PharMolix/UniProtQA huggingface dataset:
Protein: CBPA_PSEP1
Sequence: MDFKDYYKILGVEPTADEKAIKAAYRKLARKYHPDVSKERDAEEKFKEANEAYEVLGDAQKRAEFDEIRKYGGQHGRPFQAPPGWESRGGGGGFEGGDFSDFFSSIFGGRSAGGNPFGGARQQQRSAGRRGQDVELELAVFLEETLSKESKQISFQVPQTNAMGQRTGFTTKTLNVRIPAGVTDGERIRLKGQGAPGSGGGANGDLFLTIRMAPHPLFDVEGHDLIITVPLAPWEAALGAKVAVPTLDGKINLTIRPDSQSGQRLRVPGKGLVNKQGARGNLYAQLKVVMPPASDESARELWTKLSEKAAFNPRTQWSK
What is the function of this protein?
DNA-binding protein that preferentially recognizes a curved DNA sequence.  It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock.  Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK.  Its activity is inhibited by the binding of CbpM.
What are the official names of this protein?
Curved DNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL1_FINM2
Sequence: MAKKGKKYQESAKLIDRTVEYKLDEASKLVVETAKAKFDESVELHAKLGVDSRHADQQVRGTIVLPHGTGKDQKVAVFAKGEKAEEAKAAGADFVGAEDLAEKIQKEGWLGFDVAVATPDMMGVVGRIGRILGPQGLMPNPKAGTVTMDVTSAIKEIKAGKVEYRTDKSNIIHVPVGKVSFGEEKIAENINALMQAILKAKPASSKGKYIRSLTIASTMGPGIKVNPLQFAKE
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: TLRN1_MOUSE
Sequence: MASGSAGKPTGEAASPAPGSAVGGASSQPRKRLVSICDHCKGKMQLVADLLLLSSEARPVLFEGPASPGAGAESFEQCRDTIIARTKGLSILTHDVQSQLNMGRFGEAGDSLVELGDLVVSLTECSAHAAYLAAVATPGAQPAQPGLVDRYRVTRCRHEVEQGCAVLRATPLADMTPQLLLEVSQGLSRNLKFLTDACALASDKSRDRFSREQFKLGVKCMSTSASALLACVREVKAAPSELARSRCALFSGPLVQAVSALVGFATEPQFLGRAAAVSTEGKAVQTAILGGAMSVVSACVLLTQCLRDLAQHPDGSAKMSDHRERLRNSACAVSEGCTLLSQALRERSSPRTLPPVNSNSVN
What is the function of this protein?
Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.
What are the official names of this protein?
Talin rod domain-containing protein 1, Mesoderm development candidate 1.
Protein: TRM6_BOVIN
Sequence: MESSEDQPGPQPQYPGNHCIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNIIGHSYGTTFEVTNGGSLQPKKKKEEPTSETKEAGTDNRNIIDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAMITVVKPSTRILSVMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLNGTFSAEMLSSEPKDIASVEESNGTLEEKQTSEQENEDSIAEAPESNHPEEQERMEIVSQDPDYKEPKESGSKKDYIQEKQRRQEEQKKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVAMDNLKADPSLKSSTSTLESHKTEEPAAKKRKCPESDS
What is the function of this protein?
Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.  Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries.
What are the official names of this protein?
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6, tRNA(m1A58)-methyltransferase subunit TRM6, tRNA(m1A58)MTase subunit TRM6.
What is the protein family that this protein belongs to?
