PharMolix/UniProtQA huggingface dataset:
Protein: PYRH_MALP2
Sequence: MNKELVILKISGASLKGKNDIIDLDFLREIGRQIKVLSNNYKVAIVLGGGNIWRGNIAKEIGMQRYKADQMGMLATVMNSLALQSLLTNINVKSRIFSTIEMEKIADSYIIRNLEESLNNNEIAILSCGTGRPYFTTDTGVAVSAAELGASYIMMGKNNVDGVYDSDPNKNPNAKFYKHLTYSKAIELGLEVMDITAATICKQSNIKTIVFKMNEKNGILNAFENKSKFTLVSEDEKDLDAFKFGIKNIKNNSEKSSNNWDNKVIDIKTIKEENSLNIDDIFENSIEELQKLKEDDIQKNQKKLNEIIKSFYQDNKE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN574_XENTR
Sequence: MTDSEETVLYVEHRYVCSECGEEYPSLEEALEHQQSHAAALQEPQYQIVGVNSLENQYQCLECGLLLRTPEDLLAHQELHPTQNEIQKPKRPTRSEIHYECPECKALFNSQDVWMAHRYTHMQVQDVSHSKIVLQTDDHVIEDGLQLMCAPAVPSEVHLVTGDPHFHVSTPSSASVSHTQVLVDLEHSYKKNEGAGEDCAMELLLYKCSECTQLFQTPGEFLEHQGTHFSGQERISDTNSHLDQTPQLSLNGQEKEPIINQGNTCTDYQAENKELLVQPEGEQAEQDSWTVDREPVFSCGDCSETFQTTKDLEEHQISHQNGPFSCPLCSKVFPTYPEVGEHLKSHRSESRYLCVDCGLAFVSEAVLLNHRRSHLANPLFTCECGLTFLNMTRFLYHRRVHSSKQPDTGAVEEKKTVNSIAPSPAGNFHCDPCGKDFPLLSQFLRHQRFVHALERRHKCPTCGKHFKKGSHLRTHMLTHTGERPYSCTVCSKSFNSQANLLRHRLTHTGEKPYKCQLCGKAFSQSSTLQQHQYVHGQAYLYKCNECGINFHRPYRLLLHQYHHTGEYPYKCQDCGLSFLLKRLLEVHQLGHRGEEPHRCRECGTNFPSVQRLQDHRCSKAGDGGGEKLECPICGKKVTSDAHLNTHVAAQHSGNKRSNVSSGKGTPVLPRNKLKGGGGKNLECSDCHKTFSTETSLQVHRRIHTGERPYPCPDCGKAFRQSTHLKDHRRLHTGEKPFKCDVCGKAFTIAVRLSEHKRIHTGERPHSCPDCGRAYRSFSNLWKHRKLHREQQVQLQEPESQPADLSSTVAILETVETIPIIETVEIFPEGSTISVQDIQFETLQVENIHLGNIQIGTL
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 574.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PURA_PLAYO
Sequence: MNIFEHSIKNVDKGNVVAIVGTQWGDEGKGKIIDILSKYSDITCRFNGGGNAGHTICVGNKKHALHLLPCGVLYENNINILGNCMVIHLKTLMKEINNLGNNILDRIYISEKAHILFDIHQEIDAIQETRKSKDGNAIGTTKKGIGPCYSTKASRIGIRMGSLRNFENFKKLYIKLIDNLMDLYNIKDYNKEEELNEFYTYHKILKDKIINIISYINKSIDSKKYILIEGANAAMLDIDLGTYPFVTSSSTTLGGIFSGLGIHHKKLNLVVGVVKSYLTRVGSGPFLTEQCNEIGEYLTKKGFEYGTTTNRPRRCGWLDLPMLFYVKYINCIDIINLTKLDVLSGLKEIYVCVDYKNKTTGELLERGSYPLEDEQLREYEPVYEKFEGWDEDITNCIEFDELPENAKKYVLTIESYIKTPIVWVGVGPTRDNTITRKFD
What is the function of this protein?
Plays an important role in the salvage pathway for purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IXTPA_STRPQ
Sequence: MSEKIYEYKDENNWFIGKMTGHNLISGWGVKHTTIKKIDDLLDGIAATLDWENPKGYDVSVVRYQSPLSLITFIIDMINQETQREIKVTPHAGTILLIENAKLLAVYLPEGGVSTATFFATSEQGFGDIILIATRNEGKTKEFRNLFGQLGYRVENLNDYPELPEVAETGTTFEENARLKAETISRLTGKMVLADDSGLKVDALGGLPGVWSARFSGPDATDAKNNTKLLHELAMVFDQKKRSAQFHTTLVVAAPNKDSLVMEAEWPGYIATQPKGENGFGYDPVFIVGETGRHAAELEADQKNQLSHRGQAVRKLMEVFPAWQAKQS
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: METK_GEOKA
Sequence: MSAKRRLFTSESVTEGHPDKICDQISDAILDAILEKDPNARVACETSVTTGLVLVSGEITTSTYVDIPRIVRDTVREIGYTRAKYGFDADTCAVLTSIDEQSPDIAMGVDRALEAREGQMTDEEIEAIGAGDQGLMFGFACNETEELMPMPISLAHRLARRLAEVRKTDVLPYLRPDGKTQVTIEYDENGKPVRVDTIVVSAQHHPEITQEQIQRDIKEQVIKPVVPAELLDENTKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAGLADKCEVQLAYAIGVARPVSISIDTFGTGKVSEDILIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDIDLPWERTDKAALLKEQALALADK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS82_BACC1
Sequence: MQVKDQLSSLQPYKPGKSPEQMKEVYGDHAFVKLASNENPFGCSPRVLDELQKSWLDHALYPDGGATTLRQTIANKLQVQMEQVLCGSGLDEVIQIISRAALKAGDNIVTAGATFPQYRHHAIIEGCEVKEVPLNNGVYDLDEISSAVNNNTKIVWICNPNNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAIGQEELIEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLQQYESFCKENDIPFYPSQTNFIFLPVENAGEIYEACAHAGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKSRDEANA
What are the official names of this protein?
Histidinol-phosphate aminotransferase 2, Imidazole acetol-phosphate transaminase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: BIOB_BORPD
Sequence: MHISTIPVSDIAKPNAPAAGAWQADDVLALYELPFMDLLYRAQQVHRQHFDASAIQLSSLLSIKTGGCPEDCAYCPQSAHYDTGLAADKLMPLEDVLQAARAAQAGGAQRFCMGAAWRSPKPHHLDEVAEMIRAVKALGLETCVTLGMLRDGQAEQLKEAGLDYYNHNLDTSPEFYGSIISTRTYQDRLDTLARVRDAGLNVCCGGIVGMGESRRERAGLIAQLASLDPYPESVPINNLVQVEGTPLAGTEALDPFEFVRTIAVARIVMPLARVRLSAGRETMSDTLQALCFLAGANSLFCGDVLLTTGNPQVEADQRLLERLGMHAEGALPALPQATPA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: PPNP_PECAS
Sequence: MLNVNEYFAGKVKSIGFEGDSIGRASVGVMDAGEYTFGTGQPEEMTVITGALKVLLPGAPDWQVFTPGETFFVPGKSEFNLQVVEPTSYLCKYL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: RL35_PLAFE
Sequence: MAKIKARDLRGKKKEELLKQLDDLKNEPSQLRVAKVTGGAASKLTKICVVRKSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPRKTRALRRRLNKHEESLRTKKQQRKDLLYSIRKFAVKA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_MYCSJ
Sequence: MGESQPVKTFDALFDELTERARTRPEGSGTVAALDGGVHGLGKKILEEAGEVWLAAEHESDEALAEEISQLLYWTQVLMIARGLSPDDVYRKL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEZ6_HUMAN
Sequence: MRPVALLLLPSLLALLAHGLSLEAPTVGKGQAPGIEETDGELTAAPTPEQPERGVHFVTTAPTLKLLNHHPLLEEFLQEGLEKGDEELRPALPFQPDPPAPFTPSPLPRLANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGPGEIASTTPPSRAWTPTQEGPGDMGRPWVAEVVSQGAGIGIQGTITSSTASGDDEETTTTTTIITTTITTVQTPGPCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRLQGKSSLQLPRPRPRPYNRITIESAFDNPTYETGSLSFAGDERI
What is the function of this protein?
