PharMolix/UniProtQA huggingface dataset:
Protein: Y1756_STAAC
Sequence: MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLISGFNVNSFGDVDLTIKQLRNIKSEDEISKIRKAAELADKCIEIGVSYLKEGVTECEVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGDRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPSKEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISEKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGYEVLTHYEK
What are the official names of this protein?
Uncharacterized peptidase SACOL1756.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: CHO2_PICGU
Sequence: MAVALQQQSKTNMGPKGITFSGNTFTVPETHDMVKTLFDPTVRKSYFELVILALLASNGLVFWLVKTNSTRIEIFIGLYLFWRLSYNFGIGYLLHQQSNYHKLVNWANKLNIFDEKNHSIASRLIKSEISAQMGPKYKISKYPVDFNTWLVFRKVVDLILMSDFTTFIGVVVTCAMDNDLQFLNTSQQEPWIVYSRLIVGAGLILFNLWVKVDAHNIIKDYAWYWGDFFFRQINNEDLIFDGVFEMFPHPMYSVGYAGYYGFALIAKSYRVLVVAVFGHFLQMIFLHYIENPHIDKLYGPSGNEADYQKITKIKDLKNFDNLKPLVGLYNFSWLRAADLLTLIMVTTYSVIIPAFASSIVGTAQFRGAKINIAHCMFALTVAIKVFESLSINIFLVLQSYYKLFTKRYLANDIPIEKSLSNWAIIYNGLISWTYASFVGLNFFHYITGMEYSKFYFYDWVYLRSFLGALLILTQVWINSSIIDSIGYFGWFYGDFFLPTSPQRSHLTKAGVYRYLNNPEQLFGVCGVMGLTLIAPSLENFVCCLLWVSNNFFRINFVEKVHMIKVYGEKEVFQDSGVTKTFKKQLIPDVISRRLSSNDEAPNFGRHRSTSHLVTGITDTLESFIKELRQSNAKLSRQNLLELSQNLYFDNSDYQITIDNLQKSDDRMPKYTTIGTPIEITWKCPENHSDKDWIGLYKVVQTTYSRSKTLISSSGRWTWVESTRGSYVFTGSKLFWEEGIYEFRFHLDGKHEVAYISEPFEIKAPKIEVPDTLSASKEFAEQLKLSVFDPVTDIKIPSIESPICDTVEKSHHLLETYRRLAKLISTSTGITISSNFLFNAGTEHELSVHQLSKKLINIKKVLEDLSPAAIDEKKRQ
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RF1_THEFY
Sequence: MKLDDLLGEYYELEQQLADPAVHADQAQARTLAKRYSQLTPIVATYRELNRVESDIETAQELAAEDPSFADEAKQLAAQREELVQRLRTLLIPRDPNDDKDVILEVKAGEGGEESALFASDLVRMYLRYAERQGWKTEIISATHSDLGGYKDITIAIKNRGTVEPGQGVWHRLKFEGGVHRVQRVPVTESQGRIHTSAVGVLVLPEAEEIEVEINESDLRIDVYRSSGPGGQSVNTTDSAVRITHLPTGIVVSCQNEKSQLQNKEQALRVLRARLLAEAQAAAEAEAAAERRSQVRTVDRSERVRTYNFPENRISDHRVGYKAYNLDQVLDGELDGVIQALVDADTKERLEAAQQ
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATRX_VSIVA
Sequence: MSSLKKILGLKGKGKKSKKLGIAPPPYEEDTSMEYAPSAPIDKSYFGVDEMDTYDPNQLRYEKFFFTVKMTVRSNRPFRTYSDVAAAVSHWDHMYIGMAGKRPFYKILAFLGSSNLKATPAVLADQGQPEYHTHCEGRAYLPHRMGKTPPMLNVPEHFRRPFNIGLYKGTIELTMTIYDDESLEAAPMIWDHFNSSKFSDFREKALMFGLIVEKKASGAWVLDSISHFK
What is the function of this protein?
Inhibits mRNA nuclear export through direct interaction with host RAE1-NUP98 complex, thereby preventing interferon signaling and establishment of antiviral state in infected cells (PubMed:15629720, PubMed:33849972).  Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell (PubMed:15629720).  Inhibits host transcription, possibly through interaction with host DNA repair factor IIH/TFIIH GTF2H5 subunit (PubMed:28888655).
What are the official names of this protein?
Matrix protein, M protein.
What is the protein family that this protein belongs to?
Belongs to the vesiculoviruses matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein. Host nucleus membrane; Peripheral membrane protein. Host nucleus. Host cytoplasm.
Protein: MZM1_SCLS1
Sequence: MALEAYRHLLRATRIAFNGDIAILTSARNQARSTFLTNRSLTPESPESIAAIAHAEDVAKFLRHNVVQGQKAEGDEKYKLNIHEHTERGDNDTIKMPSGKNVTIDGKTCKD
What is the function of this protein?
Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex.  Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.  Modulates the mitochondrial matrix zinc pool (By similarity).
What are the official names of this protein?
Mitochondrial zinc maintenance protein 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family. MZM1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: MIAA_BORHD
Sequence: MKRNKIVFIFGPTAVGKSELLLNFPKGVAEIINVDSVQVYKEFDIASCKPSIELRAHVKHHLVDFLEPIEEYNLGIFYKEACEIIENLRVQKKLPVFVGGSAFYFKHLKYGLPSTPPVSSEIRLHINSLFTTRGKNYLLEELKRVDFERYESISKNDIYRIKRSLEVYYQTGIPISQFLKRGQMLANVLAIGLRRPMEEMRSRIISRVKNMIDCGLLEEIKSLLGKGYNETTPAFKGIGYREFLLWKSRPYSMLNDIINLIVKNSFLYVKRQMTFFDKIPNVLWFHPDDDLKDILDLIFV
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: ATPF_PSEAE
Sequence: MNINATLIGQSVAFFIFVLFCMKFVWPPVIAALQERQKKIADGLDAANRAARDLELAHEKAGQQLREAKAQAAEIVEQAKKRANQIVDEARDQARTEGERLKAQAQAEIEQELNSVKDALRAQVGALAVTGAEKILGASIDANAHEQLVSKLAAEI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL24_CROS5
Sequence: MSKKKSPQRYKMHVKTGDTIQVISGRDKGKVGEVLKTIPTTSEVVVKGVNVKTKHVKPQQEGESGQIATFEAPIHSSNVMLYSTKEQVASRISYTFTEEGRKVRMLKKTGEIIDS
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: SDHB_YEAST
Sequence: MLNVLLRRKAFCLVTKKGMATATTAAATHTPRLKTFKVYRWNPDEPSAKPHLQSYQVDLNDCGPMVLDALLKIKDEQDSTLTFRRSCREGICGSCAMNIGGRNTLACICKIDQNESKQLKIYPLPHMFIVKDLVPDLTNFYQQYKSIQPYLQRSSFPKDGTEVLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEQYLGPAVLMQAYRWLIDSRDQATKTRKAMLNNSMSLYRCHTIMNCTRTCPKGLNPGLAIAEIKKSLAFA
What is the function of this protein?
Subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).  SDH1 and SDH2 form the catalytic dimer.  Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4.
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Iron-sulfur subunit of complex II, Ip.
What is the protein family that this protein belongs to?
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: PHNC_MYCS2
Sequence: MNPVAGDDVVVIARDVTKRFGDTLALDHVSLDVHRSELLVLLGLSGSGKSTLLRCLNGLHPVTSGTVDVGGTRVDQASGAQLRALRRRVGFVFQHFNLVGRLSCLENVLIGGLGRLRLPRYGALTYPRHMRAEALAHLDRVGLADYADRRADTLSGGQQQRVAIARTLMQKPALLLADEPVASLDPENAGVVMDLLFRVCIEEKLTVVCTLHQVDLALGWAHRLVGLQGGRKVLDRPAVGMTRDDVMAVYQRVEPAVTPARRV
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate-import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonate/phosphate importer (TC 3.A.1.9.2) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TM269_MOUSE
Sequence: MLGTGDPNLHSSCILSRKKGRQGHHIMKHEQIGSQMTEFSWKDIINALALANMILGLFSIFCSFSRKSYCASWMLLISFLLDIAIGTMTKHLNIPHKLGLELNDFAIFTTFGLASALLLGVDGPLNGFLAIIYVLTTSFRMCFYSTGGATSGYKGLPCPYASCVLASTCLLTKGNTFILCCMASLMILFMIDQSCYPHDEILDSDNWKKIVYIGGVILLFFSPFPLTAFYCLTWSLSYIFSPETLWGRGVRIKP
What are the official names of this protein?
Transmembrane protein 269.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS6_SOLUE
Sequence: MTRIYEELFIVKPDASDEEVDAFVETLRTQLTAAGATVDKIDKWGKRRLAYRVDKYREGTYVLFQFTSEPTGVKELERRLRVSDIVLKFLTVRIDETLKRLDKRKKDRDKRAAKRAANAPASPAPAQPSLAQQMTEAPAAVPGGPMPGLPKEG
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PANB_ALKCK
Sequence: MKTTKTFKQMKRDGEPIAMLTAYDAPSARLAERAGVDMILVGDSLGMVVLGYDSTVPVSVDDMVLHTKAVKRGAPNTFVVTDMPFLTYHSSFSETAGHVRRLLQEAGADAVKLEGGTDIASTVQRLTAAGVPVVGHIGLTPQSVGVLGGYRVQGKAQEEGEQLLADAQALEQAGAFAIVVECVPKQLGALLAKEINVPIIGIGAGAETDGQVLVYHDVIGYESERVAKFVKQYTAVSPIIEEGLASYVTDVKQRAFPEEAHTYTTNDTGWLAVYGGDKK
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOC3_CANLF
Sequence: MQPRVLLVAALLALLASARALEEEDPSLLGLMQGYMQHATKTAQDTLTSVQESQVAQRARGWMTDSFSSLKDYCSTFKGKFTGFWDSASEAKPTPASDAF
What is the function of this protein?
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma.  Plays a multifaceted role in triglyceride homeostasis.  Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs).  Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.  Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
What are the official names of this protein?
Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PGSA_YERPP
Sequence: MQLNIPTWLTLFRVVLIPFFVLAFYLPFVWAPMVCAIIFVFAAATDWFDGFLARRWKQTTRFGAFLDPVADKVMVAVALVLVAEHYHSWWITLPAATMIAREIIISSLREWMAEIGKRSSVAVSWVGKVKTMAQMGSLVGLLWRPDHNVELASFVLLYIAAVLTFWSMFQYLNAAWSDLLEP
What is the function of this protein?
This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
What are the official names of this protein?
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, Phosphatidylglycerophosphate synthase, PGP synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MDH_YERPA
Sequence: MKVAVLGAAGGIGQALALLLKTQLPSGSDLSLYDIAPVTPGVAVDLSHIPTAVNIKGFSGEDATPALQGADIVLISAGVARKPGMDRSDLFNVNAGIVRNLVEQIARTCPNALIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGITTLDTIRSNTFVAELKGKQPQDIEVPVIGGHSGVTILPLLSQIPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGESNVVECSYVEGDGKYARFFAQPILLGKNGVAERKDIGKLSAFEQQALENMLDVLHKDIELGEKFVNQ
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: RS13_LIMRD
Sequence: MARIAGVDLPRDKRIVIGLTYIFGIGDSTAKKILENAGVSEDIRVRDLTPDQEEKIRAQVDQIQVEGDLRREVSMNIKRLQEIGSYRGMRHRRGLPVRGQHTKNNARTRKGKAVAIANKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: Y482_NITOC
Sequence: MFGWAVTFLIIALIAALFGFTGLAGVATHIAWILFVVGLILFVVFLLLGRRGRPPL
What are the official names of this protein?
UPF0391 membrane protein Noc_0482.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEG16_HUMAN
Sequence: MSFLTVPYKLPVSLSVGSCVIIKGTLIDSSINEPQLQVDFYTEMNEDSEIAFHLRVHLGRRVVMNSREFGIWMLEENLHYVPFEDGKPFDLRIYVCHNEYEVKVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSVLVNNGRR
What is the function of this protein?
Binds lactose with high affinity.  Strong inducer of T-cell apoptosis.
What are the official names of this protein?
Galectin-16.
Protein: TSAD_CLOBL
Sequence: MKESINILAIESSCDETSAAVVVNGREVLSNIIASQISTHEKFGGVVPEVASRKHIEVISAVVQEALDEANFTLDDIDAIGVTYGPGLVGALLVGLQYAKGLAFATGKPLIGVNHIEGHISANFIEYKDLKPPFMCLVVSGGHTFIVYMKDYGEFEVLGETRDDAAGEAFDKVARAIGLGYPGGPKIDKISKEGNEEAIKFPRANFHNDTLDFSFSGIKSAVLNYLNKKEMKGEEINKADVAASFQKSVVDVLVDNTIKACMSKKVDKIAVAGGVASNSCLRETLVRECKKKGIEVLIPPFILCTDNAAMIGSAAYFEYIKGRRTSLDINAVPNLKLGER
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT1B3_CAVPO
Sequence: MTKSEKKSLNESLAQWKLFLYNPTTREFLGRTAKSWGLILLFYLVFYGFLAALFTFTMWAMLQTLNDEIPKYRDQIPSPGLMVFPKPVTALEYTFSVSDPSSYEGYIKDLKKFLKSYSLDEQKNLNKCTDGVLFEQTGPVYAACQFPDSLLEACSGTDDPDFGYSQGQPCVLVKMNRIIGLKPEGSPRIDCISKDENTAMVSTYPNQGVIDLKYFPYYGKKLHVGYLQPLVAVQVSFGSNSTKKEVTVECKIEGSKNLRNEDDRDKFLGRVAFKITARA
What is the function of this protein?
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.  The exact function of the beta-3 subunit is not known (By similarity).
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit beta-3, Sodium/potassium-dependent ATPase subunit beta-3, ATPB-3.
What is the protein family that this protein belongs to?
Belongs to the X(+)/potassium ATPases subunit beta family.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein: FEN_PYRCJ
Sequence: MGVTELGKLIGKEARREIKLESLAGKCVALDAYNALYQFLASIRQPDGTPLMDRAGRITSHLSGLFYRTINLLEAGVKPVYVFDGKPPEFKLLEIEQRKKAKEKALEEVEKAIREGRREDVAKYAKRAIFLTSEMVEDAKKLLTYMGIPWVQAPSEGEAQAAHMAKRGHCWAVGSQDYDSLLFGSPRLVRNLAVSPKRKVGEEVVELSPELIELDAVLKSLKLKGREQLIDLAILLGTDYNPEGVPGVGPQKALKLIWEFGSLEKLLQTVLKGVQFPVDPLKIREFFLNPPVTDQYSTELSTPDERKIVELLVEEHDFSQERVAKALERLAKARGKVKTTSLDAFF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: ERGI3_MACFA
Sequence: MEALGKLKQFDAYPKTLEDFRVKTCGGATVTIVSGLLMLLLFLSELQYYLTTEVHPELYVDKSRGDKLKINIDVLFPHMPCAYLSIDAMDVAGEQQLDVEHNLFKQRLDKDGTPVSSEAERHELGKVEVTVFGPDSLDPDRCESCYGAEAEDIKCCNTCEDVREAYRRRGAFKNPDTIEQCRREGFSQKMQEQKNEGCQVYGFLEVNKVAGNFHFAPGKSFQQSHVHVHDLQSFGLDNINMTHYIQHLSFGEDYPGIVNPLDHTNVTAPQASMMFQYFVKVVPTVYMKVDGEVLRTNQFSVTRHEKVANGLLGDQGLPGVFVLYELSPMMVKLTEKHRSFTHFLTGVCAIIGGMFTVAGLIDSLIYHSARAIQKKIDLGKTT
What is the function of this protein?
Possible role in transport between endoplasmic reticulum and Golgi.  Positively regulates trafficking of the secretory proteins alpha1-antitrypsin/SERPINA1 and HP/haptoglobin (By similarity).
What are the official names of this protein?
Endoplasmic reticulum-Golgi intermediate compartment protein 3.
What is the protein family that this protein belongs to?
Belongs to the ERGIC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.
Protein: CNRY_CUPMC
Sequence: MADVEEWLTHARKVTQEASIGVDVTSIQECISAEPAQRVLVARRDAWRAICCAAFAALVAFAAINRVATIMLEKPAPTWVATPSAASPFGLLIGK
What is the function of this protein?
