PharMolix/UniProtQA huggingface dataset:
Protein: PRR14_MOUSE
Sequence: MDLPGNSSPFTQPSLCRQPLSRASWEARSPKRPRLQPLGTPSSLEKASRRVLAVVLEDVMTTNRVPLTHKEDTPSPLTHNHHQDPVCTQSPALPSQQVKWSMQARPPDPLHLCREPLTRARQSSPALRMRSRAASGPEESPSKKTDQVPQPTLVVVLEDIASGRQPAEGFDEDQPNLIVPAQSTFRSLKGPGKHCHRRGLDLEARPTLTLSLHPRAEPVTKAGQPMPTPSDLEPPFQLSTLPADPPESPVPDPALETPVIPTSSSLLRPRLSPWGLAPLFRSVRSKLESFADIFFTPNKTPQPPPPSPPMKLELKIAISEAEQSRATEKITSVSPRPPIRQWRTQCNSLAPVSKSSLGRSYSCPDLGPPDPGSWPPVPSQPSQSRPRRHTVGCGEMARTPPPPRPCLRKEVFPLGGVGVSPSLTTSCSANAPASFFCEPAEPRLGSTKGKELRASKDKVFSDPETKTMGKVSRFRIRRTPVRLQPNLTPMGLPRPIRLNKKEFTLEEIYTNKNYQSPTTRRTFETIFEEPRERNGTLIFTSSRKLRRAVEFRDSSLPRSRRPSRGVRTAASRTLTPNLAPSQDVGSLLQERLRELDALLLEEETDKEHPCHL
What is the function of this protein?
Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (By similarity).  Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (By similarity).  Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157) (By similarity).  Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (By similarity).
What are the official names of this protein?
Proline-rich protein 14.
What are the subcellular locations of this protein?
Chromosome. Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Note=During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase.
Protein: PETL_THAPS
Sequence: MSILINYFLLVGFCFALASGLFLGLKSIKLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PPAX_BACMK
Sequence: MKINTVLFDLDGTLINTNELIISSFLHTLNHYYSNQYKREDVLPFIGPSLHDTFSKIDASKVEEMITCYRQFNHEHHDELVEEYETVYETVQELKKQGYKIGIVTTKARQTVEMGLKLSKLDQFFDVVVTIDDVEHVKPHPEPLQKALELLDAKPEETLMVGDNHHDIVGGQNAGTKTVAVSWTLKGRAYLEAYKPDYVLDKMSDLLPILSRING
What is the function of this protein?
Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P.  Might play a role in controlling the intracellular pyrophosphate pool.
What are the official names of this protein?
Pyrophosphatase PpaX.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PpaX family.
Protein: XDH_DROSU
Sequence: MSGQQQATSVLVFFVNGKKVTDTNPDPECTLLTYLRDKLRLCGTKLGCAEGGCGACTVMISRMDRGQHKIRHLAVNACLTPVCAMHGCAVTTVEGIGSTRTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRNAEQPSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFLCGMGEKCCRVNGKGCGGGDDPESVTDDTLFERSKFQPLDASQEPIFPPELQLSNAYDSESLVFSSERVTWYRPTTLQELLQLKAAHPAAKLVVGNTEVGVEVKFKHFLYPHLINPTLVAELQEVRESEESIYFGAAVSLMEIDALLRQRIEELPEAQTRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLTAAGARLEVASIVEGKISQRTVHMGTGFFTGYRRNVIEPQEVLLGIHFQKTTPDQHVVAFKQARRRDDDIAIVNAAVNVRFEPKSNVVAEISMAFGGMAPTTVLAPRTSQLMVKQPLDHQLLERVAESLCGELPLAASAPGGMIAYRRALVVSLIFKAYLAISSKLSEAGIIAGDAIPPKERSGAELFHTPTLRSAQLFERVCSDQPVCDPIGRPEVHAAALKQATGEAIYTDDIPRMDGELYLGFVLSTKPRAKITKLDASAALALEGVHAFFSHKDLTVHENEVGPVFHDEHVFAAGEVHCYGQIVGAVAADNKALAQRASRLVRVEYEDLSPVIVTIEQAIEHGSYFPDYPRYVTKGNMAEAFAQAEHTYEGSCRMGGQEHFYLETHAAVAVPRDSDELELFCSTQHPSEVQKLVAHVTSLPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRLRRPVRCMLDRDEDMLITGTRHPFLFKYKVAFSSDGLITACDIECYNNAGWSMDLSFSVLERAMYHFENCYHIPNVRVGGWVCKTNLPSNTAFRGFGGPQGMFAGEHIIRDVARIVGRDVLDVMRLNFYRTGDTTHYNQQLEHFPIERCLDDCLTQSRYHERRAEIAKFNRENRWRKRGVAVIPTKYGIAFGVMHLNQAGALLNVYGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNTSPTAASVGSDINGMAVLDACEKLNKRLAPIKEALPQATWQEWINKAYFDRVSLSATGFYAMPGIGYHPETNPNARTYSYYTNGVGISVVEIDCLTGDHQVLSTDIVMDIGSSINPAIDIGQIEGAFMQGYGLFTLEELMYSPQGMLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGEPPLFIGASAFFAIKEAIAAARQEHGLTGDFPLEAPSTSARIRMACQDKFTNLLEVPEAGSFTPWNIVP
What is the function of this protein?
Key enzyme in purine degradation.  Catalyzes the oxidation of hypoxanthine to xanthine.  Catalyzes the oxidation of xanthine to uric acid (By similarity).
What are the official names of this protein?
Xanthine dehydrogenase, XD, Protein rosy locus.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: RIC8A_DANRE
Sequence: MDLNAIIEKMETGDQDAALTALQTYNKEKSQCFSFTSGEEEDRERLGELVLSFLERDLQPSCQLACLETIRILSRDKKSLSPFATRHAMQILIRHAGLGQGEGVTPEIPDLEVIVEALKCLCNIVFNSEAAQEAAADLQLMVGLAERLKQCREPQWNHDVRFFDLRLTFLITALRVDVRAQLAHELRGVSLLSEALDATFGLCWPDMYEVARAGFDGCSELPPLGRQETERVMEILKILFNVTFDSNRRHVDEEEAATYRHLGAILRHCIMSSAEGEERTEEMHSHTVNLLGNLPLPCLDVLLMPKVQQGSIEYMGVNMDAVKVLVEFMEKRLDRGNKLKETLLPSLNLLTESARIHRETRKFLRNKVLPPLRDVKNRPEVGNALRNKLVRLMTHIDTDVKHCAAEFLFVLCKESVSRFIKYTGYGNAAGLLAARGLMRGGRDPGHYSEDEDSDTEEYREAKPHINPVTGRVEEEQPNPMEGMTDEQKEYEAMKLVNMFDKLSREQVIQPMKIGADGKMTSMEPHELHHLASQQFGESNNSDSDSDTN
What is the function of this protein?
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.  Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).
What are the official names of this protein?
Synembryn-A, Protein Ric-8A.
What is the protein family that this protein belongs to?
Belongs to the synembryn family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane.
Protein: AROK_AERHH
Sequence: MAEKRNIFLIGPMGAGKSTIGRHLAEQLHMEFFDSDHEIERRSGADIGWVFDVEGEEGFRIREEKVIGDLSEQQGIVLATGGGAIKSRETRNKLSARGIVVYLETTIEKQLARTQRDKRRPLLQTEEPPREVLERLAQERNALYEEVADFVIQTDDQSAKVVANQIVKLIGM
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_BURCJ
Sequence: MRILGIDPGLRVTGFGVIDVSGHRLAYVTSGVIRTPTADLATRLGTIFQGVSTIVREHAPDQAAIEKVFVNVNPQSTLLLGQARGAAICGLVAGGLPVAEYTALQLKQAVVGYGRATKTQMQEMVTRLLNLSGQPGSDAADALGMAICHAHGGNTLSTLGGLAPALAQKGLRVRRGRLVG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: COBS_CALS4
Sequence: MEELKALILSIQFMTGIPIPINIDVKEDKIYKIASYFPVVGLLIGGILYIAYLLLKDLFSREIVMTFLVAFSYILTRGMHIDGLADTFDGLFSNKDREKIIEIMKDSRLGTNGVLALVFMVILKILFLSDIRQSLLFSALLVSPVIARLSVVFSIAISKSARGGKGLGGLLLERAGLREFVIALLISTIAGYFVMPLKDLALLYVISLSFTCLISKYISKKIGGMTGDTLGAVNEFVELIAFIYFSIL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MLTF_MARN8
Sequence: MSRFISTFRSSSAQLSIVLAVILATGCSQPTTLQEIREEGVLHVITRVAPSIYYQDREQDTGYDYELARLFANELGVELRVRVADDNSEILSVLSRNYAHVGLAGLTQRPDFDNQYRSVPIGVSAQSVIVYHKEVPAPESLEDLASETIHMLADSNHEHLIADPANEAGPIIQKHPGLDAAGLLARVESGEFGYAAVASNELDLNHVFFPKVYEAFALNEPSDLVWLFPAAQDDTLVNAAEAFMERVNNNGTMAQLAERFYGHLDRLNYVGARTFMHHVENRLPRYQSLFKDYAQESGMDWRLLAAIGYQESHWRPNAVSPTGVRGLMMLTRTTANYIGINNRLDAEESIEGGARYFRMVHGRIPDRIPEPDRTWFALASYNVGFGHLEDARRLAESAGKDPDRWMDVKEFLPLLAQKEWYTKTRFGYARGHEPVVYVQNIRRYYDVLVRITEPDAPSASGLEDQLAWLGDNEAGPEAPAKESQPDLRADLPPELRLIPPTL
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: HIDE1_MOUSE
Sequence: MPWTILLFASGSLAIPAPSISLVPPYPSSHEDPIYISCTAPGDILGANFTLFRGGEVVQLLQAPSDRPDVTFNVTGGGSGGGGEAAGGNFCCQYGVMGEHSQPQLSDFSQQVQVSFPVPTWILALSLSLAGAVLFSGLVAITVLVRKAKAKNLQKQRERESCWAQINFTNTDMSFDNSLFAISTKMTQEDSVATLDSGPRKRPTSASSSPEPPEFSTFRACQ
What are the official names of this protein?
Protein HIDE1, Highly expressed in immature dendritic cell transcript 1 protein.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: AAS_SALPB
Sequence: MLFGFFRNLFRVLYRVRVTGDVRALQGNRVLITPNHVSFIDGMLLALFLPVRPVFAVYTSISQQWYMRWLTPLIDFVPLDPTKPMSIKHLVRLVEQGRPVVIFPEGRISVTGSLMKIYDGAGFVAAKSGATVIPLRIDGAELTPFSRLKGLVKRRLFPRIQLHILPPTQIPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLVAQYRYGAGKNCIEDINFTPDTYRKLLTKTLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLAVPGIENGGRLQLKGPNIMNGYLRVEKPGVLEVPSAENARGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFTTDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE
What is the function of this protein?
Plays a role in lysophospholipid acylation.  Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium.  Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
What are the official names of this protein?
Bifunctional protein Aas.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MLC2_YEAST
Sequence: MDHSESLTFNQLTQDYINKLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDTSTAEVGEEGVSFPIFLSIMGKNLSQFPEREELEESLKAIGRGHDLNVPLNEVIDSLKEAGFENPEEEFAKLFKLFTTNQQATEERTFRGKLFLDSITD
What is the function of this protein?
Regulatory light chain for the class II conventional myosin MYO1.  May play a role in the disassembly of the MYO1 ring at the bud neck at the end of its contraction during cytokinesis.
What are the official names of this protein?
Myosin light chain 2, Calmodulin-like myosin light chain MLC2, MYO1 light chain 2, Myosin-1 light chain.
What are the subcellular locations of this protein?
Bud neck. Note=Forms a ring at the bud neck in a MYO1-dependent manner.
