PharMolix/UniProtQA huggingface dataset:
Protein: PANC_SHEAM
Sequence: MYTTAVIDEIRQQVRQWRASGETVAFVPTMGNLHAGHITLIKEAKQRADHVVASIFVNPMQFGKNEDLDAYPRTLAEDQAALTAAGCELLFTPTPDIIYPKGLDAQTFVEVPGISDELCGASRPGHFRGVATIVLKLFNIVQPDVALFGRKDYQQLLVIRTMVEDLSLPLEIVGVETVREASGLAMSSRNGYLTADEKARAAALKAALDALAMQIGAGTAIDAAITEANAALVTAGFRPDYLEVRSATTLALPTDADKELVVLAAAYLGKARLIDNLVFSR
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YXEC_BACSU
Sequence: MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRKWIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEARAFAEARSEAESRFHAPKQSIQDIHIRKEQ
What are the official names of this protein?
Uncharacterized protein YxeC.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MED19_DICDI
Sequence: MSSSLYLINPIEKSSENITGETNLLEHFNLYKTLNEFNSKHLSSTYKSYVKNLPGDNYIKREKSKHSSSSSSNNNNNSNNNNNSNNTNASGQQDVNMGVPPQQQQQQQQQQQQQQPQQPQQPEPPKPPGGLTRLVEGNFFDENQQELILLSLDDSQLRSAFTLLDGGYQRPDKDKKRDKKHRDKKKRKHRDGSSSSSTSGEKKKSKKDRPDGSHHHSNSNNNNSGNSMNSNNMNNNNLNHNNNNNMNHNNMNHNNNMNHNNNMNNNMNNNNNNNNNNNNNNNNNNMNNNNNGGNITVEH
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Putative mediator of RNA polymerase II transcription subunit 19, Putative mediator complex subunit 19.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AMPD3_MOUSE
Sequence: MPRQFPKLNMSDLDEHVRLLAEKVFAKVLREEDSKDVMSLFTVPEDCPIGQKEAKERELQKELAEQKSVETAKRKKSFKMIRSQSLSLQMPTQQDWKGPPTASPAMSPATPLVPGATSKPGPAPYAMPEYQRVTISGDYCAGITVEDYEQAAKSLAKALMIREKYARLAYHRFPRTTAQYLAHQGESVPLEEGLPDFHPPPLPQEDPYCLDDAPPNLGYLVRMHGGVLFVYDNQTMLERQEPHSLPYPDLETYIVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKLGRKITLRQVFDSLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEDSKYQYSEPRLSIYGRSPKEWSSLARWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDLWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTK
What is the function of this protein?
AMP deaminase plays a critical role in energy metabolism.
What are the official names of this protein?
AMP deaminase 3, AMP deaminase H-type, AMP deaminase isoform E, Heart-type AMPD.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Protein: MTM1_HUMAN
Sequence: MASASTSKYNSHSLENESIKRTSRDGVNRDLTEAVPRLPGETLITDKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAKLSDPPTSPSSPSQMMPHVQTHF
What is the function of this protein?
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070).  Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414).  Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070).  Plays a role in vacuolar formation and morphology.  Regulates desmin intermediate filament assembly and architecture (PubMed:21135508).  Plays a role in mitochondrial morphology and positioning (PubMed:21135508).  Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508).  In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870).
What are the official names of this protein?
Myotubularin, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Late endosome. Cytoplasm, myofibril, sarcomere. Note=Localizes as a dense cytoplasmic network (PubMed:11001925). Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles (PubMed:12118066). Predominantly located in the cytoplasm following interaction with MTMR12 (PubMed:12847286). Recruited to the late endosome following EGF stimulation (PubMed:14722070). In skeletal muscles, co-localizes with MTMR12 in the sarcomere (By similarity).
Protein: CH19_DROSU
Sequence: MNTFATLAVLFCACLIGNCHGGYGGGGHGGYVQQGSYGQRSNGGAASAASSAAAAGNQRPVEIIAGGPRGGYGHGHEILRPIQLGYGGHSQRVPQHGSYGRRSGYGPRWTVQPAGATLLYPGQNNYRAYVSPPEYTKVVLPVRPAEPVAKLYIPENHYGSQQNYGTYAPQQSYNVEGPRY
What is the function of this protein?
Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.
What are the official names of this protein?
Chorion protein S19.
What is the protein family that this protein belongs to?
Belongs to the chorion protein S19 family.
What are the subcellular locations of this protein?
Secreted.
