PharMolix/UniProtQA huggingface dataset:
Protein: NQO9_PARDE
Sequence: MAFDFARATKYFLMWDFIKGFGLGMRYFVSPKPTLNYPHEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAVCPAQAITIDAERREDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEYATETREELFYDKQKLLANGERWEAEIARNLQLDAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit 9, NADH dehydrogenase I subunit 9, NDH-1 subunit 9.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CSRP2_COTJA
Sequence: MPNWGGGNKCGACGRTVYHAEEVQCDGRSFHRCCFLCMVCRKNLDSTTVAIHDAEVYCKSCYGKKYGPKGYGYGQGAGTLNMDRGERLGIKPESSPSPHRPTTNPNTSKFAQKFGGAEKCSRCGDSVYAAEKVIGAGKPWHKNCFRCAKCGKSLESTTLTEKEGEIYCKGCYAKNFGPKGFGYGQGAGALVHAQ
What is the function of this protein?
Interacts with zyxin.  May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.  Totally down-regulated in transformed cells.
What are the official names of this protein?
Cysteine and glycine-rich protein 2, Cysteine-rich protein 2, CRP2.
What are the subcellular locations of this protein?
Nucleus.
Protein: LDT4_MYCTU
Sequence: MPHWAEERHRRESNYVALEAGLDEGESIRRSEHSRSGCGADAGCWRCRGGPGRGSRRSRRSRGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDPLAPPPPDPLAVPVAAGPVAGQDPTSFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVPIADRAMAESAIHISSIPPVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRTGDSLVATADDATHQMTITRNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDSSTYGVPVNSAQGYKLTVSDAVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAKWFYDNFGSGDPVVVKNSVGTYNKNDGAQDWQI
What is the function of this protein?
Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem.  Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.
What are the official names of this protein?
L,D-transpeptidase 4, LDT 4, Ldt(Mt4).
Protein: DAPF_YERP3
Sequence: MQFSKMHGLGNDFMVVDAVTQNVYFSPELIRRLADRHTGVGFDQMLVVEPPYDPELDFHYRIFNADGSEVSQCGNGARCFARFVRLKGLTNKREISVSTQTGRMILSVTEDEQVCVNMGEPDFEPQTVPFRAAKAEKTYILRAAEHTVLCGVVSMGNPHCVMQVDDVSVANVALLGPVLENHERFPERANIGFMQVVSRDHIRLRVYERGAGETQACGSGACAAVAVGVVQDLLNENVHVELPGGSLHIRWQGPGHPLYMTGPATHVYDGFIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_NEIMA
Sequence: MSEELQPVFSIERLYVKDLSLEVPHAPQIFLEQGEPEVDMRVSTGSQKLEDGYYNVDVTVTVTAKLDNERTMFLNEVTQSGIFRLENIPEEDADLLLGVACPNILFPYAREAVSGTVTRAGFPPVLLAPINFEAIYQQQQEAEAAGA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: I36RA_MOUSE
Sequence: MMVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAEKVIKGEEISVVPNRALDASLSPVILGVQGGSQCLSCGTEKGPILKLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTSPEADQPVRLTQIPEDPAWDAPITDFYFQQCD
What is the function of this protein?
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling.  Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor.  Proposed to play a role in skin inflammation.  May be involved in the innate immune response to fungal pathogens.  May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
What are the official names of this protein?
