PharMolix/UniProtQA huggingface dataset:
Protein: BRCC3_HUMAN
Sequence: MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQKSSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQELQQEKEELMQELSSLE
What is the function of this protein?
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097).  Does not have activity toward 'Lys-48'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097).  Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) (PubMed:14636569, PubMed:19202061, PubMed:16707425, PubMed:17525341, PubMed:19261748, PubMed:19261749, PubMed:19261746).  In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690).  Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26195665, PubMed:26344097).  Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193).  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665).  Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097).  Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity).  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).  Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity).
What are the official names of this protein?
Lys-63-specific deubiquitinase BRCC36, BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRISC complex subunit BRCC36.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. BRCC36 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:20656690, PubMed:26344097). Interaction with ABRAXAS2 retains BRCC3 in the cytoplasm (PubMed:20656690).
Protein: GLSA_LEGPC
Sequence: MSSKLLTIQLLEELVHAAELNQEGKTADYIPELANVNQELTAIAVQPLGEKTLAYSNNPLHPVTLQSTGKMIPLIGLLEEFGADQLFEWVKVEPSGDDFASITRLEQFGPKPSNPMLNAGAIALCSRIPGVGEQQFRWLEHWVQKLFNQRLSINPLVFASEKRTGNRNRALAYLLKSRNNLGADVHETLDLYFALCSYEAMLDQMLYLPAVLANRGQDPDTGEQILSIETCKITLAIMATCGLYDETGTHMVKTGMPAKSGVSGYTIAVVPGKAGIVVLSPRVNAKGNSIRGEIMLEGLSKAMGWHFALP
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: NOP9_ARTBC
Sequence: MPREKKKRGRRAEKSQSKRKREDEEVSDSPKRQRTTNEDNDALAGDDYIPLDTHDTEKEQEQGQEDDTPFYGLLDTEEQEYFSKASQTLELNSFEDDDDKRLFIESVYTEAKGKELKIACSQSCSRLMEKLIAMSTPAQVKALFEKFSGHFLHLVQHRFASHCCECLFIRAAPIVTSEMEKPKDKKKDRKQTIETNGEDGELDEPINQKPAMDLFLGVVSELEGNWGYLLTESFASHTIRVLLLILAGEPLADHSNARVLASRKKENVDSITSTAQAELTIRESRQVPAEFNNTLRKMISDLSAGLNSTYLQALATHPIGSPVLQVILSIELGCMGKEKVKDKSSVFRRLIPDDTLETKEEGVNFLNSLFYDPVGSRLLETIVRVAPGKFFKTFYKTVIRERIGSLARNEIASYVVIKVLERVSREDLQSAIESILPEIPSLVQRSRLNVIKTIIDRSTVRSADTTSLAKALESAYGEDGLVRLKTILGVEATDKDAESVKPKAATSAQHLHGSLLAQSMLQAPGGLATMIQTSFLAAPVEILIQIAKNPTASRALQEALKPSKSNTQFRRQLLPRFYGQMCDLSLDNSGSHVADALWDATSDLVFIKQRLAQELADNESALRDSFLGRAVWRNWSMDLYKRKRGEWMSRAKGLDNTRVSAPTADSSAEPAKSKLDLARARYAARAEQQEKPDSREQGPRGKKQALSAPSGLLKAQ
What is the function of this protein?
RNA-binding nucleolar protein required for pre-rRNA processing.  Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity).
What are the official names of this protein?
Nucleolar protein 9, Pumilio domain-containing protein NOP9.
What is the protein family that this protein belongs to?
Belongs to the NOP9 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PYL6_ARATH
Sequence: MPTSIQFQRSSTAAEAANATVRNYPHHHQKQVQKVSLTRGMADVPEHVELSHTHVVGPSQCFSVVVQDVEAPVSTVWSILSRFEHPQAYKHFVKSCHVVIGDGREVGSVREVRVVSGLPAAFSLERLEIMDDDRHVISFSVVGGDHRLMNYKSVTTVHESEEDSDGKKRTRVVESYVVDVPAGNDKEETCSFADTIVRCNLQSLAKLAENTSKFS
What is the function of this protein?
Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition.  Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) in an ABA-independent manner but more efficiently when activated by ABA (PubMed:23844015, PubMed:21658606).  Can be activated by both (-)-ABA and (+)-ABA (PubMed:23844015).  May link ABA and jasmonate signaling pathways by modifying MYC2 transcriptional activity, and regulation of JAZ6 and JAZ8 gene expression by MYC2 (PubMed:27357749).
What are the official names of this protein?
Abscisic acid receptor PYL6, ABI1-binding protein 5, PYR1-like protein 6, Regulatory components of ABA receptor 9.
What is the protein family that this protein belongs to?
Belongs to the PYR/PYL/RCAR abscisic acid intracellular receptor family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane. Nucleus. Note=Localizes at the plasma membrane in the presence of a CAR protein (e.g. CAR1 and CAR4).
Protein: RS14Z_CALS4
Sequence: MARKALIVKQQKPQKYKTREYNRCKICGRPRAYLRKFGMCRLCFRKYAHQGMIPGVKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: SYL_HAMD5
Sequence: MQDIYRHQDIESHVQRHWEQTQTFTVKEDPKKEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSPIDWTKANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQDFTVLANEQVIDGRCWRCDSKVERKSIPQWFIKITAYADQLLDDLDELEHWPEQVKTMQRHWIGRSEGVEIRFPLDHDEKTDLTVYSTRPDTLMGVAFIAIAPDHFFSAEIAKNVPALATFIEECRHIKMAEAETATIEKKGIDTGFFALHPLTGKKIPIWVANFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKAVILLEDGTEPDVQKKPLIEKGRLCHSGEFNGLSYQESCDRIIDKLVDLGTGQRKVNYRLRDWGVSRQRYWGAPIPMITLEDGRIIGTPEDQLPVILPEKTLIKDMINPLKADQDWAKTSVAGQLGIRETDTFDTFIESSWYYARYACPKYDQGMIEKAAANYWLPVDQYVGGIEHAIMHLLYFRFFHKLMRDQGLVDSKEPAKRLLCQGMVLADAFYYNAQNGERVWVSPTEVTVERDNKGQFLNAFDAQGRDLIHAGMSKMSKSKNNGIDPQAIVEKYGADTVRLFMMFASAPEMTLEWQESGLEGAYRFLKRLWRFVFDHVIQGPTQPLKKENLNSTQKNLRRNLHKTIAKVTDDIGRRQTFNTAIAAIMELMNQLYRAPTNTEQDRALIQEACISVIKMLYPFTPHISFILWQHLHQSPDETHPLNIDDSLWPVVDQNALIEDETLVVIQINGKMRAKITVPMNSTQQEVYESALQEPTVIKHLKGITPCHVIYVPNKLLNLVVNNE
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y300_HALMA
Sequence: MELTWYGHSTWHVTVDDTELLIDPFFDNPHTDTDPEELGPDYVLLTHGHADHIGDVDRYEGCGLVATPEVVEYCKDNFGEFNAVGGMGMNLGGTVEIGDAFVTMHRADHTNGMETSYGASGGMPGGFIISDTKPTQVSDAESTTFYHAGDTGLMTEMRDVIGPFLEPDAAAVPVGDHFTMGPMQAAVAVDWLDVDHAFPMHYDTFPPIEIETQDFVNEVKGTGSDADVHVLDGDETFEL
What are the official names of this protein?
