PharMolix/UniProtQA huggingface dataset:
Protein: X5_LOXGA
Sequence: GDTRRQIL
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LgSicTox-LOXN5, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family.
What are the subcellular locations of this protein?
Secreted.
Protein: DPP7_PORG3
Sequence: MQMKLKSILLGAALLLGASGVAKADKGMWLLNELNQENLDRMRELGFTLPLDSLYSFDKPSIANAVVIFGGGCTGITVSDQGLIFTNHHCGYGAIQSQSTVDHDYLRDGFVSRTMGEELPIPGLSVKYLRKIVKVTDKVEGQLKGITDEMERLRKAQEVCQELAKKENADENQLCIVEPFYSNNEYFLIVYDVFKDVRMVFAPPSSVGKFGGDTDNWMWPRHTGDFSVFRVYAGADNRPAEYSKDNKPYKPVYFAAVSMQGYKADDYAMTIGFPGSTDRYLTSWGVEDRIENENNPRIEVRGIKQGIWKEAMSADQATRIKYASKYAQSANYWKNSIGMNRGLARLDVIGRKRAEERAFADWIRKNGKSAVYGDVLSSLEKAYKEGAKANREMTYLSETLFGGTEVVRFAQFANALATNPDAHAGILKSLDDKYKDYLPSLDRKVLPAMLDIVRRRIPADKLPDIFKNVIDKKFKGDTKKYADFVFDKSVVPYSDKFHAMLKSMDKEKFAKAIEKDPAVELSKSVIAAARAIQADAMANAYAIEKGKRLFFAGLREMYPGRALPSDANFTMRMSYGSIKGYEPQDGAWYNYHTTGKGVLEKQDPKSDEFAVQENILDLFRTKNYGRYAENGQLHIAFLSNNDITGGNSGSPVFDKNGRLIGLAFDGNWEAMSGDIEFEPDLQRTISVDIRYVLFMIDKWGQCPRLIQELKLI
What is the function of this protein?
Catalyzes the removal of dipeptides from the N-terminus of oligopeptides (PubMed:11096098, PubMed:23246913).  Shows a broad specificity for both aliphatic and aromatic residues in the P1 position, with glycine or proline being not acceptable in this position (PubMed:11096098).  Most potently cleaves the synthetic substrate Met-Leu-methylcoumaryl-7-amide (Met-Leu-MCA), Leu-Arg-MCA and Lys-Ala-MCA to a lesser extent (PubMed:23246913).  Is likely involved in amino acid metabolism and bacterial growth of asaccharolytic P. gingivalis, that utilizes amino acids from extracellular proteinaceous nutrients as energy and carbon sources (PubMed:11096098).
What are the official names of this protein?
Dipeptidyl-peptidase 7, DPP-7, DPP7.
What is the protein family that this protein belongs to?
Belongs to the peptidase S46 family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: CUTI2_ASPNC
Sequence: MKLPYFLLGLAGLAAASPMGLAERQLSDGNELRDGSCKPIIFIFARASTEPGLLGISTGPAVCNDLKMAKAGQVLCQGVGPAYTADLMSNALPDNTSPAAISESESLFKLAASKCPNSQILAGGYSQGTAVMDDSIKQLPDDVKDKIKGVVLFGYTRNAQEGGQIGNFPKDKVKIYCAMGDLVCDGTLIVTAAHFTYVMNTGEASQWLESKLSDTTTSSLTGSSSSDTSSSTSTGDSSSESSSAAGLGGLSGLTGLGSSTSGGFPSLASLF
What is the function of this protein?
Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (By similarity).  Degrades cutin, a macromolecule that forms the structure of the plant cuticle (By similarity).
What are the official names of this protein?
Probable cutinase 2, Cutin hydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: PO5F2_RAT
Sequence: MAGRRSSNVCPFPGNSGGGLEGPVPMRVDTPTWLSSQAATSRLMVRPGMGPGFCPGPEVWGVPLGPSPYEFRGGIAPYGAYETRTWSQNSSEDTYPGPYIALRYMPNLALPEDVSAIQKEMEQLAKELRQKRMTLGYSQADVGFAVGAMFGKVLSQTTICRFEAQQLSLANMWKLRPLLKMWLEEVDEKNLLGICRMEMILQQARKRRRASRERRIGSNLEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNRSQMAGWPTNDSSQRENVGATGAPFPGPPVCFPLAPGLHFDFPHYGGSCLTPLYSSTPFPVRGALLSAPTTTLGLPRLSS
What is the function of this protein?
Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3').  May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell.
What are the official names of this protein?
POU domain, class 5, transcription factor 2, Sperm 1 POU domain transcription factor, SPRM-1.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYFA_PROMT
Sequence: MSSTLSLKQLIGELEILESEAAKEIASAENSESIEKLRLSFLGKKGKLSLLLGGMKNLSNEERPLIGQRANVLKTQLQELIKEKLEILKTQALSQILIKETIDVTAPPTGITQGHRHPLITTTEQIIDLFLGLGYQVSEGPEIENDYYNFEALNIPPDHPARDMQDTFYLGGEYLLRTHTSPVQIRCLESKKPPVRIVSPGRVYRRDAVDATHSPVFHQVEVLAIDEKLDFSHLRGTVMAFLKAFFGDLPIRFRASYFPFTEPSAEVDVQWRGKWLEVMGCGMVDPAVLEELGIDPEKYSGFAAGLGVERFCMVRHGLDDIRKLYTSDLRFLEQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1798_STAA9
Sequence: MNTFQMRDKLKERLSHLDVDFKFNREEETLRIYRTDNNKGITIKLNAIVAKYEDKKEKIVDEIVYYVDEAIAQMADKTLESISSSQIMPVIRATSFDKKTKQGVPFIYDEHTAETAVYYAVDLGKSYRLIDESMLEDLKLTEQQIREMSLFNVRKLSNSYTTDEVKGNIFYFINSNDGYDASRILNTAFLNEIEAQCQGEMLVAVPHQDVLIIADIRNKTGYDVMAHLTMEFFTKGLVPITSLSFGYKQGHLEPIFILGKNNKQKRDPNVIQRLEANRRKFNKDK
What are the official names of this protein?
UPF0354 protein SaurJH9_1798.
What is the protein family that this protein belongs to?
Belongs to the UPF0354 family.
Protein: LICI1_TACTR
Sequence: MKLGDWKFCLLLFQLMFLTNVCLSDLSFNPYKWPVNQLRRVIGAVKVTNTSNYFGFSLYENLNSNGNVFISPYSLASVMAMLYLGARGVTKNEMDLTLGYNSVNLNSEDLVLGFQQSLLLLNAESKEYQLETANSLMIQNTFNILDNYKRMLEDKFGANVQDVDFINKAELVQRYINAWVAFKTKNKIPILLNEPLKPETRLAFFNAVYFKGVWETKFDSALTRRATFYNNGYVPTQVPMMMLRGIFPFAYVSSLRSYVLELPYKGHEVSMLLLLPKDRNGISDLERDLSSSSLDSVTSNLREIGVLVTIPKFKLEETYEDDLKQSLESMGMTSLFSEANANLEGITGHRDLFVTKITHRTLIEVNEEGTEASGISSVVAGVRSGWKRPTFTADHPFVFFIRHNRSGIILFMGRVSQL
What is the function of this protein?
Serine protease inhibitor that specifically inhibits clotting factor C (PubMed:8276848).  Does not inhibit clotting factor B or proclotting enzyme (PubMed:8276848).
What are the official names of this protein?
Intracellular coagulation inhibitor 1, Limulus intracellular coagulation inhibitor 1, LICI-1.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted. Note=Localizes in the large granules of hemocytes (By similarity). Secreted in hemolymph in response to external stimuli (By similarity).
Protein: LPXK_CERS4
Sequence: MRPPAFWFTPPDSPALAARLLAPLGQAYAAATARRLRAPGHRAGVPVICIGNLNAGGTGKTPTAIALMQRLAARGIEAHVVSRGYGGRLEGPVEVDARRHRAADVGDEPLLLAAFGRAWVARDRAAGVRAAEAAGAQAILLDDGFQNPSVVKDLSLIVVDAAVGFGNGRCLPAGPLREPVEAGLARADLLLSIGGPEAQRRFATDWPALPVPRLTGRLATLQMGMDWQGARVLAFAGIGRPEKFFASLRAEGAELLRAEALDDHQPLGEALMKRLEIEAMALGAQLVTTEKDAVRLPPSFRQKVLTLPVRLEFDDATALDAALDRLGLAARS
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: SID2_SCHPO
Sequence: MNRVNDMSPVEGDLGLQLSSEADKKFDAYMKRHGLFEPGNLSNNDKERNLEDQFNSMKLSPVASSKENYPDNHMHSKHISKLPIASPIPRGLDRSGELSYKDNNHWSDRSSTGSPRWENGSMNLSVEEMEKVVQPKVKRMATICQMFFLDHYFEQLHYLYTRKQRARLFEEQLLKEPDSRRDELVKRYNGRERVYLRKRRTRISHGDFQTITQVGQGGYGSVWLARKRDTKEIVALKIMNKSVLHKMDEIRHVLTERDILTTANSEWLVRLLYAFQDTSNIYLAMEFVPGGDFRTLLSNSGVLRDHHAKFYATEMFLAIDALHQLGYIHRDLKPENFLVGASGHIKLTDFGLSSGIISKKKIESMKIRLQEVNNVVVPERSMRERRQVFRTLLSQDPVYAHSVVGSPDYMAPEVLRGENYNHSVDYWSLGCIMYECLSGFPPFSGSNVNETWSNLKNWRKCFQRPHYDDPRDLEFNWRDDAWDFVCHCITDPKDRFCSLKQVMQHPYFSKIDWKNVRTAYRPPFVPDLNSEIDAGYFDDFTNENDMSKYKEVHEKQAAIANMVNTFNKPKRNAFIGFTFRHQKNSHPTSSSSALSSPLSAPSFGTLL
What is the function of this protein?
Part of a signaling pathway.  Required for initiation of medial ring constriction and septation.
What are the official names of this protein?
Serine/threonine-protein kinase sid2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm.
Protein: DNAK_PARP8
Sequence: MGKIIGIDLGTTNSCVALMEGNQVKVIENSEGARTTPSIIAYMDDNEVLVGAPAKRQSVTNPKNTLYAVKRLIGRRFEEKEVQKDIGLMPYKIVKHDNGDAWVEAHGNKLAPSQVSAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKAEKGDRKIAVFDLGGGTFDISIIEIADVDGEKQFEVLSTNGDTFLGGEDFDQRIIDYIIGEFKKEQGVDLSKDVLALQRLKEAAEKAKIELSSGQQTEINLPYITADASGPKHLNLKITRAKLEALVEDLIERTIEPCRVAIKDAGVKVGEIDDVILVGGQTRMPKVQEKVKEFFGKDPRRDVNPDEAVAVGAAIQGQVLSGDRKDVLLLDVTPLSLGIETLGGVMTKMINKNTTIPTKHAQVYSTADDNQGAVTIKVFQGEREMAAGNKLLGEFNLEGIPPAPRGVPQIEVSFDIDANGILHVGAKDKATGKENRITIKANSGLSEAEIEKMVKDAEANAEEDHKLRELADARNQGDALVHSTKKALTEYGDKLEAGEKEKIEAALKDLEETLKNGSSDKAAIEAKIETVATASQKLGEKMYADMQAQGAAGAAGAAGGAGAAAGAEAAGASQQADDVVDAEFKEVKKD
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MES6_CAEEL
Sequence: MEHTKKFKSLNLHGFDRSTEDYGKRPFVLTAKLLEDQKKAIYGCAFNQYAGIDEEQAVATVGGSFLHMYSVPIDINNIELQWSCNFPTDKSSKVEREESLFTVTWCYDTYEAENDRNPFKVVTGGTLGHIYVIDYVSRKLSNRLRSVGWEINDIRTCPANSNLIVCASSDQSIRIHHIRNEACLIVIGGLECHAGTILSVDWSTDGDFILSCGFDHQLMEWDLSVKQVKEHLERACKALHQDKINVLTQSQDIPYVSKGTMRKSAVSRNIPDKEEDQLLELHRELIPRPSCLLPIYTPSSVSTDMHSDYVDCIRFLIGTNYALSKGCGNEKAIHFWRFGPPKGEVENRIHGNVLRPKSCTTKFRTMNVPSGSAWFIKFAVDPRRRWLVCGGAGGSVMFFDLRNNEETNPTHTCSVGSRTVRQASFSTCGRFLVLVTDEGFVCRFDRVSASVDAKDLAKF
What is the function of this protein?
Polycomb group (PcG) protein.  PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.  In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head (PubMed:17574230).  PcG proteins are not required to initiate repression, but to maintain it during later stages of development.  The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells.  The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility.  This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells (PubMed:12077420, PubMed:15380065).  Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259).
What are the official names of this protein?
Polycomb protein mes-6, ESC homolog, Maternal-effect sterile protein 6.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ESC family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FABR_KLEP7
Sequence: MGVRAQQKEKTRRSLVEAAFSQLSAERSFASLSLREVAREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRAFTEAQAEAMVTIVFSAGAEALDVGPEQRRQLEERLVLQLRMISKGAYYWYRREQEKMSHHSE
What is the function of this protein?
Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis.  By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.
What are the official names of this protein?
HTH-type transcriptional repressor FabR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_KLEP7
Sequence: MKNINPTQTSAWQALQKHFDEMKDVTISELFAKDSDRFSKFSATFDDLMLVDFSKNRITEETLAKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHVALRNRSNTPIVVDGKDVMPEVNAVLEKMKTFSEAIISGSWKGYTGKPITDVVNIGIGGSDLGPFMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKNVNPETTLFLVASKTFTTQETMTNAHSARDWFLATAGDDKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGHAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLEHVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGAILNIFTFDQWGVELGKQLANRILPELKDGSEVSSHDSSTNGLINRYKAWRA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTLD_STAA8
Sequence: MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVEDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: FABZ_VARPS
Sequence: MTTTTLDIHQILKLLPHRYPFLLVDRVLDMEKGKRITALKNVTMNEPFFNGHFPHRPVMPGVLMLEAMAQAAALLSFHSLDIVPDDNTVYYFAAIDGARFKRPVEPGDQLTLEVEIERMKAGISKFKGRALVGSELACEATLMCAMRQIN
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_ECOBW
Sequence: MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTVPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDGRRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHRLSEQYHR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_IDILO
Sequence: MRIVFAGTPDFAAQHLQQLLDESHQVVGVYTQPDRPAGRGKKPQPSAVKKLALEHQLPVYQPESLKSEEDQAALADLKPDVMVVVAYGLLLPQAVLDIPTKGCLNVHGSLLPRWRGAAPIQRAIWAGDLESGVCIMQMEAGLDTGPVLHEERCAISPDETSASLYHKLESLGPEALTKVLKDLDGYQSQAKPQSDANATYAKKLTKQEGKIDWTQPAAFIERCVRAFNPWPMSWCQSEHLKAGQNTVKIHAAELIQGASNKGPGTIINSTHEGIDVVTGDGILRITQAQMPGKKAQPASTLVNGYSNVFSPGLELQ
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: RL7_RHOPA
Sequence: MADLQKIVDDLSSLTVLEAAELAKLLEEKWGVSAAAAVAVAAAPGAGGAAAPAEEKTEFTVVLASAGDKKIEVIKEVRAITGLGLKEAKDLVEGAPKPLKEGVNKEEAEKVKAQLEKAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12, RRP-L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: DASR_STRGR
Sequence: MGAEGAVRGARPVPVRAQRVPKYYRLKRHLLDMTDTLPPGTPVPPERTLAAEFDTSRTTVPQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQGLEPTSQLLDIGYVTADDTLAGLLDISTGGRVLRIERLRLASGEPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVRLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSVDGQGEPVEWVRSVYRGDRYKFVARLKRGTD
What is the function of this protein?
Global regulator that is part of the nutrient-sensing system.  In the absence of glucosamine 6-P (GlcN6P), represses the phosphotransferase system (PTS) specific for the uptake of N-acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis (By similarity).  Regulates the dasABC transport operon involved in glucose-related morphogenesis.  Essential for development (PubMed:11741848).
What are the official names of this protein?
HTH-type transcriptional repressor DasR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_METHJ
Sequence: MSVMVLGTASHVGKSTMVAGLCRILRRRGISNAPFKSQNMSLNSWVTEDGGEIGIAQAMQAHAAGIPPCVEMNPILLKPKGDQTSQIVLLGRPHHDVHACDYYKVTDNLLTIALEAAGKLMSRYGALVVEGAGGAAEVNLFDRDIANIGLARALKFPIILVADIERGGVFAQVYGTISLLPDDIRPLVKAVIVNKFRGDPALFSDGMRILEEITGVPAIGLVPVTDVDIPSEDSLSLQDKKTKSAPVEIAVIHLPRISNFTDYEVLERYASVRYVKPGTPLSGFDAIILPGTKNTIEDLEEVIASGTGEEIKKARTQGVPIIGICGGYQMLCEEILDSGIESKEGTFHGLGLIPCRTTFSGYEKTTVQVTRTSSGHGPFLEKIASVSGYEIHMGTTCRGDIREAFSGEGVVSEDGLLIGTYMHGLFTSPHVAAAFVTFLCDRKGLTWTPPAQDKDPFDTLADHIEAHVRIEEILPFFN
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Probable cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: MDTK_YERPA
Sequence: MQKYIVEARSLLALAIPVVIAQLSQTAMGVVDTIMAGSVSATDMAAVAVGTSIWLPAILFGHGLLLALTPTVAQLNGSGRRSQIAHQVRQGFWLALCVSVLIMLVLYNSDHVIKQMDNIDPVLAQKAVGFLHAIMWGVPGYLFFQVLRNQCEGLSKTKPGMVIGFVGLLVNIPINYIFIYGKFGAPALGGVGCGVATASVYWVMFLMMRWYVTRARSQQDIKLEKGFAAPDWQVMKRLSGLGLPVALALFFEVTLFAVVALLVSPLGIVAVAGHQIALNFSSLMFMLPMSLSVAATIRVGFRLGQGAVEQAQVAAYTSMAVGLLLASVTAVFTIVFREHIALLYNKTPEVVTMASHLMLLAALYQLSDAVQVIGSGVLRGYKDTRSIFFITFTAYWLLGLPSGYLLGLTDYILPAMGPAGFWIGFIIGLTAAAILMVLRIRWLQKQPTAFILQRAAH
What is the function of this protein?
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
What are the official names of this protein?
Multidrug resistance protein MdtK, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: H2B3B_HUMAN
Sequence: MPDPSKSAPAPKKGSKKAVTKAQKKDGKKRKRGRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B type 3-B, H2B type 12, H2B-clustered histone 26, H2B.U histone 1.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RNH2_PICTO
Sequence: MCVCGIDEAGRGPVIGPMVMAMVCADDINFYVNDSKLLTRNKRSLIFNDVSGLYHKYYIINPAEIDDAVKKHSLNNLEEQYAEKLILKAECEKIYIDCFDVNESRLERILKDRTGKEVICRHHADRDIKIVSAASIIAKVLRDNEIEKLKSIYGDFGSGYPSDPKTLRFLEHSIINHDNIDNIVRKEWKTYKNLVQGHI
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PM2P2_HUMAN
Sequence: MGESSRKPPTPTPEGPTVSVKQLFSTLPVRHKEFQRNIKKKRACFPFAFCRDCQFLEGSPAMLPVQPAKLTEPAKAIKPIDRKSVHQICSGPVVLSLSTAVKKIVGNSLDAGATNIDLKLKDYGMDLIEVSGNGCGVEEENFEGLSLSALKHHTSKIREFADLTRVETFGFQGKALSSLCALSDVTISTCHVSAKVGTRLVFDHDGKIIKKTPYPHPRGTTVSVKQLFSTLPVRHKEFQRNIKKKRACFPFAFCRDCQFLEGSPAMLPVQPAKLTVTGELRACRSWKTREGITEAVG
What are the official names of this protein?
Putative postmeiotic segregation increased 2-like protein 2, Postmeiotic segregation increased 2-like protein 14, Postmeiotic segregation increased protein 4, Putative postmeiotic segregation increased 2 pseudogene 2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: MYPR_BOVIN
Sequence: MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAAPSKTSASIGTLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF
What is the function of this protein?
This is the major myelin protein from the central nervous system.  It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
What are the official names of this protein?
Myelin proteolipid protein, PLP, Lipophilin.
What is the protein family that this protein belongs to?
Belongs to the myelin proteolipid protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Myelin membrane. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt- Lanterman incisures of myelin sheat.
Protein: PYRH_ECOL5
Sequence: MATNAKPVYKRILLKLSGEALQGTEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDSYSWAEAISLLRNNRVVILSAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVFTADPAKDPTATMYEQLTYSEVLEKELKVMDLAAFTLARDHKLPIRVFNMNKPGALRRVVMGEKEGTLITE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_STRGG
Sequence: MNVVTPNGGDSVAARSWPGLLNPLLRGEDLSAEETAWAMDRIMSGEATDAQIAGFAVALRAKGETVDEVTGLVRAMYAHANTIEVPGRTVDIVGTGGDLAKTVNISTMSAIVIAGTGAKVVKHGNRAASSASGSSDVLEKLGVNLELTPRRVVEVAEAAGITFCFAVKFHPALRYAAKARKELGAQTTFNILGPLTNPAQVRSQAVGVADARMAPIVAGVLADRGNSALVFRGDDGLDELTTTATSRVWVVRDGVVREEPFDPRDVGLPIVPVEALRGADASYNADVARRLLDGEAGAVREAVLLNSAAALVALDPGTGTLTEQLAAKILVAAEAIDSGAAKQALERWIAASNA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.