PharMolix/UniProtQA huggingface dataset:
Protein: TNFB_PANTR
Sequence: MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL
What is the function of this protein?
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity).  In its heterotrimeric form with LTB binds to TNFRSF3/LTBR.  Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo (By similarity).
What are the official names of this protein?
Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane- associated.
Protein: IDH3A_CAEEL
Sequence: MLGKCIKKASSTVGQSIRYSSGDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIPSRCIELMHANKVGLKGPLETPIGKGHRSLNLAVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTAVHKANIMRQSDGLFLSICREQAALYPDIKFKEAYLDTVCLNMVQDPSQYDVLVMPNLYGDILSDLCAGLVGGLGVTPSGNIGKGAAVFESVHGTAPDIAGQDKANPTALLLSAVMMLRYMNLPQHAARIEKAVFDAIADGRAKTGDLGGTGTCSSFTADVCARVKDLE
What are the official names of this protein?
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitric dehydrogenase subunit alpha, NAD(+)-specific ICDH subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DCD_XANCP
Sequence: MSIKSDRWIKRMAEQHAMIEPFEPGQIKHDAAGQRIVSFGTSSYGYDVRCSREFKIFTNINSTIVDPKHFDPGSFVDIESDVCIIPPNSFALARTVEYFRIPRDTLVVCLGKSTYARCGIIVNVTPLEPEWEGRVTLEFSNTTPLPARIYANEGVAQMLFFQSDEVCETSYKDRGGKYQGQTGVTLPRT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: THII_LISW6
Sequence: MEFDRILIRYGELSTKGKNRKQFVTRLAHNVKRAMKDLPEVRIHGERDRMYIILNGEDHKLAEERLKPIFGIQSFSPAVRVNLELDEVKNAALALVQDVHEQNGTFKVAARRSHREFPLDSNEINQEIGAYVLQNIEDLSVNVKNPDVKLTIDVRKEGVFLSCRTIIGAAGLPVGSSGRAMLMLSGGIDSPVAGYLAQKRGVEIEAVHFHSPPYTSEQAKQKAVDLAAKLAKYGGEVKMHIVPFTEIQEMIKQQIPESVIMTVTRRMMLKITDELRRKRNGLAIVNGESLGQVASQTLESMLAINAVTTTPIIRPVVSMDKNEIIQIAQKIDTYNLSVQPFEDCCTIFTPPSPKTKPKLDKIERYESFTDFDSLITKALDNIETITVNITENTQVKDEFADLF
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODP3_SOLTU
Sequence: SSADSLPXHGAGXMP
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
55 kDa dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, 55 kDa dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, Pyruvate dehydrogenase complex component E2 2, PDC-E2 2, PDCE2 2.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: B2S21_SYLSP
Sequence: MFTLKKPLLFLFFLGTISLSFCEEERGADEDDGGEMTEEEKRGVLDTLKNVAIGVAKGAGTGVLKALLCQLDKSC
What is the function of this protein?
Antimicrobial peptide.  Active against some Gram-negative and a variety of Gram-positive bacterial strains.  Active against fungus C. glabrata 090902 but not against C. albicans ATCC 10231.  Shows hemolytic activity against human erythrocytes.
What are the official names of this protein?
Brevinin-2SN2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TTCA_ECO55
Sequence: MSQNQEISKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHVLPEYLEKLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIQRFADAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVNGGDLAFDREEIPLQPVGWQPEEDENQLDELRLNVVEVK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_COPPD
Sequence: MSVLIIDGGIPLKGKVTAQGCKNSALAILAAAALCEDRVYLTNVPDIGDVKTMMSILRSLGYKVTWGSGLTIKPGVIKNYDLTHTGAGSIRGSLLFLGALLGRLGKVVLPMPGGCNIGTRPIDLHLKGLSLMGASLDIQGGNIVGEAPSGLKGAYVYLDFPSVGATENIMIAGALASGETTIENAAQDQQVVELGKFLMACGVKIHGLGTKVIRIKGKKEIGGVTFRISGDSIEAGTYAIAAAATRGSITVDGVDVTFLRPLLFKLQEAGIEVVVTNGHEVTVLPSPRPKGITIKTMPFPGFPTDLQPLMMSLLATAEGRSVITETVYDGRMGHVSELWKMGANIEVEGNTAIITGVEKLTGAPVVANNLRAGAALVVAGLSAEGRSVVYGMEHVMRGYSNIHQKLRALDAKVELVSDEEAVNIA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG112_VACCC
Sequence: MEMDKRIKSLAMTAFFGELNTLDIMALIMSIFKRHPNNTIFSVDKDGQFMIDFEYDNYKASQYLDLTLTPISGDECKTHASSIAEQLACADIIKEDISEYIKTTPRLKRFIKKYRNRSDTRISRDTEKLKIALAKGIDYEYIKDAC
What is the function of this protein?
