PharMolix/UniProtQA huggingface dataset:
Protein: FBID_MYCVP
Sequence: MNNSHADVGLVIAVKRLTAAKTRLAPMFSARTREDVVLAMLVDTITAAIAVPALRSVLVVTPDEDAADAARQLGALVLPDPTPQGHHDPLNNALTAAEVVARRENTNVVALQGDLPALRTVELAEAIGAARAHARSFVTDRHGTGTSALFSFGAPLDPHFGLDSAQRHRRSGAVELTGDWPGLRSDIDTPDDVLALNDLGVGPATARAIARAQ
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
Phosphoenolpyruvate guanylyltransferase, PEP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: CHED1_SYNAS
Sequence: MGDVIVSISDFRVSNNVGDILVTYALGSCIAVAIYDPKVKVGGLLHYMLPDSSLDVDKAKTTPGMFADTGIPLLFKACYSLGAQKKSMIVKVAGGASILDDTNFFRIGQKNIMMARKMFWKNNVLINGEDTGSNCNRTVRLEIKTGKVFVKSSGGPLREL
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD 1.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: OBG_SORC5
Sequence: MRFVDRCRLKVIAGDGGNGAIAFRREKYIPFGGPAGGDGGRGGDVVFVGDGGLSTLLDFTYARTLEADRGEHGMGSDCHGRAGADRVEKLPVGTQIFDAESGELLADVTEHGQRVIVARGGKGGRGNLHFKSPHDRAPRRAEPGEPGEARELRLELKVLADVGLLGFPNAGKSTFVAAVSAARPKIGDYPFTTLTPILGMVEIGGGVRAGGSSFVIADIPGLVPGASEGVGLGIQFLRHVERTRALLHLVTLDPGEGREPLADYRALRKELKKFSPEIAERPEIVVLTKADLTEVRDAYPKLKARFAKAKVKLHLISAATGEGVPELVRELAALARKREEPAEQDG
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASNA_HAEIG
Sequence: MKKTFILQQQEISFVKNTFTQNLIEQLGIIEVQGPILSQVGNGMQDNLSGIEKAVQVNVKCIPNAVFEVVHSLAKWKRHTLARFNFKEDEGLFVHMKALRPDEDSLDSTHSVYVDQWDWEKVIPEGRRNFAYLKETVNSIYRAIRLTELAVEARFDIPSILPKQITFVHSEDLVKRYPDLSSKERENAICKEYGAVFLIGIGGKLSDGKPHDGRAPDYDDWTTESENGYKGLNGDILVWNDQLGKAFELSSMGIRVDESALRLQVGLTGDEDRLKMDWHQDLLNGKLPLTIGGGIGQSRLAMLLLRKKHIGEVQSSVWPKEMLEEFSNIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_LAWIP
Sequence: MEQSELGFIEKVVSLNRVAKVVKGGRRFSFSALVVVGDGKGSVGFGLGKAQEVPEALRKATEQARKAMMKIPLIEGTLPYEILGEFGAGSVMLKPASRGTGIIAGGAVRAIMEAAGVTDVLAKAIGTNNPHNVLRATMAGLSALRSAQLVSNIRGKLLEAPRK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: ISPG_SHIB3
Sequence: MHNQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDEAEAFKLIKQRVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFAQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNNDMIDQLEARIRAKASQLDEARRIDVQQVEK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: S10A4_BOVIN
Sequence: MAYPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDETAFQKLMSNLDCNKDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK
What is the function of this protein?
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy.  Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity).  Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity).  Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity).  Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity).  In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity).
What are the official names of this protein?
Protein S100-A4, Metastasin, Placental calcium-binding protein homolog, S100 calcium-binding protein A4.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
What are the subcellular locations of this protein?
Secreted. Nucleus. Cytoplasm.
