Protein: PRLS_FUNXX
Sequence: MSSTEPIAVIGSACRFPGSSDRPSKLWELLREPRDLLQKVSERRRWHPDAFYHSDPEHHGTTNVRSSYFLDEDPADFDNAFFNIQPSEAEAIDPQQRMLMETVYDSLCSAGQTIEGLRGSSTAVIVGTMCDDWSGVLYKDWETIPQYSATGMGRSIMSNRVSYFFDWHGPSMTLDTACSSSLVAVHLAIQALRTGESRVAVAAGANLLLGPGMYIAEANLHMLSPKGRSAMWDKDVDGYARGEGIASVILKPLSAAIEDGDHIECLIRATGVNQDGRTQGLTMPSATAQAALIRETYARAGLDIDKPEDRPQFFHAHGTGTPAGDPQEAEAISKAFYSQDASDSLYVGSIKTVIGHTEGTAGLASLLGTSLALQHGMVPPNMHFNELNPRIAPFYGNLQVPTTAKPWPKLLPGQPRRASVNSFVFVIYLDSWLTWPPNAGFGGTNAHAILEAYEPPSVSPSAGPLFSPLTISAATEKSLRALMSSYSEYLKANPKTSLRDFAYTLQERRSTLAFRAAIAASTSDEAAIKIDGLLDAEDARELSTKHFGIPSPRLLGVFTGQGAQWPRMGARLVEASPFVATRLDELDASLASLPESIRPEWTLKEQMLEDAATSRVAEAAVSQPLCTAVQILLVDLLSVAGVRFHAVVGHSSGEIGAAYAAGLLSASSAIRIAYLRGLYAKLANSPNGNIRGAMMAAGTSFEDASEFCQLEGFEGRIQVAAVNSASSITLSGDEDAIAEAVEIFKDEGKFARQLKVDTAYHSAHMLPCSKPYLKSLEAMTDVLGADASGEGKPAWYSSVHEGEIMKPAALNPQYWVSNMTNTVLFAPAVAAAVAQSGPFDMALELGPHPALKGPCLDTLAEALGDRIPYSGLLSRGQDDISEMSAALGSVWSNLGAGSVSFETFEKSISGDLKGRNLIADLPKYEFDHSRSFWTISRAVGAQLVAHDPPHPVLGRRCVDRETSREIQWRNILSPKEVPWLKGHRIQGGIVYPAAGFVAMAVEAMRALAGKSSINLIKIDNLFIGRAIAFNEETSTVETLFSVKVVSSSDESIQASFSCYSGAPHEPGTSMGLNAEGIVTVTLADHEADVILFVEPKDFNMTEIETDRFYDQFQRLEYEYSPPFRGMLAIKRKKGHARGTIEDQSGSDWEDQFLIHPGMLDTAFQSSSAAFSCPGDGMMWGLYIPAGIQSIVINPYFTPAGMGKQQTLPWEAIARSMHKARSTMDINIFSQDSTHTFIQVEGLELMPFTAARPEDDAVIFSRFDYKIDGPSGDIAVADDGFTAEALENAIKGERVSFYYLRRLVESITPEEKANAPRYYRHLLDWASHVVDRVKSGKNPFVQSSWQLDTEEQIKAIWDKYGDRVDVRLIESVGKHLPDVIRKGTSILEHMEGLFEFYDQGLGLDMANRHLARMVAQVGHRYPQMRVFEIGEPRKPAPMLLCCHSDSRVLGAGTGGSTRTILSYLGDMFSSYTYTDISSGFFEAAQDRFKDFESRMVYKTFDMERDPESQGFVEGSYDLVLASNCLHATDKLEEMMTNARRLLRPGGYLIALELTSNETMRVGLPMGSLPGWWVGAESGRPWGPTVTLPQWDSLLRKCGFGGIDTSTPLLHKLHVSTVFAAQAVDDRVSLLRSPLASITVLPPTDAPRLVVVGGEALATHRIAERVASLLGPRFSDIARVTSFESLDIDALPYGSTVLSLSELDEPLFKNMNPAKLDALKTLWRQAGKILWVTRGARAEEPFSSMMLGLGRAMTHEYPNISLQILDLDRLEDEEKTAQLFTAELLRLEVLKKWQHEAQGEVDFLWSIEPEVCFEGGARLIPRLYKCRPANDRYNSARRPVMTEIDPRETPILFASEGASYELQHPSPLRIPSAPPAVSKTRTVNVSHFLLQTVHMSSAGRFMLFAGADRYTGERLLGLSHTTESQPTVPTEWTFPIASEGTNPAEALSSVYGQIIAREILKMVPKGSSIVVHEPDPSLGAALLQQAEACATEVVLTTSRKGSVSSEGRFIPANLSRRLVKKALPDSTSLYVDLSHAGESSEAGKLIGKCLPGSCSTYGSGYFHGTTPELRPGSSSSQLSAIFKAACEAAFEGQCQTAIPDIVQLQDVPSLRAIGRPLTVVDCVSTATVPVNVQTVDSGMIFRADKTYFLVGMSGQVGQSLCQWMVERGARYVVLTSRHPQVHPEYVKSMEAMGATIRVLPLDITSRDSLQQCYAEMCKTMPPVAGVAQGAMVLRDSMFDGLSFENLTAVLDPKVTGTQLLDELFYDAPLDFFIVMSSLTSVVGNSGQSNYTAANMFMVALAEQRRKRGVAGSAIAISSLIGIGYVERSEDFTGDYFEKIGYRNISEQDLHQLFAEAILVGRPGCRESSEITTGLEPFYPERNAKAQFFDDIRFNHFILERHDAQNLGGKGSAVPVRVQLAEVKTRDEAAVIIKGEANSRKNDFETQKADSRTDGFLARLRRTLMISQDEAVNEKASLVEQGIDSLMAVEVRSWFLKELEVDIPVLKILGGSSITDLLNEALERVPVSVVDLKAMANTKASTPEHRKVSVPPPPSVEVKSSSPGSSSEPQSSPADSPSRPSTPLRTPMTEMEESKTLAPVVVEKPKVYPAAKEEASEMSYGQARFWFLSGYLEDKTSFNMTVMFKLTGKLQVARLESAVRTVAQRHEALRTRFFWSGEGDRRTPMQGVLSESPIQLEHVRIESEADAQKQLAKMHEYVWDLNSWEAARMVLLTVDDDVHYFMVSGHHISWDGYSFTVLFVDLDAAYCGRPLAPLGPECQYPAFAAWQRDTYAAGAMKKAIDTYYRPMIDPHAKAIPLFPFAKSPTRPLLDHFEQFEAKATLQPALVSKLKQLSRKNGATMFHLYLAALQALVFRLLPEEDDFYLGVADANRMDKSFMGSLGFFLNLLPVRFDRSQPGTKISEIIKDTRNKAYKALENSFVPWNVLLQELKIPRTNTEAPIFQLFVDYRQIARDRAQWCGCALSDEDWLNARNGYDLTLGITDNPTGESLLSLRFQKKLYSEHSTNLFLRSYVTVLESFATGVDLEVSELPRWAPSDVEATLEAGKVYRKLMTNPQGPCTQLDWPATVSHRIDEMIHEHTAQPALKDGLGNSLTYGQMRDRINMISAALIAGGAIEGSSIGVFQNPSADWICSMLAIFRIGATYVPLDLRNSIARIVSIVADVQPTVILSDRYTTTKIRQIGAVQATEIVVSDIATSVSAPDLPNKAAPDSRAVILFTSGTTGKPKGVILTHANLRAQCEGYSRMVDLPSMVSVVLQQTIYNFDVSLDQIFAALADGGCLYVVPAEKRGDPQAITEIMAEQGVTYTVATPSEYEIWFRYARDNLARCKSWGYAFGGGEHLHSGLIHEFSSLAAQHIPGLRLFNNYGPTEASLAITKGEVQHSDPGLEDHVPAGWIIPNYKVAVVDEKLQPVPFETSGEILAGGPGVASGYLGQDELTREKFIAGVRIHPLAAKSANTWYRTGDRGRLRRDGALYVDGRILGDSQVKIRGFRVELQEIEAVLLEAAKGALSHAVITARGTGEDRFLAAHVVFAPDFPQHRRQATIHHLESKLPLPPYMQPTVIVPLASIPVTSNFKLDRKAIQALPLPETDGLGENLADVEKSVAMLWKSIIPHGVRDLTPETNFFDVGGNSILLVKLKAAMSRELKVTPLLIDLMNSSTLGGMARIVRASSGARVINWEAETSVPESLRALVKQKKTLSRSKRKNENLVVVLAGATGYLGRHILARLVNAPEVSEINCLVRDEGLEAATSSLQNSPKVRLIPADLSQPDIGLSLAKFSDLSQRADIVVDCAANRSFWDGYETLRTVNLDAVKELARLCVTNGASLHFVSSGAVQAYENSAPPTDGSDGYVASKWAAETFLRRAAESLGLQVHIHRPLGSADVGAPDSTPDRKNPSTKDEIQRDLDHILLKLGKRPDFSAVTGYVDVTPVNSVVSDMVAAMIQEISSGHGGAMLRVTEHRGRLRLHIKEFGDHIGASSQLSALPTMNPLFWFADAKKAGFAQLITSQRLVMHNKEGELVTRR
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of pyrrolocin, a bright yellow trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:25226362, PubMed:25351193).  The PKS module of prlS together with the enoylreductase prlC catalyze the formation of the polyketide unit which is then conjugated to L-serine by the condensation domain of the prlS NRPS module (PubMed:25226362).  Diels-Alderase gNR600 is involved in endo-selective Diels-Alder cycloaddition to form the decalin ring (By similarity).  Subsequent methylation is carried leads to pyrrolocin A (PubMed:25226362).  The methyltransferase involved in that last step has not been identified yet and is probably located outside of the prl cluster (PubMed:25226362).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase prlS, Pyrrolocin biosynthesis protein S.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.