PharMolix/UniProtQA huggingface dataset:
Protein: GCST_HALS3
Sequence: MGLRTSPLHGRHEDRGASFTEFGGWNMPVDFDGIQAEHAAVREAAGIFDVSHMGEIEVSGPDAERLMQRLTTNDVSRLDPGDAQYAAITDDDGIMIDDTVVYRTPADWPGAFLFVPNAGHDAAAFDRWTDHRDAHDLDASVDNVTTDYGMVAVQGPDAPDLVAARAGDGVHDLGRFEAATVGVAGVECLVANTGYTGEAGVEIVFPADGAGAVWDAIANDCQPCGLGARDTLRMEHGFLLSGQDFDPEENPRTPFEAGIGFAVAPESGFVGRDALADTDSPEQQFVGLTLDERGVPRHGYAVTTPAGDEIGTVTSGTMSPTLGEPIGLGYVDSAHAADGTTVAVRIRGTDKQATITTPPFLDQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Probable aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: MP64_MYCTU
Sequence: MRIKIFMLVTAVVLLCCSGVATAAPKTYCEELKGTDTGQACQIQMSDPAYNINISLPSYYPDQKSLENYIAQTRDKFLSAATSSTPREAPYELNITSATYQSAIPPRGTQAVVLKVYQNAGGTHPTTTYKAFDWDQAYRKPITYDTLWQADTDPLPVVFPIVQGELSKQTGQQVSIAPNAGLDPVNYQNFAVTNDGVIFFFNPGELLPEAAGPTQVLVPRSAIDSMLA
What are the official names of this protein?
Immunogenic protein MPT64, Antigen MPT64.
What is the protein family that this protein belongs to?
Belongs to the RsiV family.
What are the subcellular locations of this protein?
Secreted.
Protein: KDPA_ECOSE
Sequence: MAAQGFLLIATFLLVLMVLARPLGSGLARLINDIPLPGTTGVERVLFRALGVSDREMNWKQYLCAILGLNMLGLAVLFFMLLGQHYLPLNPQQLPGLSWDLALNTAVSFVTNTNWQSYSGETTLSYFSQMAGLTVQNFLSAASGIAVIFALIRAFTRQSMSTLGNAWVDLLRITLWVLVPVALLIALFFIQQGALQNFQPYQAVNTVEGAQQLLPMGPVASQEAIKMLGTNGGGFFNANSSHPFENPTALTNFVQMLAIFLIPTALCFAFGEVTGDRRQGRMLLWAMSVIFVICVGVVMWAEVQGNPHLLALGADSSINMEGKESRFGVLVSSLFAVVTTAASCGAVIAMHDSFTALGGMVPMWLMQIGEVVFGGVGSGLYGMMLFVLLAVFIAGLMIGRTPEYLGKKIDVREMKLTALAILVTPTLVLMGAALAMMTDAGRSAMLNPGPHGFSEVLYAVSSAANNNGSAFAGLSANSPFWNCLLAFCMFVGRFGVIIPVMAIAGSLVSKKSQPASSGTLPTHGPLFVGLLIGTVLLVGALTFIPALALGPVAEYLS
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1372_THEGJ
Sequence: MIINETKGRVWHGHVELADTFIKRFRGLMLVSNVNHALIFVLPIENRLNASIHMFFMLSDIDVIWLDSMRRVVDFKTARRWRIYTPKESARYVIEGPVGLIRTLDVEEGDLISWDVTEKKEKSVPVKVSFPGKISFENERNTVVFSKDIIELP
What are the official names of this protein?
UPF0127 protein TGAM_1372.
What is the protein family that this protein belongs to?
Belongs to the UPF0127 family.
Protein: TARA_MOUSE
Sequence: MSMEQDTRALLPTQGTAWATASAPVARLQGPQGDSHQACSQEPHSPSSAEAPYCDLPRCPPALQNPLRTTTCVGQSVHSLGLGLGQEPQRVWSPTTALPAEGPAAAPKNRHQDSEGIPYLEGLARSSCTDDNDNKDEDEDPNSNTSSSQDSNTPHDTSNSSSVDWDTTERPGVVPSRNRLTEMIPRRPQEGLRADSARKATRSPARGDTAGQRKENSGSGGQSAGQHWAKLRSESGYFSLERQRSGQTQASSGTPPSGPRGTTQASSAQRDVFQAAPAQEAPQTSSLPRNTQRDTQRSTPRTSSPSRVSQRDTPRVMSTQRKNTPLSSPLRATPETLKISAPEDGTHVTPSPCVQDSSLNRTSQRDSSRTPCIQWDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCAQRDNPRAASPNRSTQRDSPRTPCAQRDNPRASSPNRTAQRDNPRTPCAQRDNPRTSCTSQNTPRTPSTQADKTTASCSKWEHLRSACTQRDNPRTFSQGCTQKDNPGPPSPRRATQGSNSRNPSPHRTNKDIPWASFPLRPTQSDSPRTSSPSRTKQNQVPWASISLRPTQGDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSASRTSSPLHAAPRGAPQTSLESSQPPCTVCIGHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDTSDADNESPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESLVPSTDSMHEPPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPQVCIGHRDAPRASSPPRHPPSDIGLLAPSPPPGSSGSRGSAPPGETRHNLEREEYTMLADLPPPRRLAQRGPEPQAQGSNEGRTRSPGRAEVERLFGQERRKSEAPGAFQTRDEGRSQRPSQAQSQLRRQSSPAPSRQVTKPSAKQAEPTRQSRTGPPHPKSPDKRPEGDRQLQRTSPPARTPARPPERKAQIERHLESGHTGPRQSLGGWQSQERLSGPQSPNRHPEKSWGSQKEGPSLGGWPELEGPSLEGIWRGPPQEHREQWGHSEAWEEPPSNGIQGAPPRGQGRLQELSRPHQPTPSSENSWAGPAECSCALQPEASTAVGWRAEGTSPHQRSAERPPDLDWRDLLGLLRAPEDGAWTRLPRLDWEGLLELLQARLPQKDPARHWHDPAKASGPEQGSSGTEDTLKTEPQTQPEGRAKATLANGHRPGQQSESPAQLPSPACTSTQWPTTKVTSGPETSPLAALEQIDHLESHSPPDLEFQPEEPEASEPSRGEDSRAVQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPALFNPYLLSLGVLRWQRPDLLNFKKGWMSILDEPGEWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDCNKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKADGPRPSLDYVELSPLAPSSPQRMRTLSRSTPERPTKQEDLERDLAQRSEERRKWFESTDGRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQAHNDRRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPESLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRRCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFTGKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEAVRNSLAE
What is the function of this protein?
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin.  The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers.  May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.
What are the official names of this protein?
TRIO and F-actin-binding protein, Protein Tara, Trio-associated repeat on actin.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton. Note=Localized to F-actin in a periodic pattern. SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-445 and lasts from prophase to anaphase. At telophase, relocalizes to midbody (By similarity).
Protein: FADH2_SCHPO
Sequence: MQQSPTAGKIINCKAAVAWQPAAPLSIENVQVFPPRVHEVRIKIVNSGVCHTDAYTLSGKDPEGLFPVILGHEGAGIVESVGPQVTTVQVGDPVIALYTPECKTCKFCKSGKTNLCGRIRTTQGKGLMPDGTSRFSCNGNTLLHFMGCSTFSEYTVVADISVVAIERLAPLDSVCLLGCGITTGYGAATITADIKEGDSVAVFGLGSVGLAVIQGAVKKRAGRIFGIDVNPEKKNWAMSFGATDFINPNDLQSPIQDVLIHETDGGLDWTFDCTGNVHVMRSALEACHKGWGQSIVIGVAAAGQEISTRPFQLVTGRVWRGCAFGGVKGRSQLPDLVKEYLDHKLEIDKYITHRRPLKEINEAFTDMHNGNCIKTVLSIP
What are the official names of this protein?
