PharMolix/UniProtQA huggingface dataset:
Protein: ZA2G_MOUSE
Sequence: MVPVLLSLPLLLGPAVFQETGSYYLTFLYTGLSRPSKGFPRFQATAFLNDQAFFHYNSNSGKAEPVGPWSQVEGMEDWEKESQLQRAREEIFLVTLKDIMDYYKDTTGSHTFQGMFGCEITNNRSSGAVWRYAYDGEDFIEFNKEIPAWIPLDPAAANTKLKWEAEKVYVQRAKAYLEEECPEMLKRYLNYSRSHLDRIDPPTVTITSRVIPGGNRIFKCLAYGFYPQRISLHWNKANKKLAFEPERGVFPNGNGTYLSWAEVEVSPQDIDPFFCLIDHRGFSQSLSVQWDRTRKVKDENNVVAQPQ
What is the function of this protein?
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers.
What are the official names of this protein?
Zinc-alpha-2-glycoprotein, Zn-alpha-2-GP, Zn-alpha-2-glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Secreted.
Protein: CQ082_HUMAN
Sequence: MGRPLEGQPLRALDLYPEPAFLRSGKDPKSSPASSPSFAVLGPEVRSTGGQAGSRRRPSAPCSQDRAAAEGAPALLGGSPSSGSPGHPPGSAFGVEAGCRALNVSEHARGGFALGLPFGLSGGAYLFLLLDGAGDPKPTPEAPISSADGRAWFPSESSWQLPQLPAGSTSGSEPRARPGLGPRQLLTGPRDGAAGQGPGRGLTARLGREREIDCGPRQAGHGGTATDTGRAGSGARHRPPRDRGTPGLRTH
What are the official names of this protein?
Putative uncharacterized protein LINC02875.
Protein: SUCC_ECOSE
Sequence: MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGAGPWVVKCQVHAGGRGKAGGVKVVNSKEDIRAFAENWLGKRLVTYQTDANGQPVNQILVEAATDIAKELYLGAVVDRSSRRVVFMASTEGGVEIEKVAEETPHLIHKVALDPLTGPMPYQGRELAFKLGLEGKLVQQFTKIFMGLATIFLERDLALIEINPLVITKQGDLICLDGKLGADGNALFRQPDLREMRDQSQEDPREAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGEPANFLDVGGGATKERVTEAFKIILSDDKVKAVLVNIFGGIVRCDLIADGIIGAVAEVGVNVPVVVRLEGNNAELGAKKLADSGLNIIAAKGLTDAAQQVVAAVEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RNH2_STRPC
Sequence: MSTSIKAIKESLEAVTSLLDPLFQELATDTRSGVQKALKSRQKAIQAELAEEERLEAMLSYEKALYKKGYQAIAGIDEVGRGPLAGPVVAACVILPKYCKIKGLNDSKKIPKSKHETIYQAVKEKALAIGIGIIDNQLIDEVNIYEATKLAMLEAIKQLESQLTQPDYLLIDAMTLDIAISQQSILKGDANSLSIAAASIVAKVTRDQMMANYDRIFPGYGFAKNAGYGTKEHLQGLKAYGITPIHRKSFEPVKSMCCDSTNP
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTRC_MOUSE
Sequence: MEGALTARQIVNEGDSSLATELQEEPEESPGPVVDENIVSAKKQGQSTHNWSGDWSFWISSSTYKDRNEEYRQQFTHLPDSEKLIADYACALQKDILVQGRLYLSEKWLCFYSNIFRWETTISIALKNITFMTKEKTARLIPNAIQIITEGEKFFFTSFGARDRSYLIIFRLWQNVLLDKSLTRQEFWQLLQQNYGTELGLNAEEMEHLLSVEENVQPRSPGRSSVDDAGERDEKFSKAVSFTQESVSRASETEPLDGNSPKRGLGKEDSQSERNVRKSPSLASEKRISRAPSKSLDLNKNEYLSLDKSSTSDSVDEENIPEKDLQGRLYINRVFHISAERMFELLFTSSHFMQRFANSRNIIDVVSTPWTVESGGNQLRTMTYTIVLSNPLTGKYTAATEKQTLYKESREAQFYLVDSEVLTHDVPYHDYFYTLNRYCIVRSAKQRCRLRVSTDLKYRKQPWGLIKSLIEKNSWSSLESYFKKLESDLLMEESVLSQSIEDAGKHSSLRRRRRTLNRTAEPVPKLSSQRSSTDLGFEAKVDVTGKRKTVDSYDTALIVVMSIFLLLLVLLNVTLFLKLSKIEHATQSFYQLHLQGEKSLNLVSDRFSRTENIQKNKDQAHRLKGVLQDSIVMLEQLKSSLIMLQKTFDLLNKNKSGVAVES
What is the function of this protein?
