PharMolix/UniProtQA huggingface dataset:
Protein: OPSG_SCICA
Sequence: MAQRWDPQRLAGGQPQDSHEDSTQSSIFTYTNSNATRGPFEGPNYHIAPRWVYHITSTWMIIVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAIADLAETVIASTISVVNQLYGYFVLGHPLCVVEGYTVSVCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIIPLSIIILCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATANPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDTSELSSASKTEASSVSSVSPA
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.  May increase spectral sensitivity in dim light.
What are the official names of this protein?
Medium-wave-sensitive opsin 1, Green cone photoreceptor pigment, Green-sensitive opsin, Medium wavelength-sensitive cone opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CLPP_SHESA
Sequence: MHNASDIQSALVPMVIEQTAKGERSFDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLESESPDKDIFLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKRFCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLNLMLSEHTGQPLEVIERDTDRDNFMSATQAVEYGLVDAVMTKRG
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBG_NEUCR
Sequence: MPREIITIQAGQCGNSIGSQFWQQLCLEHGISQDGTIEDFATEGGDRKDVFFYQSDDTRYIPRSILIDLEPRVINTIQTGPYRNIYNPENFYVGKSGLGAGNNWGDGYQTGEQVHEEIMEMIEREADGSDSLEGFMMLHSIAGGTGSGLGSFLLERLNDRFPKKIIQTYSVFPDTTSAGDVVVHPYNSLLAMRRLTQNADSVVVLDNGALSHIAADRLHVQEPSFQQTNQLVSTVMSASTTTLRYPGYMHNDLVSILASLIPTPRCHFLMTSYTPFTGDQVEQAKTVRKTTVLDVMRRLLQPKNRMVSTVPGKKSCYISILNVIQGDVDPTDVHKSLLRIRERRLATFIPWGPASIQVALTKRSPYVTMAHRVSGLMLANHTSIATLFKRIVRQYDGMRKRNAFMEAYKKTAPFSENLNEFDEAREVVMDLIADYEAAEDANYLNPELGENASADTDKRMA
What is the function of this protein?
Tubulin is the major constituent of microtubules.  The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
What are the official names of this protein?
Tubulin gamma chain, Gamma-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: RBFA_BORA1
Sequence: MSRHKSKSIPGRNLRLAEQIQKDLAGIIQREIDMTRAGLITLSGVELSADYAHAKVYFTVLGAEPDTAAALLNEKAGWLHSQLYKLLHIHTVPTLRFVHDPQLERGIEMSMLIDRANRGPHSGVPDEPEDQS
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMA5_ARATH
Sequence: MATKLLSLTCIRKERFSERYPLVRKHLTRSRDGGGGSSSETAAFEIDDPISRAVFQVLGMTCSACAGSVEKAIKRLPGIHDAVIDALNNRAQILFYPNSVDVETIRETIEDAGFEASLIENEANERSRQVCRIRINGMTCTSCSSTIERVLQSVNGVQRAHVALAIEEAEIHYDPRLSSYDRLLEEIENAGFEAVLISTGEDVSKIDLKIDGELTDESMKVIERSLEALPGVQSVEISHGTDKISVLYKPDVTGPRNFIQVIESTVFGHSGHIKATIFSEGGVGRESQKQGEIKQYYKSFLWSLVFTVPVFLTAMVFMYIPGIKDLLMFKVINMLTVGEIIRCVLATPVQFVIGWRFYTGSYKALRRGSANMDVLIALGTNAAYFYSLYTVLRAATSPDFKGVDFFETSAMLISFIILGKYLEVMAKGKTSQAIAKLMNLAPDTAILLSLDKEGNVTGEEEIDGRLIQKNDVIKIVPGAKVASDGYVIWGQSHVNESMITGEARPVAKRKGDTVIGGTLNENGVLHVKVTRVGSESALAQIVRLVESAQLAKAPVQKLADRISKFFVPLVIFLSFSTWLAWFLAGKLHWYPESWIPSSMDSFELALQFGISVMVIACPCALGLATPTAVMVGTGVGASQGVLIKGGQALERAHKVNCIVFDKTGTLTMGKPVVVKTKLLKNMVLREFYELVAATEVNSEHPLAKAIVEYAKKFRDDEENPAWPEACDFVSITGKGVKATVKGREIMVGNKNLMNDHKVIIPDDAEELLADSEDMAQTGILVSINSELIGVLSVSDPLKPSAREAISILKSMNIKSIMVTGDNWGTANSIAREVGIDSVIAEAKPEQKAEKVKELQAAGHVVAMVGDGINDSPALVAADVGMAIGAGTDIAIEAADIVLMKSNLEDVITAIDLSRKTFSRIRLNYVWALGYNLMGIPIAAGVLFPGTRFRLPPWIAGAAMAASSVSVVCCSLLLKNYKRPKKLDHLEIREIQVERV
What is the function of this protein?
