PharMolix/UniProtQA huggingface dataset:
Protein: RR3_EUGGR
Sequence: MGQKVHPLGFRLGITKSHSSFWYVERRHYASFVKEDIVIRNFMNKELLETLISLIKIERIYEFSEQRNNTIVYIHVARPERVIGRDGQGLSRIRDILIDRMNYLLGKTPRIITCKVVGVTSPNLDARLLADSVRRELEKRTPFIRAMKTVMLQAMKAGAEGIKVQVSGRLNGIEIARTEWFREGRVPLHTLRADIDYFNDIAHTIYGVLGIKVWVYKV
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CITD1_SALTY
Sequence: MKINQLAVAGTLESGDVMIRIAPLDTQDIDLQINSSVEKQFGEAIRATILEVLSRYDVRGVQLNVDDKGALDCILRARLETLLARASGIAALPWEDRQ
What is the function of this protein?
Covalent carrier of the coenzyme of citrate lyase.
What are the official names of this protein?
Citrate lyase acyl carrier protein 1, Citrate lyase gamma chain 1.
What is the protein family that this protein belongs to?
Belongs to the CitD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_BACCQ
Sequence: MQKVTIQEAEHLLQEIMSEEDDRFQILIKDERKGVQKLISKWYKQKELAQKEKEKFLEMSKYENALREKGLTYIAGIDEVGRGPLAGPVVTAAVVLPEDFYIPGLNDSKKLSEAKRERFYDEIKAQAIAIGVGIVSPQVIDEINIYQATKQAMLDAVANLSCTPQYLLIDAMKLPTPIPQTSIIKGDAKSISISAASIIAKVTRDRMMKELGEKYPAYGFEQHMGYGTKQHLEAIEAHGILEEHRKSFAPIKDMIQK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_SHISS
Sequence: MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERLYRSGLASLHARVKVRITEYEKDANGELVAKTSLKDTTVGRAILWMIVPKGLPYSIVNQALGKKAISKMLNTCYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPEKKHEIISEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKAMMDNLQTETVINRDGQEEKQVSFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHEGIMMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADILVPRNTLLHEQWCDLLEENSVDAVKVRSVVSCDTDFGVCAHCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSIKLSNVKSVVNSSGKLVITSRNTELKLIDEFGRTKESYKVPYGAVLAKGDGEQVAGGETVANWDPHTMPVITEVSGFVRFTDMIDGQTITRQTDELTGLSSLVVLDSAERTAGGKDLRPALKIVDAQGNDVLIPGTDMPAQYFLPGKAIVQLEDGVQISSGDTLARIPQESGGTKDITGGLPRVADLFEARRPKEPAILAEISGIVSFGKETKGKRRLVITPVDGSDPYEEMIPKWRQLNVFEGERVERGDVISDGPEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKATIVNAGSSDFLEGEQVEYSRVKIANRELEANGKVGATYSRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAAGEAPAAPQVTAEDASASLAELLNAGLGGSDNE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: NT2NB_HUMAN
Sequence: MPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGICLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWERDREVWNGKEHDEN
What is the function of this protein?
Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261).  Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955).  Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955).  Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954).  Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955).
What are the official names of this protein?
Notch homolog 2 N-terminal-like protein B.
What is the protein family that this protein belongs to?
Belongs to the NOTCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: PXPA_HALH5
Sequence: MQRVDLNSDLGESFGAYTIGQDDRVLEHVTSANIACGYHAGDHNVMARTVKLAADKGMGIGAHPGFPDLLGFGRRNIQTDHKDIYNFIVYQVAALNGFCQLHRVRMQHVKPHGALYNMAAKDRVIAEAIAEAIYDIDPSLILFGLSGSELIKAGKKLGLTVANEVFADRTYQPDGTLTPRSEANALIKESERATEQVIQMVKESKVIAVDGSHIPIEADTICVHGDSPTALSFIERLHAQLQVEGVTVTKVSDFLFK
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: DASA_STRCO
Sequence: MKRKLIAAIGIAGMMVSIAACGGDSDDDGKKAGADGYAGETLTVWVMDGSSPDDWQADLAKDFEAKTKAKVKFEIQKWNGIQQKLTTALSEENPPDVFEIGNTQTPAYAKTGGLADLSDLKGEIGTDWSESLNKSAVFDGKQYAAPWFVVNRVVVYNKKIWADAGIKELPKTRDEFYNDLKTIGEKTDAEPIYLPGQNWYHFVGLVIGEGGELVKKDGDKYVSNLADPKVAAATETYKKFQALSKAPKDKDEATPQQGEIFAKGKTGSFIGMGWEGATAIATNPAIEKDLGYFTIPGPTADKPEGVFLGGSNLAVAAGSKKQDLAKEFLKLALSDKYEGGLAKANGVIPNKEALQSNLKGNAAAEAAAPAAGTGDTTPLIPEWAAVENDPNPIKTYLTAVMKGKSPADAAKQVEGEFNKRLAQQQ
What is the function of this protein?
Part of the ABC transporter complex DasABC-MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake.  Binds specifically to (GlcNAc)2.  Can also bind to GlcNAc, (GlcNAc)3, (GlcNAc)4 and (GlcNAc)5, but it exhibits the highest affinity for (GlcNAc)2 (PubMed:17351098).  Involved in the control of morphological differentiation (PubMed:18227241).
What are the official names of this protein?
Diacetylchitobiose binding protein DasA.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: OEP24_PEA
Sequence: MKAALKGKYDLDHNSSGAATVAFNAGDVKLRASITDATFKNSPSLTGLVLAVEKPGSFSVDYNVPKKDFRFQFMNTVRVAEKPLNLAYIHSKGDNRTILDGTLVWDPSNKVSANYAVESGNCKLKYSYNHKGLTTIEPTYDVAKNSWDFAVSGKVYGDDSLKASYQTSSKVLGLEWTRNSKQTGCFKVVASVNLAEEKKIPKLSVESTLNFEM
What is the function of this protein?
High-conductance voltage-dependent solute channel with a slight selectivity for cations transporting triosephosphates, dicarboxylic acids, ATP, inorganic phosphate (Pi), sugars, and positively or negatively charged amino acids.
What are the official names of this protein?
Outer envelope pore protein 24, chloroplastic, Chloroplastic outer envelope pore protein of 24 kDa.
What is the protein family that this protein belongs to?
Belongs to the plastid outer envelope porin OEP24 (TC 1.B.28) family.
What are the subcellular locations of this protein?
Plastid, etioplast membrane; Multi-pass membrane protein. Plastid, chloroplast outer membrane; Multi-pass membrane protein. Note=Present in non-green root plastids.
Protein: NQRA_PSYIN
Sequence: MITIKKGLDLPIAGTPEQVIHDGPSITEIAILGEEYVGMRPFMAVKVGDIVKKGQILFSDKRNSGVHFTSPASGTVKAINRGAQRVLQSVVIAIEGKESISFPKYTSTELKNVGRAEIVKNLIDSGAWTALRTRPFSKIPAVDAEPVSIFVTAMDTNPLAADAELIINTNKQAFTDGLALLEQLTAGKVYVCKGETNLPKSESVNVEEKLFSGVHPAGLAGTHIHFIDPVSAVKQVWSINYQDVIAFGMLFTTGELYTNKVISLAGPAVKKPRLLRTHYGASINQLTKNELIDDEVRVISGSVLCGVTATAAHAYLGRYHNQISVLAEGYEKELFGWGVPGSKKHSVSNAFISAFNRAKSFAFTTTTGGSKRAMVPIGQYERIMPLDILPTNLLRDLIVGDTEEAQALGCLELDEEDLALCTYVCPGKYDYGSVLRASLSKIEKEG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit A, Na(+)-NQR subunit A, Na(+)-translocating NQR subunit A, NQR complex subunit A, NQR-1 subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrA family.
Protein: PFL6_SCHPO
Sequence: MNFFLYFRTIFLIQLYFFNYSTFGCSASSTSVQSDTTNQVSVSCPKYTTIYTSGTSPDTKTIYPESTSTKSITTSTQSHSSPVIVVSTVGTVTETTISGSTEYTTTIPAEGITSGTVEIVEPTAGTVTETITSGTLPFTTTLAQASGTVSGTVEIVSPKNNPTTVYSGTVATTETFSSSTVVVIPTAICDGVRGLEYAVYDYTISSSMNEFCYPKNGQTDVFAFNEPAYFGSSDLDQSSPLFTGVFSSTDDIPEWASSWYLPPYPPQASDMASTYCACKVIVYQFFLRIPETDTYTLVVNNVDDVFFGWFGDKAISGWSNNNFDAYSYWHESPNMGLGTVGMGNFTVGNYPEGYFLPVRFVVANGAYIGGFDFYFTSDSTGPLATTSYSYTKTCTQQFLPFGQGNGGVNGPTEKLS
What is the function of this protein?
May be involved in agglutination during conjugation or other aspects of colony formation (By similarity).  Induces flocculation when overexpressed (PubMed:23236291).
What are the official names of this protein?
Putative cell agglutination protein pfl6, Adhesin pfl6, Pombe flocculin 6.
What is the protein family that this protein belongs to?
Belongs to the mam3/map4 family.
What are the subcellular locations of this protein?
Cell surface.
Protein: RTL6_HUMAN
Sequence: MVQPQTSKAESPALAASPNAQMDDVIDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISSITSNGTRPMTTPPTSLPEPFSGDPGRLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKSPLRHARRAQIRKTSASNRAVRERQMLCRQLASAGTGPCPVHPASNGTSPAPALPARARNL
What are the official names of this protein?
Retrotransposon Gag-like protein 6, Leucine zipper protein down-regulated in cancer cells-like, Mammalian retrotransposon-derived protein 6, Protein LDOC1L.
What is the protein family that this protein belongs to?
Belongs to the LDOC1 family.
Protein: SUGP1_ARATH
Sequence: MDKGAPPSIFVNDGSFMERFRQLQQEKDKDKDKVVQVEDSKPVKIISNPKPAANKISIGLKPNDAQKKGGKLAFSLKQKSKLLAPPVKLGTEEDEDDEDVKHEQGFGSVKRQKLEQRDTPVKSAKVSDVAPPPPSDPTVKKVADKLASFVAKHGRPFEHITRQKNPGDTPFKFLFDENCADYKYYVFRLAEEEKLISQTKDSGVLHSGDAGSRTSTAAIPLQKPAYQQTGYQIPASALYDTPVEPGASSRSAQASITRPSDSDSFSGPRGADPLSMMEFYMKKAAQEEKMRRPRQSKDEMPPPASLQGPSETSSTDPGKRGHHMGDYIPLEELDKFLSKCNDAAAQKATKEAAEKAKIQADNVGHKLLSKMGWKEGEGIGSSRKGMADPIMAGDVKTNNLGVGASAPGEVKPEDDIYEQYKKRMMLGYKHRPNPLGNPRKAYY
What are the official names of this protein?
SURP and G-patch domain-containing protein 1-like protein, Splicing factor 4-like protein, SF4-like protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNRD_STRPE
Sequence: MSTQIDLVRRMVEAYNTGKTDDVAEFIHLEYLNPGALEHNPELRGPEAFAAAVTWLKYAFSEEAHLEEIEYEENGPWVRAKLALYGRHVGNLVGMPATGRRFSGEQIHLIRIVDGKIRDHRDWPDYLGTYRQLGEPWPTPEGWRP
What is the function of this protein?
Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin).  These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers.  Catalyzes the cyclization of aklanonic acid methyl ester to yield aklaviketone presumably via an intramolecular aldol condensation mechanism, although water is not eliminated.
What are the official names of this protein?
Aklanonic acid methyl ester cyclase DnrD, AAME cyclase, Methyl aklanonate cyclase.
What is the protein family that this protein belongs to?
Belongs to the polyketide cyclase DnrD family.
Protein: AROL_ECO45
Sequence: MTQPLFLIGPRGCGKTTVGMALADSLNRRFVDTDLWLQSQLNMTVAEIVEREEWAGFRARETAALEAVTAPSTVIATGGGIILTEFNRHFMQNNGIVVYLCAPVSVLVNRLQAAPEEDLRPTLTGKPLSEEVQEVLEERDALYREVAHIIIDATNEPSQVISEIRSALAQTINC
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_POLAQ
Sequence: MNEITDKNLPTLERATLGGGCFWCLEAVYQQIQGVKSVVSGYAGGARPNPSYESVCTGATGHAEIVDIEFDPKVVSFRDLLEIFFVIHNPTTLNYQGNDHGTQYRSVIYTHSDEQAKIANEVVQELEDSKIYADPVVTQIESAPTIYPAEDYHQNYFQQHPHQGYCAAVVAPKLAKFRAKFKSLIAPQYA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: TRHO_SALAR
Sequence: MPVLHNRISNDELKARMLAESEPRTTISFYKYFTIVSPQQTRDALYQMFTALGIFGRVYLAHEGINAQISVPQSKVETFRQQLYAFDPALDGLRLNIALEDDGKSFWVLRMKVRDRIVADGIDDPSFDASNVGAYLKAAEVNAMLDDPDAIFIDMRNHYEYEVGHFENALEIPADTFREQLPKAVEMLREHADKKIVMYCTGGIRCEKASAWMKHNGFNKVWHIEGGIIEYARRAREQGLPVRFIGKNFVFDERMGERISDEVIAHCHQCGALCDSHTNCKNAGCHLLFIQCPLCASKFNGCCSEQCCEELALPEDEQRRRRAGREKGNKIFNKSRGRLNSKLGIPDPTE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: RL1_DICTD
Sequence: MAKRGKRYQQLLSLIEKGRLYSPKEAVSLVKKLATAKFDETINLAVRLGVDPRHADQQVRGTVVLPYGTGKEKKVLVFAEGEKAQEAREAGADYVGGEDLVKQIESGWLDFDVAIATPDIMGTLKIPSRLGKILGPRGLMPNPKTGTVTNDIAKAVKEYKAGRVEFRTDRYGIVHVPIGKASFSEEALYKNLMTVLGTLLRLKPAAAKGQYFKSIYISPSMGPSVPIDTKNIADLVKQEEAA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: EI3G1_DROPE
Sequence: MPGVETIKSSWADEVELDYGGLPPTTENVENGHKYVTEYKYNKDDKKTKVVRTYKISKQVVPKTVAKRRTWTKFGESKSDKPGPNSHTTMVSEEIIMQFLNSKEDEKANDPLLDPTKNIAKCRICNGEHWSVNCPYKGTAMDTNLMEKKAAAAASAAVDAPKSGKYVPPFLKDSQKGGLGMRGRDDTAAIRISNLSESMTEADLEELVKKIGPQSKMYLARDKNTGLCKGFAYVHFKQRKDAAAAIEILNGHGYDHLILSVEWSKPQNN
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  This subunit can bind 18S rRNA.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit G-1, Eukaryotic translation initiation factor 3 RNA-binding subunit 1, eIF-3 RNA-binding subunit 1, Eukaryotic translation initiation factor 3 subunit 4-1.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit G family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AKT41_ALTAL
Sequence: MSFCDDREGQRALRILQARLIRSPDACSFALTAVSSLLRKYSIDPRRIGRLEVGTESLVDKSKSIKSFVMQLFEESGNFDIEGVDTVNACYGGTNALFNAVNWVESSAWDGRDAIVVASDISLYGKGNARPTGGAGCVAMLVGPDAPIAFEPGRRGSYMAHTYDFYKPDFTTEYPYINGKHSIECYIQAVEACYRAYTKRERRATERLEEERPDHQAGYETPLDRFDYLCFHSPTNKLVSKSYARLLYVDYLENPANPIFAEVPDSIREVEYRASLTDKSIEKTFMGLAQERFARCVQPSTEIPNMCGNMYSASVYGSLCSLLCNVNSETLLGKRITIFSYGSGLASSMFSLKVRGSTKQMAEKLDVHRRLVDRVVVSPEDVRERAYLKKCFKPKGGAGPIPADVYSLAEVDELFRRVYTVKS
What is the function of this protein?
Hydroxymethylglutaryl-CoA synthase-like protein; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) AK-toxins responsible for Japanese pear black spot disease by the Japanese pear pathotype (PubMed:24611558).  AK-toxins are esters of 9,10-epoxy 8-hydroxy 9-methyldecatrienoic acid (EDA) (PubMed:22846083).  On cellular level, AK-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).  The acyl-CoA ligase AKT1, the hydrolase AKT2 and enoyl-CoA hydratase AKT3 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) structural moiety (PubMed:10432635, PubMed:10975654, PubMed:22846083).  Part of the EDA biosynthesis occurs in the peroxisome since these 3 enzymes are localized in peroxisomes (PubMed:20348386).  The exact roles of the 3 enzymes, as well as of additional AK-toxin clusters enzymes, including AKT4, AKT6 and AKTS1, have still to be elucidated (PubMed:10432635, PubMed:10975654, PubMed:22846083).  The Cytochrome P450 monooxygenase AKT7 on the other side functions to limit production of EDA and AK-toxin, probably via the catalysis of a side reaction of EDA or its precursor (PubMed:24611558).
What are the official names of this protein?
Hydroxymethylglutaryl-CoA synthase-like protein AKT4-1, AK-toxin biosynthesis protein 4-1.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
Protein: CG121_CANAL
Sequence: MTSEVIKFPQFPEFTIHISLFINVSSENITTIKSNLISATDNDHNKYDYCFLNTKYIISKEHLFQSIYKSLLNYTSKLGLSTRNLKSEIIYNLSPINNVGDALKRFGISEDCPNCIVIKIINNNNKENSEETKISEKVTTDLKEIIDGELIELNDQYIFENFIDLAKFRKLYKLNDVVDLNKEDNLQGRLTRLAIGACILRGY
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.  CGI121 is not required for tRNA modification (By similarity).
What are the official names of this protein?
EKC/KEOPS complex subunit CGI121.
What is the protein family that this protein belongs to?
Belongs to the CGI121/TPRKB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: RSME_HELPJ
Sequence: MRFVYHPLAKEPTLKIEGESYIHLYRSRRIKSASRLDLRNLKDGFLYTYEHAEIAKKHALLRLVGVQPLEIMANKKTHLILSVIEIKNIEKILPFLNQLGVSKLSLFYADFSQRNEKIDSAKLERFQKILIHSCEQCGRSVLMELEAFSNTKEALKAYPKASVLDFNGETLPASADFEKGVIIGPEGGFSEQERGYFKEREIYRIPLDMVLKSESACVFVASIAQI
What is the function of this protein?
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA.  Acts on the fully assembled 30S ribosomal subunit (By similarity).
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase E, 16S rRNA m3U1498 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RsmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRP36_PARBP
Sequence: MPILSKLNKRVRARVEEDDFEHFSQESASDGSELGEEDEEETDDSDGSTSESDDGSGRDGDESENEDLESDSASDANSDITSSLNNISFGALAKAQASLGKRKRSTTLTADIASKRPKGPSRSPPAPSSKEDQKYPNATKPPQKLSHRTSKHAPTIQSSRHAVTRKRTVIENPAIPQARDPRFDSVVLNHSTNGNPSIATNATIHASKNYAFLNSYRTEELSQLRKRLQNLQREKSKDTHDEREIERLKRQITSMSDRMRTFERKEMEREVLAGHRRKEREAIREGKKSQPWFLKKGDVKREVVTRRFTEMSGKEKQRALERRRKKIASKEKKEMPWARRGVE
What is the function of this protein?
Component of the 90S pre-ribosome involved in the maturation of rRNAs.  Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
What are the official names of this protein?
rRNA biogenesis protein RRP36, Ribosomal RNA-processing protein 36.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SYI_XANC8
Sequence: MTQDYKATLHLPATDFPMRGDLPKREPAMLERWEREGLYAQVRANAAGRPLFVLHDGPPYANGQIHLGHAVNKILKDIIVKSKYLAGFDAPYIPGWDCHGLPIEIAIEKKFGKVGVKLDAAQFRQKCREYATEQIDLQRRDFKRLGVIGDWDNPYKTLDFRFEANEIRALAKVIDNGHLTRGVKPVHWCFDCGSALAEAEIEYADKLSPTVDIAYPARDPAAIAAAFGVTLPAGTQVAVPIWTTTPWTLPASLAVSLGAELDYVLVEGPADRGQPRWLVIAEALAGKALARYGVEAVVVHGHAKGAALDQLLLAHPFYAERDIPLILGDHVSDDDGTGAVHTAPGHGQEDYQVSKQYGLLERYSAAQINPIDGRGVYLPSTPPLGDTVLAGLHIWKANDVIIDALRDTGVLLAASTMEHSYPHCWRHKTPIAFRATPQWFISMEQANLRADALKAIETVHWYPSWGQARIAGMIDGRPDWTISRQRTWGVPIALFVHRETGEPHPRSTELMRQVAERVEQGGVDVWYTLDAAELLGDEAGDYDKITDILDVWFDSGVTHEAVLVDRGLPKPADLYLEGSDQHRGWFQSSLLTGVAMDKVAPYKQCLTHGFTVDEHGRKMSKSLGNGIEPQEIMRTLGADILRLWIASADYSNEMSLSQEILKRNADAYRRLRNTARFLLGNLHGFDPLQHLVALDDMVLLDRWIVHRAHELQEKITAAYARYDFAEIVQALLNFCSVDLGSLYLDVTKDRLYTMAEDARGRRSAQSAMYHVAEAFVRWIAPVLSFTAEELWAYLPGEHSGNVLFATWYDGLAPMPADAALTSADVDKLLALREQVAKVLEPMRANGAIGAALEAEITVAADAQTAARWQPLSDELRFLFISGDVTVTAASTDDIFVSAQPTTKAKCVRCWHHQASVGSDPRHPELCSRCVSNIEGPGEERRWF
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBE2T_HUMAN
Sequence: MQRASRLKRELHMLATEPPPGITCWQDKDQMDDLRAQILGGANTPYEKGVFKLEVIIPERYPFEPPQIRFLTPIYHPNIDSAGRICLDVLKLPPKGAWRPSLNIATVLTSIQLLMSEPNPDDPLMADISSEFKYNKPAFLKNARQWTEKHARQKQKADEEEMLDNLPEAGDSRVHNSTQKRKASQLVGIEKKFHPDV
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  Catalyzes monoubiquitination.  Involved in mitomycin-C (MMC)-induced DNA repair.  Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106).  Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784).  May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602).  In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 T, Cell proliferation-inducing gene 50 protein, E2 ubiquitin-conjugating enzyme T, Ubiquitin carrier protein T, Ubiquitin-protein ligase T.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates to chromatin.