PharMolix/UniProtQA huggingface dataset:
Protein: C_SENDZ
Sequence: MASATLTAWIKMPSFLKKILKLRGRRQEDESRSRMLSDSSMLSCRVNQLTSEGTEAGSTTPSTLPKDQALLIEPKVRAKEKSQHRRPKIIDQVRRVESLGEQASQRQKHMLETLINKIYTGPLGEELVQTLYLRIWAMEETPESLKILQMREDIRDQVLKMKTERWLRTLIRGEKTKLKDFQKRYEEVHPYLMKEKVEQVIMEEAWSLAAHIVQE
What is the function of this protein?
The different isoforms prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways.  They inhibit IFN-alpha/beta induced tyrosine phosphorylation of STAT1 and STAT2.  Blocking the IFN-alpha/beta pathway requires binding to STAT1 in the cytoplasm.  They inhibit IFN-gamma induced serine phosphorylation of STAT1.  Block the IFN-gamma pathway by binding to and stabilizing the parallel form of the STAT1 dimer, further inducing high-molecular-weight complex (HMWC) formation and inhibition of transcription by IFN-gamma.  May also have a role in preventing the cell to enter apoptosis.  Modulate regulation of viral transcription and replication.  Overexpression inhibits the viral RNA polymerase.  The absence of all C', C, Y1 and Y2 proteins leads to viral delayed growth.  Plays an important role in virion particles release.  Modulates virion shape.
What are the official names of this protein?
C' protein.
What is the protein family that this protein belongs to?
Belongs to the respirovirus protein C family.
What are the subcellular locations of this protein?
[Isoform C' protein]: Host cytoplasm. Note=Protein C' seems to localize around the Golgi. SUBCELLULAR LOCATION: [Isoform C protein]: Host cytoplasm. Virion. Note=The C protein is found in virion at a ratio of approximately 40 molecules per virion, presumably associated with the nucleocapsid.
Protein: PSBD_ARATH
Sequence: MTIALGKFTKDEKDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWAFVALHGAFALIGFMLRQFELARSVQLRPYNAIAFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: UBIA_YERP3
Sequence: MKGSTVHTKWQAYCRLMRIDKPIGSLLLLWPTLWALWLAGRGIPEAKILVVFVLGVFFMRAAGCVVNDYADRHIDGFVKRTASRPLPSGTISEKESKILFVVLILLSFGLVLTLNSMTIWLSLAALALAWIYPFMKRVTHLPQVVLGAAFGWSIPMGFAAVSESLPLVCWLLLLANICWTVAYDTQYAMVDRDDDLRIGVKSTAILFGQHDKLIIGLLQLATLLLMVAIGWLMNLGGAFYWSILLAGALFTHQQKMIAQREREPCFRAFLNNNYVGLILFLGILISYW
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MAK5_ASPTN
Sequence: MGQKRQRDQKGSGFQSKKRKRGANSSNADDKDDGWDGIVGVEDLNWKEVALPDRLDDAEGFFGLEEIEGVDIVRPEGSGEIRFKAKAGKPKKSILKNKTIPQEDKTFDDEWEGFSDGEAAQETTTTEPTEEPVQTTNEETEVKEKKEPKKKEAKKEVKKDAKNAKKEPKKKDLPSQKDKDIKPGLSFAALQDAEEDDGVDISAWESLGLSPEILNSLSKLKFSSPTAVQKSCIPPILDGHDVVGKASTGSGKTLAFGIPILEYYLEKKRRETKNKDDKKETSPIALILSPTRELAHQLVKHIGEVITHAPGVNARIALLTGGLSVQKQQRLLNGADIVIGTPGRVWEVLSGGQGLISKMKEIKYLVVDEADRLLSEGHFKEAHEILAALDREEINDFPGAEEDESDDEDSKTQRQTLVFSATFHRDLQQKLAGKGKWTGSDLMNKQESMEYLLKKLNFREEKPKFIDVNPVSQMAEGLKEGIVECAAMEKDLYLYTLLLYHPKHRTLVFTNSISAVRRLTQFLQALQLPALALHSSMAQKARLRSVERFSSPTADPSTILVATDVAARGLDIKGIDFVIHYHAPRTADTYVHRSGRTARAGASGKSVIICAPEEMVGVVRLAAKVHANMANGKRLPLESLELDRRIVSRVKQRVTLAARICDANIAKEKVSAEDNWLKNAAEELGVDYDSEEFDERQGRGRGRGRGRQQRERQASSISKAELAGMRAELKQLLSQRVNVGVSERYLTSGRVDIEALLRGEGNASFLGQVDPLGF
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase mak5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ZEP1_ORYSJ
Sequence: MQKLGLSGLRGLEGFRSLAGSTSTAAKAPNPKPSSDIGGSTYGSFANLKITAEKLVKEQASVKTDLEMTHTKLRRATEQINLLEAKLQQAVNENAKLKVKQTEDSKLWQGLDSKVSSTKTLCNQLTETLQQLASQTERAEEDKKFFEEILGKNSKAFEEFNCLLHDSSIKLECAEQMIISGKQEMLRIKQEKEEMDQSYKEQLYASDTTIREKNSLIKQLEDSIEQNKARLLYVDSRLECMEQELKLKEDVCICLKENLASTESEKNDLKLRNEGYTLEVQKLSKDNKELNELLSGFTVKVTELDKEHTSISSHVTQLISSFERYDGKVHEEKMLMIKSAKDKFEHLQNQYVNLISENNALQTEIEELKSRIIELQKTQEIVMVQHVEECQVAEDKIRRLESEAEISASNISQLEKVASDLEGRVQKLLEDSRSAENHKQELLQKILKLESDNQELLGRVQSVLNEKSNDTESLQGEIAKRDQQVETLENQVNQLCSIIDEKEQLHTCAVEREKNLEEQKLQVQASLAATESQLTEAKKQYDIMLEGKKIELSKHLKELSLKNDQAINEIRRKYELEKVEIINIEKEKAEKLIKEMENKCNEKISENRQDSERYLMCLKEEHGSMVARIQQDNEHKESTLRAYHKEELQRIQSQAENELRERLSSLRKDHEIQMKSLTKKHEENCQKLQDELELQKSKEEKQRALLQLQWKVMGETQQVDQEVNSKKEYSVSSIKRRDPYIRKEHQLQLVSPETKRKDVNLSGIIQSPITNMLRKVEKGTQDIPKHRKVTHHEYEVETANGRITKRRKTKSTVMFGEPNTQKSLHDTADKDPTKMKKVVAGSHPHPANIGELFSEGSLNPYAEDPYAFG
What is the function of this protein?
Required for chromosome synapsis and regulates crossover frequency during meiosis.  Acts as transverse filament protein and constitutes the central element of the synaptonemal complex.
What are the official names of this protein?
Synaptonemal complex protein ZEP1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=During zygotene in meiocytes, initially localizes onto the chromosomes as punctate foci and quickly extends into linear signals (PubMed:20154151, PubMed:22393242). Associates with chromosomal axes at zygotene (PubMed:27436711).
Protein: RLMN_CERS1
Sequence: MTANAPITQDVMTLPRKLPEGGPVNIVGLTREELLAALVAAGTPERQAKMRAGQVWQWVYHWGVRDFAQMTNLAKDYRALLAEHFAIVLPEVVTRQISADGTRKYLIRIAGGHEVETVYIPEEGRGTLCVSSQVGCTLTCSFCHTGTQKLVRNLTAAEIVGQLMLVRDDLGEWPERGAPKDETRLVSNLVLMGMGEPLYNFENVRNAMKVVMDGEGLSLSRRRITLSTSGVVPEIARTAEEIGCQLAISFHATTDEVRDILVPINKRWNIRTLLDSLRDYPRLSNSERITFEYVMLDGVNDTDADARRLVKLISGIPSKINLIPFNEWPGAPYRRSTPERIAAFADIIYKAGYASPIRTPRGEDIMAACGQLKSATERARKSRAQIAAETGL
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNPY4_HUMAN
Sequence: MGPVRLGILLFLFLAVHEAWAGMLKEEDDDTERLPSKCEVCKLLSTELQAELSRTGRSREVLELGQVLDTGKRKRHVPYSVSETRLEEALENLCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTYLKKQCETMLEEFEDIVGDWYFHHQEQPLQNFLCEGHVLPAAETACLQETWTGKEITDGEEKTEGEEEQEEEEEEEEEEGGDKMTKTGSHPKLDREDL
What is the function of this protein?
Plays a role in the regulation of the cell surface expression of TLR4.
What are the official names of this protein?
Protein canopy homolog 4.
What is the protein family that this protein belongs to?
Belongs to the canopy family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y5214_PSEA7
Sequence: MERFFENAMYASRWLLAPIYMGLSLALLALTIKFFQEIFHVIPNIFAMAEADLILVLLSLIDMALVGGLLVMVMISGYENFVSQLDIDEGKEKLNWLGKMDSGSLKNKVAASIVAISSIHLLRIFMDAKNVPDNKLMWYVIIHMTFVLSAFAMGYLDKQTRH
What are the official names of this protein?
UPF0114 protein PSPA7_5214.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NODC_RHILV
Sequence: MTLLATTSIAAISLYAMLSTVYKSAQVFHARRTTISTTPAKDIETNPVPSVDVIVPCFNEDPIVLSECLASLAEQDYAGKLRIYVVDDGSKNRDAVVAQRAAYADDERFNFTILPKNVGKRKAIAAITQSSGDLILNVDSDTTIAPDVVSKLAHKMRDPAVGAAMGQMKASNQADTWLTRLIDMEYWLACNEERAAQARFGAVMCCCGPCAMYRRSAMLSLLDQYETQLYRGKPSDFGEDRHLTILMLSAGFRTEYVPSAIAATVVPDTMGVYLRQQLRWARSTFRDTLLALPVLPGLDRYLTLDAIGQNVGLLLLALSVLTGIGQFALTATLPWWTILVIGSMTLVRCSVAAYRARELRFLGFALHTLVNIFLLIPLKAYALCTLSNSDWLSRGSVAIAPTVGQQGATKMPGRATSEIAYSGE
What is the function of this protein?
Involved in the synthesis of Nod factor, a sulfated N-acyl-beta-1,4-tetrasaccharide of N-acetylglucosamine which initiates a series of events in the host plant species leading eventually to nodulation.
What are the official names of this protein?
N-acetylglucosaminyltransferase, Nodulation protein C.
What is the protein family that this protein belongs to?
Belongs to the NodC/HAS family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RUVA_MARMS
Sequence: MIGRIVGTLIEKTPPELMVDVNGIGYEVSASMTTIYDLPQIGGQVTLFTHLLVKEDSHTLYGFIDKNERALFRVLIKVNGIGPKMALAILSSMSSEELITNVQESDVTALTRIPGVGKKTAERLIIELRDKLGQAAKTDLFSAPAVLRQVQADPRQEAEAALISLGYKPQEAAKAIAGVPVDAANSEDVIKAALKGMLRK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: NQOR_RHOPS
Sequence: MAKVLVLYYSAYGHIEAMANAVAEGAREAGATVDIKRVPELVPPDVAKASHYKLDQAAPVATIGDLADYDAIVVGTGTRFGRMASQMANFLDQAGGLWAKGALHGKVGGAFTSTATQHGGQETTLFSIITNLLHFGMVVVGLNYGFAGQMKLDEVTGGAPYGATTITGGDGSRQPSANELAGARYQGKTIAETAIKLHG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: NDHK_SOYBN
Sequence: MNSIEFPLLDQTTKNSVISTTLNDLSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAIIDAITKLRKKISREIYENQMSSQRENRCFTTNHKFHIGYSTHTGNYGQELFYQLPSTSEIPSDTFF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: GUAA_MYCTO
Sequence: MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIVGEVTAKRVDTLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLERISTRITNEVAEVNRVVLDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: AHO3_CAEEL
Sequence: MSSGAPSGSSMSSTPGSPPPRAGGPNSVSFKDLCCLFCCPPFPSSIVSKLAFMPPEPSYTITEDNKLVLIEGRAAWPHQEVDMANCVEMRITRTRRRNRVACTMIRPLPNSHFTLLFSHGNAVDLGQMTSFLYGLGFHLNCNVFSYDYSGYGCSTGKPSEKNLYADITAAFELLKSEFGVPKEKIILYGQSIGTVPSVDLASREDLAALVLHSPLMSGMRVAFPGTTTTWCCDAFPSIEKVPRVKCPTLVIHGTDDEVIDFSHGVSIYERCPTSVEPLWVPGAGHNDVELHAAYLERLRSFIDMEASAIRVTAPITNATSTNSRTISNGTSS
What is the function of this protein?
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (By similarity).  Acts in sensory neurons including AWC to regulate starvation-induced thermotaxis plasticity and salt learning behavior.
What are the official names of this protein?
Alpha/beta hydrolase domain-containing protein aho-3, Abnormal hunger orientation protein 3.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. ABHD17 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Note=In neurons, localizes to the sensory endings and to cytoplasmic punctate structures.
Protein: ILVD1_RHILO
Sequence: MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLAGKTQALDLVDAMVAAADDKISDEDVKVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIVDLAQRYYEQDDETALPRSIASKGAFENAMTLDIAMGGSTNTVLHILAAAHEGEVDFTMEDIDRLSRRVPVLCKVAPAKSDVHMEDVHRAGGIMAILGQLDNAGLINRDLPTVHTSSLGEALDHWDISRTSSQNVRDFFLAAPGGVPTQVAFSQDRRWDELDLDREKGVIRSAETPFSKDGGLAVLKGNLALDGCIVKTAGVDESILKFTGPARVFESQDASVKAILSNEIKAGDVVVIRYEGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGTSGLSIGHASPEAAEGGTIGLVQEGDTIEIDIPNRTIRLAVSDAELDSRRAAMEAKGALAWKPEEKRKRKVTTALRAYAAFATSADKGAVRHVPE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase 1, DAD 1.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RF1_CAMJ8
Sequence: MLASKLDPFLKRFEELNSLLSSSDILNDISKMTTLSKEQKNLEPIVLKAKEYLKTLDNIEENKALLNDPELGELAKEELKTLEELKPKLEEEIKILLLPKDPNDERNIFLEIRAGTGGDEASLFVGDLVKAYARYAENRGYKLEIVSSSEGSVGGFKEIIMLVKGTGAYSRLKYEGGTHRVQRVPQTESQGRVHTSAITVAVMPEVDDIEIEINPNDLKVDVMRSSGHGGQSVNTTDSAVRITHIPTGIVVVNQDGKSQHKNKESAMKVLKARLYEMQESERLAKESEARKSQVGSGDRSERIRTYNFPQNRISDHRINLTLYRLDAIMQDGLFDEIIEPLITHHQAQALQEQNL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_MOOTA
Sequence: MNLETVAKVDPEIVAAVRGELQRQRTHLELIASENFVSQAVMEAYSCVLTNKYAEGYPGKRYYGGCEWADVVENLARERAKALFGAEHANVQPHSGSQANTAVYLAVLNPGDKALGMNLAHGGHLTHGSPVSLSGKYYNFCFYGVDAKTGRIDYDAVARIAREERPRLIVAGASAYPRVIDFARFREIADEVGALLMVDMAHIAGLVAAGIHPNPVPYAHFVTTTTHKTMRGPRGGIILTTREYARDIDKAVFPGVQGGPLMHVIAAKAVALKEAMLPEFKRYQEQIVTNARTLADALMGYGFNLVSGGTDNHLMLVDLRNKNITGREAEDILASVQITVNKNAIPFDPQKPSVTSGIRLGTAALTSRGMDADAMVQVARAIDLALSYGPDEKKLEEARGIVAELCRAFPLYQELD
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_LEPBJ
Sequence: MQDPEKFSIESIKERLKERFPKEMDEIIYFFDLELICKFTLFLKEKNEVGGFFSKRDSMEILDRHVLESIYHVYRITKKIGSWKGIQLGDAGTGPGIPGFFFRCLKAYPVVVLIDSQKRKLSHTESFVRSNRITDLKFQFIRTEESKLSLNYVVSRGFIPYPYSVEAVSNLIKIGGTYVPFLGKHDIDVKLEEKVLSYSGFRLESSEDLSSLEFLGMRHIKFLKKISSPRHGYPRTWKDISKESKSGNGKDRID
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADEC_BRUME
Sequence: MRHCDSFCELIPMKGCEAILEWMIDQGAGREPADIVLKGGRFLDLITGELVESDIAICEDRIVGTFGTYRGKHEIDVSGRIVVPGFIDTHLHIASSQVTPHEFDRCVLPQGVTTAICDPHEIANVLGAEGIRFFLDSALETVMDIRVQLSSCVPATHMETSGAELLIDDLLPFADHPKVIGLAEFMNFPGVLAKDPECMAKLRAFQGRHIDGHAPLLRGLDLNGYIAAGIRTEHEATNAEEALEKLRKGMYVLVREGSVSKDLKALMPIITERHAQFLALCTDDRNPLDIADQGHLDYLIRTAIAGGVEPLAIYRAASVSAARVFGLFDRGLVAPGQRADLVVVDSLEGCHAEIVLSAGRVVSEALFAARKPVAEVGRNSVKAPRVTASNFRSQSNSGKTRAIGIVPGKIITQNLEFDLKVGPNGVEPDLERDVVKVAVIERHGKNGNIATGFVHGFGLKAGAIASTVSHDSHNICVVGASDEDIATAANRLGEIEGGFVVVRDGKVLAEIPLPIAGLMSTEPYETVREALRKLRHAAEDLGSVLEEPFLQLAFIALPVIPHLKITDRGLVDVDKFEFVGN
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: PER_DROMO
Sequence: EGSGGSGSSGNFTTGSNVRMSSVTNTSNAGTGTSAGDNSAGGNGSGNSNSAPAVTVTLTESLLNK
What is the function of this protein?
Essential for biological clock functions.  Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms.  Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system.  The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex.  Light induces the degradation of TIM, which promotes elimination of PER.  Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop.  Behaves as a negative element in circadian transcriptional loop.  Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
What are the official names of this protein?
Period circadian protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization (By similarity).
Protein: CEFG_ACRCH
Sequence: MLPSAQVARLKPDPFPPSLSPIPHGAVTFAALAPCHNLPIFSSRQMLRDSLTYSHTSPTMSPQIANRFEASLDAQDIARISLFTLESGVILRDVPVAYKSWGRMNVSRDNCVIVCHTLTSSAHVTSWWPTLFGQGRAFDTSRYFIICLNYLGSPFGSAGPCSPDPDAEGQRPYGAKFPRTTIRDDVRIHRQVLDRLGVRQIAAVVGASMGGMHTLEWAFFGPEYVRKIVPIATSCRQSGWCAAWFETQRQCIYDDPKYLDGEYDVDDQPVRGLETARKIANLTYKSKPAMDERFHMAPGVQAGRNISSQDAKKEINGTDSGNSHRAGQPIEAVSSYLRYQAQKFAASFDANCYIAMTLKFDTHDISRGRAGSIPEALAMITQPALIICARSDGLYSFDEHVEMGRSIPNSRLCVVDTNEGHDFFVMEADKVNDAVRGFLDQSLM
What is the function of this protein?
Catalyzes the conversion of deacetylcephalosporin C to cephalosporin C.
What are the official names of this protein?
Acetyl-CoA--deacetylcephalosporin C acetyltransferase, DAC acetyltransferase, DAC-AT, DCPC-ATF.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
Protein: QUEC_GEODF
Sequence: MKKKAVILYSGGLDSTTCMAIAREEGFEPYAMSFDYGQRHSVELATAKANAKTMGASEHLVVSFDLRKVGGSALTADLDVPKEGIGAGIPVTYVPARNTIFLSFALGWAEVLGAFDIFIGVNALDYSGYPDCRPEYIAAFEATANLATRAGVEGTGRFVIHAPLIAMTKAEIIRKGLALGVDYGRTHSCYDPTPEGLACGLCDSCRLRLKGFAEAGVTDPVPYAVRSKK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RIMK_SALPA
Sequence: MKIAILSRDGTLYSCKRLREAAMRRGHLVEILDPLSCYMNINPAASSIHYKGRRLPHFDAVIPRIGSAITFYGTAALRQFELLGSYPLNESVAITRARDKLRSLQLLARQGIDLPITGIAHSPDDTSDLIKMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIAEAKGCDIRCLVVGNEVVAAIERCAKAGDFRSNLHRGGVASIATITPRERDIAIKAAQTLGLDVAGVDILRAARGPLVMEVNASPGLEGIEKTTGVDIAGRMIQWIERHATPEFCLKIGG
What is the function of this protein?
Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF).  Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate.  The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.
What are the official names of this protein?
Ribosomal protein S6--L-glutamate ligase, Poly-alpha-glutamate synthase, Ribosomal protein S6 modification protein.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: MNHG2_STAAM
Sequence: MEITKEIFSLIAAVMLLLGSFIALISAIGIVKFQDVFLRSHAATKSSTLSVLLTLIGVLIYFIVNTGFFSVRLLLSLVFINLTSPVGMHLVARAAYRNGAYMYRKNDAHTHASILLSSNEQNSTEALQLRAKKREEHRKKWYQND
What are the official names of this protein?
Putative antiporter subunit mnhG2, Mrp complex subunit G2, Putative NADH-ubiquinone oxidoreductase subunit mnhF2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.