PharMolix/UniProtQA huggingface dataset:
Protein: IL10_MACMU
Sequence: MHSSALLCCLVLLTGVRASPGQGTQSENSCTRFPGNLPHMLRDLRDAFSRVKTFFQMKDQLDNILLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENHDPDIKEHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFSKLQEKGVYKAMSEFDIFINYIEAYMTMKIQN
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: IHFA_BRASO
Sequence: MAGTGKTVTRVDLCEAVYQKVGLSRTESSAFVELVLKEITDCLERGETVKLSSFGSFMVRKKGQRIGRNPKTGTEVPISPRRVMVFKPSAILKQRINGQQANGKMNGESAPSEFSAETE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: MECA_STRT2
Sequence: MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDLKEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAFSDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDALPVLQATKWS
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: BICD1_MOUSE
Sequence: MAAEEALKTVDQYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDGLKQELEQLREAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLNKILEMQNELKQSRAVVTNVQAENERLSAVVQELKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYINLSDSHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLGKLNGDYRTPTTRKGESLHPVSDLFSELNISEIQKLKQQLIQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQNSKEIKAELDCEKGRNSAEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTEEKTKYESKIQMYDEQVTNLEKTSKESGEKMAHMEKELQKMTGIANENHNTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLSRRGVSSPVESRTSSEPVSKENTETSKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLLPPYRHSAHN
What is the function of this protein?
Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
What are the official names of this protein?
Protein bicaudal D homolog 1, Bic-D 1.
What is the protein family that this protein belongs to?
Belongs to the BicD family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: RS3_XANP2
Sequence: MGQKVNPVGLRLGINRTWDSRWFANKGEYGKLLHEDIKIREMLFKQLKQAAVSKVVIERPHKKCRVTIYSGRPGVVIGKKGADIDKLRKKVSEMTSSEVFINIVEIRKPEIDARLVAESIAQQLERRVAFRRAMKRAVQSAMRLGAEGIRINCSGRLGGAEIARLEWYREGRVPLHTLRADVDYGTATAFTTYGTCGVKVWVFKGEILEHDPMAQDKRQAEQEAGPSSRPQRRERGDRERGDRGDRDRGHRA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: GL19_ORYSJ
Sequence: MASKVVFFAAALMAAMVAISGAQLSESEMRFRDRQCQREVQDSPLDACRQVLDRQLTGRERFQPMFRRPGALGLRMQCCQQLQDVSRECRCAAIRRMVRSYEESMPMPLEQGWSSSSSEYYGGEGSSSEQGYYGEGSSEEGYYGEQQQQPGMTRVRLTRARQYAAQLPSMCRVEPQQCSIFAAGQY
What is the function of this protein?
Seed storage protein.
What are the official names of this protein?
19 kDa globulin, Alpha-globulin.
What is the protein family that this protein belongs to?
Belongs to the 2S seed storage albumins family.
What are the subcellular locations of this protein?
Secreted.
Protein: DDL_LACDA
Sequence: MTKKTQVGLIFGGNSSEYEVSITSAGNIYKAIDKDKFDVHPIWITNSGYVASEADSYKVLEEPGYMVEKNDKTANLSNLIELASRPELDVLFPIVHGNLGEDGVLQGLFRLIDKPFVGVDVLAAAVTMDKEFTKILAQRAGVPVAKWVSIKRYEYEDAKNQKLSYDWVSGQLGTSNLFVKPSNQGSSVGITHVTDDSNYAEALAEAFKYDDKVLVEEGIVGTEVETAVLGNDHPVVSGVGQIINADNTWYSYENKYSTESTTTLQIPAQIPAETAEKVQENALKIYQITECSGMARVDSMLRESDGEVIFNELNALPGFTNISMYPKLFEEAGISYPDLITRLIRLAEERYAHKKTLLRKHD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_SERP5
Sequence: MRLCDRDIEAWLDCEKLVISPRPPIERINGATVDVRLGNQFRVFRGHTAAFIDLSGPKDEVSAALDRVMSDEIVLPEGEAFFLHPGELALAVTLESVTLPNDLVGWLDGRSSLARLGLMVHVTAHRIDPGWQGRIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAARPYNSRQDAKYRDQQGAVASRIDKD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: FAEC_EMENI
Sequence: MLRAVLLPTLLAFGAFTPVHGANSPGCGKQPTLTNGVNQINGREYVLKIPDGYDPSKPHHLIFGLHWRGGNMYNVVNGDSIQPWYGLEARAQGSAIFVAPNGLNAGWANTNGEDVAFIDAIMEQVEDDLCVDQASRFATGFSWGGGMSYALACARAAEFRAVSVLSGGLISGCDGGNDPIAYLGIHGINDPVLPLDGGVTLANTFVSNNGCQPTDIGQPASGSGGSVRTDFSGCSHPVSFIAYDGGHDGAPLGVGSSLAPDATWEFFMAA
What is the function of this protein?
Involved in degradation of plant cell walls.  Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin.  Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.
What are the official names of this protein?
Feruloyl esterase C, Ferulic acid esterase C, FAEC.
What is the protein family that this protein belongs to?
Belongs to the faeC family.
What are the subcellular locations of this protein?
Secreted.
Protein: KTR7_YEAST
Sequence: MAIRLNPKVRRFLLDKCRQKRYGFLFLGCIFAILYCMGTWPFFAKDIVHDPNNLPYSLQDYSTDKDEPFFRGCTDTKLYLQNPAYSKMNASFVMLTRNEEIEDVLKTMRSIEGHFNKWFKYPYVFLNDDPFTDHFKDQIQAATNATVEFGTVDEIMWEFPAKVRNSLQFKASLEDQNDRGIMYGNMESYHKMCRFYSGIFYKHPLVSKYEWYWRIEPDVDFFCDISYDPFFEMAKHNKKYGFTVLITELYWTVPNLFRTTKSFIKKTAGLKENLGTLWKLFTFNYNILDTDDEEISRWVNFPWDAKPKLTEKLMVDFLLENHGQVNNEEDLEGIQYLVERARSKVPMLEDSLEGEDYNLCHFWSNFEIARVDLFDNEIYNAYFKFLEESGGFWTERWGDAPIHSIGLGMTLDLEDVHYFRDIGYRHSSLQHCPKNALQSQENLNTFDEGYNFGCGCRCVCPKKGEDIEDHSTPCMDIFFELLHGREYEKEFPGCYKPSIKDKDVIEEIRRENFRVIE
What is the function of this protein?
Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
What are the official names of this protein?
Probable mannosyltransferase KTR7.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 15 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: CARB_STAAR
Sequence: MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEIADKVYIEPLTHNFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTELTSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGGICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRFPFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYIKERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLEYLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTYETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVSTDFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLENLNRAEDRKEFEALLRKINVPQPQGKTATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIVDNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHSGDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRTVPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITLGPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQCLNEVGYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGFQIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: HIS8_ERYLH
Sequence: MSDTRPQIKTWIEGIHAYVPGKATGAQGQALIKLSANENPLGCSPKALEALDAPGNPATYPDPDAKALRAKLAEVHGLDAGRIVCGTGSDELLNLAAQAFAGPGDEVLFSTYSFSVYDIAARRCGATPVEAPDADYAADVDALLAAVTDKTRVVFVANPNNPTGSFLPRDEIARLHAGLPQDVLFVLDQAYAEYLTPEEDDGGFALAAAHENVLVTRTFSKAYGLAGERIGWATGAPHFIDALNRVRGPFNVTNSGQAAALAGVDDQNFIDRTRDHNTRELTRFTDAMAALGNHGIRPLPSKANFALVLFEGTLAAETALSALADAGYAVRHLPGQGLPHGLRITIGTAEDMDRIARTIAEAAEAAQ
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: TMED1_RAT
Sequence: MMAAGAAVALALWLLLPAVGVGEAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYRLCFDNSFSTISEKLVFFELIFDSFQDEEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEDNLERVNFWSAANVAVLLLVAVLQVCTLKRFFHDKCPVPT
What is the function of this protein?
Potential role in vesicular protein trafficking, mainly in the early secretory pathway.  May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.  Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1.  Plays also a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.
What are the official names of this protein?
Transmembrane emp24 domain-containing protein 1, Interleukin-1 receptor-like 1 ligand, p24 family protein gamma-1, p24gamma1.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein.
Protein: MGSA_CLOBA
Sequence: MRIALIAHDKKKQDIIEFAKRNKETLEKYELLATGTTGKMISEETGLNIKRYLSGPYGGDQQIGGRIAEGTIGLVIFFRDPLTAQPHEPDVSALLRVCDVHNIPVVTNSGTADLIIRQF
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: GCSPA_GEOSM
Sequence: MGYCPNTPDEIREMLAVIGAGSIEELFAPIPAELRAKSFDLPPGMSEFELMRIMREKAAAGGAEILPFIGGGIYDHIIPAAVDHLSSRAEFYTAYTPYQPECSQGTLQALFEYQTSICRLTGMEASNASLYDGGTAVAEAALMSLRITERNRVILDASVNPLHREIVTGYLHGLSAEAVEVAPDGCGSNLKALSGSIDEETAAVIVQNPNFFGSVQDFSELALKAHEKGALLIVSGYPIALGLVASPGEMGADIAVGDGQSLGNPLSFGGPYFGFIAARKRFIRNLPGRIVGETIDNQGRRGYVLTLQAREQHIKRHKATSNICSNQSLCALRGLIFCASLGKKGFEELALLNYDKAQYAKSRLSSLKGVTLMNAGTTFNEFTLSLPKDAAPVVEKLLSFGVAAGVPLGQYYPGMDSALAVTVTEKRSKAEIDRLAALLEEALCS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: HIS3_SYNAS
Sequence: MLEPDFVKGNGLIPAIVQDCITGEVLMLAYMNRESWLKTRESGKATYWSRSRNSLWIKGETSGHYQIIKEILIDCDADAIVLKVQQTGAACHTGYRSCFYRKIVGESFEIIGEKLVDPEEVYK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPK13_ARATH
Sequence: MEKREDGGILTYDGRYVMYNVLGNIFELSSKYIPPIEPIGRGAYGIVCCATNSETNEEVAIKKIANAFDNRVDAKRTLREIKLLSHMDHDNVIKIKDIIELPEKERFEDVYIVYELMDTDLHQIIRSTQTLTDDHCQYFLYQILRGLKYIHSANVLHRDLKPSNLVLNTNCDLKICDFGLARTSNETEIMTEYVVTRWYRAPELLLNSSEYTGAIDIWSVGCIFMEILRRETLFPGKDYVQQLKLITELLGSPDDSDLDFLRSDNARKYVKQLPHVQKQSFREKFPNISPMALDLAEKMLVFDPSKRITVDEALKQPYLASLHEINEEPTCPTPFSFDFEETALDEQDIKELVWRESLHFKNM
What is the function of this protein?
MKK6-MPK13 module positively regulates lateral root formation.
What are the official names of this protein?
Mitogen-activated protein kinase 13, AtMPK13, MAP kinase 13.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: Y709_XYLFT
Sequence: MVEQLLLPLWNNLATVDDETLPLMSTALLIARDEYPDLDANLYDTLVQSYVEYLRSEVEEISLWPLKMAAVNRYLFQKLGYSGNHDEYYDPRNSYLNQVFERRLGNPISLAVIQIEVARRLGIPLDGVSFPGHFLVRLPVDDGILVMDPFNGGRPLDAEELRERARPHLGGEAPDDRALAQILNPAPHRTILVRILRNLHSVYANTDRWDRAARCADRILKLVPNQPEALRDRGLAYLQLGHRSGALNDLKRYLQLYPSTHNVDMVRGHLVDLSNERIQTH
What are the official names of this protein?
UPF0162 protein PD_0709.
What is the protein family that this protein belongs to?
Belongs to the UPF0162 family.
Protein: RPOZ_LISIN
Sequence: MLYPSIDNLLLKIDSKYSLVTVAAKRARYMQLENDKGVLPSYQSDKFVGKALEEIHAGKLVLQNDEK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PSBP_PINST
Sequence: GEAANVMGAPK
What is the function of this protein?
May be involved in the regulation of photosystem II.
What are the official names of this protein?
Putative oxygen-evolving enhancer protein 2, OEE2, 23 kDa subunit of oxygen evolving system of photosystem II, 23 kDa thylakoid membrane protein, OEC 23 kDa subunit, PS11.
What is the protein family that this protein belongs to?
Belongs to the psbP family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Protein: FIB_STAAW
Sequence: MKNKLIAKSLLTIAAIGITTTTIASTADASEGYGPREKKPVSINHNIVEYNDGTFKYQSRPKFNSTPKYIKFKHDYNILEFNDGTFEYGARPQFNKPAAKTDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVK
What is the function of this protein?
Extracellular fibrinogen-binding protein that plays an important role in virulence.  By interacting with the alpha chain of fibrinogen and its derivative fibrin, enhances a non-functional interaction between fibrinogen and platelets and is responsible for repression of fibrinogen-dependent platelet aggregation.  In addition, assembles a fibrinogen protective shield around the bacteria which results in impaired phagocytic clearance by the host.  Mechanistically, interacts with host complement C3b deposited on the surface of the bacterium via its C-terminal and then recruits fibrinogen via its N-terminal.
What are the official names of this protein?
Fibrinogen-binding protein.
What are the subcellular locations of this protein?
Secreted.
Protein: BMP2_TETNG
Sequence: MVAVVRSLMVLLLAQVLLEGATGLIPEVGRRRYSESGKQSPQQSEGFLNEFELRLLNMFGLKRRPTPSKQAVVPQYMVDLYRMHSANGDHSAKRPKSMGRHAERAASKANTIRSFHHEESMEALARLKGKTTQQFYFNLTSIPKEELITSAELRIYRDQVMGAASTNNSSTNSSTSDKAHAGGFHRINIYEIFGVPQGREPLARLLDTRLVQDSLTRWESFDVSSAVFQWTSGKGHNHGFMIEVLHPEEGEVEQERADKHSRHVRVSRSLHQDRDSWPQARPLLVTYGHDGRGDSVLHTREKRQAALRKQRRKHQHKASCKRHALYVDFSDVGWNEWIVAPPGYHAFYCQGECPFPLADHLNSTNHAIVQTLVNSVNSNIPRACCVPTDLSPISLLYLDEYEKVILKNYQDMVVEGCGCR
What is the function of this protein?
Induces cartilage and bone formation.
What are the official names of this protein?
