PharMolix/UniProtQA huggingface dataset:
Protein: ADT1_RAT
Sequence: MGDQALSFLKDFLAGGIAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGSSQREFNGLGDCLTKIFKSDGLKGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIAKDEGRKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV
What is the function of this protein?
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).  Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).  In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity).  Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis.  Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity).  Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity).  Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1. 5 kDa, and which contributes to cell death (By similarity).  It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity).  Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity).
What are the official names of this protein?
ADP/ATP translocase 1, ADP,ATP carrier protein 1, Adenine nucleotide translocator 1, ANT 1, Solute carrier family 25 member 4.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A4/ANT1 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (By similarity).
Protein: GPX4_PONPY
Sequence: MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
What is the function of this protein?
Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity).  Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity).  Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity).  Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity).  The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity).  The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity).  May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity).  Required for normal sperm development and male fertility (By similarity).  Essential for maturation and survival of photoreceptor cells (By similarity).  Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity).  Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity).  Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).
What are the official names of this protein?
Phospholipid hydroperoxide glutathione peroxidase, PHGPx, Glutathione peroxidase 4, GPx-4, GSHPx-4.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
[Isoform Mitochondrial]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm.
Protein: REX_STAAB
Sequence: MSDQVKIPRATLKRLPLYYRFVSSLKSKGIDRVNSKAISDALQIDSATIRRDFSYFGELGKKGYGYNIDSLLDFFKSELSESDMVKIAIVGVGNLGKALLTYNFSIHDDMTITEAFDVKEDVIGQKIGNVIVKDNDELITTLKKEEIDVVILTTPERVAQKVADELVQAGVKGILNFTPGRINTPSDVQVHQIDLGIELQSLLFFMKNYSE
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEXB_ENTH1
Sequence: MIVLLLLISYCFAGNGVNVKNQLLLMPYPTTVNAQFGSNDCVEATSNIKMVLSNNCQNDPNCLSFMTFNFNHTITYPLQRQRNLEDFRVSIFAPIDIEEMKGNVVYSANTVNIELTGNNIEEIYPPLKIGIDESYSLDVTKEGIKISATTVYGARLGLETLIQMLRPYQGKYIIKHIPIMIEDKPRLQWRGLMIDVARNSFSRSAFVKIINAMAAIKANVLHIHLSDAQTFMFESKEYPELSKKGAFFQNKVLTQSFIKQLVQYGAKRGVIVYPEIDTPAHTASWNAGYPGVVADIWDYIVSSSMRYGENVLALNPANEKTFSIIDALMKEMGEVFGNDYVHFGGDEVWTGAWSKAKEYPAILEWMNKKGINTLKELEAYFNKYAQEQIIKNGKTPVCWEEVYQKGSADKKTIIQVWNNVNLLKEAATAGYKVILSAGYYLDMQMPLCSDYVADSCTNPNHMWVWTNRDMYRNDPIKELDYATKQNVLGGEACSWDESVDEQNFFDRVFQRFSAVAERFWSSEDITDPESHEVRANYVRCLGLRRNFLKGTGPLYHSYCQLPEDI
What is the function of this protein?
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates (PubMed:15555733).  May contribute to amoebic pathogenicity and may be involved in the destruction of extracellular matrix components (Probable).
What are the official names of this protein?
Beta-hexosaminidase subunit beta, Beta-GlcNAcase subunit beta, Beta-N-acetylhexosaminidase subunit beta, N-acetyl-beta-glucosaminidase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 20 family.
Protein: STB5L_DANRE
Sequence: MKKFRKVLDGLTTSSPVNPGGSPGCGSAAGTPSAAPTPRELEIQETLMSEHFQICKTVRHGFPYQPTALAFDPVQKILAIGSRSGGIRMYPFLSFPHLGRPGVDCHSQHESGAAVLQMQFLINEGALVTACADDTLHLWSLRQRLPAILHSLKFNRERITFCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPKDEGKLLIGFESGTIVMWDLRAKRADFRIYYDEAIHSVSWHHEGRQFMCSHSDGSLSMWNMRNTAKPFQVTFPHGKTQRDGRKESCKPILKVEYKTSRNSSEAFVIFSGGLSYDKAGRRPTLTIMHGKAITVLEMDYPIVDFMVLCETPYLNEVQEPYAVVVLLEKDFVVVDLTQSNFPIFENPYPMDVHESPVTCTAYFADCPPDIIPVLYSIGAKHKKTGYSHKEWPVSGGTWTVGSQTYPEIIITGHADGSIKFWDATAITLQMLYKLKTSKVFEKPKTGDMGRSADLVEEDPYAVQMISWCPQSRIFCVVGISAHVILYRFSKHDANTIITSLELRLQCEMEDVISPSDTENTPCFSDPSGHSPQPQPPSPRSNTPDSVRDSIPCLKVKDRMIRMPPGYQAELVVQLLWVDGEPPQQITCLDLNSAYGLLALGNCNGLAVVDYLQKTILLCMSTLELYGSADPFQRLTRSPRKNRQSTSGLTELSDNQVSLDLERSKSPTSDHVNGHCTSPTSQPCPSGRARVPGGPEGPRLARRGPGRPPFRKAQSAACMEVSLPVSSLTEENSFSRSRSSSVSSIDRETKEAVTTLQFAESYGRKSDSLPTPCLWVGTSLGLVLIIPMSIPTDEQERQEDPVTVAPTGTVLMLKGSVLRFGFLDCGGALINSPYEVWRDQHAPDDPDRPRKRKLVNFSPSSSQEACGDGHLAVVCSERQAKVFYMPSQACLYVHNITESSFVLRADVVSVSNSVCLACFCANGHIMILSLPSLRPLLDVSYLPLTDMRIARTFCFTNGGQALYLCSPTEIQRITYSQEMCETLGELFTPIETPEAQNRGFLKGFFGGNAQTFDREELFGEASAGKASRSLAQHIPGQGGIEGMKAAAGGVVGDLARARIALDERGQRLGELEERTALMMTSAETFSKHAHELMLKCKDKKWYQF
What is the function of this protein?
May play a role in vesicle trafficking and exocytosis.
What are the official names of this protein?
Syntaxin-binding protein 5-like.
What is the protein family that this protein belongs to?
Belongs to the WD repeat L(2)GL family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane; Peripheral membrane protein. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane.
Protein: RLMM_PSEE4
Sequence: MNTLFMHCRPGFEGEVCAEISEHAALLGVAGYAKGKPQSACAEFVCTEPDGAQRLMHELRFAQLIFPRQWARGAFVELPETDRISVLLEHLADLPVCGSLWLEVLDSNEGKELSTFCRKFEVPLRKALEKAGRLVDDARRPRLLLTFISGRRVFLGLAEADNSALWPMGIPRLKFPREAPSRSTLKLEEAWHQFIPREQWEQRLNDDMTGVDLGASPGGWTYQLVKRGMLVTAIDNGPMAESLMDTGLVTHLMADGFTWKPKHTVDWMVCDIVEKPARTASLIETWLGEGLCREAVVNLKLPMKQRHAEVRKLLDRMEAGFKERKVKVSIACKQLYHDREEVTCHLRRLDLKPH
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_PSESM
Sequence: MQNQQIRIRLKAFDHRLIDQSTQEIVETAKRTGAQVRGPIPLPTRKERFTVLVSPHVNKDARDQYEIRTHKRVLDIVQPTEKTVDALMKLDLAAGVEVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RARD_SALTY
Sequence: MDAKQTRQGVLLALAAYFIWGIAPAYFKLIYYVPADEILTHRVIWSFFFMVALLSVSRQWRQVKRLLKTPKKIFLLALSAVLVGGNWLLFIWAVNNHHMLEASLGYFINPLVNILLGMIFLGERFRRMQWLAVILAVCGVLVQLWTFGSLPIIALGLAFSFAFYGLVRKKIAVEAQTGMLVETLWLLPVAAIYLFGIADSPTSHMGQNALSLNLLLMAAGVVTTIPLLCFTGAATRLRLSTLGFFQYIGPTLMFLLAVTFYGEVPGADKMVTFAFIWVALAIFVMDAIYTQRKK
What are the official names of this protein?
Protein RarD.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AMZA_SULIN
Sequence: MTEMKILIVTLTYIEKSIIDEIVNNLSSYGLEVDILFDSRKYLPISAFNWERLQYDAEKVLSFLKSKYDFNYDSIIFLADSDGYIDGYNFVFGLTIDNFAIIFLNRLREEFYNRKPDLELFMKRVVKEVTHEAGHILGLGHCNTIGCVMNFSNTVEDVDKKQARFCKNCIYKIENLSKYLQRK
What is the function of this protein?
Probable zinc metalloprotease whose natural substrate is unknown.
What are the official names of this protein?
Archaemetzincin.
What is the protein family that this protein belongs to?
Belongs to the peptidase M54 family.
Protein: GNAI1_BOVIN
Sequence: MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades.  The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state.  Signaling by an activated GPCR promotes GDP release and GTP binding.  The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal.  Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity).  Signaling is mediated via effector proteins, such as adenylate cyclase.  Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity).  The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane.  Required for normal cytokinesis during mitosis (By similarity).  Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-1, Adenylate cyclase-inhibiting G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex. Membrane; Lipid-anchor. Note=Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane.
Protein: MAZG_THEMA
Sequence: MKEAGILFEELVSIMEKLRSPEGCEWDRKQTHESLKPYLIEECYELIEAIDEKNDDMMKEELGDVLLQVVFHAQIARERGAFTIEDVIRTLNEKLIRRHPHVFGDSPGYSYKQWEDIKAQEKGKKKSSRIGEINPLVPALSMARRIQENASQVGFDWKDPEGVYEKIEEELKELKEAKDPRELEEEFGDLLFSIVNLSRFLNVDPESALRKATRKFVERFKKMEELIEKDGLVLEELPIEKLDEYWEKAKGGDET
What is the function of this protein?
Catalyzes the hydrolysis of all eight canonical ribonucleoside triphosphates (NTP) and deoxyribonucleoside triphosphates (dNTP) to their corresponding nucleoside monophosphates ((d)NMP) and PPi and subsequently hydrolyzes the resultant PPi to Pi.  The NTPase activity with deoxyribonucleoside triphosphates as substrate is higher than corresponding ribonucleoside triphosphates.  dGTP is the best substrate among the deoxyribonucleoside triphosphates, and GTP is the best among the ribonucleoside triphosphates.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphohydrolase/pyrophosphatase MazG, NTP-PPase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside triphosphate pyrophosphohydrolase family.
Protein: SYR_CITK8
Sequence: MNIQALLSEKVSQAMIVAGAPANCEPQVRQSAKVQFGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLNGIASKVEIAGPGFINIFLDPAFLAEHVQQALASERLGVAKPAKQTVVIDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFLGHHVIRANHVGDWGTQFGMLIAWLEKQQQENAGEMALADLEGFYRDAKKHYDEDEAFAERARNYVVKLQGGDPYFLDMWRKLVDITMTQNQITYNRLNVTLTRDDVMGESLYNPMLPGIVADLKAQGLAVESEGATVVFLDEYKNKEGEPMGVIIQKKDGGYLYTTTDIACAKYRYETLHADRVLYYIDSRQHQHLMQAWTIVRKAGYVPDSVPLEHHMFGMMLGKDGKPFKTRAGGTVKLADLLDEALERARRLVAEKNPDMPADELEKLANAVGIGAVKYADLSKNRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVLSVFRKAEIDESALSSAPVVIREDREAQLAARLLQFEETLTVVAREGTPHVMCAYLYDIAGLFSGFYEHCPILSAENEEVRNSRLKLAQLTAKTLKLGLDTLGIETVERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBA2_SCHPO
Sequence: MREIISIHVGQAGTQIGNACWELYCLEHGIQPNGYMNPETASQNSDGGFSTFFSETGQGKYVPRSIYVDLEPNVIDQVRTGPYRDLFHPEQLITGKEDASNNYARGHYTVGKELVDEVTDKIRRIADNCSGLQGFLVFHSFGGGTGSGFGALLLERLAMEYTKKSKLQFSVYPAPQVSTSVVEPYNSVLTTHATLDLADCTFMVDNESCYDICRRNLDIERPSYENLNRLIAQVVSSITASLRFEGSLNVDLAEFQTNLVPYPRIHFPLVTYAPIVSAAKAFHESNSVQEITNQCFEPYNQMVKCDPRAGRYMATCLLYRGDVIPRDVQAAVTTIKAKRTIQFVDWCPTGFKIGICDRPPQHIEGSEIAKVDRAVCMLSNTTSIAEAWSRLDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVGQDSMEVDYMEEEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-2 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PFDB_SULIA
Sequence: MAEKLPPEVQAQLAKFQQLKDQLDRLLLEKSTIENELREINKVLEELSVLNADATIYKIVGNLLVKSDKTSVEKELNDRKELLELRSRTYQKQESILRKQLEDLQAKINEMLSKYYPQGGQTGIKA
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCDA_METTH
Sequence: MFPDIEVNDKGHLLIGGADAVELADEYGTPLYVIDEMRIRENYRRLYRAFSGEYSRFQVFYACKANTNLAVMRILEEEGSGIDAVSPGEIYTALMAGFDPDRILYTGNNVRDDELQFALDSGVRINVDSRSQLLRLSEIAPEGLRISFRVNPLVGAGHHEHCITGGEMSKFGVMEREAPEVYRMAMDLGFEPVGIHAHIGSGILDPEPFMLAVETLMDIAGRVHEATGVEFEFIDFGGGLGIPYTPEEEPLDIDEFASKITGLFKDKLSEYGLGRPMMCLEPGRYIVGDASYLLTRVNTIKESYRKFAGVDAGFNTLLRPAMYGSYHHILVAERPLDEPSEKMDVAGNVCESGDLFARDRQLPEINEGDVLAIMNAGAYSFSMSSQYNSRPRPAEVLVREGKVDVVRERETFSDLLRGQNVPARLLKR
What is the function of this protein?
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
What are the official names of this protein?
Diaminopimelate decarboxylase, DAP decarboxylase, DAPDC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
Protein: MALD_STRR6
Sequence: MNNSIKLKRRLTQSLTYLYLIGLSIVIIYPLLITIMSAFKAGNVSAFKLDTNIDLNFDNFKGLFTETLYGTWYLNTLIIALITMAVQTSIIVLAGYAYSRYNFLARKQSLVFFLIIQMVPTMAALTAFFVMALMLNALNHNWFLIFLYVGGGIPMNAWLMKGYFDTVPMSLDESAKLDGAGHFRRFWQIVLPLVRPMVAVQALWAFMGPFGDYILSSFLLREKEYFTVAVGLQTFVNNAKNLKIAYFSAGAILIALPICILFFFLQKNFVSGLTSGGDKG
What is the function of this protein?
Part of the binding-protein-dependent transport system for maltodextrin; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Maltodextrin transport system permease protein MalD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUF2_ENCCU
Sequence: MQKRNVYAVPDLPVKEIMQYFSEMEINIKASDILKPTPQSTQRIYEVLLEVYCGVKTSDLLPRINSGESIEAFEESLSCILLQKRMSGFLKRIGIDNFGLRDLVPDSRRLIGILSVVVNFSMFRDNKRHVYERVCQMNDEKLLLKNEIDEKVHNAKKELERCERDARKSIEEAKGVEEEISLLESELKDFYRHQRALVQETERSKTERNEYSDKLSSLKLMVLNLNQEITCLKTQIVSDPTKLMELLDEMRCLIAKESEIMKGLEVKRVGLKEKIEFMQVLKEDTMKAITLAISNREADKTIDKTNREISELEVQMKNLDSGINALKIRLNHVSRQISHIESKIFNLQDNDKRCSEEISAKLEKLKSNYGVVSDERNSIRGKIEENVRLTKSIEYELVKRRNEHANDITAIQSALCRLKDDVFNYFAEAKGIIDKTMSD
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
What are the official names of this protein?
Probable kinetochore protein NUF2.
What is the protein family that this protein belongs to?
Belongs to the NUF2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Protein: NORV_AERHH
Sequence: MSIHVKNNIHWVGQRDWEVRDFHGTEYKTHKGTSYNSYLIREGKNVLIDTVDHKFSREFVQNLAAEIDLATIDYVVINHAEEDHAGALTELMARIPGTPIYCTHNAIDSITGHHHHPEWNFHPVKTGDSLDIGNGKQLVFIETPMLHWPDSMMTYMTEDAVLFSNDAFGQHYCDEHLFNDEVDQTELMEQCQRYYANILTPFSPLVTAKIKEVLGFNLPVSMVATSHGIVWREDPTQIILKYLEWADHYQEDRITLFYDSMSNNTRMMADAIAQGIHEVDPGVAVKIYNVARHDKNEILTQVFRSKGILVGSSTMNNVMMPKVAGMLEEITGLRFRNKRASAFGSYGWTGGAVDRIQTRLMDAGFDISISLKAKWRPDGSALAECREHGRQLARQWALHPLDAPRPLATTQATPAPEMPAAVTAAPKATAAAAEWDDDQAMLCTVCQWVYDPAQGEPDQLVAPGTPWAQVPDSFLCPGCGIGKEVFEPCAVEACV
What is the function of this protein?
Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes.  Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified.  NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center.  Also able to function as an aerobic oxygen reductase.
What are the official names of this protein?
Anaerobic nitric oxide reductase flavorubredoxin, FlRd, FlavoRb.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCPR_MOUSE
Sequence: MGDSHEDTSATVPEAVAEEVSLFSTTDIVLFSLIVGVLTYWFIFKKKKEEIPEFSKIQTTAPPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVVHEDMDTAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSTLVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRTKEPAGENGRRALVPMFVRKSQFRLPFKPTTPVIMVGPGTGVAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDKEHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS
What is the function of this protein?
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes.  It can also provide electron transfer to heme oxygenase and cytochrome B5.
What are the official names of this protein?
NADPH--cytochrome P450 reductase, CPR, P450R.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: ETV1_HUMAN
Sequence: MDGFYDQQVPYMVTNSQRGRNCNEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSACSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYVY
What is the function of this protein?
Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741).  Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity).
What are the official names of this protein?
ETS translocation variant 1, Ets-related protein 81.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UPP_NEIG1
Sequence: MNVNVINHPLVRHKLTLMREADCSTYKFRTLTTELARLMAYEASRDFEIEKYLIDGWCGQIEGDRIKGKTLTVVPILRAGLGMLDGVLDLIPTAKISVVGLQRDEETLKPISYFEKFVDSMDERPALIIDPMLATGGSMVATIDLLKEKGCRNIKALVLVAAPEGVKAVNDAHPDVTIYTAALDSRLNENGYIIPGLGDAGDKIFGTR
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.