PharMolix/UniProtQA huggingface dataset:
Protein: UTP25_CHAGB
Sequence: MAPGGRAGFRGGSSRGGPSRGGTRGRGSSRGRGRGRGRAVAQQPRGARFDDKRLASKDESESEAGSESPSDDESDAMEVDSNEEDEEETQSAQPYLSLMRSLVESAPKAKRRKLDHASAERQGPESTKPEAAPEATDGEEDGDEDGEERDVDFVEEPEEDPTNAAPEDLFDEDDDLDVSDPFEVHFADPKEEVLRPRLEAIQGNKWRMERIAANSTRVFFNTPDAGDAAAKPLPAPISGISDLKLKKRLQEAMAPKHAKFDQVEQTIAPLLFNYQDMLYCNRTVAGSQGIRRMASLHALNHVFKADGNEDLELRDQGFTRPKVLMLLPTRQSCVKMVDMIVSICEPDQQENRKRFEDGYIDKQSKFSDDKPDDFKDLFSGSDDDMFRLGMKFTRKTIKYFSQFYNSDIIFASPLGLRMAIGSEEEKKLDFDFLSSIELVIVDQADALLMQNWEHVEFIFEHLNVQPKDAHGCDFSRVRSWYLDDQAKHFRQTVIFSAFNTPELVELLRTHCHNWAGKARLQQESAGTIQHLPVKARQTFSRFEAGSIAADPDARFAYFTKAIVPMLARHRGRDAAGTLVFIPSYLDFVRVRNYFANNPAVENVSFGTISEYADVPEASRARSHFLNGRHKVLLYTERAHHFRRYQIKGVKRVVMYALPDNPLFYQEIAGGYLQKSEQSLLVEHGQGVVRVMFSKYDVMKLERIVGTSRVGKMIHDQGDTFDFV
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RS11_RHOPB
Sequence: MGKEATRVRRRERKNIASGIAHVNSSFNNTTITITDAQGNTIAWSSAGTMGFKGSRKSTPYAAQVAAEDVSKKAQEHGMRTLEVEVAGPGSGRESALRALQAAGFTVTSIRDVTTIPHNGCRPRKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RSXB_ECODH
Sequence: MNAIWIAVAAVSLLGLAFGAILGYASRRFAVEDDPVVEKIDEILPQSQCGQCGYPGCRPYAEAISCNGEKINRCAPGGEAVMLKIAELLNVEPQPLDGEAQEITPARMVAVIDENNCIGCTKCIQACPVDAIVGATRAMHTVMSDLCTGCNLCVDPCPTHCISLQPVAETPDSWKWDLNTIPVRIIPVEHHA
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rsx electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: SFMH_ECOLI
Sequence: MAMACLCLANISWATVCANSTGVAEDEHYDLSNIFNSTNNQPGQIVVLPEKSGWVGVSAICPPGTLVNYTYRSYVTNFIVQETIDNYKYMQLHDYLLGAMSLVDSVMDIQFPPQNYIRMGTDPNVSQNLPFGVMDSRLIFRLKVIRPFINMVEIPRQVMFTVYVTSTPYDPLVTPVYTISFGGRVEVPQNCELNAGQIVEFDFGDIGASLFSAAGPGNRPAGVMPQTKSIAVKCTNVAAQAYLTMRLEASAVSGQAMVSDNQDLGFIVADQNDTPITPNDLNSVIPFRLDAAAAANVTLRAWPISITGQKPTEGPFSALGYLRVDYQ
What is the function of this protein?
Part of the sfmACDHF fimbrial operon.  Could contribute to adhesion to various surfaces in specific environmental niches.  Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
What are the official names of this protein?
Uncharacterized fimbrial-like protein SfmH.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: RL14_METPB
Sequence: MIQMQTNLDVADNSGARRVMCIKVLGGSKRKYAGVGDIIVVSVKEAIPRGRVKKGDVMKAVVVRTAKDVKRADGSVIRFDKNAAVLINNQKEPVGTRIFGPVPRELRARNHMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: EFTS_LEPBJ
Sequence: MAAVTTDLIRELRERTSAGMMDCKKALEENNADIEKAITWLREKGIAKAAKKAGRETKEGRIVSYIHGNGKIGVLLELNSETDFVSKNEEFEALGKEICMQIAAMNPLYLNEESIPAADLEREKGIMKSQLEAEGKKAEQIEKILPGKIKKYVSEVCLVNQAFFKDDSKTIDDLVKEAIAKFGENITIAHFVRFQVGGL
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBA_BRANA
Sequence: MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYAGFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEAPSING
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL24B_YEAST
Sequence: MKVEVDSFSGAKIYPGRGTLFVRGDSKIFRFQNSKSASLFKQRKNPRRIAWTVLFRKHHKKGITEEVAKKRSRKTVKAQRPITGASLDLIKERRSLKPEVRKANREEKLKANKEKKRAEKAARKAEKAKSAGVQGSKVSKQQAKGAFQKVAATSR
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L24-B, L30, Large ribosomal subunit protein eL24-B, RP29, YL21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADH_CUPNH
Sequence: MTAMMKAAVFVEPGRIELADKPIPDIGPNDALVRITTTTICGTDVHILKGEYPVAKGLTVGHEPVGIIEKLGSAVTGYREGQRVIAGAICPNFNSYAAQDGVASQDGSYLMASGQCGCHGYKATAGWRFGNMIDGTQAEYVLVPDAQANLTPIPDGLTDEQVLMCPDIMSTGFKGAENANIRIGDTVAVFAQGPIGLCATAGARLCGATTIIAIDGNDHRLEIARKMGADVVLNFRNCDVVDEVMKLTGGRGVDASIEALGTQATFEQSLRVLKPGGTLSSLGVYSSDLTIPLSAFAAGLGDHKINTALCPGGKERMRRLINVIESGRVDLGALVTHQYRLDDIVAAYDLFANQRDGVLKIAIKPH
What is the function of this protein?
Multifunctional alcohol dehydrogenase exhibiting NAD(+)-dependent dehydrogenase activities for 2,3-butanediol, ethanol and acetaldehyde, and reductase activities for acetoin (NADH-dependent), and diacetyl and acetaldehyde (independently of whether NADH or NADPH is the reductant).  The rate of oxidation of 2,3-butanediol is much higher than for the oxidation of ethanol.  Has acetaldehyde dehydrogenase activity leading to acetate formation.  May function in the release of excess reducing power in the absence of exogenous hydrogen acceptors such as oxygen.
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: RL22B_YEAST
Sequence: MAPNTSRKQKVIKTLTVDVSSPTENGVFDPASYSKYLIDHIKVDGAVGNLGNAIEVTEDGSIVTVVSSAKFSGKYLKYLTKKYLKKNQLRDWIRFVSIRQNQYKLVFYQVTPEDADEEEDDE
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L22-B, L1c, Large ribosomal subunit protein eL22-B, RP4, YL31.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL22 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_STAES
Sequence: MASLKEIDSRIKSTSKMKQITKAMNMVSSSKLRRAEKNTKSFRPYMEKMQDAITAVAGSNSTSNHPMLKSRDIKRSGYLVITSDKGLAGAYSTNVLKSLVNDINSKHNDSSEYSLIVLGQQGVDFFKHRGYEIESSLVEVPDQPSFKSIQSIAKHAIDLFSEENIDELTIYYSHYVSVLENKPATKQVLPLSQEDSGQGHGQMSSYEFEPDKESILSVILPQYVESLIYGTILDAKASEHASRMTAMRNASDNATELIDDLSLEYNRARQAAITQQITEIVGGSSALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: REP_BCTVC
Sequence: MPPTKRFRIQAKNIFLTYPQCSLSKEEALEQIQGIQLSSNKKYIKIARELHEDGQPHLHVLLQLEGKVQITNIRLFDLVSPTRSAHFHPNIQGAKSSSDVKSYVDKDGDTIEWGEFQIDGRSARGGQQTANDSYAKALNATSLEQALQILKEEQPKDYFLQHHNLLNNAQKIFQRAPDPWTPLFPLSSFTNVPEEMQEWADAYFGVDAAARPLRYNSIIVEGDSRTGKTMWARSLGAHNYITGHLDFSLRTYYDEVEYNVIDDVDPTYLKMKHWKHLIGAQKEWQTNLKYGKPRVIKGGIPCIILCNPGPESSYQQFLEKPENEALKSWTLHNSTFCKLQGPLFNNQAAASSQGDSTL
What is the function of this protein?
Essential for the replication of viral ssDNA.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific region at the genome origin of replication.  It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities (By similarity).
What are the official names of this protein?
Replication-associated protein, Rep, 40.8 kDa protein, Protein C1.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: DF171_ARATH
Sequence: MAKTASSLVLPIIFLVMFALVEQNMGCMAVLGSCGVITDCSGECISRFGPQARGYCDRDGGSGTCVCVYPCPADKPHM
What are the official names of this protein?
Defensin-like protein 171, Low-molecular-weight cysteine-rich protein 61, Protein LCR61.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: LYSZ_SULIK
Sequence: MIVVKIGGRVVKNSLDKVILDIANINDKVILVHGGGDIVTDYTKRLGIEPVFVTSPEGIRSRYTTKEELEVYIMAMSLINKTITSKLCSLGKNAIGITGVDGGLLLAERKKRIIVIDERGKKRIIEGGYTGKVKEVRSEVINHLMKLFDIIVVSPLALDVEESTPLNIDGDQAAFAISKAVKVNVLVILSDVEGVLVEGKVVDRLTPEEAKELSKKIGPGMNRKLLMAAESVENGVNKVIIGSGVKDRPVSSALELNGTVIVNG
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.  Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
What are the official names of this protein?
[LysW]-aminoadipate/[LysW]-glutamate kinase.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. LysZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_SHELP
Sequence: MATLESKLEQMLIAPVEALGHSLWGLEYVQAGKHSVLRVYIDNENGIFIDDCADVSRQISAVLDVEDPISTEYTLEVSSPGVDRPLFTAEQYARYLGETVKVQLTMPVAGSRNLKGTVAGVEGQMLTLTVDGNELIIALDNIRKGNLIAKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPF_BORPA
Sequence: MNIPFRVGQGFDVHALVEGRPLIIGGVTIAHTHGLLGHSDADVLLHAVTDALLGGAGLGDIGRHFPDTDPAYRGADSRVLLRAAFDKVRAAGWAPVNVDATIHAQAPKIGPHAAAMVANIAADLALDAGAVNIKAKTNEGLGYLGRKEGIAANVVVLLARAG
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: MMAC_DANRE
Sequence: MAISSERVEELLRTFRESLKAKGFEIYPFKVGWYNAVLTAAHHLQYPADTLAVLVISTPAMFECAFLPFLQSQSCESLRDPIDQCTAHTLSACISLCFANQFVDVSYDYEMLPSRKPKFLAQTAAHVSGAAYYYQTSDIHNPPWGEKKMFGVCVHPQLGGWFAIRALLVFRDVQAGAGFQQRDPADCVCTQEERIRLLESFNLRWRDWSYRDIVPAEDRYSDQQKQYFITPPGQRRALLRQWGYLTDTQS
What is the function of this protein?
Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate.  Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle.  Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol.  The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.  Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether.  The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors.  Cysteine and homocysteine cannot substitute for glutathione in this reaction.
What are the official names of this protein?
Cyanocobalamin reductase / alkylcobalamin dealkylase, Alkylcobalamin:glutathione S-alkyltransferase, CblC, Cyanocobalamin reductase (cyanide-eliminating), Methylmalonic aciduria and homocystinuria type C protein, MMACHC.
What is the protein family that this protein belongs to?
Belongs to the MMACHC family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: DGR1_ARATH
Sequence: MMYQEAALLLALLFISSNVVLSAPVRDGLLPNGNFELGPKPSQMKGSVVKERTAVPNWNIIGFVEFIKSGQKQDDMVLVVPQGSSAVRLGNEASISQKISVLPGRLYSITFSAARTCAQDERLNISVTHESGVIPIQTMYGSDGWDSYSWAFKAGGPEIEIRFHNPGVEEHPACGPLIDAVAIKALFPPRFSGYNLIKNGNFEEGPYVFPTAKWGVLIPPFIEDDNSPLPGWMIESLKAVKYVDKAHFAVPEGHRAIELVGGKESAISQIVRTSLNKFYALTFNVGDARDGCEGPMIVEAFAGQGKVMVDYASKGKGGFRRGRLVFKAVSARTRVTFLSTFYHMKSDHSGSLCGPVIDDVRLVAVGKLRG
What are the official names of this protein?
Protein DUF642 L-GALACTONO-1,4-LACTONE-RESPONSIVE GENE 1, DUF642 L-GalL-RESPONSIVE GENE 1.
Protein: ENV_HV1JR
Sequence: MRVKGIRKNYQHLWKGGILLLGTLMICSAVEKLWVTVYYGVPVWKETTTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLENVTEDFNMWKNNMVEQMQEDVINLWDQSLKPCVKLTPLCVTLNCKDVNATNTTSSSEGMMERGEIKNCSFNITKSIRDKVQKEYALFYKLDVVPIDNKNNTKYRLISCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGKGQCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEKVVIRSDNFTDNAKTIIVQLNESVKINCTRPSNNTRKSIHIGPGRAFYTTGEIIGDIRQAHCNISRAQWNNTLKQIVEKLREQFNNKTIVFTHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNDTEKSSGTEGNDTIILPCRIKQIINMWQEVGKAMYAPPIKGQIRCSSNITGLLLTRDGGKNESEIEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGARSMTLTVQARQLLSGIVQQQNNLLRAIEAQQHMLQLTVWGIKQLQARVLAVERYLKDQQLMGIWGCSGKLICTTAVPWNTSWSNKSLDSIWNNMTWMEWEKEIENYTNTIYTLIEESQIQQEKNEQELLELDKWASLWNWFGITKWLWYIKIFIMIVGGLIGLRIVFSVLSIVNRVRQGYSPLSFQTLLPATRGPDRPEGIEEEGGERDRDRSGQLVNGFLALIWVDLRSLFLFSYHRLRDLLLTVTRIVELLGRRGWEILKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRIIEVVQRVYRAILHIPTRIRQGLERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: MIP_COXBU
Sequence: MKRLILPFLSVGLLLGTTAHAATPLKTEQDKLSYSMGVMTGKAFRKHDIKIDPQTFSMGLSDAYLGKETQMTEAEMRQTLQQFEKQSLQKMQHKMKQTAQQNAEKSRAFLTANKNKPGVKTLANGLQYKVLQAGQGQSPTLNDEVTVNYEGRLINGTVFDSSYKRGQPATFPLKSVIKGWQEALTRMKPGAIWEIYVPPQLAYGEQGAPGVIGPNEALIFKVNLISVKKK
What is the function of this protein?
May be an essential virulence factor associated with macrophage infectivity.  Exhibits PPIase activity.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase Mip, PPIase, Macrophage infectivity potentiator, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Secreted.
Protein: EFP_VIBVY
Sequence: MATVSTNEFKGGLKLMIDSEPCVILENEYVKPGKGQAFNRVKIRKLLSGKVLEKTFKSGDTCEVADVMDIDLDYLYSDGEFYHFMNNETFEQIAADAKAVGENVKWLVENNTCMLTLWNGNPIAVTPPNFVELEVIETDPGLKGDTQGTGGKPATLSTGAVVRVPLFIQIGEVIKVDTRSSEYVGRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCSA_SALTI
Sequence: MSTIIMDLCSYTRLGLSGYLVSRGVKKREINDIETVDELAIACGAHQPSVVFINEDCFIHTPSDSQQIKQIINQHPDTLFIVFMAIANVHFDEYLLVRKNLLISSKSIKPDSLDTLLGDILKKESGISGTINLPTLSLSRTESSMLRMWMEGQGTIQISDRMNIKAKTVSSHKGNIKRKIKTHNKQVIYHVVRLTDNVTNGIFANMR
What is the function of this protein?
Component of the Rcs signaling system, which controls transcription of numerous genes.  Binds, with RcsB, to the RcsAB box to regulate expression of genes.
What are the official names of this protein?
Transcriptional regulatory protein RcsA.
What is the protein family that this protein belongs to?
Belongs to the RcsA family.
Protein: LOLD_LEGPL
Sequence: MNDIILTSQKLYKSYHDGTSTVEVLKGVDLAITKGDRIAIIGPSGSGKSTLLHLLGGLDKPTSGLITLGNVNWQKINEKQRCQLRNQQLGFVYQFHHLLPEFTALENVMMPLLLAGMAVKDAEEKVINMLEQVGLKPRLTHKPAQLSGGERQRVAIARALVHQPHCVLADEPTGNLDEATASKVFDLMLELNKKMNTALVIVTHDQRIAERMDRVLVLHEGSLYARE
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PPY_LOPAM
Sequence: YPPKPETPGSNASPEDWASYQAAVRHYVNLITRQRYGXXSSPEEAVAWLLFKADPSQDIEPRLDDDNAW
What are the official names of this protein?
Pancreatic propolypeptide YG, APY.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: TINY_ARATH
Sequence: MIASESTKSWEASAVRQENEEEKKKPVKDSGKHPVYRGVRKRNWGKWVSEIREPRKKSRIWLGTFPSPEMAARAHDVAALSIKGASAILNFPDLAGSFPRPSSLSPRDIQVAALKAAHMETSQSFSSSSSLTFSSSQSSSSLESLVSSSATGSEELGEIVELPSLGSSYDGLTQLGNEFIFSDSADLWPYPPQWSEGDYQMIPASLSQDWDLQGLYNY
What is the function of this protein?
Putative transcriptional activator.
What are the official names of this protein?
Ethylene-responsive transcription factor TINY.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.