Protein: CRIC_ASPCR
Sequence: MGSIESDSVLSFFSQQCFQHPDNTAIDDGPNGNLSYSQLDQQSSTLAHCLRQNGIKAGQVVPLLTTSRLEMVIAVLGILKAGGVYVPVDIDQWPADRINYVLGRTCSGLVVYTGDHIPSGINLEEKCRVVQVQIRLENELKAQYEPNPRPRLMCIIFTSGTTDKPKGVMVPHTSVARFVTSPGFNYDIVPGDRVLLVLSVAFDACMGTLFNTICNGGTVILANRLNFQERSRQCTVLVMTPSILDVLSPPQSPSDYPQLERIFLGGETPSQQLLEAWSAFNDVALWIAYGPTEATCAVLCGRLQASSETGQFHPTRLGHSIPGSSVLLLTERMETIQDSNMEGEICIEGPCLTDGYWQDEERTKDRFIEYHGRRVYRTGDLGRFVTTEDNETAIEFCGRRDRVTKIRGFLVNLELDVDAGLRRLDPNITAVFSILLDRKLCTAVVPSSVDCRNLQAAWRLVAPPYLVPDKMVALDGLPLTANGKFDPRQVISILRDALQKDATMQNGTSHNNGAANDRKQYNWRSGPLTIDQTIIKGLQQVLGISQSEINMKDSAVFQGVHSLAAARLSTFCRHHGYNVSVESILTEPSLHALVEKNRHETENRPDSSAFATRTPEESSMPTQGPVTPLQKRMVLDSIVEDPRANCLQHISWYKTEDIGRLREAWKTVVTHEPIFQTTFELDETQEPSQRLIGAGLFIWEETTVTTHAAIKESLKSLPAATGLGSRFRVLHCVGSEFPHNESMFVWAVHHALIDGYSASLVFEKVDKALQNEPFESSHPFMLAAQDIAQMRDKLAPEVDHFWKDQEAQYPGAAGEPLIPEALTNQSGVDFAEHVVNVSIDNQRLRFAAQQAQATPAAIFYAAWALLLSSYTNSDTVIFGAVFSGRNLPFSWAPCMVGPLLNILPLRCRIKRDIESASFVREIHQTIQNISRFQVADRPKDTPPFASTLTVQDSGLRSGTTAIPSLHSPEVRESNLLPLTVVVETDSQITFLYRTDRFSESHVKDMAAIYMSLLDAFLDPGRSLQHCMDRRFPIEMNQAILQTGNIDSEVARVPSVDGGHTLSSLFGTVASLHPTHIAVQKGSHSITYATLVQYAARVAAVIEKKTQPGEVVAILADRSINWIVGIMGATAANTVYCPLDSSYPAEYREDLLRRSHAKLFLVPSKSQLPTADSGVATVSIEDILASDIKPLYPWRKQTPSDGAYICFTSGSTGVPKGVLCLHQGVVSLQSSSEEGRLHSEPGRRIAQFMSTGFDVCVHEVFASLCYGATLVLRKDDDDPFSHLADVDVVSMNATVAGSLDPSEYPDLHYVYLAGEPIPQRTADKWAVGRKLYNAYGPTEATIIVTRTLLQAGILVAIGKPFPSVRAYILNDRRELQPPNTLGNLFVAGVQVSHGYLDLPEATANSYFPDPFLPGSSNERMYDTGDIGFWDTDGKIQCCGRKDRQVKVRGFRINLDGISNMATLRMPTIRHAAAFVKDGAVVLCVEPEDVNTDELRARLKDALPPHAIPRTIYSIAHIPLSLNGKIDVKHLAAMEVRNDTALTNGITKANKLDSAQQTSSNGLSNGASHASSEAHLEKLIIKEWQQLLGLDPSQPLSRSDDFVLLGGDSIRQLNLAARLRSVLGLPIKVKDIIRSSTLGDLITLVAQQQEQHGKKNVPNGTPAHNSVHRPLGYKKLSPPEMEWACKYRHSQSQSTFNVPYVARLSSAVDWQRLASALETVLNRHRVLRSRFTTKDGTGERVLSEHPISVNRTVDDIDIQEVINRPFEFDSSEALIRTVISPSTLVLCISHILCDLTAINTLLYEVAATYRGLALPPVVREYFDVTWHHTVDPEKQRFWAEYLQGLSFKQPDEVKQVNGVNGCDHSNGTKIRKPRSYRGTSRTTSLSDSLYRHLIISSTKNGFTFHQFGMAVAGLVLHFLTGRDDIVLGSPFVNRPSFEDRQVIGLFLEPLPVRISVKHQNENDGGPGAREFVQSVRQSSQSALAHSVPWAELMSHLGLPFPSAQPQVFSCCVTFHDDRGTDPPLAINGVEGQYISAEGAKFPLLFEWQATRATGQHEQLTVRLEYDTDWFSAEFTEILEALLLECFRMLLEEEGSRHGEVKGRLGEVLQSEATRIGVAVDEIYETARQYLTVV
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of echinulin family alkaloid (PubMed:35843946).  The pathway begins with the biosynthesis of the cyclic dipeptide cyclo-L-Trp-L-Ala (cyclo-TA) by the NRPS criC via condensation of L-alanine and L-tryptophan (PubMed:35843946).  The prenyltransferase criA then catalyzes the first prenylation step, a reverse prenylation reaction at C2, to yield preechinulin (By similarity).  Preechinulin is the substrate of the cytochrome P450 monooxygenase criE that catalyzes the formation of the double bond between C10 and C11 to produce neoechulin A (By similarity).  The unique prenyltransferase criF functions as a competitive enzyme with criE for preechinulin metabolization and uses preechinulin for effective regiospecific prenylations.  Preechinulin is prenylated by criF at C5 or C7.  C7-prenylation leads to accumulation of tardioxopiperazine B without further modification by criF.  In contrast, the C5-prenylated tardioxopiperazine A can be prenylated again by criF, predominantly at C7 to form echinulin or less frequently at C4 to give variecolorin L.  CriF accepts also neoechilunin A to produce varlecolorin G (prenylation at C5) or isoechinulin A (prenylation at C7).  CriF further converts isoechinulin A into dehydroechinulin.  Moreover, a yet unidentified enzyme can also convert neoechilunin A into neoechilunin B by introducing a double bond between positions C14 and C17 and thus provides a further substrate to criF for C5 and C7 prenylation (By similarity).
What are the official names of this protein?
Nonribosomal peptide synthetase criC, NRPS criC, Echinulin biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.