PharMolix/UniProtQA huggingface dataset:
Protein: DADA1_PSEPK
Sequence: MRVLILGSGVVGTVSAYYLAREGFEVVVVDRQDGPAMETSFANAGQVSPGYASPWSAPGVPLKAIRWMLQQHAPLAIKPTSSLDQYRWMIQMLRNCNPASYAVNKERMVRISEYSRDCLDELRAETGISYEARQLGTTQLFRTQAQVDNAAKDIAILKQSGVPFELLDRDGIAKAEPALASVRDKLAGALRLPNDQTGDCQMFTRKLAKMAEELGVEFRFGCNIDRLECSGDTISGVWIDGKLEVADQYVLALGSYSPHMLKPLGIQAPIYPLKGYSLTIPITDASMAPSSTILDETYKVAITRFDDRIRVGGMAEIAGFDLSLNARRRDTLELVVGDLYPKGGDLTKATFWTGLRPATPDGTPIVGKTKYRNLFLNTGHGTLGWTMSCGSGRLLADLMAGKKPKISAKGLDISRYSNQKEAHNHGNPATAL
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: QSEB_ECO57
Sequence: MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTARDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLELLMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK
What is the function of this protein?
Member of a two-component regulatory system QseB/QseC.  Activates the flagella regulon by activating transcription of FlhDC.  Currently it is not known whether this effect is direct or not.
What are the official names of this protein?
Transcriptional regulatory protein QseB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_HELHP
Sequence: MNIIEGKLQLIGDERIAIISSRFNHLITDRLVEGAKDCFVRHGGRDDLLDLVLVPGAYEIPFALQKILSQGEYDGICCLGAVIRGSTPHFDYVSAEATKGIANVTLKYGAPVTFGVLTTDSIEQAIERAGTKVGNKGFEAMASLIELINLYRKIGA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: FCTA_RHOPT
Sequence: MTKALDGVRVLDFTHVQSGPTCTQLLAWFGADVIKVERPGSGDITRGQLQDIPKVDSLYFTMLNHNKRSITLDTKNPKGKEVLTALIRTCDVLVENFGPGVLDRMGFTWEKIQEINPRMIVASIKGFGPGPYEDCKVYENVAQCTGGAASTTGFREGLPLVTGAQIGDSGTGLHLALGIVTALYQRHHTGRGQRVTAAMQDGVLNLCRVKLRDQQRLDHGPLKEYSQFGEGIPFGDAVPRAGNDSGGGQPGRILKCKGWEQDPNAYIYVITQAPVWEKICDVIGETGWKMHPDYATPPARLSRLNEIFARIEQWTMTKTKFEAMEILNADDIPCGPILSMKELAEDQSLRATGTIVEVDHPTRGKYLSVGNPIKLSDSPTEVKRSPLLGEHTDEILRDVLGYSDAHVAEIHDSGATAPPRKQAAE
What is the function of this protein?
Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR).  Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate (By similarity).
What are the official names of this protein?
Formyl-CoA:oxalate CoA-transferase, FCOCT, Formyl-coenzyme A transferase, Formyl-CoA transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. Frc subfamily.
Protein: RL31A_YEAST
Sequence: MAGLKDVVTREYTINLHKRLHGVSFKKRAPRAVKEIKKFAKLHMGTDDVRLAPELNQAIWKRGVKGVEYRLRLRISRKRNEEEDAKNPLFSYVEPVLVASAKGLQTVVVEEDA
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L31-A, L34, Large ribosomal subunit protein eL31-A, YL28.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL31 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDD1_HUMAN
Sequence: MTVGARLRSKAESSLLRRGPRGRGRTEGDEEAAAILEHLEYADEAEAAAESGTSAADERGPGTRGARRVHFALLPERYEPLEEPAPSEQPRKRYRRKLKKYGKNVGKVIIKGCRYVVIGLQGFAAAYSAPFAVATSVVSFVR
What is the function of this protein?
Regulates drug efflux through modulation of ABCB1 localization and activity.
What are the official names of this protein?
Required for drug-induced death protein 1.
