PharMolix/UniProtQA huggingface dataset:
Protein: IDI2_LISMF
Sequence: MQKNDDLLRERRKDEHVALGVKQNEQLAPSSLEDIQLIGTSIPRYNVKDIDLTTTIVGTNVPFPLYINAMTGGSRHTKKINAELAEIAREVAIPMAVGSQSAALKNSSLIDTYKIVREINPNGMILANISPEVALQEGLRAIEMLEANALQIHINPAQELVMQEGDRSFSHWLTRIEEYVKLSPVPVVVKEVGFGMTRETVKTLADIGVQTVDLAGKGGTNFAQIENDRRRDQAYDFLLDWGISTGQALIDMQHQDAPKIAYLASGGIRNPLDIVKALALGADSVGMAGQIIYSLKKEGVTKTIEKLELWKEQLRGLFVLANAKNISELKTTPLIISGELAKWGALREIDLVKLANRK
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAI2_ENCCU
Sequence: MANLVSVRRRPYRYPHSAIISSIFLIIIFTPDNLNNGATAFCSQLSPPYLDLQPIFSVLSASRQHHIPAFLLALACPIMGLIPMIKDSSTIPISRLPLLPSF
What are the official names of this protein?
UPF0328 protein ECU10_1820.
What is the protein family that this protein belongs to?
Belongs to the UPF0328 family.
Protein: UVRB_COXB2
Sequence: MSKAFKLTSKFKPSGDQPQAIEKLVAGLEDGLAYQTLLGVTGSGKTFTIANAIEKVQRPTLILEPNKTLAAQFYAEMREFFPENAVEYFVSYYDYYQPEAYVPSSDTYIEKDASINDHIEQMRLSATKAITERHDTIIIATVSAIYGLGDPDSYLKMLLHLTRGDQIDQRKILQRLAELQYTRNDLELRRATYRVNGDIIDIYPADSEREAVRVELFDDEVENLSYFDPLTGEMLRRVPRITVYPKTHYVTPREKLLSTLDQIKIELKERLSQLEKANKLVERQRLEQRTKFDMEMILELGYCSGIENYSRYLSGRNEGEPPPTLIDYLPKDALLIIDESHVTIPQLGGMYRGDRARKETLVEYGFRLPSALDNRPLRFDEFEKLAPQTIFISATPGPYEEKQSDQVVELLVRPTGLIDPEIEVRPVATQVDDLLSEIKKRAAQNERVLVTTLTKRMAEDLTEYFTEHNVRVRYLHSDIDTVERVEIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTMGRAARNVHGKAILYADRITDSMKRAMEEAERRRIAQSAYNEKHHITPKSIQKAVTEIIEGARTYTERGRFVNQAQLIAEEEAKYIAMTPKQLAKELRKLEEQMYHHARNLEFEEAAAVRDKIQHIRKGLLEVKE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_PSEPF
Sequence: MTSQRTRERLIQRLYEEGVSNASVLEVIRRTPRHLFVDEALAHRAYEDTALPIGNNQTISQPYMVARMSELLLEAGPLDKVLEIGTGSGYQTAVLSQLVERVFSVERIKVLQDRAKERLIELNLRNVVFRWGDGWEGWPALAPYNGIIVTAVATDVPQALLDQLAPGGRMVIPVGSGEVQQLMLIVREENGFSRHVLGAVRFVPLLNGPLA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLCM3_CAEEL
Sequence: MSRWKVVILCLLSFMFEIGHASFQCNPKTYDGAFLNIVCVCNATFCDEIEPIGEIAEGKAIVYRSSLDGDRLKRMSMKMKEKLRKNESVNVTITIDASERFQNIFGFGGAFTDSAGDQFVSLSETLQNYIVDSYFGKNGLEYNIGRVPIASCDFSTHEYSYDDVHDDFELKHFALPDEDLKLKIPFIKKAIEKTEGNIQLFASPWSAPGWMKVTGRMRGGGAMRNDKRVYQAYADYFFKFFEAYSSHAITFWGLTIQNEPSTGADMAWRWQTMNYTAETMRDFLKKYLGPKLKENKLTETLKVMVLDDGRGLLPGWADTIFNDPEATKYADGVAVHWYGNLYSPAVLLDITQRHHPTKFIFGTEACAGYFGHHGPIMGDWFRAESYADDIITDLNHHVTGWTDWNLCLDETGGPNWAYNVVDSPIIVNRTAQEFYKQPMFYALGHFSKFLPRGSTRVFTKIEGNLAVSATSVVIEGGRRATVILSKASNSLLTRIVDSSTGFSIVLNLPPRSIHTVIWKKRK
What are the official names of this protein?
Putative glucosylceramidase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 30 family.
Protein: ALT2_ARATH
Sequence: MFQATSTGAQIMHAAFPRSWRRGHVLPLRSAKIFKPLACLELRGSTGIGGFHEIELKVRDYELDQFGVVNNAVYANYCQHGRHEFMDSIGINCNEVSRSGGALAIPELTIKFLAPLRSGCRFVVKTRISGISLVRIYFEQFIFKLPNQEPILEAKGTAVWLDNKYRPTRVPSHVRSYFGHFQCQHLVD
What is the function of this protein?
Acyl-ACP thioesterase involved in the production of fatty acids and beta-keto fatty acids.  Can produce beta-keto fatty acids of medium chain (8:0 and 10:0) and small amounts of 8:0 fatty acid when expressed in a heterologous organism (E. coli).  May play a role in suberin biosynthesis.
What are the official names of this protein?
Acyl-acyl carrier protein thioesterase ATL2, chloroplastic, Acyl-ACP thioesterase ATL2, Acyl-lipid thioesterase 2.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PQIA_ECOLI
Sequence: MCEHHHAAKHILCSQCDMLVALPRLEHGQKAACPRCGTTLTVAWDAPRQRPTAYALAALFMLLLSNLFPFVNMNVAGVTSEITLLEIPGVLFSEDYASLGTFFLLFVQLVPAFCLITILLLVNRAELPVRLKEQLARVLFQLKTWGMAEIFLAGVLVSFVKLMAYGSIGVGSSFLPWCLFCVLQLRAFQCVDRRWLWDDIAPMPELRQPLKPGVTGIRQGLRSCSCCTAILPADEPVCPRCSTKGYVRRRNSLQWTLALLVTSIMLYLPANILPIMVTDLLGSKMPSTILAGVILLWSEGSYPVAAVIFLASIMVPTLKMIAIAWLCWDAKGHGKRDSERMHLIYEVVEFVGRWSMIDVFVIAVLSALVRMGGLMSIYPAMGALMFALVVIMTMFSAMTFDPRLSWDRQPESEHEES
What is the function of this protein?
Component of a transport pathway that contributes to membrane integrity.
What are the official names of this protein?
Intermembrane transport protein PqiA, Paraquat-inducible protein A.
What is the protein family that this protein belongs to?
Belongs to the PqiA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RBL_CORKO
Sequence: SVGFKAGVKEYKLTYYTPTYETKDTDILAAFRVTPQPGVPPEEAGAAVAXESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEENQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPPHXIQVERDKLNKYGRPLLXCTIKPKLGLSAKNYGRAVYECPRGXXDFTKDDENVNSQPFMRWRDRFLFCAEAXYEAQTETGEIKGHYLNATAGTNEEMMKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDGFIEKDRSRGIYFTQDWVXLPGVLPVASGGIHVXHMPALTEIFGDDSVLQFGGGTLGHPWXXRPGAVANRVALEACVQARNEGRDLAXEGNEIIREASKWSPELAAACEVWKEIKFEFEAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NADD_ALIB4
Sequence: MKIAIFGGSFDPIHIAHKAIVKRALEELEIDKLIIVPTYLNPFKSSFYLEPKVRFELLKKVFEKVEKVEISDYEINQEKLSYSFNTVNYLKDLYKASKIYFILGQDNVENLDKWYKIEELKKMVEFVIATRSGYKSDKLKDFRTLNIDIDVSSTLLRTQIDTKYIPKEIKEDILNLDKGKKN
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: CLPX_PHOPR
Sequence: MTDKRKDTGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVMPKRDGNDLPTPQEIRTNLDDYVIGQNHAKKVLAVAVYNHYKRLRNGDTTSDGVELGKSNILLIGPTGSGKTLLAETLARMLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVAKAERGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVVEQRVATGTGIGFSADVRSKSEERTISDLFKKVEPEDLVKYGLIPEFIGRLPVTATLTELDQEALVKILREPKNALTKQYAALLELENVELEFRDDALVAIAHKAMARKTGARGLRSIVEAVLLDTMYELPSAVGVSKVVIDESVINGESEPLLIYENTENQAAGAE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: HRI1_KLULA
Sequence: MVSLTKRVLFEVIPNPPDETTLTLSSTTNKGHYISVRPFVNAEGKEFPFEWAFGGTSDHIELKKINERANSLNFNFKFDTNVKLNVPETHRGVIKTVFKTWDSGLVEETGSVFPWGTEGTEVKFRELWQPVDPTRLEFVELNNEKDVDQAANSIALSVDNEEYEGLVIVVGRWIQGILFKKGVNTLDGINLFRSQIDEKNSIVSLVKFGADADKFPQEVLLNEGSITTSKGLEWSVIESNL
What are the official names of this protein?
