PharMolix/UniProtQA huggingface dataset:
Protein: TRPB_ACTPJ
Sequence: MSDTLLNPYFGEFGGMYVPEILVPVLKQLEETFVAAQNDPLFQAEFTDLLKNYAGRPTALTLCRNLTKGSKTKLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTRIIAETGAGQHGVATALACAMLDLPCVIYMGAKDVERQSPNVFRMRLMGAEVIPVQKGSCSLKDACCEAMRDWAANYETTHYLIGTAAGPHPFPTMVREFQKMIGEETKRQILEKENRLPDAVIAAVGGGSNAIGMFAGFIEEKSVQLIGVEPAGKGIETGEHGAPLKHGTTGIYFGMKSPIMQTKDGQIEESYSISAGLDFPSVGPQHAYLNSIGRAEYVSITNQEALDAFQALAQHEGIIPALESSHALAYALKLIAQNPDKEQLLVVNLSGRGDKDIFTVDKILNGGN
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: AGNO_POVS1
Sequence: MVLRQLSRQASVKVGKTWTGTKRRAQRIFIFILELLLDFCRGEDSVDGKKKKDSLTDKTETVTEKKES
What is the function of this protein?
Alters the structure of the nuclear envelope by interacting with host CBX5 and disrupting CBX5 association with LBR.  Involved in the perinuclear-nuclear localization of the capsid protein VP1 during virion assembly and maturation.  Plays an important role in the release of progeny virions from infected cells and in viral propagation, probably by acting as a viral ionic channel in the host plasma membrane.  Allows influx of extracellular calcium ions in the host cell.  May contribute to viral genome transcription and translation of viral late proteins (By similarity).
What are the official names of this protein?
Agnoprotein, Agno.
What is the protein family that this protein belongs to?
Belongs to the polyomavirus agnoprotein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus membrane; Single-pass type II membrane protein. Host rough endoplasmic reticulum membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. Note=Mostly perinuclear.
Protein: UD19_MOUSE
Sequence: MAPVAFPTSFFLCLLLASGLAQAGRLLVVPMDGSHWFTMQMVVEKLIHRGHEVVVVIPEVSWQLGKSLNCTVKTYSISHTLEDLDREFKYLSYTQWKTPEHSIRSFLTGSARGFFELTFSHCRSLFNDKKLVEYLKQRFFDAVFLDPFDVCGLIVAKYFSLPSVIFARGVFCDYLEEGAQCPSLPSYVPRLFSKYTDTMTFKERVWNHLIYIEEHAFCSYFLRTAVEVASEILQTPVTMTDLFSPVSIWLLRTDFVLEFPRPVMPNMVFIGGINCLQKKSLSKEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH
What is the function of this protein?
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile.  Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds.  Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone.  Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties.  Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II.  Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan.  Also metabolizes mycophenolic acid, an immunosuppressive agent.
What are the official names of this protein?
UDP-glucuronosyltransferase 1A9, UGT1A9, UDP-glucuronosyltransferase 1-7, UDPGT, UDP-glucuronosyltransferase 1-9, UDPGT 1-9, UGT1*9, UGT1-09, UGT1.9, UGT1A12, UGTP4.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RL31_IDILO
Sequence: MKQGIHPKYETLKVSCSCGHTFETRSTRSEDLHLDVCSECHPFYTGKQRVMDTGGRVDKFKKRFGALGKKDS
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: CBSA_SACS2
Sequence: MLKPFCEKMSIKRKSKYTLGVLLLASFLAIIMGLANVPMAQTSPQIPVYKVVGNADLSNPGSASYWSQIPWINISLTANIPMAPTSGLTHYLLVKAVWNGSWIIILERWYAPEPAFGAWSAAAAALYPPASGPGLFRQIMLTPGTTYTIEKNYTNYFSIVNGNIIQGRLVLNYSGILLPAPNDTQITVLSNGTIILWHSPRPIEDLLYSDGMFYGYYTNNTWYYPDRAAIMWYMGSVIPPTKDGMNIGGKVPGQAFDGVTFNDTGGSLVQPGGAANIWMWVSGATWNNATYDPAFKVNLWQNTSLTGLPYIDPDNHGFAVPLYTNNTNMYEVDTAGIWYTPVTTSGLNGSLFFIWTGATYQNGYWTVEFARPLAVPSAYAKWMPNITVGKTYYVAFAVWQGKLGETLFDKSITSNFLTLELVTTPPTSTTTSTISSTSVTTTTSITTVTSIPSTTIYVTIVGVVIAIIALIILYVVFRR
What is the function of this protein?
Monoheme cytochrome whose physiological function is not yet clear.
What are the official names of this protein?
Cytochrome b558/566 subunit A.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YFEO_SALHS
Sequence: MFHPRARTMLLLSLPALIIGVASSLVLIAAMKVASVFQQFLWQRLPTSIGIAYDSPFWIVGMLTLTGIVVGLIIRYSPGHAGPDPAIEPLISMPVSPSALPGLLLALIIGLAGGVSLGPEHPIMTINIALAAAFGSRLFPRITALDWTILASAGTIGALFGTPVAAALIFSQTLSGSNDIPMWDRLFAPLMAAAAGSLTTSLFFHPHFSLPIAHYTQMRLVDIASGAIVAAIAIAAGMVAVWCLPRLHELLHRLKNPVLILGIGGFILGILGVIGGPLTLFKGLDEMQQMAFSQTLGAGDYFTLAVVKLAALVIAAASGFRGGRIFPAVFIGAALGLMLHAHVEAVPAAITVSCAILGLVLVVTRDGWLSLFMAAVVVPDTNLLPLLCIVMLPAWLLLAGKPLLAANRHEP
What are the official names of this protein?
Putative ion-transport protein YfeO.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPIA_HALSA
Sequence: MKQAGGSAEQKRRAGEAAVAEEVTEGAVVGLGTGSTVAHAIRALGAEASDVSGVATSFESRRRAVDAGVTVTSLEAASVDVAIDGADQVADGVLVKGGGAAHTREKYVAASADRFVVVADPSKESDVVDVPVPVAVVPDAWPVVVDRVEALGGTATLRDAERKDGPVVTDTGSLVVDCDFGAIETPEAVAASLSAVPGVVEHGLFVGMADAVYVGTDDGVRVRDP
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: FEV_MOUSE
Sequence: MRQSGTSQPLLINMYLPDPVGDGLFKEGKSPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPNATAAAAATAALYPTPGLQPPPGPFGAVAAASHLGGHYH
What is the function of this protein?
Functions as a transcriptional regulator.  May function as a transcriptional repressor.  Functions in the differentiation and the maintenance of the central serotonergic neurons.  May play a role in cell growth.
What are the official names of this protein?
Protein FEV, PC12 ETS domain-containing transcription factor 1, PC12 ETS factor 1, Pet-1, mPet-1.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ENY2B_DROME
Sequence: MTINKETGTDPDPGYKPTLRSQDKAALKELLHTRLVECGWHKDIKEMIRNIIMERGVDNINRDQLAAQIVPQARALVPEVVKNEMMLRVHAALDK
What is the function of this protein?
Testis-specific paralog of the ubiquitously expressed transcription and mRNA export factor e(y)2.  Cannot functionally replace e(y)2.
What are the official names of this protein?
Enhancer of yellow 2b transcription factor, Testis-specific e(y)2 paralog.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
Protein: GLMM_RHOPB
Sequence: MSRRYFGTDGIRGRANGLITPELAMKVGQAAGLVFQRGEYRHRVVIGKDTRLSGYMIETALVAGFTSVGMDVLLLGPMPTPAVAMLTKSMRADLGVMISASHNLFEDNGIKLFGPLGFKLSDDVEKQIEQLLDESLDKKLAESASLGRARRIDGVHDRYIEFAKRTLPRDLSLDGLRVVIDCAHGAAYKVVPEALWELGADVIAIGVEPDGFNINKECGSTAPEALSRKVREMRADIGIALDGDADRVILVDERGHVVDGDQLLAVIAQSWKEDGRLSKPGIVATVMSNLGLERFLQSNGIEMVRTPVGDRYVLEQMLKQGYNVGGEPSGHIILSDYATTGDGFVAALQVLAVVQKLGRPVSEVCHLFEPLPQVLKNVRYRAGKPLEDDEVKSAIHAAEKRLNGHGRLLVRSSGTEPVIRVMGEGDDREMVEEVVDTICSALGEAAAAAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: PP1_PHAVU
Sequence: MDKAVLDDVIRRLLEGKGGKQVQLSESEIRQLCVHARQIFLSQPILLELRAPMRVCGDIHGQYQDLLRLFEYGGYPPAANYLFLGDYVDRGKQSLETICLLLAYKIRYPDKIFLLRGNHEEAKINRIYGFYDECKRRFNVRLWKIFTDCFNCLPVSALIDDKILCMHGGLSPELESLDQIKEIQRPTEIPDSGLLCDLLWSDPDSSIEGWAESDRGVSCTFGPDVVAEFLDKNDLDLVCRGHQVVEDGYEFFAKRRLVTIFSAPNYGGEFDNAGALLSVDDSLVCSFEILKPADRASGSSSKMNFKKPPKMGKI
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
Protein: SYFA_LACLA
Sequence: MNLQEKIEDLRKRTLSDLLSVADEKTLNNLRTVMLGKKGELTEILKGMKDLTNEERPVIGALANAFRDEFGAKFEAKKVEIEQAVMNAALESETLDVTLPGKAQKKGSRHILTQTQEEIEEIFLGMGYEIVDGYEVETDHYNFERMNLPKDHPARDMQDTFYITNEVLLRTHTSPMQARTMDAHDFSKGGLRMIAPGRVYRRDTDDATHSHQFHQIEGLVVDKNITMADLKGTLDLVMKKMFGQDRELRWRPSYFPFTEPSVEVDISCFKCGGKGCNVCKHTGWIEILGAGMVHPNVLEMSGLDSSVYSGFAFGLGQERIAMLRYGINDIRGFYQGDVRFLEQFGK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_BURMS
Sequence: MKIGHQFHTVALVGRSNTPGIAEPLASLAACIAKRGFEVVFEADTAQAIGSAGYPALTPAEIGARAGVAVVLGGDGTMLGMGRQLAPYKTPLIGINHGRLGFITDIPASDMREVVPMMLAGSYEREERTLLEARIVRNGEPIYHALAFNDVVVNRSGFSGMAELRVSVDGRFMYNQRSDGLIVATPTGSTAYALSSQGPILHPQLQGIVLVPIAPHALSNRPIVLPDDSKIAIQIIGGRDVNVNFDMQSFTALELNDTIEVRRSKHTVPFLHPVGYSYYATLRKKLHWNEHPSSEEDDDA
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMHA_RHORT
Sequence: MEDEIRAFCQTAADCFIRLGDCAPAIAEAAGVVTASLRAGGKVMFCGNGGSAADAQHLAAELEGRYLKERAPLPGMALTTNTSTLTAVGNDYGFDHIFSRQVSAHGRPGDVLVALSTSGNSANVLKAIEAAREKGVSVIGLTGAGGGKMAEVCDLCIRVPSTQTPQIQQMHIAVGHLLCGLVEDALCS
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATE_THEP3
Sequence: MQGIAKIKEKIFEEATEQKNRIIEKAKKEAAEILEKARKQAVQLEAEAEKKAKKVAREEKRKILSIAELEERKRYLEAKQALINEAFVRAENKLLNLEPEKYRDLVYRMILAAAVDGNEEIIVSEADKEKITPELLERVNEALKKQGKAGNIRFSGEKRAIKGGFILKSATVEINCTFDYLLKVQREELETEVARILFEE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type proton ATPase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: OPS4_DROME
Sequence: MEPLCNASEPPLRPEARSSGNGDLQFLGWNVPPDQIQYIPEHWLTQLEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLKAPIFIYNSFHRGFALGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNRNMTFTKAVIMNIIIWLYCTPWVVLPLTQFWDRFVPEGYLTSCSFDYLSDNFDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKALREQAKKMNVESLRSNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGAFGDKSLLTPGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWLGVNEKSGEISSAQSTTTQEQQQTTAA
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.
What are the official names of this protein?
Opsin Rh4, Inner R7 photoreceptor cells opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS29_ASHGO
Sequence: MAHENVWFSHPRNYGKGSRQCRVCASHSGLIRKYGLNICRQCFREKANDIGFHKYR
What are the official names of this protein?
40S ribosomal protein S29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RL2_PECCP
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPYAPLLEKNSKSGGRNNNGRITTRHIGGGHKQQYRLIDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKAGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGSYVTLRLRSGEMRKVESDCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVSPWGLQTKGKKTRSNKRTDKFIVRRRTK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DX39B_MOUSE
Sequence: MAENDVDNELLDYEDDEVETAAGADGTEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR
What is the function of this protein?
Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint.  Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity.  Even with the stimulation of RNA, the ATPase activity is weak.  Can only hydrolyze ATP but not other NTPs.  The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA.  However, ssRNA stimulates the ATPase activity much more strongly than dsRNA.  Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro.  The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [] reporting a stimulatory effect.
What are the official names of this protein?
Spliceosome RNA helicase Ddx39b, 56 kDa U2AF65-associated protein, DEAD box protein UAP56, HLA-B-associated transcript 1 protein.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1.
Protein: SYC_BURMA
Sequence: MESLRIYNTLARDKQDFVPRQPGEVRMYVCGITVYDYCHIGHARMVVVFDIVQRWLRARGYRVTYVRNITDIDDKIIRRAVENGETIQSLTRRFTDAMNADFDALGVERPDLEPRATEFIPQMLGMIEKLEANGYAYQAKDGDVNYSVRKFANYGRLSGKSLEDLRAGERVAANDAKEDPLDFVLWKRAKPQEPAGASWESKYGAGRPGWHIECSAMGCTLLGAHFDIHGGGQDLQFPHHENEIAQSEGATGQTFVNYWMHNGFVQVDSEKMSKSLGNFFTIREVLEKFDAEVVRFFIVRTHYRSPLNYSDVHLDDARASLTRLYTALKDATPDAQPLDWSEAHAQRFAAAMNDDFNTAVAVAVLFELATEVNRTREPALARQLRLLAGLLGLLGREPREFLQHAAGAARTGALEPHEIEARIAARVAAKQAKNYAEADRIRAELLEAGIALEDKPGGSTEWRRV
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YO150_YEAST
Sequence: MIKNNCNNVNIYKYYLFSFKVYILPSNFKIWEAVSSMVSFKFLNLKPNNFLLFLLSRVAPRVLWVAPEPGFPTGILPFRTGKSSLRISRTSCIVNLASDTISL
What are the official names of this protein?
Putative uncharacterized protein YOL150C.
Protein: COX1_SORBI
Sequence: MTNLVRWLFSTNHKDIGTLYFIFGAIAGVMGTCFSVLIRMELARPGDQILGGNHQLYNVLITAHAFLMIFFMVMPAMIGGFGNWFVPILIGAPDMAFPRLNNISFWLLPPSLLLLLSSALVEVGSGTGWTVYPPLSGITSHSGGAVDLAIFSLHLSGVSSILGSINFITTIFNMRGPGMTMHRLPLFVWSVLVTAFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVSTFSRKPVFGYLGMVYAMISIGVLGFLVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKIFSWIATMWGGSIQYKTPMLFAVGFIFLFTIGGLTGIVLANSGLDIALHDTYYVVAHFHYVLSMGAVFALFAGFYYWVGKIFGRTYPETLGQIHFWITFFGVNLTFFPMHFLGLSGMPRRIPDYPDAYAGWNALSSFGSYISVVGIRRFFVVVAITSSSGKNKRCAESPWAVEQNPTTLEWLVQSPPAFHTFGELPTIKETQGELQTRK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CP1A1_RABIT
Sequence: MVSDFGLPTFISATELLLASAVFCLVFWVAGASKPRVPKGLKRLPGPWGWPLLGHVLTLGKNPHVALARLSRRYGDVFQIRLGSTPVVVLSGLDTIKQALVRQGDDFKGRPDLYSFSFVTKGQSMIFGSDSGPVWAARRRLAQNALNSFSVASDPASSSSCYLEEHVSQEAENLISKFQELMAAVGHFDPYRYVVMSVANVICAMCFGRRYDHDDQELLSLVNLNDEFGKVAASGSPADFFLILRYLPNPALDTFKDLNERFYSFTQERVKEHCRSFEKGHIRDITDSLIKHYRVDRLDENANVQVSDEKTVGIVLDLFGAGFDTVTTAISWSLMYLVTKPRIQRKIQEELDAVVGRARRPRFSDRPQLPYLEAVIMETFRHTSFLPFTIPHSTTRDTSLGGFYIPKGRCVFVNQWQNNHDPELWGDPEAFRPERFLTPSGAVDKALTEKVLLFGLGKRKCIGETIGRLEVFLFLATLLQQVEFSVSPGTTVDMTPIYGLTMKHARCEHFQAKLRFEA
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions.  Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation.  Catalyzes the epoxidation of double bonds of certain PUFA.  Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system.  Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer.  May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues.  Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid.  May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).
What are the official names of this protein?
Cytochrome P450 1A1, CYPIA1, Cytochrome P-450 PHPAH1, Cytochrome P450 isozyme 6, Cytochrome P450 LM6, Cytochrome P450-C, Cytochrome P450-P1, Hydroperoxy icosatetraenoate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Cytoplasm.
Protein: SBT4D_ARATH
Sequence: MATLAASSSLLSCLLVLFLSSVSAVTDDKQVYIVYMGSLSSRADYTPTSDHMNILQEVTGESSIEGRLVRSYKRSFNGFAARLTESERERVAKMVGVVSVFPNKKLQLQTTTSWDFMGLKEGIKTKRNPTVESDTIIGVIDSGITPESQSFSDKGFGPPPQKWKGVCSGGKNFTCNNKLIGARDYTSEGTRDMDGHGTHTASTAAGNAVVDASFFGIGNGTVRGGVPASRVAAYKVCTPTGCSSEALLSAFDDAIADGVDLITISIGDKTASMFQNDPIAIGAFHAMAKGVLTVNSAGNSGPKPISVSGVAPWILTVAASTTNRGFVTKVVLGNGKTLVGKSVNAYEMKGKDYPLVYGKSAASSACDAESAGLCELSCVDKSRVKGKILVCGGPGGLKIVESVGAVGLIYRTPKPDVAFIHPLPAAGLLTEDFESLVSYLESTDSPQAIVLKTEAIFNRTSPVIASFSSRGPNTIAVDILKPDITAPGVEILAAYSPAGEPSQDDTRHVKYSVLSGTSMSCPHVAGVAAYVKTFNPKWSPSMIQSAIMTTAWPVNATGTGIASTEFAYGSGHVDPIAASNPGLVYELDKSDHIAFLCGMNYTSQVLKVISGETVTCSEAKKILPRNLNYPSMSAKLSGSGTTFTVTFNRTLTNVGTPNSTYTSKVVAGHGSKLDVKITPSVLSFKTVNEKQSFTVTVTGSNLDSEVPSSANLIWSDGTHNVRSPIVVYTSDY
What are the official names of this protein?
Subtilisin-like protease SBT4.13, Subtilase subfamily 4 member 13, AtSBT4.13.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CACB1_BOVIN
Sequence: MVQKTSMSRGPYPSSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNRLSSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQGPYLASGDQSLERATGEHASVHEYPGELGQPPGLYPSSHPPGRAGTLRALSRQDTFDADTPGNRNSAYTELGDSCVDMETDPSEGPGLGDPAGGSTPPARQGSWEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR
What is the function of this protein?
Regulatory subunit of L-type calcium channels (PubMed:10684870).  Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity).  Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane.  Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (By similarity).  Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:10684870).
What are the official names of this protein?
Voltage-dependent L-type calcium channel subunit beta-1, CAB1, Calcium channel voltage-dependent subunit beta 1.
What is the protein family that this protein belongs to?
Belongs to the calcium channel beta subunit family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein.