PharMolix/UniProtQA huggingface dataset:
Protein: DRE2_DROER
Sequence: MENFKGLQKSLYIWTDSADLDKRVEQLKSATGGDVALENVHRLSFSSYANSSFDLIVIECAQLTDSYVKLLHMLKPSGKLHLVSFIGPAASLLQEIKLSGFINCREDSPDALTAEKPGYETGSSARLSFAKKNASAINVWKISGDDEELIDEEELLDEEDKQKPDPAGLRVCSTTGKRKACKNCSCGLAEELETEKQSQKATENAKSSCGNCYLGDAFRCSTCPYLGMPAFKPGEKVQLGDNLLKSDI
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex.  Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase.  Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
What are the official names of this protein?
Anamorsin homolog, Fe-S cluster assembly protein DRE2 homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: AASS_BOVIN
Sequence: MLRVSRTKLGRLSPSLSRGLHHKAVMALRREDVNAWERRAPLAPRHVKGITNLGYKVLIQPSNRRAIHDKEYVKAGGILQEDISEACLILGVKRPPEEKLMPKKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGIRVVAFGQWAGVAGIINILHGMGLRLLALGHHTPFMHIGMAHNYRNSGQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEIFNELPCEYVEPHELKEVSQNGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYDKYPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKSPVAGVEGCPALPHKLVAICDISADTGGSIEFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIESTEYFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVIASNGMLSNKYKYIQKLRENREHAQSLSMGTKKKVLVLGSGYVSEPVLEYLLRDDSIEITVGSDMKNQIEQLGKKYNINPVSLHVGKQEEKLSSLVATQDLVISLLPYVLHPLVAKACIASKVNMITASYITPALKELEKSVEDAGITVIGELGLDPGLDHMLAMETIDKAKEVGATIESYVSYCGGLPAPECSDNPLRYKFSWSPVGVLMNIMQPATYLLNGKVVNAVGGVSFLDSVTPMDYFPGLNLEGYPNRDSTKYAEIYGIPSAHTLLRGTLRYKGYAKALSGFVKLGLINRDAFPALQPDANPLTWKELLCDLVGISSSSKCDVLKEAVFKKLGGDTTQLEALEWLGLLGDEQVPQAESLVDALSKHLAVKLSYGPGEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDVNGFSAMAKTVGLPTAMAAKMLLDGEIQAKGLMGPFSKEIYGPILERIKAEGIMYTTQSTIKL
What is the function of this protein?
Bifunctional enzyme that catalyzes the first two steps in lysine degradation.
What are the official names of this protein?
Alpha-aminoadipic semialdehyde synthase, mitochondrial, LKR/SDH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the saccharopine dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TRPB1_METMA
Sequence: MAAAIISELQVKGKYGKYGGQYVPEVLMPALEELEEGYERYKNDPEFLAELDHYLRDFAGRETPLYLARNLSKKYGTKIYLKREDLVHGGAHKLNNAIGQALLAKYMGKTRLIAETGAGQHGTATAMAGANLGFETVVYMGAKDVKRQQMNAYRMELMGTEVKPVKTGSKTLKDAINEAFRDWVTNIGNTHYLIGSVVGPHPYPMIVRDFQSVIGREVKEQAMEKEGRLPDTIIACAGGGSNAMGTFYPFIEDRDVRLIAVEAGGKALRCTEKAALHSASLCAGEEGILHGARTKVLQDKNGQILESESVSAGLDYSGVGPELASLAESGRVTARYVTDDEAVEAFNELSRLEGIIPALESSHALAYLKKAAESGELGEFVVVNLSGRGDKDLETVLSLKRGI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain 1.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: SYP_EHRCR
Sequence: MRLSDYYVPTLKETSADISVISHKYSIRAGLIKQIASGIYTWLPLGLKVLKNIENIVREEMNKSGSLEILMPLIQPASLWKESGRYDDYGSEMLRITDRNQREMLFGPTHEEVITDILRTTPVSHKDLPLILYQIQWKFRDELRPRYGIMRCREFLMKDAYSFDKDFSGAISSYNLMFKTYIKIFQKLGLTPIAVKADSGPIGGNLSHEFHVLANSGESTLYYDQDIIELMNSESIDVEKIKNTYTAADDMHDPQACPISSDKVKISKGIEIGHIFHLGDKYSKPMNANFCDSNNNKLLQMGCYGIGVSRLVAAIIEVFHDNKGIIWPETVAPFKFSLVNLYTSNDKCKKVAENLHMQLYDDVLYDDTDDSPGIKLARTDLLGMPWQVIIGKSTVEQDLIEVRNRLTKDKVLISTEQFLNKLKK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_BACMK
Sequence: MKVAIIGATGYGGIELIRLLEQHPYFSIASLHSFSQVGEFITNVYPHFRNVLVHTLQEIDAEKIEKEAEIVFLATPAGVSAELTPKLLAVGLKVIDLSGDFRMIDPSSYELWYKRPAAQEELLRKAVYGLSEWKRPEIQNANLIANPGCFATAALLAVAPLVRSGIIEEASIIIDAKSGVSGAGKTPTTMTHFPELYDNLHIYKVNQHQHVPEIEQMLTEWNRETKPITFSTHLIPISRGIMITLYAKVKEEMKIEQLQKLYEETYEYSAFVRVRSQGEFPSPKEVRGSNYCDIGIAYDERTERVTVVSVIDNMMKGAAGQAVQNANLLAGLEETTGLQHMPLYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_RHOP2
Sequence: MSKPKRERVLPDNEAKAVARMLRVSPQKLNLVAQLIRGRKAAAALADLQFSRKRIAVDVKKCLESAIANAENNHDLDVDALVVSEAHVGKGIVMKRFSPRGRGRSGRILKPFAQLTIVVRQVEAEASA
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: BOP1_DROMO
Sequence: MTKKRTVKRKVKEPEPTKEQPSVSEQSENEEDEDLLQAVKDPGEDTTDDEGIDQEYQSDSSEDLEFESDEEGNYLGRKVSNEAEEGEDDQDEDDDEDEDEGEDEDDDSDDDSEESDANEASATPKDDQPSSSKAAAAQTKEPIIQIIPRDPSKPEYEESDTSDEEDIRNTVGNIPMHWYDEYKHIGYDWDAKKIIKPPKGDQIDDFLRKIEDPNFWRTVKDPMTGQEVLLTDEDIALIKRVNSSRIPNPEHDEYAPWIEWFTSEVEKMPIKNVPDHKRSFLPSVSEKKKVSRMVHALKMGWMKTTEEVEREKQQKRGPKFYMLWETDTGREHMRRIHDPVSAPKRDLPGHAESYNPPPEYLFDEKETKEWLKLKDEPHKRKLHFMPQKYKSLRAVPAYSRYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRDLQPFPTVESLVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIETNDVVRCVAWCPNAKLSIIAVATGSRLLLINPKVGDKLLIKKTDDLLAESPNLDIIESERIKTAVQWSNAEPDEQEKGVRVVITHFKPIRQVTWHGRGDYLATVMPEGANRSALIHQLSKRRSQIPFSKSKGLIQCVLFHPVKPCFFVATQHNIRIYDLVKQELIKKLLTNSKWISGMSIHPKGDNLLVSTYDKKMLWFDLDLSTKPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIVSHGMVYNDLLQNPLIVPLKKLQTHEKRDEFGVLDVTWHPVQPWVFSTGADCTIRLYT
What is the function of this protein?
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein BOP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BOP1/ERB1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: PGFS_TRYCC
Sequence: MNCNYNCVTLHNSVRMPQLGLGVWRAQDGAETANAVRWAIEAGYRHIDTAYIYSNERGVGQGIRESGVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWPGKKKFVDTWKALEKLYEEKKVRAIGVSNFEPHHLTELFKSCKIRPMVNQVELHPLFQQRTLREFCKQHNIAITAWSPLGSGEEAGILKNHVLGEIAKKHNKSPAQVVIRWDIQHGIVTIPKSTNKGRIQENFNVWDFKLTEEEMRQIDELNEDKRIGGDPDNFFPGGEEA
What is the function of this protein?
Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2.  Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
What are the official names of this protein?
9,11-endoperoxide prostaglandin H2 reductase, Prostaglandin F2-alpha synthase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_GEOSW
Sequence: MIFVLDVGNTNTVLGVYDGDELKHHWRIETSRGKTEDEYAMTIKALLNHVGLQFSDIDGIIISSVVPPIMFALERMCLKYFHIKPIIVGPGIKTGLNIKYDNPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEHKQYMGGAIAPGIMISTEALFARAAKLPRIEIARPDDIIGKNTVSAMQAGILYGYVGQVEGIVSRMKAKSSVPPKVIATGGLASLIASESSVIDIVDPFLTLTGLKILYEKNVDKKQ
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_HYDS0
Sequence: MKYLLIKFVRFWQICISPLYPSSCRFYPTCSHYAILSIEKYGAFKGGMKAFWRILRCNPWNKGGIDYP
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ING3_XENTR
Sequence: MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVGEFFMNAKKNKPEWREEQMASIKKDYFKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDTPSQPVNNHHVHSHSLGEKRKHNPSSHHSTTDHVSEKKFKSEALLSTLTSDASKENTAGCRNNLSSSSTNNVYNVNASQPLTSYNISSLSTGAGAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNNDFQLGISLSRDSATYSSSALASTLTQTLTSSATTDSRSGRKSKSNNKSASQQSSSSSSSSSLSSCSSSSALAHELSHQQTAAIPESDTNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLSEAPKGKWYCPQCTAAMKRRGSRHK
What is the function of this protein?
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity).  NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity).
What are the official names of this protein?
Inhibitor of growth protein 3.
What is the protein family that this protein belongs to?
Belongs to the ING family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSDD1_ARATH
Sequence: MVMEVTETERWCVVTGGRGFAARHLVEMLVRYQMFHVRIADLAPAIVLNPHEETGILGEAIRSGRVQYVSADLRNKTQVVKGFQGAEVVFHMAAPDSSINNHQLQYSVNVQGTTNVIDACIEVGVKRLIYTSSPSVVFDGVHGTLNADESLPYPPKHNDSYSATKAEGEALILKANGRSGLLTCCIRPSSIFGPGDKLMVPSLVTAARAGKSKFIIGDGSNFYDFTYVENVVHAHVCAERALASGGEVCAKAAGQAYFITNMEPIKFWEFMSQLLEGLGYERPSIKIPASLMMPIAYLVELAYKLLGPYGMKVPVLTPSRVRLLSCNRTFDSSKAKDRLGYSPVVPLQEGIKRTIDSFSHLKAQNQPKTEVTETIQWKKQTLIAIVILITLYHNFVATTGSSSVIITAVSKVLLVSSIFMFINGILPEKMKVFGSKKID
What is the function of this protein?
3beta-hydroxysteroid-dehydrogenase/decarboxylase involved in sterol synthesis (PubMed:16835224).  Catalyzes the formation of 3-oxosteroids from 3beta-hydroxysteroids-4alpha-carboxylate (PubMed:16835224).  Involved in the regulation of inflorescence internodes and leaves growth, probably by affecting auxin transporter activity possibly by altering sterol composition in the membranes (PubMed:22673766).
What are the official names of this protein?
3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1, At3BETAHSD/D1, 4alpha-carboxysterol-C3-dehydrogenase/C4-decarboxylase isoform 1-1, Reticulon-like protein B24, AtRTNLB24, Sterol-4-alpha-carboxylate 3-dehydrogenase 1, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 3-beta-HSD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RLMKL_KLEP3
Sequence: MNSLFASTARGLEELLKTELEGLGATDCQVVQGGVHFQGDTRLLYQSLMWSRLASRIMLPLGECRVYSDLDLYLGVQAIPWTEMFNPGATFAVHFSGLNDEIRNSQYGALKVKDAIVDSFTRKNLPRPNVDRESPDLRINVWLNKETAHISLDLSGEGLHLRGYRDGTGMAPIKENLAAAIVMRSGWVPGTPLLDPMCGSGTLLIEAAMLATDRAPGLHRGHWGFGGWAQHDDAIWKEVKAEAQTRARQGLAAYGSRFYGSDVDERVIERARRNARRAGIGELIDFAVKDVAQLNNPLPKGPYGTVISNPPYGERLESEPALIALHSLLGRIMKSQFGGWNLSVFSASPELLSCLQLRADKQFKAKNGPLDCIQKNYHLAESEGGKPAMLAEDFANRLRKNLKKFEKWARQEGIECYRLYDADLPEYNVAIDRYGDWVVVQEYAPPKTVDAHKARQRLFDIIAATIAVLEIAPNKLVLKTRERQKGKNQYQKMAEKGDFIEVQEYNARLWVNLTDYLDTGLFLDHRIARRMLGQMSKGKDFLNLFSYTGSASVHAGLGGARSTTTVDMSRTYLEWAERNLRLNGLTGRAHRLMQADVLGWLRESTEQFDLIFIDPPTFSNSKRMEDAFDVQRDHIRLMTDLKRLLRKGGTIMFSNNKRGFRMDHDGLAALGLKAQEISQKTLSQDFARNRQIHNCWLITAA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_CERSP
Sequence: MSYIPFPDISPELFSIELFGVTFALRWYALAYIAGLLIGWRLVLRMIRAERLWSFGPPMTEDQLERLLTWVILGVILGGRLGFVLFYQPAHYLAHPLDILKVWEGGMSFHGGFLGVMTALVAFCLKERISILPVADLLAAATPPGLFLGRIANFINAELWGRPTTLPWGVAFPGEAAQSCPGIEGICARHPSQIYEAGLEGI
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RF1_PSEF5
Sequence: MKASLLSKLDILQDRFEELTALLGDAEVISDQAKFRAYSKEYAEVEPIVATYKQVLKVQADLEGAQALLKDNDPDLREMAAEEVREAKEQLAELESSLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRLEILSENEGEHGGYKEVIARVEGESVYGKLKFESGAHRVQRVPATESQGRIHTSACTVAVLPEPDEQEAIEINPADLRIDTYRSSGAGGQHVNKTDSAIRITHIPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQTSAAANAIASERKLLVGSGDRSERIRTYNFPQGRVTDHRINLTLYSLDEILAGGVEAVIEPLLAEYQADQLAALGE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_BORPD
Sequence: MSAAALKNDVFLRALLRQPVPYTPIWLMRQAGRYLPEYNATRARAGSFMGLAQNPDYAAEVTLQPLARYDLDAAILFSDILTVPHAMGLGLDFAPGEGPRFARPLRTEDDVARLAVPDMESLRYVFDAVAVIRRELDGKVPLIGFAGSPWTIACYMVEGRGSDDYRLIKTMLYARPDLLHRILEVNAQATLQYLNAQIQAGAQAVMLFDSWGGVLADGLFQQFSLAYTRKVVAGLIREHQGRRVPAIVFTKGGGQWLEAIAACGCDAIGLDWTVNLGQARQRTGDAVALQGNLDPMTLFGGSEAIRAEARRTLDAFGPVGTGGHVFNLGHGISQYTPPEAVAELVDEVHTYSRALHAK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MELK_CAEEL
Sequence: MSKYEVLQGFYAVHDELGSGGFGKVRLATHLLTNQKVAIKIIDKKQLGHDLPRVQTEMDALRNLSHQNICRLYHYIETEDKFFIVMEYCSGGEMFDYIVRKERLEESEARHFFRQLVSAIAFVHSQGYAHRDLKPENLLLTEDLHLKLIDFGLCAKTEKGRIDKHNLDTCCGSPAYAAPELIQGLQYKGNEADVWSMGILLYTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDWLNHKYTQPVKWNTIYDKNFIDRDVARVMSKYYGFESTDKMIEKIKEWNFDYMTSTYYALLHRKRNGMEIILPMVRNSTNTAPPNVQNILCSPTIHASLENNLDKSGLEDDDSDPSSISSSSDISARLKKNCVVSDESSSSRFVKPMSPAAEKDKKMSYVNAMLTMPSQFTGRSPLRIPESPMSVRSSDSASLGSAATPSRGGVKDNDKENASTGKNYRMGASTCKSRGPLKITGVEEGTMKSVYTTPNTRPTLRGLFSPGNAEHKKRQRARSSDRASIGMPPGSPVSIGSAHSANNELLADGRTPRSRIKTNRLPQRVFTSLERKKEKLITLLTPRKMQRDSPQVLKDVKNMVNVSMTASQDPEEVRNLLKKVFDDERMRYELNGWKFLATQETVHGWMTVELEIVRLQMFDKVGIRRKRLKGDAFMYKKVCEKILQMAKIE
What is the function of this protein?
Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants (PubMed:16774992, PubMed:20929735, PubMed:23946438, PubMed:23267054, PubMed:23851392, PubMed:28659600).  Plays a role in neural fate specification in several dopaminergic linages, acting in concert with ham-1 (PubMed:28659600).  Involved in phosphorylation of multiple proteins associated with key developmental processes, including the cell cycle, apoptosis, endocytosis, and asymmetric cell division (PubMed:28659600).  Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface (PubMed:22801495).  May act downstream of par-4/strd-1/mop-25 to regulate cell shedding (PubMed:22801495).
What are the official names of this protein?
Maternal embryonic leucine zipper kinase, MELK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in undividing cells and co-localizes with centrosome in dividing cells.
Protein: FUMC_MYCBO
Sequence: MAVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_CORGB
Sequence: MANVNIKPLEDKILVQINEAETTTASGLVIPDSAKEKPQEATVIAVGPGRFDDKGNRIPLDIKEDDVVIFSRYGGTEIKFGGVEYLLLSARDILAIVEK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMG_SHELP
Sequence: MFDILMYLFENYVHSEVELLVDEDELTQELTRAGFHQSAIIKALSWLEHLASLQESDQPYLCNHDQHSFRIYTQAEMEKLDVECRGFLLFLEQIKVLNVELREMVIDRVMELDEPALILEDLKWVILMVLFNVPGNESAYEQMEDLIFEQPDGRLHS
What are the official names of this protein?
Protein Smg homolog.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: RL15_STRSC
Sequence: GQMPLHMRLPKLKGFKNPFKTEFQVVNLDKLAALYPEGGEVTVADLVAKGAVRKNSLVKVLGQGEISVALQVTVDAVSGSAKEKITAAGGTVTELV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: G3P_BPPF3
Sequence: MGLHYLFGFCLALFSFSAIAAGPVSTEVAAGTTTYRVTNTTVRTPPNVTLSPVRDITPYVEKIPNKGLAQAAQGRLIVAQRAASVPVTGFFNVSGAVVKSGAKSFLRSAGRASGIGLGLAALLEAADWVFDEEGEIVKPLPGGGSPVLMPRPVILNEYTVTGSAGQWSISKEYEPDPRSVPGWYSYNGNPVWVSAVEDVGFTWRYWYFADVLMDGQGRPNYLVAYSDSGPNEYWQDVGGYSLDSLPTEPEFVPLTDAELEAGIDQYYEPDPDDWRNLFPYIEPDSFTIETPIPSLDLSPVVSSSTNNQTGKVTVTETTTSVDFEVSDNNSSQPSISVNETTTENVYVDGDLVSSETNTTVTNPPSSGTSTPPSSGSGSDFQLPSFCSWATAVCDWFDWTQEPIDEEPDLSGIISDIDDLERTKDISFGSKSCPAPIALDIEFLDMSVDLSFEWFCELAGIIYFMVMASAYVLAAYITLGVVRG
What is the function of this protein?
Plays essential roles both in the penetration of the viral genome into the bacterial host via pilus retraction and in the extrusion process.  During the initial step of infection, G3P mediates adsorption of the phage to its primary receptor, the tip of host type IV PAO pilus.  Subsequent interaction with the host entry receptor induces penetration of the viral DNA into the host cytoplasm.  In the extrusion process, G3P mediates the release of the membrane-anchored virion from the cell via its C-terminal domain.
What are the official names of this protein?
Attachment protein G3P, Gene 3 protein, G3P, Minor coat protein.
What is the protein family that this protein belongs to?
Belongs to the inovirus G3P protein family.
What are the subcellular locations of this protein?
Virion. Host membrane; Single-pass type I membrane protein. Note=Prior to assembly, G3P is found associated with the bacterial host inner membrane. There are about five copies of this protein per mature phage that are located on the head side of the filamentous virion.
Protein: KDPA_METPP
Sequence: MNSQAWIQLAVFLALLMLLAWPLGRWLAAVAEGHLPQGLAPFCRVETALYRAAGIDAAVGMGWKAYALALLAFNALGALAVYALQRLQGGLPLNPQGLPGVGADSSLNTAVSFVSNTNWQGYAGETTMSYLTQMLALGVQNFLSAATGIAVAFALIRGFAARSSSAIGNFWVDVTRITVYVLLPLSLVFAVFLVSQGVIQNVQPYQDVSTLEGAASTPQTLAMGPVASQEAIKMIGTNGGGFFNANSAHPYENPTPLSNFAQMLAIFLIPAGLVFAFGRLVGDVRQGGALLAAMTVMFVLAVVTVTSLEQRGHPQLAALGVDPVASALQAGGNMEGKEARFGIAASALFAAITTAASCGAVNAMHDSFMPLGGAVPLLLIQLGEVVFGGVGSGLYGMLVFAILAVFIAGLMIGRTPEYLGKKIEPYEMKMTAVVILVTPLLALLGTAVALTAPTGPAGMGNPGPHGYTEILYALSSAANNNGSAFAGLSANTPFYNLLLAVAMWFGRFGVIVPVLAIAGSLAAKKRLPVTAGTLPTHGPLFVVLLIGAVLLVGLLNYVPALALGPVVEHLMQAAAR
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPI_CITSI
Sequence: MNVLSCSMNTLRGLYDISGVEVGQHFYWQIGGFQVHAQVLITSWVVIAILLGSAFIAVRNPQTVPTATQNFFEYVLEFIRDVSKTQIGEEYGPWVPFIGTLFLFIFVSNWSGALLPWKIIELPHGELAAPTNDINTTVALALLTSIAYFYAGLSKKGLGYFSKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.