PharMolix/UniProtQA huggingface dataset:
Protein: IF2_SYNC1
Sequence: MGKKIRVYELAQKMGVDNKVLLEKLHEAGIDAKSHMSVLSEEDVEKLDEAPAKVERVEERRITAGVIRRRRKEVPQEEKAAPPAAAEEPSSVDTAVAEEAPAEEVQPVSDQPEIAVEPPPAGKQEEVAAPAPEPKAEEPVVEEVIAEPAVEEVVEEPSAVEQEEHVETTPVAEEEPKVEEQPSVEAESKAVSGELEESKTADQSKGQSEAAEVSVTKEKPKVEKATANRAKILGRVELSTLTSPPKRQERAKNGKGRPERPKGAKPSGGPAPRAKEAAPQAAVPFDGGPAPDKEVRGGKKGKKGKGNSYDKDKGFADGGKGRRARRQVYEPERDERRMRRGKKTPKPQKKTEVTVSKAIKRIIRISDVITVGELAKRMGVKSKDLITELMRQGQMVTINHPLDFETAAILASEFNYEVENVAFDEENLLADTAAVTEEGDSEEGCVPRPPVVTIMGHVDHGKTSLLDAIRATNVTGGEAGGITQHIGAYDVSVDDKKITFLDTPGHEAFTSMRARGAKVTDIVILVVAADDGVMPQTKEAINHSKAAGVPIIVAVNKMDKPDANSDRVKQELTEFEMIPEEWGGDTIFVEVSAKNRTNLDSLLEMVLLQAEVLELKANPNKRAKGAIVEARLDRGRGPVATVLVEEGTLRIGDPIVSGLHYGKVRTMTNDRGERLEEAGPACPVEVTGLSGTPTAGDSFHAVESEKDAKEVATHRQRKVREQELASTSKISLEQLYARMQEGEVQELKVIIKADVQGSVEAVRDSLVKLSTDACRLVVIHTAVGGINESDVSLASASDAIILGFNVRAESKAAALAETEGVDIRFYNVIYDAVNDIRDAMEGLLAPTLREKHLGKVEVRETFHVSKVGTIAGCYVTEGKVLRNAQVRLIRDHVVIWEGKLASLKRFKDDAREVQNGYECGLSLENYNDIKVGDIIEVFEMEEVKTSL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_SHESA
Sequence: MWLGVITLFPEMFRAVTDFGVTGRAVKNGLLELHTWNPRDFTHDRHSTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEEAKVIYLSPQGRKLDQQGVTELAESSRLILVCGRYEGIDERIIQTEVDEEWSVGDYVLSGGELPAMTLIDAVSRLVPGVLGKQASAEQDSFSDGLLDCPHYTRPESLDGLDVPAVLLSGNHEQIRLWRLQQSLGRTFLRRPELFENLALTDEQSTLLAQFVEAMDKNA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISX1_TRIV2
Sequence: MLVLKTTDQEFSTRFQSLVSDRREATVDVSGTVRDILAHVKAHGDAAVQEYTSRFDHYSPHSHHLSAAFIAEQAAKCSAEVKAAIELAAERISSFHQKQLPQDIGYTDTVGVKLGLNWVALSQVGIYVPGGRASYPSSVLMNALPAKIAGVERIVMTVPMPHGEINPAVLAAAQVAGVTEIYSIGGAQAVGALAYGTETITPVDKIVGPGNAYVAEAKRQVFGTVGIDSIAGPSEILVVADRQNNPEWIAWDLLSQAEHDPSAQSILITDSESFAQQVIGAVEQILTTLPTTKVASSSWQNHGAVIIVRDLAESIPLLNQLAPEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIGDYLGGPNHVLPTSRSARFASGLSVYDFLKRITYLECNQAALQAIGQSAVTLAETEGLPAHAGSVAVRLQGLNDM
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase 1, HDH 1.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: YAFD_ESCF3
Sequence: MRKNTYAMRYVAGQPAERILPPGSFASIGQALPPGEPLSTEERIRILVWNIYKQQRAEWLSVLKNYGKDAHLVLLQEAQTTPELVQFATANYLAADQVPAFVLPQHPSGVMTLSAAHPVYCCPLREREPILRLAKSALVTVYPLPDTRLLMVVNIHAVNFSLGVDVYSKQLLPIGDQIAHHSGPVIMAGDFNAWSRRRMNALYRFAREMSLRQVRFTDDQRRRAFGRPLDFVFYRGLNVSEASVLVTRASDHNPLLVEFSPGKPDK
What are the official names of this protein?
UPF0294 protein YafD.
What is the protein family that this protein belongs to?
Belongs to the UPF0294 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_PSYIN
Sequence: MDKKASRLRRATRTRKKLQELGATRLVINRTPRHTYAQVITADAQVVASASTLEKEVRAQISNGGNKEAAQLIGKLVAERAVEKGISKISFDRSGFQYHGRVAALAEAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: DEFL_RICCN
Sequence: MNQDKPYYQIVYAPNDIFKKQAEYIDIVDDNIRTIVDKMLQNLHIERAVGLGANMVGILKRIAVVDLHENNKSSPIVFINPNITYFSEEKQTFIEGSLSFPGIEASITRSKAIKVKYLDYNGNKQELAAEGFLATVIQHEIEYLNGKTFLDSLSKLKRDTLLKKMLKHIKLHPPHIHGSGCRH
What are the official names of this protein?
Peptide deformylase-like, Polypeptide deformylase-like.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RAB33_CIOIN
Sequence: MLQSGEGSPTLPKRVFKIIVIGDSDVGKTCLTYRFCTGKFPEKTEATIGVDFRERTLDIDGEQIKLQLWDTAGQERFRKSMVPHYYRNVHAVVFTYDVTKGRSFQGLPSWIEECERYSLNASEIPRILVGNKCDLKDQAEVDTNSATRFADANSMPLFETSAKADSEMGNIEAIFLTVAHKLKSQKPMMKQDYPNMKRATVLSVDKEVLRTNEAPCSC
What are the official names of this protein?
Putative Ras-related protein Rab-33.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: PATM1_SOLTU
Sequence: MATTKSFLILFFMILATTSSTCAKLEEMVTVLSIDGGGIKGIIPAIILEFLEGQLQEVDNNKDARLADYFDVIGGTSTGGLLTAMITTPNENNRPFAAAKDIVPFYFEHGPHIFNYSGSIIGPMYDGKYLLQVLQEKLGETRVHQALTEVAISSFDIKTNKPVIFTKSNLAKSPELDAKMYDICYSTAAAPIYFPPHYFITHTSNGDIYEFNLVDGGVATVGDPALLSLSVATRLAQEDPAFSSIKSLDYKQMLLLSLGTGTNSEFDKTYTAQEAAKWGPLRWMLAIQQMTNAASSYMTDYYISTVFQARHSQNNYLRVQENALTGTTTEMDDASEANMELLVQVGETLLKKPVSKDSPETYEEALKRFAKLLSDRKKLRANKASY
What is the function of this protein?
Probable lipolytic acyl hydrolase (LAH), an activity which is thought to be involved in the response of tubers to pathogens.
What are the official names of this protein?
Patatin group M-1, Patatin class I.
What is the protein family that this protein belongs to?
Belongs to the patatin family.
What are the subcellular locations of this protein?
Vacuole.
Protein: NUOB_LEPCP
Sequence: MGIEGVLKEGFVTTSVDTLINWSKTGSLWPMTFGLACCAVEMMHAGASRYDIDRFGMLFRPSPRQSDLMIVAGTLCNKMAPALRKVYDQMAEPRWVLSMGSCANGGGYYHYSYSVVRGCDRVVPVDVYVPGCPPTAEALLYGILQLQAKIRRENTIAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SUCC_BEUC1
Sequence: MDLFEYQARDVFEKHGVPVLGGIVATTVDEARAAAETLTSGAGSVVVVKAQVKTGGRGKAGGVKLARSPEEAAEAAEQILGMDIKGHTVHRVMIAEGASIAEEYYFSVLLDRANRSYLAMASVEGGVEIEQLAVERPEALARVAVDPLVGIDAAKAAEIVAAAGFADDVAGAVADVIQKLWTVYDAEDATLVEVNPLVRTTDGRVIALDGKVTLDDNAEFRHPEHAELEDAASADPLEAKAKAHDLNYVKLDGEVGIIGNGAGLVMSTLDVVAYAGERHGGVKPANFLDIGGGASAAVMAAGLDVILGDPQVKSVFVNVFGGITACDEVARGIVQALEILGDKENKPLVVRLDGNAVEEGRAILAEANHPLVTLAETMDGGADAAAAAAHSAVTA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: LRC4C_HUMAN
Sequence: MLNKMTLHPQQIMIGPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTKIIIGCFVAITLMAAVMLVIFYKMRKQHHRQNHHAPTRTVEIINVDDEITGDTPMESHLPMPAIEHEHLNHYNSYKSPFNHTTTVNTINSIHSSVHEPLLIRMNSKDNVQETQI
What is the function of this protein?
May promote neurite outgrowth of developing thalamic neurons.
What are the official names of this protein?
Leucine-rich repeat-containing protein 4C, Netrin-G1 ligand, NGL-1.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Single-pass type I membrane protein.
Protein: NUOC_ROSCS
Sequence: MALDNPTVLARLQAALPDALLGSSEFRGDLSVHVRPERIVDVARFLRDDPELRYHFLENLCGVDYLGREPRFEVVYHLLSFANRHRICLKVGVSERNPSVPSLTELWPGANYHERETFDMFGIVFTGHPCLDRILMPEDWEGHPLRKDVPLGAEEVAFTFNQDRIYAHKPFAKE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NIFH_SINFN
Sequence: MAGLRQIAFYGKGGIGKSTTSQNTLAALVDLGQKILIVGCDPKADSTRLILNAKAQDTVLHLAAKEGSVEDLEVEDVLKVGYKGIKCVESGGPEPGVGCAGRGVITSINFLEENGAYDDVDYVSYDVLGDVVCGGFAMPIRENKAQEIYIVMSGEMMALYAANNIAKGILKYAHSGGVRLGGLICNERQTDRELDLAEALAAKLNSRLIHFVPRDNIVQHAELRKMTVIQYAPESQQAAEYRALADKIHANSGQGTVPTPITMEELEDMLLDFGVMKTDEQMLAELQAKEAAAAAQ
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein, Nitrogenase Fe protein, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: GUAA_BACP2
Sequence: MTNLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEEIKEMAPKGIILSGGPNSVYDEGSFRCDEKIFDLDIPVLGICYGMQLMTHYLGGKVEAASQREYGKADIHINGTPALFKDLPTDQVVWMSHGDLVVEVPEGFTVDATSAHCPNSAMSLAEKNFYGVQFHPEVRHSEYGNDLLKNFVFGVCDCDGKWSMENFIEIEMQKIRETVGDKQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDESDKLKGIDYLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGSELGIPDDIVWRQPFPGPGLGIRVLGEISEEKLEIVRESDAILREEIANFGLERDIWQYFTVLPDIRSVGVMGDARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEKISTRIVNEVKHVNRVVYDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: DUT_PSYA2
Sequence: MQAVQVKVLNPKITEDKAFSLPTRATDGSAGIDLRACIDEPLTIKAGTTHLIGTGLAIYIQDPNFAGMILPRSGLGHKHGIVLGNLVGLIDADYQGELMVSIWNRSLEDFVLNPAERMAQYVVVPVARPEFEVVTEFSDTSARGAGGFGHSGRQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RPC3_DANRE
Sequence: MTAQEVRLCGLLLQEHFGDVVENVGTHLIRNGVLTLRALAHETKLALDLVKKSLCVLVQHGMCTFGPGRRGPAGPVEYHINCEHILHMLRYPRYIYTAKSLYGDTGELIVEEILQRGQMTMSSTVKTVADRLTHNMPEGQSMDYNEVVSAFSRLVETHFLQRCPPMASAESSGTGSAETPPAVTQPSNPESHPDCYKLPYISLSGHGKRRRSSEDGEADQRAAKKAKTDSSECGDEGIHWQVNFERFHLHFRDQAIISAVSCKLDQTSGEIVRTMLRMSEVTTSANAAFTQALSANEIFRALPSNYNIARPILDQYLTLLVDDPMEFVGKAGDSGGGMFVVNLHRALANLARATLESVVQERFGSRSARIFRLLLRKRHLEQKQVEDFAMIPAKEAKEMLYTLLSENLVQLQEIPKTPDHAPSRTFYLYAVNQLPTARLLLQHCYKTVGNLIERRLYETKENKRLLEKSQRIEAILASLQATGAEATQLTEVEEMITAPERQQLESLRHHINKLDSGENQVDETIFLLESYINSTQASR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC3, RNA polymerase III subunit C3, DNA-directed RNA polymerase III subunit C.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPF2_RIPO1
Sequence: MFDFDATLPVMALQFILLAVILNGIFYTPLNKALDERADYIRQKETDEKERLAKAKELAQEYEKQLADARKQSQEVIAAAQADAQKIAAEALAKAQKEAQAKKEEAAVEIAQQRQAALGVLEQQVDVLSRQILEKLLGPELVK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
What are the official names of this protein?
ATP synthase subunit b', ATP synthase F(0) sector subunit b', ATPase subunit II, F-type ATPase subunit b', F-ATPase subunit b'.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PA_QRFVE
Sequence: MAFEAYRLLIANPQLYEPDFVSQAGELSEHWARENWKRREESLRHDKVCMLLMNTEPRERSHTQAEGEEEGSSSRSLATEEGEKRFSLEALEGLVDQGREVLLENLEMEEAQANSDSEGPNEADSGGEGEEFVFGVESESEMEVASEVTKLLEPDLIDSNFRYTLLEGVTSGKFAQMEFTALWGINTNNKWDLVDRVNRKLIEVKVTTRPPTGVWEEVVAHAEGTDPEHNGAYIIHDDLCGNFTPYKFGNISDLPGWPSAQDFPIRRHAFLASYGGVPSAGGIEEGLPAWDDVFMERTRNWVAPLWKKGPISVRRDDCPRMEPFNITKFITLLEDPRLRNTDKSAKWKGKILPVSWCRTIISSQEKDIDMVQEVIRDLGVIGLWEEINANPVKVERTVSALSELMRLFQEGFREKNPYISVKRKCKGWVITGHKQTPALTDTLLELGVGYKPYQMSNVVEEDMRQCETDDIEKMKWVDWMSKLAATESEPLGSKVSRDDIFKEAESRHVLDEPAKKMCSKVYDLYRSHKIGATCSKFMGFYSRMGGSYLRAIAGNSRQHSSLAIMPLYYKTYQEDGTSTRHLTGLVIRGPHHVRESTDTINLLIVEKTCLSRREAQERLSGGALVNGVWWVRKNAIRKADPTYLAFLHNSLFVPTNFLGELVTTPKHFLRQRQPRILGRNPVWQLWLL
What is the function of this protein?
subunit of the RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
Polymerase acidic protein, PA.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: BIOF_BURTA
Sequence: MNLLATLERGLADIDAQGLRRRRRIADTACSAHMSVDGREIVGFASNDYLGLAAHPRLIEAFAEGARRYGAGSGGSHLLGGHSRAHAALEDELAAFSGGFSDAPRALYFSTGYMANLAALTALAGRGATIFSDALNHASLIDGTRLSRANVQVYPHGDADALDALLRACDAPTKLIVSDTVFSMDGDVAPLARLVALAEAHGAWLVVDDAHGFGVLGPQGRGALAAHGLRSPNLVYVGTLGKAAGAAGAFIVAHETVIEWLVQRARSYIFTTAAPPSVACAVSASLAVIASDEGDARRAHLAALIERTRAILRATPWQPVDSHTAVQPLVIGSNEATLAAMAALDAQGLWVPAIRPPTVPAGTSRLRISLSAAHSFADLARLEAALVTPIEAAA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: RGAP1_MOUSE
Sequence: MDTTMVNLWTLFEQLVRRMEIINEGNESIEFIQVVKDFEDFRKKYQRTNQELEKFKDLLLKAETGRSALDVKLKHARNQVDVEIKRRQRAEAECAKLEQQIQLIRDILMCDTSGSIQLSEEQKSALAFLNRGQASSGHAGNNRLSTIDESGSILSDISFDKTDESLDWDSSLVKNFKMKKREKRRSNSRQFIDGPPGPVKKTCSIGSTVDQANESIVAKTTVTVPSDGGPIEAVSTIETLPSWTRSRGKSGPLQPVNSDSALNSRPLEPRTDTDNLGTPQNTGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRLVSHPECRDRCPLPCIPPLVGTPVKIGEGMLADFVSQASPMIPAIVVSCVNEIEQRGLTEAGLYRISGCDRTVKELKEKFLKVKTVPLLSKVDDIHVICSLLKDFLRNLKEPLLTFWLSKAFMEAAEITDEDNSTAAMYQAVSELPQANRDTLAFLMIHLQRVSQSPDTKMDIANLAKVFGPTIVAHTVPNPDPVTMFQDIKRQLKVVERLLSLPLEYWNQFMMVDQENIDSQRGNGNSTPRTPDVKVSLLGPVTTPEFQLVKTPLSSSLSQRLYNLSKSTPRFGNKSKSATNLGQQGKFFPAPYLK
What is the function of this protein?
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis.  Required for proper attachment of the midbody to the cell membrane during cytokinesis.  Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity.  Has a critical role in erythropoiesis (By similarity).  Also involved in the regulation of growth-related processes in adipocytes and myoblasts.  May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation.  Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA.  Essential for the early stages of embryogenesis.  May play a role in regulating cortical activity through RHOA during cytokinesis.  May participate in the regulation of sulfate transport in male germ cells.
What are the official names of this protein?
Rac GTPase-activating protein 1, Male germ cell RacGap, MgcRacGAP.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody, Midbody ring. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody ring, also called Flemming body. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase (By similarity). Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome.
Protein: GLYA1_MYCTU
Sequence: MTAAPDARTTAVMSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLHALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEFRPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAATPEFADRQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAEDLLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIATALATGSSVDVSALKDRATRLARAFPLYDGLEEWSLVGR
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.  Thus, is able to catalyze the cleavage of L-allo-threonine.
What are the official names of this protein?
Serine hydroxymethyltransferase 1, SHM1, SHMT 1, Serine methylase 1.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_SYNSC
Sequence: MRPRPCSILSLDVGRRRIGLAGCDALGISVTPLAALRRGRFDADLVVLQAHCCERSVQGLVVGLPLDAAGQPTAQAEHCQRYGLRLAAALDLPLAWVNEHSSTWAAGEQFGLKGDRSGRLDSAAAALLLEQWLAEGPELKPAQQTASRSGAGAGDGGS
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MT1_YARLI
Sequence: MEFTTAMFGTSLIFTTSTQSKHNLVNNCCCSSSTSESSMPASCACTKCGCKTCKC
What are the official names of this protein?
Metallothionein-1, MT-1, Metallothionein-I, MT-I.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 11 family.
Protein: HSLR_HAEIN
Sequence: MAEKEVRLDKWLWAARFYKTRSIAKAMIESGKVHYNNQRAKVSKIVEVGAMLKLRQGNEEKEIKIIALSDQRRGAPEAQLLYQETESSVKKREEIAWARKNNSLSMPHPDRRPNKKERRDLLKFKHQDKFE
What is the function of this protein?
Involved in the recycling of free 50S ribosomal subunits that still carry a nascent chain.  Binds RNA more specifically than DNA.  Binds with very high affinity to the free 50S ribosomal subunit.  Does not bind it when it is part of the 70S ribosome (By similarity).
What are the official names of this protein?
Heat shock protein 15 homolog, HSP15.
What is the protein family that this protein belongs to?
Belongs to the HSP15 family.
Protein: ILVD_HYDCU
Sequence: MPDYRSKTSTHGRNMAGARALWRATGMKTEDFGKPIIAVANSFTQFVPGHVHLKDMGQLVAGVIEEAGGIAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMCNAHCADALVCISNCDKITPGMMMAAMRLNIPTIFVTGGPMESGKTVLGGMEIKLDLVDAMVMAADDHCSDSDINDVEVSACPTCGSCSGMFTANSMNCLAEALGIALPGNGTTLATHADRRHLFEEAGRRIVELAKLYYEKDDEGVLPRSIATVEAFENAMALDVAMGGSTNTVLHLLAIAREAEVNFTMADMDRISRNVPCLVKVAPNSKDYHMEDVHRAGGIMRILGELDRGELLNRDVKTVHASTMAAAIDLWDITRTDDEAVKTFYRAAPGNVRTTEAFSQNKRWKTLDDDDANGCIRSVEHAYTKEGGLAVLYGNIALDGCIVKTAGVDEEIFKFSGPARIYESQDAAVAAILGDEVKSGDVVLIRYEGPKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHCSPEAAEGGNIGLVEEGDLIKIDIPNRTISVDLTDEELAERRQAMVAKGKAAWKPAEPRTRKVSAALRAYAAMTTSAAFGAVRNVEQIEH
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: BIOD_FRASN
Sequence: MSVLIVTGTGTEVGKTVVTAALAALAADRGTAVAVVKPAQTGVRAGELGDVDLVRDLSGVDDVHELSRYADPLAPVSAARRAGLPTPDLGTVAVAVRRLQADRGLVLVEGAGGLLVRYDHDGSTLADLARTLAAPVLVVTTAGLGTLNATALTLEVMANRGLDLAGIVVGSWPVEPDLAARSNIVDLELLAARPLAGAVPAGAGLLGTGQFLQIARSSLEPALGGAFNAAEFRRRYAV
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.