PharMolix/UniProtQA huggingface dataset:
Protein: EDC1_CANGA
Sequence: MSNDTMYFNSSRRLPTHSRNNSPIVAAKNNSSTRIPALNNKKPSKKTEKDIEQLLSPQQLPNGQRPDFGHGPRGGKQTNGAKTKNKKKQDKELQETKDSYDNLTKNLKNLLINPEKTEKTVVETLIKSNSNSATATPQKAPNTTQGITNSHGLSQNFSSPLSTPMILPHNLPMNPLGNPNFPANNHYLPYNPQQLQQQQQQQNRLPVGPGPMNFDNFRPGIAPVAPPQPPPGYPPGPNGPPPGMPQQLNFNGQPMYYNQPPMPVPNSAFPINQSIGASPTLPRIIPPNPMNYINPALSTPPVVKNPTSNGPVTNTKPTNKSKRNSGRKSNTFAGASFATDVPNESNLPKPSFT
What is the function of this protein?
mRNA-binding protein which stimulates mRNA decapping.
What are the official names of this protein?
Enhancer of mRNA-decapping protein 1.
What is the protein family that this protein belongs to?
Belongs to the EDC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S22AE_HUMAN
Sequence: MAGEENFKEELRSQDASRNLNQHEVAGHPHSWSLEMLLRRLRAVHTKQDDKFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKETSSDDV
What is the function of this protein?
Riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa midpiece, which is required for male fertility (By similarity).  SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (By similarity).  Required for sperm motility and normal sperm flagellar structure (By similarity).
What are the official names of this protein?
Solute carrier family 22 member 14, Organic cation transporter-like 4, ORCTL-4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Localizes to the principle piece of the sperm tail.
Protein: PHL21_ARATH
Sequence: MTSNQRMLFYSCIAKGTVILAEFASKEEPGIEDLALRCIENVPPHHSMISHTVHKRTYALIIDGLFSYFAILDEVVAKSESVWLFNRLKSATESLMEDGSTADSLDNPTQHCLQSKLDPVFAEIAAIGGNHNKDLELEFGSPRSIAREIKSNNQSLDSSKGRKGGALMPLLGKPLRVLKNKKRLQTEAKSEGHWNEKKMDLGGGGKGVRNGLIHDHHHRQKAKQIWRKHVWIVLMFDLCICLVLFGIWLWICQGFQCIDG
What is the function of this protein?
Non-SNARE longin protein involved in membrane-trafficking machinery.
What are the official names of this protein?
Phytolongin Phyl2.1.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein.
Protein: Y171_PSET1
Sequence: MNDKLSYYKQQVGSFLRQQPGWWMQYINRCIDDQITVNAGYLAYVTLLSLVPLIAVGVAIFSAFPGFESTRLAIESFLFTNFVPTSSDVIKEHISSFAGNANQMTAVGIGFLAAIALLLIRNVDATLNRIWRIKKKRPMMISFAVYWMVLSLGPVFLGGSIAVTSYIVSLVSFADQGIPGFSGFLLKLLPYGISMVGFIMLYTLVPNTRVSFKAAIPGALFAAMLFELTKKGFALYISHFPSYEVIYGAVATIPILFVWIYLSWIVVLLGAELTACISPENIEDTPEIELDEQENTKDTL
What are the official names of this protein?
UPF0761 membrane protein PSHAa0171.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Z_BCNVU
Sequence: MGLRYSREVKQRYGEKELEGRIPITLDMPQTLYGRYNCKSCWFANKGLIKCSNHYLCLKCLTAMLSRSDYCGICGGILPKKLVFETTPSAPPYTP
What is the function of this protein?
Plays a crucial role in virion assembly and budding.  Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L.  Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP.  Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway.  The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z.  Also selectively represses protein production by associating with host eIF4E.
What are the official names of this protein?
RING finger protein Z, Protein Z, Zinc-binding protein.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae Z protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm, host perinuclear region. Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Mainly perinuclear. During budding, associates at the inner side of the plasma membrane of infected cells.
