PharMolix/UniProtQA huggingface dataset:
Protein: NUDK_SHIFL
Sequence: MTQQITLIKDKILSDNYFTLHNITYDLTRKDGEVIRHKREVYDRGNGATILLYNAKKKSVVLIRQFRVATWVNGNESGQLIETCAGLLDNDEPEVCIRKEAIEETGYEVGEVRKLFELYMSPGGVTELIHFFIAEYSDNQRANAGGGVEDEDIEVLELPFSQALEMIKTGEIRDGKTVLLLNYLQMSHLMD
What is the function of this protein?
Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.
What are the official names of this protein?
GDP-mannose pyrophosphatase, GDP-mannose hydrolase, GDPMK.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudK subfamily.
Protein: ZFAN6_HUMAN
Sequence: MAQETNHSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPATSVSSLSESLPVQCTDGSVPEAQSALDSTSSSMQPSPVSNQSLLSESVASSQLDSTSVDKAVPETEDVQASVSDTAQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI
What is the function of this protein?
Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis.  Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1.  Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6.  In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).
What are the official names of this protein?
AN1-type zinc finger protein 6, Associated with PRK1 protein, Zinc finger A20 domain-containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VERU3_PENPO
Sequence: MTNILRLFALVPGSVEQDAERISDRRDRSHEEGMTNPEAQSVLNDAEFGRVDPTGWFPHYKNCVQHFVDYSQHTPQVQSIAAFINIRLPCQRPSESSAPMSESTPSSFVSLRPYIRRLIVTAQDSPTVMQGFFGGDWEAGVGCIYKQERVNYMFTAKSSGWASTKAAYDISPDEETPFLRPLRDPSEDEIRVAEARWSEWLAMEDWMVGARSPW
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of the neurotoxin verrucosidin, a methylated alpha-pyrone polyketide that inhibits oxidative phosphorylation in mitochondria and thereby causes neurological diseases (PubMed:34093475).  The carbon backbone of verrucosidin is synthesized by the HR-PKS verA, and further modified by the other verrucodidin cluster enzymes (Probable).
What are the official names of this protein?
Verrucosidin biosynthesis cluster protein U3, Cluster 4 protein U3.
Protein: CML33_ARATH
Sequence: MNNMSLSDIFERFDTSKDGKISWEEFRDAIHALSPSIPSEKLVEMFIQLDTNGDGQVDAAKFASCMDQTAQSSGGDVEKELKDAFKLYDINCDGKISANELHVVMTRLGEKCTVESCVGMVQAIDVDGDGYIRFVGV
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML33, Calmodulin-like protein 33.
Protein: EFP_STRU0
Sequence: MIEASKLRAGMTFESEGKLIRVLEASHHKPGKGNTIMRMKLRDVRTGSTFDTTYRPDEKFEQAIIETVPAQYLYKMDDTAYFMNTETYDQYEIPVVNVEQELLYILENSDVKIQFYGSEVIGVTVPTTVELTVTETQPSIKGATVTGSGKPATLETGLVVNVPDFIEAGQKLVINTAEGTYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_SERP5
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKVGQTLLLHHVPNILSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNTYWKVRQAVETAKETLYTFDQLKSNKVEPRRPLRKMVFNVPTRRELTSGERAIQHGLAVSSGIKAAKDLGNMPPNICNAGYLASQARQLADAFSTNITTRVIGEQQMKELGMNAYLAVGAGSRNESLMSVMEYKGNPNPDAKPIVLVGKGLTFDAGGISIKPAEGMDEMKYDMCGAATVYGVMRVVAELNLPLNVIGVLAGCENMPGGSAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDTLTYVERFDPELVIDVATLTGACVIALGHHITGLMSNHNPLAHELIGASEQAGDRAWRLPMSDEYYEQLDSNFADMANIGGRPGGAITAACFLSRFTRKYSWAHLDIAGTAWRSGKAKGATGRPVALLSQFLLNRAGLNGDD
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_RUEPO
Sequence: MTLDLTLEDPRWTILPPLADRAISATLAQMGLDPELCEISLLGCDDARITALNAEFREKPSPTNVLSWPAEDLAAETPGGTPLAPEPDFTGAVPLGDIAIAFDTCQREADAAGKPIADHVTHLIVHGLLHLLGYDHIRDEDATLMEGLETRILGNLGIDDPYTME
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PARC_RICBR
Sequence: MKEAKIENIDFGSALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLRLEPNSGYKKCARVVGDVIGKYHPHGDVAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRYTESRMTEICTLLMEDIDKDTVDFRSTYDDSDLEPVIMPASFPNLLANGSEGIAVGMATNIPPHNLHELCDALMHLIDHPKAEISDIMNFIKGPDFPTGGIIIDKSDVITSAYMTGRGSFRVRARWEKEELNYGVYQIVVTEIPYQVQKSKLIEQIAILLKDKKIPLVSNIRDESTDIIRLVIEPRDRSCDPQIVMESLFKLTNLESRIQLNMNVIGSNNVPKVMNILEVLQEFLSHRQNIITRRSTYLLNKIKHRLEILEGLRIAYLNLDEIIKIIREEDEPKAIMMQRFQLTEIQVEAILNTRLRSLRKLEEQEIITEHSNLQKQQAILEEILNNPKELWKVVKKEIKAVQAKFGLNTTIGARRTSFEQVTLTNQVVDITAFITKEPITIICSKMGWVRSLKGHNNDLSSIKYKEGDAEKFILEAYTTDKILIISSEGRFFTLLADNISKGKGTGESIKLLVDIGNNDITEILVYKPDHLLLLASSIGKGFVVNSNEVMAQTKSGKQIMNVPDGHTCIACLPVNGDSVACIGESRKLLVFNIDEIPEMKKGQGVTLQKFKNAKLLDIKIFNREDGLSWNSGGKVKLEKNIIAFLGKRGSTGKLPPMGFPKNNRFS
What is the function of this protein?
Topoisomerase IV is essential for chromosome segregation.  It relaxes supercoiled DNA.  Performs the decatenation events required during the replication of a circular DNA molecule.
What are the official names of this protein?
DNA topoisomerase 4 subunit A, Topoisomerase IV subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS18_BURM7
Sequence: MARPTGKKFDKRRQQQNPLFKRKKFCRFTAAGVEQIDYKDTETLKDFIGENGKITPARLTGTKAHYQRQLDTAIKRARFLALLPYTDQHKA
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: UBP36_DROAN
Sequence: MPVSVAVCETTNVVNAALRESLGVGIGSGGASSDDKSAGEDTNSLQNHIVANAKRILMTKIEYEEVPNYQEAVLENLKSKYIVIKPTNPTNGCNLNGNTANTFGNKNNAGKIVGANGHDNNGRKLSDHPNQNHNHANPNGHHANPNELPKPKRVLYPRENIRIGWKQSERKWQVGSGMINAGNTCYLNSTLQALFHIPALANWLVSEQAHMENCNVSESGSFCIICAMAKTLQATQTTQSAVRPFLIYTKLKQICKHMIVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKSDSLEEAFEGYFSREKLEDFGYKCEGCKKKVSATKQFRLERAPITLCIQLKRFSMMGNKLTKQITFKPRIDLSKFAARSPAASVQPLIYRLVSMVTHLGVSQHCGHYTAIGSTEAGSYYNFDDSYVRPIAIQSVCNTNAYIMFYELDPLQTSSPAAARANGLRLTNGHGPVPVAVPATVSSPLPSPAKFIGPQLPPGGINGYSNGHGPKTTIQFKPQHQPSHQQNGVQQSAKSPLLSTHVKVEAAAGAAALAASAAPTANGNKSSSNHSNHKSVNQQHYLPISSEDEDSEDEVKARPTVQLPSMPKMDDCMDSGKPKSPVKTPVKTPLKSLVPYESASEEEEVVPLPNPNARKRSSDSSDSEHEPTTSSVQLNGHSKTNGSLSNGSSKSTDAIDEIFKSLKGYQAKKKSADSEDDDDDEDEPNNQLTNGWHPQKQSQSQSRSGPPSPKTPPSPAVIKSKTGIWKVTRDDGDDDEDDDDDDDEVVEEARAVRTPVKNHRNPFASSKTATDSPTTPGAKRQKLLNGSAIKTQQQPRAGNGYQSEATANGGTVNELLKQSHRGYSSSVLSWNGKPAELEKEPFVLVCAKRIAGHGSLDGSGSGSNTDIIDTEIPAAAVNFPSGSCSFSLLADARDQRQRDLADDEENEMDRGRQRKVKSGSAKISNSTPGYNPFMEFENQKRWHKNGGGGGFPRFYQNQNFRQGFQQRNKFKFNRFGGPGSAKFQQQRALQRHLAAGGGFTRRQPTHSAQQQQQQQS
What is the function of this protein?
Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells.  May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4).  Controls selective autophagy activation by ubiquitinated proteins.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 36, Deubiquitinating enzyme 36, Protein scrawny, Ubiquitin thioesterase 36, Ubiquitin-specific-processing protease 36.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SPIKE_FIPV
Sequence: MIVLVTCLLLLCSYHTVLSTTNNECIQVNVTQLAGNENLIRDFLFSNFKEEGSVVVGGYYPTEVWYNCSRTARTTAFQYFNNIHAFYFVMEAMENSTGNARGKPLLFHVHGEPVSVIISAYRDDVQQRPLLKHGLVCITKNRHINYEQFTSNQWNSTCTGADRKIPFSVIPTDNGTKIYGLEWNDDFVTAYISGRSYHLNINTNWFNNVTLLYSRSSTATWEYSAAYAYQGVSNFTYYKLNNTNGLKTYELCEDYEHCTGYATNVFAPTSGGYIPDGFSFNNWFLLTNSSTFVSGRFVTNQPLLINCLWPVPSFGVAAQEFCFEGAQFSQCNGVSLNNTVDVIRFNLNFTADVQSGMGATVFSLNTTGGVILEISCYSDTVSESSSYSYGEIPFGITDGPRYCYVLYNGTALKYLGTLPPSVKEIAISKWGHFYINGYNFFSTFPIGCISFNLTTGVSGAFWTIAYTSYTEALVQVENTAIKNVTYCNSHINNIKCSQLTANLNNGFYPVASSEVGFVNKSVVLLPSFFTYTAVNITIDLGMKLSGYGQPIASTLSNITLPMQDNNTDVYCIRSNQFSVYVHSTCKSSLWDNIFNQDCTDVLEATAVIKTGTCPFSFDKLNNYLTFNKFCLSLSPVGANCKFDVAARTRTNEQVVRSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRTGVGIIRRTNSTLLSGLYYTSLSGDLLGFKNVSDGVIYSVTPCDVSAQAAVIDGAIVGAMTSINSELLGLTHWTTTPNFYYYSIYNYTSERTRGTAIDSNDVDCEPVITYSNIGVCKNGALVFINVTHSDGDVQPISTGNVTIPTNFTISVQVEYMQVYTTPVSIDCARYVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEVDSMLFVSENALKLASVEAFNSTENLDPIYKEWPSIGGSWLGGLKDILPSHNSKRKYGSAIEDLLFDKVVTSGLGTVDEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANADKMTMYTASLAGGITLGALGGGAVAIPFAVAVQARLNYVALQTDVLNKNQQILANAFNQAIGNITQAFGKVNDAIHQTSQGLATVAKALAKVQDVVNTQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLTALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCGNGTHLFSLANAAPNGMIFFHTVLLPTAYETVTAWSGICASDGDRTFGLVVKDVQLTLFRNLDDKFYLTPRTMYQPRVATSSDFVQIEGCDVLFVNATVIDLPSIIPDYIDINQTVQDILENYRPNWTVPEFTLDIFNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKWPWYVWLLIGLVVVFCIPLLLFCCFSTGCCGCIGCLGSCCHSICSRRQFENYEPIEKVHVH
What is the function of this protein?
S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection.  Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion.  S2 region belongs to the class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the alphacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly.
