PharMolix/UniProtQA huggingface dataset:
Protein: NCB2B_DROVI
Sequence: MTASIDLSSYRDQHFKGSRSEQERSLRDSTTLYVGNLSFYTTEEQIHELFSRCGDVRIIVMGLDKYKKTPCGFCFVEYYTRAEAEAAMRFVNGTRLDDRLIRVDWDAGFVEGRQYGRGKTGGQVRDEYRTDYDAGRGGYGKLLSQKIAPNTDNR
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi).  The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing.  Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 2B, 20 kDa nuclear cap-binding protein B, NCBP 20 kDa subunit B, CBP20-B.
What is the protein family that this protein belongs to?
Belongs to the RRM NCBP2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLNE_MYCLE
Sequence: MCCTTVVVVRKPATERLKRPSVGRLGLFDPHAAENLALLGWYDYDCREHVDLLWSLSRAPDADAVLRPMVRLFENPATGWDELNAALLTDRGLRGRLFAVLGSSLALGDHLVAHPQSWKLLRGRVSLPSRTQLHQAFDECVSNFGDDPLDAPDSVLPRLRTLYCDQLLVLAALDLAATVEDEPVLPFTLVAAQLADIADAAMATALRVAEKIVCGDRTPPRLAVIAMGKWGARELNYVSDVDIIFVAEQADPLSTRVASEMMRVASEAFFQVDAGLRPEGRNGELVRTVESHIAYYQRWAKTWEFQALLKARSAVGDAELGERYLAALMPMVWAACERADFVAEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHGRSDESLHVVSTVDALAALGEGGYIGREDAANLTASYEFLRLLEHRLQLQRLKRTHLLPEDGDEEAVRWLARAAHIRPDGRHDAAGVLREELKNQNLRVSQLHAKLFYQPLLESIGPASLEIRHGMTSEAAERQLATLGYEGSQTALKHISALVNQSGRRGRVQSVLLPRLLNWMSYAPDPDGGLLAYRRLSEALSAETWYLSTLRDKPAVARRLMHVLGTSVYVPDLLMRAPEVIQSYGDGLAGPKLLEAEPAMVARALITSAGRHTDPIRAIDAARSLRRRELARVGSADLLGLLEVTEVCKALTSVWVAVLQAALDAVIRAYLPDGDKAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPAIGVEDAQALRWSGMIAERVCRLLRTPSVDPPLDVDANLRPEGRNGPLVRTLGAYAAYYAQWAQPWEIQALLRAHAVAGDADLGQRFLLMADKMRYPPDGVSAEAVREIRRMKARVEAERLPRGADPHTHTKLGRGGLADIEWTVQLMQLRHAHELPALHKTSTLESLDAIAAANLIPEADVDLLRQAWLTATRARNALVLVRGKTTDQLPGPGRQLNAVAVAAGWPSDDGSEFLDNYLRVTRRAKTFVRKVFGS
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: YICN_ECOL6
Sequence: MIWIMLATLAVVFVVGFRVLTSGARKAIRRLSDRLNIDVVPVESMVDQMGKSAGDEFLRYLHRPDESHLQNAAQVLLIWQIVIVDGSEQNLLQWHRILQKARLAAPITDAQVRLALGFLRETEPEMQDINAFQMRYNAFFQPAEGVHWLH
What are the official names of this protein?
Uncharacterized protein YicN.
Protein: PA2B1_BUNFA
Sequence: MNPAHLLVLLAVCVSLLGAANIPPQPLNLLQFKNMIQCAGSRLWVAYVKYGCYCGPGGTGTPLDQLDRCCQTHDHCYDNAKKFGNCIPYFKTYEYTCNKPDLTCTDAKGSCARNVCDCDRAAAICFAAAPYNLANFGINKETHCQ
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
What are the official names of this protein?
Basic phospholipase A2 1, svPLA2, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 isozyme I.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SELA_AQUAE
Sequence: MKSLLRQIPQISKVVEIFKKKYPEIYVVKAAREVAEKYRKEIIEGKRKDLNGFLEDVERKIKSLMKPNIKRVINATGVVINTNLGRAPLSKDVINFISEIANGYSNLEYNLEEGKRGSRIAHIEKYLNELTGAESSFVVNNNAGAVFLVLNTLAEGKEVIISRGELVEIGGSFRIPDIMKKSGAILREVGTTNKTKVSDYEGAINQNTALLMKVHKSNFYMEGFVEEVKLEDLVKLGHKYGIPTYYDAGSGLLINLKEFGISVDEPNFRDCISLGIDLVSGSGDKLLGGPQAGIIVGKKNLIEKIKKNPIARALRIDKLTLSGLEMTLKLYFEKRYEDIPVIRMLTQDEKALRQKAKRLEKLLKDIPGLKISVIKDKAKPGGGSLPELELPTYCVAIRHDRLSSQELSRRLRLAEPPIVCRIREDQLLFDMRTVFHEDLKTIKKTLQELLSI
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYSG_MYCTO
Sequence: MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLEQQVGQVLVVREKPCRATTAGIPLLRLAAQTALLESEALAEMGGNASLKRTRITIAVNADSMATWFSAVFDGLGDVLLDVRIEDQDHSARLLREGVAMGAVTTERNPVPGCRVHPLGEMRYLPVASRPFVQRHLSDGFTAAAAAKAPSLAWNRDDGLQDMLVRKAFRRAITRPTHFVPTTEGFTAAARAGLGWGMFPEKLAASPLADGSFVRVCDIHLDVPLYWQCWKLDSPIIARITDTVRAAASGLYRGQQRRRRPG
What is the function of this protein?
Positively regulates the expression of the exporter LysE and represses its own expression.
What are the official names of this protein?
HTH-type transcriptional regulator LysG.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: ZN326_CHICK
Sequence: MDYGEAEDRDWRFPDTPMHCGVNMPSGSVSDMDRDYGHGGYGGPRSMDSYLNQSYGMESHGGGGGGGGGGGNRFGPYESYDSGSSLGGRDLYRSGYGYNEPEQSRFGGSYGGRFDNSYRNSLDSFGGRNQGGSSWEAPYSRSKLRPGFMEDRGRESYSSYSSFSSPHMKPAPVGSRGRGTPAYPESGFGSRNYDAFGGPSTGRGRGRGHMGDFGGMHRPGIVVDYHNKPSPAAVAARGIKRKMMPQPYNKPGGTFIKKPKMTKPILKLTQKKSSNMKSSFQDSTIEEIEVDTSGAVVIYEDFTRDAYDVGYQTFGDSKGEGKSEEEEKRRIEARREKQRRRREKNSEKYGDGYRMAFTCSFCKFRTFEEKEIESHLESAAHQETLDHIQKQTKFDKVVMEFLHECMVNKFKKTAMRKQQTSNQTENAQAVEKDIMEGVTADDHMMKVETVHCSACSVYVPALHSSVQQHLKSPDHTKGKQAYREQIKRESVLTATSILNNPIVKARYELYVKGENPFEINDQAQEQQTEEEDKAEEPAEGEEEEEEEEEEETEEQTDFTLDHTEDN
What is the function of this protein?
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing.
What are the official names of this protein?
DBIRD complex subunit ZNF326, Zinc finger protein 326, Zinc finger protein interacting with mRNPs.
What is the protein family that this protein belongs to?
Belongs to the AKAP95 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEXA_STAAW
Sequence: MRELTKRQSEIYNYIKQVVQTKGYPPSVREIGEAVGLASSSTVHGHLSRLEEKGYIRRDPTKPRAIEIVSDQTNDNINMEETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSDIFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMTEEDEATVKRFYKEKNRYRLQPENSTMEPIYLDNVAVIGKVIGLYREM
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: MURG_XYLFM
Sequence: MSIVVQSAVTHFRPVMILAGGTGGHIFPGLAVAGALRARGVPVVWLGATGKMETHLVPKHGIEIQTIAVAGVRGRGMLALLGAPVRVLRAIFAAMGVLRRYRPRVVVSFGGFAAGPGGIAARFMRLPLIVHEQNRAPGMTNRVLARVAKRVLSGFPGSFVAEEVVGNPVRKDIAGLPAPGVRFSGRSGPVRLLVLGGSQGARVMNDALPVVLRVLSDSDVAVEVRHQCGEALCAETERAYAYAGVAARIEPFISDMAAAYAWADLVVCRAGASTLAELCAAGVGSVLIPFPAAVDDHQTRNAEYLVAAGAALLLQQDRALYVYLESVLRDLLSDPMRRLAMAEAARGLAKSDAAECIAEIVLEESI
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GAMA_BACSU
Sequence: MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLYKQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIPQGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSESTIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTTDVPASILQKHNHVTVIADYKAAQKLKSASFS
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Probable glucosamine-6-phosphate deaminase 2, GlcN6P deaminase 2, GNPDA 2, Glucosamine-6-phosphate isomerase 2.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: UVRC_SHEON
Sequence: MSTGFNAQSFLRTVTSSAGVYRMYDVKGDVIYVGKAKDLKKRLSSYFRKNLGNVKTQALVSHIHHIDVTLTHSETDALLLENDYIKQYMPKYNVLLRDDKSYPYILLSQHEHPRLAYHRGPQREKGHYFGPYPNGGAVRESLHLMQKLFPIRQCDDLYYKSRTRPCLQYQLSRCSAPCVGKVSNAEYDEQVKLASLFLKGKDKQVISELVAKMEEAAEQQAYEQAARFRDQIMALRRVAEQQEVSGNTGDMDVIGVHYASGIACFHLLFIREGKIFGSRSYYPTVPAQTDIEEVLRSFLLQFYLNADIQRTIPKEVVISHHFEELHELEAAVSEALNKKFSIKTNVRADRASFLRLAITNATNAVMTRLSHKNTVEQRFVLLEEILELNAPIQRMECFDISHTMGESTVASCVVFNREGPHKAEYRRYNIEGITPGDDYAAMKQAISRRFDKIDASGKIPDILFIDGGLGQLRIAQQIVDEKFVNLDKAPQLIGVAKGESRKPGLETLIFGDTETSFSLEDDSPALHLIQHIRDESHRFAITGHRNRRQKTRNTSTLESIPGIGPKRRKALLQHLGGLQEVKGASVAELAKVPGISIEMAQTIHDALRG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRAK1_HUMAN
Sequence: MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
What is the function of this protein?
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.  Involved in Toll-like receptor (TLR) and IL-1R signaling pathways.  Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation.  Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation.  Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1.  Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex.  In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation.  Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation.  Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state.  When sumoylated, translocates to the nucleus and phosphorylates STAT3.
What are the official names of this protein?
Interleukin-1 receptor-associated kinase 1, IRAK-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Lipid droplet. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity).
Protein: HPT_HUMAN
Sequence: MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
What is the function of this protein?
The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
What are the official names of this protein?
Haptoglobin, Zonulin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRH_BUCAP
Sequence: MSTNTKFIYHRILLKISGEVLQGVNKFGIDINSLKRIVKEIKLVLQFGIQVGLVIGSGNLFRGATLSQLGVNRIVSDHIGILSTIINSLAMKDIMNSYSIPSYVMSSIPVDGICETYNYERAIDLLSNNFVVIFAAGTGNPLFTTDSAACLRGIEIKSDIILKGTKVDGVYSKDPKKYSQAVFYKRLTYKDVIQKELKVMDLSAFSLARDHNLPIRVFNINKPKSLYRIVKGYDEGTLIK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KYNB_BURO1
Sequence: MDTLWDISPPVSPATPVWPGDTPVAVERVWRMEAGSPVNVARLTLSPHTGAHCDAPLHYDADGAPIGAVPLDTYLGPCRVIHCIGASPVVRPADVEAALDGVPPRVLLRTYARAAVEQWDSNFCAVAPDTVDLLAAHGVKLIGIDTPSLDPQESKTMDAHHRVRAHRMAILEGIVLDDVPPGDYELIALPLKFATLDASPVRAVLRALPAHAS
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.
Protein: Y4IK_SINFN
Sequence: MNAGRQLFVRSIRDFSTFVHTPDAERIKLVESGLMLDDQLREAYRIRGSFTDSRYHTWVCFEFIDKTGVSRYVRFRLINADRGPDRGLPRPEFKANGHPSMDAEADDDRAPDFLRKDFIHRVRHSDVRYILQAQLRDTPPPPVGNHELFDPSQPWNEYWFPWVDMFEIRLNEVIDDQAAVSRLEMNPNRSPECIRIPLATSPDDYASLGHARAIVYPGARAARAAVPPPQNN
What are the official names of this protein?
Uncharacterized protein y4iK.
Protein: SETD3_CANLF
Sequence: MGKKSRVKTQKSGTGATASVSPKETLNLTSELLQKCSSPAPGPGKEWEEYVQIRSLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNITLAFHLLCERADPNSFWQPYIQTLPSEYDTPLYFEEDEVRDLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDAFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALRDFRAGEQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHYTDPPVSAQLLAFLRVFCMTEEELKEHLLGDNALDRIFTLGNSEYPVSWDNEVRLWTFLEDRASLLLKTYKTTIEEDKSFLRNHDLSVRATMAIKLRLGEKEILEKAVKSAAANREHYRKQMQAGAPLPRCEESGTAGARLPLALRDLEAEASVQEALSLTEAVGRAKAVENGLVNGENSIPNGTRSGKENFNQEGSERATEGTKESSSDSTAGARE
What is the function of this protein?
Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'.  Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery.  Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin.
What are the official names of this protein?
Actin-histidine N-methyltransferase, Protein-L-histidine N-tele-methyltransferase, SET domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes mainly in the cytoplasm.
Protein: PROA_LACE2
Sequence: MESLEQIGIKAKKASRYLAKLGIDEKNKALEAVADALTANAESIIAANEKDLVNAKANGMKPALIDRLTLDIKRINAMADGIRVLTGLEDPVGEVTGMKKRPNGLVIGTKRVPLGVVAIIYESRPNVTADAFGLTFKSGNACILRGGSDSINSNIAIADVIANALSDNGINPDVINLIKDTDRALVNQLMKMNDYIDVIIPRGGAGLIKNVVNNSTVPVIETGTGNCHVYVDEYADIDMAVKVIYNAKTSRIGVCNACESLVIHKAVAKQAIPLIVNALKEKNVEVRGDEYAMQCDSRIVPASDDDWGMEYLDYIISVKTVDSVDEAIEHINTYNTGHSESIITKDYNNANRFLDEIDAACVYVNASTRFSDGFEFGFGAEIGISTQKLHARGPMGLKALTTTKYVIYGEGQIRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1051_ARCFU
Sequence: MVMAMGFDTVVAAIMATAIIVAVAYTFLAGSTSIAELSVESYKDAVNSAVKKLRSDIEILSVSYDNSTSKIVAYFKNTGDERYPDFSEFDAIVYGRTSGGEMVSFYVNSTVFSITNELINPGIFDPQEVAKLEAVQPLQNGTYVLLICTPNAVCDSADFSV
What are the official names of this protein?
Uncharacterized protein AF_1051.
Protein: AMP2_CAEEL
Sequence: MRRKLLLLLCFIGLFSLISTAPAPNNVGLESEFTEGHAETINLEEVEFNHPSILPEHPDNFRQDKLAARKRQSLYVTKTRLPPNLYAIDYSLWFQPYFPSPGVQYAPEKNFTFDGRASIQVEALVASDRFILNAYNFKIQSYKVVDIDGTVVPINSISQDDTTQQLSLITNANGVVAGQIYNIEFVYTGIINPYTDGGVYYTSYNDPQGNTHYMIATHMEPFSARKVFPSLDEPSYKAKFTITVQYPASQVALSNMMETEPTKIDNIWSTITFPQTPKMSSYLIAFAVGPYVNSQYVNKHNTLTRAWGWPGTEQYLQFAAQNAGECLYQLGEYTGIKFPLSKADQLGMPEFLAGAMENWGLIIYKYQYIAYNPTTMTTRNMEAAAKVMCHELAHQWFGDLVTTAWWDDLFLNEGFADYFMTFIQKSVYPQQATYLDTLQVLDELQVGLTADVRYDAHPLVYPDGPAFDDITYNKGASMLRMLSDVLGADVFKQGIRAYLQKMQYSNANDFDLFSTLTDTAKSNNILDWCGLPLNVTDFMQPYIHQTNHPLIRYNNNQKIGGSTFSQEPFLDISDLTATPWNYTWSIPLTSANLRHADPYKQWLPRQQGCANMNENIQEERIKEPNKRAVQWELTSITSATYGRIIYDDIGFDRILKLIKQDDINDNLKLTLLADEYNYMLREKKANRPFGYNRFLDLAKVIFNTQSFTNYPSYGVFAQAQPVLEQIAQLYRDGIDAEFVPRLYKLFFQNSYNQLKWQDTSIWDTDTFSEVFLPFAVRYDIGDVQNRTLNMFANVKSACINSLNGTAWCNPYSTNLRKAIYCGAAKYAPATSDYFFQMLHSYNKEVITNPYFYQEYMALLEGMSCTQSPATLKVLIRLFTTSTLNPSTIFGFLKYNPAASDVLYNYFMANPQLVNSTMLDAYLDAMTYNWNSYFREGQLSTLMNTLTLTNDQFDIFDFYINRVSLMFEYKSTYALPTYNWLYDNLVVIGKTPWEKTPNIDAVFPYYKLDLQVNIPGSGPYQWYENMTFSATSTVTFQLVSPTSSITINAHRLMFDPVSIRLYNENDENAHTPIPIDFSKVMKDYDKGTVTIPTMNNTVLYPNQYSLFIEYTGFIFQNPDEGDASNTYLGGLNNRKGWIFTTDFEGGPGARSLLPCWDEPSYKGQFEVSVFHPTDMIALSNEVDIQRTIYDNGWTTTKFATTNQMSTYLLALCVGHFSNLATVTRTGVLTRVWTWSGMEQYGEFALNVTAGTIDFMENYFSYDFPLKKLDVMALPEYTMNAGAMENWGLIIGEYSLFMFDPDYATTRDITEVAETTAHEVVHQWFGDIVTLDWWNDIFLNEGFAQYWFANGIDNTFPEQHAYSIDYNRFYMNHIALKYDCIPGVAKPVISDTPPVFGIEPYYKGSALLNLLNNVLTPAVFQEGLSSYLTQYGYVNASPRNLWTSLTVAAQRHNITDWNGQPLDVSSFMDPYTLQTSYPIITLTLRGTSTVQANQQSCMSDETLWNVPLFTQTPGALDFNWFVNFTGGNDATWLRPLPTGYRVDNAGSTSFARINYDDKSWYSIQAQLLSNMNTMSSTTRAMLLDDANFFYQSGRWEMTKFLDLTLYLVNEDSLAPWEQAIEFFTEMLNRFQYQPEIDTVRNYVIQITKNAVSKFQWNTNGLWANDRIVQLLVNVNNLAVNRQSRQVALTLFNNFVLKCKYSLSGTGKCSGIHPNLRQPTYCYGLRQSNNIDDFTTVNNLYSWFVQNAGYLQTDGSNLLNALGCVQNLDLQKTMLRSILSGDYPPSLLNSIAVHDDSSDVLYNFLLDNTQDILNAPFDFSLYVKAMFQNWSTSNQLELAKDFQNSSNYNLLNAAQKNIYKQGILTVNSNANWMLIYKTPFLEWIQKNFGAPNL
What is the function of this protein?
Putative aminopeptidase which plays a role in oocyte maturation.
What are the official names of this protein?
Putative aminopeptidase-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
Protein: RS4_LEGPC
Sequence: MARYLGPKCKLSRREGCDLLLKSGVRDHKSKCKSEKLPGQHGDKKPRLNSYGIQLREKQKIRRLYGILEKQFRNYYKKAARQKGSTGENLMALLERRLDNVVYRMGFASTRAEARQLVAHKAILVNDKVVNVPSFLVNPGDTVSVRQKAKNQGRIQAALALSEQRAPCDWITVDTGSFKGTFSTAPTLMDLSSDYNVNLVVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PETG_GNEPA
Sequence: MVETLLSGIVLGLVPITLAGLFVTAYLQYRRGDRLDI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: YWPJ_BACSU
Sequence: MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRAHFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYEVFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQELFEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQALKRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHGVAHMMKHLL
What is the function of this protein?
Catalyzes the dephosphorylation of phosphorylated 5-6 carbon sugars and monophosphate nucleotides (NMP) in vitro (By similarity).  To a lesser extent, dephosphorylates flavin mononucleotide (FMN) in vitro (PubMed:26316208).
What are the official names of this protein?
Phosphatase YwpJ.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: KTHY2_SACS2
Sequence: MRGLLIAFEGIDGSGKSSQAVLLKDWIEMRRDVYLTEWNSSEWIHDIIKEAKKKNMLTSITFSLIHATDFSDRYERYILPMLKSGFVVICDRYVYTAYARDVVRNVDFDWVKRLYSFAIKPNFTFYIRVTPEIALERIRKAKRKIKPQEAGIDILGEIPLEEGFLKYQSRIVEIYDKIAKEESNFITIDGNRPLKDVQIDIRKILGEYIDNSL
What are the official names of this protein?
Probable thymidylate kinase 2, dTMP kinase 2.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: LEUC_ENT38
Sequence: MARTLYEKLFDAHVVYEASNETPLLYIDRHLVHEVTSPQAFDGLRAHNRQVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCNAFGVELYDLNHPFQGIVHVMGPEQGITLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVKGHAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGDAIRALSMEGRMTLCNMAIEMGAKAGLVAPDDITFNYVKGRLHAPKGNDFDDAVEYWKTLQTDEGATFDTVVTLQAEEIAPQVTWGTNPGQVISVNDNVPDPASFADPVERASAEKALAYMGLKPGIPLTEVAIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRVLK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.