PharMolix/UniProtQA huggingface dataset:
Protein: SLN14_MOUSE
Sequence: MPYAEITVNLGKVTLGEENRKKMTNSCLKRHENSSLVQAVCALLNSGGGVIKAEINDKSYSYRCHGLGQDLETSFQKLLPSGSQKHLDYMQQNHDLLIFVKSWSPDASSLPLRICSLRSNLYQRDVTSAINLCANGALELLREKESRAQRGTPRLHSQDHILNRTIQEEEDIKMCALEFLKKDKLNFKEKLSFTESTHVEFKRFTTKKIVPRIKETLAHYVSAFANTQGGYIIIGVDDKSKEVFGCKKEKVNPDSLKTEIKNCIEKLPTYHFCREKPKVNFTTKILKVYQKEALYGFVCVVQVEPFCCVVFAEDPDSWIMENNIVTRLKVQQWVEMMLDIQSDPSSGFPTINDSAHLMTPALSAPRRPAYLTKVLEHKETLQRHFFSVTQENLQFQPESLCKKLFSDHEGLEDLLKAQTHPCSHGIVIFSRSWAGDIGLMREEKVLCDALLVAVGSPLVLYTILTDPSSTGRADYTQNTALQLKRQLQTLGGYPGKICVIPRVIYLASRGSRPDQPPVYYPRPYTLSSKAEVEDLLQGLVLVSLCSRSVLSDQLGCEFFKQCLEEQANTLSRNLQESRELFIHCLPGTRKTALAIKMVEKIKDVFHCKPKEILFVCENDSLRDFVMQQVTCRAVTRRTFMREEFPKIKHIVMDETENFCSRHGDWYVKAKSTTHPKANGAANEHPHHGILWLFLDPFQVRHADGSGLPVPSAQFPRKMITSEIHCAVEIAKVMKDEMKRMQENPPSMGLPDTLATFQEAPYEEAMRAGALPGVCEIKANLTPEQIANYVAEKCHSLFHEGYLPQDIAILYRRREDRGQYKDVLLKAMARGTTEVAFNSAADVCADGIILDSVEQFSGMVRNIVFGLCPESVHSEGVHKLCFASKAIKHLYLLYGGRTAF
What is the function of this protein?
Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083).  May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable).  Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner.  Involved in correct maturation of megakaryocytes and especially important for proplatelet extension (By similarity).
What are the official names of this protein?
Protein SLFN14.
What are the subcellular locations of this protein?
[Protein SLFN14]: Nucleus.
Protein: GCT22_ARATH
Sequence: MVMWVFGYGSLVWNPGFHYDEKVLGFIKGYKRVFDLACIDHRGTPEHPARTCTLEKAEEAICWGTAFCVRGGPEKERLAMEYLERRECEYDLKTSVDFYKEDDPLKPAVTGVIVFTSTPDKVSNKYYLGPAPLEDMARQIATANGPCGNNRDYLFLLEKAMHDIGHEEDYVIELANEVRKVLAESSTKKVTPVKESRASRVANKSKNNVPTAHQILPHHPEAVATTI
What is the function of this protein?
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and plays a significant role in glutathione (GSH) homeostasis.  Converts GSH to 5-oxoproline and cysteine-glycine (Cys-Gly) dipeptide in vitro.  Possesses low activity towards gamma-glutamyl-L-alanine.  Has no activity towards gamma-glutamyl-L-cysteine.
What are the official names of this protein?
Gamma-glutamylcyclotransferase 2-2, AtGGCT2;2, Gamma-glutamyl cyclotransferase 2;2.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamylcyclotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_STAA9
Sequence: MLKPIGNRVIIEKKEQEQTTKSGIVLTDSAKEKSNEGVIVAVGTGRLLNDGTRVTPEVKEGDRVVFQQYAGTEVKRDNETYLVLNEEDILAVIE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_AGARV
Sequence: MARSLKKGPFADESLLKKVDAMNASGDKSVIKTWSRRSTIFPSFVGHTIAVHDGRKHVPVYVTEDMVGHKLGEFVATRTYRGHGKDEKKSGVR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: Y1470_HAES1
Sequence: MSDIAITICILALVAVIGLWIGHWKIRGVGLGIGGVLFGGIIVAHFMNQNGLKLDAHTLHFIQEFGLILFVYTIGIQVGPGFFASLLSAGLKLNGLATLIVVLGAVSVFVLYKVVNVDLDIILGIYSGAVTNTPSLGAGQQILTELGIENANSTMGMAYAMAYPFGICGILLSMWLIRLFFKIKVEEEEKQFQKASGQDKESLTTVNVKVTNPNLSGLRLIDIPGFDNKDVVCSRLKRQENISVPSADTIIAIDDVLHLVGEINALKKMKLVIGEEIDMPMTHLAGDLRSERIVVTNEKVLGKRIKHLGIHKKYGVVISRLNRAGVELVPTANTALQFGDVLHIVGRSDTIGNATSIIGNAQQKLQQVQMLPVFIGIGLGVLLGSIPFYIPGFPVALKLGLAGGPLVVALILARIGSVGKLYWFMPPSANLALREIGIVLFLAVVGLKSGGGFVDTLVHGQGLEWMGYGMFITFIPLMITGIIARLYMKLNYLSLCGLLAGSMTDPPALAFANAIKEDSGIAALSYATVYPLSMFLRIMSPQLLAILLWTAM
What are the official names of this protein?
Putative transport protein HS_1470.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROQ_SACD2
Sequence: MATILVLHGPNLNLLGTREPEIYGATTLADINSTLTEMCIAKGHHLQALQSNAEYELINRIHDAKGEGINFIIINPAAFTHTSVALRDALAAVDIPFIECHLSNVHTREAFRHHSYFSDLAQGVICGFGAQSYELALQAAFAKLDS
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RL35_MESH7
Sequence: MSKIKFKTKSALKKRIKVTGTGKVKHGHAYRSHLAQSKTTKQKRQSRKSTLMNNSDFKRLKKLI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: DBR1_DROME
Sequence: MKIAVEGCAHGELERIYDTIEGIEKVGGTKIDLLLCCGDFQSTRNLEDLQTMAVPKKYLDMCSFYKYYSGELVAPVLTIFIGGNHEASNYLQELPYGGWVAPNIYYLGYAGVVNVNGVRIAGISGIFKGHDFLRGHHEFPPYTDSTCRSVYHVRQLEVFRLKQISGRVDIFLSHDWPTGIYEYGNKAQLLRKKPFFAADMESGKLGSQPLEELLKAVQPAYWFAAHLHCKFAALVPHNHSQKLGDAESSSSSSSSEDEDEEREKVKKAAPVPPPSKSVPVTKFLALDKCLPRRAFLQVVEVPSDPIEGTPRLEYDAEWLAILHSTNHLISVKENYYYLPGKKAGEFTERSNFTPTEEELEAVTAKFQKLQVPENFERTVPAFDPAEQSDYKHMFVDQPKVQLNPQSNTFCATLGIDDPLCLVLLANGLDLPAVGATECKDRETKSSKLQAVEEDVAEPLVTPTKRKLNLSLPAPTTAAADTTDENVIDLPEEEAEEAIIATETPHVEEPASVPASPNVKKLKRRNQNIYQAQED
What is the function of this protein?
Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded.  It thereby facilitates ribonucleotide turnover.
What are the official names of this protein?
Lariat debranching enzyme, DmDBR1.
What is the protein family that this protein belongs to?
Belongs to the lariat debranching enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PURL_STAA1
Sequence: MSKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHSKPFLKQFPTSGEHVLMGPGEGAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSLRFGELDNKQNQRLLKGVVKGIGGYGNCIGIPTTAGEIEFDERYDGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESKRPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQVPTREPGISPYEMMLSETQERMLLVVEKGNEQKFLDLFDKHELDSAVIGEVTDTNRFVLTYDDEVYADIPVEPLADEAPVYILEGEEKDYNTSKNDYTHIDVKDTFFKLLKHPTIASKHYLYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAYRNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNETKGTSIFPTPVVGMVGLIENVNYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHEFESLDLSSEVEKGESIKTAIREGLLSHVQTVGKGGLLITLAKLSAHYGLGLKSSIDITNAQLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGAIAQCLTTQD
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGSA_LISIN
Sequence: MHIALIAHDEKKDLMVGFATAYKHLLEPHQLYATGTTGLRIIEATGLTVHRFKSGPLGGDQQIGARISENKMDLVIFLRDPLTAQPHEPDVSALIRLCDVYEIPLATNIGTAEILIRGLGAGFLDWRDLRRNDE
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: S12A4_MOUSE
Sequence: MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAEREDSDGQGNHRENSPFLCPLDASRGNDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGGRRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGTHDMSSATLNNMRVYGTIFLTLMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTVVVDNETVATRLWTFFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAAGVLQENLWSAYLEKGEVVEKHGLPSTDTLGLKESLSLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWTLSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMDIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLDGHIDVWWIVHDGGMLMLLPFLLRQHKVWKKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERDREAQLVKDRHSALRLESLYSDEEEESVAGADKIQMTWTRDKYMAEPWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPKNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
What is the function of this protein?
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:11551954).  May contribute to cell volume homeostasis in single cells.  May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (Probable).
What are the official names of this protein?
Solute carrier family 12 member 4, Electroneutral potassium-chloride cotransporter 1, Erythroid K-Cl cotransporter 1, mKCC1.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GP169_BPPH2
Sequence: MSVQLNAFTFILERRGWRMVCYEQLTTNGTRILHFYLKDNPTFFATYSSQFLSDTKMIRRFASWSGQLLEGSNSVFWTNITPFEPIDEETAEDIKNLDKVVEGMNFTL
What are the official names of this protein?
Gene product 16.9, gp16.9, Protein p16.9.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus gp16.9 family.
Protein: RL22_MYCPA
Sequence: MTTTEFPSAVAKARFVRVSPRKARRVIDLVRGRSVTDALDILRWAPQAASEPVAKVIASAAANAQNNNGLDPATLVVATVYADEGPTAKRIRPRAQGRAFRIRKRTSHITVVVESRPAKDQRSAKSSRTRRAEASKAAAKAPAKKAPAKKAPAKKAPAKTAAKKAPAKTSETSDAKGGSD
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: MCA3_PLAF7
Sequence: MVYNNGSLRGRKKIEEKYIPMNRKSTSLKDPSRTKNNNYIKTLDTYINEEDSPTKILSKGKKNKNENIKKRINEKDNDTDREDAASLNVDYNKNVMKKYNTRGTFIEKVSSSERNIEHNNNIIRKLGSKDYSKARVQTMTTNIGNHNALKKINPKVPSITSRTKSYTKVMNENKYNNNNSNNSNNNNINSMYYSKKLNNKKYSTEHTQSIDNNNITSKRLNNKKTATDKAQSTSRYCISNSVKKSYSTKGYNTDRSQTMSRYTLQNKKDSNTNTNRKGYSTHRGQIIQDNSNINNQAEKKKRNMSLKKKYIKESSNSTITGSNEKKNSNNILKKNSTCDLNYLNKEYNNNNNMHEHAENVYNINDNEGCSSMQIINDEDVQKNVPEFYTINLGSETKNMGENYIFKNRDKKIKPNIYNERNNMDLMEHKLNDDMSYNFADHIKDIECYINQLNESNKCNIYKECDPSKLISPVYDNVNDNILENNQQLNEYEKHNDILTTSYLKYYSHTNNNNHYYNDEDVHLDLGKTNEGFSNVVKNMDNIPWNETNKKESFSNIKKKIDHTDDRHIAYVDNSSMKHTMNDKDQYVKNVPYNNTMEEVLLLNEKRGNILGSLISKNHDAKRATSNNNNINNNKYYYYDNKYSEHGGDSVSSNIGYPHGYKNNNIYNYVNNIKDLSSPLYCNTKTKRAHKFHTDNIMSDQLNKYEDNNKNDGKFFSGNISSKQKGKNNLTNYTTHSSEYRIKSIESNLTKDYRKSLTYNDIPNFLDYNINNTNVQNSDFGDSHYINRNVSYKNSMNSNDDIQNSNNNNNNNNNNNMVNNPNEYLVYTNEKHYVRINNKLYEKTRDNTYIEVDSNSNFDIINDINSSHNSPLDNIKDNTLYHNTNKKEYSDYVSSYSNINKYEDINLPNNIHVSKDGKYLFKNYSVSQNVSDDNSVQDSFFSRTERSNSQNRYDKNGVNHIEQNYYNNSNRRDDIYYYHNQLKKLERLTQQNIKSGKYQRNIPQNDDNDHNDDDSEIKEVKKDKTKIDMNKHLHLNDKKIFNQVKRENTGVHMNASKTIKNMKEVTYRNINNDTNYNNNNVKINYLYSDELGKNKNRDTPLKTKQHGDSLDNKTELKKKIYNDIINNDIINNNIINNDIIKSGAINNNIVNNNLINNYNADNRNVSNSIFTQHINNINNNFYNSDDERINIIDNNKRMDMTKDESDRFRNNYFVELEKRKKNLGKTNNTTPISLSKNETINNMMINKRNFFNNYISDKVRDKILKREISCSVNTVCSSKTNNKTNSNYSSNNNNDNNNNNNNSNPFILDNSIRKSNIIITTSNNAKLINNTIISKGINNNILNINSNKNKSLNSAKINALGLLSSRNDLNYIMNNNRTSNNHINQHLLYNNRNYSVIKIPNVHKEKRSSKIPHNINIKSNLNLEPNIKTYTNIKTPINIKAYTNIKAPTNIKAPINIKASTNIKAPTNVKAPTNVKAPTNVKAPTNVNAPTNVNAPTNANAPTYVNTPTNIKRQEFSNVTLNYKGISKFDINEDKNTTIIPPLHRQSNSNFPFKNTKLNLNSDMYTEKELIKCKSINNSDIYNYLRNTYNKTPSKFYRTVSYRNMSLKKNKSMLENRKRKTEKKEENLMSTFNYTSEVDSKYIVKKAVVVGCNYVSEERSRLYGSVNDAYVFCRALVKYFDFLPENILLLTDSLPSNAYIYEDFDINRKKYINVDEEENIKNNEPLKKKNIFNLFNTNALYTTLKKTNEEELNCNSCKDVEIKNVDISSEKMNFNLWPTRVNILKAVNWLVRDSIPFGSYVFYFAGKSVQVDNMSGWEGEGYDEAFLCSDPFNKISEHNVITAVQLKDLLLSINESAQMTIILDCSGGQTILDPAGTENSLSYIKGCKQKGIWPITNPTNKVHKAIYDITILNNTSMKKYFCRSRYSKLIEVESTSAMIDPLLQSISSLPVAPKAYCLCAATWEQISIEGLFPIIEFARVSQLKKPESYKTGEGHYQNMNKKNIRAEKSNRNGPNGLINKNNNLSKKTNYEKNFNFTLNMMKMLFSNTNNNENKLDEKEKINRLGFNENDSDYIDDNYNSDDNNNNNYYYNYDGEKGFKNFQENLNNVGQKDVIKNKKFKDNYILVSHGVFTYCLIEAIIEFKEKELKYNILEKKNEQFIPMTLKNLINVIQQKMQNIKYNKLKKINQKPEFTIHPGANATNNNYFVHYSKNIHFQNYKCNFINADLSPFLNVNKAWEEINRTTLRNRKSLSLSSTLINTASSKYFTQKNEQFKNSYSLKY
What is the function of this protein?
Protease that cleaves specifically after arginine or lysine residues.
What are the official names of this protein?
Metacaspase-3, PfMCA3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.
Protein: CDC73_MOUSE
Sequence: MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF
What is the function of this protein?
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways.  May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.  Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.  PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.  PAF1C is required for transcription of Hox and Wnt target genes.  PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1.  PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3).  PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription.  PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors.  Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling.  Involved in polyadenylation of mRNA precursors (By similarity).
What are the official names of this protein?
Parafibromin, Cell division cycle protein 73 homolog, Hyperparathyroidism 2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the CDC73 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRGR_HUMAN
Sequence: MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
What is the function of this protein?
Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
What are the official names of this protein?
Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. SUBCELLULAR LOCATION: [Isoform A]: Nucleus. Cytoplasm. Note=Mainly nuclear. SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion outer membrane.
Protein: USPB_VIBVY
Sequence: MINGDIILFALMVVTGVNLARYLTALRSLIYIMREAHPLLYQQVDGNGFFTTHGNVTKQVRLYHYLKSKEYHHHHDEVFTGKCDRVRELFVLSVSLTGVTLLAAFLL
What are the official names of this protein?
Universal stress protein B homolog.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DHPS_STAAU
Sequence: MTKTKIMGILNVTPDSFSDGGKFNNVESAVTRVKAMMDEGADIIDVGGVSTRPGHEMITVEEELNRVLPVVEAIVGFDVKISVDTFRSEVAEACLKLGVDIINDQWAGLYDHRMFQVVAKYDAEIVLMHNGNGNRDEPVVEEMLTSLLAQAHQAKIAGIPSNKIWLDPGIGFAKTRNEEAEVMARLDELVATEYPVLLATSRKRFTKEMMGYDTTPVERDEVTAATTAYGIMKGVRAVRVHNVELNAKLAKGIDFLKENENARHNFS
What is the function of this protein?
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate, the immediate precursor of folate derivatives.
What are the official names of this protein?
Dihydropteroate synthase, DHPS, Dihydropteroate pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the DHPS family.
Protein: VE6_HPV30
Sequence: MAFKFENTGERPRTVHHLCEVQETSLLELQLQCVYCKKELSSSEVYNFACKDLRLVYREDSPYAVCNFCLLFYSKVRKIRHYNYSLYGASLVALTKKELFDLLIRCYRCQQPLTPEEKQLHCEYKKRFHRISRTWTGLCLQCWRHTTSTETAV
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation.  In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development.  The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).  The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization.  Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis.  E6 also inhibits immune response by interacting with host IRF3 and TYK2.  These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: RL24_VIBVU
Sequence: MAAKIRRNDEVIVLAGKDKGKKGKVTKVLATGKVIVEGINLVKKHQKPVPALGIQGGIVEQEAAIDVSNVAIFNAATGKADRIGFRFEDGQKVRFFKSNGETVSN
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: 3SX2_DENPO
Sequence: LKCFQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSSSCSETENNKCCSTDRCNK
What is the function of this protein?
This three-finger toxin inhibits ASIC channels.  It acts as a gating modifier toxin by decreasing the apparent proton sensitivity of activation and by slightly increasing the apparent proton sensitivity for inactivation (PubMed:24695733).  It binds more tightly to the closed state and to a much lesser extent the inactivated/desensitized state of ASIC1a isoform of ASIC1 (PubMed:24695733).  It interacts directly with the outside surface of the thumb domain of chicken ASIC1a (ASIC1a), but does not insert into the acidic pocket as suggested previously (By similarity).  This binding leads to relocation of the thumb domain that could disrupt the acidic pocket of cASIC1a (By similarity).  The peptide exerts both stimulatory and inhibitory effects on ASIC1a (PubMed:24695733).  It reversibly inhibits rat ASIC1a (IC(50)=21-55 nM), rat ASIC1b (IC(50)=103-192 nM), rat ASIC1a-ASIC1b (IC(50)=72 nM), rat ASIC1a-ASIC2a (IC(50)=246-252 nM) and rat ASIC1a-ASIC2b (IC(50)=61 nM) (PubMed:23034652, PubMed:23624383, PubMed:24323786, PubMed:24695733, PubMed:26991634).  In vivo, it shows a potent naloxone-resistant analgesic effect against acute and inflammatory pain upon central and peripheral injection (By similarity).  In addition, it also has an opioid-independent effect on both thermal and mechanical inflammatory pain after systemic administration and is effective against neuropathic pain (By similarity).
What are the official names of this protein?
Mambalgin-2, Ma-2, Mamb-2, Pi-Dp2.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Mambalgin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.