PharMolix/UniProtQA huggingface dataset:
Protein: FLGH_THIDA
Sequence: MKTTRAIAMLGLLLGLAACGTTPSTIVERPTTARPQAPAAVPATNGAIYQAATYRPLFEDRRARHVGDVLTIVINERTRAGKEASSSASKTSAVDASVGGVAKLPLKMFQGLGINAEASAEYEDESALDSSNTFSGNVTVTVIEVLPNGNLVVAGEKQIGLDKGTEYIRLSGVVQPDTIQAGNTVSSAKVADARIEYRSSAKFDKAEVMNWLGRFFLSFIPL
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: CD40L_MOUSE
Sequence: MIETYSQPSPRSVATGLPASMKIFMYLLTVFLITQMIGSVLFAVYLHRRLDKVEEEVNLHEDFVFIKKLKRCNKGEGSLSLLNCEEMRRQFEDLVKDITLNKEEKKENSFEMQRGDEDPQIAAHVVSEANSNAASVLQWAKKGYYTMKSNLVMLENGKQLTVKREGLYYVYTQVTFCSNREPSSQRPFIVGLWLKPSSGSERILLKAANTHSSSQLCEQQSVHLGGVFELQAGASVFVNVTEASQVIHRVGFSSFGLLKL
What is the function of this protein?
Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
What are the official names of this protein?
CD40 ligand, CD40-L, T-cell antigen Gp39, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cell surface. SUBCELLULAR LOCATION: [CD40 ligand, soluble form]: Secreted. Note=Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
Protein: OAT1_STAAS
Sequence: MNSIIELTDYYSSNNYAPLKLVISKGKGVKVWDTDGKQYIDCISGFSVANQGHCHPTIVKAMTEQASKLSIISRVLYSDNLGKWEEKICHLAKKDKVLPLNSGTEAVEAAIKIARKWGSEVKGITDGQVEIIAMNNNFHGRTLGSLSLSNHDAYKAGFHPLLQGTTTVDFGDIEQLTQAISPNTAAIILEPIQGEGGVNIPPKGYIQAVRQLCDKHQILLIADEIQVGLGRTGKWFAMEWEQVVPDIYILGKALGGGLYPVSAVLANNDVMRVLTPGTHGSTFGGNPLAIAISTAALDVLKDEQLVERSERLGSFLLKALLQLKHPSIKEIRGRGLFIGIELNTDAAPFVDQLIQRGILCKDTHRTIIRLSPPLVIDKEEIHQIVAAFQDVFKN
What is the function of this protein?
Catalyzes the interconversion of ornithine to glutamate semialdehyde.
What are the official names of this protein?
Ornithine aminotransferase 1, OAT 1, Ornithine--oxo-acid aminotransferase 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR8_TUPAK
Sequence: MIYDTISDMLTRIRNAYLVKHETVYVLNTKINRKISEILKKEGYIESVNLSTNSLQKLEITLKYLGNQKKPGITNLKRLSWPGLRFYSNYKDIPPVLNGMGVVILSTSKGIMTDREARANKVGGELLCSIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SPED_HAHCH
Sequence: MSEKLKLHGFNNLTKSLSFNIYDICYAQSEKHRQEYIAYIDEQYNAERLTQILTDVVEIIGAHILNVSRQDYDPHGASVTMLIAEHEVPPPADSSEESPGPLPDAVVAHLDKSHVTVHTYPESHPDNGISTFRADIDVSTCGLISPLKALNYLIHSFDSDIVTIDYRVRGFTRDIDGAKLYIDHDINSIQNFLSEDTQEAYQMIDVNVYQENLFHTKMILKEFNLDNYLFGTGVSELNANEASNIRERLQKEMLEIFYSRNMPY
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: RS17E_METPE
Sequence: MGIKPSYIKNFGLELIGRYGDRFTPDFDENKHQVSELTVIDSKRVRNRIAGFITRKVNTKKHL
What are the official names of this protein?
30S ribosomal protein S17e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS17 family.
Protein: PE2R1_MOUSE
Sequence: MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL
What is the function of this protein?
Receptor for prostaglandin E2 (PGE2).  The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system.  May play a role as an important modulator of renal function.  Implicated the smooth muscle contractile response to PGE2 in various tissues.
What are the official names of this protein?