Putative S-(hydroxymethyl)glutathione dehydrogenase 2, Glutathione-dependent formaldehyde dehydrogenase 2, FALDH 2, FDH 2, FLD 2, GSH-FDH 2.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Protein: ISPF_BURL3
Sequence: MDFRIGQGYDVHQLVEGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFSDTDAAFKGADSRVLLRECVARINAAGFTIQNVDSTVIAQAPKLAPHIDGMRANIAADLGLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALLVKQGG
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: Y043_TNAVC
Sequence: MTIKRNGYNEYISMSSNSSPLLLYDIISLTNGSNDNEIIINFRSHVLNSNIIELLSGAAPHYFDVRNILVRNMESQKIGASFTINSITFVSEYMQYFVLNGNENLPNVYIDERGVVAYRKVWRRFTLGSPMFVFDYDGKLVKFTIAVERAKEGITVSSILHTRVRILDANSEDDIAFISEAIVTMMIYYKNSELEISQYYAENLYDELPRVRVLRDSKRIRNKTARRIRTTSINDIRTVIPVNNYARQCNRLPMLVDSIDDVPTELRGNTIKFPLHGEGGIDKPKYVYCRYSDAPYPGMMVNNLAGASKKFPYLPCCYKTSQEVKDVNLAYSRDVMPEVSSVAPNRVQIYFNTQRLLPCNSFGRSPMCIEKFITGINYFDDRLHDDDDNDSVSEYYPTISKVTDDVNASTYYCIRGGVQKGPNSIIEAVLRSLQYLDGRDPRTLSITDSILNSERLKLRDCINVSAQELYDIPFDKRLDILSSTQTYLDGFRFVKALQYQYDVNIYIYSRNCGPVTRFIYNHNEISLKFEDNDNINKQQQQQRERNDDDDDDDDSTLVLPYHNKSSAYIDTKIHRKSIVIYIHHGTEATTNATGYPHVEYIMFRKHKKVVEKLWDVYKAMLPVNITNVYGLSYYEADNDDINETISKRVAENCRKKLYVSTGKLLKLVGENNDGDDDDSFIPKLQVLDRLGKCVQLDEYRISSLSDFIEPLPLPIVNENMFYNNPSCLTQCYGFDAAFKVDRLSRLLLYITLYEMTLTGSITSVYFTINRQRFSELICDSGCVGKLLNNGCVTLQKYTHHLVSRTTTTTTTISPSISQEDHENNIDDSNITYILVDSSDTAKRLKYNATLLIKRMTAKEIDNLKLSTHVLPLLRYERDFALSNTSHDNMVVVTSMDKFTTKSFDHRYIYKIPSTIIPNIGESLVLITNESKEQTELVTVTSIENFTRIHDHYENSDAIQFKCVVNVWSGASTWKKSV
What are the official names of this protein?
Structural protein ORF43.
What is the protein family that this protein belongs to?
Belongs to the ascovirus HvAV ORF146 family.
What are the subcellular locations of this protein?
Virion.
Protein: YCF23_PORPU
Sequence: MTISSKISSDFDKQSALKVITGLNNFNIPQIKQMALASEIAKVTYLDIVADTDIIKEVESVSKIPICVSAVKSKELLKCQKTGVNILEIGNYDCFYEQGRLFHSEEIKLISKETRNLLPHATLCVTLPHILKIEEQVKLASDLQRIGIDMIQTEGKSTSISKTDHLSGMIQKSASTFSSTYTVSSKIRLPIISASGISSLTSPIAFLYGASGIGIGSNIRRLQDIGSMVIYIYEVQAAISSNHNIQQNINHSIQSSKISHQLIPY
What are the official names of this protein?
Uncharacterized protein ycf23.
What is the protein family that this protein belongs to?
Belongs to the ycf23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: COL13_ARATH
Sequence: MEAEEGHQRDRLCDYCDSSVALVYCKADSAKLCLACDKQVHVANQLFAKHFRSLLCDSCNESPSSLFCETERSVLCQNCDWQHHTASSSLHSRRPFEGFTGCPSVPELLAIVGLDDLTLDSGLLWESPEIVSLNDLIVSGGSGTHNFRATDVPPLPKNRHATCGKYKDEMIRQLRGLSRSEPGCLKFETPDAEIDAGFQFLAPDLFSTCELESGLKWFDQQDHEDFPYCSLLKNLSESDEKPENVDRESSVMVPVSGCLNRCEEETVMVPVITSTRSMTHEINSLERNSALSRYKEKKKSRRYEKHIRYESRKVRAESRTRIRGRFAKAADP
What are the official names of this protein?
Zinc finger protein CONSTANS-LIKE 13.
What is the protein family that this protein belongs to?
Belongs to the CONSTANS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFTU_THIDL
Sequence: MAKSKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLSSKFGGEAKAYDQIDAAPEEKARGITINTAHVEYETANRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIIVFLNKCDMVDDAELLELVEMEVRELLSKYDFPGDDTPIIKGSAKLALEGDKGELGEGAILKLAEALDTYIPTPERAVDGAFLMPVEDVFSISGRGTVVTGRVERGIIKVGEEIEIVGLKPTLKTTCTGVEMFRKLLDQGQAGDNVGILLRGTKREEVERGQVLCKPGSIKPHTHFTAEVYVLSKDEGGRHTPFFNNYRPQFYFRTTDVTGAIELPKDKEMVMPGDNVSITVKLIAPIAMEEGLRFAIREGGRTVGAGVVAKIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_CHESB
Sequence: MIGKLKGVLDEIGEDHCVVDVGGVGYVAHCSARSLSTLGSVGTPVTLFIETYVREDMIRLYGFRTVLEREWFRLLQNNVQGVGAKVALSVLSTLTPSELANAIALRDIATVARAPGVGRKVAERIVTELKSKAPAFAGEAAGAIGLKQDLGEGVAPAPVSDAVSALANLGYSRDIAANAVAAALKSAGEGADTGTLIRLGLKELAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RL25_MYCTO
Sequence: MAKSASNQLRVTVRTETGKGASRRARRAGKIPAVLYGHGAEPQHLELPGHDYAAVLRHSGTNAVLTLDIAGKEQLALTKALHIHPIRRTIQHADLLVVRRGEKVVVEVSVVVEGQAGPDTLVTQETNSIEIEAEALSIPEQLTVSIEGAEPGTQLTAGQIALPAGVSLISDPDLLVVNVVKAPTAEELEGEVAGAEEAEEAAVEAGEAEAAGESE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: EFNA1_XENLA
Sequence: MMELYRAAVQLIVGVGLGVGLWLREAQGERHIVFWNSSNYRFMQEDYTVQVQLNDYLDIVCPYYEEGSVAGHTVERYTLFLVDYEEYETCKPKSKDQVRWECNKPFAPHGPEKFCEKFQKFTPFTLGTEFREGRTYYYISKPIHYHGETCMRLRVHVSGRTTPPPVNVHTPRSHIQSDEPEVPLPGVMKSVAGNSAAPGTPCTLYGLLLAALLLRL
What is the function of this protein?
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.  Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
What are the official names of this protein?
Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1, LERK-1, xELF-a.
What is the protein family that this protein belongs to?
Belongs to the ephrin family.
What are the subcellular locations of this protein?
[Isoform A]: Membrane; Lipid- anchor, GPI-anchor.