Protein: GPSB_STRSV
Sequence: MASIIFTAKDIFDQDFKREVRGYSKSEVDEFLDDIIKDYETYAALVKELREENRRLKEELAAKPVEKAPVQPTQPVQSTQATQSTVESFSQMTSATNFDILKRLNRLEKEVFGKQILDRE
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: CCHL_YEAST
Sequence: MGWFWADQKTTGKDIGGAAVSSMSGCPVMHESSSSSPPSSECPVMQGDNDRINPLNNMPELAASKQPGQKMDLPVDRTISSIPKSPDSNEFWEYPSPQQMYNAMVRKGKIGGSGEVAEDAVESMVQVHNFLNEGCWQEVLEWEKPHTDESHVQPKLLKFMGKPGVLSPRARWMHLCGLLFPSHFSQELPFDRHDWIVLRGERKAEQQPPTFKEVRYVLDFYGGPDDENGMPTFHVDVRPALDSLDNAKDRMTRFLDRMISGPSSSSSAP
What is the function of this protein?
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
What are the official names of this protein?
Holocytochrome-c synthase, Cytochrome c heme lyase, CCHL.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-type heme lyase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Mitochondrion intermembrane space.
Protein: 14332_ARATH
Sequence: MASGREEFVYMAKLAEQAERYEEMVEFMEKVSAAVDGDELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNDDHVTAIREYRSKIETELSGICDGILKLLDSRLIPAAASGDSKVFYLKMKGDYHRYLAEFKTGQERKDAAEHTLAAYKSAQDIANAELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQDDAADEIKEAAAPKPTEEQQ
What is the function of this protein?
Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.
What are the official names of this protein?
14-3-3-like protein GF14 omega, General regulatory factor 2.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Translocates from the cytosol to the nucleus when phosphorylated.
Protein: YDHX_ECOLI
Sequence: MSFTRRKFVLGMGTVIFFTGSASSLLANTRQEKEVRYAMIHDESRCNGCNICARACRKTNHVPAQGSRLSIAHIPVTDNDNETQYHFFRQSCQHCEDAPCIDVCPTGASWRDEQGIVRVEKSQCIGCSYCIGACPYQVRYLNPVTKVADKCDFCAESRLAKGFPPICVSACPEHALIFGREDSPEIQAWLQQNKYYQYQLPGAGKPHLYRRFGQHLIKKENV
What are the official names of this protein?
Uncharacterized ferredoxin-like protein YdhX.
Protein: IMDH_MYCTU
Sequence: MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTEQHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:20491506, PubMed:21081761).  Does not catalyze the reverse reaction, i. e.  the conversion of XMP to IMP (PubMed:21081761).  Appears to be essential for the optimal growth of M. tuberculosis (PubMed:12657046).
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH, IMPDH2.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: RS17_CLOAB
Sequence: MERGNRKTRIGRVVSDKMDKTIVVAVETKVRHPLYGKTVNKTTKFKAHDEKNEAKLNDRVQIMETRPLSKDKRWRLVEIVEKAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PANC_FRATM
Sequence: MIIADNIKQFHSIRNSLIKQQKIGFVPTMGALHNGHISLIKKAKSENDVVIVSIFVNPTQFNNPNDYQTYPNQLQQDIQILASLDVDVLFNPSEKDIYPDGNLLRIEPKLEIANILEGKSRPGHFSGMLTVILKLLQITKPNNLYLGEKDYQQVMLIKQLVKDFFINTKIIVCPTQRQPSGLPLSSRNKNLTSTDIEIANKIYEILRQDNFSNLEELTNKINSTGAKLQYIQKLNNRIFLAFYIGKVRLIDNFLKETGPSC
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_LEPBJ
Sequence: MQRGKKYKALKEKVDSTKFFNIDQAVELAKSTSYTKFDGTVEIATKVDYKSLQNIRGTISLPHGNGKKVRVLVFCKGDKQNDAKAAGAEFVGDMDLIEKVAGGWTDFDACVATPDMMKDVGKLGPILGRKGLMPKPKAGTVTTDVAKAVNELKSGRVEYRPDKGGVVHLGVGKVSFDNAKLVENIRTVVQTLMRDKPSDAKGDYLKTFSVSPTMGVGVKVDVKELVNTSI
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: RS12_FRATF
Sequence: MATINQLVNNPRKRSVVKSKVPALKACPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSRFEVTSYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTSGVNNRKHGRSKYGTKRPKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: DRMH2_ARATH
Sequence: MGVLENLWDDVVAGPRPEAGGRGHLRRISTSLTSLNNTTEGMSVAGSVSLPASPATPVTPGSGRKVDVWRSVFHPASNVTTREIGANVFDKPSHPNSPTVYDWMYSNETRSKHR
What are the official names of this protein?
Dormancy-associated protein homolog 2, DRM1 homolog 2, Dormancy/auxin associated family protein.
What is the protein family that this protein belongs to?
Belongs to the DRM1/ARP family.
Protein: RDRP_BPGA
Sequence: MFRFREIEKTLCMDRTRDCAVRFHVYLQSLDLGSSDPLSPDFDGLAYLRDECLTKHPSLGDSNSDARRKELAYAKLMDSDQRCKIQNSNGYDYSHIESGVLSGILKTAQALVANLLTGFESHFLNDCSFSNGASQGFKLRDAAPFKKIAGQATVTAPAYDIAVAAVKTCAPWYAYMQETYGDETKWFRRVYGNGLFSVPKNNKIDRAACKEPDMNMYLQKGAGSFIRKRLRSVGIDLNDQTRNQELARLGSIDGSLATIDLSSASDSISDRLVWDLLPPHVYSYLARIRTSFTMIDGRLHKWGLFSTMGNGFTFELESMIFWALSKSIMLSMGVTGSLGIYGDDIIVPVECRPTLLKVLSAVNFLPNEEKTFTTGYFRESCGAHFFKDADMKPFYCKRPMETLPDVMLLCNRIRGWQTVGGMSDPRLFPIWKEFADMIPPKFKGGCNLDRDTYLVSPDKPGVSLVRIAKVRSGFNHAFPYGHENGRYVHWLHMGSGEVLETISSARYRCKPNSEWRTQIPLFPQELEACVLS
What is the function of this protein?
This is the catalytic subunit of the viral RNA-dependent RNA polymerase complex.  This complex is involved in viral RNA replication that produces (+)-stranded genomes via a complementary, (-)-stranded intermediate.
What are the official names of this protein?
RNA-directed RNA polymerase beta chain, RNA replicase beta chain.
Protein: RP35_VAR67
Sequence: MRHPREENSIVVELEPSLATFIKQGFNNLVKWPLLNIGIVLSNTSTAINEEWLTVVEHIPTMKIFYKHIHKILTREMGFLVYLKRSQSERDNYITLYDFDYYIIDKDTNSVTMVDKPTELKETLLHVFQEYRLKSSQTIELIAFSSGTVINEDIVSKLTFLDVEVFNREYNNVKTIMNPDFVSRSPFIVISPMGKLTFFVEVYSWFDFKSCFKDIIDFLEGALIANIHNHMIKVGDCDETVSSYNPESGILFVNDLMTMNIVNFFGCNSRLESYHRFDITKVDVELFIKALSDACKKILLASNRL
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of D6 and A7, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase 35 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 35 kDa subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle (By similarity).
Protein: CDS2_HUMAN
Sequence: MTELRQRVAHEPVAPPEDKESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLIGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFLTLRPDQQLHIFNTLRSHLIDKGMLTSTTEDE
What is the function of this protein?
Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833).  Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833).  Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309).
What are the official names of this protein?
Phosphatidate cytidylyltransferase 2, CDP-DAG synthase 2, CDP-DG synthase 2, CDP-diacylglycerol synthase 2, CDS 2, CDP-diglyceride pyrophosphorylase 2, CDP-diglyceride synthase 2, CTP:phosphatidate cytidylyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYR_RHOBA
Sequence: MHLPNVLQARFVQALEPLTDSPSDYAGMIRPAADPKFGDYQSNAAMPLAKRVGKTSRDVAAELVQNLNVTDLFEEPEVAGPGFINLRLKDSVLFDSIQQMLLDERVGVSKTTDPKKVIVDFSSPNVAKPMHVGHIRSTVIGDCLARTLRFYGEDVVTDNHLGDWGTQFGIIIYGYRNFGDPAKVAANPVPELSALYRLTNQLIEYQKAKQSLATMADKLATAKSDAKTAKEVSDQSESDENLKPKDKKKLRKNAEAATRRVASIEADMKSLKAKIDAVDSDTELSKLASEHSDVDVAVLRETAKLHEGDPENLALWKEFLPHCQDEINRIYDRLNVQFDHTLGESFYHDRLAGVVDHLTTLGLTTKSDGAICVFLEGFDSPMIIQKRDGAFLYATTDLATLQYRRDEFQPDEILYVVDSRQGEHFKKFFAMAEPLGMAEVQLVHVNFGTVLGPDGRPMKTRSGSLIGLESLLNDAVSRAKEVVCNPDRLATMDPPMGGEEQQQIAEIVGIGAIKYADLSHHRTSDYKFDVDKMVALEGNTATYVQYSYARTQSILRRASDGEGLPAFEQAIEQAAATQPMTFTHPNERSLALMLMRFEEAIEQVRLNYAPNALCDYLFETAKTYSSFNESCRVLGNDDPAVMQTRLALVVLTGRVLKKGLSLLGIDVAERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOP53_MOUSE
Sequence: MAAGGNRDGEKRGSRSQADSGFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAEEPLGLEVDQFLEDVRLQERTTGGLLAEAPNEKLFFVDTGFKRKEPRKKRTLVQKKSQRLQKPLRVDLALENHSKIPAPKDILAHQVPNAKKLRRKEELWEKLAKQGELPRDVRKAQARLLSPPTPKAKPGPQDIIERPFYDLWNPDNPLDTPLIGQDAFFLEQTKKKGVRRPQRLHIKPSQVPAVEVIPAGASYNPTFEDHQALLREAHEVELQREKEAEKLERQLALPTSEQAATQESVFREMCEGLLEESDGEDEHEAGRAGQPEAGDGTTEISPTGAAGPEKRMEKKTEQQRRREKAARKLRVQQAALRAARLQHQELFRLRGIKAQVARRLAELARRREQRRIRRLAEADKPRRLGRLKYQAPDIDVQLSSELSGSLRTLKPEGHILRDRFKSFQKRNMIEPRERAKFKRKYKVKLVEKRAYREIQL
What is the function of this protein?
Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis.  In ribosome biogenesis, may also play a role in rRNA transcription (By similarity).  Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions.  DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:21804542).  It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation.  Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway.  May also inhibit cell proliferation and increase apoptosis through its interaction with NF2.  May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation.  Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex.  May also regulate cellular aerobic respiration.  In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (By similarity).
What are the official names of this protein?
Ribosome biogenesis protein NOP53, Glioma tumor suppressor candidate region gene 2 protein, PreS1-binding protein.
What is the protein family that this protein belongs to?
Belongs to the NOP53 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Note=In the nucleolus may be more specifically localized to the fibrillar center. Mainly nucleolar it relocalizes to the nucleoplasm under specific conditions including ribosomal stress enabling it to interact and regulate nucleoplasmic proteins like p53/TP53. Also detected in the cytosol.
Protein: RS18_POLNS
Sequence: MAFGKKPAQNPLFKRKRYCRFTVAGVEQIDYKDVDTLKGFIGENAKITPARLTGTKAKYQRQLDTAIKRARYLALLPFSDQHKK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RRP3_CYACA
Sequence: MKQYKIKVLWLRNNIAIAVDRLIGDSLFPMTYYYFWPRTDAWEQLKIELDSQPGLFAKDKVVILNQVTRIIDYWQENKKSVFPNLSELQSHFPDLICSGCY
What is the function of this protein?
