PharMolix/UniProtQA huggingface dataset:
Protein: CSPLN_MAIZE
Sequence: MAGLAGRPGSWGGLVLRVGQALFAAACIGVMGSSLGFASYTAFCYLIASMGLQMLWSFGLACLDGYAIRANKDLTSPILLSLFVVGDWVTAILSFAASSSAAGVVILFQKDVLFCRRYPQLPCGKYELATAFAFLSWALSATSALIMFWLLAAF
What are the official names of this protein?
CASP-like protein 5B2, ZmCASPL5B2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TACY_CLOPE
Sequence: MIRFKKTKLIASIAMALCLFSQPVISFSKDITDKNQSIDSGISSLSYNRNEVLASNGDKIESFVPKEGKKTGNKFIVVERQKRSLTTSPVDISIIDSVNDRTYPGALQLADKAFVENRPTILMVKRKPININIDLPGLKGENSIKVDDPTYGKVSGAIDELVSKWNEKYSSTHTLPARTQYSESMVYSKSQISSALNVNAKVLENSLGVDFNAVANNEKKVMILAYKQIFYTVSADLPKNPSDLFDDSVTFNDLKQKGVSNEAPPLMVSNVAYGRTIYVKLETTSSSKDVQAAFKALIKNTDIKNSQQYKDIYENSSFTAVVLGGDAQEHNKVVTKDFDEIRKVIKDNATFSTKNPAYPISYTSVFLKDNSVAAVHNKTDYIETTSTEYSKGKINLDHSGAYVAQFEVAWDEVSYDKEGNEVLTHKTWDGNYQDKTAHYSTVIPLEANARNIRIKARECTGLAWEWWRDVISEYDVPLTNNINVSIWGTTLYPGSSITYN
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol-containing host membranes.  After binding to target membranes, the protein assembles into a pre-pore complex.  A major conformational change leads to insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host cell membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Can be reversibly inactivated by oxidation.
What are the official names of this protein?
Perfringolysin O, PFO, Theta-toxin, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein that then inserts into the host cell membrane and forms huge pores formed by transmembrane beta-strands.
Protein: RRBP1_HUMAN
Sequence: MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEVPMVVVPPVGAKGNTPATGTTQGKKAEGTQNQSKKAEGAPNQGRKAEGTPNQGKKTEGTPNQGKKAEGTPNQGKKAEGTPNQGKKAEGAQNQGKKVDTTPNQGKKVEGAPTQGRKAEGAQNQAKKVEGAQNQGKKAEGAQNQGKKGEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGQKGEGAQNQGKKTEGAQGKKAERSPNQGKKGEGAPIQGKKADSVANQGTKVEGITNQGKKAEGSPSEGKKAEGSPNQGKKADAAANQGKKTESASVQGRNTDVAQSPEAPKQEAPAKKKSGSKKKGEPGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLLSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGTSV
What is the function of this protein?
Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.
What are the official names of this protein?
Ribosome-binding protein 1, 180 kDa ribosome receptor homolog, RRp, ES/130-related protein, Ribosome receptor protein.
Protein: Y605_YERPS
Sequence: MLIIISPAKTLDYQSPLATTKFSQPEMLDKSQALIEICRELTPAQISSLMGISDKLAGLNAARFSEWQPDFTPANARQAILAFKGDVYTGMQAESFSEADFDFAQQHLRMLSGLYGLLRPLDLMQPYRLEMGTKLANPRGKDLYAFWGDQITEKLNQALELQGDNILINLASDEYFKAVKPAKLSGSLIKPVFLDEKNGKYKIISFYAKKARGLMSRFIIQNKLTKPEQLVDFNLEGYEFDAGLSAKNELVFKRAEQH
What are the official names of this protein?
UPF0246 protein YPTB0605.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: PRIO_PLEMO
Sequence: MLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGSWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHNQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYEKESQAYYQRGSSMVLFSSPPVILLISFLI
What is the function of this protein?
Its primary physiological function is unclear.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: PCDG2_PANTR
Sequence: MAALQKLPHCRKLFLLCFLLATLWEARAGQIRYSVREEIDRGSFVGNIAKDLGLEPLALAEQGVRIVSRGRSQLFALNPRSGSLVTANRIDREELCAQSAPCLLNFNILLEDKLTIYSVEVEITDINDNAPRFGVEELELKISETTTPGFRIPLKNAHDADVGENALQKYALNPNDHFSLDVRSGADGNKYPELVLERALDREEEAVHHLVLVASDGGDPVLSGTSRICVKVLDANDNAPVFTQPEYRISIPENTPVGTRILTVTATDADEGYYAQVVYFLEKSPGETSEVFELKSTSGELTIIKDLDYEDATFHEIDIEAQDGPGLLTRAKVIVTVLDVNDNAPEFYMTSATSSVSEDSLPGTIIGLFNVHDRDSGQNAFTTCSLPENLPFKLEKSVDNYYRLVTTRALDREQFSFYNITLTAKDGGNPSLSTDAHILLQVADINDNAPAFSRTSYSTYIPENNPRGASVFSVTAHDPDSNDNAHVTYSFVEDTVQGAPLSSYISINSDTGVLYALRSFDYEQLRDLQVWVIARDSGNPPLSSNVSLSLFVLDQNDNPPEILYPAFPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYHLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADRIPDILADLGSLEPSAKPNDSDLTLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGSLTGMQSSHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCEKKDFLSAPQSLLEEEREETFSQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin gamma-A2, PCDH-gamma-A2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PHAG1_MOUSE
Sequence: MGPAGSVLSSGQMQMQMVLWGSLAAVAMFFLITFLVLLCSTCDREKKPRQHSGDHENLMNVPSDKDMFSHSATSLTTDALASSEQNGVLTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKAKCHQSRELPRIPPENAVDEILTARAADTELGPGVEGPYEVLKDSSSQENMVEDCLYETVKEIKEVADKGQGGKSKSTSALKELQGAPMEGKADFAEYASVDRNKKCRHSANAESILGTCSDLDEESPPPVPVKLLDENANLPQEGGGQAEEQAAEGTGGHSKRFSSLSYKSREEDPTLTEEEISAMYSSVNKPGQSAHKPGPCMKGPESACHSMKGLPQRSSSSCNDLYATVKDFEKTPNSISTLPPARRPSEEPEPDYEAIQTLNREDEKVPLETNGHHVPKESDYESIGDLQQCRDVTRL
What is the function of this protein?
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.  Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition.  Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins.  May be involved in cell adhesion signaling.
What are the official names of this protein?
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Csk-binding protein, Transmembrane phosphoprotein Cbp.
Protein: HERA_SACS2
Sequence: MIIGYVIGQATTQEALILAERPVRLGTYVVLEYDNVKALGLITNVTRGSPMLDDNMNDIEIVQRLKQFNNSIPVYTKAKVKMLCDMNNHFLMPDIPPFAGTPAREAEDEELKSIYSQDGQIRIGSLIGKNVEVKLNINSFARHLAILAATGSGKSNTVAVLSQRISELGGSVLIFDYHGEYYDSDIKNLNRIEPKLNPLYMTPREFSTLLEIRENAIIQYRILRRAFIKVTNGIREKLKEGQIPFSTLNSQFYELMKDELETQGNSDKKSSAKDEVLNKFEEFMDRYSNVIDLTSSDIIEKVKRGKVNVVSLTQLDEDSMDAVVSHYLRRILDSRKDFKRSKNSGLKFPIIAVIEEAHVFLSKNENTLTKYWASRIAREGRKFGVGLTIVSQRPKGLDENILSQMTNKIILKIIEPTDKKYILESSDNLSEDLAEQLSSLDVGEAIIIGKIVKLPAVVKIDMFEGKLLGSDPDMIGEWKKVEESEKIAKGFADFGTEIGD
What is the function of this protein?
Involved in DNA double-strand break (DSB) repair (PubMed:22135300).  Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity).  Exhibits DNA-dependent ATPase activity and DNA helicase activity (PubMed:22135300, PubMed:25420454).
What are the official names of this protein?
DNA double-strand break repair helicase HerA.
What is the protein family that this protein belongs to?
Belongs to the HerA family.
Protein: FPG_MYCSK
Sequence: MPELPEVEVVRRGLDAHVTGKAITAVRVHHPRAVRRHEAGPADLTARLLGMRITGTGRRGKYLWLTLDDGDEPLARRAESSVALVVHLGMSGQMLLGPIPKEDHLRIAALFDDGTALSFVDQRTFGGWLLADLVTVDGTDVPVPVAHVARDPLDPRFDRDAVVKVLRGKHSEIKRQLLDQTVVSGIGNIYADEALWRAKVNGARLAESLTKPKLAEILDHAADVMRDALGQGGTSFDSLYVNVNGESGYFDRSLDAYGREGEPCRRCGAIMRRDKFMNRSSFYCPRCQPRPRVRRA
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RS15_XENLA
Sequence: MAEVEQKKKRTFKKFTYRGVDLDQLLDMSYEQVMQLYCARQRRRLNRGLRRKQNSLLKRLRKAKKEAPPMEKPEVIKTHLRDMIILPEMVGSMVGVYNGKAFNQVEIKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
40S ribosomal protein S15, RIG protein.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: UVRB_MYCMS
Sequence: MLWEKVMFIANNKYKLVTKYKPSGDQNQAIEKLNKAIIENKKHQVLLGATGTGKTFTIANIIAKHNKQALVIAHNKTLAMQLYYELKEMFPENRVEYFVSNFDFFQPEAYIPSKDLYIDKDSRQNMELDMMRLSACNALLTRNDTIVVASVAALFALQNPLEYSSAFIELKVGQKIKRNELLTWLVRSGYTRNDIENQLGSFSAKGDVVKIVPGWVNNIMFRISLFDDEIESIHTLNTITNSILDNITTVTIHPAQSYITPQDKLKTICNNIRNELVQRLAELQSENKLLEAQRLEQRTKYDLESLEEFGFCSGIENYSSHLDFRSKGQRPYVLLDYFNNDFITIVDESHITLPQIRGMYNTDRSRKLTLVEYGFRLPSALDNRPLNFDEFNSLIKQVIYTSATPGDYELDLVNHQVVQQIIRPTGLLDPQIEIRKTTNQIDDIINEIHLRKLQNERVFITTLTIRMSEDLTAFLQEKNIKVAYLHSELKTLERSEILNDLRKGVYDVVVGVNLLREGLDLPEVSLVCILDADKQGFLRNYRSLIQTIGRVARNVNGKAIMYADTVSQAMDEAIKETNRRRKIQEEFNKKHNIVPKTISKAISESILSEQTKKTLAKAKKIKDKKQKLQTIQQTIDNLRQEMLQAAKELDFERAAILRDTIIELENEKNTN
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_CAEEL
Sequence: MSVVSNHHSNGNGNSTVYDTNGNDEIKKEVKDEPMASDSEVPFGELMKRDKKEKKQKKRKAESGSDEDDYKPEKRKSSAKNGKKKDVGSDSEDDYKPEKKKSKKNNKKKAQESSEDDDEESEGDVSEEDVKPQIHSDDELEEEDEAPTTDDEEEQKRKEKERRKKEKREKKERKEKKRLEKENRKIKEEDDEDSDDEDDEKAKKKKRKSKGAEKSKPSTSKKDAGGKKEPPKKKVKKEEDIEDIWEWWKEEKKPAGVKWNSLQHCGPLFAPPYIPLPSHVHFKYGGEKMKLTLETEEIAQFYAGVLDHEYSTKEAFNKNFMKDWRKVMTVEERERIHDLKKCDFRAIDAYQKEQREIRKAMTKEEKLKIKEEKEAEVKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKMGLIKKRIMPEDVIINCGKDTEIPKPPPGHKWKEVRHDNTVTWLCSWTESVLGQNKYIMLNPSSKIKGEKDFEKYETARRLKKKIGGIRERYTDDFKSKEMRVRQRATALYFIDKLALRAGNEKDVDEAADTVGCCSLRVEHIKLFDSAKLNEDDKKEKEFVVEFDFLGKDSIRYFNRVSVEKRVYKNLKIFMEGKAPSDDLFDRLDTATLNDHLRSLMDGLTVKVFRTYNASITLQEQLIKLTNPKDNVAAKILSYNRANRQVAILCNHQRAVSKGFDESMQKLEQKIKDKKKEVKEAEAALKSARGAEKEKAQKKYDRLKEQLKKLKISRTDKDENKQIALGTSKLNYIDPRITVAWCKKFEVPLEKVFTKTHREKFRWAIDMTNSSDEEYVF
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).  Required for normal spermatogenesis and oogenesis (PubMed:16943775).
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, topoI.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Chromosome. Note=Localizes around sperm chromatids.
Protein: FLGI_LEGPC
Sequence: MRRMLVIRWILAIHLIATQVFAERIKDIATLAGVRVNQLVGYGLVVGLSGTGDKTGTKFTEDSFANMLTQLGINVPPGVRLNSKNIAAVMVTANLSSFMKKGQTMDVNISSIGDSKSLLGGTLLLTPLKGADGRVYAMSQGNVVVSGISASGSDGSSVTVNVPSGGRIPNGATIEADIPNPFYYSNSLTYNLHTPDFTTAKRMSDAINELMGPGTAKAIDAGSVVVTAPKKLSQRVDYVSVLENIEFKPGEAMAKIIINARTGTVVISSNVIVKSAAVSHGNLVVSITETPVISQPNAFASGRTVATQQSQVNIQQKNNRAFILPKGTTLKDIVRGINAVGATPADVISILEALQQAGALSATLIVI
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: RLME_LEPCP
Sequence: MKINTKSKKVNKAWFNDHIHDTYVKLAHKEGYRSRAAYKIKEIDETCGLIRPGQVVVDLGAVPGAWSQYVRRRFAPREAGVGGAAAGELNGRIIALDLLPFEPLEGVAFLQGDFCEEAVLAQLVGLLDGRAVDVVLSDMAPNLSGVEVTDAARIANLVELALEFAQSHLKPQGALVCKVFHGSGYSQLVDQFKRTFRVVKAVKPKASRDRSAETFLVGIGLKSTGMPNADAV
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPTA_META3
Sequence: MFCDVQATEPDVKVSLTRVGITNLKKLIKITRESKRPIILLPTFEVFVDLPSSQKGIHMSRSPEVIEEIIESMVDNEVYGIEELSVDIIKKLFEKHEYATRAEVLMYGEYMMEEESPITKRSSQEICKIMSKAHGTKDGNNNIIIKKMVGAEVVGITACPCAQNLLKEKAIKKLKEKGFSDEDIKNILDSVSIATHNQRGIGTIMIEVPDGYEVGISKIINIIKKSMSGEVYELLKRVDEGYVVEEAHKNPKFVEDCAREMIRRVVGEFNYLPDDTEVLVRQVNKESIHRHDAFAERSSTLGELRNELK
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: CYB_MOSMO
Sequence: MTNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYTFLETWNIGVILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAMVHLLFLHETGSNNPTGITSDMDKIPFHPYYTIKDILGILLLILILMALVLFTPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILIFMPLLHTSKQRSMMFRPLSQCLFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFLLILVMMPVASMVENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL6_LACP3
Sequence: MSRIGYKVIKVPAGVTITKDGDNITVKGPKGELTRHFAPEIEMHQEGDEINFTRPDDSYKAVHGTMRANLNNMVVGVTEGYKKEMKLVGVGYRAQKQGEKLVLNVGYSHPVEMTAPKGVTVEVPSTTQIIISGISKQVVGQFAAVVRSVRAPEPYKGKGIRYVDEHVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: TRPA_METM7
Sequence: MNKPVLVSFLVSGDPNPDATLKFMKALDKYSGVIELGIPFSDPVADGPTIQAADVRALSNGFKIAKSFEVLKEFRKESDTPVILMTYYNPVFKRGIETFVMQAKEAGANGLIIVDLPLQEATEYREICKKHEMGTVFLAAPNTPEERLKISDEASTEFLYLISTFGITGARESFEQMTFDFIKRARTTCKGKICVGFGISKGSHAESLIEQGADGVIVGSAFVDIIKNYGDSEEALVKLEELAKELSEGIEKGYEKRNK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: TRPD_STAES
Sequence: MTLLEKIKQNKSLSKKDMQSFIVTLFDSNIETNVKVELLKAYTNKDMGQYELTYLVEYFIQTNYPNQPFYNKAMCVCGTGGDQSNSFNISTTVAFVVASAGVPVIKHGNKSITSHSGSTDVLHEMNIKTNKMNEVEQQLNLKGLAFISATDSYPMMKKLQSIRKSIATPTIFNLIGPLINPFKLTYQVMGVYEASQLENIAQTLKDLGRKRAILIHGANGMDEATLSGENIIYEVSSERALKKYSLKAEEVGLAYANNDTLIGGSPQTNKQIALNILSGTDHSSKRDVVLLNAGIALYVAEQVESIKHGVERAKYLIDTGMAMKQYLKMGG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: IBMP_CSVMV
