PharMolix/UniProtQA huggingface dataset:
Protein: SSRP_KLEP7
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEDEYEAGLALQGWEVKSLRAGKANIGDSYVILKDGEAFLFGANFTPMAVASTHYVCDPTRTRKLLLNQRELDTLYGRINREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRTDLKDREWALDKARIMKHAGR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PSBN_GUITH
Sequence: METATVLIIFIASLLLGLTGYSIYTAFGPNSKELRDPFDDHED
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NUOB_FRATO
Sequence: MGIGNENKGFITASADALINWVRTGSLWPVTTGLACCAVEMMHAGAARYDLDRFGIVFRPSPRQSDVLIVAGTLCNKMAPALRQVYDQMPDPKWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALVYGIIQLQNKIIRKDTIARK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PKDCC_HUMAN
Sequence: MRRRRAAVAAGFCASFLLGSVLNVLFAPGSEPPRPGQSPEPSPAPGPGRRGGRGELARQIRARYEEVQRYSRGGPGPGAGRPERRRLMDLAPGGPGLPRPRPPWARPLSDGAPGWPPAPGPGSPGPGPRLGCAALRNVSGAQYMGSGYTKAVYRVRLPGGAAVALKAVDFSGHDLGSCVREFGVRRGCYRLAAHKLLKEMVLLERLRHPNVLQLYGYCYQDSEDIPDTLTTITELGAPVEMIQLLQTSWEDRFRICLSLGRLLHHLAHSPLGSVTLLDFRPRQFVLVDGELKVTDLDDARVEETPCAGSTDCILEFPARNFTLPCSAQGWCEGMNEKRNLYNAYRFFFTYLLPHSAPPSLRPLLDSIVNATGELAWGVDETLAQLEKVLHLYRSGQYLQNSTASSSTEYQCIPDSTIPQEDYRCWPSYHHGSCLLSVFNLAEAVDVCESHAQCRAFVVTNQTTWTGRQLVFFKTGWSQVVPDPNKTTYVKASG
What is the function of this protein?
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages.  Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405).  Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405).  May also have serine/threonine protein kinase activity.  Required for longitudinal bone growth through regulation of chondrocyte differentiation.  May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).
What are the official names of this protein?
Extracellular tyrosine-protein kinase PKDCC, Protein kinase domain-containing protein, cytoplasmic, Protein kinase-like protein SgK493, Sugen kinase 493, Vertebrate lonesome kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Secreted. Golgi apparatus.
Protein: MET3_USTMA
Sequence: MANAPHGGVLKDLLVRDAPIAAQLRQEADTLPEIVLTERQLCDLELIINGGFSPLQGFMNQTDYNGCLDNMRLADGNLFPMPITLDVDEQQIEALKIQQGARIALRDPRDDNAIAIITVTDVYAVDKVREATAVFGSDDLAHPAITYLHKSVKNFYVGGDVQAVSKPAYYDYVALRYTPAELRQHFAKISWRKVVAFQTRNPMHRAHRELTVRAARQRQANVLIHPVVGMTKPGDVDHYTRVRVYQSLMPRYPNGMATLALLPLAMRMGGPREALWHAIIRKNFGVTHFIVGRDHAGPGKDSSGKDFYGPYDAQTLVTKYTEELGIEMVPFQQMTYIPSTDEYQPVDEVTPGTQTMDISGTELRRRLRTGAAIPDWFSYESVVKTLRESYPPKAKQGFTLFLTGLHNSGKDQIARALQVKLNEQGGRSVSLLLGETVRSELSSELGFSPDDRQKNIQRISFVAAELTRAGAAVIAAPIAPYEKSRATARDIITKTGGAGNFFLIHVATPLEYCEATDRKGNYAKARAGQIKGFTGVDDVYEEPTDADLVVDISRQSVAEITHSIILLLEAQSLI
What is the function of this protein?
