PharMolix/UniProtQA huggingface dataset:
Protein: PPID_BOVIN
Sequence: MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKEGLLSMANAGSNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVAKILENVEVKGEKPAKLCVIAECGELKEGDDWGIFPKDGSGDSHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKEKAAYAKMFA
What is the function of this protein?
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.  Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes.  Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control.  May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes.  May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus.  May regulate MYB by inhibiting its DNA-binding activity.  Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity.  Involved in regulation of UV radiation-induced apoptosis.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase D, PPIase D, 40 kDa peptidyl-prolyl cis-trans isomerase, Cyclophilin-40, CYP-40, Cyclophilin-related protein, Estrogen receptor-binding cyclophilin, Rotamase D.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: MNMG_SALHS
Sequence: MFYQDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVSRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASQHPQQVPCYITHTNEKTHDVIRNNLDRSPMYAGVIEGIGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFIHGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEMGRELGLVDDERWARFNEKLENIERERQRLKSTWVTPSAESADEVNAHLTTPLSREASGEDLLRRPEMTYAQLTSLAAFAPALEDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQGMLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_ERWT9
Sequence: MSRVAKAPVVIPAGVEVKLDGQVISIKGKNGELTRTLNNAVEVKHADNTLTFAPREGFADGWAQAGTSRALLNAMVIGVTEGFTKKLQLVGVGYRAAVKGNAVSLALGFSHPVEHALPAGITAECPTQTEIVLKGADKQLIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: DAPE_TERTT
Sequence: MSPTLQLACDLISRASVTPEDAGCQALMTERLRAIGFHIESLRFDDVDNFWAVRGASGPILCFAGHTDVVPEGDPAKWQSPPYEPTITDGLLYGRGAADMKGSLAAMVTACEAFVAEHPNHTGRIAFLITSDEEGIAANGTVKVVEWLEARGEKVTWCLVGEPSSTQSVGDVIKNGRRGSLGCKLTVKGKQGHVAYPHLAKNPIHLVAPALADLAAEQWDEGNDFFPATSFQVSNFNAGTGATNVIPGEAAIVFNFRFSTESTADELKQRTEAILAKHGLDYDIHWHLSGEPFLTPAGALVDAAVTAIRAECGAEPELSTSGGTSDGRFIAPTGAQVLELGPVNATIHQINECVNVADLDKLSATYQRILKELLA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: KRB2_VACCA
Sequence: MESFKYCFDNDGKKWIIGNTLYSGNSILYKVRKNFTSSFYNYVMKIDHKSHKPLLSEIRFYISVLDPLTIDNWTRERGIKYLAIPDLYGIGETDDYMFFVIKNLGRVFAPKDTESVFEACVTMINTLEFIHSRGFTHGKIEPRNILIRNKRLSLIDYSRTNKLYKSGNSHIDYNEDMITSGNINYMCVDNHLGATVSKRGDLEMLGYCMIEWFGGKLPWKNESSIKVIKQKKEYKKFIATFFEDCFPEGNEPLELVRYIELVYTLDYSQTPNYDRLRRLFIQD
What is the function of this protein?
Pseudokinase that plays a role in viral DNA replication repression by activating the antiviral protein BANF1 and inhibiting the activity of host VRK1, a cellular modulator of BANF1.
What are the official names of this protein?
Pseudokinase OPG198.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Poxviruses subfamily.
What are the subcellular locations of this protein?
Host nucleus.
Protein: NUOH_SALTY
Sequence: MSWITPDLIEILLSILKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLSFAIVPVSPNWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTVSYEVFLGLSLMGVVAQAGSFNMTDIVNNQAHLWNVIPQFFGFVTFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTVSALMVTLFFGGWHGPFLPPFVWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKVCLPLTLINLLVTAAVILWQAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YFD2_YEAST
Sequence: MRVVRQSGSALSRAKKSRKYTSYRVMNVVLNTLFSFVLAPYIHYILEEISPQWTTREMNTEICFLAKFSFLLVFLFYLNFQGFNSVSNITTSSSPTYDNNRHYGND
What are the official names of this protein?
Putative uncharacterized protein YFL032W.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IBPA_ECOK1
Sequence: MRNFDLSPLYRSAIGFDRLFNHLENNQSQSNGGYPPYNVELVDENHYRIAIAVAGFAESELEITAQDNLLVVKGAHADEQKERTYLYQGIAERNFERKFQLAENIHVRGANLVNGLLYIDLERVIPEAKKPRRIEIN
What is the function of this protein?
Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpA, 16 kDa heat shock protein A.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_ECOHS
Sequence: MSDISKASLPKAIFLMGPTASGKTALAIELRKILPVELISVDSALIYKGMDIGTAKPNAEELLAAPHRLLDIRDPSQAYSAADFRRDALAEMADITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEQQAAEQGWESLHRQLQEVDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYLEGEISYDEMVYRGVCATRQLAKRQITWLRGWEGVHWLDSEKPEQARDEVLQVVGAIAG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: MAUL_METFK
Sequence: MLRNRTDAVHDRVRFSIGTRVMSSWSIVVWMFHRQTWQFLLTTGFILCISSIAWSAEVHQMELTHHEFEPWSFVPKPGDRIDIHNHSDIVHAIYVTYPNGIVVNLSETAAQLPGMTVSWTVPEDAEDGDEYVLQCWIHTIIRAALKVKAPLSQLPEP
What is the function of this protein?
Probably involved in TTQ prosthetic group biosynthesis.
What are the official names of this protein?
Methylamine utilization protein MauL.
Protein: PCDH8_MOUSE
Sequence: MSPAKRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGPSPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQASYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFGARTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGPGPRTATCKVIVRIRDVNDNAPEISITPLAAPGAPATSPFAAAAAAAALGGADAASSTGSGTQEAGITSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGTPPLRTVRPYTVRVGDENDNAPIFTKPVYEVSVRENNPPGAYLATVAARDPDVGRNGQVTYRLVEAEVGRSGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQASDGGSPQLSSNALVQVRVLDQNDHSPILVHPAPANGSLEVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEPPGRVFKALLVISDGGRPPLTTTATVSFVVTAGGGSAVPASSGSPEHSRPPGSRLAPSGPSLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPDETARGTGPRPNMFDVLTFPGSGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCAGPNVHPPPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYESPPGSRYVSPKKGINENV
What is the function of this protein?
Calcium-dependent cell-adhesion protein (By similarity).  May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity).  Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway (By similarity).  In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis.
What are the official names of this protein?
Protocadherin-8, Arcadlin, Paraxial protocadherin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Presynaptic cell membrane. Postsynaptic cell membrane. Note=Expressed in neuronal cell bodies and dendrites. Localized to excitatory, but not with inhibitory, synapses.
Protein: CCA_LACJO
Sequence: MKINNLPEVFTAALPVLKEINEAGYEAYFVGGSVRDLLLNRHIHDVDIATSAYPMEIKQIFKKTIDTGIKHGTVTVLYEGESYEITTFRTESGYQDFRRPDHVTFVQNLSEDLKRRDFTINALAMDVDGNIIDHFDGLGDLEKHLIRAVGKAENRFHEDALRMMRAVRFMSQLQFTLEPETEQAISDNHELLSKISVERIRDEFVKMGIAPGSQKAFQIFLDTGLSEEVPGFRGKKENLALYPQLNFSPTTEANLWALMIILLKLPNDKIPHFMRMWKNSNAMERQVADIVAFFDLISSHAPNNYDLYKAGLETIVSTIDLAHILGQPVNGSALVDSYEALPIKNNRDLVIDGHFLLKNGIPAGPRVGLLLEEIKKAVLEGVISNNEAAITEFISLNH
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: VPAP_HCMVA
Sequence: MDRKTRLSEPPTLALRLKPYKTAIQQLRSVIRALKENTTVTFLPTPSLILQTVRSHCVSKITFNSSCLYITDKSFQPKTINNSTPLLGNFMYLTSSKDLTKFYVQDISDLSAKISMCAPDFNMEFSSACVHGQDIVRESENSAVHVDLDFGVVADLLKWIGPHTRVKRNVKKAPCPTGTVQILVHAGPPAIKFILTNGSELEFTANNRVSFHGVKNMRINVQLKNFYQTLLNCAVTKLPCTLRIVTEHDTLLYVASRNGLFAVENFLTEEPFQRGDPFDKNYVGNSGKSRGGGGGGGSLSSLANAGGLHDDGPGLDNDLMNEPMGLGGLGGGGGGGGKKHDRGGGGGSGTRKMSSGGGGGDHDHGLSSKEKYEQHKITSYLTSKGGSGGGGGGGGGGLDRNSGNYFNDAKEESDSEDSVTFEFVPNTKKQKCG
What is the function of this protein?
Accessory subunit of the DNA polymerase that plays an essential role in viral DNA replication and acts by increasing the processivity of polymerization (PubMed:20538862, PubMed:20739543, PubMed:33967989).  Forms dimers that binds to double-stranded DNA and UL54 specifically to stimulates long chain DNA synthesis efficiently.  Plays an important role in maintaining the structure of viral replication compartments by interacting with host nucleolin/NUC (PubMed:22318319).  In addition, suppresses innate immune responses through effects on host IRF3 and NF-kappa-B.  Mechanistically, interfere with the binding of IRF3 and the p65 NF-kappa-B subunit to the promoters of antiviral genes, thereby inhibiting the expression of these genes (PubMed:30867312).
What are the official names of this protein?
DNA polymerase processivity factor, Polymerase accessory protein, PAP, Protein ICP36.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae polymerase accessory protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: IPT_DICDI
Sequence: MKILLIIGSTGVGKTDLSINYSKKYNAPVVVLDRIQCFPELSITSGRPDESEYFGSKRIYLTDLLVEPGNENIKKTFYVNKLINILNEIKNNYDTQNLPNEKGYGCIFEGGSISLLKELLTKINKLPYKITCVIYIRPSDSIDNHKLYKAKIFKRVSQMLFPTEEGNDSQILEVKRILNKGKTVNAQGEINLEYYEKIKQVLISLVGLVGIEDVIHFLDKQYDQKNITSKLDPNYLNEIQSQLIETITLAHYNYALSQIELIDSLIKQLPKSIEYCLKNIEIN
What is the function of this protein?
Transfers dimethylallyl groups to AMP as part of the biosynthesis of cytokinin phytohormones like isopentenyl adenine or discadenine which controle spore formation and viability.
What are the official names of this protein?
Adenylate dimethylallyltransferase, Isopentenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the isopentenyl transferase family.
Protein: RBM8A_XENTR
Sequence: MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGADEGTRARIREDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFGEFGEIKNIHLNLDRRTGFLKGYALVEYETYKEALAAMEGLNGQDLMGQPISVDWGFVRGPPKGKRRSGRRRSRSPERRRR
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome (By similarity).  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs.  Associates preferentially with mRNAs produced by splicing.  Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs.  Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity).
What are the official names of this protein?
RNA-binding protein 8A, RNA-binding motif protein 8A, Ribonucleoprotein RBM8A.
What is the protein family that this protein belongs to?
Belongs to the RBM8A family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: AROC_NEIMB
Sequence: MAGNTFGQLFTVTTFGESHGAGLGCIIDGCPPGLELSEADIQFDLDRRKPGTSRHVTQRREADQVEILSGVFEGKTTGTPIALLIRNTDQRSKDYGNIATSFRPGHADYTYWHKYGTRDYRGGGRSSARETAARVAAGAVAKKWLKEKFGTEITAYVTQVGEKEIRFEGCEHISQNPFFAANHSQIAELENYMDSVRKSLDSVGAKLHIEAANVPVGLGEPVFDRLDAEIAYAMMGINAVKGVEIGAGFDSVTQRGSEHGDELTPQGFLSNHSGGILGGISTGQDIRVNIAIKPTSSIATPRRSIDINGNPIELATHGRHDPCVGLRSAPIAEAMLALVLIDHALRHRAQNADVQVNTPDITLSNK
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: NRDR_STRPF
Sequence: MRCPKCNYHKSSVVDSRQAEDGNTIRRRRECEQCHTRFTTFERVEELPLLVIKKDGTREQFSRDKILNGVVQSAQKRPVSSTDIENVISRIEQEVRTTYENEVSSTAIGNLVMDELAELDEITYVRFASVYKSFKDVDEIEELLQQITNRVRGKKKRLNNDETN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: DNLJ_AQUAE
Sequence: MFTPEREKELQEKTRELLRKIKDVKVLSFEEAKKLAEDLREVIRYHDYKYYVEANPVIPDYDYDRLFRALKEIEKKYPELITPDSPTQRVASEISGEFPTVKHYTPMLSLDNAYSEDELREFDRRVRQITGLEVVEYAVEPKLDGAGIALVYENDLFVRGATRGDGEYGEDITNNLKTIKTIPLKAEFSRFGIKLAEIRGEVVIRKDEFQKLNKERMEEGLPPFANPRNAAAGSIRQKDPKEVAKRNLEAIVYHLSYVEPPETEPPTHYESLKMLHTLGFKTLFKDTKVCKGIDEVIEYCKEWEKKRDSYPYEIDGMVVKVNDRRLWKVLGYTSHHPRWAIAYKFKPRRAVTKLVDVVFQVGRTGTITPVGKLEPVELGGVTVSSVSLFNEDFIREKDIRIGDWVVVERAGDVIPYVVEVLKEKRTGEEKPVEFPKYCPSCGSELVKLPEEVAIRCINISCPAQSVLRIKHWASRDAMDIRGLGDATIKLLFNRGLAKDVGDLYYLKLTDILKLPGFGEKSAMNLLKAIEESKNRPLDRVLYGLGIRYVGQTTAKKIAEIINSVWDLKDIPLEKLMRLEGIGYKVARSIKEFFNIPQNLEVLKKLEKAGVNLAKKVKEKVADVLKGKTFVFTGTLDCCSREKAGEIVEMLGGKFSNSVTSKTDYLVVGKDPGATKLSKAKKYGVKTITEEEFVNMIKDYVDLEKIKKEDKKEKPKIGRLF
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: DCTA_XANCB
Sequence: MHISKPAGPLPAPVPFYRQLYFQVVVAIVLGALLGHFEPAFAESLKPLGDAFIKLVKMIIAPVIFLTIVTGIAGMTHLKTVGRVFAKSMTYFLFFSTLALIVGMVVAHVVQPGAGMNINPAELDQSAVNTYVQKSHELSLVGFLMDIIPATLISAFVDGNILQVLFVAVLFGIALALVGERGRPVLSFLEALTAPVFRLVHMLMKAAPIGAFGAIAFTIGKYGVESLVNLAWLVGSFYLTSLFFVLVILGIVCRLCGFSVLKLIRYLKAELLLVLGTSSSESALPSLMEKMEKAGCEKSVVGLVVPTGYSFNLDGTNIYMTLAALFIAQATNVDLTLGQQITLLAVAMLSSKGAAGVTGAGFITLAATLSVVPDVPVAGMALILGVDRFMSECRSLTNFIGNAVATVVVSRWENALDRDQLSLALDGRAPPLQAPVPPPDAVAPVSAR
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BTUFA_HALS3
Sequence: MHRGRFATLVIVALAVTMTAPAGALAPQPPAQHADADRACSFPVTEPDASNTAITLDSEPERVVTLNPSAAQTMWELGDRDAVVGVSQFGTYLPTASQRTVVSGGQPSQTNVEAVVGLDPDLVLAPNTVRNTTVTRLRSAGITVFQFRAATSIDGVVEKTATIGRLTGNCAAAAATTAEMRDRVAAIADAVPDTDSARPRVYYHLGDGYTAGPNTFIGAAIEAAGGHNIAADVNTTSSYPQLSEEVIVSQDPDVVVTGVSADRLDATASALVAPSSVVRNTTAYATGNVVAVNTNHINQPAPRIVEPMARMANAFHNTTINTTLDAQPSATTTATSTAPPTDAADGTAPGFGVAAAVCALAGAALVARR
What is the function of this protein?
Required for corrinoid utilization.  Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import.  Probably binds cobalamin and delivers it to the surface of BtuC (By similarity).
What are the official names of this protein?
Cobalamin-binding protein, Vitamin B12-binding protein.
Protein: RL10_STAA3
Sequence: MSAIIEAKKQLVDEIAEVLSNSVSTVIVDYRGLTVAEVTDLRSQLREAGVEYKVYKNTMVRRAAEKAGIEGLDEFLTGPTAIATSSEDAVAAAKVISGFAKDHEALEIKSGVMEGNVITAEEVKTVGSLPSHDGLVSMLLSVLQAPVRNFAYAVKAIGEQKEENAE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: TIG_CERSK
Sequence: MQVTETQKEGLKRAYTITVTAAELDAKVQEKLVEAQPDIEMKGFRKGKVPLAMLKKQFGPRLLGDAMQDAIDGAMRDHLETSGDRPAMQPEVRMVDGETWKEGTDVVVEMKYEALPEIPEIETSKVSLERLVVKADEAAIEEALKNLAESAQNFEDRRKGSKAKDGDQVVIDFKGSVDGELFEGGSAEDYPLVLGSGSFIPGFEEQLVGTKVDDEVTVKVTFPAEYGAKHLAGKEAEFACTVKAVKAPKAAELDDELAKKYGAEDLAALKGQISERLEAEYKGASRAVLKRALLDQLDQMVSFELPSKLVEAEAHQIAHQLWHEEHPEEHGHNHGNIEPTDEHKALAERRVRLGLLLAEIGRKAEVTVTDAEMTQAVLAQARQYPGQERAYFEFVQKNPQIQQQLRAPIFEDKVVDLILEGATVTEKEVGKDDLQKAIEALDEM
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: YLOH_SCHPO
Sequence: MDYKQRIEKFKDILNSEEPISLPGLCSLCIQGIPDEYSLRAKAWMLMLEFLPTDRSNWQSVLEKHRKTYTSFVQELLIDPWRKLTLHEESGENSDHPLNTSDDSKWKEYFDDNQILEQIDKDIRRTLPDLSFFQGKSEINKKPSVNNVSENISVNTEDDKVEEVGQKLNYTKITSIDQSQETPVHLSTIDFSKFQEECHLVLQGRIYRLENESTSSSTTALSTPRQSMDSKRTINAEAIAGENKLGLHREAAERILFIYAKLNPGIGYVQGMNEILAPLYYVLATDPTYENYYLCECDAFFLFTQMMVQVRDLYEKTLDHDSDHGIHFLMSKFTERLKKYDYELWENLEEKQIHPTYYSFRWFTCLLSQEFPLPDVIRLWDSIIADQMKARLFGKNDDGFNGAYDFLMDFCCSILIELRESILERNFADSIKLLQAHFNVDMPKLLNLTFELQHLRKTSKNDEDMSYVRKNSYNTNALANSLKNRVLSTYNTVKANVPQSSSSYTDNNKQKEPLEEKRSFFPSFRSSLDGVSPTQGRKSGEENIRTIFAKPTAHIGENGWSNLKVKGSSIFQRFGNFVGDTMRYITEEEESSEEEDLTTSRRKIGITSKRKVSVKRNVI
What is the function of this protein?
May act as a GTPase-activating protein for Rab family protein(s).
What are the official names of this protein?
TBC domain-containing protein C1952.17c.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_SHEPA
Sequence: MSKVVVCAMYKFVTLAEFEKLQSPLQKVMETSGVKGSLLLAQEGINGTVAGSQSAIDNLLAWLATQPGLDNIVYKLSFDDVMPFYRTKVKLKKEIVTMGVEGIDPKKVVGTYVKPKDWNQLISDPEVLLVDTRNDYEVQIGTFKDALDPKTKTFREFPDYVKQNLDPAKHKKVAMFCTGGIRCEKSTAYLKEQGFDEVFHLEGGILKYLEEVKLEESLWQGECFVFDNRVAVDHNLEKGQYAQCNACRMPITADEMALDSFVQGVSCLHCIDNISEKQRQRFIERERQVQLSKLRGEAHIGSDVSQVIQTRRAKKDRLKKAQHDKSA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.