Sequence: MEDMMKQILEKLNTIEKNISETNIRIEKIEKEQELKRKVELYGKEPEKKLHKENIEKLSSSIEDKIIQNIDKKLKKIENVEEQYQWKNIVKINKPLSVGEKYMENFKKILVYLGEKHPKLEELYSLTDYNKLVADIYTDRNLVISAYNYGLLQVLYIEHPSQLELFDENIKLAYMKFRNVTKAQLIYMRIYSAMAEPYDKGVIPKIEIIKFGITYSKLKYDEVYEHQPIEKLDLKKFISQKRALGILVIQKEIENLNGNVWLYSNLDGRLILSNHNKAENVEVKNILSDWSKKLSIPEGNYPRCSIKNPMFTGKTMEVLCELSKKQINMRHICNLCSKMKNVQIQDPILPEYEEEYVEIEKEEPGEEKNLEDVSTDDNNEKKKIRSVIVKET
What is the function of this protein?
Enhances the translation of downstream ORFs on polycistronic mRNAs derived from cassava vein mosaic virus.
What are the official names of this protein?
Putative transactivator/viroplasmin protein, Tav, Inclusion body matrix protein.
What is the protein family that this protein belongs to?
Belongs to the caulimoviridae viroplasmin family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in cytoplasmic occlusion bodies.
Protein: HTPX_ECOL6
Sequence: MMRIALFLLTNLAVMVVFGLVLSLTGIQSSSVQGLMIMALLFGFGGSFVSLLMSKWMALRSVGGEVIEQPRNERERWLVNTVATQARQAGIAMPQVAIYHAPDINAFATGARRDASLVAVSTGLLQNMSPDEAEAVIAHEISHIANGDMVTMTLIQGVVNTFVIFISRILAQLAAGFMGGNRDEGEESNGNPLIYFAVATVLELVFGILASIITMWFSRHREFHADAGSAKLVGREKMIAALQRLKTSYEPQEATSMMAFCINGKSKSLSELFMTHPPLDKRIEALRTGEYLK
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ADD_ECODH
Sequence: MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVREGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVAELAAHPLKTFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: ER10B_ASPFC
Sequence: MSSLPAVYIVSSARTPVGSFLGSLSSLTAPQLGAHAIKAALAKVDGLKPSDVQEVFFGNVISANVGQNPARQCALGAGLEESTICTTVNKVCASGLKAIILGAQTIMTGNADVVVAGGTESMSNAPHYLPNLRTGAKYGHQSLVDGIMKDGLTDAGKQELMGLQAEECAQDHGFSREQQDEYAIRTYEKAQAAQKAGLFDEEIAPIQLPGFRGKPDVTVTQDEEPKNLNPEKLRAIKPAFIPGSGTVTAPNSSPLNDGAAAVVLVSEAKLKELNLKPVAKILGWGDAAQQPSKFTTAPALAIPKALKHAGVGQDAIDAFEINEAFSVVALANMKLLGIPEEKVNLHGGAVAIGHPIGASGARILTTLLGVLKAKKGKLGCAGICNGGGGASALVVELL
What is the function of this protein?
Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:32005728) (Probable).  In this module, the cytosolic acetyl-CoA acetyltransferase erg10B catalyzes the formation of acetoacetyl-CoA (PubMed:32005728).  The hydroxymethylglutaryl-CoA synthases AFUA_8G07210 and AFUA_3G10660 then condense acetyl-CoA with acetoacetyl-CoA to form HMG-CoA (Probable).  The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases hmg1 and hmg2 (PubMed:22106303, PubMed:30940706).  Mevalonate is also a precursor for the extracellular siderophore triacetylfusarinine C (TAFC) (PubMed:22106303).
What are the official names of this protein?
Acetyl-CoA acetyltransferase erg10B, cytosolic, Acetoacetyl-CoA thiolase erg10B, ACAT, Cytosolic thiolase erg10B, CT, Ergosterol biosynthesis protein 10B.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.