Protein: PUR7_PSE14
Sequence: MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEEAGVPTQFDKLLGDNECLVKKLDMIPVECVVRNYAAGSLVKRLGIEEGTRLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLVRMKELSIKVNEVLTKLFDDAGLLLVDFKLEFGVFHGEIVLGDEFSPDGCRLWDKDTRKKMDKDRFRQGLGDVIEAYEEVANRLGVPL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RS11_CAMJE
Sequence: MAKRKIVKKKVVKKNIAKGIVYISATFNNTMVTVTDEMGNAIAWSSAGGLGFKGSKKSTPYAAQQAVEDALNKAKEHGIKEVGIKVQGPGSGRETAVKSVGAMEGIKVTFLKDITPLAHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: E2F7_HUMAN
Sequence: MEVNCLTLKDLISPRQPRLDFAVEDGENAQKENIFVDRSRMAPKTPIKNEPIDLSKQKKFTPERNPITPVKFVDRQQAEPWTPTANLKMLISAASPDIRDREKKKGLFRPIENKDDAFTDSLQLDVVGDSAVDEFEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRNLQRLGEEQKYEEQMAYLQQKELDLIDYKFGERKKDGDPDSQEQQLLDFSEPDCPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDAPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSSDEELVDVSASVLPELKRETYGQIQVCAKQKLARHGSFNTVQASERIQRKVNSEPSSPYREEQGSGGYSLEIGSLAAVYRQKIEDNSQGKAFASKRVVPPSSSLDPVAPFPVLSVDPEYCVNPLAHPVFSVAQTDLQAFSMQNGLNGQVDVSLASAASAVESLKPALLAGQPLVYVPSASLFMLYGSLQEGPASGSGSERDDRSSEAPATVELSSAPSAQKRLCEERKPQEEDEPATKRQSREYEDGPLSLVMPKKPSDSTDLASPKTMGNRASIPLKDIHVNGQLPAAEEISGKATANSLVSSEWGNPSRNTDVEKPSKENESTKEPSLLQYLCVQSPAGLNGFNVLLSGSQTPPTVGPSSGQLPSFSVPCMVLPSPPLGPFPVLYSPAMPGPVSSTLGALPNTGPVNFSLPGLGSIAQLLVGPTAVVNPKSSTLPSADPQLQSQPSLNLSPVMSRSHSVVQQPESPVYVGHPVSVVKLHQSPVPVTPKSIQRTHRETFFKTPGSLGDPVLKRRERNQSRNTSSAQRRLEIPSGGAD
What is the function of this protein?
Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response.  Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'.  Directly represses transcription of classical E2F transcription factors such as E2F1.  Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes.  Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3).  Required for placental development by promoting polyploidization of trophoblast giant cells.  Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication.  Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.  Acts as a negative regulator of keratinocyte differentiation.
What are the official names of this protein?
Transcription factor E2F7, E2F-7.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPS_SALPC
Sequence: MGKTNDWLDFDQLVEDSVRDALKPPSMYKVILVNDDYTPMEFVIDVLQKFFSYDVERATQLMLAVHYQGKAICGVFTAEVAETKVAMVNKYARENEHPLLCTLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: TILS_VIBVY
Sequence: MDALYSHFSQVLEQQRKANTRLVVAFSGGVDSRVLLELAHRYAQEHLLPCCAVHVHHGLSHNADQWVQSCAAWCQEKNIPLTVERVQLDLTQGNSIEEEARNARYQALRAHINADDLLLTGQHADDQVETFLLALKRGSGPKGLSSMAQQMPFSQGRLIRPLLDVRRQEIERCAHAIGLNWVEDESNQDTRYDRNFLRQQILPALSERWPSFAASVQRSATLCAEQEALLDELLLPVFEQLFGEDQSLAITLLSQQSELARFKLFRMWLAKLGHPMPTRHQLSLIWQQVALSQADANPILQLSQGQVRRFNQRLYLVADNQDLSAWHAPITLNTPLALPDGLGTIELTLSRGFGQIALPEQSEALWISFNPEGLSAHPAERGHSRKLKKLFQEYQVPSWLRRRTPILMYHQQVVAVAGLFVDRQFIGQDCELFWRK
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_BORA1
Sequence: MPTISQLVRKPREVSIIKSKSPALENCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTNGYEVISYIGGEGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGSLDLQGVKDRKQARSKYGAKRPKKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: F16PA_PELPB
Sequence: MSNLITIERHILEQQKFFPDAQGELTDLLNDVAFAAKLVRREVVRAGLVDILGFTGSTNVQGEEVKKLDLFANEKIISAIGQHGRFAIMGSEENEGVIIPPKNESGNYALLFDPLDGSSNIDVNVSVGTIFSIYKLKGDDPGKASLSDCLQHGYEQVAAGYVIYGSSVVMVYTTGHGVHGFTYDPTIGEFLLSHENIITPKSGKYYSINEGSYAQFNEGTKRYLDYIKEEDPATNRPYSTRYIGSLVADFHRNLLTGGVFVYPPTTKHLKGKLRLMYEANPLAFICEQAGGRATNGRDRILDIQPLELHQRTPLYIGSVDDVILAEEFEQGIR
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_POLAQ
Sequence: MANDYFFTSESVSEGHPDKVADQISDAILDAILAQDPTARVAAETLCNTGLVVLAGEITTHANVDYIQVARNTLREIGYDNTDYGIDYKGCAVLVAYDKQSPDIAQGVDKAHDDGLDQGAGDQGLMFGYACDETSELMPMPIHLSHRLVERQSQLRRDGRLNWLRPDAKSQVTLRYVDGKPDSIDTVVLSTQHDEEISLEKLREAVIEEIIKPVLPKHLIKGAINFLVNPTGRFVIGGPQGDCGLTGRKIIVDTYGGAAPHGGGAFSGKDPSKVDRSAAYAGRYVAKNVVAAGLASKCLIQISYAIGVAKPTSVMVSTFGTGKISDEKIAQLVSENFDLRPKGIVKMLNLLRPIYRKTAAYGHFGREEPEFTWEQTDKAAALRAAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_SALDC
Sequence: MIALIQRVTRASVTVEDEVTGEIGPGLLVLLGVEKEDDEQKANRLCERVLGYRIFSDADGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPSFSGGAAPDRAQALYEYFVERCRQQAINTQTGRFAADMQVELVNDGPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMC_ACIBC
Sequence: MNKSNRIQTAELDWESIDGIEVPISKQFGDVYFSKDNGLLETRHVFLNGNDLSERLANLQDFEYFSVGETGFGTGLNILALWQLWQQVRPNNHSHLHAISVEKFPLSKADLIRALNVWDELRPLSKQLIEQYPFPLAGCHRLSFPEERFSIDLWLGDAQDIFPSMVKTKAVNAWFLDGFAPSCNPDMWEQNVLNNIVRLSDYGTTFASFSVAGILKRGLKAHGVDITRPRGFGHKREMLKAVWKAPVSEEILLEPVRDTFQFTQQRIAVIGAGIAGLSTAWAFAQRGHQVTLFERTVPLSGASGNPLALLNPKLCPIEQSHEHLMTLSWQHALNFYKNFQAFRPIQIQQMALKNAQDLLDLADQYPADIVTQQTSSLESDYPHILLTEAGAVSPHQLRDEILQHPGIELKIANITTLISFENKVQLKSGNETTLEADHVVVCCARESAALFENYPLLKPIRGQVSWVDNSFATLPLNEAYSYGGYCMQLNTSELILGASFYPNRDDQEVLLDDHVHNFELIHSVFPHYAKQLPPVEQWQGRASVRAQSPDYFPLVGKMQNESRISTFAGLGSKGFLFAPLCSEVLVAQILGEACPVPKSLLQKLDAQRFQKKVKPKKPYFKSQ
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_DICTD
Sequence: MSIGLPRGVQDILPDEIPFWHLIENIARSLFEKYNYEEIRTPIFEFTELFVKGTGETTDIVMKEMYTFQDKKGRSLTLRPEGTPGVIRAYLMNKIYTTKPIWKVYYIGPMFRYERPQSGRYRQFHQLGVEVLGRKDPYIDFEVISLAVEILKSLKLENLEIEINSLGCLKCRPAYREALKNYFYQYKDLLSPIDQERLERNPLRILDSKDEKIIPLKENAPQPLDFLCNDCKDHFDKVLRYLQEASLNFKISPKLVRGLDYYTRTVFEITTTSLGAQNAVVGGGRYDNLVETYGGPSTPGLGFALGMERLILLIKQQDKIKIEKPSLFFLAIENEKYIKKAVEISKILRINHRVEIGSPNEPLRTQLKWADKLNSDYVIFINQMIEKDILRIKNFKTGEEKEIRIENLKEL
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAPR_LISMH
Sequence: MKKYSKKDRQMKLQVAIEENPFITDEQLAEKFGVSVQTIRLDRVALSIPELRERIKHVASVTYADAVKSLPIDEVIGEIIDIQLSKSAISIFDVRSEHVFKRNKIARGHHLFAQANSLATAVIPNEIALTTQATVRFVRSVNEGERIIAKAKVRPATDNRAITIVDVKSYVGDEIVLKGKFEMYHATQK
What is the function of this protein?
Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.
What are the official names of this protein?
Transcription factor FapR, Fatty acid and phospholipid biosynthesis regulator.
What is the protein family that this protein belongs to?
Belongs to the FapR family.
Protein: OSTP_RABIT
Sequence: MRIAVICFCLLGMAYALPVKHADSGSSEEKQLYHKHPDALATWLNPDPSQKQNLLTPQNAMSSEEKDDLKQETLPSKSIESHDHMDDIDEDEDDDHVDNRDSNESDDADHPDDSHHSDESHQSDESDEVTVYPTEDAATTVFTEVVPTVETYDGRGDSVAYRLKRSKSKMFHVSNAQYPGASEEDLSSHVDSEDLDDTPRAIPVAQHLNVPSDWDSQEKDSHDVSQVDDHSVETQSHEQARQYKREANDNSVEHSHSIDSQESSKVSQESQSREFRSHEDKLAIEPKSEEDEEHRQLRVSHELDSTSSEIN
What is the function of this protein?
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
What are the official names of this protein?
Osteopontin, Bone sialoprotein 1, OC-1, Secreted phosphoprotein 1, SPP-1.
What is the protein family that this protein belongs to?
Belongs to the osteopontin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYI_MOOTA
Sequence: MDYSKTLNLPRTDFPMRANLPQREPEILKFWEENDIYGKVQEANRGKPKFILHDGPPYANGHLHLGHTLNKILKDIIIKYHSMNGYDAPYVPGWDTHGLPIEQQAIKNLGLNRHAVDVVEFRNRCRDYALKYVNIQREEFKRLGVRGDWEHPYLTLEPEYEAIQIGIFGEMAKKGYIYKGLKPVYWCTDCETALAEAEVEYGEERSPSIYVKFPVADARGLFEPRGSSIVIWTTTPWTLPANVAIALHPEFKYVLIQVGEERLLMAAELVRPVLELLGVKDYQVVATFTGSELEGVVCRNPLMDRDSVVILGEHVTLEQGTGCVHTAPGHGLEDYEVGMRYHLPVLSPLDDRGRFTEEGGQFAGLFIDEANKAVVKELEARGALLHFGFIKHQYPHCWRCKHPIIFRATEQWFASIEGFRQEALEAIKKVKWIPSWGEDRIYNMVADRSDWCISRQRTWGVPIPIFYCANCGREIINDATISHLQELFRKHGSNVWFAREAGELVPPGLKCPECGSKEFRKETDIMDVWFDSGSSHAAVLATRPELAWPADLYLEGSDQHRGWFNSSLSTAVATRGRAPYRQVLTHGFLVDEEGRKMSKSLGNGIDPADVIRQRGADVLRLWVASADYRRDVAASENIMRQITEAYRKIRNTCRFLLANLADFDPGKDQVPREEMLELDRWAMNRLQRLIARVTMAYDDYEFHVVYHTIHNFCAVDLSAVYLDIIKDRLYTWPAASKGRRSAQTVLYETINVLVRLLTPILAFTTEEIWRYLPGEDDRPISVQLAGWPQVKTEFLDDELEEKWKRILQVRDVVARALERARQEQDLGNSLNAAVHLYPDADMYQFLKPLGDELATIMIVSRVDLHQPGEEAPAGSLEAPELPGLRVYVTGAPGQKCERCWMVSETVGQDTDHPTLCRRCATVVKEMYMNG
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_ECO81
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQIAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLDGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMQMAERFKMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLGVPVVCTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLADLADLDVLSTEDLKNRRYQRLMSYGYA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_TERTT
Sequence: MHNLTIAEISRKLQAKEFSSEEITRYFLDRIKQQDPTYNCYVTVTEELAMAQAKAADARLAAGNAPTMCGVPFAHKDIFCTNGVKTTCGSKMLDNFVPPYNATVVENYINEGAVMLGKTNMDEFAMGSSNETSYFGPVKNPWDTNCVPGGSSGGSAAAVAARMAPGATATDTGGSIRQPAALCGITGIKPTYGRVSRWGMIAFASSLDQAGVMARSAEDAAIMLNVMAGYDNKDSTCIDEPVPDYIANLGDSLAGVTIGVPKEYFEVGLNPGTEARVQDAIKQYETAGAKIKSISLPHSHLAVPAYYVIAPAECSANLSRFDGVRYGHRCDDPKDLMDLYKRSRGEGFGEEVKRRILVGTYCLSAGYYDAYYGKSQQVRRLIKQDFVDAFKEVDVIMGPTAPSPAFAFGSKGDDPVAMYLEDIYTIATNLAGLPGMSVPCGLVDNKPVGLQLIGNFFAESKLLNLAHQFQLATDFHTLAPSSLA
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: IF4E1_CUCZE
Sequence: MVVEDTIKATSAEDLSNSIANQNPRGRGGEEDEELEEGEIVGDDDLDSSNLSAALVHQPNPLEHSWTFWFDNPSAKSKQATWGASIRPIYTFSTVEEFWSVYNNIHHPSKLAMRADLYCFKHKIEPKWEDPVCANGGKWTVNFPRGKSDNGWLYTLLAMIGEQFDCGDEICGAVVNVRSGQDKISIWTKNASNEAAQASIGKQWKEFLDYNESIGFIFHDDAKKFDRHAKNKYMA
What is the function of this protein?
(Microbial infection) Susceptibility host factor required for viral infection by recruiting viral RNAs to the host ribosomal complex via an interaction with viral genome-linked protein (VPg).
What are the official names of this protein?
Eukaryotic translation initiation factor 4E-1, Cz-eIF4E-1, eIF-4E-1, eIF-4F 25 kDa subunit, eIF-4F p26 subunit, mRNA cap-binding protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: Y609_ARCFU
Sequence: MERMVVDSKVMVGKPVIKGTRIPVDANVRIRNLQFY
What are the official names of this protein?
Uncharacterized protein AF_0609.
Protein: MNME_METPB
Sequence: MTDALPVREETIFAPASGFGRAAVAVVRVSGPAAGPALDQLAGGRPEPRRLSLRRLRDPGTGNILDQALVAWLPGPATATGEDMAELHLHGGLAVRAAVLRALGRVPGCRPAEAGAFSRRAFLNGRIDLTEAEGIADLIDAETEAQRVQALRQLDGALGRQVAAWRETGIELLAGAEAALDFADEGDVDEDGLDAALAGRAAALRDAIRAALADGRRGERLREGFCVVLAGAPNAGKSTLLNALSGRDAAIVSDIPGTTRDAIEVRCDLGGLPVVLVDTAGLRETADVIEAEGVRRTHHRIRSADLVLHLVPADGEAGPEDFAEVPVLRVRTKSDLPSGAPGEGGLAVSAVTGAGLDALLDAIQGSAASALGGGDALVTRERHREALSRAAGHLDRVATAPAGFPPELVAEDLRLAVRALGEVGGHVGVEEMLDRLFAGFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.