PharMolix/UniProtQA huggingface dataset:
Protein: SICP_SALTY
Sequence: MGLPLTFDDNNQCLLLLDSDIFTSIEAKDDIWLLNGMIIPLSPVCGDSIWRQIMVINGELAANNEGTLAYIDAAETLLLIHAITDLTNTYHIISQLESFVNQQEALKNILQEYAKV
What is the function of this protein?
Molecular chaperone required for SptP stabilization and secretion.
What are the official names of this protein?
Chaperone protein SicP.
What is the protein family that this protein belongs to?
Belongs to the SicP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_LISW6
Sequence: MSIQIFNTLTREKEPFKPLKDGEVKMYVCGPTVYNYIHIGNARPIIVFDTVRRYFTYRGYDVKFVSNFTDVDDKLIRAANELKLTVPEVADRFIGAYFDDVDQLNVAKASVNPRVTENMDEIIQLISTLIEKGYAYESAGDVYFRTKKFKDYGKLSGQELSELQHGARVEYNERKQDELDFTLWKAAKPDEIFWESPFGNGRPGWHIECSALAKKYLGDTIDIHAGGQDLVFPHHEDEIAQSEAATGKTFANYWMHNAFLNIDGEKMSKSLGNFITLHDVLKDNDPNVIRFFMLSVHYRKPITLNDAILEDAKNGLERLMIAYQNIDHRIQTDDGEYVEEAHEDEWLEQLTELKQAFEDDMDDDFNTANAITTFHELAKRANIYLAKETVSINVLREFLSMMRLFAEVLGLKLENTQTDSLDDSEVEALIEERLQARNERNFARADEIRDILKEKNIILEDTAQGTRFRRG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSC_SALPB
Sequence: MKRIAFVFSTAPHGSASGREGLDALLATSALTEALGVFFISDGVFQLLPGQKPDAVLARDYIATFKLFDLYDIDQCWICAASLRERGLENVNFVVDATPLEPVALRRELGNYDVILRF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSYL4_HUMAN
Sequence: MSGLDGGNKLPLAQTGGLAAPDHASGDPDRDQCQGLREETEATQVMANTGGGSLETVAEGGASQDPVDCGPALRVPVAGSRGGAATKAGQEDAPPSTKGLEAASAAEAADSSQKNGCQLGEPRGPAGQKALEACGAGGLGSQMIPGKKAKEVTTKKRAISAAVEKEGEAGAAMEEKKVVQKEKKVAGGVKEETRPRAPKINNCMDSLEAIDQELSNVNAQADRAFLQLERKFGRMRRLHMQRRSFIIQNIPGFWVTAFRNHPQLSPMISGQDEDMLRYMINLEVEELKHPRAGCKFKFIFQGNPYFRNEGLVKEYERRSSGRVVSLSTPIRWHRGQDPQAHIHRNREGNTIPSFFNWFSDHSLLEFDRIAEIIKGELWPNPLQYYLMGEGPRRGIRGPPRQPVESARSFRFQSG
What are the official names of this protein?
Testis-specific Y-encoded-like protein 4, TSPY-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
Protein: RN146_HUMAN
Sequence: MMAGCGEIDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVSAQSGASVQPLVSSVRPLTSVDGQLTSPATPSPDASTSLEDSFAHLQLSGDNTAERSHRGEGEEDHESPSSGRVPAPDTSIEETESDASSDSEDVSAVVAQHSLTQQRLLVSNANQTVPDRSDRSGTDRSVAGGGTVSVSVRSRRPDGQCTVTEV
What is the function of this protein?
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation (PubMed:21478859, PubMed:21799911, PubMed:22267412).  May regulate many important biological processes, such as cell survival and DNA damage response (PubMed:21825151, PubMed:22267412).  Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex (PubMed:21478859, PubMed:21799911).  Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2 (PubMed:21799911).  Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation (PubMed:21799911).  Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48' (PubMed:21799911).  May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location (PubMed:21799911).  Neuroprotective protein (PubMed:21602803).  Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity).  Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity).  Does not affect PARP1 activation (By similarity).  Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity).  Promotes cell survival after gamma-irradiation (PubMed:21825151).  Facilitates DNA repair (PubMed:21825151).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF146, Dactylidin, Iduna, RING finger protein 146, RING-type E3 ubiquitin transferase RNF146.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding.
Protein: EFTS_RHIME
Sequence: MTVTAAMVKELREKTGAGMMDCKKALAETNGDMEAAIDWLRAKGIAKADKKSGRTAAEGLIGIASSGTKAVVVEINSETDFVARNDAFQELVRGVANVALGTDGSVAAVSKATYPATGKSVEDTIKDAIATIGENMTLRRSALLEVEDGVVATYVHNAAGEGIGKLGVLVALKSTGDKEALNAIGRQVAMHVAATNPLAVRSSEIDPAVAERERNVFIEQSRASGKPDNIIEKMVDGRMRKFFEEVALLSQAFVMNPDQTVEAAIKEAEKSVGAPIEVAGIARLLLGEGVEKEESDFAAEVAAAAKG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESXB_THECD
Sequence: MAPQSAVDRAAMAQAAQDIEQSANAIRGMQNQLASAKDQLRSHWEGDASMAFEAVFNRFNEDFSRVLKALDGMHESLVQTRITYEAREEAAQQSVNRVQALLNG
What is the function of this protein?
May help regulate assembly and function of the type VII secretion system (T7SS).  Binds to EccC and induces its multimerization (PubMed:25865481).  May serve as a chaperone for EsxA (By similarity).
What are the official names of this protein?
ESAT-6-like protein.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. CFP-10 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX / type VII secretion system (T7SS).
Protein: RL31_MESFL
Sequence: MPKKDIQPKYFEEAKFICTTCANEFICGTTKREEMRIDVCSNCHPFFSGAQNFANTTGRVEQFKSKFARKEAINATAQKNSEDQKSKNKENK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: LEPA_CHLL3
Sequence: MAPSSPEVSRIRNFCIIAHIDHGKSTLADRLLEMTHTLDRTQMDSAQVLDDMDLERERGITIKSHAVQMKYCSVAGDDYTLNLIDTPGHVDFSYEVSRSLAACEGALLVVDATQGVEAQTIANLYLAIEAGLEIIPVINKIDLPSSDVEGVARQIIDLIGIEREEILQVSAKAGLGVAELMEAIIARVPAPADNRKQPLRALIFDSVFDPYRGAVVYLRIVDGVLRRGEKVRFFANDKIFLADEIGTMALKRQPKEVLEAGDVGYLICSIKDVKDAKVGDTVTHAEVPAEKRLAGYKDVKPMVFSGLYPVNSNEFEDLRESLEKLSLNDASLVYTPETSVALGFGFRCGFLGLLHMEIIQERLEREYDMNIITTVPNVEYRVIMTNGETVIVDNPSKMPDTTRIAHVEEPYVSMQIITLADYIGNIMKLGMERRGEYRNTDYLDTQRVNMHFEFPLAEIVFDFHDRLKSISKGYASMDYEYIGYRESDLVKLDVLLNAEPVDALSIIVHRSKAYDWGRKLCGKLKGIIPKQMYEVAIQAAIGSRIISRETISAMRKNVLAKCYGGDISRKRKLLEKQKEGKKRMKQVGRVEVPQEAFLAILNIDE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: COAE_CORGT
Sequence: MLKIGLTGGIGSGKSTVADLLSSEGFLIIDADQIAREIVEPGQPALAELVEAFGPEIIKEDGSLDRQGLAAKAFVDAEHTALLNSITHPRIAEETARRFAEAEANGTKVAIYDMPLLVDKGLDRGMDLVLVVDVNVEERVRRLVEKRGLGEKDVRRRIDSQVPDEVRLKAADVVIDNNGSLEDLKANMKNVIAEI
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKT2F_HETCR
Sequence: RGICSEPKVVGPCKAGLRRFYYDSETGECKPFIYGGCKGNKNNFETLHACRGICRA
What is the function of this protein?
Dual-function toxin that inhibits both serine proteases and voltage-gated potassium channels (PubMed:26404319, PubMed:33158163).  Has potent activity on both trypsin (Ki=28 nM) and chymotrypsin (Kd=1. 8 nM) (PubMed:26404319).  Shows inhibitory activity against 4 of the 7 potassium channels tested (rKv1. 1/KCNA1; IC(50)=142. 6 nM, hKv1. 3/KCNA3; IC(50)=40. 7 nM, rKv1. 6/KCNA6; IC(50)=154. 9 nM and drosophila Shaker; IC(50)=433. 1 nM) (PubMed:33158163).  Has an anti-inflammatory effect in LPS-activated macrophages in vitro, specifically reducing release of TNF and IL6 but not nitric oxide and reducing expression of IL1B precursor (PubMed:26404319).  In contrast to some paralogs, this protein decreases reactive oxygen species (ROS) level in the oxidative stress agent 6-hydroxydopamine (6-OHDA)-induced neurotoxicity model, but does not show cytoprotective activity on neuroblastoma cells (PubMed:33802055).  This protein also shows a weak free-radical scavenging activity (PubMed:33802055).  In vivo, when tested in a mice model of acute local inflammation, it reduces paw edema during 24 hours.  In addition, it also reduces the synthesis of TNF in this model (PubMed:33158163).
