PharMolix/UniProtQA huggingface dataset:
Protein: ARC_MYCLB
Sequence: MGESERSEAFNPPREAGMSSGDIAELEQLRREIVVLREQLEHAVGPHGSVRSVRDVHQLEARIDSLTARNSKLMDTLKEARQQLLALREEVDRLGQPPSGYGVLLAAHDDETVDVFTSGRKMRLTCSPNIEVASLRKGQTVRLNEALTVVEAGTFEAVGEVSTLREVLADGHRALVVGHADEERIVCLAEPLVAENLLDGVPGALNDDSRPRKLRPGDSLLVDPKAGYAFERVPKAEVEDLVLEEVPDVSYQDIGGLTRQIEQIRDAVELPFLHKELYREYALRPPKGVLLYGPPGCGKTLIAKAVANSLAKKMAEVRGDDAREAKSYFLNIKGPELLNKFVGETERHIRLIFQRAREKASEGTPVIVFFDEMDSIFRTRGTGVSSDVETTVVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAQDIYSKYLTESLPVHADDLTEFDGDRAACIKAMIEKVVDRMYAEIDDNRFLEVTYANGDKEVMYFKDFNSGAMIQNVVDRAKKNAIKSVLETGQPGLRIQHLLDSIVDEFAENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKSSSASRAIDTESNLGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Mycobacterial proteasome ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: NU2M_MYOSI
Sequence: MNPLTLSLVLTTMMAGTLIVMTSSHWFMIWVGFEMNMLAIIPLLTKEHNPRSTEAATKYFLTQATASMLLMMAAITNLLYTGHWSIMKLINPTASIMMTMALTMKLGLSPFHFWVPEVTQGIPLMSGLILLTWQKLAPLSGLYMIMPLINTDILLIMSLMSIAIGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTMTLLNLYIYIPMTITTFMLLMINSTTTTTSLSQTWNKLPLITTLILITMLSLGGLPPLTGFLPKWAIIQEMTKNSSIIMPTLMTLLALLNLYFYTRITYTTSLTMFPTANNMKIKWQFKNPKQMMSLPLMIMISTLVPPLAPMMPILT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RBGPR_HUMAN
Sequence: MACSIVQFCYFQDLQAARDFLFPHLREEILSGALRRDPSKSTDWEDDGWGAWEENEPQEPEEEGNTCKTQKTSWLQDCVLSLSPTNDLMVIAREQKAVFLVPKWKYSDKGKEEMQFAVGWSGSLNVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDPVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASVGIMTLSPFDQMKTASNIGGFNAAIKNSPPAMSQYITVGSNPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAVQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQIGWIQTVEDLHERVPEKADFSPFGNSQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIMGLNNVTSQSWQPQTYQICLVDPVSGSVKTVNVPFHLALSDKKSERAKDMHLVKKLAALLKTKSPNLDLVETEIKELILDIKYPATKKQALESILASERLPFSCLRNITQTLMDTLKSQELESVDEGLLQFCANKLKLLQLYESVSQLNSLDFHLDTPFSDNDLALLLRLDEKELLKLQALLEKYKQENTRTNVRFSDDKDGVLPVKTFLEYLEYEKDVLNIKKISEEEYVALGSFFFWKCLHGESSTEDMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSICCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRTACIQSENNGAALLSAHVGHSVAAQISNNMTEKKFSQTVLGADSEALTDSWEALSLDTEYWKLLLKQLEDCLILQTLLHSKGNTQTSKVSSLQAEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANEERDAENPDEPKEGVNRSFLEVSEMEMDLGAIPDLLHLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKQIFNAHVQNGIALMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDVGMSDTAMTSFLGSCLDLLQILMEADVSRDEIQVPVLDTEDAWLSVEGPISIVELALEQKHIHYPLVEHHSILCSILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQAQHSATKVKDPTEEATPTPFGKDQDWPALAVDLAHHLQVSEDVVRRHYVGELYNYGVDHLGEEAILQVHDKEVLASQLLVLTGQRLAHALLHTQTKEGMELLARLPPTLCTWLKAMDPQDLQNTEVPIATTAKLVNKVIELLPEKHGQYGLALHLIEAVEAISLPSL
What is the function of this protein?
Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:9733780, PubMed:24891604).  As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity).  Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity).  The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604).  Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604).  Required for normal eye and brain development (By similarity).  May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity).
What are the official names of this protein?
Rab3 GTPase-activating protein non-catalytic subunit, RGAP-iso, Rab3 GTPase-activating protein 150 kDa subunit, Rab3-GAP p150, Rab3-GAP150, Rab3-GAP regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the Rab3-GAP regulatory subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
Protein: IF2P_METHJ
Sequence: MGKKEVKKNKNEGDTPHIRTPIVCVLGHVDHGKTSLLDRIRGSSVVAGEAGAITQHIGATIVPIDSIMSMSGGMKNLNISIPGLLFIDTPGHHAFTTLRARGGALADMAIVVVDITEGFQPQTIEAIQILRNCKTPFVVAATKLDRIPGWRSTEKSPFLKSFAAQNERVTLLVETKVYDIVATLAEHGFSSERFDRVSDFARNLAIVPVSAHTGEGIPDLLMVLIGLAQRYMEEALTLTVDGPGSGTVLEVKEEKGLGATIDVILFDGTIRVGDEIAIATTEGVQTTKVRSLLQPRPMQEILVEDRFLRVKEVVAAAGVKVSAPGLDQVIAGSPVRVIGEDPEEVKTSIAKEMTEINVSLSPEGLIIKADTIGALEALCKELTAHEIPVMRAEVGQVSRHDVIEAETIKDPLYRVLIAFNTPVLPDAQDLLKEPAYAEMIQFFSGNVIYHILEDYLEWRNNLKRIMDQKRFEKIIFPAKILVLPGCVFRQNNPAVVGVRILSGTLRTGVNLVRRDGKKAGTLKSMQLRKENIQEAHAGDEVAISIEGATVGRQFDVEDELLVGIPERHVKVLETEMLSHLNEDAKEVLNEYTRLFRKENPFWGK
What is the function of this protein?
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes.  Seems to function along with eIF-2.
What are the official names of this protein?
Probable translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Protein: CAP2_VIBCH
Sequence: MKQELHHTLLGCGFRYTPAKQMPKGILLDTKSRRKGYYVKEYSTKGGVFVIALVLWNDPHIQLPFAYILQQPEQYKGRLLPHINFGFCLCYVTQMEADWNSNDLKSTYQDVDEQIQLTLDNSVASVESGTSNDVELEGEFSAYWQSEEELYLLAKPSRKAQLKAHLVEAELSSGSIRREYVAACSEQSEELVKWLNQRKFDESSLQEVSITTHCISVKPNRLAGVNWPPSCLREVLSWLKLVDYSAHARTVTLLMAKRTKRHILLFDVEGQDELAVYLELNLDVIGKRYFGRNAARKRNINNEAALLGGKFVSANFKRLGVTRADRDTLLSRNQSRPDVGNLSQKRIALIGCGTIGGYLAELLLRSGAGCGENYFHLYDNDSFKPHNFARHSLTAHNFGLAKSIALANSLKEAVHIAQSIKGIDRQFPIQADVLSKYDIVIDATGRPPVSKRLAAVARTLIADIRPVLIHAFNDGNGRASKVLVDDGRCCYGCMMADPAVYRNNIDLRFEGIDLAKEKHISCGSTYTPYDAAVSHITAALAQEAVLNTLEHTLPWNYSEHMLDGSRSKKPRTLKRFSGCNICDE
What is the function of this protein?
Protects E. coli against phage P1 and T2 infection.  When the 4 gene operon capV-dncV-cap2-cap3 is introduced in E. coli MG1655 there is about 100-fold protection against phages P1 and T2 (PubMed:31533127).  Protects E. coli against phage T2 infection.  When the CBASS operon (capV-dcnV-cap2-cap3) is introduced in E. coli MG1655 there is a more than 10(3) decrease in the efficiency of T2 plaque formation.  Protects 100-fold against phage T5, offers no protection against T7 (PubMed:32544385).
What are the official names of this protein?
CD-NTase-associated protein 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the HesA/MoeB/ThiF family.
Protein: ECTC_MYCVP
Sequence: MIVRTTDEITGTNRDVAAEHWRSKRIILADDGVGFSFHETTIDANSVSEFHYQHHVEAVWVVEGTGTLTNHETGEVHPLRPGTMYLLNGHERHRVTCDTTMRMLCVFNPPVTGREIHDENGAYPAAVQAS
What is the function of this protein?
Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.
What are the official names of this protein?
L-ectoine synthase, N-acetyldiaminobutyrate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the ectoine synthase family.
Protein: ZNUC_BACSU
Sequence: MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKSTLIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYTKGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLMLDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGGWKCLTWNSCDELF
What is the function of this protein?
Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable).  Responsible for energy coupling to the transport system (By similarity).  ZnuABC-mediated zinc transport is required for comF expression and competence development.
What are the official names of this protein?
High-affinity zinc uptake system ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS4_NEIMA
Sequence: MARYIGPKCKLARREGTDLFLKSARRSLDSKCKIDSAPGQHGAKKPRLSDYGLQLREKQKIRRIYGVLERQFRRYFAEADRRKGSTGELLLQLLESRLDNVVYRMGFGSTRAEARQLVSHKAIVVNGQVVNIPSFQVKAGDVVSVREKAKKQVRIQEALGLATQIGLPGWVSVDADKLEGVFKNMPDRSELTGDINEQLVVEFYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: MATK_PAETE
Sequence: MEKSQGYLELDKSWRHDFLYPLIFQEYIYALAHEQGLNRSILLENTDHDNKYSSLIVKRLITLIHQQNHFLIFDNDSNQNPFWKHNNNLYSQTISEGFVIIVEIPFSPRFVDSLEEKKKILKSNNLRSIHSIFPFLEDQILHLNFVANILIPYPIHLEIVVQSLRYRVKDASSLHLLRFFLFTLNKSISSFSKRNQRFFLFLYNSHVYEYESTFLFLRNKTSHLRSTSSGAFLERIFFYGKIKHLIEVFANDFQAILWLFKDPFMHYVRYQGKSILASKRTSLRMNKWKYYLVNFWQCQFYVWSQPGRVSINQLSNHSLDFLGYLSSVRRNPLAVRSQMLENSFLTDNAIKKFDIIVLLISLIGSLAKAKFCNVLGHPLSKPARADSSDSDIIERFVRICRNLSHYHSGSSKKKSLYRIKYILRLSCARTLARKHKTTVRSFLKRLGSELLEEFLTEDGQVISLIFPRTSSTSWRLYRGGIWYLDITCINDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MAK_MYCSS
Sequence: MNLPFDDWLPQQRWYGGRSREFSSATPDVVVTLRDDLDLVLLTVNYAEGRPEHYQILVRWDAAPIDEYSVVARIGSDTEHGERTGYDALYDPAAAHFLMTLIDSSAQVGDIRFAKEPEVTLPLQAAPRVSSAEQSNTSVIFDQDAILKVFRRITPGINPDIELNRVLARAGNPHVARLLGSFETTLDREPYALGMVTEFAANSAEGWDMALTSTRDLFAEGDLYADEVGGDFAGESHRLGEAVASVHSTLAAELGTSQVPFPLDTVLERLQSVADAVPELQPHAQSIEERYRKLADQEITVHRVHGDLHLGQVLRTTEGWLLIDFEGEPGQPLDERRRPDSPMRDVAGMLRSYEYAAYQRLIERGGDAQHDKQLAARAREWVNRNVSSFCDGYAAASGTDPRDHAELLAAYELDKAVYEVGYEARYRPSWLPIPMKSILRILGV
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate.  Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity).
What are the official names of this protein?
Maltokinase, MaK, Maltose-1-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the aminoglycoside phosphotransferase family.
Protein: KDSA_RICTY
Sequence: MKKVVKLNNIKIGNDLQFVLIAGPCQIEDEDHALFMAEKLIQLTSKLSIPFIYKSSFDKANRTSINGIRGLGIEKGLEILSKVKSEFNCPIITDVHSESQCTDTAKVVDILQIPAFLCRQTDLLKAAAKTGKIVKVKKGQFLAPWDMKNVQTKLEAFGAKDILFTERGSCFGYNNLISDMRSLAIMSELNVPVVFDATHSVQQPGGRGGSSGGERKYVELLAKAAISVGIAGIYMEVHQDPDNAPSDGPCMIKLDHLESILIKLKKYDKITKEE
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFOX3_HUMAN
Sequence: MAQPYPPAQYPPPPQNGIPAEYAPPPPHPTQDYSGQTPVPTEHGMTLYTPAQTHPEQPGSEASTQPIAGTQTVPQTDEAAQTDSQPLHPSDPTEKQQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFETSSDADRAREKLNGTIVEGRKIEVNNATARVMTNKKTGNPYTNGWKLNPVVGAVYGPEFYAVTGFPYPTTGTAVAYRGAHLRGRGRAVYNTFRAAPPPPPIPTYGAVVYQDGFYGAEIYGGYAAYRYAQPAAAAAAYSDSYGRVYAAADPYHHTIGPAATYSIGTM
What is the function of this protein?
Pre-mRNA alternative splicing regulator.  Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).
What are the official names of this protein?
RNA binding protein fox-1 homolog 3, Fox-1 homolog C, Neuronal nuclei antigen, NeuN antigen.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Largely restricted to neuronal nuclei. However, significant cytoplasmic localization in neurons from brains from HIV-infected individuals with cognitive impairment.
Protein: AMPA_BURCJ
Sequence: MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDMDGKRGKTLFLHEVSGIGASRVLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFSLAQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASHTLKRVVFSVDPADEKAAKVAVKQAVALANGMDLTRDLGNLPGNVCTPTYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGSFLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTIRAVAEMGLKINVVAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLFSTNDALAGELLDASREANDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGGAAKGATGRPVPLLAQFLIDRAGQ
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYV_SULTO
Sequence: MLSQEEINKKLEEWPKHYNPKEIELKWQQIWLSKEYWEKVFRFKDEDEKSPVFVIDTPPPFTSGELHMGHAYWVTIADTIGRFKRLQGYNVLLPQGWDTQGLPTELKVQYRLKIPKENRELFLKKCVEWTEDMIKKMKEAMIRLGYRPEWERYEYRTYENSYRKIIQKSLLEMYKLGLIEIREGPVYWCPKCETALAQSEVGYLEKDGILAYIRFPLKDGGEIIIATTRPELLAATQAVAVHPEDERYKGLIGKIAIIPLFNKEVKIIGDDAVEKEFGTGAVMISTYGDPQDIKWQLKYNLPTTELIDEKGRIKNTNGLLDGLKIEEARKKIIELLKEKGYLVKIENFKHNVLSHTERSDCLSPIEFLVKKQIFIKTLQFKDKLLEEYKKMKFIPSRMAYYLEDWIKSLEWDWNISRQRVYGTPLPFWYCDNNHLIPAREEDLPLDPTKTKPPYEKCPQCGLPLKPVTDVADVWIDSSVTVIYLTGFYTDKRKFEKTFPASVRLQGTDIIRTWLFYTFFRTLVLTGNIPFKEVLINGQVLGPDGTRMSKSKGNVVNPLDKVDEFGADSIRLTLLDARIGDDFPFKWETVRGKKLLLQKLWNAGRLSYPFIGKKKFDRPSNLHPIDRWILQEHKRFVKKSIEAYNNYDFYQVVESLYSYFWETIADEYLELIKHRLFAEDLSALYTLSRVFKDLLIILHPIAPHITEEMYNRLYGDKISIILEGLPNVDDIEEDPNIDTLGKYIKTTTSTIRTLKIQNRIPIPVSINVKLVGPKEYIETIKRVEDDIIKTLKIEKIVYEEGEEIKAELLS
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDB_TITME
Sequence: KVLAPAEEAPAEAPAAAE
What is the function of this protein?
Antimicrobial peptide (By similarity).  May also inhibit angiotensin-converting enzyme (ACE) and potentiate bradykinin (BK) (By similarity).
What are the official names of this protein?
Probable bradykinin-potentiating peptide, BPP, Probable antimicrobial peptide.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Long chain multifunctional peptide (group 2) family.
