PharMolix/UniProtQA huggingface dataset:
Protein: FLGI_SINMW
Sequence: MKMRACKWLLTLAVAFAATLSSAYAASRIKDVASLQAGRDNQLIGYGLVVGLQGTGDSLRSSPFTDQSIRAMLQNLGISTQGGDSRTRNVAAVLVTATLPPFASPGSRLDVTVGSLGDATSLRGGTLVMTSLSGADGQIYAVAQGSVVVSGFNAQGEAAQLNQGVTTAGRVPNGAIIERELPSKFKDGFNLVLQLRNPDFSTAVGMAAAINRYAAAQFGGRIAEALDSQSVLVQKPKMADLARLMADVENLVIETDAPARVVINERTGTIVIGQDVRVAQVAVSYGTLTVQVSETPTIVQPEPFSRGQTAYEPNTTIEAQSDGGTVAILNGSSLRSLVAGLNSIGVKPDGIIAILQSIKSAGALQAELVLQ
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: NU6C_ORYSA
Sequence: MDLPGPIHEILVLFGGFVLLLGGLGVVLLTNPTFSAFSLGLVLVCISLFYILLNSYFVAVAQLLIYVGAINVLIIFAVMFVNGSEWSKDKNFWTIGDGFTSLVCITIPFSLMTTIPDTSWYGILWTTRSNQIVEQGLINNVQQIGIHLATDFYLPFELISIILLVSLIGAITMARQ
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y2339_MYCBO
Sequence: MMKEIELHLVDAAAPSGEIAIKDLAALATALQELTTRISRDPINTPGPGRTKQFMEELSQLASAPGPDIDGGIDLTDDEFQAFLQAARS
What are the official names of this protein?
Uncharacterized protein Mb2339.
Protein: Y327_METJA
Sequence: MINMKVAISMDVDKISNSFEDCKYFLIVRIDDNEVKSTKVIFNDESGKKSIVKENVNAIICKNISEENYKKFSKKIEIYHAEGDDVDKNISLFIEGELSKISNP
What are the official names of this protein?
Uncharacterized protein MJ0327.
Protein: LFTR_CAMJE
Sequence: MKSSNLYSKLLNAPKNAPVFLSQNLEADFIVKAYTFGLFPWTSKPVTWWCPDPRCILIPNQIHIQKNMKKFINLYQIKLDYDFLKLITLCRDTRSQSWIDDEFITTYYKLFTQGYAHSLELYENNELIGGIYGLILGKVFFGESMVSIKKNASKVAMIKLCDLLKPYDFIIDCQVYNQHLEFMGAHNISRKEFLNILKEKCNQESGFKNFKDLIT
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P5CR_STAHJ
Sequence: MKLVFYGAGNMAQAIFKGIINSKKLKSHDIYLTNKSNEEALKNFAEELGVEYSYDDEKLLQDADYVFLGSKPYDFEKVAQRIQPYINENNRFISIMAGLPINYIQEQLQVENPIARIMPNTNAQVGHSVTGISFSGNFGPKSKEEVNDLVNAFGSVIEVDEDHLHQVTAITGSGPAFLYHVFEQYVKAGTDLGLEKDQVEESIKNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLNALAQHDIEAIFKDCLNAAVHRSVELSKNEDN
What is the function of this protein?
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase, P5C reductase, P5CR, PCA reductase.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_MAGSA
Sequence: MSSAPTDAFFRTPLSERDPEVFAAITQELKRQQDQIELIASENIVSRAVLEAQGSVMTNKYAEGYPGKRYYGGCEFVDIAESLAISRACQIFGCSYANVQPSSGSQANQGVFMALLQPGDTIMGMSLAAGGHLTHGAAPNQSGKWFKAVQYGVRQQDSQIDFAEVEELARTHRPKLIIAGGSAYPRTIDFARFRKIADEVGAFFMVDMAHFAGLVAGGVYPNPLPHAHVVTTTTHKTLRGPRGGMILSNDADIGKKINSAIFPGIQGGPLMHVIAGKAVAFGEALKPEFKLYAKQVVDNARALADTLVRRGLDIVSGGTDSHLMLVDLRPKKLTGKAAEASLEHAGMTCNKNGIPFDPEKPTITSGVRLGTPAATTRGFGVEEFKKVGELIGDVLDGLAANPEDNSAAEARARAEVAELCRRFPIYQ
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PARP_IIV6
Sequence: MDNLKEEETNEINYIIDQLQKLNKKFKIYTVQRFKEEEPFNKYISESVSKKTRLLIHGTRCSSVIPILQTGLKIRPSTSVHFSGKVYGEGNYFSEHVQKSLNYTGWDNDQILLIYEVHVGNEYIYEGWYNGDRGIKLNYNELLQNGYNSTYVKAGNGLQNSEIISYNEDQSKIKYIIHITK
What are the official names of this protein?
Putative poly [ADP-ribose] polymerase-like 100L.
Protein: ALDH5_BACSU
Sequence: MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATADDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKAAFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLSMKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSFVEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAVFSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQTDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKFDSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGGEKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY
What is the function of this protein?
A benzaldehyde dehydrogenase able to act on substrates with 3- and 4-hydroxy and methoxy substitutions; converts vanillin (4-hydroxy-3-methoxybenzaldehyde) to vanillic acid in vitro (PubMed:26658822).  The physiological substrate is unknown (PubMed:26658822).
What are the official names of this protein?
Benzaldehyde dehydrogenase YfmT, Vanillin dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: ETT1_YARLI
Sequence: MAKRPLGLNKANKSKKKKLDSAEKAEKAVAKEISPENDESAEPAPALTLDADEEDDMGQLESLYKNWTSSERDSPRILHGVVHECDSLLQKAKGEGLPARFHEIYAASLLDLAEFADKKKPVKKKKVKSDDVAPETSDMFVDAALERVETGLEQYPEDAGLLFVKSRALKQDIDEKMSAVSKEERKETAKKMISQLNKILEVFKLAQKHASTVTPAQLDVVEELIELSGALESVVKQSDISETTLVACEKFYNEILASEKDENTVKKAHRGVGTCKMIVADSLLDLLDDDDEDNDDTVELAKKNLKAAIEHFQKSETDEDGEFMVTLAETMIQYGNLFETESDDQKKWYGEAVKRLRQAQRLGVGKYDEMILELEDD
What is the function of this protein?
Required for correct translation termination and probably involved in regulation of hypoxic gene expression.
What are the official names of this protein?
Enhancer of translation termination 1.
What is the protein family that this protein belongs to?
Belongs to the ETT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: JAL33_ARATH
Sequence: MAQKVEAGGGAGGASWDDGVHDGVRKVHVGQGQDGVSSINVVYAKDSQDVEGGEHGKKTLLGFETFEVDADDYIVAVQVTYDNVFGQDSDIITSITFNTFKGKTSPPYGLETQKKFVLKDKNGGKLVGFHGRAGEALYALGAYFATTTTPVTPAKKLSAIGGDEGTAWDDGAYDGVKKVYVGQGQDGISAVKFEYNKGAENIVGGEHGKPTLLGFEEFEIDYPSEYITAVEGTYDKIFGSDGLIITMLRFKTNKQTSAPFGLEAGTAFELKEEGHKIVGFHGKASELLHQFGVHVMPLTN
What is the function of this protein?
Sugar-binding protein showing significant affinity for (Glc alpha(1-4)Glc)(3) maltohexaose, (Glc alpha(1-6)Glc)(3) isomaltohexaose, Gal alpha(1-4)Gal beta(1-4)Glc, GalNAc alpha(1-3)(Fuc alpha(1-2)) and Gal beta(1-3)(Fuc alpha(1-4))GlcNAc beta(1-3)Gal beta(1-4)Glc.
What are the official names of this protein?
Jacalin-related lectin 33.
What is the protein family that this protein belongs to?
Belongs to the jacalin lectin family.
