PharMolix/UniProtQA huggingface dataset:
Protein: FABH_STRPI
Sequence: MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRHISRTESTSDLATEVAKKLMAKAGITGEELDFIILATITPDSMMPSTAARVQANIGANKAFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDGAGGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVFDFAIRDVAKSIKQTIDESPIEVTDLDYLLLHQANDRILDKMARKIGVDRAKLPANMMEYGNTSAASIPILLSECVEQGLIPLDGSQTVLLSGFGGGLTWGTLILTI
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_PSEPK
Sequence: MQISVNEFLTPRHIDVQVVSPTRAKITLEPLERGFGHTLGNALRRILLSSMPGCAVVEAEIDGVLHEYSAIEGVQEDVIEILLNLKGLAIKLHGRDEVTLTLSKKGSGVVTAADIQLDHDVEIVNPDHVIANLASNGALNMKLTVARGRGYEPADSRQTDEDESRSIGRLQLDASFSPVRRIAYVVENARVEQRTNLDKLVIDLETNGTLDPEEAIRRAATILQQQLAAFVDLKGDSEPVVVEQEDEIDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLDNWPPASLKKDDKATA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: YCEH_SALTI
Sequence: MKYELTATEARVIGCLLEKQVTTPEQYPLSVNGVVTACNQKTNREPVMNLTEQEVQEQLDNLVKRHFLRTVSGFGNRVTKYEQRFCNSEFGDLKLSAAEVALVTTLLLRGAQTPGELRSRASRMHEFSDMAEVESTLERLASREDGPYVVRLAREPGKRESRYMHLFCGDVDELSLQTSAPESASGDLQSRVEALESEVAELKQRLDSLLAHLGE
What are the official names of this protein?
UPF0502 protein YceH.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: ILF3_MOUSE
Sequence: MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKADPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSNFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAIVAPPPVVEAVSNPSSVFPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALEANKKKRTPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNIRGRGRGGNIRGRGRGRGFGGANHGGGYMNAGAGYGSYGYSSNSATAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDSYNSPVPPKHAGKKPLHGGQQKASYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSYSSYSNSYNSPGGGGGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSSYNTGSHGGYGTGSGGSSSYQGKQGGYSSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR
What is the function of this protein?
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs.  Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons.  Plays thereby a role in the back-splicing of a subset of circRNAs.  As a consequence, participates in a wide range of transcriptional and post-transcriptional processes.  Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity).  Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response.  Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs.  In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs.
What are the official names of this protein?
Interleukin enhancer-binding factor 3.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: RL21_ALCBS
Sequence: MYAVIKTGGKQYRVEEGDVVRIEKIEVATGESVDFDQVLLVANGDDVKVGQPMLDGAKVTAEVLEQGRHKKIKIVKFRRRKHSRKQQGHRQWYTAVKITGIQG
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: CHMU_EMENI
Sequence: MDTAIDLSDASKALDLANIRFQLIRLEDTITFHLIERVQFPLNKTIYIPGGVKIPNEQISLMDYLLRETERLQSRVRRYQSPDEYPFFPSALEKPILQPLDYPKILHDNDVNVNETIKTRYVQDILPAICPQFGGREDRGETQENYGSAATCDVSCLQALSRRIHFGKFVAESKFQKETEKFVALIKAGDRKEIDEAITDAKVEQKVLERLALKAKTYGTDPGFPEQSGPKIDVQAVQDMYKEYVIPLTKVVEVEYLMQRLKGTQWE
What is the function of this protein?
Catalyzes the Claisen rearrangement of chorismate to prephenate (PubMed:10428795).  Acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan (By similarity).
What are the official names of this protein?
Chorismate mutase, CM, AnCM.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2B1_DEBHA
Sequence: MAPKAEKKPASKAPAEKKPAAKKTASATGTKKRSKTRKETYSSYIYKVLKQTHPDTGISQKAMSIMNSFVNDIFERIAGEASKLAAYNKKSTISAREIQTAVRLILPGELAKHAVSEGTRAVTKYSSAAN
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.1.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: KT33B_HUMAN
Sequence: MPYNFCLPSLSCRTSCSSRPCVPPSCHGYTLPGACNIPANVSNCNWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQKILCSKSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDINSLRRILDELTLCRSDLEAQMESLKEELLSLKQNHEQEVNTLRCQLGDRLNVEVDAAPAVDLNQVLNETRNQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHNLRYSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEINTYRSLLESEDCKLPSNPCATTNACEKPIGSCVTNPCGPRSRCGPCNTFGY
What are the official names of this protein?
