PharMolix/UniProtQA huggingface dataset:
Protein: FRD_KLEP3
Sequence: MTSNERILQPFTLPNGTELKNRLLMAPMTTCTGYFDGTVTSELVEYYRARAGSIGTIIVECCFIDDYGLAFPGAIGIDNDEKIAGLAKIAEAIKAQGSKAILQIYHGGRMVDPQLIGGRQPVAPSAIAAPREGAAMPRALSGEEVEGMIAKFGDGVRRAILAGFDGVEIHGANTYLIQQFYSPNSNQRDDEWGGSRDNRARFPLAVLDITHKMARQYADDAFIIGYRFSPEEMEVPGIRFDDTMYLLEKLAARGVDYLHFSVGATLRPSIVDTSDPTPLIEKYCAMRSETLAQVPVMGVGGVVNVADAELGLDHGYDLIAVGRACIAYPDWAARIAAGEELELFIDSTQREALHIPEPLWRFSLVEAMIRDMSMGDAKFKPGMFVETVQDDANELVINVSLENDHIADIELAASPVQTVEFTTSFEEIRERILTANTPHVDAISGATSQSEAVKKAVAKAMLKSSKALAAEEGGNDAAPKSYDVVVVGSGGAGLAAAIQAHDEGASVLIVEKMPTIGGNTIKASAGMNAAETRFQRVKGIQDSKELFYQETLKGGHNKNNPQLLRRFVENAPQAIEWLADRGIMLNDITTTGGMSIDRTHRPRDGSAVGGYLISGLVRNITKRGIDVLLDTSVEEILMSGDEVSGVRLVNDEKEVIEVQTKSIVVATGGFSANSAMVVKYRPDLDGFVTTNHKGATGSGIALLERIGAGTVDMGEIQIHPTVEQQTSYLISESIRGGGAILVNQQGNRFFNEMETRDKVSAAIIALPEHYAYIVFDEHVRAKNKAADEYIAKGFVTSASSPRELAEKLGMDYHAFLATLECYNGAVEKQHDEQFGRTTALRAPINEGPFHAIRIAPGVHHTMGGVTINTDGEVLNVDQQPIRGAYAAGEVVGGIHGGNRIGGNAVADIIIFGTLAGHQAAKRARG
What is the function of this protein?
Catalyzes the anaerobic reduction of fumarate to succinate (PubMed:24361839, PubMed:33107907).  Uses NADH as the inherent electron donor in this process (PubMed:33107907).  Is involved in anaerobic fumarate respiration in K. pneumoniae (PubMed:33107907).
What are the official names of this protein?
NADH:fumarate oxidoreductase, Fumarate reductase, FRD.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_SHESA
Sequence: MSNKLVLVLNCGSSSLKFAVIDAQTGDDQISGLAECFGLEDSRIKWKINGEKHESSLGAFTAHREAVEFIVNKILAGQPELAAQIQAVGHRIVHGGEKFTRSVIIDEHVIKGIEECSSLAPLHNPAHLIGIRAAIASFPKLPQVAVFDTAFHQSMPERAYIYALPYKLYREHGIRRYGMHGTSHLFVSREAAKVLNKPLEETNVICAHLGNGASVTAVKGGKSVDTSMGLTPLEGLVMGTRCGDLDPSIIYHLVHQLGYTLEEVNNLMNKQSGLLGISELTNDCRGIEEGYADGHKGATLALEIFCYRLAKYIASYTVPLGRLDAVVFTGGIGENSDIIREKVLNMLQIFNFHVDSERNKAARFGKKGIITTDNSTVAMVIPTNEEWVIAEDSIKLITK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_YEAS1
Sequence: MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVNGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELETLEAKGLKNARSRLFVSSRAHLVFDFHQVTDKLRELELSGRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQPGAWEEFVARYKRLLETRRQRYGDFEYDFEAKPAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKEIK
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPB_LEPIC
Sequence: MKLDKLTSKLNEAIYNAQASAEKLGNPEISEEHILKEVLSQPDGLVPLLISKLNLSPKSFLESTENALGKQPKVGGNTSADVGFSRSAVSLLKAADEVRKELKDEYLSTDHILLGLMKNGTGSLKTEFLKLGLEYHKLLKITLENRKGKTIMDDSPEGKTDALAKYAKNLNELAKQGKLDPVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLANKIVQGEVPEGIKNKTLYTLDLGSMIAGAKYRGEFEDRLKALLDEVKSSDGEVILFIDEIHTLVGAGATEGALDASNMLKPMLARGELRCIGATTLKEYQKYIEKDAALERRFQPVYVKEPSVEETVTILRGLKGRYELHHGIRILDSALIAAATLSNRYISDRFLPDKAVDLIDEASSKMRIEIDSMPEELDRANKRIQSLKIEREALKKEQDTASKERLKTLERDLSEQEQNFQTLKARWDLEKSKIGRLKQIKEEIEKYKNLEAEAERRGEINRVAEIRYGKLVDLQKELESANEELKKQESASRLLKEEVSEEDIANIVSRWTGIPVSKMLQGERAKLLLMEDVLKTKVIGQDHALRLVSEAVQRSRAGIADPNRPIGTFLFLGPTGVGKTETAKALAEFLFDDVNAMTRIDMSEYMEAHSVARLIGAPPGYVGYDEGGQLTEAVRRRPYSLILFDEIEKANPEVFNIFLQILDEGRLTDGKGRNVDFKNTVIILTSNIGSEILGSSEYTSEEKERLVEQRLKKHFKPEFLNRIDEVILFHSITDSVIHKIADIQLEGLRQKAKENGLDVSFTNELKDYVSKAGFDAEYGARPLKRLIQREVGNALSRYILDGKFTNGQNVTVDYRQGKVVVVV
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSXA1_MOUSE
Sequence: MKRRSHSVNLGKTKHKPEETCQAFEDISKYFSKEEWKKLSRSEKITYVYMKRNYTTMTNLGLRAHLPDFMESKERVTKSVLSDSDEVSSHESQDKRKNPVV
What is the function of this protein?
Could act as a modulator of transcription.
What are the official names of this protein?
Protein SSXA1, Synovial sarcoma, X member A1.
What is the protein family that this protein belongs to?
Belongs to the SSX family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCH1_SERP5
Sequence: MTSLSKEAVLVHAALEERGLETPLRGEVLDRETRKRRIKEHMTEIMQLLNLDLSDDSLAETPHRIAKMYVDEIFSGLDYANFPKITVIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDAVIGLSKINRIVQFFSQRPQVQERLTQQILVALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHQG
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: GSA2_STAAB
Sequence: MNFSESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMKEGRGAYLYDVDGNKFIDYLQAYGPIITGHAHPHITKAIQEQAAKGVLFGTPTELEIEFSKKLRDAIPSLEKIRFVNSGTEAVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGPSQLGSPDSAGVPESVAREVITVPFNDINAYKEAIEFWGDEIAAVLVEPIVGNFGMVMPQPGFLEEVNEISHNNGTLVIYDEVITAFRFHYGAAQDLLGVIPDLTAFGKIVGGGLPIGGYGGRQDIMEQVAPLGPAYQAGTMAGNPLSMKAGIALLEVLEQDGVYEKLDSLGQQLEEGLLKLIEKHNITATINRIYGSLTLYFTDEKVTHYDQVEHSDGEAFGKFFKLMLNQGINLAPSKFEAWFLTTEHTEEDIKQTLKAADYAFSQMK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 2, GSA 2, Glutamate-1-semialdehyde aminotransferase 2, GSA-AT 2.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOT1_MERUN
Sequence: LSILAFVDMVARPSMGLAANTKWIRPRIQYFFAASVVANGVCHLLAPLSTSYIGFCVYAGVFGFAFGWLSSVLFET
What is the function of this protein?
