PharMolix/UniProtQA huggingface dataset:
Protein: OVOL2_HUMAN
Sequence: MPKVFLVKRRSLGVSVRSWDELPDEKRADTYIPVGLGRLLHDPPEDCRSDGGSSSGSGSSSAGEPGGAESSSSPHAPESETPEPGDAEGPDGHLATKQRPVARSKIKFTTGTCSDSVVHSCDLCGKGFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFDLKRHVRTHTGIRPYKCNVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDCGYTGPTQEDLYLHVNSAHPGSSFLKKTSKKLAALLQGKLTSAHQENTSLSEEEERK
What is the function of this protein?
Zinc-finger transcription repressor factor (PubMed:19700410).  Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity).  Positively regulates neuronal differentiation (By similarity).  Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410).  Important for the correct development of primordial germ cells in embryos (By similarity).  Plays dual functions in thermogenesis and adipogenesis to maintain energy balance.  Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes.  In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (By similarity).
What are the official names of this protein?
Transcription factor Ovo-like 2, hOvo2, Zinc finger protein 339.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMG_CORJK
Sequence: MAKQDDASIQSPDIGEPPAAAREVFGDRLRLACDYAEFLATAGIERGLLGPREVPRIWERHILNSAVLGEVIDEGCRVVDIGSGAGLPGIPLAIARPDLKVQLLEPLLRRYNFLAEVNSQLNLGCEVVRGRAEDPAVVEALGGADVATSRAVAPLGKLTRWSLPLVKVGGAMKALKGGSVAEELERDAKEIAKAGGGDGTIELVGESKVAEPTHVITIPRIR
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_SHIB3
Sequence: MGQKVHPNGIRLGIVKPWNSTWFANTKEFADNLDSDFKVRQYLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSITSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEKPAAQPKKQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: GPDA_LACAC
Sequence: MTKIAVLGNGSWGSVLGSMLADNGNDVVLYGNIESVNDEINATHTNSHYMKDWKLNENTRATGDLEDALDGAEVVLFVLPTKAVRIVAKNVREILDKSGAKPLLVTATKGIEPGTKKLISEILTDEIYPNDEDKIVAISGPSHAENVAQKDLTAIACASTNEENAKKVQKLFSNDYVRFYTNDDLVGVEVGGAVKNVIAIAAGILVGQGYGDDAKAALMTRGLAEITRLGVNYFGAKPMTFSGLSGIGDLIVTCTSVNSRNWRAGKQIGEGKSLDYVLKNMGQVVEGATTVKAVHELCEEKNIDMPISEAIYRVLYEGTDVETEIKKMMGRAPKPEIRL
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_STAAB
Sequence: MTKLFIPYIMGDKDLIENATLLSENGADIIEIGVPFSDPVADGPVIMEAGQQAIKQGITIDYIFEQLEKHGNQIKCQYVLMTYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPFELSQRLKQQFSHYGVKIISLVAMTTDDKRIKEIVSHAEGFIYTVTMNATTGQNGAFHPELKRKIESIKAIANVPVVAGFGIRTPQHVADIKEVADGIVIGSEIVKRFKSNTREEIIKYLQSIQQTLNN
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: PP359_ARATH
Sequence: MLRRLLKPNLVVTLRKLSSSSASYVDRHISVILCDQSLSLESLRKHNALIITGGLSENIFVASKLISSYASYGKPNLSSRVFHLVTRRDIFLWNSIIKAHFSNGDYARSLCFFFSMLLSGQSPDHFTAPMVVSACAELLWFHVGTFVHGLVLKHGGFDRNTAVGASFVYFYSKCGFLQDACLVFDEMPDRDVVAWTAIISGHVQNGESEGGLGYLCKMHSAGSDVDKPNPRTLECGFQACSNLGALKEGRCLHGFAVKNGLASSKFVQSSMFSFYSKSGNPSEAYLSFRELGDEDMFSWTSIIASLARSGDMEESFDMFWEMQNKGMHPDGVVISCLINELGKMMLVPQGKAFHGFVIRHCFSLDSTVCNSLLSMYCKFELLSVAEKLFCRISEEGNKEAWNTMLKGYGKMKCHVKCIELFRKIQNLGIEIDSASATSVISSCSHIGAVLLGKSLHCYVVKTSLDLTISVVNSLIDLYGKMGDLTVAWRMFCEADTNVITWNAMIASYVHCEQSEKAIALFDRMVSENFKPSSITLVTLLMACVNTGSLERGQMIHRYITETEHEMNLSLSAALIDMYAKCGHLEKSRELFDAGNQKDAVCWNVMISGYGMHGDVESAIALFDQMEESDVKPTGPTFLALLSACTHAGLVEQGKKLFLKMHQYDVKPNLKHYSCLVDLLSRSGNLEEAESTVMSMPFSPDGVIWGTLLSSCMTHGEFEMGIRMAERAVASDPQNDGYYIMLANMYSAAGKWEEAERAREMMRESGVGKRAGHSVV
