PharMolix/UniProtQA huggingface dataset:
Protein: PNP_AFIC5
Sequence: MFNTHSVELDWGGRPLKLETGKVARQADGAVIATYGETVVMATVVSAKTPKEGIDFLPLTVNYQEKTYAAGRIPGGYFKREGRPSEKETLVSRLIDRPIRPLFADGYRCDTQVIVTTLSHDMENDPDIVAMVAASAALTLSGVPFMGPVGAARVAFVNNEFILNPTLDEMVDTQLDLVVAGTATAVLMVESEAKELPEEIMLGAVMFGHKHFQPVLKAIIELAEQAAKEPRDVVATVNADLEKEILGIVEQDLRKAYSIPVKQDRYAAVGAAKDKVLEHFFPEGIEPRYEKLRVLDVFKDLEAKIVRWNILDTGRRIDGRDLKTVRPIVAEVGVLPRAHGSALFTRGETQALVVTTLGTGEDEQYIDSLAGTYKETFLLHYNFPPFSVGETGRIGSPGRREIGHGKLAWRAIHPVLPAHHEFPYTLRVVSEITESNGSSSMATVCGSSLALMDAGVPLKRPTAGIAMGLILEGDRFAVLSDILGDEDHLGDMDFKVAGTEKGVTSLQMDIKIAGITEEIMKVALTQAKDGRMHILGEMAKALTAARAELGEHAPRIEVLQIPTDKIRDVIGTGGKVIREIVEKTGAKINIEDDGTVKVASANGESIRAAIKWIKSITSEPEVGQIYDGTVVKVMEFGAFVNFFGPKDGLVHISQLAASRVQKTSDVVKEGDKVKVKLLGLDDRGKVRLSMKAVDQTTGEDLEAKQKAENAPAAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4M_BOTER
Sequence: PIAGSMVLAAILLKLGGYGIIRMMQALPTTKTDMFLPFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVVATIIIQTPWGLSGAMALMIAHGFTSSALFCLANTTYERTHTRILILTRGFHNILPMATTWWLLANLMNIAIPPTMNFTGELLITSALFNWCPTTIIMLGLSMLITASYSLHMFLSTQMGPTPTNNQTEPTHSREHLLMVLHLTPLMMISLKPELII
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: Y1759_MANSM
Sequence: MPSFDIVSEITMHEVNNAVENANRILSTRYDFRGVEAVIELNEKNETIKLTTESDFQLEQLIEILIGACIKRNIDSTSLDIPTESEHHGKLYSKEVKLKQGIETETAKKITKLIKDSKLKVQTQIQGEQVRVTGKSRDDLQAAIQLVKGAELGQPFQFNNFRD
What are the official names of this protein?
UPF0234 protein MS1759.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: DNAE2_BRASO
Sequence: MTPIPYAEIGVTTNFSFLHGGSHPQAYVHQAAEYGLTAIGIADHNTLAGIVRAYSELSNDQLGYRPKLLYGARLVFTCGTPDILVYPRDRAAYGRLCQLLTRGKRGSDLDKVAKGDCRLAFEDLFDFIAGQLLVLMPPHRFDEDALGAILARLKDSPAEGVWLAGSLLYRGDDRRRLARLARLAASAKVPLIATNDVLYHHPQQRMLQDVLTCIREKASIESIGRRLQANAERHLKPGHEMARLFRDHPEAIAETLRFTDRIVFSLDQLKYQYPDEPVPPGKTAQGHLEDLTWAGAKTYFGDKLDDRLRAVLNKELALIAELNYAHYFLTVHDIVRYARSEGILCQGRGSAANSAVCYVLGITSVDPTKIDLLFERFISKERLEPPDIDVDFEHSRREEVMQYVYHRYGRHRAAIIATVIHYRPRSAIRDVGKALGLTEDVTSVLADTVWGSWGDGLSDMQVRQAGLDPHNPMIRRAVELASELITFPRHLSQHVGGYVLTQDRLDSYVPIGNAAMDDRTFIEWDKDDVDALSMMKVDVLALGMLTCIRKSFDLIADHKGRRYVLSDIKSEDDNEVYQMLQRGESLGVFQVESRAQMNMLPRLKPRTFYDLVIEVAIVRPGPIQGDMVHPYLRRRNKLEKVTYPSPSPDHGPSDELYKVLHKTLGVPLFQEQAMRIAIEAAKFSPEEANGLRRAMATFRNVGTIGSYEEKMVSNMIARGYDPAFAKSCFDQIKGFGSYGFPESHAASFAQLVYVSSWLKYFHPDAFCCALLNSQPMGFYAPAQIVGDARKNGVEIRDIDVSHSFADNTLEKTDGEYCAVRLGFRQIDGFRWIDRDEERIRKLSEAVRKEALSVSTRSLPAISPVSFRGARSANPESRDSGFALRAPRNDNDRQIPLHNDDREDDWADRIIRARQRRPFTSLEDFARDTALPKRALLLLADADAFRSLGLDRRAALWAVRRLPDDVPLPLFEAAIAREQPDEGAQPLPEMPLPEHVVADYQTIRLSLKGHPMEFLRRRFAAEGVLACRDVNDTNDRRRIRCAGVVLVRQRPGSAKGVVFMTLEDETGIANIVVWPKVMETFRKEVMGARLVLVEGRIQSSPEKVVHLVAERLVDRTADLTLLSDDRLDAIPHGATPAEPLNDDRRDHTDNPSQRVSHPRNVRILPRSRDFH
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOL3_ARATH
Sequence: MANNAAACAERATNDMLIGPDWAINIELCDIINMEPSQAKEAVKVLKKRLGSKNSKVQILALYALETLSKNCGESVYQLIVDRDILPDMVKIVKKKPDLTVREKILSLLDTWQEAFGGSGGRFPQYYNAYNELRSAGIEFPPRTESSVPFFTPPQTQPIVAQATASDEDAAIQASLQSDDASALSMEEIQSAQGSVDVLTDMLGALDPSHPEGLKEELIVDLVEQCRTYQRRVMALVNTTSDEELMCQGLALNDNLQRVLQHHDDKAKGNSVPATAPTPIPLVSINHDDDDDESDDDFLQLAHRSKRESARGTGQGNFNPILPPPPSSMRPVHVDSGAMDFLSGDVYKPQETFENVKPPSTSQSSNHDYSAPIFDEPVPQSKSPEHALFTKPVYDQTEQLPPAPWETQEPRKYPPSMSARTNKRPEYFQHNVPQHSSSASESSYDDLLGQSRNLSLNPTASAAPVTPPKKDDKPEDILFKDLMDFAKTRTSSSSSSKPNNQNNKPF
What is the function of this protein?
Might contribute to the loading of the ESCRT machinery.
What are the official names of this protein?
TOM1-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the TOM1 family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: Y1117_BACP2
Sequence: MKYGVVLFPSKKLQDIANSYRKRYDPNYALIPPHLTLRTPFELTDLEAAEVVSTLREYAKNASPITLRIKKFSSFAPVNNVIYMKVEPNEEIMALNERLYADPLEGTPEYAFVPHVTVAQKLSDDEHSDVLGTLKLRKIDHEETVDRFHLLYQLENGSWTVYETFILGEEG
What are the official names of this protein?
Putative phosphoesterase BPUM_1117.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. YjcG family.
Protein: YIIE_SHIF8
Sequence: MAMNTVFLHLSEEAIKRLNKLRGWRKVSRSAILREAVEQYLERQQFPVRKAKGGRQKGEVVGVDDQCKEHKE
What are the official names of this protein?
Uncharacterized protein YiiE.
What is the protein family that this protein belongs to?
Belongs to the YiiE family.
Protein: GLSA_EXISA
Sequence: MNVLEQQLNHLVDECRPYTAQGKVADYIPELAHVKNDLLGVAICLPDGTYIHAGDVHHKFTIQSVSKALTLCYVLMEFGEDYVFSKVGMEPTGDAFNSIAKLEETVPSKPLNPMINAGALAVTSMILGETAELKIYQFRQFLATLLNRSVEEVTYDEKVARSEYETTDLNRALLYFMRHHGIVEGDVDEIIDVYTKQCAIEIDCFDLARIGRVFAGNGEDPDTGEELIPRRVVRIVKAIMTTCGMYDASGEFAVRVGLPGKSGVSGAILAVGNHELDLNNVGFGIFGPALDSKGNSIAGMKLLELLIERYTSR
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: ZUPT_ECO8A
Sequence: MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFGLDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSVMGFSLVLLQTAGIG
What is the function of this protein?
Mediates zinc uptake.  May also transport other divalent cations.
What are the official names of this protein?
Zinc transporter ZupT.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PAK2_RABIT
Sequence: MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRNKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGAPALNTKVSETSAVVTEEDDDDEEAAPPVIAPRPDHTKSIYTRSVIDPIPAPVGDSHVDSGAKSSDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR
What is the function of this protein?
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation.  Acts as downstream effector of the small GTPases CDC42 and RAC1.  Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.  Full-length PAK2 stimulates cell survival and cell growth.  Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration.  Phosphorylates JUN and plays an important role in EGF-induced cell proliferation.  Phosphorylates many other substrates including histone H4 to promote assembly of H3. 3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP.  Phosphorylates CASP7, thereby preventing its activity.  Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis.  On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway.  Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PAK 2, Gamma-PAK, p21-activated kinase 2, PAK-2, p21-activated protein kinase I, PAKI.
What are the subcellular locations of this protein?
[Serine/threonine-protein kinase PAK 2]: Cytoplasm. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane. SUBCELLULAR LOCATION: [PAK-2p34]: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region.
Protein: SYC_SYNP2
Sequence: MSLSLYNTLHRRSEPFEPLEANLVRMYCCGITVYDYCHLGHARTCLIWDVVRRYLQWSGYEVHYIQNFTDIDDKILNRARAEKSSMGAIAEKFIEAYFEDMEALHIQPADEYPRATHSLDGIQKLIHDLEQRGFAYASQGDVYYAVRKFDGYGKLSGRKLDDMQAGASGRVNEDPDAPKKHDPFDFALWKAAKAGEPAWDSPWGAGRPGWHIECSAMVRDRLGETIDIHVGGSDLIFPHHENEIAQSEAATGQPLAKYWLHNGMVKVEGEKMSKSLGNFITIRELLKKYDPMAVRLFILQAHYTKPLDFTDEALTAATKGWETLNDALLFGAEHLDTNNITADKGILAKFKAIVDNDLNFSGGLAILFELAKELKKEKNILVHEGKLQQNPQILASLWLTLKELADILGFVPETKQQAAGLTDAEIEDLIQQRKDARANKNYAEGDRLRDLLAEKGIVLVDKPGGITEWHRE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNL_PETHY
Sequence: MDELPKCGANYVPLTPLTFLTRAFKSYANRTSIIYAGARFTWEQTYKRCCRLASSLQSLNIVKNDVVSVLAPNVPATYEMHFAVPMAGAVLNTINTRLDPMNIAIILKHSEAKLLFVDYEYLEKARKALELLMSTNFITAQNSKKISMPQVILIDDLYSPTRIQQQDQLEYEQLVHQGNPEYAPENIVDDEWDPIVLNYTSGTTSEPKGVVYSHRGAFLSTLNTIMGWEMGTEPVYLWSLPMFHINGWTLTWGIAARGGTNVCIRNTTAQEIYSNITLHKVTHMCCAPTVFNILLEAKPHERREITTPVQVMVGGAPPPTTLIGKIEELGFHVVHCYGITEAGGTTLVCEWQSEWNKLSREDQANLKARQGISVLALEDVDVKNSKTMQSVPHNGKTMGEICLRGSSIMKGYFKNDKANSQVFKNGWFLTGDVAVIHQDGYLEIKDRCKDIIISGGENISSIEVENAILKHPSVIEAAVVAMPHPRWGETPCAFVIKTKNPEIKEADIIVHCKKELPGFMVPKHVQFLEELPKTGTGKVKKLQLREMAKSFGIFDNANQTSQILDLPARL
What is the function of this protein?
Involved in the biosynthesis of floral volatile benzenoid/phenylpropanoid (FVBP) scent (e. g.  benzylbenzoate, phenylethylbenzoate, and methylbenzoate) (PubMed:22771854, PubMed:22649270).  Catalyzes the formation of CoA esters of cinnamic acid, and, with lower efficiency, of 4-coumaric acid and caffeic acid (PubMed:22649270).
What are the official names of this protein?
Trans-cinnamate:CoA ligase, peroxisomal, Cinnamic acid:CoA ligase, Ph-CNL, PhCNL, (E)-caffeate:CoA ligase CNL, 4-coumarate:CoA ligase CNL, Protein ACYL-ACTIVATING ENZYME, PhAAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome. Note=Located in the peroxisomes of flower petal limb cells.
Protein: VAPB_PIG
Sequence: MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPADTSDMEAAWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPVVSKALSSALDDTEVKKVMEECKRLQSEVQRLREENKQLKEEDGLRMRKPVLSNSPAPAPATPGKEEGLSTRLLALVVLFFIVGVIIGKIAL
What is the function of this protein?
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity.  Involved in cellular calcium homeostasis regulation.
What are the official names of this protein?
Vesicle-associated membrane protein-associated protein B, VAMP-B, VAMP-associated protein B, VAP-B.
What is the protein family that this protein belongs to?
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Protein: SERC1_HUMAN
Sequence: MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAAVHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFVYYTHPASCSENKAFISVNMLLCVGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETNCNPSLLSIIGYNTTSTVPKEGQSVQWWHAQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGARSDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD
What is the function of this protein?
Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
What are the official names of this protein?
Serine incorporator 1, Tumor differentially expressed protein 1-like, Tumor differentially expressed protein 2.
What is the protein family that this protein belongs to?
Belongs to the TDE1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GGPPS_BOVIN
Sequence: MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLNHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLDTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLENVGSFEYTRNTLKELESKAYKQIDARGGNPELVALIKHLSKMFKEENE
What is the function of this protein?
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
What are the official names of this protein?
Geranylgeranyl pyrophosphate synthase, GGPP synthase, GGPPSase, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, myofibril, sarcomere, Z line.
Protein: RIMP_SALDC
Sequence: MSTLEQKLTEMITAPVEALGYELVGIEFIRGRTSTLRIYIDSEDGINVDDCADVSHQVSAVLDVEDPISVAYNLEVSSPGLDRPMFTADHYARFQGEEVALVLRMAVQNRRKWQGIIKAVDGEMITVTVEGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INS3B_CONGE
Sequence: MTTSFYFLLVALGLLLYVCQSSFGNQHTRNSDTPKHRCGSELADQYVQLCHGKRNDAGKKRGRASPLWQRQGFLSMLKAKRNEAFFLQRDGRGIVEVCCDNPCTVATLMTFCH
What is the function of this protein?
This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock.  It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor (INSR) and assembly of the hormone's hexameric storage form.  Despite lacking this segment, it both binds and activates human insulin receptor (long isoform (HIR-B)) with only a 10-fold lower potency.  In vivo, intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin.  In addition, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency.
What are the official names of this protein?
Con-Ins G3b, Insulin 3b.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DDX1_CHICK
Sequence: MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETLKDQMEGKKGKATIKTGGAVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATRGVTKGKYYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDSYGEEFTMHDTIGCYLDIDKGQIKFSKNGKDLGLAFEFPPHIRNQALFAACVLKNAELKFNFGEEDFKFPPKDGYIGLCKAPDGNVVKSQHTGNAQVVQTQNLPNAPKALIVEPSRELAEQTLNNVKQFKKYIDNPKLRELLIIGGVAARDQLSVLEQGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLLQGYSDFINRIHSQIPQITSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPETVHHVVVIVNPKTDKLWERLGKNHIRTDEVHAKDNTLPGANTPEMWSEAIKILKGEYTVRAIKEHKMDQAIIFCRTKIDCDNMEQYFIQQGGGPDRKGHQFSCVCLHGDRKPQERKQNLERFKRGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVAKEKEKVWYHVCSSRGKGCYNTRLKEEGGCTIWYNEMQLLGEIEEHLNCTISQVEPDIKVPVDDFDGKVTYGQKRALGGGLYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQLFRTF
What is the function of this protein?
Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes.  Possesses 5' single-stranded RNA overhang nuclease activity.  Acts as a positive regulator of transcription.  May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs.  Binds DNA and RNA.  Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB (By similarity).  Binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DDX1, DEAD box protein 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, cytosol. Mitochondrion.
