PharMolix/UniProtQA huggingface dataset:
Protein: PSBI_SYNP6
Sequence: MLALKVTVYVVVLFFVALFVFGFLSSDPARTPSRKDLED
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.4 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: KDSA_HAEIN
Sequence: MQNKIVKIGNIDVANDKPFVLFGGMNVLESRDMAMQVCEAYVKVTEKLGVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDTFGVKIITDVHEIYQCQPVADVVDIIQLPAFLARQTDLVEAMAKTGAVINVKKPQFLSPSQMGNIVEKIEECGNDKIILCDRGTNFGYDNLIVDMLGFSVMKKASKGSPVIFDVTHSLQCRDPFGAASSGRRAQVTELARSGLAVGIAGLFLEAHPNPNQAKCDGPSALPLSALEGFVSQMKAIDDLVKSFPELDTSI
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2031_CORGL
Sequence: MKTQKQYLGAFGEDVALQQYLDDQATLLDRNVRYSCGELDLIVRSASGVVVFVEVKTRRGSAFDSAAAVNNQKMLRMRRAAALWLEGKPYTPIRFDVVAIVLDPHTGRPEITVYEDVEHGAR
What are the official names of this protein?
UPF0102 protein Cgl2031/cg2228.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: DLTA_STAA8
Sequence: MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEMCLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVNRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERPGARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKVIHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIAEVING
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSUD_PSEPG
Sequence: MSLNIFWFLPTHGDGKYLGTSDGARAVDHGYLQQIAQAADRLGFGGVLIPTGRSCEDSWLVAASLIPVTQRLKFLVALRPGIISPTVAARQAATLDRLSNGRALFNLVTGGDPDELAGDGLHLNHQERYEASVEFTRIWRKVLEGENVDYDGKHIQVKGAKLLYPPIQQPRPPLYFGGSSEAAQDLAAEQVELYLTWGEPPSAVAEKIAQVREKAAAQGREVRFGIRLHVIVRETNEEAWAAADRLISHLDDDTISRAQASLARFDSVGQQRMAALHGGNRDNLEVSPNLWAGVGLVRGGAGTALVGDGPTVAARVKEYAELGIDTFIFSGYPHLEESYRVAELLFPHLDVQRPEQPKTGGYVSPFGEMVANDILPKSVSQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: Y2563_MYCTO
Sequence: MLFAALRDVQWRKRRLVIAIVSTGLVFAMTLVLTGLVNGFRVEAERTVDSMGVDAFVVKAGAAGPFLGSTPFAQIDLPQVARAPGVLAAAPLATAPSTIRQGTSARNVTAFGAPEHGPGMPRVSDGRAPSTPDEVAVSSTLGRNLGDDLQVGARTLRIVGIVPESTALAKIPNIFLTTEGLQQLAYNGQPTISSIGIDGMPRQLPDGYQTVNRADAVSDLMRPLKVAVDAITVVAVLLWIVAALIVGSVVYLSALERLRDFAVFKAIGVPTRSILAGLALQAVVVALLAAVVGGILSLLLAPLFPMTVVVPLSAFVALPAIATVIGLLASVAGLRRVVAIDPALAFGGP
What are the official names of this protein?
Uncharacterized ABC transporter permease MT2639.
What is the protein family that this protein belongs to?
Belongs to the ABC-4 integral membrane protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACYLT_MYCS2
Sequence: MTLSGRIPLGGQVTDLGYAAGWRLVRAMPEAMAQGVFGAGARYAARNGGPEQLRRNLARVVGKPPADVPDDLIRASLASYARYWREAFRLPAMDHGRLGEQLDVIDIDHLWSALDAGRGAVLALPHSGNWDMAGVWLVQNYGPFTTVAERLKPESLYRRFVEYRESLGFEVLPLTGGERPPFEVLAERLTDNRPICLMAERDLTRSGVQVDFFGEATRMPAGPAKLAIETGAALFPVHCWFEGDGWGMRVYPELDTSSGDVTAITQALADRFAANIATYPADWHMLQPQWIADLSDERRARLGT
What is the function of this protein?
Catalyzes the transfer of a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring linked to the 2-position of myo-inositol in phosphatidyl-myo-inositol monomannoside (PIM1) or dimannoside (PIM2).
