PharMolix/UniProtQA huggingface dataset:
Protein: FZD4_MOUSE
Sequence: MAWPGTGPSSRGAPGGVGLRLGLLLQFLLLLRPTLGFGDEEERRCDPIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLREFGFAWPDTLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGSNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGNETVV
What is the function of this protein?
Receptor for Wnt proteins (PubMed:10097073).  Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:19837033).  Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (PubMed:19837033).  In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (PubMed:19837033).  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism.
What are the official names of this protein?
Frizzled-4, Fz-4, mFz4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TMP_BPDP1
Sequence: MDFGSIAAKMTLDISNFTSQLNLAQSQAQRLALESSKSFQIGSALTGLGKGLTTAVTLPLMGFAAASIKVGNEFQAQMSRVQAIAGATAEELGRMKTQAIDLGAKTAFSAKEAAQGMENLASAGFQVNEIMDAMPGVLDLAAVSGGDVAASSEAMASSLRAFGLEANQAGHVADVFARAAADTNAETSDMAEAMKYVAPVAHSMGLSLEETAASIGIMADAGIKGSQAGTTLRGALSRIAKPTKAMVKSMQELGVSFYDANGNMIPLREQIAQLKTATAGLTQEERNRHLVTLYGQNSLSGMLALLDAGPEKLDKMTNALVNSDGAAKEMAETMQDNLASKIEQMGGAFESVAIIVQQILEPALAKIVGAITKVLEAFVNMSPIGQKMVVIFAGMVAALGPLLLIAGMVMTTIVKLRIAIQFLGPAFMGTMGTIAGVIAIFYALVAVFMIAYTKSERFRNFINSLAPAIKAGFGGALEWLLPRLKELGEWLQKAGEKAKEFGQSVGSKVSKLLEQFGISIGQAGGSIGQFIGNVLERLGGAFGKVGGVISIAVSLVTKFGLAFLGITGPLGIAISLLVSFLTAWARTGEFNADGITQVFENLTNTIQSTADFISQYLPVFVEKGTQILVKIIEGIASAVPQVVEVISQVIENIVMTISTVMPQLVEAGIKILEALINGLVQSLPTIIQAAVQIITALFNGLVQALPTLIQAGLQILSALINGLVQALPAIIQAAVQIIMSLVQALIENLPMIIEAAMQIIMGLVNALIENIGPILEAGIQILMALIEGLIQVLPELITAAIQIITSLLEAILSNLPQLLEAGVKLLLSLLQGLLNMLPQLIAGALQIMMALLKAVIDFVPKLLQAGVQLLKALIQGIASLLGSLLSTAGNMLSSLVSKIASFVGQMVSGGANLIRNFISGIGSMIGSAVSKIGSMGTSIVSKVTGFAGQMVSAGVNLVRGFINGISSMVSSAVSAAANMASSALNAVKGFLGIHSPSRVMEQMGIYTGQGFVNGIGNMIRTTRDKAKEMAETVTEALSDVKMDIQENGVIEKVKSVYEKMADQLPETLPAPDFEDVRKAAGSPRVDLFNTGSDNPNQPQSQSKNNQGEQTVVNIGTIVVRNNDDVDKLSRGLYNRSKETLSGFGNIVTP
What is the function of this protein?
Plays a role in virion tail formation.  The length of the tape measure protein is proportional to the length of the phage's tail.
What are the official names of this protein?
Tape measure protein, TMP.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein. Virion.
Protein: TRUB_THIDA
Sequence: MKPARQAVDGVLLLNKPVGITSNAALQKAKWLLNAKKAGHTGTLDPFADGLLPLCFGEATKFSAYLLDADKRYRAILQLGVTTRTGDPEGEVLATREVRATCADIRAALPAFVGEIEQIPPMHSALKHQGRPLYEYARAGVEIARAPRRVHIRALDLFKCAPPRAVVDVQCSAGTYVRTLAEDLGNALGCGAHLTALTRTASGGFLLEQAHTLAELEATNAGARQALLLPADCLVAHLPSVHLGETAAASLRQGRSVPDAADRRGLVRVYDGHGVFVGLAEAEAGKLVPRRLIATVQA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RLMN_CAMC5
Sequence: MKNLLDYTLSELEAILSPKFRAKQIYEWIYKKNAENFDEMLNLPKDMRTNLAQEFYFDPLYCVKFEESSDGSIKYLFALKDGNTIESVLLPMKEVEVDEGGNISRHARYTICVSSQVGCKMGCLFCLTAKGGLKRNLSPGEIVGQILWIKKTNHIPYERRVNVVYMGMGEPLDNLANVAKAIQILKEPDGLAISPRRQTVSTSGLGAQIKKLGEMDLGVLLAISLHAVTNELRSKLMPVNKAYNIEAVMDAVRGFPIDMRKRVMFEYLVIRGMNDSVKDAKTLVKLLHGIKAKVNLIYFNPHEGSEYGRPELADMLEFQEYLRAHGVTCTIRQSKGLDISAACGQLKQRSQNLSPSNNNTSKPSDIKKSES
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_BRUA4
Sequence: MARVKRGVTAHAKHKKVLDQAAGFRGRRKNTIRTAKAAVDRSKQYAYRDRKNRKRSFRALWIQRINAAVREQGLTYGRFIDGLAKAGIEIDRKVLSDIAIHEPDAFGALVASAKKALEYLKNTETPNAFEGAVR
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RUVB_BACC1
Sequence: MDERLLSGESAYEDADLEYSLRPQTLRQYIGQDKAKHNLEVFIEAAKMREETLDHVLLYGPPGLGKTTLANIIANEMGVNVRTTSGPAIERPGDLAAVLTSLQPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATTRAGALSAPLRDRFGVLSRLEYYTVDQLSEIVERTAEVFEVEIDSLAALEIARRARGTPRIANRLLRRVRDFAQVRGNGTVTMEITQMALELLQVDKLGLDHIDHKLLLGIIEKFRGGPVGLETVSATIGEESHTIEDVYEPYLLQIGFLQRTPRGRIVTPLAYEHFGMEMPKV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: LPW_AZOBR
Sequence: MIFVATSLSCRWWWPVM
What is the function of this protein?
This protein is involved in control of the biosynthesis of tryptophan.
What are the official names of this protein?
trp operon leader peptide.
Protein: DOPP1_PLEMO
Sequence: MAADGQCSLPASWRPVTLTHVEYPAGDLSGHLLAYLSLGPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKNVIQEPRPCGGPHTAVGTKYGMPSSHSQFMWFFSVYSFLFLYLRMHQTNNARFLDLLWRHVLSLGLLAAAFLVSYSRVYLLYHTWSQVLYGGIAGGLMAVAWFIFTQEVLTPLFPRIAAWPISEFFLIRDTSLIPNVLWFEYTVTRAEARNRQRKLGTKLQ
What is the function of this protein?
Required for efficient N-glycosylation.  Necessary for maintaining optimal levels of dolichol-linked oligosaccharides.  Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate.  Does not act on phosphatidate (By similarity).
What are the official names of this protein?
Dolichyldiphosphatase 1, Dolichyl pyrophosphate phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the dolichyldiphosphatase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HEM1_IGNH4
Sequence: MPAAARVPLFVDDLVMVGVNYKTSGKELVEKAQFPDPLAAYSAISRIPAVREVVLLQTCNRVEVYAITTNKKATVESIKSLLEARAGEPIPEEKFVIYYGTDAVRHLFRVAAGLESMVLGEPDILRQVREAAEFAAKEGYIGKALKLTFENAVRVGKRVRTETALGKGSIGIPSASVKLLEELIGLEGKKLLVVGAGMAGRVVAVNAAKRGAKVIIVNRTLSKAKELAEEVGGEAYPLEELPRLLREADAVVVAVGGGSKVITRDAVAEVNKKLVIVDISEPPAVDPGVSLNPYVIYKDMLAVAEVANRGLEKRKSEIKRAEDIIEAELNKFVNFAQRVLADKILRELMEKVEQIRINELSKAMAKVPQEYAEVLDKMTSSLVKKVLKDVILKVREAAGKGDLTTLRIVAEVFDLKESLNNIEIIYDYNGVEQELKRKLEL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: TLR11_MOUSE
