PharMolix/UniProtQA huggingface dataset:
Protein: PRHI_PENBI
Sequence: MYNIQDHVVIITGSSSGIGLAASTLALASGAKVFGIDISNSPTSVTANPNYTFFAADLSHPESAKKAIAACIAAYGNRIDGLLNIAGVMDLNQSADTVTDDMWDRCIAINLTAPVKLMREVIPIMRLRGKGSIVNVGSKASMSGAVSGIAYTASKHGLVGATKNVAWRFKHEGIRCNIVCPGGVAATGIRDGVDSTQFDSEALEMMSVIHQAHASDHAKGLGLQPEDLAHSLLYFLSDLSKGISGAVIPVDNAWSTI
What is the function of this protein?
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture (PubMed:27602587).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase prhL (By similarity).  Synthesis of DMOA is followed by farnesylation by the prenyltransferase prhE, methylesterification by the methyl-transferase prhM, epoxidation of the prenyl chain by the flavin-dependent monooxygenase prhF, and cyclization of the farnesyl moiety by the terpene cyclase prhH, to yield the tetracyclic intermediate, protoaustinoid A (By similarity).  The short chain dehydrogenase prhI then oxidizes the C-3 alcohol group of the terpene cyclase product to transform protoaustinoid A into protoaustinoid B (PubMed:27602587).  The FAD-binding monooxygenase prhJ catalyzes the oxidation of protoaustinoid B into preaustinoid A which is further oxidized into preaustinoid A1 by FAD-binding monooxygenase phrK (PubMed:27602587).  Finally, prhA leads to berkeleydione via the berkeleyone B intermediate (PubMed:27602587, PubMed:29317628).  PrhA is a multifunctional dioxygenase that first desaturates at C5-C6 to form berkeleyone B, followed by rearrangement of the A/B-ring to form the cycloheptadiene moiety in berkeleydione (PubMed:27602587, PubMed:29317628).  Berkeleydione serves as the key intermediate for the biosynthesis of paraherquonin as well as many other meroterpenoids (Probable).  The cytochrome P450 monooxygenases prhB, prhD, and prhN, as well as the isomerase prhC, are probably involved in the late stage of paraherquonin biosynthesis, after the production of berkeleydione (Probable).  Especially prhC might be a multifunctional enzyme that catalyzes the D-ring expansion via intramolecular methoxy rearrangement, as well as the hydrolysis of the expanded D-ring (Probable).
What are the official names of this protein?
Short chain dehydrogenase prhI, Paraherquonin biosynthesis cluster protein I.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SPEE_PECCP
Sequence: MSQKEIWYETLHANFGQYFSVDRVLYHEKTDHQDLIIFENDALGRVMALDGVVQTTERDEFIYHEMLTHVPLLSHGNAKRVLIIGGGDGGMLREVSRHHGVEHITMVEIDAGVVEFCRQYLPNHSAGSYDDPRFNLVIDDGVNFVRQCSDKFDVIISDCTDPIGPGESLFTSDFYQGCARCLNEGGIFVAQNGVCFLQQDEAVGSHKKLGHYFKDVSFYQAAIPTYYGGIMTFAWASNNPALRQIDATTLRQRFAQSGITCRYYTPDVHIGSFALPQYLLSALQNAQ
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C71A2_SOLME
Sequence: MDVPCPWYSLLIPLFVFIFLLIHHCFFTTSKKQNMLLLPSPRKLPIIGNLHQLGSLPHRSLHKLSQKYGPVMLLHFGSKPVIVASSVDAARDIMKTHDVVWASRPKSSIVDRLSYGSKDVGFSPFGEYWRRAKSITVLHLLSNTRVQSYRNVRAEETANMIGKIRQGCDSSVINLGEHLCSLTNNIISRVALGRTYDEKESGIEHIIEQFVELLGIFNVGDYIPRLEWVNKFTGLDAKVKKVAKELDMFLEIVIEEHIIRKKKEEYTSTGEAKDFVDVLLEIQNGNETDFPLQRDSLKAILLDSFAAGTDTTFATLDWTMAELLRQPRALKTLQDEVRGLAQGKSEITEDDLKNMQYLRAVIKESLRLHPTQESLLVPRESMEDVNLLGYYHIPARTQAIINAWAIGRDPLSWENPEEYQPERFLNSDADVKGLNFKLLPFGAGRRGCPGSSFAIAVIELALARLVHKFDFALPEGIKPEDLDMTETIGITTRRKLPLLVVATPC
What is the function of this protein?
May have a role in maturation, such as during flavor formation or other metabolite production specific to aging tissues.
What are the official names of this protein?
Cytochrome P450 71A2, CYPLXXIA2, Cytochrome P-450EG4.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane. Membrane; Single-pass membrane protein.
Protein: TSEAR_HUMAN
Sequence: MSALLSLCFVLPLAAPGHGTQGWEPCTDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTVGCRDWEAFSTTAGAYLIYSSAKEPLSRVLRLRTR
What is the function of this protein?
Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway (PubMed:27736875).  May play a role in development or function of the auditory system (PubMed:22678063).
What are the official names of this protein?
Thrombospondin-type laminin G domain and EAR repeat-containing protein, TSP-EAR.
What are the subcellular locations of this protein?
Secreted. Cell surface. Cell projection, stereocilium. Note=Secreted protein which may bind to the cell surface via a membrane receptor.
Protein: FBSB_TRIV2
Sequence: MENTLGLEIIEVVEQAAIASAKWMGKGEKNTADQVAVEAMRERMNKIYMRGRIVIGEGERDDAPMLYIGEEVGICTQPNADQLCNPDELVEIDIAVDPCEGTNLVAYGQPGSMAVLAISEKGGLFAAPDFYMKKLAAPPAAKGKVDINKSATENLKILSECLDRAIDELVVVVMKRDRHQGLIKEIRDAGARVQLISDGDVGAAISCGFAGTNIHALMGIGAAPEGVISAAAMRALGGHFQGQLIYDPEVVKTGLIGESKEANLERLSSMGINDPDKVYDAHELASGETVLFAACGITSGNLMQGVRFFHGGARTQSLVISSQSQTARFVDTIHMAGQPKTVQLH
What is the function of this protein?
Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6-phosphate and sedoheptulose 7-phosphate, respectively.
What are the official names of this protein?
D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase, FBPase class 2/SBPase.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 2 family.
Protein: MTSA_STRPN
Sequence: MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIADITKNIAGDKIDLHSIVPIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTKLVENAKKTENKDYFAVSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNIAKQLSAKDPNNKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVPSAYIWEINTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQIFTDSIAEQGKEGDSYYSMMKYNLDKIAEGLAK
What is the function of this protein?
Part of an ATP-driven transport system for manganese.  Also acts as an adhesin which is involved on adherence to extracellular matrix.  It is an important factor in pathogenesis and infection.
What are the official names of this protein?
Manganese ABC transporter substrate-binding lipoprotein, Pneumococcal surface adhesin A.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RL23_CAEEL
Sequence: MSKRGRGGASGAKFRISLGLPVGAVMNCADNTGAKNLFVISVYGIRGRLNRLPSAGVGDMFVCSVKKGKPELRKKVLQGVVIRQRKQFRRKDGTFIYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIAANAGSIA
What are the official names of this protein?
60S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: COQ8A_BOVIN
Sequence: MAAMLGDAIMLIKGFVKLTQAAVETHLQHLGLSGELLMAVRALQSTATEQVGMVFGQVQGQETPEEYYSESLDDPEGAFHFSGMRAESASADVSAASSPEQSPPPWAHAAGSEGPAPAYVASAPFREGGVLGQAASPLGRVNGRLFASPRDPFSAPGLQRRVYHQDQSSMGGLTAEDIEKARQAKARPESKPHKQALSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRPDDPSGKKAVLDSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFDRVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARLKGGREVAMKIQYPGVAQSINSDVNNLMTVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARRFRELLKDHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFQFMQTDPNWSNFFYDPELHKVALLDFGATREFDRSFTDLYIQIIRAAANQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEAFASEEPFDFGTQSTTEKIHNLIPIMLKHRLVPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCRRQAEQQ
What is the function of this protein?
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.  Its substrate specificity is unclear: does not show any protein kinase activity.  Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates.  Shows an unusual selectivity for binding ADP over ATP.
What are the official names of this protein?
Atypical kinase COQ8A, mitochondrial, Chaperone activity of bc1 complex-like, Chaperone-ABC1-like, Coenzyme Q protein 8A, aarF domain-containing protein kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. ADCK protein kinase family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single-pass membrane protein.
Protein: BL1S4_YEAS2
Sequence: MQDNSSHSRESASAGDDPLGIDKLTVDYDYLLYKIRDYVQSIQLDTTELCKKQNEVMVNGIIENTIDKNIAKFKELLEKCDTLENHYEMLNQLAIITDTFKERIAEAVNNYNSLKKGASKSK
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit CNL1, BLOC-1 subunit CNL1, CNO-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S4 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Punctate pattern.
Protein: RS13_NOSS1
Sequence: MARIAGVDLPRDKRVEIGLTYIYGIGLSRSQEIIAATGVNPDTRVKDLSDADVAALRGEVESNYQVEGDLRRLEAMNIKRLVDIGTYRGRRHRMGLPVRGQRTRTNARTRRGRRQTVAGKKKAPGK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: BIOF_YERE8
Sequence: MSWQNKIDLGLQQRHEAAAYRCRQVNDGANGRWLQTGAQQYLNFSSNDYLGLSQDAAVIAAWQQGAQRYGVGSGGSGHVTGYSLPHAQLEQQLADWLGYPRALLFISGFAANQAVLTALTAADDRILADKLSHASLLEAATHSPAQLRRFAHNQPDSLQKLLNKPCSGQTLVVTEGVFSMDGDSAPLAAIQQHTAAAGGWLLVDDAHGLGVRGAAGRGSCELQGVKPELLVVTFSKAFGLSGAAVLCQEPVAEYLLQYARHLIYSTAMPPAQACALQAALLRIQQGDDLRQRLQQRITQFRCGAAALPLQLGASETAIQPLLVGDNQQTVALAEQLRAAGLWVTAIRPPTVPPGGARLRITLSAAHESEDIDRLLEVLHGVCH
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: CRD1_CHLRE
Sequence: MQTTLKQQRASGRVSARQPFRSAAVARPRRSTVRVQASAAPLNDGLGFETMRDGIKVAAKETLLTPRFYTTDFDEMEQLFSKEINPNLDMEELNACLNEFRNDYNKVHFVRNETFKAAADKVTGETRRIFIEFLERSCTAEFSGFLLYKELARRMKASSPEVAEMFLLMSRDEARHAGFLNKALSDFNLALDLGFLTKNRTYTYFKPKFIIYATFLSEKIGYWRYITIYRHLQRNPDNQFYPLFEYFENWCQDENRHGDFLAACLKAKPELLNTFEAKLWSKFFCLSVYITMYLNDHQRTKFYESLGLNTRQFNQHVIIETNRATERLFPVVPDVEDPRFFEILNKMVDVNAKLVELSASSSPLAGLQKLPLLERMASYCLQLLFFKEKDVGSVDIAGSGASRNLAY
What is the function of this protein?
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis under oxygen- and copper-deficient conditions.  Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).
What are the official names of this protein?
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1, chloroplastic, Mg-protoporphyrin IX monomethyl ester oxidative cyclase 1, Copper response defect 1 protein, Copper-response target 1 protein.
What is the protein family that this protein belongs to?
Belongs to the AcsF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane.
Protein: PYRB_FRACC
Sequence: MGSTSRVRGTGVNRHLLSTEDLDRDDALLVLDTAERMARVAEASVRKLPTLRGRTVVNLFFEDSTRTRTSFEVAAKRLSADVINFSARGSSVSKGESLKDTAQTLEAMGADAVVCRHAASGAPHRLASWVRGSVVNAGDGTHEHPTQALLDAFTMRRRLGRIDGLAVTIVGDVLHSRVARSNVWLLATLGATVTVVAPPTLVPLGISSWPVEVSYNLDAVLPKSDVVMMLRVQRERMSAAFFPTEREYSRRYGLDADRAEMLPDHALVMHPGPMVRGMEIASRVADSARSTVVEQVANGVSVRMAVLYLLLGGSGEVS
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: Y1755_PARUW
Sequence: MENMPYSQIQKGTFLIATPDIDSGFFFRGVILICEHNANGSFGLLINKSLDLELPEEIVNSEHLINPYISIRSGGPVQTNQMMLLHTSSQIQQQTLMITEGVYLGGDLQFLQDAITDQNGPHIHLCFGYSGWGAGQLEREFLDGHWFLHPAELRHVFYISPDKLWQHLLREMGGKYATLSMIPEDLSLN
What are the official names of this protein?
UPF0301 protein pc1755.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: YBDJ_KLEPN
Sequence: MKHPLETLLSAAGILLLALLSCLLLPAPSLGLTLAQKLVETFHMMDLNQLYTVLFCLWFLALGAIEYLVLRWVWRRWFSLER
What are the official names of this protein?
Uncharacterized protein in ramA 3'region.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MSD1_AMAFL
Sequence: MSDINATCLPAWLALCPCVGDDVNPTLTRGGT
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:24613547).
What are the official names of this protein?
MSDIN-like toxin proprotein 1.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: JGN1B_DANRE
Sequence: MASRAGPRATGTDGSDYQHRERVASHYQMSVALKSEIKKLNIAHAVVWFLVAAQVLVSQLNLVSHKVVASPYQWEYTYLLSIIPTVFSFMALPKNNISYLVISMISGGLFCIGPILYGGMEMFPVAQQLYRHGKAYRFIFGFSAVSIMYLVLIISVQVHGWQIYYSKKLLDAWFTNTQDKKKK
What is the function of this protein?
Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function.
What are the official names of this protein?
Protein jagunal homolog 1-B.
What is the protein family that this protein belongs to?
Belongs to the jagunal family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: Y149_NPVAC
Sequence: MNIIINMLGFNIFIETVYKFSDHTMERYHPYQRAPWSASIFKKNYNNVKVASYVEIPYTTNNADVEITYTTNAPSRPESKARRRLDFTNMTPLPCCIDDGSFAKPLL
What are the official names of this protein?
Uncharacterized 12.4 kDa protein in IE1-IEN intergenic region.
Protein: DEGS2_RAT
Sequence: MGNSAARSDFEWVYSDQPHTQRRKEMLAKYPSIKALMRPDPNIKWTVLGMVLVQVLACWLVRGLSWRWLLFWAYAFGGCINHSLTLAIHDISHNTAFGTRCASRNRWFAVFANLPIGLPYATSFKKYHVDHHRYLGGDGLDVDIPTDFEGWFFCTPARKLLWLVLQPFFYSLRPLYVNPKAVTRMEILNALVQLAFNVTIFALWGIKAIVYLLASSLLGLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNVGYHVEHHDFPSIPGCYLPLVRMIAPEYYDHLPQHHSWVKVLWDFVFEDSLGPYSRVKRKCKLAKDQL
What is the function of this protein?
Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.
What are the official names of this protein?
Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2, Degenerative spermatocyte homolog 2, Sphingolipid 4-desaturase, Sphingolipid C4-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: O3622_CONVE
Sequence: MSGLGIMVLTLLLLVSMATSHQDGGGKQATQRDAINVRRRRSITRREVVTEECEEYCKEQNKTCCGLTNGRPRCVGVCFG
What are the official names of this protein?
Conotoxin VnMSGL-0123.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O3 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PDXB_PSEF5
Sequence: MLIVADENIPLIEEFFAGFGEIRRFPGRAIDRATVEQADVLLVRSVTQVDRQLLEGSPVRFVGTCTIGTDHLDLEHFQQAGITWSSAPGCNARGVVDYVLGSLLTLAEIEGVDLAQRCYGVVGAGEVGGRLIEVLRGLGWNVLVCDPQRQAAEGGDYVSLEQLLERCDVISLHTPLTKSGQDSTWHLLDRQRLNRLRHGTWLINAARGPVVDNRALAEVLRQREDLQAVLDVWEEEPTVDASLADLCVLATPHIAGYSLDGKQRGTAQIYQAYCRFLGQAEQVSLSALLPAPWVPQVSLNANADPAWALAMICRAVYDPRRDDADFRRSLSDDVAQQRSAFDGLRKHYPERREIDGLEVRIQGESAALSRIVRALGAREA
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCAR1_MOUSE
Sequence: MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAVLQQQYSQPQQALYSVQQQLQQPQQTILTQPAVALPTSLSLSTPQPAAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLGAVKGKTPQVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQPLLKTPTAVIQPIVPQTTFGVQAQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRIVSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERDRERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAVLDPPDADHLYSAKVMLMASPSMEDLYHKSCALAEDPQDLRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSLDGPNPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRPEETHKGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKKADGEQDEEEKDDGEVKEIATPTHWSKLDPKAMKVNDLRKELESRALSSKGLKSQLIARLTKQLKIEEQKEEQKELEKSEKEEEDEDDKKSEDDKEEEERKRQEEVERQRQERRYILPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKDKEKKSKKEERKDKKEEREDDIDEPKPKRRKSGDDKDKKEDRDERKKEEKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEDDDREEEEVKRDDKRDVSRYCKDRPAKDKEKEKPQMVTVNRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLRESCFYRKLTDTSKDDENHEESEALQEDMLGNRLLLPTPTIKQESKDGEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEKTDEDGKTILNLENSNKSLSGELREVKKDLGQLQENLEVSENMNLQFENQLNKTLRNLSTVMDDIHTVLKKDNVKSEDRDEKSKENGSGV
What is the function of this protein?
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter.  Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone.  Also functions as a p53 coactivator.  May thus play an important role in transcriptional regulation.  May be involved in apoptosis signaling in the presence of the retinoid CD437.  Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A.  Plays a role in cell cycle progression and/or cell proliferation (By similarity).  In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).  Can act as a both a coactivator and corepressor of AR-mediated transcription.  Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites.  May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).
What are the official names of this protein?
Cell division cycle and apoptosis regulator protein 1, Cell cycle and apoptosis regulatory protein 1, CARP-1.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region.
Protein: DNAJ2_SYNY3
Sequence: MEQVRNYYQILGVPRNATAEEIKKSFRKLARQYHPDVNPNDKTAEEKFKDINEAYDVLSDETKRRELDSRLFGRFRRPPTSRFSPNSNGGRSPNGTSVNGQVRTPTGRTGTRQPAQSWQDFSETRRTKVVSPARPVPRDVEANLTLPLEKAYRGGKERIRLEDGRSLEVEMPGGMGDGQRIRLKQQGINGGDLYLKINLSPHPLFTLQGTDIACQVPVTPSEAILGGAIEVMTIDGLVKMTVPAGLKNGQKLRLAKKGFPNNQGDRGDQLVEIRVEIPPEPSPEELELYRRIREKETFNPRQKFFDF
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity).
What are the official names of this protein?
Chaperone protein DnaJ 2.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXJ_BRUA1
Sequence: MPAKLSVNLNAIAMLRNRRDLPWPSVTGLGRAALAAGAAGLTVHPRPDQRHIRFSDLGDIRALIDDEYPQAEFNIEGFPSEAFLDLVEKHEPEQVTLVPDDPMQATSDHGWDFMSKADFLAPIVARLKGRGMRVSLFADPDSLGYERAKAIGADRVELYTGPYGATHDDPAAAARELDRLEKAARAATALGLAVNAGHDLTVDNLPALVKRIPQLAEVSIGHGLTADALMYGIPVTVSRYITALAG
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_CHLL2
Sequence: MSIRTEKVASLLQQELGAILEKELPRSSALSTVVDVKVTADLGIARIYVSVIGTEEQRTAIMAWLHDETKYLRKLLSAKIRHHFRRIPEIEFFEDRIYERASRIEQLLREVRKAPEQHD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFS2_CANAL
Sequence: MYRSHNNNNNYHSRNDGSNGRINKPRDPKSQDKYVAYQQNIEQQLASQEKKQAYRRITDHGNNMGRWYIEKSLGLTNRSQQAIGTIRPESSYLIDLLPSLAYSSSFNLNRRNNKNNLAVLDLQTKFVHLSSNKVKHTINTVKWTPEGRRLLVASHSGEFTLWNGMTFNFETIMQAHESPILTMKYSNHDEWLLSGDQNGTVKYWQPNFNNVNNISAHANGVRDIAFSPNDSKFLTCGDDSAIKIWNFNNGKEERTLSGHHWEVKSADWHPNLGLIVSGSKDNLVKLWDPRSANCVSTLHGFKHTVNKTRFQPNGTARLLASVSRDRSCRIFDLRTMKDMLVIRDSETDLSCVAWHPIHASMVTTAAYNGSISNFLLDSYIPDSNESVPKRSNNNSNLSTNTNNTIDAVQKIPYAHEKAIHAVEYHPLGHLLCTAGSDKTARFWSRARPNDPMAWKDAVYTDCKAGAWYYSVNNNVNAVMEDPNAVKNEDDEIANNDDPLSNSGRRRGVGASASGGATGSVPGLRSRNETPNNGSYAIPGLRGF
What is the function of this protein?
Required for 3'-end cleavage and polyadenylation of pre-mRNAs.  Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).
What are the official names of this protein?
Polyadenylation factor subunit 2.
What are the subcellular locations of this protein?
Nucleus.