PharMolix/UniProtQA huggingface dataset:
Protein: HELA_LEGPN
Sequence: MLEKIIRFSLKHRWFVLLFTLVIAILGVYNFQRLPIDAVPDITNVQVQINTQASGYSPFEVEQRITFPIELAMSGLPSLDYTRSLSRYGLSQVTVVFKDGTNIYFARQLINERLQEVKDKLPPGVETTLGPISTGLGEIFMYTVTNKPNVPISQHYNPTELRTIQDWIIKPQLRNVEGVAEVNTIGGYEKQFHITPDPSKLVRYRLSLNDVVEALERNNANVGAGYIETNGEQNLIRVPGQVQNMADIENIVIASFEGTPVRIRDVAEVALGKELRTGAATENSKEVVLGTVFILMGENSRTVSERVAAKMKDINKTLPEGVEAITVYNRTTLVNATINTVKNNLLEGALLVCVILFLFLGNIRAALITAMVIPLSMLLTITGMVENQISANLMSLGALDFGLIVDGAVIIVENCIKHLAEQQHALHRVLNLEERLKVISYATTEVIRPSIFGVFIITVVYLPILTLTGVEGKMFLPMAQTVIIALLASMLFALTFVPAAVAIFLRGHLQEKENWLVHYLSLGYAKVLRRCFHARRVVISAAVALVVVSLGIAFHLGGEFIPSLDEGDIAMHAMRIPGTSLTQAITMQDLVEKRIRQFSEVKNVFAKLGTAEVATDPMPPNVADTFIILKSRKKWTNPKKTKPGLVQEIESAVQQIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDMDTLLKTAEAISAQLKQVPGAADVKVEQVSGLPLLTVEINRDVLARYGLQIGTVQEAVVIATGGKKGGELFEGDKRFDIVVRLPESLRSDPNVLRQIFIPLPLSKDGEQHFIPLSEVASLIRSESPNQISRENGKRRVVVTANVRNRDLSSFVSEAKKRIDGQVKLPSGYWITWGGQFEQLQSAYQRLQIVVPITLLGIFLLLFISFGKVRDALLVFTGIPLALTGGVFALWLRGIPLSISAGVGFIALSGVAVLNGLVMITFINKLREQKKVYLKDAVLQGSLARLRPVLMTALVASLGFVPMALATGTGSEVQRPLATVVIGGIISSTFLTLLVLPGLYYVFHGRRKKGQSKSEPQEQIM
What is the function of this protein?
Presumed to function with HelC and HelB in efflux of an unidentified substrate.
What are the official names of this protein?
Protein HelA.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DLHH_ECOLI
Sequence: MATTQQSGFAPAASPLASTIVQTPDDAIVAGFTSIPSQGDNMPAYHARPKQSDGPLPVVIVVQEIFGVHEHIRDICRRLALEGYLAIAPELYFREGDPNDFADIPTLLSGLVAKVPDSQVLADLDHVASWASRNGGDVHRLMITGFCWGGRITWLYAAHNPQLKAAVAWYGKLTGDKSLNSPKQPVDIATDLNAPILGLYGGQDNSIPQESVETMRQALRAANAKAEIIVYPDAGHAFNADYRPSYHAASAEDGWQRMLEWFKQYGGKKSL
What are the official names of this protein?
Putative carboxymethylenebutenolidase, Dienelactone hydrolase, DLH.
What is the protein family that this protein belongs to?
Belongs to the dienelactone hydrolase family.
Protein: YBJQ_SALCH
Sequence: MQFSTTPTLEGQSIVEYCGVVTGEAILGANIFRDFFAGIRDIVGGRSGAYEKELRKAREIAFQELGEQAKALGADAVVGIDIDYETVGKDGSMLMVSVSGTAVKTRR
What are the official names of this protein?
UPF0145 protein YbjQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: TRUD_CAMJJ
Sequence: MNLEEENTIFKPLYSLKHSPINAYFSKNSDDFVVRERPLYEFSGKGEHLILHINKKDLTTNEALKILSETSGVKIRDFGYAGLKDKQGSTFQYLSMPKKFESFLSNFSHPKLKILEIFTHENKLRIGHLKGNTFFIRLKKVLPSDALKLEQALMNLDKQGFTNYFGYQRFGKFGDNYKEGLEILHGKKMKNVKMKEFLISAFQSELFNRYLSKRVELSHFANDFSEKELIQIYKISKEEAKELKKQEQFFKLLKGEVLGHYPFGKCFLCEDLSAELGRFKARDISAMGLLIGAKAYETGEGLALNLENEIFKDTLEFKAKMQGSRRFMWGYLEELKWRYDEEKAHFCIEFFLQKGSYATVVLEEILHKNLFE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: GDE1_SCHPO
Sequence: MLENDLQKVVNLFNTRIVQLDNYVTRLSTEKSPNTEITQALSSSYEAEEKAKQLKELDFRLQQLSSFCEWNKLAFEKLAANMDKHLGTERLVTFYEQKVCKLDFANSSKIYESMIALKALNSSQNDSEVKDKLEKLSIHHPLKKDLLAFIQLDIAAEVVTACINAPDSVLVDILAASIIAGAKACMREVIGRIGLRSECLASALRRAINNLCGPDEGVLYFLEVLKQICSVVYVDSYHSNRLLSRILLVERNSKGQSVMHSVAKLGWAGLCSKFCEIVSSIPDSEPLNWMLPCWRDVMHDTPLTLAIKGNHVEALHALLSAQDKETTSTKPGPVPPLVLTCCVGDYDLIVEELILAGFNPNEVDASSNTALHTAVRYNRPECVKMLLKLGANPSARDFLNSWTPLMLASATGLSEIVSILVASGASVDEVDSSGWTAMEQAVVRGYLHLADKLRTQVALSDKPVNLHTLYIKASSSEMRSRKRAMDLQLSRSVVIIRISDLAGRIRVSLQGDDAVYVSGRSPSFAASRPSSVDFMSQSTDSLSKNDTTASNGSMTPSSSQNNSVIIDIPRSHFDNAGEVCLENLAEPDEIADDSIHLHYDAAQENSPQPVNGSSPPYELVFVTRNTEEATITIDLLANRSHKILGRTVCCLTSLVSDLGNHMQSLKPLAPLPLLSSKTLKPIAHVNADVLISKVTVDDRFSSNDGISTPALSLEAVSNVSRTALEDAERSLHKSATTTSESGKSNGVAVIGHRGLGKNQPDRLSLQLGENTLQSFIKAADLGASYVELDVQMTKDMVPVVYHDFIVNETGTDAQVHSLTLEQFLGASHSPSEEIKDDASDIQQKRRPRAYSSSFTPSGSQVNFGEFAEENARLKPKVYKGNALGHTICAPFTTLKDVLKEVPQSVGLNVEFKYPMLSEAEEEKLLPIAYDYNFYVDTILSIIKKYGGKRKYIFSSFNPDICILLSLKSTNPVLFLTEGGTAYRTDVRAASLRQALKFASQWSFLGIVSACEPLIMCPRLIKAVKQLGLSCYTYGVLNNDVDNVRRQVRFGVDAVIVDNVLAIRRALNQYDESLESD
What is the function of this protein?
Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline.  The choline is used for phosphatidyl-choline synthesis.  Required for utilization of glycerophosphocholine as phosphate source.
What are the official names of this protein?
Glycerophosphocholine phosphodiesterase gde1, Glycerophosphodiester phosphodiesterase gde1.
What is the protein family that this protein belongs to?