Belongs to the TRM6/GCD10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCH1_HALH5
Sequence: MSKVDHEKIQQAVVMILEAIGEDPAREGLEDTPKRVAKMYEEVFAGLNQDPKEHFATIFGEDHEELVLVKDIPFFSMCEHHLVPFFGKAHVGYIPKGGKVTGLSKLARAVEAVARRPQLQERITSTVADALVETLEPHGVIVVVEAEHMCMTMRGVKKPGAATVTSAVRGTFANDAAARAEVLSLIKG
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: ATP6_WOLTR
Sequence: MALNPLEQFKIHTIVELPKLFGHDINFTNSSLFMMISVVSVILFLLLGVRKGAVIPGYLQAAVEYVYDFITSIIESNTGSKGLKHIPLVFTVFTFTLSCNLVGMLPYSFTVTSHVIVTFALSMIVFTYTTIVGFKEKGINFLRILLPEGIPSWLAPMMVFIKLFAYLARPISLSIRLAANMIAGHTIIKVVAGFIMNMHLILTPIPFLFIIALIGFEVFVAILQAYIFTILTCIYLSDAVK
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FGFR4_PLEWA
Sequence: MGVQKDSRDIRWNRTTRPLALLLCGLLAFSALSCARTLPEGRKANLAELVSEEEEHFLLDPGNALRLFCDTNQTTIVNWYTESTRLQHGGRIRLTDTVLEIADVTYEDSGLYLCVVPGTGHILRNFTISVVDSLASGDDDDEDHGREDSAGDMGEDPPYSTSYRAPFWSQPQRMDKKLYAVPAGNTVKFRCPSAGNPTPGIRWLKNGREFGGEHRIGGIRLRHQHWSLVMESVVPSDRGNYTCLVENKFGSISYSYLLDVLERSPHRPILQAGLPANTTAMLGSDVQFFCKVYSDAQPHIQWLKHIEVNGSRYGPDGVPFVQVLKTADINSSEVEVLYLHNVSFEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDFAKEAEGPETRYTDIIIYTSGSLALLMAAVIVVLCRMQLPPTKTHLEPATVHKLSRFPLMRQFSLESSSSGKSSTSLVRVTRLSSSCTPMLPGVLEFDLPLDSKWEFPRERLVLGKPLGEGCFGQVVRAEAYGINKDQPDKAITVAIKIVKDKGTDKELSDLISEMELMKLMGKHKNIINLLGVCTQDGPLYMIVEYASKGNLREFLRARRPPSPDYTFDMTKVPEEQLSFQDLVSCSYQVARGMAYLESKRCIHRDLAARNVLVTGENVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLTWEIFTLGGSPYPGIPVEELFKLLREGHRMDKPSNCTHELYMLMRECWHAAPSQRPTFKQLVETLDRILATVAEEYLDLSMPFEQYSPACEDTTSTCSSDDSVFTHEPDVPSLFTHHTTTSMVGT
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis.  Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.  Phosphorylates PLCG1 and FRS2.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).
What are the official names of this protein?
Fibroblast growth factor receptor 4, FGFR-4, PFR4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.
Protein: CADH2_CALJA
Sequence: MCRIAGAPRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLPEESVKESTEVEEIVFPRQLGKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAIITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAILDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVNIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD
What is the function of this protein?
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell.  Cadherins may thus contribute to the sorting of heterogeneous cell types.  Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence.  Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity).  Required for proper neurite branching.  Required for pre- and postsynaptic organization (By similarity).  CDH2 may be involved in neuronal recognition mechanism.  In hippocampal neurons, may regulate dendritic spine density.
What are the official names of this protein?
Cadherin-2, Neural cadherin, N-cadherin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma. Cell junction. Cell surface. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes (By similarity). Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes (By similarity).
Protein: TATB_NEIG1
Sequence: MFDFGLGELIFVGIIALIVLGPERLPEAARTAGRLIGRLQRFVGSVKQELDTQIELEELRKVKQAFEAAAAQVRDSLKETDTDMQNSLHDISDGLKPWEKLPEQRTPADFGVDENGNPLPDTANTVSDGISDVMPSERSDTSAETLGDDRQTGSTAEPAETDKDRAWREYLTASAAAPVVQAVEVSYIDTAVETPVPHTTSLRKQAINRKRDFRPKHRAKPKLRVRKS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PG165_VACCC
Sequence: MEIFPVFGISKISNFIANNDCRYYIDTEHQKIISDEINRQMDETVLLTNILSVEVVNDNEMYHLIPHRLSTIILCISSVGGCVISIDNDVNGKNILTFPIDHAVIISPLSKCVVVSKGPTTILVVKADIPSKRLVTSFTNDILYVNNLSLINYLPLSVFIIRRVTDYLDRHICDQIFANNKWYSIITIDNKQFPIPSNCIGMSSAKYINSSIEQDTLIHVCNLEHPFDLVYKKMQSYNSVPIKEQILYGRIDNINMSISISVY
What are the official names of this protein?
Protein OPG165.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG165 family.
Protein: RS3_CLOBL
Sequence: MGQKVHPHGLRVGVIKEWDAKWYADKKNFADNLVEDHKIRNFVKKNSYAAGVSRIEIERAAKRIKLNIYTAKPGMIIGKGGQGIESLKNKLQKIVSNKNILINIVEVKRPEGDAQLIAENIAQQLEKRIAFRRAMKQSIQRAMKSGVKGIKTACSGRLGGAEIARTEHYNEGTIPLQTLRADIDYGFAEADTTYGKIGVKVWVYKGEVLPARKNINEKEEANA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: YI36_SCHPO
Sequence: MFLLSLLHFFHPSLIPSLSLSHTHSSSLPPYRLHCTALSYRDLLTKKSANFRSPIYRSHVNEKGTLTHSFRPTKDMQSGNCWFTILRKARNLLNHGILLSSNNRSFCFIIQISKINPFERFLEM
What are the official names of this protein?
