PharMolix/UniProtQA huggingface dataset:
Protein: AROA_BARHE
Sequence: MQKTIPMTAYKSTRLSGIIKIPGDKSISHRSLILGGLASGETHIHGILESDDVFNTAAAMQALGACIIKKDDLWIIRGTGNGCLLAAQKPLDFGNAGTGARLVMGMVGPYHMKTTFIGDASLSKRPMARILDPLQLMGVEIEATHGNYLPLTLYGPKMTNPICYRIPVASAQVKSAILLAGLNTAGTTTVIEPILTRDHTEKMLKAFGAKLEIEKNAEGTRFIHLNGHPHLTGQTIHIPGDPSSAAFPIVAALLIEDSDITIENVLINNSRMGLIETLWEMGAQIELLNQRQTGGEDVANLRVKSSVLKGVTVPKERAPSMIDEYPALAVAAAFAEGKTVMLGIEELRVKESDRLSVLAQGLKINHVDCEEGQDFLIVHGKGSAKGLGGGHVTTHLDHRIAMSFLIFGLVSEKPVTIDDKRMIATSFPEFIPFIQQLGGKIS
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_MYCS2
Sequence: MTAVASSAPAAPIRVPAGTTAGAAVREADLPGRGAPDAIVVVRDAEGRLRDLSWTPDTDVEVTPVAADTEEGRSVIRHSCAHVLAQAVQELFPQAKLGIGPPITDGFYYDFDVEEPFTPEDLERLEKRMRQIIKDGQLFSRRVYESKDAAREELANEPYKLELVDDKSGDPDVMEVGGDELTAYDNLNARTKERVWGDLCRGPHIPTTRYIPAFKLTRSSAAYWRGDQNNASLQRIYGTAWESQEALDRHLELIEEAQRRDHRKLGVELDLFSFPDELGSGLPVFHPRGGVVRRELEDYSRRKHLEAGYEFVNTPHITKEQLYVTSGHLEWYADGMFPAMHIDAEYDADGQVRKPGQNYYLKPMNCPMHHLIFRSRGRSYRELPLRLFEFGSVYRYEKSGVVHGLTRVRGMTQDDAHIYTTREQMRDELTRLLEFVLSLLKDYGLDDYYLELSTKDPEKYVGSDEIWEEATETLREVAEASGLDLVPDPGGAAFYGPKISVQVKDALGRSWQMSTIQLDFNMPDRFELEYTAADGSRRRPVLIHRALFGSIERFFGVLTEHYAGAFPAWLAPVQVVGIPVADAHTPYLEEVAAQLKSRGVRVEVDSSDDRMAKKIVNHTNMKVPFMLLAGDKDAEAGAVSFRFGDRTQINGVPRDEAVEMIVRWIADRINEVPTAETVKAGAAK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JZ11B_CHIGU
Sequence: MKVSVVITLAVLGVMFVWASAAELEERGSDQRDSPAWLKSMERIFQSEERECRKMFGGCSVDSDCCAHLGCKPTLKYCAWDGTFGK
What is the function of this protein?
This toxin acts as a voltage-dependent gating-modifier (PubMed:25240294).  It inhibits the sodium conductance (IC(50)=124 nM) and slows the fast inactivation (EC(50)=1180 nM) of Nav1. 5/SCN5A (PubMed:17176080, PubMed:25240294).  It significantly shifts the activation to more depolarized voltages and decreases the deactivation of Nav1. 5 currents upon extreme depolarization, but only slightly affects voltage-dependence of steady-state inactivation (PubMed:17176080, PubMed:25240294).  In addition, this toxin causes an approximately five-fold decrease in the rate of recovery from inactivation and an approximately 1. 9-fold reduction in the closed-state inactivation rate (PubMed:25240294).  This toxin integrates the functions of site 3 toxins (alpha-scorpion toxins) with site 4 toxins (beta-scorpion and spider toxins) by targeting multiple sites on Nav1. 5 (PubMed:25240294).  Also shows inhibition of voltage-gated potassium channels (5 uM completely inhibits Kv2. 1/KCNB1, whereas 5 uM moderately inhibits Kv4. 2/KCND2 Kv4. 1/KCND1 channels) (PubMed:17176080).
What are the official names of this protein?
Kappa-theraphotoxin-Cg1a 2, Kappa-TRTX-Cg1a, Jingzhaotoxin-11.2, JZTX-11.2, Jingzhaotoxin-XI.2, JZTX-XI.2, Peptide F4-13.64.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 28 (Jztx-11) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HSLO_NEIG1
Sequence: MNQTAINRADARTRFIFDDMPVRGLHVRLENVWHHIVKQKNYPAAIRCALGELLAAGVLLSGNLKNEGTLIVQVQGQGKLKMLVAEATSDRTVRATARWDETAEIADDESLGDLLGGNGVFVLTLQPKDGEPWQGVVPLEGGSIAQMLVNYMKRSEQLDTHIALSASDEAAGGLLVQRLPEEVLDEEAWEHVSTLARTLTAEELAELDAQHVLYRLFHETPPRVFEPETFESSCTCSRGKVSDMLLMLGGEEVGGVVAEQGSIEVDCDFCHSKYVFDETDVNALFGEDVVGVAKGLPRHTVQ
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU2M_DROYA
Sequence: MFYNSSKILFTTIMIIGTLITVTSNSWLGAWMGLEINLLSFIPLLSDNNNLMSTEASLKYFLTQALASTVLLFSSILLMLANNLNNEINESFTSMIIMSALLLKSGAAPFHFWFPNMMEGLTWMNALMLMTWQKIAPLMLISYLNIKNLLLISVILSVIIGAIGGLNQTSLRKLMAFSSINHLGWMLSSLMISESIWLIYFIFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFSLFMNFLSLGGLPPFLGFLPKWLVIQQLTMCNQYFLLTLMMMSTLITLFFYLRICYSAFMLNYFENNWIMEMNMNSNNTNLYLIMTFFSIFGLFLISLFFFML
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y1772_STAEQ
Sequence: MAMTVKKNDNEVRIQWRVADIKIPNNEIKNVTQDQDIHAVPEENGKEISRIGSTFGKTNRVLIDTDQHLYIIYTQNDQKVYNELTK
What are the official names of this protein?
UPF0457 protein SERP1772.
What is the protein family that this protein belongs to?
Belongs to the UPF0457 family.
Protein: RAPA_AERHH
Sequence: MPFALGQRWISDTETDLGLGTVVAVEGRMVTLLFPATGENRMYAKEEAPVTRVSFNVGDQIASHEDWTMTVEEVQEKDGLLIYVGVRTDNDEPVALKEVFLNNFIKFNKPQDRLFAGQIDRMSRFTLRYEALINQHQRRRNPTRGLAGGRVSLIPHQLYIAHEVGHRYAPRVLLADEVGLGKTIEAGMIIHQQLLSGRAHRVLILLPETLQHQWLVEMLRRFNLHFSLFDEERCIEAFADAENPFETEQLVICSLDFLRKKRRRFEQVLEAEWDLLVVDEAHHLEWSEEAPSRAYEMVEALAEQVPGVLLLTATPDQLGHQSHFARLRLLDPERFYDYDAFLAEEQAYGQVASAAQELLDGETLSDEAKRILASQLEGLDLSDAAARQQAVAKLLDQHGTGRVLFRNSRANIQGFPERHLNVYPMPLPEQYKTAIKVMGMMGGNGGDLQTRALRYLYPEKIFQQFEGDNATWTQFDPRVEWLLELLLSARQQKVLVICSEAATAIALEEALRTREGIRGAVFHEGMSILERDKASAYFAQQEGGAQVLLCSEIGSEGRNFQFASHLVLFDLPLNPDLLEQRIGRLDRIGQQNTVEIHVPYLEGTSQRALQLWYHDGLDAFEQTCPTARPVFEAVRDELFELLAANTGDQAPLDALLVKTRELHEPLKARLEQGRDRLLEIHSSGGAAAQQLVDKLAAEDDDTGMISFALKMFDEIGVNQDDRGENALVLTPGDHMLVSSFPGLPQDGMTITFDRNTALSRDDMALLSWDHPMMRGGIDLILGSEIGATSVALLKNKALPIGSILLELIFVAESAAHPQLYRFMPPTPIRLLMDKNGQNLGEKVAFDAFNRQLTPVNRHLGSKLVTASQPVIHGLIGKGQAIAEELKGGIVDKARAQMAQTLQQDLDRLEALKAVNPNVRDSELDYLRNLQAELHHLIDQTQLKLDAIRFIVVTHN
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: AZOR_RHILW
Sequence: MSSILLLTSSPRAESLSTPIAVELAEKLKNQNPGSFLVRRDLAASPLPHIDDLFTGAIRKPAEARTAEEVAAVKTSDELVNELFAADTIVISTGLINFNIYSSLKTWIDNVARAGLTFKYTESGPVGLLTGKKVYVVLTSGGVYSQGPAAPLNHAVPYLKSVFGFLGITDIETIYVEGLAFGPEAAEKAIDAAKMRVQEIALAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: RS15_THEKO
Sequence: MARIHARKRGKSGSKRPPRTAPPAWVEYTAEEVEALVVKLRKEGYSTAMIGTILRDQYGIPSVKLITGKKITKILEENGLAPEIPEDLMFLIRRAVNLRKHLEQHPKDKHSRRGLQLIESKIRRLVKYYRRTGKLPAKWRYDPEQAKLLVR
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: AXIN2_MOUSE
Sequence: MSSAVLVTLLPDPSSSFREDAPRPPVPGEEGETPPCQPSVGKVQSTKPMPVSSNARRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSVVSKQLKPATKTYIRDGIKKQQIGSVMFDQAQTEIQAVMEENAYQVFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVLCGYLPTLNEEEEWTCADLKCKLSPTVVGLSSKTLRATASVRSTETAENGFRSFKRSDPVNPYHVGSGYVFAPATSANDSELSSDALTDDSMSMTDSSVDGVPPYRMGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPAAFAAELISRLEKLKLELESRHSLEERLQQIREDEEKEGSEQALSSRDGAPVQHPLALLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHQHHHHQQCHTLLPTGGKLPPVAACPLLGGKSFLTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYCYSKCKSHPKAPEPLPGEQFCGSRGGTLPKRNAKGTEPGLALSARDGGMSSAAGAPQLPGEEGDRSQDVWQWMLESERQSKSKPHSAQSIRKSYPLESACAAPGERVSRHHLLGASGHSRSVARAHPFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCCVASQQRDRNHSAAGQAGASPFANPSLAPEDHKEPKKLASVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWDDETVLPMYEGRILGKVERID
What is the function of this protein?
Inhibitor of the Wnt signaling pathway.  Down-regulates beta-catenin.  Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
What are the official names of this protein?
Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_XYLF2
Sequence: MVMTIEALKHLGRVDESRVGRTEPLPLDNRHYVNGHPLCDSFPGLALIQFGLGCFWGAERLFWQLPGVFSTAAGYAGGGVPYPTYREVCSGETGHAEVVLVVYDHTVISFEQLLQTFWESHDPTQGMRQGNDIGTQYRSVIHCTTSEQYAAASASREVYQQQLNTAGYTAITTEILHPAPPFYYAENEHQQYLAKHPNGYCGLGGTGVTCAIRLQV
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: AES_ECOLU
Sequence: MKPEKKLPVLDLISAEMKTVVNTLQPDLPPWPATGTIAEQRQYYTLERRFWNAGAPEMATRAYMVPTKYGQVETRLFCPQPDSPATLFYLHGGGFILGNLDTHDRIMRLLASYSQCTVIGIDYTLSPEARFPQAIEEIVAACCYFHQQAEDYQINMSRIGFAGDSAGAMLALASALWLRDKQIDCGKVAGVLLWYGLYGLRDSVTRRLLGGVWDGLTQQDLQMYEEAYLSNDADRESPYYCLFNNDLTREVPPCFIAGAEFDPLLDDSRLLYQTLAAHQQPCEFKLYPGTLHAFLHYSRMMKTADEALRDGAQFFTAQL
What is the function of this protein?
Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons).  Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate.  Negatively regulates MalT activity by antagonizing maltotriose binding.  Inhibits MelA galactosidase activity.
What are the official names of this protein?
Acetyl esterase.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIP4L_ARATH
Sequence: MRIAEITTPDLRLHHRETDSHTHHPLLSEIELLIQQSEAISKDQPLPQSLPISLRQFLTRLSQLAPFPDNSFKLTIWKLSFRLWNACVDLANAASLQSSLTSAENIANLRHVAADMLFLAKDVTGVPSPTIKSSLFYYKTGLVYHSLKKFDLASDCFERATEIVSKIDIAKISDAGEKKLFLDLNLARSRTAWEISDRNLAVTLLNRAKNLLFGSPDHYKSLSNQFLAFGKSSLSRGDDDCSLNDALRLMNEALDLCEKGLGTAKTREDTTEFTAMRIKTLRFISAVHLQKGEFENVIKCVKVLRNGGNGSDGADQHASLPVLAMKAWLGLGRHSEAEKELRGMVGNNDIPEAVWVSAVEAYFEVVGTAGAETAKGVFLGLLGRCHVSAKAALRVAHRVLGESRGGDNGSRIRANVVAQLVSDERVVALFASEAVTKERKAIHSVLWNSASDHFRAKDYETSAEMFEKSMLYIPHDIENRVFRAKGFRVLCLCYLGLSQLDRALEYIEEAEKLEPNIACSFLKFKIYLQKKEHSCAIGQIDAMTSCLDFSPDYLSLSAHEAISCQALPVAVASLSKFLSFYISGKKMPTTEVVVFRTLVTILTQDIGSETEALNFMLQAQSRASKLGTECFFGLGETGKREQNWFAATCWNLGSRCGKEKKYELCGEFLRLASEFYGYIDTDESGEDKLMICRSIILSVTAMIALEKQTKSALTETQVKLAAELLVRAGKIMSSSLSDGKDCIMEPELIFMYTLLAYDIHGRLNNSAFQLLVVKTFAGSKSCHYNYLLQLGIFASQSPQSNPDVSTFALNECLSALIASASPEYPTIALIIRKLISIASVHKGDTDDEEAILKMYKQAYRIMVGLKEGEYPTEEGKWLAMTAWNRAALPVRLGQFETAKKWLSIGLEIADKVTGMDTYKACMQDYLAGFQTKVSSA
What is the function of this protein?
Required for meiotic chromosome segregation.  It is involved in interference-sensitive crossovers (class I meiotic crossover) formation, in both male and female meiosis.  Is specific to recombination events resulting in interference-sensitive crossovers (class I meiotic crossover).  Not required for synapsis completion.
What are the official names of this protein?
TPR repeat-containing protein ZIP4, Protein SPO22 homolog, AtSPO22, Protein ZIP4 homolog, AtZIP4.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Detected in punctuate foci onto the chromosomes in prophase I meiocytes.
Protein: Y2955_NITOC
Sequence: MPELKTVGLFLITALAEIAGCYLAYLWLREDKTIWLLVPCALSLVAFVWLLSLHPTAAGRVYAAYGGVYIVMAILWLWVVNGIRPTTWDLVGSAIALLGMAIIMFAPRTT
What are the official names of this protein?
UPF0060 membrane protein Noc_2955.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYOD_BUCBP
Sequence: MLKNRYLKYLFILILLSILSIMPIFAIIYRIFSRNYLYAFIIVCLFFQILAHIKFFLNLDFSLEQRWKLISVIFSLVVGLIILLGSIWVIKNLNNNLCIM
What is the function of this protein?
Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E. coli that predominates when cells are grown at high aeration.  Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity).
What are the official names of this protein?
Cytochrome bo(3) ubiquinol oxidase subunit 4, Cytochrome o ubiquinol oxidase subunit 4, Cytochrome o subunit 4, Oxidase bo(3) subunit 4, Ubiquinol oxidase polypeptide IV, Ubiquinol oxidase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase bacterial subunit 4 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL1_LACLM
Sequence: MAKKSKALRAAIEKIDATKAYSVEEAVALAKETSFAKFDATVEVAYNLNIDVKKSDQQIRGAMVLPNGTGKTARVLVFAKGAKAEEATAAGADFVGSDELVAKINGGWLDFDVVIATPDMMAVVGRLGRVLGPRNLMPNPKTGTVTMDVTKAVGESKAGKVNYRADKAGNVHVPIGKVSFDTEKLVENFKALNTVIAAAKPAASKGAYITNLSVTTTMGPGVKVDSASF
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: CDC20_HUMAN
Sequence: MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR
What is the function of this protein?
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex.  Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates.  The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons.  CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
What are the official names of this protein?
Cell division cycle protein 20 homolog, p55CDC.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CDC20/Fizzy family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Protein: ALG14_YARLI
Sequence: MVTTILIAASAILVLLLLRLLFVLPASNRFGFLYRPKHSNPKLMVMMGSGGHTGEMLRMLKTLKLQSYAKRVYVSSSGDVDSLEKVKVLESTTKTDIKTMVLENIPRARKVGQSYPSSVITSAVSFAVAVKLVHKHKPHVIVCNGPATCVMLCYAAFLLRFMALIDTRIIYVESLARVNRLSLSGLILLPFCDRFLVQWPQLAEKYPRAEYHGILV
What is the function of this protein?
Involved in protein N-glycosylation.  Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity).
What are the official names of this protein?
UDP-N-acetylglucosamine transferase subunit ALG14, Asparagine-linked glycosylation protein 14.
What is the protein family that this protein belongs to?
Belongs to the ALG14 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein.
Protein: GTPB6_HUMAN
Sequence: MWALRAAVRPGLRLSRVGRGRSAPRAAAPSCPARALAAVGRRSPGNLEGPWGGGRGLRADGGRSRTGDDEEEPEDADENAEEELLRGEPLLPAGTQRVCLVHPDVKWGPGKSQMTRAEWQVAEATALVHTLDGWSVVQTMVVSTKTPDRKLIFGKGNFEHLTEKIRGSPDITCVFLNVERMAAPTKKELEAAWGVEVFDRFTVVLHIFRCNARTKEARLQVALAEMPLHRSNLKRDVAHLYRGVGSRYIMGSGESFMQLQQRLLREKEAKIRKALDRLRKKRHLLRRQRTRREFPVISVVGYTNCGKTTLIKALTGDAAIQPRDQLFATLDVTAHAGTLPSRMTVLYVDTIGFLSQLPHGLIESFSATLEDVAHSDLILHVRDVSHPEAELQKCSVLSTLRGLQLPAPLLDSMVEVHNKVDLVPGYSPTEPNVVPVSALRGHGLQELKAELDAAVLKATGRQILTLRVRLAGAQLSWLYKEATVQEVDVIPEDGAADVRVIISNSAYGKFRKLFPG
What are the official names of this protein?
Putative GTP-binding protein 6, Pseudoautosomal GTP-binding protein-like.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
Protein: RUVA_VIBCM
Sequence: MIGRLRGTLIEKLPPQILIEVGGIGYEVQMPMSCIYELPNIGEEAIIYTHFVVREDAQLLYGFNTVSERALFREVIKANGVGPKMGLAILSGMTANQFVTCVEKEDISTLIKLPGVGKKTAERLVVEMKDRLKGWGAGDLFTPATDAAPVDSTPVIAQNAQEEAMSALLALGYKPPQASKAVSQVAKAGMSSEELIREALKSMV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: AROE_SYNFM
Sequence: MIKPVQTELYAVIGNPVAHSLSPVMMNAAFRSMNVPATYLALQADELPEDLETLARFGFRGLSVTLPHKELAYRLADHVDDMARTIGAVNTLMREGSAWIGCNTDWLGATKALRRVTELEGREALILGAGGAARAVAFGMKREGARVTIANRCVEKGKALAKSFRCDFIPLAILDRARFDRHFDVVVQCTSVGLQGTIPTVLVSDSFFEPGMVVMETVYRPLRTPFLNAAKRAGATIVHGTDMLVYQGVAQLEWWLSRPIPEFPCVAAMKQAIHEVLSKEKNAQDD
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: DPOL_DHBVQ
