PharMolix/UniProtQA huggingface dataset:
Protein: SAP_HUMAN
Sequence: MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
What is the function of this protein?
Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
What are the official names of this protein?
Prosaposin, Proactivator polypeptide.
Protein: TIPM_LAMBD
Sequence: MKTFRWKVKPGMDVASVPSVRKVRFGDGYSQRAPAGLNANLKTYSVTLSVPREEATVLESFLEEHGGWKSFLWTPPYEWRQIKVTCAKWSSRVSMLRVEFSAEFEQVVN
What is the function of this protein?
Part of the distal tail tip which plays a role in DNA ejection during entry, and in tail assembly initiation during exit.  May bind tail tip complex associated with tape measure protein and allow tail tube protein polymerization on top of tail tip.
What are the official names of this protein?
Tail tip protein M.
What is the protein family that this protein belongs to?
Belongs to the lambda-like tail tip protein M family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: TXC1A_CUPSA
Sequence: GFGALFKFLAKKVAKTVAKQAAKQGAKYVVNKQME
What is the function of this protein?
Has antimicrobial activity against B. subtilis, E. coli, E. faecalis, P. denitrificans, P. aeruginosa, P. putida, S. aureus, and S. epidermidis.  Shows insecticidal and hemolytic activities.  Probably acts by disturbing membrane function with its amphipathic structure.  Synergistically increases the insecticidal activity of CSTX-1 (AC P81694), CSTX-9 (AC P58604), and CSTX-13 (AC P83919) by up to 65% (PubMed:15914655).  Also inhibits the formation of nitric oxide by neuronal nitric oxide synthase.
What are the official names of this protein?
Cupiennin-1a, Cu-1a, M-ctenitoxin-Cs1a, M-CNTX-Cs1a.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NDK_HERAR
Sequence: MAIERTLSIIKPDAVAKNVIGQIYSRFEGAGLKIIAARMAQLSRAEAEGFYAVHSARPFFKDLVDFMISGPVMIQVLEGENAIAKHRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAEETAKVEIAYYFPALNVYSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCTN2_MOUSE
Sequence: MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELSSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSSKGSSGGKATAGAPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYETIQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRENLATVEGNFASIDARMKRLGK
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.  In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity).  Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.  Involved in anchoring microtubules to centrosomes.  May play a role in synapse formation during brain development (PubMed:14983524).
What are the official names of this protein?
Dynactin subunit 2, 50 kDa dynein-associated polypeptide, Dynactin complex 50 kDa subunit, DCTN-50, Growth cone membrane protein 23-48K, GMP23-48K, p50 dynamitin.
What is the protein family that this protein belongs to?
Belongs to the dynactin subunit 2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
Protein: PLSB_SHISS
Sequence: MTFCYPCRAFALLTRGFTSFMSGWPRIYYKLLNLPLSILVKSKSIPADPAPELGLDTSRPIMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGTLLPRYVFIHGGPRVFTYYTPKEESIKLFHDYLDLHRSNPNLDVQMVPVSVMFGRAPGREKGEVNPPLRMLNGVQKFFAVLWLGRDSFVRFSPSVSLRRMADEHGTDKTIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASRAIAKAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRLYQGINVHNAERVRQLAHDGHELVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLIPIYIGYEHVMEVGTYAKELRGATKEKESLPQMLRGLSKLRNLGQGYVNFGEPMPLMTYLNQHVPDWRESIDPIEAVRPAWLTPTVNNIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTEQLNCYLDLMRNVPYSTDSTVPSASASELIDHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLVLPSLMAAIVTQHRHISRDVLMEHVNVLYPMLKAELFLRWDRDELPDVIDALANEMQRQGLITLQDDELHINPAHSRPLQLLAAGARETLQRYAITFWLLSANPSINRGTLEKESRTVAQRLSVLHGINAPEFFDKAVFSSLVLTLRDEGYISDSGDAEPAETMKVYQLLAELITSDVRLTIESATQGEG
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GCH1_STRGC
Sequence: MSDFEKLQETVYQLLELVGENPDREGLLDTPKRVAKMYQEVFSGLGRDPKDEFTAVFSEGHEEVVLVKDIPFHSMCEHHLLPFYGVAHVAYLPSNGKVTGLSKLARAVEVASKRPQLQERLTAQIATALDEALSPEGVFVMVEAEHMCMTMRGIKKPGSKTITTVAKGIYKENVHQRQEILSMIHHD
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: MLTF_YERP3
Sequence: MTRIKLSYFTIGLVALLLALALWPNIPWRNGQEGQLDQIKARGELRVSTISSPLIYSTEKDTPSGFDYELAKRFADYLGVKLVIIPHHNIDDLFDALDNDDTDLLAAGLIYNRERLNRARTGPAYYSVSQQLVYRLGSPRPKSFSDLKGQVVVASGSAHMTTLKRLKQTKYPELNWSSSVDKSGKELLEQVAEGKLDYTLGDSATIALLQRIHPQLAVAFDVTDEEPVTWYFKQSDDDSLYAAMLDFYSEMVEDGSLARLEEKYLGHVGSFDYVDTKTFLSAIDNVLPSYQHLFEKHAGDIDWKLLAVIAYQESHWNPQATSPTGVRGLMMLTRATADGLGVKDRVDPEESIRGGAIYLQRLMKKLPETIPEDERIWFALAAYNLGYGHMLDARRLTKNQNGNPDSWVDVKMRLPMLSQKRYYPSTTYGYARGHEAYNYVENIRRYQVSLVGYLQEKEKKAAQHAAIEAELGKSNPVVGPGWSIGD
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: TAAR5_RAT
Sequence: MRAVLLPGSGEQPAAFCYQVNGSCPRTVHPLAIRVLIYLACAVGMLITVLGNLFVVFAVSYFKVLHTPTNFLLLSLALADMLLGLLVLPLSTVRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRIALRYIAAGWGIPAAYTAFFLYTDVVERALSQWLEEMPCVGSCQLLFNKFWGWLNFPAFFIPCLIMISLYLKIFVVATRQAQQIRTLSQSLSGAVKRERKAAKTLGIAVGIYLVCWLPFTVDTLVDSLLNFVTPPLVFDIFIWFAYFNSACNPIIYVFSYRWFRKALKLLLSREILSPRTQTADLFHD
What is the function of this protein?
Olfactory receptor specific for trimethylamine, a trace amine.  Also activated at lower level by dimethylethylamine.  Trimethylamine is a bacterial metabolite found in some animal odors, and is a repulsive odor associated with bad breath and spoiled food.  This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity).
What are the official names of this protein?
Trace amine-associated receptor 5, TaR-5, Trace amine receptor 5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RUVB_MAGSA
Sequence: MTSRVVSPEQNPNDAEMSLRPQSLDDFVGQRQVCENLKVFISAARARGEALDHVLFHGPPGLGKTTLAQIMARELGVGFRATSGPVIQRAGDLAALLTNLEPRDVLFIDEIHRLNPAIEEVLYPAMEDFQLDLIIGEGPAARSVRIELPPFTLVGATTRSGLLTTPLRERFGIPCRMNFYEPAELEAIVSRGARVLGFALTPDGAAEVARRSRGTPRVAGRLLRRVRDFAVVAGRSPVDALVADAALNRLEVDRIGLDAMDRRYLRCIAENYGGGPVGVETLAAALSESRDTLEEVVEPYLLQQGMIQRTPRGRMLSASGFKHIGLNPPKDLLVQLDLLTRMDEEGE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: YOJM_BACSU
Sequence: MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHHVQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAGGPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDGSAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ
What are the official names of this protein?
Superoxide dismutase-like protein YojM.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: LIPL_MYCTU
Sequence: MMVDTGVDHRAVSSHDGPDAGRRVFGAADPRFACVVRAFASMFPGRRFGGGALAVYLDGQPVVDVWKGWADRAGWVPWSADSAPMVFSATKGMTATVIHRLADRGLIDYEAPVAEYWPAFGANGKATLTVRDVMRHQAGLSGLRGATQQDLLDHVVMEERLAAAVPGRLLGKSAYHALTFGWLMSGLARAVTGKDMRLLFREELAEPLDTDGLHLGRPPADAPTRVAEIIMPQDIAANAVLTCAMRRLAHRFSGGFRSMYFPGAIAAVQGEAPLLDAEIPAANGVATARALARMYGAIANGGEIDGIRFLSRELVTGLTRNRRQVLPDRNLLVPLNFHLGYHGMPIGNVMPGFGHVGLGGSIGWTDPETGVAFALVHNRLLSPLVMTDHAGFVGIYHLIRQAAAQARKRGYQPVTPFGAPYSEPGAAAG
What is the function of this protein?
Shows both esterase and beta-lactamase activities, with a much higher activity against phenyl esters than against beta-lactams (PubMed:26398213, PubMed:26672466).  Shows esterase activity against both long-chain and short-chain p-nitrophenol (pNP) esters, with a preference for shorter chain esters (PubMed:26398213, PubMed:26672466).  Hydrolyzes substrates containing beta-lactam ring such as nitrocefin and ampicillin (PubMed:26672466).  Functions as an immunogen that activates both humoral and cell-mediated responses (PubMed:26398213).
What are the official names of this protein?
Esterase/beta-lactamase LipL.
What is the protein family that this protein belongs to?
Belongs to the beta-lactamase family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cell membrane.
