PharMolix/UniProtQA huggingface dataset:
Protein: DPOL_HBVGO
Sequence: MPLSYQHFRKLLLLDDEAGPLEEELPRLADEGLNHRVAEDLNLQLPNVSIPWTHKVGNFTGLYSSTLPIFNPNWQTPSFPDIHLHQDIINKCEQFVGPLTVNERRRLKLVMPARFYPTSTKYLPLEKGIKPYYPQDVVNHYFQTRHYLHTLWEAGILYKRETTRSASFCGSPYSWEQELQHGAESFNQQSTRIFSRAPVGPCIQSKHQQSRLGLQPQQGQLAKGQRGRSGSVRSRAHSATRRSVGVEPSGSGHNNNSASESASCLHQSAVRQEAYSHFSTSERHSSSGHALELHDISPSSARSQSKGSVFSCWWLQFRNSIPCSGHCLSHLVNLLEDWGPCTEHGKHHIRIPRTPARVTGGVFLVDKNPHNTAESRLVVDFSQFSRGSTRVPWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHLPLHPAAMPHLLVGSSGLSRYVARLSSNSRIHDHQHGTMQNLHNYCTRNLFVSLMLLYKTFGRKLHLYSHPIVLGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLYTAVTNFLLSLGIHLNPTKTKRWGYSLNFMGYVIGSWGTLPQEHIVQKIKHCFRKIPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSPIYKAFLSKQYATLYPVARQRAGLCQVFADATPTGWGLVIGQQRMRGTFVAPLPIHTAELLAACFARSRSGANIIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGLSRPLCRLPFQPTTGRTSLYAVSPSVPSHLPDRVHFASPLHVAWRPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: Y293_METSB
Sequence: MRDADDRRAALWQGRMAERAAILALRLKRYAILERGYRIHGGEIDIIARRGDTIAFVEVKARPTMDGALQSITPQKRRRICRAARVWLASHPYAAAMTLRGDAVFVAPWRWPHHVAAAVELDFG
What are the official names of this protein?
UPF0102 protein Msil_0293.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: CYCA_TAKRU
Sequence: MGDIAKGKKIFVQRCSQCHTVTKEGRHKVGPNLWGLFGRKTGQAEGYSYTQANIEKGITWDEETLNVYLQNPKKYIPGTKMNFAGIRKKRERLDIIAYIKEATSK
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
What are the official names of this protein?
Cytochrome c-a.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: GCK1_CAEEL
Sequence: MTTTSSDELPRQADDDSMKWDRIYIQKLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILVDLIERAAEYRLRTGVSSDSDLDEDSDGGGGTSKWDYPTVRGPRVSADDDGTVRQRTDRPRAQVDRRSPSGSPGGTIVRGSPQVAAVAEQLRNSSVGSSGYGSGGNSASSQYATSSLPQSHTASSGGATTITLGSPNGSPTSSLARTQSMVSPSGQRSGSAQSWELERGNRPMSERVSSQVSPSKYNQHRTSSSNGVQGGSGGRREYINGSGSGLNGNSSNQNHSEYSDAVRQRGPGGSGGRLDYRESHVPTSSQENLNHGRMYGYGAPPPSREANNVPMPRVKGALDCSLLPAIEHLSRTRHATAALDQLRHVFRDVEDSCPGICNELIEELMQRIAVPQVSQSDLDAAIRRLTTPPS
What is the function of this protein?
Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis.  Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage (PubMed:19826475).  Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 (PubMed:25743393).
What are the official names of this protein?
Germinal center kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Apical cell membrane; Peripheral membrane protein. Note=Co-localizes with ccm-3 in the apical membrane of the excretory canals.
Protein: ATP6_BRANA
Sequence: MQIGLVAQSPLDQFEIVPLIPMNIGNFYFSFTNSSLFMLLTLSFFLLLIHFITKKGGGNLVPNAWQSLVELLYDFVLNLVKEQIGGLSGNVKQMFFPCILVTFLFLLFCNLQGMIPYSFTVTSHFLITLALSFSIFIGITIVGFQRHGLHFFSFLLPAGVPLPLAPFLVLLELISYCFRALSLGIRLFANMMAGHSLVKILSGFAWTMLCMNEIFYFIGALGPLFIVLALTGLELGVAILQAYVFTILICIYLNDAINLH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FUT8_BOVIN
Sequence: MRPWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHPDHSSRELSKILAKLERLKQQNEDLRRMAESLRIPEGPIDQGPASGRIRALEEQLVKAKEQIENYKKQTRNGLGKDHEILRRRIENGAKELWFFLQSELKKLKNLEGNELQRHADEFLSDLGHHERSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKAKKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESHNWRYATGGWETVFRPVSETCTDRSGVYTGHWSGEIKDKNVQVVELPIVDSLHPRPPYLPLAVPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKHPVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLATDDPSLLKEAKTKYPHYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQTLHPDASANFHSLDDIYYFGGQNAHNQIAIYPHEPRTADEIPMEPGDIIGVAGNHWDGYSKGVNRKLGRTGLYPSYKVREKIETVKVPHVPEAEK
What is the function of this protein?
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
What are the official names of this protein?
Alpha-(1,6)-fucosyltransferase, Alpha1-6FucT, Fucosyltransferase 8, GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase, GDP-fucose--glycoprotein fucosyltransferase, Glycoprotein 6-alpha-L-fucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 23 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Protein: AROQ_SHEB5
Sequence: MSHKILLVNGPNLNLLGRREPSVYGHQTLADIVAELKQQAKLAEVELEHIQSNAEFELINAIHATDAQMIIINPAAFTHTSVALRDALLGVAIPFFEVHLSNVHAREAFRHHSYFSDKAIGVICGFGSQGYEFALAAAIKRLNQPQ
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: COW3_CONCL
Sequence: MTRTAVLLLTLLFLVAMAASDKIKTRELCWSERECENGK
What is the function of this protein?
Probable neurotoxin.
What are the official names of this protein?
Contryphan-Cal3, O3_contryphan-like cal3.
What are the subcellular locations of this protein?
Secreted.
Protein: SYT_PROM2
Sequence: MPIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLLDATIPINSDSKVVIITSKDKEGIEIIRHSFAHLIGHAVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKIENRINKLIKTNYDVEILQVSKKEAIKTFKERDETFKLRIIEDIPEEGLINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELNDYLKRIEEAEKRDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTASENRTYAIKPMNCPCHIQVFNQGLKSYKDLPIRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFIDLVFEVYKTFGFDEIIIKLSTRPKKKVGSEEIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCGTIQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQLTLLSITDRNIEKCLKFNELLINNGYRSTVDIRNEKIGYKIREATLERVPLIAVIGDKEEEIDSVSLRALDGRNLGIFNLPNLCKLMDGLIEKRGRTE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_BACSU
Sequence: MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPTYTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKMLELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PTC_LEVBR
Sequence: MNMTKRDFIDTNTYTKEEIQYMIDLGIKIKESIKNGYYPPLLKNKTLGMIFEQSSTRTRTSAEAAMTELGGHAQYLAPGQIQLGGHETIEDTSQVLGRILDIIGARVERHHTVAEVGKFAKVPVVNFMSDYNHPTQELGDIITMTEHLPKGKKLSDCKIVFVGDATQVCVSTMFMATKMGMDFVQFGPKGFQIKPETLKIGQQNAKVSGGSVTITEDADEAFKDADFIYTDVWYGLYEAELSEEDRMKIFYPKYQVNAELVAKASDHVKFMHCLPATRGEEVTDEVIDSDYSIVWDEAENRKTAMRAIFVYLLNPELRKAQASQAVADKYDAEFSLMLRNAVDDQRNAD
What is the function of this protein?
Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine.  Is involved in the degradation pathway of the polyamine agmatine.
What are the official names of this protein?
Putrescine carbamoyltransferase, PTC, PTCase, Putrescine transcarbamoylase, Putrescine transcarbamylase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. PTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK1_BACAN
Sequence: MKFTIMSKGDQSSDTLASTMKEYLLDFGFIMDEQEPDIVISVGGDGTLLYAFHRYYNRLDETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIRYMNGSKESQYLAMNEATVKSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLKPTAGMNLQITVDHLTMVHQDVKSIQYRVANEKVRFVRFRPFPFWKRVRDSFVADK
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase 1, ATP-dependent NAD kinase 1.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PO4F3_DANRE
Sequence: MMTMNGKQHFSMHPALHPSSEGMRRVCLPAPQLQGNIFSGFDESLLARAEALAAADIVSHGKSHPFKTDVTYHTMSSVPCTSSSSTVPISHPSSNLPSHHHHHLSHQTLEGDLLDHISSSLSVSGMGAPPDPSVMTTQAHQHHLQMGHLHQAMAMGHPHTLSVHNGMACVNDVESDPRELEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNGKPDLFNGNERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
What is the function of this protein?
Acts as a transcriptional activator.  Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes.  May play a role in specifying terminally differentiated neuronal phenotypes.
What are the official names of this protein?
POU domain, class 4, transcription factor 3, Brain-specific homeobox/POU domain protein 3.1, Brain-3.1, zfBrn-3.1.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-4 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Preferentially localized in the nucleus.
Protein: RN185_PONAB
Sequence: MASKGPSASSSPENSSAGGPSGSSNGAGESGGQDSTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVDEQFLSRLFLFVALVIMFWLLIA
What is the function of this protein?
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1.  Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation.  Protects cells from ER stress-induced apoptosis.  Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway.  Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity.  Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF185, RING finger protein 185.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NACA_ORENI
Sequence: MPGEATETVPVTEQEMQQPQVETGSGTESDSDDSVPELEEQDSAQTQTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVPGETVSNVQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNNNDIVNAIMELTM
What is the function of this protein?
May promote appropriate targeting of ribosome-nascent polypeptide complexes.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: RL24_ECO55
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: SYE_MYXXD
Sequence: MPPALRVRFAPSPTGYLHIGGARTALMNFLQARRQGGTFVLRMEDTDQGRSTPESVQAILDGLNWLGIDWDEGPGKEGPYAPYFQMQRLDTYRKHADQLIAEGKAYRCYCTKEDLDAQRQVAEKAGGAFKYPGTCRERTEPPAGRNAADAVIRFKMPAGDGSVSFTDKALGTITKTHSDLDDWVMMRADGIPVYNFGCVIDDHLMDITLVARGQEHVNSTFPQLMLYQALGWTPPDFAHLPLILGPDREKLSKRKHPEADVMVHKRNGVMPEALLNFVIRLGWSHGNDEVISREQMLEWFDFSDVGTTSGVWNPEKLLWLNQQWMKQLPVETVVERLLPFLEAKGIQAKGDPRLETLVRTLRERSNTLEDIATTAANVYFRSGITLDEKAATKHLSGESLNLLRKVRETLTALPEWSVEALDGVVKQVSEASSVGMGKVAQPIRVALTGNTTSPGIGETLVLVGRDESLLRIDAALTRG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLO2_SHESW
Sequence: MLTITAIKAFNDNYIWVLQQTPHSQVYVVDPGDAKVVIAYLVSHQLALAGILLTHHHQDHTGGVGELKRYVEQTSSQTLQVYGPQKENIAHVNVPLNPEMRTELTLPFLNAQIQVLNVPGHTAGHIAYVIEDALFCGDTLFSAGCGRLFEGTAEQMLSSLTLLAKLPANTRVFCAHEYTLSNLKFALTVEPNNLNLQAYMQKATEMRAQNSATIPSSIALERAINPFLRVGEQSIIDSIKQHFDDPDPIKLDELTCFTRLRQWKDIF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: PDC6I_XENLA
Sequence: MATFISVPLKKTSEVDLVKPLSKYIHNTYPSGEDQTEYCRAVDELNKLRKSAVGRPLDKHETSLETVMRYYDQLCSVEPKFPFTESQLCLTFTWKDAFDKGSIFGGSVKLALPSLGYEKTCVLFNIGALASQIASEQNLDNDEALKAASKFYQLASGAFSHIKDTVLSSLNRDPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAVIAKLANQAADYYGDAFKQCQYKDTLSKEVFPILAAKHCIMQAHAEYHQSVLAKQQKKFGEEIGRLQHASDLVKTVSSRYDEYVNVKDLADKINRALTAAKKDNDFIYHDRVPDLKDLDPVGKASLVKSTPVNVPLSQKYTDLFEKMVPLAVQQCLSVYNQRKSELINSTIAQMRDATIFANGVLASLNLPAAVEDVSGDSIPQSILNKSKTVIEQGGIQTIGQLIRDLPELLQRNKEILEESLKFLDEEEATDNDLKAKFKDRWQRTPSTELYKPLRSEGSNFRNVLDKAIGADAVVKERYQSHREAIVILCKPEAELNAAIPSANPAKTMQGSEVVTVLKSLLNKLDDMKKEREQLENDIKSVNFDMTTKFLTALAQDGAVNEEAISVTELDQIYGSYTYKVQENLKKQEDLLNNIQSAHQEFSKMKQSNSEANLREEVLKNLAVGHDNYIELVANLKEGTKFYNDLTDILLKFQCKCSDIVFARKTERDELLKDIQQSIAREPSAPSIPQVPSYQSAPSSISTNIATSSIPTPAPRTVFSAKQPPPRPPPPAMPSASPVPASAAQASNPAPTAAADSSQPPSNTIPSQAQGPPYPSYPGYPGYYGMPMPVGYNPYMYGQQTIPPYMYQPPSGQPPYPAQQPSFSYPQQPFFPPQ
What is the function of this protein?
Multifunctional protein that may be involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity.  Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles that are generated by invagination and scission from the limiting membrane of the endosome (By similarity).  Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes.  May play a role in the regulation of both apoptosis and cell proliferation.  Regulates exosome biogenesis in concert with SDC1/4 and SDCBP.  Ensures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).
What are the official names of this protein?
Programmed cell death 6-interacting protein, Signal transduction protein Xp95.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Secreted, extracellular exosome. Cell junction, tight junction. Midbody, Midbody ring. Note=Component of the actomyosin-tight junction complex (By similarity).
Protein: RS2_BACAA
Sequence: MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQKTVKKVEEAFKVMRDIAAEGGDILFVGTKKQAQEAIKEEATRAGMYFVNQRWLGGTLTNFQTIQKRIKRLKDIERMQEDGTFEVLPKKEVVQLKKELERLEKFLGGIKDMKGLPSALFVVDPRKERIAVAEARKLHIPIIGIVDTNCDPDEIDHVIPANDDAIRAVKLLTSKMADAILEAKQGEETVTA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: MURE_STRP2
Sequence: MIKIETVLDILKKDGLFREIIDQGHYHYNYSKVIFDSISYDSRKVTEDTLFFAKGAAFKKEYLLSAITQGLAWYVAEKDYEVDIPVIIVNDIKKAMSLIAMEFYGNPQEKLKLLAFTGTKGKTTATYFAYNILSQGHRPAMLSTMNTTLDGETFFKSALTTPESIDLFDMMNQAVQNDRTHLIMEVSSQAYLVHRVYGLTFDVGVFLNITPDHIGPIEHPSFEDYFYHKRLLMENSRAVIINSDMDHFSVLKEQVEDQDHDFYGSQFDNQIENSKAFSFSATGKLAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAATRVPGRMEVLTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLNQHPEIQVFLTADDPNYEDPMAIADEISSYINHPVEKIADRQEAIKAAMAITNHELDAVIIAGKGADCYQIIQGKKESYPGDTAVAENYL
What is the function of this protein?
Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase, L-lysine-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:L-Lys ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRVP_TRIPP
Sequence: PRNPEIQNEIIDLHNYLRRSVNPXASNMLRSQW
What is the function of this protein?
Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction.  May target voltage-gated calcium channels on smooth muscle (By similarity).
What are the official names of this protein?
Cysteine-rich venom protein tripurin, CRVP.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: FOXB1_XENLA
Sequence: MPRPGRNTYSDQKPPYSYISLTAMAIQGSQEKMLPLSEIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALHPRCGDMFENGSFLRRRKRFKVMKSDHLAPSKASDAAQYLQQQAKLRLSALAASGTHLPPMSTYNLGVSPTSSFKHPFAIENIIAREYKMPGGLAFSTMQPMPAAYPLHNQLTTVGGSIGTGWPHMYSSSMLDSTTPISMANSDYSVSAYGVPIKPICHGAQTLLPAIPVPIKPTAALPALPTHIPAILSNSSPSMSPTSPQTATSQSSPATPSDTLTNPSTALLSVAVH
What is the function of this protein?
Probable transcription factor.  May be involved in the early anteroposterior patterning of the neuroectoderm.
What are the official names of this protein?
Forkhead box protein B1, FoxB1, Transcription factor FKH-5.
What are the subcellular locations of this protein?
Nucleus.
Protein: MB3L4_HUMAN
Sequence: MGEPAFTSFPSPPVLGKLKRNMMPWALQKKREIHMAKAHRRRAARSALPMRLTSCIFRRPVTRIRSHPDNQVRRRKGDEHLEKPQQLCAYRRLQALQPCSSQGEGSSPLHLESVLSILAPGTAGESLDRAGAERVRIPLEPTPGRFPAVAGGPTPGMGCQLPPPLSGQLVTPADIRRQARRVKKARERLAKALQADRLARQAEMLTCR
What are the official names of this protein?
Putative methyl-CpG-binding domain protein 3-like 4, MBD3-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the MBD3L family.
Protein: HRDC_STRCO
Sequence: MAPTARTPTARTRDDRRATTRTARLRTRIPEPDEEPDLLGQYLTQIGATPLLTAEDEVRLATRIEAGVRAREELETADTGEPAPTPRRRRTLEETVHDGQEAKDHMVRANLRLVVSMAKRHAHRGLPLLDVIQEGNLGLIRAVEKFDHTKGFKFSTYATWWIRQAIERGLATHARTVRLPVHVVEQLQKLAKVERKLRAGLDREPTTEEVAAESGIDVDKVVWLRRVGRDAVSLDTPVDETGDTVVGDLIPDTEVLRAPEVAEFQALAAELREAVGTLAPRESLILSLRYGLHDGRPRTLQQVAQHVGLTRERVRQLEKESLAHLRAPENRERLLDWAS
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
What are the official names of this protein?
RNA polymerase principal sigma factor HrdC.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: RL6_YERPY
Sequence: MSRVAKAPVVIPAGVEVKLNGQVISIKGKNGELTRTVHSAVEVKQEENTLTFAPREGAVDGWAQAGTTRALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVVNLALGFSHPVDHELPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.