PharMolix/UniProtQA huggingface dataset:
Protein: ATAT_PLAF7
Sequence: METFNHIDIKKYTREDLLYLRNTNNVLFKMFQKQVDEIACLSSKEQKLCGTLTSINNIINENYTIYCLIHTDGLIGFIKIGEKNLYLYDKIKLHYGKCTCVLDFYILEKFQKRGLGIKIFNFMLKDNDISAFCLCYDNPSYKLQNFLKKYFSPCVLIKQPNHFVIFSNYFKNVSIKKVYERISN
What is the function of this protein?
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules.  Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity.  Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer.  Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules.  Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
What are the official names of this protein?
Alpha-tubulin N-acetyltransferase, Alpha-TAT, TAT, Acetyltransferase mec-17 homolog.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase ATAT1 family.
Protein: ESA1_YARLI
Sequence: MALAEADLPNGKTNGKASGSEETPAPVQKVDMNVAINELRVGCKVHVEKDGEDRVAEILSVQMRRGNLEFYVHYVEFNKRLDERIAATRVDLSQGVIWPEPEKPKKPLSGAAKESSKEKKKNPSKKQKLTDSAATTPGANSEDVMDLDNLQVNGTTQDPDNFNRDEEIEKLRTGGSMTQSSHEVARVRNLQRIVLGNHVIEPWYFSPYPIELTEEDEIYICDFTLCYFGSKKQFERFRSKSTLRHPPGNEIYRDEAVSFFEIDGRKQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMTRRDEKGHHLVGYFSKEKESAEGYNVACILTLPQYQRHGYGRLLIDFSYALSKAEGKTGSPEKPLSDLGLLSYRAYWADTIIELLMEKGKQEMTIEDIASVTAMTTTDVLHTLQTYNMLKYYKGQHIICLTDSVCEKYEKMLKKRRRKVNSELLKWKPPVFTAAQLRFAW
What is the function of this protein?
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A. Z (By similarity).  Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity).  The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation.  The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity).  Recruitment to promoters depends on H3K4me.  Also acetylates non-histone proteins (By similarity).  In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
What are the official names of this protein?
Histone acetyltransferase ESA1, Protein 2-hydroxyisobutyryltransferase ESA1, Protein acetyltransferase ESA1, Protein crotonyltransferase ESA1.
What is the protein family that this protein belongs to?
Belongs to the MYST (SAS/MOZ) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Following DNA damage, localizes to sites of DNA damage, such as double stand breaks (DSBs).
Protein: RL19_AYWBP
Sequence: MSQLKGQNLIESVNQHQLKDVPFFKPGDTVKVLIKIDEGNRKRVQIFEGLVIKRQGRLVTETFTVRKIFAGVGIELTFPVHSPTNEKIEVVSRGIVRRAKLHYVRNLSSKASRIKEQR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ATPB_GOSBA
Sequence: MKINPTTSVPGVSTLEKENLGRISQIIGPVLDVAFPPGKMPNIYNALVVKGQDTAGQQINVTCEVQQLLGNNRVRAVAMSATDGLTRGMEVIDTGTALSVPVGGATLGRIFNVLGEPVDNLGPVDTRTTSPIHKSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEQNLAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGTLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYNELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFKLILSGELDGLPEQAFYLVGNIDEATAKATNLEMESKLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: PCRB_STAES
Sequence: MYDITKWKHMFKLDPAKSISDENLEALCMSNTDAIIIGGTDDVTEDNVIHLMSRVRRYPLPLVLEVSNVESVMPGFDFYFIPTVMNSKDTKYHNEILLEALKKYGHVINFDEVFFEGYVVLNANSKVAKITKAYTQLGIEDVEAYAQMAEELYRFPIMYVEYSGTYGDVDKVKAIANMLQHTQLFYGGGITNIDKANEMSNIADTIVVGDIIYNDIKKALKTVKIKESNK
What is the function of this protein?
Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP).  This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.
What are the official names of this protein?
Heptaprenylglyceryl phosphate synthase, HepGP synthase, Glycerol-1-phosphate heptaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
Protein: SECA_PSYCK
Sequence: MLSKIIGSVVGTKNERELKRMRKVVSKINAYEAAIQALSDEQLQQKTEEFKARHQGGESLDALLPEAFAICREASLRVNGMRHYDVQLIGGITLHEGKIAEMKTGEGKTLMGTLAMYLNAISGKGVHLVTVNDYLAARDAELNRPLFGFLGMTVGVIYSQQPPQEKVDAYQADITYGTNNEYGFDYLRDNMVFSLKEKKQRPLNFCIIDEIDSILIDEARTPLIISGQAEDSSRMYALINTIIPVLIRSKDEEANKNNEEEDFWIDEKNRQIEISEKGYEKIERFLIQVGELGENESLYSPSRLPLLAHVQAAIRAHHVFVKNIHYIVDDGEVVIVDENTGRTMPGRRWSEGLHQAVEAKENVEIQAENQTLATTTFQNFFRLYDKLSGMTGTADTEAAEFKSTYDLDVIVIPTHEPIARVDMDDQIFLTKLGKYKGIIREIQEIQAKGAPVLVGTATIEASEELSYLLDQEGVKHNVLNAKQHEREAEIIAQAGSPKSVTIATNMAGRGTDIILGGNWQSFIEDIDAVSPEEMARLKAQWQIKHDQVVAAGGLHIIGSERHESRRIDNQLRGRAGRQGDPGMSRFFLSLEDDLMRIFAGDRVVNMMRAMGLKEDEAIEHKMVSKSIENAQGKVESRDFDARKNLLKYDDVANDQRKVIYGQRDDLLAEMDLLEAIKIMHQEVYNAMINQFIPPGSIDDQWNVDGLEDELENEFKIAMPINDWLDEDRRLDEEGLRAKIIETALDRYHSRREQMGEKDAAQLERHFMLQSLDKHWKEHLTQMDQLRKGIHLRGYAQKNPEQEYKRESFELFQMMLGAIKSETVQDLSRVHIPTKEELEALEIQQRENAAHMQMQFEHSDIDNMDGGVERAAVQSRNVVGGATGASVAGAMAGSSDDADPYAGMNISRNAPCPCGSALKYKQCHGKI
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ILVC_ACTPJ
Sequence: MANYFNTLNLRQKLDQLGRCRFMDRNEFADGCNFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRAEAIAEKRASFTRATENGFKVGTYQELIPTADLVINLTPDKQHSKVVADVVPLMKQGSAFGYSHGFNIVEEGEQIRKDITVVMTAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWASATGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYASKLIQYGWETITEALKQGGITLMMDRLSNAAKIRAFELSEEIKVQLNDLYLKHMDDIISGEFSSTMMADWANGDVNLFKWREETGKTAFENSPKADGIKISEQEYFDNGVVMVAMVKAGVEMAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSHVATPILAEKLIPMLQKGDLGEPTPAAEIDNVYLRDINDAIRNHPVELIGQELRGYMTDMKRISSQG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ANM10_ARATH
Sequence: MRSSQNGGAMGGRAAGTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASGNPKESFKKTYFIE
What is the function of this protein?
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.  Essential for regulating flowering time.
What are the official names of this protein?
Protein arginine N-methyltransferase PRMT10.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Protein: NRPD7_ARATH
Sequence: MFIKVKLPWDVTIPAEDMDTGLMLQRAIVIRLLEAFSKEKATKDLGYLITPTILENIGEGKIKEQTGEIQFPVVFNGICFKMFKGEIVHGVVHKVHKTGVFLKSGPYEIIYLSHMKMPGYEFIPGENPFFMNQYMSRIQIGARVRFVVLDTEWREAEKDFMALASIDGDNLGPF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase IV which mediates 24-nt short-interfering RNAs (siRNA) accumulation.  Implicated in siRNA-directed heterochromatin formation through the action of DCL3 and AGO4, and subsequent DNA methylation-dependent silencing of targeted sequences.  Essential component of a self-reinforcing loop coupling de novo DNA methylation to siRNA production.  Required for intercellular but not intracellular RNA interference (RNAi) leading to systemic post-transcriptional gene silencing.  Involved in the maintenance of post-transcriptional RNA silencing.
What are the official names of this protein?
DNA-directed RNA polymerase IV subunit 7.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: METK_SHIDS
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAND5_XENTR
Sequence: MLLFRAASLLPLLCFTVGAFPFMDEEGSGSFAQEVLHSRSYPLANAHRGPFVDLPLFRQNRRKISQNFILHSDPREHMDEEALRRKLVWESAIRREKMRSHPDQVLPIGQDALKRSRCHALPFIQNVFRKNCFPVRLPNKFCFGQCNSFYVPGWPAGLSQPCTSCAPSRSRRISLPLRCRAGHLAWQEVELVEECECETRYDRNTVEPAGSGEGFLPVS
What is the function of this protein?
Plays an important role in regulating the left-right axis by blocking a tgfb1 cascade in the right posterior paraxial mesoderm.  Functions as an inhibitor of bmp, tgfb1, nodal, activin and wnt signaling in the ectoderm.  May inhibit mesodermal signals, probably through an inhibition of nodal/activin pathways.  Seems to regulates cell fate specification and competence before the onset of neural induction.  Expression in the entire ectodermal region prior to gastrulation might act to prevent fate specification in the ectoderm and ensure the maintenance of the stem-cell-like properties exhibited by ectodermal cells (By similarity).
What are the official names of this protein?
DAN domain family member 5, Cerberus-like 2 protein, Cerl-2.
What is the protein family that this protein belongs to?
Belongs to the DAN family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL4_MYCTA
Sequence: MAAQEQKTLKIDVKTPAGKVDGAIELPAELFDVPANIALMHQVVTAQRAAARQGTHSTKTRGEVSGGGRKPYRQKGTGRARQGSTRAPQFTGGGVVHGPKPRDYSQRTPKKMIAAALRGALSDRARNGRIHAITELVEGQNPSTKSARAFLASLTERKQVLVVIGRSDEAGAKSVRNLPGVHILAPDQLNTYDVLRADDVVFSVEALNAYIAANTTTSEEVSA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: COX1_DASNO
Sequence: MFITRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAMTQYQTPLFVWSVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGMLLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNLTWAKIHFIIMFVGVNLTFFPQHFLGLSGMPRRYSDYPDAYTMWNTVSSMGSFISLTAVMLMIFMIWEAFASKREVDVVELTPTNLEWLHGCPPPYHTFEEPAFVKV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LETH1_HELSC
Sequence: MQMDWLFIAVVSAIGLLSSGVPGTQGAYTTEQCRALNGTCRFYACFPKNVVIGKCDWLGWGCCARTPLERCTAKKGTCTASGCTETDTDHGPCDGGAQCCQRDPVKYCKFHGNVCGRGKCPMDHIPIGEQCMPGYPCCKRDGPAYCKSKGGKCLRRCSQIVPTDIIGVCADGVPCCKSRQSTG
What is the function of this protein?
Lethal toxin which possesses an inhibitory effect on direct electrical stimulation of the isolated hemi-diaphragm of mice.  Neither hemorrhagic nor hemolytic activities are detected.  Phospholipase A2 activity, proteolytic activity and arginine esterolytic activity are absent (By similarity).
What are the official names of this protein?
Helofensin-1, Lethal toxin 1.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family. Helofensin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LEUC_XYLFA
Sequence: MAGKTLYSKLWDIHEVARRDDGSSLIYIDRHILHEVTSPQAFEGLRLAGRPLWRVNANIATPDHNVPTTKAERQGSLLSIADTVSRLQVQTLDENCDDFGIFEFKMNDVRQGIVHVIGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVTQKMKNMQVRVEGTLPWGVTAKDIVLALIGKIGTAGGNGYAVEFSGSTIRALSMEGRMTICNMAIEAGARVGMVAVDEKTIQYVHGRPFAPKGSDWDAAVAFWRGLVSDPDAHFDRVVELSAEEIKPQVTWGTSPEMVSAVDQSVPDPERETDPVKKESLIRALKYMGLQPNDPITSIKLDRVFIGSCTNSRIEDLRAAAEVVKGRKVASTVKQAMVVPGSGLVKAQAEVEGLDKIFIEAGFEWREPGCSMCLAMNPDKLGSGEHCASTSNRNFEGRQGIGGRTHLVSPAMAAAAAVAGHFVDVREMMR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RS22_KLUMA
Sequence: MTRTSVLADALNAINNAEKTGKRQVLIRPSSKVIIKFLQVMQKHGYIGEFEYIDDHRSGKIVVQLNGRLNKCGVISPRFNVKISDVEKWTANLLPARQFGYVILTTSAGIMDHEEAHRKHVSGKILGFVY
What are the official names of this protein?
40S ribosomal protein S22, Ribosomal protein S15a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NSP1_ROTF6
Sequence: MATFKDACFHYRKITKLNRELLRIGANSVWIPVSSNKIKGWCIECCQLTELTFCHGCSLAHVCQWCIQNKRCFLDNEPHLLKLRSFESPITKEKLQCIIDLYNLLFPINPGIINRFKKIVNQRKCRNEFEQSWYNQLLFPITLNAAVFKFHSREVYVFGLYEGSSSCIDLPYRIVNCIDLYDRLLLDQINFERMSSLPASLQSVYANKYFKLSRLPSMKLKQIYYSDFSKQNLINKCKIKSRIVLRNLTEFTWDSQVSLHNDVINNKEKILTALSTSSLKRFETHDLNLGRVKADIFELGHHCKPNYISSNHWQPASKVSQCRWCNVKYVFRNMDWKMESMYNELLSFIQACYKSNVNVGNCSSIESAYPLVKDMLWHSITKYIDQTIEKLFNVMNPVKVDGQQVISFHWQIDVALYIHIKMILKTETLPFAFTLNQFRSIIKGIVNQWYDVTELDYLPLCTEQTDKLVKLEEEGKISEEHELLISDSEDDD
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7.  Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.
What are the official names of this protein?
Non-structural protein 1, NSP1, NCVP2, Non-structural RNA-binding protein 53, NS53.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP1 family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton.
Protein: PPIA_PANTR
Sequence: MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
What is the function of this protein?
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).  Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity).  Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity).  Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity).  In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity).  Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity).  Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity).  Plays an important role in platelet activation and aggregation (By similarity).  Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity).  Binds heparan sulfate glycosaminoglycans (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Nucleus. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
Protein: GLO2_TRIV2
Sequence: MQVIRLAALSDNYIFLLHDSQKNIAAVVDPAEAEPVLKQLAQLNAELVAIFNTHHHNDHVGGNQQLIQNFPQLKVYGGAEDKGRIPGQQVFLQPGDRVQFTDRVAEVIFVPGHTRAHIAYYFPPQTADTPGELFCGDTLFAGGCGRLFEGTPAQMVESLTKLRSLPENTRVWCAHEYTLKNLQFALSVDSENTELQKRFDEVKTKRSQGIATVPSLLGVEKLTNPFLRWEQPSLQSAVNSNDPVQTFARIRGLKDKF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: NUOK_PARDP
Sequence: MIGLTHYLVVGAILFVTGIFGIFVNRKNVIVILMSIELMLLAVNINFVAFSTHLGDLAGQVFTMFVLTVAAAEAAIGLAILVVFFRNRGTIAVEDVNVMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NADH dehydrogenase I, subunit 11, NADH-quinone oxidoreductase subunit 11, NQO11, NDH-1 subunit K, NDH-1, subunit 11.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: APAH_PSEPG
Sequence: MATYAVGDLQGCLQPLKCLLERVSFNPAVDRLWLVGDLVNRGPESLETLRFLYSIRQSLVCVLGNHDLHLLAAWHNVERLKKSDTLREIIEAPDADPLFDWLRQQKLLHYDEARGIAMAHAGIPPQWTLGQALGYAAEVEEALRDDSRLKLYLDGMYGNEPNKWSKNLTGVERLRVITNYLTRMRFCTAEGKLDLKSKEGLGTAPKGYKPWFAHKGRRSRHVTIIFGHWAALEGRVDEPGIIALDTGCVWGGAMTLYNVDSGEYHRCDCADDGTLRQPAQPTTLNDHT
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: Y395_NITEU
Sequence: MSWYSFGNDRSLLILKLYVQPGARQTEAVGICGEELKIKLAALPVDGKANRALTEFLAKRFNVPRKNITLKRGEQSRHKVVEVCQSSNGPEVLFSEMRAE
What are the official names of this protein?
UPF0235 protein NE0395.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.