PharMolix/UniProtQA huggingface dataset:
Protein: RTP2_TRYBG
Sequence: MEGPSNPGENLGIISVNPNTCESIELTNQILAKTYTTSWTDMEVYARGNGRICTAYPDVDHPLQDVRGNVSSILERGERSGGFETHPPRDPVTPRERHGNIQTRGAVIAPTPFHVVAAIPQQTRKRRWDILDGMVRRTVSQSTVDPKTVVMCVYRREEEETYDVLDEEEQDDDLLGIPNPTPRRLRISQAGPQQNSWVDTRGRRAYGSQEEQDERTSTDQVSIFSHDETRELSSPLECPIVGCTASFVGPRRWEKAKSHIYGVHSLEEVREIPRGELICKGIVRCETCATLLPTSDRAKQAHRDDCRPYLPRKENIRRKRAAEREATEASAQQGIALRLERQGPYITPRDIEEPTNTTTESWWREKVATKRYLHRKEWPQWLDICRTVLLGYSASSQGERHQRQVMLLDLVRNHLHTRTARREQQQQRGKDNQEEEDRQKKEEKSLRNAWKPCASSVRQGGQPSSSQPKRLNRWSTAPKWLKQSGNCTRRRISMIFPGPPVEQPGVVSVDAEEVAKTIARRLTRGAAPGLDGWTRELLYPLTLDPALKMEIAAVVKDIINADVSMEVGRRLQATSLTVLRKPNGKYRPIGAESVWAKLASHIAISRVMKTAEKKFSGIQFGVGGHIEEAIAKIRKDFATKGSLAMLDGRNAYNAISRRAILEAVYGDSTWSPLWRLVSLLLGTTGEVGFYENGKLCHTWESTRGVRQGMVLGPLLFSIGTLATLRRLQQTFPEAQFTAYLDDVTVAAPPEELKNVCAATAEAMEALGIVNNADKTEVLELTGDTGFGTAVKRVREFLERTWPDPMSEEIREGVEKKAMETDRLFKAIVELPLYNRTRWRILAMSAMPRITFLLRNHDMQHTHRVASWFDERTTQVMEHILGQPMTERARNIAALPVSMGGCGIRRMAQVAEYAHQCAGEKGLQQRKTEEADQRQQDDLYATLGGADRQVFTANTAAGAGRPLTDAQVRLDDATFGVYLRERYCRVLPEGVKCLCGEDASNHHIHTGTKVHNKPRQMRHDIINSVFANGLRLCGFQCATEPRLNEVSKRRPDILIAGLDTYAVTDITVTYPGRVTVGNTAQGQRSVAAADPMKAALVAFQEKERKYSYWAIQNGLAFAPFVMLTNGAIFGKSRDWLRRVLRGQDHRLTVTTAFDGITADVVAAVLRGNVHVYSAAQARGETLR
What are the official names of this protein?
Retrotransposable element SLACS 132 kDa protein, ORF2.
Protein: CCT13_ARATH
Sequence: MGEEHPRKRSRQHFEAEARNVSLFESPQCETSKWYFSREEIERFSPSRKDGIDLVKESFLRSSYCTFLQRLGMKLHVSQVTISCAMVMCHRFYMRQSHAKNDWQTIATSSLFLACKAEDEPCQLSSVVVASYEIIYEWDPSASIRIHQTECYHEFKEIILSGESLLLSTSAFHLDIELPYKPLAAALNRLNAWPDLATAAWNFVHDWIRTTLCLQYKPHVIATATVHLAATFQNAKVGSRRDWWLEFGVTTKLLKEVIQEMCTLIEVDRRRNMPPPPPPPRRELSWAIPAAVKPVHMARAYPFHSYPLQSYRQAGIW
What are the official names of this protein?
Cyclin-T1-3, CycT1;3.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin T subfamily.
