PharMolix/UniProtQA huggingface dataset:
Protein: LEU3_WOLSU
Sequence: MKKYEIAIIKGDGIGPEIVDEAKKVLDAISYSHGFELSYHDYLMGGIAVDRAGVPLPDETIEGCLRADAVLFGAIGGEKWDSLPRELRPESGLLKLRKSLEIFANLRPTVVYDELIEASTLKESVIKGVDILVVRELIGGIYFGEPKGREGDKAFNTMVYSVPEIERIAHVAFKAAMRRQKRVCSVDKANVLDVSQLWRETVTRIAKEYPEVELSHMYIDNAAMQLIRNPKQFDVILTGNLFGDILSDEASMLSGSIGLLPSASIGGKAALYEPIHGSAPDIAGQGIANPIATIASASMMLRHSLGEVEAADAIDKAIVKTLKEGYRTKDIAAFGAKEICTTDEMGSIIANYAAKKGE
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_LISW6
Sequence: MSKIPVIVIVGPTAVGKTSLSIELAKKLDGEIISGDSMQVYRGLDIGTAKITSEEMCGIKHHLIDVTDASVPFTAAKFQSETMALIESIHSRGKLPIIVGGTGLYIQSVFYDYDFGNSSEDKAFRAKLDSLDKVTLWKMLEQQDPESAKLIHENNKRRVIRALEVIHLTGKPFSEYQVHHKLNDMYKPLFLGLDLDRALLYERINQRVDIMFEQGLVSEAKKLYDENLADVPAIRGIGYKELFTYFEGNSTLEEAKELIQKNSRHFAKRQLTWFRNRMEINWIQAGTSSTETEAMNKVKTFLASK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: AROQ_CAMJ8
Sequence: MKIMIIQGPNVNMLGVREVGIYGAMKMEEIHEQMKLAASQNNVELDFFQSNFEGEIVDKIQECLGTVDGIIINAAGYTHTSVAIRDAIAAVALPTIEVHISNVYRREEFRQKSLIAPVCSGTIVGFGPFGYHLALMGIIQICEQIKNLRAMQQAQQTNK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: PTAR2_PESFW
Sequence: MEAADPNNNLTITSPSTLLSNPTQPPAQPLKLRDSCHACASSKVKCHKEKPTCSRCRKRGITCEYFAHRRPGRKQENRAKDTTNHVERQENTTAVEMLDLNWPAPDFSTQTSIANDNLDVFHDIFVPPDQLNNGLTDFTIDFDDFDIQSDPAEIASLPDTSSLESMFVTSPTAPTDTITPNVITPNVGLSVLEGLPDTTHHTQAINLASYIQTPPTEKTPDSRIKHLEENKDPCMTRALSFLTQLSESTSRICKTSETGCSGTNKKSLPESLDGIIAENRRLLEAMSNILQCRCSEDDDLLCIQAIVASKILNLYASAIEIKPSPARVGSGVSTHTTAGQYEPQVEQQLSTRTHPQLASGRDPIRMAAQSVLGELHRVQRLLSQMLQKSKDNETMRRKGSENGLRAVADKVPLTSGVSFGSIEADLRYKLGKLSIEIITLLRGA
What is the function of this protein?
Transcription factor that, with ptaR1 and ptaR3, coregulates the expression of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes (PubMed:24302702).
What are the official names of this protein?