Prostaglandin E2 receptor EP1 subtype, PGE receptor EP1 subtype, PGE2 receptor EP1 subtype, Prostanoid EP1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL4_BORBU
Sequence: MERKVFSKDGKEIGTINLDDRVFNIEISHGSIYNAIKNELSNLRVGTSSTKTRSEVRGSSKKPWKQKGTGRARVGTKRNPVWIGGGIALGPKPRDYSYRLPKKVKKLAFKSVLSLRAADENSFKVIENFNVESGKTKDLALIIKNFASFNGKVVILLGNDDQMIKRAGKNIRDLKILSFDKLRVVDLFYAKNLIALESAVNKLNEFYIK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: SERC_SHEPW
Sequence: MSATFNFCAGPAMLPKPVMDKAQSELLDWNSMGTSVMEISHRSKEFIALTNQAEADLRQLMDIPANYHVLFMHGGGRGQFSAIANNFLGDKGRALYLVDGSWSSAAVEEAKKLVGEENIDTINIVENNNGINSVVLPSLSNIDKDYRYLHYCPNETVDGIEIFDTINSPWPVIADMSSNILSRKIDVNQFALIYAGAQKNIGPSGLSIVIVRNDMLSLPSLPQSSIMDYKLAVKHGSMYNTPPTFAWYLAAEVFAWLKVSGGVDSVELINIEKAMRLYQCIDELDFYKSGVAVENRSRMNVTFQLVNAELDNQFLEEAKQAGLVALKGHRSVGGMRASIYNAMPIEGVIELVKFMQTFAKKHS
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_ACIBC
Sequence: MKKATQSKAWTTVQIARHPERPQFLDYVGEIFTEFDALHGDRLFGDDGAMVGGLARFDGQPVMVIGQHRGRSTREKLKHNFGMCNPEGYRKSQRLLDMAERFNLPVFTFIDTMGAYPGVGAEERGQAEAIATSLAQLSSLKVPVIATVLGEGGSGGALGIGVADRVIMLSHSIYSVISPEGCASILWKTAEKAAQASEALGLTADKLQSLGIVEYVVDEGEGAHLDPERVMQNLKVVLKQALDELLPMDANERCEARYQRLMKFGSENLGVAS
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIM23_BOVIN
Sequence: MEGGGGSGNKTTGGLAGFFGAGGAGYSHADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGAARGGLAGLTLTGLYALYNNWEHMKGSVLQQSL
What is the function of this protein?
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim23.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ADR1_CAEEL
Sequence: MDQNPNYNFGYGQAYGSGTDHTSDSTNNYNWASQWSQPESAASLATHTFPQYVSQQQQQQQQQAQQQAQNTYAAMNPISTFMQQQQRAQTFPQKKYGQQGGAPKPSAIRNNNFGAFGGGHALSQEWVQPMSQNQMGGPQGNRFFNNQKGGPFNQNKPNWRQNKPKGPAAPKKFDSTGKSPAMLLHELFKDVSEEYTEVEGVPKKYCCTLKVNGRTFQMESVNKKAAKQKCSELVVRDLRPDVHVTPFEEGVAAKAAAPVKKEIDAASGNGQNNKRNLLQADAISNQPTPKKVSAVKKAKLQLTPVESALSLLDLMQKIIAESAEKYSPVFEASEVPKDPEIPEVEVKKEEVDTNGENVANEKKSGWRKNETMHNVTLKFVEQNKQYTKMGPSRGVLKDMVIREALRDLFNVSHADITTVARRHASNRLGHDTTILQCLNTICSILNCTLTIECEPAEDRPLGIGRAYFMAKCTIIDHNENDLKFEVKSSSLASKAMAKDWVAQETLKNYFAIDPSSCVKTDAVSSQGPCALLHAMLNKQTKQKCKIAYEFKDNVPPVAGQATTTFYCECVIDETDRYIGVGRSKKLAKSEAAMQALKKLFKIDYDPAGNYPLALTSRAMTESKVSPLCRHIAEFCKREYHQMTEYYQIPPSNLFAAFLLVNAQEEKRVLAMGSSIQYIVEPDTLSGANGTSLLHLDAIILARRAMLKAFIHELSTVDSECSIFEKKEEGKAALKPNLRLVLYSNYSPPCIHAVDDAATKKLSYVTPTNLTCVPDDVLTYEQIKETKSLRVHCTADKLFKWNTLGIQGALLSNVLHPIFIDNIFFGSEAPVSDESLSYALQGRLGPNENEREIIVESMPVQMRMHMGISHLWHRGVDSVETLDYNTGRTSKGSPSRVCKAEIFEAYRKLNGVDQAVVNYAKAKEMASEYQYEKKVFYEKLEAAGLGKWQTKPAELVDSFTLAAFD
What is the function of this protein?
Required for the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12426375).  Does not have deaminase activity but binds to dsRNA and regulates A-to-I RNA editing, possibly by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 for target adenosines (PubMed:24508457, PubMed:25373143).  Regulates editing efficiency of specific adenosines in 3' untranslated regions of target mRNAs (PubMed:24508457).  Represses editing efficiency of the Y75B8A. 8 3' UTR in neurons (PubMed:26917557).  Required for correct expression and A-to-I editing of clec-41 (PubMed:28925356).  Required for normal chemotaxis (PubMed:12426375, PubMed:14657490).  Also required for normal vulva development (PubMed:12426375).  Plays a role in determining lifespan (PubMed:20011587, PubMed:25373143).  Not required for RNA interference (PubMed:12419225).  Likely to play a role in determining whether a dsRNA enters the RNAi pathway (PubMed:14657490).
What are the official names of this protein?
A-to-I RNA editing regulator adr-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Detected both in the nuclear fraction and in the ribosome-containing pellet of the cytoplasm.
Protein: TNAA2_SYMTH
Sequence: MPKGEPFKIKMVEPIRLIPREDREAAIKAAHYNPFLLRSSDVYIDLLTDSGTGAMSQFQWSAMMLGDESYAGASSYYRLKEAVTDITGYEYVLPTHQGRGAEKSAFAQLITRPGMYVLSNMFFDTTRGHVQLAGGRPIDLLLDVPTEEYHPFKGNMDTARLEAFIQEHGAENIACIVMTVTNNSAGGQPVSMANIRETSRIARKYGILLLFDVARYAENCHFIRMREEGYADKAPIDIAREMFSYGDGLMMSAKKDALVNIGGLLAFKDEELYTRVGGTVVPFEGFLTYGGLAGRDLEAMAVGLREALDPDYLAYRVGQVEYLGNLLRSAGIPIQWPVGGHAVFIDAAKFLPHIPWDQFPGHALTVALYQEGGVRTVEVGSLVMGRDPETGENVRSPFEFTRLAIPRRVYTNLHLEDVAETVINAFQKREQIRGVKFTREPKVLRHFTAHFDLV
What are the official names of this protein?
Tryptophanase 2, L-tryptophan indole-lyase 2, TNase 2.
What is the protein family that this protein belongs to?
Belongs to the beta-eliminating lyase family.
Protein: DEF_ECO7I
Sequence: MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEAEGLLAICIQHEMDHLVGKLFMDYLSPLKQQRIRQKVEKLDRLKARA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: PHL3_BACCE
Sequence: MKGKLLKGVLSLGVGLGALYSGTSAQAEASTNQNDTLKVMTHNVYMLSTNLYPNWGQTERADLFGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNYSSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENNNDSEYASMFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSLAEYLDYIIASKDHANPSYIENKVLQPKSPQWTVTSWFKNIRIMITLIIIQVEATISMK
What is the function of this protein?
Required, with sphingomyelinase, to effect target cell lysis (hemolysis).
What are the official names of this protein?
Sphingomyelinase C, SMase, Cereolysin B, SMPLC, Sphingomyelin phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the neutral sphingomyelinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: APT_MARSD
Sequence: MNLRDYIRDIPDFPKEGIVYFDITPLLAEPKAFQYTIDQLAERFADYKIDKIAAAEARGFIFGAPLATKLDIGFVPIRKPGKLPYETISVSYDLEYGTDNLSMHVDAVAKDENVLLIDDVLATGGTAEGMVKLVEKAGGKVSGMGFIAELTFLDGKSKLSGIDTTSLIQL
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_VAMBR
Sequence: MTNIRKTHPLLKIINSSFVDLPAPSSLSSWWNFGSLLGVCLGVQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWLLRYLHANGASMFFICLYLHVGRGLYYGSYTYSETWNVGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTELVQWIWGGFSVDKATLTRFFAFHFLLPFIITALVMVHLLFLHETGSNNPTGIPSDPDMIPFHPYYTIKDILGFLIMLTALSALVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPILHMSKQRSMMFRPLSQCLFWLLVAVLFTLTWIGGQPVEYPYIIIGQTASVLYFLIILVLMPAVSLMENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VATA2_CLOTE
Sequence: MVLLDSLVGTIVGINGPVIKAEGMSKFKMREMVMVGKKKLIGEIIILENDLATIQVYEETSGLKIGENISSTGMPLSLKLGPGIIGNMFDGIQRPLKKINEISYGFIDEGIGLISIDEEKEWDVNIVVKVGDKLKPGDVYAEVQETNIIKHRIMVPQDVNGEVTKVKESGKYNIEEKIVTVKDGGNIYELNLYQRWPVRTPRPIKNRLSLGKPLITGQRILDMFFPIAKGGTVAIPGGFGTGKTMTQHQLAKWSDADIIVYIGCGERGNEMTEVLEDFPKLIDPKTNTSLMNRTVLIANTSNMPVAAREASIYTGITIAEYYRDMGYDVAIMADSTSRWAEALREISGRLEEMPAEEGYPAYLPSRIAEFYERAGYVENLNDTEGSVTVIGAVSPAGADFSEPVTQNTKRFVGAFLGLDRKLAYARHYPAINWLTSYSQYNVMLTDWYLENISEDIIELRNKMLKILFEENKLQEIVKLVGEDVLPDDQRLILEVARILKVGFLQQNAYHDEDTYVPKEKQYKMLKAIELFYDNAYKCVKMGIPISKIRNEEIFGDLIKMKYNIPNEDISGIKVIEEKISSYYEELIEQYRK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain 2, V-ATPase subunit A 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: YH5A_SCHPO
Sequence: MPSKEIDINQKKNVLPKPEDIQLIICDVDGTLLGPDHKPHPRNLRALKYLRENYPQLPFVLATGRQRTSVGNIREALGLHVFPCVHLNGCVVYDKGEIVACAALKNSLAIDIIDKLKDIQTCALFGYDEDYVYQIKQESDKKQHGIKFLRLCGETVKDDANEMLPQLKGPKDIFNKMVVFDDDTNGLEEAKKRLAGIPSDEVALTQALPQTFEIIPPNDNKGVALKNILSKIYPSISLENVLAFGDGANDVCMFELAGYSVAIRSGMPVALKAAKAISDVSSAEGAVGEVLERIYNIPPDFN
What are the official names of this protein?
Uncharacterized hydrolase C215.10.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRHO_STRS2
Sequence: MSKDIRVLLYYKYVPIENAKEYAAEHLAFCKSIGLKGRILIADEGINGTVSGDYETTQKYMDYVHANPLFSDLWFKIDEENEQAFKKMFVRYKKEIVHLGLEDNDFDNDIDPLVTTGAYLSPKEFKEALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVRGELWDGKMYVFDERIAVDVNHVNPVVVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEHKYVRGCSAECRAHERNRYISENGLTRQEWAERLEAIGETLTPANA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: NECA2_MOUSE
Sequence: MCERAARLCRAGAHRLLREPPPQGRALGGLLRWVGARMGEPRAPLVPDIPSADPGPGPAASRGGTAVILDIFRRADKNDDGKLSLEEFQLFFADGVLNEKELEGLFHTIDSDNTNHVDTKELCDYFVEHMGDYEDVLASLETLNHSVLKAMGYTKKVYEGGSNVDQFVTRFLLKETANQIQSLLSSVESAVEAIEEQTSQIRQDHCKPSHAVNESRYGGPTPPYIPNHKLVAPEPMKSLPVATGEPKEDGLEGQISRLAELIGRLESKTLSFDLQQRLSDEEGTNMHLQLVRQEMAVCPEQLSEFLDSLRQYLRSTAEERNCFHVAAVRMADGLTFVIYEFWETEEEWKRHLQSPVCKAFRHVKVDTLSQPEALSQISVPAAWCTSGRD
What is the function of this protein?
May act as a signaling scaffold protein that senses intracellular calcium.  Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
What are the official names of this protein?
N-terminal EF-hand calcium-binding protein 2, EF-hand calcium-binding protein 2, Neuronal calcium-binding protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, dendrite. Cell projection, axon. Cell membrane. Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (By similarity). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity).
