PharMolix/UniProtQA huggingface dataset:
Protein: LAMB_YEREN
Sequence: HFHGYARSGIGWTGSGGEQQCFKTTGAQSKYRLGNECETYAELKLGQELWKEGDKSFYLDTNVAYSVSQRDDWESTDPAFREANVQGKNLIESFPGSTMWAGKRFYQRHDVHMIDFYYWDISGPGAGLEAIDLGFGKLSVAATRNSEAGGSSAWINNQRKDADKTINDVYDIRLAGLETNPGGSLEFGVDYGRANTQDDYSLAPNASKDGVLLTAEHTQSMMGGFNKFVVQYATDSMTSWNSGHSQGTSVNNNGHMLRVIDHGAINLAEKWDMMYVALYQDTDWDNNNGTTWYSVGVRPMLQMELPIMSTLLEIGYNNVKSQRTGKRNGQYKLTLAQQWQAGDSIWSRPATRVFATYANWDEKWGYNNVDKSPDNGLAQNGTIGTDSRGKSNECTFGAQF
What is the function of this protein?
Involved in the transport of maltose and maltodextrins.
What are the official names of this protein?
Maltoporin, Maltose-inducible porin.
What is the protein family that this protein belongs to?
Belongs to the porin LamB (TC 1.B.3) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: TMP_BPLC2
Sequence: MAKEKYVIQAELETKGVLSNAREAQREINNIGRLAKETNKNAQITGSVTMKDKGIKETQRALNLAKQNVDNLTKALANAKMSGATQKQVQALESQLVKAQTQATRLSTELAKVGSEKGTGLSGAVDKMKSAGGSLLGTFSKVGNVVSGISSAIGLVSGGISKAVDLTSGFANTLMDTYDKQIQAQKTLSTTLSDGAKGYEQFNGHIDKGNSLLKSQKTDLNELGATISSYMKVSGDEAFKTVNAINAVGDSLGLGMDTQKQFTYGLAQALGSGTLHAQDFNQMMQSALGAQFRDMLIQAANEMQNVGMTAEQLPDALKKGKVEADLLANTFGDNWASKMAKAQTSLKGIEVSTGGVKRMLKDGQLSVQDFTNVFGDGFTSSLLNAMNTTSDGAVTMENFKDKMEDGVFSTEVMNRAIELFQQKGEKLASSGPSTWAQIREMISNGFNTSALDGFRKGLGDTGLDMSSMGNNATEMSSIVGSKLGQMAGQAVGALTKIIDKNKDGKVSNEEMEGAVNDAKDAVTNFFNKINFTSIQGFLGKIGNAIDELVRFYNWANDAYGAVQNLLSASRQVGGNTGLIGKALGFRKNSTWGDAFSDFHWLTSNIDPLGLKENQGLGQKLLGSRNGQIPLDLQFFAGGREAINKAVDAVQPYARASKGTTATSSIGTQDNSKQDIKIYVQSSADGQRIAKEIYNKLERNGVKLNKR
What is the function of this protein?
Serves as a base for tail tube protein polymerization and acts as a template for tail length determination.
What are the official names of this protein?
Probable tape measure protein, TMP, Gene product 110, gp110.
What is the protein family that this protein belongs to?
Belongs to the Mulikevirus tape measure protein family.
