PharMolix/UniProtQA huggingface dataset:
Protein: MED4_ASHGO
Sequence: MSANQLSKAATPKATPLGAAQGASSTSLHSFTSFQPQDASHVEQNKLHSVAIYEDLCQYEESLQRLVTSVDKFQPDLEAAQELIEIDSKLYSNLAQLPKYDLIDSQLKKLEEESKDIDERTAKILGILGECYNDLNSLPMVEQVEFEMATMKKQKDKVNSSVLLEYAMKLSKFTRVPPTFNKDAIGPNNFIWPAEDAIRRGMLAMASLKSKELTSLPGQSDQEAEQASAGKEADTAGPGVSTLEPANGGHNRRGSFEFTGIRKPPPASDADSSVVDDGDASMDLDLNLFNPDEF
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 4, Mediator complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ECFT_BACIE
Sequence: MFDSIIIGQYVPGDSVVHRLDPRVKLTAVFIFLVFMFMTRDPLLLTVAVLLSFGGLLASRVPLSFYAKGMRFISIIIVLTFVLHLFMTGGGEVIVELPFATIYSGGLIEGFMLAMKLAMIITIASLLTLTTTPIDLTDGMERMLAPFKRVKLPTHELALMMSIALRFIPTLIEETRTIVLAQLARGTNFSEGSLWKRLKALIPILVPLFTQSFKRAEELATAMEARGYAGGEGRTKYRQLHWGLKDSVVLAVFLLFAAAVMAERFMGG
What is the function of this protein?
Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter transmembrane protein EcfT, ECF transporter T component EcfT.
What is the protein family that this protein belongs to?
Belongs to the energy-coupling factor EcfT family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SMS2_ONCMY
Sequence: MKVCRIHCALALLGLALAICSQGAASQPDLDLRSRRLLQRARAAAWPHRSGVSERWRTFYPNCPCLRPRKVKCPAGAKEDLRVELERSVGNPNNLPPRERKAGCKNFYWKGFTSC
What is the function of this protein?
Somatostatin inhibits the release of somatotropin.
What are the official names of this protein?
Somatostatin-2, Somatostatin II.
What is the protein family that this protein belongs to?
Belongs to the somatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FIP1X_SCHPO
Sequence: MSNADQHMDVDEDEYLYGETIEERNDGVTVSNAKSPEQASEESDDSDIEFIIETKPGERAEPLGGSIATLGSTRPSAKPQVEKTAVEVKTTEPQDLSTAETAPKVDIDAVPTIDGKNIFEIDLESFDDKPWRKPGADISDYFNYGFDEFTWAAYCAKQTTLRDDFSPQKFMASLAQIPGPLPSGNVPSPAEFQAMMASGFPPFMPIPPPIGGPQEDMGYSRNFPVHASSNYNTTHTSGGGVHSGAATPNAYVNNNPSSSRRESESPANSPNITSSAGMTHAQPTHNPTSSYGNGASTNYNASRPPSNHPHSSNYPSSSRRKPSPDRYSNYSSRGSGGRYRRNRY
What is the function of this protein?
Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase.
What are the official names of this protein?
Pre-mRNA polyadenylation factor fip1.
What is the protein family that this protein belongs to?
Belongs to the FIP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYNS_BURMA
Sequence: MTQSQHSQSPREALAERIVEAKTRKNLTFEQINEGTGLSVAFTTAALLGQHPLPADAARVVAAKLDLDDDAQRLLQTIPVRGSIPGGVPTDPTIYRFYEIVQVYGSTLKALIHEQFGDGIVSAINFKLDIKKVDDPEGGSRAVITLDGKYLPTKPF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: PYRI_SALPC
Sequence: MTHDNKLQVEAIKCGTVIDHIPAQVGFKLLSLFKLTETDQRITIGLNLPSGEMGRKDLIKIENTFLTEEQVNQLALYAPQATVNRIDNYDVVGKSRPSLPERINNVLVCPNSNCISHAEPVSSSFAVKKRANDIALKCKYCEKEFSHYVVLAN
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: INHA_CHICK
Sequence: MLLLLHLLPAVLPASALGSCTGAGADRQLVLAKVRARVLEHLSPPAMQEPQKDVRRVHRRDVLEEVEVPPEEQEDTSQVILFPSTDVPCEPTQPDKLLEEEGIFTYLFQPSAHALSRTLTSAQLWFYSGPSAAPNHSAPAVLTLSPQGRVPVVATASRTPEHWTVFDFGPDALPQLAQPLFVLLVRCPGCPCLADGDKMPFLVATTRAKAAGRARRSAVPWSPAALSLLQRPSEDVAAHTNCRRASLNISFEELGWDNWIVHPSSFVFHYCHGNCAEGHGLSHRLGVQLCCAALPGTMRSLRVRTTSDGGYSFKYETVPNILAQDCTCV
What is the function of this protein?
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.  Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.  Inhibins appear to oppose the functions of activins.
What are the official names of this protein?
Inhibin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: HFQ_SHIFL
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQIESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNNAGGGTSSNYHHGSSAQNTSAQQDSEETE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: GATA_PAEAT
Sequence: MTELKNELIRHSAADLAAKLASREVTAVEVTQAHLDRIADVDGQVNAFLHVNSEEALAVAAEVDAARAAGGSAAEELHALAGVPIAVKDLIVTIGQPTTAGSKILEGWHSPYDATVVKKLRAAKMPILGKTNLDEFAMGSSTEHSAYGPTRNPWDLDRIPGGSGGGSAAAVAAFEAPLALGTDTGGSIRQPGAVTGTVGVKPTYGAVSRYGAIAMASSLDQIGPVSRTVLDSALLQEVIGGHDPFDSTSLTDPFNDLVAAARVGNVAGMKIGIVKELHGEGYQAGVENRFNESLQLLKDAGAEIVEVSCPNLKYALGAYYLIMPSEVSSNLAKFDGVRFGMRVLPKDGPMTIERVMGATRAAGFGDEVKRRIILGTYALSAGYYDAYYGSAQKVRTLIQRDFDAAFAKADVLISPTAPTTAFKLGEKLDDPLAMYLNDVATIPANLAGIPGLSLPGGLADEDGLPVGIQLLAPARQDARLYRVGAVLESILEEKWGGPILAQAPDLKTAVLGAVSTTAGGSN
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: RR8_LOLPR
Sequence: MGKDTIADLLTSIRNADMNKKGTVRVISTNITENIVKILLREGFIESVRKHQERNRYFLVSTLRHQKRKTRKGIYRTRTFLKRISRPGLRIYTNYQGIPKVLGGMGIAILSTSRGIMTDREARLNRIGGEVLCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CXE16_ARATH
Sequence: MPGVAVKLYSVFFKLLLKHRLQNLISISAADGLSDSFGVSTRSDESVAAANPSFTDGVATKDIHIDPMTSLTVRIFLPESALSPEPDSLRHKDNYNHQPRSDRRHSYGPNHNSPAPAERNESRRNSYGCNNENLEPYGGYAPSAKRNSRKLPVMLQFHGGGWVSGSSDSAANDFFCRRIAKVCDVIVLAVGYRLAPENRYPAAFEDGVKVLHWLGKQANLADCCKSLGNRRVNGVEVKKLNVQGQIVDAFGASMVEPWLAAHADPSRCVLLGVSCGGNIADYVARKAVEAGKLLEPVKVVAQVLMYPFFIGNNPTQSEIKLANSYFYDKPVSVLAWKLFLPEKEFDFDHPAANPLAHNRSGPPLKLMPPTLTVVAEHDWMRDRAIAYSEELRKVNVDSPVLEYKDAVHEFATLDMLLKTPQAQACAEDIAIWVKKYISLRGHEFSY
What is the function of this protein?
Carboxylesterase acting on esters with varying acyl chain length.
What are the official names of this protein?
