PharMolix/UniProtQA huggingface dataset:
Protein: TRIM2_CALJA
Sequence: MASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNVEESSILETVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGVKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ
What is the function of this protein?
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11.  Plays a neuroprotective function.  May play a role in neuronal rapid ischemic tolerance.  Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity.
What are the official names of this protein?
Tripartite motif-containing protein 2, E3 ubiquitin-protein ligase TRIM2, RING-type E3 ubiquitin transferase TRIM2.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHB1_PANTR
Sequence: MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRVLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGPSAVGDPELGDPPAAPQ
What is the function of this protein?
Favors the reduction of estrogens and androgens.  Also has 20-alpha-HSD activity.  Uses preferentially NADH.
What are the official names of this protein?
Estradiol 17-beta-dehydrogenase 1, 17-beta-hydroxysteroid dehydrogenase type 1, 17-beta-HSD 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YK026_HUMAN
Sequence: MYWQNWTHNGRLWGAGVHLYLSRKQCALKNTSLSKFQTSHICKGSALQPQQASPGASSFLTCPELGVMYLKLVLGQMVQAVRRDSGLQPFGSLFLLITQKRAVLTPFLTKTWHSLRALVYRVWSLEESRYLQREKGLVDSFGVLWEE
What are the official names of this protein?
Putative uncharacterized protein LOC100129027.
Protein: MASTR_BOVIN
Sequence: MTLAASSQRSQIIRSKFRSVLQLRIHRRYQDPTLSGSFTASPVLDPDPWISAADPALALAPASPLGPAPFLFNPEVLLPEPKPCWSLKKESPKTSQHWREPKPKGNLTYHQYIPPEPRQGYRADPQVEGSPLDPPGPPLWEGTTSQQPPPRMKPTPLTPSPPGVPSPSPLPHKLELQTLKLEELTVSELRQQLRLRGLPVSGTKSMLLERMRGGAPPRERPKARREDSAAGAPWPRFRPKALGAARSACSFKLSPTSHSPPPPRAVETLVTASASAPVPVATTAQAPTPAPVPVPSSAPASTALTLEEELQEAIRRAQLLPNRGIDDILEDQVEPEDPLPAIPLDFPGSFDMLSPSPDSEGLSSVFSSSLPSPTNSPSPSPRGPTDFLDWLEALSGGPSLGCGPPAPSIFSADLSDSSGTRLWDLLEDPW
What is the function of this protein?
Transcriptional coactivator.  Stimulates the transcriptional activity of MEF2C.  Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity).
What are the official names of this protein?
MEF2-activating motif and SAP domain-containing transcriptional regulator, MEF2-activating SAP transcriptional regulatory protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: MBL2_HYLLA
Sequence: MSLIPSLSLLLMSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDCDSSLAVSERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEMMTFEKVKALCVKFQASVATPRNAAENRAIQNLIKEEAFMGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGLWNDVPCSSSHLAVCEFPI
What is the function of this protein?
Calcium-dependent lectin involved in innate immune defense.  Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.  Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
What are the official names of this protein?
Mannose-binding protein C, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin.
What are the subcellular locations of this protein?
Secreted.
Protein: PROQ_SALG2
Sequence: MENQPKLNSSKEVIAFLAERFPHCFSAEGEARPLKIGIFQDLVERVGGEMNLSKTQLRSALRLYTSSWRYLYGVKPGATRVDLDGNPCGELEEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAAAAGEKEDAPRRERKPRPVARRKEGAERKPRADKPTTKAPRAPREEKHTPVSDISVLTVGQSLKVKAGNNAMDATVLEITKDGVRVQLNSGMSLIVRAEHLVF
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.  May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YMID_ECOLI
Sequence: MQKLPLKEKCLTATANYHPGIRYIMTGYSAKYIYSSTYARFR
What are the official names of this protein?
Protein YmiD.
Protein: Y2415_RIPO1
Sequence: MTKIAYLECPSGIAGDMCLGSLVDSGVPLEYLIEQLKKLEIQDEYRLWSEKVYRQGQLATKVHVELVEHDPSNHPSQNTHHHHHHHTRHLPEIESMIKGANLPPQSREWSLAVFRQLAIAEGAVHGIEPEKVHFHEVGAIDAIIDIVGTCLGLDWLGIEALYCSEMPTGGGTVWAAHGRLPVPVPAVIKLWESRQVPVYSNNINKELVTPTGAAIAVTLAKHFGSPPAMKVQKIGLGAGSNELPIPNILRLWIGESNNPDQVQQLSEKIAVLETQIDDLNPQVIGYVFEALLAAGALDVFTQAIGMKKSRPGILLTVICTPEKVADCQNIIFKETTTLGIRHRIQNRSILQREIQQITTDYGVARVKIASQGIGDNKTILNVQAEYEDCVELALKSNQPLQIIQQIVLNTWYHQNCLKI
What are the official names of this protein?
