PharMolix/UniProtQA huggingface dataset:
Protein: LPXB_COXBU
Sequence: MSNKSVLLIAGEPSGDLLGAHLAQSLKSLEPNLKLAGMGGKRMREAGVEVFINADKLAVVGLLEILRQFRDIRHAMQTLKRYFKKTPPDLVVFIDYPGFNLHMAKQAKKAGIKVLYYVSPQIWAWRYGRIKKIKKYVDHMAVLFDFEEKLYQKENVPVSFVGHPLANAPTPSLSRNEICKQFNLDPDKPIVALFPGSREQEINKLLPMMVQAGKLIQTQIPTVQFILPLALNLALDKIRPFLSPEIKVIQNDISYVLAIAHAAVAASGTVTLEIALQQVPLVIIYKVAPLTFWLGKKLIRLSFIGLCNLVSPEPVAVELLQQDATPQAIADEVFQLLNNHNYRQSIIGKLGHLRPQLDRGNAAQNVAKVVHNLIFS
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: RHAT_YERPY
Sequence: MNNAIILGIIWHLVGAASAACFYAPFKQVKKWSWETMWSIGGLVSWLILPWTVSYLLLPDFWQYYGSFSIATLLPVFLFGAMWGIGNINYGLTMRYLGMSMGIGIAIGITLIIGTLMTPILQGRFDVLLGTPGGRMTLLGVFVALIGVAIVSYAGLLKERAMGIQAEEFNLKKGLILAVMCGIFSAGMSFAMDAAKPMHEAASALGINSLYVALPSYVIIMGGGAIINLSYCFIRLATLKNLSVKADFSVAKPLLITNILFSALAGLMWYLQFFFYAWGHAKIPQQYDYMSWMLHMSFYVLCGGIVGLLLKEWKCSTKKPVAVLCIGCLVIILAANIVGLGMAA
What is the function of this protein?
Uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).
What are the official names of this protein?
L-rhamnose-proton symporter, L-rhamnose-H(+) transport protein.
What is the protein family that this protein belongs to?
Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GPAA1_HUMAN
Sequence: MGLLSDPVRRRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTMVEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFSRKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQAVGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTGMQSSPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASGRPHGSHGLFLRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLYLLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEAGMGLEEPGGAPGPSVPLPPSQGVGLASLVAPLLISQAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHNTHRVVSTQAPDRGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPHGPRTLYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQGVLEHHTYGALLFPLLSLGLYPCWLLFWNVLFWK
What is the function of this protein?
Essential for GPI-anchoring of precursor proteins but not for GPI synthesis.  Acts before or during formation of the carbonyl intermediate.
What are the official names of this protein?
Glycosylphosphatidylinositol anchor attachment 1 protein, GPI anchor attachment protein 1, GAA1 protein homolog, hGAA1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: COBS_SULIM
Sequence: MRLKGVLALFSFFTAIPIKSNASLEEIAEYSYISPLIIGISLALIESAVYVLLYRILEALAGIVLLGVVELLRGFNHLDGLLDLGDALMIKGDRERKIKALKDVEIGSGGIGLLLVYLSIQIVALLKLGFSFYTIFYLISSNVLSMTIGLYILSTISPIPESNLGKIFHNKLKGKSTVLLFELIPFISLYNIIVFLVFYMIMHKICRSLGGSSGDIAGASITLSFPLFLLTNEITNLNYSLLSILCYLFLYLH
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TAL1_KLULA
Sequence: MSEPSAKKQKFANSLEALKATGTTVVADTGDFESIAKFTPQDATTNPSLILAAAKQQAYAKLIDSAVQYGKKQGQNIDEQVEIAVDKLLVEFGTAILKVVPGRVSTEVDARLSFDKDATVKKALEIIKLYEAEGISKDRVLIKIASTWEGIQAAQELEKEHDIHVNLTLLFSFAQAVAAAEANVTLISPFVGRILDWYKASTGETYTAETDPGVISVKSIYNYYKKHGYNTIVMGASFRNVGEIKALAGVDFLTISPKLLDELLSSDEPVAKILDPESAKAEGSERVSFINDEPKFRFELNEDAMATEKLSEGIRKFSADIVTLFDLIKAKIQA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
Protein: FTSB_ECO81
Sequence: MGKLTLLLLAILVWLQYSLWFGKNGIHDYTRVNNDVAAQQATNAKLKARNDQLFAEIDDLNGGQEALEERARNELSMTRPGETFYRLVPDASKRAQSAGQNNR
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: LCL2_ARTGP
Sequence: MASILRTALLGLLLFTTAQAQFQFFEQMFGGGQQHQESSGQGGNVPSDSAWYQNTYNGAQCSNYLCPGTLACVAVPHHCPCAHPKVEEKFELGEGSAICASKGGFKAGETARKIELARKGLL
What is the function of this protein?
