PharMolix/UniProtQA huggingface dataset:
Protein: TFDE1_CUPPJ
Sequence: MLSDGVEITSRSGGRFGAYLGKPTTDSAPIVVIAQEIFGITPFIRETVEWLVGAGFGCVCPDLYWRQAPNIELDANVPSEREQALALFRDFDMEAGVNDLSCAIEYARALPFSNGRVAVVGYCLGGALAFDVAARSLADCSIGYYGVGLEKKVSLVPAITRPAMFHMGTKDHYVTEEARSILEEHFGRNKNLSLHWYPVGHSFARSSSPNFDQAATTVANARTLELLAMLKDPS
What is the function of this protein?
Ring cleavage of cyclic ester dienelactone to produce maleylacetate.
What are the official names of this protein?
Carboxymethylenebutenolidase 1, Carboxymethylenebutenolidase I, Dienelactone hydrolase I, DLH I.
What is the protein family that this protein belongs to?
Belongs to the dienelactone hydrolase family.
Protein: EPO_SPAJD
Sequence: MGVPDCLALPLLVTFLLLSLGLPVLGAPPRLICDSRVLERYILEAKEAENITMGCAEGPRFNENFTVPDTKVNFYAWKTMGVEEQAVEVWQGLSLLFEAILRAQAVLANSSQPSEMLQLHVDKAISGLRSLTSLLRALGAQKEAISPPDTTQVIPLRRFTVDTFCKLFRIYSNFLRGKLKLYTGEACRRGDR
What is the function of this protein?
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass.  Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
What are the official names of this protein?
Erythropoietin.
What is the protein family that this protein belongs to?
Belongs to the EPO/TPO family.
What are the subcellular locations of this protein?
Secreted.
Protein: MDTC_ECO27
Sequence: MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAISNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRARLPELQSTIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRGERSETAQQIIDRLRKKLAKEPGANLFLMAVQDIRVGGRQANASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQEDNGAEMNLIYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQAVTE
What is the function of this protein?
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtC, Multidrug transporter MdtC.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VG28_EHV2
Sequence: MTTSPTTISTTTAATTTTTTPGKGTDSPMVYIEAMLFSMLVLILLIIVCAGYVHVKNLYYRSRYGVTAIYQQVEAECRGVSLGRSVDEPPYQSIYMPD
What are the official names of this protein?
Uncharacterized gene 28 protein.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: ACDH_PSET1
Sequence: MKKIKCALIGSGNIGTDLLYKLKRSEILEPVWMVGIDPDSEGLARARELGIKTTADGIDGLIPHIEADEIKIAFDATSAYVHGENSAKVNAKGVLMIDLTPAAIGPFCVPPVNLNQLNADIKNVNMVTCGGQATIPMVAAVSRVQPVEYGEIVATVSSKSVGPGTRQNIDEFTRTTSGAVEQIGGAKKGKAIIIINPAEPPLLMRDTIHCLTETEPDQAAITASVHEMIAEVQKYVPGYKLKNGPVFDGRKVSIFLEVEGLGDYLPKYAGNLDIMTASAARTAEMFALQMLGQSPSDSQS
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: PSBH_EUGGR
Sequence: MTTISKNKTSNSKGKTTTLGTILKPLNSKYGKVLPGWGTAGIMLIFMTLFAIFLTIILEIYNSSVILDIK
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SRE38_CAEEL
Sequence: MIKFNSTNKTYWLPIYIMNDTSFQSGMYLYLLLTEILLYVGTGVIICKTVRTFLKIRLFHRNMNIMTALFLCQWFEAIAAKLLIIPYQIGVIRFSDYNKPYVSWWTDNEQEIIVLPEPTANSNALVISGFLIWHYAYTMIFGILNLGIERIFATVMLKDYENKPRLYIPVFLITSTHLITLTFSYFVLTNRTGFYLGTSPCFLNSALVVMTFLAVWKVNKHRHEKLEGSGPGCDYTLSQQFQVRENYRALKLAKNLVIVVLCAISVPCALLICLVIGAIPSFRMIFIHIMENFIYLNPVIICSTLMFSAPAWRAEYLKLIPGYKKIKSTRVFVVRPKPQTTHRASSTVVHDEGQMYFEQLNNSWK
What are the official names of this protein?
Serpentine receptor class epsilon-38, Protein sre-38.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein sre family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SRRT_DROYA
Sequence: MADSDDEYDRKRRDKFRGERSDSYRTERRDDRRAVGGSTGARDEWAERNPFRGGASAGGGGARHRPDYSDYRGPGARPRYGSPGRDLPPAKRMRPDWGDGDVRANPRFGGYDPYLMQAWNDHYQSMHSAFSHAGHAPPVRESIGGGGSDTLTQPAMLNLKQFLDTQDENISDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVKRSEEQRGFLQRRTDVFVELLENGTIGSVKVDSSQGDALIRVLDTCVIKLEGGTDEDLKVLDEKPKDLVVYERKTEPMESVKAMEKAISSPKEEKIREEDPLPAVVSPQQKTARSVNSDEENWNDEDAVTKKDLGEHSKDTDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKAEAEKDRQEAAKAKQEPESSKLEELVGKEITEPKELDSKINTVENDDTLKSPEMTPNPIKRTDNGNGNKVEDEEKPSVDENKVVETETIDLDKIKDGQPRALHRTSSIFLRNLAPSITRAEIEAVCNRFTGYLRVAIADPLVERRWYRRGWITFMRDVNIKEICWGLNNQRLRDCEMGAIVNRDLSRRVRPANGLTAHKQVVRSDIKLCAKIALNLDERFRLWAEVPTDDSNSARADESSENGSGSTYGFNSKNPVLQNITDYLIEEASAEEDELLGLTGENKDTEGEAIERDEQLISVLDRLVLYLRIVHSVDYYNHCEYPYEDEMPNRCGIIHARGPAPVRVTNNDVQEYIKTYESKLQQFLTKTVLLSDEEIKDLGAKDAETEVEKFVQANTQELAKDKWLCPLSGKKFKGPEFIRKHIFNKHDEKVDEVRKEVQYFNNYLRDPKRPQLPEHPGTSKRPESESARGGGGGYRPPMYPPFSAMPYGFGPPMMGGGRGGRNFPPARRELPLEHQRRLIGYHDLDAPANSDMFD
What is the function of this protein?
Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi).  Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha (By similarity).
What are the official names of this protein?
Serrate RNA effector molecule homolog, Arsenite-resistance protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the ARS2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVB_BARHE
Sequence: MHKDEDQRLLGAVPLPNDPDRSLRPQVLDDFIGQEAARANLKIFIEAAKARQEALDHVLFVGPPGLGKTTLSQIMAKELGVNFRSTSGPVIAKAGDLAALLTNLEERDVLFIDEIHRLSPAIEEILYPAMEDYQLDLIIGEGPAARSVKIDLAKFTLVAATTRLGLLTTPLRDRFGIPIRLNFYTIEELEYIVQRNARLFSVQISEDGAHEIARRARGTPRIAGRLLRRVCDFALVKRAKKIDRKIADEALSRLEVDHLGLDPLDRRYLLLIAQTFLGGPVGIETIAAALSEPRDAIEDIIEPYLLQQGFIQRTARGRILHQKAWSHLGLCAPASTQKHPQLFDMPDNASRQTVLWDEADD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: TX322_LYCSI
Sequence: MKFVLLFGVFLVTLFSYSSAEMLDDFDQADEDELLSLIEKEEARAKECTPRFYDCSHDRHSCCRSELFKDVCTCFYPEGGDNEVCTCQQPKHLKYMEKAADKAKKFGGKIKRWFG
What are the official names of this protein?
U3-lycotoxin-Ls1h, Toxin-like structure LSTX-B22.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: COBQ_BRASB
Sequence: MPARAIMFQGTGSDVGKSLIVAGLARALTLRGLKVAPFKPQNMSNNAAVTADGGEIGRAQALQARAARRPMTVHMNPVLLKPQSEIGSQVVVQGRVIGNAKASAYQAMKPQLMKAVLDSFHHLIADTDIALVEGAGSASEINLRAGDIANMGFAQATQIPVVLIGDIDRGGVIASLVGTQAVLAPDDAALIAGFLVNKFRGDPALFASGMSEIATRTRWTSLGLIPHFADARRLPAEDALGLPGGGVWSRDRPKIAVLAYPRISNFDEFDPLRLEDGVDLQFLRPGTPIPGDAAVVILPGSKATIADLAALREAGWDIDLQAHLRRGGRVLGICGGYQMLGRMISDPDGHEGAPGAVAGLGLLDIETTLTGDKALRDVEGRLTQDEAPFRGYEMHIGRTDGPAAQHPFLVFSDGRRDGAVAAGGQIAGCYVHGLFADDHLRAHWLRGLGTTASGQSYDADVDATLDALAAHLERYIDIDRILDLARVPRAIT
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: SECB_CROS8
Sequence: MSEQNNTEMNFQLLRIYTKDISFEAPNAPHVFQKDWQPEVKLDLDTASSQLADDVYEVVLRVTVTASLGEETAFLCEVQQAGIFNISGIEGTQMAHCLGAYCPNSLFPYARECITNLVSRGTFPQLNLAPVNFDALFMNYLQQQAAEGAPNHQDA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRP28_ASPCL
Sequence: MDGFISNGPAEAPATMPPPEPFERPPTPPPPPPEDSAAPPPPPDTSAPPPPPEDAIPAPPLEKKKKAGWGAKRAAATPLSVEELVRKKREADAAAAKPKFLSRAERERLALEKRAKEVDADRRLKTERTANGADSSSAQSTPVYPERPNSDKRVIPTGPRAMRNTEAPARSGPAATRNKNYDMTPPAPPKPMSFSLTDSKGDSKRQAEEDETVAQVALIKQRYMGEEKTSNFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQHRHEANFYGRGRLAGFGDDVADSLAKKYARALEDRDQEAGSIRAREMLEMEKRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGSVPNPMRSWEESGLPKRLLELVDRVGYKEPTPIQRAAIPIALQSRDLIGVAVTGSGKTASFLLPLLVYIAELPRIDEFEWRKNDGPYAIVLAPTRELAQQIEIEAKKFTQPLGFNVVSIVGGHSLEEQAYSLRNGAEIIIATPGRLVDCIERRILVLSQCCYIIMDEADRMIDLGFEEPVNKILDALPVTNEKPDSDEAENSAAMRSHRYRQTMMYTATMPSAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVELIAGEDKRKKRLADILSSGEFRPPIIVFVNIKRNCDAIAREIKHMGFSSVTLHGSKTQDQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVVNFNMATSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLMKSPISRVPEELRKHEAAQSKPTRGYAKKSDESSGFRDKGAWQ
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA splicing.  May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site.  May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing ATP-dependent RNA helicase prp28.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PG053_VARV
Sequence: MAETKEFKTLYNLFIDSYLQKLAQHSIPTNVTCAIHIGEVIGQFKNCALRITNKCMSNTRLSFTLMVESFIEVISLLPEKDRRAIAEEIGIDLNDVPSAVSKLEKNCNAYAEVNNIIDIQKLNIGECSAPPGQHMLLQIVNTGSAGANCGLQTILKSLNKIYVPPIIENRLPYYDPWFLVGVAIILVIFTVAICSIRRNLALKYRYGTFLYV
What is the function of this protein?
Component of the entry fusion complex (EFC), which consists of 11 proteins.  During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation.
What are the official names of this protein?
EFC-associated protein OPG053, Protein F9.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG053 family.
Protein: T2R10_PANPA
Sequence: MLRVVEGIFIFVVISESVFGVLGNGFIGLVNCIDCAKNKLSTIGFILTGLAISRIFLIWIIITDGFIQIFSPNIYASSNLIEYISYFWVIGNQSSMWFATSLSIFYFLKIANFSNYIFLWLKSRTNMVLPFMIVFLLISSLLNFAYIAKILNDYKMKNDTVWDLNMYKSEYFIKQILLNLGVIFFFTLSLITCVLLIISLWRHNRQMQSNVTGLRDSNTEAHVKAMKVLISFIILFILYFIGMAIEISYFTVRENKLLLMFGMTTTAIYPWGHSFILILGNSKLKQASLRVLQQLKCCEKRKNLRVT
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 10, T2R10.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SEPF_FRACC
Sequence: MGLGRRAMVYLGLAEEDEDYLDDDYDDGRAVGRDDRRAMHEPVPMDRTVRRIDAREEPVAMPRRPPVEPLRPAGPVPMRRVAAVEESHPYRITTLQPRSYNEARQIGEEFRDGTPVIMNLTDMDDADAKRLVDFAAGLIFGLRGDLEKVTNKVFLLSPHNVEVTETDKRRIREGGFYNQS
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: ROG1_YEAST
Sequence: MSLTPTNEILFHYKSSVKVGELERYVITYHLYDGEEIPPDLNLNSLWLKVRNMNPLSYRAAYLMGPFMLYCDVKTAQYHHSQKIVASVDYPKFEPNVQTQQDFVAELSVHNIRQKYVWIADVMSQILFTTNTNVTYEVTIGTSKESVENPHDLPSHLGSYSPKLTVNRLTTLDLWNLPVQITTPQKKKHLVVLTHGLHSNVSTDLVYIMEQIYKAQKNYPHEQIVVKGYRGNVCQTEKGVKYLGTRLAEYIIQDLYDESIRKISFVGHSLGGLIQAFAIAYIYEVYPWFFKKVNPINFITLASPLLGIVTDNPAYIKVLLSFGVIGKTGQDLGLENDVEVGKPLLYLLSGLPLIEILRRFKRRTVYANAINDGIVPLYTASLLFLDYNDILEQLQKLKENSKKSPLINDASTPVNQDFFNKTFISPLTKMLSILAPQKFPTENGSEIPKVSFFESASSILLPPLPERAYIMDPDSRDPVIIHDKIYNEDDIPQSEFDIEDGFFGKKNILLQAFFAGKKERAKYRNLEETIARRWHEGMAWRKVVVALKPDAHNNIIVRRKFANAYGWPVIDHLIDVHFNGDDDDDNDENDDINSTQVVEPIQSVTEGKKKYRKAENIPQEYGWLNKVETNGVFDEGPTGMISTVGEIVEALAKRGFSAVIDRRNASEDPNDEVLRFEEMNSDLVQ
What are the official names of this protein?
Putative lipase ROG1, Revertant of glycogen synthase kinase mutation protein 1.
What is the protein family that this protein belongs to?
Belongs to the putative lipase ROG1 family.
Protein: NUOA_BACC1
Sequence: MASVYENSYMIVLIFLLLGILLPVVALTLGRMLRPSKPSAAKATTYESGIEPFHDANIRFHARYYIFALLFVIFDVETLFLYPWAVAYDKLGLFALIEMFIFVVMLLVGLAYAWKKKVLQWL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISCS_HAES1
Sequence: MKLPIYLDYAATCPVDERVVKKMMEFLSIDGNFGNPASRSHKFGWQAEEAVDVARNHIADLIGADSREIVFTSGATEADNLALKGVMRFYQTKGKHLITCKTEHKAILDTCRQLEREGFEVTYLDPKSDGLIDLEELKSVIRDDTVLVSIMHANNEIGVVQDIAKIGEICRERKVLFHTDATQSVGKLPINLSELKVDLLSMSSHKLYGPKGIGALYVCRKPRVRLEAIIHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMPRLTALRDRLYNGLKDIEETYVNGSMEQRLGNNLNISFNYVEGESLMMALRDIAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFTVGRYTTAEEIDYAIGLVKSAVEKLRDLSPLWDMFKEGIDLNSIEWTHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_ROSDO
Sequence: MSRKNYVFTSESVSEGHPDKLCDRISDAVLDAFIAEEPEARVAAETFATTNRVVIGGEVGLSDKDKLHDYMDRIEAIARACIKDIGYEQDKFHHATCQVTNLLHEQSAHIAQGVDAAKGKDEGAGDQGIMFGYASNETPELMPAPIHYAHAVLRRLAEVRKDGTEPTLRPDAKSQLSVRYEDGKPVGVTSVVLSTQHADESQTSDDIRAIVEPYIREVLPDGWITGDTEWWVNPTGTFVIGGPDGDAGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYVARYLAKNVVAAGLANKCTIQLSYAIGVSKPLSIYCDTFGTGEVDEEEIERAIGKVMDLTPRGIREHLHLNKPIYERTAAYGHFGRAPDADGGFSWEKTDLADVLKAAL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_STRTD
Sequence: MTYVDTLGQQAKVASRQIAKLSTAAKNDLLNQVAKALVAESDYIITENAKDIANASENGISKIMQDRLLLTEDRIAGIAEGVRQVADLQDPIGQVVRGYTNLDGLKIVQKRVPMGVIAMIFESRPNVSIDAFSLAFKTNNAIILRGGRDAINSNKALVTVARKALKNAGITADAVQFVEDTSHEVAEELMVATKYVDLLIPRGGARLIQTVKEKAKVPVIETGVGNCHIYVDKYANLDMATQIVINAKTQRPSVCNAAESLVVHADIVEEFLPNLEKAISKIQSVEFRADERALKLMEKAVPASPEDFATEFLDYIMSVKVVDSLDEAINWINTYTTSHSEAIVTQDISRAEQFQDDVDAAAVYVNASTRFTDGFVFGLGAEIGISTQKMHARGPMGLEALTSTKFYINGQGQIRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSHC_BACC1
Sequence: MEIKEISVPQQGVVADYMNGKKEIQSCFDYMLTEDAFKQRVQDLREREFFRQDLVAHLLEYNTKLQAGEATIQNVKALGDEDTYVVIAGQQAGLLTGPLYTIHKIISVLQLAKEKEESLGVKVVPVFWIAGEDHDMDEINHTFVTKNKKIKKTIFHDRNPKKASASESELSLEDCRKWIEEIFKTYPETNFTKDVLQFIDDSLGESNTYVDFFGHLIMKMFINSGLILVDSHHPELRKLEVPFFKQIISKYKEVQEGLHNQQEVIKELGYKPIIETKSNAVHIFMEIDNERVLLEDNQGKFVGKDGTYSFSYEELIEEMERSPERFSNNVVTRPLMQEYVFPTLAFIGGPGELAYWSELQQVFHTIGFRMPPVVPRITITYIERDIATDLHDLQLQESDPFLNNVDKLRENWLSNQIEEPIDERFVEAKKEIIDIHKSLQQFVKKIDPGLSSFAGKNEFKINEQIELLERMLKRNVEKKHEVELNKFRRIQFAIRPLGAPQERVWNVCYYLNQFGLDFVDRVMENSFSWNGKHHVIKL
What is the function of this protein?
Involved in bacillithiol (BSH) biosynthesis.  May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.
What are the official names of this protein?
Putative cysteine ligase BshC.
What is the protein family that this protein belongs to?
Belongs to the BshC family.
Protein: BIOD_SULNB
Sequence: MSSLFITATGTNVGKTHTTLKLLDALAAKGRSVGVFKPIETGVLDSAPDATILLESCRKVNRNFEGLKTEDITAYTFPLPAAPFCADTNHKIRIDRILEKYHQLSQLCDILLVEGAGGLMVPVTRDFFMIDLIKELQTRVLLVTPGRLGCINDTLLSMEALKSRNIAFDWCINLYEDAESFTEVTQPFYDAVFPAWWSDKEGMEKFARSL
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTLD_YERPY
Sequence: MKALHFGAGNIGRGFIGKLLADAGAQLTFADVNQPLLDALNKRKRYQVNVVGEQARVEEVKNVSAVNSGSPEVVALIAEADIVTTAVGPQILARIAATVAQGLITRHQQGNTRPLNIIACENMVRGTSQLKQHVFAALSEDEQIWVEQHVGFVDSAVDRIVPPSEAGSTDILAVTVETFSEWIVDGTQFKGQPPEIVGMELTDNLMAFVERKLFTLNTGHAITAYLGQLAGHQTIRDAILDPAVRQTVKGAMEESGAVLIKRYAFDPQKHAAYINKILSRFENPYLHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYQLPHDSLVTGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQISGLPADSEVVEQAVSVYNAMQQKLAH
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: SYS_PYRCJ
Sequence: MSYSVLEALRKSPEEVRKVLLARRVDASLVDKFLALDAKWRQLKKEIDELRHLYNQLSREGAKAPPERRREISEKARELAAKLEKVEEEVKELERQREELLYSFPNLIHESVPVCPEGVDSVPVRHWGTVKVSNAALQSLDPGVEYVVVEKEPVGHADMAEVVLQMADTLKAGEVAGSRFYYLFDDLVWLDFALAMYAMDQLAQKGFRPVIPPYMLKFDIIRRVLDFDTFKDAIYKIEGEDLYLIATAEHGIAAYLYKRELLEEELPQLYVGWSPCFRKEAGAGNRDLKGIFRVHIFHKVEQFVFSLPEESWKWHEEITRNTEELIRGLGLPYRVVNICAHDLGAPAAKKYDIEVWYPAQAKYRELASCSNVTDWQSYRLGIRVTRKGMKKEYVHTLNCTGLATTRTITAILENFQRDDGVVEIPKALRPYLEPIKAAPKEYIYPRRIKQQPPS
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.