PharMolix/UniProtQA huggingface dataset:
Protein: ELOV1_HUMAN
Sequence: MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN
What is the function of this protein?
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246).  This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.  Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA.  May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.  Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905).  Indirectly inhibits RPE65 via production of VLCFAs.
What are the official names of this protein?
Elongation of very long chain fatty acids protein 1, 3-keto acyl-CoA synthase ELOVL1, ELOVL fatty acid elongase 1, ELOVL FA elongase 1, Very long chain 3-ketoacyl-CoA synthase 1, Very long chain 3-oxoacyl-CoA synthase 1.
What is the protein family that this protein belongs to?
Belongs to the ELO family. ELOVL1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PYRB_POLNA
Sequence: MLYRRNPQLNKNGELIHLLSTEGLSKAILTQILDTAANFVSVSSREVKKVPLLRGKSVFNLFFENSTRTRTTFEIAATRLSADVINLDIARSSASKGESLLDTIANLSAMAADLFVVRHGESGAPYLIAQHVAPHVHVVNAGDGRHAHPTQGLLDMYTIRHYKKDFSNLTVAIVGDVLHSRVARSDIHALTTLGCAEVRVVGPKTLVPADMAQMGVRVCNTLEEGIRGADVIIMLRLQNERMTGALLPSSQEFSKSFGLTTDKLQLARPDAIVMHPGPINRGVEIDSAVVDGVQSVILPQVTFGIAVRMAVMSIVAGNEA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: YL059_YEAST
Sequence: MCMCVVLVYFSILLDKGTKVLYTHDNNWLVILVFYFLAFGSIMRISGRTCSEEMKKSFGQASYHNGLQNFSKESPVGVNLEKKKTHISCCIILATQRFLQKFSNKRLGNPHLHPTRESTFSRELATENNSGNFPVLLRYHIFRQLDIENGILLCQVLQALIIVQVMFS
What are the official names of this protein?
Putative uncharacterized protein YLL059C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NORM_ACIAD
Sequence: MAKVAGFRFELKQLFHLMWPILITQFAQAGLGLIDTIMAGHLSANDLAAIAVGVGLWMPVMLLFSAIMIATTPLVAEAKGARTPEHIPVIVRQSLWVAVSLGVIAMLILQLMPFLLPILGVPESLQPKAGLFLHAIGFGMPAVTMYAALRGYSEALGYPRPVTVISLLALVVLVPLNYIFMYGIGPVPHLGSAGCGFATAILQWLMLITLASYIYRAKAYQSTQVFSHWERINLTLVKRILKLGLPIGLAVFFEVSIFSTGAIVLSPLGDTLVAAHQIAMSVTSQLFMIPMSLAIALTIRVGMYYGEKNWVSMRLVQKLGLATATFFAMCTMSLIWFARPQIVAIYTQDPAVFDIALYLLLFAMAYQLMDAWQVGAAGCLRGMQDTKGPMWITLIAYWVVAFPVGTYLARVAKMGPAGVWLGLITGLSIACVLLLMRLYRNNHKLAQQS
What is the function of this protein?
Multidrug efflux pump.
What are the official names of this protein?
Probable multidrug resistance protein NorM, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: F16PA_PROA2
Sequence: MNKLITIERHFLEQQKSHPEATGELTDLLNDVAFAAKLVRREVVRAGLADILGMAGTTNVQGEEVKKLDLFANEKIINAIGEHGRFALMGSEENEGTIIPPNNDTGRYILLFDPLDGSSNIDVNVSVGTIFSIYRLTGDDPKEADINDCLQKGSEQVAAGYVIYGSSVMMVYTTGQGVHGFTYDPTIGEFLLSHENITTPERGKYYSINEGSLHQFNDSTVNFINYLKEDDEATGRPYSTRYIGSLVADFHRNLMTGGVFVYPATKGHPNGKLRLMYEANPLAFICEQAGGRATNGKERILDINPTELHQRTPLYIGSKEDVLKAEEFEKEG
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_SYMTH
Sequence: MAQPTYHIACLPGDGIGPEVTRGAVTVLQAAAAAYGFRLEFSEYLVGGAAYDAVGTPFPDETRDACDRADAILFGAVGGPRYEGLPWDLRPEAGLLAIRKRYDLYANLRPILLYPPLKDASPLKNEIIGGGVDFIIVRELVGGIYFGEPRGIETLPDGTRRGVNTEVYTDAEIARIARMGFEIARGRRRRLTSVDKGNVMEAGKLWRTVVDEVAREFPDVEVEHLLADNAAMQILRRPGDFDVMLASNLFGDFLSDEAAMLTGSIGLLPSASLGAARNRFGLPKGFYEPIHGSAPDIAGQDRANPLAAILCGAMLLRHSLGREDAARAVEQAVAAVLEEGLRTADITVPGTAVLGTAAMARAVADRVH
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUA1_ARATH
Sequence: MTRRCSHCNHNGHNSRTCPNRGVKLFGVRLTEGSIRKSASMGNLSHYTGSGSGGHGTGSNTPGSPGDVPDHVAGDGYASEDFVAGSSSSRERKKGTPWTEEEHRMFLLGLQKLGKGDWRGISRNYVTTRTPTQVASHAQKYFIRQSNVSRRKRRSSLFDMVPDEVGDIPMDLQEPEEDNIPVETEMQGADSIHQTLAPSSLHAPSILEIEECESMDSTNSTTGEPTATAAAASSSSRLEETTQLQSQLQPQPQLPGSFPILYPTYFSPYYPFPFPIWPAGYVPEPPKKEETHEILRPTAVHSKAPINVDELLGMSKLSLAESNKHGESDQSLSLKLGGGSSSRQSAFHPNPSSDSSDIKSVIHAL
What is the function of this protein?
Transcriptional repressor (PubMed:23888064, PubMed:24806884).  Direct regulator of the transcription of peroxidase (Prxs) and reactive oxygen species (ROS)-related genes via the recognition of 5'-ATCACA-3' motif (PubMed:24806884).  Binds to 5'-TATCCA-3' motif (TA box) and represses the activity of corresponding promoters (e. g.  sugar response genes) (PubMed:25920996).  Regulates hypocotyl elongation in response to darkness by enhancing auxin accumulation in a phytochrome-interacting factor (PIF) proteins-dependent manner.  Promotes lateral roots formation (PubMed:23888064).  Promotes cell expansion during leaves development via the modulation of cell wall-located Prxs (PubMed:24806884).  Plays a critical role in developmentally regulated and dark-induced onset of leaf senescence by repressing the transcription of several genes involved in chloroplast function and responses to light and auxin.  Promotes responses to auxin, abscisic acid (ABA), and ethylene (PubMed:25920996).
What are the official names of this protein?
Transcription factor KUA1, Myb-related protein H, AtMYBH, AtMYBS3, MYBS3-homolog protein, Protein KUODA1.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLNA1_PHAVU
Sequence: MSLLSDLINLNLSDTTEKVIAEYIWIGGSGLDLRSKARTLPGPVKNPSELPKWNYDGSSTGQAPGQDSEVIIYPQAIFKDPFRRGNNILVICDAYTPAGEPIPTNKRHNAAKIFSNPDVVAEEPWYGIEQEYTLLQKEVNWPVGWPVGGFPGPQGPYYCGVGADKAFGRDIVDAHYKACVYAGINISGINGEVMPGQWEFQVGPAVGISAGDELWVARYILERITEVAGVVLSFDPKPIKGDWNGAGAHTNYSTKTMRNDGGYEEIKSAIQKLGKRHKEHIAAYGEGNERRLTGRHETADINTFLWGVANRGASIRVGRDTEKAGKGYFEDRRPASNMDPYVVTSMIADTTILWKP
What are the official names of this protein?
Glutamine synthetase PR-1, Gln isozyme beta, Glutamate--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYD_SHEB8
Sequence: MRSHYCGDVNKSHVGQEVTLVGWVNRSRDLGGVVFLDLRDREGLIQVVYDPDLPEVFNVASTLRAEFCVQVKGLVRARPDSQVNGQMKTGEIEVLGQALTIINAADPLPLSMDNYQNNSEEQRLKYRYLDLRRPEMAQRLIFRAKVTSSVRRFLDSNGFLDIETPILTKATPEGARDYLVPSRTYKGQFFALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIETSFMSSEQVMAKTEEMMRGLFLEMLNVDLGEFPRMTYNEAMRRFGSDKPDLRNPLELVDIADLLKEVEFAVFSGPANDEEGRVAALRIPGGAALSRKQIDDYTKFVGIYGAKGLAWMKINDLSLGLEGIQSPVLKFLNESIVNEIVSRTGAQTGDIILFGADQATVVAESMGALRLKAGEDFNLLQGEWRPLWVVDFPMFEKINGNFHAVHHPFTAPRGVTAAELEANPANRVSDAYDMVLNGCELGGGSVRIHNQEMQSAVFRILGITDEEAKEKFGFLLEALRYGTPPHAGLAFGLDRIIMLMTGASSIRDVMAFPKTTTAACPLTNAPGFANPQQLAELGIAVVEKAVKTED
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTI1_STRCO
Sequence: MPLDAAPVDPASRGPVSAFEPPSSHGADDDDDHRTNASKELFGLKRRVVITGVGVRAPGGNGTRQFWELLTSGRTATRRISFFDPSPYRSQVAAEADFDPVAEGFGPRELDRMDRASQFAVACAREAFAASGLDPDTLDPARVGVSLGSAVAAATSLEREYLLLSDSGRDWEVDAAWLSRHMFDYLVPSVMPAEVAWAVGAEGPVTMVSTGCTSGLDSVGNAVRAIEEGSADVMFAGAADTPITPIVVACFDAIRATTARNDDPEHASRPFDGTRDGFVLAEGAAMFVLEDYDSALARGARIHAEISGYATRCNAYHMTGLKADGREMAETIRVALDESRTDATDIDYINAHGSGTRQNDRHETAAYKRALGEHARRTPVSSIKSMVGHSLGAIGSLEIAACVLALEHGVVPPTANLRTSDPECDLDYVPLEARERKLRSVLTVGSGFGGFQSAMVLRDAETAGAAA
What are the official names of this protein?
Actinorhodin polyketide putative beta-ketoacyl synthase 1, actI ORF1.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Protein: EFTS_LEVBA
Sequence: MASKITAAQVKELRDKTQVGMMDAKKALVASEGDMDKAIDFLREKGIAKAKKKSGNVAANGLARVKEDGNTAAIIEVNSETDFVATNDTFNALVDTIADTIAEKQPADLDAALALTTADGSTINDAIVKTTQVTSENVQLRRFAVVKKTDGQVFGSYLHQGGQIAAVVVLDGADEATAKDVAMHVAAINPEFVSRDDIPAERLDHEREVLKQEALNEGKPEKIVEKMVEGRLHKFLSEISLADQPFVKDGDQTVSQFVASKGGKLVTFVRYEVGEGIEKPVADLAKEVQDQING
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PICAL_RAT
Sequence: MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHAMSAAPQVASTWGDAVDDAIPSLNPFLTKSSGDVHLPISSDVSTFTTRTPTHEMFVGFSPSPVTQPHPSAGLNVDFESVFGNKSTNVAVDSGGGLLKPTVASQNQSLPVAKLPPNKLVSDDLDSSLANLVGNLGIGNGTTKNDVSCSQPGEKKLTGGSNWQPKVAPTTAWSAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVPGAQIQFM
What is the function of this protein?
Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells.  Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly.  Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.  In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8.  In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors.  Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).
What are the official names of this protein?
Phosphatidylinositol-binding clathrin assembly protein, Clathrin assembly lymphoid myeloid leukemia protein, rCALM.
What is the protein family that this protein belongs to?
Belongs to the PICALM/SNAP91 family.
What are the subcellular locations of this protein?
Cell membrane. Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Colocalized with clathrin in the Golgi area. Interaction with PIMREG may target PICALM to the nucleus in some cells.
Protein: HLGB_STAAW
Sequence: MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
What is the function of this protein?
Toxin that seems to act by forming pores in the membrane of the cell.  Has a hemolytic and a leucotoxic activity.  Promotes host AMFR-mediated inflammation by mediating 'Lys-27'-linked ubiquitination of TAB3, TAK1-TAB3 complex formation and phosphorylation of TAK1/MAP3K7.  In turn, activates host NF-kappa-B signaling pathway.
What are the official names of this protein?
Gamma-hemolysin component B, H-gamma-1, H-gamma-I.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
Protein: MYPC1_HUMAN
Sequence: MPEPTKKEENEVPAPAPPPEEPSKEKEAGTTPAKDWTLVETPPGEEQAKQNANSQLSILFIEKPQGGTVKVGEDITFIAKVKAEDLLRKPTIKWFKGKWMDLASKAGKHLQLKETFERHSRVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHESTGTTPNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPQVDVWELLKNAKPSEYEKIAFQYGITDLRGMLKRLKRMRREEKKSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEISENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGSTSAKQSDENGEAAYDLPAEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKVIAQ
What is the function of this protein?
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands.  Slow skeletal protein that binds to both myosin and actin (PubMed:31264822, PubMed:31025394).  In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase.  May modulate muscle contraction or may play a more structural role.
What are the official names of this protein?
Myosin-binding protein C, slow-type, Slow MyBP-C, C-protein, skeletal muscle slow isoform.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. MyBP family.
Protein: SMI19_DANRE
Sequence: MGGYGVMADEESLDYSVHEAWNEATNVYLLVILVSFALLMYARKNKRKIMRIFTLPPTVGSSSEPNFYDSLQKVRLRQQLEMYSLARKYDQQQSQSESVQLSME
What are the official names of this protein?
Small integral membrane protein 19.
What is the protein family that this protein belongs to?
Belongs to the SMIM19 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ENDOU_CAEEL
Sequence: MCSVLIFISILTVLAQCQKIPRFDVSNSELLAMAQKLRQVDTNRARPDQIKLNYQGHTVTRDDSDAAQAKLFSKVDTSLFRKPSYELYINLMDNFNRQTGVIEPRVSQAEEKNEVGKFLDYVLESRPMQELYNWFKAKGHPIATSPQVFRFWIGQLWFSHYSRALGRPDTSGFEHVFIGEAKNGEISGMHNWVRFYVLENNRTENFDYKGFTVKRFNIMAALKFTWDGLLKRAGSILIGTSPEFDMALYTMCFLSRRGRETCDVEFDGCPLQITSFEIMQQNKVYIGSIYPTAGRITDQCRAQNRFN
What is the function of this protein?
Catalyzes RNA cleavage releasing a product with a 2',3'-cyclic phosphate at the 3'-end.
What are the official names of this protein?
Endoribonuclease endu-1, Poly(U)-specific endoribonuclease homolog, Uridylate-specific endoribonuclease homolog.
What is the protein family that this protein belongs to?
Belongs to the ENDOU family.
What are the subcellular locations of this protein?
Secreted.
Protein: FLPA_METMJ
Sequence: MKWLGNVLVSPGEGGVYGERTLDGYRVWDPYRSKLAALYTLGGGVELTPEMRVLYLGAANGTTVSHVADYVETVYAVEFAPRPMQDLLEVARRRRNIVPIMADASRPEEYAPFMEAVDLVYQDVAQPNQVEIAERNLVFLKPGGHLVLMLKTRSVDVRRDPAEVLAGARTGLEERLDIADVRWLDPYHHDHAAIVCSRRE
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: NBLIK_CORJK
Sequence: MAEEENKKFKVNANDAVNLAAEQSKSTSDKNLPEFGDMPIPDDTANLRKGPNLHDGLLALLPLIGVWRGQGQAAPPGEEEFTFGQQVVFAHDGENRISYDSRTWRMDDDGKPTEIPDRRESGFLRINDDDEIEMILTHSDGMVEILYGSPLNERAWQLESASTMATATGPTNLGPGKRLYGLMPNNDLGWVDERLIDGEMVPWQSAQLSRVVG
What are the official names of this protein?
Ferric nitrobindin-like protein.
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: TM175_BOVIN
Sequence: MSGPQAPEPTLEGQADASAGSPDEDAAEGIQHSHRMLSFSDALLSIIATVMEFDKSVQRLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKIDDTLALLNLFSLMVTFPEVPLGIFLFCMCVIAIGAVQALIVLYAFHFPHLLSPQIERSAHRGLYRQRVLGIIVRGPALCLAAAGFSLFFYPASYLLMAMVIVLPHVSKAAGWCRAQLVGPREPPAHSVEVFTFDLHEPLSKERVEAFSDGVYAIVATLLILDICEDNVPDAKDVKEKFQGSLVAALGESGPHFLAYFGSFATVGLLWFAHHSLFLHIRRATQPMGLLNTLSLAFVGGLPLAYQQTSAFTKQPRDELESVRISCAIIFLASIFQFAIWTTALLQEGETLQPSARFGGREHAFMFAKLALYPCASLLAFACTCVLSSFSTAIFHAMQIAVPFAFLLLRLLVRLALAGLRALRGLVGPVLARPAPGAADEAQSPLLPAPC
What is the function of this protein?
Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH.  Activated at low pH (under pH 4. 6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis.  Regulation of lumenal pH stability is required for autophagosome-lysosome fusion.  May also act as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes.  The potassium channel activity is however unclear as it was tested in non-physiological conditions for a lysosomal channel.  Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors.  The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation.  The lysoK(GF) complex is required to protect neurons against stress-induced damage.
What are the official names of this protein?
Endosomal/lysosomal proton channel TMEM175, Transmembrane protein 175.
What is the protein family that this protein belongs to?
Belongs to the TMEM175 family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Protein: SYTC2_XENTR
Sequence: MAAHIAQRLTVQEQEIRRLNEEIGRLLELGLQGSVEHSPNPVLEQLRAENEKLKYRISHLQRSLREEQERARPGQYGEPGLKDAAPVEEPKQQNNKAKEKGQATKGENSVGGKPSACEGNKKNEKKAGKEVDGHKQEGPCAPGFIKDRLALYETLKNEHDALLAARAAHQSKPIKITLADGKQVDGESWKTTPYQVAIGISKGLADNVVIAKVNNELWDLDRPLEQDSNVELLKFDSEEAQAVYWHSSAHILGETMENFYGGCLCYGPPIENGFYYDMYLDGRGVSSNEFPSLENMCKAIIKEKQPFERLEVSKDLLLEMFKYNKFKCRILNEKVDTPTTTVYRCGPLIDLCRGPHVRHTGKIKTLKIYKNSSTYWEGRADMETLQRIYGISFPDSKLMKEWEQFQEEAKNRDHRKIGRDQELFFFHDLSPGSCFFLPRGAHIYNTLTDFIKGEYQIRNFTEVASPNIYNSKLWEMSGHWQHYSENMFSFEVEKETFALKPMNCPGHCLMFGHRPRSWRELPLRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCTMDQIQEEMNGCLQFLQSVYKVFGFTFQLHLSTRPENYLGEIEIWNEAEKQLESSLNQFGEPWKLNPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKKRPVIIHRAILGSVERMIAILCENYGGKWPFWLSPRQVMVIPVGPSCDEYAQQVCKDVFEAGFMAEVDLDHSCTLNKKIRNAQLAQCNFILVVGEKEKTDSAVNVRTRDNKVHGEILLTSAIEKLKTLKKLRSKNAEEEF
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.
What are the official names of this protein?
Threonine--tRNA ligase 2, cytoplasmic, Threonyl-tRNA synthetase, ThrRS, Threonyl-tRNA synthetase protein 3.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Also detected at lower levels in the nucleus.
Protein: PXR1_BOTFB
Sequence: MGLAAPKNKIKLSHDPNNTRWSGNTDSFGHRMMKSQGWTPGEYLGAKDAAHAEFHTEANASHIRVVIKDNTLGLGAKIGSGVGHGECTGLDVFQNLLGRLNGKEEAEIEKEQKGREDLKRAIYAERKWGSIRFVKGGVLIGDKIQDLIDGEKERLKALEIKEKAAESSSEESDSSSDEEEEKSPEPVAEKKKSSKRKREEQEDEEKTSSKKSKKEKKEKKEKKSKKRQSEDEDEKDKSESKKSKKSKKDRKSKSKSTSEAEDETLDESALKARKKEKKEKKRKEKEAAGADTEEASSTSKSSKKSKKDKHKSPSTSKTSTKESTPIVSESSGRSTPMGIRSIRARHIAQKRMASMDVASLNQIFMIKS
What is the function of this protein?
Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase.
What are the official names of this protein?
Protein pxr1, PinX1-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the PINX1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: VKT2M_HETCR
Sequence: GSICLEPKVVGPCTAYLRRFYFDSETGKCTPFIYGGCEGNGNNFETLRACRAICRA
What is the function of this protein?
This recombinant serine protease inhibitor inhibits trypsin (Ki=210 nM) (Ref. 3).  In contrast to other sea anemone serine protease inhibitors, it does not significantly blocks histamine influence on intracellular calcium concentration in murine bone marrow-derived macrophages (tested at 1 and 10 uM) (Ref. 3).  In vitro, it shows cytoprotective activity in the oxidative stress agent 6-hydroxydopamine (6-OHDA)-induced neurotoxicity model (PubMed:33802055).  In this model, it decreases reactive oxygen species (ROS) levels, and increases cell viability in a correlated manner (PubMed:33802055).  It is possible that the observed effect is due to the ability of this peptides to act as free-radical scavenger (PubMed:33802055).  In vivo, it shows analgesic activity, since it increases hot plate and tail flick withdrawal latencies, when using a mice thermal pain stimulation model (PubMed:25937220).
What are the official names of this protein?
PI-stichotoxin-Hcr2m, PI-SHTX-Hcr2m, Kunitz-type serine protease inhibitor HCGS1.10.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.