PharMolix/UniProtQA huggingface dataset:
Protein: RISB_ACIC1
Sequence: MTGEGRPDRAVVAAHGIRLGIAASRWNAHVVDAMVERAIEAARSCGVTTPTVVRVAGALELPVVALELAHHHDAVVGLAAVIRGATPHFEYVAQAATMGLTQVAIQTGTPVGDGILTCDSMAQALDRCGLPDSAEDKGWEATVAALDCALVLRDLRSRAAAGMPG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: TRMD_BRUC2
Sequence: MTDLPEKEGGRFHASVLTLYPEMFPGPLGISLAGKALAEGKWQLDTVQIRDFAEGRHRMVDDTPSGGGAGMVMKADVVARALDSVDDGRPMLLMTPRGKPLTQERVRALADGAGAIILCGHFEGVDERVIEGRNLEEISIGDYILSGGETAAIVLLDAVVRLLPGVMGNRESGETESFETGLLEHPHYTRPQEWEGRAIPDILTSGNHGAIDKWRLEQAERITRERRPDLWEAYCKNRRKIGGQ
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURT_WIGBR
Sequence: MVTINTALCKNSTRVMILGSGELGKEIAIECQRLGIEVISVDSYSNAPAMHVSHRHHVIDMLNPKEIKRCINLEHPDFIVPEIEAISTNALIELEKNGYNIVPSAKTIHITMNRKLIRVLVSKKLNILTSEYQFASSFDELKIKTKVIGYPCLIKPIMSSSGKGQSVIYNEKELRHSWEKSQTYGRTSLGEVIIEKIIPFDFEITLLVVNSVDGMHFCLPIGHRQEKGDYQESWQPHKMDNVIFEKAKKISKKIVSYLGGYGIFGVEFFIYKDKVIFSEISPRPHDTGMVTLISQNLSEFALHVRSFLKLPIGKIRQYGPSSSVVICGNELYGNKISFSNIECINTNQQIRIFSKPNIKGYRRLGVILDQDETIERSLRKAKKTASKILIKT
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: METK_JANMA
Sequence: MANEYLFTSESVSEGHPDKVADQISDAILDAIFQQDPKARVAAETLCNTGLVVLAGEITTFANVDYIEVARQTIKRIGYDNADYGIDYKSCAVLVAYDKQSPDIAQGVDEGAGIDLDQGAGDQGLMFGYACDETPELMPAAIHYAHRIVERQSELRKDGRLPWLRPDAKSQVTLRYVDGRPVSIDTIVLSTQHAPEMQHKDIEEAVIESIIKPVVPAEWLKDTRFLVNPTGRFVIGGPQGDCGLTGRKIIVDTYGGAAPHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLAERAQIQISYAIGVAKPTSVMVTTFGTGKISDEKIAQLVLEHFDLRPKGIVQMLDLLRPIYQKTAAYGHFGREEPEFSWERTDKAQALRAAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NS1_MUMIM
Sequence: MAGNAYSDEVLGTTNWLKEKSNQEVFSFVFKTEDVQLNGKDIGWNNYKKELQEDELKSLQRGAETTWDQSEDMEWESTVDEMTKKQVFIYDSLVKKCLFEVLSTKNIAPADVTWFVQHEWGKDQGWHCHVLIGGKDFSQAQGKWWRRQLNVYWSRWLVTACNVQLTPAERIKLREIAEDSEWVTLLTYKHKQTKKDYTKCVLFGNMIAYYFLTKKKISTSPPRDGGYFLSSDSGWKTNFLKEGERHLVSKLYTDDMRPETVETTVTTAQETKRGRIQTKKEVSIKTTLKELVHKRVTSPEDWMMMQPDSYIEMMAQPGGENLLKNTLEICTLTLARTKTAFDLILEKAETSKLTNFSLPDTRTCKIFAFHGWNYVKVCHAICCVLNRQGGKRNTVLFHGPASTGKSIIAQAIAQAVGNVGCYNAANVNFPFNDCTNKNLIWVEEAGNFGQQVNQFKAICSGQTIRIDQKGKGSKQIEPTPVIMTTNENITVVRIGCEERPEHTQPIRDRMLNIHLTHTLPGDFGLVDKNEWPMICAWLVKNGYQSTMASYCAKWGKVPDWSENWAEPKVPTPINSLGSARSPFTTPKSTPLSQNYAITPLASDLEDLALEPWSTPNTPVAGTAETQNTGEAGSKACQDGQLSPTWSEIEEDLRACFGAEPLKRDFSEPLNLD
What is the function of this protein?
Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication.  Also plays a role in viral packaging and transactivation of several promoters.  Binds site-specifically to 2-3 approximate tandem copies of the tetranucleotide 5'TGGT3' within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR).  Cooperatively binds Ori with host PIF and probably other host factors, which activate the nickase function of NS1.  Becomes covalently attached to the 5' end of the nick and provides a 3'OH for priming DNA synthesis.  The helicase activity unwinds DNA in a 3'-5' direction on the longer strand.  Participates in the transcriptional regulation of several promoters including the viral p38 promoter that regulates the expression of VP1 and VP2 transcripts.  Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition.  These arrests may provide essential cellular factors for viral DNA replication.  Promotes apoptosis in host cell.
What are the official names of this protein?
Initiator protein NS1, NS1, NCVP1, Non-capsid protein NS-1, Non-structural protein 1, Non-structural protein NS1.
What is the protein family that this protein belongs to?
Belongs to the parvoviruses initiator protein NS1 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RS16_ERWT9
Sequence: MVTIRLARHGAKKRPFYQVVVTDSRNARNGRFIERVGFFNPIASGQAEALRLDLDRIEHWVGQGATLSDRVNALIKQAKKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SYT_HALMA
Sequence: MSTVTVTLPDGTPLEVERGSTVEDVAYEIGPGLGDDTVAGVVDGELVDKHAPLTADVELEIVTESSDEYLDVLRHSAAHVFAQALQRLYSDAKLTIGPWTDNGFYYDITGVDIDEDDLEAIEAEAEEIIEEDLDIERELVDRDDAFERYEDNQFKQDILETEAADDEEVSFYTQGEFEDLCQGPHVESTGEIGGFALLEISAAFWRGEEENETLTRVYGTAFPTEDALDEFLEQRRKAEERDHRKIGQEMDLFSIDETTGPGLPLYEPNGKKILNELSDYVAGLNRDAGYDEVETPHVFRTELWKKSGHYENYVDDMFLLDVNDEEYGLKPMNCPGHATIFEQNSWSYRDLPVRYFEDGKVYRKEQRGELSGLSRTWAFTIDDGHLFVRPDQIEEEVLATVDIILDTLDTFNLDYTVQFATRPEKSVGGDEIWEKAESQLESVLEEQDIDYVVEEGDGAFYGPKIDFAFEDALGRHWDGPTVQLDFNMPERFDLSYTGEDNEEHRPVMIHRALYGSYERFFMVLTEHYNGKFPPWLAPEQIRLLPVSDDNITYCEEIQDELDDFRVTIEDRSWTVGKKIQQAHDDRVPYMCVIGDNEEEAGTISVRDRKEREEKDIDIAEFRDHLETEVEQQRTAVTFLAGR
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: V2R1_MOUSE
Sequence: MASRQISLALGFLAFLWAVLGAQNKTEEVQCRLMAKFNLSGYVDAKNHSLVIAGLFPIHSRIIPVDEAILEPVSPMCEGFNFRGFRWMKTMIHTIKEINERKDILPNHTLGYQIFDSCYTISKAMESSLVFLTGQEEFKPNFRNSTGSTLAALVGSGGSSLSVAASRILGLYYMPQVGYTSSCSILSDKFQFPSYLRVLPSDNLQSEAIVNLIKHFGWVWVGAIAADDDYGKYGVKTFKEKMESANLCVAFSETIPKVYSNEKMQKAVKAVKTSTAKVIVLYTSDIDLSLFVLEMIHHNITDRTWIATEAWITSALIAKPEYFPYFGGTIGFATPRSVIPGLKEFLYDVHPNKDPNDVLTIEFWQTAFNCTWPNSSVPYNVDHRVNMTGKEDRLYDMSDQLCTGEEKLEDLKNTYLDTSQLRITKQCKQAVYAIAHGLDHLSRCQEGQGPFGSNQQCAYIPTFDFWQLMYYMKEIKFKSHEDKWVILDDNGDLKNGHYDVLNWHLDDEGEISFVTVGRFNFRSTNFELVIPTNSTIFWNTESSRRPDSFCTQVCPPGTRKGIRQGQPICCFDCIPCADGYVSEKSGQRECDPCGEDDWSNAGKSKCVPKLVEFLAYGEALGFTLVILSIFGALVVLAVTVVYVIHRHTPLVKANDRELSFLIQMSLVITVLSSLLFIGKPCNWSCMARQITLALGFCLCLSSILGKTISLFFAYRISVSKTRLISMHPIFRKLIVLVCVVGEIGVCAAYLVLEPPRMFKNIEIQNVKIIFECNEGSVEFLCSIFGFDVLRALLCFLTTFVARQLPDNYYEGKCITFGMLVFFIVWISFVPAYLSTKGKFKVAVEIFAILASSYGLLGCLFLPKCFIILLRPKRNTDETVGGRVPTVDRSIQLTSASVSSELNSTTVSTVLDE
What is the function of this protein?
Putative pheromone receptor.
What are the official names of this protein?
Vomeronasal type-2 receptor 1, Putative pheromone receptor V2R1, V2Rx.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HSLU_SHEFN
Sequence: MSEMTPREIVHELDAHIIGQQNAKRSVAVALRNRWRRMQLEPELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVEQIIRDLTDSAVKMTREQQMKKCRHRAEEMAEERILDALLPKPKDDWDTDQKDDSTTRQVFRKKLREGQLDDKEIEIDVAAPQVGVEIMAPPGMEEMTNQLQGLFQNLGQSTSKRKKLKIKDAYKQLVEDEAAKLVNQEDLKEQAIELVEQNGIVFLDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQMSKPSDLIPELQGRLPIRVELDALTAADFKRILTEPFASLTEQHVALMNTEGVTIEFTESGIERIAEAAWQVNERTENIGARRLHTVMEKLMEEISYDASEKSGSKFVIDAEYVNDHLDTLVQDEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLB_APLJU
Sequence: ALSAADAGLLAQSWAPVFANSDANGASFLVALFTQFPESANFFNDFKGKSLADIQASPKLRDVSSRIFARLNEFVSNAADAGKMGSMLQQFATEHAGFGVGSAQFQNVRSMFPGFVASLSAPAADAAWNSLFGLIISALQSAGK
What are the official names of this protein?
Globin, Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RXRA_XENLA
Sequence: MSSAAMDTKHFLPLGGRTCADTLRCTTSWTAGYDFSSQVNSSSLSSSGLRGSMTAPLLHPSLGNSGLNNSLGSPTQLPSPLSSPINGMGPPFSVISPPLGPSMAIPSTPGLGYGTGSPQIHSPMNSVSSTEDIKPPPGINGILKVPMHPSGAMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDSKDCMIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKERNENEVESSNSANEDMPVEKILEAEHAVEPKTETYTEANMGLAPNSPSDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPLEVEALREKVYASLEAYCKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
What is the function of this protein?
Receptor for retinoic acid that acts as a transcription factor.  Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.  The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription.  The high affinity ligand for rxrs is 9-cis retinoic acid.  In the absence of ligand, the rar/rxr heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression.  On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation.
What are the official names of this protein?
Retinoic acid receptor RXR-alpha, Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y876_CAUSK
Sequence: MADDAAPHADVLNSTAQGQLKSIIDRVERLEVEKTEIAEQIKEVYLEAKGNGFDVKILRKVVRLRKTDRAKRQEEDAILDLYLSAIGEI
What are the official names of this protein?
UPF0335 protein Caul_0876.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: AROE_SYNJA
Sequence: MDRRISGSTQLLGLIGDPVAHSLSPAMHNAALAAMGEDYCYVPFPVAAERLAVAVAGLAAIGVRGFNVTIPHKQAILPLLSQVEARAAAVGAVNTVYALPEGGWGGTNTDIDGFVQPLLGLEKGIPTLILGSGGAARAAIQGCLELGLGPVRVAGRSPEKLRALQQTWPQVETLSWAELDRHLAETRLLVNTTPVGMHKPGSLAELSPLSWEQLRLLPAGATVYDLVYVPDPTPLLRMAAELGHTPIGGLEMLIHQGAKALSLWLGGKLVPVEVMRQAARQQLAQIGDPNS
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: MINE_PSYA2
Sequence: MSKKKGFWSSLFGTDDNSNTGSANMATERLKVIVASENRLSNRLTADRIEKMKREILEVVNKYVNGVQIDDVNINHRSEDSLDVLEMNINLPEHKK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: GLGC_SHIFL
Sequence: MVSLEKNDHLMLARQLPLKSVALILAGGRGTRLKDLTNKRAKPAVHFGGKFRIIDFALSNCINSGIRRMGVITQYQSHTLVQHIQRGWSFFNEEMNEFVDLLPAQQRMKGENWYRGTADAVTQNLDIIRRYKAEYVVILAGDHIYKQDYSRMLIDHVEKGARCTVACMPVPIEEASAFGVMAVDENDKIIEFVEKPANPPSMPNDPSKSLASMGIYVFDADYLYELLEEDDRDENSSHDFGKDLIPKITEAGLAYAHPFPLSCVQSDPDAEPYWRDVGTLEAYWKANLDLASVVPELDMYDRNWPIRTYNESLPPAKFVQDRSGSHGMTLNSLVSGGCVISGSVVVQSVLFSRVRVNSFCNIDSAVLLPEVWVGRSCRLRRCVIDRACVIPEGMVIGENAEEDARRFYRSEEGIVLVTREMLRKLGHKQER
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: CDH_ECOSM
Sequence: MKKAGLLFLVMIVIAVVAAGIGYWKLTGEESDTLRKIVLEECLPNQQQNQNPSPCAEVKPNAGYVVLKDLNGPLQYLLMPTYRINGTESPLLTDPSTPNFFWLAWQARDFMSKKYGQPVPDRAVSLAINSRTGRTQNHFHIHISCIRPDVREQLDNNLANISSRWLPLPGGLRGHEYLARRVTESELVQRSPFMMLAEEVPEAREHMGSYGLAMVRQSDNSFVLLATQRNLLTLNRASAEEIQDHQCEILR
What are the official names of this protein?
CDP-diacylglycerol pyrophosphatase, CDP-diacylglycerol phosphatidylhydrolase, CDP-diglyceride hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Cdh family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: AROB_STACT
Sequence: MELMTTYKSNNYPIIIKNNAITELTELLKPYRDVVFIVDKNVEFALPEKIQQALSSTSSEQFTHILKVEGNETTKTFAVYQHIIEELLEQSITRNTCIIAIGGGVIGDFAGFVAATILRGVDFIQVPTTILAHDSSVGGKVGINTPQGKNLVGAFYRPTAVLYDLDFLNTLPYTEISSGYAEVYKHALLNGEEAQLEIETAFPDKKALESLVSLDKFLLKGIQTKLNIVIEDEHEQGKRKFLNLGHTFGHAIEYNQKIPHGHAVMIGILYQFIVANELLNTQFDIMHYINYFKNLDYPLEKVLDTNFEPLLALMSKDKKNDKSGIQMVLLKEIGKPKVIHVNNEVLEKSFATLQNYLK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPTE2_MACFA
Sequence: MCRVMKASFSRKVKLELCLLSDCALLSSSSAPTNELSGTNLEAHINESPDPNALVGVIIERSPSDSTQTNEFKGATKETLTIETPHSSECKGAGLLSPVSKSMLERLSKFEVEDAENVASYDTKIKKIVRSIVSSFAFGIFGVFLVLLDVTLLLADLIFNDSKLYIPLVYRSISLAIALFFLMDVLLRVFVEGRQHYFSDLLNVLDTAIIVTPLLVDVVYIFFDIKFLRNIPRWIHLVRLLRLIILIRIFHLIHQKRELEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHPNHYRVYNLCSERAYDPKYFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDPANIVAIHCKGGKGRTGTMICAFLIASEIFLTAEESLYYFGERRTDKTNSSKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGVGTGGVCDLKVRIVMEKKVVFSSTSLGNCSILHDIETDRVLIDVFSGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQSNRHILHSFRLVFT
What is the function of this protein?
Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate.
What are the official names of this protein?
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: MIPEP_MOUSE
Sequence: MLLAAGARYARRLCGRGAAAALQGRTGRSCARDVSTSWSPVGAAFNVKPQSHLWNLLGERRGLFGVPELSTPEGFQVAQEEALKKTEWLVERACSTPPGPQTVLIFDELSDCLCRVADLADFVKIGHPDPAFREAAQEACRSIGTMVEKLNTNVELYQSLQRLLGDKKLMESLDAETRRVAELFMFDFEISGIHLDEEKRRRAVDLNVKILDLSNAFLMRTNFPNKIRKSLLPEHIQHHFARDGSHLIIDGLHAEASDDLVREAAYKIFLYPNADQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAQTPETVMQFLEKLSEKLSERTRKDFKMMQGMKTKLNPQNSKLMPWDPPYYSGVIRAERYNIEPSLYCPFLSLGACMEGLNVLFNKLLGITLYAEQTFKGEVWCNDIRKLAVVHESEGLLGYIYCDFFQRANKPQQDCHFTIRGGRLKEDGSYQLPVVVLMLNLPHASRDFPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFSNDYRVVSQFAKHYQTGQPLPKAMVSRLCESKKVCTAAEMQLQVFYAALDQIYHGQHPLKKSTTDILMETQEQFYGLPYVPDTAWQLRFSHLVGYGAKYYSYLMSRAVASMIWKECFLQDPFNRAAGERYRREMLAHGGGKEPMLMIQGMLQKCPSIDDFVDALVSDMNLDFETFFLDSK
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: MARE2_HUMAN
Sequence: MPGPTQTLSPNGENNNDIIQDNNGTIIPFRKHTVRGERSYSWGMAVNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKLEHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKEYDPVEARQGQDAIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPAAKPGSTPSRPSSAKRASSSGSASKSDKDLETQVIQLNEQVHSLKLALEGVEKERDFYFGKLREIELLCQEHGQENDDLVQRLMDILYASEEHEGHTEEPEAEEQAHEQQPPQQEEY
What is the function of this protein?
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes.  May play a role in cell migration (By similarity).
What are the official names of this protein?
Microtubule-associated protein RP/EB family member 2, APC-binding protein EB2, End-binding protein 2, EB2.
What is the protein family that this protein belongs to?
Belongs to the MAPRE family.
Protein: NUSB_SHESA
Sequence: MKPSERRKARRLAVQAIYSWQLSGNNIADVEHEFLTEQSLDGVDVAYFRELFAGVATKKTQLDELFIPHLDRPIDEVSPVEKAIVRLAAYELTFRKDVPFKVAINEAIELAKAFGADESHKFVNGLLDKLVARK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: CSK2B_HUMAN
Sequence: MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
What is the function of this protein?
Regulatory subunit of casein kinase II/CK2.  As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610).  Participates in Wnt signaling (By similarity).
What are the official names of this protein?
Casein kinase II subunit beta, CK II beta, Phosvitin, Protein G5a.
What is the protein family that this protein belongs to?
Belongs to the casein kinase 2 subunit beta family.
Protein: PDIA1_MOUSE
Sequence: MLSRALLCLALAWAARVGADALEEEDNVLVLKKSNFEEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAAKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFKNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLSDTAAAESLVDSSEVTVIGFFKDVESDSAKQFLLAAEAIDDIPFGITSNSGVFSKYQLDKDGVVLFKKFDEGRNNFEGEITKEKLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSSFKRAAEGFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESDELTAEKITEFCHRFLEGKIKPHLMSQEVPEDWDKQPVKVLVGANFEEVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIIIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGDDEDLDLEEALEPDMEEDDDQKAVKDEL
What is the function of this protein?
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds.  At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell.  May therefore cause structural modifications of exofacial proteins.  Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins.  At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins.  At low concentrations, facilitates aggregation (anti-chaperone activity).  May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis.  Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP (By similarity).  Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).
What are the official names of this protein?
Protein disulfide-isomerase, PDI, Cellular thyroid hormone-binding protein, Endoplasmic reticulum resident protein 59, ER protein 59, ERp59, Prolyl 4-hydroxylase subunit beta, p55.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein. Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. Localizes near CD4-enriched regions on lymphoid cell surfaces. Colocalizes with MTTP in the endoplasmic reticulum.
Protein: T185B_HUMAN
Sequence: MNPRGLFQDFNPSKFLIYTCLLLFSVLLPLRLDGIIQWSYWAVFAPIWLWKLLVVAGASVGAGVWARNPRYRTEGEACVEFKAMLIAVGIHLLLLMFEVLVCDRVERGTHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALKLDRIIHWPWLVVFVPLWILMSFLCLVVLYYIVWSLLFLRSLDVVAEQRRTHVTMAISWITIVVPLLTFEVLLVHRLDGHNTFSYVSIFVPLWLSLLTLMATTFRRKGGNHWWFGIRRDFCQFLLEIFPFLREYGNISYDLHHEDSEDAEETSVPEAPKIAPIFGKKARVVITQSPGKYVPPPPKLNIDMPD
What are the official names of this protein?
Transmembrane protein 185B, Protein FAM11B.
What is the protein family that this protein belongs to?
Belongs to the TMEM185 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL21_SHEPW
Sequence: MYAVFQSGGKQHRVEAGHTVRLEKLEVATGETIEFDQVLLVADGETVHVGAPLVEGGKVVAEVVSHGRAEKVTIVKFRRRKHHDKKMGHRQWFTEVKITAISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.