PharMolix/UniProtQA huggingface dataset:
Protein: TDCC_SALCH
Sequence: MSTTDSIVSSQAKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLQMPALNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLSNIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYEKEFGREFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANHFASLSGTKSTFATVLEYGASIIALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSMGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTLIGLLTILNIVYKLF
What is the function of this protein?
Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Threonine/serine transporter TdcC, H(+)/threonine-serine symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RBP9X_DROME
Sequence: MENVEEAPPLSSESNSNSNNSSASSSSHQLSQSGAMGAEIAPSTSRSHSHSPTPSPPVPASSHDQPHPDHPSPPLNASETEARENSPHDHSPTPTFHQTAPPPTTSSTAPQRDEREQQQQQEAPPLQQDQQENSPAQDQELHPLLDQQNQEYPAVHQDQQAEQNQELHHIEGLIRHRESQNPEEHPPQASLENRETLGREDTNQEPDEPQVRDPEIEPEAEPPPPLLLEDLDEQDSGSQDLNEQQPPLIIDANAIAETIDANAVERIDDYEDDDEEVDEEEEVVEDRVDRAGEVASVSGAQRLHSVAVLPRYSSASRAPRSSNNNNNNISNHNNNNNNSNSNSLSRRTRHFYSNNGSHFSNDMFPSHNPRSSTQTSSPRVGGRRHHSTPAASSNSPQHQGVDPLRLLYPNVNESETPLPRCWSPHDKCLSIGLSQNNLRVTYKGVGKQHSDAASVRTAYPIPSSCGLYYFEVRIISKGRNGYMGIGLTAQQFRMNRLPGWDKQSYGYHGDDGNSFSSSGNGQTYGPTFTTGDVIGCCVNFVNNTCFYTKNGVDLGIAFRDLPTKLYPTVGLQTPGEEVDANFGQEPFKFDKIVDMMKEMRSNVLRKIDRYPHLLETPENLMNRLVSTYLVHNAFSKTAEAFNGYTNQTFNEDLASIKTRQKIIKLILTGKMSQAIEHTLRSFPGLLENNKNLWFALKCRQFIEMINGADIENVNNKVTATTQTMPTNQTSVIQSTKTFKHSKSGSGNGNVNINQTQQQNNTAIPAVIKPQGGDRPDIKNMLVDDNSNKCVEHDSNSMDVEMEPCQSHSNGGDSSSNGNASAVRNSLDAIDEEMDVDVSPSSRNCGRVIEKILEFGKELSSMGQQLEKENLMTEEERQMLEDAFSLIAYSNPWSSPLGWLLCPSRRESVSTTLNSAILESLNFERRPPLEYLVAHASELIKVIGQHSLGEDAFITIDDVFPQN
What is the function of this protein?
May be involved in JAK/STAT signaling.  Isoform D is required for the proper arrangement of niche cells and is autonomously required for proper niche cell size, isoform C negatively regulates the adhesive properties of the niche.  The germline stem cell (GSC) niche in ovaries is made up of two somatic cell types: 8-9 cells in a single-filed array make up the terminal filament (TF), and a tight cluster of 5 or 6 cap cells (CpC).  Regulating the size and adhesive properties of the CpCs is an important component of the mechanism that controls their capacity to support stem cells, isoform C and isoform D are important factors in mediating this regulation.  In contrast, isoform C acts as a positive regulator of cell adhesion in follicle cell epithelium.
What are the official names of this protein?
Ran-binding proteins 9/10 homolog, Ran-binding protein M.
What is the protein family that this protein belongs to?
Belongs to the RANBP9/10 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Nucleus. Note=Distribution varies depending on cell type and developmental stage. At late embryogenesis expression is enriched in the nuclei of follicle cells and germline cells and at the nurse cell membranes. In pupal ovaries, expression is seen in niche cells at the cell periphery. In adult ovaries expression is in the nuclei and cytoplasm of the CpCs and TF cells of the niche.
