PharMolix/UniProtQA huggingface dataset:
Protein: TXI12_DIGCA
Sequence: AKDGDFEGPPGCLKMGELCKGGTCCTKVYKYWKWRKLECLGKNDGWFKKKFICDEPCNPXX
What is the function of this protein?
Acts by delaying the inactivation of presynaptic voltage-sensitive sodium channels (Nav).  Acts against insects and causes a progressive spastic paralysis.
What are the official names of this protein?
Mu-diguetoxin-Dc1c, Mu-DGTX-Dc1c, Insecticidal toxin DTX12.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 26 (DTX) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PEPT_SALPA
Sequence: MDKLLERFLHYVSLDTQSKSGVRQVPSTEGQWKLLRLLKQQLEEMGLVNITLSEKGTLMATLPANVEGDIPAIGFISHVDTSPDFSGKNVNPQIVENYRGGDIALGIGDEVLSPVMFPVLHQLLGQTLITTDGKTLLGADDKAGVAEIMTALAVLKGNPIPHGEIKVAFTPDEEVGKGAKHFDVEEFGAQWAYTVDGGGVGELEFENFNAASVNIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADEAPETTEGYEGFYHLASMKGTVDRAEMHYIIRDFDRKQFEARKRKMMEIAKKVGKGLHPDCYIELVIEDSYYNMREKVVEHPHILDIAQQAMRDCHITPEMKPIRGGTDGAQLSFMGLPCPNLFTGGYNYHGKHEFVTLEGMEKAVQVIVRIAELTAKRGQ
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_HALH5
Sequence: MSLHREPTATEVKEQKIYREMGLTDEEFALVESILGRLPNYTETGLFSVMWSEHCSYKNSKVLLKKFPIDGDKVLQGPGEGAGIIDIGDEQAVVFKIESHNHPSAIEPYQGAATGVGGILRDVFSMGARPISLLNSLRFGELTSPKVRYLFEEVVAGIAGYGNCVGVPTVGGEVQFDPCYEGNPLVNAMCVGLIDHKDIQKGQAKGVGNTVMYVGASTGRDGIHGATFASEELSEASEEKRPAVQVGDPFMEKLLLEACLELIKSDALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDHVPQREKGMTPYEMMLSESQERMLIVVKKGREQEIKDIVAHWGLHAVEVGQVTDDKKLRLLHKGEVVADVPVDALAEDAPVYHKPSKVPAYYEAFQSEKTQWIPTIANVKDTLLSLLQQPTIASKEWVYEQYDYMVQTNTVVSPGSDAAVVRIRGTKKALAMTTDCNSRYLFLDPEVGGKIAIAEAARNIVCSGGVPLGVTDCLNYGNPEKPEIFWQLEKSTDGMSEACRELGTPVIGGNVSLYNETNGVAVYPTPVIGMVGLIEDVGHITTQAFKKAGDLIYVIGEAKAEFGGSELQKLVNGEISGKAPAIDLAVEKKRQEQLLEAIRAGAVASAHDIAEGGLAVALAESMMGEAVGADVVIDGEWTTELFAESQSRFLVSVPKEKQAIFESLVEDAIHLGQVTDHPQLNIQDVNGAQVLQASVNEMLEAWKGAIPCLLKSKA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
Protein: LACB_STRZT
Sequence: MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPIFGKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNANVIGFGGKITGELLMCDIIEAFIHAEYKPSEENKKLIAKIEHVETHNAQQTDANFFTEFLEKWDRGEYHD
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacB.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: YLXG_ALIFS
Sequence: MISKWAKRFFQMAELVGSWSKDPSTQVGAVITKHNRIVSVGFNGYPHGVSDSADTDEREIKYLKTLHAEENAILFAKRDLEGCDIWVTHFPCPNCAAKIIQTGISKVYCPEQTEDFLSRWGEKIQVSQDMFSQAGVEVTWLPLDILK
What are the official names of this protein?
Uncharacterized deaminase in luxG 3'region.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: RS6_PROM1
Sequence: MSETPYYETMYILRPDIPEEEVDSHLKKYSAILEKSETEVLDSQMRGKRRLAYPIAKHKEGIYVQLSHKGNGQQVATLERAMRLSEDVIRYITVKQDGPLPTPKPTSKEDETEKEEVKPTEDKTESPAQEEKKEDSKE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: SKA1_CAEBR
Sequence: MEAFMVSFERQKDAKFCMYRENIPNFESTLSSITKSTNSIKILLEDISNVQKVITDPCEQSCSSCSPNVLNKFLGIEEKLVNNVEIPDSVPQKSTRPCLDDEKEGSSVVQPPESGNRHVQLISEQEFKSIPKYQLGRLTLDNLNEIVGKMDEFLTKKNAILGKTNKQITRQDREVLDNWRELEIKAKGRLPTTLFFIENDIRPLLTERLRLSFAKAIPCLRHIRRVREERCGPLTFYYA
What is the function of this protein?
Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint.  The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies.  The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner.  Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.  In the complex, it mediates the interaction with microtubules.
What are the official names of this protein?
Spindle and kinetochore-associated protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SKA1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Protein: DGTP_YERPP
Sequence: MSGIDFKQKISFQRPFSKPSSAEDEYEITRVFESDRGRIVNSAAIRRLQQKTQVFPLERNAAVRSRLTHSLEVQQVGRYIAKEILNRFKQDKKITAYGLDKLLDPFESIVEMACLMHDIGNPPFGHFGESAINDWFTKRMDPNGGSGSEPQSTDQCQVDVLKLCEGETELNILRSKIRHDLSQFEGNAQAIRLVHSLLKLNLTYAQVGCILKYTKPAYWSAPIPASHNYLMKKPGFYLAEENYVKELRRELNMEEFDRFPLTYIMEAADDISYCIADLEDAVEKNIFSVEQLYDHMSQEWGAVTPGDLFDKVVGAAFRQLGREQGRRSSEDQFFMYLRVNTVGKLVPHAAQRFIENLPAVFSGSFNQALLEDSSAACKLLQIFKRVAVKHVFNHPEVEQLELQGYRVISGLLDIYSPLLAMPETAFTQLVADDRHRKYPIETRLFHKLSIKHRLAYAESAERIRNLPSEQYEIYEYYYRARLIQDYISGMTDLYAYDEYRRLMAAE
What is the function of this protein?
dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase, dGTP triphosphohydrolase, dGTPase.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 1 subfamily.
Protein: Y2868_BACLD
Sequence: MSSFDKTMKFNFSDDSMETNVNEVLITVHDALQEKGYNPINQIVGYLLSGDPAYIPRHRDARNLIRKIERDEIIEELVKSYLEQHKEA
What are the official names of this protein?
UPF0297 protein BLi02868/BL02032.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: YDAN_BACSU
Sequence: MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQVLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPVKTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPDSRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKTVDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVLKAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLTLENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESASQAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKENNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVSQSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSDLLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEIISYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIMVVAAVFIWIAVRRKKRKTDTE
What are the official names of this protein?
Uncharacterized protein YdaN.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: METK_METB6
Sequence: MKRNIQIEALNQIPLEKQRIELVERKCLGHPDSIADGIAESISQALCREYLKEFGAVLHHNTDQGEVVAGESCPKFGGGKMIRPIYVLIDGRATKQFNGVTIPTDTVAVEAAHEYLHKILPELNLQRDVMIDSRLGTGSTDLRDVFKPRQGKVPRSNDTSFGVGHAPFSDVETIIRNTSEYIDTKLRKKYPAIGQDIKIMGLRDGNTITLTVACAIVDRYCADIREYQEYMGLLTEEIGKVAKKSTKRKVVVNLNTADDIKSKSVFLTVTGTSAEMGDDGSVGRGNRCNGLITPNRPMSMEATSGKNPINHIGKIYNLLSTQIAQESIKKVDGIEEMYVRLLSQIGKPIDQPLVASVQVLPRKGVTLQEINGEIQAIVDDNLANVTSITEKVIRGELKTF
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase 2 family.
Protein: ONCO_MOUSE
Sequence: MSITDILSADDIAAALQECQDPDTFEPQKFFQTSGLSKMSASQLKDIFQFIDNDQSGYLDEDELKYFLQRFQSDARELTESETKSLMDAADNDGDGKIGADEFQEMVHS
What is the function of this protein?
Has some calmodulin-like activity with respect to enzyme activation and growth regulation.  Binds two calcium ions.
What are the official names of this protein?
