PharMolix/UniProtQA huggingface dataset:
Protein: PFDB_METAR
Sequence: MNELPPQIQNQLAQIQQVQQQAQALMQQKAQVEMLLRETERAFEELQKTEEGAEVYKGAGELLIKAKREDVLKDLEEKKDNFDVRLKSLSRQEERLQSRFNQLQEQLKSALGKMQGQGPATGGRAE
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIP_DIDVI
Sequence: HSDAVFTDSYTRLLKQMAMRKYLDSILN
What is the function of this protein?
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
What are the official names of this protein?
Vasoactive intestinal peptide, VIP, Vasoactive intestinal polypeptide.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: NRFA_SALA4
Sequence: MARKTLRARRFFSLIFPFFFITSVYAEQTPESAKTVTVEAKNETFAPQHPDQYQSWKATSEQSAREDALAEDPRLVILWAGYPFSRDYNKPRGHAYAVTDVRETLRTGAPKTAEDGPLPMACWSCKSPDVARLIQQEGEDGYFHGKWARGGPEIVNDLGCADCHNTASDDFAQGKPALTLSRPYAERAMEAIGKPFDKAGRFDQQSMVCGQCHVEYYFDGKNKAVKFPWDEGMKVENMEQYYDTIAFSDWTNSLSKTPMLKAQHPEYETWSAGIHGRNNVTCIDCHMPKVQNAEGKLYTDHKIGNPFDNFAQTCANCHTQDKASLQKVVAERKQAIHDLKIKVEDQLVHAHFEAKAAWDAGATDAEMKPILNDIRHAQWRWDLAIASHGIHMHAPEEGLRMLGSAMDKAADARTKLARLLATKGITHEIPLPDISTKEKAQKAIGLNMQQINAEKQDFLKTVVPQWEDQARKNGLLSQ
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TNF15_HUMAN
Sequence: MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL
What is the function of this protein?
Receptor for TNFRSF25 and TNFRSF6B.  Mediates activation of NF-kappa-B.  Inhibits vascular endothelial growth and angiogenesis (in vitro).  Promotes activation of caspases and apoptosis.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted.
Protein: YQJB_BACSU
Sequence: MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDNKVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKGTDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEIAIEHKALIKKQDIPIE
What are the official names of this protein?
Putative L,D-transpeptidase YqjB.
What is the protein family that this protein belongs to?
Belongs to the YkuD family.
Protein: DNAK_XYLFT
Sequence: MGKIIGIDLGTTNSCLAIIEGGKGRVIENSEGDRTTPSIVAYTKDGEVLVGAAAKRQAVTNPKNTFYAVKRLIGRKFGDAEVQKDLDLVPYKITQHDNGDAWVATADGKKLAPQEISAKVLEKMKKTAEDFLGEKVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKKGGDRKIAVYDLGGGTFDVSIIEIAEVDGEKQFEVLATNGDTFLGGEDFDKRVIDYLVDEFNKDQGIDLRKDPLALQRLKDAAERAKIELSSSQQTEVNLPYITADASGPKHLNIKLTRAKLEALVDDLVRKSIEPCRIALNDAGLRTSDVQEVILVGGQTRMPKVQQAVADFFGKEPRKDVNPDEAVALGAAIQGGVLAGDVKDVLLLDVTPLSLGIETMGGVFTKIIEKNTTIPTKASQVFSTAEDGQSAVTVHVLQGEREQARFNKSLAKFDLAGIEPAPRGQPQIEVSFDIDANGILHVSAKDKKTNKEQKVEVKAGSGLSDSEIQQMVADAEAHREEDKKFQELVQARNHADGLIHSTRSAIKEHGSKVGGELIGRVEASLAELEAAVKGDDKNQIEAKSKTLEEVAQSLHMAATAEQQSGSTGAGAGASAKVDDVVDAEFTEVKADKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: FZL_ARATH
Sequence: MRTLISHRQCVTSPFLISAASPPFPGRCFKLSSFTPPRHRRFSSLSIRNISHESADQTSSSRPRTLYPGGYKRPELAVPGLLLRLDADEVMSGNREETLDLVDRALAKSVQIVVIDGGATAGKLYEAACLLKSLVKGRAYLLIAERVDIASAVGASGVALSDEGLPAIVARNTLMGSNPDSVLLPLVARIVKDVDSALIASSSEGADFLILGSGEEDTQVADSLLKSVKIPIYVTCRGNEEAKEELQLLKSGVSGFVISLKDLRSSRDVALRQSLDGAYVVNNHETQNMNELPEKKNSAGFIKLEDKQKLIVEMEKSVLRETIEIIHKAAPLMEEVSLLIDAVSRIDEPFLMVIVGEFNSGKSTVINALLGKRYLKEGVVPTTNEITFLCYSDLESEEQQRCQTHPDGQYVCYLPAPILKDINIVDTPGTNVILQRQQRLTEEFVPRADLLVFVLSADRPLTESEVAFLRYTQQWKKKFVFILNKSDIYRDARELEEAISFVKENTRKLLNTENVILYPVSARSALEAKLSTASLVGRDDLEIADPGSNWRVQSFNELEKFLYSFLDSSTATGMERIRLKLETPMAIAERLLSSVEALVRQDCLAAREDLASADKIISRTKEYALKMEYESISWRRQALSLIDNARLQVVDLIGTTLRLSSLDLAISYVFKGEKSASVAATSKVQGEILAPALTNAKELLGKYAEWLQSNTAREGSLSLKSFENKWPTYVNSKTQLGIDTYDLLQKTDKVSLKTIQNLSAGTTSKRLEQDIREVFFVTVGGLGAAGLSASLLTSVLPTTLEDLLALGLCSAGGYVAIANFPYRRQAIIGKVNKVADALAQQLEDAMQKDLSDATSNLVNFVNIVAKPYREEAQLRLDRLLGIQKELSDIRSKLQLLQVDIDNLHVSRDEMRL
What is the function of this protein?
Probable membrane-remodeling GTPase that plays a unique role in the in the determination of thylakoid and chloroplast morphology and regulates organization of the thylakoid network.  Not involved in the determination of mitochondrial morphology or ultrastructure.
What are the official names of this protein?
Probable transmembrane GTPase FZO-like, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Localizes in a punctate pattern in chloroplasts.
Protein: LEXA_MANSM
Sequence: MKPIKALTARQQEVFNFLKHHIETTGMPPTRAEISRELGFRSPNAAEEYLKALARKGVVEILSGTSRGIRLLVDTEESANDEDAGLPLIGRVAAGEPILAEQHIEGTYKVDADMFKPQADFLLKVYGQSMKDIGILDGDLLAVHSTKDVRNGQVIVARIEDEVTVKRLERKGDVVYLHAENEEFKPIVVNLKEQPNFEIEGIAVGIIRNNAWM
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: URED_BURM7
Sequence: MSAHEPHTSLVRPAAKAWHARLELGFERQPGGRTALAHRRHVGPLRVQRALYPEGDAICHAVIVHPPGGVAGGDRLEIDVRLDAGTHAVLTTPGATKWYKSNGLDARQRIDIDVGAHAKLDWLPQNNLFFDAAHASLEFVLALGDGASVLGWDATQLGRQAAGEAWSAGSIASFSKIVGPSGRPLWVERARLDAGDPLRAAPQGLGGFAVYGTLWALGAACTEALAESIAPALPFDDALRAGVTCVAPGTLLIRALAHSMEALQRLLAEQWLALRPIVHGVDPKPLRLWQT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_RICCN
Sequence: MKQIINPLKGNNNKVPIWFMRQAGRYLPEYKKVRETTKNFLDFCYDVSKATEVTLQPIKRYGFDAAIIFSDILVLPHALGWEVDFKENIGPILKQFKSQEDFKYLQINPNYKLEKVYEIIKKVKKELPSPISLIGFAGSPWTVMSYMLEGKGKQDFKTSKKFIYENKILAEELLNFITEKTADHLINQAKSGADVLKLFDSWSGVLAEEEFTEFVIEPTKKIILKVKEVFPKTPIIAFPKGAGLLYEKFIKEVPIDVLAVDQMVPLEKMKEWSDKVIVQGNLDPVVLLTNKEIIKEKTYKILQVMKGKNFIFNLGHGILPETPTENVEFLTEYVRLYEEKNSNSTF
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_GEOTN
Sequence: MKAAIIGAMEEEVAILRSRMEEREEVVIAGCEFSTGRLDGVEAVLLKSGIGKVNAAMGTTLLLDRFRPDFVINTGSAGGFLPSLRVGDLVISDEVVHHDVDVTAFGYAYGQVPGLPARYRADEALVEAAKQAAAQLDGLQAAIGLIATGDSFMNDPKRVEFVRGQFPELCAVEMEAAAIAQVCVQFGTPFVIIRALSDIAGEESNVSFEQFLETAAKHSAELVLSMLTVVQSKAKQ
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: RSMG_CLOBB
Sequence: MKFYDLMCKAAQDVGLELSKEQYEKFIIYKNLLQEWNEKVNLTAITEDEEIIKKHFIDSIKAFKRDEFKEAKTLIDVGTGAGFPGIPVAIMNENIQVTLLDSLNKRVNFLNLVTEKLGLKNVVAIHSRAEDGARQKNLRESFDIATSRAVANMSVLSEFCLPYVKINGHFIALKGPAVEEEIKDSDKAITTLGGQLLDICEVEIEDTELKHNLVVVKKIKECPKAYPRKAGNVTKKPIK
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y995_METJA
Sequence: MYGDYMKYMKKIVLFLIINILPILILGLYLYANIGGAEDVKEVIENSPFKEFTYIDHKTLMMLKNDVNLKNMPEFYKESIILINGIYIGNHGSFGIKIPLGFLIKYIPIDNFKYYNGVLIKNLNEDDLGKAEMNDLVNTIPPNYKDVLIYRENYTIGIYYDLNSNKTYLIEVFRKPNNQEIDTEKLRNELLQKTNAVDCNVVDMGDKVYVYLEFNGIDLNLINNGIT
What are the official names of this protein?
Uncharacterized protein MJ0995.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MTC2_ZYGRC
Sequence: MAVDKLPDFISGLRFMVAAKKHLVYFYSMKESGSPTSEQIEIERQTSLLKNIVERSYLQERVSCYVLKNIPQEGLPTYNDQTHTGIEIIIIPQVHTLTKGDQNVLVRMMMASQVSRPVRLFIGMIPWDTTKESAMSGDIELALSSRITSEDWLKHKFWFACYEPDENEVFSPLIGALPESLEKAQYTDVHANRSIHRYILDVMIHLRMHKLLDTTKGGGIHTSALRDVLALSQLLALYRFNKAFVTPEHVKLACIWYFPLHVEFLKGSAMDTSVLYGSRPELVDGLLKCIADVKLSNTVETENPLFLETIVVQDVLNKVVPPV
What is the function of this protein?
May be involved in telomere capping.
What are the official names of this protein?
Maintenance of telomere capping protein 2.
What is the protein family that this protein belongs to?
Belongs to the MTC2 family.
Protein: RD28_PHYIT
Sequence: MRVGFVFALLVVSVIVCFNGLTSAESTVVMNNRNPDSINVPISDDITSRNLRASGEERAYAFVDKIKSLFSRPGISQKVESLQKNPAMVKNLEKAALSQKGSSKVRDWFMHMYNNSSKRDKFFILATLVMFPIGVWAVVTNYRR
What is the function of this protein?
Effector that is required for full virulence (PubMed:24130484).  Targets host NTP1 and NTP2 transcription factors and prevents their pathogen-associated molecular pattern (PAMP)-triggered re-localization from the endoplasmic reticulum into the nucleus, where they contribute to prevent disease progression by P. infestans (PubMed:24130484).
What are the official names of this protein?
RxLR effector protein PITG_03192.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host endoplasmic reticulum membrane; Single- pass membrane protein.
Protein: UBC6_DEBHA
Sequence: MASRQSQKRLTKEYKAITLNPPPYVSAKPNDENILEWHYVITGPPHTPFEEGQYHGILRFPSEYPFKPPSISMITPNGRFACNTRLCLSMSDYHPDTWNPAWSVATILTGLLSFMTGDESTTGSITTSDNVKKRLARSSKEWNNAENQRFTKQFPDLVAQNKVDVAARNAREQAAATTDSTDPEKPFDVRENIDSLDPEDRARLLVEQDDHSTPSFGVQRFTLVGVVVAAFIAAYFNFFSRT
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system.  Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 6, E2 ubiquitin-conjugating enzyme 6, Ubiquitin carrier protein UBC6, Ubiquitin-protein ligase UBC6.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane.
Protein: YHV4_LACHE
Sequence: MHNSIAYDKDGNSTGQKYYAYG
What are the official names of this protein?
Uncharacterized protein in hlv 3'region, ORF4.
Protein: RL10_WOLSU
Sequence: MTKTEKTQIIETLTAEFKASSAIAVCDYKGLTVRQFEALRRAARDNGAKVQVVKNTLAGIALENADAKGLELKETNVFVWSDDQIALSKTIMKFAETSNEKFKVKFGYYEGSVVDAAHIETVSKLPSRDELIGMLLSVWTAPARYFVTALDNLKKQKEEN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RSMA_SALG2
Sequence: MNNRVHQGHLARKRFGQNFLNDRFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDKLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTMNFGELSAQLGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCQVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPYPVKDIRVLSRITTEAFNQRRKTIRNSLGNLFSVETLTEMGIDPAMRAENISVAQYCQMANYLSENAPLKES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHA_RAT
Sequence: MAGVGAVSRLLRGRRLALAGATRGFHFSVGESKKASAKVSDAISTQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACLTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGRIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTIIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLKHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPPIKANAGEESVMNLDKLRFADGSVRTSELRLSMQKSMQSHAAVFRVGSVLQEGCEKVSQLYGDLQHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIEGQQKKPFAEHWRKHTLSYVDTKTGKVTLDYRPVIDKTLNEADCATVPPAIRSY
What is the function of this protein?
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).  Can act as a tumor suppressor.
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, Flavoprotein subunit of complex II, Fp.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: VP7_ROTP2
Sequence: MYGIEYTTVLTFLISVILLNYILKSLTRIMDFIIYRFLFVIVILSPFLNAQNYGINLPITGSMDTPYINSTQEEMFLTSTLCLYYPTEADTEISDNSWKDTLSQLFLTKGWPTGSVYFKDYTDIASFSVDPQLYCDYNLVMMKYDAALQLDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISMGSSCTIKVCPLNTQTLGIGCLTTDTNTFEEVATAEKLAITDVVDGVNHKLSVTTNTCTIRNCKKLGPRENVAVIQVGGSDILDITADPTTAPQTERMMRVNWKKWWQVFYTIVDYVNQIVQVMSKRSRSLNSAAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: RIMP_HALHL
Sequence: MSQIQTLHSLLEPTVTGLGYELVGVELTGAKGNRTLRVYIDTPAGIRLEDCEAVSHQVSGLLDVEDPIEGAYNLEVSSPGLDRPIFKSADYDRFSGERIKLRLLELYEGRRRVKGVLLGLDGEFVRVRDVDGVELRIPLELIDRARLDLEP
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF3M_YARLI
Sequence: MSDINFMVVDGSLADLVAELTAYIETLGCDELEANCQRALAAGEEPKVFELITQQLPLLNKSSEQQFESVWQLCLHVFSFSESFEWVDAVLKAISGHSNLPRSFNGPAAAGQAVVAVLASLFNMLSSSHDDAQLANTLLAALTTAEETGNLHLLAGQLKSDQTVTWINTWQIEADVRDQLIAKIYSALVQLDEPAKALALLVAAVGNTQTSTFPMTCKLVQQALKSDHVYDFGSILALEPVEDLKTTEQRLFELLTTVASGEVAKMQSLAAGDAKSLIEENDFDAESLLAKTRVIALANLAAESPEIEYSIIAKNLDVSLDTVELWVIDTIRAGLVEGRLSQTKQSFAVHRAQKSGPIAKADWEVISQKLDVWKKSINDVLHVVKQARENANAQKRKIAA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit M, eIF3m.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit M family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MET_OTOGA
Sequence: MKASTVLAPGILALLFTLVQRSNGECKEALAMSKMNVDMKYQLPNFTAETPIQNIVLHEHHIYLGAINYIYVLDDKDLQKVAEYKTGPVLEHPDCFPCQDCSDKANLSGGIWKDNVNMALLVDTYYDDQLISCGSVNRGACQRHVLPRNNAADIQSKVHCMFSPQADEEPGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYFPNHPLHSISVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKYVHAFESNHFIYFLTVQRETLDSQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTRKEVFNILQAAYVSKPGAHLAKQIGVSVNDDILFGVFAQSKPDSAEPMNRSAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRSDEYRTEFTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQIMVSRSGSSTPHVNFHLDSHPVSPEVIVEHTVNQNGYTLVVTGKKISKIPLNGLGCEHFQSCSQCLSAPPFVQCGWCHDKCVRSEECPSGSWTQETCRPAVHKVFPTSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTTNTLKCTVGPAMNEHFNMSIVISNGRETTQYSTFSYVDPVITSISPSYGPKAGGTLLTLIGKYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQIISTEFPVKLKIDLAIREASSFSYQEDPIVYEIHPMKSFVSGGSTITGVGKNLNSVSVPRMVIHVREAGRDFTVACQHRSNAEILCCTTPSLQQLNLQLPLKTKAFFMLDGVLSKYFDLIYVHNPVFKPFEKPVMISMGNENILEIKGNDIDPEAVKGEVLKVGNKSCENIHSRSEAVLCTVPNDLLKLNSELNIEWKQAVSSTVLGKVIVQPDQNFTGLIVGVVSISIILLLLLGLFLWLKKRKQNKDPGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDENFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNIDGEVDT
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.  Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.  Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.  Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.  During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation.  In adults, participates in wound healing as well as organ regeneration and tissue remodeling.  Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
What are the official names of this protein?
Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: REL3_PIG
Sequence: MAKRPLLLLLLAVWVLAGELWLRTEARASPYGVKLCGREFIRAVIFTCGGSRWRRSDMLAHEALGDVFSDTDSNADSELDEAMASSEWLALTKSPETFYGVQPGWQRTPGALRGSRDVLAGLSSNCCKWGCSKSEISSLC
What is the function of this protein?
May play a role in neuropeptide signaling processes.  Ligand for LGR7, RXFP3 and RXFP4 (By similarity).
What are the official names of this protein?
Relaxin-3, Insulin-like peptide INSL7, Insulin-like peptide 7.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RIM1_SCHPO
Sequence: MLFLKSSRAFSKRLFSSSTVRYRDIQRLTLTGNLTKDVERLQSQKGNEYMRYTVASNNGKDVAPTFHSVYVFDSYNFDRLQTILRKGTRVYVEADAVWRSVPAGNEGSQAKMSLRHVSADVLFYPRNKNGDESGEETHPELDADPMINSF
What is the function of this protein?
This protein binds preferentially and cooperatively to ss-DNA.  Involved in mitochondrial DNA replication (By similarity).
What are the official names of this protein?
Single-stranded DNA-binding protein rim1, mitochondrial, Mitochondrial ssDNA-binding protein.
What are the subcellular locations of this protein?
Mitochondrion.