Uncharacterized protein C1399.06.
Protein: OPGB_ECO27
Sequence: MSELLSFALFLASVLIYAWKAGRNTWWFAATLTVLGLFVVLNITLFASDYFTGDGINDAVLYTLTNSLTGAGVSKYILPGIGIVLGLTAVFGALGWILRRRRRHPHHFGYSLLALLLALGSVDASPAFRQITELVKSQSRDGDPDFAAYYKEPSRTIPDPKLNLVYIYGESLERTYFDNEAFPDLTPELGALKNEGLDFSHTQQLPGTNYTIAGMVASQCGIPLFAPFEGNASASVSSFFPQNICLGDILKNSGYQNYFVQGANLRFAGKDVFLKSHGFDHLYGSEELKSVVADPHYRNDWGFYDDTVLDEAWKKFEELSRSGQRFSLFTLTVDTHHPDGFISRTCNRKKYDFDGKPNQSFSAVSCSQENIATFINKIKASPWFKDTVIVVSSDHLAMNNTAWKYLNKQDRNNLFFVIRGDKPQQETLAVKRNTMDNGATVLDILGGDNYLGLGRSSLSGQSMSEIFLNIKEKTLAWKPDIIRLWKFPKEMKEFTIDQQKNMIAFSGSHFRLPLLLRVSDKRVEPLPESEYSAPLRFQLADFAPRDNFVWVDRCYKMAQLWAPELALSTDWCVSQGQLGGQQIVQHVDKAIWKGKTAFKDTVIDMARYKGNVDTLKIVDNDIRYKADSFIFNVAGAPEEVKQFSGISRPESWGRWSNAQLGDEVKIEYKHPLPKKFDLVITAKAYGNNASRPIPVRVGNEEQTLVLGNEVTTTTLHFDNPTDADTLVIVPPEPVSTNEGNILGHSPRKLGIGMVEIKVVEREG
What is the function of this protein?
Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.
What are the official names of this protein?
Phosphoglycerol transferase I, Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the OpgB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NRDR_COXB1
Sequence: MYCPFCNAEDTKVIDSRLVEEGTQVRRRRECLKCQERFTTFETAELNLPRIIKRDGRRSAFDEEKLRAGLLKALEKRPISTEQIETAVQRIIHKLRARGECEVSSQWLGELVMDELRALDEVAYVRFASVYRSFQDINAFRDEIRRLQKQQKKSHDK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: CCNA_SPISO
Sequence: MSQPFALHHDGENQMQRRGKMNTRSNGLSGQKRAALGVITNQVNQQVRIQPSRAAKPKSSEFNIQDENAFTKKNAKTFGQQPSQFSVFVDPTPAAPVQKAPTSHVTDIPAALTTLQRVPLTEVPGSPDIISLEDSMESPMILDLPEEEKPLDREAVILTVPEYEEDIYNYLRQAEMKNRAKPGYMKRQTDITTSMRCILVDWLVEVSEEDKLHRETLFLGVNYIDRFLSKISVLRGKLQLVGAASMFLAAKYEEIYPPDVKEFAYITDDTYTSQQVLRMEHLILKVLTFDVAVPTTNWFCEDFLKSCDADDKLKSLTMFLTELTLIDMDAYLKYLPSITAAAALCLARYSLGIEPWPQNLVKKTGYEIGHFVDCLKDLHKTSLGAESHQQQAVQEKYKQDKYHQVSDFSKNPVPHNLALLAL
What is the function of this protein?
Essential for the control of the cell cycle at the G2/M (mitosis) transition.  Interacts with the CDC2 and CDK2 protein kinases to form MPF.  G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
What are the official names of this protein?
G2/mitotic-specific cyclin-A.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
Protein: DISA_ALKCK
Sequence: MEERNRTAFIQNLLKLVAPGTPLRAGIDNVLRAKTGGLIVLGYNSEMMNIVDGGFFINSDFSPAYLYELAKMDGAIILSEDGKRILYANTQLVPNNNISSSETGIRHRSAERVAKQTGNLTISISQRRNVITLYQGEYRYALKDIGVILTKANQAIQTLEKYKAVLDQGITNLGALEFEQLVTYSDVIQVIHRVQMVLRIKQEIQNFILELGDEGRLITMQLKELVSNTEQEALYLLKDYAKERTQDVKKTLKELTTLLNEDLLDEQAIIKALGYSRTSNFLEQPASPRGYRILHRIPRLPSQIIENVIDEYGHLSSVMVATEDQLDEVDGIGEARAKMIKDGLNRIQEQLFVDRHI
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: LUXQ_VIBHA
Sequence: MTTTRSNIKKRRSLATLITKIIILVLAPIILGIFIQSYYFSKQIIWQEVDRTKQQTSALIHNIFDSHFAAIQIHHDSNSKSEVIRDFYTDRDTDVLNFFFLSIDQSDPSHTPEFRFLTDHKGIIWDDGNAHFYGVNDLILDSLANRVSFSNNWYYINVMTSIGSRHMLVRRVPILDPSTGEVLGFSFNAVVLDNNFALMEKLKSESNVDNVVLVANSVPLANSLIGDEPYNVADVLQRKSSDKRLDKLLVIETPIVVNAVTTELCLLTVQDNQSVVTLQIQHILAMLASIIGMIMIALMSREWIESKVSAQLESLMSYTRSAREEKGFERFGGSDIEEFDHIGSTLESTFEELEAQKKSFRDLFNFALSPIMVWSEESVLIQMNPAARKELVIEDDHEIMHPVFQGFKEKLTPHLKMAAQGATLTGVNVPIGNKIYRWNLSPIRVDGDISGIIVQGQDITTLIEAEKQSNIARREAEKSAQARADFLAKMSHEIRTPINGILGVAQLLKDSVDTQEQKNQIDVLCHSGEHLLAVLNDILDFSKIEQGKFNIQKHPFSFTDTMRTLENIYRPICTNKGVELVIENELDPNVEIFTDQVRLNQILFNLVSNAVKFTPIGSIRLHAELEQFYGAENSVLVVELTDTGIGIESDKLDQMFEPFVQEESTTTREYGGSGLGLTIVKNLVDMLEGDVQVRSSKGGGTTFVITLPVKDRERVLRPLEVSQRIKPEALFDESLKVLLVEDNHTNAFILQAFCKKYKMQVDWAKDGLDAMELLSDTTYDLILMDNQLPHLGGIETTHEIRQNLRLGTPIYACTADTAKETSDAFMAAGANYVMLKPIKENALHEAFVDFKQRFLVERT
What is the function of this protein?
At low cell density, in absence of AI-2 (autoinducer 2), LuxQ has a kinase activity and autophosphorylates on a histidine residue.  The phosphoryl group is then transferred to an aspartate residue in the response regulator domain.  The phosphoryl group is transferred to LuxU, and ultimately to LuxO.  At high cell density, in the presence of AI-2, the kinase activity is inactivated, and the response regulator domain has a phosphatase activity.
What are the official names of this protein?
Autoinducer 2 sensor kinase/phosphatase LuxQ.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SAC1_YEAST
Sequence: MTGPIVYVQNADGIFFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLMGFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADERFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKIHVFSFLQTRGSVPIYWAEINNLKYKPNLVLGENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFHHECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWEDNAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFPDRRPVYIQLIPMIICAALTVLGATIFFPKDRFTSSKNLLYFAGASIVLALSTKFMFKNGIQFVNWPKLVDVGFLVVHQTHDKEQQFKGLKYAQSPKFSKPDPLKRD
What is the function of this protein?
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:10625610, PubMed:11792713).  Has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10625610).  May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton (PubMed:11514624).
What are the official names of this protein?
Phosphatidylinositol-3-phosphatase SAC1, Phosphatidylinositol-4-phosphate phosphatase, Recessive suppressor of secretory defect.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: TARI_STRPJ
Sequence: MIYAGILAGGTGTRMGISNLPKQFLELGNRPILIHTIEKFVLEPSIEKIVVGVHGDWVSHAEDLVDKYLPLYKERIIITKGGADRNTSIKKIIEAIDAYRPLTPEDIVVTHDSVRPFITLRMIQDNIQLAQNHDAVDTVVEAVDTIVESTNGQFITDIPNRAHLYQGQTPQTFRCKDFMDLYGSLSDEEKEILTDACKIFVIKGKDVALAKGEYSNLKITTVTDLKIAKSMIEKD
What is the function of this protein?
Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.
What are the official names of this protein?
Ribitol-5-phosphate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.
Protein: GATA_SORBI
Sequence: MPPPLQAHRLLISHRRLPSPARRRFTAASSLQSAPATTLAPGPATSSILSIRESLLSGERTAADITSEYLSRLRRTEPSLRSFIHVADAAAEREAEELDRRIASGEKDAVGPLAGVLVGVKDNLCTANMPSTGGSRILDGYRPAYDATAVRRLQEAGAIVVGKTNLDEFGMGSTTEGSAFQVTTNPWDDSRVPGGSSGGSASAVSARQCVVSLGSDTGGSVRQPASFCGVVGLKPTYGRVSRFGLMAYASSLDVVGCFGSSVFDTATILSVVAGHDKMDSTSSSQVVPDYASELVSLDLLESKPLAGLRIGIIQETLGEGVANGVISSIKGAASHLEQLGSVVEEVSLPSFSLGLPAYYILASSEASSNLSRYDGIRYGRQFSADDLNELYGESRANGLGHEVKMRILMGTYALSAGYYDAYYKRAQQVRTLVKESFKDALERYDILISPAAPSAAYKIGEKINDPLAMYAGDILTVNVNLAGLPALVVPCGFVEGGPAGLPVGLQLIGSPFCEGNLLRVGHIFEQTLQNLSFVPPLLAES
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, chloroplastic/mitochondrial, Glu-AdT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Plastid, chloroplast stroma.
Protein: CDS_DROME
Sequence: MAEVRRRKGEDEPLEDTAISGSDAANKRNSAADSSDHVDSEEEKIPEEKFVDELAKNLPQGTDKTPEILDSALKDLPDRWKNWVIRGIFTWIMICGFALIIYGGPLALMITTLLVQVKCFQEIISIGYQVYRIHGLPWFRSLSWYFLLTSNYFFYGENLVDYFGVVINRVEYLKFLVTYHRFLSFALYIIGFVWFVLSLVKKYYIKQFSLFAWTHVSLLIVVTQSYLIIQNIFEGLIWFIVPVSMIVCNDVMAYVFGFFFGRTPLIKLSPKKTWEGFIGGGFATVLFGILFSYVLCNYQYFICPIQYSEEQGRMTMSCVPSYLFTPQEYSLKLFGIGKTLNLYPFIWHSISLSLFSSIIGPFGGFFASGFKRAFKIKDFGDMIPGHGGIMDRFDCQFLMATFVNVYISSFIRTPSPAKLLTQIYNLKPDQQYQIYQSLKDNLGDMLT
What is the function of this protein?
Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG) (PubMed:7816135, PubMed:24603715).  Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction (PubMed:7816135).  In the salivary glands and possibly other adipose tissues, function is essential for regulating cell growth and neutral lipid storage by coordinating PtdIns metabolism and insulin pathway activity (PubMed:24603715).  Acts by positively regulating activity of the insulin pathway through synthesis of PtdIns, and in turn the insulin pathway up-regulates the synthesis of CdsA (PubMed:24603715).  This CdsA-insulin positive feedback loop may be one of the mechanisms for coordinating cell growth and fat storage; switching to fat storage when cells reach homeostasis or converting from growth to fat storage under nutrient-poor conditions (PubMed:24603715).  Required for spermatid individualization by regulating lipid compositions and lipid-mediated signaling during spermatogenesis (PubMed:26791243).
What are the official names of this protein?
Phosphatidate cytidylyltransferase, photoreceptor-specific, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PTSS2_CRIGR
Sequence: MRRAERRVAGGSGSGSPLLEGRRSTESEVYDDGTNTFFWRAHTLTVLFILTCSLGYVTLLEETPQDTAYNTKRGIVASILVFLCFGVTQAKDGPFSRPHPAYWRFWLCVSVVYELFLIFILFQTVQDGRQFLKYVDPRLGVPLPERDYGGNCLIYDADNKTDPFHNIWDKLDGFVPAHFIGWYLKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSECWWDHWIMDVLICNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAFQFTPYSWVRFEWKPASSLHRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVNVGGVAMREIYDFMDELKPHRKLGQQAWLVAAITVTELLIVVKYDPHTLTLSLPFYISQCWTLGSILVLTWTVWRFFLRDITMRYKETRRQKQQSHQGRAINNGDGHPGPDDDLLGTGTAEEEGSTNDSVPAEKEGASAAS
What is the function of this protein?
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:12912985, PubMed:9235902).  Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:12912985, PubMed:9235902).  Shows a substrate specificity for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity).  Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity).  Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity).
What are the official names of this protein?
Phosphatidylserine synthase 2, PSS-2, PtdSer synthase 2, Serine-exchange enzyme II.
What is the protein family that this protein belongs to?
Belongs to the phosphatidyl serine synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane. Note=Highly enriched in the mitochondria-associated membrane (MAM).