PharMolix/UniProtQA huggingface dataset:
Protein: ATP8_ONCMY
Sequence: MPQLNPAPWFAILVFSWLVFLTVIPPKVLGHTFTNEPTSQSTEKAKPEPWNWPWH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: ATG8_PENRW
Sequence: MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGDL
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Participates also in membrane fusion events that take place in the early secretory pathway.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
What are the official names of this protein?
Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier atg8.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor.
Protein: DPOL_BPT5
Sequence: MKIAVVDKALNNTRYDKHFQLYGEEVDVFHMCNEKLSGRLLKKHITIGTPENPFDPNDYDFVILVGAEPFLYFAGKKGIGDYTGKRVEYNGYANWIASISPAQLHFKPEMKPVFDATVENIHDIINGREKIAKAGDYRPITDPDEAEEYIKMVYNMVIGPVAFDSETSALYCRDGYLLGVSISHQEYQGVYIDSDCLTEVAVYYLQKILDSENHTIVFHNLKFDMHFYKYHLGLTFDKAHKERRLHDTMLQHYVLDERRGTHGLKSLAMKYTDMGDYDFELDKFKDDYCKAHKIKKEDFTYDLIPFDIMWPYAAKDTDATIRLHNFFLPKIEKNEKLCSLYYDVLMPGCVFLQRVEDRGVPISIDRLKEAQYQLTHNLNKAREKLYTYPEVKQLEQDQNEAFNPNSVKQLRVLLFDYVGLTPTGKLTDTGADSTDAEALNELATQHPIAKTLLEIRKLTKLISTYVEKILLSIDADGCIRTGFHEHMTTSGRLSSSGKLNLQQLPRDESIIKGCVVAPPGYRVIAWDLTTAEVYYAAVLSGDRNMQQVFINMRNEPDKYPDFHSNIAHMVFKLQCEPRDVKKLFPALRQAAKAITFGILYGSGPAKVAHSVNEALLEQAAKTGEPFVECTVADAKEYIETYFGQFPQLKRWIDKCHDQIKNHGFIYSHFGRKRRLHNIHSEDRGVQGEEIRSGFNAIIQSASSDSLLLGAVDADNEIISLGLEQEMKIVMLVHDSVVAIVREDLIDQYNEILIRNIQKDRGISIPGCPIGIDSDSEAGGSRDYSCGKMKKQHPSIACIDDDEYTRYVKGVLLDAEFEYKKLAAMDKEHPDHSKYKDDKFIAVCKDLDNVKRILGA
What is the function of this protein?
Replicates the viral genomic DNA.  This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'-5' direction for proofreading purpose.  The DNA synthesis very likely occurs by strand displacement.
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-A family.
Protein: COQ7_SCHPO
Sequence: MLSRRQLIPIATKSVSPFLRSSITCRRISMGRKELSEKDSNILDSVIRVDQAGELGANQIYKGQHFILQFTDPKVAPTIQHMWDQEKYHLATFDNYVLKNRVRPTFLRPFWDIAGFALGAGTALLGTKAAMACTEAVETVIGGHYNDQLRETAHLENKAPEFKEIRSHLAEFRDDELEHLNTAVEGWNAKEAPAHALLTNAIQMGCKAAIWMCKRF
What is the function of this protein?
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis.  Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
What are the official names of this protein?
5-demethoxyubiquinone hydroxylase, mitochondrial, DMQ hydroxylase, Ubiquinone biosynthesis monooxygenase COQ7.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: EX7L_LACAC
Sequence: MAENKYLTVTDLNYYITQKFKNDPYLHKVFLQGELSNFRYRRNSHQYFSLKDEKSKINVVMFRSYFDKVKFKPEEGMKVYVTGYVSVYGPQGSYQFYAENMEPAGLGALYEQLKQLQVKLAKEGLFNPEHKKKIPRFPDRIAVVTSASGAVIHDIMVTANRRFPHAEIDLFPAQVQGDTAAESLVRAMRQIAAEGDKYDVMIIGRGGGSLEDLWPFNEEEVVRQVYNMQMPVISSVGHETDTTLCDLVADARAATPTAAAEYATPNLMDELAGIHQLQSRLFSSMQTIIRQKRDRLNRIQNSIIMREPTRLYDQQIETVDRLKQRLQNSMQNKLDHSKQDYRLLNQRLFAVNPDKQINQMKQQRLFLAKRLSDNMQHYLKDKRNIFAQIVQQLDDYSPLKTLERGFVYTTDRDGKTISSVKQVNKNDSLNLHFKDGQVAAKVVEVKEEKNANEEK
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATRX_DROME
Sequence: MGKKNPNARHTDAATPLTTDDSNSSSVSRRESATESKSASESESSPPRSNTKQSRTHKNVKASGKATVSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSRGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKNASIIELSDSEEVDEEEESLLVAIPLPKEAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEEEERKSSGDEEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMELYSYELKPSTEREMPILPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHENLTEEERKSAWAEYEAEKTRTVQASQYMSYDRNAFGNQVMGQFGNASGSVTSNKIFGFRSDILLQLLNMKISKDHQELNQNQVIQLVPTYLQQLYNEMNNGDPTMYKDLLNLHSNIVHPSGMYMNPLLYANQNPNAAGYNQGTGGVPPMAGGSVAHGPPAAPAPGFEPDKVYEID
What is the function of this protein?
Global transcriptional regulator.  Modifies gene expression by affecting chromatin.
What are the official names of this protein?
Transcriptional regulator ATRX homolog, ATP-dependent helicase XNP, X-linked nuclear protein, d-xnp, dXNP.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to pericentric heterochromatin associated with the X chromosome.
Protein: Y1912_CORU7
Sequence: MSQPNMNDIMAQAQRMQKQLQEAQAEIVASSIVGEAGNGKVTLVLSGGGEVQDLKIDQEVVDPEDVETLQDLIIGAFQDANQKLQDLAQEKMGPLADLGGGGLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein cu1912.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SRTA_STRA3
Sequence: MRNKKKLHGFFNFVRWLLVVLLIIVGLALVFNKPIRNAFIAHQSNHYQISRVSKKTIEKNKKSKTSYDFSSVKSISTESILSAQTKSHNLPVIGGIAIPDVEINLPIFKGLGNTELSYGAGTMKENQIMGGQNNYALASHHVFGLTGSSKMLFSPLEHAKKGMKVYLTDKSKVYTYTITEISKVTPEHVEVIDDTPGKSQLTLVTCTDPEATERIIVHAELEKTGEFSTADESILKAFSKKYNQINL
What is the function of this protein?
Transpeptidase that anchors surface proteins to the cell wall.  Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal.  Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall.  This sortase recognizes a Leu-Pro-x-Thr-Gly (LPXTG) motif, which is cleaved by the sortase between the threonine and glycine residues (By similarity).  Essential for adherence to eukaryotic cells and for binding to fibronectin and fibrinogen (PubMed:15908360).
What are the official names of this protein?
Sortase A.
What is the protein family that this protein belongs to?
Belongs to the bacterial sortase family. Class A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: FNO_METJA
Sequence: MKIAILGGTGDQGFGLALRLAKNNKIIIGSRKKEKAEEAAKKAKEILKQRGIEADIIGLENKDAAKEGDVVILSLPYEYTLSTIKQLKEELKGKIVVSIGVPLATAIGDKPTRLLFPPDGSVAEMVQNVLKESKVVSAFQNVCHAVLEDLDNPVDCDILVCGNDEEAKKVVIDLANQIDGVRAIDCGNLEKSRIIEAITPLLIGLNIKYKSKGTGIRITNLEI
What is the function of this protein?
Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i. e.  the reduction of F420 with NADPH.  Probably functions in the regeneration of NADPH required in biosynthetic reactions.
What are the official names of this protein?
F420-dependent NADP reductase, F420H2:NADP oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the F420-dependent NADP reductase family.
Protein: Y453_STAA3
Sequence: MRGGGNMQQMMKQMQKMQKKMAQEQEKLKEERIVGTAGGGMVAVTVTGHKEVVDVEIKEEAVDPDDIEMLQDLVLAATNEAMNKADELTQERLGKHTQGLNIPGM
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein SAUSA300_0453.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PANC_SHIBS
Sequence: MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSSIADKLQAGERDLDEIIAIAGQELNEKGFRADDIQIRDADTLLEVSETSKRAVILVAAWLGDARLIDNKIVELA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCX11_MESMA
Sequence: GRDAYIADSENCTYT
What is the function of this protein?
Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (TTX-S Nav) in rat dorsal root ganglion (DRG) neurons in a concentration- and voltage-dependent manner.  Lowers the activation threshold and produces negative shifting of TTX-S sodium current activation curve.  Induces shifting of the steady-state inactivation curve to the left, delays the recovery of TTX-S I(Na) from inactivation.
What are the official names of this protein?
Toxin BmKNJX11.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENL19_ARATH
Sequence: MGRSMVLISAVVLAFLVAAPIPEVTAKKYLVGDKKFWNPNINYTLWAQGKHFYVGDWLYFVFYRDQHNILEVNKADYEKCISNRPIRNYTRGAGRDIVPLYETRRYYLLDGRGGCVQGMKLDVLVETPPPPPPFTPPPPAQ
What is the function of this protein?
May act as a carbohydrate transporter.
What are the official names of this protein?
Early nodulin-like protein 19, AtENODL19, Phytocyanin-like protein ENODL19.
What is the protein family that this protein belongs to?
Belongs to the early nodulin-like (ENODL) family.
Protein: YDIT_ECOLI
Sequence: MSQNATVNVDIKLGVNKFHVDEGHPHIILAENPDINEFHKLMKACPAGLYKQDDAGNIHFDSAGCLECGTCRVLCGNTILEQWQYPAGTFGIDFRYG
What is the function of this protein?
Could be a 3Fe-4S cluster-containing protein.  Probably participates in a redox process with YdiQ, YdiR and YdiS.
What are the official names of this protein?
Ferredoxin-like protein YdiT.
What is the protein family that this protein belongs to?
Belongs to the bacterial-type ferredoxin family. FixX subfamily.
Protein: MURD_PEDPA
Sequence: MKSVEDLEDKNVLVLGMAKSGISAALLLHRLRANVLVNDANANQPQELIEKLENKGIRMVLGEHPTNILSQNKIELIVKNPGIPYTNPVLVDAQARGIKIVSEPELAYWVMDSELIGVTGSNGKTTVTTLIQLMLDDNKKHAYVAGNIGVPATTVAQKATAEDKIVMELSSFMLAGIDRLHPHIAVLNNIFASHLDWHKTRENYVNDKMNITKNQTKDDFLVINWDNTEWQELAKRTQAKVVPFSRQGLTKSGAYEIEGKLYFKDELIMEADEIGIPGEQNVENALAAIAVAKIEKVSTAHIKQVLTTFGGVKHRIQYVENLNGRQFYNDSKATDIEATQVALRSFKKPVILIAGGLDRHDDLDRLIPDLEPNVKEVIVNGETAEKFKKIAQKAGISVIKDSSRVSESVEIAYQDSKEGDIILLSPAAASWDQYKTFEERGDEFIAAVQNLHKGE
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_ECO24
Sequence: MSLFDKKHLVSPADALPGRNTPMPVATLHAVNGHSMTNVPDGMEIAIFAMGCFWGVERLFWQLPGVYSTAAGYTGGYTPNPTYREVCSGDTGHAEAVRIVYDPSVISYEQLLQVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAAMLAADDDRHITTEIANATPFYYAEDDHQQYLHKNPYGYCGIGGIGVCLPPEA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: LEGL_PONAB
Sequence: MAGSVADSDAVVKLDDGHLNNSLSSPVQADVYFPRLIVPFCGHIKGGMRPGKKVLVMGIVDLNPESFAISLTCGDSEDPPADVAIELKAVFTDRQLLRNSCISGERGEEQSAIPYFPFIPDQPFRVEILCEHPRFRVFVDGHQLFDFYHRIQTLSAIDTIKINGDLQITKLG
What is the function of this protein?
Does not bind lactose, and may not bind carbohydrates.
What are the official names of this protein?
Galectin-related protein, Lectin galactoside-binding-like protein.
Protein: Y1050_BRUA2
Sequence: MTALILKRVAQAIPVMLIVAILTFLLMKLLPGDPAILIAGDGASPETVERIRVELGLDQPTVVQLGQWLWNLFHFDLGRSFLLSQPVSQAIAERLPVTISLALLAFAITIPVGIIMGVVAAYLRDSWFDTGVMSLALLGVSVPSFWLAILAVILFSVTLGWFPSAGYVPFLDSPLGWLRSLILPASILALFQIGYLARMTRSEMLEVMDQDYIRTARSKGVSEYSVLSTHAFRNALVSVLTVSGYIFSLLIGGSVVIEQIFALPGLGRLLVQAILARDLPVVQGTMLFLGFLFVAINVLVDILYTIADPRVRYD
What is the function of this protein?
Probably part of an ABC transporter complex that could be involved in peptide import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Putative peptide transport system permease protein BAB2_1050.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MOAC_HAEI8
Sequence: MTTFTHINSQGEANMVDVSAKAETVREAHAEAIVTMSKETLAMIVEGKHHKGDVFATARIAGIQAAKRTWELIPLCHPLLLSKVEVNLEPLLETNQVRIQSLCKLTGKTGVEMEALTAASVAALTIYDMCKAVQKDIVIEQVRLLEKCGGKSGHFIAEEK
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: RPOA_PSELT
Sequence: MIEYVIPKKLKIEEERSETEYYYARYVLSPMEKGYGTTIGNALRRVLLSSIPSVAIVGIRFIKPEKYHEFDTLPGVKEDILEIILNLKRIQLRADVPVRERVKMTVEKRGPGNLTAADIKVPAGFEIANPSLKIATLDEEADLFFELYAQAGKGFVPAQEMDDHPEIGWIPIDGVFSPVMKVNFRVESARVEKRTDYDKMILEIWTKKTIFPNEALKRAVDILMNHLQIITDSLPEGMPPLTTEFVPISQEEVKVEQTVSEEEAVYSKKIDELELTIRSLNCLRRDKIETIGDLLKRTEEDLLKIKNFGPKSLDEVKQKLLEKFGLSLKKGG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: MDTK_YERE8
Sequence: MQKYIVEARSLLALAIPVVIAQLSQTAMGVVDTIMAGSVSATDMAAVAVGTSIWLPAILFGHGLLLALTPTVAQLNGSGRRNQIAHQVRQGFWLAFCVSVLIMVVIYNSDHIIMRMHNIDPVLADKAVGFLHAIMWGAPGYLFFQVLRNQCEGLSKTKPGMVIGFIGLLVNIPINYIFIYGKFGAPALGGVGCGVATGTVYWVMFLMMRWYVTRARSQQDIKLEKGFAAPDWQVMKRLGGLGLPVALALFFEVTLFAVVALLVSPLGIVAVAGHQIALNFSSLMFMLPMSLSVAATIRVGFRLGQGSVDDARVAAYTSIAVGLMLACVTAIFTVVFREHIALLYNKTPEVVVMASHLMLLAALYQLSDAIQVIGSGVLRGYKDTRSIFFITFTAYWLLGLPSGYLLGLTDYIVPAMGPSGFWIGFVIGLTSAAILMALRIRWLQKQPSAFILQKAAH
What is the function of this protein?
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
What are the official names of this protein?
Multidrug resistance protein MdtK, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AMPA_ACIB5
Sequence: MKFTTYTTFPEQTSNESLWILVDSEQLQSNLNTYQINNLESILTATQFKANFNETLPLFGQLSTQPHSQLLGLGKAAELQAAKLAKLAQTIIKSAQNKFKHIAIDIAALPVEYHYLFALSLTQAAYGYDEFKSKKNEFVLQQVDLISSQTSLDENQLALVHAVQSGQSYARDLGNRPGNICFPEYLAEQALALAAEFPDLLKVTVLNEQQMADLGMYAFLAVSKGSERPGRIVTLEYQAQLEQAPVVLVGKGVTFDTGGISLKPGLGMDEMKFDMCGAASVLGTIRALCEARLPIHVVGAIAAAENMPSGKATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYIKRFNPAVVIDIATLTGACVVALGKVLSGLFSPDDTLAAELQQAGEQSFDRVWRMPVIDDYQELLDSPFADIANIGGPHGGAITAACFLERFTRDYRWAHLDVAGTAWLSGSAKGATGRPVPLLMQFLANRVSTNG
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAA2_SHEDO
Sequence: MVQKIKAFLSQESSGGILLMLAVAMAMLLANSPLAGLYQGFLDTPVQVRFGQLDINKPLLLWVNDGLMALFFLLIGLEVKRELVEGALSSVSKASLPTFAAIGGMVFPALVYLGFNFGNEATQNGWAIPAATDIAFALGVLALLGNRVPVALKVFLLALAIIDDIGVIVIIALFYSSDLSITSLVIAAIAIGSMVILNLKGVRTLTPYALLGLLLWIAVLKSGVHATLAGVVIAFCIPLKVKPGEESPSRYLEHSLHPWSTFMILPLFAFANAGLSLSGMSLASLAEPAALGVMLGLLLGKPLGVLLFSYAAVKLKWASLPQGVNWQQISAVAVLCGVGFTMSIFISSLAFEHSAVDVGNYARLGTLVGSMLSASIAYFWLTKVLNDDKGETDENKNS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 2, Sodium/proton antiporter NhaA 2.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MATK_LACFR
Sequence: MEELQSYLKIDRSRQKHFLYPLLFQEYIYALTHDHGLNGSIFYESIENLGYDKKSSSLIVKRLIIRMHQQNFLILFVNDFRQNQNNKNLDSQIISDAFAVIVEIPFSLQLVSCLEDKKIAKYQNLRSIHSIFPFLEDKLTHLNYVLNILIPYPIHLEILVQTLRRWIQDAPSLHLLRFFLHESGNSNSFISPKKSISFFSNGNFRFFLFLYNSHVYECESLFVFLRKQCSYLRSISSGAFLERTYFYGKIEYLVIVLCNDFQRALCLFKDPFMHYVRYRGKSILASKATYLMIKKWKYHLVNLWQCHFHFWSQPGRIHIDQLYNHSLHFMGYLSSVRITPSVVRSKMLDNSYLIDNSIRKFETVVPIISLICSLAKAKFCNGSGHPISKPARSDSSDSDIIDRFGRICINLSHYYSGSSKKRSLYRIKYILRLSCARTLARKHKSTVRTFLKRFGSFFLEEFFTEAEEVLSLIFPRTPFSSHRFHKDWIWYLDIIRIHDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RSMH_PSELT
Sequence: MEIVHVPVMVKEVLSYFSNLRGVFLDCTVGAGGHSEAILENIKGSVVIGIDVDEEILSVAKQRLKKYESEGRAKLLKATYVEAQRVLSQLGVKAVNGIIMDLGVSTLQLMKGERGFAFSSDGPLDMRMDKTQRLTAYDIVNFWQENQLRRIFFEYGEEKRYAGRIARFIVKNRPVETTAKLVEVIARALPEKERRFRRRHFATRVFQAIRIAVNNELENLRNFLVQVPDILNQNGRIIVISFHSLEDRIVKEAFRSIQELDVLTRKPVRPSLEEVRENPKARSAKMRIAERK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_BACHK
Sequence: MTAIRYEFIKTCKQTGARLGRVHTPHGSFDTPTFMPVGTLATVKTMSPEELKAMDSGIILSNTYHLWLRPGHEIIREAGGLHKFMNWDRAILTDSGGFQVFSLSDFRRIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPFPATFEYMKKSVERTSRWAERCLKAHERPQDQGLFGIVQGGEFEELRRQSAKDLVSMDFPGYAVGGLSVGEPKDIMNRVLEFTTPLLPDNKPRYLMGVGSPDSLIDGAIRGIDMFDCVLPTRIARNGTCMTSEGRLVVKNAKFARDFGPLDPNCDCYTCKNYSRAYIRHLMKCDETFGIRLTSYHNLHFLLNLMEQVRQAIREDRLGDFREEFFEQYGFNKPNAKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.