Contributes to the formation of crescents and immature virions (IV).  Interacts with phosphatidylinositol-3-phosphate (PI3P) and phosphatidylinositol-4-phosphate (PI4P) lipids in order to form virion membranes.  Mechanistically, mediates proper formation of OPG125-hexamers, and hence the honey comb lattice and spherical immature virus.
What are the official names of this protein?
Late protein OPG112.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG112 family.
Protein: MAGA3_HUMAN
Sequence: MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE
What is the function of this protein?
Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy (PubMed:20864041, PubMed:31267705).  May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28.  Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041).  May play a role in embryonal development and tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041).  In vitro promotes cell viability in melanoma cell lines (PubMed:17942928).  Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes (PubMed:8113684).
What are the official names of this protein?
Melanoma-associated antigen 3, Antigen MZ2-D, Cancer/testis antigen 1.3, CT1.3, MAGE-3 antigen.
Protein: VP92_FDVS
Sequence: MDTSHKVYNFECPFELAKVEMKAISNTMHKVDDFVSTIDVNFSDSELDDKVDDLEIKIEKVSGPLLNRYLGSVGKVVFLIFSFLFFGSIKLVLKCFYHLFKCVFCNPLTRCFCSIIFTIIFYTLLFVSCYLLWHYFGDVIIQTIKDINNNRSVNFTNETENFNSKVETTTMKIIQLIFSKSDNNGVEHIIKSANVTSGQTANFTLLNG
What are the official names of this protein?
Uncharacterized protein VP9-2.
Protein: ZN740_MOUSE
Sequence: MMLSQIASKQAENGERAGSPDVLRCSSQMDCKPRFDLSSKGHRKDSDKSRNRKEDDSLAEASHSKKTVKKVVVVEQNGSFQVKIPKNFICEHCFGAFRSSYHLKRHVLIHTGEKPFECDVCDMRFIQKYHLERHKRVHSGEKPYQCERCHQCFSRTDRLLRHKRMCQGCQSKTSEGQFSL
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 740.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RR15_BARVE
Sequence: MIKNAFISFQEQKEESKGSVEFQVFSFTNKIRRLTSHLELHRKDYLSQRGLRKILGKRQRLLAYLSKKNRVRYKELINQLNIRELKTR
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: 4HYPE_BRUA2
Sequence: MARHSFFCVDGHTCGNPVRLVAGGGPNLNGSTMMEKRAHFLAEYDWIRTGLMFEPRGHDMMSGSILYPPTRPDCDVAVLFIETSGCLPMCGHGTIGTVTMAIEQGLVTPKTPGKLNLDTPAGLVAIEYEQDGQYVERVRLTNVPAFLYAEGLEVECPDLGPIKVDVAYGGNFYAIVEPQENYTDMDDYSALQLIAWSPVLRQRLNEKYKFQHPELPDINRLSHILWTGKPKHPQAHARNAVFYGDKAIDRSPCGTGTSARMAQLAAKGKLKPCDEFIHESIIGSLFHGRVERAAEVAGRPAIVPSIAGWARMTGYNTIFIDDRDPFAHGFSMA
What is the function of this protein?
Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4-hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases.  Strong B-cell mitogen.  Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways (By similarity).  Directly involved in the immune regulation of host.  Elicits B-lymphocyte polyclonal activation, resulting in early and transient nonresponsive immune condition of the host.
What are the official names of this protein?
4-hydroxyproline epimerase, Hydroxyproline-2-epimerase, HyPRE.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: OXLA_CRODC
Sequence: ADDRNPLEQCFRETDYEEFLEIARNNLKATSNPKHVVIVGAGMAGLSAAYVLSGGGHQVTV
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:16307769).  Shows activity on L-Leu (PubMed:16307769).  Exhibits diverse biological activities, such as apoptosis, antibacterial activities against both Gram-negative and Gram-positive bacteria and antiparasitic activities, as well as induction of platelet aggregation (PubMed:16307769).  Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation (By similarity).  These different effects are probably due to different experimental conditions (By similarity).  This protein may also induce hemorrhage, hemolysis, and edema (By similarity).
What are the official names of this protein?
