PharMolix/UniProtQA huggingface dataset:
Protein: MLP_RANTE
Sequence: FIGSALKVLAGVLPSIVSWVKQ
What are the official names of this protein?
Melittin-like peptide, MLP.
What are the subcellular locations of this protein?
Secreted.
Protein: KEFF_ECO24
Sequence: MILIIYAHPYPHHSHANKRMLEQARTLEGVEIRSLYQLYPDFNIDIAAEQEALSRADLIVWQHPMQWYSIPPLLKLWIDKVFSHGWAYGHGGTALHGKHLLWAVTTGGGESHFEIGAHPGFDVLSQPLQATAIYCGLNWLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAHHG
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefC.  Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefF, Quinone oxidoreductase KefF.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SRTM1_MOUSE
Sequence: MSEADSSSGFAGSVENGTFLELFPTSLSTSVDSSSGHLSNVYIYVSIFLSLLAFLLLLLIIALQRLKNIISSSSSYPEYPSDAGSSFTNLEVCSISSQRSTFSNLSS
What are the official names of this protein?
Serine-rich and transmembrane domain-containing protein 1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MTNN_LISMF
Sequence: MTIGIIGAMEEEVELLKNSMPSVEEIVIGGAKFYVGEIAGKEVVLLESGIGKVNAALGTTLMADRFKPEVIINTGSAGGMAEGLAVGDVIISDRLAYGDVDVTEFGYTYGQVPRMPAFYQGDAVLLKKAETIYREYFAASENKAVYGLVVTNDSFIMRPDQHETIRTFFPDVKAVEMEAAAIAQVAYQFDIPFLIIRAISDLANQEATISFDEFIHLAARQSATCIIELLKTI
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: SECA_GRAFK
Sequence: MSFLDSVLKAFVGDKSKKDVKEIQPIVNKIKALESEFEALSLDELRAKTSEFKAKIAEATKEVEDKIVALNKEADEIDDITRKEDIYAEVDALKEKSYEISEAVLNDILPEAFATVKETAKRFVNNTQLKVKASSFDREISAEKDYVTLEDDHAIWSNSWDAAGKPVTWDMVHYDVQLIGGVAMHQGKIAEMQTGEGKTLVATLPMYLNALTGNGVHLVTVNDYLAKRDSAWMAPIFQFHGMSVDCVDYHRPNSAARRKAYNADITYGTNNEFGFDYLRDNMSHAPDDLVQRPHNYAIVDEVDSVLVDDARTPLIISGPVPKGDTHEFMELKPAIANIVEVQRKHLVKVLSEAKKLIKEGDTKEGGFQLLRVYRGLPKNKALIKFLSEEGIKQLLQKTENHYMQDNNREMPKVDAELYFTIEEKSNQIDLTDKGIEFLSGKDEPDFFVMPEIGMEIAKIEKEGFPAEEEAEKKEELFRDYSVKSERIHTLRQLLKSYTLFEKDTEYVVIDNKVKIVDEQTGRIMEGRRYSDGLHQAIEAKENVKIEDATQTFATVTLQNYFRMYGKLSGMTGTAVTEAGELWEIYKLDVVEIPTNRPIARNDKEDLVYKTKREKYNAVIDHVTDLSNAGRPVLIGTTSVEISELLSRMLKLRNVPHNVLNAKRHKQEADIVAEAGNSGIVTIATNMAGRGTDIKLSKEVKEAGGLAIVGTERHDSRRVDRQLRGRAGRQGDPGSSQFYVSLEDNLMRLFGSERIAKLMDRMGLEEGEVIQHSMISKSIERAQKKVEENNFGVRKRLLEYDDVMNAQREVIYKRRYHALFGERLRVDLANMIFDISESITETNKAAEDFKNFEFELIRNFSMSSPVSEEEFKKMNAQKLAGEVYKSAYKHYDEKMSHNAERAFPVIKQVHEDERNNFERISVPFTDGTKTLSVVTNLEKAYETEGKQLIKDFEKNITLAIIDDAWKTHLRKMDELKQSVQLAVHEQKDPLLIYKFEAFELFKVMLENVNRDVMSFLFKGEIPSTGAPSIHEARQTKSKEKVETRKEEIPNMDERAAQSRAAGNTQRQQPEVTETIVRDRPKIGRNDKVTVKNVMSGESKTMKFKQAIPLLDKGDWVLVEE
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: EIF3C_MEDTR
Sequence: MTSRFFYQGGDQSDTDDEPTDIDDEPSDTEPAPTDPNGKSKYLAGGNADDSDDDDGQKRVVKSAKDKRFDEMASTVDQIKNAIKINDWVSLQESFDKINKQLEKVMRVIESQKIPNLYIKALVMLEDFLAQASANKDAKKKMSPSNAKAFNSMKQKLKKNNKQYEDLIIKCRESPESEGEKDEDDEDSDEYESDDEMIEPDQLRKPEPVSDSETSELGNDRPGDDGDAPWDQKLSKKDRLLEKMFMKKPSEITWDTVNKKFKEILEARGRKGTGRFEQVEQLTFLTKVAKTPAQKLQILFSVVSAQFDVNPGLSGHMPISVWKKCVQNMLVILDILVQHPNIKVDDSVELDENETKKGDDYNGPINVWGNLVAFLEKIDAEFFKSLQCIDPHTREYVERLRDEPQFVVLAQNVQEYLESIGDFKASSKVALKRVELIYYKPHEVYEATRKLAEMTVEGDNGEMSEEPKGFEDTRIPAPFVVTLELVARKPTFPENSRTLMDVLVSLIYKYGDERTKARAMLCDIYHHALLDEFAVARDLLLMSHLQENVHHMDISTQILFNRAMSQLGLCAFRAGLVSEAHGCLSELYSGGRVKELLAQGVSQSRYHEKTPEQERLERRRQMPYHMHINLELLESVHLTSAMLLEVPNMAANVHDAKRKIISKNFRRLLEVSEKQTFTGPPETVRDHVMAATRVLINGDFQKAFDIIASLDVWKFVKNRDAVLEMLKDKIKEEALRTYLFTFSSSYDSLSVVQLTNFFDLSLPRVHSIVSRMMVNEELHASWDQPTGCIIFRNVEHSRVQALAFQLTEKLSILAESNERATEARLGGGGLDLPPRRRDGQDYAAAAAGGGSGTSSGGRWQDLSYSQTRQGSGRTGYGGGRALSFSQAGGSGGYSRGRGTGGGGYQNSGRTQGGSALRGPHGDTSTRMVSLRGVRA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 subunit 8, eIF3 p110.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_HERA2
Sequence: MARIKRGIMTHKRHKKLLNQAKGFRGSRSHNYKTAHEAVMKALAYAYRDRRNRKRDFRRLWIVRINAAARLNGLSYSNLINGLNKAGIVIDRRQLADLAVRDAAAFTAIVAQAKQALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: SYM_ECOL5
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDKYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYKTFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMKQVEALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDAGAKPGHQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDA7_ARATH
Sequence: MAAQDKYKFVFTAKEAASEGVTEPIRLPKLIRKAMSLARGPISKYKVGAVGRASSGRVYLGVNVEFPGLPLHHSIHPEQFLVTNLALNSEKGLRQLAVAISSDCIEFGAPCGNCRQFLMETSNELDIKILLKSKHEAEGSFSSLKLLLPYRFTPDDVLPKGSPLLLEKRDNCLTLSGSTEEICSSDCSHLKCKALAAANNSFSPYTESPSGVALQDDEGKWYRGWYIESVAYSPSLGPVQAALVDFVARSRGKGFNKIVEAVLVEKNNARVSQERTAKMILDTIAAPNCDFKVFHCYVDLQKKFITE
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase 7.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: SYDND_METJA
Sequence: MVNKMKWRRTHYSADIKPEMDGQEVIIMGWVHSIRALGKIIFVILRDREGTVQIVAPKQKVGDELFSQIKKLGAEDVIAVKGKVIANEKAPNGFEILPLELEVINTAKRPLPLDPAEKVPAELDTRLENRFLDLRRPKVQAIFKIRSEMLKSVRNTLYNEGFIEVNTPKLVASCTEGGTELFPISYFEREAFLGQSPQLYKQMLMATGLDRVFEIAPIFRAEEHNTRRHLNEATSIDIEMAFADDKDAMDILEKVVYNAFVDVYENRKKEIETLGIEFELPPEKFDRITYDEAIDIANAKGVEISWGEDLSREAEKAIGEEMEGLYFITDWPSEIRPFYTMPDEKNPNICKAFDLMYKDLEISSGAQRIHLYDLLVENIKKKGLNPDGFTYYLEAFKYGMPPHAGWGLGADRFTMVLTQQENIRECVLFPRDRQRLTP
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_HALLT
Sequence: MNINDTVERVTDGADLTVDEAREAARLVFEEATEAQIGALLAALRAKGETEAEIAGFAQGMRDAARTIEPDREPLVDTCGTGGDDYDTINVSTTAAIVAAGAGVPIAKHGNYSVSSSSGSADVLEVAGADVEAEPPAVEEAIETDGIGFMLAPVFHPAMKAVIGPRKELGMRTIFNVLGPLTNPAGADAQVLGVYDPDLVGTIARSLAHMPVEHALVVHGAGMDEIGIHDETVAAEVDGDEVREFTIAPEDLGLDRAPIEAVSGGTPEENAADLRGIVDGSVTGPKRDLILANAGAAIYVAGETDTLAAGVERAAEAIDSGAAATKFAALCGDDEAVEGDGEAASTDSAAASTTAGPEDDD
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: PHNS_SALCH
Sequence: MKLSRLALLSVFALASAPSWAESVVTVYSIDGLHDGDNSWYQVQFDAFTKATGITVRYVEGGGGVVVERLAKERTNPQADVLVTAPPFIQRAAAEKLLANFNTDAASAIPDANNLYSPLVKNYLSFIYNSKLLKTAPASWQDLLDAKFKNKLQYSTPGQAADGMAVMLQAFHSFGSKDAGFAYLGKLQANNVGPSASTGKLTALVNKGEIYVANGDLQMNLAQMERNPNVKIFWPANDKGERSALAIPYVIGLVQGAPQSENGKKLINFLLSKEAQTRVSELSWGMPVRSDVTPSDEHYKAATAALEGVQSWQPNWDDVAVSLSADISRWHKVTESE
What is the function of this protein?
Probably part of the PhnSTUV complex (TC 3. A. 1. 11. 5) involved in 2-aminoethylphosphonate import.
What are the official names of this protein?
Putative 2-aminoethylphosphonate-binding periplasmic protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: LCE3E_HUMAN
Sequence: MSCQQNQKQCQPPPKCPSPKCPPKNPVQCLPPASSGCAPSSGGCGPSSEGGCFLNHHRRHHRCRRQRSNSCDRGSGQQGGGSGCCHGSGGCC
What is the function of this protein?
Precursors of the cornified envelope of the stratum corneum.
What are the official names of this protein?
Late cornified envelope protein 3E, Late envelope protein 17.
What is the protein family that this protein belongs to?
Belongs to the LCE family.
Protein: OBG_BRAHW
Sequence: MDQFIDVVSFEIEAGHGGAGSVSFRREAHVPMGGPDGGNGGDGGDVIVRVDARINSFGKIKSRKRFRARDGEPGRARLSDGKRGDDVVIRVPIGTVVYDEDTNNILADLLEDGQSYTVARGGKGGKGNKFYATATNQAPDYAQHGLDGEKLNIRLEVKLIADIGLVGMPNTGKSSLLARLTRANPKIASYPFTTLTPNLGVCYLDYERSFVIADIPGIIEGASEGAGLGLTFLRHIERTGALCFVIDLTDEDVADTYKKLRNELKQYSKELIKKKSIIVLNKTDMLEKDEIKAKVKAIEKAVKKEYKNNKETHYEEPEIFALSVFSLDGDMLDKVTNAFYKANEERYDNTKKETKEPLLLNQNKTKSKLKTKRVFGPVVSKRLGNSLGIDVIPHKTCSYNCIYCQLGSEENTKTSLANYYSVDEIIYELKEALLNNKNIDYITFAGSGEPTLYKDLKKLIYEIKQITDIPVCIITNGSLLYKQEMRSDLLIADLVIPSLDAGNMDTFKLIDQPNKEIDFDKMVNGLIEFRRVFKGEYWLEVFLLKDINDSKEELDDIIKIVNKIKPDRVQLVTATRRTSNEKAKALNDEEMEKAKKYFEANCSIEIDVPSVSDKAKGNTKKITEEDIINFLIRQPDTVHMIAISFNEDESRVSELLKKLVESGKVREEIVNGVLSYAVNI
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH1L_ECOL6
Sequence: MKNTELEQLINEKLNSAAISDYAPNGLQVEGKETVQKIVTGVTASQALLDEAVRLGADAVIVHHGYFWKGESPVIRGMKRNRLKTLLANDINLYGWHLPLDAHPELGNNAQLAALLGITVMGEIEPLVPWGELTMPVPGLELASWIEARLGRKPLWCGDTGPEVVQRVAWCTGGGQSFIDSAARFGVDAFITGEVSEQTIHSAREQGLHFYAAGHHATERGGIRALSEWLNENTDLDVTFIDIPNPA
What is the function of this protein?
Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides.
What are the official names of this protein?
