PharMolix/UniProtQA huggingface dataset:
Protein: REEP3_HUMAN
Sequence: MVSWMISRAVVLVFGMLYPAYYSYKAVKTKNVKEYVRWMMYWIVFALYTVIETVADQTVAWFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKSQGAITERLRSFSMHDLTTIQGDEPVGQRPYQPLPEAKKKSKPAPSESAGYGIPLKDGDEKTDEEAEGPYSDNEMLTHKGLRRSQSMKSVKTTKGRKEVRYGSLKYKVKKRPQVYF
What is the function of this protein?
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis.  Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
What are the official names of this protein?
Receptor expression-enhancing protein 3.
What is the protein family that this protein belongs to?
Belongs to the DP1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HIS8_XANCB
Sequence: MSTASVMDLVRDDLRAFAGYASARTSALQGDVWLNANESAWGNPADPDASTRRYPDPQPKGLRAALAQLYGCAPEQLLIGRGSDEAIDLLVRGLCVPERDAVVVTPPVFGMYAVCARLQNAPLVEVPLVDGADGLHADVPVIVQAALDAKAKLVFLCSPSNPAGSAIPLAEIEVALQALQGKAVVVVDEAYGEFSDVPSAIGLLARYDNLAVLRTLSKAHALAAARIGSLIANAELIALLRRCQAPYPVPTPCAVMAEQALSAPALAVTQRRVTEIRAERARLHAALVQVAGVRQVYPSQGNFLLVRFDDAEAAFQALLEAGVVVRDQRAVPRLSDALRITIGTPEQNDRVLGALQRKQEAA
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: NANA_ECO27
Sequence: MATNLRGVMAALLTPFDQQQALDKASLRRLVQFNIQQGIDGLYVGGSTGEAFVQSLSEREQVLEIVAEEAKGKIKLIAHVGCVSTAESQQLAASAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVGALKQTSGDLYQMEQIRREHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVKALKEGDIQTAQKLQTECNKVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFGPVDEKYLPELKALAQQLMQERG
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DADA_GRABC
Sequence: MRVLILGSGVVGVATAYYLSREGHEVVVADRRDGPGMETSFANAGQVSPGYSSPWAAPGIPLKVLRWMTQPRSPFVLRPKLDWAQWRWMTQMLGNCTANAYARNKARMVRLAEYSRDQLRDLRDETGIAYDNRERGTLQLFRTQKQMDHTADDIAVLKSYGVAYEVLDRAGCIAAEPGLQWAQVPLVGGLRLPGDETGDAHLFTRELARICMERGVSFLFGTQIHGFSTQGDKITAIRSSRGDLMADAYVCALGSYSPLLLKQIGIAAPIYPVKGYSMTIPITDETHAPVSTVMDETYKIAITRLGNRIRVGGTAELAGYDTRLRQERRMTLEGSVKELFPDSGDLPAATFWSGLRPMTPDGTPIIGPTRYRNLHLNTGHGTLGWTMSCGSGRLLADMISGKRPNIDHADLAIARYAG
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: ATP61_CROS5
Sequence: MDITPDSIIYWQWQWINLNATIVFSWLVMLILVLGSWLITRNLSIEPPLSRWQVALEIIVEQIRQQIRDASQQKADQFLPFIGTLFLFITMANLLTIFPVYQSPAGSLSTTAALALCVFVAVPIYGIKNVGITNYLRHYIQPTPVMLPFNLISEISRTVSLAIRLFGNIMSTSLLVAILISIVPLFFPAVMTLFGLLVGVIQAYVFTILAMVYIASGMNLQQRKTGNHHA
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a 1, ATP synthase F0 sector subunit a 1, F-ATPase subunit 6 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: COAD_YEAST
