PharMolix/UniProtQA huggingface dataset:
Protein: SUH_CIOIN
Sequence: MYHPHHLPAHGQVQSHQHREDAAATSSRDVNGGLSVTESAIASFRSLREKYPPKKLTRDAMRRYLKDPNDQTLIVLHAKVAQKSYGNEKRFFCPPPCMYLLGNGWKRKQQILEEEEGSSEAGQLHAFIGIGSSEQEMQQLHLDGKNFCTAKTLYISDTDKRKHFMLNVKMFFGGGGADVGQFSSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEKGNFHASSIQWGCFAIHLLDDDESESEEFSVVDGYIHYGQTVKLVCSNTGMALPRLIIRKVDKQTAILDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKETNKEMINDGASWTIISTDKAEYTFCDGMGPTADPVTPVPNVHSLQLNGGGDVAMLEVNGECFTSNLKVWFGEIEADTMFRCAEGLLCVVPDISAFREGWKWVKESVQVPINLVRNDGVIYPTNLTFTFTPEPGPRQHCPAALNILHGSKRPSASMPPTPVSGSEDDSGRGNESDRGDPIMPIKRPALDVHGRPVAPEAAATMNGANMLRTAS
What is the function of this protein?
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations.  Acts as a transcriptional repressor when it is not associated with Notch proteins.  When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity).  Required for the transcriptional expression of Brachyury, suggesting that it participates in notochord differentiation.
What are the official names of this protein?
Suppressor of hairless homolog, Su(H).
What is the protein family that this protein belongs to?
Belongs to the Su(H) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNC_AZOVD
Sequence: MSASLNRLERKLGHTFKNQDLMLLALTHRSFASRNNERLEFLGDAILNFVAGEALFERFPQAKEGQLSRLRARLVKGETLALLARGFDLGDHLRLGSGELKSGGFRRESILADALEALIGAIYLDAGLNTVRERVLGWLAGELDSLTLVDTNKDPKTRLQEFLQSRACELPRYEVVDIQGEPHCRTFFVECRVALLNDKTYGQGASRRIAEQVAAAAALVALGVENGND
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WNT7A_ALOVU
Sequence: SGSCTTKTCWTMLPKFRELGYILKEKYNEAVQVEPVRTHRNKRPVFLKIKKPLSYRKPMVTDLVYIEKSPNYCEEDPITGSVGTQGRMCNKTSSQNNSCDLMCCGRGYNTHQYSRVWQCNCKF
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).  Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development.  Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).
What are the official names of this protein?
Protein Wnt-7a.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: ZC21C_MACFA
Sequence: MAGLQRLASHLPVGVMLPHNTTEAPGPHSAKQDSYEQSDSSQQSLKGHLRNNFQKQLLSNKELTLDKVHTHPKWNTKARSYSYPHCTGISHQDAGSDFQGQGNGLFYSSGPQSWYPKANNQDFIPFTKKRVGVDRAYPLKPVVHRKSCSTGESGTDGDQNVYPRPPELREFSSRNFDVRNQVNFSVVDPVLAAMQAEKALANLDRMEWVQIRRLEAAGESLEEEIRRKQILLRGKLKKTEEELRRIQTQKEQAKENENRELQKIIFPRSRVKGNNSNTTHKAVFSPEFDFEEEFSRDKREDETWERSQQNSSPFQLSDYRIQRLKRERLVASNNKIRDRVSEPSMEKFSPPSETPGGALQGSARNSSLSMAPDSSGSSGSTEEPQLGECSHCGRKFLLFRLERHSNICSRMQGSKRKVFDSSRARAKGTELEQYLNWKGPASAKAEPPRKNNWRQKHESFIHTLRQAREVQQVTAKGENRSHLPPILPAENPDYIQCPHCSHHFAPKVAEQHIPKCKTIKNRPPPPRKHYS
What are the official names of this protein?
Zinc finger C2HC domain-containing protein 1C.
What is the protein family that this protein belongs to?
Belongs to the ZC2HC1 family.
Protein: 6PGD_DROSI
Sequence: MSGQADIALIGLAVMGQNLILNMDEKGFVVCAYNRTVAKVKEFLANEAKGTNVIGADSLKDMVSKLKSPRKVMLLVKGGSAVDDFIQQLVPLLSAGDVIIDGGNSEYQDTSRRCDELAKLGLLYVGSGVSGGEEGARHGPSLMPGGHEAAWPLIQPIFQAICAKADGEPCCEWVGDGGAGHFVKMVHNGIEYGDMQLICEAYHIMQSLGLSADQMADEFGKWNSAELDSFLIEITRDILKYKDGKGHLLERIRDTAGQKGTGKWTAIAALQYGVPVTLIGEAVFSRCLSALKDERVQASSVLKGPSTKAEVANLTKFLDDIKHALYCAKIVSYAQGFMLMREAARENKWRLNYGGIALMWRGGCIIRSVFLGNIKDAYTSQPQLSNLLLDDFFKKAIERGQDSWREVVANAFRWGIPVPALSTALSFYDGYRTAKLPANLLQAQRDYFGAHTYELLGQEGQFHHTNWTGTGGNVSASTYQA
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.
Protein: HRCA_STRPD
Sequence: MITQRQNDILNLIVELFTQTHEPVGSKALQRTIDSSSATIRNDMAKLEKLGLLEKAHTSSGRMPSPAGFKYFVEHSLRLDSIDEQDIYHVIKAFDFEAFKLEDMLQKASHILSEMTGYTSVILDVEPARQRLTGFDVVQLSNHDALAVMTLDESKPVTVQFAIPRNFLTRDLIAFKAIVEERLLDSSVIDIHYKLRTEIPQIVQKYFVTTDNVLQLFDYVFSELFLETVFVAGKVNSLTYSDLSTYQFLDNEQQVAISLRQSLKEGEMASVQVADSQEAALADVSVLTHKFLIPYRGFGLLSLIGPIDMDYRRSVSLVNIIGKVLAAKLGDYYRYLNSNHYEVH
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: CRIE_ASPCR
Sequence: MWDSPIIFTRMRELVQSVSPAALSWAVVAVYIGTFFWLKSRSSKQRLPLPPGPRGLPLIGNSFQTPAVNPWEKYKEWSDEYGPVMTLSLGLTTTIILSSHQVANDLMEKKSTIYSSRPQLVMFNRLSGGMNSSGMEYGKRWRDHRSLQASVLRPWMTQRYTALRDVETKQLLAELLKTDDFSSCFKRMVASLFMTLAYGKRVQYPDDPEIRGMEELVRVKSEAGEASFRATGQLVEYIPLLQYLPSFLTPWKEMCDRICEQFNKTFVDRLREGINAPAWTWAKEVSKHKVARPMSELEVSYTLGTLYEASLTSQQILRIIVLVAALYPEKAAKAQEELDKVVGADRLPAAADVRNLPYIDAFVKEALRWRPFAPLGAPRESIRDVEYNGYLIPKGATILVNQWALDYNEDVFPEPFSFLPERWIANPDLPFSTFGFGQRGCPGRYFAQDSLFISTARLLWAFNIRTASPVEVEDMLRNPSAGAFLSPIPEFDATFAARDAQRKALIEKEWEIAPKESYAILREVEKELTSEA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of echinulin family alkaloid (PubMed:35843946).  The pathway begins with the biosynthesis of the cyclic dipeptide cyclo-L-Trp-L-Ala (cyclo-TA) by the NRPS criC via condensation of L-alanine and L-tryptophan (PubMed:35843946).  The prenyltransferase criA then catalyzes the first prenylation step, a reverse prenylation reaction at C2, to yield preechinulin (By similarity).  Preechinulin is the substrate of the cytochrome P450 monooxygenase criE that catalyzes the formation of the double bond between C10 and C11 to produce neoechulin A (By similarity).  The unique prenyltransferase criF functions as a competitive enzyme with criE for preechinulin metabolization and uses preechinulin for effective regiospecific prenylations.  Preechinulin is prenylated by criF at C5 or C7.  C7-prenylation leads to accumulation of tardioxopiperazine B without further modification by criF.  In contrast, the C5-prenylated tardioxopiperazine A can be prenylated again by criF, predominantly at C7 to form echinulin or less frequently at C4 to give variecolorin L.  CriF accepts also neoechilunin A to produce varlecolorin G (prenylation at C5) or isoechinulin A (prenylation at C7).  CriF further converts isoechinulin A into dehydroechinulin.  Moreover, a yet unidentified enzyme can also convert neoechilunin A into neoechilunin B by introducing a double bond between positions C14 and C17 and thus provides a further substrate to criF for C5 and C7 prenylation (By similarity).
