PharMolix/UniProtQA huggingface dataset:
Protein: EPAE_ASPNC
Sequence: MESLAHLPGIFLPLAGCVLALSLTTIVYRTVTNPLSHIPGPQISKWSSLIEQYYWFAGTKVEYVDYLHRKYGPIVRVTPTEVDICDLPAVREIHRVRGGYLKSEWYKSLTPPGVTSLLTLIEPAQYSEWRRLLAGPLSDTSLGKVEPMVTNHVHATIDRIASDLQSQGVSDLYKWWTYMATDVVSELSFGEPIGLLARPKETAWVMDYLDKVGIMHAWRTTFPFVFVLGRFMPVHPFKHAIQAIGLLGKWARQSIQQYRQHIQEQPESPKPTLFTKLFKTGKFDDFQLTYLAGSYITAGSHTTAVTLLYLIYAICSDNEVRQKLLAEIRTLPENFRHDELRHLPYLNQVITETLRKYAVVSSALPRVVPAGGATLAGYYLPGGTTVSTQAYTLHRNEAIFPNPEKFDPSRWESPTQDMKDAYMPFGGASRMCIGNSLALMEIRLTTTLFLRRFPEVHMSRQNGMRDEDLAQEQYLIMAPRGQRLLVEA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of nigerpyrone and its derivatives carbonarone A and pestalamide A (PubMed:30384904).  The biosynthesis pathway begins with the polyketide assembly by epaA to form phenylacetyl triketide precursor from successive condensation of two malonyl-CoA, presumably with one phenylacetyl-CoA starter unit produced by the phenylacetyl-CoA ligase epaB (PubMed:30384904).  For the nigerpyrone biosynthesis, the reactive polyketide chain is released as an aldehyde through the R-domain.  A nonenzymatic cyclization and dehydration may create nigerpyrone (PubMed:30384904).  For the biosynthesis of carbonarone A and pestalamide A, an extra methyl group is added through the C-methyltransferase domain.  Several further steps involving the dehydrogenase orf1, the cytochrome P450 monooxygenase orf2 and the FAD-dependent monooxygenase orf3 are required to form a carbonarone A precursor which is converted to carbonarone A via cyclization (PubMed:30384904).  The O-acetyltransferase epaC could catalyze the transfer of 2-methylsuccinyl-CoA, a common intermediate in the ethylmalonyl-CoA pathway, to generate the final product pestalamide A (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase orf2, Pestalamide A biosynthesis cluster protein orf2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: XPP1_HUMAN
Sequence: MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSETIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQKQGRQEALEWLIRETQPISKQH
What is the function of this protein?
Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11106490, PubMed:35165443, PubMed:18515364).  Contributes to the degradation of bradykinin (PubMed:11106490).
What are the official names of this protein?
Xaa-Pro aminopeptidase 1, Aminoacylproline aminopeptidase, Cytosolic aminopeptidase P, Soluble aminopeptidase P, sAmp, X-Pro aminopeptidase 1, X-prolyl aminopeptidase 1, soluble.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLYX_KLEP7
Sequence: MHDSTLETRLAELESRLAFQEITIEDLNKTVTAHEIEMAKMREHMRLMIEKLKATQPSHIASQAEETPPPHY
What are the official names of this protein?
Protein SlyX.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: SURA_ECO57
Sequence: MKNWKTLLLGIAMIANTSFAAPQVVDKVAAVVNNGVVLESDVDGLMQSVKLNAAQARQQLPDDATLRHQIMERLIMDQIILQMGQKMGVKISDEQLDQAIANIAKQNNMTLDQMRSRLAYDGLNYNTYRNQIRKEMIISEVRNNEVRRRITILPQEVESLAQQVGNQNDASTELNLSHILIPLPENPTSDQVNEAESQARAIVDQARNGADFGKLAIAHSADQQALNGGQMGWGRIQELPGIFAQALSTAKKGDIVGPIRSGVGFHILKVNDLRGESKNISVTEVHARHILLKPSPIMTDEQARVKLEQIAADIKSGKTTFAAAAKEFSQDPGSANQGGDLGWATPDIFDPAFRDALTRLNKGQMSAPVHSSFGWHLIELLDTRNVDKTDAAQKDRAYRMLMNRKFSEEAASWMQEQRASAYVKILSN
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: RL19_MAGSA
Sequence: MVNIIEQLEKEQIEKLTADRGVPSFAPGDTLKVNVKVIEGNRERVQAYEGVCIARKNDGLNSSFVVRKISYGEGVERIFPLYSPNIASIEVVRRGDVRRAKLYYLRDRRGKSARIAEQTTGHSGKVAAAERADAAAVKAAKVAAAKVE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: HES1_XENTR
Sequence: MPADLMEKNSSSPVAATPASMSNTPDKPKTASEHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTDVRTRLLGHLANCMNQINAMNYPTQPQIPAAAAPHPAYGQPLVQLQGAAPQSSPAPIACKMGGPPVEAAKVYGGFQLVPAPDGQFAFLITNPAFPHNGSVIPVYTNSNVGTALPPSVSPSVMPSVTADSVWRPW
What is the function of this protein?
