PharMolix/UniProtQA huggingface dataset:
Protein: MDTD_SHIFL
Sequence: MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLAIAGLVAVGVVALVLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQHISVDSGTTQTVFMYTWLSMAFIIALPAFIFARVPNDTHQNVAISRRKRSAQ
What are the official names of this protein?
Putative multidrug resistance protein MdtD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EAR1_YEAST
Sequence: MSFKFLIESLLLGSISGQIRCGRSSVIPRGDVSYGGDDTDELNMDIMLFAFGTLIVVYIVICIVYFFTKQIATRLITAYYNEHGPGQRISLFSDYDENNAHVHSRRLMENMSLRWPNNLDDADEVRDKLAQLSPEEQFYYKQGEEYIKQNPPFLLNQGLLQQSEDSNPDTTREDPIMNEQTRQYIQEEGAYAWEFSPNPDMPNHTVIVENKTEVSFLNYNYDASISTNLPIPCINKVYYCEFKIFETDGPLNSDENVSKGVISFGLSTQPYPYFRLPGRHHHSIAYDSNGARRFNDSFKLNEQLRTLFPQCEKGDIVGIGYRSRSGTVFFTRNGKKLNEKSVGGHIRGWKFQYLYPIIGSNVPCQIHVNFGTYGFVYIEANVKKWGYAKSNGIKLPPPSYEDYGKDTLLESGGEDNDFDEDFSDGDSDNIAAGSTTNLNDDIIIRNGEILPPPPGFEFTMSPPTGKKIINEEINLDSLPMLPPSYSDDEHHSKNDKSAISGRIIGTSRNLITDEASFDSVDNDNEDENDHERDPEQFSEFDDYESRMHGI
What is the function of this protein?
Components of the endosome-vacuole trafficking pathway that regulates nutrient transport.  May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity).
What are the official names of this protein?
Protein EAR1, Endosomal adapter of RSP5.
What is the protein family that this protein belongs to?
Belongs to the SSH4 family.
What are the subcellular locations of this protein?
Endosome membrane; Single-pass type II membrane protein. Vacuole membrane; Single-pass type II membrane protein.
Protein: CCA_NEIMF
Sequence: MQTYLVGGAVRDYLLGLPVKDRDWVVVGADAQTMLAQGFQPVGKDFPVFLHPETHEEYTLARTERKTAKGYVGFSFHADKDVTLEQDLMRRDLTINAMAQDADGKIIDPFGGQRDLAAGILRHVSPAFAEDPVRILRTARFAARYRFEIAEETIKLMRQMVENGEADALVAERVWQEFAKGLMEKNPRKMIEVLRECGALKVLLPEVNALFGVPQRADYHPEIDSGIHTLMTLQRAADMGLSLPERYAALLHDLGKAKTPSDILPRHHGHDLAGVEPVREVNQRLRAPKHCAELAELVCRWHIIFHQVGQLKSQTILNVLKKTDAFRRPERFQTALNVCIADTQGRLNREHTPYPQRAHWFALLEAANQADSGKIAAECRAQGKAHLIAEQIDRARLAQIAPLQKTFRAAQDKTEKH
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: Y102_OSHVF
Sequence: MTNRYHPYRGRELLNSAIDHVVGRWNDADDVNKELEKLRADVDTYKTKFRNLELTRNATDTINVNITHAVEPTETEQTPGVVPQPTTVLSTSIEDYDRSGNEYRRLIGSLKYDDIVKSIYALRERMVYDRDALLERARTQFANPGFLEITSSHIQDALGNTQYKDWKMDTTIKIFSIAKHRIYAHMNREVRLIQQEPEPIDARLKFITTIYPSFWFKELIERGLQEDYNDVLYVEQKNLSLIDGANRSELAKAQSWAPDIHYLISRMCSSLCMVPFIPLTGNNMNHAVYTDTQLLIHYAAFSNPSLVNYKEMLKDEFAYVRDHKSALFRAFETTCIKFKKYKDKLAYKRQGTVVAPTAVNINGTPVEGARGPTPVPPEIMDNLLPFLIDNIIRYRAEQREEAARGSRSIMIERDSPIGRFINFNNKSARELESLVKKLTRDYAMSEREVSLKGLSGQELPVLDFTRTLFTQMMTAAMTCNLMANRYTFFDRVINLVDETTPTPRKDVLYTPSLAAFPGALFYTLMYDQRHPLTPGTSNSSASPYNIAEYATDPVRRNLYSWMKNFFRLVPGIKASKMNTKVYGLAGKYKPNSMPSCEGPGNPSDIKEMMKGLRFINLDTMIQFSNNNKQACNMVLADYLTKIQKTELIEDLSDFYGYMFDLTPPSQGVKLIKNDQFVLPDFNAGNFARFSSAPIAYYIETIKIEERETQRENYRSSYRSDEGFTSLFAGLLEQQQRPRVAAAAPPPPPQPPAAAVPTTQAST
What are the official names of this protein?
