PharMolix/UniProtQA huggingface dataset:
Protein: GLYA_SHELP
Sequence: MLKKEMNIADFDPQLFQAIQEETRRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEHVDIVENLAIERAKELFGATYANVQPHSGSQANSAVYMALLQPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDESGKIDYDEMERLAVEHKPKMMIGGFSAYSGIVDWARMREIADKIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTSTTHKTLAGPRGGIILSAANDEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALSPEFKEYQQQVVVNAKAMANTFIERGFDVVSGGTENHLFLLDLIAKDITGKDADAALGRANITVNKNSVPNDPRSPFVTSGLRIGSPAITRRGFKEAEAVELTNWICDVLDDINNEATIERVKNQVLELCAKFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGRD2_HUMAN
Sequence: MDAPWGAGERWLHGAAVDRSGVSLGPPPTPQVNQGTLGPQVAPVAAGEVVKTAGGVCKFSGQRLSWWQAQESCEQQFGHLALQPPDGVLASRLRDPVWVGQREAPLRRPPQRRARTTAVLVFDERTADRAARLRSPLPELAALTACTHVQWDCASPDPAALFSVAAPALPNALQLRAFAEPGGVVRAALVVRGQHAPFLAAFRADGRWHHVCATWEQRGGRWALFSDGRRRAGARGLGAGHPVPSGGILVLGQDQDSLGGGFSVRHALSGNLTDFHLWARALSPAQLHRARACAPPSEGLLFRWDPGALDVTPSLLPTVWVRLLCPVPSEECPTWNPGPRSEGSELCLEPQPFLCCYRTEPYRRLQDAQSWPGQDVISRVNALANDIVLLPDPLSEVHGALSPAEASSFLGLLEHVLAMEMAPLGPAALLAVVRFLKRVVALGAGDPELLLTGPWEQLSQGVVSVASLVLEEQVADTWLSLREVIGGPMALVASVQRLAPLLSTSMTSERPRMRIQHRHAGLSGVTVIHSWFTSRVFQHTLEGPDLEPQAPASSEEANRVQRFLSTQVGSAIISSEVWDVTGEVNVAMTFHLQHRAQSPLFPPHPPSPYTGGAWATTGCSVAALYLDSTACFCNHSTSFAILLQIYEVQRGPEEESLLRTLSFVGCGVSFCALTTTFLLFLVAGVPKSERTTVHKNLTFSLASAEGFLMTSEWAKANEVACVAVTVAMHFLFLVAFSWMLVEGLLLWRKVVAVSMHPGPGMRLYHATGWGVPVGIVAVTLAMLPHDYVAPGHCWLNVHTNAIWAFVGPVLFVLTANTCILARVVMITVSSARRRARMLSPQPCLQQQIWTQIWATVKPVLVLLPVLGLTWLAGILVHLSPAWAYAAVGLNSIQGLYIFLVYAACNEEVRSALQRMAEKKVAEVLRALGVWGGAAKEHSLPFSVLPLFLPPKPSTPRHPLKAPA
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Adhesion G-protein coupled receptor D2, G-protein coupled receptor 144, G-protein coupled receptor PGR24.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AHR_DELLE
Sequence: MNSSSASITYASRKRRKPVQKTVKPVPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVVNKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRNGVQDNCRTKFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCPDSGQKMDEANGLSQPAVYYNPDQVPPENSSSMERCFVCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPTGCDAKGRIVLGYTEAELCMRGSGYQFIHAADMLYCAEYHIRMIKTGESGLIVFRLLTKDNRWTWVQSNARLVYKNGRPDYIIATQRPLTDEEGTEHLRKRNLKLPFMFTTGEAVLYEVTNPFPPIMDPLPIRTKNGAGGKDSATKSTLSKDFLNPSSLLNAMMQQDESIYLYPASSSTPFERNFFSDSQNECSNWQNNVAPMGSDDILKHEQIGQSQEMNPTLSGDHAGLFPDNRNSDLYSIMKHLGIDFEDIKHMQQNEEFFRTDFSGEDDFRDIDLTDEILTYVEDSLNKSALGCSGYHPQQSMALNPSCMVQEHLQLEQQEQRQQHQKHRAVEQQQLCQKMQHMQVNGMFANWSSNQSGPFNCPQPDLQQYDVFSDVPGTSQEFPYKSEIDTMPYAQNFIPCSQSVLPPHSKGTQLDFPIGDFEPAPYPTTSSNLEDFVTCLQVPQSQRHGLNPQSAIVTPQTCYTGAVSMYQCQPEAQHSHVAQMQYNPTVPGPQAFLNKFQNGGVLNETYPAELNSINNTQPTTHLHPSEARPFSDLTSSGFL
What is the function of this protein?
Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer.  Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE).  Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation.  Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene).  Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons.  Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists.  Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands.  Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity.  Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1.  Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1.  The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription.
What are the official names of this protein?
Aryl hydrocarbon receptor, Ah receptor, AhR.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
Protein: RIHC_ECO27
Sequence: MRLPIFLDTDPGIDDAVAIAAAIFTPELDLQLMTTVAGNVSVEKTTRNALQLLHFWNVDIPLAQGAAVPLVRAPRDAASVHGESGMAGYDFVEHNRKPLGIPAFLAIRDALMRAPEPVTLVAIGPLTNIALLLSQCPECKPYIRRLVIMGGSAGRGNCTPNAEFNIAADPEAASCVFRSGIEIVMCGLDVTNQAILTPDYLATLPELNRTGKMLHALFSHYRSGSMQSGLRMHDLCAIAWLVRPELFTLKPCFVAVETQGEFTSGTTVVDIDGCLGKPANVKVALDLNVKGFQQWVAEVLALVP
What is the function of this protein?
Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.
What are the official names of this protein?
Non-specific ribonucleoside hydrolase RihC, Purine/pyrimidine ribonucleoside hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihC subfamily.
Protein: MTF1_KLULA
Sequence: MTKSSFLKSVLPLANKIHTSYGSQFEKNPKVINQILDKLNLESYYKSESLQILDIYAGPLIQSVILNERLKPKKHVLLEDRLKFVELYQATLKDHPSMVNYNKNPYKWETFLEMTNEDRVLTPSMQKRDHIHNEFLIAANLTNKKGEQLYVQYLQCIANQNWMQRFGLVKMLVWIPQQTARKLFAPFSNKDRNRLTLLSELATNTKLVATSENSVKKFLPDCIEKFDPVIIPSDNKSPDDLSLVEINPRDHSIDLDHWDFVTQKLMILKSKPVEEMIEILGHGARDWFISRLDPVLLKKKPYELTYLEIDEIAKVFALWPFKPSLLVDFYDENED
What is the function of this protein?
Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase.  Interacts with DNA in a non-specific manner (By similarity).
What are the official names of this protein?
Mitochondrial transcription factor 1, Mitochondrial transcription factor MTTFB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UNG_STRPC
Sequence: MAHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPPRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGAYARKKKAFITNPKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUIX_ACIAD
Sequence: MRHFFKLGLVSAAVLGSQMTLANDFWSQDRQWLLGDWGGERQQLEKQGYKFTASIMSQAATNLDGGYNDSNTLENAGQLTLGANFDLSKIAGWEDTTAAIMITKRDGNSLTLERIKDPRSTTLGNTQEIYGRGKIWRLTQAWVKKGFNDNTVQFKIGRMGMSDDFNSSQCEFQNLLLCGGQLGKSIGSIWYNWPVGLWGTNVKYQFAPEWTLGLGVYEVNPDNVKTQSNSDGFNLDMNNVKGATIPVELAWKPKLAMFNGLPGEYKVGALYSTADANDVGTVSKVHDSKHSFWINTQQQLTQHNDNAKRGLFVSFNGVVNDKATTMVESTQQLALWYKGPFDSRPNDSIGFGLANYVVNKRVRDRQIATNESRGYYEYDDLASNYVPIQHDELNVELNYTYQWSPAVMLRPNIQYIHQPAGVKEVDDAWVAGLSMRLNF
What is the function of this protein?
Could be involved in the transport of quinate or shikimate.
What are the official names of this protein?
Putative porin QuiX.
What is the protein family that this protein belongs to?
Belongs to the OprB family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: LYSC_LYSEN
Sequence: GVSGSCNIDVVCPEGNGHRDVIRSVAAYSKQGTMWCTGSLVNNSANDKKMYFLTANHCGMTTAAIASSMVVYWNYQNSTCRAPGSSSSGANGDGSLAQSQTGAVVRATNAASDFTLLELNTAANPAYNLFWAGWDRRDQNFAGATAIHHPNVAEKRISHSTVATEISGYNGATGTSHLHVFWQASGGVTEPGSSGSPIYSPEKRVLGQLHGGPSSCSATGADRSDYYGRVFTSWTGGGTSATRLSDWLDAAGTGAQFIDGLDSTGTPPV
What is the function of this protein?
Highly specific endopeptidase that hydrolyzes lysyl bonds including the Lys-Pro bond.
What are the official names of this protein?
Lysyl endopeptidase, Lys-C.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SQUS_SALTY
Sequence: MKWFNTLSHNRWLEQETDRIFNFGKNAVVPTGFGWLGNKGQIKEEMGTHLWITARMLHVYSVAASMGRPGAYDLVDHGIKAMNGALRDKKYGGWYACVNDQGVVDASKQGYQHFFALLGAASAVTTGHPEARKLLDYTIEVIEKYFWSEEEQMCLESWDEAFSQTEDYRGGNANMHAVEAFLIVYDVTHDKKWLDRALRIASVIIHDVARNGDYRVNEHFDSQWNPIRDYNKDNPAHRFRAYGGTPGHWIEWGRLMLHLHAALEARFETPPAWLLEDAKGLFHATIRDAWAPDGADGFVYSVDWDGKPIVRERVRWPIVEAMGTAYALYTLTDDSQYEEWYQKWWDYCIKYLMDYENGSWWQELDADNKVTTKVWDGKQDIYHLLHCLVIPRLPLAPGLAPAVAAGLLDINAK
What is the function of this protein?
Catalyzes the isomerization of sulfoquinovose (SQ) to 6-deoxy-6-sulfo-D-fructose (SF) (By similarity).  In vitro, can also catalyze the interconversion of mannose, fructose and glucose, but has extremely low activity with glucose (PubMed:18328504).
What are the official names of this protein?
Sulfoquinovose isomerase, SQ isomerase.
What is the protein family that this protein belongs to?
Belongs to the N-acylglucosamine 2-epimerase family.
Protein: RS24_METTH
Sequence: MEINIIEEKENPLLNRKEIRFECLYEGESTPKVLEVKNKLVAMLDADKDLLVVDKIDQGFGEPRATGYAKIYESAEKLTEIEPEHVIKKNTEASEEEEEE
What are the official names of this protein?
30S ribosomal protein S24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: PUR9_SHESH
Sequence: MNNARPIRRALLSVSDKTGILEFAKSLHAQGVELLSTGGTARLLADNGVPVIEVSDHTGHPEIMDGRVKTLHPKVHGGILARRGIDELVMEQNNIKPIDLVAVNLYPFAETVAKEGCTLADAVENIDIGGPTMVRSTAKNHKDTTIIVNASDYDRVIVEMNANEGSTTLETRFDLAIAAFEHTAAYDGMIANYFGTQVPAHSKDECHHDSKFPRTYNTQLVKKQDLRYGENSHQTAAFYVDSPSFNGQGDEASVASAIQLQGKALSYNNIADTDSALECVKEFSEPACVIVKHANPCGVAIGSDLLDAYNRAFKTDPTSAFGGIIAFNGELDAATASAIVERQFVEVIIAPKVSQAARDIVAAKANLRLLECGEWNTKTTSLDYKRVNGGLLLQDRDQGMVGLDDVKVVSKRQPTAAEMKDLMFCWKVAKFVKSNAIVYAKDSMTIGVGAGQMSRVYSAKVAGIKAADEGLEVQDSVMASDAFFPFRDGIDAAAAAGISCIIQPGGSIRDEEIIAAADEHGMAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: SYQ_YERPA
