PharMolix/UniProtQA huggingface dataset:
Protein: DPOL2_SACS2
Sequence: MGRTQPSYTMAVNRELEKLERIIERLHSPILSLLLERVKEKVRYTQSASYDELVDPYNLVYFALIWALAEECEKMEEYVLDAYPIKGGVKLFLSNFKEKTIRTTFPVYTITDNPDIVLQHPEVRYYEKEKWKTLDGKEVKVYRFEVESLDAYYYMRKRLNVVNETPTVLSQTLYRLGIKPFRRFRSSDDEFPKVTIARVVPLDWYGESLKGKVFEVKINNEVRRFYEKPEVEVDIAECLGEACNYVKSNVKIRIEKKRSPVSAKGLIEWSFISLTPIHEIAYATIGKVLTINEAWVAFKRRIIIPKVVPRVEKLRRLEDIMMVDKGGLILFPQPGCYDNVYQVDFSSMYPSLIVKHNISAETVEACDDIKTELHSICLKEKGIIPEALQWLIERKSELKKIDEERAEAIKWILVASFGYLGYRNSLFGKIEAYEMVTYLARKTLRRTMEIAEEMGLRVLHGIIDSLVVKGDNVDKFIEKVEKETGLRLDYKRYNWIIFTITRNNTPYPTRYIANMNGEMIAKGLIRENMPNIVKSFLEDVLREFSSAKTCSDVKKLRIRDLFEHYRKRAINGEPIDYVIWIKDVPYVRGIKGFYEARLGYMGRDVNYYINYLKRVYEDVEEVMSRC
What is the function of this protein?
This polymerase is devoid of exonuclease activity.
What are the official names of this protein?
DNA polymerase 2, DNA polymerase B2, DNA polymerase II.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: ITA3_HUMAN
Sequence: MGPGPSRAPRAPRLMLCALALMVAAGGCVVSAFNLDTRFLVVKEAGNPGSLFGYSVALHRQTERQQRYLLLAGAPRELAVPDGYTNRTGAVYLCPLTAHKDDCERMNITVKNDPGHHIIEDMWLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCYVRGNDLELDSSDDWQTYHNEMCNSNTDYLETGMCQLGTSGGFTQNTVYFGAPGAYNWKGNSYMIQRKEWDLSEYSYKDPEDQGNLYIGYTMQVGSFILHPKNITIVTGAPRHRHMGAVFLLSQEAGGDLRRRQVLEGSQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAIYVFMNQAGTSFPAHPSLLLHGPSGSAFGLSVASIGDINQDGFQDIAVGAPFEGLGKVYIYHSSSKGLLRQPQQVIHGEKLGLPGLATFGYSLSGQMDVDENFYPDLLVGSLSDHIVLLRARPVINIVHKTLVPRPAVLDPALCTATSCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRRPPRLRFAGSESAVFHGFFSMPEMRCQKLELLLMDNLRDKLRPIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQAQALENHTEVQFQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQYSRDVRKLLLSINVTNTRTSERSGEDAHEALLTLVVPPALLLSSVRPPGACQANETIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLSTSSHQDNLWPMILTLLVDYTLQTSLSMVNHRLQSFFGGTVMGESGMKTVEDVGSPLKYEFQVGPMGEGLVGLGTLVLGLEWPYEVSNGKWLLYPTEITVHGNGSWPCRPPGDLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSETVLTCATGRAHCVWLECPIPDAPVVTNVTVKARVWNSTFIEDYRDFDRVRVNGWATLFLRTSIPTINMENKTTWFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCGFFKRARTRALYEAKRQKAEMKSQPSETERLTDDY
What is the function of this protein?
(Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R. delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.
What are the official names of this protein?
Integrin alpha-3, CD49 antigen-like family member C, FRP-2, Galactoprotein B3, GAPB3, VLA-3 subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the integrin alpha chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid- anchor. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner.
Protein: SCAF_BPPH2
Sequence: MPLKPEEHEDILNKLLDPELAQSERTEALQQLRVNYGSFVSEYNDLTKSHEKLAAEKDDLIVSNSKLFRQIGLTDKQEEDHKKADISETITIEDLEAK
What is the function of this protein?
Scaffolding protein involved in the icosahedric procapsid assembly.  Coassembles with the capsid proteins to form the procapsid.  The scaffolding protein is found within the capsid as a serie of concentric shells.  During DNA packaging, the scaffolding protein molecules are released from the procapsid.
What are the official names of this protein?
Capsid assembly scaffolding protein, Gene product 7, gp7, Head morphogenesis protein, Protein p7, Scaffold protein.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus scaffolding protein family.
What are the subcellular locations of this protein?
Note=Present in about 147 copies in the prohead but not present in mature virions.
Protein: RL6_DESDA
Sequence: MSRIGKLPIPVPNGVEVKIGTDVVEVKGPKGSLSTPVCSLLQYEQADGHVVLTRIEDDRVTRAQHGLRRSLLSNCIDGVTKGFSKALEVIGVGYRVAVKGNIIELQVGYSHPVLVELPEGLKATVEGQVLTISGIDKELVGEMAARIRRIRKPEPYKGKGIKYATETIRRKVGKSGGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ATPA_BARHE
Sequence: MDIRPSEISKILKEQIKNFDQKAEVSEIGWVLSVGDGIARVYGLDNVQAGEMVSFSNGVRGMALNLEIDNVGVVIFGSDRDIREGDCVKRLGAIVEVPVGPALLGRVVDALGNPIDGKGPLKATEYRRVDVKAPGIIPRQSVHEPMSTGLKAIDALIPIGRGQRELVIGDRQTGKTAILLDAFLNQKPFHEKDAGNEKDKVYCIYVAIGQKRSTVAQFVKVLEERGALEYSIIVAATASDPAPMQFIAPLAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNAENGSGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETNLFYQGIRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDASTQRLLNRGARLTELLKQPQFSPLKTEEQVVVIFAGVNGYLDALAVADVGRFEQGLLTLLRSDHSDLLQAIADQKQLTDDIKDKLIVVLNTYAKNFS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ZAT12_ARATH
Sequence: MVAISEIKSTVDVTAANCLMLLSRVGQENVDGGDQKRVFTCKTCLKQFHSFQALGGHRASHKKPNNDALSSGLMKKVKTSSHPCPICGVEFPMGQALGGHMRRHRNESGAAGGALVTRALLPEPTVTTLKKSSSGKRVACLDLSLGMVDNLNLKLELGRTVY
What is the function of this protein?
Transcriptional repressor involved in light acclimation, cold and oxidative stress responses.  May regulate a collection of transcripts involved in response to high-light, cold and oxidative stress.
What are the official names of this protein?
Zinc finger protein ZAT12, Protein RESPONSIVE TO HIGH LIGHT 41.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIUH_BRUME
Sequence: MGKLSTHVLDTAHGTPAAAMRVELYRIAASGTPELLKRVVTNLDGRTDAPLLSGDEMRTGIYELQFHVAEYFEGRGAELAHEPFLDLIPIRFGIADEDGNYHVPLLVSPWSYSTYRGS
What is the function of this protein?
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
What are the official names of this protein?
5-hydroxyisourate hydrolase, HIU hydrolase, HIUHase.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
Protein: ACBP_MANSE
Sequence: MSLQEQFDQAASNVRNLKSLPSDNDLLELYALFKQASAGDADPANRPGLLDLKGKAKFDAWHKKAGLSKEDAQKAYIAKVESLIASLGLQ
What is the function of this protein?
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
What are the official names of this protein?
Acyl-CoA-binding protein homolog, ACBP, Diazepam-binding inhibitor homolog, DBI.
What is the protein family that this protein belongs to?
Belongs to the ACBP family.
Protein: GATB1_CLOAB
Sequence: MEYEIVIGLEVHAELATKTKMYCGCTAEFGGQPNTHVCPVCMGLPGALPHINKRAVDYGIKAGLALNCSITHIGRMDRKHIFYPDNSRNYQITQDELPLCTNGYIEIELEDGSKKKIGVERIHIEEDAGKLLHTNAGTLVDFNRCGVPLAEIVSKPDMRSPREAVTYLEELKSILSCVGVSDCKMEEGSLRCDANISVMKKGAKEFGVRTEIKNMNSFKAVEKALNYEYERHIKAIESGEKLTQETRRWDDAKNETAPMRSKEEANDYRYFPEGDLVTLNIDDEWIESIRKTIPELPYQKRERFIKEFGIPKYDASVLTLTMSMADFFEKTAKISGDAKSASNWLMGDISKIMKENYVWIEDLKFTPEQLSELIKLINEGTVSNAIGKKVIIKMFETGKSPKNIIEEEGLIQNSNEDEILNIVKEVLSENEKSIEDYKNGKNRVVGFLIGLVMKKTKGKANPKIVNKLMIDELNKQ
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B 1, Asp/Glu-ADT subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: MPM1_YEAST
Sequence: MGFYEGDDNDANTKAFNDKYIKDQKFATAPFWNLFPKLRDIDEYDNPLLPLPFNFNFRDLGDSALAMASGIPTVKQFDKCEELKGQSAWTTQGIWKCLVPSKAIPPLPQLDFLLPLEEIKSDKSHSHGLFFNDFNLFLKWRSHMNRLQKQRIKTRSTAVEPLARTPEDLMLNWDDLHLGNDAEYASADGSKKIVGRAQSISTTKDSNDAKPSTVKTEKIYFDDGTVDITTTTTSKGSSPQVKHKVVSVDEDN
What are the official names of this protein?
Mitochondrial peculiar membrane protein 1.
What are the subcellular locations of this protein?
Mitochondrion membrane; Peripheral membrane protein; Intermembrane side.
Protein: RACC_DICDI
Sequence: MSAAEVIKLVVIGDGAVGKTCLLISYANNRFPEDYIPTVFDNYVVNLTAGDRNIELGLWDTAGQEEYDKLRPLSYANANVFLICFSITNPVSFENVYTKWYPEVMHFCPEVPQILVGTKLDTRDDRGVLDKLQQTGHKPITTEQGNDLARRIKAIKYMECSAKTSQNLKQVFDEAIKSVLFIKKKKSKCIVM
What are the official names of this protein?
Rho-related protein racC.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: Y4PA_SINFN
Sequence: MADPIVHPGVHRPEFSAPLHARAEIIATLRAALGKPNTTLVGAAIGTGMAAQAASRGGADFILALNAGRLRSMGAPSIFSLLALRKSNDFVLDFAQSEILPFVKVPVFFGASAFDPRCSIEAELERIADAGFGAIVNFPTSIFLDGRFRADIEGAGLGFQRELEMLRAAQKRNMATLAYVRTVAEAQQAATAGVDIINLNLGWNVGGTVGSRTELSLRQAAEYAKIIFRQIRAISEDTLCVLEGGPIVSPDQMYEVSALSKADGYIGGSTIDRVPLEASMEQITSAFKSVGTLQKRIDELERQLEHVQREYSIVGRSPSIQQIKQRIEKLAASSLPVMITGQAGTGKKLLARGIHEAARRSGSKLISSEDASGESLFGFAPSEGGRKVLGLLQYHPKATLLIESVECLCVDAQERLIEVIETGAYRRLGDNERGRFEGRLILASTRPLPELGSSGQLIPALESRLAPGHVFLPPLCDRLEDLPLLAEHFLQALRKDRRSRKLSVDHSAYRVLMTYGWPENIRELRSVLETAAIRCEGDWIKSEHLPPLGDANADAPHPHPGEEREWILDALQRHRFRRGEAARYLGISRKTLYNKMRVYGLPLQPRERS
What is the function of this protein?
Probable transcriptional regulator that acts in conjunction with sigma-54.
What are the official names of this protein?
Putative transcriptional regulatory protein y4pA.
Protein: MROH7_MOUSE
Sequence: MALSRGTSLILHEDPEKIPSPNSCEVPGIMSNTTPRPTPDLALAPPPEHALALTPALHPALSPDPEGVSGPVSNDIPSHNASGATTPSSTQINTVDTADQGLNHTSGPDAAGTLCPDSQPARIPSSTQANVLSPENSSRPCSEDVSKSFSSKVFGLGQSNSNPSRPEPNLYIKALSREALVRSHNISRQGSQVPLLLPSNTSLDRLHSGNISKVNLGIAPNSNEAITLTSHTIFASISKEALSAPWNTGSKGSINGTSTIQPRSGLNVTVTHASHVSMIPGSSEGLSLQSSARVPNSTLSPSSCMTLIMDSESPSMDSSFLVTDTSTLTLSSHRDYSEDNSIRTMPLEENLGKWDSLQGVTALQSPPEGTSEDVKVNEAEKRNHDNKAALVANIITYQKNQEMVEMKEEKEATVKMMMRQIQEEPLDSLLSPARRQAMEILAQLSHTKPILSVRERVELVNTCVRSVFSLPSVQAMQEKDESKAEVIQILYYQTLDSLQKLLNALFIEDPTPTGLKSILEPLGPWMNSGKAHERARAVNSNVSVLNHTLVTLPFLISSGFPTLGLLLGRLLLRIGDPDEEIGREALDGITILYTILDLQKRTKNKEDTNKKELYENNKRFLGPYNPVSPCQNILRVIAEFGDFLGPQQVRDLLLAALEGLKGISETQGKDSGEMMQLASEVMLSSVLEWYRHRALEVIPEIMQGIYMQLTHIQEPRAREVALLPISFLASSFMTEVVVALLMCPLPLDSNGAEMWRQLILRKPSCDVRDLLDLLLTSLKEKPVTKKGRASIVPLAAASGLCELLSVNSCVGRVRRIYPQLLLALLIQVHYHIGLNLPSRMAPRKDSKDDTQPPLFIPVRWMVKVVKTLLLKMGCSYESAFLEEQGGWELMGQAESHYRGVSLLARAMVHYSCQELCRILYLLIPLLERGDERHKITATAFFVELFRMEQVRRIPEEYSLGRMVEGLSHRDPIMNVLSIRGLVILACKSEKMAKVQSLLPSMVKSLKNMDGMLVVEAVHDLKRIFKGQGKKLTDSAVYVEMLQILLPHFTDAREMVRASCINVYGKVVKKLQTPRTQAMEEQLTSTLMPLLFIIQEGNAKVSQKCVKTLVCCSSFMNWELPKKAYSQKPWDNQQLTVTKICKYLVSSHRDNVFTFLNQSLEYAKNSRASLRKSSVIFIGSLVPCMENMMTEERLNEVKATLEILRHDPEASVCICAAQAQDQIMATCWRNSWPLLYGDSWVCDPSSMHRWSPSCENLPTSHQRRSWIMQALASWKMSLKQ
What are the official names of this protein?
Maestro heat-like repeat-containing protein family member 7, HEAT repeat-containing protein 8.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: EFP_MARSD
Sequence: MISTKDFRNGLKIEIDGKPYEIVEFQHFKPGKGGAFVRTKLRNMFTGRITDQTFRSGEKVKKPDMATKEMQYLYKDGEDYVLMDLESYEQMNVAADVIATAGGFLKEGETNKALLYNGEVIGIELPASVILEVTQTDPGVQGDRVSNATKPATLETGLGINVPLFINEGDKIKVDTRSSEYLGREK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_MYCLB
Sequence: MFSSQHRLLYQPSGPDLSKNLDPERGRRLGIDVGSVRIGVAFSDPDGILATPVETVRRYRSAKHLRRLAELVVELQVVEVVVGLPWTLTDRTGSSAKDAIDTAEALARRVAPVPVRLVDERLTTVSAQRLLRAAGVRAKDQRAVIDQAAAVVILQNWLDQCRAATPARADEPTTGSVAGEVIDG
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL10_MOUSE
Sequence: MPGSALLCCLLLLTGMRISRGQYSREDNNCTHFPVGQSHMLLELRTAFSQVKTFFQTKDQLDNILLTDSLMQDFKGYLGCQALSEMIQFYLVEVMPQAEKHGPEIKEHLNSLGEKLKTLRMRLRRCHRFLPCENKSKAVEQVKSDFNKLQDQGVYKAMNEFDIFINCIEAYMMIKMKS
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity) (PubMed:28473584).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL39_CAEEL
Sequence: MSALKKSFIKRKLAKKQKQNRPMPQWVRMKTGNTMKYNAKRRHWRRTKLKL
What are the official names of this protein?
60S ribosomal protein L39.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: DRM_ANOGA
Sequence: MFAVMRIDNDDRRADFRRKMRPKCEFVCKYCQRRFTKPYNLMIHERTHKSPEVTFSCEVCGKYFKRQDNLRSHRCSQCIWR
What is the function of this protein?
Putative transcription factor.  May function redundantly with odd and sob in leg joint formation during the larval stages, acting downstream of Notch activation (By similarity).
What are the official names of this protein?
Protein drumstick.
What are the subcellular locations of this protein?
Nucleus.
Protein: MHPD_ECO55
Sequence: MTKHTLEQLAADLRRAAEQGEAIAPLRDLIGIDNAEAAYAIQHINVQYDVAQGRRVVGRKVGLTHPKVQQQLGVDQPDFGTLFADMCYGDNEIIPFSRVLQARIEAEIALVLNRDLPATDITFDELYNAIEWVLPALEVVGSRIRDWSIQFVDTVADNASCGVYVIGGPAQRPAGLDLKNCAMKMTRNNEEVSSGRGSECLGHPLNAAVWLARKMASLGEPLRAGDIILTGALGPMVAVNAGDRFEAHIEGIGSVAATFSSAAPKGSLS
What is the function of this protein?
Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.
What are the official names of this protein?
2-keto-4-pentenoate hydratase, 2-hydroxypentadienoic acid hydratase.
What is the protein family that this protein belongs to?
Belongs to the hydratase/decarboxylase family. MhpD subfamily.
Protein: TKT_POPEU
Sequence: ALPTYTPESPADATR
What is the function of this protein?
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
What are the official names of this protein?
Transketolase, TK.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: ARGC_RENSM
Sequence: MKISVAVSGASGYAGGEVLRLLANHPQVQIGAITAHSNAGSRLGELQPHLYSLADRLLEENSVANLAGHDVVFLALPHGASGEIAAQLPAETLVIDAGADHRLVYAGAWQEFYHSEHAGTWPYGLPELPIAHGRRQREELRTTKRIAVPGCYPTSALLALAPGFAAGALLADDVVIVSASGTSGAGKAAKTNLLGSEVIGSMAPYGVGGVHRHTPEIEQGLSSVAGEQVTVSFTPTLAPMSRGILTTATAKVAPQLLKETSAAQLRQIWVDAYEDEEFIHVLPEGQWPATQSVLGSNHVGIQVALDERTGRVIVCSVIDNLTKGTAGAAVQSMNIALGLEENLGLKQLGVAP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_SQUAC
Sequence: MTTNIRKTHPLIKIVNHALVDLPSPSNISIWWNFGSLLGLCLIIQILTGLFLAMHYTADISTAFSSVVHICRDVNYGWLIRNIHANGASLFFICVYLHIARGLYYGSYLFKEAWNIGVILLFLLMATAFVGYVLPWGQMSFWGATVITNLLSAFPYIGDMLVQWIWGGFSIDNATLTRFFAFHFLLPFLIVGLTLIHLLFLHETGSNNPMGLNSDMDKISFHPYFSYKDLLGFFLMIILLALLALFLPNLLGDAENFIPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLFSIFILMLIPMLHTSKQRSNIFRPMTQFLFWTLVANAIILTWIGGQPVEQPFILVGQIASVTYFSLFLIIIPLTGWWENKMLNLN
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y388_SHEB9
Sequence: MGIKDWPEGEGPRDKLLQKGAGQLSDAELLAVLLRNGLAGLNAVDLARSLISEFGGLRNLLCAPRNQVCRLPGVGPVKYAQLQAAAELARRVAQENLQRGQVLTNPDLTRDYLMRQLADRSYEVFAVLLLDSQHRVIQFVELFRGTIDSASVYPREVVSLVLEKKAAAVIVCHNHPSGIAEPSQADRRITERLKNALATIDVSLLDHMVVGDREIVSFAERGWIN
What are the official names of this protein?
UPF0758 protein Sbal195_0388.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: IXTPA_ACIAC
Sequence: MKLVLASNNRGKLAELQSMFSPLGVELVRQADLGVGEADEPFHTFVENALAKARFAAEHTGLPALADDAGLCVDAFGGQPGVQTAYYATRFGYEKGDANNVRALLEQMRGVASRRAAMVSTLVAVRSPDDPEPLIAVGRVVGEIATEPRGDGGFGFDPVMFIPEFGKTFAELPVEVKNAHSHRGRSAQQMLALMRERWF
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: CD3G_MACFA
Sequence: MVQGKGLTGFILAIILLQGSLAQSFEENRKLNVYNQEDGSVLLTCHVKNTNITWFKEGKMIDILTAHKNKWNLGSNTKDPRGVYQCKGSKDKSKTLQVYYRMCQNCIELNAATILGFVFAEIISIFFLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRMN
What is the function of this protein?
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.  When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.  All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.  Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.  In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface.  Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
What are the official names of this protein?
T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RL31B_XANOM
Sequence: MKDNVHPNYKDVVFHDVTSDFKILTRSTMTSKETVKWEDGQEYPLIKVEISSSSHPFYTGKHKVIDTGGRIDKFQKRYAR
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: GLNA3_LUPAN
Sequence: MSLLSDLINLNLSDTTEKIIAEYIWVGGSGVDLRSKARTLSGPVNDPSKLPKWNYDGSSTGQAPGKDSEVILWPQAIFKDPFRRGNNILVICDTYTPSGKPIPTNKRHAAAKIFSHPDVAAEEPWFGIEQEYTLLQKDIHWPIGMALGGFPGPQGPYYCGTGAEKAFGRDIVDSHYKACLYAGINISGINAEVMPGQWEFQVGPSIGISAGDELWVARYILERITEIAGVVLSLDPKPIPGDWNGAGAHTNYSTKSMRNDGGYEVIKQAIEKLEKRHNEHIAAYGEGNERRLTGRHETADISTFSWGVANRGASI
What are the official names of this protein?
Glutamine synthetase nodule isozyme, Glutamate--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M2_I56A2
Sequence: MSLLTEVETPIRNGWECRCSDSSDPLVIAASIIGILHLILWILDRLFFKCISRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).