PharMolix/UniProtQA huggingface dataset:
Protein: PHB2_PONAB
Sequence: MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYPTADNLVLNLQDESFTRGSDSLIKGKK
What is the function of this protein?
In the plasma membrane, is involved in IGFBP6-induced cell migration (By similarity).  Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates.  Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
What are the official names of this protein?
Prohibitin-2.
What is the protein family that this protein belongs to?
Belongs to the prohibitin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Cytoplasm. Nucleus. Cell membrane.
Protein: POLC2_TOBAC
Sequence: MAEADDPQDIADRERIFKRFDANGDGQISATELGETLQTLGSVTPEEVKYMMDEIDTNKDGFISFQEFIEFARANRGLIRDVAKIF
What are the official names of this protein?
Polcalcin Nic t 2, Calcium-binding pollen allergen Nic t 2.
Protein: PGK_SINFN
Sequence: MTFKTLDDLTDIAGKRVLVRVDLNVPVKDGQVTDTTRIERVAPTIRELSEKGAKIILLAHFGRPKGEPVADMSLKAIAPAVEEILDQRVHFAADCIGDKAANAIAEMNDGDVLLLENTRFHKGEEKNDPAFVTALAANGDLYVNDAFSAAHRAHASTEGLAQHLPAYAGRTMQAELEALEKGLGNPKRPVVAIVGGAKVSTKIDLLQNLVKKVDALVIGGGMANTFLAAQGVDVGKSLCEHDLAETAKSIIAAAAAAGCAIVLPEDGVVAREFKAGADNAVVDIKAIPADAMVLDVGPKSVAAINDWISRAETLVWNGPLGAFEIAPFDKATVAAAKHAAARTRQGSLVSVAGGGDTVAALNHAEVADDFTYVSTAGGAFLEWMEGKPLPGVDILHKQK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCNL5_MOUSE
Sequence: MPVKKKRKAPGVAAAVAEDAGLKKCKIPSYCRSQPPARLISGEEDFSRKKCLAWFYEYAGPDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEKLQSRFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKIRQTS
What is the function of this protein?
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs).  May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth.
What are the official names of this protein?
DCN1-like protein 5, DCNL5, DCUN1 domain-containing protein 5, Defective in cullin neddylation protein 1-like protein 5, Squamous cell carcinoma-related oncogene 5.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Subcellular localization is independent of the interaction with cullins.
Protein: SLX1_DEBHA
Sequence: MDDNEEYDTKRKTRCGLHVHPDFYGVYLLRSVPKPKSFYIGSTPNPQRRLRQHNGELKNGGAYRTKKSGFRPWEMICLVYNFPSKNVALQFEHALQHPYQTRHIKSELRITHKRNSGNTLHHKLGNIRLLLGSSFFSRMGLKVLLFDPEVHSAWCINKFGVNVTDNVQVNVTRFEDYFSRDNNDESSGFSLSRQKESERIYFESSKKILFFDNQPCFICNETIDYQSESEVSFSSKLDVDAYLREGNMPLLAICYHENCRKLYHLSCLGLHFLEKGDELSNKTDSEEKLGDTVNYLTPLQGKCLSCNNFINWAKLSKMSTKLREYFLKDLLNTGATSQFIENDADD
What is the function of this protein?
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: M2DH_ASPTN
Sequence: MAPLKLNSRNLAQIFAAGKDRVKVPTYQRGSAVKEGIVHVGVGGFHRAHLAVYVDQLMQNHGVNDYAICGVGLQPFDAAMRDALRSQDHLYTVIERSAKGSFAHVVGSINSYLFAPDNREAVIAKMAHPDTHIVSLTITESGYYYNENTHELQAEHPDIQFDLDPANEKTPRTTFGFLYAALARRHQQGLRPFTVLSCDNMQKNGSITRHMLESFARLRNPELAKWIAEQGAFPNAMVDRITPQTSPTDKKALAETIGIEDSWPVVTEPFMQWVLEDQFSDGRPPFEKAGAQVVKNVHDVEQFEKHKLRLLNGSHSAIGYAGQMAGFEYVHEVMEHPLYNRFVWQMMQEEVKPLLPEIPGVDIDEYCKTLMERFSNPTIMDQLPRICLNASGKIPQFIMPSIAEAIWVTGPFRRLCFVAAAWFRYLNGIDDSGKTFNVDDPMREELQAKARAGGTNPAELLNVKSLFGDDLRSDKRFLQEITTAMEAIARDGIMKTMPKYVD
What is the function of this protein?
Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.
What are the official names of this protein?
Mannitol 2-dehydrogenase, M2DH, MDH.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: CHEB4_ANADE
Sequence: MDAGPAPAREPRRIRVLVVDDSAVVRNVFQQELSADPGIEVVGTAPDPFAARDLILERAPDVITLDVEMPRMDGITFLHKIMRYRPTPVIVVSSLTPAGGALALEALAAGACDVMCKPGAAYSVGEMTADLVEKVKEAAAAGVRAPAPLPPPDRAATPRALARTTLQVVAIGASTGGTVAIERILAALPPGAPGIVVTQHMPELFTRYFANRLRDRSGLDAREAQGGESVVPGTVLVAPGSRHMLLRRSGARYVVEIKDGPRVNRHRPSVDVMFRSVARAAGPNAIGVILTGMGGDGAQGLRAMRDAGARTVAQDEASCVVYGMPKVAVELGAVERSLPLDRIAPEILRLAGEAGG
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 4.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GON3_ORYLA
Sequence: MDVSSKVVVQVLLLALVVQVTLCQHWSYGWLPGGKRSVGELEATIRMMGTGRVVSLPEDASAQTQERLRQYNLINDGSTYFDRKKRFMSQ
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Progonadoliberin-3, Progonadoliberin III, Salmon-type gonadotropin-releasing hormone, sGnRH.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: ERLN1_HUMAN
Sequence: MNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDIRTGRESSLPSKEALEPSGENVIQNKESTG
What is the function of this protein?
(Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production.
What are the official names of this protein?
Erlin-1, Endoplasmic reticulum lipid raft-associated protein 1, Protein KE04, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1, SPFH domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Protein: YIDD_HAEIG
Sequence: MAETHSLGTKILIKIIRLYQIMISPFIGARCRFVPTCSCYGIEALKTHGLLKGGWLTLKRVLKCHPLNAGGFDPVPPKTNNNDEKK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: AROB_CHLPN
Sequence: MMSETIITTPHVVKLISNFFQKKLFSSISTAYPLVIITDVSVQQHLLGPILDHIKMLGYQVIVLTFPPGEPNKTWETFISLQYQLVDQNISPKSSIIGIGGGTVLDMTGFLAATYCRGLPLYLIPTTITAMVDTSIGGKNGINLRGIKNRLGTFYLPKEVWMCPQFLSTLPREEWYHGIAEAIKHGFIADAYLWEFLNSHSKMLFSSSQILHEFIKRNCQIKAAIVAEDPYDRSLRKILNFGHSIAHAIETLAKGTVNHGQAVSVGMMIETRISLAEGVMKTPQLIDQLERLLKRFNLPSTLKDLQSIVPEHLHNSLYSPENIIYTLGYDKKNLSQHELKMIMIEHLGRAAPFNGTYCASPNMEILYDILWSECHVMRHC
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KU_FRACC
Sequence: MRATWKGVISFGLVSIPVRLYSATQERDVAFHQVRRSDGSRIRYRRVAEADGDEVNYADIAKGYELPDGETVVLTDEDFANLPLSTSRAIDVLEFVPLEQVDPIYFAKSYYVEPDRTGAKPYVLLRDALAASGRVALVKIALRQREQLATLRVRGGVFVLETMVWPDEVRQPDFPFLEEDVAVRPQELSVAASLIHTLAADFDPTRYTDNYREALQAVIDAKVAGREVVASPGGPASEAVGDLMAALRASIAAARAGRPGEAAVAGGAAVAGGAAVADGDAGPAAAGVTDEGPDDKASDDKASDDKASDGRRGGRTSSVKGASSAPGTRSTARKTPSSTRSTAKTNAATKTPPAKTSAAKASAAKTSAAKATSSRTAPKTAPRTPTSKTPPTRRSA
What is the function of this protein?
