PharMolix/UniProtQA huggingface dataset:
Protein: HXK2_HORSE
Sequence: MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLAATTHPTASVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQKVEMENQIYAIPEDIMQGSGTQLFDHIAGCLANFMDKLQIKDKKLPLGFTFSFPCIQTKLDESFLVSWTKGFKSRGVEGRDVVTLIRKAIQRRGDFDIDIVAMVNDTVATMMTCGYDDQNCEIGLIVGMGSNACYMEEMRYIDTVEGDEGRMCINMEWGAFGDDGTLDDIRTEFDQEIDMGSLNPGQQLFEKMISGMYMGELVRLILVKMAKEELLFRGKLSPELLTTGRFETKDVSEIEGEKDGIQKAREVLVRLGMDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLQKTVRRLVPNCDIRFLCSEDGSGKGAAMVTAVAYRLAYQHRARLKTLEPLKLSREQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQDIMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNRLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNTEWGAFGDNGCLDDFCTEFDVAVDELSLNPGKQRFEKMMSGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALQQVRAILQHLGLESTCDDSIIVKEVCTVVAQRAAQLCGAGMAAVVDKIRENRGLDTLKVTVGVDGTLYKLHPHFAKVMRETVKDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR
What is the function of this protein?
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively).  Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate.  Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
What are the official names of this protein?
Hexokinase-2, Hexokinase type II, HK II.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane. The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein. Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis.
Protein: OVUH_LYMST
Sequence: MKMSGLLSKPDYGVVGIVFTVVFCCWCSSSTTHALSIAEPGRDRYDKRSPTGHGVEVVESGEDYGSNRPQPVYGDEDEEDSADVYVGSDESSSGEKTRLTAAKRRLRFNKRRLRASKRRLRFHKRRVDSADESNDDGFDRKAREPRLRFHDVRKRSATAEEGSENAEIEESHLGNSRSRRSAGSAPSSANEVQRSKRLSITNDLRAIADSYLYDQHKLRERQEENLRRRFLELGKRGSAFFDHIPIIFGEPQYDYQPFK
What is the function of this protein?
CDCA (or alpha-CDCP) triggers the electrical activity of the caudodorsal cells (CDCS).
What are the official names of this protein?
Ovulation prohormone.
What is the protein family that this protein belongs to?
Belongs to the molluscan ELH family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURQ_SYNS9
Sequence: MAGFDPTLQPSDDRGHLLTEQSNPRSRRLDQLATNDLVNLFVEEDRRPQEAVAEASEAIAAAVDAISKRLSSGGRLFYLGAGTSGRLGVLDAAECPPTFCSDPELVQGVLAGGTPALLRSSEGLEDLEQAGRDDLDRHGFRQGDCLVGIAAGGTTPYVRGGLSYACSIGALAIAMACVPKDQAPLPCDIDIRLLTGPELLTGSTRLKAGTATKMALNILSTTVMVRLGKVYGNRMVDVAASNSKLVDRSLRILRDLIGVEREEGLALLALSDGSVKLALLMKAANLSKDQARSVLERHDQQLRPSLETCGATLAQL
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: PUR9_GEOMG
Sequence: MAKITRALISLSDKTGIVEFARELAGYGVEILSTGGTAKLLRDAGLTVKDVSEHTGFPEMLDGRVKTLHPKVHGGLLGMRSNPEHVATMKEHGILPIDMVVVNLYPFEATVANPACTLEDAIENIDIGGPTMLRSAAKNNADVTVVVDPADYRTVLDEMKASGGSVAKETNFRLAVKVYQHTAAYDGAISNWLGARTGEGVATYSDTITLQFKKAQEMRYGENPHQSAAFYVERQVQEASVSTARQLQGKELSYNNIGDTDAALECVKQFSEGPACVIVKHANPCGVAIGKNLLEAYDRAYATDPESAFGGIIAFNGELDAETAKAICDRQFVEVIIAPSVSKAAVEVVAAKKNVRLLECGIWPAQPAQRLDFKRVNGGLLVQDTDLALSAELKVVSKRQPTAQEMIDLQFAWRVAKFVKSNAIVYGKDGMTIGVGAGQMSRVNSARIAAIKAEHAGLEVQGAVMASDAFFPFRDGIDNAAAVGITAVIQPGGSMRDAEVIAAADEHGMAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: SYP_SHEWM
