PharMolix/UniProtQA huggingface dataset:
Protein: EFTU2_XANCB
Sequence: MARAKFLREKLHVNVGTIGHVDHGKTTLTAALTKIGAERFGGEFKAYDAIDAAPEEKARGITISTAHVEYESAVRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPHIVVFLNKADMVDDAELLELVEMEVRELLSKYDFPGDDTPIIHGSARLALEGDQSDIGVPAILKLVEALDTFIPDPTRDVDRPFLMPVEDVFSISGRGTVVTGRIERGIIKVGDEIEIVGIRDTQKTTVTGVEMFRKLLDQGQAGDNAGLLLRGTKRDDVERGQVLCKPGSIKPHTEFEAEVYVLSKDEGGRHTPFFKGYRPQFYFRTTDITGACQLPEGVEMVMPGDNVKMVVTLINPVAMDEGLRFAIREGGRTVGAGVVAKIIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_METB6
Sequence: MLEIRFVRASPDVVKADLERRGTPEKIAWVDEILAKDARSRELKVQTDELRRRRNTIAREINEARKTGKDAAPLLREAAELPQKIKANDAEQEEISGIIRTRLMRLPNILHESVPKGKDDTENVEIRRVGTPRTFDFELKNHGQLAADNGWADFERAAKTSGAGFYFLKGGLVMLDLALQRFALDLLGKKGFTPVIPPFMIKRDSYEGVTDLDDFEKVMYKIDGDDTYLIATSEHPIAAMYQDEIFEEKDLPLRLCGLSPCFRREIGAHGLDTKGLFRVHQFTKIEQFVFCRPENSWQIHEELLANAEEVFTKLGLPYHVVNICTGDIGTVAAKKYDIEAWMPRENAYKEVVSCSNCTSYQAASLNIRVRDKENFETKHLVHTLNSTAIATSRALRCILENYQNRDGSVTIPDVLRQYMNDREFL
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_AERS4
Sequence: MAKVSMRDMLQAGVHFGHQTRYWNPKMKSYIFGARSKVHIINLEKTVPMFDDAMNFISSVAAKKGKVLFVGTKRAASEAVKDAAGRCDQFYVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFEKLTKKEALMRTREMDKLEKSLGGIKNMGGLPDVLFVVDADHEHIAIKEANNLGIPVVSIVDTNSNPDGVDYVIPGNDDAIRAVQLYLNAAADTVLEARAQDIVVQAEQDGFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: THIC_RHOPS
Sequence: MNIRSNPDTTRPAVTTGGLPSSKKIYATPAAAPDLRVPLREIILSEGAGEPNLPIYDTSGPYTDPSVTIDVNAGLSRARTQWVKERGGVEEYQGRDVKPEDNGNVGAAHAAKSFTAYHKPLRGIGDAPITQYEFARRGIITKEMIYVAERENLGRKQQLERAEAALADGESFGASVPAFITPEFVRDEIARGRAIIPANINHGELEPMIIGRNFLTKINANIGNSAVTSSVEEEVDKMVWAIRWGADTVMDLSTGRNIHTTREWILRNSPVPIGTVPIYQALEKCEGDPVKLTWELYKDTLIEQCEQGVDYFTIHAGVRLQYIHLTANRVTGIVSRGGSIMAKWCLAHHKESFLYTHFDEICDLMRKYDVSFSLGDGLRPGSIADANDRAQFAELETLGELTKIAWAKGCQVMIEGPGHVPMHKIKINMDKQLKECGEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGCAMLCYVTPKEHLGLPDRNDVKVGVITYKIAAHAADLAKGHPAAQLRDDAVSRARFDFRWQDQFNLGLDPDTAQAFHDETLPKDAHKVAHFCSMCGPKFCSMKITQDVRDYAAGLGDNEKAALYPAGSVGMSISGVIEDGMAQMSAKFRDMGEHLYLDAEKVKESNKALS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: PURA_ASPFU
Sequence: MGITIVLGSQWGDEGKGKITDMLSQQATLCCRAAGGHNAGHTIVHENITYDFHILPSGLVSPSCVNLIGAGTVVHVPSFFKELASLEEKGLKDAGKRIFISDRAHVCFDLHSIVDGLEEAKLGGRKVGTTGKGIGPCYSDKAARRGVRIGEVLDEAVFERKLRSLHAGYTARFGELQYDVEEEIGRFKDYRKRLVPYIVDQLAFFKQYKDSPNTLVEGANALMLDLDHGTYPYVTSSSTGLGGAVQALSLNPTSITSVIGVVKAYTTRVGSGPFPSEQLNEYGDKLQSVGREFGVTTGRRRRCGWFDLVLCRYSQAINHYTALNLTKLDILDDFDEIKVAVAYVLPDGTRLTDTYPADPEVLEKVKVEYVTLPGWKSNTMGVKKYEDLPANARAYIEYIERELGGVPIKWIGTGPARDHMICRE
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2AY_TETTS
Sequence: MSTDQEKIIKQVLDSIAEQQGDSRDDEVYVIEIMSLRFEKFDNRIKQKIERFTSLQMLTINDCLISDLTNFPHVPSLIRLDLVFNKITGDQLQYLRGSRHLQTLMLGANQIEEIEDLKRLGQMRELIQLDLLNNPVVNTNNYRNLVFNLFPSLVILDTLDKNGIDQEKAALDISASRVPDNLFDKSKPVQNVSKQVVKNAKATQNNLFSSTQKVAQVKQIPKIVPAKVSKPSQASVQDNKSNVVQAKVTAAVSVGRKAPASRNGGVPSKAGKGKMNAFSKQSTSQKSGLVFPCGRLRRYLKQACKQFRVSSSCNIYLAGVLEYLAAEVLETAGNIAKNNRLSRINPVHIREAFRNDAELNQFVNGTIIAEGGSTSTNFVLPIINKSKK
What is the function of this protein?
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
What are the official names of this protein?
Histone H2A.Y.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL30_ALBFT
Sequence: MTTQQTIKVQLIRSPIGCQESHRATVRGLGLRKIRSTSELVDTPEVRGMINKISYLIKVL
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: KPSM5_ECOLX
Sequence: MARSGFEVQKVTVEALFLREIRTRFGKFRLGYLWAILEPSAHLLILLGIFGYIMHRTMPDISFPVFLLNGLIPFFIFSSISNRSVGAIEANQGLFNYRPVKPIDTIIARALLETLIYVAVYILLMLIVWMAGEYFEITNFLQLVLTWSLLIILSCGIGLIFMVVGKTFPEMQKVLPILLKPLYFISCIMFPLHSIPKQYWSYLLWNPLVHVVELSREAVMPGYISEGVSLNYLAMFTLVTLFIGLALYRTREEAMLTS
What is the function of this protein?
KpsM and KpsT constitute a system for the transport of polysialic acid across the cytoplasmic membrane.
What are the official names of this protein?
Polysialic acid transport protein KpsM.
What is the protein family that this protein belongs to?
Belongs to the ABC-2 integral membrane protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL7_PSEPW
Sequence: MSLTNEQIIEAIGQKTVLEVVELIKAMEETFGVTAAVAAAGPAAAAAVVEEQTEFNVVLVEAGDKKVNVIKAVRELTGLGLKEAKEKVDGAPQVVAEGVSKEAAEDAKKKLEEAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: LYSC_SEMEN
Sequence: MKALTILGLVLLSVTVQGKIFERCELARTLKKLGLDGYKGVSLANWVCLAKWESGYNTEATNYNPGDESTDYGIFQINSRYWCNNGKTPGAVDACHISCSALLQNNIADAVACAKRVVSDPQGIRAWVAWRNHCQNKDVSQYVKGCGV
What is the function of this protein?
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.  Also plays a role in digestion in this species.
What are the official names of this protein?
Lysozyme C, 1,4-beta-N-acetylmuramidase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: OXO1_HORVU
Sequence: SDPDPLQDFCVADLDGKAVSVNGHTCKPMSEAGDDFLFSSKLTKAGNTSTPNGSAVTELDVAEWPGTNTLGVSMNRVDFAPGGTNPPHIHPRATEIGMVMKGELLVGILGSLDSGNKLYSRVVRAGETFVIPRGLMHFQFNVGKTEAYMVVSFNSQNPGIVFVPLTLFGSDPPIPTPVLTKALRVEAGVVELLKSKFAGGS
What is the function of this protein?
Releases hydrogen peroxide in the apoplast which may be important for cross-linking reactions in the cell wall biochemistry.  May play an important role in several aspects of plant growth and defense mechanisms.
What are the official names of this protein?
Oxalate oxidase 1, Germin.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast. Secreted, cell wall.
Protein: RS19_ECOL5
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPLRTWSRRSTIFPNMIGLTIAVHNGRQHVPVFVTDEMVGHKLGEFAPTRTYRGHAADKKAKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: LIMD1_MOUSE
Sequence: MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGAGNNPEFEETRRVFATKMAKIHLQQQQQQQLLQEEALPRAGRSPVNGGNRQGASGKLAADGAAKPPLAVPTVAPGLATTTAAAQPSYPSQEQRIRPSAHGARPGSQNCGSREGPVSSQRPALHGLSPSCEDPSCLTHGDYYDNFSLASPQWGDKPEGCPSVSLGVGSGWPGCPGNDSTLPKSCGDHHPYQPQLSTVCSGRSFESGISGQDGGIGGHSSEKPTGLWSTASSQRVNLGFSSMGLENGTSAQPKGTTVSAPMVPSSASQGACPKRDSGLGYEASGRVFKPLVDTQPWLQDGPKSYLSVSAPLSSTAGKDSTQPGMTTGLDPKFGCVESGTSPKPSPTSNVHPVMSTPSELSCKESSPSWSTDSSLEPVLPGSPTPSRVRLPCQTLAPGPELGPSTAELKLEALTQRLEREMDAHPKADYFGSCVKCSKGVFGAGQACQAMGDLYHDACFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKRLEKGPSPAPLHQHHF
What is the function of this protein?
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration.  Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity.  Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A.  Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription.  Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.  Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements.  Regulates osteoblast development, function, differentiation and stress osteoclastogenesis.  Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts.  May act as a tumor suppressor by inhibiting cell proliferation.
What are the official names of this protein?
LIM domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the zyxin/ajuba family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions (By similarity).
Protein: YP250_YEAST
Sequence: MTTRGSNDVVHFFDLSLGSGERTQSLLGDLSGSLFTGVSDQIDQSSFIWGQTGDFSNQRSDELGSVGGSTLLVGDLWGWSHLGDFLTLVQTNSDT
What are the official names of this protein?
Putative uncharacterized protein YPL250W-A.
Protein: PYRC_CALS8
Sequence: MILIKNAQIINSLHDKVEKADILIVDDKIKKIGKDIEENPEKMTIIDASGKVVMPSFTDIHCHLREPGFEYKEDIKSGSRSAAAGGFTTICCMPNTNPPVDNRAMVAYIKYRAREVSPIEVLPVGAITKGLLGEELAEIGFMKEEGAIAISDDGKCVMNANLMKNALLYSRDFSIPVISHCEDTNLSEGGQINLGYVSTITGLRGIPREAESVIIARDILLAKETKSHLHITHVSTKESVRLIKMAKEWGVNVTADTCPHYISLTEEEVLGFNTNAKVNPPLRTQEDVEALIEGLKEGVIDCISTDHAPHHKDEKNVEFNLAASGTIGFETAFSVLFTYLVEKNGFDIGKIVELLNHNPRKIIGLSPNVLKEGEKANLVIVDLKKKWEVKEENIVSKSKNSVFLGKLLTSYVETVIYNGKILKKDGVLNC
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: RL17_SALPB
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEIVAKLFNELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRSEKTEAAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: FOLD3_PSEMY
Sequence: MNTQAPIKLIDGKAAAARVLAEVAEDVRALKAAGIVPALAVVLVGDDPASQVYVRNKVLRAEECGIRSLEFKLPADTAEARLQALIAELNADASVHGILVQLPLPAHIDEQRVLQAVTPLKDVDGFHAENVGGLSQGREVLTPCTPAGCLRLLQDSCGDLTGKHAVVIGRSNIVGKPMAALLLKAHCSVTVVHSKSANLKTLCRQADIVVAAVGRPRLVDADWLKPGAVVIDVGINRIDENGRSRLVGDVDFDSALPQVSAITPVPGGVGPMTIAYLMKNTLVAARLQQTAPSNLTQRAEAACPSIS
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 3.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: MURI_METCA
Sequence: MTGNEHPIGVFDSGVGGLSVLREIRAVLPHENLLYVADSGHLPYGNKPAEYIEQRALTVGRFLLSRGAKAIVVACNTATAAAITVMRAEFRVPVIGMEPGLKPAVALSKSLVVGVLATEGTLKSAKFRDLVGRTTEKVEVIAQACPGWVEQVERGDLGSPATRDLVRRYTEPALERGADTLVLGCTHYPFLAGLIADVAGPDVHIVETGSAVARHLRRRLEADGLLTRRMAPGVELFWSSGPAEVAGRSLAVLWPGVHRVRPLPAGFAAGD
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: GLMM_PROMP
Sequence: MQSIFGTDGIRGIFDKELTYSLAYKVGYALGVSTKTNNPILIGRDTRVSGYILIEAISRGINAAGKEFIYLGICPTPAIPFLIKKEKFSGGIMISASHNPPEYNGIKIFDNNGEKIKKKLENQIELILETANNLKLSTYKKTSIRENNNLFNIYTEGLINTMGDENLDGMKIVLDTCYGSATTCAASIFQKLGANVKVINNEQDGLKINLNCGSTCLDPIIKAIKENNADMGFSFDGDADRVIGVDSEGNIIDGDHILFLWGRELLEEKLLTNNTIISTKMANLGFENTWKKIGGILHRTEVGDKFIFEAIKKKKALLGGEQSGHILSKINDFCGDGILTAIQISKYCKKKNISLRSWLNSSFSPYPQKLTNVLLNFKFKNIDKSYKEFINETIESFSNIKKDNCRVYIRPSGTEPVLRILVEARNQQEVDSLSTKITAELSTKIYKISKTF
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: SURE_HALMA
