PharMolix/UniProtQA huggingface dataset:
Protein: MDM34_USTMA
Sequence: MSFNFKWPTFSDEFHTSAAQMLNSALNRGPKPKVIADDILVEELGMGTIPPELEILEIGDLGTDRFRGIFRLTYAGDAHLVLKTKVQANPLSKPNRPDIGLFPSSNASRGILFAAAPLIVPMHLRLSSVKLRAIVVLVVSKAKGITLVFKNDPLESVEVSSTFDSVAVIQKYLQQEIEGQLREMFREDLPGIIHRLSQKWLSGEAKSEKDKVKQKAEAEEPPARSREPTLTRSTSEPLVALETASAPGGTPRKSHSKAKKHSRSGASVADFAASPCQSPQRPRQSPRRPRHVAKAASTSAVPLHSEFSATHASPFDAAFPDIENYDPTYGLRPDDLPTHSGFSGLGRLAQRGLGGLKDLTASPVFDLDTALGAADVDLDGAAVFEDLNRQSDDEGSEAEQSQDAHSSSHDGKHDEGDATTDSDLDAVLHDVGDDVSDLDVQERDNLVDTSIDYSRFGYPPASAAFSDAHELTRASSIIFDDQPQLTRKHSKRGSVSGRSSTRARRPSSSRSDRSACTSSLRKREEAEVVYETIPAVGGGIVTRPRVYHIASKVQPPEVDWDDEDTARPSQYGGTPSTRTGTTRFGSDYGSATMGAQSSRTNTVRGIHDLPHLNSAFVSRDGSEESLIDLPPESYHSSDASLPHALDAERSSVSGSDSRRGLTNPTSRESSYRDLSSQDLHWDHSASSTAPSSSQSLHWDMHSRNDAAARTVNVKAGQNAESNSGLSFRKNKSANHQRSITLGGGGGGGFPLRRPGEGPGMSATPARTRASAAASARSRPGFITYATSPPGDSSGWQRSPPLRASSDRDVAFSTSPGVAQDMLSISPFRDSSLHHGSPRETSNVAGAYASASNSPYTSGHNKGTQGAGAAPTHLSIDASAHFLDLVKSNHTLSPFTRSMEHFTVRSAPVTPGWQTASGNVSVVGSSAASGTGTTSGSSQTGANAKSGKAGSDKTRSQDHLSVGHTVAEPKTHCQADSAAPSSGLPARRRRTFQLGGSSSRDDTASNKPNNTSTGQGEDSQDNSAAPGSDDYGFARYAGSGPQPFRASGSSASSAITDSSSKGNRLGSKDLRRRSRPGSMGPPSEAARLSALRWEAIRE
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: PRP28_PICST
Sequence: MMALEPVSTTRDNIDFVETTHWSEKSLDQMTARDWRIFREDYGITSKGGDIDNPLRTWNEASIPSKLLSIIVDKLEYLEPTPIQRAAIPLALNQRDVVGIAETGSGKTLAFLIPLLSYILNTDKNYLEYEHQQEQNYNKPLGLILAPTRELAQQITKEAQKFGDRLGLNVVSIIGGHQYEETVHSIRTGVHVVVATPGRLVDSLERNIIGLDKCYYLIMDEADRMIDMGFEKALQSILSYVPSTDRLNSTIDSMIFHIKKRITLMFTATISPPIEKITKNFLIKPGYLYIGGAGEALDHIVQNFEYLGSATGGSEDFDSKRFDKLVRIIQQHSRESRQFSIIIFANYKRVCDLLSLELEKNGFRDNVVIHGSKTQELREKAISSFRSHESRILIATDVAARGIDVPNVSLVVNFQMSRKFDEYVHRIGRTGRAGNRGESYTFIDDSDSDVFIDLKKFLVNGGKKCPDWLIKHASTQSQVLRD
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA splicing.  May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site.  May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TBB1_BRUPA
Sequence: MREIVHVQAGQCGNQIGAKFWEVISDEHGVQPDGTYKGDSDLQIERINVYYNEANGGKYVPRAVLVDLEPGTMDSIRGGEFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDNVLDVIRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMSSFSVVPSPKVSDVVLEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLANPTYGDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLSARDAAAYRALNVAELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMREVDEQMMQVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNTTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEEGDLQEGESEYIEQEE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-1 chain, Beta-1-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: DCTA_ECO55
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDVLNNRAPDGKTHELSS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CUTA_ARCFU
Sequence: MHNFIYITAPSLEEAERIAKRLLEKKLAACVNIFPIKSFFWWEGKIEAATEFAMIVKTRSEKFAEVRDEVKAMHSYTTPCICAIPIERGLKEFLDWIDETVE
What is the function of this protein?
