Protein: MACA_PENTR
Sequence: MITSTSSTEVLTPANGSDDSKGTTTPATSSGDPEMHDDLLRNDTHDDVAIIGMACRVPGDVNSPSALWQFLLEKGDASGDMPTWRWDPYRQRHPRNAAVLAETTAKGYFLNDIDQFDAAFFAISPREAEQMDPQQRIALEVAWEALENAGISPSRLAGSNTSVYMGVNSDDYAKLVLEDLPDVGAHMGVGTAYCGIPSRISYLLDLMGPSVAMDAACASSLVAVHHARQAIRAGETDLAIAGGVNALLGPGLTRVLDEAGAISADGKCRSFDDSASGYGRGEGAGVVILKRLDKALTDGDQVLAVLKGSAVASDGKTLGIMAPNAQAQLLVAQKALKEAKVTSDSINYIEAHATSTSLGDPTETNALAEVYGVGSGRHPSDPCYIGSIKPNIGHLEAGAGVMGLIKAVLVLRYGEVPPQANLQTLNSKIAWKENLLRPARELVTLPRGALSRPLRAAIASYGYSGTVSHAIIEAFAGQSLFAERLAQIPDSDAAPALLLLSVPQANRISTTAAGLSRWLRDMDGAVSLATVASTLSQRRMHHRFRHAIVADSVANAIATLDDLAKDVPSRWAISDRIGSEAGKGAVWVFSGHGAQWPDMGRELFHSSPAFGEVVRNLEPIIQAELGFSAIETLHAGCPDRTDLIQAMTFLMHLGIAAVLEAESGPPTAVVGHSLGEAAAAVVSGALTWHEAALVVCRRARLYREFMGQGAMALVRLSASEARARIATHPGASVAIETSPTACVVSGTVDALQRLSEQWLEEGVEVRAVATDVPFHTPLLEKLAGPLRGALKNELHPQVPHRALYSTSLLDPRSDLLRDAEYWVMNMIQPVLLQSTVAALVDDGFRAFVEVASHPIITHSIVETISEQTTDRFIATPTMVRKQPALKSILAAVGRLHCFGCAVKPTDLDPTVPWSSSVPGTIWHHQSFYRAVSGMTAAQLASTHKPAANDLLGTRTALWGTEEVLYQTRLEEDNRPFPGRHPLHGSEIVPAAVLLRTFLRALSPRSVEEVSLQVPVVVSPAREIQIRHNTRNITITSRLEESTSNEHNSWLVNTTATVGADATPSVSHVDIAEVAKRLPQKLSDSFSIDYLASVGVSAMGFPWRVAHHVASDNEMLARVHANPDSLPGMDDLLTSVMDAATSIASTLWHSKPRLRMPTAVRRVVAVGVATPQVVYIHCTKAQSSVDEADVIISSEEGMVLMEIQGMAFAGVEGESLSRKSTSGLVHQISWPPAALAEEPLEFAHIAFLTADATKAQVGTYQRQIEGRGISTSIHERASDLPLTTHSSMAVVYLPQFTDRIFDTATRSCNDLVTAAQVILSSSDKPTIRLFAVTSESNLGHSALTGLGRILHTEHPEIWGSLIDLEDPSVFPLMAMRYVRNADVIKIEDGVPRTARLRPLRPAPPHSTAGPATLTFSPASTYLITGGLGSLGISVAQWMVTQGARRILLLSRRSLPPRSIWTASHKPGTQFIIDSILSLERLGATIHPVAIDISHPSAVTNLRSALTTLSLPPVAGVVHAAGILRDQLIEQITPDAFEAVLAPKIAGALALHTVFPPSSPDLDFFVLFSSCGQLLGFPGQASYASGNSFLDALARSRRKEGDNAISLLWTSWRGMGMGASSNGALEAELYARGITDVTPDEAFLAWSSISGTEGADHGVVLRARPLESGEPLPHAILRDIAPRKEKAVGEGNGENEEQRKKLSGKELAEYVLVVVKKCVSTTLSIPEDEVDETVALPEMGMDSVMTVNFRMSLQQTLTVSVGPTLVWKYPTVHHLVEYFCQVLDE
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of macrophorins, isoprenoid epoxycyclohexenones containing cyclized drimane moieties (PubMed:28926261).  The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the polyketide synthase macA (PubMed:28926261).  6-MSA is then converted to m-cresol by the decarboxylase macB (By similarity).  The cytochrome P450 monooxygenase macC then catalyzes the oxidation of m-cresol to toluquinol (By similarity).  Epoxidation of toluquinol is then performed by the short chain dehydrogenase macD, with the help of macE, and a further prenylation by macG leads to 7-deacetoxyyanuthone A (By similarity).  The next step is the hydroxylation of C-22 of 7-deacetoxyyanuthone A by the cytochrome P450 monooxygenase macH to yield 22-deacetylyanuthone A (By similarity).  O-Mevalon transferase macI then attaches mevalon to the hydroxyl group of 22-deacetylyanuthone A to produce yanuthone E (By similarity).  The terpene cyclase macJ catalyzes the cyclization of 22-deacetylyanuthone A to macrophorin A (PubMed:28926261).  MacJ is also able to catalyze cyclization of yanuthone E and 7-deacetoxyyanuthone A to their corresponding macrophorins (PubMed:28926261).  The macJ products can be further modified by macH and macJ, as well as by the FAD-dependent monooxygenase macF, to produce additional macrophorins, including 4'-oxomacrophorin A, 4'-oxomacrophorin D and 4'-oxomacrophorin E (PubMed:28926261).
What are the official names of this protein?
6-methylsalicylic acid synthase, 6MSAS, Macrophorins biosynthesis cluster protein A, Non-reducing polyketide synthase macA.