PharMolix/UniProtQA huggingface dataset:
Protein: HISX_MANSM
Sequence: MQTLIWKDLTEQEKKQALTRPAISAAGNIKDAVDAIRENVVANGDKALFELSEKFDRVKLNSLEVSEQQIEEAAQRLPEELKQAIQNAKKNIEAFHLAQVPVEADVETQSGVRCQVLTRPINRVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPPPIADAILYAANLCGVETIYQVGGAQAVVAMAFGTETVAKVDKIFGPGNAFVTEAKRQVSQAVNGAAIDMQAGPSEVLVLADENADPDFVASDLLSQAEHGADSQVILVTPSERLALETELAVERQLTTLPRSEIAQKALAHSRIFIAENLQQCVEISNEYAPEHLVVQVQNARDLLSNIDNAGSIFLGAYSPESMGDYASGTNHVLPTYGYTRTSSSLGLADFSKRMTVQELSPQGFKDLAKTVEVMAAAERLDAHKQAVSIRLAKIK
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: Y042_METJA
Sequence: MNVKCPECGAWIYVVEEDSGGDAMEVKCPKCGTSIYVVKPMGEKMKNKRDKDFLDVKILEIEETKKTSPYKDTKSEDVLKALRVKANINGEIYEFRIWQIAKKPEYRGMVYVVKSVSHYCGSVKTKNFQVDEDNDIYVKQKFGIIEGVNKSKIKLPKERMEEIAEKLGFELKEGDEGLRLYLGEKYSENPPLSQRPELIEKLIKCWIAFWEPTMI
What are the official names of this protein?
Uncharacterized protein MJ0042.
Protein: BCA1_ARATH
Sequence: MSTAPLSGFFLTSLSPSQSSLQKLSLRTSSTVACLPPASSSSSSSSSSSSRSVPTLIRNEPVFAAPAPIIAPYWSEEMGTEAYDEAIEALKKLLIEKEELKTVAAAKVEQITAALQTGTSSDKKAFDPVETIKQGFIKFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFQPGDAFVVRNIANMVPPFDKVKYGGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNNSTDFIEDWVKICLPAKSKVISELGDSAFEDQCGRCEREAVNVSLANLLTYPFVREGLVKGTLALKGGYYDFVKGAFELWGLEFGLSETSSVKDVATILHWKL
What is the function of this protein?
Reversible hydration of carbon dioxide.  Required for photosynthesis in cotyledons.  Binds salicylic acid.  Together with BCA4, involved in the CO(2) signaling pathway which controls gas-exchange between plants and the atmosphere by modulating stomatal development and movements.  Promotes water use efficiency.
What are the official names of this protein?
Beta carbonic anhydrase 1, chloroplastic, AtbCA1, AtbetaCA1, Beta carbonate dehydratase 1, Protein SALICYLIC ACID-BINDING PROTEIN 3, AtSABP3.
What is the protein family that this protein belongs to?
Belongs to the beta-class carbonic anhydrase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Cell membrane; Peripheral membrane protein.
Protein: RL22_HERA2
Sequence: MQAKAILRNFRMSPQKVRLVADLVRGKNVTEALGILQYLPHKAAPEIARVIKSAKANADHNYQMSPEDLVVKTIMVDAGPVLKRYMPRARGRGDRILKRSSHITVIVDDGEVL
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: SAM14_RAT
Sequence: MASSKLREPVDEVFDLDLAVPETTRLDSSLHKARAQLLVKGRRHRPSRSRLRDSTSSAEDGEGSDGPGGKVTDGCGSPLHRLRSPLHSGPGSPAGGSFCLEPPGLRRSLDEDEPPPSPLARYRPLHNAASHEGLAATSGSPPRSAPSSDSSPSFVRRYPRAEPHSEDDSRDASPPEPASPTIGLDKKTRRKFLDLGVTLRRASTSKSRKEKGSNRLSMGSRESVEGSGRTGGSPFLPFSWFTDSGKGSASSGSTTSPTCSPKHEGFSPKKSASQESTLSDDSTPPSSSPKIPGDPRQETKCSYPYHTLSQSSDEFLDESLPAVEHWTSQQVGQWLHSLNLEQYAAEFAARQVDGPQLLQLDGSKLKSLGLSNSHDRALVKRKLKELAAAAEKERKAQEKTARQREKLRRREHEAKKS
What are the official names of this protein?
Sterile alpha motif domain-containing protein 14, SAM domain-containing protein 14.
Protein: YBEY_MYCGI
Sequence: MSIEVSNESGIDVSESELVSVARFVIRKMDVNPAAELSMVLLDTAAMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDTPEPGPSMLGDIVLCPEFAAKQAADAGHTLGQELALLTVHGVLHLLGYDHAEPDEEKEMFALQRELLEEWVAEQVEAYHLDRQNEKDRRLLDKSRYFDTP
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_CALS8
Sequence: MSQIRAIVGTQWGDEGKGKIVDFLAKEADVVVRAQGGSNAGHTVEAFGKIFKLHLIPSGILYKDKINIIGNGVVIDPESLIEEIESLQKEGISTENLRISDRAHLVMPYHKILDEEQEKQRGEESLGTTKRGIGPAYTDKTERTNLRVCDMLDEDEFVHKLRIVYERKNRILTEVYHKTPMKFGELLEQFMKYGEILRPYITDTIKLLNDAIKEGKKILLEGAQATMLDLDYGTYPYVTSSHPTVGGFCIGAGIAPKHIQEVIGVVKSYTTRVGKGPFPTELLDRVGDSIRERGKEYGTTTGRPRRCGWLDLVVVRYAVLINGIDKIALTKLDTLSNLPKVKVCVGYRHAGKILDLFPASLKVAMECEPIYEEFDGWSEEEIKKAKEYDQLPKNAKKYIEFIEKETGAKVFLIGTGASREDIIIKEN
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POXG_PENOX
Sequence: MVSLSCLISYGECLLETVQTHPWSTIGVVVFLSSVKNAPLMWHARLIIAVFYHSVTRKNDVVTIERYGRQGLFGYIVTSSRSPLYECDINGHKSDSTYFSDLDINRIHLITRLFKGAGDLSLRPDRPNVAPEDRPKKMRVLLGGTCCSFRREIKPYAAYEIHSRVLAWDEKWLYVVSYFVKPGSARKMASLQTEVGDKCEMTDLARSMVFTSAITKFVFKDGRKTVRPADALEEMGLLSASEEVVEISEAGEDLWTRSRVEERRKTGIKIAQHFIALDELHDQFEHVSEHPFLGKFGVLGTMF
What is the function of this protein?
Thioesterase; part of the gene cluster that mediates the biosynthesis of oxaleimides, cytotoxic compounds containing an unusual disubstituted succinimide moiety (PubMed:28365998).  The first step of the pathway is provided by the HR-PKS poxF that serves in a new mode of collaborative biosynthesis with the PKS-NRPS poxE, by providing the olefin containing amino acid substrate via the synthesis of an ACP-bound dec-4-enoate (PubMed:28365998).  The cytochrome P450 monooxygenase poxM-catalyzed oxidation at the alpha-position creates the enzyme-bound 2-hydroxydec-4-enoyl-ACP thioester, which may be prone to spontaneous hydrolysis to yield 2-hydroxydec-4-enoic acid due to increased electrophilicity of the carbonyl (PubMed:28365998).  2-hydroxydec-4-enoic acid can then be further oxidized by poxM to yield the alpha-ketoacid 2-oxodec-4-enoicacid, which is reductively aminated by the aminotransferase poxL to yield (S,E)-2-aminodec-4-enoic acid (PubMed:28365998).  The Hybrid PKS-NRPS synthetase poxE then performs condensation between the octaketide product of its PKS modules and the amino group of (S,E)-2-aminodec-4-enoic acid which is activated and incorporated by the adenylation domain (PubMed:28365998).  The resulting aminoacyl product can be cyclized by the Diels-Alderase PoxQ and reductively released by the reductive (R) domain of poxE to yield an aldehyde intermediate (PubMed:28365998) (Probable).  The released aldehyde is then substrate for a Knoevenagel condensation by the hydrolyase poxO followed by an oxidation at the 5-position of the pyrrolidone ring (PubMed:28365998).  The presence of the olefin from the amino acid building block allows for migration of the substituted allyl group to occur (PubMed:28365998).  This allylic transposition reaction takes place in a conjugate addition, semipinacol-like fashion to yield a succinimide intermediate (PubMed:28365998).  Iterative two-electron oxidations of the C7 methyl of the succinimide intermediate to the carboxylic acid can be catalyzed by one of two remaining cytochrome P450 monooxygenasess poxC or poxD to yield oxaleimide A (PubMed:28365998).  Subsequent oxidation yields the maleimide scaffold oxaleimide I (PubMed:28365998).  Both oxaleimide A and oxaleimide I can undergo oxidative modifications in the decalin ring to yield the series of products oxaleimides B to H (PubMed:28365998).
