PharMolix/UniProtQA huggingface dataset:
Protein: LOLA_PSEF5
Sequence: MRLIRMLLLPVLAVTTLSAHADPKDVARLTQLLEKSQTLTARFSQLTLDGSGTQLQETAGEMSLQRPGLFYWHTDAPQEQLMVSDGQKVSLWDPDLEQVTIKKLDQRLTQTPALLLSGDVSKISESFDITSKEAGGVMDFTLKPKTRDTLFDSLRLSFRNGMINDMQLIDSVGQRTNILFTGVKANEAIPASKFKFDIPKGADVIQE
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: BOLA3_BOVIN
Sequence: MAAWSPAAAVPLLRGTRRLPLLHWAQRMFASQTEAELKVTQILKEKFPRATAIKVTDISGGCGAMYEIKIESEEFKEKRTVQQHQMVNQALKEEIKGMHGLRIFTSVPKH
What is the function of this protein?
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins.  Probably acts together with NFU1.
What are the official names of this protein?
BolA-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the BolA/IbaG family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PSIE_SALAR
Sequence: MMSLSRSHLELIATILQNVLNLGLLTLGLILVLFLGKETVHLADALFVPEQASKYELVEGLVIYFLYFEFIALIVKYFKSGFHFPLRYFVYIGITAIVRLIIVDHKTPMDVLLYSAAILLLVITLWLCNSNRLRRE
What are the official names of this protein?
Protein PsiE.
What is the protein family that this protein belongs to?
Belongs to the PsiE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYHD_NPVPF
Sequence: MYTRYSYNPSLGRTYVYDNKYYKNLGAVIKNANRKKHFIEHELEEKTLDPLDRYLVAEDPFLGPGKNQKLTLFKEIRNVKPDTMKLVVNWSGKEFLRETWTRFMEDSFPIVNDQEVMDVFLVINMRPTRPNRCYKFLAQHALRCDPEYVPHEVIRIVEPSYVGSNNEYRVSLAKRGGGCPVMNLHSEYTNSFEEFINRVIWENFYKPIVYVGTDSAEEEEILLEVSLVFKIKEFAPDAPLYNGPAY
What is the function of this protein?
Major component of the virus occlusion bodies, which are large proteinaceous structures (polyhedra), that protect the virus from the outside environment for extended periods until they are ingested by insect larvae.
What are the official names of this protein?
Polyhedrin, Major occlusion protein.
What is the protein family that this protein belongs to?
Belongs to the polyhedrin family.
Protein: EIF3M_SCHJA
Sequence: MSIAVFIDGTDAQQVTELKKFLKSYGAKVLDNTECSDANWPDELIKCIKFLNVCWKDESIAESDAKDVLTSVASMFIQLPPNKLIEAVPLFCEKLLDFSGDNIRRHKNKLFPLNLLFWGLNPKSHPRYEIFLTLIECAEKMGVLNEVITDPKKVASWLSECDCTVEECQKVWQKLYDAHIALGENRKAIEAMIYLLSTYNEVTAVNARQNAIKCIISVLQDPCLLSHDQLYALKPVQYLEGEPVHDFFKIFVSGDLNTFKNFLAKHPNFLSHNNLSEEACVHKLRLLTLMQLSENVNELSYHEAATQLGLKIEELEPFIIEAVRQRAVACKLDQVQKKILITGAFPRTFGRPQWINLHDTLVQWRSHLGTVQSSLSMMIQNESS
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit M, eIF3m.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit M family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMC5_PONAB
Sequence: MAPSLWKGLVGIGLFALAHAALSAAQHRSYMRLTEKEDESLPIDIVLQTLLAFAVTCYGIVHIAGEFKDMDATSELKNKTFDTLRNHPSFYVFNHRGRVLFRPSDTANSSNQDALSSNTSLKLRKLESLRR
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity).  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.  May be involved in Mg(2+) transport (By similarity).
What are the official names of this protein?
ER membrane protein complex subunit 5, Membrane magnesium transporter 1.
