PharMolix/UniProtQA huggingface dataset:
Protein: IPYR_PSEPK
Sequence: MSYSKIPAGKDLPNDIYVAIEIPANHAPIKYEIDKDSDTLFVDRFMATPMFYPANYGFIPNTLADDGDPLDVLVVTPYPVAPGSVIRARPVGVLNMTDDGGGDAKVIAVPHDKLSQLYVDVKEYTDLPALLIQQIEHFFANYKDLEKGKWVKIEGWEGADAARAAITKSVAAYKG
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_STRPI
Sequence: MSRKPFIAGNWKMNKNPEEAKAFVEAVASKLPSSDLVEAGIAAPALDLTTVLAVAKGSNLKVAAQNCYFENAGAFTGETSPQVLKEIGTDYVVIGHSERRDYFHETDEDINKKAKAIFANGMLPIICCGESLETYEAGKAAEFVGAQVSAALAGLTAEQVAASVIAYEPIWAIGTGKSASQDDAQKMCKVVRDVVAADFGQEVADKVRVQYGGSVKPENVASYMACPDVDGALVGGASLEAESFLALLDFVK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCXP_RHOJU
Sequence: KEGYPKNSEGCKITCLFNDPYCKGLCINLSTQADY
What is the function of this protein?
Causes paralysis and death in insects (A. domestica).
What are the official names of this protein?
Putative neurotoxin.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: RP19_FOWPN
Sequence: MDNSMDINDILLSDDNDYKSYDEDDDSISDIGETSDDCCTTKQSDSRIESFKFDETTQSPHPKQLSERIKAIKQRYTRRISLFEITGILSESYNLLQRGRIPLLNDLTEETFKDSIINIMFKEIEQGNCPIVIQKNGELLSLTDFDKKGVQYHLDYIKTIWRNQRKL
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF) thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase 19 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 19 kDa subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle (By similarity).
Protein: HSLU_PHEZH
Sequence: MTEFSPREIVSELDRFIVGHPEAKRAVAVALRNRWRRRRVPDDLRDEVTPKNILMIGPTGVGKTEIARRLAKLAQAPFLKVEATKFTEVGYVGRDVDQIVRDLVESAIQMVREKRRAAVRARAEAAAEERILDALTGPGSTAAREAFRRKLRAGELDDKEVELQLADTSSPFGAMDIPGQPGASMGVLNLGDMFGKAFGGRTKTHKTTVSGAWVPLIAEESDKLVDQEALTQEALELAENQGIVFLDEIDKVASRQDRAGADVSREGVQRDLLPLIEGTTVSTKHGPVKTDHILFIASGAFHVAKPSDLLPELQGRLPIRVELKALSRQDMRRILTEPEANLIRQHQALLATEGVTLTFTEDAIDALADAAVAVNGSVENIGARRLQTILEKVLEEVSFTAADRDGETITVDAAYVNGRIGDLAGNADLSKFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_CUPTR
Sequence: MTIKIAIDCMGGDHGVSVTVPAAISFLSRHDDAEMVLVGLPDAIRAQLKKLHALDHPRVSIVEATEVITMDDPVEVALRKKRDSSMRVAVTQVKEGLAGACISAGNTGALMAVSRYVLKTLEGIERPAIATTIPNEQGWGTTVLDLGANADCEPEHLLQFARMAEAMVAVVDHKEHPTVGLLNIGEEVIKGNEVVKRAGELLRASELNFYGNVEGNDIFKGTTDIVVCDGFVGNVALKSTEGLAKMIGSMIKEEFTRSWFTKLLAAVAMPVLSRLARRLDPARYNGASLLGLRGLVIKSHGSADAHSFEWAIKRGYDAAKNGVIARITRAFADKSSAAGGVQSAPETEAPGAHPSPHVA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: TRMD_MYCTU
Sequence: MRIDIVTIFPACLDPLRQSLPGKAIESGLVDLNVHDLRRWTHDVHHSVDDAPYGGGPGMVMKAPVWGEALDEICSSETLLIVPTPAGVLFTQATAQRWTTESHLVFACGRYEGIDQRVVQDAARRMRVEEVSIGDYVLPGGESAAVVMVEAVLRLLAGVLGNPASHQDDSHSTGLDGLLEGPSYTRPASWRGLDVPEVLLSGDHARIAAWRREVSLQRTRERRPDLSHPD
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLLP_HUMAN
Sequence: MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA
What is the function of this protein?
Appears to be involved in myelination.  Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity).
What are the official names of this protein?
Plasmolipin, Plasma membrane proteolipid.
What is the protein family that this protein belongs to?
Belongs to the MAL family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PCKA_CAMJJ
Sequence: MKKFDNLGLDNIKEIFHNLSYDELNAHEKANNEGLSTDNDTFCVDTGIFTGRSPKDKYFVKQDPSSKYIAWGKINQPITKELFDKLLTKAKQELSGKKIYVQDAFCGASLQSRKAVRFVTEIAWQAHFVKNMFIRPSQEELENFKADFIVYNACKCINEDYKQDGLNSEVFVIFNVEENIAVIGGTWYGGEMKKGIFSMMNYWLPLENKLSMHCSANVGEKDDVALFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDEGVFNFEGGCYAKTINLDPEHEPEIYGAIKRNALLENVVLRADKSVDYADASKTENTRVSYPIEHIENHEPSLKAGHPKNIIFLSADAFGILPPVSKLSKEQAMYYFLSGYTAKVAGTERGITEPQATFSACFGEPFMPLHPTVYARLLGEKIEKHEVNVYLVNTGWSGGSYGVGKRMSIKATRACINAILDGSIAKCEFENFEVFNLAIPKALEGVESTLLNPINTWLDKNAYAETRDKLAHMFVQNFKRYEDVKEGIEFSKFGPKI
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AHP2_ARATH
Sequence: MDALIAQLQRQFRDYTISLYQQGFLDDQFTELKKLQDDGSPDFVSEVLSLFFEDCVKLISNMARALDTTGTVDFSQVGASVHQLKGSSSSVGAKRVKTLCVSFKECCEAKNYEGCVRCLQQVDIEYKALKTKLQDMFNLEKQIIQAGGIVPQVDIN
What is the function of this protein?
Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs).  Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay.
What are the official names of this protein?
Histidine-containing phosphotransfer protein 2.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: RPO1C_THEAC
Sequence: MASLLWRDTSKNIAAILEKLPADYAVDYDVPNNVEDGYITINKKNFTYHVVISGVRKYSPDVEAIVKKKSGLKSIITIEKVEKIEPLSFMEFRVGGKTLEAMGSFEVAERQVTEIKEKYGENLSEDVQKVLDDARAMGFTLPESVAEEIARRRTEWGEKAYKNILKRIGEEIGNELIDPYEAVGIIAAQSIGEPGTQMTMRTFHFAGVREMNVTLGLPRLIEIVDARRIPSTPSMTIYLRPEYETNDEVVMDVVKRLENTSISDVADIITDIGELTVTVRPDPRKTKDRLIEMEDIMNAISKIKGITVMEDSGQIIIKPQQESFKKLYLLQEQIKGLTIKGISGIKRAIARVEGKEHRWVIYTQGSNLKDVLEVDEVDPTRTYTNDIVEIANVLGIEAARNAILNEALRTLQEQGLNVDVRHLMLVADMMTFSGSVRAVGRTGISGRKSSVLARAAFEITTKHLLRAGIMGEVDKLAGVAENIIVGQPITLGTGAVDIIYKGYPKTKK
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_NITEU
Sequence: MIPPKRNKHFFVKIVLALEYDGRGYCGWQKQPGCLSVQSRLESALSGVAGRQIQVVAAGRTDAGVHALCQVVHLETCVRRPLNAWIRGTNALLPGDISILEASEVSDDFHARFSATERTYLYYLLSRPARPGIHHGKIGWVHYPLDLEKMQMAAKLLIGKHDFSAFRSSECQSRTAIRQLTRLNISQHQQLFVFEFCANAFLHHMVRNILGGLVYIGRGKYPPEWMRILLEKRDRTLAAPTFSPDGLYLSGVRYDARWNLPVFNVTRPLDII
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: COX3_RICBR
Sequence: MNNSHPTTKSHLFHIVDPSPWPILTSFALLILVAGGVSFMHSYKFNHYILAFGVISVAYCLYSWWRDVIKEGIIDHSHTEPVRHGLRIGMALFILTEIMFFGVFFASFFKSSLSPVGLLDGVWVIKQGVWPPPNIKVFDPFDIPFINTLILLLSGTTVTWAHYALEERNQKDCVTALGLTIILGIFFTCMQAYEYYHAAFKFTDGIYPSNFYLATGFHGAHVIIGTIFLIVCCFRARRGDFAIKNNGHLGFEFAAWYWHFVDVVWLFLFTFVYIFGS
What are the official names of this protein?
Probable cytochrome c oxidase subunit 3, Cytochrome aa3 subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RHG18_HUMAN
Sequence: MSWLSSSQGVVLTAYHPSGKDQTVGNSHAKAGEEATSSRRYGQYTMNQESTTIKVMEKPPFDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLSNLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFAQQRESKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQALNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHALGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKKDKRAMKKLLKKMAYDREKYEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTYMKDLYQLNPNAEWVIKSKPL
What is the function of this protein?
Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho.  Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595).  Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation.  Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702).  Regulates cell shape, spreading, and migration (PubMed:21865595).
What are the official names of this protein?
Rho GTPase-activating protein 18, MacGAP, Rho-type GTPase-activating protein 18.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STHA_ECOL5
Sequence: MPHSYDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYQNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNARFVDEHTLALDCPDGSVETLTAEKFVIACGSRPYHPTDVDFTHPRIYDSDSILSMHHEPRHVLIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALQNIGLETDSRGQLKVNSMYQTAQPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTTMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU3M_SIGHI
Sequence: MNLFVALFINASLSFILISVAFWLPQLNIYTEKASPYECGFDPLSSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQITKLSAMMITSFILISILALGLIYEWMNKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GRPE_CAMC5
Sequence: MSEEIKEQNVQDAQNENLAPDSVNFDGLSDAAKVAELENKLNELTDKYYRANAEFENIKKRFEKEKTDIASYANEKFARDLLPVIDALEIAANFDPDDDEFAKNVKEGVLITINQFKKCFEKHGMSEIDTSGEFDPNVHNAVLRVDSEDHTSGQIVQVMQKGYIINGRVLRPAMVSVAN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TVP15_SCHPO
Sequence: MDKTKMFSAINLGVGGIFVLSGFIKLFSFSFVNALLALFIIVFGLGTIGLEKEIPPIAIKYGSFMFSFLGRGFFYAFMGTLLFSYSGFTSFLGFLVLLAGIAYCGANYVAGLQDYAPRSMRDNDWDDNVDEV
What is the function of this protein?
Golgi membrane protein involved in vesicular trafficking.
What are the official names of this protein?
Golgi apparatus membrane protein tvp15.
What is the protein family that this protein belongs to?
Belongs to the TVP15 family.
Protein: FETUA_MERUN
Sequence: MKTLVLLLCFTLLWGCQSAPQGTGLGFREVACDDPEVEQVALTAVDYLNQHLLQGFKHILNQIDKVKVWSRRPFGEVYELELDTLETTCHALDPTPLANCSVRQLAQHAVEGDCDFHILKQDGQFSVMHTKCHSNPDSAEDVRKVCPHCALLTPFNSSNVVYAVNAALGAFNEKNNKTYFKLVELARAQTVPFPPSTHVEFVIAATDCAAPKVADPAKCNLLAEKQYSFCKASLFQNLGGEEVTVTCTAFPTQANGVTPASPAPAVEKGIPVALPDAPPASLVVGPMVVPAEHLPHKTHHDLRHAFSPVASVESASGEAFQSPTQAGNAGAAGPAVPLCPGRVRHFKI
What are the official names of this protein?
Alpha-2-HS-glycoprotein, Countertrypin, Fetuin-A.
What is the protein family that this protein belongs to?
