PharMolix/UniProtQA huggingface dataset:
Protein: NUSB_ALKEH
Sequence: MSTSESPNTPGQGRRARARARELALLALYQWQMTGQDLGAIEAQHLEIDPEEPPVEAGDDEHYPRYPHDGLDRPYFRALLHGVPARLNDLDQALEPLLDRPLRTLDPLEKALLRLGAWELSERMDTPWRVIINEAVNLAKRFGAEQSHRYINGVLDKLARGLPLRATEIEADRKRRGR
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RK16_CHLRE
Sequence: MLSPKRTKFRKPHRGHLRGKATRGNKIVFGDFALQAQEPCWITSRQIEAGRRVLTRYVRRGGKLWIRIFPDKAVTMRPAGTRMGSGKGAPDYWVAVVHPGKILYEMQGVSETIARQAMRIAAYKMPVKTKFLTKTV
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CHEB1_RHIL3
Sequence: MSAPARVLVVDDSATMRGLITAVLSSDPEVNVIGQAGDALEAREAIKRLNPDVLTLDIEMPNMNGLDFLEKIMTLRPMPVIMVSTMTHRGAEATLAALEIGAFDCVGKPAPGELRPFGDLAEKVKAAARTQRQYSQPVVAVAPPPSVADFRVGRKIVAIGSSTGGVEALIAVLQKFPANCPPTVITQHMPPTFTKSFAERLNRLCAPVVQEATDGARLEIGKIYLAPGGERHLQVSGASAPCCRLIDRAPVNGHRPSVDVLFDSVAELAGRNAVGVILTGMGRDGAAGLLKMRHAGARTLGQNEKTCVVYGMPRVAHELGAVEQQLPLSAIGEEILKMTAARKEGTE
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 1.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_SULDN
Sequence: MANKRVLVKFSGEALAGEAGYGIDTKILNFISQEIKSLVEANIEVGIVIGGGNIIRGVTAAQDGIIKRTSGDYMGMLATVINGIAMQEACEHAGLQVRMQTAIKMEQIAEPYINRRAVRHLEKGRVVIFAAGTGNPFFTTDTAATLRAVEIGAEVIIKATKVDGVYDKDPNKFSDAIKLQELSYEQALNDNIKVMDDTSIALAKDNSLPILVCDMFKKGNLLDILQNGNMKNCSIVK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_RHOOB
Sequence: MHCPFCRHPDSRVVDSREADEGQAIRRRRSCPECGRRFTTVETAVLSVVKRSGVTEPFSREKVVRGVRRACQGRQVDNDALNLLAQQVEDAVRASGSAEIPSNEVGLAILGPLRDLDEVAYLRFASVYRSFSSAEDFAREIKELREHRESRDDA
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: KMO_CYTH3
Sequence: MKEQITICGAGLVGSLLAVYLIERGFSVRVFEKRKDPRKNEADAGRSINLAISHRGIHALKDAQTGLEKEALKLAVPMYGRAIHDLHGHVSFQAYGEASQHINSIGRGALNKLLITTAENLGVHFLFEHTCTDYHAAGEQWLFSDITGNTVATQSKEIVIGADGAFSIVRSFLSKQQQPQPQIETLEYGYKELEIASAHTETITNNQALHIWPRERFMLIALPNEDGSYTATLFLPLKGEISFEALQSDQDIQLFFKKYFPDTENLFPDLTEQFYRHPTSKLFTIHSSNWFNAHTLLIGDAAHALVPFYGQGMNAGFEDCRILAEIIDGKSKTNWSEIFAEFYNQRKENADAISDLALQNFIEMRDHVADASFLLRKKIEKHLHQELEDAFIPQYTMVSFTDISYKEAMETGLLHQKILDEIMAIPDIEAAWPTEELKNKVITVTKKYI
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Protein: NH217_CAEEL
Sequence: MCRSVSNMLDRISGLSKDASPNSTTTIQEIITLEKCLTSKVSALFLICKMLKIPACPVCDVPCRIEPHFGGIACAACAAFFRRTVSLNIGYMCKREKLCRKARKSCRACRFERCVKSAGLQRDYVRQLLTPRNTPLYILNRQDNTGGEIVRAFASPTMPKPEPTPQLGFSDILKVSNSSLFKFYLNQVEKAVKLRQKNTLTIKTNAELLKIVATQQELALEACRTCPGMDLLDKEDRKVVQKYFVFSNVWIESTWLYSLAKEHLETENNLNFDINLKKFIEQVKSTLLFSFSQFKLNIFELAAFKAICIWKLIYHETSRAMKIIAQEHYDGVASALRNYYETHTSMDHSEIAIRIGEITLLVVSIFQLYHDMAKLYVQIGIPF
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-217.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RHTC_SALTI
Sequence: MLMLFFTVAMVHIVALMSPGPDFFFVSQTAVSRSRKEAMMGVLGITCGVMVWAGVALLGLHLIIEKMAWLHTIIMVGGGLYLCWMGYQMLRGALKKQDAAASSPHIELAQSGRSFLKGLLTNLSNPKAIIYFGSVFSLFVGDNVGAAARWGIFALITLETLAWFTVVASLFALPKMRRGYQRLAKWIDGFAGALFAGFGIHLIISR
What is the function of this protein?
Conducts the efflux of threonine.
What are the official names of this protein?
Threonine efflux protein.
What is the protein family that this protein belongs to?
Belongs to the Rht family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACYP_MYCSS
Sequence: MSAEPEVRLTAWVHGRVQGVGFRWWTRSRALELGLTGFAANKPDGRVQVVAQGSREDCERLLGLLEGGDTPGRVDKVIADWSDAREQITGFHER
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: CALX_ARTBC
Sequence: MRLNAQLASLLLSSIVLVGSAHGADEEPVAEKKEASSIERPTFVPTTIKAPFVEQFTDKWDSRWSVSHAKKEDAKSDEEWAYVGEWSVEEPTVFKGIEGDKGLVVKNPAAHHAISAKFPKKIDNKGKTLVVQYEVKLQNSLSCGGAYMKLLQENKKLHSEEFSNASPYVIMFGPDRCGATNKVHFIFKHKNPKTGEYEEKHLKAPPAIKVTKLTSLYTLIVNPDQTFQIRIDGEPLKNGTLLEDFTPPVNPPKEIDDEKDTKPADWVDEEKIPDPEAKKPEDWDEDAPFEIVDTEATKPADWLDDEPTTIPDPEAVKPEDWDDEEDGDWIAPTVPNPKCEEGSGCGKWEPPMIRNPAYKGKWSAPLIDNPAYKGVWAPRKIPNPNYFEDKTPSNFEPMGAIGFEIWTMQNDILFDNIYIGHSIEDAEKFKAETYDIKRPIEEAEEEASKPKLSPQIDDETDISFTQDPIGYVRAKIDRFISLAQDDPIAALQAVPEVGGAIGAILASLLIIIGMFGLSSPAPPAKSTGKTAEKTEKEKTTEAVTASGADSGQGEAKKRAAKSG
What is the function of this protein?
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum.  It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits.  It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.
What are the official names of this protein?
Calnexin homolog ARB_00147, Allergen Pen ch 31 homolog.
What is the protein family that this protein belongs to?
Belongs to the calreticulin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: TRMA_SODGM
Sequence: MTPETLPIDQYEQQLAEKAARLRQMMLAFQAPEAQIFRSQPAHYRMRAEFRIWHDEDDLYHIMFDPQTKARIRIDHFMPGSPLINALMAEMMTAIRPEPLLRAKLFQIDYLTTQSGEAVVTLIYHRPLDDAWRECAAGLRDALRARGYHIQFIGRANKTKIYLDRDYVDERLTVAGRTLIYQQIENSFTQPNAGINVHMLEWALAATEGAQGDLLELYCGNGNFSLALARHFDRVLATEIAKLSVEAAHYNIAANHIDNVQIVRMSAEEFTQAMRKEREFTRLKEIDLQSYRCETIFVDPPRSGLDEATVSMVQAYPQILYISCNPDSLCRNLSTLSTTHTIERLALFDQFPYTHHMECGVLLVRKATAV
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: PUS5_CANGA
Sequence: MSARLKVVYDGMHYMIVYKSAGVLSQPGLASDSRPVLMSELRGLLSETLDLYSVQRLDACVTGGTVVAKNKRAAMMFSRYLKQGGGSGYGLTRRYLARINAQPVCDEGTIESPGMVTYYRRVRDDCVVVELKTGKKHQIRKHLALNLNCPIVNDTYYGGSVVKGVNGQIALHSAFVRTRIGKNMQDHLVGIEPQEQTLWKSILTENGMLPDDIVRTLTRDKLF
What is the function of this protein?
Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA.  May modulate the efficiency or the fidelity of the mitochondrial translation machinery.
What are the official names of this protein?
21S rRNA pseudouridine(2819) synthase, Pseudouridine synthase 5, Pseudouridylate synthase PUS5, Uracil hydrolyase PUS5.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EFTS_CHLP8
Sequence: MSQISAKDVKELRDTTGVGMMECKKALEETGGDMQKAVEYLRKKGAAMAAKRADREASEGAVCILMSDDQKTGVILELNCETDFVARGEVFTGFANELAELALANNCESREDLLAINLGEAYGNEKVEDALKSMTGKVGEKLELKRLAMLKAEDGVLESYIHPGSQLGALIAVETDKPEETKALAKDLAMQVAAASPIEVGRDAVPAELVEKEKEIYRQQALAEGKKEEFVDKIVMGRINKYYQEVVLTEQTFIKDQNARVSGVLDDFMKKNQAQVKIKAFVRYQLGA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_ECO45
Sequence: MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAESARELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRQGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIRGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDFIRITPPEKLKFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARISQPG
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_ACIBY
Sequence: MIEVVDGQRKLSECKRIVVKIGSSLLTANGQGLDLDAISHWAKQIADLHNAGHEIILVSSGAVAEGMVRMKLASRPTDLPSLQACAAIGQMGLIHTWSSVLENHSIRTAQVLLTHDDLADRRRYLNSCDALQNLIDWRVIPVINENDTVSTDEIRFGDNDTLAAMVAGQVHADLLIILTDQQGMFDSDPRHNPDAKLLSTVRAMDDVLFEMAGGGGVLGRGGMVTKVRAARLAAKSGCPTLIASGESDNVLSRVMAGEMLGTLFTTDKDRMTAHQQWLAAHLQTAGRLVIDDGAVEAIKLKHRSLLPVGVKTVEGHFDRGDVVECVDKQGKRVAVGRVNFSSRSAEIIKGLSSDKVYQVLGEARSLEMIHRDHMAIY
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODO2_PSEPU
Sequence: MHNIIQRPMAINGQVVIRPMMYLALSYDHRLIDGKEAVTFLVTIKNLLEDPSRLLLDI
What is the function of this protein?
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex component E2, OGDC-E2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: MRAZ_YERE8
Sequence: MFRGATMVNLDSKGRLAVPTRYRDLLNEESQGQMVCTIDLHQPCLLLYTLPAWEVIEQKLSRLSSMNPAERRVQRLLLGHASECQMDGAGRLLIAGTLRQHAGLNKEVMLVGQFNKFELWDEQTWYQQVKDDIDAEQSTQEPLSERLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL23_CAMHC
Sequence: MADITDIKTILYTEKTLNLQEGGMVVIQTSPKMTKTSLKAVLKEYFGFTPLKINSLRIDGKVKRFRGRLGVRDNFKKFYVKLPEGVSLENVGA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: ERF1_ORYSJ
Sequence: MCGGAIIHHLKGHPEGSRRATEGLLWPEKKKPRWGGGGRRHFGGFVEEDDEDFEADFEEFEVDSGDSDLELGEEDDDDVVEIKPAAFKRALSRDNLSTITTAGFDGPAAKSAKRKRKNQFRGIRQRPWGKWAAEIRDPRKGVRVWLGTFNSAEEAARAYDAEARRIRGKKAKVNFPEAPTTAQKRRAGSTTAKAPKSSVEQKPTVKPAFNNLANANAFVYPSANFTSNKPFVQPDNMPFVPAMNSAAPIEDPIINSDQGSNSFGCSDFGWENDTKTPDITSIAPISTIAEVDESAFIKSSTNPMVPPVMENSAVDLPDLEPYMRFLLDDGAGDSIDSLLNLDGSQDVVSNMDLWSFDDMPVSDFY
What is the function of this protein?
Probable transcriptional activator that may be involved in defense signaling pathway.  Binds in vitro to the DNA sequence 5'-AGCCGCC-3' of the GCC-box element found in pathogenesis-related (PR) gene promoters.  The transcriptional activation is enhanced in vitro by the presence of MPK12/BWMK1.
What are the official names of this protein?
Ethylene-responsive transcription factor 1, Ethylene-responsive element-binding factor 1, EREBP-1, OsEREBP1.
What is the protein family that this protein belongs to?
Belongs to the ethylene-response factor family. Class 1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTHP_STAAN
Sequence: MEQNSYVIIDETGIHARPATMLVQTASKFDSDIQLEYNGKKVNLKSIMGVMSLGVGKDAEITIYADGSDESDAIQAISDVLSKEGLTK
What is the function of this protein?
P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes.  Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources.  P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity (By similarity).
What are the official names of this protein?
Phosphocarrier protein HPr, Histidine-containing protein.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOF_XANOR
Sequence: MARPDLHGRISSLRKLHVAQDRVRVRRQVGRRDGVRLEIDGRWLTGFCSNDYLGLSQQFEVIAALQDAAARDGAGATASHLICGHHTAHETLEREIAEWLGYPSALLFGNGFIANLAVQQALLSEEDDVCVQDRLNHASLLDATRLAGCRLRRYPHLDVEGAMRQLKGAPEGAAMLASDAVFSMDGDVAPLRALSLVARMQDALFYVDDAHGVGVLGPQGRGCVADAGLGVAEVPLQLVTLGKALGGYGAVVVGDDALVRHLAETARPYIYTTALPPAQVAATLAAVRLARRDDWRRARLVELIAAFRDGARKHGFELMASDTPIQPLLCGEEATVMAMSAALEQAGFMVGAIRPPTVPEGKARLRVTLSALHTPQQVQALIDAIVQARDVVSRQPLRASA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: TCAL3_HUMAN
Sequence: MEKPYNKNEGNLENEGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPGDEGQLEDEGSQEKQGRSEGEGKPQGEGKPASQAKPESQPRAAEKRPAEDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRKKQKMGGFHWMQRDVQDPFAPRGQRGVRGVRGGGRGQRGLHDIPYL
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Transcription elongation factor A protein-like 3, TCEA-like protein 3, Transcription elongation factor S-II protein-like 3.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family. TFA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: METK_MYCMS
Sequence: MNQNIEKRLFTSESVSEGHPDKICDQISDAILDEVLKQDKNAKVACEVFATTNYLLIGGQISSTAIVNYEQVARDVLKKNGYVDDAYGINANTCKIDIKIESQSPDIAQGVELSNDQIGAGDQGIMFGYATNESKTYLPLAITIAHELVYNATSQRKKGLFKWARPDMKSQVTIDYTNINNPKIDTILMSIQHDPNYNETEFKKYIKENIMNLVAKEFNLNTDFKVLINPTGRFVIGGPQGDTGLTGRKIIADTYGGYSRHGGGAFSGKDSTKVDRSAAYMCRYVAKNLVAAGLADKIEIQVSYAIGISQPISIFIETFNTHKVDLNTIYKAVYENFDFSVSSMIKTLDLKKPIFFKTSKYGHFGKKDLPWEKLDKIEVLKEYKKCS
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_HAEIG
Sequence: MSLFALFYMLFAYLLGSISSAILICRIAGLPDPRQNGSHNPGATNVLRIGNRKSALAVLIFDMLKGMIPVWAGYYLGLTQFELGMVALGACLGHIFPIFFQFKGGKGVATAFGAIAPISWAVAGSMFGTWIFVFLVSGYSSLSAVISALLVPFYVWWFKPEFTFPVALVCCLLIYRHHDNIQRLWRGQEDKVWAKFKKK
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDE3A_HUMAN
Sequence: MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ
What is the function of this protein?
Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:8695850, PubMed:8155697, PubMed:25961942).  Has also activity toward cUMP (PubMed:27975297).  Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway.  E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity.  This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099).
What are the official names of this protein?
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A, Cyclic GMP-inhibited phosphodiesterase A, CGI-PDE A, cGMP-inhibited cAMP phosphodiesterase, cGI-PDE.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cytoplasm, cytosol.
Protein: TIP_THEKO
Sequence: MDRKLDEFIGDATPKKVSKEKPVRRKKRLKPTSLDSFLPEEHINYFRDLRIGSKKIRNAKIEEL
What is the function of this protein?
Binds to the DNA polymerase sliding clamp (PCNA) and dissociates the PCNA trimeric ring, leading to the inhibition of PCNA-dependent activities (PubMed:24728986, PubMed:27141962).  In vitro, inhibits the PCNA-dependent activities of DNA polymerase PolB and of flap endonuclease 1 (FEN-1) (PubMed:24728986).
What are the official names of this protein?
PCNA-inhibitor, Thermococcales inhibitor of PCNA, TIP.
Protein: CLPP_SHESW
Sequence: MHNASDIQNALVPMVIEQTAKGERSYDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLESESPDKDIFLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKRFCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLNLMLAEHTGQPLEVIERDTDRDNFMSATQAVEYGLVDSVMTKRG
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLD_SALPA
Sequence: MNKILLQCDNLCKRYQEGTVQTDVLHDVSFSIGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFSGQPMSKLSSAAKAELRNQKLGFIYQFHHLLPDFTALENVAMPLLIGKKKPAEIDARAREMLHAVGLEHRATHRPSELSGGERQRVAIARALVNNPRLVLADEPTGNLDARNADSIFELLGELNRLQGTAFLVVTHDLQLAKRMSRQLEMRDGRLTAELSLMGAE
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL17_MYCMM
Sequence: MPKPTKGPRLGGSSSHQKALLANLATSLFEHGRIKTTEPKARALRPYAEKLITHAKKGALHNRREVLKKIRDKDVVHTLFAEIGPFFADREGGYTRIIKVEPRKGDNAPMAVIELVREKTVTSEADRARRVKASQAASQDAPSEPQAAEEPAAEEAVAATEAVAAPADAEATDAEAGSADADADEAPQN
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.