Putative nickel insertion protein.
What is the protein family that this protein belongs to?
Belongs to the LarC family.
Protein: RECF_STRT2
Sequence: MWLEKIDIQHFRNYSEASVSFSPHLNIFLGRNAQGKTNILEAIYFLALTRSHRTHLDKELIQFQQNSLKLNGIVHRHSGNLPLEINLSNKGRVTKVNYLKQAKLSDYIGHMTVVLFAPEDLQLVKGSPSLRRKFIDIDLGQIKPVYLSDLSNYNHVLKQRNAYLKSTDKVDINFLSVLDEQLADFGARVIKHRLEFIKQLEEEADGHHSILSNQIERLKISYESNIPIQNSKDIREAFLTILNQNHKRDIFKKNTGVGPHRDDLKFYINDMNASFGSQGQQRSLILSLKMAEIALIKKVTEEFPILLLDDVMSELDNHRQLKLLESIDEEVQTFMTTTSLDHLSNLPPNLKTFLVKNGTIYEKQVD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP68_RAT
Sequence: MLQSFIKKVWVPMKPYYTQVYQEIWVGVGLMSLIVYKIRSADKRSKALKGCSPAHAHGHH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Minor subunit required to maintain the ATP synthase population in the mitochondria.
What are the official names of this protein?
ATP synthase subunit ATP5MPL, mitochondrial, 6.8 kDa mitochondrial proteolipid protein, MLQ, ATP synthase membrane subunit 6.8PL.
What is the protein family that this protein belongs to?
Belongs to the small mitochondrial proteolipid family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: MD20A_ARATH
Sequence: MPVKWVLHWQPNQGSTVSSQILNEATQCVESINGVKEGRWKATLNYYKPMLKDQANQLEFPRDFLGISLADQPNKYYFIIRTQRIVLEADSSIQLIMEKLQSYKSKVALYFDGFQYQLGDFRLRVGKVVPTHSENVRGIVMEVEYLPISSMEKAQKVMEEFLEIWNEALAKRSLPGKFVNIDLNFGEFGLGDIYTPQHTAVRYALVMAHMIATVQAVRG
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 20a.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 20 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NEP_I49A0
Sequence: MDSNTITSFQDILQRMSKMQLESSSVDLNGMITQFERLKIYRDSLGESVMRMGDLHSLQNRNATWREELSQKFEEIRWLIAECRNILTKTENSFEQITFLQALQLLLEVESEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: ATG12_EMENI
Sequence: MSSPSSRISSINNSPNPNLRKPSSRRESLDQPSNAQNAPIPDDEHGADLPLTMSASVVLTSLPRDAHQALADAEAIDTGKVTVRFQPLASAPILKNRVFKISASQKFETVVNFLRKKLNCKDTDSVICYVNSVFAPRLDEGVGGLWRCFKTDDQLIVAYSMTPAFG
What is the function of this protein?
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.  Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function.  The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
What are the official names of this protein?
Ubiquitin-like protein ATG12, Autophagy-related protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG12 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: ATPF_CHLPM
Sequence: MLMSAVILLSGSLLDPNPGLIFWTAITFVLVLLILKKIAWGPILGALEEREKGIQSSIDRAYGAKEEAEAILRQNKETLAKAEAESDRIIREGREFADKIRAEITEKAHTESQKMIGAAKDEIEQEKRRALDVLRNEVADLAVRGAEKIIRASLDGEVQRKVVDSMIADLSTKQN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: COAD_STAAM
Sequence: MEHTIAVIPGSFDPITYGHLDIIERSTDRFDEIHVCVLKNSKKEGTFSLEERMDLIEQSVKHLPNVKVHQFSGLLVDYCEQVGAKTIIRGLRAVSDFEYELRLTSMNKKLNNEIETLYMMSSTNYSFISSSIVKEVAAYRADISEFVPPYVEKALKKKFK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM260_MOUSE
Sequence: MGLHGDGGSPAAGAGPWRSGALRGSVAVFASVAAVFTLTLPRSLPGGDSGELITAAHELGVAHPPGYPLFTLLASLTITLFPFGSVAYRVNLLCGLFGAVAASLLFYTVFRLSGSHAGGILAAGVFSFSRLTWQWSIAAEVFSLNNLFVGLLMALTVRFEEATAAKERSKIAAIGAFSCGLSLCNQHTIVLYILCIIPWILFRLLKEKELTLSLLLRLTLAFSAGLLPYVYLPVSSYLSRARWTWGDQTTLRGFLTHFFREEYGTFSLAKSEVGSSVSTVLLSQVINMKTELSFNIQALAVWANICLARKDRRKSSVVWLFTGMLCLYSLFFAWRANLDISKPLFMGVVERFWLQSNAVVAVLAGLGLATLVSETNRVLHCTGIRNLEWLSAALFVAYQVYSNYSICDQRTNNVIDQFARNLLDSMPQDAIILLRGDLPGNALRYLHYCEGLRPDVSLVDQEMMTYEWYLPKMARHLPGVHFPGDRWNPVEGVLPSGMVTFNLYHFLEMNKQKETFVCIGIHEGDPTWKKDYSLWPWGSCDKLVPSKIVFNPEEWIERTRAIYNWTEAYERFGPSSWESVANEEMWQARMKTPFFIFSLAESAAVPADVKAQLYTHAYKLYKEIVYLQEEHPVNWHKNYAIACERMLRLPGTGIDPEVLLSEAIRHFHLYTQKAQNDPQRADIIAALKHLRRELQSLRNIKKV
What are the official names of this protein?
Transmembrane protein 260.
What is the protein family that this protein belongs to?
Belongs to the TMEM260 family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Note=Shows strong localization in the vicinity of the cell membrane.
Protein: ARR1_CALVI
Sequence: MVVNFKIFKKASPNNMVTLYMNRREFVDSVTQVEPVDGIVVLDDEYIRQNRKIFVQLICNFRYGREDDEMIGLRFQKELILVSQPVYPEQKIDIQLTKMQERLLKKLGSNAYPFILEMPPSSPASVVLQQKANDSTQPCGVQYFVKVFAGENDCDRSHRRSTVNLGIRKVQYAPTKTGIQPCTVVRKDFLLSPGELELEVTLDRQLYYHGEKISINICVRNNSNKVVKKIKAMVQQGIDVVLFQNGQFRNTIAFAESSEGCPLNPGSSLQKIMYLVPNLAANCDRAGIAVEGDVKHKNTSLASTTLIASQEARDAFGIIVSYAVKVKLFLGALGGELCAELPFILMHPKPSLKAQPEAETEEA
What are the official names of this protein?
Phosrestin-2, Arrestin-1, Arrestin-A, Phosrestin II.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
Protein: SPRE_MOUSE
Sequence: MEADGLGCAVCVLTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAADLGTEAGVQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYWALNLTSMLCLTSGTLNAFQDSPGLSKTVVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAEEPSVRVLSYAPGPLDNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLGLLQKDTFQSGAHVDFYD
What is the function of this protein?
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
What are the official names of this protein?
Sepiapterin reductase, SPR.
What is the protein family that this protein belongs to?
Belongs to the sepiapterin reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_MYCBP
Sequence: MTVPAPSQLDLRQEVHDAARRARVAARRLASLPTTVKDRALHAAADELLAHRDQILAANAEDLNAAREADTPAAMLDRLSLNPQRVDGIAAGLRQVAGLRDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFGLTLKSGNAALLRGSSSAAKSNEALVAVLRTALVGLELPADAVQLLSAADRATVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTIETGVGNCHVYVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAETALPRLLAALQHAGVTVHLDPDEADLRREYLSLDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNLDAAQRFTEQIDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGAGHTRPA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPH_ECOLI
Sequence: MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRSETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFVCYAREQVMTILPDSPPRFINLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQFYPRMMAQASRKAL
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: ZNG1_YEAST
Sequence: MSALRNIKFNEEEDGELPCLVTGEENNLQEILENVSYDGGNIVSDAKVERVNKQVENTSAGATDVHEKKRIPVSIITGYLGSGKSTLLEKIALKGADKKIAVILNEFGDSSEIEKAMTIKNGSNSYQEWLDLGNGCLCCSLKNIGVKAIEDMVERSPGKIDYILLETSGIADPAPIAKMFWQDEGLNSSVYIDGIITVLDCEHILKCLDDISIDAHWHGDKVGLEGNLTIAHFQLAMADRIIMNKYDTIEHSPEMVKQLKERVREINSIAPMFFTKYSDTPIQNLLDIHAYDSVRISDILDSGSGNGTIHDDRMGTIMLTFRPLKNEEEYNNKFIKQFLQPLLWKNFGAMTVLGGRRRDDGRDWEVQRTKGLILIEGENPIARVIQGVRDTYDVFPGKYDGSNKECKIVLIGKYLEKESIEELLRKTLE
What is the function of this protein?
Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (PubMed:35584675).  Catalyzes zinc insertion into the active site of methionine aminopeptidase MAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584675).  Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of MAP1 (PubMed:35584675).  After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1 to the zinc binding site in the peptidase domain of MAP1 in a process requiring GTP hydrolysis (PubMed:35584675).  GTP/GDP exchange is required for release of active MAP1 (PubMed:35584675).
What are the official names of this protein?
Zinc-regulated GTPase metalloprotein activator 1.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
Protein: CH10_CHLPB
Sequence: MNLKPLADRVIVKPAPAEEKTKGGLYIPDTGKEKPQYGEVVAVGAGKVADSGQLLEMQVAVGNKVLYGKYSGTEVAVEGEDYLIMRESDIFAILD
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K2M1_SHEEP
Sequence: QNRQCCESNLEPLFSGYIETLRREAECAEADSGRLSSELNSLQEVLEGYKRRYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANVEALIQETDFLRRLYEEEIRVL
What is the function of this protein?
Wool microfibrillar keratin.
What are the official names of this protein?
Keratin, type II microfibrillar, Low-sulfur keratin.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: PCDA6_PANTR
Sequence: MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPNFEQSEYEVRIFENADNGTTVIKLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQENFYKIRIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSVGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGAAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPSTEGACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEGPPKMDLMAFSPSLSPCPIMMGKAENQDLNEDHDAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin alpha-6, PCDH-alpha-6.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: TRUB_ALKOO
Sequence: MNGILNILKPPGMTSHDVVSVVRKKLNMKKVGHTGTLDPNAAGVLPICIGQATKISQFLLDGKKKYRAELTLGIETNTEDIDGEILRQREVTSSPDEIREAVLSFIGEYKQIPPMYSAIKIKGKKLYELARQGVEIERAERTVTIYHIEIIEIFKEKVIFDVLCSKGTYIRTLCKDIGEVLGCGGVMSFLLRTASSDFSLDTAITIEELQALENVEDILLPMDYPLQHMSKAIVKSAYSKQVLNGNRIYSNYLIDTIHEPIGQEVCVYLEKEFVGFGIVRNEDHNQKYIKILRLLFEKE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: SYH_TOLAT
Sequence: MAKQIQAIRGMNDCLPEQTPVWQMVEATLRRVVSSYGYSEIRMPVVEMTNLFQRAIGEVTDVVEKEMYTFNDRNGDSLTLRPEGTAGCVRACIEHGLVYNQERRLWYVGPMFRHERPQKGRYRQFHQFGVEVFGLTGPDIDAELIMMTARLWRELGIAQFTTLQLNTLGSSAERAAYRDALVTFLEQHKESLDEESQRRMYSNPLRVLDTKNPQVQEILQHAPTMADYFGEETKAHFSGLKALLDAAGIAYQVNERLVRGLDYYNYTVFEWVTDSLGAQGTICGGGRYDGLVEQLGGQATPAIGFAMGLERLTLMLETLEQIRNIPSTVDVYICMAGEGTLTAGLLLAEKLRSERPQLRVMTHCGGGNFKKQMKRADKVEARIALILGETEVAEQKVTVKFLRDQVEQQTVDVTALLPILAQLGE
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FB343_ARATH
Sequence: MLSTENPNSSPLSDSLEFNERHLDSIISSLVTFPDSPSLSISSSFDRVLDHLLSSGDVSVQDQLVDRTLERFSLLLQSTKRCSQKRATLHNSISWFLPSELTVKVFSMVDTKSLMQASACCTMFNNCAMDPLCYFHIDLTKAFKHVDDRVLRTLLNRSGKQLRSLKLGRVDAPGCLFRSSCLPPLILYGNNARRALKLGRDPPGLGSLFTRSCFDPLKLTGNLLTSLHIYSLGFMNMNSFLDPLSACSNLTDLKIVGVNVLLEPILELLARNCCLIEHLFLDNCSQGKTFTWWGFLYFTVA
What are the official names of this protein?
F-box protein At4g02733.
Protein: VINC_HUMAN
Sequence: MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ
What is the function of this protein?
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion.  Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex.  May also play important roles in cell morphology and locomotion.
What are the official names of this protein?
Vinculin, Metavinculin, MV.
What is the protein family that this protein belongs to?
Belongs to the vinculin/alpha-catenin family.