PharMolix/UniProtQA huggingface dataset:
Protein: ROK1_LODEL
Sequence: MDIFRILSRGASINKKKDQTSTNSSLIKLSLPSTANKHEHLLDEVERETDFFRTKSHRKLDEPSSKILKSKNKDEERESVAEIVPPLELESEEDARVFRNLHKSKVTGDDIPIPIGSFQDMIGRFKIDKRVLSNLLDAEFVEPTPIQCEAIPITLANRDLIACAPTGSGKTLAFLIPLLQQLVSQNVLKNHGIRGLIISPTNELAVQIFQQLEIISKGKGLNIAILSKQLAGKISNDVVKASKYDILVSTPLRLIDVVKLGKVDLSKVTQLVIDEADKLFDHGFAEQTDELLSHCTNVKIRKSMFSATIPSGVEEMAHSIMKDPIRVIIGHKEAASNTIEQKLVFTGNEEGKLLAIRQMIQNGEFKPPIIIFLQSITRAKALFHELVYDKLNVDVIHAERTPKQRDEVIKRFKNGDIWVLITTDVLARGVDFKGVNMVINYDVPQSAQAYVHRIGRTGRGGRSGKAVTFFTKEDDKAVKPIINVMKQSGCTDGLSDWMEDLGKLSKREKRAVKTHEIERKKISTVPSVIKQKRKQRQNMIEASKRRKQAESEQ
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase ROK1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: THAA_DANRE
Sequence: MENTEQEHNLPEGDETQWPNGVKRKRKNSQCSMNSTSDKSISVPGYVPSYLEKDEPCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYDSCCIIDKITRNQCQLCRFRKCISVGMAMDLVLDDSKRVAKRRLIEENREKRKKEEIVKTLHNRPEPTVSEWELIRMVTEAHRHTNAQGPHWKQKRKFLPEDIGQSPAPTSDNDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVSREQLKNGGLGVVSDAIFDLGKSLSQFNLDDSEVALLQAVLLMSSDRSGLTCVEKIEKCQEMYLLAFEHYINHRKHNISHFWPKLLMKVTNLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEGSTGVAAQEDGSCLR
What is the function of this protein?
High affinity receptor for triiodothyronine (By similarity).  In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor.  Whereas in the presence of thyroid hormone, can act as an activator of transcription.  In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development.
What are the official names of this protein?
Thyroid hormone receptor alpha-A, zTRalpha-A, Nuclear receptor subfamily 1 group A member 1-A, Thyroid hormone receptor alpha-1, TRalpha-1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HGD_CUPPJ
Sequence: MNLTHTQLAEHGYMSGFANEFATEALPGALPVGQNSPQRAPYGLYAEQLSGTAFTAPRAHNRRSWLYRIRPGAVHKPFTLVEQSRFLSRFDEVPPSPNQMRWSPPAMPTTPTDFIDGIVTMAGNGGPDAMTGCGIHLYLANQSMQDRFFYNADGEMLIVPQQGRVRFVTEMGRLDVEPQEIVVIPRGVRFRVELPDGEARGYICENYGALFKLPDLGVIGSNGLANPRDFMTPVAAYEDREGDFELVAKFQGNLWRADIGHSPLDVVAWHGNFAPYKYDLRRFNTIGSISFDHPDPSIFLVLQSPSDTPGVDTIDFVIFGPRWLAMENSFRPPWFHRNIASEFMGLITGVYDAKADGFAPGGASLHNCMSGHGPDADTFAKATSADTSTPHHITDTMAFMFETPGVIRPTPYAARSASLQQDYYTCWQGLKKHFNPNVR
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: YACG_SHESW
Sequence: MPLTVKCPICKTPVEWAPQSEFKPFCSERCKLIDLADWASEKHAIPVKSEFDLDALDEFDLDEDAFFKE
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: HIS6_HERA2
Sequence: MLTRRIIPCLDVKAGRVVKGISFLNHRDAGDPVQLAAFYNESGADELVFYDITASSDERNIMVEVVENVARQVFIPLTVGGGIRTVDDMYRMLRAGADKVSINTAAVLNPQLIEDGAKRFGSQCIVLSMDARRINEPGQPSQWNVFTHTGRDPRPTGLDAIEWAKRVVDLGAGELVINSMDADGTGAGYDNELLSAISQQVGVPVIASGGAGKPEHLLAALHEGKADAVLAASIFHFGTYTVEAVKEYLANQGIPMRRTPRPV
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_BURP1
Sequence: MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLFGEEVHLLEPQTYMNRSGQAVVALAHFFKILPTEILVAHDELDLPPGAAKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLKPPRKDEQDLIDAAIERALAVMPTAIKGETERAMMQLHRNGA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTND3_ARATH
Sequence: MGEVVKDGREEVIQAWYMDDSEEDQRLPHHKDPKEFLSLDKLAELGVLSWRLDADNYETDEDLKKIRESRGYSYMDFCEVCPEKLPNYEVKVKSFFEEHLHTDEEIRYCVAGSGYFDVRDRNEAWIRVWVKKGGMIVLPAGIYHRFTVDSDNYIKAMRLFVGEPVWTPYNRPHDHLPARKEYIDNFVKVNEGGVIDASA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase 3, Acireductone dioxygenase (Fe(2+)-requiring) 3, ARD' 3, Fe-ARD 3, Acireductone dioxygenase (Ni(2+)-requiring) 3, ARD 3, Ni-ARD 3.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LGT_CORGL
Sequence: MTLATIPSPPQGVWYLGPIPIRAYAMCIIAGIIVAIWLTRKRYAARGGNPEIVLDAAIVAVPAGIIGGRIYHVITDNQKYFCDTCNPVDAFKITNGGLGIWGAVILGGLAVAVFFRYKKLPLAPFADAVAPAVILAQGIGRLGNWFNQELYGAETTVPWALEIYYRVDENGKFAPVTGTSTGEVMATVHPTFLYELLWNLLIFALLMWADKRFKLGHGRVFALYVAGYTLGRFWIEQMRVDEATLIGGIRINTIVSAVVFAGAIIVFFLLKKGRETPEEVDPTFAASVAADAVASPDGKPLPKAGEGIDGETPSTR
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRMB_YERPS
Sequence: MINDVISPEFDENGRALRRIRSFVRRQGRLTKGQQLALDSYWPVMGVEYQAAPVDLNTLFGREAPVVLEIGFGMGTSLVTMAANNPQQNFLGIEVHSPGVGACLSSAHDAGLSNLRIMCHDAVEVLENMIPEASLDMVQLFFPDPWHKARHNKRRIVQTPFVELVKSKLKVGGVFHMATDWQPYAEHMLEVMSGVSGYLNLSEQNDYVPRPDSRPLTKFELRGQRLGHGVWDLMFERKE
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: F217A_RAT
Sequence: MGRKSNESCSANPHSSSISQENLSQWNLDAEDLFDENESFLSEKDGVAGGKTNKNHLESPAEQLVLQLTVSEHAHSRSQNNNQGVFQLWSSPVNKGSIIDKRNSSVEENVTDESDLSESEKMNDSLLSYFKKMDLNLKPETIEHVERAFTEEANQVSVYADFLPAPFNTMDLHRFAFSKCESWKTTVDPPESSIERLIMRLLELERLQHMTIQRERPKLQSTFCSSMFSMAERPSSSKAITLKARPPKIPETPTLQTSSVDKNRDKRKNNSGSGKPEQNVPKWSLSTAGKSKSNSRSLLKCSSTSKQCAMAHDDVKNPKNSILNPCQDPPPKPTTTTQAIQPMIKVVSTRCLPPRSPMPVSPIPLSFPENPREEVKVPRTKKKCHRKSILQNRPFHVQKRNCLSPSLIARGKCSPTDQK
What are the official names of this protein?
Protein FAM217A.
What is the protein family that this protein belongs to?
Belongs to the FAM217 family.
Protein: NHR69_CAEEL
Sequence: MVEEICHICNDKSTGKHYGAISCDGCKGFFRRSIRKRYHYQCRFEQNCDVTKNKRNACRACRLQKCVKAGMKSNAIQNERDAIGKRKKTTGAEKEDLIDQLVAAETLCQQLRSSVIKNTSSLAPYDCGKVKWNYEDARAATLDDIGKSIHQQLVLFIEWAKSLPQFSFLAQADQAALLKGGAASIIVLGVAYRSICLTVENTICLANDTLLPKEHATQVGDINCVVGRIIDEIVNPMRRLNMDLIEYVALKAILFFNPVVREINDQSPVENARYAFLRSLQRRCTDKALENMEDESMDCRSGKLLLLLPSLQAIAQQLVEDVQLARLFGLVNVDSLMEELILNDMKPSDPQILQTSLASPVNSSVKAEVELEE
What is the function of this protein?
Orphan nuclear receptor which, in cooperation with R-SMAD daf-8, modulates the Insulin/IGF-1-like signaling (IIS) pathway, perhaps by regulating expression of the potassium channel exp-2, which in turn modulates the secretion of insulin-like peptide daf-28.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-69.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS5_XANOR
Sequence: MAEERAPRGRDRDRNREEKVDDGMIEKLVAVNRVSKTVKGGRQFTFTALTVVGDGLGKVGFGYGKAREVPVAIQKSMEQARKNLATVDLNNGTLWHAVKSGHGAARVYMQPASEGTGVIAGGAMRAVLEAVGVKNVLAKAVGSRNPINLVRATLKGLSEVQSPARVAAKRGKKVEELNHG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: LIPB_ANAMM
Sequence: MSLLGFPVEWRVSDGMVDYKAALDFMTSRVDGILEGRESEMVWLLEHPSVYTAGVSAKDGELLSENKFQVVRTTRGGKYSYHGPGQRVVYVMLHLGRRDKRDVRLYVRNLGLWVVGTLAEFGIDSHFDDDNTGVWVQYSRQAKKIAAFGIAIRRWVTYHGFSVNISTDLGCYSGIVPCGIAGSHVTSLQDLGVTVPFEEFDAVLQQKFDTIFLQ
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_VIBCM
Sequence: MSDKIRTQLGRVVSDKMDKSIVVAIERMVKHPIYGKFVKRTTKVHAHDENNECGIGDTVEIRECRPLSKTKSWTLVKIVEKAKM
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: WECG_CITK8
Sequence: MTDNTTAPLYSLRGLQLIGWRDMQHALNYLFADGQMKQGTLVAINAEKMLTAEDDPEVRALIDAAEFKYADGISVVRSVRKKFPQAQVSRVAGADLWEELMARAGKEGTPVFLVGGKPEVLAQTEAKLRAQWNVNIVGSQDGYFKPEQRQALFERIHASGAKIVTVAMGSPKQEILMRDCRVIHPQALYMGVGGTYDVFTGHVKRAPKMWQTLGLEWLYRLLSQPSRITRQLRLLRYLRWHYTGNL
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: RNE_SYNY3
Sequence: MPKQIVIAEKHQVAAVFWKDQIQELVVSTGSQQVGDIYLGLVDNILPSIDAAFINIGDTEKNGFIHVSDLGPVRLRRTAGSISELLSPQQRVLVQVMKEPTGNKGPRLTGNISMPGRYMVLMPYGRGVNLSRRINREEERSRLRALAVLIKPPGMGLLVRTEAEDVPEDAIIEDLENLQKQWELVQQQAMTRSAPMLLDRDDDFIKRVLRDMYSSEVNRIVVDTPAGMKRIKQQLMNWDQGRLPEGVLIDCHRESLSILEYFRVNATIREALKPRVDLPSGGYIIIEPTEALTVIDVNSGSFTHSANSRETVLWTNYEAATEIARQLKLRNIGGVIIIDFIDMDSHKDQLQLLEHFNRCLETDKARPQIAQLTELGLVELTRKRQGQNLYELFGQPCPECGGLGHLVELPGEKGFVSLSPTAVNSSIPPRLVEKPILSPPVAKVNDLPKKEEAKISSPLDLLFHPNYQEQGDRDSNRRRRRRRGSEFSEKENIKSVGISRSKGPSPSPTKEKVTGTAPPRRERPSRRVEKTLVPVDVAMTTLEQDIYARMGISPLIKTEYADQDPRSFMVSVVTAGAALEGNTNGSGSLVNAVITTVDNGDNGDNVPSDGLTIVSEVTAPTPVIEQPREETVEPEQVVLPQLDDETPAAPVAEESAPIETKKRPGRRRRRSSAE
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Endogenous RNase E is required for correct processing of pre-crRNA for the CRISPR3 subtype III-B system in this genome (genes sll7080 to sll7095).  This CRISPR3 system does not include a cas6 gene, which is the usual RNase involved in crRNA maturation.
What are the official names of this protein?
Ribonuclease E, RNase E, SynRne, Ribonuclease E/G.
What is the protein family that this protein belongs to?
Belongs to the RNase E/G family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Subcellular locations are shown upon expression in E.coli of the N-terminal domain (residues 1-396) (PubMed:22509045). Some of the protein cosediments with polysomes (PubMed:27215789).
Protein: ACP_BURO0
Sequence: MDNIEQRVKKIVAEQLGVAEAEIKNEASFVNDLGADSLDTVELVMALEDEFGMEIPDEEAEKITTVQQAIDYARANVKA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
Protein: SYS_AERHH
Sequence: MLDPKYLRSDIAEAAARLATRGYVLDVAAVNALEEKRKDLQSRTQELQAERNARSKSIGEAARRGEDVAPLKAEVTKINEELETSKVELDALLAELKVIADAIPNLPSDTTPVGRDENDNVEVRRWGTPREFSFPVRDHIDLGEAAKGVDFKNGVKLSGSRFVVMKGQIARLHRALAQFMLDLHTLQHGYTECYVPYLVNPDSLYGTGQLPKFSQDLFNTGIDGEGEEEGKVRKFSLIPTSEVPLTNMARDEIFDEQELPIKMTAHSPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQLVHPEKSWEALEEMAGHAEKVLQLLELPYRVMALSTGDMGFCAAKTYDLEVWLPAQNTYREISSVSNCTDFQARRMQARVRIDGKPQLLHTLNGSGLAVGRTLVAVIENYQQEDGRIAIPAALQSYMGGLTHIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLTE_BUCBP
Sequence: MKKVILFTYVIIFLVFLSGYSVVTKNIVHNIKNNYKNNVCSMKVMHLWFKIINLFSKKYNVDKKLITAIICVESSGNTHAVSISKAIGLMQIKPFSAGREVYRFRGLLNQPSDVDLYDPKINIDIGTSYINILRNKILSGIKNSEILLYATIISYAHGASKLLKSFSYNKTLAIKKINKMKIKEFLDYIHNKYSEKKAWDYLSKVMYVYHLV
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity).
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase E, Murein hydrolase E.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
Protein: TM86B_MOUSE
Sequence: MDARKEGLPLETLFSDQYPQVRRWLAPFILACSLYFLLWIPVDQPSWVSALIKCQPILCLVVFLWAVAPGGSSTWLLQGALVCSAVGDACLIWPEAFFYGTAAFSVAHLFYLGAFGLTPLQPGLLLCTTLASLTYYSFLLLHLEQGMVLPVMAYGLILNSMLWRSLVWGGSASWGAVLFTFSDGVLAWDTFVYSLPFARLVTMSTYYAAQLLLILSALRNPGLKTH
What is the function of this protein?
Enzyme catalyzing the degradation of lysoplasmalogen.  Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens.  May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.
What are the official names of this protein?
Lysoplasmalogenase, Transmembrane protein 86B.
What is the protein family that this protein belongs to?
Belongs to the TMEM86 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cytoplasm.
Protein: Y05L_BPT4
Sequence: MISIEQADKIKELVALIRKADEERINFALSGIEEFEAKVNNAVEALDMFLDEIIDHNTRV
What are the official names of this protein?
Uncharacterized 6.8 kDa protein in mobD-ri intergenic region.
Protein: TPIS_MYCMS
Sequence: MKKKVIFGNWKMNGTNESLTDFLNQVDNKIDSSKIIAGLAVPYVMLQTGLKLAKNVKIAAQNVHYKDKGAYTGEISTTMLKEVGVEYVIIGHSERREMFNETDLDVNKKAKVLLENNITPIICCGETLQTKESGKTIEFVNNQINIMFEGIKKEDAIKAIIAYEPIWAIGTGKTATSSDAEEVCKQIRNNLSKIYDKNTAEQIIIQYGGSVKPSNIQEYLKMPNIDGALVGGASLLASDYLGLVNYNE
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDM34_MAGO7
Sequence: MAFNFNWSPLTADASFYKRARDLLTTALNKSPKPPIIVDDILVTEFNLGSVPPELEILEIGDLAEDRFRGIFKMTYSGDAFLTLKTRVQANPLNTYLYSKPSFTSPEPLAAASGLTIPLQITLSEIKLSAFIILVFSKQKGLTLVFRNDPLESLKVSSTFDSIQFVRDYLQRTIEGKLRNLMMDELPAIIHKLSLQLWCPEQMSKEDHEKTNEMDEQAVNPFASPPLDAVDAHGNLLDPIDISSIAVNGGAELQSLFSQKNLFRLGNLVNTQLTSSLFTPSVPEVIFRAKAGPVDKPEASSTTPLTTPSLVKSHSFHGTSTVYTFSDTSSQNNGQLPSRPSLVSLGSATTGLGLAASRNAKPYANRKKKTRVVNLRRKTDTAASSEMGDTMSDSASVQASESITMSDSIPEDPEEQPELTMSGSSRVRFGLGGERSALPQRPALRRDLFNPDEATASAEISQPQVARSTPEKETAAPVRTSENDKRSDSKRRGPRSETPSVILEQAWIMKMAGEIAKRVYDEKQRNPSFWDEREDSPPPAYEAQPTTAAS
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: MTR1A_RAT
Sequence: CYICHSLKYDRIYSNKNSLCYVFLIWTLTLIAIMPNLQTGTLQYDPRIYSCTFTQSVSSAYTIALVVFHFVVPMIIVTFCYLRIWILVLQVRRRVKPDSKPKLKPQDFRNFVTMFVVFVLFALCWAPLNFIGLIVASDPATMAPRIPEWLFVASYY
What is the function of this protein?
High affinity receptor for melatonin.  Likely to mediate the reproductive and circadian actions of melatonin.  The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
What are the official names of this protein?
Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2795_SINFN
Sequence: MAGHSQFKNIMHRKGRQDAVRSKMFSKLAREITVAAKSGMPDPAMNPRLRLAIQNAKAQSMPKDNIERAVKKAAGGDAENYEEVRYEGYGPGGVAVIVEALTDNRNRTASNVRSMFTKAGGALGETGSVSFSFDRVGEITYTLSAGDADKVMEAAIESGADDVTTDEDGHTILCGFEEIGDVSKALEGVLGEAETVKAIWKPQNTVPVDEEKAQSLMKLIDNLEDDDDVQNVYSNFEVSEEVLAKLSA
What are the official names of this protein?
Probable transcriptional regulatory protein NGR_c27950.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEFB1_PREME
Sequence: MRTSYLLLFTLCLLMSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTKIQGTCYHGKAKCCK
What is the function of this protein?
Has bactericidal activity.  May act as a ligand for C-C chemokine receptor CCR6.  Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner.  Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
What are the official names of this protein?
Beta-defensin 1, BD-1, Defensin, beta 1.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles.
Protein: DER_SALTI
Sequence: MVPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAEVEGREFICIDTGGIDGTEDGVETRMAEQSLLAIEEADVVLFMVDARAGLMPADEAIAKHLRSREKPTFLVANKTDGLDPDQAVVDFYSLGLGEIYPIAASHGRGVLSLLEHVLLPWMDDVAPQEEVDEDAEYWAQFEAEQNGEEAPEDDFDPQSLPIKLAIVGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMERDEREYVLIDTAGVRKRGKITDAVEKFSVIKTLQAIEDANVVLLVIDAREGISDQDLSLLGFILNSGRSLVIVVNKWDGLSQEVKEQVKETLDFRLGFIDFARVHFISALHGSGVGNLFESVREAYDSSTRRVSTAMLTRIMTMAVEDHQPPLVRGRRVKLKYAHTGGYNPPIVVIHGNQVKDLPDSYKRYLMNYFRKSLEVMGTPIRIQFKEGENPYANKRNTLTPTQMRKRKRLMKHIKKSK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: EFTU_BORDL
Sequence: MAKEIFQRTKPHMNVGTIGHVDHGKTTLTAAISIYCSKVNKDAKALKYEDIDNAPEEKARGITINARHIEYETANRHYAHVDCPGHADYIKNMITGAAQMDAAILLVAADSGAEPQTKEHLLLAQRMGIKKIIVFLNKLDLADPELVELVEVEVLELVEKYGFPSDTPIVKGSAFGAMSNPDDPEATKCIKELLETMDNYFDLPERDIDKPFLLAIEDVFSISGRGTVATGRIERGVIKVGQEVEIVGIRETRKTTVTGVEMFQKILEQGEAGDNVGLLLRGVDKKDIERGQVIAALGTITPHKKFKASIYCLTKEEGGRHKPFFSGYRPQFFFRTTDVTGMVSLEGKEMVMPGDNVDIVVELISSIAMDKNVEFAVREGGRTVASGRILEILE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOH_WIGBR
Sequence: MKPFFWRIIGSGSVNLVFIHGWGLNSCIWNNIIIILSNYFKLHLVDLPGYGKNILYKEYSFSKITEIIACKSPKKSILIGWSLGGLIATNISIVYPEKFKGLIIVSSSPCFCEKKDWPGIKKEILNNFSFQLKNDFHNTVKKFFNIQFLGTKKNNNEIKKLKNIFFRQKEPSYKTLSSGLKILKNIDIRNYLKYIKIPTLRIYGNLDVIVPVKIIPIIKKLQNFNINKNIIIPSASHAPFLSHPFLFCKIIKYFIKKFN
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.