PharMolix/UniProtQA huggingface dataset:
Protein: MAP1_MYCGE
Sequence: MIYLKSANEVAGIKKACAIFKAVKAYFTIEKLLGKKLVTIDRLIKQFIEQKQAKCAFHGYLGFPGFNCLSLNQTVIHGVADQTVFKDSDKLTLDIGIDYHGYLCDAAFTLLGNKADPKAVKLLNDVEQAFSKVIEPELFVNNPIGNLSNAIQTYFENKGYFLVKEFGGHGCGIKIHEDPLILNWGEKNQGVRLQEGMVICIEPMVMTDSSEITMAANNWNVLTLKSKFNCHVEQMYHITNNGFECLTN
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).  Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Protein: CYB_ZAGBR
Sequence: MHNPRKTHPLIKIVNHTFIDLPTPSNISSWWNFGSLLGMCLIIQILTGLFLAMHYTADTTTAFSSVAHICRDVNYGWLIRYLHANGASLFFICIFLHIGRGLYYGSYMNTETWNIGVLLLFTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFVVAALTIIHLLFLHETGSNNPSGLNSDSDKIPFHPYYSIKDLLGFFIATLVLMLLVLFTPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVASIMILALIPMLHTSCQRGLTFRPLTQTLFWILVTNLLTLTWIGGQPVEQPFIIIGQLASILYFLLITTFIPLAGLLENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y965_XYLFM
Sequence: MESPMHLPEVIAVEQESQQMGLSVTAPELHGSLSGLLAGGGCNGPDWLAMILADAEVAAPPKGSVLERLYQATASQLEDPDFAFQLLLADDGATLAARADALFEWCRAFLGGFGLAAHSRSVLSAEGDEILRDLAKLAQASVDDFDMNEDKEDGSLEEIEEYVRVAVLLLHGDCLIGPCAPQRLN
What are the official names of this protein?
UPF0149 protein Xfasm12_0965.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: ISDA_STAAE
Sequence: MTKHYLNSKYQSEQRSSAMKKITMGTASIILGSLVYIGADSQQVNAATEATNATNNQSTQVSQATSQPINFQVQKDGSSEKSHMDDYMQHPGKVIKQNNKYYFQTVLNNASFWKEYKFYNANNQELATTVVNDNKKADTRTINVAVEPGYKSLTTKVHIVVPQINYNHRYTTHLEFEKAIPTLADAAKPNNVKPVQPKPAQPKTPTEQTKPVQPKVEKVKPTVTTTSKVEDNHSTKVVSTDTTKDQTKTQTAHTVKTAQTAQEQNKVQTPVKDVATAKSESNNQAVSDNKSQQTNKVTKHNETPKQASKAKELPKTGLTSVDNFISTVAFATLALLGSLSLLLFKRKESK
What is the function of this protein?
Cell wall-anchored surface receptor that participates in the extraction of heme from oxidized methemoglobin/metHb to enable growth on hemoglobin as a sole iron source (PubMed:17229211, PubMed:12574635).  Receives heme from IsdB and transfers it to IsdC (By similarity).  Plays also a role in the inhibition of host immune response (PubMed:18097052, PubMed:18005699, PubMed:18227165).  Protects S. aureus against the bactericidal protease activity of apolactoferrin (PubMed:18097052).  Decreases bacterial cellular hydrophobicity, which renders S. aureus resistant to bactericidal human skin fatty acids as well as to beta-defensins and cathelicidin (PubMed:18005699).  Also binds fibronectin and chains B-beta and gamma of fibrinogen, promoting clumping of S. aureus with fibrinogen.  Involved in adherence of S. aureus to human desquamated nasal epithelial cells and is required for nasal colonization.
What are the official names of this protein?
Iron-regulated surface determinant protein A, Fur-regulated protein A, Staphylococcal transferrin-binding protein A.
What is the protein family that this protein belongs to?
Belongs to the IsdA family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Encodes an LPXTG motif-containing sorting signal that targets to the cell wall, which is catalyzed by sortase A.
Protein: SPC3_SCHPO
Sequence: MIVDTFTNRGSTFFSKLSTVLFFLCAVITFQGVIQRREVELDTPVYVHYAKYRSARFYHAFRNVRQQYAQVKFNMDADLSELWDWNTKHVVVYLVASYSTEKHEKNQVVVWDKILSSPEESKMFMKDTLSNIQAHPFNEYSNQFEGKNATYTLHWTVSPKMGFLSWGAGPGSYEIPFHKIITQPK
What is the function of this protein?
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.  Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.  Essential for viability.
What are the official names of this protein?
