PharMolix/UniProtQA huggingface dataset:
Protein: PROB_PROM2
Sequence: MKTWVIKIGTSILRGTEETSTEEVIETLSRSFTSFLSKGNKIILVTSGAVGLGCQKLNIETRPNDLSTLQATAAVGQVNLMSLYDKVFNKLGHNIAQILITKADFNSRKSFNNASKTLKKLIDLNVIPIVNENDTVANEELKYGDNDTLSALVALAINANKLILLTDIENLYSKDPRNNNDAQPIKEVHNSELKEIKDKNIKNSNNEWGTGGIATKLISAEIATKGGVEVQLVDGTNKKNLIEIFNDNKIGTLFYPVEKPIRNKKSWLSHAIQTVGKITLDDGASFAIKRKGASLLAVGVKDVEGNFTINQAVKIVNTNDKEVAKGLVSISSDKLRSILNNKENNNSSIIVVHRDVLALS
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XGPT_AGRFC
Sequence: MSLPDKAFPVSWDQFHRDARALAWRLAGLDKEFRAIVCITRGGLVPAAIISRELNIRMIDTVCIATRHDYVNQGDTVLLKGVAPELTTDAGEGVLVVDDLTDTGKTALEVREMLPRAHFACVYAKPKGVPTIDTFVTEVSQDTWIYFPWDMGFTYQEPIAKGSRG
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SEP15_DANRE
Sequence: MAGEVYLLWLLPLLQGLASYGAELSSEACRELGFSSNLLCSSCELLGQFSLNQLDLPCRQCCQEEAQLENRKLYPGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI
What is the function of this protein?
May be involved in redox reactions associated with the formation of disulfide bonds.  May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).
What are the official names of this protein?
Selenoprotein F, 15 kDa selenoprotein.
What is the protein family that this protein belongs to?
Belongs to the selenoprotein M/F family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: AROQ1_PSEPK
Sequence: MATLLVLHGPNLNLLGTREPGHYGAVTLAQINQDLEQRARAAGHHLLYLQSNAEYELIDRIHAARNEGVDFILINPAAFTHTSVALRDALLAVSIPFIEVHLSNVHKREPFRHHSYFSDVAVGVICGLGASGYRLALESALEQLAANAQPK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase 1, 3-dehydroquinase 1, Type II DHQase 1.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: PALY_BROFI
Sequence: MEVSKENGLCLQGRDPLNWGAAAAELQGSHLDEVKKMVEEFRRPVVKLEGVKLKISQVAAVAFGGGASAVELAESARAGVKASSDWVLESVDKGTDSYGVTTGFGATSHRRTKQGGALQKELIKFLNAGIFGSGNSNTLPSAATRAAMLVRINTLLQGYSGIRFEILKAIATLLNKNITPCLPLRGTITASGDLVPLSYLAGILTGRPNSKARTPNGSTVDATTAFRLAGISSGFFDLQPKEGLALVNGTAVGSGVASIVLFETNILAVMAELLSALFCEVMQGKPEFTDHLTHKLKHHPGQIEAAAVMEHILEGSSYMKMAKKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRAATKSIEREINSVNDNPLIDVSRNKALHGGNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSSGRNPSLDYGFKGAEIAMASYCSELQALANPVTNHVQSAEQHNQDVNSLGLISSRKTAEAVDILKLMSTTFLVGLCQAVDLRHLEENLKNAVKNTVSQVAKRVLTMGVNGELHPSRFCEKDLIKVIDREYVFAYADDPCSSTYPLMQKLRAVIVEHALNNGVKEKDSNTSIFQKISSFENELKAALPKEVEAARAEFENGSPAIENRIKDCRSYPLYKFVKEVGSGFLTGEKVVSPGEEFDKVFNAICEGKAIDPMLDCLKEWNGAPLPIC
What is the function of this protein?
This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
What are the official names of this protein?