Probably a ribosomal protein or a ribosome-associated protein.
What are the official names of this protein?
Probable 30S ribosomal protein 3, chloroplastic, PSRP-3.
What is the protein family that this protein belongs to?
Belongs to the chloroplast-specific ribosomal protein cS23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CYSD_BUCA5
Sequence: MFKKNTTHLRQLESESIYIMREVMSDFQNPVMLYSIGKDSSVMLHLAKKSFYPGTIPFPLLHIDTGWKFKEMYIFRDHIASTSNIELIVHSHSKGKLLGLNPFENGGSKYTDIMKTEGLKEAINKYNFDAAFGGARRDEEKSRSKERIYSFRDSLHQWDPKKQRPELWWNYNGQINKGENIRVFPLSNWTELDIWQYIFLEKIEIVPLYFAAKRPVLERNGVLTVIDDSRMKIKSNEVIKEKMVRFRTLGCWPLTNAIESEARNVEDIIKETLIVKTSERTGRAIDYDQKSSMEFKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: YAAA_ECOUT
Sequence: MLILISPAKTLDYQSPLTTTRYTLPELLDNAQQLIHEARKLTPPQISSLMRISDKLAGINAARFHDWQPNFTPENARQAILAFKGDVYTGLQAETFSEDDFDFAQQHLRMISGLYGVLRPLDLMQPYRLEMGIRLENARGKDLYQFWGDIITNKLNEALAAQGDNVVINLASDEYFKSVKPKKLNAEIIKPVFLDEKNGKFKIISFYAKKARGLMSRFIIENRLTKPEQLTGFNSEGYFFDEASSSNGELVFKRYEQR
What are the official names of this protein?
UPF0246 protein YaaA.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: GLMM_CLOBL
Sequence: MGRMFGTDGVRGVANKELTADLAYKLGKAGAFILTEGTHRPKILVGMDTRISGDMLESALVAGILSVGAEAICVGVIPTPAIAYLTRKYNADAGVVISASHNPVEYNGIKFFNKNGYKLSDELEDSIQALIRDDFKDVPVLTGENIGRKIEEDGEAIRDYIDFAKSTIKGDLKGLKVALDCANGASYITSVEAFKELEAEVHVINNKPDGININRNSGSTHPEDLMEYVVKNNCHMGLAFDGDADRCLAIDEKGNLINGDFILAICGKELKKQGRLKKNTIVVTVMSNLGLDIAMKKEEINTIKTKVGDRYVLEEMLKNDYAIGGEQSGHIIFSDYNTTGDGLVTALQLAHIVKESGKTFSELCSIMKELPQVLVNAKVPNDQKDIYLKDEEIKSEIDTITKNLDGSGRVLIRPSGTEPLVRVMLEGENQKEIDKLAHGLAKLIENKVK
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: Y1471_METMP
Sequence: MEDEIKSFEKDRNLIIEDSKNSKNNIVDVQKLIEALKDEKNAKNIVVDFTEYNPLHNGHKYCMDFGKSEGLFISVIPGPLERSGRGIPYLVNRHIRAEMALLAGADLVVEGPPMGIMGSGQYMQCLIKIFSALNGDIIPRGYIEEETMERVINSINNGNHIKIKPYNISCIETREKLGEKLEIDNYVIASMSYTIYKLKENFPKWNPKFKFIERIEGISGTKIREGVFNNNFESIKHMLPITTIDVFKNFGDNLSEIILKRNEEMVLDTVNNFDLNKYLPENISEKLNEKEYYESIEEIKEYIPRGFSKNNIERTISKLEARIEKETISKYIENYPANLRILNGINNHE
What are the official names of this protein?
Uncharacterized protein MMP1471.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.