PharMolix/UniProtQA huggingface dataset:
Protein: SYI_ALCBS
Sequence: MTDYKATLNLPQTGFPMKAGLSQREPARLKEWQQKQLYQKIREAFAGRPKFILHDGPPYANGDIHIGHAVNKILKDMIVKSRTLAGFDAPYVPGWDCHGLPIELMVEKKVGKAGHKVDAGTFRKKCREYASKQVAGQKSDFMRLGVLGDWDNPYLTMDFTFEANIIRSLGKIVDNGHLQQGFKPVHWCLDCGSALAEAEVEYEDKISPAIDVAFPVVDVADFVARSGIEASAPALVIWTTTPWTLPANRAVAVHPELDYVLLSGELSGVARELLVAEALADDLVTRWGLENVTRSAAVAGSKLEMLALQHPFLEAQVPVVFGEHVTTDAGTGLVHTAPGHGVDDFMVGKQYDLDPISPVLDNGLFREDLPVVGGLHVSKANEPVIEALKDSGNLVKLAKIEHSYPHCWRHKTPLIFRATAQWFVSMDQAGLLPRARQEIDKVQWLPEWGKARIEGMLTDRPDWCISRQRTWGVPIALFVNKETSELHPQTPALIEQVAQRVEKAGVDAWFDLDPAELLGDEADQYSKVTDTLDVWFDSGVTHYCVLDQREQLRAPADLYLEGSDQHRGWFQSSLLTSLAIRDAAPYSTVLTHGFTVDEHGRKMSKSVGNVIAPQEVWNDLGADILRLWVCATDYRGEMSVSKDILKQMGDSYRRIRNTSRFLLSNLSGFEPATDALQPEQMLALDRYIVDRALQVQAEIQDLYDGYHFHQVYQKLHNFCALDLGGFYLDIIKDRQYTTQADSVARRSCQTALYHIAQALVRWMAPVLSFTAEEIYENLPGERLDSVFLAEWYDGLFALADNADMGRAFWDKVQDAKQAVNKAIEGARAAKLIKGSLSAEVVLFVDAEQNALLQRLGDELRFVTITSAAVLKPLAEAPAELEDTSVAGLKVQVLASDHAKCARCWHHQPDVGSHAEHPELCGRCITNVEGDGEVRHYA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRR2_YEAST
Sequence: MSLSRILRYNQRNNKTTASLTAEHAYSDNWAYSVSLGDPTSVGVNMAAKTGEALNKSYDSVFSSLPVADSVPRTDFTASSRDDENTDVQKLTTSWMEKIDTKMPENISKIDSNIISSPMVSKVEARFIVPKGRLRKNSTDFTSSFSNSLSLPKSYGKLIFFTSKKNSSSTKKNLANDISDNKHNNNSSNTIGHNIPVTTATATCDEIACTSTEHEYNVYEEERMFTTRVYSLEDSVSSLSTNPLDDTYSEAVQVNTRHIEDTESTAHIRKHSYTTSLSSIKRLFKITSFSNNNSNSCDHQESTVADDCAISSSLKETTSSPVSTGSFSLMIENEDSDRDQIIQALYSNIEASTDLVSRKYRDLDVVLGEGSGGKVKLVQRVLDNKVFALKEYRSKKKRESERKYIKNIISEYCIASTLKNPNICETLEILYEKGKIFQILEYCEYDLFSLVMSEKMHYEEICCLFKQLINGVKYLHDIGLSHRDLKLDNCVVTRRGILKLIDFGASSVFHYPLSSQMIEANGIVGSDPYLSPEVFYFNEYDPRALDVWSVGIIFFCMITRRFPWKYPKVKDVQFKAFCSGRGVSSFKDLVTRPATDDSNNYDNDGYEEGVIDMGPNFILHRLPEETHKIMRRILEVSPFRRITINGILQDGWIKEIETCQVVGAASPNEASLRIINKGNHIHTNIDQRYAHIGGLHQRT
What is the function of this protein?
