PharMolix/UniProtQA huggingface dataset:
Protein: ACCD_ARAHI
Sequence: MEKSWFNLMFSKGELEYRSGLNKAMDSIENEKTTISKDRFIYDMDKNFYGWGERSSYYNNVDLLVSSKDIRNFISDDTFFVRDSNKNSYSIYFDIKKKKFEINNDLSDLEFFFYSYSYCSSSYLNNRSKSDNDPHYDPYIKDTKYNCNNHINSCIDSYFRSHICIDSHFLSDSNNSNESYIYNFICSESGKIRESKNYKIRTNRNRNNLMSSKDFDITKNYNQLWIQCDNCYGLMYKKVEMNVCEECGHYLKMTSSERIELSIDPGTWNPMDEDMVSTDPIKFHSGEEPYKNRIDSAQKTTGLTDAVQTGIGQLNGIPTALGVMDFKFMGGSMGSVVGEKITRLIEYATNQCLPLILVCSSGGARMQEGSLSLMQMAKISSVLCNYQSSKKLFYISILTSPTTGGVTASFGMLGDIIIAEPYAYIAFAGKRVIEQTLKKAVPEGSQAAESLLRKGLLDAIVPRNPLKGVVSELFQLHAFFPLNKNEIK
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RISB_PSEE4
Sequence: MTLKTIEGTFIAPKGRYALVVGRFNSFVVESLVSGAVDALVRHGVSESDITIIRAPGAFEIPLVAQKVAQQGAYDAIIALGAVIRGGTPHFEYVAGECTKGLAQVSMEFGVPVAFGVLTVDSIEQAIERSGTKAGNKGAEAALSALEMVSLLAQLEAK
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: SRY_HYLLA
Sequence: MQSYASAMLSVFNSDYYSPAVQQNTPALRRSSSFICTESCNSKYPCETGENSKVSVQDRVKRPMNAFIVWSRDQRRKMALENPKMRNSEISKQLGYRWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLQKSCSLLPADSASVLCSKVQLDNRLYRDDCTKATHSRMEHQLGHLPPINTASSPQQQDHYSHSTKL
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: RPPH_PSYCK
Sequence: MIDADGFRANVGIILANTQGQVLWAKRIGHNAWQFPQGGIDRGETPMDAMYRELWEEVGLHPRHVDLLAVTQDWLRYRLPKRYVRHGQYPLCIGQKQKWFLLRLDEPNTQHIRFDEGKPEFDNWQWVSYWYPLGQVIHFKRSVYRRALQELVPELPLQQGLIIPEQNNHLLVE
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: RNPH_RUMCH
Sequence: MLRHDGRSNTQLRSVRILRNYIKHAEGSVLIEVGDTKVICTASVEERIPPFKKDSGEGWVTAEYSMLPRATAVRNQRDISKLKLNGRSSEIQRLIGRSLRTIVDLKLLGERTITIDCDVIQADGGTRTASITGSYVALVDACRTLVKKGLISKMPVTGTVAATSVGIVNGEELLDLCYIEDSNAEVDMNVIKTDKGEFIEIQATGEKSSFSKKQLDQLLNLAESGIHELIKAQNEVLWKD
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: UBID_LEGPL
Sequence: MKYSDLRDFIAQLESRELLKRIDYPVSPHLEMTVVSDKVLRSGGPALLFTNTPNYDMPVLTNLFGTVERVALGMGEESIVALREIGKLLAALKEPDPPKGFKDAFSKLPLLKQALNMAPKYVSGAECQTHVWEKDEVDLTLLPIQTCWPGDVAPLITWGLVTTRGPHQSRENMGIYRQQLLSKNKLIMRWLSHRGGALDYQAWQQEYPKERFPVAVTLGADPATILAAVTPVPDTLSEYAFAGLLRGQRTRLTRCIGNDLHVPASAEIVLEGYLEPGNEAPEGPYGDHTGYYNEVQSFPVFTVERITHRDKPIYHSTYTGRPPDEPAILGVALNEVFIPLLQKQFPEIVDFYLPPEGCSYRLAVVTIKKQYPGHAKRIMMAVWSFLRQFMYTKFVIVCDDDVDARNWQDVIWAMTTRMDPSRDTVMVENTPIDYLDFASPVSGLGSKMGMDATSKWPGETQREWGKPITMDEDVLNRVNGYWSLLGLK
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PUR9_BIFLD
Sequence: MTNTNRPIRRALVSVFHKEGIEVLAEAFVKAGTEVVSTGSTAKKLAELGVKVTEVSDVTGFPECLDGRVKTLHPYIHAGILADMTNPEHAKQLEEFGIKPFDLVVVNLYPFADTVRSGANEADTIEKIDIGGPSMVRGAAKNHATVAIVTDPADYALVASRVADGTGFSLDERKWLAAKAFAHTAAYDATINEWTAKHWPKPASLDAVEVDKDDQGTEVDSAKFPAQFTRTWDRAHTLRYGENSHQQAALYIDPLNQTGFAHAEQLGGKPMSYNNYVDADAAWRTVWDMAPAIAVAVVKHNNPCGLAIGATAAEAHKKAHACDPMSAYGGVIACNSKVTLEMAESVRPIFTEVIVAPDYEPAALELLQTKKKNLRILKVAEPPKGHEAIRQIDGGLLVQDTDLINAVGDDPDAWKLVAGEAADADTLKDLVFAWRAIRCVKSNAILLAHDQATVGIGMGQVNRVDSCHLAVERANTLADGADRATGAVAASDAFFPFADGAQVLIDAGVKAIVQPGGSIRDEEVIEAAKKAGVTMYLTGTRHFFH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: BETA_PSEE4
Sequence: MSKEFDYIIVGAGSAGNTLATRLTEDASVSVLLLEAGGPDYRFDFRTQMPAALAFPLQGRRYNWAYETDPEPFMDGRRMECGRGKGLGGSSLINGMCYIRGNAMDFDGWAELPGLEDWTYLDCLPYFRKAETRDIGPNDYHGGEGPVSVATPKAGNNPLFHAMVEAGVQAGYPRTEDLNGYQQEGFGPMDRSVTKKGRRSSTARGYLDQAKKRPNLTIVTHALSDRVLFDGKRAVGVTYLVGDSEERVEARARKEVIVSSGAIASPQLLQRSGVGPRALLESLDIPVVHDLPGVGENLQDHLELYLQYACTQPVSLYPSLLWWNQPAIGAEWLFNGTGIGASNQFEAGGFIRTRPEFKWPNIQYHFLPVAINYNGSNGVKEHGFQAHMGSMRSPARGRIQAKSKDPRQHPSILFNYMSTEQDWQEFRDGIRLTREIMAQPALDAFRGREISPGAHVQTDEELDKFIREHAETAFHPSCSCKMGTDDMAVVDGEGRVHGMQGLRVVDASIMPLIITGNLNATTIMIAEKISDKIRGRKPLPRSTAKYYVAGDAPVKGKALREVKQA
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: SSRP_COLP3
Sequence: MAKKKSKSSNSNTIALNKKARHNYSLTDKFEGGMSLQGWEIKSIRSGKVNISDCYVHIKDREAYLLGAEISPLNAASSHVVCDPNRDRKLLLNRRELDKIIAAVERDGYSLIATAMYWKACWVKLEFYLGKGKKDHDKRSDIKDREWAVDKGRLMKNKNLDR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: TSP4B_DANRE
Sequence: MAGTMHLLTAVSLILMLSSANAESTVYNLLTSPDCLPDLLHGGLAEQGVTELYILTTFRIQPGTGNTIFSLYNPRDNSKYFEFSVFGKANKAILRYLRRDGRMSAVTFNKLNLADGEKHRLLFHLKGLEVGHPGGFPHSQGALPVPGVELHLDCRLVETLRDLPAVFNGLNNHQAVELKTMQGKAQEGLEELKLAYGDSVENVASLQDCHTQSDSVQALGLNTKQLTTQMLELTKVINELKDVLIQQVKETSFLRNTISECQACGLSGAEVVKPKCAPGVCFRDDMCIETAEGVECGPCPDGYTGDGYSCDDVDECQFNPCFPGVRCVNMAPGFRCEACPLGFTGKPLEGVGVAYAQTHKQVCDDIDECKGPDNGGCTANSICVNSVGSYQCGRCKTGFTGDQIRGCKPEKSCGNRLQNPCDPNAQCTEERDGTITCQCGIGWAGNGYLCGKDTDIDGYPDERLRCRDPTCRKDNCVTVPNSGQEDADGDGKGDACDPDADGDGILNEQDNCWLTPNINQQNSDKDSHGDACDNCVRVDNPDQRDTDSDGLGDACDDDMDGDGLKNFLDNCQRVKNRDQLDRDGDGVGDACDSCPDIPNPNQSDIDNDLVGDSCDTNQDSDGDGHQDSKDNCPMVINSSQLDTDKDGIGDECDDDDDNDGIPDSLPPGPDNCRLVPNPEQIDDNNDGVGDICESDFDQDKVIDRIDNCPENAEITLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFSGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVKSKTGPGEHLRNSLWHTGDTNDQVRLLWKDPRNVGWKDKVSYRWYLQHRPQVGYIRVRFYEGTELVADSGVTIDTTMRGGRLGVFCFSQENIIWSNLKYRCNDTIPEDFQEFSTQHGMDPL
What is the function of this protein?
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment.  May play a role in ER stress response (By similarity).
What are the official names of this protein?
Thrombospondin-4-B, Thbs4-B.
What is the protein family that this protein belongs to?
Belongs to the thrombospondin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Sarcoplasmic reticulum. Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix.
Protein: RGPA2_HUMAN
Sequence: MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYENFIALENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTGNSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVMSSRGPCTLETLINPSPSVADVKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTGFKFLFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYITTTRDNENIYSTKIPYMAARVVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAVQERAPELDGGGPTEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAFLLPSCEIAVTRKVVQVYRKWILQDKPVFMEEPDRKDVAQEDAEKLGFSETDSKEASSESSGHKRSSSWGRTYSFTSAMSRGCVTEEENTNVKAGVQALLQVFLTNSANIFLLEPCAEVPVLLKEQVDACKAVLIIFRRMIMELTMNKKTWEQMLQILLRITEAVMQKPKDKQIKDLFAQSLAGLLFRTLMVAWIRANLCVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCVLDPQKGTTVGRSFSLSWRSHPDVTEPMRFRSATTSGAPGVEKARNIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVADADARHWLQLSPTDASNLTDSSECLTDDCSIIAGGSLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHARVFCYLYELWYKLAKIRDNLAISLDNQSSPSPPVLIPPLRMFASWLFKAATLPNEYKEGKLQAYRLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDILNTIIRHCPPRFFSLGFPGFSMLVGDFITAAARVLSTDILTAPRSEAVTVLGSLVCFPNTYQEIPLLQSVPEVNEAITGTEDVKHYLINILLKNATEEPNEYARCIAVCSLGVWICEELAQCTSHPQVKEAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVAFLLPSAEYSSVETDKKFIVSLLLCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYIYRVLHCCVCGSSTYTQQSHYILTLADLSSTDYDPFLPLANVKSSEPVQYHSSAELGNLLTVEEEKKRRSLELIPLTARMVMAHLVNHLGHYPLSGGPAILHSLVSENHDNAHVEGSELSFEVFRSPNLQLFVFNDSTLISYLQTPTEGPVGGSPVGSLSDVRVIVRDISGKYSWDGKVLYGPLEGCLAPNGRNPSFLISSWHRDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSLTPCGMNYDQEKEIIEVILRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGAIVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPSPSYSLSGTD
What is the function of this protein?
Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
What are the official names of this protein?
Ral GTPase-activating protein subunit alpha-2, 250 kDa substrate of Akt, AS250, p220.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCID2_DANRE
Sequence: MAHITLNQYLQQVLEAIDSRDGSFCAEMMSFKHPHVANPRLQLSSPEEKCQQLLEPPYDEMVAAHLRCTFAVSNHDFVEAYKCQTVVVQSFLKAFQAHKEENWALPIMFAVTLDLRIFANNAEQHLQQKGKGKVGDMLEKAAEQLMSCFRVCASDNRAGIDDSKKWGMLFLINQLFKIYFKINKLHLCKPLIRAIDSSNLKDEYTMAQRVTYKYYVGRKAMFDSDFKPAEECLSFSFTHCHRSCQRNKRLILIYLLPVKMLLGHMPTHQLLKKYDLMQFADVTRAVSEGNLLLLNAALVKHETFFIRCGIFLILEKLKIITYRNLFKKVYHLLRTHQLPLAAFLVSLQMTKVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSSIS
What are the official names of this protein?
PCI domain-containing protein 2, CSN12-like protein.
What is the protein family that this protein belongs to?
Belongs to the CSN12 family.
Protein: GPDA_ECOL6
Sequence: MNQRNASMTVIGAGSYGTALAITLARNGHEVVLWGHDPEHIATLERDRCNAAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFGEVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDQTFADDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVQSAQEKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKDERSSH
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UGPB_YERE8
Sequence: MFNNAIRKTSICVALTLAFSANAMAVTEIPFWHSMEGELGVEVNSLADRFNQSHSDYKIVPVYKGNYEQSLAAGIAAFRSGKAPAILQVYEVGTATMMASKAIKPVFQVFKDANINFDESVFVPTVAGYYTDAKTGHLLSQPFNSSTPVLYYNKDAFKKAGLNPDQPPKTWQELAEDTAKLRAAGSSCGYASGWQGWIQIENFSAWHGQPIASRNNGFDGTDAVLEFNKPLQVKHIQLLSDMNKKGDFTYFGRKDESTAKFYNGDCAITTASSGSLADIRHYAKFNYGVGMMPYDADAKDAPQNAIIGGASLWVMDGKDKDTYKGVAEFLQFLTQPEIAAEWHQKTGYLPITTAAYELTKQQGFYDKNPGADVATRQMLNKPPLPYTKGLRLGNMPQIRTVVDEELEGVWTGKKTPQQALDTAVSRGDVLLHRFEQTNK
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Binds G3P.
What are the official names of this protein?
sn-glycerol-3-phosphate-binding periplasmic protein UgpB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CBLA_DICDI
Sequence: MNRATITSNKSNAPSFLSIPLLAHNNNINNNNNNINNNNNNNNINSNNNGTTTTTTTTTITTISYKNNISELITIIDKIIKDLNNFKSKTVLNDQEFSELNNTIQFTKTSLVNYIHYENENKINFNLSDSKIICSEIKIIEYGIESFIFSICKLYQDLIQFQQLLLKLSSPPTTITFNTTINSTNSFTSNLIINNLLKVDSILKQSIDQLLALFPPSSSSLNNENNNNNNNNYNPYELLSNEAKVLWNQFGGNKITFVPWSIFFKGFQKFFNKEILAYESSLRYTLDFTRDGYVTPFKLSVFIKWFGALPVSLGIFQDVINSKIFSGFISGIEATQLLSRQQVGYYLLRCSKTIVGAFAITFVDSTNHIRHCLLYPVTSSINGGLTLQKPPDIFKSILSFILSFSSKLKYPIGPLDNDLLPPLSIINNNPILILPDENNNNQNNNQNNNNNNINTFSTSPSSFFTIDSSNSSDTNKSPTKSRKSSFKNDKDKKEKEKEKGKDKEKEKERVSDENFDNLPTFLNSEDENDNNNNNNNNNNNNNNNNNNNNNNNNNNSSNNNNCNIKETHQTTSNGSSGNNNNNNNNNNNNNNNNNNNNSSSTTKRNNNNNGSDESKDLCTVCMDNEINTVFLECGHLSCCSLCSVKLKKCPICRSRITRVINIFKS
What is the function of this protein?
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome.  Up-regulates STATc tyrosine phosphorylation via an inhibitory effect on ptpC accumulation.  Recognizes activated receptor tyrosine kinases, RTKs and terminates signaling.
What are the official names of this protein?
E3 ubiquitin-protein ligase cblA, Cbl-like protein A, RING finger protein cblA, RING-type E3 ubiquitin transferase cblA.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=A very small proportion appears to be nuclear but this may reflect cytoplasmic contamination of the nuclei.
Protein: GSH1_YERE8
Sequence: MIPDVSHALTWLEAHPKALKGIRRGIERETLRVTADGQLASTGHPESLGAALTHQWITTDFAEALLEFITPVDGDIDHLLTFLRDIHRYTARKLGDERMWPLSMPCFIGAEQDIELAKYGSSNIGRFKTLYREGLKNRYGALMQTISGVHYNFSLPLEFWQAWAGVTDEKSGKEEISAGYFRLIRNYYRFGWVIPYLFGASPAICASFLQGRETALPFERNDKGMCYLPYATSLRLSDLGYTNKSQSNLGITFNDLHTYVAGLKRAIQTPSEEYAALGLKDGDRHLQLNTNVLQIENELYAPIRPKRVTRAGESPSDALLRGGIEYIEVRSLDINPFSPIGVDAVQARFLDLFLIWCVLADAPEMSSDELLCTRKNWNRVILEGRKPGQTIGMGCNDTREPLEKVGKDLFTDLRRVAEVLDGKDSTEYQQVCDELVASFDDPSLTFSARILQAMKEGGIGGVGLELAERYREMLQNEPLELLTEEQLSEEGAASWVRQRELELKDKLSFEEYLALHGGQ
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: EED_MOUSE
Sequence: MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
What is the function of this protein?
Polycomb group (PcG) protein.  Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene.  Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity).  The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity).  Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.  Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males.  Required for stable maintenance of XCI in both embryonic and extraembryonic tissues.  May prevent transcriptional activation of facultative heterochromatin during differentiation.  Required for development of secondary trophoblast giant cells during placental development.  May regulate hippocampal synaptic plasticity in the developing brain.
What are the official names of this protein?
Polycomb protein EED.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ESC family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in cells of the early embryo and in stem cells of the extraembryonic trophectoderm lineage. Recruitment to the inactive X-chromosome requires XIST.
Protein: APBA2_PONAB
Sequence: MAHQKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEEYLAHGAHPVDTDECQEAVEEWTDSAGPRPHSHEAEGSQDYPDGQLPIPEDEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTSASPYRLRRGDRDLEDQEEDIDQIVAEIKMSLSMTSITSASEASPEHGPEPGPGDSAEACPPIKASCSPSRHEARPKSLNLPPEAKHPGDPQRGFKPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISAQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI
What is the function of this protein?
Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery.  May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity).
What are the official names of this protein?
Amyloid-beta A4 precursor protein-binding family A member 2.
Protein: H17B6_BOVIN
Sequence: MWLYLAVLLGLYYLLRWFRERQVVSHLQDKFVFITGCDSGFGNQLARQLDLRGLRVLAGCLTEQGAEQLRNQTSDRLQTVILDVTKTESIAAATEWVKECVGDRGLWGLVNNAGIFHSHGYAEWIKIETYRDTLRVNLIGVIEVTLSMLPLVRKAQGRIVNVSSILGRIAFFGAVYSCSKYGVEAFSDILRRELQHFGVKVSMVEPGYFRTAMTDWQKFSEIMKQIWKETPAHIKETYGQKFFDAYHDLMKQGLLSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFVPLSYLPTSLADYILTRSWPKPAQAV
What is the function of this protein?
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro).  Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro).  Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro).  Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro).  Has retinol dehydrogenase activity towards all-trans-retinol (in vitro).  Can convert androsterone to epi-androsterone.  Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone.  Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity).
What are the official names of this protein?
17-beta-hydroxysteroid dehydrogenase type 6, 17-beta-HSD 6, 17-beta-HSD6, 3-alpha->beta-hydroxysteroid epimerase, 3-alpha->beta-HSE, Oxidative 3-alpha hydroxysteroid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Microsome membrane; Peripheral membrane protein; Lumenal side. Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Protein: YCCT_SALPA
Sequence: MKTGALATFLALCLPVTVFATTLRLSNEVDLLVLDGKKVSSSLLRGAESIELENGPHQLVFRVEKTIRLPGNEERLYISPPLVISFDTQLISQVNFQLPRLENEREASHFNAAPRLALLDGDAMPIPVKLDILAITSTAKVVDYEIETERYNKSAKRASLPQFATMMADDSTLLSDVSELDTVPPQSQTLTEQRLKYCFRLADPQTRHHFLQWAEKQPPS
What are the official names of this protein?
UPF0319 protein YccT.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.