PharMolix/UniProtQA huggingface dataset:
Protein: MTAP1_PUCGT
Sequence: MTGHAPLVGVIGGSGLYKLEGIEPVESLNIDTPWGRPSSPITLFKLPSGPVVAFLARHGVSHQFTPSEVPSRANIAALKKIGCQVIIAFSAVGSLREEIKPRDIVVPSQIIDRTKSVRPCTFFEGLGVVGHAMFGEPFDTELTGLVTKSIKEAVTGFEMNDRIGVHAEKVAICMEGPAFSTRAESNMYRMFGGDIINMSVLPEAKLAREAELSYALIAQITDYDAWRESEEPVTVAEVMATIAANVSVSNRLTLTILDEVHNAVAKGQLKTCKGTMEYSVMTKKEMISEESKKTLSFILPYFS
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase 1, 5'-methylthioadenosine phosphorylase 1, MTA phosphorylase 1, MTAP 1, MTAPase 1.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RSMH_DECAR
Sequence: MTRSTAHVTVLLEEAVGALAIKADGVYVDATFGRGGHSRRILSELNQNGRLVAVDRDPQAIAAGAEIDDSRFLLVHRAFGELAEAADEAGIRDVDGVLFDVGVSSPQIDDGERGFSFRYDAPLDMRMDTTQGETAAEWLARAEIRDITEVIRNYGEERFAFQIAKKVVAARLEQPIVTTGQFAALVRETVRTREPGQDPATRSFQALRIHINQELRQLEVALPQALELLKPGGRLVVISFHSLEDRIVKNFMRDQSIADAMPKSLPLRADQLPKPKLRLVGRPIKPSAAEIDANPRARSAVMRIAEKL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_BURMS
Sequence: MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPGPGLGVRILGEVKRDYAELLRRADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RL19_HAEIE
Sequence: MSNIIKQLEQEQLKQNVPSFRPGDTLEVKVWVVEGSKRRLQAFEGVVIAIRNRGLHSAFTLRKVSNGVGVERVFQTHSPAVDSIAVKRKGAVRKAKLYYLRERSGKSARIKERLGA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: VP3_BTV1A
Sequence: MAAQNEQRPERIKTTPYLEGDVLSSDSGPLLSVFALQEIMQKVRQVQADYMTATREVDFTVPDVQKILDDIKALAAEQVSKIVKMPSISFRHIVMQARDRVLRVDTYYEEMSQVGDVITEDEPEKFYSTIIKKVRFIRGKGSFILHDIPTRDHRGMEVAEPEVLGVEFKNVLPVLTAEHRAMIQNALDGSIIENGNVATRDVDVFIGACSEPVYRIYNRLQGYIEAVQLQELRNSIGWLERLGQRKRITYSQEVLTEFRRQDTIWVLALQLPVNPQVVWDVPRSSIANLIMNIATCLPTGEYIAPNPRISSITLTQRITTTGPFAILTGSTPTAQQLNDVRKIYLALMFPGQIILDLKIDPGERMDPAVRMVAGVVGHLLFTAGGRFTNLTQNMARQLDIALNDYLLYMYNTRVQVNYGPTGEPLDFQIGRNQYDCNVFRADFGSGAGYNGWATIDVEYREPAPYVHAQRYIRYCGIDSRELINPTTYGIGMTYHCYNEMLRMLVAAGKDSEAAYFRSMLPFHMVRFARINQIINEDLHSVFSLPDDMFNALLPDLIAGAHQNADPVVLDVSWISLWFAFNRSFEPTHRNEMLEVAPLIESVYASELSVMKVDMRHLSLMQRRFPDVLIQARPSHFWKAVLNDSPEAVKAVMNLSHSHNFINIRDMMRWVMLPSLQPSLKLVLEEEAWAAANDFEDLMLTDQVYMHRDMLPEPRLDDVERFRQEGFYYTNMLEAPPEIDRVVQYTYEIARLQANMGQFRAALRRIMDDDDWVRFGGVLRTVRVKFVDARPPDDVLQGLPFSYDTNEKGGLAYATIKYATETTIFYLIYNVEFSNTPDSLVLINPTYTMTKVFINKRIVERVRVRQILAVLNRRFVAYKGKMRIMDITQSLKMGTKLAAPTV
What is the function of this protein?
The VP3 protein is one of the five proteins (with VP1, VP4, VP6 and VP7) which form the inner capsid of the virus.
What are the official names of this protein?
