PharMolix/UniProtQA huggingface dataset:
Protein: HEM3_XANC5
Sequence: MTTLRIATRKSPLALWQSEHVAAALRQHHPGLEVVLVPMSTRGDEMLDRSLAAIGGKGLFLKELELAMLRGEADCAVHSLKDVPMELDAPFVLPAILERGDPADALVSNLYASLQALPLGARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNGGYDAIVLACAGLQRLGLEARISARLDAPEWLPAPAQGAVAVECRGDDARIYSLLAVLDAGRTRACVEAERAMNRALHGSCHVPVAAFARWEGQGLFLQGMVGSASDGRLIHADAHGSAEDTEALGRRVAQGLFDKGAAQLLAEL
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: PYRH_LEGPH
Sequence: MMNESQPKLKYKRILLKFSGEALMGKSQFGIDPSVLDSLARDIAELIHMGVEVGLVLGGGNLFRGKALSQAGVGRVTGDHMGMLATVMNALALRDALERIDLPARIMSAIPMLGVVDPYHRRKAITHLRNGQVVIFAAGTGNPFFTTDTAACLRAIEIGADIVLKATKVDGVYSADPLKNSDAKRYDYLTYKEVLTKGLEVMDSTAICLCQDQGMPLQVFDMAAPKALKRIVTGERVGTIVGANHDQ
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y764_XANAC
Sequence: MPAARQQRGAAVEAAARALLEQAGLRLVVGNANYRGGELDLVMHDGPSLVFVEVRYRRDDRFGGGAASVDWRKRRKLVLAAQLFLGAHPALAALPCRFDVVDASGEPPVLHWIRDAFRADDC
What are the official names of this protein?
UPF0102 protein XAC0764.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: PSBL_PROMS
Sequence: MQVNENPNKVPVELNRTSLYLGLLSVFVLGILFSSYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: BRN3_CHICK
Sequence: MMSMNSKQAFSMHPILHEPKYPHLHTSSEAIRRACLPAPQIQGNIFAGFDETLLRGAEALAAVDIVSQKTHPFKPDATYHTMSSVSCTPTSSSVHLHHPSVLTTHHPHHHHHQPAQGLEGELLDHLNSALPLGGVPGPDVGSTPSHPHSHMSAINHMAHHSQPMNMSHPHGLASHAVISGPETETDPRELESFAERFKQRRIKLGVTQADVGSALANLKIPGVGCLSQSTICRFESLTLSHNNMVALKPILEAWLEEAERAQREKMTKPEIYTGGDKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY
What is the function of this protein?
May play a role in specifying terminally differentiated neuronal phenotypes.
What are the official names of this protein?
Brain-specific homeobox/POU domain protein 3, Brain-3, Brn-3.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLMN_SYNS3
Sequence: MISALLGRSKSELEEWAVAQGQPAFRGRQLHDWLYAKGVRDLQGITVLPKAWRASLQNEGVSVGRLHEQERRVSADATTKLLLGTEDGETLETVGIPTDQRLTVCVSSQVGCPMACRFCATGKGGLQRSLAGHEIVAQVLSIREVMERRPSHVVFMGMGEPLLNIEAVLESIRCLNDDLGIGQRRITVSTVGVPHTLPRLADLALKQLGRAQFTLAVSLHAPNQALREELIPTAKTYPYDALLDDCRYYLNKTGRRVSFEYILLGGVNDHPHHASELADRVGGFQSHVNLIAYNPIEEEEFQRPTTQRIEGFRRVLERRGVAVSLRASRGLDQDAACGQLRRNRRS
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_RHOP2
Sequence: MPTINQLIARPRVVQKSRKKVPALQQSPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHILRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: HISZ_RALSO
Sequence: MPNWLLPESIADVLPSEARKIEELRRRMLDLFRTYGYELVMPPMLEYIESLLSGTGHDLDLKTFKLVDQLSGRTIGLRADITPQVARIDAHLLNRAGVTRLCYAGSVLHTRPSGFHVTREPLQIGAEIYGHAGLEADLEIQDLMLAALSAAGLADVRLDLCHVGVLAALLAQAPVAPDVQDELFAALASKDAPALHALTAGLPAAQRDAINLLPSLYGGVDVLARARAQLPQLPAIGRALDDLATLAAHAGGAAVNIDLADLRGYHYHSGVMFAAYVAGVPNAVARGGRYDKVGEAFGRARPATGFSLDLREVAGISPVQARAAAIHAPWSGDAKLREAIAGLRATGEIVIQSLPGHPEDLEEFAYDRQLAEEGGRWVVKPRKASA
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENC_SHIFL
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLREGEREGWGEISPLPGFSQENWEEAQSVLLAWVNNWLAGDCELPQMPSVAFGVSCALAELTDTLPQAANYRAAPLCNGDPDDLILKLADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNPDYRHRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEEGVRAVVIKPTLTGSLEKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQVRRWPGSPLPLVDADVQEQLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: PUR7_METCA
Sequence: MTAPETLFESSLSSLRLKARGKVRDIYEAGDDLMLIVTTDRLSAFDVILPDPIPGKGRVLTRVSRFWFERLKDRVPNHLSGTPLEAVLPDPAEREQVEGRAMVVKRLRPLPVEAVVRGYLIGSGWKDYQRSGAVCGIGLPSGLRLAERLPDALFTPSTKAEMGSHDENIGFDQVVGLIGRELAERMREVALGLYREAAAYALDRGIIIADTKFEFGVDEAGVLHWIDEALTPDSSRFWPADGYRPGISPPSFDKQFVRDYLETLEWDKKPPAPHLPPDILARTAEKYREAERRLTGE
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: AKTP2_DROMO
Sequence: MCLETTLTKNKTLALINQGYQVLAEYEMIEQKKLRGIYAIPSYSSLLLWFGVIFIHSGMYSESAFRFSILLPDNFPDENCLPTVIFQKDIFHPHICPISHSLDLSPVFKDWHKDQHHIWHILKYIQAIFADPEGSVCNTHNGEPIPLTDVNNMEAMRLLANNRVDFALRAKASIVWSWKHMFDKPPINDPHYIIFERYRPEKHQAMMKRIKSSSWYSLPTSTSPPSTCVARIESARQLLAEEEAQTRGFHSLEMVE
What are the official names of this protein?
Protein crossbronx-like.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
Protein: AROC_NITEC
Sequence: MSGNTIGKLFCVTSFGESHGPAIGCIVDGCPPGLVLSAMDIQLELDRRKPGTSRHVTQRHEGDRVEILSGVFDNITTGTPIALLIRNEDQRSKDYSKIMDVFRPGHADYTYWQKYGIRDYRGGGRSSARETAVRVAAGAIAKKWLHERYGIVIRGYMAQLGPIAIPFKNWEVINQNPFFVADDDYVPKLEAFMDALRKSGDSAGARINVIAEGVPVGWGEPVYDRLDADIAYAMMSINAAKGVEIGAGFNSVTQKGTEHSDEITPEGFLSNNAGGILGGISSSQPITVSVAIKPTSSIRLGRRSIDKAGNPVIVETHGRHDPCVGIRATPIVEAMLAIVLMDHALRHRGQNEDVVCTTPKVPGNIINPTNPVTTQPDVRRAEDPEPDENS
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: HSCB_ECOLI
Sequence: MDYFTLFGLPARYQLDTQALSLRFQDLQRQYHPDKFASGSQAEQLAAVQQSATINQAWQTLRHPLMRAEYLLSLHGFDLASEQHTVRDTAFLMEQLELREELDEIEQAKDEARLESFIKRVKKMFDTRHQLMVEQLDNETWDAAADTVRKLRFLDKLRSSAEQLEEKLLDF
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: PGR_ARATH
Sequence: METSPQFRLIFAVIISSLIAFRSYKRKSLDLSGGIAGFLVMTIHFTAGFRYGALLLVFFLTSSKLTKVGEDKKRRVDVEFKEGGQRNWVQVLCNSGIASVLVVIACTLTGWKDKCLDSKQSEIVTALIGGIIGHYACCNGDTWSSELGVLSDAQPRLITTFKPVKKGTNGGVTKAGLLAALAAGTTVGLTFLIFGLFTASCASDVALKQLLVIPLSALAGLCGSLIDSILGATIQFSGFCSVRNKVVGKPGPTVKKISGVDILDNNGVNFVSILLTSFLTSIASVYIF
What is the function of this protein?
Involved in the glucose-triggered developmental leaf growth process.
What are the official names of this protein?
Protein PGR, AtPGR, Plasma membrane glucose-responsive regulator, Transmembrane protein 19-like protein, VTE6-related protein, VTE6R.
What is the protein family that this protein belongs to?
