PharMolix/UniProtQA huggingface dataset:
Protein: CNMD_BOVIN
Sequence: MTENSDKVPIALVGPDDVEFCSPPAYAAVTVKPSSPARLLKVGAVVLISGAVLLLLGAIGAFYFWKGSDNHIYNVHYTMSINGKLQDGSMEIDAGNNLETFKMGSGAEEAVEVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVGTMTKQSISSELEGKIMPVKYEENSLIWVAGDQPVKDNSFLSSKVLELCGDLPIFWLKPTYPKEIQRERRELVRKIVTTTTTRRLRSGPQGTPAPGRPNNGTRPSVQEDAEPFNPDNPYHQQEGESMTFDPRLDHEGICCIECRRSYTHCQKICEPLGGYHPWPYNYQGCRSACRVIMPCSWWVARILGMV
What is the function of this protein?
Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells.  May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.  Inhibits in vitro tube formation and mobilization of endothelial cells.  Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity).
What are the official names of this protein?
Leukocyte cell-derived chemotaxin 1, Chondromodulin, Small cartilage-derived glycoprotein, SCGP.
What is the protein family that this protein belongs to?
Belongs to the chondromodulin-1 family.
What are the subcellular locations of this protein?
[Chondromodulin-1]: Secreted, extracellular space, extracellular matrix. Note=Accumulated in the inter-territorial matrix of cartilage. SUBCELLULAR LOCATION: [Chondrosurfactant protein]: Endomembrane system; Single-pass membrane protein.
Protein: PCDA6_HUMAN
Sequence: MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGAAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPPTEGACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEGPPKMDLMAFSPSLSPCPIMMGKAENQDLNEDHDAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin alpha-6, PCDH-alpha-6.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single- pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: RBL_MORIN
Sequence: MSPQTETKASVGFKAGVKDYKLTYYTPEYEVKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYNIEPVAGEESQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPNAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTGGFTANTTLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLAVEGNEIIREASKWSPELAAACEVWKEIKFEFEAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MURB_SINFN
Sequence: MKQVNGQKLLDALGNGVSAIRGRITPDAPMDRVTWFRAGGLAELMFQPHDTDDLVAFLKLVPEEVPVMVIGVGSNLLVRDGGIPGVVIRLSAKGFGDLEIVGENRIKAGAICPDKNIAAMALDHGIGGFYFYYGIPGSIGGALRMNAGANGGETRERVVEVHAVDRRGNRHVLSNADMGYSYRHTAAAKDLIFTHAIFEGFPEDKAKIRHDMDAVRQHRETVQPIREKTGGSTFKNPEGNSAWKLIDEAGGRGMMIGGAQMSPLHCNFMINTGQASGYELEYLGETVRAQVLEHSGIKLEWEIKRIGKFMPGYEIKEFLGRADG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_HELMI
Sequence: MKWREIAITTRQENADAMAEIFEAVGAMGMVIEDPQLIASYIESNVWDLHDVEIPDVPEGMIRVKTYLAIDNTLEERLAALQEELSARERSEKWPAHAWTMTDLHEDDWAHAWKAFFKPEKVGRRVVIRPTWEEYVPKEDDLVISIDPGMAFGTGTHPTTVMCIRALEDYVHAEAHVLDVGTGSGVLSIAAALLGAKRVLAVDNDPVAVATAQENVILNQVDEIVEVRRNDLLSGLSEQADILVANIIADVIIRLAPQAAALLAPEGIMIASGIIQNRLDDVVAAMTEKGFSIEELISHGEWAAIVARRAGVSAEG
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_BACC2
Sequence: MKTKTDFLKMKEQGEPITMLTAYDYPSAKLAEEAEVDMILVGDSLGMVVLGYDSTVPVTVEDMIHHTKAVRRGAKETFIVTDMPFMSYHVSLQETMMNARRIVQESGAHALKVEGAGEVISTIQYLTNAGIPVVAHLGLTPQSVGVLGGYKVQGKDAESAKKLIEDAKKCEEAGAIALVLECVPMQLAELISEQLTIPTIGIGAGQKVDGQVLVYHDLISYGVNRVPKFVKQYTSVQEEIVRGISQYVTEVKTRQFPEEKHSFTMKEEDRLALYGGKQ
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC14B_MOUSE
Sequence: MKRKSERRSAWATAPPCSRRSSSSSPGVKKSRSSTPQELHRLEQQDDLYLDITDRLCFAILYSRPKSATNEHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIIHFTGTDQRKQANAAFLVGCYMVIYLGRTPEDAYRTLIFGDTAYIPFRDAAYGSCSFYITLLDCFHAVKKAMQYGFFNFNSFNLDEYEHYEKAENGDFNWIIPERFLAFCGPHSRSRLESGYHQHSPETYIPYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFPDGSTPAESIVQEFLDICENVKGAIAVHCKAGLGRTGTLIGCYLMKHYRMTAAESIAWLRICRPGSVIGPQQQFLVMKQSSLWLEGDYFRQKLRGQENGPLREAFSKHLSDADDLSLNGLENQDNQEPEPYSDDDEVSGMTQGDRLRALKSRRQPKASAIPLTCPLAVLTSALCSVAIWWIVCDYILPTLLFCLDGFRTQ
What is the function of this protein?
