PharMolix/UniProtQA huggingface dataset:
Protein: MURG_ACTPJ
Sequence: MAKKLLVMAGGTGGHVFPAIAVARELQKQGWEIRWLGTKDRMEADLVPKHGIPIEFIQISGLKGKGIGALLKAPFAIFKAVMQARKIIKNYQPDAVLGMGGYVSGPGGIAAKLCGVPVILHEQNAVAGLTNVWLSKIACRVLQAFPTAFPNAEVVGNPVREDLAQLEAPEIRFAERGYPINILVMGGSQGARVINQTVPEVAKQLGNNVFISHQVGKGNLGGVEEIYQATGNGIAAEFIDDMAQAYSWADLVICRSGALTVCEIAAAGLPAIFVPYQHKDRQQYLNATYLADGGAAIIIEQQDFTPQTLLNVLQPLIADRRKLTEMAVKARAKATPTAAQRVAEVIIEQAK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PTMK_PENSI
Sequence: MIIVTFFWVGIVLSAIWTFYKVVLYPYRVSPLRTLPQSQRGHWLWNHAFSEFLQPIGQLHAELLLQIPNDGMICLRGLFGAPKIFLTSPKSLADVLVHRADDFEKLPGERKILRAVVGDGLVTAEGDVHYQQKRKLLAGFTPPKIRALYPVFWKEATALTQQIRRTLTHDGSGIYTGTTDMVYWAPRVSMDMIGAAGFGQSFHSLRDADSEIIHCYEKAFAIGAGHLLCVFADTLLPRIILQWLPWPRWRQFRQNIDSIRDFCHQWVTDAKATTALGDGIPNNLLANMIHTGEYTFQELIEQVRTFLAAGHENTSSVVMWVMLALASDSQLQSRLRQELQANLPEVELDEVDLAILEQLPLLNAVVSEAIRLFPPLPIGNRIAIRDTTVMNHPIPKGTPFLIVPRAINRSSELWGPDADRFNADRWINPDTGRFNNHGGASSNYSFLSFFHGPHNCIGQNFARAELRTVVAAVIRSFDMVLDNPAADVSPVGWFTPRPADGVKVKLRSLV
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:25831977).  The geranylgeranyl diphosphate (GGPP) synthase ptmG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:25831977).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase ptmC then forms 3-geranylgeranylindole (3-GGI) (PubMed:25831977).  Epoxidation by the FAD-dependent monooxygenase ptmM leads to a epoxidized-GGI that is substrate of the terpene cyclase ptmB for cyclization to yield paspaline (PubMed:25831977).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase ptmP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase ptmQ (PubMed:25831977).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase ptmH which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase ptmD (PubMed:25831977).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase ptmV and ptmI leads to the production of the prenylated form of penijanthine (PubMed:25831977).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase ptmE (PubMed:25831977).  Five sequential oxidative transformations performed by the cytochrome P450 monooxygenases ptmK, ptmU, ptmL, ptmN and ptmJ yield the various penitrem compounds.  PtmK, ptmU and ptmM are involved in the formation of the key bicyclic ring of penitrem C via the formation of the intermediates secopenitrem D and penitrem D.  PtmL catalyzes the epoxidation of penitrem D and C to yield penitrem B and F, respectively.  PtmJ catalyzes the last benzylic hydroxylation to convert penitrem B to prenitrem E and penitrem F to penitrem A (PubMed:25831977).
What are the official names of this protein?
Cytochrome P450 monooxygenase ptmK, Penitrem biosynthesis cluster 2 protein K.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MURG_SYNC1
Sequence: MKLLLAGGGTGGHLFPAVALAQRLLEQDSEAQVQFVGTARGIEARVLPEQGWPLELIDIRGFVNQGLLGKLRMIPCLIRSVWQGLCILRKFQPDVVLGVGGYASAPMLVAARLKRIPTVIHEQNAWPGLTNRLLGPWARCVCLSFSEAERAFHRAATIVTGNPLRKGMEGCPPMDGDAPELLVFGGSRGARAINDAMLEALPRLEPWKDRLRIVHQTGGDDLQRIREGYARAGWPQESVVPFIDDMAAAYARAHLVVCRAGATTLAELAACGRAAILIPYPHAAADHQTVNARAMAKKGAGLVLAQQNLTPETLASLITDLLENRPRLISMSAAAKSLGITGAADRILRVCRNVCGQD
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BIOH_ALISL
Sequence: MTTSLYWQTEGEGSDLVLIHGWGMNGAVWQPIVEKLSSQYRVHTVDLSGYGYSAELGSADFDEMVAQVLAQAPEKSAWLGWSLGGLIATQAALTAPDRVSQLITVASSPRFAAEKGWRGIKSAVLSQFTEQLKEDFTLTVERFMTLQAMGSPNAKQDIKQVKRAVLSRPAPNPSALATGLTILADIDLRESLSQLTMPVCRMYGRLDGLVPIKVAHDMDAFIPHSTKVVFEQASHAPFISHSDEFITELHRFLQPEDEFLI
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_NOSP7
Sequence: MAEISAKLVQELRQKTGAGMMDCKKALIETEGNVEEAADWLRKKGISKAGAKSDRVAAEGLVDTYIQPGGQVGVLIEVNCQTDFVARNEAFKALVKNLAKQAAAADSVESLLAQQYADSPGGTVEEFIKQTIATLGENIQVRRFVNFALAEGTQGVVDSYIHTGGRVGVLVELGSQSESVATNQEFQSLARNTAMQVAACPNVEYVSVDQIPAEVAQKEKDIEMGKDDLANKPENIKEKIVQGRIEKRLKELTLIDQPYIRDQSISVEDLFKQAKTKLGEEIQVTRFVRYILGEGIEKQEISFADEVAAQMGGK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_NITEU
Sequence: MTHPLFRHAEFYTTVNRLQDLPQTAGVEVAFAGRSNAGKSSAINTLVGRERFAFVSKTPGRTQHINFFQLGEERFMVDLPGYGYAQVPLAIRQHWGHLLSSYLQTRQSLYGMILIMDIRHPLTKLDLQMLDWFRQTKKPVHVLLTKADKLSKSRALVALNEVRQFLTVNYPHCTVQTFSSLKVAGVEEASQLLQNWFDTGHASVQQENGEISEQKKTPAKGD
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: STK4_LEMCA
Sequence: METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFMDFVRQCLVKSPDQRATATQLLQHPFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQDDEENSEEDELDSGTMVRAVGDDMGTVRVASTMSDEANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQISSFGKSVPGPLKNSADWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
What is the function of this protein?
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.  Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.  Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.  Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.  Phosphorylates MOBKL1A, MOBKL1B and RASSF2.  Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).  Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner.  Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage.  Acts as an inhibitor of PKB/AKT1.  Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
What are the official names of this protein?
Serine/threonine-protein kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Protein: BIOB_AERS4
Sequence: MNAHTAGGHALRHDWTLSEVQALFALPFNDLLFQAQTIHRAHFDPNEVQVSTLLSIKTGACPEDCKYCPQSARYHTGLETERLMEVEKVLERAREARANGSSRFCMGAAWRNPKERDMPYILRMIEEVRGLGMETCMTLGMLTADQAARLGAAGLDYYNHNLDTSPEFYGEIISTRTYQDRLDTLEHVRGAGMKVCSGGIVGMGEQAKDRAGLLMALANLPRHPESVPINMLVKVKGTPLENEANLDSFEFIRTIAVARIMMPASHVRLSAGREKMNEQMQAMCFMAGANSIFYGCKLLTTPNPDENSDMQLFKRLGIRPAQRAQKPDQIQEEEILAEVSRQNAPDEMFYDATRPRAGVARS
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: UBIC_SHEDO
Sequence: MKVTSLSFPYGESIQWFSPERADSIQNAQLKDWLLATGSLTLKLKNLCNDFEVKVLGEQLTSPLATDTMIEETVWMREVLLCLDGTPWVFARTLVPQSLLDFKSQAFTQLGNKPLGELLYTSPEIIPGKIELAKFDTCSRLAKLATSLKQEISDPLWGRRRHFSIDTRHLTVSEIFLPAAVAHMKLHNK
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_CLOP1
Sequence: MELIIATRKSKLAQVQTEKVMELLKEKENVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKEIELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARIGTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVISDYFDPKVFLPAIGQGALGIECLKGGEFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSLIGAYSEVKDNDLYMIGTFTVNNRIVKKDILGNKEDNILLGKKLAEKILGEV
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CHEB2_DESVH
Sequence: MISVVVVDDSAFMRKALSTMLEKDPEIRVVATARDGEEGLQVIRQHNPDVVTLDIEMPRMDGLTTLRHIMMEMPRPVLMVSSLTTEGAEATLKALELGAVDFIPKQLSKVSLDIVRIENDLREKVKEVSKRRMLRTPRPVRPAPTASAPAQTAQVASAAPATAPSRPAMPATRASRPVRDVVAIGVSTGGPPAVQKVLSQLPADFPASILIAQHMPAAFTGPFAKRLDGVCAISVKEAESGEKLKPGTAYIAPGGKHLRVEQRVSHMEVVVTTDPADALYKPSANVLMESVGQSMGRRALGVILTGMGSDGMEGMKVLKQKGGRSIAQSDATCVVYGMPKAIVDAGLADEIVDIDDMAAAIMNGLYK
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 2.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_KORCO
Sequence: MPVVSFSRREMERLWRSLSEEELTDLLDFTKMNLESFGEEVGFEVTSDRMDLVTLEGIVRCLKGISNEELGLPKYRVRRKAFEVRVGEGVAKVRPYVVAALVRDVDLRTEESLVALIEAQEKIHDTLGRKRRRVAIGLHDFSKVKPPIIYDARRAEEVHFVPLGEYAEMSAKEILEQTEKGKIYSHLIANPENLVPLIMDSREEVLSMPPIINSELTRLTPGVRDIFIDVTGTDLKAIWYALEIISSALAERGGEISTLDILYPDGRNIETPRHEPEEMEVDLDFIRSILGLNLSEDDVVMQLLRARLDAECSDGKVRVLIPGYRSDFLHPIDVAEEVSITLGLNKIGYELPKNVMTVGRPHPVEKVSRKVRTVMIGLGYQEVLNYIMTSRASLFHAVGREEREVVEISNPVSESYSVLRDALFPGLLAFLANNTHVRYPQKVFEIGDVVLIDERLENKTRDERRVAAAYADDSVGFEDIYSHLKVLFENLSYRIELEPRKERPFIEGRCASVLREGEEVGVIGEIDPEVLLNLGITVPVAIFEVALKVPGKEPLT
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYAM_DROME
Sequence: MYNSAKQLQRVLTAREIRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTAAAPHKRVVNSQKCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSFGDYFKREACAMALELLRGPYNIDPGRLYVTYFAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDHRPDLGSVEQRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKSSNYDTDLFTPIFDGIQQAAKTPVYSGSFPDGGNAAVLDTSYRILADHARMVTACLADGMLPDQNQKLRRVLRKALNISEHVFAHDKLLTQLVPIVVETLGEAYPEMAAKQQAVIDLICHEQEVYKNLRESSSKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDFLYKLTDTYGLTEESFLKLAELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQAMLTKRLTPTDNSHKYTYSFDKESDSYQIPPLKTRVLGMLLNDAEVSRTQGSRIQQPFTDLISIVTAGSNFYYESGGQQSDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSSPTDAFQLAIGDEVELQVDAQQRQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGLLGKRIQKTDVQLIEDLINRVICSAAPVEVQLLSAAEVLEQNDITMVPGEVYPEQGLRLVNVESPELQLSSKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLKTAALLRHRVDLLEKQFQTDKLTNATEAELQTIRHNMLHTDIKLPYAFKMDTLERITEMLKRIKDSSRTTLKEFVDVEMRTLLQEKPLDTHPFILHYITSSALVEEIPLQRATKLCPDRPILVISVCDSVVKARCCVPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVSNLFEEQLEQAMSKAHAYAKLYL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, mitochondrial, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HFQ_SINFN
Sequence: MAERSQNLQDLFLNTVRKQKISLTIFLINGVKLTGVVTSFDNFCVLLRRDGHSQLVYKHAISTIMPGQPLQMFENEEAAS
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: GATB_AGRVS
Sequence: MTLVDTRTPDPKRLIPGATGDWEIVIGMEVHAQVLSQSKLFSGASTTFGNAPNDNVSLVDAAMPGMLPVINEECVRQAVRTGLGLKAKINKRSIFDRKNYFYPDLPQGYQISQFKDPIVGEGKIIISLGPDRQGNFEDIEIGIERLHLEQDAGKSMHDQHPTMSYVDLNRSGVALMEIVSKPDMRSSDEAKAYMTKLRSIVRYLGTCDGNMDEGSMRADVNVSVRKPGGEFGTRCEIKNVNSIRFIGQAIEYEARRQIAILEDGGSIDQETRLFDPGKGETRSMRSKEDAHDYRYFPDPDLLPLEFDDAFVQALKKDLPELPDDKKARFVASLGLSVYDASVLVSEKAIADYYEAVAAGRDGKIAANWVINDLLGALNKAGKGIEETPVSPAQLGGIIDLIKAETISGKIAKDLFEIVFNEGGDPADIVESRGMKQVTDTGAIEKAVDEIIAANPDQVAKVLAKPTLAGWFVGQVMKATGGKANPQAVQALVKAKLGLEE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: 3S11_BUNFA
Sequence: RICLNQQQSTPEDQPTNGQCYIKTDCQNKTWNTHRGSRTDRGCGCPKVKPGINLRCCKTDKCNE
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin 1, Toxin V-II-1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SGIP1_ARATH
Sequence: MEKSQKQVTRPSNSRREYSKEIPIDLLIEIFSRLSTGDIARCRCVSKIWSSVPRLRDFTELFLKISSARPRILFTFLHNGMVPSYDNEIHAPVRGFLCSKASVYNPSTGECAYPYLELLGLWDILPVDAENLAKKVCVPKVLLASEDFACRVSTLGTEEVCWRMIQCSLPHRPFRDEICIDGVLYYLANCKGKLGILWPVPSGDQSHEVTRSFVLRILEDANKLIWSRTVYTLSFNWKKLVNKSLYIVGMTSGGEIVLSTRHLNYPFYIVYYNPVNNTAAKNEIQFGNIANKKAENSRIYTFIDHVENVEHMD
What is the function of this protein?
E3 ubiquitin-protein ligase which triggers the ubiquitination and subsequent degradation of SGS3 in response to heat (PubMed:30778176).  Involved in the mechanisms necessary for quick response to heat and subsequent heritable transgenerational memory of heat acclimation (global warming) such as early flowering and attenuated immunity; this process includes epigenetic regulation as well as post-transcriptional gene silencing (PTGS) (PubMed:30778176).  In response to heat, HSFA2 is activated and promotes the expression of REF6 which in turn derepresses HSFA2, thus establishing an heritable feedback loop able to trigger SGIP1 and subsequent SGIP1-mediated SGS3 degradation; this prevents the biosynthesis of trans-acting siRNA (tasiRNA) and leads to the release of HTT5, which drives early flowering but attenuates immunity (PubMed:30778176).
What are the official names of this protein?
E3 ubiquitin-protein ligase SGIP1, SGS3-INTERACTING PROTEIN 1.
What are the subcellular locations of this protein?
Cytoplasmic granule. Note=Co-localizes with SGS3 in cytoplasmic granules.
Protein: PSBD_SYNJB
Sequence: MTIAVGRVRQERGWFDIVDDWLKRDRFVFIGWSGLLLFPCAYLALGGWLTGTTFVTSWYTHGLASSYLEGCNFLTVAVSTPADSMGHSLLLLWGPEAQGDFTRWCQIGGLWTFVALHGALGLIGFMLRQFEIARLVGVRPYNAIAFSAPIAVFVSVFLIYPLGQSSWFFAPSFGVAGIFRFLLFFQGFHNWTLNPFHMMGVAGVLGGALLCAIHGATVENTLFQDGEAASTFRAFEPTQSEETYSMVTANRYWSQIFGIAFSNKRWLHFFMLFVPVTGLWMSSIGVVGLALNLRAYDFISQEVRAAEDPEFETFYTKNILLNEGIRAWMAPQDQPHERFEFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: SFSA_PROM4
Sequence: MIGKSLLTFSTLNEGILLKRYKRFLADVELDTGHIVTAHCANTGPMTGVLKPGGRVRVRYAPSPSRKLSWSWEQAQVVNQAGNRIWVGVNTALPNKIVRLAIEAGCFREALGEIARIRNEVKYGRTGNSRIDLLLTPGENNCDQRQIFLEIKNTTWTDGSLALFPDTVTERGQKHLQEMIDVLPNARALLVPCISRNDVDLFAPGDAADPIYGNLFRQALSEGVEVMPCCFGFFSDHITWEGMRPFRETQTIFPLP
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: TATB_PSEF5
Sequence: MFGISFSELLLVGLVALLVLGPERLPGAARTAGLWVGRLKRSFNAIKQEVEREIGADEIRRQLHNEHILSLEQEARKILAPTQQQPTPVEPVAEQTIHAPGAATVAEAPPASEVPAPLPSTPAPAPTAEPAAPVATPATTAPHDSTLPPRAP
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NMAT3_ARATH
Sequence: MVLRLRVHSFYNRGISFLVSSSLRNLSTASSLFLNSDQTITEPLVKSELEALVLKQYSHGKFYSLVKNAVSLPCVLLAACQNLSLSANSSGDLADRVSRRFSIEEMGREIREGRFDIRSCCVEFISSSLVLPNLKLKVLIEAIRMVLEIVYDDRFATFSYGGRVGMGRHTAIRYLKNSVENPRWWFRVSFAREMFEERNVDILCGFVGEKINDVMLIEMIKKLFEFGILKIELGGCNSGRGFPQECGLCSILINVYFDGLDKEIQDLRLKMKVKNPRVGTGDEESTGNVFFKPVNIYAVRYLDEILVITSGSKMLTMDLKKRIVDILEQRLELRVDRLNTSIHSAVSEKINFLGMYLQAVPPSVLRPPKSEKAVRAMKKYQRQKDVRKLELRNARERNRKTLGLKIFRHVLKKIKQSNGFKFEGEIENEVRDIFQSWGEEVMQDFMGSLEERWKWHWLLTRGDFLSLRHIREKLPQDLIDAYDEFQEQVDKHLAPTQAKKVLEDEERRVEEEEEQRYAERTVEDLTKLCMKVSAPEELVRKAIKLVGFTNSMGRPRPIIHLVTLEDSDIIKWYARHEKHGSTKKLIRHYTKDLRVSDLDGREEAHFPSEREVKMMGDKNLSDPKPVDGTLSLLLIRLASDEPLHHCAASFCERSDTIMHRVHLLQNRLHINPLDEEKWVPGMGTIHSALNRKCLPLCSTHISDVYLGKITLQDVDSSSFIDLR
What is the function of this protein?
Nuclear-encoded maturase required for splicing of group-II introns in mitochondria.  Necessary for mitochondrial biogenesis during early developmental stages.
What are the official names of this protein?
Nuclear intron maturase 3, mitochondrial, AtnMat3, Nuclear intron maturase 2 a, AtnMat2a.
What is the protein family that this protein belongs to?
Belongs to the plant nuclear intron maturase (nMat) family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MFM2_SCHPO
Sequence: MDSIATNTHSSSIVNAYNNNPTDVVKTQNIKNYTPKVPYMCVIA
What is the function of this protein?
M-factor is a mating pheromone produced by M-type mating cells.  All three mfm genes contribute to the production of M-factor.
What are the official names of this protein?
M-factor.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.