PharMolix/UniProtQA huggingface dataset:
Protein: RIMK1_SHEAM
Sequence: MRIAVLSQGPELYSTRRLVEAAKERGHEVRVINPLECYMNINMRASSIHIAGEELPIFDAVIPRIGSAITFYGCAVLRQFEMMGVYTLNESVAVTRSRDKLRSMQLMSRRGIGLPITGFANKPSDIPDLIEMVGGAPLVIKLLEGTQGIGVVLAETRKAAESVIEAFMGLKANIMVQEYIREANGADIRCFVLGDKVVAAMKRQAAPGEFRSNLHRGGSATLVKLTPEERSVAVRAAKTMGLNVAGVDLLRSNHGPLVMEVNSSPGLEGIEGATGKDVAGAIIAFIEKAAHKKPKQTGARG
What are the official names of this protein?
Probable alpha-L-glutamate ligase 1.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: Y066_STRS2
Sequence: MGFTEETVRFRLDDTDKQEISKTLTSVYRSLEEKGYNPINQIIGYVLSGDPAYIPRYNDARNQIRKHERDEIIEELVRYYLKGNGIDL
What are the official names of this protein?
UPF0297 protein SSU98_0066.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: RSMH_SPIKU
Sequence: MEFKHQTVLLQEAISGLNVQNNGIYVDCTLGRAGHSLEILKHLPNGKLYCFEQDEAAIVVSEEILQKSKYRNYEIIKNNFVNLAAELQLRNVKAVNGILYDLGVSSPQLDDDKRGFSYRYDSPLDMRMNQHQGLTAKTVVNTYSQEALVKLFQDYGEEPFAKVIAKTIVIARNEQEIVTTFHLVEIIKKSLPQKILKKAKHPAKRVFQALRIEVNQELFVLQESLRQATTLLAVHGRLVVISFHSLEDRIVKKYFQSLTKDPNYEINQQLPAISYFESDYHIITKKVIVSSVTEQTNNHRSRSAKLRILERVK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLV_EHRCJ
Sequence: MEHKDPSQMYGTTILCIRRGNQVIIAGDGQVSLGQTVIKNSAKKIKRLANDTVITGFAGATADAFTLFERLESKLEKHPGQLLRACVELAKDWRMDKYLRRLEAMMIVADKSISLIISGNGDVLEPENGIAAIGSGGNYALAAAKALCETNERFSQNMTLEYTITTAMRIASEICIYTNNNIIIEKIED
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_SALTY
Sequence: MAKAPVRARKRVRKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: LEA5A_GOSHI
Sequence: MARSVSSFKFLGASVFDALYVSISRRGYSGAPPAAVTASFGRPGAMGKVERRYAMKESSSSETRAYSSAWAPDPVTGYYRPENCGAEIDAADLREMMLNHRVRSQ
What are the official names of this protein?
Late embryogenesis abundant protein Lea5-A.
What is the protein family that this protein belongs to?
Belongs to the LEA type 3 family.
Protein: TCTP_LABRO
Sequence: MIIYKDIITGDEMFSDIYKIKESENGMMIEVEGKMISRAEGEIDDALIGGNASAEVQDEGCESTTVSGVDIVLNHKLQETSYDKKSYTAYIKDYMKAVKAKLQEVAPDRVDPFMANAPAEVKKILGNIKNFQFFTGESMNPDGMIGLLDFREDGVTPYMLFFKDGLEIEKC
What is the function of this protein?
Involved in calcium binding and microtubule stabilization.
What are the official names of this protein?
Translationally-controlled tumor protein homolog, TCTP.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDE6_DROSE
Sequence: MTDVSSPAGGAASPVEMTTSSSPAATTSASSSKPLTNGANKTTISTTAGGVAPGDVPGTGSGAIPASSSSGNQVKLEHHHRQSNNNRPAATNRSSETKLRSPAGESDGASRLMTPAGSSSSPSQSPSQTQASIQTQTSQQDRLTKASTTASQQDVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVARASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQTGFAGLGAGTFGSGRGTGGGSNSNFPGDRVLQIARRTIFFFVPELDAEDDVVDSVVDSVVELSVVVLVLDSVLVAALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKTSLKLLESHVSEDMDDKSPTSPSQPQASGSMGRMSASSSTSSAGGQMVDKSKKRSKLCALL
What is the function of this protein?
