PharMolix/UniProtQA huggingface dataset:
Protein: PITM3_MOUSE
Sequence: MAKAGSAGGPSPGGGAPWHLRNVLSDSVESSDDEFFDAREEVAEGKNAILIGMSQWSSNDLVEQIETIGKLDERQGDGATACTSSILQEKQRELYRVSLRRQRFPAQGSIEIHEDGEEGCSQRSCKTHVLLLVLHGGNVLDTGSGDPSCKAADIHTFSSVLEKVMRAHFPAALGHILIKFVPCPAICSEAFSLVSNLNPYSHDEGCLGTSQDHVPLAALPLLAISSPQYQDAVATVIERANHIYGEFLKSSDGIGFNGQVCLIGDCVGGLLAFDAICYSAGPSGDSPGSSSRKGSISSTQDTPVVVEEDCSLASSKRLSKSNVDVSSGVEDEDPKRPLPRKQSDSSTYDCEAITQHHAFLSSIHSSVLKDEAEAPAAGTPQLSEVSLGRFDFDVSDFFLFGSPLGLVLAMRRTVLPGIDGFQMRPACSQVYSFFHCADPSASRLEPLLEPKFHLVPPVSVPRYQRFPLGDGQSLLLADALHTHSPLFLEGSSRGSPPLLDAPASPPQAPRFQRTERRLSKGSSHSDSSESSDSLAPMGASRITAKWWGTKRIDYALYCPDVLTAFPTVALPHLFHASYWESTDVVAFILRQVMRYESASVKESTGLDPTALSPANPREKWLRKRTQVKLRNVTANHRANDVIAAEDGPQVLVGRFMYGPLDMVALTGEKVDILVMTEPSSGRWVHLDTEITNNSGRITYNVPRPRRLGVGVYPVKMVVRGDQTCAMSYLTVLPRGMECVVFSIDGSFAASVSIMGSDPKVRPGAVDVVRHWQDLGYMILYITGRPDMQKQRVVSWLSQHNFPQGMIFFSDGLVHDPLRQKAIFLRNLMQECFIKITAAYGSTKDISVYSVLGLPASQIFIVGRSTKKYQTQCQFLSEGYAAHLAALEASHRSRPKKNNSRMILRKGSFGLHAQPEFLRKRNHLRRTMSVQQPDPPAANPKPERAQSQPESDKDHERPLPALSWARGPPKFESVP
What is the function of this protein?
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro).  Binds calcium ions (By similarity).
What are the official names of this protein?
Membrane-associated phosphatidylinositol transfer protein 3, Phosphatidylinositol transfer protein, membrane-associated 3, PITPnm 3, Pyk2 N-terminal domain-interacting receptor 1, NIR-1.
What is the protein family that this protein belongs to?
Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
What are the subcellular locations of this protein?
Endomembrane system; Peripheral membrane protein.
Protein: RPOA_GRABC
Sequence: MVIQRNWQSLIKPEKLDVEPGNEPSRIATIVAEPLERGFGMTLGNAIRRILLSSLQGAAVTAVQIDGVLHEFSSVAGVREDVTDIVLNIKQLALRMHGEGPKRMMLTATGPGEVTAGQIQAGHDIEIMNPDLVLCTLDDGVKLGMEFTVNLGKGYVPASQNRQEDSPIGLIPIDAIYSPVRRVSYKVEPTRVGQVTDYDKLLLTVETNGAVTPEDSVALAARILQDQLQLFINFEEPQQVRHDEPQDDLPFNRNLLRKVDELELSVRSANCLKNDNIVYIGDLVQKSEQEMLRTPNFGRKSLNEIKEVLANMGLSLGMSVSGWPPENIEDLAKRLEEPF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RR19_LOBMA
Sequence: MTRSLKKNPFVAKHLLRKIEKLNTKAEKEIIRTWSRASTIIPTMIGHTIAIHNGREHLPVYIIDLMVGHKLGEFSPTINFRGHAKNDNRSRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CMOA_SHIFL
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCKIIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHKAGFEHSELWFQCFNFGSLVALKAEDAA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: RBSC_BACSU
Sequence: MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLEPLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLAIILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYGFQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTRVKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIVGTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Ribose import permease protein RbsC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HSLU_XYLFM