Bone morphogenetic protein 2, BMP-2.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: EFG_IDILO
Sequence: MARKTSIERYRNIGICAHVDAGKTTTTERVLFYTGLSHKIGEVHDGAATMDWMEQEQERGITITSAATTCFWQGMDKQFPEHRVNIIDTPGHVDFTIEVERSLRVLDGAVVVLCASSGVQPQTETVWRQANKYEVPRMVFVNKMDRAGADFLSVVHQMKTRLAAQAVPMQLPVGAEDNFRGVVDLVKMKFINWSEEDMGTSFTYEDIPADMVDECEKYHGELVEAAAEANEELMNKYLEEGELTEAEIKQGLRIRTLANDICLVACGSAFKNKGVQAVLDAVIEYLPSPTEVKPITGILDDESEGVRKSSDEEPFSALAFKIATDPFVGTLTFVRVYSGVLNQGDGVVNPVKNKKERVGRMVQMHSNSREEIKEVRAGDIAALIGLKDVTTGDTLCDPAHKITLERMEFPEPVISVAVEPKTKADQEKMGIALGKLAAEDPSFRVKTDEESGQTIISGMGELHLDIIVDRMKREFKVECNVGQPQVAYREAIRDAVEIEGKFVRQSGGRGQFGHVWLKLEPMTIEEDANGDDITYKFVNEIVGGVVPKEYIPAVDKGIQEQMQQGVLAGYPVLGVKATLYDGSYHDVDSSEMAFKIAGSMAFKKGALKANPALLEPMMKVEVITPEESMGDVVGDLNRRRGLIEGMEEAPGGLKAVNAQVPLSEMFGYATDLRSQTQGRASYSMEFLKYAEAPNNIAEKVMAERNAK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_CLOAB
Sequence: MNIDSHTFLLGMQYLGAGLAAIGCIGGGVGIGTVTGKAVEAIGRQPESASKVMPTMIMGLAFAEVTSLYALFVAIMLLFVK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RBFA_PSECP
Sequence: MADPARAAKLAQRIKVVVAEALGRKVKDPRLEGVTVTDARVTNDLQHATVYYTVFGDETAHADAAKGLEKAKGVLRQEVGRNITVRLTPTLEFVADQIPVVASNLEELLREARKRDAEVAALAATAKHAGEADPYKSDAPEDVDIDEDDFDEEDIDLAGDDDIDEDANKDADSSK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_RHIWR
Sequence: MARVKRGTTTHAKHKRILGAAKGYYGRRKNTIRIARQAVEKAGQYAYRDRKVKKRSFRALWIQRINAAVRAEGLTYGVFMHGLKLAGIELDRKVLADIAMHEGEAFSGIIAQAKAALPEGARIAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: EFP_CLOP1
Sequence: MISGSDLRKGTTFELDGQVYTVIDFLHVKPGKGAAFVRTKLRNVIMGGVTDRTFNPTDKLQEAIIERKEMQYLYSDGELYYFMDQETFEQIPLNHEKVEDAIKFLKENMNAVIKFYKGEAFSVEAPNFVELLITECEPSVKGNTATTAMKTAVVETGATVMVPMFVEEGNTIRIDTRTGEYMERV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCS22_LEGPL
Sequence: MRLLSFKKSKIVSIGTELEFQIIDCSSLSLVSRSKELMRALKDMRYRDQIKPEITQSMIEINSSIHQSAKEMYDELLELQKILVETAASIDIAFCGGGTHPFQQWTMQKIFPSKRFKKKFNQYRYLSKRATVFGQHIHIGCPTGDDAIYLTHALARYVPHFIAISASSPFYLGINTNYCSSRSTIFNAFPLSGVIPYLRNWQEFSDYYRKMYRWKIIENMKDFYWDIRPKPELGTIEIRVCDTPLTLRKSILITAYIQALALYLLEEKPVELSHDLYYVYNYNRFQASRHGLEGELTVTDKDRPIPIMDDILETIKKIEQYINELGNNEYIEELYSDVINKQNDSVLINKMYKQDGSFSKLVAAQCELWLSDSKDRKWMTQPS
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2-2, Gamma-glutamylcysteine synthetase 2-2, GCS 2-2, Gamma-GCS 2-2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: RBFA_SYNC1
Sequence: MDHPRPHRVGEQLQKEISALLLKGLKDPRVGFVTITAVSVTPDMHLARVYYTVYGEEEQRKETQKGLESATPFFRRELGRRLRMRYVPDLVFEFDKALEYGNRIESLLRQLNEDKPSDD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.