PharMolix/UniProtQA huggingface dataset:
Protein: NU3C_ATRBE
Sequence: MFLLYEYDFFWAFLIISILVPILAFFISGVLAPISKGPEKLSTYESGIEPMGDAWLQFRIRYYMFALVFVVFDVETVFLYPWAMSFDVLGVSVFIEAFIFVLILIIGLVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: LY75_MOUSE
Sequence: MRTGRVTPGLAAGLLLLLLRSFGLVEPSESSGNDPFTIVHENTGKCIQPLSDWVVAQDCSGTNNMLWKWVSQHRLFHLESQKCLGLDITKATDNLRMFSCDSTVMLWWKCEHHSLYTAAQYRLALKDGYAVANTNTSDVWKKGGSEENLCAQPYHEIYTRDGNSYGRPCEFPFLIGETWYHDCIHDEDHSGPWCATTLSYEYDQKWGICLLPESGCEGNWEKNEQIGSCYQFNNQEILSWKEAYVSCQNQGADLLSIHSAAELAYITGKEDIARLVWLGLNQLYSARGWEWSDFRPLKFLNWDPGTPVAPVIGGSSCARMDTESGLWQSVSCESQQPYVCKKPLNNTLELPDVWTYTDTHCHVGWLPNNGFCYLLANESSSWDAAHLKCKAFGADLISMHSLADVEVVVTKLHNGDVKKEIWTGLKNTNSPALFQWSDGTEVTLTYWNENEPSVPFNKTPNCVSYLGKLGQWKVQSCEKKLRYVCKKKGEITKDAESDKLCPPDEGWKRHGETCYKIYEKEAPFGTNCNLTITSRFEQEFLNYMMKNYDKSLRKYFWTGLRDPDSRGEYSWAVAQGVKQAVTFSNWNFLEPASPGGCVAMSTGKTLGKWEVKNCRSFRALSICKKVSEPQEPEEAAPKPDDPCPEGWHTFPSSLSCYKVFHIERIVRKRNWEEAERFCQALGAHLPSFSRREEIKDFVHLLKDQFSGQRWLWIGLNKRSPDLQGSWQWSDRTPVSAVMMEPEFQQDFDIRDCAAIKVLDVPWRRVWHLYEDKDYAYWKPFACDAKLEWVCQIPKGSTPQMPDWYNPERTGIHGPPVIIEGSEYWFVADPHLNYEEAVLYCASNHSFLATITSFTGLKAIKNKLANISGEEQKWWVKTSENPIDRYFLGSRRRLWHHFPMTFGDECLHMSAKTWLVDLSKRADCNAKLPFICERYNVSSLEKYSPDPAAKVQCTEKWIPFQNKCFLKVNSGPVTFSQASGICHSYGGTLPSVLSRGEQDFIISLLPEMEASLWIGLRWTAYERINRWTDNRELTYSNFHPLLVGRRLSIPTNFFDDESHFHCALILNLKKSPLTGTWNFTSCSERHSLSLCQKYSETEDGQPWENTSKTVKYLNNLYKIISKPLTWHGALKECMKEKMRLVSITDPYQQAFLAVQATLRNSSFWIGLSSQDDELNFGWSDGKRLQFSNWAGSNEQLDDCVILDTDGFWKTADCDDNQPGAICYYPGNETEEEVRALDTAKCPSPVQSTPWIPFQNSCYNFMITNNRHKTVTPEEVQSTCEKLHSKAHSLSIRNEEENTFVVEQLLYFNYIASWVMLGITYENNSLMWFDKTALSYTHWRTGRPTVKNGKFLAGLSTDGFWDIQSFNVIEETLHFYQHSISACKIEMVDYEDKHNGTLPQFIPYKDGVYSVIQKKVTWYEALNACSQSGGELASVHNPNGKLFLEDIVNRDGFPLWVGLSSHDGSESSFEWSDGRAFDYVPWQSLQSPGDCVVLYPKGIWRREKCLSVKDGAICYKPTKDKKLIFHVKSSKCPVAKRDGPQWVQYGGHCYASDQVLHSFSEAKQVCQELDHSATVVTIADENENKFVSRLMRENYNITMRVWLGLSQHSLDQSWSWLDGLDVTFVKWENKTKDGDGKCSILIASNETWRKVHCSRGYARAVCKIPLSPDYTGIAILFAVLCLLGLISLAIWFLLQRSHIRWTGFSSVRYEHGTNEDEVMLPSFHD
What is the function of this protein?