Sequence: MDEPTILLTNDDGIESAGLRAVYDGLSTVGDVTAVAPAEDQSAVGRAISHEVTVHEHELGYAVEGTPSDCVVAGLEALVTDTDLVVAGCNRGANLGAYVLGRSGTVSAAVEATFFDVPAMAVSMYIPVREDAAFADIEANGDSYREAAKATTYLADHAVDAGVFEQCDYLNINAPVAEWGDAQMTVTRPSHLYEMDAEQDGDAVTLHDRIWEHMADGDIPDPEGTDRRAVVDGKVSVSPLTAPHTTEHHEALDAIAETYEPDDGGEAAD
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBLK3_ARATH
Sequence: MVRLDLPWDLVDEILSRLPATSLGRLRFTCKRWNALFKDPEFITKQFHKAAKQDLVLMLSNFGVYSMSTNLKEIPNNIEIAQVFHCNGLLLCSTEEGNKTKLVVVNPCTGQTRWIEPRTDYNYNHDIALGYGNNSTKKSYDSYKILRITYGCKLVEIFELKSNSWRVLSKVHPNVEKHYYGGVSFKGNTYWLSYTKFNILSFDFTTETFRSVPLPFLYQDGFVTLALSVVREEQLLLLRSRFDMGQVGIWMCNKIDTETVLSWSKSFTLEFDSLRDLPVMSILRIFIEEDKKVIVVDCDDRWKENMIYIVGKNGFKKLSYEKDRSNLWRLPFFFSYVPSLVGLYPPM
What are the official names of this protein?
F-box/LRR-repeat/kelch-repeat protein At2g27520.
Protein: MAP7_HUMAN
Sequence: MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI
What is the function of this protein?
Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells.  Associates with microtubules in a dynamic manner.  May play a role in the formation of intercellular contacts.  Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.
What are the official names of this protein?
Ensconsin, Epithelial microtubule-associated protein of 115 kDa, E-MAP-115, Microtubule-associated protein 7, MAP-7.
What is the protein family that this protein belongs to?
Belongs to the MAP7 family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike- like bundles facing intercellular contacts.
Protein: IL8_PIG
Sequence: MTSKLAVAFLAVFLLSAALCEAAVLARVSAELRCQCINTHSTPFHPKFIKELRVIESGPHCENSEIIVKLVNGKEVCLDPKEKWVQKVVQIFLKRTEKQQQQQ
What is the function of this protein?
Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection.  Also plays an important role in neutrophil activation.  Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells.  G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
What are the official names of this protein?
Interleukin-8, IL-8, Alveolar macrophage chemotactic factor I, AMCF-I, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PURA_MYCTA
Sequence: MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGENFALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLISADAHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDPEQLTHKVEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHRIADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFGVTTGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEIDGRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLRLEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOZB_BACSU
Sequence: MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIHILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAENTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLWLYVSLTGVIVYLMISPYY
What are the official names of this protein?
Uncharacterized membrane protein YozB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PG2B1_ARATH
Sequence: MSSTSSSQMVQLVADKHVRYILMAEKKKESFESVVMDHLRMNGAYWGLTTLDLLDKLGCVSEEEVISWLMTCQHESGGFAGNTGHDPHILYTLSAVQILALFDKINILDIGKVSSYVAKLQNEDGSFSGDMWGEIDTRFSYIAICCLSILKCLDKINVEKAVKYIVSCKNLDGGFGCTPGAESHAGQIFCCVGALAITGSLHHVDKDSLGWWLCERQLKAGGLNGRPEKLADVCYSWWVLSSLIMIDRVHWIDKAKLVKFILDCQDLDNGGISDRPEDAVDIFHTYFGVAGLSLLEYPGVKVIDPAYALPVDVVNRIIFTK
What is the function of this protein?
Required for male fertility and root tip growth.
What are the official names of this protein?
Geranylgeranyl transferase type-2 subunit beta 1, Geranylgeranyl transferase type II subunit beta 1, Rab geranylgeranyl transferase beta subunit 1, AtRGTB1, Rab-GGT beta 1.
What is the protein family that this protein belongs to?
Belongs to the protein prenyltransferase subunit beta family.
Protein: FLT3_HUMAN
Sequence: MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells.  Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR.  Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1.  Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B.  Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B.  Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
What are the official names of this protein?
Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.