Protein: MEL6_YEASX
Sequence: MFAFYFLTACISLKGVFGVSPSYNGLGLTPQMGWDNWNTFACDVSEQLLLDTADRISDLGLKDMGYKYVILDDCWSSGRDSDGFLVADKHKFPNGMGHVADHLHNNSFLFGMYSSAGEYTCAGYPGSLGREEEDAQFFANNRVDYLKYDNCYNKGQFGTPDVSYHRYKAMSDALNKTGRPIFYSLCNWGQDLTFYWGSGIANSWRMSGDITAEFTRPDSRCPCDGDEYDCKYAGFHCSIMNILNKAAPMGQNAGVGGWNDLDNLEVGVGNLTDDEEKAHFSMWAMVKSPLIIGADVNHLKASSYSIYSQASVIAINQDPKGIPATRVWRYYVSDTDEYGQGEIQMWSGPLDNGDQVVALLNGGSVARPMNTTLEEIFFDSNLGSKELTSTWDIYDLWANRVDNSTASAILEQNKAATGILYNATEQSYKDGLSKNDTRLFGQKIGSLSPNAILNTTVPAHGIAFYRLRPSA
What are the official names of this protein?
Alpha-galactosidase 6, Alpha-D-galactoside galactohydrolase 6, Melibiase 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYAY_VIBCM
Sequence: MNETEFHQLVDSQLERIEAAIDEAGADIDYETSGNVMTLEFDDGSQIIINRQEPMREIWLASKSGGYHFKSIDGEWICSKTGLELLTLLKQECDKHADEPIDWV
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: YQGF_XANCB
Sequence: MPEAGAIRPDATVLGFDVGSRRIGVAVGTALGAGARAVAVINVHANGPDWVALDRVHKEWRPAGLVVGDPLTLDDKDQPARKRAHAFARELRERYALPVVLIDERSSSVEAAQRFARERADGRKRRRDADALDAMAAAVIVERWLSAPEQATLLP
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_THISH
Sequence: MKLLYDLLPVILFFLAYKFYGALPPEWILAVGVWLPVALEPDNPGHAIYLATAVAMVVMAVQLALGLAIKRRLETMPLLTAAVILVLGGATLWLHDPVFILWKPTLVNWLFALVFMAPPLFGRRTLVETLMGHALSVPRAIWSRVNLAWVVFFLVSGLANLFVAYTFSEAVWVDFKLFGMLGMTFVFVIGQAVYLGLHHREDDPHTTKGDPS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS9_STRP2
Sequence: MSQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADLRLVINQPFAVTSTVGSYDVFVNVVGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAGLLTRDSRKVERKKPGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RLMH_THEYD
Sequence: MYRFKIYYPGKTKAKFIKEGIDHYIKLLSPFAKVELIELKEGHGDKEKVTEEESKTILNSLKGDFILLHRDGKSLSSTEFADFIKDKSLTQFVIGGVYGVNEAVFKAASFRLSLSSLTFTHEISRLLLLEQLYRAITIIHGKSYHY
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CF120_XENTR
Sequence: MVEYWKRNFFMVLVLQAFYLANCLTDEEIPEEWLLLHVLQGQIGAGNYSYLRLNHEGTIILQVQSLKGDADIYVSSLTLNPTFDDYELQSTTCGLDKITIAHHLSRPVGIGIYGHPSHMESEFELKVYYDRTVREDPFADASYDPEVLEAKQRQQQQQTSLDSSQEEESVLRTILIGVLKIVLELLF
What are the official names of this protein?
UPF0669 protein C6orf120 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0669 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYT_SHEPC
Sequence: MPVITLPDGSKREFAHAVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSIITAKDEEGVEILRHSCAHLLGHAIKQMWPETKMAIGPVIDNGFYYDIDLEHKLTQDDIEALEKRMLQLAKTNYDVVKRVVSWQEARDTFAARGEEYKIAILDENISKDATPALYHHEEYTDMCRGPHVPNMRFCQHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLTRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMDRVLWERSGHWDKYSEAMFTTSSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTDDQVQEEVSACIQMVYDTYSTFGFENIVVKLSTRPEKRIGDDAMWDRAEEALKQALRANNIEFTLLPGEGAFYGPKIEFTLHDCLDRAWQCGTVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPMQVVVMNITDKQADYVQEIVKFFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENKEVAVRTRDGIDLGKMRLEDFATKIHQQISLRSLKLLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.