Uncharacterized protein ORF102.
Protein: FUCI_SHIFL
Sequence: MKKISLPKIGIRPVIDGRRMGVRESLEEQTMNMAKATAALLTEKLRHACGAAVECVISDTCIAGMAEAAACEEKFSSQNVGLTITVTPCWCYGSETIDMDPTRPKAIWGFNGTERPGAVYLAAALAAHSQKGIPAFSIYGHDVQDADDTSIPADVEEKLLRFARAGLAVASMKGKSYLSLGGVSMGIAGSIVDHNFFESWLGMKVQAVDMTELRRRIDQKIYDEAELEMALAWADKNFRYGEDENNKQYQRNAEQSRAVLRESLLMAMCIRDMMQGNSKLADIGRVEESLGYNAIAAGFQGQRHWTDQYPNGDTAEAILNSSFDWNGVREPFVVATENDSLNGVAMLMGHQLTGTAQVFADVRTYWSPEAIERVTGHKLDGLAEHGIIHLINSGSAALDGSCKQRDSEGNPTMKPHWEISQQEADACLAATEWCPAIHEYFRGGGYSSRFLTEGGVPFTMTRVNIIKGLGPVLQIAEGWSVELPKDVHDILNKRTNSTWPTTWFAPRLTGKGPFTDVYSVMANWGANHGVLTIGHVGADFITLASMLRIPVCMHNVEETKVYRPSAWAAHGMDIEGQDYRACQNYGPLYKR
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
What are the official names of this protein?
L-fucose isomerase, 6-deoxy-L-galactose isomerase, FucIase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTB_ALIF1
Sequence: MKTVESNFDGLVGPTHNYSGLSVGNIASKSNQSGVSNPKQAVKQGLEKMKALHDMGFVQGVLAPQERPDIHTLRRLGFSGSDSEVLKKSYQYSPQLLAACSSASSMWTANAGTVSPSADTADGKVHFTPANLINKFHRSIEDQVTGNILKATFSDEEHFVHHQALPHSDYFGDEGAANHTRFCREYGEQGVEFFVFGKSAFNESYLAPKKYPARQTLEASEAIARTHGLREQFTVFAQQNPDVIDQGVFHNDVIAVGNKNTLFCHQQAFLNQEKVKSDLSDSYGSGFNVIEVPTDKVSVQDAVETYLFNSQLITKADGTTLIILPEHCRQNSRVWAYLNELVEQKCGIDELHTFDLKQSMQNGGGPACLRLRVVLNEAEQKAVNQHTLMSEELFTTLNLWADKHYRDRIEDKDLADPQLLVESRAALDELTQIMHLGSIYPFQK
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: KHSE_NITHX
Sequence: MAVYTDVAADELADFLKAYDIGELLSYKGIAEGVENSNYLLHTTAGSFFLTLYEKRVAVDDLPFFLGLMGHLATHGIVCPQPVKARNGEALGCLAGRPAAIIDFLEGVWPRKPNVTHCAAVGAALAKLHLAGRDFPMRRANALSVSSWRPLFEQATPCIDTVQHGLHDFLKAELDHLERHWPQNLPAGVIHADLFPDNVLFLGDRLSGLIDFYFACNDFFAYDVAICLNAWCFEPDHSFNVTKARALLGAYNRERALSEAEQAALPLLARGAALRFLLTRLVDFLNVPAGALVKPKDPLEYVRKLRFQQSVGNIREYGVAASGLVA
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: GLYA_GLOC7
Sequence: MTDTNLDFLAMSDPAIAEMIQQELQRQRDHLELIASENFTSAAVLAAQGSVLTNKYAEGLPKKRYYGGCEYIDKVEQLAIDRAKQLFGAAHANVQPHSGAQANFAVFLALLEPGDTIMGMDLSHGGHLTHGSPVNVSGKWFRVVNYGVNRETEQLDYDLIREIALKEQPKLIICGYSAYPRIIQFDKFRAIADEVGAYLLADIAHIAGLVATGHHPSPIPHCHVVTTTTHKTLRGPRGGLILTADAELGKKFDKAVFPGTQGGPLEQVIAGKAVAFGEALKPEFKTYSGQVIANAQALANGLIKRGFKIVSNGTENHLMLVDLRSIGMTGKQADQLVSEVNITANKNTLPFDPESPFVTSGLRLGSPAMTTRGMKEAEFIEIANIIADRLLNPEDEAVKQDVKNRVAALCDRFPLYPHLNIPVAAIA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP6_ROTJ1
