PharMolix/UniProtQA huggingface dataset:
Protein: PARA_ECOLX
Sequence: MSDSSQLHKVAQRANRMLNVLTEQVQLQKDELHANEFYQVYAKAALAKLPLLTRANVDYAVSEMEEKGYVFDKRPAGSSMKYAMSIQNIIDIYEHRGVPKYRDRYSEAYVIFISNLKGGVSKTVSTVSLAHAMRAHPHLLMEDLRILVIDLDPQSSATMFLSHKHSIGIVNATSAQAMLQNVSREELLEEFIVPSVVPGVDVMPASIDDAFIASDWRELCNEHLPGQNIHAVLKENVIDKLKSDYDFILVDSGPHLDAFLKNALASANILFTPLPPATVDFHSSLKYVARLPELVKLISDEGCECQLATNIGFMSKLSNKADHKYCHSLAKEVFGGDMLDVFLPRLDGFERCGESFDTVISANPATYVGSADALKNARIAAEDFAKAVFDRIEFIRSN
What is the function of this protein?
This protein is essential for plasmid partition.  It ensures the proper distribution of newly replicated plasmids to daughter cells during cell division.  ParA is trans-acting.
What are the official names of this protein?
Plasmid partition protein A.
What is the protein family that this protein belongs to?
Belongs to the ParA family.
Protein: TRPB_BORPE
Sequence: MKPYDLPDARGHFGPYGGVFVAETLMHALDELRAAYDQCRVDPSFIDEFNYELKHFVGRPSPVYHASRWSQRLGGAQIWFKREDLNHTGAHKVNNCIGQALLARRMGKPRVIAETGAGQHGVATATVAARYGMECVVFMGSEDVRRQASNVYRMKLLGATVVPVDSGSCTLKDALNEAMRDWVTNIENTFYIIGTVAGPDPYPRMVRDFQTVIGQECLTQMPEVIGRQPDYVVAAVGGGSNAMGIFHPYIPYENVRLIGVEAAGEGMETGRHAASLAAGQIGVLHGNRTYVMQNADGQVQETHSVSAGLDYPGVGPEHAWLKDSGRAEYAGITDDEALAAFHDCCRIEGIMPALESAHAIAQAVKMTPALSKDKVILVNLSGRGDKDMHTVAERAGLQL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: CYFIP_CAEEL
Sequence: MNANVTVDDAISNVNLLDTLAIPDDLPDIEARALPLLYRSNFDTNFEDRSAFVTGIAKYSEEATRHAQFNDMLSEGLQHAANMYTWRCCSRAVPMAKSNDQPNRTEINEMVVEVLKPEVSKLGSFMRFTLTAIQRFCEEVRRLCHSEKRRDFVSEAYLLTLGRFINMFAVLDELKNMKASIKNDFSTFRRASQFLTAMSDTQAVHDMQNLSMFLATQNKIKDDLKLQMKTIEGYEELLCDVVNICAHMYEHQLYLSPNEKHMFVKVIAFSLFLMDGDAANVAKLDQKKRLSISRLDKIFKTLEVVPLYGDMQIQPFAFVRRSSHYEPSKWPLSDKESDRCHVNIVEKVQSIRSDHESYVTQFAKINNEVAICDRPGNDSENREITSLALSGIQLLCQWSCAVVETISWKLLNPTNPKDNRECPENAEEYERATRYNYSPAEKTALIQIIAMIKGLQSMLGKTESDMSNSTRKCVYVELQAFIHHTINEPLQKAVKHKKDLLASILQSVKDSISDAGNELNRMTDVKGKKKSSAPKGDSANSSSSDIRIPRRTAAPGSTQLYMARTQLESLISDKLCGGKKILRKELDSKTIEKISVFLRKSAHWPALFRLSDSMTEAGELSQLWFREFYLEMTMGQRIQFPIEMSMPWILTDYILSCNEPSLIESALYQLDLYNDAAQYSLFNFNKQFLYDEVEAEVNLCFDQFVYKLSEMVFTHYKQLASCMLLDKRFKAEILRSGTMIRSPSAARFESLLQQRHVQLLGRSVDLNRVVSQRVNMALLKALDAAIWKFESEPLSSIVELDMLIDTNRLCHTLLSDVLHSIAPFDDLFQEANHAVNSPHGRITLHVFWELNYDFVPNFVYNGSTHRFVRARHVFRKTPAREKPPQVGQVYYWGSKSLMAAFMNICNAYSQCIGTQHLKAITRLLHYQGIAVILDELLKMTNRLLNDKIRRHVRNVFNMMPKVCKLPRSDYGSNALLQYYVHHLEAVGKYPELKSEFCQDLRELGNMIVFCQQLEVALGQEEAHDLFLAAAYTGTVPQPPARNAQEQMKQLAKLEDKYSRIHLTEIIDKISPDDGQAAIAKDAELMTKERLCCGLNAFENFLVRIKQMLAADDIWTGGYPTNGVFWIDECVEWYRVYSALQFFLCQPTRDDNEVYAEELFGDSLQWGGLTLITLLGQHRRFEVLDFCYHLHRVNKADGKDEVISGIRLAKMVERIRRFQLLNNQIFIILENQLNENNDDPNERVREFAPPVHPNYANHAARRQ
What is the function of this protein?
