PharMolix/UniProtQA huggingface dataset:
Protein: TRPA_AZOC5
Sequence: MTTRITARFTELAAEGRPGLVTFITAGDPDYDTALSILRGLPEAGADVIEVGIPFTDPMADGPAIQAAGLRALKGGQTLAKTLDMVRAFRDENDTTPVVLMGYYNPIYIYGVPRFIADAKAAGVDGLIVVDLPPEEDNELCLPALDAGLDFIRLATPTTDEKRLPAVLAHTAGFVYYVSITGITGSATPDANAVAGAVARIKQHTTLPVAVGFGVKTPAQAAAIAAGADGVVVGSALVEAVRKTLDEDGKATVNTVPAVTALVQELAEAVRGVNRAAAE
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RS17_BORBU
Sequence: MARENKKELIGKVVSDKMSKTIVVEIVQRKMHPIYHKYLKVSKKVKAHDEKEVSKVGDKVKIIEVRPISKDKRWSLVEVLEKLK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: S17A4_MOUSE
Sequence: MSTGADLKAREGDIPSDNMTQEQSFKKGFCSLRHGLAFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERPPTNSQDVWNETLQESKAPVYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRYITCSLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKILRLVTIRKLFTAVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKGLLQVFSYLAGGIAPTVAGFFISQDSEFGWRNVFFLAAAIDVVGLLFYLIFSRAEVQDWAKEPTFTHL
What is the function of this protein?
Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions.  May be involved in urate extrusion from the intestinal duct.  May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates.  Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro) (By similarity).
What are the official names of this protein?
Probable small intestine urate exporter, Solute carrier family 17 member 4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Apical in the intestinal brush border.
Protein: SYS_BURO0
Sequence: MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTHTEELQARRNSLSKQIGAMKGKGEDTSAVMAEVGGIGDDMKASEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADNVEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGARFTMLRGPIARLHRALAQFMIDTHTQQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISLTNTVRESIVDGAALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPETSYAALDEMVGHAEAILQKLGLPYRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPEVLRPYMGGMERIDAPAQAS
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
Protein: UPP_ECOSE
Sequence: MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: YFGD_ECOLI
Sequence: MTKQVKIYHNPRCSKSRETLNLLKENGVEPEVVLYLETPADAATLRDLLKILGMNSARELMRQKEDLYKELNLADSSLSEEALIQAMVDNPKLMERPIVVANGKARIGRPPEQVLEIVG
What are the official names of this protein?
Uncharacterized protein YfgD.
What is the protein family that this protein belongs to?
Belongs to the ArsC family.
Protein: RAN_XENLA
Sequence: MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEQDLQNAQATALPDEDDDL
What is the function of this protein?
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:8413630).  Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis.  Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way.  Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport.  Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity).  RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446).  Required for normal progress through mitosis (By similarity).  In concert with nemp1a/b, required for proper eye development (PubMed:25946333).
What are the official names of this protein?
GTP-binding nuclear protein Ran, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ran family.
What are the subcellular locations of this protein?
Nucleus. Nucleus envelope. Cytoplasm, cytosol. Cytoplasm. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis (By similarity).
Protein: UPPP_LACP7
Sequence: MDFIELLKVIFLGIVEGITEWLPISSTGHLLLVDEFLKVNLSKDFMSMFNVVIQLGAILAVVVLFFKKLWPFSKEEKNFIKKDTFTLWFKIVVACIPGIVMIPFDSKIEDLFFNPQTIATTLILYGILFIIIENRNAGKQPKVAKLSDITYQMAFMIGLFQILAMIPGTSRSGATIIGAMLFGASRYVAAEFTFFLAIPTMFGASLLKLLKFGFTFTGAEIVALITGMLTAFIVSIIVIKFLMGYIKKNNFKVFGWYRIVLGAIVAGYFLLAR
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRUD_PSEF5
Sequence: MNELQLLGPRAYGDALGSAVLKATAEDFQVDEVLDIPLSGEGEHLWLWVEKRGLNTEEAARRIAKAAGVSLRTVSYAGLKDRQALTRQWFSVQLPGKADPDLGAAENHTLKILEATRHKRKLQRGAHAANGFTLRLTELKADQAAIDERLKRIAAQGIPNYFGAQRFGHDGGNLVDARSWAARQALPEQRNVRSRLLSTARSYLFNQALAARVADGTWQQAQVGDLLAFTDSRSFFMAGPDECTDPRLAILDLHPTGPLWGEGESPAGGAVHELEQQMADREAALCEWLIKAGMSHERRILRLPIGGLTWHYPEPDILQLEFVLPAGCFATALVRELVDLVPVGQTDSSCAF
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: HISX_CHLL3
Sequence: MSPVHYRTSTSTIVAVLKLYRFLDDRDALFRQIGRSVDFDPEVQRAVTDILEAVRLRGDMAVLEYTERFQGAVLTSMQVPEEDILRAREEADPAFIRVLEEAWENILRFHRHEVENSFFYEGEGGVVLGQRVTPMDRAMLYVPGGKASYPSSVLMNAAPARVAGVGEIFMTTPCDASGAVSPHILAAASVAGVTSVYRLGGAQAVAAFAYGTQTIPKVDIITGPGNKYVALAKKQVFGHVAIDSIAGPSEVVVVADDDADAEFITMDLFAQAEHDPDASSVLITPSMRLAEEVRDLAAARVGSMLRGEVIAEALSNNGAIVVVADIEEACRVSDMIAPEHLELHVLHPWELLASIRHAGAVFMGGYSCETVGDYYAGPNHTLPTNGTARFFSPLSVRDFVKHTSIISYTRRQIMACGERIASFADHEGLEAHAEAVRARLKKG
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: TIG_MESHJ
Sequence: MIKREFLPESAELKIKLTADSKKWAEFYQKAEQKQAAKVSLRGFRKGKVPLEKARAYLNPQAVFELALRMFLPELEKQAATNIIDSDNVIESPIFNIVNMDKNNLEIEFLYPVYPEIKLPDYKNLKTKFAIKKITKEDIELQKQKLLEAKGRFIEVNRPVKIGDVINFNFKGFIDDEPFDGGEGENFDLRIGSNSFIAGFEEQLVGLEIKKEADIYVTFPENYQVHTYANKKARFRVRINKIKENQPAKLTNEFVASLKIQNVETISQLEVYLENLTERENIERAKIDFQRNALTEIGEQVEVPLAKKLINLEIERLNEVFHSTLKQQEIPLKEYLKITKFTEKDIYDQFEVEAKKLLKNSFIFAEIAKLEGLVPTQQEYESHVEKLAKFTGKSVQEISETVSYNEIQINITNQKVIDKLIEFNHEAKDEEIVNKNQNDNEIEQDKEQKDNNEEKIKQENNLENK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: YBFA_BACSU
Sequence: MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILFEIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGKTIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFLSEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKHDEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKKFGFRISEVKQEAPLWGQQLTEERWDLELS
What is the function of this protein?
Putative DNA-binding acetyltransferase.
What are the official names of this protein?
Putative HTH-type DNA-binding domain-containing acetyltransferase YbfA.
Protein: PEPT1_DERPT
Sequence: MKIVLAIASLLALSAVYARPSSIKTFEEYKKAFNKSYATFEDEEAARKNFLESVKYVQSNGGAINHLSDLSLDEFKNRFLMSAEAFEHLKTQFDLNAETNACSINGNAPAEIDLRQMRTVTPIRMQGGCGSCWAFSGVAATESAYLAYRNQSLDLAEQELVDCASQHGCHGDTIPRGIEYIQHNGVVQESYYRYVAREQSCRRPNAQRFGISNYCQIYPPNVNKIREALAQTHSAIAVIIGIKDLDAFRHYDGRTIIQRDNGYQPNYHAVNIVGYSNAQGVDYWIVRNSWDTNWGDNGYGYFAANIDLMMIEEYPYVVIL
What is the function of this protein?
Thiol protease, with a preference for substrates with a large hydrophobic side chain in the P2 position, or with basic residues.
What are the official names of this protein?
