PharMolix/UniProtQA huggingface dataset:
Protein: ISPE_HYPNA
Sequence: MSTADKSLSGWAPAKVNLYLHVGPPKPNGRHDLESLVMFSGSGAADHLTAEPAEGLSLSVAGPFAAAAGAGDDNLVLQAARALQAASGTQQGARLSLKKWLPVAAGIGGGSSDAATALRLLTKLWALDPNHAIALAPGLGGDVPVALAGQPSLMRGEGERVTPLPALPPVYAVLVNPGVPCPTGPVFRDHDAAGGGAGFAEIDPPPEFSGPKAFAAWLGQQRNDLESPAIARVPEIGAVLEFLRAQPGVLLARMSGSGATCFALCEALAFAERATAVIAHDAHKAHWWTAASRLGAAP
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: CHDC_STAS1
Sequence: MPQAPETLDGWYSLHLLYAIDWSSLRLVPTEERQTIVDELQTFLNKHEEARTNHVGDHAFYNITGQKADILLWALRPEMKDLNAFENEFNKLKIADFLIPTYSYVSIIELGNYLAGKSDEDPYENPHIKPRLFPELPQSEYICFYPMDKRRNETYNWYMLPLEKRQELMYAHGKIGRQYAGKIKQFITGSVGFDDFEWGVTLFADDPLQFKKIVYEMRFDETTARYGDFGSFYVGHIVTKDNLQDLFAL
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: RECX_BACC2
Sequence: MAVITKIEVQKRSKERFNIYIDKGQGEEYGFSVDQVILMKHGLQKGLEIDEIELGNILYNEEVQKAYLQAISYLSYQMRTKQEIEDFLRKKEVGQAIISEVVSKLLHDRYINDKEYAVLYTRTQSNVNRKGPTVIKRELLNKGVQDLIIMHSLQEYPKEKQIENALFLIEKKKKSYQKHSFLQMKLKLDEMLVRKGYSREVIQICLEELKDERDDEKQQEALHYHGNKYYEKYKKYDGWTFENKMKQALYRKGFSIDEIEIFLQMKREEG
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2C51_ARATH
Sequence: MTSSIKSSLLNLGLLIIFFVFFFLVINCRGESSTCLAVYKQGGAPAVFQSPKCPRWILQNWGSPTHSGAGRCHTAAIQGRRNYQEDRLLCALDLRIPFPGKTGTPKDVLVGIAAVFDGHNGAEASDMASKLLLDYFALHINFLLDATFSAMTRKLIGRFPTKGDHSVILHGVSRDEIMHLYNLDFQMQFRDSLPLHFDDSLPLDIMKEALLRAIHDIDVTFTKEASNRKLNSGSTATIALIADGQLMVASIGDSKALLCSEKFETLEEARATLVKLYRERRRNRGSSPSRFSDFKLEHGNGLLRFIAKELTKDHHPNREDEKIRVEAAGGYVTEWAGVPRVNGQLTVSRAIGDLTYRSYGVISAPEVMDWQPLVANDSFLVVSSDGIFEKLEVQEVCDLLWEVNNQTSSGAGVPSYCSISLADCLVNTAFEKGSMDNMAAVVVPLKSNLVTQLQRKEQSMNDNKDKIASALPCSNCTLPLPNDINLGPLQLKQAQPLGTMFNRLLRLKTEVFAAFICQRTLLGHLKGK
What are the official names of this protein?
Probable protein phosphatase 2C 51, AtPP2C51.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CH602_ACIC1
Sequence: MPKLLYYAEDARGALQRGVDHLADTVKVTLGPKGRNVVLATSGNKVTITNDGVTIAREIELDERDENLGAQLVKEVATKTNDVAGDGTTTATVLAQAMVREGLRNVAAGANPLALKRGIDAAVTAISDRLLAQAREVATKDEIANVATISAQDPAVGAVIADAFDKVGKDGVITVEESNTMGLELEFVEGLQFDKGYISPYFITDPERMEAVLDNPYILLHEGKISNAMDFVPLLEKVVQAGRPLLVIAEDVEGDALATLVVNKIRGTFSSVAVKAPGFGDRRKAMLGDMAVLTGAQVVSPEVGLKLDEVGLEVLGTARRVRVTRDDTTIVEGGGSAEAIQDRIRQIRAQIDQTDSDWDREKLQERLAKLAGGVAVIRVGAATEVELKEKKHRLEDAVSATRAAIEEGIVAGGGSALLHASSALDSLELTGDEAVGASIVRKAAAEPLRWIAENAGFEGYVVCSRVRDLPVGHGFDAQTGEYTDLVARGIIDPVKVTRSALTNAASVVGLLLTTEAIVVDKPEEKPESAGHNHGHGHHHPH
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16A2_LEPCP
Sequence: MPLSNRSTLTQYLIEERRRFPGASGELNALILDVSLACKAIARAVAFGELGDALGDAAAMPTGGAVNVQGEVQKKLDVLSNEVFIRRNEWSGSLAGMASEEMETPYQIPGQYPRGKYLLVFDPLDGSSNIDVNVSVGSIFSILRAPQDVIDSGRDVTEADFLQPGAAQVAAGYALYGPTTMLMLTVGNGVAGFTLNPTLGEFMLTHANVTVPADTREFAINASNARFWEPPVKRYVDECLAGATGPRGKDFNMRWIASMVAEAHRILMRGGVFMYPRDTKDASKPGRLRLLYEANPIGMLMEQAGGRASTGRQPMLGVKPTSLHQRIGLVFGSKNEVERIERYHHEPVTREFATPLFAERSLFRD
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1 2, FBPase class 1 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 2.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIE1_MOUSE
Sequence: MVWWGSSLLLPTLFLASHVGASVDLTLLANLRITDPQRFFLTCVSGEAGAGRSSDPPLLLEKDDRIVRTFPPGQPLYLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSAHVHKEKQTDVIWKNNGSYFNTLDWQEADDGRFQLQLQNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILSMATEVEFNIGTMPRINCAAAGNPFPVRGSMKLRKPDGTMLLSTKVIVEPDRTTAEFEVPSLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPPVPLTAPRLLAKQSRQLVVSPLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPSENVTLMNLKPKTGYNVRVQLSRPGEGGEGGWGPSALMTTDCPEPLLQPWLESWHVEGPDRLRVSWSLPSVPLSGDGFLLRLWDGARGQERRENISFPQARTALLTGLTPGTHYQLDVRLYHCTLLGPASPPAHVHLPPSGPPAPRHLHAQALSDSEIQLMWQHPEAPSGPISKYIVEIQVAGGSGDPQWMDVDRPEETSIIVRGLNASTRYLFRVRASVQGLGDWSNTVEEATLGNGLQSEGPVRESRAAEEGLDQQLVLAVVGSVSATCLTILAALLALVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
What is the function of this protein?
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
What are the official names of this protein?
Tyrosine-protein kinase receptor Tie-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: SYE_RHOPS
Sequence: MTRPVVTRFAPSPTGFLHIGGGRTALFNWLYARKHGGKMLLRIEDTDRQRSTQPAIDAILDGLKWLGIEWDGDTVYQFARAARHREVAEQLLAEGKAYRCYATAEELTAMRDKARAEGRSKLYDGSWRDRDPSDAPADLNPTIRLRAPLTGETVIEDQVQGRVVWQNENLDDLVLLRGDGTPTYMLAVVVDDHDMDVTHIIRGDDHLINAARQKQIYDAMGWELPVMAHIPLIHGPDGSKLSKRHGALGVDAYRAMGYLPAALRNYLVRLGWSHGDQELFTTQEMIDAFDLSAIGRSAARFDFAKLESLNGHYIRQTDDQSLVTLLEDLLHYVPQGPAIAARLTDTTRAQLLQAMPGLKERAKTLLELLDNAGFIFADRPLAVDTKGQTVLTPETRALIGRLRAALEDVSPWTAANTEAAMRTFAEQTGLKLGAVAQPLRVALTGRTTSPGIFDVLAVLGREECLSRLADQAA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_MACCJ
Sequence: MSLRYESIESLSQMIQNKTIRPSELIEDTFVNIEKDDTVINSFLALDKEAALEKAKTMDNETPSGKLFGIPMGIKDNIVTKDVETTCASKILEGFNSVYDATVMNKLNAENGILVGKLNMDEFAMGGSTENSFYKKTVNPFDHKAVPGGSSGGSAAAVAASLVPFSLGSDTGGSIRQPASYCGVVGMKPTYGRVSRFGLVAFASSLDQIGPITRNVKDNATVLEVISGLDPHDSTSAPVDNVDFTSQIDKDIKGLRVAVPKEYLGEGVSEEVKASVQAAIKALEKMGATVEEVSLPNSKYGVATYYILSSSEASANLARFDGIRYGYQAEGAQNLEELYKKTRQEGFGDEVKRRIMLGTYALSSGYYDAYYKKAQKVRTLIKQDFERVFENYDIIVGPTAPTTAFDIGAQINDPLTMYANDILTIPINLAGLPSMSIPCGESNGRPIGLQLIGKPFDEKTLYNVAYNYEQIFNMHERYQSL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: NCAP_PIARV
Sequence: MSDNIPSFRWVQSLRRGLSNWTHPVKADVLSDTRALLSALDFHKVAQVQRMVRKDKRTDSDLTKLRDMNKEVDALMNMRSVQRDNVLKVGGLAKEELMELASDLDKLRKKVTRTEGLSQPGVYEGNLTNTQLEQRAEILRSMGFANARPAGNRDGVVKVWDIKDNTLLINQFGSMPALTIACMTEQGGEQLNDVVQALSALGLLYTVKFPNMTDLEKLTQQHSALKIISHEPSALNISGYNLSLSAAVKAAACMIDGGNMLETIQVKPSMFSTLIKSLLQIKNREGMFVSTTPGQRNPYENLLYKICLSGDGWPYIGSRSQVQGRAWDNTTVDLDSKPSAIQPPVRNGGSPDLKQIPKEKEDTVVSSIQMLDPRATTWIDIEGTPNDPVEMAIYQPDTGNYIHCYRFPHDEKSFKEQSKYSHGLLLKDLADAQPGLISSIIRHLPQNMVFTAQGSDDIIRLFEMHGRRDLKVLDVKLSAEQARTFEDEIWERYNQLCTKHKGLVIKKKKKGAVQTTANPHCALLDTIMFDATVTGWVRDQKPMRCLPIDTLYRNNTDLINL
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  The encapsidated genomic RNA is termed the nucleocapsid (NC).  Serves as template for viral transcription and replication.  The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses.  Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation.  Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: CRK6_ARATH
Sequence: MSSLISFNFLFLFSFLTSSFTASAQDPFYLNHYCPNTTTYSSNSTYSTNLRTLLSSLSSRNASYSTGFQNATAGKAPDRVTGLFLCRGDVSPEVCRNCVAFSVNQTLNLCPKVREAVFYYEQCILRYSHKNILSTAITNEGEFILSNTNTISPNQKQIDGFTSFVSSTMSEAAGKAANSSRKLYTVNTELTAYQNLYGLLQCTPDLTRADCLSCLQSSINGMALSRIGARLYWPSCTARYELYPFYNESAIETPPLPPPPPPPPPRESLVSTPPISSSSLPGKSGNSTVLVVAVVVLAVLLFIALVGYCFLAKKKKKTFDTASASEVGDDMATADSLQLDYRTIQTATNDFAESNKIGRGGFGEVYKGTFSNGKEVAVKRLSKNSRQGEAEFKTEVVVVAKLQHRNLVRLLGFSLQGEERILVYEYMPNKSLDCLLFDPTKQIQLDWMQRYNIIGGIARGILYLHQDSRLTIIHRDLKASNILLDADINPKIADFGMARIFGLDQTQDNTSRIVGTYGYMAPEYAMHGQFSMKSDVYSFGVLVLEIISGRKNSSFGESDGAQDLLTHAWRLWTNKKALDLVDPLIAENCQNSEVVRCIHIGLLCVQEDPAKRPAISTVFMMLTSNTVTLPVPRQPGFFIQCRAVKDPLDSDQSTTTKSFPASIDDESITDLYPR
What are the official names of this protein?
Cysteine-rich receptor-like protein kinase 6, Cysteine-rich RLK6, Receptor-like protein kinase 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL28_BACAC
Sequence: MARVCTITGRKARSGNSRSHAMNATKRKWGANLQKVRVRIDGKVQRVYVSARALKSGKIERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: ZUPT_SALNS
Sequence: MSVPLILTLLAGAATFIGAFLGVLGQKPSNRVLAFSLGFAAGIMLLISLMEMLPAALDTEGMSPVLGYGMFIIGLLGYFGLDRLLPHAHPQDLVQKRQQPLPGSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAIFWAGISGMAEILGGVLAWLILGSLVSPIVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSIMGLSLVILQTIGIG
What is the function of this protein?
Mediates zinc uptake.  May also transport other divalent cations.
What are the official names of this protein?
Zinc transporter ZupT.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACTT1_RAT
Sequence: MLNTARLDNPAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKLWKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPIYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWGSKDSEKCYQRSLSEYKLPDGNTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGTPIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKCF
What is the function of this protein?
Negatively regulates the Hedgehog (SHH) signaling.  Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.
What are the official names of this protein?
Actin-related protein T1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Nucleus. Note=Both detected in the nucleus and cytoplasm, localizes to the nucleus where it binds chromatin upon stimulation of the Hedgehog pathway.
Protein: MIMG_MYCS2
Sequence: MAKELRFNSDARARLEQGVNALADAVKVTLGPKGRNAILEKLTGPPTITNDGVTIAREIQLRDPFANMGAQLVKEVAMKTNGVVGDGTTTATVLAQAMVREGLAAVEAGANPMRVRRGIERTVPVVVESLRSHSVEVGSSSDLRRIAALAASDDEAIGDVIAAAVEHVGKTGVVTTEESDTLGMAVDVVDGIEFDHGYTSGYMVTDPERMEAVLDNPLILLTNKKISQVQEIMPTLEVAKRADRPLVVIAEDVDGPALQLLVGGNMHKTMQSVVVRAPGFGHRRVAELEDLAVALGGHVIAKDTGIDLGEVAREHLGSCDRLTATESDTTIVGPRGHQNLVDARVAQLEVQRERARIDADRDILDLRIARLTGRVAVIRVGGATSVELKERMLRVEDALAATRAALEAGIVSGGGTALAQAHRVLDAVELVGDEAIGRDVVRRALSEPLRWIAFNAGFEGGDVVDVVADLPLGHGFNALTGEYGDMFEEGIIDPFKVTRAALESAASIAALLITTETAVVEEILGQPGAIMAPGFGDLAEGMVRPSNIY
What is the function of this protein?
Plays an essential role in the productive folding of MimA and MimC, and thus in the formation of the active MimABCD complex.
What are the official names of this protein?
Chaperonin-like protein MimG.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_STRPD
Sequence: MRCPKCNYHKSSVVDSRQAEDGNTIRRRRECEQCHTRFTTFERVEELPLLVIKKDGTREQFSRDKILNGVVQSAQKRPVSSTDIENVISRIEQEVRTTYENEVSSTAIGNLVMDELAELDEITYVRFASVYKSFKDVDEIEELLQQITNRVRGKKKRLNNDETN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PSBQ_PEA
Sequence: EAIPIKVGGPPPLSXGLPGTLNSDEARDLKLP
What are the official names of this protein?
Oxygen-evolving enhancer protein 3, OEE3, 16 kDa subunit of oxygen-evolving system of photosystem II.
What is the protein family that this protein belongs to?
Belongs to the psbQ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Protein: ICS3_YEAST
Sequence: MHISLPTRNKSYFRIRTRTYQIGLYHSDSSPIRDISVLHLLIATLCTIFFPIFFSLSKVQVVQWQGTTISKNCIALTMSFPLNAIPGMYLIIAFPRLQTVIPLQRNTPVRITKSVIVKGAVSVPRISSPMH
What are the official names of this protein?
Increased copper sensitivity protein 3.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YO007_HUMAN
Sequence: MAETYRRSRQHEQLPGQRHMDLLTGYSKLIQSRLKLLLHLGSQPPVGKTFFFSCWCHPLFHGSKTTPNVWYKFSETALSILNSCQASQLGVRKMPGDMSSSPRVREFSALVAIKEKIHILPTNAKVGSKFGS
What are the official names of this protein?
Putative uncharacterized protein DKFZp434L187.
Protein: PURA_AJECH
Sequence: MVTIVLGAQFGDEGKGKITDLLSQSATLCCRAAGGHNAGHTIVHDNITYDFHILPSGLIAPDCVNLIGTGTVVHLPSFFKELDALKAKGLKDAHERIFISDRAQVCFDLHSVVDGLEEASLAGKKVGTTGKGIGPCYSDKAARRGVRIGEVLEEGVVEDNLRKLEAGYRARFGELNYDLEEEIGRFNEYRTKLQPYVVDQMTFLAKYRSSPSILVEGANALMLDIDHGTYPYVTSSCTGVGGAIQGLTLNPTSIRSIIGVVKAYSTRVGSGPFPTEQNNAIGEKMQTIGREFGVTTGRRRRCGWLDMVMCRYSNSINHYTSINLTKLDILDDFDEIKVAVAYKLDGKRLESFPALPGVLDKVEAEYVTFPGWKSTTMGITRWEDLPANAQRYIQFIEREMGGVPIKWIGTGPARTHMIEREV
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_CLOBB
Sequence: MSVISMKQLLEAGVHFGHQTRRWNPKMAPYIFTERNGIYIIDLQKTVRKAEEAYNFIKEVSTEGKDILFVGTKKQAQDAIKDEAIRSSMHFVNNRWLGGMLTNFSTIKKRIRRLSEIETMQEDGTFEVLPKKEVIKLKGELEKLEKNLGGIKNLDCDNIGAMFVVDPRKEKNAISEAKILGIPVVAIVDTNCDPEEVDYVIPGNDDAIRAVKLITAKMADAIMEGRQGEELAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: CCU43_ARATH
Sequence: MADQIEIQRMNQDLQEPLAEIMPSVLTAMSYLLQRVSETNDNLSQKQKPSSFTGVTKPSISIRSYLERIFEYANCSYSCYIVAYIYLDRFVKKQPFLPINSFNVHRLIITSVLVSAKFMDDLSYNNEYYAKVGGISREEMNMLELDFLFGIGFELNVTVSTFNNYCCFLQREMAMLMKMKSLFLEPSSFKISSKTKLVMYPHEEDSLSTHHNKKQLAAA
What are the official names of this protein?
Cyclin-U4-3, CycU4;3, Cyclin-P4.2, CycP4;2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin U/P subfamily.
Protein: PEG10_MOUSE
Sequence: MAAAGGSSNCPPPPPPPPPNNNNNNNTPKSPGVPDAEDDDERRHDELPEDINNFDEDMNRQFENMNLLDQVELLAQSYSLLDHLDDFDDDDEDDDFDPEPDQDELPEYSDDDDLELQGAAAAPIPNFFSDDDCLEDLPEKFDGNPDMLGPFMYQCQLFMEKSTRDFSVDRIRVCFVTSMLIGRAARWATAKLQRCTYLMHNYTAFMMELKHVFEDPQRREAAKRKIRRLRQGPGPVVDYSNAFQMIAQDLDWTEPALMDQFQEGLNPDIRAELSRQEAPKTLAALITACIHIERRLARDAAAKPDPSPRALVMPPNSQTDPTEPVGGARMRLSKEEKERRRKMNLCLYCGNGGHFADTCPAKASKNSPPGKLPGPAVGGPSATGPERIRSPPSEASTQHLQVMLQIHMPGRPTLFVRAMIDSGASGNFIDQDFVIQNAIPLRIKDWPVMVEAIDGHPIASGPIILETHHLIVDLGDHREILSFDVTQSPFFPIVLGIRWLSTHDPHITWSTRSIVFNSDYCRLRCRMFAQIPSNLLFTVPQPNLHPYLLHHVHPHVHPHMHQHLHQHLHQFLHPDPHQYPHPDPHYHHHQQADMQHQLQQYLYQYLYYHLYPVMHHHLPPDQHEHLHEYLHQYLHQYLHQFLHHHLHPDLHQYLYQYLHNHMNPDPHHHPHPDPPQDPHHPPHQDPHQHPDPHQDPPHQDPHQDAHQDPHMDPHLHQHQHPQPQPHPQQHPNHPQQPPFFYHMAGFRIYHPVRYYYIQNVYTPVDEHVYPGHRVVDPNIEMIPGAHSLPSGHLYSMSESEMNALRNFVDRNVKDGLMTPTVAPNGAQVLQVKRGWKLQVTYNCRAPQSGTIQNQYLRMSLPNMGDPAHLASYGEFVQVPGYPYPAYVYYTSPHMMTAWYPVGRDVHGRIIVVPVVITWSQNTNRQPPVPQYPPPQPPPPPPPPPPPPPPPPASSCSAA
What is the function of this protein?
Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:30951545, PubMed:34413232).  Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232).  Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232).  Involved in placenta formation: required for trophoblast stem cells differentiation (PubMed:16341224, PubMed:30951545).  Involved at the immediate early stage of adipocyte differentiation (PubMed:17707377).  Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (By similarity).  Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (By similarity).  May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (PubMed:9473521).
What are the official names of this protein?
Retrotransposon-derived protein PEG10, MmPEG10, Embryonal carcinoma differentiation regulated protein, Mammalian retrotransposon-derived protein 2, Myelin expression factor 3, MyEF-3, Myelin expression factor 3-like protein 1, MEF3-like protein 1, Paternally expressed gene 10 protein, Retrotransposon gag domain-containing protein 3, Retrotransposon-derived gag-like polyprotein, Ty3/Gypsy-like protein.
What are the subcellular locations of this protein?
Extracellular vesicle membrane. Cytoplasm. Nucleus. Note=Forms virion-like extracellular vesicles that are released from cells.
Protein: CREN7_PYRCJ
Sequence: MDQDVAEEILNKEYEVVYEGKRFLLKPAKAWVLQPPGKPGVIVALFKLPNGKTVRKVIARLPP
What is the function of this protein?
A probable chromatin protein, binds double-strand DNA without sequence specificity.  Constrains negative DNA supercoils.
What are the official names of this protein?
Chromatin protein Cren7.
What is the protein family that this protein belongs to?
Belongs to the Cren7 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_THEFI
Sequence: MKRTWQPNRRKRAKTHGFRARMKTKSGRKVLKRRRQKGRHRLTV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RS17_PSEF5
Sequence: MAEAEKTVRTLTGRVVSDKMDKTITVLIERRVKHPIYGKYVKRSTKLHAHDETNQCHIGDKVTIRETRPMAKTKSWALVDVLERAVEV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RL30_STRPZ
Sequence: MAQIKITLTKSPIGRKPEQRKTVVALGLGKLNSSVVKEDNAAIRGMVTAISHLVTVEDVK
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: SOX7_XENLA
Sequence: MTTLMGSYSWTESLDCSPMDGDLSDGLSPHRSPREKGSETRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALSPAQKRPYVEEAERLRVQHMQDYPNYKYRPRRKKQIKRICKRVDTGFLLGSLSKDQNSVPDTRGCRTAMEKEENGGYPGAALSDIRHYRETPSNGNKYDQTYPYGLPTPPEMSPLEAIDQDQSFYSTSCSEDCHSHINGAVYPPEYSRSPILCSHLSQVPIPQPGSSMIPPVPTCPPAYYSSSYHSIHNYHAHLGQLSPPPEHPHYDTIDQISQAELLGEMDRNEFDQYLNTSLQDPTEMTIHGHVQVSQASDIQPSETSLISVLADATATYYNSYSVS
What is the function of this protein?
Transcription factor.  Binds to the DNA sequence 5'-AACAAT-3'.  Acts downstream of vegt and upstream of nodal signaling to promote endodermal and mesodermal differentiation by promoting vegt-induced expression of both endodermal genes (including endodermin) and mesodermal genes (including snai1/snail and snai2/slug).  Induces expression of multiple nodal genes (including nodal, nodal2, nodal4, nodal5 and nodal6) and binds directly to sites within the promoter of the nodal5 gene.  The endodermal and mesodermal specification pathways then interact to initiate cardiogenesis.  Acts partially redundantly with sox18 during cardiogenesis.  Also acts as an antagonist of beta-catenin signaling.  Regulates (possibly indirectly) development of the pronephros, the functional larval kidney.
What are the official names of this protein?
Transcription factor Sox-7, xSOX7.
What are the subcellular locations of this protein?
Nucleus.
Protein: PILR1_LINUS
Sequence: MGRCRVLVVGGTGYIGKRIVKASIEHGHDTYVLKRPETGLDIEKFQLLLSFKKQGAHLVEASFSDHESLVRAVKLVDVVICTVSGAHSRSLLLQLKLVEAIKEAGNVKRFIPSEFGMDPARMGDALEPGRETFDLKMVVRKAIEDANIPHTYISANCFGGYFVGNLSQLGPLTPPSDKVTIYGDGNVKVVYMDEDDVATYTIMTIEDDRTLNKTMYLRPPENVITHRQLVETWEKLSGNQLQKTELSSQDFLALMEGKDVAEQVVIGHLYHIYYEGCLTNFDIDAAQDQVEASSLYPEVEYIRMKDYLMIYL
What is the function of this protein?
Reductase involved in lignan biosynthesis.  Catalyzes the enantioselective conversion of (-)-pinoresinol into (-)-lariciresinol and of (-)-lariciresinol into (+)-secoisolariciresinol.  Abstracts the 4R-hydride from the NADPH cofactor during catalysis.
What are the official names of this protein?
Bifunctional pinoresinol-lariciresinol reductase 1, PLR-Lu1, (-)-lariciresinol reductase, (-)-pinoresinol reductase.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.