GTP cyclohydrolase 1 type 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
Protein: METXS_HALHL
Sequence: MVRSPPTDSVGLVTQHKATFEEPLPLVCGRELPRYELVYETYGELNREGTNAILVCHALSGNHHAAGYHSEHDRKPGWWETCIGPGKPLDTNRFFVVCSNNLGGCHGSTGPASINPETGKPYGDQFPIVTVRDWVRSQARLADELGIRQWAAVAGGSLGGMQAMQWAIDYPERLRHAIVIAAAPRLSAQNIGFNEVARQAIMSDPEFHGGRYYDYGVSPRRGLAVARMLGHITYLSDDAMRAKFGRDLRGDMSFDFEQVDFEVESYLRYQGQRFVQDFDANTYLLMTKALDYFDPAADHDDDFSAALAHIQCSTLLLSFSSDWRFAPARSREILRALLEHNKPVSYMEIEATQGHDAFLMPIQRYLEAFSAYMGNVAREVGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTUC_KLEP7
Sequence: MESMLTLAHLQQRRSRRWLFGLTLLLLVTLLISLCAGEQWIPPGEWLSAKGQLFIWQIRLPRTLAVLLVGAALALSGAIMQALFENPLAEPGLLGISNGAGVGLIAAVLLGKGVLPGWALGLCAIFGALLITFILLRFARRHLSTSRLLLAGVALGIICSALMTWAVYFSTSFDLRQLMYWMMGGFGGVDWQQLWLMIALLPVLCWVCLQSQPLNLLALGEVSARQLGLPLWLWRKLLVVATGWMVGVSVALAGAIGFIGLVIPHILRLCGLSDHRVLLPACMMAGASALLGADIIARLALSAAELPIGVVTATLGAPVFIWLLLRSRGRG
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Involved in the translocation of the substrate across the membrane.
What are the official names of this protein?
Vitamin B12 import system permease protein BtuC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KTHY_PECAS
Sequence: MNSKFIVIEGLEGAGKTTARNIVVETLRSHGVKEVLFTREPGGTPLAEKLRELIKQGMADEKVTDKAEVLMLYAARVQLVDNVIKPALADGKWVIGDRHDLSSQAYQGGGRGIDQQLLRSLRDTVLGNFRPDLTLYLDLPPAIGLQRARQRGELDRIEQESLAFFDRTRTRYQALAAEDDSILTIDASQSIDAVSADIQAALQQWLQQQGLQPVVQVQY
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: KAE1B_HALWD
Sequence: MRILGIEGTAWAASAALYNTHDETIVIESDPYQPDSGGLHPREAAEHMSTALPEVISTILERAVSSGNTDAIGIDAIAFSRGPGLGPCLRVVGTAARTLTQALSVPLIGVNHMIAHLEIGRHQSGFTTPVCLNASGANAHLLGYHRRQYQVLGETMDTGVGNAIDKFTRHLGWNHPGGPKVEAAATDGSYHDLPYVVKGMDFSFSGIMSAAKDAVDNEVPVVDVCTGLQETIFAMLTEVAERALSLTGSNELVLGGGVGQNDRLREMLSTMCTARGASFYAPESRFLRDNAGMIAVLGAAMYEAGQTISVNDSAVDPTFRPDAVTVTWRDDETSVTRTPATLDKTPVRGAEAIVRRINDHVVKRRVEKSYRHPKLDRRLRAERTRAEARLTSAARRLGVPTPLIFDADPETGTLVFEYVGETDLAADLTVSRCHAVGQHLGRIHNAGFVHGDPTTRNVRVDSAQNYLIDFGLGYHTDHVEDHAMDLHVFIQSVTGTASDPAPLITAFESGYAETGISTVQSRLRDIESRGRYH
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  The Kae1 domain likely plays a direct catalytic role in this reaction.  The Bud32 domain probably displays kinase activity that regulates Kae1 function.
What are the official names of this protein?
Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_BURVG
Sequence: MRILLSNDDGYLAPGLAALSDALQPLADVTVIAPEQNCSGASNSLTLSRPLSVQRAANTGFFYVNGTPTDSVHVALTGMADARPDLVVSGINNGQNMGEDTLYSGTVAAATEGIMFGVPAIAFSLADKGWAHLADAARVAAEIVAHYLAHPLPGQPLLNVNIPNLPYDALKGWQVTRLGKRHPSQPVIRQTDPRGEPVYWIGAAGAALDASEGTDFHAIANGFVSITPLQLDLTHTQMLPATRDWARAAGRAS
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPC3_BOVIN
Sequence: MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLIQHNLVTYQVHKRGVVEYEAQCNRVLRMLRYPRYIYTAKTLYSDTGELIVEELLLNGKMTMSAVVKKVADRLTETMEDGKTMDYAEVSNTFVRLVDTHFVQRCPLVPATENSDTGPPPPAPTLVVSEKDMYLVPKLSLIGKGKRRRSSDEDATGEPKAKRPKQTTDNKEPIPDDGIYWQANLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEVTTPSGAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPLEFVGKSGDSGGGMYVINLHKALGSLATATLESVVQERFGSRCARIFRLVLQKKHLEQKQVEDFAMIPAKEAKDMLYKMLSENFISLQEIPKTPDHAPSRTFYLYTVNILSAARMLLHRCYKSVANLIERRQFETKENKRLLEKSQRVEAIIASMQATGAEEAQLQEIEEMITAPERQQLETLKRNVNKLDACEIQVDETIFLLESYIESTMKR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F.  May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation.  Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.  Acts as nuclear and cytosolic DNA sensor involved in innate immune response.  Can sense non-self dsDNA that serves as template for transcription into dsRNA.  The non-self RNA polymerase III transcripts induce type I interferon and NF-Kappa-B through the RIG-I pathway.  Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner.
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC3, RNA polymerase III subunit C3, DNA-directed RNA polymerase III subunit C.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RFPLA_HUMAN
Sequence: MAEHFKQIIRCPVCLKDLEEAVQLKCGYACCLQCLNSLQKEPDGEGLLCRFCSVVSQKDDIKPKYKLRALVSIIKELEPKLKSVLTMNPRMRKFQVDMTFDVDTANNYLIISEDLRSFRSGDLSQNRKEQAERFDTALCVLGTPRFTSGRHYWEVDVGTSQVWDVGVCKESVNRQGKIVLSSEHGFLTVGCREGKVFAASTVPMTPLWVSPQLHRVGIFLDVGMRSIAFYNVSDGCHIYTFIEIPVCEPWRPFFAHKRGSQDDQSILSICSVINPSAASAPVSSEGK
What are the official names of this protein?
Ret finger protein-like 4A, RING finger protein 210.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: KAD_THET2
Sequence: MDVGQAVIFLGPPGAGKGTQASRLAQELGFKKLSTGDILRDHVARGTPLGERVRPIMERGDLVPDDLILELIREELAERVIFDGFPRTLAQAEALDRLLSETGTRLLGVVLVEVPEEELVRRILRRAELEGRSDDNEETVRRRLEVYREKTEPLVGYYEARGVLKRVDGLGTPDEVYARIRAALGI
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_BUCCC
Sequence: MKLRPLHDRVIVKRNEVELKSAGGIVLTGSAAGKSTRGVVLSVGKGRILDNGSIKKLDVKVGDIVIFNEGYGAKTETINNEEVLILTENDILAIVEK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_EXIS2
Sequence: MRWNQVDPQAHVEVLVVGISGNQPVEERIRSLYPDRLDEWVRRGDISTKQGELRLLPTLTGTVERVLFVGLGKAEGLTTDGLRRLFGKAAQFLKARQLSKVTIDATTFPDQPVELIAETFGLSTYEVKHYKTNTRATYDLDVTIWSDAGEQAVERGAALAQATNLARRLVTMPGNLLTAPALADEARFIAERHGHELKILEKADMEALGMGALLAVNQGSTIPPKLIVLEYKGAGDDAPIAVVGKGVTFDTGGYSIKPKDGIVGMKGDMGGAAAVLGLFEALGHLKPNVNVLGVIPATDNMISGDAFKPDDVITSMAGKTIEILNTDAEGRLVLADAVTYAKEYKPKMIIDLATLTGGVLVALGTEITGALTNDAGLYERFEAVTKETNEMVWQMPYVDQFIKQVRRSDVADLNNSPGRMGHMIFGGAFVGEFVGDTPWLHLDIAGTSEQKAATELGPKGATGVMVRSLYHFVEREK
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADD_SHELP
Sequence: MIDTSIPLVDLHRHLDGNVRVETIWDLGHQHNIALPADTLEGLAPFVQIQGKESSLVAFLKKLDWMVAVLADLDAVKRVAYENVADAAISGLDYAELRFSPYYMAMNHKLPIEGVVEAVIDGVKAGLKDYEVKINLIGIMSRSFGQDACMQELEALLAHKQHLVAMDLAGDELGFPGALFNDHFKKVRDAGLAITAHAGEAAGAESMWQAIQELGATRIGHGVNAIHDPKLMEYLAANRIGIESCPTSNLHTSTVTSYQEHPLRTFMEAGVLIGLNTDDPGVSAIDIKHEYRTVKQEMGFSDAELAQLQRNGVEMAFISDSERKALYAAKA
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.