PharMolix/UniProtQA huggingface dataset:
Protein: CFI_EUSER
Sequence: MAPPVSVSEVQVESYLFPPTITPPASTKSFLLGGAGVRGLEIGGNFVKFTAIGIYLDETAIPWLAGKWKGKTAEELADSVDFFADIITGPFEKFTQVTLILPLTGQQYSGKVSENCTAQWKAAGVYTPADGKAIEKFLQVFEPQSFSPGDSILFMHSPESLTISFGKAGDIPETSNAVIENKKLSEAVIESVIGEKGVSPAAKKSLATRIAHVLNHF
What is the function of this protein?
Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones.  Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin (By similarity).
What are the official names of this protein?
Chalcone--flavanone isomerase, Chalcone isomerase.
What is the protein family that this protein belongs to?
Belongs to the chalcone isomerase family.
Protein: TRMD_GEOSL
Sequence: MKFDILTLFPAMFDGPLTESIIRRAVERGFVDISLHNIRDYATDRHRVVDDAPYGGGDGMVMKVEPLAACIEAVKAERPAARVILTTPRGRRFDHDAARELAGYEELIIVCGRYEGIDERVRDLFVDDEFSIGDFVLTGGELAAMVMIDAVIRFIPGVLGSPGSAEYDSFADGLLEYPQYTRPVEFRGVQVPGVLLSGNHAEISRWRRQKALELTRRVRPDLLHKAELSSSDRDCLAMLEREGEP
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMM_SALPB
Sequence: MNKVVLLCRPGFEKECAAEITDKAGKREIFGFARVKENAGYVIYECYQPEDGEKLISELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELMKFCRKFTVPLRAALRDAGVLTNYETPKRPVVHVFFIAPGCCYTGYSFAHNNSPFYMGIPRLKFPSDAPSRSTLKLEEALHVFIPEDEWDERLANGMYAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFRYRPNRNNISWMVCDMVEKPAKVTALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYLQAQLDEHGVNAQIQARQLYHDREEVTVHVRRLWAAVGGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH4_BURMS
Sequence: MNLMNPEFAMPDVQSTVDTRQMPIQRVGVRAVRHPLTVRTAEGETQATVGTWNLDVHLPADQKGTHMSRFVALLEERGGPLTADAFRTMLATMLEKLEARAGRIEVSFPYFVNKTAPVSGVRSLLDYEVTLTGDVRDGLTRVFAKVLVPVTSLCPCSKKISQYGAHNQRSHVTIDAELAADVPVEDLIRIAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDVARRLDADERIVAYVLEAENFESIHNHSAYALIERDKRRGA
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RL4_SALPA
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: HECW1_CAEEL
Sequence: MGDEFPFHHLGYVCLNEIYKHLTLKEIFQLSFSSNQIKRSLGIASIPVKSIFVNFDSQYPKIKLIGESSQLEWVFGIPDGLEYTDVGVYKIGHFKFQCKTSGTAFYTEHYDLENAMLVVIRYMISIFKCSNSIITYLSIDLGVIEDSRAICENFVAFKKVERLSIFQTNYGVERNTLNFAQSFDWICDNLEIKNIHIGADVLEPKMVQKTNGEFDIKLCARRFEQVLTMDHIYLQHADWITSEDLLNLDVQTAMLIENNLTEQDLNAFIKQWLRSDSDKLWWLEVKGKMMFNREEVLKDLDVQDDAYRSLNTRWYVARRSRANPSGNGCARKKMGSLRPKLTELWPFKVYIIFGSILIVFGPAALNRMITLRRMDVETDRPSGSETGIFVSKSAVYPFGNKNEVVKVWWNIDKPENCLDWIGLFDNNDSSFYLDQKSLRQHISPVVFTLTSKNLLNASEVYFGLIDGMTGRLLAKSENVEICKSASLVVHEVKKPENINVYLNTNHGRIEIPKKRSFSRKNGSFRSSFEFDFDVEDLHISLVENSEKLNFDHFIASNQLQNNYIQSKSFSHSHVVEIVFSIEPKTSKKSAPDIMEIASSSQTPPESHWKTYLDAKKRKFYVNHVTKETRWTKPDTLNNNHIEPETPVHKRLSDRSASPRNSFITPRRTITVRSAGCPKSDLIQFFQRDEFKTALYENQDAMQIYNECSVVRHAIHRIQKDLDPPSKFENQPLFVRFVNLFADITQPLPSGWECITMNNRTVFLNHANKETSFYDPRIRRFETKTSRRGRSVPSRSSTAHKGKIDHALISKCEDLRKIAQDNFPQIAERISKKLMLIERFGGLAVASLANDLDITLALSMLDSNTEKLAGEGDNIKMFYEDMKKEKLGKGPSRLCWKVSRDRLLDDAFRIILNVDPFVLKKSRLHIRFEGELALDYGGLSREFFILLSRELFHPKNGYFEYEGNDYHLQLRPRGCETEKEKKWLILCGRVLALAVIHRCYIDVFFTNVFYKSLQKRPVTLMDFKESDAEFYKSMNWLLENDVVDLEMSFVYSSMVNGKLAEQELVPGGESQMVTEANKAEFIDLMCQKKAIRGVEKPLEILLTSFNQILNDNLLNSLESSDLKRILSGSLELDLNDWRTNTIYKGGYSDCHIVVEWFWEVIETMTNQERFDLLLFVTGSSSVPFEGFSALRGNEEISKFCIEKWGDATSFPRAHTCFNRLQLPSYNTKQQLKSKLQQAIVNGMSYSIE
What is the function of this protein?
