PharMolix/UniProtQA huggingface dataset:
Protein: SYK_STRSY
Sequence: MSTEHFEELNDQQIVRREKMTALAEQGIDPFGKRFERSANSAELKAQYEDKSKEDLEELGQTAIIAGRIMTKRGKGKAGFAHIQDREGQIQIYVRKDDVSEENYEIFKKADLGDFIGVEGDVFKTNVGELSIHARKLTHLSKALRPLPEKFHGLTDIETRYRKRYLDLITNRESFDRFVTRSKIISEIRRYLDGLGFLEVETPVLHNEAGGAAARPFITHHNAQNIDMVLRIATELHLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQAYADYQDIMDLTEGIIQHTAKAVVGDGPVTYQGTEIAIHEPFKRIHMVDAIKEQTGVDFWQEMSFEEAKALAAEHKVPVEKHHTEVGQIINSFFEEYVEATLIQPTFVYGHPVAVSPLAKKNDEDPRFTDRFELFIMTKEYGNAFTELNDPIDQLERFEAQAKAKELGDDEATGVDYDYIEALEYGMPPTGGLGIGIDRLCMLLTDTTTIRDVLLFPTMK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JPH2_MOUSE
Sequence: MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPAADGPMLPSPPVPRGGFALTLLATAEAARPQGLFTRGTLLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDAAAPFDADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKYRHNVLVKGTKRRVLPLKSSKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLAKELAPDFYQPGPEYQKRRLLQEILENSESLLEPPERGLGTGLPERPRESPQLHERETPQPEGGPPSPAGTPPQPKRPRPGASKDGLLSPGSWNGEPGGEGSRPATPSDGAGRRSPARPASEHMAIEALQPPPAPSQEPEVAMYRGYHSYAVRTGPPEPPPLEDEQEPEPEPEPEVRRSDSAPPSPVSATVPEEEPPAPRSPVPAKQATLEPKPIVPKAEPKAKARKTEARGLSKAGAKKKGRKEVAQAKEAEVEVEEVPNTVLICMVILLNIGLAILFVHLLT
What is the function of this protein?
Transcription repressor required to safeguard against the deleterious effects of cardiac stress (PubMed:30409805).  Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes (PubMed:30409805).  Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis (PubMed:30409805).  Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress (PubMed:30409805).  Probably acts by competing with MEF2 transcription factors and TATA-binding proteins (PubMed:30409805).
What are the official names of this protein?
Junctophilin-2, JP-2, Junctophilin type 2.
What is the protein family that this protein belongs to?
Belongs to the junctophilin family.
What are the subcellular locations of this protein?
[Junctophilin-2]: Cell membrane; Peripheral membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (PubMed:10949023). In heart cells, it predominantly associates along Z lines within myocytes (PubMed:10949023). In skeletal muscle, it is specifically localized at the junction of A and I bands (PubMed:10949023). SUBCELLULAR LOCATION: [Junctophilin-2 N-terminal fragment]: Nucleus. Note=Accumulates in the nucleus of stressed hearts.
Protein: SAK_STAAR
Sequence: MLKRGLLFLTVLLLLFSFSSITNEVSASSSFDKGKYKKGDDASYFEPTGPYLMVNVTGVDGKGNELLSPHYVEFPIKPGTTLTKEKIEYYVEWALDATAYKEFRVVELDPSAKIEVTYYDKNKKKEETKSFPITEKGFVVPDLSEHIKNPGFNLITKVIIEKK
What is the function of this protein?
Potent plasminogen activator that converts plasminogen into plasmin.  It forms a 1:1 complex with plasmin, which in turn activates other plasminogen molecules (By similarity).
What are the official names of this protein?
Staphylokinase.
What is the protein family that this protein belongs to?
Belongs to the staphylokinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZFN2A_HUMAN
Sequence: MEFPDLGKHCSEKTCKQLDFLPVKCDACKQDFCKDHFPYAAHKCPFAFQKDVHVPVCPLCNTPIPVKKGQIPDVVVGDHIDRDCDSHPGKKKEKIFTYRCSKEGCKKKEMLQMVCAQCHGNFCIQHRHPLDHSCRHGSRPTIKAG
What are the official names of this protein?
