PharMolix/UniProtQA huggingface dataset:
Protein: COAX_CLOBA
Sequence: MILLVDAGNTNIVLGVYKDKKYIASWRISTEGNKTSDEYSIQIMQLLNLNNLNPEDVKGIIVSSVVPNIMHSLENMLRRCFGQEPIIVGPGIKTGINIKYDNPKEVGADRIVNAVAAFEIYKRPVIIIDFGTATTFCSVTENGDYLGGCICPGLRISADALFEKAAKLPRVELEVPRKVICKNTVSSIQSGVLFGYIGQVEYIVKKMKEEMNDGIEPYVIATGGLANLIANETDAIDKVDSDLTLEGLKILYKKNRE
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLD_XYLFT
Sequence: MNERSTPQALTGPVIRAESLGKTYSEGKLLTQVFDGLDLQVMRGETVAIVGASGAGKSTLLHLLGGLDVPTAGEVYVAGQRMSALSDGDRGRLRNKTLGFIYQFHHLLPEFTALENVMMPVLLSGQSVCSAKMRAQMLLEAVELGHRLNHKPSELSGGERQRAAVARALANSPDCVLGDEPTGNLDNRTASTVFELMLELNRAQRTSLVLVTHDRGLARCLDRVLELYQGGLRELTSAEV
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RUVB2_ASHGO
Sequence: MSIQTQEAHDMSLKSLSLIATHSHIVGLGLDENLQPKPSSQGMVGQLQARRAAGVILKMVQNGTIAGRAVLVAGPPSTGKTALAMGLSQSLGADVPFTAMAGSEIFSLELSKTEALTQAFRKSIGVKIKEDTELIEGEVVEIQIDRSITGGHKQGKLTIKTTDMETIYELGNKMIDGLTKEKVLAGDVISIDKACGKITKLGRSFARSRDYDAMGPDTKFVQCPEGELQKRKSVVHTVSLHEIDVINSRTQGFLALFTGDTGEIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEFAPIVIMATNRGISKTRGTNYKSPHGLPLDLLDRSIIITTQNYSEQEIKTILSIRSQEEEVELTEDALDLLTKIGGETSLRYSSNLIAVSQQIAQKRKSSSVDVQDVKRAYLLFLDSTRSAKYLQEYESRYIDDHGRVDISTTGRNADAMDTNE
What is the function of this protein?
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.  The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair.  Also involved in pre-rRNA processing (By similarity).
What are the official names of this protein?
RuvB-like helicase 2.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PATS_NOSS1
Sequence: MKAIMLVNFCDERGSGR
What is the function of this protein?
Inhibits heterocyst differentiation; a peptide corresponding to the last 5-6 amino acids blocks heterocyst formation when added exogenously in culture.  Controls heterocyst pattern formation through intercellular signaling mechanisms.  In Nostoc filaments, approximately every 10th vegetative cell terminally differentiates into a heterocyst specialized for nitrogen fixation.  Seems to inhibit the formation of adjacent heterocysts (PubMed:9794762, PubMed:11274121, PubMed:15051891).  The C-terminal peptide binds HetR, inhibits hetR transcription and blocks the DNA-binding of HetR.  Peptide binding to HetR alters its conformation, probably leading to dissociation of the HetR-DNA complex and cessation of transcription (PubMed:26576507).
What are the official names of this protein?
Transcriptional regulator peptide PatS, Heterocyst inhibition-signaling peptide.
What are the subcellular locations of this protein?
Periplasm. Note=Probably diffuses to adjacent cells.
Protein: PDXJ_XANP2
Sequence: MAVLKPVRLGVNVDHVATVRNARGGALPDPVRAAALAKAAGAHGITAHLREDRRHIRDADMERLKAEIDLPLNFEMAATDEMVAIACRVRPNACCLVPERREERTTEGGLDAAGQRAELAPRIARLKAAGIRVSLFIAADPAQIAAAAELGADIVELHTGAWCDAVTEGRHVEAEAEFVRLKAGARQAAGLGLEVHAGHGLDYATAERIAAFPQIVELNIGHFLIGEAIFVGLDQAIARMRAAIAAGRAAVGDGAAA
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CK091_BOVIN
Sequence: MPKGRRGSQSPTMSQRPAPPLYFPSLYDRGISSSPLSDFNIWKKLFVPLKAGGAPAGGAPAAGGRSLPQGPSAPAPPPPPGLGPPSERPCPPPWPSGLASIPYEPLRFFYSPPSGPEAAASPLAPGPMTSRLASASHPEELCELEIRIKELELLTITGDGFDSQRYKFLKALKDEKLQGLKTRQPGKKSASLS
What are the official names of this protein?