Core protein VP3, Major inner capsid protein.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP3 family.
What are the subcellular locations of this protein?
Virion.
Protein: LEU1_BURP0
Sequence: MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKQLERMKVDVIEAGFAASSNGDFDAIQTIASQVKDSTICSLARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNIEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDLGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFARFKDLADRKAEIFDEDIIAIVTEEESALAQEHEHYKFVSLAQRSETGERPQAKVVFAVDGDEVAGEASGNGPVDATFNAIETEVGSGAELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYIAALNKLYSNADKLNPQRA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: AZOR_COPPD
Sequence: MAKVLYVKANPKNNEESRTFRISEHFINEYKKAHPEDEIIELDLYKENIHFLSKEEINTIMSKDKSNLKDHPVLKYTYQFAEADKYVIATPMWNLSIPAILKAYFDYITVTGITFKYTENGAVGLLKNKKAVVIMSTGGEYLTPPFDQWNFASTYVTTMFKFFGVEDVSLIAAQRLDIIGEDVEKRVSDAMKEAEQLAKQF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: PSBE_MARPO
Sequence: MSGNTGERPFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTENRQEVPLITGRFNSLEQIDEFTKSF
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PDCL3_MOUSE
Sequence: MQDPNADTEWNDILRKKGILPPKESLKELEEEEAEKEEQLLQQSVVKTYEDMTLEELEENEDEFSEEDERAIEMYRQQRLAEWKATQLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCSLINHHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTVFVYREGDIKAQFIGPLVFGGMNLTIDELEWKLSESGAIKTALEENPKKPIQDLLLSSVRGPVPMRRDSDSEDD
What is the function of this protein?
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:26059764).  Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity).  Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity).  Modulates the activation of caspases during apoptosis (By similarity).
What are the official names of this protein?
Phosducin-like protein 3, Viral IAP-associated factor 1, VIAF-1.
What is the protein family that this protein belongs to?
Belongs to the phosducin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
Protein: HSP70_LUPPO
Sequence: KVQDLLLLDVTPLSLGLETAGGVMTVLIPRNTTIPTKKEQVFSTYSDKEPGVLIQVFEGERTRTRDNNLLGKFELSGIPPAPRDVPQITVCFDIDANWCLNVSAEDKTTGQKNKITITNDKGRLSKEDIEKMVQEVEKYKAEDEEVKKKVDTKNALENYAYSMRNTITDDKITSKLPTEDKKKIEDTVDGAISRLDGNQLPEVEEFEDKMKELESLCNPIIAKMYQGVLAQMVLVLLIMADAPTGSGGAGPKIGEVD
What are the official names of this protein?
Heat shock 70 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PAAS_ARATH
Sequence: MENGSGKVLKPMDSEQLREYGHLMVDFIADYYKTIEDFPVLSQVQPGYLHKLLPDSAPDHPETLDQVLDDVRAKILPGVTHWQSPSFFAYYPSNSSVAGFLGEMLSAGLGIVGFSWVTSPAATELEMIVLDWVAKLLNLPEQFMSKGNGGGVIQGSASEAVLVVLIAARDKVLRSVGKNALEKLVVYSSDQTHSALQKACQIAGIHPENCRVLTTDSSTNYALRPESLQEAVSRDLEAGLIPFFLCANVGTTSSTAVDPLAALGKIANSNGIWFHVDAAYAGSACICPEYRQYIDGVETADSFNMNAHKWFLTNFDCSLLWVKDQDSLTLALSTNPEFLKNKASQANLVVDYKDWQIPLGRRFRSLKLWMVLRLYGSETLKSYIRNHIKLAKEFEQLVSQDPNFEIVTPRIFALVCFRLVPVKDEEKKCNNRNRELLDAVNSSGKLFMSHTALSGKIVLRCAIGAPLTEEKHVKEAWKIIQEEASYLLHK
What is the function of this protein?
Bifunctional enzyme that catalyzes the decarboxylation of L-phenylalanine to 2-phenylethylamine, which is then oxidized to form 2-phenylacetaldehyde, a constituent of floral scent (PubMed:21284755, PubMed:23204519).  2-phenylacetaldehyde is a precursor of 2-phenylethanol, another constituent of floral scent (PubMed:21284755).  Catalyzes both the decarboxylation and deamination of L-dopa to 3,4-dihydroxylphenylacetaldehyde (DHPAA) (PubMed:21284755).
What are the official names of this protein?
Phenylacetaldehyde synthase, AtPAAS, 3,4-dihydroxyphenylacetaldehyde synthase, DHPAA synthase, Aromatic L-amino acid decarboxylase, Aromatic aldehyde synthase, AtAAS.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: DAPA_SORC5
Sequence: MSQLPLSGTFTALVTPFTPDGEAVDFDALDALVEAQIAGGVSGLVPCGTTGESPTLSEAETTAVIRRVVEAARGRVPVIAGTGSFSTKKTIEASRAALAAGAAGVMIVMPYYSKPSQDGLREHTLAVARAVPAPIVLYNIPGRTVVDLSAETTERICAAAPNVVAIKDASGNVFRCQELVRRLGDRLTILSGDDALTLAMMALGAQGVISVTSNVLPRETSAVTRRFLAGDLAGARAAHLALLELHGLLFVEPNPAPAKAALAALGRMSAAVRLPLVPAGEATRQQIAEAMRRLEARREAS
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXT6_YEAST
Sequence: MSQDAAIAEQTPVEHLSAVDSASHSVLSTPSNKAERDEIKAYGEGEEHEPVVEIPKRPASAYVTVSIMCIMIAFGGFVFGWDTGTISGFINQTDFIRRFGMKHKDGTNYLSKVRTGLIVSIFNIGCAIGGIILSKLGDMYGRKVGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHLRGTLVSCYQLMITAGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGGMTFVPESPRYLAEVGKIEEAKRSIAVSNKVAVDDPSVLAEVEAVLAGVEAEKLAGNASWGELFSSKTKVLQRLIMGAMIQSLQQLTGDNYFFYYGTTIFKAVGLSDSFETSIVLGIVNFASTFVGIYVVERYGRRTCLLWGAASMTACMVVYASVGVTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFATTWAPIPYVVVSETFPLRVKSKAMSIATAANWLWGFLIGFFTPFITGAINFYYGYVFMGCLVFMFFYVLLVVPETKGLTLEEVNTMWEEGVLPWKSASWVPPSRRGANYDAEEMAHDDKPLYKRMFSTK
What is the function of this protein?
High-affinity glucose transporter.
What are the official names of this protein?
High-affinity hexose transporter HXT6.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YBEY_LISMF
Sequence: MTVLEIDLLDETKNLLDEDKQLVENILQFAAEYLKIEQGTELSLTFTTNEGIREINREYRDKDQATDVISFALEEMGDGETEIDWGEFDLETPRMLGDIIISTEKAEEQAKDYGHTKARELGFLAVHGLLHLLGYDHMEPDEEKIMFGLQKEVLDAYGLER
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR2_ECOLI
Sequence: MKVLVIGNGGREHALAWKAAQSPLVETVFVAPGNAGTALEPALQNVAIGVTDIPALLDFAQNEKIDLTIVGPEAPLVKGVVDTFRAAGLKIFGPTAGAAQLEGSKAFTKDFLARHKIPTAEYQNFTEVEPALAYLREKGAPIVIKADGLAAGKGVIVAMTLEEAEAAVHDMLAGNAFGDAGHRIVIEEFLDGEEASFIVMVDGEHVLPMATSQDHKRVGDKDTGPNTGGMGAYSPAPVVTDDVHQRTMERIIWPTVKGMAAEGNTYTGFLYAGLMIDKQGNPKVIEFNCRFGDPETQPIMLRMKSDLVELCLAACESKLDEKTSEWDERASLGVVMAAGGYPGDYRTGDVIHGLPLEEVAGGKVFHAGTKLADDEQVVTNGGRVLCVTALGHTVAEAQKRAYALMTDIHWDDCFCRKDIGWRAIEREQN
What is the function of this protein?
Catalyzes the reversible conversion of phosphoribosylamine to glycinamide ribonucleotide, an enzymatic step in purine biosynthesis pathway.
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: KBAY_ECOHS
Sequence: MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires KbaZ subunit for full activity and stability.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Ketose 1,6-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase KbaY subfamily.
Protein: RL3_MYCTA
Sequence: MARKGILGTKLGMTQVFDESNRVVPVTVVKAGPNVVTRIRTPERDGYSAVQLAYGEISPRKVNKPLTGQYTAAGVNPRRYLAELRLDDSDAATEYQVGQELTAEIFADGSYVDVTGTSKGKGFAGTMKRHGFRGQGASHGAQAVHRRPGSIGGCATPARVFKGTRMAGRMGNDRVTVLNLLVHKVDAENGVLLIKGAVPGRTGGLVMVRSAIKRGEK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: IAPP_RAT
Sequence: MRCISRLPAVLLILSVALGHLRATPVGSGTNPQVDKRKCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYGKRNVAEDPNRESLDFLLL
What is the function of this protein?
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
What are the official names of this protein?
Islet amyloid polypeptide, Amylin, Diabetes-associated peptide, DAP.
What is the protein family that this protein belongs to?
Belongs to the calcitonin family.
What are the subcellular locations of this protein?
Secreted.
Protein: BOT3_BOTFU
Sequence: MEKSNPTLDLATKTALLTWQKSNALLQHGIERATPFVLAVKSKAWQDAQSIGSKVAEAKFRDIDRTEITTITSVALGLYFAYVFCLVFYRLYLHPLAKFPGYRICAACEWYEFYCYIVKGGQWGNEIRKMHEKYGPIVRTSPWELSVRDPAFYDQLYVTASTRKTDMWPRGREGNGFDNSHHLSVSHELHRTRRKHLEPFFSRQGITRIESRIAERVMKMDDRLVGLKGSGSIIEVDHMLCALTGDIIGQVSSGMEAGLLDDPEFTPAWKDLMIKSTAIAPLFRCFPWINKFLQSLPTSIMNSVYPKGISNMMLGKTGQQNIEKIKTQIATSKRDLSDVSVFHHLLSSNVPESEKSIDRLRAESMILLLAGTLAGAHTLTFVVFYVLQNPQIEKRLRAELQPVFKGYPNKMPTWAELEKLPYLRGCVKEALRLNGLVGNLARCSPDEDIQFHQWVIPKKTPVGMSIYAMHFDQNVFSEPEAFKPERWIGEYNKQMDRNFVPFTKGSRSCLGVNLAWAELYLASAMLFRPGGPKLVLHDGGESDIKIARDYIMGFPKAGAKDVRVKIE
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of botrydial (PubMed:14651630, PubMed:19035644, PubMed:27529428).  Botrydial is necessary for colonization of plant tissue by the T4 strain (PubMed:19035644).  It is a strain-dependent virulence factor since highly aggressive strains like SAS56 or B05 still retain substantial virulence when botrydial synthesis is impaired, since they produce also botcinic acid (PubMed:15986930).  The first step of botrydial biosynthesis is performed by the sesquiterpene synthase BOT2 which catalyzes the cyclization of farnesyl diphosphate (FPP) to presilphiperfolan-8-beta-ol (PSP) (PubMed:19035644, PubMed:19476353).  The cytochrome P450 monooxygenase BOT4 then catalyzes the hydroxylation at C-4 to give a probotryane intermediate (PubMed:27529428, PubMed:28617493).  Acetylation of the hydroxyl at C-4 is carried out by the acetyltransferase BOT5, followed by the combined action of the P450 monooxygenases BOT3 and BOT1, to yield finally the glycol, via the regio- and stereospecific hydroxylations at C-10 and C-15 of the probotryane intermediates, respectively (PubMed:15986930, PubMed:27529428).  The cleavage of the C10-C15 bond of probotryane skeleton is an intriguing and chemically important reaction, which could be mediated by some of the monooxygenases or by a combination of them (PubMed:27529428).  It is possible that either BOT3 or BOT1 would oxidize either the 10- or the 15-hydroxy group to the hydroperoxide derivative, which would then undergo heterolytic fragmentation to give the dialdehyde botrydial (PubMed:27529428).  Finally, the dehydrogenase BOT7 might be involved in the conversion of botrydial to dihydrobotrydial (PubMed:27721016).
What are the official names of this protein?
Cytochrome P450 monooxygenase BOT3, Botrydial biosynthesis cluster protein 3, Calcineurin-dependent protein 11.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RSGA_THEVB
Sequence: MSHLVGLVRAVQANYYRVRLREPSNGVEELLCVRRARLKKMGQQVCVGDWVVVSHPDWPGQRGAIAEILPRRNQLSRPAIANVDQILLLFALADPPADVHPITRFLLTAEGLNVEIQVVFTKADLVSPQEQQQWRDRLQQWGYRCHVLSLTQGIAWQALRPHLANKITVVCGPSGVGKSSLIRHLTPREDIRVGAVSDHWHRGRHTTRHVELFPLAEGGWIADTPGFNQPELPPDPRQLAAAFPEIRQRLSQDQCLFDNCRHDQEPGCCVRGNWERYPLYIEYLHQLETIASAEPSLAKVPLVKAKSDRQGQQRLEPLLDAKKYRRRSRRQQHQHVNPMAEEVLDSEW
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_XANC8
Sequence: MTRSSSDRAIVVPAAQNALFTDSPFPTPESRLIAGVDEAGRGPLAGPVAVAAVVFDPAKPRINGLDDSKQLSAERREQLYARIVDRALAWSVVLIDSEEIDRINIYQATMLGMRRAVEGVAHVAGFARIDGNRVPKGLPCPAEALIGGDALDRAIMAASIVAKVTRDRLMRELHAQHPQYRFDLHKGYSTPAHLAALQTHGPCPQHRRSFAPVRRALGLETAQTAWDVPCAPADGLLLAE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBIA_MYCTU
Sequence: MKVTVLAGGVGGARFLLGVQQLLGLGQFAANSAHSDADHQLSAVVNVGDDAWIHGLRVCPDLDTCMYTLGGGVDPQRGWGQRDETWHAMQELVRYGVQPDWFELGDRDLATHLVRTQMLQAGYPLSQITEALCDRWQPGARLLPATDDRCETHVVITDPVDESRKAIHFQEWWVRYRAQVPTHSFAFVGAEKSSAATEAIAALADADIIMLAPSNPVVSIGAILAVPGIRAALREATAPIVGYSPIIGEKPLRGMADTCLSVIGVDSTAAAVGRHYGARCATGILDCWLVHDGDHAEIDGVTVRSVPLLMTDPNATAEMVRAGCDLAGVVA
What is the function of this protein?
Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
What are the official names of this protein?
Phosphoenolpyruvate transferase, EPPG:FO PEP transferase.
What is the protein family that this protein belongs to?
Belongs to the CofD family.
Protein: NDK_RICBR
Sequence: MTIQYTFSMIKPDAIKRNKIGQVNTYLENEGLKIVAQKMTTLTKYEAECFYDEHRARPFFDSLVEYITSGPVVLQVLKGMDAITLNRKVMGATNPAEAEAGTIRKDIGESIEANSIHGSDSENSAKREIKFFFKKSEIIE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_OCEIH
Sequence: MYYPEPITKLIDSFSKLPGIGPKTAARLAFFVLNMKEDDVLNFANALVSAKRELSHCSVCGHITDQDPCAICTDTSRDGSLICVVQDPKDVIAMEKMKEFHGKYHVLHGAISPMDGIGPEDINVPDLINRLKDEEVEELILATNPNIEGEATAMYISRLVKPSGIRTTRIAHGLPVGGDLEYADEVTLSKALEGRRDV
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: PFKA_ENTH1
Sequence: MSVKRRDHILIPKNPDAPLPSLKIEEVGECTIDNIYASPEPFVNGMTMKLSAVKNHGIERDSGEVELAGPMEKIFYNPETTKVAIVTCGGLCPGLNNVIRGLVLNLYNRYHVNNIFGLRWGYEGLVPELSEVQRLTPEIVSDIHQKGGSILGTSRGAQSPEVMAQFLIDNNFNILFTLGGDGTLRGANAINKELRRRKVPITVVGIPKTIDNDICYTDSTFGFQTAVGLSQEAINAVHSEAKSAKNGIGIVRLMGRDAGFIALYASLANGDANLVLIPEIDIPITQICEFVGKRIMSKGHVVIVVAEGALQNQKPKDLDLGTDKSGNILHWDSINYLRDSITKYLKSIGIEEHTIKFVDPSYMIRSAPCSAADAHFCMCLANAAVHVAMAGKTGLVICHHHNNFVSVPIDRTSYYIKRVNTDGPLYTMMTAIEKPK
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
Protein: RL20_PERMH
Sequence: MRVKGPSSKKHKKKILKLAKGYYGAKHRSFRRAKEQVLRSLQYEYRDRRLRKREFRRLWIQRINAAARLNGLSYSQFMHGLKLAGIDLNRKMLADIAVADPETFTKLAEKAKEAISQKSAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: GLPE_ECO24
Sequence: MDQFECINVADAHQKLQEKEAVLVDIRDPQSFAMGHAVQAFHLTNDTLGAFMRDNDFDTPVMVMCYHGNSSKGAAQYLLQQGYDVVYSIDGGFEAWQRQFPAEVAYGA
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_CYTH3
Sequence: MAKVKITQVVSAIKKTDNQKRVLASLGLGKINSSVEQELTPSIKGMLNKVNHLVVVSE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.