PharMolix/UniProtQA huggingface dataset:
Protein: SHGR2_ARATH
Sequence: MEDRETHLGTREVNETSPDLLKNTPSNIARLEDVIEQCHGRQKYLAQTRSPSDGSDVRWYFCKVPLAENELAASVPRTDVVGKSEYFRFGMRDSLAIEASFLQREDELLSLWWKEYAECSEGPKLQVNSKKKSIETPSEASVSSSLYEVEEERVGVPVKGGLYEVDLVRRHCFPVYWNGDNRRVLRGHWFARKGGLDWLPIPETVSEQLEVAYRNKVWRRRSFQPSGLFAARIDLQGSSLGLHALFTGEDDTWEAWLNVDPSGFSGIVGYTGNGIKLRRGYAGSYSPKPTQEELRQQKEEEMDDYCSQVPVRHLVFMVHGIGQKGEKSNLVDDVGNFRQITAALAERHLTSHQLSTQRVLFIPCQWRKGLKLSGEAAVDKCTLDGVRRFREMLSATVHDVLYYMSPIYCQAIIDSVSKQLNRLYLKFLKRNPDYVGKISIYGHSLGSVLSYDILCHQHNLSSPFPMDSVYKKFFPDEESPPTPAKADKPCSSHPSSNFEPEKSDQLNNPEKITGQDNNTMAKEPTVLEHHDVIQEDPSLISDSVVANVGLERRGGQEDDHHDSSGAISSQDVPDGADCRTPDSPSCSQEQSWDKESVNSNNEERIKLLQDEVNSLRSKVAQLLSENARILSDEKAKTSVAPKELNNEKVQTEDADAPTSFTPFIKYQKLEFKVDTFFAVGSPLGVFLALRNIRLGIGKGKDYWEEENAIEEMPACRRMFNIFHPYDPVAYRVEPLVCKEYLPERPVIIPYHRGGKRLHIGLQDFREDFAARSQRIMNHFDSVRTRVLTICQSKSADNLDEMEETDDEKDDRSYGSLMIERLTGTRDGRIDHMLQEKTFEHPYLQAIGAHTNYWRDQDTALFIIKHLYRELPDGPNSPTESTEGDDSPKDSSRPHSWIDRREADYDDEELPLTFSDKQITRSFSAEAKKYLKKP
What is the function of this protein?
Involved in vacuolar formation or function (e. g.  formation of vacuolar membrane 'bulbs').  Required for amyloplast sedimentation in the endodermis during shoot gravitropism, which are thus acting as statoliths.  Particularly important for the negative gravitropism leading to leaf movement observed in darkness.
What are the official names of this protein?
Phospholipase SGR2, Protein SHOOT GRAVITROPISM 2.
What are the subcellular locations of this protein?
Vacuole membrane. Note=Detected in small organelles membranes.
Protein: ALLB_SALPA
Sequence: MSFDLIIKNGTVILENEARVIDIAVQGGKIAAIGENLGEAKNVLDATGLIVSPGMVDAHTHISEPGRTHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRETIELKFDAAKGKLTIDAAQLGGLVSYNLDRLHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFYKGAQKLGEMDQTVLVHCENALICDELGEEAKREGRVTAHDYVASRPVFTEVEAIRRVLYLAKAAGCRLHVCHISSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDQENQKGMWEKLFNGEIDCLVSDHSPCPPEMKAGNIMQAWGGIAGLQNCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLKHKGRIAPGKDADLVFIQPDSSYVLKNEDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEHGFPVPPKGQFILKHQQ
What is the function of this protein?
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
What are the official names of this protein?
Allantoinase, Allantoin-utilizing enzyme.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
Protein: PB1_HUMAN
Sequence: MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPAYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQAYNLENV
What is the function of this protein?
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).  Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF).  Acts as a negative regulator of cell proliferation.
What are the official names of this protein?
Protein polybromo-1, hPB1, BRG1-associated factor 180, BAF180, Polybromo-1D.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL28_SYNY3
Sequence: MARRCQLTGKKANNGFAVSHSHRRTKKLQQANLQWKRVWWPEGNRFVRLRLSTTAIKTLESKGINAMAKEAGINLNKF
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: HP301_ARATH
Sequence: MVVGGGGEGDQKRSSGEMMAMASLFNDQQNPIQQFQVKFKEVETNFKTWLSKQSIPVEAAVVSTMSGVQGAFIGGLMGTLSPEMPQAGVDPQAIASMKQAQALVGGPWVQARNFAAITGVNAGIASVMKRIRGKEDIESAVVAALGSGFAYSLVSQGLQGQPMNAITTAAGFAVFQGVFFKLGERFSKPSTEDPFFTRGRTMLVKLGLEKYEKNFKKGLLTDPTLPLLTDSALKDANIPPGPRLMILDHIQRDPEIKGKRK
What is the function of this protein?
Together with HP30-2 and HP20, triggers the import and insertion of transit sequence-less multi-pass transmembrane proteins (e. g.  CEQORH) into the chloroplastic inner membrane.
What are the official names of this protein?
Chloroplastic import inner membrane translocase subunit HP30-1, Hypothetical inner plastid envelope protein of 30 kDa 1, AtHP30-1, Hypothetical protein 30.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: RRG1_YEAST
Sequence: MAQNFGKIPSHKSYVLSLYRTVLRNIPKCCHSYAFQYEIKKTLSIQLFKHKHDKSSWSVYTLLNEFSLLNNCLLEGKLQEIKNLMKPLKKMKKQLKTTKILNSLTSLGDVKTNDPEEVRRFHVLSAYIKRKQDLGLLPAYIPKTYQHKLLLPLALNEHACLKLFHIQQKLKNGPPSAGLSYTKEGRNQIWFVRSPINKGRQQSKKLGILIRKERKDSQKNIDNLNFCEINAAWALHEAIWEEYLESKKIIKVNLPKYLEYAANIPKSTKCNPSSQYQKVKEWVDPVREIMFELHSKSFQRVEYFNKYKEKLLKNGGQLAYFDKKSKEMYAKRLTLFRKMSKETLPYVTLFIEGRDLPSVLAKYGF
What is the function of this protein?
Essential for respiratory growth and required for mitochondrial protein synthesis.  Required for vacuolar acidification.
What are the official names of this protein?
Required for respiratory growth protein 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DYLT5_DANRE
Sequence: MSDLAKEKARLLKKRGSLSSLGSHEVRAIGKTKDSISTLSYMEEHGHHDDIQRPTVQMENTYRITPSRRFPVLTVKDLLKDVLTSYLQEEKYETELCRQMTKTITEVVKARVKDLMIPRYKIIVVISIGQIKDQNIRMGSRCLWDDNHDNFSSHIFKNNSLFAAATVFGVYFE
What are the official names of this protein?
Dynein light chain Tctex-type 5, Tctex1 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain Tctex-type family.
Protein: TRPC_HERAR
Sequence: MSDILNKILAVKADEVAAAKKYRSLASLRSEVEADKDARAALRNFEGALRQKIAAGNAGIIAEIKKASPSKGIIRPDFQPDQIATSYAQHGAACLSVLTDVQFFQGSPDYLKQARAACSLPVLRKDFMIDPYQIYEARSWGADCILLIVAGLDHGLMAELEACAHELGMHVLVEVHNGEELNAALRLKTTLLGVNNRNLRTFETSLQTTLDLLPRIPPEKLVITESAIVTPDDVKKMRDADVHAFLIGETFMRAPDPGQELNRLFS
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: TVBJ2_HUMAN
Sequence: MGTRLFFYVALCLLWAGHRDAGITQSPRYKITETGRQVTLMCHQTWSHSYMFWYRQDLGHGLRLIYYSAAADITDKGEVPDGYVVSRSKTENFPLTLESATRSQTSVYFCASSE
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 10-2.
What are the subcellular locations of this protein?
Cell membrane.
Protein: SH21A_MOUSE
Sequence: MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICLNAP
What is the function of this protein?
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7.  In SLAM signaling seems to cooperate with SH2D1B/EAT-2.  Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2.  However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (By similarity).  Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions (PubMed:22683124).  Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation (PubMed:19648922).  In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (PubMed:22683124).  May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
What are the official names of this protein?
SH2 domain-containing protein 1A, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2191_ARCFU
Sequence: MLYGRIFFNSGVQLLSMADKKFSLIALVSFTALAIIVLYHNISPYLTPSDLIAQGKAENVQVVGKIVSVNGNTFQLSDGKNTITAVYNGTVQRYDAEVVVVGNWDGKVLHATKVLQKCHTEYKGG
What are the official names of this protein?
Uncharacterized protein AF_2191.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TSPO_SCHPO
Sequence: MDLNYQVFTSISKNWWSASLVPVACGWFIGNSYKPRKDYENKKQPKFHPPASAFGPAWTLLYLTMGYASHLAYKADPLMITNASRNGSILYIAQLAANFAWMPLFYGLAKPKLALADLGILTGLVGWLAKTWWPLAPTASKWLIPYLAWLGYAGYLNLGYCLLN
What is the function of this protein?
May play a role in the transport of porphyrins and heme.
What are the official names of this protein?
Translocator protein homolog.
What is the protein family that this protein belongs to?
Belongs to the TspO/BZRP family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: TX29A_PHONI
Sequence: SFVFYLFTLITVVRAEEFILENEAEDIAPAVHGESGRECIGHRRSCKEDRNGCCRLYTCNCWYPTPGDQWCKCQLW
What are the official names of this protein?
U10-ctenitoxin-Pn1a, U10-CNTX-Pn1a, Neurotoxin Pn3-5A.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 02 (plectoxin) family. 09 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MANA_SHIFL
Sequence: MQKLINSVQNYAWGSKTALTELYGMENPSSQPMAELWMGAHPKSSSRVQNAAGDIVSLRDVIESDKSTLLGEAVAKRFGELPFLFKVLCAAQPLSIQVHPNKHNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVSLLQPVAGAHPAIAHFLQQPHAERLSELFANLLNMQGEEKSRALAILKSALDSQQGEPWQTIRLISEFYPEDSGLFSPLLLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPANQLLTQPVKQGAELDFPIPVDDFAFSLHDLSDKETTISQQSAAILFCVEGDATLWKGSQQLQLKPGESAFIAANESPVTVKGHGRLARVYNKL
What is the function of this protein?
Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide.
What are the official names of this protein?
Mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI.
What is the protein family that this protein belongs to?
Belongs to the mannose-6-phosphate isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_BRUC2
Sequence: MDNLANQGVIVLAAGGTGGHLFPAEALAHELRARGWDVHLATDARAQRFVGAFAQDHVHVIRSATIAGRNPVALLKTFWSLWQGNLDSRKLFRRLKPKLVVGFGGYPTLPPLYAASNMGIPTLIHEQNAVMGRANKGLAGRVKAIAGGFLPENSGAYAAKTVITGNPVRPPVLVAAATPYTPAGKDDRFRLLVFGGSQGAQFFSQAIPAAVALLPEHERARLLITQQARKEDEASARKAYEKLGVPADVAPFFNDMPARMADAHFVIARSGASTVSEITVIGRPAMLVPFPHALDHDQAANAAALAAAGGAEVVRQADLSPQRLAEMLQSAMNEPERLEQQAKAAKSVGKPDAARLLADLAEAIASGKTVQEFKEGNRP
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ARLY_HERA2
Sequence: MWGGRFSGSLAEHMRLFNDSFPIDRRLWAEDIRGSIAWANGLERAGILQAAECQELIAGLRQVYQEFEEGLFLPLTSDEDIHTAVERRLGDFIGALAGKLHTGRSRNDQVATDTRLWTLGALKLADDLIRDVQAALLEQAKAVGEAMLPGYTHLQRAQPVLLSHALLAHFWRLDRDRQRLHDATKRVSVLPLGSGALAGTAFAVDRAALAAELGFTSISQNSLDATSDRDYIVEILAAIALLGVHISQLAEDWIIWSSSEWGFVALDDAYSTGSSLMPQKKNPDSLELARGKSGRLIGNLITVLTLLKGLPSAYDKDLQEDKAPLFDAIDTLSLTLPVVAGAIRTARFNTERMESALDDAMLATDVADELVRRGVPFREAHHIAGRLVREAEQRGVGMRQLPAESFVAAHPSLTDVAGLFDFARSVAMRDVPGGTAPNAVRDQLIAAQHVLAEG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFNG_MACFA
Sequence: MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGDPDVADNGTLFLDILRNWKEESDRKIMQSQIVSFYFKLFKNFKDDQRIQKSVETIKEDINVKFFNSNKKKRDDFEKLTNYSVTDSNVQRKAVHELIQVMAELSPAAKIGKRKRSQMFRGRRASQ
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: MSH3_ASPFU
Sequence: MTLSSSQSSPPSTQNLKRKQQTISSFFTKRAPSAEKRSNDIEDGRATTQKGAEMPLRETAGDQNNLEDDEDGDVVVRAPKRVKTNGVDPENGFGRNIKEASNIARRPDPPLSSSQRTNLYKFASSQADDAGIEKTDDPEARQRQLEREKLHKLFVKKLGGADCLIGIGRDATTEAPSGTEDVAEGDEDDESPPQPRSKGKGLSKKGGSKLTPLEKQVIEIKRKHMDTILVVEVGYKFRFFGEDARIAAKELSIVCIPGKMRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVSAGYKVGVVRQLETAALKAAGDNRNAPFSRKLTNLYTKGTYVDDVEGLDGATPAASGGASPATGYMLCITETNAKGWGNDEKVHVGIVAVQPNTGDVIYDDFDDGFMRSEVETRLLHIAPCELVIVGELSKATEKLVQHLSGSKLNTFGDKVRVDRVAKKKTAVAESHSHVANFYAAKLKAANTADDAPASNLLQKVLNLPEQVTVCLSAMIQHLTEYGLEHIFELTKYFQHFSSRSHMLLNANTLVSLEIYQNQTDHSAKGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKERLEERVNAVEELKSPERTVQAERLKIMLGKIKSDLEKNLIRIYYGKCTRPELLTVLQTLQTIAQEYVDVKTPQDSGFTSPILGEAIARVPSILGDVVKFLNKINMHAARNDDKYEFFRESEETEGISEHKCGIASVEHELEEHRSVAAGILKWPKVTYVTSSGIEYLIEVENSAAAIKRVPASWVKVSGTKKVSRFHTPEVIQLLRQRDQHKEALAAACDQAFAALLAEIASNYQSFRDCVQSLATLDCLLSLAAIASQPGYVKPEYTDQTCIHVEQGRHPMVEQLLLDSYVPNDIDLDSDKTRALLVTGPNMGGKSSYVRQIALIAIMAQIGSYVPARSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRTIRSLTLFITHYQHLSNMAQSFPDHELRNVHMRFTESGSGKDEEITFLYEVGEGVAHRSYGLNVARLANLPAPLLEVARQKSSELEERIRRRRLARLLADVGGLIEDPAKGDENFFQRLISNAEQL
