PharMolix/UniProtQA huggingface dataset:
Protein: PUR9_ROSDO
Sequence: MTDLAPLRRALLSVSDKTGLVALGKALAARGVELLSTGGTARALRDAGLEVKDVAEVTGFPEMMDGRVKTLHPAVHGGLLALRDNDDHLAAMQEHGIAGIDLVVVNLYPFEQTVAKGAQYDEVIENIDIGGPAMIRSAAKNHGFVSVVVDVEDYDVLIAQLEAYDGHTTYALRQRLAQTAYARTAAYDTAVSTWMAAQVGEPPRRRSFGGTLAQTLRYGENPHQDAAFYLDGSNSPGVATARQLQGKELSYNNINDTDAAFELVSEFDQGDGPACAIIKHANPCGVARAETLTEAYRRAFDCDRTSAFGGIIALNQPLDGATAEEISSIFTEVVIAPGADAEAQEVFAKKKNLRLLTTDGLADPTAPGLAIRQVSGGYLVQDRDTGRLSADALQIVTKRAPSDQEMADLMFAWTVAKHVKSNAIIYVKDGATVGVGAGQMSRVDSTRIAARKAQDMAEAMGLPAPLTQGSVVASDAFFPFADGLITAAEAGATALIQPGGSMRDDEVIAAADEAGLAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: CCNB2_CHICK
Sequence: MALTRRAAVMRGVENAVTGHNTKAKVQVTGKRAVLEEIGNKVARGSNVPKKTDCIKPPVKATKGPGKMTNTVVPPKPPAAVNQAVKDTTTASKVLSPVPMDVSMQEEDLCQAFSDVLLHNIEDIDADDSGNPQLCSDYVKDIYLYLRQLELQQSVRPHYLDGKTINGRMRAILVDWLVQVHSRFQLLQETLYMCVAVMDRFLQSHPVPRKRLQLVGVTALLLASKYEEMYSPDIADFVYITDNAYNSAEVREMEITILKELNFDLGRPLPLHFLRRASKAGEADAEQHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLGHDKWGTKQQYYTGYAEDSLAMTMKHMAKNVVKVNENLTKYTAVRNKYASSKLLRISTISQLNSKTIKDLAASLL
What is the function of this protein?
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
What are the official names of this protein?
G2/mitotic-specific cyclin-B2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
Protein: SYM_XANCB
Sequence: MTRTALVTTALPYANGPLHLGHLVGYIQADIWVRARRLRGDKTWFVCADDTHGTPIMLAAEKAGVTPEAFIANIQASHERDFAAFGVTFDHYDSTNSPVNRELTEAFYTKLEAAGHISRRSVAQFYDPAKGMFLPDRYIKGICPNCGSADQYGDNCEVCGATYAPTELKEPKSVISGATPELRDSEHFFFEVGHFDGFLREWLDGDVALPGVKAKLKEWLDAEGGLRAWDISRDAPYFGFQIPGQPGKYFYVWLDAPIGYLCSFKTLCAQMGEDFQAHLAAGTQTELHHFIGKDIVNFHGLFWPAVLHGTGHRAPTRLHVNGYLMVDGAKMSKSRGTFVMARTFLDVGLEPEALRYYFAAKSSGGVDDLDLNLGDFVARVNADLVGKFVNLASRCAGFIGKRFDGKLADALPDPAQYARFVEALAPIREAYERNDPASAIRQTMALADEANKYIDDTKPWVIAKQEGADAQLQSVCTQGLNLFRLLVAALKPILPRTAAEAEAFLSAPMTSWEDVSRPLTCHVIQPYTALFTRIDPKLIDAMTDASKDTMAAPAAPAATTKPAPSKADAAPAAVANPQSPTANPGFIGMDDFAKLDLRIGKVLVCEAVEGSDKLLRFELDAGELGKRQIFSGIRASYGEPETLVGRSVVFIANLAPRKMRFGISEGMILSAGFDGGTLALLDADAGAQPGMPVR