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
What are the official names of this protein?
Long chronological lifespan protein 2.
What is the protein family that this protein belongs to?
Belongs to the LCL2 family.
Protein: Y1979_METAC
Sequence: MEVNKVRIHDLPEEDRPRERLIRSGPESLSNAELLGIVLRTGSKEENVISLCSRILAEYNIKQLSLANVSRLTQVHGVGKAKAAQIAAVFELARRLETFVEEPKRKICSPKDVYALMYPRMREQKKEKFITLYLDTKNQILKEEVVSIGSLNASIVHPREVFKSALLESSASVIMVHNHPSGDPSPSREDIMVTEKLVEGGKLLGIDILDHIIIGDGRYVSLKDEGFVR
What are the official names of this protein?
UPF0758 protein MA_1979.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: ATPB_HISS2
Sequence: MSAGKIIQIIGAVIDVEFPQNAVPKVYDALKVESGLTLEVQQQLGGGVVRCIALGSSDGLKRGLKVENTGNPISVPVGTKTLGRIMNVLGEPIDEKGEIGAEEYWAIHRAAPSYEEQSNSTELLETGIKVIDLICPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMTESNVLDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLFFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDSTVVLSRNIASLGIYPAVDPLDSTSRQLDPLVVGQEHYDVARGVQGILQRYKELKDIIAILGMDELSEDDKLVVARARKIERFLSQPFFVAEVFTGSPGKYVSLKDTIRGFKGILDGEYDHIPEQAFYMVGSIEEVLEKAKKM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TRMD_THESQ
Sequence: MRITIVTIFPEMVEVIKKYGVIARAVERGIVEINVENLRDYTTDRHRTVDDYQYGGGYGMVMKPEPFFRFYESYVEKYGKPYVILTSPQGRIFNYKIAEELSKKDDIVIFCGRYEGIDERVMSIVDDEISIGDYILTGGELPAMVITDAVVRLVPGVVERESVERESFHQGLLDHPVYTRPYEYKGMKVPDVLLSGDHEKVELWRRKESIKKTLAKRPDLFLAKELDEMDKLAIIELFRELMEKC
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_PROA2
Sequence: MDKLVINGGHRLTGSVAASGSKNSALPLIAATLLCDNGTCRLERIPDLKDTRTFQELLAYLGADISYSGSRLSVSTQNLRAIQAPYELVKKMRASIYVLGPLLARFGRAEVSLPGGCAFGPRPIDLHLMAMEKLGASISIKNGYIEASIAKGRLTGGHIEFPVSSVGATGNALMAASLAEGTTTITNASIEPEITALCDFLMAMGADIKGAGTTALTIEGVPSLHPVAFTNIFDRIEAGTLLAAAAITKGTISITGIDHTHMGAVLKKFKQAGCRITIDDDSLTLQSPDRLEPTDIIASPYPFFPTDMQAQWIALMTQANGSSRIIDKVYHERFNHIPELNRLGAKIEINNNEAIVHGPQLLTGTTVMSTDLRASACLVLAGLVAQGTTEVLRVYHLDRGYEKIEEKLRHLGADIQRENYQEFST
