PharMolix/UniProtQA huggingface dataset:
Protein: LPXH_SHELP
Sequence: MNYTLFVGDLHLSADRPDILNAFHQFLDQDASHCDALYILGDLFEVWVGDDIAEPFALELAERLKRFSTHTPIYFIHGNRDFLLGKEYAKRSGMTLLPEIYSIDLYGEPSVLLHGDSLCTLDKAYQRFRRFRNMAWAKFIYNHLPKSKRIAIADKLRSKSKQSNQIKSYSIMDVEQSAVEQLMAETGAKRMIHGHTHRPDIHRLANDTQRIVVGDWYEQGSVLKISPKEVNLQSLPFGETEA
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: P3F1B_XENLA
Sequence: MAATAQYLPRNNSLPSNPLMHPDSDRMHQGTTYREVQKMMHQEYLQGLATNAGHPMSLTHHQWLPNPTSDWGSGSHLGAQAEHGKSGVQSSREDLSSSFHHHRSHLVHQQTPSSHAWAQSGGHHLPSMSPGSNSHQPLIYSQSSYTNLNGMLGPQASSLHHSMRDPLHDDPGVHDTHVESPPQHLGHHQDHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETDSTTGSPTNLDKIAAQGRKRKKRTSIEVGVKGALENHFLKCPKPSAHEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPAGVPHPPMEDVYSQAETPPLHHTLQTSVQ
What is the function of this protein?
Acts as a transcription factor (By similarity).  May play a role in neuronal differentiation (By similarity).
What are the official names of this protein?
POU domain, class 3, transcription factor 1-B, Homeotic protein NRL-34, XlNRL-34, Homeotic protein NRL-34-A.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL23_DESPS
Sequence: MKNIYGVLKGPVLTEKAAILQEIDGQVVFKVHPKSNKIEIKRAIELMFDVKVKDVRTASMRGKEKRVGKTVGQTKEWKKAYVSLAEGEINFTDEI
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: ARV1_CANAL
Sequence: MICIECGYSNIDCLYSKYKSDYIKLSVCPECNKIADKYIEYDSVILFLDILLLKRQAYKHLAYNLTEMEMEIGSSTNFHINDNTNFKFFHTYRKLMKLIFMILSFEVYLTWANEEKLLIHSQLINLIFNQSVVYQYLFFIIKSSLENLILNLSLQLILRLGYKWGQGPQKINGNIRDKELFGYKTSVLLVTTMVSGSIRLFPILMFIWPYDNISITKPLINLIAFINIVEALRVVTSLGYVELILSLAFSIVIRNIVSKSLLVLIVRLFLDFNFTEVYYNEMYQLYSQIQTYIRWI
What is the function of this protein?
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.  Regulates also the sphingolipid metabolism.  Required for growth during anaerobiosis and sterol uptake.  Plays a role in pathogenesis.
What are the official names of this protein?
Protein ARV1.
What is the protein family that this protein belongs to?
Belongs to the ARV1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: RSBW_STAAT
Sequence: MQSKEDFIEMRVPASAEYVSLIRLTLSGVFSRAGATYDDIEDAKIAVSEAVTNAVKHAYKENNNVGIINIYFEILEDKIKIVISDKGDSFDYETTKSKIGPYDKDENIDFLREGGLGLFLIESLMDEVTVYKESGVTISMTKYIKKEQVRNNGERVEIS
What is the function of this protein?
Negative regulator of sigma-B activity.  Phosphorylates and inactivates its specific antagonist protein, RsbV.  Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
What are the official names of this protein?
Serine-protein kinase RsbW, Anti-sigma-B factor, Sigma-B negative effector RsbW.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: SURE_SYNS9
Sequence: MAPLRILISNDDGVFADGIRTLAAAAAARGHEVTVVCPDQERSATGHGLTLQSPIRAERADELFAPGVTAWACSGTPADCMKLALFELVKHKPDLVLSGINHGPNLGTDVFCSGTVAAAMEGTLEGIRSLAVSSACFQWRQFQAAADLAMDVSEQAIHGNWPENMLLNLNIPPCAKEVMGPLRWTRLSIRRYDEQFSSRKDPRGRAYYWLAGEVVNDLESAGEGPKDWPSDVAQIHKNCPSLTPIQPDLFWRGPLGDLPQLKLNDQSVH
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_SACEN
Sequence: MRVLAAMSGGVDSAVAAARAVEAGHEVVGVHLALSAKPGTLRTGARGCCTIEDSHDARRAADILGIPFYVWDFAERFTEEVIETFVGEYAAGRTPNPCLTCNEKIKFEALLEKAMALGFDAVCTGHYARLTVEDGVPVLRRSRDEGKDQSYVLASLTAEQLGHSMFPLGDSLKSQVRQEAAERGLAVAKKPDSHDICFIPDGDTKKFLESKLGQKPGQLVDAETGAVLGEHTGVHGFTVGQRKGLGIDAPAPDGRPRYVLSLEPVSGTVKVGSADHLGVTEIDAKRPIWPSQRELDGPTECVVQVRAHGGTADAVAEVADGGMSIRLRRPLRGVAPGQAVVLYRPEEEGDLVLGSALIAATR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_STAAS
Sequence: MKLNTLQLENYRNYDEVTLKCHPDVNILIGENAQGKTNLLESIYTLALAKSHRTSNDKELIRFNADYAKIEGELSYRHGTMPLTMFITKKGKQVKVNHLEQSRLTQYIGHLNVVLFAPEDLNIVKGSPQIRRRFIDMELGQISAVYLNDLAQYQRILKQKNNYLKQLQLGQKKDLTMLEVLNQQFAEYAMKVTDKRAHFIQELESLAKPIHAGITNDKEALSLNYLPSLKFDYAQNEAARLEEIMSILSDNMQREKERGISLFGPHRDDISFDVNGMDAQTYGSQGQQRTTALSIKLAEIELMNIEVGEYPILLLDDVLSELDDSRQTHLLSTIQHKVQTFVTTTSVDGIDHEIMNNAKLYRINQGEIIK
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WNK1_ORYSI
Sequence: MMGPKANAAAAGDLPEYAEVDPTGRYGRYNDVLGKGASKTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDYSLMNYLRQPYLEHAYSNVSMMSNGLSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDGHVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVPDWRPGPGIEESQDTTYCHNCGSNVSSCGSLYAYMSSAARGCQCAELHGRFEEITFQANGEQTDLQDSGGSSDDGGGQTQHVKDQEAVHSNGFVQMGRRGPPDQFCFSSFQEQSCSPRHYEYDTSLQAKGFDMKHEVKMAKYKARKMAHLRRAIHPSLDFDNLNGERRMKSSLNKLQSFHIGKNHNFRIPTCERSPGARDAEEDPDIFNLAYHSRHPDPGAQRARHCEVDAQSSPDLMFTARSYYTGAQLPTNLPRTKSVTLNAVDA
What are the official names of this protein?
Probable serine/threonine-protein kinase WNK1, OsWNK1, Mitogen-activated protein kinase kinase 1, Protein kinase with no lysine 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Protein: NFUA_SHESR
Sequence: MITISDAAQAHFVKLLADQPEGTHIRVFVISPGTAQAECGVSYCPPDAVESDDIELEFNGFSAMVDEKSAPFLEEASIDFVTDQLGSQLTLKAPNAKMRKVSSDAPLAERVEYVIQSEINPQLASHGGNIMLVEITQEGVAVLQFGGGCNGCSQVDITLKDGIEKQLLDMFPGELTGVRDVTDHQHGEHSYA
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: FABA_ECO27
Sequence: MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTANDLKVGLFQDTSAF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHS_BURVG
Sequence: MIHKLTSEERKTRLEGLPHWTAVPGRDAIQRSLRFADFNEAFGFMTRVAIKAQEMNHHPEWFNVYNRVDVTLSTHDADGLTERDIELAQFIDRVCAHTLPAA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: ACM5_RAT
Sequence: MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
What is the function of this protein?
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.  Primary transducing effect is Pi turnover.
What are the official names of this protein?
Muscarinic acetylcholine receptor M5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: RNFA_HAHCH
Sequence: MTEYLLILVSTILVNNFVLVQFLGLCPFMGVSNKLETAMGMSLATTFVLTLSSLCSYLAYEYLLAPLGMEFLKTITFILVIAVVVQFTEMVIKKTSPLLYRVLGIFLPLITTNCAVLGVALLNIKKQNDFMESILYGFGAAVGFSLVLTLFSAMRERIAAADVPEPFKGGAIGMITAGLMSLAFLGFTGLVNI
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROK_BORBR
Sequence: MNASANLCAASDNDPQPGDQEAAHPVACAGDEPAAFLPHDLPIFLVGMMGAGKTTIGRGLARALRREFIDLDHELEARCGVRVPVIFEIEGEAGFRRREAAALQECTQRRQIILATGGGAVLAAENRQALRERGIVIYLRASVEELFRRTSRDRNRPLLATADPRATLRELMVAREPLYNEVADLVIDTGSMPIATLVKSLLPKLQAYEKK
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEE_PROMT
Sequence: MNYKLKTRSEWLDEYHQGVRYGLQGKLILEESSPFQKITIYESKRYGKALLLDDCWMTAEKSEKCYHECLIHPALCCSTQIENILIIGGGDGGSARECLKYKEVKSIDLVEIDLRVIELSQKYLPTIGGDAWSDSRLNLQIKNGIDWVKHTQENSYDVIIIDGADPIGPSKELFSNSFLKDCKRILKQGGVLATQSESPESFQKIHINIVKVLREIFDYADPMYGSVSIYPSGLWSWTFASMKQQRYMHPKKSRVKEISENCQIWSTRWQQGAFNSIPAFIERELAKK
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_ECO27
Sequence: MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQSYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQMELVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEVPVEYIAGKVVAKDYIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETLRVDPTNDRLSALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLREEIEGSGILSKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVTDEIHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQVDYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKRGGVVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPCVSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLKLGDLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEIRSLGINIELEDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: GRPE_RICAE
Sequence: MIDDNIENNEQTINDIAEEIVETANPEVTALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKPANSDVEVTNIIAGVQMTKDELDKVFHKHHIEEIKPEIGSMFDYNLHNAIAQIEHPDHAPNSIITLMQSGYKIRDRLLRPATVQVVKKP
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARD_PECCC
Sequence: MPNDLYAIYNRYTSRTLFFKYCATATLTHRLTRRLSLFTLKKCLARPQGRLFSLVNSIYFGGETLEEVQSTATFLARSGIACVLDYAVEGENDETQFDKAMENTLRLIEMSQQTDSLPFVVIKPSSLGSVAVYARQSERLALDEASASAWSRIVTRFSRLFDYARSHGVHVMVDAEQTAIQPAVDRLVLDMMREFNRDSAVITLTLQFYLKDQLRFLDECYQRACQDNFLFGVKVVRGAYLEEEKRVNGGVRCFATKQETDRSYNAAVDYIALRLDRIAPFFATHNEESLALIMSSESLRAGRTWVGQLYGLGDHITYSLLQTGFRVCKYLPYGPLDKSLPYLLRRIEENAVASATFKKENKLLQKELLRRLVGGM
What are the official names of this protein?
Carbapenem antibiotics biosynthesis protein CarD.
What is the protein family that this protein belongs to?
Belongs to the proline oxidase family.
Protein: MSCL_LISMH
Sequence: MKKMLVEFRDFALKGNVLDLAVAVVIGAAFGKIVSSLVDNIIMPLVGVLLGGLDFTDLSFKVGKSVIQYGAFIQSIVDFIIIAFAIFIFVKVLTSFIKKKEQTVEETPVPPTEEYLKEIRDLLKEQQK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FEN_METST
Sequence: MGVKFKDITNPEPIEMKELEGKILTVDASNVIYKFLSSMRQTDGTPLRDLNGHITSHLNGIMFQTSTLIEKDIKPVYVFDGKAPDLKKETQEERINIKKESEKKYLEAKEVGDVVAARKYAARTTHLNKEIIKSSKKLLDLMGIPYVQARTEGEAQASYMVSQNDAWAVVSQDYDCLQFGATRMIRNLKLSKSNSKNLELISLEKTLKELNLTREQLVDVAMLVGTDFNKGVYGIGAKKGIKLIHKYGTLEKALESLNETMEVDAELIREIFLNPNVVHNYTIEFKRPKKSQLLDFLCGEHDFDERRTISAIKKLQAKTAQSSLEDWF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: FABG_STAAN
Sequence: MKMTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQKATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNAVAPGFIVSDMTDALSDELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVNGGMYM
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
What are the official names of this protein?
3-oxoacyl-[acyl-carrier-protein] reductase FabG, 3-ketoacyl-acyl carrier protein reductase, Beta-Ketoacyl-acyl carrier protein reductase, Beta-ketoacyl-ACP reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: TRMB_CAMJE
Sequence: MPNFKSKKIKEINLPYSKDDVEFLWLAKNDNVSLIYTKVQEESFFLQIKKAQNGFVIKGDKHTKPSKIGYLQKALKIFKEGFCEDIINEAFGLKNNALIEKTPFIVDNFDELLSRLQGKIYIEIGFGSGRHLLYQAKENPNVLILGVEIYNPALTQVAKLAKAQNVNNILLIQSDARLLLSVLKSKSVEKIFLHFPVPWDKKPHRRVIGKDFCKECARVLVQNGRFELRTDSFEYFNFTLEQFLTFPAPKFSLRKNENLEISSKYEDRWKKQEKNIYDLWVWNFNQECKNYELNEFNLSSVEFSKEDLKKIEQNFKNITIKKDDFFLHFESIYKQDENLLLKVAFGAFNKPEHCYLHLDKTIDFAFKEPFKIQENIKAINELKEILKVQFKI
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: SULA_PECCP
Sequence: MRTQSISSHNVQSSSFSANQHAAETSISAGGIISEIVYNADQPIVTHLLLPLLQQLGTQSRWLLWLSPQQKLSRPWVQQSGLPLDKMVQLHHINPLFTVDAMERALLTGNYSAVLCWLPHELTEEEKVRLRHAAQAGNTYGFIMRPESTGGDAYRLFPSLKIHSTLYH
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: GCH4_PELPD
Sequence: MPDMQKRPDHRRIPISKVGVKDISYPIVVMDKNRSLQHTVARVNMYVDLPHQFKGTHMSRFVEILNRHREQIALDKLETILEEMKARLGSASAHLEIQFPYFIDKRAPVSGARSLMEYSCEFSASLTDTLDFVLGVRVPLTSLCPCSRELAIHGAHNQRSIMTVRVRYRDFIWIEDLVELIEQCGSSPLYSLLKRVDEKYVTEQAYENPRFVEDMVREAYSRLAGMENITWFSVETENFESIHNHSAYAAVELDRRG
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.