PharMolix/UniProtQA huggingface dataset:
Protein: GLYC_TAMVU
Sequence: MGQLISFFGEIPTILQEALNIALIAVSIIATIKGVVNVWKSGLIQLLMFVMLAGRSCSVQIGHHLELEHIILNSSSILPFTPTLCKLNKTYFLVRGPFQAHWGVDLAIGSTTVAVENATKTYTLKSKNFTGCFEGNPDPDSAALLVTWLFNSLHHDYKNDPSILCERVSGENSFRFQINISEPEYCEKILSRMANLFGSFENYCLNNRHIKKLIIIRNLTWSQQCHENHMSAMQLITSNIHTQVVRARRILSFFTWSLSDAVGNDMPGGYCLEKWMLIASQLKCFGNTAVAKCNLNHDSEFCDMLRLFDFNRKAIETLQNKTRSQLNIAINAINSLISDNLLMKNRVKELMDIPFCNYTKFWYVNHTKLNHHSLPRCWLVKNGSYLNESEFRNDWLLESDHLISEILSREYEERQGRTPLSLVDVCFWSTLFYTASIFLHLIRIPTHRHIVGEGCPKPHRLRADSTCACGLYKQKRRPLKWVRSN
What is the function of this protein?
Forms the virion spikes together with glycoprotein G1.  The glycoprotein spike trimers are connected to the underlying matrix.  Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm.  Membrane fusion is mediated by irreversible conformational changes induced by acidification.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: RS21_HALH5
Sequence: MAETRVRKNESIDAALRRFKRSLSKEGTLAEVRKRKHYEKPSVRRKKKSEAARKRKF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: HIS5_STAAC
Sequence: MIVIVDYGLGNISNVKRAIEHLGYEVVVSNTSKIIDQAETIILPGVGHFKDAMSEIKRLNLNAILAKNTDKKMIGICLGMQLMYEHSDEGDASGLGFIPGNISRIQTEYPVPHLGWNNLVSKHPMLNQDVYFVHSYQAPMSENVIAYAQYGADIPAIVQFNNYIGIQFHPEKSGTYGLQILRQAIQGGFIND
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYSJ_THET8
Sequence: METRTLEDWRALLEAEKTLDSGVYNKHDLLIVRGQGARVWDAEGNEYIDCVGGYGVANLGHGNPEVVEAVKRQAETLMAMPQTLPTPMRGEFYRTLTAILPPELNRVFPVNSGTEANEAALKFARAHTGRKKFVAAMRGFSGRTMGSLSVTWEPKYREPFLPLVEPVEFIPYNDVEALKRAVDEETAAVILEPVQGEGGVRPATPEFLRAAREITQEKGALLILDEIQTGMGRTGKRFAFEHFGIVPDILTLAKALGGGVPLGAAVMREEVARSMPKGGHGTTFGGNPLAMAAGVAAIRYLERTRLWERAAELGPWFMEKLRAIPSPKIREVRGMGLMVGLELKEKAAPYIARLEKEHRVLALQAGPTVIRFLPPLVIEKEDLERVVEAVRAVLA
What is the function of this protein?
Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine.
What are the official names of this protein?
