PharMolix/UniProtQA huggingface dataset:
Protein: ATPB_TOBAC
Sequence: MRINPTTSGSGVSTLEKKNPGRVVQIIGPVLDVAFPPGKMPNIYNALVVQGRDSVGQPINVACEVQQLLGNNRVRAIAMSATEGLTRGMEVIDTGAPISVPVGGATLGRIFNVLGEPVDNLGPVDTSTTSPIHRSAPAFIQLDTKLSIFETGIEVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEENIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYKELQDIIAILGLDELSEEDRLLVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDGLPEQAFYLVGNIDEATAKAMNLEMESNLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: MURC_DESAL
Sequence: MYRKKYSIHFVGIGGIGMSGIAELLLNLGYQVSGSDIKESDITQRLAKLGGTIYRGHRAENVKGCDVVVVSSAIRQENPETASAREQGIPVIPRAEMLAELMRLKYSVAIAGAHGKTTTTSIVADVLAAGGLDPTVVIGGKLLSIGSNAKLGHGEFIVAEADESDGSFLKMSPSIAVVTNIDREHMDHYKDMDEIKDAFAQFVDKIPFYGLSVLCLDSEPVQDLIPFINKRYVTYGLTTQADLQAGDVTTEGLTSRFTVRHNKKRLGRITLNLPGLHNVYNSLASIAVGLELNVPFENIKAALESLSGVHRRLETKGKVGGIVVMDDYGHHPTEIRTTLQAVNDSYPERRVGVIFQPHRYSRTQSLFEDFARSFYQADYLVVLPIYPAGEKPIPGVDSVSLCKALKAYGHKHVIHAPSKESALQELDKTVREGDVLITLGAGDVYRVGESFLASRS
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_PSEAE
Sequence: MSRVTLSRYLIEQTRSHNTPADLRFLIEVVARACKEISHAVSKGALGGVLGSMGTENVQGEVQKKLDVMSNEILLEANEWAGNLAGMASEEMDHPYQIPGRYPKGAYLLVFDPLDGSSNIDVNVSVGTIFSVLRCPNEYLNQNDTLREEAFLQPGTTQVAAGYAIYGPQTMLMLTLGNGVKGFTLDRELGSFVLTHDNISVPESTAEFAINMSNQRHWEAPVKRYVEELLAGKEGPLGKNYNMRWIASMVADVHRILTRGGVFMYPRDAREPEKPGKLRLMYEANPMSFIIEQAGGAATNGTQRILDIKPENLHQRVAVFLGSKQEVERITGYHAE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAV2_HUMAN
Sequence: MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTYPSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDTQIYTDWANHYLAKSGHKRLIRDLQQDVTDGVLLAQIIQVVANEKIEDINGCPKNRSQMIENIDACLNFLAAKGINIQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQPQKQHLSSPLPPAVSQVAGAPSQCQAGTPQQQVPVTPQAPCQPHQPAPHQQSKAQAEMQSSASSKDSSQSKIIRFTLGQKKISRLPGPTARVSAAGSEAKTRGGSTTANNRRSQSFNNYDKSKPVTSPPPPPSSHEKEPLASSASSHPGMSDNAPASLESGSSSTPTNCSTSSAIPQPGAATKPWRSKSLSVKHSATVSMLSVKPPGPEAPRPTPEAMKPAPNNQKSMLEKLKLFNSKGGSKAGEGPGSRDTSCERLETLPSFEESEELEAASRMLTTVGPASSSPKIALKGIAQRTFSRALTNKKSSLKGNEKEKEKQQREKDKEKSKDLAKRASVTERLDLKEEPKEDPSGAAVPEMPKKSSKIASFIPKGGKLNSAKKEPMAPSHSGIPKPGMKSMPGKSPSAPAPSKEGERSRSGKLSSGLPQQKPQLDGRHSSSSSSLASSEGKGPGGTTLNHSISSQTVSGSVGTTQTTGSNTVSVQLPQPQQQYNHPNTATVAPFLYRSQTDTEGNVTAESSSTGVSVEPSHFTKTGQPALEELTGEDPEARRLRTVKNIADLRQNLEETMSSLRGTQVTHSTLETTFDTNVTTEMSGRSILSLTGRPTPLSWRLGQSSPRLQAGDAPSMGNGYPPRANASRFINTESGRYVYSAPLRRQLASRGSSVCHVDVSDKAGDEMDLEGISMDAPGYMSDGDVLSKNIRTDDITSGYMTDGGLGLYTRRLNRLPDGMAVVRETLQRNTSLGLGDADSWDDSSSVSSGISDTIDNLSTDDINTSSSISSYANTPASSRKNLDVQTDAEKHSQVERNSLWSGDDVKKSDGGSDSGIKMEPGSKWRRNPSDVSDESDKSTSGKKNPVISQTGSWRRGMTAQVGITMPRTKPSAPAGALKTPGTGKTDDAKVSEKGRLSPKASQVKRSPSDAGRSSGDESKKPLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGVTVTSRSATLGKIPKSSALVSRSAGRKSSMDGAQNQDDGYLALSSRTNLQYRSLPRPSKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTDKEKGISSDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATAENMKNSVVISNPHATMTQQGNLDSPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHSAPSNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSSTGLIASSKDDSLTPFVRTNSVKTTLSESPLSSPAASPKFCRSTLPRKQDSDPHLDRNTLPKKGLRYTPTSQLRTQEDAKEWLRSHSAGGLQDTAANSPFSSGSSVTSPSGTRFNFSQLASPTTVTQMSLSNPTMLRTHSLSNADGQYDPYTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEEESWEKSSVDNFVSRLHSSLHFSLPLFHHARYELVHGSSLSLVSSTSSVYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAHLVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINTPELNCKGNGTAQSADLRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNWVNELRSSFKQAFGKKKSPKSASSHSDIEEMTDSSLPSSPKLPHNGSTGSTPLLRNSHSNSLISECMDSEAETVMQLRNELRDKEMKLTDIRLEALSSAHQLDQLREAMNRMQSEIEKLKAENDRLKSESQGSGCSRAPSQVSISASPRQSMGLSQHSLNLTESTSLDMLLDDTGECSARKEGGRHVKIVVSFQEEMKWKEDSRPHLFLIGCIGVSGKTKWDVLDGVVRRLFKEYIIHVDPVSQLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTTISVTVKGLAENSLDSLVFESLIPKPILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFNVDHKSSKELRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIFNGLLNCKYHKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGFLGRFLRRKLMETEISGRVRNMELVKIIDWIPKVWHHLNRFLEAHSSSDVTIGPRLFLSCPIDVDGSRVWFTDLWNYSIIPYLLEAVREGLQLYGRRAPWEDPAKWVMDTYPWAASPQQHEWPPLLQLRPEDVGFDGYSMPREGSTSKQMPPSDAEGDPLMNMLMRLQEAANYSSPQSYDSDSNSNSHHDDILDSSLESTL
What is the function of this protein?
Possesses 3' to 5' helicase activity and exonuclease activity.  Involved in neuronal development, specifically in the development of different sensory organs.
What are the official names of this protein?
Neuron navigator 2, Helicase APC down-regulated 1, Pore membrane and/or filament-interacting-like protein 2, Retinoic acid inducible in neuroblastoma 1, Steerin-2, Unc-53 homolog 2, unc53H2.
What is the protein family that this protein belongs to?
Belongs to the Nav/unc-53 family.
Protein: NOP10_CANGA
Sequence: MHLMYTLDNEGKRVYTLKKMTEEGEITKSAHPARFSPDDKYSRQRVTLKKRYNLLPQ
What is the function of this protein?
Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.  The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs.  The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit NOP10, Nucleolar protein 10, Nucleolar protein family A member 3, snoRNP protein NOP10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: BLMH_RABIT
Sequence: DPQFVLAQNVGTHHDLLDICLRRATVQGAQHVFQHVVPQEGKPVTNQKSSGRCWIFSCLNVMRLPFMKKLNIEEFEFSQSYVFFWDKVERCYFFLNAFVDTAQKKEPEDGRLVQYLLMNPTNDGGQWDMLVNIIEKYGVVPKKCFPESHTTEASRRMNDILNHKMREFCIRLRNMVHSGATKAEISATEDTMMEEIFRVVCICLGNPPETFTWEYRDKDKNYQKIGPITPLEFYRQHVKPLFNMEDKICFVNDPRPQHKYNRLYTVDYLSNMVGGRK
What is the function of this protein?
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
What are the official names of this protein?
Bleomycin hydrolase, BH, BLM hydrolase, BMH.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic granule. Note=Co-localizes with NUDT12 in the cytoplasmic granules.
Protein: BGL26_ARATH
Sequence: MAHLQRTFPTEMSKGRASFPKGFLFGTASSSYQYEGAVNEGARGQSVWDHFSNRFPHRISDSSDGNVAVDFYHRYKEDIKRMKDINMDSFRLSIAWPRVLPYGKRDRGVSEEGIKFYNDVIDELLANEITPLVTIFHWDIPQDLEDEYGGFLSEQIIDDFRDYASLCFERFGDRVSLWCTMNEPWVYSVAGYDTGRKAPGRCSKYVNGASVAGMSGYEAYIVSHNMLLAHAEAVEVFRKCDHIKNGQIGIAHNPLWYEPYDPSDPDDVEGCNRAMDFMLGWHQHPTACGDYPETMKKSVGDRLPSFTPEQSKKLIGSCDYVGINYYSSLFVKSIKHVDPTQPTWRTDQGVDWMKTNIDGKQIAKQGGSEWSFTYPTGLRNILKYVKKTYGNPPILITENGYGEVAEQSQSLYMYNPSIDTERLEYIEGHIHAIHQAIHEDGVRVEGYYVWSLLDNFEWNSGYGVRYGLYYIDYKDGLRRYPKMSALWLKEFLRFDQEDDSSTSKKEEKKESYGKQLLHSVQDSQFVHSIKDSGALPAVLGSLFVVSATVGTSLFFKGANN
What is the function of this protein?
Possesses beta-glucosidase activity toward 4-methyl-umbelliferyl-beta-D-glucoside in vitro.  Possesses myrosinase activity toward indol-3-yl-methylglucosinolate (I3M) and 4-methoxy-indol-3-yl-methylglucosinolate (4MO-I3M) in vivo (PubMed:19095900).  Component of an inducible preinvasion resistance mechanism that prevents penetration of the nonhost fungal species B. graminis and E. pisi (PubMed:16293760).  Involved in indole glucosinolate (IGS) activation during pattern-triggered immunity (PTI).  Functions as myrosinase for the breakdown of flg22-triggered IGS.  Required for both callose deposition and glucosinolate activation during pathogen-triggered resistance (PubMed:19095898).  During fungal attack, required for IGS activation that mediates broad-spectrum antifungal defense (PubMed:19095900).
What are the official names of this protein?
Beta-glucosidase 26, peroxisomal, AtBGLU26, Protein PENETRATION 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: CXP1_PARCG
Sequence: GWPAYPGRNGIRSSVCQKKLGCGWRKLASLPVCKAFCLARKRFWQKCGKNGSSGKGSKICKSVIAHTFEKAGKGLIKLTDMAVATIIKYAGKK
What is the function of this protein?
Cytolysin that shows hemolytic activity (on bovine erythrocytes, HC(50)=5. 75 mg/ml) (By similarity).  This hemolytic activity is completely inhibited by small unilamelar vesicles composed of PC/PG, PC/PI and PC/PS in 1:1 molar ratios (with at least 100 mg/ml concentration) (By similarity).  The recombinant protein does not show hemolytic activity, suggesting that it is not properly folded or that it requires a free N-terminal end for its activity (Probable).
What are the official names of this protein?
Parbolysin P1, Parbolysin 1.
What is the protein family that this protein belongs to?
Belongs to the worm cytolysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: UPP_LACKL
Sequence: MSSEPFKNVYLLPQTNQLLGLYTIIRDKKTKRPDFVFYSDRIIRLLVEEGLNHLPVTPNTVETDTNQSFDGVSFLGKICGVSIVRAGESMEQGLRDCCRSVRIGKILIQRDEETALPKLFYEKLPDDIADRFVFLLDPMLATGGSAIMATEVLIKRGVKPERIFFLNLICSKEGIENYHAKFPTIKIVTGALDKGLDANRYLIPGLGDFGDRYYCI
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UPRTase, Pyrimidine-degrading protein 16, UMP pyrophosphorylase, Uracil catabolism protein 6.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: GSPK_AERHY
Sequence: MPSCRRQGGMALLVVLLILSVMVIIASNMSGRLQLELRRTGNLTAGKQAWWYAMSAEALVSKVLVQDFKDDPNVVNLGQNWARQDAVFPVDDGKLTGRVRDLQSCFNLNSLSVPLKDGISGDDLEKQPYPVKAFRALLKQLEVEDYEAVQLTDAIRDWTDKDTALVSSYGAEDAYYEGLTPPYLTANQWMLSTDELRAVRGVSARLYARLAPYVCALPSDKLLVNINTIKPEQAALLVALYLDKVGLDDAKRVLTSRPQKGWKEKKAMTDQMPAPLSTIPGLDAVLDVKSSYFEARLIAEVGDTRARLESVFVRGKDNKLVMLRRLNGGAE
What is the function of this protein?
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Plays a role in pseudopilus assembly and seems to control its length.  Interacts with the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.
What are the official names of this protein?
Type II secretion system protein K, T2SS protein K, General secretion pathway protein K.
What is the protein family that this protein belongs to?
Belongs to the GSP K family.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: SNAI2_RAT
Sequence: MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLCESYPMPVIPKPEILTSGAYSPITVWTSAVPFHSPLPSGLSPLTGYSSSLGRVSPLPSSDTSSKDHSGSESPISDEEERLQPKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQARKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH
What is the function of this protein?
Transcriptional repressor that modulates both activator-dependent and basal transcription.  Involved in the generation and migration of neural crest cells.  Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells.  Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells.  In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription.  Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes.  Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes.  Represses E-Cadherin/CDH1 transcription via E-box elements.  Involved in osteoblast maturation.  Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts.  Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts.  Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity).
What are the official names of this protein?
Zinc finger protein SNAI2, Neural crest transcription factor Slug, Protein snail homolog 2.
What is the protein family that this protein belongs to?
Belongs to the snail C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions (By similarity).
Protein: HOP_PIG
Sequence: MSAEPANGPTEDQVEILEYNFNKVNRHPDPTTLCLIAAEAGLSEEETQKWFKQRLAQWRRSEGLPSECRSVTD
What is the function of this protein?
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development.  Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development.  Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF.  Overexpression causes cardiac hypertrophy.  Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
What are the official names of this protein?
Homeodomain-only protein, Odd homeobox protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: GPH_CERS5
Sequence: MPGVVFDLDGTLVHSAPDIHAAVNRALAEEGAEPFSLAEITGFIGNGVPVLIKRVLAARGETPDGHRHAEMQDRFMKHYEADPTALTSVYPGAEAALRHLHSEGWRIALCTNKPYAASRQILSNFGILDLFDAIVGGDCLPQRKPDPAPLRAAAAALTEEVVLYVGDSEVDAATAEAAGLRFALFTEGYRHAPVHDLPHHGLFSHHDELPDLLRHLLA
What is the function of this protein?
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.  Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: RS11_LISMO
Sequence: MARKTNTRKRRVKKNIESGIAHIRSTFNNTIVMITDTHGNALAWSSAGSLGFKGSRKSTPFAAQMAAESAAKSAQEHGLKTLEVTVKGPGSGREAAIRALQAAGLEVTAIKDVTPVPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: XERD_STAAU
Sequence: METIIEEYLRFIQIEKGLSSNTIGAYRRDLKKYQDYMTEHHISHIDFIDRQLIQECLGHLIDQGQSAKSIARFISTIRSFHQFAIREKYAAKDPTVLLDSPKYDKKLPDVLNVDEVLALLETPDLNKINGYRDRTMLELLYATGMRVSELIHLELENVNLIMGFVRVFGKGDKERIVPLGDAVIEYLTTYIETIRPQLLKKTVTEVLFLNMHGKPLSRQAIWKMIKQNGVKANIKKTLTPHTLRHSFATHLLENGADLRAVQEMLGHSDISTTQLYTHVSKSQIRKMYNQFHPRA
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerD.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_CORDI
Sequence: MKKVALLDYGSGNLRSAQRALERVGAEVEVTNDPDVVLAADGLLVPGVGAFDACMKGLKAVQGDRMIGQRLAGGRPVMGICVGMQIMFDSGNEHGISAAGCGQWPGNVEKLEARVLPHMGWNTVEAAQDSQLFAGLDADTRFYFVHSYGVRWWEFEGDGLTRAPLVTWAQHESDRFVAAVENGALMATQFHPEKSGDAGAQLLRNWIDLL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_CALBD
