PharMolix/UniProtQA huggingface dataset:
Protein: HPX2_CAEEL
Sequence: MNLKPTILLFTILFLKCATFEVNEETERIVEDAVMRALDSRASENSESEQTSQHIIVSQQANSDSKSAQFTGEVLEEATRILVREFGLEILPAANEVIERWRNEEEELLQSSETTTTTEHPDPTRSKRSAIFRSKRQANRRCSSPPINCNNRFHTSIRSITGLCNNRQNSDLGNSVSPLRRILGAASYADGLGRIRTRSVNGGELPSARLISNRIHDDRNNQVFSPSINHLHMIIGQFIAHDVVFMPSSVARDGGALDCSACNSPQRVSPNCAPITIPRNDPYFNTPCMRLTRALNGQENFGVRSQIGQNSHFLDLSPVYGSADCEAETVRSFQEGKMLTFDDLGYTLPPQNANDSNCQSSAPFHCFTCGDFRNSLHPALIPVHTILIKEHNRLAEQVRVARPRFNDEQIFQLVRKIMIGMWQHIVYNEYIPKYLPRRTIRNFALRPLRNGVHRGYSTSVDPSISAEFAGAAFRFGHSQSRFDFPRLTENGRPAGNYDLGNDIFYADQMYLTRIGGWEPVMNGMVRMPAMKSDRYFSFGIRNQMFEIRGRNGSGVDLVSINIQRGRDMGLFPYIQYRQLVGLPTVTSFNELNTTFSQENIQALRNVYSDPADIDLYVGIMLEEPLSGGQLGPTASFMIGEQFRALKRGDRFFYESIAEGTDNFTQEEISELRNKTSLAKIICTNMDFAARINTDIFDHRSRQVACTSLPQLDIDRFLR
What is the function of this protein?
Peroxidase which is involved in maintaining the cuticle integrity in the hypodermis and pharynx (PubMed:30695063).  It thus plays a role in conferring resistance against Gram-positive bacteria such as E. faecalis, S. aureus and C. diphtheriae, and yeast such as C. albicans (PubMed:24621828, PubMed:30695063).
What are the official names of this protein?
Heme peroxidase 2.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROB_GEOSM
Sequence: MIAEKIRVALDERSYDIEMGAGNLDRIGSLCREVGLSGTAAVVSNTTVAPLYYETVRLSMERAGYRVVPVTLPDGEGYKNSATLNLIYDGLVDASLDRGSFILALGGGVIGDMAGFAAASYLRGIPFVQIPTTLLSQVDSSVGGKTGINHPRGKNLIGSFYQPKAVLIDVATLDTLPEREFLSGLGEIVKYGAVLDGGFFDFLEQNAKLLLARDKEALIQAVSRSCAIKAKVVAEDEREGGVRAVLNFGHTLGHAVETLTGYTRYLHGEAVAIGMVQAARISQHYGFCSQADRERIEALIVALGLPIELPIFPAQQYREALSHDKKVRDKGLLFICNQGIGAYRMERLTDLGALLEICGIGE
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A4GAT_RAT
Sequence: MGISRSDLEETMSKPPDCLPRMLRGTPRQRVFTLFIISFKFTFLVSILIYWHTVGAPKDQRRQYSLPVDFPCPQLAFPRVSAPGNIFFLETSDRTNPSFLFMCSVESAARAHPESQVVVLMKGLPRDTTAWPRNLGISLLSCFPNVQIRPLDLQELFEDTPLAAWYLEAQHRWEPYLLPVLSDASRIALLWKFGGIYLDTDFIVLKNLRNLTNMLGIQSRYVLNGAFLAFERKHEFLALCIRDFVAHYNGWIWGHQGPQLLTRVFKKWCSIHSLKESRACRGVTALPPEAFYPIPWQNWKKYFEDVSPEELAQLLNATYAVHVWNKKSQGTHLEATSRALLAQLHARYCPTTHRAMTMYL
What is the function of this protein?
Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)) (PubMed:10854428).  Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (By similarity).  Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (By similarity).
What are the official names of this protein?
Lactosylceramide 4-alpha-galactosyltransferase, Alpha-1,4-N-acetylglucosaminyltransferase, Alpha-1,4-galactosyltransferase, Alpha4Gal-T1, Globotriaosylceramide synthase, Gb3 synthase, UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 32 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: EX7L_BARBK
Sequence: MADFFTEKPVATNVAEFSVSEIANALKRVVEDKFGYVRIRGEISGYRGAHASGHAYFALKDDKARLEAVIWLSVMKKLSFPPEEGMEVIAVGKLTTYPGSSKYQIVIEALEPTGVGALMTLLENRKKKLAEEGLFDAANKKPLPYMPKIIGVVTSPTGAVIRDIIHRIFDRFPLHILVWPVRVQGETCGREVASAVEGFNALFLGGGIPKPDLIIVARGGGSLEDLWGFNDEAVVRAVYASAIPVISAVGHETDWTLIDYAADWRAPTPTGAAERAVPVKLDIEVHLASINSRFRVGLARYFDFHQQKLRALVRGLPTVDQLFALPRRGFDEISSRLQRALCVSYDKKCFYFHALSLRFSPRLLNTKKAQYAIQEYTGRLHRAFLRNVEKQRAQVEMACRLLKSTSYQNILERGFVLALGKDHKPIKRLMQLPETGQISLRFFDGEIDVSTHDRAVNRSLKNKRIKSQKDDQGLLF
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGB_ENTFA
Sequence: MQIIRVANAEEGGKKAFELIKEGMNNGAKVLGLATGSTPETLYKEMTASDVDFTEMTSVNLDEYVGLGGEDEQSYRYFMNKHLFDKKPFKETFVPNGKAEDLDAASAEYEKIIDAHPVDIQILGIGQNGHIGFNEPGTPLDSLTHVVELTESTINANKRYFDKVEDVPTRAVSMGIGSIMKGKKMILMAYGEAKAEAIKGMIDGPVTTDMPASALQNHQDVVVIIDDAAASKL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: RS24_PYRAB
Sequence: MEIKITEVKENKLIGRKEIYFEIYHPGEPTPSRKDVKGKLVAMLDLNPETTVIQYIRSYFGSYKSKGYAKYYYDKDRMLYIEPEYILIRDGIIEKKEGE
What are the official names of this protein?
30S ribosomal protein S24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: SYGB_OLEA2
Sequence: MSVFVMEIGTEELPARFLSGLEQEIASRFEAALAAANVEFGTLNVQSTPRRLALTIENIDAVQREAEEVVSGPPVRIAFDAQGRPTKAAEGFARTQGAELDELFTLTTDKGEYLAVRKKTGGRPVQEILSEVAPEIIAALPFPKKMKWGSGDFTFGRPLRWVLALFDSEVVSFTVAGIVSGNETCGHRVHGPGPFEVSGADAYAGTVRDKCHVTLCAADRRRVTVEGGDALAAQAGGRILWKDSLLDEVQGLCEHPVPCLGDFDPSFLELPAEVLLTSMESHQKSFGVAAADGSLMPHFLTVLNMTPQNSALVKKGWERVLRARLEDARFFWKADLASDFDSWLAKLDNVIFLAPLGSMGDKTRRLERLCRWLAAAVAPDIQEQAARAGRLSKADLVSEMVYEFDSLQGIMGGIYARRKGEDEIVAQAVSEQYLPAGPESPVPDSLCGALLSIADKADTLAGCFGLSMIPTGAADPYALRRCALGIARIMLEKGLRFDVRELFRYAQEGYGERQWKLKPEQAAEKLHEFFVLRLKNLFVSQGHETLLVEAALHAGADDVWAAGARLEALDRFSKSAEFGQAVLTFKRAANIIRKQGQEEDGGLDGCYDASLFEDEAEKALAGALEDIAPDFEARWAADDYHALFGLLGVLRPAVDAFFDSVMVMCEDPHIRRNRLNLLQSLVQRLGRLADFGALQM
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPP_STRP2
Sequence: MSLQKLENSSNKSVVQEEVLILTELLEDITKNMLAPETFEKIIQLKELSTQEDYQGLNRLVTSLSNDEMVYISRYFSILPLLINISEDVDLAYEINHQNNIDQDYLGKLSTTIKLVAEKENAVEILEHLNVVPVLTAHPTQVQRKSMLDLTNHIHSLLRKYRDVKLGLINKDKWYNDLRRYIEIIMQTDMIREKKLKVTNEITNAMEYYNSSFLKAVPHLTTEYKRLAQAHGLNLKQAKPITMGMWIGGDRDGNPFVTAKTLKQSALTQCEVIMNYYDKKIYQLYREFSLSTSIVNVSKQVREMARQSKDNSIYREKELYRRALFDIQSKIQATKTYLIEDEEVGTRYETANDFYKDLIAIRDSLLENKGESLISGDFVELLQAVEIFGFYLASIDMRQDSSVYEACVAELLKSAGIHSRYSELSEEEKCDLLLKELEEDPRILSATHAEKSELLAKELAIFKTARVLKDKLGDDVIRQTIISHATSLSDMLELAILLKEVGLVDTERARVQIVPLFETIEDLDHSEETMRKYLSLSLAKKWIDSRNNYQEIMLGYSDSNKDGGYLSSCWTLYKAQQQLTAIGDEFGVKVTFFHGRGGTVGRGGGPTYEAITSQPLKSIKDRIRLTEQGEVIGNKYGNKDAAYYNLEMLVSAAINRMITQKKSDTNTPNRYEAIMDQVVDRSYDIYRDLVFGNEHFYDYFFESSPIKAISSFNIGSRPAARKTITEIGGLRAIPWVFSWSQSRVMFPGWYGVGSSFKEFINKNPENIAILRDMYQNWPFFQSLLSNVDMVLSKSNMNIAFEYAKLCEDEQVKAIYETILNEWQVTKNVILAIEGHDELLADNPYLKASLDYRMPYFNILNYIQLELIKRQRRGELSSDQERLIHITINGIATGLRNSG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: RS14_PSEPG
Sequence: MAKKSMKNRELKRQLTVAKFAKKRAELKATIVNVNASPEERFAAVVALQKQPRDASAARLRNRCRLTGRPHGVYRKFGLGRNMLRQAAMRGDVPGLVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: Y083_MYCPN
Sequence: MVKVWKIGFGVFLPTALLFSACSFKDYIPTPSFRKDFSTENNFVKNKVPGKDDIYSKFYDLTFSLNFVNNQAQEFGTGWLIDWKGDENKNLSKNKEGQTASQTRSSSEQTTDQDANLFTAYIATNLHVADGLKNDQDYAPYNKDGWGQPYPYQQKTQSFLLGKYTKPNVQLVKTNYEKPEDAVIEQKLKEDSLLFIQTSTLPKTAYAAIDPVNFSYNPTRTNGFWTAGKYNVYNGGNSIGNYADFAVIEVPLVLSNPNDAKIYQEWIRPATQAYKYLGDVEGLFAKKGYRSYIQDFYHLLGYPVTKNTKSEFILGQSQGTVNHMSFSNDESNTTNTITKASLTQQPHKEQSAYVVRESGLPTLTMNVDKYTGAKGTHLVNVDQITDLSLGDGLIDFGGLSRFILQYHNVNYKQFGYGTILWDTNFGGGSSGSAIFNQNKQINSIYFGALVNVTTDRNENVGLGLGQILRAPNTFNSSHEVPYSYDLIFGDVNTTNFYAQFAKKHNTHMWSKIQSTQNGEIGFHKNSKTGQQRH
What are the official names of this protein?
Uncharacterized lipoprotein MPN_083.
What is the protein family that this protein belongs to?