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At4g39952, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: AMPN_LACDL
Sequence: MAVKRFYETFHPDHYDLYIDVDRAARSFSGTSTIHGEIQEETVLVHQKYMTISKVTVDGKEVPFTFGDDFEGIKIEAGKTGEAVIAIDYSAPLTDTMMGIYPSYYQVDGVKKELIGTQFETTFAREAFPCVDEPEAKATFSLALKFDEHEGETVLANMPEDRVENGVHYFKETVRMSSYLVAFAFGEMRSLTTHTKSGVLIGVYSTQAHTEKELTFSLDIAKRAIEFYEDFYQTPYPLPQSLQLALPDFSAGAMENWGLVTYREAYLLLDPDNTTLEMKKLVATVVTHELAHQWFGDLVTMEWWDNLWLNESFANMMEYLSVDHLEPNWHIWEMFQTSEAAAALTRDATDGVQSVHVEVNDPAEIDALFDGAIVYAKGSRMLVMVRSLLGDEALRKGLKRYFDKHKFGNAAGDDLWDALSTATDLNIGEIMHTWLDQPGYPVVNAFVEDGHLKLTQKQFFIGEGKEVGRKWEIPLNANFKAPKIMSDVELDLGDYQALRAEAGHALRLNVGNNSHFIVKYDQTLMDDIMKEAKDLDPVSQLQLLQDLRLLAEGKQASYADVVPVLELFKNSESHIVNDALYTTADKLRQFAPAGSEADKNLRALYNDLSKDQVARLGWLPKAGESDEDIQTRPYVLSASLYGRNADSEKQAHEIYVEYADKLAELSADIRPYVLINEVENYGSSELTDKLIGLYQATSDPSFKMDLEAAIVKSKDEGELKKIVSWFKNAEIVKPQDLRGWFSGVLSNPAGEQLAWDWIRDEWAWLEKTVGGDMEFATFITVISRVFKTKERYDEYNAFFTDKESNMLLNREIKMDRKVIANRVDLIASEQADVNAAVAAALQK
What is the function of this protein?
Aminopeptidase with broad substrate specificity to several peptides.
What are the official names of this protein?
Aminopeptidase N, Alanine aminopeptidase, Lysyl aminopeptidase, Lys-AP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=It may be secreted through an unknown mechanism.
Protein: HSLU_IDILO
Sequence: MSEMTPREIVDELNRHIIGQDKAKRAVAVALRNRWRRMQLDDELRQEVTPKNILMIGPTGVGKTEIARRLAKLARAPFIKVEATKFTEVGYVGKEIESIIKDLTDVAVKQTREEMMQKVRYRAEEAAEERILDVLLPPAKTSSSGWAQQQEETPENDDQRGTRQVFRKKLREGQLDDKEIEIDLAMPQMGVEIMAPPGMEEMTSQLQNMFQNMGSDKTKARKMRIKDAYKQLVDEEAAKLLNPDDVKEAAIESVEQNGIVFLDEIDKICKRGDTSGPDVSREGVQRDLLPLVEGTTVNTKHGMIKTDHILFIASGAFQMSKPSDLIPELQGRLPIRVELEALTSGDFVRILTEPSASLTTQYHALLNTEGVEVSFTEEGIQRIAEVAFHVNETTENIGARRLHTVLERLMEEISFHATDHSGEKLVIDADYVNEHVGELSQDEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCAT2_MOUSE
Sequence: MNRCAEAAAVAATVPGSGVGDAGLRPPMVPRQASFFPPPVPNPFVQQTTISASRRLQMFLLGIILLPVRALLVGIILLLAWPFAVISTACCPEKLTHPISNWRRKITRPALTFLARAMFFSMGFTVTVKGKVASPLEAPIFVVAPHSTFFDGIACVVAGLPSLVSRNENAQTPLVGRLLRALQPVLVSRVDPDSRKNTINEIKKRATSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFLQLCVLTFCQLFTKVEIEFMPVQAPSEEEKNDPVLFASRIRNLMAEALEIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFSKISRKLKLDWDGIRKHLDEYASIASSSKGGRIGIEEFAEYLKLPVSDVLRQLFALFDRNNDGSIDFREYVIGLAVLCNPANTEEIIQVAFKLFDVDEDGYITEEEFCTILQASLGVPDLNVSGLFREIAQRDSVSYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPEEVQTAPSVASNKVSPESQEEGTSDKKVD
What is the function of this protein?
Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:18156367, PubMed:18285344).  Activity is calcium-dependent (PubMed:17182612).  Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:17182612, PubMed:18156367).  Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity).  Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612, PubMed:18285344).  Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (PubMed:17182612).  Under resting conditions, acyltransferase activity is preferred (PubMed:17182612).  Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (PubMed:17182612).  Involved in the regulation of lipid droplet number and size (By similarity).
What are the official names of this protein?
Lysophosphatidylcholine acyltransferase 2, LPC acyltransferase 2, LPCAT-2, LysoPC acyltransferase 2, 1-acylglycerol-3-phosphate O-acyltransferase 11, 1-AGP acyltransferase 11, 1-AGPAT 11, 1-acylglycerophosphocholine O-acyltransferase, 1-alkenylglycerophosphocholine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, Acetyl-CoA:lyso-platelet-activating factor acetyltransferase, Acetyl-CoA:lyso-PAF acetyltransferase, Lyso-PAF acetyltransferase, LysoPAFAT, Acyltransferase-like 1.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Lipid droplet.
Protein: SEC31_LODEL
Sequence: MVKIGEINRTSTFAWSLDALPLLATGTVAGAVDINFTSSATLEIWEIFSPTKKNEPIFTASVEHKFYALAWSKPFENRPKGLIAGAFEDGTVEFWDADVLIKSKNLKKASVHKSTKHSGGAVKSLQFNPIQHHVLVTGGSNGQIFVWDTKTFGEPFSPGQAMTPMDEISCVAWNNSVSHILASTGNSGYTSIWDLKSKKEVLHLSYTGATGKANFSHVAWHPTKSTKLVTASDSESCPVILTWDLRNSNAPEKVMEGHKKGVLSLDWCKQDPELLISSGKDNATILWNPIEGKKLGEYPTTANWAFKTRFAPSAPDIFATASFDGKIIVQTIQDTSPPVSTKVSASHDDNEFWSELSVTETQQPVFEVKQAPIWLKNPVSVSFGFGSKLVVVGKDANGKSTLKVTKFLVKGHERAENLLKHLKSENYDAIVDYHLQGPAINEQDKSDWEVLKSLSKNGKQGLFDDEEDGSDTTEEKKNSANKEDADADATTKDKDIENGKDGKDDTANAANDGDGDDDFFAHLGNGSTRQTVETYSPSGDFDIYNSQTSKSDKKLTKLILKNKIDDAVDSCLEQDNLLEALVLALDSSAQVKEKVKNAYFSKHKESSLARVIYNATEKNVTDLVAHANVKNWKDIALGISAFATDSEEYSSKISELGDRILHHDKSARDEAITCYIAGGALDKIANLWLQELPQYEADLLKTDDKNISSPSEARLQALTSFVEKIETFKYYAKLGSVLSGPLVEPISKTILEFVNLISGAGEFELANKLLMLLPGDIAGVEKERISKATGKDTKPIVSEGSAARASVSSSKYSKIPRKSLTSANANANANANVNSNASSTGALPTPATNILPPLANHHIQGQTPSFVQPQPQTAFGQLPTPSTSSAYPTAPVAKSNPYAKPNPYTPNNIYKTSPVPQPSVAPQASFSGTAPPPPPAVQKANSKERMERLARNI
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC31.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC31 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YBIS_ECOL6
Sequence: MNMKLKTLFAAAFAVVGFCSTASAVTYPLPTDGSRLVGQNQVITIPEGNTQPLEYFAAEYQMGLSNMMEANPGVDTFLPKGGTVLNIPQQLILPDTVHEGIVINSAEMRLYYYPKGTNTVIVLPIGIGQLGKDTPINWTTKVERKKAGPTWTPTAKMHAEYRAAGEPLPAVVPAGPDNPMGLYALYIGRLYAIHGTNANFGIGLRVSHGCVRLRNEDIKFLFEKVPVGTRVQFIDEPVKATTEPDGSRYIEVHNPLSTTEAQFEGQEIVPITLTKSVQTVTGQPDVDQVVLDEAIKNRSGMPVRLN
What is the function of this protein?
Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp) to the peptidoglycan via a meso-diaminopimelyl-L-Lys- bond on the terminal residue of Lpp.
What are the official names of this protein?
Probable L,D-transpeptidase YbiS.
