PharMolix/UniProtQA huggingface dataset:
Protein: CRCB_HAES1
Sequence: MNLFTHLFLISCGASLGAMSRHGLTLLLNPLFTFLSFGTLIANYIGCLIMGIMLAMFWHSSAFSTEYRLFFVTGFLGSLTTFSAFSAEVIENLLQHKWLEGITITSLHILGCLFFTTLGVFIWRYFQ
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KHSE_PYRAB
Sequence: MKKRIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGYDVPRDENNVAVISAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDELIIMAALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDVELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAIGENLKDIGKAMKEKFEELGIRAEFWITKTGRGAKWY
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_PORG3
Sequence: MAKELKELTPRSESYSQWYQDLVIKADLAENSAVRGCMVIKPYGYAIWEKMQRQLDDMFKETGHVNAYFPLFIPKSFLSREAEHVEGFAKECAVVTHYRLKANPDGDGVVVDPQAKLEEELIVRPTSETIIWNTYKNWIQSHRDLPILCNQWANVVRWEMRTRLFLRTAEFLWQEGHTAHATKEEAEEEARRMLEVYATFAEEYMAMPVVKGVKSANERFAGAVDTYTIEALMQDGKALQSGTSHFLGQNFAKAFNVTFADKDGNRDFVWATSWGVSTRLMGALIMSHSDDNGLVLPPKLAPYQVVIVPIYRNEEQLAQIDEKATQIIQALRAKGISVKYDNSDNKKPGWKFAEYELKGVPVRLAMGARDLENNTIEIARRDTLTKETVGLDGIEETVATLLDDIQKNIFQKALNYRKEHTITVDSYEEFKEKIEDGGFILAHWDGTSETEERIKAETKATIRCIPLNGDMTPGKCMVTGKPSPQRVLFARAY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBC_SALTI
Sequence: MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARHTARLVLEGRDTPQHILPELNEMYFVDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEGFQAFTRRVERFISRLGAFSDCQNLLIVSHQGVLSLLIARLLAMPAASLWHFRVEQGCWSTIDICEGFATLKVLNSRAVWRPE
What is the function of this protein?
Catalyzes the conversion of adenosylcobalamin 5'-phosphate to adenosylcobalamin (vitamin B12); involved in the assembly of the nucleotide loop of cobalamin.  Also catalyzes the hydrolysis of the phospho group from alpha-ribazole 5'-phosphate to form alpha-ribazole.
What are the official names of this protein?
Adenosylcobalamin/alpha-ribazole phosphatase, Adenosylcobalamin phosphatase, Alpha-ribazole-5'-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family.
Protein: SYM_BORBU
Sequence: MKKMNLVTAALPYVNNIPHLGNLVQVLSADAFARYSKMSGIETLYVCGTDEYGTATETKALIENTTPLELCNKYYEIHKSIYKWFNIEFDIFGRTTNKNHQDIVQNFFLQLEKNGYIKERETEQFYCNKDSMFLADRYVIGECPECQSMAKGDQCDNCSKLLNPTDLINPKCIICKNKPILKKTNHLYLDLPKIKTKLEKWIKNPDTSKNWNTNALKMTKAFLRDGLKERAITRDLKWGIPVPKKGFENKVFYVWFDAPIGYISITKNIIKNWESWWKNNDQVNLVQFIGKDNILFHTIIFPCIEIGSEENWTILNQLSSSEYLNYENLKFSKSEGTGIFGNDAITTGIPSDIWRFYIYYNRPEKSDFQFMWQDLMERVNTELIDNFSNLVNRVLTFQRKFFGDVIETIEIQNKFWKQITPKYNKILNLFKKTELKSALKEILKISSLGNKIFQDNEPWKRKNNSPQETKELISNLIYLIRDLSILMMPFIPETSKKIQQFFGNSYQFSTKILGTKSGIKKIEFTEILFNKLEQKKINNLKLKYSGDKNMKENEQAENLPIAKEQPENLFREKVLLRVVKINKIERNPEAKNLFILKLDDGTNKDKQIVSGLEGYYTEEELLGKHIIIVDNLKPAKFRGIKSEGMLIAAEDKNKNFKVIIVEDSIQNPIAGERIILENDQNKDLACPPKIDINKFLKANIVAENGELKINGINLILENSKNKILSKDIPNGTVC
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL2_FELCA
Sequence: MYKIQLLSCIALTLILVTNSAPASSSTKETQQQLEQLLLDLRLLLNGVNNPENPKLSRMLTFKFYVPKKATELTHLQCLVEELKPLEEVLYLAQSKNFHLNHIKELMSNINVTVLKLKGSETRFTCNYDDETATIVEFLNKWITFCQSIFSTLT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HSF2_CHICK
Sequence: MKQEPQQQQPAQQPPPAGAGVPAFLSKLWALVGEAPSNQLITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMASFVRQLNMYGFRKVVHVDSGIVKLERDGLVEFQHPYFKQGREDLLEHIKRKVSSSRPEENKISQEDLSKIISSAQKVEIKQETIESRLSALKRENESLWREVAELRAKHLKQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLLNTNGPTKSNVFQQIVKEPADNNNHVPLNRTEGLKQREQISDDIIIYDVTEDVADEENTMVDEENAPITPETNEDTTSDSSNCSRSPDIVIVEDDNEEEYAPVIQGDKSTESVAVSANDPLSPVSDSTSPLMSSAVQLNNQSTLTAEDPVSMMDSILNENGVISQNINLLGKVELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLFDLFTSSVQMNPTDHIPNTKMETKGIETTKSNAGPAASQETQVSKPKSDKQLIQYTAFPLLAFLDGNPGSTVESGSSATETPSSVDKPLEVDELLESSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPMDTDMPFLDN
What is the function of this protein?
