNPILVAAKEKQIPIVTEVELAYRISEAPFVGITGSNGKTTTTMLTFEMLKEGQKHPVIAGNIGTVACEVAQDAKENEVVVTELSSFQLMGVELFQPKIAAFLNLFEAHLDYHGTKKEYGLAKANIFKNQTENDYSVINADDADVMALSAYSKGQKVLFSTTKEIEDGACIKDNALYFKAEKVVEVDDIVLPGQHNLENILAAMSIAKLLGVSNEAITAVLKRFTGVKHRLEYVTTINNRKFYNDSKATNMLATEKALSAFTQPTVLLAGGLDRGNEFDDLIPYFKNVKAIVTFGQTAPKLVRAAEKAGLDTIESVDTLDEAVVKAYAHSTDGDVILLSPACASWDQFKTFEERGDIFIQAVHKLI
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IST1_YEAST
Sequence: MAPSMIPFTIKLKTCLKMCIQRLRYAQEKQQAIAKQSRRQVAQLLLTNKEQKAHYRVETLIHDDIHIELLEILELYCELLLARVQVINDISTEEQLVKEHMDDGINEAIRSLIYAILFVDEVKELSQLKDLMAWKINVEFVNGVIADHIDVPEKIIKKCSPSVPKEELVDLYLKEIAKTYDVPYSKLENSLSSSSSNISSDFSDPSGDIEDNDEEKPILALDNDDNDNADAKHPITVKKPRQNSENIKNELKIPKDIKKEVIEKKQSEKKTTKRKTKKEQENDELDELKKRFDALRRK
What is the function of this protein?
Involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.  The lumenal sequestrated membrane proteins are targeted into the vacuole after fusion of the endosome with the vacuole.  Regulates the recruitment of VPS4 to the ESCRT-III complex, probably in conjunction with DID2, and VPS4 catalyzes the disassembly of the ESCRT-III complex.
What are the official names of this protein?
Vacuolar protein sorting-associated protein IST1, Increased sodium tolerance protein 1.
What is the protein family that this protein belongs to?
Belongs to the IST1 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome. Note=The endosomal location appears to be dependent on DID2.
Protein: SPC19_ASHGO
Sequence: MDISLDESCVALESSVKLLGKTLERLAEQGEHSRRLTSTLLRSKRVFELVSEYDLQRARLDVIEEVEPVVEKLCSKLEKSLNKLERERATLQQTYELNQLRLNNRLAGSGGRRPVVMGTSTTEELGRLREAKQRKAALEREIAEVRGT
What is the function of this protein?
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
What are the official names of this protein?
DASH complex subunit SPC19, Outer kinetochore protein SPC19.
What is the protein family that this protein belongs to?
Belongs to the DASH complex SPC19 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Protein: AROQ_SULNB
Sequence: MKIVVIQGPNLNMLGIREQNIYGPMKLEDIHKQMKGFAEQNKLEIEFFQSNLEGEIVDRIQECIGDADGIIINPAAYTHTSIAIRDAIAAVQLPTLEVHLSNIHQREEFRHKSLIAPVCAGQIVGMGPFGYHLAMVGMTQILSEVAAMREQQAKAQAAAQQK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: 5HT1A_PONPY
Sequence: MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTHHGASPAPQPKKSVNGESGSRNWRLGVESKAGGGLCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various drugs and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores.  Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism.  Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior.  Plays a role in the response to anxiogenic stimuli (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, Serotonin receptor 1A.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
Protein: BRD2_BOVIN
Sequence: MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSITSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVSAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGGLEPKAARLPPVRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTALPPGLAKSSSESSSEESSSESSSEEEEEEDEDEEEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPSQPKKSKKAGGGGSSGAATLGPPGFGPSGGGATKLPKKATKTAPPALPAGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKASEKTETSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
What is the function of this protein?
Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling.  Regulates transcription of the CCND1 gene.  Plays a role in nucleosome assembly (By similarity).  May play a role in spermatogenesis or folliculogenesis (By similarity).
What are the official names of this protein?
Bromodomain-containing protein 2.
What are the subcellular locations of this protein?
Nucleus. Note=Detected on chromatin and nucleosomes.
Protein: G6PI_TRIV2
Sequence: MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIANPDENRMVGHYWLRNPDLAPTPEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISIGIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDKILTHLRNNLASTLVLVISKSGGTPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQAEGWLATFPMYDWVGGRTSEMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDMVVLPYKDSLLLFSRYLQQLVMESLGKEKDLDGKTVYQGIAVYGNKGSTDQHAYVQQLREGVPNFFATLIEVLEDRNGASPEIDPGVTSGDYLSGFLLGTRQALYENQRDSITVTIPQVNARTVGALIALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALSLEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKVSIS
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIC62_ORYSJ
Sequence: MEQAAKATISLSPPSYAGCCMAACPYRSTRHLRRGGGCSARSISSLRHAPSARVYAAAAAAATPESKSTKENDLVFIAGATGKVGSRAVREFIKLGFRVRAGVRSAQRASSLVQSVEQLKVDDDATSPAERLEIVECDLEKQAQSDIVSAIGNAAIVVCSIGASEKDILDVTGPYRIDYMATNNLVQAATAAKVEHFILVTSLGTNRIGFPAFLLNLFWGVLCWKRRAEEALIGSGLPYTIVRPGGMERPTDAFKETHNLVVAVEDTYVGGLVSNLQVAELIACIASNRRTAYCKVVEAIAETTAPLLPTEDQLANIPSKRQPPPEPEVVQQGETPPKPIQQSQRPLSPYTAFVDLKPPSSPSPCPPSAAAPAPTSTDTAAAGSSSTLNSSATGTPISVDQPKQQQRPLSPYTRYEELKPPSSPSPTPPSAASSASVSASPDTPPAAAASSAALDSSANGTPITGDQLNQQQSPLSPYTRYEELKPPSSPTPSTPKL
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  Part of the redox regulon consisting of TIC32, TIC 55 and TIC62.  Acts as a membrane anchor of LFNR1 and LFNR2.  Has a NADPH-dependent dehydrogenase activity, but only after preincubation with lipids.
What are the official names of this protein?
Protein TIC 62, chloroplastic, Translocon at the inner envelope membrane of chloroplasts 62, OsTIC62.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Peripheral membrane protein. Plastid, chloroplast stroma. Plastid, chloroplast thylakoid. Note=Shuttles between the membranes and the stroma, depending on the redox state of the plastidic NADP(+)/NADPH pool.
Protein: CSG_METBF
Sequence: MKRFAAVTLAALMLLTVFASAASAADSVEIRGPVFNGSNIVEIVGDGITIDATQFAAFYYDIDDNVTTETLSIKDVSGNSGNVIGEGGIVYSTKIQKVDYEYYKPSLGWDNYSLLGFFAEKYIPLKSNSADKLAKLVIDSDDKITLRTGETLDIGQGYTLQAKQVDVDGEKVWLEFDRDGEYVDDEIIEVGADDSTWDVELDDIQDEDDVTVMRVHVNQVFQGAVDSIAQIEGIWLIDYANAMTIESDDEFGDLDDVSINGDTLNITNEDTFTLTRDSTNELAEGLSFKVADTSSNVLRFYLAKEFTDPGTYEVRGSVASGEASWDASNFAGFYYDLDDNVETESLSVSELNGNVIGEGGLVYTTSIKKVDYDYENEDAGWDQYPIIGFFAEEYIPLKANSADKLAKLVLDSDDKITLRTGETFDLGEGYSIQAKQVDVDGEKVWLEFDKDGEYVDDEIIEVGSNSDNTWDVELDDIEDEDDVVVLKVHVNQVFRGAVDSIAQIEGIWLIDYANAMTIESDDEFGDLDDVSIQGDTLKISNEDTFTLTRDSDEDIGEGMYFKVADTPTSELRYYPAIERIVGNETTSITKPDESGNETVSDNETMPDNTSSETPDLNETDTPEEPTTTPEEPTDNETEPDESNGSPGFGVVLGLAGLLGVVYLVRRNN
What is the function of this protein?
S-layer protein.  The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of the cell.
What are the official names of this protein?
Major S-layer protein, Cell surface glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the Methanosarcinales S-layer protein family.
What are the subcellular locations of this protein?
Secreted, cell wall, S-layer. Cell membrane.
Protein: PLSX_ANADE
Sequence: MVGKIAPIAVDAMGGDHAPGAIVQGAVNAARKGLPVVLVGPEARVREELARHRAGSSLPLEVHPATEVVEMHDHPGQAMRRKKDNSIRVCFDLVASGRAAGMVSAGNSGAVMAGAILVLGRPEGVERPAIVSVLPALKGSPLMLDMGAVVDCRPIHLVQFALMGEVFSRRVHGVARPRIAILSNGEEDTKGTDLTRAAAAALRRAPIDFVGYCEGRDLLTGEVDVIVTDGFTGNVALKTMEGTAKVVGEYLKRALRSTTVSKIGGLLSKAALEGMKKRIDWREVGGAPLVGVNGVGFISHGRSDALAIENAIRRAGDAARTHFIDEIARAVAPSHALLEVPANGAAAQQGPTPRRTAPPQT
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.