[LysW]-aminoadipate semialdehyde transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_BRUSU
Sequence: MTMENKPAGQNGLTYAQAGVDIDAGNLMVEKIKPLVRSTRRPGADGEIGGFGGLFDLKAAGFKDPVLVAANDGVGTKLKIAIDADIHDTVGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLSPDQGVAIVSGIAEGCRQAGCALIGGETAEMPGMYRDGDYDLAGFAVGAAERDRLLPRGDIAEGDIILGLASSGVHSNGFSLVRRIVELSGLGWKSQAPFQPGATLGEALLTPTRIYVKPLLAAIRACDGIKALAHITGGGFPDNIPRVLPKGLAAEIDLPAIAVPPVFSWLAKTGNVEPNEMLRTFNCGIGMIAVVNPAKVDEVIAALAAEGEKVVTLGRMTRREKDGVIYKGQLAL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4C_MORIN
Sequence: MNYFPWLTIIIVLPIFAGFLILFLPHRGNKVIRWYTLCICIIELLLTTYAFGYHFQLDDPLIQLAEDYKWIDFLDFSWRLGIDGISIGPILLTGFITTLATLAARPVTRESRVFHFLMLAMYSGQIGPFSSQNLLLFFIMWELELIPVYLLLSMWGGKKRLYSATKFILYTAGSSAFLLVGILGICLSASNEPTLNFETSANQSYPVALEMLFYIGFFIAFAVKSPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLVRINMELLPHAHSIFSPWLMIVGTIQIIYAASTSPGQRNLKKRIAYSSVSHMGFIIIGLGSINDTGLNGAILQIISHGFIGAALFFLAGTSYDRIRLVYLDEMGGMAITIPKIFTTFSILSMASLALPGMSGFVAELILFFGILTSQKYLLMTKILITFVMAIGMILTPIYSLSMLRQMFYGYKLFTATNSYFVDSGPREFFVSISILLPVIAIGIYPDFVFSLSVDKVEALLSNYFYP
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y562_BIFLO
Sequence: MILVTTTPSVDGYTITNYQGIVFGEVVSGVNMFKDLGAGLRNMFGGRSQGYEEELMRARNEAIAEMQQRAEAMGAHAVVGVDIDYEVLGADNGMLMVTASGTAVQIARTA
What are the official names of this protein?
UPF0145 protein BL0562.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: SCPA_XYLFT
Sequence: MNSERAQIANPPTQTPVPQQQEIPLAMVHGQPVLQIPQDLYIPPDALEVILDAFEGPLDLLLYLIRRQNLNILDIPVAEITRQYVDYINVMQELRFELAAEYLVMAAILAEIKSRMLLPRPPDIENEEGEDPRAELVRRLQEYERFKQAAEDLDALPRMDRDNSAAHAFVPDQTTVRIPPPVNMKELLLALQDVLKRAELFSGHAIRREALSVRQRMGDILAHLEGGKFHPFTALFTAEEGKLGVLVTFLAILELAKEQLLDIVQEASLGPIYIKSLATHHTNGALQLSSDFDNSPSTHVPP
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: MENC_SALPK
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLRDGEREGWGEISPLPGFSQETWEEAQTALLTWVNDWLQGSEGLPEMPSVAFGASCALAELTGVLPEAADYRAAPLCTGDPDDLVLRLADMPGEKIAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKAQQFAKYVNPDYRARIAFLEEPCKTRDDSRAFARETGIAIAWDESLREADFTFEAEEGVRAVVIKPTLTGSLDKVREQVAAAHALGLTAVISSSIESSLGLTQLARIAAWLTPGTLPGLDTLHLMQAQQIRPWPGNALPCLKRDELERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: GLSA_AERHH
Sequence: MVLSSELLTSILDEVRPLLGQGKVADYIPALAQVPADRLGIAVCTVEGELFTAGDASEPFSIQSISKALSLTLALTLYQEEEIWARVGKEPSGQPFNSLVQLEFEQGIPRNPFINAGALVVSDLLETRLTAPRQRTLELVRRLSGNPAIMADQVVARSEYQHSARNAAIAYLMKAYGNFENEVDKVLQSYFNACAIRMSCVDLARAFIYLANRGVPLGATTPLLPARTTKQVNALLATCGLYDEAGDFAYRVGMPGKSGVGGGIIALIPGELCVCVWSPELNKAGNSLAGTAALELLAERLGRSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: NU6C_CICAR
Sequence: MALPETLHDFLLVFLGSGLILGSLGVVLLTNPIFSAFSLGLVLVCISLFYILSNSHFVAASQLLIYVGAINILIIFAVMFMNSSEYYQDFNLWTVGDGITLIVCTSIFVSLVTTIPDTSWYGIIWTTRPNQIIEQDLISTSQQIGIHLSTDFFLPFELISIILLVALIGTIVVARQ
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y2576_CLOBL
Sequence: MAIKLINIGFGNIVSANRLVAIVSPESAPIKRIIQEARDRGMLIDATYGRRTRAVIITDSDHVILSAVQPETVAHRLASKAEEEDINEGEE
What are the official names of this protein?