What are the official names of this protein?
Cytochrome P450 monooxygenase criE, Echinulin biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: FBSB_THEVB
Sequence: MDNVIGLEIIEVVEQAAIASARWMGKGDKNMADQAAVDAMRNRMNQIHMRGRIVIGEGERDEAPMLYIGEEVGICTRPDAAQYCNPEELIEIDIAVDPCEGTNLCAYGQPGSMAVLAISEKGGLFAAPDFYMKKLAAPPAAKGKVDIRNSATENLKILSECLDRAIDELVVVVMKRDRHNDLIQEIRDAGARVQLISDGDVSAALACAFSGTNIHALMGIGAAPEGVISAAAMRALGGHFQGQLVYDPAVVMTKEWANRTREGNLEELKKAGITDPDKVYEAEELASGETVLFAACGITPGMLMKGVRFFKGGARTQSLVISTQSKTARFVDTIHMFDQQLKSLQLY
What is the function of this protein?
Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6-phosphate and sedoheptulose 7-phosphate, respectively.
What are the official names of this protein?
D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase, FBPase class 2/SBPase.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 2 family.
Protein: COQ5_BOVIN
Sequence: MAAPRSWALWSFCGCGWSRAVSGCRLPGLRSSSPRGPLGARLLSQEKEATETHFGFETVSEEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMRPFPGTQLLDVAGGTGDIAFRFLNYVQAQHQRKQKRQLRAQQNLSWEEIARKYQNEEDSLGGSHVMVCDINKEMLKIGKQKARAQGYKAGLAWILGDAEELPFDDNKFDVYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLLSRLYDVYSFQVIPVLGEVIAGDWKSYQYLVESIRQFPSQEEFKEMIEDAGFQKVTYENLTSGIVAIHSGFKLYLR
What is the function of this protein?
Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial, Ubiquinone biosynthesis methyltransferase COQ5.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: LGT_MALP2
Sequence: MTMNNFTTTMQDISTAFTIGSLEIKWYGIFITVGFVLAIILACVKLEKWYKISCNPFYWFVFIGIPVSLLGARIWSFIIGDASKSLATQNFFAAFFNFREGGLAIEGGVLLTVIAALIYFPLVLKKPQYNVKTKIGNEYYVKQVSMWVYADAIVPCILVGQIIGRWGNFFNQEVYGPIATEAELAWLKTLMPGVYNNMFITTTGNLHHPFFLYESFINFWFFLAIYIGGEFIKKRKAGDLAIAYFICYGLLRSCMEPFRYSDYQFATSIVMSVLFALFGIILLVCNHLVFSKHRDFKFWEFIIYKTKKFFKQDIKEFLDSKRNADNLKVQKQINKNITKEPNFYRKPSEIFYYNGY
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOLD1_SYNWW
Sequence: MEIISGSQIAQEIRQKLKEKNEREGISPCLAMILVGGQKEDLHYVGLKEKAATATGGKSRLLHLPEDTSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVDGFSLVNRGRMSGDRPGFISCAALACLEVIERFFPSLAGKKAVLVGDSFDLIIPLATIMIKRACQLSVLPSYEPGLASGADILVVEKGRAGIVQAEGLAPGVLIIDAGFYWGAGGVCGNVDRAALERQGFEARLLPVPGGMGPILIAKLMENLAQAARQKR
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 1.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: HSLU_RALPJ
Sequence: MSETMTPSEIVSELDKHIIGQHKAKKAVAVALRNRWRRQQVGDPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKVRAKAEDAAEDRILDVLIPPPRDIGFAQPEEKDSTARQTFRKKLREGQLDDKEIELEVSAGAPSMDIMGPPGMEDMTEQIRSMFAGLGQGKKNRRKMKVSEAFKLLIDEEAAKLVNEDELKQKAVANVEQNGIVFLDEIDKIASRSEYGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIKTDHILFIASGAFHLSKPSDLIPELQGRFPIRVELDSLSVEDFRAILTQTDASLTKQYQALLKTEGVDLVFAEDGIRRLAEIACSVNEKVENIGARRLYTVMERLLEDLSFHAHKSSGETVTIDAAYVDERLSELSGNEDLSRYVL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADA2C_MOUSE
Sequence: MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWVPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
What is the function of this protein?
