PharMolix/UniProtQA huggingface dataset:
Protein: GUNB_CELFI
Sequence: MLRQVPRTLVAGGSALAVAVGVLVAPLATGAAAAPTYNYAEALQKSMFFYQAQRSGDLPADFPVSWRGDSGLTDGADVGKDLTGGWYDAGDHVKFGFPMAFSATMLAWGAIESPTGYSKAGSLDELKDNLRFVSDYFVKAHTAPNELYVQVGDGEADHKWWGPAEVMTMARPSHKISASCPGSDVAAETAAALASSAIVLKGDDPAYAATLVSHAKQLYTFADTYRGAYSDCVTAASAYYKSWSGYQDELVWGAYWLYKATGDATYLAKAEAEYDKLGTENQSTTRSYKWTIAWDNKQFGTYALLAMETGKQKYVDDANRWLDYWTVGVNGQKVPYSPGGQAVLDSWGALRYAANTSFVALVYSDWMTDATRKARYHDFGVRQINYALGDNPRSSSYVVGFGANPPTAPHHRTAHGSWLDSITTPAQSRHVLYGALVGGPGSPNDAYTDSRQDYVANEVATDYNAGFTSALARLVEEYGGTPLASFPTPEQPDGDQLFVEAMLNQPPSGTFTEVKAMIRNQSAFPARSLKNAKVRYWFTTDGFAASDVTLSANYSECGAQSGKGVSAGGTLGYVELSCVGQDIHPGGQSQHRREIQFRLTGPAGWNPANDPSYTGLTQTALAKASAITLYDGSTLVWGKEPTGTTTDTTPPTTPGTPVATGVTTVGASLSWAASTDAGSGVAGYELYRVQGTTQTLVGTTTAAAYILRDLTPGTAYSYVVKAKDVAGNVSAASAAVTFTTDTTGETEPPTTPGTPVASAVTSTGATLAWAPSTGDPAVSGYDVLRVQGTTTTVVAQTTVPTVTLSGLTPSTAYTYAVRAKNVAGDVSALSAPVTFTTAAPPVDTVAPTVPGTPVASNVATTGATLTWTASTDSGGSGLAGYEVLRVSGTTQTLVASPTTATVALAGLTPATAYSYVVRAKDGAGNVSAVSSPVTFTTLPVTSTPSCTVVYSTNSWNVGFTGSVKITNTGTTPLTWTLGFAFPSGQQVTQGWSATWSQTGTTVTATGLSWNATLQPGQSTDIGFNGSHPGTNTNPASFTVNGEVCG
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
Endoglucanase B, Cellulase B, Endo-1,4-beta-glucanase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 9 (cellulase E) family.
Protein: VKT2P_HETCR
Sequence: GSICLEPKVVGPCTAYFRRFYYDSETGKCTPFIHGGCEGNGNNFETLRACRAICRA
What is the function of this protein?
This recombinant serine protease inhibitor inhibits trypsin (Ki=100 nM) (Ref. 3).  It may also inhibit the TRPV1 receptor of the pain pathway (By similarity).  It possesses anti-inflammatory activity in vitro (Ref. 3).  It blocks histamine influence on intracellular calcium concentration in murine bone marrow-derived macrophages (84% inhibition at 10 uM and 67. 2% at 1 uM), which can indicate inhibition of H1-histamine receptor (HRH1) (Ref. 3).  In vitro, it shows cytoprotective activity in the oxidative stress agent 6-hydroxydopamine (6-OHDA)-induced neurotoxicity model (PubMed:33802055).  In this model, it decreases reactive oxygen species (ROS) level, and increases cell viability in a correlated manner (PubMed:33802055).  In vivo, it shows analgesic activity, since it increases hot plate and tail flick withdrawal latencies, when using a mice thermal pain stimulation model (PubMed:25937220).
What are the official names of this protein?
PI-stichotoxin-Hcr2p, PI-SHTX-Hcr2p, Kunitz-type serine protease inhibitor HCGS1.36.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: G6PI_ECO55
Sequence: MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_PROM9
Sequence: MSSSALQVAKTGTYLPDLVEVQRASFKWFLEKGLIEELQNFSPISDYTGKLELHFIGEEYRLKRPRHDVEEAKRRDATFASQMYVTCRLINKETGEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDKNGRRTYNASVIPNRGAWLKFETDKNNLLYVRVDKTRKINAHVLMRAMGLSDNDVVDKLRHPEFYQNSIESANDEGINSEDQALLELYKKLRPGEPPSVSGGQQLLFSRFFDPKRYDLGRVGRYKINKKLRLTVPDDVRTLTHEDVLSTIDYLINLELDIGGASLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATHARVNEYGFIETPFWKVNNGKVNKDGDPIYLSADLEDECRVAPGDVATDKDGNILANLIPVRYRQDFEKVPPEQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVGTGLESQVARDSGMVPITKVNGTVSYVDANEIVVKGEDGNEHFHYLQKYQRSNQDTCLNQRPIVNIGDQVISGQVLADGSACEGGEIALGQNVLIAYMPWEGYNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNISEDSLNNLDEMGIIRIGAFVESGDILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTREQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFDEMYGAEKSHQTVQAFLEEASKQPGKAWIYNPEDPGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSLGLDIGVYTDEGKEVDLMQDINPRRNTPSRPTYESLGTSEYEED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RL9_MESH7
Sequence: MKVILIKDTKDGKANTIIDVSPGYATNFLFKNKLAEPLNSRTEKLLVKRKQQIEIEKQEKQEQIAKLKIEIEKLVLWFKLKGNKESVHGAITAKKIKKELEIKGIFVDKQAIQTSGISTFGTSFVDIKLSSQTIAKLKINITKDE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: AROB_ZYMMO
Sequence: MSSEVSKTVTVPIDLGNHSYKIDIGAGLYQQAVSILTPYVRNRRFIVITDENVARCQLPEFEKSFHEAGVTVDSIILPAGEATKSWHHLAELCDQLIRRGVERRDAIIALGGGVIGDLVGFAAAILKRGCQFIQIPTSLLAQVDSSVGGKTAINCEAGKNLIGAFHQPVFVLIDPDALQTLPARQLRAGYGEIIKYGLIDDPDFFAWCEEHGAALIEGDKASRLYAIEHSIRAKALIVADDEKEISGKRALLNLGHTFGHALEADTGFSDKLFHGEAVAAGSALAFGFSYVKNLASKEDIQRIIKHLRETGLPASLEEAGVKASGKELVAHMMHDKKMEAGRLPFLLARGIGKSFLDKEVNLEEIAAFLDSPLARKGTI
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_ECO55
Sequence: MTLTASSSSRAVTNSPVVVALDYHNRDDALSFVDKIDPRDCRLKVGKEMFTLFGPQFVRELQQRGFDIFLDLKFHDIPNTAAHAVAAAADLGVWMVNVHASGGARMMTAAREALVPFGKDAPLLIAVTVLTSMEASDLVDLGMTLSPADYAERLAALTQKCGLDGVVCSAQEAVRFKQVFGQEFKLVTPGIRPQGSEAGDQRRIMTPEQALSAGVDYMVIGRPVTQSVDPAQTLKAINASLQRSA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: OTP_HELTB
Sequence: MERTLAHVPSMELSTEALLVTGGLDNTNKMITSSAVRNDDGTMISQHSEKVSYGTSGAPDGSTPPVTAAGGGSEGNGIGGGGGGGGGGGMVGDGTGHSVGSSGSGNDDDKPAKQKRHRTRFTPAQLNELERNFAKTHYPDIFMREEIAMRVGLTESRVQVWFQNRRAKWKKRKKTTNVFRTPGALLPSHGLAQFPSPMNDSFCNFHGQDTRGWPAMSGMTTHMAPHMTTHMPSHQMSQMGGGPGSALALPPSLPRQGLGQTMQQQSVNCSMGQTTGLNTLSMGTNGSMGSMTSMYQPSLGGMTTGSMSSGLSSPSPPNLPVTDSSTDLSCSVSDAGDMWRGTSIASLRRKALEHAASLNGIFR
What is the function of this protein?
Involved in larval skeletal patterning.
What are the official names of this protein?
