PharMolix/UniProtQA huggingface dataset:
Protein: LIPL_PAPAN
Sequence: MESKALLLLALAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
What is the function of this protein?
Key enzyme in triglyceride metabolism (By similarity).  Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (By similarity).  Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity).  Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity).  Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity).
What are the official names of this protein?
Lipoprotein lipase, LPL, Phospholipase A1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Secreted, extracellular space, extracellular matrix. Note=Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells. Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non- coated endocytic vesicles.
Protein: DCTA_YERPA
Sequence: MKVSIFKTLYFQVLTAITIGVLLGHFYPEIGAQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAIALLYFEIVSTLALLIGLVVVNVAQPGVGMNIDPATLDAKAVALYAEQASQQGIIPFLLDIIPGSVVGAFASGNILQVLLFAVLFGFALHRLGEKGQLIFNVIESFSRVIFGVINMIMRLAPLGAFGAMAFTIGKYGVGSLVQLGQLILCFYLTCILFVVLVLGTIAKFNGFNIFKFIRYIKEELLIVLGTSSSESVLPRMLDKMENAGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTHMDIMHQVTLLVVLLLSSKGAAGVTGSGFIVLAATISAVGHLPLAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWCKQLDNDQLQAVLSNKVLPNVKSSVSVS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CCA_PSEMY
Sequence: MQIYKVGGAVRDRLLGRPVSEVDWVVVGASAEQMLELGYRPVGADFPVFLHPQTGEEYALARTERKSGRGYGGFTFHASPEVTLEEDLIRRDLSVNAMAEDEQGKLIDPYGGQQDLAARILRHVSPAFAEDPLRVLRVARFAARYAPLGFHVADETLGLMRQLAESGELAHLTAERSWKEISRALMEPRPDVFIQVLRDCGALAALLPEVDDLFGVPQPEAHHPEIDTGVHVLSVLRQCAEHDQPLSVRWACLLHDVGKGLTPEAEWPRHIAHEHKGLRLIQAINERCKAPRDCAELAMLVGEFHTHGHRALELRPSTLLELLQRFDVFRRPQRFAEFVAACEMDARGRHGLEQRQYPQAAYLLGAAEAARQVPVKPLLEKGLKGAELGEALNRERLRALKAYKAQHAPS
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: RNH1_YEAST
Sequence: MARQGNFYAVRKGRETGIYNTWNECKNQVDGYGGAIYKKFNSYEQAKSFLGQPNTTSNYGSSTHAGGQVSKPHTTQKRVHRRNRPLHYSSLTSSSACSSLSSANTNTFYSVKSNVPNIESKIFNNWKDCQAYVKHKRGITFKKFEDQLAAENFISGMSAHDYKLMNISKESFESKYKLSSNTMYNKSMNVYCDGSSFGNGTSSSRAGYGAYFEGAPEENISEPLLSGAQTNNRAEIEAVSEALKKIWEKLTNEKEKVNYQIKTDSEYVTKLLNDRYMTYDNKKLEGLPNSDLIVPLVQRFVKVKKYYELNKECFKNNGKFQIEWVKGHDGDPGNEMADFLAKKGASRR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
Protein: SYT_LATSS
Sequence: MAEIQLTFPDGAQKTFEQATSLLDVAKSISTSLAKKAIAGKFNGEVVDLQQPLLEDGAIEIITKDDQAVNLTATWHTAAFVLAATLSQHYPEMQFGEVTATEDGFYYDTDNEAGQVAVTDLPEIKTEMAKLIQSGEAISRVSVSKDDAKKLFAGQTYKLALLDEVEADQVLVYQLGDYSDFSLAPMLGKVSDVKFFELLSVAGAYWQGKSSNQMLQRIYGTAYPKQEELDADLKRRQEAKERDHRVIGNQLDLFFVDPKVGAGLPYWLPNGATIRRSIERYIIDKEVANGYEHVYTPILANLDLYKQSGHWDHYREDMFPPMDMGDGEMLELRPMNCPSHIQVYKHHPRSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVRPDQIQDEFKSILGLMIDVYADFNINDYTFRLSYRDPANTEKYFDDDEMWNKAQAMLKGAMDDLGLDYVEAEGEAAFYGPKLDVQTKTAMGNEETLSTIQLDFMLPERFDLHYVGEDGEMHRPVMIHRGLVSTMERFTAYLTEIYKGAFPTWLAPTQAVIIPVKNDLHYDYAKNIKDEMIKRGLRVRIDDRNEKMGYKIREAQTSKIPYTLVVGDQELAQATVSVRKYGEENAVEEASDMFINAIVAEVGNYSRDGKQHTKKINL
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENH3_HUMAN
Sequence: MILAGRAPSNTSTLMKFYSLLLYSLLFSFPFLYHPLPLPSYLHHTINLTHSLPAASNPSLANNCWLCISLSSSAYIAVPTLQTDRATSPVSLHLRTSFNSPHLYPPEELIYFLDRSSKTSPDISHQPAAALLHIYLKNLSPYINSTPPIFGPLTTQTTIPVAAPLCISRQRPTGIPLGNISPSRCSFTLHLQSPTTHVTETIGVFQLHIIDKPSINTDKLKNVSSNYCLGRHLPYISLHPWLPSPCSSDSPPRPSSCLLTPSPQNNSERLLVDTQRFLIHHENRTSSSMQLAHQSPLQPLTAAALAGSLGVWVQDTPFSTPSHPFSLHLQFCLTQGLFFLCGSSTYMCLPANWTGTCTLVFLTPKIQFANGTKELPVPLMTLTPQKRVIPLIPLMVGLGLSASTIALSTGIAGISTSVTTFRSPSNDFSASITDISQTLSVLQAQVDSLAAVVLQNRRGLGLSILLNEECCFYLNQSGLVYENIKKLKDRAQKLANQASNYAESPWALSNWMSWVLPILSPLIPIFLLLLFGPCIFHLVSQFIQNRIQAITNHSI
What is the function of this protein?
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain.  The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
What are the official names of this protein?
HERV-H_2q24.1 provirus ancestral Env polyprotein, Env protein HERV-H/p59, Envelope polyprotein, HERV-H/env59.
What is the protein family that this protein belongs to?
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I H env subfamily.
What are the subcellular locations of this protein?
Virion. SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane; Single-pass membrane protein.
Protein: RS4_ECO7I
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RGLA_ASPFU
Sequence: MLSKATLLLFLPSWARVTYAAFGITTTSSSYVIDANSPNPLKFTVNRSNCDITSINFYGAELQYQGTGSHIGSGLGSASVSATQSGDYIKVTCSTSTLTHYFVVHNGDPIIHMATYITAEPSIGELRFIARLNNELLPNEEPFGEVSNTSGGTAIEGSDVFLVNGQTRSKFYSSERFIDDHRHCVSGSAHRVCMILNQYESSSGGPFHRDINTNNGGQYNALYWYMNSGHVQTEANRMGLHGPYSMYFSRSGTPGTNIDTSFFANLDIQGYVPDSARGKVSGKASGADSTFKWVVHWYNDEAQYWTYTASDGSFTSPAMKPGTYTMVYYQGEYKVASTSVSVSAGSTTTKNISGSVTTGKTIFKIGEWDGQPTGFRNAANQLRMHPSDSRMSSWGPLTYTVGSSSLSDFPMAIFKSVNSPVTIKFTASSSQTGAATLRIGTTLSFAGGRPQVTVNSWTGPIPSAPKDLNSRGVTRGAYRGLGEVYDVAIPAGTIVAGTNTITISVVSGSSGDAFLSPNFIFDCVELFQ
What is the function of this protein?
Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Degrades the rhamnogalacturonan I (RG-I) backbone of pectin (By similarity).
What are the official names of this protein?
Probable rhamnogalacturonate lyase A.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 4 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YS13_CAEEL
Sequence: MGVEISLDPPVCPIQANGGVSKHKMINHCDKILAFKVKSSNNSNYSVNLIYGILKVCDVKELVITRKPGKPQADKLIIQYCMVEDENADPKPLFANGVPPGELSGETVIKLSAAE
What are the official names of this protein?
Uncharacterized protein ZK1307.3.
Protein: AROA_ACIF5
Sequence: MTRYLVRPGSRLAGRFPVPGDKSISHRAVILGALAEGVTEVEGLLEGADVLATIAAFRSMGVQMEGPDKGHLRIHGAGLQGLRAPVVPLDCGNSGTAMRLLAGVLAGQPFPSTLVGDASLQKRPMGRILNPLRAMGAEIAAQDGRAPLHIHGRPLHGIDYALPVASAQVKSAVLLAGLYADGQTCVTEPAPTRDHSERMLQGFGQPVERHGPRACLRGGGRLCGQALQVPGDISSAAFFLLGATIAPGSDLTLEGVGINPTRTGIIEILTRMGARIDLTALREVGGEPVADIRVRYAPLQGIAIPPRLVPLAIDEFPALFIAAACAKGQTVITGAEELRVKESDRIAVMAGGLRALGATVEERVDGAIISGSALLGGRVDSHGDHRIAMAFAMAALVAQGDMEILDCANVATSFPSFPALAQQAGLLLEVASA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAA_ARCFU
Sequence: MLKDEYGRVVTNLRIAVTKKCNLRCFYCHKEGESNPGEEISAERIVEIARAFKELGVRKLKITGGEPLLRKDLPDIILNLPEFEEISMTTNGILLEKYAEELRECGLSRVNVSLDTLDAEKYRWITGGGEVQKVVNGIEKACEVGLTPVKINMLVLGGVNDNEVDELLEFTNSFNRGNTKAILQVIELVPFPGFEKYFFDISTIEEKYARMATQRRVRAMHRRTQYFTPKGVIEFVKPMDNTAFCMHCNRMRVTSDGKLKPCLLRNETITIDGKHGEELARAIIETVRKREPYFKG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
Probable GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: PROF_BRABE
Sequence: MSWQQYVDQHLVATQCVTMAAICGLDGSIWAKSNGLELSQDEVATLARSFSKDEVLAANGIRIGGTKYIYLSGDDKLIRGKKDRQGVHIVKTKTAMVMALYAEPILPEQCAVVVEKLGDWLIQNDL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: FOSX_LISIN
Sequence: MISGLSHITLIVKDLNKTTTFLEEIFDAEEIYSSGDDTFSLSKEKFFLIAGLWICIMEGESLQERTYNHIAFQIQAEEMDEYIERIKSLGMEIKPERSRVKGEGRSVYFYDYDNHLFELHAGTLEERLKRYHK
What is the function of this protein?
Catalyzes the hydration of fosfomycin.
What are the official names of this protein?
Fosfomycin resistance protein FosX.
What is the protein family that this protein belongs to?
Belongs to the fosfomycin resistance protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LECA_LATOD
Sequence: VTSYTLNEVVPLKDVVPEWVRIGFSATTGAEFAAHEVLSWSFHSELGGTSGSQK
What are the official names of this protein?
Lectin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: PHO15_ARATH
Sequence: MKFGKEFSSQMVPEWHEAYMDYDYLKSQLKEIIKFKRKTNPHGPHHHHHHLLHRKMTLHRAFSGLISTSPKKKKHHGHGGGHGGGHQIGHFSDSDDDIEEGIKHVTAPILINSASHGYETTFLMASEEGGEYETVFFRRLDDEFNKVEKFYKEKVEEVMKEAVMLEKQMDALIAFRVKVEHPDGWPWEERTVEMTQLASDVANSAAAVAASTPAGARSMKVGAQAHMEAIQEGGSSKAGKSSDEEDDDDAEKEEDNGVSGEVSGDVRKMKAGRPPPIEVLDRVKFNHTKETPRSTIKSVLQASNLTELKFSRENLRKVEAKLRRAFVEFYQKLRLLKSYSFLNELAFSKILKKYDKITSRHASKSYMKMIDNSYLGSSDEVTRLVERVEATFIKHFSNANRSKGMNILRPKAKRERHRITFSTGFLGGCLFSLVVALFAIIRTRNILQEEGQKQYMNTMFPLYSLFGFVVLHILMYAGNIYYWRRYRVNYSFIFGFKHGTELGYRQVLFVGLSIGVFALLCILANLDMEVDPETKDYQALTELLPLFLLTGMFVVLVLPFNIFYRSSRFFFLTCLFHCLAAPLYKVTLPDFLVGDQLTSQVQALRSIQFYICHYGWGDYKHRINTCTESDAYNAFLFIVAVIPYVSRLLQCLRRLFEEKNPEQGYNGLKYFLTIVAVCLRTTYSVDEDNQFIWRILAGIFSAIAAIFCTYWDLVYDWGLLNRTSKNPWLRDKLLVPQKKVYFIAMILNILLRFAWLQTVLDFNFSFMHRQTMVAVVASLEIIRRGIWNFFRLENEHLNNVGKYRAFKTVPLPFNYDEDDDKGN
What is the function of this protein?
May transport inorganic phosphate (Pi).
What are the official names of this protein?
Phosphate transporter PHO1 homolog 5, Protein PHO1 homolog 5, AtPHO1;H5.
