PharMolix/UniProtQA huggingface dataset:
Protein: PSB2_DESA1
Sequence: MREAVSKTTTVGLVTGDYVVLAADKRATAGPMVYHKAVKKISKITDYAALTISGLVADAQYIVENARYIAREYEIEMGGPIPIKALASRISLILSVYLRYSPFIVQLLLGGRDSTGASLYYMDLYGSVTREKYMATGSGSPVAFGILEKNYRSDLSLEEAKKLAFNAVSSAIMRDGFSGEGVDIVVIGPGIYSEETIPLKKTIESS
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 2, 20S proteasome beta subunit 2, Proteasome core protein PsmB 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSDC1_HUMAN
Sequence: MAEGEDVGWWRSWLQQSYQAVKEKSSEALEFMKRDLTEFTQVVQHDTACTIAATASVVKEKLATEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVITLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRAEQSISEEPGWEEEEEELMGISPISPKEAKVPVAKISTFPEGEPGPQSPCEENLVTSVEPPAEVTPSESSESISLVTQIANPATAPEARVLPKDLSQKLLEASLEEQGLAVDVGETGPSPPIHSKPLTPAGHTGGPEPRPPARVETLREEAPTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWE
What are the official names of this protein?
BSD domain-containing protein 1.
Protein: PDXS_METLZ
Sequence: MTENRSKLNKELAQMLKGGVIMDVTSPEQAKIAEDAGACAVMALERIPADIRAAGGVSRMSDPKMIKGIQNAVSIPVMAKVRIGHFVEAQILEAIEIDYIDESEVLSPADDLNHIDKNKFNVPFVCGARDLGEALRRVAEGATMIRTKGEAGTGDIVQAVRHMRTMNSEIRRVVSLRQDELYVAAKDMQVPISLLQFVHDNGKLPVVNFAAGGVATPADAALMMQLGAEGVFVGSGIFKSGNPAKRAAAVVKAVTNYNNPSMLAELSEDLGEAMVGINADEISILMAERGK
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: SPE_SEPOF
Sequence: ARSFSSYCVRCRRKTPSFNSKTVTFRNKRRAIRSHCAYCQVKKFRIIGHGG
What are the official names of this protein?
Epididymal sperm protein E.
What are the subcellular locations of this protein?
Nucleus.
Protein: CFAD_MOUSE
Sequence: MHSSVYFVALVILGAAVCAAQPRGRILGGQEAAAHARPYMASVQVNGTHVCGGTLLDEQWVLSAAHCMDGVTDDDSVQVLLGAHSLSAPEPYKRWYDVQSVVPHPGSRPDSLEDDLILFKLSQNASLGPHVRPLPLQYEDKEVEPGTLCDVAGWGVVTHAGRRPDVLHQLRVSIMNRTTCNLRTYHDGVVTINMMCAESNRRDTCRGDSGSPLVCGDAVEGVVTWGSRVCGNGKKPGVYTRVSSYRMWIENITNGNMTS
What is the function of this protein?
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway.  Its function is homologous to that of C1s in the classical pathway.
What are the official names of this protein?
Complement factor D, 28 kDa adipocyte protein, Adipsin, C3 convertase activator, Properdin factor D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HLYS3_HYDVD
Sequence: MGKELLTFSDLRWLDSSPDTVRSAFTREYGTTPDGIALNSEGYFGYHSPPITEQYGRPCYKQTGETKITSQDLSAPTDDVLGSSAAINRGDSPITLTFGVEGVFQMGGEFSLTVSVRKSGSSSVEKTSTSSVQVTVPPRSKVVVSMVGIMKKEKVFFEVPVTVDGSFGANFSSTVQGHYFWFMDARSCLNKTSGVIKGTIDHANVFDVSVEVGPSEPL
What is the function of this protein?
Does not induce flaccid paralysis when injected into blowfly larvae and lacks hemolytic activity.
What are the official names of this protein?
Hydralysin-3.
What is the protein family that this protein belongs to?