Oncomodulin, OM, Parvalbumin beta.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: EFP_TREPA
Sequence: MIRGGDIAKGTVLLHKGAPYLVVEREFVNPGKGAAFARVKMKHLRDGSVLTQTVKTSDTVEDAVVDSHRAQYQYDDGECFVFMDTRSFEQIFVSKGNVPGRERYLREGDEYDILIWNGESIDIKIPTKMVFRVAHSEPYLKGDTVSGATKPVTTETGLVVRVPLFIKQGEKILINTETNEYQERVND
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_PASMU
Sequence: MAIILGIDPGSRVTGYGVIRQAGRHLEYLGSGVIRTSVTDLPTRLKRIYMGVNEIILQYQPDMFAIEEVFLAKNANSALKLGQARGAAIVAAVNHDLPVFEYAARLVKQTVVGIGSADKIQVQDMVTRILTLSEKPQADAADALAIAITHAHSLQHAFHVTNSAQATEKPEKTTALLKARYSRGRFRLKI
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: MHPB_ECO55
Sequence: MHAYLHCLSHSPLVGYVDPAQEVLDEVNGVIASARERIAAFSPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPVELAEACAHAVMKSGIDLAVSYCMQVDHGFAQPLEFLLGGLYKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFTSTLNKRVLFLGSGGLSHQPPVPELAKADAHMRDRLLGSGKDLPASERELRQQRVISAAEKFVEDQRTLHPLNPIWDNQFMTLLEQGRIQELDAVSNEELSAIAGKSTHEIKTWVAAFAAISTFGNWRSEGRYYRPIPEWIAGFGSLSARTEN
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: MATK_JASNU
Sequence: MQEIKRYLQLDRPQQHDFLYPLIFQEYIYALAHDRGFNRSSLLENPGYDNKSSLLIVKRLITRMYQQNHFWISSNDSNQNPFFGRNKNLYPQILSEGFAFILELPFSLRLILSLERKKKKIVKSQNLRSIHSIFPFLEDNFSHFPFVLDILIPHPIHLEILVQTLRCWVKDASSLHLLRFFLHEYWNWNSLSTPKKASSSFSKRNQRLFFFLYNSHVCEYESIFVFLRNQSSHLRSTSSGALLERIYFYGKIERLVNVFLKDFQINLCLLKDPFMHYVRYQEKSILASKGTPLFMTKWKYYLVPFWQCYFSLWFHPRRIYLNQLSKNFLEFGGYLSSVRLNASVIRSQILENSFLINNAINKFDTFVPIIPLIGSLAKAQFCNVLGYPISKLVRTDLSDSDIIDRFGRICRNLSHYHSGSSKRKSLYRIKYILRLSCARTLARKHKSTVRAFLKRLGSELLEEFLMSEEQVLSLTFPKASSTLRGVYRSRIWFLDIICLHDLVNQK
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HXC9_HUMAN
Sequence: MSATGPISNYYVDSLISHDNEDLLASRFPATGAHPAAARPSGLVPDCSDFPSCSFAPKPAVFSTSWAPVPSQSSVVYHPYGPQPHLGADTRYMRTWLEPLSGAVSFPSFPAGGRHYALKPDAYPGRRADCGPGEGRSYPDYMYGSPGELRDRAPQTLPSPEADALAGSKHKEEKADLDPSNPVANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQNRRMKMKKMNKEKTDKEQS
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-C9, Homeobox protein Hox-3B.
What is the protein family that this protein belongs to?
Belongs to the Abd-B homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: STML3_MOUSE
Sequence: MDSPEKLEKNNLVGTNKSRLGVCGWILFFLSFLLMLVTFPISVWMCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQTTLRNVLGTQTLSQILSGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEATREARAKVLAAEGEMNASKSLKSASMVLAESPVALQLRYLQTLTTVATEKNSTIVFPLPMNILEGIGGISYGNNKKVTAKA
What is the function of this protein?
Required for the function of many mechanoreceptors.  Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins.  Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.
What are the official names of this protein?
Stomatin-like protein 3, SLP-3, Stomatin-related olfactory protein.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein. Note=Detected in lipid rafts, in apical dendrites and in olfactory cilia.
Protein: MDREP_MYCTU
Sequence: MRTNCWWRLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRVIDDAIAADHRPLAPWAVVLVAAAGATYLLMYVRRYYGGRIAHLVQHDLRMDAFQALLRWDGRQQDRWSSGQLIVRTTNDLQLVQALLFDVPNVLRHVLTLLLGVAVMTWLSVPLALLAVLLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERETVKLVTASRALYAAQLRVARLNAHFGPLLQTLPALGQMAVFALGGWMAAQGSITVGTFVAFWACLTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGTKPLSPEARLSLEFQRVSFGYVADRPVLREISLSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVRELTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIEEFVNTLPDGYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVDAVIECGIQEVLREAIADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVGTPDEVWERCPRYRELLSPAPDLADDLVVAERSPVCRPVAGLGTKAAQHTNVHNPGPHDHPPGPDPLRRLLREFRGPLALSLLLVAVQTCAGLLPPLLIRHGIDVGIRRHVLSALWWAALAGTATVVIRWVVQWGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLRTGLVVAVISVVTLVGILVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRARHRLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVALLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAAVAAGRIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTVVFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAGTVRDAIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALARARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLEHGTVVEDGAHTELLAAGGHYSRLWAAHTRLCSPEITQLQCIDA
What is the function of this protein?
Overexpression in M.  smegmatis increases resistance to erythromycin, ampicillin, novobiocin and vancomycin.  It also reduces accumulation of ethidium bromide in the cell.
