PharMolix/UniProtQA huggingface dataset:
Protein: TRM5_PLAVS
Sequence: MRNAVDIKTLADVKEKVKHEKRTHCLVLNKYRVNELLKNKDAKIWFLNIFRFPSVLKFREYQGCLVETGPYDGEVLRFIHSYVESLGGGEVSGQVSGQVNDQLSCQMTSHANDSQAGTPLADAPLADCRLIPLNARFNRALHELMQREGKGVLEGVDMRPEEGDERDVAAEGGGVEDVAQQGAAHQDAPPALEKLLRVIKAEGIQIRTIQLQFGYDNMNTSQVLRKVFPSESEVIHKYEMIGHIAHLNFCERFENHKKVIAEIILDKNKSIRTVINKKDSLKNVHRTFTIELLAGEENYLTMLRENDIKVKLNYELMYWNSKLKKERDRIYSLVENNSIVVDVFAGVGIFSLHLSKKNCLCFSNDINLHAYNFMNVNIKLNKRRSILTYNLDARAFVCMLLRLGIFSRDTSTLAMQLGEQNWRNVSLDFVNSAGRDVVDAGKGKKRAADCKVDCKEDCKEDCKEDCKEDCKEDCKEDCKEDCKEDCKEDCEVKDCKAGDSHQSNSHQSNPHESNPHESAPRDKKKKLAHGDANGPLGERPPGVAATHGGEEVPPEPTNNEAEQKAEDAPTNETHQVDINLGIYGDVHVLMNLPQTALDFLDVFRELLHMYSAGQKDPQGRCRRDQMRNVFIHCYFFSKPELFYEHAERNIRMQLGGIPREMKITEIRKVSPSKLMYVVEFNLKDVFSQGDQLG
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Protein: DSBB_NITMU
Sequence: MSNPMRPVRSILLAIFTGCAGLIGYALYLQLVENLLPCPLCVVQRMAYWLIGLTALAGFFHTPETTGRRIYAGLMAVFAFTGGLVALRQAWLVRYPEAFECGISPEEAFLNALPLARWWPVMFEANGDCADVTWKFASLTLPDWSAIFFMILAALSIYVLLVRENQRE
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF1A_PYRAB
Sequence: MPKKERKVEGDEVIRVPLPEGNQLFGVVEQALGAGWMDVRCEDGKIRRCRIPGKLRRRVWIRVGDLVIVQPWPVQSDKRGDIVYRYTQTQVDWLLRKGKITQEFLTGGSLLVE
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
What are the official names of this protein?
Translation initiation factor 1A, aIF-1A.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.
Protein: DNAA_STAAC
Sequence: MSEKEIWEKVLEIAQEKLSAVSYSTFLKDTELYTIKDGEAIVLSSIPFNANWLNQQYAEIIQAILFDVVGYEVKPHFITTEELANYSNNETATPKETTKPSTETTEDNHVLGREQFNAHNTFDTFVIGPGNRFPHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHHVLDNNPDAKVIYTSSEKFTNEFIKSIRDNEGEAFRERYRNIDVLLIDDIQFIQNKVQTQEEFFYTFNELHQNNKQIVISSDRPPKEIAQLEDRLRSRFEWGLIVDITPPDYETRMAILQKKIEEEKLDIPPEALNYIANQIQSNIRELEGALTRLLAYSQLLGKPITTELTAEALKDIIQAPKSKKITIQDIQKIVGQYYNVRIEDFSAKKRTKSIAYPRQIAMYLSRELTDFSLPKIGEEFGGRDHTTVIHAHEKISKDLKEDPIFKQEVENLEKEIRNV
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRI_ECOL6
Sequence: MTHDNKLQVEAIKRGTVIDHIPAQIGFKLLSLFKLTETDQRITIGLNLPSGEMGRKDLIKIENTFLSEDQVDQLALYAPQATVNRIDNYEVVGKSRPSLPERIDNVLVCPNSNCISHAEPVSSSFAVRKRANDIALKCKYCEKEFSHNVVLAN
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: ILVD_NITHX
Sequence: MPAYRSRTSTHGRNMAGARGLWRATGMKNEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNVPAVFVSGGPMESGKVNVNGKIRSVDLIDAMVAAADDSVSDADVEAIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSVLATHADRKGLFVEAGHLIVDLARRYYEQDDARVLPRAIASFKAFENAMTLDISMGGSTNTVLHLLAAAYEGEVPFTMKDIDRLSRRVPVLCKVAPSVVDVHLEDVHRAGGIMGILGELDRAGLIDSSLPTVHSTSLKDGLERWDIKRTKSDSVRSFYLAAPGGVRTQVAFSQDKRFEELDADRSSGCIRDAEHAFSKDGGLAVLYGNIARDGCIVKTAGVDDSILTFSGPARIFESQDAAVDAILTNRIQPGDVVLIRYEGPRGGPGMQEMLYPTSYLKSKGLGKQCALITDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEEGDRIVFDIPNRKVHLDVSDAELERRRAAMEAKGDKAWKPAPRKRRVTMALKAYAAHATSAALGAVRVVKD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: SFSA_MARSD
Sequence: MSEPLIFYPQGCCRAIFIRRYKRFTVEAMLDGEVVGVHTNNTGSMLGLLREGQEIYISPAQNPNRKLKWTLEAVMPFGEMIGVNTSVPNKMLQLAFEAGQLPEAGGYTAIKREAKVGNSRLDGLFTDDSGKLPKLWVECKNVTLVEDDIACFPDAQTERGRKHLVELMDLAAKGDRVALFFFVQRTDGSCFGPADFIDPEYAELFYKALDAGVKCWAYEAVLSERGIGIGRKLPLAACR
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: NUOB_BLOPB
Sequence: MKYTLTTARTDNSEDEQYPLQEKKIVTDPLEKNIQRNVFFGKLSAFLHKIVNWGRGNSLWPYNFGLSCCYVEMTTAFTAIHDVARFGSEVLRASPRQADFMVIAGTPFLKMVPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFLPVDLYIPGCPPRPEAYIQGLLLLKKSINEERRPLSWVLGDQGIYRKNMESERQRKRNTRIAETVLSSPDDELNIYSKQNGEA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VE2_HPV29
Sequence: MENLANRLDACQDKILELYERDSDKLEDQITHWYLMRVESALYYKARECGMTRIGHQVVPTLSVAKAKACSAIEMHVALQQLQQSAYGKEPWTLRDTSREMWDAVPKRCWKKRGVTVEVRYDGDETKAMCHVLWKDIIVQNLSDDQWVKVKGQVSYEGLYYVHEDVKVFYVKFHKDARVYGETGIWEVHVGGKVIHHNAFDPVSSTQEVPATGPLYASHNTTRSPTQAPLGPEEGQERKRRRLEAVGPGPQQQQQQQHQQQQQQQTPTHTPSTQACARTGGPVDSNRTRDCDSTSQNPYRHPSDPDCAPVIHLRGDPNSLKCFRYRLQNGKKGLYCKASSTWRWSCEPENQSAFVTIWYTSVTQRAEFLANVKIPPGMQAILGHMSVF
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: MUTS_CLOBM
Sequence: MGLTPMMRQYLEVKESCKDCILFFRLGDFYEMFFEDAKVASKELELVLTGRDCGLEERAPMCGIPYHAANTYIGRLVSAGYKIAICEQLEDPSASKGIVKRGIIKIITPGTYTDSSFLEENKNNYIMSFYLDDNMCSMSFADISTGEFNSTHSNFKEAVVLDEISKFAPREIVLEENIKESFIHTIKERFPNISISKIKEENFDYNIDNNLREQFNNFSENEYETIVKKSANGLLYYIFHTQKNILSNINKIDYYSIVDYLTIDVNSRRNLEITENLREKIKKGSLLWVLDKTNTAMGGRQLRRWIEQPLINKTPIENRLNAVEELLNNISLQEDLKEDLKSIYDIERIVGKVASKSVNAKELISLKCSIGKVPYIKKYLSSFKSDLFLNMEQCIDTLEDIHKLLDKALLDNPSLSVKEGNIIKEGFNEEVDSLREAKSNGKKWIASLEQKEKEETGIKSLKVSYNKVFGYFIEITKANLNLVPEGRYIRKQTLSNAERYITPELKEMEEKILGAEEKLIDIEYKLFTEIRDFIEENIDRMQKTARIISDIDCLCSLATVALENNYIKPNINAKDEILIEEGRHPVVEKVIPKGEFISNDSLIDTKENQLILITGPNMAGKSTYMRQVALITIMAQIGSFVPAKEANISICDKIFTRIGASDDLAAGKSTFMVEMWEVSNILKNATSKSLVLLDEVGRGTSTYDGLSIAWSVIEYICNNKNLRCKTLFATHYHELTKLEDNIKGVKNYSVSVSELENEIVFLRKIIRGGADQSYGIEVAKLAGLPSPVINRAKEILQHIEGDKEENSLNITPSKEYKSKDYIEVSKDTLNTKNNLESEIKHDTLSETNTATIIEDESIKEHLCSNKKQIQCKKNNEKSIKKELAVDSFQINFEHIKKDKVIEEIKNIDILNMTPMEGFNKLYDIINKTKDID
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: DEF_HELP2
Sequence: MALLEIIHYPSKILRTISKEVVSFDSKLHQQLDDMHETMIASEGIGLAAIQVGLPLRMLIINLPQEDGVQHKEDCLEIINPKWIETKGSMMYKEGCLSVPGFYEEVERFEKVKIEYQNRFAEVKILEASELLAVAIQHEIDHLNGVLFVDKLSILKRKKFEKELKELQKKQKRE
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: HIS1_STRMK
Sequence: MSATQAAPARDRLRIAIQKSGRLAEPARNLLSACGLSWRESRDKLFCYGESLPVDLLLVRDDDIPGLIADGVCDLGIVGRNELDEQAAARRQIGLPDAYQALRGLGFGQCRLMLAVPEEWQWQGPAQLAGARIATSYPAILKQWLAEQGVDAQVVELSGSVEIAPRLGTADLICDLVSSGATLRANQLTPVHNLLDSEAVLAGAVRVPDDARASLRAMLLRRLDGVVQRQDRKLLMFRASEDRVDALAQLLADAEPLVRLPADGGALRLQTMCPGPLSWQRMEELERAGAQGLMVLSVERSLA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBID_CLOPE
Sequence: MFDMYIESGGKKLRCGYTTGSCAAAAAKAATYMLFNKKDISVIEIDTPKNIKLNLEIQDIQVEKNSISCSIVKDGGDDIDATSGLEIFAKAEEVEEGFELCGGEGVGVVTKEGLFVEKGQPAINPVPREMIKKEVLSVLPKDKGVRITIFVPRGREIAKKTFNPRLGIVNGISILGTTGIVYPMSEEALKESIRIEIRQKAVNNKDLVFVFGNMGERFLRERGYKKDNIVVISNYVGFSIECALAQGIKDLTIVGHIGKLSKIAFGCFNTHSRVSDVRLEVIALELTLMGYDLELVQKVLDQKTSEGAVRLLGEDFPMLYERIGEKVLNRLDIYAYGEANFNILMYYGSKEMKLLYESKNSNLFD
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: TATA_PROA2
Sequence: MFGLGGQELLLILLIILLLFGAKKLPELAKGLGKGMKEFKKAQTEIEDEFNKAMSDPPEKKEKESPSDKG
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PSB_METKA
Sequence: MKELDQLTKGTTTVGILADKGVVLAADRRAVMGNLIAGKQVKKIFRIHDYIGVTTAGSVADAQKIVDLMRAEARLYELRHNRMISARALANMISHVLHSSLKAFRPYLVQLIVGGFNDDDPALYNLDPSGSIIEEDYTATGSGSPTAYGVLEAEYEEGMSLDDAIEVAVRAVKSALERDTGTGEGVTVVTITREEGYRELPEEEVEKLLS
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PsmB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CIKA_THEVB
Sequence: MPQPIFDRILPAFLYERIATVLLAQASRRGATVLTREEVIASTDAPFLIVVAESFALLLQAEPVPQMSTYRVAILTNPRAIARFLRKIRSQVPVNRRPLIRAVLQQLSPLNAKEQMLPADLAIALMAVLGEETTAQCQSCQPLVTAALNERQAQERLLHQVTTQIRQSLELPELLKIAVDRIREFLDVDRLLVGQFAQTEGELRGQITYESCRNSEIPSVLGIWDDCWQWSGLPSSSYQRLSQGEAIVVSDIQQFYGAVPCLQSFAAHWQIKSWLIVPIIVQDRLWGVLIAHQCDRPRQWQPQEVEFLTHLSQHLSIAIYQAQLYSELQQQKATLEQRVNERTQALREALSAMEAAHRIKNDFLATMSHELRTPLTCVIGVSATLLRWPLGPLTAKQREYLEIIHESGTHLLELINSILDLSEAELGRSQLHRSAFSIRQLCADCLEVVKPQAHRHQVNLRHQLMIPPTRDRFWGDYRRIQQILINLLSNAIKFTPAMGEVILRAWWKEDELIFQVQDTGIGIPAHLQSLLFQKFQQLDSSFGRAYTGAGLGLALTKQWVDLHHGWIDVDSTEGKGSTFTVGLPAISDPLPDPPKPKLDVPPLATTEVLVEPEGRIVLVSEDEATSTLICSILTTAGYQVIWLVDGEVERLLALTPIAVLLAEPFSYGDVQELVDQLRQRCTPEQLKIFILGSKGNYQGVDRYIPLPIHPESFLQQVTMGLTSLATSAQ
What is the function of this protein?
Also functions in a two-component CikA/RpaA output pathway from the circadian clock, negatively regulating kaiBC expression independently of labA and of sasA.  One of three clock output pathways.  Dephosphorylates phospho-RpaA, enhanced by KaiB and KaiC, has only modest kinase activity on RpaA.
What are the official names of this protein?
Circadian input-output histidine kinase CikA.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the phytochrome family.
Protein: UNCL_ARATH
Sequence: MEPSPSSPPSSPPEILDLDSIKALKILGKGATGTVFLAHDVVSTSSSSSPFAVKLVPKSSASSLRRARWEIEVLRRLSVDSNQNPFLPRLLASFESPEYFAWAVPYCSGGDLNVLLHRQNDGVFSSSVIRFYVAEIVCALEHLHTMGIAYRDLKPENILIQQSGHVTLTDFDLSRSLKKPLRPHFYQPDPELIIDRKKSRSFSRLISPTAEKNKTGLKKTRSARVNPINRRKTSFSSGERSNSFVGTDEYVSPEVIRGDGHDFAVDWWALGVLTYEMMYGETPFKGKSKKETFRNVLMKEPEFAGKPNDLTDLIRRLLVKDPNRRLGCHRGAAEIKELAFFAGVRWDLLTEVLRPPFIPLRDDGELTVGGFDIREHFEKLRTTPSSAPPSPLRSPPHVCRKNDPFIEF
What is the function of this protein?
Regulates planar ovule integument development.
What are the official names of this protein?
Serine/threonine-protein kinase UCNL, AGC serine/threonine-protein kinase subfamily 2 member 4, Protein UNICORN-LIKE.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ARGR_CHLPM
Sequence: MNKPARQLRIREIIQQEHVENQHDLLRLLKEKGVKVAQATLSRDCAELGIIRSKTHAGYRLLFAEEHSGRIIKGLVGMEVVSVAANETSVIVRTLPGRAHGVGSWLDQFHSPLILGTIAGDDTVLVIPDSVENISALISYIHKNLSTN
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUD2_METJA
Sequence: MKNISTKESFFKFKFNNRSLYCWGAFMKLRMKPEDFIVEEIIDFNKIAGDRCYLYKLTKRNIESLKAFSYIAKKFKIPLKDIGYCGLKDRHALTTQYISIPKKYGKLSLDEPNLKLELIGESKFLLLGDLEGNRFTITVRGLKKEDIPKIKENLKYLEFGAPNYFDSQRFGSVFDKKFIAKEVIKGNYEEAVKILLTKYKKSEKKLIKDLKRFIDKNWGDWDKIWEYIKENNIKSRLYVNMVKELKKSNDYKKALSYVDDRLKKIFVAAYQSYLWNECVKELLRKYVPEEDRVYYEYECGTLMFYKKMDEEVFNILKDKKFPTIAPDIEYSGEEKEIIEEILKREGLTMEELNNIGELGKFIYSERKILSIPKNLKIGEFEEDELNKGKYKITLSYELEKGSYATIIIKRAFLGVKTKKRKR
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase D 2, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D 2, tRNA-uridine isomerase D 2.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: SYP_RUBXD
Sequence: MTEAVERLTKKSEDSSRWYLELVRMAKLADYGPVRGTFAIRPYGFAIWERIQADLDARFKATGHVNAYFPLLIPESYLTKEAEHVEGFAPECAWVTVGGDDELEERLAIRPTSESIICDFYRKWIHSYRDLPVLINQWCNVLRWEMVTRPFLRTAEFLWQEGHTVHATAEEAREEALRMLNVYRDCFYEVLAIPVLTGMKSPSERFAGAVETFTCEGLMGDGRALQAATSHDLGQNFARAFDITFLDENQERVHPYQTSWGFSTRTIGALILVHGDDRGLRLPPKLAPTQAVVVPIWRGKNKGEVRREAEALHRELAEAGLRAEADLDEEHSPGWKFNEHELRGVPVRVELGPKDIEKGQAVLVRRDTGEKEFVGRGAAARRLVELMDEIQQNMLRQAEAFRDENTRRAETYEEFKEIIEEKRGFVVAPWDGTEETEQRIKEETKATIRLLPFEREEGKDLVSGRPGKTAVFARAY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_HALH5
Sequence: MLTDRQLLILQAIVDDYIRSAEPVGSRSISKREDITFSPATIRNEMADLEELGFLEKPHSSAGRIPSQKGYRYYVDHLLMPHRLTKKERHYIHELFTKRIQEVEQAIQQSAQILSSMTRYISVVLGPEMFETKLKSIHMIPLTAHSVVVIFVTDTGYVENQTMHLPHSVNPVDLEKTVNILNERLAGVSLFQLREKLNKEVADVLRFHVTNYELVLDLLEKTFEAEKSEKVFYGGKTNLLSQPEFRDVEKIKQILTILEQDDVMHQMIRSSGEQIQVRIGHENNVEAFEDLSVITASYSIGGKHMGTIGIVGPTRMEYRRTISVVEHLSKDLTKLLTDLYQQS
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: ARGB_RHIME
Sequence: MSASESEIQARLLAQALPYMQRYEHKTIVVKYGGHAMGNAELGRAFASDIALLKQSGVNPIVVHGGGPQIGAMLNRMGIESKFEGGLRVTDEKTVEIVEMVLAGSINKEIVALINQTGEWAIGLCGKDGNMVFAEKAKKTIRDPDSNIERVLDLGFVGDVVEVDRTLLDLLARSEMIPVIAPVAPGRDGHTYNINADTFAGAIAGALNATRLLFLTDVPGVLNKKGELIKQLSVAEARALIADGTISGGMIPKVETCIEAIKAGVQGVVILNGKTAHSVLLEIFTEHGAGTLIVP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AICDA_BOVIN
Sequence: MDSLLKKQRQFLYQFKNVRWAKGRHETYLCYVVKRRDSPTSFSLDFGHLRNKAGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGYPNLSLRIFTARLYFCDKERKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL
What is the function of this protein?
Single-stranded DNA-specific cytidine deaminase.  Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA.  Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.  May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
What are the official names of this protein?
Single-stranded DNA cytosine deaminase, Activation-induced cytidine deaminase, AID, Cytidine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly cytoplasmic. In the presence of MCM3AP/GANP, relocalizes to the nucleus.
Protein: ZRAR_ECO57
Sequence: MTHDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVRERVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHIIDAETPAVTASQFGMVGKSPAMQHLLSEIALVAPSEATVLIHGDSGTGKELVARAIHASSARSEKPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLDEIGDISPMMLVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGRFRQDLYYRLNVVAIEVPSLRQRREDIPLLAGHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAVERAVVLLTGEYISERELPLAIASTPIPLAQSLDIQPLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR
What is the function of this protein?
Member of the two-component regulatory system ZraS/ZraR.  When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP.  Positively autoregulates the expression of the zraSR operon (By similarity).
What are the official names of this protein?
Transcriptional regulatory protein ZraR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL2_HPV52
Sequence: MRYRRSTRHKRASATQLYQTCKASGTCPPDVIPKVEGTTIADQLLKYGSLGVFFGGLGIGTGAGSGGRAGYVPLSTRPPTSSITTSTIRPPVTVEPIGPLEPSIVSMIEETTFIESGAPAPSIPSATGFDVTTSANNTPAIINVTSIGESSVQSVSTHLNPTFTEPSIIQPPAPAEASGHVLFSSPTISTHTYEEIPMDTFVTSTDSSSVTSSTPIPGSRPTTRLGLYSRATQQVKVVDPAFMSSPQKLVTYNNPVFEGVDTDETIIFDRSQLLPAPDPDFLDIIALHRPALTSRRGTVRFSRLGNKATLRTRSGKQIGARVHYYHDISPIQPAEVQEDIELQPLLPQSVSPYTINDGLYDVYADSLQQPTFHLPSTLSTHNNTFTVPINSGIDFVYQPTMSIESGPDIPLPSLPTHTPFVPIAPTAPSTSIIVDGTDFILHPSYFLLRRRRKRFPYFFTDVRVAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: RPOA_PROA2
Sequence: MIYQMQMPERIEVDEATHSESIGQFVAQPLERGYGVTLGNAMRRVLLASLPGTAITGIKIDGVFHEFSTIDGVREDVPEIVLNLKKVRFKSTTKRSCKTSLSIEGPADFKAGDIVAQEGEFEVLNKDMHIATLNGDAKLNIDIYIGRGRGYVPAEENRGEGMPIGFIAIDSIFTPIKNVKFSVENTRVGQRTDYEKMILDVETDGSISPDDSISLAGKVINEHVSLFANFSPTEEEFAEEEYKQQDDEFENMRKLLQTRIEDLDLSVRSHNCLRLAEIDTLGDLVSRKEDELLTYKNFGKKSLTELKEQLDKCELKFGMDITKYQMKS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.