PharMolix/UniProtQA huggingface dataset:
Protein: CH601_SACEN
Sequence: MAKMIAFDEDARRGLERGMNTLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPWEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGASPIALKRGIEKATEAIAEQLLKSAKEIETKDQIAATAAISAGDRQIGELIAEAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFVTDSERMEASLDDPYILLLSSKISNVKDLLPLLEKVMQANKPLLIISEDVEGEALATLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLKLESADLSLLGRARKVVVTKDETTIVEGAGDDEQIAGRVNEIRAEIERSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGVLAGGGVALLQATVAAFDGLKLEGDEATGANSVRLAVEAPLKQIAVNAGLEGGVVAEKVKNLTPGHGLNAATGEYEDLLAAGIIDPAKVTRSALQNAASIAALFLTTEAVVADKPEKEAAGAAAGADPMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_LEPIC
Sequence: MKKERLEQASAFGKDRVKKKKNTDTSSNLIPVPKGATKEKKRVGRGPGSKVGKTAGRGSKGQYARNTVRRGFEGGQMPIHRRLPKRGFTSKFHKEFYPVNLRDIEKSGLTGNIDAKIMVQSKILDKETTLFKILGTGEIKKAIHVIADGFSQSAKEKIEKAGGSIKLRAELKLATSETKK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: SSPH1_CLOBL
Sequence: MDASRASQLINSKASYVYCKGKPVIIKSVDESSKMATVQSVDNGATMIAPLNDIRESGVINNQNS
What are the official names of this protein?
Small, acid-soluble spore protein H 1, SASP H 1.
What is the protein family that this protein belongs to?
Belongs to the SspH family.
What are the subcellular locations of this protein?
Spore core.
Protein: RECX_LACDA
Sequence: MAIITKVSAQKRQGRYNIFLDQEYAFSVSEKTLAEFVLLKGQELSPQKINEILDYEASAKASDLAARYLSYQPRTIKEVTDYLSQHEISRSAAKRAVNELTHLGYLDDAAYARLFVKNNLQVGKNGPGAVRRDLKKKGVDDDLIEAALADVTDEEWAGVGKRLVKSLLGQQGKIAKREVDRKMQTKLLSHGFSGSLAQAVTQDLVPEADEDQERAALVKQVLKAYKRFKRYEPGVREQKMRQYLYSHGFSGDEISAFLVGEIIPLEELEEY
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_PHOLL
Sequence: MSSKLVLVLNCGSSSLKFAIIDPANGEEYLSGLAECFNLPEARIKWKMDGAKHEAALGAGAAHSEALNFIVNTILAEKPELSDQIAAIGHRIVHGGEKFTASVTINDEVIQGIKDAVPFAPLHNPAHLIGIEEAKKGFPHLADKNVAVFDTAFHQTMPEEAYLYALPYNLYKEHGIRRYGAHGTSHFFVSREAAKTLNKPVEELNVIVCHLGNGGSISAIVNGQCVDTSMGLTPLEGLVMGTRSGDIDPAIIFHLHDSLGMSVEQINKLLTKESGLLGLTEVTSDCRYIEDNYATKADAKRAMDVYCHRLAKYVGAYSALMEGRLDAIIFTGGIGENSALVREQVMKKLALLGFEYDHDRNLAARFGKSGAITTDNSRPALVIPTNEELVIAQDAARLTA
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB12_MOUSE
Sequence: MDPSAALHRRPAGGSLGAVSPALSGGQARRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREISRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDVLRNELSNSILSLQPEPEIPPELPPPRPHVRCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity).  That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.  Involved in autophagy.
What are the official names of this protein?
Ras-related protein Rab-12, Rab-13.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome.
Protein: GATC_RUEST
Sequence: MSIDQSTAAKVAKLARIKVEEDALPALAEEFNTILGFIEQLNEVDVEGVEPMTSVTPQRLKRREDVVTDGNQQDKVLANAPDAREGFFAVPKVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: GUAAB_HALSA
Sequence: MVDVDSFVEDARAEISEALGDETAIIALSGGVDSSTAAALAYEAVGDQLVPVYVDTGLMRKGETDEIREVFDYMDSLRVVDASDRFFDELAGVTDPEEKRHAIGEQFIREFETVAEEVDATQLVQGTIYPDRIESEGTIKSHHNVGGLPERVGFEGIVEPMRDLYKDEVREVARHLGLEEIISERMPFPGPGLAVRVIGEVTPEKVAVCREATHIVEDELEAYEPWQAFAAVLGRATGVKGDNRVHGHVVAVRSVESRDGMTARAQELEWETLQRLQSRIAGTIDEVSRVVYDVTHKPPATIEYE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase.
Protein: FLRT3_MOUSE
Sequence: MISPAWSLFLIGTKIGLFFQVAPLSVVAKSCPSVCRCDAGFIYCNDRSLTSIPVGIPEDATTLYLQNNQINNVGIPSDLKNLLKVQRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPGGLPRTIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLSAELFDCKDSGIVSTIQITTAIPNTAYPAQGQWPAPVTKQPDIKNPKLIKDQRTTGSPSRKTILITVKSVTPDTIHISWRLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPESPYRVCMVPMETSNLYLFDETPVCIETQTAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALVSIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPISNEPISKEEFVIHTIFPPNGMNLYKNNLSESSSNRSYRDSGIPDSDHSHS
What is the function of this protein?
Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners (PubMed:19056886, PubMed:25374360).  Plays a role in the spatial organization of brain neurons (PubMed:25374360).  Plays a role in vascular development in the retina (PubMed:25374360).  Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:25374360).  Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577).  Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (PubMed:21673655, PubMed:25374360).  Promotes neurite outgrowth (in vitro) (By similarity).  Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length (By similarity).  Plays a role in the regulation of the density of glutamaergic synapses (PubMed:22405201).  Plays a role in fibroblast growth factor-mediated signaling cascades (PubMed:16872596).  Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning (PubMed:19056886).  Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development (PubMed:18448090).  Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (PubMed:19056886).
What are the official names of this protein?
Leucine-rich repeat transmembrane protein FLRT3, Fibronectin leucine rich transmembrane protein 3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cell junction, focal adhesion. Secreted. Cell projection, axon. Cell projection, growth cone membrane. Note=Detected on dendritic punctae that colocalize in part with glutamaergic synapses, but not with GABAergic synapses. Proteolytic cleavage in the juxtamembrane region gives rise to a shedded ectodomain (PubMed:21673655).
Protein: TSAD_FRATF
Sequence: MIVLGIESSCDETGLAIYDYSKKKLIADELYSQVKLHKKYGGVVPELASREHIAKLNLLAKKIFKETGLSFEDIDCIAYTAMPGLVGALMVGATFAKTLGLIHNIDTIAVHHLEGHLLSPLLDHNSNIEYPFVALLVSGGHTQLFEVKEFGEYSLLGESIDDAAGEAFDKTTKLLGMGYPGGVEVANLADQATDKSKYILPRPMKNKPNLDFSFSGLKTAVLNTWYDEQDQSLENKANLCYALQNAAIDVLVSKCAKALQKTKNTRLVISGGVSANKLLRHQLDLLAKNREYQIFFPPMKYCTDNGAMIALAGAYRYVNGFKDSNLEINVKARSPL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTE_SALTY
Sequence: MDNFLALTLSGTTPRVTQGKGAGFRWRWLGHGLLELTPDAPVDRALILSAGIHGNETAPVEMLDKLLSALYSGSLTLTWRVLVVLGNPQALAAGIRYCHSDMNRMFGGRWQSFAESDETRRARELELSLETFFSSGQARVRWHLDLHTAIRGSHHLRFGVLPQRDRPWETDFLAWLGAAGLEALVFHQAPGGTFTHFSSEHFGALSCTLELGKALPFRQNDLTQFNVTSQALSALLSGVETSTSFSPPLRYRVVSQITRHSDKFALYMDAQTLNFTAFAKGTLLAEEGDKRVTVTHDVEYVLFPNPSVACGLRAGLMLERLP
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: FCER2_HUMAN
Sequence: MEEGQYSEIEELPRRRCCRRGTQIVLLGLVTAALWAGLLTLLLLWHWDTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADLSSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVCNTCPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS
What is the function of this protein?
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21.  Has essential roles in the regulation of IgE production and in the differentiation of B cells.  On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225).  On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003).
What are the official names of this protein?
Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.
Protein: ALB1_VANPO
Sequence: MPSKNSINRPKLTVNLNKKSQRLGQKRADRERKGLLQPERSSEASKSGEIKSVPLDLYFNGKESNNNSSITTKTLSKKRAKKIERNLKYAQQRKLLVDVQAKEDIDMNVESNKTKGNGKEKTPLTKMKDALWNVIEDTSSQGLTLKTGQGTTLGGPTF
What is the function of this protein?
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.  Accompanies the pre-60S particles to the cytoplasm (By similarity).
What are the official names of this protein?
Ribosome biogenesis protein ALB1.
What is the protein family that this protein belongs to?
Belongs to the ALB1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ENO_BEII9
Sequence: MTAIVDIAAREILDSRGNPTIEVDVTLEDGSQGRAAVPSGASTGAHEAVELRDGDKSRFGGKGVLKAVENVDRDIFDALSGLDAEDQVHIDQVMLELDGTPNKGRLGANAILGVSLAVAKAAAEASSLPLYRYVGGVQARVLPVPMMNIINGGAHADNPIDFQEFMILPVGAPNLKEAVRWGAEVFHVLKGALKKAGHNTNVGDEGGFAPNLPSAEASLEFIVKAITDAGFKPGEDIYLGLDCASTEFFKDGKYVYEGEGKTRNLEEQAAYLGKLVESFPIVTIEDGMSEDDWEGWKILTDLIGKKCQLVGDDLFVTNVSRLSQGISKGIANSILVKVNQIGSLTETLAAVDMAQRAGYTAVMSHRSGETEDSTIADLAVATNCGQIKTGSLARSDRLAKYNQLIRIEEELGSQAVYAGRAALKALA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: TUSD_ECO45
Sequence: MRFAIVVTGPAYGTQQASSAFQFAQALIAEGHELSSVFFYREGVYNANQLTSPASDEFDLVRSWQQLNMQHGVALNICVAAALRRGVVDETEAGRLGLASSNLQTGFTLSGLGALAEASLTCDRVVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_FRATW
Sequence: MTNISVIAKPYAKAAFEFANEHNLLQQWSKLLQTFSELIKDKSVAAIVSSPTISQIEVVDALKKQLDENFFNFLALIAENKKMLIMPEIADQFESIKNIHNNVRVADVTLAYATDKNILDSLKTSLEKKFGCTIDMHINIDPAIIGGAVVKVGDTVIDSSVSGHLEKLKSILLS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GSPJ_KLEPN
Sequence: MIRRSSGFTLVEMLLALAILAALSVAAVTVLQNVMRADTLTRDKSGRMQALQQTFSQMAADFSQIIPRRSRDSASLFFAGRFQLGSDDGAIAFSRNGWPNPLGLLPRSEIQNVSYRLRGSQLERLNYDQQDPLPGSQPTVTIVLRDVRAFGLRFYASGRWQDEWQQAQTLPQGLEVTLTLEPYGEIRRLFLLTPGDSR
What is the function of this protein?
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.
What are the official names of this protein?
Type II secretion system protein J, T2SS protein J, General secretion pathway protein J, Pullulanase secretion protein PulJ.
What is the protein family that this protein belongs to?
Belongs to the GSP J family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: HEM3_RHOBA
Sequence: MAPTPPSDTTRLRIATRESPLAMWQAEHVAKLLKKHGFQTEIVPLVSKGDTDMRPIDGTRQVGLFTKRIQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTGAESPLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAHAGILRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAERKVLSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQEDARITVQPNDADLHVAEAHELGTLVAKRLRDKGADKLISTVRENH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: O366_CONTS
Sequence: MSGLGIMVLTLLLFMFMATSHQDAGEKQATQRDAINVRRRRSITRRGDEECNEYCDDRNKECCGRTNGHPRCANVCFG
What are the official names of this protein?
Conotoxin TsMSGL-12.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O3 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EX7L_NITEC
Sequence: MTDNNLFPEPKKIVWRVSELNRHVRVILEQTFPLLWVSGEISNLKRYPSGHWYFSLKDDNAQVRCVMFRHKNMYLDWMPQDGAQVEAQALITLYEARGEFQLTIERLRRAGLGVLFETFERLKTRLQQEGLFNPEYKQLIPPYPQQIGIITSTNTAALRDVLTTLQRRLPSLPVVIYPAPVQGKEAASAIVTALQIATQRSECDVLILCRGGGSIEDLWAFNEEIVARAIAACPIPIVTGIGHETDFTIADFVADMRAPTPTGAAQLAAPDRQDILHRLQYWQHRLQQAIERNIERRMQTTDLLAHRLVHPGERIRYQLIHLSQLHNRLLHAWSRQLEVCKWRIEAFRRRIQFTKPDINTGKRYQQELAARLQRAMVYRLESLQVQLIRQQQHLAHLDPKAVLERGYSITYTAGGEILQDSQQIHTGDNVQIVFAKGSAKANITETNK
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REP_CLOPF
Sequence: MRNALKLNKKNYIDNIHSRSKGWITRSVIDKKGYSQWHYKYAELKDLDMSDENIYITLNTFYKPCRRLENIKELNTLFIDLDYYKTGKTKDQVLMDLEKNYFNQSIPIPNYVIDSGRGMYLIWIINAVPSKALPLWKAVQEYLYNQLKYFGADRQALDATRILRVPGSINSKSKTVVNILDEYEYIYDLREIQNGFLPELKPYERKKGRPSKINYIYRERSLYYGRIQDIIKLCELREYDLKGHRELILFLYRYYLCSFTEDIEKALNDVLELNSMFRQHLSEREVIRATRSAERCYLDKNKQYKYKNETLIELLEITEEEQKYMTIIISKKEYKRRENIRGKKNYQEQLKAKGKATKKEELNVLRKKIKALKEKGFKNKEITLMLEVPIKTLERHITYMKKNGLL
What is the function of this protein?
Is involved in replication of pIP404.
What are the official names of this protein?
Replication protein, ORF5.
Protein: KLH25_HUMAN
Sequence: MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:27664236, PubMed:34491895).  The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813).  The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813).  The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:27664236, PubMed:34491895).  BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895).
What are the official names of this protein?
Kelch-like protein 25, Ectoderm-neural cortex protein 2, ENC-2.
Protein: QUEC_ALKCK
Sequence: MLEDKAVVVFSGGQDSTTCLFWAKERYRSLHAVIFDYGQRHKEEIQCAVDIANEQGVPYKVFDMGLLNQLTANALTRENISVQAGEAGESPSTFVAGRNHLFLSFAAVYAREMGAKHIITGVCETDFSGYPDCRDVFVKSLNVTLNLAMDEQFVIHTPLMWLNKKETWALADKMGQLEYIRAKTLTCYEGIRGDGCGTCPSCQLRQNGLDLYLREKAGAGQ
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: KEX1_ASPTN
Sequence: MVSLSLRGARRTAKDAASLPFLSWTLSLLALNPLLVSAKSAADYYVRSLPGAPEGPLLKMHAGHIEVDPENHGNLFFWHFQNRHIANRQRTVIWLNGGPGCSSMDGALMEVGPYRLKDNSTLEYNEGSWDEFGNLLFVDQPVGTGFSYVNGNQYLHEMDEMAAHFITFLENWFDIFPEYERDDIYIAGESFAGQHIPYIAKAIQERNEKAQMKPKWSLRGLLIGNGWISPKDQYPSYLTFAYEEGLITKDSRTAKNLEVLQSVCESRLEAGKNKIHLDDCEKVLSEMLTKTMDVSKNECINSYDIRLRDEAPACGMNWPPELTHMNYYLRQPELISALNINPEKKSGWMECSNAVSSTFRTQKSVPSVQLLPGLIESGIPILLFSGDKDLICNHVGTEELINNMKWNGGTGFETSPGVWAPRHDWTFEGEPAGIYQYARNLTYVLFYNASHMVPYDLPRQSRDMLDRFMQVDIASIGGSPADSRIDGEKLPQTSVGGHPNSTAAEEQEKKKMKEAEWKAYAKSGEAVLVVVIIGVIVWGFFIWRSRRHHRGYRSVYNKNMSGSSVLERFHSKRSGADMEAGDFDEAELDDLHSPGLDREHYAVGDDSDDEQQHQRQGSRPEGGQS
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase kex1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: PSBD_OLIPU
Sequence: MTIALGKFTKDEKDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFALIGFMLRQFELARSVQLRPYNAIAFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.