PharMolix/UniProtQA huggingface dataset:
Protein: ARI4B_HUMAN
Sequence: MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR
What is the function of this protein?
Acts as a transcriptional repressor (PubMed:12724404).  May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404).  Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A.  Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation.  Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier.  Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis.  May function as a leukemia suppressor (By similarity).
What are the official names of this protein?
AT-rich interactive domain-containing protein 4B, ARID domain-containing protein 4B, 180 kDa Sin3-associated polypeptide, Sin3-associated polypeptide p180, Breast cancer-associated antigen BRCAA1, Histone deacetylase complex subunit SAP180, Retinoblastoma-binding protein 1-like 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Cytoplasmic in breast cancer cells.
Protein: DCAM3_ARATH
Sequence: MAVSATGFEGFEKRLEISFFETTDFLDPQGKSLRSLTKSQLDEILTPAECTIVSSLTNSFVDSYVLSESSLFVYPYKIIIKTCGTTKLLLSIPHILRLADSLCLTVKSVRYTRGSFIFPGAQSYPHRSFSEEVALLDDYFGKLNAGSKAFVMGGSDNNPQRWHVYSASSTEESAVCDKPVYTLEMCMTGLDNIKASVFFKTNSVSASEMTISSGIRNILPGSEICDFNFEPCGYSMNSIEGDAVSTIHVTPEDGFSYASFETVGYDLKALNFKELVDRVLVCFGPEEFSVAVHANLGTEVLASDCVADVNGYFSQERELEELGLGGSVLYQRFVKTVECCSPKSTLGFC
What is the function of this protein?
Essential for biosynthesis of the polyamines spermidine and spermine.  Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme 3, AdoMetDC3.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic AdoMetDC family.
Protein: GCS2_BURCJ
Sequence: MALETFVNSEPFTFGVELEIQVVNTHNYDLTKAASDLMRLIQGETFPGNITPEITESMIELSTGICHSHEQAVSELHAIRDVLVKAADQLNVGLAGGGTHAFQQWSDRQIYDAPRFQYISELYGYLAKQFTVFGQHVHIGCPDPDSALFLLHSMSRFIPHFIALSASSPFVQNVDTGFHSARLNSVFAFPLSGRAPFVLTWDSFEEYFTKMVNTGVVNSMKDFYWDIRPKPGYGTIEVRVMDTPLSVDRAAAIACYIQTLARYLLTDRPLKLSEDDYLVYTFNRFEACRFGLEGTCVNPQTGERRTIAEDILDTLDRIAPHAAALGSRAALDEIGALAKARVNDASWLRTVFKQEKSLNETVRQQCLRWRE
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: TRPA_EDWI9
Sequence: MTRYQTLFTHLQRRQEGALVPFVTLGDPTPSLSLQIIDALVESGADALELGIPFSDPLADGPVIQSATLRALQAGVTPERCFTLLATLREKYPQLPIGLLMYANLVVNPGIDTFYRRCAQAGIDSVLIADVPLEESAPFHAAAQRYGVAPIYLCPPNADDVLLQQLAARSQGYVYLLSRAGVTGSDRPCLPPLRHLTTRLAALGAAPTLQGFGIQTPDQVRSALDGGAAGAISGSAVVDLIARHLDTPPQMLQQLRAFIQTMKAATRA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: BSHC_STAES
Sequence: MKCNTLKLTEQDQFINKIKNSESQITSFYEYDAAKKESFYRRLKTPNNGREFHLSRVIKSYMNELKLTHQQLNNIDALADGAKVVIGGQQAGLFGGPLYTFHKIFSIITLSRQLSEEYDTPIVPVFWIAGEDHDFEEVNHTYAFNNKETTLKKVKYHTMTPPDSNVSRYTPDKNELKASLNHFFKEMKETVHTQDVYQMCVNIINQFDSWTDIFKGLIHEVFKDYGILFIDAQYPELRQMEKPLFKEILEKRNQIDQSFRETQIRKTQQQLPSMIQTETNTHLFIHEDGMRQLLNFDGTYFKLNKTEKRYTKQNLLDIIEREPERISNNVVTRPVVEEWLFNTVAFIGGPSEIKYWAELKDVFDTLNVEMPIVMPRLRITYLYARTKKLLKQYNLSIESVIANGVEQERQHFVREKASNNFINEVEEMKIQQQELYNNLFTYVENNHDNQLLLEKNNQIHLNQYDYLIKRYLLNIERENDISMRQFREISETLHPMGGLQERVWNPLQIMNDFGIDVFSPTTYPPLSYSFDHLIINP
What is the function of this protein?
