PharMolix/UniProtQA huggingface dataset:
Protein: PSTB1_VIBVU
Sequence: MYSFNDTLGYHAPLDVNNLPDDKTAITIENLDLHYGQSQALYDISMRIPKGRVTAFIGPSGCGKSTLLRCINRMNDLVEGCKVTGSVKLYGSNVYDPSVDVATLRRRVGMVFQRPNPFPKSIYENVVYGLRLQGVKNSRTLDDAVERSLRSAALWDEVKDRLHENAFGLSGGQQQRLVIARAVAIEPEVLLLDEPTSALDPISTLTIEELINDLKTQYTVVIVTHNMQQAARVSDYTAFIHMGKLIEYSDADTIFTSPMKKQTEDYITGRYG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MURC_SYNFM
Sequence: MFKRYQHIHFVGIGGIGMSGIAELLLNLGYRVSGSDLKETEITRRLSAMGAAVHLGHRAEHVLGADVVVLSSAISDDNPENRAAREMGKVPVIRRAEMLAELMRLKYSVLVAGAHGKTTTTSMVSTVLARGGLDPTVVIGGKLNAWGTNAKLGNGDFMVAEADESDGTFLLLPPTIAVVTNIDLEHLDFYRDLAHIQETFLQFINKIPFYGQAVLCLEDENIQSILPRVEKRFTTYGFSSQADFQARDVRTSGLFSSYRVHSHGDELGEIEIRIPGRHNVLNSLAAVAVARELDLDWANIQDGLRDMTGVQRRFQIKGEAANVLVIDDYGHHPSEIRAVLQTLADCYPDRRRIVVFQPHRYTRTRALMEQFARCFYHSDVLLVTEIYAASETPIPGVTGERLSQEIASHGHHDLHFCETVESALSRLVKLVKPGDAVITLGAGNIWQVGEWLLAKLKSSGGSGGTGELK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_CAUVC
Sequence: MDRRVAAVGDLERRIGHRFEDRELLERALTHASVGDGAKKVRDNEVLEFIGDRVLGLLAAEALAQRFPKAKEGELAPRLNALVSRETCARVARKAELGPALRLSASSSKIGGRETDSILAGATEALMAALYQDGGLEAARKVFLDLWNDEFDRAGEGRPRDPKTALQEWAQGQGRPLPTYRVLDRTGPDHAPVFTVEVSVTGVDPAIAKGKSRQEAEKAAAKALLEREGAG
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_BURP1
Sequence: MARIAGVNIPNHQHTEIGLTAIFGIGRTRARSICVASGVAFSKKVKDLTDADLEKLREEVGKFVVEGDLRREVTMNIKRLMDLGCYRGVRHRKGLPLRGQRTRTNARTRKGPRRAAQALKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: ACTB1_DANRE
Sequence: MDEEIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMGTAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITSLAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells.  Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction.  In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
What are the official names of this protein?
Actin, cytoplasmic 1, Beta-actin-1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus.
Protein: DCD_NITEC
Sequence: MSIKSDKWIRRMAAEYGMIEPFEPGQVKQKDGHSIVSYGTSSYGYDIRCSDEFKLFTNLNSTIVDPKRFDSNSFVDLKNDICIIPPNSFALARTVEYFRIPRNVLTICLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVIFFEADEVCETSYKDRKGKYQFQQGVTLPKI
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: SYS_SHELP
Sequence: MLDPKFLRTELEATAERLATRGFILDVDRLSKLEEKRKSLQVATEELQASRNAISKSIGQAKAKGEDVAPIMAKVGDLGAELSSKEAELKQLLEELNAIAMSVPNLPDESAPIGADENDNVEIRRWGEPKQFDFDVKDHVDLGEQHAGLDFKSAVKITGSRFIVMKGQIARMHRALTQFMLDLHTTEHGYTETYVPLLVNEDSLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPLTNLARDTIIDEDELPIKMTAHTACFRSEAGSYGRDTRGLIRQHQFDKVELVQLVKPEDSMAALESLTQHAETVLQRLGLPYRTVVLCTGDMGFGAAKTFDIEVWLPAQNTYREISSCSNMQDFQARRMQARYKAKSAKKPALLHTLNGSGLAVGRTLVAVLENYQNADGSITVPEALRPYMGGLTQIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REGA_BPR51
Sequence: MIEITLKKPEDFLKVKETLTRMGIANNKDKVLYQSCHILQKKGLYYIVHFKEMLRMDGRQVEMTEEDEVRRDSIAWLLEDWGLIEIVPGQRTFMKDLTNNFRVISFKQKHEWKLVPKYTIGN
What is the function of this protein?