With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity.  Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA.  Recruits and stimulates the ligase activity of LigD.
What are the official names of this protein?
Non-homologous end joining protein Ku.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic Ku family.
Protein: TPIS_CALS4
Sequence: MRRPIIAGNWKMHKTPSEAVKLVEELIPLVKDAKAEVVVIPPFVDLTEVARVIKGTNILLGAQNMFWEEKGAYTGEISPVMLKEIGVTYVVIGHSERRQYFKETDEMVNKKVLSALSHDLKPIVCVGESLSQREEGKTYDVVLTQTREALKGVSEEDITKVVIAYEPVWAIGTGKNATPQDANEVIKAIRNTIAELYGKDKAEMVRIQYGGSVKPDNISGFMAESDIDGALVGGASLVAEDFAKIVNY
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_THEPX
Sequence: MDIEVKKKRFLKGVISVPGDKSISHRAVMIGSIAEGITEIENFLLGEDCISTINCMKNLGVDIELKGTNVKVQGKGLYLNKSEKILDVGNSGTTIRLLMGILAGQKFETTLTGDDSIKRRPMGRVITPLSMMGAKIEAREGNFAPLTVFGNKLKGIYYKMPIASAQVKSSIMLASLYADDKTTIEEPYPSRNHTELMFSSFGAKVEVNGTKITCYPGYKLQGQKVIVPGDISSAAYFIVAATLVPNSEVTIKNVNVNPTRTGIIDVIKEMGGDIVLTNERTINNEKVADITVKTSRLKGIEIGGSLIPRLIDEIPVIAVAAVFAEGKTVIKDAEELKVKESNRINTITSELKKMGAKIFETEDGMIIEGTGFLKGNTVESYNDHRIAMSLWVAGLMAEGETKIKNAECVNISYPDFYKTFDML
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_PROMH
Sequence: MAINLLPPQLANQIAAGEVVERPASVVKELLENSLDAGATTIDIDIDKGGAKLIRIRDNGCGISRDDLKLALARHATSKISTLDDLEAIMSMGFRGEALASISSVSRLTLTSRTASQEEAWQAYAEGRDMTVAVKPAAHPVGSTVEVLDLFYNTPARRKFLRTEKTEFGHIDEVVRRIALSRFDVSINLTHNGKRVRQYRAAKETHQHHRRLSAICGNHFVDQAMQLTWEHGDLAIKGWVEHPLAPVQGSEIQYCYVNGRMMRDRLINHAIRQAYEGYLQGEQQPSYVLYLTVDPHQVDVNVHPAKHEVRFHESRLVHDFIYQAVLSVLRQVTEDTLSLDEEDNGALTATTFPENRQVAGENVFSQPYQAPVTSSTQKKSTGAYQGSAGKGLTDTQKSPQKTLDTRQFGESYQRTQGMLYQKMMQESASDVENKEKIPLFPPRPPLNLVDVGHTTNNNETNVISVVPRSVNASAAQTDYTFGRVLAIYQQKYALIESSQGLGLLALEEADFLLKCAQLLPENENLKPQPLLVPLKVTLSKDEINTFKQFQALISDFGIVIDISHGKATIHAVSLPLRQQNLPELLTKLLAYLATEKLCSKQQIGHWLAKQLSHESGVWSQAQAVGLLADIERLCPQYVRQPSKNLLQLIELQPVVAALNNERSKNANKT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RS13_TREDE
Sequence: MARIAGVDLPNKHVNVSLTYIYGISTSSANKICEATKVDPMKKMNDLDEAELAAIREVIDREYKVEGRLRTEVALNIKRLQDIGCYRGQRHRKGLPVRGQRTRTNARTRKGKKKTVAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: DPO3B_CHLMU
Sequence: MKFVISRNELGNLIKKVQNVVPQSTPIPVLTHVLIESCNDELVFTATDLTVSTRCVVKAKVYESGSVTIPSRRFFQLIRELTEANIEVAANSGEMATITSGSSCFRLLSMGKEDFPMLPDMQNALRFTLDSEQLKDMFQRTSFAVSREESRYVLTGVLLSISNGTMTVVGTDGKRLAKIDTNISLDPSFSGDYIIPIKAVEEIIRMASEDVQSTIFLDQTKIAVECGNTLLVTKLLSGEFPDFSPVISTQSSVQLNLHREELISLLKQVALFTNESSHSVKFSFSPGELTLTANCTKVGEGKVSMAVNYTGETLEIAFNPFFFLDILKHSRDELVQLGISDSYNPGIITDSTRSLFVIMPMRLHDD
What is the function of this protein?