Bidirectional proton-coupled monocarboxylate transporter.  Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (By similarity).  The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate.  MCT1 is a major lactate exporter (By similarity).  Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity).  Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart.  Functions via alternate outward- and inward-open conformation states.  Protonation and deprotonation is essential for the conformational transition (By similarity).
What are the official names of this protein?
Monocarboxylate transporter 1, MCT 1, Solute carrier family 16 member 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CCTS_TALIS
Sequence: MNFRCSSPLWYDDHLSDCVVNHYLSTLIPLTACLASAIACLISYFHARQNAKHIDTGFHPVASSEDEAVDQIAHVSQQYITAIPPVIEKLEVALILAEISIAIFLLIFSGENTDLTSVFASAVSSIYLLLILFVRLTRSLQSYVDLQPHSSVLYTLQWTCLTAIVHAAILGNSERNFTIATLVRFALFTFLCLFHWTAPRIPVEPYDEDHVLFLDPSEDETASLLSRMTFSWLDKLVWKAYRATLQVSDLYQLNHNHRSGVVAPRFKNTATNSLLWRLFGFFKSDLLWQGAWATLNSFAVFVPPVLMRSLLEYLEVPDLASQSTAWLYVTGLLVAGIVAGVAGCQCDWKGREMAARTRAVLINEIYTKVLRKGVALHLQTNSEQPEAADNFASDGNIFNLLTVDTEHVSEMSGYLYLVWITFPVQTAIGTYLLYRLLGISGIVGVALMLGLLPLNILISRRLVAVQARVLTASDARIQASSEILNNVRTIKYSAWEAVFKKRVLSKRRIELVEMRSRFIWWSINMTTFFSLPLIVTILTLFFYTVVWDNSMGTAVAFPALVIFSILRIPFNRIADAITFLLRAHVSLGRIEKFLQEQETGKYEQLSRTDSVEVGFNNATLTWPNGGFGNKAVTENKRSDIQLTELPSMRPFKLKGLNIRFQPGALNVICGPSGSGKSSLLLALLGEMALVNGQVFLPHKHNWHELSTDSLTETTAYCPQEAWILNRTIRANIVFDLPFDGRRYEAVLEAVALRPDIASFDQGDQTLAGEGGSRLSGGQKQRVSLARALYSRSKYVLLDDCLSAVDSKTANHIFFHAVKGDLMQGRTCMFATNSIQLTIPHCDYIVLLDDGRVRGQGTAEELVSEGRIDADIMQNKAEFGSEKPGAYDTIELDHAIKSPSSRSSLDTVSLLEVDPQQEDPEAGYEESKAEGAVAWSVIRTYLVTLGPPWYWVLVLFMFGIQQFISLATNIWIKEWAVRYDMLDNFAFDPIQRNATTRDETLDEPEEPQKVQARYYMAIYVAICLAYAFFTFARDLIVFYGSLKASSEIYERLLNSVLFAKLLFFDRIPLGQITNRFSRDVEVLDQNISTFSINTLQIAASLVMIIVFISSVVPAFLIAAVFICVAYWFVMTIFINGARDLRRIESVERSPVYQQFSEALSGCVSIRAYARASIFTAQNQVLVDRLNSPYLLQWASQQWLGFRVNFLGSLILFFTGAFVVWDLESVDPSSAALVLTYAAMFSESIMWFVQLYAIVQQNLNSVERVVEYTEIEQEANQPLKRAVYDLPEDWPSRGGVRFDAYTTRYAPELPPVLNDITFNVPPGKRVAVVGRTGAGKSTLTLALIRGLEAELGRIEIDGIDISEVTLDRLRQAVTVVPQDPGVFRGTLRDNLDPLHLYSNEEMIETLRAVRLLDAVRTYIPGNSATPLDCLDHPANALSRGQRQLLCIARTLLRRSRVLVFDEATASIDHTTDAAIQESLRASVTVGTTVITVAHRLLTIADYDKVVVLDAGCVAEQGSVQELLDRDDDGIFRRLCVQSGDLEKIERVAAEKSGRK
What is the function of this protein?