Belongs to the fetuin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPTD_XANAC
Sequence: MRRALRLLPLPLSIAICLPAMAADKPLNWGLCPAVDPLPGFDGAPAADPKAAEMRQQLPTDIEGDQLSGTSTTPQYQGNVALKRGDQFLGADNLRMDTETGNYIAEGNVRYQDTSFRMVADRAEGNQDTDTHKVTNIQYQLVERRGNGDAESVDLQGQVGQMHRSTYTTCDPSQPIWRVRAPEIDVDNEEGFGTARNAVLQIGKVPVLYFPWFKFPIDDRRQTGLLFPQFGLSGRNGFDYLQPIYLNLAPNYDATLLPRYMSKRGFMFGTEFRYLYEGGRGEVTGNYLPNDKLRDKDRGSVFYSGYHNVNTHWQARSSISWVSDTRYVEDFTSRLNGMGSASSLQSTVGIYGTGETWTAGLMADRWQLTDYTLDEQALPYNRQPRAYFTWEKPFGIFEAGVYAEAVRFTHDDSYFVQPPSPSAPGETNNRDDNDEYVRTNIRNKEYGSGARLDVKPYISMPLSGAAWFLTPTVAWRYTAYQLDSTLANTAPLTGNRTPSRSLPIASLDAGLYFDRETSLFGTNYLNTLEPRMYYLYVPYRDQDDLPVFDTRPFTFSYGQLFRDTRYTGADRQNDANQLTLAVTSRWLRQDDGREKLSLSAGQILYFSDSLVTINNSNNSAAGSEQTVEQGKSAWVADANYMINDRWSMGATYQWNPNSRKEDLASLRTRYLLNNDGIINLAYRYRRNLTDNSDQLKQADFSFLYPINPSWSAVGRYYYSLLDRKPLEIIGGVQWDSCCLAVRGLVRRFVRNRDGEMDNSIQIEFVLKGLSSFGQNTDRTLRRAILGYYRDDLYLVPPSNTTTNPDDYDPNLIP
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: HSL4_DICDI
Sequence: MSILSSLISISNPMKSSKSSVANGGGSSLSMGSNSIACGSCGSNGGNGRKRLPSDYTNIDSNAGSYTTASGSTYSYSYSYGYYSGSCGCN
What are the official names of this protein?
HssA/B-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: MUKE_ECOL6
Sequence: MPVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRAPEGFFYLRPRSTTLIPRSVLSELDMMVGKILCYLYLSPERLANEGIFTQQELYDELLTLADEAKLLKLVNNRSTGSDVDRQKLQEKVRSSLNRLRRLGMVWFMGHDSSKFRITESVFRFGADVRAGDDPREAQRRLIRDGEAMPIENHLQLNDETEESQPDSGEEE
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Probably acts via its interaction with MukB and MukF.
What are the official names of this protein?
Chromosome partition protein MukE.
What is the protein family that this protein belongs to?
Belongs to the MukE family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: HAKAI_XENLA
Sequence: MDHNDNDLQGTNSMGSLSGLDVRRRIPIKLISKHPNKIKPAPRPQRNMNRIPTKPQPGFDYNEEERYENKGDVFNNQRRFSAHLFWDFKLNLIGEKEDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCALMHEKKADKLCPGTLVEDSTDTFKRMSCNDPVQRIEQCARGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRASKPTARPQPEPIHPPLAPPPAEIPDRFIMPPDKHHLSHMPPKQHILMPPPPMQHVPHEHFSQQHDDIRPSPADISLAPPPPRSVNQDAFRISTRQHSNLITVPIQDDSNSGARETPQAPGPTLHHPEYPGQPVVAHPHHIMPPQQHYAPPPPPPPPISHPMQHPPQAAGTPHMVYSQGPPPPMTTAPPPITPPPGHIIAQIPPYMNHPPPGPPPQHGGPPVNAPPPHHYNPSSMPQFNEDQGTLSPPFTQPGGMSPGMWPAPRGPPPRMQGPPSQAPMPGPHHPDQARYRPYYQ
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates.  Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.
What are the official names of this protein?