Peptidase 1, Allergen Der p I, Major mite fecal allergen Der p 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GPR18_AMPAM
Sequence: MSGGEASITGRTAPELNASAAPLDDERELGETVAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLAVPAPPQRTSSRPLAELESVASQEDETEPSPEPEPLSSRADKPANGISVHQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGYVNSSLNPIIYTIYNKDFRTAFSRLLRCDRRMS
What is the function of this protein?
Probable G-protein coupled receptor for an amine.
What are the official names of this protein?
Probable G-protein coupled receptor No18.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RK32_SPIOL
Sequence: MAVPKKRTSIYKKRIRKNIWKKKGYWAALKAFSLAKSLSTGNSKSFFVRKISNQTLE
What is the function of this protein?
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
What are the official names of this protein?
50S ribosomal protein L32, chloroplastic, Chloroplastic large ribosomal subunit protein bL32c.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PYRG_DESVV
Sequence: MKTKFIFITGGVLSSLGKGLAAASVGALLKARGLKVTIQKLDPYINVDPGTMNPFQHGEVYVTDDGAETDLDLGHYERYLAEPMSQKNNYTSGSIYHRVITKERRGDYLGGTVQVIPHVTDEIKNAVLSLAEDDPDVALIEIGGTVGDIEGLPFLEAIRQLRGDLGKDRCLYIHLTLVPYLRAAGEHKTKPTQHSVKELRSIGIQPDIILCRCEEAITADLKRKIALFCNVDQDAVFSAVDVKNIYEVPLRFYEEGFDQKIAIMLRLPAKNPNLEPWETLVDTCAHPQGRVTIGIVGKYVDLKEAYKSLHEALVHGGVANKVAVDLKYVNSEEITEENVAEALKGLDGILVPGGFGYRGVEGKILTIRYARENRVPFFGICLGMQCAVIEFARNVMGLEDANSEEFNELSKNKVIYLMTEWFDHRRQAVERRDSSSDKGGTMRLGSYPCVVVPDTKAHDAYGVKHIDERHRHRFEFNKAYFDAMAQSGMVFSGLSPDGELVEIVELPDHPWFLGCQFHPEFKSNPMQPHPLFREFIRAAKTHPAGKR
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: CFA97_PONAB
Sequence: MDQFGDILEGEVDHSFFDSDFEEGKKCETNSVFDKQNDDPKERIDKDTKNVNSNTGMQTTENYLTEKGNERNVKFPPEHPVENDVTQTVSSFSLPASSRSKKLCDVTTGLKIHVSIPNRIPKIVKEGEGDYYTDGEESSDDGKKYHAKSKPAKPSTNVKKSIRKKYCKVSSSSSSSLSSSSSGSGTDCLDGGSDSHLSDSSPSSKKHVSGITLLSPKQKYKSGIKLTETQPSSTTPKCGHYPEESEDTVTDVSPLSTPDISPLQSFELGIANDQKVKVKKQENVSQEIYEDVEDLKNNSKYLKAAKKGKEKHEPDVSSKLSSVLDCSLDHRHKQKVLHDTMDLNHLLKAFLQLDKKGPQKHHFDQPSVAPGKNYSFTREEVRQIDRENQRLLKELSRQAEKPGSKSTIPRSADHPPKLYHSALSRQKEQQRIERENLALLKRLEAVKPTVGMKRSEQLMDYHRNMGYLNSSPLSRRARSTLGQYSPLRGASRTSSATSGLSCRSERSAVDPSSGHPRRRSKPPNVRTAWL
What are the official names of this protein?
Cilia- and flagella-associated protein 97.
What is the protein family that this protein belongs to?
Belongs to the CFAP97 family.
Protein: PTMA_ECO57
Sequence: MRLSDYFPESSISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSLTLLEQGVYFPGNDEPIKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASSEKQLADIISRG
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II CmtAB PTS system is involved in D-mannitol transport.
What are the official names of this protein?
Mannitol-specific cryptic phosphotransferase enzyme IIA component, EIIA, EIII, PTS system mannitol-specific EIIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBSAG_HBVB7
Sequence: MGGWSSKPRKGMGTNLSVPNPLGFFPDHQLDPAFKANSENPDWDLNPHKDNWPDAHKVGVGAFGPGFTPPHGGLLGWSPQAQGILTSVPAAPPPASTNRQSGRQPTPLSPPLRDTHPQAVQWNSTTFHQTLQDPRVRALYLPAGGSSSGTVSPAQNTVSAISSILSTTGDPVPNMENIASGLLGPLLVLQAGFFSLTKILTIPQSLDSWWTSLNFLGGTPVCLGQNSQSQISSHSPTCCPPICPGYRWMCLRRFIIFLCILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCKTCTTPAQGTSMFPSCCCTKPTDGNCTCIPIPSSWAFAKYLWEWASVRFSWLSLLVPFVQWFVGLSPTVWLSVIWMMWFWGPSLYNILSPFMPLLPIFLCLWVYM
What is the function of this protein?
The middle envelope protein plays an important role in the budding of the virion.  It is involved in the induction of budding in a nucleocapsid independent way.  In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
What are the official names of this protein?
Large envelope protein, L glycoprotein, L-HBsAg, LHB, Large S protein, Large surface protein, Major surface antigen.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus major surface antigen family.
What are the subcellular locations of this protein?
Virion membrane.
Protein: YD177_YEAST
Sequence: MSKNVGKLVKIWNESEVLVDRKSKFQARCCPLQNQKDIPSILQELTQNNKSVSKASHMHMYAWRTAEVSNNLHLQQEQKKKGNKANKSNNSHVNKSRNITVQPKNIEQGCADCGEAGAGQRLLTLLERANIFNVLVIVTRWYGGTPLGSSRFRHISTCAVETLKKGGFLP
What are the official names of this protein?
IMPACT family member YDL177C.
What is the protein family that this protein belongs to?
Belongs to the IMPACT family.
Protein: GPX2_SAPAP
Sequence: MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPHDDPFSLMTDPKFIIWSPVCRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI
What is the function of this protein?
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides.  Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
What are the official names of this protein?
Glutathione peroxidase 2, GPx-2, GSHPx-2, Glutathione peroxidase-gastrointestinal, GPx-GI, GSHPx-GI.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MCRX_METFV
Sequence: MNKKNKKLFLEALEKKFKGESPEEKKTTFYCFGGWKQSERKREFVEYAKKLAKKRGIPFYNPDIGVPLGQRKLMAYRISGTDAYVEGDDLHFVNNAAIQQMVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPGLVDDCYAKIFTGNDELADELDKRVLIDINKEFPEEQAEMLKKYIGNRTYQVNRVPTIVVRCCDGGTVSRWSAMQIGMSFISAYKLCAGEAAIADFSFAAKHADVIEMGTILPARRARGPNEPGGIPFGVFADIIQTSRVSDDPARISLEVIGAAATLYDQVWLGSYMSGGVGFTQYASATYTDDILDDFVYYGAEYVEDKYGFCGVKPSMEVVKDIATEVTLYGLEQYEEYPTLLEDHFGGSQRAAVVAAAAGCSTAFATGNSNAGINAWYLSQILHKEGHSRLGFYGYDLQDQCGASNSLSIRSDEGLVHELRGPNYPNYAMNVGHQPEYAGIAQAPHAARGDAFVVNPLIKVAFADNDLSFDFRWPRKEIARGALREFMPDGERTLIIPASK
What is the function of this protein?
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB).  This is the final step in methanogenesis.
What are the official names of this protein?
Methyl-coenzyme M reductase II subunit alpha, MCR II alpha, Coenzyme-B sulfoethylthiotransferase alpha.
What is the protein family that this protein belongs to?
Belongs to the methyl-coenzyme M reductase alpha subunit family.
Protein: COAX_LISMC
Sequence: MILVIDVGNTNCTVGVYEKQKLLKHWRMTTDRHRTSDELGMTVLNFFSYANLTPSDIQGIIISSVVPPIMHAMETMCVRYFNIRPLIVGPGIKTGLNLKVDNPREIGSDRIVNAVAASEEYGTPVIVVDFGTATTFCYIDESGVYQGGAIAPGIMISTEALYNRAAKLPRVDIAESNQIIGKSTVASMQAGIFYGFVGQCEGIIAEIKKQSNASPVVVATGGLARMITEKSSAVDILDPFLTLKGLELLYRRNKPTTEK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LST8_DROPS
Sequence: MGDQLILATGGYDHTIKVWQAHTGNCIKTMRFVETSQVNALDRTPDKTRLAACGYQCIRLYDLESNCTAPVINFDGVQKNVTRLGFQEDGNWMFTAGEDHHVRIWDMISAPPHCSRVFDCESPVNAACLHPNQVEIGMGSQNGNVFLWDVKSEKHECIVPEVDASIQDVAISPDGHYLAAANNKGNCYIWSLCSSPDQKMSTMRPTKKIQAHTRYILRCKFSPDSRLLLTTSGDGTACLWKTSDFSKWRELCIENYWVWDAAFSADSKWLFTASSDGVARLWKLETKTPTREYTGHTKAITALSFKDEIIRKVNH
What are the official names of this protein?
Protein LST8 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LST8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIMA_PORGI
Sequence: MKKTKFFLLGLAALAMTACNKDNEAEPVVETNATVSFIIKSGESRAVGDDLTDAKITKLTAMVYAGQVQEGIKTVEEDGGVLKVEGIPCKSGANRVLVVVANHNYELTGKSLNEVEALTTSLTAENQNAKNLIMTGKSAAFTIKPGSNHYGYPGGTASDNLVSAGTPLAVTRVHAGISFAGVEVNMATQYQNYYSFKPADAKIAALVAKKDSKIFGNSLVSNTNAYLYGVQTPAGLYTPDAAGETYELEASLNTNYAVGAGFYVLESKYDASNELRPTILCIYGKLLDKDGNPLTEPALTDAINAGFCDGDGTTYYPVLVNYDGNGYIYSGAITQGQNKIVRNNHYKISLNITGPGTNTPENPQPVQANLNVTCQVTPWVVVNQAATW
What is the function of this protein?
Structural subunit of the major fimbriae (PubMed:27062925).  These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome.  They play an important role in the invasion of periodontal tissues.  Fimbriae and their constituents are major virulence factors.  FimA proteins from different strains have highly divergent sequences, and this has been used for classification.  The sequence-based classification correlates with pathogenicity.
What are the official names of this protein?
Major fimbrium subunit FimA type-4, Fimbrillin, Fimbrilin, Major fimbrial subunit protein type-4, FimA4.
What is the protein family that this protein belongs to?
Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.
What are the subcellular locations of this protein?
Fimbrium. Cell outer membrane. Note=Synthesized as palmitoylated precursor. The lipidated propeptide is removed during processing to the mature protein.
Protein: NU4LM_EPIFU
Sequence: MSLVHMNIGLAFTVAFLGLLMYRSHLMSSLLCLEGMMLTLFIMSSIMVLNMHFTLASMLPIILLVFAACEAAVGLSLLVMVSNTYGVDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PUR9_MOUSE
Sequence: MAPSQLALFSVSDKTGLVEFARSLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLVRVVVCNLYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYAGVAAEMHGSDSKDTSLETRRHLALKAFTHTAQYDEAISDYFRKQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLAVAYARARGADRMSSFGDFVALSDICDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVATVAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEISNAIDQYVTGTIGEGEDLVKWEALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH
What is the function of this protein?
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:29072452).  Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:29072452).  Also displays cyclohydrolase activity involving the cyclization of FAICAR to IMP.  Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction.  Also catalyzes the cyclization of FAICAR to IMP.  Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity).
What are the official names of this protein?
Bifunctional purine biosynthesis protein ATIC, AICAR transformylase/inosine monophosphate cyclohydrolase, ATIC.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: LSPA_RICAH
Sequence: MCLLIKKLYLTFARSTSIIITLVIIDQLSKWWFIDNLRWTPGLMLKVTSFLNMVYTWNYGISFGLMREYYQYSNAIFLITNTLIVCYLYYLMIRSNTIGSFAGYSFVIGGAVGNLIDRCFRGAVFDFIHFHYHNYSFPVFNLADCFITIGVIILIEDYDNTKKVIEEKIKGNYDNAQIEAMAEKIRNTDQGGNDKV
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.