What are the official names of this protein?
Phosphatidylinositol mannoside acyltransferase, PIM acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LpxL/LpxM/LpxP family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Permanently associated with the membrane.
Protein: SIGA1_SYNE7
Sequence: MTQLISIDKEQEEAGMTQATELLDPALKPAETKAKRSSRKKATTAVVEPATTIAPTADVDAIDDEDSVGEDEDAAAKAKAKVRKTYTEDSIRLYLQEIGRIRLLRADEEIELARQIADLLALERIRDELLEQLDRLPSDAEWAAAVDSPLDEFRRRLFRGRRAKDKMVQSNLRLVVSIAKKYMNRGLSFQDLIQEGSLGLIRAAEKFDHEKGYKFSTYATWWIRQAITRAIADQSRTIRLPVHLYETISRIKKTTKLLSQEMGRKPTEEEIATRMEMTIEKLRFIAKSAQLPISLETPIGKEEDSRLGDFIEADGETPEDEVAKNLLREDLEGVLSTLSPRERDVLRLRYGLDDGRMKTLEEIGQLFNVTRERIRQIEAKALRKLRHPNRNSILKEYIR
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA1.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_STRR6
Sequence: MSVREKMLEILEGIDIRFKEPLHSYSYTKVGGEADYLVFPRNRFELARVVKFANQENIPWMVLGNASNIIVRDGGIRGFVILCDKLNNVSVDGYTIEAEAGANLIETTRIALRHSLTGFEFACGIPGSVGGAVFMNAGAYGGEIAHILQSCKVLTKDGEIETLSAKDLAFGYRHSAIQESGAVVLSVKFALAPGTHQVIKQEMDRLTHLRELKQPLEYPSCGSVFKRPVGHFAGQLISEAGLKGYRIGGVEVSEKHAGFMINVADGTAKDYEDLIQSVIEKVKEHSGITLEREVRILGESLSVAKMYAGGFTPCKR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PILU_PSEAE
Sequence: MEFEKLLRLMVEKGGSDLFITAGVPPSMKVNGRVMPVTKTPLSPEQTRETVLGVMNEQQRRDFAENHECNFAISARGIGRFRVSAFYQRNLVGMVLRRIETNIPTLEELKLPEILKKLALTKRGLVIFVGATGTGKSTSLAAMIGYRNKNSTGHIISIEDPIEYIHQHQGCIVTQREVGLDTDSFEVALKNTLRQAPDVIMIGEVRSRETMDHAVAFAETGHLCLATLHANNANQALERIIHFFPADRHGQVWMDLSLNLKAIVAQQLVPTPDGKGRRAVIEVLLNTPLAADLIRKGEVHELKPLMKRSTEQGMQTFDQALYQLYTQGEITYEDALAHADSANDLRLMIKLGSESDADHLSSLTQGLSLEITDDDPAGRRFR
What is the function of this protein?
ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers (PubMed:7854122, PubMed:10377148, PubMed:15659660, PubMed:18174131).  Functions as a PilT-dependent retraction ATPase, providing a functional coupling between PilT and PilU and an optimal mechanism for pilus retraction (PubMed:31525185, PubMed:31626631).
What are the official names of this protein?
Type IV pilus ATPase PilU.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes only to the piliated pole.
Protein: ARGR_SHEWM
Sequence: MQAAKTQDELVKTFKAILKEERFGSQSEIVIALQAEGYNNINQSKVSRMLSKFGAVRTRNAKQEMVYCLPAELGVPTAGSPLKNLVLDVDHNQAMIVVRTSPGAAQLIARLLDSIGKPEGILGTIAGDDTIFITPSNIQEIDKTLITVKSLFNFTN
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPOL_WHV2
Sequence: MHPFSRLFRNIQSLEEEVQELLGPPEDALPLLAGEDLNHRVADALNLHLPTADLQWVHKTNAITGLYSNQAAQFNPNWIQPEFPELHLHNDLIQKLQQYFGPLTINEKRKLQLNFPARFFPKATKYFPLIKGIKNHYPNFALEHFFATANYLWTLWEAGILYLRKNQTTLTFKGKPYSWEHRQLVQHNGQQHKSHLQSRQNSSMVACSGHLLHNHLSSESVSVSTRNLSNNISDKSQKSTRTGLCSYKQIQTDRLEHLARISCGSKIFIGQQGSSPKTLYKSISSNFRNQTWAYNSSRNSGHTTWFSSASNSNKSRSREKAYSSNSTSKRYSPPLNYEKSDFSSPGVRRRITRLDNNGTPTQCLSRSFYNTKPCGSYCIHHIVSSLDDWGPCTVTGDVTIKSPRTPRRITGGVFLVDKNPNNSSESRLVVHFSQFSRGHTRVHWPKFAVPNLQTLANLLSTNLQWLSLDVSAAFYHIPISPAAVPHLLVGSPGLERFNTCLSSSTHNRNNSQLQTMHNLCTRHVYSSLLLLFKTYGRKLHLLAHPFIMGFRKLPMGVGLSSSLLAQFTSALASMVRRNFPHCVVFAYMDDLVLGARTSEHLTAIYSHICSVFLDLGIHLNVNKTKWWGNHLHFMGYVITSSGVLPQDKHVKKISRYLLSVPVNQPLDYKISERLTGILNYVAPFTLCGYAALMPLYHAIASRMAFIFSSLYKSWLLSLYEELWPVVRQRGVVCTVFADATPTGWGIATTCQLLSGTYAFPLPIATAELIAACLARCWTGARLLGTDNSVVLSGKLTSFPWLLACVATWILRGTSFCYVPSALNPADLPSRGLLPALRPLPRLRLRPQTTRISLWAASPPVSPRAPVRVAWSSPVQTCEPWIPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: ICA_APICA
Sequence: MKTLGVLFIAAWFIACTHSFPGAHDEDSKEERKNVDTVLVLPSIERDQMMAATFDFPSLSFEDSDEGSNWNWNTLLRPNFLDGWYQTLQSAISAHMKKVREQMAGILSRIPEQGVVNWNKIPEGANTTSTTKIIDGHVVTINETTYTDGSDDYSTLIRVRVIDVRPQNETILTTVSSEADSDVTTLPTLIGKNETSTQSSRSVESVEDFDNEIPKNQGDVLTA
What are the official names of this protein?
Icarapin, Venom protein 2.
What are the subcellular locations of this protein?
Secreted.
Protein: TIM9_MESCR
Sequence: MDKNMLGDLDNLPEEDKLKMASMIEQLQIRDSLRMYNNLVERCFTDCVDSFRRKTLDKQEETCVKRCAEKFLKHSMRVGLRFAELNQGAATTD
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim9.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: HSLU_BRUSI
Sequence: MSNFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFVKVEATKFTEVGYVGRDVEQIIRDLVEIAITLVREKRREDVKAKAHLNAEERVLDALVGKTASPATRDSFRKKLRNGEMDDKEIEIEVSDSGASPNFEIPGMPGANIGVLNISDMLGKAMGGRTKTRKTTVKDSYPILINDESDKLLDQDQIVQEALRVSEDEGIVFIDEIDKIAAREGGSGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHILFITSGAFHVSKPSDLLPELQGRLPIRVELSALTREDFRRILTETEASLIKQYIALMETEEVKLEFSDDAIDALADIAVDLNATVENIGARRLQTVMEKVLDEISFTAPDKAGATFIIDAAYVKEKIGGLAKNTDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_CHLPN