Involved in copper import into the cell.  May play a role in copper detoxification in roots.
What are the official names of this protein?
Probable copper-transporting ATPase HMA5, Probable copper-transporting ATPase 3, Protein HEAVY METAL ATPASE 5.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL15_BUCAP
Sequence: MRLNTLSPSLGSRKNHKRLGRGIGSGFGKTAGRGHKGQKSRSGGHVNRGFEGGQMPIYRRIPKFGFNSRKKNITAEVRLSDISKLSTDIIDLKVLKKENIINKNIKYVKIILSGKLEVALTLHGLRVTRGARLAIENYGGKIEG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PSBN_WELMI
Sequence: METATLVTISISCLLVSFTGYAIYTSFGRPSEQLRDPFEDHED
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: TOMT_PANTR
Sequence: MGTPWRKRKGIAGPGLPHLSCALVLQPRAQVGTMSPAIALAFLPLVVTLLVRYRHYFRLLVRTVLLRSLRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSCCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHMVELIVGSSEDVIPCLRTQYQLSRADLVLLAHRPRCYLRDLQLLEAHALLPAGATVLADHVLFPGAPRFLQYAKSCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG
What is the function of this protein?
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity).  Required for auditory function (By similarity).  Component of the cochlear hair cell's mechanotransduction (MET) machinery.  Involved in the assembly of the asymmetric tip-link MET complex.  Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells.  The function in MET is independent of the enzymatic activity (By similarity).
What are the official names of this protein?
Transmembrane O-methyltransferase, Catechol O-methyltransferase 2, Protein LRTOMT2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
What are the subcellular locations of this protein?
[Isoform 1]: Membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Endoplasmic reticulum. Note=Localized to the cell body of the cochlear hair cells, but is not present in the stereocilia. Present but not restricted to the apical cistern, Hensen's body and the subsurface cistern.
Protein: TRAF6_MOUSE
Sequence: MSLLNCENSCGSSQSSSDCCAAMAASCSAAVKDDSVSGSASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHIIEDCPRRQVSCVNCAVSMAYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPIPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLALRPCDAASPSRGCRPEDPNYEETIKQLESRLVRQDHQIRELTAKMETQSMYVGELKRTIRTLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEALIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVSTRFDMGGLRKEGFQPRSTDAGV
What is the function of this protein?
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2 (PubMed:15322147, PubMed:17633018).  Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity).  Leads to the activation of NF-kappa-B and JUN.  Seems to also play a role in dendritic cells (DCs) maturation and/or activation (PubMed:14499111).  Represses c-Myb-mediated transactivation, in B-lymphocytes (By similarity).  Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:10421844, PubMed:10215628).  Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (PubMed:10421844, PubMed:17092936).  Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (PubMed:12881420).  Participates also in the TCR signaling by ubiquitinating LAT (By similarity).
What are the official names of this protein?
TNF receptor-associated factor 6, E3 ubiquitin-protein ligase TRAF6, RING-type E3 ubiquitin transferase TRAF6.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family. A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet. Note=RSAD2/viperin recruits it to the lipid droplet.
Protein: PST1_YEAST
Sequence: MQLHSLIASTALLITSALAATSSSSSIPSSCTISSHATATAQSDLDKYSRCDTLVGNLTIGGGLKTGALANVKEINGSLTIFNATNLTSFAADSLESITDSLNLQSLTILTSASFGSLQSVDSIKLITLPAISSFTSNIKSANNIYISDTSLQSVDGFSALKKVNVFNVNNNKKLTSIKSPVETVSDSLQFSFNGNQTKITFDDLVWANNISLTDVHSVSFANLQKINSSLGFINNSISSLNFTKLNTIGQTFSIVSNDYLKNLSFSNLSTIGGALVVANNTGLQKIGGLDNLTTIGGTLEVVGNFTSLNLDSLKSVKGGADVESKSSNFSCNALKALQKKGGIKGESFVCKNGASSTSVKLSSTSKSQSSQTTAKVSKSSSKAEEKKFTSGDIKAAASASSVSSSGASSSSSKSSKGNAAIMAPIGQTTPLVGLLTAIIMSIM
What is the function of this protein?