May play a role in cell-cell recognition and in neuronal membrane signaling.  Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor.  Involved in the development of appropriate excitatory synaptic connectivity (By similarity).
What are the official names of this protein?
Seizure protein 6 homolog, SEZ-6, hSEZ-6.
What is the protein family that this protein belongs to?
Belongs to the SEZ6 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Localized on dendrites and in the synaptic and postsynaptic fraction.
Protein: NIKR_ECOSE
Sequence: MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRSALAQEATQQHGTQGFAVLSYVYEHEKRDLASRIVSTQHHHHELSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRGVRHGHLQCLPKED
What is the function of this protein?
Transcriptional repressor of the nikABCDE operon.  Is active in the presence of excessive concentrations of intracellular nickel.
What are the official names of this protein?
Nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: OTU6A_MOUSE
Sequence: MSDTEQELQRVIRRHYREKRELQAHIQTLKASVPKNDKGRRKQMLADISRLEAEMEQRHKQELEKFGENPDSSVDSVTADLEKMNLENMPPRPPKAQKRRDRRAHQERRHQERMPAAQAEQLAANRREEEEKVAAILGAKNLEMKTIPADGHCMYRAIQDQLVFSVTIESLRYRTAYYMRKHIDDFLPFFTEPEAGNFYTREDFLRYCDDIVHNASWGGQLELRALSHVLQTPIEVVQANSPTIVIGEEYTRKPVTLVYLHYACDFGEHYNSVKPIEVAGAFGGMAPRLF
What is the function of this protein?
Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains.  Also able to hydrolyze 'Lys-11'-linked ubiquitin chains (By similarity).
What are the official names of this protein?
OTU domain-containing protein 6A, Hin-6 protease.
Protein: MA1A1_RABIT
Sequence: REPADAAVREKRAKIKEMMEHAWNSYKRYAWGLNELKPITKEGHSSSLFGTIKGATIVDALDTLFIMGMESEFQEAKSWIAENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGIKLLPAFHTPSGIPWALLNIKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAEKVMNIRKVLNKLEKPEGLYPNYLNPSSGQWGQHHVSIGGLGDSFYEYLLKAWLMSEKTDLEAKKMYFDAVQAIETHLIRKSSGGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADGAPEGRAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQNEKYYILRPEVVETYMYMWRLTHDPKYRKWAWEAVEALESHCRVNGGYSGLRDVYFTHEKYDNVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNTEAHLLPILPTDQKEVEVKVK
What is the function of this protein?
Involved in the maturation of Asn-linked oligosaccharides.  Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
What are the official names of this protein?
