PharMolix/UniProtQA huggingface dataset:
Protein: RL35_STRZP
Sequence: MPKQKTHRASAKRFKRTGSGGLKRFRAYTSHRFHGKTKKQRRHLRKASMVHSGDYKRIKAMLTRLK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: XYLH_SULAC
Sequence: MNILNVVRRFEFQLFLVNVIIALFFYFENSAYFSSNNITTIFQYLAEIGIIAIGEAMLMLCGEIDLSPPALANFVPLITLTIYNSIYQAISPTPAIVVSILLSLGLASLIGLMNGLITTKAKVNSLITTVGTLFLFNGIALIYSGGYPESFPYFRFLGGTVSILPVPFIWSLGALVFLILLLHYTKIGVWTIAAGSNPTGASEVGVPVDRVKIINFIIMANIGALVGIIQGSRVLTIGATNFTADVVLEGIAAAVIGGTSLVGGKGSLVGAFLGSVFISELLNGFNILGINAYEFDAILGGAIVVVMVLSYYAKRASYKLKSIATATSSSPEGKDRITKILKFKIQKIYRRVEENE
What is the function of this protein?
Part of the ABC transporter complex XylFGH involved in the uptake of xylose and arabinose (PubMed:29150511).  Responsible for the translocation of the substrate across the membrane (Probable).
What are the official names of this protein?
Xylose/arabinose import permease protein XylH.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DUT_FUSNN
Sequence: MKKVQVKVIREEGVELPKYETEGSAGMDVRANIKESITLKSLERILVPTGLKVAIPEGYEIQVRPRSGLAIKHGITMLNTPGTVDSDYRGELKVIVVNLSNEAYTIEPNERIGQFVLNKIEQIEFVEVEELDSTERGESGFGHTGK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: DAPE_BUCCC
Sequence: MHTNVLNLSKKLINISSISPRDLGCQEILIKRLQLLGFFIERINLKDTKNFWAYRGKGKTVTFLGHTDVVPAGSTRKWKTSPFVATIKDGKLFGRGSADMKGSIAAMLIAVENFIKKFPNHKGRISFLITSDEETSGKNGIRKVVSILKEKKEVIDFCLVGEPTSEKILGDCVKNGRRGSLSADLMIYGTQGHIAYPKLFLNPIHNSIPFLLDLSNLIFDKGNLFFEPTSIQISKIFSEKNCTLNMIPGELRVFFNIRFNTLVNKKKIIRIVENLLNKYLIKYSIFWTYHAKPFLSSSNFLLNLLTKCIYKHTNIIPKIKNNGGTSDARFIFNLTDKIIEFGLPNLTIHKVNEYVYINDLLKLQNIYYSFLEKLLL
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: END4_MYCTO
Sequence: MLIGSHVSPTDPLAAAEAEGADVVQIFLGNPQSWKAPKPRDDAAALKAATLPIYVHAPYLINLASANNRVRIPSRKILQETCAAAADIGAAAVIVHGGHVADDNDIDKGFQRWRKALDRLETEVPVYLENTAGGDHAMARRFDTIARLWDVIGDTGIGFCLDTCHTWAAGEALTDAVDRIKAITGRIDLVHCNDSRDEAGSGRDRHANLGSGQIDPDLLVAAVKAAGAPVICETADQGRKDDIAFLRERTGS
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: SPIKE_BRV1
Sequence: MFLCFCTAPILCLWINSGGAVVVSNESLVVCEPVSYPYSLQVLRSFSQRVNLRTKRAVTTDAWSFAYQISTSSLNVNGWYVNFTSPLGWSYPNGKLFGIVLGSDAMMRASVSTFTYDVISYVGQRPNLDCQINDLANGGLESRYSTVRVDNCGNYPCHGGGKPGCSIGHPYMANGVRTRVLLTTQSPGIQYEIYSGQDYAVYQITPYTQYTVTMPSGTSGYCQQTPLYVECGSWTPYRVHAYGCDKATQSCNYTISSDWVVAFKSKASAIILRSQLIVALAQKLSRTVGVNKAVYFWFLKQPYHYLSLVNFSPNYALFSPLCKSLRQQSATYSALSYGSPFFVAQECYNNALYLPDCCLYTLFSILFSWDYQVNYPVNNVLQANETFLQLPTTGYLGQTVSQGRMLNLFKDAIVFLDFYDTKFYRTNDGPGGDIFAVVVKQVPVIAYSAFRIEQQTGYLAVKCNGVIQATLAPHSSRVVLLARHMSMWSIAAANSTTIYCPIYTLTSFVRLDISTSWYFHTLAQPSGPIQQVSMPVLSTGAAGVYMHPMIEHWVTLLAQSSVYQPSMFNMGVNKSVTLTTQLQAYAQVYTAWFLSILYTRLPESRRLTLGAQLTPFIQALLSFKQADIDATDVDTVARYNVLILMWGRKYAAVIYNQLPEWSYPLFKGGVGDSMWFRKKFLVTTKIHQTASHFPFIAGYLDFLDYKYIPKYKDVACPLSTMVPSILQVYETPQLFVIIVQCVSTTYSWYPGLRNPHTIYRSYKLGTICVLVPYSSPTDVYSSFGFFFQSALTIPTVQTTDDILPGCVGFVQDSVFTPCHPSGCPVRNSYDNYIICPGSSASNYTLRNYYRTTTPVTNVPIEEVPLQLEIPTVSLTSYELKQSESVLLQDIEGGIVVDHNTGSIWYPGGQAYDVSFYVSVIIRYAPPKLELPSTLANFTSCLDYICFGNQQCRGEAQTFCTSMDYFEQVFNKSLTSLITALQDLHYVLKLVLPETTLELTEDTRRRRRAVDEFSDTISLLSESFERFMSPASQAYMANMMWWDEAFDGISLPQRTGSILSSAPSLSSISSWHSYSSRTPLISNVKTPKTTFNVKLSMPKLPKASTLSTIGSVLSSGLSIASLGLSIFSIIEDRRVIELTQQQIMALEDQITILAGYTTKNFEEIQSSLNTLGQQVQDFSQTSALSLQQLSNGFEQITQQLDKSIYYVMAVQQYATYMSSLVNQLNELSQAVYKTQDMYITCIHSLQSGVLSPNCITPFQICHLYQVAKNLSSGECQPILSEREISRFYSLPLVTDAMVHNDTYWFSWSIPITCSNILGSVYKVQPGYIVNPHHPTSLQYDVPTHVVTSNAGALIFDEHYCDRYNQVYLCTKSAFDLAEASYLTMLYSNQTDNSSLTFHPAPRPDPCVYLSASALYCYYSDECHQCVIAVGNCTNRTVTYENYTYPIMDPQCRGFDQITISSPIAIGADFTALPSRPPLPLHLSYVNVTFNVTLPNELNWTDLVLDYSFKDKVYEISKNITQLHEQILQVSNWASGWFQRLRDFLYGLIPAWITWLTLGFSLFSILISGVNIILFFEMNGKVKKS
What is the function of this protein?
Mediates the binding of virions to the host cell receptor and is involved in membrane fusion.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the torovirinae spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein.
Protein: NTPP_MYCS2
Sequence: MTRVVLGSASSGRLSVLRNAGIEPLVVVSDVDEDAIIAAHPSAPPDQVVTALASAKAGEVVTRLSHSDAADAVVIGCDSMLLLDGKLCGKPGSVDAAHRQWQTMSGRSADLVTGHCVIRLHDGEIVGNVTESSGTTVHFGTPSPDDLSAYLATGEPLWVAGAFTLDGLGGWFIDRIEGDPSNVIGVSLPVLRALFERLEVSVADLWSANGR
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRXS5_ORYSJ
Sequence: MYQAIPYSSTRPWLRPEPAASVVDVVKVETTTAVAGRGGEAEVVGEEEAAEVRRAVAESPVLVVGRRGCCLIHVVKRLLQGLGVNPAVHEVAGEAALKGVVPAGGEAAALPAVFVGGKLLGGLDRLMAVHISGELVPILKKAGALWL
What is the function of this protein?
May only reduce GSH-thiol disulfides, but not protein disulfides.
What are the official names of this protein?
Monothiol glutaredoxin-S5.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family. CC-type subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PRIB_ESCF3
Sequence: MTNRLVLSGTVCRTPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIVSGHENQAITHSITVGSRITVQGFISCHKAKNGLSKMVLHAEQIELIDSGD
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).  During primosome assembly it facilitates the complex formation between PriA and DnaT.
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: VGLX_BHV1S
Sequence: MPAARTGTLAAVALILLCGAAVLGRPAPDDLCFADVRRTGMAPSRPLGPVLNLAASDLTSRVSVRAVDASRGCALALLDMAETVVPGGPRAADVVDVGWAYQDGDCMVPLAYRQYFNCTGGALPGQNVCAGLSETRIRGGFGTSDYALYGTSLVLRPGLYDRGTYIYFLGYGPDDIYVGSVTLMVGADIHKYPCGLDRGLGVALHHKSGPARPLTEDDATGDWACGCFPAVVEVDVVWGNVSAAELGLADPIDYADEGGEVEVLEDEAGSASGNLPQDDPDPDLADCRTVGLFSESDMFRTARGPESLLIGAVAKDVLTVPLNLPPGRSYEALRNASLECNSRPRETGDAAVVVMSLQEPARLERRPDARATDPEFGLFGLPDDPAVRRGILIGLAIALLVLLFSLVIVLVCACRLARAAKAARRARAATFAKSNPAYEPMLRV
What are the official names of this protein?
Glycoprotein GX.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein G family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NAC26_ARATH
Sequence: MNSFSQVPPGFRFHPTDEELVDYYLRKKVASKRIEIDIIKDVDLYKIEPCDLQELCKIGNEEQSEWYFFSHKDKKYPTGTRTNRATKAGFWKATGRDKAIYIRHSLIGMRKTLVFYKGRAPNGQKSDWIMHEYRLETSENGTPQEEGWVVCRVFKKKLAATVRKMGDYHSSPSQHWYDDQLSFMASEIISSSPRQFLPNHHYNRHHHQQTLPCGLNAFNNNNPNLQCKQELELHYNQMVQHQQQNHHLRESMFLQLPQLESPTSNCNSDNNNNTRNISNLQKSSNISHEEQLQQGNQSFSSLYYDQGVEQMTTDWRVLDKFVASQLSNDEEAAAVVSSSSHQNNVKIDTRNTGYHVIDEGINLPENDSERVVEMGEEYSNAHAASTSSSCQIDL
What is the function of this protein?
Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity).  Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE).  Triggers thickening of secondary walls (PubMed:25148240).
What are the official names of this protein?
NAC domain-containing protein 26, ANAC026, Protein VASCULAR RELATED NAC-DOMAIN 5.
What is the protein family that this protein belongs to?
Belongs to the plant vascular related NAC-domain protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EXOC2_CAEEL
Sequence: MEENAQARERLPPTVTGLSPTEGVPGTQITIRGENLGNDQSDVIMLFICGIDSLWSMKWKSPSKIIARVGAASRGPGEVRIATKSGGKGSSNVKFRVFITQIGPLEESAVWVDETRTVPGREAIRSVPQIQDERDALGLLPSQKRMDQVLLSRDFPDCSGNLRMENFSPQWYLLENHADATIEDLRIAIKNMELSKQNEAKRSEEMHKANLYSLINCVDTLANLHQALEKGENADHFAALKNISKLIKDSKSKAENVFADVLKRKDDADATRNALGVIVRFKFIFFLSSKIEDSMKKGEYITILNDYTRAKSLYADTDVPLFRELMTEIDEKMQVFKEEMKRKLIDTPVSYEEQSKLIKYLKILDPESDPTWDCITSYYVWLEKSLWDMQTQFLEKAKLEDLENQQRINSQNHLITKTNELQNFVTTLVELLLSKLPSFWKLANTYHNSTASPDAIQRLEDINQMLTNIINVSSWLILNALVPKALPDMVLKQYGDQFAKWPTVPADISRSNLQLSLKTTRSLISSLLENQFSLTHVQPLVELCMTARLKLLSDFVDCGVERVALLAHRINWKQDILDRAQQTKTILPDYYENEICECLTRTRDALSISGYPGEACLFSRERFRDTIIDLFVHLITSIKICFDRLFIRQRPQQLAQEPGQKKGNNEITTKKLLIAVGDIEFIIAKTLNNVGKKMQECGVKHVDQIQEKSRAKLSAFRTKMINDCIAMMSSAFEPLIASATYEYLPDDDDISDYAKEMILCSVLQQAELELYAPQLAIECLQQTVSNALDALLLHFSRLNQDTSPLIVTQIVIDLTGLEEALSTYATLAIRVQINTYRAGLVGRFDNQRLQQCLKNMRTTMRMALQSLEQHAENLGDDSHNTSNI
What is the function of this protein?