E3 ubiquitin-protein ligase Hakai, Casitas B-lineage lymphoma-transforming sequence-like protein 1, c-Cbl-like protein 1, RING-type E3 ubiquitin transferase Hakai.
What is the protein family that this protein belongs to?
Belongs to the Hakai family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm.
Protein: PYRC_EHRCR
Sequence: MYKQSWELLGNGQHADLTVAYINARIIDPESKLDIRGSLLTKGDKIIDFGPDLFANGIPSTIDEVIDCNNNILLPGLIDIHVHFREPGQEHKETINTGSKSAAAGGITTVVCQPNTIPTISSVITAKYIKMRALESAYVNIEFYASITKSDNSLSDMALLKEVGAVGFTDDGMPVMNALTMRQALSYSSMLDTVIAQHAEDLNISNNGCINEGIISYELGLKGIPDISESIIVNRDIALMKNIKNVHYHILHVSSQESLHIIKQAKSQGLKVTCEVTPHHFTLTERDIMTHGSLAKMNPPLRTENDRLSMIEGLKSGIIDCIATDHAPHDINAKELPLDTAAFGIVGLETMLPISLELYHNGTMPLIDLLATLTYKPADIIKVPRGRIKKDYVADLIILDLDHEWVVDISKFASKSKNSPFHNRKVKGKVLRTIVSGKTTYKAEIII
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: SYM_ACTP7
Sequence: MSRKMLVTCALPYANGAIHLGHMLEHIQADIWVRFQRMRGNEIYFVCADDAHGTPIMLNAAKQGITPEQLIEKAKTDHVADFKGFNISFDNYHSTHSEENREITTEMYKKLRANGFIKSRVISQLFDPEKQMFLPDRFVKGTCPKCKAEDQYGDNCEVCASTYSPMDLINPRSAVSGATPIVKESEHFFFDLPSFEGMLKEWTRSGSLQSEIANKMQEWFESGLQQWDISRDAPYFGFPIPDAENKFFYVWLDAPIGYMASFKNLCDRTGLNFDEFWKKDSETELYHFIGKDIVYFHSLFWPAMLDGCELRKPTNVFAHGYVTVDGVKMSKSRGTFIQASTYLKHIDPECLRYYYAAKLNERIEDLDLSLEDFVQRVNSDIVNKLVNLASRNASFIAKRFEGKLADKLEDEALFAEFIAQSEQIAAHYENREFNKAIRLIMDLCDKANKYVDDKAPWVIAKQEGCDAQLQAVCSMGIELFRVLMSYLKPVLPQLAERAEAFLQTELTWDNIQQPLLGQNVAPFKSLFSRLEKKQIDAVIEETKALFAAQNKAEDKKGKQKVENTENTAVEPIAAEITIDDFAKLDLRVAKVISCEAVPESNKLLKFQLDLGDHQRQVLSGIKAAYNNPEELVGRFVIMVANLAPRKMKFGVSEGMILSAGTGGADLFLLSADEGIRPGMQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLD3_BOVIN
Sequence: MKPKLMYQELKVPAEEPASELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTSNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEASAQQGEEVLRQLQTLAPRGVKVRIAVSKPNGPQPQADLQALLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRPYDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDNARSFIYIAVMNYLPIMEFSHPRRFWPAIDDGLRRAAYERGVKVRLLISCWGHSDPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADDAQARIPYARVNHNKYMVTERATYIGTSNWSGSYFTETAGTSLLVTQNGRGGLRSQLEAVFLRDWDSPYSHDLDAAADSVGNACRLL
What is the function of this protein?
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity).  Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity).  May be important in myotube formation.  Plays a role in lysosomal homeostasis.  Involved in the regulation of endosomal protein sorting (By similarity).
What are the official names of this protein?
5'-3' exonuclease PLD3, Choline phosphatase 3, Phosphatidylcholine-hydrolyzing phospholipase D3, Phospholipase D3, PLD 3.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Lysosome lumen. Early endosome membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Note=Localizes to ER-associated vesicles in differentiating myotubes. The soluble form in lysosome arises by proteolytic processing of the membrane-bound form.