Uncharacterized protein C11orf91 homolog.
Protein: ASSY_ECO5E
Sequence: MTTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELQIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGATHEAKDLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRWVASQITGEVTLELRRGNDYSILNTVSENLTYKPERLTMEKGDSVFSPDDRIGQLTMRNLDITDTREKLFGYAKTGLLSSSAASGVPQMENLENKGQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4II_SINFN
Sequence: MRRRSTEGTVMTDGSKPTFEIGIAMSGAISAGAYSAGVFDFLIQALDAWEKAKAEGAPDLPEYDVRLKALSGASAGAITAAIGVIAAGGREAPATFPSPAPGSQNIRFTLGRLYRSWVTSPTLVSPDGSPDLLSLEDLAGGRPVISVLNANVLTAIGAEALEATGTLSPRAYVASSLHLYMMLSNLRGVPYAIHFNGGQYNMMTHADRVHYVVEGIGTWKPTPSPFADTDSGTSIAATSLFGAAGASTRPPEWLAFANAALASGAFPIGLSPRVIATATSQYAKAKFPISEDQSELRPIPTWPDAWHVSASQDYPFSFVSVDGGLINNDPFEFVRFTLMKDPPRPNERNAEKADRAVIMIAPFPEGPPFLGDGEPPLGVLSIARRVVTALRQQVRFKPDQLLAVAAEGTHSRFMISPHRVPPSTPGGEEREETFSIASGLLGGFGGFVLEAFRDHDYQLGRRNCQYFLMRHLTIDKNHQTLHWPEGAAERRNAVISKTLSDGSMHDYVPIIPLVGDALPEVPYPRWARIDENAFALLVKRIEARLVAVARRLVSTETTSARMKLGLNFLLLVGRNRIVDYIRLTLLQELVMRDQIEGWPLPAADLRPDFVRAVLAALLDPAFDLRTEAGIARTTKLDTSLVREILSTLAGAAGANCQVWLAPWTRTDEPSLYTLVSRRPSFLATLLQGRSPARLFAKPVVDRK
What are the official names of this protein?
Uncharacterized protein y4iI.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ILVC2_BACCR
Sequence: MKTYYEKDANVELLQGKTVAVVGYGSQGHAQAQNLRDSGVEVVVGVRPGKSYEVAKADGFEVMSVSEAVRTAQVVQMLLPDEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTALHVALAYAKGVGCTRAGVIETTFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEGGLTTMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTYNAMKKAEQNHQLEKVGAELREMMSWIHAPKELVKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)) 2, KARI 2, Acetohydroxy-acid isomeroreductase 2, AHIR 2, Alpha-keto-beta-hydroxylacyl reductoisomerase 2, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ATPB_VIBVY
Sequence: MATGKIVQIIGAVVDVEFPQSDVPSVYDALNVKDSKERLVLEVQQQLGGGVVRCIVMGSSDGLRRGVEVVNTGAPISVPVGTKTLGRIMNVLGDAIDERGEIGAEELYSIHRPAPSYEEQSNATELLETGVKVIDLICPFAKGGKIGLFGGAGVGKTVNMMELINNIALQHSGLSVFAGVGERTREGNDFYHEMQEAGVVNIEKPEESKVAMVYGQMNEPPGNRLRVALTGLTMAERFRDEGRDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKQGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLNRNIAAMGLYPAIDPLDSTSRQLDPLVVGQEHYDTARGVQQTLQRYKELKDIIAILGMDELSESDKQVVARARKIERFLTQPYHVAEVFTGDPGVYVPLKETLRGFKGLLAGEYDDIPEQAFMYCGTIDEAIENAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YIHI_ENT38
Sequence: MKKPTSAAGAKRPTKAHRKTREELNQEARDRKRVKKHSGHSAGSRANGSSASGSTAQNSKQKDPRIGSKTPIPLGVTDTPVVKQHKPKSEKPMLSPQAELDMLENDERLDALLERLEAGEKLNAEEQKWVDAKLDRIDELMQQLGLSYEDDEDDEEEEKQDDMMRLLKGGN
