PharMolix/UniProtQA huggingface dataset:
Protein: CARB_STRS7
Sequence: MAKRTDIKKIMVIGSGPIVIGQAAEFDYAGTQACLALKEEGYQVVLVNSNPATIMTDKEVADKVYIEPLTLAFVSRILRKERPDALLPTLGGQTGLNLAMELSKAGILQELGVELLGTPLSAIDQAEDRDLFKQLMKELGEPIPESEIVTTVEGAISFANAIGYPVIVRPAFTLGGTGGGICTNEEALRDIVENGLKLSPVTQCLIERSIAGFKEIEYEVMRDAADNALVVCSMENFDPVGIHTGDSIVFAPTQTLSDVENQLLRDASLRIIRALKIEGGCNVQLALDPNSFSYYVIEVNPRVSRSSALASKATGYPIAKIAAKIAVGLRLDDMLNPVTGTTYAMFEPALDYVVAKLPRFPFDKFEQGERRLGTQMKATGEVMAIGRRIEECLLKACRSLEIGVDHNELKGLDTVSDHELVAHIVRAQDDRLFYLSEALRRGYSIEELAGLTKIDLFFLDKLRHIVELEQELVKKPVDIDLLTEAKRYGFSDQKIAELWQTDAASIRRLRRAYRVLPVYKMVDTCAAEFDSQTPYFYSTYEWENESIKSEKESVIVLGSGPIRIGQGVEFDYATVHSVKAIQAAGYEAIIMNSNPETVSTDFSISDKLYFEPLTFEEVMNVIELEQPKGVILQFGGQTAINLAEQLTKAGVPILGTQLEDLDRAEDRKLFEKALKDLGIPQPPGKTATNEAEALEAARAIGFPVLVRPSYVLGGRAMEIVENEDDLRSYMKTAVKASPEHPVLIDSYILGKECEVDAISDGQSVLIPGIMEHIERAGVHSGDSMAVYPPQHLSKQVQDKIVDYTKRLAIGLNCIGMMNIQFVIQNEQVYVIEVNPRASRTVPFLSKVTNIPMAQVATKLILDQTLKDLGYQDGLYPESSLVHIKAPVFSFAKLAKVDSLLGPEMKSTGEVMGSDLTLEKALYKAFEASYLHMPEYGTIVFTIADDHKPEALALARRFSAIGYQVMATEGTAAFFADQGLDSQLVGKIGGNAHDIPALLRKGQIQAIINTVGAKRVADQDGQVIRSSAIEQGVPLFTALDTAAAMLRVLESRTFSIEAI
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: PILB_MYXXD
Sequence: MSGRLGELLVRENLISVQQLRKAQEEQQKNGTRIGTALVKTGAIEESKLTDFLSKQYGVPAINLKDFDVEPDIIKLVPKEVAEKHLVVPVNRAGPSLIVAMCDPSNIFAVDDLKFLTGYNIETVVASEVSIREAIERYYAEKGPSLEDIVGDVGDDIEVTKEETENIDEMAKAADDAPVVKLVNLILMDAIKKRASDIHVEPYEKDFRVRFRIDGVMYEVMRPPMKLRNAITSRLKIMASLDISERRLPQDGRIKIKMGGGKEMDFRVSVCPTLFGEKVVMRLLDKSNLQLDMTKLGFDAQPLAWFKEAIDRPYGMVLVTGPTGSGKTTTLYSALSSLNGLDTNICTAEDPVEFNFAGINQVQMHDDIGLNFAAALRSFLRQDPDIIMIGEIRDFETAEIGVKAALTGHLVLSTLHTNDAPGTVSRLLNMGIEPFLVTASLNLILAQRLARRLCPACKKPAENVDEQALIDAGVPPDKIGTFTMYEKVGCRDCNDRGYRGRVAIYEVMPFWDGLKELVINGASAAELKQEAIRLGMSSLRMSGLRKMMDGATTLEEVVGNTAPDRF
What is the function of this protein?
ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers.  Acts as a molecular motor to provide the energy that is required for biogenesis of the pilus and the extrusion of substrates generated in the cytoplasm (PubMed:28779124, PubMed:26965631).  PilB ATPase activity is also essential for T4P extension while antagonist PilT ATPase activity is required for T4P retraction (PubMed:18223089).  In addition, functions as a regulator of exopolysaccharide (EPS) downstream of the T4P filament and upstream of the Dif signaling (PubMed:28779124).
What are the official names of this protein?
Type IV pilus assembly ATPase PilB.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Displays polar localization.
Protein: ENGB_META1
Sequence: MWKFIKSATDQNNWLEHDQNEIVFWGRSNVGKSSLINALASQKIAKTSSTPGRTRLINYFETQRKKIIVDLPGYGFASMSKKAQSKISGIIDFYFRNSKNSKNICILIDAKIGFSYIDLEMIDYLKSLGLLFDIIITKIDKANQSQKHRVKQQALTFSDDINIFMVSSEKKQGLSDLVEHFEL
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: AROE_ECO8A
Sequence: METYAVFGNPIAHSKSPFIHQQFAQQLNIEHPYGRVLAPINDFINTLNAFFRAGGKGANVTVPFKEEAFARADELTERAALAGAVNTLKRLEDGRLLGDNTDGIGLLSDLERLSFIRPGLRILLIGAGGASRGVLLPLLSLDCAVTITNRTVSRAEELAKLFAHTGSIQALGMDELEGHEFDLIINATSSGISGDIPAIPSSLIHPGIYCYDMFYQKGKTPFLAWCEQRGSKRNADGLGMLVAQAAHAFLLWHGVLPDVEPVIKQLQEELSA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: FLIE_SALA4
Sequence: MAAIQGIEGVISQLQATAMAARGQDTHSQSTVSFAGQLHAALDRISDRQTAARVQAEKFTLGEPGIALNDVMADMQKASVSMQMGIQVRNKLVAAYQEVMSMQV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: IL8_SHEEP
Sequence: MTSKLAVALLAAFLLSAALCEAAVLSRMSTELRCQCIKTHSTPFHPKFIKELRVIESGPHCENSEIIVKLTNGKEVCLDPKEKWVQKVVQAFLKRAEKQDP
What is the function of this protein?
Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection.  Also plays an important role in neutrophil activation.  Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells.  G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
What are the official names of this protein?
Interleukin-8, IL-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPD_GEOUR
Sequence: MRVTALVPAAGMGKRMGADINKQYLLLEGKPILAHTLAVFELAPFVDDIYVITPEAEIPYCREHVVEQFGFTKVRGVVAGGKERQNSVLNGLRAIDASDEDDVVLIHDGVRPFIPTAVLKRSVEVATAEDGALVAVPAKDTIKTVEAGIVTGTPPRENIWLAQTPQTFRYGIIRAAHELAAAEGFLGTDDASLVERLGRQVHVVMGDYRNIKITTPEDMLLAEAFLKSVNSER
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: NUOK_PSEA7
Sequence: MNAIPLEHGLALASVLFALGLVGLMVRRNILFVLMSLEVMMNAAALAFVVAGSRWGQPDGQVMFILVLSLAAAEASIGLAILLQLYRRFHTLDIDAASEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: C14C1_ORYSJ
Sequence: MEKLLALIVVLVILLSLALFYLCNILWLRAVKIRKKLRRQGIRGPKPTFLYGNTKEIKRIRQELKFSQKQGTNNFISTLFPHFLLCRETYGPVFLYSTGALEILQVSHPDMVKDIGRWTPSELGKPNYLKKSRKALFGGGLFTENGDEWAYQRKIIAPEFFMDKIKGMIQLIEDATVTVLEAWEDMIDDVGGCREIVVDDYLRNLSADVIARACFGSSFTKGEEIFCKLRQLQKVIAQQDSFVGLSALWKYLPTKSNQEIQMLDEQVRLLILDVAKEQHHYQDSHNSLVNAIIDGAQDGRSAAEAEDFIVGNCKTIYFGGHESTAVTAIWCLMLLATHSEAMEVCRGRSTLDVDALRRLKIVTMVIQETLRLYPPASVMMQEALTDVKLGNIEVPRGTIVQVPRLMLHLDKEAWGADADEFRPDRFANGVAAACRAAHMYVPFGHGPRTCIGQNLAMAELKVVLARLLTKFAFSPSPRYRHSPAFRLTIEPGFGLPLMVTKLP
What is the function of this protein?
Probably not involved in gibberellin metabolism since over-expression of CYP714C1 in a heterologous system does not induce semi-dwarfism.
What are the official names of this protein?
Cytochrome P450 714C1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type III membrane protein.
Protein: SMC1_YEAST
Sequence: MGRLVGLELSNFKSYRGVTKVGFGESNFTSIIGPNGSGKSNMMDAISFVLGVRSNHLRSNILKDLIYRGVLNDENSDDYDNEGAASSNPQSAYVKAFYQKGNKLVELMRIISRNGDTSYKIDGKTVSYKDYSIFLENENILIKAKNFLVFQGDVEQIAAQSPVELSRMFEEVSGSIQYKKEYEELKEKIEKLSKSATESIKNRRRIHGELKTYKEGINKNEEYRKQLDKKNELQKFQALWQLYHLEQQKEELTDKLSALNSEISSLKGKINNEMKSLQRSKSSFVKESAVISKQKSKLDYIFKDKEKLVSDLRLIKVPQQAAGKRISHIEKRIESLQKDLQRQKTYVERFETQLKVVTRSKEAFEEEIKQSARNYDKFKLNENDLKTYNCLHEKYLTEGGSILEEKIAVLNNDKREIQEELERFNKRADISKRRITEELSITGEKLDTQLNDLRVSLNEKNALHTERLHELKKLQSDIESANNQEYDLNFKLRETLVKIDDLSANQRETMKERKLRENIAMLKRFFPGVKGLVHDLCHPKKEKYGLAVSTILGKNFDSVIVENLTVAQECIAFLKKQRAGTASFIPLDTIETELPTLSLPDSQDYILSINAIDYEPEYEKAMQYVCGDSIICNTLNIAKDLKWKKGIRGKLVTIEGALIHKAGLMTGGISGDANNRWDKEEYQSLMSLKDKLLIQIDELSNGQRSNSIRAREVENSVSLLNSDIANLRTQVTQQKRSLDENRLEIKYHNDLIEKEIQPKITELKKKLDDLENTKDNLVKEKEALQNNIFKEFTSKIGFTIKEYENHSGELMRQQSKELQQLQKQILTVENKLQFETDRLSTTQRRYEKAQKDLENAQVEMKSLEEQEYAIEMKIGSIESKLEEHKNHLDELQKKFVTKQSELNSSEDILEDMNSNLQVLKRERDGIKEDIEKFDLERVTALKNCKISNINIPISSETTIDDLPISSTDNEAITISNSIDINYKGLPKKYKENNTDSARKELEQKIHEVEEILNELQPNARALERYDEAEGRFEVINNETEQLKAEEKKILNQFLKIKKKRKELFEKTFDYVSDHLDAIYRELTKNPNSNVELAGGNASLTIEDEDEPFNAGIKYHATPPLKRFKDMEYLSGGEKTVAALALLFAINSYQPSPFFVLDEVDAALDITNVQRIAAYIRRHRNPDLQFIVISLKNTMFEKSDALVGVYRQQQENSSKIITLDLSNYAE
What is the function of this protein?
Involved in chromosome cohesion during cell cycle and in DNA repair.  Central component of cohesin complex.  The cohesin complex is required for the cohesion of sister chromatids after DNA replication.  The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped.  At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
What are the official names of this protein?
Structural maintenance of chromosomes protein 1, DA-box protein SMC1.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. At anaphase, the MCD1 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Protein: Y3522_CELJU
Sequence: MSISKWPASERPREKLLSMGAPALSDAELLAIFLRIGCVGKSAVDVARELLQQFGGLRPLLEASQKEFCRGRGLGMVKYVQLQAVLEMARRHIHADMKVGDLLSSPHLVRDYLRAQLRHHAREVFAVLFLDNQNRLIAYEELFQGTIDGANVYPREVVKQALAHNAAAVIFAHNHPSGLAEPSQADIRITRRLQEALGLVDIRVLDHLVVGDGELVSLAERGWL
What are the official names of this protein?
UPF0758 protein CJA_3522.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: CARB_STAA9
Sequence: MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEIADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTELTSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGGICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRFPFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYIKERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLEYLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTYETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVSTDFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLENLNRAEDRKEFEALLRKINVPQPQGKSATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIVDNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHSGDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRTVPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITLGPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQRLNEVGYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGFQIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: ACCD_MARN8
Sequence: MSNWLDKIMPSKIRSESRQRTGVPEGLWKKCPKCGAFLYKPELEKNLDVCPKCNHHLRVSARRRLDIFLDKDGREELAAHLEPSDRLKFKDSKRYKDRLAAAQKSTGEKDALIAMRGTTMGVPLVACAFEFNFLGGSMGQVVGEKFVQAANVALEHRIPLVCFSASGGARMQEAILSLMQMAKTAAVLEKLKQEGIPYISVMTDPVFGGVSASLAMLGDLNIAEPYALIGFAGPRVIEQTVREKLPEGFQRSEFLLEHGAIDMILHRHQMRERIAHLLAKFTAQEKPGTEAPIEFEVTEKPDVDEPEGQ
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_VIBCM
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVARVAEVIDIPFCVAGGIKSAQDAARILEFGADKVSINSPALANPQLITDLADRFGVQCIVVGIDSYFDKETGQYQVYQFTGDESRTRATQWQTCDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLNLVRSVCRVPLIASGGAGAMEHFAQAFTQANVDGALAASVFHKQIINIGELKQYLKQQGIEVRR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNY_STRPC
Sequence: MVNIILLIVSALIGLILGYALISIRLKSAKEAAELTLLNAEQEAVDIRGKAEVDAEHIKKTAKRESKANRKELLLEAKEEARKYREEIEQEFKSERQELKQLETRLAERSLTLDRKDENLSSKEKVLDSKEQSLTDKSKHIDERQLQVEKLEEEKKAELEKVAAMTIAEAREVILMETENKLTHEIATRIRDAERDIKDRTVKTAKDLLAQAMQRLAGEYVTEQTITSVHLPDDNMKGRIIGREGRNIRTLESLTGIDVIIDDTPEVVILSGFDPIRREIARMTLESLIADGRIHPARIEELVEKNRLEMDNRIREYGEAAAYEIGAPNLHPDLIKIMGRLQFRTSFGQNVLRHSVEVGKLAGILAGELGENVALARRAGFLHDMGKAIDREVEGSHVEIGMEFARKYKEHPVVVNTIASHHGDVEPDSVIAVLVAAADALSSARPGARNESMENYIKRLRDLEEIATSFDGVQNSFALQAGREIRIMVQPEKISDDQVVILSHKVREKIENNLDYPGNIKVTVIREMRAVDYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: CLC3A_MOUSE
Sequence: MAKNGLVLCILVVSLLLDQTDGYPSRMKARKHSKRRVKAKDDDLKSQVEKLWREVNALKEMQALQTVCLRGTKVHKKCYLASEGLKHYHEANEDCISKGGTLVVPRNSDEINALRDYGKRSLPGVNDFWLGINDMVTEGKFLDVHGFAVSFLNWDRAQPSGGKRENCVLFSQSAQGKWSDEACRSSKRYICEFIIP
What is the function of this protein?
Promotes cell adhesion to laminin and fibronectin.
What are the official names of this protein?
C-type lectin domain family 3 member A, C-type lectin superfamily member 1, Cartilage-derived C-type lectin.
What are the subcellular locations of this protein?
Secreted.
Protein: FUCM_SALPA
Sequence: MLKTISPLISPTLLKVLAEMGHGDEIIFSDAHFPAHSLGPQVIRADGLSVSDLLRAIIPLFELDSYAPPLVMMAAVEGDTLDPSVEARYRDALSLEAPCPDIVRIDRYAFYERAQKAFAIVITGECAKYGNILLKKGVTP
What is the function of this protein?
Involved in the anomeric conversion of L-fucose.
What are the official names of this protein?
L-fucose mutarotase, Fucose 1-epimerase, Type-2 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. FucU mutarotase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC117_HUMAN
Sequence: MAALGRPFSGLPLSGGSDFLQPPQPAFPGRAFPPGADGAELAPRPGPRAVPSSPAGSAARGRVSVHCKKKHKREEEEDDDCPVRKKRITEAELCAGPNDWILCAHQDVEGHGVNPSVSGLSIPGILDVICEEMDQTTGEPQCEVARRKLQEIEDRIIDEDEEVEADRNVNHLPSLVLSDTMKTGLKREFDEVFTKKMIESMSRPSMELVLWKPLPELLSDKPKPSSNTKNYTGESQAKHVAAGTAFPQRTELFSEPRPTGMSLYNSLETATSTEEEMEL
What is the function of this protein?
Facilitates DNA repair, cell cycle progression, and cell proliferation through its interaction with CIAO2B.
What are the official names of this protein?
Coiled-coil domain-containing protein 117.
Protein: Y574_METTH
Sequence: MILENFKRESLIPLPVTFISTTSKDGIRNIAPYSCVMPVLRPFDLICVASAKMRDTVVNIKDTGEFVINMPGVEMVDKVIPTASHVPFDVNEFELADLKERPSKKVKAPGIEGCYAWMECKLHNIYEDEYEGFPYLLILGKVVHLEVNDDIYNPEDGSWDIEKANPLMMVESDRGMHFCTVSDINKFEPYGAMFPDGKDPLAWMYEKRETRE
What are the official names of this protein?
Uncharacterized protein MTH_574.
What is the protein family that this protein belongs to?
Belongs to the flavoredoxin family.
Protein: TRMN6_SALG2
Sequence: MSQSGSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVADVKRILDIGTGSGLLALMLAQRTDDNVPIDAVELDAGAAMQAQENVAHSPWPHRITVHTDDIQSWAPRQTVRFDLIISNPPYYEPGVECATPQREQARYTATLDHQTLLAIAADCITEDGFFCVVLPEQIGNAFTQQALNMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGSDQHYSESYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_CHRVO
Sequence: MQHPFHSYPAPAKLNLLLHVVGKRPDGYHLLETVFRFIDFGDTLELAVRDDGQIVLLTPTDGVPPEQDLTVRAARLLQRESGCRLGASIKLEKRTPMGGGLGGGSSDAATALIALNRLWGLAWPRERLQALGLQLGADVPVFIFGRNALATGVGEVLEPIPLKPAWYLVIHPQVHVSTIEVFRNFSQTVLTEIGRVGIMRILETTQQRRNDLQSVVEKRFPAVNEVLSELRKYGSPLMTGSGSCVFLEFESKDEADKVYRVLSQKYQGFVAEGLDVHPLFDSAE
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RUVA_LISIN
Sequence: MYDYIKGIVKTITPEYIVVETGQIGYQIITGNPFSFQRLEGTEAQVFLYQHVREDNISLFGFQSTEERYLFKKLLSVSGIGPKSALAIIASGDVVPLITAIESEDDVYLTKFPSVGKKTARQIILDLKGKLADVVASEIVYKAAENDIVTGLSPQLEEAVLALEALGYSTRELKKVIPKMAKENDLTSDAYIKLALRLMTK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: MCES_CRYNB
Sequence: MVYDPIRDCDVPAPHISAPPLSRSRSPPPPHRTPSASGSLRGLLNDSPPPREPPRAASVHEDAESHRPKLSNILNDAEPPRQRSMLPPQQPIHAELEHGRRTSAGSHAAQLARSPSMSLSPRSQNQSLPYPSSRPGSAAGSAHPFGYDPRQGTLSPVLSARRTSEDQPRPTSSSSASGRRYTEPASQTPAPAPLGSSAYRPRHTSTPGNPSSAYAPRFTPQPTTTPSSPSTSQHTPYTPHHSAPPRILHYNPHRQSAPSSVLRPIYPDEVAHLRQLAHANNPLRQKPAARRYSYSGGRAPEPTPTPRTSLPGENDHSYFPPQWDDRPSMPPSEVSYGGPPSSTPGAPPSGYSQYPPNWEAQTPGGNWNGERPGRLGKRRARDEEDDEYERNKRVVSGPVAGQAYSKKVTVVAEHYNSRPEVGVERREFSPIIGLKKFNNWIKSVLIGKFAYRPRGKVLDVGCGKGGDLNKWKQARIALYVGLDVADQSVQQAADRYRRMPKPGFDAFFYAHDCFSNPLSDVLSPELQIKDLYDNVTMQFCMHYAFENAAKARMMIENVSRYLRRGGIFIGTIPNAELLLQLPDRDEELRFGNSCYSIQFTERRHKGVYGHDYRFYLTDAVEDVPEYLVDWENFVSLASESGLRLVYKKAFHEILQEEKDSRDFGPLLGKMGVLNEYGESAMDADQWEAANLYMGFAFEKM
What is the function of this protein?
Responsible for methylating the 5'-cap structure of mRNAs.
What are the official names of this protein?
mRNA cap guanine-N7 methyltransferase, mRNA (guanine-N(7))-methyltransferase, mRNA cap methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: JADE3_MOUSE
Sequence: MKRHRPVSSSESSDECPSTSFTSSSMYRKKSKNPKEQKKSAEVFRKDLISAMKIPDSHHVNPDSYYLFTDTWKEEWEKGVQVPANPDSVPTPSLRIISEKVKEMLFVRPRKYIRCSSPESAEPGYINTLEQAASTCRYDLDDMDIFWLQELNEDLGEMGYGPIDETLMEKTIEVLERHCHENMNHAIETVEGLGIEYDEDVICDVCRSPDSEEGNDMVFCDKCNVCVHQACYGILKIPEGSWLCRSCVLGIYPQCVLCPKKGGAMKTTRTGTKWAHVSCALWIPEVSIACPERMEPVTKISHIPPSRWALVCNLCKLKTGACIQCSVKSCITAFHVTCAFEHGLEMKTILDEGDEVKFKSFCLKHSQNKPKLGDAEYHHHRVAEQSQAKSEKTSLRAQKLRELEEEFYTLVQVEDVAKEMELSAFTVDFIYNYWKLKRKSNFNKPLIPPKEEEENGLVQPKEESIHTRMRMFMHLRQDLERVRNLCYMISRREKLKLSHTKVQEQIFGLQVQLINEEITEGLSLTNALENSLFYPPPRITLKLKMPKSTSEDCKDSSTETEHQLSSPGSSSPGHSKRSPQMPEEPLDMNVKIYPRYPLESKSNCLQTSRSHSRCETKSSSPTPRAPSAEFYHGQSLGKPLALQAALHGQVSIGNGKNQPNSRVSSSNGLEGNWSGNITQKVNSSEVCYDQESMLSSHLPSPGNIRKSSMEHFSRSFKEATNTWVKPTEDLQYCVKPTKNVSSKEQLWGRQLLRRPTGRASYQETDGYCPDLEPSDSEAEGEGSKETPRVKRESSDRENPSHDSARECHGKTKTHPHSHSSMQR
What is the function of this protein?
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity.
What are the official names of this protein?
Protein Jade-3, Jade family PHD finger protein 3, PHD finger protein 16.
What is the protein family that this protein belongs to?
Belongs to the JADE family.
Protein: PEX4_ARATH
Sequence: MQASRARLFKEYKEVQREKVADPDIQLICDDTNIFKWTALIKGPSETPYEGGVFQLAFSVPEPYPLQPPQVRFLTKIFHPNVHFKTGEICLDILKNAWSPAWTLQSVCRAIIALMAHPEPDSPLNCDSGNLLRSGDVRGFNSMAQMYTRLAAMPKKG
What is the function of this protein?
Required for peroxisome biogenesis.  Necessary for the developmental elimination of obsolete peroxisome matrix proteins.  May be involved in the ubiquitination of PEX5, targeting it for recycling.  Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
What are the official names of this protein?
Protein PEROXIN-4, AtPEX4, E2 ubiquitin-conjugating enzyme 21, Probable ubiquitin-conjugating enzyme E2 21, Ubiquitin carrier protein 21.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Peroxisome membrane; Peripheral membrane protein.
Protein: SPESP_BOVIN
Sequence: MKFLVLLVALLLWPSSLPAYRRVTVTPDEEQNLNHYVQVLQNLILSVPTKEPGRQKKSKSPNNANFIGPRVSRVKELKYTHDVGPGDNDVLINPVSEETTTFPTRGFTLEIDKKKRTKSTAFWSIKPSNVSVVLHAKEPFIEKDEPEPEPEPEPEPEPVEHRTGAPTQVPSVTEPSQDVTSLSGSTDLGTATEEEDVPQLSGDNEMDYLESHDMYNEDVLKRIADINSQLHHVPLPESYKPEYRADIRASKEHLKRSLALAIAAEHKLEKMYKSQMLPQGRSSGGVYDIITVINMLYNSRYKLSEYLDIKYVPLEMRGKATVVVHTLKRILCVGHGEETHNLLKQLLNNNIRILHILDTHDKDDSS
What is the function of this protein?
Involved in fertilization ability of sperm.
What are the official names of this protein?
Sperm equatorial segment protein 1.
What is the protein family that this protein belongs to?
Belongs to the SPESP1 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (By similarity). After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity).