PharMolix/UniProtQA huggingface dataset:
Protein: ABDH_ECOLI
Sequence: MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA) (PubMed:3510672, PubMed:16023116).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal, which allows E. coli to grow on putrescine as the sole nitrogen source (PubMed:3510672, PubMed:22636776).  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate (PubMed:30498244).  Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency (PubMed:15381418, PubMed:16023116).
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: SURE_RHOP5
Sequence: MRILCTNDDGVHAPGLKIVEEIARALSDDVWVVAPELDQSGVSHSLSLNDPLRLREIGPRHFAVRGTPTDCVIMGARHILGDKGPDLVLSGVNKGRNVAEDVVYSGTIAGALEGTILGIPSFALSQEYSHDSRSAPLWETALAHGPKILRKALDAGVPKNTVINVNFPACAPEEVAGVLVTRQGKRNQGFLRVDERRDGRGNPYFWIGFERVVVVDTPAEGTDLAALAARYISVTPLKLDRTDEGFSEALRSTLA
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRC_DESRM
Sequence: MRYLIKGGIVVDPVADTLTCTDILVEEGMIKEIGQLSDSEAEVIAAEGNYVCPGFMDMHVHLREPGYEYKEDIVSGTRAAAMGGFTSVACMPNTNPVADNAAIISHVLAKARNAAARVFPIGALTKGSLGKELTEMADLKGAGAVALSDDGMPVMNADIMLRVMQYASMLEMTVISHCEDNKLSEGGQMHEGAVSAMLGLKGIPSLAEEIMVARDILLSEYTGCRLHLAHISTEGSVRLVRQAKERGVPVTAEATPHHFTLTEEAVQGYSTNAKVNPPLRRQTDVEAIKEGLRDGTIDVIATDHAPHAYHEKDVEFQYAPNGMIGLETAVGLIFTQLVQPGILTVPQAVAKLTCNPHRVLGLSGGRLLPGTPANITIIDPKLSEVVDPTKLLSKSKNTPFGRWKLTGLPVLTMKDGLLVMRDRQLLE
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: ATG4_GIBZE
Sequence: MERAMANVDLGPYRRIVQIFWDPEPTNDVVHDQPVWCLGRSYRLNGKKNIKADDHHPQTPPSVLKAETETQEAHDTAQPPNPPTNAPDTPPDSISSSFSSSLAYDDPVVDGGWPSGFISDFESKIWMTYRSEFEPIPRSTNPQATSALSLSMRLKSQLGDQSPFSSDSGWGCMIRSGQSMLANTIAMVRLGRGDWRRGESVEEECRLLKDFADDPRAPYSIHSFVRHGASACGKYPGEWFGPSATARCIQALTNSHESSIRVYSTGDGPDVYEDEFMQIAKPPGEDFHPTLVLVGTRLGIDKITPVYWEALIAALQMPQSESQGKYYQYITRTFSALTIRSGRPSSSHYFIGAQGSFLFYLDPHHTRVALPYHEDPIEYTSEEIASCHTPRLRRIHVREMDPSMLIGFLIQNEVDWQELKRNVKHVQGKSIIHITDRNAVLGGSSEGRESAIDEVETLSDDDTDTIHEA
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS (By similarity).  Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236).  Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
What are the official names of this protein?
Cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: RNH2_ACET2
Sequence: MGNMTVKQIEKSVEGLDLDKALEKLYCLKAEFGDRVDKIIEKYEKKKLKYEKELNRYLEMCIYEKEAYQRGYKLIAGIDEAGRGPLAGPVVAAAVILPQDVFIEGLNDSKKLTENQREKLFDVINDKAIGVGIGIVDEKQIDEINILNATKKAMKLAVGNLKPVPDILFIDSLKLDDINIEQNSIVKGDAKSVSIAAASIIAKVTRDRILREMDKKYPMYGFARHKGYGTGEHIEAIKKYGICPIHRVSFTKNFIV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y577_STACT
Sequence: MLHLHIFSWVIGIILFIVSYISFTKTGAPKKAYKPLHMTLRLFLVLILFSGVWQVVEEFATATGSTHMLLTLKMICGIGVVALMEVTLVRKQRGASHKGLFWGTIALIIVTMALGIILPGGPISNMFVITK
What are the official names of this protein?
UPF0344 protein Sca_0577.
What is the protein family that this protein belongs to?
Belongs to the UPF0344 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNPA_YERPN
Sequence: MVKLAFPRELRLLTPSHFTFVFQQPQRAGTPQITILGRLNELGHPRIGLTVAKKHVKRAHERNRIKRLTRESFRLHQHALPSMDFVVLVKKGVADLDNRALTEALEKLWRRHCRQAPAS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RL27_HERAR
Sequence: MAHKKGGGTTRNGRDSESKRLGVKVYGGQVINAGGIIIRQRGTKVHPGENVGMGKDHTLFALTDGKVAFVIKGALQRQYVTVVPA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: CRU1_ARATH
Sequence: MARVSSLLSFCLTLLILFHGYAAQQGQQGQQFPNECQLDQLNALEPSHVLKSEAGRIEVWDHHAPQLRCSGVSFARYIIESKGLYLPSFFNTAKLSFVAKGRGLMGKVIPGCAETFQDSSEFQPRFEGQGQSQRFRDMHQKVEHIRSGDTIATTPGVAQWFYNDGQEPLVIVSVFDLASHQNQLDRNPRPFYLAGNNPQGQVWLQGREQQPQKNIFNGFGPEVIAQALKIDLQTAQQLQNQDDNRGNIVRVQGPFGVIRPPLRGQRPQEEEEEEGRHGRHGNGLEETICSARCTDNLDDPSRADVYKPQLGYISTLNSYDLPILRFIRLSALRGSIRQNAMVLPQWNANANAILYVTDGEAQIQIVNDNGNRVFDGQVSQGQLIAVPQGFSVVKRATSNRFQWVEFKTNANAQINTLAGRTSVLRGLPLEVITNGFQISPEEARRVKFNTLETTLTHSSGPASYGRPRVAAA
What is the function of this protein?
Seed storage protein.
What are the official names of this protein?
12S seed storage protein CRA1, Cruciferin 1, AtCRU1, Cruciferin A1, Legumin-type globulin storage protein CRA1.
What is the protein family that this protein belongs to?
Belongs to the 11S seed storage protein (globulins) family.
What are the subcellular locations of this protein?
Protein storage vacuole.
Protein: YB2G_SCHPO
Sequence: MSDSFFKDIPEFLETRVNESLDARSKSIAQFKELGPPDQVNTIKVNAKNPSKEVGTYHFVSGVDASSSASLAAYLNTLSYSLDKSQQWFGKGNAWRVSHGVYCCYNVFSQVDVRVEAKIPGGVDTYAIDENGQKHIVDARMWTEAYMSEVLRSLLYSDDTNSRFAGHRRFNPIPNPDAELRFFEAAEQLFTLGYTLGSSSEVRVPTHVNNHLVRGIFAYLKQTCRYSAALNLFEKLRVSIPEVSVLLAELYLLMDHEVHAVRILHDSLLKQRMSASLLIVQVKFLISKERYDLALICAKRAVHASPSEFATWACLADVYLHLEDFKSALLALNSCPMYTYYERDAYPLPPSARAHLPFPVNFPKEELEVENNAQNGYTVSTEITDPYLARLPSPSLRGTFAKAYEMLTLICAKIGWDELLRVRSAVFVMEEEYRSLNDITEGNASPDQNEVAEESVAEEVVGLDKPETSVGSLPKNATVQSKRLCERWLDNLFMVLYEDLRVFTIWRAEYTHFKSQGLAYRKAPAEWEILGEVAFRLHHRVEAVEAFCACLESMFSFKAWKTLLIIYSEDNNIELVLTAIAKLTLYNYRWYQEYSPFLLEQMKNRIMQDGALKMKSILASTRLDPYILNLIHKLYFEWAIAFQIPGHEL
What are the official names of this protein?
Uncharacterized protein C31F10.16.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: GLK_HELPS
Sequence: MPKTETYPRLLADIGGTNARFGLEVAPRQIECIEVLPCKDFESLSDAVRFYLSKCKESLKLHPIYGSFAVATPIMGDFVQMTNNHWTFSIETTRQCLDLKKLLVINDFVAQAYAISAMQENDLAQIGGIKCEINAPKAILGPGTGLGVSTLIQNSDGSLKVLPGEGGHVSFAPFDDLEILVWQYARSKFNHVSAERFLSGSGLVLIYEALSKRKGLEKVAKLSKAELTPQIISERALNGDYPICRLTLDTFCSMLGTLAADVALTLGARGGVYLCGGIIPRFIDYFKTSPFRARFETKGRMGAFLASIPVHVVLKKTPGLDGAGIALENYLLHDKI
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPB_YERPE
Sequence: MTTLNPYFGEFGGMYVPQILVPALKQLEDAFVSAQLDPEFQAAFQDLLKNYAGRPTALTLCQNLTKGTKTKLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTEIIAETGAGQHGVASALACALLGLKCRIYMGAKDIERQSPNVFRMRLMGAEVIPVHSGSSTLKDACNEALRDWSGTYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILEKEGRLPDAVLACVGGGSNAIGMFADFIDEPDVGLIGVEPAGLGIETGQHGAPLKHGKVGIYFGMKSPMMQTSDGQIEESYSISAGLDFPSVGPQHAYLNSIGRADYVSITDDEALDAFKTLSCKEGIIPALESSHALAHALKMIKADPDKEQILVVNLSGRGDKDIFTVHDILKARGEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: ARL_SCHPO
Sequence: MGLLTILRQQKLKEREVRVLLLGLDNAGKTTILKCLLNEDVNEVSPTFGFQIRTLEVEGLRFTIWDIGGQKTLRNFWKNYFESTEAIIWVVDSLDDLRLEECRNTLQELLVEEKLLFTSILVLANKSDVSGALSSEEISKILNISKYKSSHWRIFSVSALTGLNIKDAISWLANDLKEIKLGTIDY
What is the function of this protein?
Has a role in the cofactor-dependent pathway of microtubule biogenesis.  Required for growth polarity control.
What are the official names of this protein?
ADP-ribosylation factor-like protein alp41, Altered polarity protein 41.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ZFP92_MOUSE
Sequence: MAATLLRAKPKVTVSFEDVSVYFTKTEWRLLDLKQRTLYKQVMLENYSHLVSVGFAFSKPNLVSQLERGEKPWIRDDGMESAARSCAGNRIKTKTLTSKPKLFGRGLLRNTSRSSLQRRPHDFRPNPIVRYQHSRIADKRYLCQQCGKSFSRSFNLIKHRIIHSREKPYECSECGKQFQRSLALLEHQRIHSGDKPYECGECGKTFTRSSNLVKHQVIHSSEMPFVCRMCGKVFRRSFALLEHTRIHSGERPFECTECGKAFSRSSNLIEHQRIHSGQKPYICKECGKAFKGVSQLIHHQLIHRGDKPFTCHEYGKAFRGLSGLSQHQRVHRGEKPYECSECGRAFGRRANLFKHQVVHGGVRLQHRTRGKGFQRKLLEHLRDLHGQQPQEAGEGSSAEPQPIDTNEKPQVCERCGQVFENKLLLCRHLRIHDDEDDKKQKPVISSTSVLEDKSLLSQHLEAQPTEESDSEGSVVFVYAEKPHGPSSP
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 92, Zfp-92.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COAX_COLP3
Sequence: MILLIDIGNSRTKYVQLISGELSATTQLNNSEFSAEYFTKYFNQASQLIVANVAKSALTDELATWCAREKISYKQVHSEQKKNTLISAYQEPTTLGIDRWLALLGTIHLYPQENVLIIDAGTATTVDLLTSNGQHQGGWILAGINALFTSILSHSTLVHAKSKTMPSLAFGANTSDNVNNACWAATLGMIERAIEQAQQLGDINRIILTGGDGKALTRLLLAQTTENILAVENIQFIDNLIFFGLQEYA
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_RHIL3
Sequence: MELNGLRVSRETQERLQHFAALFQKWAKAINLVAPSTLDDLWHRHIADSSQVFQIHPQPITWVDLGSGGGFPGVITAIFLAELQGGWVHLVESNHKKAAFLRTALRETNARGSVHSIRIEDAYTEVRECSAISARALTDLDGLIGYSSPWMLGKENCRGFFHKGRDYLREIDKARGRWEFDLLEHKSAVEQESVILEISNLRRLV
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_LAWIP
Sequence: MISVIGIDPGSRNTGWGIVHEVSGVLHLVCCGVIQPSCNGSFAERLAHIFQEISSIIMKYKPVEASVEQVFTAQNPLTALKLGQARGAAVVACANQGLLIKDYEATTIKKTLVGHGRATKEQVSFMVGRSLGVKPDWPIDTSDALATAICHLTIRRFENRTARVAKTL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: CMOB_PHOLL
Sequence: MIDFGNFYQLIAKNNLQHWLNCLPAQLQEWQKAALHGNFKSWVKTLENLPEISPTQLDLKNGVIAERDPPLSAGEKICLTNILRIFMPWRKGPFSLYGINIDTEWRSDWKWDRVLPHISPLTGRTILDVGCGSGYHLWRMVGEGAELAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALAAFDTVFSMGVLYHRRSPLDHLWQLKNQLISDGELILESLVVEGDEHTCLIPGERYAQMRNVYFIPSAKMVKIWLEKCGFVDVKIVDQAVTATEEQRRTDWMKTESLSDFLDPTDSNKTIEGYPAPLRAILIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: RBTN2_XENTR
Sequence: MSSAIERKSLDPTDEPVDEVLQIPPSLLTCGGCQQSIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAFEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKLNEMM
What is the function of this protein?
Transcription factor that acts synergistically with tal1/scl and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate.  Induces globin gene expression together with fgf (By similarity).
What are the official names of this protein?
Rhombotin-2, LIM domain only protein 2, LMO-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: MINY1_RAT
Sequence: MEQPQAECPAPSKTNSAETVESEKHEALSGPEKHPQDKDGADAAPEKHPQDKDGADAHGEAGKQKSGDQTLPPVQDGGNLECPPPEASSSPPGPACGIPSEVETTEACSRPQQLPQSPRIQQPDLDFYCVKWIPWKGERTPIITQSSNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELLTHLGNCLLSIKPQEKSEGLQLNFQQNVGDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGVPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKIIICKHSSDSNLVTEGLIAEQFLETTAAQLTYHGLCELTATAKEDELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKSHGAEGGSGSPEKQLQVDQDYLIALSLQQQQQPQGMLGLSDLELAQQLQQEEYQQQQAVQPVRTRAPSSPGRGATSGRPAGERRQRSKTESDCVLL
What is the function of this protein?
Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins.  Has exodeubiquitinase activity and has a preference for long polyubiquitin chains.  May play a regulatory role at the level of protein turnover.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase MINDY-1, Deubiquitinating enzyme MINDY-1, Protein FAM63A.
What is the protein family that this protein belongs to?
Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
Protein: BIOB_PSET1
Sequence: MELAPVRHNWTHSEVKAIFEMPFNDLLFKAASVHRANFNPNEVQISTLLSIKTGACPEDCKYCPQSGHYRTDLERERLIEVEKVVEQARLAKQKGATRFCMGAAWSDPKDRDMPYISQMVKEVKELGLETCMTLGMLNNEKAHELRNAGLDYYNHNLDTSPEYYEQIISTRTFQDRLDTIGNVRDAGMKVCSGGIVGMGEQAADRYGLLMQLANLDQQPESVPINMLVKVKGTPLENVDDLDHFEFIRTIATARIMMPHSYVRLSAGRNAMNEQMQSMCFFAGANSIFYGDKLLTTENPDADADMALIKKLGMNPETRHDYSDEAVAASLSSQVADKATSKLFYEA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: CHBG_SALPC
Sequence: MERVLIVNADDFGLSKGQNYGIVEAYRNGVVTSTTALVNGEAIDHAAQLSRELPALGVGMHFVLTLGKPVSEMPGLTRDGLLGKWIWQMAEEDTLPLDEIAHELACQYQRFIDVFGREPTHLDSHHHVHMFPQIFPIVARFAAQRGIALRIDRQTVLNADDLPSDLRSTQGFSSEFYGEEITEACFLRILDASTHRGEASLEVMCHPAFVDNIIRQSAYCYPRLTELEVLTSASLKAAIAERGYRPGSFLDI
What is the function of this protein?
Involved in the degradation of chitin.  ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose.  Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF.  Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF.
What are the official names of this protein?
Chitooligosaccharide deacetylase, COD, Chitin disaccharide deacetylase, Chitobiose deacetylase, Chitobiose-6P deacetylase, Chitotriose deacetylase, Chitotriose-6P deacetylase.
What is the protein family that this protein belongs to?
Belongs to the YdjC deacetylase family. ChbG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_STRGC
Sequence: MSRILDNEQMMDEEMVERTLRPQYLQEYIGQDKVKNQLKIFIEAAKLRDEALDHALLFGPPGLGKTTMAFVIANELGVNIKQTSGPVIEKAGDLVAILNDLEPGDVLFIDEIHRLPMAVEEVLYSAMEDFYIDIMIGSGDANRSVHLDLPPFTLIGATTRAGMLSNPLRARFGITGHMEYYEEADLTEIVERTAEIFEMDITHEAAKELALRSRGTPRIANRLLKRVRDYAQIMGNGLIDETITDQALSMLDVDHEGLDYVDQKILRTMIEMYGGGPVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRTGRVATRKAYEHLGYEYMEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: COX1_RICBR
Sequence: MDITTNDLNHDDHHTPHGWKRWLFSTNHKDIGIMYIIFAIFAGIVGGLFSLLFRLELAMPGGTFLNHDFQLYNVLITAHAVIMVFFMIMPALFGGFGNYFVPLLIGAPDMAFPRLNNISFWLLVPAFILLMGSAFVDGGPGTGWTLYPPLSSISGHPGAAVDMAIFSLHLTGLSSILGSINLIVTIFNMRAPGMGLFKMPLFVWSILVTAFLIILAMPVLGGAITMLLTDRNFGTTFFKTDGGGDPVLFQHLFWFFGHPEVYIVILPGFGIVSQVISTFSRKPIFGYQGMVGAMVIIGFVGFIVWAHHMFTVGLSYNALIYFTAGTMIIAIPTGIKIFSWIATMWGGSITFPTPMLFSIGFIILFTIGGVTGIILSNSALDRVLHDTYYVVAHFHYTMSLGALFTAFAGFYYWFGKISGKQYPEILGKIHFWITFVGVNLTFFPQHFLGLAGMPRRIPDYPEAFAGWNMVSSIGAGISMAAALYFVFIVFYTLKYGKDCPNNPWGDGADTLEWTLTSPPPFHTFETPPHIEE
What is the function of this protein?
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Subunits 1-3 form the functional core of the enzyme complex.  CO I is the catalytic subunit of the enzyme.  Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
What are the official names of this protein?
Probable cytochrome c oxidase subunit 1, Cytochrome aa3 subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS18_LACH4
Sequence: MAQQRRGGRRRKVDYIAANHIDYVDYKDVDLLKRFISERGKILPRRVTGTSAKNQRKVANAIKRARIMGLLPFVAED
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: CID10_ARATH
Sequence: MAVAENAGVKVDSSGQNLDNNNTAASATETTKPPCPDDDQSPKSDSSTPLTIDSTPETDDRINETAQKVQTLNGFSGNGERDNNGEIKDLADAFSKLNPMAQEFVPPSLARSQSGVLRNGLGFTNNFAAPPKLADGNDHFPRRRRSFGQGKRRMNKRTSLAQKDDVIRRTVYVSDIDQQVTEENLAGVFINCGQVVDCRVCGDPNSVLRFAFIEFTNEEGARAALSMSGTVLGFYPLKVLPSKTAIAPVNPTFLPRSEDEREMCVRTVYCTNIDKRITQIDLKGFFEMLCGEVHRLRLGDYHHQTRIAFVEFAMAESAIAALHCSGIVLGALPIRVSPSKTPVRPHFPRAEFK
What are the official names of this protein?
Polyadenylate-binding protein-interacting protein 10, PABP-interacting protein 10, Poly(A)-binding protein-interacting protein 10, PAM2-containing protein CID10, Protein CTC-INTERACTING DOMAIN 10.
What are the subcellular locations of this protein?
Nucleus.