PharMolix/UniProtQA huggingface dataset:
Protein: 3S11_MICSU
Sequence: MICYNQQSTEPPTTKTCSEGQCYKKTWSDHRGTIIERGCACPNVKPGVKISCCSSDKCR
What is the function of this protein?
Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.  Binds to and inhibits the endogenous nicotinic acetylcholine receptors (nAChR) in human rhabdomyosarcoma TE 671 cell line with an IC(50) of 48. 2 mM.  This neurotoxin is lethal to mice by intraperitoneal injection and to zebrafish by injection at the back of the dorsolateral region.
What are the official names of this protein?
Three-finger toxin MS1, Short neurotoxin MS1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: OADC1_PSEPF
Sequence: MTRLSHQDLRRNFRQLLASDTCYHTASVFDPMSARIAADLGFEVGILGGSVASLQVLGAPDFALITLSEFAEQATRIGRVAQLPVIADADHGYGNALNVMRTIVELERAGVAALTIEDTLLPAQFGRKSTDLITVAEGVGKIRAALEARVDSEMAIIARTNAGILPNQEIISRTKQYQAAGADGICMVGIQDFDQLEQIAEHLTVPLMLVTYGNPALRDDKRLAELGVRVTIDGHGAYFAAIKATYDSLREQRQIFTQASDLSATELTHTYTQPEEYILWAKEYMSVKE
What is the function of this protein?
Catalyzes the decarboxylation of oxaloacetate into pyruvate.  Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate.
What are the official names of this protein?
Oxaloacetate decarboxylase 1.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family.
Protein: HSRA_HAEIN
Sequence: MTTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGALGILASGSVMNNIKGKAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVTYCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNLYRHFFSASDCLPQAFSYTFLTSSLFVIALVWSLMKLHKHDGDHLRKMP
What are the official names of this protein?
Probable transport protein HsrA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EmrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS19_VESOH
Sequence: MARSLRKGPFVDEHLIKKVLAAQGNNDRKPIKTWSRRSVVVPEMIGLTIAVHNGRVHVPVSINENMVGHKLGEFAITRTFKGHFGDRKA
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: Y1752_ERWT9
Sequence: MKTMQQRLAQATLPLVVLAALFTATHSAHAQTDRLIIENGDSALTKEQAREQKEQWDATHRLRGKVNNRVEKEFDKADRAYDNQDNCEQSLNVNAYWEPNTLRCLDRRTGRPVTP
What are the official names of this protein?
UPF0482 protein ETA_17520.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: EFP_STRPQ
Sequence: MIEASKLKAGMTFEAEGKLIRVLEASHHKPGKGNTIMRMKLRDVRTGSTFDTTYRPDEKFEQAIIETVPAQYLYKMDDTAYFMNTDTYDQYEIPVANVEQELLYILENSDVKIQFYGSEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATLETGLVVNVPDFIEAGQKLIINTAEGTYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE3_BURP6
Sequence: MKLTPREKDKLLIFTAALLAERRRARGLKLNYPETVAFITAALMEAARDGRTVAEVMHYGTTLLTRDDVMEGVPEMIPDIQVEATFPDGTKLVTVHHPIP
