PharMolix/UniProtQA huggingface dataset:
Protein: AHT1_YEAST
Sequence: MDCKIKAAGKNSGIFHEGGTKSSKSFLTVFIRSVFPLSPSFPAGGGIWGPMEKKPGGVGKKKGSEKKTAQGNIFFSTERDAGQEKCGILYKHCFSILYGFFWKKADKPKEKTGNGSGLGIVFPIGQKKIPEPADSDIFLPCFRYAAASDFTKAKRFLVEITAVYWVSLEAQPSSASCLFILI
What is the function of this protein?
Multicopy expression suppresses glucose-uptake defects in various yeast mutants.
What are the official names of this protein?
Hexose transport activator protein.
Protein: SCC4_SCHPO
Sequence: MTGLNETDARILVTSRHLFLWPLAETYFKNAEKVLQDCGVCDSFGRLLSTGLQCLYSVLMDTKMEPRVELLTRKRICEVLLSHTVEYADVEAILNRALIIAEQHNLTEYKFSLQLLLSRVFCRTSPKAAKVLLTRCVREAEEYAKVAEIYHSNNQSNPHRWVYEFLLATLEFQNVSQVANSIHNYANHHKHQHLQLLAMILNQSLPMDEISTDSDQISILCLVTQIAQCLRKGEILLAREILPKIHSKLESETFVWPSSYIDFFIDDTSKISIKWMSINQLYLLIYLISGFCYISDSTSGRASRFLQEGLRITGDFKHQERCVLEYLESQKWINNITKDMKYYLIATYLSRSRLSKAERILQSTEDDQTGFLGILKGMYLQKRGDLKKAEVHYRETAKNFSFRTDTFIISTLNLINILEDSAAASRCLESIEPLCNKHEKKIFKLWLLVLKVIREGPQVHQSNVLPRVIQQSSEYANTQLQYISLTELSERFGKLEHAEKMAISALELAKKSKDELWCLISGRILEDFYRSVQKYDKMRQQALENSAYSKLIEDIYSFV
What is the function of this protein?
Involved in sister chromatid cohesion.  Forms a complex with mis4, which is required for the association of the cohesin complex with chromosomes.
What are the official names of this protein?
MAU2 chromatid cohesion factor homolog, Sister chromatid cohesion protein ssl3.
What is the protein family that this protein belongs to?
Belongs to the SCC4/mau-2 family.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with chromatin.
Protein: NFX1_BOVIN
Sequence: MAEAPPVSGAFKFNTDAAEFIPQERKNSGLYCGSQRRLDSNRIGRRNYSSPPPCHLSRQISYDDISAVHQHSFYPSGSKPKSQQTSFQSSVTNKSLKNHGLQNQPWQKLRSEKQHIRVKRAQGLIDQTSDAPGLENVAKSESGTNLREHSPSESEKEIVGADPRGAKPKKATQFIYSYGRGPKVKGKLKSEWGHRMTPKPEEAGPENTKPAGVIHPDSSDASSRKVVADGARRGEQRRHPQKRSPWEVEGARPRPGRNPPKQEGQRHTNAGSRDNMASIPKDDLNERPAKSTCDSGNLAVVSRSSRRADPEKCAVRRQDPQVASFPRGKQNHMLKNVETHTGSLIEQLTTEKYECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRRKQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCDNILNCGQHHCAELCHGGPCQPCRVILNQVCYCGSTSRDVLCGTDIGKSDGFGDFGCLKICGKDLKCGNHTCSQVCHPQPCQPCPRLPQLVRYCPCGQTPLSQLLELGSSGRKTCMDPVPSCGKVCGKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEDKCPPCTFLTQKWCMGKHELRSNIPCHLVDISCGLPCGATLPCGMHKCQRLCHKGECLGDEICKQPCTTSRANCGHPCMAPCHLSLPCPVTTCKAKIELQCECGRRKEIMVCSEASSTYQRIAAISMASKITDMQLGDSVEISKLITKKEIHQARLECDEECSALERKKRLAEAFHISDDSDPFNVRSSGSKFSDSLKEDARKDLRFVSDIEKEMEALVEAVNKGKSSKKSHCFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAVRGKSICPSTTLTGVLEKENQSRPPPPIAHHRQTDKNPGSSNLQKIAKEPVIDYFDVQD
What is the function of this protein?
Binds to the X-box motif of MHC class II genes and represses their expression.  May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma.  Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression.  Mediates E2-dependent ubiquitination (By similarity).
What are the official names of this protein?
Transcriptional repressor NF-X1, Nuclear transcription factor, X box-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the NFX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PNP_STRSV
Sequence: MTKQVFKTVFAGRELVVETGQVAKQANGSAVVRYGESTVLTAATMSKKMATGDFFPLQVNYEEKMYAAGKYPGGFNKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDEDASPQMAAMFGSSLALSISDIPFNGPIAGVQVGYVDGKFIINPSKEQKEVSLLELTVAGTKDAINMVESGAKELSEDIMLEALLKGHEAVKELIAFQEEIVAAVGKGKAEVELLHVDEELQAEIVAAYNSDLQKAVQVEEKLAREAATQAVKDQVTAVYEEKYADHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRKVDEIRPLDAEVDYLPRVHGSGLFTRGQTQALSVLTLAPMGETQIVDGLDPEYKKRFMHHYNFPQYSVGETGRYGAPGRREIGHGALGERALEQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGSNYTVLTDIQGLEDHFGDMDFKVAGTREGITALQMDIKIEGITAEILTEALAQAKKARFEILDLIEATIPAPRPELAPTAPKIDTIKIDVDKIKIVIGKGGETIDKIIAETGVKIDIDEEGNVSIYSSDQDAINRAKEIIAGLVREAKVDEVYHAKVVRIEKFGAFVNLFDKTDALVHISELAWTRTNNVEDVVQIGDEVDVKVIKIDAKGRVDASMKVLLPRPPKSDKPKHHHDKGHHPHKEYKGHKDHQESPKTEE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLSA_NATTJ
Sequence: MINNVNQEILRAFVENNRPLAHDGRLPTYIPALMNANKQDFGIHITELDGNSHYYGSFQIPFTVQSISKIITLAMAIMDNGEELVFSRVGMEPTEDKFNSILPLEMSSAYPPNPMINAGAIVVTSLIKGRTAGEQFERILDFTRALADNKNIQVDENAFLSERETGNMNRSLAYYLKDANVINGNVEEILETYFRHCSILVTAEDLSRIAYIFANDGKDIEGKQLIPAKVCKIVRAIMAMSGFYDESGEFAVRVGIPAKSGVGGGIIGVVPGYMGIGLYGPALNNKGTSIVGFNVLEELTSYLQVGIY
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: TRPA_NATPD
Sequence: MSLEDAFDEPAFVPYLAAGDPDFESSLAYVEALARGGADVIELGLPFSEPIAEGPTIQQAVVRSLEGGMTPERFFEFVETLDVDVPLVCMTYYNLIYQYGPAGSQPVVPFVERAAEVGLKGFVVPDLPAEEAGPLREACDEYGLDLVFIVAPTTAGDRLERMMEQVSGYVYVQARLGVTGAREDVSDRTAETLARLEAYDVPKAVGFGISSGEQAEAVVAAGADGVIVGSALVDIVAEGHENGDAPDVVADRLESLARELKSGAVAGKQRQPGPERT
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RL20_ECO45
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: CRT_PLAKN
Sequence: MKILKKKKKGNQQIVPDERYRELDSHAPNENEIADEAPMSRKILYYLKLVYHEIRENITIYLLIILYLCVCVMNKIMAKRTLKKIGNYSFVTSETHNTICMVVFFSLYFIFGRRVTSAKERHQNFGLQFLLISLLDACSVIIAFIGLTRTTGNIQSFVMQLSIPINMFFCFLILRYRYHLFNYVGASIIVLTIAIVEFILSFETQEENSIVFNLVLIASLIPMSFSNMTREIVFKKYKINILRLNAVVSFFQIFTSCLMLPMYTLPFLKQINLPFSEIGTNIKNGFRCLILGQNTIVENCGLGMAKMCDDCEGAWKTFLAYSFFNICDNLITSFIIDKFSTMTYTIVSCIQGPAIAIAYYFKFLAGDAVMKPRVLDFVTLFGYLFGSIIYRVGNIILEKKKMMEAGNDDDSEGELTNAESIITQ
What is the function of this protein?
May regulate endogenous transporter.
What are the official names of this protein?
Putative chloroquine resistance transporter, Probable transporter cg10, pkcg10, pfcrt homolog.
What is the protein family that this protein belongs to?
Belongs to the CRT-like transporter family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Localizes to the parasite digestive vacuole, the site of chloroquine action.
Protein: ATPF_PASMU
Sequence: MNLNATLIGQLIAFAIFVAFCMKFVWPPIIKAIEERQRSIANALASAEAARKEQADTKALVEQEITEAKMQAQQIIDLANKRRNEILEEVKVEAEATKAKIIEQGYAEVEAERKRVQEELRVKVASLAIAGAEKIVGRTVDEAANSDIIDKLVAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MCE_ASFM2
Sequence: MASLENLVARYQRCFNDQSLKNSTIELEIRFQHINFLLFKTVYEALVAQEIPSTISHSIRCIKKVHHENHCREKILPSENLYFKKQPLMFFKFSEPASLGCKVSLAIEQPIRKFILDSSVLVRLKNRTTFQISDLWKIELTIVKQLMGSEVSAKLTAFKTLLFDTPEQQTAKNMMTLINPDDEYLYEIEIEYTGKPESLTAADVIKIKNTVLTLISPNHLMLTAYHQAIEFIASHILSSEILLARIKSGKWGLKRLLPQVKSMTKADYMKFYPPVGYYVTDKADGIRGIAVIQDTQIYVVADQLYSLGTTGIEPLKPTILDGEFMPEKKEFYGFDVIMYEGNLLTQQGFEIRIESLNKGIKVLQAFNIKAEMKPFISLTSADPNVLLKNFESVFKKKTRPYAIDGLILVEPGNSYLNTNTFKWKPTWDNTLDFLVRKCPESLNVPEYAPKKGFSLYLLFVGISGELFKKLALNWCPGYTKLFPVTQRNQNYFPVQFQPSDFPLAFLYYHPDTSSFSDIDGKVLEMRCLKREVNHVSWEIVKIREDRQQDLKTGGYFGNDFKTAELTWLNYMDPFSFEELAKGPSGMYFAGAKTGIYRAQTALISFIKQEIIQKISHQSWVIDLGIGKGQDLGRYLDAGIRHLVGIDKDQTALAELIYRKFSHATTRQHKHATNIYVLHQDLAEPAKEISEKVHQIYGFPKEGASSIVSNLFIHYLMKNSQQVENLAVLCHKLLQPGGMVWFTTMLGERVLELLHENRIELNEVWEARENEVVKFAIKRLFKEDILQETGQEIGVLLPFSNGDFYNEYLVNTAFLIKIFKHHGFSLVQMQSFKDWIPEFQTFSKTLYKILTEADKTWTSLFGFICLRKN
What is the function of this protein?
Probably catalyzes the second reaction in the mRNA cap formation pathway (By similarity).  Forms a covalent complex with GTP (By similarity).
What are the official names of this protein?
mRNA-capping enzyme, VTF/CE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
What are the subcellular locations of this protein?
Virion. Note=Found in association with viral nucleoid.
Protein: PETH_UNKP
Sequence: MDGVLWRVRTAALMAALLALAAWALVWASPSVEAQSNPYQRGPNPTRSALTADGPFSVATYTVSRLSVSGFGGGVIYYPTGTSLTFGGIAMSPGYTADASSLAWLGRRLASHGFVVLVINTNSRFDYPDSRASQLSAALNYLRTSSPSAVRARLDANRLAVAGHSMGGGGTLRIAEQNPSLKAAVPLTPWHTDKTFNTSVPVLIVGAEADTVAPVSQHAIPFYQNLPSTTPKVYVELDNASHFAPNSNNAAISVYTISWMKLWVDNDTRYRQFLCNVNDPALSDFRTNNRHCQ
What is the function of this protein?
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle (PubMed:22194294).  Shows esterase activity towards p-nitrophenol-linked aliphatic esters (pNP-aliphatic esters), with a preference for short-chain substrates (C4 substrate at most) (PubMed:22194294, PubMed:24593046).  Cannot hydrolyze olive oil (PubMed:22194294).  Is also able to degrade poly(ethylene terephthalate), the most abundant polyester plastic in the world (PubMed:22194294, PubMed:32269349).  Can also depolymerize poly(epsilon-caprolactone) (PCL), a synthetic aliphatic biodegradable polyester (PubMed:22194294).
What are the official names of this protein?
Leaf-branch compost cutinase, LC-cutinase, LCC, PET-digesting enzyme, Poly(ethylene terephthalate) hydrolase, PET hydrolase, PETase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ELIA3_PHYCR
Sequence: MQFTALLAATAAALVGSVSATACTTTQQTSAYVTLVTLLSKSYFTTCASDSGYSMLTATALPTTAQYELMCASTACQEMIAEIITLSPPDCDLTVPTSGLVIDVYTYANGFASTCASLSSSSA
What is the function of this protein?
Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families.  Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins.  Might interact with the lipidic molecules of the plasma membrane.
What are the official names of this protein?
Highly acidic elicitin 26.
What is the protein family that this protein belongs to?
Belongs to the elicitin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RMD8_YEAST
Sequence: MSYKANQPSPGEMPKRSPSILVTDARTSKNRMSAPFAGHAAGSRKNMENAGVTKSQGVRSSAIGPSPLQSFTHPRRRSSGRFSDISIDNILSDNSDIPSARREERLSSSSSDRPRQYERLSSRRKMINPLPPRTSKTSQKLVLIPEDDNLNHFQTLPTNALDRQRPKVGSMKSNSFDRLPRYSKEKSMARITAYNVADGFNLNQLYKFLQETHEVSPRLYDECLYVAYTLPLLPGKGGFRIKSNLSKKTMGGKTLIDNLIDTSEQRDHHYEYYSGVETVEDANNNYELETSGNNNNANQDTTTVPDHLPNPVGQQDSFNPMEPQFFAEETPLEIEKRERTERINMLKKEENDSDASCGNDNNNKNNDKSKLYAVEGNDQYVQSSRSPASPSSISTPSPPSSSQNDFDRVYKMHRDNDHEGNDRHAEIFIFHYGVIVFWNFTEIQEKNILGDITFADYKNLMIRPLDEQDIETEQFHFEYDRDTERPRIFNDIVTLRSGDHIIELTLSHAIAQSSKLSRFESRISPILISVTKLPKRLALYGTLGLKREQLLKKSGKLFKLRVDVNLSSTILDTPEFFWSFEPSLHPLYVAMREYLEIDQRVQVLNDRCKVFLEFFDICVDSVAERNMARVTWWFILVILFGVIFSLTEIFVRYVIIHRHTST
What is the function of this protein?
Required for sporulation.
What are the official names of this protein?
Sporulation protein RMD8, Required for meiotic nuclear division protein 8.
What is the protein family that this protein belongs to?
Belongs to the RMD1/sif2 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AROK_SALTO
Sequence: MAPVCVLVGAPGSGKTTVGRALAELLGVEFRDTDLDIEATVGKPISEIFIDEGEAHFRTLERAAVATALATTAGVLALGGGAVLAEETRSALVGHTVVHLSVELPDAVRRVGLGAGRPLLAVNPRATLKYLLEQRRPHYAAVATATVVTDGRTPEQLAVEVAALLPS
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTD_ASPOR
Sequence: MEALPTYLESFWHSGGGTMGISILVMLSTFLALGTIFVYRIWLHPLSGFPGPKCCSVSSIPVAWAQLRGRNHEFVSSLHRKYGSVVRISPSELSFISGAAWNDIYSRSKGRPALERDRTFFNDMLVDPETITMANEATHSRIRRAMAPAFSPRALLEQEPIIQANIKLLMDKLEARAGSGGAPTDLRAWFNYTTFDLIGDLAFGESFGCLATSTCHEWVQFVLDHFYTSTLLHVVHRFHPFNRVLAALLPKSLIEKRKAHDSMTLTKVHRRLEVQGRRNDFTQHLLDAAEAGTLSSREVEKQASVLILAGSETTSVALTFAIYLVLTNKPVLDQLNDELHSTFKEEQEINLLSVNQLKYLHAVIQEALRFCPPISNGFPRQTPPQGATVDGMFIPGKTVVNINHWAAYRSPRNFTLPEQFLPERWLGDPRFDEDAKDVFQPFSVGPRNCIGKKFAYDSMKLILAKFLWRFKPTLLDKSRSWLAHQPTFVSFHQPPLLVDLEIKGSDAFPVRE
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of astellolides, drimane-type sesquiterpene esters that show antimicrobial, anti-inflammatory, and anti-tumor activities (PubMed:27628599).  The first step in astellolide biosynthesis is performed by the sesquiterpene cyclase astC that catalyzes the formation of drimanyl pyrophosphate from farnesyl pyrophosphate (PubMed:27628599).  Drimanyl pyrophosphate is then dephosphorylated by the sesquiterpene phosphatase astI to produce drimanyl monophosphate which is further dephosphorylated to drim-8-ene-11-ol by atsK (PubMed:27628599).  Drim-8-ene-11-ol is converted to confertifolin, probably by the cytochrome P450 monooxygenase astD and/or the dehydrogenase astE (PubMed:27628599).  The cytochrome P450 monooxygenases astB, astF and astJ then hydroxylate confertifolin at C6, C14, or C15 to form trihydroxy confertifolin (PubMed:27628599).  The nonribosomal peptide synthetase astA catalyzes ester bond formation between trihydroxy contifolin and benzoic acid (BA) or 4-hydroxy benzoic acid (4HBA), leading to the formation of dideacetyl astellolides A and B, respectively (PubMed:27628599).  Finally, the O-acetyltransferase astG converts dideacetyl astellolides A and B into deacetyl astellolides A and B (PubMed:27628599).
What are the official names of this protein?
Cytochrome P450 monooxygenase astD, Astellolide biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NU5M_DASNO
Sequence: MNLIMPFSIITLTILTIPIMMSYTNKYKTKSYPYHVTSSVSYAFMTSMIPTMMFLLSNQDSYISNWHWMTMQTMKLSLSFKLDFFSIIFVSVALFVTWSIMEFSLWYMHSDPYINQFFKYLLLFLITMMILVTANNMFQLFIGWEGVGIMSFLLIGWWYGRTDANTAALQAILYNRIGDIGFILTMAWLLLHLNSWDLQQIFMLKPTNLLPLLGLLVAAAGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLVRFYPLMQNNPTILTMTLCLGAITTLFTAICALTQNDIKKIIAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHSLNNEQDIRKMGGLLKAMPFTSSCLMIGSLALTGMPFLTGFYSKDLIIESANTSYSNAWALLITLLATSFTASYSTRLIYFSSLGPPRYLPLITINENNPNLLKPIKRLALGSIFAGFLISNYIPPLITPQTTMPLYMKLSALAVTIMGFMVAMGLNNITLNLKPERPNPLHSFSSLLGYYPNIIHRTTPYYILMMSQNLASLTDILWLEKLAPKSLSQMQLSASMITSNQKGLIKLYFMSFIISMTLATMLII
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SYGB_COLP3
Sequence: MTTETLLIELGTEELPPKSLKTLATAFYDNIKGQLDSHNLSYSDIKWFATPRRFAVQVFDLVEKQDDKIVEKRGPAVNVAFDDAGNASKAAQGWARSNGIEVDQAERLVTGKGEWLLHRATVSGKAVVELIPDMVTTALNKLPIAKPMRWGAERTQFIRPVQTLTMLFGSDIIAGEALGVSSSNQVQGHRFHHEGLVTINHANDYQAELAKAYVEVDFNERQNKIVAQIKQVANDIDAVALIDEELLNEVTALVEWPVTLVGTFDEDFLNVPAEPLIYSMKDHQKYFPVTDKNGQLVNKFIFVTNIESKDPNTIIFGNEKVIRPRLADAEFFFKTDKKQSLESRLKSLESVLFQKQLGTLKAKSERIASLSQFIAEQLNENAQDAYRAGLLSKTDLMSDMVLEFPQVQGTMGKYYALHDGENENIAQALEDQYRPRFAGDSLPEANIGCAVAISDKIDSLVGIFGINQAPKGDKDPFALRRAAIGSIRIIIEKQLDLDLSTLINKSIELFGDKLVNENTATDVLEFIMGRFRAFYQEQGISVDVIQAVLAKKPSAPLDFEKRIKAVTFFGELPEAATLAAANKRVGNILAKFDGELYQSFNTDLATEQAERDLADIYRDISLKVAPLMADKNYQAALSELAQLKAPIDTFFDGVMVMSDDEAVKINRLTLLNQIRNSFFAIADISVLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUTD_ECOLC
Sequence: MKLSLSPPPYADAPVVVLISGLGGSGSYWLPQLAVLEQEYQVVCYDQRGTGNNPDTLAEDYSIAQMAAELHQVLVAAGIEHYAVVGHALGALVGMQLALDYPASVTVLVSVNGWLRINAHTRRCFQVRERLLYSGGAQAWVEAQPLFLYPADWMAARAPRLEAEDALALAHFQGKNNLLRRLNALKRADFSHHADRIRCPVQIICASDDLLVPSACSSELHAALPDSQKMVMRYGGHACNVTDPETFNALLLNGLASLLHHREAAL
What is the function of this protein?
Involved in pyrimidine catabolism.  May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously.
What are the official names of this protein?
Putative carbamate hydrolase RutD, Aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Hydrolase RutD family.
Protein: RPB7_DANRE
Sequence: MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTVDEDVVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element.  The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft.  The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB7, RNA polymerase II subunit B7.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TBA1_NEUCR
Sequence: MRGEVVHIHLGQAGTQLGNSAWELYLLEHGLTQDGRKDPDSTVAGEGGSYDTFFTESSNGKYVPRSLFVDLDPSPIDEIRTGPYRQLFHPELLISGKEDAANNYARGHYTVGKEMAENVLDRIRKITDNCHSLQGFLVFHSFGGGTGSGFGALVLERLAQDYAKKCKLEFSVYPAPRVATAVVEPYNAVLATHSTLEHSDVTFLVDNEAVYDICRRNLDIPRPSYEHLNRLIAQVVSSITSSLRFDGALNVDLNEFQTNLVPFPRVHYPLISYAPVISATKSAHESFKTSELTLQCFEPNNQMVVCDPRNGKYMAVALLYRGDVVPRDTSAAVAALKAKSSFNLVEWCPTGFKIGINHQKPMSVPTASPADGGLASVDRSVSMLSNTTAIAEAWSRLDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLASLEKDYEEVAGDYNDVDVDAEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-A chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RPCF_SYNPY
Sequence: MNNLSPLEVAIADFQAAKTTPELIRATKNLCDLRTIEAIPILIEGLGFNNPAVASVATSGLIELGSQAVPSLLVSLDEKNYGSRAWVVRALASIRDPRSLDLLEHALATDIAPSVRRSAARGLAELNLIYPEDRSKLERCLLALLAAIKDDEWVVRYAVIFGIELHLRRYNPNNKNHCILALKQLSSDSESIKVIRLRAKLALQRLASS
What is the function of this protein?
An enzyme involved in the biosynthesis of bilin.  Might be involved in the specific attachment of phycoerythrobilin (PEB) to the R-phycocyanin II alpha chain.
What are the official names of this protein?
Bilin biosynthesis protein RpcF.
What is the protein family that this protein belongs to?
Belongs to the CpcE/RpcE/PecE family.
Protein: SP2AB_PAEPO
Sequence: MREGTGNNFMSLQFAAKSENEAFARVAVAAFISRLDPTMDELSDLKTVVSEAVTNSIIHGYDSDPSGVVTIKVGIEADVITLVVEDAGRGIEDLELAKQPLYTSKPELERSGMGFTIMENFMDEFEAVSEPGGGTSVRMKKRIESKKALYN
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: RLMG_AERHH
Sequence: MQTLLDTAHCRLTLYRYPRQLQDPLQAWDAADEYLINTLAEEPLERDGPVIIMNDGFGALAAYLHGHAPVSVTDSHISEQATLANLAENGLDPHAIRLQDALASLPDAPALVVIKVSKYQALLEQQLLALRQVATPATRVIAAGKAKDIHSSTLALFEKYLGPTRTSLAWKKARLIHCTPVATPTERPALANPFPTVWPLEGTDMLIHNHANVFSRTSLDIGARFMLDNLPIHSARKVIDLGCGNGVLGLSLLARDAEVEVTFIDESHMAVASARLNVEHNLPAALPRTHFLVNNCLDGVAVGSVDRILCNPPFHQLQAITDHIAWQMFSDAHRVLPKGGELWIVGNRHLDYHNKLKRLFANAQVVASNSKFVILKAIKR
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2B5_BUNMU
Sequence: AVCVSLLGAANIPPQHLNLYQFKEMIRYTIPCEKTWGEYADYGCYCGAGGSGRPIDALDRCCYVHDNCYGDAEKKHKCNPKTQSYSYKLTKRTIICYGAAGTCGRIVCDCDRTTALCFGNSEYIEGHKNIDTARFCQ
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
What are the official names of this protein?
Basic phospholipase A2 beta-bungarotoxin A5 chain, Beta-BuTX A5 chain, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CRBLF_VESMG
Sequence: FLPIPRPILLGLL
What is the function of this protein?
Mast cell degranulating peptide (By similarity).  Has little hemolytic activity.  Shows antimicrobial activity against the Gram-negative bacteria E. coli ATCC 25922 (MIC=30 ug/ml), the Gram-positive bacteria S. aureus ATCC 2592 (MIC=10 ug/ml) and the fungus C. albicans ATCC 2002 (MIC=25 ug/ml).
What are the official names of this protein?
Vespid chemotactic peptide 5f, VCP 5f.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Crabrolin subfamily.
What are the subcellular locations of this protein?
Secreted.