PharMolix/UniProtQA huggingface dataset:
Protein: NCAP_I83A5
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDHEGRLIQNSITIERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGIGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTASQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVVPRGQLSTRGVQIASNENMDAIDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMENARPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: PRIM_EBVB9
Sequence: MSAPVVIKALVASNTDIAEAILDAILSRPDEGFRLFCLCHNASPLHHVAGSLVELQLHLPKKRLTSQSRCGLVLTLHLPAEEAFPFLRGLTPLTADRLSTYLDRAGALRSLTPLVELLTLSAKKQPQGDARGRVAWLRPKIVGCLRRIYRVNISARWFISTFGSHEAQFVLVTAAYYFWGIPCTIETLAHLTELFTSESGQSLAAVTSLAELGEVFGSSAWAEQTEAFAHFAHEKLRRDSREIRAVARTIDAYRGRLPLASADLVRYVYLAHAQCFNEGTFKRYSQLTSMGEIGCLPSGGVVLPSLLDRGFAEHMRTYFTRETYLAEHVRVQQLKIRMEPPAPYTWDPDPDDGLMRAWAGLSVDVARELVELARWHADEGPTYPPTLQGFLCLAGQATCRGQWNPKEQFLPPTVLRRVQRLPVFLCHFADRHYFVMTAADPFSSHLAEVVSTPTNCRLPDTCLTRALSYTPVYYSQNSLSEQLFVSRHEYFNPRLPVCNLVLDLDLKIKGAPWSLEEIYDLCRTVRREVLRLMRRLGPVSRAHPVYFFKSACPPADPDNMEDVLPFCICTGKLGFRVITPLPRGHAIVGTSAVQGFVSVLQKLMGLTACLRRMRHKIKEIGAPLFDSGVYHAGRCIRLPHTYKVDRGGGLSRQLRLFVCHPEEEDKHSYVKNALNIQNLLHHSLHVGWPAPKTFCYHIADDGRDYLIQRTRETLPPTVENVCAMIEGHLGLDLVAWVSSCIWPSLMSTLATAVPEDKFPQFLHVTFEQTGPNLVQVCHARGRNFACLRHTHRASSKNVRVFLVLYYTSQAITVTFMSQCFAGRCGANQPTAHFSISVPASRIINRAEASQDSTTSQLARRRDRQDGSFSETLPN
What is the function of this protein?
Essential component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA primase family.
What are the subcellular locations of this protein?
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Protein: SYDND_BORGP
Sequence: MFKVIKCNELNEKLINKKVEINAWVKKIRHHGKFIFLNIRDRYEKAQVLITEEHLLKIAEKIKLEYCIKIQGLLSKRPPNMINENMKTGSFEILAKNIEIISKCNELPFMIEDDNNASENSKLKYRYLDLRRDSLKNKIILRCQATHLIRNFLVKKKFLELETPTFVKSTPEGARDFVIPSRIHKGSFYALPQSPQLYKQLIMIAGFDKYFQIARCYRDEDSRGDRQPEFTQLDLEMSFVKKENIFKLIENMLFLIFKNCLNIKLPKKFKKITYKTAMNKYGSDKPDTRFELTLQDISRNLKNSEFNVFKETLKNKGSIKILIVKDEADKFSRAKINNLEEIAKLYKTQGLYFAKIENNKFSGGIAKFLKTEEQQLIKTYSLENNDIIFFTANKKWETACKAMGQIRIKIANDLGLIDENKFEFLWVYDFPLFEYDENTKTYTPAHHMFSLPKKRYIASLEKIPNKTIGEIYDLVLNGVELGSGSIRIHNKELQQRIFNIIGFQKEKSEDRFGFFLKALEYGAPNHGGIAIGIDRLIMLMTKSTSIKDVILFPKNSFATSPLDDSPSKISNEQLKELGINIVTDDA
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAN3_NEOFI
Sequence: MASAGKPALDDSRRGTGSPKIKARENAKDTLCRNITIYGRCRYEDKGCAFNHDPHKVNSSYQSDSKKRFNVDSPSFTPSLLSSNGSSPTSTPATTKKMTTISPKAANAAPFQPRSVVSRSNASTPGLRQDTVTPDWTVAEVQEFVPQGFDNSHLATLQGNGNGPITSTSPFDPFVTTSTPLSAGGAVGPVQPNPYSHDTAAALGGAAFFPGAAGFQQPVQYHLYAPIGPHSQNTLGYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQIDYFHSLVPLDLNHQKNATIFGFPSWVYKAQSSKDGNFYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTVHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLGAGQQRFQGRQNVHIPEQILWGYMTQIANALKAIHSNGLAARVIDASKILLTGKNRIRLNACAIMDVVQFDSQRTVTDLQRQDLVNFGQLIVTLGANSPTVMHNPTKAMEHFTRAYSPQLKNSVFWLLNGMQKDQDRNIDIFITGISSQLMSTFDSALHLDDQLTSDLSRELENGRLVRLMTKLNFVNERPEYEHDRQWSENGERYFLKIFRDYVFHQVDVQGDPVVDLGHVISCLNKLDAGTEEKITLISRDEQSCFIVSYKELKKALESSFQALMKPARRMH
What is the function of this protein?
