PharMolix/UniProtQA huggingface dataset:
Protein: TETX_CLOTE
Sequence: MPITINNFRYSDPVNNDTIIMMEPPYCKGLDIYYKAFKITDRIWIVPERYEFGTKPEDFNPPSSLIEGASEYYDPNYLRTDSDKDRFLQTMVKLFNRIKNNVAGEALLDKIINAIPYLGNSYSLLDKFDTNSNSVSFNLLEQDPSGATTKSAMLTNLIIFGPGPVLNKNEVRGIVLRVDNKNYFPCRDGFGSIMQMAFCPEYVPTFDNVIENITSLTIGKSKYFQDPALLLMHELIHVLHGLYGMQVSSHEIIPSKQEIYMQHTYPISAEELFTFGGQDANLISIDIKNDLYEKTLNDYKAIANKLSQVTSCNDPNIDIDSYKQIYQQKYQFDKDSNGQYIVNEDKFQILYNSIMYGFTEIELGKKFNIKTRLSYFSMNHDPVKIPNLLDDTIYNDTEGFNIESKDLKSEYKGQNMRVNTNAFRNVDGSGLVSKLIGLCKKIIPPTNIRENLYNRTASLTDLGGELCIKIKNEDLTFIAEKNSFSEEPFQDEIVSYNTKNKPLNFNYSLDKIIVDYNLQSKITLPNDRTTPVTKGIPYAPEYKSNAASTIEIHNIDDNTIYQYLYAQKSPTTLQRITMTNSVDDALINSTKIYSYFPSVISKVNQGAQGILFLQWVRDIIDDFTNESSQKTTIDKISDVSTIVPYIGPALNIVKQGYEGNFIGALETTGVVLLLEYIPEITLPVIAALSIAESSTQKEKIIKTIDNFLEKRYEKWIEVYKLVKAKWLGTVNTQFQKRSYQMYRSLEYQVDAIKKIIDYEYKIYSGPDKEQIADEINNLKNKLEEKANKAMININIFMRESSRSFLVNQMINEAKKQLLEFDTQSKNILMQYIKANSKFIGITELKKLESKINKVFSTPIPFSYSKNLDCWVDNEEDIDVILKKSTILNLDINNDIISDISGFNSSVITYPDAQLVPGINGKAIHLVNNESSEVIVHKAMDIEYNDMFNNFTVSFWLRVPKVSASHLEQYGTNEYSIISSMKKHSLSIGSGWSVSLKGNNLIWTLKDSAGEVRQITFRDLPDKFNAYLANKWVFITITNDRLSSANLYINGVLMGSAEITGLGAIREDNNITLKLDRCNNNNQYVSIDKFRIFCKALNPKEIEKLYTSYLSITFLRDFWGNPLRYDTEYYLIPVASSSKDVQLKNITDYMYLTNAPSYTNGKLNIYYRRLYNGLKFIIKRYTPNNEIDSFVKSGDFIKLYVSYNNNEHIVGYPKDGNAFNNLDRILRVGYNAPGIPLYKKMEAVKLRDLKTYSVQLKLYDDKNASLGLVGTHNGQIGNDPNRDILIASNWYFNHLKDKILGCDWYFVPTDEGWTND
What is the function of this protein?
Tetanus toxin acts by inhibiting neurotransmitter release.  It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons.  It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
What are the official names of this protein?
Tetanus toxin, Tentoxylysin.
What is the protein family that this protein belongs to?
Belongs to the peptidase M27 family.
Protein: HBA_VIPAS
Sequence: VLSEDDKNRVRTSVGKNPELPGEYGSETLTRMFAAHPTTKTYFPHFDLSSGSPNLKAHGKKVIDALDNAVEGLDDAVATLSKLSDLHAQKLRVDPANFKILSQCLLSTLANHRNPEFGPAVLASVDKFLCNVSEVLESKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: TRUA_BDEBA
Sequence: MTTKVRFTVAYDGTGFCGWQKQKPEDQISVAQVIEEALSKVFNEKITLFASGRTDAGVHALNQVCHFSTHRKIDPNKKWDLCWALNSHLPPSIVAKKAWIAPDDFHATLSATHKTYRYLIVNKPRPSAHLNRYADWVRLPIDIEHLQESSKYLLGNQDFKSFQSVGTPVPDTVREIYKADWEWRKPGVMQFTITGSGFLKQMVRNIVGTSLFLERKGLDPSKMQEIIAAQDRMKAGPPAPAQGLYLMKVYYPQDLDNRCLEL
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: GCSPB_PYRAB
Sequence: MYRQAKWDEPLIFELSRPGRVGYTLPKPIEDVDVEIPEKLKRKSPLNLPEVSEPEVVKHYTRLSEMNYGVDSGIYPLGSCTMKYNPKINEELAGHPKVAYIHPYQDERTVQGALRIMWELEQWLKEITGMDRFTLQPAAGANGEFTGVMIIKAYHLDRGETQRNEMLVPDSAHGTNPASAAMAGFKVIEIPSNENGTVDLEALENAVSERTAGLMLTNPNTLGIFEDEIEEIAKIVHKAGGLLYYDGANLNGILGKVRPGDMGFDIVHLNLHKTFSTPHGGGGPGAGPVGVKEFLKDYLPVPLVSYDEENDRYYLDYDVPKSIGKVKELFGNFAVLVRALTYLKVMGKDGLREVSEVAVLNANYLARKLKGTRGYELPHKELRKHEVVFSAEPMKRETGVRTLDVAKRLLDFGMHAPTIYFPLIVHEALMIEPTETVSKEELDAYVEAMKKISEEAYTNPEVVKSAPHNTAVRRVDDVLASKKPIITWKMYKELKEKGEVDY
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: IF2P_HALMA
Sequence: MSDTDPTTATDDTLRTPIVAVLGHVDHGKTSLLDKIRGSAVTAGESGAITQHIGATAVPLDVISEIAGDLVDPTDFDLPGLLFIDTPGHHSFSTLRSRGGALADIAILVVDVNDGFQPQTLEAIDILKRTQTPFIVAANKIDTVPGWNPNEGQPVQQTMDAQSDRVQSDLNEKLYEIIGELSDNGFSADMYWRVQNFQANIGVVPVSAETSEGIPDLLTVMMGLSQRYMKEEMEIDTSGPGVGTVLEVKDTQGFGTTLDAIIYDGTIRNDDTIVVGGLQGPIITDVRALLRPRPLEEIRTEQEFEQVDEVAAADGVKIAAPELGDAMAGAPIRVIRDRDRSEVIAEVEEELAEIEVTTQEEGVVIKADTLGSLEALSSTLEEEEIPVMRAEVGAVAPRDVRVAETAGESTNQAILAFSVDVLDDARDLAEQEDVKLFEDDVIYQLVESYDDHVTAIEEAQQEQILENITRPAKFRILQDHTFRQSDPAVVGVEILSGELRRNVNVVRWENGEANRVGTLKTIQDEGEDVDSARAGERMAVSIQGPTVGRQVEEGDDLWVEIPEKHAKILEQELKEDISVDEREALSMYLEKHRNRDPFWGK
What is the function of this protein?
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes.  Seems to function along with eIF-2.
What are the official names of this protein?
Probable translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Protein: SPT6_ASHGO
Sequence: MSSEGLASARELEERDLGATRDTEEIPSDEEEGEDVFDSSEEDEDLDEDEEEARKVKEGFIVSDDEEDDSSVKQRRRRKHKRRPRHEEDDGKLSEDDLDLLMENAGVKRTTRPETDATKGRFKRLKRAGSPDESEGQQDTDGRHENRLEDFFSEEEDEEHLGGTENRRLRTGGKDVLDELDDFIEEDEFSDEDEATRQQRRKLKEQRSKQSVQITGLSSDKIDEMYDIFGDGHDYDWALAVENEDDLENLDEYQQEEDDDETSDQKAKKKKITLQDIYDMQDLKKNLMTEEDMVIRRSDIPERYQELRAGLKNYGQLTPEDQLLEQNWISDKIAVDKNFDATYDISEFREAVGDAVRFISKENLEVSFIYAYRRNYISSRDKNGFILSEDDLWDIVFYDIEFHSIIYKRDYVKKFYEQLGIRDSLVDDYFNDESMTELNSLQDIYNYLEFRYAHEINDALLADSSSKTKKHLKNSSYEKFKSSSLYQAVKDVGITAEQIGENIGAETQIHPVVDHPNLKPSESISQILDAASADLQVFAKNHKLAWDTVQKYFAAEIGNNPKVRQKIRNDFYKYYIVDVVLTTKGRKEIQRSSPYEDIKYAINRTPGHFRSAPDVFLRMLEAESLHLMNIKIHMSSQEQYCEHLFQIALETTNTSEIAIEWNNFRRNAFYQALEKIFEDIAQEIKDELKKTSQKLVANSVRHRFMSKLDQAPFIPNPREPKIPRVLTITCGQGRFGLDAIIAVLLNRKGDFVKDFKIVQNPFDRDQPQAFEAVLDNIIQEAQPNVIGINGPNPKTQKLFKKIQEVIQKKQIVDNRGHNIPVIFVEDEIAIRYQSSERGAQEFPNKPTLVKYCIALARYIHSPLLEYTNLSEEELQSLLIHPHQSLLPRHIFKRALETSFVDIVNLVGVEVNKANDNPYYAKALQYIAGLGKRKAIDFLESLQRLNEPLLARQQLITHDILHKTIFMNSAGFLYISWNEKNQRYEDLEHDHLDSTRIHPEDYHLATKVAADALEYDPDAIREKEEQGAMSEFIELLRDDPDRRMKLESLNLEEYADELERSTGQRKLNNLNTIVLELLEGFEELRNDFHPLQGDEIFTSLTGETDKTFFKGSIIPVRVERFKHNDIICISNSQVECIVNAQRHLGVQLKRPASDIYEVGKTYPAKIIFIDYENISAEVSLLDHDVKHQYIPVDYSKDPTIWNLKQELEDVEEEKKISMAEARAKRTHRVINHPYYFPFNGKQAEDYLRSKERGEFIIRQSSRGDDHLAITWKLDKDLFQHVDILELDKENPLALGKTLIVDNNKYNDLDHVIVEYLQNKIKLLNEITSNEKFKKGTKKEVVKFIEDYSNVNPNRSVYYLSFNYEHPGWFYLMFKINAQSKLCTWNVKLTHNGFSLADYNYPTVIQLCNGFKTLLKSSSRARTQEASGSGYYGY
What is the function of this protein?
Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters.  Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).
What are the official names of this protein?
Transcription elongation factor SPT6, Chromatin elongation factor SPT6.
What is the protein family that this protein belongs to?
Belongs to the SPT6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GEML4_ARATH
Sequence: MNMSRVEQQVIRYPAAKATPVGYLPDPASFNKFRVPASSKKSEQSNVKSILKRKKTDGFTNGVRDQSKIRPKLTETVKRKLSLGARILQVGGLEKIFKRLFRVSEGEKLFKMYQCYLSTTAGPIAGLLFISSKKMAFCSERSIKVDSPQGDIIRVHYKVSIPLCKIDRVNQSQNTKKPSQKYLEVVTVDGFDFWFMGFLSYQKAFNCLEKALSLSFEDNKEQ
What are the official names of this protein?
GEM-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the GEM family.
Protein: Y1852_STAAW
Sequence: MSFVTENPWLMVLTIFIINVCYVTFLTMRTILTLKGYRYIAASVSFLEVLVYIVGLGLVMSNLDHIQNIIAYAFGFSIGIIVGMKIEEKLALGYTVVNVTSAEYELDLPNELRNLGYGVTHYAAFGRDGSRMVMQILTPRKYERKLMDTIKNLDPKAFIIAYEPRNIHGGFWTKGIRRRKLKDYEPEELESVVEHEIQSK
What are the official names of this protein?
UPF0316 protein MW1852.
What is the protein family that this protein belongs to?
Belongs to the UPF0316 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1127_METJA
Sequence: MDVLKSLPVTDNHIHVDDKHGYGAEKVAKTFYNAGGKVMIVLNKPTFDGNLTASMDILVRDVEIINKNTPVKAFGLVGVHPAELTYLMKFMSLEEAKQRIVDALNYAKKLVEEYDFIVGIGEVGRPHYPVSEDVWKASNEILKYCMELAKDIGCAIQIHAESSTEEQFKEFSEMAKEVGLNPEKVVKHHCGNMVLEGERYGIFPSILASRVNEDVVKKSLRFVMETDYIDDLKRPGVALGIKTVPRVTRRLIEKGVLDEEGVYKIHKENIERIYDMDLEL
What are the official names of this protein?
Uncharacterized protein MJ1127.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily.
Protein: CDPKB_ORYSJ
Sequence: MGNNCVGPSAAGQNGFFANVALWRPRPADAAPPALPPPSSAPSDQAPEPVTIPPSEHSSHHSSRSTDPSTPTSAAEQPANKAAPKVKRVQSAGLLADSVLKRDVNTARLKDLYTIGKKLGQGQFGTTYLCVEKATGREFACKSIAKRKLLTQEDVEDVRREIQIMHHLAGHANVVSIVGAYEDAVAVQLVMELCAGGELFDRIIQRGHYSEKAAAQLARVIVGVIEACHSLGVMHRDLKPENFLFIHQKEDSPLKAIDFGLSIFFKPGETFTDVVGSPYYVAPEVLMKHYGREVDVWSAGVIIYILLSGVPPFWDESEQGIFEQVLKGDLDFSSEPWPNISESAKDLVRKMLIRDPKKRLTAHEALCHPWVCVDGVAPDKPLDSAVLSRLKQFSAMNKLKKMALRVIAESLSEEEIAGLKEMFKMLDTDNSGHITLEELKTGLQRVGANLMDSEIDALMEAADIDNSGTIDYGEFIAATLHINKVEKEDKLFAAFSYFDKDGSGYITQDELQKACEEFGIGDTRIEDIIGDIDQDNDGRIDYNEFVEMMQKGNNAMGKMGQHSTGNFGLGEALKLR
What is the function of this protein?
May play a role in signal transduction pathways that involve calcium as a second messenger.
What are the official names of this protein?
Calcium-dependent protein kinase 11, OsCDPK11, OsCPK11.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor.
Protein: EX7S_CITBB
Sequence: MAVEKFETALKKLEDVVKKLEGGELSLEESLKAFEEGVKFSAFCSKKLNEAERRVETLVKQRDGSFVTKPFEEEE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLD3_HUMAN
Sequence: MKPKLMYQELKVPAEEPANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTGNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLRQLQTLAPKGVNVRIAVSKPSGPQPQADLQALLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGGLRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL
What is the function of this protein?
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed:30312375).  Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity).  May be important in myotube formation (PubMed:22428023).  Plays a role in lysosomal homeostasis (PubMed:28128235).  Involved in the regulation of endosomal protein sorting (PubMed:29368044).
What are the official names of this protein?
5'-3' exonuclease PLD3, Choline phosphatase 3, HindIII K4L homolog, Hu-K4, Phosphatidylcholine-hydrolyzing phospholipase D3, Phospholipase D3, PLD 3.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family.
Protein: NADK_BLOPB
Sequence: MTSSIFRTIGIIGYSRHPKAVHTYDILYHWLYSKGITVIIEHHAASLLNVQKAVVGDLNDIGNYADLAIVIGGDGNMLRAANILAQHDIKVIGINRGTLGFLTDLDPNSALVELSDVLSGHFINEKRFLLDVTVQRYNKLIRLGSAINEVILHTNTIRDMIEFELYIDDNFIFSQRSDGLIISTPTGSTAYALSAGGPILSPTVDAILLVPICPHTLSSRPVVINSKSIICLKFSKVTSELKIGYDNQTPVLVCKEEEIFIKRSNHYLDLIHPNNYNYFKTLNIKLGWSQNIAETKK
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHAN2_HUMAN
Sequence: MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPPPSPTTYNCPKSPTPRVYGTIKPAFNQNSAAKVSPATRSDTVATMMREKGMYFRRELDRYSLDSEDLYSRNAGPQANFRNKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAAAIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQLSSPMPSATPREPENHFVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGNYVHPLTGRLLDPSSPLALALSARDRAMKESQQGPKGEAPKADLNKPLYIDTKMRPSLDAGFPTVTRQNTRGPLRRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVDATKLDNALQEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGSMEEAVILPFRIPPPPLASVDLDEDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQKKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSSDHHLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSNALYQDALVEEDVDSFVIPPPAPPPPPGSAQPGMAKVLQPRTSKLWGDVTEIKSPILSGPKANVISELNSILQQMNREKLAKPGEGLDSPMGAKSASLAPRSPEIMSTISGTRSTTVTFTVRPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLPAPLSAATASPSPALSDVFSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR
What is the function of this protein?
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton.  May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
What are the official names of this protein?
SH3 and multiple ankyrin repeat domains protein 2, Shank2, Cortactin-binding protein 1, CortBP1, Proline-rich synapse-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the SHANK family.
What are the subcellular locations of this protein?
Apical cell membrane. Cytoplasm. Synapse. Postsynaptic density. Cell projection, growth cone. Cell projection, dendritic spine. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity).
Protein: CCA_METTH
Sequence: MTTDYSNILKTIKPDGDEYRRVMELSDSLVECLNGLAEEQGIDAEAVLVGSVAKGTWLSGAADIDIFIHFPLTTPEDELKESGLRLGYGCIERFGGEAEERYASHPYVTGYIDGYEVDFVPCYRIDDASMLRSAVDRTILHTRYIQENLRDEQRDDVLLLKQFMKSTGTYGSEFRVGGFAGYLAELLVLRYGDFEGVLEGALQWRPGYIIDLEGHGTGKGFEDPLVVVDPVDRNRNVAAALTLQRMAEFVTASLNFLGNPSPEYFQPPSYSTDAAEITGTLSCRGSRVIVISTGVPDVPSDALYPQLRKTLDSVVKNLEAEGFSVLGADYWSDESKSTFMVLEMDVWELPSYLKRYGPPVWSRRHRERFLRKHERVWVEGSRLTIESPRRHRSAVSYLRDLLSKPDRLRMGKHIGVEIRRGFSVDLLDDVIGEAEKEFLEFMDAFLNPWKALER
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
Protein: SDRC_STAAN
Sequence: MNNKKTATNRKGMIPNRLNKFSIRKYSVGTASILVGTTLIFGLSGHEAKAAEHTNGELNQSKNETTAPSENKTTEKVDSRQLKDNTQTATADQPKVTMSDSATVKETSSNMQSPQNATASQSTTQTSNVTTNDKSSTTYSNETDKSNLTQAKNVSTTPKTTTIKQRALNRMAVNTVAAPQQGTNVNDKVHFTNIDIAIDKGHVNKTTGNTEFWATSSDVLKLKANYTIDDSVKEGDTFTFKYGQYFRPGSVRLPSQTQNLYNAQGNIIAKGIYDSKTNTTTYTFTNYVDQYTNVSGSFEQVAFAKRENATTDKTAYKMEVTLGNDTYSKDVIVDYGNQKGQQLISSTNYINNEDLSRNMTVYVNQPKKTYTKETFVTNLTGYKFNPDAKNFKIYEVTDQNQFVDSFTPDTSKLKDVTGQFDVIYSNDNKTATVDLLNGQSSSDKQYIIQQVAYPDNSSTDNGKIDYTLETQNGKSSWSNSYSNVNGSSTANGDQKKYNLGDYVWEDTNKDGKQDANEKGIKGVYVILKDSNGKELDRTTTDENGKYQFTGLSNGTYSVEFSTPAGYTPTTANAGTDDAVDSDGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKGVKVTLQNEKGEVIGTTETDENGKYRFDNLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDNDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPTKPMSTVKDQHKTAKALPETGSENNNSNNGTLFGGLFAALGSLLLFGRRKKQNK
What is the function of this protein?
Cell surface-associated calcium-binding protein which plays an important role in adhesion and pathogenesis.  Mediates interactions with components of the extracellular matrix such as host NRXN1 to promote bacterial adhesion.
What are the official names of this protein?
Serine-aspartate repeat-containing protein C.
What is the protein family that this protein belongs to?
Belongs to the serine-aspartate repeat-containing protein (SDr) family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor.
Protein: PDK1_YEAST
Sequence: MWKIMRSWKCGGMRWAHRQRPSHELLSQLSFDQHYKIRSNIELLIQDYASKPIAPLNYEYFLQYRPPLTKKEEYMLTIKTINLLLSLTCKRLNAIQRLPYNAVINPHIERTNSLYLKSLQTLLSIAYPYELHNPPKIQAKFTELLDDHEDAIVVLAKGLQEIQSCYPKFQISQFLNFHLKERITMKLLVTHYLSLMAQNKGDTNKRMIGILHRDLPIAQLIKHVSDYVNDICFVKFNTQRTPVLIHPPSQDITFTCIPPILEYIMTEVFKNAFEAQIALGKEHMPIEINLLKPDDDELYLRIRDHGGGITPEVEALMFNYSYSTHTQQSADSESTDLPGEQINNVSGMGFGLPMCKTYLELFGGKIDVQSLLGWGTDVYIKLKGPSKTALLSKK
What is the function of this protein?
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism.  Also involved in telomere maintenance.
What are the official names of this protein?
[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial, PDK 1, Pyruvate dehydrogenase kinase 1, Protein kinase of PDH protein 1, Pyruvate dehydrogenase complex kinase 1, PDC kinase 1, [Pyruvate dehydrogenase [lipoamide]] kinase 1.
What is the protein family that this protein belongs to?
Belongs to the PDK/BCKDK protein kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GPA1_KLULA
Sequence: MGCVASTGNYENEDDPFIQNKRANDLIEQNLQQERNKNKNEVKLLLLGAGESGKSTVLKQMKLLHQGGFTHRERMQYGQVIWADAIESMRTLILQAGKLGIELDSDLKNAHSGQLVNTELHQCKEKIFRANTLDQIDARMAGGSEFLNEYVLKYNGIGSKKKRQTTLGFKESNGADPEEEDETDAFLSEKLAGTSYTGSSETSELKRIDQSTNEEIAYAIKKLWTQDKGIRQCFNRSSEFQLEGSASYYFDNIEKFARVDYVCDDMDILKGRIKTTGITENSFKIGPSTFKVYDAGGQRSERRKWIHCFEGITAVVFVIAISEYDQMLFEDERVNRMHESIVLLDTLLNSRWFANTPFILFLNKVDIFQEKVKRSPIRTWFPNYPGKLGDSETGLKYFESLFLSLNRSNKPIYVHRTCATDTQSMRFVLGAVTDLVIQQNLKKSGIL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  This protein is involved in the mating response pathway.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-1 subunit, GP1-alpha.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: RR14_LOBMA
Sequence: MAKKSLIYREKKRQKLEQQYHLIRRSSKKEISQIPSLSEKWKIHGKLQSPPRNSAPTRLHRRCFSTGRPRANYRDFGLSGHILREMVHAGLLPGATRSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LYSM1_RAT
Sequence: MASPSRQPPLGGSGLLRGSRARSYGSLVQSSCSPVRERRLEHQLEPGDTLAGLALKYGVTMEQIKRTNRLYTNDSIFLKKTLYIPILTEPRDLFNGLDSEEEENDGEEEVRPSKDEIGSSSGKRKNQGSASSQPKGTGLPPHQGTSTPSHDLSASDFLKKLDSQISLSKKAAAQKLRKGESGVPEEDTGLYPSSPRMQQRAVLGPVPLTRTSRTQTLRDQEDEIFKL
What are the official names of this protein?
LysM and putative peptidoglycan-binding domain-containing protein 1.
Protein: PHAR1_RAT
Sequence: MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEDDSLTNGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVLICMPVGGPELSLASYAAQKSSQQAVAQHHHTVLPSQMQHQLQYGSHGQHLPSSTGTLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSSDGVTKAGPLGLPEIRQVPTVVIECDDNKENVPHEPDYEDSSCLYAREEEEEEEDEDDDASLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP
What is the function of this protein?
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (By similarity).  Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).
What are the official names of this protein?
Phosphatase and actin regulator 1.
What is the protein family that this protein belongs to?
Belongs to the phosphatase and actin regulator family.
What are the subcellular locations of this protein?
Cytoplasm. Synapse. Nucleus. Note=Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity). Enriched at synapses.
Protein: EBRA_BACAT
Sequence: MLVGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIAYSLAFYMLSLTLNHIPLSLSYATWSGVGTVLTAVIGVKWFKEELNAKGLIGILLLISGVVLLNWQ
What is the function of this protein?
Part of a multidrug efflux pump.  Confers resistance to cationic lipophilic dyes such as ethidium bromide, acriflavine, pyronine Y and safranin O.  The efflux is probably coupled to an influx of protons.
What are the official names of this protein?
Multidrug resistance protein EbrA.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. EbrA/EbrB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UBIG_PSEFS
Sequence: MSNVDHAEIAKFEALAHRWWDRESEFKPLHDINPLRVNWIDERVNLAGKKVLDVGCGGGILSEAMAQRGATVMGIDMGEAPLAVAQLHQLESGVSVEYRQITAEALAEEMPEQFDVVTCLEMLEHVPDPSSVIRACFRMVKPGGQVFFSTINRNPKAYLFAIIGAEYIMKLLPRGTHDFKKFIRPSELGAWSRQAGLTVKDIIGLTYNPLTKHYKLASDVDVNYMIQTLREE
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.