PharMolix/UniProtQA huggingface dataset:
Protein: GRPE2_BOVIN
Sequence: MAARLLWAVRRRMQPLAAHAASEGRGWLHPFSTATQRTAGEDCNSEDPPDELGPSLAERALKLKAVKLEKEVQDLTVRYQRAVADSENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEETEPADQKLTLEKIFRGLSLLEAKLKSVFAKHGLEKMTPIGDKYDPHEHELICHVPAGVGVQPGTVAFVRQDGYKLHGRTIRLAQVEVAVESQRRL
What is the function of this protein?
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.  Stimulates ATPase activity of mt-HSP70.  May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).
What are the official names of this protein?
GrpE protein homolog 2, mitochondrial, Mt-GrpE#2.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RS20_BRUAB
Sequence: MANTPSAKKAVRKIAARTEINKSRRSRVRTFVRKLEDALLSGDKQAAEVAFKAVEPELMRAASKGVVHKNTAARKVSRLAKRVKALNA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: PURA_BIFLS
Sequence: MPGIVLIGAQWGDEGKGKATDLIGTKVDYVARFNGGNNAGHSVVVGDESYALHLLPSGIINPNLTPVIGNGVVVDPEVLFEEIDGLESRGIDCSHLKVSEAAHIIAPYHRTLDKVTERFLGKHKIGTTGRGIGPAYADKINRVGIRVHDLFNADHLHDKVEASLHQKNQMLVKLYNRRPIDVDQTTEELLKLGERLKPYVANTGLILNKALDEGKTVLFEGAQATMLDVDHGTYPFVTSSNPTAGGACTGTGVGPTKITRVIGVSKAYVTRVGEGPFPTELLDESGEWLRQQGHEFGVTTGRPRRCGWFDAVVNRYASQVNGLTDIVLTKLDVLTGLKEIPICVAYDVDGERHDDMPTDQAAFAAAKPIYETMPGWDEDISDCHSFDELPATCQAYVKRLEELSGCRISVIGTGPQRDHVIQINSLVD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBBP9_RAT
Sequence: MASPTKAVIVPGNGGGDVATHGWYGWVRKGLEQIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHQVYALILVSAYTSDLGDENERASGYFSRPWQWEKIKANCPHIIQFGSTDDPFLPWKEQQEVADRLDAKLYKFTDRGHFQNTEFHELIRVVKSMLTPAL
What is the function of this protein?
Serine hydrolase whose substrates have not been identified yet (By similarity).  May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (By similarity).  May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699).
What are the official names of this protein?
Serine hydrolase RBBP9, B5T-overexpressed gene protein, Protein BOG, Retinoblastoma-binding protein 9, RBBP-9.
What is the protein family that this protein belongs to?
Belongs to the RBBP9 family.
Protein: RUVA_FLAPJ
Sequence: MIAHIQGKLVEKSPTEVVIDCNGVGYHVNISLHTYGLLPTTDFVKLFTHLIIKEDSHSLYGFAEKSEKEIFKLLISVSGIGANIARTMLSSIEPKQIINAIGSGDVGTIQSIKGIGVKTAQRTIIDLKEKVLKLYDLDQVSISQSNTNKDEALSALEVLGFIRKSAEKVVEKIVATMPDATVETIIKQALKNL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: APO1_ORYSI
Sequence: MMNPRRLPPLPSSTSSASAADDMDPRVWRRLPQPLVDRVLACLPTPSFLRLRAACRRFYHLLFSSPFLHSHLLLSPHLPFFAFVVPAAGHLLLLDPTATASWSRLPLPLPPVAGGPAAFSPAAASAGLLAFLSDASGHKTLLLANPITRLLAALPISPTPRLSPTVGLAAGPTSIIAVVAGDDLVSPFAVKNISADTFVADAASVPPSGFWAPSSLLPRLSSLDPGAGMAFASGRFYCMSSSPFAVLVFDVAENVWSKVQPPMRRFLRSPALVELGGGREGAARVALVSAVEKSRLSVPRSVRLWTLRGGGGGGGGGAWTEVARMPPEVHAQFAAAEGGRGFECAAHGDYVVLAPRGPVAQAPTSALVFDSRRDEWRWAPPCPYVVVAHHGGAGAAGFRVFAYEPRLATPAIGLLDATAPVALHGMHDG
What is the function of this protein?
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  Together with FL/APO2, involved in the temporal regulation of meristem identity during both vegetative and reproductive developments in an APO2-dependent manner (By similarity).  Promotes spikelet formation by suppressing the precocious conversion of inflorescence meristems to spikelet meristems, probably via a positive regulation of class-C floral homeotic genes, but not of class-B genes, and through the control of cell proliferation in meristems (PubMed:21119645).  Mediates culm development and strength/diameter enhancement at internodes (PubMed:21119645).  Required for the regulation of the plastochron, floral organ identity, and floral determinacy (By similarity).  Controls the number of primary rachis branches (PRBs) (PubMed:20151298).  May trigger the formation of vascular bundle systems which, consequently, promote carbohydrate translocation to panicles (PubMed:20151298).  Involved in ozone-induced grain yield regulation (PubMed:25923431).
What are the official names of this protein?
Protein ABERRANT PANICLE ORGANIZATION 1, F-box protein 321, OsFbox321, Protein STRONG CULM 2.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SLXA_GLOHA
Sequence: MGRFIFLSFGLLVVFLSLSGTGADCPSGWSSYEGHCYNIFHLFKTWAEAERFCRKQVKGAHLVSIESSEEADFVAQLVSENMKRYGIYIWIGLRVRGKKKQCSSQWSDGSSVSYQNWIEAESKTCLGLQKETEFRKWFNIYCGERNPFVCEA
What is the function of this protein?
Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factors IX (F9) and factor X (F10) in the presence of calcium with a 1 to 1 stoichiometry.
What are the official names of this protein?
Snaclec coagulation factor IX/factor X-binding protein subunit A, IX/X-bp subunit A, Halyxin subunit A.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: DUT_FRAT1
Sequence: MKVELKILNKELIKELPGYATEGSAAIDLRACISESIYLKSGECKLVATGIAINIANPNYAAMILPRSGLGHKKGLVLGNGTGLIDSDYQGELMVSCFNRSQETIEIEPLMRFAQLVIVPVVQANFEIVEDFSQQSVRATGGFGHTGV
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: MINC_WIGBR
Sequence: MIILDINQNYKYFMFNKVCLKFKIKNFNILVIYLYDIKEKNIYKTIKNKIKNFSYFFKKMPCIINIKYLSEEDQYFWKYFHKKLSNLGLCIIGVSGCNNKIWEKIITRNGLLIFKEQINKKIFYEKKNKITKINNNYIIDKPIRSGQTIYAKKKNLIIMNTVNSGAEVIADGDIHIYGIMRGRASAGASKDTKSQIFCTKLYAEFISIAGKNWINENVLNSYLGKPVRFYIKNDILTIQKFSL
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: RS6_RHILW
Sequence: MALYEHVFLARQDISAQQVDALVEQYKGVIEANGGKVGRIENWGLKSLTYRIKKNRKAHYALMDIDAPAAAVQEMERQMRISEDVLRYMTIAVEKHEEGPSAMMQKRDRDDRPREGGRGPREGGFGDRDRGPRPPREGGFGDREDRPRRPREDRV
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: MKAR_YARLI
Sequence: MVYVNAKNYFCDSIINNTDRVLSALIKYHGLSIIAVFLLAIGLFHVALKVVSYVAVLLDVFVLPPTNYLPYGSQRGAWAVVTGASDGIGKEYARQLGLRGFNVFLISRTESKLRELAQEIAEKSKVETKFLAIDVSTDSPQNYKDIETVLETIPSVSILINNVGLSHSIPTPFLETPPAELHNIIAINNLATLKITQLIAPKIVESVKEARATKKFQKGLILTMGSFGGLLPTPLLATYSGSKAFLQHWSNALAVELAPEHVDVELVVSYLVTSAMSKVRKTSALIPNPKQFVTATLSSVGRAGGAQEKFATSTPYWSHALLHWWIAQTVGVFSKLVAGFNYKMHVDIRKRALKKQARQAAGGVADPKNTTAAREGYATESLKNETLKH
What is the function of this protein?
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate.  Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation.  VLCFAs serve as precursors for ceramide and sphingolipids.
What are the official names of this protein?
Very-long-chain 3-oxoacyl-CoA reductase, 3-ketoacyl-CoA reductase, 3-ketoreductase, KAR, Microsomal beta-keto-reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: XER_SYNY3
Sequence: MFLPSPNNLSGLNQNILEELLRDKRSPNTRRTYAKALKDFFLTMAGEEPSPDVIAWFLSLDHFQAIAMVLRYRAELLAKDLKPATINVRLAAIKSLVNYARRVGKCQYTLEDVEGLKAETYRDTTGVSPTSFKQITDHITPDSLKGKRDLAIMRLLWDNALRRAEVCGLNVGDYQPTERQLLIKGKGKLGKQAITLSAKGMALINQWLTAIGPRPKNEPLFCTLDRATFGHRLSGNAIYNLVRTSAESAGIHKVMSPHRVRHSAITAALEATNGDTRKVQKLSRHSNLNTLMIYDDNRHQHQAQITDILADLL
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.
What are the official names of this protein?
Tyrosine recombinase slr0733.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPG_BUCAP
Sequence: MNIQKKEVYSFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAIDKLRFQSISNPELYENDSDFKIQISINKSQGTLIISDNGIGMTRQDVVENLGTIAKSGTKSFIKSLEKKEKNVKNELIGEFGVGFYSSFIVSKKVSVRTRFAGSKSNLGVLWESSGEGEYNITDIKKKTRGTEITLFLKKEEEEFLELWRIEGIVSKYSDHITVPVKIQKYDEKNKIYFWEKINKAKALWTQNKATISEKEYQEFYKHLTNDQNNPLFWSHNHVEGINEYISLLFIPEKAAWDIWNRDNKSGLKLYVKRVYIMDNSQAFLPNYLRFIRGLIDSNNLPLNVSREILQDNSITQNLKKALIKRSLKMLQTLSKKDNEKYQIFWNQFGSVLKEGPAEDSNNLNLIASLLRFTSIQNNSSEQNISLEKYISNMHEKQEKIYYITADSYTSAKNSPHLELFNKKNIDVLLLSDRIDEWMMNYLTEFEGKKFQSISKEDLSLNKLTKENENKKETSTEMIEFLKKVKKTLGDKVKSVRLTYRLTETPCIVLSDSNEMSTQMAKLFSAAGQSVPELKYIFEINPEHKLIQKICKIKENEKFDEWIKLLLDQALFAEKGNLENPHEFIARTNKLILEQ
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STP1_MOUSE
Sequence: MSTSRKLKTHGMRRGKNRAPHKGVKRGGSKRKYRKSVLKSRKRGDDASRNYRSHL
What is the function of this protein?
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:10781074, PubMed:15163613, PubMed:15189834, PubMed:15083521, PubMed:28366643).  In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643).  The histone H2AB1-H2BC1/TH2B dimer is required for loading of TNP1 onto chromatin (PubMed:28366643).
What are the official names of this protein?
Spermatid nuclear transition protein 1, STP-1, TP-1.
What is the protein family that this protein belongs to?
Belongs to the nuclear transition protein 1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Loaded onto the nucleosomes of condensing spermatids (PubMed:28366643). Inclusion of the H2AB1- H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition protein TNP1 (PubMed:28366643).
Protein: ARGC_METMJ
Sequence: MEIAIIGASGYTGGELMRLLLHHPSADVVAATSRKLDGTPVASVHPHLRGLTDLVFRNAGAGDIDADFAFLAVPHTAAMKVAGTLAERGIRTVDLSADYRLPKDVYEKIYGVTHEAYFEAPYGLPELHRDEIRGASFVANPGCFPTGATLAAAPLAKFAHTIIYDSKTGVSGAGTSPSATTHYPNVGDNFSAYKWTSHRHLAEMKQEAARLGSTARCYFTPHLLPVNRGILTTAHILLREPMGQDEVEALYKKFYADEFFVRYQKPTLAAVRGTNFCDVAVESEGDRVVAVSAIDNLVKGASGQAIQNMNLMCGFAEDTGLRTAGMFP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBIN_SALEP
Sequence: MKKTLMLLAMVVALVILPFFINHGGEYGGSDGEAESQIQAIAPQYKPWFQPLYEPASGEIESLLFTLQGSLGAAVIFYILGYCKGKQRRDDRA
What is the function of this protein?
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
What are the official names of this protein?
Cobalt transport protein CbiN, Energy-coupling factor transporter probable substrate-capture protein CbiN, ECF transporter S component CbiN.
What is the protein family that this protein belongs to?
Belongs to the CbiN family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CBPA_ECO5E
Sequence: MELKDYYAIMGVKPTDDLKTIKTAYRRLARKYHPDVSKEPDAEARFKEVAEAWEVLSDEQRRAEYDQMWQHRNDPQFSRQFQHGDGQSFNAEDFDDIFSSIFGQHARQSRQRPAARGHDIEIEVAVFLEETLTEHKRTISYNLPVYNAFGMIEQEIPKTLNVKIPAGVGNGQRIRLKGQGTPGENGGPNGDLWLVIHIAPHPLFDIVGQDLEIVVPVSPWEAALGAKVTVPTLKESILLTIPPGSQAGQRLRVKGKGLVSKKQTGDLYAVLKIVMPPKPDENTAALWQQLADAQSSFDPRKDWGKA
What is the function of this protein?
DNA-binding protein that preferentially recognizes a curved DNA sequence.  It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock.  Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK.  Its activity is inhibited by the binding of CbpM.
What are the official names of this protein?
Curved DNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SECE_STRVG
Sequence: MTDALGSIDMPDAEDETREKKARKGGKRGKKGPLGRLALFYRQIVAELRKVVWPTRNQLTTYTTVVIVFVVIMIGLVTVIDFGFEKAIKFVFG
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: OCLN_MOUSE
Sequence: MSVRPFESPPPYRPDEFKPNHYAPSNDMYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTGLFGGSLNYPYSGFGYGGGYGGGYGGYGYGYGGYTDPRAAKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAILGIMVFIATIVYIMGVNPTAQASGSMYGSQIYMICNQFYTPGGTGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKNVSAGTQDMPPPPSDYAERVDSPMAYSSNGKVNGKRSYPESFYKSTPLVPEVAQEIPLTLSVDDFRQPRYSSNGNLETPSKRAPTKGKAGKGKRTDPDHYETDYTTGGESCEELEEDWVREYPPITSDQQRQLYKRNFDAGLQEYKSLQAELDDVNKELSRLDKELDDYREESEEYMAAADEYNRLKQVKGSADYKSKRNYCKQLKSKLSHIKRMVGDYDRRKP
What is the function of this protein?
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
What are the official names of this protein?
Occludin.
What is the protein family that this protein belongs to?
Belongs to the ELL/occludin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, tight junction.
Protein: PNP_METPP
Sequence: MSLFNKITKTFQWGQHTVTLETGEIARQSGGAVIVDMDGTVVLATVVAAKNPKPGQDFFPLTVDYIEKTYAAGKIPGSFFKREGRPSELETLTSRLIDRPLRPLFPEGFYNEVQVVVHVLSLNPEASADIAALIGSSAALAISGIPFNGPIGAARVGYINGEYVLNPGPTQLADSKLDLIVAGTEAAVLMVESEADQLPEDIMLGGVVFGHEQGNIAVRVINELVREAGKPEWQWTPPAKDEDFIAKVNGLGEAKLRAAYQIRSKQDRTQATRAAYAEVLAALAAEGAAVDKVKVENLLFDIEAKIVRSQILAGEPRIDGRDTRTVRPIEIRSSVLPRTHGSALFTRGETQALVITTLGTERDTQRIDALAGEFEDRFMFHYNMPPFATGETGRVGSPKRREIGHGRLAKRALIPVLPKKDEFAYAIRVVSEITESNGSSSMASVCGGCLSMMDAGVPLKAHVAGIAMGLIKDGNRFAVLTDILGDEDHLGDMDFKVAGTTTGVTALQMDIKIQGITKEIMQVALAQAKEARLHILGKMVEALGGAKEELSVFAPRLYVMKINPEKIRDVIGKGGATIRALTEETGTQINIEEDGTITIASTDGDKAQAAMKRIEEITAEAEIGKVYEGPVTKILDFGALVNILPGKDGLLHISQIAHQRVEKVTDFLTEGQIVKVKVLETDEKGRIKLSLKALLERPEGYVEEERPRREYGDRGDRGDRGRDRGDRPPRRERGDAPQAAPESDVPSPQAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_TALAL
Sequence: MTNIRKTHPLMKIVNSSFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFMHVGRGLYYGSYLFMETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTELVEWIWGGFSVDKATLTRFFAFHFIMPFIIAALAGVHLLFLHETGSNNPSGLSSDTDKIPFHPYYTIKDILGMLVLILMLSLLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILALIPFLHTSKQRSMMFRPMSQCLFWLLVADLLTLTWIGGQPVEHPFITIGQLASILYFLLILVLMPLTSLMENSMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: E1A_ADE02
Sequence: MRHIICHGGVITEEMAASLLDQLIEEVLADNLPPPSHFEPPTLHELYDLDVTAPEDPNEEAVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQPEQRALGPVSMPNLVPEVIDLTCHEAGFPPSDDEDEEGEEFVLDYVEHPGHGCRSCHYHRRNTGDPDIMCSLCYMRTCGMFVYSPVSEPEPEPEPEPEPARPTRRPKLVPAILRRPTSPVSRECNSSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQAVECIEDLLNESGQPLDLSCKRPRP
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E1A protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome.  Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore.  This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K.  Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection.  Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation.  The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif.  Interacts with host TBP protein; this interaction probably disrupts the TBP-TATA complex.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).  Promotes the sumoylation of host ZBED1/hDREF with SUMO1 (By similarity).
What are the official names of this protein?
Early E1A protein, Early E1A 32 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1A protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RNH2_SALAR
Sequence: MIEFVYPHTHLVAGVDEVGRGPLVGAVVTAAVILDPARPIVGLNDSKKLSEKRRLALYDEIKEKALSWSLGRAEPHEIDELNILHATMLAMQRAVAGLHIAPEYVLIDGNRCPALPVPSMAVVKGDSRVAEISAASILAKVTRDAEMAALDIIFPQYGFAQHKGYPTAFHLEKLAQYGATAHHRRSFAPVKRALELAS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSE_SHIFL
Sequence: MIRFEHVSKAYLGGRQALQGVTFHMQPGEMAFLTGHSGAGKSTLLKLICGIERPSAGKIWFSGHDITRLKNREVPFLRRQIGMIFQDHHLLMDRTVYDNVAIPLIIAGASGDDIRRRVSAALDKVGLLDKAKNFPIQLSGGEQQRVGIARAVVNKPAVLLADEPTGNLDDALSEGILRLFEEFNRVGVTVLMATHDINLISRRSYRMLTLSDGHLHGGVGHE
What is the function of this protein?
Part of the ABC transporter FtsEX involved in cellular division.  Important for assembly or stability of the septal ring.
What are the official names of this protein?
Cell division ATP-binding protein FtsE.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the membrane through an interaction with FtsX.
Protein: ATPG_YERPA
Sequence: MAGAKEIRSKIASVQNTQKITKAMEMVAASKMRKSQERMAASRPYAETMRSVIGHLALGNLEYKHPYLEERDVKRVGYLVVSTDRGLCGGLNINLFKRLLAEMKGWSEKGVECDLALIGSKAASFFGSVGGKIVAQVTGMGDNPSLSELIGPVKVMLQAYDEGRLDKLYIVNNKFINTMSQEPRIMQLLPLPPAEDGELKKKSWDYLYEPDPKALLDTLLRRYVESQVYQGVVENLASEQAARMVAMKAATDNGGSLIKELQLVYNKARQASITQELTEIVGGASAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.