PharMolix/UniProtQA huggingface dataset:
Protein: STU1_ASHGO
Sequence: MEEPRVHNLEKLMDEGVAGIEQLQILTAFKTHVKKELVRDDSIERYFDALVRFLGQPVEDRKVQQLGHSSLCYLIKRVAMQQPGRFQGARIRDLVRVVLLQEQLQERKVWGSAVKSLEAIYLCKPQAFEAELASICAATRGSDRTKCLLFMDELIQLQQMNNRNPMEVVNRFVDLWVDVLNESDPGCSKRDIELIHDILKKYFNEAMLQQFAERVVNTRSLKHFMHTEHAAPSSAQTTSSMPSGPFDVDEELTRVMEELPPNVVNSNIGEARDYLSFEHVVKDLEHITVAFQAIKETEHNWKQRQEGIITLRKIVNGNVSRQFPDEFIQACRDLNIADCISKAALSLRTTLSSHSCHLIKEMAFKLGPLLEPLLDVLFVPLRSLLSATKKISSQTAFATAAILLCTAPYHNRLFQQCIALSRDKNVSPRTFAAVFLRIYIIRFHRRLEHSSVLVEEWLHKGLTDPQTQVREAMRVTLWYWYVPNAQSAKKVLDSMPHQMKRIIEGSIPTYLNIEYHVTASVSSNESSRRSSFGVRRYPSYAAPTQSSNLQKLAANSLGGSANVRSLSENTNRHLTTYTSLAKKSLATRHESLSPRVASSGLISSAGAANLSSENLELTEELTSNHSNTLLKKYLNTNEPAVIRKSEGEPTGDLESMYSHLSSTTLQEKQQGLLFLKNLLLLKAPLDIAKLNPLLVQLSIQSPKSFKDLLTLASFHPLIPLANLIELFAINDLPTNVLLDEFSSTDLLETVIHSFQTFFPDHHDQLFLYYVKYRSVIFNYCFGIMIDLLSGDFAFSEGSTLFREVCTRIIEACGNDFNMEKYYTLISILYRADKSQFVELLRDAPVSSKFKIANELQRCDSTFNLHSIMSRESTAESHHSDPNQQYKDGAHGGDARDANGTSNSSSDSDNEPDLESTKHLLEMTMVNPIGLGCVENVLQSHIHAYKQDQQHQDPIAEKSLSTVAEVNDEDGDGSTTTQMKLMGANTTEPSNESDKDKTSDIVAESMRGTDDPNYAKLCAIDSALIDSEDEPELNNFGGLKGLTEMTKVVSIYEKLDGDEDVEMVDDEKFKDPVEQENQETGLDEIFRDEKHDQSVKFNDIPRIIDVNKSWDRYDGESIEDTSGNTSHGTDENRPASFGTVSELVRKEMEKSPTLPLNEEDSKLLSDGINEIELKHKDDPFVRDSEDCENGTPQDRSNFLSCKQHIDILGALPDNSLTAFELGLLEILDVSDMDANRILETVNTIQNSRLRSADVSRIVGAIVSHCTDPLLHWLTDSNGLQRLWSMLTALSTADGFSDSYKCVVLYTALLIANSQLSSSHLSTDELSDAWAFALRELSKLSSYNNETYIACCELRETLIEHYSSSYLPQLLESAIKELNVAEDRVRITFLLQTLSDALDHMNTLLSLEVLGSMSSLLQQFVTNDFTEWRYHSIKLLAQIYGILVARNSPASYIRSMFSILRQPEFDLVKSYYTMDHN
What is the function of this protein?
Microtubule binding protein that promotes the stabilization of dynamic microtubules.  Required for mitotic spindle formation (By similarity).
What are the official names of this protein?
Protein STU1.
What is the protein family that this protein belongs to?
Belongs to the CLASP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.
Protein: CLPX_XANOP
Sequence: MSEDRQGRSGDSNKILYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREELEEKAQSARSSLPKPREILEVLDQYVIGQLRAKRTLAVAVYNHYKRIESRSKNDDVELAKSNILLVGPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQQGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVDTKNILFICGGAFAGLDKVIQQRSNDAGGIGFGVKVKSSERKQEVGKILAEVEPEDLIKFGLIPEFVGRLPVVATLEELDEPALIKILTEPKNAITKQFKKLFDMEGVELEFRADALSAIAKKALKRKTGARGLRTIVESVLLDTMYELPSQENVSKVVVDESVIEHKSEPYLIYQAQPAPAKAASGD
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: GATE_METMP
Sequence: MDYDYEKLGLKVGLEIHQQLNTKRKLFCNCPTKIRDDEPHGEIERVLRPSQSEMGHVDKAALLESKKEKKFIYQYYNDTTCLVELDDEPPHDVAPEAVDTALEVSTLMNMKMADEVQIMRKMVIDGSNTSGFQRTMFVSQEGFIETEYGNIGVTSLCLEEDACKKIEDGKDYTKYCVDRLGIPLLEITTEPDITSPKMGKEAARRIGTILRATGKVKRGLGTIRQDVNISIKNGARIEVKGVQNLDLIEKIIENEVTRQISLNEIKEELLKRNAEVVDEIKDITELLKDTESKVLKNALKNKGVIRAILLKGFSGMIGREVQPGRRLGTEFSDRGKVLGGVGGLFHTDELPKYGITEEEVIKLKEYMNCGENDAVILVADKKNKVERALNAVIERAKESMIGIPEETRKALDDGNTSYLRPLPGAARMYPETDVPTITITEEKLEFVRNNLPEMPEEKLVRFVKEYELNEDLAKQMVMSYHVDLFETLSKKYSKIKPTLIATTLEATIKEIKREGLDTDLLTEEHLEELFNGLSEDKMSKEAVPDVIKGFIENPTKKLDEILEIKGMSSMSVEEVESIIEDIINQNISQVNEKGMGAMGLLMGRCMAQLRGKADGKLINTTLQKKLKEKVQ
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit E, Glu-ADT subunit E.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatE subfamily.
Protein: MP8_TNVD
Sequence: MENTENVRSGRNQREYSKERQQEGGYKEVSKAAVRKEGDVKQDMGPSVSMTVVGEKVEFTQHFHF
What is the function of this protein?
Cell-to-cell movement.
What are the official names of this protein?
Probable movement protein p8.
What is the protein family that this protein belongs to?
Belongs to the carmovirus/necrovirus/panicovirus movement protein p8 family.
Protein: SYV_PARD8
Sequence: MEIASKYNPAEVEGKWYQYWLDNGFFKSKPDGREPYTIVIPPPNVTGVLHMGHMLNNTIQDILVRRARMMGKNACWVPGTDHASIATEAKVVNRLAGQGIKKTDLTRDEFLRHAWEWKEEHGGIILKQLRKLGASCDWDRTAFTMDEKRSESVIKVFVDLYKKGLIYRGVRMVNWDPKALTALSDEEVIYKEEHSKLYYLRYKIVGEEGYAVVATTRPETIMGDTAMCINPNDPKNQHLRGKKVIVPLVGREIPVIEDDYVDIEFGTGCLKVTPAHDVNDYMLGEKYNLPSIDIFNDNGTLSEAAGLYVGMDRFDVRKQIEEDLRNAGLLEKVEAYENKVGFSERTNVPIEPKLSMQWFLKMEHLAQIALEPVMKDDIKFYPPKFKNTYRHWMENIKDWCISRQLWWGHRIPAYFLPEGGYVVAETEEKALELAKEKCGNPNLTMSDLRQDEDVLDTWFSSWLWPISLFDGINNPDNEEINYYYPTSDLVTGPDIIFFWVARMIMAGYEYRGKMPFKSVYFTGIVRDKLGRKMSKSLGNSPDPLQLIEQYGADGVRMGLMLAAPAGNDIPFDDALCEQGRNFNNKIWNAFRLVKGWTVDDTIAQPEASAIAVKWFKMQLDKTIAEVDDSFSKYRLSEAMMAVYKLFWDEFSSWYLEMVKPGYQQPIDKATYEATLGFFDALLRLLHPFMPFITEELWQALEPRKEGESLMVAQMPEIAVIDSAYLDAFEIVKEIVGGVRTIRLQKNIPNKDALELQIVGEHNEAFNAVIAKMCNLSSISKVEEKAAGAVSFLVRTTEYAVPLGNLINVEEELAKLQEELKYQKGFLASVMKKLGNENFVSKAPAKVIEMEKKKQADAESKIKSIEESIAALTK
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_POLNS
Sequence: MSNGNIVQCIGPVVDIQFPRDKMPNIYDALTLVDGGEKSFSEKGLTFEVQQQIGDGVVRAIAMGASDGLRRGMEVKSTGKPISVPVGPATLGRIMDVLGRPIDDAGPIATEERRAIHQPAPKFDELSPSVDLLETGIKVIDLVCPFAKGGKVGLFGGAGVGKTVNMMELINNIAKQHSGLSVFAGVGERTREGNDFYHEMKESNVIDKVAMVFGQMNEPPGNRLRVALTGLTMAEAFRDEGRDILFFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGKLQERITSTKTGSVTSIQAVYVPADDLTDPSPATTFLHLDSTVVLSRDIAALGIYPAVDPLDSTSRQLDPQVVGQEHYEVARDVQMTLQRYKELRDIIAILGMDELSPEDKLAVSRARKIQRFLSQPFHVAEVFTGSPGKYVPLKETIRGFKMICSGELDHLPEQAFYMVGSIDEAIEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DDL_RHIWR
Sequence: MTHPLHIAVLMGGWSSEREVSLTSGNGVADALESLGHKVTRIDMDRDVALRLAEAKPDVVFNALHGTPGEDGTVQGMMDLMGLTYTHSGLTTSVIAIDKELTKQQLVPHGIRMPEGIIVESESLHAGDPMPRPYVLKPVNEGSSVGVAIIKERDNHGVPIHRDSHGPWQTFATLLAEPFIRGRELTVAVLGNRALGVTELVPSSGFYDYEAKYTDGLTTHICPADVPADIAEAAMRMALDAHRLLGCKGTSRSDFRWDDERGEAGLYLLEVNTQPGMTPLSLVPEQARHVGLTYADLVQAIVDEALAGKAAR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_PHOV8
Sequence: MKDLKELTRPNIWALKPYSSARDEYNGAEASVFLDANENPYNTPNNRYPDPMQRELKNMIAPIKKVDPDTIFLGNGSDEAIDLVYRAFCIPGVDNVVAIDPTYGMYQVCADVNDVEYRKVLLDENYQFSADKLLAATDDHTKLVFLCSPNNPTGNNLDRREMEKLLDTFQGLVIIDEAYSDFSDAPSFLADLDKYPNLIVFQTFSKAWGCAAIRLGMAFASKEIISIFSKIKYPYNVNLLTQKEAVMMLHRHYEVERWVKSLLEERTRLVNEFVELPCCEKIYPTDANFFLAKVTDAKKIYNYLVGKGIIVRNRTSISLCRDCLRVTIGTRPENDMLLEALKNYEC
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: RL23_AGRVS
Sequence: MTDLRHYDVIVSPSITEKSTLVSDFNQVVFNVARTASKPEIKAAVEALFGVKVTAVNTLLRKGKTKRFRGFAGKQKDVKKAIVTLAEGQSIDVSTGL
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: SNRK_MOUSE
Sequence: MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAGDNVLNGHRSKGLCDPAKKDELPELAGPALSTVPPASMKPAASGRKCLFRVEEDEEEDEEDKKPVSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFAYSWHRRDSSEGPPGSEGDGGGQSKPSSGGGVDKASPGEQGTGGGSQGGSGGTPSGTAGSSRRCAGPDSSSPSPASASAAPRGAELVQSLKLVSLCLGSQLHGAKYILDPQKALFSSVKVQEKSTWKMCISAPGPSPSADLDPVRTKKLRNNALQLPLCEKTISVNIQRSRKEGLLCASSPASCCHVI
What is the function of this protein?
May play a role in hematopoietic cell proliferation or differentiation.  Potential mediator of neuronal apoptosis (By similarity).
What are the official names of this protein?
SNF-related serine/threonine-protein kinase, SNF1-related kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SAS6_HUMAN
Sequence: MSQVLFHQLVPLQVKCKDCEERRVSIRMSIELQSVSNPVHRKDLVIRLTDDTDPFFLYNLVISEEDFQSLKFQQGLLVDFLAFPQKFIDLLQQCTQEHAKEIPRFLLQLVSPAAILDNSPAFLNVVETNPFKHLTHLSLKLLPGNDVEIKKFLAGCLKCSKEEKLSLMQSLDDATKQLDFTRKTLAEKKQELDKLRNEWASHTAALTNKHSQELTNEKEKALQAQVQYQQQHEQQKKDLEILHQQNIHQLQNRLSELEAANKDLTERKYKGDSTIRELKAKLSGVEEELQRTKQEVLSLRRENSTLDVECHEKEKHVNQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVVLEENGEKNQVQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVKKLEESKQLLKNNEKLITWLNKELNENQLVRKQDVLGPSTTPPAHSSSNTIRSGISPNLNVVDGRLTYPTCGIGYPVSSAFAFQNTFPHSISAKNTSHPGSGTKVQFNLQFTKPNASLGDVQSGATISMPCSTDKENGENVGLESKYLKKREDSIPLRGLSQNLFSNSDHQRDGTLGALHTSSKPTALPSASSAYFPGQLPNS
What is the function of this protein?
Central scaffolding component of the centrioles ensuring their 9-fold symmetry.  Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells.  Overexpression results in excess foci-bearing centriolar markers.  Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124).
What are the official names of this protein?
Spindle assembly abnormal protein 6 homolog, HsSAS-6.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis.
Protein: NRDR_MYCGI
Sequence: MHCPFCRHPDSRVVDSRETDEGQAIRRRRSCPECGRRFTTVETAVLAVVKRSGVTEPFSREKVIRGVRRACQGRQVDDDALNKLAQQVEDAVRATGSPEVPANEVGLAILGPLRDLDEVAYLRFASVYRSFSSAEDFEREIEALRAHREVSARS
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RS5_METS3
Sequence: MSFNIDEWEPKTKMGKLVKEGTITDIDEIFEKGLPIMELEIVDALVPDLEEEVMDVNLVQRMHKSGRKVNFRVIVAVGNKNGYVGLGQGKAKEVGPAIRKAVDNAKYNLIKVRRGCGDWGCVCGKEHTVPFKVQGKASSVSVSLMPAPAGVGLVVGDVGKTILNLAGIKDVWSQSFGQTQTTVNFANAIFDALKTLSAVKASEADLKKMGVKY
What is the function of this protein?
With S4 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: GLK_CAUVC
Sequence: MDGNHSGGLGLVGDIGGTNARFALVEFDGQDPRLIEPTAYRGEDYGTAEDAIEEYLRKVGVKHPDQAVVAVAGPIDHGQVHMTNLDWRISEDGLRRAGGFRNAKLINDFTAQALAAPRVGPKDLRQIGELPTSGEGDLAILGPGTGFGVAGLVRRHGQEIPLATEGGHVAFAPVDDVEIEVLRALTRRLDGGRVSVERILSGPGMEDLHVDLAAAEGRGVEALTAKQITERAVEGCADSLATVNRFCAILGSTAGDIALTLGARGGVFIAGGIAPRIIDILEKSPFRERFDSKGRLSGFTRSIPTHVILHPHTALIGAAVALTPEGRAAVS
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICE2_ASCSU
Sequence: RKPCGKNEVWTECTGCELKCGQDEKTPCALMCRPPSCECTPGRGMRRTHDGKCVPVSECPRKMPK
What is the function of this protein?
Defends the organism against the host's proteinases.
What are the official names of this protein?
Chymotrypsin/elastase isoinhibitors 2 to 5.
What is the protein family that this protein belongs to?
Belongs to the serine protease inhibitor-like (TIL domain-containing) family.
What are the subcellular locations of this protein?
Secreted.
Protein: TYSY_STAAW
Sequence: MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBR1_PIG
Sequence: MSSNTRVALVTGANKGIGFAIVRDLCRQFAGDVVLTARDVARGQAAVKQLQAEGLSPRFHQLDIIDLQSIRALCDFLRKEYGGLDVLVNNAAIAFQLDNPTPFHIQAELTMKTNFMGTRNVCTELLPLIKPQGRVVNVSSTEGVRALNECSPELQQKFKSETITEEELVGLMNKFVEDTKNGVHRKEGWSDSTYGVTKIGVSVLSRIYARKLREQRAGDKILLNACCPGWVRTDMGGPKAPKSPEVGAETPVYLALLPSDAEGPHGQFVTDKKVVEWGVPPESYPWVNA
What is the function of this protein?
NADPH-dependent reductase with broad substrate specificity.  Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics.  Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol.  Can convert prostaglandin E2 to prostaglandin F2-alpha (PubMed:1377683, PubMed:1597188).  Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates.  Catalyzes the reduction of S-nitrosoglutathione.  In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity).
What are the official names of this protein?
Carbonyl reductase [NADPH] 1, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], 20-beta-hydroxysteroid dehydrogenase, Alcohol dehydrogenase [NAD(P)+] CBR1, NADPH-dependent carbonyl reductase 1, Prostaglandin 9-ketoreductase, PG-9-KR, Prostaglandin-E(2) 9-reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TF2B_PYRHO
Sequence: MTKQKVCPVCGSTEFIYDPERGEIVCARCGYVIEENIIDMGPEWRAFDASQREKRSRTGAPESILLHDKGLSTDIGIDRSLTGLMREKMYRLRKWQSRLRVSDAAERNLAFALSELDRITAQLKLPKHVEEEAARLYREAVRKGLIRGRSIESVIAACVYAACRLLKVPRTLDEISDIARVEKKEIGRSYRFIARNLNLTPKKLFVKPTDYVNKFADELGLSEKVRRRAIEILEEAYRRGLTSGKSPAGLVAAALYIASLLEGEKRTQREVAEVARVTEVTVRNRYKELVEKLGIKVPIT
What is the function of this protein?
Stabilizes TBP binding to an archaeal box-A promoter.  Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
What are the official names of this protein?
Transcription initiation factor IIB, TFIIB.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
Protein: FMOD_MOUSE
Sequence: MQWASVLLLAGLCSLSQGQYDEDSHWWIQYLRNQQSTYYDPYDPYPYEPSEPYPYGVEEGPAYAYGAPPPPEPRDCPQECDCPPNFPTAMYCDNRNLKYLPFVPSRMKYVYFQNNQISAIQEGVFDNATGLLWVALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLHHNEIQEVGSSMRGLRSLILLDLSYNHLRRVPDGLPSALEQLYLEHNNVYTVPDSYFRGSPKLLYVRLSHNSLTNNGLATNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYLQGNRINEFSISSFCTVVDVMNFSKLQVLRLDGNEIKRSAMPVDAPLCLRLANLIEI
What is the function of this protein?
Affects the rate of fibrils formation.  May have a primary role in collagen fibrillogenesis.
What are the official names of this protein?
Fibromodulin, FM, Collagen-binding 59 kDa protein, Keratan sulfate proteoglycan fibromodulin, KSPG fibromodulin.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: CH10_FRATN
Sequence: MNIRPLQDRVLVRRAEEEKKSAGGIILTGSAQEKPSQGEVVAVGNGKKLDNGTTLPMDVKVGDKVLFGKYSGSEVKVGDETLLMMREEDIMGIIA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUA8_PONAB
Sequence: MPGIVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKMGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLKPAIHGSRFYFWTK
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8, Complex I-19kD, CI-19kD, NADH-ubiquinone oxidoreductase 19 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA8 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Mitochondrion.
Protein: RSMA_THESQ
Sequence: MKTSDYLKKYGVRLKKHLGQVFLSDDRIAKRIVKAADLTPEDVVVEIGAGAGTLTEELTKTGARVIAYEIDESLAPILQERLSKYPNVELRFEDFLKAKDVPEGAICVSNIPYNITGPLMEKIIEWKFKRAIVMVQKEVGERILAKPGKKTYGYLSVVVQTFYEVKKLFDVSRSCFVPNPEVDSTVVDLKRKPVDLDFEKFKKFVSMIFAKKRKTLKNNLKPFLSIFEGVDLSRRAEQLTVEEIVELYEKWRRALECSRG
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPD1_YEAST
Sequence: MSAAADRLNLTSGHLNAGRKRSSSSVSLKAAEKPFKVTVIGSGNWGTTIAKVVAENCKGYPEVFAPIVQMWVFEEEINGEKLTEIINTRHQNVKYLPGITLPDNLVANPDLIDSVKDVDIIVFNIPHQFLPRICSQLKGHVDSHVRAISCLKGFEVGAKGVQLLSSYITEELGIQCGALSGANIATEVAQEHWSETTVAYHIPKDFRGEGKDVDHKVLKALFHRPYFHVSVIEDVAGISICGALKNVVALGCGFVEGLGWGNNASAAIQRVGLGEIIRFGQMFFPESREETYYQESAGVADLITTCAGGRNVKVARLMATSGKDAWECEKELLNGQSAQGLITCKEVHEWLETCGSVEDFPLFEAVYQIVYNNYPMKNLPDMIEELDLHED
What is the function of this protein?
Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions.  Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells.
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome.
Protein: NTH_CAEEL
Sequence: MHSFSMKRVVASSSVAAVATCDVEGTVVAWRRDVELIRKMRKDMIAPVDTMGCHKLADPLAAPPVHRFQVLVALMLSSQTRDEVNAAAMKRLKDHGLSIGKILEFKVPDLETILCPVGFYKRKAVYLQKTAKILKDDFSGDIPDSLDGLCALPGVGPKMANLVMQIAWGECVGIAVDTHVHRISNRLGWIKTSTPEKTQKALEILLPKSEWQPINHLLVGFGQMQCQPVRPKCGTCLCRFTCPSSTAKNVKSETEETSTSIEVKQEVEDEFEDEKPAKKIKKTRKTRTKIEVKTESET
What is the function of this protein?
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage.  The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site.  The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination.  Primarily recognizes and repairs oxidative base damage of pyrimidines.
What are the official names of this protein?
Endonuclease III homolog, CeNTH, Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase, DNA glycosylase/AP lyase.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.