PharMolix/UniProtQA huggingface dataset:
Protein: YBEY_MYCA9
Sequence: MSIEVVNESGIDVAEGELVSVARFAIAAMDVHPAAELSMMLVDLAAMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPSMLGDIVLCPQFAAEQAEAAGHSLAHELALLTVHGVLHLLGYDHAEPEEEREMFALQNQLLQDWYEQQAQLYRDSRLLDKSRNFDE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSGA_ONYPE
Sequence: MEKALVLRFLAGVYYIKDLETQIILEAKKRGKLKTPDIKTTQKENSSASDFIIKVGDIVFYELSCDTYLIQSILPRKNELKRPNVANIDQVLLVFSLVKPNFQFLLLDKFLLILEQQKLDVVLVFSKIDLLEPENLTTMQQQLSYYQKFQPFYYINSKQKIGIDALKHIFANQITVLAGQTGVGKSTLLKALIPDAKLKTQEISESLGRGKHTTKNAQLYEFNGGFIVDTPGFSKLDLTTFCPRTLKNFYPDFVEHVCDCFFGESCLHLQEEKCGVKKSLENGKILPSRYQNYVSFYEEIKNQLKY
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y986_DESVV
Sequence: MAGHSKWANIQHRKGRQDAKRGKMFTKAAKEIIIAAKAGGDPVGNSRLRAAIAAAKAINLPKDKIENAIKKGTGELAGGDILEMAYEGYGPGGVALIVEVATDNKNRTVAEVRHILSKHGGSMGESGCVAWMFDRKGVITLEKDKYTEEQLMEVALEAGAEDVTDEGESWEVVTAAADFNAVREALEAAGVEMQSAEFTMVPQNEIEVDVETGRKLMRLVDALEDNDDVQNVHANFDLPDELLAELG
What are the official names of this protein?
Probable transcriptional regulatory protein Dvul_0986.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH4_GEOSM
Sequence: MIKEYLKKPSLSDVQLTRDTRNIPIGKVGVKDISYPIVVMDKNKSFQNTIARINMYVDLPHHFKGTHMSRFVEILNEYREEIALDKLELILSTMKEKLGASNAHLEMEFPYFVEKTAPVSRAKSLMEYTCTFSASLSDRFDFVLGIKVPVTSLCPCSKELSSYGAHNQRSIMTVQVRYSEFIWIEDLIDIIEECGSSPVYSLLKREDEKFVTERAYENPRFVEDMVREATVRLLNMQNISWFSVEAENFESIHKHSAYAAIERSRES
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: MURG_CHLT2
Sequence: MKKINKIVLAVGGTGGHIIPALAARETFIHEDIEVLLLGKGLAHFLGDDSEIAYCDIPSGSPFSLRVNRMFSGAKQLYKGYVAALQKIRDFTPDLAIGFGSYHSLPAMLASIRSRIPLFLHEQNIVPGKVNKLFSRFAKGVGMSFAAAGEHFHCRAEEVFLPIRKLSEQIVFPGASPVICVVGGSQGAKILNDVVPKALARIRESYSNLYVHHIVGPKGDLQAVSQVYQDAGINHTVTAFDHNMLGVLQASDLVISRSGATMLNELLWVQVPAILIPYPGAYGHQEVNAKFFTHTVGGGTMILQKYLTEESLSKQVLLALDPATSENRRKAMLSAQQKKSFKSLYQFICESL
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACYLT_MYCTU
Sequence: MIAGLKGLKLPKDPRSSVTRTATDWAYAAGWMAVRALPEFAVRNAFDTGARYFARHGGPEQLRKNLARVLGVPPAAVPDPLMCASLESYGRYWREVFRLPTINHRKLARQLDRVIGGLDHLDAALAAGLGAVLALPHSGNWDMAGMWLVQRHGTFTTVAERLKPESLYQRFIDYRESLGFEVLPLSGGERPPFEVLSERLRNNRVVCLMAERDLTRTGVEVDFFGEPTRMPVGPAKLAVETGAALLPTHCWFEGRGWGFQVYPALDCTSGDVAAITQALADRFAQNIAAHPADWHMLQPQWLADLSESRRAQLRSR
What is the function of this protein?
