PharMolix/UniProtQA huggingface dataset:
Protein: NR4A1_CANLF
Sequence: MPCIQAQYGTPAPSPGPRDHLASDPLTPELSKPTMDLASPEAAPTAPTALPSFSTFMDGYTGEFDTFLYQLPGTAQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPLDETLSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGPFSPSQTYEGLRAWTEQLPKASGHPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATCQLGERESYSISTAFPGLAPTSPHLDGPGMLDAPVPSAKARSGAPSGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPGDQDLLLESAFLELFILRLAYRSKPAEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHGLVVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVSAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIVDKIFMDTLPF
What is the function of this protein?
Orphan nuclear receptor.  May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration.  Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'.  May inhibit NF-kappa-B transactivation of IL2.  Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity).
What are the official names of this protein?
Nuclear receptor subfamily 4 group A member 1, Orphan nuclear receptor HMR, Orphan nuclear receptor NGFI-B.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid.
Protein: THYX_MYCSS
Sequence: MAETAPLRVQLIARTEFTVPPDVPWETDAEGGAALVEFAGRACYQSWSKPNPRTATNASYLRHIIDVGHLSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSQVVVPPGIEGDAELEGLFTAAADASRAAYAELLAKLEAKLMGDEPREGRATLRRKQARQAARSVLPNATETRIVVTGNYRAWRHFIAMRASEHADLEIRRLAIACLRELVAVAPAVFADFEIYPLADGTEVATTPLVTEA
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: CYB_MARMR
Sequence: MTNTRKTHPLMKIINRSLIDLPAPSNISTWWNFGSLLGLCLAIQIFTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYTYFETWNIGVILLLAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFVLPFIIAALVMVHLLFLHETGSNNPSGLISNSDKIPFHPYFTIKDVLGILLLILILMILVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVSSILILMLFPLLHLSKQRSMMFRPLSQCTFWILVTDLITLTWIGGQPVEYPYTIIGQLASILYFAIILLILPAISLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CMOA_YERPE
Sequence: MPNRDTQSQNDTPRHSPEAAEPQRDSLFAAPIAKLGDWTFDEKVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPNSQIYDLGCSLGAATLSMRRNIKAEGCKIIAVDNSPAMVERCRRHIDAFRAETPVDVVEADILDIKLENASMVVLNFTLQFLEPANRQRLLNQVYQGLRPGGALVLSEKFSFADHNVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKNRLHQAGFEHAEVWFQCFNFGSLIALKAGEAQ
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: PHOR_ECOLI
Sequence: MLERLSWKRLVLELLLCCLPAFILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGLHQMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGIFWCNGLAQQILGLRWPEDNGQNILNLLRYPEFTQYLKTRDFSRPLNLVLNTGRHLEIRVMPYTHKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMNEQPLEGAVREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTHLLNEKVDVPMMLRVVEREAQTLSQKKQTFTFEIDNGLKVSGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNHHESRLNIESTVGKGTRFSFVIPERLIAKNSD
What is the function of this protein?
Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression.  PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.
What are the official names of this protein?
Phosphate regulon sensor protein PhoR.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTCH2_MOUSE
Sequence: MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQVCQLPGLFCYAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGKVLQYYQESEKPEELGSVTVQKEYSSSFDRVIKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIVTIYREEGIVGFFAGLIPRLLGDIISLWLCNSLAYLINTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGSPPYSPIYTSWIDCWCMLQKAGNMSRGNSLFFRKVPCGKTYCYDLRMLI
What is the function of this protein?
Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane.  Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins.  Does not mediate insertion of beta-barrel transmembrane proteins (By similarity).  Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (PubMed:20436477, PubMed:26219591, PubMed:26876167, PubMed:30510213).  Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (PubMed:20436477, PubMed:26219591, PubMed:26876167).  Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (PubMed:30510213).  Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (PubMed:26876167, PubMed:28127879).
What are the official names of this protein?
