PharMolix/UniProtQA huggingface dataset:
Protein: MOBA_BURCM
Sequence: MSASPSPSITGLLLAGGRATRMDGADKGLQLLDGTPLALHVLRRLSPQVDETLISANRNADRYAELGAPFDARIVADETADFPGPLAGLLAGMRAARAPLVACAPCDTPYLPADVVARLHAALDAQQADIAMAVTVDAQHARSPQPTFALLRTSLADDLAAALAAGERKVRAWYARHKTVEVEFRDERAFYNANSWHELAALARR
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSSA1_YEAS1
Sequence: MSLPATFDLTPEDAQLLLAANTHLGARNVQVHQEPYVFNARPDGVHVINVGKTWEKLVLAARIIAAIPNPEDVVAISSRTFGQRAVLKFAAHTGATPIAGRFTPGSFTNYITRSFKEPRLVIVTDPRSDAQAIKEASYVNIPVIALTDLDSPSEFVDVAIPCNNRGKHSIGLIWYLLAREVLRLRGALVDRTQPWSIMPDLYFYRDPEEVEQQVAEEATTEEAGEEEAKEEVTEEQAEATEWAEENADNVEW
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein S0-A, Nucleic acid-binding protein NAB1A.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: FLIE_TERTT
Sequence: MSNQMDINRLLLEMRALKQQSSAFGGPGAINADRAVQGADQARKLNGPQFGELLEQAVNKVNEVQQASSSMAESYVRGDSSVDVTDVMIASQKAGVAFDAMVQVRNKLVEAYRDVMNMPI
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: Y790_LEVBA
Sequence: MPKTFYEFLMTQRNPESYEPVASFANNAFLDSAFPKQETQFEPLSKYLEENAPYLPSMTIFDDAWQLYLAALA
What are the official names of this protein?
UPF0346 protein LVIS_0790.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: CYB_KAZSE
Sequence: MAFRKSNVYLNLVNSYLIDSPQPSSINYWWNMGSLLGLCLVIQILTGIFMAMHYSSNIELAFSSVEHIMRDVQTGWLLRYTHANGASFFFAVMYMHMAKGLYYGSYRSPRTLVWIIGVIIFVATMAAAFLGYCCVYGQMSHWGATVITNLFSAIPFVGKDIVQWLWGGFAVSNPTIQRFFALHYLVPFIIAALVVMHFMALHVHGSSNPLGITGNLDRLPMHGYFIFKDLITVFVFLIIFSLFVFYSPNTLGHPDNYIPGNPMVTPASIVPEWYLLPFYAILRSIPDKLLGVITMFGAILVLLVLPLTDKSVIRGNTFKVISKLFFFLFVFNFILLGVLGSCHVEVPFVQMGQYATFLYFAYFLIFVPIISYIENLLFYIGNNNS
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SSUB_ECOK1
Sequence: MNTARLNQGTPLLLNAVSKHYAENIVLNQLDLHIPAGQFVAVVGRSGGGKSTLLRLLAGLETPTAGDVLAGTTPLAEIQDDTRMMFQDARLLPWKSVIDNVGLGLKGQWRDAARQALAAVGLENRAGEWPAALSGGQKQRVALARALIHRPGLLLLDEPLGALDALTRLEMQDLIVSLWQEHGFTVLLVTHDVSEAVAMADRVLLIEEGKIGLDLTVDIPRPRRLGSVRLAELEAEVLQRVMQRGHSEQPIRRHG
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SSRP_PSEFS
Sequence: MAKQKKHPTGTIAQNKKARHDYFIEHRFEAGLVLAGWEVKSLRASKLQLVDSYVLLKDGEAWLLGSHITPLTTASTHVIADPVRTRKLLLNARELEKLAAAVQQKGYACICLSWYWSKHLVKCEIALGKGKKEYDKRDTERERDSNRELHRAVRNKGKED
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SIA7F_BOVIN
Sequence: MACPRPLSQCDHTPLPGPPAGHWPLPLSRRRREMKSNKEQRSAVFVILFALITILILYSSSSANEVFHYGSLRGRTRRPVNLRKWSITDGYIPILGNKTLPSRCGQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFHVLRRPQEFVNRTPETVFIFWGPPNKMQKPQGSLVRVIQRAGLVFPNMEAYAISLSRMRQFDDLFRSETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPDYCSLRPHLQRMPYHYYEPKGPDECVTYIQNENSRKGNHHRFITEKRVFSSWAQLYGITFSHPSWT
What is the function of this protein?
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage.  Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal.  ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b.  Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity).  Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity).
What are the official names of this protein?
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, GalNAc alpha-2,6-sialyltransferase VI, ST6GalNAc VI, ST6GalNAcVI, Sialyltransferase 7F, SIAT7-F.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: SSAT_CRYPI
Sequence: MISSFEVRKATIDDYFELRNLICDVTRCTETLSREQAEERFRYNTYHPYCLVDTENGRIVGYAGFYIIPHLGRKNDSRIEHVIISKEYRNRGLGRLLCKQIIEDAKNKFNCGRIDLTVESHIAKKLYSSLEFEKVNTEVMRNSFLDLTPKSD
What is the function of this protein?
Enzyme which catalyzes the acetylation of polyamines.  Displays higher substrate specificity for spermine than for spermidine.  May function to acetylate host-derived polyamines, thus alleviating the necessity for de novo synthesis of these molecules.
What are the official names of this protein?
Diamine acetyltransferase, Spermidine/spermine N(1)-acetyltransferase, CpSSAT.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: RBX1_SCHPO
Sequence: MEDEMQIDKKEVEIEQKPPRFEIKKWNAVALWQWDIVVDNCAICRNHIMDLCIECQANTDSAAAQECTVAWGTCNHAFHFHCISRWLNTRNVCPLDNREWEFQRYGH
What is the function of this protein?
Component of E3 ubiquitin ligase SCF complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.  Seems to recruit the E2 ubiquitination enzyme, like UBC3/CDC34, to the complex and brings it into close proximity to the substrate.  Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation.  H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci.
What are the official names of this protein?
RING-box protein pip1, RING-box protein 1, Pop-interacting protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FIBG_MOUSE
Sequence: MSWSLQPPSFLLCCLLLLFSPTGLAYVATRDNCCILDERFGSFCPTTCGIADFLSSYQTDVDNDLRTLEDILFRAENRTTEAKELIKAIQVYYNPDQPPKPGMIDSATQKSKKMVEEIVKYEALLLTHETSIRYLQEIYNSNNQKITNLKQKVAQLEAQCQEPCKDSVQIHDTTGKDCQEIANKGAKESGLYFIRPLKAKQQFLVYCEIDGSGNGWTVLQKRIDGSLDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQLKDWNGRTSTADYAMFRVGPESDKYRLTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYHQGGTYSKSSTTNGFDDGIIWATWKSRWYSMKETTMKIIPFNRLSIGEGQQHHMGGSKQAGDV
What is the function of this protein?
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity).  Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity).  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity).  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity).  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769).  Maternal fibrinogen is essential for successful pregnancy (By similarity).  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity).  May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity).
What are the official names of this protein?
Fibrinogen gamma chain.
What are the subcellular locations of this protein?
Secreted.
Protein: VSGP_EBORE
Sequence: MGSGYQLLQLPRERFRKTSFLVWVIILFQRAISMPLGIVTNSTLKATEIDQLVCRDKLSSTSQLKSVGLNLEGNGIATDVPSATKRWGFRSGVPPKVVSYEAGEWAENCYNLEIKKSDGSECLPLPPDGVRGFPRCRYVHKVQGTGPCPGDLAFHKNGAFFLYDRLASTVIYRGTTFAEGVIAFLILSEPKKHFWKATPAHEPVNTTDDSTSYYMTLTLSYEMSNFGGEESNTLFKVDNHTYVQLDRPHTPQFLVQLNETLRRNNRLSNSTGRLTWTVDPKIEPDVGEWAFWETKKTFPNNFMEKTCISKFYQPTPTTPQIRARRELSKEKLATTHPPTTPSWFQRIPLQWFQCSLQDGQRKCRPKV
What is the function of this protein?
Viroporin that permeabilizes mammalian cell plasma membranes.  It acts by altering permeation of ionic compounds and small molecules.  This activity may lead to viral enterotoxic activity.
What are the official names of this protein?
Pre-small/secreted glycoprotein, pre-sGP.
What is the protein family that this protein belongs to?
Belongs to the filoviruses glycoprotein family.
What are the subcellular locations of this protein?
[Small/secreted glycoprotein]: Secreted. SUBCELLULAR LOCATION: [Delta-peptide]: Secreted.
Protein: ZFP1_HUMAN
Sequence: MNKSQGSVSFTDVTVDFTQEEWEQLDPSQRILYMDVMLENYSNLLSVEVWKADDQMERDHRNPDEQARQFLILKNQTPIEERGDLFGKALNLNTDFVSLRQVPYKYDLYEKTLKYNSDLLNSNRSYAGKQTDECNEFGKALLYLKQEKTHSGVEYSEYNKSGKALSHKAAIFKHQKIKNLVQPFICTYCDKAFSFKSLLISHKRIHTGEKPYECNVCKKTFSHKANLIKHQRIHTGEKPFECPECGKAFTHQSNLIVHQRAHMEKKPYECSECGKTFAQKFELTTHQRIHTGERPYECNECAKTFFKKSNLIIHQKIHTGEKRYECSECGKSFIQNSQLIIHMRTHTGEKPYECTECGKTFSQRSTLRLHLRIHTGEKPYECSECGKAFSRKSRLSVHQRVHIGEKP
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 1 homolog, Zfp-1, Zinc finger protein 475.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Note=Shows widespread expression throughout the nucleus, but appears to be excluded from nucleoli.
Protein: YMCF_ECOLI
Sequence: MTQHLHFRCPCCHGSQYRTSAFDVTERNPLGAKCIFCKSTMITFDNVALQIRTDHAPLDFTK
What are the official names of this protein?
Protein YmcF.
What is the protein family that this protein belongs to?
Belongs to the YmcF/YnqF peptide family.
Protein: CYB_ANGRO
Sequence: MANLRKTHPLLKIANDALVDLPTPSNISAWWNFGSLLGLCLISQILTGLFLAMHYTSDISTAFSSVAHICRDVNYGWLIRNLHANGASFFFICLYLHIARGLYYGSYLYKETWNIGVVLFLLVMMTAFVGYVLPWGQMSFWGATVITNLLSAVPYVGNSLVQWIWGGFSVDNATLTRFFAFHFLFPFVVAGATMLHLLFLHETGSNNPVGLNSDADKIPFHPYFSYKDLLGFIIMLTALTMLALFYPNLLGDPDNFTPANPMVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLSSILVLMVVPILHTSKQRGLTFRPASQLLFWILVADMLVLTWIGGMPVEHPYIIIGQVASVLYFSLFLVLNPLVGWLENKVMNW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SSB_BPLP2
Sequence: MAIITVTAQANEKNTRTVSTAKGDKKIISVPLFEKEKGSNVKVAYGSAFLPDFIQLGDTVTVSGRVQAKESGEYVNYNFVFPTVEKVFITNDNSSQSQAKQDLFGGSEPIEVNSEDLPF
What is the function of this protein?
Binds ssDNA with nanomolar affinity but no sequence specificity.
What are the official names of this protein?
SSB protein, Gene product 34, Gp34, Single-stranded DNA binding protein.
What is the protein family that this protein belongs to?
Belongs to the skunalikevirus SSB protein family.
Protein: BZAB_MOOTA
Sequence: MSQVLDARAGKITPEMEKVAADEKVDVEFVRAGVAEGTIVIPRNTNRKVLKPCGIGRGLRIKVNALIGTSSDRDDRQMEMRKIAAAEAAGCDSFMDLSTGGDIDEMRRLTLAHARVPVGSVPIYQAAIEAIEKRGSIVAMTPDDMFAAVEKQARDGIDFMAIHSALNFEILERLQASGRVTDIVSRGGAFLTGWMLHNQKENPLYEQFDRLLEILLKYDVTLSLGDAIRPGSTADSLDGAQLQGMIVAGELVRRAREAGVQVMVEGPGHVPLNHVETTMKLQKSLCGGAPYFILGTLATDVAPGYDHITAAIGGALAGTVGADFICYVTPAEHLGLPTEQDVKEGVIAARIAAHAADLARGNRQAWERDLQMARARVALDVEKQISLAIDQEKARSLLDGTGEDGVCAACGTNCAALVAARYFGMN
What is the function of this protein?
Together with BzaA, probably catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.  Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by M. thermoacetica (PubMed:26246619).  Requires BzaA for catalytic activity, as BzaB alone displays no activity (By similarity).
What are the official names of this protein?
5-hydroxybenzimidazole synthase BzaB, 5-OHBza synthase, HBI synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.
Protein: QUEA_ECOLC
Sequence: MRVTDFSFELPESLIAHYPMPERSSCRLLLLDGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGKIEVLVERMLDDKRILAHIRASKAPKPGAELLLGDDESINATMTARHGALFEVEFNDERSVLDILNSIGHMPLPPYIDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLEKLRAKGVEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQDVVDAVLAAKARGNRVIAVGTTSVRSLESAAQAAKNDLIEPFFDDTQIFIYPGFQYKVVDALVTNFHLPESTLIMLVSAFAGYQHTMNAYKAAVEEKYRFFSYGDAMFITYNPQAINERVGE
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYRO_NEUCR
Sequence: MSTDIKFAITGVPTPPSSNGAVPLRRELRDLQQNYPEQFNLYLLGLRDFQGLDEAKLDSYYQVAGIHGMPFKPWAGVPSDTDWSQPGSSGFGGYCTHSSILFITWHRPYLALYEQALYASVQAVAQKFPVEGGLRAKYVAAAKDFRAPYFDWASQPPKGTLAFPESLSSRTIQVVDVDGKTKSINNPLHRFTFHPVNPSPGDFSAAWSRYPSTVRYPNRLTGASRDERIAPILANELASLRNNVSLLLLSYKDFDAFSYNRWDPNTNPGDFGSLEDVHNEIHDRTGGNGHMSSLEVSAFDPLFWLHHVNVDRLWSIWQDLNPNSFMTPRPAPYSTFVAQEGESQSKSTPLEPFWDKSAANFWTSEQVKDSITFGYAYPETQKWKYSSVKEYQAAIRKSVTALYGSNVFANFVENVADRTPALKKPQATGEESKSTVSAAAAHAVELSGAKKVAEKVHNVFQHAEEKAQKPVVPVKDTKAESSTAAGMMIGLSIKRPSKLTASPGPIPESLKYLAPDGKYTDWIVNVRAQKHGLGQSFRVIVFLGEFNPDPETWDDEFNCVGRVSVLGRSAETQCGKCRKDNANGLIVSGTVPLTSALLQDIVGGELQSLKPEDVIPHLRANLKWKVALFNGDEYNLEEVPDLKVSVASTEVTIDEEGLPHYSRQYTVYPEITEGKPCGHGPEDHI
What is the function of this protein?
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
What are the official names of this protein?
Tyrosinase, Monophenol monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
Protein: ANM6_HUMAN
Sequence: MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED
What is the function of this protein?
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520).  Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910).  Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460).  H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460).  Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293).  Repression of TP53 blocks cellular senescence (By similarity).  Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively).  Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869).  Methylates HMGA1 (PubMed:16157300, PubMed:16159886).  Regulates alternative splicing events.  Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1.  Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity).  May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505).  Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity).  Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520).
What are the official names of this protein?
Protein arginine N-methyltransferase 6, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: KDSB_PROMH
Sequence: MFTVIIPGRYASTRLPGKPLADIHGKPMIVRVMEQAKRSGAKRVIVATDNLDVVRAVEQAGGEACMTREDHHSGTERLAEVIEKYQFADDEIIVNVQGDEPLIPPAIITQVAENLANCGAGMATLAVPIVDSKEAFNPNAVKVVMDAKGFALYFSRATIPWERDRFNLSHDEIGEHYLRHIGIYAYRAGFIRRYITWEPSPLESIEMLEQLRVLWYGEKIHVAKALEVPGVGVDTQDDLIAARAAFRALNQEF
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P20D2_XENTR
Sequence: MGPELQGAGGKCSAELSALEACKQRAAERIQEEAESLCELSRDIWSRPELAYQEQQAHETLTRFFSSRAGWLLEPHYKLDTAFRAEWSTPLTDNLSQPLHVGFLCEYDALPSLGHACGHNLIAEVGAAAALGLQGALQCSQPPRPVKITVLGTPAEEDGGGKIDLIEAGAFVDMHVVFMAHPAQEDAAYLPDVAEHDVTVKYYGKASHAAAYPWEGVNALDAAILAYNNLSVLRQQMKPTWRAHGIIKNGGVKPNIIPSYSELEFYLRAPSLKELTKLQEKADACFKAAAAATGCRVELSSSGHDYYNVLQNKTLAKTYVENGKKLGMQFAADNLALNSLSGSTDFGNVSFVVPGIHPYFYIGSDALNHTEEYTEAAGSKEAQFYALRTAKALAMTALDVLFNPDLLANVCEDFKLIKLIEEGNMHVTEKSRESSGGAGCASR
What are the official names of this protein?
Peptidase M20 domain-containing protein 2, Aminoacylase-1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
Protein: RSSA_ASPCL
Sequence: MAPSQLPPMFNPTPQDIEMLLAAQCHLGSKNLQVHMEPYLWKTRPDGVNVINIGKTWEKILLAARIIAAIDNPADICVISARPYGQRAVLKFASHTGATAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDTDSPTDFVDVAIPTNNKGRHAIGLVWWLLAREVLRLRGTLANRETEWDVVVDLYFYRDPEAEENKEIAEETKVPGAEEIGAGAVESGFAGENWDTQAPGAGVPGSAFAAASAAAATSWEADGGDWAASSAPPAGESWAETQPTEAKW
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein S0.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURNU_STAHJ
Sequence: MSEKFVKYPHHLKYESQDLKHVKLGFTTREGGYSLYPESSFNMARYVDDNPENITKHQEMLADAIGFVRAQWVFPIQTHENRVMEISQSHRGTNIDTLTDDMYGIDGIYTYEPDTLLTMCYADCVPVYFYSEKHHYVGLAHAGWRGTYGQIVSEMLKQIDFDYNDLKIVIGPSTSTTYEINDDIKAKFETLPINVKDYIETRGENRHGIDLKRANALLLNHYGVPFDNIYITDYATSEDLSLFFSYRVEKGQTGRMLAFIGQK
What is the function of this protein?
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine.  Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate.  Also has adenosine deaminase activity.
What are the official names of this protein?
Purine nucleoside phosphorylase SH1728, Adenosine deaminase SH1728, S-methyl-5'-thioadenosine phosphorylase SH1728.
What is the protein family that this protein belongs to?
Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.