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  Msh3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein msh3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: VL1_HPV12
Sequence: MAVWQAAHGKVYLPPSTPVARVQSTDEYIQRTNIYYHANTDRLLTVGHPYFNVYDNTGKKLEVPKVSGNQHRVFRLKLPDPNRFALADMSVYNPDRERLVWACRGLEISRGQPLGVGSTGHPYFNKIKDTENSNNYATGSKDDRQNTSFDPKQIQMFIVGCTPCVGEHWEKALPCGDAPAENGVCPPIELKNTFIEDGDMADIGFGNMNFKTLQQNRSDVSLDIVNETCKYPDFLKMQNDVYGDACFFYARREQCYARHFFVRGGKTGDDIPDAQIDDGNMKNQYYIPGAQDQSQKDIGNAMYFPTVSGSLVSSDAQLFNRPFWLQRAQGHNNGILWANQMFVTVVDNTRNTNFSISIYSDNQNVHDIPNYDSQKFREYLRHVEEYEISLILQLCKVPLKAEVLAQINAMNSSLLEDWQLGFVPTPDNPIHDTYRYIESLATRCPDKNPPKEKPDPYDGLSFWTVDMTERLSLDLDQYSLGRKFLFQAGLQQTTVNGTTKSSSYRSSIRGTKRKRKN
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: LPAKS_ECOLI
Sequence: MNNSRLFRLSRIVIALTAASGMMVNTANAKEEAKAATQYTQQVNQNYAKSLPFSDRQDFDDAQRGFIAPLLDEGILRDANGKVYYRADDYKFDINAAAPETVNPSLWRQSQINGISGLFKVTDKMYQVRGQDISNITFVEGEKGIIVIDPLVTPPAAKAALDLYFQHRPQKPIVAVIYTHSHTDHYGGVKGIISEADVKSGKVQVIAPAGFMDEAISENVLAGNIMSRRALYSYGLLLPHNAQGNVGNGLGVTLATGDPSIIAPTKTIVRTGEKMIIDGLEFDFLMTPGSEAPAEMHFYIPALKALCTAENATHTLHNFYTLRGAKTRDTSKWTEYLNETLDMWGNDAEVLFMPHTWPVWGNKHINDYIGKYRDTIKYIHDQTLHLANQGYTMNEIGDMIKLPPALANNWASRGYYGSVSHNARAVYNFYLGYYDGNPANLHPYGQVEMGKRYVQALGGSARVINLAQEANKQGDYRWSAELLKQVIAANPGDQVAKNLQANNFEQLGYQAESATWRGFYLTGAKELREGVHKFSHGTTGSPDTIRGMSVEMLFDFMAVRLDSAKAAGKNISLNFNMSNGDNLNLTLNDSVLNYRKTLQPQADASFYISREDLHAVLTGQAKMADLVKAKKAKIIGNGAKLEEIIACLDNFDLWVNIVTPN
What is the function of this protein?
Alkylsulfatase that cleaves the widely used detergent sodium dodecyl sulfate (SDS).
What are the official names of this protein?
Linear primary-alkylsulfatase, Type III linear primary-alkylsulfatase.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RBFA_SALCH
Sequence: MAKEFGRPQRVAQEMQKEIALILQREIKDPRVGMMTTVSGVEMSRDLAYAKVFVTFLNDQDEAAVKNGIKALQEASGFIRSLLGKAMRLRIVPELTFFYDNSLVEGMRMSNLVTNVVKHDEERRVNPDDSKED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCAT1_MOUSE
Sequence: MKDCSNGCSAPFAGERGSEEVAETFRAKDLIITPATVLKEKPDPDSLVFGATFTDHMLTVEWSSASGWEKPHIKPFGNLPIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMDRMCRSAVRTTLPMFDKEELLKCILQLLQIDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPSKALLFVILSPVGPYFSSGSFTPVSLWANPKYIRAWKGGTGDCKMGGNYGASLLAQCEAVENGCQQVLWLYGKDNQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRQSILELAQQWGEFKVCERHLTMDDLATALEGNRVKEMFGSGTACVVCPVSDILYKGQMLHIPTMENGPKLASRILGKLTDIQYGRVESDWTIELP
What is the function of this protein?
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
What are the official names of this protein?
Branched-chain-amino-acid aminotransferase, cytosolic, BCAT(c), Protein ECA39.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.