PharMolix/UniProtQA huggingface dataset:
Protein: CAS1_THEKO
Sequence: MRKRSLTLFSDGNLFRRENTLYFENAQGRKPLAVEGIYDIYVYGHVNISSQALHFLAQKGIPVHFFNHYGHYDGSFYPRESLLSGDLIIKQAKHYLDQEKRLILAKLFVRGSALNMEKNLKRWKVADGFSGLLDELFEELESARKITEVMNVEARIRGEYYTRWDNALPEGFKIVKRTRRPPENEMNALISFLNSRLYATIVSELYNTQLAPTVSYLHEPGERRFSLALDLSEIFKPIIADRIANRLVKQGIIKREHFRGELNGVLLTKEGMKVVLKAYNEELGRSVKHPGLKKNVTKQRLIRLEAYKLIKHLVGVKDYEPLVAWF
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Acts as a dsDNA endonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endonuclease Cas1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endonuclease Cas1 family.
Protein: CMOA_ECOL5
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCKIIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHKAGFEHSELWFQCFNFGSLVALKAEDAA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: Y4GJ_SINFN
Sequence: MGASASTGLSRSQAALRIAPCQRWQIHPALRRPIFRACGRICRPRRKTQIAQTIATLMRRMQAIPGTPGRGLGRADQLEQKKVLAAFGGHAAKNKSNAYMLKGSEAETDAKARGDWEAAMEAFGQSQDEFHETSPRAKNASFTWTAVDGEFAAPSERITNEMLAEITERNADFLGHAQSGLEMLRRFEKRAG
What are the official names of this protein?
Uncharacterized protein y4gJ.
Protein: RL27_PEA
Sequence: MVKFLKPNKAVILLQGRYAGKKAVIVKTFDDGTREKPYGHCLVAGIKKFPSKVIKKDSAKKTAKKSRVKAFVKLVNYQHLMPTRYTLDVDLKDAVVPDVLQSKDKKVTALKETKKSLEERFKTGKNRWFFTKLRF
What are the official names of this protein?
60S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL27 family.
Protein: IF3_XYLFT
Sequence: MGDCNISTSDNKQNRKNHEIRVPRVRVIGSDGEMIGVLSRDEALAMAEKEGLDLVEIQPQADPPVCKVMNFGKFKFEQQKKANEAKKKTKQVEIKELKFRPVTDEGDYQIKLRNMRRFLEEGDKVKINIRFRGREMSHQELGRQMAARIEMDLGDDVVIESRPRLEGRQMVMMVAPRKKS
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_PSEAE
Sequence: MQAATETIVAIATAQGRGGVGIVRVSGPLAGQMAVAVSGRQLKARHAHYGPFLDAGGQVIDEGLSLYFPGPNSFTGEDVLELQGHGGPVVLDLLVQRCLELGARQARPGEFSERAFLNDKLDLAQAEAIADLIEASSEQAARNALRSLQGEFSRRVHALTEQLISLRIYVEAAIDFPEEEIDFLADGHVLGLLEKVRTELSTVQREASQGALLRDGMTVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHVVDTAGLRDTEDHVEKIGVERALKAIGEADRVLLVVDATAPEAADPFSLWPEFLDQRPEPGKVTLIRNKADLSTESIGLEESADGHVTITLSARTGAGLELLREHLKACMGFEQTAESGFSARRRHLEALRLAGQALEHGHSQLIHNGAGELLAEDLRQAQQHLGEITGAFTPDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAPC_EMENI
Sequence: MQPALAPAPHPSMQTSAQDHADQVLHDSLLAAQHLSQHPQQPRPQQPNAQPHHLQPTATTSPRDQNNIDPAISGGAMLPPSQPPAQPEPTVEDETPKTYGKRPLSTSKRAAQNRAAQRAFRQRKESYIRKLEEQVKEYEVMSQEYKALQAENYQLREYVINLQSRLLDSQGEVPELPGNIDLNQPRTEISVPQPAPRPGQAGASAPPQGSPQSQVSIANDDMNSLNRIAEAGLGMRKHPNEEAFLSNNFQARRGRGDETADPSETKTEPPTHGLPMVS
What is the function of this protein?