Involved in resistance toward heavy metals.
What are the official names of this protein?
Divalent-cation tolerance protein CutA.
What is the protein family that this protein belongs to?
Belongs to the CutA family.
Protein: PAFA_SACVD
Sequence: MQRRIFGIETEFGVTCTFHGQRRLSPDEVARYLFRRVVSWGRSSNVFLSNGSRLYLDVGSHPEYATAECDDLAQLVTHDKAGERILEDLLIDAERRLAEEGIGGDIFLFKNNTDSAGNSYGCHENYLVTRAGEFSRVADVLLPFLVTRQLVCGAGKVLQTPRGGVYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMAEPTTLLKVGSVHLVLQMIEEGVQFRDFTLDNPIRAIREISHDLTGRRQVRLAGGREASALEIQREYYARAVQHVESGDPSPTTQYLIDLWGRALDAVEQQDFSSIDTEIDWAIKHRLVERYRSKHNLTLSDPRVAQLDLAYHDIRRGRGVFDLLQRKGMVRRITDDGEIELAKDSPPQTTRAKLRGDFIAAAQEAGRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDERVERLINSL
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: GTRB_SHIFL
Sequence: MKISLVVPVFNEEEAIPVFYKTVREFQELKPYEVEIVFINDGSKDATESIINALAVSDPLVVPLSFTRNFGKEPALFAGLDHASGDAVIPIDVDLQDPIEVIPHLIEKWQAGADMVLAKRSDRSTDGRLKRKTAEWFYKLHNKISTPKIEENVGDFRLMSREVVENIKLLPERNLFMKGILSWVGGQTDVVEYVRAERVAGISKFNGWKLWNLALEGITSFSTFPLRVWTYIGLFVASISFLYGAWMIIDTLVFGNPVRGYPSLLVSILFLGGVQLIGIGVLGEYIGRIYIEVKNRPKYIIKKSHRGNP
What is the function of this protein?
Involved in O antigen modification.  Catalyzes the transfer of the glucose residue from UDP-glucose to a lipid carrier (By similarity).
What are the official names of this protein?
SfII prophage-derived bactoprenol glucosyl transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GtrB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CM3E_CONCN
Sequence: MSKLGVLLTICLLLFPLTALPMDGDQSVDRPAERMQDDISSEQYPLFNQKRRCCGEGASCPVYSRDRLICSCC
What is the function of this protein?
Shows a paralytic effect in fish.
What are the official names of this protein?
Conotoxin CnIIIE.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YQZF_BACSU
Sequence: MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGLSGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR
What are the official names of this protein?
Uncharacterized protein YqzF.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OPLA_ARATH
Sequence: MGTVIEGKLRFCIDRGGTFTDVYAEIPGHSDGHVLKLLSVDPSNYDDAPVEGIRRILEEYTGKKIPRTSKIPTDKIQWIRMGTTVATNALLERKGERIALCVTKGFKDLLQIGNQARPDIFDLTVAKPSNLYEEVIEVDERVVLALEDDDDDEGSLIKGVSGEFLRVVKPFDGEGLKPLLKGLLDKGISCLAVVLMHSYTYPKHEMDVEKLALEMGFRHVSLSSALTPMVRAVPRGLTATVDAYLTPVIKEYLSGFISKFDDDLGKVNVLFMQSDGGLAPESRFSGHKAVLSGPAGGVVGYSQTLFGLETEKPLIGFDMGGTSTDVSRYDGSYEQVIETQIAGTIIQAPQLDINTVAAGGGSKLKFQFGAFRVGPDSVGAHPGPVCYRKGGELAVTDANLVLGFVIPDYFPSIFGPNEDQPLDVAATREAFEKLAGQINIYRKSQDPSAKDMSVEEIAMGFVSVANETMCRPIRQLTEMKGHETKNHALACFGGAGPQHACAIARSLGMKEVLVHRYCGILSAYGMGLADVIEDAQEPYSAVYGPESLSEVFRRETVLLREVREKLQEQGFGDGNISTETYLNLRYDGTDTAIMVKGKKTGDGSAFDYAAEFLKLFEQEYGFKLQNRNLLICDVRVRGIGVTSILKPRAVEAAPVTPKVERHYKVYFEGGWHDTPLFKLENLGFGHEILGPAIIMNGNSTVIVEPQCKAIITKYGNIKIEVEPATSSVKLAENVADVVQLSIFNHRFMGIAEQMGRTLQRTSISTNIKERLDFSCALFSPDGGLVANAPHVPVHLGAMSSTVRWQLKHWGENLNEGDVLVTNHPCAGGSHLPDITVITPVFDKGKLVFFVASRGHHAEVGGITPGSMPPFSKAIWEEGAAIKAFKVVEKGVFQEEGIVKLLQFPSSDETTTKIPGTRRIQDNLSDLQAQIAANQRGISLIKELIEQYGLGTVQAYMKYVQLNAEEAVREMLKSVANRVSSETPNSRVGNSVTIEEEDYMDDGSIIHLKLTIDADKGEASFDFTGTSPEVYGNWNAPEAVTSAAVIYCLRCLVNVDIPLNQGCLAPVEIRIPAGSFLSPSEKAAVVGGNVLTSQRVTDVVLTAFQACACSQGCMNNLTFGDDTFGYYETIGGGCGAGPTWNGTSGVQCHMTNTRMTDPEIFEQRYPVLLHRFGLRENSGGNGLHKGGDGLVREIEFRKPVVVSILSERRVHSPRGLNGGQNGLRGANYLITKDKRRIYLGGKNTVHVEAGEILQILTPGGGGFGSNI
What is the function of this protein?
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.  Acts in the glutathione degradation pathway.
What are the official names of this protein?
5-oxoprolinase 1, 5-oxo-L-prolinase, 5-OPase, Protein OXOPROLINASE 1, Pyroglutamase.
What is the protein family that this protein belongs to?
Belongs to the oxoprolinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_ACIF5
Sequence: MSRVAKQPVPLPKGVEVHVADQRLVVKGPKGEMSVPFHPAVELRIDDGGASLTWSDNQNAQAGTMRAILNNMVQGVSQGYEQKLEIIGVGYRAQAKGKTLSLSLGFSHPVDYSVPDDITIETPTQTEIVIRGIDKQKIGQIAADIRAYRPPEPYKGKGVRYAGENVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: GPPA_SALEP
Sequence: MNSTSLYAAIDLGSNSFHMLVVREAAGSIQTLTRIKRKVRLAAGLNNDNHLSAEAMERGWQCLRLFAERLQDIPQPQIRVVATATLRLAVNAGEFIAKAQTILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFSDRNLAQENFDDAEKAARDVLRPVADELRFHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQLKQRAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFTELNIQSMTLAGGALREGLVYGMLHLAVDQDIRSRTLRNIQRRFIVDTDQANRVAKLADNFLKQVENAWHIEPISRELLLSACQLHEIGLSVDFKQAPYHAAYLVRHLDLPGYTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAILFAGRRRDDLVPEITLQALNENLTLTLPGDWLAHHPLGKELIDQESQWQSYVHWPLDVR
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: YFY8_SCHPO
Sequence: MFYSDYLKLLKIFVVGVFPCTLFVNAPHGKLAKQSKLFSKGYISGRVGWVLMELVAPLTFLYAIRNNRHFESTLPSLGDGSNRDYLDSCRKVLAGMFLVHYANRALVSPLLMAPQVSPMHWTVFVSAVLFNFLNGMSIGLYLVQASVQHHPVSIIRRYIGMFLWLMGWLGNMYHDNILYDLRRSSNKKKDPDNLDTVQSENSYYRIPYGGLFQYVSCPNYFCEWIEWFGCYLAAGPSAEPFWWFFLSEILLMLPRALKAHQWYCKKFPKYPANRRAIIPFLM
What are the official names of this protein?