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
What are the official names of this protein?
Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CTL2_SALSA
Sequence: MMELEGEKPNYGEPRKYDPTFKGPIYNRGCTDIVCCIFFIICILGYVAVGILAWSQGDPRKVIYPTDSRGQFCGQAGTPLETKPLLFYFNIMKCASPMVLLEFQCPTTQMCVEKCPDKFMTLLKAYANKEDFKYYKNFCKEGLEGLTVTQILSSGLCPAMLTPSKPFTRRCFPALDQKKGGEITVGNNSKFDDGEGNIRDAKDLVAGVKNATVVIEARQVVMKIFEDYTQSWYWILIGLVIAMLISLLFIVLLRFLAGIMVWVMIVMVILVIGYGIFHCSMEYVSLKSEAGSNVTLKDLGFQTDFSVYLHIRQTWLAFIIILAIVEVVIILLLIFLRNRILIAIALIKEASRAIGYVMSALFYPLFTFALLSIVIAYWAVTAVFLSTSNQPIYKVFNDTACDHSRKICEPANFSTSSMKAECPDSKCLFAFYGGETVYHKYLIGLQFYNVFLFFWCANFVTALGQMTLAGAFASYYWALVKPDDMPAFPIFSSLGRSLRYHTGSLAFGSLILSIIQIIRVLLEYIDHKLQGTQNKCTKFLLCCLKCCFWCLEKFIKFINRNAYIMVAIYGKNFCTSAKDAFFLLMRNMIRVAVLDKVTDFLLFLGKLLIVGLVGIFAFFFFSGRVKAFENTAPNLHYYWVPILTVVVGSYLIAHGFFSVYAMCVDTLFLCFLEDLERNDGSAERPYLMSDRLLKVLNKKNKPEPAE
What are the official names of this protein?
Choline transporter-like protein 2, Solute carrier family 44 member 2.
What is the protein family that this protein belongs to?
Belongs to the CTL (choline transporter-like) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HIS7_MAGMM
Sequence: MARIATESRTTGETKIQVTLNLDGSGKAQVDTGVGFLDHMLDQIARHGGMDLEIEACGDQHIDDHHTVEDVGITMGQAFRQAIGDRRGITRFGHAYVPLDEALSRVVVDLSNRPSLSWRVKFPTQKVGNFDTELFKEWFAAFAQQGGITMHVESLYGENSHHIAESCFKALARALRSACAVDATLGGVAPSTKGTLSD
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM_BACCQ
Sequence: MNRKEISKVVDLVRESNPLVHNITNVVVTNFTANGLLALGASPVMAYAKEEVAEMASIAGALVLNMGTLRPEEVEAMLLAGKSANVNNVPVLFDPVGAGATSYRTEVARHIPAEIELAIIRGNAAEIANVINERWEIKGVDAGAGNGNVVSIAKQAADELNTVAVITGKEDVVTDGQRTIVIRNGHPILTKVTGTGCLLTSVIGAFVAVEKDYVKAAVAALTFYGVAAELAAAKTVEKGPGSFQIEFLNQLANTTSGDIEKYGEIEVI
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RDRP_ROTHP
Sequence: MGKYNLVLSEYLSFVYNSQSAVQIPIYYSSNSELEKRCIEFHAKCVDSSKKGLSLKPLFEEYKDVIDNATLLSILSYSYDKYNAVERKLVNYAKGKPLEADLTANELDYENNKITSELFQSAEEYTDSLMDPAILTSLSSNLNAVMFWLERHSNDVADANKIYKRRLDLFTIVASTVNKYGVPRHNEKYRYEYEVMKDKPYYLVTWANSSIEMLMSVFSHEDYLIAKELIILSYSNRSTLAKLVSSPMSILVALIDINGTFITNEELELEFSDKYVKAIVPDQIFDELQEMIDNMRKVGLVDIPKMIQEWLVDCSLEKFTLMSKIYSWSFHVGFRKQKMIDAALDQLKTEYTEDVDGEMYNEYTMLIRDEIVKMLEVPVKHDDHLLRDSELAGLLSMSSASNGESRQLKFGRKTIFSTKKNMHVMDDIAHGRYTPGVIPPVNVDRPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKMLLYAKHTREYAEFYSQSNQLLSYGDVTRFLSSNSMVLYTDVSQWDSSQHNTQPFRKGIIMGLDMLSNMTNDPKVAQTLNLYKQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANSIANLALIKMVLSRIANKYSFITKIIRVDGDDNYAVLQFNTDVTKQMVQDVSNDVRYIYSRMNAKVKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAILYSNYIVNKLRGFETDREFILTKIIQMTSVAITGSLRLFPSERVLTTNSTFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSSQKSGIADEIASSQTFKNYVNKLSDQLLVSKNVIVSKGIAVTEKAKLNSYAPVYLEKRRAQISALLTMLQKPVSFKSNKITINDILRDIKPFFVTSEANLSIQYRKFMPTLPDNVQYVIQCIGSRTYQIEDSGSKSSISKLISKYSVYKPSIEELYKVISLREQEIQLYLVSLGVPPVDAGTYVGSRIYSQDKYKILESYVYNLLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEIINYAIKNGAWISLFCNYPKSEMIKLWKKMWNITALRSPYTSANFFQD
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2.  The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation.  To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates.  VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication.  Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, Protein VP1.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).
Protein: DAPD_BRASB
Sequence: MSLSALESTINSAFDARDGVSTTTKGEIRDAVESALELLDKGEARVAERGTDGTWSVNQWLKKAVLLSFRLNDMSVIPGGPGQASWWDKVPSKFEGWGENRFREAGFRAVPGAIVRRSAFIAKNVVLMPSFVNLGAYVDEATMVDTWSTVGSCAQIGKRVHISGGVGIGGVLEPLQAGPVIIEDDCFIGARSEVAEGVVVRKGAVLAMGVFLGASTKVIDRETGETFVGEVPEYAVVVPGALPGKPMKNGQIGPSTACAVIVKRVDERTRSKTSINELLRD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_POLAQ
Sequence: MARIAGVNIPNHQHTVIGLTAIFGIGTTRANKICQTTGVAIDKKVKDLTDADLEKLRDEVGKFITEGDLRREVTMSIKRLMDLGCYRGVRHRKGLPVRGQRTKTNARTRKGPRKSGVQLKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: LEUD_ARTS2
Sequence: MEKFSTHTGIGVPLRQSNVDTDQIIPAVYLKRITRTGFEDALFAAWRKDPAFILNQEPFNAGSVLVAGPDFGTGSSREHAVWALKDFGFKTVLSSRFADIFRGNSGKQGLLAAEVAQDDIELIWKVLENAPGTEVTVDLVSKTVMCGNVVAPFEIDDYTRWRLLEGLDDIGLTLQHEEDITAYEATRPAFKPKTLPARLS
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: TPS1_DICDI
Sequence: MNILLKDFKYPESWNKSPNQSNQYIDQVFEDTNKIGIYELNNQDHYLYVENLLNVTSYLYPTFDKEQLRLCATYLHWLFLIDDFLEDEYNTMSEKQNDVIKSHAQILLTGQYLNSDVDVKPSEKLTMFLQNTSKDWAIKYNKFDVHNIYMTTLFQWLYSVYPLNKTTESTKPIHMDLYTFIRKVNIGVAGSIIVGLLADKDITDIDISKIWLNPIFTRIMENSTIQIGLVNDCASYDKEYANGGHITNPLYFLQVRDNLTFNETLNFIVNKCNQSIDEIIKDEQLLLKQLKDQGYTENQLNQVNIILNYNHNLIQGNINWSLISKRYNNHDGKPFIFENTKSKYI
What is the function of this protein?
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene (E,E)-alpha-farnesene (PubMed:27790999).  Is also able to convert geranyl diphosphate (GPP) into a mixture of monoterpenes including (Z)-beta-ocimene; (E)-beta-ocimene and allo-ocimene (PubMed:27790999).
What are the official names of this protein?
Terpene synthase 1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: VE1_HPV38
Sequence: MADDKGTDPKEGCSDFIYLEAECSDISDLDNDLETLLEEGAGSDISDLINDEVVEQGNSRELLCQQEREESELQVQYLKRKCFSPKAVQELSPRLQSMNISSEHKSKRRLFVEQDSGLELSLNEAEDSTQELEVPASAPAPAAEGDIGLGTVRDLLRSSNSRATLLSKFKDSFGVSFTELTRQYKSNKTCCHHWVLAVYAAKDDLIDASKQLLQQHCFYIWLQSFCPMSLYLCCFNVGKSRDTVVRLIATLLQVHENHILSEPPKNRSIPAALFWYKGSLNSNVFCFGEAPDWILSQTMIQHQTADTLQFDLSRMIQWAYDNDHIDESIIAYQYAKLADIDSNAKAFLAHNSQVKYVKECALMVRYYKRGEMKEMSISAWIHHCISKVEGEGNWQHIVRFIRYQNLNFIMFLDKFRTFLKNLPKKNCLLIYGPPDTGKSMFAMSLIKLLKGSVVSFANSKSQFWLQPLADGKIGLLDDATDVCWQYIDSFLRNGLDGNLVSLDIKHKAPCQMKFPPLIITSNINLLKEERYRFLHSRVTQIDFPNKFPFDSDNKPLFELTDQSWASFFKRLWTQLELSDQEDEGDNGNSQRTFHCTAREVNGHI
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: GUAA_TROW8
Sequence: MRPVLVVDFGSQYSQLVVRAIRECGYYAEFASPSISAAECLALSPIAIFLSGGPASAYKDNAPKLDEEIFNCGIPIFGICYGFQLLAQAFGGSVKKANAPEYGPADITIVNKAFFSGQPDRQTVWMSHGDSVIRAPKNFCILSTSQDAVLSFCNRDRTIAGVQWHPEVKHSRFGKHTIKAFLSSFAAPNWDPEQTICGTVDSIRKTVGCKRVLCALSGGVDSVVAATLTHRAIGDRLRCVFVDHGLLRLNEREQVEEYCSSLGLNVSTYDASDCFLSALSGIRDSEQKRKVIGREFIACFSKLQERFDIKPHFLLQGTLYPDLVESGATPGGATIKSHHNVGGLSDNLGFELLEPLKYLFKDEVRKIGLQLGIPKHIVHRQPFPGPGLAIRIIGEVTNKKLSILRAADAIVRHELRDWTDIWQCPVILLSDVQSVGVRGDSRSCGFPIVIRPVSSDDAMTADWYRLPYDVLARISGRITNEIPEIVRVVLDITPKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.