Protein: LEUC_CAMC1
Sequence: MKQTITEKIFSDHVGKEVSAGEIIESKIDMIIGNDITTPISIKQFERSGAKKLANPDGFAIVMDHYIPTKDILSANQAKISREFAYKHDLKNYFDEKDMGIEHAILPEKGLVIPGDVIIGADSHTCTHGALGAFSTGMGSTDLAYAMITGKNWFKVPESIKVVFKGKLDKHVYGKDLILEIIRQIGVDGALYKALEFSGEVIDGLSMDDRFSMCNMAIEAGAKSGIIAVDEITKEFLKDKNLRDKPKFFYSDEGAKYDKILEIDVTNLDPVIAYPFLPSNGKSVRQAVRDDLAIDQAFIGSCTNGRLSDLRIAAQILKGKKVARKTRLIITPATQKIARAAEKEGLIDIFIEAGAVVSNPTCGACLGGYMGILGANERCISTTNRNFVGRMGDRTSEIYLANSAVVAASAIAGKIADPRDL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: PSBB_ARAHI
Sequence: MGLPWYRVHTVVLNDPGRLLSVHIMHTALVAGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWNITGGTITNPGLWSYEGVAGAHIVFSGLCFLAAIWHWVYWDLEIFCDERTGKPSLDLPKIFGIHLFLSGVACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQPVNPAWGVEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVSAGLAENQSVSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAVGWLGHPVFRNKEGRELFVRRMPTFFETFPVVLVDGDGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPATVKKYARRAQLGEIFELDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGAFQKLGDPTTKRQAV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PAL3_PETCR
Sequence: MAYVNGTTNGHANGNGLDLCMKKEDPLNWGVAAEALTGSHLDEVKRMVAEYRKPVVKLEGETLTISQVAAISARDDSGVKVELSEEARAGVKASSDWVMDSMNKGTDSYGVTTGFGATSHRRTKQGGALQKELIRFLNAGIFGSGAEAGNNTLPHSATRAAMLVRINTLLQGYSGIRFEILEAITKFLNHNITPCLPLRGTITASGDLVPLSYIAGLLTGRPNSKAVGPTGVTLSPEEAFKLAGVEGGFFELQPKEGLALVNGTAVGSGMASMVLFEANILAVLAEVMSAIFAEVMQGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSAYVKAAQKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRSSTKMIEREINSVNDNPLIDVSRNKAIHGGNFQGSPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSGGRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISSRKTSEAVEILKLMSTTFLVGLCQAIDLRHLEENLKSTVKNTVSQVAKRVLTMGVNGELHPSRFCEKDLLRVVDREYIFAYIDDPCSATYPLMQKLRETLVEHALNNGDKERNLSTSIFQKIAAFEDELKALLPKEVETARAALESGNPAIPNRIKECRSYPLYKFVREELGTEYLTGEKVRSPGEEFEKVFTAMSKGEIIDPLLECLESWNGAPLPIC
What is the function of this protein?
This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
What are the official names of this protein?
Phenylalanine ammonia-lyase 3.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UP07_FRUSA
Sequence: GSFFATPDDRH
What are the official names of this protein?
Unknown protein 7 from 2D-PAGE.
Protein: MENG_ANOFW
Sequence: MQQSKEERVHRVFEKISDHYDRMNSVISFKRHVAWRKDTMKRMNVQKGTKALDVCCGTADWTIALAEAVGPSGEVYGLDFSRNMLKVGEEKVKERGFQHVTLVHGNAMSLPFPDNTFDYVTIGFGLRNVPDYMTVLKEMYRVAKPGGKVVCLETSQPTLIGFRQLYYAYFRYIMPFFGKIFAKSYEEYSWLQESAREFPGMDELADMFRQAGFVNVQVKPYTFGVAAMHLGHKPDGR
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: PUP_MYCSK
Sequence: MAQEQTKRGGGGGEDDDLSGGAGAGQERREKLAEETDDLLDEIDDVLEENAEDFVRAYVQKGGQ
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: PRPB_CUPNE
Sequence: MTYSASDLARSAGARFRQALADEHPLQVVGTINANHALLAKRAGYRAIYLSGGGVAAGSLGLPDLGISNLDDVLTDIRRITDVCDTPLLVDVDTGFGASAFNVARTTKSLIKFGAAAMHIEDQVGAKRCGHRPNKEIVTQGEMVDRIRAAVDARTDENFVIMARTDALAVEGLDKAIERAVACAEAGADAIFPEAMTDLAMYRKFVDAVKVPVLANITEFGATPLFTTEELDGAGVSMVLLPLSAFRAMNKAAENVYAAIRQDGTQKNVVDTMQTRAELYESIGYHDFEQKLDALFAQGKGK
What is the function of this protein?
Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route).  Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
What are the official names of this protein?