Sequence: MSEAEARPSNFIRQIIDEDLASGKHTSVHTRFPPEPNGYLHIGHAKSICLNFGIAEDYQGQCNLRFDDTNPVKEDVEFVESIKRDVEWLGFTWSGDVRYSSDYFDQLYQYAVELINKGLAYVDELTPEQMREYRGTLTAPGKNSPYRDRSVEENLALFEKMRAGGFAEGTACLRAKIDMASPFIVMRDPVLYRIKFAEHHQSGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNISIDCHPRQYEFSRLNLEYTIMSKRKLNQLVTEKVVEGWDDPRMPTISGLRRRGYTAASIREFCRRIGVTKQDNNVEMMSLESCIRDDLNEHAPRAMAVLDPIKVVIENRAAGEEWLTMPNHPNNPEMGSRQVPFDSEIYIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNVTTLYCSYDAETLNKDPADGRKVKGVIHWVSVAHALPAEIRLYDRLFNVPNPAAAEDFLSTINPESLVIRQGFVEPSLADAVSDKTYQFEREGYFCADSRYSRPGALVFNRTVGLRDTWAAKATQ
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUTF_SERP5
Sequence: MQSQTLLADTPLQSPYVEKQDFRDAMARLGSAVNIITTDGPAGRAGFTASAVCSVTDTPPTLLVCLNRSASVYSVFKQNQTLCVNTLAAEHESLSNLFGGKTPMELRFSAARWSTLATGSPILHGAVVSFDCQIGQIVSVGTHDIFFCQALALTRNDDSHGLAYFDRRYHSLLKQ
What is the function of this protein?
Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.
What are the official names of this protein?
FMN reductase (NADH) RutF, FMN reductase, NADH-flavin reductase RutF, NADH:flavin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
Protein: MUTS_EHRRG
Sequence: MTNSNSITPVMQQYVTLKQQYKEYLLFYRLGDFYELFFDDAIKTSKILNIVLTKKGNVPMCGVPFHSSETYLNKLVKLGYKIAICEQLETSEEARKRGYKSLVKRDVVRIVTPGTIVEDSLLEAKESNYLACIVRIKDSCAIAWLELSTGLFCYHMTHISKLDSDLLRIGPKELLVADDLLEIEAVYSIIKKYRFSITQYSSSFFDENRAYNTLCNVYGVSTLKGLGDLKGVEISVCGSLLEYVIATQKGSLPKLGFPKAYVQSDFMFIDAAALRNLELFSTQSGELEGSLIASIDFTVTASGGRLLKRCLSAPLASADAINRRLSAVEFFVNNQNLYKSVRQVLRGIADIERILTRVKIARCSPKDLYSLKLTLEKTYELVELLCKFNIDIISEFCSRLGRYEDLICILNNSLLQNSVSSVKDGGFINPECDAQLSEYIYIQECSNQLIQELRDRYRNITNIQSLKILYNNILGYYVEVSSNHLIDDKNFIHRQSLANNVRYTTTELKELESKIISAKDASISLEIKIFGQLCSDVIKYADKITITAHAIAEIDMLTSFAELAVQYSYSKPIIDDSYEFNIKKGKHPVVERNGKFITNDINLSSEQRVHLITGPNMAGKSTFLRQNALIGILAHIGSFVPAEYAHIGVIDKVFSRVGASDNIVCGYSTFMVEMIETAAVINQATERSFVILDEIGRGTGTYDGLSIAWSVIEQIHNVNKSRAIFATHYHELSKLDKYLKHIKCFCMKVEEWDGKVVFLHEIIPGASDKSYGIHVAKLAGFPQSVVNRAEYLMDKLKTNEDLLT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: KCY_FLAPJ
Sequence: MKKITIAIDGFSSTGKSTLAKQLANHLGYIFVDSGAMYRAITYYALQNEYINQDLFNKEKLIKNLPQIKLEFQFNPKLGFAEMYLNDANVEKEIRTIKVSNYVSQVAAISQVRAKLVEQQQQMGKNKGIVMDGRDIGTVVFPTAELKIFMTASAQTRAQRRYDEMSSNSENVSYDEVLKNVQERDFIDTHREDSPLVKANDAIEIDNSHLSREEQFKIVLDLVNNI
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOC_SHEPC
Sequence: MTDLKKAAQRAIELMDLTTLNDDDTDQKVIDLCHKAKTPAGNTAAICIYPRFIPIARKTLDEIGAEDIQIATVTNFPHGNDDIAIAVLETRAAVAYGADEVDVVFPYRALMEGNETVGFELVKACKEACGEVLLKVIIESGVLADPALIRRASELSIDAGADFIKTSTGKVPVNATLEAAEIMLTVISEKNTQVGFKPAGGVRDAAQAAEFLGVAERILGADWVSPRTFRFGASSLLNSLLHTLELADAPKPTQGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIF12_HUMAN
Sequence: MEERGSPDGDLARSLEQGPEGPETPIQVVLRVRPMSAAELRRGQQSVLHCSGTRTLQGGPEVAFRFGAVLDAARTQEDVFRACGVRRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQGEGVPVPPSLAGIMQRTFAWLLDRVQHLGAPVTLRASYLEIYNEQVRDLLSLGSPRPLPVRWNKTRGFYVEQLRVVEFGSLEALMELLQTGLSRRRNSAHTLNQASSRSHALLTLYISRQTAQQMPSVDPGEPPVGGKLCFVDLAGSEKVAATGSRGELMLEANSINRSLLALGHCISLLLDPQRKQSHIPFRDSKLTKLLADSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRVTTRPQAPKSPVAKQPQRLETEMLQLQEENRRLQFQLDQMDCKASGLSGARVAWAQRNLYGMLQEFMLENERLRKEKSQLQNSRDLAQNEQRILAQQVHALERRLLSACYHHQQGPGLTPPCPCLMAPAPPCHALPPLYSCPCCHICPLCRVPLAHWACLPGEHHLPQVLDPEASGGRPPSARPPPWAPPCSPGSAKCPRERSHSDWTQTRVLAEMLTEEEVVPSAPPLPVRPPKTSPGLRGGAGVPNLAQRLEALRDQIGSSLRRGRSQPPCSEGARSPGQVLPPH
What are the official names of this protein?
Kinesin-like protein KIF12.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: FOLD_CUPPJ
Sequence: MSAQLIDGNALAKQIRSEAAVRAARLTERGHQPGLAVVLVGEDPASQVYVRNKVKACEDNGFHSSLDRYPADLSEAELLARIDALNNDPKIHGILVQLPLPKHIDSHKVLEAIAPEKDVDGFHVANAGALMTGAPLFRPCTPYGCMKMLESISYPLRGARAVVVGASNIVGKPMAMLLLQAGATVTICNSKTRDIGAHTRDADVIVAAVGKRNLITADMVKPGAVVIDVGMNRDDNGKLCGDVDFAGVREVAGYITPVPGGVGPMTITMLLINTLEAAERAAG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PALB_ASPOR
Sequence: MSRPNASAQKSFITQALKAERDVSSATSQRQALEAAIDAAEHYMKALNLASVQKDKHALDAKCKEWLTRAEKIKESKDWQAAARFHDKTVPEPRLPVSTRKLTTREEIILLEGAKLNGFIFPPWSTSPGSDEFKREDGESPFTDKPDLHLSYPQRKVFDGWKRPSELLAKDTEDVYTKVVPVMSVPGKTDLVQDMLTDCSVVASLCATTSMLERGQCTHFLPMIYPSRGSSQPSPSGKYIFRFYFNGCFRKVIIDDRLPSSKTSRSLHVIDRKNPNFLWPALVEKAYLKLRGGYDFPGSNSGTDLWVLTGWIPEQVFLHNDDVTGDQLWKRLYRSFHQGDVLLTIGTGELTEREQRELGLVSEHDYAILDMKESKGRRQLLVKNPWAGADTAPGDNGSLSASQDLPHNPPSFEPGTFWMDCEKLLQHFENLYLNWNPEIFKYREDVHFTWDLNNGRGVAGCFVNNPQFAVSTENGGIVWLLLGKHFRTTGQPERPLDEYQANEESAFISIYVFNADGKRVSLSDGALHRGPYVDSPNTLMRLEMPPRTTYTVVVSEQSLPSLNQNFTLSAFSTCPVRMAKAQDKYMCVRKIQGSWTPSTAGGNAESSRYPLNPQFRLEIENDTDVSLLLECPNTELATHVKLFWSNGNRVSRVRSRDIIADSGDYRRGGSLVEKKALEPGSYTIVCSTFAPDQLGRFTLWVSSLVPCKTSPLPPEAAGRRTVISDIGVLPPGRDRMLASLQVPRLTRIKLITRSRQSIIGSHPVGPSPVLMTVELGQGPYKQILATSEDGTHSDAVSGVRVEDFDLQPGLEESGGIWIVIERIGGPGGQVEDHFEVEALAEERVEIGEWILEDA
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH.  Probably is the signaling protease that mediates the first proteolytic cleavage within the signaling protease box of pacC (By similarity).
What are the official names of this protein?
Calpain-like protease palB/RIM13, Cysteine protease palB.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
Protein: EF2_STAMF
Sequence: MVRYKQTMEILKIMRNLEQVRNIGITAHVDHGKTTLSDSLLAAAGIISEKIAGEALALDYLDVEQRRGITVKSANISLYHEYKGKPYVINLIDTPGHVDFSAKTTRAMRVIDGAILVVDAVEGVMTQTEMYLRAALEERVRPVLFINKVDRLIKELRLSPQEIQQRFVQIIKEVNQLIAMYADKEFKTKWQLDPAKGQVAFGSARDRWGFTVPMAKQKGIKFSDIVDLYKKGKEALPELQKLAPLHEAVLDMVVKFIPNPREAQKYRLPKIWHGDLNSEIGKAMLETDPNGPLVMLVNDVRIDPHAGLVATGRVFSGTLRAGEEVWLVNARMKQKVLQVSLYMGPYRELADEIVAGNIAAVLGLDKARAGETVVAVEYKDMMTPFEKLRMISEPVVTVAIEPKNPRDLPKLIDALHKLSIEDPSLVVRINEETGEYLLSGMGPLHIEIALTFLKENYGLDVIASQPIIVYRESIRDKSRVFEGKSPNKHNKLYISVEPLDEKTISLIHDGIITEDMDPKQRAKVLREEAGWPTDQARRIWAIDENINVFVDLTTGVQHLREVKDTIIQGFRLAMREGPLAMEPVRGVKVILHDAIIHEDPAHRGPGQIYPAVRNAIYAGMLTAKPTLLEPIQKLDIKAPMEYLGNITTIITKKRGKILQVLQQGAVARIIAEIPVAETFDLAEQLRGATAGKAIWGQEFSRWAPVPDSMLLDLVRKIRERKGLKPEPPRPEDFIGF
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_ANADE
Sequence: MKGKAGGKAADAAEKVAASNRRARFDYDIEDTWEAGLVLTGSEVKSLREGNVNLSDAYAMPRGEELWLLNCRIGEYKQAAHFGHAPLRDRKLLMNRAEIDRVRGKVEQRGYTLVPLRIYFKQGWAKVELGLARGRSHEDRRGAIAERESKREMDRALARGRRR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: VATD_BORBU
Sequence: MSKIKLTKNDLKKQKDELKMFKRYLPTLQLKKQQLYMEIVKIENSYKIKNLEQQKLKENISNWISLFSEKFPFESWIQVKTVVKKSLNIAGVAIPIFDSIEYEDIRHDLLFTPYWVDKGIEILKVVIQIDVELKILKKQIDLLLREFRITSQRVNLFEKVMIPTAKANIKKINIYLGDQQTAAVVRGKIAKSSLIKKNRNSL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: RL34_PETMO
Sequence: MKRTYQPSRIKRKRTHGFLARKRTSTGRNVLRRRRAKGRERLTV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: CVFB_STAES
Sequence: MALDKDIVGSIEFLEVVGLQGSTYLLKGPNGESVKLNQSEVAEEDDFELGEEYSFFVYPNRSGDLFATQNMPDITKDKYDFAKVIKTDRDGAHIDVGLPREVLVPWEDLPKLKELWPKAGDYLLVTLRIDSTNQMFGRLASETIVESMFTPVNDDSKQNEYISARAYRLLRVGSFLLSNEGYKIFVHESERKHEPRLGEAVEVRIIGHNEKGELNGSFLPLAHERLDDDGQVIFDLLVEYDGELPFWDKSSPDAIKEVFNMSKGSFKRAIGHLYKKKIINIETGKITLTKKGWSRVDD
What are the official names of this protein?
Conserved virulence factor B.
What is the protein family that this protein belongs to?
Belongs to the CvfB family.