PharMolix/UniProtQA huggingface dataset:
Protein: GLMM_PARP8
Sequence: MARRYFGTDGIRGKVGDPPITPDFVLRLGYAAGKVLAGADTWAKTGSRPTVLIGKDTRVSGYMLEAALESGFSAAGVDVMLAGPMPTPGVAYLTRALRLAAGVVISASHNPYYDNGIKFFSADGNKLPDEVESQIEEQLDKPLECAPSERLGKARRLDDAAGRYIEFCKGTFPQAFDLRGMKLVVDCAHGAAYDVAPHVFHELGADVITIGVSPNGFNINDGVGATAPDALVRAVRANKADLGVALDGDADRLQIVDANGRLYNGDELLYVLVQDRIATQGKVDGAVGTLMTNMAVEVALKNKGVQFVRAAVGDRYVLEKLREHGWELGAEGSGHILSLDRHSTGDGIVSALLVLAAMQRSGRSLEQLLEGVTLFPQKLINVRMQPGADWKGNDAIRRAINEAEGALDGSGRVLIRASGTEPVLRVMVEAAHEKDAVHHAERIATVVKQATS
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RL32_CHLTR
Sequence: MAVPRNRHSNARKNIRRSHHAKKACSAAVCSNCKQAFIPHTVCASCGFYKGKAVITVEK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: PSBM_CHLRE
Sequence: MEVNIYGLTATALFIIIPTSFLLILYVKTASTQD
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MURI_CARST
Sequence: MKKQAIGFIDSGVGGLTVVKEAMRQLPNESIYYVGDTARCPYGPRPEDQVRKFTWEMTHFLLDKNIKMLVIACNTATAAALKDIKKKLAIPVIGVILPGSRAAIKATHTNRIGVIGTEGTVKSNQYKKMIHSKDTKALVTSLACPKFVPLVESNEYSSAIAKKVVAETLRPLKNEGLDTLILGCTHYPLLRPIIQNTLGDSVTLIDSGAETVSEVSTILDYFNLAVDSQNKEKAERNFYTTGSSQMFHAIASEWLQLDDLAVEHITLG
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: BCA1_CAEEL
Sequence: MNKILRGVIQFRNTIRKDLVKQFEEIKNNPSPTAVMFTCMDSRMLPTRFTQSQVGDMFVVRNAGNMIPDAPNYGAFSEVSVNTEPAALELAVKRGGIRHIVVCGHSDCKAINTLYGLHQCPKNFDVTSPMDHWVRRNGFASVKRLNERLHRGPSSMKFESEVAPSQSFDAIIDPMDTLAMEDKLSQINVLQQLINICSHEFLKEYLESGRLHIHGMWFDIYKGEDYLFSKDKKRFVVIDEKTVTDLLAELNARYPVPEDQDGPVAFAKSN
What is the function of this protein?
Reversible hydration of carbon dioxide.
What are the official names of this protein?
Beta carbonic anhydrase 1.
What is the protein family that this protein belongs to?
Belongs to the beta-class carbonic anhydrase family.
Protein: RL28_BORBU
Sequence: MARKCEITGKKTMFGNNVPRKGLAKKKGGAGQHIGVKTKRTFKVNLINKKFFIPNLGRSVSIKVSANALRSISKIGLDAFLKKNCKKIENFL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: SCX2_TITST
Sequence: KEGYAMDHEGCKFSCFIRPAGFCDGYCKTHLKASSGYCAWPACYCYGVPDHIKVWDYATNKC
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission (By similarity).  Is toxic to mice (PubMed:8611151).
What are the official names of this protein?