UPF0173 metal-dependent hydrolase rrnAC0300.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: UNG_STRMU
Sequence: MEHSAWHDLIKKELPEGYFAQINHFMNEVYAQGVIYPPRDKVFNAIQTTPLDKVKVVIIGQDPYHGPNQAQGLSFSVPDQVPAPPSLQNILKELADDIGQKQSHDLTSWAKQGVLLLNASLTVPEHQANAHANGIWEPFTDAVIKVVNQKETPVVFILWGGFARKKKALITNSIHHIIESPHPSPLSAHRGFFGSKPFSQTNHFLVAQGLEPIDWLK
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU6M_PODAN
Sequence: MNNNYPLFWINEILTNGFVEYILDIFSIMAFLTGIYVILTKNPIVSVLFLILLFGGISSYLNIIGLNFIGLSYIIVYIGAVSILFLFILMLINIRTSELQSNTSNSIPLTIFIGIIFSNFLFPMLPYDIVMLSNFYNNYFSEDFYTIDVNINDNNLNNLYNNVLYFMTSVIWDGSVIDFNHITAIGNIMYTIYNIWLIIASFILLLAMVGSIVITIKQRKI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: FLII_ECOLI
Sequence: MTTRLTRWLTTLDNFEAKMAQLPAVRRYGRLTRATGLVLEATGLQLPLGATCVIERQNGSETHEVESEVVGFNGQRLFLMPLEEVEGVLPGARVYAKNISAEGLQSGKQLPLGPALLGRVLDGSGKPLDGLPSPDTTETGALITPPFNPLQRTPIEHVLDTGVRPINALLTVGRGQRMGLFAGSGVGKSVLLGMMARYTRADVIVVGLIGERGREVKDFIENILGAEGRARSVVIAAPADVSPLLRMQGAAYATRIAEDFRDRGQHVLLIMDSLTRYAMAQREIALAIGEPPATKGYPPSVFAKLPALVERAGNGISGGGSITAFYTVLTEGDDQQDPIADSARAILDGHIVLSRRLAEAGHYPAIDIEASISRAMTALISEQHYARVRTFKQLLSSFQRNRDLVSVGAYAKGSDPMLDKAIALWPQLEGYLQQGIFERADWEASLQGLERIFPTVS
What is the function of this protein?
Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.  May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage.
What are the official names of this protein?
Flagellum-specific ATP synthase.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YR667_MIMIV
Sequence: MTDKSKKSKKLKTQYGSVRYSNFINKAIQLYGCQYTYGEYINMTTRMMIICNQCRDVMYETPKNHLHQKAICQKCHKIPDKPKKYLINTKQKYLEQFAKIYGEKFDFSQFDYQGYYEDAEIICNNCKQKQTFTIRKLLNGTKCSFCAER
What are the official names of this protein?
Uncharacterized protein R667.
Protein: PSAJ_SYNP2
Sequence: MDKFLSSAPVLLTAMMVFTAGLLIEFNRFFPDLLFHP
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: CART_GIBFU
Sequence: MALNGPGVYHRTREHEQKDASDITKNILAESWKSWPNEAAFDRLEEHRGPLRLTLKGTIPSWAGGSLYRTGPGQSRVEDTARGTHFTTHWFDGFAQTHRFDIIPSEDGETQVWYSSRRQADEWIADVKKKGWRSGMTFGQKADPCVGIFAKVMTLFEPKLGNHNVALLANVPGVPKDEKTEVLNGVTGPLGHRVNTSNLFVSTDYTGIRRIDPSTLQPLAETTQYDLHPSLSGPCSCSHAQRDPDSGDLFNFNLAFGRVPTYRIFRVDAASGETEVLATISDLNVPPAYMHSFFLTENHVVICIPASHYAWRGLKTQWEGNIIDSMKPFDKERKCKWLVVDRRHGKGLVATFSTPAAFFFHSINAFEKNIEDEDGTEQTDLFFDLAKYNNMDIIKGFYYDVLMDRDDATKKYWFKNDRYKNCAPTLTRYRFRLPSAPTPDTTFSASAEQVLAIPSPHAGELPTIHPLRNGKPYRYVYSASLRGLTTSVDALVKTDLDTSEAFIWTGPEGHTPGEPVFVPRPGAEAEDDGIVFSLVVDGVNEKAYILCLNGKTMEELGRAEADFAIGQGFHGIHLPAA
What is the function of this protein?
Torulene dioxygenase; part of the pathway that mediates the biosynthesis of neurosporaxanthin, a carboxylic apocarotenoid acting as an essential protective pigments and leading to orange pigmentation (PubMed:17493127).  CarT mediates the cleavage of torulene into beta-apo-4'-carotenal, the aldehyde corresponding to the acidic neurosporaxanthin (PubMed:17493127).  Is also active on other monocyclic synthetic substrates such as beta-apo-8'-carotenal and beta-apo-10'-carotenal to produce beta-apo-14'-carotenal and retinal(beta-apo-15'-carotenal), respectively (PubMed:17493127).  Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities.  Phytoene synthase activity performed by the bifunctional enzyme carAR first produces phytoene from geranyl-geranyl pyrophosphate (GGPP).  The phytoene dehydrogenase carB then introduces 4 desaturations to lead to lycopene which is substrate of the carotene cyclase activity of carAR that leads to the production of gamma-carotene.  CarB then performs a 5th desaturation reaction to yield torulene.  Torulene is the substrate of the dioxidase carT that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase carD mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
What are the official names of this protein?
Torulene dioxygenase, Carotenoid biosynthesis cluster protein T.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
Protein: SWR1_DEBHA
Sequence: MARGGSRRRNTSVISTQKIEPSNESTKAPEGPQKRKPKTEIPNSNGNGVIKKEIKKRKLDNELDESQEHLAQLITDFNLSVNELFQLKEYKTIAYWNPDDFSRASSTSQVPEIFDLFSKEPEYQISWGADSNEQDLSNIPLRLQKKIINEREQKLLEKFPFKEKVLKRSRDLEIELLQNIRQSKKTLEKSHIKPSPPVKPSKTSKGNQKIIKKKQVVKQEEEEAQENHQNEEYESDMDEGTHYKLKAVKYSIPPPIVTHPSHIPSWVPDPNHTESSFNSKDSEIIDYHPDAIQFVSNSKTTYTTPNIQAKIQNFLASYKSAIIDETSSGDFNNTLEEYEKIMTQQEQFIKKLYEKTSIEKRLELNGEKIERRKTVLPHSSNTKQAVDPFRSHGAIIPKTQGVTIHSTHHDYFLSHGMAFSRLHQQMRRQHQLRTKKITQMIEQHFKKKKGEKERLAKEKEQNLKRISKMAVQAVKKRWIQASKVYRFLQLQKEEELKKIKGREHLSQMLEHSTQLLEAQFNKSSRDISEVDTENENETDDHLSSSSDEDSGSPQNARDDSNVNMDENDMQLTVEELRAKYADIDQSIEPSSKTISSDSSNHESDSDDEDIDANKGLVALYGNNAVSVEPVSSLAATEYTDEQKTLIEKFSKEDEGISSESVSDDSLNDSSSSESDDDSEVDESNHKQVDSTKPTGLAALLGNGPTEDEEDSNDDVSADSDGNVSDDENMSTTDEEDEPKTPKSSEDPKMDEKENESDVLEEEVNGSKVRDVPLPPLLRGTLRPYQKQGLNWLASLYNNGTNGILADEMGLGKTIQTISLLAYLAAEHHIWGPHLIVVPTSVMLNWEMEFKKFAPGFKVLTYYGSPQQRAQKRKGWNKPNAFHVCITSYQLVVHDHQSFKRRRWRYMILDEAHNIKNFRSARWRALLNFNTENRLLLTGTPLQNNLMELWSLLYFLMPSSKVNQAMPDGFANLEDFQTWFGRPVDKILEKTSNGTSSDVIDENDKTTQRMDEETRNTVSRLHQVLRPYLLRRLKKDVEKQMPGKYEHIIYCRLSKRQRYLYDDFMSRAQTKETLASGNFLSIINCLMQLRKVCNHPDLFEVRPIVTSLAMPRCVANSFASTDSVVRKYLNDDSFKGQVSLKALNLDITSLDQLNYFTSQTTSKLKSSSELDKQADKLNELISASEYDQPNLDNFLEYYKFIKSNEQVGIRDNLKHASYLNSLRCDRIPLLGESVIKFLQTATQPRQPFTDAYNDIILSIPKRVEKMDDVIEKYSVLTPSVVTLDLKDQLIPLSTQRTIMNEVANKNIDNPFHKSQVKLSIAFPDKSLLQFDCGKLQKLATLLQDLTANGHRALIFTQMTKVLDILEQFLNIHGYRYMRLDGATKIEDRQLLTEKFNRDSKIPVFILSTRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQSRDVHIYRFVSEYTIESNILRKANQKRQLDNVVIQEGEFTTDYFGKFSVKDLVNDAEVADIPDKPLEPAYGNVENVLAQAEDEDDRVAANAAMKEVAIDDEDFDEESKAATNTATPSQTPGPDTAGSGIVDSTVKINNKTDSLEDVDYEDGVSHVDEYMLRFIANGYYWD
What is the function of this protein?
Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
What are the official names of this protein?
Helicase SWR1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYP_DESVV
Sequence: MRWSRCYIPTLKEAPSDAEVVSHKLLVRAGMIRKLTSGIYTFMPMGLRALNKVAAIVREEMNRAGAQEVLMPMVQPADLWQETGRWEFYGKELLRFRDRNDRDYCLGPTHEEVITDLVRGEVRSYRQLPINLYQIQTKFRDEIRPRFGLMRGREFVMKDAYSFDRDQAGCDESYKAMYTAYQRIFSRLGLRFRAVEADSGSIGGSFSHEFMVLADTGEDTLAVCTACEYAANVERAEVTGTPCTRPAAAALAEVPTPGAHTIEEVSAFLGVSADMLVKTLLFVADGEPVAALVRGDRELNEVKLKNLLGADSLELATPEQVEAWTGAPVGFAGPVGLHGVKRVFADTELEGDAGWIVGANKADTHLREVSLTRDAAIEAYADLRMITASDPCPRCGGAVELPKGIEVGHVFKLGLKYSKSMNATFLDENGKEQVMVMGCYGIGVSRVVASCIEQNNDGDGIVFPPPIAPYEVALLLLDPKNEEAAAKAAEIESFLEAEGHDVLLDDRDERPGVKFKDADLIGSPYQLVLGGKGLARGVVEAKNRRSGEKTELPVEGFAEAFRDWRAGVLKGWGL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_LACP7
Sequence: MAMIIDGKRISGEIKDELKAEVSELKSQGKEVTLAVIQVGTDPASTVYVGNKKKACEYCGIRSLAYELPLETTEEELLNLINELNDRDDVTGILVQLPLPDHIEENKVIKTIDPKKDVDGFHPESVGALSIGQAGYLSCTPAGIVQLLKRSGIEIEGKECVVLGRSNIVGKPMALLLLRENGTVTICHSKTKNLSEITKRADILVVAIGKPRFLTKEYVKDGAVVIDVGMHRDENNKLCGDVDYDDVVDKVSAITPVPGGVGPMTIAMLMNNCVYGAKKFQI
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: YR039_YEAS1
Sequence: MSKHKHEWTESVANSGPASILSYCASSILMTVTNKFVVNLDNFNMNFVMLFVQSLVCTVTLCILRIVGVANF
What are the official names of this protein?
Uncharacterized protein SCRG_04509.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PEPB_CITK8
Sequence: MTEAMKITLSTQPADARWGDKATYSINNDGITLHLNGKDDSGLIQRAARKIDGLGIKHVQLTGAGWDVERSWAFWQGYKGPKGSRKVEWPDLDDEKRKELDNRLTIIDWVRDTINAPAEELGPEQLAQRAVDLLCSVACDHVSYRITKGEDLREQNYMGLHTVGRGSDRAPVLLALDYNPTGDKDAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLYLCCADNLISGNAFKLGDIIHYRNGKNVEVMNTDAEGRLVLADGLIDASAQKPELIIDAATLTGAAKTALGNDYHALFSFDDALAGRLLASAAEENEPFWRLPLAEFHRNQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAPVEQWSAGATGLGVRTIANLLTA
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_CHLCV
Sequence: MRNRFGSLFSLTTWGESHGPSIGVVIDGCPAGLLLDPEDFIPAMSRRSPGRPGTSPRKEADIVHILSGVYQGKTTGTPISLQIFNTDVKSATYHQQEDRYRPGHGQLAYEKKYGLVDPLGGGRSSARETACRVAAGVIAAKILAHYDIYCLAFLSKLGKESIETYPKLSKEFAQNIYNSPFLSPLDNDSILQTLTHLQNEQDSLGGVVSFITSPIHESLGEPVFNKVQAVLASGLMSIPAAKGFEIGLGFASTDSYGSEYIDPFIIENENISMGSNNCGGSLGGITVGMPLNGRVAFKPTSSIRKPFLTVTKTGEPSIYATQKEGRHDPCVAIRAVAVVEAMVNLVLADLLLQQRCARL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PROA_AGRRK
Sequence: MLDTVAQSPDIDALMNDIGRKARAASRPLAFASTESKNRALAAMADAILARKDHILAENAKDLKDVEGTDILASFVDRLTLTEKRVAEMAEGIRAIAALPDPVGEVFAAWDRPNGLKIERVRTPLGVIGVIFESRPNVTADAGALCLKAGNAVILRCGSDSRRSSQAILECLVEGLKAAGLPEHAIQLVPVTDRAAVGAMLRGLEGTIDVIVPRGGKSLVARVQSEARVPVFAHLEGLCHVYIDASADLDMAKAIVVNAKMRRTGICGSAETLLVDAKAAQTHLKPLLDGLTEAGCEIRASTEVLRLVPGLKTATEEDWSTEYLDAIISVTIVDGISGAIDHISRYSSNHTEAVIAEDPAVVERFFTEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVHGTGQIRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUXS_HISS2
Sequence: MPLLDSFKVDHTRMNAPAVRVAKTMRTPKGDNITVFDLRFCIPNKEILSPKGIHTLEHLFAGFMRDHLNSEQIEIIDISPMGCRTGFYMSLIGMPNEQQVANAWSASMQDILNVKNQAEIPELNEYQCGTYTEHSLEDAHNIARNILNRGVGINKNEDLLLDDNLLNS
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: ASSY_NITSB
Sequence: MTKKVNKVVLAYSGGLDTSVILKWLQETYNCEVVTFTADIGQGEEVEPAREKALKLGIKPENIFIEDLKEEFVRDYVFPMFRANAIYEGEYLLGTSIARPLIAKRQIEIARQVGADAVAHGATGKGNDQVRFEIAYLSLNPDITVIAPWREWDLNSREKLLKFAEEHRIPIEKHGKKSPYSMDANLLHISYEGGILEDPWAEPEEDMWRWTNSIENAPNEPEYITIDFEKGDPVAINGEPLSPAKLLEALNEYGKKHGIGRIDIVENRFVGMKSRGCYETPGGTILLKAHRAMESITLDREEAHEKDKLMPKYAELIYNGFWFSPEREMMQAAIDKTQENVSGTVRLKLYKGNVFVVGRKSPNSLFAPEFSTFEEDEVYNQKDAQGFIKLNALRFIIEGHVRRKK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DF172_ARATH
Sequence: MAKASSTLVLSIIFLVMFALVEQNMGCTATMGPCEKDKSCSATCRATFGDRANGFCDYSTSTSPGGECTCVYHCPPVVPHESHL
What are the official names of this protein?
Defensin-like protein 172, Low-molecular-weight cysteine-rich protein 60, Protein LCR60.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.