Phenylalanine ammonia-lyase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_DEIRA
Sequence: MNIMTANQGAVSPSQTESEASPPTFSHVPVLATEIVEALAPAPGKVFVDGTLGGAGHTRLLLGRGATVYGIDQDPYALDRARQAALPGLHVLQGNYRDMAELLPAAGVTQVDGILLDIGVSSFQLDDAGRGFSYHTEAPLDMRMSQSGESAADVVNDLDETELAALIYEYGEERHSRRIARFIVQAREKAPIETTVQLAEIIKRAYPGFSKGIHPARRTFQALRIYVNDELGALRDGLSAAEGLLAPGGRLAVISFHSLEDRIVKRFLLGSDVLTPLTKRPIVAAESEQVDNPRARSAKLRVGERAAAPEGS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RP34_BPSP1
Sequence: MSGRKKLTPPTHFDPEYLFKKYELLRKSVYKKFKDKMINQSDREDLMGTIDQIFLQLVSEYNPNRGVDFPYYIKRMLELRTYHHITKYLKRINGETSLYVKNEDGEVLELQDTIADMHAEEIFSRIVDLHSINPYMELGEKHRNLMIGLFIRKKTLQELAQEEGVPLDRLHARLYFLIRKFEKEHQIDTEIFGEDLY
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
What are the official names of this protein?
RNA polymerase sigma GP34 factor.
Protein: METK_STUS1
Sequence: MSEYSIFTSESVSEGHPDKIADQISDAVLDAIIAEDKHARVACETLVKTGVAIVAGEVTTSAWVDLEQLVRDVIVDIGYNSSEVGFDGATCGIINIIGKQSVDIAQGVDRTKPEDQGAGDQGLMFGYASNETDVLMPAPIRFSHALVERQAEARKNGLLPWLRPDAKSQVTCRYENGQVVGIDAVVLSTQHNPDVKQSDLREAVMELIIKHSLPAELLHKDTQYHINPTGQFVIGGPVGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLADRCEIQVSYAIGVAQPTSISLNTFGTGKLGDDKIIALVREHFDLRPYAITRMLDLLHPMYRATAAYGHFGRTPYEMTVGADTFTAFTWEKTDKADALRAAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
Protein: COBB_MYCTU
Sequence: MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA
What is the function of this protein?
Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.
What are the official names of this protein?
Hydrogenobyrinate a,c-diamide synthase, Hydrogenobyrinic acid a,c-diamide synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CbiA family.
Protein: RL27_GRABC
Sequence: MAHKKAGGSSRNGRDTEGRRLGVKKFGGESVVAGNIIVRQRGTKVQAGPNVGVGRDHTLFALTDGHVKFLRRAEGRVQVAVTPLAIAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: VM2I_CROVV
Sequence: AGEECDCGSPANPCCDAATCKLRPGAQCADGLCCDQCRFIKKGKICRRARGDNPDDRCTGQSADCPRNRFH
What is the function of this protein?
Inhibits fibrinogen interaction with platelets.  Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.
What are the official names of this protein?
Disintegrin viridin, Platelet aggregation activation inhibitor.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SDHD_PHOLL
Sequence: MKRTEIQQLLNEYPLVKNLMELEEIFWFNPCNTTLKEGLPFVGLGADDVEDAEARLDRFASYLCKAFPETAVTHGIIESEIVAIPTMQKTLEQHYGVGITGRILLKKDSHLPISGSIKARGGIYEVLTHAEKLALQAGLLAENDDYSKLFSEELRRFFNQYSIAVGSTGNLGLSIGIASAKLGFNVSVHMSADAREWKKQKLRSHGVNVVEHELDYGVAVARGRKEAESAPNCFFIDDENSQTLFLGYSVAGGRVKAQFEQMNIVVDEDHPLFVYLPCGVGGGPGGVAFGLKLAFGDHVHCIFAEPTHSPSMLLGVYTGLHDNICVQDIGIDNITAADGLAVGRASGFVGRAMERLLDGFYTVQDQEMYNLLGLLDRDEGIRLEPSALVGMAGPARVSGNLDYLNNKNLSAEKMKQATHLVWATGGGMVPDDEMTKYLATAKI
What are the official names of this protein?
D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: PGK_SULAC
Sequence: MIKVSDLVIPTINDLELQNKKVLLRIDVNSPVDKNTGKLLDDSRIKAHSITIKELLKKGNSIVLISHQGRPGDDDFISLKEHSLLLSKYVGTEIEFVEDIIGPYAVEKIKKLDNKGVIMLENIRLMSEELIEAPPQQHAKSFLIKKLSPLFDAYVNDSFSAAHRSQPSLVGFPLVLPSAAGIVMEKEVSALSKIFNYEDSPKIFVLGGGKVNDTLKIIENLIKNRVADRILTGGLVAELFAVAKGINLGKKNMQVLENKGLLSLVPRARKMLLSGAPIEIPVDFVTEQENSQTLEEPTSNLKGTIKDIGNTTIEMYSSFIKESKVVVLRGPMGVIEDERFRRGSKALLTSAVEGPGYVIIGGGHMISMIDKNIQINENKVHVSTGGGALLLFLAGEKLPVLESLHLSWVVRSGKS
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_SHIF8
Sequence: MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAIRGMINAVSFMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: HIS8_THEPX
Sequence: MIENLVREEIKGFKNYEVHSIPYRYKMDANETPFELPEEVIKNIQEIVKSSQVNVYPDPTAEKLKEELARYCGVVPTNIFVGNGSDEIIHLIMLAFINKGDVVAYPHPSFAMYSVYSKIAGAVEIPVRLREDYNYDVDSFIKVIEKYQPKLVFLCNPNNPTGSVIEREDIIKIIQKSNGIVVVDEAYFEFYGNTIVDAINEFENLIVLRTLSKAFGLAGLRVGYAVANENILKYLNLVKSPYNINSLSQIIALKVLRTDVLKERINYILEERKRLIKELGKIPGVKVYPSKTNFILVKFKDADYVYQGLLERGILVRDFSKVEGLEGALRITVSSCEANDYLINGLKELLL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: ACSA_HERAR
Sequence: MSSIESFKQEGRVFDSPVDFVNNAAISGMEAYRALCAEAADDYEGFWARLAQQNLHWTKPFTKKLDESNAPFYKWFEDGELNVSWNCLDRHLHNGNADKVAIIFEADDGNVTRITYKELHERVCKFANGLKSLSINKGDRVIIYMPMSIDGIAAMQACARIGATHSVVFGGFSAKSLHERIIDAGAVAVLTADYQVRGGKNLPLKAIVDEALAMGGCDTIRNVVVYKRTGGAVDFVERRDIWLHELVEQRTSECAPEPVGAEHPLFILYTSGSTGKPKGVQHSSAGYLLWAMLTMKWVFDIKPNDVYWCTADIGWVTGHTYVTYGPLAVGATQIVFEGVPMYPNAGRFWEMVQKHKVSIFYTAPTAIRSLIKAAEADPSTHPSKYDLSSLRLLGSVGEPINPEAWMWYYKNIGGERCPIVDTFWQTETGGHVISPLPGATPMVPGSCTLPLPGIIAAVVDDGGHDLPNGKGGLLVIKRPWPAMIRNIWNDPERFEKSYFPHELGGRTYLAGDGAIRNEETGYFTITGRIDDVLNISGHRMGTAEIESALVANPMVAEAAVVGKPDETTGESICAFVVLKRVRPEGDEAKQIAKELRDWVAKEIGPIAKPKEIRFGDNLPKTRSGKIMRRLLRVLAKDEDITQDISTLENPAILEQLKQAQ
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: NDUS3_PONPY
Sequence: MVAAVARLWWRGLLGASALTRGAGRPSVLLLPVRRESAGADTRPTVRPRNDVAHQQLSAFGEYVAEILPKYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPVYRQPPESLKLEAGDKKPDAK
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity).  Essential for the catalytic activity and assembly of complex I (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial, Complex I-30kD, CI-30kD, NADH-ubiquinone oxidoreductase 30 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RS17_LEGPL
Sequence: MSTNSESNARTMIGKVVSDKMDKTIVVMIERTVKHPKYGKIMKRRTKLHAHDENQVCRVGNTVKIRESRPLSKTKSWVLVEVIS
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: ARLY_ECOBW
Sequence: MALWGGRFTQAADQRFKQFNDSLRFDYRLAEQDIVGSVAWSKALVTVGVLTAEEQAQLEEALNVLLEDVRARPQQILESDAEDIHSWVEGKLIDKVGQLGKKLHTGRSRNDQVATDLKLWCKDTVSELLTANRQLQSALVETAQNNQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLARDESRLQDALKRLDVSPLGCGALAGTAYEIDREQLAGWLGFASATRNSLDSVSDRDHVLELLSAAAIGMVHLSRFAEDLIFFNTGEAGFVELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCQEAAQQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGKPLEDLPLSELQKFSQVIDEDVYPILSLQSCLDKRAAKGGVSPQQVAQAIAFAQARLG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BHMT1_XENLA
Sequence: MAPVGAKKGLLERLDAGEVVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGANVMQTFTFYASDDKLENRGNYVAEKISGQKVNEVACDIAREVANEGDALVAGGVSQTPSYLSCKSEVEVKGIFRKQLDVFIKKNVDFLIAEYFEHVEEAVWAVEVLKESGKPVAATLCIGPEGDLNGVSPGECAVRLAKAGASVVGVNCHFDPMTCVATVKLMKEGLVAAKVKAHLMTQPLAYHTPDCGKQGFIDLPEFPFALEPRIVTRWDIHKYARAAYDLGVRYIGGCCGFEPYHTRAIAEELAPERGFLPKGSEKHGSWGSGLEMHTKPWVRARARRDYWEKLPPASGRPYCPSMSKPDEWGVTKGDADLMQQKEATTEQQLKDLIAKQGIKSN
What is the function of this protein?
Involved in the regulation of homocysteine metabolism.  Converts betaine and homocysteine to dimethylglycine and methionine, respectively.  This reaction is also required for the irreversible oxidation of choline (By similarity).
What are the official names of this protein?
Betaine--homocysteine S-methyltransferase 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAND_SYNAS
Sequence: MQRLMLKSKIHRATVTDADLHYEGSISIDEALMEAADLLPYEKVAIYDVNNGERFTTYVITGKRGSGVICLNGAAARKVAKGDLVIIASYVIVDGEEAKGWKPTCVFVDPENQIKH
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_THEP3
Sequence: MSKIEQIAKDLVMPVLEKNNFELVDVEYKKEGSHWYLRVYIDKEGGITLDDCQLVSEYLSDRLDEVDPIEHSYILEVSSPGLDRPLKKPRDFERNIGKEIEISLYAPIDKRKKFEGELIEFTGDKIIILYNGERKEFDMKNVSLVKPVIKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_LACJO
Sequence: MTYFLGLTGGIASGKSTADEFFKKKKIPIIDSDLIAHQIMEIGQNGYKAVVDYFGTDILNDDQTINRRKLGGIVFNDKAKLKKLNELTHPLVHQEIKQQMARYRANQEKLVVIDVPLLFESGFESLCNGVLAISITPELQIERLMKRNAFTKKEAVARISNQMPLSEKEKRATYVVANTGTIGDLEKKLSDLLQEIGR
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_VESOH
Sequence: MNQEKVLKTLLMPIVSEKMTMLSANNQYAFKVRMDSSKREIKAAVEILLGVNVENVTTLIVKGKKKIFKGRTGSRPNWKKAMVKVSAGQIIDVNRT
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: TRUA_METLZ
Sequence: MKLAFLAGYRGQNFAGSQYQPHKRTVEGEFVAGGIELGLFSDAKEAHFRTAGRTDKGVSARRQLFSITTEKPELAIEALNFHLPDDIWCIGAAEVDEEFYPRYAARERSYRYYFPYPADVSRMQDAASRLIGTHNFSGFAKMEAGRDPVRTVTRAEVFEGKDGCPVFEVAAKSFLWNMVRGMAGALQTIGLGLCEPDVIEELLSSPTARVHPAPAEGLVFWDVVCDLSFTPMRQKREVKRSLAKEAAAARADMHTAEALLEDDPEEFWKKKVIRGYSALMK
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: ARHG1_HUMAN
Sequence: MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT
What is the function of this protein?