L-amino-acid oxidase, Casca LAO, LAAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TSAC_PSEPG
Sequence: MVSSFRVQQAAREIRAGAVIAYPTEAVWGLGCDPWNEDAVYRLLALKSRPVDKGLILIADNIRQFDFLFEDFPEDWIERMGSTWPGPNTWLVPHQDLLPEWVTGKHDTVALRVTDHPQVRELCALVGPLISTSCNPGGRPAAKTRLRVEQYFHGQLDLVLGGALGGRKNPSVIRNLATGEVVRPG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAGP_LEGP2
Sequence: MKRLISCLTIICALNASAAAETTSNPCSRWISFLKPVCQRIHQTWAEGHDDMYFSGYAWHNRYVYSNEKIKSYNETAWGGGLGKSLFDEKGNWHGLYAIAFLDSHRHLEPAVGYAYLKTASVNKDLKAGLGYSVLVTSRVDYDNVPIPGALPWAALFYKRITIAATYIPGSSREGHENGNVLYMLGKISL
What is the function of this protein?
Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors.
What are the official names of this protein?
Lipid A acyltransferase PagP, Lipid A acylation protein.
What is the protein family that this protein belongs to?
Belongs to the lipid A palmitoyltransferase family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: CBF5_KLULA
Sequence: MSDEFVIKPESVSPSSNTSEWPLLLKDYDKLLVRSGHYTPIPAGASPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCEKTGHSGTLDPKVTGCLIVCVDRATRLVKSQQGAGKEYVCIVRLHDALKDEKELGRGLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGALSENDNLVTLHDVMDAQWVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEEGIELYDEVVLITTKGEAIAVAIAQMSTVDLATCDHGVVAKVKRCIMERDLYPRRWGLGPIAQKKKQMKADGKLDKYGRANENTPETWKKTYVSLENAEPTTAPASKSEEKPLIKEVEKKEVEQKEESKEESKTPEEKKDKKEKKEKKDKKEKKEKKEKKEKKRKADDDESSEKKKKKSKK
What is the function of this protein?
Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing.  The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs.  Catalyzes pseudouridylation at position 93 in U2 snRNA.  Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit CBF5, Centromere-binding factor 5, H/ACA snoRNP protein CBF5, Small nucleolar RNP protein CBF5.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: YCIU_ECO45
Sequence: MDMDLNNRLTEDETLEQAYDIFLELAADNLDPADVLLFNLQFEERGGAELFDPAEDWLEHVDFDLNPDFFAEVVIGLADSEDGEINDVFARILLCREKDHKLCHIIWRE
What are the official names of this protein?
UPF0263 protein YciU.
What is the protein family that this protein belongs to?
Belongs to the UPF0263 family.
Protein: GPRL1_HUMAN
Sequence: MALKNKFSCLWILGLCLVATTSSKIPSITDPHFIDNCIEAHNEWRGKVNPPAADMKYMIWDKGLAKMAKAWANQCKFEHNDCLDKSYKCYAAFEYVGENIWLGGIKSFTPRHAITAWYNETQFYDFDSLSCSRVCGHYTQLVWANSFYVGCAVAMCPNLGGASTAIFVCNYGPAGNFANMPPYVRGESCSLCSKEEKCVKNLCRTPQLIIPNQNPFLKPTGRAPQQTAFNPFSLGFLLLRIF
What is the function of this protein?
Required for optimal fertilization at the stage of sperm-oocyte fusion, plays a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction and the fertilization process.  Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation.  Also component of the CD9-positive microvesicules found in the cauda region.
What are the official names of this protein?
GLIPR1-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Note=Located in the connecting piece of elongated spermatids and sperm. Also located in the apical region of the sperm head after sperm capacitation. Located on sperm equatorial segment and neck. Associated with epididymosomes from the caput and cauda epididymis.
Protein: RL30_ACET2
Sequence: MAKLKITLVRSISKLNESQTATVRALGLRKRGSCVEQQDTPQIRGMIKKVEHVLSVEEI
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: P2RY1_HUMAN
Sequence: MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
What is the function of this protein?
Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790).  In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).
What are the official names of this protein?
P2Y purinoceptor 1, P2Y1, ADP receptor, Purinergic receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: XYNA_ASPTN
Sequence: MVSFLRLAVACFAAVGALAAPVESLEERSDELFNSTLHEFAERSTPSSTGWSNGYYYSFWTDGGGSVTYTNGAAGQYSVQWSNVGNFVGGKGWNPGSARTINYGGSFNPSGNGYLAVYGWTTNPLVEYYVVESYGTYNPGSGGTYKGTVNSDGGTYNIYTATRYNAPSIIGTATFTQYWSVRTSKRTGGTVTMANHFNAWASHGMNLGTHNYQIVATEGYQSSGSSSITVY
What is the function of this protein?
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
What are the official names of this protein?
Probable endo-1,4-beta-xylanase A, Xylanase A, 1,4-beta-D-xylan xylanohydrolase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 11 (cellulase G) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSD10_MOUSE
Sequence: MEGCVSNIMICNLAYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLVKGAHVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLACDEERVEEAKFLVTQGASIYIENKEEKTPLQVAKGGLGLILKRLAESEEASM
What is the function of this protein?
Acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53.  Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1.  Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4.  Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome.  Involved in p53-independent apoptosis.  Involved in regulation of NF-kappa-B by retaining it in the cytoplasm.  Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export (By similarity).
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit p28, Gankyrin.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FETP_ECOLU
Sequence: MSRTIFCTFLQREAEGQDFQLYPGELGKRIYNEISKEAWAQWQHKQTMLINEKKLNMMNAEHRKLLEQEMVNFLFEGKEVHIEGYTPEDKK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: ZN628_HUMAN
Sequence: MSGVMVGSHADMAPASTAEGAGEKPGPAAPAPAAQYECGECGKSFRWSSRLLHHQRTHTGERPYKCPDCPKAFKGSSALLYHQRGHTGERPYQCPDCPKAFKRSSLLQIHRSVHTGLRAFICGQCGLAFKWSSHYQYHLRQHTGERPYPCPDCPKAFKNSSSLRRHRHVHTGERPYTCGVCGKSFTQSTNLRQHQRVHTGERPFRCPLCPKTFTHSSNLLLHQRTHGAAPAPGTASAAPPPQSREPGKVFVCDAYLQRHLQPHSPPAPPAPPPPPPPVVPELFLAAAETTVELVYRCDGCEQGFSSEELLLEHQPCPGPDAAPQPQEAPAEAPKADQPPSPLPQPPPPAAAPAPGFACLPCGKSFRTVAGLSRHQHSHGAAGGQAFRCGSCDGSFPQLASLLAHQQCHVEEAAAGRPPPQAEAAEVTCPQEPLAPAAPVPPPPPSAPASAERPYKCAECGKSFKGSSGLRYHLRDHTGERPYQCGECGKAFKRSSLLAIHQRVHTGLRAFTCGQCGLTFKWSSHYQYHLRLHSGERPYACGECGKAFRNTSCLRRHRHVHTGERPHACGVCGKSFAQTSNLRQHQRVHTGERPFRCPLCPKTFTHSSNLLLHQRTHSAERPFTCPICGRGFVMAAYLQRHLRTHAPANTPPSTTAPAAGPQPPAPLAAARAPPATQDVHVLPHLQATLSLEVAGGTAQAPSLGPAAPNSQTFLLVQTAQGLQLIPSSVQPPTPPPPPAPPKLILLPSSSAGAGGGRARQGPRAVGKAGQGAGVVWLPGPGGLGVQGAASAGASGTGQSLIVLQNVGGGEAGPQEMSGVQLQPLRPAPEVTTVQLQPAQEVTTVQLQPAQEVTTVQLQPAQEVTTVQLQPVAGQLSNSSGGAVATEAPNLLVVQSGAAEELLTGPGPGEAGDGEASTGVVQDVLFETLQTDEGLQSVLVLSGADGEQTRLCVQEVETLPPGLTEPPATGPPGQKLLIIRSAPATELLDSSNTGGGTATLQLLAPPPSGPASGPAGLPGAPASQMVQVVPAGAGPGVMTPQGLPSIQIVQTLPAVQLVHTF
What is the function of this protein?
Transcriptional activator.  Binds DNA on GT-box consensus sequence 5'-TTGGTT-3'.  Plays a role in spermiogenesis.
What are the official names of this protein?
Zinc finger protein 628.
What are the subcellular locations of this protein?
Nucleus.
Protein: ERLN2_RAT
Sequence: MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPHAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTALKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGGLGKQSEGLSDKLGFGLEDEPLETATKDN
What is the function of this protein?
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1.  Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex.  Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.  May promote ER retention of the SCAP-SREBF complex (By similarity).
What are the official names of this protein?
Erlin-2, Endoplasmic reticulum lipid raft-associated protein 2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2, SPFH domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.