Sequence: MDLIETINAVVELQHRVRNLSPNTNIYQDGQTTINDYNAIASRCNGKVYNLRDQIAQLSPFQVHMPVIPISTILSTDDHETMSAGIESLFDVLAAAIRTEGSRQNRAVVTKSIEPEVLKAVLDIGIRSQFSENPYANMLQVDTAKMEQQLEPIDDPLASQRINMLAAGGATNNTGGGYHALVGRATGKTGIITIIQGRPGAVTFNLNMKVPCSGVLSLTLLPAPGVIQLSLGNQPPNNIPVHAECVDVSTVFTEGDIVIRFELAGRVVGNANKLGTLNFPLCDRISITIEPWNANKQNNANANFNNWPAGTAQRQPTISLFVNIINASSLIDYETHSKYLAGATYLMGTTFSEDSFIASPPNVVWTMSSLLSGAPPQYIHWTRKIACMIAAFSCKI
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices.  This capsid constitutes the middle concentric layer of the viral mature particle.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes.  VP6 is required for the transcription activity of the DLP.
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: PPK2_TYRGL
Sequence: SPPFAPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-2, PK-2, FXPRL-amide.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYM1_CANAL
Sequence: MKYIFNRYNALLLRRPLITNMITTGLLVGGGDALAQFFFPNNDNNNLEQQPFDYLRNLRAIIYGSLIFAPIGDKWYKFLNTKVVWTRNAQKPQYQRSMSTLLRVMVDQLVFAPFIGIPLYYSSMTILENRQPFLDNIIDKFNTSWWITLKSNWLVWPLFQFFNFYLLPVQFRLLAVNIISIGWNTYLSYVMHSQK
What is the function of this protein?
May be involved in cellular response to stress.  Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).
What are the official names of this protein?
Protein SYM1.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal membrane protein PXMP2/4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VNS1_AQRVC
Sequence: MARRITLNSLKPLSAMSNHPSLTPTTTPTAATASTSTAPSIDSSTAPSLPSTFNQMIFEFNGVKYTGAPHAWMMPYRGFEQHMVNMVIETRPDATFSRFDDLLSAIVTALAVNGITATTSLTDGELVLLRFADLATRHASLPSPSPAISDWSQSVPGPLLDTLEYGAPLIPAEPTATPAPTPLAPADYPPPPPHVADPAVSHSLVALDVPDAALPSMPRASTSTASIPSLMSLPIASPPRSRSSTLSSSTSTSTPRLPGTVVPRRPSHIADDETYNRSRAAYAMGVPAMSPMYCTGKERHFEQTFYSAYPHAANGVWTAYQHSIILIAAPTEDISLLTLHNVEREQSATEAYHLRALDGATVARVAVFRLAPTMTCHDVHAMMAGHNVVSISGLAAAFMIRHKLTDGVFSKSFRRIVMGIDPVMMRHDPVPLHLFAILTDHRLDHAATHAVMSMRLALMQIESASYQATKAWLRGHLPVTIFASATTDSSSDSIHATILEADKGMRVADTPGSSTLRELEASNTALQRQVIDMDVQINALLRTISDLKSYTNHQQASHGYSIQQYLHSHTCVNTQELPLIQSVMGDQAANAIQAMRTHANEAARSALTDKVTAPLTAQLSDTMAHLHEARAHNGDLTAQLAIAETDAMTAANERDRACELAVELESQLATMQREYDQTTRALLQDNEQLQHSAATAEAAAVSAFRPTPPLTYGTAPSALPAVGPGLTVPLLAAAIDPASLLL
What is the function of this protein?
Non-structural protein with ssRNA-binding activity.  Is probably involved in the formation of viral inclusions, where the assembly of cores and the replication of viral RNA are thought to occur (By similarity).
What are the official names of this protein?
Non-structural protein 1, NS1.
What is the protein family that this protein belongs to?
Belongs to the aquareoviridae NS1 protein family.
Protein: SASG_PRIMG
Sequence: MAKQTNKTASGTSTQHVKQQNAQASKNNFGTEFGSETNVQEVKQQNAQAAANKSQNAQASKNNFGTEFASETSAQEVRQQNAQAQAKKNQNSGKYQG
What is the function of this protein?
SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism.  These proteins may be involved in dormant spore's high resistance to UV light.
What are the official names of this protein?
Small, acid-soluble spore protein gamma-type, SASP.
What is the protein family that this protein belongs to?
Belongs to the gamma-type SASP family.
Protein: F16PA_CHLL3
Sequence: MSQLITIERHILEQQKNFPEATGELTDLLSDVAFAAKLVRREVVRAGLVDILGFAGSTNVQGEEVKKLDLFANDKIINAIGQHGRFAIMGSEENEGIIIPPKNETGSYALLFDPLDGSSNIDVNVSVGTIFSIYRIKSSDPGNASISDCLQKGSEQVAAGYVIYGSSVVMVYTTGHGVHGFTYDPTIGEFLLSHENITTPGSGKYYSINEGSYAQFNDGTKRYLDYIKEEDPATGRPYSTRYIGSLVADFHRNLLTGGVFVYPPTTKHPSGKLRLMYEANPLAFICEQAGGRATDGHRRILDIDPSELHQRTPLYIGSMADVKVAEEFEQGIR
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP152_IXORI
Sequence: MESFVAMKVVCIVLLFVIAAEAASTGKNPVGDAPNGKKNNITFNFPPYVPNHHAFASSLWKLCEESTPKPEMKIVDSRTTYTRRINDLQVNFKDCTFLCKRRFDNVTLDLPKNTPCGPKNQTCENKDQCVPHIPGC
What is the function of this protein?
Salivary tick protein that downregulates host immune system by binding to both dendritic cells, and CD4(+) T cells.  Specifically binds to the CD4 coreceptor on T cells.  This interaction prevents the activation of the Src kinase, Lck, and its downstreamsubstrate Zap-70, and results in deficient activation of PLCgamma1, the repression of calcium fluxes triggered by T-cell antigen receptor (TCR) ligation, and a subsequent reduction in interleukin-2 production.  This salivary protein also binds to DC-SIGN (CD209) on dendritic cells (DC) and activates the Raf-1 kinase/MEK signaling pathway that results in down-regulating expression of pro-inflammatory cytokines.  Furthermore, it inhibits T cell proliferation induced by DCs (By similarity).  In addition, it inhibits in vitro keratinocyte inflammation induced by Borrelia burgdorferi or by the major outer surface protein (OspC) of Borrelia (By similarity).  In addition, it downregulates chemokines and monocyte chemoattractant protein 1, as well as several antimicrobial peptides such as defensins, cathelicidin, psoriasin, and RNase 7 (By similarity).  Apart from its immunomodulatory activities, it is also associated with protection of Borrelia spirochetes from antibody-mediated killing through its binding to OspC (By similarity) (PubMed:33401196).  In vivo, tests on different immune disease animal models show promising therapeutic results, e. g. , in inhibiting HIV infection, experimental autoimmune encephalomyelitis, transplantation rejection, and asthma (By similarity).
What are the official names of this protein?
Salivary protein 15 Iric-2, Salp15 Iric-2, Salp15-like.
What is the protein family that this protein belongs to?
Belongs to the salp15 family.
Protein: MNTP_ECOUT
Sequence: MNITATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGMGMLASRFVLEWNHWIAFVLLIFLGGRMIIEGFRGADDEDEEPRRRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGSIIGKKAEILGGLVLIGIGVQILWTHFHG
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Probable manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GSPE_PSEAE
Sequence: MMTAPLPDIAAPAAPPRRLPFSFAKRQGLLFLCLEEQYWLACRPQVELAAIAEAQRFAGRRLPLKALGEDAFNQALAASYQHDSSAAMQLAEDLGGSLDLAALADQVPETEDLMEQEDDAPIIRLINAILGEAIRENASDIHLETFEKRLVVRFRVDGVLREVLEPKRELAALLVSRIKVMARLDIAEKRIPQDGRISLRVGGREVDIRVSTLPSANGERVVLRLLDKQAGRLNLQHLGMSERDRKLMDETVRKPHGILLVTGPTGSGKTTTLYASLTTLNDRTRNILTVEDPIEYHLEGIGQTQVNAKVDMTFARGLRAILRQDPDVVMVGEIRDRETAEIAVQASLTGHLVLSTLHTNSAIGAITRLVDMGIEPFLLSSSMLGVLAQRLVRVLCPACKEPYRADEAECALLGVDPAAPPTLHRARGCGECHQHGYRGRTGIYELVVFDDHMRSLIHNESSEQEMTRHARTSGPSIRDDGRRKVLEGVTTVEEVLRVTREE
What is the function of this protein?
ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
What are the official names of this protein?
Type II secretion system protein E, T2SS protein E, General secretion pathway protein E, Protein-secreting ATPase, Type II traffic warden ATPase.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
What are the subcellular locations of this protein?
Cell inner membrane. Note=Membrane association is not an intrinsic property but requires the XcpY/GspL gene product.
Protein: IF4A3_NICPL
Sequence: MEEDRLVFETSKGVEPIASFAEMGIKDDLLRGVYQYGFEKPSAIQQRAVLPIISGRDVIAQAQSGTGKTSMIALTVCQIVDTKSSEVQALILSPTRELAAQTEKVILAIGDYINVQAHACIGGKSVGEDIRKLEHGVQVVSGTPGRVCDMIKRRTLRTRGIKLLILDESDEMLSRGFKDQIYDVYRYLPPELQVVLISATLPNEILEITSKFMTDPVRILVKRDELTLEGIKQFFVAVEKEEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTSKMRENNFTVSSMHGDMPQKERDAIMAEFRGGTTRVLITTDVWARGLDVQQVSLVINYDLPNNRELYIHRIGRSGRFGRKGVAINFVKSDDIKILRDIEQYYSTQIDEMPMNVADLI
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
Eukaryotic initiation factor 4A-3, eIF-4A-3, ATP-dependent RNA helicase eIF4A-3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
Protein: 4AD_HETMG
Sequence: ASCKCDDDGPDVRSATFTGTVDFWNCNEGWEKCTAVYTPVASCCRKKK
What is the function of this protein?
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (PubMed:2412579).  Its toxicity is weaker than that of RpIII (AC P08380) (PubMed:2412579).
What are the official names of this protein?
Delta-stichotoxin-Hmg4a, Delta-SHTX-Hmg4a, Delta-stichotoxin-Rpa1a, Delta-SHTX-Rpa1a, RpII, Toxin II.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type II subfamily.