Protein HRI1.
What is the protein family that this protein belongs to?
Belongs to the HRI1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS11_MYCBO
Sequence: MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENAARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPNRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: LPTD_SHEON
Sequence: MQIRYLLALSLLPKLVLADESPATSASQCLIEPPVPRIVSQPGLSAADQAKIRIASDRSKAEMGKQAIFTGDVVFSQGDRHIAADEAILDQATEQFDANGNLVFQDSNFTVTADSLQAQMRSNRATLTGAQYWLHGQQVHGDAEKLQITINNNLILTNTNFTTCPPDNVSWLLEAEKIKINSEEEWGEIWNAKLRVADIPVFYIPYMTVPVSDKRKTGFLYPSFSTSTTNGFEVSAPYYWNIAPEYDLTFTPNYMTNRGLFTKTEFRYLAGEAQNGRLNLEYLGSDQMLNGSPNRYLYNWQHQGAIDKNWRVLANFTEVSDNNYFNDLKSDVNRATDNQLSRIGEVSYFERDWDISTRVQDIKVLGEDEKPYQVMPQVNFNYRAADFWNNLDFGFNSELTNFAHQDDDVNTATRLHMAPSLTLPIHGPSGSFTSQLKLMQTNYWQEKNNSKFDSLDDTVSRTIPQVRINGQINFERFTELFEHNYRQTLEPQFQYLYVGYEDQRGIGIYDTAQLQDDYFGLFRDRRFSGLDRIADANQVTLGITTRLFDDHNQEATKFSLGQIFYLQDSKLGYEDNIFEQNQSTSVLAAELDTRLSSNWYLGAAIQYDTNTSDNKKTEVTLDFRPEANKLLQFSYRYVPDLLNSNTNDLVNISQAGVRGAWPINDSLYFVGNWYYDLNETRSIETYTGVQYESCCYAIRLSYHYRIKTNYDDNIGSTIIDEREQFESGVYLNLIIKGLGGSGPLGVSDMLNDGLFNYRKPLYLRN
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: HOLA_ECOLI
Sequence: MIRLYPEQLRAQLNEGLRAAYLLLGNDPLLLQESQDAVRQVAAAQGFEEHHTFSIDPNTDWNAIFSLCQAMSLFASRQTLLLLLPENGPNAAINEQLLTLTGLLHDDLLLIVRGNKLSKAQENAAWFTALANRSVQVTCQTPEQAQLPRWVAARAKQLNLELDDAANQVLCYCYEGNLLALAQALERLSLLWPDGKLTLPRVEQAVNDAAHFTPFHWVDALLMGKSKRALHILQQLRLEGSEPVILLRTLQRELLLLVNLKRQSAHTPLRALFDKHRVWQNRRGMMGEALNRLSQTQLRQAVQLLTRTELTLKQDYGQSVWAELEGLSLLLCHKPLADVFIDG
What is the function of this protein?
Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex (PubMed:2040637).  DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3'-5' exonuclease activity.  The delta subunit is the wrench that will open the beta subunit dimer, which has been modeled to leave a gap large enough for ssDNA to pass through (PubMed:11525728).  The gamma complex (gamma(3),delta,delta') is thought to load beta dimers onto DNA by binding ATP which alters the complex's conformation so it can bind beta sliding clamp dimers and open them at one interface.  Primed DNA is recognized, ATP is hydrolyzed releasing the gamma complex and closing the beta sliding clamp ring around the primed DNA (PubMed:9927437).
What are the official names of this protein?
DNA polymerase III subunit delta.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase HolA subunit family.
Protein: UVRB_YERPA
Sequence: MSKSFKLHSVFKPAGDQPEAIRKLEEGLENGLAHQTLLGVTGSGKTFTVANVIADLNRPTMILAPNKTLAAQLYGEMKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGVPDLYLKMMLHLTRGMIIDQRSILRRLSELQYSRNDQVFQRGTFRVRGEVIDIFPAESDEWALRVELFDEEVERLSIFDPLTGQLQHEVPRFTVYPKTHYVTPRERILQAMEEIKVELAERRQVLLANNKLLEEQRLSQRTQFDLEMMNELGYCSGIENYSRYLSGRGPGEAPPTLFDYLPADGLLIVDESHVTIPQIGGMYKGDRSRKETLVEYGFRLPSALDNRPMRFEEFEALAPQTIYVSATPGKYELEKSGGDIIEQVVRPTGLLDPLIEVRPVATQVDDLLSEIRIRAAINERVLVTTLTKRMAEDLTDYLSEHGAKVRYLHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYGDRITASMEKAIGETERRRAKQQAYNEERRIIPQGLNKKIGDILQLGQPSMRGKGKGRGSHKMADTTQYQSLSPKALDQKIRELEAKMYTYAQNLEFEQAAELRDQVHQLRQQFIAIS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLP2_DROME
Sequence: MVKIEEGLPSSEISAHSLHFQHHHHPLPPTTHHSALQSPHPVGLNLTNLMKMARTPHLKSSFSINSILPETVEHHDEDEEEDVEKKSPAKFPPNHNNNNLNTTNWGSPEDHEAESDPESDLDVTSMSPAPVANPNESDPDEVDEEFVEEDIECDGETTDGDAENKSNDGKPVKDKKGNEKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTTAASRSRLAAFKRSLIGPMFPGLAAYPQFGQFLTYPPTAPSLLASMYQRYNPFAPKGGPGHPGLPPGLPGLPGPPGPQGPPGPPPPPFVAPPTSSELYQRLQYQQLLHQHAAAAALAAHQRQLSVAAASAASQPPPTHHHPHLAVGQAPLSPGGDSPGPSPQPLHKPVTVVSRNS
What is the function of this protein?
Transcription factor involved in segmentation.  May function primarily as a segment polarity gene.  Different levels of slp activity seem to be required in different segments.
What are the official names of this protein?
Fork head domain transcription factor slp2, Sloppy paired locus protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVB_GEOTN
Sequence: MDERLVSGSALGGEAAFEPTLRPQYLHEYIGQDKVKENLQVFIEAAKLREETLDHVLLYGPPGLGKTTLAAIIANEMGVKMRATSGPALERPGDLAALLTSLEPGDVLFIDEIHRLPRTVEEVLYPAMEDYCLDITVGKGPEARSLRLDLPPFTLVGATTRAGALSAPLRDRFGVISRLEYYQVDQLAQIIERAAAILHIIINNEAALELARRARGTPRIANRLLRRVRDFAQVRGDGEITLPLAVEALERLQVDRLGLDHIDHKLLLAIIEKFAGGPVGLETMAAVIGEEAQTIEEVYEPYLLQIGLLQRTPRGRVATPAAYAHLGMEVPKR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: HLDE_KORVE
Sequence: MSTNVADLLHTIKNNWCDRSILVVGDVMLDQYIWGDVGRISPEAPVPIVRATHRTEQPGGAANVALNIARLGARATIVGFTGTDDNERALKDYLSSNRVEADFVSCEGFPTITKLRILSGRQQMLRLDNERAESRPSTAYQKLIERALHHLPQSDALILSDYAKGVLLPEVCQTLIQAAAQRKIPVLVDPKNVDFSRYRGATTISPNLGELALAARVDLENLNDLLYAAQQMVRNLGLSFLTATLGEKGIALVTRDKTTISAAVARQVFDVSGAGDAVIATLSLSLASGLDPELGVHLANLAGAIVVSKVGTAPVEQYELLNALTAESVPVAQAKVVTRSELLELVARWRRNDERIVVTNGCFDLLHVGHISLLEQARGFGDRLVVAINSDRSVRELKGNSRPIVGEQERARVLAAIAAVDAVVIFDERTPLELIEATRPDVLVKGGDYAVSGVVGAEEVQSWGGHVKIVPIVEGFSTTKLIEKGH
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: GRAB_RAT
Sequence: MKLLLLLLSFSLAPKTEAGEIIGGHEAKPHSRPYMAYLQIMDEYSGSKKCGGFLIREDFVLTAAHCSGSKINVTLGAHNIKEQEKMQQIIPVVKIIPHPAYNSKTISNDIMLLKLKSKAKRSSAVKPLNLPRRNVKVKPGDVCYVAGWGKLGPMGKYSDTLQEVELTVQEDQKCESYLKNYFDKANEICAGDPKIKRASFRGDSGGPLVCKKVAAGIVSYGQNDGSTPRAFTKVSTFLSWIKKTMKKS
What is the function of this protein?
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (By similarity).  It cleaves after Asp (PubMed:9765264).  Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (By similarity).  Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution (By similarity).  Cleaves caspase-3 and -9 (CASP3 and CASP9, respectively) to give rise to active enzymes mediating apoptosis (PubMed:9765264).  Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity).
What are the official names of this protein?
Granzyme B, Fragmentin, Natural killer cell protease 1, RNKP-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Granzyme subfamily.
What are the subcellular locations of this protein?
Secreted. Cytolytic granule. Note=Delivered into the target cell by perforin.
Protein: SPC1_SCHPO
Sequence: MNYLEGTIDFAGQLRCQKYMNYGLCTSAVISYIYGYLVQDSYCVIKLFLILASLVALVCLPAWSMYNKNPLKFQKKKE
What is the function of this protein?
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.  Dispensable for SPC enzymatic activity.
What are the official names of this protein?
Signal peptidase complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the SPCS1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RHO3_ASHGO
Sequence: MPLCGSSSSSKHPIERKIVILGDGACGKTSLLNVFTRGYFPKVYEPTVFENYIHDIFVDNQHITLSLWDTAGQEEFDRLRSLSYSDTHTIMLCFSVDSRDSLENVKNKWVSEIADHCEGVKLVLVALKCDLRSSDEYGNESAITPGSIQNQKYNGGGGNGLIPYDEGLAMAKQIGALRYLECSAKMNRGVNEAFTEAARCALTATPKGARDSAPEAESSSCTIM
What is the function of this protein?
Involved in the regulation of actin polarization.  Rho proteins are required for distinct steps during polarized hyphal growth of A. gossypii.
What are the official names of this protein?
GTP-binding protein RHO3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: FNR_ECOLI
Sequence: MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGSGHHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENNDALAQLAGHTRNVA
What is the function of this protein?
Global transcription factor that controls the expression of over 100 target genes in response to anoxia.  It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism.  When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration.
What are the official names of this protein?
Fumarate and nitrate reduction regulatory protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPNP_PSEAB
Sequence: MFKVNEYFDGTVKSIAFDMTAGPATIGVMAAGEYEFGTSQLEIMHVVAGALTVKLPGSDEWQEYASGSQFTVPANSKFQLKVAQDTAYLCEYR
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: FUCI_SALSV
Sequence: MKKISLPKIGIRPVIDGRRMGVRESLEEQTMNMAKATAALITEKIRHACGAQVECVIADTCIAGMAESAACEEKFSSQNVGVTITVTPCWCYGSETIDMDPMRPKAIWGFNGTERPGAVYLAAALAAHSQKGIPAFSIYGHDVQDADDTSIPADVEEKLLRFARAGLAVASMKGKSYLSVGGVSMGIAGSIVDHNFFESWLGMKVQAVDMTELRRRIDQKIYDEAELEMALAWADKNFRYGEDQNASQYKRNEAQNRAVLKESLLMAMCIRDMMQGNKTLADKGLVEESLGYNAIAAGFQGQRHWTDQYPNGDTAEALLNSSFDWNGIREPFVVATENDSLNGVAMLFGHQLTGTAQIFADVRTYWSPEAVERVTGQALSGLAEHGIIHLINSGSAALDGACKQRDSEGKPTMKPHWEISQQEADACLAATEWCPAIHEYFRGGGYSSRFLTEGGVPFTMTRVNIIKGLGPVLQIAEGWSVELPKAMHDQLDARTNSTWPTTWFAPRLTGKGPFTDVYSVMANWGANHGVLTIGHVGADFITLAAMLRIPVCMHNVEEAKIYRPSAWAAHGMDIEGQDYRACQNYGPLYKR
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
What are the official names of this protein?
L-fucose isomerase, 6-deoxy-L-galactose isomerase, FucIase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.