PharMolix/UniProtQA huggingface dataset:
Protein: GLYA_CUTAK
Sequence: MSDPRAVDPTARDIAEKLAPAYRTMLDAIAQVEPRIAEATRAELTDQRHSLKLIASENYASLPVLATMGTWFSDKYAEGTAGHRFYAGCQNVDTVETIAAEHACALFGAEHAYVQPHSGIDANLTAYWTILAHHIETPALSEFGARTVNDLTQVDWDTLRHRFNDQRAIGMSLDAGGHLTHGFRPNISGKMFDQRSYGTDPQTGLLDYDKVAELAREFKPLVIVAGYSAYPRRVNFAKMREIADEVGAVLMVDMAHFAGLVAGKVFTGDENPIPHAQVVTTTTHKSLRGPRGGMVLTTKDYADDVDRGCPMVLGGPLSHVMAAKAVALAEARTQTFRDYAQRVANNAKALAEGLMKRGVKLVTDGTDNHINLLDVTTSFGLTGRQAEAALLDAGVVTNRNSIPTDPNGAWYTSGIRIGTPALTSRGFGPDEFDQVAELIVTTLEATTPMTASTGKPGKAKYQIADGVAQKVHDAADELLGNFPLYPGLDLA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLII_AQUAE
Sequence: MKGIRRNLQKSYLKRCSEMYLRGLKVSGEIVSAKGIYLEAILPFANIGNEVEIQSNSRRIRGEVIGFSGDKVLVMPYEPVFGLRKGDKVLLKNELVSTKTGNGVVGKVVDPFGNPLDGGFIGFVEEKGLELPQINPLYRERIREVFDTGVRSVNALFTLGKGQKIGIFAGAGVGKSTLLGMITRHSKADVVVLALIGERGREVKEFLEEVLGEEGLKKSVVVVSTADQSPILKVKGAISAVVHAHHFASQGKDVLLLMDSITRLALAQREIGLAAGEPPTLKGFTPSVFQLLTRIAESCGAFKKGSITGIFTVLVEGDDISLDPIADSLMGVLDGHIILSRKRAVRGLFPAVDPVRSLSRLMPKLVSEEHFMKANFFKEVLSKFEDVEELVRIGLYKGGSNPLVDKVINNLEKVESFFKQKPEEKVNFEESLKALDEIYSLLK
What is the function of this protein?
Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.
What are the official names of this protein?
Flagellum-specific ATP synthase.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CODY_STAAM
Sequence: MSLLSKTRELNTLLQKHKGIAVDFKDVAQTISSVTVTNVFIVSRRGKILGSSLNELLKSQRIIQMLEERHIPSEYTERLMEVKQTESNIDIDNVLTVFPPENRELFIDSRTTIFPILGGGERLGTLVLGRVHDDFNENDLVLGEYAATVIGMEILREKHSEVEKEARDKAAITMAINSLSYSEKEAIEHIFEELGGTEGLLIASKVADRVGITRSVIVNALRKLESAGVIESRSLGMKGTFIKVKKEKFLDELEKSK
What is the function of this protein?
DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability.  During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM2R_SOLLC
Sequence: MAEILLTSVINKSVEIAGNLLIQEGKRLYWLKEDIDWLQREMRHIRSYVDNAKAKEAGGDSRVKNLLKDIQELAGDVEDLLDDFLPKIQQSNKFNYCLKRSSFADEFAMEIEKIKRRVVDIDRIRKTYNIIDTDNNNDDCVLLDRRRLFLHADETEIIGLDDDFNMLQAKLLNQDLHYGVVSIVGMPGLGKTTLAKKLYRLIRDQFECSGLVYVSQQPRASEILLDIAKQIGLTEQKMKENLEDNLRSLLKIKRYVFLLDDIWDVEIWDDLKLVLPECDSKVGSRIIITSRNSNVGRYIGGESSLHALQPLESEKSFELFTKKIFNFDDNNSWANASPDLVNIGRNIVGRCGGIPLAIVVTAGMLRARERTEHAWNRVLESMGHKVQDGCAKVLALSYNDLPIASRPCFLYFGLYPEDHEIRAFDLINMWIAEKFIVVNSGNRREAEDLAEDVLNDLVSRNLIQLAKRTYNGRISSCRIHDLLHSLCVDLAKESNFFHTAHDAFGDPGNVARLRRITFYSDNVMIEFFRSNPKLEKLRVLFCFAKDPSIFSHMAYFDFKLLHTLVVVMSQSFQAYVTIPSKFGNMTCLRYLRLEGNICGKLPNSIVKLTRLETIDIDRRSLIQPPSGVWESKHLRHLCYRDYGQACNSCFSISSFYPNIYSLHPNNLQTLMWIPDKFFEPRLLHRLINLRKLGILGVSNSTVKMLSIFSPVLKALEVLKLSFSSDPSEQIKLSSYPHIAKLHLNVNRTMALNSQSFPPNLIKLTLANFTVDRYILAVLKTFPKLRKLKMFICKYNEEKMDLSGEANGYSFPQLEVLHIHSPNGLSEVTCTDDVSMPKLKKLLLTGFHCRISLSERLKKLSK
What is the function of this protein?
Inhibitor of viral mouvements which confers resistance to some tobamoviruses including tomato mosaic virus (ToMV) (e. g.  isolates L, W3 and SL-1) and tobacco mosaic virus (TMV), but not to resistance-breaking isolates (e. g.  B7, LT1, LII, Ltbl, ToMV2, and ToMV1-2) ToMV and tomato brown rugose fruit virus (ToBRFV) (PubMed:17238011, PubMed:2535549, PubMed:1730937, PubMed:15290376, PubMed:16172136, PubMed:21310506, PubMed:29582165, PubMed:28107419).  Elicits a hypersensitive reaction in response to avirulent (Avr) movement proteins from resistance inducing tobamoviruses (e. g.  ToMV and TMV) strains, thus leading to programmed cell death (PubMed:15290376, PubMed:21310506).
What are the official names of this protein?
ToMV resistance protein Tm-2(GCR236), Disease resistance protein Tm-2.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TAF12_ARATH
Sequence: MDQPRQSSTASQPPETPPQPSDSKPSTLTQIQPTPSTNPSPSSVVSSIPSSPAPQSPSLNPNPNPPQYTRPVTSPATQQQQHLSQPLVRPPPQAYSRPWQQHSSYTHFSSASSPLLSSSSAPASSSSSLPISGQQRGGMAIGVPASPIPSPSPTPSQHSPSAFPGSFGQQYGGLGRGTVGMSEATSNTSSPQVRMMQGTQGIGMMGTLGSGSQIRPSGMTQHQQRPTQSSLRPASSTSTQSPVAQNFQGHSLMRPSPISSPNVQSTGASQQSLQAINQPWLSSTPQGKPPLPPPSYRPQVNSPSMQQRPHIPQQHISTSAATPQPQQQQSQQQHQPQEQLQQLRSPQQPLAHPHQPTRVQGLVNQKVTSPVMPSQPPVAQPGNHAKTVSAETEPSDDRILGKRSIHELLQQIDPSEKLDPEVEDILSDIAEDFVESITTFGCSLAKHRKSDILEAKDILLHVERNWNIRPPGFSSDEFKTFRKPLTTDIHKERLAAIKKSVTATEAANARNQFGHGTANARGGQAKTPSNPMGSTTFNH
What is the function of this protein?
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 12, TBP-associated factor 12, AtTAF12.
What is the protein family that this protein belongs to?
Belongs to the TAF12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GATC_SYNSC
Sequence: MSQISSDDVRKVAQLARLDLPEDKIATYTGQLESILEYVGQLQQVDTEGVPETTRAVEVTNVTRVDGVQPTAVREDILDQAPQREGDFFRVPKILAD
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: Y880_BACCR
Sequence: MTKNIHDVAYELQKAIAENEDFKTLKESYAAVQADTASKNLFDEFRTMQLSLQQKMMQGQEITEEDNQQAQEVVARIQQDAKITKLMETEQRLNVVIGDVNKIIMKPLEELYSAQQQA
What are the official names of this protein?
UPF0342 protein BC_0880.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: SPDE4_HUMAN
Sequence: MASGQARPPFEEESPQPSTTVRSPEVVVDDEVPGPSAPWIDPSPQPQSLGLKRKSEWSDESEEELEEELELERAPEPEDTWVVETLCGLKMKLKRKRASSVLPEHHEAFNRLLGDPVVQKFLAWDKDLRVSDKYLLAMVIAYFSRAGLFSWQYQRIHFFLALYLASDMEEDNQAPKQDIFSFLYGKNYSQRPLFHKLRYQLLCSMRWRTWVSPEEMEEIQAYDPEHWVWARDRTLIS
What are the official names of this protein?
Speedy protein E4.
What is the protein family that this protein belongs to?
Belongs to the Speedy/Ringo family.
Protein: ISPF_FRACC
Sequence: MNTVILPRVGVGVDVHPFAAGRPCWVACLEWPGETGLAGHSDGDVAAHAACDALLTASCLGDLGRVFGTDRPEYAGASGAVLLAETARLLGAAGWAIGNVSVQVIGNRPRMAGRREDAQKAMSVALGASVSLSATTTDGLGLTGRGEGLAAIATALVIRA
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: AP1G1_YEAST
Sequence: MGSSLRSFIKDVRGAKTLADERAIITKQSAKIRTKLRDDHLPHEKRRVNIQKLLYLYILGEKTHFGQVESINLIASDDFVDKRLGYLAATLLLDESEDLLTLLTNMLNNDLHHPNKYAVSLALTSLGFLSSPELARDLYPDVENIIKNSRDPFLLKKALQCAAKLIFKDVSLLEIFNIEDITKILSSHSICTHGVLLGVTKIIQSILLIGLNRKKDEDEDEDGIDYSNDILSPLSLLLRDFFIRLENMNSKNIEPGYDVQGICDPFLQCEIIYTLKLYFQVGELLNSNNVLDYKDNFCDLLTRIATNTDSTKNSGQAILYETVKTIFSLDLNQPLRVLGINILAKFLAGKDNNTKYVSLNTLLKVVPQEPTAVQRHRKFISHCLQDTDVSIRMRALELSFAILDDSNLVELVNELMKFLAKQDEDSKDLIIYTIDHLIDTFDTRVVKDESWKLDVFFNILKLVGSFINYEKINDILIIINNTSQLSDKSEFLRKMLTISLNGTSAEISEENIGWQLVLIWCIGEYGDLVLNEGNKNGADIINESSITDYLLTLQELYTATNLKIINYILTAALKLSVRFHDAKNIEKLRQLILSYTDSTDLSLQMKSNQYEIFFNQSISVKKIILETMPKFEKITEEQDNGKALSKNLISNEPVDLLSDLLGEDSKAESKASTGDNVKPIDILEEIFGEKNDIAQVPKNANKEESINHSSAVEANSGVTLPLDANKIYDSSSLNVYASLLSANSGLAHLDLYFQAKSLISDLKTFCAVPKAQKLTLGQLYPSSTINASQICKQSLKISGSGKLKLRVKLDFHLNGSSSITNEQFDHKFDETL
What is the function of this protein?
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles (PubMed:10564262).  Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (PubMed:10564262).  The AP-1 complex interacts directly with clathrin (PubMed:10564262).  Component of the AP-1-related (AP-1R) complex, an adapter protein complex that mediates sorting of cargo SNARE SNC1 (PubMed:26658609).  In contrast to the APM1-containing AP-1 complex, AP-1R is incapable of sorting CHS3 (PubMed:26658609).
What are the official names of this protein?
AP-1 complex subunit gamma-1, Clathrin assembly protein complex 1 gamma large chain, Clathrin assembly protein large gamma chain, Gamma-adaptin.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: SSUB_BURTA
Sequence: MTGTSLAATYGPIAGADLEAELAQPRTADGDAQDAAVLERDGGAHALPFASGGAFGRAPRDDDDDRRGAGDASVRLTRVSKRYGERTVLADVDLAIERGGFVSIVGRSGCGKSTLLRLVAELETPSAGTLVKRGDGGGVLDTRIMYQDARLLPWKTVLQNVMLGLGRRAKDDARAVLDEVGLLARAHDWPAQLSGGQRQRVALARALVHRPQLLLLDEPLGALDALTRIEMHELIERLWREHRFTALLVTHDVQEAVSLADRILLIEAGRIAFDQPVPLERPRARASAAFAELEDRVLQRVLTGSDPAGATSAAASAGGAARGRAAQANGLRWAV
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SAPB_BACSU
Sequence: MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVIAVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGLTTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIRMSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDIKAIEGVVGVKCDTL
What are the official names of this protein?
Protein SapB.
What is the protein family that this protein belongs to?
Belongs to the MgtC/SapB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: F216B_BOVIN
Sequence: MGEKWKRQQKLCNVPHIPRIRVPRSASDTPLLKDLTQGQQRYFYSIMRIYSPRPQWEALQARYLHSLQHQQLLGYITQREASACAAVLRDSTKRASAKAGPHRTVPQRAAGRTRTQPSARPVCVIPLRARSTRLPSLRSRAVHKL
What are the official names of this protein?
Protein FAM216B.
What is the protein family that this protein belongs to?
Belongs to the FAM216 family.
Protein: NUOB_ECO27
Sequence: MDYTLTRIDPNGENDRYPLQKQEIVTDPLEQEVNKNVFMGKLNDMVNWGRKNSIWPYNFGLSCCYVEMVTSFTAVHDVARFGAEVLRASPRQADLMVVAGTCFTKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFIPVDVYIPGCPPRPEAYMQALMLLQESIGKERRPLSWVVGDQGVYRANMQSERERKRGERIAVTNLRTPDEI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y413_OCEIH
Sequence: MDVRFPIGKLQVPEKVTIEDIHEWLKQIETYTNRLGETVNSLNDEELSKTYREGSWDIRQLVHHIADSQLNMYQRLKLALTDESPTVPAFDQEKWAIQPDTNLPVETSIKMLEGINERIVSLGYRLTEEQLDQSFVHQINGEISVASKVAKLAWHEEHHLAHIKIALSNNSGS
What is the function of this protein?
Possible metal-dependent hydrolase.
What are the official names of this protein?
Putative metal-dependent hydrolase OB0413.
What is the protein family that this protein belongs to?
Belongs to the metal hydrolase YfiT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCP10_SCHPO
Sequence: MSGSRKQEAIDELRNSLDVPADTAQSVLESFNWDVQEAIESLTGESSRVDRNSKLGLSFGVFQSVFSLLFSGLHKLWMILSRVPLISTFIPIFGTTKRVLSPADTANKLVQNLEEQYGTEHIDFFTDGGYMEALTRIKRNYGVALLFFTSSKNDDSETFSRSVLMNQELKEFLNRRNILCWTGDVCEDEAFRGSRQFHCTKFPSAVLVMYSPQLSELVVAAQLHGCLDSSSIITNLTNALAKHLPSLERFRSEREAREAARELRRQQDNAYQASLARDRERQAFARAEEERLAKEKEEREIVQKKKKQYRAWLASNLPPEPSSEDEPARLSIRFPDGSRAVRRFKKDDTVESVYNYVDYMLFEKEEPEEFGRATSSSNPVTPPSDYKHDFHFQLYSSLPRALLKPSVAISTNKAIFPNGTVVVELDD
What is the function of this protein?
Involved in protein degradation through the ubiquitin/proteasome pathway.
What are the official names of this protein?
UBX domain-containing protein 10.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: FOLD_PROM1
Sequence: MPKILDGKKLAQEIELILQQAIESGLEVAKRRPGLAVLRVGDDPASGVYVNYKEKACDRIGVRSFAKHLKEDISLEELTETIKSLNEEKNVDGILLQLPLPSHLDEAALLRSIDPDKDADGLHPLNLGRLIKGEKGPRSCTPAGVMSLLERNQIKIEGKRAVVVGRSILVGKPMALMLEAANATVTIAHSRTKDLPSLTKEADLLVVAAGKPYLIGKNHVSENCVVIDVGIHRLPPDEENIKELKKTKLCGDVKIFEIEDKVAAYSPVPGGVGPMTVTMLLANTVDRWQKHCGLPLTISHLLP
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: GCH1_XYLFT
Sequence: MDHSKQQNASITQAQAEEAVRTLLRWAGEDPTREGLLDTPRRVVEAYGDWFSGYREDPHDYLQRTFEEISCYDEMIVLRNITYESHCEHHMAPIIGKVHVGYLPNGKVVGISKLARVVESYARRFQIQEKMTAQIAACIQDTLTPRGVGVVIEGAHACMTTRGIHKRGVSMVTSKMLGTFREDARTRAEFLQFIEVGTNVIDL
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: RPOY_BACVZ
Sequence: MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKDQKYNIEFVQPVDGAFLEYEKQSENFKVLEL
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: RS10_XANOR
Sequence: MSEKQKIRIRLKAFDHRLIDRWASEIVETAKRTGAQVRGPIPLPTKIERYTILVSPHADKDARDQYETRTHKRVLDIVDPNDKTVDALMKLELAAGVDVQIKLT
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RPO1N_SACS2
Sequence: MSEKNIKGIKFGILSPDEIRKMSVTAIITPDVYDEDGTPIEGSVMDPRLGVIEPGQKCPTCGNTLGNCPGHFGHIELVRPVIHVGLVKHIYEFLKATCRRCGRVKISEDEIEKYSRIYNAIKKRWPSAARRLTEYVKKTAMKAQVCPHCNEKQYKIKLEKPYNFYEERKEGVAKLTPSDIRERLEKIPDSDVEILGYDPTTSRPEWMILTVLPVPPITIRPSIMIESGIRAEDDLTHKLVDIVRINERLKESIDAGAPQLIIEDLWDLLQYHVATYFDNEIPGLPPSKHRSGRPLRTLAQRLKGKEGRFRGNLSGKRVDFSSRTVISPDPNISIDEVGVPEIIAKTLTVPERITPWNIEKLRQFVINGPDKWPGANYVIRPDGRRIDLRYVKDRKELASTLAPGYIIERHLIDGDIVLFNRQPSLHRISMMAHRVRVLKGLTFRLNLLVCPPYNADFDGDEMNLHVPQSEEAIAEAKEIMLVHKNIITPRYGGPIIGAAQDYISGAYLLTVKTTLLTKEEAQQILGVADVKIDLGEPAILAPREYYTGKQVISAFLPKDFNFHGQANVSSGPRLCKNEDCPHDSYVVIKNGILLEGVFDKKAIGNQQPESILHWLIKEYSDEYGKWLMDNLFRVFIRFVELQGFTMRLEDVSLGDDVKKEIYNEIDRAKVEVDNLIQKYKNGELEPIPGRTLEESLENYILDTLDKLRSTAGDIASKYLDPFNFAYVMARTGARGSVLNITQMAAMLGQQSVRGERIKRGYMTRTLPHFKPYDISPEARGFIYSSFRTGLKPTELFFHAAGGREGLVDTAVRTSQSGYMQRRLINALSDLRAEYDGTVRSLYGEVVQVAYGDDGVFPMYSAHGKTVDVNRIFERVVGWKA
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms the clamp head domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1N, DNA-directed RNA polymerase subunit A'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRC8D_MOUSE
Sequence: MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTPPGNADITTEVPRMETATHQDQNGQTTTNDVAFGTSAVTPDIPLQATHPHAESTLPNQEAKKEKRDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHVSRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLESLPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDQLFDTLPLEVKEALNQDVNVPFANGI
What is the function of this protein?
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29773801).  The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity).  Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity).  Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29773801).  VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity).
What are the official names of this protein?
Volume-regulated anion channel subunit LRRC8D, Leucine-rich repeat-containing protein 5, Leucine-rich repeat-containing protein 8D.
What is the protein family that this protein belongs to?
Belongs to the LRRC8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:29773801). Requires LRRC8A for expression at the cell membrane (By similarity).
Protein: NTPPA_DESPS
Sequence: MYKCDKPLILASSSPRRKAFLDQLGLEYSVRVKSIDEFAQPEESPEAFVCRMALEKGSAVSYQHPDSWVIAADTIVCLDQKILGKPRDSEDAVAMLCRLAGRSHTVMTAFAIICEKEKISEVQLVETSVYFSSFGEVEARAYVATGEPLDKAGSYGIQGVGALFVRKIAGSYSNVVGLPLAELVERLLYYSVISI
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_CUPTR
Sequence: MKASQFFISTLKEAPADAEIVSHKLMMRAGMIKKLGAGIYNYMPIGLRVIRKVENIVREEMNRAGAVELSMPVIQPAELWQETGRWDKMGPELLRLKDRHERDFAVQPTSEEVVTDIARSEIRSYKQLPVNFYQIQTKFRDERRPRFGIMRGREFTMKDAYSFDRDTDGLRKSYENMYDAYVRIFRRFGLEFRAVAADNGAIGGSGSHEFHVIAETGEDAIVYCPTSAYAANMEAAEALPLVAERAAPTQDLVKTFTPEKVKCEQVAEFLNIPLETNVKSIVLATDSDAGPQIWLLLIRADHELNEVKASKVPGLAEFRFATENEIVEAFGSPPGYLGPIDMKKPVKVVADRTVANMSDFVCGANYRDYHYTGVNWGRDLPEPIVADLRNVVAGDASPDGQGTLEICRGIEVGHVFMLGTRYSESMNATFLDENGKTQPMQMGCYGIGITRILGAAIEQNFDERGIIWPAAIAPFAVVICPVGYDRSEAVKAEADRIHAELLAAGVDVILDDRGERPGVMFADWELIGVPHRVVVGDRGLKEGKVEYQGRRDAQATAVSVAEVVGHVRSLLAN
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIGY_XENTR
Sequence: MFFSLPVLTVLIPLVSLTGLLYSASVEEDFPNGCTSTASLCFYSLLLPITLPVYVFFHLWTWMGLKLFRHN
What is the function of this protein?
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.  May act by regulating the catalytic subunit PIGA.
What are the official names of this protein?
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y, Phosphatidylinositol-glycan biosynthesis class Y protein, PIG-Y.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.