Protein: DSG2L_DANRE
Sequence: MGVASPLPNTYSAFFGDAAPPTVAAAVADRPLVSPCQSSASNGRRMAKICSISLLVVLSLSILNASASGEQQKKVRQKREWIIPPRKLRENVNYMYLDYIAKIRSDEETRTSIRYSLKGAGADQPPRDLFTVGSTDGKVKINGLLDREKTPVYYLQGVAKFLNGSNAEKDVDLRVVVLDENDCPPVFNLTIGAVSELSARDTLVMSITATDADEEGTLHTKIAYSIVEQSHAEMFYINRETGGIYVMHNTLDREKIDSYTLTVKGTDMNGAPGGNSGTGKVVINILDVNDNVPTLEKNIYECRVEENTRFVEVVRIQAIDADLIYTDNWLAVFTLVSGNEAGYFSITTDKKTNEGILMLNKELDYEELKEIRLQVSVSNKAHYHSSVVITGSKTYTIQVSVINQPEAPRFKPAVKVITISEESTTVILNKVITNYAAIDSDTMLIATNVRYAKGQDVDNWLIIDEKTADIRLNKIPDYESVFLKNYTYYAHILCITNETPAKTATGTIAIQVKDFNDHCPVLIHQSQKLCYEEHVVFVTAEDKDHFPNAHPFGFKVNTKHTKESWSVEHFNDTAAIFRSQETLWPGVYHLSVDVWDQQGKVCGAQLLRVEVCMCGAEKVCLPVTVVSRFGGSGVLLMLLGLLLLLLIPLLLLFCLCGAAGAAGDFKAIPFDAKEHLIAYNTEGQGEDKGMALLHMSKDENTRTNVGTVGGAQKQSDGKDGAVTAGGSHWSTFYHYDQFNNNAYHHHRDRTDGDFMYAQRKDEHSRFENYNAFDGLALSDAFLGNYYSQKSSHVAQKQALGDNLKVYEYEGQESRAGSFEDICSLMHEEEDLAFLDNLDMKFKTLAEICSGSTIQRESINVSSKKTESKDLSVQETSNILQSQEKKSSTILAGSVNQSSNMQQTSQEKKTSTIIAGSINQSSSLQHASTGVYLQEQVMLPNTTLLVQQPALYYAPAAPVYVVEPHPTVLVASGQVLGHQENQKRPKNAKHETHYQSLVYVEQQQPLRESQGSISGAVHMVNTEIMQSTEGHGVRREIRPARRVMMEEVREREVDSLHLRVPMSL
What is the function of this protein?
Component of intercellular desmosome junctions.  Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
What are the official names of this protein?
Desmoglein-2-like protein.
Protein: FMAF_ASPFU
Sequence: MLGRHECTISESVSALDPTAQEPEYTLVPSTSRDLVRDMTLNMEDAQAHLKEHGWVKIPAVLSKAEAEDALSRLWEAKAASEARGECTFQPILDPNPANVRVFYLPELDAYWRDMLVNPTALDLAKSLLGDQLLVSNFSANIARPGAESMALHSDQSIVLPAPWLDVWAVNVIWCLTRMTKENGATLYIPGSNKWTTWEDVPDNAPDLLVPFEADAGDIVVIDGRLWHTSGSNVTEDEDRAILFAYYSAPHMRPLTNWSAKLPKELQETLSPQLKELLALSHIGYVVKGDLTYMAQKYPSEKGTTAVSA
What is the function of this protein?
Dioxygenase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2) (PubMed:23488861, PubMed:24568283).  Within the pathway, the dioxygenase af480 acts as a 5-dehydro-6-demethoxyfumagillol dioxygenase that hydroylates 5-keto-demethoxyfumagillol at position C-6 (PubMed:24568283).  The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520.  The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps.  5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene.  The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin.  Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (PubMed:24568283) (Probable).
What are the official names of this protein?