ABC transporter; part of the gene cluster that mediates the biosynthesis of the mycotoxin cyclochlorotine, a hepatotoxic and carcinogenic cyclic chlorinated pentapeptide (PubMed:26954535).  With the MFS transporter cctQ, is most likely responsible for cyclochlorotine secretion and thereby may contribute to intrinsic resistance (PubMed:26954535).
What are the official names of this protein?
ABC transporter cctS, Cyclochlorotine biosynthesis protein S.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: APGM_METS3
Sequence: MKGIVLVMDGMGDRPLKEFDNQTPLQAANTPNMDEMAKNGITGIMDSIAPGIIPGSDTAHLSILGYDPYEVYTGRGPFEAAGVGVDVIPGDIAFRCNFSTADENGIVTDRRAGRIREGTHEIVEVLNTMVLEDYPDIKIIFKESTGHRAVLVLRGEGLSDKVSDADPKVEGNKPKEVIPLDDSVEAKKTADILNKLVVKSYEMIKDHPVNLERIENNEPPANIIIPRGAGEVPVVEALNDKYEVNSACIAETGLIMGIGRFAGMDIIEMEDVTGGIDTNLENIRDTIIDQVKNSDHDFFLINIDGADEAGHDGQAVEKRDFIEKVDRVVMSELKKLEDVYIFLTADHSTPISVLNHSGDPVPVIITGPEVRVDDVCEYSEVAVAKGGLCRIRGADVMNIMMDLMNYAHKFGA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, aPGAM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Protein: PSA_SULTO
Sequence: MAFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTTLGVKTKAGVVLIGEKRKATQLLDVDSIEKVFILDDHVGCSFAGLASDGRILIDYARSQALQHRLIYDEPINIDYLTKLVSDVKQMYTQHGGVRPFGVALIIGGIDRGKTPKLLMTEPSGQFMPYYAVAIGQGGYTATEYFEKNYREDLNMQDTILLGIRALASTLKPGEKLAPSNIEVGFADVDSGMFRKMSFEERASILQKL
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PsmA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STXB_BPH30
Sequence: MKKTLLIAASLSFFSASALATPDCVTGKVEYTKYNDDDTFTVKVGDKELFTNRWNLQSLLLSAQITGMTVTIKTNACHNGGGFSEVIFR
What is the function of this protein?
The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
What are the official names of this protein?
Shiga-like toxin 1 subunit B, SLT-1 B subunit, SLT-1b, SLT-Ib, Verocytotoxin 1 subunit B, Verotoxin 1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the stxB family.
What are the subcellular locations of this protein?
Secreted.
Protein: IOVO_DENAC
Sequence: VATVDCSDYPKPACTLEYMPLCGSDNKTYGNKCNFCNAVVDSNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPA_STRP2
Sequence: MSYQDLKECKIITAFITPFHEDGSINFDAIPALIEHLLDHHTDGILLAGTTAESPTLTHDEELELFAAVQKIVNGRVPLIAGVGTNDTRDSIEFVKEVAEFGGFAAGLAIVPYYNKPSQEGMYQHFKAIADASDLPIIIYNIPGRVVVELTPETMLRLADHPNIIGVKECTSLANMAYLIEHKPEEFLVYTGEDGDAFHAMNLGADGVISVASHTNGDEMHEMFIAIAESDVKKAAAIQRKFIPKVNALFSYPSPAPVKAVLNYMGFEAGPTRLPLVPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_VIBVY
Sequence: MAKTIQAIRGMNDCLPTQSPLWQKLEGAVKNVISAYGYNEMRMPIVEMTHLFSRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIENGLLYNQEQRVWYMGPMFRHERPQKGRYRQFHQCGVEVFGLNGPDVDAELIMMTARLWRELGIDKHVRLELNSIGSLEARANYRTALIAFLEQHIDVLDEDCKRRMHTNPLRVLDTKNPDVQAILGDAPRLSDYLDPESTQHFAGLCELLDAAGIEYTVNERLVRGLDYYNRTVFEWITESLGSQGTVCGGGRYDGLVEQLGGKATPAVGFAMGLERLVLMLETLELTDVRRSVDVYVVTAGEGTMMAGMKLAEQVREAIPGVRVMNHFGGGNFKKQFKRADKVGAVVALVLGENEVADNTVVLKDLAGGEQVTYSQQEIASKIAELI
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GA2_GIBF5
Sequence: MPLMDVHWLIYVAFGAWLCSYVIHVLSSSSTVKVPVVGYRSVFEPTWLLRLRFVWEGGSIIGQGYNKFKDSIFQVRKLGTDIVIIPPNYIDEVRKLSQDKTRSVEPFINDFAGQYTRGMVFLQSDLQNRVIQQRLTPKLVSLTKVMKEELDYALTKEMPDMKNDEWVEVDISSIMVRLISRISARVFLGPEHCRNQEWLTTTAEYSESLFITGFILRVVPHILRPFIAPLLPSYRTLLRNVSSGRRVIGDIIRSQQGDGNEDILSWMRDAATGEEKQIDNIAQRMLILSLASIHTTAMTMTHAMYDLCACPEYIEPLRDEVKSVVGASGWDKTALNRFHKLDSFLKESQRFNPVFLLTFNRIYHQSMTLSDGTNIPSGTRIAVPSHAMLQDSAHVPGPTPPTEFDGFRYSKIRSDSNYAQKYLFSMTDSSNMAFGYGKYACPGRFYASNEMKLTLAILLLQFEFKLPDGKGRPRNITIDSDMIPDPRARLCVRKRSLRDE
What is the function of this protein?
Ent-kaurene oxidase; part of the gene cluster that mediates the biosynthesis of gibberellins (GAs), diterpenoids that may provide a selective advantage during infection of the preferred host plant, rice (PubMed:23825955, PubMed:9917370, PubMed:10347043, PubMed:12750377, PubMed:15925394).  Gibberellins (GAs) are diterpenoids and are synthesized via the mevalonate pathway (PubMed:12750377).  Biosynthesis of the major metabolite GA3 (gibberellic acid) from geranylgeranyl diphosphate (GGPP) requires 13 steps (PubMed:12750377).  The GGPP produced by the geranylgeranyl diphosphate synthase GGS2 is converted to ent-kaurene via ent-copalyldiphosphate in a two-step cyclization reaction performed by the bifunctional ent-copalyl diphosphate synthase/ent-kaurene synthase enzyme (CPS/KS) (PubMed:9745028, PubMed:10803977, PubMed:12750377).  Ent-Kaurene is metabolized to GAs by a series of oxidation reactions catalyzed by cytochrome P450 monooxygenases (PubMed:9917370, PubMed:12750377).  Cytochrome P450 monooxygenase P450-4 is an ent-kaurene oxidase that catalyzes the three oxidation steps between ent-kaurene and ent-kaurenoic acid (PubMed:11472927).  The highly multifunctional cytochrome P450 monooxygenase P450-1 then catalyzes four steps involving oxidation at two carbon atoms, in the main pathway from ent-kaurenoic acid to GA14 via GA12-aldehyde as well as producing kaurenolides and fujenoic acids as by-products (PubMed:11320210).  The cytochrome P450 monooxygenase P450-2 then converts GA14 to GA4 by removal of C-20 (PubMed:11943776).  GA4 is further converted to GA7 by the GA4 desaturase DES via 1,2-desaturation before cytochrome P450 monooxygenase P450-3, a 13-hydroxylase, hydroxylates GA7 to GA3, the final product of the GA-biosynthetic pathway (PubMed:12750377).
What are the official names of this protein?
Ent-kaurene oxidase P450-4, Cytochrome P450 monooygenase 4, P450-4, Gibberellin cluster kaurene oxidase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MATRX_EBLV1
Sequence: MKIIRKIVKSCKDDEMQKPNPVSAPPDDDDLWLPPPEYVPLSEMTGKKNMRNFCINGEVKVCSPNGYSFRIIRHILSSFEGVYSGNRRMIGLVKVVIGLALSGAPVPDGMNWVYKIRRTLIFQWAESSGPLDGEELEYSQEITWDDDSEFVGLQMRVSARQCHIQGRLWCINMNSRACQLWSDMSLKTQQSDEDKNTSLLLE
What is the function of this protein?
Plays a major role in assembly and budding of virion.  Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form.  Inhibits viral transcription and stimulates replication.  Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity).
What are the official names of this protein?
Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein.
Protein: DOT2_ARATH
Sequence: MEVEKSKSRHEIREERADYEGSPVREHRDGRRKEKDHRSKDKEKDYDREKIRDKDHRRDKEKERDRKRSRDEDTEKEISRGRDKEREKDKSRDRVKEKDKEKERNRHKDRENERDNEKEKDKDRARVKERASKKSHEDDDETHKAAERYEHSDNRGLNEGGDNVDAASSGKEASALDLQNRILKMREERKKKAEDASDALSWVARSRKIEEKRNAEKQRAQQLSRIFEEQDNLNQGENEDGEDGEHLSGVKVLHGLEKVVEGGAVILTLKDQSVLTDGDVNNEIDMLENVEIGEQKRRNEAYEAAKKKKGIYDDKFNDDPGAEKKMLPQYDEAATDEGIFLDAKGRFTGEAEKKLEELRKRIQGQTTHTFEDLNSSAKVSSDYFSQEEMLKFKKPKKKKQLRKKDKLDLSMLEAEAVASGLGAEDLGSRKDGRRQAMKEEKERIEYEKRSNAYQEAIAKADEASRLLRREQVQPFKRDEDESMVLADDAEDLYKSLEKARRLALIKKEEAGSGPQAVAHLVASSTNQTTDDNTTTGDETQENTVVFTEMGDFVWGLQRENDVRKPESEDVFMEEDVAPKAPVEVKEEHPDGLTEVNDTDMDAAEDSSDTKEITPDENIHEVAVGKGLSGALKLLKDRGTLKEKVEWGGRNMDKKKSKLVGIVDDDGGKESKDKESKDRFKDIRIERTDEFGRTLTPKEAFRLLSHKFHGKGPGKMKEEKRMKQYQEELKLKQMKNSDTPSQSVQRMREAQAQLKTPYLVLSGHVKPGQTSDPQSGFATVEKDVPGSLTPMLGDRKVEHFLGIKRKSEPGNSDTPPKRPKP
What is the function of this protein?
Plays a role in root, shoot and flower development.  Probably required for normal root and shoot meristem organization and maintenance and the proper expression of PIN and PLT genes (PubMed:19000164).  Involved in leaf vasculature patterning (PubMed:18643975).
What are the official names of this protein?
SART-1 family protein DOT2, Protein DEFECTIVELY ORGANIZED TRIBUTARIES 2, Protein MERISTEM-DEFECTIVE.
What is the protein family that this protein belongs to?
Belongs to the SNU66/SART1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS15_AQUAE
Sequence: MVLPKDVKWDLIRQFQRHEQDTGSPEVQIAILTERINRLTEHMKKHKKDIHSRRGLIAMVNKRRKLLEYLRETDYAKYLEVVQKLNLKVK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: PKR2_RAT
Sequence: MGDQNGNTSFAPDLNPPQDHVSLLPLNYSYGDYDIPLDDDEDVTKTQTFFAAKIVIGVALAGIMLVCGVGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKRMNYQTASFLIALVWMVSILIAIPSAYFTTETILVIVKNQEKLFCGQIWPVDQQLYYKSYFLFVFGLEFVGPVVTMTLCYARISQELWFKAVPGFQTEQIRKRLRCRRKTVLLLMGILTAYVLCWAPFYGFTIVRDFFPTLVVKEKHYLTAFYVVECIAMSNSMINTICFVTVKNNTMKYFKKMLLLHWRPSHYGSKSSADLDLKTSGVPATEEVDCIRLK
What is the function of this protein?
Receptor for prokineticin 2.  Exclusively coupled to the G(q) subclass of heteromeric G proteins.  Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity).
What are the official names of this protein?
Prokineticin receptor 2, PK-R2, G-protein coupled receptor 73-like 1, G-protein coupled receptor I5E.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IDH_AQUAE
Sequence: MNKTTFENVYYWEGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPVYWMGQATPIPNPERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRIE
What are the official names of this protein?
Isocitrate dehydrogenase [NADP], IDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Protein: MAO1_ECO5E
Sequence: MEPKTKKQRSLYIPYAGPVLLEFPLLNKGSAFSMEERRNFNLLGLLPEVVETIEEQAERAWIQYQGFKTEIDKHIYLRNIQDTNETLFYRLVNNHLDEMMPVIYTPTVGAACERFSEIYRRSRGVFISYQNRHNMDDILQNVPNHNIKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNQQLLNDPLYMGWRNPRITDDEYYEFVDEFIQAVKQRWPDVLLQFEDFAQKNAMPLLNRYRNEICSFNDDIQGTAAVTVGTLIAASRAAGGQLSEKKIVFLGAGSAGCGIAEMIIAQTQREGLSEEAARQKVFMVDRFGLLTDKMPNLLPFQTKLVQKRENLSDRDTDSDVLSLLDVVRNVKPDILIGVSGQTGLFTEEIIREMHKHCPRPIVMPLSNPTSRVEATPQDIIAWTEGNALVATGSPFNPVVWKDKIYPIAQCNNAFIFPGIGLGVIASGASRITDEMLMSASETLAQYSPLVLNGEGLVLPELKDIQKVSRAIAFAVGKMAQQQGVAVKTSAEALQQAIDDNFWQAEYRDYRRTSI
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: CLAPI_STYCL
Sequence: MKTIILILLILGLGIDAKSLEESKADEEKFLRFIGSVIHGIGHLVHHIGVALGDDQQDNGKFYGYYAEDNGKHWYDTGDQ
What is the function of this protein?
Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria.  Has potent hemolytic activity.
What are the official names of this protein?
Clavaspirin.
What are the subcellular locations of this protein?
Secreted.
Protein: MURQ_SYMTH
Sequence: MELNRLVTEGRLQESLEIDQVSTLEMVRIINEQDKQVALAVEKELPHIARAVDLIAERLRAGGRLFYVGAGTSGRLGILDASEIPPTYGAPPDLVQGVIAGGLEAVFRTREGAEDSREQGAADIAARVRPGDVVVGIAASGRTPYTVAALEEARRLGCATVAVTNNPDSALAAAADVAIAPVVGPEVIMGSTRMKAGTAQKMVLNMLSTGAMIRLGKVYSNLMVDMQASNEKLRHRAVRMVVQATGRDEDAAARALEEAGGSVKQAIVALLAGVDARTAREALDRAGGYVREAIRLAQGK
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: ERPA_BUCBP
Sequence: MKNNISKFPLSFSKSAIKKIKTIISEKNIPNLKFRVYIAGGGCSGFQYKFKFDKNKNKNDTIVNIFNNIIIIDPISLQYLRGGQIDYIENLEGSKFIILNPKAKHTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.