CnrH alone is able to activate cnr expression, and both CnrY and CrnX are needed for nickel induction of CnrH (PubMed:10671463).  In the absence of wild-type CnrY (due either to a frameshift, PubMed:10671463 or absence of the transcript, PubMed:10671464), nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor (PubMed:10671463) or an anti-sigma factor (PubMed:10671464).
What are the official names of this protein?
Nickel and cobalt resistance protein CnrY.
What is the protein family that this protein belongs to?
To A.xylosoxydans NccY.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: XHLB_BACSU
Sequence: MNTFDKGTVIRTVLLLIALINQTMLMLGKSPLDIQEEQVNQLADALYSAGSIAFTIGTTLAAWFKNNYVTEKGKKQRDLLRDNNLTK
What is the function of this protein?
Involved in cell lysis upon induction of PbsX.
What are the official names of this protein?
Holin.
What is the protein family that this protein belongs to?
Belongs to the SPP1 holin family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MUTL_BRUMB
Sequence: MTIRHLSETIINQIAAGEVIERPASVIKELVENAIDAGATRIEVVTAGGGKTLLRVTDNGSGIPADELALAVSRHCTSKLTDDVHDIRALGFRGEALPSIGSVSKLTLKSRPQDADSGFEVCVTGGHLDGPRPTALNRGTIVEVRDLFYATPARLKFMKTDRAEATAITDVVKRIGIAFPHIRFSLAGTDRTPFEMPATGTGAEATLERIGQVLGREFGENALAIDAERDGVRLAGFVGIPSFNRGNALHQFAYVNGRPVRDKQIFGALRGAYSDVIARDRHPVAVLFLTLDPALVDVNVHPAKADVRFRDPGLVRGLIVGAIKQALAQSGIRPATSGAEAMLQAFRAEGFGAQQSAPRPANSYSPASWRTAPPAPRSEWSPQTAQTAHRPLDLQAAPALRENGQAVLGDVAVPASDARASVAEAPVELMQKPLGAARAQIHENYIVAQTEDSLVIVDQHAAHERLVYEALKNALHARPIAGQMLLIPEIVDLPEEDAQRLAGHAETLARFGLGVEQFGPGAIAVRETPAMLGEMNVQQLIRDLADEIAEHDTADGLKAMLHHVAATMACHGSVRSGRRLKPEEMNALLRDMEATPGSGTCNHGRPTYIELKLTDIERLFGRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: CMOA_HISS2
Sequence: MNKDCIFAAPIEKLGDFTFDENVAEVFPDMIQRSVPGYSNIITAIGMFAERFVTANSLVYDLGCSRGAATLSARRHITQPNVKIIGVDNSLPMVERCRQHINAYQSDIPVEILCDDIRNIKIENASMVILNFTLQFVPQQDRQLLLEKIYQGLNPNGGLVLSEKFRFENKKMDDLLIDLHHQFKRANGYSELEVSQKRTALENVMRTDSIETHKERLKSAGFSQIELWFQCFNFGSMVAIK
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: URIC_EMENI
Sequence: MSTVAAARYGKDNVRVYKVHKDPKTGVQTVTEMTVCVLLEGEIDTSYTKADNSVIVATDSIKNTIFILAKQNPVTPPELFGSILGTHFINKYKHIHVAHTNIITHRWTRLNIDGKPHSHSFVRDSEETRNVQVDVTEGVGIDIKSSINKLTVLKSTGSQFWGFVRDEYTTLPEVWDRILSTDVEATWAWKRFSGLDEVRGNVPKFDETWEAARNITLKTFAEEESASVQATMYKMGEQILAYQPLLETVEYSLPNKHYFEIDLSWHKGLKNTGKDAEVFVPQTNPNGLIKCTVGRKSKAKL
What is the function of this protein?
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
What are the official names of this protein?
Uricase, Urate oxidase.
What is the protein family that this protein belongs to?
Belongs to the uricase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: ATPI_LEPVR
Sequence: MNVLSCSINTLIKEGLYEISGVEVGQHFYWQIGGFQVHAQVLITSWVVIAILLGSAVLAIRNPQTIPTDGQNFFEFVLEFIRDVSQTQIGEEYGPWVPFIGTLFLFIFVSNWSGALLPWKIIQLPQGELAAPTNDINTTVALALLTSVAYFYAGLSKKGLGYFSKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.