PharMolix/UniProtQA huggingface dataset:
Protein: CYOB_BUCAP
Sequence: MFGKLTLKAIPVDEPIIMVTYISIILIALFISFSITYFKKWKYLWYEWFTTVDHKKISIMYGILAFIMLFRGFVDAILMRTQQVIASSGNTGFLPPHHYDQIFTAHGVIMIFFVAMPLVIGLMNLVVPLQIGARDVAFPFLNNLSFWLNVSGAILLTLSLGIGEFAQTGWLAYPPLSEVKYSPGVGVDYWIWSLQISGVGTTLTGINFLITILKMRAPGMCFFKMPVFTWAALCTNILIVISFPVLTTTLLLLTLDRCFDFHFFTNNFGGNPMMYVNLIWIWGHPEVYILVLPVFGVFSEVVATFSKKRLFGYVSLVWATLAITILSFIVWLHHFFTMGAGSNVNAFFGITTMIIAIPTGVKIFNWLFTMYQGRVHMHSSMLWTIGFLITFSIGGMTGVLLSIPPADFILHNSLFLVAHFHNVIIGGVVFGCFAGINYWFPKLFGFILNELWGKRAFWFWIIGFFTAFMPLYFLGFMGMTRRLSQNIDIEFHFLLSIAAIGAILIGIGILCQIIQFWVSVRDRHINLDVTGDPWDGRTLEWSTSSPAPLYNFAIIPHIKNKDDFWELKKQKNQVQKKQYSAIHMPKNTGLGIFISFFSLLFGFSAVWNIIWLSFLSFLVVIISLIFKSIDENTEYTVSVKEIESIENRHLENVQKAGLK
What is the function of this protein?
Cytochrome bo(3) ubiquinol oxidase is the terminal enzyme in the aerobic respiratory chain.  Catalyzes the four-electron reduction of O2 to water, using a ubiquinol as a membrane soluble electron donor for molecular oxygen reduction.  Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron and generating a proton motive force.  All the redox centers of this enzyme complex are located within the largest subunit, subunit I.  Protons are probably pumped via D- and K- channels found in this subunit.
What are the official names of this protein?
Cytochrome bo(3) ubiquinol oxidase subunit 1, Cytochrome o ubiquinol oxidase subunit 1, Cytochrome o subunit 1, Oxidase bo(3) subunit 1, Ubiquinol oxidase polypeptide I, Ubiquinol oxidase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURC_BURL3
Sequence: MKHIVKHIHFVGIGGAGMSGIAEVLVNLGYEVSGSDLSRNAVTDRLQALGARIAIGHDAVNIEGANAVVVSTAVRSDNPEVLAARAKRVPIVQRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAAGGLDPTFVIGGRLISAGANARLGTGDFIVAEADESDASFLNLYPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGSAVVCVDDPNVRQIIPFISKPVVRYGLSPDAQVRAEDIDARDGRMHFTVIRDGRAPLAVVLNMPGLHNVQNALAAIAIATDLGVSDDAIQLALAEFNGVGRRFQRYGEVPAADGGQYTLIDDYGHHPVEMAATIAAARGAFPGRRLVLAFQPHRYTRTRDCFDDFVNVLSTVDALVLTEVYAAGEAAISTANGDALSRALRTVGKVDPVFVATVDDVPDALAKVAQNGDVVITMGAGSIGGVPAKVAQHTQQKA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_SOLUE
Sequence: MNLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESSGHRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCFFRRLDAGEWKVADNPTYDPGAVYGGKS
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_PORGI
Sequence: MEIAKIIGREILDSRGNPTVEVDVHLACGIIGRAAVPSGASTGENEAIELRDQDKARYCGKGVLKAVKNVNEVIDPALCGMSVLEQTAIDRKLIELDGTKTKSNLGANAMLGVSLAVAKAAAAYLDIPLYRYIGGSNTYVLPVPMMNIINGGSHSDAPIAFQEFMIRPVGACCFREGLRMGAEVFHALKKVLHDRGLSTAVGDEGGFAPALNGTEDAIESILKAVEAAGYVPGKDITIAMDCASSEFFKDGIYDYTKFEGEKGKKRSIDEQVAYLTELVGKYPIDSIEDGMSENDWEGWKKLTVALGDKVQLVGDDLFVTNVEFLRRGIAEKCGNSILIKVNQIGTLTETLNAIEMAHRHGFTSVTSHRSGETEDTTIADIAVATNSGQIKTGSLSRTDRMAKYNQLLRIEEELGPCAVYGYKKV
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: IKBA_RAT
Sequence: MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEDYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKTLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLGIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQTLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL
What is the function of this protein?