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, Man(9)-alpha-mannosidase, Mannosidase alpha class 1A member 1, Processing alpha-1,2-mannosidase IA, Alpha-1,2-mannosidase IA.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: BGAL_SHISS
Sequence: MIMITDSLAVVLQRRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWRFAWFPAPEAVPESWLECDLPEADTVVVPSNWQMHGYDAPIYTNVTYPITVNPPFVPAENPTGCYSLTFNIDESWLQEGQTRIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFDLSAFLRAGKNRLAVMVLRWSDGSYLEDQDMWRMSGIFRDVSLLHKPSTQISDFHVATHFNDDFSRAVLEAEVQMYGELRDELRVTVSLWQGETQVASGTAPFGGEIIDERGGYADRVTLRLNVENPALWSAEIPNLYRAVVELHTDDGTLIEAEACDVGFREVRIENGLLLLNGKPLLIRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRFGLYVVDEANIETHGMVPMNRLTDDPRWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPMYARVDEDQPFPAVPKWSIKKWLSLPGETRPLILCEYAHAMGNSLGGFAKYWQAFRQYPRLQGGFVWDWVDQSLIKYDENGNPWSAYGGDFGDTPNDRQFCMNGLVFADRTPHPALTEAKHQQQFFQFRLSGQTIEVTSEYLFRHSDNELLHWSVALDGKPLASGEMPLDVAPQDKQLIELPELPQPESAGQLWLTVHVVQPNATAWSEAGHISAWQQWRLAENLSVTLPAAPHAIPQLTTSETDFCIELGNKRWQFNRQSGFLSQMWIGAEKQLLTPLRDQFTRAPLDNDIGVSEATRIDPNAWVERWKAAGHYQAEAALLQCTADTLADAVLITTAHAWQHQGKTLFISRKTYRIDGSGQMAITVDVEVASDTPHPARIGLTCQLAQVAERVNWLGLGPQENYPDRLTAACFDRWDLPLSDMYTPYVFPSENGLRCGTRELNYGPHQWRGDFQFNISRYSQQQLMETSHRHLLHAEEGTWLNIDGFHMGIGGDDSWSPSVSAEFQLSAGSYHYQLVWCQK
What are the official names of this protein?
Beta-galactosidase, Beta-gal, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: EAT20_CAEBR
Sequence: MTTFCRVLLIFGIYVAVSCAQSVEDDVFHFTNPSQGNAVWILDESSLPWTGGYQFLRSISGMPTTLLSIVDSSTGVTLGQCVAPQDATGNFSKRWEKFSWELTASGLDCQFEQGAATRVEFDRSQNPRTFSIRIQSITGPACLRDVVVQTEQATGCPPHLSRNSFTANALNCSCPYLDAANEDGETENEDVDMLANSPQFPLFKVVDPSVLGSANPPTLPPSPCANHECHNNGTCLVSQEGAAMCLCRNGFTGDRCELDVCSAVPCQNGGVCRSNNGIAYCECPPAFSGLLCESAHTDESAAPICNPECSNGQCVLKDGQPQCECRQGFTGANCNVLDVCLGDAACSMFGPSAKCVLDDNMDKMSSASLINGTYDCLCPHPIHGQFVDCMQLHAPSATSVQPSEPAVVINNVTPSFPVLEISQVPTGAPKTFTATSTTSVATQPAVPVVQTLPTTQQVPSEPFVGFTVTREPLRPFEATTTTTLPPPFQQHIITAGEQPTWSSQQPQQPSEVPVPAQTMTTFIFPQTPETTTFPPTTGATVHKFVSPNMPDENEEEEEDETTDETEETFPTPSTMQVATDSSIRSEFFTSTFPTTTDMEETDEEEDMTEEVTDSSTQPSTTVFIQPSSTTFTTEAPTTTMEEEETTEQEEIESEEAISTTTQTSLPFWMTTIAIKMPDIVASPTPMIIMPHPQPEEKMETSTEGIESEEERTTESNEEIIPKNMEPTTPSDITHHHTSSGKQSSAVASWIIATIALIVLGSLLLATSLFVLRYIRQSRKLHGKYNPAREEHNLSAAYAMPMSHIAKEERLI
What is the function of this protein?
Regulates pharyngeal pumping during feeding.
What are the official names of this protein?
Abnormal pharyngeal pumping eat-20.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SPRN_GASAC
Sequence: MSGMNQVVATCWTCLLLSAFLCEPVLSKGGRGGSRGSSRGSHSRSPKAGGYRGGGPHNGGTRGSRYRGRSSPVRVASAAAAGAAVALTADKWYASAYRRSKADGSDEELDYYNRTNYFDAQMSSSTQNGSSLSQLVSIIIATFSPKYGLLMDSIL
What is the function of this protein?
Prion-like protein that has PrP(C)-like neuroprotective activity.
What are the official names of this protein?
Shadow of prion protein, Protein shadoo.
What is the protein family that this protein belongs to?
Belongs to the SPRN family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: RARA_NOTVI
Sequence: MASNGGSCPSSGGHMNGYPVPHYAFFFPHMLGGLSPPGSLAGIPHPLPVSAYSTPSPATIETQSTSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKTCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKQEAPKQECTESYIITPEVEDLVEKVRKAHQETFPALCQLGKYTTNNSSEERVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPDQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDKVDKLQEPLLEALKIYVRKRRPNKPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDSLTGQPPRASSLAPPPGSCSPSLSPSSNRSSPTSHSP
What is the function of this protein?
Receptor for retinoic acid.  Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.  The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity).  Retinoic acid signaling appears to be involved in specifying proximal-distal axis in limb regeneration.
What are the official names of this protein?
Retinoic acid receptor alpha, RAR-alpha, Nuclear receptor subfamily 1 group B member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TAT_SIVMK
Sequence: METPLREQENSLESSNERSSCILEADATTPESANLGEEILSQLYRPLEACYNTCYCKKCCYHCQFCFLKKGLGICYEQSRKRRRTPKKAKANTSSASNNRLIPNRTRHCQPEKAKKETVEKAVATAPGLGR
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors.  Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.  Through (By similarity).
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus.
Protein: YOR8_TTV1K
Sequence: MLHHIPLFLSSTASPFFIRLIRFLTYSVIFTRSSSSICIVVLMPLLMYIRCPLSAPASAIYTFNCHLLSACQSRLKFVLISTMRPHHI
What are the official names of this protein?
Uncharacterized 10.0 kDa protein.
Protein: MYO12_ARATH
Sequence: MGTPVNITLGSHVWVEDPELAWISGEVTEIKGTNAKIVTANGKTVVASISSIYPKDTEAPPAGVDDMTKLAYLHEPGVLHNLDCRFALNEIYTYTGNILIAVNPFQRLPHLYSVHMMEQYKGAAFGELSPHLFAVADTSYRAMINEARSQSILVSGESGAGKTETTKMLMRYLAFMGGRSDTEGRSVEQQVLESNPVLEAFGNAKTVKNNNSSRFGKFVEIQFDKRGKISGAAIRTYLLERSRVCQVSDPERNYHCFYMLCAAPPEEAKKFKVGDPRTFHYLNQTNCYEVSNVDDAREYLETRNAMDIVGIGQEAQDAIFRVVAAILHLGNVNFIKGEEADSSKLRDDKSRYHLQTAAELLMCNEKMMEDSLCKRVIVTPDGNITKPLDPESAASNRDALAKTVYSRLFDWIVDKINSSIGQDPDAKSLIGVLDIYGFESFKINSFEQLCINLTNEKLQQHFNQHVFKMEQEEYTREEINWSYVEFVDNQDVLDLIEKKPGGIIALLDEACMFPKSTHETFAQKMYQTYKGHKRFSKPKLAQTAFTVNHYAGDVTYSAEQFLDKNKDYVVAEHQALLDASKCSFVANLFPPLPEDASKQSKFSSIGTRFKQQLQALMETLNTTEPHYIRCVKPNAVLKPGIFENDNVLNQLRCGGVLEAIRISCAGYPTKRAFDEFLDRFVMLATDVPEGSDEKSACASICNKMGLKGYQIGKTKIFLRAGQMAELDARRTEVLAGATKLIQRQIRTYLTRKEFLGQKRATIYMQKLWRAKLARKLYQNMRREAASICIQKNIRAHRARKNYTKLQASATVIQTGLRTMSARNKHRHRRRTKAAIIIQREWRRHQVHEAYKKHKKATLALQCLWRAKVARKELKNLRMAARETGALKEAKDKLEKRVEELTWRLELEKNQKADLEDAKAQEIAKLQNNLTELQEKLDEAYAAIIRDKEAAKLAIEQAPPIIKEVPVVDNTQLELLNSQNNELEVEVAKLKGKIKEFEVKCFALENDSRASVTEAEDAKSKAVEFQEIIERLHTNLSNLESENQVLRQQALAASTSVEEIGELNSLKDKVAILESENETLRRQTESAEKTMPPARVFASEKNLENEHQTKEIQATKEPRNPINVLAKQGSLTDRQQESHEVLMKCLTDERRFDNEKSVAAWIVYKALLQWRLFEAEKTNIFDRIVHKIRSSIEGQDDTRELAYWLTTSSTLLYLLQSTLKFSNTNNAASRRNRSSHATLFGRLVQGMQPSSVGLETSSGYSGMAGIPNDQQMVEAKYPALLFKQHLAAYVEKTYGMIRDKLKKEINPLLNLCIHAPRPTRAKTLRDVTKSIHLTTIAKQQASYVQWQNIVNKLEHTLTFMAENHVPSMITRKLFHQVFSYINVQLFNSLLLRRECCSVSNGEYLKMGLHELEQWCLKADDEATRSPWDELQHIRQAVMFLVSHQKTQKSLDEIAKEICPVLSIPQVYRIGTMFWDDKYGTQGLSPEVINQMRKLMTEDSANMTYPSFLLDVDSSIPFSVEDVSQSFHGGNISLSDVDPSPLLRQRSDFHFLFQTLPE
What is the function of this protein?
Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation.  Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables (By similarity).
What are the official names of this protein?
Myosin-12, Myosin XI F, AtXIF.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Plant myosin class XI subfamily.
Protein: ESR1_FELCA
Sequence: MTMTLHTKASGMALLHQIQGNELETLNRPQLKIPLERPLGEVYVDGSKPAVYNYPEGAAYDFNAAAAASAPVYGQSGLAYGSGSEAAAFGANGLGGFPPLNSVSPSPLVLLHPPPQLSPFLHPHGQQVPYYLENEPSGYAVREAGPPAFYRPTSDNRRQSGRERLASTGDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDEGEGRNEVGSSGDVRASNLWPSPLLIKHTKKNSPALSLTADQMVSALLEAEPPIIYSDYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLSLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLSLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPANRGGAPMEEMNQSQLATTGSTSAHSLQAYYITEEAGAFPTTV
What is the function of this protein?
Nuclear hormone receptor.  The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.  Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling.  Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components.  Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner.  Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter.  Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP.  Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences.  Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP.  Can activate the transcriptional activity of TFF1.  Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
What are the official names of this protein?
Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
Protein: ATG13_HUMAN
Sequence: METDLNSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKKALAGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCDKEIKVSYTVYNRLSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGEVQLSGLGEGFQTVRVGTVGTPVGTITLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAGEDTGVIYPSVEDSQEVCTTSFSTSPPSQLSSSRLSYQPAALGVGSADLAYPVVFAAGLNATHPHQLMVPGKEGGVPLAPNQPVHGTQADQERLATCTPSDRTHCAATPSSSEDTETVSNSSEGRASPHDVLETIFVRKVGAFVNKPINQVTLTSLDIPFAMFAPKNLELEDTDPMVNPPDSPETESPLQGSLHSDGSSGGSSGNTHDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLSIDIGAQSMAEDLDSLPEKLAVHEKNVREFDAFVETLQ
What is the function of this protein?
Autophagy factor required for autophagosome formation and mitophagy.  Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.  Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
What are the official names of this protein?
Autophagy-related protein 13.
What is the protein family that this protein belongs to?
Belongs to the ATG13 family. Metazoan subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.