Transcriptional repressor of a subset of early mesodermal genes including myod1 and t/bra.  Binds DNA on N-box motifs: 5'-CACNAG-3'.  Acts as a negative regulator of myogenesis, mediating Notch signaling to repress expression of myod1 (By similarity).
What are the official names of this protein?
Transcription factor HES-1, Hairy and enhancer of split 1, Protein hairy-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: KRBX5_HUMAN
Sequence: MGLLTFRDVAIEFSREEWEHLDSDQKLLYGDVMLENYGNLVSLGLAVSKPDLITFLEQRKEPWNVKSAETVAIQPDIFSHDTQGLLRKKLIEASFQKVILDGYGSCGPQNLNLRKEWESEGKIILW
What are the official names of this protein?
KRAB domain-containing protein 5.
Protein: TLR3_BOSTR
Sequence: MSRPLPYHIYFFTGLLTCWILCTSSAHKCTVRHEVADCSHLKLTQIPEDLPTNITVLNLTHNQLRRLPPANFTRYSRLTILDGGFNSISKLEPELCQNLPWLEILNLQHNEISQLSDKTFVFCMNLTELHLMSNSIQKIQNDPFKNLKNLIKLDLSHNGLSSTKLGTQLQLENLQELLLSNNKISSLTPEELDFLGNSSLERLELSSNQIKEFSPGCFHAIGKLSGLSLNNAKLSPSLTEKLCLELSNTSIENLSLSSNQLDTISHTTFSGLKQTNLTTLDLSRSSLRVMDNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRHLNLRWSFTRQSISLTSLPKIDDFSFQWLKCLEYLNMEDNNFPSIKRNTFTGLVRLKFLSLSNSFSSLRTLTNETFLSLAGSPLLLLNLTKNKISKIQSGAFSWLGHLEVLDLGLNEIGQELTGQEWRGLDNIVEIYLSYNKYLELTTNSFTSVPSLQRLMLRRVALKNVACSPSPFRPLPNLVILDLSNNNIANVNDELLKGLEKLEILDLQHNNLARLWKHANPGGPVQFLKGLSHLRILNLGSNGFDEIPVEAFKDLRELKSIDLGMNNLNILPQSVFDNQVSLKSLSLQKNLITSVQKTVFGPAFRNLSYLDMRFNPFDCTCESIAWFVNWINSTHTNISELSNHYLCNTPPQYHGFPVMLFDVSPCKDSAPFELLFMINTNILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRAEQFEYAAYIIHAYKDRDWVWKHFSPMEEEDHTLRFCLEERDFEAGVLKLEAIVNSIRRSRKIIFVITQNLLKDPLCKRFKVHRAVQQAIEQNLDSIILIFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERVNAFHHKLKVALGSRNSAH
What is the function of this protein?
Key component of innate and adaptive immunity.  TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms.  TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection.  Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
What are the official names of this protein?
Toll-like receptor 3.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome.
Protein: SALA_DROME
Sequence: MKLLIALFALVTAVNAQNGFGQVGQGGYGGQGGFGGFGGIGGQAGFGGQIGFTGQGGVGGQVGIGQGGVHPGQGGFAGQGSPNQYQPGYGSPVGSGHFHGTNPVESGHFHENPHEYPEHHGDHHREHHEHHGHHEHHGHHRH
What is the function of this protein?
Likely to be involved in the establishment of the head.
What are the official names of this protein?
Protein spalt-accessory, Protein spalt-adjacent.
Protein: MCPT2_MOUSE
Sequence: MQALLFLMALLLPSGAGAEEIIGGVEAKPHSRPYMAYLKFTTKNGSKERCGGFLIAPQFVMTAAHCNGSEISVILGAHNINKNEPTQQIIKTEKTFVHPKFQYLSGFYDIMLLKLQKKAELNSDVDVISLPSSSDFIKPGKMCWTAGWGKTGKNNPLSVTLREVELRIMDQEACKDHSDYDYQLQVCAGSPTTSKSIGQGDSGGPLVCDSVAHGIASSYEAKAPAVFTRISYYLPWIYKVLKSK
What are the official names of this protein?
Mast cell protease 2, mMCP-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Granzyme subfamily.
Protein: URED_YERPE
Sequence: MTAQSQNIVETPSRVRAHALGVNAPELAKYQDEPAQMRSGAVGKSGYLKLRFAKREHCSILAEMERRVPSLVQKALYWDEEIPELPCVTMISTSGCILQGDRLATDVHVEAGACAHVTTQSATKVHMMNANYASQIQNFIVEEGGYLEFMPDPLIPHRNSRFITDTTISIHPTATAIYSEVLMSGRKYHHADERFGFDVYSSRVAAQNLAGKELFVEKYVLEPKVESLDAVGVMQTFDAFGNVILLTPKEHHDRILARVPAHFDIKGGDCQRRDAST
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Putative urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADJ_VIBC3
Sequence: MDNNNAFQLSFDEQHYAWLAIDVPGEKMNTLQAAFAEEMQAVFATLNEKRGQIKGLIIHSLKPDNFIAGADVRMLEACQSVHEAQALASQGQQMFQQLADLPFPVVAAIHGPCLGGGLELALACDYRVCTEDEVTRLGLPEVMLGLLPGSGGTQRLPRLIGLLPALDLILTGKQLRAKKAKKLGVVDACVPHSVLLDVAKRLLEEKGHKKRAQVTLPIKEKLLANTGLGRKLIFDQAAKKTQQKTRGNYPAAQAILEVIQYGLEKGMHAGLEYEAKRFAELVMTRESKALRSIFFATTEMKKDLGADAKPAPVAAVGVLGGGLMGAGISHVTVAKAKTSVRIKDVANDGVLNALNYNYKLFDKQRQRKILTKAQLQAQMSQLSGGTGFVGFDRCDVVIEAVFEDLKLKQQMVADIEANAKPTTIFATNTSSLPIHQIASQAQRPQNIVGLHYFSPVEKMPLVEVIPHATTSDETIATVVTLARKQGKTPIVVKDCAGFYVNRILAPYMNEAAQVLMAGEPIEKLDAALLDFGFPVGPITLLDEVGVDIGAKIMPILVKELGPRFQGPDVFDVLLKDNRKGRKSGKGFYTYKGSKKKEVDKSVYKLLKLTPESKLNDKEIAMRCLLPMLNEAVRCLDEGIIRSARDGDMGAIFGIGFPPFLGGPFRYMDTLGLTKVVEMMNQHTEKYGERFAPCDGLLTRAGLGEKFYP
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_LIMRD
Sequence: MSVKIRLKRMGSKKRPFYRIVVADSRAPRDGRFITSVGTYNPLTTPKEVKFDEDAVMEWLQKGAQPSDTVRNMLQAAGVMKKYHEAKYAKK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: CA174_DANRE
Sequence: MRAKQTVVVSLGQRVCGAVSLNPPGVKSSVKKAAKRRVLLQRSAPDIARAVRQMAGDGGEAKRLPKRPFHGEVEENSSAAVDGNVKIQPGKKAPGERRGKENSAAKCTGLTSGSAEAKMEQSVHGSQTTDPSVFFDEDSNHVFPVEQFFGNLDVVEDYPRRTPGSKRMTRREYRSMHYYAKEDSEEEHL
What are the official names of this protein?
UPF0688 protein C1orf174 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0688 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLYA_SHEFN
Sequence: MLKKAMNIADYDPELFKAIEDETCRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVVETLAIERAKELFGATYANVQPHSGSQANSAVFMALLQPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIIPYGIDEAGKIDYDEMERLAIEHKPKMIIGGFSAFSGIVDWARMREIADKIGAYLFVDMAHVAGLIAAGVYPTPVPHAHVVTSTTHKTLAGPRGGIIISAADDEVLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKVYQQQVVKNAKAMVEVFLARGYKIVSGGTENHLMLVDLIGRDLTGKEADAALGSANITVNKNSVPNDPRSPFVTSGIRIGSPAITRRGFKEAEAKELTGWICDILDDATNTVVTDRVKGQVLALCARFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIC_PSE14
Sequence: MTQQSPAFISPIWLKREQLIDVPEPIMLDWLFNQDSLTRRLDRLSDGGFSVFPQFEGWQALRRDECLALGLPLASEGWVREVYLCGNDSNWVFARSVAARSALQDGGLNMDELGTRSLGELLFSDPAFARGTLEVCHYPEAWLPDAVAARGLWARRSRFSRGALSVLVAEVFLPALCNTIHDKDPV
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMG_ECO55
Sequence: MFDVLMYLFETYIHTEAELRVDQDKLEQDLTDAGFDREDIYNALLWLEKLADYQEGLAEPMQLASDPLSMRIYTPEECERLDASCRGFLLFLEQIQVLNLETREMVIERVLALDTAEFDLEDLKWVILMVLFNIPGCENAYQQMEELLFEVNEGMLH
What are the official names of this protein?