E3 ubiquitin-protein ligase (By similarity).  Functions in the OLL neurons in the anterior ganglion to inhibit avoidance to microbial pathogens such as P. aeruginosa although worms do display avoidance behavior, vacating a P. aeruginosa lawn within 24 hours (PubMed:22089131).  Likely to act by inhibiting the neuropeptide receptor npr-1 (PubMed:22089131).
What are the official names of this protein?
E3 ubiquitin-protein ligase hecw-1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCD1_ARCFU
Sequence: MMDVAILVDENTRVIVQGITGFQGSFQAKRMLDYGTKVVGGVTPGKGGSEVHGIPVYNTVEEAVAETNADTSIIYVPARFATDAIFEAFDAGLRLVVCVTEGIPLYDEMLIHRKLREVKSMLLGPNCPGVISPGRSKVGLLPDRSFTQGNLGVVSRSGTLTYQICENLTKAGIGQSTVVGIGGDPMPGLTFVDVLKMFEEDEETKAVLLVGEIGGTAEEKAAEFIKQMSKPVVAFIAGRTAPPGKRMGHAGAIIEGSTGTAEAKMAALRDAGARVAETLLDVVKEVRRVLE
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit alpha 1, Succinyl-CoA synthetase subunit alpha 1, SCS-alpha 1.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase alpha subunit family.
Protein: RISB_HELPS
Sequence: MQIIEGKLHLQGNEKVAILTSRFNHIITDRLQEGAIDCFKRHGGDENLLDIVLVPGAYELPFILERLLGSEKYDGVCVLGAIIRGGTPHFDYVSAEATKGIANAMLKYSMPVSFGVLTTDNVEQAIERAGSKAGNKGFEAMSTLIELLSLCQTLKG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RL6_HAEI8
Sequence: MSRVAKAPVNIPAGVEVKLDGQLLTVKGKNGELSRKIHESVEVKQDNGQFTFTPREGFVEANAQSGTARALVNAMVIGVTEGFTKKLVLVGVGYRAQLKGNAIALSLGYSHPVEHTLPVGITAECPSQTEIVLKGADKQLIGQVAADIRAYRRPEPYKGKGVRYADEVVRIKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: TRPC_SACS2
Sequence: MPRYLKGWLKDVVQLSLRRPSFRASRQRPIISLNERILEFNKRNITAIIAEYKRKSPSGLDVERDPIEYSKFMERYAVGLSILTEEKYFNGSYETLRKIASSVSIPILMKDFIVKESQIDDAYNLGADTVLLIVKILTERELESLLEYARSYGMEPLIEINDENDLDIALRIGARFIGINSRDLETLEINKENQRKLISMIPSNVVKVAESGISERNEIEELRKLGVNAFLIGSSLMRNPEKIKEFIL
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: TRHO_XANC8
Sequence: MITNTAAYQFAPIHDPQQLADSVLERAQQRALKGSVLVAEEGINLFLAGDAEQIASFYAWLHADARFAQMRVKYSHSAEQPFARLKVKVKPEIISFRRDDASPLQGRAPSVAPAVLRKWMQQGHDDHGRPLVLLDTRNAQEVAYGTFQGALTLPIDKFTELPEALQPHRAALADATVVSFCTGGIRCEKAALWMHAEGMDNVLQLEGGILGYFEDVGGEGYDGRCFVFDERVALDAELRPLVDGAACADAGKI
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: JMJ24_ARATH
Sequence: MQVNFDETCDSVIRMNANEQTRSANGIGNGNGESIPGIPDDLRCKRSDGKQWRCTAMSMADKTVCEKHYIQAKKRAANSAFRANQKKAKRRSSLGETDTYSEGKMDDFELPVTSIDHYNNGLASASKSNGRLEKRHNKSLMRYSPETPMMRSFSPRVAVDLNDDLGRDVVMFEEGYRSYRTPPSVAVMDPTRNRSHQSTSPMEYSAASTDVSAESLGEICHQCQRKDRERIISCLKCNQRAFCHNCLSARYSEISLEEVEKVCPACRGLCDCKSCLRSDNTIKVRIREIPVLDKLQYLYRLLSAVLPVIKQIHLEQCMEVELEKRLREVEIDLVRARLKADEQMCCNVCRIPVVDYYRHCPNCSYDLCLRCCQDLREESSVTISGTNQNVQDRKGAPKLKLNFSYKFPEWEANGDGSIPCPPKEYGGCGSHSLNLARIFKMNWVAKLVKNAEEIVSGCKLSDLLNPDMCDSRFCKFAEREESGDNYVYSPSLETIKTDGVAKFEQQWAEGRLVTVKMVLDDSSCSRWDPETIWRDIDELSDEKLREHDPFLKAINCLDGLEVDVRLGEFTRAYKDGKNQETGLPLLWKLKDWPSPSASEEFIFYQRPEFIRSFPFLEYIHPRLGLLNVAAKLPHYSLQNDSGPKIYVSCGTYQEISAGDSLTGIHYNMRDMVYLLVHTSEETTFERVRKTKPVPEEPDQKMSENESLLSPEQKLRDGELHDLSLGEASMEKNEPELALTVNPENLTENGDNMESSCTSSCAGGAQWDVFRRQDVPKLSGYLQRTFQKPDNIQTDFVSRPLYEGLFLNEHHKRQLRDEFGVEPWTFEQHRGEAIFIPAGCPFQITNLQSNIQVALDFLCPESVGESARLAEEIRCLPNDHEAKLQILEIGKISLYAASSAIKEVQKLVLDPKFGAELGFEDSNLTKAVSHNLDEATKRPQQNSCT
What is the function of this protein?
Binds histone H3 but seems to have lost demethylase activity probably due to its inability to bind iron Fe(2+) (PubMed:26979329).  Possesses E3 ubiquitin ligase activity and targets directly CMT3 for proteasomal degradation to initiate destabilization of the heterochromatic state (e. g.  CHG cytosine methylation and H3K9me2) of endogenous silenced loci (PubMed:26798133, PubMed:26979329).  Required for the removal of repressive H3K9me2 histone marks to facilitate the transcription of AtSN1, AtMu1c, solo LTR and SDC, thus counteracting their transcriptional silencing (PubMed:26119694, PubMed:26979329).  Mainly required to promote the basal level transcription of silenced loci such as TE and repeats targeted by RNA-dependent DNA methylation (RdDM) for silencing, a specialized branch of the RNA interference (RNAi) pathway (PubMed:26119694, PubMed:28400174, PubMed:26979329).  Cooperates also with RNAi pathways for gene silencing both by contributing to the production of 24-nt siRNA to initiate RdDM and by recruiting RDR2 to enable local transcripts to make dsRNA (PubMed:26119694, PubMed:28400174).  Antagonizes histone H3K9 demethylase IBM1/JMJ25 function (PubMed:28400174).
What are the official names of this protein?
E3 ubiquitin-protein ligase JMJ24, Inactive histone demethylase JMJ24, Jumonji domain-containing protein 24, AtJMJ24, Protein JUMONJI 24.
What is the protein family that this protein belongs to?
Belongs to the JARID1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OBG_CLOAB
Sequence: MFVDKARIFVKSGDGGDGAVSFRREKYIPLGGPDGGDGGEGGDVILVVDPNMTTLLDFKYKRKYVSERGQNGQGAKCYGRDGKDLYIKVPMGTIIRDVETDKIMADLAHKDDKFVIVKGGRGGKGNVKFCTPTRQAPNFAQPGMPGEERWISLELKLLADVGLIGFPNVGKSTLLSVASKARPKIANYHFTTITPNLGVVDVSGISSFVMADIPGIIEGASEGVGLGFEFLRHIERTRLLVHVVDISGSEGRDPLEDFLKINEELKKYNIKLWDRPQIVAANKADMVYDDDQFNKFREELNKLGYKNVFKISAATRMGVEDLLKECARVLSTIPVTDMEIPEEERFVPEDKHFTYTIRKEGDTYIVEGTFVDRLLASVNVNEPDSFRYFHKVLRNKGVMAELEEMGIKDGDMVRLNDFEFEFLK
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOLE_KLEP3
Sequence: MNKDNVKLAIAPIGWTNDDMPELGSENTFQQIVSEMALAGFTGSEVGSKYPRDPAVLKPMLDIRGIQICNAWFSTFFANGQREKTIDEFVNHMNFLHAMGANVIGCSEQSGSIQGLDKPILGDAKPCFSEEEWQRVAEGYNTLGRLAAEKGMQVCLHHHMGTGIQTTAEIDKFMSLVDERVFLLFDTGHAWYSEGGEAPMLAILKKYLPRINHVHLKDVRPPVIDQVRRDGLSFLDGVKKGTFTVPGDGVIDFRPVFKLLDDFGYKGWMVVEAEQDPALANPFEYAVKARKYIRETAGI
What is the function of this protein?
Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).
What are the official names of this protein?
Inosose dehydratase, 2-keto-myo-inositol dehydratase, 2KMI dehydratase.
What is the protein family that this protein belongs to?
Belongs to the IolE/MocC family.
Protein: RAMB_MYCTU
Sequence: MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDRDLDIAIDPHEVAEMVSAHPGLACAVVNLHRRYRITTAQLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHALDTAAEDLTAQMRMHHGDLARELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAELAYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVRVDRAGNMSKRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVARTVELRAARYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIGAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL
What is the function of this protein?
Involved in the control of the glyoxylate cycle.  RamB negatively controls the expression of icl expression during growth on acetate as the sole carbon source.  Does not regulate the expression of other genes involved in acetate metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator RamB, icl1 and ramB operon repressor protein.
What is the protein family that this protein belongs to?
Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.
Protein: GPI18_ASHGO
Sequence: MECFKRLTTVFFTVKLVQYLLVYFAPGQFDTSTPLFLEKYQPLQPEKWYHKLLSWDSVYFVKNGLQAVTHTNAYGYVSLPEYEHEWMFSPFVWSQTLKTAGGATLRNWAAPIDTLLVRATLLNLVLHYVSVWLLYALTLRTFPKNRELAYKTSLLFILSSAAGFLLAPYSEPLSFAFSFLGMLLRMLAVEHNVYGGITLAWYNWLPYTLSGICFSVAAANRPNCVLLGVYYIYDVLKLVRQRNWVRAVLFPCIAGSMMLGIFAYMHYYLPSVVFCPERESWCKHSLPWIHIPYKSFYSFVQGYYWRNGFLNYWTWNNVPNFLFALPNLVILWYSTVYFSYQYPLESIRPLVYITRALLLIITFFAHVQIINRISSFIPLHLWYLSDRMIKTTGEAKGDDRLVYLYVNWLILWIPLQTVLFACFLPPA
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 2, GPI mannosyltransferase II, GPI-MT-II, Glycosylphosphatidylinositol-anchor biosynthesis protein 18.
What is the protein family that this protein belongs to?
Belongs to the PIGV family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YOJA_BACSU
Sequence: MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDINKIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVVVASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAPTAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRKEFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISLLLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADFFRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAGSVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM
What are the official names of this protein?
Uncharacterized permease YojA.
What is the protein family that this protein belongs to?
Belongs to the GntP permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: C2TA_HUMAN
Sequence: MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEEEIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFKHIGPDEVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKPAEPPTVVTGSLLVRPVSDCSTLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSMPEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAELAKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR
What is the function of this protein?
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter.  No DNA binding of in vitro translated CIITA was detected.  May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both.  Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.  Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes.  Activates CD74 transcription (PubMed:32855215).  Exhibits intrinsic GTP-stimulated acetyltransferase activity.  Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).  Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2.  Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215).
What are the official names of this protein?
MHC class II transactivator, CIITA.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Note=Recruited to PML body by PML.
Protein: Y3247_YERPY
Sequence: MPSFDIVSEIDMQEVRNAVENATRDLANRWDFRNVPASFELNEKNESIKVVSESDFQVEQLLDILRAQLSKRGIEGAALEIPEEMARSGKTYSVDAKLKQGIESVQAKKLVKLIKDSKLKVQAQIQGEQVRVTGKARDDLQAVMALVRAADLGQPFQFNNFRD
What are the official names of this protein?
UPF0234 protein YPK_3247.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: AROB_GEOTN
Sequence: MMERTIETATKQYPLLLGDGAARALPRLLRSLACPPGTKLFIITDDAVAPLYLDEVRAMLAAAEYDVYAYIIPSGEAAKSFDNYYACQTAALQCSLDRRSVIIALGGGVVGDLAGFVAATYMRGIRYIQMPTTLLAHDSAVGGKVAINHPLGKNMIGAFHQPEAVVYDTTFLRTLPERELRSGFAEVIKHALIRDRRFYEWLRAEVKTLADLRGEALTYCIEKGIDIKASIVREDEKETSVRAHLNFGHTLGHALESELGYGTLTHGEAVAIGMLFAVFVSERLYGHSFAEHRFAEWFARYGFPVSLPTTVEADRLLEKMKGDKKAYAGTVRMVLLREIGDVEVVELEDDKLLAWLDEFAKQGGGR
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_AGRFC
Sequence: MDRIRITGGNKLNGVIPISGAKNAALPLMIASLLTSDTLTLENVPHLADVEQLIRILGNHGVDISVNGRRESQGEAYSRTVHFTCRTIVDTTAPYELVSKMRASFWVIGPLLAREGRARVSLPGGCAIGTRPVDLFIEGLQALGATMEIDGGYINASAPKGGLIGAVYTFPKVSVGATHVMLMAASLARGTTVIHNAAREPEVVDLAHCLIAMGAKIEGAGTSTITIEGVTSLSGARHRVLPDRIETGTYAMAVAMAGGDVVLEGTRASLLDNALDTLRLAGVTISDTDTGLRVVRNGNGIQPVDIVTEPFPGFPTDLQAQFMALMTRSQGVSHITETIFENRFMHVQELARLGAKISLSGQMARIEGVTRLKGAPVMATDLRASVSLVIAGLVAEGETMVSRVYHLDRGFERLEEKLTRCGALVERVSD
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_PSEMY
Sequence: MSLSRIMVTAVRNLHPVTLSPSPRINILHGANGSGKTSVLEAIHLLGLARSFRSTRLQPVIHYEQPACTVFGQVQLAEGGSSNLGISRDRQGELQIRIDGQNARSAAQLADLLPLQLINPDSFRLLEGAPKIRRQFLDWGVFHVEHRFLGAWQRLQKALRQRNSWLRHGTLDGASQAAWDRELCSASQEIDTYRRAYIQALKPVFERTLAELLQLEGLTLSYYRGWDKDRELSEVLASSLLRDQQLGHTQAGPQRADLRLRLAGHNAAEILSRGQQKLVVCALRIAQGHLVNEAKRGQCIYLVDDLPSELDEQHRQALCRLLEDLHCQVFITCVDHELLREGWHTDTPVAMFHVEHGRITQTQDHRE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPC2_YEAST
Sequence: MTHSLKALFALLFLYTAAVNAGVIGIFNALPPPNTKPINGESPLYQCDILDKQLVEIKEVNLDPNPPVRGENLTISANGEVFETIEEGAYIDVEVRLGYIRLLSQTFDLCETLEDNDIEGLSCPIEPGEYNIKKIVEIPGEVPPGKYVVVARAYTEKDDLITCLTGEVIFPPR
What is the function of this protein?
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
What are the official names of this protein?
Phosphatidylglycerol/phosphatidylinositol transfer protein, PG/PI-TP, NPC2 homolog.
What is the protein family that this protein belongs to?
Belongs to the NPC2 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: CCND1_HUMAN
Sequence: MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
What is the function of this protein?
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162, PubMed:33854235).  Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162).  Hypophosphorylates RB1 in early G(1) phase (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162).  Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1833066, PubMed:1827756, PubMed:8302605, PubMed:19412162).  Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418).  Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657).  Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529).
What are the official names of this protein?
G1/S-specific cyclin-D1, B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, PRAD1 oncogene.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin D subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.