Putative regulatory protein CLI_2576.
What is the protein family that this protein belongs to?
Belongs to the RemA family.
Protein: SYK_THEP1
Sequence: MLKEFKEQRLNEIQELRSMGIEPYPYKFEKELTAREIREKYDYLQAGEVLESEKLSFAGRVMSIRHHGKTAFFHMKDDTGRIQAYVRADSVGKEKMDLFKRHVKIGDFIGVRGFPFKSKTGELTIYVQEYTLLSKALRPLPEKWHGIKDKEIIYRQRYLELIVSDEAIERFRKRFKAVQVIREFLNSRGFIEVETPILHYVTGGAEARPFVTHLNVFDIDMYLRIAPELYLKRLIIGGFEKIYEIGKNFRNEGISYKHSPEFTSIEIYQAYADYNDMMDLTEELIVEVVKRTCGTLKISYQGKEIDFTPPWKRVRMRDFLKEKLGVDILEDPDEVLLKKLEEYGVELEIKNRAHLIDKLRDLVEEELVNPTFIIDHPVVISPLAKRHREDPRLTERFELIIFGREIANAFSELNDPVDQYQRFLEQAKMREEGDEEAHMMDLDFVRALEYGMPPTGGLGIGLDRLFMFITDSPTIRDVIPFPIVKPQKFEEEEAEFEGGFEE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CE104_HUMAN
Sequence: MPHKIGFVVVSSSGHEDGFSARELMIHAPTVSGWRSPRFCQFPQEIVLQMVERCRIRKLQLLAHQYMISSKIEFYISESLPEYFAPYQAERFRRLGYVSLCDNEKTGCKARELKSVYVDAVGQFLKLIFHQNHVNKYNIYNQVALVAINIIGDPADFSDESNTASREKLIDHYLGHNSEDPALEGTYARKSDYISPLDDLAFDMYQDPEVAQIIRKLDERKREAVQKERYDYAKKLKQAIADLQKVGERLGRYEVEKRCAVEKEDYDLAKEKKQQMEQYRAEVYEQLELHSLLDAELMRRPFDLPLQPLARSGSPCHQKPMPSLPQLEERGTENQFAEPFLQEKPSSYSLTISPQHSAVDPLLPATDPHPKINAESLPYDERPLPAIRKHYGEAVVEPEMSNADISDARRGGMLGEPEPLTEKALREASSAIDVLGETLVAEAYCKTWSYREDALLALSKKLMEMPVGTPKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYIPKHKLSKLETAHCVERTIPVLLTRTGDSSARLRVTAANFIQEMALFKEVKSLQIIPSYLVQPLKANSSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALEHRVYEVRETAVRIILDMYRQHQASILEYLPPDDSNTRRNILYKTIFEGFAKIDGRATDAEMRARRKAATEEAEKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDNLCIFCGERSESFTEEGLDLHYWKHCLMLTRCDHCKQVVEISSLTEHLLTECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGLSKSSSRTYAKR
What is the function of this protein?
Required for ciliogenesis and for structural integrity at the ciliary tip.
What are the official names of this protein?
Centrosomal protein of 104 kDa, Cep104.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase non-ciliated cells, localizes to the distal ends of both the mother and daughter centrioles. In ciliated cells, present at the distal end of the daughter centriole, but not on the mother centriole, and at the tip of primary cilium. Localization at the ciliary tip is also observed in motile cilia. Throughout S phase, associated with both mother and daughter centrioles in each centrosome. During metaphase and telophase, present at both spindle poles.
