PharMolix/UniProtQA huggingface dataset:
Protein: HIS3_CUTAK
Sequence: MRRVQTEEPTLAPAIAARLRRNDAGLVPAVVQDAATGDVLMMAWMDDVALARTLATRRATYWSRSRQEYWVKGETSGHTQHVCSVRLDCDGDTLLLRVDQVDGACHTGDHTCFDADVLLAEEVES
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1574_ERWT9
Sequence: MSENCPCGSELQYSVCCGPYLRGGAYPDTPEALMRSRYCAYAQQNLPYLIASWHPSCNAQNFAASLEESFSNTRWHGLRVISTEVLSDQDTGYVTFFARFSENKQQSFLHERSRFLREEQRWYYIDGTFPPTGRNDRCPCGSGKKYKKCCGQH
What are the official names of this protein?
UPF0225 protein ETA_15740.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: UREG_RALSO
Sequence: MRTKKLPALRVGVGGPVGSGKTTLLEMLCKAMRERYDLVAITNDIYTKEDQRLLTLSGALPAERIMGVETGGCPHTAIREDASINLEAVDRMLARFPDADVVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLIINKTDLAPYVGASLDVMASDARKMRGDRPFVMCNLKEQAGLDAVVRFIEQQGMLAAPAAG
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBM18_DANRE
Sequence: MQSAAETVENASILSGGSAQDGHRLWIGNIDPKITEYHLVKLLEKFGKVKQFDFLFHKSGPLEGQPRGYCFVNFHTKEEAERAIQCLNGKLALSKKLVVRWAHAQRFEPFRGEKNMPASLEPSSSEAEDLPTSLSVNAKIRAIEAKLQMMEENPDDYSGPSAYTYNKPPDKREKRSQPYHKHFRKHRR
What are the official names of this protein?
Probable RNA-binding protein 18, RNA-binding motif protein 18.
Protein: RAP94_VACCW
Sequence: MDSKETILIEIIPKIKAYLLDANISPKSYDDFISRNKNIFVINLYNVSTITEEDIRLLYTTIEQNIDADDQTLVAIFSYIGYKFEQAVKEEISTSLSFNDKNTTDEMTYNLYDLFFNTLDMYLRQKKISILVNDDVRGDVIVSYKNSDLVSSFNAELEPEIKKIPFNMKNLLPYLEKNLDQLRFSKKYLDFAYLCRHIGIPISKKKYNVRYVFLYKIDGLSIPIIIKDFLDVKYVYLENTGKIYKNSFSEDHNNSLSDWGKVIIPLLKDRHLYSYIFLSSYHLHSYYTDLIARDEPVFVKRKKLDIIEIDEPEAWKRDVRVEFAPCEHQIRLKEAMKVDANYFTKINNFANEFIYYEDGVAYCRVCGINIPIFNLDAADVIKNTVIVSTFNKTIFLSEPYSYFVHSQRFIFNIIMSFDNIMKSQTWVMKYNINRLILNFLIDINSRRQEYEKKFSSEIKRGLFFLRLSANLFESQVSSTELFYVSKMLNLNYIVALVIILNSSADFIVSYMTSKNKTVEESTLKYAISVVIYDFLVKTRICEKGSLDTIVLFTDVYTSIMPEELDLHFQRITLELRKLVSIQRSALEPNYDVESRGEELPLSALKFFDTSTIIVKTMAPVHTYIEQKIVAPTPSVEPTDASLKNFKELTCDEDIKILIRVHDTNATKLVIFPSHLKIEIERKKLIIPLKSLYITNTLKYYYSNSYLYVFRFGDPMPFEEELIDHEHVQYKINCYNILRYHLLPDSDVFVYFSNSLNREALEYAFYIFLSKYVNVKQWIDENITRIKELYMINFNN
What is the function of this protein?
