PharMolix/UniProtQA huggingface dataset:
Protein: FND10_MOUSE
Sequence: MRAPPLLLLLAACAPPSGAAVDPTPPGWEPAPDAPWCPYKVLSEGPETGGGRLCFRSPVRGFRCQTPGCETLASAGGSLRAHVLRNRSVLLQWRLAPAEARRVRVFALNCSWRGTYTRFPCDRVLLGASCRDYLLPDVHDSVRYRLCLQQLPLRAEVAVVPPELAECVEFTAEPAAMQEIVVAMTAVGGSICVMLVVICLLVAYITENLMHPTFRRPSLRRQP
What are the official names of this protein?
Fibronectin type III domain-containing protein 10.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RPO1N_HALMO
Sequence: EFTSSTGDTVMIDEGALVEGTIDEDAVGAFGGEIVDTIVKQYGETRARVFINEVASLAMRAIMHFGFSIGIDDESISDAAEAQIDESMDNAYERVQELIDTYENDDLESLPGRTVDETLEMKIMQTLGKARDSAGDIADEHFDDDNPAVIMAESGARGSMLNLTQMAACVGQQAVRGERINRGYEGRTLSHFKPGDLSAEAHGFVEDSYRSGLTPREFFFHAMGGREGLVDTAVRTSKSGYLQRRLINALSELETQYDGTVRDTSDNIVQFEFGEDNTSPVKVSSSDDNEIDVDEIADRVLAAEFEDEGEEFAGEQATNLSESADDRMDRDRPSSHGAAPIDVPEVGDD
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms the clamp head domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1N, DNA-directed RNA polymerase subunit A'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_DEHM1
Sequence: MKKYKAGIINVTGYAGLELARILASHPSVELCSVTGRSLAGKKLSDAFPYLHSLDLPITESLEGEVDIAFMALPHKEGASLVPDLLSKGMRVIDISADFRLKDPPLYQAWYGFEHPCPELLAEAVYGLPELKRKDIASARLVANPGCYPTSAILGLAPAFKMDLIEPNAIVDAKSGLSGSGRTPTAKNIFCEASEDVCAYSIGTHRHQPEIVQELSLVGGGVIPRVTFCPHLVPMSRGILSSAYARLKQPVTDEEVKEIYRRFYKDEPFVKITAEPPHTRYTRGTNMCFIYPVVDALNERLIVISCIDNLVKGAAGQAVQNMNIMLGLSEDTGLKAIAALP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_EHRRW
Sequence: MINVYFSDNSCKQFLPGIKGSDIITHLFPELLNKAIAIKINDKSLDLSTEITEDCKFEVITLDSDEGLDIIRHDTAHIMAQAIKEMFPEVKTVVGPTIKDGFYYDFSTDHIFSSNELEKIEEKMREIIKKNESFIREVWTREEAIRFFSNKGEDYKVKIIAKIPIHENITVYKQGSFIDLCRGPHAPSTKISKAFKLTKVSGSYWEGNTNNAQLQRIYGTAWRTEEELKLYLNNLIEVEKRDHRKIGKELELFHIQNEALGQIFWHEKGLIIYRIIENYIRKKLENNGYIEVKTPYLLSKTLWEQSGHWDKFREHMFLSEIDNKVVAIKPMNCPCHVQIFNSKIRSYKDLPLRMAEFGTCHRYESSGALHGLMRVRSFTQDDAHIFCTEDQIIEEALKFCNLLMEVYEVFGFKDILVKFSDRPEKRAGSDKIWDKAEEALKASVKAANLNYVLNPGDGAFYGPKLEFTLKDAIGREWQCGTLQMDFVLPERLGAYYTGSDGKKHHPIMLHRAILGTIERFIGILIEHHSGKLPIWLAPVQLSILTITEDAIDYAISLKHKAMKQNIRAEVDITNEKINYKIRSHISKKIPVLWIIGKKEIETESVSIRYLESKDQHIMSSDKALKTLLSCASI
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATP_HAEIE
Sequence: MKYQKLENQEANWKWIYLIRKHREGENITRYEERSLQEAKAQELLESQNYPEKIEEWIKNHLSPALPIKLDQAIRARRKRFFNGEKQHTKKKSIDLEYAVWLRLSKYSRKMKMTLSETITYMIDERESKAQFENQMAAMKTSLKNLLK
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSL3_STAA8
Sequence: MKMRTIAKTSLALGLLTTGAITVTTQSVKAEKIQSTKVDKVPTLKAERLAMINITAGANSATTQAANTRQERTPKLEKAPNTNEEKTSASKIEKISQPKQEEQKTLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTNTPQPMQSTKSDTPQSPTIKQAQTDMTPKYEDLRAYYTKPSFEFEKQFGFMLKPWTTVRFMNVIPNRFIYKIALVGKDEKKYKDGPYDNIDVFIVLEDNKYQLKKYSVGGITKTNSKKVNHKVELSITKKDNQGMISRDVSEYMITKEEISLKELDFKLRKQLIEKHNLYGNMGSGTIVIKMKNGGKYTFELHKKLQEHRMADVIDGTNIDNIEVNIK
What is the function of this protein?
Secreted protein that plays an essential role in immune innate response inhibition by interacting with and inhibiting host TLR2.  In turn, bacteria recognition by immune cells is impaired and cytokine production is inhibited (PubMed:22665377, PubMed:22714643).  Mechanistically, by interacting with TLR2, blocks ligand binding and thus inhibits activation (PubMed:26283364).  Second, by interacting with an already formed TLR2-lipopeptide complex, prevents TLR heterodimerization and downstream signaling.  The interaction with host TLR2 does not involve sialyl Lewis X interactions (PubMed:26283364).
What are the official names of this protein?
Staphylococcal superantigen-like 3.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PAN3_YARLI
Sequence: MQVCVNFIQRRATELQPKVILINRLSAHLSTSPSPPLPHPLVTTSHTPVGALTPKPPNTSFGSHHQVSIAMPKFNINSPSFTPSVVDKAAIDSTGPAAPAAAPAFVPGKSPIDLEQIKNKLTISKDKKENAKSALPKLNPAVAGFTPGASASGSTTPKMATAPSFQPNQTSAINTNSNSSASATSQSGPPGASFQPNQSFQPGAASFQPRFQSGPSQIEPGYDNYYDEMSNGAVMAAAQNQQFPLQYHLYAPHYLSASRQRQLLSHQKTAKDFFLDPHLHQRLHKQSEDLLRVEGSSNLPRFVDKYHSLVLLDSNLNTKENGAPGESPQWVYKCMNGKDGKQYALRRIQGFVLTNEQAMTSVRKWQSIVHPAFVSLCEAFTTRDFGDASLCMIYDFLPSAETLFDLLNRGQQFSRDVIISYLLQLLSVLDTIHSAGLAAKTVDPTKILVCGPGRVRLNCCGLYDVINFDKDENVTLFQQQDLRNLGLLVLCLACNSVEATKNVEQSLTRLDSELQEIVQYLLSSNTSKTASRVLASLTPLLTATFNESLNTNDSLEHELRRELENGRLVRLMAKLNFITERPGPDPEMSQQWSETGDRYLIKLFRDYVFHQQDEMGKPVMDLGHVVRTLNKLDAGIDERITLISRNGQNCLIVSFKDLKQCIESALRDLE
What is the function of this protein?
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.  PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex subunit PAN3, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. PAN3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NODG_RHIML
Sequence: MFELTGRKALVTGASGAIGGAIARVLHAQGAIVGLHGTQMKNWRHWQLSLETGSSCSRLIWPIETKSRRLVRERKPILKASTSWSTNAGITKDGLFLHMADPDWDIVLEVNLTAMFRLTREITQQMIRRRNGRIINVTSVAGAIGNPGQTNYCASKAGMIGFSKSWRRRSTRNITVNCVAPGFIESAMTDKLNHKQKEKIMVAIPIHRMGTGTEVASAVAYLASDHAAYVTGQTIHVNGGMAMI
What is the function of this protein?
Proposed to modify Nod factor fatty acyl chain.
What are the official names of this protein?
Nodulation protein G, Host-specificity of nodulation protein C.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: 9DC1_SOLPI
Sequence: MGCVKLVFFMLYVFLFQLVSSSSLPHLCPEDQALALLQFKNMFTVNPNAFHYCPDITGREIQSYPRTLSWNKSTSCCSWDGVHCDETTGQVIALDLRCSQLQGKFHSNSSLFQLSNLKRLDLSNNNFIGSLISPKFGEFSDLTHLDLSDSSFTGVIPSEISHLSKLHVLLIGDQYGLSIVPHNFEPLLKNLTQLRELNLYEVNLSSTVPSNFSSHLTTLQLSGTGLRGLLPERVFHLSDLEFLDLSYNSQLMVRFPTTKWNSSASLMKLYVHSVNIADRIPESFSHLTSLHELDMGYTNLSGPIPKPLWNLTNIESLDLRYNHLEGPIPQLPIFEKLKKLSLFRNDNLDGGLEFLSFNTQLERLDLSSNSLTGPIPSNISGLQNLECLYLSSNHLNGSIPSWIFSLPSLVELDLSNNTFSGKIQEFKSKTLSAVTLKQNKLKGRIPNSLLNQKNLQLLLLSHNNISGHISSAICNLKTLILLDLGSNNLEGTIPQCVVERNEYLSHLDLSKNRLSGTINTTFSVGNILRVISLHGNKLTGKVPRSMINCKYLTLLDLGNNMLNDTFPNWLGYLFQLKILSLRSNKLHGPIKSSGNTNLFMGLQILDLSSNGFSGNLPERILGNLQTMKEIDESTGFPEYISDPYDIYYNYLTTISTKGQDYDSVRILDSNMIINLSKNRFEGHIPSIIGDLVGLRTLNLSHNVLEGHIPASFQNLSVLESLDLSSNKISGEIPQQLASLTFLEVLNLSHNHLVGCIPKGKQFDSFGNTSYQGNDGLRGFPLSKLCGGEDQVTTPAELDQEEEEEDSPMISWQGVLVGYGCGLVIGLSVIYIMWSTQYPAWFSRMDLKLEHIITTKMKKHKKRY
What is the function of this protein?
Involved in plant defense.  Confers resistance to the fungal pathogen C. fulvum through recognition of the AVR9 elicitor protein.
What are the official names of this protein?
Receptor-like protein 9DC1.
What is the protein family that this protein belongs to?
Belongs to the RLP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ATPH_CHLAT
Sequence: MSPLISAASVLAAGLAVGLASIGPGIGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFVS
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: KDPA_LISIN
Sequence: MKYIVMQDVFFIVLLLVLAVPLGIYMYKVMIGEKVFLSRVLEPVERFGYRLMGVNAAGMSAKRYAGSVLAFSAVGFIFVMAVLMLQGFLPLNPEGMKGLSFSLAFNTAASFVSNTNWQAYSGEAALSYFSQSIGLTVQNFVSAATGIAVLFAVIRGFIWKKQKTVGNFWQDLFRVTLYILLPLSLVLAILLVSQGVVQSFADYSVVESLENGAKQLIPLGPAASQIAIKQLGTNGGGFFGANSAFPFENPSSFTNLLEMLAILLIPVALVVMFGRAVKDSKQGRAIMTAMMIVFVVGVVAITISEQFAGPSYQGVTTSGSMEGKEVRFGVGGSSLFAASTTAASNGAVNAMHDSLTPLGGLVPMFFMQLGEVIFGGVGSGLYGMIGFIILTVFIAGLLVGRTPEYLGKKIEPYDMKMVCLLILVPPLLTLFGTAVAVMMPSVQASVSASGAHGFSEVLYAFTSMGNNNGSAFAGFAADTTFTNMVGAVMMLLARFIPLIAALYLAQNMAGKSPVAASSGTLSTKNGMFIGLLIGVVVLVGALSFLPALALGPIADFFTTFK
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLID_VIBCH
Sequence: MSLGPMGMNTGFDINGMVSKIVSAERVPKQQRIDNERTNIDTSISAYGRLRESLDTMKNLMTQFRQEKAFAVRKVDTSNEQVVSATATTEAIAGNYSVDVLQLAQSHKIASEVLDKDAKFGPGKLHISLGDKSFTLDVQGNSKLVDIVRGINGEKSNPGVRASIINDVEGPRLIVASNVSGKDHSVKMSAQAEPGNPLKQLEYKTLEQRVRDLEKARAQAQQLIAPLTPEQQKVAAKVAEKIGDAARLVDQEVAQEIRSAAQSAQGAAGEALNAGELTESAVKAAANAASEAKKYIRPEDRIPGWTETASGTLLDSYWEPEEELDAQGQKKAADVPGWSNTASGTLLDSYVTPQEAQQKLEQKLAQEKAQIEAAIRSGKMTPEEAKAQARAKLSPEERAYIEQVEKAQAALNAAQSAFDGYGGMTEVQSAQDSMVVLDGVATLSSNNNIIENAIEGVNLTLKGKTDRNQPPAEIGIEYDRERVRNDIEQFVAAYNQFFQTSKELAGVDPRTGQAGPLAGDSIVRSADSRLKTVFSSSIEQAPENLKSLTEFGITTTRQGTLEINYAMLDRQLNNNFTKLGEFFGGNQGFAKRVEDAISSMTGVTGSIRTREKSLNEQTYRLDDDQRSLDRRMESLEKRTHAKFSAMQDATSKMQSQLAGMMNALGG
What is the function of this protein?
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament.  Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
What are the official names of this protein?
Flagellar hook-associated protein 2, HAP2, Filament cap protein, Flagellar cap protein.
What is the protein family that this protein belongs to?
Belongs to the FliD family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: THIM_METM6
Sequence: MDFVAKNLTKLRETNPLVQNITNYVVMNSTANSLLALGASPVMAHAMDELEEMVSIASSLVINIGTLDEYWIPPMEKAAKIASDLKKPIILDPVGAGATKLRTNTALKILDFADISVLRGNFGEIAAVLGEHGKTKGVDSAAYDSNEAIELSKNAAKEFNTVSAVTGPIDYVSNGKEIYAISNGHPMLSKVTGTGCATTSIIGAFSAVDEPIKAAVSGLTVYGISAEMAFGEAPYPGTFQAKVYDWLYRIDEELVLEKAKVNKFEI
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: MNME_ECO55
Sequence: MSDNDTIVAQATPPGRGGVGILRISGFKAREVAETVLGKLPKPRYADYLPFKDADGSVLDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTIPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNDVIADLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPAEIWPEFIARLPAKLPITVVRNKADITGETLGMSEVNGHALIRLSARTGEGVEVLRNHLKQSMGFDTNMEGGFLARRRHLQALEQAAEHLQQGKAQLLGAWAGELLAEELRLAQQNLSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_HYDS0
Sequence: MRHRVKKKHFSRTAEQRVALMRSLARSLILFEKIESSEAKLKALRPFVERLITLAKKGDLASRRRALSLLPDKEAIRKLFTELAPRFEGRNGGYTRIVKLPNRKPGDSTELAIIEFVE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: SYFB_CHLPN
Sequence: MRIPITLLQTYFSEPLSTKEILEACDHIGIEAEIENTTLYSFASVITAKILHTIPHPNADKLRVATLTDGEKEHQVVCGAPNCEAGLIVALALPGAKLFDSEGQAYTIKKSKLRGVESQGMCCGADELGLDELQIQERALLELPEATPLGEDLATVLGNTSLEISLTPNLGHCASFLGLAREICHVTQANLVIPKEFSFENLPTTALDMGNDPDICPFFSYVVITGISAQPSPIKLQESLQALKQKPINAIVDITNYIMLSLGQPLHAYDASHVALDSLRVEKLSTPESLTLLNGETVLLPSGVPVVRDDHSLLGLGGVMGAKAPSFQETTTTTVIKAAYFLPEALRASQKLLPIPSESAYRFTRGIDPQNVVPALQAAIHYILEIFPEATISPIYSSGEICRELKEVALRPKTLQRILGKSFSIEILSQKLQSLGFSTTPQETSLLVKVPSYRHDINEEIDLVEEICRTESWNIETQNPVSCYTPIYKLKRETAGFLANAGLQEFFTPDLLDPETVALTRKEKEEISLQGSKHTTVLRSSLLPGLLKSAATNLNRQAPSVQAFEIGTVYAKHGEQCQETQTLAILLTEDGESRSWLPKPSLSFYSLKGWVERLLYHHHLSIDALTLESSALCEFHPYQQGVLRIHKQSFATLGQVHPELAKKAQIKHPVFFAELNLDLLCKMLKKTTKLYKPYAIYPSSFRDLTLTVPEDIPANLLRQKLLHEGSKWLESVTIISIYQDKSLETRNKNVSLRLVFQDYERTLSNQDIEEEYCRLVALLNELLTDTKGTINS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YMDA_SALTI
Sequence: MSVIKKNIPAIGLCICAFFIHSAVGQQTVQGGVIHFRGAIVEPLCDISTHAENIDLTCLREGKKQMHRIDLRQASGLPQDIQSIATVRLHYLDAQKSLAVMNIEYR
What are the official names of this protein?
Uncharacterized protein YmdA.
What is the protein family that this protein belongs to?
To the N-terminal of the FimA/PapA family of fimbria proteins.
Protein: REP_TYCS2
Sequence: MAQPKRFQINAKHYFLTFPKCSLSKEEALEQLLQLQTPTNKKYIKICRELHEDGQPHLHMLIQFEGKFNCKNNRFFDLVSPTRSAHFHPNIQGAKSSSDVKSYIDKDGDVLEWGTFQIDGRSARGGQQTANDAYAKAINAGRKSEALDVIKELAPRDYILHFHNINSNLNMVFQVPPAPYVSPFLSSSFDQVPDELEHWVSENVMDVAARPWRPVSIVIEGDSRTGKTMWARSLGPHNYLCGHLDLSQKVYSNNAWYNVIDDVDPHYLKHFKEFMGSQRDWQSNTKYGKPIQIKGGIPTIFLCNPGPQSSFKEYLDEEKNQTLKNWAIKNAIFVTIHQPLFTNTNQDPTPHRQEETSEA
What is the function of this protein?
Essential for the replication of viral ssDNA.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific region at the genome origin of replication.  It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities (By similarity).
What are the official names of this protein?
Replication-associated protein, Rep, Protein C1.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: VPN2_BPPHE
Sequence: MTEKKNTERQLTSVQEEVIKGFTTGYGITPESQTDAAALRREFLDDQITMLTWADGDLSFYRDITKRPATSTVAKYDVYLAHGRVGHTRFTREIGVAPISDPNLRQKTVNMKYVSDTKNMSIATGLVNNIEDPMRILTDDAISVVAKTIEWASFYGDSDLSENPDAGSGLEFDGLAKLIDKHNVLDAKGASLTEALLNQASVLVGKGYGTPTDAYMPIGVQADFVNQQLDRQVQVISDNGQNATMGFNVKGFNSARGFIRLHGSTVMELEQILDENRMQLPNAPQKATVKATLEAGTKGKFRDEDLTIDTEYKVVVVSDDAESAPSDVASVVIDDKKKQVKLEITINNMYQARPQYVAIYRKGLETGLFYQIARVPASKAVEGVITFIDVNDEIPETADVFVGELTPSVVHLFELLPMMRLPLAQVNASVTFAVLWYGALALRAPKKWARIKNVKYIATGNVFN
What are the official names of this protein?
Putative major capsid protein.
What are the subcellular locations of this protein?
Virion. Host membrane; Single-pass membrane protein.
Protein: A1AT4_MOUSE
Sequence: MTPSISWSLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFALRLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIVEAVKKLDQDTVFALANYILFKGKWKQPFDPENTEEAEFHVDESTTVKVPMMTLSGMLDVHHCSMLSSWVLLMDYAGNTTAVFLLPDDGKMQHLEQTLNKELISQFLLNRRRSDAQIHIPRLSISGNYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSKAVHKAVLTIDETGTEAAAATVLQVATYSMPPIVRFDHPFLFIIFEEHTQSPIFVGKVVDPTHK
What is the function of this protein?
Inhibitor of serine proteases.  Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase.
What are the official names of this protein?
Alpha-1-antitrypsin 1-4, Alpha-1 protease inhibitor 4, Serine protease inhibitor 1-4, Serine protease inhibitor A1d, Serpin A1d.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GTAB_STAAR
Sequence: MKKIKKAIIPAAGLGTRFLPATKAMPKEMLPILDKPTIQYIIEEAARAGIEDIIIVTGRHKRAIEDHFDSQKELEMVLKEKGKSELLEKVQYSTELANIFYVRQKEQKGLGHAISSARQFIGNEPFAVLLGDDIVESEVPAVKQLIDVYEETGHSVIGVQEVPEADTHRYGIIDPLTKNGRQYEVKKFVEKPAQGTAPSNLAIMGRYVLTPEIFDYLKTQKEGAGNEIQLTDAIERMNNDNQVYAYDFEGERYDVGEKLGFVKTTIEYALKDDSMREELTRFIKELGL
What is the function of this protein?
Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP.  This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i. e.  the predominant glycolipid found in the S. aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) (By similarity).
What are the official names of this protein?
UTP--glucose-1-phosphate uridylyltransferase, Alpha-D-glucosyl-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, Uridine diphosphoglucose pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 2 family.
Protein: HEMH_ACTPJ
Sequence: MNTNKIGVLLANLGTPDEPTTPAVKRYLKQFLSDPRVIDLPKFKWQFILNYMILSKRSPKVAKLYREIWTEQGSPLLAISRQQQQALQDYFNRQNQNVLVELGMSYGNPSIESATDRLIKAGVSKIIVLPLYPQYSSTTTASVLDAFARGLTQQRNIVPFEFIHSYHNDPLYIQALANTIQLAEDEKLLFSFHGIPKRYQTEGDFYPEHCQQTAQLVADKLSLTDEQWLVTYQSRFGDEEWLQPYTDETLETLPSQGVKKIAVICAGFSADCLETLEEIAEENKENFLNAGGQSYRYIPALNANTDHINALAKLIEAKI
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADB_PSYA2
Sequence: MVYQGNRITVTMLEDGIANMQYNAENESVNKFDTETNKQFAEVVNALEKADDVKGLIVTSSKGVFIAGADITEFVASFKQSEEEIKDWVININDAFNRFEDLPFPKVAAINGAALGGGCEMTLVCEYRVMSDKAIIGLPETQLGIFPGFGGTVRSTRVIGIDNALELIATGAPKKALDALKLGLVDATVAADDLQDAAIDLVKKCISGELDWKAKREEKLVAVKLNQLEQAMAFNSAKGMIFAKANPKQYPAPALAIAAIEKHVNLPRDKAIEVEAAGFAKAAKTPQAESLVGLFLSDQLVKKLAKQHSKKAHEINEAAVLGAGIMGGGIAYQAASKGLPIIMKDIKSEQLDLGMGEASKLLGKMVDRGKMTPAKMGETLSRIRPTLNYGDFAETDIVIEAVVENPNVKRAVLKEVEGLVKDDCILASNTSTISITFLAEALERPENFVGMHFFNPVHRMPLVEVIRGEKSSEEAIATTVALASKMGKVPVVVNDCPGFLVNRVLFPYFGAFDLLLKQGADFAHVDKVMEKFGWPMGPAYLIDVVGLDTGVHGAEVMAEGFPDRMKPDYKGAIELLYENKRLGQKNGVGFYKYEMDKRGKPKKVADEATYELLKTTTDSEKQTFDDQAIIDRTMLAFCNETVRCLEDNIVSTPSEADMAMIMGVGFPPFRGGPCRYIDQMGLDNYLALCEKYAHLGKAYEAPQKIRDMAAAGETFYATA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: PESC_PICST
Sequence: MAKIKKRGVSGNAKNFITRTQAVKKLQVSLSDFRRLCIFKGIYPREPRNKKKANKGSTAPVTFYYAKDIQYLSHEPVLAKFREHKTFAKKLQRALGRGEVSDAQKLEANRPKYTLEHIIKERYPTFLDALRDIDDPLNMLFLFANMPATDKVSHRVTKEAEKLTNQWLAYVAKERLIKKVFVSIKGVYYQANVKGQEIRWLVPFKFPTNIPTDVDFRIMLTFLEFYSTLLHFVLYRLYNDSNLIYPPTIDIEKLKGIGGLSSYVLQSKDQGVSALLPQDKKIVEDDVSVQGKELSTANISKALEADNEGEEHEEVEQETVENVELDKFEASATKTAVDSLVQPSKYASPTSTLFSKFIFYVGREVPLDILELCILSCGGSVVSEVALDDLKTNSPDAYKKLDLSNITHQIIDRPKILQKVAGRTYIQPQWIFDCINKSELLPVNKYAPGETLPPHLSPWGDAGSYNPEAEKVDQSENAEEEEEDEVDEDDEDADEDEEDEEEEDEEEDEDLKAQKELELEAAGVKFSEIAEKEKKAAKKASKKRPAEEDEEKELKKIMMTNKQRKLYKKMQYGIDKKETRTQELAKKKRKIEKTKAQLDKLSKK
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Pescadillo homolog, Nucleolar protein 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the pescadillo family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: PRSA_CLOBM
Sequence: MRSAKKLLSVLCLGVFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDENPRFKQVVSQMKMQYGEEFEKSEQGKEVIKEQKSQILDELITEKVLLQKGKELKVIPKDEELNKEADKKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLKDQIVIEKVINEATKGVKVEDKDAQKYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDGSKDKGGLLGDISYSDSNLDPTFLKAAIALKEGAISNPVHTQFGYHIIKINSKKEYPVKKFDAVKEDIKKQLKQEKQQEAYTKKIEEWKKASKIKIYEKNLL
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.