Protein: AUP1_XENTR
Sequence: MEQPSVESLLELRRFPRKQLSLILLLLYSPLGLCLFLIRLFIGAHVFLVSCVLPDSVFRRFLLRVMSSVLGVYVSHSALRPLERRGKILICNHRTDFDHNIISLIAPCCSPSLSCAPGFLCWARGFLELGALGSRTQLMESLKHYLSQPGGGPLLLFPEEETTSGRTGLLHFSSWPFSLSDSVQPLTLTVQRPLVAAAVSGCSWVTELFWLLFIPFTVYQVRWLPPVTRHTRESDEEFAFRVQQMMAGSLGVAATRHTGADRAEYLKRRRTELPRSAPRSVPLSPTQMQMAQHVKEVLPQVPLSAIHRDLGHTGCIDTTITNFLEGRVTFLPEEETLGGNEATERTPLDRISRPLPRGFAKSPEVRHLSLQERKEALYECARRKYLEKFGSVGREEEEKGARG
What is the function of this protein?
Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity).  Plays a role in lipid droplet formation (By similarity).  Induces lipid droplet clustering (By similarity).
What are the official names of this protein?
Lipid droplet-regulating VLDL assembly factor AUP1, Ancient ubiquitous protein 1.
What is the protein family that this protein belongs to?
Belongs to the AUP1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet.
Protein: AIP1_YEAST
Sequence: MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNVVLE
What is the function of this protein?
Involved in the depolymerization of actin filaments.  Enhances the filament disassembly activity of cofilin and restricts cofilin localization to cortical actin patches.
What are the official names of this protein?
Actin-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat AIP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, actin patch.
Protein: RL32_NEIMB
Sequence: MAVQQNKKSPSKRGMHRSHDALTAPALSVDSTTGEVHRPHHISPNGMYRGRKVVKAKGE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: ZC3HF_DICDI
Sequence: MPPKQAQSKKTVEKEKKKKVEDKTFGLKNKNKSKKVAAYVSQVEAQVKHSGLQNKEAALKEKAKRDKELAEKAKKEAESILVNTIVQSKVPLGVDPKSIVCEYFKQGVTCPKGNRCKFAHDLAAGRKSEKIDIYTDRRKDEDTMENWDEAKLKSVVEKKRTTENKAKPTAIICKFFLDAIESKKYGWFWECPNGGEKCAYQHCLPEGYQLKKKKSREEDEVEEIPIEELIEEERAKLTKSTPVTLETFLRWKEEKRLQKEKAAKDAQDKRLADIKAGKTSMSGREMFVFNPDLFVDDESAIDTKSKEYEKSEEEIAALANQINTSLFTDGGVLPSDDDDDDDDDDDDDEDGDDEEEDDDEEEGEYEEEEASDE
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 15 homolog.
What is the protein family that this protein belongs to?
Belongs to the ZC3H15/TMA46 family.
Protein: KCNN1_HUMAN
Sequence: MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
What is the function of this protein?
Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:8781233, PubMed:9287325, PubMed:17142458).  Activation is followed by membrane hyperpolarization (By similarity).  Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity).
What are the official names of this protein?
Small conductance calcium-activated potassium channel protein 1, SK1, SKCa 1, SKCa1, KCa2.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DIAC_MOUSE
Sequence: MALCGLPEFTLLLLPLLARLSAGDCPCSEAALCQPIRHRPDFEVFVFDVGQKTWKSYDWSQITTVAAFGKYDPELMCYAHSKGARVVLKGDISLKNIIDPTFRASWIAQKVDLAKAQYMDGINIDIEQEVNCSSPEYEALTALVKETTESFQREIEGSQVTFDVAWSPKRIDKRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGYIDYIKMGISPKKLVMGVPWYGYDYICLNLSKDDICTITKVPFRGAPCSDAAGHQVPYKVIMKQVNGSVSGSQWNKDQQAPYYNYKDPAGRFHQVWYDNPQSISLKAAYVKNYGLRGIGMWNANCLDYSDDALAREQTQEMWGALKPRL
What is the function of this protein?
Involved in the degradation of asparagine-linked glycoproteins.  Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase (By similarity).
What are the official names of this protein?
Di-N-acetylchitobiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: APC16_PONAB
Sequence: MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Anaphase-promoting complex subunit 16, APC16, Cyclosome subunit 16.
What is the protein family that this protein belongs to?
Belongs to the APC16 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome, centromere, kinetochore.