PharMolix/UniProtQA huggingface dataset:
Protein: HIS1_CAMJR
Sequence: MQENTRLRIAIQKSGRLSKESIELLSECGVKMHIHEQSLIAFSTNLPIDILRVRDDDIPGLIFDGVVDLGIIGENVLEENELERQSLGENPSYKLLKKLDFGYCRLSLALPQENKFQNLKDFEGLRIATSYPQLLKRFMKENGINYKNCTLTGSVEVAPRANLADAICDLVSSGATLQANNLKEVKVIYESRACLIQKENALSKEKQALVDKIMLRVAGVMQARESKYIMLHAPKEKLDKIQALLPGVERPTILPLAHDEKNVALHMVSKENLFWETMEALKEEGASSILVLPIEKMLK
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y542_ACTP7
Sequence: MIITTTPTIDGHQITEYKGLVFGEVVSGANFIRDFFASITDVIGGRSGAYESKLNSARQEALAELEKEAKRVGANALVGVSMEYQSMGGDKGMFIVVATGTAVVIR
What are the official names of this protein?
UPF0145 protein APP7_0542.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: CINAL_MYCSS
Sequence: MSARAGIVVTGTEVLTGRVQDRNGPWIADRLLELGVELAHITICGDRPADIEAQLRFLAAEGVDLIVTSGGLGPTADDLTVATVARFCGRELILDTELEQRIADILRRLMGRRTDVDFDALRAANRKQAMVPDGATVLEPVGTAPGVVVPGSPTVLVLPGPPRELQPMWRTAVQTEALRSAIAGRTEYRQDMVRMFGLPESGLAETLRDAERDLAGFDRLEITTCLRRGELEIVTRYEPDAEPVYRNLLTLLRDRHGSAIFSEDGSLVDDQVAALLAGHTIATAESCTGGMLSARLTDRAGSSAYVAGAAVCYADAAKVELLGVPADLIADHGAVSEPVAEAMADGALRRFGADVAVAITGIAGPGGGTELKPVGTVCFCVRRADGRVVTRTVRLPGDRSDVRERSTTVAMHLLRRALQDG
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: GME66_PESMI
Sequence: MPTDTNSIIALSKSIGKLAREFENGATPSKEVQQALVLASEQLGVAAREPDDNVYNISGQISQNAAIRSAIALNAFALMPEDGSTITVEDISTKMNADPELVGRILRACASAHVFGHPTVNEYCHNNLSRVYLQGDHRQLAAQIYDFTGHAVLAIPDFGEEKQWKSMGDYVRGPFQLGFATDLSYMEYLQANPQRLKSWNSGMRTGKIGHRTSAFPFDRALELDPCGKDGIAIVDVGGGRGQALEGIHQDYPNLEGRLVLQDLPDVIKDAKANGLPDYIETTPGTFFDPLTAKGARIYHFRRVFHIWTQTKALELLENTKNAMNDYSRMLIADMVLADVGCERDLAMQDLNMMSLGGMERSESEWTSLIESAGLVLKKIWQNDQGPKHAVVEATLPTFKGHGLE
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of dibenzodioxocinones such as pestalotiollide B, a novel class of inhibitors against cholesterol ester transfer protein (CEPT) (PubMed:31474098).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS pks8/GME11356.  Pks8/GME11356 lacks a thioesterase (TE) domain, which is important to the cyclizing of the third ring of atrochrysone carboxylic acid, and the esterase GME11355 might play the role of TE and catalyzes the cyclization reaction of the C ring.  The lactamase-like protein GME11357 (or other beta-lactamases in Pestalotiopsis microspora) probably hydrolyzes the thioester bond between the ACP of pks8/GME11356 and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrates to form endocrocin anthrone.  Endocrocin anthrone is further converted to emodin via the endocrocin intermediate.  Emodin is then oxidized by several enzymes such as the Baeyer-Villiger oxidase GME11358, the oxidoreductase GME11367, the short chain dehydrogenase/reductase GME11373, as well as by other oxidoreductases from the cluster, to modify the A and C rings and open the B ring, and finally yield monodictyphenone.  The prenyltransferase GME11375 may catalyze the addition reaction between the C5 side chains and the carbon bone of dibenzodioxocinones.  The remaining biochemical reactions to the final product dibenzodioxocinones should be methylation catalyzed by methyltransferase GME11366 and reduction and lactonization reaction catalyzed by a series of oxidordeuctases (Probable).
What are the official names of this protein?
O-methyltransferase GME11366, Dibenzodioxocinones biosynthesis cluster protein GME11366.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: CWC22_CRYNJ
Sequence: MPRSLSRSVSPRPRSPSLSPPRPDSRSSRGRSLTPDDIPAYKRKRSPSPNPRDRPASPPTRRRRSQSPYRNSNRAEIDRPNVKDIDPNRRRARENALLEKQINMALADDGDADGTVATTKKSADEIARAEFAKLLGSRSGGAYIPPAKLRAMQAEAAKDKTSAEYQRISWDALKKSINGLINKVNISNIKHIVPELFGENLIRGRGLFARSVMRAQASSLPFTPVFAALVAIINTKLPQVGELVLIRLISQFRRAYKRNDKTVCHATSTFIAHLCNQYVAHEIVALQILLLCLDRPTDDSIEVAVGFMREVGQFLSENSPKANNTVFERFRAVLHEGQISKRCQYMIEVLFQVRKDKYKDNPAVPEGLDLVEEEEQITHRVTLDDELQVQESLNLFKADPNFVQNEERYNAIKREILGDSDDESGTESGSEYSESEDDEDEDVAPEKAGIQDMTETNLINLRRTIYLTIMNSLNFEEAVHKLMKVNIPEGREIELCNMVIECCSQERTYSNFYGLIGERFCKLHRIWTDAFQEAFQKYYDTIHRYETNKLRNIGRFFGHLLASDGISWAVLHVVHMNEEETTSSSRIFVKIVLQEMVEEMGINRVAERFRIPDLKPAFAGMFPMDNPKNARFSINYFTSIGMGKVTEDMREYLQNAPKLLAAQQAALAAAESSDSDTDSSSDISSSSDSDSDTDSDASSYSRRSRRRRYSSDSRSPPPRRRRYSSDSRSPSPPPRRRQYSDEPRSPSPPPRRRRYSDDSRSPSPPPRRRYSGDSRSPSPPPRRRYADDSRSPSPPPHRRRYSDDSRSPSPPPRRRRYSDNSRSPSPPPRRR
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC22.
What is the protein family that this protein belongs to?
Belongs to the CWC22 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: XERDL_STRMT
Sequence: MRDRISDFLEEKHGLSANSKQSYKYDLEQCLDIVGERISDTSLKIYQAQLANLKISAQKRKISGCNQFLYFLYHKGEMDSFDRLESAKQAEKKAEKPEILDLDSFWQGSDFPEGRLLALLILEMGLLPSEILALKVADINLDFQVLRIQKASQQRIVTIPTSLLSELEPLMGQTYLFERTGKAYSRQWAFRQLEAFVKEKGFPALSAQALREQFILRQIENKVDLYEIAKKSGLKTVLTLEKYR
What is the function of this protein?
Putative tyrosine recombinase.  Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site.
What are the official names of this protein?
Tyrosine recombinase XerD-like.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD-like subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_CAMJ8
Sequence: MKNIEKLEQSLTYEFKDKNLLIHALTHKSFKKSYNNERLEFLGDAVLDLVVGEYLFHKFAKDAEGDLSKLRAALVNEKSFAKIANSLNLGDFIFMSVAEENNGGKEKPSILSDALEAIIGAIHLEAGFEFAKTIALRLIEKNFPQIDAKILIKDYKTKLQEITQGKIGQTPQYETVRAFGPDHLKQFEIALMLDGKELARAIAGSKKEAQQMAAKIALEKLGAL
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA2_PSEPK
Sequence: MDTLTPKRRAIFEFIRERIAEHGQPPSLADIATRFGFASRSVARKHITALCQAGYIDVTPNQARGIRLAEPLRRPEILEIPVLGQVAAGAPIGPDLGIHEQLLLDPSLFRRTPDYLLKVRGDSMIDDGIFDGDLVGILQQADARDGQIVVARLDGEVTIKRLQRQGGTYRLLPRNPAYAPIDVQPEQDFFIEGVFCGLLRRD
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: HSLO_STAS1
Sequence: MTNDYIVKALAFGGQIRAYSALTTESVQEAQTRHYTWPTASAALGRTMTATLMMGAMLKGNQKLTVTVDGQGPIGKVIADADAKGNVRGYVTNPQTHFPLNDHGKLDVSRAVGTNGSLTVVKDVGLKDYFSGSSPLVSGELGDDFTYYFAKSEQVPSSVGLGVLVNPDNSIKASGGFLIQVMPGAEDETINKLEDAINHMTPVSKLIDQGLTPEELLFEILGEENVQILENVPAHFECNCGHDKFLNAIKGLGEAEIQNMINEDHGAEAECHFCRNKYQFSEEELQQLLDNIK
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMEDE_DROWI
Sequence: MRNQFICVALLLCALNSACGLYFHISETERKCFIEEVPDETTVIVNYKVELYDPRSNGFMPSSPGIGMHVEVRDSDDKVILSRVYSSQGRISFTSHTPGEHVICMYSNSTAWFSGAQLRVHLDIQVGEHAIDYANVAQKEKLTELQLRIRQLLDQVDQITKEQNYQRYREERFRHTSESTNSRVLWWSLAQTVVLVCMGFWQMRHLKSFFEAKKLV
What is the function of this protein?
Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo.  Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected.  Involved in Golgi organization (By similarity).
What are the official names of this protein?
Transmembrane emp24 domain-containing protein eca.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: ANR44_CHICK
Sequence: MAVLKLADQPPLVQAIFSGDPEEIRMLIYKTEDVNALDAEKRTPLHVASFLGDADIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKALKCAEIIIPMLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLEVVALLINHGAEVTCKDKKGYTPLHAAASNGQINIVKHLLNLGVEIDEMNIYGNTALHIACYNGQDSVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHNMFPLHLAALNAHSDCCRKLLSSGFEIDTPDSFGRTCLHAAAAGGNVECIKLLQSSGADFNKKDKRGRTPLHYAAANCHFHCIETLVTTGANINETDDWGRTPLHYAAASDMDRKKNILGNSHENAEELERTSEMKEKEAALCLEFLLQNDANPSIQDKEGYNTVHYAAAYGHRQCLELLLEKNSNMFEESDSSATKSPLHLAAYNGHHQALEVLLQSLVDLDIKDEKGRTALDLAAFKGHAECVEALISQGASVTVKDNVTKRTPLHASVINGHTPCLRLLLEVADNPDVTDAKGQTPLMLAVAYGHIDAVSLLLEKEASVDAADLLGCTALHRGIMTGHEECVQMLLEKEVSILCKDARGRTPLHFAAARGHATWLSELLQIALSEEDCSLKDNQGYTPLHWACYNGHENCIEVLLEQKFFRKFYGNSFSPLHCAVINDHENCASMLIGAIDASIVNCKDDKGRTPLHAAAFADHVECLQLLLSHSAQVNAVDHAGKTALMMAAQNGHVGAVDFLVNIAKADLTLRDKDSNTSLHLASSKGHEKCALLILDKIQEQSLINAKNNSLQTPLHIAARNGLKMVVEELLAKGACVLAVDENVSRSNGPRTSSATDVQKEE
What is the function of this protein?
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.
What are the official names of this protein?
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B, PP6-ARS-B, Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B, Ankyrin repeat domain-containing protein 44.
Protein: UPP_GEOSW
Sequence: MGKVYVFDHPLIQHKLTYIRDKNTGTKEFRELVEEVATLMAFEITRDLPLEEVEIETPVSKAKSKVIAGKKLGVIPILRAGIGMVDGILKLIPAAKVGHIGLYRDPETLKPVEYYVKLPTDVEERDFIVVDPMLATGGSAVEAINALKKRGAKSIKFMCLIAAPEGVEAVKKAHPDVDIYIAALDEKLNDHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: ASM_BOVIN
Sequence: MPRHGVSPGQGLPRSGREQASDRSLGAPCLRLLWLGLALALALPNSPVLWSPAEARPLPTQGHPAKFIRIAPQLQEAFGWWNLTCPTCKGLFTAIDFGLRNQASVAWVGSVAIKLCVLLKIAPPAVCQSAVQLFEDDMVEVWTRSVLSPSEACGLLLGSSCGHWDIFSSWNISLPAVPKPPPQPPKPPAPGSPVSRVLFLTDLHWDHDYLEGTDPNCENPLCCRRDSGPPPASQPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHNIWQQSRQDQLRALTTITALVKKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSHWLYEAMAEAWEPWLPAEALRTLRIGGFYALSPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVERYENTLAGQFFGHTHVDEFEVFYDEETLSRPLSVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYIMNLTEANEPGATPHWYLLYRARETYGLPNALPTAWHDLVYRMRKDTQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARSDSPALCRHLVPDASLPDVQSLWSMPLLC
What is the function of this protein?
This form is generated following cleavage by CASP7 in the extracellular milieu in response to bacterial infection (By similarity).  It shows increased ability to convert sphingomyelin to ceramide and promotes plasma membrane repair.  Plasma membrane repair by ceramide counteracts the action of gasdermin-D (GSDMD) perforin (PRF1) pores that are formed in response to bacterial infection (By similarity).
What are the official names of this protein?
Sphingomyelin phosphodiesterase, Acid sphingomyelinase, aSMase.
What is the protein family that this protein belongs to?
Belongs to the acid sphingomyelinase family.
What are the subcellular locations of this protein?
Lysosome. Lipid droplet. Secreted. Note=The secreted form is induced in a time- and dose-dependent by IL1B and TNF as well as stress and viral infection. This increase of the secreted form seems to be due to exocytosis of the lysosomal form and is Ca(2+)-dependent. Secretion is dependent of phosphorylation at Ser-504. Secretion is induced by inflammatory mediators such as IL1B, IFNG or TNF as well as infection with bacteria and viruses.
Protein: YME1_YEAST
Sequence: MNVSKILVSPTVTTNVLRIFAPRLPQIGASLLVQKKWALRSKKFYRFYSEKNSGEMPPKKEADSSGKASNKSTISSIDNSQPPPPSNTNDKTKQANVAVSHAMLATREQEANKDLTSPDAQAAFYKLLLQSNYPQYVVSRFETPGIASSPECMELYMEALQRIGRHSEADAVRQNLLTASSAGAVNPSLASSSSNQSGYHGNFPSMYSPLYGSRKEPLHVVVSESTFTVVSRWVKWLLVFGILTYSFSEGFKYITENTTLLKSSEVADKSVDVAKTNVKFDDVCGCDEARAELEEIVDFLKDPTKYESLGGKLPKGVLLTGPPGTGKTLLARATAGEAGVDFFFMSGSEFDEVYVGVGAKRIRDLFAQARSRAPAIIFIDELDAIGGKRNPKDQAYAKQTLNQLLVELDGFSQTSGIIIIGATNFPEALDKALTRPGRFDKVVNVDLPDVRGRADILKHHMKKITLADNVDPTIIARGTPGLSGAELANLVNQAAVYACQKNAVSVDMSHFEWAKDKILMGAERKTMVLTDAARKATAFHEAGHAIMAKYTNGATPLYKATILPRGRALGITFQLPEMDKVDITKRECQARLDVCMGGKIAEELIYGKDNTTSGCGSDLQSATGTARAMVTQYGMSDDVGPVNLSENWESWSNKIRDIADNEVIELLKDSEERARRLLTKKNVELHRLAQGLIEYETLDAHEIEQVCKGEKLDKLKTSTNTVVEGPDSDERKDIGDDKPKIPTMLNA
What is the function of this protein?
Catalytic subunit of the mitochondrial inner membrane i-AAA protease supercomplex required for mitochondrial inner membrane protein turnover.  The protease is probably ATP-dependent.  Important to maintain the integrity of the mitochondrial compartment.  Required both for the degradation of unassembled subunit 2 of cytochrome c oxidase (COX2) and for efficient assembly of mitochondrial respiratory chain.  Binds unfolded substrates in an ATPase-independent manner; binding of folded COX2, a physiological substrate, requires an active ATPase but when COX2 is destabilized an active ATPase is no longer necessary.
What are the official names of this protein?
Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1, Protein OSD1, Tat-binding homolog 11, Yeast mitochondrial escape protein 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Although this protein does not have any predicted transmembrane helices it behaves like an integral membrane protein.
Protein: RPOA_LOBMA
Sequence: MVREKVKVSTRTLQWKCVESRKDSKRLYYGRFILSPLMKGQADTIGIAMRRALLGEIEGTCITRAKSENIPHDYSNIVGIQESVHEILMNLNEIVLRSNLYGTRNALICVQGPGYITAQDIILPPSVEIIDNTQHIATLTEPIDLCIELKIERNRGYSLKMSNNFEDRSYPIDAVFMPVQNANHSIHSYGNGNEKQEILFLEIWTNGSLTPKEALHEASRNLINLFIPFLHVEEETFYLENNQHQVTLPLFPFHNRLVNLRKKKKELAFQYIFIDQLELPPRIYNCLKKSNIHTLLDLLNNSQEDLIKIEHFHMEDVKKILDILEKK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UB2JL_DICDI
Sequence: MSEHNSDIVHPPTKDCITRLKREFQEISKNPIENILVTPSPSNILEWHYVILGASNTPYEGGVYYGQLIFKYNYPLSPPSILMTTPSGRFETQKRLCLSISDYHPESWSPSWSTSSILLGLLSFMSDNEVTAGSIVTTNDEKRILATKSMDFNKKNKTFCELFPYLAMDE
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 J2-like, E2 ubiquitin-conjugating enzyme J2-like.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: PRP4_YEAST
Sequence: MSKYIALENLPVDLQHKGATQNESTADILKQLPHERLQAVLEKIPEEDLEVRRLLSILKKPEVVENEDVQQRRIRLAEILMVDEIDLENINNMENINGEEVDEEDDEDFFTPATSELIFARRFLINYSLERSRKRLQKEMERHQKFNTRQELLSRRTELQRMANLELAGSQLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN
What is the function of this protein?
Involved in RNA splicing.  Is required for the association of U4/U6 snRNP with U5 snRNP in an early step of spliceosome assembly.
What are the official names of this protein?
U4/U6 small nuclear ribonucleoprotein PRP4, Pre-mRNA-processing protein 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: KBTB2_CWPXG
Sequence: MDIENDIRNRRIIRNISNLLDDDILCDVIITIGDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHISSMNVIDVLKCADYLLIDDLVADCESYIKDYINHDTCIYMYHKLYEMVHIPIVKYIKRMLMSNIPTLITTDAFKKTVFEILFDIISTNDNVYLYREGYKVTILLKWLEYNHITEEQLLCILSCIDIQNLDKKSRLLLYSNKTINMYPSCIQFLLDNKQNRNIIPRQLCLACHDTNYNVCNPCILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTLGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTQHIDYTSVHTVNSIDMEEDTNISNKVIRYDTVNNIWETLPNFWTGTINPGVVSHKDDIYVVCDIKDEKNVKTCIFRYNTNTYNGWELVTTTESRLSALHTILHDNTIMMLHCYESYMLQDTFNVYTREWNHMCHQHSNSYIMHNILPIY
What is the function of this protein?
Probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins.
What are the official names of this protein?
Kelch repeat and BTB domain-containing protein 2.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: ORF8_SPV1R
Sequence: MVFSLYKNIYKFVNLLKIWIINLKVIIKIIISEIIVLIGNTIHDNQKIDGITFVKNEFIISSIFYFFFLFKIIYTERKP
What are the official names of this protein?
Uncharacterized protein ORF8, Gene 8 protein.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: RNPA_BURPS
Sequence: MQASAAFPKAARLLKTDEFSSVFRLRPWRRTAHFVIYGKPTGRDARLGLVIGKKYAARAVTRNLVKRLAREAFRTRRAEFAGWDILLRLHARFDKKAMPSAASAPLAALCAGEIRELLDRAAREVARRNGAKPASE
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: GPR62_MOUSE
Sequence: MANGSGLSVTELAGSVGFILAVLVEVGAVLGNGTLLVVVLRTPDLQDAFYLAHLCVVDLLAAASIMPLGLLAAPPGLGTVPLDPSSCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGARPAPALVLTAVWSAAALLGALSLLGPPPAPPPAPARCSVLAGGLGPFRPLWAMLAFALPALLLLAAYGSIFLVARRAALRPPRGTRPRSDSLDSRLSFLPPLRPRLLGGKAALAPALAVGQFAACWLPYGCACLAPAARAAAAEATVTWVAYSAFAAHPFLYGLLQRPVRLALGRLTRRALPRAPKACTSQAWHLQTLLRRLQELRKDPVLGPSEAPEQARELARQTPSVSEAT
What is the function of this protein?
Orphan G-protein coupled receptor.  Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28912303).  Has spontaneous activity for beta-arrestin recruitment (By similarity).  Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity).
What are the official names of this protein?
G-protein coupled receptor 62.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Colocalizes with ARRB2 in the endosome.
Protein: QUEF_NEIMF
Sequence: MSRNTEELQGISLLGNQKTRYPTGYAPEILEAFDNKHPDNDYFVKFVCPEFTSLCPMTGQPDFATIYIRYIPHIKMVESKSLKLYLFSFRNHGDFHEDCVNIIMKDLIALMDPKYIEVFGEFTPRGGIAIHPFANYGKAGTEFETLARKRLFEHDSQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_CHLL2
Sequence: MARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFLDESTSQSSNLTMGRVYKSVIDKERRGEYLGGTVQVVPHVIDEIKDRMAELAKNGNLDVLITEIGGTIGDIESLPFLEAMRQMKLEMGERNLLNIHLTFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVNDLDVIGLNDCDTIYEVPLMLLKEKLDLRVMKKLGLKKFKEPNLIYWREFCDKVNHPRDGEITIGICGKYTEYPDAYKSIIESFVHAGASNNVRVNIRLLKAEDAEGKTFDFAKELEGVSGILVAPGFGDRGIEGKIQYIRYAREQNIPFFGICLGMQCATIEFARNVCNLQEANSTEFNKRTRYPVIDLMEHQKKVKEKGGTMRLGSYPCILREGSRAYAVYQKFLINERHRHRYEFNNTFRKPFEENGMIFSGTSPNGELVEIVELANHRWFVGVQFHPELKSRVQKVHPLFHGFVEAAKEYSFGKRQMELPVERSAEMPSFMPAESDMGQ
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.