PharMolix/UniProtQA huggingface dataset:
Protein: YGFZ_VIBC3
Sequence: MDWQNRFSVLNLSSHDPLPELMLTHLTGWGAITLVGTDKKAYLQGQVTCNVVSLQEQQVTFGAHCDAKGKVWSVFRLFHHHDGYAMFQPQSAMEVELRELKKYAIFSKVTIAESSDIALGVMGSQADAWIDTVSETTGDVRRIAGGTAVRMSPQRWLLLVNAEQAEQYVNAWQGLHVEQSLWTRMDIEEAVPVVTQTAQNEHIPQALNVQAVDGISFTKGCYTGQETVARAKYRGINKRAMYIVKGNLSAPLSQDEPVVLERAVGENWRSAGALLTYYRFTDSIAIGLIVLPNDLEHDVELRLAAQPDTRWHIQPLPYSLSEE
What is the function of this protein?
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs.  It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
What are the official names of this protein?
tRNA-modifying protein YgfZ.
What is the protein family that this protein belongs to?
Belongs to the tRNA-modifying YgfZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_SALAI
Sequence: MTRRLFTSESVTEGHPDKIADQISDGILDALLAEDPRSRVAVETLITTGQVHVAGEVTTGAYADIPAIVRRTILDIGYDSSRKGFDGASCGVSVSIGSQSADIAQGVDNAFELRTGASESALDAQGAGDQGMMFGFACSETPELMPMPIALAHRLSRRLAQVRREGVVPYLRPDGKTQVTVEYEGLRPVRLNTVLVSSQHAADVSLDSLLTPDIRDHVIAPEVEGLGLGLDVEDYRLLVNPTGRFEVGGPMGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERCEAQVAYAIGKAHPVSLFVETFGTETVPVERIEKAVTEVFDLRPAAIIRDLQLLRPIYSQTAAYGHFGRELPDFTWESTDRAADLKSVAGA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_STAA8
Sequence: MSNKDIRVVVGMSGGVDSSVTAHVLKEQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIEVCNQIGIPYYAVNFEKEYWDKVFTYFLDEYKKGRTPNPDVMCNKEIKFKAFLDHAMNLGADYVATGHYARIHRHEDGHVEMLRGVDNNKDQTYFLNQLSQQQLSKVMFPIGDIEKSEVRRIAEEQGLVTAKKKDSTGICFIGEKNFKTFLSQYLPAQPGDMITLDGKKMGKHSGLMYYTIGQRHGLGIGGDGDPWFVVGKNLKDNVLYVEQGFHHDALYSDYLIASDYSFVNPEDNDLDQGFECTAKFRYRQKDTKVFVKRENDHALRVTFAEPVRAITPGQAVVFYQGDVCLGGATIDDVFKNEGQLNYVV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOME2_RAT
Sequence: MGEQPIFTTRAHVFQIDPSTKKNWVPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVREAARLARDKSQEKIETSSNHSQESGCETPSSTQASSVNGTDDEKASHASPADTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRSKIEELEEQCGEINREKEKNTQLKRRIEELESEVREKEMELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKGELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
What is the function of this protein?
Postsynaptic density scaffolding protein.  Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3.  By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release.  May also couple GRM1 to PI3 kinase through its interaction with AGAP2.  Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.  Required for normal hearing (By similarity).  Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway.  Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
What are the official names of this protein?
Homer protein homolog 2, Homer-2, Cupidin, VASP/Ena-related gene up-regulated during seizure and LTP 2, Vesl-2.
What is the protein family that this protein belongs to?
Belongs to the Homer family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Postsynaptic density. Synapse. Cell projection, stereocilium. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
Protein: CENPI_RAT
Sequence: MATPRLTRNSQQQNRISQGSNSRQTTLLDWKVKDKAGNSKSVLEESSSLEDSNHADDQTEDALQTAVEYFQKGPKKASLSKDSVLEKHLKTVENVAWNNGLAPEAIDILLNVALSGKFGNALSTRILKCMIPETHISEDSVVKAVSWLCVGKCSGNTKVLFYRWLVAMFDFIDHKKQINSLYGFFFVSLQDDTLCPYVCHLLYLLTKKENVKPFRARKLLDLQAKMGMQPHLQALLSLYKFFAPTLISVSLPVRKKIFFNNSKNLWTPALLAVKLRNQGIFPEPLKLQLGPTSGRSLKRKWNYHSVIPAVNSAKKECREKMSLFDYLSNDRSLPVEQLQSFPQLLENIHCLELPSQMSSVLNSSLLLHYVNCVKDESILLRLSYWLSQTLQEECVWYNMNDYQQEKEFINFLDMVIRVQCFLQEGFYSCEAFLYKSLPLWDGFSCRSQFLKLLAWIPFSSFSEIKPLLLDHLAPLFFTSSIYFKCSLLQCLKDLLQNWLLWLSTEAQVQPMTDSPLETTLGGSMDSVSQLIEYIGWLSMVAIRLESSSTLLVHFILDFYEKVCDIYINYDLPLVVLFPPVVFHSAFLSLDATILNQLCYIMYRYRDNLTAAKKKDLVQKAKSEFSISSKICKEFNYYLTALVHCLWSSRPFETGVYIDPQIIENTGETQYKHNLNFVHHPCLLNYAASFLLQESPEEMPVHLSSIRGKKWNWYLDHLYSEGFQGLNLFIKSSIDHSSVSKTEKNT
What is the function of this protein?
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.  Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores.  Involved in the response of gonadal tissues to follicle-stimulating hormone (By similarity).
What are the official names of this protein?
Centromere protein I, CENP-I, FSH primary response protein 1, Follicle-stimulating hormone primary response protein, Leucine-rich primary response protein 1.
What is the protein family that this protein belongs to?
Belongs to the CENP-I/CTF3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity).
Protein: SEC11_YEASA
Sequence: MNLRFELQKLLNVCFLFASAYMFWQGLAIATNSASPIVVVLSGSMEPAFQRGDILFLWNRNTFNQVGDVVVYEVEGKQIPIVHRVLRQHNNHADKQFLLTKGDNNAGNDISLYANKKIYLNKSKEIVGTVKGYFPQLGYITIWISENKYAKFALLGMLGLSALLGGE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Secretory protein 11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: UPPP_STAA1
Sequence: MFIIELIKGIILGVVEGLTEFAPVSSTGHMILVDDMWLKSSEFLGSQSAFTFKIVIQLGSVFAAAWVFRERFLEILHIGKHKHVEGENDQQRRSKPRRLNLLHVLVGMVPAGILGLLFDDFIEEHLFSVPTVMIGLFVGAIYMIIADKYSVKVKNPQTVDQINYFQAFVIGISQAVAMWPGFSRSGSTISTGVLMKLNHKAASDFTFIMAVPIMLAASGLSLLKHYQDIQIADIPFYILGFLAAFTVGLIAIKTFLHLINKIKLIPFAIYRIVLVIFIAILYFGFGIGKGI
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HCDS1_XANP2
Sequence: MLDAEVIAITGGAAGIGLAVAHAAIRAGARVALIDRDGACAQRAAAEFGAAAWGVGADVTDEAAITAAMAGAQRALGPLTGLVNNAGIAGFGSVHATEVETWSRIMAVNVTGTFLASKAALFGMLERGRGAIVNFGSVAGLVGIPTMAAYCAAKGAVVNLTRQMAADYSGRGIRVNVVCPGTVAGTDMGRQLLGTDCDPELEARRLAKYPMGRFGTPEDIAEAAVFLLSTKAAFVTGSVLAVDGGMTAI
What is the function of this protein?
Involved in aliphatic epoxide carboxylation (PubMed:9405410, PubMed:10411892).  Catalyzes the reversible oxidation of (2S)-2-hydroxypropyl-coenzyme M (S-HPC) to 2-oxopropyl-coenzyme M (2-KPC) (PubMed:10411892, PubMed:20302306).  The enzyme is highly specific for the S enantiomers (PubMed:10411892, PubMed:20302306).
What are the official names of this protein?
2-(S)-hydroxypropyl-CoM dehydrogenase 1, S-HPCDH 1, 2-[(S)-2-hydroxypropylthio]ethanesulfonate dehydrogenase 1, Aliphatic epoxide carboxylation component IV, Epoxide carboxylase component IV, SHPCDH1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: GCSPA_FLAPR
Sequence: MERARRLANKAILGRLVSQTKHNPSISSPALCSPSRYVSSLSPYVCSGTNVRSDRNLNGFGSQVRTISVEALKPSDTFPRRHNSATPEEQTKMAEFVGFPNLDSLIDATVPKSIRLDSMKYSKFDEGLTESQMIAHMQDLASKNKIFKSFIGMGYYNTSVPTVILRNIMENPGWYTQYTPYQAEIAQGRLESLLNFQTMVTDLTGLPMSNASLLDEGTAAAEAMAMCNNIQKGKKKTFIIASNCHPQTIDICKTRADGFDLKVVTSDLKDFDYSSGDVCGVLVQYPGTEGELLDYSEFIKNAHANGVKVVMASDLLALTILKPPGELGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRMMPGRIIGVSVDSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMFGVYHGPEGLKTIAKRVHGLAGTFAAGLKKLGTVQVQDLPFFDTVKVTCVDSKAIAEEAYKHKMNLRIVDKNTITVAFDETTTIEDVDTLFKVFALGKPVTFTAASIAPEVQDAIPSGLVRETPYLTHPIFNMYHTEHELLRYISKLQSKDLSLCHSMIPLGSCTMKLNATTEMMPVTWPAFADIHPFAPTEQAQGYQEMFKNLGDLLCTITGFDSFSLQPNAGAAGEYAGLMVIRAYHMARGDHHRNVCIIPVSAHGTNPASAAMCGMKIITVGTDSKGNINIEELRKAAEANKENLSALMVTYPSTHGVYEEGIDEICKIIHDNGGQVYMDGANMNAQVGLTSPGWIGADVCHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPYLPSHPVVATGGIPAPEQSQPLGTIAAAPWGSALILPISYTYIAMMGSQGITNASKIAILNANYMAKRLENHYPILFRGVNGTVAHEFIVDLRPLKTTAGIEPEDVAKRLIDYGFHGPTMSWPVPGTLMIEPTESESKAELDRFCDALISIRQEIAEIEKGNVDLNNNVIKGAPHPPQLLMADKWTKPYSREYAAYPAPWLRAAKFWPTTCRVDNVYGDRNLICTLQPPQEYEEKAEATA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating) A, mitochondrial, Glycine cleavage system P protein A, Glycine decarboxylase A, Glycine dehydrogenase (aminomethyl-transferring) A.
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GAK7_HUMAN
Sequence: MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDWKRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEKDSVSVSDALGSCIIDCNENTRKKSQKETEGLHCEYVAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELVGPSESKPRGTSHLPAGQVPVTLQPQKQVKENKTQPPVAYQYWPPAELQYRPPPESQYGYPGMPPAPQGRAPYPQPPTRRLNPTAPPSRQGSELHEIIDKSRKEGDTEAWQFPVTLEPMPPGEGAQEGEPPTVEARYKSFSIKMLKDMKEGVKQYGPNSPYMRTLLDSIAHGHRLIPYDWEILAKSSLSPSQFLQFKTWWIDGVQEQVRRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVRAICLRAWEKIQDPGSTCPSFNTVRQGSKEPYPDFVARLQDVAQKSIADEKARKVIVELMAYENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVRTFGGKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFDKNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQEQQPPLSQVFQGISQLPQYNNCPPPQAAVQQ
What is the function of this protein?
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle.  During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell.  Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA.  Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
What are the official names of this protein?
Endogenous retrovirus group K member 7 Gag polyprotein, HERV-K(III) Gag protein, HERV-K102 Gag protein, HERV-K_1q22 provirus ancestral Gag polyprotein, Gag polyprotein.
What is the protein family that this protein belongs to?
Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system).
Protein: RUVA_CAMLR
Sequence: MIVAIEGIVSKKEPTFVVLKTSSGVSYGVYVSLFCSGNFEKDQKIELSITQIIKEDSHKLYGFLDTNEQRMFELLIKISGIGATTAMALCSSLDTNTFYTALQSGDESVFKKVPGIGPKSAKRIIAELSDAKINIENSNQDHAQALAALLSLGFKQENILKVLRTCESQNTSELIKEALKKLA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: KRR1_DROVI
Sequence: MSDNESDGPTKQSTEPVDNAWSLKIPTFKAEDNPHGLVEESSFATLFPKYREKYLKEVWPLVQQCVAEHHLKAELDLVEGSMVVKTTRKTWDPYIIIKSRDMIKLMARSVPFEQAKRVLQDDIGCDIIKIGNLVHKKEKFVKRRQRLIGPNGATLKSIELLTDCYVLVQGNTVSALGPYKGLQQVRDIVLETMNNVHPIYNIKALMIKRELMKDPKLANEDWSRFLPKFKNKNISKRKQPKNKKPKKEYTPFPPAQPESKIDKQLATGEYFLNKEQKQAKKQQERSVKQAEAAKKQDERRNKDFVPPTEDAPSQSRKRPAETSKVDVDALKAKLMKANKKNRS
What is the function of this protein?
Required for 40S ribosome biogenesis.  Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.  Binds to RNA.  Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development (By similarity).
What are the official names of this protein?
KRR1 small subunit processome component homolog, KRR-R motif-containing protein 1, Protein dribble.
What is the protein family that this protein belongs to?
Belongs to the KRR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RRF_RHOOB
Sequence: MIDEALFEAEEKMEKAVTVAKDDLGSIRTGRANPGMFNRIGIDYYGAFTPITQLASINVPEARLVVVKPYEASQLNAIETAIRNSDLGVNPSNDGNLIRISVPQLTEERRRELVKQAKSKGEDAKVSVRNVRRKAMDELSRIQKDGEAGEDEVGRAEKELDKTTARYVAQVDELVKHKEAELLEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDH_THESW
Sequence: MSKVAIIGSGFVGATSAFTLALSGTVTDIVLVDLNKDKAIGDALDISHGIPLIQPVNVYAGDYKDVKGADVIVVTAGAAQKPGETRLDLVKKNTAIFKSMIPELLKYNDKAIYLIVTNPVDILTYVTYKISGLPWGRVFGSGTVLDSSRFRYLLSKHCNIDPRNVHGRIIGEHGDTEFAAWSITNISGISFNEYCSICGRVCNTNFRKEVEEEVVNAAYKIIDKKGATYYAVAVAVRRIVECILRDENSILTVSSPLNGQYGVKDVSLSLPSIVGRNGVARILDLPLSDEEVEKFRHSASVMADVIKQLDI
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCP2_HUMAN
Sequence: MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP
What is the function of this protein?
Involved in T-cell antigen receptor mediated signaling.
What are the official names of this protein?
Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA2_CARHZ
Sequence: MEKFVIEGKQRLTGRVKISGAKNAALPILAGALLTGGTVRLTEVPELTDIYTMLEVLKALGAKVTFSEGEVVLHTPEITSAEAPYEQVRKMRASFLVMGPLLARTGRARISLPGGCAIGARPIDLHLKGFEALGAKIEMGHGFIEATAPRLKGTTVYLDFPSVGATENIMMAAVLAEGQTIIENAAEEPEIVDLANFLNNMGAKIKGAGTKVIRITGVKDLDGVNHTVIPDRIEAGTFMIGAVATQGEVIVENVITDHLTPLIAKLIEAGAEVIEDEDQNALLVRSNGKLKPLDIKTLPYPGFPTDLQAQMMALLATVPGISVVTETVFENRFMHVTELNRMGAKIRIEGRSAFIEGVESLTGARVKATDLRAGAALVIAGLVADGVTEVGHIFHIDRGYERFEEKLRGLGAKIERVSD
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2, Enoylpyruvate transferase 2, UDP-N-acetylglucosamine enolpyruvyl transferase 2, EPT 2.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_METJA
Sequence: MLIVINYKTYNESIGNRGLEIAKIAEKVSEESGITIGVAPQFVDLRMIVENVNIPVYAQHIDNINPGSHTGHILAEAIKDCGCKGTLINHSEKRMLLADIEAVINKCKNLGLETIVCTNNINTSKAVAALSPDYIAVEPPELIGTGIPVSKANPEVVEGTVRAVKEINKDVKVLCGAGISKGEDVKAALDLGAEGVLLASGVVKAKNVEEAIRELIKFI
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPA_SYNS9
Sequence: MTLSASLSPQPFGRIVTAMVTPFDSSGAVDFQLAARLARHLVEQGSDGLLVCGTTGESPTLSWDEQLKLLEAVREAVGSSAQVLAGTGSNSTSEAVKATREAAAVGADGALVVVPYYNKPPQEGLEVHFRAIAEAAPTLPLMLYNIPGRTGCHIEAETVACLMDCPNIVSFKAASGTTEEVTALRLACGSRLAIYSGDDGLTLPMLSVGAVGVVSVASHVAGPQIRAMIDAYVEGEVGAALAQHEQLIPLFKALFATTNPIPVKAALEINGWSVGAPRPPLSSLPEAMRTTLSNTLSALRQT
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YACG_PSESM
Sequence: MSQPMTVQCPTCDTPVEWSAASPSRPFCSERCKLIDLGAWASEEHAIPVSPDAEDEMFSGDLEAPHRGH
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: PTH_PROM5
Sequence: MKDNEVFIIGLGNPGKQYIKSRHNIGFLLLETFSKKYDAQFTLKNKLKSRYTEFKINDSIYKLFMPHTYMNNSGDAVKAIVDWYKISLDKVFIIVDDIDLPLGKIRFRKKGSSGGHNGLKDIINKLQTENFNRIKIGIGSPPINETKKQLNTISHVLGNISSQENSTLEKVYQKVIESLEELDIKNEDYIISELNSFHK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_METC4
Sequence: MSKRDYYEVLGVAKTASESELKVAFRKLAMVHHPDRNPGDKEAEIKFKEVNEAYQCLSDGQKRAAYDRFGHAAFSQGGAGGPGFGNEFGDFMSDIFENFFGDGRAAPGGGAGRGRGGAPGRERGSDLRYNLEISLEEAFAGKTETIRIPTSIACETCSGTGAKAGSKPRTCSTCGGYGRVRAAQGFFAIERTCPNCHGRGEVVDDPCTACSGAGRVNRERTLSINVPAGVDDGLRIRLAGEGESGMRGGTAGDLYVFLSIKPHPFFQRDGADLFCRVPISMVTAALSGEITVPVIDGSQTQVRIPAGTQTGKQFRIKSKGMPVLRSREVGDLYIQVSVETPQNLTKRQRELLQEFDQSASDENHPESAGFFSKVRDFFVSGATRA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_PSEPF
Sequence: MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRAQAGDFMSLCMNPEFACEVTLQPLDRYPQLDAAILFSDILTIPDAMGQGLYFETGEGPRFKKVVSTLADIEALPIPDPHKDLGYVMDAVSTIRRELNGRVPLIGFSGSPWTLATYMVEGGSSKDFRKTKAMLYDNPQAMHLLLDKLAQSVTSYLNGQIQAGAQAVQIFDTWGGNLSAAAYQEFSLAYMKKIVSGLIREHDGRKVPVILFTKNGGLWLESIAEAGADALGLDWTCDIGNARARVGDKVALQGNMDPTVLYAKPEAIRTEVGRILASYGKGSGHVFNLGHGITPEVDPEHAGAFLRAVHELSAQYHE
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNY_FRACC
Sequence: MEGVLVVLLSLVLVVLSVLILAVARLVRATRVDKVPDPAPVVPRTPAARGVGDVTGPADFDEEPTVRVLPAPWEGSGAPATTDADSPADRDGTAARTGDSAVTAGRSDGGLRAAHGGSAEEAAQIVARAEREAAERLARAERDAAEIRRRGEEDVALLRERMLAEAAVETSRVQAAARESVRAEQEAARTEIAATRAAFDGEQQAWRTELQSREVAIAAREQRVEDRMASLDDHGRRLADRDRDLLDRENDLTRRTAEVADLERARHAALEQVAGLTAGQARGELIAVIEQEARREAALTVREIEARAEEEGEERARRIVTTAIQRVASDQTTESVVTVLHLPGDEMKGRIIGREGRNIRAFESVTGVNVLIDDTPEAVLLSCFDPVRREVGRITLAALVSDGRIHPHRIEEEYARAQLEVAERCVRAGEDALLETGISEMHPELVNLLGQLRYRTSYGQNVLAHLIESAHLAGIMAAELRMPLPLAKRAALLHDLGKALTHEIEGSHALIGADVARRYGEDEQVVHAIEAHHNEVAPRSICAVLTQAADQISGGRPGARRDSLESYVKRLERIEQIAGDRPGVDKVFAMQAGREVRVMVVPEEIDDLAAHLLARDVARQIEEELTYPGQIRVTVVRETRAVGTAR
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: Y2074_STAAS
Sequence: MAMTVKKDNNEVRIQWRVADIKIPTSEIKNITQDQDIHAVPKLDSKDVSRIGSTFGKTNRVIIDTEDHEYIIYTQNDQKVYNELTK
What are the official names of this protein?
UPF0457 protein SAS2074.
What is the protein family that this protein belongs to?
Belongs to the UPF0457 family.