PharMolix/UniProtQA huggingface dataset:
Protein: M3K14_MOUSE
Sequence: MAVMEVACPGTPGSAVGQQKELAKAKEKTQSLGKKQSCIFKLEAVEKSPVFCGKWEILNDVITKGTAKDGSEGGPPAISIIAQAECENSQEFSPTFSERIFIAGSQQYSQSESLDQIPNNVAHATEGKMARVCRRGKRHGKARKKRRKKRSKSLAQAGVALAKPLPRTPEQESCTIPVQEDESPLGNLYARNVSQFTKPLGGPGLGHLCFKKQDEGLRPVLPRPELHKLISPLQCLNHVWKLHHPQATGPRPHPTHPFPYSGMPHPFPFYPLEPWKPYMLDSAVLDKLAGVSGQRPLPGPPHLSQLAHGDSQKPLPGPHLESSCPSRGALEKVPVEEYLVHALQGSVSSGQAHSLASLAKTWSSGSAKLQRLGPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLKSPWKGEYKEPRPPPQDQATCHQTLPTPPRENPPAKANTDGAPEPQPPLPPEPPEPSKAPALNLSKEESGTWEPLPLSSLDPATAKGPSFPDRRATLPELELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWNSQAEARTCSCSTALARGRPTDIPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPATAFSLVTKDGQPVCYDMEVPDSGIDLQCTLAPDGSFAWTWRVKHGQLENRP
What is the function of this protein?
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.  Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway.  Could act in a receptor-selective manner.
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, Serine/threonine-protein kinase NIK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AVT5_SCHPO
Sequence: MSGYSPLSSGPADVHIGKAGFFSSVINLANTILGAGILSLPNAFTKTGLLFGCLTIVFSAFASFLGLYFVSQCAARLPRGKASFAAVAKHTFPSLAVVFDASIAVKCFGVAVSYLVIVGDLMPQIAPSLGLSSPMFLRRQTWIVFALFVLTPLSFLKRLDSLRHTSVISLIALCYLVFIVLYHFIIGDTVKGEIRYFVPESGFGYLSVLPVFVFGFTCHQNAFSVINEVRNFSQGFVNFTMFTAIISSTLLYLLVAITGYLSFGSLASGNIIAMYDNTSIWIIGGKLAIVVLVLFSYPLQCHPCRNSVYQAIRRSYSAHDMSDGYHAVITLCILLFTHSLALLLSSLEMVLAFVGSTGSTFISFILPGSLYYFFSHKVASPGNSSPLQLRISRAFAAGLAIYGTVVMILCLNINIAKLSH
What is the function of this protein?
Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine.  Required for sporulation.
What are the official names of this protein?
Vacuolar amino acid transporter 5.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: ASNS2_LOTJA
Sequence: MCGILAVLGCSDDSQAKRVRVLELSRRLKHRGPDWSGLHQHGDNFLAHQRLAIVDPASGDQPLFNEDQSIIVTVNGEIFNHEELRKQLPNHKFRTGCDCDVIAHLYEEHGENFVDMLDGIFSFVLLDTRDNSFLVARDAIGVTSLYIGYGLDGSVWIASELKGLNDDCEHFELFPPGHLYSSKEKEFRRWYNPPWFSEAIPSAPYDPLALRQAFEKAIIKRLMTDVPFGVLLSGGLDSSLVASVTARYLADTKAAKQWGSKLHSFCVGLEGAPDLKAAREVADYIGTVHHEFQYTIQDGIDAIEDVIYHVETYDVTTIRAGTPMFLMSRKIKSLGVKMVLSGEGSDEIFAGYLYFHKAPNKEELHQETCSKIKALHKYDCLRANKSTYAWGLEARVPFLDKKFIDVAMGIDPENKMIKRDEGRIEKWVLRKAFDDEENPYLPKHILYRQKEQFSDGVGYGWIDGLKDHAAKHVTDKMMLNASNIYPFNTPNTKEAYYYRMIFERFFPQNSARLSVPGGASIACSTEKAIEWDAAWSNNLDPSGRAALGVHDSAYDDQLNKSVSKGVEPEKIIPKMEVSPLGVAILS
What are the official names of this protein?
Asparagine synthetase [glutamine-hydrolyzing] 2, Glutamine-dependent asparagine synthetase 2.
Protein: COBQ_BURPS
Sequence: MIQGTTSDAGKSTLVAGLCRLARRTGARVAPFKPQNMALNSAVTANGGEIGRAQALQALAAGIEAHTDLNPVLLKPTGDRGAQVIIHGKARANLDARAYHDYKPTAMRAVLESYGRLRGAYDAVIVEGAGSPAEINLREGDIANMGFAEAVDCPVVLVADIDRGGVFAHLVGTLACLSDSERARVRGFVINRFRGDPALLEPGLRWLEARTGKPVLGVLPYLHGLTLDAEDMLPASARTSAARRDAGVLRIVVPALPRISNHTDFDALRAHPRVDFTYWRRGPVPDADLLILPGSKNVLADLAWLRDAGWDALIKRHLRYGGKVIGICGGMQMLGRTLADPHGVEGAAGATSAGLGLLDYATTLTPEKTLVNAAGRLAFGGDARVAGYEIHMGRTEGPALASPALMLAGRGGERPDGALSADGQILATYLHGLFDTPHACAALLEWAGLDGAEALDYPALREASLERLADTFAEHLDLDRVFAAFA
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: THIM2_STRP7
Sequence: MQEFTNPFPIGSSSLIHCMTNEISCEMLANGILALGCKPVMADDPREVLDFTKQSQALFINLGHLSAEKEKAIRMAASYANQSSLPMVVDAVGVTTSSIRKSLVKDLLDYRPTVIKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYPGMSFLVTGPKDLVVSKNQVAVLENGCTELDWITGTGDLVGALTAVFLSQGKTGFEASCLAVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSLLRRDENWLDTIKGEVYE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 2, 4-methyl-5-beta-hydroxyethylthiazole kinase 2, TH kinase 2, Thz kinase 2.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: OBG_SALPK
Sequence: MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRDLLLELMLLADVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDSEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGSDPVENARIIIGELEKYSQDLAAKPRWLVFNKIDLMDKTEAEEKAKAIAEALGWEGKYYLISAASQLGVKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQLAEVEEDADDDWDDDWDEDDEEGVEFIYKR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_STRPQ
Sequence: MSKQTLVLLYGGRSAEREVSVLSAESVMRAVNYDKFLVKTYFITQMGQFIKTQQFSEKPSESERLMTNETIELTQKIKPSDIYEEGAVVFPVLHGPMGEDGSIQGFLEVLRMPYIGTNVMSSSIAMDKITTKRVLESIGIPQVAYTVYIDGQDLEACLVETLARLTFPIFVKPANMGSSVGISKAQTKVELRKAIQLALTYDSRVLIEQGVVAREIEVGLLGNDKVKSTLPGEVIKDVDFYDYQAKYVDNKITMAIPADVDQSIVTEMRSYAEVAFKALGGCGLSRCDFFLTQDGQVYLNELNTMPGFTQWSMYPLLWENMGLAYPDLIEELVTLAQEIFDQRESHLI
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPS_SALDC
Sequence: MSTAKLVKTKASNLLYTRNDVSESDKKATVELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALTDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYPLDIHNVQDHLKELADRYAVVANDVRKAIGEAKDEDTADIFTAASRDLDKFLWFIESNIE
What is the function of this protein?
During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages.  It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction.  One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
What are the official names of this protein?
