PharMolix/UniProtQA huggingface dataset:
Protein: PPN1_NEUCR
Sequence: MSLSRCILGLACLWHGVIASPLGAVPSNIPIATDLQTAAETVAQPIANSARKLHGKFLHITDLHPDQFYKPHSSTDEADACHRGKGPAGVYGAEVSDCDSPFALINATFDWIAANVKDDIDFVIWTGDTARHDSDEGVPRNADQVLGTNRWIADKMAELFSDSTGRHLEIPIVPTLGNNDILPHNILLPGPNSWLQHYTHIWRRFVPEAQRHSFQFGGWFYVEVIPNRLAIFSLNTLYFFDRNAGTDGCASPSEPGYKQMEWLRIQLHIMRERGMKAILMGHVPPARTDSKKLWDENCWQKYSLWLRQYRDVVVSGVFGHMNIDHFFIHDERDINVGQLAGLADNSIDIREAMDDELSVTGAADYLRELRQNWAKLQPPPTDSKNSGQLKKGKKGRKGKKKKPDVWGERYSLSLVSPSIVPNYYPALRIVEYNISGLEDTPVWRDAAKDAMSIELEQNDRQKHLDLKRQHPSHMEDDDEIDAQKKKGKKHKGGDSKPKKPDFLIPHPPAKSSPPGPAYSPQPLTLTGYTQYFANLTHINNITTEASSALLDHDEEEETWVDWLLRWRKGRHGNRKPIHPKPDPREFQFEVEYSTFNDKLYKLRDLTVKNYVELAYRISKQPKKGKAKSIDVSYESAAEEEEEEEEEEEEDLFEEVEETDEEEEQEDDDLSDGEEVDDDSDEDELETETFKKHDKKKHKKKKGKKRQNKVWMHFLTHAFVSTVEKEDLKKFT
What is the function of this protein?
Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
What are the official names of this protein?
Endopolyphosphatase.
What is the protein family that this protein belongs to?
Belongs to the endopolyphosphatase PPN1 family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein.
Protein: ECCC3_MYCTU
Sequence: MSRLIFEARRRLAPPSSHQGTIIIEAPPELPRVIPPSLLRRALPYLIGILIVGMIVALVATGMRVISPQTLFFPFVLLLAATALYRGNDKKMRTEEVDAERADYLRYLSVVRDNIRAQAAEQRASALWSHPDPTALASVPGSRRQWERDPHDPDFLVLRAGRHTVPLATTLRVNDTADEIDLEPVSHSALRSLLDTQRSIGDVPTGIDLTKVSPITVLGERAQVRAVLRAWIAQAVTWHDPTVLGVALAARDLEGRDWNWLKWLPHVDIPGRLDALGPARNLSTDPDELIALLGPVLADRPAFTGQPTDALRHLLIVVDDPDYDLGASPLAVGRAGVTVVHCSASAPHREQYSDPEKPILRVAHGAIERWQTGGWQPYIDAADQFSADEAAHLARRLSRWDSNPTHAGLRSAATRGASFTTLLGIEDASRLDVPALWAPRRRDEELRVPIGVTGTGEPLMFDLKDEAEGGMGPHGLMIGMTGSGKSQTLMSILLSLLTTHSAERLIVIYADFKGEAGADSFRDFPQVVAVISNMAEKKSLADRFADTLRGEVARREMLLREAGRKVQGSAFNSVLEYENAIAAGHSLPPIPTLFVVADEFTLMLADHPEYAELFDYVARKGRSFRIHILFASQTLDVGKIKDIDKNTAYRIGLKVASPSVSRQIIGVEDAYHIESGKEHKGVGFLVPAPGATPIRFRSTYVDGIYEPPQTAKAVVVQSVPEPKLFTAAAVEPDPGTVIADTDEQEPADPPRKLIATIGEQLARYGPRAPQLWLPPLDETIPLSAALARAGVGPRQWRWPLGEIDRPFEMRRDPLVFDARSSAGNMVIHGGPKSGKSTALQTFILSAASLHSPHEVSFYCLDYGGGQLRALQDLAHVGSVASALEPERIRRTFGELEQLLLSRQQREVFRDRGANGSTPDDGFGEVFLVIDNLYGFGRDNTDQFNTRNPLLARVTELVNVGLAYGIHVIITTPSWLEVPLAMRDGLGLRLELRLHDARDSNVRVVGALRRPADAVPHDQPGRGLTMAAEHFLFAAPELDAQTNPVAAINARYPGMAAPPVRLLPTNLAPHAVGELYRGPDQLVIGQREEDLAPVILDLAANPLLMVFGDARSGKTTLLRHIIRTVREHSTADRVAFTVLDRRLHLVDEPLFPDNEYTANIDRIIPAMLGLANLIEARRPPAGMSAAELSRWTFAGHTHYLIIDDVDQVPDSPAMTGPYIGQRPWTPLIGLLAQAGDLGLRVIVTGRATGSAHLLMTSPLLRRFNDLQATTLMLAGNPADSGKIRGERFARLPAGRAILLTDSDSPTYVQLINPLVDAAAVSGETQQKGSQS
What is the function of this protein?
Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.
What are the official names of this protein?
ESX-3 secretion system protein EccC3, ESX conserved component C3, Type VII secretion system protein EccC3, T7SS protein EccC3.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RGS5_BOVIN
Sequence: MCKGLAALPHSCLERAKEIKIKLGILLQKPESAIDLVIPYNEKPEKPAKTQKPSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWMACEDYKKIKSPVKMAETAKKIYEEFIQVEAPKEVNIDHFTKEITVKNLVEPSPSSFDVAQKRIHALMEKDSLPRFVRSEFYQEFIK
What is the function of this protein?
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.  Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).
What are the official names of this protein?
Regulator of G-protein signaling 5, RGS5.
What are the subcellular locations of this protein?
Cytoplasm. Membrane.
Protein: PTH_PHOV8
Sequence: MKYLITGLGNIGEEYRNTRHNIGFTVLDALAKASNLVFTDGRYGATATLSLKGRQLILLKPSTYMNLSGNAVRYWMQKENIPLENVLIVVDDLALPFGTLRLKGKGSDAGHNGLKHIAATLGTQDYARLRFGIGNDFPRGGQIDFVLGHFTDEDLKTMDERVATACDIIKSFCLAGISITMNQYNKK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSN2_RAT
Sequence: MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPDHYACSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVFKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWSTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI
What is the function of this protein?
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).  Requires the other members of the gamma-secretase complex to have a protease activity.  May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.  May function in the cytoplasmic partitioning of proteins.  The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (By similarity).  Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369).
What are the official names of this protein?
Presenilin-2, PS-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: MDH_BRUA2
Sequence: MARNKIALIGSGMIGGTLAHLAGLKELGDVVLFDIAEGTPQGKGLDIAESSPVDGFDAKFTGANDYAAIEGADVVIVTAGVPRKPGMSRDDLLGINLKVMEQVGAGIKKYAPEAFVICITNPLDAMVWALQKFSGLPAHKVVGMAGVLDSARFRYFLSEEFNVSVEDVTVFVLGGHGDSMVPLARYSTVAGIPLPDLVKMGWTSQDKLDKIIQRTRDGGAEIVGLLKTGSAFYAPAASAIQMAESYLKDKKRVLPVAAQLSGQYGVKDMYVGVPTVIGANGVERIIEIDLDKDEKAQFDKSVASVAGLCEACIGIAPSLK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: MDM34_PYRTR
Sequence: MAFNFNWSPLIADTSRARDMLTTALNKSPKPPIIVDDIIVTELNLGTTPPELEILEIGDLAEDRFRGIFKMSYAGDAFLTLKTKVQANPLKTYLSNKPDFASPQPLAAAAGLTIPLQITLSNIRLSGFVILVFSKQKGLTLVFRNDPLESLKVSSTFDSIPFVRDYLQKEIEGQLRVLFMEDLPAIIHRLSLRMLSPEYQEIETEERLEGANDTTAAIDPLASPPEDAVDAFGNPLDEAQISAMSLDSGEIHASFSQKNILRLAALSESQRTLSLFTPGIREAVFRAWAGHPDRAESGAATPALTQGSLSRIQSTFGSLKSGASSVASGSTGNETLSSRPTLASSYSTSAGISLGSGRSRAGGMRKRKKRVVDLRRKDGADSGVSTEANTPLPSTQVSDTSSVIPEEREAEEELATPPTSPPQPGRRFESRRGSLDVGTPKRIPEEPPTFGPLLAPAPLIPNASKAAKSKRTVSPPAHLEDPFVSHTSSRRPPISRNKLRQAQQSTSPLLRSLSFDKVSSLSALCSPPRISSPPNADLMSSSGGILEQAWMQKMAQEIARKVQEEKDKSSGQRRPSHSRTKTAPTGGFWQGEDEVEAPPAYVA
