PharMolix/UniProtQA huggingface dataset:
Protein: PCCA_MOUSE
Sequence: MAGQWVRTVALLAARRHWRRSSQQQLLGTLKHAPVYSYQCLVVSRSLSSVEYEPKEKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFAKRLAAEDVTFIGPDTHAIQAMGDKIESKLLAKRAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDPETRQAMGEQAVALAKAVKYSSAGTVEFLVDSQKNFYFLEMNTRLQVEHPVTECITGLDLVQEMILVAKGYPLRHKQEDIPISGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPIHLPGVRVDSGIQPGSDISIYYDPMISKLVTYGSDRAEALKRMEDALDNYVIRGVTHNIPLLREVIINTRFVKGDISTKFLSDVYPDGFKGHTLTLSERNQLLAIASSVFVASQLRAQRFQEHSRVPVIRPDVAKWELSVKLHDEDHTVVASNNGPAFTVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTVQCLSREAGGNMSIQFLGTVYKVHILTKLAAELNKFMLEKVPKDTSSTLCSPMPGVVVAVSVKPGDMVAEGQEICVIEAMKMQNSMTAGKMGKVKLVHCKAGDTVGEGDLLVELE
What is the function of this protein?
This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites.  Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity).  Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity).  Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity).  Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).
What are the official names of this protein?
Propionyl-CoA carboxylase alpha chain, mitochondrial, PCCase subunit alpha, Propanoyl-CoA:carbon dioxide ligase subunit alpha.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: NTM1B_DANRE
Sequence: MEFSGTHQAFRNRWAKTDDEMCKHSMSFHLHKTLRKEFFASYLYLLEQIPLVKLYALTCEYIKGEKQFYYRAQNFYKDVPPSEEGMMGDFVEISDIDLEGSRQFLKKFVGPGKAGTKCALDCGCGIGRVSKGVLFPVFESMEMLDMMEEFILHAHECYLGDYADRVESYYLYNLQEFIPPRKKYDVIWMQWVACHLTDKDLMEFLMRAKESLRPNGVIIIKDNMARQGCKLDPIDSSIIRHLDIMNGIIQRAGLNILDVEKQEGFPEAIVPVWMIAMR
What is the function of this protein?
Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved.  Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif.  Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro).  May activate NTMT1 by priming its substrates for trimethylation.
What are the official names of this protein?
N-terminal Xaa-Pro-Lys N-methyltransferase 2, Alpha N-terminal protein methyltransferase 1B, Methyltransferase-like protein 11B, X-Pro-Lys N-terminal protein methyltransferase 1B, NTM1B.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. NTM1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MPI_EMENI
Sequence: MQVPLLRLQCGVNSYDWGRVGPESAAAKYAAATAPSDFTIEADKPYAELWMGTHPSLPSKDVETQRTLLDMVQDNLALMSPEVSERYGGKLPFLFKVLSIRKALSIQAHPNKKLAEALHARDPRNYPDDNHKPEMTIAITPFEGLCGFRPLAEIVHFLKAVAPLRYLIGVQTATDFENAVRGFENTEDPEQTKKNKVALRTLFTSLMQSASENIEQAARELVAAAQSSPETFASLVNAPDTNPTNAAELASIIIRLNEQFPNDIGLFVFFFLNFVRLEPGEAMFLKADDIHAYISGDIIECMASSDNVVRAGFTPKFKDVDTLTEMLTYSYAPIDEQKLQPTDYPYTVLNAAAYSSASDSLLYDPPIEEFSVVKTSLRRTGAKATFDPLTGPSILICTGGTGKISVGHKTEEVKEGYVFFVGANAECIIENTGTGSDEENVFTTFKAFCDLTGKEDMANGH
What is the function of this protein?
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
What are the official names of this protein?
Mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI.
What is the protein family that this protein belongs to?