Protein: RSMH_PHYAS
Sequence: MTLRHISVLKEEAISFLNINPNGVYVDATLGQGGHTLSILNHLQDGFLYSFDQDLKACSDIQKKLNPNWPIEIIHSNFSNLKLELAKRNVFQLDGILFDLGISSCQIDDSQRGFSYLHNAPLDMRFDNRQKLTAQEIVNFYSFEKLKNIFHIYGEEKKAALIAKQIIKNRPLKTSYDLVAITDMFYKYHKGHSAKKIFQALRIEVNQELEVLKQALSQSLELLKKDGSIVVISFHSLEDRIVKHFFKKNSVFEFPKKLPIMSVDYPQPALRIITKKPCIPSEVEMKNNPRSISAKLRAAVKNI
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_PSELT
Sequence: MAKKVVAEVKLQLPAGKATPAPPVGPALGQRGVNIMEFCKRFNAETADKAGMILPVIITVYEDRSFSFVVKTPPASFLLKRAAGLEKGSGEPKRKNVGKVTRKQLEEIAKIKMPDITANDLEAAVKIVEGTAKSMGIEIVD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ATPB_WHIBI
Sequence: MRINPTNSGFGVSTIGEKNLGRIAQLIGPVLDVVFPLGKMPNNYNALVVKGRDTVDQQINVTCEVQQLLGNNRVRALAMSATDGLTRGMEVIDTGAALSVPVGGATLGRIFNVLGEPVDNLGPVDTRTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEKNIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLTETIRGFQLILSGELDGLPEQAFYLVGNIDEATAKAMNLEKESNLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: PKHG6_HUMAN
Sequence: MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV
What is the function of this protein?
Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation.  Also activates RHOG.  Does not activate RAC1, or to a much lower extent than RHOA and RHOG.  Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis.  In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole.  Along with EZR, required for normal macropinocytosis.
What are the official names of this protein?
Pleckstrin homology domain-containing family G member 6, PH domain-containing family G member 6, Myosin-interacting guanine nucleotide exchange factor, MyoGEF.
What are the subcellular locations of this protein?
Cell projection, microvillus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow (PubMed:16721066). In epithelial cells, recruited to the apical membrane by EZR where it participates in macropinocytosis (PubMed:17881735).
Protein: KCNH2_CAVPO
Sequence: AVWDWLILLLVIYTAVFTPYSAAFLLKEPEEDAQTADCGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY
What is the function of this protein?
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel.  Channel properties are modulated by cAMP and subunit assembly.  Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).
What are the official names of this protein?
Potassium voltage-gated channel subfamily H member 2, Ether-a-go-go-related gene potassium channel 1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, gp-erg, Voltage-gated potassium channel subunit Kv11.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UVRB_PROM4
Sequence: MHKYHLNSPYLPKGDQPKAISELVYGVNQGKQYQTLLGATGTGKTFTIANVIEQTGRPTLVLAHNKTLAAQLCNELREFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTSSVNEEIDMLRHSATRSLFERRDVIVVASISCIYGLGIPSEYLKASVKFQLGNDINVRESLRELVSNQYVRNDVDISRGNFRIKGDVLEIGPAYEDRLVRIELFGDEVEAIRYVDPITGEILENLNSINIYPAKHFVTPKDRLLIAIQSIQKELKDQLDFFNQEGKLLEAQRLEQRTKYDIEMLKEVGYCNGVENYARHLSGRDQGTPPECLIDYFPEDWLLVVDESHVTCSQLQAMYNGDQSRKKVLIDHGFRLPSAADNRPLKSDEFWSKAKQTVFISATPGDWECEVSTDGIVEQVIRPTGVLDPVVEVRPTAGQIDDLLDEIRKRVIKKERVLITTLTKRMAEDLSDYLSENRVKVRYLHSEIHSIERIEIIQDLRVGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAKRSLIQTIGRAARHVDGFALLYADNLTESMSTAIQETERRRAIQQAYNQKHGIIPKPAGKKPSNSILSFLELSRKLQNEGDNADLVSITSKAVDSLNQSEDLGIAFVELPEIIDKLEGKMNLAAEELDFEQAAKLRDRIRQLRKKLSKPE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_DESAP
Sequence: MTLSADKKQPIIDKFKLHENDTGSPEVQVAILTERINLLTEHLKTHRKDFHSRRGLLKMVGQRRALLNYLRDRAPDRYRKLIQELGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: DRE1F_ORYSJ
Sequence: MDTEDTSSASSSSVSPPSSPGGGHHHRLPPKRRAGRKKFRETRHPVYRGVRARAGGSRWVCEVREPQAQARIWLGTYPTPEMAARAHDVAAIALRGERGAELNFPDSPSTLPRARTASPEDIRLAAAQAAELYRRPPPPLALPEDPQEGTSGGGATATSGRPAAVFVDEDAIFDMPGLIDDMARGMMLTPPAIGRSLDDWAAIDDDDDHYHMDYKLWMD
What is the function of this protein?