Protein: DCP2_PONAB
Sequence: METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLSQCGIRDFAKAVFSHCPFLLPEGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSTGSTPAKPTVEKLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKPYNNHSEMSDLLKGKKCEKKLHPRKLQDNFETDAVYDLPSSNEDQLLEHAEGQPVACNGHCKFPFSSRAFLSFKFDHNAIMKILDL
What is the function of this protein?
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs.  Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP.  Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay.  Plays a role in replication-dependent histone mRNA degradation.  Has higher activity towards mRNAs that lack a poly(A) tail.  Has no activity towards a cap structure lacking an RNA moiety.  The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping.  Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
What are the official names of this protein?
m7GpppN-mRNA hydrolase, mRNA-decapping enzyme 2.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. DCP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear.
Protein: ILVD_SHESR
Sequence: MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVAGAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIKLDLVDAMVAAADSSVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHSDRRELFLEAGRRVMALTKRYYEQDDVSALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDDIDRMSRQVPHLCKVAPSTAKYHMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNLKSVLAKYDVMQTQDDKVKQFFMAGPAGIPTTKAFSQDCRWPSLDDDRREGCIRSREFAFSQEGGLAVLSGNLADNGCIVKTAGVDESNLTFTGSARVYESQDDAVAGILGGEVVAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIPKRSIKLAVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYAMLATSADKGAVRDRSKLED
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: TRMN6_PASMU
Sequence: MSAKQNGFTFKQFHIDHHRCAMKVGTDGILLGAWADVSQSERILDLGTGTGLIALMLAQRSTKESEIHAVELDQAAYLQAQANVHASPWAQRVHVYQQDAAEFCRNAVNKFDLIVANPPYFPQGVDCATPQRDLARYTATHRHVDWLNWASHCLSEQGKISMVLPFEAGETLLKQTALYCIARCEVITKKGKAPQRLLLTFSLQAQPLQPSQLIIYDESNRYHPDFIGLTKDFYLAF
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLPHP_HUMAN
Sequence: MWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHAVEVGSTNVRIGSTIFGERDYSKKPTPDKCAADVKAPLEVAQEH
What is the function of this protein?
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
What are the official names of this protein?
Pyridoxal phosphate homeostasis protein, PLP homeostasis protein, Proline synthase co-transcribed bacterial homolog protein, Pyridoxal phosphate-binding protein.
What is the protein family that this protein belongs to?
Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
Protein: CXG1_RAT
Sequence: MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKTSVWI
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
What are the official names of this protein?
Gap junction gamma-1 protein, Connexin-45, Cx45, Gap junction alpha-7 protein.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Gamma-type subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: HSCA_EDWI9
Sequence: MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLADEQGHHLLPSVVRYQAGGHIVGAEAREQAADDPLNTVSSIKRMMGRSLADVQARYPHLPYQMHASESGMPQLATAAGSVNPIQVSADILAALSARAQAALGGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSAQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADWLREQAGLRDRSDAGLARRFLDAAVAAKIALSTQQETTVCVGDWQGEVSRDQLDALIAPLVKRTLLACHRTLKDAGVTRDEVLEVVMVGGSTRVPLVRTQVGDFFGRQPLTTIDPDRVVAIGAAIQADILVGNKPDADMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQEFTTFKDGQTAMMIHVLQGERELVQDNRSLARFTLRGIPPLSAGGAHIRVTFQVDADGLLSVTAMEKSTGVQAAIQVKPSYGLSEDEIVGMLKDSMANAEGDLSARMLAEQKVEAARVLESLHGALQQDSALLGEQELAAIRQAQTALQAAADGDETSAIEAAIKVLDAQTQEFAARRMDSSIRRALAGHSVDEV
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU.
What are the official names of this protein?
Chaperone protein HscA, Hsc66.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RMF_AERVB
Sequence: MMKRQKRDRLERARARGYQAGVVGKQKEACPYQCLDARGHWLGGWRDAMEGRGSGLFMK
What is the function of this protein?
During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes).
What are the official names of this protein?
Ribosome modulation factor, RMF.
What is the protein family that this protein belongs to?
Belongs to the ribosome modulation factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_AZOVD
Sequence: MHKLTPRQVEILAFIKRCLEENGYPPTRAEIARELGFKSPNAAEEHLKAMARKGAIEMTPGASRGIRIPGSEVESEPTSLPIVGRVAAGAPILAQQHIEETCQIDPGFFHPRADYLLRVRGMSMKDVGIYDGDLLAVHTCREAHNGQIVVARLNDEVTVKRFRRDGDKVWLIAENPEFSPLEIDLTEQDLTIEGLSVGVIRR
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: NUOA_AERHH
Sequence: MFADIAVQHWAFAVYVVGAICICLTMIGLAALLGGRAYGRAKNKPFESGVDSVGNARLRFSAKFYLVAMFFVIFDVEALYLFAWSVSVRESGWVGFIEATIFISLLLVGLIYLWRIGALDWAPKKRVLTDKKPD
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL27A_TENMO
Sequence: MSTHKKKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGMHHHRINFDKYHPGYFGKLGMRNYHLRRNSKWAPAINLDKLWTLVSEQTRSKYQNHPEGKAPVIDIVKAGYYKLLGKGACLTNLSLLKPSFSLNRLEDKIKAVGGACVLSA
What are the official names of this protein?
60S ribosomal protein L27a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: SPCS2_DROME
Sequence: MGKKDEKSQQGEELVKVNKWDGSAVKHALDDAVKTCLLGDRPQLKEQFGLVNTRLALCALAVSVAIMAHAWDFTHPFPESRPVLLFSVLAYFALLGILTLHSSFREKGTFAVALQKDKERERLWEASSDMRKYDDKYLLTLSVRDTKNGKRREQSSNKSCAAFIDQNGIVLDNLVANEVNRLFNALAADKKNASSLSSN
What is the function of this protein?
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
What are the official names of this protein?
Signal peptidase complex subunit 2, Microsomal signal peptidase 25 kDa subunit, SPase 25 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the SPCS2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL3_POLSJ
Sequence: MSLSNSLGLLGRKVGMMRLFTDDGDTVPVTVVDVSNNRVTQVKTEANDGYDALQVAFGARKASRVTKPAAGHLAKAGVEAGEILKEFRVTADVAGKYAAGTVVPAADVFAVGQLVDVQGTSIGKGYAGTIKRHNMSSQRASHGNSRSHNVPGSIGMAQDPGRVFPGKRMTGHLGDVTVTTQNLNIVRIDEARQLLMIRGAVPGSKGGFVTVRAAIKAKPTTAAKGAN
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: KDGGP_BACTN
Sequence: MKEIKLILTDIDGVWTDGGMFYDQTGNEWKKFNTSDSAGIFWAHNKGIPVGILTGEKTEIVRRRAEKLKVDYLFQGVVDKLSAAEELCNELGINLEQVAYIGDDLNDAKLLKRVGIAGVPASAPFYIRRLSTIFLEKRGGEGVFREFVEKVLGINLEDFIAVIQ
What is the function of this protein?
Involved in the biosynthesis of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid used in cell-wall polysaccharides (PubMed:18804026).  Catalyzes the hydrolysis of 2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid (KDN-9-P) to yield 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (PubMed:18804026, PubMed:18986982, PubMed:23848398).  Also able to hydrolyze N-acetylneuraminate-9-phosphate (Neu5NAc-9-P), 2-keto-3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P), phosphoenolpyruvate (PEP), gluconate 6-phosphate, tyrosine phosphate ester and glucose-6-P as substrate (PubMed:18804026, PubMed:18986982, PubMed:23848398).
What are the official names of this protein?
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid phosphatase, KDN-9-P phosphatase, 2-keto-3-deoxy-D-glycero-D-galacto-nonic acid-9-phosphate phosphatase, KDN9PP, 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the KdsC family.