Keratin, type I cuticular Ha3-II, Hair keratin, type I Ha3-II, Keratin-33B, K33B.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: CYSZ_ECOL5
Sequence: MVSSFTSAPRSGFYYFAQGWKLVLQPGIRRFVILPLLVNILLMGGAFWWLFTQLDVWIPTLMSYVPDWLQWLSYLLWPLAVISVLLVFGYFFSTIANWIAAPFNGLLAEQLEARLTGATPPDTGIFGIMKDVPRIMKREWQKFAWYLPRAIVLLILYFIPGIGQTVAPVLWFLFSAWMLAIQYCDYPFDNHKVPFKEMRTALRTRKITNMQFGALTSLFTMIPLLNLFIMPVAVCGATAMWVDCYRDKHAMWR
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEXA_SYNWW
Sequence: MNNELKLGKRQKQILDFIKQSCKEKGYPPSVREIGQAVGLKSSSTVHTHLVRLEEKGLIRRDPAKPRAIIPLDDEPLLQSEALSVPVIGNVAAGSPILAEQNIDNYLSIPVDFLGSGNHFILKVKGDSMIEAGILDGDYLIVREQADASNGEIVVALLDNEATVKRFYRRDDYVELRPENALMDPITVNNVQVAGKVAGLLRRI
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: F17DG_ECOLX
Sequence: MTNFYKVFLAVFILVCCNISQAAVSFIGSTENDVGPSPGSYSRTHAMDNLPFVYNTGNNIGYQNANVWRISKGFCVGLDGKVDLPVVGSLDGQSIYGLTEEVGLLIWMGDTNYSRGTAMSGNSWENVFSGWCVGANTASTQGLSVRVTPVILKRNSSARYSVQKTSIGSIRMRPYNGSSAGSVQTTVNFSLNPFTLNDTVTSCRLLTPSAVNVSLAAISAGQLPSSGDEVVAGTTSLKLQCDAGVTVWATLTDATTPSNRSDILTLTGASTATGVGLRIYKNTDSTPLKFGPDSPVKGNENQWQLSTGTETSPSVRLYVKYVNTGEGINPGTVNGISTFTFSYQ
What is the function of this protein?
Essential fimbrial adhesion factor that mediates binding to N-acetylglucosamine-containing receptors in the host intestinal microvilli, leading to colonization of the intestinal tissue, and diarrhea or septicemia.  Also confers adhesiveness to laminin and basement membranes (By similarity).
What are the official names of this protein?
F17d-G fimbrial adhesin.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium. Note=Attached to the tip of the fimbrial filaments.
Protein: TPM_SCHPO
Sequence: MDKLREKINAARAETDEAVARAEAAEAKLKEVELQLSLKEQEYESLSRKSEAAESQLEELEEETKQLRLKADNEDIQKTEAEQLSRKVELLEEELETNDKLLRETTEKMRQTDVKAEHFERRVQSLERERDDMEQKLEEMTDKYTKVKAELDEVHQALEDL
What is the function of this protein?
Forms part of the F-actin contractile ring during cytokinesis.
What are the official names of this protein?
Tropomyosin.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: YIDC_HELHP
Sequence: MYRPNEQDNGMSLTRVLIAIGLSIAFFAIYAYFFPQKPHQNTHQAHTAQNTQDTQESIQASTHTEINTQVAPHQNIQDSTQSVQNEISSSAQMPHSLKQTIIARVDSDEFELEIDALGRIKQVYLKDEKFIRHEQTSLFAMIGEVLGMKPAHKEKRDKLPLFGDSQLHTMEMRFSDTSINQQAFDTPYTANISYIKLENAPVEIVLTQNLGNLVIKKYLTIHPNLAYDVRLELSKPNIEYFVSNGMRPTADTDTYAFRGVITRNNIDGVLTKFEDGDASSDYLAKNAADIRSSSFVASVDRYYTSLFFSNAPKGLYVVMSGDNAHNPMPYVRFEGDAEFAGYIGPKEYHELQGIENTLTDVVEYGRITFFAKPLFLLLEYLYDLCGNWGWAIVLLTLIVRIVLYPLTYKGMVSMQKLKDLAPKMKDLQTRYKDDPQKLQIHMMDLYKKHGANPLGGCLPLILQIPVFFAIYRVLHNAVELKSSAWILWITDLSAIDPYFVLPVLMGVSMYISQKLTPSNFTDPMQEKIFKMLPWVFTIFFIIFPFPAGLVLYWTINNVFSIIQQISINKIMEGKKAKEIAAHHDEKTNKRG
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CITD_ECOL5
Sequence: MKINQPAVAGTLESGDVMIRIAPLDTQDIDLQINSSVEKQFGDAIRTTILDVLARYNVRGVQLNVDDKGALDCILRARLEALLARASGIPALPWEDCQ
What is the function of this protein?
Covalent carrier of the coenzyme of citrate lyase.
What are the official names of this protein?
Citrate lyase acyl carrier protein, Citrate lyase gamma chain.
What is the protein family that this protein belongs to?
Belongs to the CitD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_ERYLH
Sequence: MARFLIVEARFYDHLNDMLVAGARAALEAEGHEAEVLTVPGALEVPGAIAMAAENGEFDGFVAIGVVIRGETYHFEIVAGESARGILALTMDGIAIGNGILTTENEEQALERADPARKDKGGEAAKAAIALLKLQDRFGA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: SYL_AERPE
Sequence: MERLKAVEEKWQERWREARLFEADPQPGRRKFFITFPYPYVNAYPHLGSAFTILRVDIMARYKRMRGYNVLFPQGWHATGGPIVSSALRVREGDPRIIKTLRDMGIPEEDIPRFRDPRYWVEFFTKAWRRDLERYGMSIDWRREFYTTSLNPAYSRFIEWQYLKLREKGFVGKGRHPVVWCPKEQKVVGDHDRPDEYAGISPQEAVIIKFRGRDGLVYPALTYRPETVFGVTNLWVHPDATYLVAEVDGEERWIIGEQAARELADQGHRVVILERIEGRRLLGRIVVNPADGREVPVLPASFVRPDLGTGVVMSVPAHAPYDYVALMELKRRPETLREYGLEPGVVESLEPIQLIAVPRAEGLLVVEEVRRRGVESQMDREKLDEATREVYAREFYEGIMLETTGRFSGLKVAEAKEKVVEWLEERGAALRIYTLPQEVYCRCGARTHVKIVEDQWFLLYSKPEWKALAREAVARMEFLPGHVRRDFEAIIEALRDWAFTHKGELGTPLPWDREWVIESLSDSTIYMAYYTIAKYTQHPEKYGVEPEMLTPEVFDYVFLGAGDPGEVSRRSGIPQGLLEEMRREFLYWYPLDMRISGKDLIPNHLVFFIFHHTAIFPRELWPRAIGVNGWVLVAGEKMSKSKGNFILLRQALDWWGADATRWAEVLAGADSGLDDANFEPSVADSAVSLLSQWLDFVRENYGRPARREERWVDRWFESRLNSTIARVTRLMEEANFKTALVEAWYKLQESYRWYLRRSGGEPREDLLRRFIEVQTLLIAPFAPHTAEEAWEAMGREGFASTASWPEPDESKISPEVEAAEETVQAVLEDAREVLSLIGGADTLVVTVAAEWKYRAVEAVRRARERGASMKEALREAFKVEGVDKREAARLVQQLSRAPEVLRRAAPRSVELEALRDAAQLLQEELGVKVVVETEEDGGSPRRANALPGRPALYAEKRGG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GB_BHV2B
Sequence: MAISRRSLHAIILTVLLLAATAAPSQSGSRSRSRRKSERQSTNRGRDNNSIRGGVAQTPESSPLPALDLTPQPPMEKEEPDTLAPRASRDAPGTPKVPAMPGVTPEPSGNASEPADPAELRADLRGLKGSSDDPNFYVCPPPTGATVVRLEEPRPCPELPKGLNFTEGIAVTFKENLAPYKFKATMYYKAVTVASVWSGYSYNQFMNIFEDRAPIPFEEIVDRIHGRGMCLSTAKYVRNNLETTAFHNDADEHEMKLVPAESAPGLHRGWHTTRLKNNPTGSAWIHRHGTTVDCIVDEVEAKSSYPYNEFVLATGDFVYASPFFGYRDGSHSEHNAYAADRFKQVDGFFPRDFGTGRRHGSPVTYNLLTTPMFTVGWNWAPKRPSVCTMTKWREVPEMLRAEYGSSFRFTSNALSATFTTNLTQYSLSRVDLGDCVGKEAREAIDRIYLEKYNNTHLRVGSVQYYLATGGFLIAYQPLLSNNLADLYVKELMREQALKPEERKLNATTDGKVITTTSSVEFARLQFTYNHIQKHVNEMFGRMAVSWCELQNQELTLWNEAKKINPSAIASVTLHRRVSACMLGDVLAISTCVAVPAENVIMQNSMRIPSKPGTCYSRPLLSFKHVDGEELMEGQLGENNEIRLDRDAVEPCSVGHKRYFLFGAGYVYFEEYTYSHQLSRSDITAVSTFIDLNITMLEDHEFVPLEVYTRQEIKDSGLLDYAEVQRRNQLHALRFADIDTVIKADPNAAIFAGLHGFFEGLGDVGRAVGRVVLGVVGGVVATVSGVSSFLSNPFGALAIGLLVLGGLVAAFFAFRYVMRLQRNPMKALYPLTTKDLKHPSEGGGGEEAMEDFDEQKLDEARSMIKYMALVSAMERTKHKAGRRGGTSAILNARLTDMVMRKRGAKPKYEALPETDEDI
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: UNG_PECCP
Sequence: MATSLTWHDVLAQEKQQPYFINTLEFVGKERAAGKTIYPPQKDVFNAFRFTELHQVKVVILGQDPYHGPNQAHGLSFSVRPGVPAPPSLANIYKELASDIPGFEIPRHGFLQSWAEQGVLLLNTVLTVEAGQAHSHANLGWETFTDRVIAALNEQREGLVFLLWGSHAQKKGNIIDQRRHHILKSPHPSPLSAHRGFLGCKHFSQANQLLEQQGLSPIDWTPRLPEEA
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASL3_SARSH
Sequence: MGSLTDNAAIPTVDISAFLDPNASQEARQDVVNAMSNACHVYGFFNLAGHGIPQETLREAFELNKMFFALPEESKKEVLISKSIGQSFRGYEPPGIQTHHKGLLPDIKETFMVGREVPLDDPDCGTFSTGPNLWPSSLPKEKFQDRIMAYQGSMLELVKNILAILAQGLPKEWGCSPTVFNSLLDKPSIPMRFLHYAPVPSQLEDVRQFGVADHTDFGCVSILLQEPGTSGLEVYYPPSDSWIPVPVIDDGFVINMGDMMQRYTGGYYRSARHRVLTNREKHRHSVAFFLNGNLGLKAKALDGSETETVVGDWIRGRLIDTMGQTGKLLQRESPKPVVLP
What is the function of this protein?
2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of xenovulene A, an unusual meroterpenoid that has potent inhibitory effects on the human gamma-aminobutyrate A (GABAA) benzodiazepine receptor (PubMed:29773797).  The first step of xenovulene A biosynthesis is the biosynthesis of 3-methylorcinaldehyde performed by the non-reducing polyketide synthase aspks1 (PubMed:17912413, PubMed:29773797, PubMed:20552126).  The salicylate hydroxylase asL1 then catalyzes the oxidative dearomatization of 3-methylorcinaldehyde to yield a dearomatized hydroxycyclohexadione (PubMed:29773797).  The 2-oxoglutarate-dependent dioxygenase asL3 further catalyzes the oxidative ring expansion to provide the first tropolone metabolite (PubMed:29773797).  The cytochrome P450 monooxygenase asR2 allows the synthesis of tropolone hemiacetal (PubMed:29773797).  In parallel, a previously unrecognised class of terpene cyclase, asR6, produces alpha-humulene from farnesylpyrophosphate (FPP) (PubMed:29773797).  The putative Diels-Alderase asR5 probably catalyzes the formation of the tropolone-humulene skeleton by linking humulene and the polyketide moiety (PubMed:29773797).  Oxidative-ring contractions catalyzed by asL4 and asL6 then processively remove carbon atoms from the polyketide to yield xenovulene A (PubMed:29773797).
