PharMolix/UniProtQA huggingface dataset:
Protein: BIRC3_HUMAN
Sequence: MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS
What is the function of this protein?
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis.  Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.  The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10.  Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs).  Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.  Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
What are the official names of this protein?
Baculoviral IAP repeat-containing protein 3, Apoptosis inhibitor 2, API2, Cellular inhibitor of apoptosis 2, C-IAP2, IAP homolog C, Inhibitor of apoptosis protein 1, hIAP-1, hIAP1, RING finger protein 49, RING-type E3 ubiquitin transferase BIRC3, TNFR2-TRAF-signaling complex protein 1.
What is the protein family that this protein belongs to?
Belongs to the IAP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ARGR_ECO45
Sequence: MRSSAKQEELVKAFKALLKEEKFSSQGEIVAALQEQGFDNINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKELYEAILELFDQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y583_STAAM
Sequence: MKLFIILGALNAMMAVGTGAFGAHGLQGKISDHYLSVWEKATTYQMYHGLALLIIGVISGTTSINVNWAGWLIFAGIIFFSGSLYILVLTQIKVLGAITPIGGVLFIIGWIMLIIATFKFAG
What are the official names of this protein?
UPF0382 membrane protein SAV0583.
What is the protein family that this protein belongs to?
Belongs to the UPF0382 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DDX54_DICDI
Sequence: MVKPNNVKIKNKGNLKKSNESQNDYMKGKKLETKSYQKALLSKNSNNNNDGAQAKRLKKKEEFKKKLEKRQNTIVIKDKLKEPSTFLKEDQSFFDQNIFNDQDDYKHQQMNRININENFETNLFGDMMNEFDGDLNEDLDLLDYNDEVIDNSNFDNNGDQFNSEDEEFYDDEKQAKKSNKNKNADADNKKSKKSNKKEEIESSEKFESFPMDENNEQEEETTSKKKKKTGGFQSMDLTKNLLKAILKKGFNVPTPIQRKSIPMILDGHDIVGMARTGSGKTGAFVIPMIQKLGDHSTTVGVRAVILSPTRELAIQTFKVVKDFSQGTQLRTILIVGGDSMEDQFTDLARNPDIIIATPGRLMHHLLETGMSLSKVQYIVFDEADRLFEMGFNEQLTEILSKLSENRQTLLFSATLPSLLVDFVRAGLNNPKLINLDTDTKISENLSLSFFTLRHEEKLGVLLFLLKDIIYKKPQLPTTETTTTTTTNNESNQQQQKKSSTIIFVSTKYHVEFIHILLERAGIASTYIHGYLDPVARKINLAKFRSHQVGVMVVTDLAARGIDIPLLDNVINFDFPPKEKIFIHRVGRVARAGRSGIAYSLVSPDEVPYMIDLHLYLGRKFLNKFQYEGQTINDPKYSFYGTIPQTIIDRETEFVNVQRKECIELLSLTKTIHNAHKKYLSTRPGASHESNRRAKLMDKSKYHPMLSDHLNSNDQIRNDFIQSLKSFRPPQTVLELDARKNNVQVSIMKDKRKVHTNVIESQQKKLYLQQSETNLGPENEEFDYSKLDTRKRLLQLTENITEEMLRSNKSNDNNDNNKDIKMNENDDENDDDDEEGENDDDEEEENEKDEDDEEDENKNKFNIKIESSDKNDNNKKKLKSRSSSRDPNFFISATPENLIQERAMSISNRFTKDDEVNLVADTDRKQKKSMVWDKRKGKFVSSQADADRKNSKKLVRNEAGKLVEAKKSHKGYEEWKKKTHGRIQRVGEDENSKYQPNQKEYLPQKWRGQGREKEKKDNKASHAKGSHGLKGRPSELKDKNQISKNRSEKERKMRVNKTKGNPKGSKSKSGGGGGGKGSKFGSGKSKGGKSRK
What is the function of this protein?
ATP-binding RNA helicase which may be involved in the ribosome biogenesis.
What are the official names of this protein?
ATP-dependent RNA helicase ddx54, ATP-dependent RNA helicase helA, DEAD box protein 54.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DNAA_CLOP1
Sequence: MDAQLNNLWEQALNIIKGEISEISFNTWIKSCTPISISDNILKLSVPNEFTKGILDTRYKDLLIQALKIVTSRKFKIEFYLESDLEEEKENEEKQKEEKKENTNDVDGSIVVSDEMSATLNPKYTFQSFVIGNSNRFAHAASLAVAESPAKAYNPLFIYGGVGLGKTHLMHAIGHYILQENPKAKVVYVSSEKFTNELINAIKDDKNEEFRNKYRKVDVLLIDDIQFIAGKERTQEEFFHTFNALHEENKQIILSSDRPPKEIPTLEDRLRSRFEWGLIADIQPPDFETRMAILKKKADVEGLNVPNEVMVYIATKIKSNIRELEGALIRIIAYSSLTNRDVSVDLASEALKDIISNKESAPVTVKTIQESVANYYNLRIEDLKSQRRTRNIAYPRQIAMYLSRKLTDMSLPKIGEEFGGRDHTTVIHAYEKISENLKTDEGLQSMINDITKKLTQK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_VARPS
Sequence: MSMSDPIADLLTRIRNAQMVAKPTVSVPSSKVKIAISQVLKDEGYIDGFQVKTEDGKTELVITLKYYAGRPVIERIERVSRPGLRVYKASASIPQVQNGLGVAIVTTPKGVMTDRKARATGVGGEVLCYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SSN3_ASHGO
Sequence: MGIRLQSSDSMNNQHQTQQNKYFNVSNQASTRSLWSQQQQQQLLDTKGSASTSKSPMLMANNNVFSIGPYRQRKDAGRVSVLEKYEIIGYIAAGTYGKVYKAKAKETQEEQENSIHTHNQTLGSVSVAGIDGGMASREVENGGDDPLRLDGHGGIAVAPAAGGGLSSAAAHRARSNGAVKALPKKSAFTPFYAIKKFKTEREGVEQLHYTGISQSACREMSLCRELDNKHLTKLVEIFLERKSIYMVSEFAEHDLLQIIHFHSHPEKRLIAPRMLKSIMWQILDGVSYLHQNWILHRDLKPANIMVTVDGCVKIGDLGLARKFYNLVQTLYTGDKVVVTIWYRAPELLLGARHYSPAIDLWAVGCIFAELIGLRPIFKGEEAKMDSKKSVPFQGNQLQRILEVLGTPTHHTWPNIHKYPEYEQLSKFSKYRDNLSVWYHSSGGRDKAALSLLYSLLKYDPITRIDAIDALEHEYFTNNDPPVSSDVFEGLSYKYPPRRIHTSDNDIMNVGANKNKSGFNHHPPQQQTVNNNGVTNSSIGGLGVNRRILAAAAAAAAAVQVNGTNIVSGSSSSNGPIRKKKR
What is the function of this protein?
Component of the SRB8-11 complex.  The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase SSN3, Cyclin-dependent kinase 8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS16_STRT1
Sequence: MAVKIRLTRMGSKKKPFYRINVADSRAPRDGRFIETVGTYNPLVEENQVTLKEERVLEWLSKGAQPSDTVRNILSKEGVMKKFHESKFSK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: GCSH_YERPE
Sequence: MSNVPTELKYALSHEWVRADGDGVYSVGITEHAQELLGDMVFVDLPEVGSDVSAGSDCAVAESVKAASDIYAPISGEIVAVNTELENSPELVNSAPYTDGWLFSIKAADESELDNLLDADAYLAAIEE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: TDCA_ECOLI
Sequence: MSTILLPKTQHLVVFQEVIRSGSIGSAAKELGLTQPAVSKIINDIEDYFGVELVVRKNTGVTLTPAGQLLLSRSESITREMKNMVNEISGMSSEAVVEVSFGFPSLIGFTFMSGMINKFKEVFPKAQVSMYEAQLSSFLPAIRDGRLDFAIGTLSAEMKLQDLHVEPLFESEFVLVASKSRTCTGTTTLESLKNEQWVLPQTNMGYYSELLTTLQRNGISIENIVKTDSVVTIYNLVLNADFLTVIPCDMTSPFGSNQFITIPVEETLPVAQYAAVWSKNYRIKKAASVLVELAKEYSSYNGCRRRQLIEVG
What is the function of this protein?
Transcriptional activator for the tdcABCDE operon.
What are the official names of this protein?
HTH-type transcriptional regulator TdcA, Tdc operon transcriptional activator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: UPPP_METVS
Sequence: MENILLGIVQGLTEFLPVSSSGHLAIFTAIFNKTPDVGYFAFLHLATFLAVVIFVKKEIFEIINGVFKKDEKYITLSLKLFVSMIPAAIVGIFFEDFIKSIFSETFFIGVFLAITGVFMLLSDKMDKNLKTITKIPYLDAFIIGIFQAFSVLPGISRSGSTLFAALLLGVKKEDAVKYSFLMSLPVIFGAGVLEMQKTVITKEYVYGFIVAFLTGILGLHLLKKMVIAGKLKFFGYYCFLASLFVIFYI
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
What are the official names of this protein?
Undecaprenyl-diphosphatase, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAS1_HYPBU
Sequence: MPEVLLVATPGTRIYVRRGVVYAEAPSGEKAVVTADTELVVLATGSVSVSGRALRRLAELGVRLVVLGQRGQVVAEHRPVDRVNRTIEARMEQYRVKATGEALYYAAEMVYAKIVNQAKLLRYLAKSRREPWLRDAGYRVEGHADRLRQIIENEEPTTPEVIRSIEAQAARDYWDAIAQIAPTPFPGRQPRGEDHLNMALSYGYAILYSIAHDALTVAGLDPYAGFLHADRSGRPSLTYDYADTYKPIAVDKPLLTAPRKTDCLDTYMGALTYNARRCIATLVLENIYKTPYPDSRGRKKTLRDHIYTYAWNLAAAIRQHKPYKPFIVGRL
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Acts as a dsDNA endonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endonuclease Cas1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endonuclease Cas1 family.
Protein: HTPX_SALDC
Sequence: MMRIALFLLTNLAVMVVFGLVLSLTGIQSSSVQGLLIMALLFGFGGSFISLLMSKWMALKSVGGEVIEQPRNERERWLMNTVATQARQAGIAMPQVAIYHAPDINAFATGARRDASLVAVSTGLLQNMSPDEAEAVIAHEISHIANGDMVTMTLIQGVVNTFVIFISRIIAQIAAGFLGGNRDEGEGSNGNPLIYFAVATVLELVFGILASIITMWFSRYREFHADAGSAKLVGREKMIAALQRLKTSYEPQEATSMMAFCINGKSKSLSELFMTHPPLDKRIEALRSGEYLK
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FOLB_CHLMU
Sequence: MYRLDVTNFRVWVSIGVSEQERYHKQPILVSVSLVFREEPKVCSTDEISDGICYAALVSLIEQTAANHPCALLERLAKVLLEKLEESLAQFVCKIDLRVSKERPPIPNLLSPVSFSISKEVP
What is the function of this protein?
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
What are the official names of this protein?
Probable dihydroneopterin aldolase, DHNA, 7,8-dihydroneopterin aldolase.
What is the protein family that this protein belongs to?
Belongs to the DHNA family.
