PharMolix/UniProtQA huggingface dataset:
Protein: SYC_STAMF
Sequence: MYGIKIYNTLTRKIEEFKPVSPGFVKMYVCGPTVYDYNHIGHGRVYVVYDALKRYLALRGYHVLHVMNITDIDDKIINRAHQEKRDWREIAETYTRDYLESLGKLNVKVDLHPRVTEHIKEIIEFIQILIDKGYAYVAPSGSVYFEVDKYPEYGELSGRTNKELWSQEKEFISEKKKPYDFALWKAWKPGEPHWDAPWGKGRPGWHIECSVMSSRYLGRQFDIHGGGTDLIFPHHENERAQSEAAFGVKPWVKYWVHTGMVMMGSEKMSKSLGNIIPLREAFKEWGPETLRLWYLTSHYRRPLVFTEESIRQAQKYYERLVSVTNTIKKLSREAVSLHRMNDEDLKILEKLLEIRSRFHEALSNDFNTPQALAVISEFMTLVFKEIQYNPKYMLVLTAYKLLREFNTVLGVLDKYLVETPEELETLLDNVINIVVDIRRELRERKLYDLADRIRSELGKHGIILMDRGKETTWMRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDLI7_DANRE
Sequence: MNIYCVTLNGPAPWGFRLQGGKDFNTPLTVSRLTPGGKAAQAGVGVGDWVVSIFDANAEEMTHVEAQNKIRAATDSLKLTLSRAFHPAGGEQKDSLTSSSSQPKYSFAPSTAINKMARPFSASPGSGSAGPVIKPVSYALKPALSSPHNGHGVAPCPVTVKSKPADKHDAVQAPAKAPVSSGPACRPPWVTDPGFADRYHPDKSSTVVTQHTQPLQPTPMQNRSSILQAAQQSPAHSSTATPLCAACSKIIRGRYVVALGRSWHPEEFMCCQCKRLLDEGGFFEEKGSIYCSKCYDNRYSPNCAKCKKIITGEIMHALKMTYHVQCFLCAACKLPIRNQAFYMEEGEPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGYSWHDTCFVCAICQINLEGKTFYSKKDKPLCKSHAFSPL
What is the function of this protein?
May function as a scaffold on which the coordinated assembly of proteins can occur.  May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity).
What are the official names of this protein?
PDZ and LIM domain protein 7.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y2866_ENTFA
Sequence: MGRKWANIKEKKAAKDANNSRVYAKFGIEIYVAAKSGDPDPHANQKLRFVIERAKTYNVPKHIIDRAIEKAKGSADEQYSELRYEGFGPNGSMVIVDALTNNVNRTAADVRAAFGKNGGNMGVSGAVSYMFDNTGIIGFAGDDADEILEYLMEKDIDVRDVVEEDGQIIVYTEPEDFHHAQEALKEKGIEEFTVTELEMVPQNEVTLEGDDLGNFEKMLDVLEDLEDVQKVHHNVDLPE
What are the official names of this protein?
Probable transcriptional regulatory protein EF_2866.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family. YeeN subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_ANTSP
Sequence: MENNFQVFRLISENFSEVSHSIGLNSDFLEANVLNIMLLLFGLIYVLKQFLGSLLTIRQEKVIFAISECEERLQQANNRLLESEKQLEQTQLVITQVLNDAEITAQKVRQSILDKGKIDVEKLIGASKASIVVAENQINQQIKQKITALAIQKVSSQLKAQVDTTMQAKIIDSSIIKLRGDI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: GPPA_SALA4
Sequence: MNSTSLYAAIDLGSNSFHMLVVREAAGSIQTLTRIKRKVRLAAGLNNDNHLSAEAMERGWQCLRLFAERLQDIPQPQIRVVATATLRLAVNAGEFIAKAQTILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFSDRNLAQENFDDAEKAARDVLRPVADELRFHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQLKQRAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFTELNIQSMTLAGGALREGLVYGMLHLAVDQDIRSRTLRNIQRRFIVDTDQANRVAKLADNFLKQVENAWHIEPISRELLLSACQLHEIGLSVDFKQAPYHAAYLVRHLDLPGYTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAILFAGRRRDDLVPEITLQALNENLTLTLPGDWLAHHPLGKELIDQESQWQSYVHWPLDVR
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: MIAA_ACIF2
Sequence: MQSWATDGSVFFLGRSRPPLSPRAMIPAIFLMGPTASGKTELAVRLADALPIDIISVDSLLVYRHFDIGSAKPSLALRQQYPHALVDIREPDEPYSAGLFREDALHCIALARERGRIPLLVGGTGLYFRALECGIDTLPPANPALRQSLMALAETAGWPALHQRLATLDPEAAAGIAPHDRQRIQRALEIILGSGQTISGARHWQGTFPGPLYKIILRPPRSWLHQRITQRFDVMLNEGFLDEIADLSARHYAPELPAMRAVGYRQYFTWHDGLCSAAEAYQAALAATRQLAKRQDTWFKRESAHYYLDPSRDDASSLLLQMATRPRQGEVHSIGWDNG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: KTHY_BORBR
Sequence: MTPRGRFITLEGVDGAGKSTHTAWMVQALRDLGLTVLATREPGGTPVGEKLRELLLSEPMALETETLLMFAARCEHVREVIAPALARGEWVVCDRFTDASYAYQGGGRQLGAARVAALEQWVHPDLQPDRTWLFDVPLDVARARLARSRQLDRFEREEDAFFERTRAAYHERARSSDGRIRIIDSSRPLEVVRAQLDSEVRELVAQAA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: M1AP_HUMAN
Sequence: MHPGRTTGKGPSTHTQIDQQPPRLLIVHIALPSWADICTNLCEALQNFFSLACSLMGPSRMSLFSLYMVQDQHECILPFVQVKGNFARLQTCISELRMLQREGCFRSQGASLRLAVEDGLQQFKQYSRHVTTRAALTYTSLEITILTSQPGKEVVKQLEEGLKDTDLARVRRFQVVEVTKGILEHVDSASPVEDTSNDESSILGTDIDLQTIDNDIVSMEIFFKAWLHNSGTDQEQIHLLLSSQCFSNISRPRDNPMCLKCDLQERLLCPSLLAGTADGSLRMDDPKGDFITLYQMASQSSASHYKLQVIKALKSSGLCESLTYGLPFILRPTSCWQLDWDELETNQQHFHALCHSLLKREWLLLAKGEPPGPGHSQRIPASTFYVIMPSHSLTLLVKAVATRELMLPSTFPLLPEDPHDDSLKNVESMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASKMPAASKSSSDAFFLPSEWEKDPSRP
What is the function of this protein?
Required for meiosis I progression during spermatogenesis.
What are the official names of this protein?
Meiosis 1 arrest protein, Meiosis 1-arresting protein, Meiosis 1-associated protein, Spermatogenesis-associated protein 37.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIGV_BACSU
Sequence: MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESIKKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYKDTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQLTKEDLS
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Positively regulates the expression of proteins involved in stress responses against bacitracin, paraquat and tellurite.
What are the official names of this protein?
RNA polymerase sigma factor SigV.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. ECF subfamily.
Protein: Y1643_MOOTA
Sequence: MPGDMQETMMFKVEKEEKVRVRDVLTEVQAALTEKGYDPINQLIGYLLSGDPAYITSHKGARNLIRRVERDEILAELLKSYLA
What are the official names of this protein?
