PharMolix/UniProtQA huggingface dataset:
Protein: NAP1C_TOBAC
Sequence: MSNAKDNFNVADLTAALNAEDRDDLVNVLKNKLQGLTGKHSNVLENLSPNVRKRVEVLREIQTQHDELEAKFFEERAALEAKYQKQYQPLYAKRSEIVNGVVEVDGEATQTAAADEEEDKDSVEKGVPDFWVTAMKNNEVLAEEITERDEGALKFLKDIKWSRIENPKGFKLEFFFETNPYFTNTVLTKTYHMIDEDEPILEKAIGTEIEWHPGKCLTQKILKKKPKKGSKNSKPITKIEQCESFFNFFSPPQVPDDEEDIDEDAAEELQNLMEQDYDIGSTIRDKIIPHAVSWFTGEAAQDEDYIDLEDDEDEEDDEDEDEDEEDEEEEDEDEDDDDEDEHVTKTKKKSSAGRKRSGGAPAADGQPGERPPECKQQ
What is the function of this protein?
May modulate chromatin structure by regulation of nucleosome assembly/disassembly (By similarity).  Could function together with B-type cyclins in the regulation of microtubule dynamics.
What are the official names of this protein?
Nucleosome assembly protein 1;3, NtNAP1;3, Nucleosome assembly protein 1-like 3, NtNAP1_L3.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: HES2_MOUSE
Sequence: MRLPRRVEDAAELRKNLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRSSKLEKADILEMTVRFLQEQPATLYSSAAPGPLNSYLEGYRACLARLARVLPACSVLEPAVSARLLEHLRQRTVSDDSPSLTLPPAPAPAPSPPVPPPGSSGLWRPW
What is the function of this protein?
Transcriptional repressor of genes that require a bHLH protein for their transcription.
What are the official names of this protein?
Transcription factor HES-2, Hairy and enhancer of split 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: TKPR2_ARATH
Sequence: MSEYLVTGGTGFIASYIIKSLLELGHTVRTTVRNPRDEEKVGFLWEFQGAKQRLKILQADLTVEGSFDEAVNGVDGVFHTASPVLVPQDHNIQETLVDPIIKGTTNVMSSCAKSKATLKRIVLTSSCSSIRYRFDATEASPLNESHWSDPEYCKRFNLWYGYAKTLGEREAWRIAEEKGLDLVVVNPSFVVGPLLGPKPTSTLLMILAIAKGLAGEYPNFTVGFVHIDDVVAAHVLAMEEPKASGRIICSSSVAHWSEIIELMRNKYPNYPFENKCSNKEGDNSPHSMDTRKIHELGFGSFKSLPEMFDDCIISFQKKGLL
What is the function of this protein?
May be involved in the biosynthesis of hydroxylated tetraketide compounds that serve as sporopollenin precursors (the main constituents of exine).  Acts on tetraketide alpha-pyrones and reduces the carbonyl function on the tetraketide alkyl chain to a secondary alcohol function.
What are the official names of this protein?
Tetraketide alpha-pyrone reductase 2, Protein CINNAMOYL-COA REDUCTASE-LIKE 6.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_I70A0
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: LKB13_MANHA
Sequence: MEANHQRNDLGLVALTMLAQYHNISLNPEEIKHKFDLDGKGLSLTSWLLAAKSLALKAKHIKKEISRLHLVNLPALVWQDNGKHFLLVKVDTDNNRYLTYNLEQDAPQILSQDEFEACYQGQLILVTSRASVVGQLAKFDFTWFIPAVIKYRKIFLETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNIITVALAIVIIFEIVLSGLRTYVFSHSTSRIDVELGAKLFRHLLSLPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLLFSFIFFAVMWYYSPKLTLVILGSLPCYILWSIFISPILRRRLDEKFARSADNQAFLVESVTAINMIKAMAVAPQMTDTWDKQLASYVSSSFRVTVLATIGQQGVQLIQKTVMVINLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTEQYQGKLSLPEIKGDISFKNIRFRYKPDAPTILNNVNLEIRQGEVIGIVGRSGSGKSTLTKLLQRFYIPENGQVLIDGHDLALADPNWLRRQIGVVLQDNVLLNRSIRENIALSDPGMPMERVIYAAKLAGAHDFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMQNMQKICQGRTVILIAHRLSTVKNADRIIVMEKGEIVEQGKHHELLQNSNGLYSYLHQLQLN
What is the function of this protein?
Part of the ABC transporter complex LktBD involved in leukotoxin export.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).
What are the official names of this protein?
Leukotoxin translocation ATP-binding protein LktB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS10_STRGG
Sequence: MAGQKIRIRLKAYDHEVIDSSAKKIVETVTRTGASVAGPVPLPTEKNVYCVIKSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDSLMRLDLPAGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RRF_VEREI
Sequence: MTIAEIRKHAATRMDQSIAAFRNNLQKIRTGRANPALLDAVQVDYYGALVPLSQVANVALIDARTISVQPWEKGMGAKIEKAIRDSDLGLNPAAMGDLIRVPMPPMSQERRKEMTKLARNEGESAKIAVRNLRRDANESIKKLVKDKLASEDEQKRAETEVQKFTDKHIAEIDALVAAKEQEIMAL
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOG_CALJA
Sequence: MASLSKPSLPSYLCFLLLLLHVSSSYGGQFRVIGPSHPIQALVGDAAELPCRISPGKNATGMEVGWYRSPFSRVVHLYRNGKDQDGEQAPEYRGRTELLKDDIGEGKVTLKIRNVRFPDEGGFTCFFRDHSYQEEAAMQLKVEDPFYWVSPGVLVLLAVLPVLFLQITVGLVFLYLQHRLRGKLRAEIENLHRTFDPHFLRVPCWKITLFVIVPVLGPLVALIICYNWLHRRLAGQFLEELRNPF
What is the function of this protein?
Minor component of the myelin sheath.  May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.  Mediates homophilic cell-cell adhesion (By similarity).
What are the official names of this protein?
Myelin-oligodendrocyte glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. BTN/MOG family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GLPK_BURM1
Sequence: MQDQYILALDQGTTSSRAMLFDRQGNIVSIAQKEFEQIYPQPGWVEHDPQEIWSTQAGVAAEAVTRTGLNGTSIAAIGITNQRETTIVWDRETGQPVYNAIVWQDRRTADFCDSLKKQGLEAKVRAKTGLPIDSYFSATKIRWILDNVPGARDKARQGKLAFGTVDSWLVWNFTKHELHVTDVTNASRTMLFNIHTRQWDDELLELLDIPRSMLPEVKASSEIYGHTKTTVFASKIPLAGIAGDQHAALFGQMCTTSGMVKNTYGTGCFLMMNTGDKPIESKNNLVTTIAWQIGDDVQYALEGSIFIAGAVVQWLRDGLGIIKTAAEIEALAASVPHSDGVYLVPAFAGLGAPHWNARARGSLFGVTRGTRDAHLARAALDAIAYQSLDVLAAMEADSGLSIGELRVDGGASANNLLMQFQADLLGVDAVRPQITETTALGAAYLAGLAIGYWKNLDEVRSQWQLDRRFAPSMPKQQVERCMAGWQRAVRAAKAWADDAQ
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: LIMA1_RAT
Sequence: MESTPFNRRQWTSLSLRVTAKELSLVNKNKSSTIVEIFSKYQKAAEEANMERKKNNTESLPQHFRRGTLSVLKKKWENPVAGAESHTDSLPNSSSDGGHTADHPPAEVTAKAAPGARADREEHTQPRSRFGSRPEAVTQCRYPRSEDSHDFKAQATESQNMENCLGDSRHEAEKPEMSENTETSGKIEKYNVPLNRLKMMFEKGEHSQNKSPWTQGRNAGGRRLSENSCSLDDLEIGAGHLSSSAFNSEKNESKRNLELPRLSETSIKDRMAKYQAAVSKQSSPASYASELKPSESKTHKWEQKENVPPGPEACSIHQEGSKVSATENSLVAHPVPAEDDTCNSQGRSEAQQPIYTKPLSPDARTSSLPESSPSKTAKKFQAPARESCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHKQHKDLWASKGENEETLGRPAQPPSAGETPHSPGVEDAPIAKVGVLAASMEAKASSQREREENKPAETKKLRIAWPPPAEQGSSGSAPEEGFKVSKPKWPPEDEVCKTEAPEDVDLDLKKLRRSSSLKERSRPFTVAASFRTSSVKSPKPLSPSLRKGWSEPEPEQSEEFGGGTVTQTESPRPSREKESVGKSRWQSEEAEAEAEEAPRGRDGRSFELESESFIGNGASIAEDDVAPAQRSPLEPESPGWPGFGDTTTAKEFNQKSQDVGFWEGEVVRELSVEEQIKRNRYYDEDEDEE
What is the function of this protein?
Actin-binding protein involved in actin cytoskeleton regulation and dynamics.  Increases the number and size of actin stress fibers and inhibits membrane ruffling.  Inhibits actin filament depolymerization.  Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity).  Plays a role in cholesterol homeostasis.  Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption.  May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity).
What are the official names of this protein?
LIM domain and actin-binding protein 1, Epithelial protein lost in neoplasm.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cell membrane. Note=This cytoskeletal protein colocalizes with actin stress fibers and focal adhesion plaques. Expressed mainly in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (By similarity). Colocalizes with PXN at focal adhesions in mesangial cells (By similarity). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity).
Protein: TPIS_LEGPC
Sequence: MRQKIVAGNWKMNGQIQQVTELVSQIEELIGFDCAAQVAVMPPSIYIPKVRDCLRTGRIVVGAQNVYPKDYGAYTGELSAPMLKDFDCRYVLVGHSERRQFFHEDENFVAQKFHHVKDHGMIPILCVGETLSERENGKTEQIIAQQVLAVSAKGKDCFRDCVVAYEPVWAIGTGKTATPEQAQKIHQFIRDLVGEINDSDAKHLTLIYGGSVNENNAKALFSMPDIDGGLVGGASLNAKQFVEIVKCIN
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED8_DEBHA
Sequence: MNSIHSANSNTVSTSEINTSQIPTDSLESIRNRLNQVHLSLRKLSDQINHHNRHPNKVKLPNYAQFQNQFQVLLTQLHTITSDLENNDELLKNTNVYPLPSFPTTQQEGLITTLLRKKPLPEVDEWIESAIDKRKNEYVNVQKDDEFAQWCLTKIEELREDFQFYGFNSVEELKYLDSEDEKKETEENKKIENQKYEEELKITAGGKSGLHPNRVLKFMCQGVLT
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 8, Mediator complex subunit 8.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 8 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BIG1A_ARATH
Sequence: MEITWEKPKSSSHHRNPSFSSTLLDQIYRSIDDSSPPPPLESIKKKKHHHQQRNASLHEDREISPIYHRRSIAADFERSRRKTDFLRHSNSSSSDSSGFSSSESDSFHGRSKSSASPPSSSRQQPKPIRTSSVDHSSAVQKPKELGGFLRTKSKALKIYSDLKKVKQPISPGGRLATFLNSLFTNAATNPKKHKKTTTVAVVEEPHSSSTCSSASSFSRSCLSKTPSSSGKSKRSVRFCPVNVILDEDSSFTMPYAYNNERLYDNNEAKRVEEHRRVIQAAKDLLRTYHNKNKVTTTNINNVEEDDEDDAASCASSDLFELENLSAIGIERYREELPVYETTRLDNMNRVIATGLIV
What is the function of this protein?
Involved in auxin transport.  Regulator of the auxin signaling pathway.
What are the official names of this protein?
Protein BIG GRAIN 1-like A.
What is the protein family that this protein belongs to?
Belongs to the BIG GRAIN 1 (BG1) plant protein family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: ESAB_STAAC
Sequence: MNQHVKVTFDFTNYNYGTYDLAVPAYLPIKNLIALVLDSLDISIFDVNTQIKVMTKGQLLVENDRLIDYQIADGDILKLL
What is the function of this protein?
Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host.
What are the official names of this protein?
Type VII secretion system accessory factor EsaB.
What is the protein family that this protein belongs to?
Belongs to the EsaB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARA_BIFLS
Sequence: MSQNESGTIAIPMYDKDDAVLVLEDGQVYVGEPYGALGETTGEIVFATGMTGYQETLTDPSYDRQIVVQTFPHIGDTGVNSEDPESSRIWVAGYIVRDPSPNVSNWRAEGSLDDDLTKNGIVGLSHIDTRKLVRHLRSAGVMRAGIFSGDALTDQATGALKTIEQLLEDVRNTPQMQGLSLYDEVSTKETYTIEPCGEYEGKEPLYTVAAVDLGIKGMTPHRMAERGCRVHVVPSTITFAEIESLNPDGVFFSNGPGDPEQAGPEIELLRQVLDAGYPFFGICFGNQLLGRALGFGTFKLKFGHRGINQPVKDLTTGKVEVTAHNHGFAVDAPIGKQVDAPFENGKYGKVFVSHIDLNDDVVEGLQCVDIPAFSVQYHPEAAAGPHDAAYLFDRFCELMKNNSKEGK
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: RDH7_MOUSE
Sequence: MWLYLVALVGLWTLLRFFRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEQLRNKTSDRLETVILDVTKTESIVAATQWVKERVGNRGLWGLVNNAGICVFAINEWLKKEDFANILDVNLLGMIEVTLSMLPLVRKARGRVVNISSSMGRVSLCGGGYCISKYGVEAFSDSLRREISYFGVKVAIIEPGGFRTNVSNYERLSHSIEKLWDQTSSEVKEVYDKNFLDSYIKAIQSLTDTCSDDLSVVTDCMEHALTACHPRTRYSAGWDAKLFYLPLSYMPTFLVDAMLYWSSVKPAQAL
What is the function of this protein?
Acts on androgens and retinols, i. e.  has steroid 3-alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities.
What are the official names of this protein?
Retinol dehydrogenase 7, Cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2, Cis-retinol/androgen dehydrogenase type 2, CRAD-2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Microsome. Endoplasmic reticulum.
Protein: YQGF_MYCTA
Sequence: MVPAQHRPPDRPGDPAHDPGRGRRLGIDVGAARIGVACSDPDAILATPVETVRRDRSGKHLRRLAALAAELEAVEVIVGLPRTLADRIGRSAQDAIELAEALARRVSPTPVRLADERLTTVSAQRSLRQAGVRASEQRAVIDQAAAVAILQSWLDERLAAMAGTQEGSDA
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_SALEP
Sequence: MISDIRKDAEVRMEKCVEAFKTQISKVRTGRASPSLLDGIVVEYYGTPTPLRQLASVTVEDSRTLKINVFDRSMGPAVEKAIMASDLGLNPSSAGTDIRVPLPPLTEERRKDLTKIVRGEAEQARVAVRNVRRDANDKVKALLKDKAISEDDDRRSQEEVQKMTDAAIKKVDAALADKEAELMQF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPI2_VANPO
Sequence: MNKKKTKICCIYHPQDEDEEGCTSDHQHDELPESSSSSSSESENDKDLGFDERRKRRVERRRRKLRDNTDSAPNAYEVQPDYSEHRKKMMEKKSNNT
What is the function of this protein?
Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.
What are the official names of this protein?
Type 1 phosphatases regulator YPI2.
What is the protein family that this protein belongs to?
Belongs to the YPI1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BRDT_MOUSE
Sequence: MSLPSRQTAIVNPPPPEYINTKKSGRLTNQLQFLQRVVLKALWKHGFSWPFQQPVDAVKLKLPDYYTIIKTPMDLNTIKKRLENKYYEKASECIEDFNTMFSNCYLYNKTGDDIVVMAQALEKLFMQKLSQMPQEEQVVGGKERIKKDIQQKIAVSSAKEQIPSKAAENVFKRQEIPSGLPDISLSPLNMAQEAPPICDSQSLVQITKGVKRRADTTTPTTSIAKASSESPPTLRETKPVNMPVKENTVKNVLPDSQQQHKVLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDADALGLHNYYDVVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCYKYNPPDHEVVAMARTLQDVFELHFAKIPDEPIESMHACHLTTNSAQALSRESSSEASSGDASSEDSEDERVQHLAKLQEQLNAVHQQLQVLSQVPLRKLKKKNEKSKRAPKRKKVNNRDENPRKKPKQMKQKEKAKINQPKKKKPLLKSEEEDNAKPMNYDEKRQLSLDINKLPGDKLGRIVHIIQSREPSLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKPQAKKVVRSKEELHSEKKLELERRLLDVNNQLNCRKRQTKRPAKVEKPPPPPPPPPPPPPPPELASGSRLTDSSSSSGSGSGSSSSSSGSSSSSSSSGSASSSSDSSSSDSSDSEPEIFPKFTGVKQNDLPPKENIKQIQSSVQDITSAEAPLAQQSTAPCGAPGKHSQQMLGCQVTQHLQATENTASVQTQPLSGDCKRVLLGPPVVHTSAESLTVLEPECHAPAQKDIKIKNADSWKSLGKPVKASSVLKSSDELFNQFRKAAIEKEVKARTQEQMRKHLEHNAKDPKVSQENQREPGSGLTLESLSSKVQDKSLEEDQSEQQPPSEAQDVSKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD
What is the function of this protein?
Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:12861021, PubMed:19794495, PubMed:22901802, PubMed:22922464).  Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time.  In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802).  Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (PubMed:27105113).  Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (PubMed:22570411).  Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin (PubMed:22020252).
What are the official names of this protein?
Bromodomain testis-specific protein, Bromodomain-containing female sterile homeotic-like protein, RING3-like protein.
What are the subcellular locations of this protein?
Nucleus. Note=Detected on chromatin (PubMed:19794495). Excluded from the chromocenter.
Protein: STHA_ERWT9
Sequence: MQKSYDYDAIVIGSGPGGEGAAMGLVKQGARIAVIERYHNIGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHTRLLRSSFADILNHTENVVSQQTHMRQGFYERNHCEIFQGDARFIDANTLEIETHDGSIERLTAEKFVIACGSRPYHPPDVDFTHPRIYDSDSILNLHHEPGHVIIYGAGVIGCEYASIFRGLAVKVDLINTRDRLLAFLDQEMSDSLSYHFWNNGVVIRHNEEFEKVEGVADGVIMHLKSGKKLKADCLLYANGRTGNTDSLSLENVGLEADGRGLLKVNSMYQTAQPNIYAVGDVIGYPSLASAAYDQGRIAAQAMIKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGSLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKNGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IPYR_AGRFC
Sequence: MRIDAISIGKNPPDDINVIVEVPVGGHPIKYEMDKDAGALIVDRFLYTPMTYPGNYGFVPHTLSDDGDPIDVLICNTRPLVPGCVINVRPIGVMIMEDDGGKDEKILAVPAPKLTQRYDKVHNYTDLPEITLKQIEHFFEHYKDLEPGKWVKMGGWQDVDVAKKLIVEAIERYKTQG
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTOGL_PONAB
Sequence: KIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHSSCLNLREDCACKDGTILHRPHSTQCIPEKECACTDSEDQPRTAGEIWNGGIDECALYKCLENGSVIPIEPDCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDATLCEPTIPTCTNGEKLIVGHSPLSCCPQYKCECDPLKCPSISTPECREDQFMIQVQQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVFGQCCPTWHCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIECLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYDCCGTCKNVSCKFHMENGTSVVYVVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKREERICQKVIIKSVIRKQDCMSQSLINVASCDGKCPSATIYNINIGSHLRFCKCCRENGVRNLSVPLYCSGNGTEIMYTLQEPIDCTCQWN
What are the official names of this protein?
Otogelin-like protein.
What is the protein family that this protein belongs to?
Belongs to the otogelin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MEIS2_MOUSE
Sequence: MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMGMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMVMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ
What is the function of this protein?
Involved in transcriptional regulation.  Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex.  Isoform Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding.  Probably in complex with PBX1, is involved in transcriptional regulation by KLF4.  Isoforms Meis2B and Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain.  May be involved in regulation of myeloid differentiation.  Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription.
What are the official names of this protein?
Homeobox protein Meis2, Meis1-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the TALE/MEIS homeobox family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region.