PharMolix/UniProtQA huggingface dataset:
Protein: KCNQ2_RAT
Sequence: MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
What is the function of this protein?
Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.  Therefore, it is important in the regulation of neuronal excitability.  KCNQ2 current is blocked by barium and tetraethylammonium whereas 4-aminopyridine and charybdotoxin have no effect on KCNQ2 current.  Tyrosine kinase inhibitors genistein or herbimycin a markedly down-regulate KCNQ2 current.  As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:11038262, PubMed:11230508).  KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+).  Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity).
What are the official names of this protein?
Potassium voltage-gated channel subfamily KQT member 2, KQT-like 2, Potassium channel subunit alpha KvLQT2, Voltage-gated potassium channel subunit Kv7.2.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ENV_HV1H3
Sequence: MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHAGVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLKNDTNTNSSSGRMIMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYTLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSVNFTDNAKTIIVQLNTSVEINCTRPNNNTRKKIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNATLKQIASKLREQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRIKQFINMWQEVGKAMYAPPISGQIRCSSNITGLLLTRDGGNNNNGSEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGKLLCTTAVPWNASWSNKSLEQIWNHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSVVNRVRQGYSPLSFQTHLPIPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQEAYRAIRHIPRRIRQGLERILL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: NHAC_ALKPO
Sequence: MEKKATVGFTLLLLGVMMAIIITSMFVLKVEPHIPLVVCLLIAAVFGRYLRVGWNDLESAMIDGLKIGIKPIFILALVGIVIAVWMMSGTVPTLLFYGLSIISPEWFAVSTLLICMIVSSFTGSSFTTVGTIGVAMMGIGTALGIDPAIAAGAVVCGACFGDKMSPLSDTTNFAPGIVGVDLFDHIRHLLWTTVPSFVITVILFLMIGRSQATSTTQDIQAMLTALDSQFTLSVLTLLSPLLVVILAMRRFPTIPVLVVGILTGIITAAFVQGNADVARWFTIIQNGFSMETGNEVIDGIVNRGGLQSMMWSISLVMIALTLGGVIQRIGVIDTLLQSLTRKLSSRGHLIAATATSSIGVNVVTGEQYLSILLPGKTFESFYTKLNVAKKNLSRTLEDAGTLVNPLIPWGVSGAFFASTLGVDVIDYLPFAFFLFLSPFMTILFGYLGIGVGKEQSLANKRG
What is the function of this protein?
Na(+)/H(+) antiporter.  Involved in pH homeostasis and sodium extrusion.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaC, Sodium/hydrogen antiporter, Sodium/proton antiporter.
What is the protein family that this protein belongs to?
Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SECA_YERPP
Sequence: MLIKLLTKVFGSRNDRTLRRMQKVVDVINRMEPDIEKLTDTELRAKTDEFRERLAKGEVLENLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNALSGRGVHVVTVNDYLAQRDAENNRPLFEFLGLSIGINLPNMTAPAKRAAYAADITYGTNNEFGFDYLRDNMAFSPEERVQRQLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYIRVNKLIPKLIRQEKEDSDSFQGEGHFSVDEKSRQVHLTERGLILIEQMLVEAGIMDEGESLYSPANIMLMHHVTAALRAHVLFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTIVVPTNRPMIRKDLADLVYMTEQEKIGAIIEDIRERTANGQPVLVGTISIEKSEVVSAELTKAGIEHKVLNAKFHAMEAEIVSQAGQPGAVTIATNMAGRGTDIVLGGSWQSEIAALEDPTEEQIAAIKAAWQIRHDAVLASGGLHIIGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYSQRNELLDVSDVSETINSIREDVFKTTIDSYIPTQSLEEMWDIEGLEQRLKNDFDLDMPIAKWLEDEPQLHEETLRERILQQAIETYQRKEEVVGIEMMRNFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFAMFAAMLESLKYEVISVLSKVQVRMPEEVEALEVQRREEAERLARQQQLSHQTDNSALMSEEEVKVANSLERKVGRNDPCPCGSGKKYKQCHGRLQ
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ARAD_BACSU
Sequence: MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPSGVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATSWAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQVPGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYRKHGANAYYGQS
What is the function of this protein?
Involved in the degradation of L-arabinose.  Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).