Controls the translation of a number of proteins (such as regA itself, rIIB and at least 35 others) by binding to their mRNA.
What are the official names of this protein?
Translation repressor protein.
Protein: PYRE_THEPX
Sequence: MEKEEVLEIFSKLGVINKGHFLLTSGKHSDTYLQCAKIFQYPKYSEIFSKELALKFKGHEIDVVIGPAIGGIILAYEVARQVGAKALFAEREEGVMKLRRGFEIKEGENVLVVEDVVTTGGSVKEVINLVNSLKGNVIGVGSIVDRSDGKVNFEVPFKSVVSLYVETYEKEECPLCKEGIPLVKPGSRKF
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: PSAN_CUCSA
Sequence: XVXEDYLEKSKANLELNDKKXXXT
What is the function of this protein?
May function in mediating the binding of the antenna complexes to the PSI reaction center and core antenna.
What are the official names of this protein?
Photosystem I reaction center subunit N, PS I subunit 9A, Photosystem I 7.6 kDa protein, PSI-N.
What is the protein family that this protein belongs to?
Belongs to the psaN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side.
Protein: DMGD_CHRSD
Sequence: MKIRDAYTIVTCPGRNFVTLKIVTESGTHGIGDATLNGREMAVAAYLDEHVVPALIGRDAGRIEDTWQYLYRGAYWRRGPVTMTAIAAVDMALWDIKAKAAGMPLYQLLGGKSRERVMTYAHCTGQTIEDCLGEVARHVELGYRAVRVQSGVPGIETTYGVAKTPGERYEPADSSLPAEHVWSTEKYLNHAPKLFAAVRERFGDDLHVLHDVHHRLTPIEAARLGKAVEPYHLFWLEDCVPAENQESLRLIREHTTTPLAIGEVFNSIHDCRELIQNQWIDYIRMPLTHGGGITAMRRVADLASLYHVRTGFHGPTDLSPVCLGAAIHFDTWVPNFGIQEHMPHTDETDAVFPHDYRFEDGHFLAGESPGHGVDIDEELAAKYPYERASLPVNRLEDGTLWHW
What is the function of this protein?
Has low dehydratase activity with D-mannonate and D-gluconate, suggesting that these are not physiological substrates and that it has no significant role in the in vivo degradation of these compounds.  Has no detectable activity with a panel of 70 other acid sugars (in vitro).
What are the official names of this protein?
D-galactonate dehydratase family member ManD, D-gluconate dehydratase, D-mannonate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: ERV15_YEAST
Sequence: MSGTGLSLFVTGLILNCLNSICQIYFTILYGDLEADYINSIELCKRVNRLSVPEAILQAFISALFLFNGYWFVFLLNVPVLAYNASKVYKKTHLLDATDIFRKLGRCKIECFLKLGFYLLIFFFYFYRMVTALLENDANLIS
What are the official names of this protein?
ER-derived vesicles protein ERV15.
What is the protein family that this protein belongs to?
Belongs to the cornichon family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y2053_YERP3
Sequence: MYPVDLHMHTVASTHAYSTLHDYIAEAKLKNIKLFAITDHGPDMADAPHYWHFMNMRVWPRLVDGVGILRGIEANIKNLDGDIDCTGPMLDAVDLLIAGFHEPVFPPQDKAANTQAMIATMAQGNVHIISHPGNPKYPVDIPAIAQAAAKYNVALELNNSSFAHSRKGSEANCRAIAAAVRDAGGWLALGSDSHIAYALGIFEHCERIIAEVNFPQERILNVSPRRLLDYLEQRGRPAIPELAEL
What are the official names of this protein?
Probable phosphatase YpsIP31758_2053.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: RS18_BORAP
Sequence: MYKDRDVNQRDSRFENQQDGFKKNSNFRFFKRKSCKFCDSGKHPDYKEFDFLKKFITEQGKILPKRITGTSAKHQRRLALEIKRARYMALLPFVKK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: MAO1_ARATH
Sequence: MGIANKLRLSSSSLSRILHRRILYSSAVRSFTTSEGHRPTIVHKQGLDILHDPWFNKGTAFTMTERNRLDLRGLLPPNVMDSEQQIFRFMTDLKRLEEQARDGPSDPNALAKWRILNRLHDRNETMYYKVLINNIEEYAPIVYTPTVGLVCQNYSGLFRRPRGMYFSAEDRGEMMSMVYNWPAEQVDMIVVTDGSRILGLGDLGVHGIGIAVGKLDLYVAAAGINPQRVLPVMIDVGTNNEKLRNDPMYLGLQQRRLEDDDYIDVIDEFMEAVYTRWPHVIVQFEDFQSKWAFKLLQRYRCTYRMFNDDVQGTAGVAIAGLLGAVRAQGRPMIDFPKMKIVVAGAGSAGIGVLNAARKTMARMLGNTETAFDSAQSQFWVVDAQGLITEGRENIDPEAQPFARKTKEMERQGLKEGATLVEVVREVKPDVLLGLSAVGGLFSKEVLEAMKGSTSTRPAIFAMSNPTKNAECTPQDAFSILGENMIFASGSPFKNVEFGNGHVGHCNQGNNMYLFPGIGLGTLLSGAPIVSDGMLQAASECLAAYMSEEEVLEGIIYPPISRIRDITKRIAAAVIKEAIEEDLVEGYREMDAREIQKLDEEGLMEYVENNMWNPEYPTLVYKDD
What is the function of this protein?
Involved in the regulation of sugars and amino acids metabolisms during the night period.
What are the official names of this protein?
NAD-dependent malic enzyme 1, mitochondrial, AtNAD-ME1, NAD-malic enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: REP1_MDV1
Sequence: MPTLQGTFWCFTLNFSGDAPSLSFNERVQYACWQHERVSHDHLQGYIQMKKRSTLKMMKELLPGAHLEVSKGTPEEASDYAMKEETRVAGPWTYGELLKKGSNKRKLLDRYKENPEDMELEDPAKARRCRAKIDKEKFIAEFKVEDDEQEWKKILEKEIEKIASPRSILWVYGPQGGEGKTSKAKELITRGWFYTRGGKKDDVAYSYVEDPTRHVVFDIPRDMQEYCNYSLIEMLKDRIIISNKYEPITNCQVYNIHVIVMANFLPDVTKISEDRIKIIYC
What is the function of this protein?
Initiates and terminates the replication only of its own subviral DNA molecule.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific hairpin at the genome origin of replication.  Introduces an endonucleolytic nick within the intergenic region of the genome, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities (By similarity).
What are the official names of this protein?
Para-Rep C1, Rep1, Replication-associated protein of non-essential DNA C1.
What is the protein family that this protein belongs to?
Belongs to the nanoviridea/circoviridae replication-associated protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: MSCL_SALPK
Sequence: MSFIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAFTLREAQGDIPAVVMHYGVFIQNVFDFVIVAFAIFVAIKLINRLNRKKAEEPAAPPAPSKEEVLLGEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: F172A_DROME
Sequence: MWSRLIQIFRPLRSFRMSHSPPPASNCEEALIQLKNFGYAFDGEGVLRKVDPATGEPGKELFSYNVSDDAAENEKHYQKLANQIPEIVYALLEKNGLSRTYIPFDQPPERSSFVFSQPAKLSQSKKLLVLIHGSGYVKAGQWARSLIINNSLDHGTQLPYVRQAQKLGYDLLITNANDCTRFYNGKENPIKGVNTSVEHVKYVWKNIVLPAKPESVAIVAHSYGGSLTLDLVERFPDFFKESVFAIAFTDAAMGSPQAKNKEYLCDVACDWVASNTPLDTPVSQSKSSIRRISAGHTKHEWTSYSAIDSVFKFIEEKYEQRANKK
What are the official names of this protein?
FAM172 family protein homolog CG10038.
What is the protein family that this protein belongs to?
Belongs to the FAM172 family.
Protein: FICD_DROYA
Sequence: MGTEAEQPSPPSPPAQQQEQTNPPLWNAQNQKPARLYRLVLFFIAGSLAAWTIHALSNSNLVWKLRQLHHLPTAHYLQTRDEFAVYSVEELNAFKEIYDKSVSDSVGASYTKDEQTSINEALVSLRMAQDMYLAGKDDKASRLFEHALALAPRHPEVLLRYGEFLEHSQRNIVLADQYYFQALTISPSNSEALANRQRTADVVQTLDERRLQSLDSKRDALSAIHESNGALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSILETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKIDITIKDILELHRRVLGHVDPIEGGEFRRNQVYVGGHVPPGPGDLALLMQRFERWLNSEHSSTLHPVNYAALAHYKLVHIHPFIDGNGRTSRLLMNTLLMRAGYPPVIIPKQQRNKYYHFLKLANEGDIRPFVRFIADCTEKTLDLYLWATSDLPQQIPMLIQTESEAGERLAQMQSPNVAQRSSILEFYESGSGALP
What is the function of this protein?
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity).  The side chain of Glu-250 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity).  Acts as a key regulator of the unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of Hsc70-3/BiP.  In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of Hsc70-3/BiP at 'Thr-518', thereby inactivating it.  In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from Hsc70-3/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity).
What are the official names of this protein?
Protein adenylyltransferase Fic, De-AMPylase Fic.
What is the protein family that this protein belongs to?
Belongs to the fic family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: RUVC_ACIAD
Sequence: MPLIIGIDPGSRLTGYGIIEKNGNELRFIDAGTIRTESQDMPERLKRIFAGVERIVKFHGPTQAAVEQVFMAQNPDSALKLGQARGAAIAALVNLDLEVAEYTARQIKQSVVGYGAADKEQVQMMVMRILNLTIKPQSDAADALAAAICHAHASGSMSKMAVLNALGGMARGRSRSSTRRR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: IFM3_HUMAN
Sequence: MNHTVQTFFSPVNSGQPPNYEMLKEEHEVAVLGAPHNPAPPTSTVIHIRSETSVPDHVVWSLFNTLFMNPCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTAKCLNIWALILGILMTILLIVIPVLIFQAYG
What is the function of this protein?
IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis.  Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes.  May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane.  Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33270927, PubMed:33239446).  Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927).  Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase).  Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.  In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436).  IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436).  Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane (PubMed:33270927).
What are the official names of this protein?
Interferon-induced transmembrane protein 3, Dispanin subfamily A member 2b, DSPA2b, Interferon-inducible protein 1-8U.
What is the protein family that this protein belongs to?
Belongs to the CD225/Dispanin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Early endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Cytoplasm, perinuclear region. Note=Co-localizes with BRI3 isoform 1 at the perinuclear region.
Protein: COX1_CERSP
Sequence: MADAAIHGHEHDRRGFFTRWFMSTNHKDIGVLYLFTGGLVGLISVAFTVYMRMELMAPGVQFMCAEHLESGLVKGFFQSLWPSAVENCTPNGHLWNVMITGHGILMMFFVVIPALFGGFGNYFMPLHIGAPDMAFPRMNNLSYWLYVAGTSLAVASLFAPGGNGQLGSGIGWVLYPPLSTSESGYSTDLAIFAVHLSGASSILGAINMITTFLNMRAPGMTMHKVPLFAWSIFVTAWLILLALPVLAGAITMLLTDRNFGTTFFQPSGGGDPVLYQHILWFFGHPEVYIIVLPAFGIVSHVIATFAKKPIFGYLPMVYAMVAIGVLGFVVWAHHMYTAGLSLTQQSYFMMATMVIAVPTGIKIFSWIATMWGGSIELKTPMLWALGFLFLFTVGGVTGIVLSQASVDRYYHDTYYVVAHFHYVMSLGAVFGIFAGIYFWIGKMSGRQYPEWAGKLHFWMMFVGANLTFFPQHFLGRQGMPRRYIDYPEAFATWNFVSSLGAFLSFASFLFFLGVIFYTLTRGARVTANNYWNEHADTLEWTLTSPPPEHTFEQLPKREDWERAPAH
What is the function of this protein?
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Subunits 1-3 form the functional core of the enzyme complex.  Co I is the catalytic subunit of the enzyme.  Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B.  This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome aa3 subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYGA_ENT38
Sequence: MQKFDTKTFQGLILTLQDYWARQGCTIVQPLDMEVGAGTSHPMTSLRALGPEPMATAYVQPSRRPTDGRYGENPNRLQHYYQFQVVIKPSPDNIQELYLGSLKELGVDPTIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPITGEITYGLERLAMYIQGVDSVYDLVWSDGPLGKTTYGDVFHQNEVEQSTYNFEYADVDFLFTCFEQYEKEAQQLLALETPLPLPAYERILKAAHSFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCNRNK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PENH_STREX
Sequence: MTDTLSDYVDCTPLLDDREALDRFYDEHGYVYLRGALDRELVRTAAEQMLEGLIALGHADPATTLDTLTIDSFEAVDEVAMHDYVKYDDLWNHPSTLKVWEKVLGEPVFVFKSTTIRYYPSAAGSAEPSFLTPLHQDGFYIGPNKDFRTAWIPLLPTSHGIGGVAVADGSHKKGPREHVVTEQFRRFGHAVRGIPAEEFGTDEQLLFSPMEPGDVLIFHAFMCHKSIPNVSANPAGMRMSMDTRIQPASSHRGFNALTPWPESAKDASKGILSKITGTPTTAE
What is the function of this protein?
Catalyzes the conversion of 1-deoxypentalenic acid to 11-beta-hydroxy-1-deoxypentalenic acid in the biosynthesis of pentalenolactone antibiotic.
What are the official names of this protein?
1-deoxypentalenic acid 11-beta-hydroxylase, Pentalenolactone biosynthesis protein H.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: MNTP_BACC3
Sequence: MTFEQLIPLIIMAFALGMDAFSVSLGMGMMALKIRQILYIGVTIGIFHIIMPFIGMVLGRFLSEQYGDIAHFAGAILLIGLGFYIVYSSILENEETRTAPIGISLFVFAFGVSIDSFSVGLSLGIYGAQTIITILLFGFVSMLLAWIGLLIGRHAKGMLGTYGEIVGGIILVGFGLYLLFPI
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DCTP1_RAT
Sequence: MSQAGTGVCGNGGQEDSAAAGPFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKSDAEPGPQAWQPKERAALQEELSDVLIYLVALAARCHVDLPRAVISKMDTNRQRYPVHLSRGSACKYTDLPRGTLSENEAVGSGDPASELGNQAST
What is the function of this protein?
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates.  Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency.  May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
What are the official names of this protein?
dCTP pyrophosphatase 1, Deoxycytidine-triphosphatase 1, dCTPase 1, RS21-C6.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Note=May also localize to mitochondrion and nucleus.
Protein: PHAA_MASLA
Sequence: SIVTKSIVNADAEARYLSPGELDRIKSFVSSGEKRLRIAQILTDNRERIVKQAGDQLFQKRPDVVSPGGNAYGQEMTATCLRDLDYYLRLITYGIVAGDVTPIEEIGIVGVREMYKSLGTPIDAVAAGVSAMKNVASSILSAEDAAEAGAYFDYVAGALA
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex.  Allophycocyanin has a maximum absorption at approximately 650 nanometers.
What are the official names of this protein?
Allophycocyanin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Forms the core of the phycobilisome.