Sequence: MPSKTDFTSSTMTPREIVQELDRHIVGQQVAKRSVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATLANAPFVKVEATRFTEVGYVGKDVEQIGRDLVDTAVKMYREQAKVRVRTQVEEYAEERILDALLPRRSVGIGFDVDADVIRQEPSAHDSETRAKFRRMLRSGELEDREIELDVAVNVSMDIMTPPGMEEMGQQLRQMFSNIGGGKSQKRKLTIKAARPLLIEEEAAKLVNEDEIRAAAIEACEQNGIVFIDEIDKVVKRGDTVGGGDVSREGVQRDLLPLVEGSNVSTKYGTIRTNHILFIASGAFHLTKPSDLIPELQGRFPIRVELDALSKADFIRILTEPKAALTKQYQELLKTEGVSLDFTEDAIDRIAEIAYLVNERQENIGARRLHTVLERLLETLSYESPDRDGESVTVDADYVNAHLGELVKDPDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOCD_ECO57
Sequence: MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVGDFLKKLPKPYVMLFDLHGMDERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMMPQTWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPARVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQNTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRILEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRIRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: EFP_MAGSA
Sequence: MKINANLIRPGNILEHNGRQYAVLKTQIVQPGKGGAFITVEMRDIRTGNKTNERWRTADTIEKCNVEAKECTFLFKDDSNMTFMDSESFEQFTMPNDTLGDTIGFLQDGMVVEVDFVEGSPVSITLPEKVVMKVVEADPVVKGQTASSSYKPAKLENGMKILVPPFLEEGEVIIVNTTDCSYVERFKG
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_LEUMM
Sequence: MAFVDQAQIEVKAGKGGDGIVSFRHEKFVAMGGPFGGDGGHGGSIIFKVDEGLRTLMDFRYNRHFKAQPGGNGGTKGMTGASADNRVVKVPQGTTVSDADTGEVLADMLENGQELVVAKGGRGGRGNIHFATPANPAPELSENGEPGQIRNLKLELKVLADVGLVGFPSAGKSTLLSVVSNAKPKVAAYHFTTLSPNIGMVRLDDDRDFVMADLPGLIEGASQGIGLGFQFLRHVERTKVILHLVDMSGIEGTDPYTQYRKILDELQQYDETILNRPQIVVPTKMDMPDSEENLAKFRKEVATDSGLPIQPEIVPISSITRDGVKDLMRLTADMLATAPAPESYRPETKNDTSEKSYTFKPETHDFTVEWIADEERWLLSGAEIEKLFLMTNIQRDATIMRFARQLRHMGVDDKLREAGAKDGDDVRINNSDFVFEFSE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_DECAR
Sequence: MGQKIHPTGFRLAVTKNWSSRWYANSKDFPGMLNEDIKVREYLKRKLAHASVGRVLIERPAKNARVTVYSARPGVVIGKKGEDIEQLRTDLQRIMGVPVHVSIEEIRKPEIDAQLIADSIAQQLEKRIMFRRAMKRAMQNAMRLGAQGIKVMSAGRLNGAEIARSEWYREGRVPLHTLRADIDYATSEALTTYGIIGIKVWVYKGDMLDRNEQPVAEEPAADDRRPRRTPGRPDGDKPRTRTVKKVDGAADPAKRVRKAGA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: MPAP5_PHLPR
Sequence: MAVHQYTVALFLAVALVAGPAASYAADLGYGPATPAAPAAGYTPATPAAPAEAAPAGKATTEEQKLIEKINAGFKAALAAAAGVQPADKYRTFVATFGAASNKAFAEGLSGEPKGAAESSSKAALTSKLDAAYKLAYKTAEGATPEAKYDAYVATLSEALRIIAGTLEVHAVKPAAEEVKVIPAGELQVIEKVDAAFKVAATAANAAPANDKFTVFEAAFNDAIKASTGGAYESYKFIPALEAAVKQAYAATVATAPEVKYTVFETALKKAITAMSEAQKAAKPAAAATATATAAVGAATGAATAATGGYKV
What are the official names of this protein?
Pollen allergen Phl p 5.0101, Allergen Phl p 5a, Allergen Phl p V.
What is the protein family that this protein belongs to?
Belongs to the Poa p IX/Phl p VI allergen family.
What are the subcellular locations of this protein?
Secreted.
Protein: WRKY5_ORYSJ
Sequence: MEMMVQKQRHEEGEEERGGLCAREIKELDFFSAAGAGAGRRDDDDVLRADGISSSHAGFMVSTALDLLTAVNDGDHHEEKKGQSNIHQSKQMDAAATTVEGELRQAGEENRRLRRRLEELTSSYGALYHQLVQAQQLHTKHQQQAPIAGVQLLDALAAASPASHRRRAAAAVDGDRTADSDGGEGDENVSPSLGSKRPAAAATLTRLTPESGSGGENNGGGEQAPAAEMAPCRKARVSVRARSEAPMISDGCQWRKYGQKMAKGNPCPRAYYRCTMASQCPVRKQVQRCAEDKSILITTYEGTHSHPLPPAAAAMAKTTSAAAAMLLSGPAVSRDALFAAHHHVVAPPPFFHHPYAGSTMATLSASAPFPTITLDLTQPPPTTTTTAAAAMLQLHRPYAFSSLPFSMYGAGGGSHRPPVVLPPPSSVVETMTAAITRDPNFTTAVAAALSSIMAGGGAQARTPPRGGSDAAGDINGGGGADHATAGARAAAAATQPCGTSPT
What is the function of this protein?
Transcription factor that acts as positive regulator of leaf senescence (PubMed:31505875).  Is involved in both the onset and progression of leaf senescence (PubMed:31505875).  Upregulates the expression of genes controlling chlorophyll degradation and leaf senescence (PubMed:31505875).  Acts as positive regulator of the senescence-associated NAC genes NAC4 and NAC58 (PubMed:31505875).  Acts as positive regulator of abscisic acid (ABA) biosynthesis during leaf senescence (PubMed:31505875).  Acts as negative regulator of drought tolerance by inhibiting ABA-induced stomatal closure during drought stress (PubMed:34718775).  Functions as a direct negative regulator of MYB2 transcription through binding to the repeated W-boxes of the MYB2 promoter region (PubMed:34718775).
What are the official names of this protein?
Transcription factor WRKY5, OsWRKY5, WRKY transcription factor 5.
What is the protein family that this protein belongs to?
Belongs to the WRKY group II family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRH_AGRFC
Sequence: MMSSKPIYKRVLLKASGEALMGDQGFGIDVAVADRIASDIAEARAMGVEVGVVVGGGNIFRGVAVASKGGDRVTGDHMGMLATVINALALATSLRKLSIDTVVLSAIAMPEICESFSQRAALHHLAQGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIFKGTQVDGIYSADPKKDPTATRFDELTHSEVLGKGLAVMDIAAVALARENHIPIIVFSIHEKGGFAQILTGGGRKTIVHDK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APK1_ARATH
Sequence: MIAAGAKSLLGLSMASPKGIFDSNSMSNSRSVVVVRACVSMDGSQTLSHNKNGSIPEVKSINGHTGQKQGPLSTVGNSTNIKWHECSVEKVDRQRLLDQKGCVIWVTGLSGSGKSTLACALNQMLYQKGKLCYILDGDNVRHGLNRDLSFKAEDRAENIRRVGEVAKLFADAGIICIASLISPYRTDRDACRSLLPEGDFVEVFMDVPLSVCEARDPKGLYKLARAGKIKGFTGIDDPYEPPLNCEISLGREGGTSPIEMAEKVVGYLDNKGYLQA
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.  Essential for plant reproduction and viability.  Required for the production of glucosinolates.
What are the official names of this protein?
Adenylyl-sulfate kinase 1, chloroplastic, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase 1, Adenosine-5'-phosphosulfate kinase 1, APS kinase 1.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: COOA1_MOUSE
Sequence: MHLGAYRTRHGKVSPTTETKLFLRFIVLCVVWISVHAQGQGIDILQQLGLGGRDVRYTSSVTAVPSSSWSTPLPQGVHLTDFGVILTDNAYIESPLVNILPISLRQPLTVLIGLQSFKVNNAFLFSIRNNNRLQFGVQLLPKKLIVHVGGKQTVTFNYSAHDERWHSFAITVDHHVISMFVECGKRHFSGETTSDVQTFDPHSVFTLGSINNSSAHFEGTVCQLEIMPSTAASAEYCRHLKQQCLRADASQAQRNLPHTAGMPTRHPAHTPLPRGFPGTDSPQKRFTEQDSLPKGFDGTELPRETFADGKSIPNNRSNGSATVHESQEHQTPRAQLTSFHSGNISAVTLPNYRIQAKEITTKEETNLTLSVAHHLPSEARMNEEGRINPLFAGFDNITQHEEAAGLPLPKKASSGFAHTNQDTMKNLEKALTANLYTNELIEMERILNSTLYRVMYGPSVDNHLELRKEGEFYPDATNPIEGSYEPQAYDYYSYEDYNAVLDMEYLRGPKGDPGPPGPPGPMGIPGPSGKRGPRGIPGPHGNPGLPGLPGPKGPKGDPGLSPGQAASGEKGDPGLLGLVGPPGLQGAKGLKGHPGLPGLRGEHGLPGLAGNIGSPGYPGRQGLAGPEGNPGSKGVRGFIGSPGEVGQLGPEGERGTPGVRGKKGPKGRQGFPGDFGDRGPAGLDGSPGLVGGTGPPGFPGVTGSVGPAGPTGPPGAPGPMGLSGSRGPSGIKGDKGEQGVAGEPGEPGYPGDKGNIGSPGPPGIRGKSGPSGQPGDPGPQGPSGPPGPEGFPGDIGIPGQNGPEGPKGHLGNRGPPGPPGLKGTQGEEGPIGPFGELGSRGKPGRKGYMGEPGPEGLKGEVGDQGDIGKTGETGPVGLPGEVGITGSIGEKGERGSPGPLGPQGEKGVMGYPGPPGAPGPMGPLGLPGLVGARGAPGSPGPKGQRGPRGPDGLAGDQGGHGAKGEKGNQGKRGLPGLPGKAGSPGERGVQGKPGFQGLPGSSGDVGPAGEPGPRGLPGIAGLPGEMGVEGPPGTEGDSGLQGEPGAKGDGGPAGSAGATGEPGPRGEPGAPGEEGLQGKDGLKGAPGGSGLPGEDGDKGEMGLPGTAGPVGRPGQMGLPGPEGIVGTPGQRGRLGKKGDKGQVGPTGEAGSRGPPGSVGENGPKGARGTRGAVGPLGLMGPEGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPGPPGEPGPMGEQGETGEHGEEGYKGHMGVPGLRGATGQQGPPGEPGDQGGQGPKGERGSEGPQGKRGVPGPSGKPGIPGVPGFPGPKGLQGYPGVDGMSGYPGKPGLPGKQGLLGVPGSPGRTGVAGSPGPQGGKGASGPPGSPGAPGPKGEQGLPGQPGVPGQRGHRGTPGDQGLRGAPGLKGQPGEHGDQGLAGFQGFPGPRGPEGDAGIVGIVGPKGPIGQRGNTGPLGREGIIGPTGGTGPRGEKGFRGETGPQGPRGQPGPPGPPGAPGPRRQMDINAAIRALIESNSAQQMESYQNTEGTLISHSSDIFKTLTYLSSLLSSIKNPLGTRENPARICKDLLSCQYKVSDGKYWIDPNLGCSSDAFEVFCNFSAGGQTCLSPVSVTKLEFGVSKVQMNFLHLLSSEATHTITIHCLNTPRWSSTWADGPELPISFKGWNGQIFEENTLLEPQVLSDDCKIQDGSWHKAKFLFHTQNPNQLPVTEVQNLPHLGTEQKRYIESNSVCFL
What is the function of this protein?
Involved in osteoblast differentiation.
What are the official names of this protein?
Collagen alpha-1(XXIV) chain.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: HDG4_ARATH
Sequence: METKDKKEKGHMVLNSDNVFGSVSSSPTTTIQNPNYFTSFENPNFPYIFPKEEYEVMSKIESGSGKSTGSGHDPVENTAIEQEPPAAKKKRYHRHTASQIQQMEALFKENAHPDTKTRLRLSKKLGLSPIQVKFWFQNKRTQIKAQQSRSDNAKLKAENETLKTESQNIQSNFQCLFCSTCGHNLRLENARLRQELDRLRSIVSMRNPSPSQEITPETNKNNNDNMLIAEEEKAIDMELAVSCARELAKMCDINEPLWNKKRLDNESVCLNEEEYKKMFLWPLMNDDDRFRREASRANAVIMLNCITLVKAFLDADKWSEMFFPIVSSAKTAQIISSGASGPSGTLLLMFAELQVVSPLVPTREAYFLRYVEQNAEEGKWMVVDFPIDRIKPASATTTDQYRRKPSGCIIQAMRNGYSQVTWVEHVEVEEKHVQDEVVREFVESGVAFGAERWLSVLKRQCERMASLMATNITDLGVIPSVEARKNLMKLSQRMVKTFCLNIINSHGQAPTKDTVKIVSRKVCGGLVPCAVSVTLLPYSHQQVFDLLRDNQRLSQLEILFMGSSFQEVAHIANGSHLGNSISLLRINVESNSSHNVELMLQETCTDNSGSLLVYSTVDPVAVQLAMNGEDPSEIPLLPVGFSVVPVNPSDGVEGSSVSSPSCLLTVAIQVLGSNVTTERLDLSTVSVINHRICATVNRITSALVNDVGN
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Homeobox-leucine zipper protein HDG4, HD-ZIP protein HDG4, Homeodomain GLABRA 2-like protein 4, Homeodomain transcription factor HDG4, Protein HOMEODOMAIN GLABROUS 4.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class IV subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DPFGI_GIBZE
Sequence: MAQQAPTMQIDNLLAQVKVLGSSLNVADRAKVQKSLLDALSHVETPYEHMLRLSGSLACIRFGADIGLFKALVESQEPLTCSYLGEKLNANANILGRILRLLASARLVKQTGLDTFTAEKITQELAAQAMESGAHLLFDIHNRTYQALPDYLCENKSKDVDNMHNGIFQKAFSTDLSCYEYLVHNPKLQGFMQDAMKLNQTEGDWLSVLPMEDEIKRWQASDPDRVLFVDIGGGMGHQCIRLRGKYSDIPGRVVLQDMPITVERIPKPMPHGIEAMPYNFEEPQPIKNAKFYYTRNVLHGLTDSASIAALKNVAAAMGTESLLVIDDLIIPDEGACTQACQLDFVMMASIAGKKRTRDQWEDKRKYNEYKCKRNSQFL
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable).  The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350).  The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350).  Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).
What are the official names of this protein?
O-methyltransferase dpfgI, Diterpenoid pyrone biosynthesis cluster protein I.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: MUTL_CHLL2
Sequence: MAKISRLPDTVANKISAGEVVQRPASVVKELLENAIDAGASRITVMIKDAGKELIRIIDNGTGMNREDALLCVERFATSKISVVDDLDTLMSLGFRGEALASISSVSHFELKTRQAFSPLALKFRYEGGALAEESEVSGEEGTSISVRNLFYNVPARRKFLKSNATEFRHIFESVRSLSLAYADIEWRMYNDDEELFHFRNPDIRERLNYYYGSDFSEGLISITEENDYLSIHGFIGKPGMLKRHKADQLFYINRRIIQNRMLSQALQQAYGELLEDRQAPFAMLFLGIDPSRVDVNVHPAKLEVKFEDERSVRNMFYPVVKRAVQLHDFSPDASFVPDQGVQGESIQPEDEALNRRLMYHERPGRMATTAELYTDYRQHSLPQSSGKEHGPQSRQGEFFSAHEPLERWKKEGVEPEGDEVFTTMLQSRFHDDESAAGGGTEPKIWQLHNKYIICQIKNGMMIIDQHVAHERVLYERALDVMNQNVPNSQQLLFPQKIEMRQWEYEVFEEIRDDLYRLGFNLRDFGSKTVMIEGIPQDVRSGTEVTILQDMIAGYQENASKLKLEKRDNLAKSYSCRNAIMAGQKLSLEEMRSLIDNLFATRVPYSCPHGRPVIIKLMLDQLDRMFGRT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: MUTL_LACDB
Sequence: MAKIHELSENLTNQIAAGEVIERPASVVKELVENAIDAQASRIRVEVQHSGLKQISVQDNGSGIAPDQVDLAFMRHATSKIQDEHDLFNIATLGFRGEALASIAAVAHVEILTSTGGQTATRAAFAGGVKKFQEDAGSAKGTKITVGDIFYNTPARLKYLKSPKTELLKIVDIVNRIALGHPEISLTLASDGKVLLRTPGNGNLKQDVANIYGRKVAEKMLTVENEDPDFTLYGLVSEANLTRSSRNFISILLNGRYIKNYQLSSALLDGYGNKLGGKYPIAVLAIEADPLLVDVNVHPTKEEVRLSKEKELSRLITSAVTEALMDEDEASPLFQLTPFKDKTQLDQLEFNLKPNVVDTRRPDDFQLEVSQVAEPEGKTDITNKKGTETKEKAEKKENKQEEKEEKTSAPEYVDLNQVREDDQYVLTKSWDQHVKEQTALPPFAGGEEAASPVTSKADQLLRQHLPALRLLGQMEGYLLAEHGGDLYLIDQVAARRRLEYDQILASLEKDENYQQGLLEPLVFDFSVYDYQKLKDQLPLLRQLGLEMEDFGQNTLLMHSYPTWLKGEVTVQVRELLDQLLSSRENDGKSLLKLVAAKAAESNVSRRVNLTGAEAADLLLRLQTASDPYRDASGQVAVVRLSQNDLSKLFKKGK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RGF1B_BOVIN
Sequence: MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPNSDKNQIRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMIQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDVLEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQHLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).
What are the official names of this protein?
Ras-GEF domain-containing family member 1B.
What are the subcellular locations of this protein?
Early endosome. Late endosome. Midbody. Note=Localizes to midbody at telophase (By similarity). Localizes to midbody at telophase (By similarity). May shuttle between early and late endosomes. Does not colocalize with lysosomal markers (By similarity).
Protein: SYGB_STRTD
Sequence: MTKNLLVELGLEELPAYVVTPSEKQLGEKMAAFLGENRLSYESIQTFSTPRRLAVRVLGLADQQTDLTEDFKGPSKKIALDADGNFSKAAQGFVRGKGLTVDDIEFREVKGEEYVYVTKHEAGKSAKEVLAGIPEVLASLTFPVSMHWANNSFEYIRPVHTLIVLLGDEALELDFLGIKSGRVSRGHRFLGHEVEITNADSYEEDLRTVYVIADSKERENMIREQIKAIEAEQGVQVQIEEGLLNEVLNLVEYPTTFMGGFDTKYLDVPEDVLVTSMETHQRYFVVRDLDGRLKPNFISVRNGNAEHLENVVRGNEKVLVARLEDGEFFWREDQKLKIEDLVAKLANVTFHEKIGSLSEHMARAGVIAASLAEKAGLTAEEKAAVARAAEIYKFDLLTGMVGEFDELQGIMGEKYALLAGEDEAVATAIREHYLPDSADGALPETKVGAILALADKLDTLLSFFSVGLIPSGSNDPYALRRATQGIVRILDAFGWHIPMDELIDSLYGLSFDSLSYDNQAEVIRFIKARVDKMMGSTPKDIKEAVLSGSNFVVADMLEAAEALSEAAKTDGYKAAVESLSRAFNLAEKADTSVAVDASLFENDQEKALAQVAESLELTGSASDKLAQLFVLSPVIDAFFDNTMVMADDVAVKNNRLALLSALVAKAKTVAAFNQLNTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADD_DROPS
Sequence: MPGNHWYDILKKIACEGSSDIDELKGIFEKELSKRKFDSIRNIEDLIDVLERADMLSLHNVEPLRKMSSHKPKLIEALDRYGTPVSAPREPVNIYQEERLAEELRQHLRISQAFQILSAPGVAPPAFIPAAAPTPPPPQQNYITPAAFTDRKRTAVFNKISEELGRFWRIFGRKAGIGEGTMDDIEERYPRDLKSRILHLLKLIEEDDCHDPRQLLMRLCRALTECGRNDIKRKVEQIMSH
What is the function of this protein?
Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria.  Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis (By similarity).
What are the official names of this protein?
Fas-associated death domain protein, Death domain-containing adapter protein BG4.
What are the subcellular locations of this protein?
Cytoplasm.