DNA-directed RNA polymerase-associated factor required for the transcription of viral early genes as well as for transcription termination.  Within minutes after virus entry, recruits the core RNA polymerase, the early transcription factor (ETF) and other enzymes needed for transcription initiation, elongation, and termination thereby allowing synthesis of early mRNAs which are extruded through pores in the core particle.  Recruits the multifunctional OPG102 protein, with poly(A) polymerase-stimulatory, cap nucleoside-2'-O-methyltransferase, and transcription elongation activities.  Interacts with nucleoside triphosphatase I/OPG123, a DNA-dependent ATPase required for the termination of early transcripts.  Acts as a transcription termination factor by binding, together with the capping enzyme/VTF, to the termination motif 5'-UUUUUNU-3' in the nascent mRNA.  Involved as well in the packaging of RNA polymerase and other components needed for early transcription in assembling virus particles.
What are the official names of this protein?
RNA polymerase-associated transcription-specificity factor RAP94, Protein H4, RPO-associated protein of 94 kDa.
What is the protein family that this protein belongs to?
Belongs to the poxviridae protein RAP94 family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome.
Protein: YHE1_YEAST
Sequence: MHLYSIAKSTTILRFLRHILLPFLHLSIHFTSCLCRIIYVGWKSFWKHFFFCGHKIKTPLFIASYAMFLAKQKIIVTMFEVSSVLEKLPQNILLFHYPLPSKMGNNLLMSFLTQRSIDEKEIDALLHPNAVYRFCNMRTTFRTLSSYGK
What are the official names of this protein?
Uncharacterized protein YHL041W.
Protein: TXX1A_ETHRU
Sequence: MASQVVLSFALVVVLAVFVGQVDSCPSDCKCDYRSSQCRPANDDVHPNVCIDHYCVVMNLAKREQRPELSPGAWDDSSEEKDNEASLA
What are the official names of this protein?
U-scoloptoxin(XY)-Er1a, U-SLPTX(XY)-Er1a, U-scoloptoxin-Er4.1a2a, U-SLPTX-Er4.1a2a.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-XY family.
What are the subcellular locations of this protein?
Secreted. Note=The mature toxins are clearly liberated from the multidomain precursors in the venom gland prior to venom expulsion and not by venom proteases upon secretion.
Protein: RL30_CLOD6
Sequence: MAKLQIKLVRSVIGTTPNQKKNVEALGLRKREQVVVKEDNAQTRGMINKVSHLLEVTEIAE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: MASZ_MYCUA
Sequence: MTDRVSAGNLRVARVLYDFVNNEALPGTDIDQDSFWAGVDKVVTDLTPQNQDLLKTRDDLQAQIDKWHRHRVIEPLDPQAYREFLTEIGYLLPAPEDFTITTSGVDDEITTTAGPQLVVPILNARFALNAANARWGSLYDALYGTDVISESDGAEKGRGYNKVRGDKVIAYARQFLDDSVPLAGASYTDATGFKVEDGQLVVSLADTSAALADPGQFAGYTGTAENPKSILLANHGLHIEILIDPESQIGATDGAGVKDVILESAITTIMDFEDSVAAVDADDKALGYRNWLGLNRGDLSEDVTKDDKTFTRVLNTDRTYTAPHGGELTLPGRSLLFVRNVGHLMTNDAIVSDAEGAEGAPVFEGIMDALFTGLIAIHGLRSTDANGLLTNSRTGSIYIVKPKMHGPAEVAFTCELFSRVEDVLGLPQGTMKVGIMDEERRTTLNLKACIKAAADRVVFINTGFLDRTGDEIHTSMEAGPMIRKGAMKNTAWIKAYEDANVDTGLAAGFSGKAQIGKGMWAMTELMADMVEQKIAQPKAGATTAWVPSPTAATLHAMHYHKVDVFAVQKELQGKTRTSVDELLTIPLAKELAWAPEEIREEVDNNCQSILGYVVRWIDQGVGCSKVPDIHNVALMEDRATLRISSQLLANWLRHGVITSEDVRASLERMAPLVDKQNAGDPEYHAMAPNFDDSIAFLAAQDLILSGAQQPNGYTEPILHRRRRELKARAGA