Interleukin-36 receptor antagonist protein, IL-36Ra, Interleukin-1 HY1, IL-1HY1, Interleukin-1 delta, IL-1 delta, Interleukin-1 family member 5, IL-1F5, Interleukin-1 homolog 3, IL-1H3, Interleukin-1-like protein 1, IL-1L1.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: RL16_XANOR
Sequence: MLQPKRTKYRKMHKGRNDGLAWSGNAVSFGEYGLKATAHGQLTARQIEAARRTISRHVKKGGKMWIRVFPDKPITKKPIEVRMGSGKGNVEYWVAQIQPGRMIYEIEGIPEETAREAFRLAAAKLSVTTTFVTRTVR
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: ARGB_METS3
Sequence: MKDVNILVEALPYIKKFHEKKILIKYGGHAMIDEDAMSSTVRDTVLLKYVGMEPLIVHGGGPEISRSMDKLGKEPKFIKGLRVTDEETMEIIEMVLVGKISTDIVSQISYHDGKGISLSGKDSRLIFAHKKPVSKVTSESGGEEEIDLGLVGEIDCINTDLLEMFLKNNYIPVISPVGIADDGSSLNLNADTAAGEIASSVDAEKLIILTDVPGVLRDPNDPDSLIQRIKIDEVPDLIEEGVISGGMIPKIETCVKAIEDGVKSCHIIDGRKKHSLLLEIFTKNGIGTMIYK
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_GEOSD
Sequence: MAHPSQLGFQDAASPMMEELLHFHDHALMVVFLISTFVLYIILTMLTTKLTDKLILESHEIEII
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CFA53_DANRE
Sequence: MLTAQRSRIRCREITGPAHSVALKARPPLSRDIDDIFVRRRKQEATRGEVLEFTKDQSSCDVRMRWERNTQRRVVSATVNRHLQDALDQYQMGIDEKRERLRELLESEELELFKEMEAKKETVLERQAKMHERAKTLRERRESERQRVVADKLDQLFREQSEELRAVQIKRRQDQVCTERESQIRTKEEVRRVQEEEEKLFAQMWESDRLAKEERHNLELQRQRENNLQQKAVLQTQMDMAEQQRIQAKELKQEEAQLLKDQREMLRLEAEREHRQKLQDQEKRRKQLDLSLRLKMKRLTRDRQEELALDMSILEQLLAQEKDEKQDEVLKKLERQEEQRRYREYLSQQLEEQKRLEAETEQLFESELQQAWARREAQWRLEKTARDRLMKDVMDTLRLQIQEKLNENMQKQAEAFKEKEELDRIIQANKLLDEEEKAHFREATKEYQADLLAQMMYRQRIREAEEAEKEYEFQKGLMYEEQYNKKIQDILSRPISSTTAVHPFRRRDRRCSSSGGQMS
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).  May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis (PubMed:26531781).
What are the official names of this protein?
Cilia- and flagella-associated protein 53.
What is the protein family that this protein belongs to?
Belongs to the CFAP53 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: MAUG_METME
Sequence: MLFRHLVLIISTLMVANTAWSANLPPREKFKRPDSIPAPLSNPLTLEKATLGKTLFFDQRLSRSGGMACATCHSPDQRWSDGRTLPLQAESVSNARRTPTVLNSAWLSALMWDGRATTLEEQAVLPITTAHEMNFDLASLVSRLQRIEGYRPLFTQAFGDDSISQQRITQALASFQRTLVSNIAPFDRWVAGDEQAISESAKRGFAVFNDKNKANCVACHSSWRFTDDSFHDIGLPSKDLGRGAKVPSQVTLMQHAFKTPSLRDLSIDGPYMHDGSIRGLKTVIKHYKSEAIQRESLSKDMQKFELSNLEESDLIAFIQSLDGGALKIQAPMMPE
What is the function of this protein?
Involved in methylamine metabolism.  Essential for the maturation of the beta subunit of MADH, presumably via a step in the biosynthesis of tryptophan tryptophylquinone (TTQ), the cofactor of MADH.
What are the official names of this protein?
Methylamine utilization protein MauG.
What are the subcellular locations of this protein?
Periplasm.
Protein: CLPP_XANOR
Sequence: MSIVTKALNLVPMVVEQTSRGERAYDIYSRLLKERLIFLVGPIDDHMANVIVAQLLFLEADNPEKDISIYINSPGGVVTAGMAIYDTMQYIKPDVSTICVGQAASMGALLLASGAAGKRYALPNSRVMIHQPLGGFQGQATDIDIHAREILTLRSRLNEILAKHTGQSLETIARDTERDNFKSAVDAQAYGLVDQVLERRPEESIQPS
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NO66_BRUMA
Sequence: MIKGKRSFPKRQNNVRVLNSSRVEEFDISDHNQSIDSINELSAYEVLSLRKKTEDGIKSNLNEERVASSLTSRAEDNKPCRDFVKSDRNVLASDFLSKYGEETDEMNKTKKKQKKIMKKEIRKRTKRKRKSVNKRELSGSIKTWIPTHSGSSVFSSLFRNCDDSKEMXDSIVDCLSEGEEIEEIKIVNLSDSSHGSSFESDEINEDKNMVDEEENDEELIDERSTNSAVRENFVRCYGKEKDEDASDVVIDFEQKPFSTHCDSVQNGLDAIQWLIDPYDLTQFFKMVFQKKVFLVCHNNPNYYGNLFSTAKFIDILQTDYVEYGTNVNVAIYKNQQRSTLNGSGKVYPQAIQKSIKAGCSIQLTNPQSFCDNVWYYCDLLQEVFGCFVGANIYITPANTAGFAPHWDDIDAFLLQLEGRKHWKIYAPDSDDEMLPRLPSGNFTDNDVINRMLVFDDWLEQGDMLYIPRGYIHQGFADKDVHSLHLTVSVCRNVTYADLLERVIPPALSNFAEQNVNIRKSLPARYLDMTGVLECDYPLLKTGTMKLHRFLDSIFSNFCKYIKELSEPAVDMMAREFMRTALPPVLTKEEKDMTALCVAGSSLYGDKEHIFTKNTSIKLLRRHGQRLIYESEERCFIVHRMANSRVYEGRPEVLFDLDVELAEGFANLVNAYPRWCLVSDLKCNDAADNIRLAELLYSNGLLMAEFREAMK
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.  Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
What are the official names of this protein?
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Histone lysine demethylase NO66.
What is the protein family that this protein belongs to?
Belongs to the ROX family. NO66 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YMGG_ECO7I
Sequence: MKKKILAFGLISALFCSTPAMADMNRTTKGALLGAGVGLLTGNGVNGVLKGAAVGAGVGAVTEKGRDGKNARKGAKVGAAVGAVTGVLTGNGLEGAIKGAVIGGTGGAILGKMK
What are the official names of this protein?
UPF0757 protein YmgG.
What is the protein family that this protein belongs to?
Belongs to the UPF0757 family.
Protein: KGUA_MYXXD
Sequence: MNANTVLPPGLLLVLSAPSGAGKTTLAHRLLKETPDAVFSISVTTRRPRGKEREGVDYNFVDVATFQSKIERGEFVEWAEVYGHFYGSPQSVVDEARARKSAAIFDIDVQGGQAIKRKHPDAVTIFVLPPSMEELERRLRDRQTDSDETIRRRMLAARSEIERGIASYDYVVVNDDFERAFSDLRSVVVAERCRRERVDVSKLGLGIGG
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_AROAE
Sequence: MSGFSQERLMQVLLAPQISEKATYVADKNEQVVFKVASTATKPEVKAAVELLFKVEVKSVQIANVKGKVKRFGKMTGRRKDWKKAFVCLKPGQEINFAAGE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: CCME_CERS4
Sequence: MKGLKKKRRIQIIALAFVALAGSTALIGYAMRDGINFFRSPTQVVEAPPPETEVFRIGGLVEKGSLVRGQGETVTFRVTDTNATVPVSFTGVLPDLFAEDAGMVGTGRLVGGVFEASEILAKHDETYMPKEVVDALKEQGVFQHTEDQPQG
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: NADE_PECCP
Sequence: MSLQNDIITALGVKSSIEPAQEIRVSVDFLKNYLNAHPFVTSLVLGISGGQDSTLTGKLCQTAITELRNETGNARYQFIAVRLPYGVQADEADCQDAIAFIQPDRVLTVNIKPAIEASEATLRAIGVELSDFVKGNEKARERMKAQYSIAGMNAGLVVGTDHAAEAVTGFFTKYGDGGTDINPIFRLNKRQGKALLRELGCPSHLYTKAPTADLEEDRPSLPDEVALGVTYEKIDDYLEGKQIEAKDAAIIENWYRKTEHKRRPPITVFDDFWR
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: YT91_CAEEL
Sequence: MSTDGNNNKKGSKEGPKSSEISKFDLAKENPKLAEWMDDCIKRMNSLYKDTNINICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIPPPLPEGTKAKAAPAIAIDPNIDAARADKDAIKPFVKE
What are the official names of this protein?
Putative serine/threonine-protein phosphatase C06A1.3.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
Protein: TECT2_MOUSE
Sequence: MGSLSPLSLLWGLLLLQGVLRPLRGDPVFIPPFIRMSSPEVRATLVGGSEDVAVSLSLLQVEEGVLPVPTCGGRRNETVDWNVTVSPRESTLEVTIRWKRGLDWCSADETASFSEPPCVLQMLLVSASHNASCLAHLLIQVEIYPNTSVTHNASENMTVIPNQVYQPLGPCPCDLTAKACDIQCCCDQDCQPEVRELFAQSCFSGVFGGHVSPPSHHHCAVSTTHQTPDWFPLLCVQSPPSTSPFLGHFYHGATSPRHSPGFEAHLHFDLRDFADASYKQGDPIMTTEGYFTIPQVSLAGQCLQDAPVAFLRNFDSVCTMDLEVHQGRDEIVLENMKIRTTGGPVTPTVTYEEAIDLDKFITSPDTVLSVGSAPRNVNVEEHYVFRWQNNSISGLDITVIRAEISAQQRGMMTQRFTVKFLSHHSGGEKEFSGNPGYQLGKPVRALHTAGMNVSTLHLWQPAGRGLCTAAALRPILFGENAFSGCLLEVGIKENCTQLRENVLQRLDLLTQATHVARRGNSDYSDLSDGWLEIIRAEAPDTGADLPLSSVNGVCPEVPARLSIRILTAEAGSVEGVAQREILAVETRFSTVTWQYQCGLTCEDKADLLPLSASVEFINVPAQMPHPPTRFQINFTEYDCTRNELCWPQLLYPLTQYYQGEPQSQCVAKGLMLLSLLMLAILLRHPWVRMCKARDSAAIYH
What is the function of this protein?
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.  Required for hedgehog signaling transduction.
What are the official names of this protein?
Tectonic-2.
What is the protein family that this protein belongs to?
Belongs to the tectonic family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Protein: DCTA_JANMA
Sequence: MKKPPLYKSLYAQVIVAIIIGVLLGHFLPETGTAMKPLGDGFIKLIKMIIAPVIFCTVVIGIAGMEDMKKVGKTGGLALLYFEVMSTVALLVGLIIVNVLQPGAGMNVDVSTLDTASLASYTAPGKLETVTEFAMHIIPMSMIDAFAKGDVLQVLLVSVLFGFALQKLGGRGTLVFDFIEKISHVLFTIVGFIMRAAPVGAFGAMAFTIGKYGISSLLSLGKLMGAFYLTCLFFIFVVLGIVTRLHGFSIWKFVKYIKEELLIVLGTSSSESVLPRMIAKMENMGAKKSVVGLVIPTGYSFNLDGTAIYLTMAAVFIAQATNTPMSLMQQVTLLAVLLLTSKGAAGITGSGFIVLAATLSAVGHVPVAGLALILGIDRFMSEARALTNTIGNGVATLVVAKWVGDLDMDKLHAELDNESPQAADQPEKILDQTNTKLGA
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROL_SHIDS
Sequence: MTQPLFLIGPRGCGKTTVGMALADLLNRRFVDTDQWLQSQLNMTVAEIVEREEWAGFRARETAALEAVTAPSTVIATGGGIILTEFNRHFMQNNGIVVYLCAPVSVLVNRLQAAPEEDLRPTLTGKPLSEEVQEVLEERDALYREVAHIIIDATNEPSQVISEIRSALAQTINC
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CATA_METBF