What is the protein family that this protein belongs to?
Belongs to the SYG1 (TC 2.A.94) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RF1_CHLMU
Sequence: MEVKVLECLRRLEEVEKLISDPNIFSNPKEYSSLSKEHARLSEIKNAHESILAAKKILHDDKLALSTEKDPEMIAMLEEGIQGGEESLERLSKQLENLLIPPDPDDDLSVIMELRAGTGGDEAALFVGDCVRMYHLYASIKGWQCEVLSASESDLGGYKEYIMGVSGTSVKRFLQYEAGTHRVQRVPETETQGRVHTSAVTIAVLPEPAEDDEEVFIDEKDLRIDTFRSSGAGGQHVNVTDSAVRITHIPTGVVVSCQDERSQHKNKAKAMRVLKARIRDAEVQKREQEASAMRSAQVGSGDRSERIRTYNFPQNRVTDHRIGLTLYNLDRVMQGELDMITTALVSHAHRQLFGHEETN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEEP_EUBCE
Sequence: MKNEVVYKQLTEKILPFWNAMRDDENGGFYGYMSEDLHIDDHADKGCILNSRILWFYSTAYMYLQDEKLLDNAKHAFEFLKTYCFDPMCGGIFWSVRYNGKPADTTKHTYNQAFAIYALSAYYEATGSIEAIAIAEIIYEKIEDTMRDTKGYLEAFTRDFRPADNDKLSENGVMAERTMNTLLHIIEAYSALVHALRKKVADPAKGDVRDELFMNVVENKLAAALELMRDKFYNSDRHRLDVFFDKEYESLIDLTSYGHDIEASWLLEWAAGILDDEEITESLHPISSDLVEKVYKEAFDGHSIVNECEDGDVNTDRIWWVEAESVLGFLKAFEREGKEEYRKAAHEILAFILDKQVDKREGSEWFEMLKEDGTPCHKPMVREWKCPYHNGRMCLEILKSGIEIG
What is the function of this protein?
Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man).  Can also epimerize lactose to epilactose.
What are the official names of this protein?
Cellobiose 2-epimerase, CE.
What is the protein family that this protein belongs to?
Belongs to the cellobiose 2-epimerase family.
Protein: CK2N1_MOUSE
Sequence: MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQSKRPPKLGQIGRSKRVVIEDDRIDDVLKTMTDKAPPGV
What is the function of this protein?
Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity).  Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (PubMed:28642476).  Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity).  Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (PubMed:33746041).  Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (PubMed:31327268).
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase II inhibitor 1, calcium/calmodulin-dependent protein kinase II inhibitor alpha, mCaMKIINalpha.
What is the protein family that this protein belongs to?
Belongs to the CAMK2N family.
What are the subcellular locations of this protein?
Synapse. Cell projection, dendrite. Postsynaptic density.
Protein: FKBX_ECOLI
Sequence: MSESVQSNSAVLVHFTLKLDDGTTAESTRNNGKPALFRLGDASLSEGLEQHLLGLKVGDKTTFSLEPDAAFGVPSPDLIQYFSRREFMDAGEPEIGAIMLFTAMDGSEMPGVIREINGDSITVDFNHPLAGQTVHFDIEVLEIDPALEA
What is the function of this protein?
PPIases accelerate the folding of proteins (Probable).  Substrate specificity investigated with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide' where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln (PubMed:9188461).
What are the official names of this protein?
FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
Protein: HIS2_PSEU2
Sequence: MTDTLSRLAEVLESRKDAAADSSYVASLYHKGLNKILEKLGEESIETIIAAKDAAVSGNCSDVIYETADLWFHSMVMLAALGQHPQAVLDELDRRFGLSGHAEKAARTAE
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPO_HUMAN
Sequence: MEQANPLRPDGESKGGVLAHLERLETQVSRSRKQSEELQSVQAQEGALGTKIHKLRRLRDELRAVVRHRRASVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKLTSRGVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSLCEYLNAYSGRKYQADRLQSDFAALLTGPLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYKDLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMSLVS
What is the function of this protein?
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.  Modulates the kinetochore-bound levels of NDC80 complex.
What are the official names of this protein?
Centromere protein O, CENP-O, Interphase centromere complex protein 36.
What is the protein family that this protein belongs to?
Belongs to the CENP-O/MCM21 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Protein: TE2IP_DANRE
Sequence: MSKKKEASKISPVLFLDPGGQSMRFYVRPGPTKMQLHPLITSGGGNLCRNQEPGAILLIDPTDATNVTQNTGQKYISTKYILDCVEQNQQLDPNDYAIIIGPSVQTRMALRNQGSGRLGYSSEEDAAILKFIEKRQQDAKGNLVWKEMEKRHVTEHSWQSMKDRFLKHLQQKLADKPTKKSPIKRKPLSFTQSPLRKKKVVEISEDESVQKGDCPEAPMATETGSINPPASPERASSPPEEPQAAGQPSQASSNDSQDETCVLVIETPESENPRLDEDAPDASNEHSSLKKKRRKTCKTSTTDSRSSRLEEDPVGQDIPDESNAQSSPKKKRQKACKTSTTDSRSSRLEENPDRRDIPDESTEQSSPNKSQMTSKISTSDSGNPIGDQGCDNPHGCNANSSPSKTRQTNSEASTPDSKKLGILAKAAKEFEDSDVMDDSEECENPCEVPIAEPSDAQESSATPATLVREPESQAEHHEETQPDSPMSEEERPGPSSAVVPPSLNSSTSCSHIRETPEETLSRDLLEVKEQVINLMRETKKDLVEVTKALLKASGDLKRAQVFLLNGYDHETHGPLWTRLDDETLLAADPYELEQLQSKFGEEEVTRRKSFLATDVK
What is the function of this protein?
Acts both as a regulator of telomere function and as a transcription regulator.  Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome).  Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2.  Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity).
What are the official names of this protein?
Telomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Repressor/activator protein 1 homolog, RAP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the RAP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: ESSB_STAAS
Sequence: MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHKGTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQTNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK
What is the function of this protein?
Component of the type VII secretion system (Ess).  Required for the secretion of EsxA and EsxB.
What are the official names of this protein?
Type VII secretion system protein EssB.
What is the protein family that this protein belongs to?
Belongs to the EssB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: FMT_PELTS
Sequence: MRVVFMGTPDFAVPSLKALVEAGHDVLAVVTQPDRPRGRGRKETPPPVKQAAHALNIPVFQPLKIKDADFTALLKKLSPQVIAVVAYGRIIPPDILTIPKYGCINVHASLLPKYRGAAPIHWAVINGEKETGITTMFMDEGLDTGDMILQEAVAITEEDTAGTVHDALAVLGARLLVQTLELVGQGMAPRVPQQGIPSYAPPLKTEDELIRWDRTARDIFNQIRGMNPWPGARTYFSGKVLKIWRAAVVEEEGAALKPGQVMSAGRNAIVVGTGRGRIAVTELQLQGARRLSAGDFLRGTPMPEGIVLGEACS
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: Y487_METS4
Sequence: MADTPSVEPTRIDPKLLELLVCPLTKGRLEYDSARQELISRSAKLAYPIRDGIPIMLPEEARPLAE
What are the official names of this protein?
UPF0434 protein M446_0487.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: MNMA_FLAJ1
Sequence: MKRVVVGLSGGVDSSVAAYLLQQQGYEVIGLFMKNWHDDSVTISNECPWLEDSNDALLVAEKLGIPFQTVDLSEEYKEKIVDYMFNEYEKGRTPNPDVLCNREIKFDVFMKIALSLGADYVATGHYCQKSEIEVDGKTVYQLIAGNDVNKDQSYFLCQLSQEQLSKALFPIGALTKPEVREIAAEMELVTAEKKDSQGLCFIGKVRLPEFLQQKLQPKEGTIVQIDKNDPIYNVEKQAGLSLEEELKIESQKLNYRPEMGKVMGKHQGAHYFTVGQRKGLNVGGTTDPLFVIATDVDTNTIYTGLTSNHPGLFKKALFVGNSEVHWVREDLKLKEGEQMEVMARIRYRQPLQKATLHQFANGMYVHFDEPQSAITEGQFVAWYLENELVGSGVIS
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_SHIDS
Sequence: MAEITASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAKKAGNVAADGVIKTKIDGNYGIILEVNCQTDFVAKDAGFQAFADKVLDAAVAGKITDVEVLKAQFEEERVALVAKIGENINIRRVAALEGDVLGSYQHGARIGVLVAAKGADEELVKHIAMHVAASKPEFIKPEDVSAEVVEKEYQVQLDIAMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKTVGQLLKEHNAEVTGFIRFEVGEGIEKVETDFAAEVAAMSKQS
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.