PharMolix/UniProtQA huggingface dataset:
Protein: HYPA_PROA2
Sequence: MHEMSIALSVVDAITARAREEQAEKVTAIELVAGKLSGVEIESLKFCFSAAVRGTIMEDAELMVTVPLSEGLCEVCGERFAVDGYYTQCPSCGSYKVRIVSGKELSIRSITLE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: FB152_ARATH
Sequence: MMTLQSSPMSVLTEDLVEDILSRVPATSLVRLRSTCKQWNAILNDRRFIKKHFDTAEKEYLDMLLRSLRVSSMSVNLHGLHDNIDPSIELKRELNLKGLLCNSGKVESFEVFHCNGLLLFTNTSTIVVWNPCTGQTKWIQTESANTRYHKYALGYENKNLCRDYKILRFLDDGTNFELEIYEFNSSSWRVLDSVEIDFELDIGSQGMSVKGNTYWIVIDDHEVDGELVNCFLTSFDFTRERFGPHVCLPFQTSWYSDVISLSSVREERLSVLFHEEDSLTMEIWVTNDITDTIVTSWSKFLRVDLYTHRFYNGVTFFIDEENKAAVFSEDVPDDSDDIHSIVYIIGQDRLRIVDLEDGPFWPQMFCYVPSLVQI
What are the official names of this protein?
Putative F-box protein At3g17480.
Protein: SPE1_ARATH
Sequence: MPALAFVDTPIDTFSSIFTPSSVSTAVVDGSCHWSPSLSSSLYRIDGWGAPYFAANSSGNISVRPHGSNTLPHQDIDLMKVVKKVTDPSGLGLQLPLIVRFPDVLKNRLECLQSAFDYAIQSQGYDSHYQGVYPVKCNQDRFIIEDIVEFGSGFRFGLEAGSKPEILLAMSCLCKGNPEAFLVCNGFKDSEYISLALFGRKLELNTVIVLEQEEELDLVIDLSQKMNVRPVIGLRAKLRTKHSGHFGSTSGEKGKFGLTTVQILRVVRKLSQVGMLDCLQLLHFHIGSQIPSTALLSDGVAEAAQLYCELVRLGAHMKVIDIGGGLGIDYDGSKSGESDLSVAYSLEEYAAAVVASVRFVCDQKSVKHPVICSESGRAIVSHHSVLIFEAVSAGQQHETPTDHQFMLEGYSEEVRGDYENLYGAAMRGDRESCLLYVDQLKQRCVEGFKEGSLGIEQLAGVDGLCEWVIKAIGASDPVLTYHVNLSVFTSIPDFWGIDQLFPIVPIHKLDQRPAARGILSDLTCDSDGKINKFIGGESSLPLHEMDNNGCSGGRYYLGMFLGGAYEEALGGVHNLFGGPSVVRVLQSDGPHGFAVTRAVMGQSSADVLRAMQHEPELMFQTLKHRAEEPRNNNNKACGDKGNDKLVVASCLAKSFNNMPYLSMETSTNALTAAVNNLGVYYCDEAAAGGGGKGKDENWSYFG
What is the function of this protein?
Required for the biosynthesis of putrescine.  Catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine from arginine (PubMed:11576438, PubMed:15733873, PubMed:25409942).  Is a minor contributor to basal arginine decarboxylase (ADC) activity and putrescine biosynthesis (PubMed:25409942).  Accumulation of putrescine plays a positive role in freezing tolerance (PubMed:18701673).  Production of polyamines is essential for normal seed development (PubMed:15733873).  Controls PA homeostasis which is crucial for normal plant growth and development (PubMed:27014322).
What are the official names of this protein?
Arginine decarboxylase 1, chloroplastic, ADC 1, ADC-O, ARGDC 1, AtADC1.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast. Cytoplasm, cytosol. Note=Localizes mainly in the chloroplast.