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_CALS4
Sequence: MEERTFEMELAGRKLVVQTGKVAQQANGAAWVKYGDTVVLVTACASKEPREGIDFFPLTVEYEERLYSIGKIPGGFIKREGKPSEKAILSARLIDRPIRPLFPEGYRNDVQVIATVLSVDPDAQPEIVAMIGSSVALSISDIPFNGPTGSVAVGLVDGKFVINPTYEQREKSLMHLVVSGTKDAIVMVEAGAKEVPEETILDAIVYAHQYIKQIVEFIEGIVKEVGVPKAEVVLHEIDKELEEKVRAYATEKIYNALRTPEKKERNDNLDKVEQEVLEHFKDEYPDNLADIDEVLYKIMKEQMRKMIKEEKIRVDGRGLDDIRPIWCEVGVLPRTHGSAIFTRGQTQVLTVATLGAIGDIQILEGIGDEEFKRYMHHYNFPPYSVGEVRPLRGPGRREIGHGALAERALEPVIPSEEEFPYTIRLVSEVLSSNGSTSQASVCGSTLALMDAGVPIKAPVAGIAMGLIKEEDEVLILTDIQGIEDFLGDMDFKVAGTEKGVTAIQMDIKIPGIDRDILQMALEKARKARLYVLQKMLEVIKEPRKELSKYAPRVVRMVVNPEKIRDIIGPAGKTITKIISETGVKIDIEEDGRLYITAPNLEAGERAKQMIEAITKDIEVGGIYLGKVLRIAPFGAFVEIAPGKEGLVHISNLSKKRVRRVEDVVKVGDNILVKVTEIDKLGRIVLSRKDAMPDEEESDNRKSDNRKK
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_STRT1
Sequence: MVDVNRFKSMQITLASPTKVRSWSYGEVKKPETINYRTLKPEREGLFDEVIFGPTKDWECACGKYKRIRYKGIVCDRCGVEVTRAKVRRERMGHIELKAPVSHIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKETPLERKSLLTEREYREKLQEYGQGSFVAKMGAEAIQDLLKQVDLEAEIAELKEELKTATGQKRFKAVRRLDVLDAFYKSGNKPEWMVLNILPVLPPDLRPMVQLDGGRFAASDLNDLYRRVINRNNRLARLLELGAPGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLGKRVDFSGRSVIAVGPTLKMYQCGVPRLMAIELFKPFVMREIVAREYAGNVKAAKRMVERGDERIWDILEDVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNADFDGDQMAIHVPLSEEAQAEARLLLLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEDEGREGEGMIFKDIDEAVMAYHNGYVHLHSRVGIAVDSMPDKPWKENQLHKILVTTVGKILFNSIIPSEIPYLQETTNENLTDSTPDKYFLEPGQDIQTVIDSLEINAPFKKKHLGNIIAEIFKRLRTTETSAFLDRLKDLGYYYSTLAGLTVGIADIPVIDNKQEIIDAAHHRVEEINKAFRRGLMTEDDRYVAVTTTWREAKDALEKRLIETQDPKNPIVMMMDSGARGNISNFSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSGYLTRRLVDVAQDVIIREDDCGTDRGLVIRAITDGKEVTETLEERLFGRYTKKSVKHPETGEVIVGPDTLITEDMAAAIVNAGVEEVTIRSVFTCKTRHGVCRHCYGINLATGDAVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRIQEIFEARNPKGEAVITEVKGTVIEIEEDAATRTKKVFVQGKTGMGEYVVPFTARMKVEVGDEVHRGEALTEGSIQPKRLLEVRDTLSVETYLLAEVQKVYRSQGVEIGDKHVEVMVRQMLRKVRVMDPGDTDLLPGTLMDISDFTDANKDIVISGGVPATSRPVLLGITKASLETNSFLSAASFQETTRVLTDAAIRGKKDHLIGLKENVIIGKIIPAGTGMARYRNIEPLAVNEVEVIENIAVDEAIVESSED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RL2_BIFAA
Sequence: MAIRVYKPTTAGRRNASVSDFSELTRSTPEKSLVRKLSKTGGRNSYGRMTSRHRGGGHKRQYRLIDFKRWDKDGVPAKVAHIEYDPNRSARIALLHYADGEKRYIIAPEGIKQGDVIETGAQADIKPGNNLPLRNIPTGTVVHAIELRPLGGAKIARSAGAAVQLVAKDGAYAQLRMPSGEIRNVDARCRATVGEVGNSDHANIQLGKAGRARWMGKRPITRGESMNPVDHPHGGRTRGGKPPVSPWGKGEVRTRRPKKASNKMIVRRRPNGKNRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CLPS_AERHH
Sequence: MSKQKELFANEEIAEAEKTKLQPPPMYKVVLNNDDYTPMEFVVEVLQKFFGMDLDKATQVMLSVHYSGKGVCGTFTAEIAETKVVQVNTYARNNEHPLLCTMEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: PAND_MYCLE
Sequence: MLRTMLKSKIHRATVTQAYLHYVGSVTIDADLMGAADLLEGEQVTIVDINNGARLVTYAIAGERGTGVIGINGAAAHLVHPGDLVILISYGTMEDAEAHAYQPRIVFVDADNKPIDLGHDPGSVPLDISVAAELFDPRIGAR
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URED_BURTA
Sequence: MSAHDPHASLARPAAKAWHARLELGFERQPGGRTALAHRRHVGPLRVQRALYPEGDAICHAVIVHPPGGVAGGDRLEIDVKLDAGTHAVLTTPGATKWYKSNGLDARQRIDIDVGARAKLDWLPQNNLFFDATHASLEFVLKLGDGASVLGWDAAQLGRQAAGEAWSTGSVASFSKIVGPSGRALWVERARLDARDPLRAAPQGLGGFPVYGTLWALGPACTNALAESIAPALPFDDALRAGVTCIAPGTMLIRALAHSMEALQHLFAEQWLALRPIVHGIDAKPLRLWQT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_WOLSU
Sequence: MATVIRLTRLGRKKKPFYRMVVTDSRKRRDGGWVEAIGYYNPLAETPVVKFDAERLKYWVSVGAKMSDRVATLTASK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: CLD18_RAT
Sequence: MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVQQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGVIGILVSIFALKCIRIGSMDDSAKAKMTLTSGIMFIISGVCAIIGVSVFANMLVTNFWMSTANMYSGMGGMVQTVQTRYTFGAALFVGWIAGGLTLIGGVMMCIACRGLTPDDRNFKAVSYHASGQNVAYKPGGFKASTGFGSNARNKKIYDGGARTEDDEQSHPTKYDYV
What is the function of this protein?
Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification.
What are the official names of this protein?
Claudin-18.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
Protein: HUPE_RHILV
Sequence: MKYSKITTTLAALALPSIAHAHVGLHADGTLAGLNHPFSGLDHILAMVAVGFWASTLGGKAVWIVPSAFVIVMAGGGVLGIEGIALPMVETAIALTVAMLGLLVAFEVKIPTPVAAIVVGICALFHGHVHGIELPTMSNATGYVAGFLAATVILHVLGIGLASLRFGKAGQVVARVAGGAVALAGAALLVG
What is the function of this protein?
Needed for full hydrogenase activity.
What are the official names of this protein?
Protein HupE.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLPS_XANCP
Sequence: MPRKTSHEHDHGLVVETSKPEVAPPPRYQVLLLNDDYTPMDFVVTVLQQFFNLELERATQVMLHVHTRGRGVCGVYSREVAESKVAQVNEFSRMNQHPLLCTMEQA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: NTPPB_ECOL6
Sequence: MPKLILASTSPWRRALLEKLQISFECAAPEVDETPRSDESPRQLVLRLAQEKAQSLASCYPDHLIIGSDQVCVLDGEITGKPLTEENARLQLRKASGNIVTFYTGLALFNSANGHLQTEVEPFDVHFRHLSEAEIDNYVRKEHPLHCAGSFKSEGFGITLFERLEGRDPNTLVGLPLIALCQMLRREGKNPLMG
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADD_SOLUE
Sequence: MKLAIFGGTFDPIHAGHLAAAREASTRFALDRVLFIPAAHPPHKAGVTHAPYDDRVRMAELACRDDARFEVSRLEEGTARSYSIDTIEKVRAMLAPGDGLYFLIGADAFAEIRTWRRWTDVARAVRFLVVSRPGHTYEIPAEVTVDRIDSLEIPISSSEIRRTLAAGGIPEGLPPAVLAYARDHHLYN
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: Y1690_CLOTE
Sequence: MKVEELIERINYLYKKSKEEGLTEEEKIEQAELREKYLKNIRSNFRAQLESIGGVSKKQS
What are the official names of this protein?
UPF0291 protein CTC_01690.1.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THS5_VITVI
Sequence: MASVEEIRNAQRAKGPATILAIGTATPDHCVYQSDYADYYFKVTKSEHMTELKKKFNRICDKSMIKKRYIHLTEEMLEEHPNIGAYMAPSLNIRQEIITAEVPKLGKEAALKALKEWGQPKSKITHLVFCTTSGVEMPGADYKLANLLGLETSVRRVMLYHQGCYAGGTVLRTAKDLAENNAGARVLVVCSEITVVTFRGPSEDALDSLVGQALFGDGSAAVIVGSDPNVSIERPLFQLVSAAQTFIPNSAGAIAGNLREVGLTFHLWPNVPTLISENIEKCLSQAFDPLGISNWNSLFWIAHPGGPAILDAVEAKLNLEKKKLEATRHVLSEYGNMSSACVLFILDEMRKKSLKGEKATTGEGLDWGVLFGFGPGLTIETVVLHSVPMVTN
What is the function of this protein?
Mediates resistance to pathogens which are sensitive to stilbenes.
What are the official names of this protein?
Stilbene synthase 5, Resveratrol synthase 5, Trihydroxystilbene synthase 5, StSy 5.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE4_HPV57
Sequence: MEDSEVPRPPPRTTTHYPLLDLLRPQSQPQPQPQQQSRPHSRTPPRRHRVRHPSASGSSSDSSGNSPTLRGRSEKGRWSVKTTGASVTLTAQTPGGATVTLTLCL
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: Y105_ABVP
Sequence: MICKDGFLINEENGEVIDYCYENNEMVQDKELEHYSVTPPVPYVPEKYKEKMKEYNKWLKGKEAFIQLKMKAVKKIEYLKNLCANEETQINKRTRKSRRLLTPKT
What are the official names of this protein?
Uncharacterized protein ORF105.
Protein: ABCG_ASPFU
Sequence: MDTPSSGTIDLEHGEAGLRKRLTLTFRSVSVHVTAPDAALGDTLLSVADPRQFLGFLKGSRPKRTILKDVSGQVKPGEMLLVLGRPGSGCTSLLRVLSNDRESFDEVIGETRYGSMDHVAARRFRQQIMFNNEDDVHFPTLTVNRTMKFALRNKVPRERPDGQGSKEFVQEQRDNILSALGIRHTTKTLVGNEFIRGVSGGERKRVSLAEVIAGQSPIQVWDNPTRGLDSKTAVEFARLLRREADMNQKTMVATMYQAGNGIYNEFDQVLVLADGRVTYYGPRQLAKSYFEDMGFVCPKGANVADFLTSVTVLTERIVRPGMEDKVPSTAEEFEARYRQSDIHQKAMEGFDPPEKLTHEVDELTAAVASEKRKRHLPRSPSVYTTSLWEQIQACTIRQFQIMAGDRLSLIIKVVSAILQALVCGSLFYNLKDDSSSIFLRPGALFFPVLYFLLESMSETTASFMGRPILSRQKRFGFYRPTAFCIANAITDIPVVLVQVSCFCIILYFMAALQMDAGRFFTYWIIVIANTLCFMQMFRAVGALCKRFGNASKITGLLSTIFFVYGGYLIPYEKMHVWFRWIFYLNPGAYAFEALMANEFVGKSLQCVQPDYIPYGSGYPGSESPYRGCSIPGSEGDVILGAAYIRAQYNYSWHHIWRSFGVIIGFWVFFIVLTALGLELLNSQGGSSVLLYKRGSQKTRSEDTTTPVQEAARASHAKQSTFTWHDLDYHVPYQGQKKQLLDKVFGFVKPGNLVALMGCSGAGKTTLLDVLAQRKDSGEIYGSILIDGRPQGISFQRTTGYCEQMDVHEPTATVREALVFSALLRQPAHVPREEKLAYVDHIIDLLELRDISDALIGVPGAGLSIEQRKRVTLGVELVAKPTLLFLDEPTSGLDGQSAYNIIRFLRKLVDGGQAVLCTIHQPSAVLFEAFDSLLLLARGGKMAYFGETGKDSQTVLDYFARHGAPCPPDENPAEHIVEVIQGNTDKPIDWVQVWNESEEKQRALAQLQTLNARGKADADYVEDTADYATSKWFQFTMVTKRLMVQLWRSPDYVWNKVILHVFAALFSGFTFWKIGDGAFDLQLRLFAIFNFIFVAPGCINQMQPFFLHNRDIFEAREKKSKIYHWLAFIGAQTVSEIPYLILCATLYFACWYFTAGFPTTASISGHMYLQMIFYEFLYTSIGQGIAAYAPNEYFAAVMNPVLIGAGLVSFCGVVVPFSQMQPFWRDWLYYLDPFTYLVGGLLGEVLWDVEVRCDPSELVRFRAPLGQTCGEYMAAFLAEKPGYLVDGNATACEFCQYSTGADYARTFNLKERYYSWRDTGITALFCVSSYAMVFLMMKLRSKKTKSARSE
What is the function of this protein?
ABC efflux transporter that seems not to be able to transport azoles, nor rhodamine 6G (R-6G), a known substrate for many ABC transporters.
What are the official names of this protein?
ABC multidrug transporter G.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GPDA_VIBVY
Sequence: MTQTLVNNAYGKEISMTVIGAGSYGTSLAISLSRNGANVVLWGHEPEHMAKLEADRANHEFLPGIEFPPSLIVESDLAKAVQASRDLLVVVPSHVFGIVLNSLKPYLRDDSRICWATKGLEPETGRLLKDVAFDVLGEHYSLAVLSGPTFAKELAAGMPTAISVASPDAQFVADLQEKIHCSKTFRVYANSDFTGMQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMCRLGAALGAQPETFMGMAGLGDLVLTCTDNQSRNRRFGLALGQGKDVDTAQADIGQVVEGYRNTKEVWMLAQRMGVEMPIVDQIYQVLYQGKDARLAAQDLLARDKKSEGK
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIM16_KLULA
Sequence: MAHRAFIQVIFTGAQVFGRAFAESYRQAAAQTAKQTANASRGRGASAEYGGITLDESSKILNIENEQDMNLDKINERFKYLFEINDKEKGGSFYLQSKIYRAAERLKYELAEKEKAANPELNQEQAKSSSTTESPELKK
What is the function of this protein?
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14.  May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM16, Presequence translocated-associated motor subunit PAM16.
What is the protein family that this protein belongs to?
Belongs to the TIM16/PAM16 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein.
Protein: CP6G2_DROME
Sequence: MELVLLILVASLIGIAFLALQQHYSYWRRMGVREIRPKWIVGNLMGLLNMRMSPAEFISQLYNHPDAENEPFVGIHVFHKPALLLRDPEMVRNILVKDFAGFSNRYSSSDPKGDPLGSQNIFFLKNPAWKEVRLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCFDLEAKELCALYTTDVIATVAYGVSANSFTDPKCEFRRHGRSVFEFNLLRAAEFTLVFFLPHLVPFVRFKVVPAEATRFLRKTINYVMSEREKSGQKRNDLIDILIEFRRSTQLAKASGIKDQFVFEGDILVAQAVLFFTAGFESSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEFMQMILLEVLRMYPPLPFLDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPENRKLHTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPHRMQLDPKAIITQAKGGIHLRLVRDALGV
What is the function of this protein?
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Probable cytochrome P450 6g2, CYPVIG2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: RL20_STRA3
Sequence: MARVKGGVVSRKRRKRVLKLAKGYYGAKHILFRTAKEQVMNSYYYAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVNDAAAFTALADAAKAKLGK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.