PharMolix/UniProtQA huggingface dataset:
Protein: RASF5_HUMAN
Sequence: MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGRSARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERGEGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG
What is the function of this protein?
Potential tumor suppressor.  Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation.  Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1.  Together with RAP1A may participate in regulation of microtubule growth.  The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing.  May be involved in regulation of Ras apoptotic function.  The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
What are the official names of this protein?
Ras association domain-containing protein 5, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
Protein: SD113_ARATH
Sequence: MGCLLILLLTLICFSLRLCLATDVITFSSEFRDSETVVSNHSTFRFGFFSPVNSTGRYAGIWFNNIPVQTVVWVANSNSPINDSSGMVSISKEGNLVVMDGRGQVHWSTNVLVPVAANTFYARLLNTGNLVLLGTTNTGDEILWESFEHPQNIYLPTMSLATDTKTGRSLKLRSWKSPFDPSPGRYSAGLIPLPFPELVVWKDDLLMWRSGPWNGQYFIGLPNMDYRINLFELTLSSDNRGSVSMSYAGNTLLYHFLLDSEGSVFQRDWNVAIQEWKTWLKVPSTKCDTYATCGQFASCRFNPGSTPPCMCIRGFKPQSYAEWNNGNWTQGCVRKAPLQCESRDNNDGSRKSDGFVRVQKMKVPHNPQRSGANEQDCPESCLKNCSCTAYSFDRGIGCLLWSGNLMDMQEFSGTGVVFYIRLADSEFKKRTNRSIVITVTLLVGAFLFAGTVVLALWKIAKHREKNRNTRLLNERMEALSSNDVGAILVNQYKLKELPLFEFQVLAVATNNFSITNKLGQGGFGAVYKGRLQEGLDIAVKRLSRTSGQGVEEFVNEVVVISKLQHRNLVRLLGFCIEGEERMLVYEFMPENCLDAYLFDPVKQRLLDWKTRFNIIDGICRGLMYLHRDSRLKIIHRDLKASNILLDENLNPKISDFGLARIFQGNEDEVSTVRVVGTYGYMAPEYAMGGLFSEKSDVFSLGVILLEIVSGRRNSSFYNDGQNPNLSAYAWKLWNTGEDIALVDPVIFEECFENEIRRCVHVGLLCVQDHANDRPSVATVIWMLSSENSNLPEPKQPAFIPRRGTSEVESSGQSDPRASINNVSLTKITGR
What is the function of this protein?
Receptor-like serine/threonine-protein kinase that represses the disease resistance signaling pathway triggered in response to bacterial pathogen such as Pseudomonas syringae pv.  tomato.
What are the official names of this protein?
G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13, Calmodulin-binding receptor-like protein kinase 1, Receptor-like protein kinase 2, S-domain-1 (SD1) receptor kinase 13, SD1-13.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RL19_COXBN
Sequence: MNNIIQLLETEQTQGKEIPDFRAGDTVTVQVKVKEGNRERLQAFEGVVIARRHRGLNSSFTVRKVSHGEGVERVFQLYSPLIASIKVNRRGDVRRAKLYYLRNLRGRKAKIKEKI
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: VP26A_HUMAN
Sequence: MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQASAEQPEM
What is the function of this protein?
Acts as component of the retromer cargo-selective complex (CSC).  The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.  The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway.  The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable).  The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable).  Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903).  Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922).  Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227).  Required for the endosomal localization of TBC1D5 (PubMed:20923837).  Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231).  Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403).  Involved in recycling of ADRB2 (PubMed:21602791).  Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 26A, Vesicle protein sorting 26A, hVPS26.
What is the protein family that this protein belongs to?
Belongs to the VPS26 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome. Note=Localizes to tubular profiles adjacent to endosomes (PubMed:15078903). Predominantly found in early not late endosomes (By similarity).
Protein: PYRE_STAAR
Sequence: MAKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKEHFPEVEVISGTATAGIPHAAFIAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIEDLISTGGSSVTAVEALKQAGAEVLGVVAIFTYGLKKADDTFSNIQLPFYTLSDYNELIEVAENEGKISSEDIQTLVEWRDNLA
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: PSBH_SYNS3
Sequence: MAQRTRLGDLLRPLNSEYGKVVPGWGTTPVMGIFMALFLVFLLIILQLYNKSLILEGINVNWNGLGLG
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: MURA_XANC8
Sequence: MAKIVVTGGQALHGEVHISGAKNAVLPILCATLLADAPVEISNVPHLHDVITTVKLLSELGAEVTIDEGTLAKGRSILVDPRSVTHQIAPYELVKTMRASILVLGPLLARYGTAEVSLPGGCAIGSRPVDQHIKGLQALGADISVENGYIKATSNGRLKGGRYVFDMVSVTGTENVLMAAVLAEGTTVLENAAMEPEVTDLADCLIALGAQIEGAGTPRITVQGVERLGGGHHAVLPDRIETGTFLVAAAMTGGSVTVRRARPDTLDAVLDKLTEAGATITTTADSVTLDMHGKRPRAVNLTTAPYPAFPTDMQAQFMALNCVADGVGVINETIFENRFMHVNELLRLGADIQVEGHTAIVRGAERLSGAPVMATDLRASASLILAGLVADGDTTIDRIYHLDRGYENIEEKLGALGATIRRIA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIHD1_MOUSE
Sequence: MADSTFLAPELSDTESMGEETVRFQELLLKASKELQQAQTARPDSTQIQPKPGFCVKTNSSEGKVFINICHSPSIPPPADVTEDELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSNFYLRMQNSDFLRELVVTIAREGLEDKYGLQLNPEWRMLKYRSFLGSISQQNIRSQQRPRIQELGTLDASGSLGTCHGPERPHLNLWLEAPDLLLAEVDLPKLDGAQGLALEIGENRLVIGGPQQLYHLDATVPLRINSEASRAAFHRRRKQLMVSMPLLTASS
What is the function of this protein?
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity).  Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity).  Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity).  Positively regulates the assembly and activity of the mTORC1 complex (By similarity).
What are the official names of this protein?
PIH1 domain-containing protein 1, Nucleolar protein 17 homolog.
What is the protein family that this protein belongs to?
Belongs to the PIH1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATL1_MOUSE
Sequence: MECCRRAAPGTPLLVLAFLLLSSRTARSEEDREGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKYHGQLYEWLPVSNDPDNPCSLKCQAKGTSLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSASKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGIFLVDNSTVDFQKLPDKEILRMTGPLTADFIIKIHDLGPADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENVKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPVVQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSAKTKPHIKEECIIPTPCYKPREKLPIEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIIRCQVLLPFSQSVADLPADECEGPKPASQRACYAGPCNGETPEFNPDNGDGLLGGLQDLDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRELADENLCVTSRRPPQLLKSCNLDPCPASHLLSREMNEVVVLADELCHHPKPSTVQACNRFNCPPAWYPAQWQLCSRTCGGGIQKRDVLCKQRMADGSFLELPETFCSASKPTSHQGCKKDDCPSEWLLSEWSECSVSCGEGTQTRSAICQRVLKTGVSTVVNSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARNIYIQTRRQRKLHFVVGGFAYLLPKTTVVLRCPTRRFRKPLITWEKDGQHSISSAHVTVAPFGYLKIHRLKPSDAGIYTCSAGPAREQFVIKLIGGNRKLVARPLSLWSEEEEALQVRKTNPKEALQTHKHQNGIFSNGSKAEKRGLTADPGNRYDDIVSRLLEQGGWPGELLASWEVQDSAERNASSEEDPNAEQALLHLPFTMVAEQKRLDDILRNLSQQPEELRDLYSKHLVAQLAQDIFRSHLENQDLLPKPSEQRFPPMAVPAHKHVSGFSSSLRSSSGEAGGGSRRPHRKPAILRKISAAQQLSASEVVTHLGQTVALASGTLSVLLHCEAVGNPRPTIHWTRNGEAVQFSDRILLQPDDSLQILAPVEADVGFYTCNATNALGYDSVSIAVTLAGKPLVKTSRMTVLNTEKPTVTVDIGGTVRTVRGVNVTINCQVAGVPEAEVTWFRNKSKLGSSHHLHEGSSHHLHEGSLLLTDVSFSDQGLYSCRAANLHGEQTESTQLLILDPPQVPTQLEDIRALLLATGPNLPSVLMSPLGTQLVLDPGNSALLGCPIKGHPTPNITWFQNGQPIATAPGLTHHIWGAGQILRVANLSGGPQGEFSCLAQNEAGTLLQKASLVIQDYWWSVDRLATCSASCGNRGIHQPRLRCLLNTTEVDPEHCTGKPRPAVQPVACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCSQLAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPRLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHVRTNKAVPEHLCSWGPRPANWQRCNVTPCENTECRDTTRYCEKVRQLKLCQLGQFRSRCCGTCGKA
What are the official names of this protein?
