PharMolix/UniProtQA huggingface dataset:
Protein: DNA2_HUMAN
Sequence: MEQLNELELLMEKSFWEEAELPAELFQKKVVASFPRTVLSTGMDNRYLVLAVNTVQNKEGNCEKRLVITASQSLENKELCILRNDWCSVPVEPGDIIHLEGDCTSDTWIIDKDFGYLILYPDMLISGTSIASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAINNSFAPEKLQELAFQTIQEIRHLKEMYRLNLSQDEIKQEVEDYLPSFCKWAGDFMHKNTSTDFPQMQLSLPSDNSKDNSTCNIEVVKPMDIEESIWSPRFGLKGKIDVTVGVKIHRGYKTKYKIMPLELKTGKESNSIEHRSQVVLYTLLSQERRADPEAGLLLYLKTGQMYPVPANHLDKRELLKLRNQMAFSLFHRISKSATRQKTQLASLPQIIEEEKTCKYCSQIGNCALYSRAVEQQMDCSSVPIVMLPKIEEETQHLKQTHLEYFSLWCLMLTLESQSKDNKKNHQNIWLMPASEMEKSGSCIGNLIRMEHVKIVCDGQYLHNFQCKHGAIPVTNLMAGDRVIVSGEERSLFALSRGYVKEINMTTVTCLLDRNLSVLPESTLFRLDQEEKNCDIDTPLGNLSKLMENTFVSKKLRDLIIDFREPQFISYLSSVLPHDAKDTVACILKGLNKPQRQAMKKVLLSKDYTLIVGMPGTGKTTTICTLVRILYACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQIQKVHPAIQQFTEQEICRSKSIKSLALLEELYNSQLIVATTCMGINHPIFSRKIFDFCIVDEASQISQPICLGPLFFSRRFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQNKSAVVQLTVQYRMNSKIMSLSNKLTYEGKLECGSDKVANAVINLRHFKDVKLELEFYADYSDNPWLMGVFEPNNPVCFLNTDKVPAPEQVEKGGVSNVTEAKLIVFLTSIFVKAGCSPSDIGIIAPYRQQLKIINDLLARSIGMVEVNTVDKYQGRDKSIVLVSFVRSNKDGTVGELLKDWRRLNVAITRAKHKLILLGCVPSLNCYPPLEKLLNHLNSEKLIIDLPSREHESLCHILGDFQRE
What is the function of this protein?
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion.  Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1.  Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA.  Also involved in DNA replication checkpoint independently of Okazaki fragments processing.  Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities.  While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate.  According to various reports, the helicase activity is weak and its function remains largely unclear.  Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.
What are the official names of this protein?
DNA replication ATP-dependent helicase/nuclease DNA2, hDNA2, DNA replication ATP-dependent helicase-like homolog.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465).
Protein: MEND_ECOSM
Sequence: MSVSAFNRRWAAVILEALTRQGVRHICIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPTHSISLPRPTQDIPARWLVSTIDHALGTLHAGGVHINCPFAEPLYGEMDDTGLSWQQRLGDWWQDDKPWLREAPRLESEKQRDWFFWRQKRGVVVAGRMSAEEGKKVALWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKATSELQQAQIVVQLGSSLTGKRLLQWQASCEPEEYWIVDDIEGRLDPAHHRGRRLIANIADWLEQHPAEKRQPWCVEIPRLAEQAMQAVIARRDAFGEAQLAHRISDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASGKPTLAIVGDLSALYDLNALALLRQVSAPLVLIVVNNNGGQIFSLLPTPKNERERFYLMPQNVHFEHAAAMFELKYHRPQNWQELETALVDAWRTPTTTVIEMVVNDTDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: RL18_HELPS
Sequence: MNAKALYKKKALRDRRKLRIKSKLAGDALRPRVSVFRSNRYFYAQAIDDVKQSTITHIDGRKMGFKNTQEDAKKLGTLFAEELKKAGIERAVYDRNGYLYHGVVAAFAESLRENGIAL
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RS4_SYNFM
Sequence: MARYTDSSCRICRRETMKLYLKGDRCYSDKCAVERRNYPPGQHGQGRGKFSDYGLQLREKQKIRRMYGLVEKQFKTYFKHADRQKGVTGTNFLTLLERRIDNTVYRLGFASSRAQARQLVRHSHFLVNGKKVNIPSFLLRPGDSVSVVEGSRQLQMINEAMEAMPRRGLPPWLELDKAKYEGVFKTLPTREEMNLPVQEQLVVEFYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: GPDA_BURM9
Sequence: MLSMKVAVLGAGAWGTALAAHLAVRHDTLLWARDAALVAELAARRENARYLGGVALPPGLRYEADLATALSHAQADDALCVIAAPVAGLRALCRAMRDARRVPAHFVWVCKGFEADTRRLPHQMVAEELPDHASYGVLSGPSFAREVAQGLPVALTVASASAACRERTLAAFHHGAMRIYTGDDVVGVEVGGAVKNVLAIATGIADGLGLGLNARAALVTRGLAEMSRLGVALGGRAETFTGLTGLGDLILTATGDLSRNRSVGLQLAAGRSLDDILAALGHVAEGVRCARAVLSIARERGVDMPITEAVCAVLFDGVAPRDAVSGLLRRDAKAE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGT_STAAB
Sequence: MKRSDRYSNSNEHFEHMKHEPHYNTYYQPVGKPPKKKKSKRILLKILLTILIIIALFIGIMYFLSTRDNVDELRKIENKSSFVSADNMPEYVKGAFISMEDERFYNHHGFDLKGTTRALFSTISDRDVQGGSTITQQVVKNYFYDNDRSFTRKVKELFVAHRVEKQYNKNEILSFYLNNIYFGDNQYTLEGAANHYFGTTVNKNSTTMSHITVLQSAILASKVNAPSVYNINNMSENFTQRVSTNLEKMKQQNYINETQYQQAMSQLNR
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation using lipid-linked disaccharide-pentapeptide as the substrate.
What are the official names of this protein?
Monofunctional glycosyltransferase, MGT, Peptidoglycan TGase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HBB_STEMC
Sequence: VHWSAEEKQLITGLWGKVNVADCGAEALARLLIVYPWTQRFFSSFGNLSSPTAIIGNPMVRAHGKKVLTSFGEAVKNLDNIKNTFAQLSELHCDKLHVDPENFRLLGDILIIVLAAHFAKEFTPDCQAAWQKLVRVVAHALARKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SYG_PYRAB
Sequence: MGERFDKYEYLQDLMRRRGFAWGSFEIYGGSRGFYDYGPLGATIKRKIEKKIREAFIREGFFEIETPDITPEQVFIASGHVEKFVDPIVECKKCGARFRADHLIEETLGIDVEGKSAEEMTKIIREHNIKCPECGGELGDVFYFNLMFETYIGPYKDKKAYLRPETAQGIFVNFKRLNAFARNKLPFGVFQIGKAYRNEISPRQGMIRLREFTQAEVEIFFNPNETEHPHFDEVKHEKLRLYPIENQLKDLGMIELTAEEAVKKGYLMNTFFAYYLVMIKKILLDIGIPEDKIRFRQQLPEERAHYSADTWDAEVYSERFGWVECVGLAYRTDYDLSRHMKMSGADLTVMIHYDKPKIVKRLKVSLNMKSVGPKLKKDAKRINEKIQAMSEEELRELVKKLNEEGKIVIDGYELSKDDFIIKEVEEKVTGEKIIPHVLEPSFGIDRPFYLLLENSLTIDEDGRIYLKIKKDMAPIEVAVLPLVAKEPLTKIAYDLFRKLQKEGFIVVYDEKDSIGKRYMRYDEIGTPYCVTIDNQTPIDGTVTIRDRDTREQIRVKLEDVPRKLKELIFGS
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1632_HAEIN
Sequence: MPYLSVAKFGGTSVANHDAMTACAKIVIADPNTRVVVLSASAGVTNLLVALANGVKATEREKLIGNDLHITSGVAKRIFDTVQSYNVRMISYGASTNNVCMLVQSEHSDEIVRSLHKSLFE
What are the official names of this protein?
Putative inactive aspartokinase 3 HI_1632.
What is the protein family that this protein belongs to?
Belongs to the aspartokinase family.
Protein: CAH13_HUMAN
Sequence: MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH
What is the function of this protein?
Reversible hydration of carbon dioxide.
What are the official names of this protein?
Carbonic anhydrase 13, Carbonate dehydratase XIII, Carbonic anhydrase XIII, CA-XIII.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
Protein: YIDC_STAAE
Sequence: MKKKALLPLFLGIMVFLAGCDYSKPEKRSGFFYNTFVDPMKNVLDWLGNNLLNDNYGLAIIILVLVIRIILLPFMLSNYKNSHMMRQKMKVAKPEVEKIQEKVKRARTQEEKMAANQELMQVYKKYDMNPIKSMLGCLPMLIQLPIIMGLYFVLKDQLVDGLFKYPHFLWFDLGRPDIWITIIAGVLYFIQAYVSSKTMPDEQRQMGYMMMVISPIMIIWISLSSASALGLYWSVSAAFLVVQTHFANIYYEKVAKKEVQPFIEAYEREHNGGSNKKGKNTQVVSKKKKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CYB_PLAGN
Sequence: MTNIRKTHPLVKIINNTFIDLPTPSNISSWWNFGSLLGLCLIMQILTGLFLAMHYTPDTTTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLYAHVGRALYYGSYTFQETWNIGILLLFTLMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGSTLVEWIWGGFSVDKATLTRFFAFHFILPFIILTLAIIHLLFLHETGSNNPTGIPSDTDKIPFHPYYTIKDTLGALILILTSLTLTLFTPDLLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILVLAFIPMLHTSKQRSMMFRPFSQLLFWMLVADFLTLTWIGGQPVEHPYMLLGQLASILYFLLILVLMPTASLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CRTB_CERS4
Sequence: MIASADLDACREMIRTGSYSFHAASRLLPERVRAPSLALYAFCRVADDAVDEAVNDGQREEDAEVKRRAVLSLRDRLDLVYGGRPRNAPADRAFAAVVEEFEMPRALPEALLEGLAWDAVGRSYDSFSGVLDYSARVAAAVGAMMCVLMRVRDPDVLARACDLGLAMQLTNIARDVGTDARSGRIYLPRDWMEEEGLPVEEFLARPVVDDRIRAVTHRLLRAADRLYLRSEAGVCGLPLACRPGIYAARHIYAGIGDEIARNGYDSVTRRAFTTRRQKLVWLGLSATRAALSPFGPGCATLHAAPEPEVAFLVNAAARARPQRGRSEALISVLAQLEAQDRQISRQRLGNRANPI
What is the function of this protein?
Involved in the biosynthesis of carotenoids.  Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity).
What are the official names of this protein?
Phytoene synthase, PSase.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family.
Protein: RAVA_YERPB
Sequence: MAQSSQLAERISRLSHALESGLYERQEAIRLCLLAALSGESVFLLGPPGIAKSLIARRLKFAFRHARAFEYLMTRFSTPEEVFGPLSIQALKEEGRYQRMTGGYLPEAEIVFLDEIWKAGPAILNTLLTAINERRFRNGDREDSIPMRLLVTASNELPDADSSLEALYDRMLIRLWLDRVQEKQNFRSLLISRQNENHNPVAENLSITDEEFHQWQPLIDKITLPDHCFELIFQLRQRLSALEHAPYVSDRRWKKALRLLQASAFFSGRDEITPIDLILLKDCLWHDLNSFKLLQQQLEQLLTEQGYQQQSLLMKLQDINSKWLQHQQQQSDHQALTVVKQSGMFSRKAQYALPDNLTDSTLTLLLQKPLNLHDIQVNHLQVDKEALAQWLNKGGALRAKLNGVGYAQSIDAEIDDQLHIIILDVSRQPSTLSLPGATTTSVPPELLLALTKLESTLAEQRRLFSQHQPCLFTPSSWLAKIEASLLQVVEQLQFQQIQFQQRKFQQQKHSGH
What is the function of this protein?
Functions as an ATPase.  May play a role in metal insertion (metal-chelatase) or as a chaperone.
What are the official names of this protein?
ATPase RavA, Regulatory ATPase variant A.
What is the protein family that this protein belongs to?
Belongs to the RavA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_BORBZ
Sequence: MSRKNKKIKKKVFVDTRYNSRIVAKFANRMMYDGKKSISESILYSSIDLLADKLEESDKMAVFYKALDNIKPLVEVRSRRVGGATYQVPVEVREERREALAMKWIIFAARKSSGRSMKEKLSNELLNAYNSTGAAFKKKEDTHRMAEANKAFTHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: LACC1_MOUSE
Sequence: MAEAVLIDLSGLQLNAQKNCHETLLETLDGIHYHHAPKAKFLCIICCRNASKEKDGEYGLCELEAGNGFSRLAGKFETVSHPCLAASLYTIKQKIDEENLSCIKVIVPEHRKLLMKAYVGQLFTEVYEFEFEDLQGAWRDSLLKPSTGINVTTTQELEDIQHEIETYLRSLPALKGDLTIVTSPLIPDNFLHGFTTRTGGISSVPTLSSLNLFSSSKRRDPKVVVQENVRRLANAAGFNAEKFYRIKTDHASEVWVMGKKEPESYDGIVTNQRGVTITALGADCIPIVFADPVKKACGVAHSGWKGTLLGVAMATVNAMIAEYGCDVEDIIVVLGPSVGSCCFTLPKESAVSFHSLHPSCVRHFDSPRPYVDIRKATRILLERGGILPQNIQDQKEDLDLCTSCHPEKFFSHVRDGLNFGTQIGFISLRE
What is the function of this protein?
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (By similarity).  Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (By similarity).  Also has adenosine deaminase activity (By similarity).  Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:27478939, PubMed:31978345).  Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed:31978345).  The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345).  Participates in pattern recognition receptor-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (By similarity).  Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (By similarity).  Does not show laccase activity (By similarity).
What are the official names of this protein?
Purine nucleoside phosphorylase LACC1, Adenosine deaminase LACC1, Fatty acid metabolism-immunity nexus, Guanosine phosphorylase LACC1, Laccase domain-containing protein 1, S-methyl-5'-thioadenosine phosphorylase LACC1.
What is the protein family that this protein belongs to?
Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endoplasmic reticulum. Peroxisome. Note=Upon stimulation of the pattern- recognition receptor (PRR) NOD2, localizes to the endoplasmic reticulum.
Protein: LOH1_ARATH
Sequence: MGLFESVKSIDWEQESFPTYQDLGFLPLFAVFFPTIRFLLDRFVFEKLASLVIYGRMSTNKSDNIKDRKKNSPKVRKFKESAWKCIYYLSAELLALSVTYNEPWFSNTLYFWIGPGDQIWPDQPMKMKLKFLYMFAAGFYTYSIFALVFWETRRSDFGVSMGHHITTLVLIVLSYICRLTRAGSVILALHDASDVFLEIGKMSKYCGAESLASISFVLFALSWVVLRLIYYPFWILWSTSYQIIMTVDKEKHPNGPILYYMFNTLLYFLLVLHIFWWVLIYRMLVKQVQDRGKLSEDVRSDSESDDEHED
What is the function of this protein?
Essential for plant growth, promotes cell division in root meristems (PubMed:21666002, PubMed:21883234, PubMed:26276842).  Catalyzes the biosynthesis of ceramide sphingolipids with C(16) to C(28) fatty acids, structural membrane lipids involved in membrane trafficking (e. g.  early endosomes) and cell polarity (e. g.  polar auxin transport related proteins); mostly active with t18:0 and saturated very long saturated fatty acids (C24:0 and C26:0), such as long-chain base (LCB) phytosphingosine (t18:0), lignoceroyl- and hexacosanoyl-CoAs (PubMed:21883234, PubMed:26635357, PubMed:21666002, PubMed:26276842).  Mediates resistance to sphinganine-analog mycotoxins (SAMs, e. g.  fumonisin B(1)) by restoring the sphingolipid biosynthesis (By similarity).  Could salvage the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in ceramides-depleted cells after SAM exposure (By similarity).  May prevent precocious cell death by delaying PR1 accumulation during aging (PubMed:21883234).  Contributes to hypoxic conditions tolerance (e. g.  submergences), especially in the dark, by promoting the formation of very-long-chain (VLC) ceramide species (22:1, 24:1 and 26:1) and of VLC unsaturated ceramides, which are modulating CTR1-mediated ethylene signaling leading to endoplasmic reticulum (ER)-to-nucleus translocation of EIN2 and EIN3 (PubMed:25822663).
What are the official names of this protein?
Ceramide synthase LOH1, CS1, CSII, Protein LONGEVITY ASSURANCE GENE ONE HOMOLOG 1, LAG One Homolog 1, LAG1 homolog 1, LAG1 longevity assurance homolog 1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DNAK_XANOR
Sequence: MGKIIGIDLGTTNSCVSIMDGGKARVIENSEGDRTTPSIVAYTKDGEVLVGASAKRQAVTNPKNTFYAVKRLIGRKFTDAEVQKDISHVPYGILAHDNGDAWVQTSDAKRMAPQEISARVLEKMKKTAEDYLGEKVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKKGGDRKIAVYDLGGGTFDVSIIEIAEVDGEKQFEVLATNGDTFLGGEDFDNRVIEYLVDEFNKDQGIDLRKDPLALQRLKDAAERAKIELSSSQQTEVNLPYVTADASGPKHLNIKLTRAKLEALVEDLVKKSIEPCRTALNDAGLRASDINEVILVGGQTRMPKVQQAVADFFGKEPRKDVNPDEAVAVGAAIQGGVLAGDVKDVLLLDVTPLSLGIETMGGVFTKIIEKNTTIPTKASQTFSTAEDNQSAVTVHVLQGEREQARFNKSLAKFDLSGIEPAPRGMPQVEVSFDIDANGILHVSAKDKKTNKEQKVEIKAGSGLSDEEIQRMVADAEANREEDKKFHELVQARNQADGLIHATRTAITEHGSKVGGDVIGKVEAALSDLETAVKGDDKAQIEARTKTLEEAGQSLYAAAAAAEQGGSADAASGNAQASKAADDVVDAEFTEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ACCA_SALCH
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQVAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLEGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMEMAERFNMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLNVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLEDLADLDVLSTDDLKNRRYQRLMSYGYA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADD_DESPS
Sequence: MKKIGLFGGTFNPLHNGHLQLAEFAAAQCQLDQVVFLPAASPPHKKGDEIVPFSHRAEMIRLACSRNKRFSCNTIEQDLARPSYTVDTLQALKTSPLYKSEAQFFFLIGVDAFIELKTWKAYRDLLSEINFILCPRKLFSRTQTVLFLTELGFVQTPLGWEHSSYLTLYELEGAPDQVSSTEVRRTFEKSGDLYQKLPPTVADYIMKHGLY
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: QUEA_SYNY3
Sequence: MDQDKYLSSYDYHLPADCIAQTPAVPRDHSRLLVVKDPFTVDHQHFYDLGNYLKPGDLLVLNDTKVMPARLHGQKENGVAVEILLLTECTENQWIALVKPGKRLKLGAKVKFPARDGEKPDLWATILQRDDATGGRLLEFVLEPGQRLWDVLPDYGEIPFPPYIGDRQATNDQYQTIYAEKLGAVAAPTAGLHFTEELFTKLAQQGVQTAKVTLHVGIGTFRPVEAENILDHVMHQEWIDVPPTTVEVIEKTRASGGRIFAVGTTVVRCLEGMAQESDFPRQPLQPFRGQTDLFIYPGYQWRLVDGLITNFHLPKSSLLMLVSALISRPRLMAIYETAIAKGYRFYSFGDAMVILPEACRGQEKIR
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFCS_STAMF
Sequence: MSSSREVIAELLWAEKYRPKTLDEIVDQEEIVSRLKQFVKERNMPHLLFAGPPGTGKTTAAHCLAHDLFGENYRQYMLELNASDERGIDVIRSKVKEFARTRVAANIPFKIVLLDEADNMTADAQQALRRLMEMYTATTRFILIANYPSKIIEPIQSRCAVFRFAPLKKEDVISRLKWIAEQEKVEIDEEALEAIHDLSEGDMRRAINILQAAAALGKVTVDSVYKVVGLAHPREIRQMIQLALAGNFNDAREKLRELMINYGLSGVDVIKQVHREIFSTDIKIPDEFKIIIADLAGEIQFRLVEGADDEIQLNAFLARLAFLGKKLKP
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C small subunit, RFC small subunit, Clamp loader small subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcS subfamily.
Protein: C1GLT_BOVIN
Sequence: MASKSWLNILTFLCGSAVGFVLCSQLLSILFEEQKDIQPSILHNDPHARHSDDNEQNHLEGQMNFDADASQHKDENTDIADKLYQKVKILCWVMTGPQNLEKKAKHVKATWAQRCNKVLFMSSEENKDFPAVGLKTREGRDQLYWKTIKAFQYVHDHYLEDADWFMKADDDTYVILDNLRWLLSKYNPEEPIYFGRRFKPYVKQGYMSGGAGYVLSKEALKRFVEAFKTDKCTHSSSIEDLALGRCMEIINVEAGDSRDTTGKETFHPFVPEHHLIKGYLPRTFWYWNYNYYPPVEGPGCCSDLAVSFHYVDPTTMYELEYLVYHLRPYGYLYRYQPALPEKMLKEVSQIYKNEDTNVNQEPLKEKHK
What is the function of this protein?
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.  Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity).
What are the official names of this protein?
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, Core 1 O-glycan T-synthase, Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1, Core 1 beta1,3-galactosyltransferase 1, C1GalT1, Core 1 beta3-Gal-T1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.