PharMolix/UniProtQA huggingface dataset:
Protein: GPPA_PROMH
Sequence: MLKSSSLYAAIDLGSNSFHMLVVREIAGSIQVLSRVKRKVRLAAGLNKENELSEQAMERGWQCLRLFSEYLRDIPAEQIRVVATATLRIAKNADIFVAKASEILGNTVHVISGEEEARLIYRGVAHTTGGAEQRLVVDIGGGSTELVTGTGAKTTQLMSLSMGCVTWLERYFSDRSLTEENFAQAQQAAKAILAPVAEKLIQQGWQVCVGASGTVQALQEIMIAQGMDELITLPKLERLKQKAIECGKLEELEIEGLTFERALVFPSGLAILIAIFETLHIENMILAGGALREGLVYGMLHLPIEQDIRQRTLRNIQRRFQIDIEQAHRVQQLAEHFFIQVSKSWQLDNRCRELLSSACALHEIGLSVDFRQAPSHASYLVSHLDLPGYTPAQRRLIASFLRNQKGIIDLAPLNQQNALPINQAYRLVRLLRLAIIFASRRRDDTLPALRLRTEDEKLIITLPHQWIAEHPLRAENLHEEIQLQSYVHWPLMLEEQNNSRIG
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: SECA_EHRRW
Sequence: MLNIAQRIFGSTNTRLVKSLYKIVNQINAIEHEFQILSDESLKNKTIEFKEQLNNGKTLDDILVPAFAVVREASKRILNMRHFDVQLIGGIVLHKGMISEMKTGEGKTLVATLAAYLNALEGKGVHVVTVNDYLAKRDADWMGELYNSLGITVGCILSDTNDLDRKKAYNCDIVYSTNNNLGFDYLRDNMKFSRNEMVQRGFNYAIVDEVDLILIDEARTPLIISGQVDQDIKMYNKIDKLIYELSEEDYELEEKHRNIFLTECGITKIENLLIQHKLISSNTSLYDIDNMIIMHYITQALRAHKIFSLDKDYIIKDGNIIIIDEFTGRMMDGRRYSDGLHQAIEAKEKLNVNNENQTLASITFQNYFRMYKKLSGMTGTAETESEELLGIYNLQVVQIPTNTPVQRIDLNDDIYCTEEEKFDAIIKFISECHKKLQPVLVGTISIEKSEILSKLLTKNKLKHSVLNARYHEQEAYIIAQAGIPGTITIATNMAGRGTDIQLGGNLKMLAKTTLANILDKEIISIKYKQLVEKVNKDKEIAIQAGGLCVIGTERHESRRIDNQLRGRSGRQGDPGLSKFFLSLEDDLLRIFGSDKIKGMLKKLGMKKGEAIQHTWISRAIEKAQHKVELRNYDIRKSLLKFDNVINEQRKVVFDQRNRILDNDSYNISLIYRDINSDIVNNIIHDKYYNLDDETYKLISSEITRIYSITLDYNTISELESKNKLIEHINNITDEFFNKKIAEFTSKEKDLWDNLTKKVMIMSLDYLWREHLAALDSLKCGINLRSIAQKDPLNEFKSEAFSMLESMMSNFYELIIQRLAHLKSDNIFHSYSKELNNLQSSQDINSIKISRNEKCPCGSGKKYKHCHGENI
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: SYM_SALA4
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSDENRELSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSADQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTTSFDEYWKKDSDAELYHFIGKDIVYFHSLFWPAMLEGSHFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLKHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLAAELADPQLYKTFTDAAAVIGEAWESREFGKAIREIMALADIANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPTLSERVEAFLNSELNWDAIEQPLLGHKVNTFKALYNRIDMKQVEALVEASKEEVKAAAAPVTGPLADFPIQETITFDDFAKIDLRVALIENAEFVDGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRQTVMVANLAPRKMRFGVSEGMVMAAGPGGKDIFLLSPDDGAKPGQQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4584_MYCA9
Sequence: MTNIEDKDWSRSEGDSWDIVSSVGFTALGVAAARAVENREADPLVRDPYAEHFVRAAGEPHLIGLLDSSEPKPPNPGTAPRHIGLRSKFFDEFFINATNSGCKQAVILAAGLDVRAHRLPWPAGTKVFELDQPQVLEFKDRVLAEHDATPTSDRREIAVDLRDDWPAALLAAGFDPEVPTAWSAEGLIIYLPSAAQDLLFERVVALSAPGSQVAVEATRGRPDIAKWGEMQKKYADEGHPMSKVDITTLFYDEERADVAEWLAARGWKVQGSHALELAAAYGVEIPELPEDVVEVVKQGNYVTAVLPS
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MAB_4584c.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: PGA62_CANAL
Sequence: MQFSSAVVLSAVAGSALAAYSNSTVTDIQTTVVTITSCEENKCHETEVTTGVTTVTEVDTTYTTYCPLSTTEAPAPSTATDVSTTVVTITSCEEDKCHETAVTTGVTTVTEGTTIYTTYCPLPSTEAPGPAPSTAEESKPAESSPVPTTAAESSPAKTTAAESSPAQETTPKTVAAESSSAETTAPAVSTAEAGAAANAVPVAAGLLALAALF
What is the function of this protein?
Cell wall protein necessary for cell wall integrity.  Plays only a minor role in hyphal morphogenesis and is not critical to biofilm formation.
What are the official names of this protein?
Cell wall protein PGA62, Flocculation protein 1, GPI-anchored protein 62.
What is the protein family that this protein belongs to?
Belongs to the HWP1 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Protein: KDPC_PSEE4
Sequence: MTAYVRPALSLILLMTVVTGALYPLAVTGIAQVAFPKQANGSLVRDDRGEVRGSALIAQEFKGDGWFQSRPSAGAYATVASSASNLSPSNPALAERVKTDAAAQYQAQQGPVPQALLTTSGSGLDPHLPPEAIAYQLPRVAAARQVSEERLQVLVNDATLRPLIGPPVVNVLALNQALERLAPLAAR
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NAGB_PORG3
Sequence: MRLIIEPDYDKLSTWAADYVIERIHKAAPTAEKPFVLGLPTGSSPIGMYRELVKACKEGCISFRHVITFNMDEYVGLATEHPESYHSFMHRHLFDHIDILPQNIHILNGNAPDLTAECDAYERAIEAAGGIDLFIGGIGPDGHIAFNEPGSSLTSRTRIKTLTTDTVLANSRFFDNDTNQVPKRALTVGVGTIMDAREVMILVNGHTKARALREAVEGAVSQMWTITALQLHRQSIIVCDEAACVELKVGTYNYFKDIERNNL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: NDHJ_NICTO
Sequence: MQGRLSAWLVKHGLIHRSLGFDYQGIETLQIKPEDWHSIAVIFYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIEDGVDQPEEVCIKVFASRRNPRIPSVFWVWKSVDFQERESYDMLGISYDNHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAH
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: NLTP_BETVU
Sequence: MASSAFVKFTCALVMCMMVAAPLAEAITCGLVASKLAPCIGYLQGAPGPSAACCGGIKSLNSAAASPADRKTACTCLKSAATSIKGINYGKAASLPRQCGVSVPYAISPNTNCNAIH
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.  Also has fungicide activity.
What are the official names of this protein?
Non-specific lipid-transfer protein, LTP.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: CHE13_CAEEL
Sequence: MEEEHEEESHLSQSDTVGSAIVEDGPGKEYEIYIKNEELVDKLKLLNYEDGFLKLGVVYKPILKHYFVKSKNVGEQFFLFTSLAAWLIKKSGDESYNMPQEFDDPNSTLANIMAAAKNKGIATDFTAAKLKSGAGENVIFILNSLADASLVHVGFQWQKMIPPKEEDEDTAVDEQDEDDDNDDIVEEPMNFLDDDDDDNVIEIDLKAQGLATESKNPLQSVLQSNTDAITWKQEVERVAPQLKITLKQDAKDWRLHLEQMNSMHKNVEQKVGNVGPYLDNMSKDIAKALERIASREKSLNSQLASMMSKFRRATDTRAELREKYKAASVGVSSRTETLDRISDDIEQLKQQIEEQGAKSSDGAPLVKIKQAVSKLEEELQTMNVQIGVFEQSILNTYLRDHFNFSANLLNIM
What is the function of this protein?
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:12651157, PubMed:28479320).  May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320).  Required for the formation of chemosensory cilia that detect chemosensory cues (PubMed:12651157).
What are the official names of this protein?
Intraflagellar transport protein che-13, Chemotaxis abnormal protein 13.
What is the protein family that this protein belongs to?
Belongs to the IFT57 family.
Protein: ILVC_DESRM
Sequence: MVKVYYDADANLEFLKGKKIAVLGYGSQGHAQAQSLRDSGLDVVVGLRKDSARWSKAEADGLQVATVPDACAQAEVIQVLLPDEIQGRVYAEEIEPYLSEGKALMFSHGFNIHFGQIVPPKNVDVFLVAPKSPGHLVRRMYAEGKGVPGLVAVHQDYTGKAKDIALAYAKGIGCTKAGVFETSFREETETDLFGEQAVLCGGVSELIKAGFDTLVEAGYAPEMAYFECLHELKLIVDLIYEGGLSRMRYSVSNTAEYGDYMIGPRIVNEETREEMRQVLMEIQDGTFARNWMLENQVKSPQFNAVRKMEQEHPIEEVGARLREMMPWLKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: LIPB_PROM5
Sequence: MINRTSIIKQPDKISSFCDVYKLQKKYQDALISGKSNIDFIWLGEHQLCYTIGRGSNMGNLLFSLDEQDVFKIDRGGEVTCHMPGQLVTYLVLDLHNFNKDLNWYLRKIEKIIIKVLSSFNIDSSTKDGFTGVWTGERKIASIGIGCKRWVTIHGFSINVNCKLENFDKIVPCGIQGCQMANMSDYKKNLDIKEVKIIVKKIIQEEFYFNFISE
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I57A5
Sequence: MNPNQKIITIGSVSLTIATVCFLMQIAILATTVTLHFKQHECDSPASNQVMPCEPIIIERNITEIVYLNNTTIEKEICPEVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNGTIHDRIPHRTLLMNELGVPFHLGTKQVCVAWSSSSCHDGKAWLHVCVTGDDRNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIKEGKIVHISPLSGSAQHIEECSCYPRYPDVRCICRDNWKGSNRPVIDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRDPNNERGNPGVKGWAFDNGDDVWMGRTINKDSRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: MMPLC_STRCO
Sequence: MLSTLARAATRRPLTVMLLWGLFLLLGFGLGTGVFGRLSDDVPDVPGTESQVAAEHLDGLDPAGDSITGVVEAAAVADPAVRAEVRRAVADLREVAGVAEVPDPYATPGTVAEDGRALVVSVTLEGGLDDDAEEAAVDDAADRLHGIDGSAVSGVHVSGGPLLGQQLGERAQEDVKNAELISLPVVLVLLLVVFGGLRAAGLPLLVAVAGIAGAFLALFGFSHVTDISVYAIQVTTMLGLGLAVDYALLMLVRFREERRHIPDVVEAVHRTVAAAGRTVLFSGLTVAVSLAGLLVFPSTFLRSMGLAVAAVVVVDMLAALTLLPALLTRFGGRIPPAKARPEEEGRLFARLARFAARRRVAVLAVAVPALLVVALPVTGMSINLGDARQLPKSTEARQLYDAIEAHFPPGTGVSPVTVVLRPGTDTATADRIGAIAGGTTVRDLPGGTTVLELPAGGAADGPAATELVERVRDLRGDAPVQVTGSAAQLVDFRQMLADRAPWAALTVLTGIFVLLFAFTGSVLLPLRTVATTLLSLGAALGAVVWVFQDGHLAGPIGAEGLGALSLTAPPLIIAIAFGLAMDYELFILARMREARERTGDDREAVVTGLRRSGRVVTCAALLLAVVFGAFMTGGFSPILQIGLGLTLAVLIDATVVRMLLVPATMALLGRHAWWAPKPLRRAHERFGVREEAPGPAPAPPQPAAR
What are the official names of this protein?
Putative membrane protein SCO6666.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RR4_FESGI
Sequence: MSRYRGPRLKKIRRLGALPGLTRKTPKSGSNLKKKFHSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVHIAGKAKRSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVNIPSFRCKPRDIITTKDNQRSKGLVQTLMASSDPGKLPKHLTIDTLEYKGLVNKILDRKWVGLKINELLVVEY
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y3565_ARATH
Sequence: MSNNWKSVRLRLQNRTLVFLLVILSFGSCYSLKSQGDGFLESVTKDLWSDIDAEDLRAVGFHRKLLGRFRNPYTHLNAFRDRPVARATPPSSSVSTRPDAKRSSTLPPPQKSPPAQHVSAPPPFVHHVTLPSLTSSSKTSSNSTIPIVAGCIAGAVFILLLATGVFFFKSKAGKSVNPWRTGLSGQLQKVFITGVPKLKRSEIEAACEDFSNVIGSCPIGTLFKGTLSSGVEIAVASVATASAKEWTNNIEMQFRKKIEMLSKINHKNFVNLLGYCEEEEPFTRILVFEYASNGTVFEHLHYKESEHLDWVMRLRIAMGIAYCLDHMHGLKPPIVHSNLLSSSVQLTEDYAVKIADFNFGYLKGPSETESSTNALIDTNISETTQEDNVHSFGLLLFELMTGKLPESVQKGDSIDTGLAVFLRGKTLREMVDPTIESFDEKIENIGEVIKSCIRADAKQRPIMKEVTGRLREITGLSPDDTIPKLSPLWWAELEVLSTA
What are the official names of this protein?
Probable inactive receptor-like protein kinase At3g56050.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: CYH2_RAT
Sequence: MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEHELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLSVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEDLLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
What is the function of this protein?
Acts as a guanine-nucleotide exchange factor (GEF).  Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6.  Promotes the activation of ARF factors through replacement of GDP with GTP.  The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity).  Involved in neurite growth (By similarity).
What are the official names of this protein?
Cytohesin-2, ARF nucleotide-binding site opener, Protein ARNO, PH, SEC7 and coiled-coil domain-containing protein 2, CLM2, SEC7 homolog B.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection. Cell projection, growth cone. Cell junction, tight junction. Cell junction, adherens junction. Note=Recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. Requires also interaction with phosphoinositides for targeting to plasma membrane (By similarity). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas (By similarity).
Protein: EX7S_NEIMA
Sequence: MKKNAPKSFEEALSRLESLTQAMQGEMPLEDALAAYQEGNELVIYCQTKLAQVEQKLQVLDADGLKELNLESDE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_SALHS
Sequence: MTQAVMLQGTASDVGKSVLVAGLCRIFYQDGLRTAPFKSQNMALNSGITPDGKEMGRAQIFQAEAAGITPDVRMNPVLLKPTSDRQAQVVLMGKVATNMDAVSYHDYKPRLREQILAVYNSLAQEYDVIVLEGAGSPAEINLRDRDIVNMGMAEMAQCPVILVADIDRGGVFAAIYGTLALLHKQERDRVKGVIINKFRGDVALLYSGIEQIESLTGVPVLGVMPWLDVDLEDEDGVALQNDKYRGNAPRDITIAIVQLPHISNFTDFNALAAQPDVRIRYIRRPEALTDADLVILPGSKNTLSDLAWLRESGMADAVLQTHRQGVPVMGICGGYQMLGDTIVDEVESGLGTQPGLGLLNTITRFAQDKTTTQVNATMSGELPGWLAAAAGLPVRGYEIHMGETVLQEGCCTAMTLQKNGCSVADGAVTADGLAFGTYLHGLFDSDAFTRAVVNGLRARKGLAPWETTFCYAEHKARQFDLLAEAMRQHIDIDKIYTIMQQHQEPV
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: SYM_NITMU
Sequence: MNKRKILVTSALPYANGSIHLGHLVEYIQTDIWVRFQKMQEHEVHYVCADDAHGTPIMLRAEQEGITPRQLIDRVWHEHKTDFDGFHIGFDHYYTTDSPENQAFCEDIYRQLRAGELIAKRSVEQFYDPVKQMFLPDRYIKGECPRCHAGDQYGDSCEACGATYLPTDLISPYSAVSGARPERRTSNHYFFKLSDVRCEAFLKNWIFESIPAQPGVALETRPRLQPEAANKMNEWLSAGLVDWDISRDAPYFGFPIPRTGGKKFFYVWLDAPVGYFGSFKNYFKQNQRTQAEIDEFLRPGGNTEMVHFIGKDILYFHALFWPAMLEFSGYRTPTQIYAHGFLTVNGQKMSKSRGTFITAESYLKQGLNPEWLRYYYAAKLNDSMEDIDLSFEDFVARVNSDLVGKYVNIASRCAGFITKKFGGELTHNVSEASRKWFNQFLFCELGEGDTFLGRHMSIANFYERREYSKAIKEIMSAADVANQYVDRMKPWVLAKDSRNDRELHEVCSVALNMFRMLTVYLKPVLPKLAMEAEQFLGLDPLTWKDANSQHRLLPDGHRINDYQHLMTRIDPKQIEMLTHANKESLAPAKSQQVAQAVETMEKNSSTTPAPAKEGEAGQASASTISIEDFGKIDLRVAKILDAEHVPGADKLLKLTLDVASEQRTVFAGIKSAYDPGQLKGRLTVMVANLAPRKMKFGISEGMVLAAGDGEGPYLLSPDEGARPGMKVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_RICAH
Sequence: MILVNVHAGNCDNTLRNFKKKLQRELYFRKMKEQRYYETPSAKRVRKAQEAARRQRKFARKKMFDE
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: IMPG2_CHICK
Sequence: MFAFLWKISLCLLVLGVITGDPQAVAAEEKQAKDASPTPQLGVWQFASPSLPPELRKLHGIVEAEQVNRHLLRRRKRSILFPSGVKICPDESVEQAIANHLKYFRLRVCQETVWEVFKTFWDRLPEREEYHTWMSLCEEGTMSIFEMGMNFSQSEEHRSLIVKKLSYTKEAMAGSCTDWSCGGTPTPASDADATTLRDAAANVPPPHEVSIESPPGGTSHEIEDADTTINNEIKKEDEIPVRPVTEQMIEFSIVIAGEKYSEELSDPDTAKYQLLSEQFVSQIQNVFEGLPGYKNIHVLEFSSPEEDSGVEVHYAVTFDGEAISNATWDLINLHSNKVEDNSFMGIEDNPTVVYTISDFQDYIAEILQKNALLENTSLTLDPNSLQLINVKEILHPTQEDPSWITEHPTVLEHVEFDDNTFSAERPSADESTVSNTLPFDFTKPDSTLDSEESDDNEIRPRPESLDSEVSLIPEAPLSSEADVTSLPDGLXLADWNQTPALVTAPVIEHDSLDSLEWLSAPDSSDEFEDTGLSDDFLLPSSPSSHLVPEEPPSTDDYTAPLLSAPTVASSSVIETDTKRTVTAEKEVVTQGSPADSSSADSLLHEXVEESPFPLEVHPVEGEXDIYLGDRMIFDDGSGSAFDGSGKGMEPSIWPWDVATLEPVFYPGPDSWLDDDNDSLPFRTEDIPEGLILDYILNSGNKLDDDPSKDENEGVASIKENFLDESEIFVFPETTTQQVPLLQTGEPSSVETSTQMETLSMDDDSFVKPSFVLEPPEDYSFADLPTGEDLFLPHSTGVSVEDTLLTSTVTLGXEDSLLTSTVAFSVEQPEESSVGQEIISEAXEHQNEDRPTVEELFTAGQSNVGEAATVGYLDKSSLETVLTAEPFEVSTDTSTEEQQSLDSSLADRDTGLAIRKPADVWPTDRVLEKTLDQTVQSAVPTAAQVSTAVPSLIHQATALEGFAGQDGTEHDTHVSMSISTILNSYVTITADTVELPSHLPPMTTTVSSSVVTLAKVGDETTRVLDVSVDLDHVSMVSFSPEPSEEAKSMTDSHMELTTHAHSTEMAGVAWPTHEIHNSTPVPSRALVVFFSLRVTNMMFSEDLFNKNSPEYKALEQRFLELLVPYLQSNLTGFQNLEILNFRNGSIVVNSRMKFAKPVPRNVTNAVYMILEDFCNTAYHTMNLAIDKYSLDVESGEQADPCKFQACNEFSECLVNRWSGEAECVCNPGYLSIDGLPCNSICDLQPNFCLNDGKCDISPGQGAICRCRVGENWWYRGEHCEEYVSEPLVVGIAIASVAGFLLVASAVIFFLARTLRDQYTKSDTEDSQGQGDSLSSIENAVKYNPMYESDTTGYSHYYRRYPQLTSYSSTSAETSTDYSSEEIRHIYENSELTKEEIQDRIRIIELYAKDRQFAEFVRQHQMKLL
What is the function of this protein?
Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix.
What are the official names of this protein?
Interphotoreceptor matrix proteoglycan 2, Sialoprotein associated with cones and rods proteoglycan, Spacrcan.
What are the subcellular locations of this protein?
Photoreceptor outer segment membrane; Single-pass type I membrane protein. Photoreceptor inner segment membrane; Single-pass type I membrane protein. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix.