PharMolix/UniProtQA huggingface dataset:
Protein: KES1_SCHPO
Sequence: MSKTTSSDDSRDGEGDKRLRSTTKSTWLSFLKSIATFSGDLSSLTAPSFILSSTSLIEYSAYWAEHPELFISLPRGETPLERQLLVTKWFASTLKNQYAARNERYGSEKKPLNPILGELFTGKWNTDIGEDTELTSEQVSHHPPITAYHIYNKKAGVRLEGYNGHKSGFSGPQIHVKQIGHARLILEPHNEVYYITFPLVTLEGLWYGSPYIELGKKSYIISTSGYLTTIEYSGKGYFTGKKNTFKATIVNAKTKSEPIYRIEGSWTGMLKYCTFEDQKRSAWEDFLDCGNYKPVNISVAPIEEQGEYESRRVWKNFAVALDAGDYAAASQEKSKIEEGQRELRRQEEEHNEVWHRKYFEWKDKDEGFEEATKCLRQPVKEGFWYYLR
What is the function of this protein?
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum.
What are the official names of this protein?
Protein kes1.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
Protein: TPIS_LACDE
Sequence: MSRTPIIAGNWKLNMNPKETVEFVNAVKDQLPDPSKVESVICAPAVDLDALLKAAEGSNLHVGAENCYWENSGAFTGETSPAVLKEMGVQYVIIGHSERRDYFHETDEDINKKAKAIFANGLTPILCCGESLETREAGKENEWVVSQIKAGLEGLTSEQVSKLVIAYEPIWAIGTGKTASSDQAEEMCKTIRETVKDLYNEETAENVRIQYGGSVKPANVKELMAKPNIDGGLVGGASLVPDSYLALVNYQD
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_STRT2
Sequence: MANVKLFDQTGKEVSTVELNDAIFGIEPNESVVFDVVISQRASLRQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLPQKVRRLALKSVYSAKVAEDKFVAVEALSFAAPKTAEFANVLSALSIDSKVLVIVEEGNKFAELSARNLANVTVATPATASVLDIVNADKLLVTKEAISSIEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: MNHA1_STAA9
Sequence: MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVLGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit A1, Mnh complex subunit A1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SCPB_BACC1
Sequence: MDRTEQKSIIEGLLFVSGDEGISPEQIAKVLEIEGNEVIDILEEMQKECEGAHRGLQIVQYAKVYRFATKKEHASYYQKLIDIPTAASLSQAALETLAIVAYRQPITRTEMEEIRGVKTDKALQTLVSHLLIKEMGRAEGPGRPILYGTTKEFLDTFGLKTLDDLPPLSEENEQMNEADLFFGSLQEISK
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: NEUL3_RAT
Sequence: MGSRLSPEANAEVPREALSFHGDATGAQVHLDDQRSTARRRSTFHDGIVFSQRPVWPGERVALRVLRHEDGWCGGLRVGFTRLDPAQVAASCLPPFVCPDLEEQSPTWAALLPEGFVRAGNVVCFWVNRRGWLFAKVNAGRPLLLRKDVLVQGAPLWAVMDVYGTTKAIELLDPKANAWITSGEPMPESEVTSGEECVICFHNTANTRLMPCGHSQFCGSCAWHIFKDTARCPMCRWQIEEVAVEPSVKSGEGS
What is the function of this protein?
E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity.  Seems to utilize UBE2E1.  Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7.  Inhibits also hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2.
What are the official names of this protein?
E3 ubiquitin-protein ligase NEURL3, Lung-inducible neuralized-related C3CH4 RING domain protein, Neuralized-like protein 3, RING-type E3 ubiquitin transferase NEURL3.
Protein: RL23_CAMJE
Sequence: MADITDIKTILYTEKSLNLQEQGVVVIQTSPKMTKTGLKAVLKEYFGVTPKSINSLRMDGKIKRFRGRLGQRNNYKKFYVKLPEGVSLENTEA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: HSLU_ALIFM
Sequence: MSEMTPREIVHELDSHIIGQDKAKRSVAIALRNRWRRMQLAPELRTEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVESIIRDLTDVAIKMTHQQAVEKVKFRAEEHAEDRILDILLPPARDAWGNNEEGDNDSGTRQSFRKKLREGKLDDKEIEVDVAAPQVGVEIMAPPGMEEMTNQLQGMFQNLSGGNTTKKRKMKIVDALKALTEEEGAKLVNPEELKEQAIFNVENHGIVFIDEIDKICKGSNSHSGDVSREGVQRDLLPLVEGSTVSTKHGMVKTDHMLFITSGAFQMAKPSDLIPELQGRLPIRVELEALTANDFKRILTEPNASLTEQYIALLATENVKVEFTEDGISRIAESAFQVNETTENIGARRLHTVMERLMEEISYDASEKNGESLIVDAEYVSSRLGELVADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDA15_ARATH
Sequence: MVVETIERSCEGSKRRHVNGGDIAVPCSGEECSNGDINVAPGVSAKRARVSREMTFEDIYGADALLNDDDDEDDDCDWEPVQAPMEFVKWCCVNCTMSNPGDMVHCCICGEHKESGILRHGYLASPFFKDTGLIEVEEKYGGSSSATSSTAVGFDERMLLHSEFEVKAQPHPERPDRLRAIAASLATAGVFPGRCLPINAREITKQELQMVHTSEHVDAVDTTSQLLYSYFTSDTYANEYSARAARLAAGLCADLATDIFTGRVKNGFALVRPPGHHAGVRHAMGFCLHNNAAVAALVAQAAGAKKVLIVDWDVHHGNGTQEIFEQNKSVLYISLHRHEGGNFYPGTGAADEVGSNGGEGYCVNVPWSCGGVGDKDYIFAFQHVVLPIASAFSPDFVIISAGFDAARGDPLGCCDVTPAGYSRMTQMLGDLCGGKMLVILEGGYNLRSISASATAVIKVLLGENPENELPIATTPSVAGLQTVLDVLNIQLEFWPSLAISYSKLLSELEARLIENKKNQMKRKVVRVPTWWKWGRKKLLYNFLSARMISRSK
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:23548744).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:23548744).  Histone deacetylases act via the formation of large multiprotein complexes (Probable).  Represses chlorophyll biosynthesis and photosynthesis in the dark (PubMed:23548744).  Is recruited by PIF3 to the promoters of chlorophyll biosynthetic and photosynthetic genes, and represses their transcription by histone deacetylation (PubMed:23548744).  Involved in the repression of hypocotyl cell elongation to promote photomorphogenesis (PubMed:31061103).  Is recruited by HY5 to the promoters of a subset of cell wall organization and auxin signaling-related genes, and represses gene expression by decreasing the levels of histone H4 acetylation in a light-dependent manner (PubMed:31061103).  Promotes abscisic acid (ABA) signaling (PubMed:30979883).  Is recruited by MYB96 to the promoters of a subset of Rho GTPase (ROP) genes, which repress ABA signaling at the early stages of signal transduction (PubMed:30979883).  Represses ROP expression by removing acetyl groups of histone H3 and H4 from the cognate regions, particularly in the presence of ABA (PubMed:30979883).  Represses the plant response to elevated ambient temperature by directly repressing warm temperature-responsive genes (PubMed:31400169).
What are the official names of this protein?
Histone deacetylase 15.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles in and out of the nucleus upon light exposure. In the absence of light, is exported out of the nucleus, and upon further exposition to light is imported to the nucleus.
Protein: HPPA_ANAMA
Sequence: NGSIMGALYKGLIATGLLSIVGLGVANTLTVGWGEIGTVAGKSITGTNLFVCGLIGLIVTGLIVVITEYYTGTNKRPVNSXAQASVTGHGTNVIQGLAVSLESTALPAIVIVGGIIXTYQLAGLFGTAIAVTAMLGIAGMI
What is the function of this protein?
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane.  Generates a proton motive force (By similarity).
What are the official names of this protein?
Pyrophosphate-energized proton pump, Membrane-bound proton-translocating pyrophosphatase, Pyrophosphate-energized inorganic pyrophosphatase, H(+)-PPase.
What is the protein family that this protein belongs to?
Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AATPE_ARATH
Sequence: MSDYWTTMASLLGMLAFCQTIVQLVFPPELRLAFLHFLTRIRHVFSSHIYFDITEIDGVNTNELYNAVQLYLSSSVTVNDAVSSSNNNTRLSLTRVPNSSSVTFGLSNNDRITDVFNGVTILWEHVVVQRQVQSFSWRPMPEEKRGFTLQINKRDKALVLDSYLDYIVGKSEEIRRRNEERLLYTNSRGVSLDARSHPWDSVRFKHPSTFDTLAMDPEKKKRIMEDLREFANGQGFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQNNSELRKLLMKTSSKSIIVIEDIDCSISLTKRGKNKKKNGSYEYDPGLTNGSGLEEPGSSVTLSGLLNFTDGLWSCCGSEKIFVFTTNHIEKLDSALMRSGRMDMHVHMGFCKFPALKILLKNYLRLEEEDMDSVVLKEMEECVEEAEITPADVSEVLIRNRSDAEKAVREIVSVLKERVVKRRKSVGLKKKKQEGQEEEEEAEEEQEKRALDSPNRRNREVCGFREEEEEEDEKEK
What are the official names of this protein?
AAA-ATPase At4g30250.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. BCS1 subfamily.
Protein: UMPS_ARATH
Sequence: MSAMEALILQLHEIGAVKFGNFKLKSGIFSPVYIDLRLIVSYPSLLTQISQTLISSLPPSATFDVVCGVPYTALPIATVVSVSNGIPMLMRRKEIKDYGTSKAIEGIFEKDQTCLIIEDLVTSGASVLETAAPLRAVGLKVSDAVVLIDRQQGGRENLAENGIKLHSMIMLTDMVRVLKEKGKIEVEVEVNLLKFLEENRRVSVPSVEKPKPKPRVLGFKERSELSKNPTGKKLFDIMLKKETNLCLAADVGTAAELLDIADKVGPEICLLKTHVDILPDFTPDFGSKLRAIADKHKFLIFEDRKFADIGNTVTMQYEGGIFKILEWADIINAHVISGPGIVDGLKLKGMPRGRGLLLLAEMSSAGNLATGDYTAAAVKIADAHSDFVMGFISVNPASWKCGYVYPSMIHATPGVQMVKGGDALGQQYNTPHSVITERGSDIIIVGRGIIKAENPAETAHEYRVQGWNAYLEKCSQ
What are the official names of this protein?
Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the OMP decarboxylase family.
Protein: RS10_WOLPP
Sequence: MKQDIYIRIKAFDCSLLEKCIREFIDQLKQFNADLSGPIALPRKDSKFTVNRSPHVDKKSREQFEMRISKRLIIVHNPTSTMMKMLADLSFSAGVEVDLKVKEVNI
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: SLAA_SACS2
Sequence: MNKTLGLILTSVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNATSNSTVGAQASAFNYGLAINYTLDAITFTVVLPSGTSYPLIKLNAKNFANYGYYDLAHNSIVLLLNTTASSTAKELAYSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNELPLSMLIYMATNGKYNNLASLPVGTKLEFTYAGVTYIIAVSPTVKLVGELLNPLYTANSKMLPGTNYAVGRSNITVAVYDNLITTTTSPFNFTLTYSSLAPALIYWFVIANTTYTNNGASTPTASFQAPPFKQYFPSNSTILYSAAPTKSSILMFNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGDNNGATVIYNGVSLNTGFPQVVVMFNITGNFTKSGSNYLLYGSVYEAELKPLGSTQLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVERLGYIYLVTFHIWGPSATVTVTGVDYHGTQIALGSFRAYVALPSFYTLPKTPLVGLTCDNMYTLAQVSDAGSVLETSTANSNANNATVIGPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQTVALTYSSAPTAIYPVDFKFEPGFSYSVTTNVIYNTSIPTYVVTVYMPLKYILQTKIVMWYVSPDYAAYFYYSSTGQYQTSNVTLTFANVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQSGVIEAVENGFNVGNITSITVELNGMNESIVLSPLNVSKLLISSNLGEVSQCSPLFTTTLFNISALASLLGLPNAAALNGSYLYVTYHDIISGAYVTNRTLLVVGQFYVMPPTTPGSVEWILTAKYINATTGIPVEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNASTIVYMNGMFVASYGGNLISSLSETSTFGVYYGAVVNLYVATGTLSSPNGTMYVVLGSHKVAVGTANLYTYAGYHFGPYTALPLVSNVTFTVQDPVTHATLTGQTTLGAFNNTPIRLAPLGVSIPQTAQYKVFYYYSTPLVLSPTSQYIVLSVTSVISYPYPFYIETVSFLGYNVTTGTPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLVYANVTAISS
What is the function of this protein?
S-layer large protein.  May form the highly ordered outer sheath.
What are the official names of this protein?
S-layer protein A, Surface layer large protein.
What is the protein family that this protein belongs to?
Belongs to the Sulfolobales SlaA family.
What are the subcellular locations of this protein?
Secreted, cell wall, S-layer.
Protein: CH10_ALIFM
Sequence: MNIRPLHDRVIVERQEVESKSAGGIVLTGSAAEKSTRGTVLAVGKGRILENGTVQPLDVKVGDSVIFAEGYGTKSEKIDGKEVLIMSENDIMAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNHI3_HUMAN
Sequence: MASLKCSTVVCVICLEKPKYRCPACRVPYCSVVCFRKHKEQCNPETRPVEKKIRSALPTKTVKPVENKDDDDSIADFLNSDEEEDRVSLQNLKNLGESATLRSLLLNPHLRQLMVNLDQGEDKAKLMRAYMQEPLFVEFADCCLGIVEPSQNEES
What are the official names of this protein?
Zinc finger HIT domain-containing protein 3, HNF-4a coactivator, Thyroid hormone receptor interactor 3, Thyroid receptor-interacting protein 3, TR-interacting protein 3, TRIP-3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LYNX1_PANTR
Sequence: MTPLLTLILVVLMGLPLAQALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNGAGLATPATLALAPILLATLWGLL
What is the function of this protein?
Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs).  The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration.  Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization.  Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs.  Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum.  Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR.  In vitro modulates alpha-3:beta-4-containing nAChRs.  Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode.  Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs.  Prevents plasticity in the primary visual cortex late in life.
What are the official names of this protein?
Ly-6/neurotoxin-like protein 1.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Cell projection, dendrite. Endoplasmic reticulum. Note=Detected in Purkinje cells soma and proximal dendrites.
Protein: SPG4_YEAST
Sequence: MGSFWDAFAVYDKKKHADPSVYGGNHNNTGDSKTQVMFSKEYRQPRTHQQENLQSMRRSSIGSQDSSDVEDVKEGRLPAEVEIPKNVDISNMSQGEFLRLYESLRRGEPDNKVNR
What is the function of this protein?
Stationary phase-essential protein not required for growth on nonfermentable carbon sources.
What are the official names of this protein?
Stationary phase protein 4.
What is the protein family that this protein belongs to?
Belongs to the SPG4 family.
Protein: ZSWM7_MOUSE
Sequence: MAVALPEVVEELLSEMAAAVRDSARIPDELLLSLEFVFGSSAIQALDLVDRESVTLISSPSGRRVYQVLGSSGKTYTCLASCHYCSCPAFSFSVLRKSDSLLCKHLLAIYLSQLLRNCQQLHVSDKQLTDLLMEDTRRIKGAAGTWTSKTEA
What is the function of this protein?
Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents (By similarity).  Required for meiotic progression, hence for fertility (PubMed:33713115).
What are the official names of this protein?
Zinc finger SWIM domain-containing protein 7, SWIM domain-containing and Srs2-interacting protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SWS1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLMM_LACCB
Sequence: MTKYFGTDGVRGIANKELSPEMAFRLGRTGGYVLTQHKEDASRRPLVLVARDTRISGQMLADALIAGLLSVGIEVLDLGVITTPAVAYLIKIQGADAGIQISASHNPVADNGIKFFGADGYKLSDDTEEEIEALLDAPEDKLPRPAAEGLGTVDDYPEGALKYTQFLEQTLADDLSGIHVCLDGANGATSGLVSRIFADLETDFDTMAISPDGLNINANVGSTHPQALSKFVVEKGADVGLAFDGDGDRCIAVDEQGNIVDGDKIMFILGSYMKSQGRLKQDTVVTTVMSNLGLYKALEANGMKSVQTAVGDRHVVEAMRKDGYNIGGEQSGHVILFDYHNTGDGMLTGIHLLNVMKKTGKKLSELAAPVQDYPQKLVNVKVADKENWQAYPEIQSAIDTVEKEMAGDGRVLVRPSGTEPLLRVMAEAKTEDLVSRYVDQIVDVVKQEMGSKED
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: ISPH_DEHMB
Sequence: MKVECASNIGFCFGVHRAINILEKTASERGGVETLGALVHNQQVLNRLSGMGVRVVKNIDDISGRTVAISSHGVGPAVLAELKSKGLEIVDTTCPFVKRAQVAAKRFHDAGFFTVIYGDVNHPEVKGILGWAGGNGLATLNPQGLDDIPDLSRYIGVLSQTTQIPTGFTSFVKNVIDQALVKDAEIRIADTLCHDIRDRQAAALELAGRVDLMLVIGGHNSANTRHLLDLCKTVSNTHLIETASELQTDWLKGVSRIGITSGASTDETTISEVCSYLDRLSAGA
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: VRTR2_PENAE
Sequence: MPSLSSKTSTMQRSCRPQMSACPNQQQKDRPVPQLSCVLCRDRKLKCDKLDPCSNCTSSGVACTPIYRPRLPRGRHARTVQTKASTPPDTRRRGSSNESTTAPAPDDGGLGTHIDQLDNLVQDREVSKLGLSGEGNGLQELISLVSDETMPATAWSTHCFGTISRILSSRIRRLESLVQETARIQTPKRARKPMTPVVVQWYSAPLAGCNWNRMVVQTPQGLEVQQFPAPPTSYSARRSPELSGNDIWADLMDHDMHDPPQYNALELPPDLTNEGGVDNMGSSGRDDPINNGFNALRLLGINNSLSPSFISLPRDRLSASKLCQVYLQNVDPIIKILHRPSLSRWMVDGAPTYLGSSEDDYAVKALESAVCYTAANTMTEHQCQAAFQKTKSSIMAVRRKMCEDALENAGLLTTRDMTVLQAFILYLVTPTDLSKIGRRSEDKDTAVWALVALAIRLIKAMGLNQEPSEGARKGESFFQQQLRLRLWLTACLIDLQASFAQATDPLITHRDAACAVPYVANINDSDFDVDTAHPVASHEELTDTTFALVTYRVQVAGRLFNFGPGCSTAAERHKLAQEVQQQVFTLLHYCDPESSSYAWFTWHSTQSIIFAVRLSELLPFRCGQPGGHVPPPSPRAEGDTTLLWRALQNLEKAQLIRADPRGDGFRWYITTPWLALSTAISECNSCTDVALVCRAWPVIEISYRQHEELQISDECQLPQGPLVHLMNKTREKLAPLLQEGGARLSDSQTVDRASADSLQPPVPVGSIPIDPLLTNGSLGADTAMSEASSIGSLPPFEQQCWKQMTMPTDGAPVRDGVVFTSELYNPLQSDFLNSHG
What is the function of this protein?
Probable transcription factor that regulates expression of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system (PubMed:20534346).
What are the official names of this protein?
Transcription factor vrtR2, Viridicatumtoxin synthesis protein R2.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZAPB_SALPC
Sequence: MSLEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNSLTQEVQSAQHQREELERENNSLKEQQSGWQERLQALLGRMEEV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid-cell, in a FtsZ-like pattern.
Protein: C5I4_HYARU
Sequence: MSAFNIFALVVVVCALMINECCTSQEPTTPLKAASQCSNVKCRRRFDHLGNSVTEGCPSGCLCVYQATGYNQEANGTCYELMKTSTTTTTEGTPAQ
What is the function of this protein?
Complement inhibitor (PubMed:27018802).  Prevents complement-mediated C5 activation by binding to C5 (PubMed:27018802).  Binds C5 at a different binding site than the other tick complement inbibitors OmCI and CirpT1, and the drug eculizumab (By similarity).  Inhibits complement in human and guinea pig but not in other species tested (rabbit, rat, mouse, and pig) (PubMed:27018802).
What are the official names of this protein?
Complement inhibitor RaCI4.
What is the protein family that this protein belongs to?
Belongs to the RaCI family.
What are the subcellular locations of this protein?
Secreted.
Protein: R31B2_STRCO
Sequence: MRKGIHPEYRPVVFRDRAADYAFLTRSTMTSERTVEWEDGRTYPVVDVEVSHVSHPFYTGTARVLDTAGRVERFERRYGKQDGA
What are the official names of this protein?
50S ribosomal protein L31 type B 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: GPI10_SCHPO
Sequence: MRIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAARFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPCHTTPWQSHIHSPFAENGWKFLTCEPFEKPFDETDRFYENMPTFLDKIKEWPDYLIFFEERFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVYKKL
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 3, GPI mannosyltransferase III, GPI-MT-III, Glycosylphosphatidylinositol-anchor biosynthesis protein 10.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 22 family. PIGB subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.