What is the protein family that this protein belongs to?
Belongs to the membrane magnesium transporter (TC 1.A.67) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: KAE1_ASPOR
Sequence: MIAIGLEGSANKLGVGIMLHPDNGNPPQVLANIRHTYVSPPGEGFLPKDTARHHRAWVVKLVKKALKEAHVSVQDVDCICFTKGPGMGAPLQSVAVAARMLSLLWGKELVGVNHCVGHIEMGRLITGSTNPVVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLHISNDPAPGYNIEQLAKKGKQLVDLPYTVKGMDCSFSGILAAVDGLATTYGLGGEGKDDETDTPIPDADGNGKPTRADLCFSLQETIFSMLVETTERAMAHVGSKEVLIVGGVGCNERLQEMMGIMARDRGGSVHATDERFCIDNGIMIAQAGLLAYSTGFRTPLKDSTCTQRFRTDDVFVKWRD
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein kae1, tRNA threonylcarbamoyladenosine biosynthesis protein kae1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MSL1_MOUSE
Sequence: MTMRSAVFKAAAAPAGGNPEQRLDYERAAALGGPEDESGAAEAHFLPRHRKLKEPGPPLASSQGGSPSPSPAGCGGGKGRGLLLPAGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPVAAGAGCSPRPKYQAVLPIQTGSIVVAAAKEPTPWAGDKGGAAPPAATASDPAGPPPLPLPGPPPLAPTATAGTLAASEGRWKSIRKSPLGGGGGSGASSQAACLKQILLLQLDLIEQQQQQLQAKEKEIEELKSERDTLLARIERMERRMQLVKRDNEKERHKLLQGYEPEEREEAELSEKIKLERQPELCETSQALPSKPFSCGRSGKGHKRKTPFGNTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSISETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEMEDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDILENLDDSVFSKRHAKLELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLLITPFLPVVAFGRPLPKLAPQNFELPWLDERSRCRLEIQKKHTPHRTCRK
What is the function of this protein?
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:24913909).  Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub) (By similarity).  This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity).  In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:21217699).  Isoform 2, isoform 3, isoform 4 and isoform 5 can medite histone H4 acetylation at 'Lys-16' (H4K16ac) (PubMed:24913909).
What are the official names of this protein?
Male-specific lethal 1 homolog, MSL-1, Hampin, Male-specific lethal 1-like 1, MSL1-like 1, Male-specific lethal-1 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the msl-1 family.
What are the subcellular locations of this protein?
Nucleus. SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Nucleus speckle. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Nucleus speckle. SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Nucleus, nucleoplasm. SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleoplasm. SUBCELLULAR LOCATION: [Isoform 5]: Nucleus, nucleoplasm.
Protein: RL27_BURCM
Sequence: MAHKKAGGSSRNGRDSESKRLGVKVYGGQAINAGGIIVRQRGTRMHAGENVGMGKDHTLFALVDGHVKFATKGADKKHLVIVVPAAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PGK_THEON
Sequence: MFRLTDFTYHGKTVFLRADLNSPVKDGRIISDARFRAVLPTIQHLLDEGAKLVIGTHQSKPYKGDYITTEQHAEILSNLLGQEVEYVEDIFGKYARERIKTLKPGEAIILENLRFAAEDVKYKPLEECERTHFVRKLAPLLDYVVNDAFAAAHRSQPSLVGLARLKPMIMGFLMEKEVEALSRAYETNEKPRIYVLGGAKVDDSLRVAENVLRNGRADLILTGGLVGHVFTLAKGFHLGDANLEFMAKKGLLELVDWAENILDEFYPYVRTPVDFAVDYKGERVEVDLLSDEKWLFDKYPILDIGSRTIEKYRDVLMNARVIVANGPMGVFEREEFALGTVGVFRAIGESQAFSVVGGGHSIASIYQYNITGISHVSTGGGAMLSFFSGEKLPILEAFRISYERFKDKIERGPK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF2_SALAI
Sequence: MTDADFAEQLKDLDTTLRNIESVLDIDRLRADKARLEEAASAPDLWDDQARAQQVTSQLSYVNGEITKLTDLRSRLDDTQVLLELAEAESDPGVLTEVAAEITGLAKSIDEMEVRTLLSGEYDSREALVAIRAGAGGVDAADFAEMLLRMYLRWAERHGYPTEVYETSYAEEAGLKSATFTVKVPYAYGTLSVESGTHRLVRISPFDNQGRRQTSFAGVEVLPVVEQTDHIDIPENEMRTDVYRSSGPGGQSVNTTDSAVRITHIPTGIVVTCQNEKSQLQNKASALRVLQARLLERKRQEEQAKLQGLKTDAAGSWGDQMRSYVLHPYQMVKDLRTEQETGSPSSVFDGELDAFIEAGIRWRKQQQLSGDNV
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHAM_SALNS
Sequence: MFESKINPLWQSFILAVQEEVKPALGCTEPISLALAAAAAAAELDGTVERIDAWVSPNLMKNGMGVTVPGTGMVGLPIAAALGALGGDAKAGLEVLKDASAKAVADAKAMLAAGHVAVMLQEPCNDILFSRAKVYSGDSWACVTIVGDHTNIVRIETDKGVVFTQADNAQEEEKTSPLGVLSHTSLEEILAFVNAVPFDAIRFILDAARLNGALSQEGLRGSWGLHIGSTLAKQCDRGLLAKDLSTAILIRTSAASDARMGGATLPAMSNSGSGNQGITATVPVMVVAEHVGADDERLARALMLSHLSAIYIHHQLPRLSALCAATTAAMGAAAGMAWLIDGRYDTIAMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHNVEQSIANLCSLACRSMQQTDKQIIEIMASKAH
What are the official names of this protein?
UPF0597 protein YhaM.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: EBPL_MOUSE
Sequence: MGEHWALGPEAGSSLLLCSALLAVGCALGLRLGRGRSAVERWVLAWLCYDSLVHFVLEGAFVYLSIVGNVADSQGLIASLWKEYGKADTRWLYSDPTVVSLEILTVVLDGLLALVLIYAIVKEKYYRHFVQIVLCVCELYGCWMTFFPEWLVGSPSLNTSSWLYLWVYLVFFNGLWVLIPGLLLWQSWVELKKRDSQEANLAKKHK
What is the function of this protein?
Does not possess sterol isomerase activity and does not bind sigma ligands.
What are the official names of this protein?
Emopamil-binding protein-like, Emopamil-binding-related protein.
What is the protein family that this protein belongs to?
Belongs to the EBP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GCH4_XANCB
Sequence: MSATLPDIAVTEPSALHAPLRWVGMQDIAIPVRLDEAEPSGTVAARAQVQVDLPRPELKGIHMSRLYRLLDRHLEQPLSPAMLSQLLQAMIDSHADCGSRAARVSLAFEVMLRMPALRSEGLAGWRAYPVRIDAQSRAGRSEMRLQIDVLYASTCPCSAALSRQLLSKAFAQQHAGQTALRVEDVAQWLQRNGSYATPHSQRSVAQVRVDLVARVQSFDIRALVLLCESALATPVQAAVRRIDEQAFARLNGANLMYVEDAARRLRKELAERYASFHVAVRHFESLHAHDAVAETGSDADVFHMIAESHGQ
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: QRCA_DESVH
Sequence: MEDRQLTNADNENGRKCACGGAAPFFVGLVVALVFGWWAFPEMLYSQKEQPIRFSHKVHVNDAGMECKQCHSLREDGSFAGLPSTASCAECHSDVLGSDPEEARFVAEYVKSGKEVKWLVYQYQPDNVFFSHAAHSLDGCNQCHQFSERELCNLCHLDVADSDKAPTHYENKLTGYSKQTMKMWQCERCHANENHLGVTNSSNACFVCHK
What is the function of this protein?
