PharMolix/UniProtQA huggingface dataset:
Protein: AMPL_DICDI
Sequence: MLKNIINKKNLFINNQQNIFQIIKRNKMTDSTVDNKGYIVGIYENEEFTPLGQQLNEKTNGHLLKSIKLSDTKGKVGDNLVLYNVTPEVSRVAIVGLGKKENNNSTTYEKNENTRKAIGSGVKALKSKNATHLTIDSNIGDAKQTAEGAFLSNFKFDFKTGTSGKTANSTNESIQVQLSPSPSSEECFKEGKILAESQNFARVLMETPANLLTPTNFVQHVSSQMKELIDSGKVEMIVREEQWVKDQKMGMFWGVAKGSDEPLKFLELHYRGASADGKDSIVYVGKGITFDSGGISIKPSANMGLMKGDMGGAATAVSAMFGVASLGLKVNLITITPLCENMPSGKATKPGDILTAANGKTVEVDNTDAEGRLILGDALHYACSFKPTHIIDIATLTGAIDVALGQHYAGCFTTTDSLWDQLNECGNISGERLWRMPLIPEYRKQMETSKVADLINSAGRSGGACCAAGFLKEFITADQSWSHLDIAGVMSSSEDGPYIRKGMTGKPTRTLIEFAKKNQQ
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).
What are the official names of this protein?
Cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase, Proline aminopeptidase, Prolyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACBD6_XENLA
Sequence: MASPGILEESSSGDVCSGGCPDQWEEKTEEELQCQFEQAAKHVQNVASVASTEQLLYLYARYKQVKVGRCNTPKPGFFDYEGKKKWEAWKALGDYSHQQAMTEYIETVKKLDPDWSPQALEEPYKEPKTTFGGPVVSCLYKVQETLREEDKDIFDYCRENNHSRVSHALSTGSVDVNVADDEGRSLLHWACDRGHTQLVSVILFHNAHINMQDSEGQTPLHYASACEFPDIVDLLLDHGADPSLVDNDGFQPHEVTDSKTIAAMLQQHASNGEHNKPPSLLLEMPQ
What is the function of this protein?
Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA.  Does not bind fatty acids (By similarity).
What are the official names of this protein?
Acyl-CoA-binding domain-containing protein 6.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_STRSV
Sequence: MAYRKLGRTSSQRKAMLRDLTTDLLINESIVTTEARAKEIRKTVEKMITLGKRGDLHARRQAAAFVRNEIASENYDEATEKYTTTTALQKLFSEIAPRYAERNGGYTRILKTEPRRGDAAPMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: IF2_CHLTR
Sequence: MEKVKLTKNLKLKIKNAQLTKAAGLDKLKQKLAQAGSSDTKNSPASKAQTKEKSSKKTAGTPAPAPEVDSGATESTARRIRAKDRSSFAAEPTVTTALPGDASHLTLDAIPAMKAPEITSVTQKEQTLGECTDTSSVQQEEKKESSEETSPERVEETLIIRTRTEPKSVVSIKPKFGPTGKHINHLLAKTFKAPAKETKAASTEETTQQQPRQNDAASYNNKQQPSGTSSRPASSAPSYRRESTNNNNNAKRGSERDRSKRSDESVKAFTGRDRYGLNEGSSEEDKWRKKRVHKTKKQAEEHVVQCPAHIKIALPITVKDLAAEMKLKASELIQKLFIHGMTYVVNDVLDSQTVVEYIGLEFGCTIEIDSSAKEKLCLLENAVRDEVNATDPEKLIIRSPIVAFMGHVDHGKTTIIDALRQSNMAASEAGAITQHTGAFKCTTPVGEITVLDTPGHEAFSAMRARGAEVCDIVVLVVAGDEGIKEQTIEAIEHAKGANITIVVAINKCDKPNFNVETVYRQLAELDLLPEAWGGSIATINTSAKTGEGLQDLLEMLALQAEVLELKADPSARARGLVIESELHKGLGAVATVLVQNGTLHLGEALVFNDCYGKVKTMHDEHNQLLQSATPSTPVLITGLSAIPKAGDPFIVVKNEKVAKEIISARLAGQQRSAALQKKRPNFDAVLQNKKTLKLIIKADVQGSIEALAHSILNIRSEKVDVEILSSEVGDISESDIRLASASKATVIGFHTSVESHAEPLIKNLNVKVCLFDIIYHAVDAIKEIMTGLLDPIAEEKNLGAAEIKATFKSSQLGTIYGCLVTEGTIVRNQKIRIIRDKEVLWKGSLSSLKRLKEDVKEVKKGMECGILLDNYQQAQVGDILQCYEVIYHPQKL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_VIBC1
Sequence: MQGSVTEFLKPRLVDIEQISSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVIEVEIEGVLHEYSTKEGVQEDILEILLNLKGLAVRVAEGKDEVFITLNKSGSGPVVAGDITHDGDVEIANPEHVICHLTDDNAEIAMRIKVERGRGYVPASARIHNEEDERPIGRLLVDATYSPVDKIAYAVEAARVEQRTDLDKLVIDMETNGTLEPEEAIRRAATILAEQLDAFVDLRDVRVPEEKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIAED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: DAPE_WOLPM
Sequence: MKIDPVELTRKLISFESITPEDSGAIEYIATIFKKSGFDCEILEFGDKVKNLYAKYINGVPNLCFAGHVDVVPPGQLKDWAFGPFKPEVRDGMLYGRGAADMKSGVAAFIAAMVNLIAEKFQFNGSISALITSAEESMEEYGTKAVLEWMKNKQKKIDFCVVGEPTSSEKLGDTIKIGRRGSVTFELICHGKQGHVAYPDLADNPIYKVISILSKVKNTTFDHGNKYFQPSHCEVTTIDVGNNTSNLIPGSATTRFNIRYNNEQTPGGLYKLIDEICSSVTNDYKLSMHSSRDVFLSTPDRNTDIMLDAISKVTNIDAILSTSGGTSDAAFIKDVCPVIEFGIINKTAHQINECVSVNDIHKLTAIYKEFIENYFNPTNKILNQVNVVSNISSGPLLA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: GALS2_ARATH
Sequence: MAKERDQNTKDKNLLICFLWNFSAELKLALMALLVLCTLATLLPFLPSSFSISASELRFCISRIAVNSTSVNFTTVVEKPVLDNAVKLTEKPVLDNGVTKQPLTEEKVLNNGVIKRTFTGYGWAAYNFVLMNAYRGGVNTFAVIGLSSKPLHVYSHPTYRCEWIPLNQSDNRILTDGTKILTDWGYGRVYTTVVVNCTFPSNTVINPKNTGGTLLLHATTGDTDRNITDSIPVLTETPNTVDFALYESNLRRREKYDYLYCGSSLYGNLSPQRIREWIAYHVRFFGERSHFVLHDAGGITEEVFEVLKPWIELGRVTVHDIREQERFDGYYHNQFMVVNDCLHRYRFMAKWMFFFDVDEFIYVPAKSSISSVMVSLEEYSQFTIEQMPMSSQLCYDGDGPARTYRKWGFEKLAYRDVKKVPRRDRKYAVQPRNVFATGVHMSQHLQGKTYHRAEGKIRYFHYHGSISQRREPCRHLYNGTRIVHENNPYVLDTTMRDIGLAVKTFEIRTIGDRLLRTRQ
What is the function of this protein?
Involved in the biosynthesis of beta-1,4-galactan.  Beta-1,4-galactans are abundant polysaccharides in plant cell walls and are found as side-chain of rhamnogalacturonan I, which is a major component of pectin.
What are the official names of this protein?
Galactan beta-1,4-galactosyltransferase GALS2, Beta-1,4-galactan synthase, Galactan synthase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 92 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass membrane protein.
Protein: DUT_CANGA
Sequence: MSGNVLKVQLRSEHGIAPTKGSVYAAGYDIYASADYVIPAMGQGMVPTDISFTVPEGTYGRIAPRSGLAVKHGIQTGAGVVDRDYTGEVKIILFNHSQKDFEIKRGDRVAQLILEKIVDDAEVVVVESLEDSQRGAGGFGSTGK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: EFC13_HUMAN
Sequence: METKVHLFCQAEENIDLLDDGSNSFATDLSSGTINHKKYIKFSKTIEKEISPEIRSLSPEYKKIFETSIIFCGEEKSSDFSGEKKVGRKSLQVQQHSKRTEIIPPFLKLSKEKVTRKENSLCKLPNQYSVHKTSSPLCTSSAITREKEMLSNLYMTLYDEVTHGYLHSKELSALHKACKIFSKIRSGKIYVNDLPVILCILRISISDLEMRQALKTVDIDAFQDALKIFCRIKGGRVSTDDVFAVLDSMGIPINREILEEVTKHTYIDSNHMVDIGDIIFTLNELQEQYEDVSITEGSPLNEITSDRKLSSVAGCYLKYKKKNSLSSKLPEPSISKKLNKKSNQYYSKIMENDDLESKRPKNTWQIRKFLGGVGSSNVGVQEPYSKNGINFKKHSEKGEIHDSKSKPQSLKSSTSLSKSLDKSDISSIPKLQKPAVRKHSSLQKQVSSTEKTAISTLENFCEAISKLQENYIAAEELQSILPSTGINLLDEEFQKIVTDTSRNENGMVELDDFVNALAKERSFPECNALPGVIKAIDKIKDKNVDYEDLNTCLQNFGIYLSKPEFKKITELTEAGETKKVNFKEFIDTMMSNTECFSEKLVLPDAIETLDDLRKETMSVSDLWNTLSSLNSNLKKDEFLAALELVTVDEGDKVQFEEFAKVVRNMRDAARLEELQEVVLAADLLEGDMIAGKNLEDFLRNVGIKSPKEEVEKILQSDFVSEDNMVNIKDCMRALRDTQKFSNYIDFRKEASNLKLPKVNEIKEAANILSHVDNGKIGIPDLEHALKCLNVNLTEEDFNEALNCCNVSDNMEVDLKDFLMKMKESPHFQKSKATQILLATTQILQNDLVDVSDLKTLLMDKDLHTANAILTVMLRHVPEHESGKVSIQEFMTKLSDILTIPKAAGKFYLICTYCPDLERQAVVYMLKTIQDSIVKAQVSKKQYNMNIKQHKISLHNFCLNSKANIAKLNPNSKF
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 13.
Protein: CAP2_DICDI
Sequence: MYNPPPPSGSQGNNNYYRQPSSTPGVSNPNPQANQFLPPPPSNTQAPRPGFPPSAPPPSAPAGQYSMPPPPQQQQQAGQYGMPPPPSGSGIGTGVSLVKDQQISLSKEDPYLRKLTVGLGWDVNTTPSAPFDLDAVVFMLGANGMVRQPADFIFYNNKQSRDGSIFHHGDNLTGAGDGDDEVVSVNLQAVSPDVTRLVFAVTIHQPELRRQNFGMVPRAFIRIANQETTRNICRYDLTNEGGTNTAMIVGEVYRDPQNPQNWSFIAVGKSFPGGLQFLCQIFGVNAS
What are the official names of this protein?
cAMP-binding protein 2, CABP-2, CABP1-related protein p31/p34.
What is the protein family that this protein belongs to?
Belongs to the CAPAB/TerDEXZ family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL27_METS4
Sequence: MAHKKAGGSSRNGRDSEGRRLGVKKFGNEAVIAGNIIVRQRGTRWHPGTNVGIGRDHTLFALTDGRVQFATKQGRAYVTVVPAQDAPAREAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: YIDD_CLOK1
Sequence: MKKFLIFLIKVYRKYISPLKVPCCRFYPTCSQYVLEALQKHGIIKGGFMSIKRILRCNPFCKGGYDPVK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LONF3_MACFA
Sequence: MESLRTEQMLSLPAEVSSNNLEPAERGASAAQVDMGPHREAAAESPAPLPTREPEQEQSPGTSTPESKVLLTQADALASRGRIREALEVYRQLSERQQLVAEQLEQLVRCLAEKVPQGEALAPAPPGEGSTASGAVAAEETGAAAAAAATEVWDGFKCRKCHGFLSDPVSLSCGHTFCKLCLERGRAADRRCALCGVKLSALMVATGRARGSRRAGQQPPPPLRVNVVLSGLLGKLFPGPARASQLRHEGNRLYRERQVEAALLKYNEAVKLAPNDHLLYSNRSQIYFTLESHENALHDAEIACKLRPMGFKDNLELPHCSSQEEAAARGDGSSLMDPAKVKGDGQQHHMKDQEEEEEKWDATSPKAASSKTGKCQEKKRKHCQIESQEDTGMPNKASKQDPPTDQGDKPALSLPLASFDASDLECALCMRLFYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDGLSQCLASRKYSKNVIMEELIAKFLPEELKERRKLYEEEMEELSNLNKNVPIFVCTMAYPTVPCPLHIFEPCYRLMIRRCIETGTRQFGMCLGDPVKGFAEYGCILEIRNVQFFADGRSVVDSIGKRRFRVLHQSQRDGYNTADIEYIEDQKVQGEDCAELMGLHNCVYQQASLWFHSLKSSLKNRILNHFGPMPEKDADPQMNPNGPAWCWWMLAVLPLESRAQLPFLAMRSLKDRLNGIRRVLAFISRNQN
What are the official names of this protein?
LON peptidase N-terminal domain and RING finger protein 3.
Protein: APAH_SHIDS
Sequence: MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFTGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLPTAKDCARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGIYALDTGCCWGGSLTCLRWEDKQYFVQPSNRHKDMGEGEAVAS
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: RIMO_SHESA
Sequence: MTVETFNPKQTTTLETPAKTLEAASADLANAESATGNRIGFVSLGCPKNLVDSERILTQLRIDGYEVTNSYDNADLVIVNTCGFIDAAVEESLDAVREALEENGKVIVTGCLGAKENQIREVHPDVLEITGPHSYEAVLKHVHKYVPKPEHNPFTSLIPQTGVKLTPKHYAYLKISEGCDNRCTFCIIPALRGDLDSRPAGSVLDEAKRLVESGVQEILVVSQDTSAYGKDKGGRTDFWNGMPVKQDITSLARQLGKMGAWVRLHYIYPYPWVDDLIPLMAEGLILPYLDIPMQHASPRILKMMKRPGRVDRQLEAIQRWREICPDLVIRSTFIVGFPGETEEDFEMLLDFLREARLDRVGCFKYSEVEGAVANTIAELISEDVKEDRYHRFMEVQAEISAERLARFVGRTMDILIDDVDEEGAIGRSFADAPEIDGMVFINGETELEPGMLVRAVITHSDEHDLWAELVDADAEDDIEA
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_ROSS1
Sequence: MKAFFEKLLGFGPDRAIKQIEPIVRRINSLEPSVEALSNAELRAKTDEFKQRLADGETLDDLLPEAFAVVREAARRTIGQRHYDVQLIGGIVLHQGKIAEMKTGEGKTLVATLPLYLNALTGRGCHLVTVNDYLAKVGAGWMGPIYHLLGLSVATISHEYSAIYDPDYVDPKANPDDRRLVHWRPCSRREAYLADITYGTNNEFGFDYLRDNMAWDLAQLVQRELHYAIVDEVDNILIDEARTPLIISGPAQESGDEYRRFATLVRHLKPSPYTPDQIKKQMIEDPEGDFVIEPRSKSIQLTDQGVAKIERLLKIPEGESLYDPKYYRLTHYLDNALRAEFIYQRDRDYIVEHGEVIIVDEFTGRKMPGRRWSDGLHQAVEAKEGVKPRQENVTLATITFQNYFRMYQKLAGMTGTAYTEREEFAKIYNLEVVVIPTHRPMIRKDYDDQIYRSEKAKFEAVIREIEEMHAIGRPVLVGTTSVETSERLSEMLKRRGIKHEVLNAKYHEREARIVAQAGRKGAVTIATNMAGRGTDILLGGNPDGLIEEILAQRGIKIEQATPEQIRAAQEEARRITEAEGKEVRELGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDDLLRRFGPMDRVKGLMERLGVDDSLPIEAGLINRTIESAQTRVEGYNFDIRKHTVEFDDVMNKQRTVIYADRRRILEGENMRERVLDMIADEVHALVERYLPETKGRADDFEEWDIEGLVRAVRTIDPLLDETKLSPEQLEHLSRQEIEDAIMQAIEDDYQEREKAIGEENMRLVERRMMLSAIDRQWIDYLTGMEDLRQEIGLQAVAQRDPLIEYQRNAYAMFEELKANIQRDIVYQIIPVSFQYEQHLRQVEAEQQRRLLAAQQAGAADGNAKGARTVRHSVRLPGRNEPCPCGSGKKFKVCHWGREEELIALLQQRQTDQHAAVAADTPAQPAPQATATRPPTSQVPRGRAAPPPANPQPRSGKSPAQAPRGKGASARKK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: GIP1_SOYBN
Sequence: MPPPLPSLCNFNLAILFLFLTPTFQIPLIAPISKDDTTQLYTLSVFLKTPLQPTKLHLHLGSSLSWVLCDSTYTSSSSHHIPCNTPLCNSFPSNACSNNSSLCALFPENPVTRNTLLDTALIDSLALPTYDASSSLVLISDFIFSCATAHLLQGLAANALGLASLGRSNYSLPAQISTSLTSPRSFTLCLPASSANTGAAIFASTASSFLFSSKIDLTYTQLIVNPVADTVVTDNPQPSDEYFINLTSIKINGKPLYINSSILTVDQTGFGGTKISTAEPYTVLETSIYRLFVQRFVNESSAFNLTVTEAVEPFGVCYPAGDLTETRVGPAVPTVDLVMHSEDVFWRIFGGNSMVRVAKGGVDVWCLGFVDGGTRGRTPIVIGGHQLEDNLMQFDLDSNRFGFTSTLLLQDAKCSNLKVNNFANGIK
What is the function of this protein?
(Microbial infection) Possesses stronger binding affinity with XLP1, a truncated paralog of P. sojae XEG1 which has no enzyme activity.  Is impaired in its inhibitor activity towards the P. sojae xyloglucanase XEG1 when hijacked by XLP1 binding.
What are the official names of this protein?
Probable aspartic proteinase GIP1, Glucanase inhibitor protein 1, GmGIP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: H2A3_MEDTR
Sequence: MDASTKTTKKGAGGRKGGGPRKKSVTRSIRAGLQFPVGRIGRYLKKGRYAQRVGTGAPVYLAAVLEYLAAEVLELAGNAARDNKKNRIIPRHLLLAVRNDEELGKLLAGVTIAHGGVLPNINPILLPKKTERANTGGKEPKTTKAGKSPKKA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Probable histone H2A.3.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RB11A_HUMAN
Sequence: MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  The small Rab GTPase RAB11A regulates endocytic recycling.  Acts as a major regulator of membrane delivery during cytokinesis.  Together with MYO5B and RAB8A participates in epithelial cell polarization.  Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.  Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells.  Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane.  Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane.  Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.  May also play a role in melanosome transport and release from melanocytes.
What are the official names of this protein?
Ras-related protein Rab-11A, Rab-11, YL8.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle membrane. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279). Localizes to the cleavage furrow (PubMed:15601896). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
Protein: DUN1_YEAST
Sequence: MSLSTKREHSGDVTDSSFKRQQRSNKPSSEYTCLGHLVNLIPGKEQKVEITNRNVTTIGRSRSCDVILSEPDISTFHAEFHLLQMDVDNFQRNLINVIDKSRNGTFINGNRLVKKDYILKNGDRIVFGKSCSFLFKYASSSSTDIENDDEKVSSESRSYKNDDEVFKKPQISATSSQNATTSAAIRKLNKTRPVSFFDKYLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHPWFNDIQQQSSVSLELQRLQITDNKIPKTYSELSCL
What is the function of this protein?
Transducer of the DNA damage signal.  Phosphorylates SML1 on serine residues.  Cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.
What are the official names of this protein?
DNA damage response protein kinase DUN1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLYA_STRP4
Sequence: MIFDKDDFKAYDADLWNAIAKEEERQQNNIELIASENVVSKAVMAAQGSILTNKYAEGYPGRRYYGGTDVVDVVETLAIERAKEIFGAKFANVQPHSGSQANCAAYMSLIEPGDTVMGMDLASGGHLTHGAPVSFSGQTYNFVSYSVDPETELLDFDAILKQAQEVKPKLIVAGASAYSQIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPVPYAHITTTTTHKTLRGPRGGLILTNDEELAKKINSAIFPGIQGGPLXHVVAAKAVSFKEVLDPAFKEYAANVIKNSKAMADVFLQDPDFRIISGGTENHLFLVDVTKVVENGKVAQNLLDEVNITLNKNSIPYESLSPFKTSGIRIGAAAITARGFGEEESRKVAELIIKTLKNSENEAVLEEVRSAVKELTDAFLLYED
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_SODGM
Sequence: MLDRIKIALQHLLPKRWLTELAGWGAERRGGWLTRGVITLFVRWYKVDMQEAQQPDVATYPTFNAFFVRPLRDEARPIDADPAVLVLPADGIISQLGPIEGEQVFQAKGHHYSLEALLAGNESMITRFRDGSFATTYLAPRDYHRVHMPCNGVLREMLYVPGELFSVNPLTAANIPNLFARNERIICLFDTDFGPMAQILVGATIVGSIETVWAGTVTPPREGIIKRWRYPQADADGAVVLLKGQEMGRFKLGSTVINLFAGKNVLLGEHLYTRYVTRVGQRLAHGIAQTDSPLT
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SYI_BACAC
Sequence: MEYKNTLLMPKTEFPMRGNLPKREPAMQEKWAEMNIYETVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIYVAFSVKDGKNVLEGDEKYIIWTTTPWTLPANLGISVHPELEYAIVKVNDEKYIIASELFETVAKTLEWENAEVVKTVKGSELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDPIITDETINHVADLFREHGSNVWFEREAKDLLPEGFTHPGSPNGEFRKETDIMDVWFDSGSSHQAVLEERDDLQRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENTVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVTEESVQLTDMPEAVQLDDAEALKTKWDAFMTLRDDVLKALEVARNEKVIGKSLNASITLYPTAEMKAMLESINEDLKQLFIVSEYKLGGMMEEAPADAPKYEHTAVVVAQATGETCERCWVVSETIGKDAEHETLCERCATVVKENYVK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_PSECP
Sequence: MSRIGRLPITVPAGVEVRVDGSVVSVKGSKGELSHTVASPIEVALDDTTLTVSRPNDERASRSLHGLTRTLIANMIQGVTAGYEKKLEIVGTGYRVQAKGSDLEFALGYSHPVSVSAPDGITFAVEGPTKLSVSGINKQQVGEVAANIRKLRKPDPYKGKGIRYAGEVIRRKVGKAGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RL9_SALEP
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPKGKAVPATKKNVEYFEARRAELEAKLADVLAAANARAEKINALETVTIASKAGDEGKLFGSIGTRDIADAVTAAGVDVAKSEVRLPNGVLRTTGEHEVNFQVHSEVFAKVIINVVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.