Protein: MSCL_CROS8
Sequence: MSFFKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFALTLRPAVGDTPAVIMHYGVFIQNVFDFVIVAFAIFLAIKVINKLHQKKPKEAPGPSKEEVLLTEIRDLLKQQNEHRP
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSRP_MAGMM
Sequence: MTFRLIAENRKARFNYEIIEKIEAGIVLQGTEVKSIRAGKMTLADSYAVVNREELYWLNGQIAHYEHGNIHNHEPFRSRKLLLRHKEISRLIGLVKEKGLSIIPLRAYWKGSKVKLELGIAKGKKLYDKRATTKERDWQREKQRILKTNH
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PYRR_STRP3
Sequence: MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVFLARRIQERLHQLEGLDLPIGELDIKPFRDDMRVEEDTTLMSVDITGKDVILIDDVLYTGRTIRAAIDNLVSLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSSVEEIVVEVVEVDGRDRVSIIDPT
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: HJM79_ENTHR
Sequence: MKKKVLKHCVILGILGTCLAGIGTGIKVDAATYYGNGLYCNKEKCWVDWNQAKGEIGKIIVNGWVNHGPWAPRR
What is the function of this protein?
Bacteriocin with antibacterial activity against the Gram-positive Listeria, Enterococcus, Propionibacterium, Staphylococcus and some strains of Clostridium, Lactobacillus and Pediococcus.  Lacks antibacterial activity against Gram-negative bacteria.
What are the official names of this protein?
Bacteriocin hiracin-JM79, Class II sec-dependent bacteriocin.
What is the protein family that this protein belongs to?
Belongs to the bacteriocin class IIA/YGNGV family.
What are the subcellular locations of this protein?
Secreted.
Protein: XERC_NITWN
Sequence: MAKRAEPLPDPACAASDIGQQIVRWLTHLRAERRLSPKTLEAYARDVRQCLMFLGQHWSEQVTLEGFVALEPADIRSFMAARRADDIGGRSLMRSLAGLRSFARFLEREGLGKVGALGAIRAPKVGKSVPKPIHMSAAKRFADASERAGEDREPWIWARDAAVMALLYGSGLRISEALGLKRRDVPPPGAGDVLVVTGKGNKTRMVPVLQNVLALIHEYVAMCPHSLPPEGPIFVGARGGPLRARIIQLVMARMRGALGLPDSATPHALRHSFATHLLSRGGDLRAIQELLGHASLSTTQIYTGIDSERLLDVYRTAHPRA
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXO4_MOUSE
Sequence: MDPENKKSATGAAAILDLDPDFEPQSRPRSCTWPLPRPDLATEPHEPSEVEPSLGQKVPTEGHSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRAASMDSSSKLLRGRSKGPKKKPSVLPAPPEGATPRSPLGHFAKWSSSPCPRNREEADVWTTFRPRSSSNASTVSTRLSPMRPESEVLAEEEMPASASSYAGGVPPTLSEDLELLDGLNLASPHSLLSRSGLSGFSLQHPGLAGPLHSYGASLFGPIDGSLSAGEGCFSSSQSLEALLTSDTPPPPADVLMTQVDPILSQAPTLLLLGGMPSSSKLGTGVSLCPTPLEGPGPSNLVPNLSVMAPPPVMAGAPIPKVLGTPVLASPTEDSSHDRMPQDLDLDMYMENLECDMDNIISDLMDGEGLDFNFEPDP
What is the function of this protein?
Transcription factor involved in the regulation of the insulin signaling pathway.  Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.  Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes.  Also involved in negative regulation of the cell cycle.  Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity (By similarity).  Represses smooth muscle cell differentiation by inhibiting the transcriptional coactivator activity of myocardin.
What are the official names of this protein?
Forkhead box protein O4, Afxh, Fork head domain transcription factor AFX1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm (By similarity).
Protein: WDR4_MOUSE
Sequence: MASSAGLALCAQTLVVRGGSRFLAFSTTGSDDDCVFTYDCSTAEKKATPEDKGEDGQPADTGSDSILASTFSKSGRYFALTDDSKRLILFRTKPWQCLSVRMVVRRCTALTFTASEDRVLVADKSGDVYSFSVLEPDGCGRLELGHLSMLLDVAVSPDDQFVLTADRDEKIRVSWAAAPHSIESFCLGHTEFVSRILVVPSHPELLLSSSGDGTLRLWEYRSGRQLQCCDLAGLQEPGEQPGHKGLAASRIAFWGQESYVVLLCECVPVVFVFQLDASRQQLVFRQRLTFPHRVWDVVFEEARGLWVLQDCRDAPLVLWRPVGGEWQAAPDGAVSPRLCSHLRESWAMLEGSVGTDDSFRSLYKATFDNMTSYLKKKEERLQQQLKKKRQRSPFPGSPEQTKKACPGQSALSC
What is the function of this protein?
Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:29983320).  In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding (By similarity).  Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:29983320).  M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (By similarity).  Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (By similarity).  Also required for methylation of a specific subset of miRNAs, such as let-7 (By similarity).  Acts as a regulator of embryonic stem cell self-renewal and differentiation (PubMed:29983320).  Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:29574139).
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, Protein Wuho homolog, mWH, WD repeat-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TRM82 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes at the site of nascent DNA synthesis.
Protein: RL2_CANAL
Sequence: MGRVIRNQRKGAGSIFTSHTRLRKGAAKLRTLDYAERHGYIRGVVKQIIHDPGRGAPLAKVAFRDPYKYKLREETFIANEGVYTGQFIYAGKKASLNVGNILPLGACPEGTIVSNVEEKVGDRGALGRTSGNYVIIIGHNPDENKTRVKLPSGAKKIISSDARGVIGVVAGGGRIDKPLLKAGRAFHKYKVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAARRTGLLRGTQKTAE
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: HTF_BLEDI
Sequence: QVNFSPGWGT
What is the function of this protein?
Hypertrehalosaemic factors are neuropeptides that elevate the level of trehalose in the hemolymph (trehalose is the major carbohydrate in the hemolymph of insects).
What are the official names of this protein?
Hypertrehalosaemic factor, Adipokinetic hormone 1, BleDi-AKH-1, Hypertrehalosaemic neuropeptide.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: DFP_BOMMO
Sequence: MKVYACLCAAVVMLVMTSRVSEARSTGAPLSACRDMMPQHNATAQTSPPPYTITTDAQSVAPGDSVEVVIAGKLPEDTLRGYLLQARQGDDILGTFSLEDGDVFSQLINCGKPGNAVTHKKHDNKEDKRQVRVRWSPPQGLTGEVVFRATIVKTLKVFWVGVQSAPIKIVS
What is the function of this protein?
May have antimicrobial activity.
What are the official names of this protein?
Putative defense protein.
What is the protein family that this protein belongs to?
Belongs to the insect defense protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: SRP14_MACRA
Sequence: STVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKTKKTKAAAAAAAAAVAAAAAPTAAATTATPATPAATAAQ
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity).  SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity).  The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).
What are the official names of this protein?
Signal recognition particle 14 kDa protein, SRP14.
What is the protein family that this protein belongs to?
Belongs to the SRP14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_SHIDS
Sequence: MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYYWSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CH604_RHIEC
Sequence: MAAKEVKFSVEAREKMLRGVDILANAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQMVREVASKTSDIAGDGTTTATVLAQAIVKEGAKAVTSGMNPMDLKRGIDLAVSAIVEELKANARKISNNAEIAQVGTISANGDAEIGRFLAEAVQKVGNDGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNADKMRVEFEDPYILIHEKKLSNLQSMLPILEAVVQSGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTAGTVISEDLGIKLENVTLNMLGRAKKITVEKENTTIIDGVGSKEEISGRIAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALHATRAAVEEGILPGGGVALLRAVKALDNIKTANDDQRVGVEIVRRALEAPARQIAENAGAEGSVVVGKLREKSDFSYGWNAQTGEFGDLYAQGVIDPAKVVRTALQDASSIAGLLVTTEAMIAEKPKKDAPPAMPAGAGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 4, 60 kDa chaperonin 4, Chaperonin-60 4, Cpn60 4.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_DICNV
Sequence: MKSLGEFIIEKQAEYPQAKGSLSGILSAVRRAAKIINRDINRAGVVSDLVLGSMGRENVQGETQMKLDVFAHEAMKAAFYSRDDIAGFASEEEEEFTAFDTERGHNAKYIILMDPLDGSSNIDVNVSVGSIFSIYHRVTPIGTPVTLEDFLQPGHKQIAAGYIIYGSSTMLVFTTGNGVNGFTYDPSLGTFLLSHENIKIPKDGAIYSINEGGYLKFPQGIKKYIKYCQEDAPEEHRPYKSRYIGSLVADFHRNMLKGGVYMYPQASNYPNGKLRLSYECNPMAFIAEQAGGVATTGHERILDIQPQALHQRTPFIVGSEHMVNKIKDFIAQYPDN
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_YERPG
Sequence: MLQPKRTKFRKMHKGRNRGLAQGTDVSFGEFGLKACGRCRLTARQIEAARRAMTRAIKRQGKVWIRVFPDKPITEKPLEVRMGKGKGNVEYWVALIQPGKVLFEMAGVPEETAREAFKLAAAKLPVGTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: AROE_ACIBY
Sequence: MTKQFAVIGNPIEQSRSPELHHAFAEKTGVDLNYQKRLAPLDGFESSMRSFFAEGGSGMNVTVPFKEQAFALCDVLTERAQIAKAVNTLWMENGKLHGDNTDGQGLVAAIQALEWNLENTTILILGAGGATRGVIYPLVQAGAQKIVIANRTLARAEQLVDDLKTAVPQAQLQAISLNDLEGDFDIVINATSTSLSGDALQLPEKLQFKYAYEMAYGKPSSFIDQAKQRNVPYAEGFGMLVGQAIEAFYIWNGVRPQLKDFL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: GNAI2_ORYLA
Sequence: MGCTVSQEDKAAADRSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYRAVVYSNTVQSIMAIIKAMTILHLDYERPEREEDAKRLFKMAAEAEERGDLPEELANIIKDLWADSGIQHCLTRAREYQLNDSAAYYLKDLERISKPDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVAMSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEQKIAHSPLTICFPEYEGPNTYQEAQAYIQTKFEDLNKKKETKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.  May play a role in cell division (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-2, Adenylate cyclase-inhibiting G alpha protein, Gi alpha c, Gi2 subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane.
Protein: COX1_RICPR
Sequence: MNSLTNIEDLNCDNQHIPNGFRRWIFSTNHKDIGIMYIIFAIFAGVVGGLFSLLFRLELAMPGGTFLNHNFQLYNVLITVHAIIMVFFMIMPALFSGFGNYFVPLLIGAPDMAFPRLNNISFWLLIPAFLLLISSTFIDGGPGTGWTLYPPLSNLNGHTGAAVDVAIFSLHLTGLSSILGSINLIVTIFNMRTPGMGLFKMPLFVWSILVTAFLIILAMPVLSGAITMLLTDRNFGTTFFKPDGGGDPLLFQHLFWFFGHPEVYIVILPGFGIVSQVISTFSRKPIFGYQGMVGAMVIIGFVGFIVWAHHMFTVGLSYNALIYFTAGTMIIAVPTGIKIFSWIATMWGGSITFPTPMLFAIGFIILFTIGGVTGIILSNSALDRVLHDTYYVVAHFHYTMSLGALFTAFAGFYYWFGKISGKQYPEILGKIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPEAFAGWNMVSSIGAGISIFAAFYFVFIVFYTLKYGKNCTANPWGDGADTLEWKLNSPPPFHTFETPPHIVE
What is the function of this protein?
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Subunits 1-3 form the functional core of the enzyme complex.  CO I is the catalytic subunit of the enzyme.  Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
What are the official names of this protein?
Probable cytochrome c oxidase subunit 1, Cytochrome aa3 subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PLSX_YERPN
Sequence: MACLTLALDAMGGDFGPCVTVPASLQALASNPQLKLLLVGNPDTITPLLANADSLLLERLQVIPAEHVIASDAKPSQAIRASRGTSMRVALELVKNGEAAACVSAGNTGALMGLAKMMIKPLEGIARPALMTVIPNQRRSKTVVLDLGANVECDSTMLVQFAVMGSVMAEEVVGIVEPRVALLNIGEEENKGLDNIREAAAVLKNTPAINYIGYLEGNDLLTGKTDVMVCDGFVGNVTLKTMEGVIRMFLSLLKPSGEGSKQSWWLKLIGRWLQKRVAKRFGHLNPDQYNGACLLGLRGIVIKSHGAANQRAFAVAIEQAVQAVQRQVPERIAARLEAVLPKSD
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RUVB_EHRCJ
Sequence: MKNILQSTECLEDQQNVSIRPNLLDEFIGQSSVVNNLKIFINAAYTRKEPMDHVLLYGPPGLGKTTLAHIIAKELKVNFRSTAGPLLSKAGDLAAILTNLQAKDILFIDEIHRLNRNIEEILYSAMEDFCLDIIVGEGCGARTLRVDLPKFTLVGATTRIGLLSNPLRDRFGIPIHLEFYSTEELIKVIQRAAKVIKTDISDSGAQEISLRARGTPRIALRLLRRIRDFIEVTEHNKTITDTFADKALLRLGIDKLGLDRQDIQYLKFIHDSNNPTGIDTISSGLSEDTGNIEETIEPYLIKINFIQRTPRGRVITQKAISYLKEQSYI
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.