PharMolix/UniProtQA huggingface dataset:
Protein: S27A1_MOUSE
Sequence: MRAPGAGTASVASLALLWFLGLPWTWSAAAAFCVYVGGGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPCIFQAVARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVKVNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGRYVPLDERVHARICAGDFSL
What is the function of this protein?
Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:7954810, PubMed:9786857, PubMed:9671728, PubMed:10471110, PubMed:12235169, PubMed:11970897, PubMed:15699031, PubMed:28178239, PubMed:24858472, PubMed:19527715) (Probable).  Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10593920, PubMed:12235169, PubMed:12937175).  May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation (PubMed:14991074, PubMed:15897321).  Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:12235169).  May be involved in regulation of cholesterol metabolism (PubMed:12235169).  Probably involved in fatty acid transport across the blood barrier (By similarity).
What are the official names of this protein?
Long-chain fatty acid transport protein 1, Arachidonate--CoA ligase, Fatty acid transport protein, Fatty acid transport protein 1, FATP-1, Long-chain-fatty-acid--CoA ligase, Solute carrier family 27 member 1, Vlc27a1, Very long-chain acyl-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Mitochondrion outer membrane. Endomembrane system; Single-pass membrane protein. Cytoplasm. Note=Plasma membrane and intracellular membranes, at least in adipocytes (PubMed:10593920, PubMed:11970897, PubMed:28178239). In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake (PubMed:11970897, PubMed:28178239). Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1 (PubMed:11970897, PubMed:28178239). Predominantly cytoplasmic in myocytes (PubMed:15897321).
Protein: GPMA_CORJK
Sequence: MSEQNNSHGNLILLRHGQSEWNASNQFTGWVDVRLTEKGRAEAVRGGEMIKEAGLEPTILYTSLLRRAITTANIALDAADRHWIPVVRDWRLNERHYGALQGLNKAETKDKYGEEQFMAWRRSYDTPPPAIDADNEYAQTNDPRYADLSEIPATECLLDVVKRFIPYYEEEIEPRVKNGETVLVAAHGNSLRALVKHLDKISDEDIAGLNIPTGIPLVYNIDADGKVLNPGGDYLDPEAAAAGAAAVAAQGQAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: PAP1_MCV1
Sequence: MNGAQFELLREYLGRPPTLNQYFIFKPQARAIQRIMRFDTDVFFALIKKNKKRFFARIGGSASEINARVLSYFVKQRATTKVGRILSIIELQSVLVNSYTEIMGVLTLPAPPVYNSVVRLHYCSMERLAEEVLWSYNVAFRSGKVMGRHCVSNLVVHVNKLMSEYLRRHNRTAICYGSYSLHLLNSRIEYGDIDILQTNARLFLINLAFLIYFITGRNVLLLKVPYLKSYIVMQDEEGRHIIDSFNIRQGTMQNVPKVLVDNIYIIDPVVQLMNTLKMLSQIDRLEDLGERMAKMRLRLATLLEYARYHHCVSFGGGARLRLHMRLDAGARIVLVDTRCYGLGYRECRCYLDEARLLQDISKLNADAAVVDFEAVSNSVFLIHQGIMYTYFSNTVLLRSEDAIHDVSERAVCAHITLYHLLVGCNYQELLADLLNSLVSREKCPVVGVVARDKKVGRHGVIDIEKDVITH
What is the function of this protein?
Polymerase that creates the 3'-poly(A) tail of mRNA's.
What are the official names of this protein?
Poly(A) polymerase catalytic subunit, Poly(A) polymerase large subunit, PAP-L.
What is the protein family that this protein belongs to?
Belongs to the poxviridae poly(A) polymerase catalytic subunit family.
Protein: GRGB_PENSQ
Sequence: MPTTMQALVGAESGGYRLAENVDIPVPQRGSILVQVHAVALNPRDAKIVDFSNAPGSLGGCDFAGTVKKVGEGVTRFKEGDRVLAVTFGSNALDKTKGAFAEFALAEEDISCRIPEDFSFTQACSIGLSMATAGLAIFQAPGLELSLHGGKGEAVLVSGGATATGTMATQLLRMAGYTPIVTCSPANNALCQSYGAAACFDYHSPACGADIRVQTNDSLRYVLDCVTDTTTMKMCYEAIGSSGGSYIALETIATTVKYTRRDVRADWFLADAIMGNGVQMAGTYGRAPSPELRRFGKQLFALAENWLHDGSIRHHPLEIQDGGLANMPQALNDMKLGKVHAKKLVVPILGH
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of gregatin A, a fungal polyketide featuring an alkylated furanone core (PubMed:32275405).  The PKS grgA synthesizes C11 and C4 polyketide chains in the presence and absence of the trans-enoyl reductase grgB, respectively (PubMed:32275405).  The polyketide transferase grgF is then responsible for the fusion of the two carbon chains to produce the furanone skeleton of gregatin A (PubMed:32275405).  Next, the cytochrome P450 monooxygenase grgG accepts performs the oxidative cyclization to furnish the gregatin scaffold and leads to the formation of desmethylgregatin A (PubMed:32275405).  Finally, the O-methyltransferase grgD methylates the carboxyl group of desmethylgregatin A to provide gregatin A (PubMed:32275405).
What are the official names of this protein?
Trans-enoyl reductase grgB, Gregatin A biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: MURD_GEOSW
Sequence: MKQTAFYQQRRVLVIGLAKSGFAAAKLLHELGAIITVNDQKPFEENKEAQQLEQLGIRVICGGHPLELLDEPFDLVVKNPGIPYTNPMVKKAMEKGLPVVTEVELAYHISEAPFIGITGSNGKTTTTTLIYEMLREGEKRPLLAGNIGTAACEVAKKAEASNWLVTELSSFQLAGIRDFRPRISVLLNIFDAHLDYHGTKEAYAQAKANIFKNQTNEDYAVINADDELVMQLAENIHAQKVAFSATKVLGRGAYINNGFIYWNDEAVIAVADIVLPGKHNLENILAAVAVAKLAGVDNKSIYQVLTTFTGVKHRLQYVATIDGRKFFNDSKATNILATQKALSAFEKDSVILLAGGLDRGNEFDALLPYLHNVKAVVLFGQTAPKIARVAKQAGIETIEYVDNVEKAVPVAYQLSEPGDVILLSPACASWDQYKTFEQRGDIFIGAVHKLK
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_MYCCT
Sequence: MPKMKTKKSLAKRVTVKSNGTLKRAKAYRSHRATGKTTKQKRQLSKATIISKVDMKNLKGLLQ
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ATPG_MACFA
Sequence: MFSRAGVAGLSAWTLQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARIYGLGSLALYEKADIKVPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVATLTAAGKEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFDEGSVIFNRFRSVISYKTEEKPIFSLNTIASAESMSIYDDIDADVLQNYQEYNLANIIYYSLKESSTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(1) domain and the central stalk which is part of the complex rotary element.  The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
What are the official names of this protein?
ATP synthase subunit gamma, mitochondrial, ATP synthase F1 subunit gamma, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: HIS4_PSEA7
Sequence: MLIIPAIDLKDGACVRLRQGLMEDATVFSDDPVAMAAKWVDGGCRRLHLVDLNGAFEGKPVNGEVVTAIARRYPDLPIQIGGGIRSLETIEHYVRAGVSYVIIGTKAVKQPEFVGEACRAFPGKVIVGLDAKDGFVATDGWAEVSEVQVIDLARRFEADGVSAIVYTDISKDGMMQGCNVEATAALANATRIPVIASGGIHNLGDIQKLLDARTPGIIGAITGRAIYEGTLDVAEAQALCDNFKA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAD50_PYRFU
Sequence: MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGTKYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAISAFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREVLNLDKFETAYKKLSELKKTINNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLEETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDAYLALKEFKNEYLDKKYKIEKELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKLAILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLEELETKKTTIEEERNEITQRIGELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDRKSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTLEGRIRGLAEDLKKLAPLEKKLAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLRELEEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAEVEADIERIEKKLSQLKQKYNEEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLEKAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIALGLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEVVS
What is the function of this protein?
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair (PubMed:11029422, PubMed:18957200).  The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA (PubMed:18957200).  Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex (PubMed:24493214).  The ATP-bound conformation promotes DNA end binding and end tethering, and alters Mre11 nuclease activity (PubMed:24493214).  ATP hydrolysis promotes both Mre11 activity as well as HerA/NurA activity (PubMed:24493214).  Has also reversible adenylate kinase activity (PubMed:17349953).
What are the official names of this protein?
DNA double-strand break repair Rad50 ATPase, pfRad50.
What is the protein family that this protein belongs to?
Belongs to the SMC family. RAD50 subfamily.
Protein: CBID_SALTO
Sequence: MTYDLPPLREPDLPRTAKVRPVALRTGWTTGACATAATKAALTALVTGVSPEQVEIGLPAGRRVCFPVARCDRTADGVEAVVVKDAGDDPDVTHGAELTATVGWRWVPGLALEGGPGVGTVTKPGLGLTVGGPAINDTPRRMIGEAVAEVVDLAVVGVRVVISVPRGEIMARKTTNRRLGIIGGISILGTTGVVRPFSTASWRASVVQAVQVAAAQGEQTVVLCTGGRTERAARELLPELPEVCFVEVGDFTGAAVTAAVTHGLSGVAFVGMAGKLAKLAAGVLMTHYTRSKVDLSLLGAVTVEAGGSADLAAAVTAANTGRHAYELWEAAGLLGPAGDLLCRRVRTVLRRFAGDAVTVDVAMVDFAGARRVAASGRWSQ
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: ACPS_SULDN
Sequence: MIGIDIIKISRMGALLERFGSKAMGRFLSKDEIELVKNHKTASGFWAAKEACSKALGVGIGAECGFHDITIFKSSNGAPNIRLSQKIVKEFNVKSISLSITHDGEYAIAVVTIESTAANKI
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_PHOLL
Sequence: MFTINAEVRKEQGKGASRRLRRANKFPAIVYGGNQELVSIELDHDQVINMEQKAEFYSDVLTLVIDGKETKVKVQAVQRHPFKPKLAHIDFLRA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: MDH_VIBMI
Sequence: AAGGIGQALALLLKNRLPAGSDLALYDIAPVTPGVAADLSHIPTPVTIKGYAGEDPTPALEGADVVLVSAGVARKPGMDRADLFNVNAGIVKALAETIAVVCPKACVGIITNPVNTTVPIAAEVLKKAGVYDKRKLFGVTTLDVIRSETFVAALKDKDPGQVRVPVIGGHSGVTILPLLSQVEGVTFTDEEVAALTKRIQNAGTEVVEAKAGGGSATFSMGQ
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: RPO7_SACS2
Sequence: MYKLIKARSIVRIPPNEFGKPLNEIALNELRQQYQEKILKDLGLVLAILNVKTSEEGILVFGDGATYHEVEFDMITYVPVVQEVVEGEVLQVDNYGIFVNLGPMDGLVHISQITDDTLKYDNVRGIIFGEKSKKVIQKGDKVRARVISVASTVTGRLPRIALTMRQPYLGKLEWITQTKK
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo7, DNA-directed RNA polymerase subunit E, DNA-directed RNA polymerase, subunit E'.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_DINSH
Sequence: MAQIDGLPPLREVIAAHKLSAKKSLGQNFLLDLNLTARIARVPGDLSGADVLEVGPGPGGLTRGLLAEGARKVLAIEKDARCLPALQQIAAAYPGRLEVIEGDALEVDATAYLSPPIHIAANLPYNVGTELLVRWLTPPDWPPFWRTLTLMFQREVAERIVAKPGSKAYGRLAILAQWRAEAEIALTLPPQAFIPAPKVHSAVVHLRARTEPRYPADAAVLSRVVATAFNQRRKMLRASLKGLTPGIEDHLAAVGIDPTRRAETLSLEEFCALARQIAAG
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA_ERWT9
Sequence: MQVLHVCSELFPLLKTGGLADVVGALPAAQIAAGDDTRVLLPAFPDLKKGITQIQVVAQLQTFAGYVELHFGHFNGVGIYLIDAPGLYDRPGSPYHDESQYAYSDNYLRFALLGWVSCELACGLDPWWRPEVVHAHDWHAGLSCAYLAARGRPAKSVFTVHNLAYQGLFNARHMEQIQLPHSFFDVYGMEFHGQISYLKAGLFYADHVTAVSPTYAREITQPEFGYGMEGLLKQRLLEGRLSGILNGVDPAIWNPAHDLLLAARYNRDVLDAKRENKRQLQIAMGLKIDEKAPIFAVVSRLTKQKGLDLVLEALPGLLEQGGQLVVLGAGDAELQQGFLAAAAENPGQVGVQIGYHEAFSHRIMGGADVILVPSRFEPCGLTQLYALKYGTLPLVRRTGGLADTVNDCSLENLADGIASGFSFEDSNAWSLLRAIRRSFVLWSRPSLWRYVQRQAMGMDFSWQVAAVAYRDLYQRLL
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: ARCC1_ENTFA
Sequence: MGKKMVVALGGNAILSNDASAHAQQQALVQTSAYLVHLIKQGHRLIVSHGNGPQVGNLLLQQQAADSEKNPAMPLDTCVAMTQGSIGYWLSNALNQELNKAGIKKQVATVLTQVVVDPADEAFKNPTKPIGPFLTEAEAKEAMQAGAIFKEDAGRGWRKVVPSPKPIDIHEAETINTLIKNDIITISCGGGGIPVVGQELKGVEAVIDKDFASEKLAELVDADALVILTGVDYVCINYGKPDEKQLTNVTVAELEEYKQAGHFAPGSMLPKIEAAIQFVESQPNKQAIITSLENLGSMSGDEIVGTVVTK
What is the function of this protein?
Catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP.  Can also catalyze, although with low efficiency, the phosphorylation of bicarbonate, leading to the formation of carboxyphosphate, an unstable intermediate found in the reactions catalyzed by carbamoyl-phosphate synthase and biotin carboxylase.  Can also use acetate.
What are the official names of this protein?
Carbamate kinase 1.
What is the protein family that this protein belongs to?
Belongs to the carbamate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GILT_BOVIN
Sequence: MASSPLLFVLLLLLPLEVPAATRWSLLEALPEGAAPCQVGELCLQASPQKPDVPLVNVSLYYEALCPGCREFLIRELFPTWLMVLEILNVTLVPYGNAQERNVSGKWEFTCQHGERECLLNKVEACLLDQLEQKIAFLTIVCLEEMDDMEQNLKPCLQIYAPKVSADSIMECATGNRGMQLLHINAQLTDALRPPHKYVPWVVVNGEHMKDAEHLLHLVCRLYQGQKPDVCQLTAELSKEVHFK
What is the function of this protein?
Lysosomal thiol reductase that can reduce protein disulfide bonds.  May facilitate the complete unfolding of proteins destined for lysosomal degradation.  Plays an important role in antigen processing.  Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds.  Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).
What are the official names of this protein?
Gamma-interferon-inducible lysosomal thiol reductase, IFI30 protein.
What is the protein family that this protein belongs to?
Belongs to the GILT family.
What are the subcellular locations of this protein?
Secreted. Lysosome.
Protein: RL3_CAUVC
Sequence: MTLPTQRTGVIAKKLGMTRFFDEAGQHVPVTVLSLDGCQVTGVRTVEKDGYTALQLGAGAKKAKNTSNAMRGHFAKAAVEPKRVVAEFRVEENALIEVGAELTADHFVAGQKVDIQGVTVGKGFAGAMKRWNFGGLRATHGVSVSHRSHGSTGNRQDPGRTFPGKKMAGHLGQETVTTLNVTVWKVDVERGLILVKGAVPGHEGSYVKVRDAVKKALPADAPRPGAFRKAGEAAPAAAETPAEEAPAAETEEGEG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: SRFB1_PONAB
Sequence: MAQPGTLNLNNEVVKMRKEVKRIRVLVIRKLVRSVGRLKSKKGTEDALLKNQRRAQRLLEEIHAMKELKPDMVTKSALGDDINFEKICKKPDSTATERAIARLAVHPLLKKKIDVLKAAVQAFKEARQNVTEVESSKNASEDNHSKNTLYSNDNGSNLQREGTVISEQEVKETKILAKKPIHNSKEKIAKMEHGPKAVTIANSPSKPSEKDSVISLESQKTPADPKLKTLSQTKKNKESDSSLSGNSDGGEELCEEEKEYFDDSTEERFYKQSSMSEDSDSGDDFFIGKVRRTRKKESSCHSSVKEQKRLEKVFLKEDTGETHGDTRNDKTKPSTETRKLESVFFHSLSGSKSSRRNFKEQAPKTRSLDFPQNEPQFKNQFNKKLSRRLENTKQQLQLPLHPSWEASRRRKEQQSNIAVFQGKKITFDD
What is the function of this protein?
May be involved in regulating transcriptional activation of cardiac genes during the aging process.  May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).
What are the official names of this protein?
Serum response factor-binding protein 1, SRF-dependent transcription regulation-associated protein.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region.
Protein: AL3A1_HUMAN
Sequence: MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
What is the function of this protein?
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable).  They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable).  Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758).  Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758).  Comprises about 50 percent of corneal epithelial soluble proteins (By similarity).  May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
What are the official names of this protein?
Aldehyde dehydrogenase, dimeric NADP-preferring, ALDHIII, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_VIBVU
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPVAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHQVPGVLSERVLLVGCGKERELGERQYKEIIQKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVEATKDGLYTFDQFKSVKPETRRPLRKLVFNVPTRRELNLGEKAITHGLAIASGVKACKDLGNMPPNIANPAYLASQARRLADDYETITTKIIGEQEMEKLGMSSYLAVGRGSKNESMMSIIEYKGHPDSEAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGAASVFGTMKALAKLNLPVNVIGVLAGCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDVATLTGACVIALGHHITGVLSNHNPLAHELVNASEQSSDRAWRLPMADEYHEQLKSPFADMANIGGRPGGTITAACFLSKFAKKYNWAHLDIAGTAWKSGAAKGSTGRPVSMLVQFLLNRSGQETEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_ACTPJ
Sequence: MRILGIETSCDETGVAIYDEEKGLVANQLYSQIEMHADYGGVVPELASRDHIRKTLPLIQEALKEANLTAADIDGVVYTAGPGLVGALLVGSTIARSLAYAWNVPALGVHHMEGHLMAPMLEDNPPAFPFVALLISGGHTQLVKVEGVGQYEILGESIDDAAGEAFDKTGKLLGLDYPAGVAVSQLAEKGTPNRFVFPRPMTDRPGLDFSFSGLKTFAANTINANLDENGRLDEQTRCDIAHAFQQAVVDTIIIKCKRALQQTGYKRLVMAGGVSANKQLRTDLAEMMKNLKGEVYYPRPQFCTDNGAMIAYTGFLRLKNGETSDLSISVKPRWNMTELPDISTTGG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.