Homeobox protein orthopedia.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL14_PHEZH
Sequence: MIQMQTNLDVADNSGARRVMCIKVLGGAKRRYAGVGDKIVVSVKEAIPRGRVKKGDVLQAIVVRTSQGIKRKDGSVIRFDKNAAVIVNKQSEPIGTRIFGPVPRELRAKNHMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: YO21A_YEAST
Sequence: MESQQLSQNSPTFHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIGSQDQHSEVPQAKTKVRNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYSDILTVLCKSVSKMQTNNQELKDWIALANLEYNGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYHRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLRPATERI
What is the function of this protein?
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.  The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules.  CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
What are the official names of this protein?
Transposon Ty2-OR1 Gag polyprotein, TY2A, TYA, Transposon Ty2 protein A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOC2B_DROER
Sequence: MDHVKLVNDPIDIAHIHQLLADAGCGASSVFVGTTRDNFQGKKVVSLAYEAYDSMALKEMNKICLDLRSKWPDLKHIVIYHRLGTVPVCEASVVIAASSPHRSEALESVSFAIDQLKTRVPIWKKEIYEGDHVSEWKENKESIRPKRSKSAFNYAACPCKVEESHDVPRTLVQIRVNDAELTKRLECFVNRKRDEINSQNVIDFKSSFVNSDIDLSDSCARTQSTIIKQEQSNCHLKVRRVNNRCGPQQMEMRPNYELELNKLMGSRDGQTDPFKEMRKSLPNSRLQAIESYMCLTTDNEENIFSRIKKVENRLLQLESISPEYRHFTKLEPSSMELPPPKKIRKKSYSVPELSAFIQKIKEGSEFA
What is the function of this protein?
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin.  Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated Mocs2A into precursor Z to generate a dithiolene group.
What are the official names of this protein?
Molybdopterin synthase catalytic subunit, Molybdenum cofactor synthesis protein 2 large subunit, Molybdenum cofactor synthesis protein 2B, MOCS2B.
What is the protein family that this protein belongs to?
Belongs to the MoaE family. MOCS2B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1466_PASMU
Sequence: MTKVIHTDNAPAAIGPYVQAVDLGNMLLTSGQIPVNPKTGEVPADIVAQARQSLENVKAIVEQAGLQVANIVKTTVFVKDLNDFAAVNAEYERFFKENNHPSFPARSCVEVARLPKDVGIEIEAIAVKA
What are the official names of this protein?
RutC family protein PM1466.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: ALCC_WHEAT
Sequence: SFREQCVPGREITYECLNACAEYAVRQ
What are the official names of this protein?
Allergen C-C.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I6 (cereal trypsin/alpha-amylase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBE_CHAVU
Sequence: MSGNTGERPFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGTPRPNEYFTENRQEVPLITDRFNSLEQIESYTKSI
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: AMPA_LEGPL
Sequence: MNYGLTHTPSLNMSECLVLGVFSDLALPDFATAIDNEQQGLIKKLCQRVPEPGNTVWQTDVEGHSLLIIQCGKKEGFSANSLQKRVGEITEALIKQRFSSATVCLPRLNQESSEWQLEQMIVQIDNLRYQLLDFKTKHAKSHKLESVIFHLPGATEKSLEMAKAIVSGVEFCRDLANMPANICTPTYLGEQAISLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQPPRLIDIHYHGNKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIGIIASAENLISGSAVKSGDIVTTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIERAANESQDKVWRMPLDEAYQDALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPVPLLIQLLRHVANSR
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_NITWN
Sequence: MKLSDIADNAGSRKKRMRIGRGIGSGKGKTGGRGGKGQTARSGVRINGFEGGQMPLHRRLPKRGFNNIFRVEFAEINLDRLQDAIDAGSIDANTTINAESLVKSGVVRRAKGGVRLLGRGEIKAKLTVEVHGASKSAIAAVEKAGGTVKILAPKKDEGEAA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PAKF_DICDI
Sequence: MSNLKLSNNNNGNQKESSSFFQKVMKSPSTQNLLNSFSSNNSNNNLSNSGSNEVKDTTTNSPSQLPPNYTPPPPPHQIRNSSSIEGGEFSLLNNENSDNNNNNNNNNNNNNNNNNNNNNNNNNNNEQLARTESSVSIISSSSSGSNSGQPNLQRHSSNISTDDSNTTTETYSMSPNQTLNSNIDSSEQQHQDLSSSVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTHESRKLTRKIAQFISSPKLLQSSISQLPSTPTQQNVEIQTTNGGSSETSPNGLISPRPSNDQPLKEKKKKKFLKTPEIFKHHHHHKESSLSSSTTTPSTTSSLTSSPSSSSLAISSPNTTAATTTNKKSHKKTKSTFDINTEISVPYNVIHKMHVDFDLKWTGHNDFILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESESVSLQNEINILKNCKSPNIVSYFGSLQTESHIWILLDFCALGSIRDIIESTEKTLNEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNGALDQSKEMIGTPLWMAPEVILKKNYDYKADIWSLGITIIEMADGLPPHIDLPPMRAMKMVPNWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFLKKDRGPDVLSDLVNQLFKIKKKKIDDLKKQQKHQTSQSSSSSSPQSPNATVNGGDIGSDGLSTSIISPIPSSPSDELDNCNNSLKLATSSKGMLSFKGNYTTCRDFQEEEEDSKHLNNNQDEQDDEQDDEDDDDENEDDEDVDPFSTTIFHGKKKGSGNGNGGVTSDQDDEEEDEEEDDEEEEEEEEDDDEINEDEEISATGTMVVRKKKNKSTKKSNKKKNKKNNLSTIGKSGSGNNLLHVAPNKPLPITPPFSISMTNEFKQLETKLFTYIDSSNQKIVNDIKNEIKQLESSIINKININLQQQLSPILLALEEIKQNQHTTSQPKQMQSKLSATNLNEKKLSSSPPSSNSPLTNSVNSSLTTTTTTTTSPVLSRQSSFRSSGSISSSNSSFRPNSAIMSAVNNSSTTTTTNSNSSSSNGGGSGVDISPTMTGRASPSIMKRFTTSSSSSPLSSSSDGFAFNSNSNSSSSDLKRHVITPEELNNSNLVKNKVKMFEDDNSSGSGSNSPSLSTNSSSTNSNNSVTNIKK
What are the official names of this protein?
Serine/threonine-protein kinase pakF.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Protein: RL5_CAEEL
Sequence: MGLVKVIKNKAYFKRYQVKLRRRREGKTDYYARKRLTVQDKNKYNTPKYRLIVRITNKDVVAQLAYSKIEGDVVVASAYSHELPRYGLKVGLTNYAAAYATGLLLARRHLKTIGLDSTYKGHEELTGEDYNVEEEGDRAPFKAVLDIGLARTTTGSKIFAVMKGVADGGINVPHSESRFFGFDQESKEYNAEAHRDRILGKHVADYMTYLKEEDEDRYKRQFSKFLAAGLNADNLVATYQKVHSAIRADASPAAKKAAKPSKRHTAKRLTYDERKQRVADKKALLLQLKEQQE
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TYDC1_PAPSO
Sequence: MGSLPANNFESMSLCSQNPLDPDEFRRQGHMIIDFLADYYKNVEKYPVRTQVDPGYLKKRLPESAPYNPESIETILEDVTNDIIPGLTHWQSPNYFAYFPSSGSIAGFLGEMLSTGFNVVGFNWMSSPAATELESIVMNWLGQMLTLPKSFLFSSDGSSGGGGVLQGTTCEAILCTLTAARDKMLNKIGRENINKLVVYASDQTLSALQKAAQIAGINPKNFLAIATSKATNFGLSPNSLQSTILADIESGLVPLFLCATVGTTSSTAVDPIGPLCAVAKLHGIWVHIDAAYAGSACICPEFRHFIDGVEDADSFSLNAHKWFFTTLDCCCLWVKDSDSLVKALSTSPEYLKNKATDSKQVIDYKDWQIALSRRFRSMKLWLVLRSYGIANLRTFLRSHVKMAKHFQGLIGMDNRFEIVVPRTFAMVCFRLKPAAIFRKKIVEDDHIEAQTNEVNAKLLESVNASGKIYMTHAVVGGVYMIRFAVGATLTEERHVTGAWKVVQEHTDAILGALGEDVC
What is the function of this protein?
Marginally higher substrate specificity for L-DOPA over L-tyrosine.
What are the official names of this protein?
Tyrosine/DOPA decarboxylase 1.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: AROB_BACC3
Sequence: MGNIHIQTKSKEYDVYVGKESLSHLTTIVQNMQPSVSNIMIISDEAVASLHLQTVVDALQIDQKVFSFVVPSGEKEKSFENFYAAHTSALENKLDRNSLIVALGGGMIGDLAGFVAASFMRGIRFVQVPTTLLAHDSAVGGKVAINHPLGKNMIGAFHQPEAVVYHTPFLQSLPEKEWRSGYAEVIKHALIGDVKLYHWLKEEVQTLADLRDEKLIHILTKAIPVKANIVAQDETEKGVRAHLNFGHTLGHALEKELGYGNITHGDGVAVGMLFAIFLSEQVYKVNLAYEEMKQWFLKYGYPKMPSDLSVERLVGLMKQDKKANAGTIHMVLMQEYGVVNVVSIPDETVHIALEAFQKDMVEK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_SALG2
Sequence: MLDPNLLRNEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVNTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDTLLAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEIRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNHDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEVPLTNLVRDEIIDEDQLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWVPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_VIBPA
Sequence: METLLSFSAIAVGIIVGLASLGTAIGFALLGGKFLEGAARQPEMAPMLQVKMFIIAGLLDAVPMIGIVIALLFTFANPFVGQLG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CRTAM_MOUSE
Sequence: MWWGALSLLFWVPVQAAFLKMETVTVEEGQTLTLTCVTSQTKNVSLQWLAPSGFTIFLNQHPALKSSKYQLLHHSATQLSISVSNVTLREEGVYTCLHYGSSVKTKQVRVTVLVTPFQPTVEALVLRRQNGEKSVVLKCSTERSKPPPQITWLLGEGLEIYGELNHEFEADGKICNTSSMLIARAYGKNSTVHCIIQHEGLHGRKLVAPFQFEDLVADQETSDQETSDAPEQSSLSSQALQQPTSTVSMMENSSIPETDKEEKEHATQDPGLSTEASAQHTGLARRKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVVWKKESEISEQALESYRSRSNNEETSSQENSSQAPQSKRCMNYITRLYSGAKTKKSAQHWKLGGKHSRVPESIV
What is the function of this protein?
Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (PubMed:15811952, PubMed:18329370, PubMed:19752223, PubMed:24687959).  Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952).  Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (PubMed:18329370).  Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (PubMed:19752223).  Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (PubMed:18329370).  By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (PubMed:19752223).  Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (PubMed:24687959).  Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (PubMed:24687959).
What are the official names of this protein?
Cytotoxic and regulatory T-cell molecule, Class-I MHC-restricted T-cell-associated molecule.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=In a subset of CD4+ T- cells, colocalizes with SCRIB at the immunological synapse during the late phase of T-cell activation.
Protein: YIDC_WIGBR
Sequence: MVVQNNFLFIAFIFVTFMMLDAWQSESYDYKSLDKNHIIEKKNIENKNINKEVFSRENYITVITDLFILKINTYGGDIEEASLRTYLSNTKNNLPLKILDRSKNFIYKLKSGFITKNDHDINNLIHIPNFISDKKLYILEDNSDYLQVPLFYNGENGLKYVKNFIFKKNSFSLKINYSIKNTNKDKMEMMFFGQLEQSIKDQEINNGYNFNFHTYRGAAYSSDNNKYKKYDFSEISNDKNLNVITSNGWIAMLQQYFIVAWIPKIENKYKFYTKNIPKDEKVSIGFQSELFSIDQEEEKNIESTLWIGPKLQDKMYEVDANLGLTVDYGWLWFIAQPLLQLLKFIYKYINNWGISIIIITFMVRGIMFPLTKAQYTSMAKMRILQPKIIEIKNKFSNDKKRQSKEMMSLYKKQKVNPLGGCMPLIIQMPIFLALYYMLSGSVELRHAHFVLWINDLSSKDPYYILPIIMGITMFLIQKISPSSISDPVQKKIVSFMPLIFTIFFLWFPSGLVLYYIISNLVTIIQQYIIYKDLKKVGILI
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.