Protein: MUTS_RHOP2
Sequence: MHRVMTIHPDIAPPPDLPAPAEPPAKVSPMMEQYHEIKAANPGLLLFYRMGDFYELFFEDAEIASRALGITLTKRGKHQGMDIPMCGVPVERSDDYLHRLIALGHRVAVCEQTEDPAAARARKSVVRRDVVRLITPGTLTEDTLLDARANNYLLAIARARGSSGTDRIGLAWIDISTGEFSVTECATGELSATLARINPNEAIVSDALYSDAELGPSLRELAAVTPLTRDVFDSATAERRLCDYFAVATMDGLAALSRLEAAAAAACVTYVDRTQLGKRPPLSPPSREATGATMAIDPATRANLELTRTLAGERRGSLLDAIDCTVTAAGSRLLAQRLAAPLTDAAAIARRLDAVEVFVVAPALREQIRSALRAAPDMARALARLSLGRGGPRDLASLRDGIVAADQGLQQLSQLTAPPQEIAAAMAALRRPSRDLCDELGRALADDLPLQKRDGGFVRDGYEAALDETRKLRDASRLVVAAMQARYADDTGVKGLKIRHNNVLGYFVEVTAQHGDRLMAPPLNATFIHRQTLAGQVRFTTAELGEIEAKIANAGDRALGLELEIFDRLAALIETAGEDLRAAAHAFALLDVATALAKLASDDNYVRPEVDQSLSFAIEGGRHPVVEQALKRAGEPFIANACDLSPGPAQASGQIWLLTGPNMAGKSTFLRQNALIALLAQTGSYVPAARARIGIVDRLFSRVGAADDLARGRSTFMVEMVETAAILNQATERALVILDEIGRGTATFDGLSIAWAAIEHLHEQNRCRALFATHYHELTALSAKLPRLFNATVRVKEWRGEVVFLHEVLPGSADRSYGIQVAKLAGLPASVVARAKSVLAKLEANDRGQPKALIDDLPLFAITARAPAEPSPPSEAEQLIAAVQALHPDELSPREALDALYALKAKLPKTT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: DPNP1_ARATH
Sequence: MAYEKELDAAKKAASLAARLCQKVQKALLQSDVQSKSDKSPVTVADYGSQAVVSLVLEKELSSEPFSLVAEEDSGDLRKDGSQDTLERITKLVNDTLATEESFNGSTLSTDDLLRAIDCGTSEGGPNGRHWVLDPIDGTKGFLRGDQYAVALGLLEEGKVVLGVLACPNLPLASIAGNNKNKSSSDEIGCLFFATIGSGTYMQLLDSKSSPVKVQVSSVENPEEASFFESFEGAHSLHDLSSSIANKLGVKAPPVRIDSQAKYGALSRGDGAIYLRFPHKGYREKIWDHVAGAIVVTEAGGIVTDAAGKPLDFSKGKYLDLDTGIIVANEKLMPLLLKAVRDSIAEQEKASAL
What is the function of this protein?
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP.  May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS.  May play a role in the biosynthesis of sulfate conjugates and RNA processing.  Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate.  Could be considered as a negative regulator of abscisic acid (ABA)- and stress-responsive genes, through modulating the inositol 1,4,5-trisphosphate (IP3) turnover.  Is also involved in salt tolerance.  Acts as a suppressor of virus- and transgene-induced silencing.
What are the official names of this protein?
SAL1 phosphatase, 3'(2'),5'-bisphosphate nucleotidase 1, 3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase 1, DPNPase 1, Inositol polyphosphate 1-phosphatase 1, IPPase 1, Inositol-1,4-bisphosphate 1-phosphatase 1, Protein FIERY 1.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
Protein: AC4CH_SHEB9
Sequence: MLLNKITFFERFEHDILSGAKTITLRDEAESHVIVGQILPVSTFETERWFCDIQIIDVTPVKLTELTEVHAKQENMTLPQLRDVIAEIYPGLEQLFMIRFRILSQ
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: DSBD_ECOUT
Sequence: MAQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNEASQPVSVPQQEQPTAQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQHPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFIMGAIAGLICSPCTTAPLSAILLYIAQSGNMWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQVKTAFGFVILALPVFLLERVIGDIWGLRLWSALGVAFFGWAFITSLQAKRGWMRVVQIILLAAALVSVRPLQDWAFGETHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCVACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHLRDRQP
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAPSD_TMOB
Sequence: MPYTVTSPSQLVYFGSVWADPITFIDLCTVALGNQFQTQNARTTVQQQFSDLFKTVPTRTNRFNDGENGFRVFRYNSTLDPLISALMNSFDTRNRIIEVDNPANPNTSEVASATQRVDDATVNIRACINNLMNELVRGTGMMNTASFETVSNLTWTTTTTT
What is the function of this protein?
Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.
What are the official names of this protein?
Capsid protein, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the virgaviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: NUOA_VEREI
Sequence: MNLDQYLPVLLFILVGIAVGVVPLVLGYVLGPNRPDAAKNSPYECGFEAFDDARMKFDVRYYLVAILFILFDLEIAFLFPWAVTLQQVGMAGFVAVLIFLTILVVGFAYEWKKGALDWE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.