Sequence: MRVSKYLLSTQKETPADAEVISHQLMLRAGMIRRNASGLYSWLPTGLRVLRKIEAIVREEMNKAGSVEILMPMVQPADLWVETGRFEKFGPELLRFQDRHNRDFVLGPTHEEVITDIVRKEVNSYKQLPLNLFQIQTKFRDEVRPRFGVMRSREFLMKDAYSFHLDQETMDETYESMFQAYSNILTRLGLAFRPVIADTGSIGGSMSHEFHVLANSGEDLIAYSTGSDYAANIEKAESPMPTQTRGEATQEMSLVDTPNAKTIAELVEQHGVAIEKTVKTLIVKGSSEEAPLVALVIRGDHDLNEVKAEKIPAVHAPFEFADEADIRKAVGAGPGSIGPVGLEIPVYIDHGVSVMSDFAAGANQDNKHLFGINWERNLPQAEAFDLRNIIEGEASPCGQGTIALLRGIEVGHIFQLGKNYSEAMNANVLDQNGKAQTLLMGCYGVGVSRMVAAAIEQNHDDRGIIWPDAIAPFRVGILPMNMHKSHRVQDMAEQLYKDLSDAGIEVLFDDRKERAGVMFADMELIGLPHVVVIGDRNIDAGVFEYKNRRTGEKQEVPFDQIVEFLKSAQ
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSP_SALTI
Sequence: MTQTLSQLENRGAFIERHIGPDAAQQQEMLNAVGAESLNALTGQIVPKDIQLATPPQVGEAATEYAALAELKAIAGRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVAADVHPQTLDVVRTRAKTFGFDVIVDDADKVLDHQDVFGVLLQQVGTTGEIHDYGTLISELKARKVIVSVAADFMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEFKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVYHGPVGLKRIANRIHRLTDILAAGLQQKGLKLRHAHYFDTLCVEVADKAAVLARAEAAEINLRSDIHNAVGITLDETTTRENVAQLFNVLLGDSHGLNIETLDKDVALDSRSIQQGMLRDDAILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYHQMISQLSDWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHGSRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLDDLRAKAEQHAANLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKQASQVAILNANYIASRLKDAYPVLYTGRDGRVAHECILDIRPLKEETGISELDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESEGKAELDRFIDAMLAIRAEIDQVKAGVWPLEDNPLVNAPHIQSELVAEWAHPYSREVAVFPAGVADKYWPTVKRLDDVYGDRNLFCSCVPISDYQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: SYDND_HELPY
Sequence: MRSHFCTEISEKDVGKIVKVAGWCNTYRDHGGVVFIDLRDKSGLVQLVCDPSSKAYEKALEVRSEFVLVAKGKVRLRGAGLENPKLKTGKIEIVLEELIIENKSATPPIEIGNKHVNEDLRLKYRYLDLRSPNSYEIFKLRSEVALITRNTLAQKGFLEIETPILSKTTPEGARDYLVPSRVHEGEFFALPQSPQLFKQLLMVGGMDRYFQIARCFRDEDLRADRQPEFTQIDAEMSFCDENDVMGVVEDLLQEIFKAVGHTISKPFKRMPYKEAMENYGSDKPDLRFELPLIEVGDCFRDSSNAIFSNTAKDPKNKRIKALNVKGADALFSRSVLKELEEFVRQFGAKGLAYLQIKEDEIKGPLVKFLSEKGLKNILERTDAQVGDIVFFGAGDKKIVLDYMGRLRLKVAETLDLIDKDALNFLWVVNFPMFEKTENGYHAAHHPFTMPKNIECEDIEEVEAHAYDVVLNGVELGGGSIRIHKEEMQKKVFEKINIHEEEAQKKFGFLLEALKFGAPPHGGFAIGFDRLIMLMTKSHSIRDVIAFPKTQKASCLLTNAPSPINEEQLRELHIRLRK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Is 1. 7 times more efficient at aminoacylating tRNA(Asp) over tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSTC_HUMAN
Sequence: METLYRVPFLVLECPNLKLKKPPWLHMPSAMTVYALVVVSYFLITGGIIYDVIVEPPSVGSMTDEHGHQRPVAFLAYRVNGQYIMEGLASSFLFTMGGLGFIILDRSNAPNIPKLNRFLLLFIGFVCVLLSFFMARVFMRMKLPGYLMG
What is the function of this protein?
Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667).  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.  May be involved in N-glycosylation of APP (amyloid-beta precursor protein).  Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
What are the official names of this protein?
Oligosaccharyltransferase complex subunit OSTC, Hydrophobic protein HSF-28.
What is the protein family that this protein belongs to?
Belongs to the OSTC family.
Protein: HHA_SALTS
Sequence: MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
What is the function of this protein?
Binds to H-NS and modifies the range of genes it silences; H-NS alone silences 'core' genes while the H-NS-Hha complex (and presumably also H-NS-YdgT) silences genes acquired by horizontal gene transfer (PubMed:19521501).  Plays a role silencing virulence factors in the absence of factors that induce pathogenicity (PubMed:17307861).  Probably requires H-NS to bind DNA (By similarity).
What are the official names of this protein?
Hemolysin expression-modulating protein Hha.
What is the protein family that this protein belongs to?
Belongs to the Hha/YmoA/Cnu family.
Protein: KPTA_PSEA7
Sequence: MDRKTLDDTSRFLSHVLRHQPEAIGLTLDGEGWADIDALIAGAARDGRALDRALLGAVLRSNDKQRFAFSADGQRIRAVQGHSHAAVAIAYAPAVPPAVLYHGTARRFLDSIREHGLVPGSRHHVHLSARRATALEVGRRYGSPVLLEVDARDMHLAGHLFHQAENGVWLAGQVPVRFIREA
What is the function of this protein?
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P).  May function as an ADP-ribosylase.
What are the official names of this protein?
Probable RNA 2'-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: HBA_CROSI
Sequence: VLSSDDKCNVKAVWCKVAGHLEEYGAEALERMFCAYPQTKIYFPHFDLSHGSAQIRAHGKKVFAALHEAVNHIDDLPGALCRLSELHAHSLRVDPVNFKFLAQCVLVVVAIHHPGSLTPEVHASLDKFLCAVSSVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.  Has antimicrobial activity against B. subtilis ATCC 6633.  Has antioxidant activity.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RL7_SULNB
Sequence: MATTKEDVLEFISNLSVLELSELVKEFEEKFGVTAQATVVAAGGAAAGGEAAEEQTEFNVVLTDAGAKKINAIKVVRAITGLGLKEAKAAVEETPTVLKEGVSKEEAEEFKKQIEEAGASCELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: CUEDA_CONCL
Sequence: MKLCVVIVLLMLAMPFNGGEASRFFNQHARSQRSGMKTRGIWCDPPCPKGETCRGGECSDEFNSDVGR
What is the function of this protein?
Probable neurotoxin with unknown target.  Possibly targets ion channels.
What are the official names of this protein?
Conotoxin Cal14.13a, Conotoxin Cal14.1a.
What are the subcellular locations of this protein?
Secreted.
Protein: TATB_AERS4
Sequence: MFDIGFWELVVIGIVALVVLGPERLPVAIRTASHWIRLIRSTANSVKSELEQELRLQELHNDLKKAEQLQMSNLSPELQESIEQLKAAAQSVTRPYEQQNTIHPAPAAAEVKAEPAQPAAAMTHDEAPMVTTVQSTDVLADKKEEVKP
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RNKB_XENLA
Sequence: MVSLLCCGPKLAACGIVLSVWGVIMLVLLGVFFNVHSAVLIEDVPFTEADMFEDPNPPAKMYRLYEQVSYNCFIAAAIYIVLGGFSFCQVRLNKRKEYMVR
What is the function of this protein?
Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds.
What are the official names of this protein?
Ribonuclease kappa-B, RNase K-B, RNase kappa-B.
What is the protein family that this protein belongs to?