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP.  Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the APS kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_LEUMM
Sequence: MSRIGNKTITLPADVTVSQEGAVVTVKGPKGELSREIVSAITMTVEGNEVSFSRDSDDSKTRALHGTTRANVANMVEGVSEGFTKTLKLVGVGYRAAKSGSKLTLSVGYSHPVDFEDREELSVEVPDALTIKVSGISKQKVGDLAAEIRAVRSPEPYKGKGIRYEGEVVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SPEB_ECO57
Sequence: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHNRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLAAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPNHSVQIGIRTEFDKDNGFTVLDACQVNDRSVDDVIAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: PPEP1_CLOD6
Sequence: MRPSKKLLIAIISIFLISSVPVSAHADSTTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKYLNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPKGWEGTGKTWDDVPGLGGSTVALRIGFSNKGKGHDAINLELHETAHAIDHIVLNDISKSAQFKQIFAKEGRSLGNVNYLGVYPEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK
What is the function of this protein?
Zinc-dependent endoprotease with a unique preference for proline residues surrounding the scissile bond.  Exhibits a high preference for an asparagine at the P2 position and hydrophobic residues (Val, Ile, Leu) at the P3 position.  Efficiently cleaves the LPXTG cell surface proteins CD630_28310 and CD630_32460 at multiple cleavage sites in vivo.  Has a role in the regulation of C. difficile adhesion versus motility by cleaving surface adhesion proteins such as the collagen binding protein CD630_28310, and is important for efficient infection.  Is also able to cleave fibronectin and fibrinogen in vitro; cleaves at the N-terminus of the beta-chain of fibrinogen.  Destabilizes the fibronectin network produced by human fibroblasts.  Therefore, may be important in key steps of clostridial pathogenesis by degrading extracellular matrix components associated with the gut epithelial cells.  To a lesser extent, IgA1, IgA2, and human HSP 90-beta, but not HSP 90-alpha, are also substrates for the enzyme.  Is not active on different collagen types, casein and gelatin.
What are the official names of this protein?
Pro-Pro endopeptidase, PPEP-1, Zinc metalloprotease Zmp1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M34 family. Pro-Pro endopeptidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MGR1_CANAL
Sequence: MGVYIPPPNDKDDGDKKKQDTNSNTNQPTPPSSSSPSGSTTIYIPNPASSIPRNPKVGLIWGPLTPASDNLPALYSMIGLQFVIGCGFFKYARTLSRLRPIGGFQQQPHAHMAPKLVRTGPIWKIALSVITGSALSFGSGLELCRVTLPYDPWYDEAQHYRRMAVKNGDKPSSWFGAYRYYKPMDFKTWIDKVGDWIENVEKEIKIDDPANFANLSLELGKNSNVINVQRQPQTSGGILNKLNNKGKYLEIYTKLNENNTKRWEKLLHEDLNEVTELNKAPRLDLILEGKSDLINPEFTKSAIILGNHTMDDDDQFEMVWLNFEPWDELKLDTEYDIRLVPSYAGATEEIENEDQESPLTDNVVAKQT
What is the function of this protein?
Component of the mitochondrial inner membrane i-AAA protease complex required for mitochondrial inner membrane protein turnover.
What are the official names of this protein?
Mitochondrial inner membrane i-AAA protease complex subunit MGR1.
What is the protein family that this protein belongs to?
Belongs to the MGR1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TSGA_YERPE
Sequence: MNNSNRIRLTWISYLSYALTGALVIVTGIVMGNIAEYFNLPIASMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLVFGFILMLIAIAGLMVGHNLMIFSISMFIFGVVSGITMSIGTFLVTHMYEGRQRGSRLLFTDSFFSMAGMIFPIAAAMLLARHIEWYWVYACIGLLYVGIFVLTLCSEFPVLGHKATDQSKPVVKEKWGVGVLFLAIAALCYILGQLGFIQWVPEYATKTFNMNISQAGQLVSNFWISYMIGMWIFSFILRFFDLQRIVTVLAAMATLAMYLFVSTDNPAYLSYYILALGFVSSAIYTTLITLGSLQTKVSSPKLVNFILTCGTVGTMLTFVVTGPIVANNGVHAALETANGLYLAVFILCLALGFFTKHRSHGHVTH
What are the official names of this protein?
