PharMolix/UniProtQA huggingface dataset:
Protein: MCU_CAEEL
Sequence: MRNGRCLVTPFVTAQRLANLRNTLWNRQQIAFSTTTASSSTSPIQESSSPLSIRFEYGLPLLDVPLPSRNEPCQFTMRPLSDTIGSLCEFLRQEDRGIDYVAVYGTNGVKLATCTSIEHLLQFGSFRLRLNDKFFDVTVPKTGTMPYDSDKLRQLDDLRATVASLHAALCVDEYKLSREKKLLLQLENAETLLAPLHDAKRKIEQECEAHTDRVMWAGFAAMGVQTGLFARLTWWEYSWDIMEPVTYFATYSTVCATFGYYLYTQQSFEYPSARERVYTKQFYRRAQKQNFDIEKYNRLVTEVDELRNQLKRMRDPLFQHLPVSYLSNLEAEK
What is the function of this protein?
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:25313960, PubMed:31983639).  Constitutes a pore-forming and calcium-conducting subunit (By similarity).  Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity).  Required for rapid mitochondrial calcium uptake and mitochondrial reactive oxygen species (mtROS) production after wounding (PubMed:25313960).  In addition, together with mitochondrial calcium regulator micu-1, required for mitochondrial calcium uptake following axon injury in PLM touch receptor neurons (PubMed:31983639).
What are the official names of this protein?
Calcium uniporter protein, mitochondrial, cMCU.
What is the protein family that this protein belongs to?
Belongs to the MCU (TC 1.A.77) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LTRB_LACLM
Sequence: MVYTKHIIVHKLKHLRQAKDYVENAEKTLVNESNEDHLTNLFPYISNPDKTMSKQLVSGHGITNVYDAANEFIATKKLKALSKGTDFNFDPQTGKVRFNVESLEKNNAVLGHHLIQSFSPDDNLTPEQIHEIGRQTILEFTGGEYEFVIATHVDREHIHNHIIFNSTNLYTGKQFDWKVIPKEKTKSGKAYDVTKNNFEKVSDKIASRYGAKIIEKSPGNSHLKYTKWQTQSIYKSQIKQRLDYLLEMSSDIEDFKRKATALNLSFDFSGKWTTYRLLDEPQMKNTRGRNLDKNRPEKYNLESIIERLETNELSLTVDEVVERYEEKVDVVKQDFDYQVTVEKGQIDHMTSKGFYLNVDFGIADRGQIFIGGYKVDQLENRDCVLYLKKNETFRLLSEKEASFTKYLTGHDLAKQLGLYNGTVPLKKEPVISTINQLVDAINFLAEHGVTEGTQFNNMESQLMSALGEAEEKLYVIDNKIMELTKIAKLLIEKESDHSQAVINELENLGVGPSIKYQDIHQELQSEKMSRKILKNKFEQTVDEINTFNEIRVTTLEENKGKIL
What is the function of this protein?
Mediates initiation of conjugal transfer possibly by introducing a single-stranded nick at the potential origin of transfer.
What are the official names of this protein?
Group II intron-interrupted relaxase LtrB, Conjugative nickase, Mobilization protein MobA.
What is the protein family that this protein belongs to?
Belongs to the mobilization (MOB) protein type 1 family.
Protein: KTHY_WOLSU
Sequence: MYVAIEGVDTCGKSTQIALLKRRFPGAIFTKEPGGTALGMKLRELLLGGEAKSAKAELLLFLADRAEHMELVIKPALDKLLFSDRSLISGMAYAKGWDELWLKSLNLFATEGIVPDKVVILELTAKELSYRLSQKSHDSIESRGVEYLLELQERIKQMTALLGIPSLTLSASLSPEEIHGRIVSGFVLKG
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: SYE_KLEP7
Sequence: MKIKTRFAPSPTGYLHVGGARTALYSWLFARNHGGEFVLRIEDTDLERSTPEAIEAIMDGMNWLNLQWDEGPYFQTKRFDRYNNVIDEMLEAGTAYKCYCSKERLEALREEQMAKGEKPRYDGRCRHSHEHHADDEPCVVRFANPQQGSVIFDDQIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVVDDWDMAITHVIRGEDHINNTPRQINILKALNAPVPVYAHVSMINGDDGKKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSHGDQEIFTREEMIEFFSLGAVSKSASAFNTDKLLWLNHHYINTLPAEYVATHLQWHIEQENIDTRNGPQLAELVKLLGERCKTLKEMAQSCRYFYEEFAEFDADAAKKHLRPVARQPLEMVRDKLAAISDWTAENVHHAIQATADELEVGMGKVGMPLRVAVTGAGQSPALDVTVHAIGKSRSVDRINKALAFIAEREGQAS
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T2R13_PANTR
Sequence: MESALPSIFTLVIIAEFIIGNLSNGFIVLINCIDWVSKRELSSVDKLLIILAISRIGLIWEILVSWFLALHSLAIFVSGTGLRIMIFSWIVSNHFNLWLATILSIFYLLKIASFSSPAFLYLKRRVNKVILMILLGTLVFLFLNLIQINMLIKDWLDRYERNTTWNFSMSDFETFSVSVRFTMTMFSLTPFTVAFISFLLLVFSLQKHLQKMQLNYKGHRDPRTKVHTNALKIVISFLLLYASFFLSILISWISELYQNTVIYMLCETIGAFYPSSHSFLLILGNAKLRQAFLLVAAKVWAKR
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 13, T2R13.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CHEB1_METMA
Sequence: MNEFGDSMIRTLIVDDSAFMRMAIRSMLASSPDIKIAGDACNGKEAVDKSKSLHPDIIIMDVNMPVMDGLTAVKTIMSTDPVPIIMFSTLTVEGSKEALEALQLGAIDFVPKSESHHDVNKIEKELVDKIRNIHSSNPSILRLINMRKFKGEVVRGKWSCAGDFAVLIGSSTGGPSSLEQVIPRLPGDLPAPVFVVQHMPEGNFCKQLAERLNFLSELEIKEARNNEKVTAGVVYIAPGGYHMTVKKALGVTRIKLIKSQPVHAVMPAVDVIAESMLDVYGKNIVAAILTGMGFDGAAGFKKIRDAGGSTIACSEDTCVIFGMPKAAIAAGGIDTVKPIFEIPEEIVRMSEVKCNGK
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 1.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1461_PROM3
Sequence: MGLAGFARPLQWFKSQWLWLLLSIAAFWLLMRVQVEWLWFGQFDWQGMLLRRWLWQLGGLLLALLVVATCQLWQRNWIKLEGASNLAEPALPLHGWRYGLGLLGCFVVVVGDLVLLTRLAWLACFKPFALGHWWSEPFEDIWALVIPLSCVFISICVMLGNARGGRIAHLMGCFCFSISIARGWGLWSLALAIPPTGIKEPLLGADVSFGLGQFPALAFALVVLLAQLVLTTSTTIWMKLAQPESLSDWVFKGLSPRQCDVMRPLIGIILLTLSALLWLSRHELLWTQNGTVAGAGWLDAHLILPLRSLASLAILVLAFLVIPFPWIQQRRLWRLIASIIGVGAILLEVLLAPFVQWMVVKPRELKLETPYIIRAIKATRKAFQLDSITTTLINPQPQLTQLDLEQGASTLRNIRLWDSQPLLATNRQLQQLRVYYRFSNAAVDRYRFVPDKANRQQVMITARELDQAALPKRSRTWLNRHFVFTHGYGFTLSPVNTRAPDGLPDYFISDLGTSTRLEGSSELGITREDVKEAVPIGRAALYFGMLPSPYALAPSKLKELDYPVGDKNIYNHYLGSGGVPVGHPWQQLAAAMYLFEPRLLNTGSLTINSKLLIRREVRQRVSAIAPFLEVIGDPYLVSTSVNSRDHDYQAKQNQYWIVEAYTSSRTYPYAANLPDGRPVRYLRNSVKAIVDAYSGRVHLYVSEPRDPIILGWQRLFPDLFKPLEEMPSSLREHLKVPTDLFNVQVQQLLRYHVTDPRIFYSGDDVWQVPKELYGKRQVPVDPYHITAQLGSQESSEFLLLQPLTPLARPNLSAWLAARSDGDHYGKLVLLRFPSQTPIFGPEQIQALINQDPQISQQFGLWDRAGSEVVQGNLLVVPLGKALLYVEPVYLRARQGGLPTLTRVVVSDGKRIAMAEDLGEGLRALVDGSSKKAVYLNRNDLPPIKAADQSN
What are the official names of this protein?
UPF0182 protein P9303_14611.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL6_PSEFS
Sequence: MSRVAKNPVKLPAGVEVKFAGQQLSVKGAKGTLELNIHSSVEIVEEAGELRFAARNGDQQTRAMAGTTRALVNNMVQGVSQGFERKLQLVGVGYKAQAKGTVLNLALGFSHPVDYELPEGITAETPSQTDILIKGIDKQLVGQVAAEIRDFRPPEPYKGKGVRYADEVVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ADRB3_HUMAN
Sequence: MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  Beta-3 is involved in the regulation of lipolysis and thermogenesis.
What are the official names of this protein?
Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS21_BACHK
Sequence: MSKTVVRKNESLEDALRRFKRSVSKTGTLAEARKREFYEKPSVKRKKKSEAARKRKF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: MUTS_STAAC
Sequence: MSNVTPMMQQYLKIKSEYQDCLLFFRLGDFYEMFYEDAKEASRVLEITLTKRDAKKENPIPMCGVPYHSADSYIDTLVNNGYKVAICEQMEDPKQTKGMVRREVVRIVTPGTVMEQGGVDDKQNNYILSFVMNQPEIALSYCDVSTGELKVTHFNDEATLLNEITTINPNEVVINDNISDNLKRQINMVTETITVRETLSSEIYSVNQTEHKLMYQATQLLLDYIHHTQKRDLSHIEDVVQYAAIDYMKMDFYAKRNLELTESIRLKSKKGTLLWLMDETKTPMGARRLKQWIDRPLISKEQIEARLDIVDEFSAHFIERDTLRTYLNQVYDIERLVGRVSYGNVNARDLIQLKHSISEIPNIKALLNSMNQNTLVQVNQLEPLDDLLDILEQSLVEEPPISVKDGGLFKVGFNTQLDEYLEASKNGKTWLAELQAKERQRTGIKSLKISFNKVFGYFIEITRANLQNFEPSEFGYMRKQTLSNAERFITDELKEKEDIILGAEDKAIELEYQLFVQLREEVKKYTERLQQQAKIISELDCLQSFAEIAQKYNYTRPSFSENKTLELVESRHPVVERVMDYNDYVPNNCRLDNETFIYLITGPNMSGKSTYMRQVAIISIMAQMGAYVPCKEAVLPIFDQIFTRIGAADDLVSGKSTFMVEMLEAQKALTYATEDSLIIFDEIGRGTSTYDGLALAQAMIEYVAETSHAKTLFSTHYHELTTLDQALPSLKNVHVAANEYKGELIFLHKVKDGAVDDSYGIQVAKLADLPEKVISRAQVILSEFEASAGKKSSISNLKMVENEPEINQENLNLSVEETTDTLSQKDFEQASFDLFENDQESEIELQIKNLNLSNMTPIEALVKLSELQNQLK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RS3_LATSS
Sequence: MGQKINPTGFRVGVIRDWDAKWYAEKDFATFLHEDLKIRKYINTKLADASVSTIEIERAANRVNVSIHTAKPGMVIGKGGSEVENLRKALNNLTGKKVHINIVEIKKPDLDAHLVGEGIARQLEARVAFRRAQRQAMQRTMRAGAKGIKTQVAGRLNGADMSRIETHAQGTVPLHTLRADIDYSWDEAMTTYGKLGVKTWIYRGEVLPAKANNNTKGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: GET3_CANDC
Sequence: MDFDLEPSLEELIKQDTLKWIFVGGKGGVGKTTTSSSIAVQLALQHPNDEFLLISTDPAHNLSDAFCQKFGKDARKVEGLSNLSCMEIDPEAAMSDLQQQAQQYNNDPNDPLKSIMNDMTGSIPGIDEALSFMEVLKHIKNQKVNESDDSTDKISYRTIIFDTAPTGHTLRFLQLPSTLQKLLGKFQQLSGKLGPMMSMLGGGGQGQQDMFAKLNEVQKNVEEVNEQFTNPDLTTFVCVCISEFLSLYETERMIQELMSYQMDVNSIVVNQLLFADDDENPCKRCVARWKMQKKYLDQMAELYEDYHLVKMPLLGSEIRGVENLKRFSKFLIKPYDPKVDRAIITEMKEQ
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting.  Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.  Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Golgi apparatus. Note=GET1 and GET2 are required for targeting GET3 to the endoplasmic reticulum.
Protein: ARFB_MYCBO
Sequence: MDFVIQWSCYLLAFLGGSAVAWVVVTLSIKRASRDEGAAEAPSAAETGAQ
What is the function of this protein?
Required for wild-type expression of ArfA and ammonia secretion.
What are the official names of this protein?
Uncharacterized membrane protein ArfB.
What is the protein family that this protein belongs to?
Belongs to the ArfB membrane protein family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: THIM_SYNFM
Sequence: MLAETARCLEKIRAQRPLVHNITNYVVMNYTANALLCLGASPVMAHAVEEVEAMVELADALVINIGTLSAPWVDAMFLASRAAIERSIPVVLDPVGAGATAFRTDTARRLLDEFGITVLRGNASEIMALAGLNSTTRGVDSVHATDEARSAAVELANVYKAVVAITGAEDFITNGPKSARVANGHPLMGRVSGTGCVASSIVAAFCAVHPDPLVAATAGLSVLGIAGELAARDNPGPGTFHHLLLDALDAMETRNIEEKGRIAVSWEQ
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: Y1639_ARATH
Sequence: MYKLPQRNCADKQEYTVHMRKMGMVIFACLLLLIIFPTFGYADINTSSPLSIGQTLSSPDGVYELGFFSPNNSRKQYVGIWFKNIAPQVVVWVANRDKPVTKTAANLTISSNGSLILLDGTQDVIWSTGEAFTSNKCHAELLDTGNLVVIDDVSGKTLWKSFENLGNTMLPQSSVMYDIPRGKNRVLTSWRSNSDPSPGEFTLEFTPQVPPQGLIRRGSSPYWRSGPWAKTRFSGIPGIDASYVSPFTVLQDVAKGTASFSYSMLRNYKLSYVTLTSEGKMKILWNDGKSWKLHFEAPTSSCDLYRACGPFGLCVRSRNPKCICLKGFVPKSDDEWKKGNWTSGCVRRTQLSCHTNSSTKTQGKETDSFYHMTRVKTPDLYQLAGFLNAEQCYQDCLGNCSCTAFAYISGIGCLVWNRELVDTVQFLSDGESLSLRLASSELAGSNRTKIILGTTVSLSIFVILVFAAYKSWRYRTKQNEPNPMFIHSSQDAWAKDMEPQDVSGVNLFDMHTIRTATNNFSSSNKLGQGGFGPVYKGKLVDGKEIAVKRLSSSSGQGTDEFMNEIRLISKLQHKNLVRLLGCCIKGEEKLLIYEYLVNKSLDVFLFDSTLKFEIDWQKRFNIIQGVARGLLYLHRDSRLRVIHRDLKVSNILLDEKMIPKISDFGLARMSQGTQYQDNTRRVVGTLGYMAPEYAWTGVFSEKSDIYSFGVLLLEIIIGEKISRFSEEGKTLLAYAWESWCETKGVDLLDQALADSSHPAEVGRCVQIGLLCVQHQPADRPNTLELMSMLTTISELPSPKQPTFTVHSRDDDSTSNDLITVNEITQSVIQGR
What are the official names of this protein?
G-type lectin S-receptor-like serine/threonine-protein kinase At1g61390.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ISPE_LAWIP
Sequence: MIYSHLSSTSCTITTGCKVNLNLYITGILPNGWHKIDSIFLPLSEPHDELHIEITNHNQGLHLSCNILDIELENNILTKTYTLFTKATHFTPSISIYLKKGIPYGAGLGGGSSDAAALLTWLQKNSPLPLSPSKLLKLAAEIGADVPFFLKNKPCRATGIGEKLEEISLSNLNISGNTLFIICPNLKISTPYAYKMWDDYNKKQIATSSRYNNNLTKKYSWDRSSPSTHLSDYLWMKNDFEPVIFSEYTELSVFKEQLLQFGARAAVLSGSGSSIYGLFKEYNQTSIMTEFYKKKNILTFSQLLQ
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: MEMO1_CAEEL
Sequence: MSTWRASLGNTILVFCLKVFQNSRALFLRTFGLPFARYLNFILPSEFKMSLNGFGEHTRSASHAGSWYNANQRDLDRQLTKWLDNAGPRIGTARALISPHAGYSYCGETAAYAFKQVVSSAVERVFILGPSHVVALNGCAITTCSKYRTPLGDLIVDHKINEELRATRHFDLMDRRDEESEHSIEMQLPFIAKVMGSKRYTIVPVLVGSLPGSRQQTYGNIFAHYMEDPRNLFVISSDFCHWGERFSFSPYDRHSSIPIYEQITNMDKQGMSAIETLNPAAFNDYLKKTQNTICGRNPILIMLQAAEHFRISNNHTHEFRFLHYTQSNKVRSSVDSSVSYASGVLFVHPN
What is the function of this protein?
Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3 (PubMed:28085666).  In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production (PubMed:28085666).  May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity).
What are the official names of this protein?
Protein memo-1 homolog, Mediator of ErbB2-driven cell motility 1 homolog, Mediator of cell motility 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the MEMO1 family.
Protein: NNRD_BATDJ
Sequence: MAAREVFKRVIPPLSTRLHKGQSGRIGVVGGSLEYTGAPYYAAMAALYTGVDLCHVFCAQDAAPAIKCYSPELVVHPSIVSKRDCEHLNPVAIDNCIETAVDRMSPLLCRLDSLVVGPGLSRDPVMLAMAKRIVEKVISLGTPLVIDADGLCLVEQTPGLVMGYQNVILTPNTNEFKRLCHSVNIDASENCEVAAVQLSKALGSVTILCKGSKDLIATGDDILFVSDPTSLRRCGGQGDVLAGILCAFLAWRNGYQSGRWTAQDQSTDISLMIVASNASSFARKCAALAFEKHKRSIVASSILKEIGPAFDSLYDDEL
What is the function of this protein?
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP.  Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
What are the official names of this protein?
ATP-dependent (S)-NAD(P)H-hydrate dehydratase, ATP-dependent NAD(P)HX dehydratase.
What is the protein family that this protein belongs to?
Belongs to the NnrD/CARKD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR6_RAT
Sequence: MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSNSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFGLNNHLVWAKLRASKLNTWISLKQADKKIRECNL
What is the function of this protein?
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.
What are the official names of this protein?
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, PAICS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
Protein: ACSA_RHILW
Sequence: MSEKIYPVTKPVKARALIDKEKYLKWYEESVENPDKFWGKHGKRIDWFKPYTKVKNTSFTGKVSIKWFEDGQTNVSYNCIDRHLKTNGDQVAIIWEGDNPYIDKKVTYNELYEHVCRMANVLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVVFGGFSPEALAGRIVDCESTFVITCDEGLRGGKPVPLKDNTDTAIHIAARQHVHVSKVLVVRRTGGKTGWAPGRDLWHHQEIATVKPECPPVKMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTHEYVFDYHDGDVYWCTADVGWVTGHSYIVYGPLANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTAIRSLMGAGDDFVTRSSRSSLRLLGTVGEPINPEAWEWYYNVVGDKRCPVIDTWWQTETGGHMITPLPGAIDLKPGSATVPFFGIKPELVDNEGKVLEGAADGNLCITDSWPGQMRTVYGDHDRFIQTYFSTYKGKYFTGDGCRRDADGYYWITGRVDDVLNVSGHRLGTAEVESALVSHNLVSEAAVVGYPHPIKGQGIYCYVTLMAGHEGTDTLRQDLVKHVRAEIGPIAAPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVDDLIANRQNKATA
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: UVRC_CORA7
Sequence: MADPSKYRPAPGSIPTDPGVYKFRDENRRVIYVGKAKNLRARLSNYFQDITQLHPRTRQMVLTAASVEWTVVASEVEALQLEYTWIKRFDPRFNVMYRDDKTYPMLAVSVGESIPRAFFYRGPRRKGVRYFGPYSHAWAVRESLDLLTRIFPMRTCAKGVFNRHERLGRPCLLGYIGKCDAPCIGRVSPEEHRETVNQLISFMNGNTAPVRKRVTQRMEEAAENLEFELAARLRDDLGAIDKLMEQQAVVLPDGTDADLIAFSSDELEAAVQIFHVRTGRIRGQRGWVVERSGDQATTDVVEEGQADPGLPALIQNFLIQFYSDAVERQRQEAAEDAKLERRGVDQESHAEPRQGNAIPREILVQALPEEAEEVKIVLEELRGAQIDVRVPQRGDKRALLETVERNAKEQLKQHKLKRVGDLTARSAALQELQEALGMDSAPLRIECTDISHIQGTDVVASLVVFEDGLPRKSDYRRYRIKEAAGDGRSNDVGSIAEVTRRRFKHHHDDKRAVPDEELENTTFAEEMVREEAASQTKRSSYPPQLFIVDGGAPQVAAAQAVFDELGIVDVTLIGLAKRLEEVWVPGDDEPVILPRNSQALFLLQHLRDEAHRVAISYHRQQRSKRMRSSVLDAVPGLGPQRRTDLVKHFGSVKKLKEASVEEIAEVKGFGPKLAQTVFDHLHAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14Z_TREPA
Sequence: MATVAMINKAKATPKYATRRYNRCGVCGRPRGYMRRFQLCRLCFRKLASEGQIPGVTKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: AROE_ACIBT
Sequence: MTKQFAVIGNPIEQSRSPELHHAFAEKTGVDLNYQKRLAPLDGFESSMRSFFAEGGSGMNVTVPFKEQAFALCDVLTERAQIAKAVNTLWMENGKLHGDNTDGQGLVAAIQALEWNLENTTILILGAGGATRGVIYPLVQAGTQKIVIANRTLARAEQLVDDLKTAVPQAQLQAISLNDLEGDFDIVINATSASLSGDALQLPEKLQFKYAYEMAYGKPSSFLDQAKQRNVPYSEGFGMLVGQAIEAFYIWNGVRPQLKDFL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: 1433B_TOBAC
Sequence: MAREENVYMAKLAEQAERYEEMVSFMEKVSTSLGTSEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNEDHVKCIQEYRSKIESELSNICDGILKLLDSCLIPSASAGDSKVFYLKMKGDYHRYLAEFKTGAERKEAAESTLSAYKAAQDIANAELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQDDGADEIKETKTDNEQQ
What are the official names of this protein?
14-3-3-like protein B.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: PRMA_CUPPJ
Sequence: MAFQECVIEVAQDQAEAWSDALFDLCALSVSVEDADADTPDEQPLFGEPGLEPTKLAWNRSRVVALFGDDTDPALAVAAASNALGIDPVPAYALREVEDQDWVRLTQSQFEPIRIGERIWVVPSWHDAPEPDAVVLELDPGLAFGTGSHPTTRLCMQWLEQNLKAGETVLDYGCGSGILAIVAKKLGAGDTLGIDIDPNAVEASRYNAERNQVQADFALPESVSEATYDLVVANILSNPLKLMAAMLSARVRAGGRLILSGVLERQAEEVAAAYAPWLPLTVWRSEEGWVCLHGTRP
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.