PharMolix/UniProtQA huggingface dataset:
Protein: ANDH_EMEVA
Sequence: MPSLSQIRQANELLEDSHSEIVAAFVGGTSGVGEEAAKRLASCVRKPEIFIVGRNEESAARVLAELRNANPQGSYQFVKVDISLLRNVDRACEAIRHKTQTLDLLFISAGSALVAREDTEEGLEKNLVERYYARMRFTQSLLPLLQASNKSPRVVSVLLGGFEIELETDNLDLTKPRTAIYSTRHAATMTSLSMEHLATVYRSISFVHIYPGMVKTPLLDKGLGRFLARIAWILYWPFSITLEQSGQYNVYMATSAAYPPLSPENQQGAGASLAEGGEICIGSTGKVGAGSYILNYDGANRTNVKLMEGYRVRDYAQHIWTHTLSTFQTVTGSAEPA
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of anditomin, a fungal meroterpenoid (PubMed:25216349).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase andM (PubMed:25216349).  DMOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHDMP) by the cytochrome P450 monooxygenase andK, which is further prenylated by the prenyltransferase andD to yield farnesyl-DHDMP (PubMed:25216349).  Further epoxidation by the FAD-dependent monooxygenase andE leads to epoxyfarnesyl-DHDMP (PubMed:25216349).  The next step involves the terpene cyclase andB that converts epoxyfarnesyl-DHDMP into preandiloid A through opening of the epoxide ring followed by the cyclization of the farnesyl moiety (PubMed:25216349).  Preandiloid A is in turn oxidized at the C-3 hydroxyl group to yield preandiloid B by the dehydrogenase andC (PubMed:25216349).  The dioxygenase andA is solely responsible for the dehydrogenation of preandiloid B leading to the enone preandiloid C, as well as for the intriguing structural rearrangement to generate the bicyclo[2. 2. 2]octane core, transforming preandiloid C into andiconin (PubMed:25216349).  FAD-binding monooxygenase andJ then produces andilesin D which is reduced by dehydrogenase andI to yield andilesin A (PubMed:25216349).  Action of acetyltransferase andG followed by a spontaneous acetate elimination leads then to andilesin B, which is in turn substrate of the short chain dehydrogenase andH to yield andilesin C (PubMed:25216349).  Finally, the dioxygenase andF catalyzes the transformation of andilesin C to anditomin (PubMed:25216349).
What are the official names of this protein?
Oxidoreductase andH, Anditomin synthesis protein H.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family.
Protein: KR134_HUMAN
Sequence: MSYNCCSRNFSSRSFGGYLYYPGSYPSSLVYSTALCSPSTCQLRSSLYRDCQKTCWEPASCQKSCYRPRTSILCCPCQTTCSGSLGFRSSSCRSQGYGSRCCYSLGNGSSGFRFLKYGGCGFPSLSYGSRFCYPNYLASGAWQSSCYRPICGSRFYQFTC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 13-4.
What is the protein family that this protein belongs to?
Belongs to the PMG family.
Protein: GPT11_DANRE
Sequence: MADDEDDYMSDAFLNQISDVRPGVPMVKRVKEAIKKEALHKEKDIQNRQKSFKEQEKESREAALQSSIGSQNKGFALLQKMGYKAGQGLGKEGAGRVEPVPLNIKTDRGGIGMEEVKKRKADEELQNYRRKVHMKQHLEKKSIEDFRVRKRTEREERQTQGDLRKSQRACEQLDNQKGITVPRDCWYWPEVEKNEESELLEEEIKTEESDEEEELTPLDKLQFLTSYLRGVHYYCIWCGTAYNDEEDLGTNCPGDTAADHDD
What are the official names of this protein?
G patch domain-containing protein 11, Coiled-coil domain-containing protein 75.
What is the protein family that this protein belongs to?
Belongs to the GPATCH11 family.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore.
Protein: LCE1F_HUMAN
Sequence: MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCCSSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCSQPSAGSSCCGGGSGQHSGGCC
What is the function of this protein?
Precursors of the cornified envelope of the stratum corneum.
What are the official names of this protein?
Late cornified envelope protein 1F, Late envelope protein 6.
What is the protein family that this protein belongs to?
Belongs to the LCE family.
