PharMolix/UniProtQA huggingface dataset:
Protein: VPS34_SCHPO
Sequence: MDRLVFSYCPSSKVTARFLVKFCFIEYQDSQEPCICTIQLFSGNESGSLMQKCFVSKIPNKSLLPTELSKISTHEWLDFGVTVSELSLNAKFVVSAWKPSFNDEEVYEFVGCTTYRLFDENNLLRQGLQKIPLQTSKEIKKYSPTSLELEQVKEINRLDGLLLKLQLGDVPSVNWLDDISFGKIKDFRSKHMSLVTIPILYLDFLQFSFPVVFQRSYYPKSENRVYYSSFDLELNLDSPAELKHRRLVRSQRNGPLDKDLKPNSKIRKELESILSYPPSEELSLEEKDLIWKFRFYLTRNKKAMTKFLKSVVWTDSSEVNQALSLLDSWTEIDIDDALELLSPSFVHPKVRAYAVSRLETASNEELLLYLLQLVQALRYDNPISSDERFQPSPLALFLVNRAISSPSIGNDLYWYLVVEIEDEPVSKLFSSVMFLFQKELSKSVEGRLIRETLSAQAKFVEKLLRISKSVQSFRGTRLKKIEYLKVLLEDHKYHLLDFHALPLPLDPSVNIVGIIPDACTVFKSTMQPLRLLFKCQDGSKYPIIFKNGDDLRQDQLVIQILTLMDKLLKKEKLDLHLKPYRILATGPTHGAVQFVPSKTLATILAEYHGSVLAYLRENNPDDGLNSANYGIDPVAMDNYVRSCAGYCVITYLLGVGDRHLDNLLITKDGHFFHADFGYILGRDPKLFSPAMKLSKEMVEGMGGYNSPFYQQFKSYCYTTFTALRKSSNLILNLFSLMVDANIPDIKFDKEKVVYKVKERFCLQMSESDAIKYFEQLINDSVSALFPQIIDRMHNLAQYMRS
What is the function of this protein?
Phosphatidylinositol 3-kinase homolog required for vacuolar sorting and segregation.
What are the official names of this protein?
Phosphatidylinositol 3-kinase vps34, PI3-kinase vps34, PI3K vps34, PtdIns-3-kinase vps34, Vacuolar protein sorting-associated protein 34.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family.
Protein: MURA_SORC5
Sequence: MDSIRIRGGKPLSGKIRISGAKNAALPILCATLLSDGESLLRNVPALRDIETTSALLRFLGRNVETAPPLVKVGAGDNVRPEAPYELVKQMRASVMVLGPLLARFGRAKVSLPGGCQIGTRPVDQHLKGLEALGATIRLSRGYIVAECKRLRGAEVVFDLPTVTGTENLMMAAALAKGRTTLVNCAREPEVEELGRVLNKMGARVSGAGTDVIHIEGADELEPFDHAIISDRIEAGTYMVAAAAAGGDVLIENAPLEDLEAVAAKLRQAGVEVGREGDCVRVRREGRPLRAVDVTTAPHPGFPTDMQAQFMVLMCLAQGTSRIVETIFENRFMHVPELARMGAHIDVDGHTAHVHGGAPLSGATVMATDLRASASLVIAGLVATEGETEVLRVYHLDRGYEFMERKLAQLGADTARVEGRDG
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_CORGL
Sequence: MKITAKAWAKTNLHLGVGPAHDDGFHELMTVFQTIDLFDTVTLTTLDEELVEEGSVVKQLSVTGARGVPEDASNLAWRAVDALVKRRAEKTPLSAVSLHISKGIPVAGGMAGGSADAAATLRAVDAWIGPFGEDTLLEVAAELGSDVPFCLLGGTMRGTGRGEQLVDMLTRGKLHWVVAAMAHGLSTPEVFKKHDELNPESHMDISDLSAALLTGNTAEVGQWLHNDLTSAALSLRPELRSVLQEGIRSGAHAGIVSGSGPTTVFLCESEHKAQDVKEALIDAGQVYAAYTATGPAASTADQRGAHILTVS
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: NA122_ACTEQ
Sequence: MNRLMILVFAAVFLALASADEDVDIAKRGVPCLCVSDGPRPRGNNLSGIMWMKTGGYGGNGCPKGWHFCGKSRGFFSDCCKR
What is the function of this protein?