Putative transcription factor.
What are the official names of this protein?
Putative transcription factor kapC.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: H2B5_CHICK
Sequence: MPEPAKSAPAPKKGSKKAVTKTQKKGDKKRRKSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B 5, H2B V.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: HCP_MOOTA
Sequence: MFCYQCEQTAGGSGCTRVGVCGKNEDIASLQDTIIIGLKGIAAYAYHAGELGARDPEVDAFMHEALFTTLTNVDFDLNRHIETALKVGAMNLRVMELLDRAHVERFGAPEPTKVSTGTKAGPGILVTGHDLLDLYELLRQTEGTGINVYTHGEMLPAHAYPELKKFPHLVGNYGSAWQNQKKEFEDFPGAILGTTNCVLIPKESYRERMFTCGIAGLPGVTHIKNRDFTPVIEKAKSLPPLEEKAGGELTTGFHHQAVLKLAGQIIDAVKAGKIRHFFLVGGCDGAKPGRNYYTEFVEKVPKDCVVLTLGCGKYRFNHLDLGDIDGIPRLLDMGQCNNAYSALQVALALADAFKCSVNELPLSLVLSWFEQKAVAILLTLLHLGVRNIRIGPSLPAFLTPGVLKVLQEKYNLKPITTPEQDLKEILG
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_SALTO
Sequence: MESFGARLHRVVGERGPLCVGIDPHPGLLERWGLDDDVRGLERFAGTVVEALGDRVAVVKPQSAFFERFGSRGVAVLESTIRQLRTAGSLVLLDVKRGDIGSTVAAYASAYLDPSSPLHVDAVTVSPYLGVGALAPMFELAAAQGGGVFVLALTSNPEGAAVQRARTADGRTVAQLVIDEISQLNAGARPLGSVGLVVGATIGQTGHELAAVNGPLLAPGLGAQGASAADLRVVFGSSLPAVLPTYSREVLAAGPDVVALRGAADRVLADCRAALTGS
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: AROA_DEIRA
Sequence: MSDALPATFDVIVHPARELRGELRAQPSKNYTTRYLLAAALAEGETRVVGVATSEDAEAMLRCLRDWGAGVELVGDDAVIRGFGARPQAGVTLNPGNAGAVARFLMGVAALTSGTTFVTDYPDSLGKRPQGDLLEALERLGAWVSSNDGRLPISVSGPVRGGTVEVSAERSSQYASALMFLGPLLPDGLELRLTGDIKSHAPLRQTLDTLSDFGVRATASDDLRRISIPGGQKYRPGRVLVPGDYPGSAAILTAAALLPGEVRLSNLREHDLQGEKEAVNVLREMGADIVREGDTLTVRGGRPLHAVTRDGDSFTDAVQALTAAAAFAEGDTTWENVATLRLKECDRISDTRAELERLGLRARETADSLSVTGSAHLAGGITADGHGDHRMIMLLTLLGLRADAPLRITGAHHIRKSYPQFFAHLEALGARFEYAEATA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF4A_USTMA
Sequence: MSKPEDTSAAAAAPAGEAGNNLNIADGEIESNWETVIDNFDNMELKEELLRGVYAYGFERPSAIQARAIVPVIKGHDVIAQAQSGTGKTATFSIAILQRIDPSIKAVQALILAPTRELAQQIQKVVIALGDYMKIDCHACIGGTNVREDMAKLNEGAQVVVGTPGRVYDMINRRAFKTDQLKMFCLDEADEMLSRGFKDQMYEVFQLLPQDTQCVLLSATMPQEVLEVTKKFMRDPIRILVKRDELTLEGIKQFYVAVEKEDWKLDTLCDLYETVTITQAVIFCNTRRKVDWLTDKLTSREFTVSAMHGDMEQAQREVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFVTSDDVRMLRDIEQFYSTQIDEMPLNVADLI
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase eIF4A, Eukaryotic initiation factor 4A, eIF-4A, Translation initiation factor 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPL_DANRE
Sequence: MSQRVKKLTGLVAATFTPLTAEGEINLSVIAAYVDYLIEKQNVKSVFVNGTTGEGCSLTVDERKHLAAAWCQHGKGKLEQLIVHVGCMSIKDSQELARHAASIGADGISVISPSYFKPINADALRLFIKEVSASAPDLPMYYYHLPGMTGVALEAADVLNGIEREIPSFQGVKYSGTDLRDLGQCVCYSQSRDWSVLYGVDEQLLGALVLGVHGAVGSTYNYLGHIVNQMLSAFNNGNHTQTRDLQFGFMEVITFARTLGFDVSVNKQVMSEVSGLPMGPPRLPLLPCPVSKAQAIAQKIHNFTQGL
What is the function of this protein?
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.  It prevents sialic acids from being recycled and returning to the cell surface.  Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
What are the official names of this protein?
N-acetylneuraminate lyase, NALase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialate-pyruvate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCBP2_DROPE
Sequence: MATSVELSSYRDQHFKGSRSEQERSLKDSCTLYVGNLSFYTTEEQIHELFSRCGDVRLIVMGLDKYKKTPCGFCFVEYYIRSEAESAMRFVNGTRLDDRLIRVDWDAGFIEGRQYGRGKTGGQVRDEYRTDYDAGRGGYGKLLSLKIAPNTDNR
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi).  The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing.  Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 2, 20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, CBP20.
What is the protein family that this protein belongs to?
Belongs to the RRM NCBP2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YCIB_NEIMB
Sequence: MKFVSDLLSVILFFATYTVTKNMIAATAVALVAGVVQAAFLYWKYKKLDTMQWVGLVLIVVFGGATIVLGDSRFIMWKPSVLFWLGALFLWGSHLAGKNGLKASIGREIQLPDAVWAKLTYMWVGFLIFMGIANWFVFTRFESQWVNYKMFGSTALMLVFFIIQGIYLSTCLKKED
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1310_HAEIN
Sequence: MLLYKEKMKLLIKTSLSQWICLNFAKIPIFKMLGFITALFITACSSISKEPVKTVDIYIKPYYSAENGKAENVFVHKEIDPMLRENTIKGYKSAVKFVEENPARISPMTMFTLAARAYDFGLRDEAVTWFYRGQNRLITALYVLDLPKQTVQDNTGFSHVVGQFVNAYAFCNFDKQSLAAENAMKWTVAHPYEVVFLPALPAKFADRQKALKEAEEKLVQRLQEQARFFANPKNKEKWQKERSENFVNERFCW
What are the official names of this protein?
Uncharacterized protein HI_1310.
Protein: SEI1_ARATH
Sequence: MRILQNKTMKEQDNQLKIPEPLRADWFMVLVTIQADLIYNALVVLSSPFFLLYRSYRRAVVTVSAAEKAVKRAPAQIAGGAGRVVRRTWFGILGACHVSMVMVLALILAVVIGVGIVSLYVEKPVVVRDRLFFDYTEENPSAVFSFDKKKRSFSVPVGHSVHVSLVLWMPESEINRRIGVFQLKVELLSLKGETIARSSQPCMLRFRSKPIRLARTFVMSVPLIAGIANEAQTMRIDALKHQEKMPRTKAVRATLIPRAQTRTLPQLYEAEIVINSKPPWIKRMAYNWKWTLCVWTSMYLYVAILTALLWCFRPVLFPYTSSRTISESENLEIEVVEEEQEQVMERRRRERRNQPRRRNFATTQKSYT
What is the function of this protein?
Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size.  Facilitates the formation of large-sized LDs and modulates triacylglycerol accumulation.  Induces probably a reorganization of the endoplasmic reticulum into LD-forming domains.
What are the official names of this protein?
Seipin-1, AtSEIPIN1.
What is the protein family that this protein belongs to?
Belongs to the seipin family.
Protein: YBEY_THENN
Sequence: MIKILGEGKGKEILKSLSEKLDEIVKKEIGNVNTNVILVSKDQIKEMNREFRGEDFPTDVLTFPLFEEVYGEIYICPEVVEENAKEYNNTFEKELIEVVIHGILHLAGYDHEFEDKNAKEMFEKQHIYVEEVWNEWRSSLSGGTGQEGT
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD28_FELCA
Sequence: MILRLLLALNFFPSIQVTENKILVKQLPRLVVYNNEVNLSCKYTHNFFSKEFRASLYKGVDSAVEVCVVNGNYSHQPQFYSSTGFDCDGKLGNETVTFYLRNLFVNQTDIYFCKIEVMYPPPYIDNEKSNGTIIHVKEKHLCPAQLSPESSKPFWALVVVGGILGFYSLLATVALGACWMKTKRSRILQSDYMNMTPRRPGPTRRHYQPYAPARDFAAYRS
What is the function of this protein?
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.  Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.
What are the official names of this protein?
T-cell-specific surface glycoprotein CD28.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TENS2_MOUSE
Sequence: MKSSGPVERLLRALGRRDSSRATSRPRKAEPHSFREKVFRKKTPVCAVCKVTIDGTGVSCRVCKVATHRKCEAKVTSSCQALPPAELRRSTAPVRRIEHLGSTKSLNHSKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGSKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATELQPSQRRYVSYFSGLLSGSIRMNSSPLFLHYVFVPVLPAFEPNTGFQPFLKIYQSMQLVYTSGVYRIAGPGPQQLCISLEPALLLKGDVMVTCYHKGGQGTDRTLVFRVQFHTCTIHGSRLTFPKDQLDEAWADERFPFQASVEFVFSSSPEKVKGNTPRNDPSVSVDYNTTEPAVRWDSYENFNQHHEDSVDGALAHTRGPLDGSPYAQVQRVPRQTPPAPSPELPPPPMLSVSSDSGHSSTLTTEHTAESPGRPPPTAAERQELDRLLGGCGVASAGRGAGRETAILDDEEQPSVGGGLHLGMYSGHRPGLSRRCSCRQGFREPCGVPNGSYYRPEGTLERRRPPYGGYEGHPQGYAEASVEKRRLCRSLSEGPYPYAPELGKPANGDFGYRPAGYREVVILEDPGVPALCSCPACEEKLALPTAALYGLRLEREAAEGWSSEVGKPLLHPVRPGHPLPLLVPACGHHHAPMPDYGCLKPPKVGEEGHEGCSYAVCSEGRYGHSGYPALVTYGYGGAVPSYCPAYGRAPHSCGSPSEGRGYPSPGAHSPRAGSVSPGSPPYLQPRKLGYEISAEDGRDKYPLSGHLASTGPLASTESPEPSWRDGSSGHSTLPRSPRDPQCSASSELSGPSTPLHTSSPVQGKESNRRQDTTRSPSLAPTQRLSPGEALPSVVQGVAEKTPELLTSSRPEQLDPSPFSQTSAPGSPNGWPQERSPGGHTNSASPRSPVPTTLPGLRHAPWQGPRGTSDSPDGSPLTPVPTQMPWLVGSPEPPQSSPTPAFPLATSYDANGPIQPPLPEKRHLPGSGQQPSPPARSTNQHVTFASPLPDVTQPPEHPLQENQSNVKFVQDTSKFWYKPHLSRDQAIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPSEQLVRHFLIETGPKGVKIKGCPTEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETPEAPVPTNMSTAADLLRQGAACSVLYLTSVETESLTGPQAVAKASSAALSCSPVPVPAIVHFKVSAQGITLTDNQRKLFFRRHYPVNSITFSSTDPQDRRWTNPDGATSKIFGFVAKKPGSPWENVCHLFAELDPDQPASAIVTFITKVLLGQRK
What is the function of this protein?
Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (By similarity).  Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (By similarity).  In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy.  Negatively regulates PI3K-AKT pathway activation (By similarity).  Dephosphorylates nephrin NPHS1 in podocytes which affects mTORC1 complex activity (By similarity).  Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (By similarity).  Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (PubMed:27246398, PubMed:31723089, PubMed:32390516).  Enhances RHOA activation in the presence of DLC1 (By similarity).  Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (By similarity).
What are the official names of this protein?
Tensin-2, C1 domain-containing phosphatase and tensin homolog, C1-TEN, Tensin-like C1 domain-containing phosphatase.
What is the protein family that this protein belongs to?
Belongs to the PTEN phosphatase protein family.
Protein: ILVA_CORGL
Sequence: MSETYVSEKSPGVMASGAELIRAADIQTAQARISSVIAPTPLQYCPRLSEETGAEIYLKREDLQDVRSYKIRGALNSGAQLTQEQRDAGIVAASAGNHAQGVAYVCKSLGVQGRIYVPVQTPKQKRDRIMVHGGEFVSLVVTGNNFDEASAAAHEDAERTGATLIEPFDARNTVIGQGTVAAEILSQLTSMGKSADHVMVPVGGGGLLAGVVSYMADMAPRTAIVGIEPAGAASMQAALHNGGPITLETVDPFVDGAAVKRVGDLNYTIVEKNQGRVHMMSATEGAVCTEMLDLYQNEGIIAEPAGALSIAGLKEMSFAPGSVVVCIISGGNNDVLRYAEIAERSLVHRGLKHYFLVNFPQKPGQLRHFLEDILGPDDDITLFEYLKRNNRETGTALVGIHLSEASGLDSLLERMEESAIDSRRLEPGTPEYEYLT
What is the function of this protein?
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction.  The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate).  Both intermediates are unstable and short-lived.  The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia.  In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
What are the official names of this protein?
L-threonine dehydratase biosynthetic IlvA, Threonine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: SLX1_DROPE
Sequence: MPPPPEDEAIAHKGHFYGVYLLCSQSLDSRYRAKCYVGFTVNPKRRIKQHNRGCDFGGAKKTSKKGPWQMVMIVHGFPNNISALQFEWAWQQPTLSTRLKIFPDLKRKKPKETHFDYNFRILNRMLGVGPWHRLALTIRWLETDYERAFDLPIPCHMEIVSGKVSISASQRKLEEATGTAPPVAWAHECHLCMQSIEQPERSRLGCTNPTCRLTCHMLCLASYLLGDEPGQYIPIGGECPLCETRLSWSALLQRKRLQLGVPEEMQDNEEEDLSDDGPDVDSDVEVQEFSD
What is the function of this protein?
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SEC13_CANAL
Sequence: MVTIGNAHDDLIHDAVLDYYGKRLATCSSDKTIKIFDLDGTDNYKLITTLTGHEGPVWQVSWAHPKFGSILASCSYDGKALIWKEQPETQQWSIIAEHTVHQASVNSVSWAPHELGAVLLCTSSDGKVSVVDFNDDGTTSHVIFDAHAIGANSATWAPVSTSSKDSAALKQQRRIVSCGSDNLAKIWKYDAANNTYVEEAKLEGHTDWVRDVAWSPSNLIRSYIATASQDRTVLIWTQDRDGKWQKQLLTEEKFPDVCWRCSWSLSGNILAVSGGDNKVSLWKENLQGKWESAGEVDQ
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.  It also functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution (By similarity).
What are the official names of this protein?
Protein transport protein SEC13.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC13 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex.
Protein: CAPSD_TTVZ1
Sequence: MVWRRRWWRRRRRPVWRRRYRRWRRRRRWRRRPRRRRRPYRRRPYRRYGRRRKVRRRRRRTLVVRQFQPPYQRRCRVSGLEPLLYFGKKEEERHFYGNRQIMKDVDQTEGGGVTDGVFSLEELYESYQEGWNHWSASNQMLPLVRYFGCKITLYRSATDSYIFWWTNRPPFQVDRQFWVGMHPYWMLRRGRKVVMLSKQLKPFAKDHVTIKIGPPALMKTKWYFARDFCKTWLLQWRACFFNPIDPYIPRGANNTTVTFYGFPGHSYPSQSLYYTWQEHLAETNVWGITNESEKTKFEALRKAWNEQATKGPVAGYKAVLQAMNAWASVAAPGPEGSNFAKGTNVALGLANLLWLIYSQYYWQNRSPSPWGLPGATLEAMKHPEAWKPYAYKYSWSHDKGKGNRFAICDWPYKDQHGEQTTPLNFDLEIKDAPLWWCVTAAYDWAIRQGKNPANWSFFVRSDYTWPRADNIILAYSSYFADNVVKNKYADPQHATGGYFTLYRAPNLIDGREAIDIIYRNGPFAPKQEESTGNATIKYRFYFKWGGTQRPPRPQPTDPCQQPRWEGPNFPPFDGRARIDNPSDQDPRSYFWPFDTRRGSLTASAVDRVKRSLDAVTEPSETRLREGEETYGLPPPEKRARWGFPSILPTENPTDEDERYLEAEADTSSSDATDGVPETPFELLQHIQRDRDKRRELRGRLARLILRLRRRQDPELQNYYP
What is the function of this protein?
Self-assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins.  The capsid encapsulates the genomic DNA.  Capsid protein is involved in attachment and entry into the host cell (By similarity).
What are the official names of this protein?
Capsid protein.
What is the protein family that this protein belongs to?
Belongs to the anelloviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: SFR2_ORYSJ
Sequence: MPLPAFVAAAARLAVLVAAAATAANAASYARYRRRHLRRIPSPIDESADPLADFRAFPSSDADDSEEDNFFFGLATAPAHVEDRLEDAWLQFATETSCDDNGNVRDQRPVDALMASAAGDGGSQQSWRSTGGENIGDREQRKPLRVAMEAMLRGFEILAESGESAGGDNCSHNVAAWHNVPCPQERLRFWSDPDAELKLAKETGISVFRMGVDWARLMPEEPTEELKSSVNFAALERYRWIIQRVREYGMKVMLTLFHHSLPPWAGKYGGWKMEKTVTYFMDFVRLVVDRVSNLVDYWVIFNEPHVFVMLTYCAGAWPGGDPNAIEVATSTLPTGVYNQALHWMAIAHSEAYDYIHSKSKNERKPIVGVAHHVSFTRPYGLFDVAAVALANSLTLFPYVDSICDKLDFIGINYYGQEVISGPGLKLVDNDEYSESGRGVYPDGLFRILIQFNERYKRLNIPFVITENGVSDETDLIRKPYILEHLLATYAAIIMGVRVLGYLFWTTSDNWEWADGYGPKFGLVAVDRANNLARKPRPSYFLFSRVVTTGKITRQDRMSAWRELQQAAVQKKTRPFFRAVDKHGRMYAGGLDRPIQRPFILRDWRFGHYKMEGLQDPLSCFIRCIFAPFSRQKKIHYIEDDVISYSIN
What is the function of this protein?
Galactosyltransferase synthesizing digalactosyldiacylglycerol from monogalactosyldiacylglycerol in the absence of UDP-galactose (By similarity).  Potentially involved in freezing tolerance (PubMed:18466306).
What are the official names of this protein?
Beta-glucosidase-like SFR2, chloroplastic, Beta-glucosidase 36, Os11bglu36, Protein SENSITIVE TO FREEZING 2, OsSFR2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane.
Protein: RS19_BORPD
Sequence: MSRSIKKGPFVDAHLIKKVDTAVAGKDKKPIKTWSRRSTILPEFIGLTIAVHNGRQHVPVYINENMVGHKLGEFALTRTFKGHAADKKAKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.