PharMolix/UniProtQA huggingface dataset:
Protein: YIAV_ECOLI
Sequence: MDLLIILTYVAFAWAMFKIFKIPVNKWTIPTAALGGIFIVSGLILLMNYNHPYTFKAQKAVISIPVVPQVTGVVIEVTDKKNTLIKKGEVLFRLDPTRYQARVDRLMADIVTAEHKQRALGAELDEMAANTQQAKATRDKFAKEYQRYARGSQAKVNPFSERDIDVARQNYLAQEASVKSSAAEQKQIQSQLDSLVLGEHSQIASLKAQLAEAKYNLEQTIVRAPSDGYVTQVLIRPGTYAASLPLRPVMVFIPDQKRQIVAQFRQNSLLRLAPGDDAEVVFNALPGKVFSGKLAAISPAVPGGAYQSTGTLQTLNTAPGSDGVIATIELDEHTDLSALPDGIYAQVAVYSDHFSHVSVMRKVLLRMTSWVHYLYLDH
What are the official names of this protein?
Inner membrane protein YiaV.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TOC33_ARATH
Sequence: MGSLVREWVGFQQFPAATQEKLIEFFGKLKQKDMNSMTVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVSRTMGGFTINIIDTPGLVEAGYVNHQALELIKGFLVNRTIDVLLYVDRLDVYRVDELDKQVVIAITQTFGKEIWCKTLLVLTHAQFSPPDELSYETFSSKRSDSLLKTIRAGSKMRKQEFEDSAIAVVYAENSGRCSKNDKDEKALPNGEAWIPNLVKAITDVATNQRKAIHVDKKMVDGSYSDDKGKKLIPLIIGAQYLIVKMIQGAIRNDIKTSGKPL
What is the function of this protein?
GTPase involved in protein precursor import into chloroplasts.  Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis.  Binds GTP, GDP, XTP, but not ATP.  Probably specialized in the import of nuclear encoded photosynthetic preproteins from the cytoplasm to the chloroplast, especially during early development stages.
What are the official names of this protein?
Translocase of chloroplast 33, chloroplastic, AtToc33, 33 kDa chloroplast outer envelope protein, Plastid protein import 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. TOC34 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane; Single-pass membrane protein. Note=May contain beta barrel transmembrane regions.
Protein: FLB_CAMJ8
Sequence: MGFRINTNIGALNAHANSVVNSNELDKSLSRLSSGLRINSAADDASGMAIADSLRSQAATLGQAINNGNDAIGILQTADKAMDEQLKILDTIKTKATQAAQDGQSLKTRTMLQADINRLMEELDNIANTTSFNGKQLLSGNFTNQEFQIGASSNQTIKATIGATQSSKIGVTRFETGAQSFTSGVVGLTIKNYNGIEDFKFDNVVISTSVGTGLGALAEEINKSADKTGVRATYDVKTTGVYAIKEGTTSQDFAINGVVIGQINYKDGDNNGQLVSAINAVKDTTGVQASKDENGKLVLTSADGRGIKITGDIGVGSGILANQKENYGRLSLVKNDGRDINISGTNLSAIGMGTTDMISQSSVSLRESKGQISATNADAMGFNSYKGGGKFVFTQNVSSISAFMSAQGSGFSRGSGFSVGSGKNLSVGLSQGIQIISSAASMSNTYVVSAGSGFSSGSGNSQFAALKTTAANTTDETAGVTTLKGAMAVMDIAETAITNLDQIRADIGSVQNQLQVTINNITVTQVNVKAAESTIRDVDFASESANFSKYNILAQSGSYAMSQANAVQQNVLKLLQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
What are the official names of this protein?
Flagellin B.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: GLYA_DEHMB
Sequence: MSFLKTSDPAVYNAIMQETTRLKETIDLIASENYTSKAVLEAQGSVFTNKYAEGYPGKRYYAGCEYADAVEELAIDRAKTLFHAEHANVQPHSGAQANMAAYFAMVKPGDTIMGLTLSHGGHLTHGSKVNFTGKLYHVIEYGLNAETERIDYDNLEKLAMEHRPRMIVTGASAYPRILDFERFRAICDKVDAKLMVDIAHIAGLVAAGLHPSPVPYADVVTSTSHKTLRGPRGGFILCKEQYAKAIDQAVFPVMQGGPLMQVVAAKAVAFQEAMQPGFVTYQKKTLENTQVMAEELRKLGLRLVSGGTDNHLVLVDLSPIGVNGYDAQLALRRAGIVINRNTVPFAENQTANVPAGIRLGCPAATSRGFGPAEIRQTVGWIGKILKNIGNEDVEKQVLAEVIHLCRKFPVPGIDI
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_DEHMB
Sequence: MKVTDKKIEGCQASITVEMDSTEVEEGLSKTYRRLVKKVEIPGFRKGKAPRDVFEKYVSREKMLDELVDDIVPEACQKAIQDEEIKPFATPKVAMVTTDPFVFSARIPLPPVVELGDYKTIRATKETVEIAEENIDTVVDQVLHQRATWETAERPVKMGDMLLMQVESTLNGEPYLNREDMQYSVREEAIYPAPGFGGYLVDMVAGEPKEFSIVFPEDHARAELAGKTAAFKVTVREIKEEKLPELNDAFAHELNPEFNTLSELRQRIRENMQDRQDDKAQAKFEDQIVEALIKMSKIDYPEVMVEAELDQIIEQQLQRLQSNVKSPEEFRAMLSQMTPEDMQQRYRPLAEQRVASSLALGKLATTENLVPNDEEVDAEIEKLITDAGDKKEEEKALYNQPETRGRLIQLLTARKTMAFIDEIALQPALEAVESKADEDEKTEEADK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: CATL1_BOVIN
Sequence: MNPSFFLTVLCLGVASAAPKLDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHGFRMAMNAFGDMTNEEFRQVMNGFQNQKHKKGKLFHEPLLVDVPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQREKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV
What is the function of this protein?
Thiol protease important for the overall degradation of proteins in lysosomes (By similarity).  Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling.  Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity).  In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (PubMed:12869695).  In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells.  Also mediates invariant chain processing in cortical thymic epithelial cells.  Major elastin-degrading enzyme at neutral pH.  Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity).  Secreted form generates endostatin from COL18A1 (By similarity).  Critical for cardiac morphology and function.  Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity).  Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity).
What are the official names of this protein?
Procathepsin L, Cathepsin L1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome. Apical cell membrane; Peripheral membrane protein; Extracellular side. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Secreted, extracellular space. Secreted. Note=Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages.
Protein: XIRP1_MOUSE
Sequence: MADAQMQVAPTPTIQMRTEEDLSLPHPSAPEGLPPPPPKETFSKFQQQRQASELRRLYKHIHPELRKNLEEAVAEDLAEVLGSEEPTEGDVQCMRWIFENWRLDAIGDHERPAAREPVSGGNVQATSRKFEEGSFTNSSDQEPEGLRPSGGDVQAARQMFETKPLDALRGQEEATQTTMREPAATGDVQGTRKLFETRPLDRLGSRPSIQEQSPLELRSEIQELKGDVKKTVKLFQTEPLCAIQDAEGTIHEVKAACREEIQSNAVRSARWLFETRPLDAFNQDPSQVRVIRGISLEEGALPDVSATRWIFETQPLDAIREIEVDEKDFQPSPDLIPPGPDVQHQRHLFETCSLDTLKGERETEAEVPPKEEVIPGDVRSTLWLFETKPLDAFRDQVQVGHLQRVGHQEGEGLVTECLPSNGTSVLPLSQGVPQNDGLKGDVKTFKNLFETLPLDSIGQGEPSAYGNINRGQNTDSAEQSQGSDAPVYAMQDSRGQLHALTSVSREQVVGGDVQGYKWMFETQPLDTLGRSPSTIDVVRGITRQEVVAGDVGTTRWLFETQPLEMIHQQEQQKPEEEEGKGPGGPPPELPKKGDVQTIRWLFETYPMSELAEKRESEVTDPVSKAETQSCTWMFGPQSLNPAEGSGEQHLQTSQVPAGDRQTDRHVFETESLPASNQSSGRKPVRYCSRVEIPSGQVSRQKEVFQALEAGKKEVPETTINLGSIPTGSVHKFTWLFENCPMGSLAAESIRGDNLQEEQPKGSAGHGTPERQETAAERTLRTLHATPGILHHGGILMEARGPGELCLAKYVLPSPGQGRPYIRKEELVCGELPRIVRQVLRRTDVDQQGLLVQEDTAGQLQLHPLMLPGPGDPGNIEDMDPELQQLLACGLGVSVSKTGLVMQETGQGLVALTAYSLQPQLTSRAPERSSVQLLASCIDKGDLHSLHSLRWEPPTDPSSGPATEESQRVPPTESIIHVTPLDSTMEMGQLRISGSTPCPPPSRAAGKVVLPNGKPVAQAPLQEARKKRDISHAGQKGKAASGRPEASPLGSGAPDLQEAMQNLRLATAEAQSLHQQVLSRHPQGSDPVATSMPVQDVLQASTPATGVTQGSIRPVAGSEARIPAVPRKLL
What is the function of this protein?
Protects actin filaments from depolymerization.
What are the official names of this protein?
Xin actin-binding repeat-containing protein 1, Cardiomyopathy-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the Xin family.
What are the subcellular locations of this protein?
Cell junction. Note=Colocalizes with actin stress fibers.
Protein: PUR7_METMA
Sequence: MKREQLYSGKAKTIYRTDDPDTLIAEFRNSLTAFNGEKKGEMELKGYYNAQISKKIFEMLEASGVKTHFVSMLTDIDMLVREVEIIKIEVIVRNIAAGSITRKYPIKEGTILKPPVLVFDFKSDEYGDPMLNDDIALALGIATREELAELRKLALRVNELLVPYLDEKGILLPDFKLEFGRREGEIVLADEISCDTCRFWDKKTGQSMDKDVFRFDKGDISKAYEEVARRIVPEIFE
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: ACCD_ALIFM
Sequence: MSWLEKIFNTSNIVSSRKASIPEGVWTKCTSCEQVLYSAELERNLEVCPKCDHHMRMKARKRLETFLDAEGRVEIGAELEPKDVLKFKDSKRYKDRISAAQKSSDETDALVVMKGTLLELPVVACAFEFSFMGGSMGSVVGARFVKAVDAAIENNCPLVCFSASGGARMQEALMSLMQMAKTSAALARLSRKGLPFFSVLTDPTMGGVSASLAMLGDINIGEPKALIGFAGRRVIEQTVREDLPEGFQRSEFLLEHGAIDMIVDRREMRQRIGGLMAKMTNQESPLVVPVDGSH
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y923_RICFE
Sequence: MFKKWLQPSNEELIKAIYVKNEAEAQKLIAKMDILELSKIYIDNTALIWAVDKGLEKVCEMLIPKMSEQAINHVTNNGNTALTLAASKGLEKICELLIPKMSPQAINHVTDNGNTALTWAAWKDLEKICEMLIPKMSPQAINQVTNNGNTALILAAWKGLEKICKILIPKMFEQAINQVTNKGCTALTLAADKDLKKIYELLINKMSIDAINHTLTSSHKEVKKFIQEKISYNNILAEKLALFLKESFLGKGKDNINNFVKMISAAKFYKIVNKKLLTEYLQKQEVDNSKFIIEEMNNFIKTHSFTIARIC
What are the official names of this protein?
Putative ankyrin repeat protein RF_0923.
Protein: RL15_RALSO
Sequence: MQLNNLKPAAGSKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGFHKVGFEGGQMPLHRRLPKRGFTSLTKEFTAEVRLGDLAGLPVAEIDLLTLKQAGLVGELVKSAKVILSGSIDKKVTLKGLGATAGAKAAIEAAGGSLA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PTPRD_HUMAN
Sequence: MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
What is the function of this protein?
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically.  Involved in pre-synaptic differentiation through interaction with SLITRK2.
What are the official names of this protein?
Receptor-type tyrosine-protein phosphatase delta, Protein-tyrosine phosphatase delta, R-PTP-delta.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CDC2C_ARATH
Sequence: MGCISSKNVSCLTDQGDSPLPEPGLLSTSQQHRVLIDHSLEASHNSKRSRKSRRLGGSDLRIGVSLGSSHRNIEAEQAAAGWPAWLCSAAAEAVHGWVPLKAEAFQKLEKIGQGTYSSVFRAREVETGKMVALKKVKFDNLQPESIRFMAREILILRKLNHPNIMKLEGIVTSRASSSIYLVFEYMEHDLAGLSSNPDIRFTEPQIKCYMKQLLWGLEHCHMRGVIHRDIKASNILVNNKGVLKLGDFGLANVVTPSNKNQLTSRVVTLWYRAPELLMGSTSYGVSVDLWSVGCVFAEILMGKPILKGRTEIEQLHKIYKLCGSPQDSFWKRTKLPHATSFKPQHTYEATLRERCKDLSATGVYLLETLLSMEPDKRGTASSALNSEYFLTRPYACDPSSLPKYPPNKEMDAKYRDDMRRKRANLKLRDSGVGRKHKRPHRAEYDPKNYAKLPIRKDTLEVKNIPNEASRATTTTHGNYYKVSDLPMTTGPASGFAWAVKRRKDPDNISTLTYYQPSSKSQLSGTSVAFAKNTFGLNLKPDNDSVWEVQGNNYDDVIEEVPSHESKLSRIGERHGSLDGSGLDFSQREEDSPKKTLEHLQFGKQSISGPLIFKSGKIDEILQRNESNIRQAVRKSHLQREQDDR
What are the official names of this protein?
Cyclin-dependent kinase C-2 C, CDC2CAt, Protein cdc2 C, Cyclin-dependent kinase-like protein 1, CDK-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOZ_ACIBY
Sequence: MARVTVEDCLDHVDNRFELVLVASKRARQLARQGMEPTVEWDNDKPTVVALREIAVGHVTKEILKQREQDYQTSSLDLALSTNSLNLEGFSF
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PAPX_ECOLX
Sequence: MNNTDLLEKIIRHQQNKDPAYPFREHLLMQLCIRVNKKIQNSTSEFFGAYGINHSVYMVLAILSMEEQHCLSPSEISQKLQFTRTNITRITDFLEKAGYIKRTDSREDRRTKKISLTSEGMFFIQRLTLAQNTYLKELWSNLTCDECEMFEVISKKLLAHFSDI
What are the official names of this protein?
HTH-type transcriptional regulator PapX.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATB_MARMM
Sequence: MSPGIGMPELLVVLVLALVVVGPQQLPVMMRKVGQMMAQARAMAKDFQNSFEEIGRETELSELRREIDALKQANPINQIHGELDKAARGTQDDDIRALKLKHVEQNQAETDADKAAKAAKLAALDSEGPQSTTPEADARADAAASADETERAAPVETTPAKPVDEIKGR
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MNTR_BACC3
Sequence: MPTPSMEDYIEQIYLLIDEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTSKGKKIGERLVYRHELLEQFMRIIGVDESKIYNDVEGIEHHLSWEAIDRIGDLVQYFEQDEVRVETLRGVQKANEEKSN
What is the function of this protein?
Central regulator of manganese homeostasis.
What are the official names of this protein?
HTH-type transcriptional regulator MntR, Manganese transport regulator.
What is the protein family that this protein belongs to?
Belongs to the DtxR/MntR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_CITBB
Sequence: MSAELKITLVRSAIGQSEKMKGRLLGMGLTKREKTVTLQDTPEIRGMIAKVAHLVRVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: P53_OTOBE
Sequence: DLWNLLPENNVLSPVLSPPMDDLLLSSEDVENWFDKGPDEALQMSAAPAPKAPTPAASTLAAPTPAISWPLSSSVPSQNTYPGVYGFRLGFIHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSESTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKRGEPCPEPPPGSTKRALPTGTNSSPQPKKKPLDGEYFTLKIRGRA
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.  Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity).  However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity).  In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.  Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.  Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.  LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation.  Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (By similarity).
Protein: SYY_BORGP
Sequence: MNLALNLLYKRGFLKQCTSLKVLSDLMDREKIVFYAGVDTTSSSLHIGHLIPFLAMMHLRQHGHMPIVLIGDSTTKIGDPSGKSEMRKILSSEVINNNALSIKNQLQKITRFSSSCFIHNSNWLDNLNYIEFLRDIGIHFSVNRMLSFETYKRRLDFGLSFIEFNYQLLQSYDYYMLNKIKNCKLQIGGDDQWGNIVSGVDLIRRKMGVEAFGLTFPLITRSDGKKMGKSEKGAVYLDSSLYSIYDFYQYFRNTSDSDVKTFLYLFTFLEEDEIESISNFKGNSLNKAKEILAFEITKIVHGEVEALKVQEASFAAFRGSGDRSNIPFFKFSFSGLEEEILLIDLMLDSKIVPSKSEGRRLINSGGVYINGKRVENQNHCITREDFNNNEIELRVGKKKFLRIVL
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCO1_DICDI
Sequence: MAALEVLFILFVSIASSLASEGVSWLLVYRTENYKRGKANIDRLQIQLDKLVDQESETSSLSKKGNKDKKIEKIEEQLKIANKELSFSKMKSMFAVAISMIALFSYLNRIFDGVVVCKLPFVPIGFLQGISHRTIAGDDYTDCSMTFIYAICSMFIRNNIQLILGTAPPKTKQANPWALPEEKKTR
What is the function of this protein?
Calcium-selective channel required to prevent calcium stores from overfilling.  Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity).
What are the official names of this protein?
Calcium load-activated calcium channel homolog, CLAC channel.
What is the protein family that this protein belongs to?
Belongs to the TMCO1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HSLO_ECOLI
Sequence: MPQHDQLHRYLFENFAVRGELVTVSETLQQILENHDYPQPVKNVLAELLVATSLLTATLKFDGDITVQLQGDGPMNLAVINGNNNQQMRGVARVQGEIPENADLKTLVGNGYVVITITPSEGERYQGVVGLEGDTLAACLEDYFMRSEQLPTRLFIRTGDVDGKPAAGGMLLQVMPAQNAQQDDFDHLATLTETIKTEELLTLPANEVLWRLYHEEEVTVYDPQDVEFKCTCSRERCADALKTLPDEEVDSILAEDGEIDMHCDYCGNHYLFNAMDIAEIRNNASPADPQVH
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_SERP5
Sequence: MAKKDYYEILGVSKTAEEREIKKAYKRLAMKFHPDRNQEQDAEARFKEIKEAYEILTDAQKRAAYDQYGHAAFEQGGMGGGGGFGGGAEFSDIFGDVFGDIFGGGRRQRASRGSDLRYNMELSLEEAVRGVTKEIRIPTLEECGVCHGSGAKPGSSPVTCPTCHGQGQVQMRQGFFTVQQACPHCHGRGQIIKDPCNSCHGHGRVEKAKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKAHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPAETQTGKLFRMRGKGVKSVRGGSQGDLLCRVVVETPVNLNDKQKQLLKELEESLGGPSGDKNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.