PharMolix/UniProtQA huggingface dataset:
Protein: TBB_LYMST
Sequence: SYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEDEGEFDEEEAEGEGQEYA
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TIM9_ZYGBA
Sequence: MDSLNPREQQEFSKLIEHKQMKDFMRLYSNLVERCFTDCVNDFTSSKLTSKEQTCISRCSEKFLKHSERVGLRFQEQNAAMGQGLGR
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim9.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: IFNG_HORSE
Sequence: MNYTSFILAFQLCAILGSSTYYCQAAFFKEIENLKEYFNASNPDVGDGGPLFLDILKNWKEDSDKKIIQSQIVSFYFKLFENLKDNQVIQKSMDTIKEDLFVKFFNSSTSKLEDFQKLIQIPVNDLKVQRKAISELIKVMNDLSPKANLRKRKRSQNPFRGRRALQ
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMH_SALPC
Sequence: MKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLANELERWKQDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_ACIAD
Sequence: MRNSAMQQLNPSEISALIKQRIGDLDTSATAKNEGTIVMVSDGIVRIHGLADAMYGEMIEFDGGLFGMALNLEQDSVGAVVLGNYLSLQEGQKARCTGRVLEVPVGPELLGRVVDALGNPIDGKGPIDAKLTDAVEKVAPGVIWRQSVDEPVQTGYKSVDTMIPVGRGQRELIIGDRQTGKTAMAIDAIIAQKHSGIKCVYVAIGQKQSTIANVVRKLEETGAMAYTTVVAAAAADPAAMQYLAPYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVSADYVEKFTNGAVTGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAVNAGISVSRVGGSAQTKIIKKLSGGIRTALAQYRELAAFAQFASDLDEATRKQLEHGQRVTELMKQKQYAPYSIADQAVSVYASNEGYMADVEVKKIVDFDAALISYFRSEYAPLMKQIDETGDYNKDIEAAIKSGIESFKATQTY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DNBI_ALHV1
Sequence: MALKHQLNHAVEDNLGSKAPIGPCGFIYIYPETHFNFKEISLLGDKYAEAGAFSLPLLHGVTVEEAFVPNVKAVYKKIDMTTVSVKLSTFYNRAIIFHNVEKFESIFSGPGLGSLCKEACDLFGYVPFTPLGEGSTDVSDICPPVWQEKDAIMAVVITEGFKERLHLGKLIYLKSQMHSVMINKTEVYRIPLYDEDLFTKKSSLRRLYLPAVSEYLYYTLYTSLAQSLRVHNAASLVEAIQEQFVHDKYKMAKLVSFKEYPLATVGACDTTLMVIDAVAAELGLSYSLSFFEAPQEKTKVQDYYSWDIFASCETDSDRLEALSKWNALQAIHIHAQLFSTNSIYYVNRVARQAPIPNSKVEPNVYNSYYLQHGLANLCEETLFEDGSPAFTGAPASSLDGSSFTLQHLAYAAAFSPNLLARMCYYLQFCQHQKSTLNPAYNITEYVGSAANSPVCSLCSGQCPCVCINTLFYRLKDRFPPVLQGSRRDPYVITGITNVFNELDFLGNFASFRDKDEDQNQTEETPRYTYWQLNQTLTEKLEAAGLVDSPVADEGAGGSGSMNLEKFVRTFSDIDSLVDAEAAKFINTMIKNNVNFKESIKGVSHVIQYNCNTYWQAPCSLMLNLYYRSILTIIQDIALPISTVYESENPAQGYKPNEWLKLHYQTLWTNFKSFFIDKGVITGTEMKVVHAEQFSDFFDVDAATNNMYSPVKVQVRLARAQVLALKNIKVKNRILFSGTSMSEHYQNAFLKTANRRDNYILAGPYVKFLNSFHRQLFPNLKISCLYLWSNFCKKKQIPCVPGVSAEALNKFFSYINNNSKQFEEVNMLDVVPDSYVTYAKQRLNNAILRACGQTQFYAVTIHSIFPKVQETCALEYPHVLGTSSVDSVEDYVNNVQNLKALTVNSSLRESAANLARSRPIVTLPVVVNKYTGIAGNAQLFQSANLGYFMGRGVDKNLLGDSLFVKKQQNSYMRKKYLFMTPLVGNLLKPSYTHQGTAFEIETVKRTIQSILEDQADEDVLNRVVCELVKSLGAGCADLTLDDIQFYLGSYGMFSENILEKLDQLRELVGPWTHEWAESVLKSGTCETDEVQFVAFEEEQVKLTSMDHSGKVVGGKKRKIATMFDDLDL
What is the function of this protein?
Plays several crucial roles in viral infection.  Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein.  May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.  Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle.  Can also catalyze the renaturation of complementary single strands.  Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments.  This process is driven by the protein which can form double-helical filaments in the absence of DNA.
What are the official names of this protein?
Major DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae major DNA-binding protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=In the absence of DNA replication, found in the nuclear framework- associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).
Protein: UNG_PSEAE
Sequence: MTDNDDRIKLEASWKEALREEFDKPYMKQLGEFLRQEKAAGKVIFPPGPLIFNALNTTPLENVKVVIIGQDPYHGPGQAHGLCFSVQPGVPTPPSLQNIYKELNRDLNIPIPNNGYLQRWAEQGVLLLNTSLTVEQAKAGSHANAGWQPFTDRVIEVVNERCERLVFLLWGSHAQSKQKLIDPQRHLILKSAHPSPLSAYRGFLGNGHFSRTNKFLEQNGKTPIDWSLPDL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYW_WIGBR
Sequence: MIKKLNIFSGMQPSGIPTLGNYIGVLRQWKILQKIYNSIYCIADLHYLTNNKENSKILFKRSLDLLAIYLACDIDPNESVIFLQSHIPEHSQLSWILNCYTYFGELTRMVQFKEKIKNKKNINLGLLSYPVLMASDILLYQTDIVPVGKDQIQHLELSRTIARRFNKLHGDVFIIPEKIISKTGSKIMSLSNPNKKMSKSNLNRNNFISLLDQPYSIIEKIKNAKTDSDNPPKINFDIIKKPGISNLLSIISELRGINIKDLEISFKNKSYKYLKNEVTGAVLEHLKILQKKYFLIRKDEKYLINILKSGSKKAKKIARGTLKKVNESIGLLNF
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_JANMA
Sequence: MAAKEVIFGDAARAKMVEGVNVLANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQLVKEVASRTSDNAGDGTTTATVLAQAIVREGMKYVAAGMNPMDLKRGIDKAVAATVEQLAAIAKPCTTTKEIAQVGSISANSDASIGERIAEAMEKVGKEGVITVEDGKSLNDELDIVEGMQFDRGYLSPYFINNPEKQTAILENPFILLCDKKISNIRDLLPVLEQVAKAGRPLLIIAEDIEGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILSGGQVVAEEVGLTLEKITLEELGQAKRIEIGKENTTLIDGNGQAVTIEARVKQIRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALLRARAAIKIKGDNPDQEAGIRIVLRAMEEPLRMIVQNAGEEASVVVAKVLEGKGNFGYNAANGTYGDMVEMGVLDPAKVTRSALQNAASIAALLLTTDCMVAEVAEDKAAGGMGDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2181_ARCFU
Sequence: MIKLSYLTSYITCPRLCYFRVHVGEKRFTELTAVREIYLSLKQGFDLDWAKKRAKALHGAFDEEAFRSAANKFIFPQIDCKSVEVDATIKSKSLGLLVSVDEIVECDGELLPLFLGLNPPENGVWFKDMVKAGAAALAGNYSKALIYYGYTGDLRPVEVTFSLKKKVIKLIERVKLIQRGFLPERKESRYCNYCSFSEDCKSRAETFASKFL
What are the official names of this protein?
Uncharacterized protein AF_2181.
Protein: GLMU_CLOBB
Sequence: MYKCALVLAAGQGKRIKSDLPKVLHKVCGKEMVNHVIDTIRKAGIQDANIIIGKGAELVKERTEEKKVTYSLQSEQLGTGHAVQCASEFLKGKKGTVAVFAGDTPLIKESTIKNLFNTHIEAKNAATILTAIVDDPTGYGRIIRSGNEVLKIVEHKDCNEEELKVNEMNSAIYCFDIKLLYESLSKLSNNNEQGEYYLTDVIEILKSAGHNIGAVVTDFEETIGVNSRAQLAQAEEILKDRINLKHMENGVTLIDPKTTYIGIDVEIGKDTIIYPNNIFEGNTIIGERCTIYQNSRIKDSIIKDEVDIQSSVILDSSIGNNTTVGPFAYIRPESKIGEKARIGDFVEIKKSIIGDGTKVSHLTYIGDAEVGKECNFGCGTVVVNYDGKKKYKTIIGNHSFIGCNTNLVSPVQVGDNTYIAAGSTITSEVQEGDLAVARAKQRNIKGWVDKKGLKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAXA_CHLTR
Sequence: MSFRSVLLTALLSLSFTTTMQAAHHHYHRYTDKLHRQNHKKDLISPKPTEQEACNTSSLSKELIPLSEQRGLLSPICDFISERPCLHGVSVRNLKQALKNSAGTQIALDWSILPQWFNPRVSHAPKLSIRDFGYSAHQTVTEATPPCWQNCFNPSAAVTIYDSSYGKGVFQISYTLVRYWRENAATAGDAMMLAGSINDYPSRQNIFSQFTFSQNFPNERVSLTIGQYSLYAIDGTLYNNDQQLGFISYALSQNPTATYSSGSLGAYLQVAPTASTSLQIGFQDAYNISGSSIKWSNLTKNRYNFHGFASWAPRCCLGSGQYSVLLYVTRQVPEQMEQTMGWSVNASQHISSKLYVFGRYSGVTGHVFPINRTYSFGMASANLFNRNPQDLFGIACAFNNVHLSASPNTKRKYETVIEGFATIGCGPYLSFAPDFQLYLYPALRPNKQSARVYSVRANLAI
What is the function of this protein?
Facilitates L-arginine uptake, as part of the AaxABC system.  The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response (By similarity).
What are the official names of this protein?
Porin AaxA, Outer membrane protein AaxA.
What is the protein family that this protein belongs to?
Belongs to the OprB family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: Y294_PASMU
Sequence: MYGIKIKNVIKLFLLKFLRNKYRYKINIQHHLISIEGKCGEFDLSQLNYVYLVKDPEIRNNRLTLYLNDFFKIGVNYHGFTQMYQTLSSKYGFDDATFFEYLCKKGPFSIQIWRKKQTQNYVILDEAYTDYTQGFEIQSPEKIFIPWGTTYESLFQQTQFKEKGITYGFIFPIRIGRLLLKDVWIKPSVRKDVPILALYTECYHESATEKSYQELTSILSEHKPLIRSYIEDHSDPKLYQSVLRLNTTEFELRYYRHIRDDFDRGYTKFSIRDTTDYLDYVINEPYESQLVITDYLVIEAQNLIKMDYTDNSIVKRRPPKIKEKFRDTQSLIWTDDLNHKIGFTSDDRAIVFDKADIESFTLANIETTRRHNRSSLSICFVDKNKEAITVFLAEHHFLIPYVDKIKTLTQKEVLVLEEYIEDV
What are the official names of this protein?
Uncharacterized protein PM0294.
Protein: RL4_METMP
Sequence: MNVKVYNLDGSEKGDIELPAVFEAEYRPDLIKRAVISSLTAKLQPKGCDAFAGYRTSAKSIGKGHGKARVRRTAQGAGAFVPQAVGGRRAHPPKVEKILFERINRKEKLKALASAIAASANPEIVSARGHKIEGVPSLPLVVNAEFESLVKTKEVLEVFKTLKLDADLERAKDGVKIRAGRGKLRGRKYIKPKSVLVVVGDACEAITASRNLAGVDVITANDLSAIHIAPGTMAGRLTLWTENAIEKINGRF
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: DKSA_CAUVC
Sequence: MQTATVLVEKSDYRPSEDEPFMNDRQLEYFKQKLLAWKEEILRESRETVSHLQKETENHADLADRASSETDRALELRTRDRQRKLISKIDQALRRVEDGSYGYCEETGEPIGLARLEARPTATMSVEAQERHERRERVHRDD
What is the function of this protein?
Transcription factor that acts by binding directly to the RNA polymerase (RNAP).  Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.
What are the official names of this protein?
RNA polymerase-binding transcription factor DksA.
What is the protein family that this protein belongs to?
Belongs to the DksA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YD34B_YEAST
Sequence: MRHHQNMHYAPQQQPVYVQQPPPRRESGGCCRTCCHFLCCLCLINLCCDVF
What are the official names of this protein?
Cysteine-rich and transmembrane domain-containing protein YDR034W-B.
What is the protein family that this protein belongs to?
Belongs to the CYSTM1 family.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Membrane; Single-pass membrane protein.
Protein: ACKA_SYNJA
Sequence: MPILVLNAGSSSLKSSLFATVESTVETTPLWQAQVDFAYQPDQALIQVRRQGGPWEPFPALSSPSGISGLASLFQSLWQGEGSPLATAAEIKAIGHRVVHGGSLYRQPTLITPEVEQAIEQLSPLAPAHNPPALEGIRLLRQLLPGIPQVAVFDTAFHQQMPAAAALYPLPYAWAEQGIRRYGFHGINHEHCARRAAEILGRPLEELQLITCHLGNGCSLAAIRGGHSVDTTMGYTPLEGLMMGSRSGSVDPGILIHQLRRGMDVEELDRILNRESGLQGVSGLSSDMRVILEAMQAGHARAELAFNLFIHRLRSQIGAMLMSLDRLDALVFSGGIGENAAPVRAAACANLGFLGIQIDPVLNAGSPRNCDISTSDAPVRVLVISAQEDWAIANACQKLLQEE
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSH3_CANGA
Sequence: MKQASISRFFKKVSAVNKEKVDQVKEVEKEAEVDEVLDLTLDSENDEEQQQETPVLEPIDGEEHPTVSKVPDLNDSRLLQKQKILNASKDITNSVDVSAFNEKLKDIMNKRKLGRIKGSLIDESDEIAEQSEADEHNIKKKRKKSDQLTPLDRQVKDLKLGNMDKVLVIRVGYKYKIFAQDAIIASTILHLQLIPGKVTIDDSNPNDSKYKQFAYCSFPDVRLKVHLERLVRSGLKVAVVEQSETATTKKFDNSKAKTSVFERKITGTYSKATYATNCEFEVNHENILGTNNSIWALDIEVSDSIYKYYLWSIQLSNGEVIYDSFEESKDNFSKVETRMKYLNPSEIVSPVVDSFPIKLKKRFLDLQLCQKNYDILAEDLNIPKKELLNNRLIELWHILYRYLKEYSNEKLLNIGSNYRHFSQKISIQLQAQTINNLDLISNDDSKGTLFWILDHTRTPFGKRLLKEWLLRPLLSKDAIVDRLNAIDCILESANSIFFESLNQMMKGIPDLLRTINRVSFGKTSQREVYFLLKQLTGVIKHFEAHKDYIEVEINSNSGAIKTKSTKLASIMTQMFEFSLSSVIPQLLLMINVSAVMEKDQKKQLLGFFHLNNYDNSENIIKMQRDIDSVKAQLHDELQNIKKILKRPHLAYKDEVDFLIEVRNTQVKGIPSDWVKVNNTKMISRFLTPRTKELVELLEYQNDLLYNEISKEYDQFLNRIASYYNEVKTFIMNLAEYDCLLSLAAVSCNVGYTRPVFTDSNEQLIIAKQARNPIIESLGVDYVPNDIEMEKDSGRVLVITGPNMGGKSSYIRQIALMVIMAQIGSYVPAESLKLSVFDNVLTRIGSQDNILQGQSTFKVELSETVEIINSCTSKTLLLLDEVGRGTSTRDGNAIAWALIKYFVEEEQCPFILFTTHFTIVTTVKSPLLKSYHMNYVQHKNENENWTTVVFLYQLKAGVTDSSYGLNVAKLAGIDTHIINRAHDVAISYKNDTEFDTNMILFQKVRNILANRTTARETLKVLLELDV
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  MSH3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MSH3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TDCC_ECODH
Sequence: MSTSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYEKDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFAITLEYAASIIALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSLGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTVIGLLTILNIVYKLF
What is the function of this protein?
Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Threonine/serine transporter TdcC, H(+)/threonine-serine symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS21_ARATH
Sequence: MAERGGEGGAERGGDRGDFGRGFGGGRGGGRGRDRGPRGRGRRGGRASEETKWVPVTKLGRLVADNKITKLEQIYLHSLPVKEYQIIDHLVGPTLKDEVMKIMPVQKQTRAGQRTRFKAFVVVGDGNGHVGLGVKCSKEVATAIRGAIILAKLSVVPVRRGYWGNKIGKPHTVPCKVTGKCGSVTVRMVPAPRGSGIVAARVPKKVLQFAGIDDVFTSSRGSTKTLGNFVKATFDCLQKTYGFLTPEFWKETRFSRSPYQEHTDFLSTKAVSATKVITEGEDQA
What are the official names of this protein?
