PharMolix/UniProtQA huggingface dataset:
Protein: TAT_HV196
Sequence: MDPVDPNIEPWNQPGSQPKTACNQCYCKRCCYHCQICFLKKGLGISNGRKKRRPRRTTPYNSENHQDPLRKQPLSQPRGEQTDPKESKKKVESKTKTDQFD
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: SNUFL_HUMAN
Sequence: MEQARDHLHLRWTTEQHMPEVEVQVKYRTAALSNQECQLYLRHSQQQQVLVVDFQAKLRQVFITETPRCGKKPYWNNEEAESKQNPGSIYCLLLLIRGGMSDSLIKREISNFEIVSKNKKN
What are the official names of this protein?
Putative SNURF-like protein.
What is the protein family that this protein belongs to?
Belongs to the SNURF family.
Protein: GLYA_LACAC
Sequence: MKYAEKSPALWDAIRQEEKRQQNTIELIASENIVSDAVREAQGSVLTNKYAEGYPGRRYYGGCQYIDQVEQLAIDYAKKLFNAKFANVQPHSGSQANMAVYQALLKPGDVILGMGMDAGGHLTHGAKVNFSGKEYKSYEYGLNVETEELDFDQIRKVALEVKPKLIVAGASAYSRIIDWQKFRDIADEVGAYLMVDMAHIAGLVATDQHPSPIPVADIVTTTTHKTLRGPRGGMILSNNLEIGKKINSALFPGIQGGPLEHVIAGKAQAFYEDLQPQFTDYIKQVVKNAKAMAEVFDESENIRVVSGGTDNHLMIIDITDTGLTGKDAQNLLDFVNITTNKESIPGDKRSPFITSGLRIGTPAITSRGFNEEDARKTASLIIEILSDPDNEATIEHVKKEVHELTKKHPVE
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG37_BPML5
Sequence: MHVDIYQIAASDTAIYPGAGDCDSIEGLSYVTMGLVGEAGEIANKVKKILRDKDGVITQENRDDLQAELGDVMWYVAQLANQLDVWLSTVTQRNLNKLQSRKDRGVIQGSGDNR
What are the official names of this protein?
Gene 37 protein, Gp37.
Protein: Y1262_RHIEC
Sequence: MNELPFWKSKTLAEMTAAEWESLCDGCGLCCLNKIEEWDSGDVYFTSVSCKLLDGHSCRCSSYETRWDFVPDCVQLTRENVPEIAWLPPTCGYRLINEGRDLYWWHPLVSGDPETVHAAGISARGRTINETEIDIDDLEDYVVDWPLTVGEEKNEEEA
What are the official names of this protein?
UPF0260 protein RHE_CH01262.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: Y3419_BACAC
Sequence: MAKDSSFDIVSKVELPEVTNAINTALKEIQNRYDFKGSKSDIKLEKEVLVLTSDDEFKLEQVKDVLISKLVKRNVPIKNLDYGKVEAAAGNTVRQRATLQQGIDKDNAKKINNIIKEMKLKVKTQVQDDQVRVTAKSRDDLQAVIAAVRSADLPIDVQFINYR
What are the official names of this protein?
UPF0234 protein BAMEG_3419.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: TRUB_ACTSZ
Sequence: MGRRPKKRGRDIHGVFLLDKPPGMSSNDIMQKVKRLFQANKAGHTGALDPLATGMLPICLGEATKFSQFLLDADKRYLVTAKLGERTDTSDAEGQLVQTRAVNVNLTEILTALPHFRGDLMQVPTMFSALKHQGKPLYEYARAGVTVQRQARPITIFELKFIDYNAPFLTLEVHCSKGTYIRTLIDDLGEHLGCGAHVVMLRRTAVSDYPAEKMLTWEALQQLAESADLSRLDALLLPTDSAVSKLPPLVLNEQQTKAVGFGQRIRFNNEENIYGQVRLFSAENLFLGVAEINKDNVIRPTRMVNRNNGTE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: FLIN_CAUVC
Sequence: MAEDNLTLDEFGGAMLASEAPIELSDKTAADLAPVFDVPVNISAVLGRANMSVAQLLQLGQGSILELDRKVGEAIDIYVNNRLVARGEVVVVDERLGVTMTEIIKDGDQG
What is the function of this protein?
FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body.  This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
What are the official names of this protein?
Flagellar motor switch protein FliN.
What is the protein family that this protein belongs to?
Belongs to the FliN/MopA/SpaO family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Protein: INHBA_SHEEP
Sequence: MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALATLPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISQEGSDLSVVERAEIWLFLKVPKANRTRSKVTIRLFQQQKHLQGSLDAGEEAEEVGLKGEKSEMLISEKVVDARKSTWHIFPVSSCIQRLLDQGKSSLDIRIACEQCQETGASLVLLGKKKRKEEEGEGKKRDGEGGAGGDEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFYVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
What is the function of this protein?
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.  Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.  Inhibins appear to oppose the functions of activins.
What are the official names of this protein?
Inhibin beta A chain, Activin beta-A chain.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: OREX_CANLF
Sequence: MNPPSTKVPWAAVTLLLLLLLPPALLSPGAAAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRPGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCPGRRCPVVAVPSAAPGGRSGV
What is the function of this protein?
Binds to orexin receptor HCRTR2/OX2R only (By similarity).  Stimulates food intake (By similarity).  Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity).
What are the official names of this protein?
Hypocretin neuropeptide precursor, Hypocretin, Hcrt, Orexin precursor, Prepro-orexin, Preprohypocretin.
What is the protein family that this protein belongs to?
Belongs to the orexin family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum. Cytoplasmic vesicle. Synapse. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
Protein: DACT1_MOUSE
Sequence: MKPDAAREPEPLSPGRGAEAEGRWRERGEADTERQRTRERQEATLAGLAELGYLRQRQELLVRGALRCSGTVGTVAPRSGELRGDAAQRSRLEEKFLEENILLLRRQLNCLRRRDAGLLNQLQELDKQISDLRLDVEKTSEEHLETDSRPSSGFYELSDGASGSLSNSSNSVFSECLSSCHSSTCFCSPLEAALTISDGCPKSADVNPKYQCDLVSKNGNDVYRYPSPLHAVAVQSPMFLLCLTGNTLREEEGLGSHASDICIGSELNATKTDNSLPSPSSLWSASHPASSKKMDGYILSLVQKKTHPVRTNKPRTSVNADPTKGLLRNGSVCVRAPSGVPPGSSVNFKNTKQMCLPAGGITSLENGPFSPPKQRSKDSKTDQLESKRLALPESCSAGAAMEPQSKHVPKAAKAASQELTRCQAGLGESMKESNQASAVSPKTSPGRGPVAPAESKALQLPKKMSQKNSLQAVPALDRPALDFKSEGSSQSLEEGHLVKAQFIPGQQAAARPHRAHRNPGVARSATLKARGQAAMEHGLPTVREKPRAAGKKCRFPDDSDTNKKFRKTSAKGRRSGGLQDAGLPGRALGTGGHRAGSRAHAHGREPVVAKPKHKRTDYRRWKSSAEVSYEEALRRARRARREHGAAYRVAVALPYASPYAYVPSDSEYSAECESLFHSTVVDTSEDEQSNYTTNCFGDSESSVSEGDFVGESTTTSDSEESGGLIWSQFVQTLPIQTVTAPDLHTRPTKTFVKIKASHNLKKKILRFRSGSLKLMTTV
What is the function of this protein?
Involved in regulation of intracellular signaling pathways during development.  Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.  The activation/inhibition of Wnt signaling may depend on the phosphorylation status.  Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway.  Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity.  Promotes the membrane localization of CTNNB1.  The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB (By similarity).  Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway.  The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling (By similarity).  May be involved in positive regulation of fat cell differentiation.  During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.
What are the official names of this protein?
Dapper homolog 1, Dapper antagonist of catenin 1, Frodo homolog, MDpr1, Thymus-expressed novel gene 3 protein.
What is the protein family that this protein belongs to?
Belongs to the dapper family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Synapse. Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence (By similarity).
Protein: ACP_RHIE6
Sequence: MSDIAERVKKIVIDHLGVDADKVVESASFIDDLGADSLDTVELVMAFEEEFGVEIPDDAADSILTVGDAVKFIEKAQA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4E_METVS
Sequence: MAIKGPRKHLKRLAAPANWQLPRKERTFTVRPSPGPHSMDKSLPLLLIVRDTLKCADNAREAKKIIQMGKILIDGVKRKEYKHPVGLMDVLSIPELNENYLVLFDENGRISLKKTEKTGVKLCKIVNKTVIKGGHIQLNLHDGRNQIVKVANALKAEEDIYKTGDSVLVSLPEQAVVGHVEFNEGKLAYITGGKHVGEFAKVVEVEKRTLYSDIVTLENKDGEKFKTIKPYVFIVGQDEPVISM
What are the official names of this protein?
30S ribosomal protein S4e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: CCSA_EUCGG
Sequence: MIFSTLEHILTHISFSIISIVITIFLISLSVDEIVGLYDSSEKGMTATFFCITGLLVTRWIYSGHFPLSDLYESLIFLSWSFSVIHMVPYFKKHKNYLSTITAPSTIFTQGFATSGLLTEMHQSEIVVPALQSQWLMMHVSMMILGYAALLCGSLLSVALLVITLRKAIRVFSKKNNFLNESFSFVEIQYMNERSNVLLTTSFCSSRNYYRAQLIQQLDQWSYRIISLGFLFLTIGILSGAVWANEAWGSYWNWDPKETWAFITWTLFAIYLHTRTNKNWESFNCAIVASIGFLIIWICYFGVNLLGIGLHSYGSFNLH
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ACCD_ORYSJ
Sequence: MALQSLRGSMRSVVGKRICPLIEYAIFPPLPRIIVYASRRARMQRGNYSLIKKPKKVSTLRQYQSTKSPMYQSLQRICGVREWLNKYCMWKEVDEKDFGFEIGAFD
What is the function of this protein?
This enzyme activity is not detectable in leaves.
What are the official names of this protein?
Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta-like protein.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RL4_SHIF8
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLQKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ERH_BOVIN
Sequence: MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK
What is the function of this protein?
May have a role in the cell cycle.
What are the official names of this protein?
Enhancer of rudimentary homolog.
What is the protein family that this protein belongs to?
Belongs to the E(R) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL33_PSYCK
Sequence: MRDKIKLVSTAGTGYYYTTTKNKRTMPGKMEIKKFDPKVRQHVIFKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: YCIB_ECO57
Sequence: MKQFLDFLPLVVFFAFYKIYDIYAATAALIVATAIVLIYSWVRFRKVEKMALITFVLVVVFGGLTLFFHNDEFIKWKVTVIYALFAGALLVSQWVMKKPLIQRMLGKELTLPQPVWSKLNLAWAVFFILCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGIYIYRHMPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PURNU_HAEIN
Sequence: MQAINPNWNVPKNIHAFTTTREGGVSLAPYLSFNLGDHVGDNKSAVKTNRTLLVEKFGLPQTPIFLTQTHSTRVIQLPYSGQNLEADAVYTNVPNQVCVVMTADCLPVLFTTTSGNEVAATHAGWRGLCDGVLEETVKYFQAKPEDIIAWFGPAIGPKAFQVGIDVVEKFVVVDEKAKLAFQPDAIEEGKYLSNLYQIATQRLNNLGITQIYGGNHCTFNEKEKFFSYRRDNQTGRMASVIWFE
What is the function of this protein?
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine.  Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate.  Also has adenosine deaminase activity.
What are the official names of this protein?
Purine nucleoside phosphorylase HI_0175, Adenosine deaminase HI_0175, S-methyl-5'-thioadenosine phosphorylase HI_0175.
What is the protein family that this protein belongs to?
Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.
Protein: AROC_STAAB
Sequence: MRYLTSGESHGPQLTVIVEGVPANLEVKVEDINREMFKRQGGYGRGRRMQIEKDTVEIVSGVRNGYTLGSPITMVVTNDDFTHWRKIMGAAPISDEERENMKRTITKPRPGHADLVGGMKYNHRDLRNVLERSSARETAARVAVGALCKVLLEQLDIEIYSRVVEIGGIKDKDFYDSETFKANLDRNDVRVIDDGIAQAMRDKIDEAKNDGDSIGGVVQVVVENMPVGVGSYVHYDRKLDGRIAQGVVSINAFKGVSFGEGFKAAEKPGSEIQDEILYNTELGYYRGSNHLGGLEGGMSNGMPIIVNGVMKPIPTLYKPLNSVDINTKEDFKATIERSDSCAVPAASIVCEHVVAFEIAKALLEEFQSNHIEQLKQQIIERRQLNIEF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: YI35_SCHPO
Sequence: MGEVERTRQSSSSLLTFKRKRALEACDSCRKQKTRCLAGSVEDENRACLRCRSLNMDCSLADPNHFIRKVENDNMDAISANINSKLENRLKVLEKAISSITNSPIAGQISLKSEKDVFLQGLLSMDEIELLLEIFIERYGKRWLSVDYSASQYMELLYTKSHLMLATACLIALRHNPSLKARIYTDVLNIVDRLISEELLTTSPSLQFFEAVSMLTLYRPLRLSQKQDLWLLSGFALQHRTLSSTKGWFNGFAGSSATLTYLDIVPARTWNHLCHGHLVMCMGYRRHAMLDENTFDDCRNILTNTKANEFDGNILGMLSVYSMLYRMLRSPTLDLDYAIFQLEEWRKEWCHLWEQPEPQYSRIAYFYSYNVVYEASIQTATDGNDFANIPRYVSMVQSYALKTIDAIFELSAYDMSRCSDHVLFHAGFASASLLRLIYAAKTKEVDTSIVQPKVLNDLVTKIWKWLLVISVDQYHLATKFANYLKEYQKTVNEGTAESTWFKGPLRPVSSTTLQALKPYNLGVATVERG
What are the official names of this protein?
Uncharacterized transcriptional regulatory protein C1399.05c.
What are the subcellular locations of this protein?
Nucleus.
Protein: SNMP1_DROME
Sequence: MQVPRVKLLMGSGAMFVFAIIYGWVIFPKILKFMISKQVTLKPGSDVRELWSNTPFPLHFYIYVFNVTNPDEVSEGAKPRLQEVGPFVFDEWKDKYDLEDDVVEDTVSFTMRNTFIFNPKESLPLTGEEEIILPHPIMLPGGISVQREKAAMMELVSKGLSIVFPDAKAFLKAKFMDLFFRGINVDCSSEEFSAKALCTVFYTGEIKQAKQVNQTHFLFSFMGQANHSDSGRFTVCRGVKNNKKLGKVVKFADEPEQDIWPDGECNTFVGTDSTVFAPGLKKEDGLWAFTPDLCRSLGAYYQHKSSYHGMPSMRYTLDLGDIRADEKLHCFCEDPEDLDTCPPKGTMNLAACVGGPLMASMPHFYLGDPKLVADVDGLNPNEKDHAVYIDFELMSGTPFQAAKRLQFNLDMEPVEGIEPMKNLPKLILPMFWVEEGVQLNKTYTNLVKYTLFLGLKINSVLRWSLITFSLVGLMFSAYLFYHKSDSLDINSILKDNNKVDDVASTKEPLPSANPKQSSTVHPVQLPNTLIPGTNPATNPATHHKMEHRERY
What is the function of this protein?
Plays an olfactory role that is not restricted to pheromone sensitivity.  Has a role in detection and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA).  Not required for sensitivity to general odorants.  Acts in concert with Or67d and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex.  Essential for the electrophysiological responses of these olfactory sensory neurons (OSNs) to cVA.  Not required for the development of trichoid OSNs and support cells.
What are the official names of this protein?
Sensory neuron membrane protein 1, SNMP1Dmel.
What is the protein family that this protein belongs to?
Belongs to the CD36 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NNR_PYRAE
Sequence: MESITSIEMYVADRNAEWLGVPRLVLMENAGAAVARNVLRKFPTAKRILVVCGTGDNGGDGYVAARHLHAAGRTVRVIALGEPREELARINYQAVTRLWGVEVKAAQLPLELLALQDWFMWAEVIVDAVLGTGIRGVLREPHATAIELMNISPAPKVAVDVPSGLDPDTGEVRDKAVRAALTVTFHKAKRGLLAPGAQRYVGELVVEPIGIPPEAELVVGPGDFAYLNFTRRADSKKGDHGRVLVIGGSLEYSGAPVYVALAALRAGVDLAVIAAPEPAAYAAKAISPDIIAIPLEGPRLSTKHVDKLASLAERFNVVAMGPGLGVEEETQEAVRELFRRLAGKRAMVIDADALKALRGVRASGAVVYTPHAGEFKALTGAEPPQSLSERMAVVREQAAALGGVILLKGRYDVISDGVRVKVNMTGTPAMTVGGTGDVLTGLVAAFLTKTSDPLEAAAVAAFVNGLAGEDAAAELGFHITASDLIERLPRVIRRYAFESIR
What is the function of this protein?
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP.  This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).
What are the official names of this protein?
Bifunctional NAD(P)H-hydrate repair enzyme Nnr, Nicotinamide nucleotide repair protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NnrD/CARKD family.
Protein: ISPE_ACIAD
Sequence: MIRVASPAKINLFLHITGRRNDGYHELQSIFQLIDLYDWMTFTPRTEAEDNLSITGIEQVDLEQNLIFRAAQLLKLYAKKYCGLNIQIEKQIPMGAGLGGGSSNAATTLLVLNQLWDCGLNLDQLAALGVKLGADVPIFIYGKNAWAEGIGEKLTFVDLDQKQYIILKPDCFISTQLLFSQKTLTRDSNRTTFCAYQLKPSDFGNNFEALARSLYPEVEEAMQYLDQFGQAKLTGTGACVFTEVTPEMNVSEIVQHAPCKSYVVHSLNKSPLSHFMTDI
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: ATPG_NITWN
Sequence: MASLKDMRVRIASTKATQKITKAMQMVAASKLRRAQNAAEAARPYAEKMDTVISNIASAAAGSPNASPLLAGTGKDQVHLLLVCTGERGLSGAFNSAIVRLARDRAFALMNQGKEVKFFCVGRKGYEQLRRIFEKQIVETVELRTVRQLGFVNAEDIARKVLARFDAGEFDVCTLFYSRFQSVIAQVPTAQQVIPLAVEDAARSDGPAPSYEYEPEEDEILNGLLPRNLAVQIFRALLENNASFYGAQMTAMDNATRNAGEMIRKQTLIYNRTRQAMITKELIEIISGAEAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL34_RHIE6
Sequence: MKRTYQPSKLVRKRRHGFRARMSTKGGRKVIAARRAQGRKRLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: COQ10_YEAST
Sequence: MVLIIRPSQTLILFRKAMLKPIGRYPLKRNFFGLSGTNHTIREQRYVLRKAINAPPSTVYAAVSEVAQYKEFIPYCVDSFVDKRNPVDNKPLIAGLRVGFKQYDEEFICNVTCKDTDHTYTVVAETISHNLFHLLISKWTIMPHPNRPNAAMVELLLRFKFKSRIYNSVSLIFAKTVTELVMNAFAKRAYHLVRLAMLKPSSKEGSP
What is the function of this protein?
Required for the function of coenzyme Q in the respiratory chain.  May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
What are the official names of this protein?
Coenzyme Q-binding protein COQ10, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COQ10 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: PURA_BRUSU
Sequence: MANVVVVGSQWGDEGKGKIVDWLSERADVIVRYQGGHNAGHTLVIDGVSYKLSLLPSGLVRGKLSVIGNGVVVDPHHFVAEVEKLRGQGIDVTPDVLRVAENAPLILSIHRELDAMREGSNSGLKIGTTKRGIGPAYEDKVGRRAIRVIDLTEPETLRPKVERLLAHHNSLRRGMGLEEIAVETILTELTSVADQILPYIDQVWRVLDERRKAGARILFEGAQGALLDNDHGTYPFVTSSNTVAGQAAAGSGLGPTAIGYVLGITKAYTTRVGEGPFPTELNDEIGEFLGTKGHEFGVVTGRKRRCGWFDAVIVRQTVRTSGINGIALTKLDVLDGLEEIKICVAYELDGKRIDYLPSSMGAQARVKPIYETLPGWSETTAGARSWNDLPAQAVKYVRHIEELIGAPVAMLSTSPEREDTILVTDPFHD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.