PharMolix/UniProtQA huggingface dataset:
Protein: FLIT_SALPC
Sequence: MTSTVEFINRWQRIALLSQSLLELAQRGEWDLLLQQEVSYLQSIETVMEKQTPPGITRSIQDMVAGYIKQTLDNEQLLKGLLQQRLDELSSLIGQSTRQKSLNNAYGRLSGMLLVPDAPGAS
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TAF1B_MOUSE
Sequence: MDVEEVKAFRDRCSQCAAVSWGLTDEGKYYCTSCHNVTDRSEEVVSAADIPNTKINSINRGLRQRSKHEKGWDWYVCEGFQCILYHQAKALETLGVSPELKNEVLHNFWKRYLQKSKQAYCKNPVRTSGRKAKVLEDSVQSSDLGSDLELLSDTTCPLESEAEFQSDPQIPKPFPVTKGSPKSASVCSGSVDGVEYSERKEKGLVKMTVPRTLALCSLSLLWQRETITVSDLLRFVEEDHIPYINAFKLFPEEMKVYGRDKGIFAIESWPDYEDIYKNMIELAIFLDLPRFPDITEDCYLHPNTLCMKYLLEVNLPDEMHTLTCQVVKLTGIGEVDFLTFDPIAKTKRTVKYDVQAMAVIVVVLKLLFLLDDKLEWSYSDLAEAYNEQHREDTPQFDFRKWYQVMKKTFDEKRRKWEEARARYAWKTKRPLYRSHIDKSVAYKRRKMVENLQKQFSALVGSSPVVEKQAPSSFQFNWTEEGTDSPCFHGHSLQGLLIMKGQSMITKNSLYWLSTQKFCKSYCKHVTTYEESNFSLSYQFILNIFSFLLRIKTSALHEEVSLLEKKLFEKKYNESKKSSGSKKGRRH
What is the function of this protein?
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription.  Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
What are the official names of this protein?
TATA box-binding protein-associated factor RNA polymerase I subunit B, RNA polymerase I-specific TBP-associated factor 68 kDa, TAFI68, TATA box-binding protein-associated factor 1B, TBP-associated factor 1B, Transcription initiation factor SL1/TIF-IB subunit B.
What is the protein family that this protein belongs to?
Belongs to the RRN7/TAF1B family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MSD2_AMAFL
Sequence: MSDINATRLPHLVRYPPYVGDGTDLTLNRGEK
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:24613547).
What are the official names of this protein?
MSDIN-like toxin proprotein 2.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: Y4171_RHOPS
Sequence: MAGHSQFKNIMHRKGKQDAQRSKAFSKLAREITVAAKLGTPDPAMNPRLRAAVIAARQENMPKDNIERAIKKAIGGDSENYDEIRYEGYGPGGVAVIVEALTDNRNRAASDIRSYFTKSGGNLGETGSVSFMFDRTGVIEYDAGKASADDMLDAAIEAGADDVLSSEGGHEVFASQETFRDVAKALEAKFGEPRKAALIWKPQNTVAVDDETGEKLFKLMEHLNEHDDVQNVYANFEVSDALMAKMAG
What are the official names of this protein?
