PharMolix/UniProtQA huggingface dataset:
Protein: FMDB_METME
Sequence: MPLYEYECDSCGVFTALRKMSESSLPAECDCCGAVSPRILSVPKLAIMDKLQRSAHERNEKSANEPRTARRSSCGCTGSHTCKTKPPVNQDTGKPGLQMQTKKTARPWMVGH
What is the function of this protein?
May be a positive regulator of formamidase.
What are the official names of this protein?
Putative regulatory protein FmdB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OMP2B_BRUME
Sequence: MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTEICLRVHGYVRYDVKGGDDVYSGTDRNGWDKGARFALRVSTGSETELGTLKTFTELRFNYAANNSGVDGKYGNETSSGTVMEFAYIQLGGLRVGIDESEFHTFTGYLGDVINDDVISAGSYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTGTTNYHIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWAAKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTVTPEVSYTKFGGEWKNTVAEDNAWGGIVRFQRSF
What is the function of this protein?
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
What are the official names of this protein?
Porin Omp2b.
What is the protein family that this protein belongs to?
Belongs to the alphaproteobacteria porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: SPS18_YEAST
Sequence: MRLFENSKDMENRKRLLRAKKAAGNNNCFECKSVNPQFVSCSFGIFICVNCANLLRGMGTNIFCVKSITMDNFEEKDVRRVEKSGNNRFGSFLSKNGILQNGIPLREKYDNLFAKSYKRRLANEVRSNDINRNMYLGFNNFQQYTNGATSQIRDRTLREISNNSNASEGAEFVLPEKVLGSDNFQDCERFPACLSSERNLDENNVTSATSTLTIEKFQNDPIGTISRSWQLLSDALYKSYEDFKGSVVQPTIENIQQRNLPNDIKRSFVHFNEKLHETPHLPSPVFSCFTGGDILPPEFN
What are the official names of this protein?
Sporulation protein SPS18, Sporulation-specific protein SPX18.
Protein: T2R40_PANTR
Sequence: MATVNTDATDKDISKFKVTFTLVVSGIECITGILGSGFITAIYGAEWARGKTLPTGDRIMLMLSFSRLSLQIWMMLENIFSLLFRIVYNQNSVYILFKVITVFLNHSNLWFAAWLKVFYCLRIANFNHPLFFLMKRKIIVLMPWLLRLSVLVSLSFSFPLSRDVFNVYVNSSIPIPSSNSTEKKYFSETNMVNLVFFYNMGIFVPLIMFILAATLLILSLKRHTLHMGSNATGSRDPSMKAHIGAIKATSYFLILYIFNAIALFLSMSNIFDTYSSWNILCKIIMAAYPAGHSVQLILGNPGLRRAWKRFQHQVPLYLKGQTL
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 40, T2R40.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: OLM2A_PIG
Sequence: MTAAAVPLRPGPGPLPLLLLPLLLLRAGPVRADSKVFGDVDQVRMTSEGSDCRCKCIMRPLSKDACSRVRSGRARVEDFYTVETVSSGTDCRCSCTAPPSSLNPCENEWKMEKLKKQAPELLKLQSMVDLLEGTLYSMDLMKVHAYVHKLASQMNTLEESIKANLSRENEVVRESMRHFSEQLKHYENHSAIMMSIKKELSSLGLQLLQKDAASVPGAPPATGPGSKAQDTAGGKGKDSNKHGSVQKTFVDKGLPRPPKEKLLKAEKLKKEGGKARFPQPTAKPRALAQQQAVIRGITYYKAGRKEMTEAMADNALKGTSWLEQLPPRVEGRLPEPNSAERDEAGGPRASEAADLAPGTPASGPTLTPTPTASPLPTEPPSRPEVPSPGREASCEGTLRAVDPPVRHHSYGRHEGAWMKDPAAKDDKIYVTNYYYGNSLVEFRNLENFKQGRWSNMYKLPYNWIGTGHVVYQGAFYNRAFTKNIIKYDLRQRFVASWALLPDVVYEDTTPWKWRGHSDIDFAVDESGLWVIYPAADDRDEAQPEVIVLSRLDPGDLSVHRETTWKTRLRRNSYGNCFLVCGILYAVDTYNQREGHVAYAFDTHTGADARLQLPFLNEHAYTTQIDYNPKERVLYAWDNGHQLTYTLHFVV
What are the official names of this protein?
Olfactomedin-like protein 2A.
What are the subcellular locations of this protein?
Secreted.
Protein: CPES_MICDP
Sequence: METKVLMNITKFVANSIGHWRSQRSAHHLAFGHFEAVQSEIDIIALPHDDPAVIDLCKSYNIDPQTVVSPFRMTWEGQSDWDDSEIKGTCVLVPIPDPDSPHRGKLLRSRLCRNNRCRGDYYFTEHGTFVLVTAYERAAAEEKIWFVNPNVRCLCVSLIKTSVRFSELLLPHFLQKFARIFRIKLYMTIFKSYRYKLRACSLYINAIALALPCHFFINTGA
What is the function of this protein?
Covalently attaches a chromophore, probably phycoerythrobilin, to Cys residue(s) of phycobiliproteins.
What are the official names of this protein?
Putative phycoerythrobilin lyase CpeS.
What is the protein family that this protein belongs to?
Belongs to the CpcS/CpeS biliprotein lyase family.
Protein: ARAA_YERPE
Sequence: MDVFKQSEVWFVIGSQNLYGPKTLQQVMDNAHQVVNSLNNEAGLPVKLVLKPLVTTPDEITALCREANYDTACIGIMTWLHTFSPAKMWIGGLSILNKPLLQFHTQFNAQIPWKTMDMDFMNLNQTAHGGREFGFIGARMRQQHSVITGHWQDKEAHQRIGQWMRVAAAKQESQQLKVARFGDNMREVAVTEGDKVAAQIQFGYSVNAYGIGDLVAVVDAVSKGDIDTLVEEYEATYRFTDAVKLNGDKRENLLDAARIELGMTRFLEQGGFKAFTTNFENLYGLKQLPGLAVQRLMQQGYGFGGEGDWKTAALLRILKVMGTGLKGGTSFMEDYTYNFQPGNDLVVGSHMLEVCPSIAKEEKPLLDVQHLGIGGKADPARLIFSTPAGPALNASLIDMGNRFRLLVNVVDTVEQPHPLPKLPVARAIWQAQPSLATAAEAWIIAGGAHHTVFSQAVGVDELRLYAEMHGIEFLLIDNDTTLPAFKNEIRWNEVYYQLNR
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: ORAI_CAEEL
Sequence: MPRSHDPSRVELLRKEGGLTEKRVSISVEDIRGAVANWKNSGGAGDPITPYPLPQFFLQPPSTAGGGSRNGVGSKEGSVTSLRMPLKKAGDDVDLGHRGELDLSEKYNYDLSRAQLKASSRTSALLAGFAMVCLVELQYDQSTPKPLLIVLGVVTSLLVSVHLLALMMSTCILPYMEATGCTQDSPHIKLKFYIDLSWLFSTCIGLLLFLVEIGVIFYVKFTAVGYPTAGYITTAMLVPVGVVFVVFSYLIHKNRVSHSLGRFKHKVDTMKQFLDVEANLQKSTLAPSTIRDI
What is the function of this protein?
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim-1.  Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca.  Affects brood size and somatic cell function.
What are the official names of this protein?
Protein orai, Store-operated calcium channel.
What is the protein family that this protein belongs to?
Belongs to the Orai family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PAG55_SHEEP
Sequence: RGSXLTILPLRNMRDIVY
What are the official names of this protein?
Pregnancy-associated glycoprotein 55, ovPAG-55.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DAD2_CANGA
Sequence: MDGLEQQKLAKQQELAALKRITALTDQMRTELDEMSIEVSKINKNAESVANVMANWDSIRKYISEASLGLLRYAEGDYQVGAWDGKENKSDKSNADKSYQSDDEHKTEPLPEALVRISVANNEESRK
What is the function of this protein?
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
What are the official names of this protein?
DASH complex subunit DAD2, Outer kinetochore protein DAD2.
What is the protein family that this protein belongs to?
Belongs to the DASH complex DAD2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Protein: MOCO1_CULQU
Sequence: MEFVQEYSDEEAAAIEREFTRLKDKHYLDHGGATLYAESQIQAVHDLLTANMFGNPHTSHQTGQLMDEVRRRVLRFFNTDSSEYSLIFTSGATASLKMVAENFTFRAADSAEGDEGAFVYLRDNHTSVLGMRAIVGTSRIHPLERENFVRHLKVSARSSQRKPSLVVFPAQNNFNAAKYPLELIEEIRENGLVGYDDDKFYVCLDVASFVSTNFLDLDRYKPDFVCMSFYKIFGYPTGLGALLIRKGSEDLLDKKYYGGGTIQIVMSGKNLHRKHVKPSDCFEDGTQPFLSIIALLEGFNTIQRLIPPSNGYRSMERVSKHVFNLAKYCYHQLGELVHANGAKVIHFYMDSRFESRDRQGGIVTFNVLKDDGSYVGYAEFARIALKHAVYLRAGCFCNSGTCQRQLKLSDEGLLEYFKMGKICGDDNDMIDGHPTGTVRAAFGYMTKPENVDRLVEMIRERFVSQGISRPVKPTNRSSNDEELELKAIYIYPIRSCGSFTVTTSWPMVDRGLKHDREFSIVNSNGTPLSQSKHTDMASIVPKIDPRSNVLILTHPTMPDLILNLNKLPTAKSTILPEDSVDCGDEIAAWISKALRQPRLRLAKHLNDGNHSPPPKILMINGNALRSLGDEDSAEDQATASWLVEHFQGNLVVEAPATVDMQTWKQVAIGEHRFKVVGMCTRCPMIYVDPASGKVSADSLKAIANVFKKKVPLGMYLAYVGDGGATARSLQCGGRFILEQKDHSKVTSITESVVRFNFNG
What is the function of this protein?
Sulfurates the molybdenum cofactor.  Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
What are the official names of this protein?
Molybdenum cofactor sulfurase 1, MCS 1, MOS 1, MoCo sulfurase 1, Molybdenum cofactor sulfurtransferase 1, Protein maroon-like 1, Ma-l 1.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
Protein: THN2_VISAL
Sequence: KSCCPNTTGRNIYNTCRFGGGSREVCASLSGCKIISASTCPSYPDK
What is the function of this protein?
Thionins are small plant proteins which are toxic to animal cells.  They seem to exert their toxic effect at the level of the cell membrane.  Their precise function is not known.
What are the official names of this protein?
Viscotoxin-A2.
What is the protein family that this protein belongs to?
Belongs to the plant thionin (TC 1.C.44) family.
What are the subcellular locations of this protein?
Secreted.
