PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_RICTY
Sequence: MTNILSPEKSENDQELPIRPSYLQEFVGQQQIKENLLVFIKAAKSRNEHLDHTLFYGPPGLGKTTLAKIISNEIGGNFKSTAGPAIIKAADLAAILTNLEKNDVLFIDEIHRLNTLVEEILYSAMEDFELDIIIGEGSAARSVKITLPKFTLIGATTRFGMLSNSLRDRFGIPMRLNFYNTEELKQVLNRASKLLDIDLTDSGSEEIAKRSRGTPRIALRLLRRIRDFAVVDGKLRIDKEICDFGLKRLTVDSIGLDSNDYRYLKFIADNYHGGPVGIETIAAALSEQRDELEETIEPYLIKIGLVKRTPRGRVITIAAFEHLKMPIPNKSQHQFNILNENE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: YCGL_SALPB
Sequence: MRQVTIPLIQSKSMFCVIYRSSKRDQTYLYVEKKDDFSRVPEALMKGFGQPQLAMMLPLDGRKKLVNAELEKVKQALSEQGYYLQLPPPPEDLLKQHLSSVGQNTSPADR
What are the official names of this protein?
Protein YcgL.
Protein: IF2G_METKA
Sequence: MDDERFQQAEMNIGMVGHVDHGKTTLTKALSGVWTDTHSEETRRGISIRLGYADTVLTRCPECDTYSVEEKCPECGAETEWLRRVSFVDSPGHETLMATMLSGAAIMDAAILVIAANEPCPQPQTREHLMALEIIGTEDVIVVQNKIDLVTPEEAREHYEQIVQFLEEETHLDPDKTPIIPVSAQHKANLDVLVEAMYEHFEPPEYDLDAPFRMYIARSFDVNKPGTRPSDLKGGVIGGAIVQGEVEIGDEIEIRPGIRVERYGRTEWEPVYTEVVSLHANVTPVERARPGGLVGIGTKLDPTMTKADRLSGQVAGEPDTLPPVRHELLLEVELLERVVGTEEERKVEPIRTNEVLMLTVGTATTVGVVTSARDDEIEIKLKQPVCAEEGDRVAISRRIQRWRLIGHGVIKG
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit gamma, aIF2-gamma, eIF-2-gamma.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: NSDHL_RAT
Sequence: MEQAVRSESKKGQVTGTDLINEVSKAKKCTVIGGSGFLGQHMVEQLLSRGYAVNVFDVRQGFDNPRVQFFIGDLCNQQDLYPALKGVSTVFHCASPPSNSNNKELFYRVNSTGTKTVIETCKEAGVQKLILTSSASVVFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLDANDPKKNFLTAAIRPHGIFGPRDPQLVPVLIDAARKGKMKFMIGNGKNLVDFTFVENVVHGHILAAEHLSRDAGLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYRVAYYLAFLLSLLVMVLSPLIQIQTTFTPFRVALAGTFHYYSCEKAKKLIGYRPLVTMDDAVERTVQSFHHLRKDK
What is the function of this protein?
Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis.  Also plays a role in the regulation of the endocytic trafficking of EGFR.
What are the official names of this protein?
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 3-beta-HSD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Lipid droplet. Note=Trafficking through the Golgi is necessary for ER membrane localization.
Protein: MRGX2_MACFA
Sequence: MDPTTPAWGTESTTMNGNDQALPLLCGKETMISVFLILFIALVGLVGNAFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQMTNCLAYLINFFGSISINFPSFFTTVMTCACLAGLSMLSAISTQRCLSILWPIWYRCRRPRHLSAVMCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLMFLFVVLCGSSLALLVRILCGSRSLPLTRLYLTILLTVLIFLLCGLPFGIQWFLILWIWKNSDVLFCHIHPVSVVLSSFNSSANPIIYFFVGSFRKQWRLRQPILKLALQRALQDTAEVDHSEGCFSQGTLEMSRSSLV
What is the function of this protein?
Mast cell-specific receptor for basic secretagogues, i. e.  cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core.  Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium.  In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction.
What are the official names of this protein?
Mas-related G-protein coupled receptor member X2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VATD_STRPZ
Sequence: MARLNVKPTRMELSNLKNRLKTATRGHKLLKDKRDELMRRFVDLIRENNELRQTIEKELAANMKEFVLAKASENSLMVEELFAVPVHEVTLWIDIENIMSVNVPKFHVQSNTAREQEQGEFAYSYLSSNSEMDNTIQKTKELLEKLLRLAEVEKTCQLMADDIEKTRRRVNGLEYSIIPQLEETIHYIELKLEEAERASLVRIMKITS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: VATE1_ARATH
Sequence: MNDGDVSRQIQQMVRFIRQEAEEKANEISVSAEEEFNIEKLQLVEAEKKKIRQDYEKKEKQADVRKKIDYSMQLNASRIKVLQAQDDIVNAMKDQAAKDLLNVSRDEYAYKQLLKDLIVQCLLRLKEPSVLLRCREEDLGLVEAVLDDAKEEYAGKAKVHAPEVAVDTKIFLPPPPKSNDPHGLHCSGGVVLASRDGKIVCENTLDARLDVAFRMKLPVIRKSLFGQVTA
What is the function of this protein?
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function.  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.  Required for Golgi organization and vacuole function in embryogenesis.
What are the official names of this protein?
V-type proton ATPase subunit E1, V-ATPase subunit E1, Protein EMBRYO DEFECTIVE 2448, Vacuolar H(+)-ATPase subunit E isoform 1, Vacuolar proton pump subunit E1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein.
Protein: CLPP1_ALKCK
Sequence: MNIPIPYVMEQTRYGERSYDIYSRLLKDRIIFIGDEITDTLANSVTAQLLFLASTDPEKDISIYINSPGGSVSAGFAILDTMLYIKPDIQTICTGMAASFAAVLLVGGTKGKRCALPHAEVMIHQPHGGMKGQASDMDIYAQRILKQRKEINHFIAERTGQTPDKIATDSERDYFMSAAEAKDYGVIDNILPV
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_BAUCH
Sequence: MVTINQLVRHPRSMKVAKSNVPALEGCPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTLRGTLDCSGVKDRKKGRSKYGVKKQKV
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SIX4_HOTTS
Sequence: DGYIKGNKGCKVSCVINNVFCNSMCKSSGGSYGYCWSWGLACWCEGLPAAKKWLYAATNTCG
What is the function of this protein?
Depressant insect beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis.  They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  This toxin is active only on insects.
What are the official names of this protein?
Insect toxin BsIT4, Insect toxin 4, Bs-dprIT4.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KATG_DESOH
Sequence: MDKDSKRPVVGSTVRGGMSNRDWWPNQLNLSILHQQSNKSNPMGEDFDYAKEFKKLNLAAVKKDLYALMTDSQEWWPADYGHYGGLFIRMAWHSAGTYRMGDGRGGAGSGSQRLAPLNSWPDNANLDKARRLLWPIKKKYGKRISWADLMVLAGNCALESMGFKTFGFAGGREDVWEPETDIYWGAEEEWLATSDKPKSRYSGDRDLENPLAAVQMGLIYVNPEGPDGNPDPVAAGYDVIETFARMAMDPEETVALVAGGHTFGKCHGAGPASHVGPEPEAAPIEAQGLGWKSSFGTGKGGDTITSGIEGAWKPYPTRWDMGYLKVLFKYEWELVKSPAGAYQWLAMDVDEEDMVIDAHDPSKKHRPMMTTADLSLRFDPVLGPIAKRFSKNPKAFADAFARAWFKLTHRDMGPRSRYLGPEVPKKELIWQDPVPAVNHKLIGARDIAALKREILASGLSVSQLVYTAWSSAVTFRGSDKRGGANGARIRLAPQKEWEVNQPAQLKKVLAKLEKIRRAFNSAQSDGKKVSLADLIVLGGCAAIEQAARNAGYKGTVPFKPGRMDATQKQTDAASFAVLEPLADGFRNYLKAKFTVSAEELLIDKARLLTLTAPEMTVLIGGMRVLNANYGQSPHGVFTKRPETLTNDFFVNLLDMGTVWNPAKADDCVFEGRDRQTGALRWTGTRVDLLFGSNSQLRAIAEVYACKDAGEKFVNDFVAVWNKVMNADRFDLA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: HITA_NEIGO
Sequence: MDNCIFCKIAAKEIPAQTVYEDGEMVCFKDINPAAPLHLLLIPKVHFDSLAHAAPEHQPLLGKMMLKVPEIAKASGLTDGFKTLINTGKGGGQEVFHLHIHIMGTPV
What are the official names of this protein?
Protein HitA.
Protein: ZNTB_VIBPA
Sequence: MGFMIEHWDFSTPMATQETTTAEHIQPNHWYHCERLHPDIRSWLEDNHVPRATVDHLLADESRPSFHPLDDDNFMLILRGINMNENASPEDMLSIRILYFQGALISTRKIPSRAIMEIRQALAEHKGPKSLASLLNQIIEGLNGKIDLYLDTIEETLNEFDVNDESTYNHIAAQKALISIKRFIRPQQYAIRDLIESESELVTSRPHQYRFAHNNITRINETIEFYLGEVALFQDEIKHNRDEKTNKNSYLFTLVATIFLPTSFLTGLLGINIGGMPGVESSMAFTWFCIALIVIFGLEWLLFKRLGFTNKTDDE
What is the function of this protein?
Zinc transporter.  Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.
What are the official names of this protein?
Zinc transport protein ZntB.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HLDD_POLSJ
Sequence: MKIVVTGAAGFIGSNLVKGLNDRGIDDIIAVDDLTHGDKFRNLADLQIADYIDADDFYDLFAEGAFGQVEAVFHEGACSDTMELDGKYMMDNNYTLSCELFHACQEQGTRLLYASSAATYGGSDTFSESPEFERPLNVYGYSKLLFDQRMRRELGARFENAATQVAGFRYFNVYGPREQHKGRMASVAFHQFNQFQAEGKVKLFGDYGGYQAGGQMRDFVFIDDVVAVNLWFLDHPEKSGIFNLGTGRAQPFNDVALAVVNTLRQSQNAAAMSLEDAVRGGLIDYITFPPALVGKYQSYTQADLQALRAAGCQHAFADVQTGVAAYMQWLASAKI
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: NSP4_ROT41
Sequence: MDKLTDLNYTLSVITLMNSTLHKILEDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSRCSYKVIKYCIVTIFNTLLKLAGYKEQITTKDEIEKQMDRVVREMRRQLEMIDKLTTREIEQVELLRRIYDRLTVQKTDEIDMSKEINQKNVRTLDEWENGKNPYEPSEVTASL
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: COAE_RICCN
Sequence: MLAIGITGSYASGKTFMLDYLTEKGYKTFCADRCIKELYQDVVLQTQILKLLPELESFNIRKISNLIYNNDLAREKLQNFIYPLLIDKLILFKKENANSKFGFAEIPLLYEAKFEKYFDFVVTIYCSEAIRMQRAITRSSFDIEIYNKIKEIQLSQESKIAKADFAINSGVDMLDLEKQIAKLIKDLECRV
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOE_PIG
Sequence: MRVLWVALVVTLLAGCRTEDEPGPPPEVHVWWEESKWQGSQPWEQALGRFWDYLRWVQSLSDQVQEELLSTKVTQELTELIEESMKEVKAYREELEAQLGPVTQETQARLSKELQAAQARVGADMEDVRNRLVLYRSEVHNMLGQTTEELRSRLASHLRNVRKRLVRDTEDLQKRLAVYQAGLREGAERSVSALRERLGPLVEQGRLRAATLSTRAGQPLRERAEAWGQKLRGRLEEMGSRTRDRLDEMRDELEEVRTKVEEQGSQLRLQAEAFQARLKGWFEPLVEDMRRQWAGLVERMQSAVSISSSTSAPSDNQ
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: NUOK_GEOSW
Sequence: MSSVPLSVYLVLALILFCIGLYGALTKRNTVIVLICIELMLNAVNINLVAFAKYGAHPGIAGQIFALFTITVAAAEAAVGLAILMALYRNRKTVHIDEIDSMKH
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RASW_DICDI
Sequence: MTSYKNNNVISLCIMGDGGVGKTAVTIQFISNHFVYYYDPTIEDSYRKQCLVDDQVYMLDILDTAGQDELTAMRDQWIRSCEGFILVYSVTSRSSFDQIQFFREQIIRVLDSDDVPIMMIGNKIDLDDERQVTFQEGKDLARCLGMSFMEVSAKNRTNVEEVFNETVRIVKRKEDPQSHKPSKDSDSKKPLVNTSKIIKKINTRVKQTKTSICKMM
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
What are the official names of this protein?
Ras-like protein rasW.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: HSLO_ACTSZ
Sequence: MTYQQDNDKLYRYLFQNRAVRGEWVRMNKSFSETLNTHHYPIAVQNLLGEMMVATGLLTATLKFTGHITVQIQGDGPLKLALVNGTDSQQIRALARLQGEISDDMTLHQMIGKGVLVITIAPEEGERYQGVVTLDKPTITECLEEYFERSEQLKTQLIIRTGEFNGEPVAAGMLLQVMPDGSGSPDDFEHLAALTATVKDDEIFGLTAEEMLYRLYHEEQVEIYAPQAVTFHCGCSAERSGAALLLISDAELDEILAEHNGSIDMQCECCGTHYFFNRDAIDKLKMQQ
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_RHIME
Sequence: MSDLKPFVAKVAAREALSREDARAAFEIIMSGAATPSQIGGFLMALRVRGETVDEIVGAVGAMRARMLPVEAPDGAIDIVGTGGDGAGTYNISTLAALIVAGAGVPVAKHGNRALSSKSGTADALSCLGVNLDIGPAVISRCIAEAGLGFMFAQQHHSAMRHVGPTRVELGTRTIFNLLGPLANPAGVRQQLVGVYAPQWVDPLAEVLRDLGSESVWVVHGEGLDEITTTGVTKVAALKDGTITNFELTPADFGLERVSLDALKGGDGAHNAAALQAVLDGAENAYRDISLANAAASLMIAGRAGDLSEGMALARQSLSSGGAKVALQRLITVSNAA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RR19_LIRTU
Sequence: MTRSLKKNPFVANNFLGKIEKLNMREEKEIIITWSRASTIIPTMIGHTIAIHNGKDHLPIYITDRMVGHKLGEFAPTLTFKGHARNDNRSRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: METAA_STRP4
Sequence: MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLMPQKMVTETQLLRHLANTPLQLDIDFLYMESHRSKTTRSEHMETFYKTFLEVKDEYFDGMIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQMDSKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVGVSILASRDLREIYSFGHLEYDRDTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLCWSSSAALFFSNWVNHAVYQETPFXWRKIXDDASAYGYL
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S22A6_HUMAN
Sequence: MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASAQEKNGL
What is the function of this protein?
Involved in the renal elimination of endogenous and exogenous organic anions.  Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc).  Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186).  May contribute to the transport of organic compounds in testes across the blood-testis-barrier (Probable).  Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity).  Also mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate.  PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity).  PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.
What are the official names of this protein?
Solute carrier family 22 member 6, Organic anion transporter 1, hOAT1, PAH transporter, hPAHT, Renal organic anion transporter 1, hROAT1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2129_VIBPA
Sequence: MPITSKYTDEQVEKILAEVALVLEKHAASPELTLMIAGNIATNVLNQRVAASQRKLIAEKFAQALMSSLETPKTH
What are the official names of this protein?
UPF0352 protein VP2129.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: Y1484_HAEIN
Sequence: MMDDLQDVSRLREAYQFYQKAKQDEDSIVCGCLNDAYEWLFSELKALFDEEEE
What are the official names of this protein?
Putative uncharacterized protein HI_1484 in Mu-like prophage FluMu region.
Protein: HIS2_LIMF3
Sequence: MQDLESLYQMVAARKANPKEGSYTDYLFTKGLDKILKKVGEETTEVIVAAKNEGTAELQYETADLLYHLMVLLVEQGLTYDDIKEELGKREGLMSDFKDRPEIKDL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.