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction.  Causes death to crabs.
What are the official names of this protein?
Delta-actitoxin-Aeq2b 2, Delta-AITX-Aeq2b 2, Ae2-2, Neurotoxin 2-2.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RL18_VIBVY
Sequence: MDKKASRIRRATRARRKIAELGATRLVVHRTPRHVYAQVIAANGSEVIAAASTVEKAIREQVKYTGNIEAAKAVGKAVAERALEKGVSTVAFDRSGFQYHGRVAALADSAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RPN51_SCHPO
Sequence: MEQKPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLFRAGDFQGLNEQLVSLFKKHGQLKQSMTSLVQHVMTYLPGIDDLKTKINLIETLRTITDGKIYVEVERARLTQLLSQIKEEQGDIKSAQEILCNEPVETYGSFDLKEKVAFILDQVRLFLLRSDYYMASTYTKKINVKFFEKEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYDTAVVQEDPEKWKEILENVVCFALLTPYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELMRWPKIAEIYGSALRSNPVFAENDEKGEKRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKSQNVQEQLNEWGSNITELLGKLEKVRQLIIKEEMMNSIQQAVAK
What is the function of this protein?
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.  Required for proper proteasome assembly.
What are the official names of this protein?
26S proteasome regulatory subunit rpn501.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit p55 family.
Protein: TBXT_MOUSE
Sequence: MSSPGTESAGKSLQYRVDHLLSAVESELQAGSEKGDPTERELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVTADNHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNDHKDVMEEPGDCQQPGYSQWGWLVPGAGTLCPPASSHPQFGGSLSLPSTHGCERYPALRNHRSSPYPSPYAHRNSSPTYADNSSACLSMLQSHDNWSSLGVPGHTSMLPVSHNASPPTGSSQYPSLWSVSNGTITPGSQTAGVSNGLGAQFFRGSPAHYTPLTHTVSAATSSSSGSPMYEGAATVTDISDSQYDTAQSLLIASWTPVSPPSM
What is the function of this protein?
Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation (PubMed:7588606).  Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site (PubMed:8344258, PubMed:7588606).
What are the official names of this protein?
T-box transcription factor T, Brachyury protein, Protein T.
What are the subcellular locations of this protein?
Nucleus.
Protein: KCY_METSB
Sequence: MIIAIDGPAASGKGTLARRLAAHFGLPHLDTGLLYRATARALLDHGHDLSDREAAISAARSLALTDFDEAGLRSRDMAEAASVVAAIPEVRAALVDMQRRFAGRPGGALLDGRDIGTVICPDADCKIFVTASDEARATRRALELRGRGEKVDYAAVLEDIRKRDLRDSSRAAAPLKPADDAVVLDTTKLDVEAAFKAALVIVESAHDSLRAGHPAF
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_PECCP
Sequence: MFYPVIKKALFQLDPERAHELTFQQLRRITNTPFEFLVRQSVPTKPVTCMGLSFKNPLGLAAGLDKDGECIDALGAMGFGFIEVGTVTPRPQSGNDKPRLFRVVEAEGLINRMGFNNKGVDSLVENVKKTRFGGVLGINIGKNKDTPVEQGKDDYLICMDKVYAHAGYIAINISSPNTPGLRSLQYGEALDDLLLAIKNKQAELKERHQKYVPVAVKIAPDLSEEELIQIADSLVRHNIDGVIATNTTLDRKLIQGLNHCGQTGGLSGRPLQTSSTEIIRRLSQELAGRLPIIGVGGIDSLVAAREKMAAGASLVQIYSGFIFHGPRLIKDIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YFIA_SHIFL
Sequence: MTMNITSKQMEITPAIRQHVADRLAKLEKWQTHLINPHIILSKEPQGFVADATINTPNGVLVASGKHEDMYTAINELINKLERQLNKLQHKGEARRAATSVKDANFVEEVEEE
What is the function of this protein?
During stationary phase, prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases.  In addition, during environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation initiation and increase translation accuracy.  When normal growth conditions are restored, is quickly released from the ribosome (By similarity).
What are the official names of this protein?
Ribosome-associated factor Y, pY, Ribosome associated inhibitor A.
What is the protein family that this protein belongs to?
Belongs to the HPF/YfiA ribosome-associated protein family. YfiA subfamily.
Protein: RS3_MYXXD
Sequence: MGQKVHPIGFRLGVIKTWDSKWFEHKNYAQWLHEDIRIREFVKKSLNHAGVSKVEIERAANKVKVNVHTARPGIVIGKRGAGIETVKKDLQQFTKNEVFLNIVEVRKAETDAQLVAENIATQLERRIAFRRAMKKALQTAMKFGAKGIRVACSGRLGGAEMARYEWYREGRVPLHTLRADIDYGFAEAKTTYGKIGCKVWVCKGEVLPGKGGQAPMPSNR
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RL15_ACIET
Sequence: MELNSIKPADGAKHAARRVGRGIGSGLGKTAGRGHKGQKSRSGGYHKVGFEGGQMPLQRRLPKRGFKSHLLKFNAEISLTALENLGLAEVDVLALKNAGLVGELAKVVKVIKSGEISKAVKLSGITATAGAKAAIEAAGGSLA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ZN142_MOUSE
Sequence: MTDPVLASQLANGTGEMDGLCSELLLIPPPLSNHGILGPVQNTCASGELAPLPADPGCLLVEATATEEGPGNMEIIVEAVTGTLSPGAPEETSGVLVKVVEVYFCERCEQSFAEPTLLSVHQCTETHIQAVQDLSSPPCSVELPPSNLALRGPLQDPSLPDSPLPCPVCRQEFVQPQALKSHFKIHRVTPNMFSCPESGCVFSAEDRKGLQNHLRQTHKAVPVPCSFRGCSLLFGSQQGMELHRQAHYPFHCSHCSFMGSNVKLFRQHQRSHGASARGELSAAVQGLPSQELLPAAKLPPGHREPSEEASTPLPGQESAEEEDAEEEESVTQKDSQKVMDKSQGAQQLEGHVGSGTESLFKTHMCPECKRCFKKRTHLVEHLHLHFPDPSLQCPNCQKFFTSKSKLKTHLLRELGEKAHRCPLCHYSAVERNALNRHMASMHEDISNFYSDTYACPVCREEFRLSQALKEHLKSHTAAAAAEPLPLHCFQEGCTYVAPDRKAFLKHLKEIHGVRAVECRHHSCPMLFATAEAMEAHHKSHYAFHCPHCDFACSNKHLFRKHKKQGHPGSEELRCTFCPFATFNPVAYQDHVGKMHAYEKIHQCSECNFATAHKRVLIRHMLLHTGEKPHKCELCDFTCRDVSYLSKHMLTHSNTKDYMCTECGYVTKWKHYLSVHMRKHAGDLRYQCNQCSYRCHRADQLSSHKLRHQGKSLMCEVCAFACKRKYELQKHMASQHHPGTPAPLYPCRYCSYQSRHKQALLSHENCKHTHLREFHCALCDYRTFSNTTLFFHKRKVHGYMPGDQVWQFCNASQELEGARQCLAPPSDSGPSSQLSAQPEREDREHEIVANSNMDQALPETNEEASPKRQDGIEAPQEDDQVDSPSLGEVEEGGCTLHLEALRVELEPETEPLPLEELTETATVEFRPLDPSGPLGTERPGGLEEPALSSFDSIETPALVAEEEPVVEKLASEPPRNPLISEEAPNTFKAALTAETVPLPPFPESESLLKAMRRQDKEQAEALVLEGRVQMVVIQGEGRAFRCPHCPFITRREKALTLHSKSGCQGRREPLLCPECGASFKQQRGLSTHMMKKCPVLLKKNKALPKPVSPTLHPQLPDNQASQDAESRKPPPLPSKVELLLPKDAPSDLPGGPGVEEPLPTPSDFPTSPPENSLPTGTSEKFHFEQGKFHCSSCTFLCSRLSSITSHVTEGCRGGRGQKRKRGRPQTHAVVLPLNNGDSTLLNTGSTESSPSDGDTAVVQKQKGALFSCPTCPFSCQQERTLRTHQTQGCPLKSGDLHCGLCPFTAPAAAALRLHQKRRHPTASPASGPRPLLQCGDCGFTCKQSRCLQQHRRLKHEGVKPHQCPFCDFSTTRRYRLEAHQSRHTGVGRIPCSSCPQTFGTNSKLRLHQLRVHDKTPTHFCPLCDYSGYLRHDITRHVNSCHQGTPSFSCTQCEAQFSSETALKQHALRRHPEPTPPSSGCPVEVTEGPLHCSHCGLLCPSPASLRGHTRKQHPRLECGACQESFPNRPALDEHRRQHHFSHRCQLCSFAARERVGLVKHYLEQHEESSTAPSDGDAGQPSLCCPFCDFACRHQLVLDHHVKGHGGTRLYKCTDCAYSTKNRQKITWHSRIHTGEKPYHCHLCAYACADPSRLKYHMRIHKEERKYLCPECGYKCKWVNQLKYHMTKHTGLKPYQCPECEYCTNRADALRVHRETRHREARAFMCEQCGKAFKTRFLLRTHLRKHSEAKPYVCNVCHRAFRWAAGLRHHALTHTDRHPFFCRLCSYKAKQKFQVVKHVRRHHPDQADPNQGVGKDPTTPTVHLHDVKLEDPSPPAPPAPSTGPEG
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 142.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TIG_SYNP2
Sequence: MKVIQEKLPASQVGLEIEVPADVTQKAYDDTVRKLARTVNLPGFRKGKVPKQILIQRLGPNRIKASVLEDLIDDSLKAAIAQENIEALGNFQLKSSFDDLISAYKPGEASSFKAAVDVPATVTLNSYKGLSFKAEKSEYDPADLDEFLTQKQRELATLVPVEDRAAQMGDVAIADYEGRYVNDAGEEEEDIIPGTQAEDFSLDLEEGKFIPGFVDGFVGMKPEETKKFTVTFPEDYGNEEMAGKQVSFTVTLKELKSRELPELDDEFASEATNEEFETLAAWQESLEAQLKENAEISTKNSVRRYLLEQLAANNSTELPEVSVNEEITAVLTQQMMEFSRMGIDVNRIFTKDMIPKLRETARPEAEQRLSNSLILTEIAKVEKIEIDTDKFNERLEEAKAELQEGFDEERLQEAIKEELTIDATLDWLEEQSEIEFVPAGTLEAEEAEAANGEE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: SEPF_LEUMM
Sequence: MALGDTIKRLFSNEEDDYYEEDGYEQSQQQEQQTTQQTSSQPRFVRQTTQSQTPAGLNSANSKIALFEPKVYSDSRSIASQILGGEAAIVNFTQIDEAQAKRILDFLGGTIYAVNGEIERIGQSIFLVTPNTFEISGTLTDNLEPNSRY
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: S100G_MOUSE
Sequence: MCAEKSPAEMKSIFQKYAAKEGDPDQLSKEELKLLIQSEFPSLLKASSTLDNLFKELDKNGDGEVSYEEFEAFFKKLSQ
What are the official names of this protein?
Protein S100-G, Calbindin-D9k, S100 calcium-binding protein G, Vitamin D-dependent calcium-binding protein, intestinal, CABP.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
Protein: RM04_VANPO
Sequence: MLNVQRGLHTTVRLSARTKYTKPKPKPQARVIKSEPSQVTHHDNNLKIRAPIPPSAKNIVCPEDHPLWQFFADKKFLRDRADLDNHSRPWTIPELRRKSFEDLHSLWYTSLKERNILARENHLLKTAVESSDDSFEKVADKVRTTMWRIRHVLSERDWSYRIANEAFVEEVDSFVQEFEKDFLLLSQDEDEEAFEQLSRFQKSIFGISEFIDENVVNKRFIDGMKLIANLKVKKFSERNNDIKTFLDQTPNNKITDAGEAFLVFTCENTEKDVKEACEAVLELRNNGNAVSRYDELDTVAEYVNRLAQAQSQATQPVSEQSS
What are the official names of this protein?
54S ribosomal protein L4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: KCNC4_MOUSE
Sequence: MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGGGAGPGDEAGDDERELALQRLGPHEGGSGPGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIHRVGNITSVRFRREVETEPILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPPQLESPIYCKSEETSPRDSTYSDTSPPAREEGVVERKRADSKQNGDANAVLSDEEGAGLTQPLALAPTPEERRALRRSGTRDRNKKAAACFLLSAGDYACADGSVRKEGNVEPKACVPVSHTCAL
What is the function of this protein?
This protein mediates the voltage-dependent potassium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).
What are the official names of this protein?
Potassium voltage-gated channel subfamily C member 4, Voltage-gated potassium channel subunit Kv3.4.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MNTP_ECO81
Sequence: MNITATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGMGMLASRFVLEWNHWIAFVLLIFLGGRMIIEGFRGADDEDEEPRRRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGSIIGKKAEILGGLVLIGIGVQILWTHFHG
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Probable manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CSC1_RAT
Sequence: MTASPESMGQKFRNMTANECFQSRSTVLQGQPFGGIPTVLLLNIILWVCVVLVYSFLRKAAWDYGRLALLIHNDSLTSLIYGEQSEKSSPSEVYLEAERRDKGFSTWFFNSLTMRDRDLINKCGEDARIYIMFQYHLIIFVLILCIPSLGIILPVNYIGSALDWSSHFGRTTIVNVSTESQFLWLHSIFAFMYFLTNFAFMGHHCLGFVPKKNLHFTRTLMITYVPTEIQDPETISKHFHEAYPGCVVTRVHFCYDVRNLIDLDDQRRHAMRGRLYYTAKAKKTGKVMIKVHPCSHLCFCKCWTCFKEVDAEQYYSELEEQLTDEFNAELNRVQLKRLDLIFVTFQDARTVKRIHNDYKYINCGRHPMQSSVTTIVKNNHWRVARAPHPKDIIWKHLSIRRFSWWARFIAINTSLFFLFFFLTTPAIIINTIDMYNVTRPIEKLQSPVVTQFFPSVLLWAFTVIMPLLVYFSAFLEAHWTRSNQNLIIMYKCYIFLVFMVVILPSMGLTSLDVFLRWLFDIYYLEHATIRFQCVFLPDNGAFFINYVITSALFGTGMELMRLGSLCTYCTRLFLSRSEPERVHIRKNLAMDFQFGREYAWMLNVFSVVMAYSITCPIIVPFGLLYLCMKHITDRYNMYYSYAPTKLNAQIHMAAVYQAIFAPLLGLFWMLFFSILRVGSLHSITLFSLSSIIISVIIAFSGVFLGKFRIAQQYEQPEEETETVFDVEPSSTTSTPTSLLYVATVLQEPELNLTPASSPARHTYGTMNSQPEEGEEESGLRGFARELDPAQFQEGLELEGQSH
What is the function of this protein?
Acts as an osmosensitive calcium-permeable cation channel (By similarity).  Required for the functional integrity of the kidney glomerular filtration barrier (PubMed:30900988).
What are the official names of this protein?
Calcium permeable stress-gated cation channel 1, Transmembrane protein 63C.
What is the protein family that this protein belongs to?