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_ANAMM
Sequence: MQRFKISSEFNPSGDQPGAIDSLVRGISCGAKEQTLLGVTGSGKTFTMASVIEQTQRPAIIIAHNKTLAAQLHEEMRSFFPENAVEYFVSYYDYYQPEAYIPQSDVYIEKDALINDKIDLLRHSATRSLLERRDVVVVASVSCIYGLGSPELYSEMTVPIALGMKLDMCQLQERLVELQYKHGNRYERGNFSVQGDVLSVFPSHYEDRIWKISFFGDEVDSIQEVDPKSGMVTLKLEKIKIFPNSHYVTPRPTLLQAISEIEKELDECALQFKQCNKIVEADRIVERTRFDIEMMRETGTCKGIENYSRYLCGKEAGDPPNTLLDYLPQDAIMFIDESHMTVPQIRAMYNGDRMRKANLINHGFRMPSALDNRPLTFAEWEDRKPTVVYVSATPGQYELQQTGGVATEQLIRPTGLLDPVCIVKGADGQIHDVMCESQATIARGYRVLITTLTKKMAENLTEYMREMGIKVAYLHSDVKTLERIEIISDLRLGVIDVLVGVNLMREGLDIPECALVGILDADKEGFLRSTTSLIQTIGRAARNVEGRVILYANVITKSMRTAMEETDRRRDIQRKYNQEHSIVPRTIQKPVQTSLSERVGSSRKKVSRDTNTDPANRDIVELQKEMLLCAENLDFERAVEIRNEIKRLTAP
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA1_RALSO
Sequence: MTAIDLNADLGEGCDNDEALLALVSSANIACGWHAGDVNTMRQTTAWALRQGVSIGAHPSFPDRENFGRTEMHLPPDEVYAGVLFQIGGLSAIVRAQGGRLAHVKPHGALYNQAARDRPLAMAIARAVRDFDASLAVFGLAGGELVLAARELGLAAKEEVFADRGYNADGTLVKRGTPGALLENEEAALSQTLAMVREQRVQSVDGVWVPIRAQTVCLHGDGAHALAFARRIRDRLGSEGIAVRAGA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A 1, 5-OPase subunit A 1, 5-oxoprolinase (ATP-hydrolyzing) subunit A 1.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: CCSA_SYNJB
Sequence: MALLAITALAGMDLAQWQALLNNVAFAISLGAMLFYWGGAAFPQMQLLAELGLAGMIGANLTMAALLTARWIDAGYFPLSNLYESLFFLAWGITALHLLALHWSRSRWVGVMTAPVVTGIVAFAALVLPEDMQVAQPLVPALQSNWLMMHVTVMLLAYAALLVGSLLSISFLIVTRGQEVHLKGNSLGLQFRPPQPQTHPEWAEATLPSPASELAYAGLRSPRPAPSSAELPPQPAPEGIPWQRLSLAEILDNTSYRLIGLGFPLLTIGIIAGAVWANEAWGTYWSWDPKETWALITWLVFAAYLHARITKGWQGRRPALLASLGFGVVWVCYLGVNFLGKGLHSYGWFF
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PSTB_THEFY
Sequence: MAKRIDVSGLHVYYGDFLAVEDVSMTIEPRSVTAFIGSSGCGKSTFLRTLNRMHEVTPGARVEGKVLLDDQDIYAPDVDPVEVRREVGMVFQRPNPFPTMSIYDNVIAGYKLNNRRLRKSEADEIVERSLRGANLWEEVKDRLDRPGASLSGGQQQRLCIARAIAVEPSVLLMDEPCSALDPISTLAIEDLISQLKENYTIVIVTHNMQQAARVSDVTAFFNLAGTGKPGKLIEIGETNKIFTKPEKKETENYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GRA2A_POGPU
Sequence: FIGGIISLIKKLF
What is the function of this protein?
Has lytic, hemolytic and antibacterial activities.
What are the official names of this protein?
Grammistin Pp 2a.
What is the protein family that this protein belongs to?
Belongs to the grammistin family. Group 2 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LFTR_NEIMA
Sequence: MRIPLLAPDNYAFPDPAYALAWCDGLVGVSGDLDAGRLLEAYQNGVFPWFLRDGWFFWYAVGPRAVIVPERLHVPCSLAKTLRNGSYRVAVNGCFAEVVAHCAAAARPNQDGTWIAPEFQTAYLKLHEMGYAHSFECHYPDENGKTRLAGGFYGVQIGRVFYGESMFALQPDASKIAFACAVPFLADLGVELIDCQQDTEHMRRFGSELLPFADFAERLRMLNAVPLKEEIGRREVACRGL
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFGM_YARLI
Sequence: MIRSLRAVSRLGARGFSSFAAARQENTTVGTTYQEELDVVNQLKGSVTADDVTRLARMRNIGISAHIDSGKTTFSERILFYTGRTKEIHEVRGKDGVGAKMDHMDLEREKGITIQSAATYATWIKENQDYHFNVIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTMTVDRQMRRYNVPRVTFINKMDRMGADPWKAIDQINAKLKTRAAAIQVPIGSEGDLAGVVDIVKEVAYYNDGASGETIRVAEIPEDLKELVAEKRDLLIQTLADVDDEIAECYILEETPTEEQLRGAIRRATIARTFTPVLMGSALANRGVQPVLDAICEYLPDPSDVVNTALDIKKDETPVHLTPAAKAPFVGLAFKLEDGKYGQLTYLRVYQGQLKKGMSIINAKTGKKTKLARLVRMHSDEMEDVDSVGAGEICATFGVDCASGDTFTDGEVTYSMSSMFVPDPVISLAITPKDKGSLTNFSKAMNRFQKEDPTFRVHFDAESKETIISGMGELHLEIYVERMKREYNVVCETGKPQVAYRETITTAAPLDFTHKRQSGGAGQYARIIGEMSPVTDMNAVNEGKATFAAENIFKSEIVGGKIPEKFILACDRSFHETAEKGPLTGSRVLGVEMLINDGNTHVVDSSELAFKVATQRGFYETFMQCSPVILEPIMTVTLTAPVEFQGALIALMNKNQALISDQDIGSEEVTLSGECSLNQMFGFATHLRACTQGKGEFSLEFSHYAPCSPHLQKELVDAHQKKLQAERDGK
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: METK_PROM1
Sequence: MSRYVFTSESVTEGHPDKICDQVSDAVLDACLSEDPTSRVACEAVVNTGLCLITGEITSKAEVDFNKLVREVIKSIGYRSASDGGFDANSCAVLVALDQQSSDIAQGVNEAEDHSTDPLDQVGAGDQGIMFGFACDETPELMPLPISLAHRLARRLALVRHQQLIDYLLPDGKTQVSVSYENGVPCSIDTILISTQHKSEVDGITLEEEIQKRIAKDLWKFVVEPATEDLPLKPAKESTRFLVNPTGKFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARFVAKALVAANLAKKVEVQLSYAIGVAKPISILVDSFGTGKVSDSELTQLVQDQFDLRPGAIIKAFDLQNLPSVRGGRFYRDTAAYGHFGRTDILLPWEDVSQKAKELSLLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_TREDE
Sequence: MDTDKLLSKDLLSNGILLKGLKELGINEKAHNKLSKLLNIYMRELKMFNASFNLVKVKDDEELIVAHILDSLSAWRFFYNETKNTESKTSLNNAETKNTNEALLTSEPFYIADAGTGAGFPGVPLAALFISLGNLDVKLSLIERMQKRCTFLENIKAVLQLNNTEIIESEAEKAPQNKFDIVTCRAFHTLDKHILQTLLNLAKPKGKLFLYKAAKEKINEETELIKKEGLNYKTEKLDVPFLKKERHLLIIEKP
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCS1_DANRE
Sequence: MTLSDFIGALKDNPYFGAGFGLVGVGTALAVARKGAQVGMIFFRRHYMITLEVPSKDKSYHWLLSWITKHAKHTQHLSVETSYMQHESGKVHTQFDFHPSPGNHIIWYGRKWIRVERVREKQMMDLHTGTPWESVTFTALGRDRQTFFNILQEARELALKQEEGRTVMYTAMGAEWRPFGFPRRRRPLSSVVLESGVAERIVDDVKEFIGNPKWYTDRGIPYRRGYLLYGPPGCGKSSFITALAGELGYSICLMSLSDRSLSDDRLNHLLSVAPQQSIILLEDVDAAFVSRELLPTENPLAYQGMGRLTFSGLLNALDGVASSEARIVFMTTNFIERLDPALVRPGRVDLKQYVGHCSHWQLTQMFRRFYPQESAAEADHFSEQALAAHTDLSAAQVQGHFMLYKTDPAGAIKNIAEIKD
What is the function of this protein?