Signal peptidase complex subunit 3, Microsomal signal peptidase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the SPCS3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: PLSX_NEIMA
Sequence: MITLAVDAMGGDQGLAVTVPGATAFLQAHPDVHLIMTGDETQLRQALTAAGAPMERIDICHTAQIVGMDEAPQSALKNKKDSSMRVAVNQVKEGKAQAAVSAGNTGALMATARFVLKTIPGIERPAIAKFLPSDTDHVTLALDLGANVDCTPEQLAQFAVIGSELVHALHPQKGQPRVGLVNVGTEDIKGTDTVKQTYKLLQNSKLNFIGNIESNSILYGEADVVVADGFVGNVMLKTIEGAVKFMSGAIRREFQSNLFNKLAAVAALPALKGLKNKLDPRKFNGAILLGLRGIVIKSHGGTDETGFRYALEEAYHEAKSASLSKIEQGVAEQLAALETAKAVQNENVGGL
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: PCFT_MOUSE
Sequence: MEGRVSSVGSPHSFLNAPVLFRGPVEPLVFLANFALVLQGPLTTQYLWHRFSTELGYNGTRHRENCGNQSADPLMKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLELHVGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALALLIVMALYAAFCFGETVKEPKSTRLFTLRHHRSIARLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSAPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSIYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHPEFQQFPQSP
What is the function of this protein?
Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:17962486).  Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:17962486).  Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity).  Protonation of residues in the outward open state primes the protein for transport (By similarity).  Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity).  Also able to transport antifolate drugs, such as methotrexate and pemetrexed (PubMed:17962486).  Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (By similarity).  Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (PubMed:16143108).  Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (PubMed:22058337).  Hence, participates in the trafficking of heme and increases intracellular iron content (By similarity).
What are the official names of this protein?
Proton-coupled folate transporter, Heme carrier protein 1, PCFT/HCP1, Solute carrier family 46 member 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SLC46A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cytoplasm. Note=Shifts from the apical membrane of intestinal cells iron-deficient cells to the cytoplasm in response to increased in iron stores (PubMed:16143108). Localizes to the basolateral membrane of choroid plexus (PubMed:19074442).
Protein: 3MGH_EHRRW
Sequence: MYNILKKSFYKQKSLDVASSLLGKMLLFNQHKGIITETEAYIGQDDQAAHSFHGYTKRTAVMFGNPGFSYVYLIYGMYHCLNVVTEPEGFPAAILIRSIILLSKNTPHTKVNGPGKICKILDITKEHNNIDMTANHSFCICDTNLNIDDYICTPRIGISKATDKFWRFVIPDVTSLQYIDTKLVPTLT
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: G6PI_STRPC
Sequence: MSHITFDYSKVLESFAGQHEIDFLQGQVTEADKLLREGTGPGSDFLGWLDLPENYDKEEFARILTAAEKIKSDSEVLVVIGIGGSYLGAKAAIDFLNHHFANLQTAKERKAPQILYAGNSISSTYLADLVEYVQDKEFSVNVISKSGTTTEPAIAFRVFKELLVKKYGQEEANKRIYATTDKVKGAVKVEADANNWETFVVPDNVGGRFSVLTAVGLLPIAASGADITALMEGANAARKDLSSDKISENIAYQYAAVRNVLYRKGYITEILANYEPSLQYFGEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGYRNLFETVIRVDKPRKNVIIPELAEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGGVPNMFVTLPAQDEFTLGYTIYFFELAIAVSGYMNAVNPFDQPGVEAYKRNMFALLGKPGFEALSAELNARL
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGRA_STAAR
Sequence: MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDPVGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI
What is the function of this protein?
Required for high-level post-exponential phase expression of a series of secreted proteins.
What are the official names of this protein?
Accessory gene regulator protein A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE1_ECO57
Sequence: MMSNISRQAYADMFGPTTGDKIRLADTELWIEVEDDLTTYGEEVKFGGGKVIRDGMGQGQMLSAGCADLVLTNALIIDYWGIVKADIGVKDGRIFAIGKAGNPDIQPNVTIPIGVSTEIIAAEGRIVTAGGVDTHIHWICPQQAEEALTSGITTMIGGGTGPTAGSNATTCTPGPWYIYQMLQAADSLPVNIGLLGKGNCSNPDALREQVAAGVIGLKIHEDWGATPAVINCALTVADEMDVQVALHSDTLNESGFVEDTLTAIGGRTIHTFHTEGAGGGHAPDIITACAHPNILPSSTNPTLPYTVNTIDEHLDMLMVCHHLDPDIAEDVAFAESRIRQETIAAEDVLHDLGAFSLTSSDSQAMGRVGEVVLRTWQVAHRMKVQRGPLPEESGDNDNVRVKRYIAKYTINPALTHGIAHEVGSIEVGKLADLVLWSPAFFGVKPATIVKGGMIAMAPMGDINGSIPTPQPVHYRPMFAALGSARHRCRVTFLSQAAAANGVAEQLNLHSTTAVVKGCRTVQKADMRHNSLLPDITVDSQTYEVRINGELITSEPADILPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNS2_PYRPY
Sequence: MIYIFTMVFSLNVLILSSSAARYDYFQFTQQYQQAFCNSNPTPCKDPPDKLFTVHGLWPSTKVGRDPEYCKTKRYRKIQRLEPQLEIIWPNVSDRKANRGFWRKQWYKHGSCASPALPNQKHYFETVIRMFLAEKQNVSRILSMATIEPEGKNRTLLEIQNAIRAGTNNMIPKLKCQKVNGMTELVEVTLCHDSNLTQFINCPRPLPQASPYFCPIDDIQY
What is the function of this protein?
Self-incompatibility (SI) is the inherited ability of a flowering plant to prevent self-fertilization by discriminating between self and non-self pollen during pollination.  In many species, self-incompatibility is controlled by the single, multiallelic locus S.
What are the official names of this protein?
Ribonuclease S-2, S2-RNase.
What is the protein family that this protein belongs to?
Belongs to the RNase T2 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: CP26B_XENTR
Sequence: MIFQSFDLVSALATLAACLVSVALLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLVGETFHWILQGSDFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNSLANSIGDIHRHKRKVFSKIFSHEALESYLPKIQLVIQDTLRVWSSNPESINVYCEAQKLTFRMAIRVLLGFRLSDEELSQLFQVFQQFVENVFSLPVDVPFSGYRRGIRAREMLLKSLEKAIQEKLQNTQGKDYADALDILIESGKEHGKELTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPSVLEKLREELRGNSILHNGCVCEGALRVETISSLHYLDCVIKEILRLFSPVSGGYRTVLQTFELDGFQIPKGWSVLYSIRDTHDTAPVFKDVDVFDPDRFGQDRTEDKDGRFHYLPFGGGVRNCLGKHLAKLFLKVLAIELASMSRFELATRTFPKIMPVPVVHPADELKVRFFGLDSNQNEIMTETEAMLGATV
What is the function of this protein?
Plays a key role in retinoic acid metabolism.  Appears to be involved in the inactivation of all-trans-retinoic acid (RA).
What are the official names of this protein?
Cytochrome P450 26B1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: RECA_XANOP
Sequence: MDENKKRALAAALSQIEKQFGKGSVMRMGDRVIEAVEVIPTGSLMLDIALGTGGLPKGRVVEIYGPESSGKTTLTLQAIAQCQKLGGTAAFIDAEHALDPVYAAKLGVNVDDLLLSQPDTGEQALEIADMLVRSSSVDIVVIDSVAALTPKAEIEGEMGDQLPGLQARLMSQALRKLTGNIKRSNTLVVFINQLRMKIGVMMPGQSPEVTTGGNALKFYASVRLDIRRIGAIKKGDEIIGNQTKIKVVKNKLAPPFKQVVTEILYGEGISREGELIDMGVEAKLVEKAGAWYSYGDERIGQGKDNARTYLRDNPQVAVRLEAELREKFQPAEAPREAGDDEEKE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTCA_METBU
Sequence: MIDIDGSYGEGGGQIVRNAIALSAVTGKATSIKNIRKDRPNPGLSAQHVKAIGIAALLCDAKVEGIKIGSTNIAFFPQEIRGGKYTIDIGTAGSIALLLQCIMPIATYSNTNIKLEIKGGTDVSWAPSIDYLKNVTLSALSKMGYRCNIDILKRGYYPRGGGIVNAIIEPSHLVPDRFSEERGTIRGISHCSNLPEHVAQRQADKAKAILENAGHECSIETCRTDFTSTGSGITLYCGMKGSFVPGKRGTTAEKVGNDAATSLLDELLTPSSVDIHLADQLIPYLGLAEGGSFTVKEISPHTKTNIWVTEKFLDVKFKIEKRNDIVKISIQ
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBK_LEPBU
Sequence: MFLFNLEQSIGLLPEAYLPFDPLVDVLPIIPLLFLLLAFVWQAAVKFR
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein K, PSII-K.
What is the protein family that this protein belongs to?
Belongs to the PsbK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y624_MARMS
Sequence: MSIKHWPEQERPREKLIQQGAGALSDSELLAIFLRTGTQGISAVELARQLLAQFGGLRSLMSASREEFCQGLGLGDAKYTQLQAVLEMSKRHLQEQLMRETVFASAEHVRTYLSSQLRHSPREVFAVLFLDTQHRLIRYQELFMGTIDAAAVYPREVVKAALQYNAAAVILAHNHPSGIAEPSQADISITDKIKRALDLVDVRLLDHFVVGDGLPVSLAERGLV
What are the official names of this protein?
UPF0758 protein Mmwyl1_0624.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: GBP1_PONAB
Sequence: MASEIHMTGPMCLIESTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
What is the function of this protein?
Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens.  Hydrolyzes GTP to GMP in two consecutive cleavage reactions: GTP is first hydrolyzed to GDP and then to GMP in a processive manner.  Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and promotes both autophagy and inflammasome assembly (By similarity).  Promotes host defense against bacterial infections by regulating bacteriolytic peptide generation via its interaction with ubiquitin-binding protein SQSTM1, which delivers monoubiquitinated proteins to autolysosomes for the generation of bacteriolytic peptides (By similarity).  Also acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria.  Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol.  Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity).  Confers protection to several pathogens, including the bacterial pathogens L. monocytogenes and M. bovis BCG as well as the protozoan pathogen T. gondii (By similarity).  Exhibits antiviral activity against influenza virus (By similarity).
What are the official names of this protein?
Guanylate-binding protein 1, GTP-binding protein 1, GBP-1, Guanine nucleotide-binding protein 1, Interferon-induced guanylate-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cell membrane. Secreted. Cytoplasmic vesicle. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor (By similarity).
Protein: YIDD_PROMH
Sequence: MASSLSLGSKILILLIRGYQLGISPLLGPRCRFNPTCSHYGIEALRRFGMIKGSWLTVKRILKCHPLHEGGDDPVPPRKNDDNREN
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL25_NOCFA
Sequence: MSDANLLEASVRTEFGKGAARRTRRAGNVPAVLYGHQSEPQHLSLNAQAFAAILREHGTNAVLNLDIEGKKQLALTKSVVVHPIRRYIEHADLLIVKRGEKVTADVAVTVTGDAAPGTLVTQEATTISIEAEALNLPEAIEVSVEDAEIGTQITAGSIALPQGVTLASDPELLVVNVIAAPAAEPAPGEEAAEAEGESAE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: ATPG_SHEPC
Sequence: MAGAKEIKTKIASVKNTQKITSAMEMVAASKMRRAQERMAASRPYAESMRKVIGHVAQGSLEYKHPYLEVREAKRVGYIVVATDRGLCGGLNVNLFKKVLLDLKNWKEQGAEVEFCPIGARSVQFFKSFGGTMPAHASGLGDAPSIADLIGTVRVMLKAYNEGKLDRLFIVFNKFVNTMTQAPVIEQLLPLPKSEEVANKHPWDYIYEPDPKVLLDTLLVRYIESQVYQGVVENIASEQAARMVAMKAATDNAGELINDLQLVYNKARQAAITQELSEIVSGASAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PETN_ATRBE
Sequence: MDIVSLAWAALMVVFTFSLSLVVWGRSGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: AGLA_THENE
Sequence: MPAVKIGIIGAGSAVFSLRLVSDLCKTPGLSGSTVTLMDIDEERLDAVLTIAKKYVEEVGADLKFEKTTSVDEAIADADFVINTAMVGGHTYLEKVRRISEKYGYYRGIDAQEFNMVSDYYTFSNYNQLKYFVDIARKIERLSPKAWYSAAANPVFEGTTLVTRTVPIKAVGFCHGHYGVMEIIEKLGLERKQVDWQVAGVNHGIWLNRFRYNGEDAYPLLPRWISEKSKDWKPENPFNDQLSPAAIDMYKFYGVMPIGDTVRNASWRYHRDLETKKRWYGEPWGGADSEIGWKWYQDTLGKVTDITKKVAKFIKENPALKLSDLGSVLGKDLSEKQFVLEVEKILDPEKKSGEQHISFHDALLNDNRSRFVINIPNKGIIQGIDDDVVVEVPAVVDRDGIHPEKIDPPLPERVVKYYLRPRIMRMEMALEAFLTGDIRIIKEVLYRDPRTKSDEQVEKVIEEILSLPENEEMRKNYLKK
What is the function of this protein?
Is able to hydrolyze diverse types of alpha-glycoside bonds in di- and trisaccharides: alpha-1,4 bonds of maltose and maltotriose, alpha-1,1 bonds of trehalose, alpha-1,2 bonds of sucrose, alpha-1,3 bonds of turanose and melizitose, alpha-1,6 bonds of isomaltose and melibiose.  AglA is not specific with respect to the configuration at the C-4 position of its substrates because it also possesses alpha-galactosidase activity.  Acts on the substrate from the non-reducing end of the chain.  The activity of AglA drops with increasing length of the saccharide chain.  Does not hydrolyze alpha-, beta-, and gamma-cyclodextrins or polysaccharides (starch, pullulan, amylose, amylopectin, glycogen).  Does not cleave beta-glycosidic bonds in di-, oligo-, or polysaccharides.
What are the official names of this protein?
Alpha-glucosidase, Maltase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 4 family.