Catalyzes the transfer of a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring linked to the 2-position of myo-inositol in phosphatidyl-myo-inositol monomannoside (PIM1) or dimannoside (PIM2) (PubMed:12851411).  Essential for growth and survival in axenic cultures and during macrophage infection and in a mouse model of infection (PubMed:33468587).
What are the official names of this protein?
Phosphatidylinositol mannoside acyltransferase, PIM acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LpxL/LpxM/LpxP family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Permanently associated with the membrane.
Protein: MSCL_CHRVO
Sequence: MSVLKEFKEFAVKGNVIDLAVGVVIGGAFGSIVKSLVDDVIMPPIGLLIGNVDFSNLFFVLKDGAKQAGPYVSVAAAKQAGATTLNLGLFINALVSFTIVAFAIFMLVKAINRLKREEAAPAPAAPATKECRYCLSAIPEKATRCPCCTSQLD
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROB_HAEIE
Sequence: MLCVNVELQERRYPILIGSGLLQDERSYPIKRGGRVMIVTNPTVAQFYLDTVIYALEKRGCVVDHVLLPDGEKYKTLESLNLIFTALLQGNHGRDTTIIALGGGVIGDVAGFAAASYQRGVRLIQIPTTLLSQVDSSVGGKTAVNHELGKNMIGAFYQPSMVIIDTLTLNTLPKREVNAGLAEVIKYGAILDYEFFEWLEQHIDELVALNPEALQHCISRCCQIKADVVARDETEKGDRALLNLGHTFGHAIETHLGYGNWLHGEAVSTGMMMAAALSEELGDISIADVSRLEKLLARANLPTVSPDTMQPEDYLPHMMRDKKVLSGKLRLVLLKSLGQAYVANDTAHTLVLNAIRRCTQTD
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CASL_MOUSE
Sequence: MWARNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPVQETPGHEQPTPGPMHQTFGQQKLYQVPNSQAASRDTIYQVPPSYQNQGIYQVPTGHGTPEQDVYQVPPSVQRNIGGTNGPLLSKKVITPVRTGHGYVYEYPSRYQKDVYDVPPSHSTQGVYDIPPSSVKGPVFSVPVGEIKPQGVYDIPPTQGVYAIPPSACRDEAGLREKEYDFPPPMKQDGKPDTRPEGVYDIPPTSTKTAGKDLHIKFPCDAPGGVEPMARRHQSFSLHHAPSQLGQSGDTQSDAYDVPRGVQFLEVPTETSEKANPEERDGVYDVPLHNPADAKGSRDVVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPSQDKRLRLDPDTAIEKLYRLQQTLEMGVCSLMSLVTTDWRCYGYMERHINEIRTAVDKVELFLREYLHFAKGALANASCLPELVLHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTISTYAETLFRADPANSHLKNGPNSIMNSSEYTHPGSQMQPLHPGDYKAQVHSKPLPPSLSKDQPPDCGSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQSKAQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNNSVGAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQDIRNKVRNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
What is the function of this protein?
Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (By similarity).  As a focal adhesion protein, plays a role in embryonic fibroblast migration (PubMed:25059660).  May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells.  Integrin beta-1 stimulation leads to recruitment of various proteins including CRKl and SHPTP2 to the tyrosine phosphorylated form (By similarity).  Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:16148091, PubMed:17174122).  Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (PubMed:27359298).  Negatively regulates cilia outgrowth in polarized cysts (By similarity).  Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity).  Positively regulates RANKL-induced osteoclastogenesis (PubMed:27336669).  Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (PubMed:26683084).
