PharMolix/UniProtQA huggingface dataset:
Protein: EFTS_CLOD6
Sequence: MANITAQMVKELRESTGAGMMDCKKALQEAEGNMEKAVDLLREKGLSKAAKKAGRVAAEGLVAIEMNDDNTVASMVEVNSETDFVAKNEDFKVFVKDAACMALATDKEDIASLLGETHKEGITLQEVLNNRVAKIGEKLDFRRFAKVVTNGQVAGYIHGGGKIGVLVEMETEARDAKVLELGKDVAMQVAAMNPKYVSRDEVDAEYIAHETEVLTQQALNEGKPANIVEKMVKGRLEKELKEVCLLEQTFVKNPDITVKQLVADVAKAVGSDIKVVKVVRFEVGEGIQKREENFAEEVAKQLK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFR_STAAU
Sequence: MNFNNKTKYGKIQEFLRSNNEPDYRIKQITNAIFKQRISRFEDMKVLPKLLREDLINNFGETVLNIKLLAEQNSEQVTKVLFEVSKNERVETVNMKYKAGWESFCISSQCGCNFGCKFCATGDIGLKKNLTVDEITDQVLYFHLLGHQIDSISFMGMGEALANRQVFDALDSFTDPNLFALSPRRLSISTIGIIPSIKKITQEYPQVNLTFSLHSPYSEERSKLMPINDRYPIDEVMNILDEHIRLTSRKVYIAYIMLPGVNDSLEHANEVVSLLKSRYKSGKLYHVNLIRYNPTISAPEMYGEANEGQVEAFYKVLKSAGIHVTIRSQFGIDIDAACGQLYGNYQNSQ
What is the function of this protein?
Specifically methylates position 8 of adenine 2503 in 23S rRNA.  Confers resistance to some classes of antibiotics, such as chloramphenicol, florfenicol, clindamycin and linezolid.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase Cfr, 23S rRNA (adenine(2503)-C(8))-methyltransferase, 23S rRNA m8A2503 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARND_SALPB
Sequence: MTKVGLRIDVDTLRGTREGVPRLLATLHRHGVQASFFFSVGPDNMGRHLWRLIKPRFLWKMLRSNAASLYGWDILLAGTAWPGKNIGNANAGIIRETATYHETGLHAWDHHAWQTHSGHWSIRQLEEDIARGITALEAIIGKPVTCSAAAGWRADGRVVRAKEPFNLRYNSDCRGTTLFRPLLMPGQTGTPQIPVTLPTWDEVIGPAVQAQSFNTWIISRMLQDKGTPVYTIHAEVEGIVHQPLFEDLLVRARDAGITFCPLGELLPASPESLPLGQIVRGHIPGREGWLGCQQAASAS
What is the function of this protein?
Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.
Protein: EUTS_ECOLI
Sequence: MDKERIIQEFVPGKQVTLAHLIAHPGEELAKKIGVPDAGAIGIMTLTPGETAMIAGDLALKAADVHIGFLDRFSGALVIYGSVGAVEEALSQTVSGLGRLLNYTLCEMTKS
What is the function of this protein?
A component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation.  Its unusual hexameric shape may help form the BMC shell (Probable).  Targets at least 2 proteins (EutC and EutE) to the interior of the BMC (By similarity).  Proteins such as EutS containing circularly permuted BMC domains may play a key role in conferring heterogeneity and flexibility in this BMC (Probable).
What are the official names of this protein?
Bacterial microcompartment shell protein EutS, Ethanolamine utilization protein EutS.
What is the protein family that this protein belongs to?
Belongs to the EutS/PduU family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: CYPH_CATRO
Sequence: MPNPRVFFDMSVGGQPAGRIVMELFADTTPRTAENFRALCTGEKGTGRSGKPLHYKDSSFHRVIPGFMCQGGDFTAGNGTGGESIYGAKFADENFIKKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGQVVEGMDVVKAIEKVGSSSGRTAKKVVVEDCGQLS
What is the function of this protein?
PPIases accelerate the folding of proteins (By similarity).  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:24939849).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase, PPIase, Cyclophilin, Cyp, Cyclosporin A-binding protein, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_PROM9
Sequence: MRQHVNPLSRNFNEIERIPALIEMFGDSKSNLHLDIGCAAGEFLFDLALINTNWNYIGIEIRERLVKTAKLKVRERDIKNLYFIFGNANNILHDVQSKFIFKNVKSISFNFPDPWFKKRHYKRRVIQPEFLNLLSNSLQKGSLIFIKTDVKDLFDYMDCIISNNFNFKKIDKNDFNFSESFNPSQVKTNREKYVIVNQLDIFERIYIKI
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: HIS6_BACAH
Sequence: MLAKRIIPCLDVKEGRVVKGVNFIGLQDVGDPVEIAALYNDAGADEIVFLDITATHEGRKTIIDVVKKTASKVFIPLTVGGGISSVKDMYKLLRAGADKVSINSAAVRNPKLIEEGAQHFGSQCIVVAIDARKVAEGKWNVYVNGGRVDTGMDAIEWAKRVVMLGAGEILLTSMDADGTKNGYDLRLTEEISKSVSVPVIASGGCGHADHIIEVFQKTTVDAALAASIFHYGEATVQDVKRKLRNANVEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLA1_PIG
Sequence: MASVSELACIYSALILHDDEVTVPEDKINALIKAAGVNVEPFWPGFFAKALANVNIGSLICNVGAGGPPPPAGAAPPGGPAPPPPAAPAEEKKVEAKKEEFEESDDDMGFGFFD
What is the function of this protein?
Plays an important role in the elongation step of protein synthesis.
What are the official names of this protein?
60S acidic ribosomal protein P1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Protein: CAH4_RABIT
Sequence: MQLLFALLALGALRPLAGEELHWCYEIQASNYSCLGPDKWQEDCQKSRQSPINIVTTKAEVDHSLGRFHFSGYDQREARLVENNGHSVMVSLGDEISISGGGLPARYRATQLHLHWSQELDRGSEHSLDGERSAMEMHIVHQKETGTSGNEVQDSDDSIAVLAFLVEAGPTMNEGFQPLVTALSAISIPGTNTTMAPSSLWDLLPAEEELRHYFRYMGSLTTPACSETVVWTVFQEPIRLHRDQILEFSSKLYYDQERKMNMKDNVRPLQRLGDRSVFKSQAAGQLLPLPLPTLLVPTLACVMAGLLR
What is the function of this protein?
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH.  May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis.  It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
What are the official names of this protein?
Carbonic anhydrase 4, Carbonate dehydratase IV, Carbonic anhydrase IV, CA-IV.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: XYLA_HAEI8
Sequence: MTTYFDKIEKISFEGEKSTNPFAFKHYDANQVILGKTMAEHLRLAVCYWHTFCWNGNDMFGLGSLERSWQKNPNVLAGAEQKADIAFEFLNKLGVPYYCFHDVDIAPEGNSVREYVQNFHHIVDILERKQVETGVKLLWGTANCFTNPRYMSGAATNPNPEVFAWAATQVFNAMNATQRLGGENYVLWGGREGYETLLNTDLKREREQIGRFMQMVVEHKHKIGFKGTLLIEPKPQEPTKHQYDYDVATVYGFLKQFGLEKEIKVNIEANHATLAGHTFQHEIATACALDIFGSIDANRGDPQLGWDTDQFPNSVEENTLVMYEILKHGGFTTGGFNFDAKIRRQSIDPYDLFYAHIGAIDVLALSLKRAAKMLQEKTLQKIVNARYAGWNSELGQHILQGKTSLETLAQLVQQKDLAPKPVSGQQEYLENLVNQVIYS
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF3_LACSA
Sequence: MPRSRINGNFIDKTFSIVANILLRIIPTTSGEKEAFTYYRDGMSAQSEGNYAEALQNYYEAMRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFRALERNPFLPQAFNNMAVICHYRGEQAIRQGDSEIAEAWFDQAAEYWKQAIALTPGNYIEAHNWLKITRRFE
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: TODB_PSEP1
Sequence: MTWTYILRQGDLPPGEMQRYEGGPEPVMVCNVDGEFFAVQDTCTHGDWALSDGYLDGDIVECTLHFGKFCVRTGKVKALPACKPIKVFPIKVEGDEVHVDLDNGELK
What is the function of this protein?
This protein seems to be a 2Fe-2S ferredoxin.
What are the official names of this protein?
Toluene 1,2-dioxygenase system ferredoxin subunit.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin component family.
Protein: ADH1_TRIRP
Sequence: MSNTAGQVIKCRAAVAWEAGKPLVIEEVEVAPPQAGEVRLKILFTSLCHTDVYFWEAKGQTPLFPRIFGHEAGGIVESVGEGVTHLKPGDHALPVFTGECGECPHCKSEESNMCNLLRINTDRGVMINDNKSRFSIKGQPVHHFVGTSTFSEYTVVHAGCVAKINPDAPLDKVCILSCGICTGLGATVNVAKPKPGSSVAIFGLGAVGLAAAEGARMSGASRIIGVDLVSSRFELAKKFGVNEFVNPKDHDKPVQQVIAEMTDGGVDRAVECTGSIQAMISAFECVHDGWGVAVLVGVPKKDDAFKTHPMNFLNERTLKGTFYGNYKPRTDLPNVVEQYMKGELELEKFITHSIPFSEINKAFDYMLKGESIRCIIRMEE
What are the official names of this protein?
Alcohol dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_RHOP5
Sequence: MSPRVVVTGTDTGIGKTVFSAALVGALDGVYWKPVQAGLDEETDRDTVLRLSGLPAERMLPEAYRLNTPASPHLAAEIDGVTIDPAKLALPQHDRPLVVEGAGGLLTPLTRSVSYIDVIASWHAPVVLCARTTLGTINHSLLSIEALRARDIELLGIAFIGEAHAESENIIAAMGQVRRLGRLPHLASLTTDSLKAAFADAFNIGDFFKDATA
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPT_BURCH
Sequence: MTHPTELPLSPLSALQFYATAPYPCSYLDGRIARSQVATPSHLINSDIYTELVKAGFRRSGVFTYRPYCDGCRACVPVRVPVGEFAPTRTQRRMWKRHRALVATVSPLHYDEEHYALYMRYQSARHAGGGMDRDSRDQYEQFLLQSRINSRLVEFRDLDAPGGEPGKLRMVSMIDILGDGLSSVYTFFEPDDRHTSYGTYNILWQIEQAKSLGLPYVYLGYWIRESPKMAYKANFHPLEGLIDGRWKTLDPERIDLPPVDAALARAPLPGGHSGSG
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_BUCAT
Sequence: MFDSNHEQELSKRRTFAIISHPDAGKTTITEKMLFFGKVIRVPGTIKGRGSGKYAKSDWMNIEKERGISITTSVMQFTYKNILMNLLDTPGHQDFSEDTYRILTAVDCCLVVIDAAKGIEERTRKLMDVARIHNTPIITFINKLDRDSRDPIEILDEIEKELKLHCIPISWPISCGKNFRGVYHIHDKIIHLYKSKFRKNFLTLDSFLDGSLNEYLGADLSIYIRQELELIMNVYSKFNKEKFLKGITTPIFFGSALGNFGIDHLLDSLIKWAPSPLYRQSNKRIIKPQERNFTGFIFKIQANMDLKHRDRIAFMRIVSGQYTKGMKLTHVRIKKNIIISDAFSFLAGERISINKAYPGDVIGLHNHGTIKIGDTFTQGEEIKFIGIPSFAPEIFRLIYLKNPLKQKQLKKGLVQLSEEGTVQVFRPILNNDLILGAIGILQFDVVIERLRIEYNIDAVYKKVNIVLARWINCGNHHSLYNLKKSYSSYLAYDISNSLIYLAPSSANLNIVMSQNSDISFNATREQ
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FB123_ARATH
Sequence: MSRTRYDWSKLCHDILRLILESLHYKDYHRARTVCSNWYTASTTCKRPLYPWRIKFNKISTSLFDPREDKIHEIQHPGIEFSDRNVLASCSNWFLMVDSGLEFYLLNAFTRERINLPSMESSILGKERLEKEVAWKHFIERTDIISTKKQACLWINERTGDYVVAWSIKQHYLFTYKKGDDSWLNLEGTKCVSMALNKDYKLYVYALDNSIKIFDLYGEFPSEIVEENPYRNHPFSFRFVSKPEEHAWKQVVAITNSGEVLMIVSLKGLEDKRLFYIYKMDFGSCNWERVDSLGGEMLIFGHGVTIRAPILDINGLGIKSDSICFRGDDLWPLSQLFIPITQPMCGVFDLATSTITWPKSLDASVLKSFWFVPGHA
What are the official names of this protein?
Putative F-box protein At2g33200.
Protein: PSBZ_CYAM1
Sequence: MSIILQILVVALIVYSFVLIVAVPITLSTASGWSKSKSSIVTASIGWVGMVLLTGVLNSFVS
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: RS8_CLOAB
Sequence: MVMTDPIADLLTRIRNANVVRHGVVELPSSKIKKAMANILLQEGYLKDIEEYNDGVVPMLRLSMKYGKGKERIVTGLKRISKPGLRVYCRKEEIPKVLNGLGIAIISTSKGIVTDKEARKLGLGGEVLCYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SLB_BOTAS
Sequence: DCPSDWSSYEGHCYRVFKPPKDWADAERFCSQQAKGGHLVSIERFGREDFVSNLITKNLQRG
What is the function of this protein?
Snaclec that binds to von Willebrand factor (VWF) and induces its interaction with GPIbalpha (GP1BA) (via the vWF A1 domain), resulting in platelet aggregation.  Intramuscular and intravenous injections in mice induce a dose-dependent drop in platelet count (thrombocytopenia).  Pretreatment by intravenous injection by this protein in mice potentiates the hemorrhagic lesion in the skin provoked by the metalloproteinase BaP1 intradermally injected.  This result is not observed when both BaP1 and this protein are injected simultaneously.
What are the official names of this protein?
Snaclec aspercetin subunit beta.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2073_STAES
Sequence: MNQMNQTIIDAFHFRHATKEFDPTKKISDEDFNTILETGRLSPSSLGLEPWHFVVVQNKELREKLKAYSWGAQKQLDTASHFVLIFARKNVTAHTDYVQHLLRGVKKYEESTIPAFENKFDDFQESFHIADNERTLYDWASKQTYIALANMMTSAALLGIDSCPIEGFDLDKVTEILSDEGVLDTEQFGISVMVGFGYRAQEPKHGKVRQNEDDIISWIE
What are the official names of this protein?
Putative NAD(P)H nitroreductase SE_2073.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family.
Protein: PYRH_JANSC
Sequence: MPNDVTPGHPAGDDAKYARVMLKISGEALMGDQGFGLHPPTVERIAREIQSVHDMGVEICLVIGGGNIFRGLQGSAQGMERTTADYMGMLATVMNALAMQGALESLGVYTRVISAITMNEVAEPYIRRRAIRHLEKKRVCIFAAGTGNPYFTTDTAATLRASEMDCEAIFKGTKVDGVYDKDPAKHADAKRYETVTYDEVLAQHLGVMDASAIALARENKLPIMVFSLDEPGGFRSILDGTGTYTKVVE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCN8A_MOUSE
Sequence: MAARVLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEDGVGSPRSSSELSKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGPGSHIGRLLPEATTEVEIKKKGPGSLLVSMEQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELGLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISQECKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWAKVKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGVDIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIDEVNNKTDCEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICRKITSNKLENGGTHREKKESTPSTASLPSYDSVTKPDKEKQQRAEEGRRERAKRQKEVRESKC
What is the function of this protein?
Mediates the voltage-dependent sodium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.  In macrophages, isoform 5 may participate in the control of podosome and invadopodia formation.
What are the official names of this protein?
Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Note=Mainly localizes to the axon initial segment.
Protein: MSRA_HALS3
Sequence: MGTETATLGGGCFWCTEAAMEELAGVTDVTSGYAGGDTADPSYRDVCSGTTGHAEVVQVEYDTAELAYEDVLEVFFTVHDPTTVDREGPDVGSQYRSIVLPHDDQQHERATAFVDELAAADAFDGSIVTEIEPLETFYPAAEKHQNYFEKNPDAAYCTVNVAPKVSKVREQFGARTE
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: AMPA_VIBCM
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPVAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHQVPGVLSERVLLVGCGKERELGERQYKEIIQKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVEATKDGLYIFDQFKSVKPEIRRPLRKLVFNVPTRRELNLGERAITHGLAISSGVKACKDLGNMPPNIANPAYLASQARRLADDYESITTKIIGEEEMEKLGMASYLAVGRGSRNESMMSVIEYKGNPDPEAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGAASVFGTMKAIAKLGLPLNVIGVLAGCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPECVVDVATLTGACVIALGHHISAVMSNHNPLAHELVNASEQSSDRAWRLPLADEYHEQLKSPFADMANIGGRPGGAITAACFLSKFAKKYNWAHLDIAGTAWKSGAAKGSTGRPVSLLVQFLLNRSGGLDAEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_SHESH
Sequence: MKQLRLEPINKVQGTINIPGSKSISNRALLLATLAKGTTTLTNLLDSDDIRYMLASLKQLGVNYRLSNDNTVCELEGIGAPLNSEQAQTLFLGNAGTAMRPLCAALTLGHGEFTLTGEPRMEERPIGDLVDALRQLGANVTYLKNDGFPPLTINATGLDAGEVEIAGDLSSQFLTALLMVAPLATGDVNIKIKGELVSKPYIDITIALMAQFGVQVVNHSYERFEIKAGQGYVSPGKVLVEGDASSASYFLAAGAIKGGEVKVTGVGRMSIQGDVKFADVLEKMGADIEWGDDYIISRGSTLKAVDLDMNHIPDAAMTIATAALFATGTTHIRNIYNWRIKETDRLAAMATELRKVGAIVDEGHDYISITPPTKPHTADIDTYNDHRMAMCFSMLAFADCGITINDPDCTSKTFPDYFNQFAALAQ
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGFR2_PIG
Sequence: MGRGLLGGLWPLHVVLWTRIASTIPPHVPKSVNSDMMVTDSNGAVKLPQLCKFCDVRSSTCDNQKSCLSNCSITAICEKPQEVCVAVWRKNDENITIETVCDDPKIAYHGFVLDDAASSKCIMKERKGSGETFFMCSCSSDECNDHIIFSEEYATNNPDLLLVIFQVTGVSLLPPLGIAIAVIITFYCYRVHRQQKLSPSWDSGKPRKLMEFSEHLAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLRQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDL
What is the function of this protein?
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.  Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.  The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2.  Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4.  The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes.  This constitutes the canonical SMAD-dependent TGF-beta signaling cascade.  Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).
What are the official names of this protein?
TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane raft.