PharMolix/UniProtQA huggingface dataset:
Protein: TATA_XANAC
Sequence: MGGFSIWHWLIVLVIVLLVFGTKRLTSGAKDLGSAVKEFKKGMHDDDKPAGKLGDDSRTAEQAREAQAERDRDAR
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: AROC_RHIWR
Sequence: MSFNSFGRVFRFSTWGESHGPAIGAVVDGCPPGLELSEADIQPWLDKRRPGTSRFTTQRQEPDQVRILSGVFEGRTTGTPISLMIDNVDQRSKDYSEVALAYRPGHADYAYDAKYGFRDHRGGGRSSARETASRVAAGAVARLVIPEVRIRAYLIELGGDRIDPAAFDDAAIDENPFFCPDRAAAARWEAIVDDARKAGSSVGAVVECVAEGVPAGWGAPLYAKLDSELAAACMSINAVKGVEIGDGFAAARLTGETNADPMRPGNDGKPVFLANHAGGIAGGIATGQPVVVRIALKPTSSILTPVETIGRDGKAADIRTKGRHDPCVGIRAAPVLEAMVALVLADQKLLHRAQIG
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RS12_CITBB
Sequence: MPTINQLIRHGRESKGDKSTAPALRSCPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGVEVTSYIPGVGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGTLDSVGVKGRMKSRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: KYNU_YEAST
Sequence: MEKALELDGEYPESLRDEFNIPTFKSMGLSSDDKPVTYLCGNSLGLMPKSTRNSINAELDAWSDCAVESHFKHPEEARGKVPWVSIDLPILPLLAPIVGAQENEVAVMNSLTANLNSLLITFYKPTEKRFKILFEKGSFPSDYYAFYNQCKIHGISEPENVFIQIEPREGETYIRTQDILDTIEVNQDELALVCLSGVQYYTGQYFDIGRITSFAHQFPDILVGWDLAHAVGNVPLQLHDWGVDFACWCSYKYLNAGPGGIGGLFVHSKHTKPDPAKESLPRLAGWWGNDPAKRFQMLEVFEPIPGALGFRQSNPSVIDTVALRSSLELFAKFNGINEVRKRSLLLTNYMTELLEASKYYKHPLRIEKLPCFFTILTPTSTDEEHGAQLSLYFDSDTGKEDIMPKVFQYLHDHGVIGDARRPNVIRLAPAPLYNTFSDVYIAVNALNEAMDKL
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, Biosynthesis of nicotinic acid protein 5, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL15_FRATO
Sequence: MKLNTLAPAAGSKSAPKRLGRGIGSGLGKTSGKGHKGQKARSGGYHKVGFEGGQMPLQRRLPKFGFPSASKRYVAEIRLHELNNVVADEVTLDTLKDFGLIRKDIKTVKVIASGEIQKAVSLKGIACTKGAKEAIEKAGGKVE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: YD31_HELPJ
Sequence: MHDFLKAFKDAFPHTISIFLGYLLMGMTFGMLLAQQGYDYKVALFMSLFIYAGAIQFVAITLLSAQASLMNVVIVSLLVNARQTCYALSMLDRFKNTKWRLPYLAHALTDETFALLNLYAPKKGVNETDFMFSISLLNHSYWIFGSLVGSLVGSHFSFDTQGMEFVMTAIFIVLFMEQYKRNTNHKNAWLGIAIAVVCLALFGTEYFLLIALVLMVLALILFRKQLEC
What are the official names of this protein?
Uncharacterized membrane protein jhp_1251.
What is the protein family that this protein belongs to?
Belongs to the AzlC family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAPSD_BPSK2
Sequence: MENITRELFDQYISRQAQLNRVSPAAVAAKFAVDPTVQQKLEAAAQESDSFLSKINVFGVTQQIGQKVLIGSKGPLAGVNNSTTTRRNPADNSKMEPYDYMCRKVNYDYGISYEQLDAWAHQPNFQPLISSAMARQMSLDRIMIGFNGTSYADPSNRAANPLLQDCGIGFLEKIRKEAPHRVISNITVTSRDEDNKIITKGTYGNVSAAVYDAKNSLMDEWHKRNPDNVVILAGDLLTTSNFPAINAMSQTNPNTEMLAGQLIVAQERVGNMPTFIAPFFPVNGILITPFKNLSIYYQRGGLRRTIKEEPEYNRVATYQSSNDDFVVEDYGNVAFIDGITFAQPENGG
What are the official names of this protein?
Major capsid protein, Major capsid protein B, Major head protein.
What is the protein family that this protein belongs to?
Belongs to the P2-like viruses major capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: PSBZ_LIRTU
Sequence: MTIAFQLAVFALIATSSILLISVPVVFASSDGWSSNKNVVFSGTSLWIGLVFLVAILNSLIS
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: RECA_CLOB8
Sequence: MGIINAEKLKAIESAMSHIEKQFGKGSVMKLGDHNISNMDAISTGCLDLDIALGIGGVPKGRIIEIYGPESSGKTTIALHIAAESQKKGGAVGYIDAEHALDPSYAQKLGVDVDSLIISQPDTGEQGLEIAEALVRSGAIDVLVVDSVAALVPKAEIEGEMGDSHIGLQARLMSQALRKLAGTINKTNCVAIFINQLREKVGVMFGSPETTTGGRALKFYASVRLDIRRIDSIKQGDSIIGNRTRIKVMKNKVAPPFKQAEFDIMYNEGISRCGNIVDVGVKEEIVQKSGAWFSYGDIRLGQGRENAKLYLKENPEVALDIENQIREKYNLPPAELFKAAAPEGAKENISAKDDVAVDTKE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NGDNB_XENLA
Sequence: AAAGDVILEDVPGSVNLFNTLQDQITKVTAHVQDLTQKVRSSIYNTDKGLSFLELKDQLLLFYLQDLTHLMLEKTNGKSIKGNPGILRLVELRTVLEKMRPIDQKLKYQIDKLVKAAVTGSLGENDPLRFKPNPQNLMSKLSEPDERESDSGEEGAEGGVAKKPQSKVKRYIPPRLAPVHYDDTEAEREHRIVERAKKLALSSSTIRELKEQYSDAPEEIREGRAYHMMRHDKEEQHRINHEESMMVRLNMTRKEKARKKRVLSMTSQLNSLTHFSDISALTGGEGRAEDMVPFMKKSKKGPKKSKKKKGFSRRRH
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (By similarity).  May inhibit mRNA translation (By similarity).
What are the official names of this protein?
Neuroguidin-B, EIF4E-binding protein B.
What is the protein family that this protein belongs to?
Belongs to the SAS10 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: SNAB_BOVIN
Sequence: MDNAGKEREAVQLMAEAEKRVKASHSFLRGLFGGNTRIEEACEMYTRAANMFKMAKNWSAAGNAFCQAAKLHMQLQSKHDSATSFVDAGNAYKKADPQEAINCLNAAIDIYTDMGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIFEQIGANTMDNPLLKYSAKDYFFKAALCHFIVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRLDQWLTTMLLRIKKSIQGDGEGDGDLK
What is the function of this protein?
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
What are the official names of this protein?
Beta-soluble NSF attachment protein, SNAP-beta, N-ethylmaleimide-sensitive factor attachment protein beta.
What is the protein family that this protein belongs to?
Belongs to the SNAP family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: DBP2_DEBHA
Sequence: MSYNNNSDSYGGGYNSYGGNSYGGGGYGGGRGGGRGGFGGRGGGRYDERVELNTPEWDIDSLPKFEKNFYNEHPDVTARSVQDVNAFRKEHDMKCDGTDIPKPITSFDEAGFPDYVLKEVKQQGFPKPTSIQCQGWPMALSGRDMVGIASTGSGKTLSYCLPSIVHINAQPLLSPGDGPIVLVLAPTRELAVQIQQECSKFGSSSRIRNTCVYGGAPKGQQIRDLARGVEICIATPGRLIDMLETGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVQALTRDYLNDPIQVTVGSLELAASHTITQLVEVVTEFEKRDRLIKHLETATADPEAKCLIFASTKRTCDEITNYLRADGWPALAIHGDKQQGERDWVLKEFKTGKSPIMVATDVAARGIDVKGISYVINLDMPGNIEDYVHRIGRTGRAGSTGTAVSFFTDNNSKLGGDLCKIMREANQTIPPELMRFDRRSFGSHIRYGRGGGRGGFRGGRGRGGFRGGRGGYQSGSNSAPLGNARRY
What is the function of this protein?
ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
What are the official names of this protein?
ATP-dependent RNA helicase DBP2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LIVM_ECOLI
Sequence: MKPMHIAMALLSAAMFFVLAGVFMGVQLELDGTKLVVDTASDVRWQWVFIGTAVVFFFQLLRPAFQKGLKSVSGPKFILPAIDGSTVKQKLFLVALLVLAVAWPFMVSRGTVDIATLTMIYIILGLGLNVVVGLSGLLVLGYGGFYAIGAYTFALLNHYYGLGFWTCLPIAGLMAAAAGFLLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTLFGLEFSRTAREGGWDTFSNFFGLKYDPSDRVIFLYLVALLLVVLSLFVINRLLRMPLGRAWEALREDEIACRSLGLSPRRIKLTAFTISAAFAGFAGTLFAARQGFVSPESFTFAESAFVLAIVVLGGMGSQFAVILAAILLVVSRELMRDFNEYSMLMLGGLMVLMMIWRPQGLLPMTRPQLKLKNGAAKGEQA
What is the function of this protein?
Part of the binding-protein-dependent transport system for branched-chain amino acids.  Probably responsible for the translocation of the substrates across the membrane.
What are the official names of this protein?
High-affinity branched-chain amino acid transport system permease protein LivM, LIV-I protein M.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TXA25_ANDAU
Sequence: MMKLVLFSVIVILFSLIGSIHGADVPGNYPLDRSGKKYPCTITWKKNPSCIQICKKHGVKYGYCFDFQCWCEIFGRLKTFKI
What is the function of this protein?
Shifts the voltage of activation of para/tipE voltage-dependent sodium channels (Nav) toward more negative potentials.
What are the official names of this protein?
Beta-insect toxin AaBTxL1, Neurotoxin AaBTX-L1, Peptide AaF1CA25.
What is the protein family that this protein belongs to?
Belongs to the long (3 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: REX_MARSD
Sequence: MKTQNIPKATIKRLAVYIQVLTGLKRDGVEVISSEKLARACSVNPSQIRKDLAYFGEFGVRGVGYYVHELISSIKQSLGVDRVWGCALVGVGNLGRALLRHKEFALRGFSIRAAFDCDPYKIGEVVSGLEVVCTRQFKARVEELGLEIGIITTPPERAQRAANYLVDGGIKGIVNFAQARIDVPKNVPVEYVDFTHHFYSVAFNISSME
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3P_STRCO
Sequence: MTIRVGINGFGRIGRNYFRALLEQGADIEIVAVNDLGDTATTAHLLKYDTILGRLKAEVSHTEDTITVDGKTIKVLSERNPADIPWGELGVDIVIESTGIFTKKADAEKHIAGGAKKVLISAPAKDEDITIVMGVNQDKYDPANHHVISNASCTTNCVAPMAKVLDENFGIVKGLMTTVHAYTNDQRILDFPHKDLRRARAAAENIIPTTTGAAKATALVLPQLKGKLDGIAMRVPVPTGSATDLVVELQREVTKDEVNAAFKKAADDGDLKGILFYTEDAIVSSDITGDPASCTFDSSLTMVQEGKSVKILGWYDNEWGYSNRLVDLTVFVGNQL
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE3_ALTMD
Sequence: MDLLPRERDKLLIFTAALLAERRLKRGVKLNYPEAMAYISMEIIEGARDGKTVAEMMDYGRTLLTKEQVMEGVSELIPEVQVEATFPDGTKLVTIHNPII
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_KLEP3
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAMKEAGITVDYVLEFDVPDELIVDRIVGRRVHAASGRVYHIKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYHQMTAPLIGYYTKEAQAGNTKYAKVDGTKAVADVRAELEKILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_FRATW
Sequence: MIIADNIKQFHSIRNSLIKQQKIGFVPTMGALHNGHISLIKKAKSENDVVIVSIFVNPTQFNNPNDYQTYPNQLQQDIQILASLDVDVLFNPSEKDIYPDGNLLRIEPKLEIANILEGKSRPGHFSGMLTVVLKLLQITKPNNLYLGEKDYQQVMLIKQLVKDFFINTKIIVCPTQRQPSGLPLSSRNKNLTSTDIEIANKIYEILRQDDFSNLEELTNKINSTGAKLQYIQKLNNRIFLAFYIGKVRLIDNFLKETGPSC
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_FRATH
Sequence: MLDAKYVKDNLQQVAEKLATRGYQFDIAEFEAQEQKRKHLQERTQDLQSQRNTISKEIGQKKAKGEDTSDIFAKVNQINEELKIIEKELKDLQDTINQTLLSMPNLPADDVPVGKDENDNVEIRRWGTPREFHPEAPAKDHSDIGEILKMIDFKAAAKVTGSRFMVLKNKIAKLHRALSQFMLDLHTEKHGYEELYVPYLVNNDSLYGTGQLPKFAANLFKLEGDFEYSLIPTAEVPITNLVRDEILDTETLPRYYTAHTPCFRSEAGSYGRDTKGMIRQHQFEKVELVHITTADKGEESLELLTSHAEKVLQKLNLPYRVMKLCTGDMGFSAKKTYDLEVWLPSQNTYREISSCSWCGDFQARRMKARHKNPSMKKPELVHTLNGSGLAVGRTLLAIIENYQQEDGSIMVPDALIKYMGGISVIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTC9C_HUMAN
Sequence: MEKRLQEAQLYKEEGNQRYREGKYRDAVSRYHRALLQLRGLDPSLPSPLPNLGPQGPALTPEQENILHTTQTDCYNNLAACLLQMEPVNYERVREYSQKVLERQPDNAKALYRAGVAFFHLQDYDQARHYLLAAVNRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFG
What are the official names of this protein?
Tetratricopeptide repeat protein 9C, TPR repeat protein 9C.
What is the protein family that this protein belongs to?
Belongs to the TTC9 family.
Protein: ACVR1_MOUSE
Sequence: MVDGVMILPVLMMMAFPSPSVEDEKPKVNQKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
What is the function of this protein?
Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed:10479450, PubMed:15531373, PubMed:21945937).  As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B.  Upon binding of ligands such as BMP7 or BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain.  In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal.  In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor.  Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (PubMed:25413979, PubMed:10479450, PubMed:15531373, PubMed:21945937) (By similarity).
What are the official names of this protein?
Activin receptor type-1, Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, TSK-7L.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: HSLU_HISS2
Sequence: MSEMTPREIVSELDQHIIGQADAKRAVAIALRNRWRRMQLQEPLRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDSAMKLVRQTEIEKNRFRAEEMAEERVLDTLLPPAKDQWGQIEERDTNTNTRQIFRKKLREGQLDDREIEIDIAAPNIGVEIMAPPGMEEMTNQLQSMFQNLSSGQTKKRKMKIKDALKALIDDEAAKLINPEELKQKAIDAVEQNGIVFIDEIDKICKKGEYSGADVSREGVQRDLLPLVEGSTVNTKHGMVKTDHILFIASGAFQVARPSDLIPELQGRLPIRVELSALTAKDFERILTEPNASLTEQYQALMATEGVDIEFTESAVKKIAEAAFRVNEKTENIGARRLHTVMERLMDKISFDASEMSGQNVIIDGDYVTGALGDVVENEDLSHFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7L_LEIXX
Sequence: MRGTRVTETASAPRMAPGPPTLDDPWPVALLASKIRGWIERLGTAWVEGEITQWGVSGGNVYGKLKDLNEDATVGFTIWSSVKARIPADLKQGDRVIAAVKPNYWLKGGTLTMQVSDMRHVGLGDLLERLERLRAQLRAEGLFRPERKKRLPFLPHTIGLVTGKDSDAEKDVLRNAQLRWPQVRFRTVYAAVQGDRTVPEVTAALRELDADPEVEVIIVARGGGDFQNLLGFSDESLLRAAAGLSTPLVSAIGHEADRPLLDEVADLRASTPTDAAKRVVPDVAEELVRVHQARARIGTRLTHIIRHEIDRIGHLRTRPALASGSWIVDSRAQDLTRFVARGAELVERCVDREAARVAELRGQLRALSPQATLERGYAIVQNAAGRVVAAPGEAPAGTELRITVSGGSLAATAGKALPSPAQGATNGSLAAPRGK
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_PSYIN
Sequence: MSDQVIIFDTTLRDGEQALSASLTVKEKLQIAFALERLGVDVMEVGFPISSPGDFESVKTIAREIKNSRVCGLSRALPKDIDAAWNALKGADAFRIHTFISTSTIHVENKLKRTFDAVLEMGINAVKHARNYTDDVEFSCEDAGRTPIDNLCRIVEEAIKAGATTINIPDTVGYTYPSEFGGIIKTLFNRVPNIDQAIISVHCHDDLGMSVANSITAVENGARQIECTMNGLGERAGNCSLEEVAMILQTRKDKLGFTTNVNPMEISRTSQLVSQLCNMPIQANKAIVGANAFSHSSGIHQDGVLKSQNTYEIMTPESVGISTNKLNLTSRSGRHVIQHRMQELGYRDTDYDLEQLYASFVELADKKGQVFDYDLEALMFFNKVDSDPQHYRLESINVQSGSGLVATATIVMSIGEDKKVVEAATGNGPIDAAYQCLMRISGLDINMDDYHINAKGAGKDALGQVDIVATYNGQKFHGLGLSTDIIESSTKAMVHVMNHIHLAKAVAIEKEQLIHIDQV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: RS7_RHORT
Sequence: MSRRRAAEKREVLPDAKFGDLVLAKFINSVMLQGKKAVAEKIVYGAFERIQSKTGQDPVKVFHDALDNVKPSVEVRSRRVGGATYQVPVEVRPDRRQALGLRWLIDFARKRSETTMVDRLTGEFLDAASNRGGAVKKREDTHRMADANKAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: TCPD_YARLI
Sequence: MSVPTGTKSGFKNKEKPLEVRKSNILAARAVADAIRTSLGPKGMDKMIQTARGQVIISNDGNTILQHMAVMHPAAKMLVDLSASQDSVAGDGTTSVVILAGSLLGAADKLLKKGIHPSIIAENFQKAAQRAAEVVMDMSKPIDLSDRETLIRAASTSLNSKIVSQFSSTLAPMLVDAALQAAKKTPEGGLTLDLNDIRIIKSLGGTIEDTTLANGLVLNNYAVKNAGGPSRMEKAKIGLIQFQLSAPKPDMENHIVVNDYRQMDKILKEERQYILGLAKAIKKSKCNVLLIQKSILRDAVSELALHFLAKLNIMVIKDIERDDIEFISRSTGAKPVADIEAFTEDKLGSCDLVEEVESSGSKTVRFSSREGSNTVSILVRGANDLVIDETERSLHDALCVLRSLFRVPALVPGGGACEVQVAQVIGKESRAMDGASAICYEEFSNAMLVIPTTLAENAGLNPVNVVTELRVRHEKGEVNAGISVRRGTSIMVEEHVIQPALVTTSAITLAAECAKGLLRIDDIAFSR
What is the function of this protein?
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.  Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
What are the official names of this protein?
T-complex protein 1 subunit delta, TCP-1-delta, CCT-delta.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_SULAC
Sequence: MPSPQQRSGSFRKVFVKLPSGKSTIHYERRKDNIARCGMCKKPLNGVKNNYTYKYSKTEKRPERVYGGYLCHKCLESLIKMTIRGIS
What are the official names of this protein?
50S ribosomal protein L34e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL34 family.
Protein: WDR53_BOVIN
Sequence: MAVKWTGGHSSPILCLNASQEGLVASGAEGGDLVVWGEDGTLLGHTCFQGAEDVTNVLFSPSCPTKLYASHGETISILDVRSLKEPLDDFHVNEEEINCLSLNETENLLASADDSGTIKILDLENKKISRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWNLRKARPLWITNLQEDETEEMESPQSPGQLLNPALAHSVSVASCGNVFSCGAEDGKVRIFRVMGVKCEQELGFKGHSLGVSQVCFLRESYLLLTGGNDGKIKLWDVSSEIEKKHKSPTKHTHRKKTKRAAYTKQGGGTHASVTGEDEHGKILPKLSIEHGEKVNWLLSTKIKGYRNILVADQTSCISVYPLKEF
What are the official names of this protein?
WD repeat-containing protein 53.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR53 family.