PharMolix/UniProtQA huggingface dataset:
Protein: 3SA4N_NAJAT
Sequence: MKTLLLTLVVVTIVCLDLGYTRKCNKLVPLFYKTCPAGKNLCYKMFMVSNLTVPVKRGCIDVCPKSSLLVKYVCCNTDRCN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pore in lipid membranes.  In vivo, increases heart rate or kills the animal by cardiac arrest.  In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
What are the official names of this protein?
Cytotoxin 4N, Cardiotoxin-4N, CTX-4N.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: SYV_NITOC
Sequence: MDKNYNPQAIEQYWYQIWEQKGYFTPQGKDSSYCIMIPPPNVTGHLHMGHAFQSTIMDALIRYHRMRGDDTLWQVGADHAGIATQMVVENQLNAEGKTRHDLGREAFIQRVWEWKEHSGGTITRQLRRMGTSVDWSRERFTMDEGLSQAVGEVFVRLYDEGLLYRGKRLVNWDSVLHTAISDLEVISEEENSHLWHMRYPLSDGSGHLVVATTRPETMLGDTAVAVHPEDPRYQHLIGKTVALPLTDRTIPVIADDYVEPEFGSGCVKITPAHDFNDYEVGQRHGLPFINIFTVDASLNENVPERYRNLDRFEARKLVVADLEAAGLLEKIEDHKLMVPRGDRSRTVIEPYLTDQWFVKTAPLAEPAIQAVENGQIRFIPENWNKIYFEWMRNIQDWCISRQIWWGHRIPAWYDPEGKIYVAPTETQARQKYNLPPDLPLEQDPDVLDTWFSSALWPFSTLGWPEDTSLLRAFYPTSVLVTGFDIIFFWVARMIMMGLKFTGEVPFHEVYIHGLVRDAEGQKMSKSKGNVLDPLDLIDGIDLETLVTKRTGGLMQPAMAKRIEKATRKEFPQGIPSFGCDALRFTFAILATRGRDIRFDLGRIEGYRNFCNKLWNAARYVLINVSSEISVERQGKPEQAEENLMLGAPERWIISRFHSTTQEVIEGIENYRFDRVAQAIYNFTWNEYCDWYLELSKPVLNNPASPEAAKRRTRHTLVHVLEALLRLAHPIIPFITEEIWQQVGPLAGRQGKTIMLQPYPQPEIDKIDEDAVAEIEWVIAFVTGVRSIRSQMNIAPGKPIPLLLQAGKAHDRTRLESNQKFLAALAKLDSIQWLKDETPPPAATALVDELKLLIPLAGLIDKEAELKRLDREMQRMRKDLARVQGKLANSNYVERAPAEIVAKERQRAQEVTAALSTLEQQHAEITDLNP
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3110_CHESB
Sequence: MLYWALVFLVVAIIAGALGFGGIAGASAGIAQILFYIFLILLVVSLLFGLFRRAR
What are the official names of this protein?
UPF0391 membrane protein Meso_3110.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HSLO_ECO27
Sequence: MPQHDQLHRYLFENFAVRGELVTVSETLQQILENHDYPQPVKNVLAELLVATSLLTATLKFDGDITVQLQGDGPMNLAVINGNNNQQMRGVARVQGEIPENADLKTLVGNGYVVITITPSEGERYQGVVGLEGDTLAACLEDYFMRSEQLPTRLFIRTGDVDGKPAAGGMLLQVMPAQNAQQDDFDHLATLTETIKTEELLTLPANEVLWRLYHEEEVTVYDPQDVEFKCTCSRERCADALKTLPDEEVDSILAEDGEIDMHCDYCGNHYLFNAMDIAEIRNNASPADPQVH
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP5D_CHLPS
Sequence: MKTLAFCSFKGGTGKTTLSLNIGSNLAQVSRKKVLLVDLDPQANLTTGLGVQIQDDHSLNEILRHSNEIRRAIHKTKIENLDIIPSSVLVEDFRGLDKDISLSVNHLHLALQKVQDQYDVCILDTPPSLGILSQEAFLASDYLVVCLTPEPFSILGLQKIKEFCSTIGNNLDILGIVFSFWDERNSTNSTYMDIIETIYEGKILSSKIRRDVTVSRSLLKESSVINAYPNSRAAKDILNLTKEIENKLFSDEKLVQETL
What are the official names of this protein?
