PharMolix/UniProtQA huggingface dataset:
Protein: GRA14_GIBZE
Sequence: MEKSPDLVLIQATSIRSSNLPLFLIHGDDGDISKYFLLDPLDRNVYGIRNRCCDSAKAWPGGIPEMAKAYLDLIRAVKPRGEILLGGWSLGGLISLEIALVIARNQFSPLNVEGIIMIHTIFPSHQLRIEQVSKRPDSNADSHNGVGPCMIHNQRMIATWRPSPWPIRHIYTGLSDFESESPIVPQEPERISEIRYRQPPPPTILLRARHPASLVARCNNAGYCADTHCHRPMLGWESYREDFIVSIIDIEGNCFSIFDNNYVEGYISTDTLLDLHPICNRIAVVQFDAPVRLYLGLLVITLIDNKNNVMLFHYFTVRVNSDICIISIDLNLPSTGPISQTVNSKLAALASTTQGLNVPVLDLIFPTAAYTQLMSDTGAREMDQRKRQKDFTHTTIHDKNS
What is the function of this protein?
Probable thioesterase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461).  The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable).  The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable).  The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable).  Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable).  On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable).  Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable).  The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable).  The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable).  The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
What are the official names of this protein?
Probable thioesterase FGSG_00047, Gramillins biosynthesis cluster protein FGSG_00047.
What is the protein family that this protein belongs to?
Belongs to the AMT4 thioesterase family.
Protein: CYDD_HAEIN
Sequence: MNKLRQKYLQKWLRAQQEPIKKLMRANIVLATLSSFILVAQTYFLATLLDKLIMQNVPRDELIPYFLGLIIGFGMRAIILWAREKIGFQSGQLLRNHIRQKILDKIHLVGPATINQKPAGSWASIMLEQVENLHNFYARFLPQQSLSAIVPVVIFIAVFPLNWAAGLILMITAPLVPLFMIIVGIAAADNSQKNMDTLSRLSAQFLDRLRGLETLRLFNRTSEQTEHIENATEDFRETTMDVLKLAFLSSAVLEFFTSISIALMAVYFGFSYLGQIEFGTYNAPLTLFTGFFCLILAPEFYQPLRDLGTYYHDRAAGIGAADAIVDFLESDYLTVHQNEKTISLESAVEISAENLVVLSTQGSALTKPLNFQIPANHNVALVGQSGAGKTSLMNVILGFLPYEGSLKINGQELRESNLADWRKHIAWVGQNPLLLQGTIKENLLLGDVQANDEEINQALMRSQAKEFTDKLGLHHEIKDGGLGISVGQAQRLAIARALLRKGDLLLLDEPTASLDAQSENLVLQALNEASQHQTTLMITHRIEDLKQCDQIFVMQRGEIVQQGKFTELQHEGFFAELLAQRQQDIQ
What is the function of this protein?
Part of the ABC transporter complex CydDC that exports the reduced low-molecular-weight thiols cysteine and glutathione to the periplasm.  Export of these thiol-containing redox-active molecules may be crucial for redox homeostasis in the periplasm, permitting correct assembly of various respiratory complexes and formation of correct disulfide bonds in periplasmic and secreted proteins.  CydD contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Required for the assembly of functional cytochrome bd-type quinol oxidases and periplasmic c-type cytochromes.
What are the official names of this protein?
Glutathione/L-cysteine transport system ATP-binding/permease protein CydD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3.A.1.129.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: S35G4_HUMAN
Sequence: MAGSHPYFNLPDSTHPSPPSTPPSLHWHQRCQPSDATNGLLVALLGGGLPAGFVGPLSRMAYQASNLPSLELVICRCLFHLPIALLLKLRGDPLLGPPDIRGRTCFCALLNVLNIGCAYSAVQVVPTGNAATVRKHSSTVCSAILTLCLESQVLSGYDWCGLLGSILGLIIIVGPGLWTLQEGTTGVYTGLGYVQAFLGGLALSLGLLVYRSLHFPSCLPTVAFLSGLVGLLGSVPGLFVLQSPVLPSDLLSWSCVGAVGILTLVSFTCVGYAVTKAHPALVCAVLHSEVVMALILQYFMLHETVAPSDIMGAGVVLGSIAIITARNLICERTGKVEE
What are the official names of this protein?