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: PANC_ECOSE
Sequence: MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSSIADKLQAGERDLDEIITIAGQELNEKGFRADDIQIRDADTLLEVSETSKRAVILVAAWLGDARLIDNKMVELA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_MYCA9
Sequence: MTAPNPSSLVAPIRVPAGTTAGTAVREAGLPGKGEDAIVVVRVDGALKDLSWTPESDTEVEPVAANTEDGRSVIRHSAAHVLAQAVQELFPQAKLGIGPPITDGFYYDFGIDHAFTPEDLTALEKKMKQIIKEGQRFSRRVYESVEEAQAELANEPFKLELVSDKSGADDPEVMEVGGDELSAYDNLNPRTGEREWFDLCRGPHIPTTKHIPAFRLTRSSAAYWRGNQANASMQRVYGTAWESQEALDKHLELLEEAQRRDHRKLGVELDLFSFPDEIGSGLPVFHPKGGIVRKELEDYSRAKHTAAGYEFVNTPHITKENLYQTSGHLDWYSDGMFPPMHIDAELNEDGTVRKPGQNYYLKPMNCPMHHLIYRARGRSYRELPLRLFEFGSVYRYEKSGVVHGLTRVRGMTQDDAHIYTTREQMHEELTSLLRFVLDLLSDYGLDDFYLELSTKDEAKFVGSDEVWEEATKTLEQVALDSGLQLVPDPGGAAFYGPKISVQAKDALGRSWQMSTIQLDFNMPERFNLEYTAADGTRKQPVLIHRALFGSIERFFGVLTEHYAGAFPAWLSPVQAVGIPIADAHAPYLNDIVSQLKAQGIRAEVDSSDDRMNKKIVNHTNQRVPFLLLAGDRDVEAGAVSFRFRDRTQVNGVPRDEAVAAIVDWVNRRENVSPTAELLKLGASD
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_CHRSD
Sequence: MAAKQIKFSDDARKRMARGVNVLADAVKVTLGPKGRNVVLEKSFGSPTVTKDGVSVAKEIELKDKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQSIVTEGMKGVTAGMNPMDLKRGIDQAVDAAVKEIQSLSVPCTDAKAIAQVGTISANGDKRIGEIIADAMQKVGKEGVITVDEGRGFEDELEVVEGMQFDRGYLSPYFVTNQDTMMVELEDPYLLMVDKKISNIRELLPVLEAVAKSGKPLGIIAEDIEGEALATLVVNTMRGIVKAAATKAPGFGDRRKAMLQDIAILTGGTVISEEVGLTLEQANLDHLGSAKRVTMSKENTTIIDGAGVEADIEARVSQIRAQIEDTSSDYDREKLQERVAKLAGGVAVIRVGAATEFEMKEKKARVEDALHSTRAAVEEGVVPGGGTALVRILNKLVDLKGDNEDQTHGIAIALRAMEAPLRQIVTNAGQEASVIVNQVKAGEGNYGYNAQTGEYGDLFDMGVLDPAKVTRSALQSAGSVAGLMITTEAMIADDPDEKEAGGGAPDMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_RHOBA
Sequence: MTPMMRQYHEAKEACGDALLFFRMGDFYELFLDDAKVAAGILGLTLTSRDKDSENPTAMAGFPHHQLDQYLQKLIRAGFRAAVCEQVEDPKAAKGLVRREITRVVSAGTLTDEGLLDPKEPNYLAAVFAPSQKAREKAQKEAAKTNDPSGGDVVGIAWAELSSGRFEAGVFPRARLDDELARIGPAEVLHCEDDASVHPDPTATWSWTARPAWSYAAADAEKSLCKQLSVANLEGLGFEDNGDVAIRAAGAVLCYLKETQRGSLDHFRSLTCHNRSPVLQIDAATRRSLEITRTMRTGSREGALLGVIDRTVTPMGSRMLADHLAAPLIDADAITYRTDAVDEFVRNNNLRSDIRTVLGDTYDLTRLLARVATGRTGPRDLRQIAVTLSGLPALKARLAERDSACLTRLESELHLCPELREQLESALNDECPLSAADGNFIREGFDSELDTLRELARGGKRWIAEYQQRQMDETGIANLKVGYNRVFGYYLEVSNAHKDKIPADFIRKQTLKNCERYITPELKEYEEKVLAADEKASSREQMLFTLLRENTHKHLAILQEVANAIAMTDVVASLAEVAAQHHWVRPTLTDDSVLRIEGGRHPVLDVTMAQGEFVPNDCIQSPETGMILLITGPNMAGKSTYIRQVALITLLAQTGSFVPATSAEIGIADRIFARVGASDELSRGQSTFMVEMVETARILNTATSRSLVILDEIGRGTSTYDGLSLAWAITEHLHEQIGARTLFATHYHELAALQETLPRVANLSVAVKEWQDEVVFLHRIVPGSADKSYGIQVARLAGIPVEVNERAKDVLAQLEADHRDSLDRPTIAPPSGVNGKGSGDTYQLTLFGYADHPLIQEIETVDIDSMSPIQAWQFLQEAKAKLSAGPKAVKG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: TPSCM_MENPI
