PharMolix/UniProtQA huggingface dataset:
Protein: CLU_CAEEL
Sequence: MTLGSETKTDVEVPIINGKHEIPQEENDSGHSSINTPDSSEPDKQVDKFVKITIQPSCGDAFELHLSDNELVQELYQTLLDREATCHRTCFSLYLNGTAVDNYSEVRAIPGFVDGCTLNVVDEPYTIRDARLHLRQVRELLKFGLTEDQHEPPCTNDAQSYLTTINLQPEEKKEPKPSDILPPDHALPGCKERSLAHLLVPQPKELIALKDIAFSPYNPPPGPRKLRGDVLYIDITTVENRIYHVTCCTRGFYVNNSQDGRFDPTVSNSNKTVYQSVIELLQNVSPGFKKVYPQILKRRQEKTLVERLPTSYPVSSWVGNPLKTDGYMSDSLRAIELTEPFRVGFEDHMPGLLRDWNEELQTTFEMTRKSISERVIRDRSYYKIHADYVNAAARGVQSILDGNILAINPGEDKKTHMYIWNNIFFSLGFDVRDHYKELGGDAAAFAATSTDLQGVRAFATLDDPKLNTLGMAIFDYRGYRVTAQSIIPGILEREQEQSVVYGSIDFGKTVVSDEKYHELLEDAAHKLKMLPHTVISEKDGVKEELKLYTSYEAKGIIGNDGRKYVLDLLRSMPPDVHYLDDAEVSEAAKTLGYPRKFPHKLSALRRELIDAFCESRLVTFIQLTAKKIRDLITESKEKNDETLIKQAAEAETELSLLFMAISEDKEFEAKNKVVQDAIKEACAVVHSIYEDRYVMKFNPDCFSSNVKHAPTENLERQRRVVVDAADFLLTQKIPELVQNLKDCVVQPIDGDNLADIMHINGINIRYLGEIGKRLENSVSFARPLVLSDIVARSAKHVIRKINVQITADQLSASTSHILNCLFSVVLDPSPIAANVAKKANKKNGKKRVTSAWSSLTTSALWNSIREDSASYYGYPIEADSLEKFTELHDIQKTALFRRICKVMGVQLVARDYQLDNSTAKKTSIFVEDDIINFFPIIKHHEPFTADAKKMFIRGQQAMSIGASREAYECIGESLNLMTLVYGVMHPDMPQCLRALARLSHVLGETGDALNNQHKAAVMSERLIGLDAGNTIIEYINLAHFAFGALLIPGSLRPLYRARYLMNLVFGEKHPVMAQIDANIGLILFTVQEFDTALKYLQSADAITKTIGEPRKLKTGLISNLIARTHAARGDFRAALVAEKETFAIYSELYGPNHPRVNESSEYLRTLTQQAVTFQKKMLKLDNSTNITELFQAQPPTVTSLFDTLNIINGILIIGVPGLSSLGKQQNGTTEESKTTDVAAQLDNETLD
What is the function of this protein?
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
What are the official names of this protein?
Clustered mitochondria protein homolog.
What is the protein family that this protein belongs to?
Belongs to the CLU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIAA_SALTI
Sequence: MLERIKVCFTESIQTQIAAAEALPDAISRAAMTLVHSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHHSARIQEMHMLTVNCLCGLIDNTLFPHQDD
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: RL32_BORGP
Sequence: MAVPKFKPSKSRSRTRRSINMRKKIPQFQECSNCGNLGVRHRICLKCGYYRNNQYLEIGL
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: GSA_CUPTR
Sequence: MSRNQQLFDRAQQTIPGGVNSPVRAFRSVGGTPRFITRAEGPYMWDADGQRYIDYIGSWGPMIVGHAHPEVVRAVQETAAHSFSFGAPTEAEITMAEEICKLVPSIEQVRLVSSGTEATMSALRLARGFTGRDLIIKFEGCYHGHADSLLVKAGSGLLTFADTTRNAPSSAGVPADVTRHTMVLEYNNVEQLEQAFAKHAGEIAAVIVEPVAGNMNLVRASDAFLQAMRELCTRDGAVLIFDEVMTGFRVALGGAQAHYGIRPDMTCLGKVIGGGMPAAAFGGRRDIMASLAPLGGVYQAGTLSGNPLAVAAGLTTLKLIQAPGFYDRLAAQTRKLADGLAEAARAAGVPFSADAVGGMFGLYFRDGVPASFAEVTQSDTSRFNRFFHAMLDHGVYLAPSAFEAGFVSAQHDDAILDATFDAARKAFAAA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ULAG_ECOLC
Sequence: MSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCVDFWCGTGKQSHGNPLMKQGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHNDHIDVNVAAAVMQNCADDVPFIGPKTCVDLWIGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGVLPDGMDDRAVNYLFKTPGGSLYHSGDSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADMLRMGEALNAKVVIPFHHDIWSNFQADPQEIRVLWEMKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL
What is the function of this protein?
