PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_CAMJR
Sequence: MDRIVEIEKYSFDETYETSLRPSNFDGYIGQESIKKNLNIFIAAAKKRNECLDHILFSGPAGLGKTTLANIISYEMGANIKTTAAPMIEKSGDLAAILTNLSEGDILFIDEIHRLSPAIEEVLYPAMEDYRLDIIIGSGPAAQTIKIDLPKFTLIGATTRAGMLSNPLRDRFGMQFRLEFYKDSELALILQKAALKLNKTCEEKAALEIAKRSRSTPRIALRLLKRVRDFADVNDEEIITEKRANEALNSLGVNELGFDAMDLRYLELLTAAKQKPIGLASIAAALSEDENTIEDVIEPYLLANGYIERTAKGRIASAKSYSALKLNYEKTLFEE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: YP114_YEAST
Sequence: MDVLLSLPQPELFKTTVIPFLANRNIIKSEAILSNLHSIFYVAIFYHIWFLFGKWILFPHLVKWKLDYDQKHNVKKDEKTTSERQAQHYKKKYTSLINQSSVHLISLLQSIVVLYYSLKFLLDPKASAEPYQTSHSRVFTENRDTQVICIFAIGYFVWDIYISTMYSTFPFVVHGIISTVVFCIGLKPYIQYYAPVFLMFELSNPSLNFRWFGIKFLPQKSKFCSLLLLLNNLTLMVVFFAARIAWGWFQIGKLCYDFYQVRNEPGFLVFDTIVILAGNFVLDILNVIWFSTMVSVAAKVLKKGESVDKVTKNEQ
What are the official names of this protein?
Uncharacterized TLC domain-containing protein YPR114W.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PSBE_TRIEI
Sequence: MAGGSTGERPFGDIITSIRYWVIHSITIPALFIAGWLFVSTGLAYDVFGTPRPNEYYTEQRQELPILSDRFESKQQIDDFIK
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: STIP1_CAEEL
Sequence: MTDAAIAEKDLGNAAYKQKDFEKAHVHYDKAIELDPSNITFYNNKAAVYFEEKKFAECVQFCEKAVEVGRETRADYKLIAKAMSRAGNAFQKQNDLSLAVQWFHRSLSEFRDPELVKKVKELEKQLKAAERLAYINPELAQEEKNKGNEYFKKGDYPTAMRHYNEAVKRDPENAILYSNRAACLTKLMEFQRALDDCDTCIRLDSKFIKGYIRKAACLVAMREWSKAQRAYEDALQVDPSNEEAREGVRNCLRSNDEDPEKAKERSLADPEVQEILRDPGMRMILEQMSNDPGAVREHLKNPEIFQKLMKLRDAGVIQMR
What is the function of this protein?
Plays a role in gonad development.  Up-regulates longevity and thermotolerance.  Binds daf-21/hsp90 and inhibits its ATPase activity.
What are the official names of this protein?
Stress-induced-phosphoprotein 1, CeSTI1, STI1, Hsc70/Hsp90-organizing protein, CeHop, Hop.
Protein: NPAL2_HUMAN
Sequence: MAAVAPAGPGDSASAALDELSLNFTYGAPGAGNGSLSGDWYRRNQIHLFGVLLAILGNLVISISLNIQKYSHLQLAQQEHPRPYFKSVLWWGGVLLMAVGETGNFAAYGFAPITLIAPLGCVSVTGSAIISVTFLKDNLRASDLLGTTLAFAGTYLLVNFAPNITQAISARTVQYYLVGWQFLIYVILEILIFCILLYFYKRKGMKHMVILLTLVAILASLTVISVKAVSGMITFSVMDKMQLTYPIFYIMFIIMIASCVFQVKFLNQATKLYNTTTVVPVNHIFFTISAIIAGIIFYQEFLGAPFLTVFIYLFGCFLSFLGVFLVTRNREKEHLQQSYIDFGNIPGKQMLDKIQPDSHSLSYGTLPDGSDSTKSQSGEKKEV
What are the official names of this protein?