Component of the respiratory Qrc complex, that catalyzes the reduction of the menaquinone pool using electrons transferred from the reduced periplasmic cytochrome c3, and which is probably involved in sulfate respiration.  Is likely essential for growth on H(2) or formate since the periplasmic hydrogenases and/or formate dehydrogenases act as primary electron donors for the Qrc complex.
What are the official names of this protein?
Menaquinone reductase, multiheme cytochrome c subunit, Quinone reductase complex subunit A, Type I cytochrome c3:menaquinone oxidoreductase subunit A.
What is the protein family that this protein belongs to?
Belongs to the multiheme cytochrome c family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: B4GT5_MOUSE
Sequence: MRARRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLFMVQAQGILLRDNVRTIGAQVYEQVVRSAYAKRNSSLNDSDYPLDLNHSEAFPPTTTFLPEDFTYFANHPCPERLPSMKGPIDINMSEIAMDDIHELFSRDPAIKLGGHWKPADCVPRWKVAILIPFRNRHEHLPVLLRHLLPMLQRQRLQFAFYVIEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGEVQFLGRYALLRKSKERQGLDGLNNLNYSANVTYDALYKNITVNLTPELAQVTEY
What is the function of this protein?
Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:21057870, PubMed:23882130, PubMed:30114188).  LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (PubMed:30114188).  Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (PubMed:29415997).  Essential for extraembryonic development during early embryogenesis (PubMed:20574042, PubMed:21057870).
What are the official names of this protein?
Beta-1,4-galactosyltransferase 5, Beta-1,4-GalTase 5, Beta4Gal-T5, b4Gal-T5, Beta-1,4-GalT II, Glucosylceramide beta-1,4-galactosyltransferase, Lactosylceramide synthase, LacCer synthase, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 7 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Golgi apparatus. Note=Trans cisternae of Golgi stack.
Protein: AMPP2_METAQ
Sequence: MDYDLVMEDEFDALCLDVRRDHDSASKTKYPAKLHARKVVKELGVDDGLIYLPGQPDISLENSDQPRLFRQRRYFFYITGADFEDCAATYEVKHDKLTLWVPYVEPRQVLWFGSKPSAAECKRRYDVDEVRYTTQLSSFLRRFAAQPEPPVVYILHPDQAPDLGHGSQSQLRLDSSLLLPAMDRARVVKSDYEVAMVRRANDISSAAHRRVAERILRLTNEREIEAIIQAVCIANGSRSQAYPIIAGSGANGATLHYGANNAPLGGKQCVVIDAGCEWNCYASDITRTLPLSGSWTPKAAAIHAIVQRMQQECIAKVGPGTAWRDIHLHAASLGMEGLLGLGILKGRREDVARAGTVAAFFPHGLGHHVGLEVHDVSGTLALSAAEGHGTQLDFGKRAMVTPSMLADMTRSASSPDAAGVQERKTQLLLPNMIVTVEPGIYFCREYLEGYFRSDPAHADFIDWDLLEEYYDVGGVRIEDCILVTEDGYENLTVAPKGDELLDVINKGEK
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase MAC_04092, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: ERA_ECO5E
Sequence: MSIDKSYCGFIAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIHTEGAYQAIYVDTPGLHMEEKRAINRLMNKAASSSIGDVELVIFVVEGTRWTPDDEMVLNKLREGKAPVILAVNKVDNVQEKADLLPHLQFLASQMNFLDIVPISAETGLNVATIAAIVRKHLPEATHHFPEDYITDRSQRFMASEIIREKLMRFLGAELPYSVTVEIERFVSNERGGYDINGLILVEREGQKKMVIGNKGAKIKTIGIEARKDMQEMFEAPVHLELWVKVKSGWADDERALRSLGYVDDL
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: NDHM_PROMA
Sequence: MTDPLLKCTTRHIRIFTAITQNNNLIEDSDHLTMDLDPDNEFLWENQAIEKVQNRFSELVESQVGQELSDYVLRKIGSDLESYIRQMLQAGEVSYNPDSRVLNYSMGLPRTPELL
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit M, NAD(P)H dehydrogenase I subunit M, NDH-1 subunit M, NDH-M.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhM subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DAPB_BURTA
Sequence: MSSMKIAIAGASGRMGRMLIEAVLAAPDATLVGALDRTGSPQLGQDAGAFLGKQTGVALTDDIERVCAEADYLIDFTLPEGTLVHLDAALRHDVKLVIGTTGFSEPQKAQLRAAGEKIALVFSANMSVGVNVTMKLLEFAAKQFAQGYDIEIIEAHHRHKVDAPSGTALMMGETIAAATGRSLDDCAVYGRHGVTGERDPSTIGFSAIRGGDIVGDHTVLFAGIGERIEITHKSASRVSYAQGALRAARFLAGRDAGFFDMQDVLGLR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_MOUSE
Sequence: MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).
What are the official names of this protein?
60S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITM2C_PONAB
Sequence: MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPAREEQLPQHRSKRGSSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV
What is the function of this protein?
Negative regulator of amyloid-beta peptide production.  May inhibit the processing of APP by blocking its access to alpha- and beta-secretase.  Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor.  May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
What are the official names of this protein?
Integral membrane protein 2C.
What is the protein family that this protein belongs to?
Belongs to the ITM2 family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass type II membrane protein. Cell membrane; Single- pass type II membrane protein.
Protein: STHA_ECO55
Sequence: MPHSYDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYQNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNARFVDEHTLALDCPDGSVETLTAEKFVIACGSRPYHPTDVDFTHPRIYDSDSILSMHHEPRHVLIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALQNIGLETDSRGQLKVNSMYQTAQPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOA7_RHOJR
Sequence: MTRLYIQDVTLRDGMHAIRHRLAPAQLRTIAAALDAAGVDAIEVSHGDGLAGSSLTYGPGSNTDWEWITAAADVVTNAKLTTLLLPGIGTIAELEHAHTLGVRSVRVATHATEADIAVQHISRARELGMDVSGFLMMSHMAAPAELARQAKLMEQAGAHCVYVTDSGGRLTMSDVRDRVRAYRDVLDEATQIGIHAHENLSLSVANSVVAVEEGVTRVDASLAGQGAGAGNCPIEAFIAVATLQGWEHGCDLFALQDSADDLVRPLQDRPVQVDRETLTLGYAGVYSSFLRHAERAAIEYGLDTRRILLEVGKRELVGGQEDMIVDVALDLLSSHA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 7, HOA 7, 4-hydroxy-2-keto-pentanoic acid aldolase 7, 4-hydroxy-2-oxopentanoate aldolase 7.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: ATPE_STRE4
Sequence: MTQMTVQVVTPDGIKYDHHAKFISVTTPDGEMGILPNHINVIAPLQVHEMKIRRVSEDDRVDWVAINGGIIEIKDNVVTIVADSAERDRDIDVSRAERAKLRAERDIAEAETTHDIDEVRRAKVALRRALNRINVSKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PTHP_ENTFA
Sequence: MEKKEFHIVAETGIHARPATLLVQTASKFNSDINLEYKGKSVNLKSIMGVMSLGVGQGSDVTITVDGADEAEGMAAIVETLQKEGLAE
What is the function of this protein?
P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes.  Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources.  P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity (By similarity).
What are the official names of this protein?
Phosphocarrier protein HPr, Histidine-containing protein.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRR_STRTD
Sequence: MKKKEIVDDVTMKRAITRITYEIIERNKNLDKIVLAGIKTRGVYIAQRIQERLKQLENLDVPLIELDTKAYRDDVKSEQDTSLILIEIDGTDVILVDDVLYTGRTIRAAIDNIVSHGRPARVGLAVLVDRGHRELPIRADYVGKNIPTSQSEEIEVLVTEVDGKDSVNIIDPN
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.