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: RL6_SHIFL
Sequence: MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: IF4A8_TOBAC
Sequence: MARLAPDGAQFDARQYDSKMNDLLAADGKDFFTSYDEVYDSFDAMGLQENLLRGIYAYGFEKPSAIQQRGIVPFCKGLDVIQQAQSGTGKTATFCSGILQQLDYGLVQCQALVLAPTRELAQQIEKVMRALGDYLGVKVHACVGGTSVREDQRILAAGVHVIVGTPGRVFDMLRRQSLRPDYLRMFVLDEADEMLSRGFKDQIYDIFQMLPTKVQVGVFSATMPPEALDITRKFMNKPVRILVKRDELTLEGIKQFYVNVDKEEWKLETLCDLYETLAITQSVIFVNTRRKVDWLTDKMRTRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTQPENYLHRIGRSGRFGRKGVAINFVTTDDERMLFDIQKFYNVIIEELPSNVADLL
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
Eukaryotic initiation factor 4A-8, eIF-4A-8, ATP-dependent RNA helicase eIF4A-8.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
Protein: WIPI4_DANRE
Sequence: MAQQRGVNSLQFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSIALCSMLHRSNLLAVVGGGVNPKFSEISVLIWDDAREVRDPKDKLVLEFTFTKPVLAVRMRHDKIIIILKNRIYVYSFPDNPVKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLSNTKPGTSSAPFTINAHQSEIACLALNQPGSVVASASRKGTLIRLFDTTTRDKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTKLNRRSALARVGKVGPVIGQYVDSQWSLANFTVPAECACICAFGKNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF
What is the function of this protein?
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (By similarity).  Binds phosphatidylinositol 3-phosphate (PtdIns3P) (By similarity).
What are the official names of this protein?
WD repeat domain phosphoinositide-interacting protein 4, WIPI-4, WD repeat-containing protein 45.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure.
Protein: YIHI_SALEP
Sequence: MKKPTSAPRSKAFGKQRRKTREELNQEARDRKRLKKHRGHAPGSRAAGGNSASGGGNQNQQKDPRIGSKTPVPLGVTEKVTQQHKPKSEKPMLSPQAELDLLETDERLDALLERLEAGETLSAEDQAWVDAKLDRIDELMQKLGLSYDDDEEDDEEDEKQEDMMRLLRGGN
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: ERF80_ARATH
Sequence: MAPRQANGRSIAVSEGGGGKTMTMTTMRKEVHFRGVRKRPWGRYAAEIRDPGKKTRVWLGTFDTAEEAARAYDTAAREFRGSKAKTNFPLPGESTTVNDGGENDSYVNRTTVTTAREMTRQRFPFACHRERKVVGGYASAGFFFDPSRAASLRAELSRVCPVRFDPVNIELSIGIRETVKVEPRRELNLDLNLAPPVVDV
What is the function of this protein?
Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.  Transcription factor that binds to the GCC-box pathogenesis-related promoter element.  Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity).
What are the official names of this protein?
Ethylene-responsive transcription factor 9, AtERF9, Ethylene-responsive element-binding factor 9, EREBP-9.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: VIRA_AGRT9
Sequence: MNGRYSPTRQDFKTGAKPWSILALIVAAMIFAFMAVASWQDNATTQAILSQLRSINADSASLQRDVLRAHTGTVANYRPIISRLGALRKNLEDLKQLFRQSHIVSESNAAQLLRQLEVSLNSADAAVAAFGAQNVRLQDSLASFTRALSSLPGKASTDQTLEKPTELASMMLQFLRQPSPAISFEISLELERLQKQRGLDEAPVRILAREGPIILSLLPQVKDLVNMIQTSDTAEIAEMLQRECLEVYSLKNVEERSARIFLGSASVGLCLYIITLVYRLRKKTDWLARRLDYEELIKEIGVCFEGEAATTSSAQAALRIIQRFFDADTCALALVDHDRRWAVETFGAKHPKPVWDDSVLREIVSRTKADERATVFRIISSKKIVHLPLEIPGLSILLAHKSTDKLIAVCSLGYQSYRPRPCQGEIQLLELATACLCHYIDVRRKQTQCDVLARRLEHAQRLEAVGTLAGGIAHEFNNILGSILGHAELAQNSVSRTSVTRRYIDYIISSGDRAMLIIDQILTLSRKQERMIKPFSVSELVTEIAPLLRMALPPNIELSFRFDQMQSVIEGSPLELQQVLINICKNASQAMTANGQIDIIISQAFLPVKKILAHGVMPPGDYVLLSISDNGGGIPEAVLPHIFEPFFTTRARNGGTGLGLASVHGHISAFAGYIDVSSTVGHGTRFDIYLPPSSKEPVNPDSFFGRNKAPRGNGEIVALVEPDDLLREAYEDKIAALGYEPVGFRTFNEIRDWISKGNEADLVMVDQASLPEDQSPNSVDLVLKTASIIIGGNDLKMTLSREDVTRDLYLPKPISSRTMAHAILTKIKT
What is the function of this protein?
Activates VirG, by phosphorylating it, in the presence of acetosyringone or hydroxysyringone.
What are the official names of this protein?
Wide host range VirA protein, WHR VirA.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: F3GT2_ACTCC
Sequence: MSDHSKALHVAVLAFPFGSHAAPLLALVCRLATSNPTVRFSFLSTAQSNTHTFPSTRTNEFDNVRPYNVWDGVPEGHQISGNPHVGTGFFLKALPHNFKAGMAKAEEESGATINCLLTDAFFWFAGDLAEEMGVPWVPYWTAGACSLSAHVNTDVIRITLGSTRTTQNTNQTLNFIPGLSAVHMNDLPGGVLHGDLESPFAQMLHKMGLNLPRATAVVLNSFEELEPAITTDLKLRLQKVLHVGPPSLSSSPTSSLDESGCLLWLDKHEAASVAYISFGTIITPPPNELLALAEALRASKIPFLWSLRDHSRPIFPEGFLENVLAFGKVVSWAPQSQVLAHPSIGVFVTHCGWNSILESITGGVPMICRPFFGDQTLNSRMVQDAWRIGVRLDGGVFTKSSMMSAVELIFSREEGKKLRENIILLKQKATDAVGASGSSTENFNVLLEVIKTCKHPKS
What is the function of this protein?
Catalyzes the glucosylation of quercetin (PubMed:21175894).  Preferentially uses UDP-glucose as sugar donor, but is also able to use UDP-gal and UDP-xyl (PubMed:21175894).  Is probably not required for the accumulation of anthocyanin in red-fleshed kiwifruit varieties (PubMed:21175894).
What are the official names of this protein?
Flavonol 3-O-glucosyltransferase F3GT2, Flavonoid 3-O-glycosyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: HRCA_PARP8
Sequence: MLDPRAQTLLKTLIERYIAEGQPVGSRTLSRYSGLELSPATIRNVMSDLEELGLVISPHTSAGRIPTPRGYRLFVDTMLTVEPSADEDAVMRAVKTTLQPGEPQKVVAAAASVLSNLSQFAGVILTPRRSHVFKQIEFLRLSDKRILLIIVTPEGDVQNRIMATQRDFTPSQLVEASNYINAHFAGLSFDEVRRRLREEIDELRGDMTTLMHAAVTASTDVTDTGETVLISGERKLLEVADLSSDMARLRKLFDVFDQKTSLLQLLDVSSHAQGVQIFIGGESNLVPIEEMSVVTAPYEVNGKIVGTLGVIGPTRMAYNRVIPIVDITARLLSMTLSQQ
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: RL5_MAGSA
Sequence: MARLRKHYDTVVKPALQKEFNYANPMQVPKLQKIVINMGVGEAAQDSKKIESALAELTLISGQKPVSTKAKMSIAQFKLREGQVVGCKVTLRAERMYEFLDRLINIALPRVRDFRGVPGKSFDGRGNYSLGLKEQIVFPEIDYDKVETIRGMDIIFVTTAKSNEEAKALLKGFDMPFVA
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: TILS_ALKCK
Sequence: MEARVEQFIENNRLFGMETNVLVAVSGGPDSMALLAIMANLREKWKLNLFGVHVNHRLRGEESNKDAELVQSFSARLGVPCNVKDVDVAAFKAEHHVGTQQAARALRYQVFQGEMERVHATVLLTAHHGDDEVETAFMKLTRGTTPLTKLGIAATRPFANGVLARPLLEETKRSIVAYCHEKAIPYRIDQSNFSDAYTRNRFRMNMAPYLVEENPHIHKHIGRFDRWQEEDNHYLMEQAKAHLDQILTKKSEKSIELEIQALCLAPFPLQRRMIHLILNYLHLNVYGVNDMRVFPDAIEQIQAFLQTSAPSAQLDLPGRVQVKRSYGTCLFTTAPFIETKAYCHLLSIPGKVDTPLGVIRADTREELLELEHTDAVSFQVSQVAFPLYIRNRKPGDKLSPSGMSGSKKVNRLFIDRKVDRAKRDAWPLLVDANDSILWVPSLQTSRILTRSANVQGELLHVTFSQHKWP
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EDEM1_HUMAN
Sequence: MQWRALVLGLVLLRLGLHGVLWLVFGLGPSMGFYQRFPLSFGFQRLRSPDGPASPTSGPVGRPGGVSGPSWLQPPGTGAAQSPRKAPRRPGPGMCGPANWGYVLGGRGRGPDEYEKRYSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPDTNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFNAAYQSIQNYLRRGREACNEGEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYNWQLQAPDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKCGYATLHHVIDKSTEDRMESFFLSETCKYLYLLFDEDNPVHKSGTRYMFTTEGHIVSVDEHLRELPWKEFFSEEGGQDQGGKSVHRPKPHELKVINSSSNCNRVPDERRYSLPLKSIYMRQIDQMVGLI
What is the function of this protein?
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.  It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L.  It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.
What are the official names of this protein?
ER degradation-enhancing alpha-mannosidase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: ASR1_YEAST
Sequence: MEECPICLADDQEGEQFGCLNVCGHKFHLNCIREWHKYSINLKCPICRVESTHLEVGEGQHALSINLKMGFMIKNAIDYVGAETTNERNEDDTGEQDQEIEFLSERLRGTLVMDTIKIIQCSICGDTDVSRLSLYCQDCEAIYHETCLRGLACEVGDRNTWQECTDCRSNALLELRMGAISSQLASYDSRNSMIFAGELRDKHSVKTQQMYEQIRNAKHKIQMHVRRALDRYPLPLLRFKDAYKHVNKQVSRKLYRLSDNKYLPDQYDYDSLARTGVHTELLIYCHDE
What is the function of this protein?
Required for tolerance to alcohol.
What are the official names of this protein?
Alcohol-sensitive RING finger protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Accumulates in the nucleus specifically upon alcohol stress. Shuttles between the nucleus and the cytoplasm in a XPO1-dependent manner.
Protein: GUNB_FUSOX
Sequence: MAYKLILAAFAATALAAPVEERQSCSNGVWAQCGGQNWSGTPCCTSGNKCVKLNDFYSQCQPGSAEPSSTAAGPSSTTATKTTATGGSSTTAGGSVTSAPPAASDNPYAGVDLWANNYYRSEVMNLAVPKLSGAKATAAAKVADVPSFQWMDTYDHISLMEDTLADIRKANKAGGKYAGQFVVYDLPNRDCAAAASNGEYSLDKDGANKYKAYIAKIKGILQNYSDTKVILVIEPDSLANLVTNLNVDKCAKAESAYKELTVYAIKELNLPNVSMYLDAGHGGWLGWPANIGPAAKLYAQIYKDAGKPSRVRGLVTNVSNYNGWKLSTKPDYTESNPNYDEQRYINAFAPLLAQEGWSNVKFIVDQGRSGKQPTGQKAQGDWCNAKGTGFGLRPSTNTGDALADAFVWVKPGGESDGTSDTSAARYDYHCGLDDALKPAPEAGTWFQAYFEQLLDNANPSFL
What are the official names of this protein?
Putative endoglucanase type B, Cellulase, Endo-1,4-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 6 (cellulase B) family.
Protein: H2A_CHAGB
Sequence: MTGGGKSGGKASGSKNAQSRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKTGKTGKTLSQEL
What is the function of this protein?
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CYSC_CLOAB
Sequence: MNNKKSTNVVWQETKIKRQNREKMLKQKGAVLWFTGLSGSGKSTVASALEKKLYEMGYLTYLLDGDNLRYGLNSDLGFKSEDRTENIRRVSEVAKLFADAGIITITTFISPFIEDRNNARKLLGKDFVEVYIDCPIEVCEKRDPKGIYKKARNGEIKNFTGIDSPYEKPEKPEITVETYKDTEEKCVDNIIEYLKQHKIL
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: WDR37_XENTR
Sequence: MPTESGSWAAARQTKQKRKSHSLSIKRTNSSEQDRPGLQREMLEGQDSKLPSSVRNTLLELFGQIEREFENLYLENLELRREIDTLNDRLAVEGQAIDGAELSKGQMKTKASHSTSQLSQKLKTTYKASTSKIVSSFKTTTSRAICQLVKDYVGHRDGLWDVSVTRTQPVVLGTASADHTALLWSIETGKCLIKYVGHAGSVNSIKFHPTEQIALTASGDQTAHIWRYMVQLPTPQPTADTSISGEEEVDFSDKDENDGDGDASSDCPTVRVPLTALKSHQGVVIAADWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRISVSVGQRIIALPHDNRQVRLFDMSGVRLARLPRSNRQGHRRMVCCCAWSEDHPTCNLFTCGFDRQAIGWNINIPALLQEK
What are the official names of this protein?
WD repeat-containing protein 37.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: AHA1_YEAST
Sequence: MVVNNPNNWHWVDKNCIGWAKEYFKQKLVGVEAGSVKDKKYAKIKSVSSIEGDCEVNQRKGKVISLFDLKITVLIEGHVDSKDGSALPFEGSINVPEVAFDSEASSYQFDISIFKETSELSEAKPLIRSELLPKLRQIFQQFGKDLLATHGNDIQVPESQVKSNYTRGNQKSSFTEIKDSASKPKKNALPSSTSTSAPVSSTNKVPQNGSGNSTSIYLEPTFNVPSSELYETFLDKQRILAWTRSAQFFNSGPKLETKEKFELFGGNVISELVSCEKDKKLVFHWKLKDWSAPFNSTIEMTFHESQEFHETKLQVKWTGIPVGEEDRVRANFEEYYVRSIKLTFGFGAVL
What is the function of this protein?
Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity.  Binding to HSP82 promotes a conformational switch in the catalytic loop of HSP82, facilitating the interaction of the catalytic 'Arg-380' with ATP in the N-terminal nucleotide-binding domain.  Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting.
What are the official names of this protein?
Hsp90 co-chaperone AHA1, Activator of Hsp90 ATPase protein 1.
What is the protein family that this protein belongs to?
Belongs to the AHA1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPB2_THEMA
Sequence: MRIVVNLKPEEIPKHWYNVLADLPFKLDPPLDPETKQPISPEKLSVIFPMSLIEQEVSEERFIEIPEPVLKEYAVYRPTPLIRATFLEEYLQTPARIYYKYEGVSPTGSHKPNTAIAQAYYNKIEGVKRLVTETGAGQWGSALSYAGAKFGLEVKVFMVKVSYQQKPMRKYMMNLFGGKVTPSPSEETNFGRKILSEDPDNPGSLGIAISEALEVAVSDPNTKYSLGSVLNHVLLHQTVIGLEIKKQLELIGEKPDILLGCHGGGSNFGGTILPFVPDKLSGRDIRFVACEPAACPSLTKGNYDYDFGDTAGLTPLLKMYTLGKDFIPPKIHAGGLRYHGSAPIIARLVKEGLVEAQAFDQDETFEAAKIFAKLEGIIPAPESAHAIAGAIREAKKAKEEGKERVIVFTLSGHGLLDLTAYV
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain 2.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.