Protein: JMY_XENTR
Sequence: MSFNLEDTLESDWVAVRPNVFEEKERRKFVFIVAWNEVEGKFAITCHNRTAQRQRSADKAGGRSPARQQQRDSPAQSPARKAREEPEEGEEEECSWAGLFSFQDLRAVHQQLCSVSSELEPCLPTFPEEPSGVWSVLFGPSELSEAEVEDLGRQLRLYLGHALDTSGWKILSQVLFADSDDPEEYYQSLSELRHKGYEEGLQRARKRLQELLEKHKTTEVMVDLLDLYQLEDEAYSNVVEATTELYQYLLQPFRDMRELAMLRRQQIKISIENDYLGPRRIESLKKEDADWQKKAHMAVLSIQDLTVKYFEITARAQKAVFDRMRGDQKKFGKTAWAAAVERVEKLQYGVAKETLQLMRAKEICLEQKKHALKDQMQSLQGGTEAIAVLDELEADYYDHQLQLYEVQFEILKCEELLLTAQLESIKRQISEKTDEVVYYDTYESMEAMLATEDMAASIHIQRVELQKLQQKVRQLEAKRGRISAKKAYLRNKKEICIAKHSEKIQQRLHSDEGYRAAQLKQEKQEDEEERKSTWVSQERQKTLDRLRTFKQRHPGQVVLKSTRLRFSHERRRSTIRTTSSTDAPQSLSVSIQTQGLSDLGDTEVLQPIKTQKPETTTQLEDSSLPPNAITSELPLMTSLPTFTHEKLEPEISTLQPSSLPASPPPPPPPLPPPPPPPLPPSKQDTDTLEIRVIHVKKETEEKDGAKPVSGPLAQLFDSSQLLNARKTLKKTGALEGIQRRRVSSPMDEVLASLKRGSFHLKKVEQRALPPFPDEDESNNILAQIRKGVKLKKVQKEALRESFTLLPDTDPLTRSIHEALRRIKEASPESEDEEESLPCTDWEN
What is the function of this protein?
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions.  In nucleus, acts as a cofactor that increases p53/TP53 response.  Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage.  In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments.  Activates the Arp2/3 complex to induce branched actin filament networks.  Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments.  Contributes to cell motility by controlling actin dynamics.
What are the official names of this protein?
Junction-mediating and -regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the JMY family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane. Note=Localizes to the nucleus in most cell types. In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus (By similarity).
Protein: Y521_ACIC5
Sequence: MSGHSKWATIKHKKGALDAKRGKIFTRLIKEITISARAGGDPDGNPRLRTAIAAAKAENMPQDNIKRAIQRGTGELPGAVYEEITFEGYGPGGVAVIVEATTDNRNRAVSEIRHAFSKNGGNLGEPNSVRFMFQKKGLIVVSKDAADEEKLMNIVLEAGGDDLNGEGENWEILTEPQAYDAVVQAVRDAGIEPQVAEVTMIASTYTKLEGATANQMMRLLETLEDHDDVQNVYSNFDMEQVEEVAG
What are the official names of this protein?
Probable transcriptional regulatory protein ACP_0521.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_ALTMD
Sequence: MKATELKDKSVEELNAELINLLREQFNLRMQHTTGQLEKTDQLRKVRRNIARVKTILTQKADA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: ASCL2_RAT
Sequence: MESHFNWYGVPRLQKASDACPRESCSSALPEAREGANVHFPPHPVPREHFSCGAPKPVAGAPALNASLMDGGALPRLVPTSSGVAGACTARRRPPSPELLRCSRRRRSGATEASSSSAAVARRNERERNRVKLVNLGFQALRQHVPHGGANKKLSKVETLRSAVEYIRALQRLLAEHDAVRAALSGGLLTPATRPSDVCTQPSASPASASLSCTSTSPDRLGCSEPASPRSAYSSEDSSCEGETYPMGQMFDFSNWLGGY
What is the function of this protein?
AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
What are the official names of this protein?
Achaete-scute homolog 2, Mash2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPB7_SOYBN
Sequence: MFFHIVLERNMQLHPRYFGRNLRDNLVSKLMKDVEGTCSGRHGFVVAVTGIENIGKGLIRDGTGFVTFPVKYQCVVFRPFKGEILEAVVTMVNKMGFFAEAGPVQIFVSNHLIPDDMEFQSGDMPNYTTSDGSVKIQKDSEVRLKIIGTRVDATEIFCIGTIKDDFLGVINDPATV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element.  The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft.  The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB7, RNA polymerase II subunit B7.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSPL8_SORBI
Sequence: MGLRDSLKEREDRRSSEEEGDARQSWMTRESTTGWRKESTAALGTPVADWQCVLLLQFGALQQKLLKAFPRAGPRPTTTLVPARPERARKKPHSQPPPSTHMALQAQATASPSPSPSPTRGRTGSGEWPDDAEKLPIAATASPARSSDAVELVVVASTRHAAAAKYVPRRSTSHTADPNPGRGGGGGSAGWYSWNGGRTRTAAPPRHARADPPPAPPRRQQPVEAPPPPPPPPPPPAPAPALPPPVPPSPPAPAQAPVPPSATAPAPAPVPAPRASSPHVQFRSADQVVPNILSRKRRAAAMQRTALLARGAAAGLCLAALAVLAADTRKGWARDSYSNYTQFRYSEAVNVIGFIYSVFQFVALVELMRRNKHLIPHPKRDLFDFTMDQVLTYLLISSSSSATARVSDLIDNWGSDPFPSMANGSIAISFLAFAVFAICSLISAYNLFRRDV
What are the official names of this protein?
CASP-like protein 4A1, SbCASPL4A1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ETS1B_XENLA
Sequence: EFSEPSFITESYQTLHPISSEELLSLKYESDYPLGLLRDPLQPESLQGDYFTIKQEVVSPDNMCLGRISRGKLGGQESFESIESHDSCDRLTQSWSSQSSYNSLQRVPSYDSFDSEDYPPALPSHKSKGTFKDYVRDRAELNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYVPEELHAMLDVKPDTDE
What is the function of this protein?
Transcription factor.  Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts.
What are the official names of this protein?
Protein c-ets-1-B, C-ets-1B, XE1-B.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: XEND_XENSI
Sequence: MSLIPSSIRLLRLLPALSSTSVLMFALDEHLIFGTWMHPTLRERANTTLPPWWTKGGLRWRWVIIIGYPLTYLLGILNLLVARDELQATGSTLWYTTGLLFSIAHMAYVGTALNWIANIENGMPKGNVTYSMGNWLKMNWTRALITDLPAWVCFITAALKVL
What is the function of this protein?
Epoxidase, part of the gene cluster that mediates the biosynthesis of xenoacremones such as xenoacremone A, a compound that shows inhibitory activity toward the PI3K/AKT signaling pathway and which has the ability to induce apoptosis of A549 lung cancer cells (PubMed:34900544).  Within the pathway, cooperation of the hybrid PKS-NRPS xenE and the trans-acting enoyl reductase xenG is responsible for the formation of the reduced tyrosine-nonaketide derivative (PubMed:34900544).  The alpha/beta hydrolase xenA then accelerates intramolecular nucleophilic attack to give a pyrrolidone derivative (PubMed:34900544).  Subsequently, three enzymes, xenF, xenD, and xenC, coordinately participate in the conversion to xenoacremone B (PubMed:34900544).  XenF catalyzes sigmatropic rearrangement to form an A-ring, which leads to an unusual intermediate with a hexane ring, which is required for the formation of the tricarbocyclic product (PubMed:34900544).  Epoxidation catalyzed by xenD and the formation of the paracyclophane ether catalyzed by xenC initiate a spontaneous intramolecular Diels-Alder (IMDA) reaction to yield xenoacremone B (PubMed:34900544).  Spontaneous hydration of xenoacremone B leads to the formation of xenoacremone A, which undergoes subsequent methylation to afford xenoacremone C (PubMed:34900544).
What are the official names of this protein?
Epoxidase xenD, Xenoacremones biosynthesis cluster protein D.
Protein: MC5R_MOUSE
Sequence: MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  This receptor is a possible mediator of the immunomodulation properties of melanocortins.
What are the official names of this protein?
Melanocortin receptor 5, MC5-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDXT_MYCSJ
Sequence: MNAVPDGRSDKPRSVVGVLALQGDTREHLAALTEAGAEAVTVRRLRELEAVDALVIPGGESTAMSHLLREFELLEPLRARLAEGMPAYGSCAGMILLATEILDAGAAGREATPLKGIDMSVRRNAFGRQVDSFEGDIPFVGLDSSVHAVFIRAPWVERIGDGVEVLARADGHIVAVRQGRMLATAFHPEVTGDRRVHKLFVDMVSE
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: Y1806_NATTJ
Sequence: MISQDLINRINELYKKQKESGLTDEEQQEQQKLRQEYLKGIRKQVLKQMGEDPEKEPKNN
What are the official names of this protein?
UPF0291 protein Nther_1806.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_CLOAB
Sequence: MNSKMEKLEKNVIKFEITVDESKFNEAVIKSYNKNRRRFNVPGFRKGKAPLNIIKNYYGVGVLYEDAINFCIDDTYPEVIKENDIHPVAYPEIDIVTLEEGKDFVYTAKVTVKPEVELGEYKGVEVTKVEYPVTDEDVENELKGMQEKNARIELKEDGEAVEKGDIAVIDFKGYVDDVAFEGGEGKDYSLEIGSGTFIDNFEDQLVGLKKDESKDVNVKFPEEYGKEELNGKPAKFEVTIKEIKRKELPALDDEFAKEVSEFDTLDEVKADIRSKMEKANEEKAKIEFEDKVVDAAVENAKIEIPEVMVKNETDQMLKELESRLRYQGLDLKSYYEYTNSSEEKVRDYMKETADKRVRTKLVMEKISEVEKVEATEEELKEKAKEMAQQYTNKDLDKMAELVLNSQRSMIEQDVINGKVIDLLVENAKVVE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: IF11_BURP1
Sequence: MAKEELIELDGIVDEVLPDSRYRVTLDNGVVVGAYASGQMRRHRIRILAGDRVTLELSVYDLTKGRINFRHKDERRSDAAPRASARRR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1 1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT28_SCHPO
Sequence: MRLFEGAFQPWKLASTNLMQQCLLLNKKSQFHTTCILQGLKKQKANQRRKQNLKRREELRKQNLDTLADPIIGHSSEWIARLLKPYEILVERKKPNFPIRSIKFPASMETINLIVEKFEKIRASATEETKDFIKLNEVNEFPSSDTSLESNQDGFERLHPLAERLERMSQLSDLRKESIHRIFNIENSNSKTLRLNNKQLAVESFARNERDTGSPEVQAAVYTSRILALSDHCKNHKKDQTGKRMLRYYVHQRQRMLKYLRKVNFDRYVHCIKNLGLTDELVLREVTQ
What is the function of this protein?
Essential component of the small mitochondrial ribosomal subunit.
What are the official names of this protein?
Probable 37S ribosomal protein S28, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HGPRT_STRMU
Sequence: MLEQNIKKVLYSEEEIIVKTKELGAQLTKDYAGKNPLLVGVLKGSVPFMAELMKHIDTHIEIDFMVVSSYHGGTTSSGEVKILKDVDTNIENRDVIFIEDIIDTGRTLKYLRDMFKYRQANSVRIATLFDKPEGRVVDIDADYVCYKVPNEFIVGFGLDYAENYRNLPYVGVLKEDVYSK
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.
What are the official names of this protein?
Hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNB_PSESM
Sequence: MSREQLSQEIIEAGRFLYGRGWSPATSSNYSVRLSASEALLTVSGKHKGQLGPDDVLATDLAGNSLEPGKKPSAETLLHTQLYLCRPQVGAVLHTHSVNATVLSRLTASDHLVFEDYELQKAFNGVLTHESQVVVPIFDNDQDIARLAANVQPWLDAHPECAGYLIRGHGLYTWGARMSDALRQIEAFEFLFECELKMRTVMNR
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.