Protein: DDL_GLAP5
Sequence: MSLKNEKIAVLFGGVSAEREISLNSGKSVFEALQSLGYNVEAIDTKEFPIEKLKEKGIQRVFNILHGGIGENGVLQGALEQLGIPYTGCGVMASAITLDKFRTKLLWNAVGLPTAAMEVVRRGQAVNSDEIIAKLGLPLFVKPASEGSSVGVSKVKTAEQLLPAIEEALKYDSIVLVEENLAGAEYSVPVLDGEVLPAVQIIPDGEFYDYHAKYISDNTQYVVPALNADRQAEVAKLVKQAYDVVGCRGWSRIDVMEDGEGNFRLVEVNTCPGMTSHSIFPKSAATVGYSFERLVERVLELSA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANE_STRU0
Sequence: MPDRISKETFLTNIKDGIIVSCQALPGEPLYSPEGGVMPLMAKAAEEAGAVGIRANSVRDIKEIQAVTDLPIIGIIKKDYPPQEPFITATMAEVDQLAELGIAVIALDCTKRQRYDGRPIEDFIREIKRKYPNQLFMADISTFEEGLKAFEAGIDFVGTTLSGYTSYSRQQEGPDMTLIAELCQEGIPVIAEGRIHTPEQARQINELGVAGIVIGGAITRPKEIAARFIKALKD
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: AROA_JANSC
Sequence: MSAHGDPKPMTARKGGALTGTAEVPGDKSISHRSLIFGAMAVGETRVTGLLEGQDVLDTASAMRAFGAEVAREDDGTWSIHGVGVGGFVEPDDVLDCGNSGTGVRLLMGAMATTPISVTFTGDASLRSRPMARVTDPLALFGTRAYGRAQGRLPMTLVGAEAPMPVRYATPVPSAQVKSAVLLAGLNAPGETVVIEAEATRDHSERMLAGFGAQISTEVTQEGRVITLTGQPELTPQVIAVPRDPSSAAFPVCAAIITEGSDVLVPNIGLNPTRAGLFETLRDMGADLTYENPREEGGEPVADLRAKFSPDMKGIEVPPERAASMIDEYPILSVVAANAEGTTVMRGVKELRVKESDRIAAMADGLRLNGIEVEDGPDWWIVHGRGPGGMAGGATVATHLDHRIAMSFLCAGFASQQGITIDDSGPIATSFPIFEPLMRDLGARLDRANA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSPB1_RAT
Sequence: MTERRVPFSLLRSPSWEPFRDWYPAHSRLFDQAFGVPRFPDEWSQWFSSAGWPGYVRPLPAATAEGPAAVTLARPAFSRALNRQLSSGVSEIRQTADRWRVSLDVNHFAPEELTVKTKEGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTLVSSSLSPEGTLTVEAPLPKAVTQSAEITIPVTFEARAQIGGPESEQSGAK
What is the function of this protein?
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state.  Plays a role in stress resistance and actin organization.  Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.
What are the official names of this protein?
Heat shock protein beta-1, HspB1, Heat shock 27 kDa protein, HSP 27.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein: CTK2_XENLA
Sequence: MDSTDKKVQVASRLPVPPKRKYVSNDENQEQMQRKRLRSSLESELPAVRVAASIATSKPRAAPVAALPKPQVIGRQSLAVMRPKNSGPGITSTSFSGKTKVSSSVTQPAAIGAEKKKRAAWDLKGQVNDMRDTVSNYKGKMQNLTGENARLLNSKEKLQREVEVLASENSKLSQERCTLESQLREVRQQVSTFEREVARLTELCQRQEKELSSHTNTIEELQGANAILTKQLLDKEVKLDCVSGENTSLKHTVNEQTDEIAALKVCLAEKDTEVHSLDTERRRLHNLVQELKGNIRVFCRVRPTLTPERELPAGHISFPSNDGKAIVLSKMEESHIGREKKDAVKYDFNFDCVFPPPCSQESVFEEISLLVQSALDGYPVCIFAYGQTGSGKTYTMEGPEDVTDDSMGMIPRAIHQIFSSAEELKAKGWQYTFTASFLEIYNETIRDLLINRPDKKLEYEIRKVNSANMLLYVTNLRYVKVSCVEEVHELLKIAKANRSVAKTAINDRSSRSHSVFQLKIEGENKQRDLKTSSMISLIDLAGSERLDRSLSTGDRLKETQCINTSLSTLGMVITSLCNKDSHIPYRNSKLTYLLQNSLGGNAKVLMFVNISPLEENFAESLNSLRFASKVNECVIGTARANRK
What is the function of this protein?
