PharMolix/UniProtQA huggingface dataset:
Protein: HNRPC_RAT
Sequence: MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAAEMYGSSFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGFNSKSGQRGSSSKSVKGDDLQAIKKELTQIKQKVDSLLESLEKIEKEQSKQADLSFSSPVEMKNEKSEEEQSSASVKKDETNVKMESEAGADDSAEEGDLLDDDDNEDRGDDQLELKDDEKEPEEGEDDRDSANGEDDS
What is the function of this protein?
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles.  Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.  Single HNRNPC tetramers bind 230-240 nucleotides.  Trimers of HNRNPC tetramers bind 700 nucleotides.  May play a role in the early steps of spliceosome assembly and pre-mRNA splicing.  N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein C, hnRNP C, hnRNP core protein C.
What is the protein family that this protein belongs to?
Belongs to the RRM HNRPC family. RALY subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Component of ribonucleosomes.
Protein: RS21_SHESH
Sequence: MPIIKVRDNEPFDVALRRFKRSCEKAGILADVRAREFYEKPTTARKRAKAAAIKRLAKKLSRENARRVRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RF1_SPHAL
Sequence: MTSVSARQIDAIIERHAALQARMATGDMAPADFVAASKEFAELEPVATAAREVVRLREELVALNEMLADPEMKAMAVEEIAAVEAALPAAEHDLALQLLPKDVADSRAAMLEIRAGTGGDEAALFAGDLLRMYSRYADTQGWKVEIISANEAEVGGYKEVVASVSGQGVFAKLKFESGVHRVQRVPVTESGGRIHTSAATVAVLPEAEEVDVAINDSDLKIDIYRASGAGGQHVNTTDSAIRITHIPTGLVVIQQDQRSQHKNRAKAMQVLRARLYDLEREKLHSAEASARKSMVGSGDRSERIRTYNFPQGRVTDHRINLTLHRLPEILEGAMDELIDALIAEDQAQRLAGLGE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAY_RICPR
Sequence: MNNTAFSKLAETTIVYIVDKIEEQDLEGIIDVDLQGDILNLDTENGIYVINTQSASKEIWLSSPVSGPHHFFYEQGKWKSRIGFELMVLLTEELGIRFDKYEIF
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: TRPC_CAMJD
Sequence: MILDKIFEKTKEDLKERKLKLPYDMLGRSLASNPFFPKDVIKALKRVEKEVKIIAEVKKASPSKGVIREDFDPLSIALNYEKNKAAAISVLTEPHFFKGSLEYLSLIRRYTQIPLLRKDFIFDEYQILEALVYGADFVLLIAKMLSMKELKKLLEFARHLGLEALVEIHDKEDLSKAIFAGADIIGINHRNLEDFTMDMSLCEKLIPKIPNSKIIIAESGLENKEFLEYLQNLGVDAFLIGEYFMREEDEGKALKALL
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: TRHO_PSEA8
Sequence: MTSIVVAALYKFVTLDDYVALREPLLQTLLDNGVKGTLLLAEEGINGTVSGSREGIDALFAWLRSDPRLADIEHKESYCDEQPFYRTKVKLKKEIVTLGVPGVDPNKQVGQYVEAKDWNALISDPEVLLIDTRNDYEVAIGTFEGAVDPKTRSFREFPEYIKAHYDPARHKKVAMFCTGGIRCEKASSYMLGAGFEEVFHLKGGILKYLEEVPQEQSLWRGDCFVFDNRVTVRHDLSEGEYDQCHACRNPVSLEDRQSEHYVPGISCPHCWDSLSEKTRAGARERQKQIELARQRNQPHPLGRDPRQSTLEN
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: RL16_STRCO
Sequence: MLIPRRVKHRKQHHPKRRGMAKGGTQVAFGEYGIQALTPAYVTNRQIEAARIAMTRHIKRGGKVWINIYPDRPLTKKPAETRMGSGKGSPEWWIANVHPGRVMFELSYPNEKIAREALTRAAHKLPMKCRIVKREAGEA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: FLIE_LISMO
Sequence: MAIESINAASVLPKVTLGETAKTDNAAGAGNTFTQMLDSMSDTQSNAQTSVSNLLTTGEGNASDVLIQMKKAESEMKTAAVIRDNVIESYKQLLNMQV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: CARB_LISIN
