Protein: NTNH_NECSZ
Sequence: MIVPETRPGPSPIAIVGIGLRLPGGCHDAQSYWDLLVHQKDARKPIPPERFNIDGFHKESDGVGSLSMRHGYFLDEPADRFDAGFFSMSQTEVARVDPQQRLLLEVMHEALENAGEVGWRGSNIAVYAGSFGQDWLQMQARDPQDGNVYGITGMDDFVLANRVSYEFDLHGPSMTVKAGCSSSLIALDLACEALQRGDCSGALVGASNLLLSPEYFLALDNLGALSSAGSSNTFDTNASGYARADAVNAVYVKRLDDALRDGNPIRAIVRSTAVNSDGKTVGLTNPSTDAQARLIRRAYEKAGIINPGETPVVECHGTGTATGDPQEVAAVVQVFSVMKLTQIPQVKPNIGHGEGAAGLSSLIKAVLSLERNTIPPNIKFTTPNPKIPFTEARLVVPTKATPWPKGRSRRISVDSFGLGGANAHVILEGYSTTPSPHRNGIPKVNGHTKTSTLQRLLVFSAHNETSIAKMTSNYQAFTESESYRVKDLAYTLGARRSHHKWRSFCITDGKSLQPTPAVRSSDPKGLLFIFTGQGAQWSDVLLNSQEISSAEYAQPLCTAIQIGLTNLLREWKITPDGVVGHSSGEIAAAYAVGALEMRDAIHVAFYRGVASSQQKRPGAMAAVGLGRHEVSNLLSAGTTIACENSRSSVTISGDYDAVEDTLDRVRQYWPDALARKLKIDRAYHSDHMRSVGILYEELISEIKTSTKSLTIPFFSSVTGQATYDASLLGPTYWRANMERPVLFLSAVENALDSMQEFGLALELGPHSALSGPFRQICKELDKRIIYNSCLSRGADATTTILTAIGQLYCQGLAPDFSALNPGGVTMSNLPPYPWTHDASYWNESRISREFRTRPHPEHELLGARVIGGNDMEPSWRKLLNLKEVAWLSDHVVAEDVVFPAAGYVAMAGEAIKQITGTAGFTIRSLSIGSAMPLNNARATEIITRLQPHRLTDDQDSTWFDFSVMSYDGNTWTRHCNGKVHPGNASTLSMEEKKSSPAEDGVRGVISAKWYQAAKAAGLEYGPTFQGLQDASYNVTRDCISSTLQTPLQTSSVLHPTTMDQLLQCCILGSVKGHLRLMSKLVLPVHIDEMYIADSHSFEGLYCETHSDFTGADMMEARGHIRVGNGSLALQAKGIRFRILENNRSKENALQELRLLEWRPSIDLVDLRQLVQQTTDLSGCLELVERLNILCVLGTTRILKSMENTQHHFKRFKEWNEEYVNNIRLNGSNVVQDTDHIFEMTSAECEFAIKELTAEALETPARDIALAITRIFYDVENIFTGAAEPLAVLLRDDLLMKIYNFFNMLDHRHFFQLLGHNKKTLRIIEIGAGTGGFTSTIVPALTDSAGGCLFSTYTYTDISSGFFKAAKERFSEYPGIEYTVLDISEDPASQGLELNSYDLVVAANAKAKWVNYIMGTLSGWWLGEPDGRINEPYIQAQQWDDILQKAGFENVTAIMDQSPPFQLDNIVIANAVDDALAPPKALSLLVPDTTQVAGPAAELVSKFQSEGYEVSLCSLWDLPTAPLDIVSLLDIMEPQTFFQGLTDRDLRGLIRFITHTHGQKLLWLTGPAQISTKDPHSAMVLGFARTLRLELGTIFATMELDIAAEPSPWNSVVEVFAKLQSQGTDDLVDCEYALVDGTVQVPRYITRSSEAVLPVASEQISRQLHVAKPGLLSSLQWQGSSREAELKEGELEIAVRASSVNYQDALLALGHVHSNHGLGLDCAGIVTHINSRAGKDNLQVGDRVLCWSAGSLSTHVRADSQRCIKIPDTLNFDVAVTMPTTYGTMIRGLIEIDAMGVAAIQIARMQGAEIYATAATEEEKHFLTTEHDIPMSRIFSSQDNSFVTAIMHDTQSRGVDIVVNSLSGELLHESWKCVAEGGNMIDISGKDVSGHGKLDMALFNGNRGFHGLDMASLVSKKPSLTRRLLEASIKLYTDGLVKPIRPITRFSTSDVKHAFHQFQGHRPIGAICIEFPDDPLSFPIDSFDDKTRFREDRSYVLIGGLGGLGRSAAVWLAERGAGSIIFMSRSASPSVESTSLVRELKALGCEVQIFTGSVTDASAVENLVANAAKPIAGMLHLALVLKDEAVLDMTFDSWQGATEAKVQGTWNLHNALKDQPLDFFILLSSIYGVQGNPKQANYAAASTFLDAFVQFRQQLGLPASVIDLGVMEDIGFVSQHPTILENLRRAGAQLIRENDFIGALQLAVRASSQPAPAPPTLASGYVNRAQFVVGLGQHPPDARGLGLKVDGTIQGQNNTQAVAKEDGDALKQFMENATRDPSSLEDETAVAEFLAAQVAECLKTLLIFSDSSDLNLKLGLAELGVDSLIAIELQTWWIQNFATNVTILELTKSASVMDLGKLARSRILEELHGRDG
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the meroterpenoids nectripenoids A and B, as well as cochliquninone D and isocochliquninone E (PubMed:29797385).  The pathway probably begins with the HR-PKS ntnH that catalyzes two chain-extension steps to form a reduced triketide, which then primes the SAT domain in the NR-PKS ntnG to initiate three more cycles of extension to give a linear hexaketide corresponding to the polyketide part of nectripenoids (Probable).  The FAD-dependent monooxygenase ntnJ then performs an oxidative decarboxylation at C11 of the ntnH/ntnG product, via an electrophilic aromatic hydroxylation with concomitant ipso-decarboxylation (Probable).  The membrane-bound polyprenyl transferase ntnF then introduces a farnesyl group before the FAD-dependent monooxygenase ntnK functions as the first epoxidase on terminal C12'-C13' olefin, followed by a second epoxidation on C7'-C8' catalyzed by ntnA (Probable).  The terpene cyclase/mutase ntnI then initiates the sequential tricyclic ring formation through protonation of the terminal epoxide and catalyzes the regioselective and stereoselective 6/6/6-tricyclic ring formation (Probable).  The cytochrome P450 monooxygenase ntnM may then hydroxylate C1' (Probable).
What are the official names of this protein?
Highly reducing polyketide synthase ntnH, HR-PKS ntnH, Nectripenoid biosynthesis cluster protein H.