Protein: SDC2_CAEEL
Sequence: MSDESELGNQSEMESFNESDSPDEADPDVVIIHDIVHLRASTTGDYSQSEIGKLPEQNTFFLPGRVKRNISSNDSDVIIDEDEIPDGAIRITSDTHFIGSSRGTSELGDFEMDEQEFLNITIEENGNEQELEEHLRNAYRHEEEECFEEEDDIIELPPLPVKPAVKKPRRKLPKHLSIESGSTAKTSKLVAEVVHDHPRPVNYRMKPAVTDDGKVVEQKRTRVTRNIMSHTIPQYHLEGEETEFGRVKESTLSKTIEQYLQAGKLVSPKCDQFREQIVATAVEYDGSVKMLQFENALKKHSGKQKRLKYQTGWWKASKSHYERAVNGYVAMPKTPVLSISDDPVLYKHHSLFPKNQSSELEKINVQLRIRLNSKRQNNDVIPDSSYFVREFLMQKHSISLRMNRSSDLPELFVPPTLECGYFPQDAVTVQQQEHYLMMRFEEAQDEYHNITYRSIAPPVEFQVGTISAKELHKFHRIGRHIHGFFVVWENKFPEYDESGICCPRKRYLVDMFNLICFPLYTEYEQWESRLRVAFDKTIVYNLHLSEILRCNRPVFDFLSKNKSMLQPITLKEIVYLIEQSNMDAKSFAVKFGLRTFYDHGRATSNKDYLSAFLIITGGAKVVTEEIDSERLRVFNSDYMESGVLTSSGDVYTFEFDKIPNNYQISIGCNADGVAEMEQEDVRHELSECSSRITRIIGDSKKPEKIIARPLVKTNQNDGMKFFTRKDLLNYRIKLYDPSYVVPRAKKQIVNEPAKKKPGRKSKTRYDAAMQQNNFEIEGVPSDVDSEFEGYLSDSENVFQKPSKLMRSTSSDSVFIDYQYREKMFLDVSWFHQQKMIDRSLPPLKKRKRKMNRIYHKHSVRYTMLQANGCAFTEMYRCYDKILPCGTKEIARTKNAIRFPHRFRTYNIPQVYGPGDKQLITEVFGVVKDVITRATGFESASIRTANDIAQAVYDANIARRELLENLEPSDNGILPSPAYLAIEMLSHQKMSGRLCLESARKDVQNNVDKMYNDYMDLDPLDKELHFEISQSIRQSKLNESLEEYERNRERQLAKTLKTVPMDKRSQAALARREEKRRESRRKLADKYAEQRRMMASTRRLEKRTTQKQVDPETIQRLRREDEVRKRKRFEEEDRRGMIRRREERVALQEKVDRMLEEGLRLEKVREAERIRQQQEEERIEMETILISRRVREEEEEKMRLERLRKAEREREQERLKREEEEERKRLEQLREAEKLKAEIEKENERKLQEERTRKALELERKIEEIKRVSTLKDMFGPLPIAKENEQTEKDFQILLDDHELTLLTISRDPLNEKYQEARTEFERLDIKSMLLRKAEKLIDVLTIHYDVPIEQTCRYFTSSIESNENRMAVNEQLNKLFENMANCFTFNIQDGENGLQSKRKWDFQFKKCAVFDGVSQSTVNFIEEKMRENTKKKHLATPKTVISIDTSLLKQSLLRSHARFDPDISLYAQNHTANSIGDVTLKMSNYSLDFATQSIHDKELAEKATPKKGPTVRRHIKNLFGSEKVIVRRSLAAGKPASLNSEDSDSEDSREGSPVAEFLPTNPVCSFWKLVVKIENSTTDKEKTELCEDLDKLILRKDDLFSKSLKWMFPLLATFYVLLSNAVLNENEEIISDKNQTGVTKDEILKSTINDLMIIAAYFEEGSRERSNLRKMISMNGFSVVFNRVILFAKKTCTLAKELESNSRSLSGYVIEDLFESLLAEIERTMRQELGSSVRKTGKLERDFEEIVKLIQNEKKLALSHKSHKNDENRRFRLNTVVKWYDAIICHCKEELTQAIVDAFPLNAITKNKETSHVAMENGDDEAMLSDTSDNQMSTTDYQMPKNICRNSEIFPEDAFAKAYAVVRIPSKKERAQMLSVYRKKNAQSGCVENKGLSRMPKFEEPFVDSVWRTIEKRINNMTHSEEKQIKRFIPVSRSHKLNEKVKFYAMVMIQERDSRDTRLFNSKFQDDNLWHCYSKSSLNHEKMESRILQHIEHTVLSKSNFNQMKWSVQCVNGNKKDAIHYFTDLYKYRSESEFRSALSCGKLKFNFKVYTHLWFMGNLLPTSYNPDSHDDKLFVPCSGCTSGDVIIIHKCTCAYHNDTFSDKFIYANTSLPVGIDKVTRLVGRFVCEHGPSSFLILEHCSANVDANIPFESENVEFSAELRIVKRKTMHSQLVKTFAEEHTHLRDASRHRAISTVTLDSSGSGRSTRCEIFEDSPSEDENDENQLDTTRIGRKIDPIIVDSDKAYLIAEGERMALRIKRLLDPELQKFRSKNFVSRSKSVDAPKTSKQKTVIRRSQSVCDLNDVNEYAQKKVRNTKDSFATLFRDHEYSTRRTYEEQLNNELLDVVTTFGGASNVSADKKYNILASILAFEKEVQLVNDKNGELFKTVSNLVQRNSLQHVKGVILAEDNQTLRSTDNTSEVFPESKAVNEYLKFEIYKRKMMVNAKLMADTVKDLKLKHAEYRPFAKLIATYDSIFKFNVYLFEHFLNCISKHVFNPYAIYCEETRPTGTELSKFQLTLKLIETSMPTVLSMLFNTEPLRRQLSELSEIHKKVRSEDLACTIASLCRYAIERIRIPQTADKRLCDFSWLNSAEDHRETVSFIRLTLEHTLPDMKTENEQTRFVEFLKEAEGFHFSYKFVEAQCKTFVRNHGDSKQAFFTAFYNQNEAFYGSLQKFMSNGTIDPKMKLYYQHQAFLRLHNIVKKRSHIITSDDYHRSSDVCKAMLLSEIVSNPKIAQEAYISGSVLDRMYTSLCKIKAKMPLISPSYIGTSLTCFEDELLFSAVREAKVHTDTRVVFRSKSCMRPNEKAGDANFKTCKVTLLVNLETALLSMVFKSRDQSEIDKDDRLDIDILDEEVIKPIIDWNRIFETFIQPTYNTLFSRMEKRERVSILPENPLGRLENYAFTNPNQDKDCQAVLEYIDVASDTDAEESIEDPLDIVEMTLKRALPRSMSPSSKRRRMR
What is the function of this protein?
Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals (PubMed:2759421, PubMed:10364546).  Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development (PubMed:2759421, PubMed:10364546, PubMed:14660541, PubMed:11937488).  Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reduction of X-linked gene transcription and an equalization of X-linked gene expression between the sexes (PubMed:8939869, PubMed:8939870, PubMed:9458050, PubMed:9056777, PubMed:10364546, PubMed:14660541).  May confer protection against toxicity induced by heavy metals such as arsenite (PubMed:25204677).
What are the official names of this protein?
Sex determination and dosage compensation protein sdc-2.
What are the subcellular locations of this protein?
Chromosome. Note=Localizes specifically to X chromosomes in hermaphrodite (XX) embryos.