Putative solute carrier family 35 member G4, Acyl-malonyl-condensing enzyme 1-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the SLC35G solute transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RR12_SORBI
Sequence: MPTVKQLIRNARQPIRNARKSAALKGCPQRRGTCARVYTINPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYRIIRGTLDAVAVKNRQQGRSKYGAKKPKK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LCF3_YEAST
Sequence: MSEQHSVAVGKAANEHETAPRRNVRVKKRPLIRPLNSSASTLYEFALECFNKGGKRDGMAWRDVIEIHETKKTIVRKVDGKDKSIEKTWLYYEMSPYKMMTYQELIWVMHDMGRGLAKIGIKPNGEHKFHIFASTSHKWMKIFLGCISQGIPVVTAYDTLGESGLIHSMVETESAAIFTDNQLLAKMIVPLQSAKDIKFLIHNEPIDPNDRRQNGKLYKAAKDAINKIREVRPDIKIYSFEEVVKIGKKSKDEVKLHPPEPKDLACIMYTSGSISAPKGVVLTHYNIVSGIAGVGHNVFGWIGSTDRVLSFLPLAHIFELVFEFEAFYWNGILGYGSVKTLTNTSTRNCKGDLVEFKPTIMIGVAAVWETVRKAILEKISDLTPVLQKIFWSAYSMKEKSVPCTGFLSRMVFKKVRQATGGHLKYIMNGGSAISIDAQKFFSIVLCPMIIGYGLTETVANACVLEPDHFEYGIVGDLVGSVTAKLVDVKDLGYYAKNNQGELLLKGAPVCSEYYKNPIETAVSFTYDGWFRTGDIVEWTPKGQLKIIDRRKNLVKTLNGEYIALEKLESVYRSNSYVKNICVYADESRVKPVGIVVPNPGPLSKFAVKLRIMKKGEDIENYIHDKALRNAVFKEMIATAKSQGLVGIELLCGIVFFDEEWTPENGFVTSAQKLKRREILAAVKSEVERVYKENS
What is the function of this protein?
Activates endogenous long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids (PubMed:8206942).  Acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10 (PubMed:8206942).
What are the official names of this protein?
Long-chain-fatty-acid--CoA ligase 3, Fatty acid activator 3, Long-chain acyl-CoA synthetase 3.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: YQGF_MYCBP
Sequence: MVPAQHRPPDRPGDPAHDPGRGRRLGIDVGAARIGVACSDPDAILATPVETVRRDRSGKHLRRLAALAAELEAVEVIVGLPRTLADRIGRSAQDAIELAEALARRVSPTPVRLADERLTTVSAQRSLRQAGVRASEQRAVIDQAAAVAILQSWLDERLAAMAGTQEGSDA
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSA_PSEPK
Sequence: MTDFTPDAILDATGLNCPEPVMMLHQHVRNLAAGGLLKVIATDPSTRRDIPKFCNFLGHELLQQQEDAGTFLYWIRKKAD
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KRT35_SHEEP
Sequence: MASKCLKASFSSGSLKVPGGAGGGSARVSTIFSSSSCKLSGLSRGPRSFSACSVGLGKSSCRAASCLPALCLPSGGFATSYGMAGGWFGEGILTGNEKETMQFLNDRLASYLEKVRQLERENAELESRIRDWCEQQVPYLCPDYQSYFQTIEELQKKILCTKSENARLVVQIDNAKLAADDFRTKYETEVTMRQLVESDMNGLRRILDDLTLCKADLEAQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRVLNEMRCQYETLVENNRREAEDWFNTQTEELNQQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHSMRDALESTLAETEARYSSQLAQMQGLIGNVESQLAEIRCDLERQNQEYQVLLDVRARLECEISTYRGLLDSEDCKLPCNPCAPDHSPSKSCLPCLPAASCGPGTAHTTCSPRPICVSCPGSRF
What are the official names of this protein?
