PharMolix/UniProtQA huggingface dataset:
Protein: PURT_BACVZ
Sequence: MYQAKKMLLLGSGELGKEVVIEAQRLGVVTVAVDSYEHAPAMQAAHKSYVIDMLDKAQVREVIEKEKPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKLTMDREGIRRLAAETLHLPTAGYEFANTYEEFKEAAETIGFPCVVKPLMSSSGKGQSVCRSASGLKSCWDMAMEGGRVKNGRVIVEEFIPFESEITLLTVRAANGTSFCAPIGHEQKDGDYIESWQPHHMTEQQIKEAKHIAKSITDELGGYGLFGVELFLTEDKVYFSEVSPRPHDTGLVTLVTQNLSEFALHVRAVLGFPIPEITQLSPGASRPLKAPKELADYAVEGLEKALAVKSTQVRVFGKPVTKVGRRMAVALSAAETVEEARERAAEALSHLSIT
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: MTEF6_ARATH
Sequence: MEVTNTSSIMWFFRDKGFDDPSIDKMLRKCKQLEKAQSDVASENWDYLSNIVGIQERKLPYIVSRCPKILTLRLDERLIPMVECLSSLGRNPREVASAITKFPPILSHSVEEKLCPLLAFFQALGVPETQLGKMILFNPRLISYSIDTKLTVIVSFLASLGLDQDGMIGKVLVKNPFLMGYSVDKRLRPTTEFLKSSVGLSEDGIKSVVMNFPQLLCRDVNKILKPNYDYLKECGFGDSQIATMVTGYPQILIKSVKNSLQPRIRFLVQVMGRGMDEVASYPEFFHHGLKKKVESRFKLVKKNNIDCSLREMLDCNTKKFHEKFGFSEVTASF
What is the function of this protein?
Transcription termination factor essential for chloroplast development.  Required for maturation of 16S rRNA, 18S rRNA and 23S rRNA in the chloroplast.  Binds to a specific region within the tRNA(Ile)(GAU) gene at a position adjacent to and downstream of the 16S rRNA gene.  Required for the maturation of tRNA(Ile)(GAU).  Binds to double-stranded DNA.
What are the official names of this protein?
Transcription termination factor MTERF6, chloroplastic/mitochondrial, Mitochondrial transcription termination factor 6, Protein PIGMENT DEFECTIVE 191.
What is the protein family that this protein belongs to?
Belongs to the mTERF family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Mitochondrion.
Protein: CAPS_CAEBR
Sequence: MLGASSSEEEDDDFQDDHESQLPIAQVKKRSLLSGAMTPRSSSPAPSDSVSQTNSLKRNNSSSQARRKDSVHSQTPARSPMKMNSPSPMPQARTMSNVTRPVLQNSQELDGEEIEETEGSGTMVASDDGGPSLSKEEQERIKAEKEEEEHKKNLQMYVFIARCVAYPFNGQQTGDMARRQMKVNKPELARIRERFAQFLRGETNIAADEAFTKAIQSYTEVFLKSERVQKVVHAGGFSQHDFREVFRLIIEKRVRSLPDIEGLSKDTVLNSWLAKFDAIIKGDETDQNRNARGRSRNPNSAMSADAVLGKEQLYDVFQQILGVKKFEHQIIFNSLQLDNPDEQAAAIRREFATREEALKDPMKMKRLTPKFVVKDMETLYMDEVRMSINTLIGNLETVPVTTRGQTVGKRKDKSRSRSIEDLSLFNSLKRRTSSGSLNKGDSDDGDVTLTKSDVSLALSMEVVVMEVQGLKSIQPNKIVYCVMDVDGHKLATDHAEASKPKWDTQGDFTTKTPLPTVKVKLYTEVKSLVSFDDKELGKIMITPTPNCSRNPEWYTMTLPKNSQDSSLKIRIAIRIEKPPNLKYSGHCWCIGRNSWKKWKKRFFCLVQVSQYAFAVCSFREKKADPTEFIQLDGFTIDYMPESDPELSAQGGKHFFTAIKEGDELKFATDDENERHLWVQALYRATGQAYKPVPPKQSTIAPKAQGFQDKASKHGMDALIQADSINFDHDHLYSDIQRLTLDFRINEPICSLGWFSPGQAFVLEEYSARYMVRGCFRHVTLLSNLLDKADDGLLIDPALIHYSFAFCASHVHGNRCMPDRQGPEGVGTVTLEEKEKFQEIKERLRVLLEKQITNFRYCFPFGRPEGALKGTLGLLERVLMKDVVSPVPPEEVRAVIRKCLEDAALVNYTRICNEAKIEQRMGNDVSPAQRIEDMIRVTEFCIDLLKENEEHHGEAFSWFSDLLSDHSEIFWSLYSVDLDSALEVQPHDSWDSFPLFQMLNDFLLSEPNLKGGIFHNKLVQQFQPLVVRYIDLMEHSIAQAIDKGFLKEKWESRKEGCATSEDIYWKMDALHTFVIDLNWPEEDFRKYLQTKMKTLTSDLISKVSDCTFTAFDSWMQKAKKSTDYMLPSEVCVQINVMFSSKSRAVRVTVDSGEYKYQSKLDETLETMLKTMESCIQEKLLGVLESVLSRLARYDEGNPIGAILNIAPKPASIFNKLKTMAGDTSVQSSSSTRQPLTAQQSSGQIGNSYVTFFHGCTELLRQVIIDEIWVNGLFEHWYDNQMKAINDWLTERLQQSLSATQFISLSNIVKKVYQDFAMQGIDEERLNSKTYQSISRRLQLEESNSHIQEGIRRLKT
What is the function of this protein?
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides.  Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles.  May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles.  Specifically required to activate the neuronal G-alpha pathway.  Functions with G-alpha proteins from the same motor neurons to regulate locomotion.  Involved in regulating entry into quiescence triggered by satiety.  Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt.  Plays a role in octopamine signaling and specifically, the octopamine inhibition of aversion responses in olfactory sensory neurons.  Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior.
What are the official names of this protein?
Calcium-dependent secretion activator, Uncoordinated protein 31.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane. Synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions.
Protein: FACR1_HUMAN
Sequence: MVSIPEYYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVLSGKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEVIIDSTNIIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTIRASNNALADLVPVDVVVNMSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVEYHVISTFKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTITRLHKAMVFLEYFTSNSWVWNTENVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCLGTKKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSYFRASSTMRY
What is the function of this protein?
Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123).  It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123, PubMed:33239752).  In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity).
What are the official names of this protein?
Fatty acyl-CoA reductase 1, Male sterility domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the fatty acyl-CoA reductase family.
Protein: HORM1_DANRE
Sequence: MTCEQKSRPVQSCQMLPDVVSNEQQSLVLVKKLLAIAISSITYLRGLFSEKAYGRKYVGELKVYILREDSCPGAQQIVHWLQGCFDALQRRYLRMVLLSIYCDPDNPQKVTECYQFKIKYTEKGPQMDFESKNGQSLTKMACDNTQKSSMLLVRKLYMLMQNLGPLPDDVCLNMKLLYYDEVTPQEYQPPGFKEDDNGTLMFEREPVNLTMGEVVTPFHSIKMNVTTEKKRIEPFEDDVEVCVSTKWSLKISEDGMMSETSVQQECMTKENVITDAGIEYSETQETQEQPHRHTKEDFSTNPKMDNLVKKTADLKVDARKTRSGRIFEPQISQLEFPLSQDPQPSVPKRRKVSVPK
What is the function of this protein?
Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal-complex formation independently and playing key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint.
What are the official names of this protein?
HORMA domain-containing protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis.
Protein: ILF3_RAT
Sequence: MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSTFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAPPPVVEAVSNPSSVFPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNAGAGYGSYGYSSNSATAGYSQFYSNGGHYGNAGGGGSGGGGGSSSYSSYYQGDSYNSPVPPKHAGKKPLHGGQQKPSYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSYSSYSNSYNSPGGGGGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSYNTGSHGGYGAGSGGSSSYQGKQGGYSSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR
What is the function of this protein?
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs.  Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons.  Plays thereby a role in the back-splicing of a subset of circRNAs.  As a consequence, participates in a wide range of transcriptional and post-transcriptional processes.  Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity).  Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response.  Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs.  In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs.
What are the official names of this protein?
Interleukin enhancer-binding factor 3.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: NGFV3_NOTSC
Sequence: MSMLCYTLIIAFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKAEDQELGSVANIIVDPKLFQKRRFQSSRVLFSTQPPPLSRDEQSVEFLDNEDTLNRNIRAKRENHPVHNQGEHSVCDSVSDWVIKTTATDIRGNMVTVMVDINRDNEVYKQYFFETKCRNPNPNPVQSECRGIDSRLWNSYCTTTRTFVRALTMEGNQASWRFIRIDTACVCVIIRKTDNF
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Venom nerve growth factor 3, v-NGF-3, vNGF-3.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMH_SHEDO
Sequence: MKLQLIAVGTKMPDWVTRGFEEYQRRFPRDMALELIEIPAGKRGKNADIARILQKEGDLMLAAVAKGNHIVSLDLPGKNWTTPELAEQLSKWQLDGRDVSLLIGGPEGLSPACKEAASQSWCLSALTLPHPLVRVLVAESLYRAWSINNNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNR4_RAT
Sequence: MYVWVQQPTAFLLLGLSLGVTVKLNCVKDTYPSGHKCCRECQPGHGMVSRCDHTRDTVCHPCEPGFYNEAVNYDTCKQCTQCNHRSGSELKQNCTPTEDTVCQCRPGTQPRQDSSHKLGVDCVPCPPGHFSPGSNQACKPWTNCTLSGKQIRHPASNSLDTVCEDRSLLATLLWETQRTTFRPTTVPSTTVWPRTSQLPSTPTLVAPEGPAFAVILGLGLGLLAPLTVLLALYLLRKAWRSPNTPKPCWGNSFRTPIQEEQTDTHFTLAKI
What is the function of this protein?
Receptor for TNFSF4/OX40L/GP34.  Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 4, MRC OX40, OX40 antigen, OX40L receptor.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ACCC_ECO57
Sequence: MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNSIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLGLQEK
What is the function of this protein?
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
What are the official names of this protein?
Biotin carboxylase, Acetyl-coenzyme A carboxylase biotin carboxylase subunit A.
Protein: MRS3_YEAST
Sequence: MVENSSSNNSTRPIPAIPMDLPDYEALPTHAPLYHQLIAGAFAGIMEHSVMFPIDALKTRIQSANAKSLSAKNMLSQISHISTSEGTLALWKGVQSVILGAGPAHAVYFGTYEFCKKNLIDSSDTQTHHPFKTAISGACATTASDALMNPFDTIKQRIQLNTSASVWQTTKQIYQSEGLAAFYYSYPTTLVMNIPFAAFNFVIYESSTKFLNPSNEYNPLIHCLCGSISGSTCAAITTPLDCIKTVLQIRGSQTVSLEIMRKADTFSKAASAIYQVYGWKGFWRGWKPRIVANMPATAISWTAYECAKHFLMTY
What is the function of this protein?
MRS3 suppresses a mitochondrial splice defect in the first intron of the COB gene.  It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations).
What are the official names of this protein?
Mitochondrial RNA-splicing protein MRS3.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: INS2_THUOR
Sequence: VAPPQHLCGSHLVDALYLVCGDRGFFYNPKGIVEQCCHKPCNIFDLQNYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity).
What are the official names of this protein?
Insulin-2.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBD_CYAPA
Sequence: MTVAIGRSDSERGWFDVLDDWLKRDRFVFLGWSGLLLLPCAYLAVGAWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSMGHSILFVWGPEAQGDFTRWCQIGGLWTFTALHGALGLIGFTLRQFEIARLIGLRPYNAIAFSGPIAVFVSVFLLYPLGQAGWFFAPSFGVAAIFRFLLFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGSNTFPAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSAIGVVGLGVNLRAYDFVSQEIRAAEDPEFETFYTKNLLLNEGIRAWMAVQDQPHENFVFSEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, cyanelle thylakoid membrane; Multi-pass membrane protein.
Protein: RR8_MARPO
Sequence: MGNDTIANMITSIRNANLGKIKTVQVPATNITRNIAKILFQEGFIDNFIDNKQNTKDILILNLKYQGKKKKSYITTLRRISKPGLRIYSNHKEIPKVLGGMGIVILSTSRGIMTDREARQKKIGGELLCYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: THCL1_AMISM
Sequence: SCNCVCGVCCSCSP
What is the function of this protein?
Has bacteriocidal activity against Gram-positive bacteria including multi-drug resistant strains such as S. aureus MS9610 and methicillin-resistant S. aureus, but is not active against most Gram-negative bacteria and fungi.
What are the official names of this protein?
Amythiamicin A/B.
What is the protein family that this protein belongs to?
Belongs to the thiocillin family.
What are the subcellular locations of this protein?
Secreted.
Protein: OE56_NPVHZ
Sequence: ALRRTGGSYYHIGLNGGEQVESCLLRYRTCVLDVNNLNDVNVCPSDPLIDNINALQSVCHGYNAEVERTVCRRSDPNADPLSLQYVDISPLATGHTISCIEPYDFGDLIGDLGLDGLLGEEGLLNKSSDKSSTSFQKLLPIIVVLGIVLLIIFIGYIVIKRMLMQPPPPPANYNR
What is the function of this protein?
Structural protein that is specific for occlusion-derived virus (ODV) envelopes but not of budded virus (BV).
What are the official names of this protein?
Occlusion-derived virus envelope protein E56, ODV-E56, ODVP-6E.
What is the protein family that this protein belongs to?
Belongs to the baculoviridae E56 family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Note=Localized to the envelope region of preoccluded bundles of virions.
Protein: LEUD_CLOAB
Sequence: MKVNGDVLKYGDNIDTDVIIPARYLNTSVPEELAKHCMEDLDVDFLKKLKTGDIVVGGRNFGCGSSREHAPICIKAAGVSCVIAKSFARIFYRNSINIGFPILECEEAVNDASTGDKLEVDFIEGIIKNVTLNKEYKAQPFPDFMLKIMKNEGLTNCVKKGLF
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: RASP3_TOXGG
Sequence: MENRPRQQTSGHDCSLGTGDDLSSRPGRVDLLRAHISPTTVKQVSVNHERKVVGSSSSRSAVWGISPDGSNAFESKNFGLEGDSNHTVEHEVIKEEDSQKKSPFSCGSAPRVVDSPGASVVSREGRVGPPSDGSAVVSGDDETDANNSEDGTEDEIVSEEGRRTEDEGDVTSRSDQVPCTPPPMWVPEVLSDESEETPLRRVGEERHVSDSSSGGDGYLRGTRQGRVRPHAVPPLFHTPSHFTPVRATSSRLISLSSDSERMHRMAQKVQTQPEMKPKELDKEAERKQEQLRSSKGDNKGIFKGLLRQLTRGYTGVAHLFDGLASDFKPHTENEGSSSNDVLTEERTVQPSSAVVSDKRVTGNGTGVERFKPRVRHRLSQECRPSFPEKPDEETSLSTTLPTKLKSLFSFASSHWNHASPGEGEATEAAGASVSGSSSFLAANANHSPSMLDAYGRPPQKRTQRRSFFGSVAAAASNAFAEAGAVAAAAAEAVAAVGQSSSDSSGDSSSESDHSGRERSRAFRGKRGGSNEITTMRSQRSAGHLSFSREPERESDQGEMTPTGETSGSESELDQVILTEHATPFNFVLWATREAAASLQRPLLSGPPEEEAGNAEELRSTENAIHRRELQRLGRLRAVALRLLLLICEDDSWCQDGTTRQSAHKGANDGARRRFPPIVQGVRGRRRSDRDTESPPTEATQDSEEVDRLWSQWINGSPETEGGEDADRKQEEKRLQGRGVSRSRYMWKAANRMLSVDRRLRKLHSDTAVRRMGETEFWKLYFYQVFLLMNRFDRQAHKVLRSLSCSFTLTTGEGGDENQPQEVAHDVLSQTSGFTESDTSSPSPSYGFASSPCTSARLIIPPTGLPDNTEEGEPLSFGGVSLEPKDEEAPEQVRQDGLGALAYAIFSSSRSPSLSSSSSGTTSVSARGTGSSFSRDVGESPLLVPRDSHRSGVGSETYSAGGDSPALREKVISENAGCLPLGRAPSQPTNTVSSVSSNRAYLEPASRRGSFSVVPVSGRRLRDALFAKRVSSSSQVNGRVSTSRGTMGEDRHQDQQGDNRLEGPSHLSAHNSLYQLGSRSGNCVQIKVKELKELDGTCGDTHQPGLACKGKEVQGARA
What are the official names of this protein?
Rhoptry apical surface protein 3, TgRASP3.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, rhoptry membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the extremity of the neck of the rhoptry.
Protein: IL1A_LAMGL
Sequence: MAKVPDLFEDLKNCYSENEEYGSEIDHLSLNQKSFYDASHEPLHEDCMDKLMSLSTSETSKTSKLTFKESVVMVASNGKILKKRRLSLNQFITDDDLEAIANDTEEEIIKPRSVPYNLQSNVKYNYMRIVNHQCILNDALNRSIIRDPSGQYLMAAVLNNLDNAVKFDMGAYTSEEDSQLPVTLRISKTQLFVSAQNEDEPVLLKEMPETPKIIKDETNLLFFWEKHGSMDYFKSVAHPKLFIATKQEKLVHMASGPPSITDFQILEK
What is the function of this protein?
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems.  After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex.  Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.  In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways.  Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.  In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
What are the official names of this protein?
Interleukin-1 alpha, IL-1 alpha.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Recruited to DNA damage sites and secreted after genotoxic stress.
Protein: PDXH_PORGI
Sequence: MDLHFENIRREYDKRSLSASDLTPTPFDLVTRWLQDAVEAKTYEPTAVIVGTATPDGHPSTRTVLLKEFMNNEFIFYSNYESRKGQQMAANPHVCLTFLWHELERQIHVEGDVRILEPELSDAYFATRPYKSRVGARISPQSRPIPGRSFIVQEFMKESLKYAGRTVPRPDTWGGFAVKPVRIEFWQGRESRLHDRFLYELRPDASWSVHRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: YCF4_NANDO
Sequence: MNWRSERIWIELITGSRKTSNFFWACILFLGSLGFLLVGTSSYLGRNLISLFPSQQILFFPQGIVMSFYGIAGLFISSYLWCTIWWNVGSGYDQFDRKEGIVCIFRWGFPGRNRRIFLRFLMRDIQSIRIEVKEGLYPRRVLYMEIRGQGALPLTRIDENLTPREIEQKAAELAYFLRVPIEVF
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.