PharMolix/UniProtQA huggingface dataset:
Protein: RSMH_SHESW
Sequence: MSQEFAHLSVLLAETVGGLNIKDDGIYIDGTFGRGGHSRQILQRLGDNGRLIAIDRDPQAIEAAKQFSDDPRFQIVHGGFGQLADYVEDLGLVGKIDGVLLDLGVSSPQLDDAERGFSFLRDGPLDMRMDNSQGQTAAQWLAHAEIEDMAWVFKTYGEEKNARHIARCIAADRDKTPFLRTKDLADLIARITKNKERNKHPATRVFQAIRIYINSELDQIDQALEGALAVLAPQGRLSIISFHSLEDRIVKRFIRRHSQGESVPYGLPITEDQINKSRKLRAIGKAIMPSDEEIERNARARSSVLRIAERLDY
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAX_HTL1C
Sequence: MAHFPGFGQSLLFGYPVYVFGDCVQGDWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVIGSALQFLIPRLPSFPTQRTSKTLKVLTPPITHTTPNIPPSFLQAMRKYSPFRNGYMEPTLGQHLPTLSFPDPGLRPQNLYTLWGGSVVCMYLYQLSPPITWPLLPHVIFCHPGQLGAFLTNVPYKRIEKLLYKISLTTGALIILPEDCLPTTLFQPARAPVTLTAWQNGLLPFHSTLTTPGLIWTFTDGTPMISGPCPKDGQPSLVLQSSSFIFHKFQTKAYHPSFLLSHGLIQYSSFHNLHLLFEEYTNIPISLLFNEKEADDNDHEPQISPGGLEPLSEKHFRETEV
What is the function of this protein?
Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways.  Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE).  Binding to TRE requires the interaction with CREB1 and CREBBP.  Also induces chromatin remodeling of proviral LTR-mediated gene expression by recruiting the histone acetyl transferases CREBBP and EP300 to the chromatin, which results in histone acetylation.  Via its interaction with IKK regulatory subunit IKBKG, Tax-1 persistently stimulates I-kappa-B kinase (IKK), resulting in constitutive activation of the transcription factor NF-kappa-B.  Induction of the nuclear expression of members of the NFkB family of transcription factors, which leads to up-regulated expression of many gene promoters containing NFkB motifs.  These genes include those encoding IL2, IL15, IL2RA and IL15RA, leading to autocrine IL2/IL2RA and IL15/IL15RA loops.  The resulting T-cell proliferation leads to malignant transformation and to the development of adult T-cell leukemia (ATL).  IL13, known to be linked to leukemogenesis, is also up-regulated by Tax-1.  Interaction with PDZ domain-containing proteins induce IL2-independent growth, which may be a factor in multi-step leukemogenesis.  Inhibits the action of at least three cellular tumor suppressors p53/TP53, RB1 and DLG1, and suppresses their abilities to dictate apoptosis in primary cells.  Required for viral replication (By similarity).
What are the official names of this protein?
Protein Tax-1, Protein X-LOR, Protein PX, Trans-activating transcriptional regulatory protein of HTLV-1.
What is the protein family that this protein belongs to?
Belongs to the deltaretrovirus Tax protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Shuttles from the nucleus to the cytoplasm. Found predominantly in the nucleus, where it is equally distributed between the nucleoplasm and the nuclear matrix (By similarity). Colocalizes with host ZFP36 in the nucleus and the cytoplasm in a region surrounding the nucleus (PubMed:14679154).
Protein: MNMA_STAHJ
Sequence: MSNKDIRVVVGMSGGVDSSVTAHVLKDQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIAVCNQIGIPYYAVNFEQEYWDKVFTYFLDEYKKGRTPNPDVMCNKEIKFKAFLEHALKLGADYVATGHYARIRRHDDGHVEMLRGVDNNKDQTYFLNQLSQQQLSKVMFPIGDIDKKEVRKIAEEQDLATAKKKDSTGICFIGERNFKTFLSQYLPAQSGEMRTLNGDKMGMHSGLMYYTIGQRHGLGIGGDGDPWFVVGKNLEDNILYVEQGFHHDALYSDYLIASDFSFVNPVDLDNGFECTAKFRYRQKDTKVFVQRESQNALRVTFDEPVRAITPGQAVVFYDEEVCLGGATIDDVFKTTGQLSYVV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_BIFLD
Sequence: MVKRSKKYREAAERVDRNNLYTANEAIALLKSMPSYNFDQTVEAVFRLSVDPRKADQLVRGTVNLPHGTGKTAKVLVFARGPKATEATEAGADIVGDDDLIAKVQGGFLDFDAVVATPDMMGKVGRLGRVLGPRGLMPNPKTGTVTMDVTKAVKDIKGGKIEFRVDKNGNLSFLIGKMSFDESALDENFKAVADEVKRLKPSTVKGRYLTKATITSTMNPGVPVDPNTLA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: GLRA1_HUMAN
Sequence: MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
What is the function of this protein?
Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860).  Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272).  Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272).  Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753).  Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272).  Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).  Channel activity is potentiated by ethanol (PubMed:25973519).  Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).
What are the official names of this protein?
Glycine receptor subunit alpha-1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Synapse. Perikaryon. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein.
Protein: NRAM_I00A1
Sequence: MNPNQKIITIGSISIAIGIISLMLQIGNIISIWASHSIQTGSQNHTGICNQRIITYENSTWVNHTYVNINNTNVVAGKDKTSVTLAGNSSLCSISGWAIYTKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPLGEAPSPYNSKFESVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITETIKSWKKRILRTQESECVCVNGSCFTIMTDGPSNGAASYKIFKIEKGKVTKSIELNAPNFHYEECSCYPDTGTVMCVCRDNWHGSNRPWVSFNQNLDYQIGYICSGVFGDNPRPKDGEGSCNPVTVDGADGVKGFSYKYGNGVWIGRTKSNRLRKGFEMIWDPNGWTDTDSNFSVKQDVVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELVRGLPRENTTIWTSGSSISFCGVNSDTANWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: 3MGH_BACLD
Sequence: MNPAHEPLPLEFYNKPTIELARSLLGCLLVKETEEGPASGYIVETEAYKGPGDRAAHSYGNRRTKRTEIMYREAGVVYTYTMHTHTLINVVSGGADEPEAVLIRALEPHEGLALMEKRRSGKKPRDWTNGPGKLTKALSITMNDYGRPLTGPPLYIAKGYEPQDILSGPRIGIDNSGEAREYPWRFWIKGNRYVSR
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: OTC_MYCTU
Sequence: MIRHFLRDDDLSPAEQAEVLELAAELKKDPVSRRPLQGPRGVAVIFDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDETLQDTAKVLSRYVDAIVWRTFGQERLDAMASVATVPVINALSDEFHPCQVLADLQTIAERKGALRGLRLSYFGDGANNMAHSLLLGGVTAGIHVTVAAPEGFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGADVLVTDTWTSMGQENDGLDRVKPFRPFQLNSRLLALADSDAIVLHCLPAHRGDEITDAVMDGPASAVWDEAENRLHAQKALLVWLLERS
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C560_DICDI
Sequence: MFGRTLNTFTSRNAPLVRNFDKFIVNNTLTSKNIYLSQTNTTNTPLSYSTQAKKPFTITEKRIDELKTPYQPTSPHLTIYKFPLPAVMSIMHRATGICLALGITGLAGVTLFAPHDAIHYIQLLHTQYPALVYPAKFAVALPLTYHFCTGVRHIIWDETVKGLSISQIESSGKVLLAVVAVLSTIFTFVSFK
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b560 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MINC_HALH5
Sequence: MTTQKKQAVTIKGTKDGLTFHLDDRCSFDSIVGELAEKLSSKHYQMEDQPRIQVKVDVGYRYLTVEQKRHIQELITDGRNLDVEEFVSQVMTKEEAEEKRKEAQIVSVAKVIRSGQVFSVDGDLLLIGDVNPGGTIRASGNIFVIGSLRGIAHAGYKGNGEAVIATSHMAPAQLRIGEQIFHWSKEEQQAGDRIMECAYIASDTNEIQLDRVQKLLKIRPNLATFLDEMVEQ
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization (By similarity).
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: ATPO_BOVIN
Sequence: MAALAVSGLSQQVRCFSTSVVRPFAKLVRPPVQIYGIEGRYATALYSAASKQNKLEQVEKELLRVGQILKEPKMAASLLNPYVKRSVKVKSLSDMTAKEKFSPLTSNLINLLAENGRLTNTPAVISAFSTMMSVHRGEVPCTVTTASALDEATLTELKTVLKSFLSKGQVLKLEVKIDPSIMGGMIVRIGEKYVDMSAKTKIQKLSRAMREIL
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
What are the official names of this protein?
ATP synthase subunit O, mitochondrial, ATP synthase peripheral stalk subunit OSCP, Oligomycin sensitivity conferral protein, OSCP.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: AROB_CAMJR
Sequence: MQVEVKLKENAYKVYIDELEELEFDSKVFILSNPKISGLHLKTLLSKIKAKEIFIATVKDGEEYKNLSTMEEILNQMFNSKLDRKSVLISFGGGVISDMGGFAASIYQRGIDFINIPTTLLACVDAAVGGKTGVNNNFGKNLIGTFYQPKAVYCESFFLKTLSSRELAAGMAEFIKMAAMFDYSILDFIEKIDEKSFLNATCENEIFTQIIAKSIELKSRVVEQDEKESRLRMLLNYGHTFAHVIENFTDYKLYLHGEAVAIGMVMANQLALNLGLLDKMQSQRIKDILLKFGLPISYKINNVDEFYEAFFMDKKSSNKKINFVLASPLGKGLIKGDISKEDIIATLREFQ
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDSA_DICDI
Sequence: MRTDNIRNRKEQLKKQEKKDFDSSKDEETSTSDEEESSGGNRSKIAGKENHQNKNIINQKTNNNNNNNNIKEKDIIDSSVNNADNLKATDPPSAKYKKLAIRSVMGAFMIGFFTIVLSTDHFIVALFVIALQLLVFKEMIALRYIEAKEKKIPHFRTLNWFFLFTSFFFFYAKPILITLANYYPDIFQHFVRYHLWHSFSLYCIGFVLFILTLRKGVYRYQFSQLTWTLMILMMVVVQSNFLISNIYQGLIWFILPVSIIVCNDIFAYFNGFFLGKKFINRPLMKISPNKTWEGFIGATGWTLLFAYYFCGFLLKYDWIVCPKGNTGFMESLHCTRDPVFLEKEFIFPPEITTIAFKYLGITLLPFTYIPIQFHALVLALFGSLIAPFGGFFASGIKRAYKVKDFDTIFPGHGGVTDRTDCQFIMGLFIHVYYNTFIKTLEIDPTFIWQNIMMLSMEEKMVIYEKLKQSIEFTTGTITA
What are the official names of this protein?
Probable phosphatidate cytidylyltransferase, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS21_XYLFT
Sequence: MPSVKVRENEPFEFALRRFKRICEKAGILAETRKREFYEKPTQERKRKAAAAVKRNIRRTSRDVTKRKRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: PP4R2_DROME
Sequence: MVTMENSDEIMQILERFTDLKQKEIPKELEEYLQYVAKTGDTIFKWSSLKYLFREKLLSVIKHFNEDSPRLEEIPNYPNVDPFNYETMKSSLLERLDLFNAAPFTVQRLCELLIDPRKQYSRIDKFMRALEKNILVVSTIDPGRKRTESENGDSLDSVVNGDLSMEVNIDIEMENNNGNADEGSSPGAGSAGCAQKASCPRSDDNDQPKAKKAKLEIDGEERSEASDETDTEVATRVKNEKDEKNDNDETDSPHEAAEIEEPDEEVDEADQETKTTKQPAYGSQKEGEQEESFPSSADDEAEDPMVSKSIEAEKELVAQEKKREEDKKVAIEPKEEIVKKEEVVESDKPDGKVAQLGDKAVVKKSTPPADGENQEPVKVKAENEKEEKKHAPIKTEKQDDIDSTETDDAPSAEKPAEEKIASSESKPKTKSEDDPEAETKKSQPEKTETEAAEKSVSDEKQAAEPNAESENRNDLTTSKATEAAQESVEKSPVEDASSPAVEDLAAATTPQSPLGAADSAAETPPAETGDDSQASPLVAAVTPPVLALNDQPMEDTPAEEEARVSPSATVEEVVMAESANAGAMATEEAAKDDPAAMEIDDTSQEVMMQ
What is the function of this protein?
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) (By similarity).  The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro).
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 regulatory subunit 2, PPP4R2-related protein.
What is the protein family that this protein belongs to?
Belongs to the PPP4R2 family.
Protein: PLXB1_MOUSE
Sequence: MSVLGPVLLQVFWAGCVVTLRSPLPAAFTANGTHLQHLARDPTTGTLYVGATNFLFQLSPGLQLEAVVSTGPVNDSRDCLPPVIPDECPQAQPTNNPNQLLLVSPEALVVCGSVHQGICELRSLGQIRQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLVGEPLLFVGRGYTSRGVGGGIPPITTRALRPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFVRGASAYFLFLRRDLKAPSRAFRAYVSRVCLQDQHYYSYVELPLACQGGRYGLIQAAAVATSKEVARGDVLFAAFSSVAPPTVDWPLSASTGASGTSVLCAFPLDEVDQLANYTRDACYTREGRAENGTKVADIAYDVLSDCAQLPVDTPDAFPCGSDHTPSPMVSCVPLEATPILELPGVQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGRSAAPYSKQSIQPGSPVNRDLTFDGTFEHLYVATQTTLVKVPVAPCAQHLDCDSCLAHRDPYCGWCVLLGRCSRRSECSRDQGPEQWLWSFQPELGCLRVVAVSPANISREERREVFLSVPGLPSLWPGESYFCYFGDQQSPALLTSSGVMCPSPDPSEAPVLQRGADHISVNVELRFGAVVIASTSLSFYDCVAVTASSPSAPCRACVSSRWGCNWCVWQQLCTHKASCDAGPMVASQQSPLLPLIPPARDELTPFPPTVPQTTVTPTPNSFPIEPRAPSTASDVLPGAKPSRLSLWGPWAGPGPILSPTSTESPLHEKPLPPDPPTIPGTTVPAPTGLGPSTTPEDLLASYPFPSDAAAVSPAEPGPEALPSMVALDQPPGTVPDTTFPGAPGSMKPVLDWLTKGGGELPEADEWMGGDTPAFSTSTLLSGDGDSAEHEGPPAPLILLSSLDYQYDTPGLWELGEVNQRVSSCPCVETVQGSLLIPVHVEREVQLRGRNLWLFQDGPRSSECVLELGSREVAVEAQVECAPPPDVWCHIKCQQHQFSYEALKPELQVGLFLRWAGGLRVDSADGLHVVLYDCSVGHGDCSRCQTAMPQYDCVWCEGERPRCVAREACNEAETVATQCPAPLIHSVDPLTGPIDGGTRVTIRGSNLGQHVQDVLDMVRVAGVPCAVDAGEYDVSSSLVCITGASGEEVTGTVAVEVPGRGHGVSEFSFAYQDPKVHSIFPARGPRAGGTRLTLHGSKLLTGRLEDIRVVVGDQPCHLLLEQQSEQLHCETGPYPVPAELPVTVLFGATERRLQHGQFKYTSDPNVTSVGPSKSFFSGGREIWVRGQDLDVVQRPRIRVTVVPRQHGQGLAQKQHVVPEKFEEPCLVNSSHLLMCRTPALPGPPWDSGVQVEFILDNMVFDFAALSPTPFSYEADPTLRSLNPEDPSTPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRNHLYCEPPVEQPLPHPHALREAPDALPEFTVQMGNLRFSLGHVQYDGESPVAFPVAAQVGLGVGTSLLALGVIIIVLIYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERVFFPGYRESPLHRDLGVPDSRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQCVPVKVLDCDTISQAKEKMLDQLYKGVPLAQRPDSCTLDVEWRSGVAGHLILSDEDVTSELQGLWRRLNTLQHYKVPDGATVALVPCLTKHILRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKQMVERYYADIRQTVPASDQEMNSVLAELSRNCSADLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQIAAAVENKVTDL
What is the function of this protein?
Receptor for SEMA4D (PubMed:19788569).  Plays a role in GABAergic synapse development (PubMed:23699507, PubMed:29981480).  Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (PubMed:23699507, PubMed:29981480).  Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (By similarity).  Plays a role in axon guidance, invasive growth and cell migration (By similarity).
What are the official names of this protein?
Plexin-B1.
What is the protein family that this protein belongs to?
Belongs to the plexin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NXRD1_HUMAN
Sequence: MDMLQDLESLQFEYGVPEEDRIWLYLQGRSRGLMIEACAHATFFCKLLYNLRASLNKNQSSRHLSIGSLNSATPEEFKVGIIGGGHLGKQLAGTLLQLGPIPAESLRISTRRPETLGELQKLGIKCFYHNADLVSWADVIFLCCLPSQLPNICVEIYTSLEKASIVYSFVAAIPLPRLKLLLNHTNILRPQYQYDEDSVSVWGANKGVIAALQDPTILQATCPYSPAGGIILNIKWLEGVFYAALNICTARNMAHSQVLQLLSELFLSVHFEDCGKDTASCPKLQLTDFVSKAYGKNLSQERPFPWFDLTAVQLKETPFSQHLSSSPVLQDHLTHLYCASFGISLTKEQPVISTGFPSQ
What is the function of this protein?
Probable oxidoreductase.
What are the official names of this protein?
NADP-dependent oxidoreductase domain-containing protein 1, Pyrroline-5-carboxylate reductase-like protein C14orf148.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
Protein: YSL1_CAEEL
Sequence: MKLLLLALFLSISASCLAEDITKISESRIPNEDAVPDYEAKWRLGAIQKLWNERRKMGHTPMTKFSPPGFPNADIFFKNETATATRTLKHRFAWALLLWAITEGKVTSKTSAVYDSTSGNTGSAEAYMCTLVNVPYYAVVADNLEKEKVKQIESFGGKIIKVPVALRNAKAKEFADKNHGFYMNQFGNAEKAEEFHESGDFYFESTNVYHEIIVQLKKDKEQIVKIPDYFVHSAGTGGTISSVGRYVARYGAPTKVVLSDSQYSLFYDYVIGHKFTNQSGAGIWTPPGIAGIGYGYDIEPVWYGETTSLTRNVIHEAMKMPDIASVATMRILDEKGYNVGPSTSLNFLVSLYKAYQNKARKSAIKHRLTIVTLACDPGDFYRSTYLNNEWVEKSFKKFGGVMGMECWKKLIQESIDTGSDFYSKGLTMCPGAFKV
What are the official names of this protein?
Putative pyridoxal-phosphate dependent protein F13B12.4.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family. Highly divergent.
Protein: DXR_GLOVI
Sequence: MKHIALLGSTGSIGTQTLDIVAEYPERFAVTGMTAHSNMELLAEQIRRFRPQVVAVGSEARRAALAALLAGFDGMPEMFVGEKGCCTVASQAPAEVVVTGIVGCAGLMPTLAAVDAGRDLALANKETLVAGGPVVMPRIRARGVKLLPVDSEHSAIFQCLQGVPEGALKRILLTASGGAFRDWPVEKLAEATTADALKHPNWVMGAKITVDSATLMNKGLEVIEAHWLFGLDYDRIEIVIHPQSIVHSLVELADTSVVAQLGWPDMRLPILYALSWPERLATPWKPLDLARVGTLTFKEPDHERYPNMRLAYQAGRAGGTYPTVLNAANEEAVAQFLQEKVRFLEMSRLLEATLEAHKSAGEPDLDDVCGADRWAREHVRWLVERSPARVLI
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: EFP_LACLS
Sequence: MVLAKDLKSGMTFLNGEKLLRVMEASHHKPGKGNTIMRMKLKDVRSGSTFDDTYRPEDKFEQAVIETVTAQYLYSMDDIANFMNNETYEQYEIPVEQVKDELLYVLENTDVKIQFYGTEVIGIQLPTTVVLEVTETQPSIKGATVTGSGKPATMETGLVVNVPDFVEVGTKLEINTQTGEYLKRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FK106_ARATH
Sequence: MISQEEVPQSTNHSLSFSSLPHEIVVSCLARVSGSYYPKLCLVSKQFRSIILSNEIYKARSHLGTKENRLFVWLKLPTRSYPSWFALWIKPNETLTNDGPIKKQSTGNLLVPLPCSYNYQVLVPSVIVGSETYIVGGYDDALSSSVWFYKNGKIHTLSKSPSMSVARIDAVVVGQYPNIYVMGGCDSDESMNWGEVFNIKTQTWEPLPDPGPEVRGQLVRKMKMQKKNVYVSSEKKDYIYDTEERTWKVTEAVFNFSWCVIEKVRYIYYNKNCWWLDTKSKDWRKIKGLDFLNKFRETDRIEIVNLDGKLVMIWDRFTLSKRNKKIWCAMIALEKCQGCEGIWGKIEWIGDVLMVPLSYSFLDCMVISI
What are the official names of this protein?
Putative F-box/kelch-repeat protein At4g39760.
Protein: SECY2_STRGN
Sequence: MKSFFKPLILKKFLWTLLFVFIYVLGSKLTLPFVDVSSIAKLNGDSVTLNYAAALMGGNLRSMSFFSIGLAPWMSSILIWQMFTVSKRLGLNKLSMESQEKRRMLLTLAIALIQSLGLVLNLPLKTVAGVGQGTIVFLDTLILIAGTYFLIWLTDLNSSMGLGGSIMIVMVSMISYIPQDIWLSIQELKISPLILALIGFFSLCFLYLAVLVERAKYRIPINKINIHNRFKKYSYLDIRVNAAGGLPIMYAMTLVSIPQYFLMLLLFFQPNNRLLKEGILSLAMGGIPWFILYLLTIFILAWAFAFINVNSDQIAERMQRSGEYIENLYPGEATRRYIHKTVGYFAFVGALYLVLVAGLPMLLIFLDIRYMRLGMIPGMFMIFIGMVFSIKDEVDTLTLNDRYHSLF
What is the function of this protein?
The central subunit of a protein translocation channel (Potential).  Part of the accessory SecA2/SecY2 system specifically required to export GspB, a serine-rich repeat cell wall protein encoded upstream in the same operon.
What are the official names of this protein?
Accessory Sec system protein translocase subunit SecY2.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family. SecY2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.