PharMolix/UniProtQA huggingface dataset:
Protein: DNAJ_XANCP
Sequence: MSKRDYYEVLGVARGASDEELKKAYRRCAMKYHPDRNPGDAAAEATFKECKEAYEVLSDGNKRRAYDAHGHAAFEHGMGGGGGGPGGPDMGDIFGDIFGNIFGGGAAGPRAARRGADVGYVLELDLEEAVAGIERRIEIPTLIECEPCHGSGSEDGKVEVCATCHGRGQVRIQRGIFAMQQSCPHCDGRGTLIQNPCKTCHGAGRVEEDKVLSIKVPAGVDTGDRIRLAGEGEAGPAGTPPGDLYVEVRVREHAIFQRDGDDLHCEVPIRISQAALGDTVRVATLGGEAEIRIPAETQTGKLFRLRGKGVRSVRSRSEGDLYCRVVVETPVNLTTDQRELLKQFEATFTGEDARKHSPKSATFIDGVKGFWDRMTS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_PSEAE
Sequence: MSESAPTPRRERVIVGMSGGVDSSVSALLLLQQGYQVEGLFMKNWDEDDGTEYCTAREDLADAQAVCDRIGIKLHTANFAAEYWDNVFEHFLAEYKAGRTPNPDILCNREIKFKAFLDYALMLGADLIATGHYVRRRDRDGRTELLKGLDPNKDQSYFLHAVGGEQIARSLFPVGELEKPEVRAIAEKHGLATAKKKDSTGICFIGERRFTDFLKQYLPAQPGDIETTEGKVIGRHSGLMYHTIGQRQGLGIGGLKEAGDDPWYVLGKDLQRNVLLVGQGNDHPLLFSRALLASRIYWVNPVELERPRRLRAKVRYRQSDQDCVLEKTAEGYRAVFDEPQRAVTPGQSVVFYDGDVCLGGGVIETAEAWDFGGRP
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_PECAS
Sequence: MATYSSNDFRSGLKIIFESEPYAIESSEFVKPGKGQAFARVKMRRLLTGSRVEKTFKSTDSLEGADVVDTNMNYLYNDGEFYHFMHPETFEQHQVEEKTVGDSAKWLQDNAECIVTLWDGRPITVLPPNFIEAEITDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQIGEVVRVDTRSGEYVSRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3BP1_HUMAN
Sequence: MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVSNDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQTVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRDQRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFFQSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ
What is the function of this protein?
ATP- and magnesium-dependent helicase that plays an essential role in innate immunity (PubMed:30510222).  Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS.  Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210).  In addition, plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204).  Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278).  Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278).  Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278).  Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510).  Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510).
What are the official names of this protein?
Ras GTPase-activating protein-binding protein 1, G3BP-1, ATP-dependent DNA helicase VIII, hDH VIII, GAP SH3 domain-binding protein 1.
Protein: LDHA_SPHID
Sequence: MSTKEKLINHVMKEEPIGSRNKVTVVGVGMVGMASAVSILLKDLCDELALVDVMEDKLKGEVMDLQHGGLFLKTHKIVGDKDYSVTANSRVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCILMVVSNPVDILTYVAWKLSGFPRHRVIGSGTNLDSARFRHIMGEKLHLHPSSCHGWIVGEHGDSSVPVWSGVNVAGVSLQTLNPKMGAEGDTENWKAVHKMVVDGAYEVIKLKGYTSWAIGMSVADLVESIVKNLHKVHPVSTLVKGMHGVKDEVFLSVPCVLGNSGLTDVIHMTLKPEEEKQLVKSAETLWGVQKELTL
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_SACEN
Sequence: MIPDPRDIILAPVISEKSYGLLEENQYTFLVRPGSNKTEIKIAVEKIFGVKVTNVNTINRQGKRKRTRTGYGKRKDTKRAIVTLSPESKPIEIFGGPAA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: SYH_HELMI
