PharMolix/UniProtQA huggingface dataset:
Protein: OSTCN_MACMU
Sequence: MRALTLLALLALATLCITGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPAPYPDPLEPKREVCELNPDCDELADHIGFQEAYRRFYGPV
What is the function of this protein?
Constitutes 1-2% of the total bone protein.  It binds strongly to apatite and calcium (By similarity).
What are the official names of this protein?
Osteocalcin, Bone Gla protein, BGP, Gamma-carboxyglutamic acid-containing protein.
What is the protein family that this protein belongs to?
Belongs to the osteocalcin/matrix Gla protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: UPP_SHIB3
Sequence: MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: TYW4_EMENI
Sequence: MCPPEQPAKAMAPSKSNQAAKSAVPTKEEKSADLVMATNNSSIVSKRSVEMLYYPEPHFFCHFVKKPQRRAPLINRGYWLRMHAMEESVRRFMRESPDKPKFVLNLGCGFDPLPFILLSADRSLCSQTTFVDIDYEKLMLNKKAALREAGALTQILEDVEFGPDESAVQIRSGQYVAVGCDLKNLDKLDRVLRAEVLPAECAVLFLAEVSLTYMDVKSANAVVSWASRLSNDAQFCILEQYFPDGPSHPFAATMMEHFGKLGAPLHSIHEFPSLSDQERRFTEAGWTHAHARSLWDLWSDDEFVPAVLRTSLDSIESFDEWEEFALFASHYFLLHASTRPGTKGSKSAAATADVGPSRQAVTRSNEFRLIPNTSLPTGQRRFGALVPGGEAVIGIHSGWGRQTRVADTDVYKTSKDNIDSHARFPSSNDISARLCHTITAFSDDGDCLLVGGRTSPASALQDTWVRKNNVWQAGSSLPLARFRHCATRVTLGSDRSSGSVLIYGGKTSDGTTLDTWLLWNDNGEGWSSVTVRTMNDAPAPKARFGACLASIDSTNGLLFGGIGPDGTILEDFWTWKLYEEADGSLCMELTDQTGSLRNIALGFDILPRFGATVSSTAQGLVVSGGIIPRRVVPFDGEILLLDSATLLDCIKNGLPLTTPILSTIGLDAGFTGPRPLLVGHVSHAISTDQVLLLGGGAVCFSFGTFWTRGTWMLCPVGERAVNDWALVCENVEKPTKAKAAAQIPAKTKKQKASKKYKPEKYKSTTKVTPIRRVTVESADEFQQILEDAQPVIIESADIGPCTELWTKEYLVNTVGSDRKVIVHAAETETMSFRTKNFKYESKTFGTFMDEVHAGGRQYLRSISEKQPAKLPANLAADFPSLSSDFRLPEALKTVVENAHSSPLRISGPVTLWLHYDVMANVLCQIQGEKRLILYPPSDVPHLDVPAGASSSNINVFQNRADGAIALIPHTSPHEARLKRGDILFIPPLWLHTAAPTGKVSVAVNVFFRNLSQGYALGRDVYGNRDVQAYEKGRKDLEKLVKSFSGLPPDMARFYLLRLADELQETAEQ
What is the function of this protein?
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.  May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity).
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 4, tRNA-yW synthesizing protein 4, Leucine carboxyl methyltransferase 2, tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LCMT family.
Protein: COR47_ARATH
Sequence: MAEEYKNNVPEHETPTVATEESPATTTEVTDRGLFDFLGKKEEEVKPQETTTLESEFDHKAQISEPELAAEHEEVKENKITLLEELQEKTEEDEENKPSVIEKLHRSNSSSSSSSDEEGEEKKEKKKKIVEGEEDKKGLVEKIKEKLPGHHDKTAEDDVPVSTTIPVPVSESVVEHDHPEEEKKGLVEKIKEKLPGHHDEKAEDSPAVTSTPLVVTEHPVEPTTELPVEHPEEKKGILEKIKEKLPGYHAKTTEEEVKKEKESDD
What are the official names of this protein?
Dehydrin COR47, Cold-induced COR47 protein.
What is the protein family that this protein belongs to?
Belongs to the plant dehydrin family.
