PharMolix/UniProtQA huggingface dataset:
Protein: NUOA_PARP8
Sequence: MRIALNLAAYFPVLMFLLVGTGLGVALVSIGKILGPNRPDTEKNAPYECGFEAFEDARMKFDVRYYLVAILFIIFDLETAFLFPWGVALRDIGWPGFISMMIFLLEFLLGFAYIWKKGGLDWE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LAP1_COCP7
Sequence: MKSLSLLALAAIAPPAAVAAVVDRQVPFENRPVQGLPEKFLIQLGPEQTRWVTEDEKWALKMEGVNFFDITAEPDRGFSAKSHERIQVSFPSEVKHQTELAPLLEQLSKDNMRQNLVHFTSFHTRYYKSETGVQSATWLFEQVEEAIQDSGAAQHAVKVERFEHSWGQFSIIATIPGRTNKTVVIGAHQDSINLFLPSILPAPGADDDGSGTVTILEAFRVLLQSEAVQQGNAANTIEFHWYSAEEAGLLGSQAIFSDYSKTGRDIKAMLQQDMTGYVEGTTKAGEVESVGVITDFVDPGLTEFIKRVITGYCTIPFVLTQCGYACSDHASASRYGYPSAFVIESEFKRSNQRIHTTGDTVDLLSFDHMLQHARMTLAFAYELAFAEL
What is the function of this protein?
Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.
What are the official names of this protein?
Leucine aminopeptidase 1, Leucyl aminopeptidase 1, LAP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28E subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DLG1_DROME
Sequence: MPVKKQEAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADFIKSSNLNRNCAYEFNNDASSNQTNQSALNQNPIANNVSAQAQAEALSRTFKSELEEILNQRMRIESDTENAKEPTVEQQQKQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQDDANAEGASEENVLSYEAVQRLSINYTRPVIILGPLKDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFIKPKSVDSVMEMNRRMTEEQAKKTYERAIKMEQEFGEYFTGVVQGDTIEEIYSKVKSMIWSQSGPTIWVPSKESL
What is the function of this protein?
During embryonic development, some isoforms are essential for proper neuronal differentiation and organization.  Required for cell polarity; maintenance of apicobasal polarity.  Plays a critical role at septate junctions in cellular growth control during larval development.  The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
What are the official names of this protein?
Disks large 1 tumor suppressor protein.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, septate junction. Note=Cytoskeleton- and membrane- associated. Located at the cytoplasmic face of the membrane in the cellular blastoderm and becomes associated with septate junctions which begin to form between epithelial cells at the time of dorsal closure. In adult flies, located at the apical-lateral membrane boundary of epithelial cells.
Protein: CYNS_METFK
Sequence: MSRLDVTEKIITAKVMKGLKWADVAAKLNLSKEWVTAACLGQMTLNAEQAKIIAEIFDLSDEDQKWLMVTPCKGSLPTAVPTDPLIYRFYEMINVYGTTIKQLIHEEFGDGIMSAIDFKMDLQRVADPMGDRVNIVLNGKFLPYKQF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: RPOB_STREM
Sequence: MAGHDVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFQDFLDSGLKEVFEDVLPISNFTDTMELEFVGYEFKEPKYTLEEARIHDASYSAPIFVTFRLINKETGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVIPNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIIDIFGDSELVRNTIEKDIHKNQSDSRTDEALKEIYERLRPGEPKTADSSRSLLTARFFDARRYDLAAVGRYKINKKLNIKTRLLNQIIAENLIDSETGEILVEAGTEMTRSVIESIEEQLDGDLNKFVYTPNDYAVVTEPVILQKFKVVSPVDPDRVVTIVGNANPDDKVRALTPADILAEMSYFLNLAEGLGKVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNDVLTPQQIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSSFGHLNKYGFIQTPYRKVDRVIGRVTNEIVWLTADEEDEFTVAQANSKLNPDGTFAEEIVMGRHQGNNQEFPASQVDFVDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLIDPKAPYVGTGMEYQAAHDSGAAVIAQHNGKVVFSDAERVEVRREDGSLDVYHITKFRRSNSGTAYNQRTLVKIGDIVEKGDFIADGPSMEKGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKEDVYTSVHLEEFESETRDTKLGPEEITREVPNVGEEALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGGDGIVRDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIHIATPVFDGATSEDLWETVREAGMDSDAKTVLYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVLQEILTYKSDDVNGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDNEVELRDLDEGEDDDVMHVDDLEKAREKQAQETQDIAESTEDN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RS7_LEPCP
Sequence: MPRRREVPKREILPDPKFGSVDLSKFMNVIMESGKKAVAERIIYGALEQVEKKAGKDPMEIFLTALNNVKPMVEVKSRRVGGANYQVPVEVRPIRRMALAMRWLKESARKRSEKSMAQRLANELMEACEGRGGAMKKRDEVHRMAEANKAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: NACA_YARLI
Sequence: MSAENKIEEITEDQVPQIEENSTIVIKKEEKAARALISKLNLQKVEGITRVVLKRTRQHIFVIANPEVYKTPTGNSYVVFGEAQHEDMQATARAAQIAAAQAQQAAAETGSVSEAAAAGEVGAELASKDPASITADLEAASLSKDEDAEDEAEADATGLEDSDIKLVMEQANVSRNKAINGLKKNDSDVVNTIMDLCK
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD2 may also be involved in transcription regulation (By similarity).
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: MSRB_PSEPW
Sequence: MQKIDKTLEEWRAMLDPEQYQVCRLKGTERPFTGKYNSEKRAGTYHCICCDLPLFDSNTKFDSGCGWPSFYAPIEDSAMIETRDTSHGMIRTEVTCAQCDAHLGHVFPDGPPPTGLRYCINSVCLDFKPRDGA
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: F16PA_NEIG1
Sequence: MDTLTRFLPEHLQQNQLPEALGGVLLSVVSACTEINAKVRLGALAGVLGMAGTGNIQGEDQKKLDVIANNIMIDTLKANPAVAGLASEEEDTFVSAGENGRYLVLFDPLDGSSNIDVNISVGTIFSILAKPEGALATESFLQTGRQQLAAGYVLYGPQTQLVFTFGHGVYVFTLNAENEFVLTKENPKVPESTKEFAINMSNRRHWLPPVQQYVDELLAGETGTRGKNYNMRWVASMVAEIHRILMRGGVFMYLQDKRDPSKPGKLRLMYEANPMALILEQAGASASNAYQAMLDIQPESLHQRVAVIMGSSEEVDYLNRLHSK
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P32_MCMVK
Sequence: MPSPCTYGDPTFNSRILEAVVADVLGGTEDDGGPSLEEWFDAQTLSDYTNCATDPPMATVHTRENDIKSWTELSENFPDLVRYPESLVETLLDTEHECGHFYDAPDSFQISVTAMFTDRCKCQFCDPNFQARSLSRALLGPLPESGDDAEWMEQAYTPDAELFVNEPTDDPIPTTDCKRPIQPTWSVDVYSKQVDSDWGLSDSTNVTVCSASSSLLPAGRGGIYFMCPRPEGIERVCLQVGAKIRSGAPNSGTITNLPGGTGYGTEWSDDGYETQWSDGPYSIPSGLSD
What are the official names of this protein?
Uncharacterized protein p32.
Protein: Y854_RICPR
Sequence: MFEKYIMYLKNLIFFQFIVYFFFISLTILIIKNFQQEYSKSILDKQVAQENLTEEVLKLYSVINSKEEILESYKKYVALSVPKNSVSCLNYQELIPRIKSLGSKYNLVEPIDVSINSVFFKNNVQVIEGENESIHVNNYSINIKYACADFLTFLKIFSEIYSYMPPNTLISFVRVRNEEVLTPKNIYKLSVNHAPNLIYTKLILYIRELSSK
What are the official names of this protein?
Uncharacterized protein RP854.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DPO1_CHLAA
Sequence: MAYPLLVLVDGHALAYRAFFALRESGLRSSRGEPTYAVFGFAQILLTALAEYRPDYAAVAFDVGRTFRDDLYAEYKAGRAETPEEFYPQFERIKQLVQALNIPIYTAEGYEADDVIGTLARQATERGVDTIILTGDSDVLQLVNDHVRVALANPYGGKTSVTLYDLEQVRKRYDGLEPDQLADLRGLKGDTSDNIPGVRGIGEKGAIALLKQFRSLDALLEQIDAAPKRYQTLLREQAEAARFSRQLATIVTDVPVQLDLEAARIGVYDRSAVMALFQELEFGVSSNLIKKLPSVVQAPTLAELPADLPAAPLTTAPTQLSLFAGESEPAQPTAEPPPVTIVRDATALADLVSRLRNAPAFAFDTECTSLQPVASDLVGISIAIAPDTVCYIPVGHQSETQVPCGEVVTALAPFFANPQQPKFAHNAKFDMEVLAGAGIKVSGLAFDTMIAAAMLGKRQGLKDLAFYELKLPEPPTTIEDLIGRGNKQISFAEVPVEQAAPYAAADALYTLRLTERLQRQLEAEPALHDLYYRVELPLIEVLTDMELTGIRLDQEYLRELGRHFAQRIADLVERIYQQAGGPFNINSGQQLNDVLFGRLGIDPRAHGLSKLKSGGYSITAEVLEELSQLYPIAADILTYRQLTKLKSTYIDALPDLVNPRTGRIHTSYNQLGAATGRLSSNNPNLQNIPVRTEEGREIRRAFVAEPGWRFVAADYSQIELRVLAHMSGDENLIAAFQQGLDIHAATASRLFGVEPTAVDKNQRRVAKTVVFGVIYGISAFGLAQRLGIERDLARQLIDNLFAQFPGIRRYIDQTLEFGRQHGYVQTLFGRRRVMEDLRASGARRAAAEREAINAPIQGTAADLMKMAMVNVHRALREQGLRTRLLLQVHDELIAEAPEDEVEPAARLLRDVMSSVYRDLVVPLSVNLEVGPNWDEMSPLAMG
What is the function of this protein?
