PharMolix/UniProtQA huggingface dataset:
Protein: PCNA_METMA
Sequence: MFKAAINAELLKDAIASLAVIVDEVRFKIKPEGISVKAVDPANVAMGIFELGSSAFEEYSADECEIGIDLNKITDLLGIADRNDTVRMELDEGSNKLLIDVGGLSYTLSLLDPSTIRAEPRVPQLELPAKVVLNGADLRRAVKAAEKISDHMLMGVSGDTFYMEAKGDTDQVRLEMGRDQLIDLKAGEACSLFSLDYLTDIVKPTNKVNEVTLSLGRDFPILIDFEIANGAGRISYLLAPRIESD
What is the function of this protein?
Sliding clamp subunit that acts as a moving platform for DNA processing.  Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
What are the official names of this protein?
DNA polymerase sliding clamp, Proliferating cell nuclear antigen homolog, PCNA.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
Protein: UBID_HAMD5
Sequence: MKYKDLRDFLALLEAKGELKRIHQTIDPFLEMTEISDRTLQAQGPALLFEKPKGHAMPVLCNLFGTTQRVAMGMGQKDISTLRELGQLLAFLKEPEPPKGFRDLLSKLPKFKQILNMPNKILTSAPCQEEIWKDNLDLGCLPAMHCWPGDVAPLITWGLTITRGPHKERQNLGIYRQQVLSKNKIIMRWLPHRGGALDYREWCKTNPGQPFPVAVALGADPATILGAVTPVPDTLSEYAFSGLLRGYRTEVVKCLSSDLQVPANAEIVLEGYIQPGETAEEGPYGDHTGYYNETEHFPVFTVSHITKRQDAIYHSTYTGRPPDEPSILGAALNEVFIPILQKQFPEIVDFYLPPEGCSYRLAVVTIKKQYAGHAKRVMMGVWSFLRQFMYTKFVIVCDDDINARNWNDVIWAITTRMDPARDTLLIENTPIDYLDFASPVAGLGSKMGLDATNKWSAETQRVWGRTIKMDKSVCDRIDAIWDELNIFNQQSVKKK
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL5_BRUAB
Sequence: MAEAKALPRFKKLYQDNIRKALLEEFKYDNEMQIPRITKVVLNMGVGEATGDSKKPAVAAEDLAMIAGQKAVVTRARNSIATFKLREGMPIGAKVTLRQDRMYEFLDRLITIALPRVRDFRGLNPKSFDGRGNYAMGIKEHIVFPEINYDKVDQIWGMDIIVCTTAKTDDEARSLLRAFNFPFRQ
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: NAT5_YEAST
Sequence: MGRDICTLDNVYANNLGMLTKLAHVTVPNLYQDAFFSALFAEDSLVAKNKKPSSKKDVHFTQMAYYSEIPVGGLVAKLVPKKQNELSLKGIQIEFLGVLPNYRHKSIGSKLLKFAEDKCSECHQHNVFVYLPAVDDLTKQWFIAHGFEQVGETVNNFIKGVNGDEQDAILLKKHIS
What is the function of this protein?
N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:25886145).  Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides (PubMed:25886145).  Non-essential component of the NatA N-terminal acetyltransferase (PubMed:14517307).
What are the official names of this protein?
N-alpha-acetyltransferase NAT5, NatA complex subunit NAT5.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALLA_BURCE
Sequence: MSGTPILRVERLTREAFAPFGDVIALEGARHFPINGGTTERFHDLATIDVCADGGRPLVSVFRAQPRAVPVAITLMERHPHGSQAFIPLAAVSRYAIVVAPAGEFRPDAMRAFLAEGWQGVNYAKGVWHHPLLALDAVSDFVIVDRGGPQPNCDEIPLECAWALEFEPACAGAEGLS
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: YBJO_SHIFL
Sequence: MEDETLGFFKKTSSSHARLNVPALVQVAALAIIMIRGLDVLMIFNTLGVRGIGEFIHRSVQTWSLTLVFLSSLVLVFIEIWCAFSLVKGRRWARWLYLLTQITAASYLWAASLGYGYPELFSIPGESKREIFHSLMLQKLPDMLILMLLFVPSTSRRFFQLQ
What are the official names of this protein?
Inner membrane protein YbjO.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSS1_YEAST
Sequence: MNSASFLQSRLISRSFLVRRSLKRYSGLAKPYTFQQPTIYALSTPANQTSAIAIIRISGTHAKYIYNRLVDSSTVPPIRKAILRNIYSPSSCSVKPHDQKESKILLDTSLLLYFQAPYSFTGEDVLELHVHGGKAVVNSILKAIGSLHDRSSGKDIRFALPGDFSRRAFQNGKFDLTQLEGIKDLIDSETESQRRSALSSFNGDNKILFENWRETIIENMAQLTAIIDFADDNSQEIQNTDEIFHNVEKNIICLRDQIVTFMQKVEKSTILQNGIKLVLLGAPNVGKSSLVNSLTNDDISIVSDIPGTTRDSIDAMINVNGYKVIICDTAGIREKSSDKIEMLGIDRAKKKSVQSDLCLFIVDPTDLSKLLPEDILAHLSSKTFGNKRIIIVVNKSDLVSDDEMTKVLNKLQTRLGSKYPILSVSCKTKEGIESLISTLTSNFESLSQSSADASPVIVSKRVSEILKNDVLYGLEEFFKSKDFHNDIVLATENLRYASDGIAKITGQAIGIEEILDSVFSKFCIGK
What is the function of this protein?
GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.  Involved in the expression of cytochrome c oxidase subunit 1 (COX1).  Works in association with the small subunit of mitoribosomes.
What are the official names of this protein?
tRNA modification GTPase MSS1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CAS2_ACIAP
Sequence: MLTGYRLMWMVVMFDLPVITKAERKAATGFRNALLDVGFQMSQFSVYLRFCTSQAQVDTLCRQVEQALPAGGKVHIFQFTDKQYERAISFHGRSRQPAQKAPDQFDLF
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: IHFA_HAEDU
Sequence: MTLTKVEFTASLISKYGFDKSVAKQFVEQFFEEIRVALANGQEVKLSGFGNFSLRKKNARPGRNPKTGESVAVSARRVVVFKPGQKFRERVENVKVKS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: MNTP_ALIB4
Sequence: MLEVLILAFALSMDAFAVSIGLGIKNKQNLKALALKAGLFFGIFQALMPFLGFLGGIGLREYIQGYDKIVAFILLLAIGGKMIYEAFNENVEEEISQITNKILLTLAIATSLDAMAAGYSLHLFNLNIYLSLFVIGFTTFIISYIGVYVGSRGGEKYESKAEILGGVVLILIGLKILLF
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CSF2_PIG
Sequence: MWLQNLLLLGTVVCSISAPTRPPSPVTRPWQHVDAIKEALSLLNNSNDTAAVMNETVDVVCEMFDPQEPTCVQTRLNLYKQGLRGSLTRLKSPLTLLAKHYEQHCPLTEETSCETQSITFKSFKDSLNKFLFTIPFDCWGPVKK
What is the function of this protein?
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
What are the official names of this protein?
Granulocyte-macrophage colony-stimulating factor, GM-CSF, Colony-stimulating factor, CSF.
What is the protein family that this protein belongs to?
Belongs to the GM-CSF family.
What are the subcellular locations of this protein?
Secreted.
Protein: IF1_SACD2
Sequence: MAKEDNFELEGEVIDTLPNTTFRVKLENGHVVTAHISGKMRKNYIRILTGDKVKVEMTPYDLSKGRITYRAR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMC4_ARATH
Sequence: MEEDEPMGGGESEPEQRKSGTPRLYIKELVMRNFKSYAGEQRVGPFHKSFSAVVGPNGSGKSNVIDAMLFVFGKRAKQMRLNKVSELIHNSTNHQNLDSAGVSVQFEEIIDLENGLYETVPGSDFMITRVAFRDNSSKYYINERSSNFTEVTKKLKGKGVDLDNNRFLILQGEVEQISLMKPKAQGPHDEGFLEYLEDIIGTNKYVEKIDELNKQLETLNESRSGVVQMVKLAEKERDNLEGLKDEAETYMLKELSHLKWQEKATKMAYEDTVAKITEQRDSLQNLENSLKDERVKMDESNEELKKFESVHEKHKKRQEVLDNELRACKEKFKEFERQDVKHREDLKHVKQKIKKLEDKLEKDSSKIGDMTKESEDSSNLIPKLQENIPKLQKVLLDEEKKLEEIKAIAKVETEGYRSELTKIRAELEPWEKDLIVHRGKLDVASSESELLSKKHEAALKAFTDAQKQLSDISTRKKEKAAATTSWKADIKKKKQEAIEARKVEEESLKEQETLVPQEQAAREKVAELKSAMNSEKSQNEVLKAVLRAKENNQIEGIYGRMGDLGAIDAKYDVAISTACAGLDYIVVETTSSAQACVELLRKGNLGFATFMILEKQTDHIHKLKEKVKTPEDVPRLFDLVRVKDERMKLAFYAALGNTVVAKDLDQATRIAYGGNREFRRVVALDGALFEKSGTMSGGGGKARGGRMGTSIRATGVSGEAVANAENELSKIVDMLNNIREKVGNAVRQYRAAENEVSGLEMELAKSQREIESLNSEHNYLEKQLASLEAASQPKTDEIDRLKELKKIISKEEKEIENLEKGSKQLKDKLQTNIENAGGEKLKGQKAKVEKIQTDIDKNNTEINRCNVQIETNQKLIKKLTKGIEEATREKERLEGEKENLHVTFKDITQKAFEIQETYKKTQQLIDEHKDVLTGAKSDYENLKKSVDELKASRVDAEFKVQDMKKKYNELEMREKGYKKKLNDLQIAFTKHMEQIQKDLVDPDKLQATLMDNNLNEACDLKRALEMVALLEAQLKELNPNLDSIAEYRSKVELYNGRVDELNSVTQERDDTRKQYDELRKRRLDEFMAGFNTISLKLKEMYQMITLGGDAELELVDSLDPFSEGVVFSVRPPKKSWKNIANLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFKNVSIVGHYVKDRTKDAQFIIISLRNNMFELADRLVGIYKTDNCTKSITINPGSFAVCQKTPA
What is the function of this protein?
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.  The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.  Also involved in chromosome segregation in meiosis.
What are the official names of this protein?
Structural maintenance of chromosomes protein 4, AtSMC4, SMC protein 4, SMC-4, Chromosome-associated protein C, AtCAP-C.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC4 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with chromatin.
Protein: TNFA_CAVPO
Sequence: MSTESMIRDVELAEEQLPKKAGGPQGSRRCWCLSLFSFLLVAGATTLFCLLHFGVIGPQREEQFSSGPPFRPLAQTLTLRSASQNDNDKPVAHVVANQQAEEELQWLSKRANALLANGMGLSDNQLVVPSDGLYLIYSQVLFKGQGCPSYLLLTHTVSRLAVSYPEKVNLLSAIKSPCQKETPEGAERKPWYEPIYLGGVFQLQKGDRLSAEVNLPQYLDFADSGQIYFGVIAL
What is the function of this protein?
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
What are the official names of this protein?
Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted. SUBCELLULAR LOCATION: [C-domain 1]: Secreted. SUBCELLULAR LOCATION: [C-domain 2]: Secreted.
Protein: PSD_BACCR
Sequence: MRRTLYRLMIELTNGRFTSYILRKFAQSRLSSIIIPSYAKVFQINQDEMEKGLKEYRTLHELFTRKLKEGKRSIDTDASSIVSPVDGVFADHGPIEDTKTFDIKGKRYSIVDMLGNEERATRYAGGTYMVIYLSPSHYHRIHSPLSGSVTERFVLGRKSYPVNAAGMEYGKEPLSKNYRSVTEVSSDGEHMALVKVGAMFVNSIELLHERDTVQKGEEMAYFTFGSTVVLLFEKDMIEVVQELKSGQELRLGEKIATRLAHK
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PLMT_SCHPO
Sequence: MSLILYPKPTSYLYQPFIKAYFSLNMAIFEINNSFLICAVSIALNPLLWNIAARSEYNHKTLTKLANGDSKKACYMLAACIFVAGIVRDLIYQNALKQQPTLGIFMNPLVQGIAKLIFCFGSVLVLSSMYKLGLVGTYLGDYFGFLLPERVSGFPFNVNDNPMYNGSTLCFLSTALRYGKVAGLLLTLEVFFVYRIALKFEEPFTAKIYAARDSKQAKKSE
What is the function of this protein?
Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
What are the official names of this protein?
Phosphatidyl-N-methylethanolamine N-methyltransferase, Phospholipid methyltransferase, PLMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi- pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Protein: PSAA_PROMP
Sequence: MTISPPESGEKDKKILESPVKADPRPIDFAKLDKPGFWSSKLSKGPKTTTWIWNLHADAHDFDIHTGDAEEATRKIFSAHFGHLAVIFIWMSAAFFHGARFSNYSGWLADPTHVKPGAQQVWAIVGQEMLNGDLGANYNGIQISSGVFHMWRAWGITNESELMALAIGAVVMAALMLHAGIFHYHKAAPKMEWFQNIESMLNHHIAGLVGLGSLAWAGHCIHIGAPTAALLDAIDAGTPLVINGKEIATIADMPMPHQLCDPQIIAQIFPGLASGTGNFFSLNWLAFSDFLTFKGGLNPVTGSLWMTDVSHHHLAFGVIAIIGGHMYRTNYGIGHSMKEILDSQQGDPILFPAPKGHQGLFEFMAESRHAQLSVNLAMLGSLSILISHHMYAMPPYPYIATDYMTVLGLFTHHMWIGGLFIVGAGAHAGIAMVRDYDPAKHIDNVLDRILKARDALISHLNWVCMWLGFHSFGLYIHNDTMRALGRPQDMFSDSAIQLQPIFAQWVQSIQASAVGTSILAGTAEALPHKAISEVFNGSLVEVGGKVAIAPIPLGTADLMIHHIHAFQIHVTVLILLKGVLYARSSRLIPDKASLGFRFPCDGPGRGGTCQVSSWDHVFLGLFWMYNCLSIVIFHFSWKMQSDVWGLTGGNFSQSAITINGWLRDFLWAQSSQVLTSYGSAISMYGLMFLGAHFIWAFSLMFLFSGRGYWQELFESIVWAHNKLKVAPTIQPRALSITQGRAVGVTHFLVGGIATTWAFFHARLFGLG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: LEXA_PSECL
Sequence: MLKLTPRQAEILAFIKRCLEDNGYPPTRAEIAQELGFKSPNAAEEHLKALARKGAIEMTPGASRGIRIPGFEAKPDDSSLPIIGRVAAGAPILAEQHIEESCNINPAFFHPRADYLLRVHGMSMKDIGIFDGDLLAVHTTREARNGQVVVARIGDEVTVKRFKREGSKVWLIAENPEFAPIEVNLKDQDLVIEGLSVGVIRR
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: DHRS6_MOUSE
Sequence: MGRLDGKVIVLTAAAQGIGRASALAFAREGAKVIATDINESKLQELESYRGIQTRVLDVTKKRQIDQFASEIERIDVLFNVAGFVHHGTILDCEEKDWDFSMNLNVRSMFLMIKAFLPKMLAQKSGNIINMSSVASSIKGVENRCVYSATKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARDNPKEALKTFLNRQKTGRFASAEEVALLCVYLASDESAYVTGNPVIIDGGWSL
What is the function of this protein?
(Microbial infection) May play a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria.  Host iron-siderophore complexes can be used by bacteria to promote their own growth and pathogenicity.
What are the official names of this protein?
Dehydrogenase/reductase SDR family member 6, (R)-beta-hydroxybutyrate dehydrogenase, 3-hydroxybutyrate dehydrogenase type 2, 4-oxo-L-proline reductase, Oxidoreductase UCPA, Short chain dehydrogenase/reductase family 15C member 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: HCST_BOVIN
Sequence: MVPPGNILFLLLLPVATAQMTPGSCSGCGPLSLPLLAGLVAADAVVSLLIVVVVFVCARLRSRPTQEDDKIYINMPGRG
What is the function of this protein?
Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation.  Functions as docking site for PI3-kinase PIK3R1 and GRB2.  Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways.  Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells.  In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors.  In T-cells, it provides primarily costimulation for TCR-induced signals.  KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity).
What are the official names of this protein?
Hematopoietic cell signal transducer, DNAX-activation protein 10, Membrane protein DAP10.
What is the protein family that this protein belongs to?
Belongs to the DAP10 family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: GLHA1_ONCKE
Sequence: SLILSILLYMADSYQNSDMTNVGCEECKLKENKVFSNPGAPVYQCTGCCFSRAYPTPLQSKKAMLVPKNITSEATCCVAKEGERVVVDNIKLTNHTECWCNTCYHHKS
What is the function of this protein?
Involved in gametogenesis and steroidogenesis.
What are the official names of this protein?
Glycoprotein hormones alpha chain 1, GTH-alpha, Gonadotropin 1 alpha chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit alpha family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1583_MYCTO
Sequence: MTAGAGGSPPTRRCPATEDRAPATVATPSSADPTASRAVSWWSVHEHVAPVLDAAGSWPMAGTPAWRQLDDADPRKWAAICDAARHWALRVETCQEAMAQASRDVSAAADWPGIAREIVRRRGVYIPRAGVA
What are the official names of this protein?
Uncharacterized protein MT3573.2.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv2656c.
Protein: F16A1_CUPMC
Sequence: MTRISLTRYLVEEQRKHNTIEPELRLLIEVVARACKAISNAVSKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLDANEWGGHLAAMASEEMDSFYEIPNRYPKGEYLLLFDPLDGSSNIDVNVSIGTIFSVLHMHKPGQTVTEHDFMQPGTQQVAAGYAVYGPQTTLVLTVGNGVHMFTLDREAGSFVLTQSDVMIPEDTKEFAINMSNMRHWAPPVRRYIDECLAGDEGPRGKNFNMRWIASMVADVHRILTRGGVFMYPWDKREPEKPGKLRLMYEANPMAFLVEQAGGAATNGQQRILDVEPTKLHQRVSVILGSKNEVERVTRYHQEDAAKA
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1 1, FBPase class 1 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNC_ECO8A
Sequence: MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHSEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PROF1_MOUSE
Sequence: MAGWNAYIDSLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVSITPAEVGVLVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNVTVTMTAKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG.  Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity).
What are the official names of this protein?
Profilin-1, Profilin I.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RLME_SORC5
Sequence: MPAERPSVSQKPKNPYKRPDAFTKAAKAQGYPARSVFKLEEIDRRVRLLRPGQRVLDLGAAPGSWSMYAAQRIGAGGKLLAVDLSPITAAFGPQATVVQGDALSLTNEALAQFAPYDVVLSDMAPATSGSKIADQARSYELFMRAVAVAEALLAPGGAFVGKIFMSEDFVKARDALRNLCEEVRSIRPEGTRASSVEIFLVGLKRKAAGKTG
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZYX_CHICK
Sequence: MASPGTPGTRMTTTVSINISTPSFYNPQKKFAPVVAPKPKVNPFKTGGTSESSQPQPPGTGAQRAQIGRVGEIPVSVTAEELPLPPPPPPGEELSFSSNCAFPPPPPPFEEPFPPAPDEAFPSPPPPPPPMFDEGPALQIPPGSTGSVEKPLAPKAHVEISSAPRDPTPPFPSKFTPKPSGTLSSKPPGLDSTPAPAPWAAPQQRKEPLASVPPPPSLPSQPTAKFTPPPVASSPGSKPGATVPMAPSNSTRYPTSLQTQFTAPSPSGPLSRPQPPNFTYAQQWERPQVQEKPVPTEKSAAVKDMRRPTADPPKGNSPLTMKEVEELELLTQKLMKDMDHPPPVEAATSELCGFCRKPLSRTQPAVRALDCLFHVECFTCFKCEKQLQGQQFYNVDEKPFCEDCYAGTLEKCSVCKQTITDRMLKATGNSYHPQCFTCVMCHTPLEGASFIVDQANQPHCVDDYHRKYAPRCSVCSEPIMPEPGKDETVRVVALEKNFHMKCYKCEDCGRPLSIEADENGCFPLDGHVLCMKCHTVRAKTAC
What is the function of this protein?
Adhesion plaque protein.  Binds alpha-actinin and the CRP protein.  May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.
What are the official names of this protein?
Zyxin.
What is the protein family that this protein belongs to?
Belongs to the zyxin/ajuba family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1 (By similarity).