PharMolix/UniProtQA huggingface dataset:
Protein: PYRB_FRAAA
Sequence: MVGVGGERRSGMKGHLLSTEDLSRDDALLVLDTAERMARVAEASVRKLPTLRGRTVVNLFFEDSTRTRTSFEVAAKRLSADVINFSARGSSVSKGESLKDTAQTLEAMGADAVVCRHSASGAPHRLATWVRGSVVNAGDGTHEHPTQALLDAFTMRQRLGRVDGLAVTIVGDVLHSRVARSNVWLLATLGASVTVVAPPTLLPIGVSSWPVEVSYDLDAVLPKTDVVMMLRVQRERMSAAFFPTEREYSRRYGLDVDRAATLPEHALVMHPGPMVRGMEIASRVADSDRSTVVEQVANGVSVRMAVLYLLLGGSGEVS
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: MOES_HUMAN
Sequence: MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM
What is the function of this protein?
Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex.  Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266).  Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266).  These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356).  The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160).  Modulates phagolysosomal biogenesis in macrophages (By similarity).  Participates also in immunologic synapse formation (PubMed:27405666).
What are the official names of this protein?
Moesin, Membrane-organizing extension spike protein.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, microvillus. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). Localizes at the uropods of T lymphoblasts.
Protein: NAGZ_ALKEH
Sequence: MLLGPLMMGLEGTRLSSEERTLLCHPRVGGVILFSRNFQSPEQLRALTDAIHALRRPPLLIAVDQEGGRVQRFREGFTRLPAPGVLAAVYDRDPAQARALSHDMGWLMASELLACGVDFSFAPVLDLGRGVSRVIGDRAFHSRPEAVVHLARGWVAGMRDAGMAAVGKHFPGHGSVAPDSHLELPRDPRARSALEGADLVPFRRLAGDRLPGMMTAHVIYQAIDPLPATFSGYWIGEVLRGELGYEGAVFSDDLGMAAAAEAGPLPRRARAAMEAGCDMVLLCNHPEAVPAVLRHLPDPDPVSDMRLVRLHGRPVVDNWRKLHRLTRWQEAVRRVRGQDPSPEGELEV
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_PROMH
Sequence: MKKTVVVFSGGQDSTTCLIQALEQYDEVHCITFNYGQRHKEEIEVAQRVSQLLGATAHKVLDVSLLNELAISSLTRDNIPVPDFKQSEQSDIPSTFVPGRNILFLTLAAIYAYQIGAESVITGVCETDFSGYPDCRDEFVKALNHAVNLGIARDIQFITPLMWLDKAQTWALADYYGKLDFVRHNTLTCYNGIQGDGCGQCAACHLRERGLHGYLQDKNAVMDAMKNKVGLK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: AMPA_VARPS
Sequence: MDFQLKTLTVARAAAEKSDVLIVLVGSAPLTAKDPLSALIASARKAGDLPDKAGKLLALYHPDEVVASRVVLAAIGDGKPASVRSGVIAAVNAAKAYGPKRVVMAFAQEADGAAVGSAVAAAADASYVYTTTKAKTSNGENGRTIRHLTLGVADAAAVGTAFDEARATVAGIELAKEWGNRPGNYCTPTLLAEAAKELGKLPRVKCEVLGPKEVQKLGMGSFAAVAQGSAEPLRFIVLRYQGGPKDQAPVVLVGKGITFDTGGVSLKPAAEMDEMKFDMCGAASVLGTFRALGEIQPAINVVGLVPSCENMNDGRAIKPGDVVTSMSGQTIEVLNTDAEGRLILCDALTYAKRFEPAAVIDIATLTGACVVALGGVRSGLFTSDDSLAEALQAAGEQSQDRCWRLPLDDEYAEGLKSNFADVANVAGRAGGAITAAKFLQRFAGDFTWAHLDIAGTAWKSGAAKGSTGRPVGLLVSYLMERARSGAAQAVSPKKAARKEPGAAARKARSAQ
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FDR_SPHSX
Sequence: MTDTHYDVVIVGAGHGGAQTAIALRQNGFAGTIAIIGAEPDLPYERPPLSKEYLAAEKGFERILIRPASFWNDRHIAMHLGCAVERVDPTQRLVFLADGRSMGYGDLVWCAGGSARRLDCTGHDLGGVHYVRTRADTDALAAELPGVSKVVIIGGGYIGLEAAAVMAKFGKNVTLIEALDRVLARVAGEPLSRFFEEKHRSRGVDVRLRTKVGCLLGQDGRVTHVELNDADPIPADLVIVGIGIIPAISPLVVAGAKASNGLLVDASGRTSIPHVYALGDCAAHVNSFAPNDIPIRLESVQNANDQAVVVARTICGTAAQYHAVPWFWSSQYDIRLQTVGLTAGYDQTFVRGDPATGSFTVVYGRDGRVIALDCVNATKDYVQGKRLVEAKALIEPGMTDPQYPLKNFMTPSPA
What is the function of this protein?
Part of the multicomponent carbazole 1,9a-dioxygenase (CARDO), that converts carbazole (CAR) into 2-aminobiphenyl-2,3-diol.
What are the official names of this protein?
Ferredoxin--NAD(P)(+) reductase fdr, Carbazole 1,9a-dioxygenase, ferredoxin reductase component, CARDO.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
Protein: UPP_CLOD6
Sequence: MSKVVETNHPLIQHKLTLMRDKNTGSKDFRELLTEIAMLMGYEITKDIPLKDVEIETPIQKTSSKVVAGKKLAIIPILRAGLGMVDGLVSLMPAAKVGHVGLYRDPETLKPVEYYCKLPQDIGERDIIVVDPMLATGGSAVAAIDLLKSKGAKSIKLANLVAAPEGIAEVQKYHDDVDIYVASVDERLNEHGYIIPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: NFIP1_RAT
Sequence: MALALAALAAVEPACGTGYQQLQNEEEPGEREQTAGDAPPPYSSISAESAAYFDYKDESGFPKPPSYNVATTLPSYDEAERTKAEATIPLVPGRDEDFVGRDDFDDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYFDGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPETFSNLPRTRVLFIY
What is the function of this protein?
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets.  As a result, controls many cellular processes.  Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation.  Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion.  Restricts the production of pro-inflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination degradation of RORC.  Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination.  Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells.  Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS.  Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation.  In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity.  Important for normal development of dendrites and dendritic spines in cortex.  Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1.  Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH.  Modulates EGFR signaling through multiple pathways.  In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation.  As a result, may control cell growth rate.  Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity.
What are the official names of this protein?
NEDD4 family-interacting protein 1.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Synapse, synaptosome. Cell projection, dendrite. Secreted. Note=Detected in exosomes and secreted via the exosomal pathway.
Protein: PSBF_IPOSE
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVFFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SAHH_NOCFA
Sequence: MTTSELPARTSPTPDVRNGIDYKVADLTLAEFGRKEIRLAEHEMPGLMALRREYADVQPLKGARISGSLHMTVQTAVLIETLTALGAQVRWASCNIFSTQDHAAAAVVVGPHGTVEEPKGVSVFAWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDATMLVLRGAQFEKAGVVPPEDADHSAEYKVFLNLLRERFETDRGKWTAIAESVRGVTEETTTGVLRLYQFAAAGELVFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPINALQALMDGYDVVTVEQAIGEADIVITATGNKDIITLDHMKAMKDQAILGNIGHFDNEIDMAALERSGATRLTIKPQVDLWTFGESGKSIIVLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKPEEYDNEVYRLPKHLDEKVARIHVEALGGTLTKLTKDQAEYIGVDVEGPYKPEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOH_YERPE
Sequence: MKQLYWYTCGEGDCDLVLLHGWGLNSGVWHCIIDRLAPHFRLHLVDLPGYGRSQDYGAMSLADMAERVAQQAPKQALWLGWSMGGLVASQIALSQPECVRGLITVSSSPCFTARDEWPGIKPEVLAGFQHQLSDDFHRTVERFLALQTLGTESSRQDARLLKSVVLQHQMPDVEVLTGGLAILRTADLRTALAGFTLPFMRVYGHLDSLVPRKVASLLDSAWPQTQSVVMQGAAHAPFISHPNDFAKLILNFAEENKK
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_VIBCH
Sequence: MLMSTTPYFGEVSKRRTFAIISHPDAGKTTITEKVLLFGRAIQVAGTVKGRGSNQHAKSDWMEMEKERGISVTTSVMQFPYGDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEDRTRKLMEVTRLRDTPIVTFMNKLDREIRDPMELMDEVENELKIACSPITWPIGCGKEFKGVYHIHRDETILYTSGQGHTIQEERIIKGLDNPELDQAVGADLAAQLREELELVLGASHEFDRELFLQGELTPVFFGTALGNFGVDHMLDGLTQWAPSPMPRQAAERVVEASEEKFTGFVFKIQANMDPKHRDRIAFVRIVSGTYKQGMKMNHVRLGKQVNISDAVTFMAGDRARAEEAFAGDIIGLHNHGTIQIGDTFTQGETLKFTGIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLQNNDLIVGAVGVLQFDVVVSRLKSEYNVEAIYEGVNVATARWVECDDVKKFEEFKRKNQSNLALDGGDNLAYIAPTMVNLNLAQERSPEVKFRATREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORFV2_GOCV
Sequence: MFCVCLTLKIVYFDLIRPMCSLRRLYRRLRLVARLRREYRLRGLARYSGMMGSGFLWAGTKPLQAPYILLPAPVLRTPHPTRKLQTPLNEPPRTWRKTATTHTRGGSSLLITLPLKITVP
What are the official names of this protein?
Uncharacterized protein ORFV2.
Protein: IF4G_WHEAT
Sequence: MMHQGQTMMYPSVAHPIPPQLGNVNLNMASQYPQQQQNKLVAPRKSSNIKITDPNTNKEVVLGRPSPNVAAQPQQVSGVATQPMVYYTNPQQTSYNQSGTYYSGTAGVVPTGSQGRFGYPATQAGQSIPFMNPSMSNTVPASHKDNIAGPAPSGQSQLIGKPQGGLHMEKPVPSVKISMPAGRSDASKFRVADHAVQHRQKDNEVISGAMVSNKPVSEKESKAPSIPEKHSKESKAPSAVEKHPTAVTQPLPIQAAKPETDAATANSPSFLTGADEKKESLPMTDSLKDNKKNATRNDTKNLPQQPQSASPAEELKGQTSVKLGDDVVGHMETKSFDSEKVDLTSKVSGLTSATSESSISPILGKSEADSTSVNAADVPAMVISSAKLSSASTGEPQAVESLGVAAVKSKEIEITHQISPESSDGKIMSDSTENESHDFTVDLAEQASLATSKPGNSDATSFVTDPQELPKECTTSVPEDHSLMNTSHNKDTQTLSASVDASDVSEVNSGTSSESTSQSTNDKDIRSSIQETGLAVSGITPGMLPVNHSVASEGQVKHADGAKDESSTEQSSAVPTGSVRPLSREKPTAELARTKSTAGRKKKRKEMLSKADAAGSSDLYNAYKGPQEQSESVATSDGADSSSTVDGTHVLPEESEREVMCEDDGKKKVEPDDWEDAADMSTPKLQSSDSGNQASAVQLPDSDMTEANGRKKYSRDFLLTFAHQYSSLPVGIRMDTVTSTLFKDLAGKSYVIDREPHPSSARGSDRPTSRGDRRGPAMDDDKWLKSGVPYSPNRDAHMDLTNGPAINYRGGPGGAHGVLRNPRGALLVGPQSNAPQVPRSGSDADRWQQKGLIPSPVTPMQVMHKAEKKYVVGKVSDEEQAKQRQLKAILNKLTPQNFDKLFEQVKEVNIDNVSTLTGVISQIFDKALMEPTFCEMYANFCSHLAGALPDFSEDNEKITFKRLLLNKCQEEFERGEREEAEADKTEEEGEIKQTKEEREEKRVKARRRMLGNIRLIGELYKKRMLTERIMHECIKKLLGNYQNPDEENIEALCKLMSTIGEMIDHPKAKEHMDAYFDRMRNLSTSQLISSRVRFLLRDSIDLRKNKWQQRRKVDGPKKIDEVHRDAAQERHAQSSRSRGPVVSSLPRRGAPSMDYGSRGSAAPLVSPGPQQRGRGFGNQDIRYEQERHQFDRTVPLPQRSVKDEAITLGPQGGLARGMSLRGQPPVSNSELPSVVDQRRILSGPNGYNSVPSTTREDTSSRIPDRFSGRIATAAQSASSSHRPASQEGRSGNKSYSEEELREKSIATIREYYSAKDEKEVALCIEELNAPSFYPSLVSLWVNDSFERKDMERELLAKLFVGLYNGGYNLLSKPQLIEGLSSVLASLEDALSDSPRAAEYLGRLLARFVVEKILVLQDVGKLIEEGGEEPGHLVQEGIAADVLGAVLEWIRTEKGDSFLKEAKTSSNLKLEDFRPQHLKRSKLDAFMLT
What is the function of this protein?
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
What are the official names of this protein?
Eukaryotic translation initiation factor 4G, eIF-4G, eIF4G, Eukaryotic initiation factor 4F subunit p220, eIF-4F p220 subunit.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4G family.
Protein: GCC2_HUMAN
Sequence: MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSGWASYLHSWSGLR
What is the function of this protein?
Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi.  As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN.  May also play a role in transport between the recycling endosomes and the Golgi.  Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.
What are the official names of this protein?
GRIP and coiled-coil domain-containing protein 2, 185 kDa Golgi coiled-coil protein, GCC185, CLL-associated antigen KW-11, CTCL tumor antigen se1-1, Ran-binding protein 2-like 4, RanBP2L4, Renal carcinoma antigen NY-REN-53.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Protein: YNFB_ECOLI
Sequence: MKITLSKRIGLLAILLPCALALSTTVHAETNKLVIESGDSAQSRQHAAMEKEQWNDTRNLRQKVNKRTEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVITP
What are the official names of this protein?
UPF0482 protein YnfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: PROA_CLOAB
Sequence: MDIKDYVINIAKNSKLAAKKLSYADTNTKNKALIEMSKALLENKDYILSQNKIDIENAEKIGTSKALIDRLTLNDKRITDMAEALIKTSSLQDPIGEVIKMWKTPDELQIGQMRVPLGVIGIIYEARPNVTVDAAALCIKSGNSVILRGGKEAINSNTAIAKIIKNAVVTAGLPDGSIEFIDITDRETVNVMMRLNGLIDVLIPRGGAGLIKSVVENSSVPVIETGTGNCHVYVDKYADFDKAERIIINAKLQRPAVCNAMESLLVHKDVAHEFLPRISSKLKELKVQIRGCAATQKIVKDIVPATDEDFGKEFLDLILSVKVVDSLEEAIDHIFKYSTKHSEAIITENYTNAQRFLKEVDAAAVYVNASTRFTDGEQFGFGGEIGISTQKLHARGPMGLEQLTTTKYVIYGDGQIRK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_MYCLE
Sequence: MGIVGVGIDLVSIPDFAEQVSQPGTVFMTIFTPGERRDASVKSSSAVCHLAARWAVKEAVIKAWSGSRFAQRPMLPENIHRDIEVVNDMWGRPRVRLTGAIAKHLTDVTIHVSLTHEGDIAAAVVILEVL
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_FAGHA
Sequence: MEEFQRYLEPDRFRQHDFLYPLLFREYIYALAHDHGFNSYMLLENIGYDNKSSLLIVKRLITRMYQHNYLMISANDSNQNQFFGYNKNLHSQIISEGFAVIVEIPFSLRLISSFEGAEIVISYKLRSIHSIFPFLEDKLPHLNYTTDVRIPYPIHLEILIQTLRSRVKDASYLHLLRFFLHQYSNWNILIITTKSISIFSKSNPRFFLFLYNSHICQYESIFLFLGNQSSHLRIISSGVLFERLYLHKKIEHFAEVFANDFPVIPCFLKDPFMHYVRYQGKSILASKDTPLLMNKWKYYLVNLWQCHFYVWSHPGRIHINQLSKHSLDFWGYFSSVQLNPSVVRSQMLENSFLINNAPKKLDIIVPIIPLIGSLAKARFCNALGHPISKLTRADLSDFEILNRFLRICRNLSHYYSGSSKKKSMYRIKYILRLSCVKTLARKHKSTARAFLKKVGSEFVQEFFTEEEEFLSLIFPRTSFTLRRLYRGRVWYLDIIFINGLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NAL10_HUMAN
Sequence: MAMAKARKPREALLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDLEFSLYEAKIKNLVKGIQMNNVSFKIKHSNEKKSQSQNLFSVKSSLSHGPKEEQKCPSVHGQKEGKDNIAGTQKEASTGKGRGTEETPKNTYI
What is the function of this protein?
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476).  Displays anti-inflammatory activity (PubMed:20393137).  Required for immunity against C. albicans infection (By similarity).  Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233).  Contributes to T-cell-mediated inflammatory responses in the skin (By similarity).  Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990).  Exhibits both ATPase and GTPase activities (PubMed:23861819).
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection.
Protein: HSLV_THESQ
Sequence: MKFHGTTILVVRRNGQTVMGGDGQVTFGSTVLKGNARKVRKLGEGKVLAGFAGSVADAMTLFDRFEAKLREWGGNLTKAAVELAKDWRTDRVLRRLEALLLVADKENIFIISGNGEVIQPDDDAAAIGSGGPYALAAAKALLRNTDLSAREIVEKAMMIAGEICIYTNQNIVIEEV
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.