Protein: GCN1_DICDI
Sequence: MNEENPSSSIILDDQQQQDSFYSEIKELEKSIQSNKLSERKNTLTRINSIGKHELSTQENDATTTTTTTTVDLEEKLKVLIYLYFTSYSIGPDSQWIFSLVQSLKQLFKDISSATNTSLVTDELKINIVKFTLREIGRLAKLLPTNKRSKYVPQNTLMSFSLVLLNYFIDQIQSNSDLTTLLFAAQELLYRELTLQHMKNNQPIFNQILNKNKILTFYQNIVTKDSSNKSFFIVYFLLRNFTDQSNKQKEQDNTFKINDLLNIYNKTVIGSSQQKIEEHKFFKRLFNQLTNEDLQSIILPPLSRHIKRDQDQVFKILIFILENLSSDFNVIDLSSLLKSMLLPMLLPVIQSTISIEENRKLLKKTFTLIIERSKDTKLISSMITDDLLKTLSVAGNPSQKLIIISIISSIISTKNFIERLSLTTEKLQLSKQILQSISIYLEKELNKDNRNKGFKLLGKVMKMVEELPEQTIKIITNSLKNDDDIIKGQVILSLSKSLGPEANGTNKKVIQIINGFTETINTILKNVKNAKTCDPSTTTASLHYMLSLITTTGVPKNDIFTKYSTDKTTISNLYASTSFLHTDGFIQRTSKKDHAIDLLLTLFLRVKSFPSIKLNDKSPLYSSVLNCLLHSQWSVSKHSAIKIRSILSRNDSVDIDYPLLSNQLLIEFSTILFDDSLIITPQIINSNVESTTTTTTTISNKKNYLIAFRSILSKNIKSELYPMLSLICYHPFINYNWKRVSSLIQNDVNTTLSSNAIEISKYIFEKGLNQKKNKSYQQAFQQAINGLMNYNVPLLNEELVKLMVKALSYEPVLAITQQQWSIYHTLPTELFVEKQEQLVESRNDRKVKPKTAEEQRDEESRKRIEEKKKIQSGELEKQEKERQKQLAAQAVIRKDVQDVIDRLHLAMDTCQTMAKSSSNPQFVGEFMSPIIVALLQLMKHEITNHQFTQVFEKLICCVPSRFKLDRSFARHYIYIINNIYYRPTLSEIQILGFIQKILTHIRESIAKEALSGFAFNYFWPIIKNGLETTISFTIQEISMEIIQKHTAQGQAYPRGSMISSLIIVVSTNSRLEAQARNTIFQLIEGVETSDIGELMEGIISKHVQVRSICLQAIEKIPSIYSPSFVWEDKYIGSLWFARFDNHDANTSALAEKIWLATNQPTQLPEDFMKLLSDSTFNVNSETRKINALAIKEAATCHTHMIPEIVDNLFEIYEQNYPDEIRETPITSKFRISVATALSGLGNAIVEPEVLKSLFTKIIERGLFDPKEEVVQEFVSTGMSIINQQGVQFSGELLATFEAFLARPDNGTGEEDSIRANVVVYMGALAKHMDASNPKVSIVIDKLVDALSIPSESVQVGISKCIAQLIPSFKKQGDRLIPMLLEKLKNSSGNYADRRGAAFGLAGSVKGLGIGSLKNYSILDTLQSYIEDKKHPTSRQGALFAFECLCNTIGRVFEPYIIHILPKLLVCFGDNVSEVRDATADTAKAIMSQLSGHGVKIVLPALLKALDDRSWRTKEGSIELLGAMAFCAPKQLSSCLPTIVPKLTYVLNDTHTKVQEAAKEALSHIGSVIRNPEIQIHVPLLLQTYDDPEIHSKELLENLLSTNYVHTIDPASLSLLLPILERTLKERSSELKKMSCQIVGNLCSLTEPKDLVPYLNILMPVMKTVLLDPIPEVRAICARALGLLVRGMGEENFSTLIPWLLETVKSDQGAVERSGAAQGLSEVLASLDISRFNSLINELLAMTNSPRPHVREGILSIFIFTPISLGDLFLPYLPKVLPQVLKGLADDSDPVREVCMRCGQSIVLQFAVTGIEVIVPALEKVLFHENWRIRLSCVQLFGDLLFKLAGTTAQEVQSNNSSYNAKDDDDDEPGSSGNDIQKILGKERLGRILSSLYMMRFDNNSSVRQKVLLIWKYIVSNTPKTLREILPTLIEMIISSIGSNNVEKRQISAKTLGDIVSKLSDRILPEILPILERGLRSELEETRQGVCIGLSEVISSAKTQLLPYLSSVVTCITKALCDPLIDVREAAAKAFDHLYHTFGSKASNEILPQLIQLLDNSNNKDLAGYALDGLRQVILVRSSIVLPVLIPKLLSRPISTSNVTALSSLAADAGEGLYVHLSTIIPSLIESFTNPNTISNAKEIKEAAVSICKSIDEQGWDTLIGLLIEQTEIRLPNIRLGACELIGEFYNGNTMVTEYPEELLLSLLSLFNDPDALVQQAANNALGFITKSLKKDNLTYLPVFQKGIQLLVNETYEEVSTIPGFCLPKGLASVLPVLISGLMYGTSDQREQATNTLRTVINHTSADALKPFVMQITGPLILVIGDKFPWQVKSAILQTLSLLISKSPASMKIFLHQLQPTFIKCLSDSHKNVRTNAASALGLLMTLSSSVDQLVNSLITGISTADSISQESKLRALQSIFEKKPKVEQATLDKAIATIVDFLYQPSDDLRSMVAQTIGASSKCFTSLTELNQFIKTNLISPSQSVLSRYGKSLALGEIFKASGKNLIDSQSPNMPTIIKIIQTDCRDEKGPIRESSAYLAEAILVASPLTYAKDLVPSICHLIGDQSSSVSISALNVIKRFCKSNQQLSRQYLRDIVVPTMNRLKERTNLPLKLAAERTLVHSLQIFKESIVMDDLIKQLELSGDSSMANSLIDYHKRVLMKLSPDSDIEK
What is the function of this protein?
Acts as a positive activator of the gcn2 protein kinase activity in response to amino acid starvation.  Forms a complex with eif2ak4/gcn2 on translating ribosomes; during this process, gcn1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of eif2ak4/gcn2, and hence stimulating eif2ak4/gcn2 kinase activity.  Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator atf4, by promoting the eif2ak4/gcn2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/eif2s1) on 'Ser-53', and hence allowing atf4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.
What are the official names of this protein?
eIF-2-alpha kinase activator GCN1, GCN1-like protein 1, Translational activator gcn1.
What is the protein family that this protein belongs to?
Belongs to the GCN1 family.
What are the subcellular locations of this protein?
Cytoplasm.