What are the official names of this protein?
Multidrug efflux ATP-binding/permease protein Rv0194.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HCY5_HOMAM
Sequence: GAGEALNAKRQQDVNHLLDLIYDHLHY
What is the function of this protein?
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
What are the official names of this protein?
Hemocyanin subunit 5.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family. Hemocyanin subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: HIS2_BURTA
Sequence: MTQPTIEDTLLRLAAVIDSRKGGDPEQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQGGAPSALVGEVADLWFHCLVALSHFDLSPADVIAELERREGMSGIEEKALRKRREREENGG
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROF1_DICDI
Sequence: MSWQQYVDEQLTGAGLSQGAILGANDGGVWAKSSGINITKPEGDGIAALFKNPAEVFAKGALIGGVKYMGIKGDPQSIYGKKGATGCVLVRTGQAIIVGIYDDKVQPGSAALIVEKLGDYLRDNGY
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG.
What are the official names of this protein?
Profilin-1, Profilin I.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: APT_AERS4
Sequence: MNPETLKFIEASIKTIPDYPKPGILFRDITSLIENAEAFKATIDLLAEHYRDQGITKIVGTEARGFIFGAPVAFAMGLGFVPVRKPGKLPRAVIEESYALEYGTDTLQLHTDAIVPGDKVLVVDDLLATGGTVDATVKLIRRAGGEVADAAFIISLPSLGGDARLTAAGIKVVSLVELAGE
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_BOVIN
Sequence: MNENLFTSFITPVILGLPLVTLIVLFPSLLFPTSNRLVSNRFVTLQQWMLQLVSKQMMSIHNSKGQTWTLMLMSLILFIGSTNLLGLLPHSFTPTTQLSMNLGMAIPLWAGAVITGFRNKTKASLAHFLPQGTPTPLIPMLVIIETISLFIQPMALAVRLTANITAGHLLIHLIGGATLALMSISTTTALITFTILILLTILEFAVAMIQAYVFTLLVSLYLHDNT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NRDR_BRUA2
Sequence: MRCPYCQSEDTQVKDSRPAEDGAVIRRRRVCSVCGGRFTTFERVQLRDLMVVKKSGRRVPFDRDKLTRSIEVALRKRDVDSERVERAISGIVRQLESAGEAEVTSDEIGRLAMDALKGIDDIAYIRFASVYRNFSKAVDFHNVIDELTVSETGDNLET
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: NU2C_ACAM1
Sequence: MDVANLASQLNATTILPEGVLVISLILVLLGDITFGRSSAKWTPYLAIASLAACLYLLYTQWDQANPIGFLGSFNADNLSIVFRAIIALSTLVTILMSVRYIEQSGSSIGEFMTVLLTATVGAMFLCGAEELVMIFISLETLSIASYLMTGYMKRDSRSNEAALKYLLIGAASSAVFLYGLSLLYGLSGGKTHLDDIALALTDTSKSLALVISLVFVIASVSFKIAAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAGFALAIRLLTQAFPNLVEQWQFIFTALAILSMVLGNVVAIAQTSMKRMLAYSSIGQAGFVMIGLVIGTEAGYASMVFYLLIYLFMNLGAFTCVILFSLRTGTDEIGDYAGLYLKDPLLTLALSLCLLSLGGIPPLAGFFGKLYLFWAGWQAGAYGLVLLGLITSVVSIYYYIRVIKMMVVKEPQDMSEVIKNYPSIVWKPLGMRPLQVGLVLTLIATSLAGVLSNPLLTIVNSSVADVPRFKQATIPTSIDVAIQPDTPTIAPEL
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2, NAD(P)H dehydrogenase subunit 2, NADH-plastoquinone oxidoreductase subunit 2, NDH-1, subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: RECU_STRP4
Sequence: MVNYPHKVSSQKRQTSLSQPKNFANRGMSFEKMINATNDYYLSQGLAVIHKKPTPIQIVQVDYPQRSRAKIVEAYFRQASTTDYSGVYNGYYIDFEVKETKQKRAIPMKNFHPHQIQHMEQVLAQQGICFVLLHFSSQQETYLLPAFDLIRFYHQDKGQKSMPLEYIREYGYEIKAGAFPQIPYLNVIKEHLLGGKTR
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_LACJO
Sequence: MNIKIVCVGKLKEKYFKDGIAEYVKRMSRFAKVKIVQVPDEKAPEKLSPAEMEQVKEIEGKRILDKIKDKEYVYVTAIKGKERTSEAFAKELSDLTTYGHSDITFVIGGSLGTSDAVNKRADDLISFGKFTMPHQLMRLVLIEQIYRAFMINSGSPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.