PharMolix/UniProtQA huggingface dataset:
Protein: BETA_ECO8A
Sequence: MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEGDSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGTECQTDEQLDEFVRNHAETAFHPCGTCKMGYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALPRSTAGYFVANGMPVRAKK
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: TDH_SALHS
Sequence: MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDDWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGVMAAAVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMSGAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDDFQKGFDAMRSGQSGKVILSWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASR_YERPG
Sequence: MKKVLALMVAATLGLSSVAFAADTTATATPAATSTTATVAAQTKATQHQKHKVTKKTTEQKAQAAKKHEKKASVQKTPVQKAQAAKKHVKKASVQKAPVQKAQAAKKHHKTAKKPVAAPAA
What is the function of this protein?
Required for growth and/or survival at acidic conditions.
What are the official names of this protein?
Acid shock protein.
What is the protein family that this protein belongs to?
Belongs to the Asr family.
What are the subcellular locations of this protein?
Periplasm.
Protein: NDC80_DANRE
Sequence: MSRRPSSRYSEMPMRVTDSRMSLINATPQNKDNAFGKLNIPKPQSTTSERRTSFFGKGIGAGGQRNSMFGSYGGSEKMKDPRALHDKAFVQQCIKQLYEFLVDRGFPGSITVKALQSPSTKEFLKIYEFIYNFLEPSFQMPTAKVEEEIPRMLKDLGYPFALSKSSMYSIGAPHTWPLALGALIWLMDAVKLFGGQREQDLLFSDFSDELCDLEDRTEYNKLIMEYCSDTYNKFMQGADTFDDEDDDFLYKLKKLYNVDEALLHSQQEKHSMLMEHVERLERESQTDRLVGKRTEKLRLQTDLQKLQNYRCTLEAHKTGLENKSAGLTEELEAVEMQLEGLKQERTRLQHILENQKFTPADIERINRERNELQQTIHGLSQSLEEGEQLVWNEEVNLSKTKEKAELKVAEYNKLGRKLKLIPLSAENACGHDFEIRADYSATTITQYKTQIQNPLKNMMVEVEEEFSRLSNVNLSLEETVEQVKSNIFDKENDIKQLKEQIRKVDQQLENAMQEMALEDDKWAAELDSAETHKKLFEKNVMQGIEEAEEEVKAAQQQYHVVVQETNEKNRMVVKNMTDLFSSTVNHLFAVEKHCDEQLKRFDKLKDIVREDEADINQLTDLVENFIKKANSL
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.  Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.  The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.  May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores to spindle microtubules.
What are the official names of this protein?
Kinetochore protein NDC80 homolog, Kinetochore protein Hec1, Kinetochore-associated protein 2-like.
What is the protein family that this protein belongs to?
Belongs to the NDC80/HEC1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
Protein: ANDA_EMEVA
Sequence: MTIESKNYPPIRRVNASQGSDAAYQILQEDGCVIVEQVICPNIIAKISDDVNRVMDKATIGAKKGEQTHIINMHNRTIHMGDLVLTSKTYRDELLNLPFAHEVLEKVFKKDSGDYWLNMGNILNMLPGAEAQRPHRDDYLYPVSQHMDPATSPDLMINITFPLNEFRHDNGGTLLLPKSHTGPNADFYANAEDLPAAEMQVGDALIFTGKCVHGGGANRSDKPRIGLALAAQPGYLTPRESNVNVPRDIVETMTPLAQRMIGWGTVRTKDTYGLNMLQDKDFHEALGLKSKTA
What is the function of this protein?
Dioxygenase; part of the gene cluster that mediates the biosynthesis of anditomin, a fungal meroterpenoid (PubMed:25216349).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase andM (PubMed:25216349).  DMOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHDMP) by the cytochrome P450 monooxygenase andK, which is further prenylated by the prenyltransferase andD to yield farnesyl-DHDMP (PubMed:25216349).  Further epoxidation by the FAD-dependent monooxygenase andE leads to epoxyfarnesyl-DHDMP (PubMed:25216349).  The next step involves the terpene cyclase andB that converts epoxyfarnesyl-DHDMP into preandiloid A through opening of the epoxide ring followed by the cyclization of the farnesyl moiety (PubMed:25216349).  Preandiloid A is in turn oxidized at the C-3 hydroxyl group to yield preandiloid B by the dehydrogenase andC (PubMed:25216349).  The dioxygenase andA is solely responsible for the dehydrogenation of preandiloid B leading to the enone preandiloid C, as well as for the intriguing structural rearrangement to generate the bicyclo[2. 2. 2]octane core, transforming preandiloid C into andiconin (PubMed:25216349).  FAD-binding monooxygenase andJ then produces andilesin D which is reduced by dehydrogenase andI to yield andilesin A (PubMed:25216349).  Action of acetyltransferase andG followed by a spontaneous acetate elimination leads then to andilesin B, which is in turn substrate of the short chain dehydrogenase andH to yield andilesin C (PubMed:25216349).  Finally, the dioxygenase andF catalyzes the transformation of andilesin C to anditomin (PubMed:25216349).
What are the official names of this protein?
Dioxygenase andA, Anditomin synthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: MTNC_XANC5
Sequence: MTRPQAILTDIEGTTSSISFVKDVLFPYARRAMPAYVREHGNHPQVRHWLNQVADEIGEDVPDEVLITTLQTWIDEDRKHTALKALQGLIWGDGYKTADFTAHIYADAAIQLKAWHAAGIPLYVYSSGSVPAQKLFFAHSDAGDLSGLITDWFDTEVGPKRESASYRRIAERIGVPGPEILFLSDVIEELDAAKRAGMRTALLDRREDYPTPRSADDVGSHQRVESFSQLVL
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: RL10_BURA4
Sequence: MPLNREDKQAVVAEVAAQVAKAQTVVLAEYRGIAVGDLTKLRAQAREKQVYLRVLKNTLARRAVEGTPFAPLAEQMTGPLIYGISEDAIAAAKVVNDFSKSNDKLVIKAGSFDGKVMDKAGVQALASIPSREELLSKLLFVMQSPVSGFARALAALAEKKQAEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: ATP8_COTJA
Sequence: MPQLNPAPWFMIMLMTWFTYSLLIQPKLLSFTSMNTPSNKTTSTTKPTPWTWPWT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: Y1580_ENTFA
Sequence: MLSKEKIARINELANKAKVEELSAKEKVEQQELRKEYLEAFRGGMRHHIEGMKVVDQEGTDVTPEKLKKIQREKGLHNRK
What are the official names of this protein?
UPF0291 protein EF_1580.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGAA_RALSP
Sequence: MELVVEPLNLHLNAETGSTLLDVLRSNEVPISYSCMSGRCGTCRCRVIAGHLRDNGPETGRPQAGKGTYVLACQAVLTEDCTIEIPESDEIVVHPARIVKGTVTAIDEATHDIRRLRIKLAKPLEFSPGQYATVQFTPECVRPYSMAGLPSDAEMEFQIRAVPGGHVSNYVFNELSVGASVRISGPLGTAYLRRTHTGPMLCVGGGTGLAPVLSIVRGALESGMSNPIHLYFGVRSEQDIYDEERLHALAARFPNLKVNVVVATGPAGPGRRSGLVTDLIGRDLPNLAGWRAYLCGAPAMVEALNLLVARLGIVPGHIHADAFYPSGV
What is the function of this protein?
Component of two multicomponent enzyme systems which are involved in the catabolism of naphthalene (PubMed:9573207, PubMed:11872705).  Plays a role as an electron transfer component for both salicylate 5-hydroxylase (S5H) and naphthalene 1,2-dioxygenase (NDO) systems, by transferring electrons from NAD(P)H to the oxygenase component via the ferredoxin NagAb (PubMed:9573207, PubMed:11872705).  The electron transport chain from the two systems can use both NADH and NADPH as electron donors at approximately similar rates (PubMed:11872705).
What are the official names of this protein?
Naphthalene 1,2-dioxygenase/salicylate 5-hydroxylase systems, ferredoxin--NAD(P)(+), reductase component, NDO/S5H systems, ferredoxin--NAD(P)(+), reductase component, Ferredoxin reductase NagAa, Ferredoxin--NAD(P)(+) reductase (naphthalene dioxygenase/salicylate 5-hydroxylase ferredoxin-specific).
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family.
Protein: RL15_BUCAT
Sequence: MRLNTLSPANGARHSRKRLGRGIGSGFGKTSGRGHKGQKSRSGSSIRRGFEGGQMPLYRRLPKFGFNSRKKNITTEVRLSDLSNLSTNIIDLNVLKQENIIKKNIKYAKIILSGKLTVPLIIRGLLVSKGARSEIENTGGKVEG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RUVB_CHLAB
Sequence: MTHQVSVLHQDKKFDVSLRPKGLKEFCGQAQLTERLELFLNAAIQRGEVPGHCLFFGPPGLGKTSLAHIVANTVGKGLLVASGPQLVKPSDLLGLLTSLQEGDVFFIDEIHRMGKVAEEYLYSAMEDYKIDITIDSGPGARSVSVDLAPFSLVGATTRSGMLSEPLRARFSFTGRVAYYSDEDLATILRRSSNLLGIDADASALYEIARRSRGTPRLANNLLRWVRDFAQMREGNCINSDVAEKALAMLLIDEWGLNEIDIKLLTTIMNYYQGGPVGIKTLSVAVGEDVRTLEDVYEPFLILKGLLKKTSRGRMVTQLAYNHLKRCSDNLQSLGEEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: NS1_HBOC1
Sequence: MAFNPPVIRAFSQPAFTYVFKFPYPQWKEKEWLLHALLAHGTEQSMIQLRNCAPHPDEDIIRDDLLISLEDRHFGAVLCKAVYMATTTLMSHKQRNMFPRCDIIVQSELGEKNLHCHIIVGGEGLSKRNAKSSCAQFYGLILAEIIQRCKSLLATRPFEPEEADIFHTLKKAEREAWGGVTGGNMQILQYRDRRGDLHAQTVDPLRFFKNYLLPKNRCISSYSKPDVCTSPDNWFILAEKTYSHTLINGLPLPEHYRKNYHATLDNEVIPGPQTMAYGGRGPWEHLPEVGDQRLAASSVSTTYKPNKKEKLMLNLLDKCKELNLLVYEDLVANCPELLLMLEGQPGGARLIEQVLGMHHINVCSNFTALTYLFHLHPVTSLDSDNKALQLLLIQGYNPLAVGHALCCVLNKQFGKQNTVCFYGPASTGKTNMAKAIVQGIRLYGCVNHLNKGFVFNDCRQRLVVWWEECLMHQDWVEPAKCILGGTECRIDVKHRDSVLLTQTPVIISTNHDIYAVVGGNSVSHVHAAPLKERVIQLNFMKQLPQTFGEITATEIAALLQWCFNEYDCTLTGFKQKWNLDKIPNSFPLGVLCPTHSQDFTLHENGYCTDCGGYLPHSADNSMYTDRASETSTGDITPSDLGDSDGEDTEPETSQVDYCPPKKRRLTAPASPPNSPASSVSTITFFNTWHAQPRDEDELREYERQASLLQKKRESRKRGEEETLADNSSQEQEPQPDPTQWGERLGFISSGTPNQPPIVLHCFEDLRPSDEDEGEYIGEKRQ
What is the function of this protein?
Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication.  Also plays a role in viral packaging and transactivation of several promoters.  Binds site-specifically to 2-3 approximate tandem copies within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR).  Becomes covalently attached to the 5' end of the nick and provides a 3'OH for priming DNA synthesis.  The helicase activity unwinds DNA in a 3'-5' direction on the longer strand.  Participates in the transcriptional regulation of several promoters.
What are the official names of this protein?
Initiator protein NS1, NS1, Non-structural protein 1, Non-structural protein NS1.
What is the protein family that this protein belongs to?
Belongs to the parvoviruses initiator protein NS1 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: LSPA_BACSU
Sequence: MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHRNTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFIDRAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PTH_STRPS
Sequence: MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIQHIGTHVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGILQSVDKVDDSVNYYLQEKNFEKTMQRYNG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRK_HUMAN
Sequence: MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR
What is the function of this protein?
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation.  Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4.  May function as a tumor suppressor.
What are the official names of this protein?
Tyrosine-protein kinase FRK, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
Protein: CORT_HUMAN
Sequence: MPLSPGLLLLLLSGATATAALPLEGGPTGRDSEHMQEAAGIRKSSLLTFLAWWFEWTSQASAGPLIGEEAREVARRQEGAPPQQSARRDRMPCRNFFWKTFSSCK
What is the function of this protein?
Binds to all human somatostatin receptor (SSTR) subtypes.  It also inhibits cAMP production induced by forskolin through SSTRs.
What are the official names of this protein?
Cortistatin.
What is the protein family that this protein belongs to?
Belongs to the somatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MDTA_ESCF3
Sequence: MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNESQSAAPGATKQAQQSPAGGRRGMRSGPLAPVQAATAVEQAVPRYLTGLGTITAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPSQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTFKADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLLFTLPESDITTVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQDDALFPNQFVNARMLVDTEQNAVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQKVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPEEKATSREYAKKGARS
What is the function of this protein?
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtA, Multidrug transporter MdtA.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: APOA1_TUPBE
Sequence: MKAVVLTLAVLFLTGSQARHFWQQDEPQSSWDRVRDLANVYVDAVKESGREYVSQLEASALGKQLNLKLVDNWDTLGSTFQKVHEHLGPVAQEFWEKLEKETEELRREINKDLEDVRQKTQPFLDEIQKKWQEDLERYRQKVEPLSAQLREGARQKLMELQEQVTPLGEDLRDSVRAYADTLRTQLAPYSEQMRKTLGARLEAIKEGGSASLAEYHAKASEQLSALGEKAKPVLEDIHQGLMPMWESFKTGVLNVIDEAAKKLTA
What is the function of this protein?
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).  As part of the SPAP complex, activates spermatozoa motility (By similarity).
What are the official names of this protein?
Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: HPSE1_ARATH
Sequence: MGFRVCVIVVFLGCLLLVPEKTMAQEMKRASIVIQGARRVCETDENFVCATLDWWPHDKCNYDQCPWGYSSVINMDLTRPLLTKAIKAFKPLRIRIGGSLQDQVIYDVGNLKTPCRPFQKMNSGLFGFSKGCLHMKRWDELNSFLTATGAVVTFGLNALRGRHKLRGKAWGGAWDHINTQDFLNYTVSKGYVIDSWEFGNELSGSGVGASVSAELYGKDLIVLKDVINKVYKNSWLHKPILVAPGGFYEQQWYTKLLEISGPSVVDVVTHHIYNLGSGNDPALVKKIMDPSYLSQVSKTFKDVNQTIQEHGPWASPWVGESGGAYNSGGRHVSDTFIDSFWYLDQLGMSARHNTKVYCRQTLVGGFYGLLEKGTFVPNPDYYSALLWHRLMGKGVLAVQTDGPPQLRVYAHCSKGRAGVTLLLINLSNQSDFTVSVSNGINVVLNAESRKKKSLLDTLKRPFSWIGSKASDGYLNREEYHLTPENGVLRSKTMVLNGKSLKPTATGDIPSLEPVLRSVNSPLNVLPLSMSFIVLPNFDASACS
What is the function of this protein?
Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme.  Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans (By similarity).
What are the official names of this protein?
Heparanase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 79 family.
What are the subcellular locations of this protein?
Lysosome membrane; Peripheral membrane protein. Secreted.
Protein: NCAP_RABVD
Sequence: MDADKIVFKVNNQVVSLKPEIIVDQYEYKYPAIKDLKKPCITLGKAPDLNKAYKSALSSMNAVKLDPDDDCSYLAAAMEFFEGTCPEDWTSYGMLIARNRDKITPYSLVEIKRTDVEGNWALTGGMEMTRDPTGSEHTSLVGLLVSLYRLSKISGQNTGNYKTNIADRIEQIFETAPFVKLVEHHTLMTTHKMCANWNTIPNFRVLAGTYDLFFSRIEHLYSAIRVGTVVTAYEDCSGLVSFTGFIKQINLTAREAILYFFHKNFEEEIRRMLEGRQETAVPHSYFIHFRSLGLSGKSPYSSNAVGHLFNLIHFVGCYMGQIRSLNSTVIAACAPHEMSVLGGYLGDEFFGRGTFERRFFRDEKELQEYEAAELTKTDVALADDGTVNSDDEDYFSGEARGPEAVYARIMMNGGRLKRSHIRRYVSVSSNHQARPNSFAEFLNKTYSSDS
What is the function of this protein?
Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases.  If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA.  Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation.  The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace.  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication.  Protein N binds protein P in the NC through a different interaction, and can be phosphorylated.  Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N.  During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
What are the official names of this protein?
Nucleoprotein, NP, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: TRMB_ENTFA
Sequence: MRVRNRPGAAEYMAKYPQYVVEGPEKWQGKWQERFGNNHPIHIEIGSGKGRFIYEMAKAHPEINYIGIDMQLSILSIALDKLVADPLPNLQLLRVDGEALTEYFAENEVDLIYLNFSDPWPKKKHEKRRLTYKNFLATDEIILKPNGEIHFKTDNQGLFEYSLSSFSKYGMIIERVWLDLHNSEFEGNIMTEYEEKFSSRGQRIYRVEARFVAK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: MNTP_ECOL5
Sequence: MNITATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGMGMLASRFVLEWNHWIAFVLLIFLGGRMIIEGFRGADDEDEEPRRRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGSIIGKKAEILGGLVLIGIGVQILWTHFHG
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Probable manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATI1D_ALYOB
Sequence: GLKDIFKAGLGSLVKNIAAHVAN
What is the function of this protein?
Antibacterial peptide with amphipathic alpha-helical structure.  Shows selective growth inhibitory activity against the Gram-negative bacteria E. coli (MIC=25 uM) Has a weak hemolytic activity against human erythrocytes (LC(50)>100 uM).  Is very weakly active against S. aureus (MIC=200 uM).
What are the official names of this protein?
Alyteserin-1d.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Alyteserin-1 subfamily.