Belongs to the hydralysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENO_BRASB
Sequence: MTAIVDIIGREILDSRGNPTVEVDVVLEDGSVGRAAVPSGASTGAHEAVELRDGDKHRYLGKGVLKAVEAINDEIYEALSDMSVQDQVQIDQILIELDGTPNKSRIGANAILGVSLACAKAAAISYDMPLYRYVGGTSARTLPVPMMNIVNGGVHADNPIDFQEFMIMPVGAPSFAEALRCGSEIFHTLKGELKKAGHNTNVGDEGGFAPNLPSADAALDFVMSAIGKAGYNAGEDVMLALDCAATEFFRDGKYVYEGENKSRSRSEQARYLADLVARYPIVSIEDGMSEDDMDGWKELTDLIGSKCQLVGDDLFVTNVNRLADGIRNGRANSILIKVNQIGTLTETLAAVEMAYKAGYTAVMSHRSGETEDSTIADLAVATNCGQIKTGSLARADRTAKYNQLLRIEQELDAQARYAGRSALKALA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RS10_NAUPA
Sequence: MEKIRIKLQAYDHRVLDKAVSIITDAIKRTGAEVKGPIPLPTKIRRYTVLRSPHINKDSREQFEIRIHRRIVDVVNASPETVDQLMKLELAPEVDVEVRALS
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: GSA2_LISW6
Sequence: MDHSMSKKLHDEALLHIVGGVNSPSRSNKGVGGGIPVTMERANGAYFYDVDGNKYIDYLAAFGPIITGHAHPHITEAITKAAQNGVLYGTPTKHEITFAKMLKEAIPSLEKVRFTNSGTEAVMTTIRVARAYTGRDKIIKFAGCYHGHFDLVLVEAGSGPSTLGIPDSAGVTKSTAEEVITVPFNDLASFKEALATWGNQVAAVLVEPIVGNFGMVEPAEGFLEAINELAHENGSLVIYDEVITAFRFMYGGAQNYLGVIPDLTAMGKIIGGGLPIGAYGGRIDIMEKVAPLGPAYQAGTHAGNPASILSGIACLEVLQEEGLYDRFQKYGSMLKDGIEKAAVKHGIAVTVNQIVGALTVYFTDEPVTNYAEAGATNGDLFGRFFKGMLEEGINLAPSKYEAWFITSAHSEADILETIQAVDTVFAKMVQDK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 2, GSA 2, Glutamate-1-semialdehyde aminotransferase 2, GSA-AT 2.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUKB_PASMU
Sequence: MSEELALENLEHVETSVPHTVFSHANSAPRGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAGFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLRPGVCYAALDTINSRNQRVIVGARLQQVAGRDKKVDIKTFSIQGLNLAENPTTIFTDVVNERQARVLTLNELKEKIEQAGAQFKQYHSITDYHAMMFDLGIIPKRLRSSSDRSKFYKLIEASLYGGISSAITRSLRDYLLPENLGVRKAFQDMESALRENRMTLEAIKVTQADRDLFKHLITETSNYVASDYMRHANERRGNIESAVRFRQDWYRARTEQHLSQQRLVELSREAAELAENEKTLEVDHQSAVDYLNLVLNALRHQEKIARYQDDVAEITARLEEQKMVVETATEQLEESQVQVEQVEQEVDQIRAQLADYQQALDAQQTRALQYQQAIAALEKAKTLCGLADLGVKNVEAYHDEFAAHAESLTEQVLELEQRMSISDAAKSQFDKAYQLVCKVAGEIPRSTAFEQAKVLLRDYPTQKVQAQQTSQLRAKLHELEQRYAQQQSAVRLLKEFNQRANVSLEDAEALEAYHAEQEALLEDVSAELSEQVEQRSTLRQKREQLSALYQDNAKKAPAWLTAQAALERLQDQSGETFADSQDVMQFMQAQLVKERELTIERDQLEQQRQQLEAQISRLSQPDGSEDARLNVLAERFGGVLLSELYDDVPIEDAPYFSALYGPARHAIVVRDLDAVKGQLAQLEECPDDLYLIEGDPTAFDDSVLSAQELAHGVVVQVSDRELRYSKFPEIPLFGRAAREQYLEALQQQRDDVTEQHAQRAFDVQKCQRLHEHFSQFVGLHLALAFQPNPEDVMAEIQQQRNEIERELNQFVTTEQQLRIQLDYAKEKMQLLNKLIPQLNLIADESLIDRVEECREQLDIAEQDELFIRQYGATLSQLEPIANTLQSDPEHYERLKADYEQAISQQKQVQQRLFALADVLQRKAHFAYEERVQTENTDLNEQLRAKLDSLQQQREVQKAQLQQKQQQFTNYNRVYIELQTSFNNKMQMLQELLQEVGELGVRADQGAEERAKQRRDELHQVLSDTRQRRHYVEKQLTLIESEAQSLNARIRKAERDYKTQRELVVAAKVSWCVVMRLSRGSDVEKRLNRREFAYLSADELRSMSDKALGALRTAVADNEYLRDSLRLSEDNRKPENKVRFFIAVYQHLRERIRQDIIKTDDPIDAIEQMEIELSRLTDELTRREQKLAISSESVANIMRKTIQREQNRIRMLNQGLQNIAFGQVKSVRLVVNIRDTHAMLLDALSGTQEEYQDLFTDQRMTFSEAIAKLYQRLNPHIDMGQRTAQTIGEELLDYRNYLDLEVEVYRGADGWLRAESGALSTGEAIGTGMSILLMVVQSWEEESRRIRGKDIVPCRLLFLDEAARLDAKSISTLFELCERLDMQLLIAAPENISPEKGTTYKLVRKIAGNQEHVHVVGLRGFGATA
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: RS19_LARHH
Sequence: MARSIKKGPFVDLHLLKKVDAARSSNDKRPIKTWSRRSTILPDFVGMTIAVHNGRTHVPVYVTENMVGHKLGEFSLTRTFKGHAADKKAKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: PPK1_XANP2
Sequence: MNEAAALAEVEIPAGAAEVLALAQSPQRFINREISWLHFNRRVLEEAENRNHPLLEQLRFLSISANNLDEFFMVRVAGLKEQVREGVQTPSPDGLTPSEQLATILASAAQLISDQQGRWLELRHDLAGVGIVLVDGVEVTAEDLVVLDRHFLNHVFPVLTPLAIDPAHPFPFIPNLGFSLALQLVRQADGRGMNALIRIPAKVERFIRLPDLGTGALRFITLEQMIGLFISRLFPGYAVKGQGVFRVVRDSDLEIEEEAEDLVRLFETALKQRRYGEVIRMEADAAMPAELRNFVARELGVNDDEIFVVGGVLALNEFSQLVSVDRPDLKFQAYNARFPERIRDHGGDCFLAIREKDILVHHPYESFDVVVQFLRQAARDPNVVAIKQTLYRTSSDSPIVKALAEAAEAGKSVTALVELKARFDEEANIRWARDLERAGVQVVFGFIELKTHGKLSMAVRREGAQLATYVHVGTGNYHPITARIYTDLSFFTADPVIAQDVARIFNFITGYATPGELDAMAVSPTGLKPRLLNHIADEIEFAKAGRPAAIWLKCNSLVDPEIIDALYEASAAGVQVDCIIRGICCLRPGIPGLSENIRVKSIVGRFLEHSRVYCFGAGHGLPSPNAVVYISSADLMPRNLDRRVETLCPITNPTVHEQVLDQIMVANLIDNQQSWRVLPDGSSERIVPAPGEEPFNAHQYFMTNPSLSGRGKSLKDSSPRSLFVRR
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: DXR_ACIF5
Sequence: MTRGICILGATGSIGKSTLDVVSRHPDQFRIVALTGNHRVAEMQLLCQQHHPELVVMAAPEAAQQLRVGLGDAGLKKIQVESGPEALAEAARMSGVDEVMAAIVGAAGLLPTLAAVEAGKKVYLANKECLVMAGNLFMERVRQHQVTLLPIDSEHNAVFQCFADGKGVRRILLTASGGPFRTWPAEHLAVVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFDLPASRIDVMIHPQSIIHSMVEYVDGSVLAQLGNPDMRTPIAHALAFPERMESGVSSLDLAHGPDLQFEAPDLQRFPCLALAFDALQAGGAAATVLNAANEIAVQAFLEGHLPFLRIAAVVEDTLGELQPAAPDHLDDVLAIDQLAREVALRHLARHGSGMQ
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: RS13_CHLPD
Sequence: MRIAGVNLPLNKHAVIALTHVYGIGKTSAKSILQRAGIAPERKISELNDEEAHAIREIIAEDYKVEGQARGEQQLAVKRLMDIGCYRGLRHRRSLPVRGQRTQTNARTRKGKRKTVAGKKKATKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: PUR7_ECO7I
Sequence: MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRTAGSLVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RL6_LIMF3
Sequence: MSRIGYKEIDLPAGVEVSQEGNVVTVKGPKGTLSREISPLITMSVEGNVVKFERSGEDNKVRALHGTTRANVNNMVEGVVNGFKKTLKLVGVGYRAQFKGDKLILTVGYSNPVEMTKPAEVEIAVPDNTTIEISGIDKQEVGDFAAEVRAVRSPEPYKGKGIRYENEHIVRNEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ZONAD_KOMPC
Sequence: MKFAISTLLIILQAAAVFAAFPISDITVVSERTDASTAYLSDWFVVSFVFSTAGSDETIAGDATIEVSIPNELEFVQYPDSVDPSVSEFFTTAGVQVLSTAFDYDSHVLTFTFSDPGQVITDLEGVVFFTLKLSEQFTESASPGQHTFDFETSDQTYSPSVDLVALDRSQPIKLSNAVTGGVEWFVDIPGAFGDITNIDISTVQTPGTFDCSEVKYAVGSSLNEFGDFTPQDRTTFFSNSSSGEWIPITPASGLPVESFECGDGTISLSFAGELADDEVLRVSFLSNLADDVLEVQNVVNVDLTTADSRKRALTSFVLDEPFYRASRTDTAAFEAFAAVPADGDITSTSTAITSVTATVTHTTVTSVCYVCAETPVTVTYTAPVITNPIYYTTKVHVCNVCAETPITYTVTIPCETDEYAPAKPTGTEGEKIVTVITKEGGDKYTKTYEEVTYTKTYPKGGHEDHIVTVKTKEGGEKVTKTYEEVTYTKGPEIVTVVTKEGGEKVTTTYHDVPEVVTVITKEGGEKVTTTYPATYPATYTEGHSAGVPTSASTPPQATYTVSEAQVNLGSKSAVGLLAIVPMLFLAI
What is the function of this protein?
Putative adhesion protein.  May be involved in cell-cell interaction, interacting with other proteins by salt bridges and hydrogen bonds.
What are the official names of this protein?
Putative adhesin, Zonadhesin.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Identified as covalently-linked GPI-modified cell wall protein (GPI-CWP) in the outer cell wall layer.
Protein: NDK_RICFE
Sequence: MTIQYTFSMIKPDAIKRNKIGQVNTYLENAGLKIVAQKMKFLTKYEAECFYDEHRARPFFNSLVEYITSGAVVLQVLKGEDAIILNRTIMGATNPAEAEAGTIRKDLGESIEANSIHGSDSENSAKREIEFFFNKSEIIE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNC_ECOSM
Sequence: MFEIHPVKKVSVVIPVYNEQESLPELIRRTTKACESLGKEYEILLIDDGSSDNSAHMLVEASQAEGSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYM_BACTN