40S ribosomal protein S2-1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: EFMT1_BOVIN
Sequence: MSDSENEGPPQLSSYALAALQEFYAEQQHHHSDLCGDDKYNIGIIEENWQLSQFWYSPETATCLAEDAVAAAGEGGRIACVSAPSVYQKLRERHRDDVSVCIFEYDRRFAIYGEDFVYYDYKNPVDLPERIATHSFDIVVADPPYLSEECLRKMSETIKLLTRGKILLCTGAVMEDAAAKLLGVKMCKFIPEHTRTLGNEFRCFVNYNSGLDCNLSVQLPVQEGPK
What is the function of this protein?
Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
What are the official names of this protein?
EEF1A lysine methyltransferase 1, N(6)-adenine-specific DNA methyltransferase 2, Protein-lysine N-methyltransferase N6AMT2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALG8_HUMAN
Sequence: MAALTIATGTGNWFSALALGVTLLKCLLIPTYHSTDFEVHRNWLAITHSLPISQWYYEATSEWTLDYPPFFAWFEYILSHVAKYFDQEMLNVHNLNYSSSRTLLFQRFSVIFMDVLFVYAVRECCKCIDGKKVGKELTEKPKFILSVLLLWNFGLLIVDHIHFQYNGFLFGLMLLSIARLFQKRHMEGAFLFAVLLHFKHIYLYVAPAYGVYLLRSYCFTANKPDGSIRWKSFSFVRVISLGLVVFLVSALSLGPFLALNQLPQVFSRLFPFKRGLCHAYWAPNFWALYNALDKVLSVIGLKLKFLDPNNIPKASMTSGLVQQFQHTVLPSVTPLATLICTLIAILPSIFCLWFKPQGPRGFLRCLTLCALSSFMFGWHVHEKAILLAILPMSLLSVGKAGDASIFLILTTTGHYSLFPLLFTAPELPIKILLMLLFTIYSISSLKTLFRKEKPLFNWMETFYLLGLGPLEVCCEFVFPFTSWKVKYPFIPLLLTSVYCAVGITYAWFKLYVSVLIDSAIGKTKKQ
What is the function of this protein?
Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide (By similarity).  Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (By similarity).
What are the official names of this protein?
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked glycosylation protein 8 homolog, Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG6/ALG8 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL3_BACC7
Sequence: MTKGILGRKIGMTQVFAENGELIPVTVIAANPNVVLQKKTTETDGYNAIQLGFEDKREKLTNKPEQGHTAKASTTPKRFIREIRDADVDGLEVGQEVKVDVFATGEIVDVTGISKGKGFQGVIKRHGQSRGPMSHGSRYHRRPGSMGPVAPNRVFKGKKLAGRMGGDQVTIQNLEIVQVDTERNLLLVKGNVPGAKKSLVVVQGAVKVSK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: LEUD_AGRVS
Sequence: MEKFTKLTGVAAPLPVVNIDTDMIIPKDYLKTIKRTGLGTGLFAEARYHQDGSINQDFVLNKPAYQNAKILVAGDNFGCGSSREHAPWALLDFGIRCVISTSFADIFYNNCFKNGILPIVVSQENLEKLMDDAQRGSNAVVTVDLETQEITGPDGGSISFEIDEFKRHCMLNGLDDIGLTMEKSSAIASFETANAASRPWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: DHS5_CAEEL
Sequence: MAPTPPPPLSSTLIPEESSTSFFASLHSLLPTFHVENGAQLAVTMLLLIPVVYVGYRLYRTFFAFLKAIFIYTIAPLFYKPNLEQYQHRWTVVSGGTDGIGKAYTLELAKRGLRKFVLIGRNPKKLDSVKSEIEEKHSDAQIKTFVFDFGSGDFSSLRDYISDIDVGFVVNSVGTGRDNLERYGDNPDEDTQILRVNGMGAAEFLSCVLPPMEKSGGGQIVVLSSSQGVRPIPMLAAYCATKALMTFLCESIDREYSTINVQTLIPALVATKMTYYTKGSTFVVTPENFCHQAVGSIGLTKKTAGCLNHELQMLGFHLFPWTILKYLIMPIYYHQRKRVTELHNTSNNPEQEISLQELNEETVVPTTKKTVTRDSATA
What are the official names of this protein?
Uncharacterized oxidoreductase dhs-5, Short-chain dehydrogenase 5.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.