Protein: LEU1_HAEIE
Sequence: MTDRVIIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSQGDFESVQTIARHIKNARVTALSRAVDKDIDAAYEALKVAEAFRIHTFIASSALHVEAKLKRSFDDVVGMAVAAVKRARNYTDDVEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDTVGFCLPNEYGNIIAQVRNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTSLEEVVMAMKVRQDFMGVDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMLKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNEQDYDLDKLYDAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEYPATAFVQLKLDGNKLITSSIGGNGPVDAVYNAILNLTGLEIKMSHYNLTAKGEGAEALGQVDIVVEHKGRKFHGVGLATDIVESSALALVHAINAIYRAHKVADIKNHKHH
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: ASSY_DESVV
Sequence: MSGIKKVVLAYSGGLDTSVILKWLAVTYNCEVVTLTADLGQEEDLDGVDDKAMRTGASRAYVEDLQEEFARDFIFPMMRAGAVYEGRYLLGTSIARPLIAKRLVEIARAEGAQAVAHGATGKGNDQVRFELAVNALAPDLRVIAPWREWDLRSRTQLNAFAEEHGIPISNSAKQYSMDRNMLHCSFEGGELEDPWNEPGPNSYVMAVPMEQAPDEAEYISIDFEHGNPVAVNGERLSPAALVKKLNSIGGRHGIGRLDMVENRFVGIKSRGVYETPGGTLIHIAHRDLEGICIDRETMHLRDAMLPRYAAAIYNGFWFAPEREAMQAMIDVSQQRVTGTVRLKLYKGNAWPVGRQSPNTLYCHDLATFEDCATYDHKDAAGFIKLQGLRIRGYKKG
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSN_BOVIN
Sequence: MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGAGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLESETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACVEK
What is the function of this protein?
Exhibits both single-stranded and double-stranded endoribonuclease activity.  May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand (By similarity).
What are the official names of this protein?
Translin, Component 3 of promoter of RISC, C3PO.
What is the protein family that this protein belongs to?
Belongs to the translin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LLPB_NOTEU
Sequence: MKVLFLTIALSLFSILQAQDSSSSEEQFEGTYFVKAIVTDSEFFEKNKPKALSPLTVTHLSNGDLEAKFTTNMNGICEEIKMKFEKTDKPGIFSTNDGSRQVLIEKTSVRDHWILFCEGELHGMQVRIAKLLGPHTDENPKAFQEFKKFVSLKRFNEEKINIPRQTETCIPEHV
What is the function of this protein?
Probably serves a role in the transport of a small ligand released during the hydrolysis of milk fat.
What are the official names of this protein?
Late lactation protein B, LLP-B.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_BACFR
Sequence: MYLDAAKKQEIFSKYGKSNTDTGSAEAQIALFSYRITHLTEHMKLNRKDYSTERALTMLVGKRRALLDYLKAKDITRYRDIIKELGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: DGKH_MOUSE
Sequence: MAGAGSQHHPQGVAGGAVAGASAVSPTAAGPGEDSSDSEAEQEGPQKLIRKVSTSGQMRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEVWISSLKSVQSREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDVYHPVCPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPYLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLHKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPAKSSLLPEPVAATEEFYMTIYEDSVANHLTKIVNSDEHAVVISSAKILCETVKDFVAKVEKAQDRTLENTVVAEAVASKCSVLNEKLEQLLQALHADSQASRVPPGIGPAIPEEDTVESASDESLGESKDQLVNDIGKPSSQKAVKPREIMLRANSLKKAVRQVIEEAEKVMDEPAVQPSEPVSPSCDYDTETDEAKEDDAKESLSAKTTSQSPDAQASCGHPQTDSVAGPAMATTKENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSLDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAVFDSVQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPVLRTNLYIHPAPDLATEEVSQMRLCSQAAEELITRICDAATIHCLLEQELAHAVNACSHALNKANPRFPESLTRDTATEIAINVKALYNETEALLVGRVPLHLESPHEERVSSALHSVEMELQKLTEIPWLYYILRPSEDEEPPLDCTKRNNKSTVFRIVPKFKKEKAQKQKTSSQPVQNWGTEEVAAWLDLLNLGEYKEIFIRHDVRGAELLHLERRDLKDLGIPKVGHMKRILQGIKELERNPPNLV
What is the function of this protein?
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:27643686).  Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable).  Plays a key role in promoting cell growth.  Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF.  Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (By similarity).
What are the official names of this protein?
Diacylglycerol kinase eta, DAG kinase eta, Diglyceride kinase eta, DGK-eta.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS.
Protein: LPLA_ECO81
Sequence: MSTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTSIVLNALNALGVSAEASGRNDLVVKTAEGDRKVSGSAYRETKDRGFHHGTLLLNSDLSRLANYLNPDKKKLAAKGITSVRSRVTNLTELLPGITHEQVCEAITEAFFAHYGERVEAEIISPDKTPDLPNFAETFARQSSWEWNFGQAPEFSHLLDERFTWGGVELHFDVEKGHITRAQVFTDSLNPAPLEALAGRLQGCLYRADMLQQECEALLVDFPEQEKELRELSAWIAGAVR
What is the function of this protein?
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
What are the official names of this protein?
Lipoate-protein ligase A, Lipoate--protein ligase.
What is the protein family that this protein belongs to?
Belongs to the LplA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACUC_STAAC
Sequence: MQQHSSKTAYVYSDKLLQYRFHDQHPFNQMRLKLTTELLLNANLLSPEQIVQPRIATDDELMLIHKYDYVEAIKHASHGIISEDEAKKYGLNDEENGQFKHMHRHSATIVGGALTLADLIMSGKVLNGCHLGGGLHHAQPGRASGFCIYNDIAITAQYLAKEYNQRVLIIDTDAHHGDGTQWSFYADNHVTTYSIHETGKFLFPGSGHYTERGEDIGYGHTVNVPLEPYTEDASFLECFKLTVEPVVKSFKPDIILSVNGVDIHYRDPLTHLNCTLHSLYEIPYFVKYLADSYTNGKVIMFGGGGYNIWRVVPRAWSHVFLSLIDQPIQSGYLPLEWINKWKHYSSELLPKRWEDRLNDYTYVPRTKEISEKNKKLALHIASWYESTRQ
What is the function of this protein?
Role in growth on acetoin or butanediol.  Involved in the breakdown of these compounds used as a carbon source (By similarity).
What are the official names of this protein?
Acetoin utilization protein AcuC.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family.
Protein: COX2_GORGO
Sequence: MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTSTNISDAQEMETIWTILPAIILVLIALPSLRILYMTDEINDPSFTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPVEAPVRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFAL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ENAH_MOUSE
Sequence: MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQEAAQSKVTATQDSTNLRCIFCGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERMERERLERERLERERLERERLEQEQLERQRQEREHVERLERERLERLERERQERERERLEQLEREQVEWERERRMSNAAPSSDSSLSSAPLPEYSSCQPPSAPPPSYAKVISAPVSDATPDYAVVTALPPTSTPPTPPLRHAATRFATSLGSAFHPVLPHYATVPRPLNKNSRPSSPVNTPSSQPPAAKSCAWPTSNFSPLPPSPPIMISSPPGKATGPRPVLPVCVSSPVPQMPPSPTAPNGSLDSVTYPVSPPPTSGPAAPPPPPPPPPPPPPPPLPPPPLPPLASLSHCGSQASPPPGTPLASTPSSKPSVLPSPSAGAPASAETPLNPELGDSSASEPGLQAASQPAESPTPQGLVLGPPAPPPPPPLPSGPAYASALPPPPGPPPPPPLPSTGPPPPPPPPPPLPNQAPPPPPPPPAPPLPASGIFSGSTSEDNRPLTGLAAAIAGAKLRKVSRVEDGSFPGGGNTGSVSLASSKADAGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDRNEDAEPITAKAPSTSTPEPTRKPWERTNTMNGSKSPVISRPKSTPSSQPSANGVQTEGLDYDRLKQDILDEMRKELAKLKEELIDAIRQELSKSNTA
What is the function of this protein?
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells.  ENAH induces the formation of F-actin rich outgrowths in fibroblasts.  Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation.
What are the official names of this protein?
Protein enabled homolog, NPC-derived proline-rich protein 1, NDPP-1.
What is the protein family that this protein belongs to?
Belongs to the Ena/VASP family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, filopodium. Synapse. Cell junction, focal adhesion. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity).