Protein Smg.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: PHNX_BACAH
Sequence: MKIEAVIFDWAGTTVDYGCFAPLEVFMEIFYKRGVGITAEEARKPMGLLKIDHVRALTEMPRIANEWNRIFGQLPTETDIQEMYEEFEEILFAILPRYASPIHGVKEVIASLRERGIKIGSTTGYTREMMDIVAKEAALQGYKPDFLVTPDDVPAGRPYPWMCYKNAMELGVYPMNHMIKIGDTVSDMKEGRNAGMWTVGVILGSSELGLSEEEVENMDSAELREKIEVVRNRFVENGAHFTIETMQELESVMERIEKQELIIS
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
Phosphonoacetaldehyde hydrolase, Phosphonatase, Phosphonoacetaldehyde phosphonohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PhnX family.
Protein: RL34_SHIBS
Sequence: MKRTFQPSVLKRNRSHGFRARMATKNGRQVLARRRAKGRARLTVSK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: ISPE_ANASK
Sequence: MRLVTLAPAKVNLVLRVGPVRADGYHDLRTLMVPLDLGDRVDVRVSARPGPVRCTVPGRPELDGPENLAARAAEAFRRRFGVDRAVSIRIEKRTPVTAGLGGGSSDAAAVLRCLARALRVRDGAALAALALEIGSDVPFFLGPGPAWAAGRGERLSRAEVPPLDLVLVYPADPSLAIRAGDAYRWLDEARASGSQAPRRLGRPGRWRPTLLGNDLQAPCVARKPALQALLGLLVGAGATAAIMSGSGPTVFGIFPGRGAARGAALAIQGRAKGGAAGVQVLLARTVRRHPRVSPWRSPRSASSRSTRRSSRPT
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: ARLY_SALPK
Sequence: MALWGGRFTQAADQRFKQFNDSLRFDYRLAEQDIVGSVAWSKALVTVGVLTADEQRQLEEALNVLLEEVRANPQQILQSDAEDIHSWVEGKLIDKVGQLGKKLHTGRSRNDQVATDLKLWCKETVRELLTANRLLQSALVETAQVNQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLARDESRLQDTLKRLDVSPLGCGALAGTAYEIDREQLAGWLGFASATRNSLDSVSDRDHVLELLSDAAIGMVHLSRFAEDLIFFNSGEAGFVELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCQEAAQQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGKPLEALPLADLQKFSRVIGDDVYPILSLQSCLDKRAAKGGVSPQQVAQAIDDARARLAL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDC37_TETFL
Sequence: MSRIDYSVWDHIEVSDDEDVSHPNIDTPSLFRWRHQARVERMEDFKKKGDDLNKGLQECRRKLAEAQKKVRELSISAAGDAKAELTKTQTEEKKLKKEERDWARKLEEHNHEEKKMPWNVDTLSKDGFSKSIVNVKADSAEDTEEEKEKKHKTFVERYEKQIKHFGMLHRWDDSQRYLSDNPDLVCEETANYLVIMCIDLEVEEKHALMEQVAHQTIVMQFILELAKSLKVDPRGCFRQFFEKIKTADQQYQDAFNDELESFKERVRGRAKIRIEKAMKEYEEEERQKRLGPGGLDPVEVYESLPPEMQKCFDEKDIQMLQDVITKMDPTEAKAHMKRCIDSGLWVPNSKMDESDEKEDGSTYEEVKQEQEEPAKKE
What is the function of this protein?
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
What are the official names of this protein?
Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, p50Cdc37.
What is the protein family that this protein belongs to?
Belongs to the CDC37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_PARTE
Sequence: MNHKRIALNYFYFSMWTGLSGAALATMIRLEMAYPGSPFFKGDSIKYLQVATAHGLIMVFFVVVPIFFGGFANFLIPYHVGSKDVAFPRLNSIGFWIQPLGFLLVAKIAFLRTTSWKYYDKTSFFLQPYNKSLYRDFFNFLTGELSFNPFKKSLDESLFLFLWKPRKKITNTEYTSFFFNPLNLSFLDSFFYYSDNLWSLANKVVSSRRKKIYVTKCSNRAAVTAGWTFITPFSSNMKYSGFGAQDVLSVAVVLAGISTTISLLTLITRRTLVAPGLRNRRVLIPFITISLLLTLRLLAIVTPILGAAVLMSLMDRHWQTSFFDFAYGGDPILFQHLFWFFGHPEVYILIIPSFGVANIVLPFYTMRRMSSKHHMIWAVYVMAYMGFVVWGHHMYLVGLDHRSRNIYSTITIMICLPATIKLVNWTLTLANAAIHVDLVFLFFCSYVFFFLTGGFTGMWLSHVGLNISVHDTFYVVAHFHLMLAGAAMMGAFTGLYYYYNTFFDVQYSKIFGFLHLVYYSAGIWTTFFPMFFLGFSGLPRRIHDFPAFFLGWHGLASCGHFLTLAGVCFFFFGIFDSTSENKSSILANFGIPKIAKRAHLYFFKISYNNYTNEIASELPKVEVRKFIIENTFGEYECVKLVPVTK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NDHK1_SYNY3
Sequence: MSPNPANPTDLERVATAKILNPASRSQVTQDLSENVILTTVDDLYNWAKLSSLWPLLYGTACCFIEFAALIGSRFDFDRFGLVPRSSPRQADLIITAGTITMKMAPALVRLYEEMPEPKYVIAMGACTITGGMFSSDSTTAVRGVDKLIPVDVYIPGCPPRPEAIFDAIIKLRKKVANESIQERAITQQTHRYYSTSHQMKVVAPILDGKYLQQGTRSAPPRELQEAMGMPVPPALTTSQQKEQLNRG
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K 1, NAD(P)H dehydrogenase I subunit K 1, NDH-1 subunit K 1, NDH-K 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CX7A1_BOVIN
Sequence: MRALRVSQALVRSFSSTARNRFENRVAEKQKLFQEDNGLPVHLKGGATDNILYRVTMTLCLGGTLYSLYCLGWASFPHKK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 7A1, mitochondrial, Cytochrome c oxidase subunit VIIIc, VIIIC, Cytochrome c oxidase subunit VIIa-heart, Cytochrome c oxidase subunit VIIa-H, Cytochrome c oxidase subunit VIIa-muscle, Cytochrome c oxidase subunit VIIa-M.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIa family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: MCPU_PSEPK
Sequence: MPLRRLSIQWKITLLAGLCLLAIVALLVATSLTQAHRSAALVNQANTAMLEDSARQRLQAHAETQALRIQRYFMDAYQYGNGFARLVQVLKDRGGSDLRAELTRQARASLAGNPDVIGLYLVFQPNALDQQDSHYLGQDAMGSNESGRFSLYWSQPSPGTLELEAMPETMLGDTSIGSNGAAKNRWLTCPQDTARTCMLEPYLDEVNGRQVLMTSIALPLLEHGKVVGVVGLDIGLANLQQLSVNGRRDLFDGQGQVSIATAAGLLAGNSRDDSVLGKPMDKSVADGLLRVAHPFTPIPDTAPWQVVLELPESVLQAPAVALNQRLDAHNQNANLTSLLIGLGTAIAGLLLVWLTARGVTRPILAVAARLEDIASGEGDLTRRLDYAHQDELGQLTGWFNRFLDKLQPVIAQVKGSLQEARNTADQSAAIASQTSDGMQQQHREIEQVATAANEMSATALDVAHNASQAAQAARAADQASQEGLQLVDSTRQGIDRLAAGMNTAMDEARALEDRSGQIGSVLEVIRTIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRGLAQRTQVSVEEIRQVIEGLQQGTQDVVGAMHAGQRQAQDSAARMEQALPALQRIGEAVAVISDMNLQIASAAEEQSAVAEEVNRNVAGIRDVTESLAGQADESARISQALNRLANQQQALMEQFRV
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.  McpU is a chemoreceptor that binds and mediates chemotaxis to polyamines such as putrescine, spermidine, cadaverine and agmatine (PubMed:26662997, PubMed:30425146).  Also binds histamine and ethylenediamine with much lower affinities (PubMed:30425146).
What are the official names of this protein?
Methyl-accepting chemotaxis protein McpU.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS12_RHOPB
Sequence: MPTINQLIASPRVVQKSRKKVPALQQSPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHILRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.