PharMolix/UniProtQA huggingface dataset:
Protein: M2_I49A1
Sequence: MSLLTEVETPTRNGWECRCSDSSDPLVIAASIIGILHLILWILDRLFFKCIYRRIKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDSHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: RL2_SHIF8
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PYRB_SULDN
Sequence: MKHLIRTDDFTTQEIESILADAELFSDGRFDRILRDKIIITLFFENSTRTRSSFEIAAKRLGAEIVHLDVANSSTKKGETLVDTAMNLDAMGPHAIIVRHQNSGVAKILSNHTKASIINAGDGAHAHPTQALLDLFTLKKHFKNLEGKKIAIVGDIKNSRVANSNIELLSRFKMEVILVAPPQFLPQSDLRTTHYLEDIIDEVDAIMSLRTQTERHSSQTYASLKDYASDFCITSEVVGDRDIIILHPGPVHRNIDICDALLADKRCKVLEQVANGVAIRMAVLKKLIYDV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: SLX1_YARLI
Sequence: MTHQYPPFYGVYLLQSTKKPLSCYVGSTPNPFRRIRQHNGDLKAGGAWRTKRAHLRPWSMVLIVNGFPSKISALKFEHALQHPNMTRLITTKDIKRKVPQKARALGTHLAFIRLLVRCSYFRRMHLRITFFRSHAHEAWEKNDYDVGSLPPQFQVETDYPSDEAEAPPSTVGSGELDINNRSIEEYLQKCRDAVSNDKQLTCYLSEKTLNISEGNVALCHNCDGAFDVAELAERFLNEEIPEELPFTTPSRHIIPIGGDCPSCLARMEWSNVIKGVLAMRPVLEDNKE
What is the function of this protein?
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EXOX_RHILP
Sequence: MHQRCFGLRASLSIFKAFAVTLAASVFLQVVYFLSLLFMSFRPTRESDRSIHSGTRQADQPQKRDRDKTEQSNVPKLDPRRKRRTP
What is the function of this protein?
Inhibition of exopolysaccharide synthesis (EPS) and nodulation ability (NOD).
What are the official names of this protein?
Exopolysaccharide production repressor protein, Polysaccharide inhibition protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: PSBI_CERDE
Sequence: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGREE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: LACXP_LACLL
Sequence: MTIELKNEYLTVQFKTLGGQLTSIKDKDGLEYLWQADPEYWNGQAPILFPICGSLRNDWAIYRPQERPFFTGLIRRHGFVRKEEFTLEEVNENSVTFSIKPNAEMLDNYLYQFELRVVYTLNGKSIRTEFQVTNLETEKTMPYFIGAHPAFNCPLVEGEKYEDYSLEFSEVESCSIPKSFPETGLLDLQDRTPFLENQKSLDLDYSLFSHDAITLDRLKSRSVTLRSRKSGKGLRVDFDDFPNLILWSTTNKSPFIALEPWSGLSTSLEEGNILEDKPQVTKVLPLDTSKKSYDITILN
What are the official names of this protein?
Protein LacX, plasmid.