Sequence: MLISAPRGTKDILPGQSRHWQTLEDTIRRLCREYGYEEIRTPIFEHSEVFHRGVGDTTDIVQKETYDFQDRGGRDLTLRPEGTAPTVRALLEHKLYAGSLPVKLYYTGPMFRFGRPQTVRLRQFHQFGIEVFGASGPRVDAEVIAMAMDFYSRLGLKNLELLLNSIGCPACRPAYREALHQFLRPKGGELCEDCKKRMDRNPLRVLDCKNQRCQELSQGAPTTVNHLCDDCANHFADVKELLDAAGVAYSLDDRLVRGLDYYTKTAFEIVSRDIGAQSSIGGGGRYDHLVEALGGPPVPGIGFGLGLERVLLTMKNQGLLDADSREQRDLFIALAGEGTQPVAFGLAQKLRQRGVAVEMDYLERSLKAQMKTADRFRVPYVVIVGEGELKEGKLTLRTMATGEQQQIPLGEAAEYLDNLFANREN
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERC_CHLTR
Sequence: MITSFYAFLDYLKNMKASSLHTLRNYCMDLSSLKCFLEKKSDLSPTPPLSLHDNTYDYPPLSFSLFTKDNIRLYLLEQIQTHHSKRTVRRRLSAIKSFARFCVKNQLIPENPAEMIRGPRLPQELPSPLTYEQVLALMAAPELDKVTGFRDRCLLELFYSSGLRISEITALNRADIDFQSHLLHIRGKGKKERIVPMTKVAVQWLQDYLNHPDRASVEQDHQACFLNRFGKRLSTRSIDRKFQQYLLKTGLSGSITPHTIRHTIATHWLERGMDLKTIQLLLGHTSLETTTIYTHVSMKLKKQIHDETHPHNLEE
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTM2D_ARATH
Sequence: MAARQQQKGTGFGVQYEDFVPKSEWKDQPEATILNIDLTGFAKEQMKVTYVHSSKMIRVTGERPLANRKWNRFNEVFTVPQNCLVDKIHGSFKKNVLTITMPKETITKVAYLPETSRTEAAALEKAAKLEEKRLLEESRRKEKEEEEAKQMKKQLLEEKEALIRKLQEEAKAKEEAEMRKLQEEAKANEEAAAKKLQEEIEAKEKLEERKLEERRLEERKLEDMKLAEEAKLKKIQERKSVDESGEKEKILKPEVVYTKSGHVATPKPESGSGLKSGFGGVGEVVKSAEEKLGNLVEKEKKMGKGIMEKIRRKEITSEEKKLMMNVGVAALVIFALGAYVSYTFCSSSSSSSSSSPSSSSSSTKPE
What is the function of this protein?
Seems to not be involved in heat resistance (By similarity).  Unable to mediate restriction of long-distance movement of the pathogenic tobacco etch virus (TEV) without causing a hypersensitive response or inducing systemic acquired resistance.
What are the official names of this protein?
Inactive protein RESTRICTED TEV MOVEMENT 2, Inactive restricted tobacco etch virus movement protein 2.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Present in sieve elements.
Protein: RNZ_STAA8
Sequence: MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIFITHMHGDHIFGLPGLLSSRSFQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIEIDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTINVEALKNIGLEPGPKYQEVKSHDTFEHNGQVYQSKDFRGESKQGPVVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKHLANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQTLIQNEDTPNFNFVKDFDSFKI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: RL24E_PYRAR
Sequence: MKIYQCAFCGADIPPGYGIMYVKSDGTVLRYCSRKCFVSATKYGRNPRKLAWVRKLQRKQKQSTS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
Protein: ARAA_ECO7I
Sequence: MTIFDNYEVWFVIGSQHLYGPETLRQVTQHAEHVVNALNTEAKLPCKLVLKPLGTTPDEITAICRDANYDDRCAGLVVWLHTFSPAKMWINGLTMLNKPLLQFHTQFNAALPWDSIDMDFMNLNQTAHGGREFGFIGARMRQQHAVVTGHWQDKQAHERIGSWMRQAVSKQDTRHLKVCRFGDNMREVAVTDGDKVAAQIKFGFSVNTWAVGDLVQVVNSISDGDVNALVDEYESCYTMTPATQIHGEKRQNVLEAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQGYGFAGEGDWKTAALLRIMKVMSTGLQGGTSFMEDYTYHFEKDNDLVLGSHMLEVCPSIAVEEKPILDVQHLGIGGKDDPARLIFNTQTGPAIVASLIDLGDRYRLLVNCIDTVKTPHSLPKLPVANALWKAQPDLPTASEAWILAGGAHHTVFSHALNLNDMRQFAEMHDIEITVIDNDTRLPAFKDALRWNEVYYGFRR
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: BUTA_STAEQ
Sequence: MSKTAIITGSAGGLGKGIAERLANDGFNIVLQDINEALLLETEKEFKEKGYQAVAFKSDVSKKKEQEELVQFAVTEFGQLDVMVNNAGVDAVTPILEIGEEELSKLFNINVFGTLFGIQAAANQFIKQKSKGKIINACSIAGHESYEVLGTYSATKHSVRSFTQTAAKELADKGITVNAYCPGVAKTEMWDRIDEEMVKLDDSLEIGDAFEAFSSEIKLGRYQEPSDVANLVSFLASNDSDYITGQSILTDGGLVYR
What is the function of this protein?
Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH.
What are the official names of this protein?
Diacetyl reductase [(S)-acetoin forming], Acetoin(diacetyl) reductase, AR, Meso-2,3-butanediol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MHPD_ECO81
Sequence: MTKHTLEQLAADLRRAAEQGEAIAPLRDLIGIDNAEAAYVILHINVQYDVAQGRRVVGRKVGLTHPKVQQQLGVDQPDFGTLFADMCYGDNETIPFSRVLQPRIEAEIALVLNRDLPATDITFDELYNAIEWVLPALEVVGSRIRDWSIQFVDTVADNASCGVYVIGGPAQRPAGLDLKNCAMKMTRNNEEVSSGRGSECLGHPLNAAVWLARKMASLGEPLRAGDIILTGALGPMVAVNAGDRFEAHIEGIGSVAATFSSAAPKGSLS
What is the function of this protein?
Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.
What are the official names of this protein?
2-keto-4-pentenoate hydratase, 2-hydroxypentadienoic acid hydratase.
What is the protein family that this protein belongs to?
Belongs to the hydratase/decarboxylase family. MhpD subfamily.
Protein: GRCA_EDWI9
Sequence: MIKGIQITKADNADLLNSFWLLDTEKGAARCLCAKGGYAEDQMVALDELGAFESRDVELDVAPSVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVITRTFTQSL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: NADE_BURL3
Sequence: MTSADYASRQRAIIAELNVASEFDAEAEIARRVEFLAQYLRSTGLRTYVLGISGGVDSSTAGRLAQLSVEKLRADGYDARFVAMRLPNGVQNDEADAQRALAFVRADEELTVNVKPAADAMLGALAASGHAFETPAQQDFVHGNIKARERMIAQYAVAGARRGIVIGTDHAAESLMGFFTKFGDGGADILPLAGLNKRRVRAVARALGGEELIVMKVPTADLEELRPLRPDEHAYGVSYDEIDDFLEGKPVADNVYETVLRFYDASRHKRALPYTMFDWPTA
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: GADX_ECO57
Sequence: MQSLHGNCLIAYARHKYILTMVNGEYRYFNGGDLVFADASQIRVDKCVENFVLVSRDTLSLFLPMLKEEALNLHAHKKVSSLLVHHCSRDIPVFQEVAQLSQNKNLRYAEMLRKRALIFALLSVFLEDDHFIPLLLNVLQPNMRTRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQERSAQGLPNRDSAASIVAQGNFYGTDCSAEGIRL
What is the function of this protein?
Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC.  Depending on the conditions (growth phase and medium), can repress gadW (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator GadX.
Protein: CYSI_SHEB2
Sequence: MSEQKLALNEYLKTDSDYLRGTIKEGLDSAVTGSFSDGDQQLIKFHGFYQQDDRDLRNERKEQKLEPLYSFMLRARVPGGICSPQQWLGVDKIASTLTSSNSIRLTTRQTFQYHGIPKRNLKTIIQDLDREALDSIAACGDVNRNVMCNPNPVESKLHEQAYAVAKQLSDHLLPHTRAYAEIWLDEEKLLSTEDETVEPVYGKTYLPRKFKMAVAVPPDNDVDVYTNDLGFIAVAENGELVGFNLTAGGGMGSTHGEVETFPRLADDFGFIKTADVMKFAEAVMTVQRDWGNRVNRKRSRLKYTIVDHGYEKFKAEVELRAGVKFEPKRDVVIGDRGDRYGWVEGVDRKWHLTLFIESGRIKDLPGQTLQTGLREIAKIHKGDFRMTSNQNMIIAGVAAEDKATIEGLARKHGLLGQVLTQTRGHSIACVALPTCPLAMAEAERYFPEFIDHIDALQAKHGISEQAIVVRMTGCPNGCARPFAAEIGLVGKAPGRYNLYLGASFEGTRLNKMHRENIQEAEILAELDTLFGRYAVERDAGETFGNFTVRVGVVKAVIDAAKDFHG
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: RFCS2_MIMIV
Sequence: MFFFEKYRPKKPSDFLFNTDVLRQLKYLASNEDVPHIIISGPSGSGKKTLVKFLLEFLYDEDVNILRKRKYNINGSSTKKEIEILQSNYHIIIEPTSTNHDKYILQEIIKQYAMHKSFDIFKTKRKFKTIVIHNIENLANNSQAALRRTMERYAKTCRFIMVCNNLSKIMDPLRSRCRTFCVPLPTIENINTVVDYIAFMENIKLNKNDTKFILDNCNNNLKTAIWFLNCKGLNCSPFIALDEAFDLVVESILECRTGKNIFKIHNDIRTNIYNILITNIKGSEIINILVDKLIRKIDDDVINMNIIQYASKAEYNLTHGRRDITDIEYFISGVMQELVLNRNKEPEKSEKTKSKTGKLSRTNSKKTIKN
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Putative replication factor C small subunit L478, RFC small subunit L478, Clamp loader small subunit L478.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcS subfamily.
Protein: AROA_THEVB
Sequence: MAVIQITSDDTWQIQADGHPLRGTLQVPGDKSISHRALMLGAMAEGTTQITGLLVGEDTCSTASCFRALGAEISPLNATAVTVQGLGMGRLQEPGDVMNAGNSGTTMRLLLGVLAAQTGRFFTLTGDASLRSRPMARVVTPLLQMGAQIWGRQHHSRAPLAILGQPLEPITYYSPIASAQVKSALLLAALHTEGTTLIREPHRSRDHSERMLQAFGARLSVDEATCTVSLEGPAVLKGQKVIVPGDISSAAFWLVAASIIPDSELLLTNVGVNPTRTGILDVLWAMGAEITLENERLVTGEPVADLRVRSARLKSTRIGGELIPRLIDEIPILAVAAAFAEGVTEIRDAAELRVKESDRLKAVATELQKMGAKVTELSDGLDIQGGGPLQGTHLETYGDHRMAMSLAIAALNAKGTSEIHNASAAAVSYPEFVTVLQQIA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_SHESH
Sequence: MSGNSIGQNFVVTTFGESHGKALGCIIDGCPPGLELNEADMQRDLDRRRPGTSRYTTARREPDEVRVLSGIFEGKTTGTSIGLMIENTDQRSKDYSNIKDLFRPGHADYTYQQKYGLRDYRGGGRSSARETAMRVAAGAVAKKYLKQVHGIEINGYLSQLGPIKADTVDFSQIEQNAFFFPDESKLDELDEYMRKLIKSGDSIGAKVSVVATGVPVGLGEPVFDRLDAEIAHALMGINAVKGVEIGDGFGVVNQKGSEHRDLMSPEGFASNHAGGILGGISSGQPIVAHIAMKPTSSISIPGESMTAQGDVAEVVTKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRHRAQNMDVNSQTPEIGMR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: YAA1_SCHPO
Sequence: MVVHTGNRLNKLRELMKERGYTLYVVPSEDAHSSEYTCDADARRAFISGFDGSAGCAVIGETSAALFTDGRYFNQASQQLDENWTLMKQGFTGVPTWEEYCTQMTKCNEKVGIDSSLITFPAAKALRESLFLKSGAVLVGDHDNLVDIVWGASRPKEPLEKLIVQEIKYAGLGVDEKLHNLREAMKEQKIEAFVVSMLDEVAWLYNLRGADVPYNPVFFAYSLVTLDEAFLYVDERKVTPEVSKHLDGFVKILPYDRVFSDAKNSNLTRIGISSKTSWCIATSFGETKVMPILSPISQAKGIKNDAELKGMKECHIRDGCALVEYFAWLDEYLNSGNKINEFDAATKLEQFRRKNNLFMGLSFETISSTGPNGAVIHYSPPATGSAIIDPTKIYLCDSGAQYKDGTTDVTRTWHFGEPSEFERQTATLALKGHIALANIVFPKGTTGYMIDVLARQYLWKYGLDYLHGTGHGVGSFLNVHELPVGIGSREVFNSAPLQAGMVTSNEPGFYEDGHFGYRVENCVYITEVNTENRFAGRTYLGLKDLTLAPHCQKLIDPSLLSPEEVKYLNEYHSEVYTTLSPMLSVSAKKWLSKHTSPI
What are the official names of this protein?
