PharMolix/UniProtQA huggingface dataset:
Protein: ERCC3_MOUSE
Sequence: MGKRDRVDRDKKKSKKRQYEEEEEDEDDIPGNESQEAVPSAAGKQVDESSTKVDEYGAKDYRQQMPLKGDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIIQFIKLCTVSYGKVKLVLKHNRYFVESSHPDVIQHLLQDPVIRECRLRNAEGEATELITETFTSKSAISKTAAEGSGGPSTSQGVDAQATSDIPKDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCICLEYPLLAEYDFRNDTLNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPARMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEELAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSGQASRRCGTMSSLSGADDTVYMEYHSSRSKASSKHVHPLFKRFRK
What is the function of this protein?
ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH helicase subunit XPB, TFIIH subunit XPB, Basic transcription factor 2 89 kDa subunit, BTF2 p89, DNA excision repair protein ERCC-3, DNA repair protein complementing XP-B cells, TFIIH 89 kDa subunit, Xeroderma pigmentosum group B-complementing protein.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RAD25/XPB subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYK_THEPX
Sequence: MSNSNDNIWNNTEELNELLRIRREKLNILRSMGIEPYGIDRFERTNVSSDIKNDYENFEGKVVTLAGRIMSKRAHGKASFADIQDRDGRIQIYVKYDTVGEKNYEIFKILDIGDIIGVTGEVFKSKTGEITIRVTDFKLLSKSLQILPEKWHGLKDPDLRYRQRYTDLIINPEVKEVFLKRTKIIKAIREFLDNRGFLEVETPILHTIAGGAAARPFITHHNALDIDMYLRIALELHLKRLIVGGLEKVYEMGRVFRNEGMDIRHNPEFTLLELYEAYTDYYGMMELTEQLFAYVAQKVNGTTKIVYQGTEIDLTPPWKRITMVDAIKEYVGVDFNEVKADAEAVEIAKRLNLETKEGMKKGEVIALVFDELVEQHLIQPTFVMDYPVEISPLAKRKHDNPAFTSRFEAFIYGREVANAFSELNDPIDQKERFLEQLKQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFMTDAYSIRDVILFPTMKPKND
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_MYCSK
Sequence: MLRSHAAGSLRPADAGQNVTLAGWVARRRDHGGVIFIDLRDASGVSQVVFREGAVLEAAHRLRAEFCVAVEGVVEVRPEGNENPEIPTGGIEVNATSLTVLGESAPLPFQLDDEAGEEARLKYRYLDLRREGPGKALRLRSKVNAAAREVLARHDFVEIETPTMTRSTPEGARDFLVPARLQPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDADDVIAVSEEILKALWALIGHDLPTPLPRITYAEAMHRFGTDKPDLRFGLELVECKEFFADTTFRVFQAPYVGAVVMPGGASQPRRTLDGWQEWAKQRGAKGLAYVLVGDDGTLGGPVAKNLTDAERDGLAAHVGANPGDCIFFAAGPPKSSRALLGAARIEIAKRLDMIDPDAWAFTWVVDWPLFEMAEDATAAGDVAVGSGAWTAVHHAFTAPQPQSEATFDTDPAGALADAYDIVCNGNEIGGGSIRIHRRDVQERVFAMMGIEHDEAQEKFGFLLDAFTFGAPPHGGIAFGWDRITALLARMDSIREVIAFPKSGGGADPLTGAPAPITPQQRRESGIDAKPKKDGE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_THEON
Sequence: MAELNFKAIEEKWQKRWMEDRVFEPDRNAKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLFPMAWHITGAPIVGIAERIKNRDPKTIHIYRDVYKVPEEILWKFEDPKEIVKYFMKAARETFIRAGFSVDWSREFHTTSLFPPFSKFIEWQFWTLKDMGLVVKGAHRVRWDPVVGTPLGDHDIMEGEDVQILEYVIIKFILEENGEEIYMPAATLRPETVYGVTNMWLNPEAIYVKAKVRRGDREETWIISKEAAYKLSFQDREIEVIEEFKGERLIGKYVKNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKKETEILLKYDIDPRVVEEISYISLIKLEGYGEFPAVEEVEKLGVKSQKDEEKLEEATKNIYKAEYHKGVFKIEPYAGKPVQEVKDLIAKELQEKGIAEIMYEFAEKPVISRFGNQAVIKIIHDQWFIDYGNPEWKEKAREALANMTIYPESRRTQFEAVIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTISRHINKLREEGRLDPEKLDREFFDYLFREEFSEEREKELAEKTGIPAEIIHEMKEEFEYWYPLDWRCSAKDLIPNHLTFFIFNHVAIFRKGHWPRGIAVNGFGTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMGLAEHDSDFDWRRKEVGKLRKQVERFYELVSEFASYEAKEGVELKDIDRWMLHRLNKAIEGATKGLEEFRTRTAVQWAFYSVLNDLRWYLRRTEGRDDEAKRYVLRTLADVWVRLMAPFTPHISEELWEKLGGEGFVSLAKWPEPNPAWWNETIELEEEYVKNLIEDIKEIIRVAKIEDAKRAYIYTAPEWKWRVAEAVAEKRDFKAAMSELMKDPEMRKHGKEISKMIQRLIKDRAFEIKRIDEEKALREAKDFIEKELGLEIIINPEEDKGGKKKAAMPMKPAVFVE
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2640_GLOVI
Sequence: MLNLLWLVVVLMVIAALLGFGGVVSSLQSVAWFLIVAAVVLAVVGFVTGRRAL
What are the official names of this protein?
UPF0391 membrane protein gsr2640.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS8_PARDP
Sequence: MSQNQTTIAPQPGIMEISLYEGGASKVAGVENVVKLSSNENPFGPSDKAREAMIRAAHGLHRYPNTDHAGLRGAIGEVHGLDPDRIICGVGSDEIIHFLCQAYAGPGTEVLFTEHGFLMYRISAHAAGAIPVQVAERDRVTDIDALIAGATPRTRLIFVANPNNPTGTMVGLPELERLARAVPQAILVVDAAYAEYVGDYDGGAELATRLPNVFMTRTFSKIYGLGGLRVGWGYGPREIVDVLNRIRGPFNLSNVALEGAEAAMRDREHIARCQAENARMRAWLAEALAEKGVPSDTSCANFILARFADAETAGACDEYLKTQGLIVRRVAGYGLPHCLRITIGDEASCRRVAHVIGQYMAERAESR
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: PPNP_GEOMG
Sequence: MSEFINVTVVREANVFFNGGVVSRTVIFPDGTKKTLGIMQPGEYTFNTGAPEIMEILTGELDLKLPGSDLWDRIGGGESFEVPANSSFTMKVLSLTDYCCSFLG
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: TMPSC_HUMAN
Sequence: MRLGLLSVALLFVGSSHLYSDHYSPSGRHRLGPSPEPAASSQQAEAVRKRLRRRREGGAHAEDCGTAPLKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDASDPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQPICLPFDVFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHYISREMCNSERSYGGIIPNTSFCAGDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQKWLTEHFFHASTQGILTINILRGQILIALCFVILLATT
What are the official names of this protein?
Transmembrane protease serine 12.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: APC11_PONAB
Sequence: MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCILKWLHAQQVQQHCPMCRQEWKFKE
What is the function of this protein?
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.  May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).
What are the official names of this protein?
Anaphase-promoting complex subunit 11, APC11, Cyclosome subunit 11.
What is the protein family that this protein belongs to?
Belongs to the RING-box family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NALP_NEIMH
Sequence: MRTTPTFPTKTFKPTAMALAVATTLSACLGGGGGGTSAPDFNAGGTGIGSNSRATTAKSAAVSYAGIKNEMCKDRSMLCAGRDDVAVTDRDAKINRPPPPNLHTGDFPNPNDAYKNLINLKPAIEAGYTGRGVEVGIVDTGESVGSISFPELYGRKEHGYNENYKNYTAYMRKEAPEDGGGKDIEASFDDEAVIETEAKPTDIRHVKEIGHIDLVSHIIGGRSVDGRPAGGIAPDATLHIMNTNDGTKNEMMVAAIRNAWVKLGERGVRIVNNSFGTTSRAGTADLFQIANSEEQYRQALLDYSGGDKTDEGIRLMQQSDYGNLSYHIRNKNMLFIFSTGNDAQAQPNTYALLPFYEKDAQKGIITVAGVDRSGEKFKREMYGEPGTEPLEYGSNHCGITAMWCLSAPYEASVRFTRTNPIQIAGTSFSAPIVTGTAALLLQKYPWMSNDNLRTTLLTTAQDIGAVGVDSKFGWGLLDAGKAMNGPASFPFGDFTADTKGTSDIAYSFRNDISGTGGLIKKGGSQLQLHGNNTYTGKTIIEGGSLVLYGNNKSDMRVETKGALIYNGAASGGSLNSDGIVYLADTDQSGANETVHIKGSLQLDGKGTLYTRLGKLLKVDGTAIIGGKLYMSARGKGAGYLNSTGRRVPFLSAAKIGQDYSFFTNIETDGGLLASLDSVEKTAGSEGDTLSYYVRRGNAARTASAAAHSAPAGLKHAVEQGGSNLENLMVELDASESSATPETVETAAADRTDMPGIRPYGATFRAAAAVQHANAADGVRIFNSLAATVYADSTAAHADMQGRRLKAVSDGLDHNGTGLRVIAQTQQDGGTWEQGGVEGKMRGSTQTVGIAAKTGENTTAAATLGMGRSTWSENSANAKTDSISLFAGIRHDAGDIGYLKGLFSYGRYKNSISRSTGADEHAEGSVNGTLMQLGALGGVNVPFAATGDLTVEGGLRYDLLKQDAFAEKGSALGWSGNSLTEGTLVGLAGLKLSQPLSDKAVLFATAGVERDLNGRDYTVTGGFTGATAATGKTGARNMPHTRLVAGLGADVEFGNGWNGLARYSYAGSKQYGNHSGRVGVGYRF
What is the function of this protein?
Cleaves human (host) complement factor C3, generating a shorter alpha chain and a longer beta chain than normal.  Does not act on mouse or rabbit C3.  Cleavage causes C3b degradation by human CFI and CFH, decreases deposition of C3b on the bacteria surface and probably facilitates complement escape.
What are the official names of this protein?
Neisserial autotransporter lipoprotein NalP, Autotransporter NalP, NalP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
Protein: TTLL5_MOUSE
Sequence: MPVVMARDLEETASSSEDEDLANQEDHPCIMWTGGCRRIPVLVFHAEAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVKPVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGSKNIRNQFMHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGKDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDNTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRTSNRSIYPSFESSRRNPFQKPQRTRPLSASDAEMKNLVASAREKVPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRGNPRRSLLTGRARVSTEGAPELKVESMNSKAKLHAALYERKLLSLEVRKRRRRSGRLRAMRPKYPVIAQPAEMNIKTETESEEEEEVGLDNDDEEQEASQEESAGSLGENQAKYTPSLTVIVENSPRDNAMKVAEWTNKGEPCCKIEAQEPESKFNLMQILQDNGNLSKVQARLAFSAYLQHVQIRLTKDSGGQTLSPSWAAKEDEQMELVVRFLKRASSNLQHSLRMVLPSRRLALLERRRILAHQLGDFIGVYNKETEQMAEKKSKKKLEEEEEDGVNAESFQEFIRQASEAELEEVLTFYTQKNKSASVFLGTHSKSSKNSSSYSDSGAKGDHPETIQEVKIKQPKQQQATEIHADKLSRFTTSSGKEAKLVYTNCSSFCSPAAVLLQRLPSSHLSSVITTSALSAGPGHHASLSQIPPAVPSLPHQPALLLSPVPDNAPPSIHSGTQNVSPAGLPRCRSGSYTIGPFSSFQSAAHIYSQKLSRPSSAKAAGSCHPHKHHSGIAKTQKEGEDVSLNRRYNQSLVTAELQRLAEKQAARQYSPASHISLLTQQVTNLNLASSVINRSSASTPPTLRPVISPSGPTWSIQPDLHASETHSSPPGSRSLQTGGFAWEGEVENNAYSKTTGVVPQHKYHPTAGSYQLHFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSSLWTMNNGPGCRISSATTGGQKPNTLPQKVVAPPNSSTLVSKPASNHKQVLRKPASQRASKGSSAEGQLNGLQSSLNPAAFMPITNSTGSLEAPQVIFARSKPLPTQSGALATVIGQRKSKSVKSGTI
What is the function of this protein?
Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:17499049).  Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step (PubMed:17499049).  Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049).  Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules (By similarity).  Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity).
What are the official names of this protein?
Tubulin polyglutamylase TTLL5, Tubulin--tyrosine ligase-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the tubulin--tyrosine ligase family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm. Note=In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid (By similarity). Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium.
Protein: THAP1_THAPI
Sequence: MKLLILALTCAAAVWARPGETYSDKYDTIDVNEVLQSERLLKGYVECLLDKGRCTPDGKELKDTLPDALEHECSKCTEKQKSGADTVIRHLVNKRPELWKELAVKYDPENIYQERYKDRLESVKEH
What are the official names of this protein?
Allergen Tha p 1.
What is the protein family that this protein belongs to?
Belongs to the insect A10/OS-D protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: ASTB_LEGPC
Sequence: MNVYELNMDGLVGQTHHYAGLSSGNIASTNNALSISNPQAAARQGLEKMRQLYNMGLKQGLLPPHQRPNLNLLYQLGFKGTPSEQINKAYKTAPELLSACYSASSMWTANAATVSASVDTEDNKVHFTAANLISNLHRHQEADFSKKLLEFIFSNSDYFNHHPLLPKSMGTSDEGAANHNRLCQSHAHSGINLFVYGKKVLGNHQFEQSPIKYPARQTKEASEAIARNHLLNPERVIFACQNPLAIDQGVFHNDVISVANEHVFLVHEEAFYNQAYVLDQLREKADFPLVIIQISKEQISVSEAVDTYLFNSQLITLPDQKNMILIAPAECQANLKVKTCIDGLVADPQNPINSVYYLDLKQSMRNGGGPACLRLRVPLNDYELKAMHQGILIDNDLLDILDKWVLKYYRTELKIPDLADPQLLYECLDALDELTQILKLGSIYPFQS
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: URE3_CORGB
Sequence: MHITPREQEKLMIVVAADLARRRKDRGLKLNHPEAVALITYELIEGARDGRTVADLMSWGSTILTRDDVLEGIPEMIPDIQVEATFDDGTKLVTVHNPIR
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCAL_STAES
Sequence: MKSVGLITEYNPFHNGHLFHATLSKQRSETNVTIAIMSGNFVMRGEPAIYHKFKRTEMALSAVDLVVELPLIGSLSSSDTFAEIAIKTAQYLDIDIISFGSESASLKDLQYLATQMIDYEKHPDFKEKLKQGKSYPRILSELTHNDTLLQSPNNILGISYLKAMQQFAPHMSALTIKREGSLHHQKVIDHHHFASGTSIRRSLMNDNVDWKNVVPNQIQSLYCKPHTTVEDTFPFIKHQLITQPKESLHSIYTINEGFENRLQTMIHRSDSFESLLSNLKTKRYTQTYIQRVLMNVLLNITKDDVNKEINAVRVLGMSEKGRSYLKYLKANYPNRHYITNVNQKTAHYFKNEIKATHVYNLLSNQSQTDFNTPLVRI
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_BRADU
Sequence: MDASLPAHMRPERSFQGFILALQRFWAEQGCVILQPYDMEMGAGTFHPATTLRALGPKPWNAAYVQPSRRPKDGRYGENPNRMQHYYQFQVIMKPSPPNLQELYLKSLAAIGIDSAVHDIRFVEDDWESPTLGAWGLGWECWCDGMEVSQFTYFQQVAGFECAPVAGELTYGLERLAMYVQGVDRVYDLNFNGRDGDAKVTYGDVFLQAEREYSKHNFEVADTAMLFEQFKMAEAACRKYLDAGWREGNRKEHLMALPAYDQCIKASHVFNLLDARGVISVTERQSYILRVRELAKACGEAWIHTEAGGAA
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIHB_ECOLU
Sequence: MEKRKIILDCDPGHDDAIAIMMAAKHPVIDLLGITIVAGNQTLDKTLINGLNVCQKLEINVPVYAGMPQPIMRQQIVADNIHGETGLDGPVFGPLTRQAESTHAVKYIIDTLMASDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGNFTPSAEFNIFADPEAARVVFTSGVPLVMMGLDLTNQTVCTPDVIARMERVGGPAGELFSDIMNFTLKTQFENYGLAGGPVHDATCIGYLINPDGIKTQEMYVEVDVNSGPCYGRTVCDELGVLGKPANTKVGITIDTDWFWGLVEECVRGYIKTH
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.  Has a clear preference for cytidine over uridine.  Strictly specific for ribonucleosides.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihB, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihB subfamily.
Protein: NRFH_WOLSU
Sequence: MNKSKFLVYSSLVVFAIALGLFVYLVNASKALSYLSSDPKACINCHVMNPQYATWQHSSHAERASCVECHLPTGNMVQKYISKARDGWNHSVAFTLGTYDHSMKISEDGARRVQENCISCHASLSSTLLENADRNHQFNDPKGASERLCWECHKSVPHGKVRSLTATPDNLGVREVK
What is the function of this protein?
Subunit of the nitrite reductase complex that mediates electron transfer from quinol to the catalytic subunit.
What are the official names of this protein?
Cytochrome c-type protein NrfH.
What is the protein family that this protein belongs to?
Belongs to the NapC/NirT/NrfH family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: RL28_BORAP
Sequence: MARKCEITGKKTMFGNNVPRKGLAKKKGGARQHIGVKTKRTFKVNLINKKFFIPDLGRSINIKVSANALRSISKIGLDAFLKKNCKKIENFL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: CD81_CHLAE
Sequence: MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLELGDKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLAALTTSVLKNNLCPSGSNIISNLLKKDCHQKIDELFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY
What is the function of this protein?
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling.  Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells.  Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production.  In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype.  Present in MHC class II compartments, may also play a role in antigen presentation (By similarity).  Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes.  Positively regulates sperm-egg fusion and may be involved in acrosome reaction.  In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity).  In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity).  Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity).  May regulate the compartmentalization of enzymatic activities.  In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (By similarity).  Also involved in cell adhesion and motility.  Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity).
What are the official names of this protein?
CD81 antigen.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Protein: PP11_YEAST
Sequence: MVSRGPDEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDNVEAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVPDDYIRESTANHNNQRAGYFL
What is the function of this protein?
Involved in the dephosphorylation of the large subunit of RNA polymerase II.  Is required in late G1 for normal G1 cyclin expression, bud initiation and expression of certain genes that are periodically expressed during late G1.  Associates with the SAP proteins in a cell cycle-dependent manner.
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1-1.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_RICFE
Sequence: MKTYSAKPSEIEKKWWVIDAKNIVLGRLASRVANMLRGKHKPSFTPHLDCGDNIIIINAEHVKLTGKKANPKDGKIYYRHTGFPGGLKDTTAGKILSSKHPERVIKMAVKRMITRNTLGAKQMSNLYVYANGDHPHMAQQPTVYDFASQNPKNKK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: NANK_ECO57
Sequence: MTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQAHAQRVAIASTGIIRDGSLLALNPHNLGGLLHFPLVKTLGQLTDLPTIAINDAQAAAWAEYQALEGDITDMVFITVSTGVGGGVVSGGKLLTGPGGLAGHIGHTLADPHGPVCGCGRTGCVEAIASGRGIAAAAQGELAGADAKTIFMRAGQGDEQAQQLIHRSAHVLARLIADIKATTDCQCVVVGGSVGLAEGYLALVETYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEKL
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.
Protein: XERD_STAAN
Sequence: METIIEEYLRFIQIEKGLSSNTIGAYRRDLKKYQDYMTEHHISHIDFIDRQLIQECLGHLIDQGQSAKSIARFISTIRSFHQFAIREKYAAKDPTVLLDSPKYDKKLPDVLNVDEVLALLETPDLNKINGYRDRTMLELLYATGMRVSELIHLELENVNLIMGFVRVFGKGDKERIVPLGDAVIEYLTTYIETIRPQLLKKTVTEVLFLNMHGKPLSRQAIWKMIKQNGVKANIKKTLTPHTLRHSFATHLLENGADLRAVQEMLGHSDISTTQLYTHVSKSQIRKMYNQFHPRA
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerD.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.