PharMolix/UniProtQA huggingface dataset:
Protein: Y095_METJA
Sequence: MAIDISGRHHENDIFFRVYAGVLVEIKADRIVHVEKIDVMVKEEETQKLRDIVKEVKELIDKVGDEFDYILCERGEFFNISKDIISAILKKEVIFPKTRGELEAINIAHHVSYSVRKLLIEEKRKS
What are the official names of this protein?
Uncharacterized protein MJ0095.
Protein: IGNAR_GINCI
Sequence: LTFSTRSLLNLPAVEWKSGAKYTCTASHSPSQSTVKRVIRNPKESPKGSSETRKSPLEIMESPEDYGTEEDQLENVNEDSNSSLSIMTFVILFIL
What are the official names of this protein?
IgNAR transmembrane form NE.
Protein: RL24_DINSH
Sequence: MAAKLKKGDKVVVLAGKDKGKEGEITSVSPKTGKAVVDGLNIAIRHTRQSQNSQGGRIPQAMPIDLSNLALVDSNGKPTRVGFRMEDGKKVRFAKTTGEVV
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: ILVD_ACTP2
Sequence: MPILRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLRDMGKLVAEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKTKLSDQLIKLDLVDAMMKSADKTVCDDDVDAIEKSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLTAGRQIVELCKRYYEQDDASVLPRSIATKAAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLSKVAPNTNKYHMEDVHRAGGIMAILGELERADLLHSDTRTVLGMTIGEQIAKYDITLTKDEAVHKFFRAGPAGIRTTKAFSQDCRWDTVDDDRQNGCIRSKEFAYSQDGGLAMLTGNIALDGCIVKTAGVDESILKFTGDAIVFESQEEAVEGILGGKVRAGHVVIIRYEGPKGGPGMQEMLYPTTYLKSIGLGKECALLTDGRFSGGTSGLSIGHCSPEAASGGTIGLVRDGDKIAIDIPNRSIQLLVSDEELAVRRAEQDTKGWKPANRQREVSMALKMFGHFATSADKGAVRDKTKL
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: NUOD_BORPA
Sequence: MAEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEHKTFIQALPYMDRLDYVSMMCNEHAYVMAIEKLLGIEAPLRAQYIRVMFDEITRVLNHLMSLGSHALDVGAMAVFLYAFREREDLMDCYEAVSGARMHAAYYRPGGVYRDLPDTMPQYGDSSKYRGEKEVRAMNDARSGSLLDFIEDFTNRFPGCVDEYETLLTDNRIWKQRLVGIGVVDPDRAKALGFTGPMLRGSGVAWDLRKTQPYEVYDLMDFDVPVGVNGDCYDRYLVRVAEMRESNRIIRQCVEWLRNNPGPVMIENHKIAPPSRTAMKSNMEELIHHFKLFSEGFHVPPGEAYAAVEHPKGEFGIYLVADGANKPYRLKIRAPGFAHLQSLDEMARGHMIADAVTIIGTQDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GCSPA_HYPNA
Sequence: MRYLPLTPEDRANMLATIGAKSVDDFYTDVPDAARLKGKIAGLPDHQGELAVERHLTKLAAKNRSASSGPFFVGAGAYKHHVPATVDMIIQRSEFLTTYTPYQPEIAQGTLQTLFEFQTQVASLTAMDVANASMYDGSTSCAEAAVMAARVTRRKKIILSGGLHPHYAAATRLLAEAQGLTVVQLPVAIDGEGELAKAVDGETACVIGQSPNVFGTVTDLSAVADAAHGKGALLVSVFTEAVSLGLVTPPGEMGADIAAGEGQSIGNGLNFGGPYVGLFSCREKLVRQMPGRLCGETVDADGKRGFVLTLSTREQHIRRDKATSNICTNSGLCALAFTSHMTLLGGKGLKQLAELNHEAAIELADALGAVKGVEILTPRFFNEFAIRTPMDAEAVLAMLDEAGVVGGVRASRLFPGDHLGDVILVAATECTTADDIAAYTDALKEII