AN1-type zinc finger protein 2A.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: G1PDH_THEVO
Sequence: MEFQKYRTMHFPRDVYIGHDVLNRVLDVVDQNSRTRDVIIVTGNTTYELAGKKIVEILASSPYEVHLSFAGEANYENLKKIEEETNDVNAGIIIGVGGGTKIDLAKKLAYDKNLPFISIPTSPSHDGIASPRASLRRNGISYSEEGAMPIGVIADTSVMIKAPYRYLAAGAADVISNISAVKDWKLAHRLRGEEFSSSAAAMSEYSAQEVISQVGEIRKYDESSVWLVTKNILASGTAMAIAGNSRPGSGSEHLFAHALEAAGVNNMLHGEMCAMGTIVSLYLHDDNWQKIRDVFESLGVSVKARDYGLKEEVVIEALRRAHAIRPERYTILGESDMSYDAAVKALELTGII
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F90AR_HUMAN
Sequence: MARHSVHHQAQRPPRAKNPQEQQRRPMGQTTLPAEQEESRVKCKNCGAFGHSARSKTCPIKRWSGALPLQALGSHKEKENLKPAKAQLPFTTPGPFTTNDREKERSPSPQQQQSEAPTQTFPRTPQEKMQEAWKEPAEDCLFLRHPTMPLPVHTTKKRSVLGPVSTGPPPVNKPEMRLLCPSGHNDSPQLSTCGPTKGHGRDVTASLLPVLKSSHQTPTLSARLPANRPDMSSHGALQPAMQALALGPGLKSQAEIKHPDADAKPRPQQVRKQCGQDSRTQAPDKEPAPVPTQTFQNPAKKARFSSFQTPALRTQLPDVGAVQTLQPPRTATGLGSKEAPKATAETAATKTATLQPRVNLQPAPSSPFLGPAQGCPVLQPGPPIHVPGRPGSVTFMRGDKGQKSPRFRMPPTSRPPENSASAQSPRFSRQPEGQGPQVSTSVLYEDLLVTSSSEDSDSD
What are the official names of this protein?
Protein FAM90A27P.
What is the protein family that this protein belongs to?
Belongs to the FAM90 family.
Protein: WRKY6_ARATH
Sequence: MDRGWSGLTLDSSSLDLLNPNRISHKNHRRFSNPLAMSRIDEEDDQKTRISTNGSEFRFPVSLSGIRDREDEDFSSGVAGDNDREVPGEVDFFSDKKSRVCREDDEGFRVKKEEQDDRTDVNTGLNLRTTGNTKSDESMIDDGESSEMEDKRAKNELVKLQDELKKMTMDNQKLRELLTQVSNSYTSLQMHLVSLMQQQQQQNNKVIEAAEKPEETIVPRQFIDLGPTRAVGEAEDVSNSSSEDRTRSGGSSAAERRSNGKRLGREESPETESNKIQKVNSTTPTTFDQTAEATMRKARVSVRARSEAPMISDGCQWRKYGQKMAKGNPCPRAYYRCTMATGCPVRKQVQRCAEDRSILITTYEGNHNHPLPPAAVAMASTTTAAANMLLSGSMSSHDGMMNPTNLLARAVLPCSTSMATISASAPFPTVTLDLTHSPPPPNGSNPSSSAATNNNHNSLMQRPQQQQQQMTNLPPGMLPHVIGQALYNQSKFSGLQFSGGSPSTAAFSQSHAVADTITALTADPNFTAALAAVISSMINGTNHHDGEGNNKNQ
What is the function of this protein?
Transcription factor involved in the control of processes related to senescence and pathogen defense (PubMed:12000796).  Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (PubMed:12000796).  Activates the transcription of the SIRK gene and represses its own expression and that of the WRKY42 genes (PubMed:12000796).  Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression (PubMed:25733771).
What are the official names of this protein?
WRKY transcription factor 6, WRKY DNA-binding protein 6, AtWRKY6.
What is the protein family that this protein belongs to?
Belongs to the WRKY group II-b family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YQGF_BURM1
Sequence: MSGTSARDATLLAFDYGEKRIGVAIGNALTRSARALVVIPNLNREHRFKAVGELLAEWRPDALVVGLPMHPDGTPHDMTQQAKRFGNQLNGRFGLPVTWVDERYSSVEAEAGMRERNVRGRARTDMLDAEAARVILQQYLDQLSDHEPH
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI10_BOVIN
Sequence: MASAASVTSLADEVNCPVCQGTLREPVTIDCGHNFCRVCLTRYLEITSPDPEEPPTCPLCKEPFRPGNFRPNWQLANVVENIERLKLVSQMDLDEEDVCPEHGEKVYFFCEDDEMQLCVVCREAWEHRAHTVRFLEDAAGPYREQIQKCLECLRKEREEIQEIQSRENRRIQVLLTQVATKKQKVISEFAHLSQFLEEQQNILLDQLEKLDEDILKHRDEFDVLVTGEIGRFNTLIEELEEKKERPARELLTDIRSTLIRCETRRCRKPVAISPELGQRIRDFPQQAFPLQREMKMFLEKLSFELDYEPAHISLDPRTSHPKLLLSEDYQQARFSYKWQKSPDNPQRFDRATCVLAHGGFTGGRHTWVVSVDLAHGGSCTLGVVSKDIRRKGELRMRPEEGVWAVRLAWGFVSALSSFPTRLTLEEQPQQVRVSIDYEVGWVTFANAVTQEPIYTFTASFTQKVFPFFGLWGRGSKFSLSSQEGAATLS
What is the function of this protein?
E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells.  May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity).  In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity.  Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (By similarity).
What are the official names of this protein?
Tripartite motif-containing protein 10.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPUS_MICLC
Sequence: MRVLTIIPTYNEIESLPLTLGRLRDAVPESDVLVVDDASPDGTGDWADTRAAEDPSVHVLHRTTKDGLGGAYIAGFRWGLERGYDVLVEMDADGSHQPEQLPRLLEAVRTADLVIGSRRVPGGKMVNWPTSRKMISWAGSLYPRIMLGLNLTDITAGYRAYRADTLRAIDLDAIESKGYGFQVDMTFRTARLGKRIVEVPITFVERELGESKMSGGIVGEAVVNVTRWGLAARWEGLRARLGL
What is the function of this protein?
Catalyzes the transfer of mannose from GDP-mannose to D-mannosyl-1-phosphoundecaprenol.
What are the official names of this protein?
Undecaprenyl-phosphate mannosyltransferase, Mannosylphosphorylundecaprenol synthase, MPUS.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: GPI15_YEAST
Sequence: MISKEYEFGKTSILNRKKYTLVIDEDKNGNFIRFTVLPVSNRKFKKVKQNGRVEINMGIQYHQIVLILLLNILFYVICLRSRFLEHINRTFEVTIARSFQILIIMGLFALGTIILVRGPSVETVTIFKESGLQLSRVKGMVIFPQQWNRKFFEQVEFISNERIIDVVINEGFCRGFRVIFYLAAIVRKSSTLKLLFPSNLPSIDDQRLIYNISRKYLSKQEKPLSRPKD
What is the function of this protein?
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
What are the official names of this protein?
Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15, GPI-GlcNAc transferase complex subunit GPI5, GPI-GnT subunit GPI5, PIGH homolog.
What is the protein family that this protein belongs to?
Belongs to the PIGH family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: UGL_BURCH
Sequence: MKLLRYGPSGQEKPGILDAAGRIRDLSAHVPDLAGDVLSDAGLARLRAIDPATLPLVSGEPRIGACVGHVGKFIGIGLNYADHAAEAGMPVPKEPVVFGKWTSSICGPNDGIDIPKGSVKTDWEVELGVVIGAKCKDVDEARALDYVAGYCVVNDVSEREWQIERGGQWDKGKGFDTFGPIGPWLVTRDEVPDPQRLDLWLEIDGHRYQNGNTRTMVFTVAQLVAYLSTCMTLQPGDVITTGTPPGVGMGVKPSPVFLKAGQTVRLGIEGLGEQLQRTRDAQ
What are the official names of this protein?
Ureidoglycolate lyase, UGL, Ureidoglycolase, Ureidoglycolatase, Ureidoglycolate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the FAH family.
Protein: SAP18_HUMAN
Sequence: MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFNFAIVFTDVKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPNRAPPPSGRMRPY
What is the function of this protein?
Component of the SIN3-repressing complex.  Enhances the ability of SIN3-HDAC1-mediated transcriptional repression.  When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins.  Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets.  The ASAP complex can inhibit mRNA processing during in vitro splicing reactions.  The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis.  Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.