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_BURA4
Sequence: MEKFTVHTGVVAPLDRENVDTDAIIPKQFLKSIKRTGFGPNAFDEWRYLDHGEPGQDNSKRPLNPDFVLNQPRYQGASVLLARKNFGCGSSREHAPWALQQYGFRAIIAPSFADIFFNNCYKNGLLPIVLTEQQVDHLFNDTYAFNGYQLTVDLDAQVVRTGDGREYPFEIAAFRKYCLLNGFDDIGLTLRHADKIRQFEAERLAKQPWLNNKLVG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: PTH_HELP2
Sequence: MTLLVGLGNPTLRYAHTRHNAGFDILDSLVSELDLSFTFSSKHNAYLCVYKDFILLKPQTYMNLSGESVLSAKNFYKPKELLIVHDDLDLPLGVVRFKKGGGNGGHNGLKSIDLLCSNSYYRLRVGISKGIDVIEHVLSKFHKNEEPLKNAVFEHAKNALKFFIESHDFNAMQNRFTLKKPLIIES
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_STAAN
Sequence: MSTIAKDQTQINDKIRAKELRLIGQDGEQIGVKSKREALEMAERVDLDLVVVAPNAKPPVARIMDYGKFKFEQQKKEKEMKKKQKIINVKEIRLSPTIEEHDFQTKLKNGRKFLTKGDKCKVSIRFRGRAITHKEIGQRVLEKYADECKDIATVEQKPKMDGRQMFIMLAPTAEK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CS3HE_METJA
Sequence: MDIINFFKQITDHEPYDYQIRAWEKINKIMELGGRVVIEIPTAGGKTEAAIIPYLYQFISNDWKVPRLIYVLPTRSLVEKQVERIRNYIKKILEIKGYSKDKVEELAKKIVQVEYGLEETHAFLGFVVLTTWDTFLYGLAAHRTVGDRFTFPCGAIAQSLVVFDEIQMYQDESLYMPRLIGLVVKRLVEANVPLVFMTATLPTELKKILGIHDEEPITVNPEDTKKPERGEVVVEFKEKLSDEELSNEIKKAINEGKKVLIIKNTVNSAIEVYEKVKQLGNSLLLHSRFTVEDRAEKEKDIDKAEIIVATQVVEAGLDLTNVGLVITDLAPLDALIQRIGRCARRKGERGKVIVVLPNFNEKINEDHREKVILGFKNIPFENAYVTLVNNKDYGRVIELTIETIEEKKGKSKIVPKKFYIGDLGNKTIRKLIENNKILKKKDLYFIPYSTQPYDPLIMIKSFDEVESVSEYLYDIIKAREALDRVYKEYYENNIVPKDYYSAYIYFRELKLFSTPPEYELKARPEMFAILYPLENAEEKVKNKEIIEFNPKYVIRVSYNWLKNKWEKFDKKFELIKEYDEKGWICSLKKAGKLQPYKIYIIDDKYYSKETGIII
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity.  Probably unwinds dsDNA templates, thus providing substrates for CRISPR-associated endonuclease Cas3-HD.  Unwinding is strongly increased in the presence of ATP, implying the helicase uses ATP to unwind substrate.
What are the official names of this protein?
CRISPR-associated helicase Cas3.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated helicase Cas3 family.
Protein: TPSDA_ABIGR
Sequence: MALLSIVSLQVPKSCGLKSLISSSNVQKALCISTAVPTLRMRRRQKALVINMKLTTVSHRDDNGGGVLQRRIADHHPNLWEDDFIQSLSSPYGGSSYSERAETVVEEVKEMFNSIPNNRELFGSQNDLLTRLWMVDSIERLGIDRHFQNEIRVALDYVYSYWKEKEGIGCGRDSTFPDLNSTALALRTLRLHGYNVSSDVLEYFKDEKGHFACPAILTEGQITRSVLNLYRASLVAFPGEKVMEEAEIFSASYLKKVLQKIPVSNLSGEIEYVLEYGWHTNLPRLEARNYIEVYEQSGYESLNEMPYMNMKKLLQLAKLEFNIFHSLQLRELQSISRWWKESGSSQLTFTRHRHVEYYTMASCISMLPKHSAFRMEFVKVCHLVTVLDDIYDTFGTMNELQLFTDAIKRWDLSTTRWLPEYMKGVYMDLYQCINEMVEEAEKTQGRDMLNYIQNAWEALFDTFMQEAKWISSSYLPTFEEYLKNAKVSSGSRIATLQPILTLDVPLPDYILQEIDYPSRFNELASSILRLRGDTRCYKADRARGEEASAISCYMKDHPGSIEEDALNHINAMISDAIRELNWELLRPDSKSPISSKKHAFDITRAFHHVYKYRDGYTVSNNETKNLVMKTVLEPLAL
What is the function of this protein?
Involved in defensive oleoresin formation in conifers in response to insect attack or other injury.  Involved in monoterpene (C10) olefins biosynthesis.
What are the official names of this protein?
Limonene synthase, chloroplastic, (-)-(4S)-limonene synthase, Agg-lim1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsd subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ORN_BURM9
Sequence: MTDISAVAGQPALVRNELNLVWLDMEMTGLDPDTDRIIEIAVVVTNSTLDIAVEGPVLAIHQSDETLAKMDDWNKNTHGRSGLIDRVRASSVTEADAAAQIAAFLAEHVPPGKSPMCGNSICQDRRFMARWMPELERFFHYRNLDVSTLKELCRRWQPAIYKGFQKRAMHTALADIHESIDELKYYRERFLIPAAPAGETA
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_CAMJJ
Sequence: MATFDDVKAVVVEQLSIDADAVKMESKIIEDLGADSLDVVELIMALEEKFEVEIPDSDAEKLIKIEDVVNYIDNLKK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_NOSS1
Sequence: MSSNPQHLSGNEIRTRFLDFYAQRGHQILASASLVPEDPTVLLTIAGMLPFKPIFLGQRTPEFKRATTSQKCIRTNDIENVGRTKRHQTFFEMLGNFSFGDYFKEQAIAWGWEISTEVFGLPKERLVVSVFEEDDEAYAIWRDQIGVTEARIKRMGADDNFWVSGPTGPCGPCSEIYYDFHPERGDDNIDLEDDTRFIEFYNLVFMQYNRDASGNLTPLQNKNIDTGMGLERITQILQRVPNNYETDLIFPIIETAAKIAGIDYHSSDESTKVSLKVIGDHVRSVVHMIADEIRASNVGRGYVLRRLIRRVVRHGRLIGISGEFINQVAETAIALSESAYPNVRQRETVIKAELEREEANFLKTLDRGEKLLAEIIAEVKKQGKTVISGKDAFTLYDTHGFPLELTQEIAEENNLTVDVEGFQKQMEIQQQGGRGAHETIDLTVQGSLDKLAEHIHATEFIGYSQATATAKVEVLLVDGVVQEEAEAGTEVQIVLDETPFYAESGGQIGDRGYISGDGIVVQVEDVKKESDFFVHFGRIERGTLRVGDNVTAQIDRAGRRRAQANHTATHLLQAALKTIVDGGISQAGSLVSFDRLRFDFNSPRGLTVEEIQQVEEQINTWIAEAHSAKIELLPLAEAKARGAVAMFGEKYGDEVRVIDFPGVSMELCGGTHVSNTAEIGVFKIISEAGVASGVRRIEAVSGLAVLDYLNVRDKVVKDLSDRFKVKPEELPERITTLQNELRTTEKQLETLKGQLAIAKSDSLLQTADTCGDYKIIVAQLEGVDPESLKSAAERLLQKIGNGAVVLGSVPEADKVSLVAAFSPEVNKKGLQAGKFIGAIAKICGGGGGGRPNLAQAGGRDASKLPAALEQAQSELKSALG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_AZOVD
Sequence: MAAVRSKICGITRVEDALVAAEAGVDAIGLVFYPKSPRAVTLRQAKAIVAALPPFVTAVGLFVNATRGEVGGILDELPLDLLQFHGDETPADCEGHGRPYIKALRVRPGEDIAARCLEYCNASGILLDAYVPGVPGGTGESFDWSLVPRGLPKPVILAGGLSVRNVRVAIARVSPYAVDVSGGVEAEKGVKDAEKVRAFIREVRNA
