PharMolix/UniProtQA huggingface dataset:
Protein: ADT2_SOLTU
Sequence: ADNQHPTVYQKVASQMHLSSSLSQDVHARYGGIQRPALSQRRFPYGNYSNAGLQTCQATQDLSLIAANASPVFVQAPQEKGLAAFATDFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMIKAGRLSEPYKGIGDCFSRTIKDEGFAALWRGNTANVIRYFPTQALNFAFKDYFKRLFNFKKDRDGYWKWFAGNLASGGGAGASSLLFVYSLDYARTRLANDAKAAKKGGGGRQFDGLVDVYRKTLKSDGVAGLYRGFNISCVGIIVYRGLYFGMYDSLKPVLLTGKMEDSFFASFALGWLITNGAGLASYPIDTVRRRMMMTSGEAVKYKSSFDAFNQILKNEGPKSLFKGAGANVLRAVAGAGVLAGYDKLQVIVFGKKYGSGGG
What is the function of this protein?
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).  Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
What are the official names of this protein?
ADP,ATP carrier protein, mitochondrial, ADP/ATP translocase, Adenine nucleotide translocator, ANT.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UPPP_CAMJJ
Sequence: MENLYALILGIIEGLTEFLPISSTGHMILGTTILGIDIDEFWKSFLIIIQLGSILAVIFVFWRKLFQGLDIWLKLAVGFFPTGVIGLFVAKYLNALFNGWVVVGMLIFGGVVFILIELAHKNKQYRINSLEEISFKQAFCIGIFQSLAMIPGTSRSGASIIGGLLLGFNRKVAAEFSFLLAIPTMIIATAYSIYKEPELLSNANSLIPLGIGFITAFIVAVLVIKFFLKFISKFDFIPFGIYRIILGFVFFYLYYSGILNAGSEFKL
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASSY_LISMH
Sequence: MAKEKIVLAYSGGLDTSVAIQWLVESGYEVIACCLDVGEGKNLDFIKEKAITVGASESYTIDAKEEFAEDFALIALQAHAYYEGKYPLISALSRPLIAKKLVEVARQEGASAIAHGCTGKGNDQVRFEVAIHALAPDLKVVSPVRDWKWSREEEINYAKEHNIPVPIDLDNPFSIDQNLWGRSNECGVLENPWTTPPEAAYDLTVSLEDAPDTPDIVEITFDAGIPISLNGENMSLANLILTLNEIAGKHGVGRIDHIENRLVGIKSREVYECPAAVTLITAHKELEDLTFVREVAHFKPIIEQKISETIYNGLWFSPLTEALVAFLKSTQKFVNGTIRVKLFKGHAIVEGRKSPNSLYDENLATYTSSDTFDQDAAVGFIKLWGLPTKVSAEVNSKVTITTEV
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAL1_SCHPO
Sequence: MADEIMENVELTTSEDVNAVSSFEEMNLKEDLLRGIYAYGYETPSAVQSRAIIQICKGRDVIAQAQSGTGKTATFSIGILQSIDLSVRDTQALILSPTRELAVQIQNVVLALGDHMNVQCHACIGGTSVGNDIKKLDYGQHVVSGTPGRVTDMIRRRNLRTRNVKMLILDEADELLNQGFKEQIYDIYRYLPPGTQVVVVSATLPQDVLEMTNKFTTNPVRILVKRDELTLEGLKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNSRRKVDWLTEKMREANFTVTSMHGEMPQKERDAIMQDFRQGNSRVLICTDIWARGIDVQQVSLVINYDLPANRENYIHRIGRSGRFGRKGVAINFVTNEDVRILRDIEQYYSTVIDEMPMNIGDMV
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase fal1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TIG_ACICJ
Sequence: MQVTETLTEGLKRGFTVVVPGSDLSEKREKRLAELSKTMQMPGFRPGKVPLSMVRKRFGDAVAAEVMEASVNEATERMINDRSLRPAVQPKVEVVRAEPDSDLEFTVELEVLPEVTIPDLKAISLTRPKAPVTEAEIDEAIARFAEQRAETEVVTEDRPAATGDILTVDFLGKRDGVPFEGGAGTDTDIELGGSGFIPGFAEQMEGMKAGETKVITVTFPEQYHAAELAGKEATFDITAKALKRRVAPVIDDAFAEANGFENLAEFRKFFADRLEQSRAGASRLKVKRALLDKLAEQADFPAPASLVDAEFAEIWRQVEAEKQAGRLDEEDAGKDEETLRADYRAIAERRVRLGLLVAEIGRTNNVQITEQDMRRAMIAEMQQFPGQEKMIMEFYQKNPRALDRLRGPIFEDKVVDYALELATVTDEEVSAEALFADTDD
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: HPCL1_TAEGU
Sequence: MGKQNSKLRPEVLQDLRENTEFTDHELQEWYKGFLKDCPTGHLTVEEFKKIYANFFPYGDASKFAEHVFRTFDTNGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRGEMLEIVQAIYKMVSSVMKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIKGAKSDPSIVRLLQCDPSSASQF
What are the official names of this protein?
