PharMolix/UniProtQA huggingface dataset:
Protein: ISPD_SHEDO
Sequence: MSMTHTTPLVPKNVAIVPAAGIGARMAAGMPKQYLTLGAQSILGHTLDALLSHPQIAQVIVALHPHDDMFLGLPQAKHSKLLTVIGGGERADSVLAALAVAPQDAWALVHDAARPCLTHSDIDKLLASTSEFPQGAILAMPVRDTMKRSDDTGVINHTVDRALLWHALTPQYFPVAELLTNLSAALNAGVVITDEASAMEWAGVFPGLVSGRADNIKVTHPDDLHLAGLFMAHLSAKPLVE
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: KATG_GEOSM
Sequence: MSTDSQCPVTGRANKHAARVGRMNRDWWPNQLNLKILHQHSPLSNPMGGNFNYSEEFKALDLAAVRNDIFELMTNSQDWWPADYGHYGPLFIRMAWHSAGTYRTGDGRGGARSGSQRFAPLNSWPDNANLDKARMLLWPIKQKYGKKISWADLLIFAGNCALESMGFKTFGFGGGREDIWEPGEDIYWGAEDTWLGDKRYSGERLLENPLAAVQMGLIYVNPEGPNGNPDPLAAAKDIRETFARMAMNDEETVALIAGGHTFGKCHGAGAATHVGPEPEGASIIEQGLGWKCSLGTGRGEHTITSGLEGAWTTNPVKWDNGFFDVLFSYDWALAKSPAGAHQWIPTDPAAKGTVPDAHNPAKRHAPMMLTTDLALKLDPIYGPISKRFHEQPDLFADAFARAWFKLTHRDMGPRACYLGPEVPAEDLIWQDPLPARNHELIDDQDIAELKGKIVTSGLSVSQLVSTAWASASTFRSSDRRGGANGARIRLAPQKDWEVNQPAQLKLVLETLEGIQKQFNSAQSGGKRVSIADLIVLGGCAAVELAARNAGHEIIVPFTPGRTDAAQEQTDVVAFAPLEPAADGFRNYLKTRYSVSAEELLVDRAQLLTLSAPEMTVLIGGMRVLDANADRSRHGVFTRRPGTLTNDFFVNLLDMGTTWNATSEAEDVFEGRDRVTGEMKWTGTRVDLIFGSNSLLRAQAEVYGCKDAQEKFVVDFIAAWSKVMNLDRFDIANS
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: CSRA_STRMK
Sequence: MLILTRRVGETLMIGDSVSVTVLGVKGNQVRIGITAPKDVAVHREEIYQRIQRGDEAGGTGSENSAE
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_METPB
Sequence: MHRYRTHTCGALRPSDVGQTVRLSGWCHRIRDHGGVLFIDLRDHYGLTQCVIDSDSPAFKAAETARSEWVIRIDGRVRTRPAGTENAELPTGSVEVYIDDLEVLGPAGELPLPVFGDQEYPEETRLKYRFLDLRREKLHANIMKRGAIIDSLRRRMREGGFFEFQTPILTASSPEGARDYLVPSRVHPGKFYALPQAPQQFKQLTMIAGFDRYFQIAPCFRDEDARADRSPGEFYQLDIEMSFVTQEDVFQAVEPVLRGVFEEFANGKRVTKEFPRITYADAMLKYGVDKPDLRNPLIIADVTDEFADDAVEFKAFKGVIKSGGVVRAIPATGAAGQPRSFFDKLNDWARSEGAPGLGYIVFEEEGGALTGKGPIAKFIPPEIQARIAQKAGAKAGDAVFFAAGTEAKAAALAGKARIRIGDELKLSDTDQFAFCWVVDFPMYEWNEEDKKIDFSHNPFSMPNYDRDAFLALGEEDAEKILGIKAFQYDIVCNGIELSSGAIRNHRPDVMEKAFAIAGYGRDVLEEKFGGMLNALRLGAPPHGGIAPGVDRIVMLLCEEPNIREVVLFPMNQRAEDLMMGAPAEATPKQLRELHIRLNLPEKKG
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_XYLFT
Sequence: MLMSRISYRRLDGILLLDKPAGISSNSALQVARRLLRAKKGGHTGSLDPLATGLLPLCFGEATKIAGLLLDSTKAYDADVLLGTTTTTDDAEGAVLLTRPVPTLDAEMVDALIPQLIGRIRQRAPIYSALKQGGEPLYAKARRGEVVNAPVREVEVHAIELLFLATPRLQLRVTCGSGTYIRSLVRDLGEILGCGAHINALRRRWVAPFQIPKMLTLDALEQALSAGRDPDSLLLPLVEGLAGFPALELDAQRLACFRLGQRLRDHSFQTGRVAVFSRDGIPAGLGEVDSEGLLVPQRLFNL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: METN2_STAA3
Sequence: MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEQGPVTQVFENPQHTVTKRFVKDDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PAX_I80A8
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFVSPKEAKRQLKKDLKSQEPCAGLPTKVSHRTSPALKTLEPMWMDSNRTAALRASFLKCQKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: OBG_MYCVP
Sequence: MTRFIDRVVIHARAGNGGNGCASVHREKFKPLGGPDGGNGGRGGSVVFVVDPQVHTLLDFHFHPHVVAPSGKQGAGSNRDGAAGTDLEVKVPDGTVVLDEHGQILADLVGEGTRFEAAAGGRGGLGNAALASRARKAPGFALLGEKGESRDLTLELKTVADVGLVGFPSAGKSSLVSTISAAKPKIADYPFTTLAPNLGVVSAGEHTYTVADVPGLIPGASQGRGLGLDFLRHIERCAVLVHVIDCATLEPGRDPISDIEALEAELAAYTPTLQGDSTLGDLAERPRAVVLNKIDVPEARELADFVREEIEAKFGWPVFEISTVAREGLRQLTFALWDMVAAYRAAQPAAVSRRPVIRPIPVDETAFSVVPDGQGGFIVKGTRPQRWVAQTNFDNDEAVGYLGDRLARLGVEDALLKLGARPGCAVTIGDMTFDWEPQTPAGVDVPLTGRGTDVRLEQTDRVGADERKAARKARRQSGDE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_PYRAB
Sequence: MIEVGEYKVKEGLYYTKEHEWAQVLEDGTVLVGITDYAQKELGDIAYVELPEVGKEVKKGEVLCEVESVKAVSEVYAPVSGEVIEVNEELSDSPEKINEDPYGAWIAKIKPNNLEEELKELMDAEKYAEFLKSL
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Probable glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: AMTB_ECOLI
Sequence: MKIATIKTGLASLAMLPGLVMAAPAVADKADNAFMMICTALVLFMTIPGIALFYGGLIRGKNVLSMLTQVTVTFALVCILWVVYGYSLAFGEGNNFFGNINWLMLKNIELTAVMGSIYQYIHVAFQGSFACITVGLIVGALAERIRFSAVLIFVVVWLTLSYIPIAHMVWGGGLLASHGALDFAGGTVVHINAAIAGLVGAYLIGKRVGFGKEAFKPHNLPMVFTGTAILYIGWFGFNAGSAGTANEIAALAFVNTVVATAAAILGWIFGEWALRGKPSLLGACSGAIAGLVGVTPACGYIGVGGALIIGVVAGLAGLWGVTMLKRLLRVDDPCDVFGVHGVCGIVGCIMTGIFAASSLGGVGFAEGVTMGHQLLVQLESIAITIVWSGVVAFIGYKLADLTVGLRVPEEQEREGLDVNSHGENAYNA
What is the function of this protein?
Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)) (PubMed:14668330, PubMed:15876187, PubMed:15563598, PubMed:15361618, PubMed:16910683, PubMed:30211659, PubMed:32662768).  Transport is electrogenic (PubMed:30211659, PubMed:32662768).  Following sequestration of NH(4)(+) at the periplasmic face, NH(4)(+) is deprotonated and neutral NH(3) is transported into the cytoplasm (PubMed:15876187, PubMed:16910683, PubMed:18362341, PubMed:19278252, PubMed:32662768).  Neutral NH(3) and charged H(+) are carried separately across the membrane on a unique two-lane pathway, before recombining to NH(4)(+) inside the cell (PubMed:32662768).  In vitro can also transport the larger analogs methylamine and methylammonium (PubMed:11847102, PubMed:14668330, PubMed:12023896, PubMed:15876187, PubMed:17998534, PubMed:18362341).  Also acts as a sensor of the extracellular ammonium concentration (PubMed:14668330).
What are the official names of this protein?
Ammonium transporter AmtB, Ammonia channel AmtB, Ammonium channel AmtB.
What is the protein family that this protein belongs to?
Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURI_BRUSU
Sequence: MKKAPAGSFPAKPTIAPERPILVFDSGIGGLTVLREARVVMPDRRFVYIADDAGFPYGNWEEEALKRRIIELFGEFIANYDPEIAVIACNTASTLVLEDLRRAYPSVPFVGTVPAIKPAAERTSSGLVSVLATPGTVKRAYTRDLIQSFASRCHVRLVGADGLAAIAEAHIRGESFDEALVMAQIAPCFIEKDGKRTDIVVLACTHYPFLVNVLRRLAPWPVDWLDPAEAIARRMKSLLPARSDDDEFHSQDDLAFFTSRKPDYAIRRLMQGFGLRF
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: RL16_FLAPJ
Sequence: MLQPKRTKYRKVQKGKMKGNSQRGHELSNGMFGIKSVHEDGMFLTSRQIEAARIAATRFMKREGQLWIKIFPDKPITKKPLEVRMGKGKGAVEYWAAVVKPGRIMFEVGGVPLSVAKEALRLAAQKLPCKTKFVVARDFEA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: SMKZ_MOUSE
Sequence: MYSDSEDESSELSTVLSMFEEKEFTRQYTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKVSEVEIMKMLSHPNIVSLLQVIETEQNIYLIMEVAQGTQLHNRVQEARCLKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNVKIVDFGLGARFMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMVTGIFPFVGSTLSEISKEVLQGRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLLSHPWLQEGEKTITFHSNGDTSFPDPDIMAAMKNIGFHVQDIRESLKHRKFDETMATYNLLRAEACQDDGNYVQTKLMNPGMPPFPSVTDSGAFSLPPRRRASEPSFKVLVSSTEEHQLRQTGGTNAPFPPKKTPTMGRSQKQKRAMTAPCICLLRNTYIDTEDSSFCTSSQAEKTSSDPEKSETSTSCPLTPRGWRKWKKRIVACIQTLCCCTLPQKKCPRSVHPQK
What is the function of this protein?
May play a role in sperm motility, especially in the regulation of flagellar function.
What are the official names of this protein?
Sperm motility kinase Z.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily.
Protein: RL22_CHLPN
Sequence: MFKATARYIRVQPRKARLAAGLMRNLSVQEAEEQLGFSQLKAGRCLKKVLNSAVANAELHENIKRENLSVTEVRVDAGPVYKRSKSKSRGGRSPILKRTSHLTVIVGEKER
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RK36_CYAPA
Sequence: MKVRASVRKMCEKCRTIRRKGRVMVICSNSKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, cyanelle.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: SYP_STAAE
Sequence: MKQSKVFIPTMRDVPSEAEAQSHRLLLKSGLIKQSTSGIYSYLPLATRVLNNITAIVRQEMERIDSVEILMPALQQAELWEESGRWGAYGPELMRLQDRHGRQFALGPTHEELVTSIVRNELKSYKQLPMTLFQIQSKFRDEKRPRFGLLRGREFIMKDAYSFHADEASLDQTYQDMYQAYSRIFERVGINARPVVADSGAIGGSHTHEFMALSAIGEDTIVYSKESDYAANIEKAEVVYEPNHKHTTVQPLEKIETPNVKTAQELADFLGRPVDEIVKTMIFKVDGEYIMVLVRGHHEINDIKLKSYFGTDNIELATQDEIVNLVGANPGSLGPVIDKEIKIYADNFVQDLNNLVVGANEDGYHLINVNVGRDFNVDEYGDFRFILEGEKLSDGSGVAHFAEGIEVGQVFKLGTKYSESMNATFLDNQGKAQSLIMGCYGIGISRTLSAIVEQNHDDNGIVWPKSVTPFDLHLISINPKKDDQRELADALYAEFNTKFDVLYDDRQERAGVKFNDADLIGLPLRIVVGKRASEGIVEVKERLTGDSEEVHIDDLMTVITNKYDNLK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSPC1_DICCH
Sequence: MNISKLPPLSPSVIRRILFYLLMLLFCQQLAMIFWRVGLPDNSPVASVQITPAQARQQPVTLNDFTLFGVSPEKNRSGALDASQMSNLPPSTLNLSLTGVMVGDDTARSIAIISKDNEQFSRGVNEEVPGYNAKIVSIRPDKVVLQYQGRYEVLGLYNQEENSADGVSGAQLNEQLQQRASTTMSDYVSFSPVMNDNKLHGYRLNPGPKSDSFYRVGLQDNDMAVALNGLDLRDEEQAKKAMERMADVHNFTLTVERDGQRQDIYMEFGGDE
What is the function of this protein?
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.  Required for the translocation of the multiple pectic enzymes.
What are the official names of this protein?
Type II secretion system protein C, T2SS protein C, General secretion pathway protein C, Pectic enzymes secretion protein OutC.
What is the protein family that this protein belongs to?
Belongs to the GSP C family.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: PPT1_YEAST
Sequence: MSTPTAADRAKALERKNEGNVFVKEKHFLKAIEKYTEAIDLDSTQSIYFSNRAFAHFKVDNFQSALNDCDEAIKLDPKNIKAYHRRALSCMALLEFKKARKDLNVLLKAKPNDPAATKALLTCDRFIREERFRKAIGGAENEAKISLCQTLNLSSFDANADLANYEGPKLEFEQLYDDKNAFKGAKIKNMSQEFISKMVNDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVELENNSTPDVKISVCGDTHGQFYDVLNLFRKFGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQEANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVVPGHGILQAGRNDDQNLIIETFEAVEHPDIKPMAYSNGGFGL
What is the function of this protein?
Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90 (HSC82 and HSP82).  Dephosphorylation positively regulates the Hsp90 chaperone machinery.
What are the official names of this protein?
Serine/threonine-protein phosphatase T, PPT.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CF047_HUMAN
Sequence: MFLRRLGGWLPRPWGRRKPMRPDPPYPEPRRVDSSSENSGSDWDSAPETMEDVGHPKTKDSGALRVSGAASEPSKEEPQVEQLGSKRMDSLKWDQPISSTQESGRLEAGGASPKLRWDHVDSGGTRRPGVSPEGGLSVPGPGAPLEKPGRREKLLGWLRGEPGAPSRYLGGPEECLQISTNLTLHLLELLASALLALCSRPLRAALDTLGLRGPLGLWLHGLLSFLAALHGLHAVLSLLTAHPLHFACLFGLLQALVLAVSLREPNGDEAATDWESEGLEREGEEQRGDPGKGL
What are the official names of this protein?
Uncharacterized protein C6orf47, Protein G4.
Protein: PAND_CYTH3
Sequence: MNIEVLKSKIHRVKVTQAELHYVGSITIDEALMEASNIIENEKVQIVNINNGERFETYVIKGEKNTGVICLNGPAARKVAVGDIVIVIAYASMDFEEAKKWKPTLIFPDANNRLI
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_BORAP
Sequence: MNNNVFHFPVLLDAICKLIEDLPVKSDLIYIDSTLGEGAHAKAILEKYDFLSLVGIERDSQILERAKQFLLIFKDRITYFNDWFDNFFANYPLNVKANFILVDLGISMFHYKDSKKGFSFLEDEPLDMRLCSSSCSISAAEIVNTFSKYDLESLIYNLSNEHYSRRISKAIVEYRKIKKIQTTKELQSIINKVYPFSKVKINPATKTFQALRIYVNDELARLKRSLPLWVENLAKDGILAIITFHSIEDRIVKDFFRSLSCDLYVKISKKPIIPSSDEIKKNKPSRSAKLRAVKKI
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_DESVV
Sequence: MLTFPRIDPVAITLGPLQFRWYGLMYLFGFLSGWWLGRRRAAQPGSRWTGEMVDDMVTYVILGVVLGGRIGYILFYDLAYYLSNPTQIFSIWNGGMSFHGGLLGVVFAMWLLGRRNGLGFMDVSDFVAPLIPPGLFFGRIGNFINGELWGKHTTLPWGMVFPDGGPFPRHPSQLYECALEGVILFLALWVFSSRKRPTGHVSGLFALLYGVFRFTVEFVREPDVQLGYLAFGWLTMGQVLCLPLIMLGLWLLRPGGDKGTKAA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YEAL_SALPC
Sequence: MFDVTLLILLGLAALGFISHNTTVAVSILVLIIVRVTPLNTFFPWIEKQGLTVGIIILTIGVMAPIASGTLPPSTLIHSFVNWKSLVAIAVGVFVSWLGGRGITLMGNQPQLVAGLLVGTVLGVALFRGVPVGPLIAAGLVSLIVGKQ
What are the official names of this protein?
UPF0756 membrane protein YeaL.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VIF_HV1MN
Sequence: MENRRQVMIVWQADRMRIRTWKSLVKHHMYISKKAKGRFYRHHYESTHPRISSEVHIPLGDARLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPDLADHLIHLHYFDCFSDSAIRKAILGHRVSPICEFQAGHNKVGPLQYLALTALITPKKIKPPLPSVKKLTEDRWNKPQKTKGHRGSHTINGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: HNMTA_XENLA
Sequence: MDSKLRSLLSDHSRYVESFRLFLQNSTEHQCMQHFIESKLPNIISSIGNDKPVIDVLGVGSGSGEIDLQMIAKIQARWPGVPINNQIVEPSAEQIFGYKERVAKAPNLENVTFSWHRQTSSEFESQVNEDKQMRKFDFIHMIQMLYYVKDVLGTLKFFKSCLAPSGKLLIILVSGNSGWATLWKKYGQRLPLNDLCLYITAGDIAEMLSSMGARFQSHELQSDMDITECFIEGDRDGELLLDFLTETCDFKRNAPADLRDQIICDLKSPGCSTTKDGKVIFNNNLSVIVVEAD
What is the function of this protein?
Inactivates histamine by N-methylation.  Plays an important role in degrading histamine and in regulating the airway response to histamine.
What are the official names of this protein?
Histamine N-methyltransferase A, HMT A.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCYP_BACAH
Sequence: MNTLLVGINVAVMLILVGVLYYMQRKHVSFNKRVFTALGIGIIFGLILQFIYEPTSKVIIESNTWFGLIGSGYVKLLQMIVMPLILVSIISAFTKLQLTKNLGKISGLIIGILILTTGIAAAVGIAASAGFDVSATGLQQGDAESARLKLVEERFTSIEKTTIPDKLLELLPTNPFLDLTGARPTSTISVVIFAAFIGIAFIGVKRKYPEQAELFKKMLDAVYAIVMRMVTLILRLTPYGVLALMAKTVAGSDINAILKLGNFVLASYVALIVMFVIHLLLIALSGLNPIQYLKKVFPVLTFAFTSRSSAGAMPLNIEAQKEKLGISEGIANFAASFGVSIGQNGCAGIYPAMLAMMVAPTVGIDPLQPQFILTLIAVVAISSFGVAGVGGGATFAALIVLSTMNLPIGIVALVISVEPLIDMGRTALNVSGSMTAGLISSKWLGELDQDTYNQDDTKTGEIAS
What is the function of this protein?
Mediates uptake of L-cystine, the oxidized form of L-cysteine.
What are the official names of this protein?
L-cystine uptake protein TcyP, Transporter of cystine TcyP.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DXS_MYCBO
Sequence: MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRSQDFATLRKKGGLSGYPSRAESEHDWVESSHASAALSYADGLAKAFELTGHRNRHVVAVVGDGALTGGMCWEALNNIAASRRPVIIVVNDNGRSYAPTIGGVADHLATLRLQPAYEQALETGRDLVRAVPLVGGLWFRFLHSVKAGIKDSLSPQLLFTDLGLKYVGPVDGHDERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEADQAEQMHSTVPIDPATGQATKVAGPGWTATFSDALIGYAQKRRDIVAITAAMPGPTGLTAFGQRFPDRLFDVGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLNRAFDQIMMDVALHKLPVTMVLDRAGITGSDGASHNGMWDLSMLGIVPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVGEDISALERRGGVDVLAAPADGLNHDVLLVAIGAFAPMALAVAKRLHNQGIGVTVIDPRWVLPVSDGVRELAVQHKLLVTLEDNGVNGGAGSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSEVLADLGLTDQDVARRITGWVAALGTGVCASDAIPEHLD
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.