PharMolix/UniProtQA huggingface dataset:
Protein: OSW5_YEAS2
Sequence: MVSTATFFFFVYLTLFVVIGFFSSLFIIPLLGISFVFAIGVVSFGFCSNMSFKMAQLIYVRADAFLKKVLDKMALQTQPAQLQEPQEPLSTLRPVSNPTIPSPLRQTARPSKFVTEEDVIFEPVSAQSAIARSLETTANKAGNKFQLS
What is the function of this protein?
Involved in spore wall assembly.
What are the official names of this protein?
Outer spore wall protein 5.
What is the protein family that this protein belongs to?
Belongs to the OSW5 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MDH_AQUAR
Sequence: MAKTPMRVAVTGAAGQICYSLLFRIANGDMLGKDQPVILQLLEIPNEKAQKALQGVMMEIDDCAFPLLAGMTAHADPMTAFKDADVALLVGARPRGPGMERKDLLEANAQIFTVQGKAIDAVASRNIKVLVVGNPANTNAYIAMKSAPSLPAKNFTAMLRLDHNRALSQIAAKTGKPVSSIEKLFVWGNHSPTMYADYRYAQIDGASVKDMINDDAWNRDTFLPTVGKRGAAIIDARGVSSAASAANAAIDHIHDWVLGTAGKWTTMGIPSDGSYGIPEGVIFGFPVTTENGEYKIVQGLSIDAFSQERINVTLNELLEEQNGVQHLLG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: NFE2_RAT
Sequence: MPPCPPQPNRNRLPQLPTGELGEMELTWQEIMSITELQGLNVPSEPSFEPQAPTPYPGPLPPPTYCPCSIHPDAGFTLPPPPYELPASTPHAPDLPYSYGNIAIPVSKPLTLSGLLNEPLPDPLALLDIGLPVGQPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVDMYPVEYPYSLMPNSLAHPNYTLPPTETPLVLESSSGPVRAKPAVRGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLAQYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLGSERERLLRARGEADRTLEVMRQQLTELYHDIFQHLRDESGNSYSPEEYVLQQAADGAIFLVPRGTKMEATD
What is the function of this protein?
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation.  Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR).  This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters.  Requires MAFK or other small MAF proteins for binding to the NF-E2 motif.  May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity).
What are the official names of this protein?
Transcription factor NF-E2 45 kDa subunit, Leucine zipper protein NF-E2, Nuclear factor, erythroid-derived 2 45 kDa subunit, p45 NF-E2.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. CNC subfamily.
What are the subcellular locations of this protein?
Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
Protein: LEPA_PARUW
Sequence: MHCHNLNNIRNFSIIAHIDHGKSTLADRLLELTNTVAARDMQEQLLDDMDLERERGITIKAHPVTMYYKGNDGQTYQINLIDTPGHVDFTYEVSRSLAACEGAILVVDAGQGVQAQSLANVHLALERNLEIVPVINKIDLPAADVEGVRKQIEDVIGLDASDAIGCSAKSGLGVKDVLERILTAVPPPQEPKDNLLRALVFDSHYDVYRGVMVYIRVMSGEIKRGSLIKMMATNKNFEVLEVGMFTPKEKPVEQLRPGEVGYMIANIKTPSDVKIGDTITLQKYPAPEALPGFKIISPVVFAGIYPIDATEFEGLRDALGKLQLNDSALHIEQESSTALGFGFRCGFLGLLHLEIVFERIQREFNIDIISTAPSVIYRFTLDDGVVKTVDNPAHYPDPTFIRMVEEPWVKCHIMIPSEYLGAIMNLGMDKRGVCTKTETMDARRLLLTYRLPLNEIITDFNDKLKSITKGYGSFDYEFDCYEPSEIIKLEIRVNEEPVDAFSCLVHRTKAESKGRAICAKLVEVIPMQLFKVPIQAAIGGKVVARETIRAITKNVTAKCYGGDISRKRKLWEKQKKGKKRMKEIGKVNIPQSAFMEVLKAGD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LOLB_YERPA
Sequence: MPMRKRHFYRLLPLASLLLAACTIPVSKGPATSPTSPQWRQHEQQLQQLGQFETRGAFAYLSDKQKVYARFFWQQTSPERYRLLLTNPLGSTELELVVQPGVTQLTDNQGKRYVSDDPQEMIQKLTGMSIPLESLRQWILGLPGDTSDFTLDDKYRLKKLTYQQNGVTWVVDYQEYNTQVTPSLPSRLELNQDGQRIKLKMDSWTIK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: CHLN_PROM9
Sequence: MSKVELNKETGPREVFCGLTSIVWLHRRMPDAFFLVVGSRTCAHLIQSAAGVMIFAEPRFGTAILEEKDLAGLADAHEELDRVVNDLISRRPEIKTLFLVGSCPSEVIKLDLATVSEKLNKRFLGQVRFVNYSGSGIETTFTQGEDGALKALVPLMESTDDEKLLLVGTLANNVEDRFKKIFNHIGITNVESFPPRQSTELPKIGKNTKVLLTQPYLSDTVRDLKHRGCEIIYAPFPLGVEGSSKWFLAGADAFKINELKVHEVIAPLANRARQALEKHTEILRGKKLFLLPESQLEISLARFLHNECGMELIEVGTPYLNKDLMDEELNLLPDDTKIVEGQHVEKQLDRVRATSPDLVVCGMGLANPLEAEGISTKWSIEMVFSPIHGIDQAADLAGLFSRPLKRNQILTSKTLATH
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
Protein: YIHP_SALTY
Sequence: MSQTSSNPATLRLPFKEKLAYGLGDLGSNILLDIGTLYLLKFYTDVLGLPGTYGGIIFLIAKFFTAFTDMGTGIMLDSRRKIGPKGKFRPFVLYAAFPVTLLAIANFVGTPFEVTGKTVVATMLFMLYGLVFSMMNCSYGAMVPAITKNPDERASLAAWRQGGATLGLLLCTVGFVPVMNLIEGNAQLSYIFAATLFSLFGLLFMWLCYAGVKERYVEVKPVDSAQKPGLLQSFRAIAGNRPLFILCIANLCTLGAFNVKLAIQVYYTQYVLNDPILLSWMGFFSMGCIFIGVFLMPGAVRRFGKKKVYIGGLLIWVAGDLLNYFFGGGSVSFVAFSCLAFFGSAFVNSLNWALVSDTVEYGEWRTGVRSEGTVYTGFTFFRKVSQALAGFFPGWMLTQIGYIPNVVQSAGTVEGLRQLIFIYPCVLAVITIIAMGCFYNLNEKMYVRIVEEIEARKHTV
What is the function of this protein?
Could be involved in the export of 2,3-dihydroxypropane-1-sulfonate (DHPS).
What are the official names of this protein?
Putative 2,3-dihydroxypropane-1-sulfonate exporter.
What is the protein family that this protein belongs to?
Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MLTC_HAES1
Sequence: MKKYIVFAIIPFLFACSSSTLNDDYDEAFAKDTQGLDILTGQFSHNIDQIWGVNELLVASRKDYVKYTDNFYTRSHISFDEGSIMIETLGDKSRLYHSIIHTLLMGADAKGIDLFTSGDVPISSRPFLVGLVVDHKGKQVKNIATASNFANYLLQNKLQTRYLTNGNPVQYVIIPMVANHVAVRAQRYLPLIRKAAGRYGIDESLILGIMQTESSFNPYAISYANAIGLMQVVPHTAGRDVFRLKGLNGQPSKKYLFNPAKNIDTGVAYLTLLRDKYLDGITNPTSKRFAMISAYNSGAGAVLRVFHNDRDIAINKINRLYPEQVYRILTTMHPSEQARNYLLKVDKAQKSYRVIKNSESDLP
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: MNMC_PSEMY
Sequence: MSDAHNAQLDWDEHGQPLSRSYGDVYFSRANGLEETRHVFLAHNQIIERCQALPAGGRLVIGETGFGTGLNFLCAWQAFAEHAPRDARLHFVSVEKFPLTQTDLQRALALWPELAPYAEQLLAQYRAIHPGFQRLLLDGGRVVLTLMIGDVLECLPQLDARIDAWFLDGFAPAKNPEMWTDSLFTELARLSAPGATLATFTSAGFVRRGLIAAGFAVQRVKGFGHKREMLAGPFQAEPAPRSAPWFARPTLAAGARQAVVIGAGLAGCATAASLAARGWRVTLLERHDDVAREASGNPQGVLYLKLSAHGTVLSRLIVAGFGHTRRLLERLQRGSDWDACGVLQLAFDAKEAERQNKLAAAFPDDLLHALPQTEAEARAGIGLPAGGLFYPDAGWVHPPALCRQLAQHPLIELRPYQEALSLSRQQERWCVEGQNGVLAEAPVLILACAAEIGRLLPEANLPLKRIRGQISRLPANESSSALRTVVCAEGYVAPARDDEHTLGASFDFHSDDLTPSVAEHAGNLELLREISQDLAERLDTQTLDPATLQGRAAFRCTSPDYLPLVGPLAAGQAFNQAYAVLAKDARQVPETPCPWLDGLYINSGHGSRGLITAPLSGELIAAWLEDEPLPLPREVAEACHPNRFMLRQLIRGTGSPT
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_LACDB
Sequence: MIKNIGVDQIEVDRIAKVVDRGDGFARKVLTDREFAQYQDLTHKRKIEYLGGRFAIKEAFSKAWGTGIGQAVSFEDVETLRTESGAPVTTSRIFTGRIFSSIAHDDHEIVAVVVLEEPAGWRRAIGKLSHLLSGRKK
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_HAEIE
Sequence: MNLNATLIGQLIAFALFVWFCMKFVWPPIINAIETRQSQIANALASAEAAKKEQADTKNLVEQELSAAKVQAQDILDAANKRRNEVLDEVKAEAEELKAKIIAQGYAEVEAERKRVQEELRLKVASLAVAGAEKIVGRSIDEAANNDIIDKLVAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TC132_ARATH
Sequence: MGDGTEFVVRSDREDKKLAEDRISDEQVVKNELVRSDEVRDDNEDEVFEEAIGSENDEQEEEEDPKRELFESDDLPLVETLKSSMVEHEVEDFEEAVGDLDETSSNEGGVKDFTAVGESHGAGEAEFDVLATKMNGDKGEGGGGGSYDKVESSLDVVDTTENATSTNTNGSNLAAEHVGIENGKTHSFLGNGIASPKNKEVVAEVIPKDDGIEEPWNDGIEVDNWEERVDGIQTEQEVEEGEGTTENQFEKRTEEEVVEGEGTSKNLFEKQTEQDVVEGEGTSKDLFENGSVCMDSESEAERNGETGAAYTSNIVTNASGDNEVSSAVTSSPLEESSSGEKGETEGDSTCLKPEQHLASSPHSYPESTEVHSNSGSPGVTSREHKPVQSANGGHDVQSPQPNKELEKQQSSRVHVDPEITENSHVETEPEVVSSVSPTESRSNPAALPPARPAGLGRASPLLEPASRAPQQSRVNGNGSHNQFQQAEDSTTTEADEHDETREKLQLIRVKFLRLAHRLGQTPHNVVVAQVLYRLGLAEQLRGRNGSRVGAFSFDRASAMAEQLEAAGQDPLDFSCTIMVLGKSGVGKSATINSIFDEVKFCTDAFQMGTKRVQDVEGLVQGIKVRVIDTPGLLPSWSDQAKNEKILNSVKAFIKKNPPDIVLYLDRLDMQSRDSGDMPLLRTISDVFGPSIWFNAIVGLTHAASVPPDGPNGTASSYDMFVTQRSHVIQQAIRQAAGDMRLMNPVSLVENHSACRTNRAGQRVLPNGQVWKPHLLLLSFASKILAEANALLKLQDNIPGRPFAARSKAPPLPFLLSSLLQSRPQPKLPEQQYGDEEDEDDLEESSDSDEESEYDQLPPFKSLTKAQMATLSKSQKKQYLDEMEYREKLLMKKQMKEERKRRKMFKKFAAEIKDLPDGYSENVEEESGGPASVPVPMPDLSLPASFDSDNPTHRYRYLDSSNQWLVRPVLETHGWDHDIGYEGVNAERLFVVKEKIPISVSGQVTKDKKDANVQLEMASSVKHGEGKSTSLGFDMQTVGKELAYTLRSETRFNNFRRNKAAAGLSVTHLGDSVSAGLKVEDKFIASKWFRIVMSGGAMTSRGDFAYGGTLEAQLRDKDYPLGRFLTTLGLSVMDWHGDLAIGGNIQSQVPIGRSSNLIARANLNNRGAGQVSVRVNSSEQLQLAMVAIVPLFKKLLSYYYPQTQYGQ
What is the function of this protein?
GTPase involved in protein precursor import into chloroplasts.  Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis.  Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast.
What are the official names of this protein?
Translocase of chloroplast 132, chloroplastic, AtToc132, 132 kDa chloroplast outer envelope protein.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. TOC159 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane; Single-pass membrane protein. Cytoplasm. Note=Cycles between the cytoplasm and chloroplast, probably as a soluble preprotein receptor. The anchoring to the chloroplast outer membrane required the GTPase activity and GDP. May contain beta barrel transmembrane regions (By similarity).
Protein: RFOX2_MOUSE
Sequence: MAEGGQAQQQPPQLGPGAAARGMKRESEVELPVPGAGADGPEPGLSKRPRTEEAADGGMQNEPLTPGYHGFPARDGQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQPHGEQSSNSPSNQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNEAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY
What is the function of this protein?
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements.  Prevents binding of U2AF2 to the 3'-splice site.  Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.  Seems to act as a coregulatory factor of ER-alpha (By similarity).
What are the official names of this protein?
RNA binding protein fox-1 homolog 2, Fox-1 homolog B, Fox-1 homolog Fxh, Hexaribonucleotide-binding protein 2, RNA-binding motif protein 9, RNA-binding protein 9.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ILID_NEOS2
Sequence: MTSTEAAGTGKAPAIRANPALQTYYESQESYLVYEVVLRGSHHFGFYEKDTYWPFPVGRSLERMEAKLLSALALPSGSQILDAGCGFGPVAISMAKKGMRVTAIDIIDHHVTKARRNVEKAGLPKGQVTVEKMDYQHLESIASESHDDAKAAATGFFRILKPGGRIAFFEAQRSRTSGDYDEGDELAGHLKLVNEYTAMPTNELSREDYFKDLLEDAGFVDVEFTLPPGTREPREHWSYSALKA
What is the function of this protein?
S-adenosyl-l-methionine-dependent Diels-Alderase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:31216742).  IliD catalyzes the Diels-Alder reaction that converts the acyclic 2-pyridone intermediate to 8-epi-ilicicolin H (PubMed:31216742).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (PubMed:31216742) (Probable).
What are the official names of this protein?
S-adenosyl-L-methionine-dependent Diels-Alderase iliD, C-methyltransferase iliD, Ilicicolin H biosynthesis cluster protein D, Pericyclase iliD.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
Protein: TGFB1_XENLA
Sequence: MEVLWMLLVLLVLHLSSLAMSLSTCKAVDMEEVRKRRIEAIRGQILSKLKLDKTPDVDSEKMTVPSEAIFLYNSTLEVIREKATREEEHVGHDQNIQDYYAKQVYRFESITELEDHEFKFKFNASHVRENVGMNSLLHHAELRMYKKQTDKNMDQRMELFWKYQENGTTHSRYLESKYITPVTDDEWMSFDVTKTVNEWLKRAEENEQFGLQPACKCPTPQAKDIDIEGFPALRGDLASLSSKENTKPYLMITSMPAERIDTVTSSRKKRGVGQEYCFGNNGPNCCVKPLYINFRKDLGWKWIHEPKGYEANYCLGNCPYIWSMDTQYSKVLSLYNQNNPGASISPCCVPDVLEPLPIIYYVGRTAKVEQLSNMVVRSCNCS
What is the function of this protein?
Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity).  Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix.  At the same time, LAP chain interacts with 'milieu molecules', such as ltbp1, lrrc32/garp and lrrc33/nrros that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus.  TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1.  Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (tgfbr1 and tgfbr2), which transduce signal (By similarity).  While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'.  Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation.  Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner (By similarity).  Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).
What are the official names of this protein?
Transforming growth factor beta-1 proprotein, TGF-beta-5.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix. SUBCELLULAR LOCATION: [Transforming growth factor beta-1]: Secreted.
Protein: RL19_POLNA
Sequence: MNLIQTLEQEEIARLNKTIPVYAPGDTVIVSVNVVEGTRKRLQAFEGVVIAKRNRGLNSSFIVRKISNGEGVERTFQVYSPLIAKIEVKRKGDVRRAKLYYLRSRSGKSARIKEKLGVKAVKAVQPVQAA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: UNG_ACTP2
Sequence: MNNWTEALGEEKQQPYFQHILQQVHQERMNGVTVFPPQKEVFSAFALTEFKDVKVVILGQDPYHGPNQAHGLAFSVKPPVAPPPSLVNMYKELAQDVEGFQIPNHGYLVDWAKQGVLLLNTVLTVRQGQAHSHANFGWEIFTDKVIAQLNQHRENLVFLLWGSHAQKKGQFIDRSRHCVLTAPHPSPLSAYRGFFGCKHFSKTNRYLLSKGIAPINWQLRLEIDY
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y733_STAAE
Sequence: MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein NWMN_0733.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: HIS7_CLOK5
Sequence: MRIGEISRKTYETDIEVKIDLDGRGKYNIDTGIGFFNHMLCMIAKHGIMDMDVYAKGDLDVDFHHTVEDVGICIGKSIKKALGNKKSIKRYGTFFIPMDESLSMCSVDLSGRPFLVFQGELKNSKVGEMDTELIEEFFRALAFNAEMTLHIKVFYGKNTHHIIESVFKSFAHALREAVSIDEKIEGTMSTKGMI
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_RICPU
Sequence: MARITAEDCNKIIPDRFRLVVLATRYAKLLNYKVETNQIKKEKRDKPPVIALRRIAAGKVSVAQLEQDLINSLRTRTMIEPLVNQDESEAVEEKFEYLSEVYIGEDYSDLDDQIFIDENGEDYETDK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: SYDND_PROM0
Sequence: MRNKICKELNNTDIGKLVNLCGWVDRRRDHGGVIFIDLRDHSGFLQITINPDDGAALFKQAETLRNETVIMVSGIINERPKDSINTNLSTGELELKVKDLQILNQIKKNLPFPVSIHDYENTKEELRLKYRYLDLRRGKLLENLKTRHKIIKVAREFLDNFGFTEVETPLLTKSTPEGARDFLVPARLSNGEFFALPQSPQLFKQLLMVGGLDKYYQIAKCFRDEDLRADRQPEFTQLDIEMSFISEEEIISFNESLIKKIWKEVLNIKFNNAFPRMSWQEAMDNYGTDRPDTRYQMLLKDLGGILGDIGFNIFTKAIKSGGYIKSITVKGGNSSISNVRIKPGGDIFQVAKDAGAGGLAFIRVKGDELETIGAIKNNLSEEHIADILKITEAKDGDLILLGAGDKLIVNQSLDRVRQYIAKDLNLIDKSKWNFLWVTDFPMFERNEEENRYEALHHPFCSPKNIKSKDSENLKKEIESSTANAYDLVLNGLELGGGSLRIHEANLQREVLKMVGLTDKEIDEKFGFLIEALEMGAPPHGGIAFGLDRITMLIIGTDSIRETIAFPKNQQAKCLLTNAPSNVSESQLKELDIEITIDE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSA_SYNFM
Sequence: MAGNIFPVPESWAKSAFCDNETYLKMYEQSVKDPEGFWGEHAKRIDWFQPWTKVKSGSFEGDVRFKWFENGKLNVAYNCLDRNLAKRGDQVAIIWEGDDPKVSKYITYRELHDQVCRFANVLKAQGLKKGDRATIYLPMIPELAVAMLACARIGVVHSIVFAGFSPESLAGRILDCGGKVVITADEGLRGGKPIPLKENTEEALKKCPDVQKVIVVKHTGGKVPVVPGRDVDWTEAIKAASPDCPPEVMDAEDPLFILYTSGSTGKPKGVLHTTGGYLVYTALSHQYVFDYHDGDIYWCTADIGWVTGHSYIIYGPLANGATTVMFEGIPNYPDWSRFWNVVDKHKINIFYTAPTAIRALMRQGEAPVRATSRKSLKLLGTVGEPINPEAWLWYYNNVGEQRCPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPAIIDPEGKMLDGPGSGYLIIKESWPGMLRTVYGDHERFKQTYFSNYPGLYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHPAVAESAVVGFPHDIKGQGIYAYVTLKANWEHSDELRQELVKWVRKEIGPIATPDYIQWAPGLPKTRSGKIMRRILRKIAANEIDNLGDTTTLAEPAVVEDLIKNRQAVASSGKA
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: RS17_ACIBC
Sequence: MSEKTVRTLTGKVVSDKMDKSIVVLIERRVQHPLYGKSIRRSTKLHAHDENNVAKIGDVVTIKESRPISKTKAWTLVEVVEAAAE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.