Belongs to the GDE1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AHPC_DELAC
Sequence: SVINTQIKPFKTQAFKNGKFIEVTE
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Alkyl hydroperoxide reductase C, Peroxiredoxin, Thioredoxin peroxidase.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMYA_PYRAB
Sequence: MPRINFIFGIHNHQPLGNFGWVMEEAYEKAYRPFLEILEEYPNMKVAIHISGILVEWLEENKPDYIDLLKSLVRKGQVEIVVAGFYEPVLAAIPKEDRLEQIYLLKEWAKKIGYDAKGLWLTERVWQPELVKTLREAGIEYVVVDDYHFMSAGLSKDQLFWPYYTEDGGEVITVFPIDEKLRYLIPFRPVDKVISYLHSLASEDESKVAVFHDDGEKFGIWPMTYEWVYEKGWLREFFDRVSSDEAINIMLYSEYLQKFKPKGLVYLPIASYFEMSEWSLPAQQAKLFVEFVEKLKELNMFERYRVFVRGGIWKNFFYKYPEANYMHKRMLMLSRLLRDNPSARRFVLRAQCNDAYWHGVFGGIYLPHLRRAIWSNLIKAHSHLEPKNKILDVDFDGREEVFLENDNFIIVVKPHYGGSIFELSSKRRAVNYADVIARRWEHYHNLGESESDDNENQEGVSSIHEIGKRIPEDIRKELAYDRYRRGILQDHFFSANETLDRYRLAKYWELGDFIEGVYNYEVGNGLVLWRRGKVLNVTVDVKKSIEVREDGFSVRYTVLSEEDIEALFGIELNIAVHSIKESPEELIGKRIKVNDKYGVGEFEIVLNKKARIWKYPVKTLSQSEAGWDYIQQGVSYTIIYPINGRLDIELYFREL
What are the official names of this protein?
Alpha-amylase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 57 family.
Protein: NFUA_BUCAT
Sequence: MINISKKAQEHFTSLLSNEPENTQIRVFIVNPGTPNAECGVAFCPENEIELSDIQLKYDGFFVYVNKDTISYLKNSVIDLVTDKIGSQLTLKAPYAKNNFSKKVSSSLEEKVKCFLNLEINPQLSMHGGRVELIKIDKNGIAAIQFSGGCNGCSMIGSTLKETVEKKLLSSFSEIKKVYDETHHLHGQHSFY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: CYB_ARTCO
Sequence: MTNIRKTHPLLKIINSSFVDLPAPSSLSTWWNFGSLLGVCLGVQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWLLRYLHANGASMFFICLYLHVGRGLYYGSYMYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVTALVMVHLLFLHETGSNNPTGIPSDPDMIPFHPYYTIKDILGFLIMLTALATLVLFSPDLLGDPDNYIPANPSITPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIVPILHTSKQRSMMFRPLSPCLFWLLVAVLFTLTWIGGQPVEHPYIIIGQTASVLYFLIILLLMPMISMVENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ATPG_BART1
Sequence: MASLKDLRDRIASVKATQKITKAMQMVAAARLHRAQEAAQSARPYAKRMADILTSVAADVDGVDAPALMRGTGRDDVHLLVVCTAERGLCGAFNVQIARRAREQIKALLAAGKIVKIITVGKKGADILSRDYKSLMIDHIDLHAVKRIGFAEALVISQRIVDLFNEGAFDVCTLFYSEFVSVINQRPTAFGLIPMGAPKAAVEATDVVEQKETSKDSQSIVHEAIVYEYEPDAASLLEALVPRNLSVQIFRALLENVAGEMGAKMTAMDNASRNAGEMINKLTVAYNRQRQAQITTELIEIIAGAEAL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YNIU_FRAAL
Sequence: MTATATVIELTDKAVAQVRHLLGSTPGHRGLRLRIGVDPGGCSGYTYKLALVPGAETGDVVLPQDGFDVVVHTTGVDLLRGMRVDYTETLTSSGFTFANPNAKSSCGCGSSFGSSDDPERTAGRREAAANRSRRS
What are the official names of this protein?
Uncharacterized protein in nifB-nifU intergenic region, ORF2.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: NSA1_SCHPO
Sequence: MKLLLGDEIGQLKFIEIKKGTDTSNPESEAPVIQKFGELDREKGVLFMLKHEMNVFVARKNGTIECWNVNQEPPILSSLWQLDSSLLETASIVSMKYSNGWLMLALSDGNLLFRHIESSKLRKLQLHGPLSAVELHPRIPGIIAAGGKENDVCLYSCNPTCKSNIDELELWRTENVVKVFQGKNVKNDSLNLRVRVWITGIVFTEDIINVIDGKSEDDESLCFHFATITHYGQLRFYDTKHGRRPVSTFDVSTSPLSHVGLLPSIKLLYFADKRAQISIFDHSKKKVIGRFQGVKGAPSSIHCLGNVVAITGLDRNVRIFDADRKPLANAYIKALPTSIIVINERDAEIIKKEEELEAAKEEEEEIWRNMEQLEDTEDKKPSKRIKL
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein nsa1.
What is the protein family that this protein belongs to?
Belongs to the NSA1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MCM4_HUMAN
Sequence: MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:16899510, PubMed:25661590, PubMed:9305914).  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425, PubMed:16899510, PubMed:25661590, PubMed:9305914).
What are the official names of this protein?
DNA replication licensing factor MCM4, CDC21 homolog, P1-CDC21.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: PNP_TRIEI
Sequence: MEEIDKSISFDGRDIRLKVGLFAPQAGGAVMIESGDTAVLVTATTAKGREGIDFLPLLVDYEERLYAGGKIPGGFLRREGRPPEKVTLTSRLIDRPLRPLFPSWLRDDIQIVATTLSMDEEVPPDVLAVTGSSVAVLLAKLPFYGPMAAVRVGLVGDDFIINPTYREVKNGDLDLVVAGSPQGVIMVEAGANQLPEQDIIEAIDFGYEAVCDLIQAQREIIAEMGIELVELEPPEVDPTLENYIKEKATEQIKEILSQYDLDKNQRDEKLDEIKDSLAESITELPEEEAVRAMVESESMLLGNAFKSVTKKLMRQQIVAEGIRVDGRKLDEVRPVSCRVGVLPSRVHGSSLFNRGLTQVMSAVTLGTPGDAQELADDLHPQDEKRYLHHYNFPPFSVGETKPLRQPGRREIGHGALAERALIPVIPKSDIFPYVIRVVSEVLSSNGSTSMGSVCASTLGLMDAGVPIVKPVSGAAMGLIKEDEEVRILTDIQGIEDFLGDMDFKVAGTDSGITALQMDMKITGLPIEVIADAIHQAKPARIHILDKMLSVLDLPRPDMSPYAPRLLSFKIDPEMIGLVIGPGGKTIKGITEETGVKIDIDDDGTVTIAAADGEKAKQACNIIQGMTKKLNPGDVYVGRVTRIIPIGAFVEVFAGKEGMVHISQIADYRVGKVEDELAIGDEVIVKVREIDSKGRVNLTRLNIHPDEAAAARANAMNY
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_SYNAS
Sequence: MQVSLRWLKDYVDIDLTPAEVSDRLTMAGLEVDAVREVGPSFSNVVVARIIALRRHPNADKLSLCEVTTGDETLPIVCGAPNIHVGDVVPLARIGAEIPGGYTIKRSKIRGELSEGMLCSEEELGIGEDTTGVMILPPNLPLGEDLADVLDLKDTVFDIGITPNRSDCLSIIGVAREIAAITGKPLKLPEIYVTENAEDIQVSASVQILDPDLCPHYTARMIRDVVVGPSPQWMRLRLEAVGLRSISNVVDVTNFVMMELGQPLHAFDYRFLEEGRIVVRRSTEGEKFISLDEKERVLNANTLMICDGVKPVAIAGIMGGFNSEIKPDTRDILLESAYFAPSSIRRSARDLGMSTDAAFRFERGIDPEGVLRALDRAAQLIAELSGGKICKGRIDEHPKPVETVGEIHLRCRKVNSLLGTNIPAAEMADILRGLGMEVTAKEGTVEEYRIKPPSFRVDIGREIDLVEEIARIHGYDNIPVSLPVGAMEPVPRDRRKILEERLRRHLAGTGFSEVITYSFVSPTAADILALDAGDERRKVVRIKNPLTEDQSVMRTTLIYSLLKVMQENANAGDYDLKIFEIGKIFLQGNTGGLPTEKKRLACLMTGMSDKELWSSGESRLDFYDLKGVVESLFASLNLTGIRYCSDALQAFLHPGRSCGIFIDEKSIGYMGEAHPDVLSRLDMKNRALIFEMDVDAISELFSGSVTYKEFSRYPESSRDVAFVIDQDVEADGMLNIALNAREELLENVCIFDVYAGAGVPEGKKSLGLRFTYRSYSATLTDDEVSRVHSKIVQRIIDQTGARVR
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2P_MOUSE
Sequence: MGKKQKNKSEDSTKDDTDLGALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDENDILRELEELSLEAQGIRADRDAAAVKPTENNEEESASKQDKKKKGQKGKKTSFDENDSEELEDKDSKSKKTARPNSEAPLSGSEDADDSNKLSKKGKKAQKSTKKRDGSEEDEDNSKRSKERSRVNSSGESGGESDEFLQSRKGQKKNQKNKSVPTVDSGNEDDDSSFKIKTVAQKKAEKKEREKKKRDEEKAKLRKMKEKEELEKGKKEQSKQREPQKRPEEEVLTLRGTPDTGAASEEKGDTAAALEDDNEGDKKKKDKKKKKTEKDEKEKEKKKGPSKSTVKAIQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEVTLRHLQAQGVEVPSKDSLPKKRPVYEDKKKKKTPQQLESKEVSETLEISAPVEAVDQGGPEKEETPPSVEPEEEEDTEDAGLDDWEAMASDEEREKEGNMIHIEVEENPEEEEEEEEEEEEEESEDEEEEGDSEGSDGDEEDCKLSDEKDSGKAGDTKPSKDASSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHGKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINILKSKKCPFIVALNKIDRLYDWKKSPDSDVAVTLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKDDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKMKILPQYIFNSRDPIVIGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQLIVELKKVFEII
What is the function of this protein?
Plays a role in translation initiation.  Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon.  GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome.  The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.
What are the official names of this protein?
Eukaryotic translation initiation factor 5B, eIF-5B, Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_STRPF
Sequence: MTENEQIFWNRVLELAQSQLKQATYEFFVHDARLLKVDKHIATIYLDQMKELFWEKNLKDVILTAGFEVYNAQISVDYVFEEDLMIEQNQTKINQKPKQQALNSLPTVTSDLNPKYSFENFIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHLLNAIGNSVLLENPNARIKYITAENFINEFVIHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALHNNNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQDTIEYLAGQFDSNVRDLEGALKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPIEEIQTQVGKFYGVTVKEIKATKRTQNIVLARQVAMFLAREMTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMISQDESLRIEIETIKNKIK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEAH_ECO57
Sequence: MTWFIDRRLNGKNKSMVNRQRFLRRYKAQIKQSISEAINKRSVTDVDSGESVSIPTEDISEPMFHQGRGGLRHRVHPGNDHFVQNDRIERPQGGGGGSGSGQGQASQDGEGQDEFVFQISKDEYLDLLFEDLALPNLKQNQQRQLTEYKTHRAGYTANGVPANISVVRSLQNSLARRTAMTAGKRRELHALEENLAIISNSEPAQLLEEERLRKEIAELRAKIERVPFIDTFDLRYKNYEKRPDPSSQAVMFCLMDVSGSMDQSTKDMAKRFYILLYLFLSRTYKNVEVVYIRHHTQAKEVDEHEFFYSQETGGTIVSSALKLMDEVVKERYNPAQWNIYAAQASDGDNWADDSPLCHEILAKKLLPVVRYYSYIEITRRAHQTLWREYEHLQSTFDNFAMQHIRDQDDIYPVFRELFHKQNATAKD
What are the official names of this protein?
UPF0229 protein YeaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: TOP1_ZYMMO
Sequence: MKLVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDGSVNPDNGFSMVWQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTLSPILWRKLPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLITYMRTDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQVKAKNAQEAHEAIRPTDFSRDKAASGDHARLYELIWKRALASQMASAKLERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRADQHFTQPPPRYSEASLVKKMEDLGIGRPSTYASVIQVLKDRAYVTLERNRFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDSLDEISGGRADWQKVLDAFWHDFKPKTAEVMEQQPSAITAELDKFLEPWLFPDKGDGHDPRECPSCHTGRLALKGGRFGAFIACSNYPECKYTRGFGQGEDGVDDNEPVLLGYMPENSDDDGYMAFSDQGDILPANTASASETGVTDGGIAANAAFSGKGNSASHTDRDDLPFDPDEPASSTGNVASSQSRMTGDETASSGNSRDSSAHGVSTTAGIDAESQAGISNQALAGKNNAGRTAVSDNKGNNSSSTIAAARKGGSTDDNATVSDPDGDIGSGASSSGQDADNRLLSHRNGDIDSRAIPADHKDSSSDQNASHALSPDRNSDDASVSNSDKKIDSKAVSTGHDVGNAITSDNSPSDNVAHLASTPSSATSSVKVALETENNDTAASKADEQAKEEEESRKARAVTRRTGRFGPYIQLGEGKNAKRVSVPRDVNPREVDFSLASRLLALPREIGLHPESGKMIIAGTGRYGPYLNCDGKYARLSSTEELLDIDIDRAVVKLAEAAQNKGRTGATLSREPLKVFGDSPVTEKPVQLMNGRYGPYVTDGETNASLPKDTTPESLTFEEALALLEARAKMPKKKKTKKAAAKKPAAKKTTTKKAAPKKATTKTATPKSATTDNATSEDGDATPAKSPAKKAVAKKTTAKKPASKSATKKAPSSKTTAAKKTSKATPKDEVAE
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: HELB1_ASPFU
Sequence: MRTYAIRPVSNRLPGPIEPKKHRRDRDNSTTGSLYNALIHPVQGEKTITSTMIRVAEFQPFLNTISVLQVLAAIFIGALTYRLIDAFFLSPLRSIPGPLLARLTTKRANVDTFSGKVTQTVDKDVARYGDVYVYKPRAVCINHPDDIRAVLGSQEFRKAAFFDIFNDGNTPNIVSLREPELANRRRRQLGPFFNYAYLGRAEPLILQHGYQAIRTKWDALIQANSGRPTEVNYRTDTQLVTFDIMSALAFGRNFNAISRGSSSIMKWAGLIMEMLESPAVLALLSLLPFSLIMRPWKIMYRELAAFSSDAVDMRKQLLAEDSTEKPLDMLQAFIDAEDPESKIKMSPHEVQAESIMMMLAGSETTSSAIMWTFHLLLLYPETLRRAVHEVRSAFSLNHLVTYKDVRSSLPYVEACVYEALRHSPTTAGLTPRISHSTGITLQGYYIPPGTEIYVNLRSPSMHPSLWDDPARFNPDRFLDSDNNKRLLFTFSYGPRNCLGRNLAWVEMLTIVANVLKDYDIALTEDSLFGPHCTDENGLPVLMPAKCFIASFPAKPERDCRMVITRRMAGVKACAREYSPC
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol)(PubMed:19415934, PubMed:19216560, PubMed:29158519).  The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid (PubMed:19216560).  Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C-16, acyltransferase helD2-dependent acetylation of 16-OH, oxidation of C-21 by cytochrome P450 monooxygenase helB4, and short chain dehydrogenase helC-dependent oxidative decarboxylation yield the fusidane skeleton (PubMed:29158519).  This intermediate is further modified in three additional steps mediated by the cytochrome P450 monooxygenase helB3, the acyltransferase helD1, and the 3-ketosteroid 1-dehydrogenase helE to give helvolic acid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Compared with the late stages in the biosynthesis of helvolic acid, enzymes involved in the early stage modifications act in a relatively strict order (PubMed:29158519).  The hydroxylation of C-16 by helB1 and subsequent acetylation by helD2 should occur before the helB3-mediated oxidation of C-21 (PubMed:29158519).  C-4 demethylation in fusidane-type antibiotics proceeds in an unusual manner though it is also achieved by oxidative decarboxylation (PubMed:19415934, PubMed:29158519).  The methyl group at C-4 beta position is oxidized by helB1 and subsequently removed by the short chain dehydrogenase helC (PubMed:19415934, PubMed:29158519).
What are the official names of this protein?
Cytochrome P450 monooxygenase helB1, Helvolic acid biosynthesis cluster protein B1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.