Probable carboxylesterase 16, AtCXE16.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
Protein: ATPB_COXBU
Sequence: MTTAKSGTTIEIIGAVVDVEFPRHAVPKVYDALQVDENNLTLEVQQQLGDGVVRTIAMGSTEGLKRDIAVKNTEKPIEVPVGKETLGRIMNVLGEPIDELGPINSKEKLPIHRPAPSFIEQSGATELLETGIKVVDLLCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMKESNVLDKVALVYGQMNEPPGNRLRVGLTGLTLAEAFRDEGRDVLLFIDNIFRYTLAGVEVSALLGRMPSAVGYQPTLAEEMGALQERITSTKKGSITSIQAVYVPADDLTDPSPATTFAHLDATVVLSRQIAERGIYPAIDPLDSTSRQLDPLIIGEEHYRVARGVQETLQRYEELKDIIAILGMDELSEDDKRAVRRARKIQRFLSQPFFVAEVFTGAPGKYVSLQDTIRGFKGIINGEYDELPEQAFYMVGSIEEAVEKAKSL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL25_LEIXX
Sequence: MADESNKVAAEVRDSFGKGAARKIRAAGKIPAVIYGHGSEPVHITLPAHQVGLLLRKANAVLDIDIAGKTQLALVKDVQKDPVLQIIEHLDLLVVRRGEKVQVEVPVHVEGEPFSGTIAMLDIPTIKLEVEATNIPERIVIDVTGAEEGTQYHAKDFALPAGAVLAEDEDLLLLNIIVPAAARAEDEEAVVEAAGDQAAE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: RL16_DECAR
Sequence: MLQPNRRKFRKEHKGRNEGLATRGTKVSFGEWGLKAIGRGRLTARQIEAARRAMTRHIKRGGRIWIRIFPDKPISKKPAEVRMGNGKGNPEYWVAEIQPGKVLYEMDGVNEALAREAFALAAAKLPIPTTFVTRHLG
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: Y1706_SHEWM
Sequence: MQYLVDVHAHTIASTHAYSTIHDYISVAKEKGLKLFAVTDHGPDMADAPHFWHFVNMRVLPRLVDGIGILRGIEANIKNRDGEIDFFGDYLKELDIVLAGFHEPVFPPSDRQTHTQAMISTIESGNVDIITHPGNPAYPIDIDKVAEAAAKHNVALEINNSSFLASRKGSEGNCIAIARAVHDAGGLLVMGSDSHISFSLGGFEQAILVIREAEFPEERLLNRSPQALLSFLSERGHDSLDEYSVLLRS
What are the official names of this protein?
Probable phosphatase Swoo_1706.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: NFRA_STAS1
Sequence: MSEHVYNLLKNHHSVRKFKKEPISEAHIKQLVEAGQNASTSSYLQAYSIIGINDPEIKEELKEVSGQPYVVENGYLFVFVMDYYRHSIINEESKHDMQTSFESAEGLLVGTIDATLVAQNIAATAEDMGYGMVYLGSLRNDVERVREILELPKHTFPLFGMALGIPEDDENGSPKPRLPFEHVFHANKYDSDKDSQRETLKAYDQTVSDYYSSRTNGERTESWSNQVANFMSAKQRLDMLEQLNKSGFIKK
What is the function of this protein?
Reduces FMN, organic nitro compounds and disulfide DTNB.  Involved in maintenance of the cellular redox state and the disulfide stress response (By similarity).
What are the official names of this protein?
NADPH-dependent oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the flavin oxidoreductase frp family.
Protein: SYA_HAEIE
Sequence: MKTTAEIRQSFLDFFHSKGHQVVESSSLVPENDPTLLFTNAGMNQFKDVFLGMDKRPYSRATTAQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKQDAINFAWEYLTSPQWLGLPKEKLWVTVYETDDEAYNIWNKEVGVPAERIIRIGDNKSAPYASDNFWAMGDTGPCGPCTEIFYDHGDHIWGGPPGSPEEDGDRYIEIWNVVFMQFNRLADGTMEKLPRPSVDTGMGLERISAVLQHVNSNYEIDIFKTLIAKTAEIVGATDLTNKSLRVIADHIRSCAYLIADGVIPSNEGRGYVLRRIIRRAVRHGHLLGAKESFFYKLVPTLIDVMAEAGKDVKAKQTNVEKLLRLEEEQFARTLERGLSLLDEALSQVKDGILSGEVAFKLYDTYGFPLDLTADVCRERNITIDEQAFDREMEAQRTRAQAASQFGVDYNSIIRVDGETKFEGYTEVESQAKITALFYDGKSVESIEAGQSAVVILENTPFYAESGGQIGDSGYLSAQGVTFNVKDTQKYGQVFGHIGELTQGSLKVGQSVNAIVDAKRRHNTSLNHSATHLLHAALRQILGLHVVQKGSLVSDKALRFDFAQPEAITKEQLTQIETLVNQKIRANFPVQTDIMDIDSAKAKGAMALFGEKYGDKVRVLTMGDFSIELCGGIHAKRTGDIGLFKIITENAVAAGIRRIEAITGQNAIDWLHNQQRILTQSADLLKSDVNTLVEKIQQLQDKTKKVEKELQGLKEKAAMQAGSDFVKSAVKINGVSVITQQLDGIETKSLRVMVDDLKNQLGSGVIAFASILDEKVNLVVGVTNDLTAKIKAGELVNLMAQQVGGKGGGRPDMAMAGGSQPENVAQAIKVAQDWLNKNL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROCE_OLEEU
Sequence: MSWQTYVDEHLMCEIEGLHLASTAIIGHAGTVWAQSTAFPQFKPEEITGIMKDFDEPGHLAPTGMFVAGAKYMVIQGEPGAVIRGKKGAGGITIKKTGQALVVGIYDEPMTPGQCNMVVERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-3, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y921_STRR6
Sequence: MPFVRIDLFEGRTLEQKKALAKEVTEAVVRNTGAPQSAVHVIINDMPEGTYFPQGEMRTK
What are the official names of this protein?
Probable tautomerase spr0921.
What is the protein family that this protein belongs to?
Belongs to the 4-oxalocrotonate tautomerase family.
Protein: RL14_LACAC
Sequence: MIQNESRLKVADNSGARELLVIRVLGGSKRKTGNIGDIVVCTVKQATPGGVVKKGDVVKAVIVRTKSGARREDGSYIKFDENAGVIINADKSPRGTRIFGPVARELRENDFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: TPIS_SALPA
Sequence: MRHPLVMGNWKLNGSRHMVNELVANLRKELAGVAGCDVAIAPPEMYIDLAKRAAAGSHIMLGAQNVDLNLSGAFTGETSAEMLKDIGAQYIIIGHSERRTYHKESDELIAKKFAVLKEQGLTPVLCIGETEAENEAGKTEEVCARQIDAVLKTQGAAAFEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRDHIAKADAKIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGASLKADAFAVIVKAAEAAKQA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_STRMU
Sequence: MKIADKTVTRAILERHGFTFKKLFGQNFLTDTNILQKIVDTAEIDKTVNVIEIGPGIGALTEFLAENAAEVMAFEIDDRLVPILADTLRDFDNIKVVNEDILKSDLQTRIKEFANPDLPIKVVANLPYYITTPILMHLIESKIPFAEFVVMMQKEVADRISAQPSTKAYGSLSIAVQYYMTAKIAFIVPRTVFVPAPNVDSAILKMTRREQPLVQVQDEDFFFCVGKAAFVHRRKTLWNNLTSHFGKSEEVKVKLEQALEAADIKPSIRGEELTITDFARLADALREVDLK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_PEDPA
Sequence: MAKDFVTGKHTRFGNTRSHALNHSRRSWKPNLQKVRILVDGKPKRVWVSARALKSGKVTRV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: TRPC_MAGMM
Sequence: MDILQKIMQQKAQEVAIRRGQVSEAALLQRVKYAPPTQGFAHALLSRAQQGQNGVIAEVKRGSPSKGRIYPEHLAWQPAQIAESYRANGAACISCLTDETFFMGHDAFLQAIRAAVACPVLRKDFLYHSYQVVEARSLGADAILLIMAVLETPQAQELEAAARELGMDVLVEVHDERELEQAHELKTPLMGVNNRNLKTFVTDIETSFRLAARMEKGRLAISESGLNTPEDLARLNEAGIFSFLIGESLMRGGEPGGALAQLLGREVV
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: 3MGH_RICRS
Sequence: MNKLIPLPREFFARDTNVVSTELIGKTLYFQGKTAIITETESYIGQNDPACHAARGRTKRTDIMFGPAGFSYVYLIYGMYYCLNFVTEAKGFPAATLIRGVHVISPENLYLNGPGKLCKYLGINISHNKCDLINNNEFFVGDIGLKLPYSTTARIGITKGTDKLWRYVVTDITNLISQYNVQP
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: LIRB2_HUMAN
Sequence: MTPIVTVLICLGLSLGPRTRVQTGTIPKPTLWAEPDSVITQGSPVTLSCQGSLEAQEYRLYREKKSASWITRIRPELVKNGQFHIPSITWEHTGRYGCQYYSRARWSELSDPLVLVMTGAYPKPTLSAQPSPVVTSGGRVTLQCESQVAFGGFILCKEGEDEHPQCLNSQPHARGSSRAIFSVGPVSPNRRWSHRCYGYDLNSPYVWSSPSDLLELLVPGVSKKPSLSVQPGPVMAPGESLTLQCVSDVGYDRFVLYKEGERDLRQLPGRQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSECSAPSDPLDILITGQIRGTPFISVQPGPTVASGENVTLLCQSWRQFHTFLLTKAGAADAPLRLRSIHEYPKYQAEFPMSPVTSAHAGTYRCYGSLNSDPYLLSHPSEPLELVVSGPSMGSSPPPTGPISTPGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVVLLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKDTQPEDGVEMDTRAAASEAPQDVTYAQLHSLTLRRKATEPPPSQEREPPAEPSIYATLAIH
What is the function of this protein?
Receptor for class I MHC antigens.  Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042).  Involved in the down-regulation of the immune response and the development of tolerance.  Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647).  Competes with CD8A for binding to class I MHC antigens.  Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).
What are the official names of this protein?
Leukocyte immunoglobulin-like receptor subfamily B member 2, LIR-2, Leukocyte immunoglobulin-like receptor 2, CD85 antigen-like family member D, Immunoglobulin-like transcript 4, ILT-4, Monocyte/macrophage immunoglobulin-like receptor 10, MIR-10.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: KHSE_CAUSK
Sequence: MAVYTDITDDELAAFLGDYDLGQAVAFKGIAEGVENSNFLLETTTGRFILTVYERRAKPEDLPYFLDLLTWLADHGYPSAKPIADRSGATLKTIRGKPAALVEFLPGLSARRPTVAHCREAGEGLAWLHLAGEGYPARRANDLGQPHWASLFSKHRKDAEGLKPGLAATIDKDLAELALAWPRGLPSGVIHADYFPDNVFFKPDGKFAAAIDFYFACDDAYAYDIAVTLNAWCFESDGSFNITAARALIAGYERRRPLSPAERDAIPILARGAAMRFFLTRLADWGSTPAGALVRPKDPLEYERKLAVHREGLSLFGAGA
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: HSP7C_ORYLA
Sequence: MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDHVVQSDMNDWPFNVINDNTRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVNNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGSERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKYKKDISDNKRAVRRLRSACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLDPVEKSLRDAKMDKGQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLNQVYEVGAMTKDNNLLGKFELTGIPPALWCPQIEVTFDIDANGIMNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDDVQRDKVSAKNGLESYAFNMKSTVEDEKLAGKISDEDKQKILDKCNEVISWLDKNQTAERDEYVHQQKELEKVCNPIITKLYQSAGGMPGGCQRECQEVSLELVVLLAVALLDQPLKKLIKHSMTSPSKIFTKKTLFKCNMQSIKSVMRLNQFPFITIT
What is the function of this protein?
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes.  Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation.  This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones.  The affinity for polypeptides is regulated by its nucleotide bound state.  In the ATP-bound form, it has a low affinity for substrate proteins.  However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins.  It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
What are the official names of this protein?
Heat shock cognate 71 kDa protein, Hsc70.1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: METH_MOUSE
Sequence: MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFKDHSRPLKGNNDILSITQPDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEITLQTGVKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVDAYQEQAKGLLDGRVDILLIETIFDTANAKAALFAIQNLFEENYAPPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSDPLCIGLNCSLGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPSTMATHLKDFAVDGLVNIVGGCCGSTPDHIREIAEAVKKCKPRVPPASVFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALSIAKAQVEMGAQVLDINMDDGMLDGPSAMTRFCNSIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEGDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVNVCTRAYHLLVDKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKFGMDMGIVNAGNLPVYDAIHKDLLQLCEDLIWNKDSEATEKLLRYAQTHGTGGKKVIQTDEWRNGSIEERLEYALVKGIEKHIVEDTEEARLNGEKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEARLINGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLACNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLRDDYFEEILEEYEDIRQDHYESLKERKYVPLSQARKHGFHIDWLSEPHPVKPTFIGTQVFEDYNLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYNDAQNMLNILISQKKLQARGVVGFWPAQSVQDDIHLYAEGVVPQAAEPIATFYGLRQQAEKDSSSTDPYHCLSDFIAPLHSGVCDYLGLFAVACFGVEELSKTYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYSRSEQLGVPDLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIEQATGIRLTESLAMAPASAVSGLYFSNVKAKYFAVGKISKDQTEDYALRKNMPVAEVEKWLGPILGYDTD
What is the function of this protein?
Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol.  MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis.  Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate.  The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
What are the official names of this protein?
Methionine synthase, MS, 5-methyltetrahydrofolate--homocysteine methyltransferase, Cobalamin-dependent methionine synthase, Vitamin-B12 dependent methionine synthase.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 dependent methionine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.