Sequence: MATNGVVISCLREVRPPMTKHAPSMWTDTFSNFSLDDKEQQKRSETIEALKQEARGMLMAATTPLQQMTLIDTLERLGLAFHFETEVEYKIEQINAAAEDDGFDLFATALRFRLLRQHQRHVSCDVFDKFVDKDGKFEESLSNNVEGLLSLYEAAHVGFREERILQEAVNFTRHHLEGAELDQSPLLIREKVKRALEHPLHRDFPIVYARLFISIYEKDDSRDELLLKLSKVNFKFMQNLYKKELSQLSRWWNTWDLKSKLPYARDRVVEAYVWGVGYHYEPQYSYVRMGLAKGILIIGIMDDTYDNYATLNEAQLFTQVLDKWDRDEADRLPEYMKIVYEFILSTCENYERDAAKLGKSFAAPYFKETVKQLARAFNQEQKWVMERQLPSFQDYVKNSEKTSCIYTMFASIIPGLKSVTQETIDWIKSEPTLATSTGMIGRYWDDIGSHLRESKGGEMLTALDFHMKEYGLTKEEAASKFEGLVEETWKDINKEFIATTNYNVGREIAITFLNYARICEASYSKTDGDAYLDPNVAKANVVALFVDAIVF
What is the function of this protein?
Involved in the formation of muuroladienes.  Produces mainly cis-muurola-3,5-diene and cis-muurola- 4(14),5-diene, but also smaller amounts of gamma-cadinene and alpha-cadinene.
What are the official names of this protein?
Cis-muuroladiene synthase, MxpSS1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_SYNJA
Sequence: METAIEWITAHEILDSRGQPTLEALVGLANGATGLAQVPSGASTGTFEAHELRDGDPKRYGGKGVLRAVENILGPIQSELRGEDALNQARIDQLLIDLDGTPNKSQLGANAILAVSLATAKAAASAVGLPLYRYLGGPFANLLPAPLMNVLNGGAHADNNLDIQEFMIVPIGAPSFREALRYGAEVFAALKQVLRQRGLSTGVGDEGGFAPNLDSNAAALDLLMTAIEQAGYRPGEDIALALDVAANELLQDGQYHFEGKARSAEQMVNYYEQLLANYPILSLEDGLAEEDWAGWQAMTARLGSRVQLVGDDLFVTNPARLQKGIDSGAANAILIKLNQIGTLTETVSTIQLAVQAGFRTLISHRSGETEDTTIADLAVATRAGQIKTGSLCRSERIAKYNQLLRIEDELGEAAVYAGRVGLGPRGLPARSR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: MDH_ALKCK
Sequence: MAIKRRKISVIGSGFTGATTALMVAQKELGDVVLLDIPNMEGPTKGKALDMLESTPVQGVDSTITGTSSYEDTKDSDVVVITAGIARKPGMSRDDLVATNAKIMKSVTKEVVKYSPNSYIIVLTNPADAMTYTVYKESGFPKNRVIGQSGVLDTARFRTFVAQELNVSVEDVTGFVLGGHGDDMVPLIRYSAAGGVPLTKLIAPERIEEIVERTRKGGGEIVGLLGNGSAYYAPAASLTQMVEAILKDKKRIIPTIAYLEGEYGQHDLYLGVPTILGGDGIEKVIELDLTEEEKAQLDKSVQSVRNVMAALPAE
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: ARSK_CHICK
Sequence: MGSGGPLLLLRGLLLVGAAYCAAPRPPRHSSRPNVLLVACDSFDGRLTFYPGNQTVDLPFINFMKRHGSVFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPDYVTWMDLMQKHGYYTQKYGKLDYTSGHHSVSNRVEAWTRDVEFLLRQEGRPKVNLTGDRRHVRVMKTDWQVTDKAVTWIKKEAVNLTQPFALYLGLNLPHPYPSPYAGENFGSSTFLTSPYWLEKVKYEAIKIPTWTALSEMHPVDYYSSYTKNCTGEFTKQEVRRIRAFYYAMCAETDAMLGEIISALQDTDLLKKTIIMFTSDHGELAMEHRQFYKMSMYEGSSHVPLLVMGPGIRKQQQVSAVVSLVDIYPTMLDLARIPVLQNLSGYSLLPLLLEKAEDEVPRRGPRPSWVLSEFHGCNVNASTYMLRTDQWKYITYSDGVSVPPQLFDLSADPDELTNVAIKFPETVQSLDKILRSIVNYPKVSSTVQNYNKKQFISWKQSLGQNYSNVIANLRWHQDWLKEPKKYEDAIDRWLSQREQRK
What is the function of this protein?
Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity).  Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity).  Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity).
What are the official names of this protein?
Arylsulfatase K, ASK, Glucuronate-2-sulfatase.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Secreted. Lysosome.
Protein: RS3_ENCCU
Sequence: MSSDQVLERFMKNGLMNAELKEFFEKALVNEGFSTMELRMQETPIKIILKVAKPHEAIGEKKFRLRQFQHLAAQRLEVPDESVEIVVEKVHEKGLCALIQANFIREKILGGVQYRRAVNMALKTARHAKAQGCQIIVSGKLKGQRAKSVKFQDGVLIHSGDAVKDYINTGYATVETKQGVIGIQVRIMLPYDPEGVLGPNYPLPDRITILEPSEIQ
What are the official names of this protein?
40S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: Y728_KLEP3
Sequence: MNLQHHFLIAMPALQDPIFRRSVVYICEYNDEGAMGIIINKPLENLQVEGILEKLKIVPEPRNPEIRLDKPVMLGGPLAEDRGFILHTPPSDFSSSIRISDNTVVTTSRDVLETLGTDRQPGNVLVALGYSSWEKGQLEQEILDNAWLTAPADQNILFRTPIADRWREAAKLIGIDIVTMPGVAGHA
What are the official names of this protein?
UPF0301 protein KPK_0728.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: RS19_MYCCT
Sequence: MARSLKKGPFVDENLFKKVTSAKDGEVIKTWSRRSTIFPEFIGKTFGVYNGKEFIPVYITEDMVGNKLGEFAPTRKFGGHGDDKGKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: COX2_CANAU
Sequence: MAYPFQLGLQDATSPIMEELLHFHDHALMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETVWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTQELKPGELRLLEVDNRVVLPMEMTIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMAMRPGLYYGQCSEICGSNHSFMPIVLEMVPLSYFETWSALMV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: APOE_HETGA
Sequence: MKALWAVLVVTLLAGCRADVQPELEMQEPALWQSGQPWELALGRFWDYLRWVQTLSDQVQEELLNSQVTQELTVLMEDTMKEVKAYKNELEEELGPVAEDTKARLSKELQGAQARLRADMEEVRNRLAHYSEEMQVMLGQSPDELRARLGSHLRKLRKRLLRDAEDLQKRLAVYKAGAREGAERGVSAIRERLGSLVEQSRVRAALTGQPLRERAQAWGERLRGRLEEVGGRARDRLDEVREQMEEVRAKVEEQAEAFQARLKGWFEPMMEDMRRQWADLIEKVQLAVGASTPVPSEDH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: RS15_LEGPH
Sequence: MSLNSAEKAEIINEYKRGDKDTGSPEVQVSLITSRIKYLTDHFKENKKDFHSRRGLQELVNKRRKLLKYLKRNDQDRYQTLIQNLGLRDSY
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RL11_RHOE4
Sequence: MPPKKKKLAGLIKLQIQAGQANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGNVVPVEISVYEDRTFDFKLKTPPAAKLLLKAAGVAKGSGEPHKTKVASVTMDQVREIAKTKAEDLNANDIEQAAKIIAGTARSMGITVQG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.