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
What are the official names of this protein?
Exocyst complex component 2, Exocyst complex component Sec5.
What is the protein family that this protein belongs to?
Belongs to the SEC5 family.
Protein: ACCD1_ROSS1
Sequence: MKDLFRRAPKRFTAARIENQAIPDNMWVKCPSCGDLIYTRQFSDNLKVCKCGYHMRLTAREWLGLLDDGSFVEFDAALASVDALGFVSPRHVYEQKLIESRQQTGLNDALITSSGAINGMLLCLAVTEFEFIGGSMGSAYGERLARVIERAADARLPLLTINASGGARQEEGTLALLQMAKVNMALTRLAAAGQPHIALLVDPCYGGVLASYTSVADVIIAEPGARVGFAGRRVIEQTIRQKLPVHFQTAEFLLDHGMIDMVTPRSELRGVLSTLLRLYRDAFAHTSAAQHVPALTHVQG
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1, ACCase subunit beta 1, Acetyl-CoA carboxylase carboxyltransferase subunit beta 1.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGFM_ECOLI
Sequence: MIEQFFRPDSVEQALELKRRYQDEAVWFAGGSKLNATPTRTDKKIAISLQDLELDWVDWDNGALRIGAMSRLQPLRDARFIPAALREALGFVYSRHVRNQSTIGGEIAARQEESVLLPVLLALDAELVFGNGETLSIEDYLACPCDRLLTEIIIKDPYRTCATRKISRSQAGLTVVTAAVAMTDHDGMRIALDGVASKALRLHDVEKQNLEGNALEQAVANAIFPQEDLRGSVAYKRYITGVLVADLYADCQQAGEEAV
What are the official names of this protein?
Uncharacterized protein YgfM.
Protein: LAS1L_MOUSE
Sequence: MDRVWRAWDGQSFKENQPESPSARGIVVSWLSRAEWEQVTVYLFCDDHKLQQYALNRITVWRSRLGNELPLAVASTADLVRCKLIDAAGTLGTDELRLLYGMALVRFVNLISERKTKCSNLPLKYLAQEVNIPDWIVELRHNLTHKKMPHINECRRGCYFVLNWLQKTYWSRQLEGSLKETWELDEDQLDAEDPEEEEREIIADDVLEEIPEPQDDDKDEELAVEDDANTKGNEEVASHPEPSSRHKELYEKARELLVSYEEEQFKVLEKHRHLLQAIKVWNNLSPRVQCILEELKSISWENRDAVLDAFLDDGFLIPTFEQLAALQIEYEDGQTEVQKGEVTEPNSHKNIDLNEVLVPKPFSQFWQPLLRGLHSQTFTQALLERMFSELSTVGSTGIRPTYILRWTVELIVANTKTGRNARRFSASQWEARKSWRLFNCSATLDWPQVIESCLGSPCWASPQLLQVVFKAMGQVLPDEEQEKLLRVCSIYTQNGENGLAKAIEGSSSSSTGKAPYTLDTLHEDLQPPGTNCESEESIQQKEQGNLKDVKQEEKKENEEEEKEEEEMEEEEEEEEEEKEEEEEEQEQEEHQEEEQEEEEEEENQKVFQDQMEADVEESDDVEEEEEVDDEEEDEDDDYDDDEEEDRMEVGAFSLAQGSSVFENTRTTSRKREALQGSAWQVSSEDVRWGTFPLGRLPGQTEDPAELMLDNYDTMYLLDQPVIEHRLEPQKSKSSTLSLCCGGSNTNSSSSSSSGNMEGLLWNQGQMHGLKAGLQLF
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.  Required for maturation of the 28S rRNA (By similarity).  Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
What are the official names of this protein?
Ribosomal biogenesis protein LAS1L, Protein LAS1 homolog.
What is the protein family that this protein belongs to?
Belongs to the LAS1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Note=Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export (By similarity). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
Protein: SG11A_RAT
Sequence: MKVLLLFAVFFCLVQRNSGDIPPGIRNTVCFMQRGHCRLFMCRSGERKGDICSDPWNRCCVSSSIKNR
What is the function of this protein?
Has antimicrobial activity against E. coli (PubMed:11230693).  Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection (PubMed:11230693).
What are the official names of this protein?
Sperm-associated antigen 11A, Antimicrobial-like protein Bin-1b, EP2 protein.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DH16D_ORYSJ
Sequence: MEYQGQHGGHASSRADEHGNPAVTTGNAPTGMGAGHIQEPAREDKKTDGVLRRSGSSSSSSSSEDDGMGGRRKKGIKEKIKEKLPGGNKGNNQQQQQEHTTTTTGGAYGPQGHDTKIATGAHGGTAATTADAGGEKKGIVDKIKEKLPGQH
What are the official names of this protein?
Dehydrin Rab16D.
What is the protein family that this protein belongs to?
Belongs to the plant dehydrin family.
Protein: MDH_SHEB5
Sequence: MKVAVLGAAGGIGQALALLLKTQLPAGSHLSLYDIAPVTPGVAVDLSHIPTAVEIKGFAGEDPTPALVGADVVLISAGVARKPGMDRSDLFNINAGIVRNLIEKVAATCPTALVGIITNPVNTTVAIAAEVMKKAGVYDKNRLFGITTLDVIRSETFIAELKGLNVADVKVNVIGGHSGVTILPLLSQVEGVTFTDEEVASLTTRIQNAGTEVVEAKAGGGSATLSMGQAACRFGLSLVRGLQGEANIVECAYVDGGSEHAEFFAQPVLLGKNGIEKVLPYGEVSAFEANARDSMLDTLKGDIKLGVDFVK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: DUT_XYLFM
Sequence: MSAAVKPLQIKILDPRLGTVWPLPTYATEASAGLDLRAALDAPMTLVPGDAELLSTGIAIHLVDPSLCAVVLPRSGLGHRHGIVLGNGTGLIDSDYQGPLLVSLWNRGREAFTIEPGDRIAQLVVLPIVRVVLQVVDTFVESGRGAGGFGHTGVR
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: AURKA_CANLF
Sequence: MDKSKENCIAGPVKTAIALGDGPKRVLVTQQVPSQNPLSANSGQAQRVLCPSNSSQRVPPQTQKLVSSHKPAQNLKQKQLQATGVPRPASRSLNNTQKSEQPSSSAPGNNSEKELATKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILAIKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGAVYRELQKLSKFDEQRTATYITELADALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEASTYQETYKRISRVEFTFPDFVPEGARDLISRLLKHNPSQRPTLKDVLEHPWIMANSSKPSSSQKSKDSTSKQS
What is the function of this protein?
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (By similarity).  Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:27926875).  Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity).  Required for initial activation of CDK1 at centrosomes (By similarity).  Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (By similarity).  Regulates KIF2A tubulin depolymerase activity (By similarity).  Important for microtubule formation and/or stabilization (By similarity).  Required for normal axon formation (By similarity).  Plays a role in microtubule remodeling during neurite extension (By similarity).  Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (By similarity).  Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity).  Inhibits cilia outgrowth (PubMed:27926875).  Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity).  Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (By similarity).
What are the official names of this protein?
Aurora kinase A, Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Ipl1- and aurora-related kinase 1, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase Ayk1, Serine/threonine-protein kinase aurora-A.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Protein: RTF2_RAT
Sequence: MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEVLRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKATSHIRSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEEDIIVLNGTKEDVEMLKRRMEERRLRAKLEKKTKKPKTAESASKLGISQDSAGPSKAKAGKSEEADPDPREKKSSLAPRGTASNGSASGKVGKPPCGALKRSIADSEESETYKSIFTSHSSAKRSKEESAHWVTHTSYCF
What is the function of this protein?
Replication termination factor which is a component of the elongating replisome.  Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication.  Might function to facilitate fork pausing at replication fork barriers like the rDNA.  May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion.  Interacts with nascent DNA.
What are the official names of this protein?
Replication termination factor 2, RTF2, Replication termination factor 2 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the rtf2 family.
What are the subcellular locations of this protein?
Chromosome. Note=Localizes at the replication fork.
Protein: RBL_ABISA
Sequence: KASVGFKAGVKDYRLTYYTPEYQTKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEESQFIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAINKAQAETGEIKGHYLNATAGTCEEMMKRAIFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQRNHGMHFRVLAKALRMSGGDHVHAGTVVGKLEGERDVTLGFVDLLRDDFIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVAVEACVQARNEGRDLAREGNEVIREACK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ATPB_STRPN
Sequence: MSSGKIAQVIGPVVDVLFAAGEKLPEINNALVVYKNDERKTKIVLEVALELGDGMVRTIAMESTDGLTRGMEVLDTGRPISVPVGKETLGRVFNVLGDTIDLEAPFTEDAERQPIHKKAPTFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVGKTVLIQELIHNIAQEHGGISVFAGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLVQLGIYPAVDPLASSSRALAPEIVGEEHYAVAAEVKRVLQRYHELQDIIAILGMDELSDEEKTLVARARRIQFFLSQNFNVAEQFTGQPGSYVPVAETVRGFKEILDGKYDHLPEDAFRGVGSIEDVIAKAEKMGF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TEG1_VZVO
Sequence: MFSRFARSFSSDDRTRKSYDGSYQSFNAGERDLPTPTRDWCSISQRITSERVRDGCLIPTPGEALETAVKALSEKTDSLTSPVLQSTERHSVLLGLHHNNVPESLVVSCMSNDVHDGFMQRYMETIQRCLDDLKLSGDGLWWVYENTYWQYLKYTTGAEVPVTSEKVNKKSKSTVLLFSSVVANKPISRHPFKSKVINSDYRGICQELREALGAVQKYMYFMRPDDPTNPSPDTRIRVQEIAAYTATGYGWMLWFLDVVDARVCRHLKLQFRRIRGPRASVIPDDLLRRHLKTGPAVSAGTGVAFILAATTASALTALLRISVLWRKEEWRDGLNGTAAAIVAAVELITLLHHHFQYLINMMLIGYACWGDGGLNDPYILKALRAQGRFLYFAGQLVRTMSTHSWVVLETSTHMWFSRAVAQSILAHGGKPTKYYAQVLAASKRYTPLHLRRISEPSSVSDQPYIRFNRLGSPIGTGIGNLECVCLTGNYLSDDVNASSHVINTEAPLNSIAPDTNRQRTSRVLVRPDTGLDVTVRKNHCLDIGHTDGSPVDPTYPDHYTRIKAEYEGPVRDESNTMFDQRSDLRHIETQASLNDHVYENIPPKEVGFNSSSDLDVDSLNGYTSGDMHTDDDLSPDFIPNDVPVRCKTTVTFRKNTPKSHH
What is the function of this protein?
Plays a role in the activation of the host PI3K/AKT pathway to promote cell survival.  Interacts with and activates PI3KR1 in order to phosphorylate host AKT on its activating residues.  Activates the host AP-1 pathway by triggering phosphorylation of host ERK1/2.  Participates in host BIM and BAD phosphorylation, leading to apoptosis inhibition.
What are the official names of this protein?
Tegument protein UL46 homolog, Tegument protein VP11/12 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HHV-1 VP11/12 protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host membrane; Multi-pass membrane protein.
Protein: G3P_OMPOL
Sequence: MVVKVGINGFGRIGRLVIRNALEAQGVEVVAVNDPFIPLDYMVYMFKFDSVHGRYKGTVEAKDGKLIIAGKPIAVFGERDPASIPWGASGADYVVESTGVFTTIDKASAHLKGGAKKVIISAPSADAPMYVCGVNLDAYDPRRPSISNASCTTNCLAPLAKVIHDKFGIVEGLMSTIHATTATQKTVDGPSNKDWRGGRSVNNNIIPSSTGAAKAVGKVIPSLNGKLTGLSFRVPTLDVSVVDLVVRLEKEATYDEIKAAVKEAVAGPLKGILDYTEDALVSTDFTGNTHSSIFDASAGIALNKNFVKLIAWYDNEWGYSRRVVDLITFVAQKDGNA
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.