ADAMTS-like protein 1, ADAMTSL-1, Punctin-1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: CHEB1_RHOPB
Sequence: MSIAVASASIPEPVRYEPLRVMVVDDSVVIRGLISRWIEAEPDMVVAASLRTGLDAVNQVERVKPDVALLDIEMPELDGISALPQLLAKQRNLIIIMASTLTRRNAEISFKALSLGAADYIPKPESTREASAAEIFRHDLLQKVRSLGARVRRKVQTGPGAVAAPAIVRAREPAPVPAAGHAPAVPLLRRALSLTAPRVLLIGSSTGGPQALMTLVADIGAVIDRFPVLITQHMPPTFTTILAEHLARASRRPAHEGIDGEIIKPGQIYLAPGGKHMRVARQGGNTVIALDDGPAVNFCKPAVDPLFISAIEVWQSAIMAVVLTGMGSDGMRGGKDVVAAGGSVIAQDEASSVVWGMPGAAANAGICAAILPLNQIGQKLVRVFAGDRS
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 1.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AFLR_ASPPA
Sequence: MVDHISPRASPGPIRSSQTRRARKLRDSCTSCASSKVRCTKEKPACARCIERGLACQYMVSKRMGRNPRAPSPLDSTRRPSESLPSAGSEQGLPAHNTYSTPHAHTQAHTHAHSHPQPHPQSHPQSNQPPHALPTPNGSSSVSAIFSHQSPPPLVETQGLGGDLAGQAQSTLSSLTVDSEFGGSLQSMEHGNHADFLAESTGSLFDAFLEVGTPMIDPFLESAPLPPFQARYCCFSLALQTLTCLFPHAPLGCQLRLTDGEDSSCNLMTTDMVISGNKKATDAVRKILGCSCAQDGYLLSMVVLIVLKVLGWYAAAAGTQCTSTAAGGETNSGSCSNSPATVSSGCLTEERVLHHPSMVGEDCVDEEDQPRVAAQLVLSELHRVQSLVNLLAKRLQEGGDDAAGIPAHHPASPFSLLGFSGLEANLRHRLRAVSSDIIDYLHRE
What is the function of this protein?
Involved in the regulation of aflatoxin biosynthesis.  May have a role in nitrate assimilation and sclerotial morphogenesis.
What are the official names of this protein?
Aflatoxin biosynthesis regulatory protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPD_HAEIN
Sequence: MSNLQAIIEAAFEKRAEITPKTVDAETRAAIEEVIEGLDSGKYRVAEKIAGEWVTHQWLKKAVLLSFRINDNQIIDGAETKYYDKVALKFADYTEERFTEEGFRVVPSATVRKGAYISKNCVLMPSYVNIGAYVGEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIGDNCFIGARSEVVEGVIVEDGCVISMGVFIGQSTKIYDRETGEIHYGRVPAGSVVVSGSLPSKCGKYSLYCAVIVKKVDAKTLGKVGINELLRSIEE
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_MACHI
Sequence: MGKYAKNARNPAKSCRARGSNLRVHFKNTRETAKTIKRMPLRRAIQFLKNVQDKQECVPFRRFNGGVGRCAQAKQWGTTQGRWPIKSAQFLLELLRNAESNAEFKGLDSDRLFIEHIQVNRAPCLRRRTYRAHGRINPYMSSPCHIEVILTEKQKYVGKVSHDDSQKKKVSKKKLARQKEKMMRE
What are the official names of this protein?
60S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: HIS7_STRGC
Sequence: MRQAEIKRKTQETDIELAVNLDQQEPVAIETGVGFFDHMLTLFARHSRISLTVKAEGDLWVDSHHTVEDVGIVLGLALRQALGDKAGINRYGTSFVPMDETLGMASLDLSGRSYLVFEADFDNPKLGNFDTELVEEFFQALAFNLQMNLHLKILHGKNSHHKAESLFKATGRALREAITINPEIHGVNSTKGLL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_ACICJ
Sequence: MQIVRNVPDLRAARAALTDGGRARLALVPTMGALHEGHLSLVRAAREAGHVVAASIFVNPTQFGPNEDFTRYPRDPERDCALLAEAGCALAWLPEVSTMYPPGDATSVEVAGLSVVLEGAVRPGHYRGVATVVVKLLGQVRPDAAYFGEKDWQQVQVIRRVAADLFLPVEIVVGPTLREKDGLAMSSRNRYLDPADRARAPLLHQVLRRVRAALRDGEPAAAALAAGRRALAEGGFIVDYLELVDAGTLAPLTAPDDGARLLAAARLGTTRLLDTVAV
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLRA1_RAT
Sequence: MYSFNTLRFYLWETIVFFSLAASKEADAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQDDEGGEGRFNFSAYGMGPACLQAKDGISVKGANNNNTTNPAPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNK
What is the function of this protein?
Glycine receptors are ligand-gated chloride channels.  Channel opening is triggered by extracellular glycine (PubMed:1716350, PubMed:11981023, PubMed:2483325, PubMed:3037383).  Channel opening is also triggered by taurine and beta-alanine (PubMed:1716350).  Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization.  Plays an important role in the down-regulation of neuronal excitability.  Contributes to the generation of inhibitory postsynaptic currents.  Channel activity is potentiated by ethanol (By similarity).  Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).
What are the official names of this protein?
Glycine receptor subunit alpha-1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Synapse. Perikaryon. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein.
Protein: CRE4_CONVL
Sequence: MGFRVLVLVVMATTSALPFTFFEEPGRSPFRPALRSEEAQALRHGLTLLLARRADGQPPDMRQPEMRRPEVRQLEFAELSVGQRRWDVDQCMYYCLTGVVGYSYTECQTMCT
What are the official names of this protein?
Conotoxin vil14.4.
What is the protein family that this protein belongs to?
Belongs to the conotoxin R superfamily.
Protein: SYH_BARQU
Sequence: MSSKQEKTKARLPRGFIDRTSAQLYATETMIAQIREVYELYGFEALETPIFEYTDVLGKFLPDEDRPNAGVFSLQDEDEQWMSLRYDLTAPLARYFAENFEILPKPYRSYRLGFVFRNEKPGPGRFRQFMQFDADIVGTPTVAADAEICMMAADSLEKLGFQHHDYVIRLNNRKILEAVLEQIGLVGREKAEKRLTVLRAIDKLDKFGLEGVRLLLGKGRLDESGDFTKGAQLKDQEIDSVLALLTGEAETAEETLDALRHVVGHHIQGLEGVRELEEMQAIFAANGYQNRIKIDPSVVRGLEYYTGPVFEATLLFDVLNDDGQKVVFGSIGGGGRYDGLVARFRGENVPATGFSIGISRLITALQNLSKLPVKKTPGPVVVLMMDREPEAVAQYQKMVMQLRKAGIRAELYLGASGIKAQMKYADRRQAPCVVIQGSQERQDRKIQIKDLIEGTRLSREIKDNQTWRESRPAQITVDEERLVQAVQDILISQNAQKF
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1058_CHLPN
Sequence: MKLYQTLRGIVLVSTGCIFLGMHGGYAAEVPVTSSGYENLLESKEQDPSGLAIHDRILFKVDEENVVTALDVIHKLNLLFYNSYPHLIDSFPARSQYYTAMWPVVLESVIDEFLMVADAKAKRIATDPTAVNQEIEEMFGRDLSPLYAHFEMSPNDIFNVIDRTLTAQRVMGMMVRSKVMLKVTPGKIREYYRKLEEEASRKVIWKYRVLTIKANTESLASQIADKVRARLNEAKTWDKDRLTALVISQGGQLVCSEEFSRENSELSQSHKQELDLIGYPKELCGLPKAHKSGYKLYMLLDKTSGSIEPLDVMESKIKQHLFALEAESVEKQYKDRLRKRYGYDASMIAKLLSEEAPPLFSLL
What are the official names of this protein?
Protein CPn_1058/CP_0792/CPj1058/CpB1100.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_1058/CT_355/TC_0634 family.
Protein: TRUA_WOLPP
Sequence: MRYKITIEYNGSSFSGWQKQQHSANSIQETIENAIFNFSGERVSLHCGGRTDTGVHALGQVAHFNMERQFELYRIRNGINYHLKAIPIVVLSAEAVDDAFHARFSAKKRYYEYRIINRYAPAALEIGYVWQVFNPLDVNIMREAARHLLGKHNLSSFRSKDCQATNPVRTIDDIDIVQNGSHIYIKISAISFLHNQVRIIVGTLVEFGKNRTNPQEMLNILSQCKRNAAGITAPPHGLYLVKIDY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: ALLC_BACSU
Sequence: MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQLAVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLAAMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDESGVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRRYLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNVANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMDERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTSARQLEIGVRALTDLLYKLAY
What is the function of this protein?
Involved in the anaerobic nitrogen utilization via the assimilation of allantoin (PubMed:11344136).  Catalyzes specifically the hydrolysis of allantoate to yield CO2, NH3 and S-ureidoglycine, which is unstable and readily undergoes a second deamination by S-ureidoglycine aminohydrolase AllE to yield S-ureidoglycolate and NH3 (By similarity).
What are the official names of this protein?
Allantoate amidohydrolase, AAH, Allantoate deiminase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_STRA3
Sequence: MAKKSKIAKFQKQQKLVEQYAELRRELKEKGDYEALRKLPKDSNPNRLKNRDLIDGRPHAYMRKFGMSRINFRNLAYKGQIPGIKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: END3_BUCAP
Sequence: MNKKKRFEILSLFYKKNSNPKIELVFSSDFELLLSVILSAKSTDVMVNKITGTLFQIANTPQSILKLGFNKLRHYIKSIGLYNTKSLNIINSAYLIKTKYNNKVPSNRTELESLPGVGRKTANIILNVLFNKNTIAVDTHVFRVANRTGFAKGKNVIEVEKKMIKIVPSIFKKYVHFWFVLHGRYVCTARQLKCKTCFIEKLCEFDKKK
What is the function of this protein?
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity.  The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site.  The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
What are the official names of this protein?
Endonuclease III, DNA-(apurinic or apyrimidinic site) lyase.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
Protein: YBEY_KLEP7
Sequence: MSQVILDLQLACEETSGLPDEALFQRWVDAVIPPFQEESELTIRLVDVAESHELNLTYRGKDKPTNVLSFPFEAPPGIEMPLLGDLIICRQVVEQEASEQGKPLEAHWAHMVVHGSLHLLGYDHIEDDEAEEMEGLETEIMLALGYEDPYISEKIAE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YKGN_ECOLI
Sequence: MSGKRYPEEFKTEAVKQVVDLGYSVASVATRLDITTHSLYAWIKKYGPDSSTNKEQSDAQAEIRRLQKELKRVTDERDILKKAAVDSICQCNTPFNYLFRCFELQCLSRSVV
What are the official names of this protein?
Putative transposase YkgN.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.