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.  pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex subunit PAN3, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. PAN3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG8_LACBI
Sequence: MRSKFKDEHPFEKRKAEAERIRQKYPDRIPVICEKADRTDIPTIDKKKYLVPSDLTVGQFVYVIRKRIKLAPEKAIFIFVDEVLPPTAALMSAIYEEHKDEDNFLYVSYSGENTFGQEGWVELPVDDMDKAFICVSAAKKHWVWVLCDVRSSYQNCVLIVPLVQRPVLHTHSSFLSVSFALLFV
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Participates also in membrane fusion events that take place in the early secretory pathway.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
What are the official names of this protein?
Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier ATG8.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor.
Protein: KHSE_SALCH
Sequence: MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDVVSVEAADHFRLHNLGRFADKLPPEPRENIVYQCWERFCQALGKTIPVAMTLEKNMPIGSGLGSSACSVVAALVAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENGIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPQLAAALMKDVIAEPYRARLLPGFSQARQAVSEIGALASGISGSGPTLFALCDKPETAQRVADWLSKHYLQNQEGFVHICRLDTAGARVVG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_PARXL
Sequence: MRSVIADSRRLVVKVGSSLVTNDGRGLDHAAIGRWAGQIAALRAQGKEVVLVSSGAIAEGMQRLGWTRRPREIDELQAAAAVGQMGLAQVYESRFAEHSIQTAQILLTHADLADRERYLNARSTLLTLLRLGVVPIINENDTVVTDEIKFGDNDTLGALVANLIEGDALVILTDQQGLFTADPRKDPAATLVQQADAGAPELEAMAGGAGSSLGRGGMLTKILAAKRAAHSGANTVIASGREVDVLSRLASGEAIGTQLIARTARMAARKQWMADHLQVRGHVVIDDGAVEKLTEGGKSLLPIGIVGVQGAFARGEVIACLSAAGREVARGLTNYSSAETKLIQRRPSGEIESVLGYMLEPELIHRDNLVLV
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP2_ROTB2
Sequence: MEVIEKLETIRETLNDTKDKKDFQKIHDELVQYLDGVDSLTIDDDKWNEILKLFKTIIIKLKSSTIKTTPLENELLQHEKKRTVKEVEKVEEDIKTDVTNDTSKPTLMDKVLQVSNQPNNPYSADVLQIRTILSKTLFVDTDSEAYSLYVPESQKLDVSPITIELTTIEKYQPKVNILKQAVIVPSQNPLLADTYGAPEILFSTDFFDDITSNSSEGLQLYFFDKAYKLKKELPNLPFLSSLDKDVNPLNPLNSVCKSFGQEKYYDMVMDRTDRGLDARRAAMQFDNVIVDAQNRTVQFNVRMHPFDLQLLRISQQFAEPMQDLAPVVREYMMLGADGYVLTQKIRLDRDQQLIANRRSVVFDRMCELSGPLYRSRIIHSMRMMSKLWRTNVFRTSLEDEITKIYAAAEVSMISIDATTSALSTINIASAEQTLNALLNMSFFRCELDLIGSQSSFGAAMSAMIALMILPTDQENMDDEVFDVLCNLVYNELIAWAADRPVFVRRAGATNAFRQFVNAGLNRDITNYMRFVLLRRPWLPLYNSRDVRRNAHVLVPNVDLANINDQVYVAINSFLNGIIEASRRNPNPNKTISANSFRKLMKNMRDICVNRLMPVIRLIRYNVERIGMILHMLPYSADIFDINRNLRDERLRIKIPMSGFLSLVMGITKAPDAFDWSQILNFADDVRKMDYAEAISIEDSASVAIMRNDANRATSKKEIFISEVRPPTPTVASIQKIPSATLTAIFSDRQLINLIRDTHSFRVIREIAVALQAAFDNSPTSQHGVGKGAVLHPVPQNFGRSSQFVRRDNILLQRPAGIQQFTIEDLKQGRYFQGLMAQIRARQPIIVNGPIPLRISDAAEIEQVTLAFLTMNSPYDAYIDPRDLKQQKLLTDREVDLFIDQSPARPNDEFDNVMARTSVFIIDAPRAIVPINPQRLNFPYHDIMVTDSVTKFIEFTVALTPDLQLFNGLLVFEQ
What is the function of this protein?