Belongs to the TMEM19 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MUTS_CHLPD
Sequence: MSSPPREHSPMMRQYLDVKERYPDYLLLFRVGDFYETFFDDAKEVSSALNIVLTRRSNGSSSEVPMAGFPHHASEGYIARLVKKGYKVAVCDQVEDPSEAKGIVRREITDIVTPGITYSDKILDDRHNNYLCALALLKEGRRVVAGAAFIDVTTAEFKIAELLPEEVADFVRSLHPAELLIARKEKERFEPVRKEFPPDMVVTELDDWMFGEDQASAVLARQFKTHSLKGFGIHGNSAGKVAAGVILQYLEETRQNRLHYITRIGTLQNTDYMTLDLQTRRNLEIISSMQDGTINGSLLQVIDRTANPMGARLIRRWLQSPLKRLEDIALRLDAVEEFKDFSPLRREVHGHLSEINDLERVLSRIATFRSIPREMRQFGSALSKIPLLKEALLQTTTARLQALGRSLVEMPELVALIEKAVDPEAGASMRDGGYIRAGYHQELDELRTIASTAKDRLLEIQQEERARTSISSLKVQFNKVFGYYIEISKSNLDKVPDYYEKKQTLVNAERFTIPALKEYEAKILNAEEKSIVLEQRLFHDLSLLIAEQAALVQTNAAVIAEIDCLASFAAVAEEYGYCKPEVAGHDRLLVTGGRHPVLERMMSTDDPYVSNDLLFDRKQRLLIITGPNMAGKSSYLRQAGLIVLLAQAGSFVPAQKAEIGLVDRIFTRVGASDNLASGESTFLVEMNEAASILNNATSKSLLLLDEIGRGTSTSDGMSIAWSMSEFIHDSIGARTLFATHYHELAELETRLQGVVNYNATVIETAEKVIFLRKIVRGASDNSYGIEVARMAGMPQEVIVRAKEILAGMEKREIDVSGIKQPSIESMQISLFEEADSRLRTAIENLDLDRLTPLDALIELKKLQDLALKGCGR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: YQEW_BACSU
Sequence: MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHPLKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAIKMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGADVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIGTCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAHFSLLFNVVTALLFLPLTNLFYRLIHLLIPAK
What are the official names of this protein?
Uncharacterized protein YqeW.
What is the protein family that this protein belongs to?
To E.coli YjbB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THIG_RHOPA
Sequence: MVKFYDREFGSRLLIGSALYPSPAIMQDSIRESGAEIVTVSLRRETAGGKAGDQFWSLIRELGVTVLPNTAGCRGVRDAVTTAKLARELFATSWIKLEVIADNDTLQPDVVGLVEAAQILIKDGFEVFPYCTEDLSVAMRLVDAGCRVVMPWAAPIGSARGITNRDALKLLRDRLPDITLVVDAGLGAPSHAAEAMELGYDAVLLNTAIAKAEDPVAMARGFKLAIEAGRTGFEAGLMGARDFASPSTPVIGTPFWHAVS
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_HALH5
Sequence: MLYPSIDSLMDKLDSKYTLVTVSAKRARELKEDDQRGPLVGKPKSFKPVGVALEEIVEDHLQYERKEQ
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: ILVC_BACP2
Sequence: MVKVYYNGDIQENVLNGQKVAIIGYGSQGHAHALNLKESGVDVIVGVRKGGSYTKAQEDGHQVFTVKEAAAQADVLMVLLPDEQQKKVYDEEIKDQLEAGNSLVFAHGFNVHFHQIVPPSDVDVYLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVSGQAKDKALAYAKAIGGARAGVLETTFKEETETDLFGEQAVLCGGLTSLVKAGFETLTEAGYQPELAYFECLHELKLIVDLMYEEGLEGMRYSISDTAQWGDFVSGPRVVDANVKESMKAVLTDIQNGTFAKEWIVENQVNRPRFNAINANENEHQIEVVGRKLREMMPFVKQGKKKEAVSVGAEN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RL14_MYCS5
Sequence: MIFELSRANVADNSGAKQVGVIRVLGGSKKKVAEIGDVVICSVKKALPSGDVKAGQVLKAVVVRTKRNTYRSNGSYIRFDDNAVVILKDDGTPVGTRVFGPVAREIREKYPKIVSLALEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: PYRE_PHOPR
Sequence: MKAYQRQFIEFALEKGVLKFGEFTLKSGRVSPYFFNAGLFNTGRDLARLGRFYAEALVDAGIDYDVLFGPAYKGIPIATTTAVALADHHDIDMPYCFNRKEVKTHGEGGSLVGSDLEGRIMLVDDVITAGTAIRESMEIIKANGADLAGVLVAIDRQEKGKGELSAIQEVERDFGCAVISIVSLGDVVTYLSEQDGMDAHLAAVKSYRAEYGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: DER_LEVBA