Sequence: MSELIIGVDPGTIVAGYAIIAVEQRYQLRPYSYGAIRLSSDMPLPMRYKTLFEQLSGVLDDTQPNAMVLETQFVNKNPQSTMKLAMARGIVLLAAAQRDILIFEYAPNVAKKAVVGKGHASKRQVQVMVSKILNVPEVLHPSNEDIADAFALAICHTHVARSPLCGVR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: SYDND_LACP7
Sequence: MAESMKGLHRTHRCTELSNSNVGEIVTVMGWVQKSRNKGGIIFVDLRDRSGLLQIIFEEGDIGTEMFEKASKLRSEFVVAVVGKVETRSGAVNENLLTGTIEVRATELRILSESETPPFPIEEGSKTKEELRLKYRYLDLRRPDLVRNLMLRSKVATLTRQFLSDEGFLEIETPMLTKSTPEGARDYLVPSRVHPGNFYALPQSPQIFKQLLMVSGYDRYFQIVKCFRDEDLRADRQPEFTQIDMELSFVDVDDVISVNERLLQKMFKESIGIDVSLPIQRMTWREAMDRYGSDKPDTRFGMELKNVSELVKDCGFAVFTGALENGGSVRGINANGQGEMPRKKIDALIEFAKGYGAKGLAYLSINEDGTYKSSFSKFMTEEELSALVAAMEAKPGDLLFFAADKDKVVFDVLGNLRLEIARNLELLDKNTYNFLWVTEFPLLEYSEEEGRYTAMHHPFTMPMDEDLPLLETDPGKVRAKAYDIVLNGTEVGGGSVRIFQNNVQEKMFEVLGFTKEEAYERFGFLLNAFKYGVPPHAGLAYGLDRLVMLMAKEDSIRDVIAFPKVKDASCLLTDAPNVVDDKQLEELSIALAKKATEE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_HYDS0
Sequence: MIGYVLKKILGTKNDREIKKIRKWVEKINALEESLDKLSNKDIVLKAQDLYFRVNQNEHIKQAIIEGEMVEELIEAFALVREASKRTMGLRQFDVQLIGGIVLYQGKIAEMKTGEGKTLVAAAPAFFTALTDTGVHVVTVNDYLAKRDATWIGPIYRFLGLDVGVINSDNMSYIIDWQDPEKAMEAIEKDIRVWPKGMVGDAIDYSKIDVHAKTSYFTKAISVERAKAYEAHITYGTNNEFGFDYLRDNLAVSKDQIVQVKGHGYAIVDEIDSILIDEARTPLIIAGPSNLDNKVVLQANEFVQTLEIEKDFIVDEKNRTAMLTEEGIEKAEKYFNIQNLYDIRHIDLVHAINKALLAHNLYKKDVHYMVKDGEILIVDEFTGRALPGRRWSEGLHQAIEAKEGVEIQEENQTLATTAFQNYFKLYKKLAGMTGTAETEALEFKEIYSLDVVVIPTNKPNIRKDLPDAIFKTKKEKWEYIAKVIEENHAKGRPILVGTVSIEDSETLSKLLEQRGIKHNVLNAKQHEKEAWIIAQAGRKGAVTIATNMAGRGTDILLGGNPEFLAREILKQKGIDEDKATEEEWKQAYEEATKITQKEKEEVIKAGGLLVIGTERHESRRVDNQLRGRAGRQGDPGESRFILSLEDDLLRIFGGDRVKKLMEFMKIPEGEPIESSIVSKSLEGAQERVELQNFQSRKRLLEYDEVINIQRSVVYDIRRSILFQDDIKEEIKDFIKDVIHTQVFTLLTEDEPELWELEPLKTFFKEWIDLDLPEKFEAKDREELEEEIFKLVMEKYAQKEQEIGEKTMREIEKVFTLNIIDNLWREQLHTIDKLREGIYLRSYAQRDPLVEFKKEAFRLFEELMLNFKISAIQSIMNAQISKEELEQQEQNMFNLEIDTLNKSMAISEALENIAKEFQEKRPRFRTLKDRLEERKKKLEKKGESA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: GAR1_CHAGB
Sequence: MSFRGAPRGRGGGGFGGGRGGGRGGFQQRDMGPPATVLEMGKFIHACEGEMVIESTNPKVPHFNAPIYLENKTAVGKVDEVLGPINQVYFTIKPSEGIQATSFKYGDKFYIAGEKLLPLERFLPKPKPPPGTVSKVKKPSRGGAARGGRGGPGGGFSRGGGRGGGRGGFGGSRGGGGFGGGFGGGRGGAPRGGRGGFSRGGGRGGGRGRF
What is the function of this protein?
Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.  The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs.  The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit GAR1, snoRNP protein GAR1.
What is the protein family that this protein belongs to?
Belongs to the GAR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TILS_EXIS2
Sequence: MEFEIHLPKEPLLVAVSGGCDSMVLAHLLYEANHDLMIVHVHHGLRKESDEEAEAVRAWAEARRVGIRMTRLEWEGQAPSQAACRTRRYAFFQEVMAETGRRHLVLAHHRDDQLETLLIQLIRGEAGVDGIPRIRSFATGQIHRPLLPYSKQQLYDYAKARQVVWHEDETNAGTKYLRNQMRHRLLPLLAELRPGYEEATVQAAMVRYEQKQEHLKYVTSYVKEQMTDRGLPLEAIQKLPTDFRRLVLRALLPDHDFTSEDYNRFLTLLRVDMPSGEVYYGNWRIQRTYGYVTCVRCPEKNLLPEALEVGIDLGTYHYGEQTITFSRTTTGIPFSAVQFPLTIRSVLPGDRIRLAVGTKKVSRILVDAKVPRASRAEIPVVVDAAGQVLAVIGHRIAIFGSFELLAESCLMIEW
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_PSYWF
Sequence: MCPSFHTTASVTTASNQADSDFNLAKLITAPAQLLAHNTMRLSCQAMQLITLEQEAQVEPAIAKLKEGDAPLFVLSGGSNVILPKQLQAQVLHPVFKGIEVLAEDEHSVSLEVMGGENWHELVLYTVNNGWYGLENLALIPGLVGASPVQNIGAYGVQLEDCLTHIKAFHLPTQKWHDFDKADCQFNYRDSLFKQQAGQWLITRVGFKLHKDATQVNADYGDVACLALSLAQADNRSAIGPIDVMHAIIDIRQSKLPDPAVLPNCGSFFKNPIIGTEQFAQLQHEYPGIVGYRVDEAHTKVAAGWLIDTAGLKGQGINPILTHAKQALVLVNHSALDSTTPASQADILATQQFIQRSIKDKFGIELEREPVWVDEQASYTAAP
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_EXIS2
Sequence: MEWLEVAKIANTHGLKGELKLLASTDFPEQRFKVGNEVFLESNGIYTPFMISSYRKHKQFIMVTFKGMQHINDVEKYKGLKLYVHPEALQELGEHEFYYHEIIGCTVFDGEDEIGVVSEILETGANDVWTIKRPGKKDVLIPYIEQVVASIDVEAKRIQITPLPGLIEG
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_SHESR
Sequence: MAVIKCKPTSPGRRHVVKVVNSDLHKGKPFAGLLAKKSKSGGRNNTGRITVRHVGGGHKQHYRLIDFKRDKDGIPAKIERLEYDPNRTAHIALVLYADGERRYILAAKGMQAGDKIQSGVEAEIKTGNAMPLRNIPVGSVVHAVEMKPGKGAQIARSAGAYVQVVARDGAYATLRLRSGEMRKVPVDCRATFGEVGNAEHMLRQLGKAGAKRWRGVRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVTPWGVPTKGYKTRSNKRTDKYIVRRRNK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DCDB_SULSY
Sequence: MILNDKTIRKYISEGLLEINPLDDIQIQPSSVDLRLGNEFLIYPEDIEIIDVRDPYFSNRLIKEIATEEGFIIKPKQFVLATTIEYIKLPDFLTAFVEGRSSLGRLGLFIENAGWVDAGFEGNITLEFYNANSIPIKIYPGMRICQLVFAKMEDRSEKPYRGKYQGQRGTTASRIFLDRD
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: VRAR_STAA8
Sequence: MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
What is the function of this protein?
Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis.  Upon cellular stress, the histidine kinase VraS transfers the phosphoryl group onto VraR.  Upon phosphorylation, VraR dimerizes at the N-terminal domain.  In turn, phosphorylation-induced dimerization expand and enhance the VraR binding to its own promoter leading to increased expression and subsequent modulation of as many as 40 genes, which ultimately constitute the S. aureus response to cell wall damage (PubMed:31277575).  In addition, inhibits the host autophagic flux and delays the early stage of autophagosome formation, thereby promoting bacterial survival.  Facilitates the ability of S. aureus to resist host polymorphonuclear leukocytes-mediated phagocytosis and killing thus contributing to immune evasion (By similarity).
What are the official names of this protein?
Response regulator protein VraR.