Toxin Tst2, P-Mice-beta* NaTx5.2, Tityustoxin II, TsTX-II, Toxin III-8.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGR_HELMI
Sequence: MKSRRQRAILEIIGAEVVRTQEELAQRLRERGMEVTQATVSRDIKELGLIKVPVSKDESRYAPPAEAAQVPQAQDRLRRLLRDTVTHVDSSLNIVVIRTLPGHAHAVAGAIDHSHWPEVLGTVAGDDTIFIVVKPVEAVEALMDKVRRWVE
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KV05_RABIT
Sequence: DVVMTQTPASVSEPVGGTVTIKCQASQSIYSGLAWYQZKPGQPPKLLIYKASTLASGVSSRFKGSGSGTEFTLTISDLECADAATYFCZGSTYGGGYFGGGTEVVVKG
What are the official names of this protein?
Ig kappa chain V region BS-1.
Protein: SPL2A_BOVIN
Sequence: MVQLWKLVLLCGLLAGTSESLLDIRGNDVLRRLISGLERGLGTFDSTIEIIFQNLKTELESRCLNDVVEETQQTENSLEGLISRIFQVVNRLTGVRIRNVQVPDITFEATSENSADVSIPITADVTVSLPLLGEIVKLDLNVDLQTSVSIETDAETGDSRVVVGECPNNPESISLTVLHRRPGLLNDVVDFGVNLVRQLVSSVVQHELCPRIRELLESLDTECIKKLIGEPQVTTQQEI
What are the official names of this protein?
Short palate, lung and nasal epithelium carcinoma-associated protein 2A, BSP30a, Common salivary protein form a.
What is the protein family that this protein belongs to?
Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
What are the subcellular locations of this protein?
Secreted.
Protein: GUF1_YARLI
Sequence: MWKGLLQSTRAAWRGPCVRAPRLPFFRRYSLCVDPEIAALSGPELEARIAAIPIERYRNFSIVAHVDHGKSTLSDRLLELTGVIAAGGQKQFLDKLDVERERGITVKAQTCTMLYKHKGEDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDASQGVQAQTVANFFLAFSLNLTLLPVINKIDLEVADIPRSMDQIESTFELPTDNVLQVSAKTGLNVDQILPNVIENIPGPDGKLEDPLRALIVDSWYDNYLGVVLLTYVRDGVVSRGTKVISHHTGRKYDVKEVGIMYPGSVKTKELKAGQVGYMALGMKSSSEAHTGDTLIKVNSNAEPLPGFAETKPMVFVGVFPGEGMDFADLEESLQHLTLNDRSVTMTKATSQALGQGWRMGFLGTLHASVFEDRLLQEHGAHVIITAPSVPYRVVYHPRGKETEPTIVEIDNPANFPDLQLEKARIQSLEEPMVACTMTLPQEYIGSVMSLCEANRGEQVDMNYLNQTQVLLKYRIPLNQLVEDFFGKLKAASQGFASLDYEEDGYMASKLVRLDMCVNGEVVDALSQVMHVSQAETRARDWVEKFKTFLRWHQFDVIIQAKIGNKILARETIKARKKDVLAKLHAADLSRKAKLLKNQKAGKNRLQTAGRVNIPKEAFSGFLSKT
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: NEK10_MOUSE
Sequence: MPDQDTKAKSTEKTADKQQGTTTRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNNMTKSEPTIRTGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQHQLFQEIFTALVRNRLICREWVNRAPSIHFLRVLICLRLLMRDPCYQEILHKLGGIEDLAQYMEIVANEYLGYAEEQHCVDKLVNMTYIFQKLAAVKDQREWVTASGAHKTLVSLLGARDTTVLLGALLALASLAESSECREKISELNVVENLLMILHEYDLLSKRLTAELLRLLCAEPQIKEQVKLYEGIPILLSLLHSDHLKLLWSVIWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDRSSIGSLSSANAAGRIQQLHLSEDLSPGEIEENTVSLQAACCAALTELALNDTNAHQVVQENGVYTIAKLILPNKQSNAAQTNLLQCYAFRTLRFLFSMERNRPLFKRLFPTDLFETFIDIGHYVRDIGAYKDLVSQLNLLLEDELKQIAENIESINQKKAPLKYIGDYAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIKEQLYHPNVVRYYKTFLENDRLYIVMELIEGAPLGEHFNSLKEKHHHFSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQESSKLTSMVGTILYSCPEVLKSEPYGEKADVWAAGCILYQMATLSPPFCSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTIRRCLTPDAEARPDIVEVSSMISDVMMKYLDRLSTSQLALERKLERERRRTQRYFMEANRNAVTCHHELALLSQETFEKASLSSSSSGAASLKSELSESAELPGEGCHIPCGKEEDRVCEEVLSEDNFQLESVEKDLYSELDDELDVSDNCSSSSSSPLKESTFSILKRSFSASGRERHSQARDFIAGLGSRPRPGPQMSTFVVESASAGIAVSQRKVRQICDPIQQILIQLHKVIYITQLPPALHHDLKRRVIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIELNFLTSDYHSLRHSRAANNWSPSDPTGSPSSFEVEEGVTYEQMQTVIEEVLEESGYYNFTTKR
What is the function of this protein?
Plays a role in the cellular response to UV irradiation.  Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation.  In ciliated cells, it is involved in the regulation of mucociliary transport.
What are the official names of this protein?
Serine/threonine-protein kinase Nek10, Never in mitosis A-related kinase 10, NimA-related protein kinase 10.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Protein: ASNA_STRPN
Sequence: MKKSFIHQQEEISFVKNTFTQYLKDKLEVVEVQGPILSKVGDGMQDNLSGVENPVSVKVLQIPDATYEVVHSLAKWKRHTLARFGFGEGEGLFVHMKALRPDEDSLDATHSVYVDQWDWEKVIPNGKRNIVYLKETVEKIYKAIRLTELAVEARYDIESILPKQITFIHTEELVERYPDLTPKERENAICKEFGAVFLIGIGGELPDGKPHDGRAPDYDDWTSESENGYKGLNGDILVWNESLGGAFELSSMGIRVDEETLRRQVEITGDEDRLELEWHKSLLNGLFPLTIGGGIGQSRMAMFLLRKRHIGEVQTSVWPQEVRDTYENIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2HA_BOTAS
Sequence: MRTLWIVTVLLVGVEGSLVELGKMILQETGKNPLTSYGVYGCNCGVGGRHKPKDGTDRCCYVHKCCYKKMTDCDPKKDRYSYSWKDKTIVCDENNPCLKELCECDKAVAICLRENLDTYNKKYKIYPKFFCKKAEPC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks enzymatic activity (By similarity).  Is myotoxic and displays edema-inducing activities (By similarity).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog 4a, svPLA2 homolog, Myotoxin IVa, MT-IVa.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FTHS2_STRSV
Sequence: MKTDIEIAQSVELQPIVDVVKKVGIDYDDLELYGKYKAKLSFDKIREVEKNPVGKLILVTAINPTPAGEGKSTITIGLADALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGHAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNALGIDQRRIIWKRVVDLNDRALRHVTVGLGSPVNGIPREDGFDITVASEIMAILCLATDIEDLKKRLANIVIGYRYDRTPVYVRDLEVEGALALVLKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLDIKTPNLPTSPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEVATLKELCAEIGVPVELASVWADGAEGGVTLAETVVKTIAEEPAHYTRLYDNDLSIEEKIEKIVTEIYRGSKVNFEKKAQTQIREIVKNSWDKLPICMAKTQYSFSDNPASLGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVAADGTAIGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase 2, Formyltetrahydrofolate synthetase 2, FHS 2, FTHFS 2.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: OTULL_HUMAN
Sequence: MAATRSPTRARERERSGAPAAGSDQVHSWMLATSQALDTVWRMAKGFVMLAVSFLVAAICYFRRLHLYSGHKLKWWIGYLQRKFKRNLSVEAEVDLLSYCAREWKGETPRNKLMRKAYEELFWRHHIKCVRQVRRDNYDALRSVLFQIFSQGISFPSWMKEKDIVKLPEKLLFSQGCNWIQQYSFGPEKYTGSNVFGKLRKYVELLKTQWTEFNGIRDYHKRGSMCNTLFSDAILEYKLYEALKFIMLYQVTEVYEQMKTKKVIPSLFRLLFSRETSSDPLSFMMNHLNSVGDTCGLEQIDMFILGYSLEVKIKVFRLFKFNSRDFEVCYPEEPLRDWPEISLLTENDRHYHIPVF
What is the function of this protein?
Lacks deubiquitinase activity.
What are the official names of this protein?
Inactive ubiquitin thioesterase OTULINL.
What is the protein family that this protein belongs to?
Belongs to the peptidase C65 family. Otulin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope.
Protein: PA22_OXYSC
Sequence: MHPAHLLVLLAVCVSLLGASDIPPLPLNLAQFGFMIRCANGGSRSPLDYTDYGCYCGKGGRGTPVDDLDRCCQVHDECYGEAEKRLGCSPFVTLYSWKCYGKAPSCNTKTDCQRFVCNCDAKAAECFARSPYQKKNWNINTKARCK
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows high presynaptic neurotoxicity in vertebrata that is independent of catalytic activity (PubMed:2544597, PubMed:10548416, PubMed:16669624), as well as local myotoxicity when intramuscularly injected into mice (PubMed:16669624).  Blocks acetylcholine release in Aplysia neurons (PubMed:8583413), and potentiates pro-inflammatory cellular signaling (PubMed:12782627).  Potentiates glutamate excitoxicity when coinjected into brain of rats (PubMed:10548416).  May act by binding in a calcium-dependent fashion and with high affinity to a neuronal-type (N-type) PLA2 receptor, and with very high affinity to a muscle-type (M-type) PLA2 receptor.  In vitro, shows a high-specific activity on E. coli membranes and is more efficient on the anionic phospholipid POPG than on the anionic phospholipid POPS or the zwitterionic phospholipid POPC.  Exerts catalytically-independent anti-HIV (IC(50) is 35 nM) activity and catalytically-dependent antimalarial activity (IC(50) is 3. 1 nM when tested on P. falciparum grown in serum that contains lipoproteins).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2 OS2, PLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: QACC_STAAU
Sequence: MPYIYLIIAISTEVIGSAFLKSSEGFSKFIPSLGTIISFGICFYFLSKTMQHLPLNITYATWAGLGLVLTTVVSIIIFKEQINLITIVSIVLIIVGVVSLNIFGTSH
What is the function of this protein?
Multidrug exporter.  Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide.
What are the official names of this protein?
Quaternary ammonium compound-resistance protein QacC, Ethidium bromide resistance protein, Multidrug resistance protein, Quaternary ammonium determinant C.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KUP_XANC8
Sequence: MSHTPTPAAGSGHAPANGHMALVIGAIGVVFGDIGTSPLYTLKEAFSPHYGLTSDHDTVLGVLSLAFWALMITVTLKYVTIIMRADNEGEGGIMALMALTQRTLKQGSRSAYVVGILGIFGASLFFGDGVITPAISVMGAVEGLEIAAPSLHPFIVPITVVVLLVVFMVQRFGTEKVGKVFGPITCLWFLSLGAIGIWNIVDAPEVLKAFNPWWAIRFFMEHGWHGVFILGAVVLAVTGGEALYADMGHFGARPIRHGWYFFVLPMLLLNYLGQGALVLNHPAALKNPFFEAVPSWALYPMIILATLAAVIASQAVITGAYSVARQAMQLGYIPRMLIKHTSRDTIGQIYVPGINWLLMVMVIALVLIFRSSTNLAVAYGISVSMTMLIDTLLLALVARSLWPRWRNWVLPLCVVFFIIELAFVIANGAKLLQGAWFPLALGIVVFTLMRTWRRGRALLREEIRKDGIRIDSFLPGLMLAPPARVPGMAVFLTADPMVVPHALMHNLKHNKVLHERNIFLNVDTLPIPYAPADKRLQIESIGDEFYRVYVRFGFMETPDVPLALMRSCDQGGIHFDPMDTTFFASRETIVASANRGMPIWRDKLFALMHRNAAPATGFFRIPGNRLVELGAQVEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CUTC_PROMH
Sequence: MAKLEICCFGAECALIAERSGADRIELCTSPSEGGVTPSYGILKQVIDLVRIPVHPIIRPRGGDFCYSQADFAAMKNDISMIRDMGFSGAVVGILNEEGHIDLPKMAILMELAGPLAITFHRAFDMCINPLLALDQLTQLGVARILTSGQQANAELGLPLLRTLNEKTQGPIIMAGAGVRLSNIQKFLDSGLQEIHSSAGKQAPSTMNYRKAGVTMSSDSEVDEFTHYCVDEDVVGAMKDIMSIYTTSVN
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHRS6_DANRE
Sequence: MGRLDGKVIVLSAAAQGIGKASAIAFAKEGAQVTATDINGEKLKELDGIPGIKTKVVDVTKKDQVDALAKDFDHVDVLFNIAGFVHHGSILDCEESDWDFTMNVNVRSMYLMIKAFLPKMLARKSGNIINMASVASSIKGVVNRCVYSTSKAAVIGLTKSVAADFLEQGIRCNCICPGTVDTPSLRERIQARPDPEQAFKDFMARQRTGRLCTAEEVAHLCVYLASDESTFVTGTEVIIDGGWRL
What is the function of this protein?
NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity).  Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (By similarity).  Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress.  The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity).  May act as a 3-hydroxybutyrate dehydrogenase (By similarity).
What are the official names of this protein?
Dehydrogenase/reductase SDR family member 6, (R)-beta-hydroxybutyrate dehydrogenase, 3-hydroxybutyrate dehydrogenase type 2, 4-oxo-L-proline reductase, Oxidoreductase UCPA, Short chain dehydrogenase/reductase family 15C member 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: ILVC_XANOR
Sequence: MSNDTQPKIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTESKAQADGFTVVAPSEAVKSADLVAILTPDMVQKKLYEDVIAPNMKQGACLLFAHGLNVHFDMITPRADLDVVLVAPKGPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGGLGGARANIIKTTFKEETETDLFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFVSETAQYGDYVSGPRVIDASTKARMKDVLTDIQNGTFTKNWVAEYEAGLPNYTKFKQADLEHPIEEVGKKLRAKMVWLNGEQQAAAAPANQQAA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: CYAY_RICCN
Sequence: MNNSEFSKIAETTIAYIAEKIEEQDKEASIDVDLQGDILNLDTDKGVYVINKQSAAKEIWLSSPVSGPYHFFYEQGEWTNRAGLELMAILTEELNIKFDTRPT
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: SNF6_YEAST
Sequence: MGVIKKKRSHHGKASRQQYYSGVQVGGVGSMGAINNNIPSLTSFAEENNYQYGYSGSSAGMNGRSLTYAQQQLNKQRQDFERVRLRPEQLSNIIHDESDTISFRSNLLKNFISSNDAFNMLSLTTVPCDRIEKSRLFSEKTIRYLMQKQHEMKTQAAELQEKPLTPLKYTKLIAAAEDGSRSTKDMIDAVFEQDSHLRYQPDGVVVHRDDPALVGKLRGDLREAPADYWTHAYRDVLAQYHEAKERIRQKEVTAGEAQDEASLQQQQQQDLQQQQQVVTTVASQSPHATATEKEPVPAVVDDPLENMFGDYSNEPFNTNFDDEFGDLDAVFF
What is the function of this protein?
Involved in transcriptional activation.  Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes.  It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
What are the official names of this protein?
Transcription regulatory protein SNF6, SWI/SNF complex component SNF6.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL24_FRAAA
Sequence: MTVATLKIKKGDTVQIITGKDRGLKGKVIRAYPEQNKVLVEGANRITRHTRVQQSARGSQSGGIVTQEAPIHVSNVMIVDPSDGRPTRIGYRINEDGTKVRISRRTGAEL
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: STN1_YEAST
Sequence: MDKYGHIAHQEGDVCYYIPRLFKYNSYYSGTEDVRIFVGDLKYRMRVSLQICEKYYDRRLSMLFWKNHPLQQIHLIGCIIGLQFKWIGKQEYIFFQLDDCTSDSSLVGYTSDMRFLTCKVKKDSILSWGLNITDLIGLTLHVYGQASLNYQELQVEYLRLCYSLTEEIDHWKITMNMREQLDTPWSLSDFVIGELFTQEQEWTPETSQIEVVNPDFVGIGYKTPESKRNETTFIEQLQEERLKDELEIISPYNSTDTSNSVHSLSFRFVSSLKDFPETHFLNSGDQIDNGNDEQLKKLEYQSANLPVMIPNRTSAKSNLMLILLGLQMKEISNSDLYKLKEVRSVVTSLASFLFQQQNVGVMKSFDSLEKEAFRDLVNRLVSQGLIGLKDKTSETFDLLPLKNLFEYAEKRISVLMKLQCYTGTVQLSHVQEKLHLPYITTNGIVDVFKECLKRTKKQYPEVLKNWWIDLDPKNGMEDQNSGILLHLEYAAAYS
What is the function of this protein?
Has a role in telomere length regulation and telomere end protection.  Acts as an inhibitor of telomerase loading through its interaction with CDC13.
What are the official names of this protein?
Protein STN1.
What are the subcellular locations of this protein?
Chromosome, telomere.
Protein: AGAL_ECOLI
Sequence: MMSAPKITFIGAGSTIFVKNILGDVFHREALKTAHIALMDIDPTRLEESHIVVRKLMDSAGASGKITCHTQQKEALEDADFVVVAFQIGGYEPCTVTDFEVCKRHGLEQTIADTLGPGGIMRALRTIPHLWQICEDMTEVCPDATMLNYVNPMAMNTWAMYARYPHIKQVGLCHSVQGTAEELARDLNIDPATLRYRCAGINHMAFYLELERKTADGSYVNLYPELLAAYEAGQAPKPNIHGNTRCQNIVRYEMFKKLGYFVTESSEHFAEYTPWFIKPGREDLIERYKVPLDEYPKRCVEQLANWHKELEEYKKASRIDIKPSREYASTIMNAIWTGEPSVIYGNVRNDGLIDNLPQGCCVEVACLVDANGIQPTKVGTLPSHLAALMQTNINVQTLLTEAILTENRDRVYHAAMMDPHTAAVLGIDEIYALVDDLIAAHGDWLPGWLHR
What are the official names of this protein?
Alpha-galactosidase, Melibiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 4 family.
Protein: TGT_CHLMU
Sequence: MALRFEILHQSKKSRARVGRIETEHGCIDTPAFVPVATNGALKGVLDHSNIPLMFCNTYHLIVHPGAEAVAAMGGLHQFIGRNAPIITDSGGFQIFSLAYGSVAEEIKSCGKKKGENSIIKINDEGVWFKSYRDGRKLFLSPEVSVQAQKHLGADIIIPLDELLPFHTDPAYFQQSSQRTYAWEKRSLDYHLANPGYQSMYGVIHGGTFPDQRKLGCQFVEDLPFDGSAIGGSLGKNLRDIVGVVDVTTANLSIERPRHLLGIGDLPSIWATVGFGIDSFDSSYPTKAARHGMILTSQGSLKINNQRYASDLNPIEPGCACPACSQGISRAYLRHLFKVHEPNAGIWASIHNMHYMQKIMSKIREKILNDQL
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.