Sequence: MEKKFKRTTVTSALPYANGPVHIGHLAGVYVPADIYVRYLRLKKEDVLFIGGSDEHGVPITIRAKKEGVTPQDVVDRYHYLIKKSFEEFGVSFDVYSRTTSKTHHELASDFFKTLYNKGEFIEKTSEQYYDEEAKTFLADRYITGECPHCHSEGAYGDQCEKCGTSLSPTDLINPKSAISGSKPVMKETKHWYLPLDKHEGWLRQWILEDHKEWRPNVYGQCKSWLDMGLQPRAVSRDLDWGIPVPVEGAEGKVLYVWFDAPIGYISNTKELLPDSWETWWKDPETRLLHFIGKDNIVFHCIVFPAMLKAEGSYILPDNVPSNEFLNLEGDKISTSRNWAVWLHEYLEDFPGKQDVLRYVLTANAPETKDNDFTWKDFQARNNNELVAVYGNFVNRAMVLTQKYFDSKVPACAELTDYDKETLKEFANVKAEVEKLLDVFKFRDAQKEAMNLARIGNKYLADTEPWKLAKTDMERVGTILNISLQLVANLAIAFEPFLPFSSEKLRKMLNMESFEWSELGRNDLLPVGHQLNKPELLFEKIEDSVIEAQVQKLLDTKKANEEANYKANPIRPNIEFDDFTKLDIRVGTILECQKVPKADKLLQFKIDDGLETRTIVSGIAKHYQPEELVGKQVCFIANLAPRKLKGIVSEGMILSAENNDGSLAVIMPQKEVKPGSEVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_MYCSS
Sequence: MTVTPSGSNGAGSAAPEGRKLLRLEVRNAQTPIERKPPWIKTRARMGPEYKELKSLVKREGLHTVCEEAGCPNIFECWEDREATFLIGGEQCTRRCDFCQIDTGKPSELDRDEPRRVAESVQAMGLRYSTVTGVARDDLPDGGAWLYAETVREIKRLNPNTGVELLIPDFNGDPALLAQVFESRPEVLAHNVETVPRIFKRIRPAFRYERSLAVLTAARDDNLVTKSNLILGMGETPDEVRTALVDLHEAGCDIITITQYLRPSPRHHPVERWVKPEEFVEFAQFAEGLGFAGVLSGPLVRSSYRAGRLYAQAARLKPAATPPVS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BMI1_MOUSE
Sequence: MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADEEKRIITDDEIISLSIEFFDQSRLDRKVNKEKPKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRMKMSHQRDGLTNAGELESDSGSDKANSPAGGVPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSNSPSANHQSSFASRPRKSSLNGSSATSSG
What is the function of this protein?
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.  The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A.  In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).
What are the official names of this protein?
Polycomb complex protein BMI-1, Polycomb group RING finger protein 4.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ADT1_MAIZE
Sequence: MADQANQPTVLHKLGGQFHLRSIISEGVRARNICPSVSSYERRFATRNYMTQSLWGPSMSVSGGINVPVMQTPLCANAPAEKGGKNFMIDFMMGGVSAAVSKTAAAPIERVKLLIQNQDEMIKSGRLSEPYKGIVDCFKRTIKDEGFSSLWRGNTANVIRYFPTQALNFAFKDYFKRLFNFKKDRDGYWKWFAGNLASGGAAGASSLFFVYSLDYARTRLANDAKAAKGGGERQFNGLVDVYRKTLKSDGIAGLYRGFNISCVGIIVYRGLYFGLYDSIKPVVLTGNLQDNFFASFALGWLITNGAGLASYPIDTVRRRMMMTSGEAVKYKSSLDAFQQILKKEGPKSLFKGAGANILRAIAGAGVLSGYDQLQILFFGKKYGSGGA
What is the function of this protein?
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).  Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
What are the official names of this protein?
ADP,ATP carrier protein 1, mitochondrial, ADP/ATP translocase 1, Adenine nucleotide translocator 1, ANT 1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SMC_BORPD
Sequence: MRLTQLKLAGFKSFVDPTVIPVPSQLVGVVGPNGCGKSNIIDAVRWVLGEAKASELRGESMQDVIFNGSGNRKPAARASVEMVFDNSEGRAAGQWSTYSEIAVRRVLTRDGTSSYYVNNQQVRRRDIHDIFLGTGLGARGYAIIGQGMINRLIEARPEELRVFLEEAAGVSRYKERRRETENRLSDTRENLTRVEDILRELGSQLEKLEAQAEVARQYRELQADGEKKQFALWLLKETGARDERQRKSQEMAQAQTNLEAAIANLRSGEAELESRRQAHYAAGDAVHAAQGQLYEANAQVSRLEAEIRHVVDSRNRLQARREQLQQQIAEWDAQQTHCVEQIAQAEDDLATGAARTEEARALAEEAHASLPAVEARVRDAAASRDEMRSSLARVEQNLALAAQTQRDADRQLQNLEQRRERLQQELRELHAPDPVRLEQLAGDRAAGEDQLEEAQQELAALEARVPEADAERSRAQAAAQQDAQNLARLEARLAALVKLQEDVQKQGALEPWLAKHELAGLGRLWQKLHIEPGWENALEAVLRERMAALEVRNLDWSRAFAEDAPPARLAFYQMPAAAPTPAAPQGLTPLASLLRITDPDLRTLLNDWLGNIYTAPDLGQALAARATLPAGAACVVPAGHLVDAHSVRFYAPDSEQAGLLARQQEIENLQREIKAQQLIADQARAAVARAESAWQQVSQAVAPARQRVAEITRRVHDIQLEHSRLQQQAEQSGERAARLRQDLEEISAHEEDLRATREEAEARFEALDAELAEHQSRFADAEIAGEDLAAQAEAARARLRELERAAQEAEFAERGVQSRIADLQRNRQLAADQSQRAAVELEQLQADLADLDASASQAGLQDALEVRAEREEALSRARQELDNLSALLRGADEERMQQERALEPLRARITELQLQEQAARLAEEQFTEQLNAREVDREALAQELAAMPDEWRRANWLQSEVGRISRQIDSLGSVNLAALDELNASRERKEFLDSQQQDLLTAIDTLEDAIRKIDRETRELLQATFDTVNGHFGELFPKLFGGGEAKLTMTGDEILDAGVQVMAQPPGKRNSTIHLLSGGEKALTATALVFALFKLNPAPFCLLDEVDAPLDDANTERYANLVSSMSEQTQFLFISHNKIAMQMAKQLVGVTMQEQGVSRIVAVDIDSAVQMAAEAA
What is the function of this protein?
Required for chromosome condensation and partitioning.
What are the official names of this protein?
Chromosome partition protein Smc.
What is the protein family that this protein belongs to?
Belongs to the SMC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA_ECOSE
Sequence: MQENQQITKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHVLPEYLEKLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIQRFADAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVNGGDLAFDREEIPLQPAGWQPEEDENQLDELRLNVVEVK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PBP1_TRYB2
Sequence: MEGSHSSNMERLEYLYLNLVGQVVQVRLVDDMCVEGLFVACTDVDAETDAGIMICCTRNLASAKRSPLSPSCVNFTDDLFIPYQSIVMIEVQNAKIRTETPGRPDTGRADFSATKFDWADDGVSELLESEPHQTGTWNQFEANEKSFGVKTTYKEEFYTTRLDHSKITEEQRAQADRLAREIESSSTRGIAHRMEREECLHDDEGLDEGQLYSDVHRPQEKKPPYVPPSTGGRKLVNEPPPVPAAAAPATAPTTAPAAAPAPAAAPPAAAPAAAAPPPPPAATSMADDGSMRHKRMNEDPHHMQYDANQTAAGFNPAAAPYTPMKPGAAVPVVDFLASLADAISNNDMCYDCEPHWPGMCNLFYDQDDSSYSQQNYEAAAMPPSHSMNMHMYVNSQPNIPNAHRGYQGPLGRVPHNQSMPMHHMQGQGFHHEMHHHQAFHGMGNYSSQHHNPPIQEYAPHKGQQGVVSRPGMRQGKGGGASRVEPQQPVSANTASSPPPVPTVDSAPNEVKPPAKLQRGRGMAAFTKGDMDGDSGATTNATGGPKKRVGK
What is the function of this protein?
Involved in post-transcriptional regulation of gene expression (PubMed:24470144).  Promotes mRNA stabilization by bridging poly(A)-binding protein to mRNAs (PubMed:24470144).
What are the official names of this protein?
PAB1-binding protein 1, Ataxin-2 homolog, Poly(A)-binding protein-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ataxin-2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, Stress granule. Note=Localizes to polysomes (PubMed:24470144). Localizes to starvation-induced stress granules but not heat shock-induced stress granules (PubMed:24470144).