Chaperone necessary for the assembly of mitochondrial respiratory chain complex III.
What are the official names of this protein?
Mitochondrial chaperone BCS1, BCS1-like protein.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. BCS1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: HIS8_BUCSC
Sequence: MNIKQLVRKNIQELQPYQSARTIGGKGDIWLNANECPTFNRLKLENIFLNRYPECQPRELLLRYSSYIGLDKKNILITRGSDEAIELLIKTFCEPQCDRIVFCPPTYDMYNVSANIMGVECLQIPLLNHSWQLDLKVIKKCINNFKLIYLCNPNNPTGSLINFRDVLALLKMTYGKSLVIIDEAYIEFSPMNSLVNLISQYSNLVVLRTLSKAFSLAGLRCGFVLANFSVIKFLLKVINPYPISTPTSSIAIQFLSNINISKMQDRVFSLILNRCWLINELKLISNCIDHIFYSASNYVLVRFRNSNKVFHELSNQGIIVRDQSKKINLKNCIRISIGTSQECLKVIHAIRKIDCLYVN
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: ACTI2_STRCO
Sequence: MSVLITGVGVVAPNGLGLAPYWSAVLDGRHGLGPVTRFDVSRYPATLAGQIDDFHAPDHIPGRLLPQTDPSTRLALTAADWALQDAKADPESLTDYDMGVVTANACGGFDFTHREFRKLWSEGPKSVSVYESFAWFYAVNTGQISIRHGMRGPSSALVAEQAGGLDALGHARRTIRRGTPLVVSGGVDSALDPWGWVSQIASGRISTATDPDRAYLPFDERAAGYVPGEGGAILVLEDSAAAEARGRHDAYGELAGCASTFDPAPGSGRPAGLERAIRLALNDAGTGPEDVDVVFADGAGVPELDAAEARAIGRVFGREGVPVTVPKTTTGRLYSGGGPLDVVTALMSLREGVIAPTAGVTSVPREYGIDLVLGEPRSTAPRTALVLARGRWGFNSAAVLRRFAPTP
What are the official names of this protein?
Actinorhodin polyketide putative beta-ketoacyl synthase 2, actI ORF2.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Protein: HIS82_LEGPA
Sequence: MSIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLALSAIQTMSSHYIATYPSPWNHPLMSKLASYLKVKPEQLFLSNGSDYLFNILLNCFALHTDRHILTHDYAFSTYAIQANSLQIPINSVPIGHNWEVNITDIVNACNQQTGIIFIANPNNPTGMLIQQEEIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYGMAGLRLGYAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMSQLQAGFNELNIKYLHSSCNFLTFDCEEDSIALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTKEQNSRFLTALKNFYL
What are the official names of this protein?
