PharMolix/UniProtQA huggingface dataset:
Protein: ECFA2_LACDB
Sequence: MAIKFENVSYVYSPGSPLEAIGLDQLNFSLEEGKFIALVGHTGSGKSTLMQHFNALLKPTSGKIEIAGYTITPETGNKGLKDLRRKVSLAFQFSEAQLFENTVLKDVEYGPRNFGFSEDEAREAALKWLKKVGLKDDLIEHSPFDLSGGQMRRVALAGVLAYEPEIICLDEPAAGLDPMGRLEMMQLFKDYQAAGHTVILVTHNMDDVADYADDVLALEHGRLIKHASPKEVFKDSEWLQKHHLAEPRSARFAAKLEAAGLKLPGQPLTMPELADAIKQSLKGGEHE
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL5_LISW6
Sequence: MNRLKDQYLKEIVPALMSKFNYDSVMEVPKIDKIVINTGVGDATANAKVLDSAVEELALITGQKPVITKAKNSIAGFRLREGMPIGAKVTLRGERMYDFLDKLVTVSLPRVRDFRGVSKKAFDGRGNYTLGVREQLIFPEIDYDQVSKVRGMDVVIVTTAKSDEESHELLTQLGMPFQK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: FLIE_BRUME
Sequence: MYDSIMSVSARNALSRLSETVAEKGVGSASAPQAVPAAPGASFGEVLSQMTGSVSQKLQAAEATSIQGIKGDAPVRDVVSSVMEAEQSLQTAIAIRDKIVQAYLEISRMPI
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: 3NO2I_NAJAT
Sequence: MKTLPLTLVVVTIVCLDLGYTLTCLNCPEMFCGKFQICRNGEKICFKKLHQRRPFSLRYIRGCAATCPGTKPRDMVECCSTDRCNR
What is the function of this protein?
Binds with low affinity to muscular (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and very low affinity to neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR).
What are the official names of this protein?
Probable weak neurotoxin NNAM2I.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Ancestral subfamily. Orphan group II sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: METE_STAAT
Sequence: MTTIKTSNLGFPRLGRKREWKKAIESYWAKKISKEELDQTLTDLHKENLLLQKYYHLDSIPVGDFSLYDHILDTSLLFNIIPERFQGRTIDDDLLFDIARGNKDHVASALIKWFNTNYHYIVPEWDNVEPKVSRNVLLDRFKYAQSLNVNAHPVIVGPITFVKLSKGGHQTFEEKVKTLLPLYKEVFESLIDAGAEYIQVDEPILVTDDSESYENITREAYDYFEKAGVAKKLVIQTYFERAHLKFLSSLPVGGIGLDFVHDNGYNLKQIEAGDFDKSKTLYAGIIDGRNVWASDIEAKKVLIDKLLAHTNELVIQPSSSLLHVPVSLDDETLDTSVGEGLSFATEKLDELDALRRLFNQNDSVKYDKLKARYERFQNQSFKNLDYDFESVRTSRQSPFAQRIEQQQKRLNLPDLPTTTIGSFPQSREVRKYRADWKNKRITDEAYETFLKNEIARWIKIQEDIGLDVLVHGEFERNDMVEFFGEKLQGFLVTKFGWVQSYGSRAVKPPIIYGDVKWTAPLTVDETVYAQSLTDKPVKGMLTGPVTILNWSFERVDLPRKVVQDQIALAINEEVLALEAAGIKVIQVDEPALREGLPLRSEYHEQYLKDAVLSFKLATSSVRDETQIHTHMCYSQFGQIIHAIHDLDADVISIETSRSHGDLIKDFEDINYDLGIGLGVYDIHSPRIPTKEEITTAINRSLQQIDRSLFWVNPDCGLKTRKEEEVKDALTVLVNAVKAKRQE
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: MINE_ACIET
Sequence: MSLLSFLLGEKKKTASVAKERLQIILAHERSGRSAGQPDYLPALQRELVAVISKYVKINADDLKVHFERQDDLEVLEVKIELPEATAK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: HSP7C_CHICK
Sequence: MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDSVVQSDMKHWPFTVVNDAGRPKVQVEYKGETKSFYPEEISSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQGTKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNLLIFDLGGGTFDVSILTIENGIFEVKSTAGDTHLGGEDFDNRLVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEKLNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLDSYAFNMKATVEDEKLPGKILDEDHQNILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
What is the function of this protein?
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes (By similarity).  Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (By similarity).  This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (By similarity).  The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state (By similarity).  In the ATP-bound form, it has a low affinity for substrate proteins (By similarity).  However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins (By similarity).  HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (By similarity).  Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (By similarity).  KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (By similarity).  May play a role in regulating apoptosis during embryonic development (PubMed:9707581).
What are the official names of this protein?
Heat shock cognate 71 kDa protein, Heat shock 70 kDa protein 8.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
Protein: TIG_SOLM1
Sequence: MEYTVNQLSPVKTQVTVSVPAEEANAALASAVAMFRSRTDLKGFRKGKVPSSVVEQRFKKEIVSEATTDLINVHINEIMGELKLSPLSGLDVSEAALTKGEPLEYTFSFEHAPAFDLPEYKGQAVEEEDVVVSEADIESVIERVRKNLAEVKPLSDNRPAKDGEIVSVTFEAFEDGKAIPGVRAENFELTLGEGQALPAFEELVKTIASGNEGEGDVTFPADFINTELAGRTVTMKVAVHVIKERTLPPVDDELAKKAGNFENLDKMREAITMSYKKSREDLHRSSAQKKLLDSLLATLDFPLPPAVVEQQLGQMVEEFVGQLERRGKSLESTGKTLADIQGEMRPRAEELVKTQIFLSAVALKEELTVTPQEMDAFFYRLSTQAGQDVIMLKRYYEDNGLMIMVRDKLLCDKAADLIYANALVTKVAPVEKPAGEEAQD
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PSBA_VIGUN
Sequence: MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGSSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAMEAPSVNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RISB_TERTT
Sequence: MTIKIIEGDFKSATGKYALLVSRWNSFVVEHLKEGALDTLRRHGVSDDDIEIVYAPGAFEFPLAAQKLAASGDYDAIVALGAVIRGGTPHFDYVAGECTKGLAQVSLATGIPVAFGVLTVDSIEQAIERSGTKAGNKGSEAAETALEMVSLLGKL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RRAGA_BOVIN
Sequence: MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR
What is the function of this protein?
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.  Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form.  In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB.  Involved in the RCC1/Ran-GTPase pathway.  May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.
What are the official names of this protein?
Ras-related GTP-binding protein A, Rag A, RagA.
What is the protein family that this protein belongs to?
Belongs to the GTR/RAG GTP-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Lysosome.
Protein: CH10_NEIMB
Sequence: MTIRPLHDRVVVKRLEAEEKTASGIVLPGAAAEKPDMGEVIAVGAGKIGKDGSRRPLDVKVGDKIIFGKYSGQTVKADGEELLVMREEDIFGIVEK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_METS4
Sequence: MAVPKRKTSPSRRGMRRSADALKAPTYVEDKDSGELRRPHHIDLKTGMYRGRQVLKVKTEA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RNH2_BORBR
Sequence: MEQPDLFGTLAPLPAIIAGVDEAGRGPLAGAVYAAAVILDPDRPVDGLADSKVLKAEQREALAVQIRAQALAWFVASASVQEIDSLNILRATMLAMQRAVAGLAMAPELAMVDGNQAPKLRCAVQTVIKGDALVPAISAASILAKTARDADLLRLHALYPQYGFDQHKGYGTPQHLSLLREHGPCPEHRRSFAPIKAYGAP
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYS4_CRYNB
Sequence: MVAIPRLARLSVPAWALSARGRFYATVSTPQTLVEKIVQKYAVGLSEGVKVRAGDYVMIKPEHVMTHDNTGPVISKFLSLSCSKLDNPRQPVFALDHDVQNQSETNQKKYKKIQAFAKEHGVDFYPAGRGIGHQIIVEEGYAWPGKMVVASDSHSNHYGGVGCLGTAIVRTDAAGIWATGKFWWQIPRIVSVSLDGRLSPGVTGKDVIVALAGLFNKDEVLNAAIEFTGSGVEHLSIDERLTIANMTTEWGAVAGVFPVDDKLKEWYQGILRKAELRKFISPTVPSTVGAKVHPRLNAARLDDAMTNRVVADPGAHYAARLSLDLSTLVPHVSGPNSVKVATALPKLLDPPIPINKAYLVSCTNSRASDIASAAQVLRGKKVAPGVEFYIAAASSRVQEDAEAAGDWQTLIDAGAKTLPAGCGPCIGLGVGLLEKGEVGISATNRNYKGRMGSPDAIAYLASPAVVAASAAKGVICGPESMDLSQLPQYEQPKFSIIKEGAAGEEKPVEVDEASLEPLLEGFPAYFEGPLLFAPQDNLTTDGMYPGKYTYQDDITPERQAEVVMENYDPTFAATARELRTALPTASSPSTLPGAILLSGYNFGTGSSREQAATAIKNAGIPLVICGSFGDIFKRNSINNGLILIESPSLIKDMTERFAKDGVRNKGGKDGKLTVVPEGWRIKVDSQRGLVTVNMGEEEEKTYPAAKVGRSVQELWVNGGLEGFIRASL
What is the function of this protein?
Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
What are the official names of this protein?
Homoaconitase, mitochondrial, Homoaconitate hydratase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MDGA1_MOUSE
Sequence: MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIRESDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTVSDVRGNFYQEKTVFLRCTVSSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFQLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLHWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSLKNATFQITPDMIKESENIQLGQDLKLSCHVDAVPQEKVNYQWFKNGKPARTSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGSPVPDLSIEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLALEETPDGKLRLESVSRDMSGTYRCQTARYNGFNVRPREAQVQLTVHFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVLPAAAVETPDHAELRLDALTRDSSGNYECSVSNDVGSATCLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAMVKAIPVRRVEKGQLLEYILTDLRVPHSYEIRLTPYTTFGAGDMASRIIHYTEPINLPSLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGTLDTHAWSLSGNKGNVWQQAHVPINPSGPFQIIFEGVRGSGYLGDIAIDDVTLKKGECPRRQMDPNKVVVMPGSGAPRLSSLQLWGSMAIFLLALQR
What is the function of this protein?
Required for radial migration of cortical neurons in the superficial layer of the neocortex.  Plays a role in the formation or maintenance of inhibitory synapses.  May function by inhibiting the activity of NLGN2.
What are the official names of this protein?
MAM domain-containing glycosylphosphatidylinositol anchor protein 1.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Note=Associated with lipid rafts.
Protein: MRAY_GLUDA
Sequence: MLYDLIQHHGSAHVTVLNLFRYITFRAGAACLTALAISLLLGNPLIAQLRRIQREGQPIRALGPERHILEKAGTPTMGGVLILAALFGSTLLWADLTDGYVWAVLLTTLSFGAVGFADDYLKLSRRNTAGVSKRMRLGCEFAASLVGGYWMQSLMPADLANHLAFPFLKEWLLPLGFAFPLFAMITITGFGNAVNFTDGLDGLAIVPVIIAALVFGLISYLVGNHVFADYLQLHAVPGTGELCVFCSALVGAGLGFLWFNAPPAAVFMGDTGSLSLGGALGAIAVAVKHELVLCIVGGLFVVETLSVIIQVFWFRRTGRRVFLMAPLHHHFEKKGWQEPKIVIRFWIVSIVLGLCGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF1_LACAC
Sequence: MAKDDVIEVEGKVVDTLPNAMFKVELENGATILAHVSGKIRMHYIRILPGDRVTVELSPYDLTKGRITYRFIK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NS3B_FIPV
Sequence: MIGGLFLNTLSFVIVINHVIVNNTANVHTTQHENVIVQQH
What are the official names of this protein?
Putative truncated non-structural protein 3b, ns3b, Accessory protein 3b.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses NS3b protein family.
Protein: HRCA_CORA7
Sequence: MSSSTDARRQEVLRAIVADYIASQSPVGSKALLERYQLGVSSATIRNDMAVLEAEGLIAQEHASSGRVPTQKGYRQFVDTLHDVKPLSKAERRAMLTFLEGGVDLEDVLRRSVQLLAQVTKQAAVVQLPNLKVSRVKHCEVVALSPVRLLLVLITDNGRVDQRNVELDDVIDPEQTHRLRDILNTALEGKTLTEASVELAALVDDSPADIRPHLLKAATTLIETLVEQPSDRLIMAGTSNLTRVALTEGLPSIIEALEEQVVVLKLLARVPDLGNVSVSIGEENEADELRQTSVVATRYGFGTGSEAAALGGLGVVGPTYMDYSGTISKVSAVARYVSEILAGE
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: ASQL_EMENI
Sequence: MSNGAPFPLDYRGTRNYGPRFIPDRYSTFVSSARKSPRTPPGGSDQVVHVNDAGVYKRTFAVASPFPKSEFFYSSVGVGDAIGAMTDTKKHRVRRSILGPRLRAKAIAPYTPSLQKLVIACMDIMAGKARQGKVINLLRYTRALTVDVISDFTFGRPMGVVNEAEEMPDLLNDLEVFGRHFHILKHFPISRKLLDIIPESFARKLMPLPGFFELREKATTAVNEAVVERQAGKTISNNTDGASFLDLLLNQIDENPSVLVDEGCAFITGGSDTTGFTMENATYLILSHPHILQSLLQELDTSPHIRDTFDLDHILRLPFLTAIIKETLRLYTPAPSPLPRTVPAEGIDVHGHFLPGGTILTHSLYLIHHNPVLFADPKSFKPERWLGTQGKVLEQYYVPFSKGSRSCIGMALAYHEVYTYLSLLFSRFEMEIFETSQSDMDWREHFFVKRNGQLRIRIVRDRWTGEAFPTRAVEADLR
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934).  The role of asqL within the aspoquinolone pathway has still to be determined (Probable).  The first step of the pathway is catalyzed by the nonribosomal pepdide synthetase asqK that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin.  4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ.  AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin.  The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase asqI.  4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B.  The prenyltransferase asqH1 then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase asqF to yield conjugated aryl diene.  The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase asqH2 to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain.  The FAD-dependent monooxygenase asqG performs epoxidation of the terminal C7'-C8' olefin.  Finally, after dehydratation of the epoxide at C3 by asqC, the quinolone epoxide rearrangement protein asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase asqL, 4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqL, Aspoquinolone biosynthesis protein L.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: DUS26_MOUSE
Sequence: MCPGNWLWASMTFMARFSRGSSRSPVRTRGSLEEMPSVHHPFLNVFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHNRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHFTLVEAIKKVKDHRGITPNRGFLRQLLALDRRLRQGLEA
What is the function of this protein?
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity.
What are the official names of this protein?
Dual specificity protein phosphatase 26, Dual specificity phosphatase SKRP3.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Golgi apparatus.
Protein: INSL7_DROME
Sequence: MTRMIIQNSGSWTLCGAVLLFVLPLIPTPEALQHTEEGLEMLFRERSQSDWENVWHQETHSRCRDKLVRQLYWACEKDIYRLTRRNKKRTGNDEAWIKKTTTEPDGSTWLHVNYANMFLRSRRSDGNTPSISNECCTKAGCTWEEYAEYCPSNKRRNHY
What are the official names of this protein?
Probable insulin-like peptide 7, dILP7, Insulin-related peptide 7.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NADA_ECO45
Sequence: MSVMFDPDTAIYPFPPKPTPLSIDEKAYYREKIKRLLKERNAVMVAHYYTDPEIQQLAEETGGCISDSLEMARFGAKHPASTLLVAGVRFMGETAKILSPEKTILMPTLQAECSLDLGCPVEEFNAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIDHLDSLGEKIIWAPDKHLGCYVQKQTGADILCWQGACIVHDEFKTQALTRLQEEYPDAAILVHPESPQAIVEMADAVGSTSQLIAAAKTLPHQRLIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWMAMNGLQAIAEALELEGSNHEVYVDERLLERALVPLNRMLDFAATLRG
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.