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: RECF_PAEAT
Sequence: MYLEHLSLTDFRSYAQVDLKLGPGVTVLVGSNGIGKTNLMEAIGYLATLSSHRVSTDAPLLRFGTERALIRAKLVRGEQSTVIELEINAGRANRGRINRSNPVRARDILGICQTVLFAPEDLALVKGDPSNRRRFLDELLVSLVPRHAATRSDYDRVLKQRNALLKSARTGKFTAGHEATLDVWDQHMARAGAELLHARLELVERLRPHLNSAYAQLTDASKDAGAVYRSTIQGVLDDDGGPTDHGTEPSPSVDDLRLLSVDELTERYVQAFAASRKKELERGISLVGPHRDELELVLGQAPAKGYASHGETWSMCLSLRLASYYVMLDDARTGGTAPILILILDDVFAELDVHRRRKLAAIVAGAEQVLVTAAVDADIPEELAGRRVTVVPGGIDGEG
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELO_ECO7I
Sequence: MTLSFITRWCDELPETYTALSPTPLNKARLIWHNAELANTLSIPSSLFKNGAGVWGGETLLPGMSPLAQVYSGHQFGVWAGQLGDGRGILLGEQQLADGTTMDWHLKGAGLTPYSRMGDGRAVLRSTIRESLASEAMHYLGIPTTRALSIVTSDSPVYRETVEPGAMLMRVAPSHLRFGHFEHFYYRREPEKVRQLADFAIRHYWSHLADDEDKYRLWFSDVVARTASLIAQWQTVGFAHGVMNTDNMSLLGLTLDYGPFGFLDDYEPGFICNHSDHQGRYSFDNQPAVALWNLQRLAQTLSPFVAVDALNEALDSYQQVLLTHYGQRMRQKLGFMTEQKEDNALLNELFSLMARERSDYTRTFRMLSLTEQHSAASPLRDEFIDRAAFDDWFARYRRRLQQDEVSDSERQQLMQSVNPALVLRNWLAQRAIEAAEKGDMTELHRLHEALRNPFSDRDDDYVSRPPDWGKRLEVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: PDXJ_COXBU
Sequence: MVRLGVNIDHIATLRQARGVDYPDPVEAAMMAIEAGADGITLHLREDRRHIQDDDVRNLKRKLTVPMNLEMATAEDIIQFAEEIKPEHCCLVPEKREELTTEGGLDVAGQQNTLKKVCARLAKVGIEVSLFIDPEEKQIDAAKAAGAPVIEIHTGHYANAKTDHEHNQQLKRIADAAAYADSLGLTVNAGHGLTIHNVQSIAAIPVINELNIGHSIISRGVLIGLAEAVKEMKTLIAGAQ
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_BURO1
Sequence: MNPEHSPLGKATVYAAQYDASLLFPIPRAGAREQLGITSALPFFGTDIWNAYELSWLNARGKPQVAIATFYVPAESPNIVESKSFKLYLGSFAQSKFDSVDAVRDVLKRDVSAACGASVSVQLVSPHDFAKLEMDELDGLSLDRLDLDTDVYEPDPSLLSAADGENEAPVEETLVSDLLRSNCPVTGQPDWGSVQIHYVGPQIDHAGLLRYIISFRNHTGFHEQCVERIFLDILHACKPVKLAVYARYTRRGGLDINPFRTNYNQPMPDNARTARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
Protein: PSD_RICAH
Sequence: MRQYNDLFKIIHREGYIFIASFALVSFLLASFNEKLGCIGFIATAWCIYFFRNPDRFVPISDDLVISPADGIIQEIKEALPPQELGLGDVEMIRVSIFLNIFNVHVNRIPANGKILALHYNPGKFFNASLDKASIYNERQSVLMETDKGQKIVFVQIAGLIARRIVCDLEEGNEVKTGERYGIIRFGSRVDVYLPLKTALLVSKGQTAIGGETIIADFGRKKIAEFKFERR
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y3523_XANC5
Sequence: MDLPDVTAVQHESRQLALASSAAELHGGLCGWLSGGGADSADWLARILADSGQVAPQQGGALDQLRQATVAQLEDRDFAFELLLVEDGAPLPARTDALFDWCRAFLGGFGLAAQQRPALSEEGEEALQDLARLAQASSEDFDAADEDDTALAEIEEFVRVAVLLLHGDCVMGPRFRQRLN
What are the official names of this protein?
UPF0149 protein XCV3523.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: DGK_DICDI
Sequence: MFRRSLMFMISNNKNTNMVSSINTTNKVNNFSKIIILEGNISAGKTYLSSKLGDLLGYKVFLEPTATNPYLSLFYKEPSKYALIMQKWLLNQRYNTFLNALQYSLENEQGVILDRSVYSDWVFAENCRSEGLISAEGFKEYNSIRDRFLSNIPIPNVTLFLDVDPKQCLQRIQNRKRDCEQSIPLSYLSGLDNCYKKFLIEMKSKGSNVIILDWNNFGDINLVLNEINNDNFNNFNNSNNSKFNDVNYKKQQLISDIENEKNNLKEMKFFLNENNNNNNQEKIKS
What is the function of this protein?
Purine-specific deoxyribonucleoside kinase that phosphorylates preferentially deoxyguanosine, as part of the deoxyribonucleotide salvage pathway.
What are the official names of this protein?
Deoxyguanosine kinase, dGK, DddGK.
What is the protein family that this protein belongs to?
Belongs to the DCK/DGK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_NITHX
Sequence: MSDLEQLQSQILADIASASDEAALEAVRVATLGKKGSISALLSTLGKMSPDERKSEGAKINLAKDTVTQALAARREVLKALALDARLASETIDVTLPLRESPAEAGRIHPLSQVWDEVTTIFADMGFAVAEGPDIETDDYNFTRLNFPEGHPAREMHDTFYFNPKEAAGSEAGEKPSRLLLRTHTSPVQVRTMLSQKPPIRVICPGRTYRSDSDQTHTPMFHQVEGLVIDKSSHLGHLKWILHEFCKAFFEVDNVNMRFRPSFFPFTEPSLEVDIQCRRDKNEIRFGEGEDWLEILGCGMVHPNVLKLCGLDPEVYQGFAWGMGIDRIAMLKYGIADLRQLFEGDVRWLNHYGFRPLEVPTLAGGLSS
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_ECOK1
Sequence: MSKPFKLNSAFKPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKAMLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMIIDQRAILRRLAELQYARNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQIVSTIPRFTIYPKTHYVTPRERIVQAMEEIKEELAARRKVLLENNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGGDVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGRGKSRPIVEPDNVPMDMSPKALQQKIHELEGLMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR4_LOTJA
Sequence: MSRYRGPRFKKIRRLGALPGLTSKRPTVGSELRNQSRSTKKSQYRIRLEEKQKLRFHYGLTERQLLKYVRIAGKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPQARQLVNHRHVFVNGHIVDIPSYRCKPQDIITAKDNKKSKTLIQNSLESAPREELPTHLTLQPFQYKGLVNQIIDSKWVGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SUCC_BACAA
Sequence: MNIHEYQGKAVLRSYGVSVPNGKVAFTVEEAVEAAKELGTDVCVVKAQIHAGGRGKAGGVKVAKNLDEVRTYAESILGTTLVTHQTGPEGKEVKRLLIEEGCDIKKEYYVGLVLDRATSQVVLMASEEGGTEIEEVAEKTPEKIFKEYIDPAVGLQGFQARRIAFNINIPKELVGQAVKFMMGLYRAFIEKDCSIAEINPLVTTGDGKVMALDAKLNFDSNALYRHKDILELRDLDEEDAKEIEASKYDLNYIPLDGNIGCMVNGAGLAMATMDIIKHYHGDPANFLDVGGGATAEKVTEAFKIILSDKNVKGIFVNIFGGIMKCDVIAEGVIEATKQVGLELPLVVRLEGTNVELGKKILNESGLNIVAAESMTDGAQKIVSLVG
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: MNMA_BORBU
Sequence: MKIAVLLSGGVDSSVALYRIINKGYSNIKCYYLKIWVEDELSYIGNCPWQEDLNYVEAICNKFNVPYEIINFQKEYYNKVVSYTIEELKNGNTPSPDIFCNQRIKFGAFFEKINSQYDLVVTGHYAKIQIKESKFLLKQAKDKIKDQSYFLSHLSQKQMSKLYFPLGTLLKSEVRQIAKNINLPNKDRKDSQGICFLGKIKYNEFIKYHLGEKKGNIIEKETGKIIGIHNGYWFFTVGQRRGIKLSNGPWFVIEKDLEKNIIYISHNENYLKQAKRKFLVHEIHWINDTPTNFENFKIKIRHGEKKYSCKLKLITNNLMEISLNKKDQGISPGQFAIFYKNTECLGGAKIFKIIE
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG04_GAHVM
Sequence: MWGRWGKKGNLANRTKLSVNRPRRWRGTRLGNRTQCREDALRRWRLGRAEEGMGSTDGRWWGRAELGAKLLRIGRSGGTDRRLEGGRPRSVDNMGSRDGRWWGRAELGAKFLRIGRRGGTDRRLGTGAMWSVRFIR
What are the official names of this protein?
Uncharacterized gene 4 protein.
Protein: CDS1_SCHPO
Sequence: MEEPEEATQATQEAPLHVSQNIAKQVVNNENVFMKLVMTRMLDGKTEVIPLTTDVHNGFWRFGRHKSCEVVLNGPRVSNFHFEIYQGHRNDSDESENVVFLHDHSSNGTFLNFERLAKNSRTILSNGDEIRIGLGVPKDEISFLCQVPVKHSRDSQKNMIKSENSHYEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSLHHPGVVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLHLHKQGVTHRDIKPENILITNDFHLKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNVNLDGGYDDKVDIWSLGCVLYVMLTASIPFASSSQAKCIELISKGAYPIEPLLENEISEEGIDLINRMLEINPEKRISESEALQHPWFYTVSTHEHRTPPSSSEHEATEQLNSSS
What is the function of this protein?
Has a role in the DNA replication-monitoring S/G2 checkpoint system.  It is responsible for blocking mitosis in the S phase.  It monitors DNA synthesis by interacting with DNA polymerase alpha and sends a signal to block the onset of mitosis while DNA synthesis is in progress.  Phosphorylates rad60 and dna2.
What are the official names of this protein?
Serine/threonine-protein kinase cds1, Checkpoint kinase cds1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
Protein: PLCD9_ARATH
Sequence: MVNLRKKFEMKQANQPGRVPNYFRNKYHGYDDDMPNLLPTFIKLLDTEKDEDGAGLNAAEQIDRELKSRKCDILKFRNLTILELPHLNEFLFSTELNPPISDQVRHRDMNAPLSHYFIHTSLKSYFTGNNVFGRLYSIEPIIDALKQGVRVVELDLLPFGKDGICVRPKWNFEKPLELQECLDAIKQHAFTPTRSYPVIITIKDSLKPDLQSKVTQMIDQTFGDMVYHEDPQQSLEEFPSPAELQNKILISRRPPTKLLYAKAVENGVELEIQEGSTDKNYQSVVGFHAVEPRGMLQKALTDDVQQPGWYERDVISFTQNKFLRTRPKKRNLLSNPPYKPQRAWMHGAQMIALSRQDDKEKLWLMQGMFRANGGCGYVKKPNFLLNAGSSGVFYPTENPVVVKTLKVKIYMGDGWIVDFKKRIGRLSKPDLYVRISIAGVPHDEKIMNTTVKNNEWKPTWGEEFTFPLTYPDLALISFEVYDYEVSTPDYFCGQTCLPVSELIEGIRAVPLYDERGKACSSTMLLTRFKWS
What is the function of this protein?
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
What are the official names of this protein?
Phosphoinositide phospholipase C 9, Phosphoinositide phospholipase PLC9, AtPLC9, PI-PLC9.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: IGF1B_CYPCA
Sequence: MSSGHFFQGHWCDVFKCTMRCLSCTHTLSLVLCVLALTPATLEAGPETLCGAELVDTLQFVCGDRGFYFSKPTGYGPSSRRSHNRGIVDECCFQSCELRRLEMYCAPVKPGKTPRSVRAQRHTDSPRTAKKPLPGQSHSSYKEVHQKNSSRGNTGGRNYRI
What is the function of this protein?
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.  Acts as a ligand for IGF1R.  Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways.  Binds to integrins.  Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.
What are the official names of this protein?
Insulin-like growth factor I, juvenile form.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: STHA_VIBCH
Sequence: MGQKNHFDVIVIGSGPGGEGAAMGLTKGGKNVAIIEKESSVGGGCTHWGTIPSKALRHAVSRIIEFNSNPLFCKNNSSIHATFSTILSHAKSVIDKQTRLRQGFYDRNQCTLIFGAAHFIDAHTVAVKKADGSIDTYSADKFVIATGSRPYHPKDVDFGHPRIYDSDSILNLEHDPRHIIIYGAGVIGCEYASIFRGLDVKTDLINTRDRLLSFLDNEVSDALSYHFWNSGVVIRNDETYDKVEGTSDGVIVHLKSGKKMRADCLLYANGRTGNTDKLNLESVGLQADSRGQLVVNANYQTQVEHIYAVGDVIGYPSLASAAYDQGRFVAQAIIHGQAAHLLTEDIPTGIYTIPEISSVGRTEQELTAAKVPYEVGRASFKHLARAQIAGKDIGSLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAFRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TEFF2_BOVIN
Sequence: MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNSDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDFAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGHYSSDNTTRASTRLI
What is the function of this protein?