What are the official names of this protein?
2-oxoglutarate-dependent dioxygenase asL3, Xenovulene A biosynthesis cluster protein L3.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: TPMT_RAT
Sequence: MSLGIKEHPDAEVQKNRVLTLDDWQDKWVTRHIAFHQEQGHQLLKKHFDTFLKGQSGLRVFFPLCGKAIEMKWFADRGHTVVGVEISEIGIREFFAEQNLSYTEEPLTEIAGAKVFKSSSGNISLYCCSIFDLPRANIGKFDRIWDRGALVAVNPGDRDRYADIILSLLRKGYHYLLVVLSYDPTKHTGPPFYVPDAELKKLFGTKCNMQCLEEVDALEERHKTWGVDYFFEKLYLLTEK
What is the function of this protein?
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor.  TPMT activity modulates the cytotoxic effects of thiopurine prodrugs.  A natural substrate for this enzyme has yet to be identified.
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GON2_RUTRU
Sequence: MVHICRLLVLMGMLLCLSAQFASSQHWSHGWYPGGKREIDIYDTSEVSGEIKLCEAGKCSYLRPQGRNILKTILLDALIRDFQKRK
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Progonadoliberin-2, Progonadoliberin II.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: SIRB_BACSU
Sequence: MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLELQEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKPIGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKEVIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNVYLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH
What is the function of this protein?
Chelates iron to the siroheme precursor.
What are the official names of this protein?
Sirohydrochlorin ferrochelatase.
What is the protein family that this protein belongs to?
Belongs to the CbiX family. SirB subfamily.
Protein: RS14Z_AQUPY
Sequence: MPRKAKVAKDLMYYPKWKSRKKNRCPICGRPRAFIRYFNMCRICFREHALRGDLPGVRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: RPOB_BACCZ
Sequence: MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEGLREMFQDISPIEDFTGNLSLEFIDYSLGEPKYSVDECKERDVTYAAPLRVKVRLINKETGEVKEQDVFMGDFPLMTETGTFVINGAERVIVSQLVRSPSVYYSGKVDKNGKRGFTATVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEITELLGDNEYLSNTLEKDNTDSTEKALLEIYERLRPGEPPTVENAKSLLVSRFFDPKRYDLANVGRYKINKKLHIKNRLFNQRLAETLVDPETGEILAAEGTILDRRTLDRILPYLEKNIGFKTAKPMGGVVEGDVELQSIKIYAPESEGERVINVIGNANITRDVKHITPGDILASISYFFNLLYKVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNAITPQALINIRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSFAKVNEFGFIETPYRRVDPETGLVTGHVDYLTADEEDNYVVAQANMKLSEEGEFLDEDIVARFRGENIVTNKERIDYMDVSPKQVVSAATACIPFLENDDSNRALMGANMQRQAVPLMNPESPIVGTGMEYVSAKDSGAAVICKHPGIVERVEAREVWVRRYVEVDGQTVKGDLDRYKMQKFIRSNQGTCYNQRPIVSVGNEVVKGEILADGPSMELGELALGRNVLVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESEARDTKLGPEEITRDIPNVGEDALRNLDERGIIRVGAEVKDGDLLVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGGGGIILDVKVFNREDGDELPPGVNQLVRAYIVQKRKISEGDKMAGRHGNKGVISRILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVLELHLGMAARYLGIHIATPVFDGAREEDVWGTIEEAGMANDAKTILYDGRTGEPFDNRVSVGVMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTVKSDDVVGRVKTYEAIVKGENVPEPGVPESFKVLIKELQSLGMDVKMMSSDDTEIEMRDTEDDDDHQSADKLNVEVETTKE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: F174B_HUMAN
Sequence: MRAVPLPAPLLPLLLLALLAAPAARASRAESVSAPWPEPERESRPPPGPGPGNTTRFGSGAAGGSGSSSSNSSGDALVTRISILLRDLPTLKAAVIVAFAFTTLLIACLLLRVFRSGKRLKKTRKYDIITTPAERVEMAPLNEEDDEDEDSTVFDIKYR
What is the function of this protein?
Essential for Golgi structural integrity.
What are the official names of this protein?
Membrane protein FAM174B.
What is the protein family that this protein belongs to?
Belongs to the FAM174 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus.