PharMolix/UniProtQA huggingface dataset:
Protein: ABCA6_HUMAN
Sequence: MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMAPQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLENLPYAMGIIFNETFSYKLIFFQGYNSPLWKEDFSAHCWDGYGEFSCTLTKYWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMRWKLLPHSDEP
What is the function of this protein?
Probable transporter which may play a role in macrophage lipid transport and homeostasis.
What are the official names of this protein?
ATP-binding cassette sub-family A member 6.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCA family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: LPXK_VIBVY
Sequence: MIEKIWFENHPVKYLLWPLLWPLSLLFGAISRRQKAAYQRGAKASFQASIPVIVVGNITAGGNGKTPVVIWLVEKLQQLGFKPGVVSRGYGAKAPVYPMVVDSESLTSHCGDEPKLIFERTGALVAVDPIRPNAVKRLIELGANIIVTDDGLQHYALQRDIEVVVVDGQRRFGNQQLIPLGPLREPTSRLQNVDFIITNGGDAHQGEIAMSLMPDMAVNLMTGEKVAVNELASLVAFAGIGHPPRFFKTLEQLGADVVVSQGFADHQDFDPEAIAKLAHQGKNVIMTEKDAVKCRRFAQNNWWYLPVSAQFSSHDQQRILQRITEVVKEYGSSTA
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: GPMI_NITOC
Sequence: MSTPPRPLALLILDGWGYSEETASNAIHAAHTPIWDTLWDRYPHTIIRASGAEVGLPNEQMGNSEVGHLNLGSGRVIYQEYTRVNRALRTGSFFTNHTLTEAVDRAVKSDKAIHILGLLSPSGIHCHEDHIHAMVELAIKRRCQEVYLHAFLDGRDTAPKSAQASILAMQAKFTELGKGRFASLIGRYYGMDRDHRWPRIQAAYNLIATGQAEYEAESAKQALAMAYERGETDEFVQATRIVPSGKAPVQVKDGDVIIFMNFRSDRARQITRAFIEPDFTGFERLYWPKLAQFVSLTEYSKEFDIPVAFPSEKPQNTFGQVLAKLGLHQLRIAETEKYAHVTFFFNGGREQPFEGEDRILIPSPQVDTYDQKPEMSAVEVTDNIVKAIESDKYDVIICNYANPDMVGHTGDFNATVKAIETIDQCLGRVWAALQSAGGELIITADHGNAEKMYNAQYQQPHTAHTHNAVPFIFVSERAAIASANGSLADVTPTMLYLMNIKPPPEMSEHRLIELSSP
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: DADD_META3
Sequence: MILIQDATINNKVQDILIEKNKIKKIGKNLIQKENLNRKDLKIIDGKNKIIIPGLVNTHTHTPMTLFRGVADDLPLMDWLNNYIWKMEANLNEKIVYDATMLGCMEMIKSGTTTFNDMYFYMNGIIKGVQETGIRAYLGYGMIDLFDEEKRENELKETVNTVENIQKLNNPKINPTVSPHAPYTCSMELLQESHNLAKKYNVPLHIHLNETIDEIKTVEEMTNKRPFEYLDSFGFFNGVKVISAHNVHLSNKEIEIIKNKNIAISHNPISNLKLASGIAPIPKLMENTVLITLGTDGCGSNNNLNLFEEIKMASLIHKGNSLNPTVVSASQSFEFATKNGANALGLNAGELVEGALADVVIIDINKPYLIPNENIYSHLVYSFNGVVDMVIIDGEIVLNNGKMVNINEEKVYENAEKSYNKLLNNSDE
What is the function of this protein?
Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs.  Can also deaminate adenosine.  The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated.  Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions.  May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
What are the official names of this protein?
5'-deoxyadenosine deaminase, 5'-dA deaminase, 5'-methylthioadenosine deaminase, MTA deaminase, Adenosine deaminase, S-adenosylhomocysteine deaminase, SAH deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
Protein: PTQA_ECOLI
Sequence: MMDLDNIPDTQTEAEELEEVVMGLIINSGQARSLAYAALKQAKQGDFAAAKAMMDQSRMALNEAHLVQTKLIEGDAGEGKMKVSLVLVHAQDHLMTSMLARELITELIELHEKLKA
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2) (PubMed:10913118, PubMed:10913117).  Also able to use N,N',N''-triacetyl chitotriose (GlcNAc3) (PubMed:10913117).
What are the official names of this protein?
PTS system N,N'-diacetylchitobiose-specific EIIA component, EIIA-Chb, EIII-Chb, IIIcel, N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMKL_XANC8
Sequence: MKFFASCAKGLEYLLADELLALGASKATATISGVNVEGALRDAQRAVLWSRLASRVLWPLTEFDCPDEDALYAGVAELPWHEHLSTGHTLSVDAHVSGTAITHARYAAQRIKDAVVDTIRRQGLERPSVDVESPDLRLNLSLRKGRATISVDLGGGPLHRRGWRMAQNEAPLKENLAAAVLLRAGWPRAYADGGGLLDPMCGSGTLLIEGALMAADVAPGLQRYGSDIPSRWRGFDRDSWQQLVTEARERDSVGRAALKQVIHGSDMDPHAIRAAKENAQVAGVAEAIWFGVREVGDLQTRPQATGVVVCNPPYDERLAADAALYRKLGDTLQRVVPQWRASLLCGNAELAYATGLRAGKKYQLFNGAIECALIVCDPIAVPRRTPLAAPTALSEGAQMVANRLRKNLQKFKKWRAREGIECFRVYDADLPEYSAAIDVYQQADGDRRIFLHVQEYAAPATIPEADVRRRLGELLAAAREVFEVPAERVALKSRERGKGGSKYGRFEQRNEIVNVREHGALLRVNLFDYLDTGLFLDHRPLRGTMAQQSKGRRFLNLFCYTGVASVQAAVAGASATTSVDLSGTYLQWCADNLALNGQAGSKHKLVQADALAWLEAERAHFDVIFCDPPTFSNSARAEDFDIQREHVRLLRAAVARLAPGGVLYFSNNFRRFKLDEEAVSEFAQCEEISPRTIDPDFERHARIHRAWRLTA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAM_PINTH
Sequence: MVELKFLIAFFLAFTAGILAIKLGQALYDC
What are the official names of this protein?
Photosystem I reaction center subunit XII, PSI-M.
What is the protein family that this protein belongs to?
Belongs to the PsaM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ISCS_PSEE4
Sequence: MKLPIYLDYSATTPVDPRVAQKMAECLLVDGNFGNPASRSHVFGWKAEEAVENGRRQVAELINADPREIVWTSGATESDNLALKGVAHFYQTKGKHIITSKIEHKAVLDTARQLEREGFEVTYLEPGEDGIVTPAMVEAALRDDTILVSLMHVNNEVGSINDIAAIGELTRSRGVLFHVDAAQSAGKVEIDVQKLKVDLMSFSAHKVYGPKGIGALYVSRKPRVRLEAIIHGGGHERGMRSGTLPTHQIVGMGEAFAIAKQEMAAENVRIKALSDRFFKQVSDLEELYVNGSQTARVPHNLNLSFNYVEGESLLMSLKDIAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFSFGRFTTEEEVDYAAQEVCKAVNKLRELSPLWDMYKDGVDISKIEWAAH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MECA1_BACSU
Sequence: MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEVMDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASEDLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENRYYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.  Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease.  When overexpressed, inhibits sporulation.  Also involved in Spx degradation by ClpC.
What are the official names of this protein?
Adapter protein MecA 1.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: ARTM_ECOLI
Sequence: MFEYLPELMKGLHTSLTLTVASLIVALILALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGPGQFPTLQEYPALWHLLSEPWLCALIALSLNSAAYTTQLFYGAIRAIPEGQWQSCSALGMSKKDTLAILLPYAFKRSLSSYSNEVVLVFKSTSLAYTITLMEVMGYSQLLYGRTYDVMVFGAAGIIYLVVNGLLTLMMRLIERKALAFERRN
What is the function of this protein?
Part of the ABC transporter complex ArtPIQMJ involved in arginine transport.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Arginine ABC transporter permease protein ArtM.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YVAM_VACCW
Sequence: MSEYFISRTSIWTVFMLPIMYGPIKSMIEISRSSYNVSVIVNTPIGVITNAASMAAYVNDLLLIHFLLSLVEFFNT
What are the official names of this protein?
Uncharacterized 8.6 kDa protein.
Protein: SYL_THEVO
Sequence: MDYSRCCGSTNSRVIYMNIDEKWQNAWERDHVFEPKIDERKKFMITVPWPYTNGSLHVGHGRTYTLGDIIARYKRSRNYNVLFPMGFHQSGTPILAFSERIRAGDASTIALYRSYLSEYGEKDIDGWLEKFKDPRNIADYFSNAIINDFKHLGYSIDWTRKFTSADEFYQNVVKWQFHKLNEKGLIKQDKYPILYSIDDDNAVGEDDIKDGDTDKVSVEEYTAVFFESNSYSLIAASLRPETLFGVTNIWINPTGEYVKIKIGDKIAVVSKEAVDKLKYQRNDVSVIGPISAESIQRKKFTTPFGKEVPVYKADFVDTDNGTGVVYSVPSHSVYDFVYYRRKKSGQTPVVIEAPLKMPEVEIKFDLNSKEGLDEATKELYKSEFYYGKLVNSGEYTGLTVRDAREKIKKDLIGSGKAIIFYETSRKAVTRGGSKVIVAVLPDQWFIDYSADWLKKLSHDMLNRMMIYPEMYRNVMNDAIDWLKERPCARRRGLGTKLPFDDRWVIESLSDSTIYPAVYTTSIQMRKLYENGKLDENAIERIFDGGEVQNDEERTARNEFSYWYPVDIRLTAVPHISNHLSFYVMNHAAIFPPEKWPSGLIISGLVVSNGAKISKSKGNVVSLLEITKKYSADIYRLYVAVQADVSSTMDWNENDLSNIVRRFNEFKTIMDSFKPDTSELNFEETWFVSRFAERLKQFMDQMDGFQIRDAYINIFYGTLNDLKYAVNRGASQNRSLASIIADWLRALMPVISHHAEEYWHRYVSNTYVSINPFDDNFAEKYERLAKVYGLSTSEFYQVMDYVEHIIQDINNIISVTGIEPKSVEITVANEDVIKASREFLSNSVSERSKRYLQYLAKRRKDIVVYPFNEIDILRRNSSYISRQVKADVSINTGDIINGKIAVPGKPVIHIT
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_STRPD
Sequence: MSRYTGPSWKQSRRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFSYGLGEKQFRNLFVQATKIKEGTLGFNFMVLLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSYRVDPGQVISVREKSMKVPAILEAVEATLGRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: CO155_CAEEL
Sequence: MEFEQRIKAYRFVAYSAVAFSVVAVLSVCITLPMVHNYVHHVKRTMNQEVQFCRGSAKDIWTEVNELKSIQHANRTARQSGYDAGVNGGSASTGGCDACCLPGAAGPAGTPGKPGRPGKPGAPGLPGNPGHPPQQPCDPITPPPCQPCPQGPPGPPGPPGPSGDAGGNGNPGSPGQDGQPGAPGNKGPSGPNGNPGAPGAPGQPGQDAPSEPITPGAPGPQGTPGPQGPPGQPGQPGHDGQPGAPGPKGPNGNPGQPGADGNPGAPGQSGTPGGVGEKGICPKYCAIDGGVFFEDGTRR
What is the function of this protein?
Nematode cuticles are composed largely of collagen-like proteins.  The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).
What are the official names of this protein?
Putative cuticle collagen 155.
What is the protein family that this protein belongs to?
Belongs to the cuticular collagen family.
Protein: ZN543_HUMAN
Sequence: MAASAQVSVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQLDHRQELWMATKDLSQSSYPGDNTKPKTTEPTFSHLALPEEVLLQEQLTQGASKNSQLGQSKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSERDGLGSDDGVCTKITQKQVSTEGDLYECDSHGPVTDALIREEKNSYKCEECGKVFKKNALLVQHERIHTQVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCMECGKAFNRRSHLTRHQRIHSGEKPYKCSECGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEKPYECIECGKAFNRRSYLTWHQQIHTGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRRSHLKQHQRIHTGEKPYECSECGKAFTHCSTFVLHKRTHTGEKPYECKECGKAFSDRADLIRHFSIHTGEKPYECVECGKAFNRSSHLTRHQQIHTGEKPYECIQCGKAFCRSANLIRHSIIHTGEKPYECSECGKAFNRGSSLTHHQRIHTGRNPTIVTDVGRPFMTAQTSVNIQELLLGKEFLNITTEENLW
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 543.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TCAL1_MACNE
Sequence: MDKPRKENEEEPQSAPKTDEERPPVEHSPEKQSLEEQSSEEQSSEEEFFPEELLPELLPEMLLSEERPPQEGLSRKDLFEGRPPMEQPPCGVGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIQAADELEEMKRVRNKLMIMHWKAKRSRPYPI
What is the function of this protein?
May be involved in transcriptional regulation.  Modulates various viral and cellular promoters in a promoter context-dependent manner.  Does not bind DNA directly (By similarity).
What are the official names of this protein?
Transcription elongation factor A protein-like 1, TCEA-like protein 1, Transcription elongation factor S-II protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family. TFA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SLED_CALRH
Sequence: CPLHWSSYNGYCYRVFSELKTWEDAESFCYAQHKGSRLASIHSREEEAFVGKLASQTLKYTSMWLGLNNPWKECKWEWSDDAKLDYKVWLRRPYCAVMVVKTDRIFWFNRGCEKTVSFVCKFYS
What is the function of this protein?
Potent inhibitor of collagen-induced platelet aggregation.  It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1).  The gamma/delta subunits mainly contribute to this activity.
What are the official names of this protein?
Snaclec rhodocetin subunit delta.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: NCAP_SABVB
Sequence: MSNSKEIPSFRWTQSLRRGLSEFTTPVKTDVLRDAKMILDGLDFNQVSLVQRILRKSKRNDGDLDKLRDLNKEVDNLMSMKSSQRDTILKLGDLNKSELMDLASDLEKLKRKVGQTERSASGGVYLGNLSQSQLTKRSDLLRKLGFQQQQVRSPGVVRIWDVADPNRLNNQFGSVPALTIACMTKQSDNTMGDVVQALTSLGLLYTVKFPNLIDLEKLTAEHDCLQIVTKDESGLNISGYNYSLSAAVKAGATLLDGGNMLETIRITPDNFSQIIKTTLSIKKKEGMFVDEKPGNRNPYENLLYKICLSGEGWPYIGSRSQIKGRSWENTTVDLSTKPQQGPRTPEKAGQNIRLSHLTELQESVVREAMGKIDPTLTTWIDIEGTSNDPVELALYQPDTGNYILCYRKPHDEKGFKNGSRHSHGMLLKDLESAQPGLLSYVIGLLPQNMVLTTQGSDDIRRLVDTHGRKDLKIVDIKLASEQARKFEEPIWSDFGHLCKKHNGVIVPKKKKDKDIPQSSEPHCALLDCLMFQSAIAGQPPQTKLEGLLPDALLFTLEAAFTI
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  The encapsidated genomic RNA is termed the nucleocapsid (NC).  Serves as template for viral transcription and replication.  The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses.  Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation.  Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: TRPB_NITMU
Sequence: MKVYDLPDSHGHFGPYGGIFVAETLISALEDLRIQYERYRSDADFQAEFAHELKHYVGRPTPIYHAKRWSAQLGGAQILLKREDLNHTGAHKINNAMGQALLARRMGKSRVIAETGAGQHGVATATVAARYGMECVIYMGSVDVERQAANVYRMKLLGAEVIPVESGSRTLKDALNEAMRDWVTNVADTFYIIGTVAGPHPYPMMVRDFQAIIGREAITQMQEDYGRQPDALIACVGGGSNAIGLFYPYLDSSIRMIGVEAAGHGVETDQHAATLTKGRPGVLHGNRTYLIQDENGQIVETHSISAGLDYPGVGPEHAWLKDSGRAEYFGITDEQALEAFHALCHYEGIIPALESSHALAYAARLAPALTSDKLLLVNLSGRGDKDMPTVARASHITF
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: PRP31_HUMAN
Sequence: MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKTIAKLWDSKMFAEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKSGLMST
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166).  Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543).