Histidinol-phosphate aminotransferase 2, Imidazole acetol-phosphate transaminase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: NANA_PASMU
Sequence: MKNLKGIFSALLVSFNADGSINEKGLRQIVRYNIDKMKVDGLYVGGSTGENFMLSTEEKKEIFRIAKDEAKDEIALIAQVGSVNLQEAIELGKYATELGYDSLSAVTPFYYKFSFPEIKHYYDSIIEATGNYMIVYSIPFLTGVNIGVEQFGELYKNPKVLGVKFTAGDFYLLERLKKAYPNHLIWAGFDEMMLPAASLGVDGAIGSTFNVNGVRARQIFELTQAGKLKEALEIQHVTNDLIEGILANGLYLTIKELLKLDGVEAGYCREPMTKELSPEKVAFAKELKAKYLS
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHDW_ECO57
Sequence: MKKMMIATLAAASVLLAVANQAHAGATLDAVQKKGFVQCGISDGLPGFSYADADGKFSGIDVDVCRGVAAAVFGDDTKVKYTPLTAKERFTALQSGEVDLLSRNTTWTSSRDAGMGMAFTGVTYYDGIGFLTHDKAGLKSAKELDGATVCIQAGTDTELNVADYFKANNMKYTPVTFDRSDESAKALESGRCDTLASDQSQLYALRIKLSNPAEWIVLPEVISKEPLGPVVRRGDDEWFSIVRWTLFAMLNAEEMGINSQNVDEKAANPATPDMAHLLGKEGDYGKDLKLDNKWAYNIIKQVGNYSEIFERNVGSESPLKIKRGQNNLWNNGGIQYAPPVR
What is the function of this protein?
Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid.
What are the official names of this protein?
Putative amino-acid ABC transporter-binding protein YhdW.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 3 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ENV_HV1AN
Sequence: MIVTMKAMEKRNKKLWTLYLAMALITPCLSLRQLYATVYAGVPVWEDATPVLFCASDANLTSTEKHNIWASQACVPTDPTPYEYPLHNVTDDFNIWKNYMVEQMQEDIISLWDQSLKPCVQMTFLCVQMECTNIAGTTNENLMKKCEFNVTTVIKDKKEKKQALFYVSDLMELNETSSTNKTNSKMYTLTNCNSTTITQACPKVSFEPIPIHYCAPAGYAIFKCNSTEFNGTGTCRNITVVTCTHGIRPTVSTQLILNGTLSKGKIRMMAKDILEGGKNIIVTLNSTLNMTCERPQIDIQEMRIGPMAWYSMGIGGTAGNSSRAAYCKYNATDWGKILKQTAERYLELVNNTGSINMTFNHSSGGDLEVTHLHFNCHGEFFYCNTAKMFNYTFSCNGTTCSVSNVSQGNNGTLPCKLRQVVRSWIRGQSGLYAPPIKGNLTCMSNITGMILQMDNTWNSSNNNVTFRPIGGDMKDIWRTELFNYKVVRVKPFSVAPTRIARPVISTRTHREKRAVGLGMLFLGVLSAAGSTMGAAATTLAVQTHTLLKGIVQQQDNLLRAIQAQQQLLRLSXWGIRQLRARLLALETLLQNQQLLSLWGCKGKLVCYTSVKWNRTWIGNESIWDTLTWQEWDRQISNISSTIYEEIQKAQVQQEQNEKKLLELDEWASIWNWLDITKWLWYIKIAIIIVGALVGVRVIMIVLNIVKNIRQGYQPLSLQIPNHHQEEAGTPGRTGGGGGEEGRPRWIPSPQGFLPLLYTDLRTIILWTYHLLSNLASGIQKVISYLRLGLWILGQKIINVCRICAAVTQYWLQELQNSATSLLDTLAVAVANWTDGIIAGIQRIGTGIRNIPRRIRQGLERSLL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: YACG_CAUVN
Sequence: MSAKCPICAKPVDSAFRPFCSKRCADVDLQRWLSGRYVVAGGDDDEENPPSQDINRE
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: NLPI_ECODH
Sequence: MKPFLRWCFVATALTLAGCSNTSWRKSEVLAVPLQPTLQQEVILARMEQILASRALTDDERAQLLYERGVLYDSLGLRALARNDFSQALAIRPDMPEVFNYLGIYLTQAGNFDAAYEAFDSVLELDPTYNYAHLNRGIALYYGGRDKLAQDDLLAFYQDDPNDPFRSLWLYLAEQKLDEKQAKEVLKQHFEKSDKEQWGWNIVEFYLGNISEQTLMERLKADATDNTSLAEHLSETNFYLGKYYLSLGDLDSATALFKLAVANNVHNFVEHRYALLELSLLGQDQDDLAESDQQ
What is the function of this protein?