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_AQUAE
Sequence: MQRRPILVVNFGSQYVQLIARRVRELGVYSEIVHWDTPVEEIKKKNPYGIIFSGGPASVYAEGAPLPDKRIYELGVPILGICYGLQVITHQLGGKVVRSEKQEYGRARLRIIKEDVIFEGIPKESDVWMSHADKVVELPEGFEVLAVSENSPYAVIANREKKIYGFQFHPEVTHTVFGKEMLANFIYGVCKAEKNWEMGDFIHEKIEEIRKTVGDAKVIAALSGGVDSTVAAVLTHRAIGDKLHCFFIDHGLLRYKEREEVEKNLRSLGLPLTVVDASEEFLEKLKGVEDPEEKRKIIGRTFIEVFEREAKKIEGAEFLLQGTLYPDVVESAGIKGSAKIKTHHNVGGLPERMNLKLLEPFRELFKDEVRKIGKLLGVPEEILRRHPFPGPGLAIRIIGEVNKKDLEILRKADYIFIQELKKEGLYDRVWQAFAVLLPVKSVGVMGDVRTYEKVVALRAVESVDGMTADWARLPYDFLDRVMRRIINEVEGVNRVVYDISSKPPSTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: ISPF_VIBVY
Sequence: MIRIGHGFDVHKFGGEGPVIIGGVAVPYEQGLIAHSDGDVALHALSDALLGAIAAGDIGRHFPDTDDKWKGADSRELLKDVYRRVKEQGYKLGNADVTIIAQAPKMAPYIDAMREAIAHDLETDIRNINVKATTTERLGFTGRKEGIATEAVVLLIKQ
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: PANC_CLOBM
Sequence: MNIVHTIKDVKSIIKKWKDENLSIGYVPTMGYLHEGHASLIKKAREENDKVIVSIFVNPIQFGPKEDYSTYPRDLDKDSSLCEKFGADLVFNPETSEMYPNKIYSHVNVDILTENLCGEKRPVHFQGVCTVLTKFFNILNPTKAYFGEKDAQQLTVVKKMVEDLNFPIEIIGCPIIREEDGLAKSSRNAYLNKQERKSALILNKSLKEALKSLKSGEKDLNIIKNIIINTIMKEPLAKIDYISIVDSTTLQPVEKLQSSILIAIAVYIGKTRLIDNFTFKL
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF396_IIV6
Sequence: MFKFNIDNPLHKLHKIQSKVSEINTEGGSGGGDGVDEIKTINPATETSLGVVQLSGVLKGTATNPELSFNCVKSNHLSEECVQYNHIQKLSKASLLGQTTKSGGNITEVELNSGLILENGKLSLDLPSIITLSDVMATKSELGVITLGDGGDLNGSPNVNLLENGKISNDPVIGLNKVTYPKIQKVTGKSLLGNSSIFDDNVEEIKIKNGLVLEDSSLSLDVNTLPQASSTTFGVIKLSGDLSGNASSPTIKNQSITSYKLAPLPKHTILGSLDNTLSPTPISLHKSLGVVNEQLKVNPKEIQSTTDSLGTIMLSGDLTGTATNPEISEKSITYSKMQSVNGTKVLLGNLSGTGNISEIEVGDSLILKNGFLDVDLDKLHEESILKVESGGTGNSVLPLGYLKGKEKDPVESVQKIPVTDIFPNVVGSVNGVFPSKPGGNISLIFSNVTTGILSEIPSRQVNGTIYIISGDPTPTNNGRTFISDGTNWNEVTNHLGSTDARYVQLAGSTMSEDASLVFPSTSNIILNQTSFSNKDAVTKEYVDEIKINDATVSSKGILELSGDFDSLSTADNPIIKSATPTVKGKIQLAGDFDPLSTSSLPLIKAASTTSRGKIQLSGDFDPLSTSTNPIIKSATVHSEGKIQLSGDFDSKSTSQFPLIKEASEVHFGKIKLAGDLSGNADAPEIAHNAITYSKIQQASQKSIIGNAINGATDIGEVVIGNGLMLSSGGSLPTVGTLSVDSNTLPKATLNSYGSIQLNGDFNPLSTATAPMIGEGKITYKKMQQISSQRKLLGSASLPIGIQPIQEISVGPSLTYSGAGNNILNASTSFFSGTNPNTSPPTDRPTTSNLLYIGVDGSVWMWNGVHYSKGPGALNVLKSKNLYTIGPLGTPSPLSMSDFDIKVSAGQRIKIKYILNFQSTGGAEYAPSFGWNGVAQEDFFQASIIGFFSSSNTSSSFSTIYQTNTSFTSSSRQVTGGANLFALTSTNADNNLLAWNVGTPEQQLGGIGGQAIPIYITAYYENNTNKETILEIVFNRDLKTQTGQTIQIAGGVADYVTY
What are the official names of this protein?
Uncharacterized protein 396L.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 261R/396L/443R family.