What are the subcellular locations of this protein?
Secreted.
Protein: 3BPI_HETMG
Sequence: GSICLEPKVVGPCKAGIRRFYFDSETGKCTLFLYGGCKGNGNNFETLHACRAICRA
What is the function of this protein?
Serine protease inhibitor.
What are the official names of this protein?
PI-stichotoxin-Hmg3b, PI-SHTX-Hmg3b, Kunitz-type serine protease inhibitor HMGS1.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
Protein: FAIM3_RAT
Sequence: MNLWLWLLYFLPVSGTLKVLPEVRLEVELGGSVFIECPLPQTHVRMYLCRQMTNPAICATVVSNIFVKKEYKRRVTLKPSLNKKLFLVEMTQLTKDDEGIYACGVGTNTDLGKTQKVTLNVRNEFPEYPEPFWDDEPTSEPSPRWWLHRYPEELPWLKMGEHASPSGFIDKVTTLSPKTEAPPVHQPSTNTSVSRHPRVYGASSETPTKPSALLPATTAFKTSARQASRLLEASYSHHTRLHGERTPHYGSQYGREDRGLHISIPEFHILIPTFLGFLLLVLLGLVVKRAIQRRRAFSRRVGRMARRMRGRGPSRQIPTQRRDAPQRPRSQNNVYSACPRRAREPDNVGSAEALLLNAPASAPPALPLVIETSWPHTPSLKMSCEYVSLGHQPAVNVEDQDSNDYINIPGLPHLPSKPPGPRPSRQ
What is the function of this protein?
May play a role in the immune system processes.  Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL.  Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream.  May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity).
What are the official names of this protein?
Fas apoptotic inhibitory molecule 3, IgM Fc fragment receptor, Regulator of Fas-induced apoptosis Toso.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: MSHC_MYCA1
Sequence: MAAGAGPGSAATMYVCGITPYDATHLGHAATYLAFDLIYRQWLDLGHDVHYVQNVTDVDDPLLERAARDGIDWRALAEREVSLFREDMAALRILAPRDYVGATEAIADVVELVEKMLASGAAYVVDGEFPDIYYRADATLQFGYESGYDRETMLRLFAERGGDPQRPGKTDALDALLWRAARPGEPSWPSPFGNGRPGWHVECAAIALSRIGSGLDIQGGGSDLIFPHHEFTAAHAECVRGERRFARHYVHAGMIGWDGHKMSKSRGNLVLVSQLRGRGVEPAAIRLGLLAGHFRGDRYWSDQVLDEATARLRRWRTATALPAGPDATDVIARVRQYLADDLNTPKALAALDGWTTDALDYGGHDTAAPRLVATAVDALLGVAL
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: NU4LM_OMMRO
Sequence: MTMVYANIFLAFITSLMGLLMYRSHLMSSLLCLEGMMLSLFVMMTITILNSHFTLASMTPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: THNL1_ARATH
Sequence: MEDKRVAMLVVMMLVMGNMLIEAEAVMSFKLCYGGCLVACALIAPPIKKLFCPFLCIKDCKRRPMLSFEANLNEIDQTGSYCELGCATDRCVSSSSIDDKGYYVNFSGIMWRKFHYAWIHAQKSAPTRTKIAIDFSL
What is the function of this protein?
May be involved in plant defense.
What are the official names of this protein?
Thionin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the plant thionin (TC 1.C.44) family.
What are the subcellular locations of this protein?
Secreted.
Protein: COBS_ECO8A
Sequence: MSKLFWAMLSFITRLPVPRRWSQGLDFEHYSRGIITFPLIGLLLGAISGLVFMVLQAWCGVPLAALFSVLVLALMTGGFHLDGLADTCDGVFSARSRDRMLEIMRDSRLGTHGGLALIFVVLAKILVLSELALRGEPILASLAAACAVSRGTAALLMYRHRYAREEGLGNVFIGKIDGRQTCVTLGLAAIFAAVLLPGMHGVAAMVVTMVAIFILGQLLKRTLGGQTGDTLGAAIELGELVFLLALL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KUP_ANASK
Sequence: MSQIPSPNDPASTGAAPSSAAVPAGPSATPAPSPTAGFSLPGHRPPPTGKALAALAVGALGVVYGDIGTSPLYSLKECFGGPHGVHPTDANVLGVLSLVFWAMTFVVTFKYMSFVMRADNRGEGGILALMALVGKTETTRLGRRMLLMLGLFGAALLYGDGIITPAISVLGAVEGVAVAAPAMERAVVPATVVILVFLFLFQKQGTAKVGAVFGPVMLVWFATIAVLGVRGILHDPTILRALLPTHGLSFFARNGWHGFLVLGGVVLVITGGEALYADMGHFGKRPIRVAWLGLAMPALLLNYLGQGALLLHDPGAARNPFYLLAPEWALYPTIAIATAAAIVASQALISGAYSLTQQAIQLGYSPRVTIRHTSQREIGQIYLPEVNWMLGTACLALVLGFQTSSRLASAYGIAVTGTMIVTTLLFHRVMRDRWGWARWKAWPLTSLFLTVDASFFLANVVKFRDGGWFPIAAAALVFTLMSTWKRGRDALALMLKDAGLPLDLFMADVARRKVQRVAGTAVFMTSNPGGVPPVLLHHLKHNKVLHERVVLVSILAHEIPFVNEPERVNARELGSGFFQVIAHYGFMETPDVPALLDSLPRRELAGPRITIVPMETTYFLGRETLLANGPSNIPTWRKRLFIVMARNAQTASAFFGLPPNRVVEMGAQIQL
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OCAT1_HUMAN
Sequence: MESVPGDYSKRVYQGVRVKHTVKDLLAEKRSGQTSNSRLNGSVSSSQSPFVQMPGSPVTSGYYGVRRSFLSDSDFHNSKQFSNDVYTSSVGKPFPCESSAGQSHAALLEPYFPQEPYGDYRPPALTPNAGSLFSASPLPPLLPPPFPGDPAHFLFRDSWEQTLPDGLSQPDPVSADALLTLPPSTSCLSQLESGSIAQHRGSSWGSSLAGAQSYSLHALEDLHHTPGYPTPPPYPFTPFMTVSNDLPPKVGPLSPDEEADTGSLHDPSPWVKEDGSIAWGSYECRRAY
What is the function of this protein?
Transcriptional coactivator of POU2F3 (PubMed:35576971, PubMed:36197978).  This complex drives the development of tuft cells, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971).
What are the official names of this protein?
POU domain class 2-associating factor 2, Oct coactivator from tuft cells 1, Protein OCA-T1, POU class 2 homeobox-associating factor 2.
What is the protein family that this protein belongs to?
Belongs to the POU2AF family.
Protein: DCTP1_POLSJ
Sequence: MTNRTPRISAIRSAALAALLAGLGMGAAQATEFRSADTHNADDYPTVAAVKYMGELLEKKSGGKHKIKVFNKQALGSEKETIDQVKIGALDFTRVNVGPMNAICPLTQVPTMPFLFSSIAHMRKSLDGPVGDEILKSCESAGFIGLAFYDSGARSIYAKKPIRTVADAKGLKIRVQQSDLWVALVSAMGANATPMPYGEVYTGLKTGLIDAAENNIPSFDTAKHVEAVKVYSKTEHSMAPEILVMSKIIYDKLPKAEQDMIRAAAKESVAFERQKWDEQEAKSLANVKAAGAEIVEVDKKSFQAVMGPVYDKFMTTPDMKRLVKAVQDTK
What is the function of this protein?
Solute-binding protein that binds D-galacturonate and D-glucuronate (in vitro) (PubMed:25540822).  Probably part of a tripartite ATP-independent periplasmic (TRAP) transport system that mediates solute transport into the cytoplasm.
What are the official names of this protein?
Solute-binding protein Bpro_3107.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 7 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL13_BUCAP
Sequence: MKTFSLKLNDIKRNWFYVDATNKILGRFASAISIRLRGKHKIEYTPHLDTGDYIIVLNASKILVTGQKKINKVYYHHTGYIGGIKQLRFEEIMLKNPAKVIEIAVKGMLPKGSLGRSMFKKLKVFSNENHDHIAQCPQFLNI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.