PharMolix/UniProtQA huggingface dataset:
Protein: UBP44_HUMAN
Sequence: MLAMDTCKHVGQLQLAQDHSSLNPQKWHCVDCNTTESIWACLSCSHVACGRYIEEHALKHFQESSHPVALEVNEMYVFCYLCDDYVLNDNTTGDLKLLRRTLSAIKSQNYHCTTRSGRFLRSMGTGDDSYFLHDGAQSLLQSEDQLYTALWHRRRILMGKIFRTWFEQSPIGRKKQEEPFQEKIVVKREVKKRRQELEYQVKAELESMPPRKSLRLQGLAQSTIIEIVSVQVPAQTPASPAKDKVLSTSENEISQKVSDSSVKRRPIVTPGVTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDTVVYQMNECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQRELETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKDIASQPCLVTEMLAKFTETEALEGKIYVCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIGVHVGFEEILNMEPYCCRETLKSLRPECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGFWVHCNDSKLSMCTMDEVCKAQAYILFYTQRVTENGHSKLLPPELLLGSQHPNEDADTSSNEILS
What is the function of this protein?
Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset.  Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (PubMed:17443180).  Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C (PubMed:17443180).  Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint (PubMed:17443180).  Promotes also the deubiquitination of histone H2A and H2B (PubMed:23615962, PubMed:27880911).  Recruited to RNF8/RNF168-ubiquitinated chromatin surrounding double stranded breaks (DSBs), promotes hydrolysis of such ubiquitin conjugates, thus negatively regulating protein recruitment to damaged chromatin (PubMed:23615962).  Participates in nucleotide excision repair (NER) pathway by deubiquitinating DDB2 to prevent its premature degradation so it can remain on damaged chromatin (By similarity).  Promotes FOXP3 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability and increased regulatory T-cell lineage stability (PubMed:32644293).  Plays also a positive role in innate immune response to DNA viruses by deubiquitinating STING1, selectively removing its 'Lys-48'-linked polyubiquitin chains and stabilizing it (PubMed:31968013).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 44, Deubiquitinating enzyme 44, Ubiquitin thioesterase 44, Ubiquitin-specific-processing protease 44.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP44 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Peaks in interphase, with relatively low levels maintained throughout mitosis.
Protein: SPB10_RHIFE
Sequence: MDSLTKSINQFALEFSKKLAESAEGKNIFFSPWGISTSLAMVYLGTRGTTAAQIAQVLQFNRDQDSKFFPESEKKRKMDFNSRKVEEIRSDFQTLISEINNPSNAYVLKTANGIYGEKTYPFHNKYLEDMKTYFGVEPQSVNFLEAPDQTRNEINSWVESQTQGKILNLLPDDAVDSATRMVLVNAIYFKGIWEHQFSARDTREKPFRINKNTSKPVQMMSMKKKLQVFHIENPQAIGLQLYYESRDLSLFLLLPEDVSGLDQLEKAVTYEKLSEWTSADMMELYDVQLHLPKFKLEESYDLKSALSSMGMSDAFNQSKADFSGMSVEGNLFLSNVFHKSFVEINEQGTEASAGTGSEVSLRIRLPSIEFNADHPFLFFIRHNKTNSILFYGRFCSP
What is the function of this protein?
Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF.  May regulate protease activities in the cytoplasm and in the nucleus (By similarity).
What are the official names of this protein?
Serpin B10, Proteinase inhibitor 10.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Ov-serpin subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CDH_ECOBW
Sequence: MKKAGLLFLVMIVIAVVAAGIGYWKLTGEESDTLRKIVLEECLPNQQQNQNPSPCAEVKPNAGYVVLKDLNGPLQYLLMPTYRINGTESPLLTDPSTPNFFWLAWQARDFMSKKYGQPVPDRAVSLAINSRTGRTQNHFHIHISCIRPDVRKQLDNNLANISSRWLPLPGGLRGHEYLARRVTESELVQRSPFMMLAEEVPEAREHMGRYGLAMVRQSDNSFVLLATQRNLLTLNRASAEEIQDHQCEILR
What are the official names of this protein?
CDP-diacylglycerol pyrophosphatase, CDP-diacylglycerol phosphatidylhydrolase, CDP-diglyceride hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Cdh family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CRTY_PANAN
Sequence: MQPHYDLILVGAGLANGLIALRLQQQQPDMRILLIDAAPQAGGNHTWSFHHDDLTESQHRWIAPLVVHHWPDYQVRFPTRRRKLNSGYFCITSQRFAEVLQRQFGPHLWMDTAVAEVNAESVRLKKGQVIGARAVIDGRGYAANSALSVGFQAFIGQEWRLSHPHGLSSPIIMDATVDQQNGYRFVYSLPLSPTRLLIEDTHYIDNATLDPECARQNICDYAAQQGWQLQTLLREEQGALPITLSGNADAFWQQRPLACSGLRAGLFHPTTGYSLPLAVAVADRLSALDVFTSASIHHAITHFARERWQQQGFFRMLNRMLFLAGPADSRWRVMQRFYGLPEDLIARFYAGKLTLTDRLRILSGKPPVPVLAALQAIMTTHR
What is the function of this protein?
Catalyzes the double cyclization reaction which converts lycopene to beta-carotene (PubMed:2254247, PubMed:11943208, PubMed:20178989).  Also catalyzes the double cyclization reaction which converts neurosporene to 7,8-dihydro-beta-carotene via monocyclic beta-zeacarotene (PubMed:8898919).  May also convert zeta-carotene to bicyclic 7,8,7',8'-tetrahydro-beta-carotene (PubMed:8898919).
What are the official names of this protein?
Lycopene beta-cyclase, Lycopene cyclase.
What is the protein family that this protein belongs to?
Belongs to the lycopene cyclase family.
What are the subcellular locations of this protein?
Cell inner membrane. Note=Membrane-bound.
Protein: NUOD_BARHE
Sequence: MAEVNVRNFNINFGPQHPAAHGVLRMVLELDGEVVERVDPHIGLLHRGTEKLMETKTYLQAGPYLDRLDYVAPMNQEHAFVLAIEKLLGVEVPKRGQLIRVLFSEIGRILNHLLNVTTQAMDVGALTPPLWGFEQRERLMIFYERACGARLHANYFRPGGVHQDLPESLVEDIGNFIDPFLIALGKLDALITPNRIFKQRNVDIGVVSIDEAWARGFSGVMIRGAGVPWDLRKSQPYECYDEMEFDIPVGKNSDCYDRYLIRMEEMRQSAKIMRQCVDRLLSTEKNEPVSSLDRKIVPPKRCEMKSSMEALIHHFKLYTEGFRTPPGEVYVAVEAPKGEFGVYLVSDGTNKPYRVKLRAPGFAHLQAMDFLTRGHMLADATAILGSIDIVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACHA9_CHICK
Sequence: MKRNNLSSFYVSLWLLFTATMLQAVESAKGKYAQMLFNELFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQSWYDAYLKWDKDKYDGLDSIRIPSNLVWRPDIVLYNKADDDFSEPVNTNVVLRYDGKITWDAPAITKSSCVVDVSYFPFDSQQCNLTFGSWTYNGNQVDIINSLDSGDLSDFVEDVEWEIHGMPAVKNVITYGCCSEPYPDVTFTLILKRKSSFYIFNLLLPCILISFLAPLGFYLPADSGEKVSLGVTVLLALTVFQLMVAEIMPPSENVPLIGKYYIATMTMITASTALTIIIMNVHHCGSEAKPVPQWARVVILDYMSKIFFVYDVGENCTSPRREKEQEHRLEGGDMCRGGDGKSHLSSRNDDSDLKENLNGNWNKSFGVHGENVRENVNCCSCYKMLIKNIEYIANCVRDHKANRAKGIEWKKVAKVMDRFFMWIFFIMVFFMSVLIIGKAA
What is the function of this protein?
Ionotropic receptor that may play a role in the modulation of auditory stimuli.  Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane.  The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-9, Nicotinic acetylcholine receptor subunit alpha-9, NACHR alpha-9.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: KATG_PELPB
Sequence: MSEQGKCPVTGRTAVNPVTTGGMSNRDWWPNQLHLDMLHQHSSLTNPMGEEFRYKEEFKKLDLKSVKKDLYALMTDSQEWWPADYGHYGGLFIRMAWHSAGTYRTSDGRGGGGTGNQRFAPLNSWPDNANLDKARRLLWPIKQKYGRKLSWADLMILAGNCALESMGFKTFGFGGGRVDIWEPEEDIYWGKEVEWLGSNRYSGERDLENPLAAVQMGLIYVNPEGPDGNPDPVAAGRDIRETFARMAMNDEETVALVAGGHTFGKCHGVGDPKLIGPEPEAAEIEEQGLGWKSGYGSGKGDETMTSGLEGAWTPDPIHWDMGYLGMLFKYEWELTKSPAGAWQWKPKDVAEEDLAPAAHDPSKRVPTMMTTADLAMRMDPLYGPIARRYYEHPEQFADAFARAWFKLTHRDMGPRSRYLGAEVPAEELIWQDPVPAVDHELIGEGKIKELKKRILASGLSIPELLSTAWASASTFRSSDKRGGANGSRIRLSPQKEWEVNQPEQLQRVLGKLEEIRNAFNGEQSGGKQVSLADLIVLGGCAAVEEAARRAGNDVTVPFIPGRTDASQEQTDVESFAVLEPLADGFRNYTKRKYSVTPEEMLIDRSQLLTLTATEMTVLLGGLRVLGVNFRQSPHGLFTNRPETLTNDFFVNLLDMGTEWKPLSKEHETFEGRDRKTGEVRWSATRVDLIFGSNARLRAIAEVYGSDDAQGKFVQDFVAAWNKVMNLDRFDLS
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: AROE_ECOLC
Sequence: METYAVFGNPIAHSKSPFIHQQFAQQLNIEHPYGRVLAPINDFINTLNAFFSAGGKGANVTVPFKEEAFARADELTERAALAGAVNTLMRLEDGRLLGDNTDGVGLLSDLERLSFIRPGLRILLIGAGGASRGVLLPLLSLDCAVTITNRTVSRAEELAKLFAHTGSIQALSMDELEGHEFDLIINATSSGISGDIPAIPSSLIHPGIYCYDMFYQKGKTPFLAWCEQRGSKRNADGLGMLVAQAAHAFLLWHGVLPDVEPVIKQLQEELSA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: RBSD_THENN
Sequence: MKKVGILNSEISKIVADMGHMDTLAVVDLGFPIPQGVKKVDLVVDRGKPGLMEVIEILLRELKVERIILAKEMDEKSIQTKQELLKLIEKMNGPVEVVTVPHKEFKEMSKNVKGIIRTGADIPYSNVILVGGVIF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O10K1_HUMAN
Sequence: MEQVNKTVVREFVVLGFSSLARLQQLLFVIFLLLYLFTLGTNAIIISTIVLDRALHTPMYFFLAILSCSEICYTFVIVPKMLVDLLSQKKTISFLGCAIQMFSFLFFGSSHSFLLAAMGYDRYMAICNPLRYSVLMGHGVCMGLMAAACACGFTVSLVTTSLVFHLPFHSSNQLHHFFCDISPVLKLASQHSGFSQLVIFMLGVFALVIPLLLILVSYIRIISAILKIPSSVGRYKTFSTCASHLIVVTVHYSCASFIYLRPKTNYTSSQDTLISVSYTILTPLFNPMIYSLRNKEFKSALRRTIGQTFYPLS
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 10K1, Olfactory receptor OR1-6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SUBT_BACSA
Sequence: MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFKQTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHIAHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSETNPYQDGSSHGTHVAGTIAALNNSIGVLGVSPSASLYAVKVLDSTGSGQYSWIINGIEWAISNNMDVINMSLGGPSGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSSSTVGYPAKYPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVAGAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ
What is the function of this protein?
Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides.
What are the official names of this protein?
Subtilisin amylosacchariticus.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRUB_STAAM
Sequence: MYNGILPVYKERGLTSHDVVFKLRKILKTKKIGHTGTLDPEVAGVLPVCIGNATRVSDYVMDMGKAYEATVSIGRSTTTEDQTGDTLETKGVHSADFNKDDIDRLLENFKGVIEQIPPMYSSVKVNGKKLYEYARNNETVERPKRKVNIKDIGRISELDFKENECHFKIRVICGKGTYIRTLATDIGVKLGFPAHMSKLTRIESGGFVLKDSLTLEQIKELHEQDSLQNKLFPLEYGLKGLPSIKIKDSHIKKRILNGQKFNKNEFDNKIKDQIVFIDDDSEKVLAIYMVHPTKESEIKPKKVFN
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: 50511_ASFWA
Sequence: MFSLQKKALQHIYMTPENASQLTKDLLQHLGLYWNGPIIKMDTVVHLHNKIFSNRSVLKYALAKQANITIIKTLVLWVEPEYALAQALKHNRKDVLECIFSYHLTTPKYHHIMHLTSSQELFEFFHLFICKSKNYNARMECLLYAATLYNFPNILEKNREYIIRYSIGNSLFAIACKERHIHLIAWFVTAGVLDTYDDSMLFNTAFKLGDYSLLEVACDLPIIYPDYLIISMMQTAIQKNYFRFFKKLLTHFNIYRQIIITDAAYYNRRKILLLLLKQNIFNNFAILCALSAAIKGHASKKTLNLLISQLDSQMTVVDSVYYSIIKYNNIDCIPLLMQIKTFRMETLVSIAVHGNNINIIAACKAFLPKDTLYHLVLKMAIVSRNYKLFKLYTEKENPMYIFTTIKAIISNLVNYTVVQAVAIEYLRKFHQERQLPIVPLLMVLAEHNYITKFKKTCYAANMSDQKVKRALIKCLFIASQKNYCQIFKYCFGSLLKVLSKHERVKFFNSVVFAKKLASYYDHQNMIHLIDSLIERFRYLIKD
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 505-11L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 505 family.
Protein: PSB1_RAT
Sequence: MLSTAAYRDPDRELVMGPQGSAGPVQMRFSPYAFNGGTVLAIAGEDFSIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIEGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLTLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVPLRKD
What is the function of this protein?
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit beta type-1, Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome component C5, Proteasome gamma chain.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
Protein: DAPB_RICB8
Sequence: MIINIGLSGATGKMGRTILERIDNFKNCKISAKFNSTRDLHELNDLCKNSDVVIDFSTPEILEKLVDSALKYDTKLVIGTTGFTSSQFKLLEKAAKTLPILYSANMSIGANLLGYLAKEATKILDDYDIEILEAHHRAKKDAPSGTAIMLAEMVTAEKELDITFNRGNKTRRTNEIGISSLRGGNVHGTHEIFFLGDDETITLKHEALNKNSFADGAIRAAIWLQDKQTGLYSMLDFYKNLINYHLKKPI
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARL1_DROME
Sequence: MGGVLSYFRGLLGSREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSADRDRIGISKDELLYMLREEELAGAILVVLANKQDMDGCMTVAEVHHALGLENLKNRTFQIFKTSATKGEGLDQAMDWLSNTLQSRK
What is the function of this protein?
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
Protein: RS14Z_STRPC
Sequence: MAKKSMIAKNKRPAKHSTQAYTRCEKCGRPHSVYRKFKLCRVCFRELAYKGQIPGVVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: VIAA_PROMH
Sequence: MLTLSTIDMLLAINEGQLIEEVIITLLASPQLAVFFEKHPRLKKALLKDIYQWKKSLQEKVKETLVPTIIADEFALYQQTQSLCNAVFNQQVDNILTELNQLDSSFVIEATQLIKTNKPFSPAQQALFIQRWRISLIFQVTTLHKALFEQEQEQLLAELQERLALSGSLSNTFSENERAAGRLWDMSKGVITKTPYDEKIIQRYSDFLNQQPELHKLASLLGRSKTAKSLPEESVIFESITIVEKAPDTTPEQVNGIGLSDDILRLLPAELALLGINEVEYEFYRKLIEKQLNTYRLQGDSWQERTVLRPVTHHLDEERPRGPFIICIDTSGSMGGFNEQCAKAFGLALMKIALADNRACHVMLFSTEMIHYQLSSSDGLQELVKFLNQTFRGGTDLASCLNEVADKLNTPTWKDADAVVISDFVAQRLPENLINKIKKVQQQQHNRFHAVTLSNYGKPSIMKIFDHIWRFDTGLKSRLLRRWRQ
What are the official names of this protein?
Protein ViaA, VWA domain protein interacting with AAA ATPase.
What is the protein family that this protein belongs to?
Belongs to the ViaA family.
Protein: HESXB_XENLA
Sequence: MSPALQKGSSLMENRSPPSSFSIEHILGLDKKTDVASSPIIKHHRPWIECSSKGVVNGTCWQIPVIACDLPIQVHAVHRSEEEETKIRLEKCFGDEDRLTYKRELSWYRGRRPRTAFTRSQIEILENVFRVNSYPGIDVREELASKLALDEDRIQIWFQNRRAKLKRSHRESQFLIVKDSLSSKIQE
What is the function of this protein?
Regulates the earliest stages of development of the anterior neural plate.  Plays a role in forebrain development by inhibiting the expression of otx2 and pax6 in the rostral region of the anterior neural plate.  Necessary for both neural differentiation and neural patterning.  Controls Spemann organizer development.  May act as a transcriptional repressor.
What are the official names of this protein?
Homeobox expressed in ES cells 1-B, Homeobox protein ANF-1, XANF-1, Xanf1.
What is the protein family that this protein belongs to?
Belongs to the ANF homeobox family.
What are the subcellular locations of this protein?
Nucleus. Note=Enters the cytoplasm in the presence of zyx.
Protein: KUP_STRPD
Sequence: MSDSHLTAFDKASKAGFIIALGIVYGDIGTSPLYTMQSLVENQGGVNQVSESFILGSISLIIWTLTLITTIKYVLIALKADNHHEGGIFSLFTLVRKMSPWLIIPAMIGGATLLSDGALTPAVTVTSAIEGLKAVPGLSHIYQNQTNVIITTLVILIVLFGIQRFGTGFIGKIFGPVMFIWFSFLGVSGFFNTLGHLEIFKAINPYYALHLLFSPENHRGIFILGSIFLATTGAEALYSDLGHVGRGNIYVSWPFVKMCIVLSYCGQAAWILANKHSGIELNPFFASVPSQLRGYLVSLATLAAIIASQALISGSFTLVSEAMRLKIFPLFRVTYPGANLGQLYIPVINWILFAVTSCTVLAFRTSAHMEAAYGLAITITMLMTTILLKYYLIKKGTRPILAHLAMAFFALVEFIFFLASAIKFMHGGYAVVILALAIVFVMFIWHAGTRIVFKYVKSLNLNDYKEQIKQLRDDVCFNLYQTNVVYLSNRMQDYMIDRSILYSILDKRPKRARVYWFVNVQVTDEPYTAKYKVDMMGTDYMVRVNLYLGFRMPQTVPRYLRTIVQDLMESGRLPKQEQEYTITPGRDVGDFRFVLIEERVSNARQLSNFERFIMQTKASIKHVTASPMRWFGLQYSEVTLEVVPLILSDVLKLPIKELVPVEDSEA
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL9_YERPN
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNVEFFEARRAELEAKLADVLAAAEARATKINELVSVTISSKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTAGEHEVHFQVHSDVFAKLNVVVVPEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: NU2M_ANACA
Sequence: MNPRATPVLVLSLALGTTITISSNHWVLAWTGLEINTLAIIPLISKSHHPRAVEAATKYFLTQAAASALVLFSSMTNAWATGQWDITQLNHPTSCLLLTAAIAIKLGLVPFHFWFPEVLQGSPLMTALLLSTLMKFPPLTLLLMTSKSLNPALLTAMALASTALGGWMGLNQTQTRKILAFSSISHLGWIAIILVYSPKLALLTFYLYTIMTSAVFMALNKIKALNLSMILISWTKTPVLNTTLMLVLLSLAGLPPLTGFMPKWLIIQELTKQEMTPAAMAIAMLSLLSLFFYLRLAYHSTITLPPNSSNHMKQWYTSKPPSTPTAILASLSILLLPLSPMVHAIV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SXL_DROSU
Sequence: MYGNNNPGSNNNNGGYPPYGYNKSSGGRGFGMSHSLPSGMSRYAFSPQDTEFSFPSSSSRRGYNEFPGGGGIGIGANGGSANNLGGNMCNLLPMTSNNSLSNLCGLSLGSGGSDDHMMMHDQRSSNTNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVLNGITVRNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRLAQEHGKAKAAHFMSQIGVPSANAPPPPPPPPHMAFNNMVHRGRSIKSQQRFQKTHPYFDAQKFI
What is the function of this protein?
Sex determination switch protein which controls sexual development by sex-specific splicing.  Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes.  Expression of the embryo-specific isoform is under the control of primary sex-determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio).  Expression occurs in 2X:2A cells, but not in X:2A cells.  The X:A ratio seems to be signaled by the relative concentration of the X-linked transcription factors SIS-A and SIS-B.  As a result, the embryo-specific product is expressed early only in female embryos and specifies female-adult specific splicing; in the male where it is not expressed, the default splicing gives rise to a truncated nonfunctional protein.  The female-specific isoform specifies the splicing of its own transcript, thereby initiating a positive autoregulatory feedback loop leading to female development pathway.  The female-specific isoform controls the sex-specific splicing of transformer (TRA); acts as a translational repressor for male-specific lethal-2 (MSL-2) and prevents male-less (MLE), MSL-1 and MSL-3 proteins from associating with the female X chromosome (By similarity).
What are the official names of this protein?
Protein sex-lethal.