PharMolix/UniProtQA huggingface dataset:
Protein: GLMM_ECO7I
Sequence: MSNRKYFGTDGIRGRVGDAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSALFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDAVEEAIEAEMEKEISCVDSAELGKASRIVDAAGRYIEFCKATFPNELSLSELKIVVDCANGATYHIAPNVLRELGANVIAIGCEPNGVNINAEVGATDVRALQARVLAEKADLGIAFDGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKMQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMARNHMSLHDLCSGMKMFPQILVNVRYTADSGDPLEHESVKAVTAEVEAALGSRGRVLLRKSGTEPLIRVMVEGEDEAQVTEFAHRIADAVKAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: ISPF_SALDC
Sequence: MRIGHGFDVHAFGGEGPIIIGGVRISYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLMKAAK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RL135_PLAVT
Sequence: MRRLYLFVLILATFLTTSHGIVDASQDFQHLRRGLQEEAGEDEERIKLSGFKLPKSFGKRFKQKLSTKTKAFATRAASRMFQKKKGPLYGKYYKNAGKPKRQTPQIAATGPAKPKVQSPEEAAAVPGPYGQSLEYRVAQKVPLREREAFNPAKLSKINEMIPV
What is the function of this protein?
Secreted effector that completely suppresses the host cell death induced by cell death-inducing proteins.
What are the official names of this protein?
Secreted RxLR effector protein 135.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Host cytoplasm.
Protein: GLNA4_MAIZE
Sequence: MACLTDLVNLNLSDTTEKIIAEYIWIGGSGMDLRSKARTLPGPVTDPSKLPKWNYDGSSTGQAPGEDSEVILYPQAIFKDPFRRGNNILVMCDCYTPAGEPIPTNKRYSAAKIFSSPEVAAEEPWYGIEQEYTLLQKDTNWPLGWPIGGFPGPQGPYYCGIGAEKSFGRDIVDAHYKACLYAGINISGINGEVMPGQWEFQVGPSVGISSGDQVWVARYILERITEIAGVVVTFDPKPIPGDWNGAGAHTNYSTESMRKEGGYEVIKAAIEKLKLRHKEHIAAYGEGNERRLTGRHETADINTFSWGVANRGASVAVGQTEQNGKGYFEDRRPASNMDPYVVTSMIAETTIVWKP
What is the function of this protein?
Plays a role in the flow of nitrogen into nitrogenous organic compounds.
What are the official names of this protein?
Glutamine synthetase root isozyme 4, GS107, Glutamate--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANR_ECO45
Sequence: MSPMNAFDPQAEDSTTTIGRNLRSRPLARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTIIGELSGMAKDFLSHPGGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNAAFIRSDVDFHRVLAEIPGNPIFMAIHVALLDWLIAARPTVADQALHEHNNVSYQQHIAIVDAIRRHDPDEADRALQSHLNSVSATWHAFGQTTNKKK
What is the function of this protein?
Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids.
What are the official names of this protein?
HTH-type transcriptional repressor NanR.
What is the protein family that this protein belongs to?
Belongs to the NanR family.
Protein: RGHRB_BACSU
Sequence: MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTPKPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHLPIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator RghRB.
Protein: MIAB_PSYIN
Sequence: MSMKLHVKTWGCQMNEYDSSKMADLLNSTNGYISVEHAEDADVVLLNTCSIREKAQEKVFHQLGRWKKLKVNKPNLVIGVGGCVASQEGKAIRSRAPFVDIVFGPQTLHRLPEMIKEVQENKGTVVDVSFPEIEKFDSLPEPKADGATAFVSIMEGCSKYCSFCVVPYTRGEEVSRPLDDVLLEVAQLAEQGVREVTLLGQNVNSYLGATYDGDTCSFAELLRFVASIDGIDRLRYVTSNPIDFSDEIIAVYEDTPELVNFLHLPVQAGSDRILAAMKRGHTVAQYKDQIARLLQVRPELTVSSDFIIGFPNETDHDFEQTMDLIKYINFDTSYSFIYSQRPGTPAADMPDDVTLETKKQRLAILQDRIQQQSQGIGRKMVGSVQRILVEGPSRKNIMELCGRTENNRIVNFEGDHRSIGGFVDVEITEVHTNSIRGKFIRGEAEMNLRESIRPSDIVNKHENKSAVNSYIPA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCAP_I84A3
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDHEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWMRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLAWMACHSAAFEDLRVSSFIRGTRVVPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNNNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMESARPEDLSFQGRGVFELSDENATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: T2MT_METTF
Sequence: MSNLLQAIMNIKSIQERNLGSYKGVQDSKNRMNQMGVTLEVFLKDAFCNTFDIENKDLVYSEYFSYLGNQNNPPDMILKGGDAVEVKKITGIKTSIQLNSSYPKSKLFVSDSRITEACKNCEDWEVKDIIYAIGTIPNRVLKLMFFVYGDCYAASPSIYQRIVEEVKGGLHSTGLEFSETNELGRINRVDPLGITDLRVRGMWIIKHPIKVFKNIIPPESIKNNNFNLIALMKAEKYKQFPKKDRKRIEAEDNIEVTDVKIKDPDNPAKLLDSVLVRYDEI
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GGCC-3' and cleaves after G-1.
What are the official names of this protein?
Type II restriction enzyme MthTI, R.MthTI, Endonuclease MthTI, Type-2 restriction enzyme MthTI.
What is the protein family that this protein belongs to?
Belongs to the NgoPII type II restriction endonuclease family.
Protein: RS8E_SULIM
Sequence: MGFYQGPDNRKITGGLKGKHRDKRKYEIGNPSTLTTLSAEDIRTKDRTLGGNFKVRLKYTTTANVLDPATNTAKKVKILEVLETPANKELARRGIIIRGAKIRTEAGLAVVTSRPGQDGVINAVLLKNESQGS
What are the official names of this protein?
30S ribosomal protein S8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
Protein: ISPE_MANSM
Sequence: MKTHQFSTALFSDYKQGDSFNFPCPAKLNLFLYINGRRTDGYHELQTLFQFLDYGDWLSIKVRNDGKIRLTPEIPDLKTEDNLIYRAAKLLQQKTACRLGADLHLDKVLPMGGGVGGGSSNAATALVALNYLWKTGLSVNELAELGLKLGADVPIFVHGKAAFAEGVGEKITYCEPPEKWYAVIKPNVSISTAKVFSEPDLTRDTKKKPLEQLLQQEYTNDCEKVVRKLYPEVEELLRWLVKYAPSRLTGSGACVFAEFADEQSAQTVFNLKSKQFSGFVAQGLNVSPLHKMLEQLNRQNHG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: KBTB3_HUMAN
Sequence: MELAMDNSYAFNQRSTCNGIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQFNKYRDPWFSNLCA
What are the official names of this protein?
Kelch repeat and BTB domain-containing protein 3, BTB and kelch domain-containing protein 3.
Protein: FSAA_ECOLI
Sequence: MELYLDTSDVVAVKALSRIFPLAGVTTNPSIIAAGKKPLDVVLPQLHEAMGGQGRLFAQVMATTAEGMVNDALKLRSIIADIVVKVPVTAEGLAAIKMLKAEGIPTLGTAVYGAAQGLLSALAGAEYVAPYVNRIDAQGGSGIQTVTDLHQLLKMHAPQAKVLAASFKTPRQALDCLLAGCESITLPLDVAQQMISYPAVDAAVAKFEQDWQGAFGRTSI
What is the function of this protein?
Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction.  Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate.  Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors.  Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor.  Does not display transaldolase activity.
What are the official names of this protein?