Dual-specificity phosphatase involved in DNA damage response.  Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C).  Dephosphorylates SIRT2 around early anaphase.  Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis.  Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).
What are the official names of this protein?
Dual specificity protein phosphatase CDC14B, CDC14 cell division cycle 14 homolog B.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
Protein: CHS2_EXOJE
Sequence: EIEFTRTMHGIMRNISHFCSRTKSRTWGKDGWQKIVVCVIADGRQKVHPRTLNALAALGVYQDGIAKNIVNQKEVTAHVYEYTTQVSLDEGMKFKGAEKGIVPCQMIFCLKEQNKKKLNSHRWFFNAFGRALTPNVCILLDVGTKPDSKALYHLWKAFDQDSNVAGAAGEIKADKGKGWMCLLNPLVS
What is the function of this protein?
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
What are the official names of this protein?
Chitin synthase 2, Chitin-UDP acetyl-glucosaminyl transferase 2.
What is the protein family that this protein belongs to?
Belongs to the chitin synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL24_AGARV
Sequence: MATMKIKKGDLVKVIAGKDINNEGKVIAVNAKNNTLLVEGINMVTKHTKPSMSNQQGGIVHQEAPIDASNVMLIHDGKPTRVGFKMDGDKKVRFAKSTGKVID
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: ASTE_BURTA
Sequence: MISSADSGRDAAWLDDFLALTLAGGTPPAHAGECAAHAVRWRWLGDGLLQFEPVDATRRMQSVLVSAGVHGDETAPIELLSMLVRDIAHGALPLRCRLLVALGNPGAMRAGERYLDDDLNRLFGGRHAPLATSREAPRAAQLEAAASAFFATAGRARGARWHIDMHTAIRASVFEQFALLPHTGEPPTRTMFEWLGEARIAAVLLHTAKGSTFSHFTAQTCGALACTLELGKVMPFGANDLSRFARADAAVRNLVSGRRDAARAALPRVFTVVDQITKQSDALELFVEKDVPNFTPFAQGTLLARDGDYRYAVRHAQERIVFPNPSVKPGLRAGLLVVETTLDTHAALA
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: YD27_SCHPO
Sequence: MKVVSLRRIYSSEIYKLPTTRLHMDTLYYYYFVSHLAAALFVDLPITEWLGGSLSCLSGLRRFYLSTYEDPILLIPAPWKTALFSSELFFQVPFFIWVSLRLRKKARDPVLWVAILIYGVHAFTTTWCCMFELFAEKKWMIMSFYFPYLAIPLWMAIDMGGRLVKSCHAAKSGPSSTITSKSD
What are the official names of this protein?
Uncharacterized membrane protein SPAC56F8.07.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: WSC1_SCHPO
Sequence: MVFLNSSPFKGRLLFFVYLLIISTRLVAADMNTQYGCYLVDSSLTEQGTFTYLDPAYCYNNICGGSDNIAFVAIRNNQCYCGSTLTATEVSSSLCTTPCPGYGSLMCGGDLYWSVYLTGNGVLQTTVSSSSVSSTTSSSSSSSPSSSSTTTTTSPSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSVPITSSTSSSHSSSSSSSSSSSSSSRPSSSSSFITTMSSSTFISTVTVTPSSSSSSTSSEVPSSTAALALNASKASNHTSLNAGAIVGIVIGCVAFAVVMALCIFLYFYFRRFKIRMSDSANEGKYPSYASELDSRLDPAMMNRKSSESLADSQDYSRKILRVTNLN
What are the official names of this protein?
Cell wall integrity and stress response component 1.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: GCSPA_COXBU
Sequence: MPFIPHTPDDIEKMLAVIGAESIDQLFDEIPSALANIQQVPPGLNEAGITRLMEKREPNKQLCFIGAGAYEHHIPAAVWEIATRGEFYTAYTPYQAEASQGSLQLIYEYQTMMAELMAMDVSNASLYDGASALAEAALMAVRIKRGKAQRILVPASVNPFYRKVLSSIVEQQKINVEIIPFDPTMGIVNSELLKAKNAEGAAAIIIPQPNFFGCLEAVDVLTDWAHANDLLVIASVNPTAMALLKPPGQWGQKGADIVCGEGQPLGVPLASGGPYFGFMCCKKDYVRQLPGRIVGRTVDKKGREGFTLTLQAREQHIRRSKATSNICTNQGLAVVAATIYLSLLGATGLREVALASHTQSRDLFQRLSAVKGVSPVFSSPIFHEFVVRLEKPVEEVLAAMAEQGIQAGFSLKNDYPKLGNGLLICVTDTKTDDDLMAYENALRSIQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: NPIIE_ARTOC
Sequence: MQLIATLSALGALVATATAAAVPSAPVKQSVIDIQLSATGNTMIKATITNKGDQALNLLQFNTILDKNPTRKVRVYQNGTEVKFTGMLARYKMTGLSPDYFTTLSPKASVESSFDIARTHDLTRGGKITVMASGTIPTAEGHGANGTTITGYAKYESNKIELDVDAKKAASVVQAMGTVKKSPGSIDKRTNIDTSTCTQSQLDALEGALYNSAALAQAAAQAAPSNLDTVAEYFKSTSRRTINTIVSRLQSVASESTYVNSGSTTYYCTDVMNGCQPGVLAYTLPDQNIITNCPIYYSDLPALAQSCHEQDQATTTLHEMTHNSAVVSPYCDDLGYGYEDATSLSAGQAIQNADTYALFANVS
What is the function of this protein?
Probable secreted metalloprotease that shows high activities on basic nuclear substrates such as histone and protamine (By similarity).  May be involved in virulence.
What are the official names of this protein?
Probable neutral protease 2 homolog MCYG_01991, Deuterolysin MCYG_01991.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CQ067_HUMAN
Sequence: MKTLPVLVLSLTLLTVFSETSPILTEKQAKQLLRSRRQDRPSKPGFPDEPMREYMHHLLALEHRAEEQFLEHWLNPHCKPHCDRNRIHPV
What are the official names of this protein?
Uncharacterized protein C17orf67.
What are the subcellular locations of this protein?
Secreted.
Protein: AMPA_PSEE4
Sequence: MELVVKSVAAVSVKTATLVVPVGEGRKLGATAKAVDLASEGAISAVLKRGDLAGKPGQTLLLHSVPGLKAERVLLVGSGKDEALGDRAWRKLAASVAGVLKGLGGSDAVLALDDIAVTGRDGHYGKYRLLAETLLDSDYVFDRYKSQKAEPRALKKITLLADKAGLAEAERAVKHASAIATGMAFTRDLGNLPPNVCHPSFLAEQAKGLGKAHKGLKVEVLDEKKIKELGMGAFYAVGQGSDQPPRLIVLNYQGGKKSEKPFVLVGKGITFDTGGISLKPGAGMDEMKYDMCGAASVFGTLRAVLELQLPINLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFKPQAVIDIATLTGACIVALGSHTSGLMGNNDELVGQLLDAGKRADDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAGCFLSRFAKAYNWAHLDIAGTAWISGGKDKGASGRPVPLLTQYLLDRAGA
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y327_SHEAM
Sequence: MAIRDWPEGEGPREKLLQRGAAHLSDAELLAVLLRNGVSGQNAVDLARELIGEFGGLRPLFSATKQQVCRLQGLGPVKYAQLQASAELARRLAGESLQRGAVLTSPDLTRDYLRFQLADRAYEVFAVLLLDSQHRVIQFVELFRGTIDAASVYPRELVSLVLEKRAAAVIVCHNHPSGVAEPSQADRRITERLKNALATIDVSLLDHMVVGDREIVSFAERGWIG
What are the official names of this protein?
UPF0758 protein Sama_0327.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: TYSY_MYCVP
Sequence: MPIATPYEDLLRLVLDTGTTKSDRTGTGTRSLFGHQMRYDLNAGFPLITTKKVHTKSIVYELLWFLRGDSNVRWLQEHGVTIWDEWASPTGDLGPVYGVQWRSWPTPSGAHIDQISAALDLLRRDPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVSGGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLGVGEFIWTGGDCHIYDNHVEQVTEQLSREPRPYPELVLAQRDSLFDYIYEDVVIKNYDPHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3SA1B_NAJAT
Sequence: MKTLLLTLVVVTIVCLDLGYTLKCNKLVPIASKTCPAGKNLCYKMFMMSDLTVPVKRGCIDVCPKSSLLVKYVCCNTDICN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pore in lipid membranes.  In vivo, increases heart rate or kills the animal by cardiac arrest.  In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
What are the official names of this protein?
Cytotoxin 1b, Cardiotoxin-1b.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: KEAP1_HUMAN
Sequence: MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:15601839).  KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525).  In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:19489739, PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:29590092).  In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972).  The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357).  The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835).
What are the official names of this protein?
Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, INrf2, Kelch-like protein 19.
What is the protein family that this protein belongs to?
Belongs to the KEAP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly cytoplasmic (PubMed:15601839). In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62 (PubMed:20452972).
Protein: ATPH_LOLPR
Sequence: MNPLIAAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y946_LIMRD
Sequence: MESWLFLALVLLIAIFGHNSSLIIATVIVMVLKLIPYTAKWLPLIQHKGINWGVTVISVAILIPIATGQIGFNDLWAAFKTPAGWIAVGMGIAVAILSKYGVNQLAAVPQVTVALVLGTIIGVVAFKGIAAGPVIASGMTYCIVTLLNLHF
What are the official names of this protein?
UPF0756 membrane protein Lreu_0946.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LACB_NOTEU
Sequence: MKFLLLTVGLALIGAIQAVENIRSKNDLGVEKFVGSWYLREAAKTMEFSIPLFDMDIKEVNLTPEGNLELVLLEKADRCVEKKLLLKKTQKPTEFEIYISSESASYTFSVMETDYDSYFLFCLYNISDREKMACAHYVRRIEENKGMNEFKKILRTLAMPYTVIEVRTRDMCHV
What is the function of this protein?
Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
What are the official names of this protein?
Beta-lactoglobulin, Beta-LG.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KPRS2_ENTFA
Sequence: MSKHYFDPRLKIFSLNSNRPLAEKIADAVGVELGKCSVTQFSDGEIQVNIEESIRGAHVYVIQSTSSPVNDNLMELLIMIDALKRASAKTINVVMPYYGYARQDRKARAREPITAKLVANMIEKAGATRMLTLDLHAVQIQGFFDIPVDHLMGAPLIADYFIEHGIQGDDVVVVSPDHGGVTRARKLAEFLKAPIAIIDKRRPKANVAEVMNIIGHVEGKTCVLIDDMIDTAGTISLAANALKEAGAKDVYASCTHPVLSGPALQRIEDSAIERLVVTDSIYLSDDRKIVKIDEVSVGELIGDAIKRIHENKPVSPLFETKNK
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase 2, RPPK 2, 5-phospho-D-ribosyl alpha-1-diphosphate synthase 2, Phosphoribosyl diphosphate synthase 2, Phosphoribosyl pyrophosphate synthase 2, P-Rib-PP synthase 2, PRPP synthase 2, PRPPase 2.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_STRP6
Sequence: MGKCQVISHPLIQHKLSILRRQTTSTKDFRELVNEIAMLMGYEVSRDLPLEDVDIQTPVSKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGMYRNEETLEPVEYLVKLPEDINQRQIFLVDPMLATGGSAILAVDSLKKRGAANIKFVCLVAAPEGVKKLQEAHPDIDIFTAALDDHLNEHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: RS9_STAAM
Sequence: MAQVEYRGTGRRKNSVARVRLVPGEGNITVNNRDVREYLPFESLILDLNQPFDVTETKGNYDVLVNVHGGGFTGQAQAIRHGIARALLEADPEYRGSLKRAGLLTRDPRMKERKKPGLKAARRSPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: FTSB_VIBVY
Sequence: MRLFILVLTLLFGWLQYTLWFGKNGVSDYYTIESDIEAQQLVNTKLQARNSEMYAEIDDLKQGLDAIEERARHELGMLKEGETFYRIVGEENQ
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: YGIM_ECO57
Sequence: MPKLRLIGLTLLALSATAVSHAEETRYVSDELNTWVRSGPGDHYRLVGTVNAGEEVTLLQTDANTNYAQVKDSSGRTAWIPLKQLSTEPSLRSRVPDLENQVKTLTDKLTNIDNTWNQRTAEMQQKVAQSDSVINGLKEENQKLKNELIVAQKKVDAASVQLDDKQRTIIMQWFMYGGGVLGLGLLLGLVLPHLIPSRKRKDRWMN
What are the official names of this protein?
Uncharacterized protein YgiM.
What is the protein family that this protein belongs to?
To H.influenzae HI_1605.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.