PharMolix/UniProtQA huggingface dataset:
Protein: LMBL3_HUMAN
Sequence: MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATATTTWMVPTAQEAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGMPFRLKDPVKVEGLQFCENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEEDNEEEDPKCSRKKKPKLSLKADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPPKGKKAWCWASYLEEEKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCEASSPHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPLSPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDRLSGEMPPASPSFPRNKRTDANESSSSPEIRDQHADDVKEDFEERTESEMRTSHEARGAREEPTVQQAQRRSAVFLSFKSPIPCLPLRWEQQSKLLPTVAGIPASKVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
What is the function of this protein?
Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483).  It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483).  Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1.  It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:30442713, PubMed:29691401).  Required for normal maturation of myeloid progenitor cells (By similarity).
What are the official names of this protein?
Lethal(3)malignant brain tumor-like protein 3, H-l(3)mbt-like protein 3, L(3)mbt-like protein 3, L3mbt-like 3, MBT-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: UREF_BORBR
Sequence: MHLSSPALPIGGFSYSQGLEAAIELGLVHDEASTLAWIESQLVTVMARAEAPLWCLLFEAWRAGDDAAAHGWNQWFHASRETRELRQETEQMGRSLARLAQELGWGTAATRAAVAALRPATLPAVHACACAMWALPREAGLGAYVFSWLENQVAAAIKGVPLGQMAGQRMLERLRAGLPAVLADARARAGATPPRLDTFAPQYAMVSARHETQFSRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOC_NEIG2
Sequence: MASIQNLYETVVGVLGDQAGKVISALGEITVECLPEHYISVMTALHDHEDLHFELLVDLCGVDYSTYKNEAWQGKRFAVVSQLLSVKNNQRIRVRVWVSDDDFPVVESVADIYNSADWYEREAFDLYGIMFNNHPDLRRILTDYGFVGHPFRKDFPISGYVEMRYDEEQKRVIYQPVTIEPREITPRIVREENYGGQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS11_CHRSD
Sequence: MANPRSNRKKVKKQVVDAVAHIHASFNNTIVTITDRQGNALSWATAGGSGFRGSRKSTPFAAQVASERAATAAAEYGVKNVDVLVKGPGPGRESAVRALNAAGFRVQSITDATPVPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: D2HDH_ORYSI
Sequence: MARRAAAGLLRRHLGPLAAGETLQARGMYPKQYGAANHAFSRFYSIQGQQRSLYGFRTNVETDDTQQSARMNFEVQKRSFSSAAAHVQRNPAYSVLNSDDVSYFKSILGDSGVVQDEDRVSVANMDWMGKYKGSSQLLLLPKSTAEVSKILSYCNSRRLAVVPQGGNTGLVGGSVPVYDEVIISLGGMDKIITFDNVNGILTCEAGCVLENLSSYVENKGFIMPLDLGAKGSCHIGGNISTNAGGLRFIRYGSLHGSVLGLEVVLADGTVLDMLTTLRKDNTGYDLKHLFIGSEGSLGIVTKIAILTPAKLPSTNVAFLSCNDYISCQKLLLAARRSLGEILSAFEFMDRHCINLAMKYLEGVHNPLPVSPYNFYVLIETTGSDESYDKAKLEAFLLRSMEDGLVADGVIAQDISQASNFWRIREGISEASVKVGAVYKYDLSIPVEKLYDIVEEMRSRVGDMGQVLGYGHLGDGNLHLNILSTKYSDKMLAQIEPFVYEWTSKQRGSISAEHGLGLMKADKIHYSKSSEAVQLMTSIKKLLDPNSILNPYKVLPQSVL
What is the function of this protein?
Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate.
What are the official names of this protein?