Sequence: MPRMERHQFCSVLLILILLTLVSLTLTGWAWTIPDCIIADSLLFPNLSYYIPFCTSAPGLHLLASCSNVKNLNQTLKRVPRNTEVLCLQGMVPTLPAKAFIRFHSLQLLRLQLRTTSVTSRTFQGLDQLQYLFFDHHAPCCLSLFLSPNCFESLRSLSSLSFQGYCLTYSQSIYLPTSLRHLTLRNSCLTKFQDLQRLFPDLLLSTSSTPNIKPGAPFLETLDLSYNLQLKQAGVRDLYGLTLHSLILDGTPLKALDLTDSGLLHLHFLSLVGTGIEKVPASLTGYSELRALDLGKNQIQNILENGEIPGYKALEFLSLHDNHLQTLPTRFLHTLPQLQKLNLSMNKLGPILELPEGLFSTNLKVLDLSYNQLCDVPHGALSLLSQLQELWLSGNNISSLSNESLQGLRQLRTLDLSWNQIKVLKPGWLSHLPALTTLNLLGTYLEYILGIQLQGPKMLRHLQLGSYPILDIYPPWPPTLLSLEIQAESCIQFMIHSGQPFLFLENLTLETSILLLKPDNITIHFPSLRRLTLRGYSFIFSTSQLQRFFPQQLPLLEHFFIWCENSYAVDLYLFGMPRLRVLELGYLNFFYESSTMKLEMLLKEVPQLQVLALSHLNLRNLSVSSFKSLQDLKLLLFNSERALEMNSNLQEFIPQMPQYVYFSDVTFTCQCEASWLESWATRAPNTFVYGLEKSICIANASDYSKTLLFSFLATNCPHGTEFWGFLTSFILLLLLIILPLISCPKWSWLHHLWTLFHTCWWKLCGHRLRGQFNYDVFISYCEEDQAWVLEELVPVLEKAPPEGEGLRLCLPARDFGIGNDRMESMIASMGKSRATLCVLTGQALASPWCNLELRLATYHLVARPGTTHLLLLFLEPLDRQRLHSYHRLSRWLQKEDYFDLSQGKVEWNSFCEQLKRRLSKAGQERD
What is the function of this protein?
Participates in the innate immune response to microbial agents.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
What are the official names of this protein?
Toll-like receptor 11, Toll-like receptor 12.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ZIPA_PSEP1
Sequence: MEIGLREWLILIGIIVIAGILFDGWRRMRGGKGKLKFRLDRSYSNLPDEEGGSAEVLGPSRVLDTHKEPELDESDLPSLSASARDREREPKPVKASKRGKRVSAAADVQQGDLNLSAEQREPDLFADSDDDFAADNNRSSGAAPASSSVKELPPAEEVLVISVISRDEGGFKGPALLQNILESGLRFGEMDIFHRHESMAGHGEVLFSMANAVKPGVFDLDDIDHFSTRAVSFFLGLPGPRHPKQAFDVMVAAARKLAHELNGELKDDQRSVLTAQTIEHYRQRIVEFERRALTQKR
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: 3MGH_MYCLB
Sequence: MRSPRRCKICAVSADQLVVDPVVAAHRLLGATITGRGVCAIVVEVEAYGGVPDGPWPDAAAHSYHGRNDRNAVMFGPPGRLYTYCSHGIHVCANVSCGPDGTAAAVLIRAGALENGADVARSRRGASVRTVALARGPGNLCSALGITMDDNGIDVFAADSPVTLVLNEAQEAMSGPRVGISHAADRPWRLWLPGRPEVSTYRRSPRAPAPGASD
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: GLND_ZYMMO
Sequence: MPVSFLSLASQPQIIDYPAIKEEIDSIKKVAAGDPVSEYRAVSLVLKQTVLKGREVIAEALTRRPHQGRIAALSYAYLTDQIIQLALYAMVGDDEKATDNLVILAVGGYGRGEMALHSDVDIAFLSRRSPRKAQKKLIESLISLLWDVGLRVSQSHRSLSDMVKMAKKDITIRTALLESRYLVGDKALFEEASTRFIQKVVAGSGRDFVAAKLLEWDERHLARGDSRYLVEPHLKEGKGGLRDLQSLFWIAKYLYLEKEARHTVLTSPILTDYALVKADLIAGHEAKRFRRCENFLWAVRCHLHILVKRPEERLNFDVQRSLAEKMGYRSKSGKSAVERFMHHYFLVTKMVGNLAALFIDALKVNHYLKPKSRRSGASKQIDGFPVIQGEIVLDDDFFFRHNPAALITLFAVAYRHRLDIHPLTLRQAGRDARLIDEALQNNPVCNAAFLTLFTLPYNPAPILKIMNNTGVLGRFIPDFGRIVAQMQFDMYHHYTVDEHAIRALDILWQIENNKLEDLYPLGSRLFKQLNARLVLYMALFLHDIAKGREGSHSALGAEIALRLCPRFGLTAAETKLVAWLVKNHLLMSHTAFQRDLADAKTITDFANAVKSPERLRLLYLLTVADISAVGPHIWNSWKNQLLTSLYEACSQCLLEGPTGHGAGRQQRIENRQNDVSEKLDWDNDLFHALVKRLPDDYWFSERTDVIAANMQQIIDTDSKGQSISVRGHEMPAYDATMISLYAIDHPGFFYRISGAIHATGGNILDARIHTTRDGMAMDNLLVQNSQGGMIKSGEHLNRMMQAIEDAATSHIRSSNKLAALRPPLFWRGKAFHVEPLVFIDNQASDRFTVIEVNAQDRPALLHDLGCALFNARLTISSAHIATYGERAVDVFYVSDLFSHKITNQNRLKAIEKRLLAAADAARISEK
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: SCP_EHV1V
Sequence: MAADKQQQQAPVAFNPADPPNIKAANFKDMLPVDVITILNQNIDELDYTKYTEDEISEGLKQLFMGTARTMVSLRQRHLKSLVRRSDMFAQNDASTWARPNIGLKRTFPPRFMQPISED
What is the function of this protein?
Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument.  Complexes composed of the major capsid protein and small capsomere-interacting protein/SCP assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly.
What are the official names of this protein?
Small capsomere-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae small capsomere-interacting protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: KDPA_BACCR
Sequence: MIWVAVIITMLLFILVAKPTGIYLEKAFQGSKTLDKVFGPFEKLIFKITGVKAYNQTWKQYALSLVLLNGFMIVVVYFIFRLQGVLPLNPAHIEGMEPTLAFNTAISFMADTNLQHYSGENGLSYLSQLIGITFLMFAAPATTLALVMAFIRGLAGKELGNFFVDFTRALTRVFLPIAFIAALVFVALGVPQTLDGAVTAQTIEGAKQSILRGPVASFVSIKELGNNGGGFFGANSTHPFENPGQMSNILQMMLMMLLPTALPFTYGRMVGNKKQGRILFVSLFMVFLLGFITITTSELNGNPALNGMGIEHVQGSTEGKEVRFGTVFSSLYATVTTAAETGAVNTMHDTLTPIGGLVPLVNMMLNTVYGGVGAGFVNIIMYAIIAVFISGLMVGRTPEFLGKKIEGKEMKLIAVTILFHPLLILGFSALALSTNLGTDAISHSGFHGLTQVVYEYTSSAANNGSGFEGLGDNTPFWNITTGLVMFLGRYFSLITMLAVAASLKEKTVVPETVGTFRTDNSLFGGIFIGTIVIVGALTFFPMLVLGPIAEFLTLK
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YPEA_SHIDS
Sequence: MEIRVFRQEDFEEVITLWERCDLLRPWNDPEMDIERKMNHDVSLFLVAEVNGEVVGTVMGGYDGHRGSAYYLGVHPEFRGRGIANALLNRLEKKLIARGCPKIQINVPEDNDMVLGMYERLGYEHADVLSLGKRLIEDEEY
What are the official names of this protein?
Acetyltransferase YpeA.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. YpeA subfamily.
Protein: DJC18_HUMAN
Sequence: MAATLGSGERWTEAYIDAVRRNKYPEDTPPESHDPCGCCNCMKAQKEKKSENEWTQTRQGEGNSTYSEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRARPYNYYRDFEADITPEELFNVFFGGHFPTGNIHMFSNVTDDTYYYRRRHRHERTQTQKEEEEEKPQTTYSAFIQLLPVLVIVIISVITQLLATNPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLHDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLKQKAESLKLENCEKLSKLIGLRRGG
What is the function of this protein?
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:25631089).  Regulates the recruitment of DNAJB12:DNAJB14 into SV40-induced foci and all cooperate to guide SV40 across the endoplasmic reticulum membrane.  The foci represent the site from which SV40 penetrates into the cytosol (PubMed:25631089).
What are the official names of this protein?
DnaJ homolog subfamily C member 18.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MINC_DICTD
Sequence: MSKISFKGDLKEGIKIIIDPNLNWDEIRNLIVDEIKSKEGFLKGSSIYVDFQGKDIKDEDWQEFRKEIYEKYGIMLSKELYRLRISNSNNAKIVLGPIRSGKSLNVKDNLLVIGDVNSGSEIICNKNVFVLGKVRGSIWAGYENNDKATIFALELEPEKIQIARYILDLSKIKKEKTGVGYWVYVENGEVKLNRYSGGKKNG
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: UP14_PSEMZ
Sequence: RIISSVAVAVAGTA
What are the official names of this protein?
Unknown protein 14.
Protein: ENY2_DROME
Sequence: MSTSGAVDQYTVLTGDRSKIKDLLCSRLTECGWRDEVRLMCRNILMEKGTNNSFTVEQLIAEVTPKARTLVPDAVKKELLMKIRTILTEIEEEPDEPEDES
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the TREX-2/AMEX and the SAGA complexes (PubMed:18034162, PubMed:19947544, PubMed:27016737).  The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination (PubMed:11438676, PubMed:18206972).  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B (PubMed:18206972).  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription (PubMed:18034162, PubMed:19947544).  Required for nuclear receptor-mediated transactivation (PubMed:20714859, PubMed:20048002).  Involved in transcription elongation by recruiting the THO complex onto nascent mRNA (PubMed:20048002).  The TREX-2/AMEX complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket) (PubMed:27016737).  TREX-2/AMEX participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:17643381, PubMed:27016737).  Recruited to the su(Hw) insulators via its interaction with su(Hw) and participates in the barrier activity of such insulators (PubMed:17643381).  In contrast, it does not participate in the enhancer-blocking activity of the su(Hw) insulators (PubMed:17643381).
What are the official names of this protein?
Enhancer of yellow 2 transcription factor.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Nucleus membrane; Peripheral membrane protein. Nucleus. Note=Localizes to nuclear periphery, in contact with the nuclear pore complex (NPC).
Protein: RL7_NEIMF
Sequence: MAITKEDILEAVGSLTVMELNDLVKAFEEKFGVSAAAVAVAGPAGAGAADAEEKTEFDVVLASAGDQKVGVIKVVRAITGLGLKEAKDIVDGAPKTIKEGVSKAEAEDIQKQLEEAGAKVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RL22_MYCMM
Sequence: MTTTTEFPSATAKARFVRVSPRKARRVIDLVRGRSVSDALDILRWAPQAASEPVAKVIASAAANAQNNNGLDPATLIVATVYADEGPTAKRIRPRAQGRAFRIRKRTSHITVVVESRPSKDQRSSKSSRARRAEGSKAAATAPAKKSSASKAPAKKAATKAESKTSETSEAKGGSD
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL29_YERPA
Sequence: MKAQELREKSVEELNTELLNLLREQFNLRMQAASGQLQQTHLLKQVRRNVARVKTLLTEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: VFD38_ASFP4
Sequence: MAHGRNIRKRTFSDMDTLSDKNIGIHTNSLPKNLLCRRILFKGKISKYSIFNDSLAKDHSSNRSMSIDGLIGKKRPHDISFQNMNSSMPSSTQKKTRILDEEIKDQSSSNENDRDSPVIVTLKPSYMPKTSRITEIIHKMKELNMNRIEDGLSFNKKRSEHDAKNVLLHTMEMEEDCEIEEDIAIDSPYLNTSLSEDDTESIVETDYSEEEKESISETESSSDDESYSLYDSF
What are the official names of this protein?
Uncharacterized protein DP238L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus DP238L family.
Protein: STX16_HUMAN
Sequence: MATRRLTDAFLLLRNNSIQNRQLLAEQVSSHITSSPLHSRSIAAELDELADDRMALVSGISLDPEAAIGVTKRPPPKWVDGVDEIQYDVGRIKQKMKELASLHDKHLNRPTLDDSSEEEHAIEITTQEITQLFHRCQRAVQALPSRARACSEQEGRLLGNVVASLAQALQELSTSFRHAQSGYLKRMKNREERSQHFFDTSVPLMDDGDDNTLYHRGFTEDQLVLVEQNTLMVEEREREIRQIVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNVEQSCIKTEDGLKQLHKAEQYQKKNRKMLVILILFVIIIVLIVVLVGVKSR
What is the function of this protein?
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
What are the official names of this protein?
Syntaxin-16, Syn16.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type IV membrane protein. SUBCELLULAR LOCATION: [Isoform C]: Cytoplasm.