What are the official names of this protein?
Histone deacetylase complex subunit SAP18, 18 kDa Sin3-associated polypeptide, 2HOR0202, Cell growth-inhibiting gene 38 protein, Sin3-associated polypeptide p18.
What is the protein family that this protein belongs to?
Belongs to the SAP18 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus speckle. Note=Shuttles between the nucleus and the cytoplasm (PubMed:16314458). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (PubMed:20966198).
Protein: COAE_MANSM
Sequence: MAYIVGLTGGIGSGKSTIADLFMELGVPVVDADEVSRRLVEKGSPLLSKIATHFGADILTNGGELNRSKLREIIFNRPEQKNWLNALLHPAINEEMQRQLQAQQAPYVLFVVPLLIENNLMSLCDRILIIDVSPQTQLERATKRDKNQRELIQQIMNSQVSREKRLTFADDIINNDEDFAQNGDRIKQKVLELHQRYLQLAQQKSSTYDNKNDR
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRRA_MYCTO
Sequence: MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFKKLGIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRIDEARIELADIALRRPSLDHVFLAMTTDPTESLTHLVSGSAR
What is the function of this protein?
Part of the ABC transporter complex DrrABC involved in doxorubicin resistance.  Responsible for energy coupling to the transport system.  Binds ATP (By similarity).
What are the official names of this protein?
Doxorubicin resistance ATP-binding protein DrrA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Drug exporter-1 (DrugE1) (TC 3.A.1.105) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL13_RHIME
Sequence: MATFVQKPAEVEKKWILIDAEGLVVGRLASLIANRLRGKHKATYTPHVDDGDNVIVINAEKAVLTGKKYTDKKYYWHTGYPGGIKERTARQIIEGRFPERVIEKAVERMVPRGPLGRRQMKNLRVYAGSNHPHEAQQPAVLDVAKLNSKNTRSA
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: NAS2_ORYSI
Sequence: MEAQNQEVAALVEKIAGLHAAISKLPSLSPSAEVDALFTDLVTACVPASPVDVAKLGPEAQAMREELIRLCSAAEGHLEAHYADMLAAFDNPLDHLARFPYYGNYVNLSKLEYDLLVRYVPGIAPTRVAFVGSGPLPFSSLVLAAHHLPDAVFDNYDRCGAANERARRLFRGADEGLGARMAFHTADVATLTGELGAYDVVFLAALVGMAAEEKAGVIAHLGAHMADGAALVVSARHGARGFLYPIVDLEDIRRGGFDVLAVYHPDDEVINSVIVARKADPRRGGGLAGARGAVPVVSPPCKCCKMEAAAGAFQKAEEFAAKRLSV
What is the function of this protein?
Synthesizes nicotianamine, a polyamine that is the first intermediate in the synthesis of the phytosiderophores of the mugineic acid type found in gramineae which serve as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron.
What are the official names of this protein?
Nicotianamine synthase 2, S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3-carboxypropyltransferase 2, OsNAS2.
What is the protein family that this protein belongs to?
Belongs to the nicotianamine synthase (NAS)-like family.
Protein: CYTR_ECO57
Sequence: MKAKKQETAATMKDVALKAKVSTATVSRALMNPDKVSQATRNRVEKAAREVGYLPQPMGRNVKRNESRTILVIVPDICDPFFSEIIRGIEVTAANHGYLVLIGDCAHQNQQEKTFIDLIITKQIDGMLLLGSRLPFDASIEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFDAVNYLYEQGHKRIGCIAGPEEMPLCHYRLQGYVQALRRCGIMVDPQYIARGDFTFEAGSKAMQQLLDLPQPPTAVFCHSDVMALGALSQAKRQGLKVPEDLSIIGFDNIDLTQFCDPPLTTIAQPRYEIGREAMLLLLDQMQGQHVGSGSRLMDCELIIRGSTRALP
What is the function of this protein?
This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins.  Binds cytidine and adenosine as effectors (By similarity).
What are the official names of this protein?
HTH-type transcriptional repressor CytR.
Protein: CBRA_ECO57
Sequence: MEHFDVAIIGLGPAGSALARKLAGKMQVIALDKKHQHGTEGFSKPCGGLLAPDAQRSFIRDGLTLPVDVIANPQIFSVKTVDVAASLTRNYQRSYININRHAFDLWMKSLIPASVEVYHDSLCRKIWREDDKWHVIFRADGWEQHITARYLVGADGANSMVRRYLYPDHQIRKYVAIQQWFAEKHPVPFYSCIFDNAITDCYSWSISKDGYFIFGGAYPMKDGQTRFTTLKEKMSAFQFQFGKAVKSEKCTVLFPSRWQDFVCGKDNAFLIGEAAGFISASSLEGISYALDSAEILRSVLLKQPEKINAAYWHATRKLRLKLFGKIVKSRCLTAPALRKWIMRSGMAHIPQLKD
What are the official names of this protein?
Protein CbrA.
What is the protein family that this protein belongs to?
Belongs to the CbrA family.
Protein: PIGZ_DROME
Sequence: MRLTTLWQNRSPGDRHLSTYFCFAAVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFRLEHTRTWEFNNSLPVRSIVLPFALLRIPWSFYEFVAECLKAWWQLELLGTYAYVVFPRLIYTLISFSNDYCLFRICRLYGLRFEIRLLAMGSSWILLVFGTRTFSNSLEMAMCSWLLCLVSECMLRTNTVVYKKEFLEEKYDKAESISERVRIWKLKNSLPAHNLQHLMAMSTICVAGVFNRPTFLLFGAPMVFFWLLRGMGTRSITFRDFNLRIALFCLCALPALVLFIFCDSLYYQHLTLGELHMMHLSIDNFVFTPWNFIKANLDSAQTASHGVHPCYVHLMVNMPMLFNVLALASLGAFAQLLLRFFRAEYQVLPRFQSIVSLMSGAIFVPLFFLSLINHQEPRFLLPVTFPLILLHAPKLITGFSAKYPFQKDHPLLRLFYDKLLSSKASGPYLLKIWYVSNVALTLFFGFIHQAGVYPLAADISHVIATKPAATHVHLITSHIYSLPLHLINIPSSRVLHFNRLTHQRYRRPRDFYMYEYGGLPLDSLLQKVKLISGSCEVKKSGPSRRRYKLYLAIPASLSADLHEALVHSNASSYLNFELLKVFYPHLSTEAFPHLQGRHPCDVDAPHWAHDDLRGTCSAEQLPAFSFAYLNKQFSSFVHQLGLALYEIDVTRNKPRSVVIKKASMTETAA
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 4, GPI mannosyltransferase IV, GPI-MT-IV, Phosphatidylinositol glycan anchor biosynthesis protein class Z.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 22 family. PIGZ subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CRK19_ARATH
Sequence: MSSLISFIFLFLFSSITASAQNTFYLYHNCSVTTTFSSNSTYSTNLKTLLSSLSSLNASSYSTGFQTATAGQAPDRVTGLFLCRVDVSSEVCRSCVTFAVNETLTRCPKDKEGVFYYEQCLLRYSNRNIVATLNTDGGMFMQSARNPLSVKQDQFRDLVLTPMNLAAVEAARSFKKWAVRKIDLNASQSLYGMVRCTPDLREQDCLDCLKIGINQVTYDKIGGRILLPSCASRYDNYAFYNESNVGTPQDSSPRPGKGGNSSVIIIAVVVPITVLFLLLVAVFSVRAKNKRTLNEKEPVAEDGNDITTAGSLQFDFKAIEAATNCFLPINKLGQGGFGEVYKGTLSSGLQVAVKRLSKTSGQGEKEFENEVVVVAKLQHRNLVKLLGYCLEGEEKILVYEFVPNKSLDHFLFDSTMKMKLDWTRRYKIIGGIARGILYLHQDSRLTIIHRDLKAGNILLDDDMNPKIADFGMARIFGMDQTEAMTRRVVGTYGYMSPEYAMYGQFSMKSDVYSFGVLVLEIISGMKNSSLYQMDESVGNLVTYTWRLWSNGSPSELVDPSFGDNYQTSEITRCIHIALLCVQEDAEDRPTMSSIVQMLTTSLIALAEPRPPGFFFRSKQEQAGPSIDSSTHCSVDEASITRVTPR
What are the official names of this protein?
