PharMolix/UniProtQA huggingface dataset:
Protein: STP1_LISW6
Sequence: MHAEFRTDRGRIRHHNEDNGGVFENKDNQPIVIVADGMGGHRAGDVASEMAVRLLSDAWKETTALLTAEEIETWLRKEIQEVNKQIVLYAESEMDLNGMGTTLVAAIMAKSQVVIANVGDSRGYLLQNNTLRQLTEDHSLVHELLRTGEISKEDAMNHPRKNILLRALGVEGKVEVDTFVVPFQTTDTLLLCSDGLTNMVPETEMEDILKSKRSLSEKADVFITKANSYGGEDNITVLLVERNLMQKGRDAS
What is the function of this protein?
Protein phosphatase that dephosphorylates EF-Tu.
What are the official names of this protein?
Serine/threonine phosphatase stp.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: DNLJ_PSEP1
Sequence: MTAETRILELRAELDQHNYRYYVLDEPSVPDAEYDRLFNELKALEAEHPHLVTPDSPTQRVGGAALAAFSQVRHEVPMLSLGNAFEEADLREFGRRVVEGLDQPGAVDYSCEPKLDGLAVSLLYRDGQLVQGATRGDGTTGEDISANVRTVRNIPLKLQGKGWPAVLEVRGEVYMSKAGFDRLNAAQAEAGGKTFANPRNAAAGSLRQLDSKITASRPLEFCCYGVGQLSESIGDSHIGILEQLKAWGLPISRELKHAAGIEECLAYYRDIGERRNSLPYEIDGVVFKVNSLAAQRELGFRAREPRWAIAHKFPAMEELTEVLDVEFQVGRTGAVTPVARLKPVKVAGVTVSNATLHNMDEIARLGLRIGDTVIIRRAGDVIPQVMQVVLERRPQDARPVEVPSECPVCGSQVERTQLVKRSKGKETTSEGAVYRCVGRLACGAQLKQAIIHYVSRRAMDIDGLGEKSVEQLVDEGLIGSPADLYKLQFEQVVGLEGFAEVSTQKLLDAIEASKRPSLARFIYALGIPDVGEETAKVLARSLGSLARVQQALPQVLTYLPDIGLEVAYEIHNFFEDEHNQKVIQQLLDSGMQLQDEGELAAEFAASTTLAGMIAKLDIASVGPTGAEKLVAKLDSLDKIIAADGIDLRQALAAKQADAVREFFKDEANQKLARDIEAQLLAFGMHWSSEKKVAEGLPLAGQTWVLTGTLERMSRDIAKDKLESLGAKVAGSVSGKTHCVVAGPGAGSKLAKAAELGVKVLDEDAFVTFLAEQGIAV
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RL16_DESPS
Sequence: MLSPKKVKHRKVFKGRMRGAAHRGSSLAFGDYALKALSCGTMTARQIEAARITINRTMKRGGQVWIRVFPDKPLTKKPAETRMGKGKGSPESWVAIVKPGRLLYEVAGVSEDVAIKALSLASNKLPFPCKVVTRRTTL
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: PSAJ_COFAR
Sequence: MRDFKTYLSVAPVLSTLWFGALAGLLIEINRFFPDALTFPFFSF
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MD1L1_HUMAN
Sequence: MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA
What is the function of this protein?
Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas.
What are the official names of this protein?
Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, MAD1-like protein 1, Mitotic checkpoint MAD1 protein homolog, HsMAD1, hMAD1, Tax-binding protein 181.
What is the protein family that this protein belongs to?
Belongs to the MAD1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Co- localizes with TPR at the nucleus envelope during interphase and throughout the cell cycle (PubMed:22351768, PubMed:18981471). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody (PubMed:9546394). Localizes to kinetochores during prometaphase (PubMed:22351768, PubMed:29162720). Does not localize to kinetochores during metaphase (PubMed:29162720). Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle poles during metaphase and anaphase (PubMed:22351768). SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Protein: SKPL_CHLMU
Sequence: MKKFLLLSLMSLASSTVFAASSTNTIGIVNLRRCLEESELGKKESAEFEKMKNQFSNSIGKMEEELSSIYSKLQDDDYMEGLSESAAAELRKKFEELSSEYNTAQGQYYQILNQNNLKRMQKIMEAVKKASEVVRIQEGLSALLNEDIVLAIDTSSDKTDAVIKILDDSFQNN
What are the official names of this protein?
Skp-like protein.
What is the protein family that this protein belongs to?
Belongs to the Skp family.
Protein: Y535_UREPA
Sequence: MKKSFLIMTDSSTTLDREWAKNNDVMILPLSILRSDHTLIVDDGIESKPERIYEDIDNGYTFQTSCTPYGVLIEAIEQKLQEYEKIIFIGISSGFSSQFNNAKNLEKEYQDKLFVVDTEDFGYSLEHLVYKIKAMLSNNISFGDILKMINKHHDYTSSFLACENITGLVRSGRIPKIIGTMLKLSKVTPIIKAEWKNHRAGMALNIRSAPHKILENINHVFDNQLNNHTIEKVCILQAGLSSERIDELKNDVINHFHVDKEKIVIRSGPPIFLVYVWKGALGIQVIANIPKKHVEKKH
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein UU535.
Protein: NAT2_YEAST
Sequence: MMVPRISASPVFKRIFLRWGFVTLPIQKTVSHTLRRDFSAPCRSMVKCLLLRPGISVHSAQDRKFYSTEEKSSQFDENKSKSNNGKKNEPHGIKGLMAKYGYSALIVYILLTCVDLPLCFLGVHSLGEEKIKIYLNRGKQLIGMGEPDESKVIQDVRRKQAHREAVQAENADKVEDASRKTFNERWQEMKDSTLLAELLIAYGIHKSLIIVRVPLTAVLTPSFVKLLQRFGIDLMKKQKKVFQTMASGAKIRYKGNNPSDFIKNEGTALDITKRKPRTKGQKWFDGLM
What is the function of this protein?
Maybe involved in N-terminal acetylation of proteins.  N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover.
What are the official names of this protein?
Putative N-terminal acetyltransferase 2, Amino-terminal, alpha-amino, acetyltransferase 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMW_ECOLI
Sequence: MVKLPPLSLYIHIPWCVQKCPYCDFNSHALKGEVPHDDYVQHLLNDLDNDVAYAQGREVKTIFIGGGTPSLLSGPAMQTLLDGVRARLPLAADAEITMEANPGTVEADRFVDYQRAGVNRISIGVQSFSEEKLKRLGRIHGPQEAKRAAKLASGLGLRSFNLDLMHGLPDQSLEEALGDLRQAIELNPPHLSWYQLTIEPNTLFGSRPPVLPDDDALWDIFEQGHQLLTAAGYQQYETSAYAKPGYQCQHNLNYWRFGDYIGIGCGAHGKVTFPDGRILRTTKTRHPRGFMQGRYLESQRDVEATDKPFEFFMNRFRLLEAAPRVEFIAYTGLCEDVIRPQLDEAIAQGYLTECADYWQITEHGKLFLNSLLELFLAE
What is the function of this protein?
Probably acts as a heme chaperone, transferring heme to the NarI subunit of the respiratory enzyme nitrate reductase; transfer may be stimulated by NADH.  Binds one molecule of heme per monomer, possibly covalently.  Heme binding is not affected by either [4Fe-4S] or S-adenosyl-L-methionine (SAM)-binding.  Does not have coproporphyrinogen III dehydrogenase activity in vitro (PubMed:29282292).  Binds 1 [4Fe-4S] cluster.  The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Probable).
What are the official names of this protein?
Heme chaperone HemW.
What is the protein family that this protein belongs to?
Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDTI_ECO57
Sequence: MAQFEWVHAAWLALAIVLEIVANVFLKFSDGFRRKIFGLLSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWILFGQRLNRKGWIGLVLLLAGMIMVKLA
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtI.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PGK_STRS7
Sequence: MAKLTVKDLDLKGKKVLVRVDFNVPLKNGVITNDNRISAALPTIKYIIEHGGRAILFSHLGRVKEEADKEGKSLAPVAKNLAEKLGQEVIFPGSTRGAELEAAIDALEDGQVLLVENTRFEDIDGKKESKNDPELGKYWASLGEGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIKEAVEAPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLCEEDKLDVAKSLLEKSNGKLILPVDSKEANAFADYTEVKVTEGEAVDAGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQEGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKELPGLAALTEK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DMP1_BOVIN
Sequence: MKTTILLMFLWGLSCALPVARYQNTESKSSEEWKGHLAQTPTPPLESSESSEESKLSSEEQANEDPSDSTESEEVLGLDDQQHVHRPAGGLSRRGGSEGDNKDDDEDESGDDTFGDDDGGPGPEERRSGGDSRLGSDEDSADTTRSREDSTPQGDEGARDTTSESRDLDREDEGNSRPEGGDSTPDSDSEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPGAYRSERGNSRISDAGLKSTQSKGDDEEQASTQDSHESPAAAYPRRKFFRKSRLPEEDGRGELDDSRTIEVMSDSTENPDSKEAGLGQSREHSKSESRQESEENRSPEDSQDVQDPSSESSQEVDLPSQENSSESQEEALHESRGDNPDNATSHSREHQADSESSEEDVLDKPSDSESTSTEEQADSESHESLRSSEESPESTEEQNSSSQEGAQTQSRSQESPSEEDDGSDSQDSSRSKEDSNSTESVSSSEEEAQTKNTEVESRKLTVDAYHNKPIGDQDDNDCQDGY
What is the function of this protein?
May have a dual function during osteoblast differentiation.  In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin.  During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).
What are the official names of this protein?
Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity).
Protein: NU3M_PERSL
Sequence: MNMLTVLSVNIALSTCLITIAFWLPQLNLYTEKANPYECGFDPMSSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQMNNINTMMLTAFILVSVLALGLAYEWMQKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SYL_TREPA
Sequence: MGYPFRALEKKWQAYWRDKRVFCVSEDERFPPERRAYVLDMFPYPSAQGLHVGHPEGYTATDIYCRYLRMGGYNVLHPMGFDAFGLPAENFALKTGTHPRVSTSANCDTFRRQIQSFGFSYDWEREISTADPEYYRWTQWLFLKLYEKGLAYEATAPINWCPSCKTGLANEEVRDACCERCGAEVTRRGVRQWMVRITAYAERLLSDLDELDWPESVKQMQRNWIGKSCGAEIDFPVDAPACSVHDKLPQTIRVYTTRADTLFGVTYLVLAPEHEAVTALTTHAQRAAVQAYVQRAAKKNDLERTDLAKEKTGVFTGAYVRNPINDMRIPVWVGDYVLVSYGTGAVMAVPAHDQRDWDFATRFGLPKLTVVSADYTATVPNSNSPQGAVLQRCVSDEGFVVNSGAFNGLASADARERIVAHLEMRGAGARRVTYRLRDWVFSRQRYWGEPIPLVHCPSCGVVPLPESALPLLLPETADFTPTEDGQGPLARARTWLRVPCPQCASDAVRETNTMPQWAGSCWYYLRYMDPRNKTAFCAPEKERYWAPVALYVGGAEHAVLHLLYARFWHKVLYDLGLVSTKEPFARLVNQGMITSYAYRRKNGALVPHDEVHTNAQGTYVHARTGEKLECVVAKMSKALKNVVNPDDMIAAYGADACRVYEMFMGPLEASKPWNTQGLVGVFRFLEKIWVLAGRVAAANGIPQDSRAEPPGDLHAQKKSCSMYALETLLHRTIQKVTDDTSALSFNTAISQMMIFVNEATRVARRMPLPSKMWEMFVKILSPYAPHLAEELWEMCGHTHTIAYEPWPQVDPARVAPHVCSVVVQVNGKVRDTFSVAPNAPNEELEQKARETAGARKFLGTQQPKRVVIVPNKLVNFVL
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCF23_BOVIN
Sequence: MSQREARGARAMPGLGQSPAKATPRLLAGTERKRSRLSRRGQDLWEESSWSNQRWSRTAPNPRGARARSLARGRSEASPENAARERSRVRTLRQAFLALQATLPAVPPDTKLSKLDVLVLATSYIAHLTRTLGQEMPGPSWPPFLRGLRYLHPLKKWPMRSRLYAGGLGCSGLDSTTASNSGQRTKEAEAGPHVSGEPDALLSTRQLSPAPSDK
What is the function of this protein?
Inhibits E-box-mediated binding and transactivation of bHLH factors.  Inhibitory effect is similar to that of ID proteins.  Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers.  Lacks DNA binding activity.  Seems to play a role in the inhibition of myogenesis (By similarity).
What are the official names of this protein?
Transcription factor 23, TCF-23.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOA_NOVAD
Sequence: MTVNIKNWQELKKPNNLEIKPGNDSKRRATFVAEPLERGFGLTLGNALRRVLLSSLQGAAVTSIKIENVLHEFSSLAGVREDVTDIVLNVKQIALKMQGEGPKRLQLSATGPGEVKAGDIAVTGDIEVMNKDLVICHLDEGATFNMELTVDTGKGYVPAVSNRPVDAPIGLIPVDSLYSPVRQVSYKVENARIGQELDYDKLNLTVETDGTVTPEDAVAYAARILQDQLALFVHFDDQVPVGHVPMVAGVPAHAPEESDANQLNRYLLKKVDELELSVRSANCLKNDNIIYIGDLVQKTEAEMLRTPNFGRKSLNEIKEVLSSMGLRLGMDIPGWPPENIEEMAKKLEQELLG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: CUEA_CONAX
Sequence: SCGYPCSHCGIPGCYPG
What is the function of this protein?
May have neurotoxic activities (Probable).  Does not show any effect on voltage-gated potassium channels (10 uM of toxin tested), and on nicotinic acetylcholine receptors (5 uM of toxin tested) (PubMed:27801785).  Does not show antibacterial activity on both Gram-negative and Gram-positive bacteria (PubMed:27801785).
What are the official names of this protein?
Conotoxin Asi14a.
What are the subcellular locations of this protein?
Secreted.
Protein: AROK_CHLCH
Sequence: MQKEPSLIFLTGFSGSGKSTIGPLLANSLGYEFVDLDALIERECGKSINQIFAEAGEAAFRQHEEQTLETLLMRRKTVVSLGGGVLEQPRAFELVRQAGTVVYLKSPVKTLARRLSNKTDRPLLKGEQGEKLSQEEIEQKIAELLARREPRYECADITVETDAKRIGSTVEELTRKIERYMRTLALSSEE
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYRF_MOUSE
Sequence: MEVVDETEALQRFFEGHDISGALEPSNIDTSILEEYIGKEDASDLCFPEISAPASTASFPHGPPAIPGSSGLHHLSPPGSGPSPGRHGPLPPPTYGTPLNCNNNNGMGTAPKPFLGGSGPPIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNDPHLLRTITPETLCHVGVSSRLEHPPPPPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPVPPYAAMGPGLVPPELHHTQQTQVLHQLLQQHGAELPPHPSKKRKHSESPPNTLNAQMLNGMIKQEPGTVTALPPHPARAPSPPWPPQGPLSPGTGSLPLSIARAQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNKWATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTPEGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESDSDVLWQRAQLPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDTTEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDVVFANGKTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGSSGAFSHAGSQFSRAGSVPHKKRPPKLANKSSPAVPDQACISQRFLQGTIIALVVVMAFSVVSMSTLYVLSLRSEEDLVDADGSLAVSTSCLLALLRPQDPGGSEAMCPWSSQSFGTTQLRQSSMTTGLPGTQPSLLLVTKSASGPALRALDLCSSQPCPIVCCSPPVSSPATDPALGPTLTPTPSPSSNPKHSGPGQMAPLPVTNIRAKSWGISANGISYSKHSKSLEPLASPVVPFPGGQSKTKNSPSFNLQSRARRGAPQPSPSPAQFTQTQGQLDPAPSLTSIQLLENSMPITSQYCVPEGACRLGNFTYHIPVSSSTPLHLSLTLQMNSSTPVSVVLCSLTSEEEPCEEGGFLQRFHPHQDTQGTSHQWPVTILSFREFTYHFRVTLLGQANCSSEAIVQPATDYYFHFYRLCD
What is the function of this protein?
Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:19596243, PubMed:22956843, PubMed:23966833, PubMed:24204311, PubMed:27532821).  Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression.  Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:19596243, PubMed:22956843, PubMed:23966833).
What are the official names of this protein?
Myelin regulatory factor, Myelin gene regulatory factor.
What is the protein family that this protein belongs to?
Belongs to the MRF family.
What are the subcellular locations of this protein?
[Myelin regulatory factor]: Endoplasmic reticulum membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: [Myelin regulatory factor, N-terminal]: Nucleus. Cytoplasm. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage. SUBCELLULAR LOCATION: [Myelin regulatory factor, C-terminal]: Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: NRG2_RAT
Sequence: MRQVCCSALPPPLEKARCSSYSYSDSSSSSSSNNSSSSTSSRSSSRSSSRSSRGSTTTTSSSENSGSNSGSIFRPAAPPEPRPQPQPQPRSPAARRAAARSRAAAAGGMRRDPAPGSSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCAPLERNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGEVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLHVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRRQMHHHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRREAETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYSQEERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGADMQRSYDSYYYPAAGPGPRRGACALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRTRGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGCGSASASDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPTRAKQDSGPL
What is the function of this protein?
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors.  Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.  May also promote the heterodimerization with the EGF receptor.
What are the official names of this protein?
Pro-neuregulin-2, membrane-bound isoform, Pro-NRG2.
What is the protein family that this protein belongs to?
Belongs to the neuregulin family.
What are the subcellular locations of this protein?
[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. SUBCELLULAR LOCATION: [Neuregulin-2]: Secreted.
Protein: YIDD_ENDTX
Sequence: MKQIALFLIKCYKFISQFLPSICRFQPSCSTYAYQAIETYGFFKGSLLTFKRIIRCRPFCAGGFDPVPLPKKKI
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL20_BURP0
Sequence: MPRVKRGVTARARHKKIINLAKGYRGRRNNVYRIAKQAVMRAGQYAYRDRRNKKRVFRALWITRINAAVRQHDMTYSVFINGLKKASIELDRKVLADMAVFDKAAFAAIVKQVKAAVAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: KDSB_SHEFN
Sequence: MKVTLLIPARYGSSRFPGKPLAPINGKPMIQHVYERASLAKGLDSIYVATDDDRIKDAVESFGGKVVMTSPDAASGTDRINDAIALLGLNDDDLVINLQGDQPLIDPISIEQIISLFERHPGEFEMATLGFEIVDKRELDDPMHVKMVFDNDHNALYFSRSRIPFGRDTNDYPVYKHLGVYAYTKRFVNAFAKLPLGRLEDLEKLEQLRALEYGHKIKIAISAFDSPEVDTPEDIRKCELRLAVD
What is the function of this protein?
Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus.
What are the official names of this protein?
8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase, CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_TRIV2
Sequence: MMVNDIEYIRQAEATRVQVLSEALPYIQQFAGRTVVVKYGGAAMKDSHLKDQVIRDIVFLSCVGLRPILVHGGGPEINSWLDKLGIEAQFKNGLRVTDAPTMDVVEMVLVGRVNKEIVSLINQAGGLAVGLCGKDGNLITARPQGQEGIGFVGEVSNVNIKILETLASNGYIPVVSSVAADDSGQAYNINADTVAGEIAAALGAEKLILLTDTRGILKDYKDPGTLIPKVDIREARELINGGVVSGGMIPKVTCCVRSLAQGVRAAHIIDGRIPHALLLEIFTDVGIGTMILGSQYS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABCC8_CRICR
Sequence: MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTESRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIAKLPIAMRALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHMSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLAPSMDGDADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSNLPDSEGEDPSSPERETAAGSDIRSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKASEPSQGLPRAMSSRDGLLLDEEEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECDLDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLVSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVCMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFASFVRADK
What is the function of this protein?
Subunit of the beta-cell ATP-sensitive potassium channel (KATP).  Regulator of ATP-sensitive potassium channels and insulin release.
What are the official names of this protein?
ATP-binding cassette sub-family C member 8, Sulfonylurea receptor 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.