Dioxygenase af480, 5-dehydro-6-demethoxyfumagillol dioxygenase, Fumagillin biosynthesis cluster C-6 hydroxylase, Fma-C6H.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: NRDR_ROSDO
Sequence: MRCPFCGNIDTQVKDSRPAEDHVSIRRRRFCPACGGRFTTYERVQLRDLVVIKSTGKREDFDRDKLERSIRISMQKRPIDPERIDQMISGIVRRLESMGETDIGSKQIGEIVMEALARIDTVAYVRFASVYKNFQAADDFDKFVSELRPDVPGDE
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: SYT_LISMO
Sequence: MKITFPDGAVKEFEPGVSTADIAASISPGLKKKALAGKLNGELLDLVTPIHEDGAIEIVTPDHEDALGILRHSTAHLMAQALKRLYPDVKFGVGPAIESGFYYDIDTEAVISDESLVEIEKEMQKIVRENVPIEREVVSREEAIKRFKAIGDQYKLELIEAIPEDETVTIYTQGEFFDLCRGVHVPSTGKIQVFKLLSVAGAYWRGDSNNKMLQRIYGTAFFDKNGLKEFIQMQKEAKERDHRKLGKELELFTNSIEVGQGLPLWLPKGATIRRVIERYIVDKEERLGYNHVYTPIMANVELYKTSGHWDHYHEDMFPTMKMDNEELVLRPMNCPHHMMIYKNDIHSYRELPIRIAELGMMHRYEMSGALSGLQRVRGMTLNDAHVFVRPDQIKDEFKRVVELILEVYKDFDITDYSFRLSYRDPKNTEKYFDDDAMWEKAQAMLKSAMDEMEMDYFEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGEDGEKHRPVVIHRGVVSTMERFVAYLIEEYKGAFPTWLAPVQMEIIPVNADAHLDYAKGVQDKLQRAGLRAEVDDRNEKLGYKIREAQTKKIPYALVLGDQEVEAGSVNVRRYGSKDSETMDLDAFIAQVVAEVSKY
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_OLEA2
Sequence: MTALTSAAIVGGGLAGCECARKLARAGIAVTLFEMKPHSFSPAHSSPELGELVCSNSLRSDEPEAGVGVLKQEMRALGSLVMEVAEATRVPAGKALAVDRGLFAASMTAAMEAEPGITLIRREITSLDDPALQGFDAVVIAAGPVASESLSRSLADAVGATHLYFYDAIAPIISADSVNMEKAFWGSRYRPEDTDYLNCPMNREEYFAFREALVEGEKAATKDFEKELHFEGCMPIEALAERGEMTLAFGPFKPVGLDDPRTGRRPFAVVQLRTENLNKTMFNLVGCQTKLKYGEQDRIFRMIPGLEDAEFVRYGSVHRNTYVNAPQVLNGDQSLKNRPDVFLAGQITGVEGYVESAANGMWLGMMLAARKHGENIPQPPVECALGALAAHLRTPVKKFQPSNINFGLTPELNQRARKKDRKALYAERARENFTQWYALLPASARS
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TF2LX_PAPHA
Sequence: MEAAADSPAETRSRVEKDSRRVEKDSRRPKKDSPAKTQSPAQDTSIMLRNNADTGKVLALPEHKKKRKGYLPAESVKILRRWMYKHRFRAYPSEAEKRMLSKKTNLSLSQISNWFINARRRILPDMLQRRGNDRIVGHKTGKDANATHLQSTDASVPAKSGPRGSDNVQSLPLRSSPKGQMSGEKIPEPGSAPSQKLTMIAQPKKKVKVSNITSSSSPEPVSTEEYADFSSFQLLVDAAVQRAAELELEKKQESNP
What is the function of this protein?
May have a transcription role in testis.
What are the official names of this protein?
Homeobox protein TGIF2LX, TGF-beta-induced transcription factor 2-like protein, TGFB-induced factor 2-like protein, X-linked, TGIF-like on the X.
What is the protein family that this protein belongs to?
Belongs to the TALE/TGIF homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SMD_ASPFN
Sequence: MQSISVLICVLLALSILNFTVASLTQRPIYAIAHRVLRNEAVTAALSHGANALEVDLTAWYFGWWADHDGKLFSAGSTARDLFKFIAQKQWTKDYNISFVWLDIKNPDFCRKGRPCSIEALRDLAREILEPAGIRVLYGFFETAESRGFKVIRDGLNSNEAVVLSGETSTILHLYNISGAGIPVKQMVMDFGDSWLRKGVDIYPELRYGSWKRDHGKLGKVFSWTSAQGDTEMVRYLLREAGIDGLIYGYQTDEYNDKSGPKSALKDIVDFVEAHSDTHRMATEDDAPW
What is the function of this protein?
Catalyzes the hydrolysis of sphingomyelin.  Sphingomyelinases D are produced by some spider in their venoms, but also by arthropods such as ticks, or pathogenic bacteria and fungi.  They might play a role in pathogenicity through different mechanisms, such as membrane destabilization and host cell penetration, but also pulmonary inflammation and cutaneous lesions.
What are the official names of this protein?
Sphingomyelinase D, SMase D.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelinase D/phospholipase D family.
What are the subcellular locations of this protein?
Secreted.
Protein: STAC3_MOUSE
Sequence: MTEKEVVESPQPPFPGETPQSGLQRLKQLFKKGSPETAEMEPPPEPQANGEAVGAGGGPIYYIYEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFRRAYSSPLYSDQQYAVSAANRNDPVFETLRVGVIMANKERKKGQADKKNPLAAMMEEEPESARPEEGKSQDGNNAEKDKKAEKKTPDDKNKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI
What is the function of this protein?
Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization (PubMed:23818578, PubMed:27621462, PubMed:29467163).  Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction (PubMed:23818578).  Probably functions via its effects on muscle calcium channels.  Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane (PubMed:27621462).  Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (PubMed:25548159, PubMed:27621462, PubMed:29467163).  Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593).
What are the official names of this protein?
SH3 and cysteine-rich domain-containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane, sarcolemma, T-tubule. Note=Co-localizes with CACNA1S and CACNA1C on T-tubules.
Protein: ISDB_STAAT
Sequence: MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPATPSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTTPTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLPRKRKN
What is the function of this protein?
Cell wall-anchored surface receptor that extracts heme from oxidized metHb to enable growth on hemoglobin as a sole iron source.  Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays it to the membrane transporter/IsdEF for internalization.  Promotes also resistance to hydrogen peroxide and killing by neutrophils.
What are the official names of this protein?
Iron-regulated surface determinant protein B, Fur-regulated protein B, Staphylococcal iron-regulated protein H, Staphylococcus aureus surface protein J.
What is the protein family that this protein belongs to?
Belongs to the IsdB family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A.
Protein: YM084_YEAS7
Sequence: MCGIFGYCNFLIEKTRGEIIDTLIEGLQALEYKEYDSSGISIQGDELKSLNIYKQTGKISSLKEEIDLYNLNKNLPFISHCGIAHTRRATHGGLRRANCHPHNSDPSNEFVVVHNGVITNFANLKALLVAKGYVFKSDTDTECIPKLYKHIYDTSIELGYNLDFHVLTNLVLKELEGSYGLLCTSSHFPDEVVAARKGSPLVIGVKGKTDMDVNFVEVEYLDQEEDYLKLNTQTKSSGNVLAAAPVKYNTCLRKSPPLRSQYLRNSTTSTFNHGSSTETPAENGLPRPMEFYLSSDCASLARYVSKVVYLEDNDIAHIYDGELHIHCSKIGSEDFSFRTELSKIKKGPYDNFMQKEIYEQCETTKNVMRGRVDAFTNRVVLGGLENWLTELRRAKRIIMIASKASFHSCLAARPIFEELMEVPVNVELALDFVDRNCCIFRNDVCIFVSRSGETTDTINALNYCIKKEAVTIGVVNCSGSSISRFTHCGVHTNTGPEKGIATTKSYTSQYIALVMIALWMSEDLVSKIERRKEIIQALTIVPSQIKEVLELEPLIIELCDKKLKQHDTFLLLGRGYQFASALEGASKMKEISYVHSESILTNELGHRVLAVASDNPPIIAFATKDAFSPKIASCIDQIIERKGNPIIICNKGHKIWEQDKQKGNVVTLEVPQTVDCLQGILNVIPLQLISYWLAIKKDIGVDLPRDSAMSAPDI
What is the function of this protein?
Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).
What are the official names of this protein?
Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing], GFAT, D-fructose-6-phosphate amidotransferase, Hexosephosphate aminotransferase.
Protein: RHOH_HUMAN
Sequence: MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQREMGPHRASCVNAMEGKKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRRLFSINECKIF
What is the function of this protein?
Negative regulator of hematopoietic progenitor cell proliferation, survival and migration.  Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70.  Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways.  Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling.  Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection.  Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction.  Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity).  Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.  Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF.  Inhibits activities of RAC1, RHOA and CDC42.  Negatively regulates leukotriene production in neutrophils.
What are the official names of this protein?
Rho-related GTP-binding protein RhoH, GTP-binding protein TTF, Translocation three four protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Colocalizes together with ZAP70 in the immunological synapse.
Protein: METE_ALCBS
Sequence: MTTLHNLGFPRIGARRELKQAQEAYWAGDLQQSELEHVGKSLRERHWALQADAGVDLMPVGDFAWYDHILEFSSLLGVVPSRFEQDANAPVNLDTLFRMARGRAPTGTPAAACEMTKWFDTNYHYLVPELAADQTFRIARESLFEQVEEAKAQGHNPKPVIPGPLTYLYLSKGDRFEGAEDSAKLALLDNLIPVYREILQRFANQGVQWVQIDEPILVLDLPDSWQRAYLRVYDQLASASQTKLLLATYFGGLGNNLFTALELPVHGLHLDRVRGNDDLGQVIPRLGDKVLSLGVINGRNIWRTDLDAALDNITALHNELGDRLWLAPSCSLLHCPVDLEQEDTLDNELKSWLSFAKQKLEELALLGGALRGNSNVNSGLQTQRAALQARGLSSRIHNPAVAQRLADASQLSRDRVSPFAERIAQQQHALQLPAFPTTTIGSFPQTREIRTARRDWKAGKLNDAQYQQQMQEEIARCIRYQEEVELDVLVHGEAERNDMVEYFGELLDGFAFTRFGWVQSYGSRCVKPPIIFGDVQRPQAMTVEWARYAQSLTHKPVKGMLTGPVTILQWSFVRDDQPRADTCRQIALALRDEVQDLEKAGIKVIQIDEPALREGLPLRQEEWTQYLDWAVDCFRLATVSVDDDTQIHTHMCYSEFNDIIEAIAALDADVITIETSRSNMELLDAFRDFHYPNDIGPGVYDIHSPNEPDVAWMVQLMEKAAERLPKERLWVNPDCGLKTRKWDETRAALANMVNAAKQLRQAS
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: TRMFO_GLOVI
Sequence: MIEPVRVIGGGIAGAEAAWQCARAGVPVVLSEMRPVRPSPAHHTDHLGELVCSNSFGAMATDRAPGLLKEELRRLGSLVIAVADAHAVPAGGALAVDRAVYTRELTERVANHPLIELRREEVTEIPAAGLVVFATGPLTSEPLAHGLQALTGLGYLSFFDAASPIVAGESLDTEKVFLASRYDRGEAAYYNCPMSEPEYRAFWEALASAEQAELKEFEHEERKFFEACLPVEELARRGYETLRYGPLKPVGLTDPRTGRWPFACVQLRQEDRAGRLWNLVGFQTNLKWGEQKRVFQMIPGLEQAEFVRLGVMHRNTFLCSPHLLAPTLQFHAHPRLLACGQLTGTEGYTAAVAGGWLAGTNAARLAQSRDPLVLPVETMAGALVDYVSHGDPKTFQPMPPNFALLPEITPRIRHKQQRYWAYRDRALAAIDTFGRTHGLGAAPALARAN
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.