Probable D-2-hydroxyglutarate dehydrogenase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DB124_PANTR
Sequence: MTQLLLFLVALLVLGHVPSGRSEFKRCWKGQGACRTYCTRQETYMHLCPDASLCCLSYALKPPPVPKHEYE
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 124, Defensin, beta 124.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYAY_BUCAI
Sequence: MKKKLNTKKENNNFYILVNDLFLKIEDNLNLYENEIDIDYEIQDYVMTITFSNKTLIIINKQEPLQQIWLATMQNGYHFDYKNNQWICNRSNKNFWEIFENACSIQSNKDLIFCKK
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: SYT_FRAP2
Sequence: MINIKFPDGSIREFESGVNSLQIAKSISPSLAKITVGAYIDNKLSDAKDVINHDCELRLITTKDTEGLEILRHSCAHLLANAVKELYPNTEVTIGPVIDNGFYYDFSFKETIGEADLANIEKRMKEIAKKGSSISYKVVSKEDAIAFFKAQGENYKVDIIESIPADQQIKIYTQGDFSDLCRGPHVPSTAAIKAFKLTKLAGAYWRGDSNNEMLTRIYGTCWATKEDLDQYLHMLEEAEKRDHRKIGKALDLFHFQEDSPGIAFWHDNGVRIWREVEDYMRASNKKYGCGEIRTPLIADFSLWEKSGHASKYAENMFATKSENRDFAIRPMNCPTCVQVYNTKLHSYRDLPIRMAEFGIVHRNEPSGSLHGLMRVRSFTQDDGHIFCAPEQVEEEVILMVKQCFEVYKDFGFNDFTVKIALRPENRIGNDETWDKSEQMLKNALDANNVAYELLPGEGAFYGPKIEFHLKDAIGRSWQCGTIQLDFSMPDRLGATYIDKNGNKQVPVMLHRAIVGSLERFIGMLIEHYAGNMPLWLTPVQVAVMGISNHQDEYCQKVFETLEKNGIRAKLDLRNEKIGFKIREHTLLRVPYLVILGKSEQEQEIVTVRKHNGEDLGQMSIGDFCAFLNEQIEAKK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MID51_XENTR
Sequence: MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTSPTRLSHSGKRSWEEPNWMGSPRLLNRDMKTGLSRSLQTLPTDSSTFDTDTFCPPRPKPVARKGQVDLKKSRLRMSLQEKLLTYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPDMPLRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNVPGFFLVRRENPEYFPRGSSYWDRCVVGGYLSPKTVADTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTLEVQYERDKHLFIDFLPSVTLGDTVLVAKPHRLAQYDNLWRLSLRPAETARLRALDQADSGCRSLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDMLADRFLQALRGLISYLEAGVLPSALNPKVNLFAELTPEEIDELGYTLYCSLSEPEVLLQT
What is the function of this protein?
Mitochondrial outer membrane protein which regulates mitochondrial fission.  Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins.  Regulates DNM1L GTPase activity and DNM1L oligomerization (By similarity).
What are the official names of this protein?
Mitochondrial dynamics protein MID51, Mitochondrial dynamics protein of 51 kDa homolog, Mitochondrial elongation factor 1, Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like.
What is the protein family that this protein belongs to?
Belongs to the MID49/MID51 family.
Protein: RRAA_IDILO
Sequence: MEYNTSELCDLYPDMVDVVEPMFESYGGRSSFGGSLVIIKCHEDKGLIEETIAADGGGKILLIDGGGSSRRALVDAAIAEQAMDNDWEGIVCYGAVREVDALEELDIGILGVASIPVGAISEGVGELNVPVNFGGVTFLPEDHLYIDTTGVILSPEPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VEXIN_HUMAN
Sequence: MMHQIYSCSDENIEVFTTVIPSKVSSPARRRAKSSQHLLTKNVVIESDLYTHQPLELLPHRGDRRDPGDRRRFGRLQTARPPTAHPAKASARPVGISEPKTSNLCGNRAYGKSLIPPVPRISVKTSASASLEATAMGTEKGAVLMRGSRHLKKMTEEYPALPQGAEASLPLTGSASCGVPGILRKMWTRHKKKSEYVGATNSAFEAD
What is the function of this protein?
Required for neurogenesis in the neural plate and retina.  Strongly cooperates with neural bHLH factors to promote neurogenesis.
What are the official names of this protein?
Vexin.
What is the protein family that this protein belongs to?
Belongs to the vexin family.
What are the subcellular locations of this protein?
Cell membrane. Nucleus. Note=Nuclear localization is essential for its function in neurogenesis.
Protein: RPF1_DANRE
Sequence: MKAVKAPVEEMDQAECEVKEEKSASGPCFPPTFSVSEIKNKQRRHTMFLKLKEEKRKKRMELKKKKKKERKALDDKAPPKEVPKTIENQRIYDETTVNPEDEEVAFDEGTDEFSAYFNRLTNPKVLITTSDRPRGRTVRFCDQLATVIPHAYVYYRRGLALKKVIPQCISRGFTYLMVINEDRKVPNGMVLCHLPDGPTAHFKVSSVRLRKEMKRRGKNPTEHSPEVILNNFTTRLGHSIGRLFAALFPHDPQFVGRQVATFHNQRDFIFFRFHRYIFKNEKKVGIQELGPRFTLKLRSLQKGTFDSKFGEYEWVHKRHEMDSSRRKFHL
What is the function of this protein?
May be required for ribosome biogenesis.
What are the official names of this protein?
Ribosome production factor 1, Brix domain-containing protein 5, Ribosome biogenesis protein RPF1.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: T150A_XENTR
Sequence: MTGWIVLPISLTVFSIPGIWIVYAMAVMNHHVCPVENWTYNLTCTDDNTKAGTPKSCCTLEDVPLISKCGTYPPESCLFSLIGNVGAFMVVIICLLRYSQVIEVSQRSWLNTTALIAGCTNAAGLVMVGNFQVDYAKSLHYIGAGVAFPAGLLFVCLSSILSYQIAASALDYWLGHLRVSLTIVALISLVLSGVFFIQESFLMQHLAAICEWIFVLDILVFYGTFAYEFGSVSTDTMMAALQSSSARSCKSPGSSSTSTHLHCNAERIAMI
What is the function of this protein?
Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.
What are the official names of this protein?
Transmembrane protein 150A, Transmembrane protein 150.
What is the protein family that this protein belongs to?
Belongs to the DRAM/TMEM150 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KAD_ECO81
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAMKEAGINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYHQMTAPLIGYYSKEAEAGNTKYAKVDGTKPVAEVRAALEKILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAC_PYRHO
Sequence: MRKMMPMNPKQLKKLMKQLDMRQLEGVKEVIIKMEDREIIIKEPIVTVIKAMGEKMYQIAGGSEEEKAIINISEEDIKLVMEQAGVDYETAKKALEETGGDLAEAILRLTDSGVE
What is the function of this protein?
Contacts the emerging nascent chain on the ribosome.
What are the official names of this protein?
Nascent polypeptide-associated complex protein.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: C1TC_MOUSE
Sequence: MAPAGILNGKLVSAQIRDRLKNQVTRMQEQVPGFTPGLAILQVGDRDDSNLYINVKLKAAEEIGIKATHIKLPRTSTESEVLKYVISLNEDASVHGFIVQLPLDSENSINTEAVINAIAPEKDVDGLTSVSAGKLARGDLNDCFIPCTPKGCLELIKEAGVQIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTANLDKEVNKGDILVVATGQPEMVKGEWIKPGAVVIDCGINYVPDDTKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAQRFLQKFKPGKWTIQYNKLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSALDRLKHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLRQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGIRKFSDIQIRRLRRLGIEKTDPTTLTDDEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQSPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRERLGRMVVASSKKGEPISCEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYTEEDLDLVEKGFSNLRKQIENARMFGVPVVVAVNVFKTDTDAELDLVSRLSREHGAFDAVKCTHWAEGGQGALALAQAVQRASQAPSSFQLLYDLKLSIEDKIRIIAQRIYGADDIELLPEAQNKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
What is the function of this protein?
Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate.  These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance.
What are the official names of this protein?
C-1-tetrahydrofolate synthase, cytoplasmic, C1-THF synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLB_APLLI
Sequence: MSLSAAEADLAGKSWAPVFANKDANGDAFLVALFEKFPDSANFFADFKGKSVADIKASPKLRDVSSRIFTRLNEFVNNAADAGKMSAMLSQFAKEHVGFGVGSAQFENVRSMFPGFVASVAAPPAGADAAWTKLFGLIIDALKAAGK
What are the official names of this protein?
Globin, Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: HEM1_CHRSD
Sequence: MTLLALGINHKTATIEVREQVAFTPAELAGALAELKSLPGVNEAAVLSTCNRTELYCVTDSQGEREVLDWLGRFHALPPETLMQSAYHYLDGEAARHLMRVAAGLDSMVLGEPQILGQLKEAYQLARDNAGLGGELERLFQHTFSVAKQVRSETGIGENPVSVAYAAVSLASHIFDDFGRARALLIGAGETIELVARHLREAGIRGLTVANRTRERAELLAHEVDAEAISLGEIPQALAHADIIISSTASPLPILGKGMVESALKKRRHRPMFMVDIAVPRDIESQVGELDDVFLYSVDDLQEVIEENRKQRAVAAAQAESLIEHGIQHWQHERRVRGAGDLIRRYREQGEALREEAERQALAQLARGEDPEKVLQRLSRQLTNKLLHGPTLRLREASGEARHDILKAADTLLIDPAASTQDSA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: BMT2_KOMPC
Sequence: MRTRLNFLLLCIASVLSVIWIGVLLTWNDNNLGGISLNGGKDSAYDDLLSLGSFNDMEVDSYVTNIYDNAPVLGCTDLSYHGLLKVTPKHDLACDLEFIRAQILDIDVYSAIKDLEDKALTVKQKVEKHWFTFYGSSVFLPEHDVHYLVRRVIFSAEGKANSPVTSIIVAQIYDKNWNELNGHFLDILNPNTGKVQHNTFPQVLPIATNFVKGKKFRGAEDPRVVLRKGRFGPDPLVMFNSLTQDNKRRRIFTISPFDQFKTVMYDIKDYEMPRYEKNWVPFFLKDNQEAVHFVYSFNPLRVLKCSLDDGSCDIVFEIPKVDSMSSELRGATPMINLPQAIPMAKDKEIWVSFPRTRIANCGCSRTTYRPMLMLFVREGSNFFVELLSTSLDFGLEVLPYSGNGLPCSADHSVLIPNSIDNWEVVDSNGDDILTLSFSEADKSTSVIHIRGLYNYLSELDGYQGPEAEDEHNFQRILSDLHFDNKTTVNNFIKVQSCALDAAKGYCKEYGLTRGEAERRRRVAEERKKKEKEEEEKKKKKEKEEEEKKRIEEEKKKIEEKERKEKEKEEAERKKLQEMKKKLEEITEKLEKGQRNKEIDPKEKQREEEERKERVRKIAEKQRKEAEKKEAEKKGK
What is the function of this protein?
Beta-mannosyltransferase involved in cell wall biosynthesis.  Initiates the beta-mannosylation of core N-linked glycans (By similarity).
What are the official names of this protein?
Beta-mannosyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the BMT family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: SERA_SCHPO
Sequence: MDIKGGRRGNVEDSLNKLSLSPPDNNSSFLSNHFQVRKSYSQAPARTLKPFASEDIKILLLENVNQSALSNLKDEGYQVEFLKTSMSEDDLVEKIKGVHAIGIRSKTRLTRRVLEAADSLIVIGCFCIGTNQVDLDFAAERGIAVFNSPYANSRSVAELVIGYIISLARQVGDRSLELHRGEWNKVSSGCWEIRGKTLGIIGYGHIGSQLSVLAEAMGLHVVYYDILPIMPLGSAKQLSSLPELLHRADFVSLHVPASPETKNMISSKEFAAMKEGSYLINASRGTVVDIPALVDASKSGKIAGAAIDVYPSEPAGNGKDKFVDSLNSWTSELTHCKNIILTPHIGGSTEEAQYNIGIEVSEALTRYINEGNSIGAVNFPEVSLRSLTEADRNAARVLFVHRNVPGVLRQVNELFIDHNIKSQFSDSRGDIAYLVADISDCTPGSLEALHQKLESLPCKINTRLLY
What is the function of this protein?
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway.  Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
What are the official names of this protein?
Putative D-3-phosphoglycerate dehydrogenase, 3-PGDH, 2-oxoglutarate reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: HEXA_HUMAN
Sequence: MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
What is the function of this protein?
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:9694901, PubMed:8672428, PubMed:8123671).  The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2 (PubMed:11707436).  The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436).  Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:9694901, PubMed:8672428, PubMed:8123671).
What are the official names of this protein?
Beta-hexosaminidase subunit alpha, Beta-N-acetylhexosaminidase subunit alpha, Hexosaminidase subunit A, N-acetyl-beta-glucosaminidase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 20 family.
Protein: FMT_HELP2
Sequence: MRIVFMGTPGFAEVILRALVENKNNHIEVVGLFTQRDKPFGRKKELKAPETKTYILENRLNIPIFQPQSLKEPEVQILKDLKPDFIVVVAYGKILPKEILAIAPCINVHASLLPKYRGASPIHEMILNDDKIYGISTMLMDLELDSGDILESASFLREDYLDLDALSLKLAHMGATLLLSTLKNFHSITRKPQDHTQATFCKKITKADGLVGFKDAKNLFLKSLAFKSWPEIFLENNLKLLEVELVENEKSHKEGEILRIDEKGVLVGCLKGSVCIAWLQAVGKKPLKAKDYLNGKRLKVGGILA
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: RS18_WOLTR
Sequence: MTKKRNNFNDSYVSVNNRTGFKRSKVCPLATSQDEDIDYKNTDLLSRFTSDYGRILPRRLTGVCAKKQRKLRLAIIRARFLALVPYCTKKV
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: VTU4_DROSI
Sequence: MKIVALTLVAFVALAGASCPYAAPAPAYPAPAAPSGYPAPPCPTNYLFSCQPNLAPAPCAQEAQAPAYGSAGAYTEQVPHYVGSPNREQVQQFHQRIGMAALMEELRGLGQGIQGQQY
What is the function of this protein?
Major early eggshell protein.
What are the official names of this protein?
Vitelline membrane protein Vm32E.
What is the protein family that this protein belongs to?
Belongs to the vitelline membrane family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS2_RHIME
Sequence: MTDFTLSDLEKIVATRARAAPEESWTAKLVAAGQTKAAKKLGEEAVETVIAAIGEDRKNLVDESADLLYHLMVVLNIAAVPLQDVMSELARRTSQSGLQEKANRQNP
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEE_WOLSU
Sequence: MWVTRQDSVNFQQEYLIENKILDARSEKNTLEIFKSPAFEEIALLNQKQLLLKTLLSQESELLAHVPLCVHPTPKRVLIAGSFNLEVAFEALRHEETQVDFLQKDEKILHSLISFFPHFQETLHHPRFRVIEEIDSLKSYEVIIHTSLLSLEEIAPLFASLSLDGIFITRLENLLLHTESMRRYLLGIAHHFSIAMPFVSPFSLNADSHFLFASRRFHPQADLLLQRADMLEGLHCYHAELHESAFVLPKFLADSLQGSIKN
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_BACC1
Sequence: MIAIIDYGMGNIRSVEQALKHIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDVLEEKDLVRVLQEIGRSRKPLLGICLGMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWNELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISDYGVKVPGFVAKENIYGAQFHPEKSGDIGMQMLKNFKGVVESWKSSQLSI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEBP1_BOVIN
Sequence: MLGMIKNSLFGSVETWPWQVLSKGSKGDVFYEERACEGGKFATVEVTDKPVDEALREAMPKVMKYVGGSNDKGLGMGMTVPISFAVFPSDDGDLQKKLKVWFRIPNKFQSDPPAPSDDSIKIEDREGITVYSTQFGGYAKAADYAAQAAQLRSALESTAKYQTDFYFCTGYDPPMKPYGRRNEVWLVKSSE
What is the function of this protein?
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound.  Binds with a high affinity to one molecule of heme or porphyrins.  It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity).
What are the official names of this protein?
Heme-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the HEBP family.
What are the subcellular locations of this protein?
Cytoplasm.