DNA protection during starvation protein.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXEC2_ORYSJ
Sequence: MSAATACASPAAARPPLHIPLRSPPSAAHLPSAAASRRASSAACRCTASASASASPSTWDWTRWTRHFADVDQAESYASLLKFQLEEAVDNEDFAEASKLKKAILEATGNDAVAQVMSELKTAIEEQRYQDASRLTKLARTNLVGWWVGYAKDTDDSIGRIVRISPGVGRYVAKSFSPRQLVTASSGTPLFEIFLVRDDDETYTMKVVHMRPTKGTSSASSVSSATAESPAKEENESSLESSAISEGITDEANTDTTLKGDEDVEDKEQDVGNAKDSSVEGLKSVLNFFKSRIPEFKVQVINVDVSEEAELASDSSEELVQDDVKSTSENSLEDSTTEELQQDDVPDGDSDSAEDSKSPEMKLFISGVVHNKEDAGAKSYVRVPAEINNLEKDSFELYIPGKGSDRDLADTKAAKQKVADMAAKLASELMPSDVAKALWGTTKSSSKINKEVQELLKLTLSKARVKLTENTIFNRIITDSNGSDPFSGLYVGAFSPYGPEVVQLRRKFGHWNSTDEVEFFEYVEAVKLTGDLSVPAGQITFRAKIGKGKRLENRGAYPEEFGVIASYKGQGRIAQPGFKNPRWVDGELLVLNGKSTIPHLGGAELGFLYSVPEQSFLVLFDRLKLPE
What is the function of this protein?
Together with EX1, enables higher plants to perceive singlet oxygen as a stress signal in plastid that activates a genetically determined nuclear stress response program which triggers a programmed cell death (PCD).  This transfer of singlet oxygen-induced stress-related signals from the plastid to the nucleus that triggers genetically controlled PCD pathway is unique to photosynthetic eukaryotes and operates under mild stress conditions, impeding photosystem II (PSII) without causing photooxidative damage of the plant.
What are the official names of this protein?
Protein EXECUTER 2, chloroplastic, OsEX2.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DMPO_PSEUF
Sequence: MTVNSIGEYTATPRDVQANFNGMQLLYLYWEEHLMYCSALAFLVAPGMPFAEFLEQVLKPAIHAHPDSAKIDFSQALWQLNDQPFTPDYAASLEANGIDHKSMLRLNTPGLNGIQGSCS
What is the function of this protein?
Part of a multicomponent enzyme which catalyzes the degradation of phenol and some of its methylated derivatives (PubMed:2254259).  DmpL, DmpN and DmpO form the oxygenase component of the complex (PubMed:12186554).  Required for growth on phenol and for in vitro phenol hydroxylase activity (PubMed:2254258, PubMed:2254259).
What are the official names of this protein?
Phenol 2-monooxygenase, oxygenase component DmpO, Phenol 2-monooxygenase P4 component, Phenol hydroxylase P4 protein.
Protein: PURL_CAMC1
Sequence: MDKATIQAHKISDEEYEEILKILGREPNLLELGIFSAMWSEHCSYKSSKKYLNGFPTKAPWVIQGPGENAGVIDVGDGVAAVFKMESHNHPSFIEPFQGAATGVGGILRDVFTMGARVVANMNSLRFGEIRGESELAKKHRYLLKGSVAGIGHYGNCMGIPTIGGETTFDPSFNGNILINAFALGLCKSDEIFYGKAEGVGNPVIYVGSKTGRDGLGGAVMASDSFNDENKSLRPTVQVGDPFAEKLLMEACLELFKKDYIIGIQDMGAAGLTSSSFEMAGRSGSGMKMYLDRVPMREVGMTPYELMLSESQERMLICAKKGFEQKVLEIFRKWDLDAEIIGEVTSSGVMQLYWHDELAGEIPIGPLSEAAPVLDRPVARPKYLDEIANLEIPNNIDNKTAFFKLLKEPEVLNKSFIYDQYDANIQTNTIKQPGCLGAATIRIKESGRAIAMAAQCDPRANFVDPKIGAARAVAAAGRKVAMSGAVPLAITDCLNYGNPQNPEVMWQFKEGCEGIKEACRELNTPVVSGNVSLYNDTDGISVYPTPAIVTVGVNEDANLNLKSTFSSEGRAIYLLGETSGEFAASLYAKALFNVVGGKLKEVDYKAERALWELVIEANKEQILEFANSVGVGGLAITLAKMASISNIGVNCEVKFKEPNFIFDESFSRAVVGVKDEAKFEALATKFGVKFEKIGVSGGKRFKLNEIDESLEDVREIYLNEFAKIVKKED
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUXS_ACTPJ
Sequence: MPLLDSFKVDHTRMNAPAVRVAKTMTTPKGDTITVFDLRFCRPNIDILPVRGIHTMEHLFAGFMRDHLNSESVEIIDISPMGCRTGFYMSLIGAPSEADVVSAWTKSMEDALNKVPDVSKIPELNEYQCGSYKEHSLEEAHQIARDVLAKGIGVNRNEDLALDEKLLNP
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: YJU2B_RAT
Sequence: MGERKGQNKYYPPDFNPEKHGSLNRYHNSHPLRERARKLSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPANCDYVIVSGASRKEERWDMEDNEQVLTTEHEKKEKLETDAMFRLEHGEADRSTLKKALPTLSHIQEAQNAWKDDFALNSMLRRHFREKKKAMQEEEEKDQALQAKANLAIPLVPESEDDRRLAALLRLHTLDSYEDKQRMKRTEIIHRSWFPSAQGPSTSSSKASTVLKKLCRGRRPPTGSAGAPGDLGIVRRKSREAPESPQCTADNSLSEEPRGPPGTTPDSKTLQGTAEAPRTSKTLESKRNCSDQALPLGSSQEDLLHPNTPNASLVADYSDSESE
What is the function of this protein?
May be involved in mRNA splicing.
What are the official names of this protein?
Probable splicing factor YJU2B, Coiled-coil domain-containing protein 130.
What is the protein family that this protein belongs to?
Belongs to the CWC16 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MATK_BATMA
Sequence: MEEFQVYLELHKAHNFLYPLFFQEYIYALAHNHRLNRLNRSSLFQNGDYDNKFSSLIVKRLIFRMYQQNNFIISTKNLNQNTFFSHNKNLYYQIISVVLAVIVEIPFSIRFISSLEGKELVKSHNLQSIHSIFPFLEDKFSHLNYVLNVLIPHPIHLEILLQTLRYWIKDASSLHLLRFYLYEYSNLKNFFIPKKSTLNPRFFLFLYNSYVYQYESILFFLRKQSSHLQSNSFGILIERIYFYGKIESLLKVFIKKFQDILWLSKDPFMHYVRYRGKSILASKHGPLLISKWKYYFVNLWQCHFYVWSQSKRVHIKQLSKDYLNFLGYLSSLRLNFLVVRSQMLENSYLIDNVIKKFHTKIPMSSIIASLAKARFCNVLGHPISKSTWTDSSDSEILDRFVRIYRNLAHYYSGSSKKKNLYRIKYILRVSCVKTLARKHKSTVRAFLKRLGSDFLEEFLLEEEQVLSLMFSRVFSVSQRFYRVRIWYLDIFYINDFVNH
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PCKA_BACC3
Sequence: MSTVNVQIGLHELLNGSNAQIQLSVPQLVEKVLMRNEGKLTSTGAVSASTGKYTGRSPKDKFIVKEASVADKIAWGAVNQPISEEHFNKLYTKVLEYLKEKEELFVFKGFAGADRNYRLPIQVINEYAWHNLFVHQLFIRPTEEELTTHESEFTIVSAPNFKADPAVDGTNSEAFIMVSFEKRIVLIGGTEYAGEMKKSIFSIMNFLLPEQDILSMHCSANVGEEGDVALFFGLSGTGKTTLSADPNRKLIGDDEHGWSDNGVFNIEGGCYAKCVNLSHEKEPQIFDAITFGSVLENVIINDQTRIADYNDTTLTENTRAAYPMHAIDNIVLPSVAGHPNTIIFLTADASGVLPPISKLSKEQAMYHFLSGYTSKLAGTERGVTSPQATFSTCFGSPFLPLDASRYAEMLGEKIEKHDAKVFLVNTGWTGGEYGVGKRMNLGYTRAMIQAALNGELAKTETAKHDIFGLEVPLHVPGVPDEVLMPEQTWADKAAYKAKAIELANEFKANFKKFDSVSEDIINLGGPIA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG055_MONPV
Sequence: MGFCIPLRSKMLKRVSRKSSSILARRPTPKKMNIVTDSENRLKKNSYIENTNQGNILMDSIFVSTMPVETLFGSYITDDNDDYELKDLLNVTYNIKPVIVPDIKLDSVLDRDGNFRPADCFLVKLKHSDGFTKGALYLGHSAGFTATICLKNEGVSGLYIPGTSVVRSNICQGDTIVSRSSRGVQFLPQIGGEAIFLIVSLCPTKKLVETGFVIPEISSNDNAKIAARILSEKRKDIIAHINTLIQYRQQLELAYYNSCMLTEFLHYCNSYADTIKESLLKETIQKDINIIHTNITTLLNETAKVIKLVKSLVDKEDTDIVNNFITKEIKNCGGVKNRDKIVNSLSLSNLDFRL
What is the function of this protein?
Stimulates increases in peripheral microtubule dynamics and may increase the motility of the infected cells, contributing to cell-to-cell spread of the virus.  Seems to inhibit the signaling via the GTPase RHOA and DIAPH1/mDia.
What are the official names of this protein?
Protein OPG055, Protein F11.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG055 family.
Protein: AGN4_PAEDI
Sequence: MATYAVLGATGNCGTALIDNLLRTEGAQIHAFCRNKPKLMQKMPALVDHKRVQIYEGSIDDIDLLAECIRGTRAIFHVVTTNDNVPGCQVGLDTAQSIIAALESLQALEPEGTKPPKIVLLSSGTIDDHLSRHMPSFFRRILRAAASHVYEDLRRTEAFLRAQPDGVSTIFIKPGGLSIDVQRGHALNLDRDESFVSYLDLAAAMIEAADDPDDRFDGKNVSVANTNGAARFPMGTPLCILTGLARHSFPWLHRYLPATGPG
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of agnestins, dihydroxy-xanthone metabolites (PubMed:30746079).  The pathway begins with the assembly and cyclization of atrochrysone thioester by the non-reducing polyketide synthase Agnpks1 (PubMed:30746079).  The atrochrysone carboxyl ACP thioesterase AgnL7 then breaks the thioester bond and releases the atrochrysone carboxylic acid as the first enzyme-free intermediate (PubMed:30746079).  The decarboxylase AgnL1 then catalyzes the concerted decarboxylation-elimination required to convert atochrysone carboxylic acid into emodin anthrone, which is further oxidized to emodin by the anthrone oxygenase AgnL2 (PubMed:30746079).  Emodin then undergoes reduction catalyzed by the oxidoreductase AgnL4 to yield the dihydroquinone tautomer which is the substrate for reduction by the short chain dehydrogenase AgnL6 reduction to produce hydroxyketone, followed by AgnL8 dehydration and likely spontaneous autoxidation to chrysophanol (PubMed:30746079).  Baeyer-Villiger oxidation by the oxidase AgnL3 leads to monodictyphenone via cleavage of the C-10/C-10a bond of chrysophanol (PubMed:30746079).  Alternative cleavage at the C-4a/C-10 bond of chrysophanol leads also to the formation some cephalone F (PubMed:30746079).  Further conversion to agnestins A and B, requires reduction to dihydro-monodictyphenone, oxidation to agnestin C probably via an epoxide, and rearrangement to either agnestin A or agnestin B directly, although agnestin A or agnestin B can also interconvert (PubMed:30746079).  Within the cluster, AgnR1 is the only unassigned oxidoreductase present which could be involved in this conversion.  However, AgnR1 seems not to be involved in this step, and thus genes involved in the proposed oxidation/reduction may be located elsewhere on the genome (PubMed:30746079).  Further agnestin A derivatives are probably formed by spontaneous decarboxylations, dehydrations and methanolysis reactions (PubMed:30746079).
What are the official names of this protein?
Oxidoreductase AgnL4, Agnestins biosynthesis cluster protein L4.
What is the protein family that this protein belongs to?
Belongs to the avfA family.
Protein: AGRB_STAIN
Sequence: MLLIDNGIEKMALKLQQRQNLSHIEFLKVRLGMQVVVINTFKAIVTYGLALLLNIFLYTLIVHLTFLTLRTYSHGAHAKTSMLCHVQNIVAFVMLPWLIVQYDISFQFLLILSLLSALIVIKYAPAATKKRPIAPKKVKGLKIKSIIVFVLLMTIACIVPPPYNRFVVYGVLLQSFTLLPIFSIKEEV
What is the function of this protein?
Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP).  This quorum sensing system is responsible for the regulation of the expression of virulence factor genes.  Involved in the proteolytic processing of AgrD, the precursor of AIP.
What are the official names of this protein?
Accessory gene regulator protein B.
What is the protein family that this protein belongs to?
Belongs to the AgrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: STAT2_HUMAN
Sequence: MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLFFHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQPFSQDPTQLAEMIFNLLLEEKRILIQAQRAQLEQGEPVLETPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRYKIQAKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIELLLPKLEEWKAQQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLTKGVDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTVEVSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKGSNKGPLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLSPNLQNQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLLSWADFTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTMSGTFLLRFSESSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENPLRFLYPRIPRDEAFGCYYQEKVNLQERRKYLKHRLIVVSNRQVDELQQPLELKPEPELESLELELGLVPEPELSLDLEPLLKAGLDLGPELESVLESTLEPVIEPTLCMVSQTVPEPDQGPVSQPVPEPDLPCDLRHLNTEPMEIFRNCVKIEEIMPNGDPLLAGQNTVDEVYVSRPSHFYTDGPLMPSDF
What is the function of this protein?
Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta).  Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2.  The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus.  ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734).  In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510).  Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121, PubMed:23391734, PubMed:9020188).
What are the official names of this protein?
Signal transducer and activator of transcription 2, p113.
What is the protein family that this protein belongs to?
Belongs to the transcription factor STAT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Protein: TDCB_STAAB
Sequence: MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQSITKGNVFLKLENMQFTGSFKFRGASNKINHLTDEQKEKGIIAASAGNHAQGVALTAKLLGIDATIVMPETAPQAKQQATKGYGTKVILKGKNFNETRLYMEELAKENGMTIVHPYDDKFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQSENVHGMAESFYKRDLTEHRVDSTIADGCDVKVPGEQTYEVVKHLVDEFILVIEEEIEHAMKDLMQRAKIITEGAGALPTAAILSGKINNKWLEDKNVVALVSGGNVDLTRVSGVIEHGLNIADTSKGVVG
What is the function of this protein?
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction.  The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate).  Both intermediates are unstable and short-lived.  The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia.  In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
What are the official names of this protein?
L-threonine dehydratase catabolic TdcB, Threonine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: NRDI_ECO57
Sequence: MSQLVYFSSSSENTQRFIERLGLPAVRIPLNERERIQVDEPYILIVPSYGGGGTAGAVPRQVIRFLNDEHNRALLRGVIASGNRNFGEAYGRAGDVIARKCGVPWLYRFELMGTQSDIENVRKGVTEFWQRQPQNA
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: Y9540_HAEIG
Sequence: MEIVNKQSFQDVLEYVRMYRLKNRIKRDMEDNNRKIRDNQKRILLLDNLNQYIRDDMTIAEVRGIIESMRDDYESRVDDYTIRNAELSKQRREASTKMKEQKKAHAELLKNAEK
What are the official names of this protein?
UPF0265 protein CGSHiGG_09540.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.