NIPA-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the NIPA family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CD123_YEAST
Sequence: MSSQEYTTFIDIPVTRAQVEHCSYSFWSSLYPKYVPKSIVLKSLPKKFIQYLEQDGIKLPQEENSRSVYTEEIIRNEDNDYSDWEDDEDTATEFVQEVEPLIDFPELHQKLKDALNELGAVAPKLNWSAPRDATWILPNNTMKCNEVNELYLLLNASNYIMHDLQRAFKGCVDGDDIKGLKFDLVLRQWCDMNPALEFRVFVKNAHIVGATQRDLNYYDYLDELSDTFKDLIDEIVHDVVLPKFPDKSFVLDVYIPRPFNKIFIVDINPFARKTDSLLFSWNEIAAIAPPKNDVEDYELRLVTRHNTGRFASKEHSENHVPQDLVEASLNPEAIRELTQKWKELLSQQAKEESSDSENET
What is the function of this protein?
Regulates the cell cycle in a nutrient dependent manner.  Accumulates in presence of nutrients and directs the destabilization of DMA1 and DMA2, whose accumulation results in a G1 block.  Regulates also the abundance of GCD11 an essential component of the translational initiation factor 2.
What are the official names of this protein?
Cell division cycle protein 123.
What is the protein family that this protein belongs to?
Belongs to the CDC123 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMNB2_HUMAN
Sequence: MSPPSPGRRREQRRPRAAATMATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM
What is the function of this protein?
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
What are the official names of this protein?
Lamin-B2.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Nucleus lamina.
Protein: NB2_MYCA1
Sequence: MPTDLHPDLAALAPLLGTWTGRGSGKYPTIQPFDYLEEVTFSHVGKPFLAYAQKTRAAADGKPLHAETGYLRVPQPGRLELVLAHPSGITEIEVGSYAVTGGLIEMRMSTTSIGLTPTAKEVTALGRWFRIDGDKLSYSVQMGAVGQPLQDHLAAVLHRQR
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase 2, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: CLRN2_MOUSE
Sequence: MPGWFKKVWYGLASLLSFSSFLLIIVALSLPHWLSGKILCQTGVDLVNATDPELVKFIGDIYYGLFRGCKVRQCGLGGRQSQFTIFPHLVKELNAGLHVTILLLLFLALALALVSMGFAILNIIQVPYRAVNGPGGICLWNVLAGGVVALAIGSFMAAVKFHDLTERIANFQERLFQFVVVEEQYEESFWICVASASAHAANLVVVAISQIPLPEIKTKMEEATVTPEDILY
What is the function of this protein?
Plays a key role to hearing function.  Required for normal organization and maintenance of the stereocilia bundle and for mechano-electrical transduction.
What are the official names of this protein?
Clarin-2.
What is the protein family that this protein belongs to?
Belongs to the clarin family.
What are the subcellular locations of this protein?
Cell projection, stereocilium membrane; Multi-pass membrane protein.
Protein: RR18_ILLOL
Sequence: MDKSKRTFRKSKRSFRRRLPPIGSGDRIDYRNMSLISRFISEQGKILSRRVNRLTLKQQRLITIAIKQARILSSLPFLNNEKQFERTESTPRTTGTRARKKKIGLLLN
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MSRB_STAAN
Sequence: MLKKDKSELTDIEYIVTQENGTEPPFMNEYWNHFAKGIYVDKISGKPLFTSEEKFHSECGWPSFSKALDDDEIIELVDKSFGMVRTEVRSEESNSHLGHVFNDGPKESGGLRYCINSAAIQFIPYEKLEELGYGDLISHFDK
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: VP26B_PONAB
Sequence: MSFFGFGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVGLALKNPNKRLEHQGIKIEFIGQIELYYDRGNHHEFVSLVKDLARPGEITQSQAFDFEFTHVEKPYESYTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTGPNVYHENVTIAKYEIMDGAPVRGESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEERRYFKQQEVVLWRKGDIVRKSMSHQAAIASQRFEGTTSLGEVRTPSQLSDNNCRQ
What is the function of this protein?
Acts as component of the retromer cargo-selective complex (CSC).  The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.  The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway.  The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins.  The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5.  May be involved in retrograde transport of SORT1 but not of IGF2R.  Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 26B, Vesicle protein sorting 26B.
What is the protein family that this protein belongs to?
Belongs to the VPS26 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Late endosome.
Protein: RRAB_PSEA6
Sequence: MSTEEQAEWFEFNQETVEALIEDGSDSTKPHTIEYHFAGDDFDVLEKAAVDAFKAGFEVGDAEELMLDDGGTIFCFDAVVERLLDVDLINADTVKLLAIAQKQNVQFDGWGTYFIES
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity B.
What is the protein family that this protein belongs to?
Belongs to the RraB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPSS1_METLZ
Sequence: MKCCDNIDARMVDETSINLDPIQVGGRLTPEAMKAMISWGDGYSVCDNCRKPFRLDYIEKPPLKDFHVDVAEWLGMAQARTVPGARRGFQQVAGTYVEKGDPVLIGALAHYTSYLSVELQKGIVREIPKTADNHITAEDTANRIEDVVREFGIAPKLLYIDHVDYQFGNMHDVKGIAKVAHQYDIPVLYNGVYTVGIMPVNGKDLGVDFIIGSGHKSMAAPAPSGILAATEERANEVFRTTQMEGDLTGRKFGIKEVGILGCSLMGAPIVGLLASFPTVKARVEHFDEELANSKIVVEALRFIEGTKILSEYPRKHTLTRVDTTGSFDQVAQTHKKRGFFLSSALGKKGITGIIPGATKVWKFNTYGMTKKQAEYVADTYLEIAETNGLTIN
What is the function of this protein?
Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
What are the official names of this protein?
O-phospho-L-seryl-tRNA:Cys-tRNA synthase 1, Sep-tRNA:Cys-tRNA synthase 1, SepCysS 1.
What is the protein family that this protein belongs to?
Belongs to the SepCysS family.
Protein: MCH_CARSF
Sequence: AKMSLSSYILILTLVLFSQGILLSASKSIRNLEDDMVFNTFRLGKAFQKEDTAEKSVVAPSLEQYKNDENS
What are the official names of this protein?
Pro-MCH.
What is the protein family that this protein belongs to?
Belongs to the melanin-concentrating hormone family.
What are the subcellular locations of this protein?
Secreted.
Protein: UPPP_SHEPW
Sequence: MDTFQVIILALIQGLTEFLPISSSAHLILPAQLLDWQDQGLSFDVAVNTGSLLAVVMYFRKELYSMFMAWTGSIASGKQTQESKLSWWIILATIPAVIVGFTAKGFIETYLRNIEVIAATTIIFGLLLWWADRMQRQGFNEFQVGWKKALVIGLAQAMALIPGTSRSGATITAALMLGLSREAAARFSFLMSVPVSLGAAILVTKDLLSSGQAIDYQALGLGIVVSFIAAYVCIHYFLKIISKMGMTPFVIYRLVLGAVLCGFIFL
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: XERC_PSEAE
Sequence: MRADLDAFLEHLRSERQVSAHTLDGYRRDLLKILALAEKAGLSDWNALDTRSLRTFVARLHQQGQSSRSLARLLSATRGLYQYLLREGRCRHDPANGLSAPKSPRKLPRTLDADRALQLLDGAVEDDFIARRDQALLELFYSSGLRLSELVGLDLEWLDLKEGLVRVRGKGNKVRELPVGKAARQALEAWLPLRTQAAPEDGAVFIGRSGKRLTPRAIQLRVRQAGVRELGQHLHPHMLRHSFASHLLESSGDLRAVQELLGHADIATTQIYTHLDFQHLASVYDRAHPRAKRKGNADGGNDP
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids (By similarity).
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCDA_STAAB
Sequence: MINKNDIVADVVTDYPKAADIFRSVGIDFCCGGQISIEAASLEKKNVDLNELLQRLNDIEQTNTPGSLNPKFLNVSSLIQYIQAAYHEPLREEFKNLTPYVTKLSKVHGPNHPYLVELKETYDTFKNGMLEHMQKEDDVDFPKLIKYEQGEVVDDINTVIDDLVSDHIATGQLLVKMSDLTSSYEPPIVACGTWRLVYQRLKALEVLTHEHVHLENHVLFKKVS
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein ScdA.
What is the protein family that this protein belongs to?