Sequence: MPKRDDIKTILVIGSGPIVIGQAAEFDYAGTQACLSLKEEGYRVVLVNSNPATIMTDAEMADKVYIEPITLDFVSRIIRKERPDAILPTLGGQTGLNMAMELSAAGILDECNVEVLGTDLTAIKKAEDREAFRDLMNELGEPVPESDIIHNLDEAYTFVERIGYPVIVRPAYTLGGSGGGICHNEQELIETVTSGLKLSPVTQCLLEKSIAGFKEVEYEVMRDANNNAMVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRDVSLKIIRALEIEGGCNVQLALDPDSYNYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEVRNPVTGTTYAHFEPTLDYVVAKIPRFAFDKFEQADRRLGTQMKATGEVMAIGRSWEEALLKAVRSLEIGADHLLLEEAENADAETLERKICFPEDDRLFFLAAALRRGQTIEQLHAKTKIDLFFLYKLSKTIELENRLKENPQNEEILAEAKRAGFSDAFIATCWNIDEQAIYDLRKAQNLFPVYKMVDTCAAEFESTTPYFYSTYEDENESIRSSKESVIVLGSGPIRIGQGVEFDYATVHSVWAIQQAGYEAIIINNNPETVSTDFSISDKLYFEPLTLEDVMHVIEIEQPLGVVVQFGGQTAINLADGLAKRGVKILGTSLEDTDRAENRDAFEKALEILQIPQPAGKTATSVEAAIKVATDIGYPVLVRPSYVLGGRAMEIVESEEALKHYMTNAVKVNPKHPVLVDRYVSGQEVEVDAISDGENVLIPGIMEHIERAGVHSGDSIAVYPAQRLSEQVKNTIVDYTTRLATGLNIIGMLNIQYVVDGEEVFVIEVNPRSSRTAPFLSKITEIPMANVATRVILGENLIDLGYTPGLAPEKQEIFVKVPVFSFAKLRSVDTSLGPEMKSTGEVMGKDVTLEKALYKGFVASGTTMHDYGTVLLTVADRDKEEAVELAKRFNRIGFTIMATKGTASTLEEAEIPVSQVKKIGENQETLIDYIRNGQVTLVVNTLTTGKRPERDGFQIRRESVENGIPVCTSLDTAEAILRVLESRSFELESMNASEVKQPKARV
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: PROA_RHOPS
Sequence: MTASLKANDGSAELAALMTDLGRRARAAARVLALAPPEQKNRALEAMERAIRAGAAAILDANAEDVADAKGSGANSAFLDRLTLTPARVEAMAEGIAVVRGIADPVGAVTESWQRPNGMTIERVRVPLGVVAVIFESRPNVTADAGVLCLKSGNAVILRGGSESFRSGRAIHACLVQGLREAGLPEAAITLVPTRERAAVGLLLGGLNGTVDVIVPRGGKSLVARVESEARVPVFAHLEGINHVYVDRTADLDMAKSIVLNAKMRRTGVCGAAETLLIDRAAADTHLAPLVGMLIDAGCEVRGDDAVQRADARVKPATDQDWDTEYLDAVIAAKVVDDVDDAITHIHEHGSHHTDAIVAEDAKTAAKFLGEVDSAIVLHNASTQFADGGEFGFGAEIGIATGKFHARGPVGAEQLTTFKYRIHGTGQTRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLTF_YERPS
Sequence: MTRIKLSYFTIGLVALLLALALWPNIPWRNGQEGQLDQIKARGELRVSTISSPLIYSTEKDTPSGFDYELAKRFADYLGVKLVIIPHHNIDDLFDALDNDDTDLLAAGLIYNRERLNRARTGPAYYSVSQQLVYRLGSPRPKSFSDLKGQVVVASGSAHMTTLKRLKQTKYPELNWSSSVDKSGKELLEQVAEGKLDYTLGDSATIALLQRIHPQLAVAFDVTDEEPVTWYFKQSDDDSLYAAMLDFYSEMVEDGSLARLEEKYLGHVGSFDYVDTKTFLSAIDNVLPSYQHLFEKHAGDIDWKLLAVIAYQESHWNPQATSPTGVRGLMMLTRVTADGLGVKDRVDPEESIRGGAIYLQRLMKKLPETIPEDERIWFALAAYNLGYGHMLDARRLTKNQNGNPDSWVDVKMRLPMLSQKRYYPSTTYGYARGHEAYNYVENIRRYQVSLVGYLQEKEKKAAQHAAIEAELGKSNPVVGPGWSIGD
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: SPEE_SYNJA
Sequence: MNTPKSFFWAQEYFTPWDYTARAITRILAYRKTRFQEMLIAETGAYGKGLMLDGHWQSTTADEFLYHEALVHPALVQVVQAGGIPRRVLILGGAEGATLREVLRWRSVEQVVMVDIDGEVVEACREHLPEMHQGSFADPRAEVVIADALDFLGQTEPIWDAILSDLSDPVEAGPAYRLFTQEFFRQVRSKLQTAGAFVIQAGPTGPVELWQHTRIVHTLKTVFAAVQPYAIYAPTYGGPLGFALAAQDPISSRPEPEQVDQILAQHLDPDRGALRFIDGITLLGLYQVPAHLRRAIAAETTVYTLANPPQVE
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_RHOPT
Sequence: MTDTIDPDLIERGRKMFAGDWHFIWASPSIETLPPMGSVEIAFAGRSNVGKSSLINALTGRNALARTSHTPGRTQELIFFEGPPNAGLRLVDMPGYGYAAASKAKVASWTSLIHHFLQGRATLARVYVLIDGRHGLKDVDLDILKTLDKAAVSYQIVLTKADQVKAAELAERVTATVAALAKHPAAFPEVLTTSSRTGAGMPELRAAMIRLLDERR
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: UVRB_LACLM
Sequence: MAIERITDNKFELVSKYDPAGDQGQAISELVENIENGEKAQILRGATGTGKTYTMSQVIAQTGKPTLVMAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYQDSVVSLRPGQEISRDQLLNDLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQVLGEVDHLAIFPATHFMTNDDRMEESIAKIEAELEAQLKVFRSEGKLLEAQRLEQRTNYDIEMLREMGYCNGVENYSRHMDGREEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGDRARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSATPGDYEMEQTDTIVEQIIRPTGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKYMHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVILYSDMAKALDENDPADKEILDSGYYTEYEGKKYKITRSMKHAMDETARRRDIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSGELEEVDASAMNKKERKALVKKLEKEMQQAAAALDFEGAAQLRDMVLELRAMD
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_BRUAB
Sequence: MGQKINPIGLRLGINRTWDSRWYANTGEYGKLLHEDVKIREFLTEELKQAAISKIVIERPHKKCRVTIHSARPGIIIGKKGADIEKLRKKLSEMTNADTSLNIVEVRKPEVDATLIAQSIAQQLERRVAFRRAMKRAVQSAMRLGAEGIRINCSGRLGGAEIARMEWYREGRVPLHTLRADIDYGTAEAKTAYGICGVKVWVFKGEILEHDPMASERRAVEGDNQGSSSNRRRENA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: DNLJ_PROMT
Sequence: MNSNFNQHFERIKELRALLNKANYSYYVLDSPEIDDSVYDQLYRELIEIENIHPSLITDDSPSQRLGGVPSKGFKNVEHNIPLLSLDNAFNLNEVEAWYGRISKLISSENKNIKKVYDPELICELKIDGNAISLRYENGILTRATTRGDGKTGEDITTNIRTISTIPLRLLLENPPLWVEIRGEAFMPNNIFNKLNIERKNNDQPLFANPRNSCAGTLRQLDPKIVASRKLDFFAYSLYFPENWEPTDNNFKKPISQSESLEFLKNIGFKVNTTYETTKTLNEANKYYKYWEVKKDFLAYATDGIVVKIDKFEIQNLLGATNKAPRWAIAVKYPAEEKATKLRKIIFQVGRSGAVTPVAEFESIELAGTSVNRATLHNAKRLASLDLHYEDTIIVRKAGEIIPEVIRVIKEFRKVDAKLVQLPQNCPECNSKLILESNEAITKCINYRCAAKLKGLLRHWVSKGSMNIDGLGEKIINQLVNEGYVKSIADLYKLEIDSLLELERFGEKSANNLLIEINESKNKNWHKQLYGLGIPHIGEANAKSLSNNFNSIEELNAIAKESPEKISNIYGFGNEMKDAIVKWFDDSNNQTLIKELKAIGFSLKESLDSNYNSNQSNVFDGKSFVLTGTLDSLTRDEAKELIESAGGKVSSSISKKTDFLVSGEKAGSKLNKAQELGVKIINENELKLLL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: FUS8_GIBM7
Sequence: MESTPLQYPLGLKTDSLVKQVSEVLKSLTVTKAVGAFIVLFIIIPKVFDFLRNLFSPVTSIPGPLINKFSPWPLEIATFKGKSHRFARALHRKYGPIVVLAPGMISIGDSKEIKRIIQSEDWVKSEAIYGNFRQDFHRPTLLAFTEKKAYSRRKRMLSSMFGIRYIRSLEPLMKSCVDAGVAHLNKLCDNPSKSTIINLQHFIHGLAIDTIGVTTFGGSFHVVENGSHPLPSRLKAGMKISAVMQLISWIKYIPFLPKRDPYIEKFTFDIVDKRRKEAGAVKHQDLLQHLVDVCDDSPGSEFRTSDVQDESVILLAAGSETTANAELFTVIQLLKHPEKMKKLIAEVDKWYPPSEPDRATECAYSQTGMTYLQACIDETMRLIPGQATGSPREASKQEVLLGYKIPRGTTVFPNTQEAHLDGSIWEQPEKYIPERWLEIYSRNQTSAMPYWPFSAGSRICVGKNFAFQEMHISLTTLLRKFTFEYVPGQDETTVFRIAQQLEADSYKVRVKKRF
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C (PubMed:17121404, PubMed:22652150).  Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production (By similarity).  The roles of the other FUS members are yet undetermined (By similarity).  The fusarin C synthetase FUS1 is responsible for the condensation of one acetyl-coenzyme A (CoA) unit with six malonyl-CoA units and the amide linkage of the arising heptaketide and homoserine, subsequently releasing the first intermediate, prefusarin, as an alcohol with an open ring structure (PubMed:17121404).  The cytochrome P450 monooxygenase FUS8 participates in multiple oxidation processes at carbon C-20 and is able to use the FUS1 product as substrate, resulting in formation of 20-hydroxy-prefusarin (By similarity).  This reaction seems to be essential before the 2-pyrrolidone ring closure can be catalyzed by FUS2, generating 20-hydroxy-fusarin (By similarity).  FUS8 is able to further oxidizes carbon C-20 after ring closure, resulting in the formation of carboxy-fusarin C (By similarity).  As the last step, FUS9 methylates the hydroxyl group at C-21 to generate fusarin C (By similarity).  Fusarin C can then rearrange to epi-fusarin C, the (z)-isomers, and fusarin A and fusarin D (By similarity).
What are the official names of this protein?
Cytochrome P450 monooxygenase FUS8, Fusarin biosynthesis protein 8.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RIBXA_VIBVY
Sequence: MHFVSYSLCYDVRSNIMEQPIYFYEPDENHGFLANFYPCSITVSGTCWPSSEHYYQAQKFDDVRLQEKVLRAEDAAQAFRLSREYQQWQRHDWYDIRVEVMRFIVREKFLQNTPLAHQLLATGDTELKEHSHKDAFWGDGGDGHGRNELGRILMMVREELQEHAPYNLVQFIDSAKLPTQWGTFQMYGFIEKATGKEHLALVYGDIEQQAAPLIRLHSECLTGDALFSARCDCGFQLAKALQNIVAEGAGVLLYLRQEGRGIGLINKIRAYHLQDDGADTVEANEQLGFGADMRDYAFCRGILSFLGIERVRLMTNNPRKVKALQLANIEVTERVPLQEGNNPHNHQYLRTKADKLGHMFDRNFVKP
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein VVA0006.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: ARP3_BOVIN
Sequence: MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
What is the function of this protein?
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility.  Seems to contact the pointed end of the daughter actin filament.  In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation.  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA.  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).  Plays a role in ciliogenesis.
What are the official names of this protein?
Actin-related protein 3, Actin-2, Actin-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Nucleus. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).
Protein: ATG8A_ORYSJ
Sequence: MARTSFKLEHPLERRQAESARIREKYSDRIPVIVEKADKTDVPEIDKKKYLVPADLTVGQFVYVVRKRIKLSPEKAIFVFVKNTLPPTASLMSAIYEENKDEDGFLYMTYSGENTFGSA
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.
What are the official names of this protein?
Autophagy-related protein 8A, Autophagy-related ubiquitin-like modifier ATG8A.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor. Cytoplasm, cytoskeleton.
Protein: EX7L_SALDC
Sequence: MLSSQTSSIFTVSRLNQTVRLLLEQEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIAESMQPAGEGLLQQKYEQLKAKLQAEGLFDQQHKQPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANARGECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEIVSRNQQELLRQIQSAQQRLGMAMDYYLANRSRRFTQIFHRLQQQHPQLRLARQQTALERLRQRMGFALEARIKQANQRQQRVSQRLSQQNPQPRIHRAQSRIQQLEYRLTENIRSRLSEQRERFGNAVTHLEAVSPLATLARGYTVSTTTDGKVLKKIKQVKAGDIMTTRLEDGWLESEVKSVTPGT
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX3_DANRE
Sequence: MAHQAHAYHMVDPSPWPLTGAVAALLMSSGLAIWFHLHSMTLIVLGMILLILTMIQWWRDIIREGTFQGHHTPPVQKGLRYGMILFITSEVFFFLGFFWAFYHSSLAPTPELGGCWPPTGLTTLDPFEVPLLNTAVLLASGVTVTWAHHSLMEGERKQAIQSLALTILLGLYFTALQAMEYYEAPFTIADGVYGSTFFVATGFHGLHVIIGSTFLAVCLLRQVLFHFTSDHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YL12_ADE41
Sequence: MTESIMEGFLNLAQRLGIGKEALQALELNGNQNDRHHHFAPFLQSGGVMAVKPACKIVVRNHGLAILGVLFGLI
What are the official names of this protein?
Uncharacterized 8.0 kDa protein in 100 kDa protein region.
Protein: ALFL3_ORYSI
Sequence: MEMAPAAQVASNPRTVEDIFKDYSARRGALVRALTSDVDEFFGLCDPDKENLCLYGLANGSWEVALPAEEVPPELPEPALGINFARDGMNRRDWLSLVAVHSDSWLVSVAFFFAARLNGNERKRLFNMINDLPTVYEALVDRKHVRDRSGVDSSGKSKHSTKRTGEGQVKRSRVVAEEYEDDDEEHNETFCGTCGGLYNANEFWIGCDICERWFHGKCVRITPAKAEHIKHYKCPDCSSSSSKKTRL
What is the function of this protein?
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
What are the official names of this protein?
PHD finger protein ALFIN-LIKE 3.
What is the protein family that this protein belongs to?
Belongs to the Alfin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y5000_DICDI
Sequence: MTLDRDLFYFYLTPEEMNAARAYLYSSSTSSIEISNNSKSNNCCNNSSIPSTPNTPITPLKNNNITIVNNKTNDNKINDDKINDNKISDDKNNDDRIVLFEETFFSQLIPSSNSSSIPILETFMNDEEFEFTFDESKPFCPTNSYCTLNQQNNNSQFFTVPSQYVTKSVSIPSHFINNTPISLSNNNNNNNNNNIINNNINKNNNNNSKGFKNILILRKIFTLKKKKKK
What are the official names of this protein?
Uncharacterized protein DDB_G0282865.
Protein: TM184_YEAST
Sequence: MENKLLCWWLYWPCVYSSIIATIISFYTITRHLLNYRKPYEQRLSIRILLLVPIFSVSCASGIIKPEAAQFYVDPIREFYEAFVIYTFFTFLTLLLGGERNIITVLSLNHAPTRHPIPLIGKICKPIDLSDPFDFLFVKKGILQYVWFKPFYCFGTLICSAWKLPKFEIFLNVFYNISVTWSLYSLALFWKCLYPELTPYKPWLKFLCVKLIIFASYWQSIIIQGLVVTGKLGTGNQDRTSGYVYKNGLLCIEMVPFAILHAVAFPWNKYTAFSIPYGARMKFIYALKDFLGCGDLIWDFKQTLFAGPLYYNYRNFDPEAMDLLSTRQQSGATMERLKHGLRFTDNGRNSYWVAYGSIDNNLVPESIEESWEDDIAGQRTFPEDPNYPVVHDYTMGHRYSRSMNDLRRDVQSRSSMAC
What are the official names of this protein?
Transmembrane protein 184 homolog YKR051W.
What is the protein family that this protein belongs to?
Belongs to the TMEM184 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.