PharMolix/UniProtQA huggingface dataset:
Protein: INT10_DICDI
Sequence: MMVDNEEINSLSIENILERINKSSNINEAKSLCLFASSLFDNNQYLLIQRYLISIKERDFDISIQLFWRLFNNNSFKEYIVLVVLKFLEKEIEDLEYYDFIKKNYRDQFQKIFIDSDDNSTNNSSSSSNENKKNKRSYLKLNTILNKLTKSLNHLSFYISEIDNLNKFFNPITFLLNNNNNNNNNNNNNNNNNNNKNNSNNNNKNNNNNNDDSNNNNNNNFLKILELIQKSCQYLNENENYEYSILLYLLIKGKFENKIRTFIKSSKKEDQDIKSKIKRFWFNGIQSLNQYKNKYSSKIEIEPPLPMKSYFDEDDYDQKQQQQQQQQQQQQEQKGSKEDEEDIEKQKKSLTSEIELFLLPINRFCLPIIFHIENEEFEQLDIKGNSGSGSDSSSSISKLEIVDQCWKYYICKGDDITDESILEIQKFLQQFADSGKHLKRHQNNSILNFTINLLSNPEKARNDYFDRNSEGNGGDENDENSQESNDSYEFEIHLGIYLLSSLLYISSWRYFKFLVTGSSNIEKQNIQTIGTLKKNQILLFDANFNSNSNSSSGSNGIINNNSNSNQQSYHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNQGQQPNLSMITHQVLYYSNVDDESSFDDEFPKIVFTKQQTEAIKHLTLCMECFNDLNQEPWINDFKRILSTTWNNSKFYWLYNSLADSHYYYKLDGANTLIPIGDSKKRLFNPNDELWFNRLLLNIGMTNHSEIEDSIICLLEILISISIPPPPSSSSSSFSSSNSSLNNDLFNQQLVPSKHTFKTIKPYLTVFSEEEILFWCIDTLATCYERLGMVGEITVLYQAYWNYYKSRFYQIINEIKGTPNQNPNLIPLSNLVKKDLQIGYFFPRFFDYIINIEMLEEFCFILNKGFKLDILQRNQTVSSNREMIDIIKRHITITTSNNNLTIPILLKQFFNEELDHFLIKKENREKQYSSSNTANNSGVNNSPIHNQNTDVEMNE
What is the function of this protein?
May be a component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
What are the official names of this protein?
Integrator complex subunit 10-like protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: ST1A1_MACFA
Sequence: MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFRARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCRRAPIFMRVPFLEFKVPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSHTHPVLYLFYEDMKENPKREIWKILEFVGRSLPEETVDLMVQHTSFKEMKKNPMANYTTIPQELMDHSISPFMRKGMTGDWKTTFTVAQNEHFDVDYAEKMAGCSLSFRSEL
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe.  Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites.  Displays broad substrate specificity for small phenolic compounds.  Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (By similarity).  Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity).  Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity).  May play a role in gut microbiota-host metabolic interaction.  O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria.  The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
What are the official names of this protein?
Sulfotransferase 1A1, ST1A1, Aryl sulfotransferase, Phenol sulfotransferase, Phenol-sulfating phenol sulfotransferase, P-PST.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IGHD_RAT
Sequence: KDEYITILQVSVPAPNLSPNLTCTITNTSKKKSKTFKLPETRNSQSSKKANPTPQAKNHYIEATKPTATKNIVGAMAPSNLNVNILTTFTHHQMSSWLMCEVSGFYPEDIHLWWLSAQTKMDPINFVTAQPVRQSGDKFQIWSVLRLPVALSPSLDTYTCVVEHEASQTKLNASKSLEISGCYHLLPESDGPPRRPDGPAFP
What are the official names of this protein?
Ig delta chain C region.
Protein: TRUB_PSEPF
Sequence: MAQVKRIRRNVSGIILLDKPLGFTSNAALQKVRWLLNAEKAGHTGSLDPLATGVLPLCFGEATKFSQYLLDSDKGYETLAQLGKTTTTADAEGEVLQERPVTVGQADIEAVLPKFRGQISQIPPMYSALKRDGQPLYKLARAGEVVEREPRSVTIARLELLAFEGDTARLAVDCSKGTYIRTLVEDIGEQLGCGAYVAELRRTQAGPFTLAQTVTLEELEAVHAEGGNEAVDRFLMPSDSGLQDWPLLQFSEASAFYWLNGQPVRAPDAPKFGMVRVQDHNGRFIGIGEVSEDGRIAPRRLIRSE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: YKR18_YEAS7
Sequence: MFKVFGFGAKEEIPELSQEEKTKAILKQAHDFEQALRAMDYVLDDNADEGLALLDESDAKEASDQTINALARGVIEFLEATLGFEAEEMKKASATLAKAEALSLKSRERAQKIGLKSSSLYPPGTVYAVTYTESCLLHALLMIFSESMMEAAKAILKLRKSYYMLQEILETIKAANKAKKLKITSGSEDKESTPATFITGGDAFNSVDIPYELTPEEQKDKDLLQFAEQIHSMRTKRLSGAHIGNSPAINRLRGELGLQAMEDLPEEEITDHKVLSDDIDLSQATIDEFVHSGVNLCFGILQVVISLLPPAIGAVLSVVGFRGSREEGLRLVWKATKQRNVHGCIGLLALMFYYDGPFQFTDDDFDIPAAVKDSSNSEDSEDEEMDGPTLLHPGKILEDALLQSRALFPNSALWLLNEARMLSGKGRLEEAVALMDSIDVSKIRMRQVKSLMIFDRAITLIHLHQYDRAAEDILSLLDISDWSHAFYTYFAGCCYLENWRMCEMGLMKSDKKDEYQKKAEELIFTSVNLLGKKTFKSKNLPLDRFILRKVEQFKAKKEELGVENPLDGIATSPVHEISYFYNGYNRMSEEHLELTKKMLTEYRNPAIEALDSDQELIKDLLVSLTLRRLGHIQEGCDILDEKVLPKFFSIQNGKVKYIKKTEDPWAYPTALYERALFTWKLEGMDGLPESKEWLLRAQGYADDYELSTRVGMKIKAAIDRVDHSL
What is the function of this protein?
May be involved in mitochondrial DNA stability.
What are the official names of this protein?
IML2-like protein SCY_3392, YKR018C homolog.
What is the protein family that this protein belongs to?
Belongs to the IML2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: M7H1_BOMMX
Sequence: MNFKYIVAVSFLIASAYARSEENDEQSLSQRDVLEEESLREIRGIGAKILGGVKTALKGALKELASTYVNGKRTAEDHEVMKRLEAVMRDLDSLDYPEEAAERETRGFNQEEIANLFTKKEKRILGPVISTIGGVLGGLLKNLG
What is the function of this protein?
Maximin-H1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria.  It shows also antimicrobial activity against the fungus C. albicans.  Shows strong hemolytic activity.
What are the official names of this protein?