Belongs to the RIC family. ScdA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESXR_MYCBO
Sequence: MSQIMYNYPAMMAHAGDMAGYAGTLQSLGADIASEQAVLSSAWQGDTGITYQGWQTQWNQALEDLVRAYQSMSGTHESNTMAMLARDGAEAAKWGG
What are the official names of this protein?
ESAT-6-like protein EsxR.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. ESAT-6 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX-3 / type VII secretion system (T7SS).
Protein: PSTB1_VIBPA
Sequence: MFNFDNTLGYEPPLDVHNLTDEQTAISIENLNLFYGQAQALHDISMRIPKGRVTAFIGPSGCGKSTLLRCINRMNDLVEGCKVTGKVRLHGKNVYHPNVDVATLRRRVGMVFQRPNPFPKSIYENVVYGLRLQGVKNSRTLDDAVERSLRSAALWDEVKDRLHENAFGLSGGQQQRLVIARAVAIEPEVLLLDEPTSALDPISTLTIEELINELKTQYTVVIVTHNMQQAARVSDHTAFIHMGKLIEYSDADSIFTSPMKKQTEDYITGRYG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PPAC_BACC1
Sequence: MEKVLVFGHKNPDTDAICSAIAYAELKKELGMNAEPVRLGEISGETQFALDYFKVEGPRFVETVANEVDNVILVDHNERQQSANDIESVRVLEVIDHHRIANFETSDPIYYRCEPVGCTATILNKMYKENGITIRKEVAGLMLSAIISDSLLFKSPTCTEQDVAAARELAEIAGVDADNYGLEMLKAGADLSGKTMEQLISLDAKEFQMGNAKVEIAQVNAVDTNDVLVHQAELEKVISAVVEEKGLDLFLFVVTDILTNDSVGLAIGNAANVVEKAYNVSLENNTATLKGVVSRKKQIVPVLTEAFQA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_ACIBC
Sequence: MLIQRGGLKVVAGLGISGVSAVNFLHEQGYQVAVTDSRPTPPGHDQIPAGVKTSFGQLDQELLLQAEEIILSPGLAPQLPEIQAAIAKGISVVGDIQLLRRATDVPIVAITGSNAKSTVTTLIGLMAKDAGKKVAVGGNLGRPALDLLKDQPELLVLELSSFQLETTSHLNAEVAVVLNMSEDHLDRHGNMLGYHQAKHRIFQGAKKVVFNRDDALSRPLVPDTTPMQSFGLNAPDLNQYGVLRDADGTLWLARGLQRLIKSSDLYIQGMHNVANALACLALGEAIGLPMESMLETLKRFKGLEHRCEYVKTVRDVRYYNDSKGTNVGATLAAIDGLGAAIEVKKGKVALILGGQGKGQDFSPLRSSIEKYAKVVVLIGEDAPVIEQAIQGATKILHAATLKEAVELCQRETQAEDVVLLSPACASFDMFKSYNDRGQQFVACVNSLV
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINP1_HUMAN
Sequence: MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADLIQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKVLEYLNDLKQYWKRGYGYTINSRSSCTLFQDIFQHLDKAVEQKQRSQPISSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNYKKQMHRKFRSGLIVPYASNLIFVLYHCENAKTPKEQFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSCQTSEECELARANSTSDEL
What is the function of this protein?
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (PubMed:33257696).  Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate.  May play a role in bone development (endochondral ossification).  May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity).  Through the regulation of intracellular inositol polyphosphates, may control intracellular cation homeostasis, including that of calcium and iron, hence affecting free cation availability required for neural cell signaling (PubMed:33257696).
What are the official names of this protein?
Multiple inositol polyphosphate phosphatase 1, 2,3-bisphosphoglycerate 3-phosphatase, 2,3-BPG phosphatase, Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, Ins(1,3,4,5)P(4) 3-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family. MINPP1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: RSMG_SYNY3
Sequence: MSLNLDKDNRDLSSNQGHLGEFRRGLENWPPGLVWQPDGEQIEAMVKLYQGVLVGNARLNLTRITAPLDFLEKHLWDSLAGVLLSDHSRNCPQARVIDIGTGGGFPGLPVALVWPQWSVALLDSTHKKINYLEELGHRLGLANLAYLVARAEAVGNQPQHRSQYDLALIRAVGEGVVCAEYALPLVKVGGTVVLYRGQWSAAEAEQLERACALLGGKVSATVAAVTPWSGAQRHFIYLTKEKPTPSDFPRAIGVPRSHPLGVEN
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REP_ARATH
Sequence: MIDIPPYPPLDPSNYDLIVVGTGVSESVLAAAASSSGSSVLHLDPNPFYGSHFASLSLPDLTSFLHSNSVSPPPSPSSPPLPPSNNHDFISVDLVNRSLYSSVEISSFESEILEEHSRRFNVDLAGPRVVFCADESINLMLKSGANNYVEFKSIDASFVGDSSGELRNVPDSRAAIFKDKSLTLLEKNQLMKFFKLVQSHLASSTEKDDSTTVKISEEDMESPFVDFLSKMRLPPKIKSIILYAIAMLDYDQDNTETCRHLLKTKEGIDRLALYITSMGRFSNALGALIYPIYGQGELPQAFCRRAAVKGCIYVLRMPITALLLDKETGGYKGVRLASGQEIFSQKLILDPCVTVGLESLSSLTDQQNETLSVLVPKSMINKEKIARGVCVIRGSVKANVSNALVVYPPKSLFPEQLTAIRVLQLGSGLAVCPADMHVLYLSTLCDNDDQGIKALLSAMSNLISLPVPENRQSDSVVENDTSETKPILLWRALYVQELVKGEFGGTISSMPSPDGNLNYNEIVESAVKLYEKLMGSEELFKEETSPAENTTEEENDGGVEIED
What is the function of this protein?
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex.  Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component composed of the alpha subunit RGTA and the beta subunit RGTB (Probable).  Preferentially binds the GDP-bound form of Rab and stimulates geranylgeranylation of various Rab GTPases in vitro (PubMed:15854662).
What are the official names of this protein?
Rab escort protein 1, AthREP.
What is the protein family that this protein belongs to?
Belongs to the Rab GDI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_CAMJD
Sequence: MINALKGMKDLLDKDAYYYEKVIQTCEEVVKNYGFTFINTPHLELCILFKRSVGESSDIVGKEMYEFIDKGENHVCMRPEGTAGVVRAYIEKKLDKNTSVKRWFYHGSMFRYERPQKGRLREFHQFGVESFGNASVYEDASIILMLVEIFSRLDIKFKLLINSLGCLECMPKYRENLIHFLDSKEGFCEDCLRRKNLNPIRVLDCKNEHCQSLLNDAPLLNQNLCSSCQKDFEILQSVLKENGVDFEVDSKLVRGLDYYSKTAFEFISDEIGAKAAIAGGGRYDRLIEYLDGKSGFGIGFAMGIERIIAILEQKEEKVQREGIYLCAMDKIYIQKLLHIATNLRKEHKVLLSYEARKLAKHLENADKNNAEIFLCMGENEVQNESLFYKNLVKKEEKMIKISDLKKVL
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COF_ECOUT
Sequence: MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: VATB_STRPQ
Sequence: MSVLKEYRTVSEVVGPLMIVDQVAGVHYNELVDITLHNGERRKGQVLEVQGDKAMVQLFEGSTGINLAKTKVRFTGHPLELAVSEDMVGRIFDGMGQPIDGGPELIPEKYLDIDGQAINPVARDYPDEFIQTGISAIDHLNTLVRGQKLPVFSGSGLPHNELAAQIARQATVLNSDDNFAVVFAAMGITFEEAEFFMNDLRETGAIDRSVLFINLANDPAIERIATPRIALTTAEYLAYEKGMHVLVIMTDMTNYCEALREVSAARREVPGRRGYPGYLYTNLSTLYERAGRLIGKKGSVTQIPILTMPEDDITHPIPDLTGYITEGQIILSQELYKNGFRPPINVLPSLSRLKDKGSGEGKTRQDHAATMNQLFAAYAQGKQAKELAVVLGESALSETDKLYVAFTNRFEEEYINQGFYTNRSIEESLDLGWELLSILPRTELKRIKDDMLDRYLPKADTTMTKVFVAND
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.