PharMolix/UniProtQA huggingface dataset:
Protein: SDHF3_DEBHA
Sequence: MRPSLVRLVRPRRPERKTSPILPPLKLYKALLRAHANKLPVELRPLGDQYVKAEFKAHKNIDNPLHIVGFLAQWQDYLKGIDGGEWINGKLSQQDLEKMSPEQIGQLHELMEEAKKAGASE
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants.  May act together with SDHAF1.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 3, mitochondrial, SDH assembly factor 3, SDHAF3.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family. SDHAF3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: WBBL_MYCTU
Sequence: MTDVLPVVAVTYSPGPHLERFLASLSLATERPVSVLLADNGSTDGTPQAAVQRYPNVRLLPTGANLGYGTAVNRTIAQLGEMAGDAGEPWVDDWVIVANPDVQWGPGSIDALLDAASRWPRAGALGPLIRDPDGSVYPSARQMPSLIRGGMHAVLGPFWPRNPWTTAYRQERLEPSERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMEDVDLGDRLGKAGWLSVYVPSAEVLHHKAHSTGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLALRSHLMVRSSLRRSRRRKLKLVEGRH
What is the function of this protein?
Involved in the biosynthesis of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall.  Catalyzes the transfer of the rhamnosyl moiety from dTDP-rhamnosyl (dTDP-Rha) onto the decaprenyl-pyrophosphoryl-GlcNAc (C50-PP-GlcNAc), yielding rhamnosyl-decaprenyl-pyrophosphoryl-GlcNAc (Rha-C50-PP-GlcNAc).
What are the official names of this protein?
N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase, Rhamnosyltransferase WbbL, dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol, alpha-3-L-rhamnosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: NSP4_RDVF
Sequence: MNQSRSFVTGRGRDLSRTPSALSSNSETPGSMSSPSEGKTNAWVNSAYVSNFPALGQSQGLPSHKCSALALRSSQTTYIINFPRQHWNIMTFPNQSEAILATVASYAKDLDGKNSFAVFDTLKMPWSCRLGEKSCSGIDTLGHLADVHMHVLDPAEAEGKNLSDSETVYVYVTPPNLTDVKPTTIVLTECAANAKSANDLRQYIVTQLRKMPSLPFGCTTYAPGFLSDGVCKEHPNLFTSEELGAKIKVLTKLLIRCATSMSQDGSNAFCPKHPKVKIVHESNATSYILFNRPNGMVATNLILSDLPDDDCPTCWILKLAISEARYYALDGHHRCRSRIITPSVFRYLASIVIRVSMDSVLAPSDASSTDHAALVNMMCGIIQNTPAMRHVGISTGSEKVNNRSMRVIIMQENADRATQMSALYHLFLDYFGALNGWGFYFCSLTSLYGEFHGFSVGFSGEITHVNVASVIAKNWDTQSGIDNILEFKTITIPVHNEDIVCMVERTLAESFEVVINEHFNGASTIKVRRNGGDSRFNFTISNPRDAFLLLQKAVVDGGILQKILCRAMLKAIASLALRADREVQDVSFSFVLKMSLNPVNKSDPKSSELAHAAQMNSLPEFLASTPFTMQLGTLRDALLKKTGNVTVINMARTTEEVSNDALQEILKSIGGNSMTLDDPAEPLSDIESIPDPPPRSWASEDEAVNSPQTYSSRRKARKARAASKLSK
What are the official names of this protein?
Non-structural protein 4, Pns4.