May be a survival factor for hippocampal and mesencephalic neurons.  The shedded form may up-regulate cell proliferation (By similarity).
What are the official names of this protein?
Tomoregulin-2, TR-2, Transmembrane protein with EGF-like and two follistatin-like domains.
What is the protein family that this protein belongs to?
Belongs to the tomoregulin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GALR2_RAT
Sequence: MNGSGSQGAENTSQEGGSGGWQPEAVLVPLFFALIFLVGTVGNALVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLALLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDLCTFVFSYLLPVLVLSLTYARTLRYLWRTVDPVTAGSGSQRAKRKVTRMIIIVAVLFCLCWMPHHALILCVWFGRFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRKICAGLLRPAPRRASGRVSILAPGNHSGSMLEQESTDLTQVSEAAGPLVPPPALPNCTASSRTLDPAC
What is the function of this protein?
Receptor for the hormone galanin, GALP and spexin-1.  The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
What are the official names of this protein?
Galanin receptor type 2, GAL2-R, GALR-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ZP1_RABIT
Sequence: MTGGRLVALLLLVAASLGLGQQPHPEPGLPGLQYSYDCGMRGMQLVVLPRPGRTIRFKVVDEFGNRFEVNNCSICFHWVSAEPQAPAVFSADYKGCHVLEKEGHSHLTVFIEAMLPDGHVEVAQEAVLICPKPGHTWAVGSHQVPPTTPSPTTPHALPFHLSSAHTFPIPLYLEHSLMLPTPAGPSLGPGPTPAVLAQVERWEVDKPDAVGSHLPQEWCQVASGHIPCIVQSSSKEACEQAGCCYDSAREVPCYYGNTATVQCFRNGYFILVVAQEMALAHRITLANVHLAYAPTRCPPAQKTSAFVIFHVPLTHCGTTVQVLGSQLFYENQLVSDIDVREGPQGSITRDSSFRLLVRCIFNASDFLPIQASIFSPPLPAPVTQAGPLRLELRIARDETFSSFYEEEDYPLVRLLREPVHVEVRLLQRTDPSLVLELHQCWATPSANPVQQPQWPLLSDGCPFKGDSYRTRVLALDRAELPFRSHYQRFTVATFTFLDSGAQRALRGLVYFFCSASACHPSGPETCSSTCSSRTAKRRRSSGYHDGTPRALDIVSSPGPVGFQDSHRQEPTLESTGSGRNSNPKPLLWVVLLLLAIALVLGIGVFVGLSQAWAHKLREGHRLTDQAQ
What is the function of this protein?
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy.  The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4.  ZP1 ensures the structural integrity of the zona pellucida (By similarity).
What are the official names of this protein?
Zona pellucida sperm-binding protein 1, Zona pellucida glycoprotein 1, Zp-1.
What is the protein family that this protein belongs to?
Belongs to the ZP domain family. ZPB subfamily.
What are the subcellular locations of this protein?
[Processed zona pellucida sperm-binding protein 1]: Zona pellucida. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Protein: Y2623_MYCTU
Sequence: MSSGNSSLGIIVGIDDSPAAQVAVRWAARDAELRKIPLTLVHAVSPEVATWLEVPLPPGVLRWQQDHGRHLIDDALKVVEQASLRAGPPTVHSEIVPAAAVPTLVDMSKDAVLMVVGCLGSGRWPGRLLGSVSSGLLRHAHCPVVIIHDEDSVMPHPQQAPVLVGVDGSSASELATAIAFDEASRRNVDLVALHAWSDVDVSEWPGIDWPATQSMAEQVLAERLAGWQERYPNVAITRVVVRDQPARQLVQRSEEAQLVVVGSRGRGGYAGMLVGSVGETVAQLARTPVIVARESLT
What is the function of this protein?
May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent.  Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function.
What are the official names of this protein?
Universal stress protein Rv2623, USP Rv2623.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.