PharMolix/UniProtQA huggingface dataset:
Protein: CT1BA_BACTW
Sequence: MKESIYYNEENEIQISQGNCFPEELGHNPWRQPQSTARVIYLKVKDPIDTTQLLEITEIENPNYVLQAIQLAAAFQDALVPTETEFGEAIRFSMPKGLEVAKTIQPKGAVVAYTDQTLSQSNNQVSVMIDRVISVLKTVMGVALSGSIITQLTAAITDTFTNLNTQKDSAWVFWGKETSHQTNYTYNVMFAIQNETTGRVMMCVPIGFEIRVFTDKRTVLFLTTKDYANYSVNIQTLRFAQPLIDSRALSINDLSEALRSSKYLY
What is the function of this protein?
Kills the larvae of dipteran insects by making pores in the epithelial cell membrane of the insect midgut.
What are the official names of this protein?
Type-1Ba cytolytic delta-endotoxin.
What is the protein family that this protein belongs to?
Belongs to the cyt1/cyt2 endotoxin family.
Protein: GUNA_PAELA
Sequence: MKTRQRKRLFVSAALAVSLTMTVPMPASVNAAASDVTFTINTQSERAAISPNIYGTNQDLSGTENWSSRRLGGNRLTGYNWENNASSAGRDWLHYSDDFLCGNGGVPDTDCDKPGAVVTAFHDKSLENGAYSIVTLQMAGYVSRDKNGPVDESETAPSPRWDKVEFAKNAPFSLQPHLNDGQVYMDEEVNFLVNRYGNASTSTGIKAYSLDNEPALWSETHPRIHPEQLQAAELVAKSIDLSKAVKNVDPHAEIFGPALYGFGAYLSLQDAPGWPSLQGNYSWFIDYYLDQMKNAHTQNGKRLLDVLDVHWYPEAQGGGQRIVFGGAGNIDTQKARVQAPRSLWDPAYQEDSWIGTWFSSYLPLIPKLQSSIQTYYPGTKLAITESSYGGDNHISGGIATADALGIFGKYGVYAANYWQTEDNTDYTSAAYKLYRNYDGNKSGFGSIKVDAATSDTENSSVYASVTDEENSELHLIVLNKNFDDPINATFQLSGDKTYTSGRVWGFDQTGSDITEQAAITNINNNQFTYTLPPLSAYHIVLKADSTEPVNSDLVVQYKDGDRNNATDNQIKPHFNIQNKGTSPVDLSSLTLRYYFTKDSSAAMNGWIDWAKLGGSNIQISFGNHNGADSDTYAELGFSSGAGSIAEGGQSGEIQLRMSKADWSNFNEANDYSFDGAKTAYIDWDRVTLYQDGQLVWGIEP
What are the official names of this protein?
Endoglucanase A, Cellulase A, EG-A, Endo-1,4-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 44 (cellulase J) family.
Protein: RS10_FRATM
Sequence: MAINNQRIRIRLKAFDHKLIDISTQEIVDTAKKTGAQVKGPIPLPVRKERFTILISPHVNKKARDQYEIRTHKRLIDIVEPTDKTVDALMKLDLASGVDVQISLS
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: SYS_CARHZ
Sequence: MLDIKKVRQNPEIVVEALKKRGANLNLDEFLRLDEERRKLLVDVEQKKYKRNTVSEEIGRLKKQGLPADDLILEMRALSDEIKKLDDEVAQIEEKLHAILLTIPNIPHESVPVGKDSSENVEVRRWGEPRKFTFTPKAHWEIGEELDILDFARGSKVTGARFTFYKGLGAMLERAVINFMLDLHTREHGYVEVFPPFIVNADSMMGTGQLPKFAEDMFKLEGLNYYLIPTAEVPVTNLYREEILDGDKLPIYHCAYSACFRAEAGAAGRDTRGLIRQHQFNKVELVKFVKPENSYEELEKLTRDAERVLQLLGLPYRVVVLCTGDLGFSAAKTYDIEVWLPSYNDYKEISSCSNFEDFQARRAKIRYKEHPKAKPEFVHTLNGSGLAVGRTVAAILENYQNEDGSVTVPEVLRPYMGVDRIYKK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_STAAU
Sequence: MTNKDESVEKNTESTVEETNIKQNIDDSVEQAEESKGHLQDEAIEETSDENVIEEIDPKDQKINELQQLADENEEKYLRLYAEFENYKRRIQKENEINKTYQAQRVLTDILPAIDNIERALQIEGDDETFKSLQKGVQMVHESLINALKDNGLEVIKTEGEAFDPNIHQAVVQDDNPDFESGEITQELQKGYKLKDRVLRPSMVKVNQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSC_YERPE
Sequence: MARKRIAFIFTQGPHGSSAGREGLDALLATSALSEDIGVFFISDGVLQLLPQQQPEKILARNYIATFGVLPLYDVENCYLCERSLQQRGLSKMADWILDVTVLSPADLRRELGTYDVVLTF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_METTM
Sequence: MNYAEMFSRVEGCAFVPFVVAGDPDMETSVEIIRTLVDAGADALEIGFPFSDPIADGTSVQEADLRALNSGMTTDDCFRLIERIREFTSVPVGLLVYYNLIYRMGADEFYRRAAEAGVTGILAADLPPEEAGDALRAAERYGIDQIFIVAPTTDNQRLKMISEVSSGFHYLVSVMGVTGARSRVEESTLELIERVKGAGSLPVMVGFGVSQPEHVRMLADAGADGVIVGSAIIDLISKNLDDRERMLQEIYEMVRKMKTAAGGSR
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: YBED_SALNS
Sequence: MKTKLNELLEFPTPFTYKVMGQALPELVDQVVEVVQRHAPGDYSPTVKPSSKGNYHSVSITINATHIEQVETLYEELGNIDIVRMVL
What are the official names of this protein?
UPF0250 protein YbeD.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: RAB6A_HUMAN
Sequence: MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC
What is the function of this protein?
Regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623).  Has a low GTPase activity (PubMed:25962623).  Recruits VPS13B to the Golgi membrane (PubMed:25492866).  Plays a role in neuron projection development (Probable).
What are the official names of this protein?
Ras-related protein Rab-6A, Rab-6.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid- anchor. Note=BICD2 facilitates its targeting to Golgi apparatus membrane. SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane; Lipid-anchor. SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane; Lipid-anchor.
Protein: MED4_HUMAN
Sequence: MAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSSSESD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 4, Activator-recruited cofactor 36 kDa component, ARC36, Mediator complex subunit 4, TRAP/SMCC/PC2 subunit p36 subunit, Vitamin D3 receptor-interacting protein complex 36 kDa component, DRIP36.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SLIB_RAT
Sequence: MPLWVFFVLLTLTSGSHCSLPPSPPFRVRRHADAIFTSSYRRILGQLYARKLLHEIMNRQQGERNQEQRSRFNRHLDRVWAEDKQMALESILQGFPRMKLSAEA
What is the function of this protein?
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
What are the official names of this protein?
Somatoliberin, Growth hormone-releasing factor, GRF, Growth hormone-releasing hormone, GHRH.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: DHOM_PSEAE
Sequence: MKPVKVGICGLGTVGGGTFNVLERNAEEIARRAGRGIEVAQIAARRPNPKCDTGATPITADIFDVACNPEIDVVVELIGGYTLAHELVLKAIENGKHVVTANKALIAVHGNEIFAKAREKGVIVAFEAAVAGGIPVIKAIREGLSANRINWLAGIINGTGNFILSEMREKGRTFPDVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIAFGIPLQFDKAYTEGISKLTSADVNYADALGYRIKHLGVARRTESGFELRVHPTLIPSDRLIANVNGVMNAVMVNGDAVGSTLYYGAGAGMEPTASSVVADLVDVVRAMTSDPENRVPHLAFQPDALSDHPILPIEACESAYYLRIQAKDHPGVLAQVATILSERGINIESIMQKEAEEQDGLVPMILVTHRVIEQRINDAIAALEALEGVSGPVVRIRVEQLN
What are the official names of this protein?
Homoserine dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the homoserine dehydrogenase family.
Protein: UB10B_XENLA
Sequence: MASPSGQYIFGEFSDDEFKQFFVTARCTVELPPYNEHFFPCGPQSSVDFQDDMHLKFSEVIHGISGEECPRIEFGIEQVVDRDTALNNNTDYSISSNLNPQAPEFILTCSSFPKTSNNVLHENNFDAINCQFSESAIPDGSGNADSDGTSGTGQRERKKKKKRPPGYYSYLEGVGDVPSETLVNGHANSTGLDSISTDDPDLADDIPISTTSPRTCTSPDNFVDLINEALSDEASMHNVLDNARTAGQPEECSVTSSEQSCIPSDNGSESPVRTAVVQPFAGTDTTENLGVTNGQTLESPEEDTVSNGVVLHPEVSSFSEEVKTEETSTAQALIHLSGSASSNPPAKSWASLFHTSKPSSSPQVAYVETKNAPTVVSPQVPEKQVEIKEEPVPVSDDPVAIEFAELLEEVKLVHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKSIPVYTKAQRPCTSTPMIDSFVRLMNEFTNMPILPKAKQAPGEKVIKDIRPGAPFEPTYIYRLLTVFKSSLSEKGRQEDAEEYLGFILNGLHEEMLALKKLLLPQNDQIHINNCPNPVSGVEEVNKEEQEGSDEEWEQVGPRNKSSVTRQADFVQTPITDIFGGHMRSVVYQQSSKESATLQPFFTLQLDIQSEKIRTVQDALESLVARESVQGYTTKTKQEVEICRRVTLEELPPVLVLHLKRFVFEKTGGCQKLIKNIEYPVDLEVSKDLLSPGVKSKIFKGQRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQSVKVINQYQVVKQTVERTAYLLYYRRVDLL
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/tp53.  Acts as an essential regulator of p53/tp53 stability: in unstressed cells, specifically deubiquitinates p53/tp53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/tp53.  Following DNA damage, translocates to the nucleus and deubiquitinates p53/tp53, leading to regulate the p53/TP53-dependent DNA damage response.  Component of a regulatory loop that controls autophagy and p53/tp53 levels (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 10-B, Deubiquitinating enzyme 10-B, Ubiquitin thioesterase 10-B, Ubiquitin-specific-processing protease 10-B.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP10 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: KAO1_ARATH
Sequence: MAETTSWIPVWFPLMVLGCFGLNWLVRKVNVWLYESSLGENRHYLPPGDLGWPFIGNMLSFLRAFKTSDPDSFTRTLIKRYGPKGIYKAHMFGNPSIIVTTSDTCRRVLTDDDAFKPGWPTSTMELIGRKSFVGISFEEHKRLRRLTAAPVNGHEALSTYIPYIEENVITVLDKWTKMGEFEFLTHLRKLTFRIIMYIFLSSESENVMDALEREYTALNYGVRAMAVNIPGFAYHRALKARKTLVAAFQSIVTERRNQRKQNILSNKKDMLDNLLNVKDEDGKTLDDEEIIDVLLMYLNAGHESSGHTIMWATVFLQEHPEVLQRAKAEQEMILKSRPEGQKGLSLKETRKMEFLSQVVDETLRVITFSLTAFREAKTDVEMNGYLIPKGWKVLTWFRDVHIDPEVFPDPRKFDPARWDNGFVPKAGAFLPFGAGSHLCPGNDLAKLEISIFLHHFLLKYQVKRSNPECPVMYLPHTRPTDNCLARISYQ
What is the function of this protein?
Catalyzes three successive oxidations of ent-kaurenoic acid giving gibberellin 12 (GA12), a key step in gibberellins (GAs) biosynthesis.  GAs, which are involved many processes, including stem elongation, play a central role in plant development.
What are the official names of this protein?
Ent-kaurenoic acid oxidase 1, AtKAO1, Cytochrome P450 88A3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: SAHH_CAUVC
Sequence: MADYIVKDISLADFGRKEIAIAETEMPGLMATRAEYGPQQILKGARIAGSLHMTIQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAIAAAGVPVFAFKGENLVEYWEYAHKIFEWHDGGYPNLILDDGGDATLLCVLGPKAEKDPSILNNPQNEEEEALYAVMKKYLAEKPGFYSAIRAAIGGVSEETTTGVHRLYQMAQKDELPFPAINVNDSVTKSKFDNLYGCRESLVDAIRRGTDVMLSGKVAVVCGYGDVGKGSAASLRQGGARVIVTEVDPICALQAAMEGYEVQTLNDVADKADIFVTATGNKDVITVDDMRKMKNNAIVCNIGHFDSEIQIAGLRNFKWDEIKPQVHHVEFPDGKKLIVLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELWTNKAKYENQVYTLPKHLDEKVAFLHLEKLGAKLTTLRKDQADYIGVPEAGPFKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_SHEPW
Sequence: MENTADITVLGAGSYGTALAISLASNGHRTLLWGHEPEHIENLKNDKCNQEFLPGIPLPDLLIPESDLATALAASNNVLVVVPSHVFGLVLAQAKPLLRKDARIVWATKGLEPETGRLIQDVAREVLGEAFPLAVLSGPTFAKELAAGMPTAISIAGTDPQFTSDLVELLHSPKRLRVYANDDFIGLQLGGAVKNVIAIGAGLSDGIGFGANARTALITRGLVELTRLGEAIGAQASTFMGMAGLGDLVLTCTDNQSRNRRFGLALGKGSDVEAAQIEIGQVVEGYRNTKEVYTLAKRLGVEMPITEQVYQVLYQGKSPVDAAKELLSREKKSETSAE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_PROM0
Sequence: MKGKNYKIVSLYSFFPFQENLILDLKNKLIEIENENDLSGLFIFANEGINGTICAEKNVIDIVINLINTYTDNKNLNIKVNFSKNKVFKKLKIKIKKEIVTMGIPEINPSENNGTYIDSADWNKLIKNKNTIVIDTRNHYEVSIGTFQNSINPNTKNFSEFPKWVDDHLDTHLENKDSTNIAMFCTGGIRCEKATTLLKKKGYKNVYHLQGGILQYLDDIPKEKNLFEGECYVFDKRVALDQELEKGSYSICHACGMPVSIQDQERKEYRKGIQCHFCIDQFSEDDRKRFEERQKQIDRLKVENHKIHKE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: MTMR3_RAT
Sequence: MRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEYVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFPTFEQCQDWLKRLNNAIRPPGKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRNSCRGFPNAGDLSDVEFDASLSNASGTESLALQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPSTPTDDSCAPYPAPGTSPDEPPLSRLPKTRSFDNLTTTCDNMVPLASRRSSDPSLNEKWQEHGRSLELSSFAGSGEEVPAIDSLRRPSRLLGGAELSVAAGVAEGQMENILQEATKEESGVEEPTHREHTEVPEVKEEAPLAKESRTAAQGSGVLYQEPQLDDATLRSHLGPSLSSFSQGIPEHREVGHSVLSSSLPASLRGEDSQEVPVEQPQVENIAEDRENVVPAVPVDVKIGLGTSESSPLLPSQVPFETRGPHMNNSVHMLLEDKVKSESGPQLHHRPCLASSGRFSGKDMLPIAPEPRSAERPQWDSVLHRTSSPGNTLSLMMQAPCALPLDKCRQRIVCNGALETENKASEQPAGFDTLQKYPTPNGHCANGETGRSKDSLSHQLSATSYSSAHSCSRNLHHKWLNSHSGRPSTTNSPEQPSRSHLDDDGMPVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLRFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
What is the function of this protein?
Phosphatase that acts on lipids with a phosphoinositol headgroup.  Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate.  May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity).
What are the official names of this protein?
Myotubularin-related protein 3, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: RSMH_DEHM1
Sequence: MTEYPHIPVMLEESIQGLGVIPGGRYVDCTLGAGGHSEAILEHSYPGGQLLSIDADPKAIALAAERLKCFGSSVLLVNDNFANLKDICQRYEYMPVHGILFDLGLSSMQLDREESGFSFQTEAPLDMRFSPGQELSAADIVNTYDLAGLSDLIWKYGEEPFSRRIARAILEKRPFKTTTELASVIEKAVGGRHGRIHPATRTFQALRIAVNEELSHLESALAQAQSLLGHGGRLVVISYHSLEDRIVKQYFQKEAKGCICPDDIPQCVCNHKPSLRLINRRVITPSDEEISRNPRSRSAKMRVAERIIQPGEGRFFHSRAKGLVNHVSETGSVRYGQAKHKGVVQRGGS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_VILV
Sequence: MASKESKPSRTTWRDMEPPLRETWNQVLQELVKRQQQEEEEQQGLVSGKKKSWVSIDLLGTEGKDIKKVNIWEPCEKWFAQVVWGVLWVLQIVLWGCLMWEVRKGNQCQAEEVIALVSDPGGFQRVQHVETVPVTCVTKNFTQWGCQPEGAYPDPELEYRNISREILEEVYKQDWPWNTYHWPLWQMENMRQWMKENEKEYKERTNKTKEDIDDLVAGRIRGRFCVPYPYALLRCEEWCWYPESINQETGHAEKIKINCTKAKAVSCTEKMPLAAVQRVYWEKEDEESMKFLNIKACNISLRCQDEGKSPGGCVQGYPIPKGAEIIPEAMKYLRGKKSRYGGIKDKNGELKLPLSVRVWVRMANLSGWVNGTPPYWSARINGSTGINGTRWYGVGTLHHLGYNISSNPEGGICNFTGELWIGGDRFPYYYKPSWNCSQNWTGHPVWHVFRYLDMTEHMTSRCIQRPKRHNITVGNGTITGNCSVTNWDGCNCTRSGNHLYNSTSGGLLVIICRQNSTITGIMGTNTNWTTMWNIYQNCSRCNNSSLDRTGSGTLGTVNNLKCSLPHRNESNKWTCKSQRDSYIAGRDFWGKVKAKYSCESNLGGLDSMMHQQMLLQRYQVIRVRAYTYGVVEMPQSYMEERGENRRSRRNLQRKKRGIGLVIVLAIMAIIAAAGAGLGVANAVQQSYTRTAVQSLANATAAQQEVLEASYAMVQHIAKGIRILEARVARVEALVDMMVYQELDCWHYQHYCVTSTRSEVANYVNWTRFKDNCTWQQWEEEIEQHEGNLSLLLREAALQVHIAQRDARRIPDAWKAIQEAFNWSSWFSWLKYIPWIIMGIVGLMCFRILMCVISMCLQAYKQVKQIRYTQVTVVIEAPVELEEKQKRNGDGTNGCASLEHERRTSHRSFIQIWRATWWAWKTSPWRHNWRTMPYITLLPILVIWQWMEENGWNGENQHKKKKERVDCQDREQMPTLENDYVEL
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: OPSD_LEOKE
Sequence: YLVSPAGYAALGAYMFLLILVGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVLGGFTTTMYTSMHGYFVLGRLGCNLEGFFVTLGGEIALWSLVVLAIERWIGVFKSIRNFRFTEDHAIMGLGFSWVMAATCAVPPLVGWLRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFIVHFLIPLIVIFFCYGRLLCAVKEAAAAQQESETTQRAEKEVSRMVVIMVIGYLVCWLPYASVAWWIFCNQGSEFGPIFMTLPAFFAKSPAIYNPLIYICMNKQFPHCMI
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: CC171_HUMAN
Sequence: MNLNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHSNLSIPSRAPLPADTTGIGDFLPLKAELDTTYTFLKETFINTVPHALTSSHSSPVTMSANANRPTQIGL
What are the official names of this protein?
Coiled-coil domain-containing protein 171.
Protein: GPM6A_HUMAN
Sequence: MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFEMARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNLWTICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTVSENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT
What is the function of this protein?
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells.  Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation.  GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways.  May be involved in neuronal NGF-dependent Ca(2+) influx.  May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
What are the official names of this protein?
Neuronal membrane glycoprotein M6-a, M6a.
What is the protein family that this protein belongs to?
Belongs to the myelin proteolipid protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell projection, dendritic spine. Cell projection, filopodium. Cell projection, neuron projection. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons (By similarity).