PharMolix/UniProtQA huggingface dataset:
Protein: PNP_RHOPT
Sequence: MFNIHSVEIDWGGRPLKLETGKVARQADGAVVATYGETVVLATVVAAKSPREGVDFLPLTVDYQEKAYAAGRIPGGYFKREGRPTEKETLVSRLIDRPIRPLFADGWRNETQVIVTVLSHDMENDPDVLAMVAASAALTLSGVPFKGPIGAARVGFINDEYVLNPVLDEMAETQLELVVAGTADAVLMVESEAKELSEEIMLGAVMFGHRHFQPVIDAIIDLAEKAAKEPRELTVVDDSEIEKEMLGLVEQELRAAYAIPVKQDRYAAVGKVKEKAIAHFFPEGQEPKYDKLRIAGVFKELEAKIVRWNILDTGKRIDGRDSKTVRNILAQVGVLPRTHGSALFTRGETQALVVTTLGTGEDEQYVDSLSGTYKETFLLHYNFPPYSVGETGRLGGTKRREIGHGKLAWRAIHPVLPPHHEFPYTIRVVSEITESNGSSSMASVCGASLALMDAGVPLKRPTAGIAMGLILEGERFAVLSDILGDEDHLGDMDFKVAGTEQGITSLQMDIKIAGITEEIMKVALGQAKDGRIHILGEMSKALDRARAELGEHAPRIETFKIPTDKIREVIGTGGKVIREIVEKTGAKVNIEDDGTVKVASSDGESIKAAIKWIKSIASDPEIGEIYEGTVVKVMEFGAFVNFFGAKDGLVHISQLAAGRVQKTSDVVKEGDKVKVKLLGFDDRGKTRLSMKVVDQTTGEDLEAKQKAEAKAEGEAPAQAAGE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEP1_ARTOT
Sequence: MHGLLLAAGLISLPLHVLAHPQPSSTSLAGRAVDLNEYRIGHRSSYTSNDEMMKQPSIASFRAGTYVEVATEMVKQTMPNMEFRLVDDHYIGQSGIGHVRFRQTMHGIDIDNSDFNVNIGQDGKVLSHGNSFYTGPAPESSPVQKRDFSDPMQALHGVRKALNLPIKAEGATVENMSEHKVMFKGTSGALSDPTAKLCYMAKEDGSLALTWRVETDIGDNWLLSYMDAKDTGKVHNVVDYVAHATFQVYKWGLADPTEGNREILTNPWNLQTSPLTWLADGQNNFTATRGNNAIAQYNPDGGNDYENNYRPSPKNLKFEYPYSANMDPPKTYIDASVTQLFYTSNVCHDLYYMLGFNEKAGNFQVNNRGQGGKGNDYVILNAQDGSGTNNANFATPPDGQPGRMRAYIWTRANPPRDASFEAGTIIHEYTHGLSNRLCGGPANSRCLNAIESGGMGEGWGDFYATAVRLKPKDTRKTNYVKGGWVNNSPKGVRMYPYSTDMSVNPLVYTSNNQLNEVHAIGTVWATMLYELLWNLIDKHGKNDGPVPIFKNGIPSDGKYLAMKIVMDGMAIQPCNPNFVQARDAILDADKNLTKASNKCEIWKAFAKRGLGVGAKFDPKNRIGSNEVPKECK
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 1, Fungalysin MEP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PGPS1_SCHPO
Sequence: MDEGIEKNIFVNLESQIDGVCPKFYVNVDDIDIIHEPPEFYQRLKKLIKKAQKRIFLSTLYIGKEERELINCLSNALSNNPSLHVHILADQLRCTRESPGCCSASLLMQLKKKFPDRCEIKLYHTPNLRGLRKQLVPHRFNEGWGLQHMKIYGADDNLIISGANLSRDYFTNRKDRYYLFSDKGLADFFFKTHFLFSQLSFECIPHLSDSSIQLSSTSPVIPFTLKWNNSCPNPLTNPQEFRVAASAKIQQLLQGNREKFLSRNPSKPLSSVYGSELINQAGDDNNKPFHKYEESAIVYPLFQCVPILTSDVHSTEEKVLSIIGTLLSRKEVNWTLTAGYFNVYPALRKQLLKSEGIGEVIVASQQANGFYRSPGPSKLIPPAYQYIAEQFLKDSRKKKRNIDVLQWQNKGNTYHAKGFWLSTQHHKHPFLTTIGSSNYTSRSQQLDLESTLVVMTQNEKLKRKFSTEIELIKQHTKPMNTCQLEKVPMYVKALTSLMKKKL
What is the function of this protein?
