PharMolix/UniProtQA huggingface dataset:
Protein: TBR1_MOUSE
Sequence: MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPSQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDIGGYYGFYSHS
What is the function of this protein?
Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:9883721, PubMed:11239428, PubMed:21285371).  As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (PubMed:21285371).
What are the official names of this protein?
T-box brain protein 1, T-brain-1, TBR-1, TES-56.
What are the subcellular locations of this protein?
Nucleus.
Protein: UVRC_ALKEH
Sequence: MTDVPSPFDPKAFVRSLTQRPGVYRMVDGRGEVLYVGKARNLKKRVASYFTRSRKSARIELMLTQVQDIQVTVTHTEAEALILENTLIKELRPRYNVLLRDDKSYPWIYLSSHQDFPRLSFHRGARKGPGRWFGPFPSGHAVRETLNTLQKVFRIRQCQDSFFSNRSRPCLQHQIKRCTAPCVGYISREAYQEDVRHAVLFLEGRSNQVIEELGARMEAASERLEFEAAAQYRDRIQALQAVQERQYIVGEKGDLDVIACVSDGVTACVTVFFFRQGRNLGNKVFYPRIPEGADEAEVLAAFLARYYIGRKAPPELVISHTIPEQKVLGEALSRESGHRVRVTHSVRKERRRWLEMALTNARHALTARTSTQAMALHRLEALQDALQLPALPERIECFDISHTRGEATVAACVVFNQDGPLKSDYRRFNIRGITPGDDYAAMRQALSRRYQRLKKGEGVLPDILLIDGGKGQVAQAEAVLEELQVDDVYLVGIAKGPERRPGEETLILSDEDGREKTLGPDAPALQLLQQVRDEAHRFAIAGHRQQRGKARTRSALEDIPGLGPKRRQALLRHFGGLKAVARAGVEDLARTPGISRALAQKVYDHYHGDSG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLII_HELPJ
Sequence: MPLKSLKNRLNQHFELSPRYGSVKKIMPNIVYADGFNPSVGDVVKIEKSDGTECVGMVVVAEKEQFGFTPFNFIEGARAGDKVLFLKEGLNFPVGRNLLGRVLNPLGQVIDNKGVLDYERLAPVITTPIAPLKRGLIDEVFSVGVKSIDGLLTCGKGQKLGIFAGSGVGKSTLMGMITRGCLAPIKVIALIGERGREIPEFIEKNLKGDLSSCVLVVATSDDSPLMRKYGAFCAMSVAEYFKNQGLDVLFIMDSVTRFAMAQREIGLALGEPPTSKGYPPSALSLLPQLMERAGKEENKGSITAFFSVLVEGDDLSDPIADQARSILDGHIVLSRELTDYGIYPPINILNSASRVAKDIISESQNLCARKFRRLYALLKENEMLIRIGSYQMGNDKELDEAIKKKALMEQFLVQDENALQPFEQSFQQLEEILR
What is the function of this protein?
Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.
What are the official names of this protein?
Flagellum-specific ATP synthase.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXB_YERPB
Sequence: MKILVDENMPYAEELFRRLGDVQAVPGRPIPRDALVDADALMVRSVTKVNEALLHGTSIGFVGTATAGTDHVDDTWLRQQGIGFSAAPGCNAIAVVEYVFSALMMMAERDGFQLRDKTVGIIGVGNVGSRLNARLQALGVRTLLCDPPRADRGDNEAFWPLEKLVREADVLTFHTPLNKTGAYQSLHMADDELLAALPDGRILINACRGAVVDNAALLRALEKGKKLSVVLDVWEPEPDLSLPLLARVDIGTPHIAGYTLEGKARGTTQVFEAFSQHLGQPQSVELASLLPVPEFSHLRLNGELDEGKLKRLMHLVYDVRRDDAPLRHVAGLPGEFDRLRKHYQERREWSSLCVQCDDATSAGLLQQLGFTTQLL
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORN_CORDI
Sequence: MVETVHPKNDRLVWIDLEMTGLELDRHVIVEVAALITDADLNIIGEGVDLVVHATPEQLAEMDDFVTTMHTSSGLLEEIKASTVSLQEAEDAVLALIAQHCDPEHPAPLAGNSIATDRSFIRAQMPRLDKALHYRMVDVSSLKELSRRWAPRVYFNQPDKGMAHRALADIVESIRELDYYRRAWLISDPTTEDAEDAKANATASYQQFLQ
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEU1_PIG
Sequence: MAGPSLACCLLGLLALTSACYIQNCPLGGKRAVLDLDVRKCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSEGRCAAAGICCNPDGCRFDPACDPEATFSQR
What is the function of this protein?
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.  Acts by binding to oxytocin receptor (OXTR) (By similarity).
What are the official names of this protein?
Oxytocin-neurophysin 1, OT-NPI.
What is the protein family that this protein belongs to?
Belongs to the vasopressin/oxytocin family.
Protein: RS4_JANMA
Sequence: MARYIGPKAKLSRREGTDLFLKSARRSLDSKCKLDSKPGQHGRTSGARTSDYGNQLREKQKVKRMYGILERQFRRYFAEADRRKGNTGETLLKLLEARLDNVVYRMGFGSTRAEGRQLVSHKAFTVNGIVVNIASYQVKPGDVIAVREKSKKQVRIVEALSLAEQSGMPSWVSVDAKKMEGTYKAAPDRSEIANDVNESLIVELYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: NAPD_PARPN
Sequence: MREPDRTPIQRRDILTGKLKQDSGGESRFLHISSAIVTARPDRAADLARHFATLPGTEVHAVQGAKIVLVLEGASVGEIRQPHGAISVMEGVFSANLVFEQILPADEREALS
What is the function of this protein?
Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase.  It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
What are the official names of this protein?
Chaperone NapD, NapA signal peptide-binding chaperone NapD.
What is the protein family that this protein belongs to?
Belongs to the NapD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_LACLM
Sequence: MSKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQKTTVKQIAGKKLAIVPILRAGIGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPADIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFVCLVAAPEGVKALQEAHPDIEIYTAALDEKLNEHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: RL35_VIBCH
Sequence: MPKMKNNKGAAKRFKKTAGGIKYKHATKRHILTKRTTKNKRQLRPNAILPKCELAAVARMLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: COAX_BURMS
Sequence: MCLLIDAGNSRIKWALADTARHFVTSGAFEHASDAPDWSTLPAPRGAWISNVAGDAAAARIDALIEARWPALPRTVVRASAAQCGVTNGYAEPARLGSDRWAGLIGAHAAFADEHLLIATFGTATTLEALRADGHFAGGLIAPGWALMMRSLGMHTAQLPTVSIDAATNLLDELAENDAHAPFAIDTPHALSAGCLQAQAGLIERAWRDLEKAWQAPVRLVLSGGAADAIVRALTVPHTRHDTLVLTGLALIAHSA
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GADA_DICDI
Sequence: MSLHHVKTNKYKGFYDSYASPPATKEISKYSLKEESNKPEVIRDLIIDELLLDGNAKQNLATFCQTDLDKEIHVLMDKCIDKNMIDKDEYPQTAEIESRCVHILADLWNSPESSETIGCSTTGSSEAAMLGGMALKWRWRENRKKQGKPFDKPNIVTGPVQICWHKFALYFDIELREVPMEHDRYIMTPEEAIKRCDENTIGVIPTLGVTFTLQYEDVKGISEALDKFEKETGLDIPIHVDAASGGFVAPFLQPEIVWDFRLPRVKSINGSGHKFGLSPLGVGWVVWRGKNDIHKDLVFDVNYLGGNMPTFSLNFSRPGGQIVCQYYNFLRHGRSGYTAVHQACLDHGIFISKQVKKHGIFDIVYDGTGALPGACWKLKKDAKVKFNLFDLSDRMRNRGWQIASYTLPNLPDIVVQRVLIRHGFSHDMAMLLIEDFNRSIEYFDKHPMVQSISKDEGQSFHH
What is the function of this protein?
Generates GABA from glutamate.  GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2.  Glutamate acts as a competitive inhibitor.
What are the official names of this protein?
Glutamate decarboxylase A.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: NAGB_HAHCH
Sequence: MRVIIADSPEAVARMGAEQCIRLLQDKPAAVLGLATGSTPIALYAHLIQRRQQGEVSFHQVRTFNLDEYIGIAPQHPQSYRSFMQKQLFDHIDVLPENTHIPNGMGDPIAESRAYEDKIHSAGGIDLQILGLGRNGHIGFNEPTSSLSSRTRAKTLTQETIRDNSRFFSADEEQPHLAITMGIGTILDARKIMLLAAGAAKADAVKAMVEGPISAMHPASALQMHPSALVIVDTDAASKLELIDYYRWVQSETLRVQGAYL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: MOAC_ALCBS
Sequence: MTEQRFTHLDDSGRAQMVDVTDKDITQRAATAQARVRMQPSTLQMILAGEHPKGDVLATARIAGIQAAKKTWDLIPLCHPLLLTGITVTIEPEADDALCVQATCKLKGTTGVEMEALTAASVACLTLYDMCKAVDRCMVIESVCLLEKSGGRSGTFRRER
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: LIPA_BACFR
Sequence: MGNDKRVRKPEWLKISIGANERYTETKRIVESHCLHTICSSGRCPNMGECWGKGTATFMIAGDICTRSCKFCNTQTGRPLPLDPDEPAHVAESIALMKLSHAVITSVDRDDLPDLGAAHWAQTIREIKRLNPETTTEVLIPDFQGRKELIDQVIKACPEIISHNMETVKRISPQVRSAANYHTSLEVIRQIAESGITAKSGIMVGLGETPAEVEELMDDLISVGCKILTIGQYLQPTHKHFPVAAYITPEQFAVYKETGLKKGFEQVESAPLVRSSYHAEKHIRFNNK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_CAMC5
Sequence: MKEILITNDDGFEAKGLHELADALRQIPDVNVTIVAPSSEKSACAHSLTLTKPLRFIKIDDNFFKLDDATPSDCVYLALHALYQKKPDLVISGINHGANLGEDITYSGTCGAAMEGVLQGIKSIAFSQFYKNNSIEELGFSLACQIVKFIVPRVLEGEICLPQRQFLNVNIPAVAARDFKGYKVAPAGRRCYATHATLNRNPRGVEYYWLGNAALDYEEGQISDISVINDGFASLTPIQLDMTAHASLENLKKSFQ
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAPK5_HUMAN
Sequence: MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
What is the function of this protein?
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation.  Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB.  Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53.  Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation.  Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB.  Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4).  Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
What are the official names of this protein?
MAP kinase-activated protein kinase 5, MAPK-activated protein kinase 5, MAPKAP kinase 5, MAPKAP-K5, MAPKAPK-5, MK-5, MK5, p38-regulated/activated protein kinase, PRAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
Protein: DNAA_PHYMT
Sequence: MEKYNYIWEKILKEISKIYSDEVFNETFKNTKKVYKYENEIIFILAENEFIKNKIYKIYLSKINEISKSFFKENLNFKFITKKEIKEEKIDNTNYNIYNYGNLNKKYNFKNFIIGESNKFAFEMSKKISENKEIKINPLYIFGNVGLGKTHLLHSIGNKIIKNNKDKKVLYVKADEFIEDFINQLKEEKIENFKLKYRNIDVLLMDDIQIMSEAKRTQIEFFKLFDYLYLNNKQIVITSDKNTSELKNIMSRLISRFEAGLIIDIKKPDFKHRINILNQKMYEFEIKKIKINKEILELIASCFVNNIREMEGALLRLFNYIQTYSNEIDLNIAKEILKPLLKGKMNNFKNKSYKKEYLEKINIIISSFYNIEINELLGKKKHKKYTLPRHISMYLSKKLYKFSYNEIGKFFKKNHSAISKGCKKIEKNIEQNTEFKKSVDFIIKKIKSKEETEEI
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BMTI3_RHIMP
Sequence: EVHNFACLGKPDPGGCAHYIYRRYYYV
What is the function of this protein?
Inhibits bovine trypsin and human neutrophil elastase.
What are the official names of this protein?
Kunitz-type serine protease inhibitor 3, BmTI-3.
What are the subcellular locations of this protein?
Secreted.
Protein: REV_HV197
Sequence: MAGRRGDSEQQLLTPVRIIKILYQSNPYPKPEGTRQARRNRRRRWRARQRQIREISQRVLSSCLGRSTEPVPLQLPPLERLSLNCDEDSGQGTEGELGSPQIPVEPDTVLGSGDKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: SP2AB_BACHK
Sequence: MRNEMNLQFSALSQNESFARVTVAAFIAQLDPTMEELTEIKTVVSEAVTNAIIHGYEGNAEGVVYISVILEEAMVKLTIRDEGIGIFNLDEARQPLFTTKPELERSGMGFTIMENFMDEVEVISNESFGTTIHLTKYLSNSNALCN
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: DCD_PSEPG
Sequence: MSIKSDKWIRRMAQEHGMIEPFVERQVRGEQDSRVISFGVSSYGYDVRCADEFKVFTNINSATVDPKNFDAGSFVDIKSDVCIIPPNSFALARTVEYFRIPRDVLTICLGKSTYARCGIIVNVTPLEPEWEGHVTLEFSNTTTLPAKIYANEGVAQMLFLQSDEECEVSYKDRGGKYQGQRGVTLPRT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: RBKTP_ROSDO
Sequence: MPGTLFLIVGPSGVGKDTLLEGARDRLATSRWFSFPQRVVTRAADAGGEDYIPVTPSEFEQQLAAGAFWHQWHAHGLSYGIPMQVARDLDNGINVVLNASRNEIGAFRDKATHVVTIGISAPPGIVEERLHERGRESEEEIKRRLARLVEQAPLTGYALEIVNDRTIEEGITALVDLIAGACDLNAEITRFPVTIGSKQVCLVHKGNQIASRVLAGSSRVTLSLRGKSVSAELGETWSDEIVSQDLCALSEGAMAALDAVEGDVVSIERSPTPKSRSILQKKVRGGELSHAEMEAFIHDLVNGRFSTSEIAGFLVAASNNLTMDEVISLTQVRAAFAHRHDWGKAIVVDKHSMGGVPGNRITPIIIPILAAFGLTVPKTSSRAITSAAGTADMMEVLSRVDLSPDEMKSVVEQTNGCIAWNGNLTHSPVDDVMNAINRPLGLQSTLLDVSSIMSKKLAAGSTHVLIDMPVGPKAKTRTQGEAGALKNLFESVGQGIGLNTKVQISDGTKPIGRGVGPVLEALDVLSVLRGEAGAPTDLLDKSIGYAATILEWSGAVSQGQGAQVTRDLVSSGKAFEKLFEIRDAQGRQHDPLQPGQFTEDICADRSGRVEAIDIQGISEVARLSGAPKDKAAGVVLNVQVGDQIAEKQPLLRVHSSSLRGIEEAVCAAQAQSAFKIL
What is the function of this protein?
Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
What are the official names of this protein?
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Protein: DLGP3_MOUSE
Sequence: MRGYHGDRGSHPRPARFADQQHMDVGPAARAPYLLGSREAFSTEPRFCAPRAGLGHLSPEGPLSLSEGPSSVGPEGGPGGVGAGGGSSTFPRMYPGQGPFDTCEDCVGHPQGKGATRLPPTLLDQFEKQLPVQQDGFHTLPYQRGPAGPGPGPGSGAAPEARSESPSRIRHLVHSVQKLFAKSHSLEAPGKRDYNGPKADGRGSSGGDSYSGPGSGGTPTSHHHHHHHHHHHHQSRHGKRSKSKDRKGDGRHQTKATGWWSSDDNLDSDSGFLGGRPPGEPGGPFCLDAPDGSYRDLSFKGRSGGSEGRCLACTGMSMSLDGQSVKRSAWHTMMVSQGRDGYPGAGPGKGLLGPETKAKARTYHYLQVPQDDWGGYPTGGKDGEIPCRRMRSGSYIKAMGDEESGDSDGSPKTSPKALARRFASRRSSSVDTARINCCVPPRIHPRSSIPGYSRSLTTGQLSEEFNQQLEAVCGSVFGELESQAVDALDLPGCFRMRSHSYLRAIQAGCSQDDDCLPLLAAPASVSGRPGSSFNFRKAPPPIPPGSQAPPRISITAQSSTDSAHESFTAAEGPARRCSSADGLDGPTMGARTLELAPVPPRASPKPPTLIIKTIPGREELRSLARQRKWRPSIGVQVETISDSDTENRSRREFHSIGVQVEEDKRRARFKRSNSVTAGVQADLELEGLAGLATVATEDKALQFGRSFQRHASEPQPGPRAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSPGPTPVPAPGPGSGRRDSWMERGSRSLPDSGRTSPCPRDGEWFIKMLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQSLDPTAFPVPTFQDLAGFWDLLQLSIEDVTLKFLELQQLKANSWKLLEPKEEKKVPPPIPKKPSRGRGVPVKERSLDSVDRQRQEARKRLLAAKRAASFRHSSATESADSIEIYIPEAQTRL
What is the function of this protein?
May play a role in the molecular organization of synapses and neuronal cell signaling.  Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton.  May induce enrichment of PSD-95/SAP90 at the plasma membrane.
What are the official names of this protein?
Disks large-associated protein 3, DAP-3, PSD-95/SAP90-binding protein 3, SAP90/PSD-95-associated protein 3, SAPAP3.
What is the protein family that this protein belongs to?
Belongs to the SAPAP family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Postsynaptic density. Synapse. Note=Postsynaptic density of neuronal cells.
Protein: DNER_MOUSE
Sequence: MPPRRAQAPGAPLLPVLALLPLLLGAGPQSGCLASPVSAAPLPAPGPCASQPCRNGGVCTPRSVTDQEHPAADAEPRYSCTCPAGVSGTYCQFVADPCASNPCHHGNCSSSSSSSSDSYLCICNDGYEGLNCEQPLPSIPTSGWTESTAPRQLQPVPATQEPDIILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEVPQNTSVKIRQDANSLLILLWKVTATGFQQCSLIDGRSVTPLQAPGGLVLLEEMLALGPNHFIGFVNDSVAKSIVALRLTLVVKASNCVPGDSHSNDLECSGKGKCATKPSEATFSCTCQDQYIGTFCEEFDACQRKPCQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLDPCRNGATCVSSLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCYVDGVHFTCSCSPGFTGPTCAQLVDFCALSPCAHGMCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLINGYECVCLAEYKGTHCELYKDPCANISCLNGGTCDSEGLNGTCICAPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL
What is the function of this protein?
Mediates neuron-glia interaction during astrocytogenesis.  May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling.
What are the official names of this protein?
Delta and Notch-like epidermal growth factor-related receptor, Brain EGF repeat-containing transmembrane protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region.
Protein: KHSE_BACC3
Sequence: MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIVSTACKVCPSLSPHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVISLIPNEELNTDESRSVLPDVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMEMDHFHEPYRLELVPLLPSIRKCAKEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.