PharMolix/UniProtQA huggingface dataset:
Protein: TRUB_PSYIN
Sequence: MARRGKGRSINGIILLDKPTDISSNHALQRVKRIFFANKAGHTGALDPLATGMLPVCLGEATKFSQFLLDSDKRYIVTATLGVRTTTSDSQGDVVSERPVEVTQTQLDQALDTFRGDIMQVPSMFSALKHKGQPLYKYAREGITIEREARPITVYEINQLRFEGNEVELDIHVSKGTYIRTIVDDLGELLGCGAHVSVLRRTQVADYPYDKMVTIEQLEALIEQAKESDVSPYDLLDPLLLDMDTAVKKYPEVNISDEMGEYVLHGQPVQVFGAPDNTVLRITVGEAHTFIGVGKMNEAGLIAPTRLANL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: Y949_SULTO
Sequence: MTKIIIEVEVRPSEDENKVLQAIRNLFDFENLKEEKSGYTKILVAESHTLLSLQKFHRKLREERILDAARKYLTKNLIGNVITFMLNKQAAAVGKISFVDDEKESPLGPIKVTIEYKDPQALIDWLTPKTAKGVPLWENPIPSDE
What are the official names of this protein?
UPF0201 protein STK_09490.
What is the protein family that this protein belongs to?
Belongs to the UPF0201 family.
Protein: RL25_SHEB8
Sequence: MSYTIQAQTRTEIGKGSSRRLRHAGKVPAVIYGQGKEPVSIVFDHKDIINIQANADFYTSTLTIVVDGKEVGVRAQAMQRHVFKPLIEHVDFVYA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: ATPD_MESFL
Sequence: MVLKDNVIDNWANALTKIAVKENKVKKMLEQAHVLIEVLKNKNEFVDILTFKSAHDEEKRIKIIDDTFSQFNIDEDIMNAFKILVHMQAFVNARDILKKLRGKLVELDNMTYGVVWSTEEISAAQIKEIEEKMSKKINKEVKLVNKIDTKLIAGIQVVVHNKVYDGSLRSKLDEMKYQVLKEK
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YBEY_ACIC1
Sequence: MTVEIANESGVDVDELRLLDLARYVLDRMRIHPLAELSILLVDEGEMAVLHERWMDEPGPTDVLSFPMDELRPGRLDVEIDPDAEPAVLGDVVLCPAVAKQQARHAGHSTQDELELLTVHGILHLLGYDHAEEDAEREMFALQSELLTAWRADRRIAGRPGRKR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_BACCR
Sequence: MQAKAVARTVRIAPRKVRLVVDLIRGKQVGEAIAILNHTPKTASPVVEKVLKSAIANAEHNYEMDINNLVVEKVFVDEGPTLKRFRPRAMGRASQINKRTSHITVVVSEKKEG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: SCPE_ARTBC
Sequence: MHVAILLAIISLARAAPSTKGYTVATSLPGKSAFETRRLPDAPEILKNWAGRLDIPGTTIGNSLFFWLFSAEDKAYDDNLIIWLNGGPGCSSLVGAFLENGPLRFMGNSTMPERNPYSWAKLGHVLYIDQPVGTGFASEKVPVTSNKEVISNLYSWLMSFDAIFDHILRTKKVHIVGESYAGIYIPYIASEIVKRKSELPVNLVSIAIGDGTIGPNTGMSSLGMVGFLEEYASKLRIPRDIMNAISFGDHACGFDIIRQRAKVYPPRGPFHLPGRSGSANNTEISNMLQKGVADESLGSCNIHPDTPEKIRSSIVNSTCYGHCAVFETTADYMSSQQCFSIYNINYGCNFTNPTSTLEAYFSRSDVQIALNLMHPTDPLRPFQSCNPKILETLMAPANRPVPPSFEILPDLLTTHKLPVHIYQGRLDMLINHVGIEVTIQNMTWNGAQGFQDSLHFEFGRQKDKAVGLWNEERGLSYHLFFEGGHFLPADLPMEVLSYVKEVVLRQ
What is the function of this protein?
Involved in degradation of small peptides.
What are the official names of this protein?
Carboxypeptidase Y homolog ARB_06361, Serine carboxypeptidase ARB_01587.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LEXA_LEPBL
Sequence: MKDLTDKQQAVLAFITTIIKERGFPPTIREIGDEFGITAKGAYDHLKAIEKKGYLKTAKNQSRAIELIRQSPMESIPVQATSIPVIGRVAAGLPIFADENIESYIPVPDEMAKGNVPMYALRVQGDSMIEVGIDSGDIAIIEKRDIARNGEIVVALIEDEATLKVYYKEQDQIRLEARNPKYKPIKTKKATVIGKLVGLYRIY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: DAPF_MYCTO
Sequence: MIFAKGHGTQNDFVLLPDVDAELVLTAARVAALCDRRKGLGADGVLRVTTAGAAQAVGVLDSLPEGVRVTDWYMDYRNADGSAAQMCGNGVRVFAHYLRASGLEVRDEFVVGSLAGPRPVTCHHVEAAYADVSVDMGKANRLGAGEAVVGGRRFHGLAVDVGNPHLACVDSQLTVDGLAALDVGAPVSFDGAQFPDGVNVEVLTAPVDGAVWMRVHERGVGETRSCGTGTVAAAVAALAAVGSPTGTLTVHVPGGEVVVTVTDATSFLRGPSVLVARGDLADDWWNAMG
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPZ2A_ORYSJ
Sequence: MEDNAGDCGGMTAFALRLAKRLADVGVSSNKNLVFSPASLYAALALVAAGARGTTLDELLALLGAASLDDLEESVRRAVEVGLADESASGGPRVSDACGVWHDETLELKPAYRAAAAGTYKAVTRAANFQRQPKRSRKKINKWVSKATNKLIPEILPDGSVHVDTALVLVNAIYFKGKWSNPFPRSSTTTGKFHRLDGSSVDVPFMSSREDQYIGFHDGFTVLKLPYHHRTMKNHGDGGDTITNSSITRAILEHYGGENVGLSMYIFLPDERDGLPALVDKMAASSSSSSFLRDHRPTRRREVGDLRVPRFKVSFYSQINGVLQGMGVTAAFDAGEADLSGMAEGVDQRGGGLVVEEVFHRAVVEVNEEGTEAAASTACTIRLLSMSYPEDFVADHPFAFFVVEETSGAVLFAGHVLDPTSSSE
What is the function of this protein?
Probable serine protease inhibitor.
What are the official names of this protein?
Serpin-Z2A, OrysaZ2a.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
Protein: LRC20_MOUSE
Sequence: MLRKMGEAVARVARKVNETVESGSDTLDLADCKLVSFPICIYKVLRNVSDQIHLITLANNELKSLTSKFMTTFNQLRELRLEGNYLFRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPLSADVRVIAPPLIKFDMLMSPEDTRAPPP
What are the official names of this protein?
Leucine-rich repeat-containing protein 20.
Protein: RL35_MYCFE
Sequence: MPKMKTKSALKKRIKITGTGKIMREQAYRSHLSQNKTTKQKRQARKSVQMHSSDVKRFKALI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: CDK2_ENTH1
Sequence: MTRYEKKQQLGEGTYGVVCKAWDTVCNRYVALKKIKQEREDDGIPVTSVREIAVLLELKHPNVVDLYDIYLEDKFLYLVFEFCDEDLYQFMSRSSKIPINETRSIVYQILQGLAFCHYHQILHRDMKPQNILINKNGTIKLGDFGLARLTTINDRKYTSEVVTLWYRAPEILLGATQYGGAIDIWSTAAIFGELINKEELFKGRCKIDQLFKIFSQLGTPTEDIWNGVTKLPFYLSTFPKWKAKDLHTIFHTDERAVDLLQKMFIYTPEKRISAADALKHPFFDPLNKPNN
What is the function of this protein?
Serine/threonine-protein kinase involved in the control of the cell cycle.
What are the official names of this protein?
Cyclin-dependent kinase 2, Cell division protein kinase 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: M300_ARATH
Sequence: MRKGERMLATSKEWERPRPVEASCSEGVLKVLKGCRTILKGNRHDSLYILQGSVETGESNLAETAKDETRLWHSRLAHMSQRGMELLVKKGFLDSSKVSSLKFCEDCIYGKTHRVNFSTGQHTTKNPLDYVHSDLWGAPSVPLSF
What are the official names of this protein?
Uncharacterized mitochondrial protein AtMg00300, ORF1451, ORF145a.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y1036_PECCP
Sequence: MPSFDIVSEIDMQEVRNAVENATRELSTRWDFRNVPASFELNEKSQSIKATSESDFQVQQLIDIMREKLLKRGIEGGALEVPEEFEHSGKTYSVEAKLKQGIETTQAKKIVKLIKDSKLKVQAQIQGEQVRVTGKSRDDLQGVMALIRGGNLGQPFQFTNFRD
What are the official names of this protein?
UPF0234 protein PC1_1036.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: LAFU_ECO44
Sequence: MRKTGNRRERGAKTTIVRRQIKKNHAGHHGGAWKVAFADFTLAMMALFMTLWIVNSVSKSERESIIAALHGQSIFNGGGLSPLNKISPSHPPKPATVAAPEETEKKARDVNEKTALLKKKSATELGELATSINTIARDAHMEANLEMEIVPQGLRVLIKDDQNRNMFERGSAQIMPFFKTLLVELAPVFDSLDNKIIITGHTDAMAYKNNIYNNWNLSGDRALSARRVLEEAGMPEDKVMQVSAMADQMLLDAKNPQSAGNRRIEIMVLTKSASDTLYQYFGQHGDKVVQPLVQKLDKQQVHSQRTR
What is the function of this protein?
Part of the flagellar gene cluster Flag-2.  However, the Flag-2 flagellar system could be inactive in strain 042 due to a frameshift in lfgC.
What are the official names of this protein?
Putative flagellar export/assembly protein LafU.
What is the protein family that this protein belongs to?
Belongs to the MotB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DAPA_SULDN
Sequence: MDIVTGSTTALITPFKNGKLDESAYANLIKRQINNGINAVCPVGTTGESATLSYAEDKRCIEIAVEICRGTATKVLAGAGSNSTSEAIEAAITAQKCGVDAIFSVAPYYVKPSQEGLYQHYKAIAESVSDMPFMLYNVPGRTVVDISADTVIRLFDDVKNIYGIKEATGSLERTVELLSRRPELKVFSGDDAIDYPILANGGAGITSVTSNLLPDLKSELVKKALNGDFTGSKAINDMLFPINKALFIESNPIMIKAAMYIAGLIDTLEYRLPLVAPSVENMKKIESVMKNYEIKGL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF6_METAC
Sequence: MIRTVDIYDTSIIGVFATCTEDVVLVPPLTKPEVCALLEEVLDVRVIETLVNGSIVVGALSRGNSNGFMLPYGARAEMQRFTDIPVGILPDRLNAVGNIVFANDSAALVHPDLSDKALEAIARTLKVDVYRGTIAGIKNVGMAGVVTNKGLLVHPKVTASEREVLEKIFGFPVNIGTTNFGTQMLGSGLLANSKNFVAGSETTGPELGRIEEALGFLE
What is the function of this protein?
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
What are the official names of this protein?
Translation initiation factor 6, aIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
Protein: AGO6_ARATH
Sequence: METSSSLPLSPISIEPEQPSHRDYDITTRRGVGTTGNPIELCTNHFNVSVRQPDVVFYQYTVSITTENGDAVDGTGISRKLMDQLFKTYSSDLDGKRLAYDGEKTLYTVGPLPQNEFDFLVIVEGSFSKRDCGVSDGGSSSGTCKRSKRSFLPRSYKVQIHYAAEIPLKTVLGTQRGAYTPDKSAQDALRVLDIVLRQQAAERGCLLVRQAFFHSDGHPMKVGGGVIGIRGLHSSFRPTHGGLSLNIDVSTTMILEPGPVIEFLKANQSVETPRQIDWIKAAKMLKHMRVKATHRNMEFKIIGLSSKPCNQQLFSMKIKDGEREVPIREITVYDYFKQTYTEPISSAYFPCLDVGKPDRPNYLPLEFCNLVSLQRYTKPLSGRQRVLLVESSRQKPLERIKTLNDAMHTYCYDKDPFLAGCGISIEKEMTQVEGRVLKPPMLKFGKNEDFQPCNGRWNFNNKMLLEPRAIKSWAIVNFSFPCDSSHISRELISCGMRKGIEIDRPFALVEEDPQYKKAGPVERVEKMIATMKLKFPDPPHFILCILPERKTSDIYGPWKKICLTEEGIHTQCICPIKISDQYLTNVLLKINSKLGGINSLLGIEYSYNIPLINKIPTLILGMDVSHGPPGRADVPSVAAVVGSKCWPLISRYRAAVRTQSPRLEMIDSLFQPIENTEKGDNGIMNELFVEFYRTSRARKPKQIIIFRDGVSESQFEQVLKIEVDQIIKAYQRLGESDVPKFTVIVAQKNHHTKLFQAKGPENVPAGTVVDTKIVHPTNYDFYMCAHAGKIGTSRPAHYHVLLDEIGFSPDDLQNLIHSLSYVNQRSTTATSIVAPVRYAHLAAAQVAQFTKFEGISEDGKVPELPRLHENVEGNMFFC
What is the function of this protein?
Involved in transcriptional gene silencing (TGS).  Component of the RISC complex that associate with the small interfering RNA (siRNA) pathway involved in direct cytosine methylation at endogenous DNA repeats.  Required for the accumulation of specific siRNAs derived from transgene and heterochromatin-related endogenous loci.  Involved in RNA-directed DNA methylation (RdDM) at specific endogenous loci.  Probably not required for the accumulation of siRNAs derived from transgene inverted repeats that induce post-transcriptional gene silencing (PTGS).  Associates mainly with small RNAs of 24 nucleotide in length and preferentially recruits small RNAs with a 5' terminal adenosine.  Targeted by turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO6 function in RNA silencing.
What are the official names of this protein?
Protein argonaute 6.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Ago subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: POC1B_XENLA
Sequence: MASALDDPALQRHFKGHKDAVTCVDFSPDSKQLASSSADACVMIWNFKPQSRAYKYPGHKEAVTCVQFSPSGHLVASSSKDRTVRLWAPNIKGESTVLKAHTAVVRCVNFSSDGQTFITASDDKSIKAWNLHRQRFLFSLTQHTNWVRCARFSPDGRLIASCSDDKTVRIWDLTNRLCINTFVDYKGHSNYVDFNQMGTCVASAGADSTVKVWDIRMNKLLQHYQVHNAGVSSLSFHPSGNYLLTASSDGTLKILDLLEGRLIYTLHGHQGPVLSVTFSKSGDQFASGATDAQVLVWKTNFDKYSVKEIVKLQQKRTCPEAPPHLNDIYPRTPHLHSSSGHSIEINPMCEVADTQTFDPPIINVGANLPYCRRTKAVHTLNKHVRNDNYPTPPVAFSYTEGQKEHPLVEEQGVLPPSLSNTLEQIVDQLNVLTQTVSILEHRLTLTEDKLKECLENQQKTSAHASESD
What is the function of this protein?
Plays an important role in centriole assembly and/or stability and ciliogenesis.  Involved in early steps of centriole duplication, as well as in the later steps of centriole length control.
What are the official names of this protein?
POC1 centriolar protein homolog B, Pat-interacting protein 1, Pix1, xPix1, WD repeat-containing protein 51B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat POC1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: HIS3_PROA2
Sequence: MSENQDLQKSFLETVKFDDKGLVPAIVQDFETGKVLMMAWMNRQSLEMTLEKKKACYWSRSRQKLWLKGESSGNMQNVHDILIDCDGDTLLLKVSQTGGACHMGYQSCFYRKTKDDLSMEICDTLMFNPEDVYGKQS
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_THEP1
Sequence: MPKILKFNEEARRALERGVDKVANAVKVTLGPKGRNVVIEKSWGSPTITNDGVSIAKEIELEDKFENLGAQLVKEVASKTNDVAGDGTTTATVLAQAMIKEGLKNVAAGANPILLKRGIDKAVEKAVEEIKKVSKKLSGREDIAHVAAISANSAEIGELIAEAMDKVGEDGVITVEDSKTLETYVEFTEGMQFDRGYISPYFVTDAEKMEVVLKEPFILITDRKLSAVKPLIPILEKVAQTGRPLLVIAEDVEGEVLTTLVLNKLKGTLQSCAVKAPGFGERRKAMLQDIAILTGGQVASEELGINLEDLTLEDLGRADLVRVKKDETIIIGGKGDPEAIKKRIAQIKAQIEETTSEYEKETLQERMAKLAGGVAVIKVGAATETELKEKKHRIEDALSATRAAVEEGIVPGGGVTLLRARKAVEKVIEELEGDEKIGAQIVYKALSAPIKQIAENAGYDGAVIIEKILSNDDPAYGFDALRGEYCNMFERGIIDPAKVTRSALQNAASIAGMLLTTEVLIVEKPEEKKETPSIPEEF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_LACCB
Sequence: MNQEEMLDRQKHIRNFSIIAHIDHGKSTLADRILELTDTIAKRDMQAQVLDDMALERERGITIKLNAVELHYKAKNGETYIFHLIDTPGHVDFSYEVSRSLAACEGALLVVDATQGVEAQTLANVYLAIDDDLEIIPVINKVDLPSAQPDVVKEEIEEMIGLDASDAILASGKTGLGVPEILERIVTDVPAPSGDLNAPLQALIFDSVYDDYRGVVLDVRVKEGQVKVGDTIQLMSNGKQFQVTEVGVMSPKAVKRDFLMVGDVGYITAAIKTIQDTRVGDTVTLADRPAEKPLKGYRKITPMVYSGLFPVDNAKFNDLREALEKLQLNDAALEFEPETSQALGFGFRCGFLGLLHMDVVQERLERDYDLDLIMTAPSVDYEIIMTDGTEKTIDNPADMPEVSEIKEIREPYVKASIMVPNDYVGPVMELSQRKRGEFVTMDYLDKYRVNVIYNLPLSEIIYDFFDDLKSSTKGYASLDYEITGYRQSDLVKMDILLNGDPVDALSTIVHKDFAYERGKAIVARLKTTIPRQQFEIPIQAAIGNKVIARSTVKAYRKNVLAKCYGGDITRKRKLLEKQKAGKKRMKSVGSVEVPQEAFMSILKMNDEESQGK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL6_SPIKU
Sequence: MSRIGNRELKIPVGVEVTIQPNNVIVKSAKGQLEQAIPSVITVAAKEGVVTTTRANDVKHSKQLHGTINSLIQGMLEGVSKGFKKELEINGVGYRAALAGNKLTLSLGYSHPIEYKIPQGITITLPKPTQIIVEGISKKLVGEVAANIRNYRKPEPYKGKGIKYKNKHIIRKEGKSAGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: Y1950_THEYD
Sequence: MARIELGKEGEKLAIDYLLTKGYKILEKNFRTPFGEIDIIAKDGNFIVIIEVKRRLSDKFGKPELSVNYTKQQKLKKLALYYISMLKKEYPVRFDVIAINDKKIEHIENAFF
What are the official names of this protein?
UPF0102 protein THEYE_A1950.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: SSRP_RUEST
Sequence: MAKQKTDPNYKVIAENRRARFDYAIEQDLECGIMLEGSEVKSLRAGGSNIAESYAAVEEGELWLVNSYIAPYEQAKVFKHEERRRRKLLVSRKEMADLWNATQRKGMTLVPLVLYFNHRGMAKIKIGIAKGKKNHDKREAQAKRDWSRQKQRLLKDHG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PSA_STRRD
Sequence: MSMPFGYVSPEQQMRDKADYARKGIARGRSVVVLQYEHGILFVAPNPSRALHKISEIYDRIGFAAVGRYNEFEALRLGGIRYADINGYNYARDDVTARGLANLYAQNLGQIFTESMKPFEVEIVVAEVGDSSDEDHIYRLTFDGSVFDETGLVAMGGQAEAVAGRLKERYRDGLPLAEALEAALFALTEPGGERSPASQLEVAVLDRNRPHRKFLRLAGPRLERLLAEGSATSATSATPGEAEAPATAPEGDVDTGSNG
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PrcA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSPD1_RAT
Sequence: MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVIDAAGAVKPQCCVDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVIATLLPSAKEQQKEEEEKRIKEHLTESVFFEQSCQPENRAVSSGPSLLTVFLGVVCIAALMLPTLGDMESLVPLYLHLSVNQKLVAAYILGLITMAILRT
What is the function of this protein?
Plays a role in differentiation and/or proliferation of mesenchymal stem cells.  Proposed to be involved in epithelial-to-mesenchymal transition (EMT).  However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.
What are the official names of this protein?
Motile sperm domain-containing protein 1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: Y1215_ARATH
Sequence: MVNIRVQKAPESPRTMEVGEIDTRAPFQSVKAAVSLFGEVAVSKQRSTPRRSRLSSESVCDKETQLMLVHKEFMKIKQKLDNAESTRSRALDDLSKAKKTMEDLSNKLETVNKSKQSAIDTKETVQQREEQLEHDKCHGSPPHHHELDVAREQYISTTVELDAAKQQLNKIRQSFDSAMDFKATALNQAAEAQRALQVNSAKVNELSKEISDMKDAIHQLKLAAAQNLQEHANIVKEKDDLRECYRTAVEEAEKKLLVLRKEYEPELSRTLEAKLLETTSEIEVLREEMKKAHESEMNTVKIITNELNEATMRLQEAADDECSLRSLVNSLRMELEDLRREREELQQKEAERLEIEETKKLEALKQESLKLEQMKTEAIEARNEAANMNRKIESLKKETEAAMIAAEEAEKRLELVIREVEEAKSAEEKVREEMKMISQKQESKKQDEESSGSKIKITIQEFESLKRGAGETEAAIEKKLATIAAELEEINKRRAEADNKLEANLKAIEEMKQATELAQKSAESAEAAKRMVESELQRWRQQENVQLA
What are the official names of this protein?
WEB family protein At1g12150.
What is the protein family that this protein belongs to?
Belongs to the WEB family.
Protein: MET14_CHICK
Sequence: MNSRLQEIRERQKLRRQLLAQQLGAENADSIGAVLNSKDDQREIAETRETCRASYDTSAPNAKRKYPDEGEADEEEIEEYKDEVELQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELISKSNTPPMYLQADLEAFDIRELKSKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIEEIAAPRSFVFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVRRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNFNAETYSSYFTAPNSHLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGERGRERNRTNFRGERGGFRGGRGGTHRGGFPTR
What is the function of this protein?
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis.  In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core.  N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing.
What are the official names of this protein?
N6-adenosine-methyltransferase non-catalytic subunit, Methyltransferase-like protein 14.
What is the protein family that this protein belongs to?
Belongs to the MT-A70-like family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FGFP1_BOVIN
Sequence: MRTHGLTLLSLLLLAVPMLLVEAKKEGRNRRGSKASADESLALGKPGKEPRSQPTNYPIKGKFVTPDHADCRWAVTKQEEGIVLKVECTQRDNTFSCFFTGNPTSCLELHKNNAYWKQIGRNLRSQKVICGDAKSVLKTRVCRKKFPESNLKLVNSTLIRIKKPSQELMEPSPMDTVEVTTSSSPEKTQTMATKDPQCEEEDLKNQRKAALEYCGETWGSLCNFFLSMVQGSSC
What is the function of this protein?
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs.  Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity).
What are the official names of this protein?
Fibroblast growth factor-binding protein 1, FGF-BP, FGF-BP1, FGF-binding protein 1, FGFBP-1.
What is the protein family that this protein belongs to?
Belongs to the fibroblast growth factor-binding protein family.
What are the subcellular locations of this protein?
Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Note=Extracellular and plasma membrane- associated.