2-methylisocitrate lyase, 2-MIC, MICL, (2R,3S)-2-methylisocitrate lyase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
Protein: G6P_BPIKE
Sequence: MPALLGIPALIRFIMGLVPIAIGYFAKFLGMIITRNGLMASALIGAILSVVSFSIQLLGDALSSSMGGISADFGNLMSSVLPDGTTTCITVIITTRIAVFVFDIKDRLLGIANKVI
What is the function of this protein?
Plays essential roles both in the entry of the viral genome into the bacterial host and in budding process.  The formation of the G3P-G6P complex termed adsorption complex is essential for correct termination of filamentous phage assembly (By similarity).
What are the official names of this protein?
Head virion protein G6P, Coat protein D, G6P.
What is the protein family that this protein belongs to?
Belongs to the inovirus G6P protein family.
What are the subcellular locations of this protein?
Virion. Host membrane; Multi-pass membrane protein. Note=Prior to assembly, G6P is found associated with the bacterial host inner membrane. There are about five copies of G6P in the mature virion. They are located together with G3P at the head side of the filamentous virion (By similarity).
Protein: CRBN_DANRE
Sequence: MGNQLQLLPENEEEEEDDMETEDRDGEDVEKPSIINFDTSLPTSHAYLGSDMEEFHGRTLHDEDSVQNLPVLPHVALILIPGQTLPLQLFRPQEVSMFRNLVSQDRTFAVLAHSPDPSGTETKAEFGTTAEIYAFREEQEYGIETVKIKAVGRQRFRVHDIRTQADGIRQAKVQILPERILPDPLCALQFLPRLHTHSPQTKHTQTTPPQKRCSQNYRQKKLHCASMTSWPPWVYSLYDSKTLMSRVKKQLHEWDENLKDESLPTNPTDFSYRVAACLPIDDALRLQLLKIGSAIQRLRCELDIMDRCTSLCCKQCQDTEITSKNEIFSLSLYGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTLHSWFPGYAWTIAQCRTCSSHMGWKFSAVKKDLSPPRFWGLTRSALLPTIPQGEEGVEGSRLLCL
What is the function of this protein?
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable).  Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed:20223979).  Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons.  Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity).  May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity).
What are the official names of this protein?
Protein cereblon, zcrbn.
What is the protein family that this protein belongs to?
Belongs to the CRBN family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DCS_CURLO
Sequence: MEANGYRITHSADGPATILAIGTANPTNVVDQNAYPDFYFRVTNSEYLQELKAKFRRICEKAAIRKRHLYLTEEILRENPSLLAPMAPSFDARQAIVVEAVPKLAKEAAEKAIKEWGRPKSDITHLVFCSASGIDMPGSDLQLLKLLGLPPSVNRVMLYNVGCHAGGTALRVAKDLAENNRGARVLAVCSEVTVLSYRGPHPAHIESLFVQALFGDGAAALVVGSDPVDGVERPIFEIASASQVMLPESAEAVGGHLREIGLTFHLKSQLPSIIASNIEQSLTTACSPLGLSDWNQLFWAVHPGGRAILDQVEARLGLEKDRLAATRHVLSEYGNMQSATVLFILDEMRNRSAAEGHATTGEGLDWGVLLGFGPGLSIETVVLHSCRLN
What is the function of this protein?
Catalyzes the formation of feruloyldiketide-CoA by condensing feruloyl-CoA and malonyl-CoA in the curcuminoid biosynthesis.  Has no activity with cinnamoyl-CoA.
What are the official names of this protein?
Phenylpropanoylacetyl-CoA synthase, Diketide CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: VE6_HPV45
Sequence: MARFDDPKQRPYKLPDLCTELNTSLQDVSIACVYCKATLERTEVYQFAFKDLCIVYRDCIAYAACHKCIDFYSRIRELRYYSNSVYGETLEKITNTELYNLLIRCLRCQKPLNPAEKRRHLKDKRRFHSIAGQYRGQCNTCCDQARQERLRRRRETQV
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation.  In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development.  The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).  The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization.  Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis.  E6 also inhibits immune response by interacting with host IRF3 and TYK2.  These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: RL24E_THEGJ
Sequence: MARWNVCSYCGREFEPGTGKMFVRNDGRVLFFCSSKCEKLYFMGRNPRKLKWTKAFQEARLQRAKRRK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
Protein: DAPB_PELPB
Sequence: MRFTLVGNGRMGQQVALVIAQSGCHETAAVLDINTAITPDLFQGSDAIIDFTVREAFFANLPAMLESGVPIVVGTTGWDDLRDEIEVKVSDAGASLLYSANFSLGVNIFLRTVREAARLIAPFGQFDIAFAEQHHTAKADFPSGTALRAADMILSANSRKKSVVRQLSDDKKLAPDELQVASLRLGSVFGKHSAFIDSDADEIVISHTAKSRSGFAAGAVEAAIWLARRHTTAPGFYTMDDFLNETFS
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.