Confers DNA tethering and processivity to DNA polymerases and other proteins.  Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA.  Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity.  The beta chain is required for initiation of replication as well as for processivity of DNA replication.
What are the official names of this protein?
Beta sliding clamp, Beta clamp, Sliding clamp, Beta-clamp processivity factor, DNA polymerase III beta sliding clamp subunit, DNA polymerase III subunit beta.
What is the protein family that this protein belongs to?
Belongs to the beta sliding clamp family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNAS6_MIOTA
Sequence: MVLCFPLLLLLLVLWGPVCLLHAWPKHLTRAHWFEIQHIQPSPLQCNRAMSGINNYTQHCKHQNTFRHDSFQNVAAVCDLLSIICKNRQHNCHQSSKPVNMTDCRLTSGKYPQCRHSAAAQYKFFIIACDPPQKSDPPYKLVPVHLDSIL
What is the function of this protein?
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine.  Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P. aeruginosa, A. baumanii, M. luteus, S. aureus, E. faecalis, E. faecium, S. saprophyticus and E. coli.  Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria.  Probably contributes to urinary tract sterility.  Bactericidal activity is independent of RNase activity.
What are the official names of this protein?
Ribonuclease K6, RNase K6.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted. Lysosome. Cytoplasmic granule.
Protein: GATB_RUEST
Sequence: MLDLTYELPKPKVIAGAKHDWELVIGMEVHAQVSSNAKLFSGASTQFGAEPNSNVAFVDAAMPGMLPVINEYCVEQAVRTGLGLKADINLWSAFDRKNYFYPDLPQGYQISQLYHPIVGEGEVLVELGDGTARMVRIERIHMEQDAGKSIHDMDPSMSFVDLNRTGVCLMEIVSRPDIRGPEEAAAYIAKLRQIMRYLGTCDGNMQNGNLRADVNVSICRPGAYEKYQETQDFSHLGTRCEIKNMNSMRFIQQAIEVEARRQIAIVEAGGEVEQETRLYDPDKGETRSMRSKEEAHDYRYFPDPDLLPLEIEQAWVDDIKSKLPELPDEKKARFIKDFGLTDYDASVLTADLESAHYFDAVAKGRSGKLAANWVINELFGRLKKDDKDITDSPVSPAQLGGVIDLIASDAISGKIAKDLFEIVYTEGGDPAQIVEERGMKQVTDTGAIEAALDEIIAANPAQVEKAKENPKLAGWFVGQVMKATGGKANPKAVNQLVAKKLG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: TGT_PECAS
Sequence: MKYELQTTDGRARRGRLIFERGVVETPAFMPVGTYGTVKGMTPEEVKETGAQILLGNTFHLWLRPGQEIMKLHGDLHDFMNWHGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDSIFLSPEKSMEIQNDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRQRFDELENKNALFGIIQGSVYEDLRDVSVKGLVDIGFDGYAVGGLAVGEPKEDMHRILEHVCPQIPEDKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFVTDGVVKIRNAKHKDDVSSLDEHCDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRQAIEEGKLELFVVDFYQRIGKPIPPLAEKDVAASN
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: SYT_AGRVS
Sequence: MSDTVSLTFPDGSVRSFAAGATGRDVAESISKSLAKKAVAIALDGVVRDLADPVVDGKIEIVTRADPRALELIRHDTAHVLAEAVQEMWPGTQVTIGPVIENGFYYDFAKNEPFTPEDLPKIEKKMKEIIQRNQPFRKEVWSREKAREVFAAKGESYKVELIDAIPEDQDIKIYYQGDWFDPCRGPHMASTGQIGTAFKLMKVAGAYWRGDSNNPMLTRIYGTAFAEQEQLDNYLHILAEAEKRDHRKLGREMDLFHFQEEGPGVVFWHGKGWKMFQSLTAYMRRRLANTYQEVNAPQVLDKSLWETSGHWGWYQENMFAVKSAHAFTNPNDPEADQRVFALKPMNCPGHVQIFKHGLKSYRELPVRLAEFGLVHRYEASGALHGLMRVRGFTQDDAHVFCTEEQMAAECLRINDLILSVYEDFGFKEVVVKLSTRPEKRVGSDELWDRAESVMTEVLKAIEEQSGGRIKTGILPGEGAFYGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDQHSEKTQPVMIHRAICGSMERFLGILIENFAGHMPLWFAPLQVVVATITSEADDYGRDVAEQLRDAGLEVETDFRNEKINYKVREHSVGKVPVIMVCGKREAEERTVNIRRLGSQDQVSMTLDEAIASLVDEATPPDVKRKRAARKPA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_SYNFM
Sequence: MKNRVTVPEIIASKGKRKLSELTAYDYPTALWADQSGIDMLLVGDSLAMVVLGHDDTLSVGMTEMLHHTSAVARGAKRALVIGDMPFMSYQVSVEEALYNAGLFLKEAKAQAVKLEGGRRVAPQVKAMVEAGIPVQGHLGLTPQSSAQFGGFKIQGKTAEAAKILIEDAQILAEAGCFSIVLEGIPSNVAAMVTEAIPVPTIGIGAGPDCDGQVLVIHDVLGLYDRFVPKFVKKYAQLGLTIKEALTKYREEVENGTFPGPEHEFGMAELEAKKLSGLEDKK
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRL2_ONCTS
Sequence: MARRSQGTKLHLAVLCLVVSCHAIGLSDLMERASQRSDKLHSLSTSLNKDLDSHFPPMGRVMMPRPSMCHTSSLQIPKDKEQALRVSENELISLARSLLLAWNDPLLLLSSEAPTLPHPSNGDISSKIRELQDYSKSLGDGLDILVNKMGPSSQYISLIPFKGGDLGNDKTSRLINFHFLMSCFRRDSHKIDSFLKVLRCRATKMRPETC
What are the official names of this protein?
Prolactin-2, Prolactin II, PRL-II.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FRDC_ENT38
Sequence: MTTKRKAYVRPMPSTWWKKLPFYRFYMLREGTAVPAVWFSLELMYGVFALKHGPETWADFVGFLQNPVVLILNLIVLAAALLHTKTWFELAPKAANIIVKGEKMGPEPVIKGLWAVTAVVTAVVLFVALFW
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit C, Fumarate reductase 15 kDa hydrophobic protein, Quinol-fumarate reductase subunit C, QFR subunit C.
What is the protein family that this protein belongs to?
Belongs to the FrdC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNF10_HUMAN
Sequence: MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKRELSYPKNESFNNQSRRSSSQKSKTFNKMPPQRGGGSSKLFSSSFNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQTGHFEGSGHGSWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYTAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLKSVVATESHQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPIHLGDEQHSQYSKLLLASKEQVLHRVVLEEKVALEQQLAEEKHTPESCFIEAAIQELKTREEALSGLAGSRREVTGVVAALEQLVLMAPLAKESVFQPRKGVLEYLSAFDEETTEVCSLDTPSRPLALPLVEEEEAVSEPEPEGLPEACDDLELADDNLKEGTICTESSQQEPITKSGFTRLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLERSPEKISATVVEIAGYSMSEDVRQRHRYLSHLPLTCEFSICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIEIEENKKQGKYPEVHIPLENLQQFPAFNSYTCSSDSALGPTSTEGHGALSISPLSRSPGSHADFLLTPLSPTASQGSPSFCVGSLEEDSPFPSFAQMLRVGKAKADVWPKTAPKKDENSLVPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPATSDPLSEEKGGKKRKKQKQKLLFSTSVVHTK
What is the function of this protein?
Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression.  Acts as a regulator of Schwann cell differentiation and myelination.
What are the official names of this protein?
RING finger protein 10.
What is the protein family that this protein belongs to?
Belongs to the RNF10 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.