May be involved in cell division.  May play a role in bacterial septation or regulation of cell wall degradation during cell division (By similarity).
What are the official names of this protein?
Lipoprotein NlpI.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: BOL8_BOMLA
Sequence: LKLKSILGKLGVILSHLNK
What is the function of this protein?
Mast cell degranulating peptide.  May also display antibacterial and antifungal activities (By similarity).
What are the official names of this protein?
Bombolitin-8.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Bombolitin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GATB_CAMJR
Sequence: MFEVVIGLEVHTQLNTKTKIFCSCATSFGEAPNTNVCPTCLALPGALPVLNEEAVKKAIAFGKAVNATINKKSVFNRKNYFYPDLPKAYQISQFDIPIVEKGELFINVKGENKRIGITRAHLEEDAGKNIHENNFSKVDLNRAGTPLLEIVSEPELRSSDEAVAYLKKLHSIIRFLDISDANMQEGSFRCDANVSIRPKGDTKLYTRVEIKNLNSFRFIQKAIEYEVKRQSEAWEDGTYEQEVVQETRLFDTTNLVTRSMRGKEEAAEYRYFPDPDLLPVLLKDEFLDIKIPELPDEKKARFIDELGIKESDAEVLISSLEMSRFFESLISQNLNPKLCVNWLNTELMGLLKGELTIENSPVDAQKLGILIKRIEDGTISAKAAKDVLAFVFENTSVEIDEAIEKLGLKQVSDDSAIEAVIEQILNANADKVAEYKSGKEKLFGFFVGQTMKEGKGAFNPAKVNEILKTKLG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: EX7S_DESRM
Sequence: MKAEKKTFEEALARLEQVVRELELTQLPLDQALELFAEGITLSKYCNSCLEQAEQKISMLMADGELKDIPGALSGGSSREL
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROL_ECOHS
Sequence: MTQPLFLIGPRGCGKTTVGMALADSLNRRFVDTDQWLQSQLNMTVAEIVEREEWAGFRARETAALEAVTAPSTVIATGGGIILTEFNRHFMQNNGIVVYLCAPVSVLVNRLQAAPEEDLRPTLTGKPLSEEVQEVLEERDALYREVAHIIIDATNEPSQVISEIRSALAQTINC
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFNE_HUMAN
Sequence: MIIKHFFGTVLVLLASTTIFSLDLKLIIFQQRQVNQESLKLLNKLQTLSIQQCLPHRKNFLLPQKSLSPQQYQKGHTLAILHEMLQQIFSLFRANISLDGWEENHTEKFLIQLHQQLEYLEALMGLEAEKLSGTLGSDNLRLQVKMYFRRIHDYLENQDYSTCAWAIVQVEISRCLFFVFSLTEKLSKQGRPLNDMKQELTTEFRSPR
What is the function of this protein?
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract.  Directly mediates protection against viral and bacterial genital infections (By similarity).
What are the official names of this protein?
Interferon epsilon, IFN-epsilon, Interferon epsilon-1.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family.
What are the subcellular locations of this protein?
Secreted.