PharMolix/UniProtQA huggingface dataset:
Protein: ACOHC_HUMAN
Sequence: MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
What is the function of this protein?
Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
What are the official names of this protein?
Cytoplasmic aconitate hydratase, Aconitase, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: RL3_PROM0
Sequence: MSIGILGKKLGMSQLFDEKGNSVPVTLIEAGPCRITQLKTTALDGYTAVQIGYGLSKDKHISKPEKGHLLKSGEELLKHLKEYRVEETSSYEIGNQITVKNFEVGQKVDISGKSMGRGFAGYQKRHGFSRGPMSHGSKNHRAPGSTGAGTTPGRIYPGKRMAGRYGGKQITTKGLLVLKIDDQKNLLVVKGSVPGKPGSIINIKPNNIVGKKGGEKS
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: FBP1_STRPU
Sequence: MRTWLLAVLLLSVIAVTYGQGECDSDPCENGSTCQEGEGSYICQCPMGYDGQNCDRFTGSNCGYNVFDANGMIDSPNYPAMYNNRADCLYLVRITKARSITFTIEDFMTEVFKDVVEYGIGPEADFNQALGSFEGNLTQDDVIPAPFTVQGDQAWFIFSTDRNIVNRGFRITFSSDGDDCDPNLCQNGAACTDLVNDYACTCPPGFTGRNCEIDIDECASDPCQNGGACVDGVNGYVCNCVPGFDGDECENNINECASSPCLNGGICVDGVNMFECTCLAGFTGVRCEVNIDECASAPCQNGGICIDGINGYTCSCPLGFSGDNCENNDDECSSIPCLNGGTCVDLVNAYMCVCAPGWTGPTCADNIDECASAPCQNGGVCIDGVNGYMCDCQPGYTGTHCETDIDECARPPCQNGGDCVDGVNGYVCICAPGFDGLNCENNIDECASRPCQNGAVCVDGVNGFVCTCSAGYTGVLCETDINECASMPCLNGGVCTDLVNGYICTCAAGFEGTNCETDTDECASFPCQNGATCTDQVNGYVCTCVPGYTGVLCETDINECASFPCLNGGTCNDQVNGYVCVCAQDTSVSTCETDRDECASAPCLNGGACMDVVNGFVCTCLPGWEGTNCEINTDECASSPCMNGGLCVDQVNSYVCFCLPGFTGIHCGTEIDECASSPCLNGGQCIDRVDSYECVCAAGYTAVRCQINIDECASAPCQNGGVCVDGVNGYVCNCAPGYTGDNCETEIDECASMPCLNGGACIEMVNGYTCQCVAGYTGVICETDIDECASAPCQNGGVCTDTINGYICACVPGFTGSNCETNIDECASDPCLNGGICVDGVNGFVCQCPPNYSGTYCEISLDACRSMPCQNGATCVNVGADYVCECVPGYAGQNCEIDINECASLPCQNGGLCIDGIAGYTCQCRLGYIGVNCEEVGFCDLEGMWYNECNDQVTITKTSTGMMLGDYMTYNERALGYAAPTVVVGYASNNYDFPSFGFTVVRDNGQSTTSWTGQCHLCDGEEVLYTTWINTNMVSTCQDIKKSNMVGQDKWTRYEQSIAPQPDA
What is the function of this protein?
Forms the apical lamina, a component of the extracellular matrix.
What are the official names of this protein?
Fibropellin-1, Epidermal growth factor-related protein 1, Fibropellin-I, SpEGF I, UEGF-1.
What are the subcellular locations of this protein?
Secreted, extracellular space. Cytoplasmic vesicle. Secreted, extracellular space, extracellular matrix, hyaline layer. Secreted, extracellular space, extracellular matrix, apical lamina. Note=In vesicles in the cytoplasm of unfertilized eggs, then to the base of the hyaline layer throughout development and finally in the apical lamina in late embryos and early larvae.
Protein: RL6_HALHL
Sequence: MSRVAKAPVEVPSGVEVTLQGNDIQVKGPKGQMAWSCHRLVSLNQEEGTLTFEPRQQSTRAVALTGTTRALVQNMVTGVSEGFERRLELKGVGYRAQVQGSTLNLTLGFSHPVHYEIPEGVTIECPSQTEVVVKGADKQQVGQVAAQIRGYRPPEPYKGKGVRYADERVVLKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: PVK1_BANRO
Sequence: GSTGLISFGRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, BanRo-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRTB_STRGR
Sequence: MRIKRTSNRSNAARRVRTTAVLAGLAAVAALAVPTANAETPRTFSANQLTAASDAVLGADIAGTAWNIDPQSKRLVVTVDSTVSKAEINQIKKSAGANADALRIERTPGKFTKLISGGDAIYSSTGRCSLGFNVRSGSTYYFLTAGHCTDGATTWWANSARTTVLGTTSGSSFPNNDYGIVRYTNTTIPKDGTVGGQDITSAANATVGMAVTRRGSTTGTHSGSVTALNATVNYGGGDVVYGMIRTNVCAEPGDSGGPLYSGTRAIGLTSGGSGNCSSGGTTFFQPVTEALSAYGVSVY
What is the function of this protein?
Has a primary specificity for large aliphatic or aromatic amino acids.
What are the official names of this protein?
Streptogrisin-B, Pronase enzyme B, SGPB, Serine protease B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: PEN2_BOVIN
Sequence: MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFIVPAYTEQSQIKGYVWRSAVGFFLWVIVLSTWITIFQIYRPRWGALGDYLSFTIPLGTP
What is the function of this protein?
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).  The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.  PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
What are the official names of this protein?
Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2.
What is the protein family that this protein belongs to?
Belongs to the PEN-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Protein: CHSY_PUEML
Sequence: MVSVAEIRQAQRAEGPATILAIGTANPPNCVDQSTYPDYYFRITNSEHMTELKEKFQRMCDKSMIKKRYMYLTEEILKENPNMCAYMAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKQLGLRPYVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIVGSDPIPQVEKPLYELVWTAQTIAPDSEGAIDGHLREVGLTFHLLKDVPGIVSKNIDKALFEAFNPLNISDYNSIFWIAHPGGPAILDQVEQKLGLKPEKMKATRDVLSDYGNMSSACVLFILDEMRRKSAENGLKTTGEGLEWGVLFGFGPGLTIETVVLRSVAI
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase, Naringenin-chalcone synthase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: WHIA_CLONN
Sequence: MSFSSKVKNEICRYTELSREEAIAELSGIMKVSGTLGFSGDMKMNFRVSTENPAIARLTFKLLKDHFNIHTKIFVKKSNSLKKNNIYLVVIDNNMGVKDLLKEVGVLKEEEGMITLDYSVPERMVRDDNCRRVFIRGVFLGGGSISNPEKTYHLEFVTHHEDYAKELSEVINTYGLNSKVIQRKSSFVIYLKEGEQIVDLLNIIGAHDSLLELENVRIMKEMRNNVNRLVNCETANLSKTVNAAVRQIGSIKLIEEEIGLQRLPENLREVAELRLNFPNESLKELGQMLDPPVGKSGINHRLRRIEKIAEELRKEGK
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: RS9_CHLCH
Sequence: MKEVIDTVGRRKTSVARAFLTPGKGTVTVNKRPVEEYFKDEFKRQQALRPLTLCEKAEEFDVKINVQGGGLSGQSGAVSLAIARALTESDEALRAVLRTERLLTRDPRMVERKKFGRKKARKRFQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RSMJ_ECO7I
Sequence: MKICLIDETGTGDGALSVLAARWGLEHDEDNLMALVLTPEHLELRKRDEPKLGGIFVDFVGGAMAHRRKFGGGRGEAVAKAVGIKGDYLPDVVDATAGLGRDAFVLASVGCRVRMLERNPVVAALLDDGLARGYADAEIGGWLQERLQLIHASSLTALTDITPRPQVVYLDPMFPHKQKSALVKKEMRVFQSLVGPDLDADGLLEPARLLATKRVVVKRPDYAPPLANVATPNAVVTKGHRFDIYAGTPV
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMB_CLOBJ
Sequence: MNIDIVISADHIDEKRLINKTVIIIDILRATSVITTAINNGCKKVIPVLTVEEAKDIAKNSKEDIILGGERNALKIDGFNFSNSPLEYTKKYVEGKTVVLSTTNGTRAINNSFNAKTILISALINSKATAKAIDKLNEDLIIINSGTNGQFSIDDFICSGYLIDCLYNIRKDLELSDIAKTAHYIYTNNKDIESFVKKATHYSRLKSLNLEKDLEYCFQKDIIDVVPQYKDGYIIKSNI
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.
Protein: SYE2_RICRO
Sequence: MNNNVITRFAPSPTGFLHIGSARTALFNYLFARHHNGKFLLRIEDTDKERSTKEAVEAIFSGLKWLGLDWNGEVIFQSKRNNLYKEAALKLLQNGKAYYCFTRQEEIERQRQQALENKQHFIFNSEWRDKDPSIYPTDIKPVIRLKTPREGSITIHDTLQGEVVIENSHIDDMVLLRADGTATYMLAVVVDDHDMGITHIIRGNDHLTNAARQLAIYQAFGYAVPSMTHIPLIHGADGAKLSKRHGALGIEAYKDMGYLPESLCNYLLRLGWSHGDDEIISMTQAIDWFNLDSLGKSPAKLDFAKMNSLNSHYLRMLDNDSLTSKIVEILEQNYNKLLQKLAYREEFGGNTERSTAAYIDIREDASTGLTYKLPLAVELPKKFKVSEQEIGYIKQAMPSLLVRSETLLELTRLAQIYLVDSPIIYSQDSKEIIENCDKNLIKQIIENLSELEQFDKESVQNKFKEIAAANDLKLNDIMKPVRALITGMTASPSVFEIAEILGKENILKRLKII
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUCI_SALTY
Sequence: MKKISLPKIGIRPVIDGRRMGVRESLEEQTMNMAKATAALITEKIRHACGAQVECVIADTCIAGMAESAACEEKFSSQNVGVTITVTPCWCYGSETIDMDPMRPKAIWGFNGTERPGAVYLAAALAAHSQKGIPAFSIYGHDVQDADDTSIPADVEEKLLRFARAGLAVASMKGKSYLSVGGVSMGIAGSIVDHNFFESWLGMKVQAVDMTELRRRIDQKIYDEAELEMALAWADKNFRYGEDQNASQYKRNEAQNRAVLKESLLMAMCIRDMMQGNKTLADKGLVEESLGYNAIAAGFQGQRHWTDQYPNGDTAEALLNSSFDWNGVREPFVVATENDSLNGVAMLFGHQLTGTAQIFADVRTYWSPEAVERVTGQALSGLAEHGIIHLINSGSAALDGACKQRDSEGKPTMKPHWEISQQEADACLAATEWCPAIHEYFRGGGYSSRFLTEGGVPFTMTRVNIIKGLGPVLQIAEGWSVELPKAMHDQLDARTNSTWPTTWFAPRLTGKGPFTDVYSVMANWGANHGVLTIGHVGADFITLAAMLRIPVCMHNVEEAKIYRPSAWAAHGMDIEGQDYRACQNYGPLYKR
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
What are the official names of this protein?
L-fucose isomerase, 6-deoxy-L-galactose isomerase, FucIase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END4_CHLPB
Sequence: MRYIGAHVSIAGGIENAPLRAQEIGATAFALFTKNQRQWKAPALTAKTIEAFRENCERCGYRPEHILPHDSYLINLGSPDAQKLDRSRNAFIDEMQRTEALGLVRLNLHPGSHLRESSEEACLETIAESVNLAHEATNTAVAVLENTAGQGSNLGHTFEQLAFIIQRVHDKSRVGVCLDTCHLFAAGYDLRTEEAVNGMFELFDASIGLHYLKGMHLNDAKPELDSRRDRHESIGKGKIGLDGFAAIIRHPASAEIPLILETPQPEIWSEEITLLRSFEEAQNC
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: RL20_STRZT
Sequence: MARVKGGVVSRKRRKRILKLAKGYYGAKHILFRTAKEQVMNSYYYAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVNDAVAFTALADAAKAKLGK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RR7_BIGNA
Sequence: MSRRKLSKKRIFKKDPFYNNELIQIIINRIMKKGNKALARKIIYRSLKDIELVTKQDPIKIVEQAVSNVTPFVEIRSRRLGGSTTQIPVFINNERGVTLAIRWLFQASKNKAGNKYSIIKRLSSEIVNASNGMGEAIKKRDEMHRMAEANKTIVKYNVL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ATPF_CAUSK
Sequence: MPAFFEGEFWQIANPELWVGVGLILFIAIVIWAKAPAMIAGKLDETAAKIQTDLDEAARIRAEAEALLATIRAEREETERQAIAMLAAAKADVAQMEIEAKAKLEDQIKRRAEMAERKIAQSEAQAQADVKAAAVDLAAQIAEQVLMARLAAGGSDGLVDTAIGQIGAKLQ
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ARGB_SALPB
Sequence: MNPLIIKLGGVLLDSEEALERLFTALVNYRESHQRPLVIVHGGGCVVDELMKGLNLPVKKKDGLRVTPADQIGIITGALAGTANKTLLAWAKKHHIASVGLFLGDGDSVNVTQLNEALGHVGLAQPGSPKLINMLLENGFLPVVSSIGVTDDGQLMNVNADQAATALAATLGADLILLSDVSGILDGKGQRIAEMTASKAEQLIDQGIITDGMIVKVNAALDAARALGRPVDIASWRHAEQLPALFNGTPIGTRILA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_COXBN
Sequence: MQLNDLKPAKGARHQKLRVGRGIGSGKGKTAGRGHKGQHSRAGGYHKVGFEGGQMPLQRRVPKFGFTSRKELISAEVRLGELNKISGDVVDLASLKAANIISRQIKRVKIFAAGKLEKPVTIRGLRVTKGVKAAVEAAGGKIE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: AIM36_CLAL4
Sequence: MARYKRPTSPKFQRAINMFRLVAGKRPPVRTVLSRGIPCPSFAKAFYSTPQRKIRKPEEGPKIRYLVLVVFASFGLLHFVTTQVDKKAPKNSFTEREFEQYERETGLRRRHKLINHEKNDQYAFYAVPYAHDVSKAVQLLTKMLPNEKQVKVIDPKQLIEKELEDEGKYSYLLQDLLAYKKPLPRGLITALMKQEIELFLNTTKGQFDTNILLMNYPQSTDEAIKFENDVSELKTCIVLEDDFAKSLHDDLSDDDVRKVNNVVGYFDTVGKAEKVNSKVKVLN
What are the official names of this protein?
Altered inheritance of mitochondria protein 36, mitochondrial, Found in mitochondria protein 39.
What is the protein family that this protein belongs to?
Belongs to the AIM36 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: Y1408_BACAH
Sequence: MKVIAVTGYKPFELGIFKNDHPGVECIKKALRRKLTAFVEDGLEWVIISGQLGVELWAAEVVFEIQVEYPDLKLAVFTPFLEQEEGWKEDNREYYEFILSQADHVDSITKRKYESPEQFKLKNQFFIEKSDALLAVYDEEKPGSPKYIVEAAKKKGEIENYHSYFILFSDLQDIIEEEQWNNAE
What are the official names of this protein?
UPF0398 protein BALH_1408.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: RIMP_FERNB
Sequence: MSLSQKEIIERVRAIAEPIVTSMGLELFDVKYRIQAGKWVLSIIIDKLDDYVSTRDCELVSYEIEKVLDSHDFIPGRYYLEVSSPGLDRPLKKIEDFRRFVGKLVKVKTKKTYRGYIVDVNMETKEIILRVDNENITIKYDDVKSANLEIEL
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPA1_CAEBR
Sequence: MGNCDSRELAEQTKQSKKINTELAIAKKDDENVIKLLLLGAGESGKSTVLKQMRIIHNSGFSQEESMTKRNVVCANTIQAMGALIEGMRQLRIDFVNRICNAHEKLIRETLSENTEYNPFNDAMYTALSDLWADKGIQSAYGKRELFYLADSAKYFFDSLARINEPNYIPTENDILHTRVPTMGVIEVKFQMKGKVFRVFDVGGQRSQRKKWIHCFDDAKALIYVASLSEYDQVLLEDNTTNRMQESLQLFKQVVNNKYFVNTSVILFLNKVDLFEEKIIIKKRSLTIAFDAYTGPQEDVEAAITFIDSKYRAMADNKDKNIYVHKTCATDTHQVQYVLDAVLDTILSSKLKGCGLF
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-1 subunit.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(q) subfamily.
Protein: TGFR1_RAT
Sequence: MEAASAALRRCLLLIVLVAAATLLPGAKALQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTYCCNQDHCNKIELPTTGPFSEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
What is the function of this protein?
Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.  Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.  The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2.  Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4.  The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes.  This constitutes the canonical SMAD-dependent TGF-beta signaling cascade.  Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.  For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis.  Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity).
What are the official names of this protein?
TGF-beta receptor type-1, TGFR-1, Serine/threonine-protein kinase receptor R4, SKR4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Membrane raft. Cell surface.
Protein: TM14A_BOVIN
Sequence: MDLIGFGYAALVTFGSILGYKRRGGVLSLIAGLFVGFLAGYGAYRVSNDKRDVKLSLFTAFFLATIMGVRFKRSKKIMPAGLVAGLSLLMILRLVLLLL
What is the function of this protein?
Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
What are the official names of this protein?
Transmembrane protein 14A.
What is the protein family that this protein belongs to?
Belongs to the TMEM14 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane.
Protein: CMOA_CELJU
Sequence: MTHSKTDRLYANPLAQVSQFVFDENVVDVFPDMIKRSVPGYATIINMIGNLAERYTQSGSQCYDLGCSLGAATLAMRHRIQAADCKIIGVDSSAAMLQRCAQIMAADTSDIPVDLVEARIQDVPITNASVAVLNFTLQFIPLDERQSVLNNICAGLRPNGVLILSEKLAFEDETHQQLMIDLHHNFKRANGYSDLEIAQKRTSIENYLIPETLAAHRHRLRTAGFHSVDVWFQCFNFASLIAIK
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: FEN_HYPBU
Sequence: MGVNIREVIPPEAIQEIDLAHLKYKVVAIDAYNALYQFLTAIRQPDGTPLMDSKGRITSHLSGLFYRTINLMEHGIKIVYVFDGKPPEMKYLEIERRKRVKSEAVKKYEEAVKKGDTKAARRYAQMAARLTDEMVEDAKKLLDAMGVPWVQAPAEGEAQAAFMARRGDAWAAASQDYDSLLFGSPRLVRNLAITGRRKLPRKDVYVEIKPELIELDKLLKALGITREQLVALGILIGTDYNPDGVKGIGPKTALKMVKAHRDPVKLLQGLPRHEFPTDPLKIYEYFLNPPVTTDYKLEWREPDEKKVFEILVEGHDFSPERVRNALERLKKAYREHFRGQQMGLDAWLRR
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: PUR7_SHEPW
Sequence: MNLADKVLVVNDNLPIRTDKPVHSGKVRSVYWLTPEDSARLIKDKGYDVPADAPLAIMVISDRISAFDCVWQGENGLNGVPGKGTALNAISNHWFKLFKEKGLADSHILDIPHPLVWIVQKARPVMIEAIARQYITGSMWRSYTKGEREFCGITIPEGLEKDQKLPELLITPSTKGVLTGLEGVPEADDVNVSRSDIERHVDGFNFSSLSDIDLYEKLLKEGFDVISDALAEHDQIFVDTKFEFGYVNDAAGNEKLIYMDEVGTPDSSRIWDGSSHRDGKIIEQSKEGFRQWLLNHFPDADILLNKNRMEERFALAKDNKLPESVMMDISNTYVGIAEKVIGEKLHISENPKQEIIDILRSEYQLIV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: CALL4_HUMAN
Sequence: MAAEHLLPGPPPSLADFRLEAGGKGTERGSGSSKPTGSSRGPRMAKFLSQDQINEYKECFSLYDKQQRGKIKATDLMVAMRCLGASPTPGEVQRHLQTHGIDGNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMVDKEKKGYVMASDLRSKLTSLGEKLTHKEVDDLFREADIEPNGKVKYDEFIHKITLPGRDY
What are the official names of this protein?
Calmodulin-like protein 4, Serologically defined breast cancer antigen NY-BR-20.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.