PharMolix/UniProtQA huggingface dataset:
Protein: YM008_YEAST
Sequence: MYDLLEQKFFVREIKFASAYYLRTGKALNNSKTPIFQRKHSLPAWLSSAVIITAPVSNDGSHSILFARKTLRMIMPMFSPLFNRSPDDCPSHLTATHIFQQFSAMLDYGQSTKEATNKRRLIKGSDLLVALDRNCIPSAPFVPEIALRKSGAVGS
What are the official names of this protein?
Uncharacterized protein YMR008C-A.
Protein: RDM1_MACFA
Sequence: MAELVPFAVPIESDKTLLVWELSSGPTAEALHHSLFTAFSQFGLLYSVRVFPNAAVAHPGFYAVIKFYSARAARRAQKACDRKQLFQKSPVKVRLGTRHKAVQHQALALNSSRCQELANYYFGFNGWSKRIIKLQELSDLEERENEDSMVPLPKQSLKFFCALEVMLPSYDCRSPGVGLVEKPVDKVEEGPLSFLMKRKTAQKLAIQKALSDAFQKLLIVVLESGKIAVEYRPSEDIIDVRCEEELHGLIQVHCSPWKQCGQEEEEYLSDFSLEEEEFRLPELD
What is the function of this protein?
May confer resistance to the antitumor agent cisplatin.  Binds to DNA and RNA (By similarity).
What are the official names of this protein?
RAD52 motif-containing protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, nucleolus. Nucleus, Cajal body. Nucleus, PML body. Note=After treatment with proteasomal inhibitors and mild heat-shock stress is relocalized to the nucleolus as dot-like or irregular subnuclear structures. Colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress. Relocalized in nucleolar caps during transcriptional arrest (By similarity).
Protein: GATC_AKKM8
Sequence: MSTPQIDVAYIAKLARIDLTEEETALFSKDLDKVLAYITKLESYDVTGIAPMNHPLPAMDVMREDIPETGFTQEEALSNAPQQSQGQFRTPKVVESA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: RL28_MARMM
Sequence: MARRCELTGTGVLTGNNVSHAQNKSRRRFLPNLCDVTLASEKLGRGFKLRVAAKALRSVDHVGGLDVYLLKARDEKLSDKALKIKRDLKKAMAA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RPOA_LEVBA
Sequence: MIEFEKPNIHKIDESNNYGKFIVEPLERGYGTTLGNSLRRILLSSLPGAAVTSIQIDGVLHEFSTVEGVVEDVTQIILNVKKIALKLNGSDDQEETMEINVKGPAQITAGDIVAGADVDILNPDLYIATVADGATFHMRMTADKGRGYVSADENKTRNTDMPIGVLAVDSIYTPIERVNYQVENARVGQRADYDKLTLDVWTNGSINPSEAIALAAKILTEHLAMFVDLTDEAKNAEIMVEKEETHKEKMLEMTIEELDLSVRSYNCLKRAGINTVQELNNKTEADMMKVRNLGRKSLEEVKAKLADLGLSLRKED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: CMOB_SALA4
Sequence: MIEFGNFYQLIAKNHLSHWLETLPAQIAAWQREQQHGLFKQWSNAVEFLPEITPWRLDLLHSVTAESETPLSEGQLKRIDTLLRNLMPWRKGPFSLYGVDIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHLWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALKAFDTVFSMGVLYHRRSPLEHLWQLKDQLVNEGELVLETLVVDGDENTVLVPGDRYAQMRNVYFIPSAPALKKWLEKCGFIDVRIADVCVTTTEEQRRTEWMVTESLADFLDPNDRSKTVEGYPAPQRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: POP2_YEAST
Sequence: MQSMNVQPRVLAVGGEQFFSQRQASEQHQQQNMGPQVYSPKVNRARMFPQGMPVNTINGSVNQEMNNAYLLKQKNEPLLTQQQQQQQQQQQPFNIGTPVSVASLPPGLNVLQQQQQQQQQQQQQQQGVGLNRPLASQLPKHLTNQSMPPIFLPPPNYLFVRDVWKSNLYSEFAVIRQLVSQYNHVSISTEFVGTLARPIGTFRSKVDYHYQTMRANVDFLNPIQLGLSLSDANGNKPDNGPSTWQFNFEFDPKKEIMSTESLELLRKSGINFEKHENLGIDVFEFSQLLMDSGLMMDDSVTWITYHAAYDLGFLINILMNDSMPNNKEDFEWWVHQYMPNFYDLNLVYKIIQEFKNPQLQQSSQQQQQQQYSLTTLADELGLPRFSIFTTTGGQSLLMLLSFCQLSKLSMHKFPNGTDFAKYQGVIYGIDGDQ
What is the function of this protein?