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P.  Is essential for L-ascorbate utilization under anaerobic conditions.
What are the official names of this protein?
Probable L-ascorbate-6-phosphate lactonase UlaG, L-ascorbate utilization protein G.
What is the protein family that this protein belongs to?
Belongs to the UlaG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DADA_ACIAD
Sequence: MRVIVLGSGVIGVASAYYLAQQGAHVTVLDRQTGPAEETSFGNAGQISPGYSTPWAAPGIPFKAVKWMFQHHAPLAINLDGSMWQLQWMAQMLKNCNPQSYSQNKERMMRVAEYSRDCLKSLRETTGISYENRAKGTLQVFRKEAQLEAVQRDIEVLQECGVSYELLYQDDLARVEPALEHAKDKLVGGLHLPNDETGDCYLFTNALAQKAKELGVNFQFNQNVEGLVVEGDEIKGVRVNGQVLKADRYVLAFGSYSRDFLKPLALNLPVYPVKGYSLTIPIVQPEFAPQSTVLDETYKIAITRFDQRIRVGGMAELSGFNLGLNQDRRATLEMVTQDLFPGGNMAEASFWTGLRPMTPDSTPIIGATRFKNLFLNTGHGTLGWTMACGSGKLISDIVLSHQTEISTEGLSLQRYSTAA
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: EXOS5_HUMAN
Sequence: MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALDSDGTLVLDPTSKQEKEARAVLTFALDSVERKLLMSSTKGLYSDTELQQCLAAAQAASQHVFRFYRESLQRRYSKS
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  It seems to be involved in degradation of histone mRNA.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
What are the official names of this protein?
Exosome complex component RRP46, Chronic myelogenous leukemia tumor antigen 28, Exosome component 5, Ribosomal RNA-processing protein 46, p12B.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Nucleus.
Protein: GLYA_LEPIC
Sequence: MQFLPKADPEIFAALKKEDERQENNLEMIASENFVSRAVLEAYTSTLTNKYAEGYPGKRYYNGCHNADVVETLAIERAKKLFGSQYANVQPHSGAQANMAVFLACLEPGDSFLGMNLAHGGHLTHGSPVNVSGKIYKPIPYGVDSKTETINYDEVAKLAREHKPKLIVAGASAYARTIDFSKFAEIAKEVGAKLMADIAHISGLVATGYHPSPIGMFDFVTTTTHKTLRGPRGGLILSTLENEKVLNSRVFPGIQGGPLMHVIAAKAVAFQEALQPDYKKYIETVLANAKTLAEVFVKRGYRVVSGGTDNHLVLLDVSVKGLTGAQAADGLDEVGVTVNKNAIPFDKNPPAVASGIRLGTPALTTRGLKPADMETVGNLICDFLDHPNDDKNRTKVKGGIQEMTQKFPMNQFRLD
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSCL_BREBN
Sequence: MLKEFKEFALKGNVMDLAVGVVIGGAFGKIVTSLVNDIITPLIGLLLGKVDFSGLFINLSGVPYKTIAEAKTAHAATLNYGLFLNSVIDFVIIAFSIFIVIKQLNRFKRKQEVEQAPVTTKECPHCISAIPVKATRCPNCTSMLETKGTALAHE
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIBA_CAMFF
Sequence: MEIIKSNIANLPSRFGKFQIKSYKEGCCKEHLTIFSPNLDVTKTVNVRIHSECLTGDAIGSLKCDCRDQLEASLKYINKHGGMVIYLRQEGRNIGLLNKVNAYALQDNGLDTIEANHQLGFKADERTYEIVDFILKDFGIKSINLLTNNPLKLASLTCVNIEKRIPIEIESNEFNKDYLKVKKEQMGHMLDEFTR
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: NADA_YERE8