Hippocalcin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
Protein: IWS1A_XENLA
Sequence: MEADNYSPEHSDDGGATPVQDERDSASDDEGNEQRSEPGSPEHQSEDEHSDVEDHKHSSDSGSDNEKGTEHDSEDEHRPRNSSDLENHDASDSENEESHNRIASDSEDDGRRQKNSDSDRSPVKGAASDSDEEPVRHSASDSEDDVPRKQQANDSEDERHIKKTASDSEDEAPAKHRVSDTEDKAPPKQVASDSEDEASPKQVASDSKDEAPPKHAASDSEDEAPPKLAGSDSEDEAPAKRKVSSSEDETPSKHAVSASKVKKSVGSEDKTRGKRAIIDSDDDDDDDVPVKRAASDSEEETHPKGKASDSEDEAPSKQPSDSEEETPAKVAANDSEDEFPRMKRKIVSSDDSDDEDDRKPLQKKKKSPRRSSESDSSDKVDGKKLQASESDEEGEKASKKKKSNIVSDSEDEDAADKSGNKKSRILSDGEDSDSDAASEKPKQKKKKSASSDSEEEDERKSKTETKSADKLFGSESDSENEEENLIADIFGESGDEEEEEFTGFNQEDLEGEKTVTSVNRQQAAAADSDSDDDMKSGKMGDYKSDFDLMLERKKSMSGKQRRNRDGGTFISDADDVVNAMIMKMTEAAEEDRNLNSSKKPALKKLTLLPTVVMHLKKQDLKETFIDSGVMSAIKEWLTPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAIMYLYKHPKESRPNKDIAGKLINEWSRPIFGLTSNYKGMTREEREQRDIEQMPQRRRMSSSGGQTPRRDLDKVLTGEEKALRPGEPGFCARARVPLPSNKDYVVRPKWNVEMETSQYQGSAKKGVSRIDKQMRKFVDIKKKNRFGHAVKISIEGNKMPL
What is the function of this protein?
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts.
What are the official names of this protein?
Protein IWS1 homolog A, IWS1-like protein A.
What is the protein family that this protein belongs to?
Belongs to the IWS1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1845_STAAM
Sequence: MAVNLYDYANQLEQALRESEEYKAIKEAFANVKANEESKKLFDEFRETQINFQQKQMQGEEIAEEDLQKAQEQAQAIEKDENISALMNAEQKMSQVFQEINQIIVKPLDEIYAD
What are the official names of this protein?
UPF0342 protein SAV1845.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: SMG8_DROSI
Sequence: MLDDYYTWTYPDIPENVAQELLQLNGSLVVVGVVGRSDCDLANKMLAFGMEPPDDHTPEDGQIQCYYKPGTFSLLLHFESTYDAEISGQMIDVCIEDVDTPFDIDSFFERIRCRFVRMMLLALHVCHIVVYVENGLTFDPTLLTVFQLAKFAREQHLMQFLPQMLRETPAARISERTRLCAPRILFLFENFPGDEPKTRESVSTCEFQMEDCIYELLGRYNIVTNSSSNSLVALPNNKQFVFFNAHEELRDDKLLKAIDCLNETMYKPDLKEEEEDLEILAMAPFDGFVKPFTMPVYEKEWENLQYQEDHTVWNFLQRHVQDALVGCFDAGSFKQHAQQGPFQLLNSQEWHDCMATMHKLLVENAKDPDHETSNEEYKLFLKNFDEDLNYEKKFWAHLCELGLKKGIAAYKNAAPANYGTATHRQLLADATLAFEEEGRGPQAQAALAKLAAICHNHWEDGRQQCELLSLRSHPCTLPKNMPHEKHNSGVIHISTCNCGRTQGRREDPFNLRQANYEFYELIAQMCNLCVKVKQYQFPIFEPSVSDYRAAAFEAAFPLLNTGKSGAPQDEDAGEDEAEEEEGQERELPTKKKLQNTASNCCSHPLSPTFGSDLNMSIAGFGASLKESQASSEQLSNSEQNTTSSGTSSADTENELVVELQEPAKKEAREDVGPTDAVSTSTTEYLPGLVHTVSNFGLLPLFPSWSLACVGPSSIYSHNTGLQEHFQSGFLSGANFLLPWDVQLRLVHALKQQYQQQHHGKKQQRWKKQGDRLSLKIFVGMEYECSRGHRFMMCAPDRVLRGGADIERDTCSKVVHNNMPLYYPCPCRSQRNFLAQLMRIHVVTPKAPVNIIVDPKVCVGRYTFTLGSIVPPRLSQSAYWIIRLPYVYQGDDVLIAPPDHLDPDYPLAGGYLLPGMFGVVETDPTLDLNEPGMMGASAAGNFTRI
What is the function of this protein?
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity).
What are the official names of this protein?
Nonsense-mediated mRNA decay factor SMG8, Protein smg-8 homolog.
What is the protein family that this protein belongs to?
Belongs to the SMG8 family.
Protein: CASP6_CHICK
Sequence: MSGAERRPAAGRVQLDSKPTPTTTADGNQNITEVDAFDKRQTFDPAVQYKMNHQRRGVALIFNHEHFFWHLRLPDRRGTLADRNNLKRSLTDLGFEVRIFDDLKAEDVLKKVFEASRDDYSNADCFVCVFLSHGENDHVYAYDAQIKIETITNMFRGDKCQSLVGKPKIFIIQACRGDKHDDPVLVQDSVDSKDETTVNQTEVDAAGVYTLPAGADFIMCYSVAQGYFSHRETVNGSWYIQDLCEALGKHGSSLEFTELLTVVNRKVSHRKVDICRDINAIGKKQIPCFASMLTKKLYFHPKSK
What is the function of this protein?
Cysteine protease that plays essential roles in programmed cell death, development and innate immunity (PubMed:11953316).  Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein lamin-A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed:11953316).  Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution (PubMed:11953316).  Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity.  PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis (By similarity).
What are the official names of this protein?
Caspase-6, CASP-6.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RBL_ROSDA
Sequence: MSPQTETKASVGFKAGVKDYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGQAVA
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MLF1_MOUSE
Sequence: MFRMLSSSFEDDPFFADSFLAHRESMRNMMRSFSEPLGRDLLSISDGRGRTHNRRERDDGEDSLTHADVNPFQTMDRMMANMRSGIQELQRNFGQLSMDPNGHSFCSSSVMTYSKVGDEPPKVFQASTQTRRAPGGVKETRKAMRDSDSGLERMAVGHHIHDRGHVIRKSKNNKTGDEEVNQEFINMNESDAHAFDDEWQNEVLKYKSIGRSGNTGMRSVGHEHPGSRELKRREKIHRNSAIESGRRSNVFVDKLNVKGSPVKITKK
What is the function of this protein?
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation.  Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels.  Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.  Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
What are the official names of this protein?
Myeloid leukemia factor 1, Hematopoietic lineage switch 7, Myelodysplasia-myeloid leukemia factor 1.
What is the protein family that this protein belongs to?
Belongs to the MLF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Shuttles between the cytoplasm and nucleus.
Protein: RL18_BACAN
Sequence: MITKADKNATRKKRHARVRAKLTGTAERPRLNVFRSNQHIYAQVIDDVNGVTLVSASTLDKDLALNGTSNIEAATKVGESVAKRAVEKGVKEVVFDRGGYLYHGRVKALAEAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: NFUA_SHESM
Sequence: MITISDAAQAHFVKLLADQPEGTHIRVFVISPGTAQAECGVSYCPPDAVESDDIELEFNGFSAMVDEKSAPFLEEASIDFVTDQLGSQLTLKAPNAKMRKVASDAPLAERVEYVIQSEINPQLASHGGNIMLVEITQEGVAVLQFGGGCNGCSQVDITLKDGIEKQLLDMFPGELSGVSDVTDHQHGAHSYA
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: RSMC_SALDC
Sequence: MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPARFECAASRAHTQQFHHWQVLSRQMGDNVRFSLVAQASDVADCDTLIYYWPKNKPEAQFQLMNILSLMPSGVDVFVVGENRSGVRSAEPMLADYAPLNKVDSARRCGLYHGRLEKQPQFSLESWWAEYNIDGLTIKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSAALASHSPKVRLTLCDVSAPAVEASRATLAANGLEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPKILDETFGFHEVIAQTGRFKVYRTVMTRQAKK
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL34_HCMVA
Sequence: MNFIITTRDFSNDDSVLRAAEMRDNVAGSISKAYKGTVRAEGKKKLLLKHLPVPPGGCSRRNSNLFVFCTERDYRKFHQGIAQLKRAPAELDPHEIQQVTASIRCRLQPSLREPPTPADELQTAVSRVCALFNQLVFTAQLRHYCEHQDKVVSYARDELTKRCGEKSALGVEVHQLVALLPHERHRELCHVLIGLLHQTPHMWARSIRLIGHLRHYLQNSFLHLLMNSGLDIAQVFDGCYHSEAYRMLFQIGHTDSVSAALELSHGAAAGPPEADENNDEGEEDDDELRHSDPAPLHESKKPRNARRPRTRVPPHEQKPEENEEEEEELFPSCKATAAFLRAEPSVSNDDGNGGERCDTLATALRHRADEEDGPLASQTAVRVAATPSPSVTPALTPVTSPITPLCI
What is the function of this protein?
Acts as a transcriptional repressor of the US3 gene expression through a specific DNA sequence named the transcriptional repressive element (tre).
What are the official names of this protein?
Transcriptional regulator UL34.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 UL34 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ADA28_HUMAN
Sequence: MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA
What is the function of this protein?
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L.  May be involved in sperm maturation.
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 28, ADAM 28, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II, eMDC II, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, MDC-L.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: LEUC_SHIF8
Sequence: MAKTLYEKLFDAHVVYEAENETPLLYIDRHLVHEVTSPQAFDGLRAHGRPVRQPGKTFATMDHNVSTQTKDINACGEMARIQMQELIKNCKEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGKDFDDAVAYWKTLQTDEGATFDTVVTLQAEEISPQVTWGTNPGQVISVNDNIPDPASFADPVERASAEKALAYMGLKPGIPLIEVAIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRNIK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: CLPX_YEREN
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSSLPTPHEIRRHLDDYVIGQEPAKKVLAVAVYNHYKRLRNGDTSNGIELGKSNILLIGPTGSGKTLLAETLARFLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTIAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVIGQRINTGSGIGFGATVKGKSEKATEGELLRQAEPEDLIKFGLIPEFIGRLPVVATLSELSEDALIQILKEPKNALTKQYQALFNLEGVELEFRDEALTAIAKKAMARKTGARGLRSIVEGALLDTMYDLPSMESVEKVVVDESVIAGQSAPMLIYGQPEAQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: CNOT7_XENLA
Sequence: MPAATVDHSQRICEVWACNLDDQMKRIRQVIRKYNYVAMDTEFPGVVARPIGEFRSNADYQYQLLRCNVDLLKIIQLGLTFMNEQGEYPPGTSTWQFNFKFNLTEDMYAQDSIELLTSSGIQFKKHEEEGIETQYFAELFMTSGVVLCEGVKWLSFHSGYDFGYLIKILTNSNLPEVEQDFFEILRLFFPVIYDVKYLMKSCKNLKGGLQEVAEQLELERIGPQHQAGSDSLLTGMAFFKMREMFFEDHIDDAKYCGHLYGLGSGSSYVQNGTGNAYEEEANKQS
What is the function of this protein?
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate.  Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.  During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation.  Additional complex functions may be a consequence of its influence on mRNA expression.
What are the official names of this protein?
CCR4-NOT transcription complex subunit 7, CCR4-associated factor 1, CAF-1.
What is the protein family that this protein belongs to?
Belongs to the CAF1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: GCH1_HISS2
Sequence: MSNLSPEAIKVRNALVEKGIETPMIDLVQDKDQRRQGIEQHMREVIKLIGLDLSDDSLEETPARLSKMFIDEIFSGLDYANFPKITNIENRMKVSEMVLVDDVTLTSTCEHHFVTIDGKVSVAYYPQKWVIGLSKINRVVAFFAQRPQVQERLTQQILLAFQTILETEDVAVYVKATHFCVKCRGIKDTNSYTVTSAFGGVFLDDRETRKEFLTLLKK
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: SFGH2_ECO57
Sequence: MEMLEEHRCFEGWQQRWRHDSSTLNCPMTFSIFLPPPRDHTPPPVLYWLSGLTCNDENFTTKAGAQRVAAELGIVLVMPDTSPRGEKVANDDGYDLGQGAGFYLNATQPPWATHYRMYDYLRDELPALVQSQFNVSDRCAISGHSMGGHGALIMALKNPGKYTSVSAFAPIVNPCSVPWGIKAFSRYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAARQKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQYLLK
What is the function of this protein?
Serine hydrolase involved in the detoxification of formaldehyde.  Hydrolyzes S-formylglutathione to glutathione and formate (By similarity).
What are the official names of this protein?
S-formylglutathione hydrolase YeiG, FGH.
What is the protein family that this protein belongs to?
Belongs to the esterase D family.
Protein: AAAD_HUMAN
Sequence: MGRKSLYLLIVGILIAYYIYTPLPDNVEEPWRMMWINAHLKTIQNLATFVELLGLHHFMDSFKVVGSFDEVPPTSDENVTVTETKFNNILVRVYVPKRKSEALRRGLFYIHGGGWCVGSAALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDVYNALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAVTQQLLDDPDVKIKLKIQSLIYPALQPLDVDLPSYQENSNFLFLSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSHLFKFVNWSSLLPERFIKGHVYNNPNYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPLTYVITCQYDLLRDDGLMYVTRLRNTGVQVTHNHVEDGFHGAFSFLGLKISHRLINQYIEWLKENL
What is the function of this protein?
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly.  Displays serine esterase activity in liver.  Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
What are the official names of this protein?
Arylacetamide deacetylase.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
Protein: HIS1_IGNH4
Sequence: MRFVIPSKGRLKDATLELLERAGIRPSYLDSRALIVPSNKPNLDLVFARPEDIPWIVESGAAEVGITGHDYVLESGRDVAEILDLNYGRSKLVLAVPRDSGIKRPEELPKGFRIATKFINIATDYFEKKGLDVKIVKVSGSAEVMPGIGAADGIIDVMSTGTTLKLHGLTPIDVILSSSARLIVRKDLLDDPRVETIKLMLESVLRASKKKLVMMNVPDEALDDVLKVLPAMSGPTISKVKSEKPMWEVIAAVDEDEIADIIVKLKNAGAKDILVLNVERLIP
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_COXBR
Sequence: MVYAHNLGFPRIGIKREMKKTVEAYWRGEISQQQLQQQAIELQLTNWKIQAEAGVDLIPVGDFSWYDHVLDMAVRVGAIPSRFKALNSNITDTMFCMARGQAPNGIETSACEMTKWFDTNYHYIVPEFTTNQSFELHHDDLFKSTKLALENNYRAKPVILGPLSFLWLGKCKGESFNKLLLLEKLLPVYAEIFEQLSSLGVEWVQVDEPILVLDLPPEWQQAFLTTYQQLNFFNLKCLLATYFGSLDDNLSLTCQLPVDGLHIDYCRAPDQLDSVLSQLPAEKILSVGIIDGRNIWCNDLNRSLTLLENIQSSLGDRLWVAPSCSLLHVPIDLDQENKLDVELKSWFAFAKQKVAEAAFLTRGLREGRESIGAELKKNEEVIISRKTSKRIHNPNVEKKAASVTERLMRRQHEHSIRKNKQTAQLNLPLFPTTTIGSFPQTSQIRCLRRDYKQGKIDDALYEEKIRQEIAEVIGIQVKLGLDVLVHGELERNDMVEYFGELLDGIAITSNGWVQSYGSRCVKPPIIFGDVSRERPMTLRWIEYAQSLTTKSVKGMLTGPVTILAWSFVRDDQPRSQTAKQIALALRDEVQDLERSGVRVIQIDEPAFRECLPLRKAAWQDYLEWAVKCFRLASCGVKDETQIHTHMCYSEFNDIIEAIAALDADVITIESSRSEMEILKSFEKFAYPNDIGPGIYDIHSPRIPRVAEIEELAVRALQYIPIERLWINPDCGLKTRNWEETKEALSRMVDAAKHLRKAFSSEKTPTIDLELQPAST
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.