Cysteine-rich receptor-like protein kinase 19, Cysteine-rich RLK19.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PILR1_LINCY
Sequence: MGSLNESSKVLVIGGTGYLGKRLVKASLDAGHDTYVMHRPEIGVDIEKVQLLLSFKMQGAHLVSASFDDHRSLVDAVSLVDVVICAISGVHIRSHQILLQLKLVQAIKEAGNVKRFLPSEFGTDPARMGDAMEPGRVTFDDKMVVRRAIEEAAIPFTYVSANCFAGYFLGGLCQPGSILPSRDHVTLLGDGNQKGVYVDENDIAAYTLKAIDDPRTLNKTLYIKPPKNILSQRQVVGIWEKHIGKQLHKTLLSEQDFLAAMKEQDYAEQVGLTHYYHVCYEGCLTNFEVEQDQEASKLYPDVRYTTVEEYLKRYV
What is the function of this protein?
Reductase involved in lignan (-)-hinokinin biosynthesis.  Catalyzes the enantioselective conversion of (+)-pinoresinol into (+)-lariciresinol and of (+)-lariciresinol into (-)-secoisolariciresinol.  Abstracts the 4R-hydride from the NADPH cofactor during catalysis.  Has also a low phenylcoumaran benzylic ether reductase activity.
What are the official names of this protein?
Bifunctional pinoresinol-lariciresinol reductase, PLR-Lc1, (+)-lariciresinol reductase, (+)-pinoresinol reductase.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: SYN_ALKOO
Sequence: MKSILVKDIYRNTEKYAGQEIVIEGWIRTLRASKAFGFIEVNDGSFFKNIQVVFEEGLENFAEVSKLSISTAIIVKGKLEITPDAKQPFEIKATSIEVEGESDSDYPLQKKRHTFEFLREIAHLRPRSNTFSAVFRVRSLAAFAIHQFFQERGFVYTHTPIITGSDAEGAGEMFRITTLDPKNPGLNEAGEVDFTKDFFGKETSLTVSGQLQGEAYALAFRNIYTFGPTFRAENSHTARHASEFWMIEPEIAFADLQDNMELAEEMLKYIINYVMENAPEEMEFFNSFVDKGLLDRLNNVATSDFGRVTYTEAIEILQKSGETFEYPVAWGTDLQTEHERYLTEKVFKKPVFVTDYPKDIKAFYMKLNEDGKTVAAMDLLVPGIGEIIGGSQREDNLALLEERMDAMGLDKEEYWWYLELRKYGSARHAGYGLGFERAIMYLTGMSNIRDVISFPRTPKSAEF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRBF2_HUMAN
Sequence: MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKAAAYLSEAMKLTQSEQAHLSLELQRDSHMKQLLLIQERWKRAQREERLKAQQNTDKDAAAHLQTSHKPSAEDAEGQSPLSQKYSPSTEKCLPEIQGIFDRDPDTLLYLLQQKSEPAEPCIGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGPIEKELDVDADFVETSELWSLPPHAETATASSTWQKFAANTGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGFMNN
What is the function of this protein?
Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1).  However, effects has been described variably.  Involved in the induction of starvation-induced autophagy (PubMed:24785657).  Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity).  Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043).  May be involved in autophagosome biogenesis (PubMed:25086043).  May play a role in neural progenitor cell survival during differentiation (By similarity).
What are the official names of this protein?
Nuclear receptor-binding factor 2, NRBF-2, Comodulator of PPAR and RXR.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome.
Protein: SYS_RICAH
Sequence: MLSIKWIRENQELFDEKLSKRFIEPMSSKIAMLDGEKRKITSLIQEFQHARKVKSKILGNMASKSGEEFEAIQRDVKHINEKLEELEQDLNNNNELNELLNMLPNIPDEEVPYGMDESMNKLVRTYGETNPNALNKQHFELGTKLNLMDFEQTAKISGARFVTLKGDLAKLERALINFMIDVHTKEFNFFEMSPPVLVRDNAMYNSGQLPKFAEESFATTNGYRLIPTAEVFLVNIVADTIIPREKLPMRYVAYTPCFRSEAGSSGRDTRGMIRLHQFGKVELVSITTPEESKHEHEYITNSSETILQKLNLPYRVMLLCTGDMGFAAKKTYDIEVWLPGQKQYREIASCSNCGDFQARRMKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNEDGSITIPDVLINYMGGLQKITTHGE
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.