Protein: SYFB_MYCPU
Sequence: MLFSINKLRDLANLDKQITNDQIIDAINKIGFEVESVKNFLNVSKIKFGLIKKVYKNPNASNLNVCEIEFEDKMRIIQTTAQNVEQNKYIVAFVENSTFGKIKIEAKEIKGTFSQGMLCSLEELGFDKSLIRDEFQDKIFLLDKADLKQDPIDFFDLDDQIVDVSILSNRSDANGYFIMALELSAFFETKTNFEIKNEIFKIHPNLKVDETNTLDFVLIEPQKELKKISLKDQILIMKSNIKTFNDLVDLTNLNLIMNAMPTHVYDKDKISNEISVKKVSQEVSILGNKKISLDNNLVVCSKEKPISIAGVIGIADFGSDQNTKNFVFEIGRFKTLDIQKSIKSVKLDTQSSKLSSKKISSGTFKMALNFLTSYFDSQVLVSKNLKDKKESFNFVWEDLNKFLNTDVKKMPHFNRVLKSLNILGFEFKDNKVYLPTYRHDIEHVQDILEEFLRFYGYENLVFEAPNIKNFETKNYEEYLNFIPYLNYSETRTYSLVSKDKNIFNPFNFKENINLETFHSKEREQIRNSMILSMEEVLQYNLKRKVENVNIFEIGIINNSQRSLALLSNQKSFNRFKEDVESILKDKLYSFEKGGFDFSHPLESIIIKDNDQLIGYIIRANAKDFEEDFVYAEILIDKLRNKKIENKSLNYLPLKTLDINFEVPSENGLFEVYKTLEKNEKIYSYKLIDHYQKNQISIYTIRIWAFEENIEELKTLFNL
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FM1AA_MOUSE
Sequence: MDLHTAVYNAAHDGKLPLLQKLLAGRGREELEELLGEVAGGGTPLLIAARRGHLDVVEYLVDHCGASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLDVVRYLVGEHKADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCHARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGHEQLSGTELPGEGSSQVAGNHCSTPEEAEPYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGGYLPKPEPQQLVLAYDYSREVTTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDRSAKGNLGMQLGFADLMGVLSKGVREVERALQLPKEPGDSAQFTKAIAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKETTNVGRYRVGVFPSLQVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMDALIEAGAHMDATNAFKKTAYELLDSKLLAKSTVQPFNYVTLQCLAARALDRNKVPYKGFIPEELEAFIQLH
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity).  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity).  The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity).  Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (PubMed:18270204, PubMed:26439841).  Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (PubMed:27315781).
What are the official names of this protein?
Protein fem-1 homolog A-A, FEM1a-A, FEM1-alpha-A, Prostaglandin E receptor 4-associated protein.
What is the protein family that this protein belongs to?
Belongs to the fem-1 family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: CH10_LACGA
Sequence: MLQPIGDRVIVKVKDEEEEKVGGIVLASNAKEKPQMGEIIAVGNGKRNANGDLIPMSVAKGETVFFDKYSGTNLKYEGEKYLVLRESDLLAVVK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATF6A_HUMAN
Sequence: MGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAANETYENNFDNLDFDLDLMPWESDIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKTENGLTPKKKIQVNSKPSIQPKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTVVQLQAPGVLPSAQPVLAVAGGVTQLPNHVVNVVPAPSANSPVNGKLSVTKPVLQSTMRNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYGPMSMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATHVVSTIPESLQ
What is the function of this protein?
Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11163209, PubMed:11158310, PubMed:11779464).  Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464).  Binding to ERSE requires binding of NF-Y to ERSE.  Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464).  May play a role in foveal development and cone function in the retina (PubMed:26029869).
What are the official names of this protein?
Cyclic AMP-dependent transcription factor ATF-6 alpha, cAMP-dependent transcription factor ATF-6 alpha, Activating transcription factor 6 alpha, ATF6-alpha.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Translocates from the endoplasmic reticulum to the Golgi, where it is processed. SUBCELLULAR LOCATION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus. Note=Under ER stress the cleaved N- terminal cytoplasmic domain translocates into the nucleus (PubMed:10564271, PubMed:12782636). THBS4 promotes its nuclear shuttling (By similarity).
Protein: GATA_PSEF5
Sequence: MHHMTLAEIARGLADKKFSSVELTQTLLARIAQLDPQINSFISLTQDLALSQAKAADERRANGESGALLGAPIAHKDLFCTQGIRTSCGSKMLDNFKAPYDATVVAKLAAAGAVTLGKTNMDEFAMGSANESSWYGAVKNPWNLEHVPGGSSGGSAAAVAARLLPAATATDTGGSIRQPAAFTNLTGLKPTYGRVSRWGMIAYASSLDQGGPLARTAEDCAILLQGMAGFDPNDSTSIDEPVPDYSAGLTGSLQGLRIGVPKEYFSAGLDPRIAELIHNSIKELEKLGAVIKEISLPNMQHAIPAYYVIAPAEASSNLSRFDGVRFGYRCENPENLEDLYKRSRGEGFGSEVQRRIMVGAYALSAGYYDAYYLKAQKIRRLVKNDFMTAFNEVDIILGPTTPNPAWKLGAKSSDPVAAYLEDVYTITANLAGLPGLSMPAGFVDGLPVGVQLLAPYFQEGRLLNVAHQYQLNTDWHTRTPTGF
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: CTRC_BOVIN
Sequence: MLGITVFTTFLAYASSCGAPIFQPNLSARVVGGEDAIPHSWPWQISLQYLRDNTWRHTCGGTLITPNHVLTAAHCISNTLTYRVALGKNNLEVEDEAGSLYVGVDTIFVHEKWNSFLVRNDIALIKLAETVELSDTIQVACLPEEGSLLPQDYPCFVTGWGRLYTNGPIAAELQQGLQPVVDYATCSQRDWWGTTVKETMVCAGGDGVISACNGDSGGPLNCQAENGNWDVRGIVSFGSGLSCNTFKKPTVFTRVSAYIDWINQKLQL
What is the function of this protein?
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors (By similarity).  Has chymotrypsin-type protease activity and hypocalcemic activity (By similarity).
What are the official names of this protein?
Chymotrypsin-C, bPTLP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Elastase subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: RL28_BORPD
Sequence: MARVCQVTGKGPMTGNNVSHANNKTKRRFLPNLQSRRFWVESENRWVRLRVSAKAIRIIDKNGIDAVLADLRARGELA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: ALR_RICAE
Sequence: MSLCTVEINLSTIKNNYLLLQDICKTSLVGAAVKANGYGLGAVQISKALIEENCRHFFVASSEEGVNLRNALGLDVNILVLNGVFEHDALELIEYNLTPVLNNLKQIEIWQKFSNLKNRLLSCYLHFNTGINRLGLSSDEIEQLINDRDLLKGLDLQYIISHLAISEEIDNPYNLEQLNRFKAYLQYFPNVKASLANSGGIFLGQDYHFDLARPGAALYGLNPLTKNPVTLKAPIIHLQNLTLDSHIGYNMTFTTKRDSVIATLPLGYADGFSRNFSNQGEVFINSRSVPIVGRVSMDLINIDVTDLPPSEIFLGQEAEIIGNYCTPDKIASIIGTIGYEVLTNLGSRYKRKYIG
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: VME1_BC279
Sequence: MTDNGTITVEELKQLLEQWNLVIGFIFLAWIMLLQFAYSNRNRFLYIIKLVFLWLLWPVTLACFVLAAVYRINWVTGGIAIAMACIVGLMWLSYFVASFRLFARTRSMWSFNPETNILLNVPLRGTILTRPLLESELVIGAVIIRGHLRMAGHSLGRCDIKDLPKEITVATSRTLSYYKLGASQRVGNDSGFAAYNRYRIGNYKLNTDHSGSNDNIALLVQ
What is the function of this protein?
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
What are the official names of this protein?
Membrane protein, M protein, E1 glycoprotein, Matrix glycoprotein, Membrane glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses M protein family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer.
