Protein: SQTKS_PHOSC
Sequence: MVPYYQPASSCGSNTMAAMDEHQHNEDATIPIAIIGMSCRFPGNATSPEKLWELCAQGRSAWSSIPKSRFRQEGFYNPNAERVGTSHVVGGHFLEEDPSLFDASFFNLSAEAAKTMDPQFRLQLESVYEAMESAGITLEHIAGSDTSVYAGACFRDYHDSLVRDPDLVPRFLLTGNGAAMSSNRVSHFYDLRGASMTVDTGCSTTLTALHLACQGLRNRESKTSIVTGANVILNPDMFVTMSSLGLLGPEGKSHTFDARANGYGRGEGIATVIIKRLDDALRAQDPIRCIIRGTALNQDGRTATLTSPSQTAQSDLIRACYRAAALDPNDTAFLAAHGTGTRTGDAVEIAAAADVFGEKRSPERPLWIGSVKTNIGHSEATSGLASVIQAALALEKGLIPPNINFKEPNEKLGQVSAAVRVPSNLQKWPSVSGVRRASVNNFGYGGANAHVILESGIPGHTPIANGSGRSNGTGNGHNGANGTTNGHNGTNGTTNGHFDATQATNGHYGTDETPDYAPLDSFVISISAKEEASARSMVTNLADYLRTLQVQDETKHFKSIAHTLGSHRSMFKWTAAKSITGPEELIAAAEGGQFQASRALERTRLGFVFTGQGAQWFAMGRELINTYPVFRQSLDRADRYLKEFGCEWSIIDELSRDAENSNVNDMTLSPPLCTAVQISLVQLLESWGIVPTAVTGHSSGEIAAAYAAGALDFKSAMAVTYFRGEVGLACQDKIVGKGGMIAVGLGPEDAEDRIARVQSGKIVVACINSQSSVTVSGDLSGIVELEDLLKAEGVFARRVKVQAAYHSHHMQVIANGYLTSLKDMLKPTKKFGKIIYSSPTTGRRETNAKLMASAQHWVNNMLSPVRFAESFQNMCFSNRNSSQSEEIFQDVDIVLEVGPHGMLQGPIQQMMSLPIFERARLPYISCLLRGQSAVHTMQTVAAGLMGWGYRVDMVAVNFPQGTYGVKILHDLPSYPWNHDNSHWWEPRLNKAHRQRVHPPHDLLGSLIVGRDLREPTWRHFIRVQDIPWIRDHVVQSALVYPGAGFICMAMEAMVQLHELRDSQSRKVAGYRLAEVDILRAMLIPDTSEGLEAHISLRPCSTKLLLTNEWYDFCVSSVGDDDKFVDHCRGRITIEFDTSGSADTPRTSLRERSRSTGLMRSVDPSNLYSFLRAQGIYHGPIFQNLKTISSRKDHSESSFVVANTASVMPNGFQSPHVIHPTTLDSIFQGAYTALPGAGLDQNTAMIPRSIQELYLSSALTSDVGQCLVSDTSLIRYDGQSFTVNVDVSSKADSEHTPVLEIKGLRNQSVGQMAPQPGDSSNNDLCFKLDWAPDISSVKQERLKEKFGFPLDPTEADIIMGLRQACIHFIHRSLQSLTAPDRDQLDWHQKRFYDWMVLQIQLAEEDRLAPNSSAWLQCSSSDEQKLLENVRASSVNGQMVVHVGKSMLAILRHEIAPLELMLQDKLLYRYYTDAIKWDRSYQQIDQLVKLHAHKCPTAKIIEIGAGTGGCTRAVLDALSNQGIARCAQYDFTDVSSGFFEAAQQKFAAFDDVIRFQKLDIEKDIEMQGFECGSYDLVIASQVLHATGKMEHTMANVRKLLKPGGKLLLVETTRDEMDLQLVFGLLPGWWLSSEEERQMSPSLSTNSWEKVLKKTGFDGLDIELRDCDSDEFYSFSVMMATASSTIASSSMAFAIVYGEVPLPDQFLDDMKTAISSSAVSDPVVGHLDSIDATGKFCIFIEDPETDILSSPDEKSYASIQKLVTRCKGLIWVSRGGAMHGTRPNSSLKTGLLRTLRLEYTEKRFISLDLDSARPQWNHDSITTINEVLCGALAQNADSSIKDSEFAEQDGQLFVPRISCDIARNEDLSSDSNSPAQMEPFHQPGKLLQMGIKTPGLIDTLQFSKTDATDNLPNDYIEIEPKAFGLNFRDVMVAMGQLEESIMGFECAGVVRRVGPSSAGHNIKVGDRVCALLGGQWTNTVRVHWHSVAPIPQAMDWETAASIPIVFVTAYISLVKIARMQAGETVLIHAASGGVGQAAIILAKHVGAEIFATVGTDEKRDLLIKEYKIPDDHIFSSRNALFAKSIRQRTNGKGVDVVLNCLAGGLLQESFDCLADFGRFIEIGKRDIELNHCLNMGMFARSATFTAVDLIAIGRDRSYMFAEALPKIMTLLQEKAIRPVTPISIYKIGDIETAFRLMQAGKHMGKIVITAPEDAMVPVITRPPKLQLRPDASYLIVGGLGGIGRSLCKNFVENGARSLVLLSRNANVSQQSGEFLDELRSTGCIVGVVDCDISSKTQVEATMLRLKKDMLPIRGIVHAGMVLQDSVFERMSLDDYNTAIRPKVQGSWNLHSGLSDCDLDFFIMLSSLAGVSGSASQANYTAGGAYQDALAKYRRAQGLSAVSIDLGMVQSVGYVAETKGVAERLVRMGYSPISEMEVLKIVEHAITNPPPEASSAQIITGISTKPGRHWTESSWLQDARFATLRERARDVKELSNSQGGAQDKQLAAGQELSMATSLVEAIDVVGRAITAKLATMFLIAAESIIASKSLSEYGVDSLVAVELRNWLAAQLSSDVSVFDVTQSQSLTALATTVATKSSRIDKSLLVA
What is the function of this protein?
Highly reducing polyketide synthase (HR-PKS); part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a lead compound for the treatment of hyper-cholesterolemia by targeting squalene synthase (SS) (PubMed:15489970).  Pks1 is responsible for the biosynthesis of the tetraketide sidechain of SQS1 (PubMed:15489970).  The biosynthesis must involve 3 rounds of chain extension.  After the first and second rounds methyl-transfer occurs, and in all rounds of extension the ketoreductase and dehydratase are active.  The enoyl reductase and C-MeT are not active in the final round of extension (PubMed:15489970).
What are the official names of this protein?
Squalestatin tetraketide synthase, SQTKS, Highly reducing polyketide synthase 1, HR-PKS 1, Squalestatin S1 biosynthesis cluster protein pks1.