PharMolix/UniProtQA huggingface dataset:
Protein: RISB_CHLSY
Sequence: MTIYEGTYIGSGLRIAIVVSRWNDLITNRLLEGARDGLLRHGVAADHIDIAWVPGSFELPLVCHRLAESSRYDAIIALGAVIRGATTHHEHVAAAASSGIAQVSLQTGVPCIFGVITTDNIEQAIERAGTKAGNKGFEAATAAIEMATLLQRLNG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: ARL4C_HUMAN
Sequence: MGNISSNISAFQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPTIGFNTEKIKLSNGTAKGISCHFWDVGGQEKLRPLWKSYSRCTDGIIYVVDSVDVDRLEEAKTELHKVTKFAENQGTPLLVIANKQDLPKSLPVAEIEKQLALHELIPATTYHVQPACAIIGEGLTEGMDKLYEMILKRRKSLKQKKKR
What is the function of this protein?
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).  GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.  May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway.  Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form.  Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.
What are the official names of this protein?
ADP-ribosylation factor-like protein 4C, ADP-ribosylation factor-like protein 7, ADP-ribosylation factor-like protein LAK.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cell projection, filopodium. Cell membrane. Cytoplasm.
Protein: DOLP_ECO57
Sequence: MKALSPIAVLISALLLQGCVAAAVVGTAAVGTKAATDPRSVGTQVDDGTLEVRVNSALSKDEQIKKEARINVTAYQGKVLLVGQSPNAELSARAKQIAMGVDGANEVYNEIRQGQPIGLGEASNDTWITTKVRSQLLTSDLVKSSNVKVTTENGEVFLMGLVTEREAKAAADIASRVSGVKRVTTAFTFIK
What is the function of this protein?
Plays an important role in maintaining outer membrane integrity.
What are the official names of this protein?
Outer membrane lipoprotein DolP.
What is the protein family that this protein belongs to?
Belongs to the lipoprotein DolP family.
Protein: ACPS_ECO8A
Sequence: MAILGLGTDIVEIARIEAVIARSGERLARRVLSDNEWAIWKTHHQPVRFLAKRFAVKEAAAKAFGTGIRNGLAFNQFEVFNDELGKPRLRLWGEALKLAEKLGVVNMHVTLADERHYACATVIIES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATC_ARATH
Sequence: MTSRYWVVSLPVKDSASSLWNRLQEQISKHSFDTPVYRFNIPNLRVGTLDSLLALGDDLLKSNSFVEGVSQKIRRQIEELERISGVESNALTVDGVPVDSYLTRFVWDEAKYPTMSPLKEVVDNIQSQVAKIEDDLKVRVAEYNNIRGQLNAINRKQSGSLAVRDLSNLVKPEDIVESEHLVTLLAVVPKYSQKDWLACYETLTDYVVPRSSKKLFEDNEYALYTVTLFTRVADNFRIAAREKGFQVRDFEQSVEAQETRKQELAKLVQDQESLRSSLLQWCYTSYGEVFSSWMHFCAVRTFAESIMRYGLPPAFLACVLSPAVKSEKKVRSILERLCDSTNSLYWKSEEDAGAMAGLAGDSETHPYVSFTINLA
What is the function of this protein?
Subunit of the peripheral V1 complex of vacuolar ATPase.  Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
What are the official names of this protein?
V-type proton ATPase subunit C, V-ATPase subunit C, Vacuolar H(+)-ATPase subunit C, Vacuolar proton pump subunit C.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase C subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein.
Protein: UREG_SHEHH
Sequence: MTELEYKQPLRIGVGGPVGSGKTALLEVLCKALRNKYQIAVVTNDIYTQEDAKILTRAEALDADRIIGVETGGCPHTAIREDASMNLAAVEELAKRHKNLDVVFVESGGDNLSATFSPELADLTIYVIDVAEGEKIPRKGGPGITRSDLLIINKIDLAPYVGASLVVMDQDTKRMRPEKPYIFTNMKTGKGVPEILTFIETAGMLNI
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAE1_VANPO
Sequence: MGDHFDDVWGSGSENESEGLTNDIKKLREIHNNRGYLDGVTDSKDMNLQNGFDEGFPTGSVLGYTVGELIGTMMSLNAVYVEDEQLKSDLESAQKELRVNEVLTKSMFNEQLDLDGEHPVLLKWKKIVEGYEEKYLK
What is the function of this protein?
The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery.  May be required for biogenesis of the large ribosomal subunit and initiation of translation.
What are the official names of this protein?
Protein YAE1.
What is the protein family that this protein belongs to?
Belongs to the YAE1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GRP75_BOVIN
Sequence: MISASRAAVSRFVGTAASRGPTAARHQDGWNGLSHEAFRIVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKDNQKEEKQ
What is the function of this protein?
Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis.  Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU.  Regulates erythropoiesis probably via stabilization of ISC assembly.  May play a role in the control of cell proliferation and cellular aging.
What are the official names of this protein?
Stress-70 protein, mitochondrial, 75 kDa glucose-regulated protein, GRP-75, Heat shock 70 kDa protein 9.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus, nucleolus.
Protein: COAD_MYCA9
Sequence: MTGAVCPGSFDPVTLGHLDVFERAAAQFDEVIVAVLINPNKAGMFTVDERIEMIRESTADLPNLRVESGQGLLVDFVRERGLNAIVKGLRTGTDFEYELQMAQMNKHIAGVDTFFVATAPAYSFVSSSLAKEVATYGGDVSALLPASVHQRLLGKLRGQAQ
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAG_YERPY
Sequence: MIEQPRICVQVQSIYVETQSIPEEERFVFAYTVTVRNLGRSNVQLLGRYWLITNSNGRQTEVQGEGVIGEQPLILPGNEFQYTSGAVLETPLGTMEGHYEMIDHLGQAFRTVIPVFRLAIPALIH
What are the official names of this protein?
Protein ApaG.
Protein: RR8_PLAOC
Sequence: MGRDTIADIITSIRNADMDKKGRVRIGYTNIAENIIKILLREGFIENVRKHRESNKYFLVSTLRHRRNRKRPYKTILKRISRPGLRIYSNYQRIPRILGGIGIVILSTSRGIMTDREARLEGIGGEILCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AVP_VIGRR
Sequence: MGAAILPDLGTEILIPVCAVIGIAFALFQWLLVSKVKLSAVRDASPNAAAKNGYNDYLIEEEEGINDHNVVVKCAEIQNAISEGATSFLFTEYKYVGIFMVAFAILIFLFLGSVEGFSTSPQACSYDKTKTCKPALATAIFSTVSFLLGGVTSLVSGFLGMKIATYANARTTLEARKGVGKAFITAFRSGAVMGFLLAANGLLVLYIAINLFKIYYGDDWGGLFEAITGYGLGGSSMALFGRVGGGIYTKAADVGADLVGKVERNIPEDDPRNPAVIADNVGDNVGDIAGMGSDLFGSYAESSCAALVVASISSFGLNHELTAMLYPLIVSSVGILVCLLTTLFATDFFEIKAVKEIEPALKKQLVISTVLMTIGVAVVSFVALPTSFTIFNFGVQKDVKSWQLFLCVAVGLWAGLIIGFVTEYYTSNAYSPVQDVADSCRTGAATNVIFGLALGYKSVIIPIFAIAISIFVSFTFAAMYGIAVAALGMLSTIATGLAIDAYGPISDNAGGIAEMAGMSHRIRERTDALDAAGNTTAAIGKGFAIGSAALVSLALFGAFVSRASITTVDVLTPKVFIGLIVGAMLPYWFSAMTMKSVGSAALKMVEEVRRQFNTIPGLMEGTAKPDYATCVKISTDASIKEMIPPGALVMLTPLVVGILFGVETLSGVLAGSLVSGVQIAISASNTGGAWDNAKKYIEAGASEHARSLGPKGSDCHKAAVIGDTIGDPLKDTSGPSLNILIKLMAVESLVFAPFFATHGGLLFKIF
What is the function of this protein?
Proton-translocating inorganic pyrophosphatase that contributes to the transtonoplast (from cytosol to vacuole lumen) H(+)-electrochemical potential difference.  It establishes a proton gradient of similar and often greater magnitude than the H(+)-ATPase on the same membrane.
What are the official names of this protein?
Pyrophosphate-energized vacuolar membrane proton pump, Pyrophosphate-energized inorganic pyrophosphatase, H(+)-PPase, Vacuolar H(+)-pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast membrane.
Protein: UBP10_SCHPO
Sequence: MSENKDKNNILKRHIEEDNNIDNGKRKKLELGKDMEDVHDIASKEMEEHETTPIISQNLYLDTINRKLLDFDFEKVCSVSLTNLSVYACLVCGRYFQGRGPSSHAYFHALTENHHVFVNCSTLKFYVLPESYQVESSALQDIAYVMRPTFTKLEVQRLDHTPQLSYDLMLKPYVPGFVGMNNIKNNDYFNVVIHMLAHVKPFRNYFLLKNFDNCPQLVQRLAILIRKLWNHKAFKSHVSPQELIQEVTVLSHKKYSINEQKDPVEFLSWFLNTLHNCLGGKKSTIAKPTSIVHYSFQGFVRIESQKIRQHAEKGEQVVFTGDRVIQTNVVPFLYLTLDLPPKPIFQDEFEGNIIPQVELKEILNKYNGVHTQELAGMRRRFHLMTAPPYFIFHIKRFMKNNYFTERNQTIVTFPLDDFDMSPFIDDSFIQSNPKISTKYNLVANIIHESVTHAEEEFHNFRIQIRNPSTNKWYQIQDLYVEEISSDMIRLGESFIQLWERSS
What is the function of this protein?
May play a role in mRNA splicing.  It is unsure if the protein really exhibits hydrolase activity.  Could be a competitor of ubiquitin C-terminal hydrolases (UCHs) (By similarity).
What are the official names of this protein?
Probable mRNA-splicing protein ubp10, Probable inactive ubiquitin-specific-processing protease 10.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HPLN2_HUMAN
Sequence: MPGWLTLPTLCRFLLWAFTIFHKAQGDPASHPGPHYLLPPIHEVIHSHRGATATLPCVLGTTPPSYKVRWSKVEPGELRETLILITNGLHARGYGPLGGRARMRRGHRLDASLVIAGVRLEDEGRYRCELINGIEDESVALTLSLEGVVFPYQPSRGRYQFNYYEAKQACEEQDGRLATYSQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGGRGRPGIRSYGPRDRMRDRYDAFCFTSALAGQVFFVPGRLTLSEAHAACRRRGAVVAKVGHLYAAWKFSGLDQCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSFGFPRPQQAAYGTYCYAEN
What is the function of this protein?
Mediates a firm binding of versican V2 to hyaluronic acid.  May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization.  Binds to hyaluronic acid (By similarity).
What are the official names of this protein?
Hyaluronan and proteoglycan link protein 2, Brain link protein 1.
What is the protein family that this protein belongs to?
Belongs to the HAPLN family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: IF2_ANAMM
Sequence: MLMSDVEKFGGDCGSSGGSGRPTLKLGTRASTLAKTPTSTGGRTFMTVEVRSRKRKASGASPAEGVGYGTSPYTSDDNRQGQISRSATCSLTAREQLSRINAIHTADSISAQKEAAKKLRDEEEVEVAPPEGESVIDEPDSVKEPAAAADAVADVATPVLGDIAPGAAGTRPGRGGHDDKGKRYSYQGAGGKIKEKEGGGGVKKAAASRASSKHIKLDIENALSGTEERYVLMASSRRRGGSKSDRRISRDVVIPDEIEVKALAAAMAEKVGDVLRVLSHMGVEARQNTAIGSDVASEVAERFSHRPKVVSKIQMERELSDISDSGLALEPRPPVVTVMGHVDHGKTSLLDVLRKSNVAEKEFRGITQHIGAYQIDVDGKKITFLDTPGHEAFSDMRARGTNVTDIVVLVVAADDGVMPQTVESINHVKTAGVSMVVAVNKIDRSDANVDKITNDLLQHGVVPEKLGGDVMIVPVSAKTGENLDKLKSSILLLAEMLELRAPVEGRAQGVVIESKIERNCGVVATVIVQRGTLRKGNVVVAGDGSYGKVRNMFDDSDNSVEEALPSMPVRVLGLDKVPKAGDVFLVMPSEKHARDLLEHRAGINLSRGRDSGRNDSVFTGPLFSMDRPEGVNMILKADVAGSLEAISRSVAQIEHEEVKFNILHKDIGDVTKSDILLAEAASAVVLAFNVKVDAQARDLVRQKDVDIRHHRVIYDLIDDVKGVVCGKLKPIIREVQVGLLVVREVFSSGKGGTVIGCYVSEGAVSRGALVKIYRNDAVTCEGKVKVLRRFKDDVKEVGHGLECGVLVEGAKDVAVGDVIKVLEVVEHARVVE
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIM1B_ARATH
Sequence: MILRLKDQTLIKINSTRSYLSSLVFRRDSHSQARTKPDHDRRRRGYERDVRIEEKKEHDGLFLCKSKGQHLLTNTRILDSIVRSSDIRPTDTVLEIGPGTGNLTMKLLEAAQNVVAVELDKRMVEILRKRVSDHGFADKLTIIQKDVLKTDFPHFDLVVANIPYNISSPLVAKLVYGSNTFRSATLLLQKEFSRRLLANPGDSDFNRLAVNVKLVADVKFVMDVSKREFVPPPKVDSSVIRITPKEIIPDVNVQEWLAFTRTCFGKKNKTLGSMFRQKKKVMELQSLSAGRHGSNVEVMNQTGGDSDSDVEEDGKDDLLCLDTDASMFKERVIEILRTNGFEEKRPSKLSHRELLHLLSLFNQAGIFFHDITSLQMDLHE
What is the function of this protein?
N6-adenine methyltransferase which modifies the AA dinucleotide at the plant mitochondrial 18S rRNA nucleotides A1914 and A1915.  Not active as mitochondrial transcription factor.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase, mitochondrial, 18S mitochondrial rRNA (adenine(1914)-N(6)/adenine(1915)-N(6))-dimethyltransferase, Adenosine dimethyl transferase 1B, Dimethyladenosine transferase 1B.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ANMK_ACIAD
Sequence: MTAIYIGVMTGTSMDGVDFVAASFDPLHIHATLTLPFEPALRDELMALTLPGDNEIDRMGKADVGLAKLIGHGINMLIEQNHLDRHVIKAIGSHGQTIRHRPEHGFTLQIGDPHIITELTGIPVISDFRRRDMAAGGQGAPLVPAFHQAIFQHSTIHRVILNLGGIANVSLLPAGNPDGVYGFDTGPANILMDAWCERYTGHPYDENGNWAAYGQPIRALLERLQAHEFFSKKPPKSTGREDFNLDWLDDQLADWRNDELEYDELEDTPENVQATLLKLTTRAIKKAIYRSELDTGEVYVCGGGAYNSHLLEQLRWRLRKHHWSVQSTSVLGLSPTWVEATAFAWLAMRFMQQQSANLPSVTGAAGFRILGTITSV
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RUVA_BURCJ
Sequence: MIGRIAGILLEKNPPHLLVDCNGVGYEIDVPMSTFYNLPQTGERVVLLTQQIVREDAHLLYGFLTQQERTTFRELLKITGIGARMALAVLSGMSVQELAQAVTMQDAARLTRLPGIGKKTAERLLLELKGKLGADLGALAGAASPSDHATDILNALLALGYSEKEGLAAIKNVPAGTGVSEGIKLALKALSKA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RUVB_PORGI
Sequence: MTEEFDIRQERYRGNDGEREVENKLRPLTFDSFSGQDKVVENLSIFVAAARLRGEALDHTLLHGPPGLGKTTLSNIIANELGVGLKITSGPVLDKPGDLAGLLSSLESNDVLFIDEIHRLSPVVEEYLYSAMEDYRIDIMLDKGPSARSIQINLSPFTLVGATTRSGLLTAPLRARFGINLHLEYYDVHTITGIVERSARILEVSCSHDAAVEIAGRSRGTPRIANALLRRVRDFAQVKGSGAIDKPIACYALEALNIDRYGLDNVDHKLLATIIDKFAGGPVGLSTIATALGEDPGTIEEVYEPFLIKEGFLKRTPRGREVTELAYTHLGRNPRPHRPSLFD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: YBJL_SALNS
Sequence: MNINVADLLNGNYILLLFVVLALGLCLGKLRLGSVQLGNSIGVLVVSLLLGQQHFSINTDALNLGFMLFIFCVGVEAGPNFFSIFFRDGKNYLMLALVMVGSALLIALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHSGIASTQLSSALDNLSLGYALTYLIGLVSLIVGARYLPKLQHQDLQTSAQQIARERGLDTDANRKVYLPVIRAYRVGPELVAWTDGKNLRELGIYRQTGCYIERIRRNGILANPDGDAVLQMGDEIALVGYPDAHARLDPSFRNGKEVFDRDLLDMRIVTEEIVVKNHNAVGRRLAQLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKTIADRIGFISIHSQVTDLLAFCAFFIIGLMIGMITFQFSNFSFGIGNAAGLLFAGIMLGFLRANHPTFGYIPQGALNMVKEFGLMVFMAGVGLSAGSGISNGLGAVGGQMLIAGLVVSLVPVVICFLFGAYVLRMNRALLFGAMMGARTCAPAMEIISDTARSNIPALGYAGTYAIANVLLTLAGTLIVIIWPGLG
What are the official names of this protein?
Putative transport protein YbjL.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FMAD_DICNO
Sequence: MKSLQKGFTLIELMIVVAIIGILAAIAIPQYQNYIARSQVSRVMSETGQMRTAIETCVLDGKEAGECFIGWTGSNLLDGDFTAGTESTAAATGQAGITIKYPVAADDEGNIVATFGRNAAAAIKPQTLTWSRSKEGTWTCATTVEAKFQPTGCKDK
What is the function of this protein?
Major component of the type IV fimbriae that plays an essential role in twitching motility, natural transformation, and protease secretion.
What are the official names of this protein?
Type IV major fimbrial protein FimA, 340 antigen, Pilin, Serogroup D.
What is the protein family that this protein belongs to?
Belongs to the N-Me-Phe pilin family.
What are the subcellular locations of this protein?
Fimbrium. Membrane; Single-pass membrane protein.
Protein: ASSY_RAT
Sequence: MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSKEFVEEFIWPAVQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELTCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKSPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDVLEIEFKKGVPVKVTNVKDGTTHSTSLDLFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIDKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPIDATGFININSLRLKEYHRLQSKVTAK
What is the function of this protein?
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable).  Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable).  Indirectly, may be involved in the control of blood pressure (PubMed:19491403).
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PURA2_BURL3
Sequence: MPNVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGVVRGKRGVIGNGVALDPEALLAEIGRMAELGLSVTPDNLSIAENATLVLPIHRAIDQAQERLRREPIGTTLRGIGPAYEDKVGRRGLRVGDLAEPGRLAAKLDVLVDHHNAWFRGLGLDEYSRDAMLATLVDLAPRILPFVRPVWADLNDATDRGERILFEGSQAVMLDIDWGTYPFVTSSGTVASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELSDATGETLRARGQEFGVNTGRPRRCGWLDAAQLRQAVRISGIDSLALTKLDVLDGFESIELCVGYEFDGARVDHLPASLDAQSRAKPVYERFDGWRGTVKGVRERAALPRAAQDFIARVEAVAGAPVSMITTGAERDDTIVLRNPFDAAAGA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase 2, AMPSase 2, AdSS 2, IMP--aspartate ligase 2.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARCA2_ECOL6
Sequence: MMEKHYVGSEIGQLRSVMLHRPNLSLKRLTPSNCQELLFDDVLSVERAGEEHDIFANTLRQQGIEVLLLTDLLTQTLDIPEAKSWLLETQISDYRLGPTFATDVRTWLAEMSHRDLARHLSGGLTYSEIPASIKNMVVDTHDINDFIMKPLPNHLFTRDTSCWIYNGVSINPMAKPARQRETNNLRAIYRWHPQFAGGEFIKYFGDENINYDHATLEGGDVLVIGRGAVLIGMSERTTPQGIEFLAQALFKHRQAERVIAVELPKHRSCMHLDTVMTHIDIDTFSVYPEVVRPDVNCWTLTPDGHGGLKRTQESTLLHAIEKALGIDQVRLITTGGDAFEAEREQWNDANNVLTLRPGVVVGYERNIWTNEKYDKAGITVLPIPGDELGRGRGGARCMSCPLHRDGI
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_ACIC1
Sequence: MIDDTLLEAEEKMEKATNVARENFAAIRTGRANPALFSKITVEYYGTPTPLNQLASFTVADARLIVIHPYDKGSLRAIEKAIRDSDLGVNPTDDGSVIRVAIPPLTEERRRDYIKMARHEAEEARVAIRNIRRHAKDALDKLQKDGEVGEDDVRRAEKELDELTHKYVAHIDEMLKHKEAELLEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.