PharMolix/UniProtQA huggingface dataset:
Protein: IF3_STRT1
Sequence: MRIIAKKDLFINDEIRVREVRLVGLDGEQMGIKPLSEAQAIADDANVDLVLIQPQATPPVAKIMNYGKFKFEYQKKRKEQRKKQSVVTVKEVRLSPVIDKGDFETKLRNGRKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEKTQDIAIIEQRAKMDGRQMFMQLAPIPDKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_THEVB
Sequence: MARVKRGNVARKRRKKILKLAKGYRAGHSKLFRTANQVVMKALCNAYRDRRRRKRDFRRLWIARINAAARQYGMSYSQLMGALKKADIQLNRKMLAQLAVLDAPAFATVIQTARAL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RUVC_PSEAE
Sequence: MTLILGIDPGSRITGFGVVRETARGCEYVASGCIRTGNGPLHERLHVVFRSVREVIRTHGPTALSIEQVFMARNADSALKLGQARGAAIVAAMEEGLSVAEYTASQVKQAVVGTGGADKQQVQMMVMHLLKLTQKPQIDASDALAIALCHAHTQQSLVPHGLVGARRRGGRLRL
What is the function of this protein?
Complements an E. coli deletion mutant (PubMed:8982068).  A C-terminally truncated protein (residues 1-153) binds cruciform but not linear dsDNA, the consensus cleavage sequence is 5'-TT|C-3' (PubMed:32085896).
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: EIF3C_USTMA
Sequence: MSGFFRKVGDSDSESDISSSEEELSELESGDEQPKTTQPAASRSRFLKGSDDDSDSDDDDSDDDDQDSLDSDDDNGERRTDGKKAPTSRFMKGAADSDDSDSEEEVKKVVKSAKDKRIDDMQTIVNHIESAQKSSDWTSINKDFDNLMRSIERQRTLNEQIPAFFYKAISQLDQYLNESAAKEKDAKKKMKAPVAKAMNGMKQKLKKVIKENDETIARYRSDPEGFEAAAEAALSAAAAPADAETAIAKGKKERLAAALDSDANDDFQTVGRGGRTETFTSEGLFKSLTAIMEARGKKSTDKNEQIRKLHDLSGVADSPYKKIRVILALVAARFDYNASATAYMPVEMWDSARKEINEIVALLGKNRSYVVREETEDYDDEVERVPGQNGEKDVVAVRGSIISFVDRLDDEFTKSLQNIDPHTTEYVDRLCDEKKLYETIVLAQGYFESQSETEALSRCTMRRLDHVYAKQDVIIKALESTLGEAAKTFESKLFPSAVRVAEQDGPAVLVRALCTYLYQARGVQAERPRTRAVLCHIYFHALHADYHVARDMFLMSHLQDAIQLADVATQILYNRVVVQIGICAFRNGLIKESQVALQEIFATGRVKELLAQGVQKQNQFSTVTPEQEKLERQRQLPFHMHINLELLECIYLISSMLLEVPNMALAGNDPELRKRVISRPFRRMLDYTDRQVFSGPPENTRDHIMQACKALQNGDCKACIELISDIKIWKLMPGSQEVKLMLAKRIQEVGLRTYLFSYSAYYESVSLSHLAATFDVEETVVKAMVSKMIYNDELAASLDPSANVVSFHRLELTKVQQLAATLAEKANSMLEQNERLLDAKLGEGKEQRSGAGGERGDREGGQPGGRRERRGGSAARGRGRGRGRAQQFQALGQKV
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 93 kDa subunit homolog, eIF3 p93, Translation initiation factor eIF3, p93 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_HALS3
Sequence: MPQPNRPRKGSMGFSPRKRAESEVPRFNSWPADDGEVGLQGFAGYKAGMTHVVLVDDKANAPTEGMETTVPVTVVETPPMRAAAVRLYEDTPYGKKPLTEVWADDTHESLDRTLSVPDEGGDTDELIEALDTEEIADIRVITHTVPGDTAGVPKKNPDVMETRVGGGTLADRLEFAADLIEDGGVHAFGDVFRAGEFTDAAGITKGKGTQGPVKRWGVQKRKGKHARQGWRRRIGNLGPWNPSRVRSTVPQQGQTGYHQRTELNKRLIDINDGDEPTPDGGFPNYGEVDGPYTLVKGSVPGPEQRLVRFRPAVRPNESPRLDPEVRYVSTASNQG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: BRE1B_PONAB
Sequence: MSGPSNKRAAGDGGSGPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLPMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAARARTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERPKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLWAQASGSTHSTPNLGHPEDSGLSAPAPGKEEGGPGPVSTPDSRKEMAPVPGTTTTTTSVKKEELVPSEEDVQGLTPGAQGPSSRGRESEARPKRELREREGPSLGPPPVASALSRADREKAKVEEAKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYIS
What is the function of this protein?
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1).  H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively).  It thereby plays a central role in histone code and gene regulation.  The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory.  Required for transcriptional activation of Hox genes.
What are the official names of this protein?
E3 ubiquitin-protein ligase BRE1B, BRE1-B, RING finger protein 40, RING-type E3 ubiquitin transferase BRE1B.
What is the protein family that this protein belongs to?
Belongs to the BRE1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZHD9_ORYSJ
Sequence: MEAMDVKYKPLVFPNGAIKKAAKPAAVAPAVGGGGGGETVYRECLKNHAASLGGHALDGCGEFMPSPAANPADPTSLRCAACGCHRNFHRRLPEGSPPPPPPPALLPAPPMPPHRGEETPEVRLPGVDGDESDSDSDGSEYDDERSVSPPPPPLAAAVAHQVYYPSAPHMLLSLGSSGQAQRLPPQVMSPAAAAAPPPGGGGGGMPRKRFRTKFTAEQKQRMQELSERLGWRLQKRDEAIVDEWCRDIGVGKGVFKVWMHNNKHNYLGGHSARRSASSSSAAAAAAPPFNPPTSPPPPPPPPPHATDFNINGTATAATAAAAATIAAGNHQENGASSPQSA
What is the function of this protein?
Putative transcription factor.
What are the official names of this protein?
Zinc-finger homeodomain protein 9, OsZHD9.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYS_PSEA7
Sequence: MLDPKLVRTQPQEVAARLATRGFQLDVARIEALEEQRKSVQTRTEQLQAERNARSKAIGQAKQRGEDIAPLLADVDRMGSELEEGKRQLDAIQGELDSMLLGIPNLPHESVPVGADEDANVEVRRWGMPKTFDFEVKDHVALGERHGWLDFETAAKLSGARFALMRGPIARLHRALAQFMINLHTAEHGYEEAYTPYLVQAPALQGTGQLPKFEEDLFKIGRDGEADLYLIPTAEVSLTNIVSGQILDARQLPLKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVDPATSYEALEGLTANAERVLQLLELPYRVLALCTGDMGFGATKTYDLEVWVPSQDKYREISSCSNCGDFQARRMQARYRNPETGKPELVHTLNGSGLAVGRTLVAVLENYQQADGSIRVPDVLKPYMGGIEVIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL95_HCMVM
Sequence: MMAAAVVRAEVRRQRREERKKMASARTTEDPPENHVVADVACGTGAVTRSSSSSLVVSSSSASGSDESSSASPLSFPVSSPSTAVRSPGSAGVSTSLCSVERMVELSAQSPAADFSVSEAWRFEEAVNMALVACEAVSPYDRFRLIETPDENFLLVTNVIPRESAEVPVLDSSSSGGDSGPEDKKKNVGNKTAGEKNGGGSRAKRRRRRRAPKNDAATPSFLRRHDVLERFAAAAEPLPSLCVHDYALRNADRVTYDGELIYGSYLLYRKAHVELSLSSNKVQHVEAVLRQVYTPGLLDHHNVCDVEALLWLLYCGPRSFCARDTCFGREKNGCPFPALLPKLFYEPVRDYMTYMNLAELYVFVWYRGYEFPAPTPQATTAGGGGGGGSGGGGGAGACAVETSASAGRVDDAGDEVHLPLKPVSLDRLREVLQAVRGRFSGREVPAWPASSRTCLLCALYSQNRLCLDLARDEARTVSYSPIVIQDCAAAVTDVTLSHILPGQSTVSLFPVYHVGKLLDALSLNDAGLITLNL
What is the function of this protein?
Participates in the expression of late viral mRNAs.  Expressed before viral DNA replication, UL95 assembles at the viral pre-replication complexes (pre-RCs) containing the early viral protein UL44.
What are the official names of this protein?
Protein UL95.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL95 family.
What are the subcellular locations of this protein?
Host nucleus. Note=Recruited to nuclear replication compartments.
Protein: PA2H1_BOTJR
Sequence: MRTLWIMAVLLVGVEGSLFELGKMILQETGKNPAKSYGAYGCNCGVLGRGKPKDATDRCCYVHKCCYKKLTGCDPKKDRYSYSWKDKTIVCGENNPCLKELCECDKAVAICLRENLGTYNKKYRYHLKPFCKKADPC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks enzymatic activity.  Shows local myotoxic activity (PubMed:11018293, PubMed:12079495, PubMed:31906173).  Induces inflammation, since it induces edema and leukocytes infiltration (PubMed:11018293, PubMed:31906173).  In addition, it induces NLRP3 NLRP3, ASC (PYCARD), caspase-1 (CASP1), and IL-1beta (IL1B) gene expression in the gastrocnemius muscle, showing that it is able to activate NLRP3 inflammasome (PubMed:31906173).  It also damages artificial and myoblast membranes by a calcium-independent mechanism, has bactericidal activity, and induces neuromuscular blockade (PubMed:27531710).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (PubMed:27531710) (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (PubMed:27531710) (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (PubMed:27531710) (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (PubMed:27531710) (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (PubMed:27531710) (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog bothropstoxin-I, Bothropstoxin I, BthTx-I, BtxtxI, svPLA2 homolog, BOJU-I, Myotoxic phospholipase A2-like, Phospholipase A2 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SAHH_HALWC
Sequence: MSAYSPLSAQLDADTDVDVESTRTEGRRKMEWTLQHMPILQELRARFAETKPLAGETIGMAMHVEAKTANLVELLALGGAEVAITGCNPLSTHDDVSAALDSNENVTSYAKRGVDEEAYYDAIEAVVAHEPTITIDDGMDMVYAIHEDHPDLLDTIIGGAEETTTGVHRLRAMDEDDELQYPVFAVNDTPMKRLFDNVHGTGESALATIAMTTNLSYAGKNVVVAGYGYCGKGVAQKAAGQNANVIVTEVEPRRALEAHMEGYEVMPMNEAATRGDVFVTTTGNRDVITQEDFEVMSDGAILANAGHFDVEINLEELSELAIDTYEARDGVQAYELADGRRLNVLAEGRLVNLAAPIALGHPAEVMDQSFGIQAVCVRELIENKSSYDAGVHNVPDELDREVAEIKLEAEGVDIDSLTQTQSEYLDSWSHGT
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_CHLAB
Sequence: MHLHEYQAKDLLTSYAIPMPPYRVASSVEEGRHTLNELGINAGVVKVQVHAGGRGKNGGVIVAKSPEEILAAVDQLLHMRFVSNQTSGEALPVEKVLITPLVNIAAEYYLAVIMDRKNRCPTIMLSKAGGVDIEEVAQKYPDQQLTISLTPFARLYNYQLRQMIKFMGWEGDTGKQGVQMIKNLVQCFYDNDASLLEINPLVRTQEGDLLVLDAKVTIDDNALYRHPKLEVLYDPSQENVRDVLAKQIGLSYIALDGNIGCLVNGAGLAMSTLDILKIHGGSAANFLDVGGSATEQQIQEAVSLVLSDENVEVLFINIFGGIMDCSAVASGLVAVMQTRENLIPTVVRLEGTNVELGKEIVQCSGIPCKFTDSLNTGAQLAVALSK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: SSU72_CANGA
Sequence: MDQKQALKFCTVCASNNNRSMESHRILQEAGYEVSSYGTGSAVRLPGLSFDKPNVYPFGTPYNDIYNDLLSQSAERYKANGLLQMLDRNRRLKKAPEKWQEGTKTFDFVFTCEERCFDAVCEDLMNRGGRLNKIVHVINIDIRDDNENAKIGGRAILELANMLNEKVSECEQNDTLFEDCILDILTKWQEAHPQLPCLYAPSYY
What is the function of this protein?
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.  SSU72 is required for 3'-end formation of snoRNAs (By similarity).
What are the official names of this protein?
RNA polymerase II subunit A C-terminal domain phosphatase SSU72, CTD phosphatase SSU72, Suppressor of SUA7 protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the SSU72 phosphatase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y3153_STUS1
Sequence: MPSFDVVSELDKHEVTNAIDNAIKELDRRYDLRGKGSFEQKDLTVQLTAEAEFQLEQMLEILKLSLVKRKIDIQCLEVKDAYASGKTMKQEAVLREGIDKELAKKIVAHIKDAKLKVQAAIQGEQVRVTGKKRDDLQEAIALLRGHEFGMPLQFNNFRD
What are the official names of this protein?
UPF0234 protein PST_3153.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: G6PI_BORAP
Sequence: MINYKNLNELENFKILERIDPEVLKTVLTGKRIKEYDITIEGDSVHYNYASKQINENHLKIFQNLSDEANLIEKYKEILNGERVNISENRKVLHHLTRGQIGKDVIEDNKENMREFFQSELEKIYNFAKQIHSGNIKSANGKKFKNVVQIGIGGSSLGPKALYSSIKNYAKKHNLALMNGYFISNIDPDESAEVLNSINIDETLFIIVSKSGNTLETKANMQFLINKLKSNGIKEYKKQMVIITLKNSMLALEEKGYLEYFFMHDSIGGRFSPTSAVGLVLLALCFTEKIVKEILKGANKADKKSLNKNVKDNAPLLAALISIYERNVLNYSSNCIIAYSKAMENFYLHLQQLEMESNGKSVNRFNETINYKTVRIIWGGIGTDVQHSFFQMLHQGTDIVPMDFIGFNETQLKEDVISDNSSSNDKLKANLIAQIIAFSKGKENSNKNKNFKGERPSALIYSKELTPYAIGSILSHYENKVMFEGFLLNINSFDQEGVQLGKTLANQILKNDTFEDEAIESYSKKILKQD
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBC_CYAPA
Sequence: METLFNSSVAVSGRDQQSTGFAWWSGNARLINLSGKLLGAHVAHAGLIVFWTGAMTLFEVAHFIPEKPMYEQGLILLPHLATLGWGVGPGGEVIDVYPYFVVGVLHLVSSAVLGFGGLYHAIIGPEVLEESFPFFGYDWKDKNKMTTIIGIHLILLGSGALLLVLKAMFFGGVYDTWAPGGGDVRVISNPTLNPTVIFSYITKSPWGGDGWIVSVDNMEDIIGGHIWLAFICIIGGVWHILTKPFSWARRALVWSGEAYLSYSLAALALMGFIANCFVWFNNTAYPSEFFGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPSGEIIFGGETMRFWDTRAPWLEPLRGANGLDLTKIKYDIQPWQERRAAEYMTHAPLGSLNSVGGVATEINSVNYVSPRSWLSTSHFVLGFFLFIGHLWHAGRARAASGGFEKGLDRENEPVLSMKLLD
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, cyanelle thylakoid membrane; Multi-pass membrane protein.
Protein: RN217_MOUSE
Sequence: MGEEQSTVSGSGGARASGGGSAGQPESPRPRGDRVRTAGPRAAASSSRPNGGGGGRDPGCVDASVQEPASNRAPAGQPARLPLSGPLDPQSLELQLEREAEGAGPREAPPGQQPPDGLLLDVLAQRHPPPAKPQVLCSVYCVESDLPEAPSAESPSPSESPPQAPLGPIPASPPPSFPSSPLSLPADPLSPDGGSIELEFYLAPEPFSVPGLLGAPPYSGLGGVGDPYAPLMVLMCRVCLEDKPIKPLPCCKKAVCEECLKIYLSSQVQLGQVEIKCPVTECFEFLEETTVVYNLTHEDSIKYKYFLELGRIDSSTKPCPQCKHFTTFKKKGHIPTPSRSESRYKIQCPTCQLIWCFKCHSPWHEGVNCKEYKKGDKLLRHWASEIEHGQRNAQKCPKCKIHIQRTEGCDHMTCSQCNTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLILVLGLALGAIAVVIGLFVFPIYCLCKKQRKRSRTGMHW
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF217, IBR domain-containing protein 1, RING finger protein 217.
What is the protein family that this protein belongs to?
Belongs to the RBR family. RNF217 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Cytoplasm.
Protein: RL6_SACEN
Sequence: MSRIGKLPITVPSGVEVTIDGQDVTVKGPKGSLVQRIAEPITVEKDDDGAILVKRPDDERNSRSLHGLSRSLVNNMVVGVSQGYQKDLEIHGVGYRVQQKGSNLEFALGYSHPVVVEPPEGIEFATDGPTKLSVKGIDKQLVGEIAARIRKLRRPDPYKGKGVRYAGENIRRKVGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SIG21_CRISI
Sequence: IIGHLIKTALGMLGL
What is the function of this protein?
Has antibacterial activity against a wide spectrum of Gram-positive bacteria including B. cereus (MIC=25 uM), E. faecalis (MIC=100 uM), L. lactis (MIC=12 uM), L. innocua (MIC=50 uM), M. luteus (MIC=25 uM), S. aureus (MIC=12 uM), S. epidermidis (MIC=25 uM) and S. uberis (MIC=25 uM).  Lacks antibacterial activity against the Gram-negative bacteria E. cloacae and E. coli.  Inhibits the formation of NO by neuronal nitric oxide synthase with an IC(50) of 12. 4 uM.
What are the official names of this protein?
Signiferin-2.1.
What are the subcellular locations of this protein?
Secreted.
Protein: RL31B_ACIBC
Sequence: MRKDIHPAYQQVLFHDTNADVYFLIGSTIQTKQTKEYQGQVYPYVTLDISSASHPFYTGEVRQASNEGRVASFNKRFARFNRKS
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: SELO_CLOBJ
Sequence: MKERKVIIKTGLNLENSYTSLPEIFFTRQSPSCIPSPKLAVLNYPLITSLGLNAQVLQSADGVDILAGNKIPEEAIPIAQAYAGHQFGHFTMLGDGRALLLGEHITPLGDRFDIQLKGSGKTPYSRGGDGKAALGPMLREYIISEAMNALGIPTTRSLAVVTTGESIMREAELPGAILTRVAASHIRVGTFEYVSRWGTVEELRALANYTLQRHFKKGYDKENPYLFLLQEVIEKQAELIAKWQLVGFVHGVMNTDNMTISGETIDYGPCAFMDVYDPETVFSSIDIYGRYAYGNQPNIATWNLARFAETLLPLLHINPNEAIKIAENAVSDFTKLYKNNWLSGMRAKLGIFNEELEDEYLIEDLLSIMHKYGADYTNTFRALTFDNIEDTVLFDKMEFDKWYKLWQERLTRQEEAKLSSKQLMKSSNPSVIPRNHRVEEALEAAVKEGDYSVMEKLLDALSKPYDHSKEQDYYSKLPEPSTCPYQTYCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: Y5938_BACC0
Sequence: MSTILVLGGSNGRTLEKLAKKRDCQVIFHDGKNHGGVKKTFRSVIKKCDVIVVQKGACGHVSIDVAKEYAKKYDVPLLFNQGFGGTGALEIGLKHLQAA
What are the official names of this protein?
UPF0751 protein BCAH820_B0138.
What is the protein family that this protein belongs to?
Belongs to the UPF0751 family.
Protein: BRK3_PITHY
Sequence: RPPGFTPF
What is the function of this protein?
Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity).  May target bradykinin receptors (BDKRB).
What are the official names of this protein?
Des-Arg9-[Thr6]-bradykinin, Des-Arg-[Thr6]-bradykinin.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: IF2_DEHMB
Sequence: MVEKTSKPSAKTEVAPPVKIIELGAAVSVKELADSLETNPVEVIKALMRKGIMANINQVIDFDIAKGVIEAAGFEAKLKILKKSAAKKASPAKEKLSNFPLRPPVVTIMGHVDHGKTRLLDAIRSTNVMEKEVGGITQHIGAYQVEIKGHKITFLDTPGHEAFTAMRARGAQATDITILVVAADDGVMPQTLEALDHAKAAGVPIILAINKMDKPEANPDRVKQQLAEVGLVVEEWGGDTLAIPTSARENKGINELLEAVLLIAELEDLRADPNQPASGVVIEAEMDKTKGPMATVLVQSGTLKLGDTVVAGNTWGRVKAMFNDVGKRIKKAEPSTPVALLGMESVPQVGDKIIAVATEKQARDMVNENSQSTRKTNAVSLTNVYDQVSQGNIKELNIILKTDVQGSLEPIKDSLEKLSTDKIKININRSGAGNVTESDVMLAMASGGLIIGFSTGIETNAQRLADAEDIDIRHYDIIYKLIEDVDKALQGLLEPTIKEVIDGRAEVRAVFESTKKLSIAGCMVLEGKLVKNSQVRLLRGGEVIVDAPSNSLRRFKEDVKEVVAGYECGVGLKDFNEFQKSDILEFYHKEKSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_PROA2
Sequence: MAEKITLRETDYSQWYIDLVRSAKLADYSDVRGCMIIRPNGYAIWEKMQAALDAMFKATGHVNAYFPLFIPESFIKKEAEHIEGFAPECAVVTHGGGEQLAENLYVRPTSETIIWSSYKKWIQSYRDLPILINQWANVVRWEMRTRLFLRTTEFLWQEGHTAHATSTEAQEEVMRMINVYKTFAEEYMALPVIMGRKTESEKFAGAVETWCIEAMMQDKKALQAGTSHNLGQNFAKAFDCRFQSKEGALEYVWATSWGVSTRLIGALIMAHSDDRGLVLPPKLATRQVVIIPILKGDISAVIEKARSIAAELNQKGIAAFVDDSDQNSPGWKFAEYELQGIPVRLELGPRDIQSSTCIAARRDTGEKSKLQLDSSLADQINSLLESIQTNLFNRALSFREKHTLEVSSYSEFKANIDNGFLVAHWDGTDETEAKIKEETKATIRVMPADPEMVLRYGMDQPGTCIYSGKPSTRKVIFAKAY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.