Belongs to the RNase K family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PYND_ASPNC
Sequence: MWRIPVIVALVAGLLYWVRKQGSQPSRKIPQPRIGLPVVGDAHAFGKSPISYIRQATARCGPVFQINLLLTKIVMLRGAQLNRFYLDTREEVWSFGDGMGLFLEKVVVPGYLSHLKEMVSSLNRGVIRSIALEHYTRIAGEEARKIATNWAEKPDIEVFEQMSRYTHRVIVRCLMGQDFYDHHLDELLDLLHRMEADIGHPFHFLLPNWVPHGPARRLHHARDRMAAIFNERLQAREQNPEKWQDSLDYIAYTLKDSRTAHLRQYFAAHHTLLMFAAHTSTVASIAWTVLELLRNPTHLEALKTALATDADIHRSPTLIATLKETSRRYSGVNMIRWARQPHQLPADAAPGKGNIVVPENCIVSISPYLTHHDPETYADPHIWDPTRWLEGGRLSETQKSNRSEVTYFPFGAGCHRCPGEQMAGMIAREMVAHMVKTYDVRWSSTGPPEDFEQLDFSRVGSAWLKGDARVTVKRDKQGMEEA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of pyranonigrins, a family of antioxidative compounds (PubMed:24106156, PubMed:26414728).  The first step of pyranonigrins biosynthesis is performed by the hybrid PKS-NRPS synthetase that condenses 6 malonyl-CoA units to an acetyl starter unit, to form a 1,3,5-trioxotetradecane-6,8-dienyl-ACP (PubMed:24106156).  The enoyl reducrase (ER) domain of pynA is likely to be functional during the first two rounds of polyketide chain extension, to generate the saturated C-C bonds of the alkyl side chain (Probable).  PynA subsequently forms the amide bond between the acyl chain and L-serine (PubMed:24106156, PubMed:26414728).  Although pynA has a terminal reductase domain, it appears to require the thioesterase pynI for the release of the straight-chain intermediate from pynA via the formation of a tetramic acid pyranonigrin J (PubMed:26414728).  The methyltransferase pynC then coverts pyranonigrin J to pyranonigrin I via N-methylation (PubMed:26414728).  The FAD-dependent monooxygenase pynG catalyzes an epoxidation-mediated cyclization to form the dihydro-gamma-pyrone moiety, followed by pynD-catalyzed oxidation of the alcohol to the ketone and enolization to yield the characteristic tetramic acid-fused gamma-pyrone core of pyranonigrin H (PubMed:26414728).  Pyranonigrin H is substrate of pynH for dehydration-mediated exo-methylene formation from the serine side chain to produce pyranonigrin E, before the oxidase pynE reduces the exo-methylene of pyranonigrin E into a pendant methyl to form pyranonigrin G (PubMed:26414728).  The FAD-linked oxidoreductase pynB performs the reverse reaction and converts pyranonigrin G back to pyranonigrin E (PubMed:26414728).
What are the official names of this protein?
Cytochrome P450 monooxygenase pynD, Pyranonigrin biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: RISB_SHESW
Sequence: MNIVQGNIEAKNAKVAIVISRFNSFLVESLLEGALDTLKRFGQVSDDNITVVRVPGAVELPLAARRVAASGKFDGIIALGAVIRGGTPHFDFVAGECNKGLAQVALEFDLPVAFGVLTTDTIEQAIERSGTKAGNKGGEAALSLLEMVNVLQELEQQL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: PHSL_DESBA
Sequence: MSQAATPAADGKVKISIDPLTRVEGHLKIEVEVKDGKVVDAKCSGGMFRGFEQILRGRDPRDSSQIVQRICGVCPTAHCTASVMAQDDAFGVKVTTNGRITRNLIFGANYLQSHILHFYHLAALDYVKGPDVSPFVPRYANADLLTDRIKDGAKADATNTYGLNQYLKALEIRRICHEMVAMFGGRMPHVQGMVVGGATEIPTADKVAEYAARFKEVQKFVIEEYLPLIYTLGSVYTDLFETGIGWKNVIAFGVFPEDDDYKTFLLKPGVYIDGKDEEFDSKLVKEYVGHSFFDHSAPGGLHYSVGETNPNPDKPGAYSFVKAPRYKDKPCEVGPLARMWVQNPELSPVGQKLLKELYGIEAKKFRDLGDKAFSIMGRHVLVAEETWLTAVAVEKWLKQVQPGAETYVKSEIPDAAEGTGFTEAPRGALLHYLKIKDKKIENYQIVSATLWNANPRDDMGQRGPIEEALIGVPVPDIKNPVNVGRLVRSYDPULGCAVHVLHAETGEEHVVNID
What are the official names of this protein?
Periplasmic [NiFeSe] hydrogenase large subunit, NiFeSe hydrogenlyase large chain.
What is the protein family that this protein belongs to?
Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
What are the subcellular locations of this protein?
Periplasm.
Protein: LYS7_CAEEL
Sequence: MAHKSIVIFSVLAVLCHSASVKVPPIVDSSLPVKFSEVIAEPAPNVPSNLASYAYALDIYVQTTLSQLQCIKQAGYCAVFVRAYNPAGQGSFDTSSCVTIQNAYKAGLGIEIYMTPQPVSNKQGYQQLDEIIQGLTARAITVRAIWIQVTSPTNWPNNANSNINFINSIVSRARQSGLTVGIYTSYYDWNQITTGWSNIGNDVLLWYWNVYSGGVTGETPANFNDFRKFGCWTAPSVKQFAQDETVCGITVNRDVYLAGNVLKAVEEDGKIYAGGFVQGSLKI
What is the function of this protein?
Plays a role in resistance to Gram-positive bacteria B. thuringiensis and M. nematophilum and Gram-negative bacteria S. boydii or S. flexneri infection and to fungus C. neoformans infection (PubMed:16809667, PubMed:21399680, PubMed:21931778, PubMed:22841995).  Plays a role in susceptibility to Gram-negative bacterium S. typhimurium infection (PubMed:21399680).
What are the official names of this protein?
Lysozyme-like protein 7.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 25 family.
Protein: RPOA_LARHH
Sequence: MQNSASEFLKPRLIDVQPVSATQARVAMEPFERGYAYTLGNALRRILLSSMPGFAPTEVSIAGVLHEYSALDGVREDVVDILLNLKGVVFKLHGRDSVLLTLKKEGEGAVRASDIDLPHDVEVVNPDHVICHLAAGGKIDMEIKVEKGRGYQPAPARVKQDDNRQIGTILLDASFSPLRRVSFSVESARVEQRTDLDRLVMDIETNGVIEPEEAVRSAARILIDQLSIFADLQGTTVEVVEERAPQVDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTETELLKTPNLGRKSLNEIKEVLASKGLTLGMKLENWPPAGLEKP
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: AIM4_YEAST
Sequence: MDQKKDPSNNLTERRVSKVQRPNKKKVRNQVESLSRNLERNKEGQLLQTVSKGHLEADSGHSLGREKENGELGIRSIFYDKDWNPRGTAPSHYRNIPYNPATFKRRTEVQARLGNLENIKIPK
What are the official names of this protein?
Altered inheritance of mitochondria protein 4, Synthetic with old yellow enzyme protein 1.
What is the protein family that this protein belongs to?
Belongs to the AIM4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_AZOSB
Sequence: MQFELLSTSAGARRGRLTLAHGAVETPVFMPVGTYGTVKAMTPAMLSDVGAQICLGNTFHLWLRPGLDIVGAHGGLHRFMGWDKPILTDSGGFQVFSLGALRKISEEGVKFASPIDGARLFLTPEISMQIQTVLNSDVVMIFDECTPYPATRDEAAKSMRLSRRWARRSRDEFDRLENANALFGIVQGGMYEDLRDESLGALQDIGFHGFAIGGLSVGEPKDDMARILAHTAPRLPADKPRYLMGVGTPEDIVDGIANGIDMFDCVMPTRNARNGWLFTRYGDLKIKNAVHKADTRPLDPSCSCYTCRNFSRSYLHHLHRAGEILGSMLNTVHNLHYYQTLTAELRDAIAADRFADYVTRFRSERATGAH
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: WDR91_RAT
Sequence: MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAALRDYWSYLERRLFSRLEDIYRPTINKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIISLHNFLSVLFQCMPVPVILNFDAECQRTNQVQEENEVLRQKLFALQAEVHRLKKEEQQQEEAAALVQHKLPPYVSSMDRLGDSELALVCSQRPASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQAQSSAKKDTFSSQATKGKDPVPGAKDGKSLLSGPVPGEASWTHQRQRRLQDHGKERRELLSTSSSQTQCAEKKLEGSGPEAELCLDLHMGPVEALARVSTAGSEGDRPEQPFIVLSQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDDMPRILSLACSPNGASFVCSAAAPSLTSQPDSSAPDIGSKGMNQVPGKLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHGCAMSWKAHCGEVYSVEFSYDENAVNSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGLIYKLGSEEKVLENCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKL
What is the function of this protein?
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex.  By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport.  It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome.  May play a role in meiosis.
What are the official names of this protein?
WD repeat-containing protein 91.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR91 family.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein. Late endosome membrane.
Protein: RL14_METHJ
Sequence: MKGLGIKVPRAVSTGTKLTCADNTGARVVQVVSVFGYHGVRRRQPKLGLADIATVSVKKGTPDMRRKLVRAVVIRQKKEIRRPSGLRLSFEDNAVVVVDDKNEPRGTEIKGPVAREVAIRYPRIGSMATIIV
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.