PharMolix/UniProtQA huggingface dataset:
Protein: PRIO_PONPY
Sequence: MANLGCWMLVLFVATWSNLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: BORC8_DANRE
Sequence: MEDQEMQLKVKRVTDKFTESMYVLANEPSIALYRLQEHVRRSLPELVQHKTDMQSWEEQSQGAIYTVEYACSAVKSMTNSSLYFKNIDGLLRQAISLKEQISSSQGRSAVINPNETPAHTSVTP
What is the function of this protein?
As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery.  Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
What are the official names of this protein?
BLOC-1-related complex subunit 8.
What is the protein family that this protein belongs to?
Belongs to the BORCS8 family.
What are the subcellular locations of this protein?
Lysosome membrane.
Protein: FDB40_GIBM7
Sequence: MASPTISSMEQYTPSSKDEKIVPLHGDAAGSDTEKGESREVFQENVDGVEFRTVSWQRATVVFLKINFAMSILAIPGALGALGSVGGSLCIVGYTSLNVYTALVLGDFKHNHTECHTLADMMGLIWGRWGRELVGVQIIVAQVLISAGGIVTSAIGLNALSDHGTCTVMFALVSAILITLFSSIRTFARLGWLTWFGFITFVLGVFIFVVAVTQVDRPAAAPKTGDFELGWAPIAYPSFVVGMINATNIFISTCGSSMFLPVISEMKRPHDYRKACLVAGFIVGAMYLSFSLVIYRWCGTWISTPAFGSAGPLIKKVAYGVSLPGLILGVGIYQHVAAKYAFVRILRDSEHLQANTFTHWGTWLGINLALGTAAFIVAEAVPILNYLLGLAGSLCFAPFSLVFPALLWMYDFKSYKTGTLGQKIKYGLHILIMILGFYMIVAGTYSVAVLIKEAFNTGAIAKVFDCADNSGFVQ
What is the function of this protein?
Transmembrane transporter; part of the Fusarium detoxification of benzoxazolinone cluster 2 (FDB2) involved in the degradation of benzoxazolinones produced by the host plant (PubMed:26808652).  Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).  Might be involved in the transport of metabolites of benzoxazolinone degradation (Probable).
What are the official names of this protein?
Transmembrane transporter FVEG_12640, Fusarium detoxification of benzoxazolinone cluster 2 protein FVEG_12640, FDB2 cluster protein FVEG_12640.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GLMU_ALISL
Sequence: MNFSAVILAAGKGTRMYSNKPKVLHTLAGKPMAKHVIDTCEGLGAKNIHLVYGHGGDQMQAELGQERVTWVLQAEQLGTGHAVNQASPEFSDDEKVLILYGDVPLISTATVENLLDAQPTGGIALLTVVLDNPMGYGRIIRRNGPVIAIVEQKDATEEQKLIKEINTGVMVATGGDLKRWLAALKNENAQGEYYLTDIIAAAHDEGRAVEAVHPVSPIEVEGVNDRAQLARLERAYQAAQAQKLLEQGVMLRDPSRFDLRGSLQCGMDIEIDVNVIIEGNVTLGDNVVIGAGCVLKDCEIDDNTIIRPYSVIEGATVGEKCTVGPFTRLRPGAELCNDAHVGNFVEVKNVRLGEGSKANHLTYLGDAEIGKRVNVGAGVITCNYDGANKFKTIIGDDVFVGSDSQLIAPVTIGNGATIGAGSTVTKDVAENELMISRAKERRIEHWQRPTKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_SYNE7
Sequence: MVASSSLPRLLRAARGEVLDRPPVWMMRQAGRYMKVYRDLRDKYPGFRERSETPELAIEISLQPFRAFKPDGVILFSDILTPLPGMGIPFDIIESKGPILEPPIRTAEQVAAVHDLDPEEATPFIRPILETLRQEVGNEAAVLGFAGAPWTLAAYAIEGKSSKTYANIKHLAFSEPTILHELLGKLADNIAIYLCHQIDCGAQVVQLFDSWAGQLSPIDYDTFALPYQQRVFQQVKAKHPEVPLILYISGSAGVLERMGQSGCDIVSVDWTVDLLDARRRLGPDIGLQGNIDPGVLFGSQDFIRDRILDTVRKAGNQRHILNLGHGILPGTPEDNARHFFETAKNLDQLLAASH
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_HAHCH
Sequence: MKLDDIRREYLYAGLSRKDLADDPIVQFKNWLQTAIDADLNADPTAMSLATVNAQGVPSQRIVLLKNLDPSGFVFYTNLGSRKAQNIAENANVSLHFAWLPMERQICVTGVAEKLSIAEATRYFLSRPHESQVAAWASQQSQGIGSRKLLEQAFEQMKNRFKQGEVPLPSFWGGYRVKPVTIEFWQGRANRLHDRFLYKKTDENWEIERLQP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: MPSIN_IXOSC
Sequence: MKSLLVCLVLAVVVLVASGHHVELCKKNDAELKEALTCITSKLPAALGCNDKSCVFEKLCKEGDLDEALKKHFTEAEVQTLHTTATDCDHSHGHEHSHGHEHGHGHH
What is the function of this protein?
