PharMolix/UniProtQA huggingface dataset:
Protein: Y2666_MYCBP
Sequence: MVVRSILLFVLAAVAEIGGAWLVWQGVREQRGWLWAGLGVIALGVYGFFATLQPDAHFGRVLAAYGGVFVAGSLAWGMALDGFRPDRWDVIGALGCMAGVAVIMYAPRGH
What are the official names of this protein?
UPF0060 membrane protein BCG_2666c.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 3098B_MYCTU
Sequence: MTATIGFRPTEKDEQIINAAMRSGERKSDVIRRALQLLEREVWIKQARTDAERLRDEDVSTEPDAW
What is the function of this protein?
Putative antitoxin component of a possible type II toxin-antitoxin (TA) system.  May neutralize the effect of cognate toxin Rv3098A/RVBD_3098A.
What are the official names of this protein?
Putative antitoxin Rv3098B/RVBD_3098B.
Protein: O10G8_HUMAN
Sequence: MSNASLLTAFILMGLPHAPALDAPLFGVFLVVYVLTVLGNLLILLVIRVDSHLHTTMYYFLTNLSFIDMWFSTVTVPKLLMTLVFPSGRAISFHSCMAQLYFFHFLGGTECFLYRVMSCDRYLAISYPLRYTSMMTGRSCTLLATSTWLSGSLHSAVQAILTFHLPYCGPNWIQHYLCDAPPILKLACADTSAIETVIFVTVGIVASGCFVLIVLSYVSIVCSILRIRTSEGKHRAFQTCASHCIVVLCFFGPGLFIYLRPGSRKAVDGVVAVFYTVLTPLLNPVVYTLRNKEVKKALLKLKDKVAHSQSK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 10G8, Olfactory receptor OR11-282.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OGG1_SULIK
Sequence: MLRSLVQNPRVRARVLERVDEFRLNNLSNEEVWFRELTLCLLTANSSFISAYQALNCLGDKIYYANEEVIRSILKSCKYRFYNLKAKYIIMAREKVYGKLKEEITPLADSDQQLAREKLLNIKGIGMKEASHFLRNVGYFDLAIIDRHLIDFMRRIGAIGETNVKHLSKSRYISLESVLKSIALNLNISVGILDLFIWYKETNTIVK
What is the function of this protein?
Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA.  Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).
What are the official names of this protein?
8-oxoguanine DNA glycosylase/AP lyase.
What is the protein family that this protein belongs to?
Belongs to the type-2 OGG1 family.
Protein: K1C20_RAT
Sequence: MDFSRRSFHRSLSSSSQGPALSTSGSLYRKGTMQRLGLHSVYGGWRHGTRISVSKTTMSYGNHLSNGGDLFGGNEKLAMQNLNDRLASYLEKVRSLEQSNSKLEAQIKQWYETNAPSTIRDYSSYYAQIKELQDQIKDAQIENARCVLQIDNAKLAAEDFRLKFETERGMRITVEADLQGLSKVYDDLTLQKTDLEIQIEELNKDLALLKKEHQEEVEVLRRQLGNNVNVEVDAAPGLNLGEIMNEMRQKYEILAQKNLQEAKEQFERQTQTLEKQVTVNIEELRGTEVQVTELRRSYQTLEIELQSQLSMKESLERTLEETKARYASQLAAIQEMLSSLEAQLMQIRSDTERQNQEYNILLDIKTRLEQEIATYRRLLEGEDIKTTEYQLNTLEAKDIKKTRKIKTVVEEVVDGKVVSSEVKEIEENI
What is the function of this protein?
Plays a significant role in maintaining keratin filament organization in intestinal epithelia.  When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).
What are the official names of this protein?
Keratin, type I cytoskeletal 20, Cytokeratin-20, CK-20, Cytokeratin-21, CK-21, Keratin-20, K20.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: HEM0_PONAB
Sequence: MVTAAMLLQCCPVPARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGGDSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSASLKKPFSSPQEQEQISGKVTHLIQDNMPGNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLRATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFEAVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTEVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA
What is the function of this protein?
Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (By similarity).  Contributes significantly to heme formation during erythropoiesis (By similarity).
What are the official names of this protein?
5-aminolevulinate synthase, erythroid-specific, mitochondrial, ALAS-E, 5-aminolevulinic acid synthase 2, Delta-ALA synthase 2, Delta-aminolevulinate synthase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane.
Protein: CDD_SALPB
Sequence: MHPRFQTAFAQLADNLQSALAPILADHHFPAMLTAEQVSTLKNTAGLDEDALAFALLPLAAACARTDLSHFNVGAIARGVSGNWYFGANMEFLGATMQQTVHAEQSAISHAWLRGEKGLAAVTVNYTPCGHCRQFMNELNSGLDLRIHLPGRAPHTLRDYLPDAFGPKDLEIKTLLMDEQDHGFTLTGDTLTQAAITAANKSHMPYSHSPSGVALECKDGRIFTGSYAENAAFNPTLPPLQGALNLLSLNGYDYADIQRAILAEKGDAALIQWDATAATLKALGCHNIDRVLLG
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: RR12_CHLRE
Sequence: MPTIQQLIRSARKKITKKTKSPALKSCPQRRGICLRVYTVTPKKPNSALRKVARVRLTTGFEVTAYIPGVGHNLQEHAVVLVRGGRVKDLPGVRYHIVRGSLDTAGVKNRVQSRSKYGVKMGSKTAAKTAGKK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PISD_CAEEL
Sequence: MMPLFNVLRSARMLPAVSKKVVSPPMMLRSVRELTNQSKNVYATKEVIIGASQKKKRSWVKWLSVSTLIIGGASYVGYLFTPDWREIVDSKHYYSNWKIRVYLSLPFNTASRVIGGLANQEIPVWLREHLLGGFARMYDCRMDDCVDPDFKNYPSFAAFFNRKLKESTRPISASPLVSPADGTVLHFGKVEDNKIEYVKGHDYDVDKFLGDVDLPQKDELDLYQVVIYLAPGDYHAFHSPARWVANQCRHVPGLLLSVRPTLLSHVPHLFCLNERVVLNGSWRHGFFSMSAVAATNVGDIVVDAEPSLRTNIVRRKTQKIMNTETEIHAPYVSGERVGEFRLGSTIVLVFQAPPTIKFAIKAGDPLRYGQSLVADGV
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).  Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
[Phosphatidylserine decarboxylase beta chain]: Mitochondrion inner membrane; Single- pass membrane protein; Intermembrane side. SUBCELLULAR LOCATION: [Phosphatidylserine decarboxylase alpha chain]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.
Protein: DNAJ_STAS1
Sequence: MAKRDYYEVLGVSKSASKDEIKKAYRKLSKQYHPDINKEEGADEKFKEISEAYEVLSDENKRANYDQFGHDGPQGGFGGQGFGGQDFSGFGGGGFEDIFSSFFGGGRQQRDPNAPRKGDDLQYTMTVTFDEAVFGSEKEISIRKDVACHTCDGEGAKPGTKKKTCHYCNGSGHVSVEQNTILGRVRTEKVCPVCSGSGQEFEEPCPTCHGKGTENKNVKISVTIPEGVDNEQQIRLAGEGAPGENGGPQGDLYIVFRVKPSEKFERDGDDIYYSLDISIAQATLGDEVKVPTLKGSVMLTIPAGTQTEKQFRLKEKGIKNVHGYGYGDLFININVVTPTKISDRQKELLREFAEIDGEELSEQPSNFRDKAKRFFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 5H1AB_TAKRU
Sequence: MEGTNNTTGWTHFDSTSNRTSKSFDEEVKLSYQVVTSFLLGALILCSIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNRWTLGQIPCDIFISLDMLCCTSSILHLCVIALDRYWAITEPIDYMKKRTPRRAAVLISVTWLVGFSISIPPMLIMRSQPSSMAEDRANSKQCKITQDPWYTIYSTFGAFYIPLTLMLVLYGRIFKAARFRIRRTVRKTEKKKVSDTCLALSPAMFHRKTPGDAHGKSWKRSVEPRPLPNVNGAVKHAGEGESLDIIEVQSNSRCNLPLPNTPGTVPLFENRHEKATETKRKIALARERKTVKTLGIIMGTFILCWLPFFIVALVMPFCQESCFMPHWLKDVINWLGYSNSLLNPIIYAYFNKDFQSAFKKIIKCHFCRA
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various drugs and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores.  Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism.  Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity and behavior (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 1A-beta, 5-HT-1A-beta, 5-HT1A-beta, F1B, Serotonin receptor 1A-beta.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: APT_BLOFL
Sequence: MISHTDHQLTLIKENIKFIPNYPKQGILFRDITALLENPHAYSACIKLLADHYKNHQLTKIVGVEARGFLFGSPLALILKLGFIPARKAGRLPRNTISESYVLEYGTGCLEMHNDSIIPGDRVLIVDDLLATGGTIKAVVKLIRRLGGEVYHAAFVIDLEKLGGKLLLEKIGVHPYSLVIFSD
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAPA_DESDA
Sequence: MSTSRRDFLKYFAMSAAVAAASGAGFGSLALAADNRPEKWVKGVCRYCGTGCGVLVGVKDGKAVAIQGDPNNHNAGLLCLKGSLLIPVLNSKERVTQPLVRRHKGGKLEPVSWDEALDLMASRFRSSIDMYGPNSVAWYGSGQCLTEESYVANKIFKGGFGTNNVDGNPRLCMASAVGGYVTSFGKDEPMGTYADIDQATCFFIIGSNTSEAHPVLFRRIARRKQVEPGVKIIVADPRRTNTSRIADMHVAFRPGTDLAFMHSMAWVIINEELDNPRFWQRYVNFMDAEGKPSDFEGYKAFLENYRPEKVAEICRVPVEQIYGAARAFAESAATMSLWCMGINQRVQGVFANNLIHNLHLITGQICRPGATSFSLTGQPNACGGVRDGGALSHLLPAGRAIPNAKHRAEMEKLWGLPEGRIAPEPGYHTVALFEALGRGDVKCMIICETNPAHTLPNLNKVHKAMSHPESFIVCIEAFPDAVTLEYADLVLPPAFWCERDGVYGCGERRYSLTEKAVDPPGQCRPTVNTLVEFARRAGVDPQLVNFRNAEDVWNEWRMVSKGTTYDFWGMTRERLRKESGLIWPCPSEDHPGTSLRYVRGQDPCVPADHPDRFFFYGKPDGRAVIWMRPAKGAAEEPDAEYPLYLTSMRVIDHWHTATMTGKVPELQKANPIAFVEINEEDAARTGIKHGDSVIVETRRDAMELPARVSDVCRPGLIAVPFFDPKKLVNKLFLDATDPVSREPEYKICAARVRKA
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: Y1256_PROM4
Sequence: MELLIHQLLSKEESKKITSNITKDNSCWIDGKTSAGSYAAKVKNNLQLKKDSEVGVTNSNKVNNKLTSDQLIKSFALPRKVHGTMFTRSSVGQGYGMHVDNAYMSSGRSDLSFTIFLSSPNEYQGGELLIQSMQGVKEIKLNCGQIVIYPSTSLHSVKQVSQGERIVCVGWIQSYVANNEDRNFLFGLDAGARGLLAKHGRSDELDLVFQAYSNLLRRLGD
What are the official names of this protein?
PKHD-type hydroxylase P9211_12561.
Protein: CREB5_HUMAN
Sequence: MIYEESKMNLEQERPFVCSAPGCSQRFPTEDHLMIHRHKHEMTLKFPSIKTDNMLSDQTPTPTRFLKNCEEVGLFSELDCSLEHEFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSARLPNHDTNVVIQQAMPSPQSSSVITQAPSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPAHHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLNPIL
What is the function of this protein?
Binds to the cAMP response element and activates transcription.
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 5, CREB-5, cAMP-responsive element-binding protein 5, cAMP-response element-binding protein A, CRE-BPa.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GATB_RHIE6
Sequence: MTLVDVRTPDPKRFIPGATGDWEVIVGMEVHAQVLSNSKLFSGASTEFGKPQNSNVSLVDAAMPGMLPVINEECVKQAVRTGLGLKAQINKRSLFDRKNYFYPDLPQGYQISQFKDPIVGEGKIVISLGPDRQGQFEDIEIGIERLHLEQDAGKSMHDQHATMSYVDLNRSGVALMEIVSKPDMRSSDEAKAYMTKLRSIVRYLGTCDGNMDEGSMRADVNVSVRRPGEAFGTRCEIKNVNSIRFIGQAIEYEARRQIGILEDGGTIEQETRLFDPNKGETRSMRSKEDAHDYRYFPDPDLLPLEFDDAFVTALAADLPELPDDKKERFVRELGLSVYDASVLVSEKAIADYFEAVAAGRDGKTAANWVINDLLGALNRTGKDIEQTPVSPAQLGAIIDLIKAGTISGKIAKDLFEIVLTEGGDPAEIVESRGMKQVTDTGAIEKAVDEIIAANPDQVEKVKAKPTMAAWFVGQVMKATGGKANPQAVQALVKAKLGIEE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: ILIB_HYPJQ
Sequence: MTVIDVLPQTQRALKIVGPNAVSVNAAAPLPDIEPTDVLVRVVCVSINPVDGKAADMSPQLGATSGTDFSGVVVALGADVEADNWREANTMKPVRIGDRVFGGIFGNDPLRPHNGAFADYVAVPARLVWHIPTGTDFATAATMGAAIATVGLSLFNYLGLPLPSKSKAGLPVVTTCSAASSTNVLQLGAEAWFDYKSPTCGADIREHTNDSLAFALDCITDTASMGICYEALGSAGGRYVALDAFPVRGHTRRSVVPEWVCTPTQFGKAIRWTPPYDLEPRPYDLKCAELWYVVAQRLIDEGLIASHPLEKRNGGLSAVPEGMEEVRRGQIKGKKLVYTILDSEPIAVSA
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:34947016).  IliB collaborates with the hybrid PKS-NRPS synthetase iliA to assemble the backbone of ilicicolin H (PubMed:34947016).  The PKS portion of iliA and trans-acting enoyl reductase iliB work together to construct an octaketide, and two methyl groups are introduced by the MT domain of iliA during the chain assembly (PubMed:34947016).  The nascent chain is then condensed with tyrosine, catalyzed by the iliA C domain, and the resulting PKS-NRPS hybrid is offloaded by the iliA RED domain to form an advanced tetramic acid intermediate (PubMed:34947016).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (PubMed:34947016) (Probable).
What are the official names of this protein?
Trans-enoyl reductase iliB, Ilicicolin H biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: MURG_COXBU
Sequence: MNRILIIAGGTGGHIFPALAVARELREQEVDVQWLGVKGGLEEKLVPDSFPLHLIQIKAFRGKRGLQQLLMPLRLVRAVFQAYRIIRQFKPDVILGMGGYVAGPGGLAAWITRTPLIIHEQNSIPGLTNRVLAKMAKFILQGFPDTFPQNRKVITTGNPVRTELVKMPLPQVRLAARRGPLRILVLGGSQGARSINQKMLAALSSYPRSEEIAVWHQTGQRDFEFIQKEYEKIKIEAKVDNFISDMAGAYGWADLVVCRAGALTVCEIASVGVASIFIPYPHAVDNHQFHNARFLEQAGAAIIISEESLTETDLMRWFEQFAQDRDRLLTMAENARKLAKPEAVQRVIAQCKKFYAAR
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CIRE_CHAPA
Sequence: KIPCGESCVWIPCLTSVFNCKCENKVCYHD
What is the function of this protein?
Probably participates in a plant defense mechanism.  Inhibits the cytopathic effects of the human immunodeficiency virus.
What are the official names of this protein?
Circulin-E, CIRE.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: ISAA_STAA1
Sequence: MKKTIMASSLAVALGVTGYAAGTGHQAHAAEVNVDQAHLVDLAHNHQDQLNAAPIKDGAYDIHFVKDGFQYNFTSNGTTWSWSYEAANGQTAGFSNVAGADYTTSYNQGSDVQSVSYNAQSSNSNVEAVSAPTYHNYSTSTTSSSVRLSNGNTAGATGSSAAQIMAQRTGVSASTWAAIIARESNGQVNAYNPSGASGLFQTMPGWGPTNTVDQQINAAVKAYKAQGLGAWGF
What is the function of this protein?
Is able to cleave peptidoglycan.
What are the official names of this protein?
Probable transglycosylase IsaA, Immunodominant staphylococcal antigen A.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase family. IsaA subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: BCL2_HUMAN
Sequence: MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
What is the function of this protein?
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370).  Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354).  Appears to function in a feedback loop system with caspases (PubMed:11368354).  Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354).  Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:21358617, PubMed:20889974).  May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
What are the official names of this protein?
Apoptosis regulator Bcl-2.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm.
Protein: RL33_MARMM
Sequence: MAKPTTIKIRLNSTAGTGYFYVTKKNARTMTEKLVLKKYDPVARKHVDFKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: ZNHI3_MOUSE
Sequence: MASLNCRTAVCVVCLEKPKYRCPTCRVPYCSVPCFQKHKEQCSSEARPVEKRRAGPPVRSEESKDDDSSVADFLNSDEEEDRVSLQNLKNLGESETLRSLLLNPHLRQLMISLDQGDNKAKLMRACMQEPLFVEFADCCLGIVEPSQKRDS
What are the official names of this protein?
Zinc finger HIT domain-containing protein 3, Thyroid hormone receptor interactor 3, Thyroid receptor-interacting protein 3, TR-interacting protein 3, TRIP-3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MTCU_CALSI
Sequence: MPCGCGTSCKCGSGKCCCGSTCNCTTCPSKQSCSCNDGACGSACQCKTSCCCGADCKCSPCPMK
What is the function of this protein?
The metallothioneins are involved in the cellular sequestration of toxic metal ions and regulation of essential trace elements.  This isoform binds exclusively copper.
What are the official names of this protein?
Copper-specific metallothionein-2, CuMT-II.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 2 family.
Protein: NAPES_ARATH
Sequence: MGKIMEWAARSDHLGGIPRNTVIMAVSAFAKAVANLCNKSSVHNADTLMNLVQSRPPGVPLITVSNHMSTLDDPVMWGAFKGLLSLDPELARWVLAAEDICFRNPIFSYIFRTGKCIPITRGGGIYQENMNEALQRLKDGSWLHTFPEGKVFQDDVPIRRLKWGTASLIARSPVTPIVLPIIHRGFEEMMPENYNNGRRPLVPLPNKHLKVVVGEPIEFDVPMMVETAVLDSRHVTPPLQEVKWPVLTSAGQVLDETAQRHLYIALSEKIQSSLETLRLLAKRL
What is the function of this protein?
Acyltransferase that catalyzes the N-acylation of phosphatidylethanolamine to form N-acylphosphatidylethanolamine (N-acyl-PE) (e. g.  NAPEs containing C16:0, C16:1, C18:0, and C18:1).  Mediates also the formation of acylphosphatidylglycerol (acyl-PG) from lysoglycerophospholipid by O-acylation.  Uses acyl-CoA as acyl donors.  Acylates 1-acyllysophosphatidylethanolamine (1-acyllyso-PE) and 1-acyllysophosphatidylglycerol (1-acyllyso-PG) at the sn-2-position.
What are the official names of this protein?
N-acylphosphatidylethanolamine synthase, NAPE synthase, Lysoglycerophospholipid acyltransferase, Monolysocardiolipin acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the taffazin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: NEMA3_LINLC
Sequence: GCIKTGSGCTLSKGCCTKNCGWNFKCNPPNQ
What is the function of this protein?
Toxin with similar potency against both insect and mammalian sodium channels (Nav) (PubMed:34445875).  It inhibits inactivation of most Nav tested (B. germanica (BgNav1); EC(50)=97. 5 nM, hNav1. 1/SCN1A; EC(50)=125. 8 nM, rNav1. 2/SCN2A; EC(50)=137. 8 nM, rNav1. 3/SCN3A; EC(50)=138. 9 nM, rNav1. 4/SCN4A; EC(50)=150. 2 nM, hNav1. 5/SCN5A; EC(50)=108. 4 nM, mNav1. 6/SCN8A; EC(50)=92. 8 nM, hNav1. 9/SCN9A; EC(50)=102. 2 nM) (PubMed:34445875).  1 uM is enough to completely inhibits the inactivation, resulting in sustained non-inactivating currents (By similarity).  In addition, the toxin significantly enhances the recovery from inactivation, and the open state is not required for the toxin to interact with the channel (By similarity).  In vivo, injection into brine shrimp (Artemia salina) stops movement or causes death after 24 hours (EC(50)=4. 7 uM) (PubMed:34445875).
What are the official names of this protein?
Nemertide alpha-3.
What is the protein family that this protein belongs to?
Belongs to the nemertide family.
What are the subcellular locations of this protein?
Secreted.