Protein: RL28_BACAH
Sequence: MARVCAITGRKARSGNSRSHAMNATKRKWGANLQKVRVRIDGKVQRVYVSARALKSGKIERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: SYGA_PROMA
Sequence: MNFQDIISSLNSFWSNQGCVLLQPYDTEKGAGTMSPHTILRAIGPEPWSVAYVEPCRRPTDGRYGENPNRAQHYYQYQVIIKPSPDEIQEKYLSSLEALGIKQEQHDIRFVEDNWESPTLGAWGVGWEVWLDGMEVTQFTYFQQCGGLDCRPVSIEITYGLERIAMYLQDVKSIWDLRWNDSYSYGDIWLPYEKSNCKFNFEGSNPERLFKLFDLYEEEAKSLLNKRLSSPALDFVLKCSHTFNLLEARGVISVTERTATIARIRNLARKVAELWLEERKNIGFPLLKNSQTSKNS
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHLB_VIBVU
Sequence: MKKTHITEQKFADLGLNPQVVEGLEKKGFEFCTPIQALALPVLLSGQDIAGQAQTGTGKTLAFLTATFNHLLTTPAHEGRQPTQPRAIIMAPTRELAIQIYNDAEPLIASTGIKAALAYGGESYDKQLTKLQGGVDVLIGTTGRIIDFYKQRVFNLNNIQAVVLDEADRMFDLGFIKDIRFLFRRMPAPQERLNMLFSATLSYRVQELAFEHMHNPEHVVVEPEQKTGHRIQEELFYPSNEDKMALLQTLIEEEWPDRAIIFANTKYKCESIWAHLAADGHRVGLLTGDVPQKKREKILEQFTQGSVDLLVATDVAARGLHIPQVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISFACEDYAINLPAIEEYIEHTIPVSDYDSSALIQDLPAPVRTPSARNQQRRTNTGGARSGDRKSNNRRPRQPRQHKEA
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPH_MOUSE
Sequence: MLRLCFFISFMCLVKSDTDETCPSFTRLSFHSAVVGTGLSVRLMLYTQRDQTCAQIINSTALGSLNVTKKTTFIIHGFRPTGSPPVWIEELVQSLISVQEMNVVVVDWNRGATTVIYPHASSKTRQVASILKEFIDQMLVKGASLDNIYMIGVSLGAHIAGFVGESYEGKLGRVTGLDPAGPLFNGRPPEERLDPSDALFVDVIHSDTDALGYKEALGHIDFYPNGGLDQPGCPKTIFGGIKYFKCDHQMSVYLYLASLQNNCSITAYPCDSYRDYRNGKCVSCGAGQIVPCPRVGYYADSWKEYLWDRDPPMTKAFFDTAETKPYCMYHYFVDIVSWNKSVRRGFITIKLRGEDGNITESKIDHEPSAFEKYHQVSLLARFNRDLDKVAEISLLFSTGSVVGPKYKLRVLQMKLRSLAHPDRPHLCRYDLVLMENVETSFQPILCSQQQM
What is the function of this protein?
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid (By similarity).  Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) (By similarity).
What are the official names of this protein?
Lipase member H.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted. Cell membrane; Peripheral membrane protein.
Protein: RECU_STRZJ
Sequence: MVNYPHKVSSQKRQTSLSQPKNFANRGMSFEKMINATNDYYLSQGLAVIHKKPTPIQIVQVDYPQRSRAKIVEAYFRQASTTDYSGVYNGYYIDFEVKETKQKRAIPMKNFHPHQIQHMEQVLAQQGICFVLLHFSSQQETYLLPAFDLIRFYHQDKGQKSMPLEYIREYGYEIKAGAFPQIPYLNVIKEHLLGGKTR
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_PROMM
Sequence: MSIGILGKKLGMSQFFDDQGRAIPVTLIEAGPCRITQLKTSEIDGYAAVQIGFGDTREKLINKPSKGHLTKSGEVLLKHLREYRVEGLEGLELGAAITVGSFEAGQKVDVSGDTMGRGFAGYQKRHGFSRGPMSHGSKNHREPGSTGAGTTPGRIYPGKRMAGRYGGKKRTTRGLTILKVDSNRNLLVVKGSVPGKPGALLNIRPAKRVGNKPAQGGK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: Y1584_METJA
Sequence: MEIGNKVMEMKNDISKWKLIKTLYKVLKLKCWYDDENYAWSGGLSAYADGLRLLSKVGLFKIESEYCRSVTGKFKELKASAVNLNAVDEDELIETLYRVLRQSCIMNIDDNIGESFGKKVYASGLRLLSKLGLFEIESEQGDYIIGKFKEI
What are the official names of this protein?
Uncharacterized protein MJ1584.
Protein: METK_STRPF
Sequence: MSERKLFTSESVSEGHPDKIADQISDAILDAILAEDPEAHVAAETCVYTGSVHVFGEISTTAYIDINRVVRDTIAEIGYTEAEYGFSAESVGVHPSLVEQSGDIAQGVNEALESREGDTDDLSHIGAGDQGLMFGFAINETPELMPLPISLSHQLVRRLAELRKSGEISYLRPDAKSQVTVEYDEHDKPVRVDTVVISTQHDPEATNDQIRQDVIEKVIKDVIPADYLDDDTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNLVAAGLATKAEVQLAYAIGVAQPVSVRVDTFGTSTVPEAVLEAAVRQVFDLRPAGIIQMLDLKRPIYKQTAAYGHMGRTDIDLPWERLNKVDALVEAVKTVL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BDS3B_BUNGR
Sequence: MSARRFLFLLVVTSLIAASLAAPKDVQMTKRGTPCWCGQTKGVYWYWMRKCPSGYGYTGNCYHFMGRCCYPAGS
What is the function of this protein?
Potently and selectively inhibits voltage-gated potassium channels Kv11/KCNH/ERG.  Acts as a gating-modifier toxin that shifts the voltage-dependence of ERG activation in the positive direction and suppresses its current amplitudes elicited by strong depolarizing pulses that maximally activate the channels.
What are the official names of this protein?
U-actitoxin-Bgr3b, U-AITX-Bgr3b, U-AITX-Bg1c.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: IF2_METSB
Sequence: MSETKNPGDHTLSVSPTKTLSLKRPVEAGIVRQSFSHGRSKAVVVEKVKRRALGEPHVLRESAPALDVVAPAPQAAPPAPTQQPQPRVASRPQPQQRSSSGVILRSLTEEEREARSRALSGAHEREVEERKRAEIEAKARDEREAREREERAAAEARKREEETRRLQEAESKRRSESEAKRRLAGGEPAPAGANAAPRKAPALSAAPGSAAPSGQPGPAGAVGARPAEEEDAAKRIIRRPGMPTKVIVARPVKGAEQKSRGRLTVASATGDEEERTRSIAAFRRRTQRLKGHVSETKEKLSREVVLPETITIQELANRMSERAVDVIKLMMKQGQMAKITDVIDADTAQLIAEELGHTVKRVAESDVEEGLFDSPDVEEHLISRPPVVTIMGHVDHGKTSLLDALRHANVVSGEAGGITQHIGAYQIVASNGLPITFIDTPGHAAFTAMRARGAKVTDIVVLVVAADDGVMPQTAEAISHAKAAGVPIIVAINKIDKPDAKPERVRQELLQYEVQVESLGGDTLEVEVSATKKINLDKLADLIALQAELLDLKASPDRPAEGTVIEARLDKGRGPVATVLVQRGTLKVGDLIVGGSQWGKVRALIDDKGVNRQEAGPSMPVEVLGFSGSPEAGDRVGVVENEARAREIAAYRDRQKREQAAARGNLARGSLADMMSQLKTAARKEFPLVIKADVQGSLEAIVATLEKLNTDEVAARIIHAGVGGITESDVTLAEASGAVLIGFNVRAHKEGRQLAEQQGLEIRYYNIIYNLVDDVKAAMSGLLAPTLREDMLGNAEILEVFHISKVGKVAGCRVTDGRVERGANVRLIRDNVVVHEGKLSTLKRFKDEVKEVVAGQECGMAFEHYQDMRVGDVIECYRVEEIQRTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROL_SALPA
Sequence: MMQPLYLVGPRGCGKTTIGMALAQATGFRFADTDRWLQSHVQMSVADIVEKEGWGGFRARETAALEAVSAPSTVVATGGGIILTEYNRRYMHRVGVVIYLCAPVSTLVNRLEAEPEADLRPTLTGKPLSEEVREVLEQRDALYRETAHYIIDATKAPAQVVSEIIAALPPSTQRLQGDVYT
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_KLEAE
Sequence: ATGWSAFFIDGKWTEAKK
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.