What are the official names of this protein?
Thioesterase poxG, Oxaleimides biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the lcsJ thioesterase family.
Protein: VLLY_VIBVU
Sequence: MVDAINPLGTDGFEFVEYTAADNTGIEQLKHLFSSLGFAEVAKHRSKEAWLYRQGDINFVVNAQPHSQAEEFAKVHGPSVCGMAFRVQDAASALKHALTNGAEEYKTEIGPMELSIPAVYGIGGSLLYFVDRYGKQSIYDVDFRFYDDAAQRLAKSDVGLYEIDHLTHNVKRGNMDTWAGFYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQIEEFIREYNGEGIQHIALTTDDIYQTVQTLRDRGMDFMPTPDTYYDKVDSRVEGHKEDVSRLRDLRILIDGAPLKDGILLQIFTQTVIGPVFFEIIQRKGNEGFGEGNFKALFESIEEDQIRRGVLNNA
What are the official names of this protein?
Hemolysin VllY.
What is the protein family that this protein belongs to?
Belongs to the 4HPPD family.
Protein: APGM1_METTH
Sequence: MKGVIMIIDGMADRPLEKLSGRTPLEAASTPNMDRIAESGINGIMDPIKPGVRAGSDTSHLSILGYDPYRVYTGRGPFEAAGVGLDVKPGDIAFRCNFATADEDMIITDRRAGRIRSGTSSIARTINSMTIEGFEDVEIIFRESTGHRAVLVLRGPGLGDKVSDADPKVEGKPPKKIKALDGSPESRKTAEVLNRIVKESYEILRDHPVNTGRIERGEAPANIILPRGAGAVPHVEKFQERYDLKAACIAETGLIKGIGHLTGMDVIDVEGATGGIDTDLESIKNAISSAIAADYDFLLINIDGADEAGHDGDLEGKVRFIERVDSILGDLMGDDIYFILTADHSTPVSVMDHTGDPVPIAITGPEVRVDDVTSFSERAAAAGGLCRIRGSDVMDILLDLMNKKEKFGA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1, BPG-independent PGAM 1, Phosphoglyceromutase 1, aPGAM 1.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Protein: EFTS_NEOSM
Sequence: MSKINLEDLKSLSKETSAGLVHCKQALSEAHGDLTRAREILKELGHAVSVKKANRGARDGVVGALSSGKFGVILELNCETDFVARNEKFQQFAQSVLEAACAAKVKSVEECLSTPLPGGQKVRDAIVEQVAVFRENIVLSRCVTYEVSQSGLLGVYVHNKYTENLGKIGVAVAVVSEADPSFLSTVAKDIAIQVMSECPCAIDVARIPPNLLESEKHKYNLEVEGKPASVAEKIIAGKLSKFYKKVVLLEQPLFSDPERSVKQYISDKEMESSAKIDVVWYEVFVLGEAS
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_RICAE
Sequence: MNKLIPVPREFFARDTNVVSTELIGKALYFQGKTAIITETESYIGQNDPACHAARGRTKRTDIMFGPAGFSYVYLIYGMYYCLNFVTEAKGFPAATLIRGVHVISPENLYLNGPGKLCKYLGINISHNKCDLINNNEFFVGDIGLKLPYSTTARIGITKGTDKLWRYVVTDITNLISQYNVQP
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: CYSN_ERWT9
Sequence: MNNIIAQQIADQGGVEAWLHAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCDLAILLIDARKGVLDQTRRHSFISTLLGIKHLVVAINKMDLVDYSQATFEQIKQDYLDFATQLPGNLDIRFVPLSALEGENVAAPSGHMGWYSGPTLLDVLETVEVQRVVEQQPMRFPVQYVNRPNLDFRGYAGTLASGSVQVGQRVKVLPSGVESSIARIVTFDGDLQQAAAGEAITLVLKDEIDISRGDLLVDASAELTPVRAATVDVVWMAEQPLAPGQSFDVKIAGKKTRARVKGIQHQVEINSLTQHSIAELPLNAIGLVDIVFDEPMVLDSYQQNPVTGGMIFIDRLSNVTVGAGMIRQPLAEETAAGSTDFSAFELELNALVRRHFPHWNARDLLGGK
What is the function of this protein?
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 1, ATP-sulfurylase large subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Protein: RS3_ACTSZ
Sequence: MGQKVHPHGIRLGIVKPWSSTWFANTQDFADNLDGDFKVRKFLNKELMNASVSRITIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRTAVAKIAGVPAQINIAEVKKPELDAKLVADSIASQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARSEWYREGRVPLHTLRADIDYNTAEAHTTYGVIGVKVWIFKGEILGGMAAIAQQPEQQPAAPKKAPRGKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: GLPK1_STRCO
Sequence: MADFIGAVDQGTTSTRFMIFDHGGNEVAKHQLEHEQILPRSGWVEHDPVEIWERTNSVMQNALRNGGLSGTDLAAIGITNQRETTVVWDPRTGRPYYNAIVWQDTRTDAIAANLERSGRGDVIRRKAGLPPATYFSGGKIQWILENVDGVREAAEQGHAVFGNTDSWVLWNLTGGPDGGIHATDVTNASRTMLMNLETLDWDDELLGFFGIPRGMLPTINPSSHPEAFGTTRTSRPLRAAVPITGVLGDQHAATVGQVCFSPGEAKNTYGTGNFLVLNTGTELVRSQHGLLTTVAYQFGDNPPVYALEGSIAVTGSAVQWLRDQMKIIKTAAESEELARTVEDNGGMYFVPAFSGLFAPYWRSDARGAIVGLARYNDNAHLARATLEAICYQSRDVVVAMEQDSSVHLDVLRVDGGVTANDLCMQIQADILGVPVSRPVVAETTALGAAYAAGLATGFWRHTDELRTHWSESRRWEPQWSEERRAQGYAGWKMAVERTLDWVKVPES
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase 1, ATP:glycerol 3-phosphotransferase 1, Glycerokinase 1, GK 1.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: SYFA_XANC5
Sequence: MSEIQSLTERALADVAAAQTPDQLEALRVALLGKSGSITAQLKQLGTLPAEQRKAAGEAINLSRDALTAALAERKHTLETAALDARLAGERIDVTLPGRRSERGGLHPVTRTLERIVEIFARLGYELSDGPEIEDDWHNFEALNFPPHHPARAMHDTFYFGDGRLLRTHTSGVQVRYMDAHKPPLRMIAAGKVYRSDSDQTHSPMFHQVEGLLVDEHSNFADLKGTLSEFVRAFFERDFEMRFRPSYFPFVEPGAEVDIAWQQPDGSTRWLEVLGCGMVHPNVLRSVGIDPERYTGFAFGLGVERFAMLRYGVNDLRAFFENDVRFLRQFA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHBQ_ECOLI
Sequence: MTPWFLYLIRTADNKLYTGITTDVERRYQQHQSGKGAKALRGKGELTLVFSAPVGDRSLALRAEYRVKQLTKRQKERLVAEGAGFAELLSSLQTPEIKSD
What are the official names of this protein?
UPF0213 protein YhbQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: RL18_METS3
Sequence: MAQGSNYKVPFRRRREGKTDYAARMKLVDYDKSRLVVRLSNAHATVQVIDYAPEGDITLASAVSKQLANYGYLGGASNTSAVYLTGYLCAKRALAKGVDSAILDIGLKSAIKGSKVFAALKGAVDAGLDIPYGEAVLPDESRINGEHVANYAESLDDDEIAKLFSKYLERGLQPADLPKNFEETKKNIDEAEE
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: KC1A_RAT
Sequence: MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQGKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGF
What is the function of this protein?
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity).  Can phosphorylate a large number of proteins (By similarity).  Participates in Wnt signaling (PubMed:11955436).  Phosphorylates CTNNB1 at 'Ser-45' (By similarity).  May phosphorylate PER1 and PER2 (By similarity).  May play a role in segregating chromosomes during mitosis.  May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity).  Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).
What are the official names of this protein?
Casein kinase I isoform alpha, CKI-alpha, CK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton.
Protein: ALR2_AGRFC
Sequence: MDMQISRQQAAGGASGHLTIDLGALRDNYLTLAGMAPASQTAAVVKADAYGLGADVVSQTLFEAGCRNFFVAHIDEALALRLRLSAKARIFVLNGLQPGNETSCAAMAITPVLNSLEQIAQWSAHARELGKTLTAAVQIDTGMCRLGLSPEELEILSAKQQLLDGIEIAFVMSHLACADEPDHVSNAAQLAVMRKAATAFPETPVCFSNSGGIFLGNDYHNALLRPGIALYGGAPSAAGPNPMKPVVRLDVAVIQTRTVPAGSLVGYGGSFTASVPTRLATIAAGYADGLPRSLSNRGAAWYNGVRLPIAGRVSMDSIILDISALPEGTLTQGSLVQMIGPDQTLEDIAEDAGTIAYEILTGLGRRYRRSYIQPGMSPATASTSVNHK
What is the function of this protein?
Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA.
What are the official names of this protein?
Alanine racemase, catabolic.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: I4A3A_XENLA
Sequence: MAAAAVAGVAGLTSGAGRKRLLREEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFCVSVLQCLDIQVRETQALILAPTRELAGQIQKVLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVCLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGGKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
What is the function of this protein?
ATP-dependent RNA helicase.  Involved in pre-mRNA splicing as component of the spliceosome.  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity).  Involved in craniofacial development (By similarity).
What are the official names of this protein?
Eukaryotic initiation factor 4A-III-A, eIF-4A-III-A, eIF4A-III-A, ATP-dependent RNA helicase DDX48-A, ATP-dependent RNA helicase eIF4A-3-A, DEAD box protein 48-A, Eukaryotic translation initiation factor 4A isoform 3 A.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: IRGM_HUMAN
Sequence: MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEVQLLQIRENVLENLQKERVCEY
What is the function of this protein?
(Microbial infection) Following infection by hepatitis C virus (HCV), promotes HCV-triggered membrane remodeling, leading to autophagy and Golgi fragmentation, a step required for HCV replication.
What are the official names of this protein?
Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 264.7 macrophage protein 47 homolog, LRG-47.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
What are the subcellular locations of this protein?
Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, phagocytic cup. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi.
Protein: RL2_XYLFM
Sequence: MPLIKFKPTSPGRRSAARVVTPNIHKGSPHASLLESQSKTGGRNHHGRITVRHIGGGCKQRYRVIDFKRDKEAIPARVERIEYDPNRTAHIALLCYIDGERCYIIAPKGLKEGDKIISGPNVPIKLGNSLPLRNIPVGTTVHAVELKPRKGAQMARSAGSSVQLVAREGVYATLRLRSGEMRRVLAECRATIGEVGNEEHNLRKLGKAGAKRWLGVRPTVRGAAMNPVDHPHGGGEAKSGQGNPHPVTPWGVPTKGYKTRKNKRTQQFIIRGRRG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: LIPB_XANOM
Sequence: MDAVAVEPVRSSAVGLPAQLRDLGHQSYGPVWRAMQRFTDARDERTADEVWVVEHAPVFTLGQAGKPEHVLAPGDIPVLQVDRGGQVTYHGPGQLVVYPLLDLRRLKIGVRDYVCKIEQALIGMLDEWNIVAERRDGAPGVYVGGAKIAALGIRVRRGCTFHGLSLNVDMDLEPFHRINPCGYQGLQVTSVLDLGGPSGMDAVKAVLLEQLARQFGLVLQPASALPDLSLPA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMS_PYRFU
Sequence: MCGIIGYIGPRRASPILVEGLKRLEYRGYDSAGIAVLNEGRIEIRKGAGKIDELVGKLKFQEIPGNIGIGHTRWATHGVPNDINAHPHTDCTGKIVVVHNGIVENFHELKEELLKKGHVFRSDTDTELIAHLIEENLRIIKNFEDAFRMALLRLKGSYALVVLFADDPERLYIARKDSPLIIGIGNGEMFVASDIPAFLAYTNKAVFLDDGEYGIVSRYEFIVKDIVTGFPKIKDVVTISWTLEMAEKGGFDHFMLKEIYEQPRAIKDAIYGNIEAIKEVAEVVSNYDKIIMIGMGTSYHAALVGKYLFQRFTKTPVIVEEASEFRYEYEDIIDKDTLVVAITQSGETADTVAGIKLAKNKGAKVLGIVNVVGSLATRIADITLYTHAGPEIGVAATKTYTTQLMVLTLLAMELGKKIGTDVSEIENILPRLPEIIDSALGLNEKIKGIAKNILPKHDLFYIGRGINVPTALEGALKIKEIAYVHAEGLSAGELKHGPLALIEEGVPVISIAPSGKTFEKMLSNIEEAKARGGYIISLGDDIRLSEISDEWIRLPKLPEEITPIVYIVPLQLLAYHLAVLRGNNPDRPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPH_SYLGU
Sequence: FLPLLFGAISHLL
What is the function of this protein?
Antimicrobial peptide.  Active against the Gram-positive bacteria S. aureus FDA209P (MIC=44. 3 ug/ml) and B. subtilis ATCC 6633 (MIC>64 ug/ml), but not active against the Gram-negative bacterium E. coli or the fungus C. albicans.
What are the official names of this protein?
Temporin-GH, AMP-5.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted.