PharMolix/UniProtQA huggingface dataset:
Protein: POLG_LIV31
Sequence: SRCTHLENRDFVTGTQGTTRVTLVLELGGCVTITAEGKPSVDVWLDAIYQESPAKTREYCLHAKLSETKVAARCPTMGPAALAEERQIGTVCKRDQSDRGWGNHCGLFGKGSIVACVKAACEAKKKATGYVYDANKIVYTVKVEPHTGDYVAANETHKGRKTATFTVSSEKTILTLGEYGDVSLLCRVASGVDLAQTIILELDKTAEHLPTAWQVHRDWFNDLALPWKHEGNPHWNNVERLVEFGAPHAVKMDVYNLGDQTGVLLKALAGVPVAHIEGNKYHLKSGHVTCEVGLEKLKMKGLTYTMCDKSKFAWKRTPTDSGHDTVVMEVTFSGSKPCRIPVRAVAHGSPDVNVAMLITPNPTIENDGGGFIEMQLPPGDNIIYVGELSHQWFQTGSSIGRVFQTTRKGIERLTVIGEHAWDFGSAGGFFSSIGKAVHTVLGGAFNSIFGGVGFLPKLLMGVALAWLGLNTRNPTMSMSFLLTGGLVLAMTLGVGA
What is the function of this protein?
Binds to host cell surface receptor and mediates fusion between viral and cellular membranes.  Envelope protein is synthesized in the endoplasmic reticulum in the form of heterodimer with protein prM.  They play a role in virion budding in the ER, and the newly formed immature particle is covered with 60 spikes composed of heterodimer between precursor prM and envelope protein E.  The virion is transported to the Golgi apparatus where the low pH causes dissociation of PrM-E heterodimers and formation of E homodimers.  prM-E cleavage is ineficient, and many virions are only partially matured.  These uncleaved prM would play a role in immune evasion.
What are the official names of this protein?
Genome polyprotein.
What are the subcellular locations of this protein?
[Envelope protein E]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YCF3_CITSI
Sequence: MPRSRINGNFIDKTFSIVANILLRIIPTTVGEKEAFTYYRDGMSAQSEGNYAEALQNYYEAMRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFRALERNPFLPQAFNNMAVICHYRGEQAVRQGDSEIAEAWFNQAAEYWKQAIALTPGNYIQAQNWLKITGRFE
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: NU3M_BAITA
Sequence: MNMIMVISVNIILSSTLILVAFWLPQLNIYTEKANPYECGFDPMSSARLPFSMKFFLVAITFLLFDLEIALLLPIPWAIQMPDMKTMMLTAFILVSILALGLAYEWTQKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: WFD11_MOUSE
Sequence: MKPSWFPCLVFLCMLLLSALGGRKNKYYPGELLLEECWGQPKTNDCVKKCSRTFKCVYRNHTCCWTYCGNICAENGKFFERK
What are the official names of this protein?
Protein WFDC11.
What are the subcellular locations of this protein?
Secreted.
Protein: YQFX_BACSU
Sequence: MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEPYRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRRGAQGLGAWAMGIGVVSLVLGIFIIPFF
What are the official names of this protein?
Uncharacterized protein YqfX.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y074_NPVOP
Sequence: MSDAGEAPAVAATDKPHRRTLRAAQDDYTVDGLRLKPAYVEYYRQLQEIVELAVITLSKQLDIREVQEVYSLARQLYEILRGQFVDEPFKLWLETNASRLAADAEFKKSMHKILQDQLQTLTAKTNTFKNAVLNVLNNELSTDANLYDTSAGYIKPNCIVTTFTCCDLTFEP
What are the official names of this protein?
Uncharacterized 19.5 kDa protein.
Protein: RLMH_YERPA
Sequence: MKLQLVAVGTKMPDWVQTGFIEYLRRFPKDMPFELAEIPAGKRGKNADIKRILEKEGELMLAAVGKNNRIVTLDIPGTPWETPQLAQQLERWKQDGRDVSLLIGGPEGLAPACKAAAEQSWSLSPLTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCY1B_CHRCN
Sequence: DDCLGFFKSCNPDNDKCCENYKCNRRDKWCKYVL
What is the function of this protein?
Voltage-gated sodium channel Nav1. 7/SCN9A inhibitor.
What are the official names of this protein?
Mu-theraphotoxin-CCy1b, Mu-TRTX-CCy1b.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 22 (Htx-4) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NUSB_BACC4
Sequence: MKRRTARERAMQALYQMDITGELEPKVAVENTLDEGEETNEFLESLVVGFVENKEAIDEAIRQNLKKWKLERISIVDRSILRVAVYEMKYMEEIPHNVTINEAIEIAKTFGDEESRRFINGVLSNIKDTL
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: POXN_DROME
Sequence: MPHTGQAGVNQLGGVFVNGRPLPDCVRRRIVDLALCGVRPCDISRQLLVSHGCVSKILTRFYETGSIRPGSIGGSKTKQVATPTVVKKIIRLKEENSGMFAWEIREQLQQQRVCDPSSVPSISSINRILRNSGLWTDEMTSSQQNAAAAAAAAAAAAHQAGSGPSNGYGGQAPPPPVTVAPPTPAATPSIARYAKPPALMMNSAGEMPIKPAPKMPPSMGHGHSHGLNPNVSGLDLSYSALHKHWLWNPSLLYYTQAHIQAQAAASGGQFLPYAGGYLPHAMAAAAASSTSALGGFTKSESSIDLSTPGAAGDALSDCDSGKSSPAALSLTASGGGNGAGSAPEASPGSTLSHSRKRNPYSIEELLKKPEKRLRLDSNRLECLESSSCESSQDSPVAPPLETPEDEDPAEAEEEQEEEDSVEVVN
What is the function of this protein?
Transcriptional regulator that specifies poly-innervated organs (chemosensory bristle).  Also controls the number of neurons.
What are the official names of this protein?
Paired box pox-neuro protein, Paired box neuronal protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: KLF13_MOUSE
Sequence: MAAAAYVDHFAAECLVSMSSRAVVHEPREGPEPRPEGAAAAAPTLPRVDERRDGKDSASLFVVARILADLNQQAPAPAPAERREGAAARKARTPCRLPPAPPAPPPGPEPASPGQAGAPAAPPSPAWSEPEAALEQEPGPAGSGEPGLRQRGRRGRSRADLESPQRKHKCHYAGCEKVYGKSSHLKAHLRTHTGERPFACSWQECNKKFARSDELARHYRTHTGEKKFSCPICEKRFMRSDHLTKHARRHANFHPGMLQRRGGGSRTGSLSDYSRSDASSPTISPASSP
What is the function of this protein?
Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage.
What are the official names of this protein?
Krueppel-like factor 13, Basic transcription element-binding protein 3, BTE-binding protein 3, Erythroid transcription factor FKLF-2, RANTES factor of late activated T-lymphocytes 1, RFLAT-1, Transcription factor BTEB3.
What is the protein family that this protein belongs to?
Belongs to the Sp1 C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYH_DESPS
Sequence: MLIGYILGDGTLKIKVLKGFKDILPGEVELWQQVEKITRDIFTRHNFSEIRMPILEQTDLFARSIGEATDIVEKEMYTFVDKKVTMRPEATASLIRAYIENGLYVAKPVQRLFTIGPMFRHERPQKGRLRQFHQMDIEVLGSVNPLVDAELMAMGSMVFRTLGINVRLEMNSLGCPECRPVYRQALVEFIEDRFEHLCDDCKRRSKTNPLRVLDCKNAGCRAQVEEAPSILDYLCGDCADHFDTVCTTLESLEIPYSLNKFMVRGLDYYCRTTFEFITDDLGAQSAVGAGGRYDGLVEKLGGPVGMPGIGFAIGMERLILLLQQKETEFVAEKLDLFVIGLGDAATKLACILSQDLRGLGVGVAVDYEGRSLKAQMKLANKAGVAATLILGENEIETGKAVLKNMDSQEQCEVALVAGDIFAALAMSAQ
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGALB_TALMQ
Sequence: MAQLFTKIIVYFLLFASPLLANQWPLHNNSLNDVVQWDHYSFEINGQRLFVFAGEWHYWRIPVPELWIDILEKIKAAGFTAFGIYVNWAYHAPNNYTVDFATGAHDITPILKMAKDVGLYVLLRPGPYINAEVNAGGFPLWVTTGEYGSLRNDDSRYTAAWEPYFTKISEIASEYQITKGGNVVTYQIENEFGDQWTGSPSRRVQYEPAAKYMELLEANARRNGIDIPLVANEPNMRAISWGKDWSNSSANVDVVGLDSYPSCWTCDLSVCTGTTGEYIAYQVIDYYGYFQETQPTMPSFFAEFQGGSYNPWGGPVGGCPEDIGPDFANLFYRWNIGQRVTAINLYMLYGGTNWGAIAAPVVASSYDYSSPISENRTIGAKYYETKLLTMFTRAARDLIVTDLIGNGTQYSTNPAIQTHVIRNPITNGTFYVTLHTISSSSTDETFQLHVNTSAGAFSIPRYGNSIRLNGHQSKIIVTDFQFGTHKLLYSTAEVLTYTVLDGIPTLALWVPTGESGEFSVLGGKWASVLRCEWCSDIQFHPEQDQTSNPTVSRLTVSFTQGQGMSVIKLDTGLRVVLLDRESAYYFWAPALNSDPSVPEDQSVLVQGPHLVRSAKIVGSTIRLTGDSAQTSPIEVFAPKQVRIIFWNDKELKTSKTSYDSLQASLPQPAYVKLPLLGPWKYNGSLPEKAQDYKDTSAAWISADHMKTSNPSPPATFPVLYADEYGFHNSIRIWRGYFTGNATGVVLKVQGGYAFGFSGWLNGKLLGSYLGNASVEHSHLTLPFNVSHVSTSSDNVLVIVHDDTGHDETTGALNPRGILEATLLSDNSSSKFSHWRVAGTAGGETNIDPMRGPYNEGGLYAERMGWHLPGFNDNAWSDAGSKLNFTGADIKFYRTTVPLNIPKGVDVSISFELSACGTTNAFRSQLFVNGYQMGRFNPWVGNQIEFPVPPGILDYTGDNTIGLSLWAQTEDGACAIVDWKINYVLGSSLDVTFNGEYLRPGWTSERLQYS
What is the function of this protein?
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
What are the official names of this protein?
Probable beta-galactosidase B, Lactase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PHO_DROME
Sequence: MAYERFGIILQSEQYDEDIGNTKVNQKMNEGNHYDLHRKNAFDRIIHSESKKGDNVINYNIHENDKIKAADNIFSSKLKMNPNMSYEMNINCFKNIGYGENQETSKVLTNSLSNNDINTEESGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIKTMEGEFSVTMWASGISDDEYSGSDQIVGASDLLKGKEEFGIDGFTSQQNKEYQKMESKFTNAQTLEMPHPISSVQIMDHLIKERGNLSQENNISERILSKTTLSFEEPILLPDSSSIELVNETAAMTINNHRTLSNHTGNTGDLHALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRNTSISGKSGCSNAESNSQSEDTSANYVKVELQDSVTENHVPFVVYAD
What is the function of this protein?
Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
What are the official names of this protein?
Polycomb protein PHO, Protein pleiohomeotic, Transcription factor YY1 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVA_MYCBP
Sequence: MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLYGFPDGETRDLFLTLLSVSGVGPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGAERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGFAAKQAEEATDTVLAANHDATTSSALRSALSLLGKAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PUR7_XANOM
Sequence: MPVSTTLLQSDLPGLPLRHRGKVRDVFDIPRDRLPADAPPGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFHKTEHLMPNHLVDIRVEQVLPEGVDPALYAKRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKISGIELPDGLRQAEKLPEPIFTPSTKAAVGDHDENIDFDAMVKTVGAELAERVRDATLRIYRFAADFAAECGILLADTKFEFGTDADGRLYVMDEMLTPDSSRYWPADQYELGTSPPSYDKQFVRDYLETLDWGKTAPGPSLPADVIDRTRAKYAEALQRLAGISVD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: MYH3_HUMAN
Sequence: MSSDTEMEVFGIAAPFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKPEDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE
What is the function of this protein?
Muscle contraction.
What are the official names of this protein?
Myosin-3, Muscle embryonic myosin heavy chain, Myosin heavy chain 3, Myosin heavy chain, fast skeletal muscle, embryonic, SMHCE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Protein: PANB_PARPJ
Sequence: MTYLQEASRNAITVPKLQAMRDAGEKIAMLTCYDASFAALLDRAGVDVLLIGDSLGNVLQGQTTTLPVSLADIAYHTASVARARPAALIVADLPFGTYGTPEDAFRSSVELMRAGAQMVKLEGGEWLADTVRFLVERSIPVCAHVGLTPQSVHAFGGFKVQGKTEAGATQLMRDSLAVQQAGAQLIVMEAIPTLLASDVTKQLRIPTIGIGAGLDCSGQVLVLHDMLGIFPGKRPRFVKDFMHGQPSILAAVEAYVAAVKDGSFPGPEHTF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAG2_CHICK
Sequence: MSLQMVSAVSNSSLLQPGSSLLNFDGHVFFFGQKGWPKRSCPTGVFFLDIKQNELKMKPAAFSRDSCYLPPLRYPAICTLRGNGESDKHQYIIHGGKTPNNDLSDKIYIMSMVNKTTKKTTFQCIEKDLGGDVPEARYGHTINVVHSRGKSMIVIFGGRSYIPLAQRTTEKWNSVVDCLPSVFLVDFEFGCCTSYILPELQDGLSFHVSVARDDTIYILGGHSLQNNTRPPSLYKLKVDLPLGSPCVTCSILPGGISVSSGIVTQTGDTEFVLVGGYQSDNQKRMICNTIVLEDNKIEIVERVSPDWTPDIKHCRMWFGCDMGKGSVLLGIPGANKQLISDANYFYILRCNKAEEDEEEELTAQTCSQASTEDQGDSTPFEDSEEFSFSAEASSFDVDDIDTYNEDDEEDESETGYWIICCASCNIDINTWVPFYSTELNKPAMILCSSGSGHWVHAQCMDLSESMLLQLSEANVKYFCNEHVHLNKGLQTPKKAVHLKKQPMKRLHKKKTMKLTTPVKKSFLRRLFE
What is the function of this protein?
Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination.  V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments.  DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.  In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1.  It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity).
What are the official names of this protein?
V(D)J recombination-activating protein 2, RAG-2.
What is the protein family that this protein belongs to?
Belongs to the RAG2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDH_ECO5E
Sequence: MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVARKPGMDRSDLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGEEFVNK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: ENGB_MYCPU
Sequence: MLHFIKSASNSQSWYNHDKVEICFIGRSNVGKSSLINSLSNSAVSKVSNTPGRTQLINFFEDDQKNVYVDLPGYGFAQMPKDKLEKMHQMIDEYLQNRKNLKTIVLLFDSRRGILDQDLDFINWAQQAKKNIILLATKIDKLNQAQKHKLLVSLKELNLEKSVLLVSSLKRTNIDNLKKLLASEFK
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: LOLB_PSEU2
Sequence: MFLRHVIVFSLIALLTGCAGLTSREAVQGKGDPAQWREHKQQLSSLDGWQINGKVGIRAPKDSGSGTLFWLQRQDYYDIRLSGPLGRGAARLTGRPGAVVLEVANQGRYEATSPESLLQDQLGWKLPVSHLVWWVRGLPAPDSKSNVTLDGDSRLASLEQDGWQVEYLSYVEQNGYWLPERVKLHGQDLDVTLVIKDWQPRKLGQ
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: LTV1_BOVIN
Sequence: MPHRKKKPFIEKKKAVSFHLVHRSQRDPLAADETAPQRVLLPTQKIKDEERRAEQRKYGVFFDDDYDYLQHLKEPSGPSELIPTSPFGAPYRGDGREEPLATSTSGIKLPSSVFASEFEEDVGLLNKAAPVSGPRLDFDPDIVAALDDDFDFDNPDNLLEDDFILQANKPTEEEEGMEIQKSEAEDDSEWEDVDDEKEGGSDDDRYDRAGSSDEDMSAPGKPLGAIENHFFWEEETKSRFTEYSLTSSVMRRNEQLTLHDERFEKFYEQYDDDEIGALDNAELEGSIQVDSNRLEEVLNDYYKEKAENCVKLNTLEPFEDQDLPVNELDGSEEEETVTVVLEEAKEKWDCESICSTYSNVYNHPQLIKYQPKPKQIRLSSKTGIPLNVLPKKGLTAKQVERMQMINNSDLPKTSTQPRLKRESKEDKRARKRAIKEERKERRVEKKANKLAFKLEKRRQEKELLNLKKNVEGLKL
What are the official names of this protein?
Protein LTV1 homolog.
What is the protein family that this protein belongs to?
Belongs to the LTV1 family.
Protein: BSDC1_DANRE
Sequence: MADGEGGWWGGWLTQSFQSVKDKSAEAYEFIKRDLTEFSSVVQHDTACSVVATANAIKSKLAVEGSSETTEKVKKGITNILGVITDTLAPPPDKTIDCDVITLVATPTGTTEVYDSGKARLYSLQADPATYCNEPDGPPQQFDSWLSTFSLEERKAEISELLVSSPAIRALYTKMVPAAVAHAEFWQRYFYKVFQLEQEEARRVALKQRAEQTDHSESLGWEEEDEEGEFLGATSLSRLDFTPPVEESRVPAVTVADTPESSSPPQAVASLSNVASDVTPSVSSDSVSFPTQIENQAESVTIRVTQPSPAADELSQKLSDTGLQETFPEERPAPREETAREDMAQDLRVFELNSDSGKSTPSNNGKKGSSTDVSEDWEKDFDLDMTEEEVQMALSKVDATEELEDEDWENWE
What are the official names of this protein?
BSD domain-containing protein 1.
Protein: PANB_CUPPJ
Sequence: MSYLLDPSRKTVTITRLQAMRDAGEKIAMLTAYDSSFAALLDYCGVEVILVGDSLGNVMQGQQTTLPVTLEHMAYHTECVARANQTALLVTDLPFGTYGTPEMAFASAVTLMRAGAHMVKLEGGDWLAPTVKFLVERSIPVCAHIGLTPQSVHAFGGFKVQGKTDEGAAQLRRDAQAMEAAGAQIVLMEAVPATLAGEITQMLKVPTIGIGAGADCSGQVLVLQDMINVYPGRKAKFVRNFMDGQTTIEGAIRAYVAAVKDGSFPAAEHTFSA
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CX7A2_SHEEP
Sequence: FENKVPEKQKLFQEDNGIPVHLKG
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 7A2, mitochondrial, Cytochrome c oxidase subunit VIIa-liver/heart, Cytochrome c oxidase subunit VIIa-L.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIa family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: YM42_CAEEL
Sequence: MELSPNLKSNLNSEMNDLVQQAEEWAQSQHRSASPGALKDPKLCAIYKMILQNSALLLIEKSGVKTVEEFQKVFGPIIEEQKNKEDEIIEFEEFEEIEKARAELASPTSFTKYSMMLDEPLSASPFNRRRTSLFSDLHVLSPIASASSESFEKPKRFASSTQHAKKSFVTVESTRTPWRRSNSMYLEDVLNRTINTPLKSHSASRLNHLTPSPRPGETPLENRASRLRRMKIEEKMNENF
What are the official names of this protein?
Uncharacterized protein K11H3.2.
Protein: BPT_METC4
Sequence: MTSHPRDTPQFYLTAPSPCPYLPGQEERKVFTHLVGRRARDLNEILTQGGFRRSQTIAYRPACETCRACVSVRVVVEDFAITGSQRRILQRNAELIGTPEPNRPASEQYALFRRYLDARHGDGGMVDMTVLDYAMMIEDSHVDTHLVVYRERGPDSAIHGRGVGAPVAVCLTDVLADGLSMVYSFYDPDEASRSLGTYMILDHIRRARALGLPYLYLGYWVDGSRKMDYKAKFKPQERLMPQGWVRVE
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y907_STAAN
Sequence: MSRKTYEKIANINGMFNMLEQQIIHSQDMAHFRSEFFYVNHEHRENYEALLIYYKNSIDNPIVDGACYILALPEIFNSVDVFESELPFSWVYDENGITETMKSLSIPLQYLVAAALEVTDVNIFKPSGFTMGMNNWNIAQMRIFWQYTAIIRKEAL
What are the official names of this protein?
Uncharacterized protein SA0907.
Protein: RL35_HALH5
Sequence: MPKMKTHKGAAKRFKKTGSGKLKRSHAFTSHLFANKSQKQKRKLRKSAIVHSGDFKRIREMLTYKK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RL17_NITEU
Sequence: MRHRNGLRKLNRTSSHRLAMFRNLTNSLLEHEIIKTTLPKAKELRRVVEPVITLGKNPSLAGKRLAFDRLRNRDNVIKIFSELGPRYQNRNGGYIRILKCGFRRGDNAPMAIVELLDRPEAGIISNDSAD
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.