PharMolix/UniProtQA huggingface dataset:
Protein: T106B_MOUSE
Sequence: MGKSLSHLPLHSNKEDGYDGVTSTDNMRNGLVSSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIEVKYIGVKSAYVSYDAEKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITNIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLLSIKVHNIVLMMQVTVTTAYFGHSEQISQERYQYVDCGRNTTYQLAQSEYLNVLQPQQ
What is the function of this protein?
In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864, PubMed:32160553).  May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864).  May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity).  In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (PubMed:32160553).  It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is particularly important in the sorting of lysosomes in axons or in dendrites (Probable).  In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864).  Required for proper lysosomal acidification (PubMed:28728022).
What are the official names of this protein?
Transmembrane protein 106B.
What is the protein family that this protein belongs to?
Belongs to the TMEM106 family.
What are the subcellular locations of this protein?
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor.
Protein: SBT25_ARATH
Sequence: MDIGLRIFVVFVLLVAVTAEVYIVTMEGDPIISYKGGENGFEATAVESDEKIDTSSELVTVYARHLERKHDMILGMLFEEGSYKKLYSYKHLINGFAAHVSPEQAETLRRAPGVRSVDKDWKVRRLTTHTPEFLGLPTDVWPTGGGFDRAGEDIVIGFVDSGIYPHHPSFASHHRLPYGPLPHYKGKCEEDPHTKKSFCNRKIVGAQHFAEAAKAAGAFNPDIDYASPMDGDGHGSHTAAIAAGNNGIPLRMHGYEFGKASGMAPRARIAVYKALYRLFGGFVADVVAAIDQAVHDGVDILSLSVGPNSPPTTTKTTFLNPFDATLLGAVKAGVFVAQAAGNGGPFPKTLVSYSPWITTVAAAIDDRRYKNHLTLGNGKMLAGMGLSPPTRPHRLYTLVSANDVLLDSSVSKYNPSDCQRPEVFNKKLVEGNILLCGYSFNFVVGTASIKKVVATAKHLGAAGFVLVVENVSPGTKFDPVPSAIPGILITDVSKSMDLIDYYNASTSRDWTGRVKSFKAEGSIGDGLAPVLHKSAPQVALFSARGPNTKDFSFQDADLLKPDILAPGYLIWAAWCPNGTDEPNYVGEGFALISGTSMAAPHIAGIAALVKQKHPQWSPAAIKSALMTTSTVIDRAGRLLQAQQYSDTEAVTLVKATPFDYGSGHVNPSAALDPGLIFDAGYEDYLGFLCTTPGISAHEIRNYTNTACNYDMKHPSNFNAPSIAVSHLVGTQTVTRKVTNVAEVEETYTITARMQPSIAIEVNPPAMTLRPGATRTFSVTMTVRSVSGVYSFGEVKLKGSRGHKVRIPVVALGHRR
What are the official names of this protein?
Subtilisin-like protease SBT2.5, Subtilase subfamily 2 member 5, AtSBT2.5, Subtilisin-like serine protease 3, At-SLP3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
Protein: KMS1_ARATH
Sequence: MGSAGVASSSSDVAISALREKHEKEVENLTLTTQPLNTLKLFVEATIQYIKRSISYLLAHGGWFILITTLLVVSGGLLVTVDGPHGKHVEEVLEYVRYGLWWIALGVASSIGLGSGLHTFVLYLGPHIALFTLKATLCGRVDLKSAPYDTIQLKRVPSWLDKSCSEFGPPLMISAAGSRVPLTSILPQVQLEAILWGIGTALGELPPYFISRAASISGSTVDGMEELDGSSTEDSGFMATHLNRVKRWLLTHSQHLNFFTVLVLASVPNPLFDLAGIMCGQFGIPFWEFFLATLIGKAIIKTHIQTIFIICVCNNQLLDWMENELIWILSHVPGLASMLPGLTAKLHAMKEKYIDAPSPVPSHIKVKKWDFSFASIWNGIVWLMLLNFFVKIVTATAQRHLKKKQEKEMATLTHSD
What is the function of this protein?
Involved in the early secretory pathway.  Required for the correct export of secretory products from the endoplasmic reticulum (ER) and involved in the maintenance of ER integrity.
What are the official names of this protein?
Vacuole membrane protein KMS1, Protein KILLING ME SLOWLY 1.
What is the protein family that this protein belongs to?
Belongs to the VMP1 family.
Protein: DLX1A_DANRE
Sequence: MTMSTIPESLNSPVSGKSVFMEFGPPSQQMSPSSMTHGHYSMHCLHSSGHPQHDSAYSPAPSFPRSLPYPYVNSVGSHSSSPYLSTVQTYPNNSALAQTRLEDPAPESEKNTVVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLMKQGGGTIDTNALANGRGLSTGSPSVAPVWNTTATVKTSTPTSYIPSYTSWYPTAHQDTMQQPQLM
What are the official names of this protein?
Homeobox protein Dlx1a, DLX-1, Distal-less homeobox gene 1a.
What is the protein family that this protein belongs to?
Belongs to the distal-less homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NEP_I89A7
Sequence: MDSNTTTSFQDILQRMSKMQLESSSVDLNGMITQFERLKIYRDSLGESVMRMGDLHSLQNRNATWRDELSQKFEEIRWLIAECRNILTKTENSFEQITFLQALQLLLEVESEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: VNS3_AHSV6
Sequence: MNLAAIAKNYSMHNGESEAIVPYVPPPYNFASAPTFSQRTSQMESVSLGILNQAMSSTTGASGALKDEKAAFGAMAEALRDPEPIRQIKKQVGIRTLKNLKMELATMRRKKSALKIMIFISGCVTLATSMVGGLSIVDDEILRDYKNNDWLMKTIHGLNLLCTTVLLAAGKISDKIQEEISRTKRDIAKRESYVSAASMSWNGDTEMLLQGIKYGES
What is the function of this protein?
May play a role in the release of virions from infected cells.
What are the official names of this protein?
Non-structural protein NS3.
What is the protein family that this protein belongs to?
Belongs to the orbivirus NS3 family.
Protein: RN180_PONAB
Sequence: MKRSKELITKNHSQEETSILRCWKCRKCIASSGCFMEYFENQVIKDKDDSVDAQNICHVWHMNIESLPEWISCLIQKAQWTVGKLNCPFCGARLGGFNFVSTPKCSCGQLAAVHLSKSRTDYQPTQAGRLMRPSVKYLSHPRVQSGCDKEVLLTGGGSKNRNHRLLNMARNNNDPGRLTEALCLEVRPTYFEMKNEKLLSKASEPKYQLFVPQLVTGRCTTRAFHRKSHSLDLNISEKLTLLPTLYEIRGKTTAYSRLNETQPIDLSGLPLQSSKNSCSFQNPSSFDPGMLLQRFSVAPHETQTQRGGEFQCGLEAASVYSDHTNTNNLTFLMDLPSAGRSMPEASDQEEHLSPLDFLHSANFSLGSINQRLNKRERSKLKNLRRKQRRRERWLQKQGKYSGVGFLDHMTLNNEMSTDEDNEYAEEKDSYICAVCLDVYFNPYMCYPCRHIFCEPCLRTLAKDNPSSTPCPLCRTIISRVFFQTELNNATKTFFTKEYLKIKQSFQKSNSAKWPLPSCRKAFHLFGGFHRHAAPVTRRQFPHGAHRMDYLHFEDDSRGWWFDMDMVIIYIYSVNWVIGFIVFCFLCYFFFPF
What is the function of this protein?
E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF180, RING finger protein 180, RING-type E3 ubiquitin transferase RNF180.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope.
Protein: RL34_MYXXD
Sequence: MSKRTYQPSKVRRNRAHGFRKRNATKGGRDVLKRRRAKGRKRLVVSAPKK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: SURE_PELTS
Sequence: MRILISNDDGIQAEGINALRACLQEQNEIYIVAPDRERSATGHKITMHRPLRVKEWHYPEAKTVGWAVDGTPADCVKLGLEALLPAPPDLVISGINLGPNLGTDVLYSGTVSAAIEGIINGIPAIAVSLASYDYRDFSFSGKLIKELVSAFGNRLPDKTLLNINVPPGKPCGIKVTRLGNRRYINIFDKRTDPRGRVYYWMAGEPFDLDEDDPDTDVWAVKEGYVSITPVHFDLTDYKIMERLKKLLKTAKILNRELKD
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCPA_TRIVH
Sequence: MRLAASIAVALPVIGAASAQGFPPPVTGVTVVKSKYDENVKITYKENDICETTEGVRSFTGHVHLPPDNDYFGVYQNYSINTFFWFFEAREDPKNAPLSIWLNGGPGSSSMIGLFQENGPCWINDDSKSTTNNSFSWNNRVNMLYIDQPNQVGFSYDELTNITYSTINDTISVADFSSGVPAQNLSTLVGTGSSQKPWATANNTVNAARSIWHFAQVWFQEFPEHKPNNNKISIWTESYGGRYGPSFASYFQEQNEKIKNHTITKEGEMHILNLDTLGVINGCIDLMFQAESYAEFPYNNTYGITAYTKEKRDAIIRDIHRPDGCFDKLAKCREAAKEGDPHFYSNNATVNAICAEANSDCDKYLMEPFQEANLGYYDIAHPLQDPFPPPFFKGFLSQSSVLSDMGSPVNFSHYSQAVGKSFHGVGDYARPDVRGFTGDIAYLLESGVKVALVYGDRDYICNWLGGEQVSLGLNYTGTEAFRKAGYADVKVNSSYVGGLVRQHGNFSFTRVFEAGHEVPGYQPETSLKIFERIMFNKDIATGELDIAQKQDYGTTGTESTFQVKNEIPPSPEPTCYLLSADGTCTPEQLNAIENGTAVVENYIIKSPAASKGNPPPTTTSSPTASPTAGSAMLKAPVAMLAISALTVLAFYL
What is the function of this protein?
Extracellular serine carboxypeptidase that contributes to pathogenicity.
What are the official names of this protein?
Carboxypeptidase S1 homolog A, Serine carboxypeptidase A, SCPA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: TR11B_MOUSE
Sequence: MNKWLCCALLVLLDIIEWTTQETLPPKYLHYDPETGHQLLCDKCAPGTYLKQHCTVRRKTLCVPCPDHSYTDSWHTSDECVYCSPVCKELQSVKQECNRTHNRVCECEEGRYLEIEFCLKHRSCPPGSGVVQAGTPERNTVCKKCPDGFFSGETSSKAPCIKHTNCSTFGLLLIQKGNATHDNVCSGNREATQKCGIDVTLCEEAFFRFAVPTKIIPNWLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDLCESSVQRHLGHSNLTTEQLLALMESLPGKKISPEEIERTRKTCKSSEQLLKLLSLWRIKNGDQDTLKGLMYALKHLKTSHFPKTVTHSLRKTMRFLHSFTMYRLYQKLFLEMIGNQVQSVKISCL
What is the function of this protein?
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.  Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro.  Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B.  May also play a role in preventing arterial calcification.  May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis.  TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin.
What are the subcellular locations of this protein?
Secreted.
Protein: CHMJ_STRBI
Sequence: MHPLSIEGAWSQEPVIHSDHRGRSHEWFRGESFRQAFGHDFPVAQVNVAVSHRGALRGIHYTEIPPGQAKYSVCVRGAGLDVVVDVRIGSPTFGRWEIVPMDAERNTAVYLTAGLGRAFLSLTDDATLVYLCSSGYAPAREHSVNPLDPDLGIAWPDDIEPLLSDRDENAPTLATAERLGLLPTYQAWQEQQQAQR
What is the function of this protein?
Involved in the biosynthesis of dTDP-6-deoxy-D-allose, an intermediate in the biosynthesis of mycinose, which is one of the two unusual sugars attached to the 16-membered macrolactone ring of the aglycone antibiotic chalcomycin.  Catalyzes the conversion of dTDP-4-oxo-6-deoxyglucose to dTDP-4-oxo-6-deoxyallose, via a C-3 epimerization.
What are the official names of this protein?
dTDP-4-dehydro-6-deoxyglucose 3-epimerase, dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase, dTDP-4-keto-6-deoxyglucose epimerase, dTDP-4-oxo-6-deoxy-D-glucose epimerase.
What is the protein family that this protein belongs to?
Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
Protein: GPC5C_HUMAN
Sequence: MAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAVAGAGIVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTEWLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCGRYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVLFYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQKGQSMFVENKAFSMDEPVAAKRPVSPYSGYNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAEDMYSAQSHQAATPPKDGKNSQVFRNPYVWD
What is the function of this protein?
This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
What are the official names of this protein?
G-protein coupled receptor family C group 5 member C, Retinoic acid-induced gene 3 protein, RAIG-3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.
Protein: G6PD_HALVD
Sequence: MDQPVLLTGAGGRVGQAILGHIGDAYDWRLLDREPLSDEKIPDSVDSTEVYVADVTDETAVRNAMDGVHAVIHLAGDPRPEAPWDSVLRNNIDGTQQMFDAAVDVGVEKFAFASSNHAVGAYETTDRTPDMYRPHHEFRLDGTELPRPSNLYGVSKAAGETLGRYYHDHHDISVVNVRIGNLTQHHPPKEYERGQAMWLSYRDCGHLFECCIEADYDYEIVYGISDNDRKYYSIDRARAVLGYDPQDNSAEFTFEGEPLDEA
What is the function of this protein?
Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
What are the official names of this protein?
NAD-dependent glucose-6-phosphate dehydrogenase, Glc6PDH, Archaeal zwischenferment.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: MED21_CAEBR
Sequence: MADRMTQLQDMINEMASLMTNAIGVLQATAPPCEFDAISQDHEEEPNCAIFAASIAKSAKNIEILIDSFPIEAGNMEDEVEQKMIQNDAVQREKVGELKELVGESTQLVSAVQKKLSEISRVQMSSRPSE
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 21, Mediator complex subunit 21.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS3_METBF
Sequence: MAIERKFVNDGFVKASMDEYFAEQLNRAGYGGMELNRTPMGTQIVIYSEKPGMVIGKAGKVIRKLTRDVAARYNLENPQIDAQEVKKPELNAQMMASRLAASIERGWYFRKAGHNTLRAVMNAGALGCEVVISGKLTGARSRVEKFVDGYIKHSGNPVDEVVDEGFAVAIKKLGTLGCKVRIIQPGVVLPDSYTTTEPSEPVTEPVEKPAEKPAAKPAEKPVEAPKKESAAKPKTPAVAPEKPVETAEVAEPEEAEEEPQAEVAEDLEEAEVIQVEGSEELRRQVNGVWQHKHEGYDYWHPMARVHKEAKE
What is the function of this protein?
Binds the lower part of the 30S subunit head.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: AREA_ASPNG
Sequence: MSGLTLGGGGSGGVRPTQPAAFASLQDSADADRRSSTTTSNNPPPLPSDFSQLSDDFSFGSPISPPHSSNAPDSLLHDSLFPEWKVGTPRAGFDGPDEMQRKDPLATQIWKLYSRTKAQLPNQERMENLTWRMMAMSLKRKERERAQQSRSASARNSVSGPSGIAQLTSPPLIASRPTRQNPSLSTDLTSDPMNLERIFIVPFESPSDHPSPQLTKGEATSAAIPIKSRKDQVAESTPVPASFPHPPQDQRKNSEFGYVPRRVRKTSIDDRQFFNLQVPTRKRPAEASPQVPPVSNAMLAQDPDLSGGVPDYALDASSAFALHHNNHSSSHHNHTSPGMPFGLDTYGLGEDPILTSAGPYQTQFTFSPTESPMTSGNPFANLYAHTPVASSLNSTDFFSPPQSGYQSTASTPQPAYDGEHSMFFDMPSVDARTQRRVPNYVSHRTSNLSASLQPRYMFNQNQDQSHHTGNHSSSMHSPGYPIPQPQHVDPTQVLNPNDFSTGASHAAMFSFGADSDNEDDDGNQFSDRAGLTMPGDLDDGADMNGGMQWDAQFPGSFHSLPGFTAQHRKHVTIGPTDMMDTPSEWAQSGSLGRTHGSAASVSEVRNREQDPRRQKIARTTSTPNTAQLLRQSMNANTSHTSPNTPPESGLSSAVPSRPASPGGSKNGEQSSGPTTCTNCFTQTTPLWRRNPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRSSANSLAVGTSRASKKSARKNSVQQTTVTTPTSSRAQSGATSFGVRRPRAGAVRRAEPLVPIAAAPPKANPTTSSPGQSRGTSSVQMAPKRQRRLEKATDAEAGGDEASKSSTASGGRSKVVALAPAMPPAAANPANHSIAGGQGASQEWEWLTMSL
What is the function of this protein?
Major nitrogen regulatory protein.  Positively acting regulatory gene of nitrogen metabolite repression.
What are the official names of this protein?
Nitrogen regulatory protein areA.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECR_HUMAN
Sequence: MAPRPLLLLLLLLGGSAARPAPPRARRHSDGTFTSELSRLREGARLQRLLQGLVGKRSEQDAENSMAWTRLSAGLLCPSGSNMPILQAWMPLDGTWSPWLPPGPMVSEPAGAAAEGTLRPR
What is the function of this protein?
Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973).  Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells (PubMed:25332973).  Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (By similarity).  Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity).  Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity).  In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (Probable).  Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity).  Also able to stimulate lipolysis in white adipocytes (By similarity).  Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity).  Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity).
What are the official names of this protein?
Secretin.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: DRS7B_PONAB
Sequence: MVSLATRKSLPKVKAMDFITSTAILPLLFSCLGVFGLFRLLQWVRGKAYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKISIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLSVNAVTADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTLAPGLFFSLMASRARKERKSKNS
What is the function of this protein?
Putative oxidoreductase.
What are the official names of this protein?
Dehydrogenase/reductase SDR family member 7B, Short-chain dehydrogenase/reductase family 32C member 1, Protein SDR32C1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: OPGG_PSEPW
Sequence: MIVSPHKASRIPGNRLRKALMASAALVGLMSAGQLWAFNLDDVAAKAKDLAGQKYEAPKSNLPAVFRDMKFADYQKIRFLQEKAEWAKDKTPFKLSFYHQGMHFDTPVKINEVTATTVEEIKYDPSRFEFGDVPHDPETTKNLGYAGFRVLYPINKADKQDEIMTLLGASYFRVVGKGHVYGLSARGLAIDTALPSGEEFPRFTEFWVEKPKPADKHLVIYALLDSPRSTGAYKLILRPGNDTVVDVQSRVFLRDHVSRLGIAPLTSMYLFGPNQPSKVMNYRPALHDSEGLSIHAGNGEWLWRPLNNPKHLSVSNFSVENPRGFGLMQRHRDFKDYEDLDDNYQKRPSAWIEPKGDWGKGTVDLVEIPTADETNDNIVAFWSPETLPEPGKPFEYDYRMHWTIDESRFQAQELGSVTQTMRSTGDVKQSNLIRQPDGSVAFLVDFAGPALAALPEDAAVRSQISVGDNAEVVENNLRYNPETKGWRLTLRMKIKEANKATEMRAALVRDVPVEAAKPAEEAKHDKTAAKHGKAEKAAKAEQSANAEQPAADAASTNGTPATTEKVLTETWSYQLPADE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: FABV_BURCH
Sequence: MIIKPRVRGFICVTTHPVGCEANVKEQIDYVTSHGPIANGPKKVLVIGASTGYGLAARISAAFGSGADTLGVFFERAGSETKPGTAGWYNSAAFEKFAAEKGLYARSINGDAFSDKVKQVTIDTIKQDLGKVDLVVYSLAAPRRTHPKTGETISSTLKPVGKAVTFRGLDTDKEVIREVSLEPATQEEIDGTVAVMGGEDWQMWIDALDEAGVLADGAKTTAFTYLGEQITHDIYWNGSIGEAKKDLDKKVLSIRDKLAAHGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKETGTHEGCIEQVYGLLKDSLYGATPHVDEEGRLRADYKELDPQVQDKVVAMWDKVTNENLYEMTDFAGYKTEFLRLFGFEIAGVDYDADVNPDVKIPGIIDTTV
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: GSA_PYRAE
Sequence: MLFERAKSVFPGGVNSPARALKHLPSPLVAKAASGAYLYTDRGKLVDYCMAFGAIILGHAHPRVKKAVEEQLEKGWIYALLTEQEVEFAERIRRHMPSVEKMRIVNTGTEATMSAIRAARGYTKRDVIIKFEGNFHGSHDYVLVKAGSGAATWGIPTSAGIPQEVARLTVVVPYNDIDAFIKAVREVGDRLAAVIVEPVAGNYGLIIPDVEFLKALREETQRAGALLIFDEVITGFRVGLGGAQGLFGIRPDLTTLGKVVGGGFPIGIFGGRGEVMDLVAPSGPVYNAGTYNAHPVSIAAGLAVLKELETGEPYRIANEAAERLAKGVEDVAGRLGFDVVVKRMASMFQFYFKKGDVKTPQDVRESNEKMYLKLHEIALKHGVYLTPSQYEVNFTSAAHGREVVEETLAALEKSFQELQREIG
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB1_NITMU
Sequence: MRWSLSKPSDKPSGPATPGSSIIRDNGFEEDGRRSVLLTRLQDLVAWGRKNSVWPYNFGLSCCYVEMATSFTSKYDLARFGSEVIRASPRQADLIVISGTVFIKMAPVLQRLYDQMLEPRWVISMGSCANSGGMYDIYSVVQGVDRFLPVDVYVPGCPPRPDAFMQGLNLLQDAIGKEKRPLSWVIGPQGIERPAEESQRDLKRSGRMCATTLRSPDEVQK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 1, NADH dehydrogenase I subunit B 1, NDH-1 subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BRD9_DANRE
Sequence: MGKKHKKYRPEWRAVEGDYEDKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHEWERHKEKKKKKKKKSEKEKYADDDERRRRKEEKKKKREREQSETASTAPVEPFTLPKPVEVVVEEKKRKRDKFESESEADEFHPAVKVEVEQPADRPVRACRTQQENEATPHQQLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAAKKLLHTGFKMMSKQAAILGDDDIAPEEPVTEMMPIHTEYPKKSKKQPVKEPIISDMYELEGNACSLTDSTAEEHVLALVEHAADEARDRINRFMPNSKIGYLKKDTEGSLMYVVVNQDPEGEEEETHPVDLSSLANKLIPGLTSLGFKDDRRHKVTFLSSAYNTQTLQNNSIYPDLHPEEMDMLYSAYGDETGVQCALSLQEFVKGCGGFTKRLVDDLLDKMTAGDHSKAVVQIRQKRNLPIDEAKSSLCDMPGTDGGGMEAGSVLDFMSMKSYPDMSLDMLNTLGKCVKKEPEHEDGHQHFDDPTKLLQEFQDASVDRVGSRPSSNLSSLSNASERDQHHLGSSPHLGVGDQAEMVQDPYEFLQSPEPGSTANS
What is the function of this protein?
Plays a role in chromatin remodeling and regulation of transcription.  Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated.
What are the official names of this protein?
Bromodomain-containing protein 9.
Protein: RL28_BORA1
Sequence: MARVCQVTGKGPMVGNNVSHANNKTKRRFLPNLQSRRFWVESENRWVRLRVTAKAIRTIDKNGIDAVLADLRARGEAV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.