PharMolix/UniProtQA huggingface dataset:
Protein: SYH_YERP3
Sequence: MAKNIQAIRGMNDYLPADTAIWQRIESILKQVLSGYGYSEIRMPIVEQTPLFKRAIGEVTDVVEKEMYTFDDRNGESLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRYERPQKGRYRQFHQLGAEVFGLPGPDIDAELILLTARWWRALGIFEHVKLELNSIGSLAARADYREALVAFLEQHVEVLDEDCKRRMYSNPLRVLDSKNPDVQQLLDDAPKLSDYLDEESKQHFAGLCELLDKASIPYTVNERLVRGLDYYNRTVFEWVTHSLGAQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNADFQVPATVDAYVISSGEGSQSAAMLLAESLRDALPTLKIMTNYGGGNVKKQFTRADKCGARVALMLGESEVAAQQVVVKDLRNGEQETLAQADVAARLALMLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_THET8
Sequence: MDAVKKAILGEVLEEEEAYEVMRALMAGEVSPVRAAGLLVALSLRGERPHEIAAMARAMREAARPLRVHRRPLLDIVGTGGDGKGLMNLSTLAALVAAAGGVAVAKHGNRAASSRAGSADLLEALGVDLEAPPERVGEAIEELGFGFLFARVFHPAMRHVAPVRAELGVRTVFNLLGPLTNPAGADAYVLGVFSPEWLAPMAEALERLGARGLVVHGEGADELVLGENRVVEVGKGAYALTPEEVGLKRAPLEALKGGGPEENAALARRLLKGEEKGPLADAVALAAGAGFYAAGKTPSLKEGVALAREVLASGEAYLLLERYVAFLRA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: GT253_BOVIN
Sequence: MRAAPAAPLLQLLLLLGPRPEAAGVAEPPLPTVVLAILARNAEHSLPHYLGALERLDYPRARLALWCATDHNVDNTTAMLREWLAAVGDNYAAVVWRPEGEPRSYPDEEGPKHWTKERHQFLMELKQEALTFARDWGADYILFADTDNILTNNQTLRLLIEPGLPVVAPMLDSQTYYSNFWCGITPQGYYRRTADYFPTKNRQRRGCFRVPMVHSTFLVSLRAEGTGQLAFYPPHPNYTWPFDDIIVFAYACQAAGVAVHVCNEQRYGYLNVPVKSHQGLEDERVNFIHLILEALVDGPPMWASAHVSRPPKRPSKMGFDEVFVISLARRPDRRERMLTSLWEMEISGRVVDAVDGRMLNSSVMRTLGVDLLPGYQDPYSGRTLTKGEVGCFLSHYSIWEEVVTRGLAQVVVFEDDVRFESNFKGRLEQLMEEVEAEKLPWDLIYLGRKQVNPEEEAVVEGLPHLVAAGYSYWTLAYVLSLAGARKLLASQPLRRMLPVDEFLPIMFDQHPNEQYKAHFWPRDLQAFSARPLLAAPTHYAGDSEWLSDTETSSPWDDDSGRLISWTGSYKTLRGPRLDLAGGSGHSLRPHPRDEL
What is the function of this protein?
Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier.  Does not express any beta-galactosyltransferase activity in vitro.
What are the official names of this protein?
Probable inactive glycosyltransferase 25 family member 3, Cerebral endothelial cell adhesion molecule.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 25 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: T1M_BACTN
Sequence: MATNSSTEQSLTKKVWNLATTLAGQGIGFTDYITQLTYLLFLKMDAENVEMFGEESAIPTGYQWADLIAFDGLDLVKQYEETLKLLSELDNLIGTIYTKAQNKIDKPVYLKKVITMIDEEQWLIMDGDVKGAIYESILEKNGQDKKSGAGQYFTPRPLIQAMVDCINPQMGETVCDPACGTGGFLLTAYDYMKGQSASKEKRDFLRDKALHGVDNTPLVVTLASMNLYLHGIGTDRSPIVCEDSLEKEPSTLVDVILANPPFGTRPAGSVDINRPDFYVETKNNQLNFLQHMMLMLKTGGRAAVVLPDNVLFEAGAGETIRKRLLQDFNLHTILRLPTGIFYAQGVKANVLFFSKGQPTKEIWFYDYRTDIKHTLATNKLERHHLDDFVSCYNNRVEIYDAENNPQGRWRKYPVDEIIARDKTSLDITWIKPGGEVDDRSLAELMADIKDKSQTISRAVTELEKLLANIEEN
What is the function of this protein?
The subtype gamma methyltransferase (M) subunit of a type I restriction enzyme.  The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues of an undetermined sequence.  In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site.  Whether the DNA is cut or modified depends on the methylation state of the target sequence.  When the target site is unmodified, the DNA is cut.  When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated.  After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.
What are the official names of this protein?
Type I restriction enzyme BthVORF4518P methylase subunit, M protein, Type I methyltransferase M.BthVORF4518P, M.BthVORF4518P.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: RL18_THENN
Sequence: MIKKESRNERRIRRHRRVRKKVFGTPERPRLCVFRSNKHIYAQIIDDTIGHTLVSASTLDPELREKLQKTWNIEAAKEVGLLIGKRAIEKGIKKVVFDRGGYKYHGRVKALADGAREAGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: POLG_ASGVP
Sequence: MAFTYRNPLEIAINKLPSKQSDQLLSLTTDEIEKTLEVTNRFFSFSITPEDQELLTKHGLTLAPIGFKSHSHPISKMIENHLLYICVPSLLSSFKSVAFFSLRENKVDSFLKMHSVFSHGKIKSLGMYNAIIDGKDKYRYGDVEFSSFRDRVIGLRDQCLTRNKFPKVLFLHDELHFLSPFDMAFLFETIPEIDRVVATTVFPIELLFGDKVSKEPRVYTYKVHGSSFSFYPDGVASECYEQNLANSKWPFTCSGIQWANRKIRVTKLQSLFAHHVFSFDRGRACNEFNHFDKPSCLLAEEMRLLTKRFDKAVINRSTVSSLSTYMACLKTANAASAVAKLRQLEKRDLYPDELNFVYSFGEHFKNFGMRDDFDVSVLQWVKDKFCQVMPHFIAASFFEPTEFHLNMRKLLNDLATKGIEVPLSVIILDKVNFIETRFHARMFDIAQAIGVNLDLLGKRFDYEAESEEYFSENGYIFMPSKSNPERNWILNSGSLKIDYSRLVRARRFRLRRDFLDPISKGKSPRKQLFLESTGNIKSNPNAEKNSESGEIKIEGSAENDQPHEVSHTSMETEDGQGFEGSIPVDLINCFEPEEIKLPKRRRKNDCVFKAISAHLGIDSQDLLNFLVNEDISDELLDCIEEDKGLSHEMIEEVLITKGLSMVYTSDFKEMAVLNRKYGVNGKMYCTIKGNHCELSSKECFIRLLKEGGEAQMSNENLNADSLFDLGRFVHNRDRAVKLAKSMARGTTGLLNEFDLEFCKNMVTLSELFPENFSSVVGLRLGFAGSGKTHKVLQWINYTPSVKRMFISPRRMLADEVEPQLKGTACQVHTWETALKKIDGTFMEVFVDEIGLYPPGYLTLLQMCAFRKIVKGQSENFLKGKLLELSKTCLNIRCFGDPLQLRYYSAEDTNLLDKTHDIDLMIKTIKHKYLFQGYRFGQWFQELVNMPTRVDESKFSRKFFADISSVKTEDYGLILVAKREDKGVFAGRVPVATVSESQGMTISKRVLICLDQNLFAGGANAAIVAITRSKVGFDFILKGNSLKEVQRMAQKTIWQFIIEGKSIPMERIVNMNPGASFYESPLDVGNSSIQDKASNDLFIMPFINLAEEEVDPEEVVGDVIQPVEWFKCHVPVFDTDPTLAEIFDKVAAKEKREFQSVLGLSNQFLDMEKNGCKIDILPFARQNVFPHHQASDDVTFWAGVQKRIRKSNWRREKSKFEEFESQGKELLQEFISMLPFEFKVNIKEIEDGEKSFLEKRKLKSEKMWANHSERSDIDWKLDHAFLFMKSQYCTKEGKMFTEAKAGQTLACFQHIVLFRFGPMLRAIESAFLRSCGDSYYIHSGKNFFCLDSFVTKNASVFDGFSIESDYTAFDSSQDHVILAFEMALLQYLGVSKEFQLDYLRLKLTLGCRLGSLAIMRFTGEFCTFLFNTFANMLFTQLKYKIDPRRHRILFAGDDMCSLSSLKRRRGERATRLMKSFSLTAVEEVRKFPMFCGWYLSPYGIIKSPKLLWARIKMMSERQLLKECVDNYLFEAIFAYRLGERLYTILKEEDFEYHYLVIRFFVRNSKLLTGLSKSLIFEIGEGIGSKWLSSTSTASSRRSNLQTSKLMLSRPQSFTRMQPFSNQTCLIASKGLNQTSRFPLDLVTASSCLISNCLMTPKLIQSGRKATSTNTYTMESSWLGSKQCCQTLEAWKGESLYMMEPAWIRKEATFARIFSSLSLTVATLVSGQSTVCLPQTQIWPKGLDFVWTLIVHNMNRTLSCLLLTLELHTDASTLQGFWKPKLAIQDGLHRQSAAVKHLNSMRKSRWPSWIADPRCFWKKVHQTCTLKRDCSEVTRLEGHAQFPLKGGQTQGCKKREDLGPSRLELKDLEKMSLEDVLQQARRHRVGVYLWKTHIDPAKELLTVPPPEGFKEGESFEGKELYLLLCNHYCKYLFGNIAVFGSSDKTQFPAVGFDTPPVHYNLTTTPKEGETDEGRKARAGSSGEKTKIWRIDLSNVVPELKTFAATSRQNSLNECTFRKLCEPFADLAREFLHERWSKGLATNIYKKWPKAFEKSPWVAFDFATGLKMNRLTPDEKQVIDRMTKRLFRTEGQKGVFEAGSESNLELEG
What is the function of this protein?
Coat protein: encapsidates the viral genome.  Forms particles of very flexuous filaments, 619 nm long and 12 nm in width, with obvious cross-banding, helical symmetry and a pitch of c.  3. 8 nm.  Synthesis remains unclear: either by cleavage of the ORF1 polyprotein, or by translation of a subgenomic RNA.
What are the official names of this protein?
Genome polyprotein, 241 kDa polyprotein, ORF1 polyprotein.
What are the subcellular locations of this protein?
[Coat protein]: Virion.
Protein: LACB_STRZJ
Sequence: MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPIFGKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNANVIGFGGKITGELLMCDIIEAFIHAEYKPTEENKKLIAKIEHVESHNAQQTDANFFTEFLEKWDRGEYHD
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacB.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: PSRP_PSET1
Sequence: MRTAFYISDGTAITSEVFGHATLSLFPVEFNHKTIPFVETEEKAHQIKELINATAKRDGEKPLIFFTFVNYNLTEIISSANAVCYDFLTTYSEKIEKELNVAPVPKIHRTHSIHEKSYDFRIDAVNYALMNDDGGNIKNYGEADIILIGVSRSGKTPTSLYLALQYGIKAANYPITEDDLETEGLPKCLIPFKHKLFGLTIDPERLAAIRDRRMANSKYASIRQCRIEVREVEMLYKRNRIPFLNSTHHSVEEISAKIISDTDLERRKY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: APT_BOVIN
Sequence: MADPELQLVARRIRSFPNFPIPGVLFRDISPVLKDPTSFRASINLLANHLKKAHGGRIDYIAGLDSRGFLFGPSLAQELGLGCILIRKRGKLPGPTVCASYALEYGKGELEIQRDALEPGQKVVVVDDLLATGGTMCAACELLGQLRAEVLECVSLVELTSLKGREKLGAVPFFSLLQYE
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX3_DICDI
Sequence: MKGFFENLFRQNVRSVINTGKKVGARAAAREIINQEWGYPLANHEVLFLTNVYQPKHMKRHPFHIVRGTVAPLAVTLPLGFFVLNYFGVISSKLGLLIALSSFIGGLVIWTISIIFDSLYDQQHTYEVKRGLVMGMMMFIISEVMFFFSFFWSYFYISLSPNIAIGCVWPPYGLTVYSYMGLPLLNTVLLLLSGAILTDGYTILTEQKAVHEKNEKVLAVEEAFKNLMNLYKTKNSINTLTFVDERRDKFFGKESRQEDKIAEQKLIAISAGVKELRDLDWDLYFFENPENIEPNYKEPTNLSVIEYALITIYLKKRNKVIKTRLYFTLLCAVVFLACQGYEYFFAPFSMNDGIYGSLFFLLTGFHGFHVLVGSILIGIITIRFIVGNFNLLNVGTNFQIYKNKSTGFACTLFYWHFVDIVWIFLYIVIYWWGSR
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YRA2_YEAS2
Sequence: MDKAFDEIIGNSHTDSSSNHKVTRYRRRDLRNELGPRLGFAPSDAASRSKDRLYREREEPPLPKRIRISKIPLDVSDYTLDDMIKEFGSPIFSKIFDNKEDRTCIYEFEDPEVLEKIVERYNGHELHNAKIEVEIYQPQRKHSRMNAHNRRKQTAQEHGRGRPGSHYRQKPNRVSKKNKGREKNNTPTSVEALDAELDAYMKG
What is the function of this protein?
Involved in export of poly(A) mRNAs from the nucleus.  Recruited to the coding sequences as well as poly-A sites of active genes (By similarity).
What are the official names of this protein?
RNA annealing protein YRA2.
What is the protein family that this protein belongs to?
Belongs to the YRA1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: APAH_PROMH
Sequence: MATYLIGDVHGCYRELRQLLNQVNFDANQDTLWLTGDLVARGPDSLEVLRFVKSLGSALKLVLGNHDLHLLGVFAKISRNKPKDKLNELLNAPDADELINWLRRQPLLQVDEEKKIVMAHAGITPQWDLATAKKCAREVEAILSSDSYPLFINSMYGDMPNNWSPELTGLPRLRFSTNAFTRMRYCFPNGQLDMICKDKPENAPAPLKPWFDLPNQLPNDYSIIFGHWASLEGKGTPENIYALDTGCCWGGVLTCLRWEDKRYFIQPSLTHLP
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: NUSB_THEM4
Sequence: MLKSRHKMREAIFKSLFQWDFNKEEILEEISKEHIVSLEPNLQELAVNYLKGIRENIDVIDEIISKYLKNWTLERLSVTDRNILRLGTYELIYVDDIPIEVTLDEMIELGKTYGTENSGKFVNGVLDKIAKAEAPKEKFEL
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RS6E_METMA
Sequence: MANFKVVVSDPKEARAYQIDIKDAEANALIGKSIGDVVDGSIFGLAGYKVQITGGCDGSGFVMKPDLPGPRRQRILTATGVGYVPKLPGQRRRKMMRGKEIAPDIVQVNAKVVEYGSKSIKALLGLETAEEAPAAE
What are the official names of this protein?
30S ribosomal protein S6e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: MURG_SALSV
Sequence: MSGQPKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIDIDFIRISGLRGKGVKALLAAPLRIFNAWRQARAIMKRFKPDVVLGMGGYVSGPGGLAAWSLGIPVVLHEQNGIAGLTNQWLAKIATTVMQAFPGAFPNAEVVGNPVRTDVLALPLPQVRLAGRDGPIRVLVVGGSQGARVLNQTMPQVAARLGDTVTIWHQSGKGAQLTVEQAYAGAGQPQHKVTEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPAIFVPFQHKDRQQYWNALPLENAGAAKIFEQPQFTVEAVADTLAGWSREALLTMAERARAVSIPDATERVASEVSRVART
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CFA20_CHICK
Sequence: MFKNTFQSGFLSVLYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEIEGTNVSTTYITCPADPKKTLGIKLPFLVMIIKNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLSDFTRRAYGTNYIETLRVQIHANCRIRRVYFSDRLYSEDELPAEFKLYLPVQNKAKQ
What is the function of this protein?
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (By similarity).  Involved in the regulation of the size and morphology of cilia.  Required for axonemal microtubules polyglutamylation (By similarity).
What are the official names of this protein?
Cilia- and flagella-associated protein 20.
What is the protein family that this protein belongs to?
Belongs to the CFAP20 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme.
Protein: YDIB_ECO57
Sequence: MDVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPFTYMAFEVDNDSFPGAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIKGKTMVLLGAGGASTAIGAQGAIEGLKEIKLFNRRDKFFDKALAFAQRVNENTDCVVTVTDLADQQAFAEALASADILTNGTKVGMKPLENKSLVNDISLLHPGLLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFTLWTGKDFPLEYVKQVMGFGA
What is the function of this protein?
The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate.  Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively.  It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.
What are the official names of this protein?
Quinate/shikimate dehydrogenase, NAD-dependent shikimate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: YBFI_BACSU
Sequence: MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKGQRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITGSGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFLSSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYMETIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YbfI.
Protein: MSCL_STAHJ
Sequence: MLKEFKEFALKGNVLDLAIAVVMGAAFNKIVTSLVTYIIMPLIGKIFGSVDFAKDWEFWGIKYGLFIQSIIDFIIVAIALFIFVKIANTLVKKEEPEEEIEENTVLLTEIRDLLRAK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MCA_MYCTU
Sequence: MSELRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGERGEILNPAMDLPDVHGRIAEIRRDEMTKAAEILGVEHTWLGFVDSGLPKGDLPPPLPDDCFARVPLEVSTEALVRVVREFRPHVMTTYDENGGYPHPDHIRCHQVSVAAYEAAGDFCRFPDAGEPWTVSKLYYVHGFLRERMQMLQDEFARHGQRGPFEQWLAYWDPDHDFLTSRVTTRVECSKYFSQRDDALRAHATQIDPNAEFFAAPLAWQERLWPTEEFELARSRIPARPPETELFAGIEP
What is the function of this protein?
A mycothiol (MSH, N-acetyl-cysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate and the MSH precursor.  Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.  Activity is specific for the mycothiol moiety.  Has a low but measurable deacetylation activity on GlcNAc-Ins (N-acetyl-glucosaminyl-inositol), and thus can also directly contribute to the production of MSH.
What are the official names of this protein?
Mycothiol S-conjugate amidase.
What is the protein family that this protein belongs to?
Belongs to the MshB deacetylase family. Mca subfamily.
Protein: HUTH_PSEAE
Sequence: MSLHLKPGQLTLADLRQAYLAPVRLSLDPSADAPIAASVACVENIIAEGRTAYGINTGFGLLASTRISPADLEKLQRSIVLSHAAGVGEALDDAMVRLVMLLKVNSLARGFSGIRRKVIDALIALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLIGESRARHRGEWLPAAEALAVAGLEPLTLAAKEGLALLNGTQVSTAYALRGLFEAEDLFAAATVCGGLSVEAMLGSRAPFDARIHAARGQRGQIDVAAAYRDLLTASSEVARSHEKCDKVQDPYSLRCQPQVMGACLTQMRQAAEVLEIEANAVSDNPLVFAAEGDVISGGNFHAEPVAMAADNLALALAEIGSLSERRISLMMDMHMSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAHPASVDSLPTSANQEDHVSMAPNAGKRLWAMAENVRGILAVEWLGACQGLDFREGLKSSPKLEQARRLLRDKVPYYQEDRFFAPDIEAASQLLASGCLNALLPARLLPSL
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALNB_EMENI
Sequence: MPKILCLHGYGTSASILQHQLGPFMAAADPSYEFVFLEGEIECQKAQGLGPFVKGPFLCYNESFAPADIQESCDLIDEMIQAAGPFDGIIGFSQGGSVALSYLLQRQIDGHPPPFRWAVFFSTVIAFAPNDTFGSNILANLTDHEIRLLDGYPATDLSSLHPLTRALCETTAQTFYSAKTGGFISPNTPIAEFSKRDDPSQPRVFHPALLGDRIPIPTVHITGRKDNSLMVGLSVLVQGLCDQRLIRSLTHSGGHNVPRSADDVRAAWAAVDWAIQHSQKQHIW
What is the function of this protein?
Esterase; part of the gene cluster that mediates the biosynthesis of asperlin, a polyketide showing anti-inflammatory, antitumor and antibiotic activities (PubMed:30339758).  The first step of the asperlin biosynthesis is the production of the intermediate 2,4,6-octatrienoic acid by the highly redusing polyketide synthase alnA with cleavage of the PKS product by the esterase alnB (PubMed:30339758).  2,4,6-octatrienoic acid is further converted to asperlin via several steps involving the remaining enzymes from the cluster (PubMed:30339758).
What are the official names of this protein?
Esterase alnB, Asperlin biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the LovG family.
Protein: SPR2D_MOUSE
Sequence: MSYQQQQCKQPCQPPPVCPPKKCPEPCPPLKCPEPCPPPKCPEPCPPPKCPEPCPEPCPPPSCQQKCPPAQPPPPCQQKCPPKSK
What is the function of this protein?
Cross-linked envelope protein of keratinocytes.  It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase.  All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
What are the official names of this protein?
Small proline-rich protein 2D.
What is the protein family that this protein belongs to?
Belongs to the cornifin (SPRR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTREX_MOUSE
Sequence: MADAFGDELFSVFEDDSTSAAGAKKDKEKEKWKGPPGSADKAGKRLDTKLQSESASGGKNKRDLDVEGTDEPIFGKKPRIEDSINEDLSLADLMPRVKVQSVETVEGCTHEVALPADEDYIPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFNNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKYDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEENVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISTVRLYIPKDLRPVDNRQSVLKSIQEVQRRFPDGVPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCERKAQIALDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSSEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLYL
What is the function of this protein?
Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension.  Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT).  NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation.  NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs.  PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation.  The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei.  Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters.  Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5. 8S rRNA.  May be involved in pre-mRNA splicing.  In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand.  Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors.  Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (By similarity).  Plays a role in DNA damage response (By similarity).
What are the official names of this protein?
Exosome RNA helicase MTR4, ATP-dependent helicase SKIV2L2, Superkiller viralicidic activity 2-like 2, TRAMP-like complex helicase.
What is the protein family that this protein belongs to?
Belongs to the helicase family. SKI2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus. Nucleus speckle.