Uncharacterized protein C9.08c.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ARGP_EDWI9
Sequence: MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENLFGQPLLVRTVPPRPTEQGQRLLALLHQVELLEEEWLGNDNSSDGPLLLSLAVNADSLATWLLPALKPVLADSPLRLNLQVEDESRTQERLRRGEVVGAVSLQPQPLPSCLVDRLGALDYLFCASPAFAARYFPNGVTRSSLLKAPAVAFDHLDDMHQAFLQQNFELPPGSVPCHIVNSSEAFVQLALQGTTCCMLPHLQVERELRKGVLIDLTPGMVQRRMLYWHRFAPESRLMRRVTDALISHGRDVLRQD
What is the function of this protein?
Controls the transcription of genes involved in arginine and lysine metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator ArgP.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: TPS10_DICPU
Sequence: MEAIKQKRSLISLKESFIYPHEWNHEPCDNKFILECFKESVNLGIFQIDDKKSFSYINSCLSSCAYMWPLCNHSQSLMTGRFIQWSFLIDDYLDSLEIDDKKTDSTVLNVEKALINGTITNKNSKLEEYTVFFRNKLFEYCGRERLDAFNLLINELVICLWTLVPFSKIHSKEKDFYPSYQLYRCIRTINVGIIACCALNFILFKDLDVKLWLNPRFRKILNRASIQISIVNDAVSYAKEILNENAYCNTFYFLQKDSTKFSTFDQVCEYLFNEANTYIKDIITDEPLLLHEFEDVEDRKVVQSLLNHVHYLISGNFVWSIENNQRYQSNIYFINLLQSTGKSIGSSWSNIKTFFR
What is the function of this protein?
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into several unidentified sesquiterpenes (PubMed:30254228).  TPS10 also converts geranylgeranyl diphosphate (GGPP) into the diterpene beta-araneosene (PubMed:31621716).
What are the official names of this protein?
Terpene synthase 10.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: RWD2A_HUMAN
Sequence: MSASVKESLQLQLLEMEMLFSMFPNQGEVKLEDVNALTNIKRYLEGTREALPPKIEFVITLQIEEPKVKIDLQVTMPHSYPYVALQLFGRSSELDRHQQLLLNKGLTSYIGTFDPGELCVCAAIQWLQDNSASYFLNRKLVYEPSTQAKPVKNTFLRMWIYSHHIYQQDLRKKILDVGKRLDVTGFCMTGKPGIICVEGFKEHCEEFWHTIRYPNWKHISCKHAESVETEGNGEDLRLFHSFEELLLEAHGDYGLRNDYHMNLGQFLEFLKKHKSEHVFQILFGIESKSSDS
What are the official names of this protein?
RWD domain-containing protein 2A.