Protein: MED10_MACFA
Sequence: MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQGLSKVFPEDMAKYRSIRGEDHLPS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 10, Mediator complex subunit 10.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GUAA_BRUAB
Sequence: MSTTAYPDTILIIDFGSQVTQLIARRVREANVYCEIVPFQSADEAFKRLQPKGVILSGSPHSTTDIGSPRAPQAIFDAGIPVLGICYGEQTMCAQLGGNVESGHDREFGRAFLDVQEDSPLFAGIWAKGTRHQVWMSHGDRVTSLPDGFTIIGTSPNAPYAVIADEKRKYYGVQFHPEVVHTPDGAKLLQNFVHRIVGVKPGWTMGAYREQAVEAIRKQVGSGKVICALSGGVDSSVAALLAHEAVGDQLTCILVDHGLMRKDEAQQVVEMFREHYNLPLILVDASDRFIGALEGESDPEKKRKTIGRLFIEVFEEEARKLGGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMKMQLVEPLRELFKDEVRLLGKELGLPDSFIGRHPFPGPGLAIRCPGGVTREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADFYHYDMNFLGNAATRIINEVRGINRVVYDVTSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RDRP_SHMV
Sequence: MSTSTLINKAQTNSCGDVGVVDLLKRKVYDDTVKTMQGLDRRAKYRLNQCLGPEQCRTVRGGYPEFQIEFTGASNTSHAMAAGLRGLELEYLYTLVPYGAVSYDIGGNFPAHMMKGRSYVHCCNPALDARDLARNENYRISIENYLSRFEDKSGDYCQWQRKKPKVSKPLPRYQKACFDRYNEDPEHVTCSETFEKCRISPPAERDDIYATSLHSLYDIPYQNLGPALARKRIKVLHAAFHFSEDLLLGASEGLLTQIGGTFQRNGDVLTFSFLDESSLIYTHSFRNVFEYVTRTFFVACNRYAYMKEFRSRRVDTVFCSFIRIDTYCLYRSVFKDCDEHVFAAMDDAWEFKKKRVMLEASRPIFNDVAQFNVYFPNAKDKVCLPIFAVKSVSGAPVTTRHILVEKDFYWTALNHILTYPDGKADFRGVMSFLESIRSRVVINGTTTASQWEVDKSQLKDIALSLLLIAKLEKLKISVIEKRIKIERQGLVSLLKEFLHGLLDEYTQTMAEWVVEKGWVKSVDQVLQVTIPDLVLNFRDHFRCEFRTSANVSEVNVSEHLVATNEYYAKVSDLVDRNPTLAFDFEKFQDYCEKLGVDIDTVTELIDAISTGRAGITLDHTDDKEEQLPRTLAGSSSYLEEEPSDDLVCLSDKAIVNRSTILGELKNNVVIFEGTLPKNSVFVSAPDDPSVTIELSELHARPVSDFLSMQKPVNIVYTGEVQICQMQNYLDYLSASLVACISNLKKYLQDQWLNPGEKFQKIGVWDNLNNKWIVVPQKKKYAWGLAADVDGNQKTVILNYDEHGMPILEKSYVRLVVSTDTYLFTVVSMLGYLRHLDQKKPTATITLVDGVPGCGKTQEILSRFDANSDLILVQGREACEMIRRRANDNVPGSATKENVRTFDSFVMNRKPGKFKTLWVDEGLMVHPGLINFCINISCVSSVYIFGDRKQIPFINRVMNFSIPDNLAKLYYDEIVSRDTTKRCPLDVTHFLNSVYEKRVMSYSNVQRSLECKMISGKAKINDYRSILAEGKLLTFTQEDKEYLLKAGFKDVNTVHEAQGETYRDVNLIRVTATPLTIVSAGSPHVTVALSRHTNRFVYYTVVPDVVMTTVQKTQCVSNFLLDMYAVAYTQKXQLQISPFYTHDIPFVETNKVGQISDLQYFYDSWLPGNSFVQNNHDQWSIISSDINLHSEAVRLDMNKRHIPRTKGEFLRPLLNTAVEPPRIPGLLENLLALIKRNFNAPDLAGQLDYDFLSRKVCDGFFGKLLPPDVEASELLRLPVDHMYSVQNFDDWLNKQEPGVVGQLANWDHIGMPAADQYRHMIKRTPKAKLDLSIQSEYPALQTIVYHSKHVNAVFGPIFSCLTERLLSVVDPLRFKFFTRTTPADLEFFFRDMVVGDMEILELDISKYDKSQNKFHFEVEMRIWEMLGIDKYIEKVWENGHRKTHLRDYTAGIKTVIEYQRKSGDVTTFIGNTIIIAACLCSILPMEKVFKAGFCGDDSIIYLPRNLLYPDIQSVSNNMWNFEAKLFKKLHGYFCGRYXLRNGRYLRLLPDPLKIITKLGCKAIKDWDHLEEFRISMFDMACEYKNCFGFDVLESAVKESFPKAEGCNVAFCAIYKFLSNKYLFRTLFSDV
What is the function of this protein?
Is a methyltransferase active in RNA capping and an RNA helicase.  Methyltransferase displays a cytoplasmic capping enzyme activity.  This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus.  Helicase region probably exhibits NTPase and RNA unwinding activities (Potential).  It also acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  May mediate silencing suppression through either inhibition of HEN1-mediated siRNA or siRNA demethylation (By similarity).
What are the official names of this protein?
Replicase large subunit, 183 kDa protein, RNA-directed RNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: PCK2_SCHPO
Sequence: MDMIDEAITEVVRKIERERSVIHGALSMKRLTQNQTVHQQLHSNIEESKKSIIYLEERLEKLKLRKNGVRKSNSEKPSVGIEKNPSFSTTKSAKSFSSTSSNIDSNLDLLNYDTPLTISKISFLLQQLEFKLSVEEQYRKGIEKMAKLYEREHDRRSIAEAEKKYVESAQKITLLKQALKRYHDLHIEIDEEDVPSTESRGNLNARRPQSGLLKITVGSLRNVTHSAGISKQTEMIVAIRAEDLERARTRPSRTDRFNETFEIDLEKTNEVEIVVYEKKNEKLLLPVGLLWIRLSDLVEKQRRKKVEQEVSDKGWVSADKMINQRLSIFLPSALNNISKPESTDRPNTASGNQSVSAWFSLEPMGQINLTMNFTKHNTRKRPMDAGLGRQGAIRQRKESVHEVYGHKFLQHQFYQIMRCALCGEFLKNAAGMQCIDCHYTCHKKCYPKVVTKCISKSSDSASSEYEKINHRIPHHFESHTNIGANWCCHCGYILPLGRKTARKCTECGITAHAQCVHLVPDFCGMSMEMANRVISEIRTTKIYKAQQHKQKSSHHKHHHHKKSKSSSSKHKENDKASVSITTTTTPSITPADPVPTSPKPLAIEPVKRKPVHAGNLEVTSVSDNKLGATVQVVEQKVDDKADALTKPPSLDAVKEPIPVPSVETSVVAQDLTHKAKRIGLEDFTFLSVLGKGNFGKVMLAELKSEKQLYAIKVLKKEFILENDEVESTKSEKRVFLVANRERHPFLVNLHSCFQTETRIYFVMDFVSGGDLMLHIQQEQFSRRRAQFYAAEVCLALKYFHDNGIIYRDLKLDNILLSPDGHVKVADYGLCKEDMWHDNTTATFCGTPEFMAPEILLEQQYTRSVDWWAFGVLIYQMLLGQSPFRGEDEEEIFDAILSDEPLYPIHMPRDSVSILQQLLTRDPKKRLGSGPNDAEDVMTHPFFSNINWDDIYHKRTQPPYIPSLNSPTDTKYFDEEFTRELPVLTPVNSILTKEMQQHFEGFSYSCEDDKPSTTDNA
What is the function of this protein?
Involved in the control of the cell shape.  Target of the inhibitor staurosporine.
What are the official names of this protein?
Protein kinase C-like 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Protein: UN50A_XENLA
Sequence: MLPTTSVSPRSPDNGILSPREAARHTAGAKRYKYLRRLFHFKQMDFEFALWQMLYLFTSPQKVYRNFHYRKQTKDQWARDDPAFLVLLSIWLCVSTVGFGFVLDMSFFETFKLLLWVVFIDCVGVGLLIATLMWFVSNKYMVKRQGKDYDVEWGYTFDVHLNAFYPLLVILHFIQLFFINHVILSGWFIGYFVGNTIWLIAIGYYIYITFLGYSALPFLKNTVILLYPFAALALLYVLSLALGWNFTEKLCLFYKYRVR
What is the function of this protein?
Involved in the cell surface expression of neuronal nicotinic receptors (By similarity).  Binds RNA (By similarity).
What are the official names of this protein?
Protein unc-50 homolog A.
What is the protein family that this protein belongs to?
Belongs to the unc-50 family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: UBP16_SCHPO
Sequence: MSLATLQGQSLDFAVKHSLDDLLKNPVRFRPAVVSSPSVPEGTYTVLNNPKQSTVSRKSFSAPTSPTRNKRSGSSSQEYKKSSGTRGDGANDFVDEDPAFIPPARILFPEEKLSMEWDNIMPNAPGLVNLGNTCFMNSVLQLMTQTPPLVQYLLSGQHSLSCRMNACVLCRMEQHVARAYPNKGTKRASAFKPSGIQSMLKVISSHFRPYRQEDAHEFMRYLVDAWQKSCLQNHKNLDHPSRETSVVHRIFGGYLRQQILCSVCKKPSNTYQALLDLSVDAKGSSLADSLKHFVHAEKLTKQNKYRCENCKQLVDASKQMTIYRAPNILTIHFKRFTFNGFQSSKISKQISYPESFNLGPYMSDPNCSCWYELIGVLVHAGGSTRSGHYYSFCKSSNGVWLKFDDDFVSNSSIDRVLNQQAYILQYKRKSTSSSKHKLNTENTVTKTSNKKRRKISF
What are the official names of this protein?
Probable ubiquitin carboxyl-terminal hydrolase 16, Deubiquitinating enzyme 16, Ubiquitin thioesterase 16, Ubiquitin-specific-processing protease 16.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: EX7L_CYAP4
Sequence: MSFTQPNLLFPPTVLSVGGLTQYIQTLLEQDEELMQVWVTGEVSSASQHRSGLFFTLQDPDERVALRCIVWASQLEKLSILPVPGEQVILLGRIRVYPQRGEYQLMVWQALPAGEGLMALRYRQLRDRLETEGLFDPARKRPLPPHPQTIAVVTSPQAAAWGDIQRTLSHRYPGLRVLLSPALVQGDQAPDSIVAAIERVEKDGRAEVLILSRGGGATEDMACFNHERVVRAIAECSIPVIAGIGHQRDESLADLVADVHVHTPTAAAQLAVPDLAELYTEHCQRLDHLITAGQTRLALAQNQLQHQNRRLKRLPLERQLVQEGRAIAHLKQQLIQTVSQQLQQRLTHQQLLAQKLQSLDPRAILQRGYAIARRQNGQILRTIAALQEGDDLTLQLSDGQVKVQVRKIMAAGTGHEAESEQMEL
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y623_RICBR
Sequence: MPKTINNYNRFLPVVHFSQTELEESLCNAVIHNDKKAAEIAIFKLNISDNFTSDLRTNKSYIDDTHNIFIGDSLPLVAVKNNNLDMLKMLLSCGFEPNTPAAANCYTPLWYVTYKGYTNSVRKLLEYPINNINETFGKETPLKSALIHKHTEIAKLLIDKINPDKFLFNGVENIALLAHDQFMFIINEISTDKKISLFKLCSKNITEHQDFILFGKGEAEINNMHINNTYMLDYLDNNHDDSTTIIGSID
What are the official names of this protein?
Putative ankyrin repeat protein RBE_0623.
Protein: CYSP2_HAECO
Sequence: MKYLVLALCTYLCSQSGADENAAQGIPLEAQRLTGEPLVAYLRRSQNLFEVNSDPTPDFEQKIMSIKYKHQKLNLMVKEDPDPEVDIPPSYDPRDVWKNCTTFYIRDQANCGSCWAVSTAAAISDRICIASKAEKQVNISATDIMTCCRPQCGDGCEGGWPIEAWKYFIYDGVVSGGEYLTKDVCRPYPIHPCGHHGNDTYYGECRGTAPTPPCKRKCRPGVRKMYRIDKRYGKDAYIVKQSVKAIQSEILKNGPVVASFAVYEDFRHYKSGIYKHTAGELRGYHAVKMIGWGNENNTDFWLIANSWHNDWGEKGYFRIVRGSNDCGIEGTIAAGIVDTESL
What is the function of this protein?
Expression of the protease correlates with blood-feeding and suggests a role for the protease in blood digestion.
What are the official names of this protein?
Cathepsin B-like cysteine proteinase 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: FPG_FRATT
Sequence: MPELPEVETVKRGLIKTIIDKKIFDIEINTDKLRYPIDKDQLVKIKNKVVKEIQRRGKHLIIFIEDDLQLIIHLGMSGIIKVIDSTNYNKIKHDHIVVTLSDNLSLVYNDPRKFGYWLVNTNHTPLEHRVLVSHGVEPLTADFNSDYLVSKLKQTSRKIKQTIMDNNIVVGVGNIYASEALFDSNILPTRASNTITKKEAANLVSSIKKILEKAITQGGTTLKDYKNTEGKPGYFTQQLNVYGRNEQQCYVCNTKIQSLVIAQRNTFFCKKCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: AROG_BACSU
Sequence: MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVNRFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKPEDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSPYDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELLKAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDISAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDSAQQMAIPEFEKWLNELKPMVKVNA
What are the official names of this protein?
Protein AroA(G).
What is the protein family that this protein belongs to?
Belongs to the class-I DAHP synthase family.
Protein: CYO7_VIOOD
Sequence: SIPCGESCVWIPCTITALAGCKCKSKVCYN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cycloviolacin-O7.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.