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.  HSF2 shows constitutive DNA binding activity, even without heat shock.
What are the official names of this protein?
Heat shock factor protein 2, HSF 2, HSF 3B, HSTF 3B, Heat shock transcription factor 2, HSTF 2.
What is the protein family that this protein belongs to?
Belongs to the HSF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
Protein: CBPA1_MOUSE
Sequence: MKRLLVLSVLLAAVFGNENFVGHQVLRISATDEAQVQKVRELEELEHLKLDFWRDPARAGLPIDVRVPFPTIQSVKAFLEYHDISYEIMIEDVQSLLDEEKQQMSAFQARALSTDAFNYATYHTLDEIYEFMDLLVTEHPQLVSKIQIGSTFEGRPINVLKFSTGGTNRPAIWIDTGIHSREWVTQASGVWFAKKITKDYGQEPTLTAILDNMDIFLEIVTNPDGFVYTHKTNRMWRKTRSHTEGSLCVGVDPNRNWDAAFGMPGASSNPCSETYRGKFPNSEVEVKSIVDFVTSHGNIKAFISIHSYSQLLLYPYGYTSEPAPDKEELDQLAKSAVTALTSLHGTKFKYGSIIDTIYQASGSTIDWTYSQGIKYSFTFELRDTGLRGFLLPASQIIPTAEETWLALLTIMDHTVKHPY
What is the function of this protein?
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
What are the official names of this protein?
Carboxypeptidase A1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMD_STAA9
Sequence: MKIDYLTLFPEMFDGVLNHSIMKRAQENNKLQINTVNFRDYAINKHNQVDDYPYGGGQGMVLKPEPVFNAMEDLDVTEQTRVILMCPQGEPFSHQKAVELSKADHIVFICGHYEGYDERIRTHLVTDEISMGDYVLTGGELPAMTMTDAIVRLIPGVLGNEQSHQDDSFSDGLLEFPQYTRPREFKGLTVPDVLLSGNHANIDAWRHEQKLIRTYNKRPDLIEKYPLTNEDKQILERYKIGLKKG
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_BURM1
Sequence: MNDSVKTSLKRTLIGRVVSNKMDKTVTVLVEHRVKHPIYGKYVVRSKKYHAHDEANTYNEGDLVEIQETRPVSKTKAWAVARLVEAARVI
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: YCAD_SALPB
Sequence: MSTYTRPVMLLLCGLLLLTLAIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNHSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRIVNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLLRNAGQTPNPVAHI
What are the official names of this protein?
Uncharacterized MFS-type transporter YcaD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS1_SALG2
Sequence: MLDNTRLRIAIQKSGRLSDDSRELLARCGIKINLHTQRLIAMAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLNRRAQGEDPRYFTLRRLDFGGCRLSLATPVDEAWDGPAALDGKRIATSYPHLLKRYLDQKGVSFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMAQSKQQLIDKLLTRIQGVIQARESKYIMMHAPSERLEEVIALLPGAERPTILPLAGEQQRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNT_BAUCH
Sequence: MAEKDEVNTLRARFRGFYPVVIDVETAGFNSGTDALLEIAAITLQMDHHGWLKTHKTLHFNIEPFPGSILQPEALIFNGIDPDNPLRYAVTEREALYELFTIVHQGIKDDDCHRAILVAHNAAFDHSFLMAAANRTKIKHNPFHPFATFDTAALSGLVLGQTVLLKACLTAGIPFNTSEAHSALYDAERTAELFCELVNRWKRLGGWTKVTTSSIHSV
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.
Protein: RNB_CROS8
Sequence: MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRVIAVIHTEKEKESAEPEELIEPFLTRFVGRVQKKDDRLSIVPDHPLLKDAIPCRAERGVSHDFQNGDWAVAEMRRHPLKGDRGFYAELTQFITFGEDHFVPWWVTLARHNLEREAPDGVATEMLDENLTREDLTALDFVTIDSASTEDMDDALYVEALDGDRLQLTVAIADPTAWIAEGSKLDNIAKVRAFTNYLPGFNIPMLPRELSDDLCSLREGVQRPALVCRMIIEADGAISDDIHFFAAIIESKAKLAYDDVSDWLEEKGDWQPGSEAIAAQIRLLQQICQRRSAWRTEHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANICAARVLRDKLGFGVYNVHAGFDPASTEQLATLLQSHGMHVDANDVLTLPGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAIIKGESATRPQDEATVQMAERRRLNRMAERDVGDWLYARFLKDKAGTDSRFAAEIIDVSRGGMRVRLVDNGAVAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSVIARPVA
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFLD_ECOBW
Sequence: MAKNYYDITLALAGICQSARLVQQLAHQGHCDADALHVSLNSIIDMNPSSTLAVFGGSEANLRVGLETLLGVLNASSRQGLNAELTRYTLSLMVLERKLSSAKGALDTLGNRINGLQRQLEHFDLQSETLMSAMAAIYVDVISPLGPRIQVTGSPAVLQSPQVQAKVRATLLAGIRAAVLWHQVGGGRLQLMFSRNRLTTQAKQILAHLTPEL
What is the function of this protein?
Negative regulator of phage lambda lysogenization.  Contributes to the degradation of the phage regulatory protein CII.  Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease.
What are the official names of this protein?
High frequency lysogenization protein HflD.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HIS2_DINSH
Sequence: MSVLARLEATIAARKGADPDSSWTAKLLAKGPEKCAEKFGEEAVEAIIEAVKGDRAKLTSEAADVLYHLLVMLAARDVALAEVLAELERREGISGISEKASR
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_BRUA2
Sequence: MAKSKFERTKPHVNIGTIGHVDHGKTSLTAAITKFFGEFKAYDQIDAAPEERARGITISTAHVEYETANRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPAIVVFLNKCDQVDDAELLELVELEVRELLSKYEFPGDEIPIIKGSALAALEDSSKELGEDAIRNLMDAVDSYIPTPERPIDQPFLMPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKATTKTTVTGVEMFRKLLDQGQAGDNIGALIRGVGREDVERGQVLCKPGSVKPHTKFKAEAYILTKDEGGRHTPFFTNYRPQFYFRTTDVTGVVTLPAGTEMVMPGDNVAMDVTLIVPIAMEEKLRFAIREGGRTVGAGIVSSIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIO_BISBI
Sequence: MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: SCNA9_TITDI
Sequence: MLKFAIAVALLLFIGLELREARDGYPQSKVNYCKIYCPNTTVCQWTCKNRAGATDGDCRWSSCYCFNVAPDTVLYGDPGTKPCMA
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.  This toxin binds, in vitro, to sodium channels and inhibits the inactivation of the activated channels.  Seems not toxic to mice, crickets and sweet-water shrimps (By similarity).
What are the official names of this protein?
Toxin TdNa9, PT-alpha* NaTx7.1.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYT_HYPNA
Sequence: MINVTLPDGSKREYAEGASPLDVAESISKSLAKKALAAKVDGQMWDLVRPLEGDASVAIITDRDPEGLELIRHDAAHVLAQAVQELYPDTQVTIGPVIDDGFYYDFARKEPFSTDDFDKIEARMREIVDADYPIVREVLGKDEAIATFKSLGEEYKAQIIDDIIPPGEQITVYRQGKWFDLCRGPHLPSTGKLPKAFKLMKLAGAYWRGDHRNEMLQRMYGTAWANEKDLKDHLTRLEEAEKRDHRKLGAQLDLFHFQPEAQGSVFWHPKGFMIWRELEAYIRRQQDADGYVEVKTPQLLNSVFWEKSGHWSKFRENMFVVPDEIPSTESDAPILSGEGELMALKPMNCPAHVQIFKNAQRSYRDLPIRMAEFGCCHRNEAHGALHGLMRVRQMTQDDAHIFCREDQIADETLRFLKLFETVYGDFGLSEISYKLATRPEMRAGTDETWDRAEKALADALTAAGMTFSIAEGEGAFYGPKLEFHLTDAIGRTWQCGTFQLDYVLPERLDAEYTGSDGAKHRPVMLHRAVFGTFERFMGILIENYAGSFPLWMSPVQVVVAAITDAAGDYAEEAAAALRKAGLRVEVDKRNETINYKVREHSVQKVPVIAVVGAREAEDRKLALRRLGSNGQQIISLDEALVALADEARAPDLKRARS
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INHA_TRIVU
Sequence: MLPLLLPLQLLLLMVMKGGHGCQGPELDRELVLAKVRALVLDALGPPNASKDGGKPVAQRLTRRHAHTGGSTRRSMENEDEDLSQVILFPTTGPGCEDEPEARAAEGLFTYTFRPSLHTRSRQVTAAQLWFHTGLDKVGAEVHNDSGPMVTLLAMSSGGPMAVPILLGPAPPHWAVLHLAAPAFTLLTRPLLVLLLRCPNCPCPAQLDATPFLVAHTRARPPSVGERARRSPLPPPWPWSPAALRLLQRPSEDPAAHADCHRAALNISFQELGWDQWIVHPPSFIFHYCHGGCGLVPSPVLSPGAALTPSQPLPLGPGSRPCCAAMPSTMRPLRVRTTSDGGYSFKYEIVPNLLTQHCACI
What is the function of this protein?
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.  Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.  Inhibins appear to oppose the functions of activins.
What are the official names of this protein?
Inhibin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL4_HELPY
Sequence: MSKAIVLDSHLKEKGSVELPKRYESINSHNLYLYVKHYLSSARANTAKSKNRAEVSGGGRKPWAQKGGGRARAGSITSPVFVGGGVSHGATNNRNYNLKINKKQKRLALEYALEEKAQANKLFVVEKIAIKGVVEDNKRKHLTKEANQMFQALEQRDTLFVCMNMDEYTELAFSNLKKCLIVDVSELNAYLLAAFSSVVMEEAAFQHVVQDKTEE
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: TPIS_BACP2
Sequence: MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPYPDKVEAIVCAPALFLEKLNSLSNGTDLKIGAQNMHFEENGAFTGEISPAALKDLGIGYSVIGHSERREFFAETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNELVADQVKKALAGFTTQQVAESVIAYEPIWAIGTGKSSTAKDANDVCAHIRQTVASEYGQEAADSLRIQYGGSVKPANIKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAH_SARSX
Sequence: MAPIEILKFPISSPGDISPLKKLQDAGYDPSNILAVVGKTEGNGCVNDFSRTLASAVWEPRIPSDAVTIFSGGTEGVLSPHVTFFLRSPGDKETGLSAAVGHTRRFEPHEIGTDEQAQQVATTTSSLIEQMGVTPDQVHMVLIKCPLLTSEKLETIRALGRVPVTTDTYESMARSRYASAVGIAAAVGEIQHTRIPEAVSKAGTWSAKASCSSGAELEDCHILVLASTSAQGSRLHAVSRPMADAMDAASILALMELAKKDGGKIVQVFAKAEADPSGHVREWRHTMNTDSDIHSTRHARAAVGGLIAGLVSDAEIYVSGGAEGQGPSGGGSLCLVYETSI
What is the function of this protein?
Responsible for the hydrolysis of cyanuric acid, an intermediate formed during catabolism of s-triazine based compounds in herbicides such as atrazine and polymers such as melamine.  Catalyzes the hydrolytic opening of the s-triazine ring of cyanuric acid (2,4,6-trihydroxy-s-triazine) to yield carbon dioxide and carboxybiuret, which spontaneously decarboxylates to biuret.  Only active on cyanuric acid and N-methylisocyanuric acid.
What are the official names of this protein?
Cyanuric acid amidohydrolase, CAH, Cyanuric acid hydrolase.
What is the protein family that this protein belongs to?
Belongs to the cyclic amide hydrolase (CyAH) family.
Protein: RBSD_PSEE4
Sequence: MKKTPLLNIALSRTIAGLGHGDILVIGDAGLPVPPGVELIDLALTPGIPDFTSVLRVVLSEMQVERHVLAEEMFQAAPLGLIEVEQMHARGEIGQREVMNHADFKALTRQARAVIRTGECRPYSNIALVAGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGDC_HYPBU
Sequence: MAVQQNVKKGGREAGGDLIVGKHVYGNLYGVDEEKLWDEELLKDIVVEAARVANMNLVDIKTWKFTGFHGGVSVIALVLESHISIHTWPDYGYATVDVYTCGANSDPWKAFNYIVLKLKPRYYIVHYADRSSIPGYTESEKR
What is the function of this protein?
Specifically catalyzes the decarboxylation of L-arginine to agmatine.  Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.
What are the official names of this protein?
Arginine decarboxylase proenzyme, ADC, ArgDC, Pyruvoyl-dependent arginine decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: CYPX_USEUD
Sequence: MAHCFFDMTIGGQPAGRIIMELFPDVPKTAENFRALCTGEKGIGPSGKKMTYEGSVFHRVIPKFMLQGGDFTLGNGRGGESIYGAKFADENFIHKHTTPGLLSMANAGPGTNGSQFFITTVATPHLDGKHVVFGKVVEGMDVVRKIEATQTDRGDKPLSEVKIAKCGQL
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase, PPIase, Cyclophilin, Cyclosporin A-binding protein, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.