Promotes mitotic spindle assembly.
What are the official names of this protein?
Carboxy-terminal kinesin 2, XCTK2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TORS_ECO57
Sequence: MNLTLTRRLWMGFALMALLTLTSTLVGWYNLRFISQVEKDNTQALIPTMNMARQLSEASAWELFAAQNLTSADNEKMWQAQGRMLTAQSLKINALLQALREQGFDTTAIEQQEQEISRSLRQQGELVGRRLQLRQQQQRLSQQIVAAADEIARLAQGQANNAATSAGATQAGIYDLIEQDQRQAAESALDRLIDIDLEYVNQMNELRLSALRVQQMVMNLGLEQIQKNAPTLEKQLNNAVKILQRRQIRIEDPGVRAQVATTLTTVSQYSDLLALFQQDSEISNHLQTLAQNNIAQFAQFSSEVSQLVDTIELRNQHGLAHLEKASARGQYSLLLLGMVSLCALILILWRVVYRSVTRPLAEQTQALQRLLDGDIDSPFPETAGVRELDTIGRLMDAFRSSVHALNRHREQLAAQVKARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATAIADDVPTALMGDPRRIRQVITNLLSNALRFTDEGQIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFIQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATAPVPKTVNQAVRLDGLRLLLIEDNPLTQRITVEMLNTSGAQVVAIGNAAQALETLQNSEPFAAALVDFDLPDVNGITLARQLARQYPSLVLIGFSAHVIDETLRQRTSSLFRGIIPKPVPREVLGQLLAHYLQLQANNDLPLDVSQLNEDAQLMGTEKIHEWLALFTQHALPLLDEIDIARATQDSEKIKRAAHQLKSSCSSLGMRSASQLCAQLEQQPLSAPLPHEEITRSVAALEAWLNKKDLNAI
What is the function of this protein?
Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO).  Detects the presence of TMAO in the medium and, in response, activates TorR via a four-step phosphorelay.  When TMAO is removed, TorS can dephosphorylate TorR, probably by a reverse phosphorelay involving His-860 and Asp-733 (By similarity).
What are the official names of this protein?
Sensor protein TorS.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FHY1C_ARATH
Sequence: MAAAAMHTSAEFINLKPNMWKKNPVRASGSCCLGSSSGDEISRKRKLPILLFDVMDTIVRDPFYQDVPAFFGMPMKQLLECKHPMVWIEFEKGLIDEEELARNFFIDGRDFDLEGLKECMRSGYSYLDGMQELLQTLAADDFEIHAFTNYPIWYNIIEDKLKLSAYLSWTFCSCIAGKRKPDPEFYLEVVGHLGVEPCDCIFIDDRPTNVKCAIEIGMGGLCFENADSLAKDLSDLGINVSVPKL
What is the function of this protein?
FMN hydrolase that catalyzes the dephosphorylation of flavin mononucleotide (FMN) to riboflavin (PubMed:22002057, PubMed:24123841, PubMed:27490826).  Can also dephosphorylate 5-amino-6-(5-phospho-D-ribitylamino)uracil, also known as ARPP (PubMed:24123841, PubMed:27490826).  Not required for riboflavin biosynthesis in planta, but may help maintaining flavin homeostasis within chloroplasts (PubMed:27490826).
What are the official names of this protein?
Flavin mononucleotide hydrolase 1, chloroplatic, AtcpFHy1, 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase, AtcpFHy1/PyrP1, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate phosphatase, ARPP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: VGLL3_HUMAN
Sequence: MSCAEVMYHPQPYGASQYLPNPMAATTCPTAYYQPAPQPGQQKKLAVFSKMQDSLEVTLPSKQEEEDEEEEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVVDEHFSRALGQAITLHPESAISKSKMGLTPLWRDSSALSSQRNSFPTSFWTSSYQPPPAPCLGGVHPDFQVTGPPGTFSAADPSPWPGHNLHQTGPAPPPAVSESWPYPLTSQVSPSYSHMHDVYMRHHHPHAHMHHRHRHHHHHHHPPAGSALDPSYGPLLMPSVHAARIPAPQCDITKTEPTTVTSATSAWAGAFHGTVDIVPSVGFDTGLQHQDKSKESPWY
What is the function of this protein?
May act as a specific coactivator for the mammalian TEFs.
What are the official names of this protein?
Transcription cofactor vestigial-like protein 3, Vgl-3.
What is the protein family that this protein belongs to?
Belongs to the vestigial family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SELU_PHOPR
Sequence: MLMPRQNCEVFRQLFVNDTPLMDMRAPIEFAQGAFPTSINHPLMEDEERKAVGTCYKAHGQDAAIALGHQLVNGDIKAARLAQWKAFAEENPNGYLYCFRGGLRSRITQQWLKEAGIDYPMVVGGYKALRRFLIETIDTVAQQPMTIVGGNTGSGKTIMVNELANGIDLEGAANHRGSSFGRYVTAQRTQIDFENVLAVEMLKKQAQGCTHFVFEDEGRAIGSASVPLSINAAMGNADVAIVDDPLDVRIDRLIDDYVVRMQRDYIAQNGEQQGWELFTEYLERGMFGIRKRLGMKRYEELLAAQKQAIATQKSNGTLAEHDNWLRPLLIEYYDPMYTYQLSKKADRIVFRGNYQEVKSWLADK
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: ZFP90_MOUSE
Sequence: MAPRPPTAKPQESVTFKDVAVNFTQEEWHHVGPAQRSLYRDVMLENYNHLVSLGYQVSKPEVIFKLEQGEEPWISEKEIQRPFCPDWKTRPESSRSPQQGVSEVFLRTNVLSHTTIGDIWNVAIQGHQESGRRHLGPEASSQKKITTLEKKIEQNKVGEDSSLSTDLVPQLDISSSIRPSDCKTFGNNLEHNSELVTQSNILAKKKPYKCDKCRKSFIHRSSLNKHEKIHKGDPYSNGTDQGAQSGRKHHECADCGKTFLWRTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLTQHEVTHSGEKPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRSKPYQSNNFSLAFVPNTPLPQGEGLLTEVKSYHCNDCGKDFGHITDFSEHQRLHAGENSYGSEQTLLGQQSLSHPREKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRLSSLTQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECNECGRAFRKKTNLHDHQRTHTGEKPYACKECGRNFSRSSALTKHHRVHARNKLQES
What is the function of this protein?
Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.
What are the official names of this protein?
Zinc finger protein 90, Zfp-90, Zinc finger protein NK10.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with REST in the nucleus.
Protein: GRDH_ORYSJ
Sequence: MASQQFPPQNQETQPGKEHAMDPRPEAIIQSYKPANKLKDKVAIVTGGDSGIGRAVCLCFALEGATVAFTYVKGQEEKDAEETLRALRDIRARTGAKDPMAIPADLGYDDNCRKVVDEVAGAYGGAIDILVNNAAEQYERPSITDITEDDLERVFRTNIFSYFFMSKHAVKRMRDRRGGAGAGGCSIINTSSINAYKGNKTLLDYTATKGAIVAFTRALALQLAEEGIRVNGVAPGPIWTPLIPASFAEEKVRQFGSQVPMGRAGQPSEVAPSFVFLASDDASYMSGQMLHVNGGVIVNG
What is the function of this protein?
May act as a short alcohol-polyol-sugar dehydrogenase possibly related to carbohydrate metabolism and the acquisition of desiccation tolerance.  May also be involved in signal transduction (By similarity).
What are the official names of this protein?
Glucose and ribitol dehydrogenase homolog.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: SELO_RHOJR
Sequence: MRGGPCGGYPRRMTAIPDSTVGTNTAVAGLESTFADELGALTVPWQGAHAPDPTLLVLNEQLAASLRLDVQTLRSEDGVGVLSGSTAPAGAKPVAMAYAGHQFGGYAPLLGDGRALLLGELTSSDGQRVDLHLKGSGPTPFSRGGDGFAVIGPMLREYLVSEAMYALGIPTTRALSVVATGQNVHRYGAEPGAVLARVAASHLRVGTFEYAVRQGEVLQPLADYAIARHYPELTELPPGRDGNRYLSFFEAVVEAQASLVAKWMLTGFVHGVMNTDNTTISGETIDYGPCAFLDAFDPAAVFSSIDHGGRYAFGNQPVVLKWNLARLAETLLTLFDSTPDDAITAVSAVLATFDERYDGHYAAGMAAKLGLAGELVDRALVDDLLTLLEEHGADWTGTFRALADELRGHSTPLDGLVPREHIGPWLERWRGDLTKHGRGAAETADAMDCVNPLYIPRNHQLDAALRAATDGRLAPFEKLLEVVTHPFDRRDEWSDYTTPAPPSFSKSFQTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: SYS_KOCRD
Sequence: MIDINELRADPDTYRASQTARGADAGLVDRILEADSRRRSAITDFESLRAEQNAFGKKVARAQGEEKQQLLAQVKQLAADVKAAQAAADEAQATQQQLVTQFPNLIVEGIPAGGEDDFVQLRTEGTPRDFAAEGFEPRDHLELGELLDGIDMERGAKVSGSRFYFLKRDVARLETALLMAAQDLALDNGFIPMTTPNLVRPGIMNGTGFDVEHDDEIYRVGKDDLYLVGTSEVALAGYHSDEILDLSGGPLRYAGWSSCYRREAGSAGKDTRGIIRVHQFNKLEMFVYCHPEDAAAEHERLLAWEEQMLQACGLAYRVIDTAAGDLGTSAARKFDCEAWIPTQGKYRELTSTSNCTTYQARRLNIRERLPETTDAHGKVKKGGTRAVATLNGTLATTRWLVALLETHQQADGSVTVPELLRPYLRGQEVLRPVA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_BACLD
Sequence: MRYLTAGESHGPQLTTIIEGVPAGLYITKEDIDYELQRRQKGHGRGRRMQIEKDQARITSGVRHGRSLGSPIALVVENNDWKHWTKIMGSEPITAEEESEMKRQISRPRPGHADLNGAIKYGHRDMRNVLERSSARETTVRVAAGAVAKKILSQLGIQVAGHVLEIGGVKAEKTNYESIENLKKVTEESPVRCYDEEAGRKMMDAIDEAKANGDSIGGIVEVIVEGVPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAARKNGSEVHDEIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFTASIERSDSCAVPAASVVAEAVVAWEIANAIVEQFGVDQMDRIAENVEKMRKLAREF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: AROE_BACSU
Sequence: MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDLEDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTDGEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRLTEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCDIVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLGGTEC
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: UVRA_LISMO
Sequence: MDKEKIVIQGARAHNLKNIDVEIPRDKLVVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDLIEGLSPAISIDQKTTSRNPRSTVGTVTEIHDYLRLLYARVGHPVCPNHGIEITSQTIEQMVDRVLEYPEKTRIQIMAPIVSGKKGTHKKTIEEIKKEGYVRIRVDGEIYDINDEIEIEKNKKHSIEIIIDRIVIKEGINTRLYDSIEAALRLADGYAVVDIMGDKELLFSEHYACPYCGFSVGELEPRMFSFNSPFGACPTCDGLGTKLEVDVDTVIPDRSMSLNEGAIIPWRPISSQYYPQMLASACKEFGIDMDTPLEKLSKEELDIILNGSKDKEFYFEYKNDFGMTRETWIPFEGILPNIERRYRETNSDFTRDQMAQYMTDLPCPSCKGYRLKEETLSVKVNDHHIGQISEFSINEALAFFDGLELSEKETQIAAPIFKEVRARLGFLKNVGLDYLTMSRAAGTLSGGEAQRIRLATQIGSRLTGVLYILDEPSIGLHQRDNDRLISTLQSMRDIGNTLIVVEHDEDTMMAADYLIDIGPGAGEHGGRIVAAGTPEEVANNKNSITGDYLSGKKFIPVPAKRRKGNGLELEIIGAKANNLKNVNAKIPLATFSCVTGVSGSGKSSLVNEVLRKALARKLNRNHAKPGEHKEIKGIENLEKIINIDQSPIGRTPRSNPATYTGAFDDIRDLFASTNEAKVRGYKKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCHGKRYNGETLDIRYKGKNIAEVLEMTVEEGLEYFTNQPRIARKLQTIVDVGLGYIRLGQPATTLSGGEAQRVKLASELHKRSNGKSFYILDEPTTGLHADDIGRLLKVLQRLVEENGDTVLVIEHNLDVIKQADYLIDLGPEGGDGGGQIIATGTPEKIARSKKSYTGKYLKPILERDKERTEERIATAKKK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrA is an ATPase and a DNA-binding protein.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
What are the official names of this protein?
UvrABC system protein A, UvrA protein, Excinuclease ABC subunit A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. UvrA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXOS5_MOUSE
Sequence: MEGAKRADANLLTDTGTESSPRSPVCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLVRNTCEAVVLGALHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVTCALDSDGNLVLDPTTKQEKEARAILTFALDSAEQKLLMSTTKGLYSDAELQQCLAAAQAASQHIFRFYRESLQRRYSKS
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  It seems to be involved in degradation of histone mRNA.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity).
What are the official names of this protein?
Exosome complex component RRP46, Exosome component 5, Ribosomal RNA-processing protein 46.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Nucleus.
Protein: ARG56_YEAST
Sequence: MPSASLLVSTKRLNASKFQKFVSSLNKSTIAGFASVPLRAPPSVAFTRKKVGYSKRYVSSTNGFSATRSTVIQLLNNISTKREVEQYLKYFTSVSQQQFAVIKVGGAIISDNLHELASCLAFLYHVGLYPIVLHGTGPQVNGRLEAQGIEPDYIDGIRITDEHTMAVVRKCFLEQNLKLVTALEQLGVRARPITSGVFTADYLDKDKYKLVGNIKSVTKEPIEASIKAGALPILTSLAETASGQMLNVNADVAAGELARVFEPLKIVYLNEKGGIINGSTGEKISMINLDEEYDDLMKQSWVKYGTKLKIREIKELLDYLPRSSSVAIINVQDLQKELFTDSGAGTMIRRGYKLVKRSSIGEFPSADALRKALQRDAGISSGKESVASYLRYLENSDFVSYADEPLEAVAIVKKDTNVPTLDKFVCSDAAWLNNVTDNVFNVLRRDFPALQWVVSENDANIAWHFDKSQGSYLKGGKVLFWYGIDDINTISELVENFVKSCDTASTLNSSASSGVFANKKSARSYSTRSTPRPEGVNTNPGRVALIGARGYTGKNLVSLINGHPYLEVAHVSSRELKGQKLQDYTKSEIIYESLQIQDIRKLEEQNAVDFWVMALPNKVCEPFVETIQSVHGKSKIIDLSADHRFVSESDWAYGLPELNDRAKIANAAKIANPGCYATGSQLTISPLTKYINGLPTVFGVSGYSGAGTKPSPKNDPKFLNNNLIPYALSDHIHEREISARIGHNVAFMPHVGQWFQGISLTVSIPIKKGSLSIDEIRKLYRNFYEDEKLVHVIDDIPLVKDIEGTHGVVIGGFKLNDAEDRVVVCATIDNLLKGAATQCLQNINLAMGYGEYAGIPENKIIGV
What are the official names of this protein?
Protein ARG5,6, mitochondrial.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAGSA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DNAJ_LACDB
Sequence: MAANRDYYDVLGVSRDASDAEISKAYRKLAKKYHPDLNHEAGAEEKYKEVNEAYEVLHDPQKRQQYDQFGQAGMNGQGGFGGQYGGQGFGGADFGDFGDIFSSFFGGARQQVDPTAPQRGADLDYTMTIDFMDAIKGKTSEISYSRSTTCEVCKGSGAEKGTHPITCDKCGGSGMMTITQRSVLGMIQRQTTCDKCAGSGVIIQHPCHNCHGKGVKTQKQTLQVKVPAGIDNGQQIRLAGQGEAGKNGGPYGDLYIVFRVRPSKDFTRRGQTIYTTVPISFAQATLGDEINVKTVYGDTKLKIPAGTQPNQKFTLKEKGVPSLRGGSTGDQVTTVEIVIPKSINEAQRKALLEFVKASGGSIAPQEKGFFERLKEKLS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.