What are the official names of this protein?
L-ribulose-5-phosphate 4-epimerase, Phosphoribulose isomerase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. AraD/FucA subfamily.
Protein: RL10_MYCSJ
Sequence: MAKADKATAVADIAEQFKEATATVVTEYRGLTVANLAQLRRSLGESATYTVAKNTLVKRAAAEAGIDGLDELFTGPTAIAFVQGEPVDAAKAIKAFAKEHKALVIKGGYMEGRALSIDEVNRIADLESREVLLAKLAGAMKGNLAKAAGLFNAPASQVARLAAALQEKKAAEEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: YHAM_SALPC
Sequence: MFESKINPLWQSFILAVQEEVKPALGCTEPISLALAAAAAAAELDGTVERIDAWVSPNLMKNGMGVTVPGTGMVGLPIAAALGVLGGDAKAGLEVLKDASAKAVADAKAMLAAGHVAVMLQEPCNDILFSRAKVYSGDSWACVTIVGDHTNIVRIETDKGVVFTQADNAQEEEKTSPLGVLSHTSLEEILAFVNAVPFDAIRFILDAARLNGALSQEGLRGSWGLHIGSTLAKQCDRGLLAKDLSTAILIRTSAASDARMGGATLPAMSNSGSGNQGITATVPVMVVAEHVGADDERLARALMLSHLSAIYIHHQLPRLSALCAATTAAMGAAAGMAWLIDGRYDTIAMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHNVEQSIANLCSLACRSMQQTDKQIIEIMASKAH
What are the official names of this protein?
UPF0597 protein YhaM.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: TATC_AQUAE
Sequence: MPLTEHLRELRYRLIISIIAFLIGSGIAFYFAKYVFEILKEPILKSYPEVELITLSPTEPLFILIKISLAVGFIIASPVILYQFWRFIEPALYSHEKRAFIPLLLGSILLFMLGALFAYFIVLPLALKFLLGLGFTQLLATPYLSVDMYISFVLKLVVAFGIAFEMPIVLYVLQKAGVITPEQLASFRKYFIVIAFVIGAIIAPDVSTQVLMAIPLLLLYEISIFLGKLATRKKKEIQKA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
What are the official names of this protein?
Sec-independent protein translocase protein TatC.
What is the protein family that this protein belongs to?
Belongs to the TatC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEC_GEOSW
Sequence: MKKEKAIVVFSGGQDSTTCLFWALKQFDEVEAVTFDYGQRHRLEIEVAASIAKELGVPHTVLDMSLLNQLAPNALTRSDIAIEQNEGQLPSTFVDGRNLLFLSFAAVLAKQKGARHLVTGVCETDFSGYPDCRDIFIKSLNVTLNLAMDYQFVIHTPLMWLTKAKTWKLADELGAFDFVRTKTLTCYNGIIADGCGECPACVLRRRGLEEYMKEKEGANQL
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: DAPA_ECO8A
Sequence: MFTGSIVAIVTPMDEKGNVCRASLKKLIDYHVASGTSAIVSVGTTGESATLNHDEHADVVMMTLDLADGRIPVIAGTGANATAEAISLTQRFNDSGIVGCLTVTPYYNRPSQEGLYQHFKAIAEHTDLPQILYNVPSRTGCDLLPETVGRLAKVKNIIGIKEATGNLTRVNQIKELVSDDFVLLSGDDASALDFMQLGGHGVISVTANVAARDMAQMCKLAAEGHFAEARVINQRLMPLHNKLFVEPNPIPVKWACKELGLVATDTLRLPMTPITDSGRETVRAALKHAGLL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_RICCK
Sequence: MLRSEKSVAVEDIVNIYKESPSVIITHYHGLTVSQVSSLRESLKSQEAGFKVVKNTLAKIAANQTGLNNIVELFAGPTAIAYSKEPVGMAKLVVNFAKANDNLKIIGGVVDNHVLDKHSIKELSKLPLLNELRGKIVELLQAPATKVLGVLQAPSSSMARVIQAHASKN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: MENF_MYCTO
Sequence: MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSGTAPILLGALPFDVSRPAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPPPADYLTRIGRARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSAGNDDTGAALVGASPELLVARSGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTIPAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELIAELEGDRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRRAALAHAGGGIVAESDPDDELEETTTKFATILTALGVEQ
What is the function of this protein?
Catalyzes the conversion of chorismate to isochorismate.
What are the official names of this protein?
Putative isochorismate synthase MenF, Isochorismate mutase.
What is the protein family that this protein belongs to?
Belongs to the isochorismate synthase family.
Protein: CD33_HUMAN
Sequence: MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTHPTTGSASPKHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNPSKDTSTEYSEVRTQ
What is the function of this protein?
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212).  Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872).  Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109).  These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109).  In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109).  One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).
What are the official names of this protein?
Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
What are the subcellular locations of this protein?
[Isoform CD33M]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform CD33m]: Peroxisome. Note=CD33m isoform does not localize to cell surfaces but instead accumulates in peroxisomes.
Protein: RK1_GRATL
Sequence: MKKRSRRFSTLLKQIEADKLYSPLDALNLMKNLSNVKFIETAEVHIVLGLDPKYADQQLRTTVMLPKGTGKIMRVAVITQNNKTHEAKSSGADIVGGEDLIDEIKKGRLDFDKLIATPDMMMSIAKLGKILGPKGLMPSPKAGTVTHNLITTIKEFKAGKLEYKIDRSGILHIPFGKLNFNVEDLHINLITLQESIDRNRPQGSKGKYWKSVHINSTMGPSIPLDIQLLRNNYVL
What is the function of this protein?
Binds directly to 23S rRNA.  Might be involved in E site tRNA release (Potential).
What are the official names of this protein?
50S ribosomal protein L1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BIOW_STAAC
Sequence: MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFAAAKIGYHRLFDIKPVNTRYGGRIIFVDDCIDLNHYISFLESTPKQVVYETV
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: SFSA_PROMA
Sequence: MIGKTITNFSPLTEGILLKRYKRFLADVELDTGEVVTAHCANTGPMKGVLHVGGRVRLRHSPSPSRKLSWSWEQAQVPSGQSFSWVGVNTALPNKLVRLAIEAGCLKQELGEIFEIKNEVTYGVARKSRIDLLLTPHFNNSDSRKIFVEIKNTTWAKGSTAVFPDTVTTRGQKHLQEMINEVPSSRAVLVPCISRNDIEVFVPGDSADAKYGDLFRLALNAGVEVIPCAFDFHLDCITWEGTKPFLKGENF
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: PETL_SACSI
Sequence: MLTITSYFGFLLAALTITPALFIGLNKIRLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ARGC_HALHL
Sequence: MIEVGIVGGTGYTGMELLRLVARHPKLRLAEITSRAEAGTRVDELVPALEGAVDNVFTAPDTERLSRCDVVFFATPNGIAMESAPALLEAGCRVIDLGADFRLRDPAVWTEWYGMSHSCPELLEEAVYGLPEANRDALPGARLVANPGCYPTAVALGLLPLLEAGALADGPVVADCKSGVSGAGRAAKVATLFCEANEGFKAYGASGHRHLPEIEQTLARVAGAPVDVTFVPHLVPMTRGMQATLHVVVDRPLDELEALYRQRYADEPFVHLVASGGHPETRWVRGTNHCRIGLHQPPGRPDRAVILSVIDNLTKGAAGQAVQNLNRMFGLEETAGLEGLAYVP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_GEOTN
Sequence: MKVMERWFNVGKIVNTHGIRGEVRVISRTDFPEERYKKGNKLYIFRECDTEPIEVTVKSHRVHKSFDLLSFEGYDSINDVEPFKGAMLKVPESQLGELNEGEYYFHEIIDCTVVTEAGETIGKVKEILTPGANDVWVVRRQDGTDALIPYIDDVVMHVDPERKIIIIRPMEGLLE
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CGR1_CRYNB
Sequence: MSAEPSSSAQASAPTVVSVAPSKNGRTPGKAHKSAKTALRRSYISPSVKTPFEKRMEKEKAQQAAKQLEKELKEEKENERQRKVNIIKERRARKEEKQREEELRAKMSAKKLQRMKKREGRSKKING
What is the function of this protein?
Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
What are the official names of this protein?
rRNA-processing protein CGR1.
What is the protein family that this protein belongs to?
Belongs to the CGR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ISCA_ECO45
Sequence: MSITLSDSAAARVNTFLANRGKGFGLRLGVRTSGCSGMAYVLEFVDEPTPEDIVFEDKGVKVVVDGKSLQFLDGTQLDFVKEGLNEGFKFTNPNVKDECGCGESFHV
What is the function of this protein?
Is able to transfer iron-sulfur clusters to apo-ferredoxin.  Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically.  Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
What are the official names of this protein?
Iron-binding protein IscA, Iron-sulfur cluster assembly protein.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: RIR1_CHLMU
Sequence: MVDLQEKQCTIVKRNGMFVPFDRNRIFQALEAAFRDTRRIDDHMPLPEDLENSIRSITHQVVKEVVQKITDGQVVTVERIQDMVESQLYINGLQDVARDYVVYRDDRKAHREKSWQSLSVIRRCGTTVHFNPMKISAALEKAFRATDRIEGMTPDFVREEVNALTQKIVAEIEERCSQQDSRIDIEQIQDIVEQQLMVVGHYATAKNYILYREARARVRDNRVEDQIVEEAPSEETFEVLSKDGSTYMITHSQLLARLARACSRFPETTDAALLTDMAFSNFYSGIKESEVVLACIMAARANIEKEPDYAFVAAELLLDVVYKEALDRSRGDEDLEQVYRDHFKRYIMEGDSYRLNPELKNLFDLDALANAMDLSRDLQFSYMGIQNLYDRYFNHDDGRRLETPQIFWMRVAMGLALKEQDKTYWAITFYNLLSTFRYTPATPTLFNSGMRHSQLSSCYLSTVQDDLVNIYKVISDNAMLSKWAGGIGNDWTAIRATGALIKGTNGKSQGVIPFIKVTNDTAVAVNQGGKRKGAVCVYLEVWHLDYEDFLELRKNTGDDRRRAHDVNTASWIPDLFFKRLQQKGSWTLFSPDDVPGLHDAYGEEFERLYEEYERKVDSGEIRLYKKVEAEDLWRKMLSMLFETGHPWMTFKDPSNIRSAQDHTGVVRCSNLCTEILLNCSETETAVCNLGSVNLVQHILDDGLDEEKLSETISIAVRMLDNVIDINFYPTKEAKEANFAHRAIGLGVMGFQDALYKLDISYASQEAVEFADYSSELISYYAIQASCLLAKERGTYSSYKGSKWDRGLLPIDTIQLLANYRGKDNLQMDTSVRKDWEPIRSLIREHGMRNCQLMAIAPTATISNIIGVTQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADMLDDLKYFDGSLLEIERVPDHIKHIFLTAFEIEPEWILECASRRQKWIDMGQSLNLYLAQPDGKKLSNMYLTAWKKGLKTTYYLRSSSATTVEKSFVDINKRGIQPRWMKNKSASAGIVVERASKTPVCSLEEGCEVCQ
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
What are the official names of this protein?
Ribonucleoside-diphosphate reductase subunit alpha, Ribonucleotide reductase.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
Protein: RS11_MAIZE
Sequence: MAEQTEKAFLKQPKVFLSSKKSGKGKKPGKGGNRFWKSIGLGFKTPREAIEGTYIDKKCPFTGTVSIRGRIIAGTCHSAKMNRTIIVRRNYLHFVKKYQRYEKRHSNIPAHISPCFRVKEGDHVIIGQCRPLSKTVRFNVVKVIPAGSAAAGKKAFTAA
What are the official names of this protein?
40S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_BRUME
Sequence: MRCPYCQSEDTQVKDSRPAEDGAVIRRRRVCSVCGGRFTTFERVQLRDLMVVKKSGRRVPFDRDKLTRSIEVALRKRDVDSERVERAISGIVRQLESAGEAEVTSDEIGRLAMDALKGIDDIAYIRFASVYRNFSKAVDFHNVIDELTVSETGDNLET
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: VM2_CROMR
Sequence: LRPGAQCADGLCCDQCRAGEECDCGSPANCCDAATCK
What is the function of this protein?
Inhibits ADP-induced platelet aggregation in human whole blood in a concentration-dependent manner (IC(50)=89. 5 nM).
What are the official names of this protein?
Disintegrin morulustatin.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.