Acts as probably catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.  In vitro, POP2 has 3'-exoribonuclease activity with a preference for poly(A) RNAs, but also degrades poly(U) and poly(C) RNAs.  Is part of a glucose-sensing system involved in growth control in response to glucose availability.
What are the official names of this protein?
Poly(A) ribonuclease POP2, CCR4-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the CAF1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: UNC5_DROME
Sequence: MAVINKAGNVIALLLVKLQLILLFTLSVSGELPQLDYGSLSASLEEDAIDPLTAMAPFANSLVTEESAQHKNNAELLGNSSEDENVRPQQGSSSSGLGSSGAAGGSGILLEEFNSGKLSPGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVIFKCSGSSQPPPSTHETHVDPHTGVNMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQAATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVITADSEPGITVSAGTLIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWRECKCAGKPSQGRKRSRTCNNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSICSAECIQVRRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSDIIPGYGKSLCAGKDIQTAECRGEQCQIGKDDFDWTLYLGLAFITAVCFAFGTALICCARRGIRTNPHYNMARSVMDADYMPGVVEKKEMRMHIEASNMGYDYVNPGHRYLPGEHIMGMGIGCGGVTEHHYDVPNLSANYTNPIDHLSVDYLSETGESSTADTSNSTFDMNGKLSILNASKSSTYEMLGSAGGQLRLYGGELLLFVPEHAIGKHVKKHVSLLLLSDECSRVSCATESSILCSSVVHSAPRNYSFVKPVILKIPHCLVAPEQWHVHIYHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPRIQQPSIKMKLLAFSQHTPPSNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLNSRNLNIRVRSADVEAAAPYEHAIPYQHILSNNSILHCEFSLRRQDQNSLCVDFGQGSEDDYYTFNIPAHSMSGSAEELASTTNTTISIDRQGNYVNESCVMDFVQLPHATKRLICGALDPPRADERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSSPGSSSNSVSHTIMALLLTLKEMGRQDVLDIIVETIGPLWI
What is the function of this protein?
Receptor for netrin required for motor axon guidance.  Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding.  Also involved in glial migration.  While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5.
What are the official names of this protein?
Netrin receptor unc-5, Unc5 netrin receptor.
What is the protein family that this protein belongs to?
Belongs to the unc-5 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PUR5_GEOTN
Sequence: MVKAYKQAGVDIEAGYQAVALMKQHVQKTMRPEVLGGIGGFGGLFDLSSLDYRQPVLVSGTDGVGTKLKLAFLLDRHNTIGIDCVAMCVNDIVVQGAEPLFFLDYIACGKAVPEKIAAIVKGVADGCVEAGCALIGGETAEMPGMYAEDEYDLAGFVVGIAEKERLVTGQTIQAGDVLIGLPSSGLHSNGYSLVRRIIFEQAKLSLDEIYEPLDVPLGEELLKPTRIYAKLLRSVLGRFTIKGMAHITGGGFIENIPRMLPQGLGVRIQRGSWPVLPIFDFLRAKGNLEEEEMFSVFNMGIGLVLAVSPETAAPLVQWLDEQNEPAYIIGEVVEGAGVSFTGGNEA
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_SHEAM
Sequence: MESQRNLLLIGLLFVSFLLWQQWESDKAPKPATEVTAAAQIHDQAINSDVPTADAGVPATVAATQNLILVTTDQLEIQINPVGGDIVHAALLTHKLEQNEEAPFVLLEQKNNFSYIAQSGLIGRDGIDSAASGRAKFAAAADAYTLADGQDTLEVPLTLTTDAGVTFTKVFVFKRGQFDVGVDYRVANNSAAPVQVQMYGQIKQTITASESSMMMPTYRGAAFSTADVRYEKYSFDDMGKKDLEEPTLGGWVAMLQHYFVSAWVPAAADKNTLFTSVSAGGLANIGFKGSVHDVAPGATETISATFYVGPKDQAALSALSDTLNLVVDYGFLWWLAVPIHWILMFFQSLVHNWGVAIILVTLTVRGLLYPLTKAQYVSMAKMRNLQPKLQDLKDRFGDDRQKMGQAMMELYKKEKVNPMGGCLPILLQMPIFIALYWVLLESVELRHAPFMLWIQDLSVQDPYYVLPLLMGASMWAMQKMQPMAPNMDPMQQKMLQWMPMIFTVFFLWFPAGLVLYWLVGNLVAITQQKIIYASLEKKGLK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PGS2_SHEEP
Sequence: MKATIIFFLVAQVSWAGPFQQKGLFDFMLEDEASGIGPEERFHEVPELEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRAAVQLGNYK
What is the function of this protein?
May affect the rate of fibrils formation.
What are the official names of this protein?
Decorin, Bone proteoglycan II, PG-S2, PG40.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: TRPA_YERP3
Sequence: MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLADGPTIQNAALRAFAAGVTPAICFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAEVGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADDDLLREIASHGRGYTYLLSRAGVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKIIEKNVAQPVEMLVQLTRFVTEMKAATRS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: PRVB1_ONCMY
Sequence: ACAHLCKEADLKTALEACKAADSFNFKTFFHTLGFASKXXDDVKKXXXVLDQDASGFLEVEELKLFLQNFCPKXXXLTDAETKAFLKAGDADGDGMLGLDEFAVLVKQ
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions.
What are the official names of this protein?
Parvalbumin beta 1.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: LTG14_ARATH
Sequence: MESRKINLMATAIALIVVAMVVAAADDKTKDKEECTEQLVGMATCLPYVQGQAKSPTPDCCSGLKQVLNSNKKCLCVIIQDRNDPDLGLQINVSLALALPSVCHAAADVTKCPALLHLDPNSPDAQVFYQLAKGLNKTGPASAPTGSSPGPISISPTSGSDDGNNSGRTTSVPGRNHAQSFYKQWLGLEVVFHFFVIFYIFILV
What is the function of this protein?
Probable lipid transfer protein.
What are the official names of this protein?
Non-specific lipid transfer protein GPI-anchored 14, AtLTPG-14, Protein LTP-GPI-ANCHORED 14, Protein SENESCENCE ASSOCIATED GENES 27, Xylogen like protein 7, AtXYLP7, AtXYP10.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: LPXK_BURCJ
Sequence: MSAPGGPLARLEARLTREWQRRGALAWALTPFACVFGLCAALRRTAYAQGWKQPVDVGVPVVVVGNVTVGGTGKTPTVIALVDALRAAGFTPGVVSRGYGANVKAPTAVTPASRAGAAGDEPLLIARRTGAPVWVCPDRVAAAQALRAAHPDVDVIVSDDGLQHYRLARTVELVVFDHRLGGNGFLLPAGPLREPLSRHRDATLVNDPYSSALPPWPDTYALALTPGAAWHLDQPTLRRPLSQFANERVLAAAGIGAPERFFATLRAAGLAPATRALPDHYAFADNPFVDDAVDAILITEKDAVKLGASWRDARLWVVPVEAALDPRLIALVVEKLRGRSPA
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: VMA21_NEUCR
Sequence: MATRRIISQEKTLLEKDDRIGSSPAASEKSNITPAVPASVIIKLLAFTFAMIVIPISSYFLTVDRLFKGNSTYAGATAAIMANVVLIGYIIVAMAEDQSDQENEKKGGGGKGEGKKDL
What is the function of this protein?