Has a role regulating cGMP transport in Malpighian tubule principal cells.
What are the official names of this protein?
cGMP-specific 3',5'-cyclic phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: THIC_MYCBT
Sequence: MTITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLSTGDHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITAEMAFIAAREDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTELTWEIYRDTVIEQCEQGVDYMTVHAGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIFARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIEGPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERDDALSTARFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPKFCSMRITQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNRVYLPITQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: PSAC_PORPU
Sequence: MAHSVKVYDTCIGCTQCVRACPCDVLEMVPWDGCKAKQIASAPRTEDCIGCKRCETACPTDFLSVRVYLGAETTRSMGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: PROA_STUS1
Sequence: MTESVLDYMTRLGRAAREASRVLARASTAQKNRALQAAAAALDAARDELVRANELDLAGGRANGLDAAMLDRLALTPKVIDGMIEGLRQVATLPDPIGAIRDMRYMPSGIQVGKMRVPLGVVGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNQAIARCIQLGLAEAGLPAAAVQVVDTTDRAAVGALISMPDYVDVIVPRGGKGLIERISRDARVPVIKHLDGICHVYVDLAADVDKAIRIADNAKTQRFAPCNTMETLLVHQGIAEQVLPPLAAIYRDKGVELRGCPRTRALLGNEVLAASEEDWSTEYNAPILSIRMLDSLDEAIEHINRYGSQHTDAIVTENFTDARRFLTEVDSASVMINASTRFADGFEYGLGAEIGISTDKLHARGPVGLEGLTSEKYVVFGDGHVRT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
Protein: AAR_SYNE7
Sequence: MFGLIGHLTSLEQARDVSRRMGYDEYADQGLEFWSSAPPQIVDEITVTSATGKVIHGRYIESCFLPEMLAARRFKTATRKVLNAMSHAQKHGIDISALGGFTSIIFENFDLASLRQVRDTTLEFERFTTGNTHTAYVICRQVEAAAKTLGIDITQATVAVVGATGDIGSAVCRWLDLKLGVGDLILTARNQERLDNLQAELGRGKILPLEAALPEADFIVWVASMPQGVVIDPATLKQPCVLIDGGYPKNLGSKVQGEGIYVLNGGVVEHCFDIDWQIMSAAEMARPERQMFACFAEAMLLEFEGWHTNFSWGRNQITIEKMEAIGEASVRHGFQPLALAI
What is the function of this protein?
Catalyzes the NADP-dependent reduction of long-chain acyl-ACP to the corresponding fatty aldehyde.  Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane, by producing the fatty aldehydes used by aldehyde decarbonylase.
What are the official names of this protein?
Long-chain acyl-[acyl-carrier-protein] reductase, AAR, Acyl-ACP reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: OBG_NATTJ
Sequence: MFIDRAKIYVKGGDGGNGIVAFRREKYVPDGGPSGGDGGKGGNVILEVDPGLKSLMDYKYNIHIKGKRGEHGQGSNQHGKSGQDKVIKVPPGTVVKEATSGKVLADLVHEHDSYIAAEGGRGGRGNTRFANPKNKAPRFSEDGKPGEEKWIVLELKVMAEVGLIGYPNVGKSTLLSQVTKASPKIDSYHFTTLNPNLGVVELEEGSRFVMADIPGLIEGAHQGRGLGDQFLRHIERTKMLIHVIDIASIEGRDPVLDIETINEELKGYNSRVMDKPQVIAANKMDLGDQAEENLQRLLDKVNSDEILIPEQYKKIFPISAATGEGLRELLDFVAEKVAQLPDTHDTFDIDLELPESEENTDTEQEALFTMSQDDKIEEKPKSDFGIRKEGDIFIVKHEKLEKILNEIDVHTEKGRHYFQAKVDEFGLEEALVDKGIKPGDTVKIGNVEFEYQ
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL332_STRPI
Sequence: MRVNITLEHKESGERLYLTSKNKRNTPDRLQLKKYSPKLRKHVVFTEVK
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: EFTS_STRP1
Sequence: MAEITAKLVKELREKSGAGVMDAKKALVETDGDMDKAVELLREKGMAKAAKKADRVAAEGLTGVYVHGNVAAVVEVNAETDFVAKNAQFVELVNATAKVIAEGKPANNDEALALVMPSGETLAEAYVNATATIGEKISFRRFALIEKADEQHFGAYQHNGGRIGVISVVEGGDDALAKQVSMHIAAMKPTVLSYTELDAQFIKDELAQLNHAIELDNESRAMVDKPALPFLKYGSKAQLSDDVITAAEADIKAELAAEGKPEKIWDKIIPGKMDRFMLDNTKVDQAYTLLAQVYIMDDSKTVEAYLDSVNAKAIAFARFEVGEGIEKKANDFESEVAATMAAALNN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNR1A_MOUSE
Sequence: MGLPTVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDSLCPQGKYVHSKNNSICCTKCHKGTYLVSDCPSPGRDTVCRECEKGTFTASQNYLRQCLSCKTCRKEMSQVEISPCQADKDTVCGCKENQFQRYLSETHFQCVDCSPCFNGTVTIPCKETQNTVCNCHAGFFLRESECVPCSHCKKNEECMKLCLPPPLANVTNPQDSGTAVLLPLVILLGLCLLSFIFISLMCRYPRWRPEVYSIICRDPVPVKEEKAGKPLTPAPSPAFSPTSGFNPTLGFSTPGFSSPVSSTPISPIFGPSNWHFMPPVSEVVPTQGADPLLYESLCSVPAPTSVQKWEDSAHPQRPDNADLAILYAVVDGVPPARWKEFMRFMGLSEHEIERLEMQNGRCLREAQYSMLEAWRRRTPRHEDTLEVVGLVLSKMNLAGCLENILEALRNPAPSSTTRLPR
What is the function of this protein?
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha.  The adapter molecule FADD recruits caspase-8 to the activated receptor.  The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.
Protein: HSP21_SOYBN
Sequence: MDFRVMGLESPLFHTLQHMMDMSEDGAGDNKTHNAPTWSYVRDAKAMAATPADVKEYPNSYVFEIDMPGLKSGDIKVQVEDDNLLLICGERKRDEEKEGAKYLRMERRVGKLMRKFVLPENANTDAISAVCQDGVLSVTVQKLPPPEPKKPRTIQVKVA
What are the official names of this protein?
17.9 kDa class II heat shock protein.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_MYCMM
Sequence: MAPKKKVAGLIKLQIVAGQANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGTVIPVEITVYEDRSFTFALKTPPAAKLLLKAAGVAKGSAEPHKTKVAKVTWDQVREIAETKKTDLNANDIDAAAKIIAGTARSMGITVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ELA_DANRE
Sequence: MRFFHPLYLLLLLLTVLVLISADKHGTKHDFLNLRRKYRRHNCPKKRCLPLHSRVPFP
What is the function of this protein?
Endogenous ligand for the apelin receptor (aplnra and/or aplnrb) (PubMed:24316148, PubMed:24407481).  Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:24316148, PubMed:24407481, PubMed:26017639, PubMed:29117894).  Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor (PubMed:24316148, PubMed:24407481, PubMed:29117894).  Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells (PubMed:24316148, PubMed:24407481).  May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i. e.  the position of the future vessel formation, during vasculogenesis (PubMed:26017639).  Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting.  Involved in cardioprotective functions during heart failure.  Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity).
What are the official names of this protein?
Apelin receptor early endogenous ligand, Protein Elabela, ELA, Protein Toddler.
What is the protein family that this protein belongs to?
Belongs to the Elabela/Toddler family.
Protein: SAND_TAKRU
Sequence: MDGEAQNESVACEKATLAPVDRLRSNRAESPTPGLVEGTEPGAVQKSAFFAHAQSFEDLTAEAEEKAEQEGVVEDSGQTEDELQVLVGERTITEQHAQDVSPQSRSKEEDMSSEAWRSHRKHVFVLSEAGKPIYTRYGSEEALSSTMGVMMALVSFVESDKNTIRSIHADGCKVIFLAKSPLVLVGVSQTYQSDKELLRELQYIYYQIVSLLTLTQLNHIFQNKQNYDLRRLLAGSEYLTDNLLHRLDRDPGLLLSAVTCLPLSNSVRDVVSSSLQAAKAKNLVFSILLAGDRLVTLVRKKDQFLHHIDLHLVMNLVGSSSSFREGEGWTPICLPKFNTAGFFHAHISYLESASDLCLILVSTDREDFFNMSDCKQRFLERLTKRTAYQALKEALKCPSYSVEQVGIPELRHFLYKSKSSGLYTSPEFPELYQSDEEQERLMGLYQDLHSHLHHPVRPLRFFYRCTNKENLLAWVTNGFQLYLCFSPLGTKAMAVSAVNKLLKWIRKEEDRLFILSPLTY
What are the official names of this protein?
Protein SAND.
What is the protein family that this protein belongs to?
Belongs to the MON1/SAND family.
Protein: MDTL_SALPB
Sequence: MKRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILLIFSVTPNRSVAEHEEIPYQSRP
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPB9_HUMAN
Sequence: MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB9, RNA polymerase II subunit B9, DNA-directed RNA polymerase II subunit I, RNA polymerase II 14.5 kDa subunit, RPB14.5.
What is the protein family that this protein belongs to?
Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Protein: ARAP1_HUMAN
Sequence: MAEAGDAALSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRILAGLLRAHTSPAPAPRPTPRPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLPAAPPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTKEEESLLPSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYDEVPEEGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV
What is the function of this protein?
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members.  Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding.  Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency.  Has a preference for ARF1 and ARF5 (By similarity).
What are the official names of this protein?
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, Centaurin-delta-2, Cnt-d2.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
Protein: UBX4_SCHPO
Sequence: MATIYACRGFHRVPVKLSPSSTLQEVILSSYKQLGFSDWHNLELLHGDKKVDTSLLLRLSGIINGAKLIVKESATNQSGKSSSSISPQSKKIKVALQLPGAARIIDEASSETSIKQLLERHSLLTKVSHVLINGRNFKSEEFDNPLLLYGIREGSILIRLFPIKAQQSIVSEQAPVSQTFNGDVKEKKNADLMDIESENKKDDIVESFPKYPVDAHKLLEPLPTPIPSLPSTPSSYQNLPSQSLTGESLPTVSNQEKDEGVIEKVAVNNTPSVSSKSPFPKKKSFSSMLAQVKKEKAENNGSDGYDLQPTKSQLELYQSILRKRANQVSSTSLTKSSSPKPLPSSAIVKFDFGNGKSIVHEFSKDDNIETLRAFVASHLSPEESTSFQLTFSNYEALPTTGLIVEHIGRAVVRVHTISDPVYAQR
What is the function of this protein?
Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
What are the official names of this protein?
UBX domain-containing protein 4.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRI38_BOVIN
Sequence: MASKKMREEATCSICLHLMTNAVSISCGHSYCHVCIVSFFENLNRMTPGLKTFSCPQCRAPFTMASLRPNKQLGNLIEVIKEMDQEMSCEEHGEKLHLFCEDEGQLICWLCDRGAQHKGHATALVEEACQGYKEKLQQAVTKLRQLEEECMNLKVFTAEQITKWNEKIEFQKQKIQSDFKTLQRFLHEEEKSYLWKLEKEKEQTLRRLRDNEANLEQKNHELQSHILELENKCQGSAQKLLQDVKDTLSRSWAVKLEQPEALSLDLHTVCNVSELYFDVKKMLRRHQVSVTLDPETAHYELILSEDRRQVIRGCPQENLDNSSRRFSALPCILGYEGFTSGKHYFEVDVGEGTGWDLGVCMENVQRDTVMPQTPQSGFWAIRRCKEGYVALTSPLTSIHLTEKPLVVGIFLDFEAGVVSFYNMTTGSHIFTFPKASFSDTLRPYFQVYLYSPLFLPPPDE
What is the function of this protein?
E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity.  Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation.  Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.  Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity).  Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM38, Tripartite motif-containing protein 38.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_BACP2
Sequence: MEQEWLNVGKIVNTHGVRGEVRVVSKTDFPEERYKKGSVLYIFKQGQGEPLKVTVASHRQHKQFDLLTFEEISSLNEAELLKESILKVEKEHLGSLDEGEFYFHQIIGCEVYDEENQLVGQIKEILTPGANDVWVVGRKGKKDALIPYIPSVVKKIDISSKTIHIEVMEGLIDE
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_ACIB5
Sequence: MSNIRPLHDRVVIRRVEEETKTAGGILLPGSAAEKPSQGEVIAVGNGQITDNGVRALDVKVGDKVLFGTYAGTTVKVNGEELLIMKESDILAVLEG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.