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: CP11A_PIG
Sequence: MLARGLALRSVLVKGCQPFLSAPRECPGHPRVGTGEGACISTKTPRPFSEIPSPGDNGWINLYRFWKEKGTQKIHYHHVQNFQKYGPIYREKLGNLESVYIIDPEDVALLFKFEGPNPERYNIPPWVAYHQHYQKPVGVLLKKSGAWKKDRLVLNTEVMAPEAIKNFIPLLDTVSQDFVGVLHRRIKQQGSGKFSGDIREDLFRFAFESITNVIFGERLGMLEEIVDPEAQKFIDAVYQMFHTSVPMLNLPPDLFRLFRTKTWRDHVAAWDTIFNKAEKYTQNFYWDLRRKREFNNYPGILYRLLGNDKLLSEDVKANVTEMLAGGVDTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAQGDTSKMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAVYAMGRDPAFFSNPGQFDPTRWLGKERDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVELQHFSDVDTIFNLILMPDKPIFLVFRPFNQDPLQA
What is the function of this protein?
A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:1773895, PubMed:2039527).  Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:1773895, PubMed:2039527).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule.  Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:1773895, PubMed:2039527).
What are the official names of this protein?
Cholesterol side-chain cleavage enzyme, mitochondrial, CYPXIA1, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450(scc).
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane.
Protein: GCST_BURMA
Sequence: MTVLKTTPLHAAHRALNARMVDFGGWDMPVNYGSQIEEHQAVRTDAGMFDVSHMCVVDFTGPRVRAFFEHAIANNVAKLQTPGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQGGFGLTIAPRRDFAIVAAQGPNARAKVWDTVPCARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEIIVPATHVEALWNALAERGVRPCGLGARDTLRLEAGMNLYGQDMDESVSPLDAGLAWTVDLSAPRAFVGRDALEAHGSRAAFVGLILQKENGRAGGVLRAHQKVATPHGEGEITSGTFSPSMQESIAFARVPKDVAIGDTVHVQIRDKQLPARVVKLPFVRNGKVLAA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: MURG_ALBFT
Sequence: MNMAPTLATACASLPPEGALAPRGGPSALMTHGTALIMAGGTGGHIFPGLALAHALRERGWRVHWLGGAGTASQPSMESQLVPPQGFAFESIDFSGVRGKGLGTLVRLPWRLLRACWQSVALLRRVQPDVVLGLGGYITLPAGLMSVLLGKALILHEQNSVAGMANKVLARFATRVFTAFPDVLPNGHWVGNPLRAAFLQVPDPATRFAGRAGPLKLLVLGGSLGARALNDIVPRALALLPPQARPIVTHQSGARQIDALRANYAGAGVQAELTPFIDDTAQAMAGADLVLCRAGASTVTEIAAVGAAALFVPFPSAVDDHQTSNARFLVDQGAGWLKPQSELSPEWLADMLQKTERIELMGRGLEAKKLQKLDATHKIVAACEEVVR
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BGAM_LACAC
Sequence: MAYTNNLQIIYGDATLGITGKNFHYLFSYERGGLESLNINNKEWLYRVPTPTFWRATTDNDRGNGFNLKASQWLGADMFTKCTKIELKVDDRQFDELPIAPINNQFSNHEYADHVQIAFWYQTLTNPATDVKIIYNIDNTGCINIVMHYFGKKGLPPLPVIGMRFIMPTAATGFDYEGLSGETYPDRMAGAKEGKFHVDGLPVTKYLVPQENGMHMQTKALKITRSSTLNNADQESEFSLKLKQDKQPFNFSCLPYTAEELENATHLEELPLARRTVLVIAGAVRGVGGIDSWGADVEKQYHINPEKDYEFSFNLN
What are the official names of this protein?
Beta-galactosidase small subunit, Beta-gal small subunit, Lactase small subunit.
What is the protein family that this protein belongs to?
Belongs to the bacterial beta-galactosidase small subunit family.
Protein: VKT24_CYRSC
Sequence: MGTARFLSAVLLLSVLLMVTFPALLSAEYHDGRVDICSLPSDSGDRLRFFEMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA
What is the function of this protein?
Toxin with inhibitory activity on serine proteases, but not on potassium channels (PubMed:24418069).  The recombinant toxin is active against trypsin (Ki=9. 61 nM), kallikrein (Ki=24. 8 nM), and chymotrypsin (PubMed:24418069).
What are the official names of this protein?
Kunitz-type U15-theraphotoxin-Hs1e, U15-TRTX-Hs1e, Huwentoxin HW11c24, Kunitz-type serine protease inhibitor HWTX-XI-IS24.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 03 (sub-Kunitz) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: URE3_THISH
Sequence: MELTPREKDKLLLFTAALLAERRKARGLKLNYPEAVALISAAILEGARDGRSVAELMSLGGEVLTRDEVMDGVAEMIPEVQVEATFPDGVKLVTVHEPVR
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2876_MYCTU
Sequence: MFGQWEFDVSPTGGIAVASTEVEHFAGSQHEVDTAEVPSAAWGWSRIDHRTWHIVGLCIFGFLLAMLRGNHVGHVEDWFLITFAAVVLFVLARDLWGRRRGWIR
What are the official names of this protein?
Uncharacterized protein Rv2876.
What is the protein family that this protein belongs to?
To M.leprae ML1584.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CBID_TREDE
Sequence: MKLDLYIDKDGQKLRCGYTTGSCAAAAAKAAALILGGETMTSVKIDTPAGLVLDLPVEHCRSYKNKDGTAIGEAAVQKDAGDDPDSTDGIYIYARVSYRNDGKVLIDGGEGIGRITKKGLFGEVGEAAINPVPRQMIEKEVLKVSKKGFNVEIFSPQGAEIGKKTFNKNIGVEGGISIIGTKGIVYPMSEDAIKKTIYLEIDGILQNSEKKEILLVPGNYGEGLKEKLNTIIDLPTVKISNYIGDSLSYAYSKGFKTMTLLGHIGKFAKLSIGIFNTHNRTADTRMEAFVYYLAMHGADKKTIETVNAFLTAEEAFNYLVENKIEMILKAMERGAEERIKKYLKDDSLSIRVLIYSMKYGLIE
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: CLPP_GEOUR
Sequence: MLVPIVVEQTGRGERSYDIYSRLLKDRIVFLGGAIDDAISNLVIAQLLFLEAEDPDKDIHLYINSPGGVVTAGMAIYDTMRYIKAPVSTICVGQAASMGAFLLSGGEKGKRFSLTNSRIMIHQPLGGFQGQATDIHIHAQEILRMKKKLNELMAEHTGQPVEKLEADTERDYFMSGEDAKNYGIIDSIISRNTITGGSR
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG191_VACCC
Sequence: MSSSVDVDIYDAVRAFLLRHYYNKRFIVYGRSNAILHNIYRLFTRCAVIPFDDIVRTMPNESRVKQWVMDTLNGIMMNERDVSVSVGTGILFMEMFFDYNKNSINNQLMYDIINSVSIILANERYRSAFNDDGIYIRRNMINKLYGYASLTTIGTIAGGVCYYLLMHLVSLYK
What are the official names of this protein?
Protein OPG191.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG191 protein family.