PharMolix/UniProtQA huggingface dataset:
Protein: PPE2_MOUSE
Sequence: MGSSSSTQHHFAFQNAEKAFKAAALIQRWYRRYMARLEMRRRCTWNIFQSIEYAGQQDQVKLHEFFSYLVDHFTPSSHHERDFLNRMFTEERFAQDVETEEGGDFESIEVPDSYTGPRLSFPLLPDHATALVEAFRLRQQLHARYVLNLLYETRKHLAQLPNINRVSTCYSEEVTVCGDLHGQLDDLIFIFYKNGLPSPERAYVFNGDFVDRGKDSVEVLMVLFAFMLVYPKEFHLNRGNHEDHLVNLRYGFTKEVMHKYKIHGKKILRTLQDVFCWLPLATLVDEKVLVLHGGVSDKTDLELLAKLDRHKIVSTMRCKTRKESENREEQKRKDNQTSSGQKPTPWFLPQSRSLPSSPFHLGSGFKAYKAGRSCSIPCGSPNSKELSRRGQVRRSVDLELEQCRQQAGFLGIREKGESLPLAPDADCVADGGGVLEPTPEEWKQVVDILWSDPAAQEGCKANAVRGGGCYFGPDVTERLMEKYKLQLLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANKATHRLTMRQRISRVEESALRALRQKLFAHSSDLLVEFRKRDPDESGVITLSDWATAVESVLHLGLPWRMLRPQLVNSSADNVLEYRSWLDSLAKEQLSRENIQSSLLEKLYRNRSNLETIFRIIDSDHSGFISLDEFRQTWKLFSSHMSIDITDDGICDLARSIDFNKDGHIDINEFLEAFRLVEQSCLEGHASACLQSTDTAESGHSSPGPC
What is the function of this protein?
May play a role in phototransduction.  May dephosphorylate photoactivated rhodopsin.  May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.
What are the official names of this protein?
Serine/threonine-protein phosphatase with EF-hands 2, PPEF-2.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family.
Protein: SKN1_CAEEL
Sequence: MGGSSRRQRSTSATRRDDKRRRRQCFSSVADDEEETTSIYGVSSIFIWILATSSLILVISSPSSNTSIQSSSYDRITTKHLLDNISPTFKMYTDSNNRNFDEVNHQHQQEQDFNGQSKYDYPQFNRPMGLRWRDDQRMMEYFMSNGPVETVPVMPILTEHPPASPFGRGPSTERPTTSSRYEYSSPSLEDIDLIDVLWRSDIAGEKGTRQVAPADQYECDLQTLTEKSTVAPLTAEENARYEDLSKGFYNGFFESFNNNQYQQKHQQQQREQIKTPTLEHPTQKAELEDDLFDEDLAQLFEDVSREEGQLNQLFDNKQQHPVINNVSLSEGIVYNQANLTEMQEMRDSCNQVSISTIPTTSTAQPETLFNVTDSQTVEQWLPTEVVPNDVFPTSNYAYIGMQNDSLQAVVSNGQIDYDHSYQSTGQTPLSPLIIGSSGRQQQTQTSPGSVTVTATATQSLFDPYHSQRHSFSDCTTDSSSTCSRLSSESPRYTSESSTGTHESRFYGKLAPSSGSRYQRSSSPRSSQSSIKIARVVPLASGQRKRGRQSKDEQLASDNELPVSAFQISEMSLSELQQVLKNESLSEYQRQLIRKIRRRGKNKVAARTCRQRRTDRHDKMSHYI
What is the function of this protein?
Directed by the ER-associated degradation pathway (ERAD), mediates proteasomal homeostasis by regulating the expression of proteasomal subunits such as rpt-3 to confer resistance to proteasomal dysfunction.
What are the official names of this protein?
Protein skinhead-1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Skn1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In absence of stress, localizes in the cytoplasm of intestinal cells (PubMed:16166371, PubMed:22216003, PubMed:26920757). Upon paraquat or arsenite treatments or upon bacterial infection, localizes in the nucleus (PubMed:16166371, PubMed:22216003, PubMed:26920757). Nuclear localization is regulated by pmk-1-mediated phosphorylation (PubMed:16166371, PubMed:26920757). Nuclear localization is regulated by transcriptional coregulator hcf-1. SUBCELLULAR LOCATION: [Isoform a]: Nucleus. Mitochondrion. Note=Localizes to the nucleus in response to proteasomal dysfunction. SUBCELLULAR LOCATION: [Isoform b]: Nucleus. Note=Localizes to the nucleus in response to pathogenic bacteria such as P.aeruginosa or E.faecalis, in a nipi-3-dependent manner. SUBCELLULAR LOCATION: [Isoform c]: Nucleus. Note=Localizes to the nucleus in response to pathogenic bacteria such as P.aeruginosa or E.faecalis, in a nipi-3-dependent manner.
Protein: PSD_GLAP5
Sequence: MQLKSYPAPTYAQRAKIAFQYMMPQLYLTQAAGWLAERKWGVITHFIINVFAKKYQVNLAEAEKTKASDYASFNEFFIRPLKENARPINQNPQALCLPADGRVSELGKIEENQLLQAKGHQFSLETLLANDLNLADKFKNGNFITTYLSPRDYHRVHMPCDATLRKMIYVPGELFSVNPFLAEHVPNLFARNERLICEFETAFGPMVQILVGATITASMSTVWAGVINPPRAKEVAVYEYLPTGETAVHLKKGQEMGAFRLGSTVINLFPKGAVELEAHLKAGEPTKMGERLGKINL
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YQGF_MYCLE
Sequence: MFSSQHRLLYQPSGPDLSKNLDPERGRRLGIDVGSVRIGVAFSDPDGILATPVETVRRYRSAKHLRRLAELVVELQVVEVVVGLPWTLTDRTGSSAKDAIDTAEALARRVAPVPVRLVDERLTTVSAQRLLRAAGVRAKDQRAVIDQAAAVVILQNWLDQCRAATPARADEPTTGSVAGEVIDG
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNFL6_PIG
Sequence: MQQPFNYPYPQIFWVDSSATSPWASPGSVFPCPASVPGRPGQRRPPPPPPPPPPPPTLLPSRPLPPLPPPSLKKKRDHNAGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELTELRESASQRHTESSLEKQIGHPNLPSEKKELRKVAHLTGKPNSRSIPLEWEDTYGIALVSGVKYMKGSLVINDTGLYFVYSKVYFRGQYCNNQPLSHKVYTRNSRYPQDLVLMEGKMMNYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESKTFFGLYKL
What is the function of this protein?
Cytoplasmic form induces gene transcription inhibition.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 6, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Note=Colocalizes with the SPPL2A protease at the cell membrane. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted. Note=May be released into the extracellular fluid by cleavage from the cell surface. SUBCELLULAR LOCATION: [FasL intracellular domain]: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus.
Protein: AROB_SULDN
Sequence: MQVHIELKKVVDNSYDITIGTLPTLHFDTKVAVVTNSTISALHLEYLLSKISAKELYVVTLRDGEEYKNQQSIDTILEALFENRFNRKSMIIAFGGGVIGDMSGYAASIYQRGIDFIQIPTTLLSQVDASVGGKTGMNNRYGKNLVGAFHQPRAVYIDPHFLTTLPPREFGAGVAEIVKMAVTFDKDFFEFLERADLSKPEILQEAIKKALQTKAKVVTQDEKEQGIRAALNYGHTFGHVVENETAYKEFLHGEAVAIGMVMANEMAIKMNYMFEKEALRVKALLQKYNLPTTYAIKDVKAFYEAFFLDKKSSDSAITFILPLGIGDVVITDKVDTGTIMCVLNKFGKQ
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSC_SERP5
Sequence: MKRVAFVFTQGPHGNAGGREGLDALLATSALSEDLGVFFIGDGVLQLLPGQQPEKILARNYIATFGVLPLYDVERCYLCQASLQERGLSQVTDWVLDAEVLAPDALGQLLAGYDAVMTF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_AROAE
Sequence: MQTTQETQGALERRIDMSVPMAEIDKEVDSRLKRMARTVKMPGFRPGKVPMKIVAQTYGSQARSEAIGAAVEKAFGDKVREQNLRVAGYPRIEPREAAVEGALEFSAVFEVYPQVPLGDLSGQKVERPVLTVGDAEVDKTIEVLRKQRTTFEAVDRPAQDGDRVVIDFAGRKDGELFEGGKAQDFPFVIGAGSMLKDFESAVGGLKVGETKTFEMTFPEDYHAADLAGQKVEFEITVKGVEAPILPAVDADLARALGVADGDVTKLRDEVRANLEREVKRRIQGKVKEQVMEALLVANPIEVPKALVEAESRQLAENAKRDLEMRGMNTKDIPVEPTWFADQAVRRVKLGLIMAELVNAKELYAKPEQVRAMIDEMAQSYEDPAELVRWYYAQPERLGQAEAVVIEDNVVAWVLSQTQTEDKTVTFDELMGNAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PRRC1_RAT
Sequence: MMEESGIETTPPGTPPPHSAGLAAVPSTEAHLAVTSSFSSPNTSGMETVPPHSYSTPQSSLPPVQPSAPPPFVPLSPAPSTPLSGTSVPPSVSPSPATAFSGPPLSHFPPATSASGALLSAPPSGPPISGFSVGTTYDITRGHAGRAPQTPLMPSFSAPPVTGILPAPITQQASMTSLAQGPGTTSAITFPEEQEDPRISRGQDDAPAGGIWGFIKGVAGNPMVKSVLDKTKHSVESMITTLDPGMAPYIKSGGELDIVVTSNKEVKVAAVRDAFQEVFGLAVVVGEAGQSNIAPQPVGYAAGLKGAQERIDSLRRSGTIHEKQTAVSVENFIAELLPDKWFDIGCLVVEDPVHGIRLEAFTQATPVPLEFVQQAQSLTPQDYNLRWSGLLVTVGEVLEKSLLNVTRTDWHLAFTGMSRRQMIYSAAKALAGMYKQRLPPRPL
What are the official names of this protein?
Protein PRRC1, Proline-rich and coiled-coil-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PRRC1 family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: LON_ECOLI
Sequence: MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLESPTIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMPKEAKEKAEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRGLEREISKLCRKAVKQLLLDKSLKHIEINGDNLHDYLGVQRFDYGRADNENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPSGMQVVTAK
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.  Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, UmuD and at least type II antitoxins CcdA, HipB and MazE (PubMed:8022284, PubMed:16460757, PubMed:22720069, PubMed:24375411).  Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system (PubMed:15009896).
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPRK1_DROME
Sequence: MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVASVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQEVSETVFDTVNTETDKLEQKRKLKQKQHFDADEKESDCILHGYIKKLGGSFASLWQTKYAKLYPNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEWSSSLRSAHKISQDLLGSMAKKAGKIYGSERDVNKSMYIFGGNCSTKTSNGSN
What is the function of this protein?
Specifically phosphorylates the activated forms of G protein-coupled receptors.
What are the official names of this protein?
G protein-coupled receptor kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Protein: SYA_RHOP2
Sequence: MSGVNDIRSAFLNYFAKNGHDIVPSSPLVPRNDPTLMFTNAGMVQFKNVFTGLEKRPYQRATTSQKCVRAGGKHNDLDNVGYTARHLTFFEMLGNFSFGDYFKERAIELAWNLITKEYGLKKDKLLVTVYHTDDEAASYWKKIAGFSDDRIIRIPTSDNFWAMGDTGPCGPCSEIFIDQGEHIFGGPPGSPEEDGDRFLEFWNLVFMQYEQVTKDERLPLPRPSIDTGMGLERMANILQGVDSVFETDLFRSLIDATSSALGRGPGEEDAASFRVIADHLRSSSFLIADGVLPSNEGRGYVLRRIMRRAMRHAQLLGASEPLMWRLVWALVREMGQAYPELVRAEAMIEETMRLEETRFRKTLDRGLAILDEKSASLKKGDMFDGDTAFTLYDTYGFPLDLTQDALRNRGISVDIASFTDAMDRQRAKARASWAGSGEAATETVWFGLREKLGATEFLGYDTETAEGVVTALVADGKEVDALKAGDSGAIVLNQTPFYAESGGQVGDTGVLSGDGVRFRVTDTLKKAGDLFVHFGTVEEGAIKRDAALQLDVDHARRSSIRANHSATHLLHEALRQVLGDHIAQKGSMVAPDRLRFDFVHQKPITPDELRRVEDIANDIVLENDEVTTRLMAVDDAREAGARALFGEKYGDEVRVVSMGKTARDSGSNALGWSVELCGGTHVKRTGDIGLVSITGESAVASGVRRIEALTGRYARQSANAAINTAKQAAAELRTTVDDMPARIAALMEERKKLERELSDARKKLAMGGGGAAGAADGGADVREVGGVKLMARAVEGIEIKDLKSLVDQGKKQLGSGVIALVATSEDGKGSIVVGVTPDLVARFSAVDLVRTASVVLGGKGGGGKPDMAQAGGPDGSKAQAALDAIAAAIGG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEAK1_MOUSE
Sequence: MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDSEKTPITHGSGKTNANHSNNHRVRSTGNFRPPVAKKPTIAVKPTMMVADGQSVCGELSIQEHCENKPVILGWNQNKTSLSQKPLNNNSEGDAEGFGSDPQQCANNDSAQKISNNNNGLTEVLKEIAGLEATPPVRGNETNARETFLGRINDCYKRSLERKIPPSCMTGSMKDSQGKHVILSGSAEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEIRMRGQPRFANFRANTLSPVRFFVSKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSGVSYGQGSVQSTISSDCTSPGSSFTEESRSETASSLSQKVCNGGISPGNPGNSKDIAETESNFESPPGNNEEKDESLTSKSSVKVPETHKAVLALRLQEKDGKIAVHTEKPESKASTDIAGQAVTISLVPVEEQTKPYRVVNLEQPLCKPYTVVDVSAAMASEHLGRPKIKGSSSTPNSPVTSPALTPGQINAHLKKSSAIRYQEVWTSSTSPRQKIPKIELSTGGPGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPSYARSSKNAIKVPIVINPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESKVSDSTPSKLTDCPQAKGFSNSTERKRGSVAQKVQEFNNCLNRGQSSPQRSYSSTHSSPAKIQRPTQEPAGKTEGAQGSQVPGSSSNSTREKASAVLCQIVASIQPPQTPPEAPQSSPKACSVEELYAVPPDADTTKSIPKNPPVRPKSLFTSQSSGEGEAHQTTESPTAKIQKDPSTKPVTSPPSKLVTSAQSEPPPPFPPPRSTSSPYHASNLLQRHFTNWTKPTSPTRSTEAESILHSEGSRRAADAKPKRWISFKSFFRRRKTDEEEEKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGEASEKPAIVFMYRCDPDQGHLSVDQSKAGAEKGRAEEVLLRNSEEKKSSYLPSQIPDKACSRVTHEVAGELSPRDPRTPAGKQDGTSVTPTLPPPDLEREEEKDDTLDPTDVSPCSATYSNLGQSRAAMIPPKHPRHPKGAVDDAIAFGEKTDQEGLNASQPTPPPLPKKMIRANTEPISKDLQKAMESSLCVMANPTYDIDPNWDASSAGSSISYELKGLDVESYESLERPLHKERPVPSAANSISSLATLSVKDRFSNSMESLSSRRGLSYRQTRSIQKPQRQALYRGLDNREEVVGKLRSLHTDALKRLAVKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYYTASYAKDPLSNYAVKICKSKAKESQQYYHSLAVRQSLPVHFNIQQDCGHFLAEVPSRLLPWEDPDAPEKAEDGTEDSEEEGKAETLGGNPEPCSETEPSQKENQRVTNRKQRSHVVVITREVPHLTVADFVRDSLAHHGNSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVQHQPGGAAQGPSPADPCPTLACPTRLIVSNFSQAKQKSHLVDPQILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLPNPFDENPELKEKEYTRTDLPRIPLRSPYSWGLQQLASCLLNPNPSERILISDAKGILQCLLWGPREDLFQIFTTSATLAQKNALLQNWLDIKRTLLMIKFAEKSLDREGGISLEDWLCAQYLAFATTDSLSYIVKILQYR
What is the function of this protein?
Probable catalytically inactive kinase.  Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics.  Acts as a scaffold for mediating EGFR signaling.
What are the official names of this protein?
Inactive tyrosine-protein kinase PEAK1, Pseudopodium-enriched atypical kinase 1, Sugen kinase 269, Tyrosine-protein kinase SgK269.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Note=Colocalizes with actin (PubMed:20534451).
Protein: CHAB_SHIFL
Sequence: MPYKTKSDLPESVKHVLPSHAQDIYKEAFNSAWDQYKDKEDRRDDASREETAHKVAWAAVKHEYAKGDDDKWHKKS
What is the function of this protein?
Might be a regulator of the sodium-potassium/proton antiporter ChaA.
What are the official names of this protein?
Putative cation transport regulator ChaB.
What is the protein family that this protein belongs to?
Belongs to the ChaB family.
Protein: FETP_PSEPK
Sequence: MTRTVMCRKYQEELPGLERPPYPGAKGQDIFEHISQKAWADWQKHQTMLINEKRLNMMNAEDRKFLQAEMDKFFAGEEYAQAEGYVPPAE
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: MYB1W_BETVU
Sequence: MYQNSEAGSLGRVVKGSWSDEEDDLLRKCIQKYGEGNWKRVPERAGLNRCRKSCRWRWLNYLKPSIKRGHFNEDEVKFIIQQHKLLGNRWSLIAAKLPGRTINDVKNYCNTHLYKKHSIENIPAPATNTMTHNTSSCVERPESSAAIKEPTWWENILVELQREEKEGKSQNCSGLDFEQDNLGQQDPNINDGMDQWLNSLREVPNLSYQWEENLLDFDVVNLWA
What is the function of this protein?
Activates DODA1 and CYP76AD1 in the betalain red pigment pathway.
What are the official names of this protein?
Transcription factor MYB1, BvMYB1, Anthocyanin MYB-like protein 1, R2R3 MYB transcriptional regulator 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: KHSE_CAMFF
Sequence: MKILTPATSANLGPGFDSLGLSLKLYNEVTITKQNFTSVCISGEGSDKIGLKKNNTFVNIFNETMLYLTGKTPNFRFNFINNIPFSRGLGSSSSVIVGAIASAYHMAGFKVDRALVLNQALKYESHPDNISPAVWGGFTSNIVHKGTVYTQKADISSDLRAVVVIPDKPTSTKQSRGKLPKTYPMADVISNVSHAAFLTACFIKQDYENLRLASIDKMHEIRRMHGLKELFRVREIAYLSGALMSNLSGSGSSFLNLAHKDRAQTLRDILQLEFPEFKVEIYELDNNGFILQS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_ECOBW
Sequence: MSAIAPGMILIAYLCGSISSAILVCRLCGLPDPRTSGSGNPGATNVLRIGGKGAAVAVLIFDVLKGMLPVWGAYELGVSPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKFKRKREKDPE
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSD_ACIBC
Sequence: MSFTSRLKKELFIKAQNLVPQHQLSRVVGKVAASENPILKAAVIHAFKTKYGIDLSIAEQGNALKYKSFNDFFTRALKDGVRLVDENPDSIVSPADGAISQIGKITAGEVFQAKGQSFSVEKLIGDPQLAQPFQEGEFATVYLSPRDYHRVHMPFSGTLTETLYVPGELFSVNQVTAENVPGLFARNERMVCLFDTELGRMAVVLVGAMIVAGIETVATGKVKPSGRIELQHHELKLEKGAELGRFYLGSTAIILFEKDKIEWEKRFKAESVVVMGERMGHTI
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: VP4_ROTHW
Sequence: MASLIYRQLLTNSYSVDLHDEIEQIGSEKTQNVTINPSPFAQTRYAPVNWGHGEINDSTTVEPILDGPYQPTTFTPPNDYWILINSNTNGVVYESTNNSDFWTAVVAIEPHVNPVDRQYTIFGESKQFNVSNDSNKWKFLEMFRSSSQNEFYNRRTLTSDTRFVGILKYGGRVWTFHGETPRATTDSSSTANLNNISITIHSEFYIIPRSQESKCNEYINNGLPPIQNTRNVVPLPLSSRSIQYKRAQVNEDIIVSKTSLWKEMQYNRDIIIRFKFGNSIVKMGGLGYKWSEISYKAANYQYNYLRDGEQVTAHTTCSVNGVNNFSYNGGSLPTDFGISRYEVIKENSYVYVDYWDDSKAFRNMVYVRSLAANLNSVKCTGGSYNFSIPVGAWPVMNGGAVSLHFAGVTLSTQFTDFVSLNSLRFRFSLTVDEPPFSILRTRTVNLYGLPAANPNNGNEYYEISGRFSLIYLVPTNDDYQTPIMNSVTVRQDLERQLTDLREEFNSLSQEIAMAQLIDLALLPLDMFSMFSGIKSTIDLTKSMATSVMKKFRKSKLATSISEMTNSLSDAASSASRNVSIRSNLSAISNWTNVSNDVSNVTNSLNDISTQTSTISKKFRLKEMITQTEGMSFDDISAAVLKTKIDMSTQIGKNTLPDIVTEASEKFIPKRSYRILKDDEVMEINTEGKFFAYKINTFDEVPFDVNKFAELVTDSPVISAIIDFKTLKNLNDNYGITRTEALNLIKSNPNMLRNFINQNNPIIRNRIEQLILQCKL
What is the function of this protein?
VP8* Forms the head of the spikes and mediates the recognition of specific host cell surface glycans (PubMed:17306299).  It is the viral hemagglutinin and an important target of neutralizing antibodies (By similarity).  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (PubMed:24501414).  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry (By similarity).
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: GRPE_SHIF8
Sequence: MSSKEQKTPEGQAPEEIIMDRHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YABA_LATSS
Sequence: MSKTDLYEQLLTIEQQAKLTFDGITEMKAVLSKVLEENAELEIENKHLREHLQELQQTTEETDTKDLSQGLSKSKQNLQNLYEEGFHICPYFYGSRRENDEPCAFCNDVIYGERTAD
What is the function of this protein?
Involved in initiation control of chromosome replication.
What are the official names of this protein?
Initiation-control protein YabA.
What is the protein family that this protein belongs to?
Belongs to the YabA family.