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals.  On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity).
What are the official names of this protein?
NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, RL/IF-1.
What is the protein family that this protein belongs to?
Belongs to the NF-kappa-B inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Protein: XNI_SALPC
Sequence: MAAHLLIVDALNLIRRIHAVQGSPCVETCQHALDQLIIHSQPTHAVAVFDDDARSSGWRHQRLPDYKAGRPPMPDDLHNEMPALRAAFEQRGVRCWASDGNEADDLAATLALKVTEAGHQATIVSTDKGYCQLLSPGLRIRDYFQKRWLDAPFIEKEFGVLPRQLPDYWGLAGISSSKVPGVAGIGPKSATQLLIQFQNLEGIYAHLDKVPEKWRKKLETHKEMAFLCRDIARLQTDLHIDGNLQQLRLAR
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: SHH_HUMAN
Sequence: MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALGPRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGAADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS
What is the function of this protein?
The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development.  Induces ventral cell fate in the neural tube and somites (PubMed:24863049).  Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity).  Essential for axon guidance (By similarity).  Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (PubMed:10753901).  In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (PubMed:10753901).
What are the official names of this protein?
Sonic hedgehog protein, SHH, HHG-1, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, ShhNC.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
[Sonic hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Secreted. Note=Co-localizes with HHAT in the ER and Golgi membrane. SUBCELLULAR LOCATION: [Sonic hedgehog protein N-product]: Cell membrane; Lipid-anchor. Note=The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (PubMed:24522195). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides (PubMed:26875496, PubMed:24522195).
Protein: CCR2_MEDTR
Sequence: MPAYDNTSSVSGGDQTVCVTGAGGFIASWLVKLLLERGYTVRGTVRNPEDPKNGHLKELEGARERLTLHKVDLLDLQSIQSVVHGCHGVFHTASPVTDNPDEMLEPAVNGTKNVIIASAEAKVRRVVFTSSIGTVYMDPNTSRDVVVDESYWSDLEHCKNTKNWYCYGKTVAEQSAWDIAKENQVDLVVVNPVVVLGPLLQPTINASTIHILKYLNGAAKTYVNATQSYVHVKDVALAHLLVYETNSASGRYICCETALHRGEVVEILAKYFPEYPLPTKCSDEKNPRVKPYKFSNQKLKDLGLEFTPVKQCLYDTVRSLQEKGHLPIPPMQEDSA
What is the function of this protein?
Involved in the latter stages of lignin biosynthesis (PubMed:20876124).  Catalyzes one of the last steps of monolignol biosynthesis, the conversion of cinnamoyl-CoAs into their corresponding cinnamaldehydes (PubMed:20876124).  Mediates the conversion of caffeoyl-CoA and coumaroyl-CoA to caffaldehyde and coumaraldehyde, respectively (PubMed:20876124).  Also active, with a lower efficiency, toward feruloyl-CoA and sinapoyl-CoA (PubMed:20876124).  Involved in the production of floral volatile phenylpropanoids in flowers of fragrant cultivars from cinnamic acid, a common precursor with the anthocyanin biosynthesis pathway involved in flower pigmentation (By similarity).
What are the official names of this protein?
