Protein: PFA1_THRS2
Sequence: MAARAQNNGEMDTRIAVIGMSAILPCGTTVRESWETIRAGIDCLSDLPEDRVDVTAYFDPVKTTKDKIYCKRGGFIPEYDFDAREFGLNMFQMEDSDANQTISLLKVKEALQDAGIDALSKEKKNIGCVLGIGGGQKSSHEFYSRLNYVVVDKVLRKMGMPEEDIKVAVEKYKANFPEWRLDSFPGFLGNVTAGRCTNTFNLDGMNCVVDAACASSLIAVKVAIDELLHGDCDMMVTGATCTDNSIGMYMAFSKTPVFSTDPSVRAYDEKTKGMLIGEGSAMLVLKRYADAVRDGDDIHAVIRGCASSSDGKAAGIYTPTISGQEEALRRAYNRACVDPATVTLVEGHGTGTPVGDRIELTALRNLFDKAYGEGNHEKVAVGSIKSTIGHLKAVAGLAGMIKVIMALKHKTLPGTINVDNPPALYDGTPINESSLYINTMNRPWFPPPGVPRRAGISSFGFGGANYHAVLEEAEPEHASAYRLNKRPQPVLMLANSAQELASLCRAQLAAFEAALEEDKAVKNVAYIKCVEFCEEFKFPGSVPAGSARLGFLVKDAEDATATLRAICAQFAKDVAKEAWRLPREGVSFRAKGIATEGAVAALFSGQGAQYTHMFSEVAMNWPQFRQSISAMDAAQCKVAGEDKDFERVSQVLYPRKPYEREQEQDHKKISLTAYSQPSTLACALGAFEIFKDSGFTPDFAAGHSLGEFAALYAAGCVDRDELYELVCRRARIMGGKDAPATPKGCMAAVIGPDAEKIQIRSPNVWLGNSNSPSQTVITGSVEGIQAETAILQKEGFRVVPLACESAFHSPQMENASAAFKDVISKTSFRAPKAETKLFSNVSGETYPRDARDMLTQHMTSSVKFLTQVRNMHQAGARIFVEFGPKQVLSKLVSETLKDDPSIVTVSVNPASGKDSDIQLRDAAVQLVVAGVNLQGFDKWDAPDATRMKAIKKKRTTLRLSAATYVSDKTKKVREAAMNDGRCISYIKNGAAAPAPAPVVDEEAKREAARLQKQLEDAQRQLDEAKRAADEANQKLAAAKEEAKSAAASSKTSAVDTAVVEKHRAILKSMLAELDGYGSVDASALQQQPAAAAPAPAAAAPAPAAPAPAAAVDSALLARAESVVMEVLATKTGYETDMIEADMELETELGIDSIKRVEILSEVQAQLNVEAKDVDALSRTRTVGEVVDAMKAEIAGSAAPAPAAAAPAAAAPAPAAAAAPAAPAAGVDSALLERAETVVMEVLAAKTGYETDMIEADMELETELGIDSIKRVEILSEVQAQLNVEAKDVDALSRTRTVGEVVNAMKAEISGGSAPAPAAAAPAAAAPAPAAAPAAGVDSALLAKAETVVMEVLAAKTGYETDMIEADMELETELGIDSIKRVEILSEVQAQLNVEAKDVDALSRTRTVGEVVNAMKAEISGGSAPAPAAAAPAPAAPAPAAAAPAPAAGVDSALLAKAETVVMEVLAAKTGYETDMIEADMELETELGIDSIKRVEILSEVQAQLNVEAKDVDALSRTRTVGEVVDAMKAEISGGSAPAPAAAAPAPAAPAPAAAAPAPAAGVDSALLAKAETVVMEVLAAKTGYETDMIEADMELETELGIDSIKRVEILSEVQAQLNVEAKDVDALSRTRTVGEVVDAMKAEISGGSAPAPAAAAPAPAAAAPAPAAAAPAAGVDSALLAKAETVVMEVLAAKTGYETDMIESDMELETELGIDSIKRVEILSEVQAQLNVEAKDVDALSRTRTVGEVVDAMKAEISGGSAPAAAAPAPAAAAPAPAAAAPAAGVDSALLAKAETVVMEVLAAKTGYETDMIESDMELETELGIDSIKRVEILSEVQAQLNVEAKDVDALSRTRTVGEVVDAMKAEISGGSAPAAAAPAPAAAAPAPAAAAPAAGVDSALLAKAETVVMEVLAAKTGYETDMIEADMELETELGIDSIKRVEILSEVQAQLNVEAKDVDALSRTRTVGEVVDAMKAEISGGSASASAPAPAATAAAVKIDSVHGADCDDLSLMHAKVVDIRRPDELLLERPENRPVLVVDDGSELTLALVRVLGACAVVLTFDGLQLAQRAGAAAIRHVLAKDLSAESAEKAVQEAEQRFGKLGGLISQQADRFEPASILGFTLMLAKFAKASLCTSVPGGRPAFIGVARLDGRLGFTSQDGADALTRAQRGAIFGLCKTIGLEWSDSDVFSRGVDVAQNMHPEDAAVAIVREMACADIRVREVGIGANQQRCTIRAVKLEPGAPQRQISKDDVLVVSGGARGITPLCIREITRQISGGKYILLGRSKVSSSEPTWCAGISDDKAVQKAATQELKRAFAAGEGPKPTPRAITKLVGSVLGAREVRSSVAAIEALGGKAIYSSCDVNSAADVAKAVREAEAQLGGRVSGIVHASGVLRDRLIEKKLPDEFDAVYGTKVAGLENLLNTVDRANLKHMVLFSSLAGFHGNVGQSDYAMANEALNKIGLELSNSGVSVKSICFGPWDGGMVTPQLKKQFQEMGVQIIPREGGADTVARIVLGSSPAEILVGNWRTPTKKIGTETITLHRKISAKSNAFLDDHVIQGRRVLPMTLAIGSLAETCLGLFPGYSLWAIDDAQLFKGVTVDGDVNCEIALTPSEGQAGRVNVQATLKTFSSGKLVPAYRAVVVLSSQGAPPANATMQPPSLSADPAAQSAVYDGKTLFHGPAFRGIDEVLSCSKSQLVAKCRAVPGSDAARAEFATDTDAHDPFVNDLAFQAMLVWVRRTLGQAALPNSIQRIVQHRPVPQDKPFYITLRSNQAGGHSQHKHALQFHNEQGDLFIDVQASVIATDSLAF
What is the function of this protein?
Poliketide synthase-like protein; part of the polyunsaturated fatty acid synthase composed of the 3 PKS-like subunits A, B and C (PubMed:27527703).  While the saturated fatty acids (SFAs) in Thraustochytrium are produced by the conventional fatty acid synthase (FAS) pathway, polyunsaturated fatty acids (PUFAs) including docosahexeanoic acid (DHA) and docosapentaenoic acid (DPA) are synthesized via an anaerobical PKS pathway (PubMed:27527703).  PUFA synthase assimilates fatty acyl-CoA, the product of FAS, as the starter unit to synthesize DPA, and this starter unit may be butyryl-CoA, hexanoyl-CoA, or octanoyl-CoA (By similarity).  DPA and DHA biosynthesis seem to differ by the reduction at the N-3 position by PUFA synthase, not the extension of carbon chain (By similarity).  In DHA biosynthesis, PUFA synthase extends the fatty acyl chain from the methyl toward the carboxyl end, and the double bond is formed when the carbon chain is growing, instead of afterward (By similarity).  Therefore, PUFA synthase is unable to transform DPA to DHA, suggesting that DPA is not the precursor of DHA (By similarity).  Moreover, DPA molecule is partly extended by FAS KS domain, so DPA biosynthesis is less dependent on PUFA synthase KS domain than DHA (By similarity).
What are the official names of this protein?
Polyunsaturated fatty acid synthase subunit A, PUFAs-A.