PharMolix/UniProtQA huggingface dataset:
Protein: SEC65_KLULA
Sequence: MPVIEEIDDIDDIDNLEMDLAELDSTMKTPVAPKIVPTVVRSQDQEEEAYSAAISGNAGSGSGFNFVNSTTGQVEKSHSLTKEELDEIKEFQMLYPCYFDTRRTHAQGRRAPKDLCVENPLAKTIADAARSLGIPSIFEGSKTHPQDFGNPGRVRVLIKENGKPFVSGIDNKRVLMKRIGEYLKSHPTTLESVKQLPYGPDFDNVEPKKIPLLKGTAMNDIVPLHSPYLTQHPMTKSLYDAPPPPPPAQQVSAPEKQMKMPKNKFRVVRR
What is the function of this protein?
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane.  It must be involved intimately in the translocation of a wide variety of protein substrates (By similarity).
What are the official names of this protein?
Signal recognition particle SEC65 subunit.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFB_YERPY
Sequence: MTKSELIERLAGQQSHVPAKVVEDAVKEMLEHMAGTLAEGERIEIRGFGSFSLHYRAPRVGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: SPY_ORYSJ
Sequence: MGRPGMDSSEGRESNGVVPERNGGAVPAKQQLDGKDTLRYANILRSRNKFAEALQLYNNVLEKDEANVEALIGKGICLQAQSLPMQAIECFNEAVRIDPGNACALTYCGMIYKDEGHLVEAAEAYQKARNADPSYKPAAEFLAIVLTDLGTSLKLAGNTEEGIQKYCEALEVDSHYAPAYYNLGVVYSEMMQFDLALTCYEKAALERPLYAEAYCNMGVIYKNRGELEAAIACYERCLTISPNFEIAKNNMAIALTDLGTKVKIEGDINQGVAYYKKALFYNWHYADAMYNLGVAYGEMLNFEMAIVFYELALHFNPRCAEACNNLGVIYKDRDNLDKAVECYQMALSIKPNFSQSLNNLGVVYTVQGKMDAASSMIQKAIFANSTYAEAYNNLGVLYRDAGSITSAVQAYEKCLQIDPDSRNAGQNRLLALNYIDEGFDDKLYQAHREWGKRFLKLYPQYTSWDNPKVADRPLVIGYVSPDYFTHSVSYFIEAPLAHHDYSNYKVVVYSGVVKADAKTLRFKDKVLKKGGLWRDIYGIDEKKVASLVREDKVDILVELTGHTANNKLGTMACRPAPIQVTWIGYPNTTGLPTIDYRITDSLADPPDTTQKHVEELVRLPESFLCYSPSPEAGPVCPTPAILNGFITFGSFNNLAKITPKVLQVWAKILCAVPNSRLVVKCKPFCCDSIRQKFLSTLAELGLEPLRVDLLPLIHLNHDHMQAYSLMDISLDTFPYAGTTTTCESLYMGVPCVTMAGSVHAHNVGVSLLTKVGLGRLVAKSENEYVSLALDLAADVTALQELRMSLRGLMAKSPVCDGENFTRGLESAYRNMWRRYCDGDAPALRRLDLLQEEPCSNNNKQDFDDNQVAKLADLKAQRVDAAVDGDKQSQLTAHAAVVGEVQQAPIMVNGVSSPVSSGKVEANGHISR
What is the function of this protein?
Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway.  OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine.  Probably acts by adding O-linked sugars to yet unknown proteins (By similarity).
What are the official names of this protein?
Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ODBA_BACSU
Sequence: MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPFVISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNSGGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQGDFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGNDPLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPLLTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK
What is the function of this protein?
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
2-oxoisovalerate dehydrogenase subunit alpha, Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain, BCKDH E1-alpha.
What is the protein family that this protein belongs to?
Belongs to the BCKDHA family.