Involved in bacillithiol (BSH) biosynthesis.  May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.
What are the official names of this protein?
Putative cysteine ligase BshC.
What is the protein family that this protein belongs to?
Belongs to the BshC family.
Protein: CSPLE_PHYPA
Sequence: MATAWESEYFDKVTPGERERAVPPMVPQQTPPPVYIQPQVSRNGIVASIVLRLLTLIFAVVALAVLASNTGSFQVSTGSATSVKTIKFTILSAFTYLFAVCGVVAVYSLLLIIVEMIDLAVRGFTTHTLVAIFVFVLDQTMAYVLISAASASANGVKVSRDESNITGYKFDISCSNLGIDDYCTKASASVAIAFIAFLFMAITAGVSARRLFKLP
What are the official names of this protein?
CASP-like protein UU3, PpCASPLUU3.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIMO_ECOLC
Sequence: MSKVTPQPKIGFVSLGCPKNLVDSERILTELRTEGYDVVPSYDDADMVIVNTCGFIDSAVQESLEAIGEALNENGKVIVTGCLGAKEDQIREVHPKVLEITGPHSYEQVLEHVHHYVPKPKHNPFLSLVPEQGVKLTPRHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPIGEVLSEAKRLVDAGVKEILVISQDTSAYGVDVKHRTGFHNGEPVKTSMVSLCEQLSKLGIWTRLHYVYPYPHVDDVIPLMAEGKILPYLDIPLQHASPRILKLMKRPGSVDRQLARIKQWREICPELTLRSTFIVGFPGETEEDFQMLLDFLKEARLDRVGCFKYSPVEGADANALPDQVPEEVKEERWNRFMQLQQQISAERLQEKVGREILVIIDEVDEEGAIGRSMADAPEIDGAVYLNGETNVKPGDILRVKVEHADEYDLWGSRV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_PSEA6
Sequence: MSAKPTKINLLNFNRAGLREYFSSIGEKPFRADQMMKWIYQAGVSDFDQMTNLNKALREKLKAQCEVKAPEIAYQQGASDGTIKFALRLEGGQEVETVWIPDEDRATLCVSSQVGCALECTFCSTAQQGFNRNLSVSEIIGQVWRVATTIGLSNDSAKRPITNVVMMGMGEPLLNLKNVVPAMDLMLDDLAFGLSKRRVTLSTSGVVPALDMLGDQIDVALAISLHAPDDKLRDEIVPINKKYPIQEFLAGVRRYLAKSNANQGKVTVEYVMLNGINDSTDQAHELAKVLADTPCKINLIPFNPYPGSPYSRSSNSRIDRFAKVLSSYGLMVVVRKTRGDDIDAACGQLVGDVVDRTKRMLKKQMKGDEISVKMEH
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HGD_PSEPF
Sequence: MNLDSALAYQSGFGNEFSSEALPGALPVGQNSPQKAPYGLYTELFSGTAFTMTRSEARRTWMYRIQPSANHPAFVKLERQLAGGPLGEVTPNRLRWNPLDLPTEPTDFIDGLVSMAANSGADKPAGISIYHYGANRSMERVFFNADGELLLVPQLGRLRIATELGVLDVAPLEIAVLPRGLKFRVELLDPQARGYVAENHGAPLRLPDLGPIGSNGLANPRDFLTPVAAYENLQQPTTLVQKFLGQLWGTELNHSPLNVVAWHGNNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTSVHGLANLDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLIQGEYDAKAEGFVPGGASLHSCMSAHGPDGETCTKAINADLKPAKIDNTMAFMFETSQVLRPSRFALDCPQLQSTYDACWATLPATFDPTRR
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: TREF_ECOL5
Sequence: MLNQKIQNPNPDELMIEVDLCYELDPYELKLDEMIEAEPEPEMIEGLPASDALTPADRYLELFEHVQSAKIFPDSKTFPDCAPKMDPLDILIRYRKVRRHRDFDLRKFVENHFWLPEVYSSEYVSDPQNSLKEHIDQLWPVLTREPQDHIPWSSLLALPQSYIVPGGRFSETYYWDSYFTMLGLAESGREDLLKCMADNFAWMIENYGHIPNGNRTYYLSRSQPPVFALMVELFEEDGVRGARRYLDHLKMEYAFWMDGAESLIPNQAYRHVVRMPDGSLLNRYWDDRDTPRDESWLEDVETAKHSGRPPNEVYRDLRAGAASGWDYSSRWLRDTGRLASIRTTQFIPIDLNAFLFKLESAIANISALKGEKETEALFRQKASARRDAVNRYLWDDENGIYRDYDWRREQLALFSAAAIVPLYVGMANHEQADRLANAVRSRLLTPGGILASEYETGEQWDKPNGWAPLQWMAIQGFKMYGDDLLGDEIARNWLKTVNQFYLEQHKLIEKYHIADGVPREGGGGEYPLQDGFGWTNGVVRRLIGLYGEP
What is the function of this protein?
Hydrolyzes trehalose to glucose.  Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
What are the official names of this protein?
Cytoplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C_VSIVS
Sequence: MRLKHNEMRSPIMSCSKRMEWKSMPSPLIFKQQMILTQSLNQKLKTIKACMYQIRKLSKLKALYRGL
What is the function of this protein?
May play a role in viral pathogenesis or transmission by insects vectors.
What are the official names of this protein?
Protein C'.
What is the protein family that this protein belongs to?
Belongs to the rhabdoviruses C protein family.
Protein: FABZ_HALHL
Sequence: MSERDAQGATDIEGIMNLLPHRYPLLLIDRVLDFQPHEHLASIKNVTINEPFFVGHFPQKPVMPGVLILESLAQACGMLAFKSVQDTLTDNDVLYLVGIDKARFKRPVQPGDQLRHDVSVRRVTRGIWIFEARGSVDGELAAECEIRCTVRTV
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPRX_ORYLA
Sequence: MMADKTSPMITSDHSISNFSTGLFGPHPTVPPDVGVVTSSQSQMKDLFGLFCMVTLNLIALLANTGVMVAIARAPHLKKFAFVCHLCAVDVLCAILLMPLGIISSSPFFGTVVFTILECQVYIFLNVFLIWLSILTITAISVERYFYIVHPMRYEVKMTINLVIGVMLLIWFKSLLLALVTLFGWPPYGHQSSIAASHCSLHASHSRLRGVFAVLFCVICFLAPVVVIFSVYSAVYKVARSAALQQVPAVPTWADASPAKDRSDSINSQTTIITTRTLPQRLSPERAFSGGKAALTLAFIVGQFLVCWLPFFIFHLQMSLTGSMKSPGDLEEAVNWLAYSSFAVNPSFYGLLNRQIRDELVKFRRCCVTQPVEIGPSSLEGSFQENFLQFIQRTSSSSETHPSFANSNPRNMENQAHKIPGQIPEEQA
What are the official names of this protein?
Probable G-protein coupled receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DAPA_THESQ
Sequence: MFRGVGTAIVTPFKNGELDLESYERLVRYQLENGVNALIVLGTTGESPTVNEDEREKLVSRTLEIVDGKIPVIVGAGTNSTEKTLKLVKQAEKLGANGVLVVTPYYNKPTQEGLYQHYKYISERTDLGIVVYNVPGRTGVNVLPETAARIAADLKNVVGIKEANPDIDQIDRMVSLTKQARSDFMVWSGNDDRTFYLLCAGGDGVISVVSNVAPKQMVELCAEYFSGNLEKSREVHRKLRPLMKALFVETNPIPVKAALNLMGFIENELRLPLVPASEKTVELLRNVLKESGLL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CATH_MOUSE
Sequence: MWAALPLLCAGAWLLSTGATAELTVNAIEKFHFKSWMKQHQKTYSSVEYNHRLQMFANNWRKIQAHNQRNHTFKMALNQFSDMSFAEIKHKFLWSEPQNCSATKSNYLRGTGPYPSSMDWRKKGNVVSPVKNQGACGSCWTFSTTGALESAVAIASGKMLSLAEQQLVDCAQAFNNHGCKGGLPSQAFEYILYNKGIMEEDSYPYIGKDSSCRFNPQKAVAFVKNVVNITLNDEAAMVEAVALYNPVSFAFEVTEDFLMYKSGVYSSKSCHKTPDKVNHAVLAVGYGEQNGLLYWIVKNSWGSQWGENGYFLIERGKNMCGLAACASYPIPQV
What is the function of this protein?
Important for the overall degradation of proteins in lysosomes.
What are the official names of this protein?
Pro-cathepsin H, Cathepsin B3, Cathepsin BA.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: CALD1_CHICK
Sequence: MDDFERRRELRRQKREEMRLEAERLSYQRNDDDEEEAARERRRRARQERLRQKEEGDVSGEVTEKSEVNAQNSVAEEETKRSTDDEAALLERLARREERRQKRLQEALERQKEFDPTITDGSLSVPSRREVNNVEENEITGKEEKVETRQGRCEIEETETVTKSYQRNNWRQDGEEEGKKEEKDSEEEKPKEVPTEENQVDVAVEKSTDKEEVVETKTLAVNAENDTNAMLEGEQSITDAADKEKEEAEKEREKLEAEEKERLKAEEEKKAAEEKQKAEEEKKAAEERERAKAEEEKRAAEERERAKAEEERKAAEERERAKAEEERKAAEERAKAEEERKAAEERAKAEEERKAAEERAKAEKERKAAEERERAKAEEEKRAAEEKARLEAEKLKEKKKMEEKKAQEEKAQANLLRKQEEDKEAKVEAKKESLPEKLQPTSKKDQVKDNKDKEKAPKEEMKSVWDRKRGVPEQKAQNGERELTTPKLKSTENAFGRSNLKGAANAEAGSEKLKEKQQEAAVELDELKKRREERRKILEEEEQKKKQEEAERKIREEEEKKRMKEEIERRRAEAAEKRQKVPEDGVSEEKKPFKCFSPKGSSLKIEERAEFLNKSAQKSGMKPAHTTAVVSKIDSRLEQYTSAVVGNKAAKPAKPAASDLPVPAEGVRNIKSMWEKGNVFSSPGGTGTPNKETAGLKVGVSSRINEWLTKTPEGNKSPAPKPSDLRPGDVSGKRNLWEKQSVEKPAASSSKVTATGKKSETNGLRQFEKEP
What is the function of this protein?
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments).  Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure.  In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin.  This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin.  Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin.  Also plays an essential role during cellular mitosis and receptor capping.
What are the official names of this protein?
Caldesmon, CDM.
What is the protein family that this protein belongs to?
Belongs to the caldesmon family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, myofibril. Cytoplasm, cytoskeleton, stress fiber. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).
Protein: ZITB_YERPS
Sequence: MAVSAIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADTGHMLTDSAALFIALMAVHFSQRKPDPRHTFGYLRLTTLAAFVNAAALLLIVILIVWEAVHRFFSPHEVMGTPMLIIAIAGLLANIFCFWILHKGEEEKNINVRAAALHVLSDLLGSVGAMIAAIVILTTGWTPIDPILSVLVSVLILRNAWRLLKESFHELLEGAPQEIDINKLRKDLCTNIYEVRNIHHVHLWQVGEQRLMTLHAQVIPPLDHDALLQRIQDYLLHHYRISHATVQMEYQHCGTPDCGINQAAPADGHHRHHHHE
What is the function of this protein?
Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc.  It may contribute to zinc homeostasis at low concentrations of zinc.
What are the official names of this protein?
Zinc transporter ZitB.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DATPH_BPPMB
Sequence: MMTMTPRDLMRAQYVTRWQIVPTTRSQSVAQHSWAVAMLAMNLWCRRTGGQPGEAATDVELGKIAVMALWHDAPEVFTGDINTPTKIFLNASNALDELENTAGDGYLESMDGGPIRTCVKIADFLEAMYWLMEHGDGHYANNQLHGLNERFHQYLNEHAPLWRDSAVALWKELSDVNAETTTFQRVNYLKANDA
What is the function of this protein?
Catalyzes the hydrolysis of dATP, dADP and dAMP into dA (PubMed:33926954).  This step is essential for Z-genome synthesis (containing aminoadenine instead of adenine).  Specifically removes dATP and its precursor dADP from the nucleotide pool of the host, preventing the incorporation of A into the phage genome and favoring the integration of the Z-base into the viral genome (PubMed:33926954).
What are the official names of this protein?
dATP triphosphohydrolase, dATPase.
What is the protein family that this protein belongs to?
Belongs to the Caudovirales dATP triphosphohydrolase family.
Protein: KCJ10_HUMAN
Sequence: MTSVAKVYYSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV
What is the function of this protein?
May be responsible for potassium buffering action of glial cells in the brain.  Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.  Can be blocked by extracellular barium and cesium (By similarity).  In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
What are the official names of this protein?
ATP-sensitive inward rectifier potassium channel 10, ATP-dependent inwardly rectifying potassium channel Kir4.1, Inward rectifier K(+) channel Kir1.2, Potassium channel, inwardly rectifying subfamily J member 10.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
Protein: A13_FOWPN
Sequence: MGIIDTFVITAVTVIIFCLLIYAAYKRYKCIPSPDDRDKVLKSTLNDDTLFNQTLTPDQVKALHRLVTSSI
What is the function of this protein?
Essential for the encapsidation of DNA into immature virions (IV) and the subsequent maturation of IV into mature virions (MV).
What are the official names of this protein?
Virion membrane protein A13 homolog.
What is the protein family that this protein belongs to?
Belongs to the chordopoxvirinae A13 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Note=The mature virion is located in the cytoplasm of infected cells and is probably released by cell lysis.
Protein: PAFA_MYCA1
Sequence: MQRRIMGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATAECDNLVQLVTHDRAGEWVLEDLLVDAEQRLADEGIGGDIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKAATFCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMCETTTMLKVGTAALVLEMIEAGVPFRDFSLDNPIRAIREVSHDITGRRPVRLAGGRQASALDIQREYYSRAVEHLQTREPNAQIEQIVDLWGRQLDAVESQDFAKVDTEIDWVIKRKLFQRYQDRYNMELSDPKIAQLDLAYHDIKRGRGVFDLLQRKGLAARVTTDEDIAEAVDTPPQTTRARLRGEFISAAQAAGRDFTVDWVHLKLNDQAQRTVLCKDPFRAVDERVKRLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: CALGL_PSETE
Sequence: MAATLTPEQITEYKGIFEMFDEEGNGLVKTDDLESLMSLIGINPTKRDLANMAKDVDKDKKGTFNCDGFLVLMGIYHEKSKNQDEELRAAFKVFDKEHKGYIEWDTLKYVLMNAGEPLNEHEAELMMKEADKDGDGTIDYEEFVAMMTGESFKLTQ
What is the function of this protein?
May be involved in the cellular control mechanism of the secretion of toxins from the gland into the venom.
What are the official names of this protein?
Calglandulin.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family. Calglandulin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Not found in venom.
Protein: DRS1_ASPTN
Sequence: MAPKQKDDDFVLTLSDDENDAFNNFDVDGDDGDDGDELASSGTKKRKRDTAETTQNTSKKQKQQKPVKNGLKKNKKGQAETPAEEEQEEPQEEEDAGEDDGALDSDFEFDVGGVANTVVEGFDGWGMGNAEDEGAAKKGDKKAVDIDDIISRRQAKKEAAEAKKKKKQSEAQDNESWDGVAEDEDAESDGGMSVDFQDDELLAADGFGMGADGEDESDNEEAQDESGSDNDSDDDEEKDSEDDDDEAASDNDSVATPVGHPEDEASDNDSDAESEIDAEEQEKRKAFFAPEEEKTKEQADGAQRSFQEFNLSRPILRGLAAVNFTNPTPIQRKTIPVALLGKDIVGSAVTGSGKTAAFVVPILERLLFRPRKVPTSRVAILMPTRELAVQCYNVATKLATYTDITFCQLVGGFSLREQENILKKRPDVIIATPGRFIDHMRNSASFTVDTLEILVLDEADRMLEDGFADELNEILTTIPKSRQTMLFSATMTDTVDKLIRVGLNRPVRLMVDSKKNTSLTLVQEFVRLRPGREDKRLGYLLYLCKEIYTGRVIVFFRQKREAHRVRIVFGLLGLKAAELHGSMSQEQRIKSVENFRDGKVAFLLATDLASRGLDIKGVETVINYEAPQSHEIYLHRVGRTARAGRSGRACTIAAEPDRKVVKAAVKASKAQGAKVASRVVDPAVADQWAKKAADLEEEINEVLEEEKTEKQLAQAEMQVTKGENLIKHEAEIMSRPKRTWFESEKDKRAARKLGAAQLNGPDAGLSKKEKVKLSNKDKKRLDDARQRLEGKAGWKKGKAEREAPKPAKGKGKGKDKKKGKN
What is the function of this protein?
ATP-binding RNA helicase involved in ribosome assembly.
What are the official names of this protein?
ATP-dependent RNA helicase drs1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HTPX_PSEA6
Sequence: MFRILMFLATNIAVMVLISLVFSLFGFQGLLAQNGVDLDLQALLVYSAVIGFSGSIISLLISKFMAKRSMNVHVLEHPENDTERWLLRTVERQAEQANIGMPEVGIFVHASPNAFATGWNKNNALVAVSTGLLENMTQSEVEAVLAHEISHVANGDMVTMTLIQGVLNTFVVFLSRVIGHVVDRVVFKVERGHGPAFWIVSIISQVILGILASMIVMWFSRYREFRADAGGASIAGRNNMIAALKRLKQNQDAPPMPEEMAAFAISAGKVQKLFSSHPPLDKRIEALQKG
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.