What are the official names of this protein?
PI-stichotoxin-Hcr2f, PI-SHTX-Hcr2f, Kunitz-type serine protease inhibitor HCRG1.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RBFA_PSEPK
Sequence: MAKEYSRTQRIGDQMQRELAELIRREVKDPRVGLVTITAVDVSRDLGHAKVFITVMGEETPDAVQQSLKALNSAASFLRLHLGRSMQLRSVPQLHFHFDESVSRGVHLSALIERAVAEDRLHKDADESDTKE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSL1_CAEEL
Sequence: MPATPVRASSTRISRRTSSRSVADDQPSTSSAVAPPPSPIAIETDEDAVVEEEKKKKKTSDDLEIITPRTPVDRRIPYICSILLTENRSIRDKLVLSSGPVRQEDHEEQIARAQRIQPVVDQIQRVEQIILNGSVEDILKDPRFAVMADLTKEPPPTPAPPPPIQKTMQPIEVKIEDSEGSNTAQPSVLPSCGGGETNVERAAKREAHVLARIAELRKNGLWSNSRLPKCVEPERNKTHWDYLLEEVKWMAVDFRTETNTKRKIAKVIAHAIAKQHRDKQIEIERAAEREIKEKRKMCAGIAKMVRDFWSSTDKVVDIRAKEVLESRLRKARNKHLMFVIGQVDEMSNIVQEGLVSSSKSPSIASDRDDKDEEFKAPGSDSESDDEQTIANAEKSQKKEDVRQEVDALQNEATVDMDDFLYTLPPEYLKAYGLTQEDLEEMKREKLEEQKARKEACGDNEEKMEIDESPSSDAQKPSTSSSDLTAEQLQDPTAEDGNGDGHGVLENVDYVKLNSQDSDERQQELANIAEEALKFQPKGYTLETTQVKTPVPFLIRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCSLSKRQRYLYDDFMSRRSTKENLKSGNMMSVLNIVMQLRKCCNHPNLFEPRPVVAPFVVEKLQLDVPARLFEISQQDPSSSSASQIPEIFNLSKIGYQSSVRSAKPLIEELEAMSTYPEPRAPEVGGFRFNRTAFVAKNPHTEESEDEGVMRSRVLPKPINGTAQPLQNGNSIPQNAPNRPQTSCIRSKTVVNTVPLTISTDRSGFHFNMANVGRGVVRLDDSARMSPPLKRQKLTGTATNWSDYVPRHVVEKMEESRKNQLEIVRRRFEMIRAPIIPLEMVALVREEIIAEFPRLAVEEDEVVQERLLEYCELLVQRFGMYVEPVLTDAWQCRPSSSGLPSYIRNNLSNIELNSRSLLLNTSTNFDTRMSISRALQFPELRLIEYDCGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADPKVFCFILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERTIEENILRKATQKRRLGELAIDEAGFTPEFFKQSDSIRDLFDGENVEVTAVADVATTMSEKEMEVAMAKCEDEADVNAAKIAVAEANVDNAEFDEKSLPPMSNLQGDEEADEKYMELIQQLKPIERYAINFLETQYKPEFEEECKEAEALIDQKREEWDKNLNDTAVIDLDDSDSLLLNDPSTSADFYQSSSLLDEIKFYDELDDIMPIWLPPSPPDSDADFDLRMEDDCLDLMYEIEQMNEARLPQVCHEMRRPLAEKQQKQNTLNAFNDILSAKEKESVYDAVNKCLQMPQSEAITAESAASPAYTEHSSFSMDDTSQDAKIEPSLTENQQPTTTATTTTTVPQQQQQQQQQKSSKKKRNDNRTAQNRTAENGVKRATTPPPSWREEPDYDGAEWNIVEDYALLQAVQVEFANAHLVEKSANEGMVLNWEFVSNAVNKQTRFFRSARQCSIRYQMFVRPKELGQLVASDPISKKTMKVDLSHTELSHLRKGRMTTESQYAHDYGILTDKKHVNRFKSVRVAATRRPVQFWRGPKALESRNLQSLNGGMPPRHESRLAEFDVKTNIRLDAEDIVTMSDESIVAYEASKKKLLASRQTKPSPRQDVRFHTLVLRPYTVPVTTEYSAAPSRREMRIAVPPLQPSALSTISSVAAAATSGPLPSIQHLQSSSTGLGSQQNLQNSHNSEQRNNVQNMHQNQYNSSQNPPIPIRQIGAASSHQHDQGSQGPGGKPQAYHLVQQGSQQQQQQQQQATLQRRNAAAAAGSNVQFIQQQQQQQQSGKNCGQGQSFVVMGSQSSSNDGQGGASTVGGGGGGSQQPHQQQQQQPQQRIQYIPQVTGSGNNGGGGGRGGYGSTLVMPRGGRVVRPAGTLPGGGRLYVDHNRHPYPMSSNVVPVRVLPATQQGQQRMMTGQRRPAPAPGTVAAMVLPNRGAGGIPQMRSLQRGSYTGGGGQQRINVMVQPQQMRSNNGGGVGGQGGLQGGPGGPQGIRRPLVGRPLQRGVDNQAPTVAQVVVAPPQGMQQASQGPPVLHMQRAVSMQMPTSHHHQGQQQAPPQSSQQASQQAPTSDSGTSAPPRQAPPPQN
What is the function of this protein?
Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling.  Involved in foregut development, and may be involved in vulval development.
What are the official names of this protein?
Helicase ssl-1, Swi/snf2-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDTJ_YERPY
Sequence: MIYWIFLGLAIIAEIIGTLSMKYASVSGEMTGHIVMYFMITGSYVMLSLAVKKVALGVAYALWEGIGILIITIFSVMWFGETLSPLKIAGLVTLIGGILLVKSGTRKPKQPNRHRGNRPPSVQGLKTQTTGHHKGVAVESGEHHAAA
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtJ.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS10_STACT
Sequence: MAKQKIRIRLKAYDHRVIDQSAEKIVETAKRSGAEVSGPIPLPTEKSVYTIIRAVHKYKDSREQFEQRTHKRLIDIVNPTPKTVDALMGLNLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RK32_NICSY
Sequence: MAVPKKRTSTSKKRIRKNIWKRKGYSIALKAFSLAKSLSTGNSKSFFVRQTKINK
What are the official names of this protein?
50S ribosomal protein L32, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ISPE_FRATN
Sequence: MANIKAKKYYSYAKINLFLHILNKRTDGYHNLQTWFTFLDLKDQLIFSFNNSREINISSNISIAAKQDNLVYKAIKKFQQSYRVQDIGVDIEIKKNIPMGAGLGGGSSNAATTLIALRDYYLPQLSNEEMIPLAAKLGADVPIFVYGKSAWAEGIGEILYHKDFSPQYALLIKPDIHISTKEFFVSEDLIKSSVLISKDLGFDKSIMHNDFENVFYAKYPEFSQYLKELDSDFRMTGTGSCFYLLSADKNKLEQLARKINKPLDKWLVKTLNYVY
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: LFTR_XYLFM
Sequence: MHSQPYLLSPAPNNTPFPPAEHALREPNGLLAIGGDLTPQRLLAAYRSGIFPWFTEGQPPLWWSPDPRTVFHSDSIHLSRRFRRSLRTSTWRVRADTMFAAVIDACASTPRRGQDGTWITANMREAYLTLHQHGYAHSVEVFDGTMLVGGIYGVAIGRMFFGESMFSTHNGASKIALASLAYFLHTHSVPLIDAQVENQHLLNLGAERWPRRDFLTYVRRLITQTELPACWSVLFGEKLSRDLV
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCKA_RHOPA
Sequence: MQETGVHNGAYGTDKFGLKNLKGVYWNFGAPQLYEHALKNGEAVLSSDGALVADTGVFTGRSPKDKFTVRDATTENTMWWGGNQSITAEQFEALYQDFLKHAEGMTLFAQDLYGGADPTFRIKTRVYTELAWHSLFIRTLLRRPERAELENFVPELTLIDLPSFRADPKRHGCRSENVVAIDFARKIVLIGGTQYAGEMKKSVFTTLNYYLPEKGVLPMHCSANVGPNGDTAIFFGLSGTGKTTLSADPNRTLIGDDEHGWGKDGVFNFEGGCYAKCIKLSSENEPEIYAASTRFGAVLENVVLGELDRKPDFDDGSKTENTRSAYPLESIPNASLTGRAGQPKNVVMLAADAFGVMPPIAKLTPAQAMYHFLSGYTAKVAGTERGVTEPTPEFSTCFGSPFLPRDPSVYGNMLRELIAKHNVDCWLVNTGWTGGIYGTGHRMPIKVTRALLTAALDGSLRNVEFRTDPYFGFAVPTALPGVPSEILDPVKTWADKAAFDTTARKLVGMFQKNFAKFEAQVDAEVRAAAPDVKMAVE
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFO1_METFO
Sequence: MAELPIAPVGRIIKNAGAPRVSDDARDALAKVLEEMGEGIAAEAVKLAKHAGRKTVKASDIEMAVKAA
What is the function of this protein?
Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils.  Increases the resistance of DNA to thermal denaturation (in vitro).
What are the official names of this protein?
Archaeal histone A1.
What is the protein family that this protein belongs to?
Belongs to the archaeal histone HMF family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: UPP_CORU7
Sequence: MDIKVVNHPLVRARLTIMRDARSNNVVFRDALADLGAMLIYEASNDLETESFDVETPVSTAEGHRLKNPPIIVPIIRAGLGMIDPALSMIPDAQVGFIGLARDEKTHEPVPYLEALPDDLSGQPVMLVDPMLATGGSLLNAVELLVEHGADDITCVCMVSAQPGVDKLVNSGLPVRKLVTATIDPALDENAYIDPGLGDAGDRLYGPRNIDLESR
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: GATA_CAUSK
Sequence: MSSLTSLTLKGALDGLEKGDFTSVELTRAHIDAIEAARGLNAFLLETPEQALSMAAASDARRALDAARPLDGIPLGIKDLFCTQGVRTTAASKILEPFVPQYESTVTSQLWRDGAVMLGKLNLDEFAMGSSNETSAYGPVVNPWRKAGSNQALTPGGSSGGSAAAVAADLCLGATATDTGGSIRQPAAFTGTVGIKPTYGRCSRWGVVAFASSLDQAGPIAKTVTDAALLLTSMSGHDPKDSTSLDVPVPDFSAFVGKSIKGLRIGVPQEYRVDGMPAEIEKLWADGIAWLKDAGCEIVEISLPHTKYALPAYYIVAPAEASSNLARYDGMRYGLRAEGSNLTEVYENTRAEGFGDEVKRRILIGTYVLSAGYYDAYYLKALKVRRRIAEDFDNAWERCDAILTPTAPSAAFGLGENSSDPIAMYLNDVFTVTTNLAGLPGLSLPAGLDANGLPLGLQIIGKPLDEGTVFSVAGVLEKAAGFTAKATKWW
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: DAPA_THERP
Sequence: MLRGTFVALITPFAGEEIDEPRLRDLVDWLIANRVDGLVPCGTTGETPSLSDTEWQRVAAVVIEQAAGRVPVIVGTGTNSTMVTIQRTRVARELGATAAMVVTPYYNKPQQDGLYRHVAAIADAVDLPLVIYNVPSRTGVNLAPETARRLLDIAPVIAFKDSSGSLDQVSELVLAVGDRSSVLSGDDSLTLPIIAVGGQGVVSVLANIAPAATATMVRAALDGDLARARQLHGELFPLARALFIETNPVPVKTAAELLGLCSATVRLPLAPLAPANRERLLAALASCPHTASLLARPMGEAA
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DFAR2_MOUSE
Sequence: MKKLVLLFALVLLAFQVQADSIQNTDEETKTEEQPGEKDQAVSVSFGDPQGSALQDAALGWGRRCPQCPRCPSCPSCPRCPRCPRCKCNPK
What is the function of this protein?
Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats.  Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins.  It may have microbicidal activities.
What are the official names of this protein?
Alpha-defensin-related sequence 2, CRS4C1, Cryptdin-related protein 4C-1, Defensin-related cryptdin-related sequence 2.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PTGR3_MOUSE
Sequence: MLRLAAAGARAIVDMSYARHFLDFQGSAIPRTMQKLVVTRLSPNFHEAVTLRRDCPVPLPGDGDLLVRNRFVGINASDINYSAGRYDPSLKPPFDIGFEGIGEVVALGLSASARYTVGQAVAYMAPGSFAEYTVVPASIAIPMPSVKPEYLTMLVSGTTAYLSLEELGELSEGKKVLVTAAAGGTGQFAVQLSKIAKCHVIGTCSSDEKAAFLKSIGCDRPINYRTEPVETVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGRLIVIGFISGYQSPTGLSPIKAGVLPTKLLKKSASLRGFFLNHYFSKYQAAMERLLELYARGDLVCEVDLGHLAPDGRFIGLESVFQAVDYMYTGKNTGKLVVELPHPVSSKL
What is the function of this protein?
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha.  Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
What are the official names of this protein?
Prostaglandin reductase-3, PTGR-3, 15-oxoprostaglandin 13-reductase, Zinc-binding alcohol dehydrogenase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
What are the subcellular locations of this protein?
Peroxisome.