Protein: RESF1_MOUSE
Sequence: MNWNTKQENVPKPPPYSKTQSSILQHFLMTSTTSQSSFNYSPHNQEASQTSFNYSLHNQEACMYSGNSNSVSQPLLSGRNYITPQTQISVSNMPTRTIVASQSSMERVVSTNGKGPQQPNHNLQTVSSGIMQNVWLPSHTEATISHNPDGGTNMPYMHPPQNQLVTSDTYSMQLQMAPLHSGKVPMTHQGSQGLNHFIPDQLVDWTQYTSNELSYPEYRPPPKQYSYILPATTSLQVKNNQLPTYTQSLQSKHSVPLSSHQYAAEASKRLSALPYSCRYENQHVQNAQPVSKHLPMEVPQSSEVHSSEKKKDTYRGFKQQWQNPNEKVSIGQFSEVKINIKQPYSESVRPSGDGVQALVQNNQEKRKYTYNPNTNQVIDTNATKEKLVRDIKSLVEIKKKFSELARKIKINKSLLMAAGCSKTANTSYTEPIQHSEFSAKEMSAKNGNDCSMELLATCLSLWKNQPSKTTEENVPKPLEEKQCNTSRISTTVVGSANPTNEVHVKSLCSGVGNSQKMMSSSQTVLPVLIPSCESSGVAVGKGTELQIAVVSPLVLSDTNTLPGKDSVPEVLPETLYPVVKEGSVCSLQTQPTETVALPFDVIGAVASNNISAEIPLPVDKEKQHKPIQGDPDIADSSLGKHSPLGTEVLPKPMDSTIVSGPMLQIESICSLAEGDVSYNSQIAEIFNSVQTEPQKPSPNQVIDSQQEQVYDTTENKDFSLQKDKCVQCTDVPHEVPEQPEPLQPEEPASSEYVEANREATEESCREYTGRKESTAKDVCLPAAIQQDPHPRETDMFSKSDHSLPAINEINDESEPISYLHDQLSELLKEFPYGIETFNRHEVSLDQQKTHKIVENQTGGKTSNVSGDSTDQIKITVLNSEQIKELFPEDDQPCDKLAEPENKEIVAEVKSPCDSQIPREESHDLGMLDPEKDKIHCCALGWLSMVYEGVPQCHCSSTEKKEKDQCLDINSSKQGEQPCNSGITIFEINPVSNNSKTPLTQATEEGHFSAVHGEKTKASKTKDNREGQELACHFSAKCYKKDKKGNFKIRHDTSLKMEQKLKNISSKCDIPNPSKCNKIAAPEILHVTTSNSAKNMPFSKQASQESLQKKHTSQDLGPVKAPIELSSNTDPCRSNTSSVQSVSPEKKKLKFKAGGSRLKYFEKRKTDHVIIPDVEIKKKKYEKQEQNKNAGDTLKLCSILTESNERASVQEKTVPSPESSDPKGSSSKSTRVITVQEYLQRQKDKQITGNNASRNICVETVLCDSGHTKTSKHSAAVSWGKLVEGQSISAETAKELEHNSSSHGKDFKIHHSEASRTHSVSNNNKGKFDGKQPDKMFKNKTSMNNESNQMPLQVKEQRKQYLNRVAFKCTERESICLTKLDSASKKLSIEKKSGEYTSKTKDTDKPSMLEFKLCPDVLLKNTSTVDKQDCPGPGPEKEQAPVQVSGIKSTKEDWLKCIPTRTKMPESSQRDSADSRLSKRSLSADEFEILQNPVKESNIMFRTYKKMYLEKRSRSLGSSPVK
What is the function of this protein?
Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1.  Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells.
What are the official names of this protein?
Retroelement silencing factor 1.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes around gamma-tubulin during M phase.
Protein: GCST_PROA2
Sequence: MKKTALYAWHEAAGAKIIDFGGYLMPVQYSGIIAEHTCVRTSAGLFDVSHMGNFMVKGRGAKAFLQHMTSNDVDKLSDGQAQYTLLLYPEGGIVDDLIIYRIDADTWFMVVNASNMEKDYSWLQEHLGSFEGVQLENHTEELSLIALQGPRSMEILDRVFTGGECSGIKPFHFRTVPFNGREVIVAATGYTGERGVEISVPNDAATALWVALMEAGSADGIQPIGLGARDTLRLEMGYPLYGHEINRETSPIEARLKWVTRLDKGNFVGRESCVAVDINPQRTVVGFMMHERAIPRQGFTVYNRDRKPLGSVCSGTMSPTLKQPIGTADVPRGYMKSGTPLYLEVRGKFYKGEVVKLPFVNRA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: ZRAS_ECO57
Sequence: MRFMQRSKDSLAKWLSAILPVVIVGLVGLFAVTVIRDYGRETAAARQTLLEKGSVLIRALESGSRVGMGMRMHHAQQQALLEEMAGQPGVRWFAVTDEQGTIVMHSNSGMVGKQLYSPQEMQQLHPGDEEVWRRIDSADGEPVLEIYRQFQPMFAAGMHRMRHMQQYAATPQAIFIAFDASNIVSAEDREQRNTLIILFALATVLLASVLSFFWYRRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTHLALQAVDLNTLINHSLQLVSQDANCREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASLEGKGARFTLWLPVNITRKDPQG
What is the function of this protein?
Member of the two-component regulatory system ZraS/ZraR.  May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium (By similarity).
What are the official names of this protein?
Sensor protein ZraS.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UXUA2_HALH5
Sequence: MRLTMRWFGPSDKVKLEYIKQIPGMKGIVSAIYDVAVGGVWPKEKILALKNNIERHGLTLDVIESVPVHEDIKLGKPTRDRYIENYKQTLRHLAECGIDTVCYNFMPVFDWTRSQLDFKLEDGSEALIYEEDVISRTNPLSGELELPGWDTSYENESLKGVLQAYKKISEEDLWDHLTYFVQAIMPVADEVGIKMAIHPDDPPWSIFGLPRIVTNKANLERLLSLYDSPNHGITMCSGSLGANEANDLPEMIRHFGGQGRIHFAHARNIKRTGPRSFQESAHLSEAGSVNMVAMLKAYHDIGFTGPLRPDHGRMIWGEKGRPGYGLYDRALGATYLNGIWEAVSS
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase 2, D-mannonate hydro-lyase 2.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: ICAB_STAAS
Sequence: MKYRKFIILVLSILIILPVSTLDGHHIANADDDSPKKLKYKENSALALNYHRVRKANFLNNFIYFFSSSKEIKNYSVSQSQFESQIKWLKSHDAKFLTLKEFLYYKKKGKFPKRSVWINFDDMDETIYENAYPILKKYKIPATGFIITGHVGEENFHNLDMISKKELKEMYKTGLWEFETHTHDLHNLSKNNKSKLMKASEATIIKDLNKSEKYLTKNFKKSQKTIAYPYGLMNDDKLPVIKKAGLKYGFSLEEKAVTPNSNDYYIPRILISDDAFEHLIKRWDGFHEKD
What is the function of this protein?
Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide.  N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions (By similarity).
What are the official names of this protein?
Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase, PNAG N-deacetylase, Poly-beta-1,6-GlcNAc N-deacetylase, Biofilm polysaccharide intercellular adhesin deacetylase, Biofilm PIA deacetylase, Intercellular adhesion protein B.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Attached to the cell surface.
Protein: TPIS_SHESR
Sequence: MALRRPMVAGNWKMNGSAALAQELFKKFASKLQNDSAEVVLCPPSIYLESVRQLLEANKEALDGSLVRMGAQNLSQHDFGAYTGEVSGQMLKDCGCRYVIIGHSERRRMYGETSNIVAEKFAAAQKHGLTPILCVGESGPAREARRTFEVIAEELDIVIQKNGTMAFDNAIIAYEPLWAVGTGKSATPEQAQEVHAFIRKRLSEVSPFIGENIRILYGGSVTPSNAADLFAQPDVDGGLIGGASLNSTEFLSLCTIAMSA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_BURA4
Sequence: MRVAEVVRNTSETQIRVKLDLDGTGRQKLATGVPFLDHMLDQIARHGLIDLEVEAHGDTHIDDHHTVEDVGITLGQAVAKAIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGINAHHQLETVFKAFGRALRAAVELDERAAGQIPSTKGSL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA_CROS8
Sequence: MIKKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVFGVYDGYLGLYEDRMIQLDRYSVSDMINRGGTFLGSARFPEFREEHIRAVAIENMKKRGIDALVVIGGDGSYMGAKRLTEMGFPCIGLPGTIDNDVAGTDYTIGYFTALHTVVEAIDRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFIVLPEVEFNREDLVAEIKAGIAKGKKHAIVAITEHICDIDELAKYIETETKRETRATVLGHIQRGGSPVPYDRILASRMGAYAIELLLQGHGGRCVGIQNEKMVHHDIIDAIENMKRPFKGDWLECAKKLY
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_LACP7
Sequence: MKSFMASPATIERKWYVVDATGHTLGRLSSEIAKVLRGKNKAIYTPHIDTGDYVIVVNADKIKVTGKKMDQKIYFSHSDYPGGVRETTLKEMLAKKPEDVITLAVKGMLPKGPLGRSMLNKLHVYAGPEHNNAAQKPEVLEIKY
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RL16_DESAL
Sequence: MLSPKKVKHRKVQKGRMQGVARRGGVLNFGQFGLQALECGFVTNRQIEAARIAMTRHVKRGGKIWIRIFPDKPFTKKPAEVRMGKGKGAPEGWVAVIKPGRILYEMDGVSYELAAEALRLAAHKLPIKTKIVARS
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: DDL_RHOOB
Sequence: MSKPRTRVAVIFGGRSNEHSVSCVSAGSVLRNLDPERYEVVPIGITTEGSWVLGSTDPESLSIRGRSLPSVDADGSALALTADPTRSGDLVALDDGEAGKILASVDVVFPVLHGAYGEDGTIQGLLELAGVPYVGPGVLASAAGMDKEFTKKLLAAEGLPIGFQVVLRPGTATLTDEQRSRLHLPVFVKPARGGSSIGITRVAEWAALDDAIAHARRHDPKVIVESGIAGREVECGVLEFPDGDVRASVIAEIRMPEGADDDEAFYDFDSKYLDDVCEFDVPAKLEDSVSDEIRALAVRAFSALDCQGLARVDFFVTEDGPVINEINTMPGFTSISMYPRMWDAVGVDYGTLVSTLVDTALARGTGLR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PV22_POMCA
Sequence: MVKKIHFIMERHASIVAFLLAVLALTESQAFTSVKLPRDEHWPYNYVSIGPAGVWAVNRQNKLFYRTGTYGDNANMGSGWQFKQDGVGQVDVGKDKVGYINLSGGSLFRIDGISQGNPVGGSPKSWEWWTKYIGMSLREDTRFSSRIENQNKVLTFTFRTCFWASRITNWCFADSSYTETVTAGGSGTWITKSQLKYKSGTFGNPDTEGGDWITVDSGSFQHVSSGSGVVLAVRSNGELVKRTGITCSLPQGSGWTSMLNGMSRVDTYGTVAWAVDTYGDLYFINL
What is the function of this protein?
The egg defensive protein perivitellin-2 is a pore-forming two-subunit glycoprotein that affects both the nervous and digestive systems of mammals (PubMed:23737950, PubMed:18640143).  In addition, it is a source of both structural and energetic molecules during embryonic development (Probable).  The tachylectin subunit (31 kDa) binds target membranes while the MACPF subunit (67 kDa) disrupts lipid bilayers forming large pores altering the plasma membrance conductance (PubMed:23737950).  Both in vivo and in vitro, the protein shows wide pH range stability and is resistant to enzymatic proteolysis from gastrointestinal environments (PubMed:23737950).  It specifically binds mature enterocytes but does not cause cell disruption on caco-2 (human colorectal adenocarcinoma cells) or rat intestinal cells (PubMed:23737950).  After oral administration to mice, it binds enterocytes and induces large dose-dependent morphological changes on their small intestine mucosa, reducing the absorptive surface (By similarity).  Additionally, it is detected in the Peyer's patches where it activates lymphoid follicles and triggers apoptosis (By similarity).  The toxin can also traverse the intestinal barrier and induce oral adaptive immunity with evidence of circulating antibody response (PubMed:23737950).  The toxin also shows hemagglutination properties thanks to the tachylectin subunit, but does not show hemolytic activity (PubMed:23737950).  In addition to enterotoxin activity, the toxin also acts as a neurotoxin, since an intraperitoneal injection induces paralysis of the mice rear limbs, followed by death (PubMed:23737950).
What are the official names of this protein?
Perivitellin-2 31 kDa subunit, PcPV2 31 kDa subunit, PcPV2-31, PV2 tachylectin subunit.
What is the protein family that this protein belongs to?
Belongs to the tectonin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.