PharMolix/UniProtQA huggingface dataset:
Protein: YBOX1_XENLA
Sequence: MSSEVETQQQQPDALEGKAGQEPAATVGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPEGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNNESGEKAEENESAPEGDDSNQQRPYHRRRFPPYYSRRPYGRRPQYSNAPVQGEEAEGADSQGTDEQGRPARQNMYRGFRPRFRRGPPRQRQPREEGNEEDKENQGDETQSQPPPQRRYRRNFNYRRRRPENPKSQDGKETKAAETSAENTSTPEAEQGGAE
What is the function of this protein?
DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation (By similarity).  Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity).  Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and preventing mRNA decay (By similarity).  Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation (By similarity).  Also promotes maternal-to-zygotic transition in oocytes and embryos by promoting translation repression; molecular mechanisms governing translation repression are unknown (By similarity).  Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (By similarity).  Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity).  Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (By similarity).  Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity).  Also able to bind DNA and regulate transcription (PubMed:2247479).  Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3') (PubMed:2247479).  Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (By similarity).  Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (By similarity).  The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity).
What are the official names of this protein?
Y-box-binding protein 1, YB-1, Y-box transcription factor.
What is the protein family that this protein belongs to?
Belongs to the YBX1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Secreted, extracellular exosome.
Protein: LACA2_STRPM
Sequence: MAIIIGADKAGQELKEVIKDYLKEGKYEVVDVSENEVRDFVDTTLAVAKEVNASEDNLGIVIDAYGVGSFMVATKIKGMVAAEVSDERSAYMTRGHNNARIITLGSEISAPGIAKNIIKGFVEGKYDGGRHQVRVDMLNKMC
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacA 2.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: CCD43_DANRE
Sequence: MAAPEQIAGEFENWLNERLDSLEVDREVYGAYILGVLQEEESDEEQKDALQGILSAFLEEETLEEVCQEILKQWTECCSRSGAKSNQADAEVQAIASLIEKQAQIVVKQKEVSEDAKKRKEAVLAQYANVTDDEDEAEEEEQVPVGIPSDKSLFKNTNVEDVLNRRKLQRDQAKEDAQKKKEQDKMQREKDKLSKQERKDKEKKRTQKGERKR
What are the official names of this protein?
Coiled-coil domain-containing protein 43.
What is the protein family that this protein belongs to?
Belongs to the CCDC43 family.
Protein: NADE_ECO81
Sequence: MTLQQQIIKALGAKPQINAEEEIRRSVDFLKSYLQTYPFIKSLVLGISGGQDSTLAGKLCQMAINELRQETGNESLQFIAVRLPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAVLASEQALREAGIELSDFVRGNEKARERMKAQYSIAGMTSGVVVGTDHAAEAITGFFTKYGDGGTDINPLYRLNKRQGKQLLAALGCPEHLYKKAPTADLEDDRPSLPDEVALGVTYDNIDDYLEGKNVPEQVARTIENWYLKTEHKRRPPITVFDDFWKK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: O26C_CONVC
Sequence: MQKLIILLLVAAVLMSTQALFQEKRPMKKINFLSKGKTDAEKQRKRSCSDDWQYCEYPHDCCSWSCDVVCS
What is the function of this protein?
Inhibits voltage-gated ion channels.
What are the official names of this protein?
Conotoxin Vc6.12.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LSPA_PSEA6
Sequence: MLNLFRQSGLRFLWLAVVVFVIDQVTKHWIVANLEPYQAIQYTSFFNLTHVYNYGAAFSFLSDAGGWQRWLFTGIAIAVCGLVTWWLKETTRQQVMLPVAFCLIIGGALGNVFDRLLHGFVIDFLVLYYQDWYWPAFNVADSAICLGAFLLVIDMFKNKDNVNE
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FAF4_ARATH
Sequence: MATVVYQSYFESQHFEPRALRLRLSSHTNPQLSTPLKSHFQNSSIAPQDNPITINAASLPSSSPNPSSNSDTNSGSWSFLESLSNSSSNDKEKKTLPLFQSPSSRRTLSDESLALCTESLGSETGSDIIHEDMFSISSELQTMETRTTSTTSNPSRQDRKRNTMASLPPPLTSMIGFDCIEVKSHRENGRLVMMATRPPPRNRCLQDRSNGCVRLAILIDSDDHIETETKEEKEEEEEETIETVRDNEEEIPEYKEEEEEKEEEIKVKGVEKVQRSRRCIEGDRENRGFLNWESLCVATS
What is the function of this protein?
Regulates the size of the shoot meristem by modulating the CLV3-WUS feedback loop.  Can repress WUS but is under negative control by CLV3.
What are the official names of this protein?
Protein FANTASTIC FOUR 4.
What is the protein family that this protein belongs to?
Belongs to the fantastic four family.
Protein: PORB_METTM
Sequence: MKIPEEEFLAPGHRGCAGCGATVGVRLALKVLGKNTVAVSSTGCLEVITTPYPETAWEIPWIHVAFENAAAVASGVERALRARGRGEVNVVAFAGDGGTADIGLQSLSGAMERGHNIIYICYDNEAYMNTGIQRSASTPYGASTTTSPHGKESFGEDRPKKNMPLIMAAHGVPYVATASISYPEDFMEKVRKARDIEGPAYIHLHQPCTTGWGFDPSKTVELGRLAVETGSWILYEIEDGDFRVTYRPVQRKPVEEYLNAQKRFRHLTEEQKAKIQEYVDSVCQELRI
What are the official names of this protein?
Pyruvate synthase subunit PorB, Pyruvate oxidoreductase beta chain, POR, Pyruvic-ferredoxin oxidoreductase subunit beta.
Protein: RS7_COREF
Sequence: MRKSAAPKRPVVKDPVYDSELVTQLVNKILLDGKKSTAERIVYGALEICREKTGLEPVGTLEKALGNVRPDLEVRSRRVGGATYQVPVEVRPARATTLALRWLVTFTRQRRENTMVERLANEIMDAANGLGASVKRREDTHKMAEANRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RL19_RHOP2
Sequence: MNLIQTLEKEQFDKLSAGKTIPEFGPGDTVIVNVKVVEGERSRVQAYEGVCIGRSGGGINESFTVRKISYGEGVERVFPLLSPMIDSIKVVRRGKVRRAKLYYLRNLRGKSARIVEKKQDRPAKVAAGAAE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RPOY_STAAW
Sequence: MAVFKVFYQHNRDEVIVRENTQSLYVEAQTEEQVRRYLKDRNFNIEFITKLEGAHLDYEKENSEHFNVEIAK
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: BCAM_BOVIN
Sequence: MEPPDARAGARRAPRLLVLALLLAAPPGSKAEVRLSVPPLVEVMRGESVTLDCSPLGTHDYFMLEWFLVDRSGARHRLASAELRGSELRDKELNSRGRSPPYQLDSQGRLVLPEAQVGDERDYVCVVKAGAAGTAEATARLKVFAKPEAPEVSPNKGILSVMDDFAQEIATCSSRNGNPAPQIMWYRNGQPLAVPLEVNSEGYMTTRTVREASGLLSLTSTLYLRLHKPDREASFHCSVHYYLPAGQHGRLDGPSFSLTLHYPTEHVLFWLGSQSTAEGWVREGDSVQLLCQGDGSPTPEYTFFWLQDKQEDVLKTSLEGNLTLERVQRNQSGTYGCRVEDFDVPEDAELSKTLELRVAYLDSLELSAGEELSLPLHNSTTVTCSARGLPTPTLYWTKDSAPMGEDPTLSLHSVTFDSAGTYTCEAYMPRIPLLSRTRSFRLLVQGTPELKAKETQPKAEGSWTEGDEVTLICYARGYPKPKLTWSQLGGSPTEPAPGGQGWVSSSLTLKVTSALSQDGVSCEASNPLGNTHHVFHFGTVAPQTSQAGVAVMAVAISVALLLLVVAVFYCMRRKGRPGCCQWGEKGSPPPGEPKLSHSGSQRPEQTGLLMGSASGGAKHGSGGFGDEC
What is the function of this protein?
Laminin alpha-5 receptor.  May mediate intracellular signaling (By similarity).
What are the official names of this protein?
Basal cell adhesion molecule, B-CAM cell surface glycoprotein, Lutheran antigen.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: HIS8_BAUCH
Sequence: MSILNLARTNVLTLEPYQSARRIGGGSQGNIWLNANEYPQPTFYMLRSSNLNRYPDCQPQELLNSYAAYAGVQPNQVLACRGADEGIELLIRTFCEPSKDKILFCPPTYGMYRVSAETFGVAYCAIQALDNWQLDLDTIYAQLDCVKLIYICHPNNPTGNIINPSDIRQLLDITHGRTILVVDEAYIDFYPTASISSWINHYPHLVILRTLSKAFALAGLRCGFILANPDIIKLLLKVIAPYPISRPVVDIAKQALSTKGIHQTKRRVANIDINRNWLIQQLAECSCVSVVFPSVTNYLLVRFHPNYHVFQSLWKKGTILRDQNQQIGLANCLRITIGTSLECQNLLTALQALTLVSHKE
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: EUTC_ECO45
Sequence: MDQKQIEEIVRSVMASMGQAAPAPSEAKCATTNCAAPVTSESCALDLGSAEAKAWIGVENPHRADVLTELRRSTVARVCTGRAGPRPRTQALLRFLADHSRSKDTVLKEVPEEWVKAQGLLEVRSEISDKNLYLTRPDMGRRLCAEAVEALKAQCVANPDVQVVISDGLSTDAITVNYEEILPPLMAGLKQAGLKVGTPFFVRYGRVKIEDQIGEILGAKVVILLVGERPGLGQSESLSCYAVYSPRMATTVEADRTCISNIHQGGTPPVEAAAVIVDLAKRMLEQKASGINMTR
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: PGK_RUEPO
Sequence: MGWKTLDDMDLTGKRVLVRVDINVPIVDGVVTDSTRIRRLMPTIRDILAAGGRPILLAHFGRPGGERRKNLSLGQLVPTLERAFETKVLFADDCVGPAAEEAAEALQPGQVLLLENTRFHASETKNDPDLAAGMARLGDIYCNDAFSAAHRAHSSTEAIARLLPSCAGRLMQAELEALEKALGKPERPVTAVVGGAKVSTKLELLGNLIEKVDYLVIGGGMANTFLVAKGLPVGKSLAERIMKDTAAEILAKAEAAGCTIVLPSDVVVAEKFESHAPHQILPNDRCPDEGMILDAGPDSLAAIKAIFEKSRTLIWNGPLGAFELEPFDAATNAAALKAAALTRAGKLISVAGGGDTVAALNASGAAGDFTYISTAGGAFLEWMEGKTLPGVAALIQAG
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALDH5_YEAS7
Sequence: MLSRTRAAAPNSRIFTRSLLRLYSQAPLRVPITLPNGFTYEQPTGLFINGEFVASKQKKTFDVINPSNEEKITTVYKAMEDDVDEAVAAAKKAFETKWSIVEPEVRAKALFNLADLVEKHQETLAAIESMDNGKSLFCARGDVALVSKYLRSCGGWADKIYGNVIDTGKNHFTYSIKEPLGVCGQIIPWNFPLLMWSWKIGPALATGNTVVLKPAETTPLSALFASQLCQEAGIPAGVVNILPGSGRVVGERLSAHPDVKKIAFTGSTATGRHIMKVAADTVKKVTLELGGKSPNIVFADADLDKAVKNIAFGIFYNSGEVCCAGSRIYIQDTVYEEVLQKLKDYTESLKVGDPFDEEVFQGAQTSDKQLHKILDYVDVAKSEGARLVTGGARHGSKGYFVKPTVFADVKEDMRIVKEEVFGPIVTVSKFSTVDEVIAMANDSQYGLAAGIHTNDINKAVDVSKRVKAGTVWINTYNNFHQNVPFGGFGQSGIGREMGEAALSNYTQTKSVRIAIDKPIR
What is the function of this protein?
Minor mitochondrial aldehyde dehydrogenase isoform.  Plays a role in regulation or biosynthesis of electron transport chain components.  Involved in the biosynthesis of acetate during anaerobic growth on glucose (By similarity).
What are the official names of this protein?
Aldehyde dehydrogenase 5, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: QUEF_METEP
Sequence: MDSIETHAKQLGQQTPLPASPEAAQLDRVPNPHADTDYLARFTAPEFTSLCPVTGQPDFATLVIDYVPDRWLVESKSLKLYLGAFRNHGAFHEDCTVGIGRRLVALLEPRWLRIGGYWYPRGGIPIDVFWQTGEPLKSVWLPDQGVAPYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_CLOBA
Sequence: MNDYLEIIDVVARQILDSRCFPTVEVEVYLEDGTMGRAAVPSGASTGMYEAVELRDGDKDKYLGKGVLTAVQNVNDTIAEALIGCNVFDQPYIDKMLIELDGTNNKGKLGANAILGVSLAVANAAANALGLSLYKYVGGVNAKVLPVPMMNIINGGSHADNSVDLQEFMIMPVGATSFTEALRMCAEVYHTLKNTLKDKGYATGLGDEGGFAPNLKSNAEAIDVIIEAITKAGYKAGEDMFIAIDAASSEYYKDGKYVLENEGKTLTSAEMVDFFEDWVNKYPIISIEDGMAEEDWDGWKLLNERLGKKVQLVGDDLFVTNTERLEKGIEIGAANSILIKLNQIGTLTETLNAIEMANRAGYTAVISHRSGETEDTTISDLVVAVNAGQIKTGAPARSERVAKYNQLLRIEEELEDVAEYRGKKAFFNIKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: AROC_METST
Sequence: MVANTTGEIFKVTTFGLSHGKALGATIDGCPAGLNLSNEDIQNELNKRRPGTSNLTTSRDEKDKVEILSGIFNGMTDGTPITAIIFNKDQRSKNYDNLKNNPRPGHGDFCWREKFGNYDYRGGGRGSGRVTIGHVIGGAVSKKLLQQHNITTTAHVTSIHNIHSTKKFTLNTIKENITKNNVRCADLEVATLMEDEILKLKERGDSTGGKVEIIIDNVPVGLGQPVFDKIDGDFAKALMNIGAVKAVEVGCGIESSTLTGHEMNDEYYIEDNKIQTKTNNAGGIVGGMTNGMPIILKISVKPTPSVSGIQNTVNLEKRENSTIEIEGRHDPCICPRITTVAEAVCNMVLADHMIRAGYIHPDKIN
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PYF_LOLVU
Sequence: YAIVARPRF
What are the official names of this protein?
Peptide tyrosine phenylalanine, Neuropeptide F-related peptide, PYF.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: CET2_TOBAC
Sequence: MGSKMSDPLVIGRVIGEVVDYFTPSVKMSVTYNSSKHVYNGHELFPSSVTSKPRVEVHGGDLRSFFTMIMIDPDVPGPSDPYLREHLHWIVTDIPGTTDCSFGKEIVGYEMPRPNIGIHRFVFLLFKQKKRQTVLTAPLSRDRFNTRKFAEENELGSPVAAVFFNCQRETAARRR
What is the function of this protein?
May form complexes with phosphorylated ligands by interfering with kinases and their effectors.
What are the official names of this protein?
CEN-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylethanolamine-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMF_ALCBS
Sequence: MKRQKRNKDDRAYNRGYNAGLDGKSREDCPFGTLQARTNWMGGWREGRTDFAHGMLGVASIQNLKNIG
What is the function of this protein?
During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes).
What are the official names of this protein?
Ribosome modulation factor, RMF.
What is the protein family that this protein belongs to?
Belongs to the ribosome modulation factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3635_BACCR
Sequence: MTKHDHGLKEKVEGTIDKVKGEVKEVVGKVTDNKKLQAEGKWDKVKGTAKDTVGNVKEKVHEYKEHKKEK
What are the official names of this protein?
UPF0337 protein BC_3635.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: RL9_XANC8
Sequence: MDLILLQKVTNLGNLGDKVSVKPGYGRNFLVPQGKAVPATAANVEAFETKRAEYEAKANTILADAQSRATKFEGASVTIGAHASTEGKLYGSVGPRDIAEAFTAAGLPLEKSEVILGEGAFRNVGEYDVVLHLHADVETTVKVIVESDA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RUVB_CLOBA
Sequence: MERIVTPAEMFEDGNSELSLRPQKINEYIGQDKVKERLNIFIKAAKNRKEALDHVLLYGPPGLGKTTLANIIAKEMTGDLKITSGPAIERAGDLAAILTTLKDYDVLFIDEIHRLNRSVEEILYPAMEDYALDIVIGKGAAAKSIRLDLPKFTLIGATTRIGMLTSPLRDRFGVLCAMEYYDENQLKEIVIRSAAVFGCKITEEGALEIASRSRGTPRIANRLLKRVRDYSEVKSNTVISLKEAREALELLEVDNQGFDKVDNKILEAIIDNFNGGPVGIETLSYFIGEELGTVEDVYEPYLLQKGFIVRTPRGRIASDKAYKHLGRVNNKNNNSNKGQTSFFK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RL19_BACMK
Sequence: MQQLITEITKGQLKTDLPSFRPGDTLRVHVKVVEGTRERIQLFEGVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPRIANIEVLRRGKVRRAKLYYLRNLRGKKARIKEIR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: SCW_DROME
Sequence: MLNVFFLTSLFYAASATTYVTTNNHIEMPIYQKRPLSEQMEMIDILDLGDRPRRQAEPNLHNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLDDDILISNEDRQEIASCNSILTFSSRLKPEQLDNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRANFTVSVYRKLDNRQDFSYRILGSVNTTSSQRGWLEFNLTDTLRYWLHNKGLQRRNELRISIGDSQLSTFAAGLVTPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPHLPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGCH
What is the function of this protein?
Part of the signal that specifies dorsal cell fates in the embryo.  Acts together with dpp.
What are the official names of this protein?
Protein screw.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL35_NOCSJ
Sequence: MPKNKTHSGASKRFRVTGSGKILREKAGKRHNLEKKASKVTRRMTGTTELAKADVKRAKKMLGL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RL6_ENTH1
Sequence: MSAPQWFVPVKAGDAKVPAYYPTDDMIQEQKKKLRTRKGAKITALDKPAWNLEKLRKSIVPGAILIIVAGKYAGKKVVFLKQCIKSGALIVTGPFKINGVPLMRINQRYVIATSQKVDVSKVDTTGVDVKFFKKIAIKKAAFGKTVEEDFAKKQYEAKKALIVEKQKQVDESIVAEIKKVPYLKEYMASYFTLKNGDHPHLLKF
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL6 family.
Protein: LOLB_PSEAB
Sequence: MRLRLFLAASALALLSGCAGLTSHEALEGQGDAQTWKTHKQQLSELDAWQIDGKVGIRAPRDSGSGTLFWLQRQGYYDIRLSGPLGRGAARLTGREGAVSLEVAGQGRYQAESPEALLEEQLGWRLPVSHLLWWVRGLPAPDSKSRLTLDADSRLARLEQDGWQIEYTRYAEQNGYWLPERLKLHGQDLDVTLVIKDWQPRQLGR
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: LGR5_RAT
Sequence: MDTSRVRMLLSLLALLQLVAAGSPPRPDTMPRGCPSYCHCELDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLPASLLHRLRFLEELRLAGNALTHIPKGAFAGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADHAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPERAFVGNPSLITIHFYDNPIQFVGISAFQHLPELRTLTLNGASQITEFPDLTGTATLESLTLTGAKISSLPQTVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKGGTFQQLFNLRSLNLARNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHLKLTGNRALQSLIPSANFPELKIIEMPYAYQCCAFGGCENVYKIPNQWNKDDSSSVDDLRKKDAGLFQVQDERDLEDFLLDFEEDLKVLHSVQCSPPPGPFKPCEHLFGSWLIRIGVWTTAVLALSCNALVAFTVFRTPLYISSIKLLIGVIAVVDILMGVSSAILAVVDTFTFGSFAQHGAWWEGGIGCQIVGFLSIFASESSVFLLTLAALERGFSVKCSSKFEMKAPLSSLKAIILLCVLLALTIATVPLLGGSEYNASPLCLPLPFGEPSTTGYMVALVLLNSLCFLIMTIAYTRLYCSLEKGELENLWDCSMVKHTALLLFTNCILYCPVAFLSFSSLLNLTFISPEVIKFILLVIVPLPACLNPLLYIVFNPHFKEDMGSLGKQTRFWTRAKHPSLLSINSDDVEKRSCDSTQALVSFTHASIAYDLPSDSGSSPAYPMTESCHLSSVAFVPCL
What is the function of this protein?
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle.  Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.  In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal.  Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development (By similarity).
What are the official names of this protein?
Leucine-rich repeat-containing G-protein coupled receptor 5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state.