Sequence: MPQPLKQSLDQSKRLREAEKHLRELENLVDSNLEEEKLKPQLSMGEDVQSPGKGEPLHPNVRAPLSHVVRAATIDLPRLGNKLPAKHHLGKLSGLYQMKGCTFNPEWKVPDISDTHFDLQVVNECPSRNWKYLTPAKFWPKSISYFPVQAGVKAKYPDNVMQHEAIVGKYLNRLYEAGILYKRISKHLVTFKGKPYNWELQYLVKQHQVPDGTTTSKINGRAENRRRRAPAKSISRPHDSERDCNMVGQISNNRSSIRPCANNGGGKHSSTTGRLACWGGKTIGTDQSYSSRDASASVDSRGRSKSSRGFSSISRRKATGNHHHCSYVTNSVEATTRGRSTPGKQVFTRDSSSLPESRASRACDKDSSPQEEENAWYLRGNTSWPNRITGKLFLVDKNSRNTTEARLVVDFSQFSKGKNAMRFPRYWSPNLSTLRRILPVGMPRISLDLSQAFYHLPLNPASSSRLAVSDGQHVYYFRKAPMGVGLSPFLLHLFTTALGSEIARRFNVWTFTYMDDFLLCHPNARHLNSISHAVCSFLQELGIRINFDKTTPSPVNDIRFLGYQIDQKFMKIEESRWIELRTVIKKIKIGAWYDWKCIQRFVGHLNFVLPFTKGNIEMLKPMYAAITNKVNFSFSSAYRTLLYKLTMGVCKLAIRPKSSVPLPRVATDATPTHGAISHITGGSAVFAFSKVRDIHIQELLMVCLAKIMIKPRCILSDSTFVCHKRYQTLPWHFAMLAKQLLSPIQLYFVPSKYNPADGPSRHRPPDWTALTYTPLSKAIYIPHRLCGT
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery (By similarity).
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: FAM3A_PONAB
Sequence: MRLAGPLRIVALVVSVGLTWIVVSILLGGPGSGFPRIQQLFTSPESSVTAAPRARKYKCGLPQPCPEEHLAFRVVSGAANVIGPKICLEDKMLMSSVKDNVGRGLNIALVNGVSGELIEARAFDMWAGDVNDLLKFIRPLHEGTLVFVASYDDPATKMNEETRKLFSELGSRNAKELAFRDSWVFVGAKGVQNKSPFEQHVKNSKHTNKYEGWPEALEMEGCIPRRSTAS
What are the official names of this protein?
Protein FAM3A.
What is the protein family that this protein belongs to?
Belongs to the FAM3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LYSX_SACS2
Sequence: MPRWEEKNLIEEGKKLGYQVATIYSKDFVLFSNDFTIDNDTDLFIQRNVSHNRALITSFLVEQVGYPVINDHTTLIRCENKIFTTYILARHNIPTPKTFIAFDKTNAIEYSKKLGYPVVIKPVEGSWGRMVAKADNLDVLYSYLEYQEFSTQKYKDIYYIQEFVNKPNRDIRIFVIGDETPVGIYRVNENNWRTNTALGAKAYPLKIDEELRELALKVKDIIGGFFLGIDIFEDKDRGYLVDEVNGVPEYKNTVRVNNFNVSKFLLEKAAEWVKK
What is the function of this protein?
Catalyzes the ATP-dependent formation of a covalent bond between the amino group of alpha-aminoadipate (AAA) and the gamma-carboxyl group of the C-terminal glutamate residue in LysW.
What are the official names of this protein?
Alpha-aminoadipate--LysW ligase LysX, AAA--LysW ligase LysX.
What is the protein family that this protein belongs to?
Belongs to the RimK family. LysX subfamily.
Protein: DGTL1_SHEB8
Sequence: MTSSVWQERRHGEDKQRRNDHRSPYQRDRARILHSAAFRRLQAKTQVLGVGMNDFYRTRLTHSLEVSQIGTGIAAQLRRKYPQHKQLLCSMSLLESLCLAHDIGHPPFGHGGEVALNYMMRDHGGFEGNGQTFRILSKLEPYTLDFGMNLCRRTMLGILKYPAPHSKLFVAGKHSEITNHRQLKPSQWPPVKGIFDDDNDIFAWVLEPLSEADRSRFTSTQQGSHPALHHYPHLRTQFKSFDCSIMELADDIAYAVHDLEDAIVMGIVTASQWHQDVAPTLTNSGDAWIRQELADIGNKLFSHEHHLRKDAIGTLVNGFVTAIVISEDDVFEEPLLRFNATLEPEFAIALNVLKQLVYKYVIRKPEIQMLEYKGQQIVMGLFEAFASDPERLLPLNTQERWRESEQQGLNSHRVLADYISGMTDEFAGRLYQQLFSPKAGSNVELSKEM
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.