Protein: EFMT3_HUMAN
Sequence: MADPGPDPESESESVFPREVGLFADSYSEKSQFCFCGHVLTITQNFGSRLGVAARVWDAALSLCNYFESQNVDFRGKKVIELGAGTGIVGILAALQGGDVTITDLPLALEQIQGNVQANVPAGGQAQVRALSWGIDHHVFPANYDLVLGADIVYLEPTFPLLLGTLQHLCRPHGTIYLASKMRKEHGTESFFQHLLPQHFQLELAQRDEDENVNIYRARHREPRPA
What is the function of this protein?
Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner.  EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation.
What are the official names of this protein?
EEF1A lysine methyltransferase 3, Hepatocellular carcinoma-associated antigen 557a, Methyltransferase-like protein 21B, Protein-lysine methyltransferase METTL21B, eEF1A-KMT3.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL21 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: TATA_ALCBS
Sequence: MFSGISIWQLLILLAIVVLLFGTKKLRNIGGDLGGAVKGFKSAMKDGEDEQDHKRLADDDQPQNKQDAEQKAEQEKDKA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PYRE_ACIBC
Sequence: MTTPVSFHPQAFIELALSRGVLKFGEFTLKSGRVSPYFFNAGLLNDGEALSLLAQGYADKLTQCENVDVIFGPAYKGIPFVAATAVALSQTHNKSVPWGFNRKEAKDHGEGGVLVGAAVEGKKVWIIDDVITAGTAIREVVTILKNAGATIAGVLVALDRQERGQGELSAIQEVQKELEIPVHALITMKDLMDYLEAKGEKEALANMQAYREKYGI
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: STEA3_HUMAN
Sequence: MPEEMDKPLISLHLVDSDSSLAKVPDEAPKVGILGSGDFARSLATRLVGSGFKVVVGSRNPKRTARLFPSAAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLSDQLAGKILVDVSNPTEQEHLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAGPRDGNRQVPICGDQPEAKRAVSEMALAMGFMPVDMGSLASAWEVEAMPLRLLPAWKVPTLLALGLFVCFYAYNFVRDVLQPYVQESQNKFFKLPVSVVNTTLPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFCAALHALYSFCLPLRRAHRYDLVNLAVKQVLANKSHLWVEEEVWRMEIYLSLGVLALGTLSLLAVTSLPSIANSLNWREFSFVQSSLGFVALVLSTLHTLTYGWTRAFEESRYKFYLPPTFTLTLLVPCVVILAKALFLLPCISRRLARIRRGWERESTIKFTLPTDHALAEKTSHV
What is the function of this protein?
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.  Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+).  Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis.  Uses NADP(+) as acceptor.  May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression.  Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
What are the official names of this protein?
Metalloreductase STEAP3, Dudulin-2, Six-transmembrane epithelial antigen of prostate 3, Tumor suppressor-activated pathway protein 6, hTSAP6, pHyde, hpHyde.
What is the protein family that this protein belongs to?
Belongs to the STEAP family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.
Protein: CIP1_HUMAN
Sequence: MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRSPAICPACNSTLSGKLDIVRTELSPSEEYKAMVLAGLRPEIVLDISSRALAFWTYQVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTAPEPSNSFFSFVSPSRELEQQQVSSRAFKVKRI
What is the function of this protein?
E3 ubiquitin-protein ligase.  Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase.  Overexpression causes delayed entry into mitosis.
What are the official names of this protein?
E3 ubiquitin-protein ligase CCNB1IP1, Cyclin-B1-interacting protein 1, Human enhancer of invasion 10, RING-type E3 ubiquitin transferase CCNB1IP1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates to the synaptonemal complex.
Protein: PVK1_PANSB
Sequence: GSSGLIPFGRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, PanS2-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NPD_SALTI
Sequence: MQSRRFHRLSRFRKNKRLLRERLRQRIFFRDRVVPEMMENPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFARNPGLVQTFYNARRQQLQQPEIQPNAAHLALAKLEEALGDRFLLVTQNIDNLHERAGNRNIIHMHGELLKVRCSQSGQILEWNGDVMPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGSEFEEKHYGPASQVVPEFVDKFLKGL
What is the function of this protein?
NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins.  Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation.  Modulates the activities of several proteins which are inactive in their acylated form.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_TREPA
Sequence: MEVRGLQPKRQKTFARKHLVIVESPAKAQTIEKYLGTQYVVRASMGHVIDLPKSRLAIDIEHDFQPEYITVRGRAQCLKELRTLSKQSLQVFLASDRDREGEAIAYHLAQSIQAYCDTPIKRIVFNEITPHAIRAAIGHPVPIDTAKVNAQKARRVLDRLVGYHLCPLLWHKVKNGLSAGRVQSVALRLICEREVEVKRFVPEEYWTVEGTFEKDKKSFSALLILIQGKKAVFKSKQEATSAIGLFSQSEARVSQIRSFEKNVRPKQPFTTSTLQQCAANRLGFTSRKTMQVAQQLYEGVSLGTHRVGLITYMRTDSVRVSEAAVKEVRAWIATHFSDALPGTPNRYAAKGKSQDAHEAIRPTYVAHTPERIKAHLTRDQIRLYTLIWERFVASQMTDARVRSLTFEITAGPAVFSATETQVIEQGFYRVLKMLSPKDLSKAVLPPTKEGEVVALHNVQSVQHFTQGPVRYTDASIVKMLEEKGIGRPSTYAPTISVLLDRYYVTRIQKQLMPTPLGKVISDLLTTYFHDVVDVSFTARMESKLDEVEEDKIKWNCVIADFYPAFSEKVSTVMKDLNSMRGVFDEKTDVVCSQCGDTMVKKLGRFGFFLACGKFPECRNTQPVPLAKCPRPACDGNIVGKKTRGRKEFYGCTRFPVCDFVTHFKPTFAVCPQCRCFLVEKSNRRVGTYTACVNPECRYVSPTRKNLSLGKEAVLDGSHRGAQDKGAVQHYE
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: ASTER_DROME
Sequence: MNMTVDPRRKEKINRYKAPKNQGQSGGANEDMMPDYMNILGMIFSMCGLMMKLKWCAWFALYCSCISFASSRASDDAKQVLSSFMLSVSAVVMSYLQNPAAMTPPWAS
What are the official names of this protein?
Protein Asterix.
What is the protein family that this protein belongs to?
Belongs to the Asterix family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL34_SHIF8
Sequence: MKRTFQPSVLKRNRSHGFRARMATKNGRQVLARRRAKGRARLTVSK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: URK_LACJO
Sequence: MQSKRPIIIGIAGGSGSGKTTIAHEIYDQLQQDDHILIMTQDSYYKNNDNLSMADRKKINYDHPDAFDMPLLVEQLRQLMDYKAVEMPVYDFTAHTRSEKTIHTEPADIIILEGILVLGEENLRDLMSIKVFVDTDDDIRFIRRLERDTQERGRSVESVINQYLATVKPMYNQFIEPTKRYADIIVPEGGENDVAIDMLTTKIRSVLSTVK
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_DECAR
Sequence: MNWPALKERINLYEKLMRLDKPIGILLLLWPTLWALWLSALGRPNWIVVWIFILGTVLMRSAGCVINDYADRDFDKHVERTKERPLTAGKVTTKEALALFAGLSLLSFLLVVFLGNTLVIWLSLPAVFLAASYPFTKRFFAIPQAYLGVAFGFGIPMAYAAHLGEVPAEAWWLLLANVFWAVAYDTEYAMVDRDDDLKIGIKTSAITFGRFDVAAVMLCYGVTLAIIGGIGYSLNRGPAFYAGLAVATCIMGVHYTWIRGRERMPCFKAFLHNNWVGLSIFVGIVVDFLVSGRNLW
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LPXC4_ARATH
Sequence: MRLPVTVKATKPSFLVIWIRYSSAASSPTVSLNPSGRLQQTLAGSVEVKGKSLHSGKFSTVKLNPEIAGAGRFFEFRSRFIPASIEFAQESPLCTTLLKDELKIRTVEHLLSALEAKGVDNCRIQIESESSDDREVEVPIFDGSAKEWVDAIQGVGINAAQNHDGESVEKMVAHVNKPVYVCKNDTFVAAFPALETRITCGIDFPQVPAIGCQWFSWRPIHESSFAKDIASSRTFCVYEEVERMREAGLIKGGSLDNAIVCSAEHGWMNPPLRFDDEACRHKILDLIGDLSLVSRGGNGGLPVAHIVAYKAGHALHTDLARHLTMD
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell.  Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential).
What are the official names of this protein?
Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 4, mitochondrial, UDP-3-O-acyl-GlcNAc deacetylase 4, Protein LIPID X C4, AtLpxC4, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase 4.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NORA_ASPFN
Sequence: MVLPTAPEPPTLLGYHRILSSSAGVRVSPLCLGTMSFGNGWKGVMGECDQATSFNMLDTFYESGGNFIDVANFYQGGDSERWVGEWMAQRQNRDEIVLSTKYTMGYTMFGPQKIKSNYQGNHTKSLRLSVKASLQKLQTDYIDLLYVHMWDFTTSVEEVMRSLNHLVANGKVLYLGVSDTPAWLVVKCNAFARANGLTPFSVYQGHWSCAFRDFERDILPMCESEGMGLAPWGVLGRGQFRSAEDFSREGRKMGPQDEKHRRLGEKLDQMAQQKNTKATSIAQAYVMHKAPYVFPVIGGRKVEHLKENIEALGLVLSEEEIREIDDAEPFDVGFPMNFLFETPTQSYRTNMTSKDIWQLSCNTRLETVPKQQPIEPFQGAKYFGSASK
What are the official names of this protein?
Norsolorinic acid reductase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Protein: Y1154_ORYSJ
Sequence: MTVELEKIAGSFFISKGWKTFVHRTGLLSGQYIRFQVLTPSKINVLLFDKKKDSKLPMIPSSKKQIKTAPKRSTGITINDMPTSKHASMLISHTSNKETSSDSRTESMTDIPSSSDNSAVTPDIKNYISIIGQFLQRSSKFYIVTMNNTFMKQDRLVEAAGSDSVTMLLHKSSDDRCNLKRGWATFAATNAIHLHSVCIFHFYKAPNVKITIDVL
What are the official names of this protein?
Putative B3 domain-containing protein Os11g0625400.
What are the subcellular locations of this protein?
Nucleus.
Protein: YM13C_YEAST
Sequence: MWAGILEILSAFIRILFKLLYCWALFFTVLKGFSRGPLLPLIYLINKSL
What are the official names of this protein?
Uncharacterized protein YMR013C-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL22_CARHZ
Sequence: MEARAVAKYIRISPRKARQVIDLIRGKDVEEALAILRYTPKKASYFIEKVLRSAIANAENNHDMSKENLYVAKAYVDQGPTLKRYNPRAQGRVDLWRVRTSHITIVVAERKEG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: AL1A1_RAT
Sequence: MSSPAQPAVPAPLANLKIQHTKIFINNEWHDSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLLLATIEAINGGKVFANAYLSDLGGSIKALKYCAGWADKIHGQTIPSDGDIFTFTRREPIGVCGQIIPWNFPLLMFIWKIGPALSCGNTVVVKPAEQTPLTALHMASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVRKSVERAKKYVLGNPLTQGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSIDDVIKRANNTTYGLAAGVFTKDLDRAITVSSALQAGVVWVNCYMILSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS
What is the function of this protein?
Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:7832787, PubMed:15623782).  Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid.  This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (PubMed:7832787).  Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic.  By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:15623782).  Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity).  Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
What are the official names of this protein?
Aldehyde dehydrogenase 1A1, 3-deoxyglucosone dehydrogenase, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic, Retinal dehydrogenase 1, RALDH 1, RalDH1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell projection, axon.
Protein: DRE2_AJEDR
Sequence: MASTGRVLLLSPPSLSSHPEKLNAILGSHTRDRTDLQMLDRLVHGLVSLPASTYDIVLLLTGADNTLAEPYSLVTRDIIQQVVHSLKPAGKLRSQDNKAWGLRSSGNNSDDDNDNDELTFRNEAILAGLVFDDNGELLKPDVAAQQAVPLKLGRRKKEKERRHPSGNDVTNGKVNAPSSNGVNASTSTATATATTTTTTTPKTNPAPSGVGFIDFSDDYGVPMEEDPQGSDDELIDEDELLGEDDMGRPIVQPPECRPKPGKRRRACKDCSCGLSQKLEAEDKAKRATADKALETIMAPTMKLGSSELAEVDFTVQGKVGSCGNCSLGDAFRCDGCPYIGLPAFKPGEEVRLLNNDVQL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein DRE2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: SURF6_TAKRU
Sequence: MDLASKDSYIQRLASKVISQPDQERKKKQFAYPQGKRYNGPLNNNKKKGNRKSFKEKDTRGKTPGFPKKSLSSIQPTQKGAANKNGQKAQTQSINGSSTQALEGGNESKFSTVDILRKRLHEKIEESRGQGAPKDALSEAVQAKRAKRKLERERKKRKRKEFRMKELAQQNVEEQQPELKPKAVCESAATKRNVQAIIFNKVEMVEEGYVDKVQKKKNKKQSMKGNITPLTGKNYKQLLSRVEARNAKLEGLREKDEAKARDLEEKIKWTNLLYKAEGIKIKDDEEMLRTALKKKEQKRAQRKKKWAELSGNLAEKMQQRQDKRTRNIQKRKQLKTEKKKNKARKKGRVLPEDLKKAAV
What is the function of this protein?
Involved in a nucleolar function.
What are the official names of this protein?
Surfeit locus protein 6 homolog.
What is the protein family that this protein belongs to?
Belongs to the SURF6 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.