PharMolix/UniProtQA huggingface dataset:
Protein: STXA_SYNVE
Sequence: MSSDLVMPALGRPFTLGMLYDTRREKLIPGFSLFGDETLQQYQSSNTQRSSEFKIVASDSTESKSSAMDIEASLGVSFLGGLVEVGGSAKYLNNTKKYQNQSRVTLKYKATTIYKQFTAPPGTVKVQETVITQRGLATHVVTGILYGANAFFVFDSDKVEDTNLQDIQGKMEAVIKKIPTISIEGSASVQLTDEEKSLASNLSCKFHGDFLLESLPTTFEDAVTTYQTLPTLLGEDGASAVPMKVWLVPLKKFFSKAKLLTQEITVSKVRRIHTTLEELYKLKRRANEAMDDKLVQQIPLIHDKISNFHQIFQDYMLTVQKKIAEKLPLVRAGTESEQSLQKIIDDRAKSPFSNENVSTWLEVIEREIAVLKSCAGMVEGTQAKFVSNQTELDREVLAEDVKHALCFVFTSVERNDPYLKVLSDYLESPDSKDGKEAVPSTEDKWCFSTRVVLKMKQRAQTFCDHVNDFEKSRNVGFFVTALENGKFQGASIYHYKDGSLATQDFTFPRMPFVQGYKKRSDLLWYACDLTFDRNTINIWVSLSDNDTFAASEHGKRQNYPKHPERFLCYNQVLCNEGLTGKHYWEVEWNGYVDVGVAYISISRKEDNWVSAIGHNTCSWVFSSIPRAGYVERYNQRQYYVTVPTPGFKQLGVFLNWPDGSLSFYAVSSDEVHHLHTFKTKFTEPVYPAFCLGYRFDHGTVRLL
What is the function of this protein?
Has hemolytic and lethal activities.  Its hemolytic activity is inhibited by anionic lipids, especially potently by cardiolipin.
What are the official names of this protein?
Neoverrucotoxin subunit alpha, NeoVTX subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the SNTX/VTX toxin family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into the venom gland lumen. The secretion is proved by the fact that the complete sequence showed below is found in the venom gland's lumen, although no signal peptide has been found. This protein may follow a novel secretion pathway. It has been reported that venom- secreting cells of stonefishes do not possess Golgi apparatus and rough endoplasmic reticulum.
Protein: FUCI_STRPS
Sequence: MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLKYPDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIPHAIWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEANDTDIPEDVKEKLLRYARAALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRGIYDPEEFERAMVWVKEHIKEGVDRNREDLILSKEEKEKQWEFVIKMFMIGRDLMVGNPRLAELGFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFATENDSLNGVSMLFNYLLTNTPQIFADVRTYWSPEAVERVTGYTLEGRAAAGFLHLINSGSCTLDGTGQATRDGKPVMKPFWELDESEVQAMLENTDFPPANREYFRGGGFSTRFLTKGDMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPTTWFAPRLTGKGAFKSVYDVMNNWGANHGAITYGHIGADLITLASMLRIPVNMHNVPEEDIFRPKNWSLFGTEDLESADYRACQLLGPLHK
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
What are the official names of this protein?
L-fucose isomerase, 6-deoxy-L-galactose isomerase, FucIase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCHS_MORMO
Sequence: MTLSINDQNKLDAFWAYCVKNQYFNIGYPESADFDYTNLERFLRFSINNCGDWGEYCNYLLNSFDFEKEVMEYFADLFKIPFEQSWGYVTNGGTEGNMFGCYLGREIFPDGTLYYSKDTHYSVAKIVKLLRIKSQVVESQPNGEIDYDDLMKKIADDKEAHPIIFANIGTTVRGAIDDIAEIQKRLKAAGIKREDYYLHADAALSGMILPFVDDAQPFTFADGIDSIGVSGHKMIGSPIPCGIVVAKKENVDRISVEIDYISAHDKTITGSRNGHTPLMLWEAIRSHSTEEWKRRITRSLDMAQYAVDRMQKAGINAWRNKNSITVVFPCPSERVWREHCLATSGDVAHLITTAHHLDTVQIDKLIDDVIADFNLHAA
What are the official names of this protein?
Histidine decarboxylase, HDC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: GUNB_GLOTR
Sequence: GVQISQISSFPTTADVSYDFNITNALGGIQPVGSLK
What is the function of this protein?
Has carboxymethylcellulase activity.
What are the official names of this protein?
Endoglucanase Cel12A, Cellulase, Endo-1,4-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 12 (cellulase H) family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: FAC19_MYCS2
Sequence: MALNIADLAEHAIDAVPDRVALISGGDQLTYGQLEEKANRFAHYLIDQGVKKDDKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELKYLFENSDMVALVHERRYSDRVANVLPETPDIKTILVVEDGSDDDYERFGGVEFYSALEKSSPERDFGPRSEDDIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGEPIEDEYGLAKQAAANPPMVRYPIPPMIHGATQSATWMALFAGGTVLLTPEFNPDEVWQAIHDHKVNLLFFTGDAMARPLLDSLLAAKDAGKEYDLSSLFLLASTAALFSTSLKEKFLELLPNRVITDSIGSSETGFGGTSIVAKGQSHTGGPRVTIDKNTVVLDDDGNEVKPGSGVRGVIAKRGHIPLGYYKDEKKTAETFKTINGVRYAIPGDYAEVEADGSVTMLGRGSVSINSGGEKIYPEEVEAALKGHPDVFDALVVGVPDPRFGQHVAAVVHPREGTRPTLAELDAHVRTEIAGYKVPRSLWLVDEIKRSPAGKPDYRWAKDVTEERPADEVHANHVAANAK
What is the function of this protein?
Plays an essential role in degradation of the side chains of C-24 branched-chain sterols.  Not essential for degradation of straight chain sterols such as cholesterol (PubMed:27164074).  Catalyzes the activation of medium/long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.  May be involved in the degradation of cholesterol via the degradation of the side chains of C-24 branched-chain sterols (By similarity).
What are the official names of this protein?
Medium/long-chain-fatty-acid--CoA/3-oxocholest-4-en-26-oate--CoA ligase, FACL, Acyl-CoA synthetase, FACL19, Steroid-CoA ligase, Steroid-coenzyme A ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: PYRE_PSEAB
Sequence: MQAYQRDFIRFAIERGVLRFGEFTLKSGRTSPYFFNAGLFDSGLALARLGRFYAEAVIDSGIDFDVLFGPAYKGIPLAATTAVALAEQHQRDLPWCFNRKEAKDHGEGGTLVGAPLSGRVLIIDDVITAGTAIREVMQIIDAQGARAAGVLIALNRQERGKGELSAIQEVERDFGMPVVSIVSLEQVLEYLAEDAELKKHLPAVEAYRAQYGI
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: ARHG2_PIG
Sequence: MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTTRERPSSAIYPSDSFRQSLLGSRRGRSPLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEGAEVIYNELMSDFEMGEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSPRNFVIHRLGDLLITQFSGPSADQMRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKVTRSAVLKRHGVQECILLVTQRITKYPVLISRILQHTHGIEEERQDLTTALGLVKELLSNVDQDVHELEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTAAGRFKDVLMLLMTDVLVFLQEKDQKYIFPALDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQSVRVCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLQEKVGLFAEMTHFQVEEDGGGGMPLPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTSREPALPVETDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQKDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLTRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREVEEARRQLAALGHTEPLPAEAPWARRPLDPRRRSLPAGDALYLSFTPPQPSRGHDRLDLPVTIRSVHRPFEDRERQELGSPDERLQDSSDPDTGSEEEGSSSRLSPPHSPRDFTRMQDIPEETESRDGEPVASES
What is the function of this protein?
Activates Rho-GTPases by promoting the exchange of GDP for GTP.  May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer.  Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases.  May stimulate instead the cortical activity of Rac.  Inactive toward CDC42, TC10, or Ras-GTPases.  Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens.  Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase.  Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.  Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability.  Involved in neuronal progenitor cell division and differentiation.  Involved in the migration of precerebellar neurons.
What are the official names of this protein?
Rho guanine nucleotide exchange factor 2, Guanine nucleotide exchange factor H1, GEF-H1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization. Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton.
Protein: RL13_MYCA9
Sequence: MPTYTPKAGDVTRTWYVIDATDVVLGRLAVQAANLLRGKHKPTFAPHVDGGDFVIIINAEKIALSGNKLTNKFAYRHSGFPGGLSKRSIGEQLEKFPTRTVEKAIVGMLPKNKLGRQIERKLKVYAGAEHPHAAQQPIPFEIKQVAQ
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: DOK2_MOUSE
Sequence: MVRMEEPAVKQGFLHLQQQQTFGKKWRRFAAVLYGESGCALARLELQDVPEKTRRGEATRKVVRLSDCLRVAEVGSEASSPRDTSAFILETKERLYLLAAPSAERSDWIQAICLLAFPGQRKGSPGLEEKSGSPCMEENELYSSSTTGLCKEYMVTIRPTEASERCRLRGSYTLRTGVSALELWGGPEPGTQLYDWPYRFLRRFGRDKATFSFEAGRRCLSGEGNFEFETRHGNEIFQALEKVIAVQKNATPSGPPSLPATGPMMPTVLPRPESPYSRPHDSLPSPSPGTLVPGMRPGAPEGEYAVPFDTVAHSLRKSFRGLLTGPPPHLPDPLYDSIQEDPGAPLPDHIYDEPEGVAALSLYDRTQRPSGETWREQATADGGPSSLQQDSSVPDWPQATEYDNVILKKGPK
What is the function of this protein?
DOK proteins are enzymatically inert adaptor or scaffolding proteins.  They provide a docking platform for the assembly of multimolecular signaling complexes.  DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3.  May be involved in modulating Bcr-Abl signaling.  Attenuates EGF-stimulated MAP kinase activation.
What are the official names of this protein?
Docking protein 2, Dok-related protein, Dok-R, Downstream of tyrosine kinase 2, IL-four receptor-interacting protein, FRIP, p56(dok-2).
What is the protein family that this protein belongs to?
Belongs to the DOK family. Type A subfamily.
Protein: C1436_CAMJE
Sequence: MLIKLNDYEKNITQKIKDLKNASGSHSPSIFTMAEQIPELNIKIDSCFLSNPYATALFLRYLKEELIDGQKLRSVLEFYPSQNSIIAKTVADFIGIDPKNVFIGNGAIEIIQAVMHNFVGKKIIVNIPTFSSYYEFAKSETNVVYYQLSKEDNYNLNIEHYLNFVKNENPDSVVLINPNNPDGGYINYEKLRYILSELKYVKNIIIDESFIHFAYENKDYNGINIEYLFKEFHNTIIIKSMSKDFGVAGIRIGYAIMSEDKIRGLLKNGYLWNSSGLSEYFLRLYVRKNFFDEYDKVRREYIQETQTFFRKLSGIKQFKVYPSMANFALVELLDGSSSTDFVAKMLIKYGIYMRTCNDKIGLEGEFIRIASRTLEENDMVLKSICDVFKE
What is the function of this protein?
Pyridoxal phosphate (PLP)-dependent decarboxylase involved in the biosynthesis of amidated D-glucuronic acid structures found on the capsular polysaccharide (CPS) of C. jejuni.  Catalyzes the decarboxylation of L-serine phosphate to ethanolamine phosphate.  Less active with L-threonine phosphate.  No activity with L-serine, L-threonine, L-aspartate or L-glutamate.
What are the official names of this protein?
L-serine phosphate decarboxylase Cj1436c, Capsule polysaccharide biosynthesis protein Cj1436c, PLP-dependent decarboxylase Cj1436.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: RIBBA_STAHJ
Sequence: MEFDEIKDALNALKRGESIIVVDDEDRENEGDLVAITQWMNDNTINFMAKEGRGLICAPISKDLALKFNLMPMVEHNTDGFGTNFTVSIDHATTSTGISAFDRMATARALINPESTPEDFHKPGHLFPLIAKENGVLERTGHTEAAVDLAKLTKAAPAGVICEIMNEDGTMAKGEQLEAFKHQHGLKMITIESLVNYQKDKDTSVELKAKVNMPTDHGAFEMYGFESSLTKEEIVVLAKGEPRVTENVRIHSACLTGDIFHSQRCDCGAQLESAMKYINEHGGMIIYLPQEGRGIGLINKLRAYELIEQGHDTVTANLALGFDEDLRDYHIAAQILNYFNVQQVNLLSNNPKKFEGLSEYGIKVADRTPIIVAENEHNHDYMNTKKIKMGHLI
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: PTH_LEPCP
Sequence: MIRLFVGLGNPGPEYEATRHNAGFWWTDALARRWNCQLQPDRSYHGLMARCTQRGTPVWLLQPMTYMNLSGKSVAALARFFKIEPAEILVVHDELDLLPGQMKLKQGGSAAGHNGLKDIQAQLGNPEFWRLRLGIGHPGVKAEVAAYVLRKPPSAEREAIEACIDRSLDAVDRMLGADMPAAMMQMHAKPPRPKPPRPVTAPGAPVPPTEPSA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: V220_FOWPN
Sequence: MIYTEFTILYKSSLPKYLRIMYFTSIGIFFHKLSIVSLEIVSSKTVNDLEIKLSLSFAVYTAFIIISLYMINSGNVTLLYNLSNIFDSILFRYISNRLLLPIFTSSIFNISFSHSNL
What are the official names of this protein?