Mitochondrial carrier homolog 2, Met-induced mitochondrial protein.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: NU3C_ZYGCR
Sequence: MYTLAGYESFWAFLLIASLVPVLAVGTSSLVAPSSKAAEKRTSYESGIEPMGESWIQFQIRYYMFALVFVVFDVETVFLYPWAMSFQQLGVLAFIEALVFVLVLIIGLVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL27_SALNS
Sequence: MAHKKAGGSTRNGRDSEAKRLGVKRFGGEAVLAGSIIVRQRGTKFHAGTNVGCGRDHTLFAKADGKVKFEVKGPKNRKYISIVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SYC_CALS8
Sequence: MKLYNTLTMTKEEFEPLEEGKVKMYVCGPTVYDFIHIGNARPLIVFDTLRRYFEYKGYEVIYIQNFTDVEDKMINRANKEGITVFELAERFIQEYYKDADRLNVRRATKSPRATEEIEDMIALIQRLIDKGYAYVVDGDVYFRTRKFAEYGKLSHKNIEDLMAGARVDPSEKKEDPLDFALWKAKKEGEPAWNSPWGEGRPGWHIECSVMAMKYLGQTIDIHAGGQDLIFPHHENEIAQSEAATGKPFARFWLHNGYVNINNEKMSKSLGNFFTVREIIEKYHPEALRLFMLQAHYRKPLNFSIDLIEQAEVALKRIYTCYENLEFLIQNAASSSENDDKLKAAIEELKAKFIDAMEDDLNTAEATGYLFEMVREINTHANSCSKETLTFAKDILKELCSILGILEQYSAKEEAIPQEILELVEKRNQARKAKNFLEADRIRDELKSLGYIVLDTPQGTKVERIK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATE_HYPBU
Sequence: MTSSVRIVGDPSRFAEQLVSSIAEHVESRVREALEAARKIVERAYEESASKLESELRRALREAEEQVQAYTAKREVELRKRLAEIRAKAVEEIMSVALQRLREYVGLEAYKEFIKRLLDSALETASRRSRRVIVHPARPDQAIVAELAPRVAAEKGIEVEVGEAVEGAGGFTVRAVEAGLTLDYRLEVILAPALEEARARVLEVLNQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: NDHI_APHJA
Sequence: MFPMVTEFMNYGQQTVRATRYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RUVA_DESVM
Sequence: MIAYVEGRVAEISGNACVVVTEGGVGYEVHLPAHTLSRLPERGGQVAFHVRTEVREDALELFGFSTWDERQTFMVLTTISKVGARTALAILSQFRPDDLRRLVVEDDVLALTRVSGIGKKTAQHIFLELKYKLKVEDLPAGLVLAGGAAPGGVFRDALAGLGNLGYLEDEAAPVLKEVLKAEPDLDVAGALRAALKALARGR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: LEPA_KINRD
Sequence: MSPMATDAPAPAATAPELLRNFCIIAHIDHGKSTLADRMLQLTGVVDARAMRAQYLDRMDIERERGITIKSQAVRMPWGYDGTDYALNMIDTPGHVDFTYEVSRSLAACEGAVLLVDAAQGIEAQTLANLYLAMENDLTIIPVLNKIDLPAAQPEKFAEELAKLIGCEPDDCLRVSGKTGVGVEPLLDQIVRQIPAPVGDADAPARAMIFDSVYDTYRGVVTYVRVIDGNLSPREKIVMMSTRATHELLEIGVSSPEPVPSKGLGVGEVGYLITGVKDVRQSKVGDTVTNAAKPSTKALGGYRDPKPMVFSGLYPIDGSDYPLLRDALDKLKLNDAALSYEPETSVALGFGFRIGFLGLLHLEIVRERLEREFNLDLISTAPSVPYEVTLEDKRVVEVTNPSEFPEGKIAEVREPVVRATVLAPSEFIGAVMELCQQRRGELQGMDYLSEDRVEMRYRLPLAEIVFDFFDQLKSRTRGYASLDYDVDGDQAADLVKVDVLLQGEQVDAFSQIVHREKAYGYGVMMAGKLKDLIPRQQFEVPIQAAIGARVIARENVRAIRKDVLAKCYGGDITRKRKLLEKQKEGKKRMKMVGRVEVPQEAFIAALSSDAAGDKAKDKNAKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS19_METTH
Sequence: MARKEFRYRGYTLEELQEMPLDDVIKLFPSRQRRSLKRGFLPRQKKVLEKIRKIKKEGKTEGRPPVIRTHCRDMIVLPEMVGMTFGIHNGKEFVEVKIQPEMIGCYFGEFAPTRKKVEHGDPGMGATRFSMFVPLK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: NDVA_BRUME
Sequence: MSLLKIYWRAMQYLAVERTATITMCVASVLVALVTLAEPVLFGRVIQSISDKGDIFSPLLMWAALGGFNIMAAVFVARGADRLAHRRRLGVMIDSYERLITMPLAWHQKRGTSNALHTLIRATDSLFTLWLEFMRQHLTTVVALATLIPVAMTMDMRMSLVLIVLGVIYVMIGQLVMRKTKDGQAAVEKHHHKLFEHVSDTISNVSVVQSYNRIASETQALRDYAKNLENAQFPVLNWWALASGLNRMASTFSMVVVLVLGAYFVTKGQMRVGDVIAFIGFAQLMIGRLDQISAFINQTVTARAKLEEFFQMEDATADRQEPENVADLNDVKGDIVFDNVTYEFPNSGQGVYDVSFEVKPGQTVAIVGPTGAGKTTLINLLQRVFDPAAGRIMIDGTDTRTVSRRSLRHAIATVFQDAGLFNRSVEDNIRVGRANATHEEVHAAAKAAAAHDFILAKSEGYDTFVGERGSQLSGGERQRLAIARAILKDSPILVLDEATSALDVETEEKLKQAVDELSHNRTTFIIAHRLSTVRSADLVLFMDKGHLVESGSFNELAERGGRFSDLLRAGGLKLEDKQPKQPVVEGSNVMPFPVKGAVA
What is the function of this protein?
Involved in beta-(1-->2)glucan export.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity).
What are the official names of this protein?
Beta-(1-->2)glucan export ATP-binding/permease protein NdvA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Beta-(1-->2)glucan exporter (TC 3.A.1.108.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LUXS_ALIF1
Sequence: MNIKNINANEKIIDKIKTCNNNKDINQCLSEIAKIIHCEYYLFAIIYPHSIIKPDVSIIDNYPEKWRKYYDDAGLLEYDPVVDYSKSHHSPINWNVFEKKTIKKESPNVIKEAQESGLITGFSFPIHTASNGFGMLSFAHSDKDIYTDSLFLHASTNVPLMLPSLVDNYQKINTTRKKSDSILTKREKECLAWASEGKSTWDISKILGCSERTVTFHLTNTQMKLNTTNRCQSISKAILTGAINCPYLKN
What is the function of this protein?
Transcriptional activator of the bioluminescence operon.  Binds to the OHHL autoinducer.
What are the official names of this protein?
Transcriptional activator protein LuxR.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-regulated transcriptional regulatory protein family.
Protein: TESK1_MOUSE
Sequence: MAGERPPLRGPGPGEAPGEGPGGAGGGPGRGRPSSYRALRSAVSSLARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGNDCPLPFLLLAIHCCSMEPSTRAPFTEITQHLEQILEQQPEATPLAKPPLTKAPLTYNQGSVPRGGPSATLPRPDPRLSRSRSDLFLPPSPESPPSWGDNLTRVNPFSLREDLRGGKIKLLDTPCKPATPLPLVPPSPLTSTQLPLVTTPDILVQPETPVRRCRSLPSSPELPRRMETALPGPGPSPMGPTEERMDCEGSSPEPEPPGLAPQLPLAVATDNFISTCSSASQPWSPRSGPPLNNNPPAVVVNSPQGWAREPWNRAQHSLPRAAALERTEPSPPPSAPREPEEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGARS
What is the function of this protein?
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity).  Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity).  Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (PubMed:30115939).  Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (By similarity).  Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity).  Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).
What are the official names of this protein?
Dual specificity testis-specific protein kinase 1, Testicular protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, lamellipodium. Note=Colocalizes with SPRY4 in vesicular spots in the cytoplasm (By similarity). Localized to F-actin- rich lamellipodia at the cell periphery following fibronectin-mediated cell adhesion of Schwann cells (By similarity).
Protein: RNY_STRGC
Sequence: MEMIFALVFAVIIGLVIGYVSISARMKSSKEAAELTLLNAEQEATNLRGQAEREADIILKDAKRETNSLKKEALLEAKEEARKYREEVEAEFKSERQELKQTESRLTERAASLDRKDDNLTNKEKLLEQKEQSLSDKTKYIDEREEQLAELEKQKEAELERVASLSQNEARDLILAQTEEKLTKEIAMRIREAEQEVKERSDKMAKDILVQAMQRIAGDYVAEQTNSTVHLPDDTMKGRIIGREGRNIRTFESLTGIDVIIDDTPDVVTLSGFDPVRREIARMTMEALLKDGRIHPARIEELVEKNRLEIDNRIREYGEAAAYEIGAPNLHPDLMKIMGRLQFRTSYGQNVLRHSIEVAKLAGVIAGELGENATLARRAGFLHDIGKAIDREVEGSHVEIGTELARKYKENPIVVNTIASHHGDVEAESVIAVIVAAADALSAARPGARSESLESYIKRLHDLEEIANEFDGVKTSFALQAGREIRIMVHPEKIKDDKVTILAHDVREKIENNLEYPGNIKVTVIRELRAVDYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: LIPA_RHILO
Sequence: MVTVLDAIANAPRLRHPEKAHKPDQEVLRKPDWIRVKAPVSKGYAETREIVKSHKLVTVCEEAGCPNIGECWEKKHATFMIMGEICTRACAFCNVATGIPTALDPDEPARVAHAVKQMGLSHVVITSVDRDDLADGGAQHFADVIRAIRAATPSTTIEILTPDFLRKDGALEIVVAARPDVFNHNLETVPSNYLKVRPGARYFHSIRLLQRVKELDPSIFTKSGIMVGLGEERNEILQLMDDLRSANVDFMTIGQYLQPSKKHHPVIRFVTPEEFKSFETIGRTKGFLLVASSPLTRSSHHAGDDFARLRAAREAQLQKSV
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CASL_CANLF
Sequence: MWARNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPIQETPSGQDQPTSGLMHQTFGQQKLYQVPNPHSAPRDTIYQVPPSYQHQGIYQVPTSHGIQEQDVYQVPPSVQRSIGAANGPHLSKKVVTPVRTGQGYVYEYPSRHQKDIYDIPPSHTTQGVYDIPPSSVKVPVFSLPVGEIKPQGVYDIPPTKGLYAIPPSACRDEAGLREKEYDFPPPMRQAGRLDVRPEGVYDIPPTSTKPTGKDLHIKYNCDAPGAAELATRRHQSVLLNHAPSQLGQSPGAQNDAYDVPRGVQFLEPPAETSEKANPEERDGVYDVPLHNPPDAKGSQDVVDGMNRLSFSSTGSTRSNMSTSSTTSKESSVSASPSQDKRLLLDPDTAIERLHRLQQTLEVGVSSLMALVTTDWRCYGYMDRHINEIRTSVDKVELFVRDYLHFARGAVANASCLPELTLHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAVNKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALFRPGPGSSHVKSGSENIMNSTEYPHAASQMPLLHPGDHKAQGLNKPLPPSLGKDQPPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIIKQNKLQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSSVGAQDRQLLCFYYDQCETHYISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQDICHKVMNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
What is the function of this protein?
Negatively regulates embryonic fibroblast migration (By similarity).  May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells.  Integrin beta-1 stimulation leads to recruitment of various proteins including CRKl and SHPTP2 to the tyrosine phosphorylated form (By similarity).  Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (By similarity).  Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity).  Negatively regulates cilia outgrowth in polarized cysts (PubMed:27926875).  Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity).  In conjunction with NKX2-5, positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity).  Positively regulates RANKL-induced osteoclastogenesis (By similarity).  Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity).
What are the official names of this protein?
Enhancer of filamentation 1, CRK-associated substrate-related protein, CAS-L, Neural precursor cell expressed developmentally down-regulated protein 9, NEDD-9, p105.
What is the protein family that this protein belongs to?
Belongs to the CAS family.
Protein: SYL_BRUO2
Sequence: MAAERYNPRVAEAHWQKVWEENRTFETDNSDSREKYYVLEMFPYPSGRIHMGHVRNYAMGDVVARYKRAKGFNVLHPMGWDAFGMPAENAAMQNKVHPKEWTYQNIATMKRQLKSMGLSLDWSREFATCDVEYYHRQQMLFIDLYEKGLVTRKTSKVNWDPVDNTVLANEQVVDGRGWRSGALVEQRELTQWFFKITDFSEELLAGLDTLDQWPEKVRLMQRNWIGKSEGLQVRFALAAGTAPAGFSEVEVYTTRPDTLFGAAFVAISADHPLAKKLSEGNAALSSFIEECHQQGTSLAALETAEKKGFDTGIKVKHPFDDNWELPVYVANFVLMEYGTGAVFGCPAHDQRDLDFANKYKLKVTPVVLPKGEDAASFSIGETAYTDDGVMINSRFLDGMTPEAAFNEVASRLEKTDLVGRPQAVRKVQFRLRDWGISRQRYWGCPIPMIHCESCGVNPVPRADLPVKLPDDVEFDRPGNPLDRHATWRHVKCPKCGGDARRETDTMDTFVDSSWYYTRFTAPWENEPTDRKAADHWLPVDQYIGGIEHAILHLLYSRFFTRAMKVAGHVGVDEPFKGLFTQGMVVHETYKANGQWVSPADIRIEEIDGKRVATMLDSGAPVEIGSIEKMSKSKKNVVDPDDIIASYGADTARWFVLSDSPPERDVIWTEAGAEGAHRFVQRIWRLVAEAAPALKDVAPKAGTQGEALGVSKAAHKAVKAVGDDIEKLAFNRGVARLYELVNTLSGALQQAADGKADAEMKGALREATEMLVLMTAPMMPHLAEQCLAELGGKVAGKETLVARAPWPVFDPALVVENEIVLPVQINGKKRGDLTIARDADQASIQQAVLELDFVKAALNGGSPKKIIVVPQRIVNVVA
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIB3_CANAL
Sequence: MTNIFTPIEEALEAYKNGEFLIVMDDEDRENEGDLIMAAELITQEKMAFLVRYSSGYVCVPLSEERANQLELPPMLANRSDRHGTAYTITCDFAEGTTTGISAHDRALTTRSLANPNSKPQDFIKPGHILPLRAVPGLLKKRRGHTEAAVQLSTLAGLQPAGVICELVRDEDGLMMRLDDCIQFGKKHGIKIININQLVEYISK
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.