PharMolix/UniProtQA huggingface dataset:
Protein: CARA_NEIGO
Sequence: MNTPALLVLADGSVFHGTSIGYEGSASGEVVFNTSMTGYQEILTDPSYCKQIVTLTYPHIGNTGTNAEDEESRSVYAAGLIIRDLPLLHSNFRASESLHDYLVRNETVAIADIDTRRLTMLLREKGAQGGAILTGADATVEKAQELIAAFGSMVGKDLAKEVSCTETYEWTEGEWELGKGFVTPDKQPYHVVAYDFGVKTNILRMLASRGCRLTVVPAQTSAEDVLALNPDGVFLSNGPGDPEPCTYGIEAVQKLMESGKPIFGICLGHQLISLAIGAKTLKMRFSHHGANHPVQDLDSGKVVITSQNHGFAVDADTLPANARITHKSLFDNTLQGIELTDKPVSCFQGHPEASPGPQDVGYLSDKFIGNMKAAKQA
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: RR7_GINBI
Sequence: MSRRSTAEKETAKSDPIYRNRFINMLVNRILKHGKKSLAYRILYRAMKKIQQKTGKNPLSVSRQAIRGVTPDVTVKARRVGGSTYQVPIEIRSTQGKALAIRWLLGASRKRPGRNMAFKLSYELMDAARENGNAIRKKEETHRMAEAXRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MTNN_VIBA3
Sequence: MKIGIIGAMEQEVAILKAAISDITEVNKGGCTFFSGQLNGVDVVLLQSGIGKVAAAVGTSILLSEYQPDVVLNTGSAGGFDSTLNLGDVVISTEVRHHDADVTAFGYEIGQMAGQPAAFKADDKLMAVAEQALAQMEDKHAVRGLICTGDAFVCTAERQEFIRKHFPSVVAVEMEASAIAQACHQFQVPFVVVRAISDVADKESPMSFEEFLPLAAQSSSEMVIKMVALLK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: PDXJ_EHRRG
Sequence: MSSIALGVNIDHIATLRNARNTEYPDLVEIANIAVNNGADFITVHLREDRRHIRDSDVFRLKDNLNVPLNLEIAAIDEMLAIAIAVQPECVCLVPEKRQELTTEGGLDVKNMFTYLMPFVTQLHNHNIKVTLFVEPDINQINYAKKLSVDNIELHTGVYCNHNTQNELNRILEAAKHCYTNKIECHAGHGLDYQSAATIARVPYISALNIGHFLICEAVLHGIGTSIYKMKKVITNPL
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_FRATF
Sequence: MPRSLKKGPFVDHHLLKKVFEAQESNSKKPIKTWSRRSMIVPDMIGLTIAVHNGQQHVPVLMTEEMVGHKLGEFVVTRNYRGHAADKKAKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: Y3293_YERPA
Sequence: MIIPWQQVDSETLDNLLEAFVLREGTDYGEHERSLTEKVADVRRQLVSGEAVLVWSELHETINIMPRGSFRAGAEEQQ
What are the official names of this protein?
UPF0270 protein YPA_3293.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: TB22A_HUMAN
Sequence: MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK
What is the function of this protein?
May act as a GTPase-activating protein for Rab family protein(s).
What are the official names of this protein?
TBC1 domain family member 22A.
Protein: HSLU_ACISJ
Sequence: MSSMTPQEIVSELDRHIVGQNGAKRAVAIALRNRWRRQQVDASLRHEITPKNILMIGPTGVGKTEIARRLARLADAPFIKVEATKFTEVGYVGKDVDSIVRDLVEVAVKQTREADMKKVRVRAEDAAEDRILDVLIPPARGAGVDTARTGEPAGDSTARQVFRKKLREGQLDDKEIEIDLADARPQFEIMSPAGMEEMTEQLRGMFSQMGQERRRARKLKIAEAMKLLVEEEAAKLVNEEEVKTRALANAEQNGIVFIDEIDKVASRQEAGGADVSRQGVQRDLLPLVEGTTVSTKYGMVKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELTSLSVQDFEAILTQTHASLVKQYQALLETEGVTLDFTPEGITRLAHIAFEVNERTENIGARRLSTVMERLLDEVSYDATRLSGQTVVVDAGYVNARLQSLSQDEDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUS_AMPV1
Sequence: MSWKVVLLLVLLATPTGGLEESYLEESCSTVTRGYLSVLRTGWYTNVFTLEVGDVENLTCTDGPSLIRTELELTKNALEELKTVSADQLAKEARIMSPRKARFVLGAIALGVATAAAVTAGVAIAKTIRLEGEVAAIKGALRKTNEAVSTLGNGVRVLATAVNDLKDFISKKLTPAINKNKCDISDLKMAVSFGQYNRRFLNVVRQFSDNAGITPAISLDLMTDAELVRAVSNMPTSSGQINLMLENRAMVRRKGFGILIGVYGSSVVYMVQLPIFGVIDTPCWKVKAAPLCSGKDGSYACLLREDQGWYCQNAGSTVYYPNEEDCEVRSDHVFCDTAAGINVAKESEECNRNISTTKYPCKVSTGRHPISMVALSPLGALVACYDGVSCSIGSNKVGIIRPLGKGCSYISNQDADTVTIDNPVYQLSKVEGEQHTIKGKPVSSNFDPIEFPEDQFNIALDQVFESVEKSKNLIDQSNKILDSTEKGNAGFVMVIVLIVLLMLAAVGVGIFFVVKKRKAAPKFPMEMNGVNNKGFIP
What is the function of this protein?
Major determinant of the species specificity of RSV infection.  The trimer of F1-F2 (F protein) also facilitates the attachment to host cell by binding to host heparan sulfate.
What are the official names of this protein?
Fusion glycoprotein F0, Protein F.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
[Fusion glycoprotein F0]: Host Golgi apparatus membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: [Fusion glycoprotein F1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein. Note=Localized at the host apical membrane. SUBCELLULAR LOCATION: [Fusion glycoprotein F2]: Virion membrane. Host cell membrane. Note=Localized at the host apical membrane.
Protein: GNAT3_BOVIN
Sequence: MGIGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNGYSEQECMEFKAVIYSNTLQSILAIVKAMATLEIDYVNPRSAEDQQQLCAMANTLEDGSMTPELAEIIKRLWRDPGVQACFERASEYQLNDSAAYYLNDLDRIAAPGYVPNEQDVLHSRVKTTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFATTSIVLFLNKKDLFQEKVTKVHLSICFPEYTGPNTFEDAGNYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
What is the function of this protein?
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction.
What are the official names of this protein?
Guanine nucleotide-binding protein G(t) subunit alpha-3, Gustducin alpha-3 chain.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD166_RAT
Sequence: MASKGSPSCRLVFCLLISAAVLRPGLGWYTVNSAYGDTIVMPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLSLSENYTLSINNAKISDEKRFVCMLVTEDNVFEAPTLVKVFKQPSKPEIVNRAAFLETEQLKKLGDCISRDSYPDGNITWYRNGKVLQPVDGEVSILFKKEIDPGTQLYTMTSSLEYKTTKSDIQMPFTCSVTYYGPSGQKTIYSEQAIFDIYYPTEQVTIQVLPPKNAIKEGDNITLQCLGNGNPPPEEFMFYLPGQAEGIRSSNTYTLTDVRRNATGDYKCSLIDQRNMAASTTITVHYLDLSLNPSGEVTKQIGDTLPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEHDEADDISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
What is the function of this protein?
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts.  Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity).  Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity).  Mediates homotypic interactions with cells that express ALCAM.  Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction.  Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions.  Required for normal organization of the lymph vessel network.  Required for normal hematopoietic stem cell engraftment in the bone marrow.  Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow.  Promotes in vitro osteoblast proliferation and differentiation (By similarity).  Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity).  Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).
What are the official names of this protein?
CD166 antigen, Activated leukocyte cell adhesion molecule, HB2, KG-CAM, Protein MEMD, SB-10 antigen.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen- presenting dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse.
Protein: MEPA_ECOL5
Sequence: MNKTAIALLALLASSASLAATPWQKITQPVPGSAQSIGSFSNGCIVGADTLPIQSEHYQVMRTDQRRYFGHPDLVMFIQRLSRQVSNLGMGTVLIGDMGMPAGGRFNGGHASHQTGLDVDIFLQLPKTRWTSAQLLRPQALDLVSRDGKHVVPTLWKPEIFSLIKLAAQDKDVTRIFVNPAIKQQLCLDAGTDRDWLRKVRPWFQHRAHMHVRLRCPADSLECEDQPLPPPGDGCGAELQSWFEPPKPGTTKPEKKTPPPLPPSCQALLDEHVI
What is the function of this protein?
Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands.  Likely plays a role in the removal of murein from the sacculus.
What are the official names of this protein?
Penicillin-insensitive murein endopeptidase, D-alanyl-D-alanine-endopeptidase, DD-endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M74 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: VG38_HAEIN
Sequence: MPTFKIKPKTGLLIRDPETFELLSESGEDKPKISYWLNHLKNGDVELVTETTTKAKNSNKEQA
What are the official names of this protein?
Mu-like prophage FluMu protein gp38.
What is the protein family that this protein belongs to?
To phage Mu protein gp38.
Protein: RL19_STRA3
Sequence: MNPLIQSLTEGQLRSDIPEFRAGDTVRVHAKVVEGTRERIQIFEGVVISRKGQGISEMYTVRKISGGIGVERTFPIHTPRVDKIEVVRYGKVRRAKLYYLRALQGKAARIKEIRR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: SVN_SCYVA
Sequence: GSGPTYCWNEANNPGGPNRCSNNKQCDGARTCSSSGFCQGTSRKPDPGPKGPTYCWDEAKNPGGPNRCSNSKQCDGARTCSSSGFCQGTAGHAAA
What is the function of this protein?
Has strong anti-HIV activity against T-tropic strains of HIV-1 and weaker activity against M-tropic strains of HIV-1.  Inhibits HIV-1 fusion and infection of CD4 LTR beta-gal cells in vitro.  Inhibits fusion of HIV infected CEM-SS cells with uninfected CEM-SS cells, and fusion of HIV-1 Env expressing HL2/3 cells with CD4 LTR beta-gal cells.  Binds to HIV gp120, HIV gp160 and to a lesser extent HIV gp41.  Binding to HIV gp120 is glycosylation dependent.  Binds with high specificity to the tetrasaccharide Man-alpha-1,2-Man-alpha-1,6-Man-alpha-1,6-Man and also binds the higher-order oligosaccharides oligomannose 8 and oligomannose 9.  Does not bind to monosaccharides, complex or hybrid N-linked oligosaccharides or chitin.
What are the official names of this protein?
Scytovirin, SVN.
Protein: RL2_CAMHC
Sequence: MAIKSYKPYTKSRRYMTGLSSDDITAKASVKSLLVKIPASLGRNNNGRITSRHKEAGAKKLYRIIDFKRTKFGIPAKVEAIEYDPNRNCRIALLNYADGEKRYIIQPNELNVGDVISSAESGLDIKPGNAMKIKNIPVGTIIHAIELKPGKGAQLARSAGGYAQLMGREEKYVILRLPSGEMRKVLGECMATIGVVGNEEWANISLGKAGRNRYLGVRPQTRGSAMNPVDHPHGGGEGKTGPGRQPVTPWGQPTKGLKTRHKKASDKLIISRKKGK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ATG8_PODAS
Sequence: MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGGFETA
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Participates also in membrane fusion events that take place in the early secretory pathway.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
What are the official names of this protein?
Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier ATG8, Induced during the incompatibility reaction protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid- anchor. Note=Punctate structures under nutrient-rich conditions and large punctate perivacuolar structures and vacuolar lumen under nitrogen starvation conditions or heterokaryon incompatibility conditions.
Protein: GLPK_CARHZ
Sequence: MTKKYVLALDQGTTSCRAILFDRDSNIVGVAQKEFTQHYPKPGWVEHDPEEIWSTQYGVIAELMARYNVNPEEIAAIGITNQRETTVVWDRNTGKPVYNAIVWQCRRTAGICDELKAKGLEEKVRYKTGLVIDAYFSGTKIKWILDNVEGAREKAERGELLFGTIDTWLVWKLTGGKVHVTDYSNASRTMIYNIRELKWDEELLAELGIPASMLPEVKPSSYVYGETDPNVFFGHAIPISGIAGDQQAALFGQTCFEPGMAKNTYGTGCFMLMNTGDKVYESKNGLLTTIAWGIDGKVEYALEGSIFIAGAVIQWLRDGLKLIESAADSEYFASKVPDTGGVYIVPAFAGLGAPYWDMRARGTIVGLTRGTNKYHLVRAALESMAYQTRDVLSAMEADSGIKLQALKVDGGAVANNLLMQFQADILGVPVERPVNIETTAMGAAYLAGLAVGFWADKQELVAKYKVSRRFEPTMDEQTREKLYKGWQRAVTRAREWEVEE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: XERC_SALTI
Sequence: MTEVALSLDVSRFLRYLGVERQLSPITLQNYQRQLDAIIALAGETGLKSWQQCDAAIVRSFAVRSRRKGLGPASLALRLSALRSFFDWLVSQGELKANPAKGVSAPKAPRHLPKNIDVDDVNRLLDIDLNDPLAVRDRAMLEVMYGAGLRLSELVGLDIKHLDLDTGEVWVMGKGSKERRLPIGRNAVTWIEHWLDLRGLFASDEEALFLSKLGKRISARNVQKRFAEWGIKQGLNSHVHPHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates.  The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.  In the complex XerC specifically exchanges the top DNA strands.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAI_STAPU
Sequence: MSASYLPSILVPLVGLVFPAVTMASLFLYIEQDEIV
What is the function of this protein?
May help in the organization of the PsaL subunit.
What are the official names of this protein?
Photosystem I reaction center subunit VIII, PSI-I.
What is the protein family that this protein belongs to?
Belongs to the PsaI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SSRP_ANAPZ
Sequence: MDIVAENRKVRFNYTILSEYDAGIVLLGSEVKSLRQHKVSMGDAYVLESGMELWVHNLHISEYNRSSYKNHSPLRVRKLLLRRREINKIAGSVKASGITVVPRLVYFNERGLAKVRIALVKGKKLYDKREAIKAREWEREKGRTMKRDI
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: LPPE1_ARATH
Sequence: MAASSSLLLLLHCPTCNFYFDSSSYLKRSRLSSYSSIISRGSPLFVSSFGSMTVKRFSSRVGSRSNDGNEQFGALEQESFINNSSEIRKDLVTGGGIEAIVNRLSKWVVSVLFGSIILLRHDGAALWAVIGSISNSALSVVLKRILNQERPTTTLRSDPGMPSSHAQSISFISVFAVLSVMEWLGTNGVSLFLSGLILALGSYFIRLRVSQKLHTSSQVVVGAIVGSLFCILWYTMWNSLLREAFEASLLVQISVFLFAATFALAFAAYVVLNWFKDER
What is the function of this protein?
Exhibits phosphatidate phosphatase (PAP) activity in vitro.  May play a secondary role as PAP in plastids.
What are the official names of this protein?
Lipid phosphate phosphatase epsilon 1, chloroplastic, AtLPPE1, Phosphatidic acid phosphatase epsilon 1, Plastidic phosphatidic acid phosphatase epsilon 1.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: ITBP1_HUMAN
Sequence: MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSGQSNNNSDTCAEFRIKYVGAIEKLKLSEGKGLEGPLDLINYIDVAQQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQYDVLHRHALYLIIRMVCYDDGLGAGKSLLALKTTDASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSEKP
What is the function of this protein?
Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1.  Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis.  Stimulates cellular proliferation in a fibronectin-dependent manner.  Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner.  Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin.  Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool.  Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin.  Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis.  Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway.  Promotes transcriptional activity of the MYC promoter.
What are the official names of this protein?
Integrin beta-1-binding protein 1, Integrin cytoplasmic domain-associated protein 1, ICAP-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle. Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in a integrin-dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin- rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen.
Protein: COA2_YEAST
Sequence: MRAVTRNKIVNNLYFSTFLIAFASVAIGSVLPCPAHSVDSDSPAVQQHKLQLAHEQELKRKDALSKKI
What is the function of this protein?
Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane.  Seems to be involved in the SHY1-mediated step of cytochrome c oxidase maturation.  May aid in stabilizing an early COX1 intermediate containing the nuclear subunits COX5A and COX6.
What are the official names of this protein?
Cytochrome c oxidase assembly factor 2.
What is the protein family that this protein belongs to?
Belongs to the COA2 family.