PharMolix/UniProtQA huggingface dataset:
Protein: SYRC_MOUSE
Sequence: MDGLVAQCSARLLQQEREIKALTAEIDRLKNCGCLEASPSLEQLREENLKLKYRLNILRRSLQEERRKPTKNMININSRLQEVFGCAIRAAYPDLENPPLIVTPSQQPKFGDYQCNSAMGISQMLKAKEQKVSPREIAENITKHLPNNKYIDKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPVLGDKEKVIVDFSSPNIAKEMHVGHLRSTIIGESMSRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQAFYKESKKRFDADEEFKKRAYQCVVLLQSKNPDIMKAWNLICDVSREEFKKIYDALDITLIERGESFYQDRMKDIVKEFEDKGFVQVDDGRKIVFVPGCSVPLTIVKSDGGYTYDTSDLAAIKQRLFEEKANKIIYVVDNGQAIHFQTIFAAAQMIGWYDPKVTLVTHVGFGVVLGEDKKKFKTRSGETVRLMDLLEEGLKRSMDKLKEKERDKVLTEEELKAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEAMLQRAARETKIILDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATTFTEFYDSCYCVEKDRQTGKVLKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM
What is the function of this protein?
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:12060739).  Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
What are the official names of this protein?
Arginine--tRNA ligase, cytoplasmic, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol.
Protein: ACPH_ECO7I
Sequence: MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRSETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFVCYAREQVMTILPDSPPRFINLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQFYPRMMAQASRKAL
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: RS3_DESOH
Sequence: MGQKVNPEGLRLGIVKTWQSRWYADKEYADFILEDFKLREFVKKKLHHAGIAKVEIERSLNRIRLRIFAARPGIVIGKKGNEIEQLKNEIRQKVVAGKDLAIDIQEVKKPETVAQLVAENVAGQLERRVAFRRAMKRGVSSAMRFGVKGIKIICSGRLGGAEMARREWYREGRVPLHTLRADVDYGFVEASTTYGRIGVKVFIFKGEVLKDERKKN
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RS12_POLSJ
Sequence: MPTINQLVRQGREVEKIKSKSPAMENSPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEIISYIGGEGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGSLDLQGVKDRKQSRSKYGAKRPKKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: UVRC_HERAR
Sequence: MSDIETPDPRAIVLDTVAKLPNLPGVYRYFDAENNLLYVGKARDLKKRVSSYFLKNLASPRTALMVEKIARLETTITRSEAEALLLENNLIKTLQPRYNILFRDDKSYPYLKITGQKFPRMAYYRGAVDKKNQYFGPFPSGWAVKESMQILQKVFLLRTCEDSVFANRTRPCLLHQIHRCSAPCVNYISQEDYALDVDNAAKFLRGRQTEVLEVLQAKMLAYAEELKFEQAALVRNQINALSRVLHQQSMDTGGDADIDIIAVIVQGGRACVNLAMVRGGRHLGDRAYFPTHVDNVLTNAEESVAAEVMKAFLAQHYIDKFIPGTLILNTEIDEPELMLALMQQCGHRINLIFQPQGPRRQWLEMAQKGAEISLARLLSEQGSQQTRTRMLVDALKIDVEDIEAFRVECFDISHTQGEATQASCVVFHHHAMQNGEYRRYNINDITPGDDYAAMRQVLMRRYEKVANGDGVMPDVVLIDGGKGQVEMARQVFVELGLDISLIVGVAKGEGRKVGLETLVFVDGRAPQELGKESGALMLIAQIRDEAHRFAITGMRAKRAKARQTSRLEEIEGIGAKRRQKLLARFGGLRGVVDASVEDLSSVEGISRQLAEDIYKQLH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA_FERNB