UPF0297 protein Moth_1643.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: SYR_PSESM
Sequence: MKDTIRQLIQQALTRLVTEGVLPEGLTPAIQVENARDKTHGDFASNIAMMLAKPAGMKPRDLAEKLIAALPADEQVSKVEIAGPGFLNFFQNTAALASRLDAALSDPQLSVRKAGAAQRVVVDLSAPNLAKEMHVGHLRSTIIGDGVANVLEFLGDTVIRQNHVGDWGTQFGMLLAYLQEKPATSDELSDLENFYRAAKQRFDESEEFAERARGLVVKLQAGDAECLTLWTRFKDISLSHCQQTYERLNVKLTPADVMGESAYNDDLANVVNDLKAAGLLVESNGAQCVFLEEFRTADDTPLPVIVQKAGGGYLYATTDLAAIRYRSKVLKADRALYFVDQRQALHFQQVFEVARRAGFVHEGMQLEHMGFGTMNGADGRPFKTRDGGTVKLIDLLDEAQERAYTLVKEKNPQVAEAELRSIAKAVGISAVKYADLSKHRASDYSFNFDQMLSFEGNTAPYLLYAYTRVAGVFRKLGTPFDASKGHIVLEAPQEQELAARLAQFNETLNNVAEKGTPHVLCAYLYDLAGLFSSFYENCPILGAENPDQQQSRLRLAALTGRTLKQGLDLLGLETLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORN_RALSO
Sequence: MSTPLSQPAAASSSATHVTTKIAAKSDNNLVWLDMEMTGLSPENDRIIEVAMVVTDSELNVLAEGPVLVIHQPDEILDGMDAWNKGTHGRSGLIDKVKASTTTEAQAEADLLDFLKKWVPKSKSPMCGNSICQDRRFMARYMPKLEAYFHYRNLDVSTLKELCKRWQPAIAKGFIKRQQHTAYADIVESIEELRYYRQHFIRDVPQTPEAEALASSVAP
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECD_VIBAL
Sequence: MLNRYPLWKYLMVFFAIITAALYALPNIYGEDPAIQVTGARGASVDMSTLDAVTTALDKEQLSHKSIALENGSILVRFNDTDTQISARDVISEALGKDTIVALNLAPSTPDWLEAIGASPLKLGLDLRGGVHFLMEVDMDAAMEKLVGQQEEAFRSELREAKIRYRAIRPSGKEAVEVLLRNEEQLAEAKAMLEKNHPDMLFVESDSNGRYALTATFTEQRLQEIRNYAVEQNITILRNRVNELGVAEPLVQRQGASRIVVELPGVQDTARAKEILGATATLEFREVDDKADLSAAANGRAPAGSEIKMDRDGRPVVLKKRVILGGQSITDASSSVDEYGRPQVNISLDSEGGNKMSAFSKKNIGKLMATVFAEYKDSGRRTPEGKVILDKHEEVINQATIQSALGRNFRITGIDSAAEAHNLALLLRAGALIAPISIVEERTIGPSMGQQNIDMGIQACIWGMVAVMLFTLLYYRGFGLIANIALMANLVLIIGVMSMIPGATMTLPGIAGIVLTVGMAVDANVLIFERIREELRDGRSPQQAIHQGYANAFSTIADANITTLITAIILFAVGTGAVKGFAVTLSIGILTSMFTAIIGTRCIVNLIYGGKRVDKLSI
What is the function of this protein?
Expression of V. alginolyticus SecDF in an E. coli secDF mutant restores protein export in a Na(+)-dependent manner, strongly suggesting SecDF functions via cation-coupled protein translocation.
What are the official names of this protein?
Protein translocase subunit SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRUB_LACAC
Sequence: MLNGIIVIDKDKGMTSADVVYHLRRALHIRKIGHAGTLDPEVTGVLPIAIGQATKLIELMHTRPKKYQGTGLFGYATDSYDIDGKVLKEKRLVMPFTVEEIQRGMNTFKGKIEQVPPIYSAVKVNGKHLYEYAREGIKVERPKRQVEIFQYDLLNDPSFDKEKGQESFDFEITCSKGTYVRSLVNDLGEKLDEPAVMTYLRRVASSGFDISQAVKLSEIEANPEKASELIQPIDAFFKDYETIDLPEGKWLKVKNGAGISLETNAKKVALRYNEKVKAIYEKKGKIYRPSLMLLQNE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: MATK_CANSA
Sequence: MTEFQGYLELDRSWQHDLLYPLIFREYIYTFVHDHGLNRNKSNLLENVGYDNKSSLLIVKRLISRMYQQNHLIISANDSNQNPVFGYNKFFFSQMISEGFAVVVEIPFSLRLVSSLKGTELVKYYNLQSIHSTFPFFEDKFPHLNYVSDVLIPYPIHLEILVQTLRYWVKDVSSLHLLRLFLHEYYSWNRFRIPKKSISFFSKSNPRFFLFLYNSYVCEYESILLFLRNQSSHLRLTSSEGFFERIYFYGKMKHPVKEVFADDFPTNLWFFQDLVIHYVRYQGKSILASKDMPLLMNKWKFYLVHLWQCHFYVWSQAGSISINQLSKHAFGFLGYLSSMRINLSVVRSQMLENSFLMDNAMKKIDTLISISPLIGSLAKMKFCNVVGQPLSKSTWADLSDFDIIDRFARICRNLFHYYSGASKKKSLYRVKYILRLSCVKTLARKHKSTVRTFLKRLGSELLDEFFTEEEEVLSLIFPRTYSTLRRLYKGRIWYLDIFCINDLVNYE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: STK4_MOUSE
Sequence: METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFMDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQDDEENSEEDEMDSGTMVRAAGDEMGTVRVASTMSGGANTMIEHGDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKNVSGSLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEMEEIRQKYRSKRQPILDAIEAKKRRQQNF
What is the function of this protein?
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.  Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.  Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.  Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.  Phosphorylates MOBKL1A, MOBKL1B and RASSF2.  Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).  Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner.  Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage.  Acts as an inhibitor of PKB/AKT1.  Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, MST-1, STE20-like kinase MST1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between nucleus and cytoplasm.
Protein: MED9_DROME
Sequence: MMDLSPNNQIEDRKPILTADGLVQTSNSPFEPTISQETQTSNGIGGQCHLTVDQLDIEILPIIYDIVRCVEKDPLENAVKLRESQDCNHKIFELQKRFESAREQIRQLPGIDFNKEEQQQRLELLRNQLKLKQQLIRKYKDTEF
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 9, Mediator complex subunit 9.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 9 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1523_ARATH
Sequence: MELKWVSCRKQSLFLISCLALLCLASLDTISCESTQNATDFKKRSQTVSCPPDWIIGPNQTKCYAYFKNSTSWEKSEMFCRTYGGHLASLASSKELSFVQKLCNGNVSSCWIGGRSMNSSTSGFRWSWSDPKTPQWNQSMFPKVPIRTRCGNGNGSSSCRANICIAVTNGSSSIFGERCNASHAFVCAVDSDIKCRNCHKYLVILAVVSGLILFTTFAIILWLLVYKRSKKRRKSRKVSNPASSSSVVPPSWKIFTSEELRSMTKNFSEANRLAGDAKTGGTYSGGLSDGTKVAVKRLKRSSFQRKKEFYSEIRRAAKLYHPNVVAIKGCCYDHGERFIVYEFIASGPLDRWLHHVPRGGRSLDWNMRLNIATTLAQGIAFLHDKVKPQVVHRDIRASNVLLDEEFGAHLMGVGLSKFVPWEVMQERTVMAGGTYGYLAPEYVYRNELTTKSDVYSFGVLLLEIVSGRRPTQAVNSSVGWQSIFEWATPLVQANRWLEILDPVITCGLPEACVVQKVVDLVYSCTQNVPSMRPRMSHVVHQLQQLVQPLEVK
What are the official names of this protein?
C-type lectin receptor-like tyrosine-protein kinase At1g52310.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PROX_ACESD
Sequence: MDMDAKQAVIAKLDELKINYTLIEHDPVYTIEEMEKIDIENVDYIVKNLFLRDAKGRQHYLVVADKDQKIDLKTLQDKIGSTKLSFASEDRLQKYLKLTKGAVSPFGVLNDETAEVEVVFDKNLVGRSCVAVHPNDNSATVVLSYEDLEKIVKANGNTFKAIEL
What is the function of this protein?
Functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro).  Has weak activity on correctly charged tRNA(Ala), tRNA(Gly) as well as tRNA(Cys), tRNA(Met), tRNA(Pro), tRNA(Ser) and tRNA(Leu).
What are the official names of this protein?
Prolyl-tRNA editing protein ProX, Prolyl-tRNA deacylase ProX.
What is the protein family that this protein belongs to?
Belongs to the PRORSD1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPH3_CANGA
Sequence: MSTYDQIEIEDMTFHPDSQMFTYPCPCGDRFQILLDDMFDGEAIAVCPSCSLMIDVIFEKEDLDEYYEEAGIAPPQPIAAAA
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1.  Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state.  Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM.  Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex.  The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
What are the official names of this protein?
Diphthamide biosynthesis protein 3.
What is the protein family that this protein belongs to?
Belongs to the DPH3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MUTL_CHLCV
Sequence: MSSRNPIQLLDTITINQIAAGEVIENSISVVKELVENALDAGADEIEVETLGGGQGLIVVKDNGCGMSSEDVALALKRHATSKIGEFSDVFSLSSFGFRGEALPAIASISKMEILSCPRAGEGSRTIIHGGEIVTSEAKPRQVGTTISIDSLFYNVPVRRGFQKSPQTDRMAMRKLLENRILSVENVGWSWVSERQQEFHIFKHQGFAERVAFVMGEGFMQEALRVDKGGNLVRVVGFLGSPGFHRPTRLGQRVFINDRPVDSTFISKKISEAYSMLLPPQRYPVFVLKLYLPPEWCDFNVHPQKTEVRILREEFVGEFLSETIGEVLARPQEVSVFETASTLPALRFFDEQLPESALEGLQGSNVLPVVKLTPSSSGSLPFLDREPDPLPVDRQTQISWGASQEVRFLTSLGKIVLAEDSEGVHAIFTESARKHLFYLSLVENHQHNYKSQSFLVPLCLEVTPQERIFLSSHIEEFKLLGIEISQMGPCVFSIESAPTFIGEEELKLWILSLAAESAKVDKRAMTLLIKEALTQTIFCKTLRAFDISWLSLLWQLGKPEKAFDGSQIRRLVLDEDFIKE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: DTD_BACCN
Sequence: MRVVLQRSKEASVTVDGEIVGQIPFGLTLLVGITHEDTEQDAAYIAEKIANLRIFEDENGKMNHSILDVKGQVLSISQFTLYGDCRKGRRPNFMNAAKPDYAERLYDFFNEEIRKQGLHVETGKFGAMMDVSLVNDGPVTLIVESK
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_SHIDS
Sequence: MAKEFGRPQRVAQEMQKEIALILQREIKDPRLGMMTTVSGVEMSRDLAYAKVYVTFLNDKDEDAVKAGIKALQEASGFIRSLLGKAMRLRIVPELTFFYDNSLVEGMRMSNLVTSVVKHDEERRVNPDDSKED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI2_BORAP
Sequence: MGIEPNILENKKRHIDICLNKNDVKSGCNFLRFVKLKHNALSDFNFSEIDIKEEIFGYNISMPVFISSMTGGGKEGNDFNKSLVKIANYLKIPIGLGSFKLLFKYPEYIRDFALKRYAHSIPLFANIGAVQIVEFGISRIVEMIKRLEVDAIIVHLNAGQELMNVNGDRNFKGIKESIAKLSNFISVPLIVKETGFGISPSDVKKLFQLGVSYIDLAGSGGTNWVLVEGMKGNNLNIASCFSDWGIPSIFTLLSINDSLKANIFASGGYETGMDIAKGIALGAKLIGVAAVVLRAFYDSGEDAVFSLFSDYEHVLKMSMFLSGSKSLSDFRNNKYFLSSYLLAEFGVFKQFYGT
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_PROA2
Sequence: MIRYFTAGESHGPALSAIVEGMPAGISIAPEDINDELARRQRGYGRGGRMNIETDTAAVLSGIRFGKTIGSPITLQIENRDWKNWTVKMAQFEQPEENIPAITIPRPGHADLTGMIKYGFQDIRPVIERASARETAARVAACSLAKVFLRHAGIQIGSYVSAIGPAGEIAPSPKMQELLSQGAASLSRAADASCVRMLDKENEEAAIAAIDKAKEDGDTLGGIIEVFITGVPLGLGTYVQHDRRLDAALAAALLSIQAVKGVEIGSAFDNARRPGSQVHDEMYVEDGSAPVRKTNRAGGIEGSMSNGQVIHLRAAMKPIATLMSPLHSFDLSSMEAHLSHIERSDTCAVPACSVIAEAVVAPILANALLEKTGGDHLEEILERLNAYKASIAKQFQT
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: YNDK_BACSU
Sequence: MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVDQLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRKIEKNIMKLNQAKKRRMKRK
What are the official names of this protein?
Uncharacterized membrane protein YndK.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.