What are the official names of this protein?
Enhancer of filamentation 1, mEF1, CRK-associated substrate-related protein, CAS-L, Neural precursor cell expressed developmentally down-regulated protein 9, NEDD-9, p105.
What is the protein family that this protein belongs to?
Belongs to the CAS family.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Nucleus. Cytoplasm, cytoskeleton. Note=Localizes to both the cell nucleus and the cell periphery.
Protein: HNRDL_XENTR
Sequence: MTGFGATPDFNEGSKINASKNQQDEGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAVSVDKVLETKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPETTEEQIKQYFGGFGEIENIELPMDTKTNERRGFCFVTYTGEEPVKKLLESRFHQIGTGKCEIKVAQPKEVYRQQQQKQQKGGRGAATGRGGARGRGRGQGWNQGYSNYYDQNYGSYGNNGSYADQGYNNSYSGYDYSGYNYGSYGYNQGYTDYSGQQSTYGKARGGGNHQNNYQPY
What is the function of this protein?
Acts as a transcriptional regulator.  Binds DNA and RNA (By similarity).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein D-like, hnRNP D-like, hnRNP DL.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner.
Protein: BRK6_PHYSG
Sequence: APPGFTPFRIA
What is the function of this protein?
Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity).  May target bradykinin receptors (BDKRB).
What are the official names of this protein?
[Ala1,Thr6,Ala11]-phyllokinin.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPA2_BURMA
Sequence: MTPTPDAPAAADAATGAGWLARRRGALARVALAPIAQAIGRVERVADGIAFVSGLEDTMLNEVLRFEGGVTGFAHTLDEDLISVVLLDPDAGVRAQTAVARTGAVLEVPAGPQLLGRVVDPLGRPLDGGAPLDAAHTLPIERAAPAIIERDLVSEPLDTGVLIVDALFTIGRGQRELIIGDRATGKTSLAIDAIVNQRHSDVICVYVAIGQRASAVRRVIDAVRRYGAPERCVFVVAPAACAPGLQWIAPFAGFSIAEYFRDRGQHALVVVDDLTKHAATHRELALLTREPPGREAYPGDIFYVHARLLERAAKLSAALGGGSLSALPIAETDAGNLAAYIPTNLISITDGQIVLDSALFAANQRPAVDVGLSVSRVGGKAQHPALRAASGRLRLDYAQFLELEAFTRFGGLTDARLRAQITRGERIRALITQPRFRALRTLDEVVLLKALAAGTLDAMSPDLVAPLRERLPAWLDARIAALTPALAPPRDWLADDAALDALAESVGELIERIAADAARRATAGMPAEDAAGDIGGAFGGEQARGDADRDADHGANREVSREVSPEASREVSREVSREVSHEADRDAAADAARVAGRAPGRAEPDRAVPRAMPDGPPRAQADGDRASASRPPPDARGDAARTAPSPQGGADANVNADANVDAEAEARHKR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 2, ATP synthase F1 sector subunit alpha 2, F-ATPase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BACH2_HUMAN
Sequence: MSVDEKPDSPMYVYESTVHCTNILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKNDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNSEDGLFVCRKDAACQRPHEDCENSAGEEEDEEEETMDSETAKMACPRDQMLPEPISFEAAAIPVAEKEEALLPEPDVPTDTKESSEKDALTQYPRYKKYQLACTKNVYNASSHSTSGFASTFREDNSSNSLKPGLARGQIKSEPPSEENEEESITLCLSGDEPDAKDRAGDVEMDRKQPSPAPTPTAPAGAACLERSRSVASPSCLRSLFSITKSVELSGLPSTSQQHFARSPACPFDKGITQGDLKTDYTPFTGNYGQPHVGQKEVSNFTMGSPLRGPGLEALCKQEGELDRRSVIFSSSACDQVSTSVHSYSGVSSLDKDLSEPVPKGLWVGAGQSLPSSQAYSHGGLMADHLPGRMRPNTSCPVPIKVCPRSPPLETRTRTSSSCSSYSYAEDGSGGSPCSLPLCEFSSSPCSQGARFLATEHQEPGLMGDGMYNQVRPQIKCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQITDLPRNDFQMMIKMHKLTSEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNQLKACMGELLDNFSCLSQEVCRDIQSPEQIQALHRYCPVLRPMDLPTASSINPAPLGAEQNIAASQCAVGENVPCCLEPGAAPPGPPWAPSNTSENCTSGRRLEGTDPGTFSERGPPLEPRSQTVTVDFCQEMTDKCTTDEQPRKDYT
What is the function of this protein?
Transcriptional regulator that acts as repressor or activator (By similarity).  Binds to Maf recognition elements (MARE) (By similarity).  Plays an important role in coordinating transcription activation and repression by MAFK (By similarity).  Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862).  Positively regulates the nuclear import of actin (By similarity).  Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713).
What are the official names of this protein?
Transcription regulator protein BACH2, BTB and CNC homolog 2.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. CNC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation.
Protein: CYSI_SALNS
Sequence: MSEKHPGPLVVEGKLSDAERMKLESNYLRGTIAEDLNDGLTGGFKGDNFLLIRFHGMYQQDDRDIRAERAAQKLEPRHAMLLRCRLPGGVITTTQWQAIDKFAADNTIYGSIRLTNRQTFQFHGILKKNVKPVHQMLHSVGLDALATANDMNRNVLCTSNPYESQLHAEAYEWAKKISEHLLPRTRAYAEIWLDQEKVATTDEEPILGATYLPRKFKTTVVIPPQNDIDLHANDMNFVAIAENGKLVGFNLLVGGGLSIEHGNKKTYARTASEFGYLPLEHTLAVAEAVVTTQRDWGNRTDRKNAKTKYTLERVGVDTFKEEVERRAGIKFEPIRPYEFTGRGDRIGWVKGIDDKWHLTLFIENGRILDYPGRPLKTGLLEIAKIHQGEFRITANQNLIIASVPESQKAKIETLARDHGLMNAVSAQRENSMACVSFPTCPLAMAEAERFLPSFTDKVEAILEKHGIPDEHIVMRVTGCPNGCGRAMLAEIGLVGKAPGRYNLHLGGNRIGSRIPRMYKENITEPDILASLDELIGRWAKEREAGEGFGDFTVRAGIIRPVLDPARDFWE
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: PVK2_PERSS
Sequence: GSSGLISMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, PerSc-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PROA_AGRVS
Sequence: MLDTVAKADGIDALMLDIGAKAKAAARPLAIASADQKNAALMAMSEAILSGKSQIIAANAIDLKAAETAGLAASFIDRLTLNEERITAMAKGLREVAELKDPVSEVIAAWERPNGLKIERVRTPLGVIGVIYESRPNVTADAGALCLKSGNAVILRGGSDSVNSSRAIHACLVAGLVAAGLPDHAIQLVPVTDRAAVGAMLTGLNGTIDVIVPRGGKSLVARVQSDARVPVFAHLEGLCHVYVDGSADLDMAKSIVVNAKMRRTGICGSAETLLVDSAAIGSHLMPLLEALTEAGCEIRASATVLKVFPGLKAAVDEDWRTEYLDAIISVAVVDGIGGAIDHIARYSSNHTEAVIAEDPAVVERFFNEVDSAILLHNASTQFADGGEFGMGGEIGIATGKMHARGPVGVEQLTSFKYRVHGTGQIRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPHE_ECOLI
Sequence: MFTATEAVPVAKVVAGNKRYPGVVALDNVNFTLNKGEVRALLGKNGAGKSTLIRMLTGSERPDSGDIWIGETRLEGDEATLTRRAAELGVRAVYQELSLVEGLTVAENLCLGQWPRRNGMIDYLQMAQDAQRCLQALGVDVSPEQLVSTLSPAQKQLVEIARVMKGEPRVVILDEPTSSLASAEVELVISAVKKMSALGVAVIYVSHRMEEIRRIASCATVMRDGQVAGDVMLENTSTHHIVSLMLGRDHVDIAPVAPQEIVDQAVLEVRALRHKPKLEDISFTLRRGEVLGIAGLLGAGRSELLKAIVGLEEYEQGEIVINGEKITRPDYGDMLKRGIGYTPENRKEAGIIPWLGVDENTVLTNRQKISANGVLQWSTIRRLTEEVMQRMTVKAASSETPIGTLSGGNQQKVVIGRWVYAASQILLLDEPTRGVDIEAKQQIYRIVRELAAEGKSVVFISSEVEELPLVCDRILLLQHGTFSQEFHAPVNVDELMSAILSVH
What is the function of this protein?