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
What are the official names of this protein?
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, Phosphatidylglycerophosphate synthase, PGP synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PSUG1_PHOLL
Sequence: MNISNKVPFKFSLEVKEALESGKPVVALESNVITHGLDYPDNVTTAKNVEQAVRESGAIPATIGIDKGEFLIGMSDEQIEKFATASHVPKVTSRDIPVVLASGGMGATTVASSILAAEIAGIKFFCSAGIGGVHRGAETSMDISADLTQLTRSRVAVVCAGAKNILDIGLTLEFLETWNVPVISYQSDDFPAFYCRSSGFKSPQRLDELAVIAKAIEINWMLPGGKGVLITTPTKPEDALDNQKIDIIIQEAVLEAKKKNIVGNSLTKYLMRMVDRETDGISAKANMAVLVNTAEVAGKLAVAACLQSSTFFARIKSQ
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase 1, PsiMP glycosidase 1.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: NOC_GEOSW
Sequence: MKHPFSRFFSFGEKEQEETMEKQEKEEVRKIPVSKIVPNRFQPRTIFDEEKIEELALTIHTHGIIQPIVVRECEDGKFEIIAGERRWRAVQKLGWSEIPAIIKNLNDKETASVALIENLQREELTPIEEAMAYAKLLELHNLTQEALAQRLGKGQSTIANKLRLLKLPQEVQEALLHRTITERHARALIVLKDKEKQLKLLQEIIDKQLNVKQTEDRVLKMLEAANPKPKPKRKAFSKDMRIAVNTIRQSLTMVANSGVAVDSEEEEFEDYYQITIRIPKK
What is the function of this protein?
Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle.  It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage.
What are the official names of this protein?
Nucleoid occlusion protein, Noc.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DRP35_STAAN
Sequence: MMSQQDLPTLFYSGKSNSAVPIISESELQTITAEPWLEISKKGLQLEGLNFDRQGQLFLLDVFEGNIFKINPETKEIKRPFVSHKANPAAIKIHKDGRLFVCYLGDFKSTGGIFAATENGDNLQDIIEDLSTAYCIDDMVFDSKGGFYFTDFRGYSTNPLGGVYYVSPDFRTVTPIIQNISVANGIALSTDEKVLWVTETTANRLHRIALEDDGVTIQPFGATIPYYFTGHEGPDSCCIDSDDNLYVAMYGQGRVLVFNKRGYPIGQILIPGRDEGHMLRSTHPQFIPGTNQLIICSNDIEMGGGSMLYTVNGFAKGHQSFQFQ
What is the function of this protein?
Exhibits lactonase activity for dihydrocoumarin or 2-coumaranone, although its natural substrate is not known.  Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis.  Contributes to bacitracin resistance.
What are the official names of this protein?
Lactonase drp35.
What is the protein family that this protein belongs to?
Belongs to the SMP-30/CGR1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUXS_STAAR
Sequence: MTKMNVESFNLDHTKVVAPFIRLAGTMEGLNGDVIHKYDIRFKQPNKEHMDMPGLHSLEHLMAENIRNHSDKVVDLSPMGCQTGFYVSFINHDNYDDVLNIVEATLNDVLNATEVPACNEVQCGWAASHSLEGAKTIAQAFLDKRNEWHDVFGTGK
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: GRIK4_MOUSE
Sequence: MPRVSAPLVLLPAWLLMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVRFQLQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFQQIGQWHVAEGLSMDSRLYASNISDSLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEASEVSVCQEMVTELRNIILCQDNIHPRRRRSGGLPPQPPVLEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWDKTTNSSEPE
What is the function of this protein?
Receptor for glutamate.  L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.  The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.  This receptor binds kainate > quisqualate > glutamate >> AMPA (By similarity).
What are the official names of this protein?
Glutamate receptor ionotropic, kainate 4, GluK4.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi- pass membrane protein.
Protein: PSIP1_FELCA
Sequence: MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQASTKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAIDITTPKAARRGRKRKAEKQVETEEAGVVTTAAASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDMVTEEDKSKKKGQEEKQPKKQLKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNSAKTGVTSTSDSEEEGDDQESEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQIIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLDKEQTGSKTLNGGSDAPDSNQAQHNGDSSEESKDKHEASSKKKPSNEERETEISLKDSTLDN
What is the function of this protein?
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis.  Involved in particular in lens epithelial cell gene regulation and stress responses.  May play an important role in lens epithelial to fiber cell terminal differentiation.  May play a protective role during stress-induced apoptosis (By similarity).
What are the official names of this protein?
PC4 and SFRS1-interacting protein, LEDGF/p75, Lens epithelium-derived growth factor, Transcription coactivator p75.
What is the protein family that this protein belongs to?
Belongs to the HDGF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEXA_CALS8
Sequence: MKKQLTKKQEEILEFIKKRIKEKGYPPAVREICEATGLKSTSTVHGHLTRLEKKGYIRRDPSKPRAIEIVDDDFYVHRNVIRLPLVGKVTAGEPILAVENIEDTITLPYDLVGTEDAFLLRVKGDSMIDAGIFDNDIIIVKRQNVAENGDIVVALIDDEATVKRFFKESDHIRLQPENKAMEPIIVKDVKILGKVIGLIRRM
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: FUMC_ECOL6
Sequence: MNTVRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLSEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDRWVRPEQMVGSMKAGG
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP7_ROTB9
Sequence: MYSTECTILLIEIIFYFFAAVVVYDAIHKMANSPIFCIAVLAVVFAVSPKCFAQNYGINVPITGSLDVAVPNKTDDQIGLTSSLCIYYPNEAEIEINDNEWKNTVAQLLLTKGWPTTSVYLNGYADLQSFSNNPQLNCDYNIVLVKYDQNAGLDMSELAELLLYEWLCNEMDVNLYYYQQTSEANKWIAMGSDCTIKVCPLNTQTLGIGCQTTDVATFEQLTATEKLAIIDVVDGVNHKVNYTIATCTLKNCIRLNQRENVAIIQVGGPEIIDVSEDPMIVPKMIRATRINWKKWWQVFYTVVDYINTIIQAMSKRSRSLNTSTYFLRI
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: MDTJ_ECOL6
Sequence: MYIYWILLGLAVATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLFDESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGAV
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtJ.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y115_BUCAP
Sequence: MQNPKEKMDLSQFILSLIFIIAISATSFLIIQPFILGFSWASMIVIATWPLMLKMQKFLGGKRLVAVIGMIIILLLLFIIPIVFLVNSLIKTSIPLIHWFSSNNLEFPELIWLQDIPIIGKKIFISYQELLDSDGGELIREIRPYMGRTTEFFIIQAKNCGLFIMHLTLMLLFSLLLYWNGEKISNSIRQFASRLSSRNGEAIVLLSVQAVRAVALGVVVTALIQAVLSGIGLLISGVPYWTLLMILIVFSCLIQLGPLPILIPSVIWLYWNSNTTWGTLLLIWSCFVFILDNILRPFFIRIGSDLPTFLILLGVIGGLLAFGMIGLFIGPVVLVILYRLIVSWIYGISIASFLENTTLKSKSN
What are the official names of this protein?
Putative transport protein BUsg_115.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSAI_GUITH
Sequence: MTAAYLPSILVPIIGIIFPGLTMAFAFIYIEQDQIN
What is the function of this protein?
May help in the organization of the PsaL subunit.
What are the official names of this protein?
Photosystem I reaction center subunit VIII, PSI-I.
What is the protein family that this protein belongs to?
Belongs to the PsaI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DNLJ_BRASO
Sequence: MAKTAKSKQSVDVADLTKAQAKVEWKRLALELETHDRLYYQEDAPKISDAAYDELRRRFNAIEKRFPELVSRDSPSQTVGAAPSGRFKKVRHAVPMLSLDNAFAEEDVRDFVGRIARFLKLAEDDRIAFSAEPKIDGLSMSLRYEGGQLVTAATRGDGAEGEDVTANIRTLKDVPQKLHGRNLPDICEIRGEVYMTKQAFLALNERQKEAGDTIFANPRNSAAGSLRQKDPTITASRPLGFFAYAWGDMSAMPAETQSGMIKWFEHCGFTTNPLTKLCHSVEELIAFHRAIEEQRAELDYDIDGVVYKVDRIDWQERLGFVSRTPRWGIAHKFPAERAMTVLKDIEIQVGRTGSFTPVGKLEPVGVGGVIVQNVTLHNEDYIKGIGNKGEVLREGRDIRIGDTVVIQRAGDVIPQVVDVLIDKRPADAEVFAFPRKCPCPLHTDVVREETAAGEEGSRARCTGEFACPYQKIEHLKLFASRRAFDIDGLGEKQIQFFFDEGWVKEPADIFTLQKRNAKLKLEEVEGYGETSVRNLFNAIEARREMALERFIYALGMRYVGETTALALARGYGSWEAFHDACLKVANGDEEAIAEMDALDQIGETVIKSVAAYFGEDHNRGIVERLTREVKILDAEKPKRNSPIATKTVVFTGTLEKMTRDEAKATAERLGAKVSGSVSKKTDYVVAGPGAGSKLKDAEKHGVKVLTEDEWLQLIGE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: HUNB_DROAD
Sequence: WYSSMFAANIKQEPISHHHHHHHAHHSRRQHPHDSNSNSNASSPHQSPLPSPNPPSNTNLQLEQYLKHQQQQQQQQHQQQPMDTLCAAAMTPSPSNNDQNSPLTWPGLPNPMQSIMPANLRPSPNTTTTTPPAAAPAAATIALQANDKLQALTPPMDVTPPKSPAKSQQSCAEPEKEHDLMSNSSEDMKYMA
What is the function of this protein?
Gap class segmentation protein that controls development of head structures.
What are the official names of this protein?
Protein hunchback.
What is the protein family that this protein belongs to?
Belongs to the hunchback C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NORA_STAAS
Sequence: MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSLGLSAFETLYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVVIVLIEKQHRAKLKEQNM
What is the function of this protein?
Involved in quinolone resistance.  May constitute a membrane-associated active efflux pump of hydrophilic quinolones (By similarity).
What are the official names of this protein?
Quinolone resistance protein NorA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACKA1_VIBCH
Sequence: MSKLVLVLNCGSSSLKFAVVDAQSGEQHLSGLAECLHLPEARIKWKLDGKHEAQLGEGAAHDEALSFIVETILASKPELAAQLKAIGHRVVHGGEQFTQSALIDDAVLKGIEDCAALAPLHNPAHIIGIKAAQKAFPELKNVAVFDTAFHQTMPEEAYLYALPYNLYKEHGIRRYGMHGTSHLFIAREAAERLGKPANELNIINCHLGNGASVCAIKNGQSVDTSMGLTPLEGLVMGTRCGDIDPAIIFHLHDTLGYSVEKINTMLTKESGLLGLTEVTSDCRFVEDNYGQKEEATRAMDVFCHRLAKYVAGYTASLDGRLDAITFTGGIGENSAPIREMVLNRLAIFGITVDSAANLKARFGGEGVITTADSRIPAMVIATNEELVIAEDTARLTNI
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase 1, Acetokinase 1.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUD_THET2
Sequence: MDLVFRPERYPFLTQDLPGVGGEIRVEPEDFQVEEVPAYLPKGEGEHLYFLLEKEGRTTREVLEFLRDEVGVPEKEIGVAGLKDKRAKTRQWFSIPRKYEDALCLLENLQGVRLLAADLHTNKLRTGHLKGNRFHILIRRPKGGVAEAEAVLKRLAEKGVPNYYGPQRFGLGGLNPVRGYKLVKEGKGRGSPWLKRFLIGSLQSLLFNDWVALRMALGLYDRVVLGDWAKKHATGGEFLVEDPGEAERALRLEISATGPLFGKKYPEAQGEARAIEDEVLARYGLKREEFRARRGARRPIRVPLAEWKVEEAPEGLWLSFFLPKGSYATSLLREVMKVEALDHLEAEPAPEDAEGL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: HTPG_PORG3
Sequence: MSKKGTIGVTSDNIFPVIKKFLYSDHKIFLREIVSNAVDATQKLKTLTSVGEFKGETGDLRVTVSVDEVARTITVSDRGVGMTEEEVEKYINQIAFSSAEEFLEKYKDDKAAIIGHFGLGFYSAFMVSERVDVITRSFREDATAVKWSCDGSPEYTLEPADKADRGTDIVMHIDEENSEFLKKEKIEGLLGKYCKFLTVPIIFGKKQEWKDGKMQDTDEDNQINDTHPAWTKKPADLKDEDYKEFYRSLYPMSEEPLFWIHLNVDYPFNLTGILYFPKIKNNLDLQRNKIQLYCNQVYVTDEVQGIVPDFLTLLHGVIDSPDIPLNVSRSYLQSDANVKKISSHITKKVADRLEEIFKNDRPTFEEKWDSLKLFVEYGMLTDEKFYERAAKFFLFTDMDGHKYTFDEYRTLVEGVQTDKDGQVVYLYATDKHGQYSHVKRASDKGYSVMLLDGQLDPHIVSLLEQKLEKTHFVRVDSDTINNLIRKEERAEVKLSDTERATLVKLFEARLPRDEKKHFNVAFESLGAEGEAILITQAEFMRRMRDMAQLQPGMSFYGELPDSYNLVLNTDHPLIDKVLSGEKESVEPSLTELRAKIAELKTEEAKLLDEEKGKKPEEIPVATKEAKENNAVEQAKTEGSINDQLTKYAQDNELIGQLIDLALLGSGLLTGEALAEFIRRSQRLL
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_SYNC1
Sequence: MGIKIIANNKKAYHDYFIDEVLEAGMVLLGTEVKSLRLGKANLKDAFCRIMGGELYVNNLHISPYEFGNRENADPTRARKLLVHRAELDKLARKVDEKGLSLVPTKLYFKEGRVKIEIGIARGKKLHDKRQTLKSKEADREMARALRDRH
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RS17_XYLFT
Sequence: MMNDNNERKPLRTIKGLVISNKMQKTVTVLVERQIKHALYGKYIKRSTKLHAHDADDLCNEGDVVLMTEVAPISKTKNWRVVEIVARSD
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: TF2H2_DICDI
Sequence: MSKNIYNNNAQNKRTNRSLYDDEDGPAHVLQTNDEDGTNKYKWENRFEKTWLTIDEDEHGLRPSNQEERNTRNRRLKNKDRDGILSQDQRVRRGMQRHLCLILDLSKTLSNQDLKPSRYQVLLQNVELFIKEFFDQNPISQLSIIITKNSKAEKISELSGNRLRHIQAMKDAIAMEGEPSIQNSLEVALSSLCYVPKYGSREVLFIFSSLTTCDPSSLQKTIQSLKNESIRVSFIHMAAELYICKAIAEQTNGTSKVILNEEHFNESLMLKCQPPPTIGKTEAALVEMGFPQQITSTVPSPCICHEKMKYSGYICPRCGVKSCELPTDCQICNLSLVSSPHLARSYHHLFQIPLFNEVNWKELNKNVTCIGCLSSSEKSILSLFFSCPRCQEIFCLDCDLFIHESLHNCPGCENKLQNTNTNTNGKTNGNEITNGNGNGNGNENENGNGNGNGNGNGNGLH
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
What are the official names of this protein?
General transcription factor IIH subunit 2, TFIIH basal transcription factor complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GTF2H2 family.
What are the subcellular locations of this protein?
Nucleus.