Belongs to the mannose-6-phosphate isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP1_ARATH
Sequence: MATQFSASVSLQTSCLATTRISFQKPALISNHGKTNLSFNLRRSIPSRRLSVSCAAKQETIEKVSAIVKKQLSLTPDKKVVAETKFADLGADSLDTVEIVMGLEEEFNIQMAEEKAQKIATVEQAAELIEELINEKK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein 1, chloroplastic, ACP-1.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DEOB_SHIFL
Sequence: MKRAFIMVLDSFGIGATEDAERFGDVGADTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLAKAHEGSTGFIPAGMDGNAEVIGAYAWAHEMSSGKDTPSGHWEIAGVPVLFEWGYFSDHENSFPQELLDKLVERANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTNGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKHGQVVSVGKIADIYANCGITKKVKATGLDALFDATIKEMKEAGDNTIVFTNFVDFDSSWGHRRDVAGYAAGLELFDRRLPELMSLLRDDDILILTADHGCDPTWTGTDHTREHIPVLVYGPKVKPGSLGHRETFADIGQTLAKYFGTSDMEYGKAMF
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIG_ESCF3
Sequence: MNAEKSPVTPNVDHEEIAKFEAVASRWWDLEGEFKPLHRINPLRLGYIAERAGGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGIQVNYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYILRMVPKGTHDVKKFIKPAELLGWVDQTSLKERHMTGLHYNPITNTFKLGPGVDVNYMLHTQNK
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-octaprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone-8 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: RL6_BACVZ
Sequence: MSRVGKKLLEIPSGVTVTLNEGNTVAVKGPKGELTRTFHPDMEIKIEDNVLTVTRPSDHKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRAAKSGNKLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKGKGIRYEGEVVRRKEGKSAK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: MENG_CORGB
Sequence: MAKADLDKDPFDVASMFDDVGKNYDLTNTVLSFGQDRVWRKRTRQRLDLKPGEKVLDLAAGTAVSTVELAKSGAFCVACDFSQGMLAAGKDRDVSKVVGDGMQLPFADNSFDAVTISYGLRNIHDFRAGLKEMARVTKPGGRLTVAEFSTPVIPVFGTVYKEYLMRLLPQVARAVSSNPEAYIYLADSIRAWPSQAELAREINQNGWSDCGWQNLTFGIVALHSAIKPEN
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: COR1C_HUMAN
Sequence: MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA
What is the function of this protein?
Involved in myogenic differentiation.
What are the official names of this protein?
Coronin-1C, Coronin-3, hCRNN4.
What is the protein family that this protein belongs to?
Belongs to the WD repeat coronin family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Endosome membrane. Note=All isoforms colocalize with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:10828594, PubMed:19651142, PubMed:25074804). Colocalizes with F-actin at the leading edge of lamellipodia. Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:10828594, PubMed:19651142, PubMed:25074804). Localizes to endosome membrane tubules/buds (PubMed:30220460). SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane, sarcolemma. Cytoplasm, myofibril, sarcomere. Synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates. Colocalizes with the actin cytoskeleton in the cytosol, and especially in the cell cortex.
Protein: YDFH_ECO57
Sequence: MTVETQLNPTQPVNQQIYRILRRDIVHCLIAPGTPLSEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISMAQVRNGSFIRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERKQLDDFFELDDNFHQLLTQIADCQLAWDTIENLKATVDRVRYMSFDHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQHLQEISESVRQIRQENSDWFSEE
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YdfH.
Protein: RUBY_CLOPE
Sequence: MKSLKGTKTAENLMKSFAGECQARTRYTYFSSTARKEGYVQISNIFLETAENEKEHAKRFYKFLKDDLQGEAVEINAAYPVELPTDTLTNLKFAAEGEHDELSNLYPSFADVADEEGFPEVAAAFRMIAKAETAHYNRFMKLAKNIEEGKVFKKDEVVLWKCGNCGFIWEGAEAPLKCPACLHPQAYFEVFKETY
What is the function of this protein?
May provide oxidative stress protection via catalytic reduction of intracellular hydrogen peroxide.
What are the official names of this protein?
Rubrerythrin, Rr.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNC_PSEPF
Sequence: MTLRLKQAFLHHTNGVEALRGVDLQIEAGEQVAIIGPSGAGKSSLLNMLATAIRPSSGDIEVLGERAWHLSARQRQRLRARIGLVHQAPPLPPRQRVVTAVLAGKLGQWSLGKSLINLLHPLDVPGARAALAKLDLADKLFSQCQQLSGGQLQRVGIARVLYQAPEVLLADEPVSAMDPVLAGHTLSILSRHAREHNVTLVASLHAVELALAHFPRIVGLREGRILFDCPSAQVSRDMLDTLYANEQLQSPAPAVTPLIVQIPRC
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ARGD1_BORPA
Sequence: MSSALANIYARLPVSFTHGRGVWLWDTGERRYLDALAGIGVSCLGHGHPGLVAAISEQAARLIHTSNIYEVPQQAALARRLAELSGMSEVLFSNSGSEANEAAIKLARYYGYKQGNTHAHIITMDSSWHGRTLATLAATGSDKARQGFGPMPSGFIQVPYNDLPAIRAAGEAEPRVTAVLLEVLQGEGGIRPSDMAFLRGVRQLCTERGWLLMIDEVQSGIGRTGKWFAHQWADIRPDVMTLAKGLAGGVPIGAMLAAGPAAGVFAPGSHGTTFGGGPLACAAGLAVIDAIEQEGLLANAHEVGAHLHAALASELAGVPGIIEVRGHGLMLGIELDRPCGILATRAMEAGLLINVTRERVVRLLPPLILSGEEADQIVRILVPLIKQFLAQQQ
What are the official names of this protein?
Acetylornithine aminotransferase 1, ACOAT 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUFT_STAA3
Sequence: MVIDPELGIDIVNLGLVYKVNVDDEGVCTVDMTLTSMGCPMGPQIIDQVKTVLAEIPEIQDTEVNIVWSPPWTKDMMSRYAKIALGVS
What is the function of this protein?
Involved in the maturation of iron-sulfur (Fe-S) proteins (PubMed:27671355, PubMed:27517714).  May function as a Fe-S cluster carrier (PubMed:27671355).  Is required for S. aureus growth under conditions that impose a high demand for lipoic acid, likely via a role in the maturation of the lipoate synthase LipA (PubMed:27671355).  Is non-essential for growth in conditions that impose a low demand for lipoic acid or Fe-S clusters, such as fermentative growth (PubMed:27671355, PubMed:27517714).  Seems also to be involved in the maturation of AcnA, LeuCD and IlvD proteins, that utilize Fe-S cluster cofactors, and its role increases under conditions of high-demand for Fe-S clusters (respiratory growth) (PubMed:27517714).  Is not involved in the repair of Fe-S clusters damaged by reactive oxygen species or in the physical protection of Fe-S clusters from oxidants (PubMed:27517714).  Displays synergy with the Fe-S cluster carrier Nfu (PubMed:27517714).
What are the official names of this protein?
Fe-S protein maturation auxiliary factor SufT, Fe-S protein maturation accessory factor SufT, Iron-sulfur cluster assembly factor SufT.
What is the protein family that this protein belongs to?
Belongs to the MIP18 family.
Protein: SC242_CANGA
Sequence: MSHHKKRVYPQAQFQYGAGVPPAGIPVSDASIIPPQVQSPQVGATDNMIPPYNQTPTMNQMEQAPQAQMFTPAQQQLNQQINSVTTNMGAMNIGTPMMEQMPQQMTPQPQMYGQSQGLMGHSNKPMNQLYPVDLLTELPPPIHDLMLPPPPLMVSPDKMLVPSETANASSDYLRCTLNAMPKNGSLLKKSKLPLALVIRPYQHLHDEVNPPPLNEDGLVVRCRRCRSYMNPFVTFIEQGRRWRCNFCRLANDVPMQLDQSFEGAPANRYERNEIKHSVMEYLAPKEYTVRQPPPSTYIFVLDVSQNAVKNGLLATTARSILDTLEFLPNHDNRTRVSILAVDNSLHYFSIPLDEESDQIRMMDISDIDEPFLPKPHSMIVPLNECRNNLEKLLTQLPEIFQFNIMSKFALGPALKAAQNMISNLGGKIVVVSATLPNIGIGKLQRRNESGVANTPKESTQLLSCQDAFYKNFTITCSKSQVSVDLFLASEDYMDVASLSNLGRFTGGQTHFYPGFTAANIADVTKFTKEFSKFLSMDLSTETVMRARGSTGIRMSAFYGHFFNRSSDLCAFSTMPRDQSYVFEMSIDENIGTEYCYVQIAVLLSLNTSQRRIRIITVAIPTTESLSEVYASADQLAIADFFTKKAVEKAMNSSLQDARDLLNKSLQDILATYKKEIVVSNTAGGAPLRFCANLRMLPLLVHALSKHTAFRAGIVPSDHRAAALNNLESMPLKYLVKSAYARVYSLHDMVDEAGYPDENGEIVLPEPINASASLFERYGLYLIDNSSELFLWVGGDAVPELVNDVFGLQDIFQIPNGKHELAIVEGSEFNERVRNIIQKVREHDDVITYQTLYIVRGPSVSEPVGHAAGRELQPLRMWATSNLVEDKVLGTESYREFLQTLKNKLNK
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC24-2.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GLYA2_VIBVU
Sequence: MNSHYQNHSLENFFSTNLSATDDAVFAGIQAEFTRQNEQIELIASENIVSKAVMQAQGTCLTNKYAEGYPGRRYYGGCEHVDTVEAIAIERAKKLFNCEYANVQPHSGAQANGAVKLALLQPGDTIMGMSLDAGGHLTHGARPALSGKWFNAVQYGVDKETLEINYDDVRALAVEHKPKMIIAGGSAIPRVIDFAKFREIADEVGAILMVDMAHIAGLIATGAHPSPLPHAHVVTTTTHKTLRGPRGGMILTNHEEIIKKINSAVFPGLQGGPLMHVIAAKAVAFGEALGPEFKTYIDSVIDNAKVLAEVLQTRGCDIVTGGTDTHLMLVDLRPKGLKGNKAEEALERAGITCNKNGIPFDTEKPMITSGVRLGTPAGTSRGFGAEEFKLIGHWIGDVLDGLVENPEGNAEVEQRVRKEVKALCSRFPLYQ
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 2, SHMT 2, Serine methylase 2.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIKD_BRUA2
Sequence: MTRKTLAIEGLTATTVIDGQQRVLVDNLSLGVQRGRILALVGASGSGKSMTCSAALGVLPPGVTASRGRVTIDGVPYAANALRGRHVATIMQNPRSAFNPVRTMRDHAIETLQALGKLSSNPQDQIVHCMRAAGLEDVKTILSLHPFEMSGGMLQRMMIALALLSEAPFLFADEPTTDLDLVVQLRVLELLEKLVEERDLGILLVTHDMGVVARLAHDVAVLDHGRLIEQAPVMDIFQTPGHEVTRMLVSAHLSLYGMELNA
What is the function of this protein?
Part of the ABC transporter complex NikABCDE involved in nickel import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Nickel import ATP-binding protein NikD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VP15_NPVOP
Sequence: MRTRSVDQDSKLCFFKALGLRPQEPLRRVACSVANKCAAKQYKRFKGVADIKRELGRFNLPPAQFNEALYLCRRHNAAWCTTDNWDRCGSVNERHVYEVDFDAQTKAVTERFYVCVQCFV
What are the official names of this protein?
Putative 15 kDa capsid protein.
What are the subcellular locations of this protein?
Virion.
Protein: PYRE_COLGR
Sequence: MASQLPPYKQDFLKAAIAGVLKFGSFELKSKRISPYFFNAGDFYRADLLRAISLAYAHTVIEAREATGLDFDVVFGPAYKGIPLATSTTDKLAELDPARYGTTCYSFDRKEAKDHGEGGNIVGAPLKGQKVLIVDDVITAGTAKREAIAKIRKEGGEVVGIVVALDRMEKLPAADGDDSKPGPSALGEIKKEYGIPIFSILTLDDIIEGAKSFASAEDIKRTEEYRAKYKATD
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: HHIP_HUMAN
Sequence: MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNPPKRLKRRDRRMMSQLELLSGGEMLCGGFYPRLSCCLRSDSPGLGRLENKIFSVTNNTECGKLLEEIKCALCSPHSQSLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRGHIPGFLQTTADEFCFYYARKDGGLCFPDFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCFCIQEVVSGLRQPVGALHSGDGSQRLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGKDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTSGSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDRNIRRVTRAGILDQIIDMTSYLLDLTSYIV
What is the function of this protein?
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
What are the official names of this protein?
Hedgehog-interacting protein, HHIP, HIP.
What is the protein family that this protein belongs to?
Belongs to the HHIP family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Secreted. Note=The last 22 C- terminal amino acids may participate in cell membrane attachment. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: HSP1_RAT
Sequence: MARYRCCRSKSRSRCRRRRRRCRRRRRRCCRRRRRRCCRRRRSYTFRCKRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1, Cysteine-rich protamine.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: HIS1_XANCP
Sequence: MSASTAAPARDRLRIAIQKNGRLAEPARSLLAACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIADGVCDLGIVGQNELDEQASARRRAGLPAAYHAVRGVGFGQCRLMLAVPEEWGWQGVAQLAGKRIATSYPAILADWLERQGIDASVVELSGSVEIAPRLGTADLICDLVSSGATLAANQLKPVELVMESEAVLAGAVREPADARAALLAMLLRRMDGVLKLRDSKLLMFRAEQGNVDALRRLLPDADPLVQLPDDGNGALRLQTMCHGAVTWQRLEELERAGAQGLMVLTVERSLA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PT117_DANRE
Sequence: MSTASKVVLGLSIVLTISTVAGVHIKQNWDRQRLREGVVRDLERLERKRENLRALEEQIQLTRELVTERNRRQAEASETH
What are the official names of this protein?
Protein PET117 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PET117 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PCP_STRP2
Sequence: MKILVTGFNPFGGEKINPALEAVKLLPSEINGAEVRWVEIPTVFYKSSEVLEAEILRYQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPIRIDGASAYFSSLPIKAMVQAIKKQGLPAVVSNSAGTFVCNHLMYQALYLVDKKFPNMRAGFMHIPYMMEQVVNKPNTAGMSLCDIVRGIEVAIEAIVDYKDKDLQLVGGETH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMEA_ARCFU
Sequence: MMSRRKFLLLTGAAAAGAILTPQISAKTQFIESPEEVREKRRWAMAVDVERCTQCMEELIAKTGDEKIKPPCVVACDKENNVPEFEEERFDPQWMRIAKLKLDKPEVNPKEYYIPLLCNHCEHPPCVQVCLTKASFKRPDGIVEIDMHRCIGCRYCMIACPYGARCFNFIDPREGLKEVNPNVQMRTEGVVEKCTFCVHRIDEAVKKGEEPIPACVEACHKYGKGALVFGNIKDPNSEISKILRENIVVQLRANLGTDPHVFYAKLGGE
What is the function of this protein?
Has menaquinol-oxidizing activity.  HmeA, HmeB and HmeE subunits may together catalyze electron transfer from menaquinol to cytochrome c.
What are the official names of this protein?
Hdr-like menaquinol oxidoreductase iron-sulfur subunit 1, Hme subunit A.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Extracellular side.
Protein: MREC_HAEIN
Sequence: MKPIFGKAPPLGIRLLIAIFASIALILADGRNSSITKARSAMETAIGGLYYLANSPRSILDGISENLVDTNKLQIENKVLRQQLLEKNADLLLLDQLKVENQRLRLLLNSPLRTDEYKKIAEVLTAETDIYRQQIVINQGKKDGAYVGQPVIDEKGVIGQIISVGENTSRVLLLTDVTHSIPVQVLRNDVRVIASGTGHTDELSLDNVPRSVDIEKGDLLVTSGLGGRFLEGYPVAVVQSVSRDSSNYFAIVKAKPLALLERLRYVLLLWPSNLDISKVKSISPEEVRNLVQKRLESQANEANYRVKKTPLTEKDFLENEEKTIIEPDIPTDFLQNEEDLPIEQQEERIED
What is the function of this protein?
Involved in formation and maintenance of cell shape.
What are the official names of this protein?
Cell shape-determining protein MreC, Cell shape protein MreC, Rod shape-determining protein MreC.
What is the protein family that this protein belongs to?
Belongs to the MreC family.
Protein: SEPF_PROM1
Sequence: MSLISRLRAVVAGDDFLDSDFDELEYDSSDDFENFNRGNKEGSTEMATISQANPFDGRSGFPPSNVIGMPGISTNDSEVSLMEPRSFDEMPRVIQALRERKTVILNLTMMEPDQAQRAVDFVAGGTFAIDGHQERVGESIFLFAPSCVTVTNSFQEEASPSNMSNKGNDLISKETSPAPEPAWGETVATAL
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.