PharMolix/UniProtQA huggingface dataset:
Protein: GCSP_BRUC2
Sequence: MTEFLPFVARHIGPRHEDERAMLAALGLPSMETLITQAVPASIRLNRALNLPAALSEADALAELGTIMGRNVVKKSFIGAGYHGVHTPPVIQRNLFENPAWYTAYTPYQSEISQGRLELLFHFQTLVAELTGLPVACASLLDEATAVAEAIGVACRHHRDKRSRILLAGELHPQTVDVVNTRAEPLGWEIATGSDVDDNTAAIVVPWPDTRGVYGDFAKVIADAKAKGALVIAVADPLALTIMEAPARWGADMAVGSMQRYGVPMGFGGPHAAYLAVSEALTRIIPGRIVGQSVDAHGRAAYRLALQTREQHIRRDKATSNICTAQALLANMAAAFAIWHGPAGLQAIATRVAALAARFAAALKAAGVEIAGESLFDTVTAKVPGKAAAIAAEADKGGRLIRIIDADTVGVTFDETSTEEDLTALASLFGAKPVGGDTVLVPGKERGEGFLTQEVFHSHRSETEMMRFLRRLADKDLALDRAMIPLGSCTMKLNAAAEMMPVSWNTVANLHPFAPAEQVQGYAKMTSDLEAWLCEITGFAGVSLQPNAGSQGEYAGLMAIRHYHQAWGQGHRNICLIPSSAHGTNPASASMAGMSVVVVNCRPDGDIDIDDLKAKAEKHRDNLAAFMITYPSTYGVFEEGIKAFCEIVHDNGGQVYFDGANLNALVGLARPADIGADVCHMNLHKTFCIPHGGGGPGVGPIGVAKHLVPYLPGHVEAGSEHAVAAAQFGSASILVITWMYIRMMGGAGLKKATEAAILNANYIAHRLKGVYPILYTGAHDRVAHECIVDTRVLKDSAGITVEDVAKRLIDYGFHAPSMSWPVAGTLMIEPTESEPKLEIDRLCDAMIAIAGEAKKVADGVWPADDNPLANAPHTASDTLATEWKHPYTREEAVFPGGAFDPTAKYWPPVSRVDNVGGDRNLICSCPPVAAYG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: MURI_PARDP
Sequence: MAVGVFDSGLGGLTVLSAIAARMPDLPLVYLGDNAHTPYGVRDADDIFDLTCAGVERLWAEGCDLVILACNTASAAALKRMQETWLPKDKRVLGVFVPMIEALTERRWGDNSPPREVAVKHVALFATPATVASRAFQRELAFRAIGVDVEAQPCGGVVDAIEMGDEILAEALVTSHVEALLRRMPHPEAAILGCTHYPLVQAAFQKALGPQVTVYSQPNLVAESLEDYLGRHPEMLGAGNVSRFLTTGDPERVSGKATQFLRHPIRFESA
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: RAB4_DICDI
Sequence: MGKPLYLVKFIIIGSQSVGKSCLLFRFIDNKFKSQSTHTIGVDFSSRVVDIQGKNVKLQIWDTAGQERFRSVVISYYRGSAGVALVYDVTNRESYNHITNWLSDVKSLASPDVTIILVGNKADLTEQREVTFLEASRIAQENGLLFMETSALTGEGVEEMFLKCTRTIMTKIDSGEVNLEHLGVQISSDSGNVTKKPGDSSNCSC
What is the function of this protein?
Protein transport.  Probably involved in vesicular traffic (By similarity).
What are the official names of this protein?