Protein: SYM_SHEB8
Sequence: MATSQRKILVTSALPYANGPIHLGHMLEYIQTDIWSRYQKLRGHECHYICADDAHGTPIMLKAQQLGIAPEDMIAQVNKEHQQDFADFNVAFDNYHSTHSEENRLMASDIYLKLRDNGYIKSKSISQLFDPEKSMFLPDRFVKGTCPKCKSPDQYGDNCDSCGATYSPTELINPKSAVSGATPVMKDTEHFFFDLPAFEGMLKEWTRSGALQVEMANKLDEWFEQGLQQWDITRDAPYFGFEIPDAPGKYFYVWLDAPIGYMGSFKNLCAKRPELSFDEFWGKDSTAEVYHFIGKDIVYFHSLFWPAMLHGSGYRQPNSVYAHGYVTVNGAKMSKSKGTFIKARTYLDHLDPEYLRYYYAAKLSSRIDDLDLNLEDFAQRVNSDLVGKLVNLASRTAGFITKRFNGKLAKINDTTLTEAFLAKQDVIADFYESREYGKAMREIMALADIANGFVADAAPWQMVKHDDQQEAAHQVCSNALNLFRILVTYLKPVLPRLAQDVEAFFQLPLTWDALSQDLAGHEIAPFKAMMQRVELDKVNAMVADSKDNLQVTADAPKTAAPEKTAEASSVSSEPLVDDPISETINFDDFAKIDLRIARIIKAEHVADADKLLKLQLDIGGETRQVFAGIKSAYSPEDLEGKLTVMVANLAPRKMRFGMSEGMVLAAGPGGSDLWILEPHEGAQPGMRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_YARLI
Sequence: MARGPKKHLKRLAAPSHWMLDKLSGTYAPRSSAGPHKLRESLPLVIFLRNRLKYALNGREVNAILMQRLVKVDGKVRTDSTFPAGFMDVIQLEKTGENFRLVYDVKGRFAVHRITDEEAAYKLGKVKRVQVGKKGIPYLVTHDGRTIRYPDPLIKVNDTVKIDLATGKITSFVKFENGNIVMTTGGRNMGRVGTITHRERHEGGFDIVHIKDALDNQFVTRLTNVFVIGEGNKSLISLPKGKGIKLSIAEERDARRAKQE
What are the official names of this protein?
40S ribosomal protein S4, S7.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: MRAY_BEUC1
Sequence: MIAILVSGAVGLLVSLFGTPLFIRFLVKRQYGQFIRQDGPTAHFTKRGTPTMGGVVIIAATVLGYTVANISAQRMPQVSGLLLLFLMIGLGVIGFLDDFIKISRQRSLGLNARWKIIGQGVIGVTFSVLALQFPNEQFRTPASTQVSFIRDTGIDLAFAGAAVGLVLFVIWANFLITAWSNAVNLTDGLDGLATGVSVFVFSAYVVVTMWQSNQSCQVLSQVGPSCYETRDPRDLAIVTAAIVGACAGFLWWNASPAKIFMGDTGALALGGALAGLSILTRTEFLAVIIGGLFVVIVLSDVIQIGFFKMTRRRVFKMAPLHHHFELSGWNEVTIVIRFWLIAALFVALGVGIFYAEWVVG
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSO2_SCHPO
Sequence: MSKRKSSSILDFFKKSNNGKNMWGNEAVSVEKTDSTTKPSTVKNAISSSQIKNEKFSQEVLLQFNDPSFTSEVGESPQWQSFGDANILEPLKNELVKNEESTMSELLLCPICGITLESLTVDANIHVNDCLDGRTTEAVSKKLKKDSVVKADPSNSSTFPISDSCKQALLPLPGKQINVRSVVPFYKLMPYNIPFAVDAFAYGAIDGVEAYFLSHFHSDHYGGLTPKWKHGPIYCSEVTGNLLINVMHVDEQYVKRLKLNQPYNIMGITVYVLDANHCPGSAMFVFETLQSNQTRRVLHCGDFRASKDHVMHPVLREKTIHKVYLDTTYLNPKYTFPPQADVVQACADKAISIKKSTDSRLLVVVSTYSIGKEKVAVAIAKSLSSRIYVVPRKMHIIKQLENQDLIDLLTDDPTQASVHMVTMMGIHPNSLLDYLEQYNSSFDKIIGYKVTGWTFQPLENRAQLSSSLDSIISRPPKFVEYDLRAIRGSTDKVAAFVAPYSEHSSFYDLTMFCLSMNIGHIIPTVNVGSQRSREKMNVWLDRWAWRRKKQGLLSLENVDW
What is the function of this protein?
Required for DNA interstrand cross-link repair.  This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs).  This protein may have 5' exonuclease activity on single-stranded and double-stranded DNA, which could be necessary for the processing of DNA double strand breaks prior to religation.
What are the official names of this protein?
DNA cross-link repair protein pso2/snm1.
What is the protein family that this protein belongs to?
Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IKBP1_MOUSE
Sequence: MSLQPAPASRVFMELVPWADRGRENHPISAAEAQPIGRRPHVAEAHPGAREVHVSGAAEVSASPDRALVTVRVSSTKEVSAEAKKSVCRRLDYITQSLQQQGFQAENVTVTKNIRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPEFYHTPGSVENLRRQACLVAVENAWRKAQEVCDLVGQTLGKPLLIKEEETKDWEGQTDDHQLSRLPGTLTVQQKIKSATIHAASKVFITFEVKGKEKKKKHL
What is the function of this protein?
Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival.  Acts by enhancing RELA transcriptional activity.
What are the official names of this protein?
Interleukin-1 receptor-associated kinase 1-binding protein 1, IRAK1-binding protein 1, ActA-binding protein 70, PLK-interacting protein, Signaling molecule that associates with the mouse pelle-like kinase, SIMPL.
What is the protein family that this protein belongs to?
Belongs to the IRAK1BP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NSRR_ECO27
Sequence: MQLTSFTDYGLRALIYMASLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGYVTAVRGKNGGIRLGKPASAIRIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLTELDNYTLADLVEENQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: UPP_FRATW
Sequence: MKVVEISHPMVKHKLGLMRAASISTQEFRRLTKEITSLLTYEVTAGFELEKTEILGWQGENIEIDQIKGKKLTVVPILRAGLGMMDGVFEHVPAAKVSMVGMYRDEKTAKPVAYFAKLCDKLDERVALIVDPMLATGGSMIATVSLLKKAGSKDIKIITLVSAPEGIDALAKAHPDVELYTASIDSHLNDKKYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: FOLD_LISMH
Sequence: MGEIIDGKKLAKEIQEKVTREVAELVKEGKKPGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLSVVEELNEDKTIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRAVVIGRSNIVGKPVAQLLLNENATVTIAHSRTKDLPQVAKEADILVVATGLAKFVKKDYIKPGAIVIDVGMDRDENNKLCGDVDFDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAKRIWKMN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: M140_ARATH
Sequence: MNQLDQYSQPMQHLILLWFWLLDLSPPPSFHLSVKSVDLSLFSLSPLFLLLSISSLIFSRVNKFGIRRVGYAMAPKPDPTVLPDLQEKKAILGTQIEMITQAMTTLESRVTDLQQESNDHRTWVREALDKLLKRDLGDENRPKPTTNKMIATGEQHKGEVSTSLFHD
What are the official names of this protein?
Uncharacterized mitochondrial protein AtMg00140, ORF167.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: ERPA2_METCA
Sequence: MTSELGIFYRSDFDRAWCDMSAETIKFTDSAAQRVSELLAEEGDQNLKLRVYVTGGGCSGFQYGFTFDEVVNEDDTVVEKNGVSVLVDPMSLQYLQGAEIDYTENVSGSQFVIRNPNATTTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA 2.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: FETP_PSYA2
Sequence: MTATFNPQANTVFCRKYQQDLPKMPHPPFPNKKGQELQETVSEKAWKEWLEQQTMLINENHLSMLDPKAKQFLTEQRDKFLDNEDYERAQGWTPES
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: RL16_LAWIP
Sequence: MLAPKKVKFRKWQKGRLRGPALRGISIAYGDIALKSTEHGKLTSQQIEAARIAMMRHIKRGGKVWIRVFPDHPITAKPLETRQGSGKGSPVGWCAPVKPGRILYEIKGVNIDLAREALIRAAHKLPVKTVIVLKERL
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: COAA_BRASB
Sequence: MDMRTTEQQYNPYRVFTRQQWAELRNDTPMTLEPGEFSKLRSMHDRLDLKEVEDIYLPLSRLLSMYVDAAQRLYYAQRQFLGIRDRKMPYIIGVAGSVSVGKSTTARVLQALLARWSPRPKVDLITTDGFLYPNAVLERQGLMQKKGFPESYDLPRLLAFLSDIKAGRHTVRAPVYSHLTYDIVPNQWVEIDQPDILIVEGVNVLQTGPLPRDGKAVPVVSDFFDFSVYIDADEAVLRKWYVKRFLSLRDTAFHDPRSYFNRYALLSDEEAIATAIAIWERTNLANLEDNILPTRPRATLILKKGADHEVETVALRRL
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRL6_ARATH
Sequence: MGKDFKSLVTRCIYVGKMNDNAKKLKIATEELKDLGNNVMKRVKLCEEQQQMKRLDKVQTWLRQADTVIKEAEEYFLMSSSSSSSGLISSSHKMEKKICKKLKEVQEIKSRGMFEVVAESTGGIGGGAGGGLTIKDSDEQTIGLEAVSGLVWRCLTMENTGIIGLYGVEGVGKTTVLTQVNNRLLQQKANGFDFVLWVFVSKNLNLQKIQDTIREKIGFLDRTWTSKSEEEKAAKIFEILSKRRFALFLDDVWEKVDLVKAGVPPPDAQNRSKIVFTTCSEEVCKEMSAQTKIKVEKLAWERAWDLFKKNVGEDTIKSHPDIAKVAQEVAARCDGLPLALVTIGRAMASKKTPQEWRDALYILSNSPPNFSGQIS
What is the function of this protein?
Possible disease resistance protein.
What are the official names of this protein?
Probable disease resistance protein At1g52660.
Protein: PGLR3_ARATH
Sequence: MKKKTWFLNFSLFFLQIFTSSNALDVTQFGAVGDGVTDDSQAFLKAWEAVCSGTGDGQFVVPAGMTFMLQPLKFQGSCKSTPVFVQMLGKLVAPSKGNWKGDKDQWILFTDIEGLVIEGDGEINGQGSSWWEHKGSRPTALKFRSCNNLRLSGLTHLDSPMAHIHISECNYVTISSLRINAPESSPNTDGIDVGASSNVVIQDCIIATGDDCIAINSGTSNIHISGIDCGPGHGISIGSLGKDGETATVENVCVQNCNFRGTMNGARIKTWQGGSGYARMITFNGITLDNVENPIIIDQFYNGGDSDNAKDRKSSAVEVSKVVFSNFIGTSKSEYGVDFRCSERVPCTEIFLRDMKIETASSGSGQVAQGQCLNVRGASTIAVPGLECLELSTDMFSSAQLLEQTCMSAQSVQPRTTTQPMQDPIWVFQSRGKQLRVYNIAILVSFISLVTYILAR
What are the official names of this protein?
Probable polygalacturonase At3g15720, PG, Pectinase At3g15720.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: Y1996_METMA
Sequence: MNQNRGSTIIEIRDLWYTYPGRAETTLKGIDLKIKEGEFVLLTGPTGCGKSTLLKTLNGIIPHESEGIFSGSIKISGIETVDSGQMELSKKAGLVFQSPDDQIFSTTVEDEVAFGPENLCMEREEIDKKVDDALKMVGMSGHRLDSTNSLSGGQKQRVCIASMLAMMPEILAMDEPVSQMDPAGTQEILNTVRELNRKQNITILLVEHRIHEIAPFADRVVIMDSGKIILDQPASKAFENLEVFHRLGLRVPEPVELCHTLGIKASPFSAEETFPLLNTGNFKEKIGDYPASPGRKEKTSSPGWSSENNEPLVSVRDLWSGYDKSRMVLKGINLEIHRGERVAVMGTNGSGKSTLLLNLAAMLRPYKGNVKIFGEDTKTKNPYSFAGRIGFVFQNPDLMLFCDSTEEEAKFGPARLKLDNIEERAKISLEAMSILNLRKDLPQSLSRGQRLRTAVASILSIDPILVLLDEPTTGQDRVNIEQMMDYFKTRGSTLVFCTHDIEIAMLYATRILVMNEGQIIADGRGRDVIKDIDILRKASLTQPPVVEIASYLGIDAFSITELVDGLIHRNPEIRIAEGIKC
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein MM_1996.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CCNY_CAEEL
Sequence: MGNSSCCLRTRSSSGEDKSYNNDGQYIRTNQVEFQYVNQVFPRDETSTNFLPHISEREVTEGYEEDPSTNPTARPTFMERSKSEMKLKDNRRSCYMLDALAAGGHHPGILPRSLRKSSSCSTIYIDDSTVSQPHLKNTIKCISLAIYYHISNRKNRGHERLMEIFEERLHPIFRDPIPPEQMTRDPDHRNIYRFVRNLFSSAQLTAECAIITLVYIERLLNYAEMDLCPSNWRRVVLGSIMLASKVWDDQAVWNVDYCQILRDTNVDDMNELERRFLECLDFNIEVPSSVYAKYYFDLRTLALANDLQLPIQPLYKERAQRLEALSRVFEDKIQSSSLPKRARSAEHLVFEHPAVLS
What is the function of this protein?
In association with pct-1, regulates the trafficking of synaptic vesicle precursors in DA motor neurons by promoting anterograde trafficking to the axon and preventing dynein-dependent trafficking to the dendrite.  May also regulate synaptic vesicle trafficking in DD motor neurons and in RIA interneurons (PubMed:20510931).  Involved in synapse formation during DD motor neuron remodeling by disassembling ventral presynaptic structures (PubMed:21609829).  May activate cdk-5 (PubMed:20510931).
What are the official names of this protein?
Cyclin-Y.
What is the protein family that this protein belongs to?
Belongs to the cyclin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, dendrite. Cell projection, axon. Note=Enriched in the dendrite and the proximal axon of the DA motor neuron.
Protein: PLPHP_SCHPO
Sequence: MSTIHSCLDLIRSQIQQSANGRNVLLVAVSKFHPVETLMEAYNAGQRHFGENYMQEFLKKVELMPDDVQWHFIGSLQSSKCKKIASVKNLYSIETIDTEKKARLVNSAREALQLPLNVYIQVNTSGEENKGGVTPSKVLELCKQVQDMKYLRLKGLMTIGSISNSQLSDHNPDFQVLSDLRESLQNELGIPLQLSMGMSSDYLLAIKYGSDSVRVGSSIFGSRPTEKPSDVHISASK
What is the function of this protein?
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
What are the official names of this protein?
Pyridoxal phosphate homeostasis protein, PLP homeostasis protein.
What is the protein family that this protein belongs to?
Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: IXTPA_LEGPL
Sequence: MKEIILATSNPGKIKELEQLLAPTLCIPQADLGISDAEETGLSFIENAILKARHASSLANKPALADDSGLVVPSLNGEPGIYSARYAGIKANDENNIQQLLSKMADLSQEQRQAYFFCAIALMQHAKDPTPLIATGVFHGVISVKPSGTNGFGYDPVFYLNEYQCTAAELPAKIKNRISHRAKALNQLRALLPD
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: NUOC_JANSC
Sequence: MSDALKELAEYLSEKRSDDVVSTDVNAMGELSVTVAPAQMVGFIEFLKTDRTCRFSTLIDITAVDYPSRDRRFDVVYHFLSMYQNHRVRVRAAIREEDTLPSISGVHPGAGWYEREIYDMFGILFTGHADLRRLLTDYGFRGHPLRKDFPTTGYTEVRYDEELKRVVYEPVSLVQEYRQFDFMSPWEGAQYVLPGDEKADDKAGETA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DNAK_FRAT1
Sequence: MGKIIGIDLGTTNSCLAIMDGKTAKVIENAEGHRTTPSVVAYTDSGEILVGQAAKRQAVTNPDNTFFAIKRLIGRKYDDKAVQEDIKKKVPYAVIKADNGDAWVATKEGKKMAPPQVSAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGKIAGLEVKRIINEPTAAALAYGVDSKKGEQTVAVYDLGGGTFDISIIEIADVDGDNQIEVLSTNGDTFLGGEDFDLALMNYLIDEFKKEQGIDLHNDKLALQRVREAAEKAKVELSSAQQTDVNLPYITADATGPKHLNIKVTRAKFESLVSDLVMRSLEPCKKALEDAGLSKSDITEVLLVGGQTRMPLVQEKVKEFFGKEPRKDVNPDEAVAVGAAIQGGVLAGDVKDILLLDVTPLSLGIETMGGVMTKLIERNTTIPTKKSQVFSTAEDNQPAVTIHVLQGEREMASANKSLGRFDLADIPPAPRGMPQIEVTFDIDANGILNVSAKDKATGKEQNIVIKSSSGLSEEDIEKMVQDAEANAEADKKFHDLVTARNTADNLIHSSRKAIQELGDKVTAAEKEKIEEACKELEAATKGDDKQAIESKTKALEEAFAPIAQKAYAEQAQAAVAQGGAKAEEPKKEEDVVDADFEDVEDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RBFA_BRUC2
Sequence: MARSHDTKGSGGLSQRQLRVGEQVRHALAQVLQRGEIRDDLIERTVISVSEVRMSPDLKIATCFITPLGSADPQAVIKALASHAKFIRGRVAPSLAQMKYMPEFRFRPDTSFDNFSKIDALLRSPEVARDLSHDDDEDGGADEAPRNGDE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMTL3_BOTBR
Sequence: MVSELVSMYVPPIVEAAKAVTPWQAAAGVTAAIFIGSYLWHSASLRKQRRTGTADGGLFSLTAGGIKKQDVTKLVDSFSQAYKTEDDGQLTCHHITREQSVEMVNTFYDLITDLYEWAWDTSFHFSCRPRWANFAQAQVLHEWRIANLANIQPGMKVLDVGTGVGNPGRTIASLSGAQVTGVTINAYQVKRALHHTRKAKLEDFYKPVQADFTDTPFEDDTFDAAFAIEATCHAPKLEQVYKEVYRVLKPGAYFALYDGVTKPNFDPKNERHVQLMNATVIGNGCPDMRTWKECEEIGKEVGFKLHMSYDAGEASRVLHPWWEKLDNFINTGFAWYGPASIKLLSKIGFLPRDFTKFIDIAAASVFSVKEAGELGIFTPMYVFVWQKPEKTA
What is the function of this protein?
Unable to convert squalene, botryococcene, cycloartenol, zymosterol or lanosterol to mono-, di-, tri- or tetramethylated derivatives.
What are the official names of this protein?
Sterol methyltransferase-like 3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein.
Protein: RS2_SHEFN
Sequence: MTTVSMRDMLQAGVHFGHQTRYWNPKMKPFIFGARNGVHIINLEHTVPMFNEALAFISNIASKKGKVLFVGTKRAAGEAIKASALSCDQYYVDHRWLGGMLTNWKTVRQSIKRLKELESQSVDGTFDKLTKKEALMRSRELDKLEKSLGGIKNMGGLPDVLFVIGADHEHIAIKEANNLGIPVVAVVDTNSAPDGVNYIVPGNDDAMRAIRLYTSSVAAAANAGRGQDLAVQAEQDGFVEAV
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.