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment.  Causes reduced proliferation of B lymphocytes (By similarity).
What are the official names of this protein?
Lymphocyte antigen 75, Ly-75, DEC-205.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: MOAB_BACAN
Sequence: MSVTEHKKQAPKEVRCKIVTISDTRTEETDKSGQLLHELLKEAGHTVTSYEIVKDDKESIQQAVLAGYHREDVDVVLTNGGTGITKRDVTIEAVSALLHKEIVGFGELFRMISYLEDIGSSAMLSRAIGGTIGRKVVFSMPGSSGAVRLAMNKLILPELGHITFELHRQ
What is the function of this protein?
May be involved in the biosynthesis of molybdopterin.
What are the official names of this protein?
Molybdenum cofactor biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the MoaB/Mog family.
Protein: PSAC_TRIEI
Sequence: MSHSVKIYDTCIGCTQCVRACPLDVLEMVPWDGCKAGQIASSPRTEDCIGCKRCETACPTDFLSVRVYLGAETTRSMGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TLX1_CHICK
Sequence: MEHLGAHHLHQGQAEPISFGIDQILNTSEPGSCMVSHPRLQDSADYGLGCIVGSAYNTVTGGYGASGGGAGAYGGTSCSMGALPGSYNVNMAVSMNGNALSSAGGVIRVPAHRPVAGGVHQPLSAAVPPVNGMNSLTGLTFPWMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILMQLQQEAFQKTINQPIQADPICVHNSSLFALQNLQPWSDDSTKITSVTTVASACE
What is the function of this protein?
Seems to be involved in the development of cranial sensory innervation from peripheral ganglia.
What are the official names of this protein?
T-cell leukemia homeobox protein 1, Homeobox TLX-1, Homeobox protein Hox-11.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLYA_SALPA
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLAQGGHLTHGSPVNFSGKLYNIVPYGIDESGKIDYDEMAKLAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGDEELYKKLNSAVFPSAQGGPLMHVIAGKAVALKEAMEPEFKVYQQQVAKNAKAMVEVFLNRGYKVVSGGTENHLFLLDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRIGSPAVTRRGFKEAEVKELAGWMCDVLDNINDEATIERVKAKVLDICARFPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBD_OENAR
Sequence: MTIALGKFTKDEKDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFALIGFMLRQFEIARSVQLRPYNAIAFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: WECF_CITK8
Sequence: MTVLIHVLGSDIPHHNQTVLRFFNDALAATSEHARVFMVAGQDAGLRESCPALSLSFYAGKKTLAEAVIAKAKANRQQRFFFHGQFNTSLWLALLSGGIKPEQFYWHIWGADLYEVSRGLKFRLFYPVRRMAQNRVGCVFATRGDLSYFARQHPRVRGELLYFPTRMDSSLNNMANDRPREGKMTVLVGNSGDRSNEHIAALRAVYQQFGDTVNVIVPMGYPANNDAYIDEVRQAGLALFSAENLHILSEKLEFDAYLALLRQCDLGYFIFARQQGIGTLCLLIQAGVPCVLNRENPFWQDMAEQHLPVLFTTDALNEGVVREAQRQLASVDKSGITFFSPNYLEPWHNALRIAAGEAA
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
What are the official names of this protein?
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase, 4-alpha-L-fucosyltransferase, TDP-Fuc4NAc:lipid II Fuc4NAc transferase, Fuc4NAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 56 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SWP3_ENCCU
Sequence: MVRRSLYFLAVMGVVRSSSGLYIPSVVLQELGIASSQGCLMIAETNNGNFGIVSSGLENPVYITESPQGHREVSWQPVRGEDRAVPIYAPSAEEVRESISSVRGSEPGQYIAPQPTGFVPASTPVFGTIESASTAGAAVPVEGVFVASTENPASTGSSSTSTCPPKGTAGTTDNKGKAGGAAADDKSKSSSSSSSKKKKKGAKSLVALGAVATTALFSIVM
What is the function of this protein?
Spore wall component.
What are the official names of this protein?
Spore wall protein 3.
What are the subcellular locations of this protein?
Spore wall. Membrane; Lipid-anchor, GPI-anchor. Cytoplasm. Note=Is found in the cytoplasm during the proliferative and early sporogonic stages before localizing to cell surface and spore wall in sporonts and spores.
Protein: YBHG_ECODH
Sequence: MMKKPVVIGLAVVVLAAVVAGGYWWYQSRQDNGLTLYGNVDIRTVNLSFRVGGRVESLAVDEGDAIKAGQVLGELDHKPYEIALMQAKAGVSVAQAQYDLMLAGYRNEEIAQAAAAVKQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQATLKSAQDKLRQYRSGNREQDIAQAKASLEQAQAQLAQAELNLQDSTLIAPSDGTLLTRAVEPGTVLNEGGTVFTVSLTRPVWVRAYVDERNLDQAQPGRKVLLYTDGRPDKPYHGQIGFVSPTAEFTPKTVETPDLRTDLVYRLRIVVTDADDALRQGMPVTVQFGDEAGHE
What are the official names of this protein?
UPF0194 membrane protein YbhG.
What is the protein family that this protein belongs to?
Belongs to the UPF0194 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SYD_YERPB
Sequence: MRTEYCGQLNLSHVGQSVTLCGWVNRRRDLGGLIFIDMRDREGIVQVFFDPDHKAAFEQASELRNEFCIQITGTVRARPDSQINKDMSTGEVEIFANTLNIINRSEPLPLDSNQINSEEQRLKYRYLDLRRPEMADRLKSRAKITSFVRRFMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMSADQVREVMEKLVRELWQETKGVDLGDFPVMTFAEAMRRYGSDKPDLRNPLELVDVASLVKDVEFKVFSGPANDAKGRVAALRVPGGAQLSRKQIDEYGQFVGIYGAKGLAWLKVNDRAAGLEGVQSPIAKFLSAEVLDAILVATQAESGDILFFGADSYKIVTDAMGALRLKVGRDLELTRLGTWAPLWVVDFPMFEDDSEGGLTAMHHPFTAPKDMSPEQLAAAPTTAIANAYDMVINGYEVGGGSVRIHRTEMQQTVFGILGITEDEQREKFGFLLDALKFGTPPHAGLAFGLDRLVMLLTGTDNIRDVIAFPKTTAAACLMTDAPSFANPASLQELSISVVAKKGTTDAGAEENQ
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_OLEA2
Sequence: MLLSLNWLREFVPYTGTAQELGDRLTMLGLELEEIIRPFDAIADIVVGHVLECGRHPEADKLSVCRVDVGTEVLDIVCGAPNVAAGQKVPVAKVGVTMPSGLKIKKAKLRGQPSCGMICSESELELSDESDGIMVLPQDSVPGVRLVDLLQLDDTVLDISITPNRADCLSVLGLAREVALAFDLPLTMPQLELREQGEDAGSDVTIAIADGAQCPVYQGRIIEGISTCPSPLWMRHRLKSVGVRPISAIVDVTNYILMELGQPLHAFDLDLLEGARIVVETAAEGERFTTLDGQERVLKASDLLIRDGAKAVALAGVMGGANTEINDASRRVFLECAVFKPATIRRTARRLGLSSESSYRFERGVDQVLSTFAMNRAAQLMCELSGGVLRPGVCRAEPAPWQAAQLRFRPARAAALLGISLDDGFCRETLQKLGCTLSGADTPEWTVTAPSHRHDLEREADLIEEVGRVYGMDNIPPVLPKVSKPLEQGRTDSEYEFWARIKAWGRGLGLNEAVNYSFVGHKDLDFLGLPAGNRISIMNPLTSEQDVLRTELAPGLLNTLRHNLAQGSTGLQVFELAHIFEADQSSDTTARESGRLGLLVYGQRYQDGWPRREEDAGYEDLKGIVEHLLRVLNLGPAAFTLRKDHSWLLPCVEIRVGSVCAGVAGRVKPDIADAYHARKDVWMAEIDLDALRTLCRDVAVQFSALPVFPPVKRDITVMAPASVPVSAVTDHVRGMSLKLFSDIVLVDVFEPETPEGGTPERNLTFRLTFRHAERTLKDKEVDKERDKVAESLTEALGVRI
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SENP7_RAT
Sequence: MDRARPGRRRASSEIVTEGKRKKSSPADLQKITKLLTVKSEDVLAQSPLPKLRGSECWWTRSLRNKVICLDHKTTKAAHGCPPKALPKRHLKVMLTNVLWTDLGREFRKTLPRNDAKLCDTSKVQSDSLPSTSVDSIETCQRLDPLHQSLNLSERIPRVILTDIRQTELGRKYLKIPSVTEASLSDTASPKSEELSSSADGSLESCQNVNHLKSFLSERGSKPSRTGDISAKEAANGRQEQGDDGDIAPEMVTPQSKDFNSGNKGDYHEEGTSNKNTSYSHSETDHTPVSRKRKKRGRSNFHNSHNPKSSVDKSTEYIKEEENESTVSSKLEESNEDSHQDPAPPEGLTPDSLETEATNVCSFVVQEPDVSAASGRACSPNKSSESSVSSEVAENSSAAEKGEASTVKEAPPPGGNSEENQLLMSAEPIVVSSDEEGPVEHKNSVILKLQPSQDYEFMSENQTTSDPQLSELMLGACESVQVSSELCPYNPDMENISCINPNSEMDLKLDFIFTCVYIGKIKGTSKGCITFTKKYIKIPFQVSMNEISLTVDTARLKRFGLWESKDDDHSKRSHAILFLWVSSNYLQDIQTQLENPMLSQQSKANEFIFLELNSPISQREELKLKDIMMEIGATNGELQLSCPLPWVQAFPLFQDLSPQEISFLHYYCASASSFPAVAGADMKKKPVSQPSNADVVKPTYTFLHKQSSGCYSLSITSSPDEEWREVRNTGPVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLLLEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPDLSVAQRRHRRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQEFQDQQSQHDNKTIDNDPHTTSTVFTSAEESQSTETSMSVPKKMCKRPCILILDSLKAASIQNTVQNLREYLEVEWEVKRKTHREFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFQDPIVNFELPIHLEKWFPRHVIKTKREDIRELILKLHLQQQKGSSS
What is the function of this protein?
Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS.  Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity).  Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1.  Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains.  Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity).
What are the official names of this protein?
Sentrin-specific protease 7, SUMO-1-specific protease 2, Sentrin/SUMO-specific protease SENP7.
What is the protein family that this protein belongs to?
Belongs to the peptidase C48 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NO40_SOYBN
Sequence: MELCWLTTIHGS
What is the function of this protein?
Modulates the action of auxin, and may function as plant growth regulator that alters phytohormone responses.
What are the official names of this protein?
Early nodulin-40.
Protein: Y1551_VIBVU
Sequence: MSKNQLPSYQVVADEMKMATLAVTPAELHGLLAGLISGGLSQQDQSWQPMLFDYTNDGMGWPSAALEQAQALFNVTSAQLTSDEMVLNLLLPNAEGEEAIFALADALSDWVNHYISGLGLAGAAFNKASEEAKEALADLEEMARLGVDEDDDLQEQAELLEQVIEHVKACTLLIHAEFGAKTSSSETPTIH
What are the official names of this protein?
UPF0149 protein VV1_1551.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: NUOB_CAUVC
Sequence: MGVIVPGNSSPVPALSAGRSTVEGYDPKLHDPFFDGVSQQLADKGFITAAADDLITWARTGSLMWMTFGLACCAVEMMQASMPRYDLERYGFAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYYYSYSVVRGCDRVVPVDIYVPGCPPTAEALVYGVLQLQKKIRRTGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RU1C_CHICK
Sequence: MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFSAPPPGGAMIPPPPSIPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPSRPMMVPTRPGMTRPDR
What is the function of this protein?
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome.  SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing.  The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.  Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
What are the official names of this protein?
U1 small nuclear ribonucleoprotein C, U1 snRNP C, U1-C, U1C.
What is the protein family that this protein belongs to?
Belongs to the U1 small nuclear ribonucleoprotein C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MUG43_SCHPO
Sequence: MNNITRDIYTKGQPADLKRLLMKRNSFRRPLLNMRCNSVLQYSLEKRKLTVQDLKDTRMELNNMIRILTEAMAAHEWTVDNVNIADIQSLQSTIHSTLKNFQKINVLQLNINASDNSLAYLSKPEESYNFLTIYFSTLLSYEKVENLIKKSLTVIDSLYGLLNYQINAQHSLGCIPLNQDSFKQLKLLICILEEDIKLDDCGLEISASKNEYLEKIKTHYKTWLRIHTFLTLFPVPSVLSSNLKKQMYGWFEDLRDESLKSIILASLSE
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 43 protein.
Protein: RL2_EHRRW
Sequence: MGIKNLNSVTPSLRGTVLLDKSTLWKGRPEKSLVGYKISHGGRNSRGVITVRHRGKGHKRLYRIIDFKRKKVGVPATVERLEYDPNRTAFIALLSYDDGEKSYIIAPHGLKKGDVIMSGNGSDILPGNCLMLKLIPVGTFVHNVELRPGGGGIIARSAGTYAQLMSKDGIYVLLRLSSGEIRKVLADCCATIGIVSNLDNQNVKLGKAGRSRWLGIRPTVRGVAMNPIDHPHGGGEGKTSGGRNPVTPWGVSTKGKKTRKKNKSSNKYIKRVSDKG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: Y1324_MYCTU
Sequence: MTRPRPPLGPAMAGAVDLSGIKQRAQQNAAASTDADRALSTPSGVTEITEANFEDEVIVRSDEVPVVVLLWSPRSEVCVDLLDTLSGLAAAAKGKWSLASVNVDVAPRVAQIFGVQAVPTVVALAAGQPISSFQGLQPADQLSRWVDSLLSATAGKLKGAASSEESTEVDPAVAQARQQLEDGDFVAARKSYQAILDANPGSVEAKAAIRQIEFLIRATAQRPDAVSVADSLSDDIDAAFAAADVQVLNQDVSAAFERLIALVRRTSGEERTRVRTRLIELFELFDPADPEVVAGRRNLANALY
What are the official names of this protein?
Uncharacterized protein Rv1324.
Protein: SECA_RENSM
Sequence: MPSLFEKILRTGDRKTLKRLHVYADAINTLEDSFQTFTDAELREETDKLRARHADGESLDDLLPEAFAAVREGSRRTLGMRQFDVQLMGGAALHLGNIAEMKTGEGKTLVATAPAYLNGLSGKGVHIVTTNDYLASYQSELMGRVHRFMGLTSGCILSAQEPSERRLQYAADVTYGTNNEFGFDYLRDNMAWSSEELVQRGHHFAIVDEVDSILIDEARTPLIISGPASGDANRWYGEFAKVVLRLDVDDDYEVDEKKRTVGVLEPGIEKVEDYLGISNLYESANTPLIGFLNNAIKAKELFKRDKDYVILDGEVLIVDEHTGRILAGRRYNEGMHQAIEAKESVEIKAENQTLATVTLQNYFRLYEKLSGMTGTAETEASEFMGTYELGVVAIPTNKPMVRIDQSDLVYKNEVVKFEAVVKDIEERHKEGQPVLVGTTSVEKSEYLSKQLSKLGIKHEVLNAKNHAREASIVAQAGRKGAVTVATNMAGRGTDIMLGGNAEFNAVTELAKRGLDPEETPEEYEAAWAEAYEKAQEATEEEHEEVVELGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLTDDLMRLFNSGAAERLMGRSVMPDDQALESKLVSKAIASAQGQVEGRNAEQRKNVLKYDDVLNRQREAIYGDRRRILEGDDLHEKVQHFLEDTVNESIDATTAEGHAEGWDYKALWSSLGTLYPIGLTADDVAEEVGGLANVTSDVLKREILSDAKLAYQGREEKLGSETIRELERRVVLSVIGRKWQEHLYEMDYLKEGIGLRAMAQRDPLVEYQREGFVMFQAMMGAIREESVGFLFNLEVQVEEAPAASAGVQANQPSALLDRVNGEDAGAEAHASAKPVLNAPGLAEPERPSQLQFTAPDASGEAETRIERRSTAGSAGDSNLPPSARKTNKPAPKRKKRR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: EPS15_HUMAN
Sequence: MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
What is the function of this protein?
Involved in cell growth regulation.  May be involved in the regulation of mitogenic signals and control of cell proliferation.  Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR.  Plays a role in the assembly of clathrin-coated pits (CCPs).  Acts as a clathrin adapter required for post-Golgi trafficking.  Seems to be involved in CCPs maturation including invagination or budding.  Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
What are the official names of this protein?
Epidermal growth factor receptor substrate 15, Protein Eps15, Protein AF-1p.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. SUBCELLULAR LOCATION: [Isoform 2]: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes.
Protein: MT1_CRIGR
Sequence: MDPNCSCSTGSTCTCSSSCGCKDCKCTSCKKSCCSCCPVGCSKCAQGCVCKGASDKCTCCA
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
What are the official names of this protein?
Metallothionein-1, MT-1, Metallothionein-I, MT-I.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: FABZ_SALHS
Sequence: MTTNTHTLQIEEILELLPHRFPFLLVDRVLDFEEGRFLRAVKNVSVNEPFFQGHFPGKPILPGVLILEAMAQATGILAFKSVGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVTFEKTRRGLTRFKGVALVDGKVVCEATMMCARSREA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.