PharMolix/UniProtQA huggingface dataset:
Protein: UBI4P_KLULA
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGI
What is the function of this protein?
Ubiquitin exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Polyubiquitin.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BUP1_DICDI
Sequence: MSKQFESVQATLEKYIPAEELSEVKRILYGYNRGHHVKSLPICQEALDLANKNNFEIVASKVEADPEQLRKPRIVRLGIIQNSIGAETTAPIQDQYLAIEAKIEKMIDAAGAMGVNVLCLQETWHMPFAFCTREKYPWVEFAESASTGQSIKFIQRMARKYNMVIISPMLERDDVHASTIHNTAVVVGNNGNIIGKSRKNHIPRTGDFNESTYYMESTLGHPVFETIYGKIAINICYGRHHNLNWLAYGLNGAEIVFNPSATVGELSEPMWGVEARNAAMTNNYFVGSINRVGTEHFPNEFTSGNGKPAHKDFGHFYGSSYFSSPDNCCTPSLSRVSDGLNISEVDLNLCQQVKDKWNFQMTARYELYAKFLTDYINPNYQPNIIKDPSMK
What is the function of this protein?
Catalyzes a late step in pyrimidine degradation.  Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed:11454750).  Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (By similarity).
What are the official names of this protein?
Beta-ureidopropionase, Beta-alanine synthase, N-carbamoyl-beta-alanine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.
Protein: YO010_HUMAN
Sequence: MYVSISFLLGLSHLVLCCLLTFIVNFYLPPESIDFEFMAHNWSKGRSPSSTLGLSWFKAGFRFSDGWSMFYSFGLPGVALPGSPPRSHLLPGTQILIRSFQPCESAKHSARLSSLLTTTSYSVS
What are the official names of this protein?
Putative transmembrane protein FLJ36131.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PXPA_STAAE
Sequence: MRVDLNCDLGEAFGNYSFGGDHQIIPLITSANVACGFHAGDENVMNETVKLAKAHNVAVGAHPGLPDLKGFGRRNIDISNDEIYNLMIYQLGALQGFCRIHQVKINHVKPHGALYQMGAKDREIANVIAQAVYDFDPSLVLVGLANSYLISEAKNVGLITASEVFADRRYEDDGQLVSRKESDAVITDTDEALKQVLKMVKENKVISKNNKEVTLQADTICVHGDGEHALLFVSKIREILMKEGIDIQSL
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: SPB4_VANPO
Sequence: MSKSLLWDDLEYPIQPWIRSAVDVMGFENMTPVQAATIPLFARNKDVVVDSVTGSGKTVSFVIPIFEKIVQEEANTTKMKKGHFHSLIVSPTKELAKQIHSVFESFLEHYPENLYPIRSQLLVGTNVKTVRDDVSDFMENKPQILIGTPGRILDFLKIPSVKTSMCSMVILDEADRLLDVSFLKDMENIMNILPKQRRTGLFSATITSAGDNIFKTGLRNPVKVTVNSKSQAPSSLKIDCAVVETDKKLEQVISIINNYKFKKCIAYFPTCHSVTYFYSFMQYLLKKGIIKEEIQIYSLHGKLQTSARIKTLETFTETISNAVLLTTDVAARGIDIPDVDLVLQLDPPTDPEVFLHRCGRTGRANKLGKAITFLTPGREEDYIPFMEVKNINLEEISLDIVNLPDNFYEIFKDWLLEDRARLDQAVKSYVAYIKTYSKHAASSIFRLQSFDYVGLAKFYGLIRLPKMPEITKYFKEDKENARTFGEGWLIDPPINMDKFGYLDKKKEDRRLADLKNLKSIHDKKKLKSELKKKNMSWSNNTQSKEEKVERRTKMALKRKRIEEELSKEADENSSGDDEQNRDWKQVILQNKKSKNSNNGMQGSFDDL
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.  Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA.  Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5. 8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
What are the official names of this protein?
ATP-dependent rRNA helicase SPB4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GPMB_YERPB
Sequence: MLQVYLVRHGETLWNAARRIQGQSDSPLTEIGIRQAHLVAQRVRNQGITHIISSDLGRTQQTAKIIADACGLTMVTDPRLRELNMGVLENRPIDSLTPEEEQWRKQMVNGTEGARIPEGESMTELGRRMHAALDSCLELPAGSKPLLVSHGMALGCLLSTLLGLPAHAERRLRLRNCSLSRVDYQESPWLASGWVIESAGDTAHLDMPALDELQR
What are the official names of this protein?
Probable phosphoglycerate mutase GpmB, PGAM, Phosphoglyceromutase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. GpmB subfamily.
Protein: CLPX_LIMRD
Sequence: MFEDTTGMDSVHCSFCGKSQDEVKKIVAGPGVYICNECVDLCKQIIDQELAEDEAKKAFRVPTPGEIVNELDDYVIGQGDAKKTLAVAVYNHYKRVNAMMSGDNNDTELQKSNIAVIGPTGSGKTYLAQSLARILNVPFAIADATTLTEAGYVGEDVENIILKLLQAADFDVERAEKGIIYIDEIDKIAKKSENVSITRDVSGEGVQQALLKILEGTIANVPPQGGRKHPQQEFIQVDTKNILFIVGGAFDGIETIVKERLGDKTIGFGTDSREAEEVTDKNILQHVIPEDLLKFGLIPEFIGRLPVMTALEKLDEDDLVRILTEPKNALVKQYQELIRLDGSQLTFTDGALRAMAQLAIKRNTGARGLRSIIEDVMRDVMFDLPSRKDVEKVIIDKRCVTQHTEPRYVLKDEKAS
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: MURG_FLAPJ
Sequence: MEQYKFILSGGGTGGHIYPAIAIANELKSRFPNCKILFVGAKDKMEMQKVPQAGYDIKGLSIAGLQRKITLQNAMFPFKLLSSLVKSFGIVQQFKPDVVIGTGGFASGAVLKVASILGIATVIQEQNSYPGITNKLLSKKANKICVAYENLEQFFPKDKMILTGNPVRQDLISVDGKRNEAIDYFKLDANKKTILILGGSLGARRINQLIAKEIDWLLSQNVQIIWQCGKLYFEDYKPFSGKENVQILSFIDRMDLVYAAADIVISRSGASSVSELAIVGKPVIFIPSPNVAEDHQTKNAQAIVNKQGAILLKESQLDSEFKFVFESLLNDKAKQEDLSKNIKQLALPNATKDIVDEIIKLVESQKS
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YIDC_OLEA2
Sequence: MENKRPIIAVVLSLFVLIGWSYLSEFMGWTPAPAPVEQNATAVQQKASEPVAQPVQTASAPAASSFAPTEGREVKVDTPLYTAVFQSQGGVLKHFRLKKYTESIEEGAPLVELVTPEAAGKAPMGLLLNGQPTWKLAAWQFEGDDLKLDGSGKGELVFVGEMDGVRFERTLSFDPETYLISEKVRLTDTAGVSRDVRLGMTLSTTSLSPEGGAYNLTRMAWYQDGFHQETSADDLRETGVKVDEGVNWGGVMCNYFMAVMAPAEGALPFKGVLEGGVYRSVVENSSLSIASGSSAEFGIGYYIGPKESDRLAAMPYHLDEALNYGWFTFLAKPLVSGLKFFYSYAGNYGVAIIILTILVKLLFWPLSQKSYKSMEQMKKLQPMVQKIKEKYGDDRQRMNQEVMELYKTYKVNPAGGCLPMLLQIPVFLGLYQGLLNAIELRHAPFIAHLPFTDIVWLADLSAKDPFYITPVVMGATMLLQQRLTPAPADPTQAKIMMFMPVVFTFMFLNFPAGLVVYWLVNNVLSIGQQWWMLRKS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL15_PSEFS
Sequence: MKLNDLSPAPGSRREKHRPGRGIGSGLGKTGGRGHKGQTSRSGGTIAPGFEGGQQPLHRRLPKFGFVSLKAMDRAEVRLSELAKVEGDIVTVQTLKDANVINVNVQRVKIMLSGEVTRAVTIGKGIGATKGARSAIEAAGGKFEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ARGJ1_BOTFB
Sequence: MALNACTKLPVARLIRPSASYHPAISSIRYYSAPPESTIPAAKLKYIPTSGTYPKGFLVSGTHVGVKPTNKSTPDLAFLASETPCAAAAVFTKNKFQAAPVTVSRKMLQRRSNTGIRSVIINSGCANAVTGKGGMEDAEKMGAEADRCFDTPSDGKGGSSIVMSTGVIGQRLPIQKILLKIPTAFDGLGSSHEHWLATATAICTTDTFPKLLSRTFSLPSSPEVEYRMAGMTKGAGMIHPNMATLLGMIATDAPIAPTLLPSLLTKAVNKSFNSISIDGDTSTNDTVAVLANGAAGGKEVTSESSEDHAAFQKVLTEFATDLAKLVVRDGEGATKFVTIRVTEAPSEIGARKIASTIARSPLVKTALYGKDANWGRILCATGYSQISEPGQPINEVPEIIPEKTSVSFIPSDGSPELKLLVNGEPESVDEARAAEILEHEDLEILIKLGGGKEEAVYWTCDFSHEYVTINGDYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RL14_LACP3
Sequence: MIQQESRLKVADNSGAREILVIKVLGGSYRKTGNIGDVVVATVKQATPGGVVKKADVVKAVIVRTKSGARRADGSYIKFDENAAVIINADKSPRGTRIFGPVARELRDGDFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: UPPP1_BURPS
Sequence: MSLWFLVFLSVLQGVTELFPVSSLGHTLLVPALFGMHIDKHAPQLLPFLVALHLGTALALLWYFRERWIALIAGFFASLNGRKNDEGHLMWALIIGTIPTGLVGLLLEKRIERVFHDLRIVAAALIINGVLLWLGDRIQRARAHRPPEKLTFKQAFFVGLAQVGALIPGFSRSGLTMIAGNAAGLTADKAAEFSFLLGTPIIFAAGLLELPKLFHAPDQLADALLGGVLTAIAAYLSVRFLMRYFEGRGRLASFGLYCVLAGLFCLGWFMFHAQPV
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 1, Bacitracin resistance protein 1, Undecaprenyl pyrophosphate phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL24_BURTA
Sequence: MNKIRKGDEVIVITGKDKGKRGVVLAVGAEHVTVEGINLVKKHVKPNPMKGTTGGVEAKTMPLHISNVALVDANGKASRVGIKVEDGKKVRFLKTTGAVLSA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: KGD4_HUMAN
Sequence: MMGSKMASASRVVQVVKPHTPLIRFPDRRDNPKPNVSEALRSAGLPSHSSVISQHSKGSKSPDLLMYQGPPDTAEIIKTLPQKYRRKLVSQEEMEFIQRGGPE
What is the function of this protein?
May be necessary to recruit DLD/E3 to the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDC) core composed of OGDH/E1-DLST/E2, hence stabilizes the complex.
What are the official names of this protein?
Alpha-ketoglutarate dehydrogenase component 4.
Protein: RS3_RHIE6
Sequence: MGQKINPIGFRLGINRTWDSRWFADNAEYGQLLHEDLKMRKFVMSELKQAGISKVVIERPHKKCRVTIHSARPGLIIGRKGADIDKLRKKLSDMTNSETHLNIVEVRKPEVDATLVAQSIAQQLERRVAFRRAMKRAVQSAMRLGAEGIKITCAGRLGGAEIARTEWYREGRVPLHTLRADIDYGTAEAETAFGICGIKVWIFKGEILEHDPMASERRALEGDAQGPASRERDRGDRRRERDNA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: ENTH_ECOL6
Sequence: MIWKRHLTLDELNATSDNTMVAHLGIVYTRLGDDVLEAEMPVDTRTHQPFGLLHGGASAALAETLGSMAGFMMTRDGQCVVGTELNATHHRPVSEGKVRGVCQPLHLGRQNQSWEIVVFDEQGRRCCTCRLGTAVLG
What is the function of this protein?
Required for optimal enterobactin synthesis.  Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.
What are the official names of this protein?
Proofreading thioesterase EntH, Enterobactin synthase component H.
What is the protein family that this protein belongs to?
Belongs to the thioesterase PaaI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_CLONN
Sequence: MKLFNTMTRQKEEFKPIKDGEVSMYVCGPTVYNYFHIGNGRTFLVFDTIRRYFEYRGYKVNFIQNFTDIDDKMIKKANEENITVKELGDRFIHEYYKDADGLNIKRATANPRATEYMDEIIQFVKDLIDKGYAYEVNGDVYFSTKQFKEYGKLSGQNLDDLQAGARISVDERKKDPMDFAIWKSEKPGEPSWNCPWGKGRPGWHIECSCMAHKLLGDTIDIHAGGADLVFPHHENEIAQSEARNGKTFANYWMHSAYLNINNKKMSKSLNNFFTTREILEKYDAEVIRLFMLSAHYRTPLNFSDDLLQSAKASNERLYNAIGNLERLLDEVKVDKVTENEKEYVKNLESYKEKYIEKMDDDFNTADAISVIFDLVKDINTNINTESSKELVEYSLELIRELGKPLGILQKSTMLDLNAEIEKLIEQRQQARKDKDWALADKIRDDLKARGIVLEDTPQGVRWKREQ
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: USPA_ECOLI
Sequence: MAYKHILIAVDLSPESKVLVEKAVSMARPYNAKVSLIHVDVNYSDLYTGLIDVNLGDMQKRISEETHHALTELSTNAGYPITETLSGSGDLGQVLVDAIKKYDMDLVVCGHHQDFWSKLMSSARQLINTVHVDMLIVPLRDEEE
What is the function of this protein?
Required for resistance to DNA-damaging agents.
What are the official names of this protein?
Universal stress protein A.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPD2_STRCO
Sequence: MTGKPLVAILSGAGVSTDSGIPDYRGPNGLWRRDPEAEKLVTYEYYMGDPEIRRRSWLMRRDSAALHAEPNAAHRAVADLERRGVPVRVLTQNVDGLHQLAGVSARKVLELHGTARDCVCTGCGARGPMADVLARIEAGEDDPPCLDCGGVLKTATVMFGERLDPVVLGEAAAISKACQVFVAVGTSLQVEPAAGLARVAVEHGARLVVVNAEPTPYDELADEVIREPIGSALPALLRGLG
What is the function of this protein?
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
What are the official names of this protein?
