PharMolix/UniProtQA huggingface dataset:
Protein: DAPF_STRCO
Sequence: MSTRIAFLKGHGTENDFVIVPDPENALDLPPAAVAALCDRRAGLGGDGLLHVVRSAAHPEARGMAAEAEWFMDYRNGDGSVAEMCGNGVRVFARYLQHAGHVTEGDLAVATRGGVKTVHIAKNGDVTVGMGRALLPAGDVEVSVGEREWPARNVNMGNPHAVAFVADLDHAGDLYAPPSHAPAGAYPDGVNVEFVVDRGPRHVAMRVHERGSGETRSCGTGACAVAVATARRDGLDPAATGTPATYTVDVPGGTLVITERPDGEIEMTGPAVIVAEGEFDSAWLEGVLA
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPIA_BUCBP
Sequence: MKTNELKRLVARKVVDYINPGSVIGIGTGSTVSYFIEVLSTIKNLISGAVSSSNFSTACLKRIGIPIYDLSKINSLVLYIDSADEINPQLQMIKGGGAALTREKIIAATAEKFICIADESKQVEILGKVPLPIEIIPMARSYISNEIIKIGGMPKYRKNVITDNGNVIIDVFNLVITDPVCLENKINSFPGVVSVGLFATRKADIALIGTSSGVQVIY
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: DIDS_ECHCA
Sequence: NSVHPCCDPVICEPREGEHCISGPCCENCYFLNSGTICKRARGDGNQDYCTGITPDCPRNRYNV
What is the function of this protein?
May bind to both alpha-IIb/beta-3 (ITGA2B/ITGB3) and alpha-V/beta-3 (ITGAV/ITGB3) integrins, and may inhibit platelet aggregation.
What are the official names of this protein?
Disintegrin schistatin.
What is the protein family that this protein belongs to?
Belongs to the disintegrin family. Dimeric disintegrin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AZOR_SALTY
Sequence: MSKVLVLKSSILAGYSQSGQLTDYFIEQWREKHVADEITVRDLAANPVPVLDGELVGAMRPGDAPLTPRQQDALALSDELIAELKAHDVIVIAAPMYNFNIPTQLKNYFDLIARAGITFRYTEKGPEGLVTGKRAVVLSSRGGIHKDTPTDLIAPYLKVFLGFIGITDVNFVFAEGIAYGPEVAAKAQADAKAAIDSVVAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: PXL2C_MOUSE
Sequence: MAAPVTRQVSGCAGRVPSPAGSVTERGQPLAAAVAELPVLDASGRRVTFGALFRERRAVVVFVRHFLCYVCKEYVEDLAKIPKSVLREADVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEEISSSGQSPHIKSNLLSGSLQSLWRAVTGPLFDFQGDPAQQGGTLILGPGNNIHFVHRDRNRLDHKPINSVLQLVGVQPVNFMSRPTVIHV
What is the function of this protein?
May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis.
What are the official names of this protein?
Peroxiredoxin-like 2C, AhpC/TSA antioxidant enzyme domain-containing protein 1, Thioredoxin-like protein AAED1.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily.
Protein: RS11_SALPC
Sequence: MAKAPVRARKRVRKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: SYM_FRAT1
Sequence: MRKILVTNALPYANGDLHLGHMLGYIQSDIWVRFQKLQGNQCIFVCGSDTHGTPIMLKAKSLGITPEELVTKYSNRHLQDFTDFEINFDNYHSTHNSLNKEIVEDIYNKLNNKNLISKKAIAQAYDPEAKMFLPDRFVKGTCPKCKAEDQYGDSCEVCGATYDPTELINPRSVISGQSPIQKNSEHFFFDLPALEKNIKDWIESNTLLQPEVANKLAEWFEQGLQSWDISRDAPYFGFAIPGTNEQKFFYVWLDAPMGYIASFKDYCNKNNINFGDFWGDSSSESELYHFIGKDIIYFHTLFWPAILSSTGYKTPTSVFANGFLTVNGKKMSKSRGTFIQARTYLDNLEPSYLRYYFASRLTSRIDDIDLNLEEFVTKSNSDIVGKVVNIASRCAGFIYKKFDATLSGEIFDPELESEFSKNHDAITQAFEKREFAHAVRLIMALADKANQFIDYHKPWQLAKEEGQEQKVHQVCSQGINMFKVLIVYLKPIIPSIVAEAERFLNIQFISWADAPKFLINHKIDKFKPLATRIEKEKVDKILEDTKKMLENEQSPQSKKEEPKLDIAAECTFDDFMKVDLRIAKITEASHVEGADKLLKLILDLGGVTKQVFAGIKSAYKPEDLIGKHTIMVANLAPRKMKFGMSEGMVLAAGDGKGIYILEPHEGAQPGMRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_STAES
Sequence: MSRVGKKIIDIPSDVTVTFDGSHVTVKGPKGELERTLNERMTFKQEENTVEVVRPSDSKEDRTDHGTTRALLNNMVLGVSQGYEKTLELVGVGYRAQMQGKDLVLNVGYSHPVEIKAEEGITFAVEKNTTVKVSGVSKEQVGAIASNIRSVRPPEPYKGKGIRYQGEYVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: CH60_NEOYE
Sequence: MSKQILYQDDARKALEKGMDILTEAVSVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEISLENHIENTGVALIRQAASKTNDVAGDGTTTATVLASAIVKQGMRNVAAGSNPMAIKKGIEKATNFVVSKIAEYAKPVEDTKAIIQVASLSSGNDIEVGKMIANAIEKVGREGVISLEEGKSTNTILEITEGMQFEKGFISPYFVTDTERMEVLQENPFILFTDKKITLVQQELVPLLEQIAKTSRPLLIIAEDIEKEALATIVVNKLRGILNVVAVRAPGFGDRRKSLLEDMSILTNGQVITEDAGLSLDTVQLDMLGKARRVIVTKDSTTIIADGHEIKVKSRCEQIKRQIETSDSLYEREKLQERLAKLSGGVAVIKVGAATETEMKDKKLRLGDAINATKAAIEEGIVPGGGATNVHISSELFTWAKNNLVEDELIGALIVERAVTYPLRRIAFNAGDNGAVIVEKVKSHDFHIGYDAANGNIVNMYDRGIIDPAKVARSALQNAASIAAMVLTTECIVVDKVDD
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, chloroplastic, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SPIKE_CVRSD
Sequence: MLFVFLTLLPSCLGYIGDFRCINLVNTRISNARAPSVSTEVVDVSKGLGTYYVLDRVYLNATLLLTGYYPVDGSMYRNMALMGTNTLSLNWFEPPFLSEFNDGIYAKVKNLKASLPIGSASYFPTIIIGSNFVNTSYTVVLEPYNGIIMASICQYTICQLPHTDCKPNTGGNTLIGFWHTDLRPPVCILKRNFTFNVNAEWLYFHFYQQGGTFYAYYADVSSATTFLFSSYIGAVLTQYFVLPYMCSPTTSGVSSPQYWVTPLVKRQYLFNFNQKGIITSAVDCASSYTSEIKCKTQSMNPNTGVYDLSGYTVQPVGLVYRRVRNLPDCKIEEWLAANTVPSPLNWERKTFQNCNFNLSSLLRFVQAESLSCSNIDASKVYGMCFGSISIDKFAIPNSRRVDLQLGKSGLLQSFNYKIDTRATSCQLYYSLAQDNVTVINHNPSSWNRRYGFNDVATFHSGEHDVAYAEACFTVGASYCPCAKPSTVYSCVTGKPKSANCPTGTSNRECNVQASGFKSKCDCTCNPSPLTTYDPRCLQARSMLGVGDHCEGLGILEDKCGGSNICNCSADAFVGWAMDSCLSNARCHIFSNLMLNGINSGTTCSTDFQLPNTEVVTGVCVKYDLYGSTGQGVFKEVKADYYNSWQNLLYDVNGNLNGFRDIVTNKTYLLRSCYSGRVSAAYHQDAPEPALLYRNLKCDYVFNNNISREETPLNYFDSYLGCVINADNSTEQSVDACDLRMGSGLCVNYSIAHRARRSVSTGYKLTTFEPFTVSIVNDSVESVGGLYEMQIPTNFTIASHQEFIQTRSPKVTIDCAAFVCGDYTACRQQLVDYGSFCDNINAILGEVNNLIDTMQLQVASALIQGVTLSSRLADGISGQIDDINFSPLLGCLGSDCSEGTKAAQGRSAIEDVLFDKVKLSDVGFVESYNNCTGGQEVRDLLCVQSFNGIKVLPPVLSESQISGYTAGATASAMFPPWSAAAGVPFALSVQYRINGLGVTMNVLSENQKMIASSFNNAIGAIQEGFDATNSALAKIQSVVNANAEALNNLLNQLSNRFGAISASLQEILSRLDALEAQAQIDRLINGRLTALNAYVSKQLSDMTLIKVSAAQAIEKVNECVKSQSPRINFCGNGNHILSLVQNAPYGLYFIHFSYVPTSFTTVNVSPGLCISGDRGLAPKAGYFVQDHGEWKFTGSNYYYPESITDKNSVVMSSCAVNYTKAPEVFLNTSITNLPDFKEELDKWFKNQTSIVPDLSFDIGKLNVTFLDLSYEMNRIQDAIKNLNESYINLKEIGTYEMYVKWPWYVWLLIGLAGVAVCVLLFFICCCTGCGSCCFKKCGNCCDEYGGRQAGIVIHNISSHED
What is the function of this protein?
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell- cell fusion.
Protein: TATA_CAUSK
Sequence: MGGMSWIHWVIVIAVVALLFGGRGKLSGIMGDAAKGIKAFKDGLKDDSSDEVSANKATGALPRTEAEKEDLRKS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MATK_CALDE
Sequence: MDEFQRNSNKHRSWQQFFLYPLFFREDLYAIAHDHHLHRSGSSEPTEILVSNFVSFLTVKRSIRRIRKQNNSISLFGNSDSNKFIEYNKNFSFKSILEGFTIVLEVSFAMRSKHFIKGMDGWNSLRSIHCIFPFMEDKLPHSNYISDIRVPYSIHPEILVRIFRRWILDAPSLHLLRLILHECSFSRENLQKAMITQRENTRFSLFLWNSYVYECESFLIPLIKRFFNSQSLLYGSFPDRTHFEKKIKDIVLFPLQKISTKKIWLLKDSFIHYVRYGERSLIALKGTHLQVKKCRYHLFHFLQYYFHLWFQPYRICSLELSKTSFSFLGFFMHVKMRPLVVRAKMLDDLFITDLITNELNSTAPLKSILFSLAKEKFCDISGWPISKLSWTSLSDDDILDRFDRIWINLFHYYSGSINQDGLYHIKYILLISCAKTLACKHKSTIRVVREQLGSELFTKSFSKERESISSSFSKTRSQRERIWNSEISQITPLASFWQKMENKQIEN
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TTC7A_HUMAN
Sequence: MAAKGAHGSYLKVESELERCRAEGHWDRMPELVRQLQTLSMPGGGGNRRGSPSAAFTFPDTDDFGKLLLAEALLEQCLKENHAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVIKGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLKGCHPLDYELTYFLEAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEESSFATQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPVLPFSIIPREL
What is the function of this protein?
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819).  The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable).  In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity).
What are the official names of this protein?
Tetratricopeptide repeat protein 7A, TPR repeat protein 7A.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with EFR3 (EFR3A or EFR3B).
Protein: CUTA_ARATH
Sequence: MASSLTTRLSAVIGSRRSFPIVGAFCVLSTLSISSLSSSSPFKSGCAQSFSVVPLLRSKFSSKAFSSSIRMEESSKTVPSIVVYVTVPNREAGKKLANSIVQEKLAACVNIVPGIESVYEWEGKVQSDSEELLIIKTRQSLLEPLTEHVNANHEYDVPEVIALPITGGSDKYLEWLKNSTRN
What is the function of this protein?
Involved in metal homeostasis.  Specifically binds Cu(2+).  The truncated isoform has less specificity in metal binding.
What are the official names of this protein?
Protein CutA, chloroplastic, Copper-binding protein CutA, AtCUTA.
What is the protein family that this protein belongs to?
Belongs to the CutA family.
Protein: SECA_SHIFL
Sequence: MLIKLLTKVFGSRNDRTLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVLENLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGLTVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKRVNKIIPHLIRQEKEDSETFQGEGHFSVDEKSRQVNLTERGLVLIEELLVKEGIMDEGESLYSPANIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLNAKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKADWQVRHDAVLEAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYSQRNELLDVSDVSETINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLDLPITEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEELEQQRRMEAERLAQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCPCGSGKKYKQCHGRLQ
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: PQQC_RUEPO
Sequence: MSREDLEARLRAIGAERYHDKHPFHHKLHGGDCTPDQVRAWVINRWAYQAAIPMKDAAFLSRCADPDIRRAWRSRIEDHDGGVDSGGGLRRWLKLAEAVGLDPDYVASGRGILPATRFAVEAYFHYVREQPLLQAVASSLTELFAPKIHENRIEGLLRHYDFADESSLSYFRKRLSEAPRDVAYGLGWVLDHADTPEKEDMACAALIFKTDVLWAQLDALWGAYVDGHVPPGAWRPGEGMA
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: CRIP3_HUMAN
Sequence: MSWTCPRCQQPVFFAEKVSSLGKNWHRFCLKCERCHSILSPGGHAEHNGRPYCHKPCYGALFGPRGVNIGGVGSYLYNPPTPSPGCTTPLSPSSFSPPRPRTGLPQGKKSPPHMKTFTGETSLCPGCGEPVYFAEKVMSLGRNWHRPCLRCQRCHKTLTAGSHAEHDGVPYCHVPCYGYLFGPKGGQPHPRHWDGMYMPEVWHVHGLWVCVDNFPCG
What are the official names of this protein?
Cysteine-rich protein 3, CRP-3, Chromosome 6 LIM domain only protein, h6LIMo.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FHLA_ECOLI
Sequence: MSYTPMSDLGQQGLFDITRTLLQQPDLASLCEALSQLVKRSALADNAAIVLWQAQTQRASYYASREKDTPIKYEDETVLAHGPVRSILSRPDTLHCSYEEFCETWPQLDAGGLYPKFGHYCLMPLAAEGHIFGGCEFIRYDDRPWSEKEFNRLQTFTQIVSVVTEQIQSRVVNNVDYELLCRERDNFRILVAITNAVLSRLDMDELVSEVAKEIHYYFDIDDISIVLRSHRKNKLNIYSTHYLDKQHPAHEQSEVDEAGTLTERVFKSKEMLLINLHERDDLAPYERMLFDTWGNQIQTLCLLPLMSGDTMLGVLKLAQCEEKVFTTTNLNLLRQIAERVAIAVDNALAYQEIHRLKERLVDENLALTEQLNNVDSEFGEIIGRSEAMYSVLKQVEMVAQSDSTVLILGETGTGKELIARAIHNLSGRNNRRMVKMNCAAMPAGLLESDLFGHERGAFTGASAQRIGRFELADKSSLFLDEVGDMPLELQPKLLRVLQEQEFERLGSNKIIQTDVRLIAATNRDLKKMVADREFRSDLYYRLNVFPIHLPPLRERPEDIPLLAKAFTFKIARRLGRNIDSIPAETLRTLSNMEWPGNVRELENVIERAVLLTRGNVLQLSLPDIVLPEPETPPAATVVALEGEDEYQLIVRVLKETNGVVAGPKGAAQRLGLKRTTLLSRMKRLGIDKSALI
What is the function of this protein?
Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes.  Also activates expression of hyf operon (encodes the silent hydrogenase-4 gene cluster) (PubMed:12426353).
What are the official names of this protein?
Formate hydrogenlyase transcriptional activator FhlA.
Protein: DCTA_PSECL
Sequence: MTTRQPLYKSLYFQVIVAIAIGILLGHFYPQTGVALKPLGDGFIKLIKMVIAPIIFCTVVSGIAGMQNMKSVGKTGGYALLYFEIVSTIALLIGLVVVNVVQPGNGMHIDVSTLDASKVAAYVTAGKDQSIVGFILNVIPNTIVGAFANGDILQVLMFSVIFGFALHRLGAYGKPVLDFIDRFAHVMFNIINMIMKLAPIGALGAMAFTIGAYGVGSLVQLGQLMICFYITCVLFVLVVLGAICRAHGFSVLKLIRYIREELLIVLGTSSSESALPRMLIKMERLGAKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATDTHMDITHQITLLLVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNAVATVVVAKWVKELDEDQLQAELASGGRAISDTREEDDLGVAEGPTPTTVK
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RGS8_DANRE
Sequence: MKTRLGCLSNKSDSCSDFSEFLPPAQERTTRCLKLSNDEVTRWADSFDILLSNKYGLAAFRTFLKTEFSDENIEFWLACEDYKKIKSPAKMMSKANKIYKEFIDVHAPREVNIDHRTREETKNRLLEPTPHSLNEVQAKVYSLMEKDSYPRFIRSKIYQDLLNRTQIYCQRKSV
What is the function of this protein?
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptors and dopamine receptors.  Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.  Modulates the activity of potassium channels that are activated in response to G protein-coupled receptor signaling.
What are the official names of this protein?
Regulator of G-protein signaling 8, RGS8.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, dendrite. Nucleus. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1.
Protein: UPPP_SULIN
Sequence: MNFLVSILLGIIQGISEWLPISSKTQELIASHYLLGLDVSIAYTFGLFMEMGSIGSALIYFRQDVKRVFHDKFLLKFLVVVTALTGIVGVPLYVISDKLLQNAYNPSIPMIFLGIALIADGIYIRYSRSRTREFKNLSTKEMILIGIAQGIAALPGVSRSGMTVSTMLVLGINPEDAFHYSYLAYIPAAIGSVGTTLLFTRHHISYVVSLIGIDGIALAVISALLTGLVVIGFLLKIAKTKKVYLIDFMLGGIAVLVSMLGLIIS
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
What are the official names of this protein?
Undecaprenyl-diphosphatase, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COBS_SULIK
Sequence: MRLKGVLALFSFFTAIPIKSNASLEEIAEYSYISPLIIGISLALIESAVYVLLYRILEALAGIVLLGVVELLRGFNHLDGLLDLGDALMIKGDRERKIKALKDVEIGSGGIGLLLVYLSIQIVALLKLGFSFYTIFYLISSNVLSMTIGLYILSTISPIPESNLGKIFHNKLKGKSTVLLFELIPFISLYNIIVFLVFYMIMHKICRSLGGSSGDIAGASITLSFPLFLLTNEITNLNYSLLSILCYLFLHLH
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HLAE_HUMAN
Sequence: MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL
What is the function of this protein?
(Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32859121).  Binds SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening antiviral immune surveillance (PubMed:32859121).
What are the official names of this protein?
HLA class I histocompatibility antigen, alpha chain E, MHC class I antigen E.
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane. SUBCELLULAR LOCATION: [Soluble HLA class I histocompatibility antigen, alpha chain E]: Secreted.
Protein: RS14_RICFE
Sequence: MAKVSSIKKNESRKKKSQSLHNKRSALKSKIYDKNISLEERFSLVMSLAQLPRNSSSTRIRNRCELTGRPRGVTRKFGISRNKLRELIGRGLVPGVVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: HSLV_WOLPP
Sequence: MIHHDSSKMYGTTILSIRRDKNVVVIGDGQVSLGHTVIKSGARKVRRLSGDSVIAGFAGATADAFTLFERLESKLDKHPGQLMRACVELAKDWRMDKYLRKLEAMMIVADKSISLVITGTGDVLEPEDGIAAIGSGGNFALSAAKALIDVEGISIEEIAKKAMKIAADICVYTNHNLIIEKIEE
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOVH_STRNV
Sequence: MFNTRANKASDQSPTIPTESATLAELWERTVRSRPSSPAIVTNGETLSYDEVNARANRLARLLLDEGAGPGRLVALALPRSSHLVISVLAVAKAGAVFLPLDVNHPRERLSYQLADARPALLCTVRSAAARLPDGIEMPRVLLDSPERTAVLDALPDTDLTDDERGGPLAATDLAYVIYTSGSTGRPKGVALTGAGLPALAAAKVAAMRVTGDSRVLQFASPGFDAYLTELLAAFTAGATLVVPGTDTLAGDPLRRALRDGRVSHAVLPPAAVATMSPDAVPDLRVLVVAGEACPAGLVERWAPGRLLINAYGPTECTVCATMTGPLTPTDEVTIGRPIPGVSVYILDAERRPAAPGEIGELYLSGAGLAQGYLNSPDLTAQMFVPNPFAADGERMYRTGDLASRRADGDILFHGRIDDQVELRGFRVELGEVESVLSQHPDVAQAVAALWTDPAEGPQLVTYVVPAPGTTPSAGELREHAGRFLPDFMVPSAFTTIDAVPLTPGGKTDRAGLPDPVKATQPAGLGPRTPAEKVLCDIFRDLFDLVEIDVRSNFFEMGGNSILAVDLIQRAQEAGLTLMPRTVIDHPTIEQLAAIATLEE
What is the function of this protein?
Together with NovI, involved in the formation of a beta-OH-Tyr intermediate in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases.  The ATP-dependent AMP-binding region activates L-Tyr as L-tyrosyl-AMP and then transfers the L-tyrosyl group to the acyl carrier domain through thioester formation to form a tyrosyl-S intermediate that is covalently tethered to NovH (L-Tyr-S-NovH).
What are the official names of this protein?
Novobiocin biosynthesis protein H.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.