Sequence: MRIAMVSYEVYPFAKVGGLADVVGALPKYLERQNINVDIYMPYHKKVKQNAEKYGWAIEKITEKVDASMLRTEEKFEIYKTMLPGTKEVNVFLINNEYYFNADEVYAGPDLAEQAIFFSYSVIEAIRKLNFEYDIVHVNDWQTALIPVYLKTVFRDDPLLSKIATVLTIHNLGYQGIFEPEYLRFAGLPDYLYNIDGIEFYGKINFLKGGIIFSDIINTVSPTYAKEIQQKEYGEKLEGVLRARSSDLYGILNGIDYEEFNPLTDNKIYVNYDLNTIEKKKENKKLLQKELGLPERDVPMFGMINRLVDQKGLDIMAEIMDYVSLFDIQFVLLGTGEEKYENMFKKLGEKYPEKYSINLKFDIVLAQKIYAGCDMFLMPSRYEPCGLGQMYSLRYGTIPIVRYTGGLADTVKEYNPETKEGNGFGFEGFDPAHLLKAMARAIYFYNSKEDWNTLIKNAMTMDLSWDKSAKEYVKLYQRAKSKVQR
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: MSCS_HELPX
Sequence: MDEIKTLLVDFFPQAKHFGIILIKAVIVFCIGFYFSFFLRNKTMKLLSKKDEILANFVAQVTFILILIITTIIALSTLGVQTTSIITVLGTVGIAVALALKDYLSSIAGGIILIILHPFKKGDIIEISGLEGKVEALNFFNTSLRLHDGRLAVLPNRSVANSNIINSNNTACRRIEWVCGVGYGSDIELVHKTIKDVIDTMEKIDKNMPTFIGITDFGSSSLNFTIRVWAKIEDGIFNVRSELIERIKNALDANHIEIPFNKLDIAIKNQDSSK
What is the function of this protein?
Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins.  Contributes to normal resistance to hypoosmotic shock.  Forms an ion channel of 1. 0 nanosiemens conductance with a slight preference for anions.
What are the official names of this protein?
Small-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscS (TC 1.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HBB_TAPGE
Sequence: VHLTADEKAAVTGLWGKVNVDEVGGEALGRLLVVYPWTQRFFDSFGDLSAASAVMGNPKVKAHGKKVLNSFSDGLKNLDNLKGTYAKLSELHCDKLHVDPENFRLLGNVLVCVLARHFGKEFTPQVQAAYQKVVSGVATALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CRTZ_PARS1
Sequence: MTQFLIVVATVLVMELTAYSVHRWIMHGPLGWGWHKSHHEEHDHALEKNDLYGVVFAVLATILFTVGAYWWPVLWWIALGMTVYGLIYFILHDGLVHQRWPFRYIPRRGYFRRLYQAHRLHHAVEGRDHCVSFGFIYAPPVDKLKQDLKRSGVLRPQDERPS
What is the function of this protein?
Catalyzes the hydroxylation reaction from beta-carotene to zeaxanthin via beta-cryptoxanthin.
What are the official names of this protein?
Beta-carotene hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
Protein: HXD10_LAGLA
Sequence: MSFPNSSPAANTFLVDSLISACRSDSFYSSSASMYMPPPSADMGTYGMQTCGLLPSLAKREVNHQNMGMNVHPYIPQVDSWTDPNRSCRIEQPVTQQVPTCSFTTNIKEESNCCMYSDKRNKLISAEVPSYQRLVPESCPVENPEVPVPGYFRLSQTYATGKTQEYNNSPEGSSTVMLQLNPRAAAKPQLSAAQLQMEKKMNXXANGQEPTKVSQVESPEAKGGLPEERSCLAEVSVSSPEVQEKESKEEIKSDTPTSNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISKSVNLTDRQVKIWFQNRRMKLKKMSRENRIRELTANLTFS
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-D10.
What is the protein family that this protein belongs to?
Belongs to the Abd-B homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SAP17_ORYSJ
Sequence: MARRGTEAFPDLGAQCDREDCNQLDFLPFDCDGCGKTFCAEHRTYRDHGCARAADQGRTVVVCEACGDAIERRAGDGGGDDAAVLEAHARSRRCDPARKRKPRCPVPRCKETLTFSNTSGCKGCGQKVCLKHRFPADHACAGAGAGAASKAAGAAAAARSAGQCGRDAQKKEGGGWKLPQSVRNMKIF
What is the function of this protein?
May be involved in environmental stress response.
What are the official names of this protein?
Zinc finger AN1 domain-containing stress-associated protein 17, OsSAP17.
Protein: KI2S3_HUMAN
Sequence: MSLMVISMACVGFFWLQGAWPHEGFRRKPSLLAHPGRLVKSEETVILQCWSDVMFEHFLLHREGTFNDTLRLIGEHIDGVSKANFSIGRMRQDLAGTYRCYGSVPHSPYQFSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSWSSYDMYHLSTEGEAHERRFSAGPKVNGTFQADFPLGPATQGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHVLIGTSVVKLPFTILLFFLLHRWCSDKKNASVMDQGPAGNRTVNREDSDEQDHQEVSYA
What is the function of this protein?
Receptor on natural killer (NK) cells for HLA-C alleles.  Does not inhibit the activity of NK cells.
What are the official names of this protein?
Killer cell immunoglobulin-like receptor 2DS3, Natural killer-associated transcript 7, NKAT-7.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NDUS2_DICCI
Sequence: MLNISKIFEEVKVMKNFTLNFGPQHPAAHGVLRLIVELESENVVRVEPHIGLLHRGTEKLIEGKTYTQALPYFDRLDYVSMNVQEHAYSLAVERLYLDSLDIELEIPQRAKVIRVLFSEITRVLNHIMATTTHAMDVGALTPFLWAFEEREKLMEFYERVSGARMHAAYIRPGGVAFDLPMNISEDIYKFVIQYRKRLEEIEDMLINNRIWKQRLVDIGIVSAEEALNYGFTGPLLRGAGIVYDIRKNYPYDDYDKYDFKIIIGEENNSYTRFIIRMKEMYQSLAIIEQALNNLRPGLIKLEGVNITAPDRAFVKKDMESCINHFKFFSEGFIIPANENYTIVEAPKGEFGIYLNANDTAKPYRCRIKAPGFLHLQGLNMMSKDHLLADVVTLIGTQDIVFGEVDR
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 49 kDa subunit, NADH dehydrogenase subunit 7.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: DNAK_TREPS
Sequence: MGKIIGIDLGTTNSCVAIMEGGEPVVIQNAEGGRTTPSIIGFTSDGGRVVGQPAKNQMVTNPEHTIYSIKRFIGSRFNELTGEAKKVPYKIVPQGDDVRVEVEGKLYSTQEISAFILQKMKKTAEDYLGEAVTEAVITVPAYFNDAQRQATKDAGKIAGLDVKRIINEPTAASLAFGFNKDSKREKIIAVYDLGGGTFDISILELGDGVFEVKSTNGDTHLGGDDFDARIVQWLEQGFKSDTGIDLGNDRMALQRLREAAEKAKIALSSSASTEINLPFITADANGPKHLQRTLSRSEFEKMTDDLFERTKEPCRKALKDAGISADRIDEILLVGGSTRMPKVAHVIKDVFGKEGSKGVNPDEAVAIGAAIQGGILGGDVKDVLLLDVTPLSLGIETMGGVFTPLISRNTTIPTRKSQVFSTAADGQTAVSIHVLQGERGMANQNRTLGNFDLVGIPPAPRGVPQIEVTFDIDANGIVHVSAKDLGTGKEQHIRIESSSGLSESEIDRMVKEAEANAESDKREREKIEARNVADSLIYQTEKTLKEAGDGVNAADRARIDEAIAELKTVLSGDDVASIKAKTEILQQASYKIAEEMYKRQAAAGAAAGKKSDAPSGNEAEGGDVDYEVVKDEDSK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: YJCN_BACSU
Sequence: MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIYKRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSCGTGP
What are the official names of this protein?
Uncharacterized protein YjcN.