Protein: SYR_MYCUA
Sequence: MTPADLAELLKTTATAVLSEHALDTSALPQTVVVERPRNPEHGDYASNVALQLAKKVGANPRELAGWIVEALTKADGIASAEVAGPGFINLRLETSAQAKIVNAIIDAGSGFGHSELMAAHKVNLEFVSANPTGPIHIGGTRWAAVGDALGRLLSTQGADVVREYYFNDHGAQIDRFANSLIAAAKGEPTPDDGYAGSYINDIAARVLQKAPDALSLPDAQMHETFREIGVDLMFSHIKESLHEFGTDFDVYTHEDSMHSTGRVDQAVARLRETGNIYEKDGATWLRSSSFGDDKDRVVIKSDDKPAYIAGDLAYYLDKRERGFDLCIYMLGADHHGYIARLKAAAAAFGEDPGTVEVLIGQMVNLVRDGQPVRMSKRTGTVITLDDLVEAIGVDAARYSLIRSSVDTPIDIDLALWSSASNENPVYYVQYAHARLSALARNAAELGLIPDTDHLELLSHEKEGVLLRTLGDFPRMLKAAASLREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEEPTQLHTARLALCQATRQAIANGLGILGVTAPERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GEFH_DICDI
Sequence: MSNTNINVQSSTPKKSLGSSQYSLAGSSSSNLNNINNNNNNNNNNNNNSTGQENSIDDSGSSSFVNFPASEWLSKAMHKHPDILELRERTRPITQVKSYSRNKRSSKTEASHSINDTMLLKLIMQYFHEENLTTSLKKIQEETKVQFTPNEVDKDSLENLLRIGIKDTNWFGPLEDIEDADPEVETYHSYISEDSLNENGLEGEGNLIEDRYDESQISRNPDGTIKAATFNRLLLWLIGNFNGPDVNEFKKIFFLTYPSFTTAEAILNKFTQIYQLFDNIESAQVICFIRFWIEQHPTDFNEKLLAILNNFIEHQVAASHAKQLRAVINLKIENYKEARKEIKDPPEPKVPKNIFSPTLTFDDIDEEEIARQLCCIDFALYELIKPSEFLIKGWTKPQYRNKAVNLLNMMRRFNDFTKWIAASILNEQNSKGRSKLLGRFLKISEHLRANNNFHSLMAIYGGINNTHVFRTKAIRKDLSRQQQETYAELEKLFASENSFRNYRIAYKDAKPPCIPFLGIHLRDLAFVDESNPDRINNLLNLNKRRVIWRVIVNTMRYQPIPYYFLKVHQISLFLTELKTESEQPQLTLDLSSHDTVLPSSPSSK
What is the function of this protein?
Promotes the exchange of Ras-bound GDP by GTP (PubMed:20493808).  Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay (PubMed:20493808).  The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway (PubMed:20493808).
What are the official names of this protein?
Ras guanine nucleotide exchange factor H, RasGEF domain-containing protein H.
What are the subcellular locations of this protein?
Cell membrane. Note=The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells (PubMed:20493808). Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1 (PubMed:20493808).
Protein: ACCD_BAUCH
Sequence: MSWIERIINKSIITPTRKANIPEGIWTKCDSCGQVLYRAELERNLEVCLKCNHHMRISARVRLHAFLDQCSKYELGSELEPKDILKFRDSKKYKDRLIAAQKATKEKDALVVMKGTLYGMPIVAASFEFGFIGGSMSSVVGTRFVYAVEQALLDKCPFVCFSASGGARMQEALMSLMQMAKTSAALAKLRAQCLPYISVLTDPTMGGVSASLAMLGDLNIAEPKALIGFAGPRVIEQTMREKLPAGFQRSEFLLARGAIDMIVNRLDMRWRIARLLAKLTSRPPLKSTNSQENTC
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_PSEPK
Sequence: MISDESDRFNPRDPKPADAGKPSKSAKRREARKLATQALYQWHMAQHSLNEIEAQFRVDNDFTDVDGAYFREILHGVPAIKGEIDKALVPCMTIALEELDPVELAVLRLSTWELIKRVDVPYRVVINEGVELAKVFGATDGHKFVNGVLDKLAPALREAEVKANKR
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: COFG_METKA
Sequence: MVSYSKNVFVPLTRLCRNRCAYCTFRREPEEVRSPYLSPEEVFEIVEKGKEAGCKEVLFTFGERPEERYDEALEWLEEHGYSSTVEYLVDLCRRCVEEYDMLPHSNPGVITKREMRKLRRWNASMGLMMEILSERLCEESGPHEHSPGKRPEERLKVLKYAGELKVPFTTGILIGIGETWEERVKTLEEIQRMHERYGHVQEVIVQNFRTKPGIPMEDHPEPTPADLLRTVATARLILPDVPVQVPPNLNRETGQLALLAGANDWGGVSPVTKDYVNPEAPWPEIEELKRLTEDVGFRLRERLPIYPEYVRRGWYHANISEVVERLSDDEGFAR
What is the function of this protein?
Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
What are the official names of this protein?
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, FO synthase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. CofG family.
