Protein: SEA2_CAEEL
Sequence: MGREYKFTGIAAKLNPLNCRLKLEIAEDLDERVPTTSTSCSVASVAAATATINTTAPTVLTKSELQKTLQKTSSSFSSSLATTTTTSSHLNAPVESMEGHSSLASYSHHHPSSSHHHHPGQQQSSSSSSSSHLQDFQSPPSASHPYYHQQQPQHQHQQAQQYGQATGSTNGGGQQQMTSMYGGNDYDQHQLHHQNQQHQASTSTQQFHHPQRPPPPQYDQPSSSTGSSLPPLHTVRYEQLPPPPSNQRTPTQQLQYPVKVVEAGGQAYAQQVQQAQQSNRSGAAGVNSALQPKPLPPLSSITSISSSAAGSSISAPSTSQPSTTSSLITSPPSTSSSSMAPRKTPPNASSSSLIKRQSQDVQEQQRVDFEVARNVSQIMSKNGLKVMHEPLLTGSLPQLAPLAPLPPPKSGVYQCPNCNRNLANARNLQRHRQTCGSAQHAAPQLAAMLQRSPPPCASAPPVAPPTAPSTSFQHHNSTGNLTLSYSSSSSRHQSSLYSPQLEHQDLVGNPNVMLSDGYEYKDDPMLYQGPSGLSDSIWSRDDSFHSEPPSASHDQLDMDHLGFPDPLQDPLHHLDSFDSADHRKETPRECHEPDELMTLDPTPPQCGSERFYGINIDDMPLSLDCDEPLMRSESASLSSSSQGRNTPAAVFTCEACKKSVSSERSLRRHYNTCKMFQTELAASGEERPPTTKRKPATKRPSKKKEASEGPEKNSAILAALRKEPAAPQQPQQLQFQQNYQPSPQFQAPYGGGSLPSISASWLHSASTSAAAAAPERSEMFTSPIVTSAPNPYIHQLPHQQPQQQKSSPLEDLLNEQDESADDDGDSRSSSGTVSNSTTTTTTATTTSSKSTGNPLFTCEHCARQLCSMSNLKRHRATCKVAASSSSNSAASRPPSQPSTPATAPATPMLQASQAPQPLQAPPQSPMETTATVTYTKTTVPPSVANTWNTEKAQLISPKPRSQTIFSEASSSMTVGDALRAQQHQQKMDQQIQIQFQQQQQQRFQHHQQQQQAGRIPPRPPNPILNQVQNPPQQVQHNQHQNQMLNPIRQPLLQSPPPPPPKKGLIEHKNTDLVLITSEPLAERMDAKRRSSEGLVAVTSTPLPPIQLPQRSQAPAPSRQQQQQPPVAYQVQFNGRPLPPMQLPPLQNPHNQQQQHQMLHQSQMNYQQVQQVQQVQHVQQQQNLQNQHHHQQQHHQQNQQQAPGNRSRSHSNVGKMEQEAQRQGSPLDSIITSVPLSIEVHHHIMKPGPLEQGQSSVDSQSTAEPSPRKASQQAYICPECKKTYASRKNVKRHRMAVHKLTLDEILANPEQPALDPLSAVGGAGRRHTVAGLETPDSALKPAPTKRKASEAPSAGVATKKGKAMAASVDEIQVKEEEEDQKEETVGSVERQEPPKKPVADDHKSAIAPLPPANTIMPPPPPYNQASAVPLNPPRTALPPLQLPPLQPLQSESPSWASMSAPPTALIPRTPRSSEFADEEDTRAMAKIAAELKRSAEDWPVLAVIEGVAAEPTNGEDIDEDEILIKRLRQGGVLEDVGDVSDLLRDVQGGVDGEPFSEDMLLEKNLSTASSVGLPSLASPGEQFGYQQYSQHPQQHPQQHPQQHPQQQQQVWNPNYEFQGYMQQQHPPMPVSQQFQQPLLQRPASQPPPARPIVKNSRRPSTTPKPPPNLTCSGCKKILGSDYSLRRHRAGCADVQQALNPEYPRPPKRKAAREAQKINEAEILASMPDPQMVAERSAAVAEAAAAEAAVERIGALPPPSVVHEIVHQVNADRQSMKKHNKTTSPPPAQEAPPTCAPDDPMSSSSSSSTSSASPLQGGAKPSTNQARHYCQFPECGKNFSSEWNLARHTRESCKMTTRAHSYEPTSAADKIDLIFMDKSKRRVSRTFLCTVSSLISYWLGEQGDRLELDTKWEHFQLLLDVHTLKVAITADNINLIAEQSKKYQLEHVIRMADQFMMNTNYTTPPTHVQL
What is the function of this protein?
RNA-binding protein, which regulates the expression of proteins required to control developmental timing of events during the L2 to L3 larval stage switch (PubMed:21471153).  Binds to the 3'UTR of the transcript of the heterochronic protein lin-28 to post-transcriptionally negatively regulate its expression in certain tissue types in the later larval stages (PubMed:21471153).  During larval development, controls the timing of seam cell division and terminal differentiation into adult alae (PubMed:21471153).  In vitro, it can also bind to DNA through its first zinc finger (PubMed:21471153).  May bind directly or indirectly to the promoter of the sex-determining factor xol-1 to activate its transcription (PubMed:23666922).  Its activation of xol-1 transcription controls sex determination and X chromosome dosage compensation to promote male development (PubMed:23666922).  Through the negative regulation of lin-28 transcript, it also has a role in the fox-1-sex-1-mediated determination of sexual fate (PubMed:21471153).  Acts in the intestine to play a role in regulating adult lifespan (PubMed:21471153).
What are the official names of this protein?
Signal element on autosome protein 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In embryos, diffusely accumulates in the nucleus at the 20- to 30- cell stage, but nuclear localization decreases after the 200-cell stage (PubMed:23666922). Diffusely localized in the nucleus and cytoplasm during the L3 larval stage (PubMed:21471153).