Required for initial steps of body morphogenesis (PubMed:11877381).  May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448).  Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).
What are the official names of this protein?
Cytoplasmic FMR1-interacting protein homolog, Gut on exterior protein 2.
What is the protein family that this protein belongs to?
Belongs to the CYFIP family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Enriched at cell boundaries.
Protein: ANG2_BOVIN
Sequence: QNDAYRGFLRKHYDPSPTGHDDRYCNTMMERRNMTRPCKDTNTFIHGNSDDIRAVCDDRNGEPYRNGLRRSRSPFQVTTCRHRGGSPRPPCRYRAFRANRVIVIRCRDGFPIHLEENFIPPRP
What is the function of this protein?
Binds tightly to placental ribonuclease inhibitor and has very low ribonuclease activity.  Has potent angiogenic activity.  Angiogenin induces vascularization of normal and malignant tissues.  Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs.
What are the official names of this protein?
Angiogenin-2.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).
Protein: SPB1_RAT
Sequence: MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQEDITTERCRQALRKELKTWKVDVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARGGCFITKVFRSRDYQPLLWIFQQLFHRVQATKPQASRHESAEIFVVCQGFLAPDKVDAKFFDPKFAFKEVEVQAKTVTELVTKKKPKAEGYAEGDLTLYHRTSVTDFLRAANPVDFLSKASEISIDDKELAQHPATTEDIRACCQDIKVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSEEEGDEEESAAETKQASEEEEEREEEEQLNRTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLRTIRGQQLLEEVTQGDMNAADTFLSDLPRDDIYVSDAEDDDDTSLESDLDPEELAGVRTHSDQKEQKSLQFAQVDDSKEEEGENPLLVPLEEKAVLQEEQASLWFSKDGFSGIDDDADEALEISQAQLLYKSRQKEQQPTDPPPPPTNLKTEKKSSQCQNEVPKETEAITDTGGEDRDSSDSDSSSSEDEDDWKVSRGKKRSRGSKADEDGFEVVPIEDPVKYRILDPEGLALGAVIASSKKAKRDLIDNSFNRYAFNEEEEELPEWFVQEEKQHRIRQLPLDKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKKLEQTKKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRQVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQRKEQKRNHRRK
What is the function of this protein?
RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
What are the official names of this protein?
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3, Protein ftsJ homolog 3, Putative rRNA methyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CBIA_LISMF
Sequence: MNKILIAAASSGTGKTTITLGIMHALKKRGLRVQPFKVGPDYIDTNYHQAITGVASINLDSFLIDDDAMLATLFQKHGESADISVIEGVMGLFDGLGIDRDNSSTSFIAKCTKTPVILVVDGKAISTSAAAIVDGFNRFDPELTIAGVIINRVASENHFSLIKGAIERYTDVPVLGYLPKNAAVALPERHLGLVPKEEMTELETKWELLGDLIAEHVDLDRLLAISKTGAKLTVHPPEIQVPDFSGVRVAYALDAAFHFYYQDNLDFIRSTGATLIPFSPLEEREVPDADFIYIGGGFPEVFAEQLAKNKSMRESILAAHEQGKPIYAECGGLMYLGSSLEMEAESYEMVGVFDGVSKMTTRLRKFGYCIAEPLEDTLLGKKGTAIRGHEFHHSVFETTEPTRMKLTKKRDGKIVKEWHGGYQKGNTFASYLHIHFYQNLLIITHMFGAIER
What is the function of this protein?
Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
What are the official names of this protein?
Cobyrinate a,c-diamide synthase, Cobyrinic acid a,c-diamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CbiA family.
Protein: Y1057_MYCMM
Sequence: MARTHDDKWDLASSVGATATMVAAGRAMASRDPRGLIDDPFAEPLVRAVGVDFFIKMMDGEFDLSVLQNVSSAKAQAMVDGMAVRTKYFDDYFGDAIKSGIRQAVILASGLDARAYRLPWPADTVVYELDQPQVIEFKTNVLADLGAEPRATRRAIPIDLRGDWPVALRAAGLDTTAPTAWLAEGLLIYLPPEAQDRLFDNITALSAPGSTVATEFVPGIVDFDVDRARQMSGPFRDHGLDIDMSSLVYTGARNHVVDYLRAKGWDAEGVTRSELFERNGMAVPAPSDDDPLGEIIFISAALTG
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MMAR_1057.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: SUFE_ECOUT
Sequence: MALLPDKEKLLRNFLRCANWEEKYLYIIELGQRLPELRDEDKSPQNSIQGCQSQVWIVMRQNAQGIIELHGDSDAAIVKGLIAVVFILYDQMTPQDIVNFDVRPWFEKMALTQHLTPSRSQGLEAMIRAIRAKAAALS
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_BURTA
Sequence: MIIHPNFDPVAIHLGPLAVRWYGLMYLVGFILAIVVGRLRLKLPHVAAQGWSAKDIDDMMFYGVLGVVLGGRLGYVLFYKADYYFSHPLDIFRVWEGGMSFHGGFLGVTLAMALFAWQRKRHWLEVTDFVAPMVPTGLAAGRLGNFINGELWGRVTSPDAPWAMLFPGASRDDAAWLAAHQDIAAKWNLNEVFLAHQMLPRHPSQLYEIALEGIALFFVLWFFSRKPRPMGAISALFLIGYGAARFTVEFAREPDDFLGLLTFGLSMGQWLSLPMIVAGVLMMIWAYRRGGAAKAA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SUCC_ANASK
Sequence: MKIHEYQAKEILRKFGVAVPRGYLAVTPLEAEGAARQLGGGISAVKAQIHAGGRGKGGGVKLARSPDEARQHAEAMLGMMLKTPQTGPDGQEVRKVYVEEGCRIARELYLGMTLDREIGRLAVMASVEGGVDIEEVAAKHPDKILREWISPLTGLMPFQARRLAFGLGLTGDSVTAFVRFATGLYNAYVATDASLAEINPLVITVGGEVLALDAKMNFDDNALYRHPDIAAMRDPDEEDPKETQAKEYDLSYIALDGDIGCMVNGAGLAMATMDVIKLSGGQPANFLDVGGGADEDKVTAAFKIILSDPHVKAVLVNIFGGIMKCDVIANGIVAAAKQVGLSIPLVVRLEGTNVELGKDILAHSELKIIPADDLGDAARKVVQAARAA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: DCUP_CHLPD
Sequence: MLKNDLFLRALKRQPCSRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELAAEVTIQPVDLMGVDAAIIFSDILVVNEAMGMDVEIIESKGIRLSPAIRSQVDIDRLIIPDINEKLGYVMDAIRLTKKELDNRVPLIGFSGAAWTLFTYAVEGGGSKNYAFAKKMMYREPKMAHMLLSKISSVITEYVLMQIEAGADAIQIFDSWASALSEDDYREFALPYIKENVQAIKTKYPDTPVIVFSKDCNTILSEIADTGCDAMGLGWNMDIAKARKELNDRVCIQGNMDPTVLYGTPDKIRSEAAKILKQFGQHTATSGHVFNLGHGILPDVDPANLKLLVEFVKEESVKYH
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTC_PROMP
Sequence: MIKPNRLANKNFLSSLDITTDEVFHILDLSKKFKNKKLNINLHNKVLGLIFDKSSTRTRVSFQVAMSRLGGTTIDLNPTTSQIERGEPIKDTARVLSRYCDVIAIRTFNHADLEEYARWSTKPVINALTDLEHPCQALADFLTIYEEFLDFKDVVLTFIGDGNNVANSLILCGALLGVEVRIACPKGYEPNSMVINKAYEIYKNRNLLKITNDPDTAVLGANVLYTDVWSSMGEENQKAEKDKVFNGFTIDNDLVSKADKEAIILHCLPAYRSKEITDEVFESKKNRIFDQAENRMHVQQALLSCLLY
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE2_ORITB
Sequence: MTVITRFAPSPTGKLHIGNVRVALVNWLYAQKYNGNFILRIDDTDRDRSKVEYHEAIIKDLQWLGINWNSSFLQSIRFNKYKAAKQYLISSGRLYECYETPEMLEIERKRQLTSGYPPIYSRKALELTKAQKVQLQAEGYKVHYRFLIDRNKPIIWNDLIKGEIKYDGSNISDPIVIKEDGTMIYMLCSVIDDIEYRISHIIRGEDHITNTAIQIQMFEALGAAIPQLGHLSLIKSDSGKISKRIGGFTIDYLRDQLGIEPMAVNNLLALSGTSNNVDAYFSLESLITKFDLSAFSKSAIIYNENELVTLNHKLLVNTEYDTIKHRLTAIGLPDVTKEFWLAVRHNLNTLNDIKIWWQICYLPTLDKFQEQDAEFLKLAAGLLPSGKLTDNSWDDWVQNIIKATNRRGKALFMPLRLALTGITYGPELKYLLPLIGGEEVKARLLRHQ
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_ALKEH
Sequence: MRCPYCQFEDTRVIDSRLASEGEQVRRRRECNRCGERFTTYETAELALPRIVKRDGTREPWDEGKLRQGMLRALEKRPVATEAVEAALFRIRQRLRATGEREVSASQLGEWVMEELRELDQVAYVRFASVYRSFEDVSAFREVIEGLEKR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: YP007_HUMAN
Sequence: MLVETGFCRVGQAGLELLSSSDKAAGLDLPKCWDYRHEPPRLAPLLIFNPHPSTVLSCNCEYNSFFEFCDSLQQIVIPERVLGTPRHIFPLPLLFSHFLWSKLKEAPACLLQGSSEHTEIICDLISSSKQFIKKFLSNKPSALHGGDADENDFLQLITRLQKLLFKSLSMYVCVHIHQHTHACPQLSCLHQNQDEELFYCQN
What are the official names of this protein?
Putative uncharacterized protein FLJ45256.
Protein: TATA_METSB
Sequence: MGSLSIWHWLIVGAVVLLVFGGKGKISDIMGDVAKGIKSFKRGLSEDEEKAEAKPVGEPSLRSLDHQGAGDPLKTPDARKIG
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DDL_BACFN
Sequence: MKRNIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLYIVEMEGRRWEVQLQDGSKTPVDRNDFSFMNGAEKVVFDFAYITIHGTPGEDGRLQGYFDMIRIPYSCCGVLAAAITYDKFVCNQYLKAFGVRISESLLLRQGQAVSDEDVVEKIGLPCFIKPNLGGSSFGVTKVKTREQIQPAIAKAFSEAEEVMIEAFMGGTELTCGCYKTKEKSVVFPLTEVVTHNEFFDYDAKYNGQVDEITPARISEELTRRVQTLTSAIYDILGCSGIIRVDYIITEGEKINLLEVNTTPGMTATSFIPQQVRAAGLDIKDVMTDIIENKF
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUTF_YERE8
Sequence: MQTQSLPTDSLPASSALRSVAVDKQDFRDAMARLGSAVNIITTDGPAGRAGFTASAVCSVTDTPPTLLVCLNRSASVYSVFQQNQTLCVNTLCAEHESLSNLFGGKTPMEMRFSAARWSTLVTGCPVLSGAVASFDCHITQVISVGTHDILFCQAAAVIHNDDQHGLAYFDRCYHPLMRQSR
What is the function of this protein?
Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.
What are the official names of this protein?
FMN reductase (NADH) RutF, FMN reductase, NADH-flavin reductase RutF, NADH:flavin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
Protein: BMRU_BACSU
Sequence: MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKKKDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVLGIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKISYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGLLDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYTHTPAVIQVLPQHIDMLVPANE
What is the function of this protein?
May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG).  In fact, is not able to exhibit diacylglycerol kinase activity in vitro.
What are the official names of this protein?
Putative lipid kinase BmrU.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family.
Protein: PARG1_ARATH
Sequence: MENREDLNSILPYLPLVIRSSSLYWPPRVVEALKAMSEGPSHSQVDSGEVLRQAIFDMRRSLSFSTLEPSASNGYAFLFDELIDEKESKRWFDEIIPALASLLLQFPSLLEVHFQNADNIVSGIKTGLRLLNSQQAGIVFLSQELIGALLACSFFCLFPDDNRGAKHLPVINFDHLFASLYISYSQSQESKIRCIMHYFERFCSCVPIGIVSFERKITAAPDADFWSKSDVSLCAFKVHSFGLIEDQPDNALEVDFANKYLGGGSLSRGCVQEEIRFMINPELIAGMLFLPRMDDNEAIEIVGAERFSCYTGYASSFRFAGEYIDKKAMDPFKRRRTRIVAIDALCTPKMRHFKDICLLREINKALCGFLNCSKAWEHQNIFMDEGDNEIQLVRNGRDSGLLRTETTASHRTPLNDVEMNREKPANNLIRDFYVEGVDNEDHEDDGVATGNWGCGVFGGDPELKATIQWLAASQTRRPFISYYTFGVEALRNLDQVTKWILSHKWTVGDLWNMMLEYSAQRLYKQTSVGFFSWLLPSLATTNKAIQPP
What is the function of this protein?
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (By similarity).  Involved in establishing period length of the circadian oscillator.  May regulate post-translational poly(ADP-ribosyl)ation of an oscillator component.
What are the official names of this protein?
Poly(ADP-ribose) glycohydrolase 1.
What is the protein family that this protein belongs to?
Belongs to the poly(ADP-ribose) glycohydrolase family.
Protein: SYI_FERPD
Sequence: MDYKATLNLPQTNFQMKANLVNKEPEMLKFWEEKEIYKKTLETRANAPTYLLHDGPPYANGDIHLGTAMNKILKDFVTRYKTMRGYRVPFVPGWDTHGLPIEHRVTTSLGEEAKKKSPAEIRKLCKEFALKYVDIQREEFKRLGVKGDWEHPYITLDPDYEYHILDVFKTLVENGNVYRGNKPVYWCPTCRTALAEAEIEYHDHESPSIYVKFQMVDKPDTYIVIWTTTPWTIPANVAIALHPDYTYVKIKVDEEYWIVAEGLLQKFAADVGIDFEVVEKFVGKELEGKLTKHPLYDRTSVVVLADYVTLEDGTGCVHTAPGHGEEDYQTGLKYNLPVLSPVDDEGRFTKEAGKYEGLKIWDANKVIVEDLKNNGSLIKAGKISHSYPHCWRCKGPVMFRATPQWFISVDKNNLRGKVLEEIKKVKWYPAWGETRITAMVQERPDWTISRQRVWGVPIPAVKCKDCGEVTLEPKVIEHFANIVKEKGTDAWFELDVNELIPADFKCPACGSKNFEKTHDTLDVWIDSGCSWEAVIRSKGERFPVDLYLEGDDQHRGWFQSSIFLSTAKAGTAPFKAVVTHGFIKDEQGRKMSKSLGNVIDPMEIVNKYGADILRLWVASTDFFDNIRVGKNIIEQQVEVYRKLRNTLRYLLSNLYDFTEADLLPYEKLLPLDKWALGRLQKFIEQITQYYEGFEYSKVYNATVKYCTTELSAVYLDILKDRLYVEAKDSIYRRSAQTALHYILEALIKILAPIIPFTAEEAYQESHLKRYESVHLEYWPEVRKEFIDEALLEEFDHLLLIRDDVLKALENARASDIIGHSLDAHVIIEAKNEELKNLLRKYESLLEEFFIVSKVTLSENISGLNGQFANVLVQRAEGQKCQRCWKYHPDTGKDLEHPETCPRCSAVLRGERK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNDD3_HUMAN
Sequence: MVALRGLGSGLQPWCPLDLRLEWVDTVWELDFTETEPLDPSIEAEIIETGLAAFTKLYESLLPFATGEHGSMESIWTFFIENNVSHSTLVALFYHFVQIVHKKNVSVQYREYGLHAAGLYFLLLEVPGSVANQVFHPVMFDKCIQTLKKSWPQESNLNRKRKKEQPKSSQANPGRHRKRGKPPRREDIEMDEIIEEQEDENICFSARDLSQIRNAIFHLLKNFLRLLPKFSLKEKPQCVQNCIEVFVSLTNFEPVLHECHVTQARALNQAKYIPELAYYGLYLLCSPIHGEGDKVISCVFHQMLSVILMLEVGEGSHRAPLAVTSQVINCRNQAVQFISALVDELKESIFPVVRILLQHICAKVVDKSEYRTFAAQSLVQLLSKLPCGEYAMFIAWLYKYSRSSKIPHRVFTLDVVLALLELPEREVDNTLSLEHQKFLKHKFLVQEIMFDRCLDKAPTVRSKALSSFAHCLELTVTSASESILELLINSPTFSVIESHPGTLLRNSSAFSYQRQTSNRSEPSGEINIDSSGETVGSGERCVMAMLRRRIRDEKTNVRKSALQVLVSILKHCDVSGMKEDLWILQDQCRDPAVSVRKQALQSLTELLMAQPRCVQIQKAWLRGVVPVVMDCESTVQEKALEFLDQLLLQNIRHHSHFHSGDDSQVLAWALLTLLTTESQELSRYLNKAFHIWSKKEKFSPTFINNVISHTGTEHSAPAWMLLSKIAGSSPRLDYSRIIQSWEKISSQQNPNSNTLGHILCVIGHIAKHLPKSTRDKVTDAVKCKLNGFQWSLEVISSAVDALQRLCRASAETPAEEQELLTQVCGDVLSTCEHRLSNIVLKENGTGNMDEDLLVKYIFTLGDIAQLCPARVEKRIFLLIQSVLASSADADHSPSSQGSSEAPASQPPPQVRGSVMPSVIRAHAIITLGKLCLQHEDLAKKSIPALVRELEVCEDVAVRNNVIIVMCDLCIRYTIMVDKYIPNISMCLKDSDPFIRKQTLILLTNLLQEEFVKWKGSLFFRFVSTLIDSHPDIASFGEFCLAHLLLKRNPVMFFQHFIECIFHFNNYEKHEKYNKFPQSEREKRLFSLKGKSNKERRMKIYKFLLEHFTDEQRFNITSKICLSILACFADGILPLDLDASELLSDTFEVLSSKEIKLLAMRSKPDKDLLMEEDDMALANVVMQEAQKKLISQVQKRNFIENIIPIIISLKTVLEKNKIPALRELMHYLREVMQDYRDELKDFFAVDKQLASELEYDMKKYQEQLVQEQELAKHADVAGTAGGAEVAPVAQVALCLETVPVPAGQENPAMSPAVSQPCTPRASAGHVAVSSPTPETGPLQRLLPKARPMSLSTIAILNSVKKAVESKSRHRSRSLGVLPFTLNSGSPEKTCSQVSSYSLEQESNGEIEHVTKRAISTPEKSISDVTFGAGVSYIGTPRTPSSAKEKIEGRSQGNDILCLSLPDKPPPQPQQWNVRSPARNKDTPACSRRSLRKTPLKTAN
What is the function of this protein?
Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007).  May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids.  Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation.  Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase.  Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).
What are the official names of this protein?
Condensin-2 complex subunit D3, Non-SMC condensin II complex subunit D3, hCAP-D3.
What are the subcellular locations of this protein?
Nucleus.
Protein: S10AC_RABIT
Sequence: MTKLEDHLEGIINIFHQYSVRTGHYDTLSKCELKKLITTELVNTIKNTKDQATVDRIFRDLDEDGDHQVDFKEFLSLLASVLVTAHENIHKE
What is the function of this protein?
S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response.  Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration.  Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER).  Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1.  Acts as a monocyte and mast cell chemoattractant.  Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation.  Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites (By similarity).
What are the official names of this protein?
Protein S100-A12, Calgranulin-C, CAGC, Extracellular newly identified RAGE-binding protein, EN-RAGE, S100 calcium-binding protein A12.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule- mediated, alternative pathway (By similarity).
Protein: NRDR_SHESA
Sequence: MHCPFCSATDTKVIDSRLVAEGHQVRRRRECTECHERFTTFEGAELVMPRVIKRDGTRQPFDEEKLQAGMLRAVEKRPVSMDEIEQALSKIKSTLRATGEREVPSEMIGNLMMEQLMSLDKVAYIRFASVYRAFEDVSEFGEAIAKLQK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.