Uncharacterized protein FPV220.
Protein: RNH2_RHOE4
Sequence: MSSWPPRVVIRRSAGLRTMESALARTGLGPVAGVDEAGRGACAGPLVIAACVLAPKPQAALARLDDSKKLTERAREELFPAIKRLALAWSVVSVPAAEVDQIGIHVANIEGMRRAVAGLDLEPGYVLTDGFRVPGLTAPSLPVIGGDGAAACIAAASVLAKVTRDRVMTEMDETHPGYGFAIHKGYSTPLHMDALDELGPCPEHRMTYANVVAAGVRLEQRAGRTG
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HN522_CYRHA
Sequence: CNGRDVPCDPDPAKNRRCCSGLECLKPYLHGTWYQDYCYYVEK
What is the function of this protein?
Probable ion channel inhibitor.
What are the official names of this protein?
Hainantoxin F5-22.36, Peptide F5-22.36.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 14 (magi-1) family. 02 (HWTX-XVIc) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DBP10_DEBHA
Sequence: MSDEEDYDIAGTLALAGSDSEPESDLNSDNEEVQDEIVSDEDDTKHKPNKKQKLEKGKSKQTFPSLELSDDEAENESKDMASYFVANNPQAKKAKNGSFPSFGFSKFLLTNISKKGFKQPTPIQRKTIPLIMENRDVVGMARTGSGKTAAFTLPLVEKLKSHSPRVGVRAIILSPSRELASQTFKQVKEFSKGTDLRSIVLIGGDSLEEQFSSMMTNPDVIVATPGRFLHLKVEMELELKTVEYIVFDEADRLFEMGFAEQLNELIAALPSSRQSLLFSATLPRSLIDFAKAGLTNPVLVRLDAETKISDQLQMAFFSIKNNEREASLLYVLQEVIKLPLASPEEVKRYSDMEKRDNGSEDEAEDENNNKKKRFKFKKERLPPANMLPSKHSTIIFVPTKHHVEYVTTLLKDAGYLVSYIYGTLDQHARKQQLYQFRIGMTSLLVVTDVAARGIDIPILANVVNYTLPGSSKIFIHRVGRTARAGNSGWAYSIVNEKELPYLLDLELFLGRKVLLTSMHEKKCEMLKTKQSSNYVEPKVSYTDRLVLGSIPRVDIETFQELYENILRNHYELSVVKGVATKGEKLYYRTRQSASQESLKRSKEILSTGNWDDQHLLFGPNLEKEKEKFLTQLLNRKSKETVFEFNKKGNDRDEDSLVEFMHKRRKQIAPIQRRAKEKRELLEKERMAGLTHGIENEILKNDGEIGYSGITIEADEEELQDAFEDADELIEKKKIEKKKSFRDPQYFLSHYAPAAVIQDQQLSLSSSFANDAAKATFDLDNDEKLNANKQVMQWDRKKGNYVNAHSTDKKFIIGESGQKIPATYRSGRFDDWKKQRNLKPTKTGAMEANATNGNDRRFKHKKVASPKLPDKFRDDYHKQKEKVKKAVDSGLKVKGYNKPGQKQELRSTEDIRKAREAKDKKKQKNARPSRKRK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP10.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: BIOF_PARL1
Sequence: METLDGFAREKLDALEAQALRRRLVETDRREGAIAFREGRRLVSFCCNDYLNLSQHPDVKRAAVEATGKYGTGSGASRLVSGNHPLFGELERRLADWKQTEDCVVFGSGYMANMGIIPSLVREGDLIIADELSHACLLSGSKLSGARVAIFRHNDIAHLEELLGAHRGGAKHCLILTDGIFSMDGDAAPVEALAALAAQHDAWLMTDDAHGIGVVGHEGRGSSFMGERKAAVPLQMGTLSKAVGGYGGYLCASAPVVDLIRTRARTLIYSTGLPPAAVAASIAALDFIRGNPDYCKRPVEKARSFTRALGLADPVSPIVPLILGDAEVTLAASALLEAEGYLVTGIRPPTVPEGTARLRFTFTAEHDDADIARLATLVRERIIQRRAAE
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: KASH5_BOVIN
Sequence: MDMPEDQAGGPTAKMYLWDQAEDRSLGTLLSLEEQILNSTFEACDPQRTGTVAVTHLLAYLEAVTGRGPQDARLQTLACSLDPSGEGPQATVDLDTFLVVMRDWITACQLDGGLELEEETAFEGALTSQQLPSGCPEVEDPANLESFGGEDPRPELPATADLLSSLEDLELSNRRLAGENAKLQRSVETAEEGSARLGEEISALRKQLRSTQQALQLARGVDEELEDLKTLAKSLEEQNRSLLAQARHTEKEQQRLVAEMETLQEENGKLLAERDGVKRRSEELASEKDILKRQLYECEHLICQRDAILSERTRHAESLTKTLEEYRATTQELRLEISHLEEQLSQTQEGLDELSEGAQVRRVDCTNLLPPSLGVELQAIQQRNLQEESAHPQEGREEPSTRLPRREEEDGAEIQVMVDLPLHPEDSHPGDILGNPPESSPSEPELQQALVPMVKELVPVRRPVWGQLCLWPLHLRRLRVTRHLLIPAPLLGLLLLLLLSVLLLGQSPPPTWPHLQLCYLQPPPV
What is the function of this protein?
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton.  The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.  Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly.  Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes.  Essential for male and female gametogenesis.  Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes.  In oocytes is involved in meiotic resumption and spindle formation.
What are the official names of this protein?
Protein KASH5, Coiled-coil domain-containing protein 155.
What are the subcellular locations of this protein?
Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus. Chromosome, telomere. Note=Localized exclusively at telomeres from the leptotene to diplotene stages. Colocalizes with SUN2 at sites of telomere attachment in meiocytes. At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles.
Protein: 3SO8_NAJAT
Sequence: MKTLLLTLVVVTMVCMDLGYTTICYNHLSRTPETTEICPDSWYFCYKISLADGNDVRIKRGCTFTCPELRPTGKYVYCCRRDKCNQ
What is the function of this protein?
Antagonist of muscle and neuronal nicotinic acetylcholine receptors (nAChR) with highest affinity for neuronal alpha-7/CHRNA7 nAChRs.
What are the official names of this protein?
Neurotoxin homolog NL1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group VIII (haditoxin) sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HIF1A_BOSMU
Sequence: MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKKGGYVWIETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSSNEKLQNINLAMSPLPASETPKPLRSSADPALNQEVALKLEPNPESLGLSFTMPQIQDQPASPSDGSTRQSSPEPNSPSEYCFDVDGDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLENSSTSPQSASTNTVFQPTQMQEPPIATVTTTATSDELKTVTKDGMKDIKILIAFPSPPHVPKEPPCATTSPYSDTGSRTASPSRAGKGVIEQTEKSHPRSPNVLSVALSQRTTAPEEELNPKILALQNAQRKRKIEHDGSLFQAVGIGTLLQQPDDRATTTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLVCRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
What is the function of this protein?
Functions as a master transcriptional regulator of the adaptive response to hypoxia.  Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.  Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (By similarity).  Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity).  Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300.  Activity is enhanced by interaction with NCOA1 and/or NCOA2.  Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP.  Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity).
What are the official names of this protein?
Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (By similarity).
Protein: RL10_THESM
Sequence: MAHVAEWKKKEVEELTKLLQDYPVIALVDVADVPAYPLSKMRESLRDKAVLRVSRNTLIELALKKAAQELNDSNLEKLIEHIQGGTGILVTKINPFKLYKFLEESKKPAPAKAGAPAPRDVVVPAGPTPLSPGPLVGEMQALGIPARIEKGKVSIQKDTVVLKAGEIITPQLANILNQLGIEPLEVGLKLLAAYEHGIVYTPEVLAIDEEQYISMLQQAYMHAFNLSVNVAYPTKQTIEAIIQKAFLGAKNVAVEAGYITKESAGDILGKAFRIALLIAQELPEELLDEKTKELLNQQAQVIAAQPQPAEEAEEKVEEEEEEEKEEEEALAGLGALFG
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10, Acidic ribosomal protein P0 homolog.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: GRM4_HUMAN
Sequence: MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
What is the function of this protein?
G-protein coupled receptor for glutamate.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.  Signaling inhibits adenylate cyclase activity.
What are the official names of this protein?
Metabotropic glutamate receptor 4, mGluR4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
Protein: DAPB_RHIML
Sequence: MSQMRLVVVGAAGRMGRTLIKAIAENPGCMLSGAVERPGSAAVGQDAGFVAGMASCGVLVTDEPGSAFAEADGVLDFTTPDATAEYSSLAAQVGIVHVVGTTGMEPVHFSKLVRAARTIPVVQSGNMSLGVNILAALVQKVAAILDKEWDIEVLEMHHRMKVDAPSGAALLLGEAAASGRQTILSDHYVAGRDGYTGCRTVGTIGFAPCAGXVVGDHKVVFAGAGXRIELSHIAEDRSLFAQ
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.