PharMolix/UniProtQA huggingface dataset:
Protein: TREF_SALEP
Sequence: MLNQKLNPTPSEDLTIDVDLLYETDPCELKLDEMIEAEPEPEMIEGLPASDALTPADRYLELFEHVQSTKLFPDSKTFPDCAPKMDPLDILIRYRKVRRHRDFDLRRFVENHFWLPETLSSEYVSNPENSLKEHIDQLWPILTREPQDHIPWSSLLALPQSYIVPGGRFSETYYWDSYFTMLGLAESGREDLLKCMADNFAWMIENYGHIPNGNRTYYLSRSQPPVFALMVELFEEDGVRGARRYLDHLKMEYAFWMDGAESLALNQAYRHVVRMPDGSLLNRYWDDRDTPRDESWLEDVETAKHSGRPPNEVYRDLRAGAASGWDYSSRWLRDAGRLASIRTTQFIPIDLNAFLYKLESAIANISALKGERDTEALFRQKASDRRAAVNHYLWDDENGCYRDYDWRREEMALFSAASIVPLYVGMANHEQADRLANVVRSRLLTPGGIMATEYETGEQWDKPNGWAPLQWMAIQGFKRYGDDMLGDEIAHNWLKTVNHFYQEHHKLIEKYHISGGTPREGGGGEYPLQDGFGWTNGVVRRLIGLYGEP
What is the function of this protein?
Hydrolyzes trehalose to glucose.  Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
What are the official names of this protein?
Cytoplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXK_ALIFM
Sequence: MIEKIWFDNHFLGKLLWPLLWPLSCLFKWIATKRKSDYQSGKKQSYRSSVPVVVVGNITAGGNGKTPVVVWLVEQLQSKGYKVGVASRGYGGKAPHYPYLLTETTTPDISGDEPVLIKQRTKAEVAVAPVRSEAVKMLEQQGVDFIITDDGLQHYALQRDIEFIVIDGKRRFGNQHYIPLGPLREGVERLSSVDFLICNGGEPQENEVSMRLQPSEAINLVTGERRSVSSLSNLVAFAGIGHPPRFFETLNQLKANVVHTQGFEDHKAFEPTEIEQLMQYGEQLIMTEKDAVKCQSFAQSSWWYLPVDATFPEEKAQQILNKIIEVKE
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: GCH4_PSEA7
Sequence: MNALTLPDIARQTTLSTLPLDWVGMQGIALPVQVAGQTVAAEADAGVSLDDPQARGIHMSRLYLALAGLEDGELDLPRLRGVLQRFLDSHADLSRRAYLRLRLAPLLRRPALVSPLSGWKRYPLVLDTRLENGTFQADLHLELTYSSTCPCSAALARQLIQERFAQDFAGQQPDHATILAWLGSSDGIVATPHSQRSSAQLRIGLAEDCAGLPLEELADLGECALGTAVQTAVKRADEQAFALANGQNLMFCEDAVRRLHRALRGYPQAREFSVRVVHAESLHAHDAVAESHWQRGAA
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: MNHD1_STAES
Sequence: MIESNLLVLTLVIPILTAILLIFIGKRPIIKRYVALVGTLLTLVIALINLKNVLRDGPIKVELGSWKAPYSIVFVVDIFSALLIITSIIITILVILYSYRSIGLDRERHYYYFSIMFMLIGIIGSFTTGDIFNLFVFFEVFLMSSYCLLVIGTTKIQLQETIKYILVNVVSSSFFVMGVAVLYSVVGTLNLAHISERLSQLSVHDSGLVNIVFILFIFVFATKAGVFPMYVWLPGAYYAPPVAIITFFGALLTKVGVYAIARTLSLFFNNTVSFSHYVILFLALLTIIFGCIGAIAYYDTKKIILYNIMIAVGVILVGIAMMNESGMTGAIYYTLHDMLVKASLFLLIGVMYKITKTTDLRHFGGLIKGYPILGWTFFIAALSLAGIPPFSGFYGKFYIVRATFEKGFYLSGIIVLLSSLIVLYSVIRIFLKGFFGEVEGYTLSKKVNVKYLTTIAVASTVITVIFGLSADTLFPIIKDGAETFVDPSQYIHSVLGGK
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit D1, Mnh complex subunit D1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DHYS_AERPE
Sequence: MEEVRDCRLEEGLSVEGLVECYRDIHGFMAGHLAEAVEVLREGLEASSVRVLTFTGNLVATGLRGVLAQLIDGGLFNVVFTTAGALDHDIARFMGGKYLKGRFEADDTELHRRGVHRLGNVFIPVESYGPLVERFVRTLAEQAAGVRGEWGVYELLRLAGSLMEGDRDSILAAAARRGVDVFVPGWPDGAFGTSLFMERQRGTSITVDYFRDMARLADIFFPQEGEAAALIVGGGISKHHAIWWSQFRGGLDYAVYVTTAVEYDGSLSGAHPREAVSWGKIKESSRRVVVYGDATITLPVIAYCLLHGCG
What is the function of this protein?
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
What are the official names of this protein?
Probable deoxyhypusine synthase, DHS.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: COBT_PSEA8
Sequence: MSLQWWRDTCREADPQMRRRAAERQDRLTKPRGSLGRLEQVAIDLAALQGRERPSLERIWVTVFAGDHGVVAEGISAYPQAVTGEMLRNFVRGGAAISVLARELGAGLEVVDLGTAFPLEALPGVRHLRLAAGTANFVEAPAMGAEQCLLALEAGRESVRRAEQAGSQLFIGGEMGIGNTTAAAAMACALLDAPASALVGPGTGLDASGVAHKAAVIERALALHGAHRADPFETLRRLGGLEIAALAGAYLACAQKGMVALVDGYICSVAALCAVRLNPACRDWLLFAHSGAEPGHRHVLEALAAQPLLDLGLRLGEGSGAALAVPLLRQACVLHAGMATFAEAAVSDRPA
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: A1H1_LOXRE
Sequence: ANKRPAWIMGHMVNAIYQIDEFVNLGANSIETDVSFDKDANPEYTYHGVPCDCGRSCLKWEYFSDFLKGLRKATTPGDSKYHAKLVLVVFDLKTGSLYDNQAYDAGKKLAKNLLKHYWNNGNNGGRAYIVLSIPDLNHYKLITGFKETLKSEGHPELMDKVGHDFSGNDAIGDVGNAYKKAGVTGHVWQSDGITNCLLRGLSRVKDAVKNRDSSNGFINKVYYWTVDKRATTREALDAGVDGVMTNYPDVITDVLNESAYKAKFRIATYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It also acts on a broad range of lysophospholipids, like lysophosphatidylinositol (LPI), lysophosphatidylglycerol (LPG), lysophosphatidylethanolamine (LPE), lysobisphosphatidic acid (LBPA), lysophosphatidylserine (LPS) and lysophosphatidylcholines (LPC) of varying chain lengths (By similarity).  The substrate preference is LPI > LPG > LPS > LPC >> LPE, LBPA (By similarity).  Furthermore, the enzyme also act on cyclic phosphatidic acid and lyso-platelet activating factor (LPAF, an alkyl-LPC) (By similarity).  The enzyme does not act on sphingosylphosphorylcholine (SPC, also known as lyso-sphingomyelin) and PAF (By similarity).  The toxin may also act on ceramide phosphoethanolamine (CPE) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  It does not exhibit detectable PLA1/2 activity (By similarity).  It induces dose-dependent hemolysis and dermonecrosis (By similarity).  Also induces increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LrSicTox-alphaIA1i, Lr2, Phospholipase D, PLD, SMaseD/LysoPLD, Sphingomyelin phosphodiesterase D 2, SMD 2, SMase D 2, Sphingomyelinase D 2.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NU1C_LEPBY
Sequence: MNPGIDLQGTFIETVQSLGIPAGAAKALWMPLPMLIMLLAATVSVLVVVWLERKISAAAQQRIGPEFIGPLGVLAPLADGLKLVLKEDVVPAKADKLLFTLGPAIVVIPVFLSYLILPFGQNLQITDVGLGIFLWIALSSVVPIGLLMSGYASNNKYSLLGGLRAAAQSISYELPLALSVLAVVMMSNSLSTVDIVNQQAGYGILGWNIWRQPVGFIIFWIAALAECERIPFDLPEAEEELVAGYQTEYSGMKFALFYLGSYVNLTLSALLFAVLYLGGWEFPISLSVISGLIGVPESTPWLQLIFATIGIGMTLLKAYFLIFLAILMRWTVPRVRIDQLLDLGWKFLLPVSLVNLLITAGLKLAFPVAFGG
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, NAD(P)H dehydrogenase I subunit 1, NDH-1 subunit 1, NDH-A.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: AN_HHV8P
Sequence: MEATPTPADLFSEDYLVDTLDGLTVDDQQAVLASLSFSKFLKHAKVRDWCAQAKIQPSMPALRMAYNYFLFSKVGEFIGSEDVCNFFVDRVFGGVRLLDVASVYAACSQMNAHQRHHICCLVERATSSQSLNPVWDALRDGIISSSKFHWAVKQQNTSKKIFSPWPITNNHFVAGPLAFGLRCEEVVKTLLATLLHPDEANCLDYGFMQSPQNGIFGVSLDFAANVKTDTEGRLQFDPNCKVYEIKCRFKYTFAKMECDPIYAAYQRLYEAPGKLALKDFFYSISKPAVEYVGLGKLPSESDYLVAYDQEWEACPRKKRKLTPLHNLIRECILHNSTTESDVYVLTDPQDTRGQISIKARFKANLFVNVRHSYFYQVLLQSSIVEEYIGLDSGIPRLGSPKYYIATGFFRKRGYQDPVNCTIGGDALDPHVEIPTLLIVTPVYFPRGAKHRLLHQAANFWSRSAKDTFPYIKWDFSYLSANVPHSP
What is the function of this protein?
Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules.  Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate.  Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides.  Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.  Also acts as a cytoplasmic RNA endonuclease that induces degradation of the majority of the cellular messenger RNAs during early lytic infection.  The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and evasion from host immune response.  Internally cleaves host mRNAs which are then degraded by the cellular exonuclease XRN1.  Bypasses therefore the regulatory steps of deadenylation and decapping normally required for XRN1 activation.
What are the official names of this protein?
Shutoff alkaline exonuclease, SOX.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae alkaline nuclease family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: Y1649_GLAP5
Sequence: MSLQFNSVALLLVALILLGIFSQNSAVTISAAVLLIMQQTLLSKYVPYLEQYGIKIGIIILTIGVLAPLVSGRIALPELVQLINWKMIVAIIAGIVVAWLGGRGVTLMGNQPVLVTGLLIGTIIGVAFLKGVPVGPLIAAGILSLIIGKS
What are the official names of this protein?
UPF0756 membrane protein HAPS_1649.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PARC_STAES
Sequence: MSEIIQDLSLEDVIGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMYSSGNTYDKNFRKSAKTVGDVIGQYHPHGDSSVYDAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYTEAKLSQLSEELLRDINKETVSFIPNYDDTTLEPMVLPARFPNLLINGSTGISSGYATDIPPHNLAEVIQGTLKYIDQPDITINQLMKYIKGPDFPTGGIIQGIEGIKKAYETGKGKVVVRSRVDEEPLRSGRKQLIVTEIPYEVNKSSLVKKIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDANSESIKNYLYKNSDLQISYNFNMVAISEGRPKLMGLREIIESYLNHQIEVVTNRTRYDLEQAEKRMHIVEGLMKALSILDEVIALIRNSKNKKDAKDNLVAEYDFTEAQAEAIVMLQLYRLTNTDIEALKKEHEELEALIKELRNILDNHEALLAVIKDELNEIKKKFKVDRLSTIEAEISEIKIDKEVMVPSEEVILSLTQHGYIKRTSTRSFNASGVTEIGLKDGDRLLKHESVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHISQIVPIDEDEEVVNVYNEKDFKNEAFYIMATKNGMIKKSSASQFKTTRFNKPLINMKVKDKDELINVVRLESDQLITVLTHKGMSLTYSTNELSDTGLRAAGVKSINLKDEDYVVMTEDVNDSDSIIMVTQRGAMKRIDFNVLQEAKRAQRGITLLKELKKKPHRIVAGAVVKENHTKYIVFSQHHEEYGNIDDVHLSEQYTNGSFIIDTDDFGEVESMILE
What is the function of this protein?
Topoisomerase IV is essential for chromosome segregation.  It relaxes supercoiled DNA.  Performs the decatenation events required during the replication of a circular DNA molecule.
What are the official names of this protein?
DNA topoisomerase 4 subunit A, Topoisomerase IV subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: S35E1_DROME
Sequence: MLGKRTGSRHIAVVLLMCLFWYVISSSNNVIGKMVLNEFPFPMTVTLVQLCSITLYSGPFFNLWRIRKYQDIPRPYYYRLIVPLALGKLLASVTSHISLWKVPVSYAHTVKATMPLFTVVLTRVFFGEKQPTLVYLSLLPIITGVGIATVTEISFDMMGLISALISTMGFSMQNIFSKKVLKDTNIHHLRLLHLLGKLSLFIFLPLWLYMDSFAVFRHTAIKNLDYRVIALLFADGVLNWLQNIIAFSVLSLVTPLTYAVASASKRIFVIAVSLLILGNPVTWVNCVGMTLAIVGVLCYNRAKQLTRGREQPTLPLSQTSYVKYSPLEQQADPYYRGSVNGKLSNGLHRTPGNSLLANGSGMPSGTATRLLFV
What is the function of this protein?
Putative transporter.
What are the official names of this protein?
Solute carrier family 35 member E1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35E subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DNCH_THEVB
Sequence: MNPTPLRDYQRTVHFADTDAAGVVYFANLLRFCHEAYEDALAQLGVDLRQFFSNSGLIVPITEAQIRFLKPLYCGDRLRVTIDPQRLDTSRFQLTYTLYNEGGDRVAIAQTQHMCLQLPHRQRVPIPDPLPAWLKSAPEEASDRED
What is the function of this protein?
Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA hydrolase, DHNA-CoA hydrolase, DHNA-CoA thioesterase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
Protein: DAPD_YERE8
Sequence: MQQLQNVIETAFERRADITPANVDTVTREAINHVIDLLDTGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVMEGAETRYYDKVPMKFAGYDEARFQREGFRVVPPATVRKGAFIARNTVLMPSYVNIGAFVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFVGARSEVVEGVIVEEGSVISMGVFIGQSTRIYDRETGEIHYGRVPAGSVVVSGNLPSKDGSYSLYCAVIVKKVDAKTRGKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYD_FUSNN
Sequence: MVYRTHNLGELRLKNIGEVVTLSGWVDTKRNVSTNLTFIDLRDREGKTQIVFNNELLSEKVLEEVQKLKSESVIRVIGEVKERSNKNPNIPTGEIEVFAKEIEILNACDTLPFQISGVDDNLSENMRLTYRYLDIRRNKMLNNLKMRHRMIMSIRNYMDNAGFLDVDTPVLTKSTPEGARDFLVPSRTNPGTFYALPQSPQLFKQLLMIGGVEKYFQIAKCFRDEDLRADRQPEFTQLDIEMSFVEKEDVMNEIEGLAKYVFKNVTGEEANYIFQRMPYAEAMDRFGSDKPDLRFGVELKDLSDIINNSSFNAFSSTVQNGGLVKAVVAPNANEKFSRKVISEYEEYVKTYFGAKGLAYIKLTADGIASPIAKFLSEEEMKAIIEKTEAKTGDVIFIVADKKKVVHSALGALRLRIGKDLELINKDDFKFLWVVDFPMFDYDEEEQRYKAEHHPFTSIKAEDLDKFLAGQTEDIRTNTYDLVLNGSEIGGGSIRIFNPQIQSMVFDRLGLSQEEAKAKFGFFLDAFKYGAPPHGGLAFGIDRWLMVMLKEESIRDVIPFPKTNKGQCLMTEAPNTVDEKQLEELFIKSTYEK
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBDZ_BACSU
Sequence: MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGREACLDYIQSHWSDMRPNSLKTVENV
What are the official names of this protein?
Uncharacterized protein YbdZ.
Protein: NEF_HV1SE
Sequence: MGGKWSKSSIVGWPEVRERIRNTPTAAEGVGAVSQDLDRHGAITSSNTAANNPDCAWLEAQEEDSEVGFPVRPQVPLRPMTFKGAFDLSFFLKEKGGLDGLIYSKKRQEILDLWVYNTQGYFPDWQNYTPGPGTRFPLTFGWCFKLVPMDPAEVEEANKGENNSLLHPICQHGMEDEDREVLVWRFDSSLARRHIARELHPEYYKDC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: TGT_EDWI9
Sequence: MKYELVSTDGRARRGRLIFERGVVETPAFMPVGTYGTVKGMTPEEVAQTGAQILLGNTFHLWLRPGQEIMKLHGDLHDFMQWPGPILTDSGGFQVFSLGAMRKIKEEGVYFRNPINGSPVFLSPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRQRFDELGNQNALFGIIQGSVYEDLRDVSLKGLVEIGFDGYAVGGLAVGEPKEDMHRILEHVCPMIPQDKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTGGVVKIRNAQYKEDTTALDPECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAALRQAIEEGKLERFAADFYGRRGRTVPPLGAADAAS
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RLMF_SALPB
Sequence: MSAQKPGLHPRNRHQHRYDLAALCQTTPELTSFLIRTPAGEQSVDFANPQAVKALNKALLAHFYAVTHWDIPPGFLCPPVPGRADYIHHLADLLGETTGSIPAQATILDVGVGANCIYPLIGVHEYGWRFTGSEVSDAAMSSAQAIIQANTGLSRAIRLRRQKDPAAIFTGIIHKNEFYDATLCNPPFHDSAAAARAGSERKRRNLGQNKDDALNFGGQQQELWCEGGEVAFIKKMIAESQTFRRQVLWFTTLVSRGENLPPLYRALTEAGAVKVVKKEMAQGQKQSRFIAWTFMGDDQRRRFITRKR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_PHOPR
Sequence: MINEIQNDAQERMGKSVDALKNQLVKIRTGRAHPSLLDTIYVEYYGANTPLKQLANVVAEDSRTLAITVFDRELTPKIEKAIMMSDLGLNPMSAGTVIRVPLPPLTEERRRDLVKIVRKEAEQGRVAIRNIRRDANADLKALLKDKEISEDDDRRAQDEIQKLTDVAVKNIEAVLEVKEKELMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIPA_HAEIG
Sequence: MDLNTILIIVGIVALVALIVHGLWSNRREKSKYFDKANKFDRTSLTSRSHTQEEMVQPNNISPNTYVENGHTPISQPTTEKLPSEAELIDYRQSDKSVDDIKISIPNTQPIYDMGNHRSEPIQPTQPQYDMPTANNVASMTLEQLEAQSQNVGFNGINSSSPELRVQLAELSHEEHQVDYNLSFNEPKAETTAQPKQTTGYIQLYLIPKSSEEFNGAKLVQALENLGFILGKDEMYHRHLDLSVASPVLFSVANLEQPGTFNAYNLAEFNTIGIVLFMQLPSPGNNLANLRMMMRAAHTLAEDLQGVILTEEQEIFDANAEQAYLARV
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: OVCA2_HUMAN
Sequence: MAAQRPLRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVPDPPGPEGARSDFGSCPPEEQPRGWWFSEQEADVFSALEEPAVCRGLEESLGMVAQALNRLGPFDGLLGFSQGAALAALVCALGQAGDPRFPLPRFILLVSGFCPRGIGFKESILQRPLSLPSLHVFGDTDKVIPSQESVQLASQFPGAITLTHSGGHFIPAAAPQRQAYLKFLDQFAE
What are the official names of this protein?
Esterase OVCA2, Ovarian cancer-associated gene 2 protein.
What is the protein family that this protein belongs to?
Belongs to the LovG family.
Protein: NDUS4_HUMAN
Sequence: MAAVSMSVVLRQTLWRRRAVAVAALSVSRVPTRSLRTSTWRLAQDQTQDTQLITVDEKLDITTLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADPLSNMVLTFSTKEDAVSFAEKNGWSYDIEERKVPKPKSKSYGANFSWNKRTRVSTK
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial, Complex I-18 kDa, CI-18 kDa, Complex I-AQDQ, CI-AQDQ, NADH-ubiquinone oxidoreductase 18 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFS4 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=The interaction with BCAP31 mediates mitochondria localization.
Protein: VU54_HHV6Z
Sequence: MQPATLQWSSYVLQLRLTTAAILKPGELRYFKCGLGICPPSSSVVCTCRDESSFAASPFTYIDPKDYGNIPFAVHNISDLDLDLGRLPIVLNIFALPYANVTVSNLPVQRIEAYDRHAIPHGQCEAQFILYGPLTRIKIYAADIRWTEKTPEEPTRYLFNADIWINLQNTPLDQIFNSAKIEFISHRHVSISRILLCGNLLILKTVYENDYLLDDTFFPEKLNIQLSLTPHTADITMSQNQETLLKCNVGSITVGATKNIVSNLITPFHCSFHTIFESNSNFTGFFIPKLLHGISITTCIWDETRPLYITMKAQKKNCRINYSQELGKVFFFPKQILPPGNNIEFSWTEMSNIYVNIESPNGPVKDIVALASQPVSRAPSLTTVAHVTPEISMGIFLKSLRIAFDKEHLVPLHFFLKPGESTRMEFMPPETPQSLTILEGDVGIRFIPCHNNYSHRSSP
What are the official names of this protein?
Protein U54.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL82 family.
Protein: RS12_ACIB5
Sequence: MATTNQLIRKGRTTLVEKSKVPALKACPQRRGVCTRVYTTTPKKPNSAMRKVCRVRLTSGFEVSSYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGSLDCAGVKDRNQSRSKYGAKRPKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: QUEC_BACFR
Sequence: MKNDSAVVLFSGGQDSTTCLFWAKKHFKKVYALSFLYGQKHAHEVELARGIAERAGVEFHVMDTSFIGSLGSNSLTDTSISMDEDKPKDSFPNTFVPGRNLFFLSIAAVFAREQGAFHLVTGVSQTDYSGYPDCRDSFIKSLNVTLNLAMDEQFVIHTPLMWIDKAETWALADELGVFDLVRNETLTCYNGIPADGCGHCPACKLRKQGLEEYLSKRNR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.