Pestheic acid cluster transcriptional regulator 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYT_CAMLR
Sequence: MTKDIIAYANNETLVDTQSFNNDTNLTPIYFDNSKESLEVIRHSCAHLMAQAIKSLYPEAKFFVGPVIEDGFYYDFRVDSKISEEDLSKIEKKMKELAEAKLDITKYELSKAEVKEKFANDDLKQEVLLRIPDGKVSIYKQGEFEDLCRGPHVPNTKYLRFFKLTRVAGAYLGGDEKREMLTRIYGTAFADKESLNEYLKIIEEAKKRDHRKLGNEMKLFAFDDEIGGGLPIWLSNGAKLRSKLEHLLYKAHRLRGYEPVRGPELLKADAWKISGHYANYKENMYFTQIDEQEYGIKPMNCVGHIKIYQSDVRSYRDLPLKFFEYGVVHRHEKSGVLHGLFRVREFTQDDAHIFCMPSQIKEQVLEILSFVDTLMKAFGFDYEMEISTRPAKAIGDDEIWDIATNALKQALDEQGLKYGIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDFNLPSRFKLEYTDADNEKKQPVMLHRAILGSFERFIGILIEHCAGELPFFIAPTQVAIVPISQNHHEYAKEIAKKLLELGIDSEVYSKNESLNKKIRTAEKAHVPMILVLGDEEVANKSVALRDRRAKEQKTLTLDEFITLTKEKLSEVRF
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_CHIHI
Sequence: MINLRKTHPLMKIINNSFIDLPAPSNITSWWNFGSLLGICLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGLYYGSYMFLETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSDLVQWIWGGFSVDKATLTRFFAFHFILPFIIAALAGVHLLFLHETGSNNPIGISSDADKIPFHPYYTIKDILGMLLLILILMTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALIMSILILAIIPLLHTSKQRSLTFRPISQCLFWILVADLVTLTWIGGQPVEHPFIIIGQLASILYFFLILILMPITSLLENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ISCA1_MOUSE
Sequence: MSASLVRATVRAVSKRKLQPTRAALTLTPSAVNKIKQLLKDKPEHVGLKVGVRTRGCNGLSYSLEYTKTKGDSDEEVIQDGVRVFIEKKAQLTLLGTEMDYVEDKLSSEFVFNNPNIKGTCGCGESFHV
What is the function of this protein?
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway.  Probably involved in the binding of an intermediate of Fe/S cluster assembly.
What are the official names of this protein?
Iron-sulfur cluster assembly 1 homolog, mitochondrial, HESB-like domain-containing protein 2, Iron-sulfur assembly protein IscA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TX5_SELPU
Sequence: MLIVILTCALLVIYHAAAAEELEAKDVIESKALATLDEERFECVLKCDIQYNGKNCKGKGENKCSGGWRCRFKLCLKI
What is the function of this protein?
Probable ion channel inhibitor.  Shows insecticidal activity when injected into mealworms.
What are the official names of this protein?
Toxin OAIP 5.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 12 (Hwtx-2) family. 05 (OAIP-5) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYY_ECOLI
Sequence: MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQGYDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDSELQPSRGQARKTIASNAITINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCLICWK
What is the function of this protein?
Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (PubMed:4292198, PubMed:4579631).  Can also mischarge tRNA(Tyr) with D-tyrosine, leading to the formation of D-tyrosyl-tRNA(Tyr), which can be hydrolyzed by the D-aminoacyl-tRNA deacylase (PubMed:4292198).  In vitro, can also use the non-natural amino acid azatyrosine (PubMed:11006270).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRWN3_ARATH
Sequence: MFTPQRNRWPETDRKGKAIAFSDEIITPPPQRVLLREDDDWQKFKEVGLLDEASLERKDRDALIEKILKLEKELFDYQHNMGLLLIEKKQWTSTNNELQQAYDEAMEMLKREKTSNAITLNEADKREENLRKALIDEKQFVAELENDLKYWQREHSVVKSTSEAKLEEANALVIGMKEKALEVDRERAIAEEKFSVMNRKSSELERKLKEVETREKVHQREHLSLVTEREAHEAVFYKQREDLQEWEKKLTLEEDRLSEVKRSINHREERVMENERTIEKKEKILENLQQKISVAKSELTEKEESIKIKLNDISLKEKDFEAMKAKVDIKEKELHEFEENLIEREQMEIGKLLDDQKAVLDSRRREFEMELEQMRRSLDEELEGKKAEIEQLQVEISHKEEKLAKREAALEKKEEGVKKKEKDLDARLKTVKEKEKALKAEEKKLHMENERLLEDKECLRKLKDEIEEIGTETTKQESRIREEHESLRITKEERVEFLRLQSELKQQIDKVKQEEELLLKEREELKQDKERFEKEWEALDKKRANITREQNEVAEENEKLRNLQISEKHRLKREEMTSRDNLKRELDGVKMQKESFEADMEDLEMQKRNLDMEFQRQEEAGERDFNERARTYEKRSQEELDNINYTKKLAQREMEEMQYEKLALEREREQISVRKKLLKEQEAEMHKDITELDVLRSSLKEKRKEFICERERFLVFLEKLKSCSSCGEITENFVLSDLRLPDVEDGDKRFGKQKLKAEEALNISPSAENSKRTSLLGKIASKLLSISPIGKTDKVTDLGITVKLPESSQPDDSLDRVSGEDHEPSATEQSFTDSRIQEGPEGSLQSEMKSDKPRRGRGRGRGRGKSVRGRSQATKAVSRDSKPSDGETPRKRQREQTSRITESEQAAGDSDEGVDSITTGGRRKKRQIAVPVSQTPGQTRYQLRRHRNVGTEEDKAQASKGATEKQERVNDDIRKVPSPKETRTPPEGENRENGKAEVLVETVTHEEIVTVETETVFKVNNTGKNPVEDPQLEVGGSGEIREHGEEDDENISMIEEENEGEEEEETERQGNDASIGKKIWVFFTT
What is the function of this protein?
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (By similarity).  Required for nucleus structure organization (e. g.  size and shape) (PubMed:24308514, PubMed:23396599).
What are the official names of this protein?
Protein CROWDED NUCLEI 3, Protein LITTLE NUCLEI 3.
What is the protein family that this protein belongs to?
Belongs to the CRWN family.
What are the subcellular locations of this protein?
Nucleus membrane; Peripheral membrane protein. Nucleus, nucleoplasm. Cytoplasm. Nucleus lamina. Note=Recruited to the nucleus envelope (NE) by SUN proteins and is immobilised therein (By similarity). Punctate or bundle-like structures are detected, especially in trichomes where bundle-shape localization pattern along the long axis of the nucleus is observed. During prometaphase to anaphase, localized diffusely in the cytoplasm. Later transferred from the cytoplasm to the chromatin surface, preferentially assembling to the distal surface of the chromatin. Relocalized to the nuclear periphery during late telophase (PubMed:23396599).
Protein: PSAJ_WHEAT
Sequence: MRDIKTYLSVAPVLSTLWFGALAGLLIEINRLFPDALSFPFF
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PYRB_METAR
Sequence: MNFERKHIISTKDFSRDEIDFILDRAARLEPFARKGSTVLNGSIVATLFYEPSTRTRLSFDTAVKRLGGTTIGFDSAASSSTVKGETLADTIRIIDSYADAIVLRHPKEGAARMASEISRVPVINAGDGAGHHPTQTLLDLYTMRKECKKAICDLNVAIVGDLKYGRTVHSLAYALSLYGANLSFVSPEQLKMPGSIINYLKRKGLSITETSSLQDVLGRADVIYMTRIQKERFPDPAEYQKVAGTYRITPETLAGVGRDTIVMHPLPRVDEIAPEVDATKHARYFQQSFYGVPVRMAVLSLVMGVDI
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: GCH4_IDILO
Sequence: MPTVMPDVANQTQAQTEGALDWVGMSNIEVPLMVAAAGVPERPVAAKVEAFVNLKNPKTKGIHMSRLYLLLDKMSTEGELSHDTLKQLLNDFIESHKDISDQAFIKFDFDYHLRRKSLISKKQGWKAYPVSLTGRYDAGQLKLELSVDVPYSSTCPCSAALARQLIQDAFSEKFAGQEQVDASIMHEWLGSTEGIVATPHSQRSVAEVKVALSDSVNDFPIVELIDAIEGALKTPVQAAVKREDEQEFARLNGQNLMFCEDASRRLQHQLNQMSNFRDFWLRVNHYESLHAHDAVSVTTKGVPGGYSA
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: ISDH_STAAM
Sequence: MNKHHPKLRSFYSIRKSTLGVASVIVSTLFLITSQHQAQAAENTNTSDKISENQNNNATTTQQPKDTNQTQPATQPVITAKNYPAADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYSPVPEDHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSLVKSDTNDAVVTNDQSSSDASNQTNTNTSNQNTSTTNNANNQPQATTNMSQPAQPKSSANADQASSQPAHETNSNGNTNDKTNESSNQSDVNQQYPPADESLQDAIKNPAIIDKEHTADNWRPIDFQMKNDKGERQFYHYASTVEPATVIFTKTGPVIELGLKTASTWKKFEVYEGDKKLPVELVSYDSDKDYAYIRFPVSNGTRDVKIVSSIEYGENIHEDYDYTLMVFAQPITNNPDDYVDEETYNLQKLLAPYHKAKTLERQVYELEKLQEKLPEKYKAEYKKKLDQTRVELADQVKSAVTEFENVTPTNDQLTDLQEAHFVVFESEENSESVMDGFVEHPFYTATLNGQKYVVMKTKDDSYWKDLIVEGKRVTTVSKDPKNNSRTLIFPYIPDKAVYNAIVKVVVANIGYEGQYHVRIINQDINTKDDDTSQNNTSEPLNVQTGQEGKVADTDVAENSSTATNPKDASDKADVIEPESDVVKDADNNIDKDVQHDVDHLSDMSDNNHFDKYDLKEMDTQIAKDTDRNVDNSVGMSSNVDTDKDSNKNKDKVIQLAHIADKNNHTGKAAKLDVVKQNYNNTDKVTDKKTTEHLPSDIHKTVDKTVKTKEKAGTPSKENKLSQSKMLPKTGETTSSQSWWGLYALLGMLALFIPKFRKESK
What is the function of this protein?
Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin.  Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).
What are the official names of this protein?
Iron-regulated surface determinant protein H, Haptoglobin receptor A, Staphylococcus aureus surface protein I.
What is the protein family that this protein belongs to?
Belongs to the IsdH family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan- anchor.
Protein: TACY_STRP6
Sequence: MSNKKTFKKYSRVAGLLTVALIIGNLVTANAESNKQNTASTETTTTNEQPKPESSELTIEKAGQKMDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDKKKSEEDHTEEINDKIYSLNYNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAALQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDKATVEVNDPTYANVSTAIDNLVNQWHDNYSGGNTLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIAAYKQIFYTVSANLPNNPADVFDKSVTFKDLQRKGVSNEAPPLFVSNVAYGRTVFVKLETSSKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGGDAAEHNKVVTKDFDVIRNVIKDNATFSRKNPAYPISYTSVFLKNNKIAGVNNRTEYVETTSTEYTSGKINLSHQGAYVAQYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes.  After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Can be reversibly inactivated by oxidation.
What are the official names of this protein?
Streptolysin O, SLO, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Probably secreted as soluble protein by the accessory Sec system (By similarity). It then inserts into the host cell membrane and forms pores formed by transmembrane beta-strands (By similarity).
Protein: YB068_YEAST
Sequence: MFGSIIWSYNYTHYYFDPNAKTASANNDWIEQCGDFLKNGTVKCVVDKVYDWKDHKEAFSYMATQRAQGKLIMNVEKF
What are the official names of this protein?
Putative uncharacterized protein YBL068W-A.
Protein: MDH_RHOCS
Sequence: MARKKIALVGAGQIGGTLALLAGQKELGDIVLLDIPDAEGVAKGKALDIAEASPVEGFDAGYTGTSNYADLAGADVVIVTAGVPRKPGMSRDDLVGINARIIKAVGEGIRTHAPDAFVIVITNPLDAMVGLMQQVTGFDPAKVVGMAGVLDSARFRWFLAEEFKVSVEDVTAFVLGGHGDTMVPSVRYSTVAGIPLPDLVKMGWTTQEKLDQIVQRTRDGGAEIVGLLKTGSAFYAPAASAIAMAESYLKDKKRVMPCAARLTGQYGVDGLYIGVPVVIGAGGVEKIVEIELNAEEQAMFDKSVAAVKSLVEVTAKVAG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: CHDC_STAEQ
Sequence: MSEAAETLDGWYSLHLFYAVDWTTFRLIAEDDREAMITELETFVKDKAVARESHQGDHAIYNITGQKADLLLWFLRPEMKELNQIENEFNKLRIADYLIPTYSYVSVIELSNYLAGKSDEDPYENPHVKARLYPELPHSEYICFYPMDKRRNETYNWYMLPIEDRKTLMYNHGMIGRKYAGKIKQFITGSVGFDDYEWGVTLFSNDVLQFKKIVYEMRFDETTARYGEFGSFYIGHILNIEDFKQFFSI
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: DNLJ_ORITB
Sequence: MNKLDISTINIEQLTSDHAKKIVDFLALELQKYDQAYYSDNNPLVTDAQYDVLKNLNNKIVAKFPHLALVNDHSKKVGFTPSAQFSKVVHLKPMLSLANGFCVEDISNFITKIQNFLKIDHCPKIVCEYKIDGLSFNARYEYGVLTLASTRGDGQIGENITENLKTIQSFPQTLPITDKVFEVRGEIYITNNDFRVLNIQQQKLGKALFSNPRNAAAGSIRQLDPAITAQRPLKYFVYALGEVTNHHFASTQFELLQKLSQLKFSVNTDYILSDNLHSMIEFYNNVATERNNLAFEIDGVVYKVNDFALQERLGATSTSPRFAIAYKFPALIGRTKITNITLQVGKTGAVTPVALLIPINIAGVTISRATLHNKQEIESKDIRIGDYVFLHRAGDVIPKINGVDLSARDAQSSTRFIFPATCPSCNQNLVVNEGETVARCGNSLACPAQIYERICHFVSKDALNIDGLGRQRIRFLLDNKYIVNIVDIFLLEENNKLLSSNKLEDIAGWGIKSVNKLFKNINQAKNVILDRFIYALAVKHVGKYSAKLLAKEFKTAKNFIDQSLKLANNVTEIYEKLCNIEGLGVKTADQLKQFFMVSANVNLITKLVNILTIQDWQYHGDNLLLSNQTIVFTGTFATVSRSEIKVQAEKLGAKVGTQVSNNTDLLVVGNKAGNKLQKAQQLGIKIINEEEWIKMVNE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: Y8570_DICDI
Sequence: MFRIILERIEHSLKFSTLQEVDFGVGFKTKITERKFNRNSIGANDILFFQLSERPGQTLFFSSAVFKQSIINELNRLNNYLNRPYSIDNEPFPFSLTF
What are the official names of this protein?
Putative uncharacterized protein DDB_G0289765.
Protein: CP51_ASHGO
Sequence: MSESLLQTVVAYVELVLHHFMALSWTQQLSIVIVAPFIYSLVWQTLYSFRKDRVPLVPFMVPWVGSALAYGRAPYEFFGKCQQKYGDVFAFMLLGRVMTVYLGTKGHEFILNAKLAEVSAEEAYTKLTTPVFGEGVVYDCPNHRLMEQKKFCKNALSTEAFRRYVPMVMDEVRKYLRTSKHFMMNERSSGVVNVMETQPEMTIFTASRSLLGAEMHSMLDADFAYLYADLDKGFTPLNFVFRDLPLDNYRRRDNAQRTISSTYMKVIERRRKNNDVQDRDLIDALMTSAQYKDGVKMTDQQIANLLIGVLMGGQHTSAATSAWVLLHLAERPDIQEELYEEQMRVLDGGAKELTYELLQEMPLLNQVIKETLRMHHPLHSLFRKVTRDMPVPNTSYVIPKDHYVLASPGFCHLSEEYFPNAKEFNPHRWDNDAASSVSTGEKVDYGFGAISKGVSSPYLPFGGGRHRCIGEGFAYMQLGTIFSVVVRSMKWHFPADMKGVPNPDFTSMVTLPSEPCRIAWERRVPDQII
What is the function of this protein?
Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (By similarity).  The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity).  In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity).  Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (By similarity).  Can also use susbtrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity).
What are the official names of this protein?
Lanosterol 14-alpha demethylase, CYPLI, Cytochrome P450 51, Cytochrome P450-14DM, Cytochrome P450-LIA1, Sterol 14-alpha demethylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane.
Protein: RL2_METMJ
Sequence: MAHRIIAQNRGKGGPTYRAPSHRYKAALRHAGKNDALVSGNVIDIEHDPARHAPIALARLDSGEKIYVLATEGLGVGDTVSWGTGGTVKNGNTLPLGEIPVGAYVCNIEARPNDGGKFVRSSGVQALVIGKADDGRVGIRMPSGKNKWFNGACMATVGIVAGGGRGEKPFVKAGKKHFHVRSSSERWPRVKGVCMNVIDHPFGGGGHQHCGRPKTVARGTSPGRKVGHVAARRTGKWKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: COMB_CLOAB
Sequence: MKIDLIISADDIKEEKVKNKTAVVIDMLRATSVITTALNNGCKRVVPVLTVEEALKKVKEYGKDAILGGERKGLKIEGFDFSNSPMEYTEDVVKGKTLIMTTTNGTRAIKGSETARDILIGSVLNGEAVAEKIVELNNDVVIVNAGTYGEFSIDDFICSGYIINCVMDRMKKLELTDAATTAQYVYKTNEDIKGFVKYAKHYKRIMELGLKKDFEYCCKKDIVKLVPQYTNGEIL
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.
Protein: RL3_KINRD
Sequence: MSDRQVRGVLGTKLGMTQLWDADNRIVPVTVVKVEPNVVTQIRTTTVDGYEAVQLATTAIAQRKATKPAAGHFEKAGVAPRRHLVELRTTDAADYSLGQEVTAEAFATGATVDVVGTTKGKGFAGVMKRHGFHGVGASHGAHRNHRKPGSIGGCATPGRVFKGMRMAGRMGAARQTTQNLTVQAVDAEKGLLLITGAIPGPRGGLVLVKSASKARVKEA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: YJ84_YEAST
Sequence: MGTDFSASHCANCSAVGFILEPACEPCKRSTLDWPGGASEVSGRYSFAENSSLSSLIASSHSSTPFSADGSLAGVRTDDWKRATHVPLCHRRRGLTNIYLLAQCSIIFTSDPYLSIFLLKTIAAVFSVRV
What are the official names of this protein?
Putative uncharacterized protein YJR114W.
Protein: CRCB2_SYNS9
Sequence: MAEQQQQRSLSAELQELVLVALGAVPGALLRWQVALHWADRHLLVNVLGAALLGLLAGLPAAPRRQLLVGIGFCGSLTTFSSWMVDAMQLISAGQIAEAFGLIGLTLGLGVGAAALGFWLGQRLRLLKLPRSEP
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VPS28_DROME
Sequence: MQEQSPELYEEVKLFRNAREREKYDNMADLYAIINTIQQLEKAYIRDCITPQEYTAACSKYLVQYKVAFKQVQCDEFPSVETFVKKFRLDCPAALERIREDRPITIRDDKGNTSKCIAEIVSLFITIMDKLRLQINTMDALQPDVKDLADNMNRLSLIPEDFDAKLKVEKWLGSLNEMQASDELSEGQVRQFLFDLESAYADFNKLLHSQ
What is the function of this protein?
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 28 homolog, ESCRT-I complex subunit VPS28.
What is the protein family that this protein belongs to?
Belongs to the VPS28 family.
What are the subcellular locations of this protein?
Endosome.