PharMolix/UniProtQA huggingface dataset:
Protein: LEXA_LACH4
Sequence: MSKKNSDTKQLEILRYIYDTVDHRGFPPTVREICAAVKLSSTSTVHGHLARLERKGLLIKDATKPRALEITDEGKKELGIKPKRIPVIGVVAAGHPILAVQDIDEYFPLPPDLENDAGELFMLKIHGESMINAGILNGDNVIVKKQNTANNGEIVVAMTDENEATVKRFYKEKDHYRLQPENDTMAPIILPEVTILGKVVGLYRNNID
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: GTSFL_BOVIN
Sequence: MEPEALETCPYNPHHRIPLSRFQYHLASCRRKNPKKAKKMASCKYNACHVVPIKKLEEHEAACVNKSTMEEEDSLSPLKVSLPNAGQKGNRNASPVSPRLPNPDLWNVDSTNCHPMFVLKSFIPQKLVCESDTRESETDDHNPIPDCPRRRSSDRESEPPAEDTSLLKA
What are the official names of this protein?
Gametocyte-specific factor 1-like, Protein FAM112A.
What is the protein family that this protein belongs to?
Belongs to the UPF0224 (FAM112) family.
Protein: SOCS2_BOVIN
Sequence: MTLRCLESSGNGAEGAQSQWGTAGSAEEPSPEAARLAKALRELSHTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPPLQHLCRLTINKCTSTVWGLPLPTRLKDYLEEYKFQV
What is the function of this protein?
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.  SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway.  Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Suppressor of cytokine signaling 2, SOCS-2.
Protein: ILVC_ECOHS
Sequence: MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVINLTPDKQHSDVVRTVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNGQLRDVNEAIRSHAIEQVGKKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: MIAM_SARMU
Sequence: MTLPIHFPRCVLYGMASAVWSILFLHILVGDTMSAADALSWSGGLIHSPAHRVNVMRSHHHEMGKELEQQHGGEEQQMQRDTKPAAFSNPPHLATGRGPSFVHADGQLDVSCFPHDKNIGSRTTEVAVVQVSSVQDCMKQCQSRPTCSHFTYNKNSKKCHLKDGAPVFYTYTGDMTGPRSCEHTCTDNCWMHSGNPLGTFQYSGHAPAFCWAACKGTAGCVMYTFQGGVCKLYSKNSVERA
What is the function of this protein?
Galactose-binding lectin.  Plays a role in adhesion to the host cell.  Has a potential role in invasion of host cells.
What are the official names of this protein?
Major microneme antigen, Lectin SML1.
What is the protein family that this protein belongs to?
Belongs to the microneme antigen family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, microneme.
Protein: SYM_KLEP7
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFDISYDNYHSTHSDENRELSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIDPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTTSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFISKRFDGVLAAELADPALYKTFTDAAESIGEAWDSREFGKAIREIMALADVANRYVDEQAPWVVAKQEGRDADLQAICTMGLNMFRVLMTWLKPVLPQLAARAEAFLNSELSWDAIQQPLLAHKVNPFKALYNRIEMKQVEALVEASKEEVKATAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQPLIGRLTVMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDDGAKPGQQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASF1B_MOUSE
Sequence: MAKVSVLNVAVLENPSPFHSPFRFEISFECSEALSDDLEWKIIYVGSAESEEFDQILDSVLVGPVPAGRHMFVFQADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYPDPELRENPPPKPDFSQLQRNILASNPRVTRFHINWDNNPDSLEAIENQDPNVDFSLSLSCTPVKSLGLPSCIPGLLPENSMDCI
What is the function of this protein?
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:12842904, PubMed:17054786).  Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (By similarity).  Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5ac and H4K12ac) marks in the cytosol (By similarity).  Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (By similarity).  Required for gonad development (PubMed:26850882).
What are the official names of this protein?
Histone chaperone ASF1B, Anti-silencing function protein 1 homolog B, CCG1-interacting factor A-II, CIA-II, mCIA-II.
What is the protein family that this protein belongs to?
Belongs to the ASF1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: PAND_CARHZ
Sequence: MFLTMMKGKIHRATVTEANLNYVGSITIDEELLDASGILPNEKVQVVNINNGARLETYTIPGPRGSGIISLNGAAARLCQIGDKVIIIAYALMEEKEAKQWQPKVVFVDEYNKIVKIKEKEIHGQTE
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY1_MOOTA
Sequence: MLSWTVILTGIFMAYAVGSLAGGHFLSKILYNADVRQVGSGNAGTMNVLRNLGIAAGIMTFIWDTAKGFLVVTLGLKGGGAELGVLMALAAVAGHNWPLYWRFQGGKGLATSLGVALAVYPAAVPPGAALMGLLTFLTRNTDLATLLTFSALPIYFWWREGPGCYLAFGLGLAAIMLLRHGPLVISLFYNLKERR
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 1, Acyl-PO4 G3P acyltransferase 1, Acyl-phosphate--glycerol-3-phosphate acyltransferase 1, G3P acyltransferase 1, GPAT 1, Lysophosphatidic acid synthase 1, LPA synthase 1.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PANB1_BRADU
Sequence: MSRVSEQPVDRITIPLLQRWKQDGRRLVMTTAYDAVAAPIPDPSIDISLVGDSGGNVCLGFENTPPVSVAMMNHHLEAAVRSKPRALLVADMSFLSFHVSVEETIRNAGGFLQRGAAAARLEGGGKRIEMVRAIVDCEIPVMGHLGLVPQSVNVMGGFKVQGRKVDEALRLLDDAHRLQEASCFALVLEGTPAELTARVSDSLTIPTIGIGSGPDCSEQVLCFMTCWAKPKVIAPNSFPPIRKAFSSSMMRFRAGQRMSAVARSPARKSPIGFPKALGRQLPTGRHPPQIITSVAELRRTLAKSRSANQRAGLCRRWAISTMATWR
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase 1, Ketopantoate hydroxymethyltransferase 1, KPHMT 1.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP4RS_CAEEL
Sequence: MSELSDEEISLQALYDPSKKVIGDIEDGIFSTPELQPRIKTGIDNLQLVTKLVNQMRLFSSNEQIEDVPTNSLPYLLVPCFLGILHQNLMTEPGLKLDELRKSKIYMRNFLDRLRDLCLITTRLPWEDEDTEEQNLKEKPKLAVEEIRRLKLERHKKKQELKMAELRIQKQLEAVSIDEQNLRELYITQLLFWSERCYEELQAIDDELPLLKMMAERASHPHRHPAPPPATKTVPTLKPFIITRDAQQKQVFGLGYPGIPAMSVDEWYHQKFGHNPQNAPQSSAPAGAEAQESEEEVDDDEARAKAMRWDEYKDDHRRGWGNMHNKG
What is the function of this protein?
Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis.  Probably in association with catalytic subunit pph-4. 1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex.
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 regulatory subunit ppfr-4.
Protein: KCS1_ARATH
Sequence: MERTNSIEMDRERLTAEMAFRDSSSAVIRIRRRLPDLLTSVKLKYVKLGLHNSCNVTTILFFLIILPLTGTVLVQLTGLTFDTFSELWSNQAVQLDTATRLTCLVFLSFVLTLYVANRSKPVYLVDFSCYKPEDERKISVDSFLTMTEENGSFTDDTVQFQQRISNRAGLGDETYLPRGITSTPPKLNMSEARAEAEAVMFGALDSLFEKTGIKPAEVGILIVNCSLFNPTPSLSAMIVNHYKMREDIKSYNLGGMGCSAGLISIDLANNLLKANPNSYAVVVSTENITLNWYFGNDRSMLLCNCIFRMGGAAILLSNRRQDRKKSKYSLVNVVRTHKGSDDKNYNCVYQKEDERGTIGVSLARELMSVAGDALKTNITTLGPMVLPLSEQLMFLISLVKRKMFKLKVKPYIPDFKLAFEHFCIHAGGRAVLDEVQKNLDLKDWHMEPSRMTLHRFGNTSSSSLWYEMAYTEAKGRVKAGDRLWQIAFGSGFKCNSAVWKALRPVSTEEMTGNAWAGSIDQYPVKVVQ
What is the function of this protein?
Contributes to cuticular wax and suberin biosynthesis.  Involved in both decarbonylation and acyl-reduction wax synthesis pathways.  Elongase condensing enzyme mostly active with saturated fatty acids, especially with 16:0, 16:1, 18:0, and 20:0.  Mediates the synthesis of VLCFAs from 20 to 26 carbons in length (e. g.  C20:1, C20, C22, C24 and C26).
What are the official names of this protein?
3-ketoacyl-CoA synthase 1, KCS-1, Very long-chain fatty acid condensing enzyme 1, VLCFA condensing enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: EFP_LEGPA
Sequence: MAVYSTNEFKNGLKVMVDDAPCSILDCEFVKPGKGQAFTRIKIRNLKTGRVVERTFKSGDTLPSADVADVEMQYLYNDGEYWHFMVPDTFEQYAVTENVLADAAQWLKEQDVCVLTLWNNEPIQVTPPNFVILAITETDPGLKGDTSGGGGKPATLETGAVVRVPLFVQTGELIKVDTRKGEYVSRAKE
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_MANSM
Sequence: MKFSEQWVREWVNPAVNTEQLCDQITMLGLEVDGVEAVAGEFNGVVVGEVVECAQHPDADKLRVTKVNVGGERLLDIVCGAPNCRQGLKVACAIEGAVLPGDFKIKKTKLRGQPSEGMLCSYRELGMSEDHSGIIELPADAPVGKDFREYLILDDKEIEISLTPNRADCLSIAGVAREIGVVNQLAVTEPAINPVPVTSDEKVAINVLAPEACPRYLLRSVKNVNVNAETPVWMKEKLRRCGIRSIDPIVDITNFVLLELGQPMHAFDAAKLAQPVQVRFAADGEELVLLDGTTAKLQSNTLVIADQTGPLAMAGIFGGQASGVNAQTKDVILEAAFFAPLAITGRARQYGLHTDSSHRFERGVDFELQHKAMERATSLLVEICGGEVGEICEVVSETHLPKLNKVQLRRSKLDALLGHHIETETVTEIFHRLGLPVSYENEVWTVTSASWRFDIEIEEDLIEEIARIYGYNSIPNNAPLAHLSMREHHESDLELSRIKLALVGNDFHEAITYSFVDPKLQSILHPEQAVWILPNPISSEMSAMRVSLLTGLLGAVVYNQNRQQNRVRLFETGLRFIPDESAEFGIRQELVFAAVMTGSRLSEHWASKAEPADFFDLKGYIENLLSLTKAGPYIKFVAKEFPAFHPGQSAAIVLDGEEIGYIGQLHPMAAQKLGINGKAFACELIVDKVAERNVANAKEISKFPANKRDLALVVAENIAASDILDACREVAGSKLTQVNLFDVYQGQGVPEGHKSLAISLTIQDTEKTLEEDDINAVISVVLSELKDRFNAYLRD
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPCH_ECOLX
Sequence: MENSFKAALKAGRPQIGLWLGLSSSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGTQTLLVPMVQNADEAREAVRATRYPPAGIRGVGSALARASRWNRIPDYLQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIRESGKAPGILIANEQLAKRYLELGALFVAVGVDTTLLARAAEALAARFGAQATAVKPGVY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinate semialdehyde.  Is also able to catalyze the aldol cleavage of 4-hydroxy-2-ketopentanoate and 4-hydroxy-2-ketohexanoate.  Is not stereospecific since it can cleave both substrate enantiomers.  Also exhibits significant oxaloacetate decarboxylase activity in vitro.  In the reverse direction, is able to condense a range of aldehyde acceptors (from two to five carbons in length) with pyruvate or 2-oxobutanoate.  Unlike with BphI from Burkholderia xenovorans, the aldol addition reaction lacks stereospecificity, producing a racemic mixture.
What are the official names of this protein?
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, HHED aldolase, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase, HKHD aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family.
Protein: IF2_STRP3
Sequence: MSKKRLHEIAKEIGKSSKEVVEHAKYLGLDVKSHASSVEEADAKKIISSFSKASKPDVTASQTVKPKEVAQPSVTVVKETGSEHVEKTQVSKPKSRNFKAEREARAKEQAARKQANGSSHRSQERRGGYRQPNNHQTNEQGDKRITHRSQGDTNDKRIERKASNVSPRHDNHQLVGDRNRSFAKENHKNGRFTNQKKQGRQEPQSKSPKIDFKARAAALKAEQNAEYSRQSETRFRAQQEAKRLAELARQEAKEAALKAQAEEMSHREAALKSIEEAETKLKSSNISAKSTADNRRKKQARPEKNRELTHHSQEGQKKNKKSWNSQNQVRNQKNSNWNKNKKTKKGKNAKNTNTAPKPVTERKFHELPKEFEYTEGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGDTIELLMVDYGIEAKAKVEVDDADIERFFEDENYLNPENIVERAPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIEEAGKKITFLDTPGHAAFTSMRARGASVTDITILIVAADDGVMPQTIEAINHSKAAGVPIIVAINKIDKPGANPERVIAELAEYGIISTAWGGECEFVEISAKFNKNIDELLETVLLVAEVEELKADPTVRAIGTVIEARLDKGKGAIATLLVQQGTLHVQDPIVVGNTFGRVRAMVNDLGRRVKSAEPSTPVSITGLNETPMAGDHFAVYADEKAARAAGEERSKRALLKQRQNTQRVSLDNLFDTLKAGEIKTVNVIIKADVQGSVEALAASLVKIEVEGVRVNVVHSAVGAINESDVTLAEASNAVIIGFNVRPTPQARQQADTDDVEIRLHSIIYKVIEEVEEAMKGKLDPVYQEKILGEAIIRETFKVSKVGTIGGFMVINGKVTRDSSVRVIRDSVVIFDGKLASLKHYKDDVKEVGNAQEGGLMIENFNDLKVDDTIEAYIMEEIVRK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNAS6_PAPHA
Sequence: MVLCFPLLLLLLVLWGPVCLLHAWPKHLTRAHWFEIQHIQPSPLQCNRAMSGINNYTQHCKHQNTFLHDSFQNVAAVCDLLSIICKNRQHNCHQSSKPVNMTDCRLTSGKYPQCRYSTAAQYKFFIVACDPPQKSDPPYKLVPVHLDSIL
What is the function of this protein?
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine.  Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P. aeruginosa, A. baumanii, M. luteus, S. aureus, E. faecalis, E. faecium, S. saprophyticus and E. coli.  Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria.  Probably contributes to urinary tract sterility.  Bactericidal activity is independent of RNase activity.
What are the official names of this protein?
Ribonuclease K6, RNase K6.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted. Lysosome. Cytoplasmic granule.
Protein: RL18_CLOBA
Sequence: MFKKVDKKASRTKRHLRVRKKVFGTPDRPRLSVFRSEKNIYAQIIDDVNAVTIVAASSLDKEFSTNGGNKEGAKLVGAAVAKKAIEKGITEVVFDRGGYVYHGRVQELAEGAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: QUEC_EDWI9
Sequence: MKRAVVVFSGGQDSTTCLIQALHHYDDVHCITFDYGQRHRAEIDVARRLAGQLGASAHKVLDVGLLNELAISSLTRDNIPVPTQSEDGIPNTFVPGRNVLFLTLAAIYAYQVEAEAVITGVCETDFSGYPDCRDQFVQALNHAVCLGMARDIRFETPLMWLNKAETWALADYYGQLARVRHDTLTCYNGVQGDGCGHCAACHLRAHGLQQYLANPAAVMAALKRKSGLQ
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: PTGDS_PIG
Sequence: MATPSSLWLGLALLGTLGVLQTPAQASLQPNFQEDKFLGRWFTSGLASNSSWFLEKKKVLSMCKSLVAPAPDGGFNLTSTFLRKDQCVTRTLMLRPAGPPGCYSYTSPHGGSNLEVSVVETDYKNYALLHTESGPSPGPAFRMATLYSRSQAPGAAVREKFTAFAKARGFTEDGIVFLPRNEKCLEEHE
What is the function of this protein?
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation.  Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes.  Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter.  Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier.  It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity).  Involved in PLA2G3-dependent maturation of mast cells.  PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
What are the official names of this protein?
Prostaglandin-H2 D-isomerase, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS, PGDS2.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
Protein: PYRG_CLOPS
Sequence: MSKNTKYVFVTGGVVSSLGKGITAASLGRLLKNRGLSVSIQKFDPYLNIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDENLTQNSNVTSGRVYWSVISKERKGEYLGGTVQVIPHITNAIKDRVHRVGKERDVDVVITEIGGTIGDIESLPFLEAIRQIKYDVGKENVCFIHVTLVPYLGKAGELKTKPTQHSVKELRSIGIQPDIIVCRSEKELSEDIKKKIGLFCNIDASEVIQNLDAEHLYAVPLMLHKEGLDRLVCEKLGLGCRDIDNAEWIDMVHRITHLTHTTKIALVGKYVELHDAYISVVEALNHGGLSNDTNVEIEWINAEDVTKENVDELLSGVDGVLVPGGFGDRGVEGKIEAIRWARENKKPFLGICLGMQCAVIEYARNVLGLEGAHSSELNPETPFPVIDLMPEQKDVEDLGGTMRLGLYPCKLEDNTFCKDVYASDLIYERHRHRYEFNNEYRTQLIESGLTIAGTSPDGRLVECVEVKDHPWFVAVQYHPELKSRPNRPHPLFVGFVGAALNNK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: PLSX_LACLA
Sequence: MKIAIDAMGGDFAPENIVKGVNLAKKELSDVTFQLYGDGAKIRQFLDDETNIEIVETTEIIDFHDDPVAAIKSKKDSSLVRAVTAVKKGEADAVLSAGSTGALLTAGLLLVKRIKQVSRPALMSTLPTADGRGFDMLDLGANTENTAHHLVDFAILGSYYAENVRGINKPRVALISNGAEESKGSPTVKEAHEILSAMSEINFIGNIESRDLLSGGADVVVTDGFTGNAILKAIEGTATVLMKEIKSAIMAGSVTTKIGGALIKKPLSVLKDLMSTDGAGGAAFVGLKAPVVKAHGNSSELAIASALKQIHKMLESDVSGKLVEHFEKMDK
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: SHCBP_MOUSE
Sequence: MADDLRAGGVLEPIAMVPPRPDLAAEKEPASWKEGLFLDADPCSDQGYHANPGATVKTLIPEGKTPFPRIIQTNELLFYERFRAYQDYILADCKASEVKEFTVSFLEKVLEPSGWWAVWHTNVFEVLVEVTNVDFPSLKAVVRLAEPCIYESKLSTFTLANVKELLDLKEFHLPLQELWVVSDDSHEFHQMALAIEHVRFFYKHIWRSWDEEEEDEYDYFVRCVEPRLRLYYDILEDRVPSGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLNLYSEIEQLKQKLKLIENPLLRYVFGYQKNSNIQGKGTRQNGQKVIHVVSSTMKTGLLRSLFKDRFCEESCKEETEIKFHSDLLSGINACYDGDTVIICPGHYVVHGTCSIADSIELEGYGLPDDIVIEKRGKGDTFVDCTGMDVKISGIKFIQHDSVEGILIIHHGKTTLENCVLQCETTGVTVRTSAELFMKNSDVYGAKGAGIEIYPGSKCTLTDNGIHHCKEGILIKDFLDEHYDIPKISMINNVIHNNEGYGVVLVKPTIFCDLQENTQDEINDNMVQKNKEADVTEGLDLEEMLQCVASKMEPYATADFNEQAKGNCEIINELLAISMQKGRMKKRLSELGITQADDNIMSQEMFIEIMGNQFKWNGKGSFGTFLY
What is the function of this protein?
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation.  May be a component of a novel signaling pathway downstream of Shc.  Acts as a positive regulator of FGF signaling in neural progenitor cells.
What are the official names of this protein?
SHC SH2 domain-binding protein 1, Protein expressed in activated lymphocytes, mPAL, SHC-binding protein.
What are the subcellular locations of this protein?
Midbody. Cytoplasm, cytoskeleton, spindle. Note=Displays weak localization to the spindle midzone in some early telophase cells and is concentrated at the midbody in late cytokinesis.