Keratin, type I cuticular Ha5, Keratin-35, K35.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: IBPA_ECODH
Sequence: MRNFDLSPLYRSAIGFDRLFNHLENNQSQSNGGYPPYNVELVDENHYRIAIAVAGFAESELEITAQDNLLVVKGAHADEQKERTYLYQGIAERNFERKFQLAENIHVRGANLVNGLLYIDLERVIPEAKKPRRIEIN
What is the function of this protein?
Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpA, 16 kDa heat shock protein A.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADD_STRT2
Sequence: MTAIDFHKLAKIELHCHLDGSLSLSTIRHLAELAQIDLPEDDEELKQHVTAPVTCESLLEYLESFDYIRPLLQTNEALTIAAYDVAKQAALENVIYIEVRFAPELSMDKGLTVTETIDAVCQGLRQAQEEFGIIAKALVCGMRQSDQSLTARILDEANQVRDSDFVGFDFAGDELNYGPAAIKPLIEQVKSYNRPMTFHAGECGCPAFLAESIAMGIKRNGHATILAQEPELLDEFVKNGVTGELCLTSNLQTKAAVTVNDFPYLKMKAAGANITINTDNRTVSDTNLTKEYELYHKYFDSTVQDFYAHNKTAIEASFASDEEKEELLARLAKAYS
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: RBL_METAC
Sequence: MRRDYVDPGYSPKDTDLICEFHIEPAAGISFEEASTHMAGESSIDSWTEISTLSPELAARLKPHVFYLDADTQTVRVAYSEDLFELGSVPQVLSAVAGNIFSMKIVDNLRLQDITFPKSMLREFEGPNFGLPGVRDIVGVKDRPLVGTIVKPKVGLTSEMHAEVAYNAFAGGCDLVKDDENLTDQKFNGFEKRAELTLKIAEKAEAETGERKMYLCNITAPTCEEMIRRLHVLKDLGASYAMIDIVPTGWTALQTLREAAADEGLALHAHRCMHSAFTRNPRHGVSMLLVAKLCRLIGLDQLHIGTVVGKMHGDKDEVLSIRDECVLDTVPADPEQHVLAQDWGGLKPMFPVASGGLAPTMIPDLYSIFGKEVIMQFGGGIHAHPMGTAAGAAACRQALEASLEGISLQDYAKDHKELEAALGKWLEK
What is the function of this protein?
Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA).  Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
What are the official names of this protein?
Ribulose bisphosphate carboxylase, RuBisCO.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type III subfamily.
Protein: RIMM_XYLFM
Sequence: MKDNERRILLGRVVGGFGLRGEIKMESWTEPRDAIFRYQPWLLRSPTGTESMLNGARGYDTGKRLIATFPGINDRNAVEAICGTEIYVPRSALPPPHPDEYYWVDLEGLQVHTLEGVVLGSVSHLFSNGANDVVVIHGERERLIPFVQPDYVKSVDFEAERIVVDWDPEF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CATB_STAAU
Sequence: MSQQDKKLTGVFGHPVSDRENSMTAGPRGPLLMQDIYFLEQMSQFDREVIPERRMHAKGSGAFGTFTVTKDITKYTNAKIFSEIGKQTEMFARFSTVAGERGAADAESDIRGFALKFYTEEGNWDLVGNNTPVFFFRDPKLFVSLNRAVKRDPRTNMRDAQNNWDFWTGLPEALHQVTILMSDRGIPKDLRHMHGFGSHTYSMYNDSGERVWVKLHFRTQQGIENLTDEEAAEIIATGRDSSQRDLFEAIEKGDYPKWTMYIQVMTEEQAKNHKDNPFDLTKVWYHDEYPLIEVGEFELNRNPDNYFMDVEQVAFASTNIIPGLDFSPDKMLQGRLFSYGDAQRYRLGVNHWQIPVNQPKGVGIENICPFSRDGQMRVVDNNQGGGTHYYPNNHGKFDSQPEYKKPPFPTDGYGYEYNQRQDDDNYFEQPGKLFRLQSEGAKERILQIQQMQWKA
What is the function of this protein?
Catalytically inactive.
What are the official names of this protein?
Catalase-like protein.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
Protein: INT9_CHICK
Sequence: MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSKLPGLVLKDGSTFLDKELKECSGHVFVDSVPEFCLPETELLDLSTVDVILISNYHCMMALPYITEYTGFTGTVYATEPTVQIGRLLMEELVNSIERVPKAQSASTWKNKEVQRLLPAPLKDAVEVSMWRKCYTMPEVNAALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLILTGLTQIPTANPDGMVGEFCSNLAMTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSNVPFYFISPVANSSLEFSQIFAEWLCHNKQTKVYLPEPPFPHAELIQTNKLKHYPSIHGDFSNDFKQPCVIFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLDALAPYQPLAMKCVYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPSQSHRTDLMIDCQPPPMSYRRAEVLTLPYKRRYEKIEIMPELADSLVPLEIKPGISLATVSAMLHTKDNKHVLQLPPKPPQPPTSKKRKRVSDDVPECKPLKPLLSGSIPVDQFVQTLEKHGFSDVKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEPLRVKLRDLVLKFLQKF
What is the function of this protein?
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
What are the official names of this protein?
Integrator complex subunit 9, Int9.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: VAPD_DICNO
Sequence: MYAIAFDLEIAELKKHYGEPYNGAYLEIGKELKAIGFEWTQGSVYLSNDNNLATVYRAISTLSKIDWFKSSVRDIRAFKVEDWSDFTAIVKGA
What is the function of this protein?
Cleaves ssRNA, mostly between U:A.
What are the official names of this protein?
Endoribonuclease VapD, Virulence-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the VapD ribonuclease family.
Protein: AMIE_ALCBS
Sequence: MRHGDISSSNDTVGVAVVNYKMPRLHSKAEVLDNARNIAEMIKGMKKGLPGMDLVVFPEYSTMGIMYDPDEMMATAATIPGDETAIFSAACREANTWGVFSLTGEQHEEHPAKAPYNTLVLINNEGEIVQKYRKCIPWCPIEGWYPGDTTYVTEGPKGMKISLIICDDGNYPEIWRDCAMKGAELIVRCQGYMYPAKEQQVMMAKSMAWANNCYVAVANASGFDGVYSYFGHSALIGFDGRTLGECGEEDMGIQYAQLSVSQIRDARANDQSQNHLFKLLHRGYTGMHASGDGDKGIADCPFDFYRTWVMDAQKAQENVEAMTRSTIGVAECPVGELPVDGKERTAGE
What is the function of this protein?
Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.
What are the official names of this protein?
Aliphatic amidase, Acylamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: INHA_MYCTU
Sequence: MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
What is the function of this protein?
Is the primary target of the first-line antitubercular drug isoniazid (INH) and of the second-line drug ethionamide (ETH) (PubMed:8284673, PubMed:12406221, PubMed:16906155, PubMed:17227913).  Overexpressed inhA confers INH and ETH resistance to M. tuberculosis (PubMed:12406221).  The mechanism of isoniazid action against InhA is covalent attachment of the activated form of the drug to the nicotinamide ring of NAD and binding of the INH-NAD adduct to the active site of InhA (PubMed:9417034, PubMed:16906155).  Similarly, the ETH-NAD adduct binds InhA (PubMed:17227913).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR, Enoyl-ACP reductase, FAS-II enoyl-ACP reductase, NADH-dependent 2-trans-enoyl-ACP reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.
Protein: MGGB_PETMO
Sequence: MKRFLGILVFVVMVLSVFAGPNHLVIFHMNDTHGHVWGTEDGGGFARAATLINQAREEVAKEGGAVLFLHAGDVNTGIPESDQLDAVPDFLALHYMGLDAMSLGNHEFDKPFEVLEKQYEVAQFPFLGANFVNEKRGGPVFEPYIIKDYGDFSVGIIGLVTEQTKVLEPIYLGENTIVDAEETLNMYLPIVQEKADVVIVLAHLGYHADGGRPNLSVEFTTSDELAENVSGVDIIIDGHSHTLLETPVVINNVIVAQAGDNAENIGRIDLWIDDGRIVDWRGEVIPLTSDIPEDPFIKMFTDAFYQLGSEALNEVVGVTKVYLDGERAHVRSDETNLSNLIADGMIWKTGADVALMNGGGIRASIEAGEITYRDILTVLPFGNTLYVLELTGKDIMDVLNYAATIPDGQGAKLHVAGLTAEIKGGKATNVKINGKPIDLNKTYKVVTNNYVAAGGDGYTMLAGKPGYDTYFRDADSLREYIAHLGTIEDYTSQERLIELDQVK
What is the function of this protein?
Involved in the biosynthesis of the compatible solute mannosylglucosylglycerate through a phosphorylating pathway.  Catalyzes the dephosphorylation of mannosylglucosyl-3-phosphoglycerate (MGPG) to mannosylglucosylglycerate (MGG).  Can also dephosphorylate UDP-glucose, ADP-glucose, GDP-mannose, glucosyl-3-phosphoglycerate (GPG), mannosyl-3-phosphoglycerate (MPG), ADP, GDP and UDP.
What are the official names of this protein?
Mannosylglucosyl-3-phosphoglycerate phosphatase, MGPG phosphatase.
What is the protein family that this protein belongs to?
Belongs to the 5'-nucleotidase family.
Protein: HIS4_SHEFN
Sequence: MIIPAIDLIDGQVVRLYQGDYDKQTTFDLSPLAQLQSYQAQGAKLLHIVDLTGAKDPNKRQTKLIAELAAGLDVDIQVGGGIRSEDQVAELLAIGVKRVVIGSLAVKEPELVKSWFVKYGSDAICLALDVNINDNGDKIVAVSGWQSGGGKSLESLVAEFETVGLKHALVTDISRDGTLTGANTELYTELAATYPNILWQASGGIATLDNVAAVRDSKASGIIIGKALLINQFTVEEAIQCWPNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETFB_THETC
Sequence: MNILVLIKQVPDTNEVRIDPVTKTLIREGVPSIINPDDKNALEEAIRIREKVGGKVTVISMGPTQAEVALREALAMGADEAYLLTDRAFAGADTYATAKALSKAIEKFQYDIVFCGRQAIDGDTAQVGPQIAEQLDIPQVTYVRKVEIEGDKLIVERALEDGYEIIEVKTPVLLTAIKELNVPRYPSIKGIFNAYNKKEVKILTADDLEVDKNELGLKGSPTKVVATSTPNTERAGEIFTGNIKEAVQNLVERLNSRHVI
What is the function of this protein?
The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases.  It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
What are the official names of this protein?
Electron transfer flavoprotein subunit beta, Beta-ETF, Electron transfer flavoprotein small subunit, ETFSS.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: RK22_TRICV
Sequence: MSNTQTVKAVAKYIRMSPHKVRRVLNQIRGRSYQEALMILEFLPYDAGGPVWQVVHSAAANAKNNYGLDKKKLIIEEVFANEGPKLKRIRPRAQGRAYSILKPTCHITVIVKGTS
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KSTR2_RHOJR
Sequence: MTPPPADDTSGKSGRRTELLDIAATLFAERGLRATTVRDIADAAGILSGSLYHHFDSKESMVDEILRGFLDDLFGKYREIVASGLDSRATLEALVTTSYEAIDASHSAVAIYQDEVKHLVANERFTYLSELNTEFRELWMGVLEAGVKDGSFRSDIDVELAFRFLRDTAWVAVRWYRPGGSVTVDTVAKQYLSIVLDGLASPHN
What is the function of this protein?
Controls the expression of a small regulon that may play a role in the utilization of cholesterol.
What are the official names of this protein?
HTH-type transcriptional repressor KstR2.
Protein: Y873_SULIY
Sequence: MSYPEANVLVTTAETIPGYTIVEVLGIVVGITVRSRGLGGNLMAALRSLVGGEIKEFVEMAEQARMQALIRMIDRAKELGANAVVNIRFDSNELNQSMDEIIAYGTAVKVAKNS
What are the official names of this protein?
UPF0145 protein YG5714_0873.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: HEM3_YERPA
Sequence: MLDKIIRIATRQSPLALWQAHYVQHLLQANHPGLQIELVPMVTRGDIILDTPLAKVGGKGLFVKELELALLDGRADIAVHSMKDVPIAFPEGLGLVTICEREDPRDAFVSSHYAHLDDLPAGSVVGTSSLRRQCQLRERRPDLIIRDLRGNVGTRLAKLDNGDYQAIILAVAGLKRLGLENRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAMNIRLEGGCQVPIGSYAELEGDTLWLRALVGAPDGSQMIRGERRGPAAEAEQMGIELADELLSRGAREILAAVYLDNPAR
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: DPO4_SCHPO
Sequence: MKILASSTNYVLHNRLSNSQYEDARSKIVNFGGEFTNDAAKADYIFVNYSQINRVRRELRTIGTPLETCVSCKLIVKIDWLNEPKESLTPGNPYVIWHRKPEMKVGSPYTPSTRPASHTEAPNDFENHETPNTENNNEVKSIDNVDQEGSVYPTTKEYPYVLEIPRYACQRKTPLKCVNQAFVNALSVLKTCREVNGESVRTRAYGMAIATIKAFPLPIDSAEQLEKMPGCGPKIVHLWKEFASTGTLKEAEEFQKDPASKILLLFYNIFGVGASHAAEWYQKGWRTIEQVRKHKDSFTKQIKVGLEFYEDFCKTVTIEEATEIYETIVSRMPDGIKIQSCLVGGFRRGKPVGADVDMVLSPSHTHSTKHLVDVLLRILDEEFQFRLISVQEHSCGGKKGYVMLAVILSNSSKINRRVDIIVVPPAYIGSAVLGWSGGIFFLRDLKLYANSHLGLSYDSFEIINLKTGKDICPDEFNEWKDPVEAEKDIFRYFSLEYIEPKFRNTG
What is the function of this protein?
Repair polymerase.  Involved in gap-filling in DNA non-homologous end joining (NHEJ) required for double-strand break repair.  Can incorporate a ribonucleotide (rNTP) into a primer DNA.
What are the official names of this protein?
DNA polymerase type-X family protein pol4.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-X family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SRP14_ORYSJ
Sequence: MVVLQPDPFLSELTSMYERSTEKGSVWVTMKRSSMKCQARLKKMAAKGEAVEYRCLVRATDGKKNICTALSAKEYLKFQASYATVLKAHMHALKKRERKDKKKAAEVEKIPEKAPKKQKKAPSSKKSAGSKS
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity).  SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity).  The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).
What are the official names of this protein?
Signal recognition particle 14 kDa protein, SRP14.
What is the protein family that this protein belongs to?
Belongs to the SRP14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRMD8_MOUSE
Sequence: MEGAEGNAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLSSISAHELHRAVREVLQLPDVALEAFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTNASDDDVAMDEPSLQFRRNVFFPRRRELQIHDEEVLRLLYEEAKGNVLTARYPCDLEDCEVLGGLVCRVQLGPYQPGQPAACTLREKLDSFLPAHLCKRGHGLFAAFRGRGAKTGPGEQGLLNAYRQVKEVTGNNSEREATLGSHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPVTVAISLEGVHVIDNREKHVLLGLRFQELSWDHTSPEEEEPVLWLEFDGDSEGTPVNKLLRIYSKQAELMSGLIEYCIELSQAAEPTLSQESASGPHEAPSPSPPPTQRPKLRRQGSVVCSRIQHLSTIDYVEDGKGIKRVKPKRTTSFFSRQLSSSQGSYTVVQPTDDSLEQS
What is the function of this protein?
Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway (PubMed:29897333).  By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity).  Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity).
What are the official names of this protein?
FERM domain-containing protein 8, iRhom tail-associated protein, iTAP.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane.