PharMolix/UniProtQA huggingface dataset:
Protein: RPE65_HUMAN
Sequence: MSIQVEHPAGGYKKLFETVEELSSPLTAHVTGRIPLWLTGSLLRCGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEFGTCAFPDPCKNIFSRFFSYFRGVEVTDNALVNVYPVGEDYYACTETNFITKINPETLETIKQVDLCNYVSVNGATAHPHIENDGTVYNIGNCFGKNFSIAYNIVKIPPLQADKEDPISKSEIVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYMDCFESNETMGVWLHIADKKRKKYLNNKYRTSPFNLFHHINTYEDNGFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKKNARKAPQPEVRRYVLPLNIDKADTGKNLVTLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQINYQKYCGKPYTYAYGLGLNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFVSHPDALEEDDGVVLSVVVSPGAGQKPAYLLILNAKDLSEVARAEVEINIPVTFHGLFKKS
What is the function of this protein?
Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins.  Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091).  Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510).  Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556).  The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester.  The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol.  The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).
What are the official names of this protein?
Retinoid isomerohydrolase, All-trans-retinyl-palmitate hydrolase, Lutein isomerase, Meso-zeaxanthin isomerase, Retinal pigment epithelium-specific 65 kDa protein, Retinol isomerase.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor. Microsome membrane. Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated. Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells.
Protein: ATP23_ASPNC
Sequence: MSTSESSNNGSQPGNQDTGYIPGDDTWTQWRNIFSILAGRMTDEGKEQFRVARDIRNEVADCKRCEDQRDYLLQFSPIIRFMSDSIRQLGGDLHSHNIYCRRCTNRKAGGFDPDYGILICANEMKDQGHLEDTMAHEMVHAYDHLRFKVDWMNNLRHAACTEIRASSLSGECRWAREFFRRGQWKFTQQHQECVRRRAILSVRARPGCKDEAHAEKVVNEVWDSCFRDTRPFDEIYR
What is the function of this protein?
Has a dual role in the assembly of mitochondrial ATPase.  Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side.  Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring (By similarity).
What are the official names of this protein?
Mitochondrial inner membrane protease atp23.
What is the protein family that this protein belongs to?
Belongs to the peptidase M76 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Associates loosely with the inner membrane.
Protein: STK40_RAT
Sequence: MKRRASDRGAGETSAKAQALGTGIAGNNAKRAGPFILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLEERGEQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEAVEDTESGRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIASWQSLSSLSGPLQVVPDIDDQMSSSDSSQEAKVTEECSQYEFENYMRQQLLLAEEKSSIHEARAWVPKRQFGSMPPVRRLGHDAQPMTSLDTAILAQRYLRK
What is the function of this protein?
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
What are the official names of this protein?
Serine/threonine-protein kinase 40, Serine/threonine-protein kinase lyk4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RL15_POLNA
Sequence: MELNTITPGQGAKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGYHKVGFEGGQMPMQRRLPKRGFKSHLLKFNAEVTLTALEQLGLAEVDLLTLKQSGLVGQIAKNVKIINTGSLSLAVKLTGISATAGAKTIIEAAGGSIA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ELAV2_HUMAN
Sequence: METQLSNGPTCNNTANGPTTINNNCSSPVDSGNTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKTNQAILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKRFSPMTIDGMTSLAGINIPGHPGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKA
What is the function of this protein?
RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity).  Seems to recognize a GAAA motif (By similarity).  Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity).
What are the official names of this protein?
ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigen B, HuB, Nervous system-specific RNA-binding protein Hel-N1.
What is the protein family that this protein belongs to?
Belongs to the RRM elav family.
Protein: Y910_MYCTU
Sequence: MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLNGDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Upon expression in M. smegmatis inhibits colony formation.  Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0909.  Does not exert its toxic effect via translation.
What are the official names of this protein?
Toxin Rv0910.
Protein: ARFG_ARATH
Sequence: MKAPSSNGVSPNPVEGERRNINSELWHACAGPLISLPPAGSLVVYFPQGHSEQVAASMQKQTDFIPSYPNLPSKLICMLHNVTLNADPETDEVYAQMTLQPVNKYDRDALLASDMGLKLNRQPNEFFCKTLTASDTSTHGGFSVPRRAAEKIFPALDFSMQPPCQELVAKDIHDNTWTFRHIYRGQPKRHLLTTGWSVFVSTKRLFAGDSVLFIRDGKAQLLLGIRRANRQQPALSSSVISSDSMHIGVLAAAAHANANNSPFTIFYNPRAAPAEFVVPLAKYTKAMYAQVSLGMRFRMIFETEECGVRRYMGTVTGISDLDPVRWKNSQWRNLQIGWDESAAGDRPSRVSVWDIEPVLTPFYICPPPFFRPRFSGQPGMPDDETDMESALKRAMPWLDNSLEMKDPSSTIFPGLSLVQWMNMQQQNGQLPSAAAQPGFFPSMLSPTAALHNNLGGTDDPSKLLSFQTPHGGISSSNLQFNKQNQQAPMSQLPQPPTTLSQQQQLQQLLHSSLNHQQQQSQSQQQQQQQQLLQQQQQLQSQQHSNNNQSQSQQQQQLLQQQQQQQLQQQHQQPLQQQTQQQQLRTQPLQSHSHPQPQQLQQHKLQQLQVPQNQLYNGQQAAQQHQSQQASTHHLQPQLVSGSMASSVITPPSSSLNQSFQQQQQQSKQLQQAHHHLGASTSQSSVIETSKSSSNLMSAPPQETQFSRQVEQQQPPGLNGQNQQTLLQQKAHQAQAQQIFQQSLLEQPHIQFQLLQRLQQQQQQQFLSPQSQLPHHQLQSQQLQQLPTLSQGHQFPSSCTNNGLSTLQPPQMLVSRPQEKQNPPVGGGVKAYSGITDGGDAPSSSTSPSTNNCQISSSGFLNRSQSGPAILIPDAAIDMSGNLVQDLYSKSDMRLKQELVGQQKSKASLTDHQLEASASGTSYGLDGGENNRQQNFLAPTFGLDGDSRNSLLGGANVDNGFVPDTLLSRGYDSQKDLQNMLSNYGGVTNDIGTEMSTSAVRTQSFGVPNVPAISNDLAVNDAGVLGGGLWPAQTQRMRTYTKVQKRGSVGRSIDVNRYRGYDELRHDLARMFGIEGQLEDPQTSDWKLVYVDHENDILLVGDDPWEEFVNCVQSIKILSSAEVQQMSLDGNFAGVPVTNQACSGGDSGNAWRGHYDDNSATSFNR
What is the function of this protein?
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).  Acts as a transcriptional activator of several tropic stimulus-induced (TSI) genes, including SAUR50.  Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.  Required for differential growth responses of aerial tissues.  Involved in ethylene responses.  Regulates lateral root formation through direct regulation of LBD16 and/or LBD29 (PubMed:29184030).  Functionally redundant with ARF19 (PubMed:29184030).  Mediates embryo axis formation and vascular tissues differentiation.  Functionally redundant with ARF5.  Involved in cellular dedifferentiation during callus formation on callus-inducing medium (CIM) and in an ATXR2-dependent manner (PubMed:29184030).
What are the official names of this protein?
Auxin response factor 7, Auxin-responsive protein IAA21/IAA23/IAA25, Protein BIPOSTO, Protein MASSUGU 1, Protein NON-PHOTOTROPIC HYPOCOTYL 4, Protein TRANSPORT INHIBITOR RESPONSE 5.
What is the protein family that this protein belongs to?
Belongs to the ARF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y916_BACC4
Sequence: MTKNIHDVAYELQKAIAENEDFKTLKESYAAVQADTASKNLFDEFRTMQLSLQQKMMQGQEITEEDNQQAQEVVARIQQDAKITKLMETEQRLNVVIGDVNKIIMKPLEELYSAQQQA
What are the official names of this protein?
UPF0342 protein BCB4264_A0916.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: ALGI_PSEFL
Sequence: MVFSSNVFLFLFLPIFLGLYYLSGQRYRNLLLLLASYVFYAWWRVDFLALFAAVTLWNYWIGLKVGAAGVRTKPAQRWLLLGVVVDSINVMMKSAGLEPFILTHVLLPIGISFYIFESISYIIDVYRGDTPATRNLIDFAAFVAIFPHLIAGPVLRFRDLADQFNNRTHTLDKFSEGCTRFMQGFIKKVFIADTLAVVADHCFALQNPTTGDAWLGALAYTAQLYFDFSGYSDMAIGLGLMMGFRFMENFKQPYISQSITEFWRRWHISLSTWLRDYLYITLGGNRKGTLTTYRNLFLTMLLGGLWHGANITYIVWGAWHGMWLAIEKAIGLNTSPRSFNPVRWAFTFLLVVMGWVIFRAENLHVAGRMYGAMFSFGEWSLSELNRANLTGLQVATLVVAYATLAFFGLRDFYTNRPAEKTKPADPSLIKAVPGDNPGSIHEPGFTVGQDAAVQPAYWTADWPRYAMRAAVLLLFVASILKLSAQSFSPFLYFQF
What is the function of this protein?
Together with AlgJ and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues.  Acetylation of alginate is important for the architecture of biofilms and increases the ability of alginate to act as a defense barrier (By similarity).
What are the official names of this protein?
Probable alginate O-acetylase AlgI, Alginate biosynthesis protein AlgI.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MDHC_YEAST
Sequence: MPHSVTPSIEQDSLKIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALYDVNQEAINGVTADLSHIDTPISVSSHSPAGGIENCLHNASIVVIPAGVPRKPGMTRDDLFNVNAGIISQLGDSIAECCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIERRIMGVTKLDIVRASTFLREINIESGLTPRVNSMPDVPVIGGHSGETIIPLFSQSNFLSRLNEDQLKYLIHRVQYGGDEVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNIEQIHGTYYVPLKDANNFPIAPGADQLLPLVDGADYFAIPLTITTKGVSYVDYDIVNRMNDMERNQMLPICVSQLKKNIDKGLEFVASRSASS
What is the function of this protein?
The isoenzyme MDH2 may function primarily in the glyoxylate cycle.
What are the official names of this protein?
Malate dehydrogenase, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPN1_RAT
Sequence: MEAPIVLLLLLWLALAPTPGSASSEAPPLVNEDVKRTVDLSSHLAKVTAEVVLAHPGGGSTARASSFVLALEPELESRLAHLGVQVKGEDEEDNNLEVRETKMKGKSGRFFTVKLPVALDPGSKISIVVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVRLASRNVESHTKLGNPSRSEDILDYGPFKDIPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFGLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIQVDSPYDISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRLGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKAVTSEIAVLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLSSGKRQELVTKIDHILDAL
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit, Ribophorin I, RPN-I, Ribophorin-1.
What is the protein family that this protein belongs to?
Belongs to the OST1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome.
Protein: DSBB_ACISJ
Sequence: MLNWIDTAPRRILALISAACVAMLAFGMYLQHVVGLEPCPMCIVQRYALIGVAVFAGLASARGQKGWWMTWSVLALVAAGFGAFVAARQSWLQWYPPEIATCGRDFYGMIENYPISRAIPMIFRGSGDCTAVDWTFLGGSIANWSFVWFLLFAVLLLVLLVRGGRGAPDTLARA
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PP2C_LEICH
Sequence: MGIPLPKPVMTQLQERYGNAIFRCGSNCVNGYRETMEDAHLTYLTDSWGFFGVFDGHVNDQCSQYLERAWRSAIEKESIPMTDERMKELALRIDQEWMDSGREGGSTGTFFVALKEGNKVHLQVGNVGDSRVVACIDGVCVPLTEDHKPNNEGERQRIENCAGRVENNRVDGSLAVSRAFGDREYKLGSGSQLEQKVIALADVQHKDFTFDSNDFVLLCCDGVFEGNFPNEEVVAYVKQQLETCNDLAEVAGRVCEEAIERGSRDNISCMIVQFKDGSDYAAEPHTTVVPGPFSAPRNSGFRKAYESMADKGNTTVGALLERRYDTLKAAEALTPEETEELSQFENGPEAKLTGAERQKWFSNYFQKLCEAASNGPSDQMERLQSLQQQAGIPLSILLSLMGEQTQ
What is the function of this protein?
Enzyme with a broad specificity.
What are the official names of this protein?
Protein phosphatase 2C, PP2C.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: RL31_ACIAD
Sequence: MRADIHPKYQTLVATCSCGNVIETRSALGKETLYLDVCSACHPFYTGKQKNVDTGGRIDKFKQRFSGMSRSIKR
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RL30_HAEIG
Sequence: MAKTIKVTQVRSSIARLPKHKATLRGLGLRHMHHTVELIDTPAVRGMINQVSYMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RL21_STRT2
Sequence: MSTYAIIKTGGKQVKVEVGQAIYVEKINAEAGSEVTFNEVVLVGGDKTVVGTPVVEGATVVGTIEKQGKQKKVVTFKYKPKKGSHRKQGHRQPYTKVVINAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RL29_DESVH
Sequence: MKAAELRKLTAEELKTKLVEQQQELFNLRFRHATAQLENTSSMGDARRTIARIQTILKEKE
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: Y3448_RHORT
Sequence: MGRSASLLRLRDPAPLPTDIAPDPAEAPPSPAADRRVIVVTGMSGAGRTTVLRALEDIGYEAVDNLPLSLFEALTQGRWDQPRPLVLGIDTRTRGFHAATVLAAIERLVAATGFDVRLLFIDCDDEVLVRRYTETRRRHPLAVDRPLADGIALERALVAPLKERASRCLDTSILPPAKLRAVIEAEFSLDHRPELAIFVSSFGFRNGLPREADLVFDVRFLANPHYEPHLREMTGLDPAVAAYVAADPDFAPLIDRVTALLALLVPRYEKEGKSYLTIAIGCTGGKHRSVYTAERLAAWLNETGRRAHVRHRDLKETPR
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Rru_A3448.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: PSBJ_GOSHI
Sequence: MADTTGRIPLWIIGTVTGIPVIGLIGIFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: IF2_RHOBA
Sequence: MPVRIYALAKELNLDSKELVDVVKKAGITGKGSALASLSDEEAQQVRGHLAGSAAKSEPKPKAAPPTKDTPTAPVAPVRDLSGATGRKPSAINVGRPSKPAEAADNPNAPAQPIRDGGRPVGKPAPIVRTPKLAPAPEAKAPEAPAADGSPKPEIRLPKTGGVGTGMASPSGRGIGMGAKTDGQSTKPESAASAPSVPGPKSDSGGRKAPESPKRESAPVASSDDDGSSNKGGGLASRIAGRMGNNSSGRVVPNTPGTPLSAVRRDSASAGGKMRSLDRSRNRPEEAAKAGDAGKSKKREPRIKVNLAQLPSAPAKPAAPTGSSGPAAQKPDIKLTRDVIEGHKQGMKAPLARLEQDEADKKQRSKKTAEGTVGLAGRGKRVIDEDEKPKKKGLAGMASARAERQRGGGGRRIVGSDGGDRHHYRRSRPRIRRKGVNTAAPRKEKVQIELPCTVRNFCEGSGLSVADVMRTLMGMGMMVNINADIDFETAELLATEHDLDIELKAAESLEQELITEIEETADDPDTLVARPPVVTFLGHVDHGKTSLLDHLVGINVVKGEAGGITQHIRAYKIDKDGRAVTFVDTPGHEAFTEMRARGANVTDIAVLVVAADDGIMPQTEEAISHAKAAEVPIVVALNKIDLEGVDANRVMTQLTEHQLTPSEWGGDVEIVRTSATQGTGMDELLDTLLTIAELNEYSANPNRSALGVCLESEQQGDRGVVAKLIVQNGTLRVGDILVCGPAHGRVRAMQDTLTGKPITEAGPSTPVSLMGLDTPPGAGDRFHVLKDISQAREIASAREGESSRQSLSGITTKVSFDSFQEMLEDGKLGESADTVKLNLIIRADARGSLEAIDKELSKFDHPEVEIRVLQRSVGGISLADATLASASDAVILGFNVIPDDKARSLAEERGVEIRRYDVIYKLTDDIRALIEGRLKPEERVVELGRALVKQVFSISRVGTIAGCYVAQGSIQRNCRIRVNRDGRTIGDYQLDTLRRIKEDVKEVPRGMECGIRLQGFNDIKQDDVLEAYKIEEVARKLD
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYD_LACCB
Sequence: MSKRTCYAGDVTAEYVDQEVTLKGWVQKRRSLGSLIFIDLRDREGIVQLVFSEEFDKDALAVANSVRSEYVIEVQGVVKKRKPQAVNKDMKTGDVEVEVHTITILNKAKTPPFYIEDGVAVTEETKLKYRYLDLRRPEMQKNIFTRAHIMRSVHHFLDDNGFIDVETPTLTASTPEGARDYLVPSRVYPGSFYALPQSPQLFKQLLMGAGFDRYYQIARCFRDEDLRGDRQPEFTQIDLETSFLTAEEIQDITEGLIAKVMHDVKGIDVKLPFDRITWQDAMDKYGSDKPDLRFDMQIQDVSELVKDSDFKVFAGAVQNGGQVRAIVLPGGADKYSRKMIDAQQDYIKRFGAKGLAWLKVTSDSISGPIAKFFGDGADLVKAVGANAGDLVLFVADKAKVVADALGYLRTHFGHDLGLIDEQAFRFCWVVDWPLFEYDEGIQRWVPAHHPFTMPNEEDVHLLDTDPHAAHAQSYDIVLNGYELGGGSIRIHNREIQGKMLKALGFTPERAQKSFGFLLNALDYGFPPHGGLAIGLDRFVMLLTGRDNIRDVIAFPKNSKASEPMTSAPYPVADAQLKDLGIEVRADVDPEKEHEGDENLTE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_MYCTO
Sequence: MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGALTAATSAGSTLGEHHPHLTPLAHRVVEPTEAAVLGGHDAVFLALPHGHSAVLAQQLSPETLIIDCGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYPTAALLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPEIAQGLRAVTDRDVSVSFTPVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYLMPEGQLPRTGAVIGSNAAHIAVAVDEDAQTFVAIAAIDNLVKGTAGAAVQSMNLALGWPETDGLSVVGVAP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBCD1_DROME
Sequence: MALKRINKELQDLGRDPPAQCSAGPVGDDLFHWQATIMGPPDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNELAREWTRKYAM
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Mediates the selective degradation of short-lived and abnormal proteins.  Required for proper telomere behavior during cell divisions and possibly for ubiquitination of proteins involved in postmeiotic stages of spermatogenesis.  Deletion mutations are lethal in homozygotes.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2-17 kDa, E2 ubiquitin-conjugating enzyme D1, Protein effete, Ubiquitin carrier protein, Ubiquitin-protein ligase.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: LEPA_ORITI
Sequence: MQQQSNIRNFAIIAHIDHGKSTLADRLIEYCNALEAREMCQQVLDSMDIEKERGITIKAQTVRLVYKADDGCVYHLNLMDTPGHVDFAYEVSRSLAACESSLLVVDASQGVEAQTLANLYQAVDNNHKILIVLNKIDLPAANPQQVQQQIEDVIGIDASDALMISAKIGLGIKDVLQAIVTKLPSPNGDSQSQLKALLIDSWYDSYLGVVILVRVVDGKIEKGMRIRMCSNNAVYTVENVGFFSPKKQISGVLYTGEIGFVTAAIKQVADCRVGDTITDDKKPCAQILPGFKPNLPVVFCGLYPSDASQFNHLKDSLQKLRLNDASFEFEQESSGALGFGFRCGFLGLLHLEIIQERLEREFDLDMITTAPSVMYKVYLNTGKVIDVHNPADLPEMQKIKSMSEPWVEATIFIPDQYLGAILGLCTEKRGVQVDLTYVNGRAKLVYLLPLNEIVFDFYDKLKSYSKGYASFDWQMNSYKQSDLIKLSILVNGNPVDALSTIVHRSKAEFRGRELCKRLKDLIPAHLFQIAIQAAIGSRIIARETIRALRKDVLAKCYGGDITRKRKLLEKQKAGKKRMRNIGNVEIPQSAFIAALKITNKD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.