Cinnamoyl-CoA reductase 2, Mt-CCR2, Caffeoyl-CoA reductase, Coumaroyl-CoA reductase, Feruloyl-CoA reductase, Sinapoyl-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Protein: ECHD1_HUMAN
Sequence: MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELYLEEALQNERDLLGTVWGGPANLEAIAKKGKFNK
What is the function of this protein?
Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388).  Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).
What are the official names of this protein?
Ethylmalonyl-CoA decarboxylase, Enoyl-CoA hydratase domain-containing protein 1, Methylmalonyl-CoA decarboxylase, MMCD.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: HEM1_CHLT2
Sequence: MVREGEERIGNRVLLGVIGVSYRETTLQQREQVLHILQQAQGSFRPEVFQEERDYVLLATCHRVELYSVAPAELFDSLAQEIKLLGVSPYFYRNQDCFAHLFCVAGGLDSLVLGETEIQGQVKRAYLQAAREQKLSFALHFLFQKALKEGKVFRAKGGAPYAAITIPILVDQELRRRQIDKKASLLFIGYSEINRSVAYHLRRQGFSCITFCSRQQLPTLSMRQVVREELCFQDPYRVVFLGSLELQYALPHSLWESIWDIPDRIVFDFAVPRALPSHTVFPHRYMDMDQISDWLREHRKEVNSAHLDSLREVAYRYWNSLNQRLERHDCVGANA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: CITS_BACSU
Sequence: MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQAEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIRSASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVDFLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRERNAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKGEMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDLRAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILLGKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLFFITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWIELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG
What is the function of this protein?
Member of the two-component regulatory system CitT/CitS.  Regulates the expression of the citM-yflN operon.  Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex.
What are the official names of this protein?
Sensor protein CitS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MFP2_ACRMI
Sequence: FSPDCTWTIRNSGISQPVAIVSIEEVQFGYCRGYIKVFDGSGAQIFTREGCHENHSSNAFLEIAFQESQNVTIQVSLQNNQSYARVGYGILEDDLESASLLPAWNVAIENKT
What are the official names of this protein?
MAM and fibronectin type III domain-containing protein 2.
What are the subcellular locations of this protein?
Secreted.
Protein: ICP27_HHV6U
Sequence: MYPRGVKRSHHDYHRQTAFRTIKRSTHRQTSKFISHFAKNFRGKLAPLKQLDESRLDALSLTELEQLKTIIEEKQQEKRAQNNAITFLPNLPTVPFADTNFSLKSLGLRPYNGDARDPKQRIRDRFPQTHERICLLTNDILETDLLLRYRQCLDSLTREENQQLMGDRIFSLTNSPCLAFTVATVEEACSYFKFHDLHNLPVNPQDLFMYTITVMKFEFFNKLNMAKLTCVFNDNGHGDIEYRKLRQLCGKPVLDREMPNSELEVQQQTPDSFRHPIQQAMSIVVTFARILRQIKEQIIQTKKPQFIRDFDTGRVAERYECGLMSRLIGKQFSNHKCDDVSCQNRIERIMAPWKPSLFFCTYFAKDAPKFKLFPNFPEEYRNLSFTCPKVDTEPSCSYSTNHDLPQTSHRSHKNHGTPKVKSKVCVEKPDTSILTTTKTTTEILIEESMETDNKIPNPRELNFNQAKQEEIVIININENVNSKHESESSVEMDLDLDYEADTCETNLNACSSDSE
What is the function of this protein?
Immediate early (EI) protein that plays many roles during productive infection including regulation of viral gene expression and nuclear export of intronless viral RNAs.
What are the official names of this protein?
mRNA export factor ICP27 homolog.
What is the protein family that this protein belongs to?
Belongs to the HHV-1 ICP27 protein family.
What are the subcellular locations of this protein?
Virion tegument. Virion. Host nucleus. Host cytoplasm. Note=Shuttles between host nucleus and cytoplasm.
Protein: C76M6_ORYSJ
Sequence: MEKLKSELWMTAVATCMSLLLYLTILRRRHASGGRSLALPPGPTPLPLIGNLLCLGGIFHQTLAKLARVHGPVMTLKLGLTTAVVVSSAEAAREAYTKHDQRLAARPVPDAFRANGFSERSIVFSPSSDPQWKNLRGIHATHIFSPRALAALRGIRERKVRDIVGYIRTVAGEEMCVREVVHNGVLNLISTSFFSMDMADVRSESARGLRGLIEDIIATVAGPNVSDFFPFLRQLDLQGLRRQTGSHLGIVFGLLDDIIDRRMAETRDHPDKQRHGDFLDALISLASAGKIPRYHITYLLFDVFAAGADTMTTTVEWAMAELLRNPRVMAKVRAEVTDALGGRESFDEGDAASLTYLQCVFKEAMRLHPVGSILVPHLAVQDGVEIGGYAVPKGTTVIFNAWAIMRDPAAWESPDQFLPERFLHKEESSSPPLELRGKDYEYIPFGSGRRLCPGLPLAERAVPFILASLLHAFEWRLPDGMSPDDMDMTEKFATANVLATPLKAVPVASHTS
What is the function of this protein?
Enzyme of the diterpenoid metabolism involved in the biosynthesis of the oryzalexin class of phytoalexins.  Can use ent-sandaracopimaradien and syn-stemodene as substrates, but no activity with syn-stemoden-19-oic acid.  Hydroxylates 3-alpha-hydroxy-ent-sandaracopimaradiene at C-9-beta, resulting in a 3-alpha,9-beta-diol corresponding to oryzalexins E.
What are the official names of this protein?
Oryzalexin E synthase, Cytochrome P450 76M6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DNMT1_CHICK
Sequence: MPARSAPPPPALPPALRRRLRDLERDEDSLSEKETLQEKLRLTRGFLRAEVQRRLSALDADVRCRELSEERYLAKVKALLRRELAAENGDAAKLFSRASNGCAGNGEEEWERGGRGEDGAMEVEEAAASSSSSSSSSSSSSSSSSSSSSLLPAPRARKARRSRSNGESKKSPASSRVTRSSGRQPTILSVFSKGSTKRKSEEVNGAVKPEVSAEKDEEEEEELEEKEQDEKRIKIETKEGSEIKDEITQVKTSTPAKTTPPKCVDCRQYLDDPDLKFFQGDPDDALEEPEMLTDERLSIFDANEDGFESYEDLPQHKVTSFSVYDKRGHLCPFDTGLIERNIELYFSGAVKPIYDDNPCLDGGVRAKKLGPINAWWITGFDGGEKALIGFTTAFADYILMEPSEEYAPIFALMQEKIYMSKIVVEFLQNNRDVSYEDLLNKIETTVPPVGLNFNRFTEDSLLRHAQFVVEQVESYDEAGDSDEPPVLITPCMRDLIKLAGVTLGKRRAVRRQAIRHPTRIDKDKGPTKATTTKLVYLIFDTFFSEQIEKDEREDDKENAMKRRRCGVCEVCQQPECGKCKACQNMVKFGGSGRSKQACLQRRCPNLAVREADEDEEVDDNIPEMPSPKKMLQGRKKKQNKSRISWVGEPIKSDGKKDFYQRVCIDSETLEVGDCVSVSPDDPTKPLYLARVTAMWEDSSGQMFHAHWFCPGSDTVLGATSDPLELFLVDECEDMQLSYIHGKVNVIYKPPSENWAMEGGLDMEIKMVEDDGRTYFYQMWYDQEYARFETPPRAQPMEDNKYKFCLSCARLDEVRHKEIPKVAEPLDEGDGKMFYAMATKNGVQYRVGDSVYLLPEAFSFSMKPASPAKRPKKEAVDEDLYPEHYRKYSEYIKGSNLDAPDPYRVGRIKEIFCHIRTNGKPNEADIKLRIWKFYRPENTHKSMKATYHADINLLYWSDEETTVDFCAVQGRCTVVYGEDLTESIQDYSAGGLDRFYFLEAYNAKTKSFEDPPNHARSSGNKGKGKGKGKGKGKGKSSTTCEQSEPEPTELKLPKLRTLDVFSGCGGLSEGFHQAGVSETLWAIEMWEPAAQAFRLNNPGTTVFTEDCNVLLKLVMSGEKTNSLGQKLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIVLAAAPGEKLPMFPEPLHVFAPRACQLSVVVDDKKFVSNITRTYSGPFRTITVRDTMSDLPEIRNGASALEISYNGEPQSWFQRQIRGSQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTSTRKLRYTHHEKKNGRSSSGALRGVCSCAEGKPCDPADRQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIRACVGARMREESGAAVAPPAPEKMEMTAAAD
What is the function of this protein?
Methylates CpG residues.  Preferentially methylates hemimethylated DNA.  It is responsible for maintaining methylation patterns established in development.  Mediates transcriptional repression by direct binding to HDAC2.  Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes.  Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs).  Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing.
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase 1, Dnmt1, DNA methyltransferase GgaI, DNA MTase GgaI, M.GgaI, MCMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CHLL_ANTAG
Sequence: MKIAVYGKGGIGKSTTSCNTSIASARRGKRVLQIGCDPKHDSTFTLTGSLIPTIIDTSQSKDYHYEDVWPEDVIYKGYGGVDCVEVGGPPAGAGCGGYVVGETVKLLKELNAFYEYDIILFDVSGDVVCGGFVVLLNYADYCIIITDNGFDALFAVNCIAASVREKARTHSLRLAGSVGNRTSKRDLINRYVEACPMPVLEVSLLIEDIRVSRVKGKTSFEMVEFQPFLNYVCEFYLNIADQILSQPEGVIPKEIPDRELFSLLSDFYLNPTNNERENKNQETLLDFMII
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CSPLA_SORBI
Sequence: MAASGLKVPEMALRVCVVPLALASLWEMATNAQADDTYGEVKFSDLSGFSYLVGVNAVTAAYALVSILLSSLKPLARYDWVILVMDQASAYLLVTSASAAAELLQLARRGDREVSWGEVCSYFGRFCGKATVSLALHAAALACFVALALVSAFRVLSTTGSSCHPPKHAQAQEHEQGRYN
What are the official names of this protein?
CASP-like protein 2D1, SbCASPL2D1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DEOC_MYCTO
Sequence: MLGQPTRAQLAALVDHTLLKPETTRADVAALVAEAAELGVYAVCVSPSMVPVAVQAGGVRVAAVTGFPSGKHVSSVKAHEAAAALASGASEIDMVIDIGAALCGDIDAVRSDIEAVRAAAAGAVLKVIVESAVLLGQSNAHTLVDACRAAEDAGADFVKTSTGCHPAGGATVRAVELMAETVGPRLGVKASGGIRTAADAVAMLNAGATRLGLSGTRAVLDGLS
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WAPA_PSEAU
Sequence: MSSGGLLLLLGLLTLWGVLTPVSSKDRPKKPGLCPPRPQKPCVKECKNDWSCSGQQKCCNYGCIDECRDPIFVN
What is the function of this protein?
Damages membranes of susceptible bacteria.  Has no hemolytic activity.  Not toxic to mice.  Does not inhibit the proteinases elastase and cathepsin G.
What are the official names of this protein?
Auswaprin-a.
What is the protein family that this protein belongs to?
Belongs to the snake waprin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MNTB_LISIN
Sequence: MNIQGLTIAYKQKVAIDDVTLQIATGKLTGIVGPNGAGKSTLLKGMMGLVPREKGQVTLDNKPLTYWRKKIAYVPQRSEVDLTFPITVFDMVLLGTYPALGLIKRPGKKEKQLAFDALEQVEMTAFSKRQIGELSGGQLQRVFIARALAQHAEIFFLDEPFAGIDMASEALIMKLLKKLRDNGKTIVVVHHDFHKVAAYFDDIILLNKKLVAHGPVEQTFTEEKIQFAYGDAPVAFAAGV
What is the function of this protein?
This protein is probably a component of a manganese permease, a binding protein-dependent, ATP-driven transport system.  Probably responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Manganese transport system ATP-binding protein MntB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y1300_PYRFU
Sequence: MRKGSVKEVLAKIKYDPRENEEDYFIIIEHRGSYGNVRKIPVSLIELGHGYFFVGETQIPYHRILKVVRKDGRVVWESRKRGLK
What are the official names of this protein?
UPF0248 protein PF1300.
What is the protein family that this protein belongs to?
Belongs to the UPF0248 family.
Protein: C12C1_DROME
Sequence: MLRLTVKHGLRANSQLAATRNPDASSYVQQLESEWEGAKPFTELPGPTRWQLFRGFQKGGEYHQLGMDDVMRLYKKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGLFGNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPGDFMNTINHLTFESVATVALDRELGLLREANPPPEASKLFKNIEVLMDSFFDLGVRPSLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGDSNDHKSVLEQLLQIDRKLAVVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIEYNYSTEKPYKCRFLYKPNIPLKFKFTDLKY
What are the official names of this protein?
Probable cytochrome P450 12c1, mitochondrial, CYPXIIC1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion membrane.
Protein: KRE28_YEAS8
Sequence: MDTGSASIKDYETVLTDIEDSIAVSSEEVLNNQELRLKNTLHEITSSILAINEENKFVNPLRNDESLDVEGKEVFVNPKILSAKIKEFNKLMELLKLTYLEQETLDYFFRFTLSSTKPLQLDSEKDPQFVKLNERVNDLKEEISNVQESKIEQIKAEIQETGHNFAEKQDLINELYLEATGDIENCWDSLNELKNLTNKEDKNMMGEKDTILNSSDSDDFVEETYTNWQKLLFLQKQNQRLTKELKEMHEVKNQIIRKGEQSKKEDSGHLMANESELCQSINLLTKFWEKHFLLKGSKTTILNFEIFTQLGKVQFEIKDMQYIIAISLSDLKRPMIKDITILQKAGGNIVTDIEANSKFNNKYRNNTKVQIFEVMDDIISELTNE
What is the function of this protein?
Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3).  Involved in kinetochore-microtubule binding and the spindle assembly checkpoint (By similarity).
What are the official names of this protein?
Spindle pole body component KRE28.
What is the protein family that this protein belongs to?
Belongs to the KRE28 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Chromosome, centromere, kinetochore. Note=Localizes to the nuclear side of the spindle pole body.
Protein: Y856_TREPA
Sequence: MVHYKSVFYKSAALVCGFVLAGASVAIASSEAAAKTRSKMSEFKRRAVSSPSGGRLSVLDGSFTALANDASFFEANPAGSANMTHSELTFAHTVGFNNSHAETLSYVGQSGNWGYGASMRMFFPESGFNFSPSTGPVCTPASNPIKKLGGLGIVNFSRRFGGLSIGANLKAGFRDAQGLTHLSLGTDVGLQWVGNVAKFFSSAEPNMYVGLSATNLGFTVKLPGSPFVLCRATGEQCCKTCSGRCTGVGTCCNGEKPCCKDCDCNCPCQDEATPGSPHATDTMLRAGFAYRPLSWFLFSVGVATRVNVSNLQVDHSGSALPMRLG
What are the official names of this protein?
UPF0164 protein TP_0856.
What is the protein family that this protein belongs to?
Belongs to the UPF0164 family.