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
What are the official names of this protein?
Vacuolar ATPase assembly integral membrane protein vma-21.
What is the protein family that this protein belongs to?
Belongs to the VMA21 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Protein: MSRAB_ENTFL
Sequence: MGAIMQANENMGSKLPKTDGKVIYLAGGCFWGLEAYMERIYGVVDASSGYANGKTQSTNYQKLHESDHAESVKVVYDPKKISLDKLLRYYFKVVDPVSVNKQGNDVGRQYRTGIYYVDNADKKVIDNALKELQKSVKGKIAIEVEPLKNYVRAEIYHQDYLKKNPNGYCHIDLKKADEVIVDSDKYTKPSDEVLKKKLTQLQYEVTQNKRTEKPFENEYYNKEEEGIYVDITTGEPLFSMADKYDSGCGWPSFSKPISKDVVKYEDDESLNMRRTEVLSRIGKAHLGHVFNDGPKELGGLRYCINSASLRFIPLKDMEKEGYGEFIPYIKKGELKKYIHDKTH
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase msrA/msrB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
Protein: TTCA_BRUSU
Sequence: MNAFDADITEHADSSGCHPLFRDVPATVEFNKLRKRLLRLTRQAIEDFAMVKPGDRWMVCLSGGKDSYGLLALLLDLKWRGLLPVELLAVNLDQGQPNFPKHILPDFLTRYGIEHRIEYQDTYSIVTDKLPETSTYCSLCSRLRRGNLYRIAREEGCSAIVLGHHREDILETFFMNLFHGGRLAAMPPKLLNDEGDLMVFRPLAYAAEDDLEKFANAMQFPIIPCDLCGSQDGLQRNAMKAMLIDIEKRMPGRKDTMIRALTNVRPSHLLDRKLFDFAGLMANGEKGSDDALW
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10L_BOVIN
Sequence: MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDKVAKKRLIPDGCGVKYVPNRGPLDKWRALHS
What is the function of this protein?
Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (By similarity).  Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity).
What are the official names of this protein?
60S ribosomal protein L10-like.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CML24_ARATH
Sequence: MSSKNGVVRSCLGSMDDIKKVFQRFDKNGDGKISVDELKEVIRALSPTASPEETVTMMKQFDLDGNGFIDLDEFVALFQIGIGGGGNNRNDVSDLKEAFELYDLDGNGRISAKELHSVMKNLGEKCSVQDCKKMISKVDIDGDGCVNFDEFKKMMSNGGGA
What is the function of this protein?
Calcium-binding protein that may positively regulate abscisic acid (ABA) inhibition of germination and seedling development.  May be required for photoperiod-induced flowering and function in ion homeostasis.
What are the official names of this protein?
Calcium-binding protein CML24, Calmodulin-like protein 24, Touch-induced calmodulin-related protein 2.
Protein: TIG_FINM2
Sequence: MSAVLVSKENNQAVFTCEIPAEDFNNAIEESYKKNRSRFSLKGFRKGKVPRKMLERAYGEGLFYEDAVNLLLPGIYEKAIEELELEPVSQPDIDLDDITENNDVKVKFTVDLKPEFELGDYSKLSAEIEEFKVTDSDVDMKVNHELESNARVQEVEGREAKENDTVSINFKGFVDDKAFDGGEAEDYELVLGSHTFIPGFEEQIVGHNAGDEFDVNVKFPEDYHEDSLKGKDAKFECKINSIKEKVLPELDDEFVKDVSEFDTLDEYKKDIKEHLEKDNEQRQLVEKQNKAVEALIEATEISVPESMIDNEVNRQFQDFARRVQQMGLNTDQYFQITNTSEEDVKNELRANAELKVKGDLVLEKYIEKEAIESTDEELDEQLKEFAKVYGKDDEEKFIEEFKNSPNVEFLKEDIKRKKALEKLVENTKFEIKKAEEKEDK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: LEUC_ACIB5
Sequence: MAGKTLYDKLWDDHVVTQRDDGSCLLYIDRHLLHEVTSPQAFEGLQLAGRQPWRLSANVATPDHNVPTSKKERDQGIAGIEDDTSRIQVQTLDDNCKAFYIVEFGINDIRQGIVHVVGPEQGLTLPGMTVVCGDSHTATHGAFGCLAHGIGTSEVEHVLATQCLVQKKSKNMLVRVDGVLGKGVTPKDVVLAIIGKIGTAGGTGYAIEFGGQVFRDMSIEGRMTVCNMAIEAGARVGMVAVDDKTIEYVKGRSYAPKGEQWEQAVAYWNTLHSDDDAVFDAVVELNGAEIEPQVSWGTSPEMVIPVSKAVPTLEQAKDDVQRNDWTRAYQYMGLNAGQALADIQLDRVFIGSCTNSRIEDIRAAAEVVKGRKVAPSIKQAMIVPGSGLVKQQAEKEGLDKIFLEAGFEWREPGCSMCLAMNADKLQPGEHCASTSNRNFEGRQGNGGRTHLVSPAMAAAAAIAGHFVDVRSF
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: APF4_GIBF5
Sequence: MSIPLPHAEFQWDHYDSKVNPVNGHVECTYRTLTCSWSAPRFVESPFLQVHGLAPGLNYGQQAFEGLLAHRTARNRILIFRPASHSSRFRHSASVVSMPPVPESLFLACVHMAVARNAEFVPPHNFAGNMYIRPLEFGSSAQIGLDVPDEFTFCVFVQPHVPLHGHTPLRALVAEEFDRAATRGTGNCKVGGNYGPVLKWSKDAKKPENGGWSALLHVDSKTQSYVDEFSAAALIGVKSPDQESTQVPILTVAHSEAAIHSITAESVVTIAQSFGWTVERRLVKLEELSSFSEVFAVGTAATIRPCSLIYHRSTGKHFTFTSDGPYYQRLWKTLSGIQKGEIEDIFQWCQDLRFEEFGERGHNGQPTADPTRVIEMPE
What is the function of this protein?
Aminotransferase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF) (PubMed:25058475).  The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L-phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L-2-aminooctanedioic acid (PubMed:25058475).  L-Phenylalanine is the only proteinogenic amino acid directly used by apf1 (PubMed:24195442, PubMed:25058475).  The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster (PubMed:25058475).  Lysine is converted to delta-1-pyrroline-5-carboxylate (P5C) which is reduced to L-pipecolic acid (L-pip) by apf3 (PubMed:25058475).  L-pip is epimerized to D-pip, probably by apf1 activity, prior to incorporation (PubMed:25058475).  L-Tryptophan is N-oxidyzed by one of the cytochrome P450 monooxygenases (apf7 or apf8), and further methylated at the hydroxy group by the O-methyltransferase apf6 to yield N-methoxy-L-tryptophan (PubMed:25058475).  The synthesis of the fourth apf1 substrate is more complex (PubMed:25058475).  The fatty acid synthase apf5 is involved in the synthesis of the octanoic acid backbone of L-2-aminooctanedioic acid by fixing one acetyl-CoA unit and three malonyl-CoA units (PubMed:25058475).  Then one of the cytochrome P450 monooxygenases (apf7 or apf8) may oxidize this backbone to 2-oxooctanoic acid (PubMed:25058475).  The aminotransferase apf4 is predicted to catalyze the exchange of the keto group with an amino group (PubMed:25058475).  The next step would be the oxidation of 2-aminooctanoic acid by one of the cytochrome P450 monooxygenases (apf7 or apf8).  The last step is the oxidation of 2-amino-8-hydroxyoctanoic acid to 2-aminooctanedioic acid is catalyzed by the FAD-dependent monooxygenase apf9 (PubMed:25058475).
What are the official names of this protein?
Aminotransferase apf4, Apicidin F synthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: AMN1_YARLI
Sequence: MQPSTPKRSKGDWSTTQQRRSYSTPSALIFGSPEDTPASSSSFASSSSTGTTPNTSPQRPSQLPKSPSSPTPSRRGLRGKLASLTLGAAERVRSISGRIDDREPPVYAPPAQPLANPQESLMGWMVERNNGGTRPQQRHPPPRLDTSNYGVSAISNNGLLTPEQTPESSPIQPIHRAKGRTTSYYQTQPFKYTSSLREDPFIDRNRNRIKEVQELDFEEFNNSEDDFCLSETDVHSEFSSSADSTSSQCHKALRIPEILYNILSHVEADVQVPHEPPPQRRRPLSLRHAFLIYGDREKAHQAWERALKEEQTPTQQMFKGDGALHGCLLVNKFWFEVSRKLLYNKLHFCDSQKWRQFVHMSSDTGSPEDLITWSRSSHHRSLSRSTGQPNLHQLANGEAEMNDYFDTPTKLFVLHKISNAQQSEIDLLQHKIGGALEWLEFYTCAAIVPPLGLLAGGSLQKIVLPGCTKVDDAFLKLVAENCPRLQIADLRACEKVSNEGLVALAGKCPQLKLLNVGRTQMGHLISYRGISAIARKTQVNTLGAAGCFVCDKSMWELAWYRGHSLDRLSLNGCTLLTNDSIPRILPYTSNLAVLELRGCTQITDFKSIIKFKRYQERHKREPLIEGCEIFESRMREAEFQLEMDISREILRDCVQWIYAPDHDQESVRVKRKKVVPNFASTSRLSFIPHGSDAARKLAATSTRVESSSRHHSSRPSH
What is the function of this protein?
Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints.  Required for daughter cell separation and chromosome stability.  Involved in copper sensitivity.
What are the official names of this protein?
Antagonist of mitotic exit network protein 1.
What is the protein family that this protein belongs to?
Belongs to the AMN1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PT100_YEAST
Sequence: MGLFNNFKFKYTRAQLEIFRFSFCLLAPVAVMYYIGTDTDKKLNVPGFWPDPATLNQIPKEPYEIKAELARMKKERLEKRLRLEKKIQEEFGLDLEEEKEKIKRDLALKKG
What is the function of this protein?
Required for the biogenesis of cytochrome c oxidase.  Probably for its assembly into an active holoenzyme.
What are the official names of this protein?
Protein PET100, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PET100 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: GLK_XYLFT
Sequence: MNAPQAPVLVADIGGTNARFALANPTLTSAPLLNDSMREFAVIEFPSLGEAAQHYLHHIGIHTTKGVFAIAGHVDGDEARITNHPWVITRTRTATMLGFDTLHLINDFVAQAMAISVLGPQDVIQIGSAKWEQFPLSAATRNYGIIGPGTGLGVGGLMIRNGRCYPLETEGGHVSFPPSTPEEIRILEILSQQFGRVSNERLISGPGIVNIHRALSEIDGIDPGPLRPQDITMRAADGDIRATRTINLFCNIFGTITGDLVLIQGAWDGVFLTGGLVPKLLNSIQHSGFRQRFEHKGRFSAIMARIPSLAVIHPHPGLLGAAAYARDTEQVPQEIKA
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCGN_SALPK
Sequence: MSDTPFWQRKTLDEMTDAEWESLCDGCGQCCLHKLMDEDTDEIYFTNVACRQLNIKTCQCRHYERRFEFEPDCIKLTRENLPDFEWLPMTCAYRLLAEGKPLPTWHPLLTGSKAAMHGERISVRHIAVKESEVRDWQDHILNKPSWAE
What are the official names of this protein?
UPF0260 protein YcgN.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: Y978_ACIAC
Sequence: MLKYAIIFAIISLIAGALGFSGVAAGAAGIAKILFFLFLVVAVIFIVLAVLGVGAARSVMK
What are the official names of this protein?
UPF0391 membrane protein Aave_0978.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.