Fructose-6-phosphate aldolase 1, Fructose-6-phosphate aldolase A, FSAA.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAV2_CALJA
Sequence: MGLETEKADVQLFMDDDSYSHHSGLEYADPEKFVDSGQDRDPHRLNSHLKLGFEDVIAEPVTTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFLAGILFATLSCLHIWIIMPFVKTCLMVLPSVQTIWKSVTDAIIAPLCTSIGRSFSSVSLQLSQD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Protein: EFGM_ASPCL
Sequence: MRCPSLARLPHRAISGLTRLPVRLQSQTFLYQRCASTAALRSPTAGPAYQSILNRHNLQRRNASAAAAAVLEAAASNPDALTQEAIIDNLDPVEATRLSRIRNIGIAAHIDSGKTTCTERILFYTGRIKAIHEVRGRDNVGAKMDSMDLEREKGITIQSAATFCDWVKKEDDGREEKYHINLIDTPGHIDFTIEVERALRVLDGAVMILCAVSGVQSQTITVDRQMRRYNVPRISFINKMDRMGANPFKAVDQINSKLKIPAAAVQVPIGAEDEFEGVVDLIRMKSIYNHGPSGEEIVIKDEIPEKVKSVVEERRRMLIETLADVDDEIAELFLDEKEPTQEQLKAAIRRATVGLKFTPVFMGTALSNKSVQPMLDGVIDYLPNPSEIENLALDQKRNEASVKLVPYNSQPFVGLAFKLEESNFGQLTYIRVYQGTLRKGANVFNARNNKKVKIPRIVRMHSNEMEEVSEIGAGEICAVFGVDCASGDSFTDGQLGYTMTSMFVPEPVISLSIKPKNNKDSANFSKAMARFQREDPTFRVTYDAESEQTLISGMGELHLDIYIERMRREYRVDCETGPPQVAYRETIGNKVEFDHLLKKQSGGPGDYARVVGWMEPTDKLEENKFEEQIVGGSISEKFLFACEKGFNLACEKGPLIGHKVLGTRMVINDGATHMTDSSEMSFKNATQQAFRKAFMESNPSVLEPMMKTVVTAPSEFQGDVISLLNKRNATINDTETGVDEFTVYADCSLNGMFGFSSHLRAATQGKGEYTMEFSHYEKAQPQLQKELIQKYLKAQADRHKK
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RNF5_HUMAN
Sequence: MAAAEEEDGGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFNAHEPFRRGTGVDLGQGHPASSWQDSLFLFLAIFFFFWLLSI
What is the function of this protein?
Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19285439, PubMed:19269966).  May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381).  Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019).  Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924).  Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966).  Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439).  Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF5, RING finger protein 5, Ram1 homolog, HsRma1.
What is the protein family that this protein belongs to?
Belongs to the RNF5 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.
Protein: RBFA_HELPJ
Sequence: MNAHKERLESNLLELLQEALASLNDSELNSLSVTKVECSKGKHHALVFVLSSDHKILSKLKKAEGLIRQFVLQASGWFKCPKLSFVLDDSLEKQLRLDAIFNEIAKGKDND
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHAX_HUMAN
Sequence: MALEVGDMEDGQLSDSDSDMTVAPSDRPLQLPKVLGGDSAMRAFQNTATACAPVSHYRAVESVDSSEESFSDSDDDSCLWKRKRQKCFNPPPKPEPFQFGQSSQKPPVAGGKKINNIWGAVLQEQNQDAVATELGILGMEGTIDRSRQSETYNYLLAKKLRKESQEHTKDLDKELDEYMHGGKKMGSKEEENGQGHLKRKRPVKDRLGNRPEMNYKGRYEITAEDSQEKVADEISFRLQEPKKDLIARVVRIIGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFLNLLKNTPSISEEQIKDIFYIENQKEYENKKAARKRRTQVLGKKMKQAIKSLNFQEDDDTSRETFASDTNEALASLDESQEGHAEAKLEAEEAIEVDHSHDLDIF
What is the function of this protein?
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus.  Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other.  Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly.  It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor.  The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.  Its compartmentalized phosphorylation cycle may also contribute to the directionality of export.  Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity).  Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA).  Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies.  Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs.  Binds also to telomerase RNA.
What are the official names of this protein?
Phosphorylated adapter RNA export protein, RNA U small nuclear RNA export adapter protein.
What is the protein family that this protein belongs to?
Belongs to the PHAX family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, Cajal body. Cytoplasm. Note=Located in the nucleoplasm and Cajal bodies. Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies.
Protein: EX3_ECOLI
Sequence: MKFVSFNINGLRARPHQLEAIVEKHQPDVIGLQETKVHDDMFPLEEVAKLGYNVFYHGQKGHYGVALLTKETPIAVRRGFPGDDEEAQRRIIMAEIPSLLGNVTVINGYFPQGESRDHPIKFPAKAQFYQNLQNYLETELKRDNPVLIMGDMNISPTDLDIGIGEENRKRWLRTGKCSFLPEEREWMDRLMSWGLVDTFRHANPQTADRFSWFDYRSKGFDDNRGLRIDLLLASQPLAECCVETGIDYEIRSMEKPSDHAPVWATFRR
What is the function of this protein?
Major apurinic-apyrimidinic endonuclease of E. coli.  It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction.  It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities.
What are the official names of this protein?
Exodeoxyribonuclease III, EXO III, Exonuclease III, AP endonuclease VI.
What is the protein family that this protein belongs to?
Belongs to the DNA repair enzymes AP/ExoA family.
Protein: ENO_HAEI8
Sequence: MAKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGLAAAPSGASTGSREALELRDGDKSRFLGKGVLKAVAAVNNEIAQAIVGKDATNQAEIDQIMIDLDGTENKSNFGANAILAVSLANAKAAAASKGLPLYAYIAELNGTAGVYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLREALRIGAEVFHNLAKVLKSKGMSTAVGDEGGFAPNLASNADALACIKEAVEKAGYVLGKDVTLAMDCASSEFYNKENGMYEMKGEGKSFTSQEFTHYLEELTKQYPIVSIEDGQDESDWEGFAYQTKVLGDRVQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRIAKYNQLIRIEEALERAGTPAAFPGLKAVKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RCP_VIBCH
Sequence: MPAYNPSARFDKAPFHSSLFQYCVIPKRLGVSGRRQVRNHMSIDNYVIGDQVELHEATSSKVKKVSSNHRTRFTQGVTMRILITGGTGFVGFQLIKLLSSHELLVLTRDLTKAAQRFAHIPSQNLQLLSPLDELSDFNGIDAIINLRPDNRLPINAEEKPKAGIARSRLDITEQLVEKIRASAHPPAVFLSGSAWFLCDQQAACL
What are the official names of this protein?
Protein Rcp, Protein SulA.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: CHSTD_HUMAN
Sequence: MGRRCCRRRVLAAACLGAALLLLCAAPRSLRPAFGNRALGSSWLGGEKRSPLQKLYDLDQDPRSTLAKVHRQRRDLLNSACSRHSRRQRLLQPEDLRHVLVDDAHGLLYCYVPKVACTNWKRVLLALSGQARGDPRAISAQEAHAPGRLPSLADFSPAEINRRLRAYLAFLFVREPFERLASAYRNKLARPYSAAFQRRYGARIVQRLRPRALPDARARGHDVRFAEFLAYLLDPRTRREEPFNEHWERAHALCHPCRLRYDVVGKFETLAEDAAFVLGLAGASDLSFPGPPRPRGAAASRDLAARLFRDISPFYQRRLFDLYKMDFLLFNYSAPSYLRLL
What is the function of this protein?
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin.  Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices.  Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl.  No activity toward dermatan.
What are the official names of this protein?
Carbohydrate sulfotransferase 13, Chondroitin 4-O-sulfotransferase 3, Chondroitin 4-sulfotransferase 3, C4ST-3, C4ST3.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: LIGB_PSEMY
Sequence: MLAMKRWIAPLLLPLIAQAEPCPDWPDSRAQVEFAALSQQIAQWDDAYHNQGRSPIADELYDQARERLQRWQQCFAPARQPLPEPLTGSAGPIAHPVPQTGLRKLNDAAIGEWIGSRDDLWIQPKVDGVAVTLVYRQGRLHQAISRGDGRHGQDWSARARQLPAVPTRLPEALDLVLQGELYWRLEDHLQARDGGAGARGKVAGMMARHELSDTDGAAIGLFVWDWPDGPASMDERLSQLQALGFADSQHYSKPIRSVEEARQWRQHWYRHRLPFASDGVVLRQGTRPAGARWQAEAPHWAVAWKYPASQALAVVQAVDFRIGRSGRITPVLRLQPVDLDDRRISRVALGSVPTWKSLDVRPGDQVAIRLAGLTIPRLDSVIWRSPHRAPVEVPRSADYHALSCWRSSPSCQHQFQARLAWLSSKQGLALSGVGPGTWSSLPLQGLLDWLELDKAQLQSLPGIGPRRAAQLQQAFAQARDRPLQQWLRALGAPPGFDAGGLDDWPSLIERQRDDWLRRPGVGPKGADRLLAFFSHPEVQRLGRQLQQAGVAGFQPQAGPPRS
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.