Protein: ACDB_ASPCN
Sequence: MTIRSAEEDPRRLLEEFNLTDNAATLGSCFPWLFEQAAHAHFDRTAVICGDAQLTYGTLNGRANIIAQILVNRNIGSGDVVGVALDRSVDLLVVLLAVMKSGAAYVPIDPALPAQRILQMMNDTAPKVVLTDHSVLDTLSLWNGPQLSIEELRVEMSLNPANTPNIRRDIQPEDLAYVIYTSGSTGKPKGVEISHGAVANFVLSMQVVPGCNKHDRILAVSTISFDMTLWDLYAPLACGACTVIAQTHEQKDAEALIELIRENGITSMLATPATWQMLFHAGWQGQPRLKTIKTGGESLSQHLSERLLAAAEKVYNGYGPTEATGCVSLWPVQAGEEVLIGTPIANTKLYVLDADLSPMPLGCAGELYIGGAGVACGYRNNPELTRSRFLANPFHEGLMYRTGDLACLVTPKKLKFLGRADSQVKIRGQRLELGEVEAAITSHGDVAHAIVINREGQLAAYCVRDLHRAVEIDPAKVSLSSILRPWLVERLPAYMVPSFIMEVDHIPLTLNGKVDHKSLPAPMAETTTTNQPATELERDIAAIWSTVLGHDHIGRDDNFFQIGGDSVRLVRMQADLKKLLGRSVPITVLFQQYTIKSLAGYLMDMDRPIPADESIHQPNPKPHHVDSDDIAVVSMACRLPGGIETPEAFWELLERGGDATTDVPPERWDADALYDPDPDAPGKSYCRRGGFVPSFGAFDTKFFHLLPNEARALDPAQYIMLETSWEAFERAGYRTQQLRGSSTGVFIGVNNTVAHGSPSTHAHGLADLQGYTGTGTAGGTMSGRVSYVLGLEGPSLTIDTACSSSLVATHLACTALRQGECDMAVTGAVTHLPAPGLHVEFSRLRGVAPDGRCRAFAADAQGIGIAEGAAVVVLKRLSDARRDGDTIYGVLRGSAVNHGGQGAAGLTVPSGAAQERVIRAALASSRLLPDDIDYIEAHGTGTRLGDPIEGMALTEVFGGSRSNTSQSLWIGSSKTNVGHTQAAAGLVGLIKVLLALRYNTLPPTLHITQPTPAIDWHRANMAPVQTKQHWLAGGERPRRAGVSSFGIGGTNAHVIVEEPPRCSVSTESTLYVPLPHPVPFLLSSPVEAGLQPQADKLHMYLSQSMSKGDPGNIAYSLATTRNHFPQRIVLLAQDTTDLVAQLVDLPRKAIVSPRGSSPEPRLAMLFAGQGSQQLGRGKTLAKHYRVFRETLEEIATQFYGILQEPLLDVMHAAADSALAALLQRSDYAQPALFALEVALWRLWQSWGVQPDMVLGHSIGELTAAHIAGVMDLPDACRLVAARGRLMETLPCHGGMASLEASASEVSLAITTLDLGGQVGIAAYNTPSQTVISGDRDALDILIAYFSGQDRQSKTLPVSRAFHSHHIDGMLTAYQAVVQSVQLNAPSLPIVSTLTGRRVEPCELQQPTYWVRQAREAVRYSDGIQALADHGMNVFLELGPQSVLCGMGAAVLDGSENRTTWLPSLAPNKDEVVAIQEILARLHVQHVPVNWQGYFQPFGCRRLELPTYAFQRERVHSGTKERDHGKREARPQASAFYDKVFQIDWRPFAIQHVQPRGIWGLQCSSGYVKWAEAVRAALFQGGIQCILLPSLSLQGTKTLDGVLCLWDSHGDVISQVHEFAAQGLTQLKEAANTRPSLPLVWLTSQAVGTARDDQPLALGAGLLWGLMRTARNEHPERSLRLIDLGRDDQNRVDASGLAPLLMLHTEPECALRQGMVLVPRMQRMELEFGDATQTLLRSDGAVLITGGLSGLGARIAEWLASTHGIRDLVLTSRRGMDTPGAATLVRRLAHLGTKTTVVSGDTTDPSHLNSLLSMFSHARPLRGVVHAAGVRDTSMLGTSTPQRCVGALAPKVIGAWYLHQFTRTRNDLDLFVVVSSFWGVMGTSGHATDAAANAVLDSLVYTRQSQGLPAVCVAYGPLPDINIPPGLLPTIRDQLQQMGIKTLTPDDTISLFELAARRSHGVTVAAALDLHQLQSYSSQRGGIPALLRLLLDRDTPQKHQGPALYDVLRRTAPDQRREILLRTIQEAVATTLGFSQPDEVDIHRSLPDMGIDSLGALLVRNQLAGLLGQALPANIVFIHPSLDELSRYLLPQLVDSNRDASSVAEPDMASASTAADVSGLNLMAIRKGCVDSSFTFDNALPKPTPQSVFVTGATEFVGAFLVHELLDQGKVTYCLVHAHSIDHARQQIVSWLQDYNLWKIGYAELLRPLVGDVCQVRLGLDESVFDDLAHRVDTIYHASCLVDWMRPLDDYIGPNVTSTHEVLRLASTSHAKTIHYLSTSATLPYHLGYDIPEDALTYGYAMSKLMAERMVIAARCRGAQAFIYRLPFITASATSGHFQLNNRDFLHNLISGSLEMGCFPSLDADLSLVFPVDYVCRTIITLAHTTPGSTHIRYDYDFKNPQAQSFDHYFNLLATVGKDLESLAFSTWRQRALAYAAAKPASSLTSIADILKNSTEEAVVKMFQCPPIVTPFLGGEEFPVPSVNDQSVRKYLHRMDLTL
What is the function of this protein?
PKS-NRPS hybrid synthetase; part of the gene cluster that mediates the biosynthesis of aspcandine, a pyrrolobenzazepine alkaloid (PubMed:35748771).  Initially, the indoleamine 2,3-dioxygenase acdA accepts L-tryptophan and performs the oxidative opening of the indole ring to yield N'-formyl-L-kynurenine, which undergoes the spontaneous deformylation reaction to provide L-kynurenine (PubMed:35748771).  The kynurenine 3-monooxygenase acdD then hydroxylates L-kynurenine to afford 3-hydroxy-L-kynurenine (PubMed:35748771).  3-hydroxy-L-kynurenine is activated by the A domain of the NRPS-PKS acdB and subsequently loaded onto the enzyme (PubMed:35748771).  The KS domain conducts the decarboxylative condensation of the 3-hydroxy-L-kynurenyl and malonyl moieties, and subsequent nucleophilic attacks by the two amino groups would occur nonenzymatically at two distinct positions, achieving the chain release and the construction of the tricyclic system (PubMed:35748771).  Finally, a dehydration reaction completes the biosynthesis to yield aspcandine (PubMed:35748771).
What are the official names of this protein?
PKS-NRPS hybrid synthetase acdB, Aspcandine biosynthesis gene cluster protein B.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.