Sequence: MVEENSRVLIVLPYTPPSATLQRIIGQTIPFLRECQSQLDIVIVPEFKTSFQLDSALGKMYSITRDVLLGYGMINSGINIIFNNIHFVESNLQWKVVLLPQESTFETWKLELGQGQYHSIEHYALHDNIMEEIEGPKDANKFHVTALGGTFDHIHDGHKILLSVSTFITSQRLICGITCDELLQNKKYKELIEPYDTRCRHVHQFIKLLKPDLSVELVPLRDVCGPTGKVPEIECLVVSRETVSGAETVNKTRIEKGMSPLAVHVVNVLGGREEDGWSEKLSSTEIRRLLKSSASPTCTPQNPCV
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).  Plays a role in the physiological regulation of the intracellular CoA concentration.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, PPAT, Coenzyme A biosynthesis protein 4, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic CoaD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GLMM_HERAR
Sequence: MTRKYFGTDGVRGKVGVSPITPDFVMRLGYAAGSVLTKFETTKTPGSRPTVLIGKDTRISGYMLEAALEAGFSAAGVDVMLAGPVPTPAVAYLTRALRLSAGVVISASHNPYDDNGIKFFSASGNKLADATELEIEAALDVPMSCVASEKLGRVKRLDDARGRYIEFCKSTFPNELDLRGTKIVVDCAHGAAYHIAPDVFHELGAEVVAIGNQPSGFNINDKVGATAPAALVEAVRANQADIGIALDGDADRLIVVDASGRIFTGDEMLYIMVKDRMSVQAVAGAVGTLMTNMALEVAFRKMGIGFVRANVGDRYVLEALQERGWLLGGEGSGHMLFLDKHTTGDGIISALQILSALKRSGKTLAQLTADIAMFPQTLINVKVRPGFDWKKNAGLLAEKEQVEAELGDEGRVLIRASGTEPLIRVMVEAKNGEMADKMARRIAATLTV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RLME_METMJ
Sequence: MGSQWTKDSVYRKAMKAGYRARAAYKLLEIQQRNGIIRPDDNVVDLGAAPGSWLQVLRDLTDGRVIGVDLNPIAPMEGVTTIVGDFTDPLVQERIREEAGGVVSVVVSDASPKLSGQKSYDQARAIGLGEDALAFACTVLKPGGNMVIKSFQGELFGELIAETRKHFYSVRGYRTKASRKGSAETYIIAKNFKGTCDDAEGPL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFEK_SALTY
Sequence: MKKIVCAVVALLLTLPAWANVNAHEEARINAMLNALAQKKDLTFVRNGDAHNCEEAVSHLRLKLGNTRNRIDTAEQFIDKVASSSSITGKPYIVKIPGKSDENAQPYLHALIAETDKNVE
What are the official names of this protein?
Uncharacterized protein YfeK.
Protein: ATPA_LEPCP
Sequence: MQLNPAEISELIKSRIEGLGAATDVRNQGTVVSVTDGIVRVHGLSDAMAGEMLEFPGNVFGLALNLERDSVGAVILGEYEGISEGDTVRCTGRILEVPVGPELIGRVVNALGQPIDGKGPINAKMTDVIEKVAPGVIARKSVDQPVQTGLKSIDSMVPIGRGQRELIIGDRQTGKTAVAIDAIINQKGQNMTCVYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQYISAYTGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAFPGDVFYLHSRLLERAARVNADYVEAFTKGAVKGKTGSLTALPVIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAINAGISVSRVGGAAQTKLIKGLSGGIRTDLAQYRELAAFAQFASDLDASTRKQLDRGARVTELLKQAQYSPQPISLMGATLYAVNKGYLDDIEVKKVLAFESGMHQYLKTSHAALLQKLETTKALDKDAEAELQGAIAAFKKSFA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: METAS_VIBCH
Sequence: MPIRIPDQLPASDVLRNENIFVMSESRASTQEIRPLKVLLLNLMPKKIETETQFLRLLSNSPLQVDIELLRIDDRPSKNTPEEHLNTFYRQFELVKNRNFDGLIITGAPLGLVQFEDVAYWQHLQNIMAWAKAHVTSTLYICWAAQAGLKLLYNLPKRTREEKLSGVYYHDIHKPFHPLLRGFDDRFLAPHSRYADFDAEFLAEHTDLDILATSDVAGVYLAATKDKRNVFVTGHPEYDAYTLHGEYVRDLGEGLNPAIPVNYYPNDNPDNKPCASWRSHGHLLFANWLNYCVYQQTPYDLEKFSEANFTKDE
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRFA_SALNS
Sequence: MARKTLRARRFFSLIFPFFFITSVYAEQTPESAKTVTVEAKNEMFAPQHPDQYQSWKATSEQSAREDALAEDPRLVILWAGYPFSRDYNKPRGHAYAVTDVRETLRTGAPKTAEDGPLPMACWSCKSPDVARLIQQEGEDGYFHGKWARGGPEIVNDLGCADCHNTASDDFAQGKPALTLSRPYAERAMEAIGKPFDKAGRFDQQSMVCGQCHVEYYFDGKNKAVKFPWDEGMKVENMEQYYDAIAFSDWTNSLSKTPMLKAQHPEYETWSAGIHGKNNVTCIDCHMPKVQNAEGKLYTDHKIGNPFDNFAQTCANCHTQDKASLQKVVAERKQAIHDLKIKVEDQLVHAHFEAKAAWDAGATDAEMKPILNDIRHAQWRWDLAIASHGIHMHAPEEGLRMLGSAMDKAADARTKLARLLATKGITHEIPLPDISTKEKAQKAIGLNMQQINAEKQDFLKTVVPQWEDQARKNGLLSQ
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TRPA_CHLTE
Sequence: MKENRITRLVKQDKKLLIAYYMPEFPVPGATLPVLEALQESGVDLIELGMPYSDPIGDGSVIQDAAHKAISHGVHVGSIFELVRRARNGEGCKKITTPILLMGYCNPLIAYGGDCFMADAVKAGVDGLLIPDLPPEESEDFLERAKHFGLSVIYLISPVTPPDRIELIDSMSTDFSYCLAVNATTGTGKLDVAGMDEKIAEYLKRVRQHTKKKFVVGFGIKDRERVRKMWELADGAVVGSALLQHVATAKTPEETAELAAGFWKSLR
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: GPMI_LISIN
Sequence: MSKSPVAIIILDGFGKRAETVGNAVAQANKPNFDRYWANFPHGELKAAGLDVGLPEGQMGNSEVGHTNIGAGRIVYQSLTRIDKAIEEGEFQENKALNNAFTHTKENNSDLHLFGLLSDGGVHSHINHLVALLETAKDKGVKNVYIHAFLDGRDVAPQSSLEYLETLEKAISDLNYGAIATVSGRFYAMDRDKRWERVEKAYKAIVSAEGEKFEDPIELVKASYANDKNDEFVVPAIITKDGKPVATVKDNDAVIFFNFRPDRAIQLSNAFTDKEWDHFDRGANHPKNIKFVTMTLYNPSIDAEVAFEPIEMKNVIGEVLSNEGLSQLRIAETEKYPHVTFFMNGGRNEEFPGENRILINSPKVETYDLKPEMSAYEVTDALVEDIKNDKHDAIILNFANPDMVGHSGMLEPTIKAIEAVDENLGRVVDLILEKGGSAIIFADHGNSETMSTPEGKPHTAHTTVPVPVIVTKKGVTLREGGRLADVAPTMLDLLGVKKPAEMTGESLIQK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: CYSN_ECOHS
Sequence: MNTALAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGVLDQTRRHSFISTLLGIKHLVVAINKMDLVDYSEETFTRIREDYLTFAGQLPGNLDIRFVPLSALEGDNVASQSESMPWYSGPTLLEVLETVEIQRVVDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSGVESNVARIVTFDGDREEAFAGEAITLVLTDEIDISRGDLLLAADEALPAVQSASVDVVWMAEQPLSPGQSYDIKIAGKKTRARVDGIRYQVDINNLTQREVENLPLNGIGLVDLTFDEPLVLDRYQQNPVTGGLIFIDRLSNVTVGAGMVHEPVSQATAAPSEFSVFELELNALVRRHFPHWGARDLLGDK
What is the function of this protein?
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 1, ATP-sulfurylase large subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Protein: ISPG_BACC2
Sequence: MNEMTHRTKTRPVKVGNLTIGGNNELIIQSMTTTKTHDVEATVAEIKRLEEAGCQVVRVAVPDERAADAIADIKKQINIPLVADIHFDYRLALKAIEGGIDKVRINPGNIGRRHKVEAVVNAAKERGIPIRIGVNAGSLERHILEKYGYPTADGMVESALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAARAFDYPLHLGITESGTLFAGTVKSAAGLGAILSKGIGNTLRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRIEIDLISIANEVEEYISTLQVPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGQVVRKVPEETMVEELKKEIDVIAAEMAAEREKEKETQEQ
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: SYC_AZOC5
Sequence: MELRLYNTLTRSKDAFRPLDPNLVRLYVCGPTVYDHAHIGNARPVIVFDVLFRLLRRLYGADHVRYVRNITDVDDKINARAAERSISIRELTEETYAWFRDDTAALGCLRPDVEPRATEHILEMQALIERLVASGHAYVAEEHVLFHVPSMPEYGKLSRRPLDEMLNGARVDVAPFKRDPMDFVLWKPSTEGQPGWPSPCGIATPGRPGWHIECSAMSWRHLGETFDIHGGGIDLVFPHHENEIAQSRCAFDSGSMAQVWMHNGFLLVEGEKMSKSLGNFVTIRELLTDWPGEVLRLAMLSTHYRQPINWTRQGIGFAAKTLDKWYRVIGDVEAETGEGNPFESEIADRLGDDLNSPSAITHLHHLADVAEHEDASSALKRRFKSAANLMGLLHETETEWRARQRAAVSVDPDAIAALIADRNAARKARDFATADHIREQLASQGIVLMDNKDGTTSWELTR
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNB_HAHCH
Sequence: MFDLHKFSLRAQEIIEAGGFLYGAGWSPATSSNYSARIDDANIAITVSGKHKGRLQAQDIMVVDLQGRAVASQMKSSAETLLHTVIYDLKPNVGAVLHTHSVTATVLSRALRPNTEIVFEDYELQKAFRGVYTHEGRCVVPIFDNTQDIEALSALSVEYLKEHSDCPGYLIRGHGMYTWGETMAECLRHVEAMEFLLACELEMMRIKS
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: MSHC_KRIFD
Sequence: MQAWTKPDIPVVPGPARRLRLYDTASGGLVEVPPGPDGPARMYVCGITPYDATHMGHAATYVTFDLVNRLWRDAGYTVHYTQNITDVDDPLLERATATGVEWTDLAEREIQLFRDDMTALRVIPPQEYVGVVESIPLVVERIAELQQAGAVYDVDGDLYFAVKADPAFGGISSYDADTMRTLFGERGGDPDREGKRDPLDCLVWQQERPGEPAWDSPFGRGRPGWHIECSAIALQYLGMTIDVQGGGSDLIFPHHEMSASEAQCATGQHPFARAYVHQAMVGLDGEKMSKSKGNLVLVSRERQAGSDPMAIRLALLAHHYRTDWFWTDSELLDAQERLDVWRGAITRGTGPDGPAAVDALRAALTNDLDTTAALAAIDQWAETNGDDPEASALVALAVDALLGIKL
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: EFTS_COXBU
Sequence: MTTITPIMVKELRERTGAAVMACKKALQETNGDMEAAIDLLRKAGDAKAAKRAGKTAAEGVIVIAISKDQKKGFMAEVNSETDFVARDTNFMAFASKVAERGLAEGVSDVAATLALPIEPNSSSTIEDERKALVNRIGENIQIRRVASLSSDGVVGHYSHGGRIGVLLALDVPNPELAKGLAMHVAAFNPQAVSANQVSTEFVEKEKEIFLARAQETGKPANIIEKMVKGQVEKLLKEVSLEGQSFVKDPEKLVGDLLKAEKAKVLAFLRFEVGEGVEKESQNFADEVMAQVQGNR
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA_CLOBH
Sequence: MRTIAVLTSGGDAPGMNAAIRAVVRTGLEKGLKVMGIQRGYNGLINGEIFEMDTHSVSDIIQRGGTILRTARCEEFRTEQGREKAAKILKAFGIDGLVVIGGDGSFHGAQLLSKLGINTVGLPGTIDNDLAYTDYTIGFDTSINTVLDAINKLRDTSTSHERVSVVEVMGRNCGDIALYTGVAGGAESIIIPEKEYNADKLCKQILQGKLKGKMHNLVLLAEGVGGANELAKYIEEVTGIETRSTILGHIQRGGSPTCMDRILASRMAYKAVELLISGKSSRVVGIKNGKIIDMDIDEALAVERSFDQELYDIATILSK
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCRX_MYCTU
Sequence: MRRADGQPVTVLVVDDEPVLAEMVSMALRYEGWNITTAGDGSSAIAAARRQRPDVVVLDVMLPDMSGLDVLHKLRSENPGLPVLLLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDSGAQLVVGDLVLDEDSHEVMRAGEPVSLTSTEFELLRFMMHNSKRVLSKAQILDRVWSYDFGGRSNIVELYISYLRKKIDNGREPMIHTLRGAGYVLKPAR
What is the function of this protein?
Member of the two-component regulatory system TcrY/TcrX.
What are the official names of this protein?
Probable transcriptional regulatory protein TcrX.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1677_ARATH
Sequence: MGLCLAQLAVTCLFLVPFVLSQVTEFVSIDCGCSSNYTDPRTGLGWVSDSEIIKQGKPVTLANTNWNSMQYRRRRDFPTDNKKYCYRLSTKERRRYIVRTTFLYGGLGSEEAYPKFQLYLDATKWATVTIQEVSRVYVEELIVRATSSYVDVCVCCAITGSPFMSTLELRPLNLSMYATDYEDNFFLKVAARVNFGAPNMDALRYPDDPYDRIWESDINKRPNYLVGVAPGTTRINTSKTINTLTREYPPMKVMQTAVVGTQGLISYRLNLEDFPANARAYAYFAEIEELGANETRKFKLVQPYFPDYSNAVVNIAENANGSYTLYEPSYMNVTLDFVLTFSFGKTKDSTQGPLLNAIEISKYLPISVKTDRSDVSVLDAIRSMSPDSDWASEGGDPCIPVLWSWVNCSSTSPPRVTKIALSRKNLRGEIPPGINYMEALTELWLDDNELTGTLPDMSKLVNLKIMHLENNQLSGSLPPYLAHLPNLQELSIENNSFKGKIPSALLKGKVLFKYNNNPELQNEAQRKHFWQILGISIAAVAILLLLVGGSLVLLCALRKTKRADKGDSTETKKKGLVAYSAVRGGHLLDEGVAYFISLPVLEEATDNFSKKVGRGSFGSVYYGRMKDGKEVAVKITADPSSHLNRQFVTEVALLSRIHHRNLVPLIGYCEEADRRILVYEYMHNGSLGDHLHGSSDYKPLDWLTRLQIAQDAAKGLEYLHTGCNPSIIHRDVKSSNILLDINMRAKVSDFGLSRQTEEDLTHVSSVAKGTVGYLDPEYYASQQLTEKSDVYSFGVVLFELLSGKKPVSAEDFGPELNIVHWARSLIRKGDVCGIIDPCIASNVKIESVWRVAEVANQCVEQRGHNRPRMQEVIVAIQDAIRIERGNENGLKSSSSSSSKAQSSRKTLLTSFLELESPDISRNSLAPAAR
What are the official names of this protein?
Probable LRR receptor-like serine/threonine-protein kinase At1g67720.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TXND8_HUMAN
Sequence: MVQIIKDTNEFKTFLTAAGHKLAVVQFSSKRCGPCKRMFPVFHAMSVKYQNVFFANVDVNNSPELAETCHIKTIPTFQMFKKSQKVTLFSRIKRIICCYRSGFMSNLIFEFCGADAKKLEAKTQELM
What is the function of this protein?
May be required for post-translational modifications of proteins required for acrosomal biogenesis.  May act by reducing disulfide bonds within the sperm.
What are the official names of this protein?
Thioredoxin domain-containing protein 8, Spermatid-specific thioredoxin-3, Sptrx-3, Thioredoxin-6.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus.
Protein: RUVB_CUPPJ
Sequence: MIETDKFSAPDRVISATPASSREEAFERALRPKLLDEYVGQEKVRGQLDIFMHAARNRREALDHVLLFGPPGLGKTTLAHIIAREMGVNLRQTSGPVLERPGDLAALLTNLEANDVLFIDEIHRLSPVVEEILYPALEDYQIDIMIGEGPAARSVKLDLQPFTLVGATTRAGMLTNPLRDRFGIVARLEFYTAEELARIVTRSAQLLGAHIDPLGSLEIARRARGTPRIANRLLRRVRDYAEVKGDGTITREIADAALAMLDVDRVGFDLMDRKLLEAVLHKFGGGPVGVDNLAAAIGEERDTIEDVLEPYLIQQGYLQRTPRGRVATAAAYRHFGLASPQAGDSGDLIDGE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: YRRD_BACSU
Sequence: MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTISDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSCFTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRADSLVEVRKDEIVLNG
What are the official names of this protein?
Uncharacterized protein YrrD.
Protein: RNPA_PSYIN
Sequence: MVNYSFSRELRLLTPEDFKPVFKNAVPAVSPYLTLLARKNTLDHPRIGMAIPKKHIKRAVGRNRIRRIVREQFRHQQHQLPAIDIVVIAKAGIADLSNQEINKILDKLWRKLVQRCNG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: BABA1_XENLA
Sequence: MDNSTEETFSMDTSEPLEEGEQTHEQRPHTRSNPEGAEDRGVVHQAGVGSRSEGEGEAAQVEDPLPTTTTVPTNSTPPPTLEFQLKTPRVNCPEKVIICLDLSEEMSTQKLESFNGSKANALNSSQKMIEMFVRTKHKIDKRHEFALVVANNEAMWLSGFTSDPREVCSCLYDLETNVCESFNLEGLFNLIQQRTEFPVTDNVQTIPPPYVVRIILIYSRPASQPALALTDNMKKMLQCPYFFFDVIYIHNGSEEEELCWKDIFGFFSSLDSKGTSYKYEVSITGPALELHNCMARLLAHPLQRPFQSHAAYSLLEEEEESPESEVTV
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs.  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  In these 2 complexes, it is probably required to maintain the stability of babam2 and help the 'Lys-63'-linked deubiquitinase activity mediated by brcc3/brcc36 component.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1.  Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression.  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination.
What are the official names of this protein?
BRISC and BRCA1-A complex member 1, Mediator of RAP80 interactions and targeting subunit of 40 kDa, New component of the BRCA1-A complex.
What is the protein family that this protein belongs to?
Belongs to the BABAM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).