Protein: PHNC2_PSESM
Sequence: MNAAIHVQGLNKTFSNKSALLDLALSIQPGEMVALIGASGSGKSTLLRHLAGLACCDRSNGGQVQVLGREVQSSGRLNGQVRRLRADIGYIFQQFNLVNRLSVMDNVLIGCLGRMPRWRGSLGLFNREEKQRAMVALDRVGLADLAAQRASTLSGGQQQRVAIARALTQRAEVILADEPIASLDPESARRVMEILADINRQDGKTVVVTLHQVDYAVRYCPRAVALKGGRIHYDGPAQDLSKPFLNDLYGADEDASLMITERSRRVRQKPRLVLAKV
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AROE_BRUSU
Sequence: MDDKSMARGRKAFVTGFPIKHSRSPLIHGFWLKELGIDGSYEAVEVKPEDFSSFAASLAANGFAGGNVTIPHKEAAYAAAESLDEAACAIGAVNTLWLENGRLCGGNTDAYGFAANLDASAPGWDKADRALVLGAGGASRAVVHALLSRGVCHVSVVNRTLSRAEELAAHFGARVYAHGWDEAQALVSNAGLIVNTTALGMSGHGEGQDFPIDLTCAPKEAVATNIVYVPLRTAFLNKAEKAGLKTVDGLGMLLHQAVPGFERWFGQRPQVTQALREHILADMAKAGAL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: SYA_ALKCK
Sequence: MQRLSSASVRQMFIDFFKEKGHSVEPSASLVPFEDPSLLWINSGVATLKKYFDGRVIPENPRIVNAQKSIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKEQAIEWAWEFLTDKKWIGFPQERLSVTVHPEDEEAYRYWHQHIGLPEERIIRLEGNFWDIGEGPSGPNSEIFYDRGPEYGDDPNDPELYPGGENERYLEIWNLVFSQFNHNADGTYTPLPKKNIDTGMGLERMVSVIQDTPTNFETDLFMPIIEATEALASTTYKEADTAFKVIADHIRTVAFAVGDGALPSNEGRGYVLRRLLRRAVRFAKSIGIDRPFMYELVPVVGAIMKDFYPEVADKQDFIARVIRTEEERFHETLNEGLAILSDIIEKAKATNKETIAGEDAFRLYDTYGFPIDLTEEYVHDEGLTVDRAGFDQEMEQQRQRARAARQESASMSVQEDVFGEVKTPSVFVGYEHTETDAVITTLVRGKEKVEQAVQGDVIQFFLDETPFYAESGGQVADRGMIVTDTGQAVVKDVKKAPNGQHLHTAEVTIGEISTGQQASARIEVRERLDIVKNHTATHLLHQALKDVLGEHVNQAGSLVSSERLRFDFSHFGQVTPNELQQIEEIVNEKVWQALPVDISIQRLEEAKAAGAMALFGEKYGSEVRVVRVGDYSLELCGGCHVRNTAEIGLFKITSESGIGAGVRRIEAVTSKGAYQFLSEQTAILKDAAERLKAKRLSDVPQRIESLQEELRKAQRENESLTAKLGQAEAGNLNDQVKEIGGVAVIAAQVDAKDTEALRSMVDTLKQAHEKAVIVLAAKTGNKLAFVAGVTKPAIAEGFHAGKLIKEVAARTGGGGGGRPDMAQAGGKDPAKLDEALAYVHEYVKSIS
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL2_HPV34
Sequence: MRRKRDTHIRRKRASATQLYKTCKQSGTCPPDIIPKVEGNTLADQILKYGSIGVFFGGLGIGSGSGTGGRTGYVPLPTTTPSRPVEIPLQPTRPPVITSVGASDSSIVSLVEESSFIEAGVPGPTSIVPSSSGFNVTTSVDSTPAIIDVATISDTTQVSVSTFNNPTFTDPSVLQPPPPLEASGRLLFSNDTVTTHSYENIPLDTFVVTTDNNSIVSSTPIPGRHPPARLGLYGRAIQQVKVVDPAFVTTPTRLVTYDNPAFEGLQDTTLEFQHSDLHNAPDSDFLDIVKLHRPALTARKTGIRVSRLGQRATMFTRSGKRIGGRVHFYHDLSPIPTENIELQPLLPSASATVTDANGINDGLYDVLLDNNVDITEVETPTGTNTQSVFASEISTTTANTTIPLNAGLDTHPGPDIALPVPTAETIFTPTVPVQPSGPIYIYGSDFILHPSLYVIPRKRKRLSYFFADVATY
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: LDH1_STAA2
Sequence: MNKFKGNKVVLIGNGAVGSSYAFSLVNQSIVDELVIIDLDTEKVRGDVMDLKHATPYSPTTVRVKAGEYSDCHDADLVVICAGAAQKPGETRLDLVSKNLKIFKSIVGEVMASKFDGIFLVATNPVDILAYATWKFSGLPKERVIGSGTILDSARFRLLLSEAFDVAPRSVDAQIIGEHGDTELPVWSHANIAGQPLKTLLEQRPEGKAQIEQIFVQTRDAAYDIIQAKGATYYGVAMGLARITEAIFRNEDAVLTVSALLEGEYDEEDVYIGVPAVINRNGIRNVVEIPLNDEEQSKFAHSAKTLKDIMAEAEELK
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate (Potential).  Appears to be the primary factor that allows S. aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells (By similarity).
What are the official names of this protein?
L-lactate dehydrogenase 1, L-LDH 1.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSQ_SHEON
Sequence: MSWSDKRRHWRARKSQVNWYLWSGIGFLSLVIGSFVFGGYLLHKFLNDASTLPIEAVAIKGERTYTTDKDIQIALQDLMQRSFFSADITLVQQALEALPWVYRASVRREWPAKLRVYLQEQQPAAHWNGTAWLNVHGEVFEAPSHPELEHLPHLSGPDDMGTEVLTAYAQVNSLLKINGFTLASLNLTPRHAWHATLGNGIVLDLGREDKMARIQRFITVYPLLAKQDKPIARVDLRYDTGLAVGWGDAQTREPIINDEKPR
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.  May control correct divisome assembly.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: CSPD_BACSU
Sequence: MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEGQEVSFEIVEGNRGPQASNVVKL
What are the official names of this protein?
Cold shock protein CspD.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNUC_YERPE
Sequence: MMPILVTLNKISVTFGSRRVLNDISLSLRPGKILTLLGPNGAGKSTLVRVVLGLIPPSSGSLVREPGLRIGYVPQKLHLDATLPLTVSRFMRLKPGVKKADILPALTRVQAAHLLDQPMQKLSGGENQRVLLARALLNRPQLLVLDEPTQGVDVNGQLALYDLIEQLRKELGCAVLMVSHDLHLVMAKTDEVLCLNQHICCSGAPEVVSTHPEFIAMFGNRGAEQLAVYRHNHNHRHDLHGKIILKNSGSRGA
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MEG11_HUMAN
Sequence: MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSGACGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHMGSPYTDVPSLSTSNKNIYEVEPTVSVVQEGCGHNSSYIQNAYDLPRNSHIPGHYDLLPVRQSPANGPSQDKQS
What is the function of this protein?
May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion.  Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).
What are the official names of this protein?
Multiple epidermal growth factor-like domains protein 11, Multiple EGF-like domains protein 11.
What is the protein family that this protein belongs to?
Belongs to the MEGF family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10.
Protein: CARA_YERPE
Sequence: MIKSALLVLEDGTQFHGRAIGAEGTAVGEVVFNTSMTGYQEILTDPSYSRQIVTLTYPHIGNVGTNASDEESSAVHAQGLVIRDLPLIASNYRNEEGLSEYLKRHNIVAIADIDTRKLTRLLREKGAQNGCIIVGELSDAALALEKAKAFPGLKGMDLAKEVTTKEMYQWLQGSWTLEGDLPAAKQPEDLPFHVVAYDYGVKRNILRMLVDRGCRLTVVPAQTPAEDVLKLNPDGIFLSNGPGDPEPCDYAITAIKRFLETDIPVFGICLGHQLLALASGAKTVKMKFGHHGGNHPVKDLDASCVMITAQNHGFAVDETSLPSNLRTTHVSLFDGSLQGLHRTDKAAFSFQGHPEASPGPHDAAPLFDHFIELIEAYRASSVSLNCSNSHK
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.