Protein: Y1720_HAEIN
Sequence: MICTPKVGLNNQLTKVQFFMTKYNFLFKQQVIEFYLQNDKNSSLTRRHFQLAETTLERWINQFNHSGINGLALLGKKRNYSPEFKLNVIQAVKNGKFSAEAACLHFGIANSGVVSQWLQAFEKQGINGLIPKPKGRPTMKLQYPKMPPKPKTREEELELENLRLRAENAILKKLQELNQQKMQKKPLS
What are the official names of this protein?
Uncharacterized protein HI_1720.
What is the protein family that this protein belongs to?
Belongs to the IS150/IS1296 orfA family.
Protein: NRDH_ECOLI
Sequence: MRITIYTRNDCVQCHATKRAMENRGFDFEMINVDRVPEAAEALRAQGFRQLPVVIAGDLSWSGFRPDMINRLHPAPHAASA
What is the function of this protein?
Electron transport system for the ribonucleotide reductase system NrdEF.
What are the official names of this protein?
Glutaredoxin-like protein NrdH.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
Protein: PTH_MYCLB
Sequence: MAEPTLASGWYPRLVVGLGNPGKNYGRTRHNVGFMVANLLAVRLGSKFEVHKRSGADVVNGRLAGCSMLVAKPRNYMNESGQQVGLLAKLYSVTPADIIIVHDDLDLDFGRIRLKLGGGEGGHNGLRSVAAALGTKDFQRVRIGIGRPTGRKDPASFVLENFTTAERMQVPTICKRAADATELLVGLGLEPAQNHVHAW
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_SOLUE
Sequence: MNTTVKRIDPASLNLKEQVVAINRVTKVVKGGKNLSFSALVVIGDPSAKVVGYGVGKAKEVPSAIRKGIEAAKKNLRRINSLDTTIPHQVLGVFASSQVLLKPASPGTGVIAGGAVRAVITACGVPNVLTKSIGRRNPHNVVKATIVALEMLRDRNTVAEMRGLAVEKL
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: HIG2A_MOUSE
Sequence: MAAPGPVSPEAPFDPSKPPVIEGFSPTVYSNPEGFKEKFIRKTRENPMVPIGCLGTAAALTYGLYCFHRGQSHRSQLMMRTRIAAQGFTVVAILLGLAASAMKSQA
What is the function of this protein?
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water.  May be involved in cytochrome c oxidase activity.  May play a role in the assembly of respiratory supercomplexes (By similarity).
What are the official names of this protein?
HIG1 domain family member 2A.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane.
Protein: GLIP1_ARATH
Sequence: MENSQLVSITFLAYTIIISIGSINCIDNNNLVTNQSALFVFGDSVFDAGNNNYIDTLSSVRSNYWPYGQTTFKSPTGRVSDGRLIPDFIAEYAWLPLIPPNLQPFNGNSQFAYGVNFASGGAGALVGTFSGLVINLRTQLNNFKKVEEMLRSKLGDAEGKRVISRAVYLFHIGLNDYQYPFTTNSSLFQSISNEKYVDYVVGNMTDVFKEVYNLGGRKFGILNTGPYDCAPASLVIDQTKIRSCFQPVTELINMHNEKLLNGLRRLNHELSGFKYALHDYHTSLSERMNDPSKYGFKEGKKACCGSGPLRGINTCGGRMGLSQSYELCENVTDYLFFDPFHLTEKANRQIAELIWSGPTNITGPYNLKALFELN
What is the function of this protein?
Confers resistance to the necrotrophic fungus Alternaria brassicicola.  Possesses lipase and antimicrobial activities that directly disrupt fungal spore integrity.  Triggers systemic resistance, mostly by the ethylene-dependent pathway.
What are the official names of this protein?
GDSL esterase/lipase 1, Extracellular lipase 1.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted upon salicylic acid treatment.
Protein: PHEA_SYNY1
Sequence: MKSVITTVVAAADAAGRFPSTSDLESVQGSIQRAAARLEAAEKLAANLDAVAKEAYDAAIKKYSYLNNAGEANSTDTFKAKCLRDIKHYLRLINYSLVVGGTGPLDEWGIAGQREVYRTLGLPTAPYVEALSFARNRGCSPRDLSAQALTEYNSLLDYVINSLS
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex.
What are the official names of this protein?
C-phycoerythrin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Forms the periphery of the phycobilisome rod.
Protein: RPPH_BURPS
Sequence: MLDREGFRPNVGIILLNAHNEVFWGKRLREHSWQFPQGGIKYGETPMQAMYRELHEETGLLPEHVKIIGRTRDWLRYEVPDKFIKREVRGHYRGQKQIWFLLRMVGRDCDICLRATDHPEFDAWRWNEYWVPLDAVIEFKRDVYQLALTELSRFLRRPAQRTDKSRGPRAPRYPRVANGHAASEAPAAIDTSAVCSEVEPGANALDETPPRVSLRD
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: CISY1_YEAST
Sequence: MSAILSTTSKSFLSRGSTRQCQNMQKALFALLNARHYSSASEQTLKERFAEIIPAKAEEIKKFKKEHGKTVIGEVLLEQAYGGMRGIKGLVWEGSVLDPEEGIRFRGRTIPEIQRELPKAEGSTEPLPEALFWLLLTGEIPTDAQVKALSADLAARSEIPEHVIQLLDSLPKDLHPMAQFSIAVTALESESKFAKAYAQGVSKKEYWSYTFEDSLDLLGKLPVIASKIYRNVFKDGKITSTDPNADYGKNLAQLLGYENKDFIDLMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPYLSLAAGLNGLAGPLHGRANQEVLEWLFKLREEVKGDYSKETIEKYLWDTLNAGRVVPGYGHAVLRKTDPRYTAQREFALKHFPDYELFKLVSTIYEVAPGVLTKHGKTKNPWPNVDSHSGVLLQYYGLTEASFYTVLFGVARAIGVLPQLIIDRAVGAPIERPKSFSTEKYKELVKKIESKN
What is the function of this protein?
Specific citrate synthase with catalytic activity only with acetyl-CoA.
What are the official names of this protein?
Citrate synthase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: URK_CROS8
Sequence: MTDKSHQCVIIGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHNLLFQHLQMLKAGKPIELPVYSYVEHTRTAQTVHIEPKKVIILEGILLLTDARLREEMNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMTQYQKTVRPMFLQFIDPSKQYADIIVPRGGKNRIAIDILKAKISQFFE
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMAD3_MOUSE
Sequence: MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
What is the function of this protein?
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.  Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription.  Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription.  Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes.  This effect on wound healing appears to be hormone-sensitive.  Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures.  Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
What are the official names of this protein?
Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, mMad3, SMAD family member 3, SMAD 3, Smad3.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
Protein: CJST_CONGE
Sequence: MTSVQSVTCCCLLWLMLSVQPITPGSPGPAQLSRERSFKFLSGGFKEIVCHRYCAKGIAKEFCNCPDKRDVVSPRIRRRKRSKAM
What is the function of this protein?
Causes scratching in mice.
What are the official names of this protein?
Scratcher peptide.
What is the protein family that this protein belongs to?
Belongs to the conotoxin J superfamily.
Protein: PYRE_NEUCR
Sequence: MAALSPYKADFLKASIDGGVLKFGSFELKSKRISPYFFNAGDFYRADLLQAISTAYAKCIIEAHKSGQLDFDIVFGPAYKGIPLATAATDKLAQLDPETYGKICYSFDRKEAKDHGEGGNIVGAPLKGKRILIVDDVITAGTAKREAIAKIEKEGGIVAGIVVALDRMEKLPAADGDDSKPGPSAMGELRKEYGIPIFAILTLDDIIEGMRGLASPEDVEKTEEYRAKYKATD
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: BLCAP_MOUSE
Sequence: MYCLQWLLPVLLIPKPLNPALWFSHSMFMGFYLLSFLLERKPCTICALVFLAALFLICYSCWGNCFLYHCSDSPLPESAHDPGVVGT
What is the function of this protein?
May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.
What are the official names of this protein?
Bladder cancer-associated protein, Bladder cancer 10 kDa protein, Bc10.
What is the protein family that this protein belongs to?
Belongs to the BLCAP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: O164_CONTE
Sequence: MKLTCVVIVAVLFLTAWTFVTAVPHSSNALENLYLKARHEMENPEASKLNTRYDCEPPGNFCGMIKIGPPCCSGWCFFACA
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-conotoxin-like TxO4, Conotoxin TxMKLT1-0221.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GSTMU_RABIT
Sequence: MPMTLGYWDVRGLALPIRMLLEYTDTSYEEKKYTMGDAPNYDQSKWLSEKFTLGLDFPNLPYLIDGTHKLTQSNAILRYLARKHGLCGETEEERIRVDILENQLMDNRFQLVNVCYSPDFEKLKPEYLKGLPEKLQLYSQFLGSLPWFAGDKITFADFLVYDVLDQNRIFVPGCLDAFPNLKDFHVRFEGLPKISAYMKSSRFIRVPVFLKKATWTGI
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase Mu 1, GST Mu I, GST class-mu.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Mu family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCED2_ARATH
Sequence: MVSLLTMPMSGGIKTWPQAQIDLGFRPIKRQPKVIKCTVQIDVTELTKKRQLFTPRTTATPPQHNPLRLNIFQKAAAIAIDAAERALISHEQDSPLPKTADPRVQIAGNYSPVPESSVRRNLTVEGTIPDCIDGVYIRNGANPMFEPTAGHHLFDGDGMVHAVKITNGSASYACRFTKTERLVQEKRLGRPVFPKAIGELHGHSGIARLMLFYARGLCGLINNQNGVGVANAGLVYFNNRLLAMSEDDLPYQLKITQTGDLQTVGRYDFDGQLKSAMIAHPKLDPVTKELHALSYDVVKKPYLKYFRFSPDGVKSPELEIPLETPTMIHDFAITENFVVIPDQQVVFKLGEMISGKSPVVFDGEKVSRLGIMPKDATEASQIIWVNSPETFCFHLWNAWESPETEEIVVIGSCMSPADSIFNERDESLRSVLSEIRINLRTRKTTRRSLLVNEDVNLEIGMVNRNRLGRKTRFAFLAIAYPWPKVSGFAKVDLCTGEMKKYIYGGEKYGGEPFFLPGNSGNGEENEDDGYIFCHVHDEETKTSELQIINAVNLKLEATIKLPSRVPYGFHGTFVDSNELVDQL
What is the function of this protein?
Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity.  Catalyzes the first step of abscisic-acid biosynthesis from carotenoids.
What are the official names of this protein?
9-cis-epoxycarotenoid dioxygenase NCED2, chloroplastic, AtNCED2.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Note=Partially bound to the thylakoid.
Protein: VP07_BPAPS
Sequence: MLKLKLLTSLAVFTTLLFSCGASYALSSCSPGVIKYIRYETDNAKTLVIIKLDSMNNENYTDNPRLLQPLTYAYAVGEKVTLHTESCTSGDHGFASFSLRNK
What are the official names of this protein?
Putative protein p7.
Protein: HBB1_PANLE
Sequence: SFLSAEEKGLVNGLWSKVNVDEVGGEALGRLLVVYPWTQRFFQSFGDLSSADAIMSNAKVKAHGKKVLNSFSDGLKNIDDLKGAFAKLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGHEFNPQVQAAFQKVVAGVASALAHRYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1, Beta-1-globin, Hemoglobin beta-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: HEMH_XENLA
Sequence: MAAFRAAHRLLGHILRNESSAGLVTQRWSSSAAVASVPKSSDPKPHAQPDKRKPKTGILMLNMGGPETLDDVHGFLLRLFLDKDLMTLPAQSKLAPFIAKRRTPKIQEQYSKIGGGSPIKKWTEQQGEGMVKLLDELSPATAPHKYYIGFRYVRPLTEAAIEEMERDGVERAIAFTQYPQYSCSTTGSSLNAIYRYYNAKGTQPKMKWSVIDRWPTHPLLIQCFADHIQKELNMFPADKRGEVVILFSAHSLPMSVVNRGDPYPQEVGATVQKVMERLGFSNPYRLVWQSKVGPMAWLGPQTDESIKGLCQRGKKNILLVPIAFTSDHIETLYELDIEYAQVLAKECGVENIRRSESLNGNPLFSKALADLVLSHMKSSEICSKQLSLRCPMCVNPVCGEAKSFFTKQQQQ
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, mitochondrial, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: BRCC3_RAT
Sequence: MAVPVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDVRSESKFAHAGSDVCTVPEKVDSIRVVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSVQAQKSSDYERIEIPVHVVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLRELQREKEELMAELRSLE
What is the function of this protein?
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains.  Does not have activity toward 'Lys-48'-linked polyubiquitin chains.  Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs).  Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.  Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (By similarity).  Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity).  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (By similarity).  Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity).
What are the official names of this protein?
Lys-63-specific deubiquitinase BRCC36, BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRISC complex subunit BRCC36.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. BRCC36 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Interaction with ABRAXAS2 retains BRCC3 in the cytoplasm.
Protein: YBEY_ZYMMO
Sequence: MITVEADISDLWPEQSNWEALAQTACQQAVSVSASDFLLAKDYETEISVCFSDNDTVHALNKTWRDKDRPTNVLSFPMMEAEELAEIKNRVGSECLLGDIILAFDVAKKEALEKGISLENHVTHLITHGTLHLLGYDHILDNEAEIMEDLERKALAQLDIPDPYSDHETGKEGLDG
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIMKA_DICDI
Sequence: MDTNNCGVCKTIVNPGSERVKAGTSVFHAKCFVCKECKNELESFIRSKDGSLICDECDIKLNARKCFKCQLPIQSTIVTARGKSFHNDCFNCASCEKIIKGGFFFVEGEFYCSTCDAKPSDKTKTTTPPPSEIPLPGKSGVSLANGVEIQVPNNSTNIIYVLNTNESSNGLSSSGGSGNSISGSGGTNTGSSTSSFMIHKRNNSNELNVVTPTATTTVDLLTSSTTTTPTLSPSTLSPPISTARFSNDYLISLQDDIYAKQQQQLLLLQQQQIQIQQQLQQQQLEILQKNQSLLNSSSPSPSTSSTSSTSSISQSQNLNTSQPNITQQLSNLNISNQKNGEIEKYIPKINGKTLTELLKHQSFDDILGEVLSKKISIYKELSKEEVAFGDVIASGASGKVYKGIYKGRDVAIKVYSSENFCFNIEEFDREVTIMSLIDSDHPNFTRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKEKPLAYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKQMTLNLGTSCYMSPELFKGNGYDETCDVYAFGIVLWEIIARKEPYENINSWSIPVLVAKGERPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDTLKKISESLTLKRNKK
What are the official names of this protein?
Probable LIM domain-containing serine/threonine-protein kinase DDB_G0287001.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Protein: RL21_ALKCK
Sequence: MYAIIETGGKQIKVEEGQEIYVEKLDAEAGEEVSFDKVLFVGGESAKVGAPFVEGASVTGTVEKHGRNKKIIVYKMKAKKNYRRKQGHRQPYTKVVIGKING
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: FTHS_CLOPS
Sequence: MKNDIEIAQSAKMEPIINIAKKIGLEEDDIELYGKYKCKISLDVIKRLENNKDGKLVLVTAINPTPAGEGKSTVTVGLGQALNKIGKNTVIALREPSLGPVFGIKGGAAGGGYAQVVPMEDINLHFTGDMHAITSANNLLCAAIDNHIHQGNLLRIDSRRIVFKRVMDMNDRALRNIVVGMGGKINGFLREDGFMITVASEIMAILCMASDLEDLKERMGNILIAYNLDGEPVYAKELEIEGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSIIATKTALKMSDITITEAGFGADLGAEKFLDIKCRYGNLNPDCVVLVATIRALKHHGGVKKDELNISNVDALNKGMKNLEKQIENIKAYGVPVVVAINKFITDSDEEVKAIEDFCKNIGVEVSLTEVWEKGGEGGIDLANKVIKTMENEPSNFKMIYDSEESIKDKILKIVQTIYGGKGVNYTPQALKQIAEIEKFNLDKLPICMAKTQYSLSDNPSLLGRPENFDITIKEVRVSNGAGFIVVLTGDVMTMPGLPKVPAANRMDIKDNGEIVGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: XPT_HALH5
Sequence: MESLKQAIRERGNVLSDTVLKVDSFLNHQVDPKLINEIGQAFAERFKNEGITKVLTIESSGIAPSLVVATHLGVPFIFARKKKPLTMTDNVYRSQVYSFTKQETNEITVSKDLLHADDRVLIIDDFLANGQAAFGLCEIVEQAGAQVVGFGIVIEKSFQDGRKKLTDKGYRVESLARIQSFKNGTVQFVDEFVTQLSK
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.