PharMolix/UniProtQA huggingface dataset:
Protein: PTH_AKKM8
Sequence: MDAPVKMIVGLGNPGRTYEDTRHNAGFMVLDRLAARWGAVFKADRQRKCEVAAGPGVLLVKPSTFMNESGLCVGPMMRFFKLDPRSVFVIHDEVDFPLGVIKLREKGSAGGHNGIKSLIAHMGTQEFPRLRFGIGQPRGKGEMIGHVLGKFRPEERELLDVTLGKAEDAVLYTMEHGITRAGNIFNAVPG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_BRASB
Sequence: MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVTGPVEDGMATLIVAQLLFLEAENPKKEIAMYINSPGGVVTSGLAIYDTMQFIRPAVSTLCTGQAASMGSLLLCAGHKDMRFSLPNSRIMVHQPSGGFQGQATDIMLHAQEILSLKKRLNEIYVKHTGQSYKAIEDALERDKFLTAEAAAEFGLIDKVIDKRPEDPAPMAK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTC5_BOVIN
Sequence: MMAVEEEEVKEVLQKLQELVDQLYSFRECYFETHSVDDAGRKQQDVREEMEKTLQQMEEVVGSVQGNAQVLMLTGKALNVTPDYSPKAEELLSKAVKLEPKLVEAWNQLGEVYWKKGDVAAAHTCFSGALTHCKNKVSLQNLSMVLRQLRTDSGDEHSRHVMDSVRQAKLAVQMDILDGRSWYILGNAYLSLYFNTGQNPKISQQALSAYAQAEKVDRTASSNPDLHLNRATLHKYEENYGEALEGFSRAAALDPAWPEPWQREQQLLDFLTRLTSFLESKGKVKTKKLQSMLGNLRPAHLGPCGDGRYQSASGQKVTLERKPLNALQPGVNSGAVVLGKVVFSLTTEEKVPFTFGLVDSDGPCYAVMVYNMVQSWGVLIGDSVAIPEPNLRLHRIQHKGKDYSFSSVRVETPLLLVVNGKPQGSSSQAAATVASRPQCE
What is the function of this protein?
Cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation and DNA repair.  In physiological conditions, interacts with cofactor JMY in the cytoplasm which prevents JMY's actin nucleation activity and ability to activate the Arp2/3 complex.  Acts as a negative regulator of nutrient stress-induced autophagy by inhibiting JMY's interaction with MAP1LC3B, thereby preventing autophagosome formation (By similarity).  Involves in tubulin autoregulation by promoting its degradation in response to excess soluble tubulin.  To do so, associates with the active ribosome near the ribosome exit tunnel and with nascent tubulin polypeptides early during their translation, triggering tubulin mRNA-targeted degradation (By similarity).  Following DNA damage, phosphorylated by DNA damage responsive protein kinases ATM and CHEK2, leading to its nuclear accumulation and stability.  Nuclear TTC5/STRAP promotes the assembly of a stress-responsive p53/TP53 coactivator complex, which includes the coactivators JMY and p300, thereby increasing p53/TP53-dependent transcription and apoptosis.  Also recruits arginine methyltransferase PRMT5 to p53/TP53 when DNA is damaged, allowing PRMT5 to methylate p53/TP53.  In DNA stress conditions, also prevents p53/TP53 degradation by E3 ubiquitin ligase MDM2.  Upon heat-shock stress, forms a chromatin-associated complex with heat-shock factor 1 HSF1 and p300/EP300 to stimulate heat-shock-responsive transcription, thereby increasing cell survival.  Mitochondrial TTC5/STRAP interacts with ATP synthase subunit beta ATP5F1B which decreased ATP synthase activity and lowers mitochondrial ATP production, thereby regulating cellular respiration and mitochondrial-dependent apoptosis.  Mitochondrial TTC5/STRAP also regulates p53/TP53-mediated apoptosis (By similarity).
What are the official names of this protein?
Tetratricopeptide repeat protein 5, TPR repeat protein 5, Stress-responsive activator of p300, Protein Strap.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasmic vesicle. Mitochondrion matrix. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. Nuclear localization may be necessary for DNA damage- dependent stabilization of the protein.
Protein: ARAG1_BURCH
Sequence: MSAALRFDNIGKVFPGVRALDGISFDVHAGEVHGLMGENGAGKSTLLKILGGEYQPDAGSVLVDGRPVQFANAAASIAAGIAVIHQELQYVPDLTVAENLLLGRLPNAFGWVKKREAKRYVRERLAEMGVDLDPDARLGRLSIAQRQMVEICKALMRNARVIALDEPTSSLSHRETEVLFKLVDDLRAQGRALIYISHRMDEIYRLCDACTIFRDGRKIASHDALADVPRERLVAEMVGREIADIYHYAPRTLGDVRFSAEGVDGPALREPASFSVRAGEIVGFFGLVGAGRSELMRLVYGADRRRAGALTLDGKRIDVKRTGDAIRHGIVLCPEDRKEEGIIAIASVAENINISCRRHSLRAGLFINGKTESETADRFIQRLKIKTPNRRQKIRFLSGGNQQKAILSRWLAEPDLKVVILDEPTRGIDVGAKHEIYDVIYRLAERGCAIVMVSSELPEVLGVSDRIVVMREGRIAGELPRADANEHAVLNLALPQTSAVEAA
What is the function of this protein?
Part of the ABC transporter complex AraFGH involved in arabinose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Arabinose import ATP-binding protein AraG 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: COLD1_ORYSJ
Sequence: MGWGAVVYGGGVVGASLVGLGWAGLWFLNRRLYKEYEERRALVQILFGLVFAFSCNLFQLVLFEILPVLSKHARFLNWHLDLFCLILLLVFVLPYYHCYLLLRNSGVRRERALLVAALFLLVFLYGFWRMGIHFPMPSPEKGFFTMPQLVSRIGVIGVSVMAVLSGFGAVNLPYSYLSLFIREIDEKDIKTLERQLMQSMETCIAKKKKIVLSKMEMERIQGSEEKLKARSFLKRIVGTVVRSVQEDQTEQDIKSLDAEVQALEELSKQLFLEIYELRQAKIAAAFSRTWRGHAQNLLGYALSVYCVYKMLKSLQSVVFKEAGSVDPVTMTITIFLRHFDIGIDVTLLSQYISLIFIGMLVVISVRGFLANVMKFFFAVSRVGSGSTTNVVLFLSEIMGMYFISSILLIRKSLANEYRVIITDVLGGDIQFDFYHRWFDAIFVASAFLSLLLISAQYTSRQTDKHPID
What is the function of this protein?
Involved in chilling tolerance.  Interacts with the G-protein alpha subunit GPA1 to activate the calcium channel for sensing low temperature and to accelerate G-protein GTPase activity.
What are the official names of this protein?
GPCR-type G protein COLD1, Protein CHILLING TOLERANCE DIVERGENCE 1.
What is the protein family that this protein belongs to?
Belongs to the Golgi pH regulator (TC 1.A.38) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CH62_CUCMA
Sequence: MHRFASGLASKARLARKGANQIASRSSWSRNYAAKDVKFGVEARGLMLKGVEDLADAVKVTMGPKGRNVVIEQSYGAPKVTKDGVTVAKSIEFKDKVKNVGASLVKQVANATNDVAGDGTTCATILTRAIFTEGCKSVAAGMNAMDLRRGISMAVDSVVTNLKSRARMISTSEEIAQVGTISANGEREIGELIAKAMEKVGKEGVITISDGKTLFNELEVVEGMKLDRGYISPYFITNQKNQKCELDDPLILIHEKKISSINSVVKVLELALKRQRPLLIVSEDVESDALATLILNKLRAGIKVCAIKAPGFGENRKAGLHDLAVLTGGQLITEELGMNLEKVDLDMLGSCKKITISKDDTVILDGAGDKKSIEERCEQIRSAIELSTSDYDKEKLQERLAKLSGGVAVLKIGGASEAEVGEKKDRVTDALNATKAAVEEGIVPGGGVALLYASKELDKLSTANFDQKIGVQIIQNALKTPVHTIASNAGVEGAVVVGKLLEQDNPDLGYDAAKGEYVDMIKAGIIDPLKVIRTALVDAASVSSLMTTTEAIVVELPKDEKEVPAMGGGMGGMDY
What is the function of this protein?
Implicated in mitochondrial protein import and macromolecular assembly.  May facilitate the correct folding of imported proteins.  May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
What are the official names of this protein?
Chaperonin CPN60-2, mitochondrial, HSP60-2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NFI_DICTD
Sequence: MDWGREFFKWRGYEETVKLQEELSKKIILEDKFKELRYIGGVDTSSLGEKIVGIITILVFKTLELVEISVALSEVNFPYIPGFLSFREGPVILRAWEKLKIKPDLLIFDGQGIAHPRRLGIASHIGYVLDVPSIGCAKNILVGFYKEPDKRKGSFEYIYHKGEIVGAAVRTKDNVKPVFVSLGHKISLNTSIDIILKTSTKYRIPEPVRLAHLYSKRMLNSEIEGEPF
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_DESVH
Sequence: MNIASQIEDMGRRARAAGRRLAAASPAAKAGALDHLATLLEQRQDAILAANAADLAAAAEAGMDAPRMDRLRLTPATIAEMAAACRHVAALPDPVGAIETQWQRPNGLLVGKMRIPLGVIAMIYESRPNVTIDSAILCLKAGNAVILRGGSEAIHSNLALAALITEALSSVGLPAEAVQVVSTTDRAVIAELCKLEEHIDVIIPRGGETLIRAVVDMARMPVLKHYKGVCHAYIDSGADLAQAVEIIHNAKVQRPGVCNALEGLLVHRDEAAAFLPAIAERLGNDGVEFRACPASLPLLGDSAIPMKDEDNGQEFHDLILLVRIVDDMDEALAHIAAYGSNHTEIICTRDHGNAMRFLREADASMVAVNASSRFNDGGQLGLGAEIGISTSKLHSYGPMGVQELTTTKFVVFGAGQIRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANK_YERPP
Sequence: MGKGLALDIGGTKIAVAVVTESGMLIGRQQIATPRGGAGQLAAALETLIAPYRHQVDFIAVASTGIISGGRLTALNPANLGGLADFPLYDCIRSISDLPCVLLNDGQAAAWAEYQALGDKNDNMMFVTVSTGVGGGIILNKKLLVGQRGLAGHIGHTLSDPHGVLCGCGRRGCVESVASGTAIGAETLGWKQPVSAATVFDMAQQGDAQAGKVINRSAAAIAQMLADMKMALDLEVVILGGSVGLAVGYLERVVAAQKTLPGIYRVPVQEAHHRQDSGLLGAALWARTSL
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.
Protein: LEXA_SHIDS
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLQEEEEGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPNADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFKPIVVDLRQQSFTIEGLAVGVIRNGDWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: ADRC_PENRO
Sequence: MAPEEGDQAMSHEDKAACSSLNTTSSTELFDGAPSSENERLRIRQAAVDAMHHGSPKIDPQIWTDVTSHLSGSTTIDARQRDIFFENLTVHGKGSSLQIQKTVLSALLYPIAYPVKRLMSIVGNKKPHNDRRTILHGFNGILNSGELLLVLGRPGSGCSTFLKSLCGYLEGLDLDPVSEIQYRGVPFRVMIEKYRGDLVYNQEADHHFPNLTVGQTLEFAAHARAPHNQVGNSSRDQYVKSVVKVVMDTFGLSHTYDTNVGNDFVPGVSGGERKRVRTDTIVGMNSIAETVLSRTSIAAWDNSTRGLDAATAVDFVRSLRTSAKLAGSCHAVAVYQASEGLYNTFDKVILLYEGREIYFGPRQGAVAYFETMGWKRPPQQVSADFLTAITNPGERQPQVGMENAVPRTPVEFESYWKNSPEHAELETSMRQYKMKTPLDSSEEIKLDEIKRLEQSNHARISSPYLLSVPMQIRLCIVRAWQRTRNDIPALIATAVAQTVVSLIIGSLFYNIPENTAGLGQRASVLFLAVLTNALISLLEITTLYSQRLIVEKQAAYAFVHPFTEAIAEVIVDFPIKLFRCLLSAIIVYFLANLRREASHFFIYIMFQLTAVMTMATIFRTLATVTRTIGQAMALAGVVIICIAVYTGFTVPQFDMPPWFGWIRWLNPIFYTFEGIVSNEFHGRHFECVEYIPSLSFEQGLSFTCSYVGSIAGERYVSGDAYIAGSYDYSYDHVWRNYGILVAFLVFFYVLYFWLTELIPGTTPAHEVLIFRHGGVLQRLVRGDLERGESIRLQEVKSLASEVHSSKAEQKNTFSWKGLSYDIPVKGGEKRLLDDVSGWVKPGSLTALMGVSGAGKTTLMNVLARRMTIGVVTGDMFVNGRELDASFARNIGYVQQQDLHVETCTIREALRFSAALRQPQSVSMEEKYNFVEEVIQLLGMQNFAEAVIGSPGDGLNMEQRKLLSIGVELAAKPQLLIFLDEPTSGLDSRSSWAICAFMRKLADHGQPVLATIHQPSAVLFEQFDRLLFLAKGGRTVYFGDIGKQARTVLEYLEDKGARHCGPTENPAEYMLEVIGGGTQGQSTSIDWVQAWKRSTEYNKLLGELDILASSPSNGVSADPYMVGEFAMPLLVQFYHVMKRDLQQYYRQPEYILAKFGAGVFCGVFIGFSFWKSDNSSQGFQNVLFSLFLLCTIFSTLVNQIMPKFLSRRTLYELRERPARTYSWKVFILCQILVELPWQTLLGICTWASFYFSVYGSGQSSQRQGLVLLFTVQFFIFASTFAQLVVAAVPSVVLGSMLATFTFLLCLLFNGTMQPPSALPRFWIFMNRVSPLTYYVGGISATALHGRPIHCSNRELRVFDPPQGQNCGQYLAEYLKTAQGTLSNPLSTDQCQYCPLRVADQYLAARDISWDDRWRNFGIFWVYIIFNVIGAVLLYYLFRVLPYIRRNRTQKSRN
What is the function of this protein?
ABC-type transporter; part of the gene cluster that mediates the biosynthesis of the meroterpenoid compound andrastin A, a promising antitumoral compound (PubMed:28529508).  Is required for the production of andrastin A but does not have a significant role in its secretion (PubMed:28529508).
What are the official names of this protein?
ABC-type transporter adrC, Andrastin A biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NKX12_HUMAN
Sequence: MLAWQDGGAKAAPSHHKISFSVLDILDPQKFTRAALPAVRPAPREARKSLAEVEAGKDASSRDPVRQLETPDAAGPGAGQASPLEGSEAEEEEDAEDPRRPRLRERAARLLPGLARSPDAPAGALASGEPCEDGGGGPVRSPPGSPGSPRPRRRRLEPNCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAAQVGGGAPQPGAAGGGGGGGSGGSPGPPGTGALHFQTFPSYSAANVLFPSAASFPLTAAAPGSPFAPFLGPSYLTPFYAPRL
What is the function of this protein?
May function in cell specification, particularly in the CNS.
What are the official names of this protein?
NK1 transcription factor-related protein 2, Homeobox protein SAX-1, NKX-1.1.
What is the protein family that this protein belongs to?
Belongs to the NK-1 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ANGI_PAPHA
Sequence: MVMGLGLFLLVFMLGLGLTLPTLAQDNFRYRDFLAKHYDGTPEGRNDRYCESTMRRRHLTSPCKDTNTFIHGNRHHINAICGDENGNPYGGNLRISKSPFQVTTCKLHGGSPRPPCRYRATRGSRNIVVGCENGLPVHLDESIFRP
What is the function of this protein?
Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs).  Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus.  Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA.  Angiogenin induces vascularization of normal and malignant tissues.  Angiogenic activity is regulated by interaction with RNH1 in vivo.
What are the official names of this protein?
Angiogenin, Ribonuclease 5, RNase 5.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).
Protein: SURE_WOLPM
Sequence: MIILITNDDGFGSEGIKLLKEVARNFASEIWIVAPDTDRSGAARSLDYPVKQSIGIKQHSEREFSVSGTPADCVIIALNKVMNKKPDLILSGVNIGSNVGDDICYSGTIGAVMEGAARSIPSIALSQVYHDKIDWHNTKVFAPKVIAKLVKVGWPKNIVMSVNFPAKEKVKGVEFAEQGEYNIDGDLTFTENSNGSFSLNWSREHSGSGSINKIKEGFITITPVKLDFTDYDTLNTMKNSCADEFSSIAD
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HLH11_CAEEL
Sequence: MVRSDSAEEDQIIIDDGFDLTEEDEEMMSSGTGALPVTIADWNSVTNARMAPPSIMSAASAFDLTASGMQNSLRSVLPTSTIGHAPMLANRSLSQPAPLSPTSLDPDRRSRMRRQIANCNERRRMQSINAGFLALRALLPRKEGEKLSKAAILQQTADMVHQLLGHKGEDIPDGGEPKKLKLEEDHHDADHQAQIAHLQTILETERAARKALESQVIQLRELLQMTTTSSQASSPVTPRSNGSGGFTLPSSYASSALPTPLRESPERKPSFQDTTSTPLSLLTLNGSPTSSESLASQRIFHPPPTLPSLETTVIRPTPLPPISVEISSPSLSTPSPLTAAPIIFSTAVPTQSSILFQTAAAAVTSAMSTGNSTPVALPHHLQGHNSAFVSTQPSLTLSQSMQTIVEAIRHLEGSHFIPTSPPPTSQTSLVR
What is the function of this protein?
Transcriptional regulator (PubMed:33078707).  Component of a feedback loop involving atfs-1, atgl-1 and hlh-11 (PubMed:33078707).  Binds to the promoter of the atgl-1 lipase to negatively regulate the expression of atgl-1, and thereby promoting fat oxidation in response to mitochondrial stress and mitochondrial respiration in the intestine (PubMed:33078707).  In addition, functions with atfs-1 to maintain lifespan (PubMed:33078707).  May have a role in fertility and in positively regulating body size (PubMed:19855932).
What are the official names of this protein?
Helix-loop-helix protein 11.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIMO_ANADF
Sequence: MATTRVYLHTLGCPKNRVDSEVMLGTLTGAGYRLERDPAQADVIVVNTCGFIESAKEESVDAIVELAGMKQEGRCKKLVVTGCLVQRHAEELSAELPEVDHFLGTGAYAEIARVVSDAQAKRLVVPDPDFVHSAATPRVNSLPSHTAYLKISEGCDNACAFCIIPKLRGAQRSRPVDDVVAEAAALAAQGTVELSLVAQDLTAYGYDLPGKVRLHHLLPELCKVDGIRWLRLHYAYPRDVPDALVEVIAREPKIVKYLDMPLQHSSDRLLRSMKRGRDSVFLRELLARLRARVPGIALRTSLIVGLPGETEEDFEDLVRFVEEQRFERLGVFEFSPEDGTPAADMAEQVPDVVKRARRDRIMALQQEISREHQRAMVGRRLEVLVEGRAEETEHLLAGRHAQQAPEIDGITYVNDGVAYPGELVTVEITDASEYDLVGHVVARDPERARRPLPAPAGGETPRRGGLPVVG
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_HALOH
Sequence: MVILGVDPGLAIVGYALIEKQGNKYRVIDYGSINTPSKLESVDRLKIIHTDMVNIINKYNPDQMAVEKLFFNKNVKTAIEVGQARGVILLAGSQARLKIYEYTPLQVKQAVAGYGRAHKSQVQRMVKALLNLNEIPKPDDVADALAISICHGNSYRLNRKWGTKG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: COX2_WICCA
Sequence: MLLIINNIINNDVPTPWGVYFQDSATPNHEGIIELHDNIMFYLVLILCLVSWLLFSIVKDGSKNPLPHKYLVHGQTIEIIWTILPALVLLVIAFPSFILLYLCDEVISPAMTIKAIGLQWYWKYEYSDFINDSGETIEFESYVIPEDLLEDGQLPLLDTDTSIVCPVNTHIRFIVSAADVIHDFAVPSLGIKIDACPGRLNQVSALIQREGVYYGQCSELCGVAHSAMPIKVEAVSLKEFLTWLNEQ
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DER_PARP8
Sequence: MKPVIALVGRPNVGKSTLFNRLTRSRDALVADLPGLTRDRHYGEGRVGGERPYLVVDTGGFEPVAKDGILFEMARQTRQAVEESDVIVFIVDGRNGLAPQDKSIADYLRKTGRPIFLVVNKAEGMKYTNVAADFYELGLGDPRAISAAHGDGVTEMINEALDVAYAGQPEESDEEKAQHGIKIAIVGRPNVGKSTLVNTLIGEDRVIAFDMPGTTRDSIYVDFERQGKKYTLIDTAGLRKRGKVFEAIEKFSVVKTLQSISDANVVILLLDARQDISEQDAHIAGFVVEQGRALVVGVNKWDGLDPHVRERTKSDLQRKLKFLEFAKFHFISAAEKTGIGPLMRSVDDAYKAAMSKLPTPKLTRALIEAVEFQQPRRRGPVRPKLRYAHQGGQNPPIIVIHGNALDAVTDTYKRYLENRFRETFALTGTPLRIEFRSSTNPYADKD
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PON1C_ANOEM
Sequence: RSVCSNGCRPKPFGGCSC
What are the official names of this protein?
U1-poneritoxin-Ae1c, U1-PONTX-Ae1c, Poneratoxin.
What is the protein family that this protein belongs to?
Belongs to the poneritoxin-Ae1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR7_YERPN
Sequence: MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMTKLEEAGIPTQMERLLSDTEVLVKKLEMIPVECVIRNRAAGSLVKRLGIEEGLSLNPPLFDLFLKNDAMHDPMVNESYCKTFGWATEAQLARMKELSYLANDVLSKLFDDAGLILVDFKLEFGLFNGEVVLGDEFSPDGSRLWDKKTLNKMDKDRYRQSLGGLIEAYEEVAHRIGVKLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: TMBI4_CAEEL
Sequence: MATINSHLREPERVNLLSDHDDSDDDEVHVKRNPQMWPMSMASSAHAEAGIVDADGILPGCVGKANRMIRIAFLRKVLGIVGFQLLFTIGICAAIYNIPNSNQLLQKHAWIVFPNLLGSIALIIALHVYAREVPLNYVLLAAFTAVQAVTMGCVVTLFEAKVVLEAAVITGLVVASLFAYTLQNKRDFSVGYASMGSLLCVLLWAGIFQMFFMSPAVNFVINVFGAGLFCVLLVIDLDMIMYRFSPEDYICACVSLYMDILNLFIRILQIVAEANK
What are the official names of this protein?
Transmembrane BAX inhibitor motif-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the BI1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FLAB3_BRAHO
Sequence: MIINNNISALNANRQLNLTGNSMTK
What is the function of this protein?
Component of the core of the flagella.
What are the official names of this protein?
Flagellar filament core protein flaB3, 32 kDa core protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Periplasmic flagellum. Periplasm.
Protein: UGPC_BURCM
Sequence: MAALSLKGIRKSYDGKQHVLHGIDVEIADGEFVVLVGPSGCGKSTLLRMIAGLETVTDGEIAIGDRVVNALEPKDRDIAMVFQNYALYPHMTVAQNMGYGLKIRGIERATIDSRVAAAAKILELEPLLARRPRELSGGQRQRVAMGRAIVREPSVFLFDEPLSNLDAKLRVQMRLEIQRLHARLATTSVYVTHDQIEAMTLAQRVIVMNRGYAEQIGAPVDVYEKPETVFVAGFIGSPAMNLMHGRLSEDGATFAVAGGGPALPVAGAPGIGTTIATGRDWVLGVRPEHMTPQPGVAQASLPVDSCELLGADNLAHGRWGNHDVVVRLPHADRPARGTALGAALPAHRLHFFDPETGKRAG
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
sn-glycerol-3-phosphate import ATP-binding protein UgpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.