Belongs to the CSC1 (TC 1.A.17) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CLPB_MYCGE
Sequence: MNINFTPAGENRNFLQEIGRNINDEVLKNKVDPIIGRDNEIRRLIEILSRKSKNNPVLIGEPGVGKTAIVEGFVRRVVSNDVPLNLRDVEIYELSLSGLIAGTKFQGEFEKRINTILKQVKESNGRIILFIDEIHQIVGLGRNSSSGAMDIANILKPMLARGEIKVIGATTLKEYREYIEKDGALERRFQKILINEPSSQEALTIMRGLKTRWELFHNITIFDSALVAAVEMSTRYINERNLPDKAIDLIDEAAAKIKTEMSSEPVAIDSLKREIINLETEYAALKQDKENDNKQSKKEYLEKLKKQLDALKQKRDSLINEWKKEKADFENINKLKKEIEEFQTKLETYQSEGNYESASKILYSDIPRLKKELESAQQKYATSKHDLFKTEVSENEIAEVISQTTGIPLKKLLESEKDKLLHLGDEIKKRVKGQDEAIDAVVNTVIRGRVNINDPNKPIGSFIFLGSTGVGKTELAKSLAEVLFDNEKALIRFDMSEYMEKHSVAKLIGAPPGYIGYEQSGLLTEAVRRKPYSVLLFDEIEKAHPDVTNVLLQVLDDGTLKDSQGRVVNFKNTLIIMTSNLGSNFLLEGKKDLAIQSLKKHFRPEFINRIDEIVFFNVLEKDTVLSIINSLLAQLSKRLNKQNLFFNFDSNLTEFIYKSSFDQQFGARPIKRFIDHSVATLIAKYILQGKIKKGVGYNIAVVKDNITITQNNKS
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_CHLP8
Sequence: MLAKRIIPCLDVRDGRVVKGINFEGLRDAGSILEQARFYNNEMADELVFLDISASIESRRTTLEEVLKVSGEVFIPLTVGGGISSVERARDAFLHGADKVSVNTAAVNDPVLISRIAERFGSQAVVVAIDVKKVNGEYIVHTHSGKTPTQYEALEWAHRVQELGAGEILLTSMDRDGTQEGYDNEILKRISTSVHIPVIASGGAGNLEHLYEGFTKGHADAALAASIFHFRTYSIREAKEYLRDKGIAVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NP93A_ARATH
Sequence: MANDQEMSGWTDLLHSSSKLLEQAAPSSQFPPLQRNLDQLEALSKKLKAKTLRNEAPSQSIAATRLLAREGINAEQLARDLKSFELKTTFEDVFPAEATSVEEYLQQVHEMAMVSAIQEAQKDNVRSFNDYMMKVLEEDWRKEKRDFLQSLSRISMLPKTNMIDTSREAHAGQLVPVGSSPRVSSTPGKELVALANIPIHEKKAYVYGEVVKKLNTSRERGMPFRPAMCFKDAYDTLGAEVTRGKSVNMQKIWQLVQAITGEDSAVRQGVSKRMALAIGARHHLQHGHEKFIMDTIQTHPTQAALGGSVGNLQRIRAFLRIRLRDYGVLDFDSTDARRQPPVDTTWQQIYFCLRTGYYEEAREIARSTRSSQQFAPLLTEWITTDGMVAAESAAIASEECEKMLRMGDRLGRTAYDKKKLLLYTIISGSRRQIERILRDLSTLFNTIEDFLWFKLSCIRDVTGGSSSVVLNDGLAPYSLDDLQAYLNKFEPSYYTKNGKDPLVYPYVLLLSVQLLPAIMHLSKEAGDGGYNIDAVHIAISLVDHSVLSEGSGTGHKLSVMDSNAEASSMIRQYGSMFLHHGDLQMTVEYYAQAAATVGGGQLAWSGRSNVDQQRQRNLMLKQLLTEILLRERGIYFLLGARGSGEEGQLGRFFPDSRLRQQFLVEAAHQCQEAGLYDKSIELQKRVGAFSAALETINKCLSEAICSLARGRLDGESRTSGLILAGNDILETYKYYPEVSLQERERVMEQETILRELEAILSIHKLGRLGNHLDALREIAKLPFLHLDPRMPDATADVFQSASPYFQTCVPDLLKVALTCLDNVPDTDGSIRAMRSKIAGFLASNTHRNWPRDLYEKVARSF
What are the official names of this protein?
Nuclear pore complex protein NUP93A, Nucleoporin 93A.
What is the protein family that this protein belongs to?
Belongs to the nucleoporin interacting component (NIC) family.
What are the subcellular locations of this protein?
Nucleus envelope. Nucleus, nuclear pore complex.
Protein: FOLD_SYNFM
Sequence: MAAKLLKGAEVAKEIRAELKTEVEQLQSKHGVVPGLVTILVGENPASQSYVRAKQNTAHELGFHSVQDNQPADLEENRLLDLIDKYNKDPSIHGILVQLPLPKHINENRILLSIDPSKDVDAFHPVNVGKLMIGEPDYLPCTPAGIQELLVRSGTQVSGAEVTIVGRSNIVGKPIAMMLVQKANGANATITVCHTRTKDVASHTRRADILIVAAGVAEYVKGNMIKPGAVVIDVGVNEVGKTADGKRILKGDVAFDEAVEVASAITPVPGGVGPMTITMLMKNTVRACKVHNKIA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: TTI1_MOUSE
Sequence: MAVFDTPEEAFGVLRPVCVQLTKTQTVENVEHLQTQLQAISDTALQELQQYILFPLRFALKTPGPKRERLVQSVVECLTFVLSSTCVREQELLQELFSELSACLYSPSSQKPAALSEELKLAVIQGLSTLMHSAYRDIILTFYEPSILPRLGFAVSLLLGLAEQEKSKQIKIAALQCLQVLLLQCDCQDHPRPLDELEQQQLGDLLASFLPGISTALTRIITGDFKQGHSIVVSSLKVFYKTVGFIMADEQLTRIPKAQAKPVVEHRVAALMIHREADWVKSTGDKLAIFIKKIIDCVSVHPHWKVRLELVEFVEILLLKCTQSLVESTGPLLKVLVGLVNDESPEVQARCSTVLRRLADQKVVVGSRALADILSESLHSLATSLPRLMNTQDDQGKFSTLSLLLGYLKLLGPKVHVILNSVAHVQRLSRALIQVLELEVTDVKMVEERRWNSDNLSASAEVSAARPWSRVQRRYFRCFTDERVFLLLRKICQLLGYYGDLYLLVDHFMELYHTSVVYRKQAAMILNELVVGAAGLDVEDIHNKCPSMGPEELREIVKSILEEYTSQENWYLITCFEAEEGEEVMMKQQGFQAVTSGVHTCQVVSFPALSKPSPTICSMNSNIWQICIQLEGIGQFAYALGKDFRLLLMSALYPILEKAGDPTLLISQVATSTMVDICHACGYNSVQHLINQNSDYLVNGISLNLRHLALHPHAPKVLEAMLRNADASLLPLVADVVQDVLATLDQFYDKRAASFVSVLHALLAALAHWFPDSGSTGQLQQRSLEEEGRQLPAAGEASTTAEDIEQFVLSYLQEKDVAEGNVSDLEAEEEVQSAPPKVDENDTLPDVEPPLPTHIQIAKDVMERCIHLSADKNLKIRLKVLDVLGLCVEVLQTHKNQLLPLAHRAWPSLVHRLTSDDPLAVLRAFKVLQTLGSRCGDFLRSRFCKDVLPKLTSSLITQAPISARAGPVYSHTLAFKLQLAVLQGLGPLCENLDLGEGDLNKVADACVIYLSTKQPVKLQEAARSVFLHLMRVDPDSTWLLLHELYCPVQQFTAPHPSLHPVQLQGATQPQNPYATNVCHLLLQLQ
What is the function of this protein?
Regulator of the DNA damage response (DDR).  Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins.  The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC).  Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.  Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals (By similarity).
What are the official names of this protein?
TELO2-interacting protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the tti1 family.
What are the subcellular locations of this protein?
Cytoplasm.