PharMolix/UniProtQA huggingface dataset:
Protein: GLSA_RHOP2
Sequence: MNPDLLDHTVAEIAAEMAQRPDRGAVASYIPELAGVDPQRFGLVVIDADGHVAAGGDADMPFSIQSISKVFTLTLALGLAGDRVWRRVGREPSGSAFNSIVQLERERGIPRNPFINAGAIAVTDLILSGHQPREALGEILRFMQFLAGDDSIVIDDAVAASEQRTGFRNAALANYMKSFGVLDNPVEYTLGVYFHHCAIAMSCRQLALAGRFLAHNGRNPSTGHNVVSTQRARRINALMLTCGHYDGSGEFAYRVGLPGKSGVGGGVLAVAPGKASIAVWSPGLDAAGNSHLGRIALEALTRRLGWSIFGV
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: RL2_THEVB
Sequence: MGIRVYRPYTPGVRQKTVSDFAEITTDKPEKSLTRGFKRDKGRNNRGVITSRRRGGGHKRRYRIVDFRRSSKLNIPAKVATVEYDPNRNARIALLHYRDGEKRYILHPRDLTPGTEIIASPDAPIEVGNALPLGKIPLGTSVHNVEITPGRGAQMVRAAGAMAQVVAKEGDMVTLKLPSGEVRLFRKECYATIGQVGNVEANNISLGKAGRNRWKGRRPKVRGSVMNPVDHPHGGGEGRAPIGRPGPVTPWGKPTLGYKTRKKKKLSDALIVRRRKKSSKRGRGGRQS
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: GCSPA_THIDA
Sequence: MPFIPHTEEDVSAMLGAIGAASIEDLFDEIPPALKTGKLKDVPDGLPEMAVARLMQERASQDGFWSNFIGAGVYEHHIPAAIWQITTRGEFYSAYTPYQAEASQGTLQLIYEYQTMMTRLTGLDVSNASLYDGASALAEAVLMAVRSHKSSRRVLVPKTVHPVYRSVVVTTVRNQGIDLVELEYDPATGKTVLPSEPGAFAGLVIPQPNFFGVLEDVHTMTDWTHANGGLAIALVNPTTLAVLEAPGKWGTKGADIAVGEGQPLGAPMASGGPYFGFMCCRQDFVRQMPGRIVGRTVDLDGKPGFALTLQAREQHIRRSKATSNICTNQGLVVTAATQYMALLGPQGLAKVAAASHANTVALAEKLGAIPGVARAFASPCFHEVVLKLDDGTLKGTSAKDVLRALRAQGILGGLDISGWYPELGQAILVCVTETKTGADLDHYAQHLERILSKRREAPPCAYKN
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: MNTH_SHIF8
Sequence: MTNYRVESSSGRAARKMRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLLLFVAAAYIVELIFSQPNLAQLGKGMVIPSLPTSEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGSRQQRYSATKWDVAIAMTIAGFVNLVMMATAAAAFHFSGHTGVADLDEAYLTLQPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFIRFHIPLWVRRTVTMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSDSKLMGDLVNSKRVKQTGWVIVVLVVALNIWLLVGTALGL
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL3_LACAC
Sequence: MTKGILGRKVGMTQIFTKDGILVPVTVVEATPNVVMQVKTVESDGYEAVQLGYQDKREVLSNKPEKGHADKAKTSPKRFIREIRGVELKDYEVGSEVTVDTFKEGDVVNVTGTSRGHGYQGNIKRWGQSRGPETHGSRYHRIPGSMGSIINRVPKGKRLPGHMGVKKVTIENLVIEKVVADKNVLMIKGNVPGAKNSLIVVKTASKAVKADK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ATP6_USTMA
Sequence: MAFLIHSPLEQFEVTSLISLNLPVLGYINLSLTNLGLYTILTVYLVLALHIMGSNNKQLIPSRWSIALESSFASVHGLVKSQIGAANEMYLPFIYSLFFFILIANLSGNVPYGFTVATSIMVSIGLSMTIFIGVTILGLRLHKVHFFSFFVPSGTPLGLVPLLVPIELISYLARAFSLGVRLFANVTAGHVLMKILAGFLAPLFTSTFIISVLTVLPFIIFTGIIGLEIAVSFIQAYVFCVLTCSYLKDAIDLH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TAT_SIVM1
Sequence: METPLREQENSLESSNERSSYISEAAAAIPESANLGEEILSQLYRPLEACYNTCYCKKCCYHCQFCFLKKGLGISYEKSHRRRRTPKKAKANTSSASNEPIPNRIRLCQPKKAKKETVEAAVATAPGLGR
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors.  Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.  Through (By similarity).
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus.
Protein: PA2BA_CRODR
Sequence: HLLQFNKMIKFETRKNAIPFYAFYGCYCGWGGRGRPKDATDRCCFVHDCCYGKLAKCNTKWDIYPYSLKSGYITCGKGTWCEEQICECDRVAAECLRRSLSTYKYGYMFYPDSRCRGPSETC
What is the function of this protein?
Snake venom phospholipase A that has strong antimicrobial activity against the Gram-negative bacterium X. axonopodis.  Antimicrobial activity is not abolished by EDTA or p-BPB and is therefore not strongly dependent on the enzymatic activity.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 A, svPLA2, Crotoxin basic chain 1, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DNBI_ELHVK
Sequence: MSSDDNNIASSASSGHGAWIYITEKTPDVLDILNRLVLTSADSDVTIAPLLYDVTVEPGFELTVKCPLMLTDNNVILKLSNFMPCVFIINSTSSEDFRFCEDVVGNVSEICEGAASRYGYTADFTEFNERTETTDSDVCSNVNVPESDYFVYIACTYGYKELLFKGYLIPHWQDLRDISIGNRRGYKIPLLSPFLFTQCKDDTVQLTDQFILDNGFYNPDLTKTLYSYIFRPLAVSLRYLDVTHLISVTLNQYITDTHATAKLCDKKVYTCHGNNKLSTGDRDVLALCDILANEVTVSYLTPFLDSAYDAPSTLDFYSWPIVKDKTHAEILENLDQFLLHMSVHIGTLIFSGNSVLYQNKISKVGGQSDGSNGQSVEGLLKSIYHTTGIQLLYEDGYDDTRSLVRQHTAKPKNLKFNMDHLSFGASFSSHVLTKIVWFLNRSEEYKTTQSVSSTCYLVINSSTGTCTACDGKHCNTCIGALMCRMATRFPNINRQQKKEPCVTTLLTRMFADMTILGSFGKKYNTERDTQQKDGRVSAEPLDKAKYVLNILDYCKRECLIDSDGNDTLKISSKQEFIKIITGLNRTIDDELIKLLSDMRKHSNAKDDLNNSTMSFTLDLNPHAYAFSPLLQFVYMKTLVNILESLAIVVIAEKISSYPMTQSAYSRWVKQHFQSVYSEFKKSIYKKGFLTLSDYKMKNTTTNDTFTDFSHLKRDYKIDNTVRSSIATVNYQCRLWNFHVSSLRDFRIKYKPIPKNKDSPYFQKADKGIQNPVCGPLSFLITRFHKDIFPNVNVSPMTLWQRIYSNTLKNFNVDLGDKHDVETFIKFMFEQTVEYEGSNSIDVRPETILQYIEFRFVNRLLHASGHRGQYIGIVQALCTTLSDTKVDGLPCYLDSSRTFGTVSEYHAYCREYNGTVKVGRTRPYCNTNGMFERRPLVTVPYALEKYTGAAGNASIFQCGQLGYFSGTGIDRNLGMINRTSDYNFMRRKHIFCTPLTDVLFTKISRGAHVFDFDMLKQRIKQLLDEHCGGFDIELAILSEILKHVKEPNYNDLLFITGYQEHIASSLFDKIKVLDELEISSYSIESLQEIFPEKEELNDTEATGSGYDFSFIIPKATDVDEITGLNIQEFTNIEDETPLVKRMRL
What is the function of this protein?
Plays several crucial roles in viral infection.  Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein.  May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.  Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle.  Can also catalyze the renaturation of complementary single strands.  Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments.  This process is driven by the protein which can form double-helical filaments in the absence of DNA.
What are the official names of this protein?
Major DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae major DNA-binding protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=In the absence of DNA replication, found in the nuclear framework- associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).
Protein: RT10_KLULA
Sequence: MNMFRQAVRSFVRYQSTTSLNPKILPFNAKETPIPKCVEAVYHAPLKIEPTHRDLIADIQLRSYDNENLDFFSSFVLRAGYYLGIPMKGPKPLPTKRKRWTVIRAPFVMAKSKENFERHTHARLIRLYDCNTELVETLLSYISKHGISGVGIKCNLYQREPIDLDSKKDGPELENIDISSQLQGLDDVVGAKVVELLNNPEFKKHLQ
What is the function of this protein?
Involved in mitochondrial genome encoded proteins translation.  Involved in the binding of tRNA to the ribosomes (By similarity).
What are the official names of this protein?
37S ribosomal protein S10, mitochondrial, Mitochondrial ribosomal small subunit protein 10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: 5DNU_ECO57
Sequence: MKQSHFFAHLSRLKLINRWPLMRNVRTENVSEHSLQVAMVAHALAAIKNRKFGGNVNAERIALLAMYHDASEVLTGDLPTPVKYFNSQIAQEYKAIEKIAQQKLVDMVPEELRDIFAPLIDEHAYSDEEKSLVKQADALCAYLKCLEELAAGNNEFLLAKTRLEATLEARRSQEMDYFMEVFVPSFHLSLDEISQDSPL
What is the function of this protein?
Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
What are the official names of this protein?
5'-deoxynucleotidase YfbR, 5'-deoxyribonucleotidase, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the 5DNU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_EXIS2
Sequence: MKQGIHPNYNKVVFMDSTTEYKFLTGSTRSSNETITWEDGNEYPLIRVDVSSDSHPFYTGRQKFNAADGRVDRFNKKYGRK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: RIHB_SHIDS
Sequence: MAALPINGLNVCQKLEINVPVYAGMPQPIMRQQIVADNIHGETGLDGPVFEPLTRQAESTHAVKYIIDTLMASDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGNFTPSAEFNIFADPEAARVVFTSGVPLVMMGLDLTNQTVCTPDVIARMERAGGPAGELFSDIMNFTLKTQFENYGLAGGPVHDATCIGYLINPDGIKTQDMYVEVDVNSGPCYGRTVCDELGVLGKPANTKVGITIDTDWFWGLVEECVRGYIKTH
What are the official names of this protein?
Putative pyrimidine-specific ribonucleoside hydrolase RihB, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihB subfamily.
Protein: RS3_FUSNN
Sequence: MGQKVDPRGLRLGITRAWDSNWYADKKEYVKYFHEDVQIKEFIKKNYFHTGISKVRIERTSPSQVVVHIHTGKAGLIIGRKGAEIDALRAKLEKLTGKKVTVKVQEIKDLNGDAVLVAESIAAQIEKRIAYKKAMTQAISRSMKSPEVKGIKVMISGRLNGAEIARSEWAVEGKVPLHTLRADIDYAVATAHTTYGALGIKVWIFHGEVLPSKKEGGEA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PYRE_CLOBH
Sequence: MSNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVDFNIIVGPAMGGVIVSYELARQTNKPGIFAERKEGVMCIRRGFEIKKGDKVIISEDVVTTGKSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSACKLEIETYEKDNCELCKKNIPFVKPGSREQK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: RS16_PARDP
Sequence: MAMKIRLARGGSKKRPHYAIVASDSRMPRDGRFIEKLGTYNPLLPKDSEDRIKMNLERVQYWLGQGAQPTDRVARFLEAAGVKEKAERKNLKKGEPGKAAKERAEKRAAREAAANAPAEEAASE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: YBGB_BACSU
Sequence: MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDLTVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL
What are the official names of this protein?
Uncharacterized membrane protein YbgB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCH1L_BORBU
Sequence: MNVRDLSFKLNSIFDINKYEHIDKNLNGLQVGNINAKVNKVAFAVDASFSTLKEAKGNDFLITHHGIFWSKKERIVSNMYDKTKFLIENNLALYSVHLPMDAHSVYSHSKVFSDFLGLKNSFAFANYGGVNLGIIADSVFSFSEILEKIKKENKHILFSKKFKESVNKVAIVSGSGYSFFEEALCHDVDLFITGDTSHQIYSLAEEFGVNLIFAGHYFTETFGLIKLMEDFKIQEDLEVKFICKNTNL
What are the official names of this protein?
GTP cyclohydrolase 1 type 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
Protein: NUOH_BUCAP
Sequence: MNSLGINIYEILFQILHITLIIIFIIFFAATLSILERKFLAFFQNRHGPNRVGWFGSLQLCADMIKILFKEDWVPQFSKKSIFILSPIIAFVSLLLVIPTIPFTPNFLIINLNIGILFFLMMASLSVYAVLFAGWSSNNKYSLLGAIRASAQTLSYEVFLGLSLMGVIARSGSFNIVDIVNSQKEVWNVIPQFFGFLCFFIAGIALCHRHPFDQPESEQELADGYHIEYSGMKFGLFFIGEYISIITVSALISTVFFGGYFGFWGSSFFWLFLKTVFFILIFILIRASLPRPKYDQIMSFGWKICLPLTLLNLIITAFFILI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LRAT_MOUSE
Sequence: MKNPMLEAASLLLEKLLLISNFKLFSVSVPGGGTGKNRPYEISSFVRGDVLEVSRTHFIHYGIYLGENRVAHLMPDILLALTNDKERTQKVVSNKRLLLGVICKVASIRVDTVEDFAYGADILVNHLDGTLKKKSLLNEEVARRAEQQLGLTPYSLLWNNCEHFVTYCRYGSRISPQAEKFYDTVKIIIRDQRSSLASAVLGLASIVYTGLASYMTLPAICIPFCLWMMSG
What is the function of this protein?
Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters.  Retinyl esters are storage forms of vitamin A (PubMed:28758396).  LRAT plays a critical role in vision (By similarity).  It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (By similarity).  Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (PubMed:25416279).
What are the official names of this protein?
Lecithin retinol acyltransferase, Phosphatidylcholine--retinol O-acyltransferase, Phosphatidylcholine-retinol-O-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the H-rev107 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Rough endoplasmic reticulum. Endosome, multivesicular body. Cytoplasm, perinuclear region. Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity).
Protein: RF1_STRGG
Sequence: MFEAVEELIGEHTGLEKKLADPSVHADQANARKLNKRYAELTPIVSTYRAWKQTGEDIETAREFAADDPDFAAEVKELEKQREEITEKLRLLLVPRDPSDDKDVLLEIKAGAGGDESALFAGDLLRMYLRYAERVGWKTEIIDSTESELGGYKDVQVAVKTKGGNGATEPGQGVWARMKYEGGVHRVQRVPSTESQGRIHTSAAGVLVTPEAEEVDVEIHANDLRIDVYRSSGPGGQSVNTTDSAVRITHLPTGVVASCQNEKSQLQNKEQAMRILRSRLLAAAQEAAEQEASDVRRSQVRTVDRSEKIRTYNFPENRISDHRVGFKAYNLDQVLDGELDAVIQACVDADSAAKLANA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEDA_ECO24
Sequence: MKKPLRQQNRQIISYVPRTEPAPPEHAIKMDSFRDVWMLRGKYVAFVLMGESFLRSPAFTVPESAQRWANQIRQEGEVTE
What is the function of this protein?
Activates the cell division inhibited by chromosomal DNA over-replication.
What are the official names of this protein?
Cell division activator CedA.
What is the protein family that this protein belongs to?
Belongs to the CedA family.
Protein: CH60_BACMK
Sequence: MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVTAAIEELKAISKPIEGKSSIAQVAAISSADEEVGQLIAEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQQGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVITEELGRDLKSATVESLGRAGKIVVTKENTTVVEGIGNSQQIEARIGQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTSLMNVYTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATGEWVNMLESGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TVAM2_HUMAN
Sequence: MAGIRALFMYLWLQLDWVSRGESVGLHLPTLSVQEGDNSIINCAYSNSASDYFIWYKQESGKGPQFIIDIRSNMDKRQGQRVTVLLNKTVKHLSLQIAATQPGDSAVYFCAEN
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 13-2.
What are the subcellular locations of this protein?
Cell membrane.
Protein: GPDA_SALDC
Sequence: MNQSNASMTVIGAGSYGTALAITLARNGHQVVLWGHDPKHIATLEHDRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFSDVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDETFADDLQQLLHCGKSFRVYINADFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLTEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVKGAQDKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKEELSRH
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRF_YERPS
Sequence: MEIILGVVMFTLIVLALTVMILFAKSKLVNTGDITVEINEDEDKSFTAPAGDKLLNMLSSHGIFVSSACGGGGSCGQCRVTIKEGGGDILPTELSHISKREAKEGCRLACQVNVKQNLKIELPEEIFGVKKWTCEVISNDNKATFIKELKLKIPDGDVVPFRAGGFIQIEAEPHTVKYADFDVPTEYRGDWDKFNLFRFESVATEPTVRAYSMANYPEEHGIILLNVRIATPPPSVPDAPPGIMSSYIWSLKPGDKVVISGPFGEFFAKDTDAEMVFIGGGAGMAPMRSHIFDQLKRLHSKRKISFWYGARSRREMFYEEDFDQLQAENDNFRWHVALSDPQPEDNWTGYTGFIHNVLLENYLKDHPAPEDCEFYMCGPPMMNAAVIKMLKDLGVEDENIMLDDFGG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit F, Na(+)-NQR subunit F, Na(+)-translocating NQR subunit F, NQR complex subunit F, NQR-1 subunit F.
What is the protein family that this protein belongs to?
Belongs to the NqrF family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ADXH1_DROME
Sequence: MFCLLLRRSAVHNSCKLISKQIAKPAFYTPHNALHTTIPRRHGEFEWQDPKSTDEIVNITYVDKDGKRTKVQGKVGDNVLYLAHRHGIEMEGACEASLACTTCHVYVQHDYLQKLKEAEEQEDDLLDMAPFLRENSRLGCQILLDKSMEGMELELPKATRNFYVDGHKPKPH
What is the function of this protein?
Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition.
What are the official names of this protein?
Adrenodoxin-like protein 1, mitochondrial, Ferredoxin-1.
What is the protein family that this protein belongs to?
Belongs to the adrenodoxin/putidaredoxin family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: NS7B_CVCAK
Sequence: MKFLIFVLCLSLVNGYGIRRSIQEYDPKESHEHPTMTWELLEKFVGSTLYITTNQILSLPLGAEIYCDEIEGFPCSWPGYKAYAYNHIDYHFDLSSPFYSFVDKFYISLGDREEKIHLRVVGATPKDKRLTVGCRTSFSVNLPIGTQIYHDKDMQHLVEGRHLECAHRVYFVKYCPSHSHGYCFKDKLKVYDLKRVKSRKCFEKINQQQKSEL
What are the official names of this protein?
Non-structural protein 7b, ns7b, Accessory protein 7b.
Protein: PHS_MYCBO
Sequence: MAVLTDEQVDAALHDLNGWQRAGGVLRRSIKFPTFMAGIDAVRRVAERAEEVNHHPDIDIRWRTVTFALVTHAVGGITENDIAMAHDIDAMFGA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.