Sequence: MAYPVVAIVGRPNVGKSTLFNRIAGERISIVEDTPGVTRDRIYSRAEWLGTEFRMIDTGGIDMGDEPFLTQITQQAEIAIDEADVIVFIVSAPEGITDADEKVAKILYRADKPVILAVNKADNPEVRESIYDFYSLGFGDPYPVSGVHGLGLGDLLDAVVKEFPEKDGAPKDDSIRFSLIGRPNVGKSSLVNAMLGEERVIVSNIAGTTRDAIDTKFVADDTKFTMVDTAGIRKRGKVYENTERYSVMRAMRAIDDSDVVLVVLNAEEGIREQDKRVAGYAHEAGRGIIILVNKWDTLKKDNHTLTDFQNLIRIEFQYLSYAPIIFVSAKTGQRLEQLPEMIKRVADNHNKRVQSATLNDVVMDAIALNPTPSDNGKRLRVYYATQVAIAPPTFVVFVNDPKMMHFSYERFLENQIREHFDFEGTPIHLIERARK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: RL2_HALSA
Sequence: MGRRIQGQRRGRGTSTFRAPSHRYKAELSHKRTEDTDVLAGEVIDVEHDPARSAPVARVAFEDDDQRLVLASEGVGVGDTIEIGISATIEEGNTLPLAEIPEGVPVCNVESHPGDGGKFARAGGVNADLVTHERDATIVELPSGETKRLSPDCRATIGVVAGGGRTEKPFVKAGNKHHKMKARGTKWPRVRGVAMNAVDHPFGGGGRQHPGRPKSVSRDAAPGRKVGDIASKRTGRGGNE
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: LEPA_ACIF5
Sequence: MTEQQHIRNFSIIAHVDHGKSTLADQFIRLCGALTEREMSSQVLDTMDIERERGITIKAQSVRLQFRAADGQEYQFNLIDTPGHVDFSYEVSRSLAACEGALLVVDASQGVEAQSVANCYTALEHNLEILPVLNKIDLPAADPERVRREIEAIVGLPADDAVEASAKEGTGIREILERVVERIPPPQGDPEAALQALIIDSWFDNYLGTVVLVRVMNGSIRPGQRILTMVGQKPYVVEKVGVFTPKSLMVPALETGAVGFVIAGVRTIEGARVGDTLTEQDRPASAPLPGFREVQPQVFTGLYPVDSADYESFREALQKLRLNDAALQFEPETSQALGFGFRCGFLGLLHMEIVQERLEREYQLELISTAPTVIYEVLTTDGQVLKISNPAELPAAQKIADIREPVITANILVPETYLGPVIALCEERRGRQKNMQFTGGQVMLRYELPHNEVVLDFFDRLKSVSRGYASMDYEFARFESGPLVKMDILINGEKLDALSWIVHRDVSERRGRELVVRLRDLIPRQMFEVAIQAAIGARVIARESVKALRKNVLAKCYGGDISRKRKLLEKQKEGKKRMKQVGHVEIPQEAFLAVLKSDKR
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BOLA_ECOLI
Sequence: MMIRERIEEKLRAAFQPVFLEVVDESYRHNVPAGSESHFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTTVHALALHTYTIKEWEGLQDTVFASPPCRGAGSIA
What is the function of this protein?
Transcriptional regulator that plays an important role in general stress response.  Has many effects on cell morphology, cell growth and cell division.  Acts by regulating the transcription of many genes, including dacA (PBP-5), dacC (PBP-6), ampC and mreB.  Probably involved in the coordination of genes that adapt the cell physiology in order to enhance cell adaptation and survival under stress conditions.  Essential for normal cell morphology in stationary phase and under conditions of starvation (PubMed:10361282, PubMed:12354237, PubMed:19111750, PubMed:21464593, PubMed:25691594).  Also regulates a complex network of genes encoding proteins related to biofilm development, and negatively modulates flagellar biosynthesis and swimming capacity.  Could be a motile/adhesive transcriptional switch, specifically involved in the transition between the planktonic and the attachment stage of biofilm formation (PubMed:25691594).  Overexpression produces round cell shape, impairs cell growth rate and induces biofilm development (PubMed:305364, PubMed:15345459, PubMed:21464593).
What are the official names of this protein?
DNA-binding transcriptional regulator BolA.
What is the protein family that this protein belongs to?
Belongs to the BolA/IbaG family.
Protein: HIS4_FLAJ1
Sequence: MRIIPAIDIIEGKCVRLSKGDYDTKIIYNENPLEVAKSFEAYGIEYLHLVDLDGAKSSKIVNYKILEQIATQTSLKIDFGGGLKSDDDLRIAFESGANQITGGSIAVKNRTIFEKWISEYGSEKIILGADAKDEKIAVSGWLEESNEDLVPFIQDYQNKGIQYVICTDIAKDGMLQGPSFDLYSKILAEAKGVKLIASGGISTFDELPKLAELGCEGTIIGKAIYEGRITLKQLENYIIG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAL11_YEASC
Sequence: MKNIISLVSKKKAASKNEDKNISESSRDIVNQQEVFNTEDFEEGKKDSAFELDHLEFTTNSAQLGDSDEDNENVINEMNATDDANEANSEEKSMTLKQALLKYPKAALWSILVSTTLVMEGYDTALLSALYALPVFQRKFGTLNGEGSYEITSQWQIGLNMCVLCGEMIGLQITTYMVEFMGNRYTMITALGLLTAYIFILYYCKSLAMIAVGQILSAIPWGCFQSLAVTYASEVCPLALRYYMTSYSNICWLFGQIFASGIMKNSQENLGNSDLGYKLPFALQWIWPAPLMIGIFFAPESPWWLVRKDRVAEARKSLSRILSGKGAEKDIQVDLTLKQIELTIEKERLLASKSGSFFNCFKGVNGRRTRLACLTWVAQNSSGAVLLGYSTYFFERAGMATDKAFTFSLIQYCLGLAGTLCSWVISGRVGRWTILTYGLAFQMVCLFIIGGMGFGSGSSASNGAGGLLLALSFFYNAGIGAVVYCIVAEIPSAELRTKTIVLARICYNLMAVINAILTPYMLNVSDWNWGAKTGLYWGGFTAVTLAWVIIDLPETTGRTFSEINELFNQGVPARKFASTVVDPFGKGKTQHDSLADESISQSSSIKQRELNAADKC
What is the function of this protein?
High-affinity uptake of alpha-glucosides such as maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose, melezitose and glucose (PubMed:15128531, PubMed:10368160).  Acts with the concomitant transport of protons into the cell (symport system) (By similarity).  Provides an alternative and minor mechanism for growth on trehalose carbon source by transporting trehalose into the cytoplasm for conversion to glucose by neutral trehalase NTH1 (PubMed:15128531, PubMed:10368160).
What are the official names of this protein?
General alpha-glucoside permease, Maltose permease MAL11, Maltose transport protein MAL11.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y769_MYCTU
Sequence: MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFGGIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGVNGLTQQLARELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMCLFLLSDSASWITGQIFNVDGGQIIRS
What are the official names of this protein?
Uncharacterized oxidoreductase Rv0769.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: GNGF_STRPQ
Sequence: MKNPKMTVIGGGTGISIILKSLRNEAVDITAVVTVADDGGSSGELRNAMQLAPPGDLRNVLLAMSDMPKFYERVFQYRFNESDGALAGHPLGNLIIAGISEMQGSTYNAIQILTKFFHITGKIYPSSEQALTLHAVFKDGHEVAGESSIAKYQGMIDHVYVTNTYNDQKPQASRKVVEAILESDMIVLGPGSLFTSILPNLVIPEIKEALRQTKAEVVYICNIMTQYGETEQFSDADHVAVLNQHLGRDLIDTVLVNVAKVPQAYMNSNKFDEYLVQVDHDFAGLCRAAKRVISSYFLRLENGGAFHDGNLVVEELMNLVRIVKQ
What is the function of this protein?
Required for morphogenesis under gluconeogenic growth conditions.
What are the official names of this protein?
Putative gluconeogenesis factor.
What is the protein family that this protein belongs to?
Belongs to the gluconeogenesis factor family.
What are the subcellular locations of this protein?
Cytoplasm.