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916).  Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:9641915, PubMed:9641916, PubMed:8810315, PubMed:30521495).  Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916).  This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916).  Mediates angiotensin-2-induced RhoA activation (PubMed:20098430).
What are the official names of this protein?
Rho guanine nucleotide exchange factor 1, 115 kDa guanine nucleotide exchange factor, p115-RhoGEF, p115RhoGEF, Sub1.5.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
Protein: RL4_SHEB2
Sequence: MELVLKDAQSALEVSETTFGRDFNEALVHQVVVAYAANARQGTRAQKTRAEVTGSGKKPWRQKGTGRARAGSVKGPIWRGGGVTFAAKTQDHSQKVNKKMYRGALKSILSELVRQERLVVVESFGVEAPKTKELKAKLKAMNLEDVLIVTAEVDENLFLAARNLYKVDVRDVAGLDPVSLIAFNTVLVTADAVKQIEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: CHEB2_RHOPB
Sequence: MIRLLIADDSALVRKLLEGVFLEEGDFEIRTARTGLEALDMVRAFDPHVVTLDVQMPGMDGLTCLGRIMLEAPRPVVMISSLTEQNADATLSAMALGAVDVIAKPGGTFSLELDRLRPLLVATIRSAAQAKIRPTHRLADRIRHQFRDAASSPRAKAARRGAARQRAKAEPAPGLVLIGTSTGGPAALNILLPQLPADFPWPVLIAQHLPATFTGAFAKRLDRECALNVVEVDVPRQLEPGTVYIGRGDADVIVAPRPSGLIALSVPARRDYPWHPSVERMVDSALEHYDGKRLLGVLMTGMGDDGATAMTRLQALGGRTIAEAESTAVVWGMPGELVRQGGATLVLPVEEIAAAVIEWGNADAAD
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 2.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYPD1_MOUSE
Sequence: MWVLGIAATFCGLFWLPGLALQIQCYQCEEFQLNNDCSSPEFIVNCTVNVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCCNTPLCNGPRPKKRGSSASAIRPGLLTTLLFFHLALCLAHC
What is the function of this protein?
Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.  In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs (PubMed:19246390).  May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface (PubMed:26276394, PubMed:25716842).  May be involved in the control of anxiety (PubMed:19246390).
What are the official names of this protein?
Ly6/PLAUR domain-containing protein 1, Ly-6/neurotoxin-like protein 2, Lynx2.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: FOLD_BREBN
Sequence: MAATILQGKEVAQSIRAELANEVVELKKQGVVPGLTVVIVGDDPASHSYVRGKAKGCEEVGISSEIIRKDADITEEELLVIIQQLNENPNVNGILVQLPLPAHISEHAVIEAIAPEKDVDGFHPISIGNMVLGNDTMLPCTPHGIIELIKRTGTQMAGKHAVVIGRSNIVGKPVSLLLQQENATVTMCHSRTQNLEEYTQKADILVVATGRAHMIGKEHVKPGAVVIDVGVNRIETGKLVGDVKFDEVKDVASFITPVPGGVGPMTITMLLKNTVAAAKKQAKQ
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: LRC25_BOVIN
Sequence: MGGPLMWALLLPLLLHQAGSQTSSCSVLSGYMDWTKEYFDTCLNFSGKILTQLPQNQSLRARSVQLLDLSANGLQRLPWSFFRDLEQLQLLIVTNNSLDFVDRALXXXGCGLELLADCSCALLDWHTDRQDNCSGPELPRCLDVPTGAWHNLSVFLDVSCPSGLTKIAIGALAASGSLLLVLAIAGPVLAWRFCRHRMDQNLSKTWASQDGSRSGSGRQPRYSSQGRRPKSPANTPPRSSTPDYENVFVGPPAARHQWDELRSPPSEGGDFYMTYDSLQHESQPVYCNLQSLSQVPLDDEEYVVPGR
What is the function of this protein?
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation.  Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy.  Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
What are the official names of this protein?
Leucine-rich repeat-containing protein 25, Monocyte and plasmacytoid-activated protein.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cytoplasm.