Protein: KAD_RICRS
Sequence: MIVIFLGPPGAGKGTQGKKIAKKIDLPHIAIGDIFRTIIKTSTSEAELINNYVRQGELIPNEIVNQVIKNFLLSFEYKNGYILDGYPRNLEQAQFFESFIKEKIKIIYFDVSGELLIKRILGRYSCKNCGKIYNRYFLQPKTDNVCDVCGSSTFDYRKDDNEEVIKKRIEVYKTETYPLIDYYKNSGNFYIVNGSKNEQEIAMDIQKILKIN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMO2_CAVPO
Sequence: MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGLWRFKENVEDGRASIYKSVITNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRLFAKKFDLLKYIQFQTTVLTVKKHPDFSSSGQWEVVTQSDGKEQSAVFDAVMVCSGHHILPHIPLKSFPGIERFKGQYFHSRQYKHPAGFEGKRILVIGIGNSASDIASELSKNAAQVFISTRNGSWVMSRISEDGYPWDMVFHTRFKSMLRNILPRTVSKWMMEQQLNRWFNHANYSLEPKNKYLMKEPILNDDLPSRILYGAVKVKSRVTQLTETSALFEDGTVEEDIDVIVFATGYTFSFPFLEESLVKIEHNMVSLYKYMFPPQLEKPTLTCMGLIQPLGSIFPTVELQARWATRVFKGLCHLPSEKTMMEDIIKRNEKRIDLFGESQSQIVQTNYVDYLDELALEIGAKPDLISFLLKDPELAVKLCFGPCNSYQYRLVGPGQWEGARRAILTQKQRILKPLKTRSVKAAPNLSASFLMKILALVAVFVAFFSQLYGF
What is the function of this protein?
Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation.
What are the official names of this protein?
Dimethylaniline monooxygenase [N-oxide-forming] 2, Dimethylaniline oxidase 2, FMO 1B1, Pulmonary flavin-containing monooxygenase 2, FMO 2.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MNMA_ONYPE
Sequence: MTKVVVGLSGGVDSAVAAFLLKKQGYLVEAVFMRNWDSNLNFDIQGNPTLNDICSQELDYKDSLKVSEQLGIKLHRVDFIEEYWQKVFMSFIKAFENNLTPNPDILCNNEIKFRAFIEYATTKLAPQYIAMGHYANIIYETSSDQKLVPRLACAVDQNKDQTYFLSQLTTKQLQNILFPLGNLTKQEVRQIALENNLINATKKDSTGICFIGERNFFQFLSNYLPAQKGDIKTLDGTFLAHHKGVMYYTIGQRKNLGLGDVPSQKPWFVVGKHLPTNTLYVEQGSTHPYLYSDKALIGDIVWRGKKTNLHLQAKMRYRQPNQDVILTWLDQNNLEIHYPQTIKAVTPGQICAFYDKNICCGAGVIKEVYFQGTKRLYT
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSD_PSEPF
Sequence: MVDKLTHLKQLEAESIHIIREVAAEFDNPVMLYSIGKDSAVMLHLARKAFFPGKLPFPVMHVDTRWKFQEMYKFRDKMVEELGLDLITHINPDGVAQNINPFTHGSAKHTDIMKTEGLKQALDKHGFDAAFGGARRDEEKSRAKERVYSFRDSKHRWDPKNQRPELWNVYNGKVNKGESIRVFPLSNWTELDIWQYIYLEGIPIVPLYFAAEREVIEKNGTLIMIDDERILEHLSDEDKARIVKKKVRFRTLGCYPLTGAVESEAESLTDIIQEMLLTRTSERQGRVIDHDGAGSMEDKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: SBCD_BACSU
Sequence: MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIVMAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENGIHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIRQAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVALGHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGKPLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRPVFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK
What is the function of this protein?
SbcCD cleaves DNA hairpin structures.  These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions.  The complex acts as a 3'->5' double strand exonuclease that can open hairpins.  It also has a 5' single-strand endonuclease activity (By similarity).
What are the official names of this protein?
Nuclease SbcCD subunit D.
What is the protein family that this protein belongs to?
Belongs to the SbcD family.