PharMolix/UniProtQA huggingface dataset:
Protein: RS12_VIBCM
Sequence: MATINQLVRKPRAKQVVKSNVPALAACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGALDCAGVNDRKQARSKYGVKRPKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SYGA_RICM5
Sequence: MKKLSFQQIILTLQNYWQDYGCAILQPYDAHVGAGTFHPATVLRCLGTKPWSVAYVQPSRRPGDSRYGMHPNRMQHYYQFQVILKPSPDNIQELYLKSLECLGIDLKIHDIRFVEDDWESPTLGAAGLGWEVWCNGMEVSQFTYMQQIGGIECRPVAGEITYGLDRLALYIQGVDEVRELDWNGQVGEKALKYGEVDFEAERQFSKYNLELADSEMLLRHFKDSEDQCERLIKANLPMPAYDECLKASHAFNQLNALGVISVTERASYVLRVRHLARICCTKWLEMNK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDIA5_RAT
Sequence: MARAWGLLLAIGVILPTWLSSTKVSSLIERISDPKDLKKLLRTRNNVLVLYSESEVAAESHLKLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKIELFHYQDGAFHMQYDRAVTLKSIVAFLKDPKGPPLWEEDPGAKDVVHIDSEKDFRRLLKKEEKPLLMMFYAPWCSMCKRIMPHFQKAATQVRGHTVLAGMNVYPPEFENIKEEYNVRGYPTICYFEKGRFLFQYENYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFESAAEVLHGDAESSGVLAAVDATINEALAERFHISAFPTLKYFKNGEQQAVPALRTKKKFIEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQESVKAYPTFHYYHYGKLVEKYESDRTELGFTSFIRTLREGDLKRLEKRREDL
What are the official names of this protein?
Protein disulfide-isomerase A5.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: RPIA_AZOSB
Sequence: MTQDELKKAAALAALDYVEDGMIVGVGTGSTVNHFIDGLAGIKHRIRGAVSSSEASSKRLAAHGIALLDLNDVDELPVYIDGADEIDHGFAMIKGGGGALTREKIVAAVARRFVCICDESKRVDVLGRFPLPIEVIPMARSQVMRAAAALGATPRLREGFVTDNGNLIIDLHGLSITDPCATEQALNAVVGVVTNGLFAARGADTLLLASAQGVRRFERSAT
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: RS8_RHOCS
Sequence: MNLSDPLGDMLTRIRNGQKARMSVITSPASKLRTNVLEVLKREGYIRGYNVEDVRPGVRNLRIELKYHEGEPVIKEIHRVSKPGRRIYSKIADLPRVYNGLGIAILSTPRGVMSDAEARAANVGGEVLCKVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: MDM10_ZYGRC
Sequence: MLDYMDYVQRQFEKSTDWNYDNSYANILASSRNILDFPVPNQFKFQLSNNSTPHTFNTMEVFSRKIFNGSMTYLYTDAENMDKLVHDSNSISLQDVTDTYRYVQPYYTHKPSSNGDNHVRSLYYGKMSYPSPNLEAMLIKRLNESTQLTLQCVSSFNGFNILTGYWQHDTGRNRHEVIMSTNDLLCGYRYLHNFLGTPSKLKTSLYNNFSLSLGGEVWLGIVTLSPGCSTTLRYCTHSPTTGRPQTLTLTWNPLFGHISSTYTAKTSSSSTFSTKYDFNLYSIESNLSFGCEFWRRGYQESSPQLQEQINGHASEPKDRIMYYHMMAPDSRNSISPRANSPQERQLLEDLTIAFSSSLKKIDKEKSMIEQFENRINQSNFTSVWKLSTSSKDKNLRLLWEGKFKGFLLSAGTEFCKTNPRNEINEVPSTENKLTFYPNKFGIQLQYST
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange.  MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex).  Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins.  Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins.  May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway.  Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 10, Mitochondrial inheritance component MDM10.
What is the protein family that this protein belongs to?
Belongs to the MDM10 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: SYC_SULDN
Sequence: MFIFDSAKKIKREFIPQEQGKVSLYVCGPTVYDDAHLGHAKSALVFDLLCRVLNANGYEVTYARNITDIDDKIINRAQEQNKTIKEVTDFYTDAYHKEMALLGISRPDIEPKATESLDAMYALVQKLLDNKHAYTTDDGDVYFDTSSDSKYLTLSNRVQDESEKLQRVQSSSQKRNPADFALWKSIHDESVTFGSPFGKGRPGWHLECSAMIEKHLSKPNAKFAVDIHGGGADLLFPHHENEAAQTRCATDHALAAYWMHNGFVNIDGEKMSKSLGNSFFLKDALKIYDGEVLRFYLLSTHYRSNFNFNEEDLATAKKRLDKIYRLKKRLFGVTYEDEKTDFKKELLETLSDDLNISASLALIEEMITRANETLDTAGKHKELKREALSNLSFIEKILGFGIKNPYEYFQFGVNEETKTEIAKLIEKRAEAKKSKDFAASDMLRDKILAYGVNLMDTPQGSFWEKI
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPIA_CHLPN
Sequence: MEKDLHLHEKKCLAHEAATQVTSGMILGLGSGSTAKEFIFALAHRIQTESLAVHAIASSQNSYALAKQLAIPLLNPEKFSSLDLTVDGADEVDPQLRMIKGGGGAIFREKILLRAAKRSIILVDESKLVPVLGKFRVPLEISRFGRSAIIEEIRHLGYEGEWRLQDTGDLFITDSSNYIYDIFSPNSYPNPEKDLLKLIQIHGVIEVGFVIEKVEVWSSNSQGLISKKYSV
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: SYP_BACVZ
Sequence: MRQSLTLIPTLREVPADAEAKSHKLLLRAGFIRQNTSGVYSYMPLAYRVIQNIQKIVREEMEKINAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGREFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDAYSFHASEESLEETYQNMYGAYSSIFARCELNVRPVIADSGAMGGKDTHEFMALSEIGEDTIAYSDGSSYAANTEMAEVVMNSEPSDETPEALEKIDTPNVKSIEELASFLQIEPSACIKSMLFKADDRFVLVLVRGDHEVNDVKVKNLLNAEVVELASHEEVAEKLGTEPGFAGPIGAAGDIEIYADQAVKVMVNAVSGANEKDRHYRNVNIERDASVKAYADLRIIQEGDPSPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLSAIAEQHHDEKGLIWPKSVAPYDLHILALNMKNEAQKELAEQLYGKFQAEGYEVLYDDRAERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRKTGESAEVSVDELSEFIKTK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_BUCBP
Sequence: MTKEDCIEMQGVVIDTLPNTMFRVQLDNKHIVTAHISGKMRKNYIRILTGDKVTLELTPYDLSKGRIIFRSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEPF_MYCTO
Sequence: MSTLHKVKAYFGMAPMEDYDDEYYDDRAPSRGYARPRFDDDYGRYDGRDYDDARSDSRGDLRGEPADYPPPGYRGGYADEPRFRPREFDRAEMTRPRFGSWLRNSTRGALAMDPRRMAMMFEDGHPLSKITTLRPKDYSEARTIGERFRDGSPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSPEERRRIAETGFYAYQ
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: ACT_CANDC
Sequence: MDGEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSLVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILTLRYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHGILRIDLAGRDLTNHLSKILSERGYSFTTSAEREIVRDIKERLCYVALDFEQEMQTSSQSSAIEKSYELPDGQVITIGNERFRAPEALFRPADLGLEAAGIDQTTFNSIMKCDMDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHHKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: VITA1_XENLA
Sequence: MRGIILALLLAIAGSERTQIEPVFSESKTSVYNYEAVILNGFPESGLSRAGIKINCKVEISAYAQRSYFLK
What is the function of this protein?
Precursor of the major egg-yolk proteins that are sources of nutrients during early development of oviparous organisms.
What are the official names of this protein?
Vitellogenin-A1, VTG A1.
Protein: CPSF5_BOVIN
Sequence: MSVVPPNRSQTGWPRGVTQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN
What is the function of this protein?
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs.  CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals).  Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation.  The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.  NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7.  Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing.  The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA.  Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function.  Binds to chromatin.  Binds to, but does not hydrolyze mono- and di-adenosine nucleotides.
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 5, Nucleoside diphosphate-linked moiety X motif 21, Nudix motif 21.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. CPSF5 subfamily.
Protein: XYLB_STAXY
Sequence: MAYVIGIDIGTSALKTLVVNKSGDVVESYSVSYNTAHPKSGYSEIDPEIWYEATLESLKYILNHYTHNDLTGISFSGQMHGLVVIDQEGNPIRPAILWNDTRTSQEVEDIKKNLGLNSLLQLTQNTVLEGFTLPKLMWLKNHEQDNYKRIYKFMLPKDYIVYKLTGNVYTEPSDAAGTIMFSVKDENWSTELLHRLNIDPSICPEIIASHQKSGQLTEKVKNTLGIDSNINVYQGGANNACGALGSGITDEQKQLVSIGTSGVALSIENSTDYENDGNVHYFNHCVPNQKYIMGVTLSAGYSLEWLKQLISADENFTTFLKDINQSEVGANGLMYTPYLLGERTPHNDASVRGSFIGLDANTTQLDMKRAVIEGITYSINESIHIMKNNAININEIVSIGGGAKNNQWLQIQADIFNTTITTRTEEQGPAYGAAMIAAMGEQWFNTFNEMSEAWIAYHQKVYPIETNTKSYQDLFNIYKTIYD
What is the function of this protein?
Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.
What are the official names of this protein?
Xylulose kinase, Xylulokinase.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RR17_NEOYE
Sequence: MPLKETTGKVVSDKMNKTIVVAVENRISHRKYAKTMIRTKKYKAHDENNECTIGDIVTIQETRPLSRTKCWTMVNILSKSFDN
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: OR1D5_PANPA
Sequence: MDGDNQSENSQFLLLGISESPEQQQILFWMFLSMYLVTVLGNVLIILAISSDSHLHTPMYFFLANLSFTDLFFVTNTIPKMLVNFQSQNKAISYAGCLTQLYFLVSLVTLDNLILAVMAYDRYVAICCPLHYVTAMSPGLCVLLLSLCWGLSVLYGLLLTLLLTRVTFCGPREIHYLFCDMYILLRLACSNTHIIHTVLVATGCFIFLTPLGFMTTSYVCIVRTILQIPSASKKYKAFSTCASHLGVVSLFYGTLAMVYLQPLHTYSMKDSVATVMYAVVTPMMNPFIYSLRNKDMHGALGRVLRRLFQRPK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 1D5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SODM_PROFR
Sequence: AVYTLPELPYDYSALEPYISGEIMELHHDKHHKAYVDGANTALDKLAEARDKADFGAINKLEKDLAFNLAGHVNHSVFWKNMAPKGSAPERPTDELGAAIDEFFGSFDNMKAQFTAAATGIQGSGWASLVWDPLGKRINTLQFYDHQNNLPAGSIPLLQLDMWEHAFYLQYKNVKGDYVKSWWNVVNWDDVALRFSEARVA
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.  Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site.
What are the official names of this protein?
Superoxide dismutase [Mn/Fe].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: RL11_RUEST
Sequence: MAKKLVGSMKLQVPAGQANPSPPVGPALGQRGINIMEFCKAFNAKTADMEPGAPCPTVITYYQDKSFTMDIKTPPASYYLKKAAKIKSGANNPSRETAGTVTAAQVKEIAEAKMKDLNANDIEAAMQIILGSARSMGIEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: GATA_LEGPL
Sequence: MEHYSLAQLSKALHNREFSSVELTQHCINKIQSNKDLNAFISLDEDQALKEAQSADLVLKNGEGKPLTGIPMALKDLFCTKRLNTTCASKMLANFQAPYDATIVTKFKQNGAIIIGKTNMDEFAMGSSNENSYFGSVKNPWDRERVPGGSSGGSAAAVAGSLVPFAIGSDTGGSIRQPAAFCGISGIKPTYGLVSRYGMVAFASSLDQAGPFAKSAEDLAMILHCIAGFDSKDSTSADRVIPDYSTEIKKPVDKIRIGLPSCFFQPQVEKGIQDAIHDAVKLFENLGAEIIEIDLKLQPLWVPCYYVIACAEASSNLSRYDGIRFGHRSKSASTLIELITNSRSEGFGNEVKRRILTGTHVLSSGFFDAYYLHAQKVRRLIRDELITILNSVDVILGPTTPTTAFKLGEKIDDPIQNYLADVFTVAANLAGLPAISIPTGFENKLPIGLQLMGKHFSENRLLAIAHHYQQHTNWHLANPNKQG
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: DTD2_HUMAN
Sequence: MAEGSRIPQARALLQQCLHARLQIRPADGDVAAQWVEVQRGLVIYVCFFKGADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCAEARVVVEHGTYGNRQVLKLDTNGPFTHLIEF
What is the function of this protein?
Deacylates mischarged D-aminoacyl-tRNAs (By similarity).  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity).  Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity).  Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity).  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.  In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4. U69) by alanine-tRNA ligase AARS (PubMed:29410408).  Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408).  Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity).
What are the official names of this protein?
D-aminoacyl-tRNA deacylase 2, Animalia-specific tRNA deacylase, ATD, D-tyrosyl-tRNA(Tyr) deacylase 2, L-alanyl-tRNA deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_SHIBS
Sequence: MLRIADKTFDSHLFTGTGKFASSQLMVEAIRASGSQLVTLAMKRVDLRQHNDAILEPLIAAGVTLLPNTSGAKTAEEAIFAAHLAREALGTNWLKLEIHPDARWLLPDPIETLKAAEMLVQQGFVVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLETRAMLEIIIQQATVPVVVDAGIGVPSHAAQALEMGADAVLVNTAIAVADDPVNMAKAFRLAVEAGLLARQSGPGSRSHFAHATSPLTGFLEASA
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_BRUSI
Sequence: MIVGIGSDLIDIRRVEKTLERHGSRFRDRVFTEIEQRKSEGRKQRAASYAKRFAAKEACAKALGTGIAEGVFWRDMGVVNTPSGKPTMHLTGGAAKQLQKLLPAGTNAAIHLTITDDFPLAQAFVIIEALPVLE
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y148_HELPG
Sequence: MGRAFEYRRAAKEKRWDKMSKVFPKLAKAITLAAKDGGSEPDTNAKLRTAILNAKAQNMPKDNIDAAIKRASSKEGNLSEITYEGKANFGVLIIMECMTDNPTRTIANLKSYFNKTQGASIVPNGSLEFMFNRKSVFECLKSEVENLKLSLEDLEFALIDYGLEELEEVGDKVIIRGDYNSFKLLNEGFESLKLPILKASLQRIATTPIELNDEQMELTEKLLDRIEDDDDVVALYTNIE
What are the official names of this protein?
Probable transcriptional regulatory protein HPG27_148.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAUB_RHIL3
Sequence: MLKVDHASVFFAARYGRTVHALDRVSFDIPERGFVVALGASGCGKSTLLNAIAGFLPLSDGRITLDGRAVEQPGADRGVVFQKDSLLPWKSVIDNVALGLKFAGVKRRERQARALELLRLVGLDEFAGAFPYELSGGMRQRVGIARALATNPDILLMDEPFGALDSLTREQMQELLVSIWDKTAKKVFFITHSIEEALFLGTQVLVMSPRPGRVVARFDLDFVRRFAETGDARSIKASPQFAELREEIRAILHSTEDLRSAA
What is the function of this protein?
Part of the ABC transporter complex TauABC involved in taurine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Taurine import ATP-binding protein TauB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NP1L1_RAT
Sequence: MADIDNKEQSELDQDLEDVEEVEEEETGEETKIKARQLTVQMMQNPQILAALQERLDGLVDTPTGYIESLPKVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKPDEEDEVSEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNDLLSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFILEFHFEPNEYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSKTSFFNFFAPPEVPENGDLDDDXEAILAADFEIGHFLRERIIPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ
What is the function of this protein?
Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly.  Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair.  Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity).  Plays a key role in the regulation of embryonic neurogenesis (By similarity).  Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity).  Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity).
What are the official names of this protein?
Nucleosome assembly protein 1-like 1, NAP-1-related protein.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus. Melanosome. Cytoplasm.
Protein: THIM2_STRZP
Sequence: MQALTNPFPIGSSSLIHCMTNEISCEMLANGILALGCKPVMADDPREVLDFTKQSQALFINLGHLSAEKEKAIRMAASYANQSSLPMVVDAVGVTTSSIRKSLVKDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYPGMSFLVTGPKDLIVSENQVAVLENGCTELDWITGTGDLVGALTAVFLSQGKTGFEASCLAVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSLLRRDENWLDTIKGEVYE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 2, 4-methyl-5-beta-hydroxyethylthiazole kinase 2, TH kinase 2, Thz kinase 2.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.