Protein: RS20_GLOC7
Sequence: MANIKSAIKRIQIAERNRLRNKSYKSAVKTLMKKYYAAVEDYKANPSEEAKKAVDQAMSAAYSKIDKAVKCRILHRNNGARKKSQLANALKQVTTAS
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: MDM34_YEAST
Sequence: MSFRFNEAVFGDNSFNERIREKLSTALNSPSKKKLDILKSGIKVQKVDFPTIPQLEILDLDIITQPKSLAKGICKISCKDAMLRIQTVIESNLLLINEQDTPSFTMPQLINNGSFTIPITMTFSSIELEAITNIFVKNPGIGISFNDVDLDFKFDCSVKILQSTIERRLKESMHVVFKDVLPSLIFNTSQNWFTNRGESTSTIPGKREHHHQQTTMSRNVILDGSDFQELSPINMLRLSSIVSSRSTLSLHSTVMNSLSAIPGCLERQNLYRFISRMPSLNNYYSSQSFPQPKSSTVSSKQLVKPFYCSHNLLPKTVLDSSQYDLATITKIQSRLFDRSNSNDDNAKPRRRKIKCKKTRTPSNLQSQGEQAVDDSTAIETVTSTPVQTPIPELEEQSPPYLKTTVSIRDKYVIPEKISLNLDSKKDTSKKKPFYFIGLNSQEPSNNWKWGMEDSPPPYH
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria (PubMed:11907266, PubMed:14981098).  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:27469264).  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10 (By similarity) (PubMed:19556461).
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34, Mitochondrial outer membrane protein MMM2.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
Protein: AROC_CHLPD
Sequence: MIRYLTSGESHGPALSAIVEGVPAGVGITPEMINTELARRQQGYGRGGRMKIETDQAEVLSGIRFGKTIGSPITLIIRNRDWENWTTTMSQFSEPAEDIAKITIPRPGHADLTGKIKYGLNDIRPVIERSSARETTARVAAGTISRIFLKAIGIEIGSYISAIGSAGETTADTQIEKLLRSGAETLARKADRSAVRMLDKKKEAEAIIAIDAAKDAGDTLGGIIEIFITGVPMGLGSYMQHDRRLDANLAAALISIQAIKGVEIGTAFANALKPGSQVHDEFIIEPEKGLTRSSNRAGGIEGSMSSGQTIHLRAAMKPISSLLTPLHSFDSETLQPTLSRFERSDTCAVPAAGVVAEAMVSTVIANAVLEKFGGDHLGEIQTRISLHRDLTRKAFIA
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: ISCR_SALPA
Sequence: MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRGPGGGYLLGKDAGSIAVGEVISAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGFLNNITLGELVNNQEVLDVSGRQHTHDAPRASGRAQDAIDVKLRA
What is the function of this protein?
Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.
What are the official names of this protein?
HTH-type transcriptional regulator IscR.
Protein: GCSH_CROS8
Sequence: MSNVPNELKYSKEHEWLRKEADGTYTVGITEHAQELLGDMVFVDLPDVGTTVNAGDDCAVAESVKAASDIYAPVSGEIVAVNDALSDSPELVNSEPYGQGWIFKIKASDEAEVAALLDASAYEALLEDE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RSMA_CAMJR
Sequence: MVKAKKQYGQNFLIDKSVLAKIIQAIPKEMNNIIEIGPGLGDLTQELLKISQVKAYEIDNDLIPILKKKFQKELECGKFNLIHQDASEAFNPSLDEKPYFLVANLPYYVASHIILKALEDKNCLGLIVMVQREMAEKFCAKEGNSEFSSLGVLSAMICERKILFDVDPQCFNPPPKVMSAVMSLIKTKDFDELCEIENFKNFLKDCFKAPRKQLLGNLKTYKAKVLEVLSTLGLKENIRPHEICVDLYLKIYDKLKDEYGRKQRDK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_STRPG
Sequence: MSKQTLVLLYGGRSAEREVSVLSAESVMRAVNYDKFLVKTYFITQMGQFIRTQQFSEKPSESERLMTNETIELTQKIKPSDIYEEGAVVFPVLHGPMGEDGSIQGFLEVLRMPYIGTNVMSSSIAMDKITTKRVLESIGIPQVAYTVYIDGQDLEACLVETLARLTFPIFVKPANMGSSVGISKAQTKVELRKAIQLALTYDSRVLIEQGVVAREIEVGLLGNDKVKSTLPGEVIKDVDFYDYQAKYVDNKITMAIPADVDQSIVTEMRSYAEVAFKALGGCGLSRCDFFLTQDGQVYLNELNTMPGFTQWSMYPLLWENMGLAYPDLIEELVTLAQEMFDQRESHLI
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_NITHX
Sequence: MSGAIRIDAQQLPHAEGLPLPAYHSSQAAGLDLMAAVPEQTPLVLAAGQYAMVPTGLIIALPDGFEAQVRPRSGLAAKHGVTVLNSPGTVDADYRGEINVLLVNLGNAPFTIRRGERIAQMIVAPVTRVELARAVSLSATSRGSGGFGSTGR
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: ATL28_ARATH
Sequence: MSSTTSIDSIPATAVFPSVSMPVTVVLTGVLLFVIFAGFFSLFLWQFLLNRLFTTWNLQRTPYGDLIHVATPPENTGLDPFIIRSFPVFHYSSATKKNHGTECAICLSEFSDEDTVRLITVCRHPFHSNCIDLWFELHKTCPVCRCELDPGMIGSGRLESFHNTVTITIQDINHDEENPPTAGSSKRLIEASAWRFSRSHSTGHFMVKTTDANVKSKRRHYQTGSCVSFDELTRYEGAGWQWLGDSSHISRIEV
What are the official names of this protein?
RING-H2 finger protein ATL28, RING-type E3 ubiquitin transferase ATL28.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RLMD_SHEAM
Sequence: MAQFFKAKPNQAKKLSQKIALKVQRLDHLGAGIAEHQGKVVFIPGALPGETVEVQLTEQKKNYARAKLQRVSEASPDRQTPPCPWYGKCGGCDLQHLSLPRQLEYKRQALGDIVSRSAAQTVTVNTDEVSGDSWHYRRRARLATLLDKETNQLALGFREEGSKSVVGIDSCAVLARPLSELISPFATLLNRLKGKQRLGHLELTQAANGLFAVLRVTAPLAQSDKKLLSAFADERQIALLLQGNEGELEFLSSGHELPYYQLDGLKLAFAPGNFIQVNGEVNQAMVAQAMNWLDVHAGERVLDLFCGVGNFSLPLAKQGAEVVGVEGVPEMVAQAKQNAAINGLDNLSFYCADLSEDLAAEPWLGKIDKLLLDPARAGAYESLKWLKKMKPAKVLYVSCNPASLARDSVLLFEAGYQLTRLGLVDMFPQTHHSEGMALFELVN
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: HIS81_BORPA
Sequence: MSRYWSPVVGTLSPYVPGEQPKLPDLIKLNTNENPYGPSPKALQAIAAAAGDTLRLYPDPASDDLRGAIAAAVGVQADQVFVGNGSDEVLAHVFMALFRHGRPVRFPDISYSFYPVYCGLYEIPYQVVPLTDDFRIDPADYQPGGQAAGGIIFPNPNAPTGRALARDEVERIVTANPDTVVVVDEAYVDFGAESVAPLVDRHDNLLVVQTLSKSRSLAGLRVGFALGSRALIDGLERVKNSFNSYPIDRLASAGAQAAMQDQAYFDRTRQAVMATRERMSADLRALGFDVLPSAANFVFARHPEHDAAQLAARLRERSILVRHFRQARIDQFLRITVGTDAQCEALIGALKKIFSS
What are the official names of this protein?
Histidinol-phosphate aminotransferase 1, Imidazole acetol-phosphate transaminase 1.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: CSK21_RABIT
Sequence: MSGPVPSRVRVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPASRTPALAFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
What is the function of this protein?
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.  Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection.  May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response.  During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage.  Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation.  Can also negatively regulate apoptosis.  Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3.  Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8.  Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis.  Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV.  Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB.  Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function.  Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90.  Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1.  Acts as an ectokinase that phosphorylates several extracellular proteins.  During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.  Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (By similarity).  Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity).  Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment (By similarity).
What are the official names of this protein?
Casein kinase II subunit alpha, CK II alpha.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSAM_CYAPA
Sequence: MLADGQIFTALAVALVPGILALRLALELYKF
What are the official names of this protein?
Photosystem I reaction center subunit XII, PSI-M.
What is the protein family that this protein belongs to?
Belongs to the PsaM family.
What are the subcellular locations of this protein?
Plastid, cyanelle thylakoid membrane; Single-pass membrane protein.