Ras-related protein Rab-4.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: LYS1_NEUCR
Sequence: MAPTVLHLRSETKHLEHRSALTPTTTAELIKAGYIVNVERSPERIFDDEEFEKAGATLVPEHSWVDAPKEHIIVGLKELEEKDFPLKHVHVQFAHCYKQQAGWENVLARFPRGGGTLLDLEFLVDEHGRRVAAFGFHAGFAGAALALEVWAWQLNHSEPFPGVESYPNEDALIADVKKAVKEGVEAAGRLPRVIVIGARGRCGSGAVSALKKAGIPDENILDWDMAETAKGGPFKEITDSDIFVNCIYLTSKIPNFVNMESLQVPDRQLRVVCDVSADTTSPFTPVPIYTVATTFDKPTVPVDGLTSGPPLSVISIDHLPSLLPREASEAFSHDLLPSLLTLNDWQNSPVWARAKQLFDEKVATLPESALQK
What is the function of this protein?
Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.
What are the official names of this protein?
Saccharopine dehydrogenase [NAD(+), L-lysine-forming], SDH, Lysine--2-oxoglutarate reductase.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
Protein: DRIP1_ARATH
Sequence: MMIKVKKETMRACLSCSICDNILRDATTISECLHTFCRKCIYEKITEDEIETCPVCNIDLGSTPLEKLRPDHNLQDLRAKIFALKRRKVKAPGIVSLPGKRKERSISSLVVSTPMVSAQAGTTRRRTKAPTRKELRNGSLAERTVKKEESSGDELLESTSSPDTLNKFTQNKRQSKKSCKESISNKENKDGDEPWDSKMDWKPLNFLVEVANGTKPLKSSASQGSGSKSEHANVSRNQFQGSKTKTKNKKRKCKREDDKSNNGDPTTSETVTPKRMRTTQRKRSATTLGDSRNLPQPDESSAKQERRNGPVWFSLVASNDQEGGTSLPQIPANFLRIRDGNTTVSFIQKYLMRKLDLESENEIEIKCMGEAVIPTLTLYNLVDLWLQKSSNHQRFAALVGSSAKDFTMVLVYARKLPECNM
What is the function of this protein?
E3 ubiquitin-protein ligase that acts as a negative regulator of the response to water stress.  Mediates ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator DREB2A.  Functionally redundant with DRIP2.
What are the official names of this protein?
E3 ubiquitin protein ligase DRIP1, DREB2A-interacting protein 1, RING-type E3 ubiquitin transferase DRIP1.
What are the subcellular locations of this protein?
Nucleus.
Protein: BBX24_ARATH
Sequence: MKIQCDVCEKAPATVICCADEAALCPQCDIEIHAANKLASKHQRLHLNSLSTKFPRCDICQEKAAFIFCVEDRALLCRDCDESIHVANSRSANHQRFLATGIKVALTSTICSKEIEKNQPEPSNNQQKANQIPAKSTSQQQQQPSSATPLPWAVDDFFHFSDIESTDKKGQLDLGAGELDWFSDMGFFGDQINDKALPAAEVPELSVSHLGHVHSYKPMKSNVSHKKPRFETRYDDDDEEHFIVPDLG
What is the function of this protein?
Acts as negative regulator of seedling photomorphogenesis and light-regulated inhibition of hypocotyl elongation (PubMed:17605755, PubMed:18540109, PubMed:21685177).  BBX24/STO and BBX25/STH function as transcriptional corepressors of HY5 activity, leading to the down-regulation of BBX22 expression.  BBX24/STO acts additively with BBX25/STH during de-etiolation and the hypocotyl shade avoidance response (PubMed:23624715).  Functions as negative regulator of photomorphogenic UV-B responses by interacting with both COP1 and HY5 (PubMed:22410790).  May act as a transcription factor in the salt-stress response (PubMed:12909688).
What are the official names of this protein?
B-box zinc finger protein 24, Salt tolerance protein.
Protein: CLE4_ARATH
Sequence: MASFKLWVCLILLLLEFSVHQCRPLVAEESPSDSGNIRKIMRELLKRSEELKVRSKDGQTVLGTLDSKRLSPGGPDPRHH
What is the function of this protein?
Extracellular signal peptide that regulates cell fate.
What are the official names of this protein?
CLAVATA3/ESR (CLE)-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the CLV3/ESR signal peptide family.
What are the subcellular locations of this protein?
[CLE4p]: Secreted, extracellular space.
Protein: STS1_PHANO
Sequence: MNAIHGSFTPPHLLNNRHSPTRNIYPSSAMTGRKRKADDDGSSDDRMSASPSISSAELPRQQPRHMKRMRTNLSGRPLPLPRLLETLSADEMRNLLQSICQRHPDIGNEVVSTAPRPSIQSTLEVLSKYESAFQSAFPFGGRASSDYAYNRVRQQLIELLESLKDFTPHYLPPNEQQSATSLAFLDGATEIIHRLPNWDTYQHNRHKEEAYEEMAKAWAIVFREAAKKAGGIQLQYGGWDQKIAKHNEHSGGKMQEAVNELRGGLGWMGADAPAPAASGPEDAMSIRQQLLSGNYGMGSSASIGAW
What is the function of this protein?
Involved in ubiquitin-mediated protein degradation.  Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.  Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
What are the official names of this protein?
Tethering factor for nuclear proteasome STS1.
What is the protein family that this protein belongs to?
Belongs to the cut8/STS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PLSX_YERPS
Sequence: MACLTLALDAMGGDFGPCVTVPASLQALASNPQLKLLLVGNPDTITPLLANADSLLLERLQVIPAEHVIASDAKPSQAIRASRGTSMRVALELVKNGEAAACVSAGNTGALMGLAKMMIKPLEGIARPALMTVIPNQRRSKTVVLDLGANVECDSTMLVQFAVMGSVMAEEVVGIVEPRVALLNIGEEENKGLDNIREAAAVLKNTPAINYIGYLEGNDLLTGKTDVMVCDGFVGNVTLKTMEGVIRMFLSLLKPSGEGSKQSWWLKLIGRWLQKRVAKRFGHLNPDQYNGACLLGLRGIVIKSHGAANQRAFAVAIEQAVQAVQRQVPERIAARLEAVLPKSD
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: SYH_PARPJ
Sequence: MTEQKKKLEKLSGVKGMNDILPQEAGLWEFFETTVKSMLRSYGYQNIRTPIVEHTQLFKRGIGEVTDIVEKEMYSFTDALNGENLTMRPENTAAVVRAAIEHNMLYDGPKRLWYIGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDDLGLMGIKLEINSLGLAEERAAHRVELIAHLEKHMDVLDEEAKRRLYTNPLRVLDTKNPAMQEVAQNAPKLIDFLGEESRAHFEGLQRILKANNIPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGIERILELLKEEQLVPEDEGCDVYVVHQGDAAREQAFIIAERLRDTGLDVILHCSADGQTASFKSQMKRADASGAAFAVVLGEDEIANGTVGVKPLRDTNANGGKNEQQNVPAEDLTEFLINAMVATAEDGDD
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_SODGM
Sequence: MEYQLLKTDGQARRGRLVFDRGVVETPAFMPVGTYGTVKGMTPEEVKETGAQILLGNTFHLWLRPGQAVMKLHGDLHDFMQWHGPILTDSGGFQVFSLGDIRKITEEGVYFRNPINGDTIFLSPEKSMEIQYDLGSDIVMIFDECTSYPSDWDYAKQSMEMSLRWAARSRQRFDELGNHNALFGIIQGSVYEDLRDVSVKRLVEIGFDGYAVGGLAVGEPKADMHRILAHLCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNARYKDDVAPLDAECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRQAIDEGKLEHFVGEFYRRTGKPAPPLVVELHNNEGI
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: TAPFS_BPMU
Sequence: MDEMNLGPEAQELHDSIVAEIQSGVLKLKDGLPFGTGDETEMQYDVTLRELTAGDMIDAQAAAEKLVMSKEGPVLVSSPSRMGLEMLRRQIASVGCIKGPLSMALIRKLSVDDFQRLSLATEMYDMAVAASLTQERGGEWLRCRNDIEKAATAIGVILKSGPEWALSLPLSRFFRHCQQAKTLSQYHR
What is the function of this protein?
Required for tail assembly (Probable).  Together with gp41, may act as a chaperone promoting the assembly of the tape measure protein (TMP) and the tail tube protein (TTP) into a functional tail shaft (Potential).
What are the official names of this protein?
Probable tail assembly protein FS-gp41.
What is the protein family that this protein belongs to?
Belongs to the mulikevirus tail assembly protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: WHIA_STAAM
Sequence: MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: RL9_MYCA9
Sequence: MKLILTTEVEHLGTAGDAVEVKDGYGRNYLLPRGLAIVATRGAERQANDIRRAREAKEIRGVEHANEIKQAIEGLGAVKLTVKTAGEGKLFGSVTAADVVGAIKAAGGPNLDKRTVTLPKAHIKQIGSYVLDVHLHAGVATKVTVDVVAEG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: NRDR_YERPN
Sequence: MHCPFCAAVDTKVIDSRLVSDGSQVRRRRQCLDCNERFTTFEVAELVLPRVIKSDEVREPFNEEKLRRGMLKALEKRPVSSDDVETAISHIKSQLRATGEREVPTKMVGNLVMEALKRLDKVAYIRFASVYRSFEDVREFGEEIARLQD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: ESA1_GIBZE
Sequence: MAGGTPGGEPTVGSGEPRLKSLATPETIKTGCIAWVEKEGQPRRAEILSIKTTKSGKQFYCNFDNFNKRLDEWVPVIRLDFTREVEWPNPEKEKPKDPKAKKAPTVQSKKTQPSKKSQKRPSKREQSTTSEANTPHPWTDFVENQNRQKSASIGPDGDSQARASVDGGETPGGGDEMEVDERETEVKREPAEFSREVEIEKLRTSGSMTQNPTEVSRIRNISKVQFGRFDLYPWYFSPYPEIFSQEDVIFICEFCLSYYGDLKAFTRHRKKCTLQHPPGNELYRNEEISFFEIDGRRQRTWCRNLCLLSKMFLDHKTLYYDVDPFLFYVMTVRTEKGCHMVGYFSKEKESADGYNVACILTMPQYQRKGYGRLLIQFSYELSRIEGKLGSPEKPLSDLGLLSYRQYWSENILEFLMGYNERDEKVTIEAISTALAMTTQDVEHTLQALRMQVYHKSDHKIVIPEKLIEQREKTKLKRKRTVDPTKIQWKPPVFTASSRTWGW
What is the function of this protein?
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A. Z (By similarity).  Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity).  The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation.  The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity).  Recruitment to promoters depends on H3K4me.  Also acetylates non-histone proteins (By similarity).  In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
What are the official names of this protein?
Histone acetyltransferase ESA1, Protein 2-hydroxyisobutyryltransferase ESA1, Protein acetyltransferase ESA1, Protein crotonyltransferase ESA1.
What is the protein family that this protein belongs to?
Belongs to the MYST (SAS/MOZ) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Following DNA damage, localizes to sites of DNA damage, such as double stand breaks (DSBs).
Protein: LDH_CLOBH
Sequence: MIKKRNTTKISVIGAGSVGATTAYALMLSGVATEIVLVDVNKSKTEGEAMDLSHGADFVKPVNILSGDYKDTEGSDIVVITAGAAQKVGETRLQLINKNINIFKSIIPQVVKYNKDAILLVVSNPVDVLSYVTYKLSGFPKERVIGSGTVLDTSRLKHEIGKRYKIDPRNVNTYIMGEHGDSEIATWSVTNIQNIKIDEYANKENLEYNDNFRKEVYENVKNAAYEVINRKGATFYAIALAVTRIVKAILGDEKTILPVSTLVENYYGIKDVYLGMPCIVGGSGIEKALSIDLNKTEASKLVKSAETLKNTLNNASCL
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APC15_DANRE
Sequence: MSALFPSLFPRVTESLWFNLDRPCVDEAELNQQEQQHQTWLQSIVEKDNNLMPIGRPIFETFDEEEEEDDEDEEDSEEDSEDDEDMQDMDDMNIYNEFPDDGEINEVDMEGADQDQDQWMI
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
What are the official names of this protein?
Anaphase-promoting complex subunit 15, APC15.
What is the protein family that this protein belongs to?
Belongs to the APC15 family.
Protein: ATPE_BAUCH
Sequence: MTIKTYHLYVVSAEKQIFSGLVEKIQVTGIEGDLGIFPRHTPLLTQIKPGLIYLVTEDGKTEYIYISGGILEVQLNIVTVLADTAIRGEDLDEKRAINSKLQAQENIKNLNYDMSYTQASVELAKALAKLRVIKLIKKAI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YIDD_MYCTO
Sequence: MSLSRQSCGRVVRVTGRASARGLIFVIQVYRHMLSPLRPASCRFVPTCSQYAVDALTEYGLLRGSWLTMIRLAKCGPWHRGGWDPIPEGLTTGRSCQTDVDGANDDWNPASKRGERESFV
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SQUS_ECOLI
Sequence: MKWFNTLSHNRWLEQETDRIFDFGKNSVVPTGFGWLGNKGQIKEEMGTHLWITARMLHVYSVAAAMGRPGAYSLVDHGIKAMNGALRDKKYGGWYACVNDEGVVDASKQGYQHFFALLGAASAVTTGHPEARKLLDYTIEIIEKYFWSEEEQMCLESWDEAFSKTEEYRGGNANMHAVEAFLIVYDVTHDKKWLDRAIRVASVIIHDVARNNHYRVNEHFDTQWNPLPDYNKDNPAHRFRAFGGTPGHWIEWGRLMLHIHAALEARCEQPPAWLLEDAKGLFNATVRDAWAPDGADGIVYTVDWEGKPVVRERVRWPIVEAMGTAYALYTVTGDRQYETWYQTWWEYCIKYLMDYENGSWWQELDADNKVTTKVWDGKQDIYHLLHCLVIPRIPLAPGMAPAVAAGLLDINAK
What is the function of this protein?
Catalyzes the isomerization of sulfoquinovose (SQ) to 6-deoxy-6-sulfo-D-fructose (SF).  In vitro, can also catalyze the interconversion of mannose, fructose and glucose, or lyxose and xylulose, but has extremely low activity with glucose.
What are the official names of this protein?
Sulfoquinovose isomerase, SQ isomerase.
What is the protein family that this protein belongs to?
Belongs to the N-acylglucosamine 2-epimerase family.
Protein: BSC3_ALTBR
Sequence: MSQSTLVIIGAGGIGEAIARRVGPGKEVLLGDWSNALLQEATQRMKRDGFRVTSQHVNISSHDSVIQFAEKAQSLGQVMHVVISAGLSPVSSTRETILAVNLAGTGFCIAEFGKLIGHGGTCVVISSLAGYTLAQDVPHGVIQHLARTSPSDVLGLPLLRETVLDQWSAYGVSKRVNYVQVQDASLSWARRGARINSISPGAIQTPMLSLESQASKEEVVHDLAQNVPCKRVGDSGEVAHVAAFLLGSESSFVTGTDILVDGGALAYLSRDTSS
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of the diterpene glucoside brassicicene C (PubMed:19097780).  In the first step of the brassicicene C biosynthesis, the bifunctionnal diterpene synthase bsc8 that possesses both prenyl transferase and terpene cyclase activity, converts isopentenyl diphosphate and dimethylallyl diphosphate into geranylgeranyl diphosphate (GGDP) that is further converted into fusicocca-2,10(14)-diene, the first precursor for brassicicene C (PubMed:19097780).  Fusicocca-2,10(14)-diene is then substrate of cytochrome P450 monooxygenase bsc1 for hydroxylation at the C-8 position (PubMed:19700326).  Oxidation at C-16 position to aldehyde is then catalyzed by the cytochrome P450 monooyxygenase bsc7, yielding fusicocca-2,10(14)-diene-8-beta,16-diol (PubMed:19700326).  Follows the isomerization of the double bond and reduction of aldehyde to alcohol catalyzed by the short-chain dehydrogenase/reductase bsc3 to yield the diol compound fusicocca-1,10(14)-diene-8 beta,16-diol (Probable).  The next step is the oxidation at the C-3 position of fusicocca-2,10(14)-diene-8-beta,16-diol catalyzed by the alpha-ketoglutarate dependent dioxygenase bsc9, to produce a triol compound (PubMed:21299202).  Methylation of the hydroxy group at position 16 is performed by the methyltransferase bsc6 (PubMed:19097780).  16-O-methylation is followed by oxidation at the C-13 position to ketone and an alkyl shift of the methyl group leads to brassicicene C (Probable).  Although the probable acetyltransferase bsc4 is included in the gene cluster, no acetylation reactions are necessary for brassicicene C biosynthesis.  However, the fact that brassicicene E, which is a structurally related compound having an acetoxy group at position 12, was previously isolated from another strain of A. brassicicola suggests that the ATCC 96836 strain might also produce a small amount of brassicicene E (Probable).
What are the official names of this protein?
Short-chain dehydrogenase/reductase bsc3, Brassicicene C biosynthetic gene cluster protein 3.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: GRDA_ALKMQ
Sequence: MSLFDGKKVIIIGDRDGIPGPAMEECLKGTGAEVVYSSTECFVUTAAGAMDLENQKRVMDLTEKHNAENVVVILGAAEAEAAGLAAETVTNGDPTFAGPLAGVQLGLRVYHAVEPQFKDAVNAEVYEDQIGMMEMVLEVDAIIEEMSNIRNEFGKFKD
What is the function of this protein?
In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate.  Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine.  By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state.  Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.
What are the official names of this protein?
Glycine/sarcosine/betaine reductase complex component A, Selenoprotein PA, Thioredoxin reductase complex selenoprotein A.
What is the protein family that this protein belongs to?
Belongs to the GrdA family.
Protein: MUKB_KLEPN
Sequence: MIERGKFRSLTLVNWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLRAGVCYSVLDVINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPTSILPTQLLTETLNDRQARVVSLNELKDKLEAMEGVQFKQFNSITEYHSLMFDLGVVARRLRSASDRSKYYRLIEASLYGGISSTITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRIHLDKALEYRRDLFTSRSQLAAEQYKHVDMARELQEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAVDRQEENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQALQRWSAKALCHLPDLTPESADEWLETFQAKEQEATEKMLSLEQKMSVANRAHSQFEQAYQLVAAINGPWRANEAWDVAREFVRDGVNQRHQAEQAQGVRSRLNELEQRLREQQDAERQLAEFCKRQGKRYDIDDLETLHQELEARIASLADSVSNAQEQRMALRQELEQLQSRTQTLMRRAPVWLAAQNSLNQLCEQSGEQFASGQEVTEYLQQLLEREREAIVERDEVGRRKRAIDEEIERLSQPGGSEDPRLNALAERFGGVLLSEIYDDVSLDDAPYFSALYGPSRHAIVVPDLSRVAEQLEGLEDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADIQWRYSRFPALPLFGRAARENRIETLHAERESLSERFGTLSFDVQKTQRLHQAFSRFIEQHLAVTFEDDPEEEIRKLKQARGELERTVSAHESDNQQNRVQYEQAKEGVTALNRILPRLNLLADDTLADRVDEIQERLDETQEARFIQQYGNELAKLEPIFRCCRANPEQFEQLKEDYAYAQQTQRDARQQAFALAEVVQRRAHFSYSDSAEMLSGNSDLNEKLRQRLEQAESERSRARDAMRAHAAQLSQYNQVLASLKSSYDTKKELLNDLYKELQDIGVRADAGKKRARARRHELHMQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYCEMREQVVTAKAGWCAVMRLVKDNGVERRLHRRELAYLSADELRSMSDKALGALRLAVADNEHLRDVLRISEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTNREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQSVSFGQVNSVRLNVNVRETHSMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDESRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLEMQLIIAAPENISPEKGTTYKLVRKVFNNHEHVHVVGLRGFDAPLPEALPGTADAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.