PharMolix/UniProtQA huggingface dataset:
Protein: CARB_MYCBO
Sequence: MPRRTDLHHVLVIGSGPIVIGQACEFDYSGTQACRVLRAEGLQVSLVNSNPATIMTDPEFADHTYVEPITPAFVERVIAQQAERGNKIDALLATLGGQTALNTAVALYESGVLEKYGVELIGADFDAIQRGEDRQRFKDIVAKAGGESARSRVCFTMAEVRETVAELGLPVVVRPSFTMGGLGSGIAYSTDEVDRMAGAGLAASPSANVLIEESIYGWKEFELELMRDGHDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAILREVGVDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDEIVNDITGETPACFEPTLDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSLGRNFVEALGKVMRSLETTRAGFWTAPDPDGGIEEALTRLRTPAEGRLYDIELALRLGATVERVAEASGVDPWFIAQINELVNLRNELVAAPVLNAELLRRAKHSGLSDHQIASLRPELAGEAGVRSLRVRLGIHPVYKTVDTCAAEFEAQTPYHYSSYELDPAAETEVAPQTERPKVLILGSGPNRIGQGIEFDYSCVHAATTLSQAGFETVMVNCNPETVSTDYDTADRLYFEPLTFEDVLEVYHAEMESGSGGPGVAGVIVQLGGQTPLGLAHRLADAGVPIVGTPPEAIDLAEDRGAFGDLLSAAGLPAPKYGTATTFAQARRIAEEIGYPVLVRPSYVLGGRGMEIVYDEETLQGYITRATQLSPEHPVLVDRFLEDAVEIDVDALCDGAEVYIGGIMEHIEEAGIHSGDSACALPPVTLGRSDIEKVRKATEAIAHGIGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKATAVPLAKACARIMLGATIAQLRAEGLLAVTGDGAHAARNAPIAVKEAVLPFHRFRRADGAAIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAQGTVFVSVANRDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCDDVRKHFEPAQPGRPTMSAVDAIRAGEVNMVINTPYGNSGPRIDGYEIRSAAVAGNIPCITTVQGASAAVQGIEAGIRGDIGVRSLQELHRVIGGVER
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: RUVB_CLOBK
Sequence: MENRMVTPFDVEDDREQYSLRPTTLKEYIGQKKVKANLDIFIKAAKKRSESLDHVLFYGPPGLGKTTLANIIANEMTGNLKVTSGPAIEKAGDLAAILTSLTDYDVLFIDEIHRLNRSIEEILYPAMEDYALDIVIGKGAAAKSIRLDLPKFTLIGATTRVGLLTSPLRDRFGMLCAMEFYTDEELMEIVVRSAAILNVNICREAAFEIGKRSRGTPRIANRLLKRVRDYCDVKHDGDIDLQGAKAALDLLEVDKEGLDKIDNKILEAIIFNFKGGPVGLETLAYFIGEELDTIEDVYEPYLIQKGFIMRTPRGRVASEKAYNHFGVTKKEEKDNQVSIFNK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: NSP6_ROT41
Sequence: MNHRQQRQLFLENLLVGMNCMFHQMQKRSINTCCQNLQKILDRLILLQTIHSPAFRLDRMQLRQMQTLACLWIHQHNHDHQVMLGAIKWISPLTKQ
What are the official names of this protein?
Non-structural protein 6, NSP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus A NSP6 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host mitochondrion. Note=Found in spherical cytoplasmic structures, called viral factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RS21_MYCPN
Sequence: MPKIEVKNDDLELALKKFKRVSLEIRRLAQRHEYHLRKGMRLREKRKIAQKKRRKFRNMV
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RS2_LIMF3
Sequence: MPVVSMKQLLEAGVHFGHQTRRWNPKMKPFIFTERNGIYIIDLQKTVKMIDTAYNYVKDVAADGGVVLFVGTKKQAQDSIEEEATRAGQYYVNHRWLGGTLTNWKTIQSRISRLKELKKMAEDGTFDRLPKKEVAVLTKQREKLERFLGGIEDMPRIPDVLYIVDPHKEQIAVKEAQKLHIPIVAMVDTNTDPDDIDVIIPSNDDAIRAVRLITAKMADAVIEGKQGEDDQQVAPAEDVAEEVSDESLQDLKNSVEGND
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: 1433F_BOVIN
Sequence: MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLALLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEHMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner.  Negatively regulates the kinase activity of PDPK1 (By similarity).
What are the official names of this protein?
14-3-3 protein eta, Protein kinase C inhibitor protein 1, KCIP-1.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_CUTAK
Sequence: MTDVNPVRSDNCRQYNNVPPQIDLPAMDHEIIDLWARQHTFDKSLEATKDGQPWTFFEGPPTANGQPGTHHVEARVFKDIFPRFKTMQGFRVDRKAGWDCHGLPVELAVEKELGFSGKPDIEKYGVEPFNAKCRESVTRHVDAFSELTERMGYWVNMDEAYWTMSPSYVESVWWGLKRIWDKGLLGEDHRVAPYCPRCGTTLSDHELAQGYQDDRDPSIYVRFPVTSGPLAGRAKLLVWTTTPWTLVSNTAVAVHPEVRYVVAHRDPVPEGSDAVATASAEDPASQDLIIAEPLFEKVLGEGWSLTGESFLGSQMELWTYERPYNFLEWPKTERVTVDGRPTPADANFVVLADYVTVEDGTGLVHQAPAFGADDLQTCRRYGLPLVNPIRPDGTFEESVPLVGGQFFKTADKPLCEDLDRRGVLFRLEMHWHSYPHCWRCDTHLIYYAQPSWYIRTTKVKEQLLAQNEVTTWYPETIKHGRFGDWLENNIDWAVSRSRYWGTPLPLWRNDDDRSDVICVESLAELSQYVGRDLTGMDPHRPFIDEVTFTRDGHTYHRVPEVADAWLDSGSMPFAQWGYPHVPGSKEKFESHYPGDFICEAIDQTRGWFYTMMAVGTLVFDESSYRNVLCLGHILAEDGRKMSKHLGNILLPIPLMDSHGADALRWFMAADGSPWSARRVGDETIQETVRKVLLTYWNTVSFQVLYARANGWSPAQGTQHDADPARGFGGVVPPAVGSRGFGGVVPPAVTERHVLDRWLVSATNVLVRDVTEALNNFDTQRVGNLIAQFVDELSNWYVRRSRRRFWDGDEGALWTLHETLETLTKLMAPMVPFITERVWQDLFVTTNPHGPESVHLASWPVADDSLIDESLSESMDLARRIVELGRGARAEAKAKIRQPLSRALISGAALAKLDEDLQAEIRSELNVMALDSFTAAGDLVDHCAKGNFRALGKKYAKATPKVAAAIAAADPEWLASELAIKGSVEMDVPEVEGGKAVVTADDVIVSERPREGWSVVNEQGETVALDLEITPELARAGQAREVIRFVQDSRKKAGLDVSDRITLAWSASADLATAIEEHAEQISQEVLAVQMSREPRADDWAVEPDLGLAVKVVKV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPE_ECOHS
Sequence: MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTAKTAAVLAPLGVSVTGIHSVVDPVAAIENAEIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEAGHRF
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BACD_BACSU
Sequence: MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASHAALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGADAITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTTLEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVTFEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSHITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNMIPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPETAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQDVAESIRQIQQHAKLTAKYVLPV
What is the function of this protein?
Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase.  Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP.  In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide).  The substrate specificity is restricted to small amino acids such as L-Ala, for the N-terminal end of the dipeptide, whereas a wide range of hydrophobic amino acids such as L-Phe, L-Tyr and L-Met are recognized for the C-terminal end.
What are the official names of this protein?
Alanine--anticapsin ligase, ATP-dependent dipeptide ligase, Bacilysin synthetase, L-Ala-L-amino acid dipeptide ligase, L-alanine--L-anticapsin ligase, L-amino acid ligase, Lal.
Protein: SPEE_DESAP
Sequence: MHLWFTEKQNDNFAISYRVNETLHTETTPFQHLAVLDTVPFGRTLVLDGIVQTSVVDEYVYHEMITHVPLNTHPDPRRVLIVGGGDGGTLREVTKHPSVEKATLVEIDERVIAASKKYLPELACGFDSPKAEVVIGDGIKYVAEHKKTFDLVIVDSTDPIGPAVGLFSLEFYRSIYEALKDEGLFVAQTESPYFNTDLILRIYRDIAGIFPLARTYWACIPTYPGAMWSFTIGSKKHDPAQVAPEKIREHATRYYTPEIHRASFAMPRFLADRFR
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_TAMMR
Sequence: MTNIRKTHPLIKIINHSFIDLPAPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTYFETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVMVHLLFLHETGSNNPSGLISNSDKIPFHPYYTIKDILGILLLILALMTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILMLFPILHMSKQRSMMFRPLSQCMFWILVADLFTLTWIGGQPVEYPFIIIGQLASILYFTIIILILPAISLFENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CXL16_HUMAN
Sequence: MGRDLRPGSRVLLLLLLLLLVYLTQPGNGNEGSVTGSCYCGKRISSDSPPSVQFMNRLRKHLRAYHRCLYYTRFQLLSWSVCGGNKDPWVQELMSCLDLKECGHAYSGIVAHQKHLLPTSPPISQASEGASSDIHTPAQMLLSTLQSTQRPTLPVGSLSSDKELTRPNETTIHTAGHSLAAGPEAGENQKQPEKNAGPTARTSATVPVLCLLAIIFILTAALSYVLCKRRRGQSPQSSPDLPVHYIPVAPDSNT
What is the function of this protein?
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity).  Induces a strong chemotactic response.  Induces calcium mobilization.  Binds to CXCR6/Bonzo.
What are the official names of this protein?
C-X-C motif chemokine 16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, SR-PSOX, Small-inducible cytokine B16, Transmembrane chemokine CXCL16.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Secreted. Note=Also exists as a soluble form.
Protein: Y1342_METJA
Sequence: MLWVLGGKKIAKCLKETVNPKEIEDKELIKFLINFCDMCNDFVIDDEKIGIKIDKCKYCPKQIGEAEIPGSACPIPSILASCMRELTKKDYKINLWDGNKVIIKENGYCWFRIK
What are the official names of this protein?
Uncharacterized protein MJ1342.
Protein: RL17_SERP5
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEIVAKLFNELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRAESQAEVATAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: PHSG_HAEIN
Sequence: MIMDNFDSPFQYNRPEMTVEAIKKSIVYKLIFLIGRSPREASQRDWLNATLHAVRDLVTEGWITTARQTRAEDSRRVYYLSMEFLIGRTLSNAMIAEGIYGLAQEALSELNVDLEEVLEKEVDPGLGNGGLGRLAACFMDSIATLGLPGMGYGIRYEYGMFRQKIENGQQVERPDAWLEKGAPWEFIRPSKRFTVEFGGNIHFEGKKCIWQDTEKVTALAYDQMIPGYQNNSAATLRLWSAHAGEVFNLADFNRGEHLAALEEHSANKNLSRVLYPDDSTWNGRELRLRQEYFLVSASLQDILRRHKRTHNSLENLADKVAIHLNDTHPALAIPELMRILVDDEGFEWKKAWEMTRNIFSYTCHTLMSEALETWPVEMMAKILPRHLQMIFEINDHFLEYVRTYVTTDNDFIRRVSLIEEGYQRKVRMGWLSVVGSHKINGVAEIHSDLMVTSTFADFARIFPERFTNVTNGITPRRWLAVANPQLAALFDKYIGSEWRCDLSQIEKLKPFAQEKAFKEAVADIKFANKVKLAEYVKSELGVELDPHALFDVQVKRIHEYKRQMLNVLHIIARYNEMLTNPEKDWQPRVFILAGKAASAYYAAKQTIHLINDVANVINNDERLKGRLKVVFIPNYSVSLAQLIIPAADISEQISLAGTEASGTSNMKFALNGALTLGTLDGANVEILENVGEDNIFIFGNTVEQVEQLRREGYRSFEYYQNDAQLRTVVDQIIEGKFSPEDPQRYHQLLQGLQYHDYYQAFADFRSYVETQKAVDEKYKQRDQWIESTIQNIVNMGFFSSDRTIKEYAERIWKVEPVQLGD
What is the function of this protein?
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism.  Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates.  However, all known phosphorylases share catalytic and structural properties (By similarity).
What are the official names of this protein?
Glycogen phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the glycogen phosphorylase family.
Protein: RL10_RHOPT
Sequence: MERAAKKEAVESLNGLFQTTSVAIVAHYSGLTVAQMQKLRQQMKQAGASVKVSKNRLAKIALEGTDVAAIGPLLKGPTVIATSSDPVAAPKVAVEFAKANEKFVILGGSMGTTVLNVDGVKALASLPSLDELRAKLVGLVQAPATKIAQVTTAPAAKLARVVQAYASKSEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: GMH2_SCHPO
Sequence: MALMLSRIPRRFFFLFLTVGLIAGAFLYSLIYFVDVDLVSKVNQLYDQQIAPMLSDAIGTPSVNHSFELAPLDSHLVATSTTFHEASYESEPQQNPASQNIVLLLVSDGHTSYNNGANTFEEAIQNRVDYSTKQNYNFEYVNVTGLPIPAVWSKMPAVLQTMKKYPKAEWIWLLDQDAIITNTHLSLQDSFLKPENLQKTLITNTILTKRPINANGDLRYTPSNYSLKDIENLMVIISQDHNGLNAGSILFRNSPATALFLDIWTDPVVAECAKANNEQDMLGYLISKHSQLASLVGLIPQRKINAFHEGPENMEWQKGDLVIHFAGCWVENRCDELWQKFYALID
What are the official names of this protein?
Probable alpha-1,2-galactosyltransferase gmh2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 34 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: ANKR1_MOUSE
Sequence: MMVLRVEELVTGKKNSNGAAGEFLPGEFRNGEYEAAVALEKQEDLKTLPANSVKQGEEQRKSEKLREAELKKKKLEQRSKLENLEDLEIIVQLKKRKKYKKTKVPVVKEPEPEIMTEPVDVPRFLKAALENKLPVVEKFLSDKNSPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWACRGGNADVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLMTFGADLKVKNCAGKTPMDLVLHWQSGTKAIFDSLKENAYKNSRIATF
What is the function of this protein?
May play an important role in endothelial cell activation.  May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.
What are the official names of this protein?
Ankyrin repeat domain-containing protein 1, Cardiac ankyrin repeat protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNMA_THEM4
Sequence: MKKKGYAVTAYHLKTVPDSLYLTKQIKHKVCCSPSDTFDAKKVAQKFGVELKIIHVENVFRETIIKYFINEYKRGRTPNPCFFCNDWIKFGVLLERIIQDGNDYVASGHYALLRDGKLYKAKNKEKDQSYFLASIKREKLGYLVFPNGEYNKDEIRNIAKDLNIHIHSKEDSQDLCFIPDNNIYGFLKENGVGFKEGLIIDTKGNILGTHKGLSNYTIGQRKIGIAVRERMYVLRKDFEKNLLVVGKKGEVFNNKFTVSKLNFLQDVYKKIEGYVKVRKKFKEVKCRVYVDNDNLYVETREPIFAITPGQIAVIYDEDGAVIVSGVIEKEGWNGFESFN
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SF3A3_MOUSE
Sequence: METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRYMEVSGNLRDLYDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPNEICVPMSVEFEELLKARENPSEEAQNLVEFTDEEGYGRYLDLHDCYLKYINLKASEKLDYITYLSIFDQLFDIPKERKNAEYKRYLEMLLEYLQDYTDRVKPLQDQNELFGKIQTDFEKKWDNGTFPGWPKETSSALTHAGAHLDLSAFSSWEELASLGLDRLKSALLALGLKCGGTLEERAQRLFSTKGKSLESLDTSLFAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRQLTHENVQRKQARTGEEREEEEEEQISESESEDEENEIIYNPKNLPLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPKAFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKLKLQKASERWQPDTEEEYEDSSGNVVNKKTYEDLKRQGLL
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex.  Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.
What are the official names of this protein?
Splicing factor 3A subunit 3, SF3a60, Spliceosome-associated protein 61, SAP 61.
What is the protein family that this protein belongs to?
Belongs to the SF3A3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NSI1_YEAST
Sequence: MDSVSNLKSTNFQNNNDPKESVEEAVLRYVGVDLKNHIKKTKKKLKKQKKRKHGSKMSHEDEDTDMDWYLKTSGSKDLRKVDDIEPNSVAVAAVAAAYNSSMREKDKRSCHKKSSNSRSERKKHRKRKSSKERKAKIKMVLDPQLTTLDDGITTTAFLPDDLIAETAFDKYVDTEKAYLAKHPSKSLEVNEDDKENNFNNNSSTLVRIYTDLEGIPNDGSYIKRTPKIPEKDVKSDDLILAPEENNGDTALLRSDIVKASVIDGAITKSIGKKFTPSEENALDQFIEEYMKIRGLDRRQMCERIWSTDGVIRDGFWANISKVLPYRTRSSIYKHIRRKYHIFEQRGKWTPEEDQELARLCLEKEGHWTEVGKLLGRMPEDCRDRWRNYMKCGSKRGSKRWSKEEEELLTTVVNEMIEEAHQYQRMKALEAANKNDRYNQMYSRGPKGKRISDNPTFKDMINWTVVSERMSGTRSRIQCRYKWNKLVTDEAARSMLSIPVSERKWLLERLKQLPKTSYSNIDWNSIATYKPGYPRTGLELRLCYEQMREKIHDFKGRSTAEIIDSLLEQIN
What is the function of this protein?
DNA-binding protein that recognizes sequence-specific replication termini (Ter sites) within rDNA (PubMed:14576157).  Binds to rDNA terminator elements and mediates efficient RNA polymerase I transcription termination (PubMed:22805593).  Required for rDNA silencing at the non-transcribed spacer 1 (NTS1).  Promotes the association of SIR2 with NTS1 and contributes to maintenance of rDNA stability (PubMed:22362748).
What are the official names of this protein?
RNA polymerase I termination factor, NTS1 silencing protein 1.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ASR_YERPB
Sequence: MKKVLALMVAATLGLSSVAFAADTTATATPAATSTTATVAAQTKATQHQKHKVTKKTTEQKAQAAKKHEKKASVQKAPVQKAQAAKKHVKKASVQKAPVQKAQAAKKHHKTAKKPVAAPAA
What is the function of this protein?
Required for growth and/or survival at acidic conditions.
What are the official names of this protein?
Acid shock protein.
What is the protein family that this protein belongs to?
Belongs to the Asr family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MRJP1_APIME
Sequence: MTRLFMLVCLGIVCQGTTGNILRGESLNKSLPILHEWKFFDYDFGSDERRQDAILSGEYDYKNNYPSDIDQWHDKIFVTMLRYNGVPSSLNVISKKVGDGGPLLQPYPDWSFAKYDDCSGIVSASKLAIDKCDRLWVLDSGLVNNTQPMCSPKLLTFDLTTSQLLKQVEIPHDVAVNATTGKGRLSSLAVQSLDCNTNSDTMVYIADEKGEGLIVYHNSDDSFHRLTSNTFDYDPKFTKMTIDGESYTAQDGISGMALSPMTNNLYYSPVASTSLYYVNTEQFRTSDYQQNDIHYEGVQNILDTQSSAKVVSKSGVLFFGLVGDSALGCWNEHRTLERHNIRTVAQSDETLQMIASMKIKEALPHVPIFDRYINREYILVLSNKMQKMVNNDFNFDDVNFRIMNANVNELILNTRCENPDNDRTPFKISIHL
What is the function of this protein?
Lacks antibacterial and antifungal activity.  Lacks cytolytic activity and does not induce rat peritoneal mast cell degranulation.
What are the official names of this protein?
Major royal jelly protein 1, MRJP-1, MRJP1, 56-kDa protein 4, p56kP-4, Apalbumin 1, Apisin subunit MRJP1, Bee-milk protein, Royalactin.
What is the protein family that this protein belongs to?
Belongs to the major royal jelly protein family.
What are the subcellular locations of this protein?
Secreted. Note=Royal jelly.
Protein: RS4_PSELT
Sequence: MARYTGPICRLCRREGMKLYLKGERCFTEHCAFDKRPYAPGDHGRQRGKLSQYGTQLRAKQVMRVIYGIPERQFEHYFEKALGMSGDTRENLVRLVESRVDNIVYRLGFAISRRQARQLVTHGHFSVNGVKIDIPSYKLRPGDIVEVREKSRSLAAIKHAVESSKDRTQVPWVEVDFDSYRGTFLRLPNLEEVTDLPVDVQAIVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: MAN1_SOLLC
Sequence: MSYARRSCICGLFLLFLALVCEANSGFIGVKDSHFELNGSPFLFNGFNSYWLMHVAADPTERYKVTEVLKDASVAGLSVCRTWAFSDGGDRALQISPGIYDERVFQGLDFVIAEAKKYGIRLILSFVNQWNDFGGKAQYVWWARNAGAQISNDDEFYTHPMLKKYLKNHIEKVVTRLNSITKVAYKDDPTIMAWELMNEPRDQADYSGKTVNGWVQEMASFVKSLDNKHLLEVGMEGFYGDSIPERKSVNPGYQVGTDFISNHLINEIDFATIHAYTDQWVSGQSDDAQLVWMEKWITSHWEDARNILKKPLVLAEFGKSSRGQGSRDIFMSSVYRNVYNLAKEGGTMAGSLVWQLMAHGMENYDDGYCIVLGQTPSTTQIISDQAHVMTALARSLN
What are the official names of this protein?
Mannan endo-1,4-beta-mannosidase 1, Beta-mannanase 1, Endo-beta-1,4-mannanase 1, LeMAN1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: DYLT1_BOVIN
Sequence: MEDYQAAEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKPFKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTMYCIVSAFGLSI
What is the function of this protein?
Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity.  The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer.  May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange.  Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2.  Involved in the regulation of mitotic spindle orientation.  Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B.  Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (By similarity).
What are the official names of this protein?
Dynein light chain Tctex-type 1, T-complex testis-specific protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain Tctex-type family.