Inner capsid protein that self-assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices.  This capsid constitutes the innermost concentric layer of the viral mature particle.  It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels formed by VP2 N-termini.  VP2 is required for the replicase activity of VP1 polymerase.  Probably recruits a copy of a VP1-VP3 complex, potentially along with a segment of plus-strand RNA, as a decamer of VP2 assembles.  May activate the autoinhibited VP1/RNA complex to coordinate packaging and genome replication.
What are the official names of this protein?
Inner capsid protein VP2.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP2 family.
What are the subcellular locations of this protein?
Virion. Note=Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: TRPV6_RAT
Sequence: MGPLQREGRPALGDANVAPGSSPGGVWHQPQPPKDSAFHPMGWSLPKEKGLILCLWNKFCRWFHRRESWAQSRDEQNLLQQKRIWESPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELIVTTKKREARQILDQTPVKELVSLKWKRYGRPYFCVLGAIYVLYIICFTMCCVYRPLKPRITNRTNPRDNTLLQQKLLQEAYVTPKDDLRLVGELVSIVGAVIILLVEIPDIFRLGVTRFFGQTILGGPFHVIIVTYAFMVLVTMVMRLTNSDGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYPMALFSTFELFLTIIDGPANYDVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIRRYAQAFQQQDDLYSEDLEKDSGEKLEMARPFGAYLSFPTPSVSRSTSRSSTNWDRLRQGALRKDLQGIINRGLEDGEGWEYQI
What is the function of this protein?
Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:10428857, PubMed:11287959, PubMed:27296226, PubMed:28878326).  Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity).  The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:10428857, PubMed:11287959, PubMed:27296226).  Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation.  In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner.  Heteromeric assembly with TRPV5 seems to modify channel properties.  TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
What are the official names of this protein?
Transient receptor potential cation channel subfamily V member 6, TrpV6, Calcium transport protein 1, CaT1, Epithelial calcium channel 2, ECaC2.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RRP4_METTH
Sequence: MLLVNEKDLVVPGQVLAENEYFPGRGTFKEDNRICSSFVGLVSVRNKKINVIPLQSKYIPKRGDVVIGEITDIRFSMWGLDINSPYTGLLPASEVFGKDKRELESVFDIVDVLLLRVVDVDEVKKVKLGLKGRGLGKFRDGILVYITPTKVPRLIGKRGSMINMVKEKTHCDIVVGQNGVVWIKGEPDMERIAEKVVLMIDREAHTSGLTDRVRELLDRLTGVEPEIQVEESEGTEKPETPESEDFEEASDYSEDVEVSPESEDIEEVSDESEDLEVESEDVEEGTDTPAAEEDDGEAGDAEVKDENNSER
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Increases the RNA binding and the efficiency of RNA degradation.  Confers strong poly(A) specificity to the exosome.
What are the official names of this protein?
Exosome complex component Rrp4.
What is the protein family that this protein belongs to?
Belongs to the RRP4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOTB_CITK8
Sequence: MTTNTVSRKVAWLRVVTLAIAAFIFNTTEFVPVGLLSDIARSFAMPTAQVGIMLTIYAWVVALMSLPFMLLTSQVERRKLLICLFVLFIASHVLSFLAWNFTVLVISRIGIAFAHAVFWSITASLAIRLAPPGKRAQALSLIATGTALAMVLGLPIGRIVGQYFGWRTTFFAIGIGALITLVCLIKLLPKLPSEHSGSLKSLPLLFRRPALMSIYLLTVVVVTAHYTAYSYIEPFVQTVAGLSANFATVLLLILGGAGIIGSVVFGKLGNQYASPLISIAIMLLVICLMLLLPAADSESHLAVLSIFWGIAIMVIGLGMQVKVLALAPDATDVAMALFSGIFNIGIGAGALVGNQVSLHWSMSTIGYVGAVPALAALVWSIIIFRRWPVSLEEQPQH
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
What are the official names of this protein?
Probable sugar efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARGC_SHEON
Sequence: MKNIAIIGASGYTGAQLTALVHAESELSIQGLYVSENSLDKGRALADLYPVYSHIELTLSPLTEEAKANIVAEADAVVLATEHSVSLHLAAWFYSQGLAVFDLSGAYRFSDVAQYPKWYGFEHEYPEVLAKAVYGLAEWNAKDVAATKMIAVPGCYPTASLTALKPLKNLLTSAYPVINAVSGVTGAGRKAQLHTSFCEVSLTPYGVLGHRHQPEIATQLGQEVIFTPHLGNFKRGILATITVQLKPGTTTADVAAAYSVYDQAPLVTVKQNQFPKVDDVVLTPNCHLGWKFDESSGYLVVASAIDNLMKGAASQALQCIKIHFNL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y9J5_ENCCU
Sequence: MDCLRKQAEKIPILDAIEKRMNIRKEYALLGISFFCLVIIMATSLGPLITSTVGIIVPLQETLVILRQVNPKKDEAKHMLVFWMVFGILTSLDAYSGAIISFIPLWYTMKFFFLLWAGPLKFRGGIIIYDNILARIPEKWYREEGGIEHAVKKATDAVKTVAESEFNKKDVIESSKKTD
What are the official names of this protein?
Uncharacterized membrane protein ECU09_1950.
What is the protein family that this protein belongs to?
Belongs to the DP1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DISA_BACC3
Sequence: MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: PUR9_STRPN
Sequence: MTKRVLISVSDKAGIVEFAQELKKLGWEIISTGGTKVALDNAGVDTIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHLEAAKDNKIELIDLVVVNLYPFKETILKPDVTYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAVVLDELAANGETSYETRQRLAAKVFRHTAAYDALIAEYFTAQVGESKPEKLTLTYDLKQPMRYGENPQQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDSPTVVALKHMNPCGIGQADDIETAWDYAYESDPVSIFGGIVVLNREVDAATAEKMHGVFLEIIIAPSYTDEALAILINKKKNLRILALPFNAQEASEVEAEYTGVVGGLLVQNQDVVKESPADWQVVTKRQPTETEATALEFAWKAIKYVKSNGIIVTNDHMTLGVGPGQTNRVASVRLAIDQAKDRLDGAVLASDAFFPFADNVEEIAKAGIKAIIQPGGSVRDQESIEAADKYGLTMVFTGVRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: ATPE_RICFE
Sequence: MNETILVKIITPLSIAFEKQAKMVTMPGEEGMFGVLPNHAPMIVSLKAGLVQVYIDDIYNPQITYLVSSGVTEVTGSYVNIATETAINVTNLNEAEIATKLLELQKPLSEQH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: EST1_PSEFL
Sequence: MTEPLILQPAKPADACVIWLHGLGADRYDFLPVAEALQETLLSTRFVLPQAPTRPVTINGGYEMPSWYDIKAMSPARSISLEELETSAKTVTDLIETQQRTGIDTSRIFLAGFSQGGAVVFHTAFKKWEGPLGGVIALSTYAPTFDNDLQLSASQQRIPTLCLHGQYDEVVQNAMGRSAYEHLKGRGVTVTWQEYPMGHEVLPQEIHDIGAWLAERLR
What is the function of this protein?
Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity.
What are the official names of this protein?
Carboxylesterase 1, Esterase I.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Protein: TRPA_HAEIG
Sequence: MSRFETQFATLNAKNEGAFVPFVTLCDPTFDRSFEIICTLVDNGADALELGFPFSDPLLDGPVIQAANNRALTAGHSSEDSFKLLEKVRSKYPEIPISLLLCANLIFAKGLDAFYQRCAEVGVDAVLVADIPLLAKEDYVQAAKKHGIQPVFICPPNADEKTIQGVAENSEGYTYLVSRAGVTSAENQAHAANLDTLVEQLKAHNAPPILQGFGIAQPEQVKEALSLGTAGAISGSATVKIIERNLDNHEQCLAELAEFVQTMKAATK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: IF4G_ARATH
Sequence: MSYNQSRPDRSETQYRRTGRSTGNQQQQQQHRSSSAAGYGKGAGAPGSAPAPSTYPDNSSLSSNRSFKKPGNAQGGGQPRVNLPPVNHPNNHNNGPNAHSRSQVTGEPGVGGPTNPTESFNRNTGPIPKAPTSQSTVMSSKINETPNTAKVAASGDASQAFPLQFGSLGPDLMVPARTTSAPPNMDDQKRAQMQQSSLRTASNVPASVPKKDSSNKGADNQLMRKEGHNPSSEKADIQVPHIAPPSQTQKSPITNIRMPSVQTPYQHTQVPHPVHFGGPNMHMQTPVTATSFQMPMPMALSMGNTPQIPPQVFYQGHPPHPMHHQGMMHQAQGHGFATPMGAQIHPQLGHVGVGLSPQYPQQQGGKYGGARKTTPVKITHPDTHEELRLDRRGDPYSEGDSTALKPHSNPPPRSQPVSSFAPRPVNLVQPSYNSNTMIYPPVSVPLNNGPMSSAQAPRYHYPVIDGSQRVQLINQPAHTAPQLIRPAAPAHLSSDSTSSVKARNAQNVMSSALPVNAKVSVKPAGVSEKLGSPKDRSHGEVNISLSQKNVEACSLSSSQQPKPSFVSGVPNSSAPPAKSPVETVPLAKSSVETVPPVKSSVETAPVTTTEIRRAEMVSESISVEDQTCKVEPPHNLTENRGQTMPDSLVSDPETATVAAKENLSLPATNGFRKQLLKVSTTSDAPTSDSVDTSIDKSTEGSSHASSEISGSSPQEKDLKCDNRTASDKLDERSVISDAKHETLSGVLEKAQNEVDGATDVCPVSEKLAVTDDTSSDLPHSTHVLSSTVPLGHSETHKSAVETNTRRNTSTKGKKKIKEILQKADAAGTTSDLYMAYKGPEEKKESSNVVHDVSNQNLLPAIPQAVEAIVDTEPVKNEPEDWEDAADVSTPKLETADNSVNAKRGSSDEVSDNCINTEKKYSRDFLLKFADLCTALPEGFDVSPDIANALIVAYMGASHHEHDSYPTPGKVMDRQASGARLDRRPSNVAGDDRWTKNQGSLPAGYGGNVGFRPGQGGNSGVLRNPRMQGPIISRPMQPVGPMGGMGRNTPDLERWQRGSNFQQKGLFPSPHTPMQVMHKAERKYQVGTIADEEQAKQRQLKSILNKLTPQNFEKLFEQVKSVNIDNAVTLSGVISQIFDKALMEPTFCEMYADFCFHLSGALPDFNENGEKITFKRLLLNKCQEEFERGEKEEEEASRVAEEGQVEQTEEEREEKRLQVRRRMLGNIRLIGELYKKRMLTEKIMHACIQKLLGYNQDPHEENIEALCKLMSTIGVMIDHNKAKFQMDGYFEKMKMLSCKQELSSRVRFMLINAIDLRKNKWQERMKVEGPKKIEEVHRDAAQERQTQANRLSRGPSMNSSGRRGHMEFSSPRGGGGMLSPPAAQMGSYHGPPQGRGFSNQDIRFDDRPSYEPRMVPMPQRSVCEEPITLGPQGGLGQGMSIRRPAVASNTYQSDATQAGGGDSRRPAGGLNGFGSHRPASPVTHGRSSPQERGTAYVHREFASLSRASDLSPEVSSARQVLQGPSATVNSPRENALSEEQLENLSLSAIKEYYSARDENEIGMCMKDMNSPAYHPTMISLWVTDSFERKDKERDLLAKLLVNLVKSADNALNEVQLVKGFESVLKTLEDAVNDAPKAAEFLGRIFGKSVTEKVVTLTEIGRLIQEGGEEPGSLIEFGLGGDVLGSVLEMIKTEAGEETLVEIRRSSGLRIENFKPHAPNRSKILEKFT
What is the function of this protein?
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.  Plays a role in the accumulation of some potyvirus during viral infection.  Required for the accumulation of cucumber mosaic virus 3a protein and turnip crinkle virus p28 replication protein during viral infection.  These proteins are necessary for cell-to-cell movement of the virus.
What are the official names of this protein?
Eukaryotic translation initiation factor 4G, eIF-4G, eIF4G, Protein cucumovirus multiplication 2, Protein synthesis initiation factor 4G.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4G family.