PharMolix/UniProtQA huggingface dataset:
Protein: RPOB_STRT1
Sequence: MAGHDVQYGKHRTRRSFSRIKEVLGLPNLIEIQTDSFKEFLDTGLKEVFEDVLPISNFTDTMELEFVGYELKEPKYTLEEARIHDASYSAPIFVTFRLINKETGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVIPNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIVDIFGDSELVRNTIEKDIHKNPADSRTDEALKEIYERLRPGEPKTADSSRSLLVARFFDPRRYDLAAVGRYKLNKKLNIKTRLLGQTIAENLVDPETGEILVEAGTEMTRDVIDSIAEHLDGDLNKFVYTPNDYAVVTEPVVLQKFKVVAPNDPDRVVTIVGNANPDDKVRALTTADILAEMSYFLNLAEGIGKVDDIDHLGNRRVRAVGELLANQFRIGLARMERNVRERMSVQDNEALTPQQIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSTYGRLNKYGFIQTPYRKVDRATGKVTNEVVWLTADEEDEYIVAQANSKLNEDGTFAEEIVMGRHQGVNQEYPSHLVDFVDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLIDPKAPFVGTGMEYQAAHDSGAAVIAKHDGKVVYSDADKVEVRREDGSLDVYTIQKFRRSNSGTAYNQRTLVKVGDIVEKGDFIADGPSMEGGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEFESETRDTKLGPEEITRELPNVSEEALKNLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGGDGVVRDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIYIATPVFDGASSEDLWDTVREAGMDSDAKTILYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNILQEILTYKSDDVNGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDYEVELRDLDEGEDDDVMHVDDLEKARVQQAKEAAELEKAKEEALDKTE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: U131A_HCMVM
Sequence: MRLCRVWLSVCLCAVVLGQCQRETAEKNDYYRVPHYWDACSRALPDQTRYKYVEQLVDLTLNYHYDASHGLDNFDVLKRINVTEVSLLISDFRRQNRRGGTNKRTTFNAAGSLAPHARSLEFSVRLFAN
What is the function of this protein?
Plays a role in viral entry into host cells.  Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131.  This complex is required for entry in epithelial, endothelial and myeloid host cells (PubMed:23853586, PubMed:17942555).  Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection (PubMed:30057110).  Contributes to the formation of the complex between UL128, UL130 and gH-gL.
What are the official names of this protein?
Protein UL131A.
What are the subcellular locations of this protein?
Virion membrane. Note=Found as a pentameric complex at the surface of virion envelope.
Protein: CDD_VIBVY
Sequence: MKSRFENALASAPESLSRHLAPIILAADFDASLSTVQFDELLKQTGMTDNQLRVALLPFAAAYSYAPISEFYVGAIVRGLSGTLYFGANMEFDGVQLGQTVHAEQSAISHAWMKGEQGLSDITINFSPCGHCRQFMNELSSAKELKIQLPEREEKKLHDYLPDSFGPSDLGIESALMSQVHHGFATEDDDALMQRAVEAMNRSHAPYTHNLSGVALQTESGRVYLGAYAENAAFNPSLPPLQVALIQLLLAGERFENIQSAALVESHKGKISHLACTQSTLEALNPDIPVSYLSL
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: TRPC_PROMP
Sequence: MEIRRRPPNPTVRVENLEYAVPHREAKAKNILEEIVWYKDTEIKNFKKIVSLEDLIKKLDKLSPPKDFFQSILHSKIKPGVIAEIKKASPSKGVIREDFKPKEIASCYEKSGASCISVLTDKRFFQGSYEILQDVRTATNLPLLCKDFIISAYQIYKARVSGADAILLIAAILSDDDLFYLKKIADNLKMSVLVEVHDGQELERILSLKSFNLIGINNRNLKTFKTDLKTSIRIMSKYSDIFSKHNIVPISESGINNSDDLKTLNSIGIKGVLIGERFMRESDIENSFKKLFNSI
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: RL9_DROME
Sequence: MRTINSNQCVKIPKDIKASVKARVVTITGTRGTLKRSFKHLALDMYMPDKRTLKVEKWFGTKKELAAVRTVCSHIENMIKGVTFGFQYKMRAVYAHFPINCVTSENNTVIEIRNFLGEKYIRRVEMAPGVTVVNSTAQKDELIVEGNDIESVSGSAALIQQSTTVKNKDIRKFLDGLYVSEKTTVVKLES
What are the official names of this protein?