Sequence: MKLYNTLTMTKEEFEPLEEGKVKMYVCGPTVYDFIHIGNARPLIVFDTLRRYFEYKGYEVIYIQNFTDVEDKMINRANKEGITVFELAERFIQEYYKDADRLNVKRATKNPRATEEIEDMIALIQRLIDKGYAYVVDGDVYFRTRKFAEYGKLSHKNIEELMAGARVDPNEKKEDPLDFALWKAKKEGEPAWSSPWGEGRPGWHIECSVMAMKYLGQTIDIHAGGQDLIFPHHENEIAQSEAATGKPFARFWLHNGYVNINNEKMSKSLGNFFTVREIIEKYHPEALRLFMLQAHYRKPLNFSIDLIEQAEVALKRIYTCYENLEFLIQNAASSSENDDKLKAAIEELKAKFIDAMEDDLNTAEATGYLFEMVREINTYANSCSKETLTFAKDTLKELCSILGILEQYSAKEEAIPQQILELVEKRNQARKAKNFAEADRIRDELKSLGYIVLDTPQGTKIERIK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_RIPO1
Sequence: MPKLKTRKAAAKRFRVTGSGKKIFRRKAFKNHLLQHKSSERKFRRLSGLSLVSEQDEANVRLMLPYL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: PEX19_PONAB
Sequence: MAAAEEDYGVGAEADRELEELLESALDDFDKAKPSPAPPSTTTAPDASGPQKRSPGDTAKDSLFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDMTSQQEFTSCLKETLSGLAKNATDLQNSGMSEEELTKAMEGLGMDEGDGEGNILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHRESLPPEQFEKYQEQHSVMCKICEQFEAETPTDSETTQKARFEMVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDALNLSGPPGASGEQCLIM
What is the function of this protein?
Necessary for early peroxisomal biogenesis.  Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs).  Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3.  Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
What are the official names of this protein?
Peroxisomal biogenesis factor 19, Peroxin-19, Peroxisomal farnesylated protein.
What is the protein family that this protein belongs to?
Belongs to the peroxin-19 family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Lipid-anchor; Cytoplasmic side. Note=Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes.
Protein: TSH2_HUMAN
Sequence: MPRRKQQAPKRAAGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPGSHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLRPTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFADSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQSLSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGPLKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSVLNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHALSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQERMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEISRVSSAQRSPETIAAEEDTDSKFKCKLCCRTFVSKHAVKLHLSKTHSKSPEHHSQFVTDVDEE
What is the function of this protein?
Probable transcriptional regulator involved in developmental processes.  May act as a transcriptional repressor (Potential).
What are the official names of this protein?
Teashirt homolog 2, Ovarian cancer-related protein 10-2, OVC10-2, Zinc finger protein 218.
What is the protein family that this protein belongs to?
Belongs to the teashirt C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYS_DESAP
Sequence: MLDLKFIRKHPEAVRMALEKRGAEFDLDRLLDLDDEWRQKLFTVERLKNRRNAVSEEIARLKKAGEPAEELIAEMRNVSQQIRELDGEIRQVEENLQALLLQVPNIPHPLVPFGRADTDNEEVRRWGEPPAFGFEPRPHWELGEELNILDFARGGKVSGARFSFCRGAGARLERALICFMLDLHVDRHGYTELFPPFLVNAQSMTGTGQLPKFAADMYKVENEDYYLVPTAEVPVTNYLRDEILDGDTLPRKYAAYSACFRAEAGAAGRDTRGLIRQHQFNKVELVKFTRPEDSEDELEKLVRDAEEVLRLLRLPYRVVLLCTGDLGFSSSRTYDLEVWMPGQGVYREISSCSNFTDFQARRANIRYRAHPRAKADFVHTLNGSGLAVGRTLAAVLENFQQADGTVTVPEVLRPYMGGMERITRK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA_BURCH
Sequence: MNAPHMNDTAADAATLDDAAAPAGRPALTRREQKEAYENNKLFKRIVRQVGQAIGDYNMIEQGDKVMVCLSGGKDSYAMLDVLLRLRERAPIDFDIVAVNLDQKQPGFPEHVLPEYLKQVGVPFHIENQDTYSIVKRLVPEGKTTCSLCSRLRRGILYRVAGELGATKIALGHHRDDIVQTLLLNMFYGGKLKGMPPKLQSDDGKNIVIRPLAYVKETDLEKYAELREFPIIPCNLCGSQPNLKRAEMKALIREWDKRFPGRVDNMFNALAKVVPSHLMDTTLYPFQSLRATGEADPQGDIAFDEEPCASGDDAAAPGAAQPISIVQFDDL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.