PharMolix/UniProtQA huggingface dataset:
Protein: TRET1_DROMO
Sequence: MSGRDNRGAGGGGGGGHHHQPLSSAMGKLKEKLTRAGEELGYHRVESNLSASNTGTSLDTILPEDPFPFPQAAPQRHPQQQFPHLHPLRLLHDVDDEPPLSFRPLLEDDDINEPPQQIQQQRSALRSSGSLELTPLPPPPTSLEPHRDRQQRSIVTGGEELQRSKQSLKGSRVSFEKPQQQGNNKAAESSDEDSFEDKRIGFQQQKATSVDHKGILKDLRHILANDNRRQFQAKKHVSLDIKGTRFLQDLLKDSSSEEEFHKTRREFQGRKHQSLDPRVTFKLDKVLQGSSTDSDEEGDDAEHKRLIHRPKDITKPVIIDLKDLESESDEDFLTSRQNFQQQRSISTDSRKSRRLYEMDEMGNKRGDNIRHAVPFVRQITEDGKPKLEVYRPTTNPIYIWTQVLAALSVSLGSLVVGFASAYTSPALVSMTNTNLTSFVVTPQAASWVGGIMPLAGLAGGIAGGPFIEYLGRRNTILATAVPFIISWLLIACAVNVVMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAGTYMDWSMLAFLGGTLPVPFLILMFLIPETPRWYVSRGREERARKALVWLRGKEADVEPELKGLMRSQADADRQATQNTMLELLKRSNLKPLSISLGLMFFQQLSGINAVIFYTVQIFQDAGSTIDGNVCTIIVGVVNFMATFIATVLIDRAGRKILLYVSNVAMILTLFVLGGFFYCKSTGMDTSNVGWLPLSCFVVYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWSCTFVVTKSFQDMIDVMGAHGAFWMFGAICFVGLFFVIFYVPETQGKTLEDIERKMMGRVRRMSSVANIKPLSFNM
What is the function of this protein?
Low-capacity facilitative transporter for trehalose.  Does not transport maltose, sucrose or lactose.  Mediates the bidirectional transfer of trehalose.  Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (By similarity).
What are the official names of this protein?
Facilitated trehalose transporter Tret1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: XYL1_ARTOC
Sequence: MASTTPNLTAPAVKLNSGYAMPIVGFGLWKVNKETCADQVYNAIRTGYRLFDGACDYGNEVEAGKGVARAIKEGIVRREDLFIVSKLWGTFHDPEHVEPACRRQLSHWGIDYFDLFIVHFPISLKYVDPEVRYPPEWSAPGEKAESGNVPLYKTWGAMEELVDKRLARSIGISNFSPQLIMDLLRYARIRPSTLQIEHHPYLTQEGLIKYAQDEGLVVTAYSSLGPQSFIELENKAATGTTLLLEHPTIKSSAEKHGKTPAQILLRWATQRGIAVIPKSNNPDRLAQNLDATGFNLTANELRAISALDQGLRFNNPPSYGVNFPIFG
What is the function of this protein?
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol.  Xylose is a major component of hemicelluloses such as xylan.  Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).
What are the official names of this protein?
Probable NAD(P)H-dependent D-xylose reductase xyl1, XR.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: RR7_SPAWA
Sequence: MSRRGTAEKKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIRGVTPDIAVKARRVGGSTHQVPIEIGSTQGKALAIRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHKMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GPMA_BRUSU
Sequence: MSRTLVLVRHGQSEWNLKNLFTGWRDPGLTEQGHAEAKAAGQRLKAAGLKFDIAYTSALSRAQVTCQHILDELGQPGLETIRDQALNERDYGDLSGLNKDDARAKWGEEQVHIWRRSYDVPPPGGESLKDTGARVWPYYLHTIQPHVLREETVLVAAHGNSLRALIMALDGLTPEQILKQELNTGVPIIYRLNADSTVASKEILSA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: SYUG_MOUSE
Sequence: MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGTKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVANKTVEEAENIVVTTGVVRKEDLEPPAQDQEAKEQEENEEAKSGED
What is the function of this protein?