Belongs to the MG067/MG068/MG395 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: VATA_STAMF
Sequence: MSLGITGKIYRVSGPLVIAENMRGSKVYEVVEVGSDRLIGEIIGVEGDKAIIQVYEDTSGLRVGDPVYGTGYPLAAELGPGLVGSIYDGIQRPLPLLQELVGFFVKRGVKAKPLPRNKKWHFKPLVKQGEKVGPDDVIGYVEETPVIKHYIMIPPDTHGVVEEIVGEGEYTIVDPIARINGKEIVMLQKWPVRKPRPYREKLEHREPVLTGQRVIDFFFPLAKGGKAAIPGGFGTGKTVTLQQLTKWSAVDIAIYVGCGERGNEMADALHSFRRLVDPRTGKALVERSVFIANTSNMPVAARETSIFLGATIGEYFRDMGYHVLMVADSTSRWAEAMREISGRLEELPGEEGYPAYLGSRLASFYERSGYVKTLGRPDRTGSLTIMGAVSPPGADFSEPVTQATLRIVRALYALDVNLAYRRHYPAINWLISYSLYVDNVTDWWHKNIDPSWRELREKALAILQKEAELEELVRLVGAEALPEEDKLLLEVARMIREDFLQQNAFHEIDTYCPPRKAVLMMKAIMLFYELGLEAIKRGISMEKIRELKSRVKIARMKEIPNIDFEDAFKSLFEDIRRDFESLMKEAETIAEL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: KATG_ECOLI
Sequence: MSTSDDIHNTTATGKCPFHQGGHDQSAGAGTTTRDWWPNQLRVDLLNQHSNRSNPLGEDFDYRKEFSKLDYYGLKKDLKALLTESQPWWPADWGSYAGLFIRMAWHGAGTYRSIDGRGGAGRGQQRFAPLNSWPDNVSLDKARRLLWPIKQKYGQKISWADLFILAGNVALENSGFRTFGFGAGREDVWEPDLDVNWGDEKAWLTHRHPEALAKAPLGATEMGLIYVNPEGPDHSGEPLSAAAAIRATFGNMGMNDEETVALIAGGHTLGKTHGAGPTSNVGPDPEAAPIEEQGLGWASTYGSGVGADAITSGLEVVWTQTPTQWSNYFFENLFKYEWVQTRSPAGAIQFEAVDAPEIIPDPFDPSKKRKPTMLVTDLTLRFDPEFEKISRRFLNDPQAFNEAFARAWFKLTHRDMGPKSRYIGPEVPKEDLIWQDPLPQPIYNPTEQDIIDLKFAIADSGLSVSELVSVAWASASTFRGGDKRGGANGARLALMPQRDWDVNAAAVRALPVLEKIQKESGKASLADIIVLAGVVGVEKAASAAGLSIHVPFAPGRVDARQDQTDIEMFELLEPIADGFRNYRARLDVSTTESLLIDKAQQLTLTAPEMTALVGGMRVLGANFDGSKNGVFTDRVGVLSNDFFVNLLDMRYEWKATDESKELFEGRDRETGEVKFTASRADLVFGSNSVLRAVAEVYASSDAHEKFVKDFVAAWVKVMNLDRFDLL
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.  Also displays NADH oxidase, INH lyase and isonicotinoyl-NAD synthase activities.
What are the official names of this protein?
Catalase-peroxidase, CP, Hydroperoxidase I, HPI, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: RS28_HALLT
Sequence: MSAEEGTGDSTTAEVIEVVGKTGMHGEAMQVKCRIQEGSNQGRIITRNVLGPVRMGDVLQLRETQRDADSIGGR
What are the official names of this protein?
30S ribosomal protein S28e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS28 family.
Protein: RSMH_BURVG
Sequence: MGNELQHRTVLLDEAVDSLVTRPDGIYVDGTFGRGGHSRAVLARLAPGGRLIAFDKDPRAIETAQRIEDARFSIVHDSFASMRDALAARGVEKVSGVLLDLGVSSPQVDDPARGFSFRADGPLDMRMDPTRGESAAEWLARASVQELTEVIRDYGEERFAFQIAKALVARRAESDRLGPLDTTGELAQIVGHVVKTREKGKDPATRTFQAIRIHVNQELADLQVVLDAALSLLEQGGRLVVISFHSLEDRIVKRFMQAHASAPAVDRRLPIRAVDLPSPPLKIISRQFPSEAEVAANPRARSAVMRIAERVTP
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPTS_STAAM
Sequence: MTAYKPYRHQLRRSLFASTIFPVFLVIIIGLVSFYAIYIWIEHRTIHQHVDESQSSLHHTEKQIQTFITQHNNSFQELDLTNHHDVTATKRELLKLIHQQPATLYYELSGPNQFITNNYEHLNTKNMYLFSTHQLKFNNSTYMLKIYMANTPRLSEIKKDSRQFALIVDQYDNILYANDDRFTIGEKYRPQQFGFMNESVKLNHADHRLIIYKDIHENIEDGITLLIVMAVVLVLLVIFGFISADNMAKRQTKDIETIIQKIYYAKNRHLGTYTPLKNNSELEEINNYIYDLFESNEQLIHSIEHTERRLRDIQLKEIERQFQPHFLFNTMQTIQYLITLSPKLAQTVVQQLSQMLRYSLRTNSHTVELNEELNYIEQYVAIQNIRFDDMIKLHIESSEEARHQTIGKMMLQPLIENAIKHGRDTESLDITIRLTLARQNLHVLVCDNGIGMSSSRLQYVRQSLNNDVFDTKHLGLNHLHNKAMIQYGSHARLHIFSKRNQGTLICYKIPLSRGNVDV
What is the function of this protein?
Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources.  May act as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of HptS.  In turn, HptS antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility.
What are the official names of this protein?
Sensor protein kinase HptS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MP2K1_CRIGR
Sequence: MPKKKPTPIQLNPTPDGSAVNGTSSAETNLEALQKKLEELELEEQQRNRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGVFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPAKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLLVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
What is the function of this protein?
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation.  RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2.  Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade.  Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).  Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements.  One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis.  MAP2K1/MEK1 has been shown to export PPARG from the nucleus.  The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis (By similarity).
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Nucleus. Membrane; Peripheral membrane protein. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis. Membrane localization is probably regulated by its interaction with KSR1.
Protein: RNH2_GEOTN
Sequence: MKQYTVKEIEALLPELEGESDPRWEMLRRDERKSVQALLARFVKQKEREKAARQRWEELMRYERELYAAGIERIAGIDEAGRGPLAGPVVAAAVILPKDAYLPGLDDSKRLTPAKREALFAQIEECAVAIGVGIVSAAEIDEWNIYEATKQAMAKAVAALSPSPEHLLVDAMTVPCALPQQRLIKGDANSASIAAASIIAKVTRDRWMHELDRRYPQYGFARHMGYGTPEHLAAIRRYGVTDEHRRSFAPVREALGVQS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_IDILO
Sequence: MTQRVRIATRKSKLALWQAEHIQQRLEELHPGLSVELVPMSTKGDVILDTPLAKIGGKGLFVKELEVAMLEGRADIAVHSMKDLPVEFPPGLELHTICEREDPRDAFVSNNYKNLNELPEGAVVGTCSLRRRCQVKEQFPHLVIKDLRGNVQTRLRKLDEGEFDAIILAASGLIRLELGDRITSFIPVEQSLPANGQGALGIECRSDDDEMKALLAPLQCQETRTRVLAERAMNRGLDGGCQVPIGAYAELEGDEVYLRGLVGEPDGGKVLRDEVRGPASKAEELGSELAERLLKQGAAEILSAVYDSESSHS
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CAH1_BOVIN
Sequence: MASPDWGYDGENGPEHWGKLYPIANGNNQSPIDIKTSETKRDPSLKPLSVSYNPATAKEIVNVGHSFHVNFEDSDNRSVLKGGPLSESYRLRQFHFHWGITDDCGSEHLVDGAKFSAELHLVHWNSAKYPSFADAASQADGLALIGVLVKVGQANPNLQKVLDALKAVKNKNKKAPFTNFDPSVLLPPSLDYWAYSGSLTHPPLHESVTWIIFKETISVSSEQLAQFRSLLANAEGDREVHIKQNNRPPQPLNGRTVKASF
What is the function of this protein?
Catalyzes the reversible hydration of carbon dioxide.
What are the official names of this protein?
Carbonic anhydrase 1, Carbonate dehydratase I, Carbonic anhydrase I, CA-I.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_NITEC
Sequence: MVRNVVVIGTQWGDEGKGKIVDWLTDRAAGVIRFQGGHNAGHTLVVNGEKTVLHLIPSGILRKDVICYIGNGVVLSPGALLDEMSMLEQAGVDVSGRLRISEACPLILPYHIAVDGARELAKGPEKIGTTGRGIGPAYEDKIARRAIRLQDLFYPERFASKLKEVLDYHNFLLKNYYHTATVDYDQILDECLKKAERIQPMVADVPKLLFEANKAGNNLLFEGAQGALLDIDHGTYPFVTSSNCIAGAASVGSGVGPQLLGYVLGITKAYTTRVGSGPFPTELADTTGEYLAQRGNEFGSTTGRPRRCGWFDAVATRRSIQINGVSGLCITKLDVLDGLEKLKICTGYKSKQSDRLYDALPFGADDLADIEPVYEELPGWQACTAGIKDFDQLPKTAQNYLKRIEEVCQTPISMISTGPDRIETIVFHHPFG
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_RICPU
Sequence: MLRFKELYQQKIIENLQKNFSYKNKHEIPQIKKIVINMGVGEATADSKVINNAVNDLTLISGQKPVVTLARKSIATFKLRENMKIGCKVTLRKDRMYDFLERLVIVALPRVKEFRGFSYKSFDGKGNFTFGLKEQIVFPEINYDKIDTIRGMDITIVTSAKTDQESKFLLSGFNLPFYN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: HIS62_PROMM
Sequence: MLKKRLIPKLQFSIKPSYRGPKPVLVITRQFDSKRAIGDPVSQAKIYEAQLADELVLVDLEGTSDSWPILLDTLSNMSESLATPLSVGGGITSFEQVQQLLDRGADKVVLNSGAVNNPQLIDLVANSYGSQCVVISIDIRKESDLSRHVYIDGGSTATDWSLFSWANDCASRGAGELLITSIDNDGTGTGLDLDSIRQLRYEVNLPLIASGGCGLAQHFVAGYEVGASAVAAGTFFSQRDQNPMQCRSHIRNAGLPIRLEQ
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
What are the official names of this protein?
Putative imidazole glycerol phosphate synthase subunit hisF2, IGP synthase cyclase subunit, IGP synthase subunit hisF2, ImGP synthase subunit hisF2, IGPS subunit hisF2.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_ANOGA
Sequence: MGIDINHKWDRKVRRTRPKSLDVYLSLLVKLYRFLYRRTKKKFNKIVMRRLFMSRTNHPPMSLNRVAHLMKLRGKDEKSVAVVIGTVTNDVRMMDVPKLNVCALRVTDKARQRILKNGGKIYTFDQLALLSPTGRNTVLMQGKRTAREVFKHFGRAPGVPHSNTRPYVQSKGRKFEKARGRRSSCGYKN
What are the official names of this protein?
60S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL18 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_PSEPF
Sequence: MARYIGPKCKLARREGTDLFLKSGVRAIESKCNIEAAPGIHGQRRGRQSDYGTQLREKQKVRRIYGVLERQFSGYYKAAASKKGATGENLLQLLECRLDNVVYRMGFGSTRAESRQLVSHKSISVNGQTVNVPSYQVRAGDVVAVREKAKNQLRIVQALELCAQRGRVEWVEVDAEKKSGVFKNVPARSDLSADINESLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PROX1_CHICK
Sequence: MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKPNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDVCSNSSRDSPQECLSPFGRPTMSQFDVDRLCDEHLRAKRARVENIIRGMSHSPRVALRGNENEREIRPQSVSPRESYRENKRKQNWPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEEFYQIYDSTDSENDEDGNLSEDRMRSETVDAQAGDSVGRSDNEMCELDPGQFIDRARALIREQEIGENKPKREGPKEKDQGPNSFHPEGKHLAETLKQELNTAMSQVVDTVVKVFSSKPSRQLPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFSSVPMPGATDQTDALPLVVRKNSSDQPASAPPAGGHHASLHQSPLSATAGFSTSSFRHPFPLPLMAYPFQSPLGAPSASFPGKERASPESLDLTRETTSLRTKMSSHHMNHHPCSPAHPPSAAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
What is the function of this protein?
Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs.  May be essential in the development and function of the eye.  May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes.
What are the official names of this protein?
Prospero homeobox protein 1, Homeobox prospero-like protein PROX1, PROX-1.
What is the protein family that this protein belongs to?
Belongs to the Prospero homeodomain family.
What are the subcellular locations of this protein?
Nucleus.