Protein: PHM1_PYRSX
Sequence: MTSSEPIAIIGSACRFPGGADTPSKLWELLKEPRDLLQKVPEKRRWHSEAFYHKDPEHHGTSNVSSSYFLDDDPASFDNTFFNIQPSECEAIDPQQRMLMETVYDSVCSAGQTIDGLRGSSTAVYVGMMCDDWSAILTKDAESIPQYSATGMGRSIMSNRISYFFDWHGPSITLDTACSSSLVAVHLAVQALRNGDCGTAIAAGVNLCLSPGMYIATSNLHMLSEGARSRMWDKDVDGYARGEGIASVVLKPLSAAIRDGDHIECLIRATGVNQDGKTQGLTMPSATAQTALIRQTYERAGLDIEKPEDRPQFFHAHGTGTPAGDPQEAEAISTAFYSGGLSDKLYVGSIKTVIGHTEGTAGLASLIGTSLALQHGVIPPNLLFNELNPRLIPFYNNLEVPTSAKPWPQLLPGQARRASVNSFGFGGTNAHAIVEAYEPPTSSGAADNVFAPLVFSAATEKSLRASLSAHGDYLQANPQVPLRNFAYTLQERRSTLAFRAVIPASNTTDAVERINALLDDADSVELGTKHFATPHPRLLGVFTGQGAQWPRMGAQIVEASPYASKKLGELDTALATLPPDVRPSWTLREEILADLEVSKVAEAAISQPLCTAVQILLVDLLTAAGIRFDAVVGHSSGEIGAAYAAGFISAETAIRVAYLRGFYAKLAGAAEMKGSMMAVGTSYEDALEFCQLEHFMGRISVAAVNSDSSITLSGNEDAIMEAVEIFKDEGKFARQLKVDTAYHSVHMLPCSEPYLKAMESVTQSTAPRDNTAGPRPTWYSSVLDGAVMGPGEVNSEYWVSNMVNPVLFSAAVAAAVSATGPFNLALEVGPHPALKGPCLDTLAAASGDSIPYSGLLSRSKNDILELSSALGFVWANLGASSVRFGDFEKLISGVSENPRPVKDLPKYAFDHTRSFWQISRASGAQFLAQDPPHPILGKRCLERETSQHVEWRNILSPKELPWLQGHRIQGGMVFPAAGYVAMAIEAMKIAVGKSRMSLIHIENLHIGRAMAFNQETSTMECLFRLNIVNSSPDSMKAKFSCCSGAPYETGTTMVLNAEGTVTVTLAEPEPDAIPYMKPKNFNMTEIEVDRFYTQIHKLGYEYSAPFRGMLSIQRKNAYALGTMEDQGGSDWEDQLLVHPGMLDTAIQSSSAAFGCPGDGMMWTLYIPTGIQSIIINPYYTTYATEKQEVLPWETISRGMVNTRTSMDINIFSQDNAHTFIQVEGLELVPFTAARPEDDANIFSSLEYRIDSPSGDLAVINDGWDSHSSEAAIKGERVSFFYLRRLLEEITPEEKEKTLPHYRHLLNWAAHVVARVSAGKNPCVPASCMQDTQEIIDSMWDGVRNRADIRLIESVGRNLIKVVREGSGILEHMDGLFDFYDQGLGLDRANRHLARMVGQLAHRYPHMNIFEIGAGTGGSTRNILSAIREEFSTYTYTDVSSGFFEAAQELFQDYEDRMIYSTYNMEHEPTSQGFEEGHYDLLLASNVLHATDKLEEMMLSARKLLKPGGYLIALELTNNDSMRVGLPMGTLPGWWLGAETGRPWGPTVTLPQWDSLLRKCGFGGIDTSTPIQHRLQASTIFAAQAVDDRVNLLRNPLSLVNNLPLTDAPRLVIIGGESLATHAIANNISSLLASHYSEIVRIVSFADLDLDVLPYGTAVLSLADLDEPVFKDISPAKLDALKTLWRQAFNIVWVTQGARAAEPYSSMMIGLGRAMIHEYPTISLQLMDIDTIADESRATQLIAKEFIRLELLNTFKRGTKSNLDLLWSIESEVTFEGSARLIPRLYLNKEANARYNSARRSIETQVNWKASLVTVALQGDTYGLSKPSPLRLPISQPSDTKVTSLNVSHFLLQGLKIDGLNPLVLCAGTERSTGKHLLALSHSLESQPEIQTKWSAPLPSGSDPSQIIAAVAAEIIADQITKLHTRSGIMIIHEATEQLAVALHTRAQTLGCQIVFTTSSKDHAQRGWQFIPQNISRRLIKRTLPADSNVFIDLSYSSASVAAGRLISGSVSKSCAKYTSDAFYSASVSSEFDLESSTKVEEAFQQAYDSVTQSKTGLVDPITIPIQEIGDVSVSQKPLAVVVSSATNLAVKVEAIDSGVIFRQDKTYLLIGMSGQVGQSLCQWMVKCGARHVVLTSRRPLVHDDFIESMKDLGANVRTFALDITQRESLHKCYEEIVATMPPIAGVANGAMILRDSMFDGMTFQNLTTVLEPKVAGTRYLDELFYDAPLDFFIVLSSITSLVGNSSQSNYTAANMFMVALVEQRRKRGVPGSAISISALIGIGYVENSEFTGEYFENIGLRNISEQDLHQQFAEAILAGRPETQGSSEVAIGLIPFYPERDDKAQFHTDIKFNHLMLERKDAQIHGGKGSALPVRVQLAEAKTKDQAATIIKDGFMVRLKRTLMIGLDEVVNEKVPLVEQGIDSLMAVEIRAWFLKELDVDIPVLKVLGGSNITELLQEAMDRTPSTIIDFSSLSNAKAAAPVTNTATPPPEVQVTGSASDSSRSLTPDGLSTSRPSTPVRTPMTEINDPTPSFSLLSVAPDIAPKVPESVSPMSYGQARFWFLSDYLEDKTSFNMTVMFKLTGRLQVPRLERAVRTIAHRHDALRTRFFWGGEGDKRIAMQGISAESSIELEHVRINSEADAKNELRKMHEFVWDLDSHQAARMVLLTINENEHYFMTSGHHISWDGYGFTVLFIDLDAAYRGEPLSPNGPETQYPAFAAWQRDTYAAGAMKKSIDEYYRPMIDPEARPLPLFPFARAPNRPLLDHFEQFEAKVTLQPHVVSKLKQVSRKNGATMFHLYLAALQALVFRLLPEEQSFYLGVADANRLDKNFMGSLGFFLNLLPVRFDRTAPGTKSSDMIKDTRNKAYKALENSFVPWDVLLHELKIPRTNTEAPIFQLFVDYRQIVRERAQWCGCSMSDEDWLNARNGYDLTLGITDNPTGESLLSLRFQKKLYSEESTEMFLRSYVNVLEALASGKDLLVDDLPRWAGADVEEALNVGRGPQLELEWPVTVSHRIDQMIGTYASKPALQDEHNNCMSYEQMGHRINTIAAALIQAGTTTGTPVGVFQTPSSDWICSMLAIFRVGATYIPLDLRNSVARVSFIVEIAQPLILLTDRETTLHVAEIQASNATEIIIPDLSTTTMPLSMENQARPDSPAVTLFTSGTTGRPKGVVLTHANLRAQCEGYSRMVNLQSMTSVVLQQTNYNFDVSLDQIFAALAEGGCLYVVPASKRGDPQAITKIMAEKGVTYTVATPSEYETWFRYAPETLAECKSWGYAFGGGEHLNNGLIGEFAALSTRHIPELRLFNNYGPTEASLAITKGEVDFKRPDLEKHVPAGMTIPNYAVAIVDENLKPVPLETVGEIVAGGPGVAAGYLGQADLTREKFISGHDVHRLAAQHSDRWYRTGDRGYLRPDGALFVHGRILGDTQVKIRGFRVELQEIENVVLETAKGALTHAVVSLRGTGEDKFLTAHVVFAPDFAMHLRQDLIRHLEAALPLPSYMQPTVIVPLTKVPVTTNFKIDRNAIQAMPLPQAVAGTDNLANMEGRVAALWRIIIPHLTQELTPESDFFAVGGNSILLVKLQAAIKRELQSSPQLIDLINSSSLEGMARHVRAAFINRIDWDLETAVPADLKEDLEVLTSQPRKHGQDDLTVVITGSTGYLGRHVLAHLVDSSNVRQIICLVRPEHLQTASPLSTSSKIRLVAADISQPSLGLGAQTFAELAQITDIVFHCAANRSFWDGFESLRHVNFDAAKELARLCVANDAVLHFMSSGAVSKYNDISPPTDGSDGYIASKWAAEEFLRRVAKFGLRVQVHRPLALPSEKVSSLSQEDLKRVQDELPRLIAQIGQRPEFSAIHGHIDVRPVSDVATTLVEDMLVSSVQESGNEATVKNHAAHLRLQIKTFAEQIDADEELSKLPTMDALQWFGAAKRAGFGWLIGAMEMHIEGDDQSGTTTQVLVQR
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of the trans-fused decalin-containing tetramic acid phomasetin, the stereochemical opposite of the HIV-1 integrase inhibitor equisetin (PubMed:29972614).  The PKS module of phm1 together with the enoylreductase phm4 catalyze the formation of the polyketide unit which is then conjugated to L-serine by the condensation domain of the phm1 NRPS module (PubMed:29972614).  Activity of the Dieckmann cyclase domain (RED) of phm1 results in release of the Dieckmann product intermediate (PubMed:29972614).  The Diels-Alderase phm7 then uses the Dieckmann product of phm1 as substrate and catalyzes the Diels-Alder cycloaddition to form the decalin ring of N-desmethylphomasetin (PubMed:29972614, PubMed:34121297).  N-desmethylphomasetin is further methylated to phomasetin by the methyltransferase phm5 (PubMed:29972614).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase phm1, PKS-NRPS phm1, Phomasetin biosynthesis cluster protein 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.