Protein: RL31B_STUS1
Sequence: MKPGIHPDYRPVLFHDTAADVYFLIGSTAETTRTHQHTDGNTYPYIALDVSSASHPIYTGKQRKTTTEGRIAGFNKRFAGFATKK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: HISZ_LISMF
Sequence: MNLNKNLPTGTRDKLFREAQAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADAKLYRFFDEKGRLTVLRPDMTLPIGRVVSTTGVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILSGIGVLNALEIPNFQIELGHAAIYRRVIQLLNLSETAEIDFRQLIQNKSLTGIKRFVANNPSTLDDFILAIPRLFGPATAILNQAKSLTTDKGILTALREMETIVEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSSSSPAVGLALNLDSLTTLQNRAGIIKKQTPTTLLIHYDLEALPQAEKFMQETPNSELSFFETASNAISFAKKWHIPEVVHVSSQGIQTILQREVD
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUS29_CALMI
Sequence: MSSAGIPIQKKKNAYSAVKVDPNDDYATPGAFELERLFWKGSAKYTHVNEVWPGIYIGDETARDKATLQRLKITHILNSAHGKFNINTGANYYKDMLIHYYGIEAFDSPDFNLSVFFYSAAKFIRAGLNTPKLLVHCAMGRSRSATLVLAYLMIYKNMTVVDAIQEVIQRRCILPNRGFLKQLRTLDIQLAIERSNRRNGIKNNGEEKEAY
What is the function of this protein?
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate.  Involved in the modulation of AMPK and MAPK1/2 signaling pathways.
What are the official names of this protein?
Dual specificity phosphatase 29, Dual specificity phosphatase DUPD1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TIPIN_DROME
Sequence: MASLFGDDGVDDLFNDNIPTDPDQLPSDGEGEKLFADDEDNGVEPGSQDAQIVEPKKRAVRNPRPRLTVETLRGPRGIQTIEDYFKDIKFKGKGYEKTDLDEVLRRLQHWGHRMYPTYTFDDVLNNIERLGKKKPLQVHMARYRLGQLEQMRAHEAEALEEAQDEQQEGAGDEPFDEFDALLGEQIAMSRLAPPSPQQWKMSTASSNSTLATPSFSRGNAVMSTPYSGVNATFDRSGASVAPAFDRNGAPLASMDISDYGQPLPPSQPPTPAAKKLSNEQMARIAENRRLAQERLKAKQQQESGSKS
What is the function of this protein?
Required for normal progression of S-phase.  Important for cell survival after DNA damage or replication stress (By similarity).
What are the official names of this protein?
Protein TIPIN homolog, CSM3 homolog.
What is the protein family that this protein belongs to?
Belongs to the CSM3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ISPF_ACTPJ
Sequence: MIRIGHGFDVHAFGQDRPLMICGVEVPYHTGFIAHSDGDVALHALTDALLGAVALGDIGKLFPDTDMQYKNADSRKLLIEAYRQVRAQGYKVANVDVTIIAQAPKMRPYIDQMRQTIADDLQCDAMQVNVKATTTEKLGFTGRGEGIACEAVALLIKQ
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RK22_COFAR
Sequence: MLKKKKTEVYALGQHISMSADKARRVIDQIRGRSYEETLIILELMPYRACYPIFKLVYSAAANASYNMSSNDANLLISKAEVNEGTTIKKFKPRARGRSYPIKRPTCHITIVMKDISLDDEYVKINSLKKPRWKNKHTAMVYHDMYSSGGVWDKK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SECA_CLOPE
Sequence: MGLFDKIFGSYSDREVKRITPIVDKIDSLGPEMEKLSDEELKQKTFEFKDRYAKGESLDDMLPEAFAVCREASTRVLGMKHYREQLIGGIVLHQGRIAEMKTGEGKTLVATLPVYLNAIAGKGVHVITVNDYLATRDKEWMGQLYEFLGLTTGVIVHGLTNDQRREAYNADITYGTNNEFGFDYLRDNMVIYKEERVQRPLHYCIVDEVDSILIDEARTPLIISGAGSKSTDLYKIADFFVKKLREEEDYTIDEKAHAAMLTDKGVAEAEKAFGIENYADANNMELQHHITQALKANYVMKRDKDYMVKDDEIAIVDEFTGRLMEGRRYSDGLHQAIEAKEGVKVQRESKTLATITFQNYFRMYTKLAGMTGTALTEETEFREIYGLDVVVIPTHRPVQRQDHSDLVFKTAKGKYDAIVEEIIETHKTGQPVLVGTTSIEKSEYLSSLLKKKGVPHKVLNARYHEQEAEIVSHAGELGNITIATNMAGRGTDIKLGEGVLEVGGLKIIGTERHESRRIDNQLRGRSGRQGDKGHSRFYISLEDDLMRIFGSEKLQSVVDRLGLEETEAIESKMVTKSIENAQKKVEGNNFDIRKTLLGYDDVMNKQREVIYKQRSQVLEGENLEDSVQAMIEDVITNAVQAHLGNIDEDDFEKELGDLIKYLEDIMLPHGKFTVEELKTNSNEEITRKFIECAREIYKEKEEFVGSEQMREIERVIILRVVDTKWMDHIDDMDHLKQGIGLRAYKQQDPIQAYQMEGSAMFDEMINNIKIDTVRYLFHVKVEAEKPQRERVAKETGASHGGDSQEIKKKPVKKEPKVGRNDLCPCGSGKKYKSCCGREVV
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: H3A03_CYRHA
Sequence: MKASMFLALAGLVLLFVVGYASESEEKEFPRELLSKIFALDDFKGEERGCKGFGDSCTPGKNECCPNYACSSKHKWCKVYLGK
What is the function of this protein?
Selective antagonist of neuronal tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (IC(50)=1270 nM on Nav1. 1/SCN1A, 270 nM on Nav1. 2/SCN2A, 491 nM on Nav1. 3/SCN3A and 232 nM on Nav1. 7/SCN9A).  This toxin suppress Nav1. 7 current amplitude without significantly altering the activation, inactivation, and repriming kinetics.  Short extreme depolarizations partially activate the toxin-bound channel, indicating voltage-dependent inhibition of this toxin.  This toxin increases the deactivation of the Nav1. 7 current after extreme depolarizations.  The toxin-Nav1. 7 complex is gradually dissociated upon prolonged strong depolarizations in a voltage-dependent manner, and the unbound toxin rebinds to Nav1. 7 after a long repolarization.  Moreover, analysis of chimeric channels showed that the DIIS3-S4 linker is critical for toxin binding to Nav1. 7.  These data are consistent with this toxin interacting with Nav1. 7 site 4 and trapping the domain II voltage sensor in the closed state.
What are the official names of this protein?
Hainantoxin-III, HnTx-III, Hainantoxin-3.3, Mu-theraphotoxin-Hhn2a, Mu-TRTX-Hhn2a, Peptide F7-18.76.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 15 (Hntx-3) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RPO1N_THECE
Sequence: MQSIKKVIGSIDFGILSPQEIRKMSAAEITVPDTYDEDGYPIEGGLMDKRLGVIDPGLRCETCGARAGECPGHFGHVELARPVIHVGFAKTIHRVLESTCRECGRIKLTDEEIEEYFHKFEVTGNRKKAKDRLIKEIHKKAKERMVCPHCGSPQFPIKFERPTVYWELRKDEEGNEYKHRMMPSEVRDRLEKIPDRDLPLIGLDAEKARPEWMVLTVLPVPPVTMRPSITLESGIRAEDDLTHKLVDIIRINNRLKSNIEAGAPQLIIEDLWDLLQYHVTTYINNETSGIPPAKHKSGRPLKTLSQRLKGKEGRFRGNLSGKRVNFSARTVISPDPMISINEVGVPMAIAMELTVPEKVTEFNFEKLRKMVLNGPEKYPGANYVIDPEGRRIRLMENNLETVAEKLDIGWTVERHLLDGDVVLFNRQPSLHRMSIMAHRVRVMPYRTFRLNLSVCPPYNADFDGDEMNLHVPQTEEAQAEAKILMEVQNHIISPRYGGPLIAGIQDHISGGYLLTREGAYFERTEVEQMLMFAGVDVDRLPEPDKVENGVELWSGKTIFSLLLPKDLTIWYRNKLCDEPGRCEALEKLIEEKLIPDEEEVRALAYDGFTYILNGKLLSGAIDKTAYGREDGKLLDIIVREYGVERARQFLDQVTKLAIWVITHKGFTTAIDDEDLPTEALDRIREIIREAEERVNRLIEAYRNGELEPIPGKTLEETLESKIMAALAEARDNAGKVAERYLGMSNHAVIMAKTGARGKILNITQMAAMLGQQSIRGKRLYRGYRERVLTHFKPGDLGARARGFVINSYKSGLTPQEYFFHAMGGREGLVDTAVRTAQSGYMQRRLINALQDLKVEYDGTVRDPTGIIVQFRYGEDGIDPMRSWKGKTIDVNRVVLRTLLKLRGKG
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms the clamp head domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1N, DNA-directed RNA polymerase subunit A'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_LEGPA
Sequence: MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETPLATMQSPVLKGKKLVFVSILRAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKLPEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFLCLLAAPEGISNFHGEHPDVPIFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: DSBB_CHRSD
Sequence: MIIRLAGMSVRQGCLLGLLMCALMMGVALVLQYVYGLTPCPLCIGQRIAVLLAAFVFAIGALHNPAGNLGRGLYAGLAALASVLGLAVAARHVWLQSLPPENVPSCGPGLDYMMEVLPLWDVLSRVLAGSGECAEIHGSLLGMSIPQWTLLGFAVLLLIPLGMLAGIVIRRR
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DSBD_PSEA6
Sequence: MKLIASFSIFMLMSIWSFASLGQSNSFDSLFSNEPEFLKVDQAFVFDYVQNGDQLVVTWDIADDYYLYQQQFKAVSKNASLGEPIFPTGKMKEDEFFDEPQEVYYHKVSVTYPILQSQDDSAVKIRYQGCAEAGLCYPPTTQVVYLNAVNASDDLSNTDEASVESSGSVSQQFELADLLTGDQSLIWVLLIFLALGVGLAFTPCVFPMYPILSGIVIGQGKSISTSRAFVLSFVYVQGMALTYSLLGLVVASAGVQFQAALQHPIILGALIVVFALLALVMFGAWEFQLPSSWQEKLNGVSNQQKSGSYLGVLLMGAISGLVASPCTTAPLTGILLYIAQTSDLLLGFSALYALSLGMGIPLILFGITGGKLLPKAGAWMNIIKVTFGFMMLAVALMFVERLVSHMATDILWSLLGLVTFSYFYVMNQASSVTFGKGVRALVIFIGLFASAMYGYQTIFGQTSSVAGHTEQSHPRFEVVKNLDDFEQKLAAANAQGKTVMVDLYADWCVACKEFEKYTFPDTQVVDALSNTVWMQIDLTDNTATNIAFQEHFSILGLPTILFFDLQGKEISGSRVTGFMQASAFAAHAKNIL
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TDA11_YEAST
Sequence: MNKFDEFIESNEKDLDVDTSTRNSIISMSPVRKTGRKIRSASSNGYRLEHHRTSSAGSMHSQRLMTPTRLNDQDHPLQAKPDARRVVTRHSSVSVPNAMSKRRSLIQPMVVPTTPESQNNLPSVSHSEGSYGIPLESTTVLSSEQAMASGLRRSRNGSSQSVNSMIATTIPTNGVDVSALLQSLATKELELLECKQKIEDLKKQTQHEEQNYTRRARELHELKEQVSKHLDPSLNTPVKNRAFSPVYQNIPLESRTENAGNSSLPSSVSKPKNMGHQSTNQSRSVSPQDIQERRQRDDSSDSSKQSLWSKPLALFNQFDKIIQHEIERTLNWDDSLSGTPEVQEGTPTSNSESSAQQYDNEAPGARQKSPSQGSVSRSLWSFVSDVKAGLLGIEEENDNDVITDNRCDPVYKSDRQHEQKKSTHKITNRGQAEDSGDDSSLNMRKFKTTTKFQKDNAGNNSLTDESGHRTREKKSKRSSNKLSFIGEPDNDNSSVKNSVEMTDF
What are the official names of this protein?
Topoisomerase I damage affected protein 11.
What is the protein family that this protein belongs to?
Belongs to the TDA11 family.