Protein kinase that functions as regulator in the pheromone-induced mating pathway downstream of mitogen-activated protein kinase (MAPK) FUS3.  Diminishes transcriptional induction of genes in response to pheromone signaling.
What are the official names of this protein?
Serine/threonine-protein kinase PRR2, Pheromone response regulator 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: CHLL_SYNR3
Sequence: MTTTLTPPSSRREDGDGSVQVHQDASLKIEEGALVIAVYGKGGIGKSTTSSNLSAAFSKLGKRVLQIGCDPKHDSTFTLTHKMVPTVIDILEEVDFHSEELQPEDFVFEGFNGVMCVESGGPPAGTGCGGYVTGQTVKLLKEHHLLEDTDVVIFDVLGDVVCGGFAAPLQHANYCLIVTANDFDSIFAMNRIVQAIQAKAKNYKVRLGGVVANRSAETDQIDKFNERTGLRTMAHFRDVDAIRRSRLKKCTIFEMDKDEEGVEAVQNEYLLLAQNMLDHVEPLEAESLKDREIFDLLGFD
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: BOLA1_MOUSE
Sequence: MLSARSAQCMVSMATRSCVSRGSAGSAAAGPVEAAIRAKLEQALSPEVLELRNESGGHAVPAGSETHFRVAVVSSRFEGMSPLQRHRLVHEALSEELAGPVHALAIQAKTPAQWRENPQLDISPPCLGGSKKTRGTS
What is the function of this protein?
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity).  Probably acts together with the monothiol glutaredoxin GLRX5.  May protect cells against oxidative stress (By similarity).
What are the official names of this protein?
BolA-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the BolA/IbaG family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y1388_XANCB
Sequence: MLLPIPDVLTPAQLSQLRERLDAADWADGRITAGHQSAQAKDNAQLPEDSPIAREASALVLDALSRSSTFFSAALPRRIYPPLFNRYSGGQSFGYHVDNAVRYDRSRGGADPVRTDVSATLFLSDPESYDGGELVIEDTYGTQSVKLPAGHLVIYPGTSLHKVMPVTRGTRVASFFWIQSMLRNDAQRRLLFELDVSIRRLTQDTPGHPSLIQLTGVYHNLLRQWADV
What are the official names of this protein?
PKHD-type hydroxylase xcc-b100_1388.
Protein: SYN_ALIF1
Sequence: MTYAPVTDVLSGKLAVDSEVTVRGWIRSRRDSKAGISFLAVYDGSCFDPIQAVVPNDLNNYNDEVLKLTTGCSVEVTGTIVASPAKGQDFELAATEVKVVGWVEDAETYPMAKTRHSIEYLREVAHLRPRTNVIGAVARVRNCLSQAIHRFYHEQGYFWMSAPLITASDAEGAGEMFRVSTLDHANLPLDDKGNVDYDKDFFGKETFLTVSGQLNAETYACALSKVYTFGPTFRAENSHTSRHLAEFWMVEPEVAFATLDDVAKLAEDMLKYVFEAVLAERRDDLEFFASRIDKQAITRLEQFVSSDFAQVDYTDAIQILKDSGRDFEFDVEWGIDMSSEHERYLAEEHFKAPVIVKNYPKDIKAFYMRQNDDGKTVAAMDVLAPGIGEIIGGSQREERLDILDARMIEMGIDPEHMSWYRDLRRYGTVPHAGFGLGFERLVSYVTGMGNVRDVIPFPRTPRSANF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOA_SALTY
Sequence: MSMSTSTEVIAHHWAFAIFLIVAIGLCCLMLVGGWFLGGRARARHKNVPFESGIDSVGTARLRLSAKFYLVAMFFVIFDVEALYLFAWSTSIRESGWVGFVEAAIFIFVLLAGLVYLARIGALDWTPARSRRERMNPETNSIANRQR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RR4_BRAPI
Sequence: MSRYRGPRLKKIRRLGALPGLTRKTPKSGSNLKKKFHSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVHIAGKAKRSTGQVLLQLLEMRLDNILFRLGMAATIPGARQLVNHRHILVNGRIVNIPSFRCKPRDIITTKDNQRSQSLVQNSIASSDPGKLPKHLTIDTLEYKGLVNKILDRKWVGLKINELLVVEY
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GYAR_KORCO
Sequence: MKPRVFVTREIPERGLSKIEEHFELDLWKDEAPPSKKVIIERVKDCDALVSLLTDPIDAEVFEAAPKLRIVAQYAVGYDNIDVKEATKRGIYVTNTPGVLTETTADFAFALLMAAARRVVEADRYVREGKWKVAWHPMMMLGYDVYGRTLGIVGMGRIGAAVARRAKGFGMRILYYDSIRREDFEKELGVEYVPLEKLLEESDFVSLHVPLTEETYHMIGEEQLRRMKRTAILVNTSRGKVVDQKALYKALKEGWIAGAGLDVFEQEPIPPDDPLLKLENVVLAPHAASASHETRSRMAEMVAENLIAFKRGEIPPNLVNQEVVKVRPPGFQ
What are the official names of this protein?
Glyoxylate reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCSA_CUCSA
Sequence: MIFSTFEHILTHISFSVISIVITIQLITLLINETVGLYVSSEKGMIATFFCITGLLVTRWIYLRHLPLSDLYESLLFLSWAFSIIHLFTYFKKYKNHLSVSAITAPSTIFTQGFATSGFLTEMHQSPLLVPALQSHWLMMHVSMMVLGYAALLCGSLFSVALIVITFQKAIRIFCKNNNLLNALFSFNEIQYINEGNYFVRNTSFFSSKNYYKSQLIQQLDHWSYRIISLGFIFLSIGILSGAVWANETWGSYWNWDPKETWAFITWTIFAIYLHTRTNKNFEGVNSAIVASMGFLIIWICYFGVNLLGIGLHSYGSFTLTSN
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: URC4_LACKL
Sequence: MTVDNPVSYFKSISSVRETTKQVFDYVEQNDGQGNHFKMELSKMDDVVDFLCSIIARDYGTDYSSIPPHGRWQHLNCGNVLRVESLIEQWSGAGIDEVEISRKLIDLFVFSVLVDAGAGNTWKYTTTEEGNKAFDRSEGLAVASYYLFVQGALSQDTNDKFKVNGKKLTELTMDEFCQGFQVSDANPLNGTEGRLKLIQNLGVALSTNPAIFGKEGRPGCLVDYLYSKCTKDNGTAVVDLNDVWNALMDGFTSIWPAGRTSIDGEPLGDAWVLDTKAKASGSDAFLDSIVTFHKLTQWLCYSLLVPLENYGYKFTIKNKDMQTGLPEYRNGGLFYDFGVLTLTDGAYKRGLALTQKLGDNSSKIPTFTPEDGAIVEWRCLTIGLLDYLLPLVNKKLDYDLVLPQLIEAGSWKAGREIAAIKRPDTKGPPIELHSDGTVF
What is the function of this protein?
Involved in uracil catabolism.
What are the official names of this protein?
Uracil catabolism protein 4, Pyrimidine-degrading protein 14.
What is the protein family that this protein belongs to?
Belongs to the URC4/urg3 family.
Protein: SSPK_GEOSW
Sequence: MRNKERNFPNQNNNKFEGEPRAKAEYASKRANGTTNTHPQERMHASGKRDDNF
What are the official names of this protein?
Small, acid-soluble spore protein K, SASP K.
What is the protein family that this protein belongs to?
Belongs to the SspK family.
What are the subcellular locations of this protein?
Spore core.
Protein: RRP12_SCHPO
Sequence: MAEVNEPLQIELRKIRNSSTAGVINEFDVIVSAVEGTLKEQKTEATPTAYLVALLTLVKEFTDLKKNFKGHTFQLLELVIKYVPSNVLQAKFPQILSVLAPVVNNAETNKTVLLPYLNVLEKLLLLQDYSSWTHGNSCKTSIYILLFFALSNTEKTRVRSLQILANILKNPPAGPVTEHPAIKYTAFEPLRLLESLATAKKPKTPAEVQKLNNSLVLIRVLCSSTHWPMTLVERLCRSCVLIVGQRSTNSILLVYQILDGLSKKSVDYTDAVSLRMTLICLQKLEPSEHDPILMVGWLKAMNTAIRAFNILDKETAKYECLHRFKAFFTLLESESMEIRLQTATTICSVIGCLDTTPNSFAVVEEICSFICDALRDIRFRLAYPECFQIISSLCDKLGPHSDPYLIPALEVIDYLRGSEGFDGKALVDEAIGSFVRAIGPEAMLRVLPLNLELNDKDAVGRAWLLPVLRDNIRFANLAHFTNYFVPLSGQLYQKVIEMNDLDSIPSKLLQTLVDQIWSLLPGYCYLPLDLQSSFTLEFASILVNVLYEQVSLRSVICNSLTALVETNSKVADKLPLDDVISVPVSASDASSNLAFLTNMSSNFLSVLLNVFSSTPSQYRYPILKCIQTWIFISSNDTIHSVYKKVTDLLPDSLNDLAGSFNIAADGISSPMAYSLIDLLIVISPYLNQDYAVTLFEYVHEFLRHVNPAIQKKGYKLLGTLLRVDYGKAYATQHVKEIFEELSSVADRVVSSTRKDRLASLNALYELQSSELVIAIPQLLPEAIISLKEVNEKARHTAFQLLFNIAKSAVNSVEFGNSKPERVEKFVSVISAGLAGSSTHMISATIIAISSIVMEYKVFISEPFLVQLISTLNLFITSSKREIAKAAIDFIKISVSSFPVECIKPLLPELIPNLLAWSHEGKANLRVKVRHLFEKMGRKYGIAEIEPFFPAEDKKLITNIRKTQERNIRKRAMKRDPAKPSSAQPRKTFASAYEAAVYDTDDEAEEEFENDEMNNGNGGDLRMDEAFVQEDNDEEPLDLLDIEAVSKISSTDPRKKLAARKQKLNSAFKSNEEGRLLINDSDEDELIEDSLANAQQHAEVNRTYLEAVAGKESFRRGLNNRVKFSNKRVRDDYDEEMEEVEVPEVTRKPAKQKFDRKQRGQKGY
What is the function of this protein?
Required for nuclear export of the ribosomal subunits.  Required for maturation of the RNA components of pre-ribosomes (By similarity).
What are the official names of this protein?
Putative ribosomal RNA-processing protein 12.
What is the protein family that this protein belongs to?
Belongs to the RRP12 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: F16A1_CERSP
Sequence: MKPFPTHPDAIPAELQDVMDRLGSVAIEVANRIARGGIDEDLAGLCGTNTDGDGQKALDVIADDAFRVALEGSAVRFYASEEQDTAVTLNEAGTLALAIDPLDGSSNIDTNLSVGTTFAIWPAAPRPNPSFLRLGSELIAAGYVIYGPQVCMMVSFGKGTQKYVLDPGSRSFVLVDRAVKVPPSSTEFAINASNYRHWPKPIRAYIDDCVAGTEGPRGRNFNMRWLASLVAETHRILARGGVFLYPRDSRKGYEQGRLRYLYECAPIAFVITQAGGGATDGENPILGQTPSRLHARTPFVFGSAEKVARITAYHDLPEQETSALFGNRGLFRS
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1 1, FBPase class 1 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_BORDL
Sequence: MIFQKRTFFIKRGCVLNIRVRYAPSPTGLQHIGGIRTALFNYFFAKSFNGKFLLRIEDTDQTRYYKEAEEDLYQSLAWLGIDFDEGPTCGGSYSPYIQSQRTEIYRKYAKELIESGNAYYCYCSPDRLERIRKIQTINKMAPGYDRHCRHLNKDEIKDALSLGISPVIRFKIPFDGETSFNDILLGKITWANKDISPDPVILKSDGFPTYHLANVVDDHLMEISHVLRAQEWISSGPLHVLLYNAFRWNPPIYCHLPMVMGSDGQKLSKRHGATALKQFIDDGYLPEAIINYVTLLGWSYDGKSEFFTKNELQKLFSIDKISKSPAVFDYNKLDFFNSHYIRTKEDHELAELLLPFLQKAGYIKKDSNSCDKEKLLLLVPLIKPRIRKLGDAVGMLRFFYTNISTWNLNEFLGKKKTVRDIYLLLEKIKPVLEGFETRILSENEQIFYNFAKENDLKIGEVLLPIRIAVLGSKVSPPLFDSLQLLGKVTVFDRINKAQDFLKKYEL
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_PINAR
Sequence: MDEFHRYGKEDNSRQQCFLYPLFFQEDLYAISHDHYLDGSSSSEPTEHLSSNDQFSFLTVKRLIGQIRQQNHSIVLFVNCAPNPLADCKKSSYSESVLEGLTLVLEVPFSIRSKYSVEGMNEWKSFRSIHSIFPFLEDKFPHSNYISDARIPYSIHPEILVRTFRRLIRDAPSLHPLRSVLYEYRNSPENLQRSIIVVPRVNTRFFLFLWNYYVYECESILFSLLKRSSHSRSLSHRPFPQRTHFHRKIKHIIIFSRRNSLKSIWLLKDPKINYVRYGERSIIAIKGTHLLLKKCRYYLLLFRQCYFHLWSEPYRVCSHQLSKNCSSSPGYFLRVRMNPLFVRTKMLDELFIADLITNEFDPIVPIVPILGLLAREKFCDVSGRPISKLSWTNLTDDDILNRFDQIWRNLFHYYSGSFGRDGLYRIKYILSLSCAKTLACKHKSTIRVVRKELGPELFQKSFSKEREFDSLPFSSKAAARSQRERIWHSDIPQINPLVNSWQKIQDLKIENLFDQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ADCYA_HUMAN
Sequence: MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFETQEWEEGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMACLICNRKEDYPLLGRNKEINYFMYTMKKFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRIIAISLNKISFHQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIFHVQFPISREISRMSTLKKQKQLEILFMKILKLIVKEERIIFIIDEAQFVDSTSWRFMEKLIRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISKELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLNMVTLHSDKESEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLKPSEGMDHGEEEQLRELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEEDAHRCDHCRGRDFIPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAFFPENRSPEEIREKILNFFDHVLTKMKTSDEDIIPLESCQCEEILEIVILPLAHHFLALGENDKALYYFLEIASAYLIFCDNYMAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKKRLAQLYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYHHLAGYKGVWFKYEVMAMEHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQNPNRHYQSLCRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHSGLLLGLYSSVAIWYARLQEWDNFYKFSNRAKNLLPRRTMTLTYYDGISRYMEGQVLHLQKQIKEQSENAQASGEELLKNLENLVAQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRLSETQGNILEKCWLNMNKESWYSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFLMRANTVDNHF
What is the function of this protein?
Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411).  May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988).  Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis.  Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity).  Involved in ciliary beat regulation (PubMed:17591988).
What are the official names of this protein?
Adenylate cyclase type 10, AH-related protein, Adenylate cyclase homolog, Germ cell soluble adenylyl cyclase, hsAC, sAC, Testicular soluble adenylyl cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Nucleus. Cell projection, cilium. Cytoplasm. Mitochondrion. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.
Protein: RL22B_CANAL
Sequence: MAPVTSKKSKSVKKFVVDVAAPVENDVFDQESYVKYLVEHVKVDGIVGNLGNDISITAESDNKVVVVVSGNGSFSGKYLKYLTKKYLKKNQIRDWIRFVSVKQNQYKLQFYAVAEDDEEEEDEE
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L22-B.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL22 family.
Protein: DTD_GLAP5
Sequence: MIGLIQRVKWAKVEVDNQTVGEISMGLLVLLGVEQGDDQAKADRLLEKVLNYRVFADEQGKMNLNVQQAGGSLLVVSQFTLAADTQKGLRPSFSRGATPALAQALYDYFHQQAALKIHTQTGRFAADMQVSLQNDGPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMYL_LACAM
Sequence: MKQLNSEQLQNIIGGNRWTNAYSAALGCAVPGVKYGKKLGGVWGAVIGGVGGAAVCGLAGYVRKG
What is the function of this protein?
This heat stable bacteriocin inhibits the growth of closely related Lactobacillus species.  It may act as a pore-forming protein, creating a channel in the cell membrane.  It kills Lactobacillus helveticus ATCC 15009, but displays no activity towards Listeria species.
What are the official names of this protein?
Bacteriocin amylovorin-L, Amylovorin-L471, Lactobin-A.
What is the protein family that this protein belongs to?
Belongs to the bacteriocin class IIB family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Single-pass membrane protein.
Protein: PNO1_CHATD
Sequence: MPAPTALKQPPPAPEQQAAPAITNENEDELLIDIQQAAATLTDPNAAEPPEETMENEMAVDEEGRPRFAPGKNIDPIRRIETRKIPIPPHRMSALKANWTKYPPLVDHCKLQVRMNIKEKRVELRSSKYTVSNEALQMGADFVSAFAMGFDIDDAIALLRLDSLYIQSFDIKDVRQTLGPDALSRAIGRIAGKDGKTKFAIENATKTRIVLAGSKVHILGAFENIGMARESIVSLVLGAQPGKVYNNLRIIASRMKERW
What is the function of this protein?
Required for small ribosomal subunit (SSU) synthesis.  Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.
What are the official names of this protein?
Pre-rRNA-processing protein PNO1.
What is the protein family that this protein belongs to?
Belongs to the PNO1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: DNAK_FRATN
Sequence: MGKIIGIDLGTTNSCLAIMDGKTAKVIENAEGHRTTPSVVAYTDSGEILVGQAAKRQAVTNPDNTFFAIKRLIGRKYDDKAVQEDIKKKVPYAVIKADNGDAWVATKEGKKMAPPQVSAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGKIAGLEVKRIINEPTAAALAYGVDSKKGEQTVAVYDLGGGTFDISIIEIADVDGDNQIEVLSTNGDTFLGGEDFDLALMNYLIDEFKKEQGIDLHNDKLALQRVREAAEKAKVELSSAQQTDVNLPYITADATGPKHLNIKVTRAKFESLVSDLVMRSLEPCKKALEDAGLSKSDITEVLLVGGQTRMPLVQEKVKEFFGKEPRKDVNPDEAVAVGAAIQGGVLAGDVKDVLLLDVTPLSLGIETMGGVMTKLIERNTTIPTKKSQVFSTAEDNQPAVTIHVLQGEREMASANKSLGRFDLADIPPAPRGMPQIEVTFDIDANGILNVSAKDKATGKEQNIVIKSSSGLSEEDIEKMVQDAEANAEADKKFHDLVTARNTADNLIHSSRKAIQELGDKVTAAEKEKIEEACKELEAATKSDDKQAIEAKTKALEEAFAPIAQKAYAEQAQAAGAQGGAKAEEPKKEEDVVDADFEDVEDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ID2_BOVIN
Sequence: MKAFSPVRSVRKNSLSDHGLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQSQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG
What is the function of this protein?
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity.  Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.  Inhibits skeletal muscle and cardiac myocyte differentiation.  Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer.  Restricts the CLOCK and BMAL1 localization to the cytoplasm.  Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity).
What are the official names of this protein?
DNA-binding protein inhibitor ID-2, Inhibitor of DNA binding 2, Inhibitor of differentiation 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RBFA_STAAN
Sequence: MSSMRAERVGEQMKKELMDIINNKVKDPRVGFITITDVVLTNDLSQAKVFLTVLGNDKEVENTFKALDKAKGFIKSELGSRMRLRIMPELMYEYDQSIEYGNKIERMIQDLHKQDR
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.