Sequence: MGEKNSSKVLTTGFGIPVGDDQNSLTAGNRGPVLMQDVHLLDKLSHFDHERIPERVVHAKGAGAGGYFEVTADVTKYTKAKFLSEIGKRTEVFVRFSTVGGEKGSADSARDPRGFAVKFYTEDGNYDLVGNNTPVFFIRDPLKFPDFIHTQKRNPATNCKDPDMFWDFLSLTPESIHQVTILFSDRGTPATYRNMNGYSSHTYKWYNEKGEYFWVQYHFKTDQGIKNLTLEEAEKIGGSDPDHATRDLYEAIKKGDYPSWTLEMQIMTPEQAEDYRFDIRDITKVWPHGDFPTMKIGKLVLNRNPTNYFAEVEQAAFSPANLVPGIGISPDKMLQGRVFSYHDTHIHRLGPNYNLIPVNAPKYSPENSYQRDGFMRVDANGGSGPNYWPNSFGGPSPDSVYLEPPFGVSGLAARTLYTHPNDDFVQAGNLYRDVMTDYDRENLVGNIVSHLSAAQKRIQLRQTALFFKADRDYGSRVAKGLELDIKEVERLANMTNEERARATER
What is the function of this protein?
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
What are the official names of this protein?
Catalase.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
Protein: RL4_BUCCC
Sequence: MELMFQDTNEIYNISESIFNKVFNEPLVHQIIVCYLARRRQGSKAQKSRSEVSGSGKKPWRQKGTGRARSGSLRSPIWRSGGVTFAAKPKKYKLKMNKKMYRYAIKSILSELIRQNRFFLFKEFIIEFPKTKILLKKLELINLKSVLIITAHKNTSLLYASRNLYHVCVINVKSINPVILISYEKVLITLSAIKKIEVMFK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: TM128_HUMAN
Sequence: MDSSRARQQLRRRFLLLPDAEAQLDREGDAGPETSTAVEKKEKPLPRLNIHSGFWILASIVVTYYVDFFKTLKENFHTSSWFLCGSALLLVSLSIAFYCIVYLEWYCGIGEYDVKYPALIPITTASFIAAGICFNIALWHVWSFFTPLLLFTQFMGVVMFITLLG
What are the official names of this protein?
Transmembrane protein 128.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NRAM_INBME
Sequence: MLPSTIQTLTLFLTSGGVLLSLYVSASLSYLLYSDILLKFSPKITAPTMTLDCANASNVQAVNRSATKEMTFLLPEPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNNYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMGMELYVKYDGDPWTDSDALAPSGVMVSIKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: ENO_ROSCS
Sequence: MADTTIEAITAREVLDSRGNPTIEVDVYLESGDMGRAIVPSGASTGAFEALELRDGDKSRYGGKGVLKAVENVNTTIAEALEGEDAADQMRIDRMLIDLDGAENKGRLGANAILGVSLACAKAAAAAHGLPLYRYLGGIHAHVLPVPMMNILNGGKHAQNSTDFQEFMIMPVGAPSFREALRWGSEIYQSLKKVIHDRGGSTNVGDEGGFAPSLPTNEAALQIIVEAVERAGYQLGDQVMLAMDPACTELYKDGKYHLEREGRSLTSAEMVEYWADIAARYPLISLEDGLAEEDWEGWKLLRARLGDRIQLVGDDFLVTNVKRLARAISEQAANSILIKLNQIGTLTETLDAITMANRAGWTAVVSHRSGESEDVTIADLVVATNAGQIKTGAPARTDRVAKYNQLLRIEEELDSAAHYAGMGAFRVAR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RS15_CLOBK
Sequence: MDKAKKQELMAKHARHEGDTGSPEVQIALLTERINHLNSHLKEHKKDHHSRRGLLMMVGKRRGLLNYLMREDIERYRAIIKELGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.