PharMolix/UniProtQA huggingface dataset:
Protein: Y2325_MYCTO
Sequence: MTTTSAPARNGTRRPSRPIVLLIPVPGSSVIHDLWAGTKLLVVFGISVLLTFYPGWVTIGMMAALVLAAARIAHIPRGALPSVPRWLWIVLAIGFLTAALAGGTPVVAVGGVQLGLGGALHFLRITALSVVLLALGAMVSWTTNVAEISPAVATLGRPFRVLRIPVDEWAVALALALRAFPMLIDEFQVLYAARRLRPKRMPPSRKARRQRHARELIDLLAAAITVTLRRADEMGDAITARGGTGQLSAHPGRPKLADWVTLAITAMASGTAVAIESLILHS
What are the official names of this protein?
Uncharacterized protein MT2387.
What is the protein family that this protein belongs to?
Belongs to the CbiQ family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EBPL_HUMAN
Sequence: MGAEWELGAEAGGSLLLCAALLAAGCALGLRLGRGQGAADRGALIWLCYDALVHFALEGPFVYLSLVGNVANSDGLIASLWKEYGKADARWVYFDPTIVSVEILTVALDGSLALFLIYAIVKEKYYRHFLQITLCVCELYGCWMTFLPEWLTRSPNLNTSNWLYCWLYLFFFNGVWVLIPGLLLWQSWLELKKMHQKETSSVKKFQ
What is the function of this protein?
Does not possess sterol isomerase activity and does not bind sigma ligands.
What are the official names of this protein?
Emopamil-binding protein-like, Emopamil-binding-related protein.
What is the protein family that this protein belongs to?
Belongs to the EBP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL6_SHESM
Sequence: MSRVAKAPVSIPAGVEVTLNEQTLTVKGAKGSLTRVINNAVNVVIEDGVIKFLPVEGAVGAWAQAGTTRALVNNMVVGVSQGFERKLKLVGVGYRAKLVGADIDLTLGFSHPLVHKLPAGVTAECPSQTDIVLRGVDKQLIGQVAAEIRGYRPPEPYKGKGVRYDDEEVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: YRGK_CAEEL
Sequence: MEILNQFSQFSPNMEAQGASSIPQPSQDAHEKARQQAENQETAKNGMISQILDQAAMQRLSNLAVAKPEKAQMVEAALINMARRGQLSGKMTDDGLKALMERVSAQTQKATSVKFDRRRNELDSDEELDL
What are the official names of this protein?
Uncharacterized protein D2005.3.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: TRPA_ECOL6
Sequence: MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAECEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKAFVQPMKAATRS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: JIP5_LACBS
Sequence: MPEIDVGSQIFDVVFHPTFATVYTGLLNGHVKAFAYNEQGKEQAAFSVRPSKRSCRGLSIKHDGTHLYAVGKAKALKYNFISGLIIRCSVIDTATAQISTRPGAHDSTINRVKYLMPWLISTGDDDGVIKLWDPRQQECVREYTQHFDYITDFLWLDDKKQLVATSGDGTLSVMDVRSKKPEPFAQSEDQDDELLSIVAIKGHSKIVVGTQLGILSIFNRSKGWGDCVDRVPGHPLSIDALCNLPPGLPNVDPTSTVLTGSSDGYVRAVQILPTKLLGVVADHGEWPIERIAVGGGWWVGSVGHEDLLRMTDLEGFFLDQSEDKELKGALGVTNENEQSDEDEEMDVLGNDAGHPEVDGSGSSSSGESSEDSEASDGETPQAKQRKRKIEQKPLDVDKPKGRNEIDVENAFFDEL
What are the official names of this protein?
WD repeat-containing protein JIP5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PHLD_BOVIN
Sequence: MSAFRFWSGLLMLLGFLCPRSSPCGISTHIEIGHRALEFLHLQDGSINYKELLLRHQDAYQAGSVFPDSFYPSICERGQFHDVSESTHWTPFLNASVHYIRKNYPLPWDEDTEKLVAFLFGITSHMVADVNWHSLGIEQGFLRTMAAIDFHNSYPEAHPAGDFGGDVLSQFEFKFNYLSRHWYVPAEDLLGIYRELYGRIVITKKAIVDCSYLQFLEMYAEMLAISKLYPTYSVKSPFLVEQFQEYFLGGLEDMAFWSTNIYHLTSYMLKNGTSNCNLPENPLFITCGGQQNNTHGSKVQKNGFHKNVTAALTKNIGKHINYTKRGVFFSVDSWTMDSLSFMYKSLERSIREMFIGSSQPLTHVSSPAASYYLSFPYTRLGWAMTSADLNQDGYGDLVVGAPGYSHPGRIHVGRVYLIYGNDLGLPRIDLDLDKEAHGILEGFQPSGRFGSAVAVLDFNVDGVPDLAVGAPSVGSEKLTYTGAVYVYFGSKQGQLSSSPNVTISCQDTYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGSSYSSREKLNVEAANWMVKGEEDFAWLGYSLHGVNVNNRTLLLAGSPTWKDTSSQGHLFRTRDEKQSPGRVYGYFPPICQSWFTISGDKAMGKLGTSLSSGHVMVNGTRTQVLLVGAPTQDVVSKVSFLTMTLHQGGSTRMYELTPDSQPSLLSTFSGNRRFSRFGGVLHLSDLDNDGLDEIIVAAPLRITDATAGLMGEEDGRVYVFNGKQITVGDVTGKCKSWVTPCPEEKAQYVLISPEAGSRFGSSVITVRSKEKNQVIIAAGRSSLGARLSGVLHIYRLGQD
What is the function of this protein?
This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.
What are the official names of this protein?
Phosphatidylinositol-glycan-specific phospholipase D, PI-G PLD, Glycoprotein phospholipase D, Glycosyl-phosphatidylinositol-specific phospholipase D, GPI-PLD, GPI-specific phospholipase D.
What is the protein family that this protein belongs to?
Belongs to the GPLD1 family.
What are the subcellular locations of this protein?
Secreted. Note=Associated with the High-Density Lipoproteins (HDL).
Protein: HTR1_HALS3
Sequence: MTIAWARRRYGVKLGLGYIATAGLLVGVGVTTNDVPSTIVAGIAGLLTLGSINAAETVASIKEIAAQTERVANGNLEQEVTSTRTDEFGSLADSIEQMRQSLRGRLNEMERTRADLEETQAEAETAREEAEQAKQEAQAAEREARELAATYQDTAKRYGETMEAAATGDLTQRVDVDTDHEAMETVGTAFNQMMDDLQATVRTVTTVADEIEAKTERMSETSADIEASAGDTVEAVSKIESQANDQRTELDSAADDVQQVSASAEEIAATIDDLASRSEDVATASDAARDSSKSALDEMSSIETEVDDAVGQVEQLRDQVAEITDIVDVITDIGEQTNMLALNASIEAARAGGNADGDGFSVVADEVKDLAEETQDRANEIAAVVEKVTAQTEDVTASIQQTRTRVESGSETVESTLRDIRTIADSIAEVSNSIDEIQRTTSEQAETVQSTATSVERVAGLSDDTTALASDAESAVIGQRESAEEIAASLEQFQNTAVEQLQSRVASFTVATEDSETAGGSVEQPVMRAGADGGGA
What is the function of this protein?
Transduces signals from the phototaxis receptor sensory rhodopsin I (SR-I) to the flagellar motor.  Responds to light changes through the variation of the level of methylation.
What are the official names of this protein?
Sensory rhodopsin I transducer, HTR-I, Methyl-accepting phototaxis protein I, MPP-I.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFTS_ECOLI
Sequence: MAEITASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAKKAGNVAADGVIKTKIDGNYGIILEVNCQTDFVAKDAGFQAFADKVLDAAVAGKITDVEVLKAQFEEERVALVAKIGENINIRRVAALEGDVLGSYQHGARIGVLVAAKGADEELVKHIAMHVAASKPEFIKPEDVSAEVVEKEYQVQLDIAMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKTVGQLLKEHNAEVTGFIRFEVGEGIEKVETDFAAEVAAMSKQS
What is the function of this protein?
(Microbial infection) Promotes the tRNase activity of CdiA-CT from E. coli strain NC101 (CdiA-CT-NC101); required in vivo and in vitro.  Probably loads charged tRNA onto EF-Tu, making more ternary GTP-EF-Tu-aa-tRNA complexes.  The guanine nucleotide exchange factor capacity of this protein does not seem to be needed as no GTP hydrolysis occurs during tRNA cleavage.  CdiA-CT is the toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system.  CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion (PubMed:28973472).  EF-Ts interacts with at least 2 different toxic CT domains, the 2 toxins are different and degrade tRNA at different positions (PubMed:28973472, PubMed:28223500).
What are the official names of this protein?
Elongation factor Ts, EF-Ts, Bacteriophage Q beta RNA-directed RNA polymerase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIHB_ECO24
Sequence: MEKRKIILDCDPGHDDAIAIMMAAKHPAIDLLGITIVAGNQTLDKTLINGLNVCQKLEINVPVYAGMPQPIMRQQIVADNIHGETGLDGPVFEPLTRQAESTHAVKYIIDTLMASDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGNFTPSAEFNIFADPEAARVVFTSGVPLVMMGLDLTNQTVCTPDVIARMERAGGPAGELFSDIMNFTLKTQFENYGLAGGPVHDATCIGYLINPDGIKTQEMYVEVDVNSGPCYGRTVCDELGVLGKPANTKVGITIDTDWFWGLVEECVRGYIKTH
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.  Has a clear preference for cytidine over uridine.  Strictly specific for ribonucleosides.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihB, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihB subfamily.
Protein: P5CR3_XENLA
Sequence: MAASPRVSLPVGCIGAGRMAQGILEGILHKGEITPQNVMVSAPTDRNLEKLKARGCCTSHDNRSVVSNCRVVFLATKPHIIPSVLQEIYPKVTADHLIISMAAGVTLETLEKNLPPGSKVIRMMPNLPCVLQEGAIVFSRGRCAGEVEADVFESLVRTCGLCVEVPQSCIDIHTGVSGSGVAYVYTFAEALADGAVKMGMPSALARQIVAQTLLGAGKMLLQSEEHPASLRADVCTPGGTTIFGLHELEKGGLRAAVMNAVEAATTRAMDMGRK
What is the function of this protein?
Enzyme that catalyzes the last step in proline biosynthesis.  Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs).  PYCRL is exclusively linked to the conversion of ornithine to proline.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase 3, P5C reductase 3, P5CR 3, Pyrroline-5-carboxylate reductase-like protein.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAEX_SHISS
Sequence: MSLFPVIVVFGLSFPPIFFELLLSLAIFWLVRRVLVPTGIYDFVWHPALFNTALYCCLFYLISRLFV
What are the official names of this protein?
Protein AaeX.
What is the protein family that this protein belongs to?
Belongs to the AaeX family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARGP_PHOLL
Sequence: MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENLFGQPLLVRTVPPRPTEQGQKLLALLHQVELLEEQWLGNEQGTDTPLLLSLAVNADSLATWLLPALHPVLADLPIRLNIQVEDETRTQEQLRRGEVVGAVSIQPQPLPSCLIDKLGALDYLFVASPEFATRHFPNGVTRSALLKAPAVAFDHLDDMHQAFLQQNFELSPGSVPCHIVNSSEAFVQLAKQGSTCCMIPHLQIDQELKNGELIDLTPGLCQRRMLYWHRFAPESRTMKKVTDALLKLGRQMLRQDDIN
What is the function of this protein?
Controls the transcription of genes involved in arginine and lysine metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator ArgP.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: RUVB_LEUMM
Sequence: MTEDNPQFNQWYEQDTEVDHLLRDAAANDEEQRSELSLRPQFLREYIGQEALKEELNVYISAAKQREEALDHVLLFGPPGLGKTTLAMIIANEMNVNIKTTSGPAIEKPGDLVALLNELEPGDILFIDEIHRIPTNIEEIMYSAMEDYFVDIMVGQGPTARPVHFPLPPFTLIGATTRPGMLSKPLRDRFGIINSLQYYTPEELQQIVVRTADIFNAPIKSEGAYEISLRSRGTPRIANRLLKRVRDFAQVEGKDAIDKNIVTIGLDKLRVDNRGLDETDHKLLETMIEYYKGGPVGLNTIAANIGEESETLEAMVEPYLLQIGFLQRTPRGRVVTEAGYTHLGHAYQRKL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ILVC_CITK8
Sequence: MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDIAYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSDVVRSVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVEEGTDPAYAEKLIQYGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKTIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKAFMTEIQPGDLGKAIAEGAVDNAQLRDVNEAIRGHAIEKVGQKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: VATE_ARCFU
Sequence: MPLDKVLQEIQQKGEEEVRRIREETEKEVEKILAEAKAEAEEILKKAREEAEKEAEAIRRQEISSVKLEMKRELLNVQKEILEEVFNLLRQKVRDMDEETRKKILKNLLEKNASPGMVVYSRKEDEDIVKELIKELKLDVTYGGNIDCIGGVILEDPAGDIRLNLTFDELVSQVYEQKLSEVSKLLFK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: LV151_HUMAN
Sequence: MTCSPLLLTLLIHCTGSWAQSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSA
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
What are the official names of this protein?
Immunoglobulin lambda variable 1-51, Ig lambda chain V-I region BL2, Ig lambda chain V-I region EPS, Ig lambda chain V-I region NEW, Ig lambda chain V-I region NIG-64.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: DNAT_ECO45
Sequence: MSSRVLTPDVVGIDALVHDHQTVLAKAEGGVVAVFANNAPAFYAVTPARLAELLALEEKLARPGSDVALDDQLYQEPQAAPVAVPMGKFAMYPDWQPDADFIRLAALWGVALREPVTTEELASFIAYWQAEGKVFHHVQWQQKLARSLQIGRASNGGLPKRDVNTVSEPDSQIPPGFRG
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: IND12_ECOLI
Sequence: MWTGKKVDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI
What is the function of this protein?
Involved in the transposition of the insertion sequence IS2.
What are the official names of this protein?
Transposase InsD for insertion element IS2-12.
Protein: RS12_TETTH
Sequence: MGVGKPRGIRAGRKLARHRKDQRWADNDFNKRLLGSRWRNPFMGASHAKGLVTEKIGIESKQPNSAVRKCVRVLLRKNSKKIAAFVPMDGCLNFLAENDEVLVAGLGRQGHAVGDIPGVRFKVVCVKGISLLALFKGKKEKR
What are the official names of this protein?
40S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: FASE_ECOLX
Sequence: MKYLFTILLIFICKYGYTFVSNPLLYPFPNDTKIIIHSEGNGKIKKGILKITNPGESPWIVQSWTEGSEGKKTAVYPALARIEAKSSLVLKIYPQPNDKDKSEWMVVLFIPPDSLRKPSELTIPIAYRLKII
What are the official names of this protein?
Protein FasE.
Protein: PLYD_NEOFI
Sequence: MYQKSLLFSLLATSALAQFPIPDSKGSVTFDAPYEVAAGKTYDGGYKTYGRGVSCSGQGEGGQDDAVFLIQEGGTLKNAIIGSDQIEGVYCLGACTIENVWWEAVCEDALSLKGGSGPYNIIGGGAQGADDKVIQHNSGGQVNIDGFTVYDFGKLYRSCGNCDEQHARTVTIRNVVANSGKTLVGINSNLGDTASIDSSTCATDVKKICVEYKGNNSGDEPEEVSEGPSDACQYSEPLSSC
What is the function of this protein?
Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.  Favors pectate, the anion, over pectin, the methyl ester (By similarity).
What are the official names of this protein?
Probable pectate lyase D.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLE10_ARATH
Sequence: MKTNRNRPINILIVFFLLTTARAATRNWTNRTHRTVPKVQHAYYAYPHRSCESFSRPYARSMCIELERIHRSSRQPLFSPPPPPTEIDQRYGVEKRLVPSGPNPLHN
What is the function of this protein?
Extracellular signal peptide that regulates cell fate.  Represses root apical meristem maintenance.  Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2 (PubMed:28607033).
What are the official names of this protein?
CLAVATA3/ESR (CLE)-related protein 10.
What is the protein family that this protein belongs to?
Belongs to the CLV3/ESR signal peptide family.
What are the subcellular locations of this protein?
[CLE10p]: Secreted, extracellular space.
Protein: X193_ECOLX
Sequence: MKKWMLAICLMFINEICHATDCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGINPEHLTTDPCMNIYTGAYYLAIAFKKWGITWEAVGAYNAGFRKTERQNQRRLAYASDVYRIYTGIKSSKGIRIPVTKKSLPEINSVQNN
What are the official names of this protein?
X polypeptide, ORF 19, ORF169, P19 protein.
What is the protein family that this protein belongs to?
Belongs to the IagB/IpgF/P19 family.
Protein: TCPR2_HUMAN
Sequence: MASISEPVTFREFCPLYYLLNAIPTKIQKGFRSIVVYLTALDTNGDYIAVGSSIGMLYLYCRHLNQMRKYNFEGKTESITVVKLLSCFDDLVAAGTASGRVAVFQLVSSLPGRNKQLRRFDVTGIHKNSITALAWSPNGMKLFSGDDKGKIVYSSLDLDQGLCNSQLVLEEPSSIVQLDYSQKVLLVSTLQRSLLFYTEEKSVRQIGTQPRKSTGKFGACFIPGLCKQSDLTLYASRPGLRLWKADVHGTVQATFILKDAFAGGVKPFELHPRLESPNSGSCSLPERHLGLVSCFFQEGWVLSWNEYSIYLLDTVNQATVAGLEGSGDIVSVSCTENEIFFLKGDRNIIRISSRPEGLTSTVRDGLEMSGCSERVHVQQAEKLPGATVSETRLRGSSMASSVASEPRSRSSSLNSTDSGSGLLPPGLQATPELGKGSQPLSQRFNAISSEDFDQELVVKPIKVKRKKKKKKTEGGSRSTCHSSLESTPCSEFPGDSPQSLNTDLLSMTSSVLGSSVDQLSAESPDQESSFNGEVNGVPQENTDPETFNVLEVSGSMPDSLAEEDDIRTEMPHCHHAHGRELLNGAREDVGGSDVTGLGDEPCPADDGPNSTQLPFQEQDSSPGAHDGEDIQPIGPQSTFCEVPLLNSLTVPSSLSWAPSAEQWLPGTRADEGSPVEPSQEQDILTSMEASGHLSTNLWHAVTDDDTGQKEIPISERVLGSVGGQLTPVSALAASTHKPWLEQPPRDQTLTSSDEEDIYAHGLPSSSSETSVTELGPSCSQQDLSRLGAEDAGLLKPDQFAESWMGYSGPGYGILSLVVSEKYIWCLDYKGGLFCSALPGAGLRWQKFEDAVQQVAVSPSGALLWKIEQKSNRAFACGKVTIKGKRHWYEALPQAVFVALSDDTAWIIRTSGDLYLQTGLSVDRPCARAVKVDCPYPLSQITARNNVVWALTEQRALLYREGVSSFCPEGEQWKCDIVSERQALEPVCITLGDQQTLWALDIHGNLWFRTGIISKKPQGDDDHWWQVSITDYVVFDQCSLFQTIIHATHSVATAAQAPVEKVADKLRMAFWSQQLQCQPSLLGVNNSGVWISSGKNEFHVAKGSLIGTYWNHVVPRGTASATKWAFVLASAAPTKEGSFLWLCQSSKDLCSVSAQSAQSRPSTVQLPPEAEMRAYAACQDALWALDSLGQVFIRTLSKSCPTGMHWTRLDLSQLGAVKLTSLACGNQHIWACDSRGGVYFRVGTQPLNPSLMLPAWIMIEPPVQPAGVSLVSVHSSPNDQMLWVLDSRWNVHVRTGITEEMPVGTAWEHVPGLQACQLALSTRTVWARCPNGDLARRYGVTDKNPAGDYWKKIPGSVSCFTVTASDELWAVGPPGYLLQRLTKTFSHSHGTQKSSQAAMPHPEDLEDEWEVI
What is the function of this protein?
Probably plays a role as positive regulator of autophagy.
What are the official names of this protein?
Tectonin beta-propeller repeat-containing protein 2, WD repeat-containing protein KIAA0329/KIAA0297.
What is the protein family that this protein belongs to?
Belongs to the WD repeat KIAA0329 family.
Protein: PURL_IGNH4
Sequence: MPLTEEELKLIEETLGRKPNQVELAMFEAQWSEHCSYKSSRKHLRKLKMDSPWVVKGGDAAVVDFGSVYVAFRIESHNHPSAVDPYNGAATGVGGIIRDILSSGAKPIALLDDLIFGDLDENLVKWHVKGVVKGISDYGNRVGVPTVGGETWFDPDFTRNPMVSVACVGVCPKDKLINGTPRPGDLIVIAGNYTGKDGLLGSSFASKNLEEGVEEEYAAIQVPDPLMEKLLIDSILEMRDERLLVFVKDLGGGGLATALSEVAASFGLGVEARLDALHLREPMEAWEIVVSESQERMMLVIRPEDLERAKKVLEKYDVPYSVIGKFTDTGRVVLYYNGEKVADLPAKFLAEGPELDRPYERPKWHLELELLPPLPEVDLGDAIRKVLSSPNVASKRWIYEQYDHEVQIRTVVKPGEGDAAVLRLLEDPPKGIAVATDSNPRYTFLDPLWGAADVFLEAYRNVVASGARPLAAVDQVDAGSPERPDRFWFFVRMIDGLAWVEREVDVPIVGGKVSFYNEDDVTGKQIKPTVMITMIGKVENVYNAKRARAEEGDLLVLVGETFPELGGSEFLWSVHKLVRGKPPVPRPSTEARVAERILKAIKVSGVTGVHDVSVGGLAAAVAELAKGFGATLELDKVKGPWKRPEEALFSESGARYLLAVKPEAAEEVLKVTGGTVVGKVGGGPLRVLLNGKEVASVDDFEDLLENGMTSRLV
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.