Probable transcriptional regulatory protein RPD_4171.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIW_MAGMM
Sequence: MEIQGTRFGTLEFDEKEIIYLNEGLLGFPLSKQFLMFPYGEDSSFFWLQSVDEPEIAFIVINPFDFFSDLEFAVEDEDASSLVLARSEDVEIFTLVTIPEGRPEEMRTNLAGPVVVNVQNRLGKQILCKDYSPRQPLIPDSMRSQLKEQARSSKGGHVAGGR
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_MYCBT
Sequence: MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: PUR7_WOLWR
Sequence: MSLNKTIYEGKAKAIIETEDSSTVIQHFKDDVTAFNKEKYEIIESKGIINNHISAFIMEKLEKAEISTHFIKTLNEREQLVKKLKIIPLEVVVRNVAAGSFCKRFNIKEGERLASPIIDFFYKNDDLADPMVSENHILYFDWLSSKEMDEVKTTTLKINEILVHLFSNASIYLVDLKLEFGRLINDSTKIVLADEISPDNCRLWDKNTYKKLDKDVFRLNLGDLKEAYLEVAKRLSVKLG
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: PHS_NOSP7
Sequence: MTQLLTKTEIQEQAKVLSGWTVEESKLHITRTFKDFIQAIEFVNKLVEPAESAGHHPDIKISYNKVKITLTTHDAGGLTQADFDVAQTISQIK
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: RL31_MAGMM
Sequence: MKEGIHPKYEEATFTCASCSNEIKTRSTAGDLTLGICSECHPFYTGKHKLVDTAGRVERFRRKYGMQDQ
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: NDUA2_ARATH
Sequence: MAWRGSISKSMKELRILLCQSSPASAPTRTFVEKNYKDLKSLNPKLPILIRECSGVQPQMWARYDMGVERCVNLDGLTEPQILKALENLVKSGATKA
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA2 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: LIPB_PSEPK
Sequence: MMSACLGFRELGLQPYEPVLEAMRRFTEQRSPDSQDEIWLVEHPAVFTQGQAGKAEHLLVPGDIPVVQTDRGGQVTYHGPGQLVAYLLLDVRRLGFGVRELVSRIELALIDLLASYAVQASAKPDAPGVYVDGAKIASLGLRIRNGRSFHGLALNVDMDLAPFRRINPCGYAGLAMTQLRDLAGPIELDEVRTRLRGQLVKHLDYAEQTTLTGGID
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSRA_CAMJ8
Sequence: MLILSRKENESIIIGEGIEIKVVQTGKGYAKIGIEAPKSLMILRKELVQQVKDENLHSVVQNDIKLDDLSKKLIK
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its function is probably anatagonized by FliW.  Inhibits translation of flaA mRNA in vitro (PubMed:27353476).  Involved in post-transcriptional regulation of flagellin biosynthesis (PubMed:27353476).
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_PSEAE
Sequence: MAILNILEFPDPRLRTIAKPVEVVDDAVRQLIDDMFETMYEAPGIGLAATQVNVHKRIVVMDLSEDKSEPRVFINPEFEPLTEDMDQYQEGCLSVPGFYENVDRPQKVRIKALDRDGNPFEEVAEGLLAVCIQHECDHLNGKLFVDYLSTLKRDRIRKKLEKQHRQQA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: MUTS2_STRA1
Sequence: MNNKILEQLEFNKVKELILPYLKTEQSQEELSELEPMTEAPKIEKSFNEISDMEQIFVEHHSFGIVSLSSISESLKRLELSADLNIQELLAIKKVLQSSSDMIHFYSDLDNVSFQSLDRLFENLEQFPNLQGSFQAINDGGFLEHFASPELERIRRQLTNSERRVRQILQDMLKEKAELLSENLIASRSGRSVLPVKNTYRNRISGVVHDISSSGSTVYIEPRAVVTLNEEITQLRADERHEESRILHAFSDLLRPHVATIRNNAWILGHLDFVRAKYLFMSDNKATIPEISNDSTLALINVRHPLLSNPVANDLHFDQDLTAIVITGPNTGGKTIMLKTLGLAQLMGQSGLPVLADKGSKIAVFNNIFADIGDEQSIEQSLSTFSSHMTHIVSILNEADHNSLVLFDELGAGTDPQEGASLAMAILEHLRLSNIKTMATTHYPELKAYGIETNFVENASMEFDAETLSPTYRFMQGVPGRSNAFEIASRLGLAPFIVKQAKQMTDSDSDVNRIIEQLEAQTLETRRRLDHIKEVEQENLKFNRAVKKLYNEFSHERDKELEKIYQEAQEIVDMALNESDTILKKLNDKSQLKPHEIIDAKAQIKKLAPQVDLSKNKVLNKAKKIKAARAPRIGDDIIVTSYGQRGTLTSQLKDGRWEAQVGIIKMTLTQDEFTLVRVQEEQKVKSKQINVVKKADSSGPRARLDLRGKRYEEAMQELDNFIDQALLNNMGQVDIIHGIGTGVIREGVTKYLRRNKHVKHFAYAPQNAGGSGATIVTLG
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: TRMD_RHIL3
Sequence: MMAFRASVLTLYPEMFPGHLGFSLAGKAMERGQWSLDTVQIRDFATDRHRTVDDTPAGGGAGMVLKADVLARAIDSASETDTRPRLLMSPRGRPLTQERVRELAAGDGVIIVCGRFEGVDQRVIEARGLEEVSIGDYVLSGGEPAALTVLDAIVRILPGVMGNDLSGLHESFEGGLLEHPHYTRPQEWEGREIPAILTSGNHGAIEKWRHQEAVRLTRERRPDLLEKAGASPGKSGSNFGKHDA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_EHRRW
Sequence: MYGWINIDKPCGISSASVVSRVKKILNVKKVGYAGTLDPLASGILPIAIGEATKLMPYAVDVQKSYIFTVQWGEQRTTDDASGEIIKKSNIVPHFEEINKIIPNFIGMIEQVPPNFSAIHVDGVRAFKLARNGQEFELSSRYVNVVRLKLLSFSRENNTADFYLLCKKGVYVRSIARDLGIRLGCFGYVAKLRRVRVGYFKQKNAITLDKLKILHNNGDTHKYLLPLWYVLQDIKHLDDVFCSVEISKIKNGQNIQLNNLYMVKNCDMCYVSTHSVPVAICSIANNVIKPVRVFNV
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: ATPG_TRIL1
Sequence: MASLKSIKKRIVSVKNTRQITKAMKMVSAAKLRRAQENVVAARPYAQKMGEVLQSLAGNLEGNLHPLLEKRDAKKLLLIVVTSDRGLCGGFNTNLCKAGERYIKEKQAEFDQISIMTVGRKGYEFLKSRHTVYKNFANMLSKPNYQAAAMLAQDVIEGYLAEEYDQVVMLFNSFRTVMSQDITFQQLLPIEPEEKIAADENGVEYIYEPSVSDLLTEILPKNIEVQIFKAMLESVAGEHGARMTAMDSASKNASEMIGKLTLQYNRARQAAITTELMEIISGAESIKG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DBP4_PICST
Sequence: MAKPRRNNKNKKGQSRSQAREKEEAELLKLQERIDQYDPAVDEKSISQFSDLPITQETLRGLNESSFMSLTDIQKKTIPIALKGEDLMGTARTGSGKTLAFLIPVVESLIRNKITEHDGLAALIVSPTRELAVQTFEVLTKIGKYNTFSAGLVTGGKDVQYEKERVSRMNILVGTPGRISQHLNEAVGMETSNLQVLVLDEADRCLDMGFKKQIDNIVGHLPPTRQTLLFSATVSDSVKDLARLSLTNPKRIGVSSDQDVSATPESLDQYYIRIPLDEKLDVLWSFIKSHLKSKILVFFSSSKQVQYAYETFRTLQPGISLLKLYGRHKQTSRLETTVKFTQAQYACLFATDIVARGLDFPAIDWVVQVDCPEDAVTYVHRVGRAARFGRQGKSLLMLLPSEEEGMLKRLENNKIEPKFMNIKQKSKKSIRPQLQSLCFKDPMIKNLGQRAFISYYKSVYIQKDKDVFKVEELPSEKYAASLGLPGAPKIKIKGGSSSKEKKNASRQLVALSKTNEDGESVENEASKVRTKYDRMFERKNQNVLSEHYLKLNGSQTKEDEDEEEEDDFMSVKRKDHELTEVELPDLTIPVSKRQAKKALSKKLSISTKGNPTKLKFDDEGVAHAIYELEDEEDFIKRGDAKEQKKAFVSRETEVMNEADEEDKIMAKEKRQEKKRKRKEVEKRMRDEELQSGDDEETVYTLGGDVDLERDMEYSTDEEEQPQNKKPKWFENDKHNRKNPVNHIVEIDEPETLEDLESLTARLLQH
What is the function of this protein?
ATP-dependent RNA helicase required for ribosome biogenesis.  Involved in the release of U14 snoRNA in pre-ribosomal complexes.  Required for pre-rRNA cleavage at site A2 (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HYP1_DAVTA
Sequence: MAFIKSLLIASVAAVAFAAPQGGASDNNKKVEIDGQDSAPVCGNGQKVACCNSGEDLIGLNCLSIPILAIPIQKACGSNIAACCQTGDSEGNLLNLEANCLAIPL
What are the official names of this protein?
Hydrophobin-1.
What is the protein family that this protein belongs to?
Belongs to the fungal hydrophobin family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: CCNJL_HUMAN
Sequence: MMDEPWWEGRVASDVHCTLREKELKLPTFRAHSPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKQLYTVAVSCLLLANGVSLLSPRLKCSGMISAHCNLHLPGSSNSPASAPHPPPTPPQVAETTGKFEDREDHVPKLEQINSTRILSSQNFTLTKKELLSTELLLLEAFSWNLCLPTPAHFLDYYLLASVSQKDHHCHTWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISSYSLEHLSTCIEILLVVYDNVLKDAVAVKSQALAMVPGTPPTPTQVLFQPPAYPALGQPATTLAQFQTPVQDLCLAYRDSLQAHRSGSLLSGSTGSSLHTPYQPLQPLDMCPVPVPASLSMHMAIAAEPRHCLATTYGSSYFSGSHMFPTGCFDR
What are the official names of this protein?
Cyclin-J-like protein.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin J subfamily.
Protein: UBC1_SCHPO
Sequence: MSDNRSRRIAKELADVQQDKQAGIQVWTINDDISHLKGMFRGPEGTPYEGGYFVVDIEIPIDYPFRPPKMNFDTKIYHPNVSSQTGAICLDILKDQWSPVYTMKSALISLQSLLCTPEPSNPQDAQVAQVYLQNYQQFVRTAREWTSSYAAAPAGVDLDAENTEFGGIDPNIITNLQQFGFSTELIVRVLQREHIKSQEDLKDYPNGINGILDQLLH
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system.  Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 1, E2 ubiquitin-conjugating enzyme 1, Ubiquitin carrier protein 1, Ubiquitin-protein ligase 1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LSRA_YERPG
Sequence: MPHTVATPPPLLQVRGISKQFSGVVVLKSIDFTLQPGQVHALLGGNGAGKSTLMKIIAGILPPDTGVIEMNGQPCFNLTPAKAHQLGIYLVPQEPMLFANLSVQENILFRLPKHQADKKKMAQLLKNLGCHLDLSVSAGSLEVADQQLVEIMRGLIRDSHILILDEPTASLTPAETHRLFSQIRMLLQQGVGVVFISHKLPEIRQLADWVSVMRDGGIALSGATADFSTEDMIQAMTPEAQKGALTDSQKLWLELPGNRRAQSHAQSQQPVIHVHDLSGEGFAHISFHVQAGEILGLAGVVGAGRTELAETLYGLRPASTGNVILEEVNITAMKTANRLAAGLVYLPEDRQASGLYLDAPLSWNVCALAHDRQGLWTQPAQEAAVLERYRRALNIKFSHLEQPVRTLSGGNQQKLLIAKCLEANPLLLIIDEPTRGVDVSARSDIYQLIRSIAEQQVAIIFISSDLEEVVQMADRVLVMHQGEINGALSGAAMNVDTIMHMAFGEHRSASEPQGGTASSAENKGASC
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Autoinducer 2 import ATP-binding protein LsrA, AI-2 import ATP-binding protein LsrA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AROE_STRPS
Sequence: MKLDGYTRLAAVVANPIKHSISPFIHNRAFEATATNGAYVAWEIEASDLAETVANIRRYQMFGINLSMPYKEQVIPYLDELSDEARLIGAVNTVVNENGNLIGYNTDGKGFFKCLPSFTISGKKMTLLGAGGAAKSILAQAILDGVSQISVFVRSVSMEKTRPYLDKLQEQTGFKVDLCALEYVSELQARIAESDLLVNATSVGMDGQSSPVPENIVLPETLLVADIIYQPFETPFLKWARSQGNPAVNGLGMLLYQAAEAFQLWTGKEMPTEEIWQSLTEKYQ
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: FTSH_SULNB
Sequence: MANPNNNNDNKQNNNNNFFNDNPLLAFAIFSIVIILIFKSFVGEGESLGTMMNTQGVAQTKQVKYSEIKKRIEEGAVKSVKLTPSMVEAIIEDNGRKVRYVAQNVPTYDRDLIPLLDKKKISYEGVVGNGFFSELISMMLPILIFFAIWIFLAKKMSKGMGGGILGAGKADKLINSEKPDTRFDDVQGVEEAKDEVKEIVDFLKFPERYIELGAKIPKGVLLVGPPGTGKTLLAKAVAGEASVPFFSVSGSGFIEMFVGVGASRVRDLFAQAKKEAPSIIFIDEIDAIGKSRASGGQMGGNDEREQTLNQLLAEMDGFGTDTPVIVLAATNRPETLDAALLRAGRFDRQVLVDKPDFEGRLAILKVHSKDVKLAPNVDLEIVAKQTAGLAGADLANIINEAALLAGRQNKKQIEQSDLLEAIERSFVGLEKKNRKINETEKKIVAYHESGHALMSELSEGATRVTKVSIIPRGLGALGYTLHLPEDEERFLKQKHELMAEVDVLLGGRAAEDVFIGEISTGAGNDLDRATAILKDMVSVYGMTDVAGLMVLSRSQNSFLGAGAVSTDYSDKTAEAMDSYIKSTLNERYGYVKETLQNYYGAIDNMAKELLGTEVIEGKTVRRIIEEYEQEKGMPSRLAHKDKVAKNKAEADKKEEALKKEISEESDNNKEA
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: SCX3_CENHU
Sequence: KEGYLVELGTGCKYECFKLGDNDYCLRECKARYGKGAGGYCYAFGCWCTQLYEQAVVWPLKNKTCR
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity).  Acts on human sodium channel Nav1. 6/SCN8A (Ref. 1).
What are the official names of this protein?
Beta-toxin Chui3, Chui3.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
Protein: LYT2_HOGCA
Sequence: KIKWFKTMKSIAKFIAKEQMKKHLGGE
What is the function of this protein?
Forms pore that permeabilize the cell membrane.  Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane.  Potently inhibits the growth of bacteria, yeast and Leishmania.  May function both in the prey capture strategy as well as protection from infectious organisms arising from prey ingestion (By similarity).
What are the official names of this protein?
M-lycotoxin-Hc2a, M-LCTX-Hc2a, Lycotoxin II, Lycotoxin-2.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 05 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NEP_I79A2
Sequence: MDSNTITSFQDILQRMSKMQLESSSADLNGMITQFERLKIYRDSLGESVMRMGDLHSLQNRNATWRDELSQKFEEIRWLIAECRNILTKTENSFEQITFLQALQLLLEVESEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: CRB3_RAT
Sequence: MSSCSRVALVTGANKGIGFAITRDLCRKFSGDVVLTARDEARGRAAVKQLQAEGLSPRFHQLDIDNPQSIRALRDFLRKEYGGLNVLVNNAGIAFRMDDPTPFDVQAEVTLKTNFFATRNVCTELLPIMKPHGRVVNVSSLQGLKALENCSEDLQERFRCDTLTEGDLVDLMKKFVEDTKNEVHEREGWPDSAYGVSKLGVTVLTRILARQLDEKRKADRILLNACCPGWVKTDMARDQGSRTVEEGAETPVYLALLPPDATEPHGQLVRDKVVQTW
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols.  Has low NADPH-dependent oxidoreductase activity (PubMed:18983987).  Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin.  Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones.  Exerts activity toward ortho-quinones but not paraquinones.  No endogenous substrate for CBR3 except isatin has been identified (By similarity).
What are the official names of this protein?
Carbonyl reductase [NADPH] 3, Monomeric carbonyl reductase 3, Quinone reductase CBR3.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUP8_ARATH
Sequence: MEITQVIYVNDHNNIEANLTGQEEMNTTMEIESSSVPQSKNYKKWLRISIYVFFVLACQALSTILGRVYYENGGKSTWMGTLVQLIGFPVLFLFRFFSQTKNPKPTEADFRKFSSFTILGSVYIVTGLLVSANSYMSSVGLLYLPVSTFSLILASQLAFTAFFSYFLNSQKFTPFIVNSLFLLTISSALLVVNTDSENTAKVSRVKYVIGIICTIGASAGIGLLLSLVQLILRKVLKKQTFSTVTDLVAYQSLVASCVVLIGLFASGEWKTLTSEMENYKLGKVPYVMTLASIAISWQVYTIGVVGLIFESSSVFSNSITAVGLPIVPVVAVIVFHDKMNASKIFSIILAIWGFISFVYQHYLDEKKLKTSHTSPVGDPHLLPAEEGHTNIHSV
What are the official names of this protein?
Probable purine permease 8, AtPUP8.
What is the protein family that this protein belongs to?
Belongs to the purine permeases (TC 2.A.7.14) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.