60S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: TGT_HAEDU
Sequence: MMKYELKSTSGMARRGRLTFSRPQGECYVETPAFMPVGTYGTVKGMTPEEVKATGAQILLGNTFHLWLRPGQEIMKMHGDLHDFMQWHGPILTDSGGFQVLSLGKLRKIKEEGVTFQNPISGEKIFLSPEKSMEIQYDLGSDIVMIFDECTPYPATLEYAKKSMEMSLRWAKRSRTRFDELANPRALFGIVQGSTYEELRRESVKGLINIGFDGYAVGGLAVGEPKEEMHRILEFTTPLLPQDKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVSDGVVKIRNAKYKNDTTPLDAECDCYTCKNYTKAYLYHLDKCGEILGARLNTIHNLRYYQRLMAQIRQAIEQDCFDEFVVEFYAKIGKEVPPLHLKSE
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: SYT_GEOKA
Sequence: MPDVIRITFPDGAEKEFPKGTTTEDIAASISPGLKKKAIAGKLNGRFVDLRTPLHEDGELVIITQDMPEALDILRHSTAHLMAQAIKRLYGNVKLGVGPVIENGFYYDIDMEHKLTPDDLPKIEAEMRKIVKENLDIVRKEVSREEAIRLYEEIGDELKLELIADIPEGEPISIYEQGEFFDLCRGVHVPSTGKIKEFKLLSISGAYWRGDSNNKMLQRIYGTAFFKKEDLDRYLRLLEEAKERDHRKLGKELELFTTSQQVGQGLPLWLPKGATIRRIIERYIVDKEVALGYDHVYTPVLGSVELYKTSGHWDHYKENMFPPMEMDNEELVLRPMNCPHHMMIYKSKLHSYRELPIRIAELGTMHRYEMSGALTGLQRVRGMTLNDAHIFVRPDQIKDEFKRVVNLILEVYKDFGIEEYSFRLSYRDPHDKEKYYDDDEMWEKAQRMLREAMDELGLDYYEAEGEAAFYGPKLDVQVRTALGKDETLSTVQLDFLLPERFDLTYIGEDGKPHRPVVIHRGVVSTMERFVAFLIEEYKGAFPTWLAPVQVKVIPVSPEAHLDYAYDVQRTLKERGFRVEVDERDEKIGYKIREAQMQKIPYMLVVGDKEVSERAVNVRRYGEKESRTMGLDEFMALLADDVREKRTRLGKAQ
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLA1_SCLS1
Sequence: MGFLGVYSAVYDYVPAGEGELTIKEGDILYVLEKSTEDDWWKAKKKASAEDEDEPVGLIPNNYIQEAAPSGKARALYDYTRQTDEELSFTEDAQLEVFDTSDPDWILVGFEGEYGFVPANYIELSEEEQHKEAPAPSLPSRPRPASVPVEEEAPAAPQSPLSPQPAETPVATPAAAIAGILKQRQASAPAARAPPEFTPEASDEEPPTPTLPARPVSQVSVPQPTRGQEHDREREPARRYSPRLPASPVVTASPPHNRVSFSTMGVVNDVDEHKAARAPGGFHMYNISEMVHVMGKKKKMPTTLGINIATGTILIAPEQARDGPEQTWTAEKMTHYSLEGKHVFMELVRPSKSIDFHAGAKDTATEIVSALGELAGAARAEGLREVIAAGSGSGQKRGQVLYDFVAQGDDEVDVNVGDEVVIIDDVKSEEWWMVRRVKNAKEGVVPSSYIEIMGAIQSASSAGINAGRSTVEQNRLEEARLAREALKTAKKDEVEVGPGMRLPERGSSLFARDNGNQSGEQKRRESVRESGQSRSSKSKPDPAKVRTWTDRSKSFSVEAQFLALKDGKINLHKMNGVKIAVPVVKMSVEDLEYVERMTGISLDEDKPLSDIKKQQKSRAAERDSSNGASPAPGPSASMGAGASIQTPEYDWFQFFLSCDVNVGLCERYAQAFKRDSMDESVLPDIDATVLRNLGIREGDIIKIIRFLDKKYMRKDGKRNVSFGGEDEGEAGLFSGPGGALKNNTRKGRPAPAVQTNDVVDANAFSQNGTEKSSPQGVATPLANAPTPAEKDVKREGFDDDAWDVKPSKQETTSSPPAQSIPAAAPQQPVITGSMQELSLLSTPLEPVKAQPTAQASPQPQAPPAVTPSIFAGIGNQQTGVPQPQPLPSGPLLPANLARQRPAPPQMTANSTLIPPLPPSRPLSAPQAASAYAPPPLQAQATGYGAFQPQIAPPGQSLHDLNQQRMQQQQQQQMQQQQFMLQQQQQAGMMQQPTGFNQFNPGVPNNFQQFPMQTGNPQQPFIPNQTGTPFANPPAQPFQPQPLQAQPTGFQSAFPPGQQYPQPTGVNSYLPPALQPQPTGMMNGANGFNQNFTPPPIPPMPQQQPAPMLPQATGPAPPVRFGVNGTNNIAPQPTGRRANLAQATPQNPFGF
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein sla1.
What is the protein family that this protein belongs to?
Belongs to the SLA1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: TXD11_BOVIN
Sequence: MSECGGRGGGGGSSSSSDDAEDEGGGGGPAGSGSLSPAPAASSEGRLRRGLRGASLMARRRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSSRSPVLDLFQGQLDYAEHIRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKDYLGTVRFGVITNKHLAKLVSLVHSGSVYLHRHFNTSLVFPREVINYTAENICKWALENRETLVRWLWPHGGKSLLLNNELKKGPALFVFIPFNPLAESHPLIDEITEVALEYNNCHGDQVVERLLQHLRRVDAPAFKSLAPDPPARLPDPPLITASPCCNTVVLPRWHSISRTHNVCELCVNQTAGGLRPSSVSMPQCSFFEMAAALDSFYLKEQTFYHVVSDSIECSNFLSFYSPFSYYTACCRTINRGVAGFIDSEQGVFETPPVAFSSLEKKCEVESPGSVPHIEENRYLFPELETSSSSFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSAARVKEFATIVDVKEESHYILDPKQALMKFTLESFIQNFSVLYSPLKRHLIGSDSTQFTSQRLITEVTTDTFWEVVLQKQDVLLLYYAQWCGFCPALNHVFIQLARLLPSDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPEDLPITLPNLLRFILHHSDPASDPRNLAGPPTAECLQNEAVLQQGHIAHLEREIRKLRAEIGTLQRAQVQVEARLASARRDEHRLLRQQHTLERQHDLLRLHSEQLQALYEHKTRELDEVARKLQELADASETLLTENTWLKILVATMEQRLEGRDGADDRVPPSKARSEHPEPPGAPRLPASTPLPANISSTLASEGSPENRTD
What is the function of this protein?
May act as a redox regulator involved in DUOX proteins folding.  The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system.  It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (By similarity).
What are the official names of this protein?
Thioredoxin domain-containing protein 11.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: FIXP_RHIEC
Sequence: MSQKHIDELSGVETTGHEWDGIQELNNPMPRWWIWTFYVTILWAIGYAIAYPAIPMITSATNGYLGYSTRAELQQDLNLAKSSQTEFHDLIAAKTVEEIDADPALRKFAIAGGASAFKVNCAPCHGSGASGGPGFPNLNDDDWLWGGDLNAIQATISHGIRFDGDTDSHSSEMPPFAGVLEPIQMKQVAAFVWGLTNTPSDVGLAAAGKQVFFDNCAPCHGEDAKGKVEMGAPDLADAIWLKSRGEDAILRQVASPKHGVMPAWAARLGDTTVNELTIFVHALGGGT
What is the function of this protein?
C-type cytochrome.  Part of the cbb3-type cytochrome c oxidase complex.  FixP subunit is required for transferring electrons from donor cytochrome c via its heme groups to FixO subunit.  From there, electrons are shuttled to the catalytic binuclear center of FixN subunit where oxygen reduction takes place.  The complex also functions as a proton pump.
What are the official names of this protein?
Cbb3-type cytochrome c oxidase subunit FixP, Cbb3-Cox subunit FixP, C-type cytochrome FixP, Cyt c(FixP), Cytochrome c oxidase subunit III.
What is the protein family that this protein belongs to?
Belongs to the CcoP / FixP family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: KHSE_ACICJ
Sequence: MAVYTEVTDDALAAFLEGYDIGRMVAFRGIAEGVENSNYSLRTTEGDFILTLYERRVDPADLPWFLGLMEHLAAKSLPCPLPVRARDGANLNPLAGRIAAITTFLPGVWPRRPTVAHCGPLGAAMARMHLAGEDYAPTRANALGPQGWPPLLARCGDSGDAVRPGLTGEVRTALDATLAAWPGALPRGHIHADLFPDNVFFLDHAISGLIDFYFAATDLYAYDIAVCLNAWCFEPDFSFNITKSRALLRGYQAVRPLSAAETEALPVLCRGAAIRFLLTRLYDWINTPDDALVTRKDPLDYYWRLRFHLQAGSAADYGV
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: RL13_MYCGE
Sequence: MQKTSMLTKEEAIKNRKWYLVDASGLVLGKLAVKAANLIRGKNKANFTPNQDCGDHLIIINSDQVVLTGNKKDNEFWYHHSQYMGGIKKTSGRDMINKNSDKLVFNAVKGMLPDNRLSRRLITKVHVFKNDKHNMEAQKPTLLNWS
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PFKA_BACMK
Sequence: MKRIGVLTSGGDSPGMNAAIRAVVRKAIFHDIEVYGIYHGYAGLISGHIEKLELGSVGDIIHRGGTKLYTARCPEFKDPEVRLKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEQGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTYVIEVMGRHAGDIALWAGLADGAETILIPEEKYDMEDVIARLKRGSERGKKHSIIVVAEGVGSAIDIGKHIEEATSFDTRVTVLGHVQRGGSPSAQDRVLASRLGARAVELLIAGNGGRCVGIQNNKLVDHDIIEALAQKHTIDKDMYQLSKELSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_MYCA9
Sequence: MTTGFSVAVAGASGYAGGEILRLLLAHPAYTAGRLRIGVLTAGSNAGSSLIEHHPNLTPLADHKLQPTDSTLLRGHDVVFLALPHGSSAKIAEELGPQTLIIDCGADFRLTDAAAWERYYGSKHAGSWPYGLPELPGGRDALHGTKRVAVPGCYPTAALLALSPAVTAGLVEPSVTVVAVSGTTGAGRAPKAELLASEVMGSARAYNIAGAHRHTPEIAQGLKHPSGGPVSVSFTPVLIPMPRGILATCTAPTTASLSEIRDAYEDAYRTEEFIHVLPEGHLPTTKAVVGSNAVHIGLAVDPDAGVLVAVAAIDNLVKGTAGAAIQSMNLALGWPEADGLSIVGVAP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_STAAB
Sequence: MTHIQLDFSKTLEFFGEHELKQQQEIVKSIHKTIHEGTGAGSDFLGWVDLPVDYDKEEFSRIVEASKRIKENSDVLVVIGIGGSYLGARAAIEMLTSSFRNSNEYPEIVFVGNHLSSTYTKELVDYLADKDFSVNVISKSGTTTEPAVAFRLFKQLVEERYGKEEAQKRIFATTDKEKGALKQLATNEGYETFIVPDDVGGRYSVLTAVGLLPIATAGINIEAMMIGAAKAREELSSDKLEENIAYQYATIRNILYAKGYTTEMLINYEPSMQYFNEWWKQLFGESEGKDFKGIYPSSANYTTDLHSLGQYVQEGRRFLFETVVKVNHPKYDITIEKDSDDLDGLNYLAGKTIDEVNTKAFEGTLLAHTDGGVPNMIVNIPQLDEETFGYVVYFFELACAMSGYQLGVNPFNQPGVEAYKQNMFALLGKPGFEDLKKELEERL
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_STRP7
Sequence: MSTIEEQLKALREETLASLKQITAGNEKEMQDLRVSVLGKKGSLTEILKGMKDVSAEMRPIIGKHVNEARDVLTAAFEETAKLLEEKKVAAQLASESIDVTLPGRPVATGHRHVLTQTSEEIEDIFIGMGYQVVDGFEVEQDYYNFERMNLPKDHPARDMQDTFYITEEILLRTHTSPVQARAMDAHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLVVGKNISMADLQGTLQLIVQKMFGEERQIRLRPSYFPFTEPSVEVDVSCFKCGGEGCNVCKKTGWIEIMGAGMVHPRVLEMSGIDATVYSGFAFGLGQERVAMLRYGINDIRGFYQGDVRFSEQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_NOVAD
Sequence: MPRTSALSGASSLFDLDGPMSARRIVVAMSGGVDSSVVAGLAAATGAEVIGVTLQLYDYGAATGRKGACCAGDDIRDARAVADRLGIAHYVFDHESSFREEVVERFADDYLSGRTPIPCVRCNMGPKFTDLLAMARELGADCLATGHYVRRVMGPAGPELHRAVDPARDQSYFLYGTTEEQLAFLRFPLGGLPKTETRLIAEELGLAVAAKPDSQDICFVPDGDYARVVRSVRPEGDAPGEIVHAATGEVLGTHRGIIHYTVGQRRGLEIGGQPEPLYVIGLDAPSRRVLVGPRPMLAVASATIVETNRIGPLPDAPLTAKVRSLARPVPVVLEGSFGEGASARIRFSQPEYGVAPGQAAVLYAGDRVVGGGWIDSTERWEIEG
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_ACIF5
Sequence: MSAKTLYDKLWESHVVHTEQDGGVLLYIDRQLLHEVTSPQAFSGLRAAGRKAWRIDANIATADHNVPTTDRAAGIADATSRLQVDTLDRNCAEFGIEEFGMHDKRQGIVHVIAPEQGLTLPGMTVVCGDSHTATHGALGALAFGIGTTEVEHVLATQCLWARKSRSMRIWVEGELGNGVTAKDLVLAIIGRIGTAGGTGYAIEFAGPAVHALSVEGRMTLCNMAIEAGARSGMVGVDAVTIDYLRGRPYAPVGKIWDQAVAVWGELHSDPDAQFDAEIRLEATDVAPQVTWGTSPEMVVDISARVPDPALEKDPVRRKGWSDALAYMDLAAATPISSIALDKVFIGSCTNARIEDLRAAAAVARGHHKAASVKAVLVVPGSGLVKAQAEAEGLDRIFRDAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQGAGGRTHLVSPAMAAAAAIAGHFVDVRDWIMH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: APLF_MOUSE
Sequence: MPSDFFLQPLDGGPRVPVGPGQTVIGRGPLLGITDKRVSRRHAILEVVDSQLRIKPIHRNPCFYQSSEKSQHSPMETQVWSQLHPGDSFSLLLDKYAFRVFSAESEVEMECTLRNSQMLDEDDILSEMQKSPVVNLPDKTTGASQLQGSPEITKTKCPTIDPMSSSGECRAFSEHQPRPTQRKRILPAWMLAESLSDQSLSTPAEGGDKDVIQRSGKAGTCEDRTPGNTSWHGKKRLSPSGNSKSVSAEQDPGKKCRKADQEGPGVSSENVPESSSSNIVKDPDVDIVKTNKQKDGILIEELGEVSKHKAATKPTTNEEGESCARVQSKSPPEKSQGCHPESSSAPSSPDALHTDTADPVLGCSEESKVRRTACMYGANCYRRNPLHFQHFSHPGDSDYGEVHGTDEGVIGDRPECPYGASCYRKNPQHKMEYRHSALPARVALDEDDDDVGQPSDDEDEEDYEPTDEDSDWHPGKDDEEQEDVDELLKEAKSSLHLKH
What is the function of this protein?
Histone chaperone involved in single-strand and double-strand DNA break repair (By similarity).  Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (By similarity).  Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (PubMed:27875275).  Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro (By similarity).  Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (By similarity).  Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721).  Also acts as a negative regulator of cell pluripotency by promoting histone exchange (PubMed:27875275).  Required for the embryo implantation during the epithelial to mesenchymal transition in females (PubMed:33277378).
What are the official names of this protein?
Aprataxin and PNK-like factor, Apurinic-apyrimidinic endonuclease APLF.
What is the protein family that this protein belongs to?
Belongs to the APLF family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers.
Protein: RS20_BACAA
Sequence: MANIKSAIKRAKLSEERRAHNASIKSDMRSAVKTVEALVTNNDLENAKEAFKTASKKLDKAARKGLIHQNAAARQKSRLAKQVNA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RL7_BORBU
Sequence: MALNKEDILTWLEGAKTMEVVDLVTAIEEKFGVTAAVAAGVGGAVSVGSADSEEQTEFDVILMSFGDSKINVIKEVRAITGLGLGEAKALVEAAPKAIKEGLSKSDAEELKKKLEAVGAKVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: DER_PSEA8
Sequence: MVPVIALVGRPNVGKSTLFNRLTKSRDAIVAEYAGLTRDRQYGEARWQGRTYIVIDTGGISGDEEGIDAKMAEQSLQAIEEADAVLFLVDSRAGMTAADQMIAEHLRKRNKRSFLIANKVDTIDPDLARAEFSPLGLGDALPIAAAHGRGINHMLQEALGIFPKDNVEEEGEGEPASEEVAEGEEPTRIPGPSEKDGIKIAIIGRPNVGKSTLVNRMLGEERVIVYDQAGTTRDSIYIPFERNEEKYTLIDTAGVRRRGKIFEAVEKFSVVKTLQAIQDANVVIFVMDAREGVVEHDLNLLGFVLETGRALVIALNKWDGMEAAERDYVKTELERRLLFVDFADIHFISALHGTGVGHLYKSVQESFRSAVTRWPTSRLTSILEDAVQVHQPPMVNGRRIKLRYAHLGGANPPLIVIHGNQVDAVPKAYTRYLEKTYRRVLKLVGTPIRIEYKGGENPYEGKKNSLTARQVNKKRRLMSHHKKAEKKKKDKRR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: TTCA_ECOBW
Sequence: MQENQQITKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHVLPEYLEKLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIQRFADAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVNGGDLAFDREEIPLQPACWQPEEDENQLDELRLNVVEVK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCU4_CAEEL
Sequence: MAITCMDIPKFLFALLLPPVGVFLEKGCTHHLAICILLTILGYIPGIIYACYIILAY
What are the official names of this protein?
UPF0057 membrane protein T23F2.4.
What is the protein family that this protein belongs to?
Belongs to the UPF0057 (PMP3) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KAD_ECO24
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAMKEAGINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYHQMTAPLIGYYSKEAEAGNTKYAKVDGTKPVAEVRADLEKILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCR_SALG2
Sequence: MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRGPGGGYLLGKDAGSIAVGEVISAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGFLNNITLGELVNNQEVLDVSGRQHTHDAPRASGRAQDAIDVKLRA
What is the function of this protein?
Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.
What are the official names of this protein?
HTH-type transcriptional regulator IscR.