PharMolix/UniProtQA huggingface dataset:
Protein: PT1_ASPRB
Sequence: MPSEVLTSYYDYPTHDQEAWWRDTGPLFGRFLKGAGYDVHTQYQYLVFFIKNILPSLGPYPARWRSTITPTGLPIEYSLNFQLNSRPLLRIGFEPLSRFSGTPQDPYNKIAAADLLNQLSKLQLHEFDTQLFNHFTNEFELSKSESESLQKQGGINGKSTVRSQTAFGFDLKGGRVAVKGYAFAGLKNRATGTPVGQLISNSIRNLEPQMHCWDSFSILNSYMEESDGWNEYSFVSWDCVDIERSRLKLYGVHNAVTWDKVKEMWTLGGRIENNATIKTGLELLQHMWSLLQINEGDRDYKGGFAADNGGKTLPIIWNYELNKGSPHPAPKFYFPVHGENDLQVSKSISEFFTHLGWQDHARQYPHLLRQIYPNQNISQTERLQAWISFAYNERTGPYLSVYYYSAERPPWGSDQVK
What is the function of this protein?
Prenyltransferase; part of the gene cluster that mediates the biosynthesis of echinulin family alkaloid (PubMed:29072465, PubMed:33381959).  The pathway begins with the biosynthesis of the cyclic dipeptide cyclo-L-Trp-L-Ala (cyclo-TA) by the NRPS echPS via condensation of L-alanine and L-tryptophan (By similarity).  The prenyltransferase echPT1 then catalyzes the first prenylation step, a reverse prenylation reaction at C2, to yield preechinulin (PubMed:29072465, PubMed:33381959).  Preechinulin is the substrate of the cytochrome P450 monooxygenase echP450 that catalyzes the formation of the double bond between C10 and C11 to produce neoechulin A (PubMed:33381959).  The unique prenyltransferase echPT2 functions as a competitive enzyme with echP450 for preechinulin metabolization and uses preechinulin for effective regiospecific prenylations.  Preechinulin is prenylated by echPT2 at C5 or C7.  C7-prenylation leads to accumulation of tardioxopiperazine B without further modification by echPT2.  In contrast, the C5-prenylated tardioxopiperazine A can be prenylated again by echPT2, predominantly at C7 to form echinulin or less frequently at C4 to give variecolorin L.  EchPT2 accepts also neoechilunin A to produce varlecolorin G (prenylation at C5) or isoechinulin A (prenylation at C7).  EchPT2 further converts isoechinulin A into dehydroechinulin.  Moreover, a yet unidentified enzyme can also convert neoechilunin A into neoechilunin B by introducing a double bond between positions C14 and C17 and thus provides a further substrate to echPT2 for C5 and C7 prenylation (PubMed:29072465, PubMed:33381959).
What are the official names of this protein?
Echinulin prenyltransferase 1, EchPT1, Echinulin biosynthesis cluster protein echPT1.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: TRMB_LISW6
Sequence: MRVKHKPWAKDRLEEFPAIYIKNPEDFKGRWQEVFGNNNPIHIEIGSGKGQFISGMAKANPEINYIGIEMIESVLVSALDKAIEADVPNLRLVARDAKLLEECFEKGEIAQIYLNFSDPWPKKRHTKRRLTNPTFLTIYERLLPKAGEIHFKTDNRSLFEYSLVAFSEYNMLLTFVSLDLHNSDYEGNIKTEYEEKFSAKGFPIYRLEAKFDRN
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: PGLI_CAMJE
Sequence: MPKLSVIVPTFNRQVLLEKAIKSIQNQDFKDLEIIVSDDNSSDDTKSVVQNLQKDDDRIKYFLNQNYKQGPNGNKNNGLDQASGEFVTFLDDDDELLSGALSTLMQKANEGYAHVFGNCLIEKEGNLSKEFSGKGLEKDSEISKKDFLMAKFSGEFFSVFKKSLLENKRFNEEFYGNEATLWVNLYKEKSFYIHKAFRIYRIFRQDSVTLGASKNAYRVYLGYLELAKILENELRMSKDKDYKKTCASYYKMAAYYAKLAKNYKALYKCLFKSLSIKINAPALILLILSIIPNNMIEKLSKIRVALCKN
What is the function of this protein?
Glucosyltransferase that adds he final branching glucose to complete the final heptasaccharide structure in the N-linked protein glycosylation pathway.
What are the official names of this protein?
GalNAc(5)-diNAcBac-PP-undecaprenol beta-1,3-glucosyltransferase, Protein glycosylation I.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CALM2_SOYBN
Sequence: MADQLTDDQIAEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKVMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin-2, CaM-2.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: GLRX_BPT4
Sequence: MFKVYGYDSNIHKCVYCDNAKRLLTVKKQPFEFINIMPEKGVFDDEKIAELLTKLGRDTQIGLTMPQVFAPDGSHIGGFDQLREYFK
What is the function of this protein?
Serves as a reducing agent for the phage-induced ribonucleotide reductase, but not for the bacterial ones.  This specificity may be the result of sequence differences around the redox-active disulfide bond.  The oxidized form accepts electrons from bacterial glutathione and will, in turn, reduce other small disulfides.  Can also be reduced by NADPH and by bacterial thioredoxin reductase.
What are the official names of this protein?
Glutaredoxin, Thioredoxin.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
Protein: PBX3_MOUSE
Sequence: MDDQSRMLQTLAGVNLAGHSVQGGMALPPPPHGHEGADGDGRKQDIGDILHQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGGSSDNSIEHSDYRAKLTQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGANSLYSPHNLNANGGWQDATTPSSVTSPTEGPGSVHSDTSN
What is the function of this protein?
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.
What are the official names of this protein?
Pre-B-cell leukemia transcription factor 3, Homeobox protein PBX3.
What is the protein family that this protein belongs to?
Belongs to the TALE/PBX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS8_CORDI
Sequence: MKDLTLNDLPIREELRGQSAYGAPQLDVDVRLNTNENPYPPSEALVEELARVVAEQASNLNRYPERDAVELRTELARYITKCTGVPVTYEQLWAANGSNEVLQQLLQAFGGPGRTVLGFQPSYSMHPILAQGTQTTFINCPRDKEFRIDVDAALAAITTHQPNIVFVTTPNNPTGDVTSLDTIKKILDVAPGIVIVDEAYAEFSEQPSAISLLENYPTKLVVSRTMSKAFDFAGGRLGYFVAHKAFIDAVMLVRLPYHLSQLSQAAAIVALRHSEETLATVAKLVAERKRVQQGLLELGFEIVPSESNFLFFGHFEDQHAAWQAFLDRKVLIRDVSVSGYLRATVGLPEENDAFLNAAREVAQQFL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: CYSH_ERWT9
Sequence: MALLELSELNQLPKVERVMALAEINNRLDKLSAEDRVLWGLENLPGQAVLTSSFGIQAAVSLHLVTRQKPDIPVILTDTGYLFPETYRFIDQLTEKLDLNLQVFRAEQSPAWQEARYGKLWEQGVEGIERYNQINKVEPMNRALETLQGQTWFAGLRRDQSGSRAHLPVLAVKKGIFKLLPIIDWDNRQVYQYLQQHGLSYHPLWEQGYLSVGDTHTTRKWEPGMAEEETRFFGLKRECGLHE
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHMA_SALG2
Sequence: MNALLSNPFKEGLREGDTQIGLWLSSTTSYMAEIAATSGYDWLLIDGEHAPNTVQDLYHQLQAIAPYASQPVIRLIEGSKALIKQVLDIGAQTLLIPMVDTAEQARQVVSATRYPPLGQRGVGASVARAARWGRIDNYMAQANESLCLLVQVESKVALENLDAILEVEGIDGVFIGPADLSASLGYPDNAGHPEVQRIIESCIYRIRAAGKAAGFLAVDPAMAQKCLAWGANFVAVGVDTMLYTEALDSRLAMFKSVQSVSTAKRSY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
What are the official names of this protein?
2-keto-3-deoxy-L-rhamnonate aldolase, KDR aldolase, 2-dehydro-3-deoxyrhamnonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.
Protein: EFTU_MYCGA
Sequence: MAKERFDRSKPHVNIGTIGHIDHGKTTLTAAICTVLSKAGTSEAKKYDEIDAAPEEKARGITINTAHVEYATQNRHYAHVDCPGHADYVKNMITGAAQMDGGILVVSATDGPMPQTREHILLARQVGVPKMVVFLNKCDVADDPEMQELVEMEVRDLLKSYGFDGDNTPVIRGSALGALNGEPAWEEKIHELMKAVDEYIPTPDREVDKPFLLPIEDTMTITGRGTVVTGRVERGQLKVGEEVEIVGITDTRKVVVTGIEMFRKELDAAMAGDNAGILLRGVDRKDVQRGQVLAKPGSITPHKKFRAEIYALKKDEGGRHTAFLNGYRPQFYFRTTDVTGSIQLKEGTEMVMPGDNTEIIVELISSIACEKGSKFSIREGGRTVGAGTVVEVLE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_SALCH
Sequence: MIEFGNFYQLIAKNHLSHWLETLPAQIAAWQREQQHGLFKQWSNAVEFLPEMTPWRLDLLHSVTAESETPLSEGQLKRIDTLLRNLMPWRKGPFSLYGVDIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHLWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALKAFDTVFSMGVLYHRRSPLEHLWQLKDQLVNEGELVLETLVIDGDENTVLVPGDRYAQMRNVYFIPSAPALKKWLEKCGFIDVRIADVCVTTTEEQRRTEWMVTESLADFLDPNDRSKTVEGYPAPQRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: DLTA_LACCB
Sequence: MIDNVITAIDRVAAEHPTRVAYDYEGTQYTYAQLKEGSDRLAGFFAETLPEHEPIIVYGGQTFDMVEVFLGLSKSGHAYIPIDTHSPNERITQVQDVAHTPAIIEVAPLPIAVPDVQIIRAPELHEAEKTHALISSLQHAVVGDDNYYIIFTSGTTGKPKGVQISHDNLLSYVNWNISDFGLKEGVVAMSQPPYSFDLSVMDLYPTLVLGGTLKALPKEVTDNFKTLFATLPKLGLNEWVSTPSFAEIALLDPNFNQDNYPDLTHFLFCGEELVNKTAQELITRFPKATVYNTYGPTETTVAVTGMAITQDIVDQYPRLPIGFAKPDTEIFVVDEQGNQVSAGTEGELMIVGPSVSKGYLNNPEKTAKAFFNVGSQRGYRSGDLATMTEDGMIFYRGRTDFQVKLHGYRIELEDVDHNLNQVSYIKQASTVPRYNKDHKVAQLIAFAVAKPNDFESDMKLTQAVKAELGKMVMEYMIPQRIIYRDKLPLTANGKVDRKALIAEVNH
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERC_RALPJ
Sequence: MNQADRALQASQARVYNFSAGPAVLPLEVLEQAKEEMVSWHGSGMSVMEMSHRGREFENILAAAFSDLRQLLAVPDNYEILFLQGGAIAENAIVPLNLMRRLSADAPKADYVVTGTWSVKSQQEARKYGEVNIAATSETERFHKIPDVSSWKLSSDAAYVHLCTNETIVGVEYQETPDVGQAHGRVVVSDVSSHILSRPIDWNGYQVLYGGAQKNIGPAGLTIAIVRKDLLGHAHPLCPSAFNWRLVAENGSMYNTPPTYAIYIAGLVFQWIKRQGGVEALETRNIIKSKMLYDFIDASSFYRNEIHPTCRSRMNVPFFLNDESRSEAFLAQARERGLVQLKGHKSVGGMRASIYNAMPLEGVEALVDFMREFERVSA
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CWC22_MAGO7
Sequence: MSSPDARDARSPSPRPRSPSPAAPSRSWSRSRHESPSRSPAPMRERREEEGNEQRSPRQIAHHPRSPRGSDRRAEPRRRDAGGGGGDKYRPAKARKQRSPPPAATEEQKQAAAKAEYERLLTARSGGTYVPPARLRALQAQITDKTSMAYQRMAWDALKKSINGLINKVNVSNIKPLVPELFNENLVRGRGLFCQSAIKAQAASLPFTPIYAALVAVVNTKLPQVGELLLRRLVLRFRKAFRRNDKAVCLSATTFVAHLVNQQVAHEMVAGQMLLLLLNKPTDDSVEIAVGLTREVGQFLEEMNAAIANVVFDRFRDILHEADIAKRTQYMIEVLFQTRKDRFKDNPAIRDELDLVEEDDQIKHFVELDGELDAQDGLNIFKFDPEYEENEEKYKKLKAEILGEGSDYEDDSDDEGSDSSDDEPAAAEQKAMDIQDRSNADLVALRRTIYLTLMSSMDPEEAVHKLMKINLPQGLEGELPSLVVESCAQERTYSKFYGAIGERLAKINRLWTDLFEKSFEHYYTSIHRYETNRLRNIARFFGHMFSSDAIGWHCLSVIHLNEEETTSASRIFIKILFQEISEAMGMPKLHTRTKDAALQPYMEGLFPRDTARNIRFSINYFTSIGMGVLTEDSREFLQNMPKPALPAPPPDSDSESSSSYSSYTGSSYSRSRSPSPRRRSYSRSRSRSVTPRRTNSNGRNNARSPSRSVSRSISRSRSPAPIRGRSYSRSVSRSRSRSYSRSVSRSPTPPRRQAPAQQRGRQRSYTPSDRSRSRSYSRSRSPRGRSYTRSPDRAGPQASTAPRSGGPPRKAGSVDNRSPLSRSPSGSRSPSPRRRRDSPSRSPVRDRESGGRAAAAAPGNSEARRGRSYSRSPSRTRSPSPAPSRRRRRDSSSDASAPRKRRRESSR
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC22.
What is the protein family that this protein belongs to?
Belongs to the CWC22 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL22_BLOPB
Sequence: MRTISRCRYIRSSAQKLRLVVNTIRGKKVSQALDILKYTNKKSAELVKKTLESAIANAEHNDNSDINNLKIIKIFVDSGPIIKRIMPRAKGRSDKIMKRTSHLTIVVSN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: ICAM1_PANTR
Sequence: MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPPKVILPRGGSVQVTCSTSCDQPDLLGIETPLPKKELLLGGNNWKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKDLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVERDHHGANFSCRTELDLRPQGLQLFENTSAPHQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVLEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSRETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPVGPRVQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQASGNPLPELKCLKDGTFPLPVGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIRKYRLQQAQKGTPMKPNTQATPP
What is the function of this protein?
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).  During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
What are the official names of this protein?
Intercellular adhesion molecule 1, ICAM-1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. ICAM family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: FADB_ACIBC
Sequence: MIHAGNAITVQMLADGIAEFRFDLQGESVNKFNRATIEDFKAAIAAVKANNDIKGLVVTSGKSTFIVGADITEFGQNFAQGEKAIVDWLMPVHEIFNSFEDLDLPKVAAINGMALGGGFEMCLVCDYRVMSEAAQVGLPEIKLGIYPGFGGSVRLSRLIGIDNAVEWMAMATPKKPAAALKDGAVDAVVAADKLLDAATDLVKQAISGRLNWKAKRQEKLEAVKLNPLEQMMAFNTAKGAVLAKANPAQYPAPKLLLDSLQAGASLARDEALKAEAEGFAKAAVTPQAEALIGLFINDQVVKKASKQHEKGAHPVNQAAVLGAGIMGGGIAYQAASKGTPIIMKDIGNPQLALGMKEANNLLTKQVERKKMKPAQMGETLARIRPTLSYEEFKEVDIVIEAVTENPKVKEIVLAETEKNVRENTIIASNTSTISITRLAKALQRPENFVGMHFFNPVHMMPLVEVIRGEKTSEEAIATTVVLAQKMGKTPIVVNDCPGFLVNRVLFPYFGAFDLLVKDGADFQQIDNVMSKFGWPMGPAYLIDVVGIDTGVHGAEVMAEGFPDRMKPDYKGAIEAMYEAKRLGQKNDVGFYKYELDKKGKKAKTVDPTAYEVIAPFVTGEKREFDNQEIIDRMMLALCNETVRCLEDNIVATASEADMAMIMGIGFPPFRGGPCRYIDQTGVAEYVALCDKYAHLGKAYEAPQMLRDMAANNKKFYG
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: BCL2_CHICK
Sequence: MAHPGRRGYDNREIVLKYIHYKLSQRGYDWAAGEDRPPVPPAPAPAAAPAAVAAAGASSHHRPEPPGSAAASEVPPAEGLRPAPPGVHLALRQAGDEFSRRYQRDFAQMSGQLHLTPFTAHGRFVAVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIATWMTEYLNRHLHNWIQDNGGWDAFVELYGNSMRPLFDFSWISLKTILSLVLVGACITLGAYLGHK
What is the function of this protein?
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells.  Regulates cell death by controlling the mitochondrial membrane permeability.  Appears to function in a feedback loop system with caspases.  Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
What are the official names of this protein?
Apoptosis regulator Bcl-2.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm.
Protein: SOMA_LITCT
Sequence: MASGLGSSLVLLVVICLQSPQGFNAFPQMSLSNLFTNAVIRAQHLHQMVADTYRDYERTYIPEDQRFSNKHSYSVYCYSETIPAPTDKDNTHQKSDIDLLRFSLTLLQSWMTPIQIVNRVFGNNQVFGNIDRVYDRLRDLDEGLHILIRELDDGNVRNYGVLTFTYDKFDVNLRSEEGRAKNYGLLSCFKKDMHKVETYLKVMKCRRFVESNCTF
What is the function of this protein?
Growth hormone plays an important role in growth control.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DCR1A_MOUSE
Sequence: MLEDTWEEEIWEYKSKRKPKPVHPNNCSENISESVEKSTDGKHQSKGNEKRTSENPGKTKDHKVCLAETDSQISAGSSQSSSCRDESQQSQNKETTPKKQHRTRRGKQVTPKVRPVYDGYCPSCQMPFSSLLGQTPQWHVFECLDSPPISDTECPEGLLCTSTIPSHYKKYTHILLAQSRDSKEPLGSPSDALAGLFAAAAPGSPCNLEERRSMTLKTENLRKVSDHSLLMMQYLETSQPSAEINRKNVSSPCSQTSPVPQCAEFVKRDQLVGGGSPLAEVALNSQSKSGSMGLPLPENDTDSCEISYSPLHSDEETYDIDQELDDSQQELFFTQSSKDSSLEEDGSAIFENLHGPSPKEAEGIRPTAKSLVAQARCSAPSEGSTLSDSFLLLSYTSNRLSQEDLPHTDAAFHLLSPALAVGGAASNYQTSKAKLDEPEKFLSLASSHQQQKIETSAVGNQTSLPLLTRARSKPLEKEGGKCLPLHPTQSQTRGSPRKGLGAPGANCACRNAQKRSSMPLDKPLGTSPSSPKCSPSQPSKKVMKQMDIGVFFGLPPKRQETSLRESASEGPNVSPVVSPNQKRPRLCKRKAQSSLSDLEFDAKNLNESQHSVGLSGEKRQHRRKRHKTSNSPREGPCQRRSGHLMNNPELGPVSLSKAFVRRTRGRTQRGNMNISESSGAGEVRRTCPFYKRIPGTGFTVDAFQYGEIEGCTAYFLTHFHSDHYAGLSKDFTRPVYCSEITGNLLKKKLRVQEQYIRQLPMDTECVVDSVKVVLLDANHCPGATMILFQLPNGAVILHTGDFRADPSMERSRLAGRKVHTLFLDTTYCSPEYTFPSQQEVIQFAINTAFEAVTLNPRALVVCGTYCIGKEKVFLAIADVLGSKVGMSQEKYKTLQCLNIPEVSSLITTDMCDSLVHLLPMMQINFKGLQSHLKKCGGKYDQILAFRPTGWTHSNNITSTADIIPQTRGNISIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGSFRSRNTMEKYFKEWRLEAGY
What is the function of this protein?
May be required for DNA interstrand cross-link repair.  Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.
What are the official names of this protein?
DNA cross-link repair 1A protein, Beta-lactamase MBLAC2, SNM1 homolog A.
What is the protein family that this protein belongs to?
Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
What are the subcellular locations of this protein?
Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1 (By similarity).
Protein: AROK_STRPZ
Sequence: MTKVLLGFMGVGKTTVSKHLSMHCKDMDAIIEAKIGMSIAAFFEQHGEIAFRTIENQVLKDLLFANDNSVIVTGGGVVVLQENRQLLRKNHQHNILLVASFETLYQRLKHDKKSQRPLFLKYSKEAFYEFYQQRMVFYEGLSDLVIRVDHRTPEEVANIIEGY
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_STRA3
Sequence: MIANQTIVDIVTQVVTPAIQAPFELVDVEYEKMGGDYVLSILIDKPGGITVEDTAQLTDVVSPLLDTIQPDPFPEQYMLEVSSPGLERPLKTAEALSNAVGSYINVSLYKSIDKVKIFEGDLLSFDGETLTIDYMDKTRHKTVDIPYQTVAKARLAVKL
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEH1_CAEBR
Sequence: MSADKSPYQIEPYKTVGAHRDLIHCVSFDPHGRRMATCASDMTMAIWDRQPDGNWRRSAHWKCHGGAVWRVIWAHPEFGQIVASCSYDRTIVIWEEQIVRTEKDLKCKESQWIRRTIISDNRSDVTDICFSPRHLGLSLASCNVLGAVRIYEAPDVVDASRWNLIHELQAFHTRCGCVTWSLSRMHRPLIAVGSDEKKAGGKERVVIYENIDGLRKWQRIHSLVFDMPCPITDLKFSPISMVDSHQLAIASGDVHVFNIKVPRTAILEEDGVDNPIHLADYSFQRVALLGDQRKAWRIRYNLIGSVITSTSLDGTLRSWKSLFVNQWVKLSEMNVDDYVPTADEVHKIVEAKTTERLPSQLDKVYF
What is the function of this protein?
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
What are the official names of this protein?
Nucleoporin SEH1, GATOR complex protein SEH1, Nuclear pore complex protein 18, SEC13-like protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC13 family.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Lysosome membrane.
Protein: RL5_PYRAE
Sequence: MPSWKELVLVKGHPMQRIYIEKVVVNIGVGASGEKLEKAAGLLKELTGAEPSRRRAKKSIKDFGIRKGEPIGVAVTLRRDQAVNFLMRALQAVNNRVKKTSFDDRGNVCFGIKEHILLPGVKYDPAVGIWGMDVCVKLAKPGLRVQLRRRRRSKVGKRQLVTKEEAIEFFQKVLGVQVD
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.