PharMolix/UniProtQA huggingface dataset:
Protein: TIGAR_MOUSE
Sequence: MPRFALTVIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAAAGQFLSNVQFTHAFSSDLTRTKQTIHGILEKSRFCKDMAVKYDSRLRERMYGVAEGKPLSELRAMAKAAGEECPMFTPPGGETVEQVKMRGKDFFDFICQLILGKAGQRESVLPGAPGSGLESSLAEVFPVGKHGSLGANPKGGTLGLAASILVVSHGAYMRSLFGYFLSDLRCSLPGARDKLELSSITPNTGISVFIIDCEEARQPSIQCVCMNLQEHLNGVTEKQH
What is the function of this protein?
Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (By similarity).  Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:23726973).  Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:23726973).  Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (By similarity).  In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3 (PubMed:22044588).  Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (PubMed:22044588).  Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973).  Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (PubMed:24872551).  Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner.  Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (By similarity).  Involved in intestinal tumor progression (PubMed:23726973).
What are the official names of this protein?
Fructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, TP53-induced glycolysis regulatory phosphatase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner. Colocalizes with HK2 in the mitochondria during hypoxia. Translocated to the nucleus during hypoxia and/or genome stress-induced DNA damage responses in cancer cells (By similarity). Translocation to the mitochondria is enhanced in ischemic cortex after reperfusion and/or during oxygen and glucose deprivation (OGD)/reoxygenation insult in primary neurons (PubMed:24872551).
Protein: PYRB_DESDA
Sequence: MNTDNRYHWPHKDLLDVTQLSRADTLHLLDLAASFQEINSRPVKKVPTLKGKTVVLFFVENSTRTKTSFDVAGKRLSADTFALGKSGSSLNKGESLKDTALTLQAMSPDVIVMRHSSSGAARYVADLLPCGVVNGGDGWHAHPTQALLDCFSLREAWANSFEGRTLLILGDIAHSRVARSNIHLLTSLGVRIRVCAPRTLLPAGVDHWPVEVYTDLRQAVRDVDAVMCLRLQLERQQAGLLPDLAEYSRRFCLGLEHMALARPGAGVLHPGPMNRGLEISDDMADAPASLVLDQVAAGVATRMAVLYLLATRNDGGRA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: SYQ_ERWT9
Sequence: MSEAEARPTNFIRQIIDEDLENGKHSMVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDLEFVESIKRDVQWLGFQWSGEVRYSSDYFEQLHNYAVELIGKGLAYVDELSPEQIREYRGSLTSAGKNSPYRDRSVAENLELFAKMRNGEFAEGTACLRAKIDMASNFIVLRDPVIYRIKFADHHQTGNRWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYAIMSKRKLNLLVTEKVVEGWDDPRMLTVSGLRRRGYSAGSIREFCRRIGVTKQDNIVEMAALESCIRDDLNENAPRAMAVLDAVKVVIENLPAHHEQTICMPNHPNRPEMGTRQVPFSREIYIDRADFREEANKHYKRLVLGKEVRLRNAYVIKAERIAKDEEGNITCLFCSCDIDTLSKDPADGRKVKGVIHWVSAEHALLAEFRLYDRLFSVPNPAAAEDFLTTINPESLVIRQGFVEPGMQQALASAPYQFEREGYFCADSVYSTSNKLVFNRTVGLRDTWAKNGE
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_HYDCU
Sequence: MVKTRFAPSPTGYLHIGGVRTALFSWLYAKQKKGEFTLRIEDTDLERSTQESVQAILDGMAWLGLDYDKGPIYQTERFDRYKAVIQDLMDRGLAYYCYASPEELDEMREAQKARGDKPRYDGRYRDFDGTPPEGVKPVIRFKNPEDGEVVIDDLVKGRIVVANKELDDLVIARSDGTPTYNLTVVVDDWDMEMTHVIRGDDHINNTPRQINLYKALGAEPPKFAHIPMVLGEDGSRLSKRHGAVSVLQYKEDGFLPEALLNYLVRLGWSYKDQEIFTIQEMIDLFQLESVNASPSTFNLEKLLWINQQHIQMTDIDNLVKNLKPFMDQKGIDTEKGPELSHVANLLRERAKTLIEMADSAAYFYQDFTEFEAGAAKKHLRPVAEEPLRLVQKKFAELTEWKADKIHEAVHQAAEDLEIGMGKVGMPLRVAITGGGQSPSIDATAELIGQQKCVARIDLALQAIEARKANS
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URED_HAEIE
Sequence: MNSKLSLSTKLSSSGKTQLAEYFAKPPFKVITLPSYDDAWANGLNAMQMSSSPGVLAGDVLEIDISLAKLTALSLNTQAFTRVQAMNEGDSAMQTTHILLAENSRLFYLPHPLVLHKDSVFKQQTHIEMGEQSELIYGEIVAIGRVLNDERFAFRQFSSHLKIYTLQDDGKKRPLVSDCIQWLPSKMNLTALSQMENYSHQGSLTYLNLAKNNAEIKQQVQALQQQSAEEKDLLIGISQLNEYGLMVRVLGCRAEQIQKLFEKIGRLLKSV
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_SALSV
Sequence: MSQLTHINAAGEAHMVDVSAKAETVREARAEAFVTMRSETLAMIVDGKHHKGDVFATARIAGIQAAKRTWELIPLCHPLLLSKVEIQLQAEPEHNRVRIESLCRLTGKTGVEMEALTAASVAALTIYDMCKAVQKDMVIGPVRLLAKSGGKSGDFKVDAHD
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: HISZ_CHESB
Sequence: MTSRYPSFAAEILDLFAEREAVLTDIAIIQPADPFLDMAGEDLRRRIFLTESETGETLCLRPEFTIPVCLDHIEKRASTPRRYAYLGEVFRQHREGSPEFFQAGVEDLGAKDRPAADARSLADARAILSCVLPNTGFHVTLGDQAVFEAVLSALGLPRGWQKRLARAFGSPAMLEAAIAEFTSPQGTANLPREVASLVAQGNEQRLTHHIEEAMQAAGHSPTAGREPDEIARRLLEKAALRSVRLSDAALNALKSFLAIKVPLEQAGERLTAFADEAGIFLDEALADFSARAERIGDHALPLDEIRYDAGFGRPLDYYTGFIFEIGVEGLRQPLVGGGRYDRLLTLLGAEEPIPGVGFSMWLDRIATVRGEKP
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_SHEB5
Sequence: MLDPKFLRNELEVTAERLATRGFILDIAHLTQLEEKRKSLQVATEELQASRNAISKSIGQAKARGEDVDAIMAQVGDLGSQLDAKKIELAAVLEEVNAIAMSMPNLPDESAPIGADETENVEVRRWGTPRTFDFPIKDHIDLGEGLNGLDFKNAVKITGSRFIVMKGQVARLNRAIGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPLTNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPEDSMAALEALTGHAETVLQRLGLPYRTVILCTGDMGFGSSKTYDIEVWLPAQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAILENYQNADGSITIPEVLRPYMGGLTKIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_ECOHS
Sequence: MRHPLVMGNWKLNGSRHMVHELVSNLRKELAGVAGCAVAIAPPEMYIDMAKREAEGSHIMLGAQNVDLNLSGAFTGETSAAMLKDIGAQYIIIGHSERRTYHKESDELIAKKFAVLKEQGLTPVLCIGETEAENEAGKTEEVCARQIDAVLKTQGAAAFEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRDHIAKVDANIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGASLKADAFAVIVKAAEAAKQA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_SHEB2
Sequence: MPELPEVEVTRQGIAPFLVEQTVVDLVIRNGSLRWPVPDIAKQIIGQVIRQVRRRAKYLLIDTDAGTSIVHLGMSGSLRILPHDTPVEKHDHIDLVLANGRILRFNDPRRFGAWLWCELPEEAHPLLAKLGPEPLTNAFNVTQLAAALAGKKKAIKLCLMDNHIVVGVGNIYANEALFAAGIHPEAEAGKIDIERLTVLVAEVKQILAHAIKQGGTTLKDFTNADGKPGYFAQKLHVYSRGGETCTSCGNLLSEIRLGQRTTVFCGICQTR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RDH54_YEAS6
Sequence: MQIPKYENKPFKPPRRVGSNKYTQLKPTATAVTTAPISKAKVTVNLKRSISAGPTLNLAKKPNNLSSNENTRYFTIMYRKPTTKKHKTWSGDGYATLKASSDKLCFYNEAGKFFGSSMLPSDSDSLFETLFKAGSNEVQLDYELKENAEIRSAKEALSQNMGNPNPPTTSTTETVPSTKNDGGKYQMPLSQLFSLNTVKRFKSVTKQTNEHMTTVPKTSQNSKAKKYYPVFDVNKIDNPIVMNKNAAAEVDVIVDPLLGKFLRPHQREGVKFMYDCLMGLARPTIENPDIDCTTKSLVLENDSDISGCLLADDMGLGKTLMSITLIWTLIRQTPFASKVSCSQSGIPLTGLCKKILVVCPVTLIGNWKREFGKWLNLSRIGVLTLSSRNSPDMDKMAVRNFLKVQRIYQVLIIGYEKLLSVSEELEKNKHLIDMLVCDEGHRLKNGASKILNTLKSLDIRRKLLLTGTPIQNDLNEFFTIIDFINPGILGSFASFKRRFIIPITRARDTANRYNEELLEKGEERSKEMIEITKRFILRRTNAILEKYLPPKTDIILFCKPYSQQILAFKDILQGARLDFGQLTFSSSLGLITLLKKVCNSPGLVGSDPYYKSHIKDTQSQDSYSRSLNSGKLRVLMTLLEGIRKGTKEKVVVVSNYTQTLDIIENLMNMAGMSHCRLDGSIPAKQRDSIVTSFNRNPAIFGFLLSAKSGGVGLNLVGASRLILFDNDWNPSVDLQAMSRIHRDGQKKPCFIYRLVTTGCIDEKILQRQLMKNSLSQKFLGDSEMRNKESSNDDLFNKEDLKDLFSVHTDTKSNTHDLICSCDGLGEEIEYPETNQQQNTVELRKRSTTTWTSALDLQKKMNEAATNDDAKKSQYIRQCLVHYKHIDPARQDELFDEVITDSFTDLKDSITFAFVKPGEICLREQ
What is the function of this protein?
Involved in the recombinational repair of double-strand breaks (DSB) in DNA during mitosis and meiosis.  Has DNA dependent ATPase activity.  Promotes D-loop (displacement loop) formation with RAD51 recombinase.  Modifies the topology of double-stranded DNA during the D-loop reaction to facilitate the invasion of the homologous duplex molecule by the initiating single-stranded DNA substrate.  Required for adaptation from G2/M checkpoint arrest induced by a double strand break, by participating in monitoring the extent of single-stranded DNA produced by resection of DNA ends.  This role is distinct from its roles in recombination.  Promotes colocalization of RAD51 and DMC1 during meiotic recombination.  Involved in crossover interference (By similarity).
What are the official names of this protein?
DNA repair and recombination protein RDH54, RAD homolog 54, Recombination factor TID1, Two hybrid interaction with DMC1 protein 1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRH_BURL3
Sequence: MSNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATMMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKATKVDGVYSADPKKDPSATRYTTITFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXB_SHEFN
Sequence: MKIIADENMPYVDALFGYLGKIEYVNGRTLTPKQVEDADVLLVRSVTKVNAELIKDAHKLKFVGSATIGTDHVDVDYLSLRNIYFTNAPGCNATAVGEYAFIAMLELAQRFGESLAGKVVGIVGAGNTGTAAAKCMQAYGLKVLLCDPIKALQGDTREFVSLDTIIEQADIISLHVPITKDGEHKTWYLFDEARLNKLKPNTWLLNCCRGEVIDNRALIKFKQQRDDVKLVLDVWEGEPNPMAELVALAEFATPHIAGYSLEGKARGTFMLYQKWCELLDFPVKKSLESLLPTFQFNQIVSQGDLTESQLLKLSRLVYDLRDDDVNFRGCFSTATGFDLMRKKHTYRREYSAISLTQSVDYLSDGKIDPSMLSALGFN
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y206_LISMO
Sequence: MYIKGRLIFFFVVLVIALCSVLILLIIKISVWKDEPFHLSDAKEIECLGSCEIKNTNQKIHFFSIKENLFEEKGDIAGILNEDEQKVADKSIFIVILDDEKGIANEE
What are the official names of this protein?
Uncharacterized protein Lmo0206.
Protein: ZNFX1_MOUSE
Sequence: MEDRRPHLEARPRNPPANHRGPMDGELPPRARNQTNNPAATNHAGRHLRASNHPAPFRQREERFRAMGRNPHQGRRNQEGHTSDEARDQRQSQNDTRRRNDDQEGRSHRPPWSSDTFQQWHTPPQKPGEQPQQTKRLGYKFLESLLQKEPSEVAITLATSLGLKELLSHSSMKPSFLQLICQVLRKACSSRIDRQSILHVLGILNNSKFLRVCLPAYVVGMITEPSPDIRNQYPEHISNIISLLQDLVSVFPASSMQETSMLISLLPTSLNALRASGVDIEEETEKNLEKVQAIIKYLQEKRRQGSLRVDTYTLVQAEAEGEVESYRAMPIYPTYNEVHLDEKPFLRPNIISGKYESTAVYLDTHFRLLREDFVRPLREGILKLLQSFEDQCLRKRKFDDIRIYFDARIITPMCSASGIVYKVQFDTKPLKLVRWQNSKRLLYGSLVCMSKDNFETFLFATVSNREHEDLCQGIVQLCFNEQSQQLLADVQPSDSFLMVETTAYFEAYRHVLEGLQEVQEEDVPFQRNIVQCDSYVRNPRYLLMGGRYDFTPLMENPSAMRKSLRGAEALRHPRINVFDFGQWPSKEALKLDDSQMEALQFALTKELAIIQGPPGTGKTYVGLKIVQALLTNKSVWQINTQTFPILVVCYTNHALDQFLEGIYGCQKTSIVRVGGRSNSEILKQFTLRELRNKREFRRTLPMHLRRAYMSIVTEMKESEQKLQEGAQTLECTMHGVLREQHLEKYISAQHWESLMSGPVQDADWVCVQPSKHSMILEWLGLGVGSFTQSASPAGPENTAQAEGEEEEEGEEEGSLIEIAEEADLIQADRVIEEEEVVRPRRRKKEENGTDQELAKMLLAMRLDQEVPGTTAGPEQATEEWETQRGQKKKMKRRVKVELRKLNTMTKAEANGIQDVWQLDLSSRWQLYRLWLQMYQADTRRRILSYERQYRTWAERMAELRLQEDLHILKDAEVVGMTTTGAAKYRQILQQVEPRIVIVEEAAEVLEAHTIATLSKACQHLILIGDHQQLRPSANVYDLAKNFNLEVSLFERLVKVNIPFVRLNYQHRMRPEIARLLTPHIYQDLENHPSVLKYEQIKGVSSNLFFVEHNFPEQEIQEGKSHQNQHEAHFVVELCQYLLCQEYLPSQITILTTYTGQLFCLRKLMPVKTFAGIKVHVVDKYQGEENDIILLSLVRSNQEGKVGFLQIPNRICVALSRAKKGMYCIGNMQMLAKVPLWSRIIHTLRENNQIGPSLRLCCQNHPETHTLVSKASDFQKVPEGGCSRPCEFRLACGHVCTRACHPYDSSHKEFQCMKPCQKVLCQDGHRCPNVCFQECQPCQVKVPKIILKCGHKQMVPCSMSESEFCCQEPCSKILRCGHRCSHLCGEDCVRLCSERVTVELKCGHSQLVKCGNVEDIKYGLPVKCTTKCDTTLDCGHPCPGSCHSCFEGRFHERCQQPCKRLLICSHKCQEPCTGECPPCQRTCQNRCVHSQCKKKCGELCSPCVEPCVWRCQHYQCTKLCSEPCNRPPCYVPCTKLLACGHPCIGLCGEPCPKKCRVCQPDEVTQIFFGFEDEPDARFVQLEDCSHIFEVQALDRFMNEQKDDEVAIKLKVCPICQVPIRKNLRYGTSIKQRLEEIEIVKEKIQGSAGEISTSQEQLKALLKSKTLFHQLRPEEFLILQEKLAQKNLSVKDLGLVENSIRFYDHLANLEGSLEKVHCGEQQSVRTRLEQVHEWLAKKRLSFSSQELSDLQSEIQRLTYLVNLLMRCKMAEKVKGSIAEEVSSIRNILEKTSKFTQEDEQLVQKKMDALKTTLPCSGLGISDEERVQIVTAMGVPRGHWFKCPNGHIYVITECGGAMQRSTCPECQEVIGGENHTLERSNHLASEMDGAQHPAWSNTANNFMNFEEIHRMM
What is the function of this protein?
RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses (PubMed:31685995).  Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (PubMed:31685995).  Also required for immunity against some bacteria, such as mycobacteria (By similarity).
What are the official names of this protein?
NFX1-type zinc finger-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the ZNFX1 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane. Cytoplasm, Stress granule.
Protein: MATK_LEMMN
Sequence: MEDFKGYLQKGGFKQQHLLYPLLFQEYIYALAHDQGLNVNASTFNEPPEISGYDKKYSSLLVKRLINRLYQQNTFIHSVNNSKDNRFVGHNKNFYYQMISEAFAIVVEIPFSRRLVSSLKEKKEIPKYQNLRSIHSLFSFLEDKFSHLNYVSDILVPYPVHLEILVQILQCWIQDVPTLHLLRLLFQDYHNGNNRITPNKSTYGFSKDNPRLYRFLYNSYVVEYEAIFVFLRKSSSYLRSTSFGPLLERTHFYRKMKHIGVTCCNDFQKTLWLFKDALMHYVRYQGKSIMASKGNHLLMKKWKSYFVNLWQCHFHFWSQPSRIHINQFPHFSFYFLGYLSSVPINPSSAKSQMLENSFLIDTVTPKFETMISIIPMIGSLAKAKFCNLSGNPLSKPVWAELSDSDIIDRFGRIYRNLSHYYSGSSKKQTLYRIKYILRLSCARTLARKHKSTVRAFLQRLGSEFFEEFFIEEDKILSLILPTTSYSLQQLSRESVWFLDIIRINDLVNHLDL
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TSAD_CUPNH
Sequence: MLVLGIESSCDETGLALYDTGAGLLAHALHSQIAMHRDYGGVVPELASRDHIRRVLPLLEQVLADAGRTRQDIDAIAFTQGPGLAGALLVGASVANALGFALNVPMVGVHHLEGHLLSPLLTREPPPFPFVALLVSGGHTQLMEVRGIGDYTLLGETLDDAAGEAFDKTAKLLGLGYPGGPEVSRLAEFGIPGAFALPRPMLHSGNLDFSFAGLKTAVLTQTRKLANTCEQDRANLARAFVDAIVDVLAAKSMAALKQTGHKRLVVAGGVGANRQLRERLDQMGKQRKIDVYYPDLAFCTDNGAMIAFAGAMRLQAAPELARHEYGYGVTPRWDLADIRLPSAA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_XANOM
Sequence: MSARKYFGTDGIRGRVGQGVISADFVLRLGNALGRVLTQIRGKRPLVLIGKDTRISGYMFEAALEAGLVAAGADVQLIGPMPTPAIAFLTSTLRADAGVVISASHNPHYDNGIKFFSAEGEKLDDATEAAIEAALDAPFHTVESERLGKAIRTRDAIGRYIEFCKASVARGFTLKWLKMVLDCAHGATYHIAPMLFRELGAEVVVIGAAPDGLNINAGVGSTHIDNLAAKVREYGAHLGIAFDGDGDRVLMADDQGNPVDGDDLLYVLARSWQASGRLTGTVVGTLMTNYGLEQALAALNIPFQRAKVGDRYVHQALVEGGGTLGGETSGHLLCLDRATTGDGIVSALQVLEALGRDGHSLRKALSSLSKVPQKTVNVRLDGGAAKAIVEAANVQQALQQAQAAVQGRGRAFLRPSGTEPVVRVTVEADDARLMQDTLDRLSGAVRDAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: ACYP2_PIG
Sequence: MSTARPLKSVDYEVFGRVQGVCFRMYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEEKVNSMKSWLSKIGSPSSRIDRTNFSNEKTISKLEYSNFSIRY
What is the function of this protein?
Its physiological role is not yet clear.
What are the official names of this protein?
Acylphosphatase-2, Acylphosphatase, muscle type isozyme, Acylphosphate phosphohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: RPPH_BURTA
Sequence: MLDREGFRPNVGIILLNAHNEVFWGKRLREHSWQFPQGGIKYGETPMQAMYRELHEETGLLPEHVKIIGRTRDWLRYEVPDKFIKREVRGHYRGQKQIWFLLRMVGRDCDICLRATDHPEFDAWRWNEYWVPLDAVIEFKRDVYQLALTELSRFLRRPAQRTDKSRGPRAPRYPRVSNGHAASETPAVIDASAVCSEVEPGASTLDEIPPRLILRD
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: MURA_RHOPS
Sequence: MDRIRIIGGNKLHGTIPISGAKNAALPLMIAAMLSDETLILDNVPRLADVALLQRILGNHGVDIMAVGKRPGDHEYQGQTLHISAKNIIDTTAPYDLVSKMRASFWVIAPLLARMHEAKVSLPGGCAIGTRPVDLLIMALEKLGAELSIDAGYVVAKAPGGLKGATIEFPKVTVSGTHVALMAAALAKGTTIIANAACEPEITDVADCLNKMGAKITGAGTPRIMIEGVSKLHGARHTVLPDRIETGTYAMAVAMTGGEVQLSGARPELLQSALDVLTQAGVTITVNNDGIKVARNGAGISPVTVTTAPFPGFPTDLQAQLMALMTRAKGASHITETIFENRFMHVQELARFGARIQLDGETATIDGVAKLRGAPVMATDLRASVSLVIAALAAEGETMVNRIYHLDRGFERLEEKLSACGATIERISG
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRT16_YEAST
Sequence: MSMKSHLELFKQKKSTAYILLTVLFGIGWATLDLPVMVAMNIRPSISMRPIKPYISWLDSLLKPLPFNSAFGTNSTAHVDLREFLLFIGLNTSPCVSETIAIFLVCCFDRSIFIATEYLFLILLPLRGLCHQFCEQKYVETI
What is the function of this protein?
Identified in a screen for mutants with decreased levels of rDNA transcription.
What are the official names of this protein?
Putative regulator of rDNA transcription protein 16.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MENC_SALEP
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLRDGEREGWGEISPLPGFSQETWEEAQTALLTWVNDWLQGSEGLPEMPSVAFGASCALAELTGVLPEAADYRAAPLCTGDPDDLVLRLADMPGEKIAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKAQQFAKYVNPDYRARIAFLEEPCKTRDDSRAFARETGIAIAWDESLREADFTFEAEEGVRAVVIKPTLTGSLDKVREQVAAAHALGLTAVISSSIESSLGLTQLARIAAWLTPGTLPGLDTLHLMQAQQVRPWPGSALPCLKRDELERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: ATPA_CHLVU
Sequence: MVKIRPDEISSIIKQQIEQYQQEVKAVNVGTVFQVGDGIARIYGLDKVMAGELVEFEDGTVGIALNLEAKNVGAVLMGEGTRVQEGSSVRATGKIAQIPVGDGYLGRVVNSLARPIDGKGEIATKENRLIESPAPGIISRRSVHEPLQTGIVAIDAMIPIGRGQRELIIGDRQTGKTAIAVDTILNQKGKDVVCVYVAIGQKASSIAQVVNTLQERGAMDYTIIVAATADSPATLQYLSPYTGAALAEYFMYTGRHTLVIYDDLTKQAQAYREMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDKLGSGSMTALPVVETQEGDVSAYIPTNVISITDGQIFLSADIFNAGIRPAINVGISVSRVGSAAQPKAMKQVAGKLKLELAQFAELEAFSQFASDLDQATQNQLARGQRLRELLKQSQSSPLSLEDQVASIYAGTNGYLDVLPADRVRAFLVGLRQYLATNKAKYGEILRSTNALTDEAQTLLKEALKEYTEEFLASAK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.