Protein TsgA homolog.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TsgA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: THAL_ARATH
Sequence: MGKKGGTLKRSSKSTKTRKDIVEDQYDDEIDAFHKQRDIVPLDVNDDTDESDEDDVQPVFDLQGVDDESEEDEDTEDEEEAENGLTAKMIRQKKYLRAKFGDGDDEMADDDKDKEEDKRSTWGGRSGLYHSGDNVDFDILSSDDEDIKAEEEEVIRLRAEQLGSITAADAGLDDDSEEDSDRELTMEEISDKGKQATKSITDKKEKGDKDTHVEEIKKDINSLSKEEQMDVVYSSAPEIVGLLSELNDAVEELESKINPVMNKLKEGEISLNGLARYLEVKQLLLLTYCQSITFYLLLKSEGQPIRDHPVLARLVEIKSLLDKIKELDEELPPGFEESLARSIANGAVQKVVKEDQLTSPVSDSVDRITQDTAKPMKIDNAREEKKKKGEKRKHQNDLVDVQSEEMLKLRAALEGKLRTNGVLGSTVSKSDKAQKRQKLANRKLETFDDYVDDADNSTHNVTADKLTKLVSTKRKPKTISGDDDLPQRDDIGERRRKFELRVLAGAGVKSSEGDGRNKNGAFASDDEDDNDGDNNDMVDNDGESEDEFYKQVKQKQQAKRAAKAEIYSRKPHLMPSSPEHVDGKRHISNQMVSNRGLTRQRNRDLKNPRKKYRKNYEKKVTRRKGQVRDIRKQTGPYAGEARGINPNTSRSIRM
What is the function of this protein?
Essential protein during embryogenesis (PubMed:15266054, PubMed:27792779).  Involved both in gene transcription regulation and in processing events critical for proper rRNA biogenesis and nucleolar organization during reproduction; contributes to pre-rRNA processing at the 5' external transcribed spacer (PubMed:27792779).  Binds RNA (By similarity).
What are the official names of this protein?
Protein THALLO, Protein EMBRYO DEFECTIVE 2777.
What is the protein family that this protein belongs to?
Belongs to the SAS10 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.
Protein: RL9_FRACC
Sequence: MKLILTQEVPGLGSPGDIVEVANGYGRNYLVPRRYAILATKGAERQVEQIKRARSARAVRDLGHAQEIAGQLGGLKVELTSRAGKEGRLFGSVTAADVVEAVTAAGGPELDRRRVELTTPIKSLGAYTVAVHLHPEVTATVKLQVTQA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: SYD_XYLFA
Sequence: MRTHFCGLIDETLIGHTVTLAGWTDVARNLGGVCFIDLRDHEGIVQVTVDSRAIDQNNSELFKVASGLSYEDVLQVEGVVCARHAVNDKIKTGKVEVIATKIKILNKAAPLPFHAHENPGEDIRLKYRYLDLRRPEMQRMQRTRIKLVQALRRHLDMHGFQDIETPILTKATPEGARDFLVPARMHPGEFYALPQSPQLFKQILMVAGFDRYYQIARCFRDEALRADRQLEFTQLDMEFAFVSERDVQDFVEEMIRRVFKEVAGIELDTTFPRMTWTEAMRRFGSDKPDLRINLELIDVAALVADSTFTPFTDAVAHPNGRVAALRIPSGAVLSRKQIDEYAAYTAKYGATGLAYAKLAPIGEITSPIAKFFSEDAFAALLSHIGAEKGDIVFFGAGNYNKVSDFMGALRLKAGKDFALITADWRPLWVTDFPMFEWDEEAQRYVALHHPFTAPAAIDDIDELRAHARTALSRGYDMVLNGNEIGGGSIRIHRPEMQRAVFELLGITEDEARAKFGFLLDALNYGAPPHGGIAFGIDRIAALIAGTESIRDVIPFPKTTGAQCLMTDAPSSISEEQLSEIHVITKKPTP
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCYA_ENTDO
Sequence: EGNEYLVRKNVERLSLSEMNSLIHAFRRMQKDKSSDGFEAIASFHALPPLCPSPTAKHRHACCLHGMATFPHWHRLYVVQFEQALHRHGATVGVPYWDWTRPISKIPDFIASEKYSDPFTKIEVYNPFNHGHISFISEDTTTKREVSEYLFEHPVLGKQTWLFDNIALALEQTDYCDFEIQLEIVHNAIHSWIGGKEEHSLNHLHYAAYDPIFYLHHSNVDRLWVIWQELQKLRGLNAYESHCALELMKVPLKPFSFGAPYNLNDLTTKLSKPEDMFRYKDNFHYEYDILDINSMSINQIESSYIRHQKDHDRVFAGFLLSGFGSSAYATFEICIEGGECHEGSHFAVLGGSTEMPWAFDRLYKIEITDVLSDMHLAFDSAFTIKTKIVAQNGTELPASILPEATVIRIPPSKQDADIDIPLNHIRRNVESLDERDIQNLMAALTRVKKDESDHGFQTIASYHGSTLCPSPEEPKYACCLHGMPVFPHWHRVYLLHFEDSMRRHGSSVATPYWDWTQPGTKLPRLLADSDYYDAWTDNVTENPFLRGYITSEDTYTVRDVKPELFEIGGGEGSTLYQQVLLMLEQEDYCDFEVQFEVVHNSIHYLVGGHQKYAMSSLVYSSFDPIFYVHHSMVDRLWAIWQALQEHRHLPFDKAYCALEQLSFPMKPFVWESNPNLHTRAASTPQHLFDYNKLGYKYDDLEFHGMNIDQLENAIHKTQNKDRVFASFLLFGIKTSADVHLKLCKDETCEDAGVVFVLGGDNEMPWPFDRTYKMDITNVLHKMHIPLEDLYVHGSTIHLEVKIESVDGKVLDSSSLPVPSMIYVPAKEFTKEIEKEAVRGTIIRKNVNSLTPSDIKELRDAMAKVQADTSDNGYQKIASYHGIPLSCHYENGTAYACCQHGMVTFPNWHRLLTKQMEDALVAKGSHVGIPYWDWTTTFANLPVLVTEEKDNSFHHAHIDVANTDTTRSPRAQLFDDPEKGDKSFFYRQIALALEQTDFCDFEIQFEIGHNAIHSWVGGSSPYGMSTLHYTSYDPLFYLHHSNTDRIWSVWQALQKYRGLPYNTANCEINKLVKPLKPFNLDTNPNAVTKAHSTGATSFDYHKLGYDYDNLNFHGMTIPELEEHLKEIQHEDRVFAGFLLRTIGQSADVNFDVCTKDGECTFGGTFCILGGEHEMFWAFDRPFKYDITTSLKHLRLDAHDDFDIKVTIKGIDGHVLSNKYLSPPTVFLAPAKTTH
What is the function of this protein?
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
What are the official names of this protein?
Hemocyanin A-type, units Ode to Odg.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family. Hemocyanin subfamily.
Protein: MUTS_STRP6
Sequence: MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLIELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTSVRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQALVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFIERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFDSPCVDKLVNDIDSLPELEYLIRTAIDPDAPATISEGSIIRTGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTTSNLSLVPEHFFRKATLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKILATVDVLQSLAVVAETNHYIRPQFNDNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDAIFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHELTDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIMSVPPQVESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: O1628_CONCL
Sequence: MKLTCVLIVAVLILTACQVIAADEATNRATKRGCLMCWGSNVRCCEKANACVSINYECPKARR
What is the function of this protein?
Probable neurotoxin.
What are the official names of this protein?
Conotoxin Cal6.28, O1_cal6.28.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRI_THEON
Sequence: MAELKVTAIKEGTVIDHIPAGKGLKVIEILHLSRPNGGVLLLASNVHSKKLGKKDIVKIEGKFLSEEEVNKISLIAPTATVNIVRDYGVAEKFNVEIPDEIVGILRCANPNCVSNHEYVTSKFYVVSREPLKVRCHYCERTMEESEILSNL
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: RUVB_MYCBP
Sequence: MTERSDRDVSPALTVGEGDIDVSLRPRSLREFIGQPRVREQLQLVIEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELGSSLRVTSGPALERAGDLAAMLSNLVEHDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPAELERVLARSAGILGIELGADAGAEIARRSRGTPRIANRLLRRVRDFAEVRADGVITRDVAKAALEVYDVDELGLDRLDRAVLSALTRSFGGGPVGVSTLAVAVGEEAATVEEVCEPFLVRAGMVARTPRGRVATALAWTHLGMTPPVGASQPGLFE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RL23_BURM7
Sequence: MSEIRKNDHRLMQVLLAPVISEKATLVADKNEQVVFEVAPDATKQEVKAAVELLFKVEVDSVNVLVQKGKQKRFGRSMGRRKDVKKAYVCLKPGQEINFEAEAK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: TLCOF_ALOMR
Sequence: GDEEDEVEETLPVAEEGREKSCTTWRNSCMHNDKGCCFPWSCVCWSQTVSRNSSRKEKKCQCRLW
What is the function of this protein?
Modulates P-type voltage-gated calcium channels (Cav2. 1/CACNA1A) in rat cerebellar Purkinje cells and hippocampal CA1-CA3 neurons.  At saturating concentrations (>10 nM) the toxin decelerates activation kinetics and slightly increases peak amplitude without affecting deactivation kinetics (By similarity).
What are the official names of this protein?
Omega-lycotoxin-Gsp2671f, Omega-LCTX-Gsp2671f, Omega-Lsp-IA-like 5.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin (omega-lctx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MIAB_CALS4
Sequence: MRNSYYVSEEELKKQREIMEEIAWENRGKEVYYHIETYGCQMNVHDSEKLAGMLEEMGYKYTEDLEKADVLLFNTCAVREHAEVRVLGRVSQIKELKNRNPNLIIGISGCMMQEKHIVEAIREKYPHVDIVFGTHNIYKFPELLWQALNSRVQVIDVIENTQNVIEGLPIRRDSNLKAWVNIIYGCNNFCTYCIVPYTRGREKSRRPEDIIAEVKELAEKGYKEITLLGQNVNSYGKDLGGDINFAKLLYMLNDIKGIERIRFMTSHPKDISDELIYAMRDLDKVCEHLHLPVQAGSNKILKRMNRRYTREHYLEIIDKVRANIPDIAITTDIIVGFPGETEEDFFQTLDLVERVRFDGAYTFMYSKRAGTPAASMPDQVDDEVKKDRLIRLIELQNKISLEKSAELKGKVVEVLIEGVSKRDPNKLTSRTRTNKVVHFIGDESLIGKLANVKITETKAWTMQGELVEVLR
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCRB_LISW6
Sequence: MKHLFKLDPAKNLPHNSVTRLIHSGTDGFIIGGTDNLQTEAVENLYELLAETDLPIFLEVSDESMILPEAEHFLIPVVLNTENSKWTHGLHKELIKEMGEFIPWKRVTSEGYVILNKDAKVAQLTEAKTDLTEEDIIAYARLAENIFRLPIFYIEYSGMYGNPEVAKKVSAALDDTKFWYGGGIRSKEQAAEMAEYADTIIVGNIIYEDIEKALETTTVFAKKTV
What is the function of this protein?
Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP).  This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.
What are the official names of this protein?
Heptaprenylglyceryl phosphate synthase, HepGP synthase, Glycerol-1-phosphate heptaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
Protein: TRPV6_HUMAN
Sequence: MGPLQGDGGPALGGADVAPRLSPVRVWPRPQAPKEPALHPMGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDKDSVEKLELGCPFSPHLSLPMPSVSRSTSRSSANWERLRQGTLRRDLRGIINRGLEDGESWEYQI
What is the function of this protein?
Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124, PubMed:15184369, PubMed:23612980, PubMed:29258289).  Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity).  The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369).  Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation.  In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner.  Heteromeric assembly with TRPV5 seems to modify channel properties.  TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
What are the official names of this protein?
Transient receptor potential cation channel subfamily V member 6, TrpV6, CaT-like, CaT-L, Calcium transport protein 1, CaT1, Epithelial calcium channel 2, ECaC2.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.