PharMolix/UniProtQA huggingface dataset:
Protein: CHEB1_SHESR
Sequence: MAIKVLVVDDSSFFRRRVSEIVNQDPELEVIATASNGAEAVKMAAELNPQVITMDIEMPVMDGITAVREIMAKCPTPILMFSSLTHDGAKATLDALDAGALDFLPKRFEDIATNKDDAILLLQQRVKALGRRRIFRPVVRPSTPTPTPRSSASSVLGGVSTHTQPAPAPVRSSHAASIRPSGKQYKLLLIGTSTGGPVALQKILTQFPANYPHPILLIQHMPAAFTPAFANRLNGLCKIEVKEAVNGDVLRPGCAYLAPGGMQMMVERTGVTGRVKVLAGSAEMNYKPCVDITFASASKAFGGDVLAVVLTGMGADGREGARMLKSAGATIWAQDEASCVVYGMPQAVASAGIATQSISLDNMAESILKESARG
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 1.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCM5_DROME
Sequence: MEGFDDAGVFFSDNFGGDNQQDAQINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGEENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMKVIHTMIRRGELQHRMQRKMLYRIC
What is the function of this protein?
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
What are the official names of this protein?
DNA replication licensing factor Mcm5, Minichromosome maintenance 5 protein, DmMCM5.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: RS6_FUSNN
Sequence: MRKYEIMYIINPTVLEEGREELVNQVNALLTSNGATIAKTEKWGERKLAYPIDKKKSGFYVLTTFEIDGTKLAEVESKLNIMESVMRYIVVKQD
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: REV1_MOUSE
Sequence: MRRGGWRKRTENDGWEKWGGYMAAKVQKLEEQFRTDAANQKDGTASAIFSGVAIYVNGYTDPSAEELRNLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKAGRLLSSAPYQLYTKPSAAQKSLNFNPVCKPEDPGPGPSNRAKQLNNRVNHIIKKIETESEVKANGLSSWNEDGVNDDFSFEDLEHTFPGRKQNGVMHPRDTAVIFNGHTHSSNGALKTQDCLVPVGNSVASRLSLDSTQEEKRAEKSNADFRDCTVQHLQHSTRSADALRSPHRTNSLSPSLHSNTKINGAHHSTVQGPSSTKSTSVLTLSKVAPSVPSKPSDCNFISDFYSRSRLHHISTWKCELTEFVNTLQRQSSGIFPGREKLKKVKTGRSSLVVTDTGTMSVLSSPRHQSCVMHVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGTAPLRPGANPQLEWQYYQNRALRGKAADIPDSSVWENQDSTQTNGIDSVLSKAEIASCSYEARQVGIKNGMFFGYAKQLCPNLQAVPYDFHACREVAQAMYETLASYTHSIEAVSCDEALIDVTDILAETKLSPEEFAAALRIEIKDKTKCAASVGIGSNILLARMATKKAKPDGQYHLQPDEVDDFIRGQLVTNLPGVGRSMESKLASLGIKTCGDLQCLTMAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEEIQRRLEAAGMKGKRLTLKIMVRKPGAPIETAKFGGHGICDNIARTVTLDQATDSAKIIGKATLNMFHTMKLNISDMRGVGIQVNQLVPANSNLSTCSSRPSAQSSLFSGRPHSVRDLFQLQKAKKPTEEEHKEVFLAAVDLEVSSTSRACGLLSPLSAHLAASVSPDTNSGECSRKWNGLHSPVSGQSRLNLSIEVPSPSQIDQSVLEALPLDLREQIEQVCAAQQGEPRGKKKEPVNGCSSGVLPHPVGTVLLQIPEPQEPCNSDSKISVIALPAFSQVDPDVFAALPAELQKELKAAYDQRQRQGEDTTHQQPTSTSVPKNPLLQLKPPAMKDKRNKRKNLIGSPRKSPLKNKLLSSPAKTLPGAYGSPQKLMDGFLQHEGMASERPLEEVSASTPGAQDLSSLLPGQSSCFRPAAPNLAGAVEFSDVKTLLKEWITTISDPMEEDILQVVRYCTDLIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT
What is the function of this protein?
Deoxycytidyl transferase involved in DNA repair.  Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction.  May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion.  Required for normal induction of mutations by physical and chemical agents.
What are the official names of this protein?
DNA repair protein REV1, Rev1-like terminal deoxycytidyl transferase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL5_PAEAT
Sequence: MTETLETPVKIVPRLKTKYAETIKKSLQDEFSYANVNQVPRLVKVVVNMGVGDAAKDSKLIDGAVRDLTLITGQKPQVTKARKSIAQFKLREGMPIGAHATLRGDRMWEFVDRLVSLALPRIRDFRGLNGKQFDGNGNYTFGLTEQVMFHEIDQDSIDRVRGMDITVVTTAKTDDEGRALLKALGFPFKTEN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ENV_MLVKI
Sequence: RRARYKKEPVSLTLALLLGGLTMGGIAAGVGTGTTALVATQQFQQLQAAIHDDLKEVEKSITNLEKSLTSLSEVVLQNRRGLDLLFLKEGGLCAALKEECCFYADHTGLVRDSMAKLRERLSQRQKLFESQQGWFEGLFNKSPWFTTLISTVMGPLIILLLILLFGPCILNRLVQFIKDRISVVQALVLTQQYHQLKTIGD
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the virion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity). SUBCELLULAR LOCATION: [R-peptide]: Host cell membrane; Peripheral membrane protein. Note=The R-peptide is membrane-associated through its palmitate.
Protein: PDRP1_STAEQ
Sequence: MDNIKIIVASDSIGETAELVARAGVSQFNPKQCKHEFLRYPYIESFENVDEVIQVAKDTNAIIVYTLIKPEIKKYMISKVNEHALKSVDIMGPLMELLSNSIEETPYYEPGMVHRLDDAYFKKIDAIEFAVKYDDGKDPKGLPKADIVLLGISRTSKTPLSQYLAHKSYKVMNIPIVPEVTPPDGLFNVDPSKCIALKISEEKLNRIRKERLKQLGLGDKARYATEARIQEELDYFEKLVDKIGCPVIDVSDKAIEETANDIIHFIEQNKSK
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein 1, PPDK regulatory protein 1.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: RS8_ECOSE
Sequence: MSMQDPIADMLTRIRNGQAANKAAVTMPSSKLKVAIANVLKEEGFIEDFKVEGDTKPELELTLKYFQGKAVVESIQRVSRPGLRIYKRKDELPKVMAGLGIAVVSTSKGVMTDRAARQAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RAP1B_CYPCA
Sequence: MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPIILVGNKCDLEDERVVGKEQGQNLARQWNSCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSTCQLL
What is the function of this protein?
Probable GTP-binding protein that possesses GTPase activity.  May play a role in endothelial cell polarity and endothelial barrier function (By similarity).
What are the official names of this protein?
Ras-related protein Rap-1b.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol.
Protein: HCP_ECO5E
Sequence: MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAVKAREYGIINHDVDSFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCLAVDANARVDNPMADLQLVSDDLGELQRQAAEFTPNKDKAAIGENILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNALLECSMEIGQMNFKVMSILDAGETGKYGHPTPTQVNVKATAGKCILISGHDLKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQQVEFARFPGPIVMTSNCIIDPTVGAYDDRIWTRSIVGWPGVRHLDGEDFSAVIAQAQQMAGFPYSEIPHLITVGFGRQTLLGAADTLIDLVSREKLRHIFLLGGCDGARGERHYFTDFATSVPDDCLILTLACGKYRFNKLEFGDIEGLPRLVDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIVTGPTAPGFLTPDLLAVLNEKFGLRSITTVEEDMKQLLSA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_HELPY
Sequence: MPSVLENILKDKLLEVSDLKKNHALPININPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLKITKTYEKFASCISVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQIKLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEVSNQQEIEHLLKLQYDIIGINNRDLHTLKTDINHTLKLRPLLPKDALIISESGIYSHAQIKALAPYVNGFLVGSSLMKEKDLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKDSIKKIQKIVKKLDLKAVQLYGYSQKEIAQLKKALPKTCAIWQVISVMSAKDLVPKTKEASLILYDTKGDKMGGNGVSFDWEILENVKTPFMLAGGLNLDNIQKALKVEALGLDFNSGLEISPGIKNKDKIKRLARILREY
What is the function of this protein?
Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway.  The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
What are the official names of this protein?
Tryptophan biosynthesis protein TrpCF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the TrpF family.
Protein: SDHB_DANRE
Sequence: MAAVCFSLSRCCSAVHRPAVTAVRFAQTAAAPAAQPRIKKFQIYRWDPDTVGDKPRMQTYEIDLNTCGPMVLDALIKIKNEMDSTLTFRRSCREGICGSCAMNINGGNTLACLNKIDTNTSKVTKIYPLPHMYVVKDLVPDMSNFYAQYKSIEPYLKKKDESQQGKQQYLQSVEDRQKLDGLYECILCACCSTSCPSYWWNADKYLGPAVLMQAYRWMIDSRDDFTEDRLSKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMVTYKQKDAVAA
What is the function of this protein?
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Iron-sulfur subunit of complex II, Ip.
What is the protein family that this protein belongs to?
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RICKA_RICBR
Sequence: MAKITELDHHLNQEKEALDKVVSNLNELCEHNQKLQGFIEIQKEVKELKKEHIKSLSWFKKLINTVSNIKYVFVKSEEQLAKDAIEQNNKLLKRIDNTILSVADKSGPLKQELQKELRKNFENLAKKDLSKDQRERLSNLLNNEYAANPQKFAQLPMSKPLHFPNAEELENQHNDLKVIQQNVLNLLTENSNIEELKKIQKQVAEIREEVPFTKLEKLNNFWQKIKNIFVNNSEQVLAKNKENNTKTIINIEEKLHKANNKFFELVSNKKQDIENIISNLPDSKRLEAIKEKLQKHINVKDTNNIAEQASAAQLQSAETKPTAVVLPNNAIPTTPPVTEEKTFTPPPAPPPPMPTDNIPTPLPVSKAEATEHKNVETAASNVPPPPPPPMPTGNVPPPPPVGDNTVTSTPQKAKETNQPRPAVDTTNLMKQIQGGFNLKKIEYGEDGKPIPKNKEDTKETSDPIIAALNKIRSAKVSSDSERSNSDSGTDSGWASDVSTRSKKVLTRRERNAKQSQQR
What is the function of this protein?
Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.
What are the official names of this protein?
Arp2/3 complex-activating protein rickA, Actin polymerization protein rickA.
What are the subcellular locations of this protein?
Cell surface.
Protein: DEOC_LATSS
Sequence: MNLAKYIDHTLLKPEATMTQVDQIIAEAKTYQFASVCLNPYWVKRASEALQDSDVKVVTVIGFPLGATTTATKVFEAQAAIENGADELDMVINVGELKAGHDEQVLSDIQAVVKAGHAAQKHVKVIIETCLLSDVEKRRACELSEKAGADFVKTSTGFSTGGATVADVTLMRSVVGDRLGVKASGGIHSKEDAEAMIAAGANRLGASAGVKIMNSK
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALM_YEAST
Sequence: MSSNLTEEQIAEFKEAFALFDKDNNGSISSSELATVMRSLGLSPSEAEVNDLMNEIDVDGNHQIEFSEFLALMSRQLKSNDSEQELLEAFKVFDKNGDGLISAAELKHVLTSIGEKLTDAEVDDMLREVSDGSGEINIQQFAALLSK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.  Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: SECB_PROMH
Sequence: MSEQQNQEMTFQIQRIYTKDISFEAPNAPQVFQKEWQPEVKLDLDTSSNTLAENVYEVILRVTVTATMEEETAFLCEVQQAGIFTVEGIEGTQLAHCLGAYCPNVLFPYARECITNLVGRGTFPQLNLAPVNFDALFMNYLQQQQQQDAANSGVEEA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISC2A_DICDI
Sequence: MIGRISSKTTALFICDIQTSFLKTVTQIEELIINNKSLMDSCLEFKIPIIMTQHDKNLFGEIVEPLRYSSSSSSSLSNVMVFDKIAYSMYTKELAQYVKENLPNLKSVILTGLESHVCVLQTALDLLENGYEVHVIDDATTSVQPKEYKSSLKRMKQSGVFLTSTETVIYQILQSDNHPKFKKIDELIVKRLFQINNINK
What are the official names of this protein?
Isochorismatase family protein 2A.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family.
Protein: KAS1_STRVN
Sequence: MTRRVVITGVGVRAPGGSGTKEFWDLLTAGRTATRPISFFDASPFRSRIAGEIDFDAVAEGFSPREVRRMDRATQFAVACTRDALADSGLDTGALDPSRIGVALGSAVASATSLENEYLVMSDSGREWLVDPAHLSPMMFDYLSPGVMPAEVAWAAGAEGPVTMVSDGCTSGLDSVGYAVQGTREGSADVVVAGAADTPVSPIVVACFDAIKATTPRNDDPAHASRPFDGTRNGFVLAEGAAMFVLEEYEAAQRRGAHIYAEVGGYATRSQAYHMTGLKKDGREMAESIRAALDEARLDRTAVDYVNAHGSGTKQNDRHETAAFKRSLGEHAYAVPVSSIKSMGGHSLGAIGSIEIAASVLAIEHNVVPPTANLHTPDPECDLDYVPLTAREQRVDTVLTVGSGFGGFQSAMVLHRPEEAA
What are the official names of this protein?
Granaticin polyketide putative beta-ketoacyl synthase 1, ORF1.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Protein: F120A_HUMAN
Sequence: MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNIELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHVPPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDSAYFPGSSTSSSSDNDEGSGGATNHISGNKIGWEKTGSHSEPQARGDPGDQTKAEGSSTASSGSQLAEGKGSQMGTVQPIPCLLSMPTRNHMDITTPPLPPVAPEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEANKDLPPAALLYRPVRQYVYGVLFSLAESRKKTERLAFRKNRLPPEFSPVIIKEWAAYKGKSPQTPELVEALAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIENLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQADQAAKVEKMRQSVLEGLSFSRQSHTLPFPPPPALPFYPASAYPRHFGPVPPSQGRGRGFAGVCGFGGPYGETVATGPYRAFRVAAASGHCGAFSGSDSSRTSKSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAASAEEVAKELKSKSGESKSSAMSSDGSLAENGVMAEEKPAPQMNGSTGDARAPSHSESALNNDSKTCNTNPHLNALSTDSACRREAALEAAVLNKEE
What is the function of this protein?
May participate in mRNA transport in the cytoplasm (By similarity).  Critical component of the oxidative stress-induced survival signaling.  Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase.  Binds RNA and promotes the secretion of IGF-II.  May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.
What are the official names of this protein?
Constitutive coactivator of PPAR-gamma-like protein 1, Oxidative stress-associated Src activator, Protein FAM120A.
What is the protein family that this protein belongs to?
Belongs to the constitutive coactivator of PPAR-gamma family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to plasma membrane upon ultraviolet exposure.
Protein: AMRP_MOUSE
Sequence: MAPRRERVSTLPRLQLLVLLLLPLMLVPQPIAGHGGKYSREKNEPEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVEGLDKDGEKEAKLIHNLNVILARYGLDGRKDAQMVHSNALNEDTQDELGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIQEYNVLLDTLSRAEEGYENLLSPSDMAHIKSDTLISKHSELKDRLRSINQGLDRLRKVSHQGYGSTTEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL
What is the function of this protein?
Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.
What are the official names of this protein?
Alpha-2-macroglobulin receptor-associated protein, Alpha-2-MRAP, Heparin-binding protein 44, HBP-44, Low density lipoprotein receptor-related protein-associated protein 1, RAP.
What is the protein family that this protein belongs to?
Belongs to the alpha-2-MRAP family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment lumen. Golgi apparatus, cis-Golgi network. Golgi apparatus lumen. Endosome lumen. Cell surface. Note=May be associated with receptors at the cell surface.
Protein: RL14_BLOFL
Sequence: MIQERTILNVADNSGARFAMCIKVLGGSKRRYANIGDVIKVTVKEAIPKAKVKKGDVLQAVIVRTKKGIRRIDGSIIRFDNNACVLLNDTNMQPLGTRIFGPVTRELRYANFVRIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: THII_SACS2
Sequence: MLVIIRPSGEIALKSPRSRRNFEYTLINNIRNTIGGGKIWRSQGVILLEVNDNNANIEALSEVFGISSFSPVIAIKSNNLEDIVNKAKEIFAEIVKGKIFAVRAKRIGSHSFTSLDVERRAGEALYPYSKGVDLENPEVEIFIEIRNEMTYFYHKVIKGPKGLPVGVAGKTVVLFSGGIDSPVATWMMMKRGSVPIILNFNLGGDLHKELVLKELNMLKRWSGGHKLKIFIVKGTDVFIKLSQVERRSRVVMLKRVMYKTAEKLCEKTNAKSITTGESLSQVSSQTMANLYVTEYGIKYPIFRPLIGFDKEEIVDIARKIGTYKHSIKLPEYCAISTKARTSEDLNEILKNEERLNVDYEKILENSEVIEL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRP_ECOLI
Sequence: MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR
What is the function of this protein?
Among the targets of CRP is the spf gene which encodes the dual-function sRNA Spot 42; spf expression is repressed by CRP (PubMed:2454912).  Spot 42 base pairs with and represses expression from a number of mRNAs encoding proteins involved in the uptake and catabolism of nonpreferred carbon sources.  CRP and Spot 42 coregulate at least 14 operons involved in cellular metabolism, forming a coherent feedforward loop (PubMed:21292161).  Interaction with SpfP, encoded within the Spot 42 RNA, reinforces this feedforward loop (PubMed:35239441).
What are the official names of this protein?
DNA-binding transcriptional dual regulator CRP, Catabolite activator protein, CAP, Catabolite gene activator, cAMP receptor protein, CRP, cAMP regulatory protein, cAMP-activated global transcriptional regulator CRP.
Protein: ALG13_SCHPO
Sequence: MNAFVTVGSTQFDDLIRAVLKPEFQHCLVKHGINQLIVQYGKGKQAFGDPKSVAGLTILGFDYAPEIESYIHDASIVISHAGAGSILQTLRSGKRLLVVPNESLMDNHQVELATKLASMNYLVTCSTSNLVEGLEELYPKILTPFPKSDCSTFQKVMQDVAR
What is the function of this protein?
Involved in protein N-glycosylation.  Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity).
What are the official names of this protein?
UDP-N-acetylglucosamine transferase subunit alg13, Asparagine-linked glycosylation protein 13.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.