PharMolix/UniProtQA huggingface dataset:
Protein: LPXH_HISS2
Sequence: MKKTFFIADLHLSENRPHLTELFVHFMQTQAPQAEKLYILGDLFDFWIGDDEQSALIETVQQQILQLTQKGISCYFIHGNRDFLVGRQFANSCGMELLPTYQIVNLYGKKVLICHGDTLCTDDLAYQQYRKKVQQKWLQWLFLHLPLKVRLKIAEKIRQKSKTDKTHKSIEIMDVNKDFVEQIMQQFQVNILIHGHTHKQNIHQNPPHFTRIVLGDWGATASVLEVSANGFQFI
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SRY_HUMAN
Sequence: MQSYASAMLSVFNSDDYSPAVQENIPALRRSSSFLCTESCNSKYQCETGENSKGNVQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQLGHLPPINAASSPQQRDRYSHWTKL
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development (PubMed:11563911).  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:16996051, PubMed:16414182).  Involved in different aspects of gene regulation including promoter activation or repression (PubMed:9525897).  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (PubMed:1425584, PubMed:8265659, PubMed:8159753, PubMed:11563911, PubMed:15170344).  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (PubMed:1425584, PubMed:8265659, PubMed:8159753, PubMed:11563911, PubMed:15170344, PubMed:16762365).  Also involved in pre-mRNA splicing (PubMed:11818535).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (PubMed:15297880). Colocalizes with SOX6 in speckles (PubMed:11818535). Colocalizes with CAML in the nucleus (PubMed:15746192). Colocalizes in the nucleus with ZNF208 isoform KRAB- O and tyrosine hydroxylase (TH) (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (PubMed:19349578).
Protein: PEPB_PHOLL
Sequence: MTKQIMPITLSYEPAAACWGEKALISSSEQGVMVHLVGKGKLGAVQRAGRKIDGQGIRHVALVGEGWDLEKSWAFWQGFRAPKGNRSIEWPQLPAAEKQELESRIKIIDWVRDTINMSAEELGPEQLAKRAIDLMCGMACESVSYRIIKGEDLREQGYTGIHTVGRGSSRDPILLALDYNPTGNPQAPVFACLVGKGVTFDTGGYSLKQSSFMDSMKSDMGGAATLTGALALAISRGLKQRVKLFLCIADNMVSGNAFKLGDVIHYRNGKSVEVMNTDAEGRLVLADGLIDASKEKAKLIIDAATLTGAAKTAVGNDYHSVLSFDDKLADDLLTAAASENELFWRLPLAEFHRSQLPSNFADLNNVAASPHTAGASTAAAFLSHFVEEYQKGWIHIDCSATYRKSAVEHWSAGATGYGVRSIANLLLAKAK
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BLMH_HUMAN
Sequence: MSSSGLNSEKVAALIQKLNSDPQFVLAQNVGTTHDLLDICLKRATVQRAQHVFQHAVPQEGKPITNQKSSGRCWIFSCLNVMRLPFMKKLNIEEFEFSQSYLFFWDKVERCYFFLSAFVDTAQRKEPEDGRLVQFLLMNPANDGGQWDMLVNIVEKYGVIPKKCFPESYTTEATRRMNDILNHKMREFCIRLRNLVHSGATKGEISATQDVMMEEIFRVVCICLGNPPETFTWEYRDKDKNYQKIGPITPLEFYREHVKPLFNMEDKICLVNDPRPQHKYNKLYTVEYLSNMVGGRKTLYNNQPIDFLKKMVAASIKDGEAVWFGCDVGKHFNSKLGLSDMNLYDHELVFGVSLKNMNKAERLTFGESLMTHAMTFTAVSEKDDQDGAFTKWRVENSWGEDHGHKGYLCMTDEWFSEYVYEVVVDRKHVPEEVLAVLEQEPIILPAWDPMGALAE
What is the function of this protein?
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
What are the official names of this protein?
Bleomycin hydrolase, BH, BLM hydrolase, BMH.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic granule. Note=Co-localizes with NUDT12 in the cytoplasmic granules.
