PharMolix/UniProtQA huggingface dataset:
Protein: CERS1_HUMAN
Sequence: MAAAGPAAGPTGPEPMPSYAQLVQRGWGSALAAARGCTDCGWGLARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPESAWKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFFFNALLLLLTLMNLYWFLYIVAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAEKPLRNGLVKDKRF
What is the function of this protein?
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624).  N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624, PubMed:24782409).  Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity.  Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way (By similarity).  Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function (By similarity).  In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging.  Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria (PubMed:22922758).
What are the official names of this protein?
Ceramide synthase 1, CerS1, LAG1 longevity assurance homolog 1, Longevity assurance gene 1 protein homolog 1, Protein UOG-1, Sphingoid base N-stearoyltransferase CERS1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TRPC_ALIB4
Sequence: MILDEIIEKTKEDLILRKEKLNFEELEKKLKTINSKPKDVKTFLKSTKEEPIRIIAEVKKASPSKGIIKEDFNPLEIALEYSQNGANAISVLTEPHYFKGNLEYLSTIKNSVSTPLLRKDFIVDKYQIAEALLYGADFILLIAKALNEKELKELYEYARSLDLEVLVEIHDNEDLTKALNSNATIIGINHRNLGTFEMDMALCDKLIPLIPKDKIIVAESGVSDTEVIKRLHNVGADAFLIGEHFMRVPSIKDELTKFKNTLN
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: PYLS_METBF
Sequence: MDKKPLDVLISATGLWMSRTGTLHKIKHYEVSRSKIYIEMACGDHLVVNNSRSCRTARAFRHHKYRKTCKRCRVSDEDINNFLTRSTEGKTSVKVKVVSAPKVKKAMPKSVSRAPKPLENPVSAKASTDTSRSVPSPAKSTPNSPVPTSAPAPSLTRSQLDRVEALLSPEDKISLNIAKPFRELESELVTRRKNDFQRLYTNDREDYLGKLERDITKFFVDRDFLEIKSPILIPAEYVERMGINNDTELSKQIFRVDKNLCLRPMLAPTLYNYLRKLDRILPDPIKIFEVGPCYRKESDGKEHLEEFTMVNFCQMGSGCTRENLESLIKEFLDYLEIDFEIVGDSCMVYGDTLDIMHGDLELSSAVVGPVPLDREWGIDKPWIGAGFGLERLLKVMHGFKNIKRASRSESYYNGISTNL
What is the function of this protein?
Catalyzes the attachment of pyrrolysine to tRNA(Pyl).  Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
What are the official names of this protein?
Pyrrolysine--tRNA ligase, Pyrrolysine--tRNA(Pyl) ligase, Pyrrolysyl-tRNA synthetase, PylRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EI3D2_DROGR
Sequence: MSQYAPFVKPYIEYNEFGWGPSDLPDLEVPYQPFCKGDRLGKISDWTTPVQERKYNNNKYMSTFGSSNSQYAYFHGNDDASFHLVNGNNMRALKPYQRNRYRPTQRNNLRLHGRNGRFNAAIGAGHGGAGAAGGAGASNKYGKGRDMRRGQTGRRFMRAAPVRQRQSSVVVRSDWVSIEEIDFPRLLKLTLPNIQEGADLITCGTLEFFDKQCDRINVKNERPLQKIDRIINVPGTIDDPIIRRLSKSLGNVFATDDIIATLMCCTRSNYSWDIVIDKVGTKLFLDKRDNAQFDMLTVNETALEPPLEEEGSINSPQSLSLEATIINHNFSQQVLKIGELEPKHKFDEPNPFEEPGVELASIGYRYKQWQLGDDMVLVARCKHNGVLRSPGGELQFLSIRALNEWDSKAANSVEWRQKLDSQRGAVLASELRNNACKLAKWTVEAVLAGSDQLKLGYVSRLNRKDHLHHVILGMQQFKPQEFATQINLNMDNAWGVLRCLVDIMLKQPDGKYLIMKDPNKPMIRLYDIPENAFDSDNNDGEETSDDRPFLNSKDNKL
What is the function of this protein?
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit D-2, eIF3d-2, Eukaryotic translation initiation factor 3 subunit 7-2.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_RICAH
Sequence: MAVPKKKTSKSRRNMRRSHLALGKVNVIVDSQTGEYKLPHHVSLVDGTYNNRQVVTKRIETEEAVA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: SRRT_DROPE
Sequence: MADSDDEYDRKRRDKFRGERESYRTERRDERRPIGGAGGGRDEWSERNPFRGGGAGGGGAPRHRPDYSDYRGPGPRARYGSPVRDMPPPKRMRSDWGDGDGRPGPRYGGYDPYLMQAWTDHYQSMHSAYHHASHPPPVRELPIIGGDTLTQPAMLNLKQFLDTQDENISDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVNRSEEQRGFLRRRTDVFVELLENGTIGSVKVDSSHGDALIRVLDTCVIKLEGGTDEDLKVLDEKPKEALVFDRKPESVDPTTVVENTPKSPKKEKEEDELPLIVSPQRIALKPVNSDDENWDDAEVEDAPPKKPEEEEPKESEPIPEIKQKQKKEKKKKIKKRKRNSSSDEESSSSESESSSSSSEEEEEDDEKLKAKYDVEDGLRAEQKAEAEKDQAEAAKAKLGSVSPKEEISPEKSAADPEVEGEAKEDGKQAEKSPKSDDEKKQENGDAAKVESAAEPATGDAQGEVKPVTIDLDKVNPPRDMHRTSSIFLRNLAPSITKAEIEALCSRFSGYLRTAIADPLVERRWYRRGWITFTRDVNIKEICWSLNNQRLRDCEMGAIVNRDLSRRVRPANGITAHKQVVRSDIKLCARIVMNLDEKFKLWSEGPLSKPSPASDSEATAANGSGSSYGFNSKNPVLQNITDYLIEEASAEEEELLGLSGDRKDGEGEPIERDEQLLSVLDRLVLYLRIVHSVDYYNHCEYPYEDEMPNRCGIIHARGPAPSRVTSNELNEYIKSYEGKLLQFLTKTALLSEDQIKDLGAKNADTEVEKFVQANTQELAKDKWLCPLSGKKFKGPEFIRKHIFNKHEEKVDEVRKEVQYFNNYLRDPKRPQLPEHPGSVKRPETESVRGPGGYRPPMYTPMSGMPYSFGGHMMGGGRGGRHFPPARRELPLEHHRRLVGYHDLDAPSNSDIFD
What is the function of this protein?
Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi).  Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha (By similarity).
What are the official names of this protein?
Serrate RNA effector molecule homolog, Arsenite-resistance protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the ARS2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSAC_SOLLC
Sequence: MSHSVKIYDTCIGCTQCVRACPTDVLEMIPWDGCKAKQIASAPRTEDCVGCKRCESACPTDFLSVRVYLWHETTRSMGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RPOC_NEIG2
Sequence: MNLLNLFNPLQTAGMEEEFDAIKIGIASPETIRSWSYGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECLCGKYKRLKFKGVTCEKCGVEVTLSKVRRERMGHIELAAPVAHIWFLKSLPSRLGMVLNMTLRDIERVLYFEAFVVTDPGMTPLQRRQLLTEDDYYNKLDEYGDDFDAKMGAEGIRELLRTLDVAGEIEILRQELESTGSDTKIKKIAKRLKVLEAFHRSGMKLEWMIMDVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELHAPDIIVRNEKRMLQEAVDSLLDNGRRGKAMTGANKRPLKSLADMIKGKGGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIFHKLEKQGLASTVKAAKKLVEQEVPEVWDILEEVIREHPIMLNRAPTLHRLGIQAFEPILIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQMEARTLMLASNNVLSPANGEPIIVPSQDIVLGLYYMTRDRINAKGEGSLFADVKEVHRAYHTKQVELGTKITVRLREWVKNEAGEFEPVVNRYETTVGRALLSEILPKGLPFEYVNKALKKKEISKLINASFRLCGLRDTVIFADHLMYTGFGFAAKGGISIAVDDMEIPKEKAALLAEANAEVKEIEDQYRQGLVTNGERYNKVVDIWGRAGDKIAKAMMDNLSKQKVIDRDGNEVDQESFNSIYMMADSGARGSAAQIKQLSGMRGLMAKPDGSIIETPITSNFREGLTVLQYFIATHGARKGLADTALKTANSGYLTRRLVDVTQDLVVVEDDCGTSDGFVMKAVVQGGDVIEALRDRILGRVTASDVVDPSSGETLVEAGTLLTEKLVDMIDQSGVDEVKVRTPITCKTRHGLCAHCYGRDLARGKLVNAGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAASQVEAKSNGTARFSSQMRYVANNKGELVVIGRSCEVVIHDDIGRERERHKVPYGAILLVQDGMAIKAGQTLATWDPHTRPMITEHAGMVKFENMEEGVTVAKQTDDVTGLSALVVIDGKRRSSSASKLLRPTVKLLDENGVEICIPGTSTPVSMAFPVGAVITVREGQEIGKGDVLARIPQASSKTRDITGGLPRVAELFEARVPKDAGMLAEITGTVSFGKETKGKQRLIITDVDGVAYETLISKEKQILVHDGQVVNRGETIVDGAVDPHDILRLQGIEALARYIVQEVQEVYRLQGVKISDKHIEVIIRQMLRRVNIADAGETGFITGEQVERGDMMAANEKALEEGKEPARYENILLGITKASLSTDSFISAASFQETTRVLTEAAIMGKQDELRGLKENVIVGRLIPAGTGLTYHRSRHQQWQGVEQETAETQVTDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RECO_PSYIN
Sequence: MSIECHNAFILHRRPYRETSQLIDLFCQDVGKVSLVYKGGRSSTRMRRGTAQPFTLLQVSYFGRGSLKTVKSFEAQTQVVPLVGQRLFLAMYINELLYRLLQAETACDGLFECYQQTLLAIAGAVDPQIALRLFELTLIETLGYGVNFSEDIYSGELIESGYEYQYQHQAGFFAKQAIHKQHDVYSGQDILALAQRDFSNQNVLKSAKRFCRQALANLLGGKPLHSRALFTAK
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: MUKB_HAEIG
Sequence: MSDVFELENEIELESDEVIMENENVEEIVDAPIPFSMTTNNGVERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAGFVTALIPDLTLLHFRNTTEAGSTGGSRDKGLHGKLRPGVCYAVLDTINSRHQRILVGVRLQQIAGRDKKVDLKTFSIQGVELSQNPTALFTETVGERQARVLNLNELKDKIENIGAQFKQYHSITDYHGMMFDLGIIPKRLRSASDRSKFYKLIEASLYGGISSAITRSLRDYLLPENLGVRKAFQDMESALRENRMTLEAIKVTQSDRDLFKHLITETTNYVASDYMRNANERRGNIEAALESRREWYKAKAEQNLSQHRLVDLSREAAELAENERTLEVDHQSAVDHLNLVLNALRHQEKITRYQEDIAELTERLEEQKMVVEDANDALEESQAQFEQTEIEIDAVRAQLADYQKALDAQQTRALQYQQAIAALEKAKTLCGLADLSVKNVEDYHAEFEAHAESLTETVLELEHKMSISEAAKSQFDKAYQLVCKIAGEMPRSAAWESAKELLREYPSQKLQAQQTPQLRTKLHELEQRYAQQQSAVKLLNDFNQRTNLSLQTAEELEDYHAEQEALIEDISAGLSEQVENRSTLRQKRENLTALYDENARKAPAWLTAQAALERLEQQSGETFEHSQDVMNFMQSQLVKERELTMQRDQLEQKRLQLDEQISRLSQPDGSEDPRLNMLAERFGGVLLSELYDDVTIEDAPYFSALYGPSRHAIVVRDLNAVREQLAQLEDCPDDLYLIEGDPTAFDDSVLSAQELELGVVVQVSDRELRYSRFPEIPLFGSAAREKRLEELQIERDEVAEQHAQIAFDVQKYQRLHEHFSQFVGLHLALAFQPNPEALMSEINRERNEIDRELNQFNNGEQQLRIQLDNAKEKLQLLNKLIPQLNVLADEDLIDRIEECREQLDIAEQDEYFIRQYGVTLSQLEPIANSLQSDPENYEGLKNELTQAIERQKQVQQRVFALADVVQRKPHFGYEDAGQAETSELNEKLRQRLEQMQAQRDTQREQVRQKQSQFAEYNRVLIQLQSSYDSKYQLLNELIGEISDLGVRADDGAEERARIRRDELHQQLSTSRQRRSYVEKQLTLIESEADNLNRLIRKTERDYKTQRELVVAAKVSWCVVLRLSRNSDMEKRLNRRELAYLSADELRSMSDKALGALRTAVADNEYLRDSLRVSEDSRKPENKVRFFIAVYQHLRERIRQDIIKTDDPIDAIEQMEIELSRLTAELTGREKKLAISSESVANIMRKTIQREQNRIRMLNQGLQNIAFGQVKSVRLVVNIRDTHAMLLDALSGQQNEYQDLFNDNRITFSEAMAKLYQRINPHIDMGQRTAQTIGEELLDYRNYLELEVEVFRGADGWLRAESGALSTGEAIGTGMSILLMVVQSWEEESRRIRGKDIVPCRLLFLDEAARLDGKSISTLFELCERLDMQLLIAAPENISPEKGTTYKLVRKIAGNQEHVHVVGLRGFGATE
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: QUEC_CAMJJ
Sequence: MSKKALCIISGGMDSTLCAYLAKKEGYEIIALHFDYEQRTQEKEKECFKQICKALKVEKSYILDVSFIKDIGGNALTDKSIDIPKNELCISDVPPITYVPFRNGIFLSIAGSLAEKENCESIFIGVVEEDGSGYPDCTDEFIQKAQEFINEGTSKNFKVCIKTPLVRLNKAKIVELALKENVPLELTWSCYESEDEACGECDSCLLRLRGFEKAGFKDKIKYKS
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: CONG1_LUPAL
Sequence: MAKNMAPILHILVISLSYSFLFVTSSSQNSQSLYHNSQPTSSSKPNLLVLPIQQDASTKLHWGNILKRTPLMQVPVLLDLNGKHLWVTCSQHYSSSTYQAPFCHSTQCSRANTHQCFTCTDSTTSRPGCHNNTCGLISSNPVTQESGLGELAQDVLALHSTHGSKLGSLVKIPQFLFSCAPTFLTQKGLPNNVQGALGLGHAPISLPNQLFSHFGLKRQFTMCLSSYPTSNGAILFGDINDPNNNNYIHNSLDVLHDMVYTPLTISKQGEYFIQVSAIRVNKHMVIPTKNPSMFPSSSSSSYHESSEIGGAMITTTNPYTVLRHSIFEVFTQVFANNVPKQAQVKAVGPFGLCYDTKKISGGVPSVDLIMDKSDVVWRISGENLMVQAQDGVSCLGFVDGGVHTRAGIALGTHQLEENLVVFDLARSRVGFNTNSLKSHGKSCSNLFDLNNP
What is the function of this protein?
Sulfur-rich seed storage protein that remains undegraded at germination (PubMed:11406286).  The uncleaved form exhibits some inhibitory activity against GH11 xylanase from T. longibrachiatum, more at pH 7 than at pH 5. 3, but not against GH12 xyloglucan-specific endoglucanase (XEG) from A. aculeatus (PubMed:26741537).  Binds to model phospholipid membranes containing dimyristoyl phosphatidylglycerol (DMPG), dioleoyl phosphatidic acid (DOPA) or mixture of dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol (DMPC:DMPG), or mixture of dioleoyl phosphatidic acid and dioleoyl phosphatidylcholine (DOPC:DOPA) (PubMed:30312772).
What are the official names of this protein?
Gamma conglutin 1, Conglutin gamma 32.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space. Note=Present in the extracellular spaces of germinating cotyledons and in the young roots.
Protein: RNFH_COXBR
Sequence: MISIIIAYATPEKQVEIPLTVEESCTLVVAVKRSGILQQFPEINLSQAIVGIHNKRTALDAGLRDDDRIEIYRPLTMDPKQARLLRAKRGKIRRMVRGEAG
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: YIPC_SCHPO
Sequence: MALDEKFQLEVIHLLLQFLNDYGYDESLKALEKETGLVSETEDVKRLKQAVLQGDWITAEAAFSIMQLRDESKRKEAQFLLQKQRCLELARSGAICEAIYVLQNFESTDFNKEKERLVSIILESNNKSNNELITKNGYGNTRLDLLNQLSEYISPEILLPKRRLEHLLQQAKDYQVSSQVYHNVLKNFSFLSDYKADPSELPTKEYHVFHDHSDEVWQISYSHNGRYLASASKDKTAIIFDVVNLKRVFRLIGHIDTVAYIRWSPDDRYLLSCSCDKSVILWDAFTGEKLRDYKHGFSVSCCCWLPDGLSFITGSPDCHITHWSLNGEILYKWEDVNIYDMALTSDGTKLYIVGFEQLINAEDKHIAIYSVETRECIKKISLQSKVTSICLSKDSKYALTNLEPHTTFLWDLEENRIVRQYMGHKLGNFLIGSCFGGKDDTFVLSGSEDDKIRIWHRESGKLLATLSGHVKCVNYVAYNPVDPYQFASAGDDNTVRIWSNKDNPRRQ
What are the official names of this protein?
Uncharacterized WD repeat-containing protein C343.04c.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DCD_NEIMF
Sequence: MSIKSDKWIRRMSEEFGMIDPFEPNQIKEADGKRIISYGTSSYGYDIRCANEFKIFTNINSTIVDPKNFDPKNFVTVEDDCCIIPPNSFALARTVEYFRIPRNVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYAGEGVAQVLFFESDEICKTSYKDRNGKYMGQTGVTLPKA
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: MTNN_YERP3
Sequence: MKVGIIGAMEEEVTLLRDRIENRQTLARAGCEIYTGQLNGIDVALLKSGIGKVAAAMGTTLLLEHCQPDLVINTGSAGGLASSLKVGDIVVSNEVRYHDADVTAFGYEPGQMAGCPAAFVADEDLIALAENCIQQLKLNAVRGLICSGDAFINGAEPLARIRAAFPTVAAVEMEAAAIGHVCYLFNTPFVVVRAISDVADQASHLSFEEFLVVAAKQSTLMIEAMLTTLAQRG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: Y3709_BACCZ
Sequence: MASETVSNHQEKALALLQADAEKILRLIKVQMDHLTMPQCPLYEEVLDTQMFGLSREVDFAVRLGLIAEEQGKAMLGELERELSALHEAFTNKQQ
What are the official names of this protein?
UPF0358 protein BCE33L3709.
What is the protein family that this protein belongs to?
Belongs to the UPF0358 family.
Protein: SYP_TROW8
Sequence: MITKVSDFLFRTFREDPATTESRGYGFLLRAGYIRQTGSGIFSWMPLGLKVRHKIENIIRYEMRQVNAIEVLFPALFSADLFKQSGRWSEYGDDIFRLKDRRQGDYLLAPTHEEAFTQMMKEICTSYRDLPRTVYQIQDKYRDELRPRAGLLRSREFSMKDAYSFDLDEKGLRQSYEAQKRAYKKIFDRLEIDYVIVKANAGAMGGSVSEEFLHPTEMGDDTFVVTADGSAFNAEVYVTLPGPAIDYSNAPEAEDCETPGVISIPDLVNHMNSSGRFIGRVIESSDCLKCLLFRIEYAEVQNGNPGNLVVKKILERGFEYIGFLVPGDRNVDLKRAQVALSPLTIEPADNRVFECNPSFVRGSIGPGLSGVFYCADPRVSSGSSWIIGANRPGVHRIGAIAGRDFSFDCTLDVSSIKTGDKSEWGPVTVKRGIEIGHLFQLGLKYSNALGLKVLDKDGYNKAVFMGSYGIGVSRLFALIAEKNCDERGLKWPAVLAPFDLHVVLLSSARAELIDSLTDCGLDVLVDDRRVSPGVKFTDAQLIGVPKIIVIGDKTRGEDVEVWDRANDQRTVLPLKEMIQGVIQRSDTGGCTERCTGVCPTR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC6_APHFL
Sequence: ADTVSGAALFKANCAQCHVGGGNLVNRAKTLKKEALEKYNMYSAKAIIAQVTHGKGAMPAFGIRLKAEQIENVAAYVLEQADNGWKK
What is the function of this protein?
Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis.
What are the official names of this protein?
Cytochrome c6, Cytochrome c-553, Cytochrome c553, Soluble cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PetJ subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid lumen.
Protein: RLMN_ACIB5
Sequence: MSSAVVVSSENLDGQQQSSSTPASPAAEKVNLLGMSRAELEKFFEDIGEKKFRAGQVMKWIHQYFVTDFAEMTNISGKLRAKLEQICEIKAPEVVHRHYSKDGTRKWVFRVGEGSGSLVETVLIPAEDKTGSRKTLCISSQVGCALDCSFCSTGKQGFQRDLTPDEIIGQLWMANYSYMEEVPVAERERSVTNVVMMGMGEPLLNYDAVLSSMHIMLDDFAYGMSKRRVTLSTSGVVPKIDQLAKDIDVALAISLHAPNDELRNELVPINKKYPLAQLIAACQRYIAKDGNESARKHVTIEYVMLEGVNDQPEHAQQLLKLLKNLPSKINLIPFNPFPHAPYGRSSRNRIISFQKTLSDAGFVCTIRQTRGDDIDAACGQLVGQVADRTRRAEQWQKKVAQRQEILRTQG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOI1_SOLUE
Sequence: MANPIEEILGTAAAIAKGMGITFKEMMGPTVTDDYPDAPPKFEERFRGVHVLQRDVNGMEKCVACFLCAAACPSNCIYIEAAENTDKIRMSGGERYAKVYNIDYNRCIFCGYCVEACPTDAITHGHGFEAASYNTSTLVKRKEDMLVPVPPGAKPPSMADEVPAGAH
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I 1, NADH dehydrogenase I subunit I 1, NDH-1 subunit I 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ASZ1_SAIBB
Sequence: MATSALRGLAVAGGGESSESEDDGWEIGYLDRTSQKLKGQMLPIEEKKEKFKKALTTGDVSLVQELLDSGIISVDATFRYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQTILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVASGAEVNTQDENGYTALTWAARQGHKSIVLKLLELGANKMLQTKDGKLPSEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEETICKILTTDSDRENDHIFSSYAEFGDLEVFLHGLGLEHMTDLLKERDITLRQLLTMREDEFTKNGFASKDQQKILAALKELEVEEIQFGELSEEAKLEISGDEFLNFLLKLNKQCGHLITAVQNIITELPVNSQKIALEWASPQNFTSVCEELVNNVEDLSEEVCNLKDLIQKLQNERENDPTHIPLREEVSTWNSRILKRTAITVCGFGFLLFICKITFQRK
What is the function of this protein?
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.  Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process.  Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons.  May act by mediating protein-protein interactions during germ cell maturation (By similarity).
What are the official names of this protein?
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1, Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By similarity).