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461).  Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461).  Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461).  In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461).  At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461).
What are the official names of this protein?
Protein Aster-C, GRAM domain-containing protein 1C.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS).
Protein: ATPB_CITBB
Sequence: MSQNFGKISQVIGAVIDVEFEPGKLPPIYQALRVTNPAIDDQEFNLVLEVAQHLGENAVRTIAMDSTDGLVRGQQVKDMGKQISVPVGKKTLGRILNVIGEPVDEMGPIGNEKEYGIHREAPLFVNQSTKVEAFTTGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIMELINNIAKQHGGFSVFAGVGERTREGNDLWMEMKESGVLDKAALVYGQMNEPPGARARVALSALSIAEYFRDEEGQDVLLFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGELQERITSTNKGSITSVQAIYVPADDLTDPAPATAFAHLDATTVLSRQIAELGIYPAVDPLDSTSRILDPQVIGDEHYAIARQVQYVLQKYKDLQDIIAILGMDELSEEDKLVVARARKIQKFLSQPFHVAEAFTGSPGKYVELKDTIKGFSEIIAGKHDDLPEQAFYMVGTIEEAIEKAQKLAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: UBP2_RAT
Sequence: MSQLSSTLKRYTESSRYTDAPYAKSGYGTYTPSSYGANLAASFLEKEKLGFKPVSPTSFLPRPRTYGPSSILDCDRGRPLLRSDITGGSKRSESQTRGNERPSGSGLNGGSGFPYGVTSNSLSYLPMNARDQGVTLGQKKSNSQSDLARDFSSLRTSDSYRTSDGYRASDGFRIDPGNLGRSPMLARTRKELCALQGLYQAASRSEYLTDYLENYGRKGSAPQVLTQAPPSRVPEVLSPTYRPSGRYTLWEKNKGQASGPSRSTSPGRDTMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAHTALMEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVAARPKPSPESLDHLPDEEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPVTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
What is the function of this protein?
Circadian clock output effector that regulates Ca(2+) absorption in the small intestine.  Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca(2+) membrane permeability mediated by the Ca(2+) channel TRPV6 in the intestine.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 2, 41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2, Ubiquitin-specific-processing protease testis, UBP-t.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, perinuclear region. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly expressed at membranes.
Protein: LPXC_COLP3
Sequence: MIKQRTLKTSVSTVGVGLHKGEKVQVTLRPAPANTGIVFRRVDLDPVVDIKASPEAVGETTLCTCLVNEQQVKVSTVEHLLSAVAGLGIDNLIIDVDSAEIPIMDGSALPFVYLIQSVGIETLNAPKRFLRIKKPIRVEEGDKWAELLPYEGFRVNFSIEFEHPVIEKTCQTMSMDFSSCSFIKEISRARTFGFMKDIEFLRSHNLALGGSLENAIVLDNYRMLNKNELRYDDEFVKHKILDAIGDLYMGSASILGELNAFKSGHGLNNLLLREVFKRTDSWEWVTYEGDKTSPIEYQEVNATAF
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: RS5_PERMH
Sequence: MGVKNIERLIEERQKIEPINPAELTLEEKVVEIRRTTRVVEGGRRFSFSTLAVVGDRNGHVGFGHGKANEVPPSIAKAIADAKKHLIRVPLIEGTIPHDVIGKYESAVVLLKPARKGTGVVAGGPVRPVLELLGVTDILTKIIGRTTNPNNTVRAVFDALLQIRSPEQVAAIRGVDEEKIRKNYRIYASAPIVK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: CRYD_SYNY3
Sequence: MKHVPPTVLVWFRNDLRLHDHEPLHRALKSGLAITAVYCYDPRQFAQTHQGFAKTGPWRSNFLQQSVQNLAESLQKVGNKLLVTTGLPEQVIPQIAKQINAKTIYYHREVTQEELDVERNLVKQLTILGIEAKGYWGSTLCHPEDLPFSIQDLPDLFTKFRKDIEKKKISIRPCFFAPSQLLPSPNIKLELTAPPPEFFPQINFDHRSVLAFQGGETAGLARLQDYFWHGDRLKDYKETRNGMVGADYSSKFSPWLALGCLSPRFIYQEVKRYEQERVSNDSTHWLIFELLWRDFFRFVAQKYGNKLFNRGGLLNKNFPWQEDQVRFELWRSGQTGYPLVDANMRELNLTGFMSNRGRQNVASFLCKNLGIDWRWGAEWFESCLIDYDVCSNWGNWNYTAGIGNDARDFRYFNIPKQSQQYDPQGTYLRHWLPELKNLPGDKIHQPWLLSATEQKQWGVQLGVDYPRPCVNFHQSVEARRKIEQMGVIA
What is the function of this protein?
May have a photoreceptor function.  Binds DNA; represses transcription of at least 8 genes, including slr0364 and slr1866.  Does not encode a DNA photolyase function.  Its disruption does not affect circadian rhythm.
What are the official names of this protein?
Cryptochrome DASH.
What is the protein family that this protein belongs to?
Belongs to the DNA photolyase class-1 family.
Protein: Y1394_BACCR
Sequence: MRIMARIGVENSLTDVQQALQQQGHEVVTLNSEQDAQGCDCCVVTGQDSNVMGIADTSIKGSVITAHGLTTDEICQQVESRT
What are the official names of this protein?
UPF0180 protein BC_1394.
What is the protein family that this protein belongs to?
Belongs to the UPF0180 family.
Protein: DEF2_MACMU
Sequence: ACYCRIPACLAGERRYGTCFYMGRVWAFCC
What is the function of this protein?
Has bacteriostatic activity against L. monocytogenes, E. coli and S. aureus, microbicidial activity against L. monocytogenes and S. aureus and antifungal activity against C. neoformans.
What are the official names of this protein?
Neutrophil defensin 2, RMAD-2.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYY_STRTD
Sequence: MTIFEELKARGLIFQTTDEEALVKAFEEGPVSFYTGYDPTADSLHLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFNDAERSLQTKETVEGWVEKIQGQLSRFLDFENGDNKAVMVNNYDWFGSVSFIDFLRDVGKYFTVNYMMSKESVKKRIETGISYTEFAYQIMQGYDFYELNAKYGVTLQIGGSDQWGNMTAGTELLRRKADKSGHVITVPLITDSTGKKFGKSEGNAVWLDATKTTPYEMYQFWLNVMDDDAVRFLKIFTFLSLEEIEEIGKEFDQARHQRLAQKVLAREVVTLVHGKEAYEQAVHITEQLFAGNLKALSARDLKVALNGVPTYEISADENLNIVELLVNAKISPSKRQAREDVQNGAIYINGERVQDLDYTLSDTDKIDNEITVIRRGKKKNFVLTY
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPA_MOUSE
Sequence: MTESTAAVTTSGHSLTTTFHIPSSQHYQEEHSPSLSGSDSLLQITTPVVASTVGNPNQHSATMSTPAIHVSTYHTAPTEVSAAFEEQPVSPHIGGMPSPIQHDFPALVMILIILGVMAGIIGTILLISYCISRMTKKSSVDIQSPEGGDNSVPLSSIEQTPNEESSNV
What is the function of this protein?
Glycophorin A is the major intrinsic membrane sialoglycoprotein of the erythrocyte.  Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1.  May be involved in translocation of SLC4A1 to the plasma membrane (By similarity).
What are the official names of this protein?
Glycophorin-A.
What is the protein family that this protein belongs to?
Belongs to the glycophorin-A family.
What are the subcellular locations of this protein?
Membrane; Single-pass type III membrane protein.
Protein: DAPE_CERS5
Sequence: MPLDPVALTADLVRCPSVTPEEGGALVLLERILTEAGFDCRRVDRNGVPNLFARWGRKGANRTFGFNGHTDVVPVGDAAAWTRDPFGGEIADGWLWGRGATDMKSGVAAFVAAAVDFVQETPPDGAVILTITGDEEGDSVDGTTALLDWMATEGEAMTVCLVGEPTCPERLGEMMKIGRRGSMTAFFTARGVQGHSAYPHRAKNPVSAMARLIDRLASHELDKGTGHFDPSTLAVTTIDTGNPATNVIPALCRATVNIRFNDRHSGASLIRWLEQEAAEVAAETGVEIGLSAKISGESFLTPPGELSELVARAVEAETGLRPEPSTSGGTSDARFVRAHCPVVEFGLVGKTMHQVDERVEVAQIEPLKAIYKRILKDYFT
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: LSPA_ACET2
Sequence: MIFIVLIAAFVAADQLTKYIVVRNIEFGDKISVIDNFFYLTHWRNTGAAWGIMQNGRYILVPVTVVLSILIVYFIFKNSNKFYRFSLSMILGGALGNLIDRVFRTDGVVDFLDFQFGNYHFPVFNVADTFVVVGTLLLAYYTLFIYKEDKK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CH60_LACPL
Sequence: MAKELKFSEDARSAMLKGVDQLADTVKSTLGPKGRNVVLEQSYGSPTITNDGVTIAKAIELDDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQSIVNEGMKNVTAGANPVGIRRGIEEATKTAVDSLHAMAHEVKTQEDIAQIASVSSASEETGKLIAEAMEKVGHDGVITIEESRGVDTSLDVVEGMQFDRGYLSQYMVTDNDKMEADLDNPYILITDKKISNIQDILPLLQSIVEQGKPLLIIADDISGEALPTLVLNKMRGTFNVVAVKAPGFGDRRKEQLQDIAILTGGTVITDDLGLELKDTTIDQLGQANKVTVTKDNTTIVEGAGSKDAISERVEFIRNQIGETTSDFDKEKLQERLAKLAGGVAVVRVGAATETELKERKYRIEDALNATRAAVEEGFVAGGGTALINVIKDVAALKETGDVQTGINIVKRALEEPVRQIAENAGLEGSVIVEKMKEQKPGVGFNAATDEWVDMIKAGIVDPTKVTRSALQNAASVSALLLTTEAVVAEKPEENAPAAPAAPNPGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MECR_XENTR
Sequence: MWLGLRLFHRPFSSLAARGLVYEKHGEPLQVLRLKNVNITHPADNEVRVKMLAAPINPSDINMVQGTYALLPQLPAVGGNEGVGVVVEIGRHVSSMRPGDWVVPVDAGLGTWCTEAVFSEDSLVRVPSDIPVAGAATVSVNPCTAYRLLSDFETLRPGDTIIQNASNSGVGQAVIQIATSLGITTINVVRDREDLSSLIQRLRDLGADHVITEEQLRKPEMKDLFKNCPRPRLALNCVGGKSTTEMLRHLDYGGTMVTYGGMSKQPVTVPVSALIFKNVKLCGFWVTQWKKERAQTDREEIVKMIRDLCDLIRRGKLVPPPSTQRPLEDFSRALQDSQTPFLSRKQILIM
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II).  Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro (By similarity).  Functions in pronephros development, regulating late differentiation of all pronephric tubule segments (PubMed:18472403).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase, mitochondrial, 2-enoyl thioester reductase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: METK_STAA1
Sequence: MLNNKRLFTSESVTEGHPDKIADQVSDAILDAILKDDPNARVACETTVTTGMALIAGEISTTTYVDIPKVVRETIKEIGYTRAKYGYDYETMAILTAIDEQSPDIAQGVDKALEYRDKDSEEEIEATGAGDQGLMFGYATNETETYMPLAIYLSHQLAKRLSDVRKDGTLNYLRPDGKVQVTVEYDENDNPVRIDTIVVSTQHADDVTLEQIQEDIKAHVIYPTVPENLINEQTKFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGCFSGKDPTKVDRSAAYAARYVAKNIVAAGLADQCEVQLAYAIGVAEPVSIAIDTFGTGKVSEGQLVEAVRKHFDLRPAGIIKMLDLKQPIYKQTAAYGHFGRTDVLFPWEKLDKVEELKDAVKY
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHO1_LEPMJ
Sequence: MPVYGSVSSPSLRKMENGYGHGQRASLSFGRIIGDPFALATISIGVLAWIIAFVSSIISAIHGGFPNFAWWTLVFMFFCIAGVTVTVASDAERTYHVAIVGFLAAGLVFTTSSVNSLVYSPIAPFEAAAAGYILLSMIAVRDCISSSLSQPATNAPRPQIVWIFYYGSQPQASHRAFVDSYALHKEHPGSRSSRPISHGYTNRPETQVASQAPQMYTSAQLNGFETSSPVSGYPGGPAGANGRNSSVPQFGGMPNNGIPNAATPTQDEAHQQEASIEYPYRAKAIYSYEANPDDANEISFQKHDVLEVSDVSGRWWQAKKPNGETGIAPSNYLILL
What is the function of this protein?
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
What are the official names of this protein?
High osmolarity signaling protein SHO1, Osmosensor SHO1.
What is the protein family that this protein belongs to?
Belongs to the SHO1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROC_SYNSC
Sequence: MGSSFGDLFRISTFGESHGGGVGVIVEGCPPRLNLSVESIQAELDRRKPGQSHITTPRKEADQVQVLSGLLDGETTLGTPIAMVVRNKDQRPGDYKDMAVAFRPSHADATYQAKYGIQARSGGGRASARETIGRVAAGAIAKQLLKQAAGTEILAWVKRIHNIEASGIDPQRVQLSDVEANIVRCPESAVAERMVERIEAIGREGDSCGGVIECVVRHPAVGLGMPVFDKLEADLAKAVMSLPATKGFEIGSGFDGTLLKGSEHNDAFLPSDDGRLKTATNNSGGIQGGISNGEPIVIRVAFKPTATIRKEQQTIDSDGKATTLAGKGRHDPCVLPRAVPMVEAMVALVLADHLLRQQGQCSLW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: GLMM_PSEPG
Sequence: MSRKYFGTDGIRGRVGEYPITPDFMLKLGWAAGMAFRKQGHCRVLVGKDTRISGYMFESALEAGLAAAGADVMLLGPMPTPAIAYLTRTFHAQAGIVISASHNPHEDNGIKFFSGQGTKLPDEVELMIEELLDQPMTVVDSSKLGKVSRINDAAGRYIEFCKSSVPSSTSFDGLKLVVDCAHGATYKVAPSVFRELGADVTVLHAQPDGLNINEGCGSTHIESLQAAVLVGHADLGIAFDGDGDRVLMVDHTGAIVDGDELLFIIARDLHDRGKLQGGVVGTLMSNLGLELALKDLDIPFVRAKVGDRYVMAELLEREWLVGGENSGHVVCCNHTTTGDAIIAALQVLMALKRRGETLAQARQALRKCPQVLINVRFGASKVDPLEHPAVKDASAKVTEALAGRGRVLLRKSGTEPLVRVMVEGEDETQVRGHAEALAKLVGEVCV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: Y708_STAAW
Sequence: MFEAFIYNISVIVAGIYLFHRLQYSENKRMVFSKAYVTVLMTIVSLLLSVYPIPYREDYLIHLTFVPLLFLGRFTNMVYTLSATVIVAIVEIVVFNNSIMYGVTLIVIAAVTSAIGPFLKQNDVLSLLILNVVTIIILFGVALVSPIYTLSEVIILIPISLIITLASAITFVDIWHFFSLVNRYENEDKYDYLTGLGNVKEFDRHLNEISRKAEKEHQSIALLLIDIDGFKDVNDTYSHKSGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIHNYSLDQSVKLAENIRSGVEKSSFHLPNKEVIKLSVSIGVGYLTDDDPKSQRKVFKDADDMVHVAKNQGRNKVMFNPIINL
What are the official names of this protein?
Uncharacterized membrane protein MW0708.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MTAP_DROPS
Sequence: MLHIKCKDTDLDPIPVKIGIIGGSGLDDPDILENRQEKVISTPYGEPSDALIQGEIGGVQCVLLARHGRKHDIMPSNVNYRANIWALRDVGCTHLIVSTACGSLREQIKPGNLVMPHDFIDRTTKRSQTFYDGSATSPRGVCHLPMYPAFSERTRNILIEAAKELEIPAHEKATIVTIEGPRFSSRSESLMFREWGGDLINMTTCPEVVLAKEAGLLYGSVAIATDYDCWRMGCEGVNVQDVLKTFAENVIKVKKILVNAVGRIAKEDWSEDILNAKQCVCNNTMSGAM
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP, MTAPase.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YLAT2_RAT
Sequence: MEARELGSPTPTYHLLPKANQHTVKEDASSPSQGSPETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLKYTASYGLSLVVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLIVEPTSQAIIAITFANYIIKPSFPTCDPPYVACRLLAAACVCLLTFVNCAYVKWGTRVQDTFTYAKVLALIAIIIMGLVKLCQGHTEHFQDAFKGSSWNVGDLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNIQDVHKSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPNLLSMIHIERFTPVPALLFNCTMTLIYLVVKDVFLLINYFSFSYWFFVGLSVVGQLYLRWKEPDWPRPLKLSLFFPIVFCICSLFLVAVPLFSDTINSLIGIGIALSGVPVYFMGVYLPEARRPLFIRKVLATVTRVTQKLCFCVLTELDVAEEKNVERKTD
What is the function of this protein?
Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux routeby exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:26448619, PubMed:22401943).  Also exchanges L-arginine with L-lysine in a sodium-independent manner.  The transport mechanism is electroneutral and operates with a stoichiometry of 1: 1 (By similarity).  Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (PubMed:26448619, PubMed:22401943).  May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (By similarity).  May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity).
What are the official names of this protein?
Y+L amino acid transporter 2, Solute carrier family 7 member 6, y(+)L-type amino acid transporter 2, Y+LAT2, y+LAT-2.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.