Protein: HMUV_BURPS
Sequence: MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGATVRGGVALNGEPLHAIDAPRLARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTHADGEIASQALALAGATALDARDVTTLSGGELARVQFARVLAQLWPPPGAAQPPRYLLLDEPTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPADVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CCA_SACS2
Sequence: MIEEEVLKIIKPTEEDKKGIEKVLEIIRERLNKLDFEVEGSFRKGTWLRQDTDIDVFVFYPKDVGKEYLERNALNDIINRIKDLDYTLAYAEHPYVIVNINNVEVDIVPALRVESGDKAITAVDRTPFHTKYVTSHLDERGKDEVRLLKRFMKGIGVYGAELKVQGFSGYATELLIIYYGNFRKVLEEASKWKHPIKIELTKPMKIFSEPLIIPDPVDPKRNVTAAVSLKNIATFSIAAKYYLKNPSIEFFFPSKKVEEKVKGDVLILRLNLDEKSSEDIVWGQIKRSVNKIERALKQYGFRVIDVQAWGDTNNITIAVQLESKNIGQYYLNIGPQYYSGTIEDFIQKNDNIWVGEDGRLYSIKERKEYDAETIAKKNIVLKVKYNIESYWLQNTEDQQIMKFLRKTPTWLK
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
Protein: Y1147_METJA
Sequence: MFILIIKCGIMEKEVISSREFIDRFVECLEKGEDFKLKDCVVEGNVDILNIYEMIKDKELKGGYIEKKDDEIVVNINIKVDIYNVEFNGDFRFFVNMEYQIVISVFNGNAYFRVITFKGSVYFIRTIFNGDVDFIDTIFEENAYFSVTAFKGNIINFSGTIFNKESHFKSTTFEGNTYFSVTTFNIAEFYNSTFKSHVYFDDISFNLLSFTDCRFRDDVSFKKIDKENFKGLAIFLKTQFLNKHTTIENFQLSKTSFLKTDVREVLLCDVKKEEILSHKILRIKEDSGNKDKDLENKLKELLGLSYKYIIDQFNYKSVLAEYRNLRISIENNRTYIEASNLYKMEMELIKEFSNGRFEKFIIGAYGAISDYGESMEKTGKWILGSMILFTILASILRFKGMEWDIFKIIEFWWISFWEVIRLFLQIGTEDKSLWILEPIIRVTSLILLGNLYIAVRRKLSRK
What are the official names of this protein?
Uncharacterized protein MJ1147.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 400R_IIV6
Sequence: MKLLNFILIIFNALKSRHLIRCLDSKCHKLFPLLEVNKSTTSL
What are the official names of this protein?
Uncharacterized protein 400R.
Protein: SURE_SHEB8
Sequence: MIRILVSNDDGVNAPGIKALTEALTEIATVLTVGPDRNCSGASNSLTLTNPLRINRLDNGYISVHGTPTDCVHLAIRELYDGEPDMVVSGINAGANMGDDTLYSGTVAAAMEGRFLGFPAVAISLNGRKFEHYQSAAVYARRIVQGLLAQPLAKDQILNVNVPDLPLDQIKGIKVTRLGARHKAEGIVRTQDPAGREIFWLGPPGQEQDATEGTDFHAIANGYVSITPLTVDLTAYGQLTALQNWVDKI
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_STAES
Sequence: MIKKRVIPCLDVKDGRVVKGIQFQSLRDIGNPVDLALYYNEAGADELVFLDISKTEAGHDLMIEVIEATAKQLFIPLTVGGGIQNLDDITQLLNHGADKISLNSSALKHPELIRQASEKFGRQCICIAIDSFYDKDRKDYFCTTHGGKKLTDVRVYDWVQEVELLGAGELLITSMHHDGMKQGFDIEHLAKIKQLVNIPIIASGGGGNAQHFVELFQQTDVSAGLAASILHDQETTVAEIKDKMREGGILVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIR4_BOVIN
Sequence: MRMSFGLTFKRTAKVHWRANFSQQCSLRSTGLFVPPSPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPVRQRYWARNFVGWPQFSSRQPNPAHWALSNWERLGKLHWLVTQNVDALHTKAGSQRLTELHGCMHRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLTEEEVQSFQVPSCSRCGGPLKPDVVFFGDTVKPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAREKKLPIVILNIGPTRSDDLASLKLDSRCGELLPLIDPR
What is the function of this protein?
Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase.  Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications.  Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner.  Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity.  Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest.  In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation.  Acts as a tumor suppressor.  Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis.  Does not seem to deacetylate PC.  Controls fatty acid oxidation by inhibiting PPARA transcriptional activation.  Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels.  Down-regulates insulin secretion (By similarity).
What are the official names of this protein?
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial, NAD-dependent ADP-ribosyltransferase sirtuin-4, NAD-dependent protein biotinylase sirtuin-4, NAD-dependent protein deacetylase sirtuin-4, Regulatory protein SIR2 homolog 4, SIR2-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class II subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SYGB_CERS1
Sequence: MPDLLIELFSEEIPARMQARAREDLKKLVTDGLVEAGLTYASAGAFSTPRRLVLSVEGLSAESPTLREERKGPKADAPAAAIEGFLRSTGLTRDRLETREDKKGAVLFAVVEKPGRPAPEIVAEVLERTIRTFPWPKSMRWGTGSLRWVRPLQSILCLLSDEGGAEVVPMTLDGLTAGNSTEGHRFMAPARFAVSGFEDYRAKLGRAFVMLDASEREQAIWHEATTQAFAQGLEVVPDAALLSEVAGLVEWPVVLMGAIGEDFLGLPPEVLQTSMREHQKFFSVTNPATGRIEKFVTVANRETADHGETILKGNGKVLSARLSDARFFWENDLRTVKTAGLEGMAEGLKQVTFHNRLGSQADRIARIEALAREIAPLVGASPDLAAEAARVAKADLQSAMVGEFPELQGTMGSYYARAAGLPEAVAQACKAHYQPLGPSDAVPTDPVSVAVALADKIDTLAGFWRIGEKPTGSKDPFALRRAALGVIRLLLTNNSRAGLMGIMLPAMNRHLEPFDTSDFTPYERELLSFFHDRLKVHLREQGIRHDVIDACLAMPGNDDLTLLVKRAEALSAFLKTDDGTNLLQGFKRANNILTQAEAKDGVEYSFGADPKFAETDAERALFAALETAEAAIGPALQAEDFAAAMSAMAALRAPIDAFFETVQVNADNAVLRRNRLNMLHSIRATCARVADLTRIEG
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAI_PROMA
Sequence: MSSEFAATWLPAVFVPLIGLVTPAVFIVLIGRYITATD
What is the function of this protein?
May help in the organization of the PsaL subunit.
What are the official names of this protein?
Photosystem I reaction center subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PsaI family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: NS1_I78A7
Sequence: MDSNTVSSFQVDCFLWHVRKQVVDQELGDAPFLDRLRRDQRSLRGRGSTLGLDIEAATHVGKQIVEKILKEESDEALKMSMASTPASRYITDMTIEELSRDWFMLMPKQKVEGPLCIRMDQAIMEKNIMLKANFSVIFDRLETLILLRAFTEEGAIVGEISPLLSFPGHTIEDVKNAIGVLIGGLEWNDNTVRVSKTLQRFAWGSSNENGGPPLTPKQKRKMARTARSKVRRDKMAD
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: IGIP_HUMAN
Sequence: MCSYYHMKKRSVSGCNITIFAVMFSHLSAGKSPCGNQANVLCISRLEFVQYQS
What is the function of this protein?
Enhances IgA secretion from B-cells stimulated via CD40.
What are the official names of this protein?
IgA-inducing protein homolog.
What are the subcellular locations of this protein?
Secreted.
Protein: ADRB1_FELCA
Sequence: MGAGALALGASEPCNLSSAAPLPDGAATAARLLVPASPSASPLTPTSEGPAPLSQQWTAGIGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVMRGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAEGDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLSGPARPPSPAPAPGSPRPAATAAAAAAAAPLANGRISKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCFARRAARGGHAAAGDRPRASGCLPGTRPPPSPGAASDEDDDDDVGAAPPARLLEPWAGCNGGAAAADSDSSLDEPGRPAGASESKV
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  This receptor binds epinephrine and norepinephrine with approximately equal affinity.  Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity).  Involved in the regulation of sleep/wake behaviors (By similarity).
What are the official names of this protein?
Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity).
Protein: Y110_SIRV1
Sequence: MRIEDPFQNIFGVVRIAIDKIKELEQRGQIYGLSRFLPNSIIVMKTIDYPLIVDLYIPGFTFYFQFSIIQDQQTKQIFIDDFRVVYPQPYAKQINSTANFELSEEENEDE
What are the official names of this protein?
Uncharacterized protein 110.
Protein: JIP5_USTMA
Sequence: MDIPLSSDALDLCFHPAAETNLLAVGLISGKIQLINYDDYLSSPSSSRTPLAPPSKKSKPSTISSAVETPTKLYRKLYTSRPSKKSCRGLHFSTTGSSIFSISKDKSLFSTDTQTGKVVQSWIEVHDAAPSRVLPVDESLVVTGDDDGVVRLWDVRKGGGKGIKPVRMWEHHFDWITDMVYLADLPVPKPKSIKEAKKSKTQLKKQRRRARQAERLKEHDKEKREQNASDTEASEPDSEDDAAIKVESRSRLIVTSGDGSLSSIDLLSSGPTSFEQSEDQEDELLSITSIRSSTKLVVGTQLGILSLWTPSRGLLDHVDRVPGHPASVDTLVTLDNETVLTGSSDGLVRVVQILPSKLLGVIASHNGLPVERMKRKQSVLASIGHTNAVKLTDLSPLLDDNDDQGDDDDEQAGALGIVGLAEDDSDDDDDDDDDDDDDDDEKHLVVELDGAEQTDGDAESGQDDEQDPDSEDVTPSQNKAGKGGFFSDL
What are the official names of this protein?
WD repeat-containing protein JIP5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RSMA_PROMT
Sequence: MGGDNTLNDFRHIPRKRFGQHWLKDQGVLDQIVKAAELNPEDCVLEVGPGKGALTEKLIESQARFIQAIELDRDLVVGLKKRFSHQNKFSLREGDILSAPLDAENGLTINKVVANIPYNITGPLLKRLIGELRKAPDNCFETLVLLMQKEVAQRLLARPGTSNFSALSVRIQLLAKCQDVCDVPSKCFQPAPKVDSKVVMIKPFASIDPDFYEVGNLLEKLLKHAFAGRRKKLRNTIGSFVTSNDQIKEFFAYRGISLDQRPQEISPSNWFGLAKALKETCVIENGTFQSK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_SYNJA
Sequence: MQPRRVARELALLGVNQLPATAAKLSEKQLEDLLLAAIRALQEETHETLSTAAAEIQRSDRLLHESDPLLLAASDAKEEGGARSLTVRLQQAQRHLQRLETALKEANAGDTVQGELLELAHQAQVALSNAGQALEHLEQRLYSVRRILDEVVQLSQKAVNRLGVALSMPELLHIAQAQEVRAYALQLLTALRTHKEAIDARLQGVLVGWQLKRVGRIERDILRLAVVEMEILRSSPDKVAINEAVELAKKYGDPEAAAFVNGVLRRLVDSRMEAPFGRNPSPAGDLRS
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: GBRA1_CHICK
Sequence: MKRLLVLCDCLWAWSLLLNALTERSYGQTSSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDVHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYTAAATSYTPNIARDPGLATIAKSATIEPKEVKPETKPAEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity).  Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: FRPD2_HUMAN
Sequence: MQPLTKDAGMSLSSVTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSSDYVVCPWSALLSAAGSLSFQGRVSHIEAAPFKAPELLQGQSEDEQPDASQMHVYSLGMTLYWSAGFHVPPHQPLQLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTISEVEKRVVEESSSVQQNRSYLLRKRLRGTSSESPAAQAPECLHPCRVSERSTETQSSPEPHWSTLTHSHCSLLVNRALPGADPQDQQAGRRLSSGSVHSAADSSWPTTPSQRGFLQRRSKFSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNTFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTITSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMANLSPAHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQLKSACVIQKPMTWDSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYSFSSPLTRLSTDIF
What is the function of this protein?
May play a role in the regulation of tight junction formation.  Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2).
What are the official names of this protein?
FERM and PDZ domain-containing protein 2, PDZ domain-containing protein 4, PDZ domain-containing protein 5C.
What are the subcellular locations of this protein?
Cytoplasm. Basolateral cell membrane. Cell junction, tight junction. Note=Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1.
Protein: RL13_HELHP
Sequence: MELTKIATQNDINRQWIVLDAKDKVFGRLITEIATLLRGKHKPCFTPHIDCGDFVVIINATEVKFTGMKLKDKEYFTHSGYFGSTKSKTLQEMLEKTPEKLYHLAVRGMLPKNKLGRAMLKKLKVYRGSEHPHSAQVAKSSK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: Y5828_ARATH
Sequence: MAMAYEEARKLRLQENHKRFQSNFVALPQFQLLQQRNHKPIDKALLATAEPRRSSRVRTVISSYRDDVVVDTGRTSNLRRSRHSSTWATYISRPLHECKFASYEEKVGAFKAAEKFQRSLKSPHPYFVKSMVRSHVYSCFWLGLPSRFCADNFPEETMEIELEDEEGEVYEAVYIGRRAGLSGGWKRFALDHKLDDGDALLFELVEPKKFKIYVFKGNENANLTSARKRGRATTPSEEEEEEEDKDVEESGDEEHSSRATKRSSVRLLRKRKA
What are the official names of this protein?
Putative B3 domain-containing protein At5g58280.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1737_STAAN
Sequence: MTNGYIGSYTKKNGKGIYRFELNENQSRIDLLEIGFELEASTYLVRNNEVLYGINKEGEQCGVASLKIDDNGELHLLNKCLSSKAGTGCYVSISEDKRYLFEAVYGAGIIRMYELNTHTGEIIRLIQELAHDFPTGTHERQDHPHAHYINQTPDGKYVAVTDLGADRIVTYKFDDNGFEFYKESLFKDSDGTRHIEFHDNGKFAYVVHELSNTVSVAEYNDGKFEELERHLTIPENFDGDTKLAAVRLSHDQQFLYVSNRGHDSIAIFKVLDNGQHLELVTITESGGQFPRDFNIASSDDLLVCAHEQGDSVVTVFERSKETGKITLCDNTRVASEGVCVIF
What are the official names of this protein?
Uncharacterized protein SA1737.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: AUSH_PENBI
Sequence: MSPTRDELLCTALDFVAQFAKLDPESVLSFLSPSCTLRSFPSSLGKPPLQTKEESKADFQGLKDFFHNFQLRVKDGAEPVVDEPARKVVLHIEGKGDSLVGRFETEYIYILQMNEEGTMVEDFFQFADSATRDAWGKKIEAHFSAKN
What is the function of this protein?
Part of the gene cluster B that mediates the biosynthesis of the fungal meroterpenoid acetoxydehydroaustin (PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (By similarity).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (By similarity).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG then modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:29076725).  The cytochrome P450 monooxygenase then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:29076725).  The hydroxylation catalyzed by ausR permits the second O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:29076725).  Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end product of the Penicillium brasilianum austinoid biosynthesis clusters is acetoxydehydroaustin (PubMed:29076725).
What are the official names of this protein?
Austinoid biosynthesis clusters protein H.
What is the protein family that this protein belongs to?
Belongs to the trt14 isomerase family.
Protein: PSAC_CHLRE
Sequence: MAHIVKIYDTCIGCTQCVRACPLDVLEMVPWDGCKASQMASAPRTEDCVGCKRCETACPTDFLSVRVYLGSESTRSMGLSY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.