Probably part of a binding-protein-dependent transport system YphDEF.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YphE.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: YPI1_CANGA
Sequence: MNQVSEGSRTVSVEEMPRVLQLRAANTNITEGESTSQSRNVRWEEDVVDNENMNKKKTKICCIFHPAQEEEDPEQLCPSDHEHSSSSSSSSSSESDDDDKYNSEQRRQRRIERRRRRQKTNRPASPNAYEIQPDYSEYRKRMNANV
What is the function of this protein?
Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.
What are the official names of this protein?
Type 1 phosphatases regulator YPI1.
What is the protein family that this protein belongs to?
Belongs to the YPI1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: APT_FRACC
Sequence: MTSIDDAPQRSAAHDAVAEVLRGHIRDIPDWPQPGVVFKDITPLLATPTAFGVVIGALADAARALGATTIAGIEARGFLLAAPVADRLGTGLVPIRKQGKLPGPTRSASYDLEYGAATIEIHADAVHDGDRVLLVDDVLATGGTAAAAHSLLAAGGGEVVGLAVLMELSFLPGRDRVAPLDVVSLLTI
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PKSH_BACSU
Sequence: MDLVTYQTIKVRFQASVCYITFHRPEANNTINDTLIEECLQVLNQCETSTVTVVVLEGLPEVFCFGADFQEIYQEMKRGRKQASSQEPLYDLWMKLQTGPYVTISHVRGKVNAGGLGFVSATDIAIADQTASFSLSELLFGLYPACVLPFLIRRIGRQKAHYMTLMTKPISVQEASEWGLIDAFDAESDVLLRKHLLRLRRLNKKGIAHYKQFMSSLDHQVSRAKATALTANQDMFSDPQNQMGIIRYVETGQFPWEDQ
What is the function of this protein?
Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.  Probably catalyzes the dehydration of the (S)-3-hydroxy-3-methylglutaryl group attached to PksL.
What are the official names of this protein?
Probable polyketide biosynthesis enoyl-CoA hydratase PksH.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_CLOBJ
Sequence: MKKEEIIQAIKEMTVLELNELVEACEEEFGVSAAAPVAVAGAGAAAGAGAAEEKTEFDVVLADAGSEKIKVIKAVREVTGLGLKEAKALVDGAPKTLKEAASKEDGEAIKAKLEEVGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: CDD_YERPA
Sequence: MQARFHTSWAELPASLQFALEPILSAENFPAMLTAEQVKTVKNISGLDDDALAFALLPLATACALTPISHFNVGAIARGKSGNFYFGANMEFRGVPLQQTIHAEQCAVTHAWLRGETNLVAITVNYTPCGHCRQFMNELNSGSELHIHLPGRPPSTLGQYLPDSFGPTDLAITTLLMDPVNHGYTLAETDPLTQAALNAANHSHAPYSQSHSGVALETTNGKIYAGRYAENAAFNPSLPPLQAALILANITGENCASIRRAVLVEGHNAVTSQWDTTLATLNALGCSAVKRVTF
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: BZPJ_DICDI
Sequence: MVELESMSSSSEWFLNNNSNIHNNTHNHNHNNNNNNNNINSNNHGHSANSSAHNHNNNNNNNTNNNSNNSNNNNNNNNNNNNTQNTNNGTFLTPLPVLTNSSTGLGKSIDWLYTNTSNTDSHNINSSSNKVTKLSNGFSLLNQDGTQSPSCFLNLSSTGNHEDPVQVPMNNNPQDLLFQFNISPQLQSQNNNSSNNNNNNNNNGSNTPLNGSNGSNNNYSSPISPVPQYQHSAGSSPIQEYPYYSPSSSPHSNESTSPITVIKDSGSIINPINNNNNNNNNNNNNNNNNNNNNNNNNNKNNLNNNTFQFSSLKSTTGIAPPLQTDYHLLYNFVQQNFSGKPEDSLLNQTLNNNNNNNNNNNNNNNNTTIQTSPQPLVLPQIQNPFLPYNISTPISVPNNILSSAQSSTNSSPNNNNNNNNNNNNIFSTVNNNNNLVNNNSNNMELDVDKPFSQEKFYLHLKSIVPSFNENFEASSESAQSESSQESDYDALNERNSGVKKRGRDEDQIDTSGQVVLSREHVLKLSSKEIEEYVSRLKMHHILTQAEEKELKKQRRLVKNREYASQSRSRRKIYVENIETKLQKTNQDCASIKSQLNSVKEENKALKKQLYSLTNTLKSNPSLAEAFGKIFSPIGNNKTSSATLFVFFFLFTFTFLFQSSTVTFNSDRVSSIQRNLLSLEETQATEWNIKRAILEETKQYVDSLLTSLYTSKLQSLSETPLDTSNYIINNNNNESTSETTTNNKVVSTSSDDISNVLSNLSVSDKEVPQKCKDSSDLKCDSPPLSPLN
What is the function of this protein?
Probable transcriptional regulator.
What are the official names of this protein?
Probable basic-leucine zipper transcription factor J, Developmental gene 1037 protein.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SMO_RAT
Sequence: MAAGRPVRGPELAPRRLLQLLLLVLLGGRGRGAALSGNVTGPGPRSAGGSARRNAPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHSKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGLAFELNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANLWLVEAEISPELEKRLGRKKKRRKRKKEVCPLGPAPELHHSAPVPATSAVPRLPQLPRQKCLVAANAWGTGEPCRQGAWTVVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLMEAELLDADSDF
What is the function of this protein?
G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling.  Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched.  When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes.  Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia.  Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.
What are the official names of this protein?
Protein smoothened.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, cilium.
Protein: COAX_CHLP8
Sequence: MQSSRSVSTEAFVRLVVDIGNTTTTLAVFTGETEPSVESVQSTLFGEPKAVAELFLSLAHRHGTPQAVAVCSVVPAAAASCSAQLESLFSVPVVTIAASLRLPFQLDYATPHTFGADRIALCAWSRHLFGDCPVIAVDIGTAITFDVLDAEGNYRGGLIMPGIDMMAGALNSRTAQLPLVDIDKPESLLGRSTIECIRNGIFWGAVRQIAGLIDAIGAELPGESKAAPAEVLVTGGNSRIIAPEIASITHLDELAVLRGIDLLLRLNS
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_PSEU2
Sequence: MSNHDQKRDEGYIEKLVQVNRVAKTVKGGRIFTFTALTVVGDGKGRVGFGRGKSREVPAAIQKAMEAARRNMIQVDLNGTTLQYAMKSAHGASKVYMQPASEGTGIIAGGAMRAVLEVAGVQNVLAKCYGSTNPVNVVHATFKGLKGMQSPESIAAKRGKRVEEII
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.