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'.  Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription (By similarity).
What are the official names of this protein?
Dehydration-responsive element-binding protein 1F, Protein DREB1F, Protein C-repeat-binding factor 2, rCBF2.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYKC_YEAST
Sequence: MSQQDNVKAAAEGVANLHLDEATGEMVSKSELKKRIKQRQVEAKKAAKKAAAQPKPASKKKTDLFADLDPSQYFETRSRQIQELRKTHEPNPYPHKFHVSISNPEFLAKYAHLKKGETLPEEKVSIAGRIHAKRESGSKLKFYVLHGDGVEVQLMSQLQDYCDPDSYEKDHDLLKRGDIVGVEGYVGRTQPKKGGEGEVSVFVSRVQLLTPCLHMLPADHFGFKDQETRYRKRYLDLIMNKDARNRFITRSEIIRYIRRFLDQRKFIEVETPMMNVIAGGATAKPFITHHNDLDMDMYMRIAPELFLKQLVVGGLDRVYEIGRQFRNEGIDMTHNPEFTTCEFYQAYADVYDLMDMTELMFSEMVKEITGSYIIKYHPDPADPAKELELNFSRPWKRINMIEELEKVFNVKFPSGDQLHTAETGEFLKKILVDNKLECPPPLTNARMLDKLVGELEDTCINPTFIFGHPQMMSPLAKYSRDQPGLCERFEVFVATKEICNAYTELNDPFDQRARFEEQARQKDQGDDEAQLVDETFCNALEYGLPPTGGWGCGIDRLAMFLTDSNTIREVLLFPTLKPDVLREEVKKEEEN
What are the official names of this protein?
Lysine--tRNA ligase, cytoplasmic, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_BIFAA
Sequence: MSTMFLRTLREDPADADVVSDKLLQRACYLRKAAPGIWTWLPLGLNVLNKIENIIREEMASIDAQEVHFSGLLPREPYEATHRWEEYGDNIFRLKDRHEADYLLAPTHEEMFTLLVKDLYSSYKDLPVTLYQIQTKYRDEFRPRAGLIRGREFIMKDAYSFTLDKEGLVKAYMDERGAYERIFNRLDLKYVPVHAMAGPMGGFESEEFLAPMEIGEDTFAQSPSGKAWNVEALTTPEPEAIDFTATPAAEKRPTPDAATIDKMVEFANANHPRSDGRDWQASDILKNVVIAVMHPQDEDHDEPWRELVVVGVPGDRTVDMKRLEAQFTPAEIEEATDEDLKKHPELVKGYIGPMALGPQARDGKKAENASETGDALRYLIDAHVARGSAWFTGADEQDVDYYDLVYGRDFEADGTVEAVQVRHGDMSPDGSGPLSFERGVEIGQVFQLGLKYSNALGLKVLDQNGKTVPVWMGSYGIGVSRVMACIAETHHDEKGLAWPAVIAPAQVHVVATGKDAAAFEAAEQLIGELEAKGIEVIFDDRKKVSPGVKFKDAELIGVPIIAVAGRDTVNNGTIEVRDRNGENAEAVPVADAAQAIADRVAALLK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.