Plays a role in neurofilament network integrity.  May be involved in modulating axonal architecture during development and in the adult.  In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases.  May also function in modulating the keratin network in skin.  Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
What are the official names of this protein?
Gamma-synuclein, Persyn.
What is the protein family that this protein belongs to?
Belongs to the synuclein family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle (By similarity).
Protein: LEPA_LACLM
Sequence: MNLQEMNARKEKIRNFSIIAHIDHGKSTLADRILEQTETVSKREMQAQLLDSMDLERERGITIKLNAIELNYKAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPEMVRQEIEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPQGEVDAPLKALIFDSVYDAYRGVILQIRVIDGSVKVGDRIQLMSNGKEFDVTEVGIFTPKAVSRDFLMAGDVGYVAAAIKTVADTRVGDTVTLASNPATEALEGYKEMNPMVFAGIYPIESNKFNDLREALEKLQLNDASLRFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFGIDLIMTAPSVVYHINTTDGETLEVANPSEFPDPTRIENIEEPFVKAQIMVPNDFVGPVMELAQRKRGIFLTMDYLDANRVNIIYHIPLSEIVFDFFDKLKSSTKGYASFDYEISDYRPSNLVKMDILLNAEKVDALSFIVHKDFAFERGKVIVEKLKKLIPRQQFEVPIQATIGNKIVARSDIKALRKNVLAKCYGGDISRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDEE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS11_ALKMQ
Sequence: MAKVVRKKTVRRKKDRKNIERGQAHIQSTFNNSIVTLTDMQGNTIGWSCAGQLGFKGSRKSTPFAAQMCAEAAAKSAMEHGLKTIEVFVKGPGAGREAAIRALQAAGLEVSLIKDVTPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: PYREL_HALWD
Sequence: MKNVDDLIENAAELAERGLSKGEIADELNVSRETASWLVERSQPTDNSQSSSANNPTEAHDIHVDWSAVGRDSKRLTYIGQAMADLLMKEGEAVDLTIGIEKAGASLSTVVAQELDTDLGSYAPAKHQWDEGDIDELGGSFSRNFAQIRDRDCYIVDDTITSGTTMQETIDAIRDAGGRPVACVVVVDKQGVDSLADVPVYSLIDVVRVDSDTNDRDISNK
What are the official names of this protein?
PyrE-like protein.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: PP14D_RAT
Sequence: MLSSSAASCTSPNPDTDNPDKKVRWSSEKRRRASSTDSESKTHLDISKLPRSRRPSRLTVKYDRGHLQRWLEMEQWVDAQVQELFQGQADTSEPEIDLEALMELSTDEQRTQLEAILQDCPGNREPFISELLSQLKRLRRLSRPSK
What is the function of this protein?
Inhibitor of PPP1CA.  Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity).
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 14D, Gastrointestinal and brain-specific PP1-inhibitory protein 1, GBPI-1.
What is the protein family that this protein belongs to?
Belongs to the PP1 inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRG1_TAKRU
Sequence: MAEYTKVKSTKLVLKGQKQGKKHKHKDRKRKATDEDEKPDIVGGWWVVKSFVEMNGTVALEMQNNAYIHALDSGLFTLGAPHKDDEGPDPPEQFTTIKLSDSRIALKSGYGRYLGINSEGLVVGRSDAIGPREQWEPVFQDGKMALLAANSCFISYSDSGDIVANSKTAGDEEMLKIRTSAERETRSKDDLAEEDRGNVKSCEVNYVKKFQSFQDRRLRVNEGDSMTLKKARTDGKFHEALLDRRSKMKADRYCK
What is the function of this protein?
Binds to mRNA in a sequence-independent manner.  May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits.  May be involved in mRNA transport.  May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B.
What are the official names of this protein?
Protein FRG1.
What is the protein family that this protein belongs to?
Belongs to the FRG1 family.
What are the subcellular locations of this protein?
Nucleus, Cajal body. Nucleus, nucleolus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line.
Protein: GLMM_XYLFA
Sequence: MRVSRYFGTDGIRGRVGQGLISADFVLRLGNALGRVLAQGRDTRPMVLIGKDTRISGYMFESALEAGLVAAGADVQLIGPMPTPAIAFLTNTLRADAGVVISASHNPHDDNGIKFFSAMGEKLDDATEAAIEAAIEAPFLTVDSEYLGKVKRTRDAIGRYIEFSKASVPRGFTLRGLKLVLDCAHGATYHIAPMLFRELGAELVAIGVDPDGLNINAGVGSTHLETLAATVRESGADLGIAFDGDGDRVLMTDAQGRTVDGDDLLYVLARAWRASGRLKGTVVGTLMSNYGLEQALGTLGIPFIRAKVGDRYVHQALVESGGVLGGEASGHLLCLDRATTGDGIVSALQVLEVLRHEGLTLSQALLGLHKVPQKTVNVCWSGPARAAVEMPEVRQALVEAQAAVQGRGRVFLRPSGTEPVVRITVEADDVVLMQQTLDRLADVVRDAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: UNG_HAEIE
Sequence: MKNWTDVIGKEKEQPYFQHALQQVHLARANGKTIYPPQEEVFNAFKYTAFEDVKVVILGQDPYHGANQAHGLAFSVKPEVAIPPSLLNMYKELTQDISGFQMPSNGYLVKWAEQGVLLLNTVLTVERGMAHSHANLGWERFTDKVIAVLNEHREKLVFLLWGSHAQKKDKLIDRTRHLVLTAPHPSPLSAHRGFFGCHHFSKTNSYLESNGMKPIDWQI
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTBC1_METAC
Sequence: MSKEELLQELAGAVITCKKDAVLAAVEKAKGELDPSEIIEKGLAAGMNEVGVLFERGKLFLPHVMMAADAMTAGVEALKDLMPEGSASSKMGVIVNGTVEGDVHDIGKSIVSTMLQSAGFEVHDIGRDVPIKNFVEKAKEVNADMIGLSALMTTTLPGQRDVIELLKEEGLRENVKVMIGGAPATQAWADKIGADCYAENASEAVAKAKELLA
What is the function of this protein?
Acts as a methyl group carrier between MtbB and MtbA.
What are the official names of this protein?
Dimethylamine corrinoid protein 1.
What is the protein family that this protein belongs to?
Belongs to the methylamine corrinoid protein family.
Protein: LLDD_PSEAB
Sequence: MIISASTDYRAAAQRKLPPFLFHYIDGGAYAEYTLRRNVEDLSAIALRQRVLKNMSELSLETRLFDETLAMPVALAPVGLTGMYARRGEVQAARAAAAKGVPFTLSTVSVCPIEEVAPAIDRPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPVPGARYRDAHSGMSGPYAAPRRILQAMTHPAWAWDVGLLGKPHDLGNISAYRGNPTGLEDYIGWLGANFDPSIAWKDLEWIREFWDGPMVIKGILDPEDARDAVKFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELAILADSGIRTGLDVVRMIALGADSVLLGRAFVYALAAAGEAGVRNLLELIEKEMRVAMVLTGAKSIGEISADSLVRELGA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: IF5A_PYRNV
Sequence: MSTKYVEAGELKEGSYVVIDGEPCRVVEIEKSKTGKHGSAKARIVAVGVFDGGKRTLSLPVDAQVEVPIIEKFTAQVLSISGDIIQLMDMRDYKTIEVPMSYVEEEAKGRLAPGAEVEVWQILDRFKIVRVK
What is the function of this protein?
Functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Translation initiation factor 5A, Hypusine-containing protein, eIF-5A.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAZ_MACMU
Sequence: MPLHVKWPFPAVPPLTWTLASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPILERLRAENKSAVEMRKALTDFIQEEFQRLKTQAEQLHNHLQPGR
What is the function of this protein?
Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity).  Its role in cellular physiology is to improve mitochondrial performance (By similarity).  RCL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity).  Catalyzes the transacylacion between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL.  Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations.  Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate.  Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution.  Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor.  CoA-independent, it can reshuffle molecular species within a single phospholipid class.  Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL.  Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane.  Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes.  Essential for the final stage of spermatogenesis, spermatid individualization (By similarity).  Required for the initiation of mitophagy (By similarity).  Required to ensure progression of spermatocytes through meiosis (By similarity).
What are the official names of this protein?
Tafazzin, Taz.
What is the protein family that this protein belongs to?
Belongs to the taffazin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: Y1193_KINRD
Sequence: MSFSPRGPSRPVLRRRRRGAALPTVVILVAVVIAVVVGARITADVWWFDQLGFLPTFTTKLWLQVLLFTLGALLLAAAVAVSLTLGYRARPIYAPVSDEQAGLDRYRESLEPLRRLVVVVLSAAAGLFGGSVAMSRWETLLLWWNRVDFGTRDEQFRMDQGFYVFTLPWLAFLVSFLTAAVVLAGIAGLAAHYLYGGLRLSGAGPRTTRAARVHLASLAAAFLLLRAAGYWLDRYELMTTSSGYVRGVVGPTYTDVHAVLPSKAILALIAVVVALLFVAAAVGTSWRLPAIGTGLLVVSAIAIGGIYPWAVQRFQVTPNRQSLESEYVGKNIDATRDAYDLSDVEVSTYAADTTASQGQLSEDAQTIPSVRLLDPSVVSQAFQQTQGQRGYYKFGETLDVDRYATPDGGTQDAVVAARELNLAGLADNQRTWVNEHTIYTHGYGVVVAQGNDRAPDGSPSYVEANVPTSGDLDLEQPRIYFGEGTTTYSIVGGRDNEIDYPDGSAGGFATTEYDGSGGVAVGSLLQKLVYGLKFGDQNILLSGSVTPESRILYDRTPRERVEKVAPWLTMDGDAYPSIVDGRVVWILDGYTTSNSYPYSAATELGDATTDALTQTQGSSVQALQDRTVNYVRNSVKATVDAYTGKVDLYAWDDTDPVLKAWMKAFPGAVEPLSAIDGSLMQHLRYPQDMFKVQREVLTRYHVTDPASFLTGQDFWDVPGDPTVDAAAGTVRPSQPPYYLTLRMPEQDTPTYSLTTTYVPASNANASGTQVLRGFAAVDSDAGSTKGTKSEGYGTIRLLELPQSTTVNGPVQIQNNIRSDTAVADQVRLLSVGDNSRVIYGNLLTLPVGGGLLYVEPIYAQSTGDNSFPRLSRVVAVFGDNIAIANTLDEALDEVFGGNSGAGAGDEGAPPPTAGTPAPTDGATGGPAPDPATGDAQVQLQQALDNAKRAIQDSSAALAEGDFTKYGEAQQRLRAAVDAASAAEARLERSGTSGPTSSSSPSASSAPPVPGETPAATPTP
What are the official names of this protein?
UPF0182 protein Krad_1193.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HMX1_YEAST
Sequence: MEDSSNTIIPSPTDVGALANRINFQTRDAHNKINTFMGIKMAIAMRHGFIYRQGILAYYYVFDAIEQEIDRLLNDPVTEEELQTSTILKQFWLEDFRRSTQIYKDLKLLYSNTFKSTESLNEFLATFQKPPLLQQFINNIHENIHKEPCTILSYCHVLYLALFAGGKLIRSNLYRRLGLFPNFEKLSQKELVKKGTNFFTFSDLGPTEETRLKWEYKKNYELATRTELTEAQKLQIISVAEGIFDWNFNIVAEIGELNRRELMGKFSFKCITYLYEEWMFNKDSATRRALHTVMLLVLSIIAIWVLYFLVKSFLSIV
What is the function of this protein?
Plays an important role in the degradation of heme under conditions of iron deprivation.
What are the official names of this protein?
Heme-binding protein HMX1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Protein: TRMFO_STACT
Sequence: MAETVVNVVGAGLAGSEAAYQLAQRGIKVNLIEMRPVRQTPAHHTDKFAELVCSNSLRGNSLTNAVGVLKEEMRRLDSLIIKAADAARVPAGGALAVDRHDFAGYITDTLKSHPNVNVINEEIESIPEGYTIIATGPLTTEGLAKEIVEITGEDQLYFYDAAAPIIEKESIDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFYDAVLEAEAAPVNEFEKEKYFEGCMPFEVMAERGRKTLLFGPMKPVGLEDPKTGKRPFAVVQLRQDDAAGTLYNIVGFQTHLKWGAQKEVIRLIPGLENVDIVRYGVMHRNTFINSPDVLSETYQLKGNDHLYFAGQMTGVEGYVESAASGLVAGINVAHKLQDKAEVVFPRETMIGSMAYYISHANNNKNFQPMNANFGLVPSLEKRIKDKKERYEQQANRALTYLENFKQTL
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIOX1_MOUSE
Sequence: MDELPNGNGAALLKRGRGRRRRHPQSQPRGASVLALPLRPRKIRRHRKSAAASRVAALRARALRSEDSDSKVAVASVRGKRKRPAELLEASRSAEPRPVSARPRSASATLPSRVEGWAALSRNLGTAAPPPPGSHADEPGRPRASPLQQVLTELNGIPSSRRRAARLFEWLLAPLPPDHFYRRLWEREAVLVRRQDRSYYEGLFSTADLDSMLRYEDVQFGQHLDAARYVDGRRETLNPPGRALPAAAWSLYRAGCSLRLLCPQAFSPTVWQFLAVLQEQFGSMAGSNVYLTPPDSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRDPSEELALTSSPNFSQEDLGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDFLEAVLPLAVQAAIEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKVRVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVHGLPVRWEAGEPVNVGAQLTTETQVHMLQDGVARLVGEGGRLFLYHTVENSRVYHLEEPKCLEIHPQQADAMELLLRSYPEFVRVGDLPCDSVEDQLSLATMLYDKGLLLTKTPLVPS
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:19927124).  Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (PubMed:19927124).  Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (PubMed:19927124).  Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (PubMed:19927124).  Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (PubMed:35210392).  Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity).  Participates in MYC-induced transcriptional activation (By similarity).
What are the official names of this protein?
Ribosomal oxygenase 1, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66.
What is the protein family that this protein belongs to?
Belongs to the ROX family. NO66 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: YGNB_SCHPO
Sequence: MSKGPGDFKKSWNGFAAQTPQNTPSSDVHLSKAALEKARQTLQSQLEDKSAHDEVSGLLRNNPAMLSMIEGRLSSLVGKSSGYIESLAPAVQNRITALKGLQKDCDAIQYEFRQKMLDLETKYEKKYQPIFSRRAEIIKGVSEPVDDELDHEEEIFQNNLPDPKGIPEFWLTCLHNVFLVGEMITPEDENVLRSLSDIRFTNLSGDVHGYKLEFEFDSNDYFTNKILTKTYYYKDDLSPSGEFLYDHAEGDKINWIKPEKNLTVRVETKKQRNRKTNQTRLVRTTVPNDSFFNFFSPPQLDDDESDDGLDDKTELLELDYQLGEVFKDQIIPLAIDCFLEEGDLSDFNQMDEEDSEDAYTDEEDLSSDDEEILSSEISD
What are the official names of this protein?
Putative nucleosome assembly protein C2D10.11C.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AT134_CHICK
Sequence: MGENPAKSHYAQLNLGEENEMEIFGYKTQCCRKALCIAGYILSCGALLLLFYWKPEWDVWANCVPCSLEEADVVLLRTTDEFRIYSRKNVTWISVSGIIKSRLDYPSFAEEDSIFSKALMKPSLQVKSIQVQKIRYVWNIYAKQFQKVGALEDHHTCSAIHTKFGSGLTCSEQSLRRVICGPNTIDVPVIPIWKLLIKEVLNPFYVFQLFSVCLWFAEDYMEYAAAIIIMSPLSISLTVYDLRQQSVKLQRLVESHNSIMVTGRNKEGFQELESHHLVPGDMVVLKEGKALLPCDAILISGQCIVNESMLTGESIPVTKTQLPQADNLKPWKMHCAEDYKKHVLFCGTEVIQTKGDDRGVVKAVVLQTGFNTAKGDLVRSILYPKPMNFRLYRDALRFLMCLIAFAAIGMIYTVCVFALNGEEAGEVVKKALDVITIAVPPALPAALTTGIIYTQRRLKKKGIFCISPQRINMCGQLNLICFDKTGTLTEDGLDLWGLLPSEGNCFQDVRRFPADHSLPWGPAFRAMVVCHSLIVLEGKIQGDPLDVKMFEATNWVIDDSSGHQIEGQRSTHATVIRPGPKANTASVDGITILHQFPFSSALQRMSVIAQETGGEKQAFTKGAPEMVATLCRAETVPSNFESKLLFYTAQGFRVIGLAYKSLQSGKQSTDLTREEVESDLTFLGLLIMENRLKRETKPVLEELSAAHIRSVMVTGDNIQTAVTVAKNAGMISPTNRVILVEANKIPGSFSASVTWKPLKENKTEDDGNLDSGSQTGRRIRLAAEPGQFHFAMSGKSYQVVAQYFSHLLPKLLLNATVFARMSPSQKSSLVEEFQKLDYFVGMCGDGANDCGALKVAHAGISLSEQEASVASPFTSRTPSIACVPELIREGRAALVTSFCMFKYMALYSTIQYLGVLLLYWQLNSFGNYQFLFQDLAITTVIGMTMSFTEAYPKLVPYRPPSQLVSPPLLLSVILNILFSLGMQILGFLMVQKQPWYSKTDIHSACLSVNNHVENSSSASSLGLHGVGGGDPTEVDNGYKSYENTTVWLLSTINCLIIALVFSKGKPFRQPIYTNYVFIMVLVGQLGVCLFLVFADIDDLYSKMDLVCTPTTWRISMVMMLAVTLAVSFLVEEAIIENRALWLWLKKTFQYHSKSHYKRLQRVLEQDSAWPPLNETFSLDAVTVSVEEDMEGHSNPTFDSNEDAL
What are the official names of this protein?
Probable cation-transporting ATPase 13A4, P5-ATPase isoform 4.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MNMA_SALAI
Sequence: MVAVRVLAAMSGGVDSAVAAARAVAAGHDVTGVHLALARNPQTYRTGARGCCTLEDSRDARRAADVIGIPFYVWDMAERFQADVVDDFVAEYAAGRTPNPCLRCNEKIKFAAVLDRAVALGFDAVVTGHHARLGADGLLRRSVDLAKDQSYVLGVLTREQLGRSMFPLGDSTKTQVRAEATGRGLTVADKPDSHDICFVADGDTRGFLAERLGATPGDVVDSSTGAVVGRHTGAYAYTVGQRRGLHLDRPAPDGRPRYVLSITPKTNTVTVGPAEALAVSQVRAQRPVWTGGPRPADPIECEVQLRAHGDVVPATVAVTGDGLRAELHRPVRGVAAGQAIVAYRPDPGGDVVLGSATIAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.