Has a partially redundant function to ECM33 in cell wall integrity.  May be involved in a repair mechanism activated in response to cell wall damage.
What are the official names of this protein?
Cell wall mannoprotein PST1, Haze protective factor 2, Protoplast secreted protein 1.
What is the protein family that this protein belongs to?
Belongs to the SPS2 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Identified as GPI-anchored plasma membrane protein (GPI-PMP) as well as non-covalently-linked, soluble protein of the cell wall. Secreted by regenerating protoplasts. In budded cells, concentrates at the surface of the buds.
Protein: BMP4_XENLA
Sequence: MIPGNRMLMVILLSQVLLGGTNYASLIPDTGKKKVAADIQGGGRRSPQSNELLRDFEVTLLQMFGLRKRPQPSKDVVVPAYMRDLYRLQSAEEEDELHDISMEYPETPTSRANTVRSFHHEEHLENLPGTEENGNFRFVFNLSSIPENEVISSAELRLYREQIDHGPAWDEGFHRINIYEVMKPITANGHMINRLLDTRVIHHNVTQWESFDVSPAIMRWTLDKQINHGLAIEVIHLNQTKTYQGKHVRISRSLLPQKDADWSQMRPLLITFSHDGRGHALTRRSKRSPKQQRPRKKNKHCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
What is the function of this protein?
Posterior-ventralizing factor in Xenopus mesoderm induction.  Induces posteroventral mesoderm and counteracts dorsalizing signals such as activin.
What are the official names of this protein?
Bone morphogenetic protein 4, BMP-4.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: CATV_GVXN
Sequence: MLFFNFYKHIMFLPWVFCVALLTLNVCAVSYIAYDMSNAQELFNEFVVKYNKVYKDDQEKEARFEIFKQNLADINARNALEDSAMFEINSRADISSNELLQKLTGLKLSLMRGEKKNSFCTPTVISGDSSGKVPDSFDWRDRNSVTSVKMQKECGSCWAFSAVANIESLYHIKHNVSLDLSEQQLVDCDKVNNGCNGGLMSWAFEGIIRAGGISYEAPYPYTGVDGVCKNTTRYVQLSGCYAYDLRSEKKLRQVLHEKGPVSVAIDVVDLTNYKSGVAKHCSVDHGLNHGVLLVGYGQENDVKYWTLKNSWGSDWGEQGFFRIKRDVNSCGILNQFAASAILSSSS
What is the function of this protein?
Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus.  May participate in the degradation of foreign protein expressed by the baculovirus system (By similarity).
What are the official names of this protein?
Viral cathepsin, V-cath, Cysteine proteinase, CP.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: TIN3O_HOPOC
Sequence: RICTAIPLPMCL
What is the function of this protein?
Stimulates insulin release from beta cells at a concentration of 100 nM and release of glucagon-like peptide 1 (GLP-1) from enteroendocrine cells at a concentration of 1 uM in vitro.  Reduces secretion of interferon gamma from peritoneal cells in a mouse model.  Has no inhibitory activity against Gram-positive bacterium B. megaterium Bm11 or Gram-negative bacterium E. coli ATCC 25922 at concentrations of up to 100uM.  Has no hemolytic activity against mouse erythrocytes.
What are the official names of this protein?
Tigerinin-3O.
What are the subcellular locations of this protein?
Secreted.
Protein: GCVHL_STRPG
Sequence: MKKIANYLLIEKTDDRYTISMTPELQDDIGTIGYAEFTDNDHLAVDDIILNLEASKTVMSVLSPLAGAVVERNEAATLTPTLLNSEKAEENWIVVLTDVDQAAFDALEDA
What is the function of this protein?
May act as a carrier protein for the ROS scavenging lipoyl moiety and/or as a substrate for oxidoreductases such as SpyM50865 and SpyM50866.
What are the official names of this protein?
Glycine cleavage system H-like protein, GcvH-L.
Protein: RL9_GEOMG
Sequence: MKVILKENLENLGHIGDIVKVAPGYARNYLLPRGYATEATEKNAKALEHAKRQLEYKRNKVLEQAKGLAAKIEGLTIAITHQAGEEGKLFGAVTNMELAEHLKAQGVEIDRKKIVLAEPIKHVGEYTASVKVHPEVAAALKVVITKAD
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: TGT_XANOR
Sequence: MSRLQFQLQATDGHARRGRLTFPRGTVETPAFMPVGTYGSVKGILPEHIRALGAEIILGNTFHLYLRPGLDVIGDHGGLHGFARWDGPILTDSGGFQVFSLAHRRKITEQGVTFSSPTDGARVFLGPEESMKIQKVLDSDIVMIFDECTPYPATEDLARRSMELSLRWAQRSRDAHDGLGNDAALFGIVQGGVHPDLRSRSLDGLQSIGFDGYAIGGLAVGEPEHERNAMLEHLHPRLPAECPRYLMGVGRPEDLVEGVARGVDMFDCVMPTRNARNGHYFTSFGTVRIRNAKYERDLDTIEPGCGCHACSSGYTRSYLRHLDRCNEMLAPMLGTLHNLWYYEKLMADMRAAIASGTFVEFRRSFYAARGATTPPLPGETS
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: SYGB_LISMO
Sequence: MSKDFLLEIGLEEMPAQYVTSSVLQLEKRVTDWLTENKIEFGEIKTYSTPRRLTVLVEGMAEEQANRVEEAKGPAKKIALDEEGNWSKAALGFAKSQKVDPADLTFRDIKGVEYIYIKKEVIGEKTSTLLPSLEKVVTSMTFPVSMHWGSNDLRYIRPIKWLIAMFDEEIIPFEITGVTTSNTSRGHRFLGKSATIKQPSDYPNALLEQFVVVNAEERKQAIVEQLRELESMENWQIKEDDDLLEEVTNLVEYPTVLSGNFEKEYLELPEEVLITTMKEHQRYFPVFSQAGELLPHFVTVRNGNHENLDTVARGNEKVLRARLSDADFFYQEDLKMTIDEAVAKLQNIVFHEKLGTLTEKMKRVQKVALMLADYLDWQEEDKQDIIRLTNIYKFDLVTNIVGEFPELQGLMGEKYALLQGEKPAIATAIREHYLPNSAEGELPQTDLGSLIAIADKLETLIGFFCVNIVPTGSADPFGLRRSAFGAMRIIQANGWNIPMLEVISRIVDMERAEGSTELPDADVKKEVQTFLKNRLRVILQGHHIRHDIIDAVIGGDPNVIPQLIDRAQILNEHAEAEWFRPTIEALSRVVKIAKKYEDGVEVDPALFENEYEQALFDKLEKLKFDYAGLTIIERLKAFADLRTTIDAYFDNTLVMSDNDELKNNRLALLFELASFIKEFAQMDEINVK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRLF2_RAT
Sequence: MRAVTWAIVAMLLPRVLGAIPTRTPRTGGVGDTLSVAIVCHDLESVEVTWGPGSAHHGLSANLSLEFRYGNQVPQPCPHYFLLDSVRAGCVLPMGKGLLEVVLREGGGAKLFSRKKKASAWLRPRPPWNVTLSWVGDTVAVSCPSHSYPGLEYEVQHRDDFDPEWQSTSAPFCNLTVGGLDPGRCYDFRVRATPQDFYYGPEARPSKWTGVASLQGVGPTGSCTGPTLPRTPGTPTPPLALACGLAVALLTLVLLLALLRMRRVKEALLPGVPDPRGSFPGLFEKHHGNFQAWIADSQAAVPTVPEQDKDDDVIRPQTKGVETQEDDDVIAPGSPCLGGGALMSVGGASFLMGDSGYTTL
What is the function of this protein?
Receptor for thymic stromal lymphopoietin (TSLP).  Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5 (By similarity).  Also activates JAK2 (By similarity).  Implicated in the development of the hematopoietic system.
What are the official names of this protein?
Cytokine receptor-like factor 2, Thymic stromal lymphopoietin protein receptor, TSLP receptor.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 5 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RUVA_CLOB6
Sequence: MYEYIKGKYIDMYKDYIVIENNNIGYKIYTSGSTMAKLPSIGENIMLYTEQIVREDFIGVYGFLTKDELSMFKLLLTINGVGAKAALSLLSISNVSTLKYAIKMGDEKTITRAPGIGKKTAQRIILELKDKIEIDILEEDDEQTINKVTDDKKVLEAVAALITLGYSEKEANKVINSCDKNNSLEQIIKEALKYLMK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RS20_ACIBS
Sequence: MANSAQAKKRARQNVKARKHNASLRSMVRTYIKRTLSAIAGGDYAVATEAYKKAVPVIDRMADKGIIHKNKAARHKSRLNAQVKALAN
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RPOB_STRZT
Sequence: MAGHDVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFKAFLDHGLKEVFEDVLPISNFTDTMELEFVGYEIKEPKYTLEEARIHDASYSAPIFVTFRLINKETGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVIPNRGAWLELESDSKDITYTRIDRTRKIPFTTLVRALGFSGDDEIFDIFGDSELVRNTVEKDIHKNPMDSRTDEALKEIYERLRPGEPKTAESSRSLLVARFFDPRRYDLAAVGRYKINKKLNVKTRLLNQTIAEPLVDPETGEILVEAGTIMTRSVIESIESHLDGDLNKIVYIPNDAAVVTEPVVLQKFKVVAPTDPDRVVTIIGNANPDDKVRTVTPADILAEMSYFLNLAEGLGRVDDIDHLGNRRIRAVGELLANQVRLGLSRMERNVRERMSVQDNEVLTPQQIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSSYGHLNKYGFVQTPYRKVDRETGVVTNEIVWLTADEEDEYTVAQANSRLNEDGTFAEKIVMGRHQGVNQEYPANIVDYMDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLINPQAPYVGTGMEYQAAHDSGAAVIAQYDGKVTYADADKVEVRREDGSLDVYHIQKFRRSNSGTAYNQRTLVKVGDVVEKGDFIADGPSMENGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEYESETRDTKLGPEEITREIPNVGEDALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGADGVVRDVKIFTRVNGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARTLGIHIATPVFDGASSEDLWSTVKEAGMDSDAKTILYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSTVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVLQEILTYKSDDINGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDQEVELRDLDEGMDEDVIHVDDLEKAREKAAQEAKAAFEAEEAEKATKAEATEEAAEQE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: VGFR3_RAT
Sequence: MQPGAALNRRLWLCLGLLQGLANGYSMTPPTLNITEDSYVIDTGDSLSISCRGQHPLEWTWRGAQEVLTTGGKDSEDTQVVQDCEGTEARPYCKVLSLAQTHANNTGSYYCYYKYIKARIEGTTAASTYVFVRDFEQPFINKPDTLLVNRKDSMWVPCLVSIPGLNITLRSQSSVLHPDGQEVLWDDRRGMRVPTLLLRDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLYPKKSLELLVGEKLVLNCTVWAEFDSGVTFDWDYPGKQAERAKWVPERRSQQTHTELSSILTIHNVSQHDLGPYVCEANNGIQQFRESTEVIVHEKPFISVEWLKGPVLEATAGDEMVKLPVKLAAYPPPEFQWYKDRKAVTGRHNPHALVLKEVTEASAGVYTLALWNSAAGLRQNISLELVVNVPPHIHEKEASSPSIYSRHSRQTLTCTTYGVPQPLSVQWHWRPWTPCKTFAQRSLRRRQPRDGMPQCRDWKEVTTQDAVNPIESLDTWTESVEGKNKTVSKLVIQDANVSAMYKCVVFNKVGQDERLIYFYVTTIPDGFSIESEPSEDPLEGQSVRLSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCEVQDRRSQDKHCHKKYLSVQALEAPRLTQNLTDLLVNVRTSLEMRCPVAGAHVPSIVWYKDERLLEKESGIDLADSNQRLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILIGTGVIAVFFWVLLLLIFCNMKRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDVSQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVKRETFDPYAEKSPEQRRRFRAMVEGAKADRRRLGSTDRALFTRFLMGKGSARRAPFVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEECMALHSSQSSEEDGFMQASTTALHITEADAESSPPSMHCHSLAARYYNCVSFPGRLVRGTKAPGSSRMKTFEELPMTPTTYKASVDNQTDSGMVLASEEFEQIESRHRQEGSFSRKDPGQHMDISRGHPDLQGRRRRPTQGAQGGKVFYNNEYGEVSQPCTEGDCCPSAGSTFFADSNY
What is the function of this protein?
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development.  Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting.  Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling.  Modulates KDR signaling by forming heterodimers.  Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway.  Phosphorylates SHC1.  Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase.  Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473' (By similarity).
What are the official names of this protein?
Vascular endothelial growth factor receptor 3, VEGFR-3, Fms-like tyrosine kinase 4, FLT-4, Tyrosine-protein kinase receptor FLT4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=Ligand-mediated autophosphorylation leads to rapid internalization.
Protein: RS13_THEPD
Sequence: MSGEFRYIVRVAGVDLPGDKALVYALADIKGIGVSTAQAVAKKLGLDPYRLLGTLSEEEVEKLSAALREIEKLGLPPWMLNRRKDPFLGVDRHLITSDLLITVRNDIEFMKKIKSYKGVRHMLGLKVRGQRTRTTGRTGLTVGVKRGKEKAQQQKGG
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.