Protein: PLSX_PELUB
Sequence: MSKIIKIAVDAMGGDNSPKKIIDGINHHYKSNTNTFYQIFGDKEKIQNYINQLPTSSFEIIHTKDLVKGTDSPLEGAKRGKNTSMWLAIQSVKEKKSDIVISAGNTGALLVISKLNLKMIENIDKPALSALWPNKKNMSVVLDLGANIECSPKNLIDFSIMGSSLFKSLYPDDTAKVALLNIGSEEIKGNETIKETYQQLNQRNNTDFEFKGYIEGNQLMNGDVNVIVADGFTGNIALKTAEGTANFITSELKKAMTGNIVGKISSLLNISNLKKFKERLDPRLYNGAIFIGLDSPVIKSHGGTDYIGFSNSLSVCTRIVTGNLIEKIRNNIC
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ILVC_GLUDA
Sequence: MRVYYDRDADVNLIKSKKVAIIGYGSQGHAHANNLKDSGVTDMVIGLRPGSSAVAKAEAAGFKVMGPSEAAAWADVVMVLTPDEGQGALYKEHLEANLKQGAALAFAHGLSIHFRIIEARPDLDVFLIAPKGPGHTVRSEYQRGGGVPSLVAVAQNASGNALEIALSYASANGGGRAGIIETSFKEEVETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHETKLIVDLIYEGGIANMNYSISNTAEYGEYATGPRIVTPETKAEMKRVLTDIQDGTFVRNFILENQSGNVGFKAIRARNNAHQIEQVGEKLRGMMPWIGKNKLVDKTRN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: MURQ_SHISS
Sequence: MQLEKMITEGSNTASAEIDRVSTLEMCRIINDEDKTVPLAVERVLPDIAAAIDVIHAQVSGGGRLIYLGAGTSGRLGILDASECPPTYGVKPGLVVGLIAGGEYAIQHAVEGTEDSREGGINDLKNINLTAQDVVVGIAASGRTPYVIAGLEYARQLGCRTVGISCNPGSAVSTTAEFAITPIVGAEVVTGSSRMKAGTAQKLVLNMLSTGLMIKSGKVFGNLMVDVVATNEKLHVRQVNIVKNATGCNAEQAEAALIACERNCKTAIVMVLKNLDAAEAKKRLDQHGGFIRQVLDKE
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: B2L11_HUMAN
Sequence: MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH
What is the function of this protein?
Induces apoptosis and anoikis.  Isoform BimL is more potent than isoform BimEL.  Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS.  Isoform Bim-gamma induces apoptosis.  Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway.  Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
What are the official names of this protein?
Bcl-2-like protein 11, Bcl2-L-11, Bcl2-interacting mediator of cell death.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. SUBCELLULAR LOCATION: [Isoform BimEL]: Mitochondrion. Note=Translocates from microtubules to mitochondria on loss of cell adherence. SUBCELLULAR LOCATION: [Isoform BimL]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform BimS]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform Bim-alpha1]: Mitochondrion.
Protein: HIF3A_MOUSE
Sequence: MDWDQDRSNTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVEKGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPRPNLSKKKLEAPTERHFSLRMKSTLTSRGRTLNLKAATWKVLHCSGHMRAYKPPAQTSPAGSPRSEPPLQCLVLICEAIPHPASLEPPLGRGAFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYEYIHALDSDAVSRSIHTLLSKGQAVTGQYRFLARTGGYLWTQTQATVVSGGRGPQSESIICVHFLISRVEETGVVLSLEQTEQHTRRPPRLSASSQKGIPGNSVDSPAPRILAFLHPPALSEASLAADPRRFCSPDLRRLMAPILDGPPPAATPSTPQATRRPQSPLPADLPDKLTVGLENAHRLSTAQKNKTVETDLDIAQDPDTLDLEMLAPYISMDDDFQLNSSEQLPKVHRRPPRVARRPRARSFHGLSPPIPEPSLLPRWGSDPRLNCSSPSRGDRPTASLMPGTRKRALAQSSEDKGLELLETKPPKRSPRLEPGSFLLPPLSLSFLLQGRQLPGNQQDPRAPLVHSHEPLGLAPSLLSLCQHEETVQPRNRFPPAAGLGQTH
What is the function of this protein?
Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:18070924).  Also plays a role in the development of the lung and heart during embryonic and neonatal stages (PubMed:18070924).
What are the official names of this protein?
