PharMolix/UniProtQA huggingface dataset:
Protein: HTXH_STUST
Sequence: MGYVAIKGGGRAIAGAEAAVEALRCAEGPAGTPLTLSAIEQQLRLLTSRVVSEGGLYHPRLAALAIKQMQGDTLEAAFALRAYRSTKPRLMDVPVQDTSRMRLIRRISSAFKDIPGGQMLGPTTDYALRLMRLDLANESPEDFRAVSRRFLDSVADTDLPDSFPKVVDALRDEGLLPPLTRRAHAAFDITRDPLVFPVPRSAALATMARAETGSLLAIAYSNMRGYGDVHPTIAELRVGYVPVMLPHPVTGEPIEAGEVLMTECEVVAMFEGDATDGPPTFTLGYGACFGHNEVKAIAMAILDRALQKGMRDGPSNPSEDPEFVLLHVDGVDSMGFASHYKMPHYVTFQSDMDRLRTTQDKATAQPTQEGAPS
What is the function of this protein?
Belongs to an operon involved in hypophosphite oxidation.  Exact function not known.
What are the official names of this protein?
Putative C-P lyase subunit protein HtxH.
What is the protein family that this protein belongs to?
Belongs to the PhnI family.
Protein: Y3092_BACC7
Sequence: MKIYVDADACPVKDVIIFEATKAEIPVTLVTSFSHYSNAEQPKGVETIYVDSGADAADYRIMQLAQKEDLIITQDYGLASLALAKGCIVLHHKGYKYTNDNIEQLLQTRYLSAMVRKSGKRTKGPKPFTAEDKEKFRALFKSFIAR
What are the official names of this protein?
UPF0178 protein BCAH187_A3092.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: ZAPB_SHIDS
Sequence: MTMSLEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNSLSQEVQNAQHQREELERENNHLKEQQNGWQERLQALLGRMEEV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: UBIB_XANOR
Sequence: MKAILRASRIGRVILRYRLDALLEGTPAERWLRLAKPFVPRASAEIAVQSRGARLRLALQELGPIFVKFGQILSTRRDLIPADVAEELTLLQDRVKPFDGEAARLIVERALGLPVSVAFASFDTVPLASASIAQVHAATLPPDANGVRREVVVKVLRPEIERQIDADIALLHSLATLVERTHPRADKIRPREVVAEIEGTLSAELDLQREGANASVLRRFWEGSDDLYVPEVIWSHTAERALTLERVYGIPSDDIAKLDAAGIDRKALAAKGVRVFYTQVFRDNFFHADAHAGNIWVDSDPERRLNPRFIALDFGIMGQLSQEDQYYLAENFMAIFHKDYRRMAELHVEAGWMPSNVRIDELEAAARSVCEPYFTRPLSEISLAQVLIKLFRVAQRYELTLQPQLILLQKTLLNIEGVGRQLDPKLDIWAVARPVLERILRERYSPRRVLRELSKRLPEIMTHAPDMPRLVHSWLKQQVEGRHQIDIRSTELLALDLSLRKLQTRVVTAITGSGLLVVAAVLYGLHPDGWYLGTVPVWSWISGGAGSAALLVAWLRR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS14Z_MESM1
Sequence: MAKTSLKVKATRHPKYSARAYTRCQICGRPQAVLRKYKICRICFRKLAHEGKIPGMKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: RK14_IPOPU
Sequence: MIQPQTHLNVADNSGARELMCIRIIGASNRRYAHIGDIIVAVIKEAVPNMPLERSEVVRAVIVRTCKELKRDNGMIIRYDDNAAVVIDKEGNPKGTRIFGAIARELRQFNFTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SUT2_STYHA
Sequence: MSQRVSDQAMAEVIAETRTNSSSRRHGGGDDTPSLPYMHKVGAPPKQTLFQEIKHSFNETFFPDKPFGNFKDQSGSRKFVLGLQYIFPILEWGRHYDLKKFRGDFIAGLTIASLCIPQDLAYAKLANLDPWYGLYSSFVAPLVYAFMGTSRDIAIGPVAVVSLLLGTLLSNEISNTKSHDYLRLAFTATFFAGVTQMLLGVCRLGFLIDFLSHAAIVGFMAGAAITIGLQQLKGLLGIKDFTKNSDIVSVMHSVWSNVHHGWNWETILIGLSFLIFLLITKYIAKKNKKLFWVSAISPMICVIVSTFFVYITRADKRGVTIVKHIKSGVNPSSANEIFFHGKYLGAGVRVGVVAGLVALTEAMAIGRTFAAMKDYSIDGNKEMVAMGTMNIVGSLTSCYVTTGSFSRSAVNYMAGCKTAVSNIVMAIVVLLTLLVITPLFKYTPNAVLASIIIAAVVNLVNIEAMVLLWKIDKFDFVACMGAFFGVIFKSVEIGLLIAVAISFAKILLQVTRPRTAVLGKLPGTSVYRNIQQYPKAEQIPGMLIIRVDSAIYFSNSNYIKERILRWLIDEGAQRTESELPEIQHLIVEMSPVTDIDTSGIHAFEELYKTLQKREVQLMLANPGPVVIEKLHASNLAELIGEDKIFLTVADAVATYGPKTAAF
What is the function of this protein?
High-affinity H(+)/sulfate cotransporter that mediates the uptake of sulfate by plant roots from low concentrations of sulfate in the soil solution.
What are the official names of this protein?
High affinity sulfate transporter 2.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TEDC1_HUMAN
Sequence: MGRRRQRVDPAAGARAGALPEAIAALSRSLPSGPSPEIFRRAKFDRPEATSALWQLLFRVLSPLPAGNALASLALEVQARLVKSALCSQGYPRLALAQLPEDGSQGSRELLLALSWLLARGPVPEQMLAQARVPLGDEMTVCQCEALASPGPPAPHMEAEGPVDVRHVQWLMGKLRFRWRQLVSSQQEQCALLSKIHLYTRGCHSDQSLSHLSVTEAEMLRDPEGGQQVSGAGAAQNLDLAYPKCLHSFCTPGMGPRTFWNDLWLVCEQPGLLPGDWAAPLDPGGASACSLLSPFRALLRTLERENQRLEAVLAWRRSELVFWRWMDTVLGTCAPEVPAAASQPTFLPWVPERGGGELDLVVRELQALEEELREAAERRRAAWEAKAGGCGRGPEWSAARRASREAVEKELGALQQCWERDGGPAQPHGPHRLVRREDGAAGDRDLRAAVVIRTLRSQEACLEAVLRRLQGQCRQELARLVGARPGLIWIPPPGR
What is the function of this protein?
Acts as a positive regulator of ciliary hedgehog signaling.  Required for centriole stability (By similarity).  May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (PubMed:28796488).
What are the official names of this protein?
Tubulin epsilon and delta complex protein 1.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: OBGC2_ORYSJ
Sequence: MPLLLHPRFPSSHAAACAHRAAAAHRDARPALRLPELHATRRRRNNVACRATRAREAPPQQQNTAAALSKEAHKYFDHAVVTVRAGDGGHGAVLAMPASPSTDAPKSPRRRSDKGKRSGVKKVSYKRNYDGSVALPMGGHGGDVVVYADEAEETLLRFHEKARYCAKRGGNVGATGTLSSRMHNGFAGETLRIPVPVGTVVKRKKGAVLADLAHPGDEVIVARGGQGGISLIDVPEYRRRKAMVLSPNIMRDVSDRVLIHGQPGEEVSLELILRVVADVGLVGLPNAGKSTLLSAITLARPDIADYPFTTLMPNLGRLGGDPALGALQFSSEATLADLPGLIEGAHLGKGLGRNFLRHLRRTRVIVHVVDAAADDPVDDYKIVREELRMYNPQYLERPYVVVLNKIDLPKAQDRLSSLAFEISSIGCEECDGNNTSEDSLNGNTGEHNTSSETKVEGGEKELRDYPRPQAVVGASVLKHIGIDEMLKEIRAALRKCFDHRLPEP
What is the function of this protein?
May bind GTP and have GTPase activity.
What are the official names of this protein?
Probable GTP-binding protein OBGC2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Protein: NUOH_RICPR
Sequence: MIEYFCEYMFPLTVIALKVVAITIPLILCVAYLTYAERRVIGLMQLRRGPNVVGPFGLLQPIADAVKLLFKEPIIPTDADKILFILAPIITFVLSLIGWAVIPFSSGVVLADINVGVLYILAISSLSVYGIIIAGWASNSKYAFLGAIRSSAQMISYEVSMGLVIITVLLTTGTLNLSGIIEAQKTLPWWIDLMLLPMSIVFFISVLAETNRLPFDLPEAESELVAGYNVEYSSMGFALFFLGEYANMILVSAMTTTLFLGGYLPPFNLSFLDCIPGFFWFVFKVGFLLFCFLWIRATLPRYRYDQLMRLGWKVFLPFTLFGVVLVSSVLFYTDNLPSV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL13_BUCCC
Sequence: MKSFSAKITSIKKNWYCIDATNKILGRLASQVSIFLRGKNKPEFTPHIDVGDYIIIINASKIVVTGNKEKNKFYYHHSGYVGGIKKYTFKYMMLHHPTRIIKKAIKGMLPKGSLGQKIFKKLKVFPFNQHNLISQKPVFLNI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RECO_BACMK
Sequence: MFQKVEGIVIRTTDYGETNKIVTIYSREFGKVSAMARGAKKPKSRLAAISQLMTHGHFLIQMGSGLGTLQQGEIISSMKEIREDIFLTAYASFIIELTDKATEDKKHNPYLFEMLYQTLHYMCEGVDPEVLSLIYQTKMLPVLGMRPYFDTCAICHQETDFVAFSVREGGFLCSRHAEQDPYRIPVGEAVHKLLRLFFHFDLHRLGNVSVKDSTKKQMRTVLNTYYDEYCGIYLKTRRFLEQLDKFQI
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: PSAC_GOSBA
Sequence: MSHSVKIYDTCIGCTQCVRACPTDVLEMIPWDGCKAKQIASAPRTEDCVGCKRCESACPTDFLSVRVYLWHETTRSMGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: KAD_HAEIE
Sequence: MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMFRAAIKAGTELGKQAKALMDEGKLVPDELTVALVKDRIAQADCANGFLLDGFPRTIPQADALKDSGVKIDFVLEFDVPDEVIVERMSGRRVHQTSGRSYHIVYNPPKVEGKDDVTGEDLIIRADDKPETVLDRLAVYHKQTSPLIDYYQAEAKAGNTQYFRLDGTQKVEEVSQELDKILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOB2_HUMAN
Sequence: MDWLMGKSKAKPNGKKPAAEERKAYLEPEHTKARITDFQFKELVVLPREIDLNEWLASNTTTFFHHINLQYSTISEFCTGETCQTMAVCNTQYYWYDERGKKVKCTAPQYVDFVMSSVQKLVTDEDVFPTKYGREFPSSFESLVRKICRHLFHVLAHIYWAHFKETLALELHGHLNTLYVHFILFAREFNLLDPKETAIMDDLTEVLCSGAGGVHSGGSGDGAGSGGPGAQNHVKER
What is the function of this protein?
Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.
What are the official names of this protein?
MOB kinase activator 2, HCCA2, Mob2 homolog, Mps one binder kinase activator-like 2.
What is the protein family that this protein belongs to?
Belongs to the MOB1/phocein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region.
Protein: SECA_CHESB
Sequence: MVSLGGLARKIFGSSNERRVRALQPRAEQIGALEKEMQALSDEALRGKTDEFRKKLADGADLDDLLVPAFAVVREAARRVLGLRPFDVQLIGGMVLHQGAIAEMKTGEGKTLVATLPVYLNALTGKGVHVVTVNDYLARRDAEWMGRVYGFLGLTTGVIVHGLSDEERRAAYACDVTYATNNELGFDYLRDNMKYERAQMVQRGHAYAIVDEVDSILVDEARTPLIISGPLDDRSELYNTIDTFILKLEPADYEVDEKQRTATFTEEGTEKVENLLREANLFKGDSLYDVENVAIVHHLNNALKAHRLFQRDKDYIVRNDEVIIIDEFTGRMMPGRRYSDGLHQALEAKEHVKIQPENQTLASITFQNYFRMYGKLAGMTGTASTEAEEFGNIYGLDVVEIPTNLPVSRIDEDDEVYRTVEEKYRAIVREIKEAREKGQPILVGTTSIEKSEYLAERLRKDGLKDFEILNARHHEREAYIVSQAGKPGAITIATNMAGRGTDIQLGGNADMRIHQELGDMPAGPERDAKEKAIREDVQRLKEKALAAGGLYVLATERHESRRIDNQLRGRSGRQGDPGRSKFFLSLQDDLMRIFGSDRMDGMLQKLGLKEDEAIVHPWINKALEKAQKKVEARNFDIRKNLLKYDDVMNDQRKVVFEQRIELMDGENLSETVAEMRQDVIDDLVERHIPANAYAEQWDAKGLKEGVLQYLNLDLPIDEWVKEEGIAEDDIRERITEAANKAAAERAERFGPDIMTYVEKSIVLQTLDHLWREHLVNLDHLRSVIGFRGYAQRDPLNEYKSEAFELFQAMLGNLRQAVTAQLMRVELVREAAEAPPPPAPPAMQAHHLDATTGEDEFANGDTMTLARADARIVPAEQRDPNDPSTWGKVGRNEACPCGSGKKYKHCHGTFA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: BMBP_LISIN
Sequence: MNIYRYEENPLITPLDVKPIHEGFEVIGAFNGGVAEYNGEVLLLLRVAEKPVSEDPEIVLAPVYNAKNKELELQSFRLDDENYDFEDPRMIRSKAKLEGFSYLTSLSYIRIARSKDGHHFTLDEKPFLYPFNEYQTFGIEDARVTQIGDTYHVNFSAVSEFGVADALVTTKDFENLEYQGNIFAPENKDVLIFPEKINGKYYALHRPSLKSIGNLDIWIASSPDLRSFGDHRHLLGIRPGEYDSGRVGGGCVPIKTEEGWLILYHGATEENRYVMGAALLDLNDPTIVLKRTKTPILEPVADYEKNGFFGDVVFACGAIQEGDTLHMYYGVADTSMAGCDMKISEILHQLEVEAK
What is the function of this protein?
Catalyzes the reversible phosphorolysis of 1,2-beta-oligomannan (PubMed:26632508).  In phosphorolytic reactions, prefers beta-1,2-mannobiose (beta-1,2-Man2) as substrate, but can also use beta-1,2-mannotriose (PubMed:26632508).
What are the official names of this protein?
Beta-1,2-mannobiose phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 130 family.
Protein: SYP_ALKEH
Sequence: MRASLFPLSTSKETPADAEIVSHQLMLRAGMIRKLAAGLYTWTPLGLRVLRKVEQIVREEMDRAGAHELLMPAVQPAELWQESTRWDKYGPELLRLKDRHERDFCFGPTHEEVITDYVRREVKSYRQLPLNLYQIQTKFRDEIRPRFGVMRAREFLMKDAYSFHLDDDCLARTYQVMYETYTRIFERTGLVFRAVAADSGNIGGSVSHEFHVLAESGEDAVAFSDESDYAANVELAEAVAPAGEAPPPAETMRRVDTPGARTIDDLVRDYGLPIEKTVKTLVVHGADGGLVALLVRGDHSLNDVKATTLPQVAEPLVMAGEEEIRAAVGAGPGSLGPVELPLPCVVDRSVAVMSDFAAGANQDDAHYFGINWGRDVALPEVADLREVVAGDPSPDGRGTLEIARGIEVGHIFQLGREYSEKMKATVLNEAGDAQTVTMGCYGIGVSRVVAAAIEQNHDDNGIIWPAPIAPFQLALVPIGMNRSEAVTEQAEKLYAELQAEGVEVFFDDRDARPGVKFADMELIGIPHRLVIGDRGLKNGVVEYRGRRDSESTDVPLAELSAFLRERLG
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_LISW6
Sequence: MLQPHLVIGSAFTFGDAFFTLFAFAILLVLIRIYAWKPLMGVMKEREEHIGSEIDAAEESRAQAEQLLAEQKSVLQQARVESQTMIENAKQLGEKEREEIVKTARRESERIKEEAKTDIAREKEDAISALREQVGSLSVLIASKVIEKNLDEKEQSNLIQDYIERLGDDK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: NUOK_HELPB
Sequence: MIGLNHYLIVSGLLFCIGLAGMLKRKNILLLFFSTEIMLNAINIGFVAISRYTHNLDGQMFALFIIAIAASEVAIGLGLVILWFKKYKSLDIDSLNAMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UHRF1_XENLA
Sequence: MWIQVRTMDGRDTRRIDSLSKLTKVDDLRDRIQQLFGVALESQRLFYRGKQMENGHTLFDYSVGLNDIVQLLVRQIPDSFPTKHKECELSDASAGCGSGQRDSDSGSGEGAMDVDGQSISIIGENVGTSLYKKNDLVDARDLNMGAWFEAQIVNVSKKVGPYGTLPEVSDTSVTSDAIIYHVKYEDYPENGVVQLTCKDVRLRARTTLPWHEIKVGQVVMVNYNPDEPKERGYWYDAEILRKHESKKIKEIYAKVLLGDAGDSLNDCRIRFVNEIYKIEEPGSTYLNTESPQKRQNGPECKHCKDNPKRACRMCACCICGGKQDPEKQLLCDECDLAFHIYCLKPPLSVIPQDEDWYCPDCRNDASEVVLAGEKLKESKKKARMASANSSSQRDWGKGMACVGRSRECTIVPSNHYGPIPGVPVGTLWKFRVQVSESGVHRPHVAGIHGRSNDGSYSLVLAGGYEDDVDNGNEFTYTGSGGRDLSGNKRTAEQSCDQKLSNMNRALALNCSAPINDKEGSIAKDWRAGKPVRVVRNSKGRKHSKYAPEEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDYEPAPWSKEGKERIKKLGLTMQYPDGYLETLASKEREKENKTEDEPIDSPSKGKRKRNSDNEQTAAKSIPKKMKVASYKLTLEQKTLIKQDVLNAKLWSEVMLFLKEGPKFVNKVEETFLCICCQEVVYEPVTTECHHNICKGCLDRSFKALVHSCPACRHDLGKNYPLNVNKPLQAILSQLFPGYESGR
What is the function of this protein?
Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification.  Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication.  In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins.  Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication.  Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications.  Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins.  However, it is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo.
What are the official names of this protein?
E3 ubiquitin-protein ligase UHRF1, Nuclear zinc finger protein Np95, XNp95, RING-type E3 ubiquitin transferase UHRF1, Ubiquitin-like PHD and RING finger domain-containing protein 1, Ubiquitin-like-containing PHD and RING finger domains protein 1.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions (By similarity).
Protein: MPC1_DROME
Sequence: MSIRRAMSTTASKEWRDYFMSTHFWGPVANWGIPVAALADTQKSPKFISGKMTLALTLYSCIFMRFAYKVQPRNWLLFACHATNATAQSIQGLRFLHYNYGSKEQQA
What is the function of this protein?
Mediates the uptake of pyruvate into mitochondria.
What are the official names of this protein?
Mitochondrial pyruvate carrier 1, MPC1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: OGG1_SULIM
Sequence: MLRSLVQNPRVRARVLERVDEFRLNNLSNEEVWFRELTLCLLTANSSFISAYQALNCLGDKIYYANEEVIRSILKSCKYRFYNLKAKYIIMAREKVYGKLKEEITPLADSDQQLAREKLLNIKGIGMKEASHFLRNVGYFDLAIIDRHLIDFMRRIGAIGETNVKHLSKSRYISLESVLKSIALNLNISVGILDLFIWYKETNTIVK
What is the function of this protein?
Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA.  Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).
What are the official names of this protein?
8-oxoguanine DNA glycosylase/AP lyase.
What is the protein family that this protein belongs to?
Belongs to the type-2 OGG1 family.
Protein: SYA_BURP0
Sequence: MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLLFTNSGMVQFKDVFLGAETRPYSRATTAQRSVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAIHYAWELLTSVYKLPADKLWVTVYHDDDEAYDIWAKEVGVPAERIIRIGDNKGARYASDNFWQMGDTGPCGPCSEIFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKPCVDTGMGLERIAAVLQHVHSNYEIDLFQQLIKASARETGVADLANNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKLGRKAPFFHKLVADLVAEMGAAYPELKEAEPRVTDVLRQEEERFFETIEHGMSILEAALAELDAAGGKTLDGELAFKLHDTYGFPLDLTADVCRERGVTVDEPAFDDAMARQREQARAAGKFKATQGLEYTGAKTTFHGYEEIAFDDAKVVALYVEGASVGEVKAGESAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVGDTLKVQADVIGHHGELEQGTLKVGDVVRAEIDAARRARTARNHSATHLMHKALRDVLGSHVQQKGSLVDADKTRFDFAHNAPLTDDEIRRVEAIVNEQVLANAPGIVRVMPYDDAVKGGAMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGLFKIVAEGGVAAGIRRVEAITGDNAVRYVQALDARVNAAAAALKAQPSELLQRIGQVQDQVKSLEKELGALKSKLASSQGDELAQQAVEVGGVHVLAATLDGADAKTLRETVDKLKDKLKSAAIVLAAVDGGKVSLIAGVTADASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPAKLPAALAGVKGWVEARL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GWT1_CRYNB
Sequence: MGDYKLAKEAFVSGNPGASIWSINAVSLVALATYALWIALSPYIRHGLLNNYLICVLPLLLGVTIFSTSPLVFASFLSIISLFFIAKSQKRFNFPRSPEKPKGQWLDESDSDEEPAEPASAAGSAAVSPAKLLPSQVAFASGSLLSTDPTISPMSPSSSSSSGHEDPLGIMGVNRRRSPLEGVSLDVPSHIDSKVRISPVPSLRLKKSRATKVQGVEEKGRLPFLTVYRAHMMLMTVICILAVDFEVFPRWQGKCEDFGTSLMDVGVGSFVFSLGLVSTKSLSPPPPPPTPTSPALNSHIIPLTPSPLSFILISLRKSVPVLVLGFIRLIMVKGSDYPEHVTEYGVHWNFFFTLALVPVLAVGVRPLTQWLRWSVLGVIISLLHQLCLTYYLQPIIFSFGRSGIFLANKEGFSSLPGYLSIFLIGLSIGDHVLRLSLPPRRERVVSETIEEHEQSHFERKKLDLIMELIGYSLGWWALLGGWIWAGGEVSRRLANAPYVFWVAAYNTTFLLGYLLLTHIIPSSISSQTSPSILVPRLLDAMNKNGLAVFLAANLLTGLVNVSMETMYAPAWLSMGVLMLYSLAVSCVGWVLKGRSIKI
What is the function of this protein?
Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.
What are the official names of this protein?
GPI-anchored wall transfer protein 1.
What is the protein family that this protein belongs to?
Belongs to the PIGW family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: Y526_LISMF
Sequence: MKLLLKNINELAAKQKSEGLTAFEKERQAALRQEYLKKIRGTVQDNLHHVTIIDPLGDDVTPKKLKEIQAELRG
What are the official names of this protein?
UPF0291 protein LMOf2365_0526.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.