Protein: OLCL_PENCN
Sequence: MANIGGSNAVSSAQGSQISDSPTTVDDRLDEHKETSTQSIDHSENITQSPTSLQKPPDESNATPVGFGEDGCQSDSQEYPNSWRLAAIMIGVCLAVFSMALDNTILATAIPKITDQFTSLGDVGWYGSVYPLTNCCLTLVFGKLYTFYSTKWVYLSALAVFEIGSLICGATPSSLGLIIGRAIAGLGSSGIYLGSMIILSQSVPLQKRPLFTSLVGGLYGVAGVAGPLLGGAFTDYVSWRWCFYINPLFGAVTALFILLFFDGKEPIKSPGKIKEQISQFDLIGLFFFLPGMISLLLALQWGGQQYNWQSGRIIGLFVCSICLLSIFIMVQWRQKEKATVTLRMIKNKNVWGASLFNFCITGSFLVFSYYLPVWFQSIKNVSATKSGLMNLPMLLGVILCSIISGYGVGRIGYYTPFMYAAPIVSAIGAGLLSTFQANFGPSQWIGYQALYGIGLGLGLSQPIVVIQAAIPLIDIPSAIAIVTFIQSLGGSVSVSIAQNVFRNELLRGLAQNAPKVDAHKLITAGPTTLRYVVPAELLERVLVAYNSAITHAFYVGAAFSVLAMIGALPIQWISVKGRE
What is the function of this protein?
MFS-type transporter; part of the gene cluster that mediates the biosynthesis of 15-deoxyoxalicine B (PubMed:30090271).  The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase olcI (PubMed:30090271).  Nicotinyl-CoA is then a substrate of polyketide synthase olcA to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase olcH to yield geranylgeranyl-HPPO (PubMed:30090271).  Geranylgeranyl pyrophosphate is provided by the cluster-specific geranylgeranyl pyrophosphate synthase olcC (PubMed:30090271).  The FAD-dependent monooxygenase olcE catalyzes the epoxidation of geranylgeranyl-HPPO and the terpene cyclase olcD catalyzes the cyclization of the terpenoid component, resulting in the formation of the tricyclic terpene moiety seen in predecaturin E (PubMed:30090271).  The cytochrome P450 monooxygenase then catalyzes the allylic oxidation of predecaturin E, which is followed by spirocylization with concomitant loss of one molecule of water to form decaturin E (PubMed:30090271).  Decaturin E is the substrate of the cytochrome P450 monooxygenase olcJ which hydroxylates it at the C-29 position to form decaturin F (PubMed:30090271).  The short-chain dehydrogenase/reductase olcF may catalyze the oxidation of decaturin F to generate the 29-hydroxyl-27-one intermediate, and subsequent hemiacetal formation probably leads to the formation of decaturin C (Probable).  The dioxygenase olcK may be a peroxisomal enzyme that catalyzes the hydroxylation of decaturin C into decaturin A once decaturin C is shuttled into the peroxisome by the MFS transporter olcL (Probable).  Finally the cytochrome P450 monooxygenase olcB catalyzes the oxidative rearrangement to yield 15-deoxyoxalicine B (PubMed:30090271).  In the absence of olcJ, decaturin E may be shunted to a pathway in which it is oxidized to a ketone, possibly by olcF, to form decaturin D, which undergoes further allylic oxidation to yield decaturin G (PubMed:30090271).  Moreover, in the absence of oclK or oclL, oclB can convert decaturin C into 15-deoxyoxalicine A (PubMed:30090271).
What are the official names of this protein?
MFS-type transporter olcL, 15-deoxyoxalicine B biosynthesis cluster protein L.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein. Note=OlcL may be inserted in the peroxisomal membrane viathe import receptor pex19.