Hypoxia-inducible factor 3-alpha, HIF-3-alpha, HIF3-alpha, Basic-helix-loop-helix-PAS protein MOP7, HIF3-alpha-1, Inhibitory PAS domain protein, IPAS, Member of PAS protein 7, Neonatal and embryonic PAS protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions. Colocalized with HIF1A in kidney tumors. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Nucleus speckle. Mitochondrion. Note=Colocalizes with BAD in the cytoplasm (PubMed:21546903). Colocalizes with EPAS1 and HIF1A in the nucleus and speckles (PubMed:21546903). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:24092767).
Protein: DAPA_THET2
Sequence: MFRGSIPPLPTPFRRGRLDEEALRRLVERVVQGGSHGVSVGGTTGEPGTQTLEERKRAIEVVLDQVAGRVPVIPGTGALRLEETLELTRFAKEAGAQGAMVIVPYYVKPNQEGLYRYFAEVARAVPDFPLLIYNIPGRAGVEIAPKTVGRLRRDFPNIVGLKHSSKDLEYLSHLFLEAGRDFLVFCGLESLTLPMMSLGAVGTIAATANWLPKEVALLCEKALAGDYQGARELHFYLLEANEAIFWDTNPIPLKTVLSWMGLLEKEWRPPLGPTTPEVEERLRRMAERYGLLPKEKEAA
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNRF4_MOUSE
Sequence: MARFAWTRVAPVALVTFWLVLSLSPTDAQVNLSSVDFLDLPALLGVPVDPKRARGYLLVARPADACHAIEGPWPDNHSLDPLVLVRPLGCSWEQTGRRAQRAGATAASVGPEAPGQLREFEDLEVTVRCDQPARVLLPHAEPCPDPECHPVVVASWALARALALAASTLFVLRQLWPWVRGLGSRGTAVKTQTCQKAQVRTFTRLSDLCAICLDDYEEGERLKILPCAHAYHCRCIDPWFSRAAQRSCPLCKQSVASTHDGSTDGSVGGEEPPLPGHRPPIWAIQARLRSRRLELLARTVPCRRCSSTTSLGVAENVAQSEATSELS
What is the function of this protein?
E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (By similarity).  Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (By similarity).  Could have a role in spermatogenesis (PubMed:10191088).
What are the official names of this protein?
E3 ubiquitin-protein ligase ZNRF4, RING-type E3 ubiquitin transferase ZNRF4, Sperizin, Zinc/RING finger protein 4.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: MOB4_DROME
Sequence: MKMADGSTILRRNRPGTKSKDFCRWPDEPLEEMDSTLAVQQYIQQLIKRDPSNVELILTMPEAQDEGVWKYEHLRQFCMELNGLAVRLQKECSPSTCTQMTATDQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVTKLGSVCRRVYRIFSHAYFHHRRIFDEFEAETYLCHRFTHFVTKYNLMSKENLIVPINVGENAAPGESEA
What are the official names of this protein?
MOB kinase activator-like 4, Mob as tumor suppressor protein 4, Dmob4, Mps one binder kinase activator-like 4.
What is the protein family that this protein belongs to?
Belongs to the MOB1/phocein family.
Protein: END8_KLEP7
Sequence: MPEGPEIRRAADKLEAAIKGEPLTNVWFAFPQLQPYQTQLTGQRVTHIATRGKALLTHFSGGLTLYSHNQLYGVWRVVDAGVEPQSNRVLRVRLQTASKAILLYSASDIDILTAEQVANHPFLLRVGPDVLDMTLTAEQVKARLLSAKFRNRQFSGLLLDQAFLAGLGNYLRVEILWQVGLSGKRKAAELSDSQLDALAHALLDIPRLSYRTRGLVDDNKHHGALFRFKVFHRDGERCERCGGIIEKTTLSSRPFYWCPGCQH
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: NSP5_ROTHK
Sequence: MSLSIDVTSLPSISSSIFKNESSSTTSTLSGKSIGRNEQYVSPDIDAFNKYMLSKSPEDIGPSDSASNDPLTSFSIRSNAVKTNADAGVSMDSSTQSRPSSNVGCDQMDFSLNKGINVSASLDSCVSISTNQKKEKSKKDKSRKHYPRIEADSDSEDYVLDDSDSDDGKCKNCKYKKKYFALRMRMKQVAMQLIEDL
What is the function of this protein?
Plays an essential role in the viral genome replication.  Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories.
What are the official names of this protein?
Non-structural protein 5, NSP5, NS26.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP5 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RL7_RHOCS
Sequence: MSKLEKLVEDLSALTVLEAAELSKMLEEKWGVSAAAPVAVAAAPAAAAAAAAPVEEQTEFTVILVDGGDKKINVIKEVRAITNLGLKEAKDLVEGAPKTVKEGATKDEAAKIKKQLEEAGAKVDIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: NU2M_PONAB
Sequence: MNPLAQPIIYPTIFTGTLITALSSHWFFAWLGLEMNMLAFIPVLTKKTSPRSTEAAIKYFLTQATASMILLMAILYNNMLSGQWTTTNTTNPYSSLMIVTALAMKLGMAPFHFWVPEVTQGVPLTSGLLLLTWQKLAPISIMYQMSSSVDTNILLTLSILSILVGGWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPDITILNLIIYIILTTTAFLILDLNSSVTILMLTRTWNKLTWLMPLIPSTLLSLGGLPPLTGFLPKWAIIEEFAKNGNLITPTIMAIITLLNLYFYVRLIYATSITLLPMSNNAKMKWQFENTKPTPLLPTLTILTTLLLPISPLILSIS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RK16_ANTAG
Sequence: MLSPKRVKFRKQHRGRMKGISTRGNQICSGKFAPQALEPAWITSRQIEAGRRAISRYARRGGKIWIRIFPDKPVTMRPAETRMGSGKGSPEFWVSVVKPNRILYEIGGVPEDIAKAAIRIAAYKMPIRTQFIILHL
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DPM1_PIG
Sequence: MASEEASRNSRSRWEPEGRFPRQDKYSVLLPTYNERENLPLIVWLLVKSFSESGINYEIIIIDDGSPDGTRDIAEQLVKIYGSDKILLRPREKKLGLGTAYIHGMKHATGNYIIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFITQILLRPGASDLTGSFRLYRKEVLQKLIEKCVSKGYVFQMEMIVRARQLNYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTLFATT
What is the function of this protein?
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.
What are the official names of this protein?
Dolichol-phosphate mannosyltransferase subunit 1, Dolichol-phosphate mannose synthase subunit 1, DPM synthase subunit 1, Dolichyl-phosphate beta-D-mannosyltransferase subunit 1, Mannose-P-dolichol synthase subunit 1, MPD synthase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: CAB32_DROME
Sequence: MDSAAAAAAKRVQIEKAHNFMRQYRDPESRELKKLSANQFMDVWAHYDKDGNGYIEGTELDGFLREFVSSANATDISPEAVTDTMLEELKSCFMEAYDDNQDGKIDIRELAQLLPMEENFLLLFRFDNPLESSVEFMKIWREYDTDNSGYIEADELKNFLRDLLKEAKKINDVSEDKLIEYTDTMLQVFDANKDGRLQLSEMAKLLPVKENFLCRQVFKGATKLTKEDIEKVFSLYDRDNSGTIENEELKGFLKDLLELVKKDDYDAQDLAAFEETIMRGVGTDKHGKISRKELTMILLTLAKISPDDEE
What are the official names of this protein?
Calbindin-32.
What is the protein family that this protein belongs to?
Belongs to the calbindin family.
Protein: Y148_UREP2
Sequence: MLNKNKRWYLIALYDIYQGLLTTKQCEYFNLHYFKDLSFSEIAELKEISKSAISDCLNKVCDQLLKYEQALLIYEKNKKRNDLYTLINDSELVKKLKDI
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein UPA3_0148.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: LOLA_PSEPW
Sequence: MRAIRMLLVSALTLGSLSATLSAHAGEQDVQRLTQLLEKSQTIEANFSQLTLDAGGTSLQETTGKMTVKRPGLFYWHTDAPQEQVVVSDGKNVTLWDPDLEQATIKKLDVRLNQTPALLLSGDVSKISQSFDITSKEQGEVMDFTLKPTTKDTLFDSLRVSFRRGLINDMQLIDSVGQRTNILFNGVKANQAVPDSTFKFDIPKGADVIKE
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.