Protein: GLYA_BAUCH
Sequence: MFKYDINIANYDTALWKAIELEAKRQEEHIELIASENYTSPRVMQAQGSILTNKYAEGYSGKRYYGGCVYVDQVETLAIDRAKALFECDYANVQPHSGSQANFAVYTALLKPGDTILGMNLAHGGHLTHGASVNFSGKMYNVISYGVNKNGYIDYEQLNKLATMHKPKMIIGGFSAYSRVVDWDIMRQVADSIKAFLFVDMAHIAGLVAAGVYPNPVPYADVVTTTTHKTLAGPRGGLILAQGGSKEMYKKLDSAVFPGAQGGPLMHVIAGKAIALKEAMEPEFKIYQHQVVKNAKTMVNVFLNRNFNVVSGGTDNHLFLLDLVDKNITGQEADAALSYTNITVNKNIIPNDPQSSFVTSGIRIGTPAITRRGFNETDAYQLANWICDVLENINNEVVLNATKKKVLNICASHPVYS
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STXB4_MOUSE
Sequence: MSDGTASARSSSPLDRDPAFRVITVTKETGLGLKILGGINRNEGPLVYIHEVIPGGDCYKDGRLKPGDQLVSINKESMIGVSFEEAKSIITRAKLRSESPWEIAFIRQKSYCGHPGNICCPSPQVSEDCGPQTSTFTLLSSPSETLLPKTSSTPQTQDSTFPSCKAIQTKPEHDKTEHSPITSLDNSPADTSNADIAPAWTDDDSGPQGKISLNPSVRLKAEKLEMALNYLGIQPTKEQREALREQVQADSKGTVSFGDFVQVARSLFCLQLDEVNVGVHEIPSILDSQLLPCDSLEADEVGKLRQERNAALEERNVLKEKLLESEKHRKQLIEELQNVKQEAKAVAEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAEVSELKAQLADYSDQNKESVQDLRKRVTVLDCQLRKSEMARKAFKASTERLLGFIEAIQEVLLDSSAPLSTLSERRAVLASQTSLPLLARNGRSFPATLLLESKELVRSVRAILDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSALNLSCAEESEEDCPRELTDPKS
What is the function of this protein?
Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane.  Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2.  Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane.  May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.
What are the official names of this protein?
Syntaxin-binding protein 4, Syntaxin 4-interacting protein, STX4-interacting protein, Synip.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y16B_BPT4
Sequence: MGYTDTRDLREHIFECGVAKKFSFTCKCLREVIQHYEQFSRKA
What are the official names of this protein?
Uncharacterized 5.2 kDa protein in arn-motA intergenic region.
Protein: RS11_BURM9
Sequence: MAKASNTAAQRVRKKVKKNVAEGVVHVHASFNNTIITITDRQGNALAWATSGGQGFKGSRKSTPFAAQVAAESAGRVAMEYGVKNLEVRIKGPGPGRESAVRALHGLGIKITAISDVTPIPHNGCRPPKRRRI
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RECO_ACAM1
Sequence: MSRTYKATGINLKSMPFGEADRLLTILTREQGLVRAVAPGCRKPKSKLGGRSALFVVNDLMLVQGRSLDKIAQAETLESYPGLSQNLAKLTTSQYLAELTLYQALSGQPQTELWDLFCQQLTQLQNATLAQVPCCLIHGTLKLLAGAGIAPQVHACCVTHQPLDPPTSNPTWRVGFSAGAGGTVTLTGPPRPRTAIQQAAEQAIAYPLGADYRVQGKLSAQELALLQDLNPAEIQPASPLPLPLIATYPLVIWQGVESALRHYAEAYFDRPIRSAALIDTCFTPLPDLTSVPS
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RL20_YERPG
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGLSYSRFINGLKKASVEIDRKILADIAVFDKVAFSALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: SYSC_CRIGR
Sequence: MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDEFIPEDVLNFDDLTADTLSALKVSQIKKVRLLIDEAIQKCDGERLKLEAERFENLREIGNLLHPSVPISNDEDADNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYTPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDSSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMIGTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGIIVPEKLREFMPPGLQELIPFVKPAPIDQEPSKKQKKQHEGSKKKAKEVTLESQLQNMEVTEA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser).  Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).  In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC.  Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16).  Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
What are the official names of this protein?
Serine--tRNA ligase, cytoplasmic, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus.
Protein: SECY_SYNY3
Sequence: MVVSRDKAPSAQETFLQMAQAAGLRGRLLITIGLLILVRVGIFIPVPDIDRQAFSQAINDNSVIGFLNIFTGGGLSTVGIFALGILPYINASIIMQLLTAAIPALEDLQKNEGEAGRRKISQYSRYIAFGWCIIQGLGLTVGLLRPYANNYGPLFIFQTVLAITAGSMFVMWISELITERGIGNGASLLIFVNIVATLPQTLGQTIEYAQSGGRQSITAVVLLMLVFLVMIVGIVFVQEGTRRIPIISARRQVGKKLYRERTSYLPLRLNQGGVMPIIFASAVLILPSSLAGFATGNEGLGGFGEIFVQISNALRPGTWVYTVVYSVMIFFFSYFYASLIVNPEDVSKNLKKMGSSIPGIRPGKKTEQYLEGVLNRLTFLGAIFLSFVATLPIFVEQATGVTTFQGLGATSLLILVGVAIDTAKQIQTYVISQRYEGMIKQP
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: RNZ2_SCHPO
Sequence: MKASLLVPRRALLFGQLLPPKYSWYSVKRWQSQLTFRNKSKRNTNRIMLSVVSSLNPDSLIAPLLCVSLDNRKYLIGSMGELTQMKFRSQASNYGGKSVSVFLMPPSLQSLNAWGITAGLFGYLQSSGIQNTWGLHAPKPVISIIKKSHHLFSGSPLRLDLNSFSSEDNADATNSFYLDEPEFCTIKGNIYSNWSFLSFNSKEAAGVFNADKALALGVPFGPSNGKLCAGEAVLSKDGTTWIYPHQVVGPPRKRQYFYVLGCSSLSALNQMSKHVDSFSDVYPTCIIHILEKGIWGPEYIKFLSHPKFSRAQHFISCIELASNNPVFQRNKGRNVLPACRDFAAFDIKPSTLDTQTQLPENTYVLKEETSMVLYDEQCKISESPSYSPVKLAKKFSSFNPLPFENEGYTLDVLGTSATCPTWRRSLSSYSVAIDGTVIMLDCGEGAISQFFRQYGTNTEPMLRKLKAIFITHLHSDHYLGLLNVLQAWNKANTNNSMHINIIGPKFLWQWLQRLKSPANLQALLNRIIFIIAKETVTTPLQLTSDLSISSVPSIHINDSYSCIISHTKYGKLVYSGDTRPNEKLVKAGIGASLLLHESTFEDDLKHEAIQRQHSTASEALSVAQSMKAKALILTHFSQRSYDADFLPPDWTIYPKSKTIYANDGLQWQQFQSKQRETI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  May be involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z 2, mitochondrial, RNase Z 2, tRNA 3 endonuclease 2, tRNase Z 2.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: HLDE_ECO27
Sequence: MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: SYP_ACIAD
Sequence: MRASRFLFATLRETPNDAEVISHQLMLRAGMIRKLASGLYTWLPMGVRVLNKVEAIVREEMNRSGALEVFMPVTQPASLWEESGRYVQYGPELLRFKDRHDNPFVLGPTHEEVITDLARNELKSYKQLPINFYQIQTKFRDEIRPRFGVMRSREFIMKDAYSFHVDQASLQETYDNMYDTYCRIFTRLGLDFRPVQADTGSIGGSGSHEFHVLADSGEDDIVFSTESDYAANVEKAEAVLVGERAAPAQALSIVDTPNQKTIADVCTFLNADPKQSVKALLVQGNADEKGNVPVIALFLRGDHELNEIKAEHHPLIAAPLTFATEAQLQELGLTAGYVGPQGLVEKGLTVIVDRAASVLSDFIAGANEADKHATGVNWERDAKFSEIYDLRNVVDGDPSPDGQGVLQIKRGIEVGHIFQLGQKYSEALNCTVLGDDGKPLVVTMGCYGIGVTRVVASAIEQNYDDKGIIWPSAIAPFEIAIVPMNAHKSPKTLEAAEALYAELQAQGYDVLLDDRNERPGVKFSDLELTGIPHRIVIGEKGLDAGTFEYKGRTDAESVNLTKDELLAKLK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1625_HYPNA
Sequence: MIVIENILGQDVLTEVAAALRELRWEDGRNTAGATARRVKRNQQADLSSRTGSKVREVLLEAVKRHPVVEAYARPLKFAPPLISCSGEGDAYGLHIDNPVMGKGDARLRTDLSFTLFLSPPESYDGGELEIETVFKTESVKLPAGSMVIYPSTELHRVTPVTSGERFVFVGWIQSAIKDAAQRAILFDVTNLKAGLARRFPPGSPELLTLAKTESNLIRMWSDI
What are the official names of this protein?
PKHD-type hydroxylase HNE_1625.
Protein: RNFD_RHOCA
Sequence: MHMPVAGPHTHTLFTVSRTMLTVVAALTPATLFGLWEFGWPAIFLFLTTVVSAWVFEVACLKIADKPIRPFATDGSAILSGWLVAMTLPPYAPWWVGVIGSFIAIVIAKHLFGGLGQNLFNPAMVARAMLVVALPVQMTTWIAPVGLLEGPSFLHGLSITFLGSQEFDAVSSASTLSHIKSQISAGATMGEILPTLADLESRLLGFVPGSLGETSTVLLALGGLLLLVTRIITPTIPLAVLGTLVTLSAICSFLAPDRFAPPILHLTSGSTMLCAFFIATDYVTSPVTTAGKWVYGIGIGTLVFVIPLRRLPRGRGLCGALDELGHAPDRNLHPAADLRTVPHRQAACAAKPAKGAQK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity).  Required for nitrogen fixation.  Involved in electron transfer to nitrogenase (PubMed:8264535).
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Nitrogen fixation protein RnfD, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cellular chromatophore membrane; Multi-pass membrane protein.
Protein: HEM3_LISMC
Sequence: MKRKIIVGSRRSKLALTQSNWVINKLKENYPEFDFEIKEIVTKGDRILDVTLSKVGGKGLFVSEVEQALSDEVIDFAVHSMKDVPSSLKEGLIIGAIPKRESPLDCFVFNRVNSLDELPQGSVIGTSSLRRAAQLLKHRPDFVIKPIRGNIDTRLQKLHAENFDAIILAKAGLARMGWLENTTLKLEDIPPELCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEIPIAGFATRANEVVHFKGLVGNADGSIILASEQAGANPSEIGNKVAEDLLSEGADTIIKELRNI
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: VP14_ALVA
Sequence: MEAVIREGGSLPQVRSASRNQQRSGESTKGRKWEKQLRSEMRRWRRRKWPHLKPLAHPAISAEQLLAVIAPQPRPLLLLMWGVVCILPWRGWESSRARGVTHLGGRNSQGRSQGTRVWPLGRP
What are the official names of this protein?
Putative trans-acting factor.
Protein: AOFB_BOVIN
Sequence: MSSKCDVVVVGGGISGMAAAKLLHDSGLNVIVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNHILRLSKELGLETYKVNEVERLIHHTKGKSYPFRGSFPSVWNPITYLDHNNLWRTMDDMGREIPSDAPWKAPLAEQWDLMTMKELLDKICWTESSKQLAILFVNLCVTAEIHEVSALWFLWYVKQCGGTTRIFSTSNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIHIDQTGENVLVETLNHELYEAKYVISAVPPVLGMKIHFNPPLPMMRNQLITRVPLGSVIKSIVYYKEPFWRNMDYCGSMIIEGEEAPVAYALDDTKPDGSYPAIIGFILAHKARKLARLTKEERLKKLCDLYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTSYFPPGIMTQYGRVLRQPVGRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWLPEPESVDVPAKPITTTFLQRHLPSVPGLLKLIGLTTIFSATALGFLAHKRGLLVRI
What is the function of this protein?
Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:8003474).  Preferentially degrades benzylamine and phenylethylamine (PubMed:8003474).
What are the official names of this protein?
Amine oxidase [flavin-containing] B, Monoamine oxidase type B, MAO-B.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Protein: VP4_ROTBK
Sequence: MASLIYRQLLYNSYSVDLSDEITNIGAEKKENVTVQLGQFAQSQYAPVSWGSGETLSGNVEEQPLDGPYTPDSSNLPSNYWYLVNPSNDGVVFSVTDNSTFWMFTYLVLPNTAQTNVTVNVMNETVNISIDNSGSTYRFVDYIKTSSTQAYGSRNYLNTAHRLQAYRRDGDGNISNYWGADTQGDLRVGTYSHPVPNAVINLNADFSVIPDSQQEICTEYIRGGLPAMQTTTYVTPISYTIRSQRIVRPNEDIVISKASLWKEVQYNRDIVIRFVFANNIIKAGGLGYKWSEISYKANNYQYTYMRDGVEVVAHTIVSVNGVSVYNYNTGPLPTDFMIRNYDVLKESSFVYIDYWDDSQAFRNMVYVRSLSAELNQVRCVGGHSSFALPVGSWPVMQGGSVILTFDGVTLSTQFTDFVSLNSLRFRFRCAVSEPPFRVTGTRISNLYGFPAANPMGDQQYYEASGRFSLISLVPSNDDYQTPIANSVTVRQDLERQLDEMRKEFNELSANIALSQLIDLALLPLDMFSMFSGIQSTVEAAKTFATSVMKKFRKSDLAKSVNSLTDAITDAASSISRSSTLRSANSAVSVWTDISDIVDSTDNVVAATATAAAKKFRVKEFTTEFDGVSFDDISAAVVKTKMNKFNVVDEEILPRIITEASEKFIPNRAYRLIDGEKVYEVTTEGKSFAYLTETFEEVVFDAERFAELVTVSLVISAIIDFKTIKNLNDNYGITREQALNMLRSDPKVLRSFINQNNPIIKNRIEQLILQCRI
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: ATG7_BOTF4
Sequence: MALKFAPFASEIELPFYTALSQLKIDHDKLDDSARPVLGLYEPRATQSPDQSSRMRVLGNALSSNEVPSGHIRAEGKIKNVNTIEDFKNMDKQAMLQTSAKQGQIWDAINDGTIYSIPSLLSSFTILSFANLKKYTFTYWFAFPALHSEPAWRKVEQPPKFSAEETTALTEELGTWRYSHDNREHGFFLAKRVYPSSEHPQDPESESTSDLPFKWVIGSLREFESGFFNGVDAKNQYVSFVDPSTYHENPGWMLRNLLVLVRRRYKLDKVQILCYRDNHAKRHVPQSLILILESIYDPEYQSTAPDQIPKVTGWERNSLGKLTAKVTNLAQYMDPAQLADQAVDLNLKLMKWRIAPELNLDAIKNTKCLLLGAGTLGTYVSRLLMGWGVRKITFVDNASVSFSNPVRQPLFDFKDCIDGGAKKAYRASEALQEIYPGVDSTGHVMAVPMLGHPITDEAATKMNFELLQKLIEDHDAIFLLMDTRESRWLPTVMGKAAGKIVMNAALGFDTYVVMRHGVTPEDGGPAALGCYFCNDVVAPSDLLQSVKDQTLDQQCTVTRPGVAPEASSKLVELLASVLQHPLKGAAPAPKLSSNHQSGQLEFDRDPPNHPLGLVPHQIRGFLAAYKTMLISGPSYDCCSACSPKIVNAYKEDGWEFIKRALTEKDYITELSGLAEVQRKAEAAANDVEWDSDEEGMEDEEPELL
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy (PubMed:29417220).  Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine (By similarity).  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes (By similarity).  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity).  Required for normal mycelial growth and conidiogenesis, and regulates sclerotial formation (PubMed:29417220).  Plays an essential role in pathogenesis (PubMed:29417220).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme atg7, ATG12-activating enzyme E1 atg7, Autophagy-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.