Virulence plasmid ParA family protein pGP5-D.
What is the protein family that this protein belongs to?
Belongs to the ParA family.
Protein: SCO1_MOUSE
Sequence: MAALVRAAVVRSQCRQLWRLFPRGHGLRDVAERPRPEEACSCLRSRAFSAGPPPPGAGPEPKGGQAGSHRPKPGPVSWKSLALTFAIGGSLLAGMKYFKKEKIEKLEKQRHRSIGKPLLGGPFSLTTHNGEPKTDKDYLGQWVLIYFGFTHCPDICPEELEKMIEVVEEIDSIPSLPNLTPLFITIDPERDTKEAIATYVKEFSPKLVGLTGTKEEIDGVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKKKAEIAGSIAAHMRSHMKKR
What is the function of this protein?
Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2).  Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation.  Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (By similarity).  Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (PubMed:25683716, PubMed:28973536).
What are the official names of this protein?
Protein SCO1 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the SCO1/2 family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane; Single- pass membrane protein.
Protein: RTC5_CANGA
Sequence: MGQTASSPQDNKESKSHPQFKTRDEILQYFNTRVVKLFTVTEIAAFKKRFNAIDLNEPIDDTLIKEALYLDAQPNVWSAVSETIRLLQNFPLFHQPIADSITGFGLLKVIAIINVKRFEKLVNTTITRYDITVTLGLCGQAKESENKIKSTNLGDILKTYDHIEIESIHIPYDKLILLVAWLLTLVTGVATTNCKVELSDTIANWNNFKSSAISIANTISTSALGNANDIGIPATDILNAFNTIMISLVPYMSNLFEHLLFGVDDLIDHVNDLANLSHQDVLTPSLYAQVIIGLPNSITITKLQKLYVGKESGFSMRSLQSKVFRWKAPTLMIVSGTRISDDESYADSKNPRYRSFLYSFPKLRENDQNLDAIHLTKKKVTYAVYIDEPWKVSNKEKFGATNMTIMELTPQQKTYQSCMERTMYFNTIGGGIGVGSEQPIVKQNDIKFIPGNISLTMDSSLEFGVFRHVGAGGGFKTSLLDNDDSKSFEIRFIIQNVEVWGCGGEKELAEQLKQLEWEEAEAKRRQTINLQSLSEDKALLEMVGLVGQHQSGGSV
What is the function of this protein?
May be involved in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 5.
What is the protein family that this protein belongs to?
Belongs to the RTC5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP71_PUCGR
Sequence: MTKAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTDTERLIGDSAKNQVAMNPHNTVFDAKRLIGRKFADAEVQSDIKHFPFTVFDKGGKPYIRVQYRGEDKEFSPEEISSMILTKMKEVAESYLGGTVTSAVVTVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKTVGERNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFKRKHKKDLSSNPRALRRLRTACERAKRTLSSAAQTTIEIDSLFEGVDFYTSLTRARFEELCQDLFRSTLEPVEKVLRDAKIDKAAVHEIVLVGGSTRIPRIVKLVSDFFNGKEPNKSINPDEAVAYGAAVQAAILTGDTSEKTQDLLLLDVSPLSLGIETAGGVMTPLIKRNTTVPTKKSEIFSTYSDNQPGVLIQVYEGERARTKDNNLLGKFELAGIPPAPRGVPQIEVTFDIDANGILNVSASDKTTGKSNRITITNDKGRLSKEEIERMVNEAEKYKAEDEEATARITSRNALESYAYNLRNSLTDEKLADKFDAADKKKLEDAVNSTISWLDNSQEASKEEYEEHQKELEAVANPIMQKLYAGAGGAPGGAPGGFPGGAPGGFPGGAPAGEDGPSVEEVD
What are the official names of this protein?
Heat shock protein HSS1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_ALIB4
Sequence: MFENDTIVAIATANGIGSISIVRVSGAKALEIATKISKKNNFKARLATLSTIYDSKNEIIDEALVIYFKSPFSFTGEDVVEFQCHGGVAISNMIVDEVLNAGARLANPGEFSKRAFFNNKIDLTKAEAISKIIEARSADAVKLLARQLKGELTNFVDEIREDLLFMLAYTEVSIDYAEEDLPTDIYEQIENKMQKISLKLSNTLEASRRREGMIEGFKVAIIGKPNVGKSSLLNKLLNFDRAIISDIAGTTRDTIEESVRIGTHIIKIVDTAGIRDASDVIEKIGIEKSIQAINEADIVIALFDNSKICDDEDKKILDLIKENSDKKVIVVLNKSDLQNQFDKNVLDSFIELSTKEDINPLIKELELILDSNTFGDDITLVSKRQVLAVENTLYNIGLAKEPLKSGELEFFAHFITQALEDISSITRPYDNDEMLDVMFGEFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COG7_DICDI
Sequence: MINNELKDIFSSNDFNSKTWINNLLSDCGGSGSSSGNAKSNQQSILTDQNNIKAELEIENICSNYLSKLQLYQIELNISLESITSESLLIVPKSIREVDRIRKESLHLKNRIKSISSKIGEMNNDSPQSMETVSVIEKLDQVKSRMEISIRSLKEAEKLLSFSKTVDQLFSSNDYLMISDKLEEVKQSLSVLSDVPEFREQSKKFNVYQDRLESQLKQPLQQSLQQKDLESCKNYLKIFTNIQRQDKFFIYYYQVRIDPLKLLWNSYSSSSSSSSSSSNFHNWLSKFYDEVLVMINSEFNWLSGLCPIDYIQVLENLIIHLFTTINPNVQSRIDQAITIANQTTQQPIKVNELLSIYKTTCSFLKSLSPIFPNIINSSSTPTTSPAVDKLFKVIFEPYKYFQNKFSEYEIKSVKSQLQSISPILTLQKKSGGGSGGSGNADFTNIIKNIENQFIPKSFQIAQQSIERFFDFTHTTDIDSYVNTVLNQIFTEISLILRDTINELKFITGLTTNYIIGSSGTFPNFNQQQQQINTPSSINGEVDPVKKLTNSHTRSHSRSGSGSGNSNSNSVGTSATLQNWEYFQGAMNLLQSIHQLLNKFQQFDNSTSLNIIHYLGNSNNSNNSSSNNDNDQFICNIRKFLLGKDLNKIQKLQISVQNLENIISSPLPLSSSSSVSKDQSISKKPLLLQESFNQISKLLSISQHFVYETLIYFIKLKLKELPKIVSNEWNNNNNNNNNPSQNNGGGGGGGLSYISQITDHLLTIPQQLDPYSEEELTRFSLSTSLQYPIKTCSNSEDDFYQNLLIQYQREKQFDDEQLLIEKLKEKQEQQQEQQEKEQQQEKEQQDADQDININTNNNNENDENDEDDELEDGIAHQWITIVAKATEKLYLQTIVEIITLNEPSCQQLSNDIGYLFNVLSALGVSAEPLLQKTQSLLEMNRDTFTSFYHQQLHNNNNNNNNNNGNSNNNNNNTNNISLLTNAEKNICNLIGKMRNIK
What is the function of this protein?
Required for normal Golgi function.
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 7, COG complex subunit 7, Component of oligomeric Golgi complex 7.
What is the protein family that this protein belongs to?
Belongs to the COG7 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein.
Protein: CAF17_DANRE
Sequence: MQRMILFGGALREIVVRSGGLQAHYFLCTSRTRIKTHSQTRAASSTAHFSCYRLPHRTVLNVSGQDTSSFLQGIITNDMNLLGEDSLNAMYAHVLNVQGRTLYDIILYSLKGNPDGLNGVLLECDSTVQDSVMQLLKVYKIRRKVNLSVCPSLSLWALLPHSKEAVLGRPDVTTTDKVLVLEKDPRTELMGWRMITSAQDNPLDIVSACRLGNTEEYHRHRYEIGLPEGVGDLPPGEALPLEANLVYMQGISFSKGCYIGQELTARTHHTGVIRKRLMPVSLSAPAEKLNQGSALQTEGGKPAGKYRTGVDKLGLSLVRLAHAKETLQLKSSGDETVTVLASVPDWWPKTPQEK
What is the function of this protein?
Required for normal heme biosynthesis.
What are the official names of this protein?
Putative transferase CAF17 homolog, mitochondrial, Iron-sulfur cluster assembly factor homolog.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RLUC_RICBR
Sequence: MIITVNSPIASRLDKYLRRLYPLLTQGVIEKALRQKQIIVNSKKAEASLRVVEGDEIFIHDKFNLPIAQPTKLVFTDAEITLAKKITTEYLIYEDDNIIAINKPAGLATQGGSKINLSVDSALKYLNSQGADFKLVHRLDKETSGLLLIAKNYVSSVKLHDAFKEKLVEKTYLAVTYGKPIKDQGEVKTNIEKSKGSIPKITDINDNNGKLAITYYKLLKSLTNNLFLVEFIPITGRMHQLRLHAKLLGCPIFGDNKYGNDKLMPYSKYMFLHANNIVLSKKVFGKEVNLEAKLPSYFNRV
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase C, 23S rRNA pseudouridine(955/2504/2580) synthase, rRNA pseudouridylate synthase C, rRNA-uridine isomerase C.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: GP17_BPPZA
Sequence: MNNYQLTINEVIEIINRNTDINKLVAKKDNLYPTDLYDLDKQQLIAIILNSDFALSSIKRALLEVTVEELGEQDNDDDLDEIDSELYEDAEASDVPHETIVKVFEADKSIVTFNGEKLKHYVNVDVDNSSVDEVKKIAKEISEHDFNDEDIEEAELKTFKNHLPTIYSMKKENK
What is the function of this protein?
Involved in the replication of viral DNA.  It is required at the very beginning of the virus amplification, conditions in which a low number of viral DNA molecules enter the host cell, possibly to recruit the limiting amount of initiation factors at the replication origins.  Once the infection process is established and the other replication proteins reach optimal concentration, it becomes dispensable.  Optimizes the binding of protein p6 at the viral DNA ends, thus favoring the initiation of replication.
What are the official names of this protein?
DNA replication protein 17, Gene product 17, gp17, Protein p17.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus protein p56 family.
Protein: ASPA_PROMM
Sequence: MSGLQVLLVAGTHGNEINGPWLLDQWSQTPELINTHGVGVVPVIGNPEALALGRRYLDCDLNRSFRLDLLRSPSILDREVVRAKQLLSFFGPEGSTPCQIVIDLHSTTSAMGSTLVVYGRRSVDLALAALIQARLGLPIYLHDGDDDQQGFLVERWPCGLVIEIGPVPQGLLKARIIEQTRLAVQACLEALSSVASGSPTYPDEFVVHSHLGSLDLPRDALGQPAACVHPSLQGRDWQPLQMGAPLFLWPDGEVFRFEGRDSPIPVFINEAAYVEKHIAMSLTCREVCPLPEQWQGALQQLVDC
What are the official names of this protein?
Probable aspartoacylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Protein: CINAL_PROM2
Sequence: MSPNSKGVEILSIGTELLLGNITNTNAQWISEQLSQLGLNHFRQSTVGDNRDRIIKVIQEISQRSNLLITTGGLGPTPDDLTTEAIATSFNVSLFERPHLWDEIKQKTSNSKLQDNSSSLRKQCFFPKNAQIINNPRGTAPGMIWEPIKGFTILTFPGVPSEMKTMWKETAFDFIKTKFSDSYSFFSKTLKFSGIGESSVAEKINDLLNLKNPTVAPYANLGEVKLRITARAKNEVEAKNIIKPVKEKLKKKFPKFIFGEDNDTLPSVLIKELAKRNETIVFAESCTGGLLSSSITSISGSSQVFQGSIVSYSNELKNSLLNISEDNLKKYGAVSEEVCEAMAINIKNRLGADWAIGVSGIAGPNGGSQEKPVGLVYISIAGPNNHITNIKKKYNSTRNRIEIQTLSVNVCLNSLRLILLSNSK
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: FLIH_BUCAI
Sequence: MSNLILEKKWTKWYPENISFKNTKKIKKILCSSNNFKKEDFFIDKKNQKDLTFSKETSEINLTQKKAYETGFQTGLLKGKEENTLLKNKLNDLFLNFENSLAKFENELCSQLLKTVLKISSYVIGKKIDIDKQILLNYIKKIINKEGVFLKKPQFIIHPKNKTLIEDIFKKFLNSHKWTIVCDDGIDLNGCKIKSESVDIDATVDARWQQLCRLIYLEEY
What is the function of this protein?
Needed for flagellar regrowth and assembly.
What are the official names of this protein?
Flagellar assembly protein FliH.
What is the protein family that this protein belongs to?
Belongs to the FliH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBI_ORYSA
Sequence: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGRDE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: URE1_MYCTO
Sequence: MARLSRERYAQLYGPTTGDRIRLADTNLLVEVTEDRCGGPGLAGDEAVFGGGKVLRESMGQGRASRADGAPDTVITGAVIIDYWGIIKADIGIRDGRIVGIGKAGNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCHVHLICPQIIVEALAAGTTTIIGGGTGPAEGTKATTVTPGEWHLARMLESLDGWPVNFALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSTPAAIDTCLAVADVAGVQVALHSDTLNETGFVEDTIGAIAGRSIHAYHTEGAGGGHAPDIITVAAQPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIPEDLAFAESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVMKARRGALEGDPSGSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGKLADLVLWEPAFFGVRPHVVLKGGAIAWAAMGDANASIPTPQPVLPRPMFGAAAATAAATSVHFVAPQSIDARLADRLAVNRGLAPVADVRAVGKTDLPLNDALPSIEVDPDTFTVRIDGQVWQPQPAAELPMTQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDH11_MOUSE
Sequence: MFGFLLLLSLPFILYLVTPKIRKMLSSGVCTSNVQLPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELAAREIQAVTGNSQVFVRKLDLADTKSIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNLSSLGHHLGRIHFHNLQGEKFYSAGLAYCHSKLANILFTKELAKRLKGSGVTTYSVHPGTVHSELTRYSSIMRWLWQLFFVFIKTPQEGAQTSLYCALTEGLESLSGSHFSDCQLAWVSYQGRNEIIARRLWDVSCDLLGLPVDW
What is the function of this protein?
Retinol dehydrogenase with a clear preference for NADP (PubMed:12807874, PubMed:29567832).  Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (By similarity) (PubMed:12807874).  Exhibits also reductive activity towards toxic lipid peroxidation products such as medium-chain aldehydes trans-2-nonenal, nonanal, and cis-6-nonenal (PubMed:12807874).  Has no dehydrogenase activity towards steroid (PubMed:12807874).  Seems to be required for homeostasis of retinol in liver and testis (PubMed:29567832).
What are the official names of this protein?
Retinol dehydrogenase 11, Androgen-regulated short-chain dehydrogenase/reductase 1, Cell line MC/9.IL4-derived protein 1, M42C60, Prostate short-chain dehydrogenase/reductase 1, Retinal reductase 1, RalR1, Short-chain aldehyde dehydrogenase, SCALD.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: ARGR_STAAS
Sequence: MPKKSVRHIKIREIISNEQIETQDELVKRLNDYDLNVTQATVSRDIKELQLIKVPIPSGQYVYSLPNDRKFHPLEKLGRYLMDSFVNIDGTDNLLVLKTLPGNAQSIGAILDQINWEEVLGTICGDDTCLIICRSKEASDEIKSRIFNLL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: D19L3_MOUSE
Sequence: MMYIRQRKETKPIEVSEDFPSPKEDVKLEKKLPSGCASGRFWKILSSAVGGTVALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRTINLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLPAMKATWLYGIQISCLLLVCTLQFFNSMILGSLLISFNLSVLIVRKLQKNLKTGSFLTRIWKLLLHLLLVFCLTLFLNNIIKKVLNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFVLVVTVVTASVVAFHNLSDSTSLKSMDQTRKRAVDLKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFGLCSSEVWELLLRLVHLCNPKRIWVLRYLVPVLTLLYLCYKSWPGVMDELSELKEFYDPDTVELMTWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRHHRGCRLRDLLDVANGHEMDGPGESDPDLRPADHPRFCEEIKRNLPSYAAHFTRVFQNKTFHVYKLSRNK
What is the function of this protein?
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
What are the official names of this protein?
Probable C-mannosyltransferase DPY19L3, Dpy-19-like protein 3, Protein dpy-19 homolog 3.
What is the protein family that this protein belongs to?
Belongs to the dpy-19 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ASSY_STAA1
Sequence: MKEKIVLAYSGGLDTSVAVQWLIDKGYDVVACCLDVGEGKDLDIVYKKALDMGAVECHIIDATKEFSDEYVSYAIKGNLMYENAYPLVSALSRPLIAKKLVEIAEKTNSVGIAHGCTGKGNDQVRFEVAIKALNPSLKAFAPVREWAWSREEEIDYAIKHNIPVSINHDSPYSIDQNLWGRANECGILEDPYAAPPEDAFDLTNALEETPDTADEIILTFDKGIPVQIDGKTYELDDLILTLNALAGKHGIGRIDHVENRLVGIKSREIYEAPAAEVILKAHKALETITLTKDVAHFKPIIEKQFAEQLYNGLWFSPLTDSLKLFIDSTQQYVSGDVRIKLFKGNAIVNGRKSPYTLYDEKLATYTKEDAFNQDAAVGFIDIYGLPTQVNAMLHGGYSNEQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPE_BPPM2
Sequence: MSQRGISKGLLVCHSVRLAKVWVDQIEISIPLGVEPEPKQIEGISDLIDSLHSYDCSVCSVVAHKLDDAMCRWCELLLDA
What are the official names of this protein?
Uncharacterized protein Gp-e.
Protein: EST1D_MOUSE
Sequence: MGLYPLIWLSLAACTAWGYPSSPPVVNTVKGKVLGKYVNLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNIYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDVKPIAGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGVVLPKAPEEILAEKSFSTVPYIVGINKQEFGWIIPTLMGYPLAEGKLDQKTANSLLWKSYPTLKISENMIPVVAEKYLGGTDDLTKKKDLFQDLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYRPSFVSAMRPKAVIGDHGDEIFSVFGSPFLKDGASEEETNLSKMVMKFWANFARNGNPNGGGLPHWPEYDQKEGYLKIGASTQAAQRLKDKEVSFWAELRAKESAQRPSHREHVEL
What is the function of this protein?
Major lipase in white adipose tissue.  Involved in the metabolism of xenobiotics and of natural substrates.  Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols.  The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety.  Catalyzes the synthesis of fatty acid ethyl esters (PubMed:15220344).  Hydrolyzes retinyl esters (By similarity).
What are the official names of this protein?
Carboxylesterase 1D, Carboxylesterase 3, Fatty acid ethyl ester synthase, FAEE synthase, Triacylglycerol hydrolase, TGH.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Cytoplasm, cytosol. Lipid droplet. Microsome.
Protein: CYB_CROAL
Sequence: MTNIRKRHPLIKIVNESFIDLPTPPNISDWWNFGSLLGVCLVLQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWIIRYIHANGASMFFICLFMHVGRGMYYGSYLFMETWNIGILLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTSLVEWIWGGFSVDKATLTRFFAFHFILPFIISALAVVHLLFLHGTGSNNPSGISSDSDKIPFHPYYTIMEILGLLTMLAMLMILVVFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSIMILAITPLLHTSNQRSMTFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFIIIGQLASILYFSIILIFMPISGTIENQLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FTSH_MESFL
Sequence: MKTKKSKSTLWFWLIILLAIIVTIIIIAVTVKGTTQVISDATFADWMSKSPQIDPNADKYWKNVIIYYGSNNTVVVKGSYFLESTGKYVNFVAYLTQKRFETIMADKPYPWPALVYQGSVGMALLVSLAPLLIYVLLFGGIIWFMMKSSSGAGAGAGNIFGMGKNRARAEKSDVKFANVAGIEEEKSELVELVDYLKFPAKYAEAGARAPKGVLMEGPPGTGKTLLAKAVAGEAGVSFFSIAGSEFEEMFVGVGASRVREMFNDAKKSAPAIIFIDEIDAVGRKRNNGMGSGGNEQTLNQLLVEMDGFGTNSGIIVMAATNRADVLDPALLRPGRFDRVIQVSLPDIKERKAILELHAKGKKIDGSVDWYRVAERTPGFSGAQLENVLNEAAILMVREKRDIITITEIDEAIDRVVGGPAKKSRAMTKQDKDIVSYHESGHALIGLKLDSASKVQKVTIIPRGNAGGYTIMTPKDETVFSSKKDLFATIAGYLGGRAAEEIMFGKENVTTGAHDDLDKATNIARRMVVQFGMSSLGMTKFLTMAEESYGKMEGTYSDETAARIDAEISKILEESYKIALKIIKENMETLELLAESLRVLETITAEQIEYINVNKKLPEEVLEQKNRMAKEDEKIKKGEIIDIKVEDLDID
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.