What is the protein family that this protein belongs to?
Belongs to the YkuD family.
What are the subcellular locations of this protein?
Periplasm.
Protein: EX7L_CAMFF
Sequence: MTVSELNEQAKALLETHFSFVEVTGEISRLIRHSSGHWYFSLKDEKSVISSAMYKFSNQQVKFEVKDGMQVTIYGKLTIYPPSGSYQLLANKMLPVGIGELELAFNQLKSKLENEGLFDIKFKKPLPKFPKKIAIVTSLTSAAYQDMLKVINSRYKLCEFIAFNTLVQGEMAAANIIQMLQKADKMGFDAIVLARGGGSKEDLWCFNDENLARVIFTLKTPIVSAVGHEIDYCISDFVSDHRSLTPTAAMVDLLPDANTILQSLDIAFDKFESFIDGKFQNSFNILNLINQSLKNQAISQKIEKANLTLENKKANLENLITSKINNLAHKIKEFELVFDRQEQFFKATKNMVQIEKNGKIMPLHELQIGDEISIYSQITKKNAIIKS
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMD5_YEAST
Sequence: MSELLDSFETEFAKFYTDSNLEETNLQKCLDHTHEFKSQLKKLKAHLNKHIQESKPEVYNKLSDKEKQKFKRKRELIIEKLSKSQRQWDHSVKKQIKYVSQQSNRFNKSTLNKLKEFDIDSVYVNKLPKETMENVNEAIGYHILRYSIDNMPLGNKNEAFQYLKDVYGITNKESTEFIEMGQIVHDLKKGDTESCLKWCSNEMESLSSNHTALSSLKFDLYTLSAMQIVKHGNPVELYYQITQNAPLDCFRHREKELMQNVVPLLTKSLIGQPIEDIDSKVNKELKECTSLFIKEYCAAKHIFFDSPLFLIVLSGLISFQFFIKYKTIRELAHVDWTTKDELPFDVKLPDFLTHFHPIFICPVLKEETTTENPPYSLACHHIISKKALDRLSKNGTITFKCPYCPVNTSMSSTKKVRFVML
What is the function of this protein?
E3 ubiquitin-protein ligase component of the GID complex (PubMed:12686616, PubMed:18508925).  Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:9737955, PubMed:18508925).  Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:9737955, PubMed:12686616, PubMed:18508925, PubMed:28126757).
What are the official names of this protein?
E3 ubiquitin-protein ligase RMD5, Glucose-induced degradation protein 2, Required for meiotic nuclear division protein 5, Sporulation protein RMD5.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1882_BART1
Sequence: MCKIMHKTIPKKQRQKSFYRGVRAEKLAAWWLRFKGFHIAEMRFKTKCGEIDLIARRGNLVLIVEVKARSTLLEAMEAVSRMNEKRIEAAADIWLARQKDYALLSVRFDLIAILPWRWPKHIPAFFTSDR
What are the official names of this protein?
UPF0102 protein BT_1882.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RS3A_VANPO
Sequence: MAVGKNKRLSKGKKGLKKKVVDPFTRKEWFDIKAPSTFENRNVGKTLVNKSTGLKNAADALKGRVVEVCLADLQGSEDHSFRKIKLRVDEVQGKNLLTNFHGMDFTTDKVRSMVRKWQTLIEANVTVKTSDDYVLRVFAIAFTRKQSNQVKRTSYAQSSHIRAIRKVISEILTREVQGSTLAQLTSKLIPEVINKEIENATKDIFPLQNVHIRKVKLLKQPKFDLGSLMALHGEGSGEEKGKKVSGFKDEVLETV
What are the official names of this protein?
40S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COF_ECO5E
Sequence: MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGAISLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLHEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: GCH4_BURM9
Sequence: MNLMNPEFAMPDVQSTVDTRQMPIQRVGVRAVRHPLTVRTAEGETQATVGTWNLDVHLPADQKGTHMSRFVALLEERGGPLTADAFRTMLATMLEKLEARAGRIEVSFPYFVNKTAPVSGVRSLLDYEVTLTGDVRDGLTRVFAKVLVPVTSLCPCSKKISQYGAHNQRSHVTIDAELAADVPVEDLIRIAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDVARRLDADERIVAYVLEAENFESIHNHSAYALIERDKRRGA
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: TTYH1_BOVIN
Sequence: MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSAFAPQEREYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWNCIAALLVGCAGIGVGFYGNSETSDGVSQLSSALLHANHTLTAIDHLVLEMVERLNEAVRTELTTLEEVLTQRTELVAAARGARRQAETVAQQLQGLAFWRGVPLSPLQVAEDVSFVEEYRWLAYVLLLLLELLVCLFTLLGLARQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSSPDSYILNLTQEETGLGSDILNYYFLCNQAVSNPFQQRLTLSQRALANIHSQLQGLEREAVPQFPSAQKPVLSLEETLNVTEGNFHQLVALLHCRGLHKDYGSALRGLCEDTLEGLLFLLLFSLLSAGALATVLCSLPRAWALFPPSDDYEDTDDDDPFNPQESKRFVQWQSSI
What is the function of this protein?
Probable chloride channel.  May be involved in cell adhesion (By similarity).
What are the official names of this protein?
Protein tweety homolog 1.
What is the protein family that this protein belongs to?
Belongs to the tweety family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ERPA_ACIBY
Sequence: MNAQALVLTDNAANKVRQLRDSEGNDDLMLRVYVTGGGCSGFSYGFNFAESVNEDDAEFVNGDVKMLVDSLSYQYLVGSVVDYVEGLEGSRFIVQNPNATTTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: ATPB_HAEIE
Sequence: MSAGKIVQIIGAVIDVEFPQDAVPKVYDALKVESGLTLEVQQQLGGGVVRCIALGTSDGLKRGLKVENTNNPIQVPVGTKTLGRIMNVLGEPIDEQGAIGEEERWAIHRSAPSYEEQSNSTELLETGIKVIDLICPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMKDSNVLDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLFFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDSTVVLSRQIASLGIYPAVDPLDSTSRQLDPLVVGQEHYDVARGVQGILQRYKELKDIIAILGMDELSEEDKLVVARARKIERFLSQPFFVAEVFTGSPGKYVTLKDTIRGFKGILEGEYDHIPEQAFYMVGSIDEVLEKAKNM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GMHA_CHRSD
Sequence: MDFQSRILGHFNASIDAKTYASEVLPPFIEVASQMMVQCLVSEGKILACGNGGSAGDSQHFSSELLNRFERERPSLPALALTTDTSTLTSIANDYSYNEIFSKQIRALGQPGDILLAISTSGNSANVVQAIQAAHDRDMHIVALTGRDGGDMASLLGQDDCEIRVPSTSTARIQEVHLLAIHCLCDLIDQQLFGSTE
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED15_MOUSE
Sequence: MDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPTPGAAGIGMPPRGPGQSLGGMGGLGAMGQPLPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQQQQHLIKLHHQSQQQQIQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPSMQQPQPPPSQALPQQLSQLHHPQHHQPPPQAQQSPIAQNQPPQIPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQPQAAVQAAQSAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSISLGGQPTTQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIVSPVVCSRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPMWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  Required for cholesterol-dependent gene regulation.  Positively regulates the Nodal signaling pathway (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 15, Mediator complex subunit 15, Positive cofactor 2 glutamine/Q-rich-associated protein, PC2 glutamine/Q-rich-associated protein, mPcqap.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 15 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: UVRB_MESM1
Sequence: MENKGFELVSTYKPTGDQPRAIQELIEGLEQNKKSQVLLGVTGSGKTFTIANVIKAANRPVLLLSHNKTLASQLYSELKDFFPNNRVEYFVSYFDYYRPEAYMPNTDTYIDKTTKSNWDLEEMRMSTLNSISTKRDTIVVASVASIYGALKPKEYWSAFYNISIAQKISRKEFLLDLVQRGYKRNNVASEPGSFNAKGDFVDIIPAWTKGFHIRVEFFGDEIEKISTIDSNNKITIEKFKEYLIFPASAYTAPTGTIEAAVLRIREELHQRLEYFEKEGKLLEKQRLEDRTRNDLESLEEFGFCPGIENYSRHVDGRAEGEQPFTLFDYLPNDALLIIDESHMMIPQLNGMYNGDRARKLNLVNYGFRLPSALDNRPLQFHEFEKYEFQKIYISATPSDYEINQAHGEIVKQIIRPTGLLDPLIEIRREQNQVEDMFDEIQKQKAKKQRTLILATTKKVSEELTRYFQEKKEKVAYIHSDYTTFERNEILRKLRKGVYDTVIGINLLREGIDLPEVSLIMVLDANKESFFRSKKSLIQIVGRAARNVNGRVIFYANNISKSMEETIYDNLDKRKIQMDYNKKHNIIPKTIIKPITEAIEDKKLNESLISFMSHSKTKKSIKEKEALVKDLRNQMLDASKQLNFERAAELRDIILELEAN
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.