Has bacteriostatic activity against Gram-positive bacteria, but not against Gram-negative bacteria.  Has fungistatic activity against some but not all fungi.  Binds and sequesters copper and iron ions.  Copper-chelating is crucial for antimicrobial activity against M. luteus (By similarity).
What are the official names of this protein?
Antimicrobial peptide microplusin.
What are the subcellular locations of this protein?
Secreted.
Protein: MHPB_MYCGI
Sequence: MAKSQIALCCMSHSPLLNLPGPAQELLDEIDKAIAAARDFVAEFDPELVVTFSPDHYNGFFYRAMPPFCIGTAAEGVGDYGTHEGPLDVPSDLATDCARAVLDHDVDVALSAAMDVDHGTVQPLQKLFGDATAKPVIPVFINSVATPLGPIRRVRALGAAVGAHLATLGKRVLVIGSGGLSHDPPVPTLATAPPAALDRIVRGVPMTTDQRQARQTAVIEAAREFASGRGTLAPLNPDWDRAFLDIVDSGRLAEVDGWDNGWIAEQAGNSAHEVRTWIAAFAALAAQGEYVTENRFYRAAPELIAGFAIRTAVTT
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: RAIR_RHIET
Sequence: MSPSHAEQFSFFLLSGPDLRIADIAGSGNDAGRSRPHLCDIAYGSPCDLAGATDSNPLLMLTYPPEWVKQYRDRDYFSIDPVVRLGRRGFLPVEWSASGWDSGRAYGFFKEAMAFGVGRQGVTLPVRGPQGERSLFTVTSNHPDAYWRQFRMDSMRDLQFLAHHLHDRAMVLSGMRKVADLPRLSRRELQCLEMTANGLLAKQICARLSISVSAVQLYLASARRKLTVATTSEQLLGPRRSN
What are the official names of this protein?
Transcriptional activator protein RaiR.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-regulated transcriptional regulatory protein family.
Protein: DYR_PIG
Sequence: VRPLNCIVAVSQNMGIGKNGDLPWPPLRNEYKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLTEQPELKDKVDMVWIVGGSSVYKEAMNKPGHIRLFVTRIMKEFESDTFFPEIDLEKYKLLSECSGVPSDVQEEKGIKYKFEVYEKNN
What is the function of this protein?
Key enzyme in folate metabolism.  Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.  Binds its own mRNA and that of DHFR2 (By similarity).
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: LEUD_RUEPO
Sequence: MEKFTKIQGIAAPMPLVNIDTDMIIPKVFLKSIQRTGFGKNLFDEMRYNRDGTEIPDFVLNKPQYRDAEILVAGDNFGCGSSREHAPWAIADFGIKCIISTSFADIFFNNSFKNGILPIVLPQEQVDILMKDAEKGANARMTVDLEAQEITTSDGEVIPFEVDAFKKHCLLNGLDDIGLTMEKAAAIDTFEAQAAQARPWV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: KDSA_SYNPW
Sequence: MAARQVSLGSITFANDAPFVLIGGVNVLESQQFALDAAAVYADVCRRLSIPLVFKASFDKANRSSIHSFRGPGLSDGLAMLQAVKDTHGIPVITDVHTPEQAAPAAEVCDIIQLPAFLARQTDLVQAMAGTGAVINIKKPQFLSPSQMANVVEKFRECGNEQLLICERGSNFGYDNLVVDMLGFGVMKRCCDDLPLIFDVTHALQCRDPGGAASGGRRSQVLDLARAGMAVGLAGLFLEAHPDPSQARCDGPSALPLHQLEPFLSQLKAVDDLVKSLPALTIQ
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_HELPY
Sequence: MTNFEKIIAQNRIKTNAVLATYCVIFAFIGLLVDVIRINANDLGIALFKLMTFQIFPTITMIMFLVAFVVIVVCIQNFSSIMLSGDGYKLIDTSKVLSSKENQIHRLLLELLEEANLHFEPKLYIINAPYMNAFASGWNESNSLIALTSALIERLDRDELKAVIAHELSHIRHNDIRLTMCVGILSNIMLLVANFSVYFFMGNRKNSGANLARMILWVLQIILPFLTLLLQMYLSRTREYMADSGAAFLMHDNKPMIRALQKISNDYTNNDYKEIDKNSTRSAAYLFNAEMFSTHPSIKNRIQSLRKRVI
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PNCB_ECOSM
Sequence: MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDLLGIYADAIREQVQAMQHLRLQDDEYQWLSALPFFQADYLNWLREFRFNPEQVTVSNDNGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQTDVAQALDTLESKLVDFSALTAGLDMSRFHLMDFGTRRRFSREVQETIVKRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQRAALAAWLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLGIDPQSKTLVFSDNLDLRKAVELYRHFSSRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPHIKKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: TPPC4_MOUSE
Sequence: MAIFSVYVVNKAGGLIYQWDSYSPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGMDVNGKYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCFQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS
What is the function of this protein?
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase.  Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (By similarity).  May play a role in dendrite postsynaptic membrane trafficking (PubMed:11018053).
What are the official names of this protein?
Trafficking protein particle complex subunit 4, Synbindin, TRS23 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane. Golgi apparatus membrane. Endoplasmic reticulum. Vesicle. Note=Associated with postsynaptic membranes and in intracellular cisterns and vesicles (Golgi).
Protein: MUG_ECOLU
Sequence: MVEDILAPGLRVVFCGINPGLSSAGTGFPFAHPANRFWKVIYQAGFTDRQLKPQEAQHLLDYRCGVTKLVDRPTVQANEVSKQELHAGGRKLIEKIEDYQPQALAILGKQAYEQGFSQRGAQWGKQTLTIGSTQIWVLPNPSGLSRVSLEKLVEAYRELDQALVVRGR
What is the function of this protein?
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base.  The complementary strand guanine functions in substrate recognition.  Required for DNA damage lesion repair in stationary-phase cells.
What are the official names of this protein?
G/U mismatch-specific DNA glycosylase, Double-strand-specific uracil glycosylase, Mismatch-specific uracil DNA-glycosylase, MUG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRGB_STAAN
Sequence: MINHLALNTPYFGILLSVIPFFLATILFEKTNRFFLFAPLFVSMVFGVAFLYLTGIPYKTYKIGGDIIYFFLEPATICFAIPLYKKREVLVKHWHRIIGGIGIGTVVALLIILTFAKLAQFANDVILSMLPQAATTAIALPVSAGIGGIKELTSLAVILNGVIIYALGNKFLKLFRITNPIARGLALGTSGHTLGVAPAKELGPVEESMASIALVLVGVVVVAVVPVFVAIFF
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB.  The LrgAB and CidAB proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. LrgB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OHRL_STAAN
Sequence: MAIHYETKATNVGGRKGHVYTDDRALDIDIVPPAQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAHPEVTLTVRLEDDSDSESPKLSVSIDATIKNVISQEEAEKYLQMAHEFCPYSKATQGNINVDLNVNVVD
What are the official names of this protein?
Organic hydroperoxide resistance protein-like.
What is the protein family that this protein belongs to?
Belongs to the OsmC/Ohr family.
Protein: HIS82_NITEU
Sequence: MMNLSELAPDYIRAIQPYQPGKPISELVRDLGLNKDEVVKLASNENPLGTSPLAKEAMIQALNESARYPDGSGFELKAALSERLGMPADQIVLGNGSNDVLELATRIFLHPDSTAIYSQYAFAIYPLLAQAVGARGIAVPARNYGHDLEAMLAAVTPETRIIFIANPNNPTGTLCDARDLLRFMERVPQDVLVILDEAYDEYLPEANKANSIAWLKNFQNLVITRTFSKAYGLASVRVGFALAHADIANLMNRIRQPFNVNSIGLAAAQAALKDVEFVKLAYMTNRTGMQQMTHGLDQLGIEYIPSFGNFVCCHIDGHPANTLKIYRNLLQQGVIVRPLGNYDMLNHLRVTIGIEEENKRFLQALEQALKELD
What are the official names of this protein?
Histidinol-phosphate aminotransferase 2, Imidazole acetol-phosphate transaminase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: YTPB_BACSU
Sequence: MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDFRMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLLELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVAYSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMMDRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC
What is the function of this protein?
Catalyzes the transformation of a linear C35 prenyl diphosphate chain to form tetraprenyl-beta-curcumene.
What are the official names of this protein?
Tetraprenyl-beta-curcumene synthase.
What is the protein family that this protein belongs to?
Belongs to the large terpene synthase family.
Protein: DNLI1_RAT
Sequence: MQRSIMSFFQPTTTEGKAKKPEKEIPSSIREKEPPPKVALKERNRAVPESDSPVKRPGRKVAQVLSSEGEDEDEAPGTPQVQKPVSDSKQSSPPSPDSCPENSPVFNCSPSMDISPSGFPKRRTARKQLPKRTIQDTLEEPNEDKAKAVKKRKKEDPQTPPESLTEAEEVNQKEEQVEDQPTVPPEPTESPESVTLTKTENIPMCKAGVKQKPQEEEQSKPPARGAKPLSSFFTPRKPAVKTEVKQEESDTPRKEETKGAPDPTNYNPSKSNYHPIEDACWKHGQKVPFLAVARTFEKIEEVSARLKMVETLSNLLRSVVALSPTDLLPVLYLSLNRLGPPQQGLELGVGDGVLLKAVAQATGRQLESIRAEVAEKGDVGLVAENSRSTQRLMLPSPPLTVSGVFTKFCDIARLTGSASMAKKMDIIKGLFVACRYSEARFIARSLSGRLRLGLAEQSVLAALAQAGSLTPPGQEFPTVVVDAGKGKTAEARKMWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLESLPEHCKLSPGVPLKPMLAHPTRGVREVLKRFEEVDFTCEYKYYGQRAQIHVLEGGEVKIFSRNQEDNSGKYPDIISRIPKIKHPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLARQPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLEGVGDTLDLVVIGAYLGRGKRPGRYGGFLLAAYDEESEELAAICKLGTGFSDEELEEHHQNMQALLLPTPRPYVRIDGAVAPNHWLDPSIVWEVKCADLTLSPIYRAARGMVDKEKGISLRFPRFIRVREDKQPEQATTSDQVASLYRKQSQIQNQQSSDLDSDVEDY
What is the function of this protein?
DNA ligase that seals nicks in double-stranded during DNA repair.  Also involved in DNA replication and DNA recombination.
What are the official names of this protein?
DNA ligase 1, DNA ligase I, Polydeoxyribonucleotide synthase [ATP] 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KRT37_HUMAN
Sequence: MTSFYSTSSCPLGCTMAPGARNVFVSPIDVGCQPVAEANAASMCLLANVAHANRVRVGSTPLGRPSLCLPPTSHTACPLPGTCHIPGNIGICGAYGKNTLNGHEKETMKFLNDRLANYLEKVRQLEQENAELETTLLERSKCHESTVCPDYQSYFRTIEELQQKILCSKAENARLIVQIDNAKLAADDFRIKLESERSLHQLVEADKCGTQKLLDDATLAKADLEAQQESLKEEQLSLKSNHEQEVKILRSQLGEKFRIELDIEPTIDLNRVLGEMRAQYEAMVETNHQDVEQWFQAQSEGISLQAMSCSEELQCCQSEILELRCTVNALEVERQAQHTLKDCLQNSLCEAEDRYGTELAQMQSLISNLEEQLSEIRADLERQNQEYQVLLDVKARLENEIATYRNLLESEDCKLPCNPCSTPASCTSCPSCGPVTGGSPSGHGASMGR
What are the official names of this protein?
Keratin, type I cuticular Ha7, Hair keratin, type I Ha7, Keratin-37, K37.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: THIM2_STRPN
Sequence: MQEFTNPFPIGSSSLIHCITNEISCEMLANGILALGCKPVMADDSREVLDFTKQSQALFINLGHLSAEKEKAIRMAASYANQSSLPMVVDAVGVTTSSIRKSLVKDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYPGMSFLVTGPKDLVVSKNQVAVLGNGCTELDWITGTGDLVGALTAVFLSQGKTGFEASCLAVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSLLRRDENWLDTIKGEVYE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 2, 4-methyl-5-beta-hydroxyethylthiazole kinase 2, TH kinase 2, Thz kinase 2.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: MURI_CLOK1
Sequence: MDSEDRPIGFFDSGVGGISVLKEAVKILSNENFVYFGDSKMAPYGVRTVEEVKKLTFNAVEFLLKKNIKALVVACNTATSAAIIDLRKAYSKYMPIVGIEPALKPAVECNRKGNIIIMATPMTLAESKFNNLMKRYSNSNILPLPCSGLVELIEEGKTEGEEIERYLEEKLIPLKGNGIAAVVLGCTHYPFIKKSISKVLNQDVLILDGSKGTVRQLKRQLIKYHIESNKSKIGKIKIFNSMNSQYIIKLSYKLLKE
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: DVLP1_HUMAN
Sequence: MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLVEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRSPSFQPDVASSRDGMDNETGTESMVSHRRDRARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDDSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSMTDSTMSLNIITVTLNMERHHFLGICIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRPDPVRPIDPAAWLSHTAALTGALPRPQLEEAPLTVESDMNTVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRNTLRPPACEKERRAAGSGDSDSESDHTAPSGVGSSWRERPADQLSRGSSPRSQASSYAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
What is the function of this protein?
May play a role in the signal transduction pathway mediated by multiple Wnt genes.
What are the official names of this protein?
Putative segment polarity protein dishevelled homolog DVL1P1, DSH homolog 1-like, Segment polarity protein dishevelled homolog DVL-1-like, Dishevelled-1-like.
What is the protein family that this protein belongs to?
Belongs to the DSH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLHD_ECOLU
Sequence: MGIMHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITQLTQDSRVDDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_MYCS2
Sequence: MARYTGPATRKSRRLGVDLVGGDQSFEKRPYPPGQHGRARIKESEYRQQLQEKQKARFSYGVMEKQFRRYYEEANRQPGKTGDNLLRILESRLDNVVYRAGLARTRRMARQLVSHGHFLVNGVKVDIPSYRVSQYDIIDVKEKSLNTLPFQIARETAGERPIPSWLQVVGERQRILVHQLPERAQIDVPLTEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RL21_STRT1
Sequence: MSTYAIIKTGGKQVKVEVGQAIYVEKINAEAGSEVTFNEVVLVGGDKTVVGTPVVEGATVVGTIEKQGKQKKVVTFKYKPKKGSHRKQGHRQPYTKVVINAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: MTD_METS3
Sequence: MVVKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVFGSGAKMNPEQVEDVVPKVDQFDPDFCIFISPNPGAPGPAKARELLSEKDIPAIIIGDAPGKGKKDEMDEQGLGYIIVMSDPMIGAKREWLDPTEMAIFNADILKVLAETGALRLVQNTIDGVIDGAAAGNIELPKLIITAEKAVEAAGFENPYAKAKAIAAYEMAGAVANLDMKGCFMTKGFENFIPLVAAAHEMAASAAALADEAREIEKGNDSVLRTPHMKEGNTGCKTDLISKPE
What is the function of this protein?
Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
What are the official names of this protein?
F420-dependent methylenetetrahydromethanopterin dehydrogenase, MTD, Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MTD family.