What are the official names of this protein?
U4/U6 small nuclear ribonucleoprotein Prp31, Pre-mRNA-processing factor 31, Serologically defined breast cancer antigen NY-BR-99, U4/U6 snRNP 61 kDa protein, Protein 61K, hPrp31.
What is the protein family that this protein belongs to?
Belongs to the PRP31 family.
Protein: RECO_ROSDO
Sequence: MEWREEGILLSTRRHGESAAIIEVFTPSHGRHAGVVRGGTSRKIAPILQPGAQLDLTWRARLEDHIGSFLVEPVRSRAAAAMGDRLALAGLNAVTALLGFCLPEREAHRPLYVETERLLDLLGEGEIWPLAYLRWEVQLLHDMGYALALEACAVTGQRDDLIYVSPKSGRAVSAKGAGDWADRLLPLPPILRGIGGGPDAEIAQAFITTGYFLTEHLARDLGGKPLPEARARFVETFSRRL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: SELK_RAT
Sequence: MVYISNGQVLDSRNQSPWRLSFITDFFWGIAEFVVFFFKTLLQQDVKKRRGYGGSSDSRYDDGRGPPGNPPRRMGRISHLRGPSPPPMAGGUGR
What is the function of this protein?
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity).  Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity).  Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity).  Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function.  Plays a role in protection of cells from ER stress-induced apoptosis.  Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).
What are the official names of this protein?
Selenoprotein K, SelK.
What is the protein family that this protein belongs to?
Belongs to the selenoprotein K family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single- pass membrane protein. Note=Probably mainly localized in the ER.
Protein: TSAD_DEIGD
Sequence: MTFPRYILGIDTSCDDTGVGVVELAPDGSVQVRANRVWSQTVHAQYGGVLPELASREHVERIDTVTGDALAEAGLTVGDLAAVAATSGPGLVGALLVGLMYGKGLAQALNVPFYAAHHLEGHIFAAASEADLQAPYLALVVSGGHTHLFDVPREGEYVLVGATRDDAAGEAFDKVARLAGLGYPGGPAISEAARRGDPEAVPFKEPLQGQKGFDFSFSGLKTAALLAHRAGAKPEDLAAGFERAAVRFLVGTTLRAARAYGRETVVVSGGVAANRALREAFAASPVRAVFPGKGLNTDNGAMIALAGAAAIRAGRAPSPLSEGAVAYAPLASV
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_BORBR
Sequence: MSFKPVVALVGRPNVGKSTLFNRLTRSRAALVADFSGLTRDRHYGEGRVGDTPFLVIDTGGFEPVAKDGILAEMARQTRQAIAEADVVVFLVDARAGVNAHDHEIARLLRKSGQQRVLLAVNKAEGMGVGNATGDFHELGLGEPHPISAAHGDGIVDLIEIALSGLVAPPADTGEQLEQDVVDHRIKLAIVGRPNVGKSTLINTLLGEERVIAFDMPGTTRDAIEIDFERDGRKYTLIDTAGLRKRGKVFEAIEKFSVIKTLQAIEASNVVLLMIDAQAEVSEQDAHIAGFVLETGRAVVVAINKWDGLDSDQRERIEREFQRKLRFLGFARMHTISALKGQGVKPLLKSVNAAHAAAFAKLSTPRLTRELQAAVEQQPPPRKGIFRPKMRYAHQGGQNPPLIVIHGNALDAVPDSYRRYLETRFRNAFDLAGTPLRIEFKSSRNPYVQEN
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.