Protein: PYRG_CHLSY
Sequence: MTKYIFVTGGVVSSVGKGIGVASIGRLLKSRGLSVSVMKLDPYLNVDPGTMSPYQHGEVFVTADGAETDLDLGHYERFIDVNLSRLSNVTTGQIYSAVIAKERRGDYLGGTIQVIPHITNEIKSRIGSLARSSQADVVIVEIGGTVGDIESLPFLEAIRQMRKDVGRDNILYIHVTLLPHISTGELKTKPTQHSVMALRNVGISADIILCRADRPIDDEIREKIAFFADVDVRAVIPVPTVDSIYEVPLVLEDMGLGDYLVERLGLPATPPDLEEWRALVARIRQEKRRVPIALVGKYVELHDAYISVVEALHHAGLEQSIDIDIRWIAAEEVEREGPARLLSGVYGILVPGGFGERGIEGKIAAADYARIHGIPYLGLCLGMQCATIAFARHVLGTHDVNSTEFNPQTAHPVIDLMPDQRDITEKGGTMRLGLYPCDLVPGTRAHAAYGCDRVEERHRHRFEFNNRYRSVLEAAGLVISGISPDKRLVEIIELRDHPWYVASQFHPEFQSRPGKPHPLFRGFVAAAAQTLLAGEARQLPLVESTS
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: Y998_RHIME
Sequence: MALQIIAYVVALIMVVGACFSLLAAVGLVRFPDLYTRMHAASKAGTVGSGLLLFAAGLHSLDAAVFVRALAGFVFFVLTAPISAHLLAKAAHQAGYRMSKRSVIDQLPHKEEARRH
What are the official names of this protein?
UPF0091 protein R00998.
What is the protein family that this protein belongs to?
Belongs to the UPF0091 family.
Protein: TPIS_METAC
Sequence: MGSPFILLNYKTYNQGTGQGAVEIARACRAVSEESGIEIAVAPQLPDIYRVASEVELPIFSQHMDGVGAGSFTGHVFGKCIKEAGAVGTLINHSERRLTLAEIEASLKAAKEFGLRAVICTNNVPTTAAAAALEPDYVAIEPPELIGSGIPVSKADPEVVSGSVEAVAKINSGVKVLCGAGISKGEDLRAALDLGSQGVLLASGIVKAADPKAALEDLIRLV
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_MAGMM
Sequence: MSSTHPGRTIRSGATQNLSGTIRPAADKSISHRSVIFGALAEGETHVKGMLEGEDVLRTITAFRTMGISIERCNEGEYRIQGQGLDGLKEPDDVLDMGNSGTAMRLLCGLLASQPFHSILTGDHSLRSRPMGRVVQPLTKMGARIRGRDGGRLAPLAIEGTELVPITYNSPIASAQVKSAIILAGLNTAGETTIIEPAVSRDHTERMLIAFGAEVTRDGNQVTIEGWPNLQGQEIEVPADISAAAFPMVAALITPGSDIILENVGMNPTRTGILDLLLAMGGNIQRLNEREVGGEPVADLQVRYSQLQGIEIDPTVVPRAIDEFPVFFVAAALAQGQTLVQGAEELRVKESDRITAMANGLKALGAIIEERPDGALITGNPDGLAGGASVDSFTDHRIAMSLLVAGLRCKESVLVQRCDNINTSFPSFSQLMNSLGFQLEDVSHG
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_BEUC1
Sequence: MAKIKKGDLVVVISGNRDDRGKQGRVLEVLTDSNRVVVEGVRRVKKHTKVSQTQRGSRTGGIETIEAPIHVSNVMLVDPETKKGTRVGYRTEEVERNGRARTVRVRVAKRSGKDV
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: CCA_YERPS
Sequence: MNIYLVGGAVRDSLLNLPVTEQDWVVVGATPEQLLKLGYQQVGKDFPVFLHPVSHEEYALARTERKSGQGYTGFTCYAAPDVTLEDDLLRRDLTVNAIARSADGEFIDPYHGKQDLENRVLRHVSDAFGEDPLRVLRVARFAARFAYLGFTIAPETMSLMSNMAQSGELSALTPERVWKETEKALKTQSPHVYFQVLRDCGALAVLFPEIERLFGVPAPEKWHPEIDTGIHTLMTLAIAAQLSPEVDIRFAALCHDLGKGLTPKEHWPHHHGHGPAGVKLVEQLCQRLRIPNPVRDLAKLVAEYHDLIHTVNKLRPETLLKLFNAIDVWRKPERLEQMIMTSEADARGRTGFENNPYPQGDYLRAAFQIANGVSIQEVVASGLQGLAIRDELQRRRQQALAEWKQTQETPLI
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: AL15_ARTBC
Sequence: MKAFAGSFQPWIPQCRSPCICEVAASKDNGVLERPCSTLSVIVNIAVKKSYINPSPPAKMKFTIPATLGLMVSLSSAAAISGTVSLSYDPKYDNAGLSLTQVTCSDGTNGLITKGFTTAGSLPNFPNIGGSFAVEGYNSANCGKCFKVTWPVLNKSIFVTSIDKADGFNVAKAAMDTLTNNQAGQLGRIDVTFEDALPTDCGFKA
What are the official names of this protein?
Allergen Asp f 15 homolog.
What is the protein family that this protein belongs to?
Belongs to the cerato-platanin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TGT_MARN8
Sequence: MSFEKLGEDGKARRGRLTFPRGVVETPAFMPVGTYGTVKGMLPRDIEEIGAHIILGNTFHLMLRPGTEVVKAHGDLHDFTQWQGPILTDSGGFQVFSLGEMRKITEQGVTFRSPVDGSKVELSPEIAIQVQRDLGSDIVMIFDECTPYPATEKQAKESMELSLRWAERSKRAHEGNPAALFGIVQGGMYESLRDQSLEGLEKIGFDGYAIGGLSVGEPKEDMIRILDHLPPKMPEDKPRYLMGVGRPEDIVEAVRRGVDMFDCVMPTRNARNGYLFTSAGIVKIRNAKNRHDTGPLDERCDCYTCKHFSKSYLHHLDKCGEMLGSQLNTIHNLRFYQNLMSGLRGAIEAGTLSDFVSEFYALRGETVPPLGDS
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: FUS_NPVCF
Sequence: MVRTAVLILLLVRFSEPAEHCNAQMNSGPWRIKNLSIAPPKETLQKDVEIEIVETNMDENVIIGYKGYYQAYAYNGGSLDPNTRIEETMETLNVAKEDLLMWSIRRQCEVGEELIDQWGSDSDNCFRNKDGRGVWVFGKELVKRQNNNHFARHTCNRSWRCGVSTAKMYTRLECDNDNDECKVTILDINGASINVTENTVLHRDGVSMVLKQKSTFSRRPEKVACLLIKDDKSDPRSVTREHCLVDNDIFDLSKNTWLCKFNRCIKRKSENVVKQRPPTWRHDVSAKHDEGASATKGDLMHIQEELMYENDLLRMNLELMHAHINKLNNMLHNLIVSVAKVDERLIGNLMNNSVSSTFLSDDTFLLMPCTHPPPHTSNCYNNSIYKEGRWVANTDSSQCIDFNNYKELAIDDDIEFWIPTIGNTTYHENWKDASGWSFIAQQKSNLISTMENTKFGGHTTSLSDITDMAKGELNAKLWSFMLGHAFSFMLTVGVIIFLFCMVRNRSRAY
What is the function of this protein?
Envelope phosphoglycoprotein which mediates the fusion of viral and host endosomal membranes leading to virus entry into the host cell.
What are the official names of this protein?
Major envelope glycoprotein, gp67.
What is the protein family that this protein belongs to?
Belongs to the baculoviridae gp64 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: GAG_HV1AN
Sequence: MGASASVLTGSKLDAWEQIRLKPGSKKKYRLKHLVWASRELERFACNPELLETAEGNEKLLQQLEPALKTGSDSLQSLWNAIVVLWCVHNRYKIGDTQQAIQKLKEVMGSRKSADAAKEDTSARQAGQNYPIVSNAQGQMVHQAISPRTLNAWVKAVEEKAFNPEIIPMFMALSEGAISYDINTMLNAIGGHQGALQVLKEVINEEAVEWDRTHPPPVGPLPPGQIREPTGSDIAGTTSTQQEQIHWTTRPNQPIPVGDIYRKWIVLGLNKMVKMYSPVSILDIKQGPKEPFRDYVDRFYKTLRAEQATQEVKNWMTETLLVQNANPDCKQILKSLGPGATLEEMMVACQGVGGPTHKARVLAEAMATAQQDLKGGYTAVFMQRGQNPIRKGTIKCFNCGKEGHIARNCRAPRKKGCWKCGQEGHQMKDCRNGKQANFLGKYWPPGGTRPGNYVQRPAHPSAPPMEEEVKGQENQEQKGGPNELYPFASLKSLFGTDQ
What is the function of this protein?
Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
What are the official names of this protein?
Gag polyprotein, Pr55Gag.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Gag polyprotein]: Host cell membrane; Lipid-anchor. Host endosome, host multivesicular body. Note=These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly. SUBCELLULAR LOCATION: [Matrix protein p17]: Virion membrane; Lipid-anchor. Host nucleus. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion.
Protein: PITH1_HUMAN
Sequence: MSHGHSHGGGGCRCAAEREEPPEQRGLAYGLYLRIDLERLQCLNESREGSGRGVFKPWEERTDRSKFVESDADEELLFNIPFTGNVKLKGIIIMGEDDDSHPSEMRLYKNIPQMSFDDTEREPDQTFSLNRDLTGELEYATKISRFSNVYHLSIHISKNFGADTTKVFYIGLRGEWTELRRHEVTICNYEASANPADHRVHQVTPQTHFIS
What is the function of this protein?
Promotes megakaryocyte differentiation by up-regulating RUNX1 expression (PubMed:25134913).  Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene (PubMed:25134913).
What are the official names of this protein?
PITH domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PITHD1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSPH_KLEPN
Sequence: MRQRGFTLLEMMLILLLMGVSAGMVLLAFPASRDDSAAQTLARFEAQLRFVQQRGLQTGQFFGVSVHPDRWQFLVLEARDGADPAPADDGWSGYRWLPLRAGRVATSGSIAGGKLNLAFAQGEAWTPGDNPDVLIFPGGEMTPFRLTLGEAPGIAFNARGESLPEPQEAQ
What is the function of this protein?
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.
What are the official names of this protein?
Type II secretion system protein H, T2SS minor pseudopilin H, General secretion pathway protein H, Pullulanase secretion protein PulH.
What is the protein family that this protein belongs to?
Belongs to the GSP H family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DNLJ_ANAD2
Sequence: MKKADASARARELRDRIRAADHAYYVLDQPLLADAEYDRLMHELQALEAEHPELVTADSPTQRVSGAPSERFERVVHREPMLSLGNVQSDDELHEFDARVRRLLGLPDGEPVGYVVEPKLDGLAVELVYRDGAFTSGSTRGDGVNGEDVTANLRVVGGLGANRGVPHALEGRPPPRVEVRGEVLLFKEHFEAMNRQLVRAGEEPFANPRNAAAGTLRQLDWRVTARRPLSFIAYEALLPGGDPWRTHWEKLEELAAWGFETNAENRRCRGLAEVLAYRDRMAERRFELPYDTDGIVVKVDDLDWRRRLGAASKFPRWAVAFKYPPQEEATRIRRIWASVGRTGVLTPVVDFDPVRLSGAMVARATLHNEDEMRRKDILEGDWVLVRRAGEVIPEVVKPLPERRTGAEQPFRFPAECPVCGARVVREEGEKVYRCTGAACPAQLVGRLCHFAQRRALDIEGLGEKLAAGLVERGQVKDFADLYAVPFEVWQQLFSRPRKEQDAGAARELPEKSAQNMVAALERSRKTTLRRFLFALGIPQVGEATAATLARHFGDLARVMDADEEALKGVRDVGPETAAEIRAWTQEPQNRRVVERLLAAGVTPEAEVVEARGPFAGKTVVLTGGLSTMSRDDAKAEIERRGGKVSGSVSRKTYLVVAGEDAGSKLEKARSLGVRIAGEEEFVRLLKE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RED1_MOUSE
Sequence: MDIEDEENMSSSSTDIKENRNLDNMPPKDSSTPGPGEGIPLSNGGGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLTQPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMTPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDATIEVINATTGKDELGRPSRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAREYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSFTP
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing.  This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions.  Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing).  Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1).  Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities.  Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently.  Can inhibit cell proliferation and migration and can stimulate exocytosis.
What are the official names of this protein?
Double-stranded RNA-specific editase 1, RNA-editing deaminase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Note=Shuttles between nucleoli and the nucleoplasm.
Protein: CRCB2_STAEQ
Sequence: MITILLVMLGGGIGAVLRALITNICQRLFNSKIPIATSIVNITGSLIIGFMMGHALDSHHMFPFFVTGVLGGLTTFSTLSSELVNMLSPQFKPIRFVVYSLLQFILGFIACFYGYRI
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACP5_BRANA
Sequence: MATTFSASVSMQATSLATTTRISFQKPVLVSNHGRTNLSFNLSRTRLSISCAAKQETVEKVSEIVKKQLSLKDDQQVVAETKFVDLGADSLDTVEIVMGLEEEFGIQMAEEKAQKIATVEQAAELIEELMQAKK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, chloroplastic, ACP, Clones 28F10, 10H11/11D11, 34F12 and 04F05/05E01.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYGB_STRP2
Sequence: MTKNLLVELGLEELPAYVVTPSEKQLGEKMAAFLKENRLSFEAIQTFSTPRRLAVRVTGLSDKQSDLTEDFKGPAKKIALDSDGNFTKAAQGFVRGKGLTVEDIEFREIKGEEYVYVTKEEVGQAVEAIVPGVVDVLKSLTFPVSMHWAGNSFEYIRPVHTLTVLLDEQEFDLDFLDIKGGRVSRGHRFLGKETKIQSALSYEEDLRKQFVIADPCEREQMIVDQIKKIEAKHGVRIEIDADLLNEVLNLVEYPTAFMGSFDAKYLEVPEEVLVTSMKEHQRYFVVRDQDGKLLPNFISVRNGNAERLKNVIKGNEKVLVARLEDGEFFWREDQKLVISDLVEKLNNVTFHEKIGSLREHMIRTGQITVLLAEKAGLSVDETVDLARAAAIYKFDLLTGMVGEFDELQGIMGEKYTLLAGETPAVAAAIREHYMPTSAEGELPESKVGAVLAIADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDAFGWHIAMDELIDSLYALKFDSLTYENKAEVMDFIKARVDKMMGSTPKDIKEAVLAGSNFVVADMLEAASALVEVSKEEDFKPSVESLSRAFNLAEKAEGVATVDSALFENDQEKALAEAVETLVLSGPASQQLKQLFALSPVIDAFFENTMVMAEDQAVRQNRLAILSQLTKKAAKFACFNQINTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_PARD8
Sequence: MEKHFKRTLITTALPYANGPVHIGHLAGVYVPADIYARYLRLKGEEVLMIGGSDEHGVPITLRAKKEGITPQDVVDRYHGIIKKSFEEFGITFDIYSRTTSATHHQMASDFFRTLYDKGEFIEKTSEQYYDEEAKQFLADRYIMGTCPHCGNEKAYGDQCEACGTSLSPTDLIDPKSAISGSKPVMRETKHWYLPLDKWEPFLRKWILEDHKEWKPNVYGQCKSWLDMGLQPRAVSRDLDWGIPVPVEGAEGKVLYVWFDAPIGYISNTKELLPDSWETWWKDPETKMVHFIGKDNIVFHCIVFPSMLKAEGSYNLPENVPANEFLNLEGDKISTSRNWAVWLNEYLVDMPGKQDVLRYVLTANAPETKDNDFTWKDFQARNNNELVAILGNFVNRALVLTDKYFEGKVPVAGELTDYDRQTLKDFADVKENVERLLDTYHFRDAQKEAMNLARIGNKYLADMEPWKLAKTDMPRVATIMNIALQITANLAIAFEPFLPFSMEKLNKMLNVEPLGWNRLGATDLLEAGHQLGKAELLFEKIEDSVIEAQVQKLLDTKKANEEANYKAKPIRENIEFDDFMKLDIRVGTVLECVKVPKADKLLQFRIDDGLEKRTIVSGIAQHYKPEELVGKQVCFIANLAPRKLKGIVSEGMILSAENFDGKLAVITPEKEVKPGSEVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INVE_SALTI
Sequence: MIPGSTSGISFSRILSRQASHQDATQHTDAQQAEIQQAAEDSSPGAEVQKFVQSTDEMSAALAQFRNRRDYEKKSSNLSNSFERVLEDEALPKAKQILKLISVHGGALEDFLRQARSLFPDPSDLVLVLRELLRRKDLEEIVRKKLESLLKHVEEQTDPKTLKAGINCALKARLFGKTLSLKPGLLRASYRQFIQSESHEVEIYSDWIASYGYQRRLVVLDFIEGSLLTDIDANDASCSRLEFGQLLRRLTQLKMLRSADLLFVSTLLSYSFTKAFNAEESSWLLLMLSLLQQPHEVDSLLADIIGLNALLLSHKEHASFLQIFYQVCKAIPSSLFYEEYWQEELLMALRSMTDIAYKHEMAEQRRTIEKLS
What is the function of this protein?
Involved in the triggering of intracellular events that lead to microbial internalization.  These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli.  Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells.  Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity).
What are the official names of this protein?
Invasion protein InvE.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Note=Probably associated with a bacterial membrane-localized protein.
Protein: LPXH_NEIMB
Sequence: MKPAYFISDLHLSEKQPELTALLLRFLRSSAAGQARAIYILGDLFDFWVGDDEVSELNTSVAREIRKLSDKGVAVFFVRGNRDFLIGQDFCRQAGMTLLPDYSVLDLFGCKTLICHGDTLCTDDRAYQRFRKIVHRKRLQKLFLMLPLKWRTRLATKIRRVSKMEKQVKPADIMDVNAAFTARQVRAFGAERLIHGHTHREHIHHENGFTRIVLGDWHNDYASILRVDGDGAVFVPLEKY
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.