Maximins 7/H1.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYB_FUKAM
Sequence: MTNIRKSHPLMKIINHSFIDLPTPSNISSWWNFGSLLGICLIPQIVTGLFLAMHYTADTTTAFSSVAHICRDVNYGWLIRYTHANGASMFFICLYVHVGRGIYYGSYMFTETWNMGIILLFSVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTSLVEWIWGGFSVDKATLTRFFAFHFILPFIITALTVVHLLFLHETGSNNPSGIDSDSDKIPFHPYYSIKDFMGFLFVFVILLALVLFSPDLLGDPDNYTPANPLNTPPHIKPECYFLFAYAILRSIPNKLGGVLALVLSIVILIIMPLLHTSKQRSMMFRPMSQCLFWILVANLLTLTWIGSQPVEYPYILIGQLSSMLYFTIILILMPLVSMMENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RDRP_CMVIX
Sequence: MAFPAPAFSLANLLNGTYGVDTPEEVERVRSEQREEAAAACRNYKPLPAVDVGASVTEDAHSLRTPDGAPSEEVSVEFVTYGAEDYLEKSDDELFVAFETMVKPMCIGQLWCPAFNKCSFISSIAMARALLLVPNTPNRTMKCFEDLVAAIYTKSDFYYDDECEADDVQINISSRDVPGYSFEPWSRTSGFEPPPICEACNMIMYQCPCFDFNALKKSCAERTFADDYVIEGLDGVVDNATLLSNLGPFLVPVKCQYKQYPTPTVAIPPSLNRATDRVDINLVQSICDSTLPTHSNYDDSFHQVFVESADYSIDLDHVRLRQSDLIAKIPDSGHMIPVLNTGSGHKRVGTTKEVLTAIKKRNADVPELGDSVNLPRLSKAVAERFFIAYINGNSLATSNFVNVVSNFHDYMEKWKSSGLSYDDLPDLHAENLQFYDHMIKSDVKPVVSDTLNIDRPVPATITYHKKGITSQFSPLFTALFERFQRCLRERVILPVGKISSLEMSGFDVKNKYCLEIDLSKFDKSQGEFHLMIQEHILNGLGCPAPITKWWCDFHRFSYIRDRRAGVGMPISFQRRTGDAFTYFGNTIVTMAEFAWCYDTDQFEKLLFPGDDSLGFSVLPPVGDPSKFTTLFNMEAKVMEPAVPYICSKFLLSDEFGNTFSVPDPLREVQRLGTKKIPYSDNDEFLFAHFMSFVDRLKFLDRMTQSCIDQLSLFFELKYRKSGAEAALMLGAFKKYTANFQSYKELYYSDRRQCELINSFSCVELRIERSSFIKQRKKKDGIERRRNDKRRTPTSPHGGGEETETKVSQEESTGTMLQKSQRESAFKSQTIPFPTVLSSRRFGIDRDVPPRECGGIVRV
What is the function of this protein?
RNA-dependent RNA polymerase which replicates the viral genome composed of 3 RNA segments, RNA1, RNA2 and RNA3.
What are the official names of this protein?
RNA-directed RNA polymerase 2a, protein 2a.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: NARH_BACSU
Sequence: MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNVETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEPWNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQKMEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWRYCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADKVEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDWKIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQLLTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAKYDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF
What is the function of this protein?
The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers.  Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit.
What are the official names of this protein?
Nitrate reductase beta chain.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PGAP2_DROME
Sequence: MLPTYERFSDPKSVLFRLPFARLALVALSLPLGGFFFCVIWSLTFDFVRSTYTHCDVTNYLPSVSAAIGNYEPQKTVWRLAIFLHLPLRLAVAKIYLEHYREHIRRSRRLLGILACFLNVVEDLALFCLSFWTSADHYETHRNAFVVFIACSECYMLVSYLLNRNIQKTVLLPHEEKSLRYKRNLFLVNVIAFGLAGYCFVRHNSHCEAGVYTFFALFEYIVVLTNMGFHMTSYWDFYALNVVCDAKHGLYLSQS
What is the function of this protein?
Involved in the lipid remodeling steps of GPI-anchor maturation.  Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).
What are the official names of this protein?
Post-GPI attachment to proteins factor 2.
What is the protein family that this protein belongs to?
Belongs to the PGAP2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NPSR1_MOUSE
Sequence: MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALVAEEWGSFYSSFKTEQLITLWVLFVVTIVGNSVVLFSTCRRKRKSRMTFFVTQLAITDSFTGLINILTDIIWRFTGDFMAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLAIISVIYGLVIRTIWMKSKTHETVISNCSDGKLCCSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFNVLPDTKERFYASVIIQNLPALNSAINPLIYCIFSSSICSPCKMQRSQDSRMTYRERSERHEMQILSKPEFI
What is the function of this protein?
G-protein coupled receptor for neuropeptide S (NPS).  Promotes mobilization of intracellular Ca(2+) stores.  Inhibits cell growth in response to NPS binding.  Involved in pathogenesis of asthma and other IgE-mediated diseases.
What are the official names of this protein?
Neuropeptide S receptor, G-protein coupled receptor 154, G-protein coupled receptor PGR14.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MFS4B_XENLA
Sequence: MAIAVLGPTFLDLAENVESSVANISFIFVGRSMGYLGGSVLGGILFEQINQHLLLGISMLATAAGLFVVPWCKKAVLLTAVMSVVGMSMGFLDTGGNIIILNTWEDQAGPHIQALHFSFALGAFVAPILAKLALEFLPLDKKSFNVSEPFLEQSALPFGIKKSMLSYIVIGTYILLVSLFLFILFSKSRPRQSSGKASDDKFRTARYHNAVIFLLFLFFFCYVGAEVAYGSYIFTYAITYITNIENNYAAGLNSLFWGVFAAVRGLAICFATCLYPGTMLLLSVIGCTLSSLILVLFSRNHLLLWVGTAVYGASMATTFPSGFSWVQQYTTIGGKSASLFVVGAALGEMAIPASVGYLQGMFPNFPVLMYTALASSTMTAILFPVMYKLATAQQDQAQYNRVESDDRRALLSSSGMEEEDEDEAQNWNEADFETIEMNDQMKNSVTVISEDTPGNSAPSEILKHSTKSNGAEAAANKSPSRKHNTDREKND
What is the function of this protein?
May function as a sodium-dependent glucose transporter.  Potential channels for urea in the inner medulla of kidney.
What are the official names of this protein?
Sodium-dependent glucose transporter 1, Major facilitator superfamily domain-containing protein 4B.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: FLGH_ANASK
Sequence: MNPLTRVALAVAAFAALVLALSACGPAHVAGHVPKRRDYAVPDAAGQEAQAASAGSTWREGRAASMLYTDARALRVNDLVVVRIEEIADAKRSADTDLTRRSELNASIEAFLTSLDAPYALKGGATTGFKGLGSTARTERLTATVPAVVRKVLPNGNLFIEGHRVVLVNAEEQHFYISGVVRPIDIDQENGVKSSMVADAEIEFTGRGVLSDNQRQGWLSRLLGWFWPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: CYC_ULVIN
Sequence: STFABAPPGBPAKGAKIFKAKCAZCHTVBAGAGHKQGPNLNGAFGRTSGTAAGFSYSAABKBKTADWBZBTLYDYLLNPKKYIPGTKMVFAGLKKPZBRADLIAFLKDATA
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: CCTP_TALIS
Sequence: MASQSAHLVKTHQLWELLRHRTKTGSYELDGDSLHIADVVATAQQTSTPRLSEDPKVIKGLQDSVDVLFDHLAKGWYVYGVNTGFGGSADSRTTEVIELQKALMQLTQTGILTTPSDGSAIPGHSTPFEWVRAAMVVRCNASLRGHSAVSLPIIKAIINLLVHGLTPVVPLRGTVSASGDLMPLAYVTGSIEGNPDTLLEKNGKVLPSPKALQEAGLAPVFLGPKEGLGLINGTASSAGLGALVVAQAHSLAFLTQVLTGGAVEALRGSSESFHPFIARARPHPGQIECARNIAYFLRGSHLSRDVLAPKDRRREDLAQDRYSLRSAPQWIGPQLEDLLLADQQISIELNSSCDNPLVDSETNDIYYGCNFQAAAVTSAMEKVRLAMQMFGRMLFAQSTEMIDVHLSGGLPANLAADNPSISFTMKGVDINMAAYMAELSYLANPMSSHVQAAEMHNQSVNSMAFASARISHDAIDVLTKMCACSVFTVCQALDLRALHMAFIADATKALASTIELKFSAKVEAGQLNSLQMLIQAHVTRAWGLTGKLDLHARCESLIDSALPIVLCHVAGDVADIIEWKTQAIEVVWNVWTNTFASFSAAPHTSQLLGAGSRLLYNFVRKTLGVPFHEGFVEHPTADSQTLHSRPKKTIDILANLSDSSNSKRDIERERLKGEKPTRSILITMEGKTSRYQDEAHDSAGSFNEETEGLMSGLHRSTKKRKLSSIVKLATPFLIVSFILNIVQLAYITVRRPECYSLYAKLKEHEITVPFRYATEYSDDEHTHEEKDALWNAIDISEGFVAISNDESDRLGLPRSKTFPWDANKGIYVSHGHHALHCTVLLHAYTYDAHQGKKPLVSYHHIEHCLDLLRQDIMCYANDVMDYTPDHGDNFLTGEGQQRKCRDWNKLSAWVKERSACYKTINITRAGEDHGVAHQLDRYTYCPPGSPYEPLIKAFKDLGRVNTGNLAADGFHELTPEELAAEAQAVAEHNKQILADEG
What is the function of this protein?
Phenylalanine aminomutase; part of the gene cluster that mediates the biosynthesis of the mycotoxin cyclochlorotine, a hepatotoxic and carcinogenic cyclic chlorinated pentapeptide (PubMed:26954535).  Cyclochlorotine is formed by the nonproteinogenic amino acids L-2-aminobutyrate (2Abu), L-beta-phenylalanine (beta-Phe), the unique L-cis-3,4-dichloroproline Pro(Cl(2)) and two L-serines (Ser) (PubMed:26954535).  The condensation of the 5 building blocks is performed by the cyclochlorotine synthetase cctN, a nonribosomal peptide synthetase (PubMed:26954535).  The assembled linear pentapeptide is then assumed to be released through cyclization by the terminal condensation-like domain of cctN (PubMed:26954535).  Incorporation of the alternative substrates allo-threonine or alanine by the domains A3 or A1 respectively may lead to the production of the variants hydroxy-cyclochlorotine and deoxy-cyclochlorotine, respectively (PubMed:26954535).  CctP probably acts as a phenylalanine aminomutase and provides the uncommon building block beta-Phe (PubMed:26954535).  Furthermore, 2Abu can be synthesized from threonine by one of the threonine dehydratases and transaminases localized outside of the cluster (PubMed:26954535).  The biosynthesis of the unusual dichloroproline moiety remains elusive since the actual halogenase still awaits to be detected, with the possibility that proline halogenation is accomplished by a so far unknown type of halogenase (PubMed:26954535).  Finally, the cluster encoded transporters cctQ and cctS are most likely responsible for cyclochlorotine secretion and thereby may contribute to intrinsic resistance (PubMed:26954535).  The functions of the remaining proteins encoded by the cluster (cctM, cctO, cctR and cctG) have not been identified yet (PubMed:26954535).
What are the official names of this protein?
Phenylalanine aminomutase (L-beta-phenylalanine forming), PAM, Cyclochlorotine biosynthesis protein P.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
Protein: IF2_SALPB
Sequence: MTDVTLKALAAERQVSVDRLVQQFADAGIRKSADDSVSAQEKQTLLAHLNREAVSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEEQAKREAQQKAEREAAEQAKREAAEKAKREAAEKDKVSNQQTDDMTKTAQAEKARRENEAAELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTATPEPVEDTSDYHVTTSQHARQAEDENDREVEGGRGRGRNAKAARPAKKGKHAESKADREEARAAVRGGKGGKRKGSSLQQGFQKPAQAVNRDVVIGETITVGELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEAVMSDRDTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETDNGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAGVPVVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFVHVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESFLDKGRGPVATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGPSIPVEILGLSGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDEVKVKIIGSGVGGITETDATLAAASNAILVGFNVRADASARKVIESESLDLRYYSVIYNLIDEVKAAMSGMLSPELKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGTIKRHNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRVGDMIEVFEIIEIQRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RETN_BOVIN
Sequence: MKALSFLFIPVLGLLVCGQSLCPIDKAISEKIQEVTTSLVPGAVRIIGLDCRSVTSRGSLVTCPSGFAVTGCTCGSACGSWDVRAETTCHCQCAGMDWTGARCCRLHIQ
What is the function of this protein?
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells.  Potentially links obesity to diabetes (By similarity).
What are the official names of this protein?
Resistin.
What is the protein family that this protein belongs to?
Belongs to the resistin/FIZZ family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOA2_FRATF
Sequence: MALENLLHPTNIKIDEYAKNATKFSFEALERGVGYTLGFALKQTMLYSIAGACVTSIKINDGKVTSLEDVIPCDETVADIILNVKSLSVTLAEDVETGTITFELSGSEEEIFSEEAKLSEGLAITEEVFICSYNGGKKLKIEAKVEKGVGFRPAQDNFKDCEFLLDATFSPVVFCDFEIKDARVGRRTDLDKLELNIKTNGNVNCEEALRLAATKIQNQLRNIVDIEEINKGIFVEDPKDINPILLKHVEELNLTARSSNCLKAVNIRLIGELVQKTENELLKAPNFGKKSLTEIKDKLSELGLSLGTLIENWPQDL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha 2, RNAP subunit alpha 2, RNA polymerase subunit alpha 2, Transcriptase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: 5HT6R_MOUSE
Sequence: MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNFFVTDSVEPEIRQHPLGSPMN
What is the function of this protein?
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen.  The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.  It has a high affinity for tricyclic psychotropic drugs (By similarity).  Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (PubMed:25078650).  Is an activator of TOR signaling (PubMed:23027611).
What are the official names of this protein?
5-hydroxytryptamine receptor 6, 5-HT-6, 5-HT6, Serotonin receptor 6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAMP_CRODC
Sequence: MQGFFWKTWLVLAVCGTPASLAHRPLSYGEALELAVSVYNGKAGEASLYRLLEAVPQPEWDPSSEGSQQLNFTLKETACQVEEERSLEECGFQEDGVVLECTGYYFFGETPPVVVLSCVPVGGVEEEEEEEEEEQKAEAENDEEVEKEKGDEEKDQPKRVKRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF
What is the function of this protein?
Potent antimicrobial peptide against Gram-negative and Gram-positive bacteria.  Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane.  Low hemolytic activities have been observed on mammalian cells.
What are the official names of this protein?
Cathelicidin-related peptide isoform 3, Cathelicidin-related antimicrobial peptide, CRAMP, Vipericidin.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: SSUB1_PSESM
Sequence: MATFDLRNTPSVTIPAPVQLRNVVRQFGRQRVIDGLDLDIAAGEFVALLGASGSGKTTLLRTLAGLDSIDSGELRVPVARAAVFQEPRLMPWKSAWKNVVLGLRVNDAKARAHAALTEVGLAHRLNAFPATLSGGEAQRVALARGLVREPKLLLLDEPFAALDALTRIRMHQLIIDLWRKHTPAVLLVTHDVDEAILLADRVIVLADGKIADDIRIDLPRQRDSGQAGFQLIRSRLLGLLGVKGAEPDTAPQASAPDSTFSELRRVASAR
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TATB_BRASB
Sequence: MFDIGWSELLVIGVVALIAIGPKELPGVLRMVGQWMGKARRMASEFQGQFQEAMREAEMADLKKSFDEVKEAASGFSPSGMMSSLQRDVDKALDIEGVDKPVESQPAASAAPETSATVEAPATPTTPEPPRVETFVEADAHQAVGEPLAIVREIKPEPQPQSLDGAAPAEAERLKDAKAS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.