NAD-dependent protein deacetylase 2, Regulatory protein SIR2 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class U subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTHS_BACFR
Sequence: MKSDIEIARSVELKKIKQVAESIGIPRDEVENYGRYIAKIPEYLIDEEKVKKSNLILVTAITATKAGIGKTTVSIGLALGLNKIGKKAIVALREPSLGPCFGMKGGAAGGGYAQVLPMEKINLHFTGDFHAITSAHNMISALLDNYLYQNQSKGFGLKEILWRRVLDVNDRSLRNIVVGLGPKTNGITQESGFDITPASEIMAILCLSKDVDDLRRRIENILLGYTYDNKPFTVKDLGVAGAITVLLKDAIHPNLVQTTEGTAAFVHGGPFANIAHGCNSILATKMAMTFGDYVITEAGFGADLGAEKFYNIKCRKSGLQPRLTVIVATAQGLKMHGGVSLDRIKEPNLEGLREGLRNLDKHVRNLHSFGQTVIVAFNKFASDTDEEMELLREHCEQLGVGYAINNAFSEGGEGAVDLANLVVETIENKPSEPLQFTYNDEDSVQQKIEKVATNLYGASVVTYSTLTRNKIKLIEEMGIGHYPVCIAKTQYSFSADPKVYGAVDNFELHIKDIVINNGAEMIVAIAGEIMRMPGLPKEPQALHIDIVDGNIEGLS
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: GRPE_CLOD6
Sequence: MDKKNEQQEVREENDTSINQESETQVELEEEVVNEECETSSEKTDEKEVDDENVTDINSKLAEKKLQDELDELNDKYQRLQAEYANYRRRTQQEKETIGVFANEKIITELIPVIDSMERALDACEDKEDTMYKGISLVHKQLIDTLVKFGVEEIEAESKEFDPNLHLAVMQESVDGVEANQIVMVLQKGYKLGTKVVRPSMVKVSC
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP51_CANGA
Sequence: MSTENTSLVVELLEYVKLGLSYFQALPLAQRVSIMVALPFVYTITWQLLYSLRKDRPPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNRDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFTSMVTLPTAPAKIYWEKRHPEQKY
What is the function of this protein?
Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (By similarity).  The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity).  In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity).  Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (By similarity).  Can also use susbtrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity).
What are the official names of this protein?
Lanosterol 14-alpha demethylase, CYPLI, Cytochrome P450 51, Cytochrome P450-14DM, Cytochrome P450-LIA1, Sterol 14-alpha demethylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane.
Protein: DPO3_STRP1
Sequence: MSDLFAKLMDQIEMPLDMRRSSAFSSADIIEVKVHSVSRLWEFHFAFAAVLPIATYRELHDRLIRTFEAADIKVTFDIQAAQVDYSDDLLQAYYQEAFEHAPCNSASFKSSFSKLKVTYEDDKLIIAAPGFVNNDHFRNNHLPNLVKQLEAFGFGILTIDMVSDQEMTEHLTKNFVSSRQALVKKAVQDNLEAQKSLEAMMPPVEEATPAPKFDYKERAAKRQAGFEKATITPMIEIETEENRIVFEGMVFDVERKTTRTGRHIINFKMTDYTSSFALQKWAKDDEELRKFDMIAKGAWLRVQGNIETNPFTKSLTMNVQQVKEIVRHERKDLMPEGQKRVELHAHTNMSTMDALPTVESLIDTAAKWGHKAIAITDHANVQSFPHGYHRARKAGIKAIFGLEANIVEDKVPISYEPVDMDLHEATYVVFDVETTGLSAMNNDLIQIAASKMFKGNIVEQFDEFIDPGHPLSAFTTELTGITDKHLQGAKPLVTVLKAFQDFCKDSILVAHNASFDVGFMNANYERHDLPKITQPVIDTLEFARNLYPEYKRHGLGPLTKRFQVSLDHHHMANYDAEATGRLLFIFLKDAREKHGIKNLLQLNTDLVAEDSYKKARIKHATIYVQNQVGLKNMFKLVSLSNIKYFEGVPRIPRTVLDAHREGLLLGTACSDGEVFDAVLTKGIDAAVDLARYYDFIEIMPPAIYQPLVVRELIKDQAGIEQVIRDLIEVGKRAKKPVLATGNVHYLEPEEEIYREIIVRSLGQGAMINRTIGRGEGAQPAPLPKAHFRTTNEMLDEFAFLGKDLAYQVVVQNTQDFADRIEEVEVVKGDLYTPYIDKAEETVAELTYQKAFEIYGNPLPDIIDLRIEKELTSILGNGFAVIYLASQMLVNRSNERGYLVGSRGSVGSSFVATMIGITEVNPMPPHYVCPSCQHSEFITDGSVGSGYDLPNKPCPKCGTPYQKDGQDIPFETFLGFDGDKVPDIDLNFSGDDQPSAHLDVRDIFGDEYAFRAGTVGTVAEKTAYGFVKGYERDYGKFYRDAEVDRLAAGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTASWQTTHFNFHDIDENVLKLDILGHDDPTMIRKLQDLSGIDPITIPADDPGVMALFSGTEVLGVTPEQIGTPTGMLGIPEFGTNFVRGMVNETHPTTFAELLQLSGLSHGTDVWLGNAQDLIKEGIATLKTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGYIDAMRENNVPDWYIESCGKIKYMFPKAHAAAYVLMALRVAYFKVHHPIMYYCAYFSIRAKAFELKTMSGGLDAVKARMEDITIKRKNNEATNVENDLFTTLEIVNEMLERGFKFGKLDLYKSDAIEFQIKGDTLIPPFIALEGLGENVAKQIVKARQEGEFLSKMELRKRGGASSTLVEKMDEMGILGNMPEDNQLSLFDDFF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBBY_CERSP
Sequence: MIEAILFDVDGTLAETEELHRRAFNETFAALGVDWFWDREEYRELLTTTGGKERIARFLRHQKGDPAPLPIADIHRAKTERFVALMAEGEIALRPGIADLIAEAKRAGIRLAVATTTSLPNVEALCRACFGHPAREIFDVIAAGDMVAEKKPSPDIYRLALRELDVPPERAVALEDSLNGLRAAKGAGLRCIVSPGFYTRHEEFAGADRLLDSFAELGGLAGLDLTAPVA
What is the function of this protein?
Highly selective xylulose-1,5-bisphosphate (XuBP) phosphatase.  Shows also activity towards ribulose-1,5-bisphosphate (RuBP) and fructose-1,6-bisphosphate (FBP), but not towards fructose-6-phosphate (F6P) or ribulose-5-phosphate (Ru5P) (PubMed:27246049).  Degrades xylulose-1,5-bisphosphate, a potent inhibitor of rubisco produced by the rubisco itself (PubMed:27246049).
What are the official names of this protein?
Protein CbbY, RuCbby.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: Y3873_PSEAB
Sequence: MSVDIRPTPPAQDSARQNVTLQIVSVVMFTFIGYLTIGIPLAVLPGYVHDDLGYGSVLAGLVISLQYLATLLARPYAGRVIDGLGPKRAVLYGMAGSAASGLFMLLSVAIQGWPALSLASLLVGRLVLGAAESLVGSAAIGWGIGRVGAPHTAKVISWNGIASYGAIALGAPLGVLLVQWLGLWSMGASIVLLGALGFALAWPKLPAPLVHGERLPFHHVLGRVTPHGMGLALGAIGFGTIATFITLYYASRGWANAVLCLSAFGGCFIGARLLFANSINRLGGFRVAIICLGVESLGLLLLWSAPNPWVGLAGAALTGFGFSLVFPAFGVEAVNLVPASNRGAALGAYSLFVDLSLGITGPLVGFVANLFGFRSMFLFACLASLSGLALAIALHRRSRRPG
What are the official names of this protein?
Uncharacterized MFS-type transporter PA14_38730.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YhhS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRUB_BORGP
Sequence: MENGFLLINKEQGKTSFETLFPIKKYFNTNHVGHAGTLDKFASGILIALVGKYTKLAGYFISLDKEYVAEFRFGLETDTLDSNGRIVNKADYIPSVEDIDLKLKDFVGEIYQSPPRFSSIHIDGIRAYKLALNGKFFEIKKRRVNVYDIQRLSYDFSSSSLSLKITCSKGTYIRSIARDLAYSLNSCAYVSNLKRTKIGMFRLKDSTLCKNLSKSSLISLESLSSFKKVYIDSSKVNLVKNGAYVEVQININEFKILKSREGEILAVIEGIGFNKYKYVIIF
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.