Protein: EFGM_COPC7
Sequence: MFLGRAASRTCRHSQPLRVAARAKSTTTAVASSSWHQYGVTGGILASTSSSSRTVVNPAKQRRWVRMASTATATKPTEEASSSDQPPAPAHKLTDNDVKRLTFQRNIGISAHIDSGKTTLSERILFYTGKIREIHEVRGRDAVGAKMDNMDLEREKGITIQSAATFCDWEATNPEDGSKQKYSINVIDTPGHVDFTIEVERALRVLDGAILVLCAVAGVQSQTTTVDRQMRRYNVPRISFINKMDRPGANPWRIVNQIRTKLRMPAAAVQVPIGTEDELKGVVDLVHWRALYNEGPKGTEIRVSKDIPESVAELAKQKRAELIEQLAEVDEEIGELFLMDETPTNRQIADAIRRATIDLKFSPVFMGSAMKNTGVQFLLDGVCEYLPNPSEREVLAIDNKNLDPATASSQASQTPNVPLVPAAAAPFVGLAFKLEEGRFGQLTYVRVYQGTLKKAMNIWNVRTGKKVKVPRLVRMHSDEMEDIDSIGPGEICAMFGVECSSGDTFTDGTSTYSMTSMFVPEPVISLAIKPKGQETPNFSRALNRFQKEDPTFRVHIDQESKETIISGMGELHLEIYVERMRREYNTECITGKPRVAFRETITQRAEFAYTHKKQTGGAGQFARVIGYIEPMEMDPETGKDVAFENLVMGGNIPTNFIPAVEKGFYEALEKGSLTGNPITGVRFVLKDGAFHAVDSSELAFRLATIGAFREAFKKARGIVLEPVMTVDVVAPSEFQSNVIGGLNTRRGTIVDSEVRDDEFTAVAEVALNDMFGYSNQLRGSTQGKGEFSMEYKHHAPVLPNVQKELEEAYQKTLPQSKK
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GCH1_ENTFA
Sequence: MEQEKQAQIEQAVTTILEAVGEDTQRAGLIDTPKRVAKMYAEVFSGLTEPEFDDYKLFDSLNEGEMVLVKDIAFYSMCEHHLLPFYGKVHVAYLPEGGKVLGLSKLPRLVEHCAKRPTVQEDLTVTIARKLQENIPVKGIAVAIEAEHMCMTMRGVKTPQSSTKTFQFTGLFKEQEWKNQFLMEIR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: UPPP_AFIC5
Sequence: MLFDLFKALVLGIVEGVTEFLPVSSTGHILLAERIFDLDQDNFWKTFAVLIQLGAILAILAIYFQRLWRVATHMFTDPAARRFVIGVLVAFLPAVILGLIFGTFIKEVLFNPWVVCFSLIAGGAVLLWVDQQDVNPRHHDAMAFPLPMYLGIGIAQCAAMVPGVSRSGASIVAAMLFGADKRAAAEFSFFLAIPTMLGAFVYDVYKSRGDMTMDHAFIIIVGFVVSFITAIVVVKTFLDFVTKNGFTFFAWWRVIVGTLGLIALALGA
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASTC_ECOSM
Sequence: MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIHHAAYNDINSASALIDDATCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYAYMHYGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLINTPEMLNGVKQRHDWFVERLNSINHHYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
What is the function of this protein?
Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate.  Can also act as an acetylornithine aminotransferase.
What are the official names of this protein?
Succinylornithine transaminase, Succinylornithine aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily.
Protein: PLSY_SHIB3
Sequence: MSAIAPGMILIAYLCGSISSAILVCRLCGLPDPRTSGSGNPGATNVLRIGGKGAAVAVLIFDVLKGMLPVWGAYELGVSPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKFKRKREKDPE
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HXA13_CHICK
Sequence: MFLYDNSLDEINKNMDGFHAGSNFAAAAAANPCRNLMAHPAPLAAPSAAAYTSSEAPAAGMAEPAVKQCSPCSAAVQSSSGAALPYGYFGSGYYPCRMTHHNAIKSCAQPASTFADKYMDTSVSGEEFTSRAKEFAFYQGYAAGPYQPVPGYLDVPVVPTIGGPGEPRHDSLLPMDSYQPWAITNGWNGQVYCPKEQSQPPHLWKSTLPDVVSHPSDANSYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTNLSERQVTIWFQNRRVKEKKVINKLKTTS
What is the function of this protein?
Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A13.
What is the protein family that this protein belongs to?
Belongs to the Abd-B homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CM3B_CONPI
Sequence: ERVCCGYPMSCKSRACKPSYCC
What is the function of this protein?
Mu-conotoxins block voltage-gated sodium channels (Nav) (By similarity).  Intraperitoneal injection into fish (1 nmol) provokes weakening and difficulty in swimming after 20 min.
What are the official names of this protein?
Mu-conotoxin-like pr3b.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRB_STAA3
Sequence: MNHLLSMEHLSTDQIYKLIQKASQFKSGERQLPNFEGKYVANLFFENSTRTKCSFEMAELKLGLKTISFETSTSSVSKGESLYDTCKTLESIGCDLLVIRHPFNNYYEKLANINIPIANAGDGSGQHPTQSLLDLMTIYEEYGYFEGLNVLICGDIKNSRVARSNYHSLKALGANVMFNSPNAWIDDSLEAPYVNIDDVIETVDIVMLLRIQHERHGLAEETRFAADDYHQKHGLNEVRYNKLQEHAIVMHPAPVNRGVEIQSDLVEASKSRIFKQMENGVYLRMAVIDELLK
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RL33_BAUCH
Sequence: MAKGVREKIKLVSSAGTHHFYTTTKNKRLKLEKLELKKFDPVVRKHVIYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PGCA_STAHJ
Sequence: MKDNWMKYKDDSLVASFYDSQTTTFQEQGFETELAFGTAGIRGQFGLGPGRLNRYTIQRLALGIANYLKDKEDNPSIVIHYDIRHLSSEFAHIITQILTSKGIKVYLADVYKTTPQLSFAVRYLQTSAGIMITASHNPKDYNGIKVYGADGAQLDEDTSLEVAQYINNLGNPLELNIDLNQELIEKNTFDLQEAVYDSYINEITNLIGDIPQSDLKVVYTSLHGTGVPIIPDVLKHLNFQNVSLVELQCELDPNFSSVKSANPEEREAFDLAIQQAHDLEANLIIATDPDVDRMGFVERDTNGQTYYFGGSEIGALLIKYLLEYTNVPNHSVVIQSIVSGELGKRLAQQHEVTVKEVLIGFKHIAKAIRELDDTESFLFAYEESYGYLADDFVRDKDAIQIVPLIIKYTSILKNEGKTLHDALKEIHREVGQYRDKPMSKVFEGREGQQQINALMDKLRRNIPDVIAGLKVIAVEDYETLKRNYKEDNTEEAISLPQANVIRILFKEGFIALRPSGTEPKLKFYLSLNVDNFEQVSQDIYNYIFGDTE
What is the function of this protein?
Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate.  This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i. e.  a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) (By similarity).
What are the official names of this protein?
Phosphoglucomutase, PGM, Alpha-phosphoglucomutase, Glucose phosphomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: Y1196_THEGJ
Sequence: MAEDIEEIRKRKLMELQKRYLEQQKAQEEAIKREMELQAQIDAIMRKILTPDARERLGRVKLVKPELARQVELVLVQLYQAGQIREPIDDAKLKKILAQIDARTRREFRIKW
What are the official names of this protein?
DNA-binding protein TGAM_1196.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: Y330_STRPQ
Sequence: MRKSFYSWLMTQRNPKSNEPVAILADLVFDDTTFPKHTNDFELISRYLEDQASFSFNLGQFDEIWEDYLAH
What are the official names of this protein?
UPF0346 protein SPs1527.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: MNMA_GLUDA
Sequence: MRIMVAMSGGVDSSVVAARLVAEGHEVVGATLQLYDSRESARKGACCAGRDIHDARRVADRLGIPHYVIDAETRFRQSVIETFADAYAGGETPVPCVACNQGVKFTDLLGIARDLGAEAMATGHYVRRIEGPDGAELHRPVDEGRDQSWFLFATTRQQLEFLRFPLGDMPDKAAVRAEAERFGLSVAAKPDSQDLCFVPDGSYARVVEALRPEMAGEGEIVDGSGRVVGRHDGVTRFTVGQSRRLGDAAMRDGARQMVVGIDPASRRVVIGPRTGSAVRDLSLRDMNWLIDPPEGDLRCLVQIRAREAARPATVRRTADGASVTLDEAAMPAPGQACVLYDGSRVLGGGFIRRREMAGAAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMC_PECAS
Sequence: MANLPIQHASLSWNAQGTPVSQQFDDVYFSNQDGLAETRYVFLQGNQFPERFGTHPRTACVIAETGFGTGLNFLTLWQAFAHFRQQQPQATLRHLHFISFEKFPLRQHDLAAAHAQWPELAEFADELRQQWPLALPGCHRLILAQGSITLDLWFGDVNVILPELDDTQNHQVDAWFLDGFAPSKNPDMWTDNLFQAMARLCRKEGTFATFTAAGFVRRGLQQAGFHVSKVKGFGQKREMLSGLLPDTLPITSPTPWYSRPAASTTDDIAIIGGGIASVLTALALQRRGANVTLYCAESQPATGASGNRQGALYPLLNNRHDAVSRFFSLAFDFAHRSYSALAQQGLEFEHQWCGVSQLAWDEKSARKIEQILQGEWPEELVVSVDAQQLEKQSGLNPGVNGITYPDGGWLCPAELTAAALKLAQQNGLSVQMSTAVSALEKTDSGWALTLSAGQQVNHAVVVLANGHHITDWPQTRHLPGYAVRGQVSHIPTNPVLGQLKHVLCYDGYLTPVSPQHQTHCIGASYLRGQAHGDYREEEQQENRQRLLNCLPNADWAKTVDISDAQARQGVRCALRDHLPLIGAVPNYEQTLKEYENRLHPQHRADTVSSAPYWQDLFIIGALGSRGLCSAPLAAEILASQMYAEPLPLDRDTLAALNPNRFWIRKLLKGKPVTHD
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEX2_HUMAN
Sequence: MASRKENAKSANRVLRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKACLWVFLWRFTIYSKNATVGQSVLNIKYKNDFSPNLRYQPPSKNQKIWYAVCTIGGRWLEERCYDLFRNHHLASFGKVKQCVNFVIGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVFCKPQNICEVGFEYMNRELLWHGFAEFLIFLLPLINVQKLKAKLSSWCIPLTGAPNSDNTLATSGKECALCGEWPTMPHTIGCEHIFCYFCAKSSFLFDVYFTCPKCGTEVHSLQPLKSGIEMSEVNAL
What is the function of this protein?
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292).  The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity).  PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity).  PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity).  Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 (PubMed:27597759).  Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (PubMed:34903883).
What are the official names of this protein?
Peroxisome biogenesis factor 2, 35 kDa peroxisomal membrane protein, Peroxin-2, Peroxisomal membrane protein 3, Peroxisome assembly factor 1, PAF-1, RING finger protein 72.
What is the protein family that this protein belongs to?
Belongs to the pex2/pex10/pex12 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: TA4_EIMTE
Sequence: MARLSFVSLLSLSLLFGQQAVRAQDYPTAVTLDCKEAMNKLRKAAGLPAFEDAVGDTFVLPAYSHEESRAAPVAETLWKTEICPKVLGGGRSRNVTEAVKLTGNFAYYPVTDGKKECSDAVEYWKGGLSQFNDTIPPTFQALNDPVVYNDRAVSFVALYNPKTSPVVSCVLLQCPNAGVGGRRLAAGTTDAVICLTNPAPLEARSQPFDDEQWKKIVDSLSLSEEEEEKGGVSPVVPSVALISAAVISAFALF
What are the official names of this protein?
Sporulated oocyst TA4 antigen, Major sporozoite surface antigen.
What are the subcellular locations of this protein?
Note=Surface of sporozoites.
Protein: WDR73_MOUSE
Sequence: MELAEDWLVESLRLYQDFHAFDLSGATRVLEWIGEKGVFVAGYESLKKNEILHLILPLRLSVQENQGLHPERDFKVRHGGFSDRSVFDLKHVPDTRLLVTSGLPGCYIQMWQVREDNDVIEAVSTIDVQDKEESLWPRVSVFCSKAPGILHGARLSGLRTVDVESQKITYSSGTADSESLSCLQVLDANTFAFCGNSGRLGLVDTRQKWAALETVSPGSGCSGERWCAEVRNKGQGPGPCIASLGSDGQLCLLDSRNLCHPVSSAQCPVFKPSPDPELLRVTWAPGLDNCLAISGFDGTVQIYDVTSWDGKKTQAEPLFTHKGHIFLDGNDVDSAPLVTTHTWHPRKPRTLLSAASDSSLHVWDWVDLQAS
What is the function of this protein?
May play a role in the regulation of microtubule organization and dynamics.
What are the official names of this protein?
WD repeat-containing protein 73.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR73 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During interphase, located in the cytosol. During mitosis, accumulates at the spindle poles and microtubule asters and later in the cleavage furrow.
Protein: MARC2_MOUSE
Sequence: MGSSSSTALARLGLPGQPRSTWLGVAALGLAAVALGTVAWRRTRPRRRRQLQQVGTVSKVWIYPIKSCKGVSVCETECTDMGLRCGKVRDRFWMVVKEDGHMVTARQEPRLVLVSITLENNYLTLEAPGMEQIVLPIKLPSSNKIHNCRLFGLDIKGRDCGDEVAQWFTNYLKTQAYRLVQFDTSMKGRTTKKLYPSESYLQNYEVAYPDCSPVHLISEASLVDLNTRLKKKVKMEYFRPNIVVSGCEAFEEDTWDELLIGDVEMKRVLSCPRCVLTTVDPDTGIIDRKEPLETLKSYRLCDPSVKSIYQSSPLFGMYFSVEKLGSLRVGDPVYRMVD
What is the function of this protein?
Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles.  As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability.  May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis.  Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.
What are the official names of this protein?
Mitochondrial amidoxime reducing component 2, mARC2, Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, MOSC domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome.
Protein: BPT_XYLF2
Sequence: MAIDSKPHDDLQLFKTNLHPCGYWPDRWASDLVMDPNDPRLGAIYPQTLAWGFRRSGNLLYRPHCEHCNACVPVRVNVNAFVPNRSQRRCLARNATLVTRIVPAERNAEQLSLYRRYLHQRHPDGGMDGHGAIEFDQFLIGPWGYGRFMEIREPATNGTPGQLLAVAVTDLTHQALSAVYTFYEPNAAARGLGTLAILHQIHWAQREQRPYLYLGYWIKDHFKMDYKRRFQKLEIYDGYRWRPFSTTYPTTHTL
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMR1_SCHPO
Sequence: MAGVSPVVNHPYTTNSGDFIELGMEPAQKVQVDLDEAFNQMLHDGKVEEVVEAINGSPDLLSESDVENAKNNEHTYDIDNKNFNFEPKNSVNKTETIREELDQAASKILIETLDLHQKEGFEETIVTEEATDAVDLEAKGTTHGENDLDEVPTELNELANEVVDVDDVVSPSSELNAQSVNNILPISDDPKDSTSEAETRDFNWLSKGIVIFPNSSECAFYGNNNDEGMYLYSNGDDLNENTIEDFFGLVRARLESLNLLDSDSELLCEFPDLSLKINEDNVYASQIHLVDILEILTVHCDLEESFSIVFSTQPRFIARYNELVQAVSSSSNSEIDEVEDAETIDSKILEKRNDLNNEEPNSVVAEDGSEIITLDENDQSPNEATEKLRDNDLEESLIKDENLEDVEDENVKLDNYNIDGSLNNADLSQEPITNDGENVDWEATSEDVLERGYESAFPESEGTINSSKRRLSVTTDTENIELSDELASAGTPKKSKLMPSDD
What is the function of this protein?
Required for normal levels of gene conversion events during meiosis.
What are the official names of this protein?
Reduced meiotic recombination protein C1442.04c.
What is the protein family that this protein belongs to?
Belongs to the RMR1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: KDSB_PSYCK
Sequence: MSSALMPVKTHIVIPARLKSTRLPNKPLLTIHGKPMILWVAEKARLADFADDMCIATDDESIAKICLDAGFDVVMTSSEHASGTDRLAEVAAIKGWAAHDIVVNMQGDEPLVPPLLLEQVKTLLVQDAESVMATLCEPIEDYDTFMRPSVVKVVSQTSNDQQRALYFSRAPIPCNRDVVLTSENSKQPPKNAYRHLGLYAYRVSLLQQFVHCSQTPLEILESLEQLRVLENGGHIAIAKAACSLPAGVDTQEDLDRLNAMSLTDFQDY
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_SYNJB
Sequence: MQLQEIAQKLGCAYEGDPTLEIHSVASLAEARPGELSFLSEARYLPLLEQTQASAVIVEEGLALPCSIACLRGRDPRLLFAQAIELFYQPYRLPVGIHPTAVIDPSVELGEGVAIGPHAVVMEGVKIGDHTQIHPNVTIYPHVRIGSRCQLFANCVIHERTEIGDDCLIHSGAVIGDDGFGHIPLADGSWRRMLQAGRVVLEDNVEVGSNTTIDRAAVGETRIGRGTKIDNLVQIGHGVRTGSHCLIVAQVGIAGSTQLGHHVILAGQCGLAGHLHIGDGVRVAAQTGVTSDVPAGQTVAGYPHQPIAEWRKSMAVQRHLPELQRTLRKLEARVAKLEQNSTDRAPNAKMLEVGVDPETTCSS
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: ADDB_STAAR
Sequence: MTLHAYLGRAGTGKSTKMLTEIKQKMKADPLGDPIILIAPTQSTFQLEQAFVNDPELNGSLRTEVLHFERLSHRIFQEVGSYSEQKLSKAATEMMIYNIVQEQQKYLKLYQSQAKYYGFSEKLTEQIQDFKKYAVTPEHLESFIADKNMQTRTKNKLEDIALIYREFEQRIQNEFITGEDALQYFIDCMPKSEWLKRADIYIDGFHNFSTIEYLIIKGLIKYAKSVTIILTTDGNHDQFSLFRKPSEVLRHIEEISNELNISIERQYFNQLYRFNNQDLKHLEQEFDALQINRVACQGHINILESATMREEINEIARRIIVDIRDKQLRYQDIAILYRDESYAYLFDSILPLYNIPYNIDTKRSMTHHPVMEMIRSLIEVIQSNWQINPMLRLLKTDVLTTSYLKSAYLVDLLENFVLERGIYGKRWLDDELFNVEHFSKMGRKAHKLTEDERNTFEQVVKLKKDVIDKILHFEKQMSQAATVKDFATAFYESMEYFELPNQLMTERDELDLNGNHEKAEEIDQIWNGLIQILDDLVLVFGDEPMSMERFLEVFDIGLEQLEFVMIPQTLDQVSIGTMDLAKVDNKQHVYLVGMNDGTMPQPVTASSLITDEEKKYFEQQANVELSPTSDILQMDEAFVCYVAMTRAKGNVTFSYSLMGSSGDDKEISPFLNQIQSLFNQLEITNIPQYHEVNPLSLMQHAKQTKITLFEALRAWLDDEIVADSWLDAYQVIRDSDHLSQGLDYLMSALTFDNETVKLGETLSKDLYGKEINASVSRFEGYQQCPFKHYASHGLKLNERTKYELQNFDLGDIFHSVLKYISERINGDFKQLDLKKIRQLTNEALEEILPKVQFNLLNSSAYYRYLSRRIGAIVETTLSALKYQGTYSKFMPKHFETSFRRKPRTNDELIAQTLTTTQGIPINIRGQIDRIDTYTKNDTSFVNIIDYKSSEGSATLDLTKVYYGMQMQMMTYMDIVLQNKQRLGLTDIVKPGGLLYFHVHEPRIKFKSWADIDEDKLEQDLIKKFKLSGLVNADQTVIDALDIRLEPKFTSDIVPVGLNKDGSLSKRGSQVADEATIYKFIQHNKENFIETASNIMDGHTEVAPLKYKQKLPCAFCSYQSVCHVDGMIDSKRYRTVDETINPIEAIQNININDEFGGEQ
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease AddB, DNA 3'-5' helicase AddB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 1 subfamily.