Protein: PCKA_STAA9
Sequence: MSVDTYTETTKIDKLLKKPTSHFQLSTTQLYNKILDNNEGVLTELGAVNASTGKYTGRSPKDKFFVSEPSYRDNIDWGEINQPIDEETFLKLYHKVLDYLDKKDELYVFKGYAGSDKDTMLKLTVINELAWHNLFAKNMFIRPESKEEATKIKPNFTIVSAPHFKADPEVDGTKSETFVIISFKHKVILIGGTEYAGEMKKGIFSVMNYLLPMQDIMSMHCSANVGEKGDVALFFGLSGTGKTTLSADPHRKLIGDDEHGWNKNGVFNIEGGCYAKAINLSKEKEPQIFDAIKYGAILENTVVAEDGSVDFEDNRYTENTRAAYPINHIDNIVVPSKAAHPNTIIFLTADAFGVIPPISKLNKDQAMYHFLSGFTSKLAGTERGVTEPEPSFSTCFGAPFFPLHPTVYADLLGELIDLHDVDVYLVNTGWTGGKYGVGRRISLHYTRQMVNQAISGKLKNAEYTKDSTFGLSIPVEIEDVPKTILNPINAWSDKEKYKAQAEDLIQRFEKNFEKFGEKVEHIAEKGSFNK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLK_ECOLI
Sequence: MTKYALVGDVGGTNARLALCDIASGEISQAKTYSGLDYPSLEAVIRVYLEEHKVEVKDGCIAIACPITGDWVAMTNHTWAFSIAEMKKNLGFSHLEIINDFTAVSMAIPMLKKEHLIQFGGAEPVEGKPIAVYGAGTGLGVAHLVHVDKRWVSLPGEGGHVDFAPNSEEEAIILEILRAEIGHVSAERVLSGPGLVNLYRAIVKADNRLPENLKPKDITERALADSCTDCRRALSLFCVIMGRFGGNLALNLGTFGGVFIAGGIVPRFLEFFKASGFRAAFEDKGRFKEYVHDIPVYLIVHDNPGLLGSGAHLRQTLGHIL
What is the function of this protein?
An ATP-dependent kinase that phosphorylates glucose to make glucose-6-phosphate, not active on fructose, galactose or mannose.  Not highly important in wild-type E. coli as glucose is transported into the cell by the PTS system as glucose 6-phosphate.
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_NITWN
Sequence: MINSRQTLDLKLFAASPGEPVDWRRSDQPVPYPGAVDAMERRAAAIASSEAAEQVWLLEHPPLYTCGTSGREADLVKARFPLFSTGRGGQITYHGPGQRIAYVMLDLKRRRPDVREFIACLEEWIIRTLDAFGVKGERREDRVGVWVARPDKGPGHEDKIAAIGVRLRRWVSFHGVSLNVDPDLSHFADIVPCGVSDPRYGVTSLADLGLRVRLTDIDQALKRTFSEVFGS
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_BRASO
Sequence: MSPTPSSGPVIAPAPKGILDPATGRPVGAHDPYFLEVKHELSDKGFFVATADDLITWARTGSLMWMTFGLACCAVEMMQVSMPRYDVERFGFAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPIDIYVPGCPPTAEALLYGVLLLQKKIRRTGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NPT2A_SHEEP
Sequence: MISYGENLGGRAVSPLPVRGGHMMHGAAFAYVPSPQVLHRIPGTSAYGFPSVGPMALPEHGCPYGEVVEHHDPLPAKLALEDERKPEPGLIQKLRRAGVTLLKVPLMLSFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIVVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIRGGRDAPDLLKIITEPFTKLIIQLDKSVITSLASGDESLRNHSLIRVWCYPNPTEVPTPMPRAEANTSRMLRNATLEKCNHIFVDTGLPDLAVGLILLAGSLALLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPTPFTWATGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFFNISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLLCFLLLPSMVFGLSMAGWRAMVGVGAPFGALLAFVVLVSALQHRSPGCLPKWLQTWDFLPLWVHSLKPLDHLITRATLCCARPEPRSPPLPTRVFLEELPPATPSPRLAMPHHHDATRL
What is the function of this protein?
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane.  The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic.
What are the official names of this protein?
Sodium-dependent phosphate transport protein 2A, Sodium-phosphate transport protein 2A, Na(+)-dependent phosphate cotransporter 2A, Sodium/phosphate cotransporter 2A, Na(+)/Pi cotransporter 2A, NaPi-2a, Solute carrier family 34 member 1.
What is the protein family that this protein belongs to?
Belongs to the SLC34A transporter family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules.
Protein: GL8D1_RAT
Sequence: MSFRKVTIIIWALAVILFLLALHHNFLSLSSLLRNDVSDSGIVGLQPIDFTANFHQHPVNERQEEIPVVIAASEDRLGGTIAAINSIHQNTRSNVIFYIVTFNRTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKEDPDQGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSASTKVMIRGAGNQYNYIGYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRAASYADVWEKWYIPDPTGKFSLIRRHMDTSNIK
What are the official names of this protein?
Glycosyltransferase 8 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: DERL1_MOUSE
Sequence: MSDIGDWFRSIPAITRYWFAATVAVPLIGKLGIISPAYFFLWPEAFLYRFQIWRPFTATFYFPVGPGTGFLYLVNLYFLYQYSTRLEAGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDLIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ
What is the function of this protein?
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins.  Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane.  This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome.  The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first.  May mediate the interaction between VCP and the misfolded protein.  Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.  By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.
What are the official names of this protein?
Derlin-1, Degradation in endoplasmic reticulum protein 1, Der1-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the derlin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LPXC_LEPBL
Sequence: MKEILYRKSIQDRVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEYRKGLEKASISVELSNVVDTSNATTLGDGLHKIQTVEHLLAAIYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIVKYPEIIEPIYVQNPLWVVDGDKYLVLLPSDELKVTYTIDFNHPLLKGQNITISLDKETIKQEILPARTFGFLKDVEALQAKGLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKILDLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSSVTGDEISKYKSRRIPLFKRKVAVV
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: CC85B_HUMAN
Sequence: MEAEAGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFLDSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEWGPRGGPSGAGGSGAGPAPELALPPCGPRDLGDGSSSTGSVGSPDQLPLACSPDD
What is the function of this protein?
(Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication.
What are the official names of this protein?
Coiled-coil domain-containing protein 85B, Hepatitis delta antigen-interacting protein A, Delta-interacting protein A.
What is the protein family that this protein belongs to?
Belongs to the CCDC85 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, adherens junction.
Protein: Y350_METKA
Sequence: MLHDPNDDPSEYVIYVIDRGSSSGLRRIWGDEIQDVKRGFLVLWNAEIPVHRVIRVERGGRVIWERGRRARGRR
What are the official names of this protein?
UPF0248 protein MK0350.
What is the protein family that this protein belongs to?
Belongs to the UPF0248 family.
Protein: PMTB_ARATH
Sequence: MKPLTNGDLFKSPTLIKISALVFVTVAFFYLGKHWSDDGYQQLVFFSSSTSGSSIPEVSVSPNSNRVFNLSAIIPTNHTQIEIPATIRQQPPSVVADTEKVKVEANPPPPPPPSPSPPPPPGPVKSFGIVDANGVMSDDFEVGEVESDTVEDWGNQTEIVEAKSDGDSKARVRIKKFGMCPESMREYIPCLDNTDVIKKLKSTERGERFERHCPEKGKGLNCLVPPPKGYRQPIPWPKSRDEVWFSNVPHTRLVEDKGGQNWISRDKNKFKFPGGGTQFIHGADQYLDQMSKMVSDITFGKHIRVAMDVGCGVASFGAYLLSRDVMTMSVAPKDVHENQIQFALERGVPAMAAAFATRRLLYPSQAFDLIHCSRCRINWTRDDGILLLEINRMLRAGGYFAWAAQPVYKHEPALEEQWTEMLNLTISLCWKLVKKEGYVAIWQKPFNNDCYLSREAGTKPPLCDESDDPDNVWYTNLKPCISRIPEKGYGGNVPLWPARLHTPPDRLQTIKFDSYIARKELFKAESKYWNEIIGGYVRALKWKKMKLRNVLDMRAGFGGFAAALNDHKLDCWVLSVVPVSGPNTLPVIYDRGLLGVMHDWCEPFDTYPRTYDFLHASGLFSIERKRCEMSTILLEMDRILRPGGRAYIRDSIDVMDEIQEITKAMGWHTSLRDTSEGPHASYRILTCEKRLLRA
What are the official names of this protein?
Probable methyltransferase PMT11.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: METN_LACAC
Sequence: MSIIELKNVDVDFPQKKGKLVKAVNSVSLSIEKGDIYGIVGFSGAGKSTLVRTINLLQKPSAGDIEVDGTQFVKDGKQVISNKELQLKRRNIGMIFQGFNLLNETTVLENVAFALKHEKLSDDELEKKSLELLELVDLKEKANFYPSELSGGQKQRVAIARALANNPDILISDEATSALDPQNTQQILDLLKRLNKQFNLTVILITHEMDAVKKIATKVAVMEHGQVIEKGSLRQVFLHPKQELTKKFVGGSLEAISTLNSLHLDKLSKNESIYQLVYSVNNVAKSIIIELYKEIGVEVSMLYGNVELLNDEPIGTLVVLIKGDQEKQKQAKEFLQKQDVTLTRLDEKGNIYD
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ECFA2_STAEQ
Sequence: MSIQFNQVSYIYQQGTPYEFEAIKNVSLTLEQGKYYAIIGQTGSGKSTLIQHLNALLKPTTGSVNINGLEVTNKTKDKHLRHIRKEVGIVFQFPESQLFEDSVEKEIEFGPKNFNMNLKNVKDKAFQLLLELGFSRNVMSSSPFQMSGGQMRKIAIVSILAMDPQVIILDEPTAGLDPNSKHQVMSLIKKIQIEENKTIILVSHDMDDVARYSDEVVVMNKGTIVEKSNPRNLFNQKTQLLKWHIELPKVVKLQKDIEKKYNMLFPKLAMNEEEFVKLYKEWHHEE
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS18_PARD8
Sequence: MAATQSEIRYLTPPSVDVKKKKYCRFKKNGIKYIDYKDPEFLKKFLNEQGKILPRRITGTSLKFQRRVAQAVKRARHLALLPYVTDLMK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RL21_POLNA
Sequence: MYAVIKTGGKQYKVAAGEKIKVEQIAADVGQEIVIDQVLAVGEGSSIKVGTPLVSGATVTVTVLSHGRHDKVRIFKMRRRKHYQKRQGHRQNFTELQIGAIVG
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: TYSY_PHOLL
Sequence: MKQYLDLMTRVLAEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHIRSIIHELLWFLNGDTNIKYLHENGVTIWDEWADENGDLGPVYGKQWRAWGTADGRQIDQLKTVLEQLKSDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMEQTKLQLSREPRSLPKLVIKRKPASLFDYKFDDFEIVDYDPHPGIKAPVAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_XANOP
Sequence: MYSLARPLLFSLDAERAHALALRSIDTAYRTGTTSLLSTRPVPLPTPAFGLMFPNPVGLGAGLDKNGEHIDALLALGFGFVEIGTVTPRAQDGNPKPRMFRLPEYQAVINRMGFNNLGVDALVANVQRARRRGGLLGINIGKNKDTPNEEATSDYRYCMERVYPLADYITVNISSPNTAGLRELQEEQSLRRLISDLRETQEALGAQHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVDGVIATNTTVTRPLIANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINSGADAVAKMAAGASLVQCYSGLVYRGPQLVGECVNAIRRRREAPSSGAVAPL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CX67_CONAA
Sequence: WRKTPEGADRTFLQQECYQEIRQKRCRTVGRPCHYSAQCCSDFCAHTISNYYYIKRCS
What is the function of this protein?
Probable toxin that inhibits ion channels.
What are the official names of this protein?
Conotoxin Am6.7.
What are the subcellular locations of this protein?
Secreted.
Protein: RF3_NOSP7
Sequence: MSTELQSELIQAVELRRNFAIISHPDAGKTTLTEKLLLYGGAIHEAGAVKARRAQRKATSDWMAMEQQRGISITSTVLQFEYQKCQINLLDTPGHQDFSEDTYRTLAAADNAVMLIDAAKGLEPQTRKLFEVCKLRGIPIFTFINKLDRPGREPLELLDEIEQELGLQTYAVNWPIGMGDRFKGVFDRHKQQIHLFERSAHGSREARDTIVELGDPRIEEKLEQSLYYQLKNDLELLEGVGPELDLQLVHEGKMTPVFFGSAMTNFGVELFLKYFLEYALKPGSHYSSVGEVAPTYPEFSGFVFKLQANMDPKHRDRVAFIRVCTGKFEKDMMVNHARIGKLIRLSRPQKLFAQERESIDVAYPGDVIGLNNPGVFAIGDTIYTGQKLEYEGIPYFSPELFASLRNPNPSKSKQFQKGVAELREEGAVQIMYSTDEAKRDPILAAVGQLQFEVVQFRLQNEYGVETILDLLPYSVARWVEGGWEALEKVGRIFNTTTVKDSMGRPVLLFRNEWNCQQLLGDHPELKLSAIAPVFSSQQPVEE
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAM4_YEAST
Sequence: MARLPLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIPFISESFWSDESSANRKIVKEMFNDFLNAGAEILMTTTYQTSYKSVSENTPIRTLSEYNNLLNRIVDFSRNCIGEDKYLIGCIGPWGAHICREFTGDYGAEPENIDFYQYFKPQLENFNKNDKLDLIGFETIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGDKINPNFSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWDTVVKQYISSGARIIGGCCRTSPKDIQEISAAVKKYT
What is the function of this protein?
Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio.  Converts also S-methylmethionine (SMM) to methionine.
What are the official names of this protein?
Homocysteine S-methyltransferase 2, S-adenosylmethionine metabolism protein 4, S-methylmethionine:homocysteine methyltransferase 2, SMM:Hcy S-methyltransferase 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PUM1_CHICK
Sequence: MSVACVLKRKAVLWQDSFSPHLKQHAQDTANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWESDDSSKDGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQGFHVNSEVNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGFGPRDAENDENDKGDKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDTDVKDFSRTPGNCQNSASEVDLLGPNQNGSEGLAQLASTNGAKPVEDFSNIESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIAGLAPAAFVPNPYIISAAPPGTDPYAAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSANQQTTQQTQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPTNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLGFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFPSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPPDQQVINEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAMLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPAQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII
What is the function of this protein?
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets.  Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE).  Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation.  Also mediates deadenylation-independent repression by promoting accessibility of miRNAs.
What are the official names of this protein?
Pumilio homolog 1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule.