PharMolix/UniProtQA huggingface dataset:
Protein: RLP24_RAT
Sequence: MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPVKYQRELWNKTIDAMKRVEEIKQRRQAKFIMNRLKKNKELQKVQDIREVKQNIHLIRAPLAGKGKQLEEKMVQQLQEDVDMEDAS
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.  Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).
What are the official names of this protein?
Probable ribosome biogenesis protein RLP24, Ribosomal L24 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: VF358_IIV3
Sequence: MDYALEQAIKTNLVLLVEFILEKHPTIERHTVYQKVEQLTSIQLGKVSSAKQSSKSTTTTTPKTGGRKKIRDAIERKKATIIVRKSQWSNYVLTVPDECHNDENLTDLIESNFVMDVTTKTIVATETKDGALRPLNRETIDICNKHKLRYEVPLNLNLYDNEDSTDAALVTEMEELGLTYASSDDEEEKNQN
What are the official names of this protein?
Uncharacterized protein 083L.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 358L family.
Protein: LOLA_VIBCM
Sequence: MNKWLALLFCSFSAIAAPKDTLSERLAMSEGFSATFNQQVLSPEGKVILTGNGKVDIARPSLFRWETETPDENLLVSDGTTLWHFDPFVEQVTLYRAEEALEQTPFVLLTRNKASDWDAYHVEEKGDVFTLTPTALDSNQGRFQITISEKGVVQGFKVIEQDGQQSEFTFSKVKQQKPNASVFNYKVPKGVEVDDQRN
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: VGB_BORPA
Sequence: MNQVEMTEFPVGKPQEALYGVASTPDGALWFTLAKGNAIGRLSPDGAVSRFPLPHTDGQPTTITCGPDGRPWFTLSSANAIGRLAPDGALRMFELPRPASRPFGIAGGHDGCLWFAEMAGDRIGRITIDGDIEEYDLPVKGGYPSCMAAGRDGLMWFTLNQAGAVGSISATAAPRIFPLGAADAAPVGIASDAQGALWIAQAGNGAIVRFDAGGRITEFPLHSRAARPHAIAADAAGNLWFTEWGANRIGRISEAGDLAGYELAAPGSEPHGIAIDPHGCVWAALETGRLVRLQASPRD
What is the function of this protein?
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
What are the official names of this protein?
Virginiamycin B lyase, Streptogramin B lyase.
What is the protein family that this protein belongs to?
Belongs to the Vgb family.
Protein: FAR8_LOBRE
Sequence: ARTDNFVRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-8, FMRFa-8.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: STPAP_BOVIN
Sequence: MAAVDSDIEPLPRGGFRCCLCHITTANQPSLDAHLGGRKHRHLVELRATRKAQGLRSVFVSGFPRDVDSTQLSEYFQAFGPVASVVMDKDKGVFAIVEMGDLGAREAVLSQPQHSLGGRRLRVRPREQIEFQSPASRSPKRVAPDSHQLIKALAEAPDVEAQMVKLVGLRELSEAERQLRSLVVALMQEVFAEFFPGCVVHPFGSSINSFDVHGCDLDLFLDLGDLDEPQPAPKAPESPSLDSALASPLDPQALACTPASPPDSQPPASPQDSEALDFEAPSSSLAPRTPDSALASETLASPRSLPPASPLQEDQGDGDQGKAVELAEALKGEKAEGGAMLELVGSILRGCVPGVYRVQTVPSARCPVVKFCHRPSGLHGDISLSNRLALHNSRFLSLCSELDGRVRPLVYTLRCWAQGRGLSGSGPLLNNYALTLLVIYFLQTRDPPVLPTVSQLTQKAGEQVEVDGWDCSFPRDASRLEPSTNKEPLSSLLAQFFSCVSCWDLRGSLLSLREGQALSVAGGLPSNLSEGLRLGPMNLQDPFDLSHNVAANVTSRVAGRLQNCCRAAANYCRSLQYQRRSSRGRDWGLLPLLQPSSPSSILSATPIPLPPASFTQLTAVLAQVLREALGCHIEQGTKRLRSEGGGPGEPPQGGTSKRAKLDGQKKSCEEGPEEQQGCAGEHGEDGVEEMVIEVGESVQDWVMRSPGQLGELPLMTGKHLATREEGQSGTAALAKQGPRGPEAACEGSQAEAEKRVSLTVSWRCALWHRVWQGRRRARRRLQQQIKEGGGSGAGSGAEWLATEAQVTRELRGLSSTEQRPEAEPLLTFVASTSQADQSLTVTPLQDSQGLFPDLHHFLQVFLPQALRNLLK
What is the function of this protein?
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs.  Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1.  In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs.  In addition to adenylyltransferase activity, also has uridylyltransferase activity.  However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase.  Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA.  Not involved in replication-dependent histone mRNA degradation.
What are the official names of this protein?
Speckle targeted PIP5K1A-regulated poly(A) polymerase, Star-PAP, RNA-binding motif protein 21, RNA-binding protein 21, U6 snRNA-specific terminal uridylyltransferase 1, U6-TUTase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus speckle.
Protein: MUTS_ECOLI
Sequence: MSAIENFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGDPATSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESISPNAAATQVDGTQMSLLSVPEETSPAVEALENLDPDSLTPRQALEWIYRLKSLV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RPN1_SCHPO
Sequence: MSSKDISSKSPSGNDALNDKKGTKTSETNDRNSTNNTKERDELEDLSEEDLQLKNDLELLVQAVQDATPELVGSSLTQLKEIIRTSTSSMTAVPKPLKFLRPHYFTLVKIYDSWPQSPQKTQLADILSVLGMSYSNTSKHESLKYRLQGVTTDPSLWGHEYVRHLASEIEEEFASRQEEEAPTDDLMELALTIVPFFLTHNAEADAIDLLQELGAIEKVVPFVELDNASRVCLYITSCVNLLPFPEDVAMLRTAHAIYRKFDQLTQALNVAIRLDDMSLIKEDCEAATDPLLKKQMSYMLARQQIPMDMGDEELNDALNNTHLSDHFHYLGKELNLMDPKVPEDIFKTHLEVARTGLGASGVYSAKQNLANTFVNALVNAGYSNDRLILVDDEKTSWIYKNKESGLISATASIGLLQLWNVDMGLSLLDKYLYSSEENTKAGALLGIGVTNVAVRNEADPAMAILSEYLETGSVKLRASAILGLGLAYSGANREDLLDMLSPIVTDTDCPMQLSCLAALSLGLIFVGTCNGDVASTILQTLMEREESAQNDQWGRFMALGLALLFNGKQDLADATVETLKAIEGKIARQAEILVDICSYAGTGNVLHIQKLLHICSEPPSDDAKESETTIQTFAALGVATIAMGEDIGAEMVLRHFDHMMHYGEPSIRKAIPLALGLLSASNPQMRIFDTLSRYSHDNDLDVAYNAIFAMGLVGAGTSNARLAQLLRQLASYYHKESNALFMVRIAQGLLYLGKGTMTLNPYHTERQILGQTAFAGLMTVVLAMLDANTFVLDTSHWLLYAITLAIRPRMLITLGEDGQYLPVSVRVGQAVDVVGQAGRPKVITGWVTHTTPVLLHHNERAELATEAYTPLTSLEGIVILKKNTEDIEMTA
What is the function of this protein?
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
What are the official names of this protein?
26S proteasome regulatory subunit rpn1, 19S regulatory cap region of 26S protease subunit 2, Proteasome non-ATPase subunit mts4.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S2 family.
Protein: FDHE_ECOLC
Sequence: MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNLYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEASAQGKPPLDIHVLPRDKHWQKLLMALIAELKPEMSGPALAVIENLEKASTQELEDMASALFASDFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVCGSMPVSSMVQIGTTQGLRYLHCNLCETEWHVVRVKCSNCEQSGKLHYWSLDDEQAAIKAESCDDCGTYLKILYQEKDPKIEAVADDLASLVLDARMEQEGYARSSINPFLFPGEGE
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBP2_LISMO
Sequence: MKKLWKKGLVAFLALTLIFQLIPGFASAADSRLKDGGEYQVQVNFYKDNTGKTTKESSEADKYIDHTATIKVENGQPYMYLTITNSTWWQTMAVSKNGTRPEKPAQADVYQDRYEDVQTVSTDAAKDTRVEKFKLSSLDDVIFSYMHIKVDAISYDHWYQVDLTIDPSTFKVISEPAVTTPVTLSDGIYTIPFVAKKANDDSNSSMQNYFNNPAWLKVKNGKKMVAMTVNDNKTVTALKTTLAGTLQDVKVVSEDKDANTRIVEFEVEDLNQPLAAHVNYEAPFNGSVYKGQADFRYVFDTAKATAASSYPGSDETPPVVNPGETNPPVTKPDPGTTNPPVTTPPTTPSKPAVVDPKNLLNNHTYSIDFDVFKDGTTETSMMESYVMKPALIKVENNQPYVYLTLTNSSWIKTFQYKVNGVWKDMEVVSGDINKNTRTVKYPVKDGTANTDVKTHVLIEDMPGFSYDHEYTVQVKLNAATIKDITGKDVTLKEPVKKDILNTGNVASNNNAGPKLAKPDFDDTNSVQKTASKTEKNAKTNDSSSMVWYITLFGASFLYLAYRLKRKRLS
What is the function of this protein?
Acts as an extracellular and cell wall-bound hemophore; scavenges host heme and hemoglobin from the environment and also serves as a cell wall receptor for both (Probable).  At low hemin (Hn) and hemoglobin (Hb) concentrations adsorbs Hn/Hb and presumably directs it to membrane transporters (Probable).  Soluble Hbp2 can probably pass Hn/Hb to cell wall-anchored Hbp2, and both forms can accept Hn/Hb from Hbp1 (PubMed:25315777).  May be involved in crossing the digestive barrier in infected animals (PubMed:15661014).  Binds host hemin (Probable) (PubMed:21545655, PubMed:25315777).  Binds host hemoglobin with affinity in the nanomolar range (PubMed:25315777).
What are the official names of this protein?
Hemin/hemoglobin-binding protein 2, Hn/Hb-binding protein 2, P64, Surface virulence-associated protein A.
What are the subcellular locations of this protein?
Cell surface. Secreted, cell wall; Peptidoglycan-anchor. Secreted. Note=Most protein is secreted (PubMed:15028680, PubMed:15661014). Cell wall attachment is iron-regulated, only occurring when iron levels are low or fur is deleted (PubMed:15661014). Cell wall-anchored protein localizes to one cell pole or laterally (PubMed:15028680). Protein does not have to be cell wall-anchored for virulence (PubMed:15028680). During exponential growth detected on the cell surface as a series of dots in a helical pattern, it is excluded from the septum (PubMed:21725001). The helical pattern of InlA does not overlap with that of InlH, InlJ or Hbp2 (PubMed:21725001). Under iron-limiting conditions accumulates at the old cell pole (PubMed:21725001).
Protein: LIPB_BRASO
Sequence: MVNGRETLDLTPFAGPPGNVAAWRISDALVDYAEATAFMEARAAAIAAHQAEELVWLLEHPPVYTSGTSGKPEDLRDPRFPFIATGRGGQVTYHGPGQRVAYVMLDLKRRRPDVRAYVAALEETIIRTLDAFNVRGERREDRVGVWVKRPDKGEGHEDKIAAIGVRLKRWVTFHGIAINVEPDLSHFQAIVPCGVTDPRYGVTSLVDLGLPVTMADVDVALRQAFESVFGATRAILPETA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_COREF
Sequence: MKNEIHPDYHPVVFQDAGTGFQFLTRSTATSDRTIAWEDGNEYPLIVVDVTSESHPFWTGAQRVMDTAGRVEKFERRFGGMARRKKKA
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: SOMA1_ONCNE
Sequence: MGQVFLLMPVLLASCFLSQGAAIENQRLFNIAVSRVQHLHLLAQKMFNDFDGTLLPDERRQLNKIFLLDFCISDSIVSPVDKHETQKSSVLKLLHISFRLIESWEYPSQTLIISNSLMVRNANQISEKLSDLKVGINLLITGSQDGVLSLDDNDSQHLPPYGNYYQNLGGEGNVRRNYELLACFKKDMHKVETYLTVAKCRKSLEANCTL
What is the function of this protein?
Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes.  Implicated as an osmoregulatory substance important for seawater adaptation.
What are the official names of this protein?
Somatotropin-1, Growth hormone I, Somatotropin I.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SLD2_PHANO
Sequence: MSITETEQRCNELRNDLKLWEKNFAAQNDGRKAGRDDIKANEEISNKYKEYNKLRGKLTAQSAPQTPSKRTASRKATRDAERTPKAAPKYQTSTPLKRKRAEELASEPIPQSPEFLSPQGPSVIGPTPQRDGIVLGLFDMLPAGTPSKRRAVLGDVELNILQTPSRRSQEAASETSLESRARGERTPVSVGKRFMLNQFVTPKKRKMEEEGTPSSTTRGLATPAFLRRGNLLGPIDEADETTPRPAPWKRRGLGRSLSAMIQAMKKDEDDKLDEEADIMREMEMEEAGISMPPKKLRVPQILVEDSQAAMPLGPDRGLETEEDEDEEPELGPDGKPRRVWKKKGLKRQTRRVIMRPNFIKSKLESALQLHDDSEDDQDKVAETQATGHAADDVDSEDDISDYASDVSHTPKQRKVQKKKTEEVKDQPKEGGVKTAARKIKATAHANFRRLKIKSSTGAKGGAKGKFGRRR
What is the function of this protein?
Has a role in the initiation of DNA replication.  Required at S-phase checkpoint (By similarity).
What are the official names of this protein?
DNA replication regulator SLD2.
What is the protein family that this protein belongs to?
Belongs to the SLD2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CLPP_BURP0
Sequence: MINRAQLLDTLASQAPRDFEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFMVGEVNDQTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGMAIYDTMQFVKPDVSTLCMGLAASMGAFLLASGAKGKRYALPNARVMIHQPLGGARGQASDIEIQAREILYLRDRLNHLLAHHTGQDVERIARDTDRDNFMSSEDAKAYGLIDHVSTKRP
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFCL_THEPD
Sequence: MSAVKVQLVPWTEKYRPARIADVVGNEEAKKKYVAWINSWVKGKPSKKAALLYGPPGSGKTSIVHATAKEFSWELIELNASDVRTREALQQRLLGALNTRSVLGYSGKIILLDEVDGISTKEDAGGLQAIVELIEKSNWPIVLTANDPWDPKLRPLRDLCELIEFKKIGKRDIMKVLENICSKEGVECSREVLSAIADNAKGDLRAAINDLQSLAMGKKTISLADLQILGDRAEQETIFDIVRSVLTAKYPEQALAVTRLPSLDYEMLMQWLSENIVYQYEPSLQAIADAYDALSWADIMLTRMKREQQWALLSYALELMTAGVASARERPPFKFVKYSFPEKLRILARSKEKREKFVRAVRGAAAKIHVSTSKFRTDVLPYLRVIYEHDKKRALEILRNLGVPEDALELATQ
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C large subunit, RFC large subunit, Clamp loader large subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcL subfamily.
Protein: PNCB_SHISS
Sequence: MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDLLGIYADAIREQIQAMQHLRLQDDEYQWLSALPFFKADYLNWLREFRFNPEQVTVSNDNGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKLVDFSALTAGLDMSRFHLMDFGTRRRFSREVQETIVKRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQRAALAAWLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLGIDPQSKTLVFSDNLDLRKAVELYRHFSSRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPHIKKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: CYB_GENPA
Sequence: MTNIRKSHPLAKIINESFIDLPAPSNISAWWNFGSLLGVCLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWIIRYIHANGASMFFICLFMHVGRGVYYGSFTFTETWNIGILLMFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIISALAAVHLLFLHETGSNNPSGVVSDSDKIPFHPYYTIKDILGLLLLILVLMLLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILAIVPLLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFITIGQLASILYFSIFLILMPVSGIIENRLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LEXA_CLOBM
Sequence: MNKSRIDKQNEVYNFIKLQIKEKGYPPSVREICKAVGLSSTSSVHFHLKRLEKEGLIKRDSSKTRAIEIVDPTSKKEVINVPIVGTITAGNPILAIENIEDVFPLPIDYVKNTKDLFMLKVSGESMIEAGILDGDLAIIEKTDSANNGDIVVALIDNEATLKRFFKESSYIRLQPENKSMKPIILENCKVLGRLVGIYRKY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: ARLY2_ALKCK
Sequence: MSKLWGGRFTKTAEQWVDEFGASIGFDQQLVEEDITGSIAHVTMLAKQHILSEEEAAQIKNGLKTLQKKAAAGELVFSAAQEDIHLNLEKLLIDEIGPVGGKLHTGRSRNDQVATDMHLYLRTQTEEIMEAIRTLQAALVKQAEGHVETLIPGYTHLQRAQPVSFAHHLLAYFWMLERDYGRLQDSLKRVNISPLGAGALAGTTFPIDRAYTAELLHFEGIYENSLDAVSDRDFIVEFLAASATLMMHLSRLCEELILWSAQEFQFIEIDDAFATGSSIMPQKKNPDMAELIRGKTGRVYGSLFSLLTTLKGLPLAYNKDMQEDKEGMFDTVKTVKGSLRIFAGMIETITVNTDAMAKAVTSDFSNATELADYLATKGMPFREAHEVVGKLVLTAIEKGVYLLDLPIEVYKEASSLFADDIYEVLQPKTVVGRRNSAGGTGFEQVKLALGKANDLLSQSIKG
What are the official names of this protein?
Argininosuccinate lyase 2, ASAL 2, Arginosuccinase 2.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZAPB_ECOUT
Sequence: MTMSLEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNSLSQEVQNAQHQREELERENNHLKEQQNGWQERLQALLGRMEEV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: APOE_PANTR
Sequence: MKVLWAALLVTFLAGCQAKVEQVVETEPEPELHQQAEWQSGQRWELALGHFWDYLRWVQTLSEQVQEELLSSQVTQELTALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAMGTSAAPVPSDNH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: ESF2_GIBZE
Sequence: MAPETKNDFLEIADSDADSDIGYNSEEDDMQKGGRGAKRRKVESDDEDDPGSDIGSDDEDEATEKDSKKTQEEDKKEDQPEKPKRKSKDTTSTELPDVTRTLTKKNLVASEAAIKKSGVVYLSRIPPFMKPAKLRSLLEPYGTINRIFLAPEDPASHARRVRAGGNKKRSYTEGWVEFTKKKDAKAVCDLLNARTIGGKKGSYYHDDLWNLLYLKGFKWHNLTEQIAAENAERSSRMRAEISKSTKENKEFVRNVEKAKMLDGMAVKAKAKKRKAETHTEGQEDESVRQVKRSFKQVPLAKKKMDGEDQPAEVTRVLSKIF
What is the function of this protein?
Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis.  Required for the early cleavages at sites A0, A1 and A2 (By similarity).
What are the official names of this protein?
Pre-rRNA-processing protein ESF2, 18S rRNA factor 2.
What is the protein family that this protein belongs to?
Belongs to the ESF2/ABP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.