In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
What are the official names of this protein?
DNA polymerase I, POL I.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-A family.
Protein: NQRA_YERPG
Sequence: MIKIKKGLDLPIAGAPVQTIQDGPAIHHVALLGEEYVGMRPSMLVQEGDQVKKGQALFEDKKNPGVLFTAPASGKISAINRGERRVLQSVVIEVEGDEQIPFEHYAAEELNQLSDEQVQHHLLTSGLWTALRTRPFSKTPVPGSRPRAIFISAMDTQPLAADPQVIIATESEAFNHGLTVLTRLTDGKVHVCHAAGQAVTRHTNTQVTYNEFSGPHPAGLVGTHIHFLEPVSQTKMVWHVGYQDVIAIGKLFTRGELCTDRIVALAGPQVNQPILLRTRLGASLSELTAGKLKEGDNRIISGSVLSGTAFSATHGYLGRFHQQVSVIREGREKELFGWVMPGRDKYSITRTTLGYFFKRKLFAFSTDMHGGERAMVPIGNYERVMPLDILATHLLRDLLAGDTDSAQALGCLELDEEDLALCTFVCPGKYEYGPVLRDILTQIEQEG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit A, Na(+)-NQR subunit A, Na(+)-translocating NQR subunit A, NQR complex subunit A, NQR-1 subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrA family.
Protein: ZN263_HUMAN
Sequence: MASGPGSQEREGLLIVKLEEDCAWSQELPPPDPGPSPEASHLRFRRFRFQEAAGPREALSRLQELCHGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQRELGRLRQQVTNHGRGTEVLLEEPLPLETARESPSFKLEPMETERSPGPRLQELLGPSPQRDPQAVKERALSAPWLSLFPPEGNMEDKEMTGPQLPESLEDVAMYISQEEWGHQDPSKRALSRDTVQESYENVDSLESHIPSQEVPGTQVGQGGKLWDPSVQSCKEGLSPRGPAPGEEKFENLEGVPSVCSENIHPQVLLPDQARGEVPWSPELGRPHDRSQGDWAPPPEGGMEQALAGASSGRELGRPKELQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAERLCMGVDCTEIFGGNPRFLSLHRAHLGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPYQCNICGKCFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCPECGKSFSRSSHLVIHERTHERERLYPFSECGEAVSDSTPFLTNHGAHKAEKKLFECLTCGKSFRQGMHLTRHQRTHTGEKPYKCTLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLMSHQRTHTG
What is the function of this protein?
Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553).  Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553).  Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030).
What are the official names of this protein?
Zinc finger protein 263, Zinc finger protein FPM315, Zinc finger protein with KRAB and SCAN domains 12.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CITX_ECO5E
Sequence: MHLLPELASHHAVSIPELLVSRDERQARQHVWLKRHPVPLVSFTVVAPGPIKDSEVTRRIFNHGVTALRALAAKQGWQIQEQAALVSASGPEGMLSIAAPARDLKLATIELEHSHPLGRLWDIDVLTPEGEILSRRDYSLPPRRCLLCEQSAAVCARGKTHQLTDLLNRMEALLNDVDACNVN
What is the function of this protein?
Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.
What are the official names of this protein?
Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, Apo-ACP nucleodityltransferase, Holo-ACP synthase, Holo-citrate lyase synthase.
What is the protein family that this protein belongs to?
Belongs to the CitX family.
Protein: HRCA_BACP2
Sequence: MLTNRQLLILQVIINDFIRSAQPVGSRTLSKKEDITFSSATIRNEMADLEELGFIEKTHSSSGRIPSEKGYRYYVDHLLSPRKLSSNELVLIQSAFQEKIFELEKTVQKSAEILSDLTNYTSIVLGPKLSENRLKQIQLVPVQPNKAVAIMITDSGHVENKTITFSEHLDVSDIEKLMNILNSRLAGVPMDQLKDRMYKEVVMLLRTHLKDYDHILDALGNTFTSTQNESKLFFGGKINMLNQPEFHDIDRIRSLMMLIEQKNDVMQLFHPNQQGITIKIGSENNLEAMENCSLITATYSIDQKSLGSIAVIGPTRMDYGRVVSLLHHVSKDLSNALSNLYDE
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: UNG_CITK8
Sequence: MATDLTWHDVLADEKQQPYFVNTLHTVAGERQSGMTVYPPQKDVFNAFRFTELGNVKVVILGQDPYHGPGQAHGLAFSVRPGIATPPSLLNMYKELETSIPGFTRPAHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLVNEHREGVVFLLWGSHAQKKGAIIDRQRHYVLRAPHPSPLSAHRGFFGCNHFVLANQWLEQHGEKPIDWMPVLPAESE
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIFA_AZOVI
Sequence: MNATIPQRSAKQNPVELYDLQLQALASIARTLSREQQIDELLEQVLAVLHNDLGLLHGLVTISDPEHGALQIGAIHTDSEAVAQACEGVRYRSGEGVIGNVLKHGNSVVLGRISADPRFLDRLALYDLEMPFIAVPIKNPEGNTIGVLAAQPDCRADEHMPARTRFLEIVANLLAQTVRLVVNIEDGREAADERDELRREVRGKYGFENMVVGHTPTMRRVFDQIRRVAKWNSTVLVLGESGTGKELIASAIHYKSPRAHRPFVRLNCAALPETLLESELFGHEKGAFTGAVKQRKGRFEQADGGTLFLDEIGEISPMFQAKLLRVLQEGEFERVGGNQTVRVNVRIVAATNRDLESEVEKGKFREDLYYRLNVMAIRIPPLRERTADIPELAEFLLGKIGRQQGRPLTVTDSAIRLLMSHRWPGNVRELENCLERSAIMSEDGTITRDVVSLTGVDNESPPLAAPLPEVNLADETLDDRERVIAALEQAGWVQAKAARLLGMTPRQIAYRIQTLNIHMRKI
What is the function of this protein?
Required for activation of most nif operons, which are directly involved in nitrogen fixation.
What are the official names of this protein?
Nif-specific regulatory protein.
Protein: ZN648_HUMAN
Sequence: MAQVDSQDRWGEASPLSSLTEEAHDTQMLSMNLESDDEDGGEAEKEGTADPVACPRGSSPVTHENPDLPWPHPLGKEEEKFSDSSSAGGMGQKPVEMSGKASWSRDVTKINETQGSPGASRALGSLPSGLAHKLLGQMQPLGDRLPAGDDGYSGANQDAVLDVPPSFPSNGKYLCAHKSVDTSAGNSSLLCFPRPGSNWDLPTQETHTPAQASATPASLAAAVLAKARNSRKVQNQAGRREGGEAEARPYRCLRGGRAFQKPSKPLSPAETRGGAAKRYACELCGKAYSHRGTLQQHRRLHTGERPYQCSFCDKAYTWSSDHRKHIRTHTGEKPYPCPDCGKAFVRSSDLRKHQRNMHSNNKPFPCSECGLTFNKPLSLLRHQRTHLGAKPFRCPACDREFAVASRMVEHQRVHSGERPFPCPTCGKCFTKSSNLSEHQTLHTGQRPFKCADCGVAFAQPSRLVRHQRIHTGERPFPCTQCGQAFARSSTLKRHQQIHSGEKGFLCAECGRAFRIASELAQHIRMHNGERPYQCEDCGQAFTRSNHLQRHRAKHGTCKKEPIPSSSDE
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 648.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CACB2_MOUSE
Sequence: MVQSDTSKSPPVAAVAQESQMELLESAAPAGALGAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVRYSAAQEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPQESFDVILDENQLEDACEHLADYLEAYWKATHPPSGNLPNPLLSRTLASSTLPLSPTLASNSQGSQGDQRPDRSAPRSASQAEEEPCLEPVKKSQHRSSSATHQNHRSGTGRGLSRQETFDSETQESRDSAYVEPKEDYSHEHVDRYVPHREHNHREETHSSNGHRHRESRHRSRDMGRDQDHNECIKQRSRHKSKDRYCDKEGEVISKRRNEAGEWNRDVYIRQ
What is the function of this protein?
Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (PubMed:14674701, PubMed:36424916).  Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity).  May modulate G protein inhibition (By similarity).  May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916).  Involved in membrane targeting of the alpha-1 subunit CACNA1C (By similarity).
What are the official names of this protein?
Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2.
What is the protein family that this protein belongs to?
Belongs to the calcium channel beta subunit family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Protein: GLGA_FRATH
Sequence: MRVLHVCSELYPILKTGGLADVTAALPPALAGFGVDSRVLVPGFPAFINAIKDKQLLINIPSRFGAEEINIFLAKIPNTKIDIYVIDAPSLFARPGNPYADSSNQAYADNYLRFALLGWVAARISEGLDAKWKPEIVHSHDWHAGLVPAYIKASELASGKKAVKTVFTVHNLAYQGLFPMSVFTELDLPGIFLSMNGLEFYGQVSFMKAGLYFADKITTVSPTYAKEIQIYEQGCGLEGLLADRHNDLYGVLNGVDPQIWNPKKDSLIATNYSSTTVATGKAKCKLALQQMMGLAEKEDALLFGIVTRLTEQKGLNLLIEAIGEITSRGGQIVLLGSGDKALEEVFLAAAKKYSKSIAVQIGYDEEQAHRIIAGSDVIMVPSRFEPCGLTQLYGLTYGTLPLVHKVGGLADTIIDSSLENLADGTATGFVFDEFSVESLTLAIRRAFALYNRKTDWKKVRKTAMQQQVTWDSSAEKIYQIYKNLVIENN
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: RL9_MANSM
Sequence: MQVILLDKIVHLGNVGDQVNVKSGFARNFLIPQGKAVMATKANIEHFEARRAEIEAKVAAELAAAQARAAQIAALEAVTISSKAGDEGRLFGSITTREIAEAVTAAGVEVAKSEVRLSTGPIRTLGDHEVKFQLHGEVFTALNVIVVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: TRUB_CAMJJ
Sequence: MNKIFAAFKPRGLSSNAFLSTLKKKYKNKKAGYSGTLDPFAKGVLIVAFGQYTKLFRFLKKTPKTYKATLWLGVYSLSLDDQNIKEIKNIKEFDLANLQQIIDQMQGIISYTPPQFSAKRINGTRAYELAKKGIEANLKPCQMEVFDCKILSYNHPFLNIEITVSEGAYIRSYCELFARKLGINATLSSLERIKEGKFVYNNEKSLNVLKYIDLKPNFIKELNKLENGAKIFVEELEFHDEGDYYIETEKYFSIINIKENTVKYLLNKVEKC
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: LIPR2_PIG
Sequence: MLPSWTIGLLLLATVRGKEICYQPFGCFSDETPWARTCHWPFKLFPWAPKDIDTHFLLYTNENPNNFQLINITNLDTIEASNFQLDRKTRFIIHGFIDKGEDSWPSEMCKKMFKVEKVNCICVDWRRGALTRYTQAVHNTRVVGAEIAFLIQGLSTKFDYNPENVHLIGHSLGAHTAAEAGRRLGGHVGRLTGLDPAQPCFQNTPEEVRLDPSDAMFVDVIHTDSAPFIPFLGFGMSQKVGHLDFYPNGGKEMPGCQKNTLSTIVDVDGIWEGIEDFAACNHLRSYKYYSSSIFSPDGFLGYPCASYDEFQEEENKCFPCPAEGCPKMGHYADQFQGKTSAVGQTFFLNTGDSGNFTRWRYRVSVTLAGKRNVHGYIRIALYGSNANSKQYNIFKGSLQPNARYTHDIDVDLNVGKVQKVKFLWYNHIIDLFHPELGASQVMVQSGEDKTEHKFCGSDTVRENILQTLNPC
What is the function of this protein?
Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:23770034).  In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:23770034).  Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:23770034).  Can completely deacylate triacylglycerols (By similarity).  When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase (By similarity).  Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (By similarity).  Hydrolyzes medium- and long-chain fatty acyls in galactolipids.  May act together with LIPF to hydrolyze partially digested triglycerides (By similarity).  Hydrolyzes long-chain monoglycerides with high efficiency (By similarity).  In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity).  Also has low phospholipase activity (PubMed:23770034).  In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity).  The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
What are the official names of this protein?
Pancreatic lipase-related protein 2, PL-RP2, Cytotoxic T lymphocyte lipase, Galactolipase, Triacylglycerol lipase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted. Zymogen granule membrane; Peripheral membrane protein. Cell projection, neuron projection. Note=Localizes to neurite tips in neuronal cells.