Sequence: MSETFDVNAAIYPFPARPVPLDVDQKAFYREKIKTLLKQRDAVLVAHYYTDPEIQALAEETGGCVADSLEMARFGNNHPASTLLVAGVRFMGETAKILNPEKQVLMPTLNAECSLDLGCPADEFAAFCDSHPDRTVVVYANTSAAVKARADWVVTSSIAVELIEHLDSLGEKIIWAPDRHLGNYVQKRSGADVLCWKGACIVHDEFKTQALAQMKALHPDAAVLVHPESPQAVVDMADAVGSTSQLIMAAKTLPQKKLIVATDRGIFYKMQQACPDKELFEAPTAGEGATCRSCAHCPWMAMNGLKAIAEGLEQGGVMHEIHVDEQLRQQALIPLNRMLDFANELKLQTKGNA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGTL1_RHOPB
Sequence: MSVGMAAPRAAFACDPDASRGRLFDELPSKTRSPFRRDCDRVIHSTGFRRLKHKTQVFVYHEGDHYRTRLTHSLEVAQIARAIARQLGLDEDLTEALALAHDLGHPPFGHAGERALDACLQRYGGFDHNAQSLRVVTALEHRYPEFNGLNLTWETLEGIVKHNGPLTDRSGAPLGRYQAHGVPTGIVEFNRCFDLELWSHASLEAQVAGIADDIAYDAHDIDDGLRAGLFGVDDLGEMPLTAQMTAAIDVRYPGLDPARRGAELVRELISFLIGAAVAEAERRLIAAQPASVQAVREAGQDLIMFAPDAAEAEALIKAFLKRHMYRHPRVMRVMDDAETVVFELFARYRDHPADLPAEWLPANAGQGETEADRLRRICNFIAGMTDRYALTEHQRLFDLTPELR
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: STX11_MOUSE
Sequence: MKDRLAELQELSRSYDQQFPDGDNDFDAPREDIVFETDNILESLYRVIQDIQDENQLLLIDVRRLGRQNVRFLTSMRRLSSIKRDTNSIAKAIKTRGEGIHQKLRSMKELSEQAEARHGAHSAVARISHAQYSALARAFQQAMYEYNQAEMKQRDNCKIRIQRQLEIMGKDMSGEQIEDMFEQGKWDVFSENLLADLKGARAALNEIESRHRELLRLEGRIRDVHELFLQMAVLVEKQEDTLNVIELNVQKTLDYTGEAKAQVRKAVQYKKKNPCRTICCFCCPCVN
What is the function of this protein?
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
What are the official names of this protein?
Syntaxin-11.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Protein: MSRA_MYCSJ
Sequence: MSDHKKAILAGGCFWGMQDLIRKQPGVVSTRVGYTGGQNDHPTYRNHPGHAESIEITYDPAQTDYRALLEFFFQIHDPTTKNRQGNDVGTSYRSAIFYVDDDQKRVALDTIADVDASGLWPGKVVTEVTPAGEFWEAEPEHQDYLERMPWGYTCHFPRPDWKLPKRADAKA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: Y06N_BPT4
Sequence: MQKPKLNKVKYSFSESFLIFAVALAAALTGSLIGLLIDCFILKISGTVDIIEVWSELCYTKIISLFSFFGIILYFHYDNFKINWQRKKDYKIQLKEYNSYMSYIENESMKEFVIDCRKIK
What are the official names of this protein?
Uncharacterized 14.2 kDa protein in e-segB intergenic region.
Protein: PMRA_STRR6
Sequence: MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSQQVAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYWLIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAELFGIRTVFLLVGSFLFLAAILTICFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLFLTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDKVGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPKAGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYHAVFYATSLCVAFSCLFNLIQFRTLLKVKEI
What is the function of this protein?
Efflux pump for various substrates.
What are the official names of this protein?
Multi-drug resistance efflux pump PmrA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MSP1_PLAYO
Sequence: MKVIGLLFSFVFFAIKCKSETIEVYNDLIQKLEKLESLSVDGLELFQKSQVIINATQPTETIDPFTNHNFAQQVQDFVTKFEGLGFTEQTELVNLIKALTPNRYGVKYLIESKEEFNGLMHAINFYYDVLRDKLNDMCANNYCEIPEHLKISEEETEMLKKVILGYRKPIENIQDDIEKLEIYIERNKETVAALNALIAEETKKIQPEGNEDCNDASCDSDKYNKKKPIYQAMYNVIFYKKQLAEIQKVVEVLEKRVSTLKKNDAIKPLWQQIEVLNAAPVVTAETQIVTGGQSSTEPGSGGSSASGTSSSGQASAGTGVEQANTVASVTVTPSVGQNGEASTNPQTAQVQPVPTLTLEEKQKKIAGLYAQIKEIAKTIKFNLEGIFVDPIELEYFKKEKKKESCNLSTSSCKKNKASETIIPLTIRYPNGISYPLPENDVYNKIANNAAETTYGDLTHPDNTPLTGDLATNEQARKDLIKAIKKKIKAEEKKLETLKTNYDNKLTEFNQQKTPFKEAAKEFYESKFRNKLTSEIFEKFKTKRDEYMTKKTELNTCEYGNTKELINKLNKQLNYLQDYSLRKDIISNEIEYFSNKKKELQYNINRLAEAVQAKQNVLVASKDVPLSTLVELQIQKSLLTKQIEQLNKTEVSLNKAQLKDKLYVPKTYGNEGKPEPYYLIAVKKEVDRLAQFIPKIESMIAKEKERMEQGPAITGESEEVPSGPSAESSTDRSTQSSTSSSSSSSSTPAAAESSSATLPEAPAPAEAASPSTEASEETTIPPTTQETQPSQAASSTTPAKPVMTKLYYLEKLQKFLVFSYSCHKYVLLQNSTINKDALSKYALTSEEDKIRTLKRCSELDVLLAIQNNMPTMYSLYESIVDGLQNIYTELYEKEMMYHIYKLKDENPSIKSLLVKAGVIEPEPVAAPTPVTPAATEQQQQQATPDVQSDAPAPSDVSQQPETPVTSTTPEVTTSTEASSSAPGEGTPSGEAGASGTEGATASNAATPAGTSASGSAASNASTTSDVTPPAAAAAVPSTSTPAPAQPPAANSQSGNPDSGIRSRAESEEDMPADDFELDNLYKSYLQQIDGNNTEFINFIKSKKELIKALTPEKVNQLYLEIAHLKELSEHYYDRYSTYKLKLERLYNKHEQIQLTNRQIRDLSILKARLLKRKQTLNGVFYILNGYVNFFNKRREAEKQYVDNALKNTDMLLKYYKARTKYFTSEAVPLKTLSKASLDRESNYLKIEKFRAYSRLELRLKKNINLGKERISYVSGGLHHVFEEFKELIKDKDYTGKKNPDNAPEVTNAFEQYKELLPKGVTVSTPAVAVTTTLAADAPATPEGAVPGAVPGAVPGAVPGAVPGAVPGSGTDTRVAGSSVDDNEDDDIYQIASGQSEDAPEKDILSEFTNESLYVYTKRLGSTYKSLKKHMLREFSTIKEDMTNGLNNKSQKRNDFLEVLSHELDLFKDLSTNKYVIRNPYQLLDNDKKDKQIVNLKYATKGINEDIETTTDGIKFFNKMVELYNTQLAAVKEQIATIEAETNDTNKEEKKKYIPILEDLKGLYETVIGQAEEYSEELQNRLDNYKNEKAEFEILTKNLEKYIQIDEKLDEFVEHAENNKHIASIALNNLNKSGLVGEGESKKILAKMLNMDGMDLLGVDPKHVCVDTRDIPKNAGCFRDDNGTEEWRCLLGYKKGEGNTCVENNNPTCDINNGGCDPTASCQNAESTENSKKIICTCKEPTPNAYYEGVFCSSSSFMGLSILLIITLIVFNIF
What are the official names of this protein?
Merozoite surface protein 1, 230 kDa merozoite surface antigen, Py230, Merozoite surface antigens, PMMSA.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: PRVM_CHICK
Sequence: AMTDVLSAEDIKKAVGAFSAAESFNYKKFFEMVGLKKKSPEDVKKVFHILDKDRSGFIEEEELKFVLKGFTPDGRDLSDKETKALLAAGDKDGDGKIGADEFATMVAES
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions (By similarity).
What are the official names of this protein?
Parvalbumin, muscle.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: DCEB_ECOLI
Sequence: MDKKQVTDLRSELLDSRFGAKSISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT
What is the function of this protein?
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction.  The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions.  The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
What are the official names of this protein?
Glutamate decarboxylase beta, GAD-beta.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Note=Localized exclusively in the cytoplasm at neutral pH, but is recruited to the membrane when the pH falls.
Protein: PRPB_VIBCH
Sequence: MPNNKVKENPMSLSPGAKFRLAVKTHHPLQIVGTINPYCAMMAKSIGHQAIYLSGGGIANASYGLPDLGITTLNDVLVDVERITNACDLPLLVDIDTGFGGAFNIARTIKAMEKAGAAAVHMEDQVAQKRCGHRPNKAIVSQQEMVDRVKAAVDARINPEFVIMARTDALAVEGMDSAIERAIACVEAGADMIFPEAMTELKQYEQFSTALRSATGKPVPILANITEFGQTPLYSGEQLAAVNVDMVLYPLSAFRAMNKAAENVYRHLLEHGNQEALLDQMQTRKELYAYLHYHEYEDKLDQLFSQPS
What is the function of this protein?
Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route).  Catalyzes the thermodynamically favored C-C bond cleavage reaction of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
What are the official names of this protein?
2-methylisocitrate lyase, 2-MIC, MICL, (2R,3S)-2-methylisocitrate lyase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
Protein: ACCD_HAHCH
Sequence: MSNWLEKIIPGMGGAQSKHKSNVPEGLWKKCPKCSAVLYRPELEKNLDVCPKCQHHMRISARRRIDIFLDGADRMEIAPELEPADRLKFKDTKRYKDRLVSNQKATGEKDALVAFKGTVAGVPVVAVAFEFNFLGGSMGAVVGEKFVRAVNVCLEENRALICFSASGGARMQEALISLMQMAKTAAALEVMKQRGLPYISVMTDPVFGGVSASLAMLGDLNVAEPNALIGFAGPRVIEQTVREKLPEGFQRSEFLLEHGALDMILSRNQLRRRLSMLISKMMKLPEPEFENEEELEEEEMERPEPPDNVE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2G_METTH
Sequence: MKNQSEINIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKCPQCEAPMCYTTAEICERCGTETELLRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERALESYREIKEFVKGTCAEDAPIIPVSAQQGANIDILIETIEERIKTPKRDVDKPARMYVARSFDINKPGADPEHLAGGVIGGSLVQGRLRVGDEIEIRPGIQVKKDGKQTWMSLHSTITGLVAGGEEMEEVGPGGLVGVGTLLDPALTKADSLSGSVAGEPGTLPPVRHSFTMETHLLERVVGTKEETKVEPIKTGEPLMINVGTTTTVGVVKSARADDADVVLKLPACAEEGQRIALSRRVGARWRLIGYGIIK
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit gamma, aIF2-gamma, eIF-2-gamma.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: DBP3_PHANO
Sequence: MGKRPIEDDAVASSELSRKKSKKEKSGKSKKSVIGEGADTNGHAPAAETTVDGSENEALSKAERKAAKKAKKEAKEASKAGKADAPTVENDEEAAKAARKAARKAEKKKLKEAEKTASSAPTEASSVPAQTLSSSNAGSYTEHTELAQLPQSEIDAFLTKNTMTIEDPKPAARKLRPIVNFKYLPVTDESQRAPFAGFTAPTPIQAATWPFLLSGRDMVGVAETGSGKTLAFGVPCVRAILSLPKDKRKGIKAVIVSPTRELAVQIYDQLVALAHPAGLSVVCVYGGVPKDPQVAACRKAHIVVATPGRLNDLIGDGSADLSNADYVVLDEADRMLDKGFEEPIRQIISQTPKKRQTLMFTATWPPSVRDLASTFMVSPVRITIGDNQSGELRANVRIKQLVEVLDPHAKEQRLLQLLKQYQSGKNKDDRILVFCLYKKEAMRIENFIRMKGFRVGGIHGDLSQEKRSASLAAFKEGQVPLLVATDVAARGLDIPAVKLVINVTFPLTAEDYVHRIGRTGRAGKEGLAITFFTEHDKGLSGSLINVLKAANQEVPEELLKFGTTVKKKEHGAYGAFYKDVDNTKAATKITFD
What is the function of this protein?
ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis.  Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GPI10_ASPOR
Sequence: MSTSSRRRRSPLELSSSRSSSSSSSSYASWASTTSPSTSTSTPPSLSRTTTVSTSHVFLFLLAFRLLNALSLRTFFQPDEFFQSLEPAWQTAFGETHGANGDTICGLPSILCYLLQFILSPTLPRALFVSPPHSAILSAIGDLYTWKLARYVYGRRSHEAWAALALTVLSPWQWFCSTRTLSNCLETTITIVALNLWPWEWSSESTPTVQPRRNTRSTTRDTGLDNTGDGAVVVRLRKCLTLAALACILRPTNILIWMGLAGVAWFRSAWRERTILCREVLLCGVSVLTGSVVLDRLYYGLWTFPPLKFLYFNIAQSLAVYYGRNDWHYYATQGYPLLLTTALPFTLVGLYRTLSQSQSTINTRNVSVQTQLAAICLLMPLVLSLISHKEVRFIYPLLPSLHVLTAPPLVDFFLPAVSRSNGAYMPRRLSLVFLLLVNITVAIYTSVYHASGTLNVLSYLRDQQQAHTTVDKSAYSPGSSQRITAGFLMPCHSTPWRSHLVDPNIHAWALSCEPPVDLTEPQKAVYVDEADQFYNDPSQFLRENMVGGLRHLPRKPSYLASSKSLEASPQAYQQATPHEWPDYLIFFAQLEPTLHSFLRSSSYGECWRTWNTAWHDDSRRRGDIIVWCLDPTEQAAWRSATRKRTLEHRDHQFDRIVETLRKNAPAEILPLDSMDILSVRAIGLLNLVLVLALGTTQTVLVRNPVTSLEEVLMDPSDMDLAKIFQEEN
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 3, GPI mannosyltransferase III, GPI-MT-III, Glycosylphosphatidylinositol-anchor biosynthesis protein 10.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 22 family. PIGB subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DAPD_MYCTO
Sequence: MSTVTGAAGIGLATLAADGSVLDTWFPAPELTESGTSATSRLAVSDVPVELAALIGRDDDRRTETIAVRTVIGSLDDVAADPYDAYLRLHLLSHRLVAPHGLNAGGLFGVLTNVVWTNHGPCAIDGFEAVRARLRRRGPVTVYGVDKFPRMVDYVVPTGVRIADADRVRLGAHLAPGTTVMHEGFVNYNAGTLGASMVEGRISAGVVVGDGSDVGGGASIMGTLSGGGTHVISIGKRCLLGANSGLGISLGDDCVVEAGLYVTAGTRVTMPDSNSVKARELSGSSNLLFRRNSVSGAVEVLARDGQGIALNEDLHAN
What is the function of this protein?
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUN7_ARATH
Sequence: MHPGNVWGGSLDAVDSDRIAAEEEERLRNTTEWDRGAIHSQRSELDETQQGWLLAPQDNWRKKKKKYVNLGCVSVSRTVFLWTVGSIAVLFLVVALPIIIVKSLPRHKSAPPPPDNYTLALHKALQFFDAQKSGKLPKKNKVSWRGDSGTKDGLPDVVGGLVGGYYDGGSNVKFHFPMAFSMTMLSWSLIEYSHKYKAIDEYDHMRDVLKWGTDYLLLTFNNSATRLDHIYTQVGGGLRDSESPDDIYCWQKPEDMSYDRPVLSSTSAADLGAEVSAALAAASIVFTDKPDYAKKLKKGAETLYPFFRSKSRRKRYSDGQPTAQAFYNSTSMFDEFMWAGAWLYYATGNKTYIQFATTPSVPQTAKAFANRPELMVPSWNNKLPGAMLLMTRYRLFLNPGFPYENMLNRYHNATGITMCAYLKQYNVFNRTSGGLMQLNLGKPRPLEYVAHASFLASLFADYLNSTGVPGWYCGPTFVENHVLKDFAQSQIDYILGDNPLKMSYVVGFGKKFPRRVHHRGATIPNDKKRRSCREGLKYRDTKNPNPNNITGAMVGGPNKFDEFHDLRNNYNASEPTLSGNAGLVAALVSLTSSGGQQIDKNTMFNSVPPLYSPTPPPPKAWKP
What are the official names of this protein?
Endoglucanase 7, Endo-1,4-beta glucanase 7.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 9 (cellulase E) family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.