Uncharacterized peptidase C22G7.01c.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: ECTD_BORBR
Sequence: MISPAQDPYASRTDRSSAIIARQDPVVYGEGKFADALSADQVQSYERDGFLLLENLFSDEEVAALLAEVERMTRDPAIVRREEAITEPGSNAVRSIFMVHVLSPILGRLVRDPRLANAARQILGSEVYVHQSRANMKPGFKGKEFYWHSDFETWHVEDGMPSMRALSCSVLLTDNNETNGPLMLVPGSHRQFISCVGETPRDHYKQSLKKQEYGVPDPVSLQLLAEQGGISTMTGKAGSVVFFDCNTMHGSNSNISPWPRANVFMVYNSMENTLNPPKYGLNPRPEHIATRQAFKAVRPLDSLKLVER
What is the function of this protein?
Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte.  Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.
What are the official names of this protein?
Ectoine dioxygenase, Ectoine hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the PhyH family. EctD subfamily.
Protein: TILS_PHOPR
Sequence: MLYSSLRSSLLANIPHSNRFVIALSGGLDSRVLLHLMGRFIQENPQYQCDAVHVHHGLSVNADKWAQQCLQWAFEEKITCHIEHVTLVLGNRISVEQQAREQRYLALSKHVQQGDCLLTAQHADDQLETFLLALKRGSGPAGLASMPESTTFGISYHLRPLLQVTRQSITDYGIAHQLEWVEDESNQDQRYDRNFLRHQITPLLHQRWPGIRKAVSRSAALCGEQEALLNELLASHLSKALHVDQSLKIVELGSERIGKQLIRQWLSLFTVLMPSQAQLQQIWQSVVLAQDDANPQVCWDNHQIRRYKQRLYVVKQWADISLFQQKCELNQACSLPEGLGTLVLTTVKANGILRLPQQHEIVSVRFEPEGIEAKPQGRIGKRKLKKLFQEYEVPSWNRRRTPLVFYNDRLAAVAGLFVTEDFFGEDCDLDWLCNS
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGS22_MOUSE
Sequence: MPEKRLSAEPPEVTEEEFENYLATDNFLVDYFNEFLSLPTFPEAIRFNVDYGVFEVVNDAPQLLEKQLKKILQNQQPRNPIYDVVRKGKSDSKSTQKSVPCEDEAINVNYSIMCLKREQGINWIKRERLPAFLESDCYFEYRLAKLISQATWSSTGMNFIVGTNFTPWILRRPPAPPPPSTDEDNYMIMKKFYVSLGQASYTQTKDWFTLAKESENTVTMASLPCCIPHHQTASPVIATASEIFDDGVHPRTIKSLSKSSKAVSELDEEEEGSISMKDSPSQALLRVYLEKKGGKERNLTLHFSSVEEFLDAYIIFILREAIQHITGQSLSDTPEYINYYKVSHVIFDKVPPVPSNKAIVSPPVEMVEEISKDRLENVSLSSESESIGPESRADWCISHRTYDIGNRREFERFKKFLKGTLGERYWWLWMDIERLKVLKDPERHQRHLEKMKKCYLVSSGERYLSAEILSKFKLLHGSRWTADHLKNIQAEVLKPLLLYWAPRFCVTHSASAKNASTELKFWRLRQEKPRKDVDPFPQMATLLPLRPKSCIPQTPEVQGEEINLFQPSKFKKLSKINAGTQQLGRSEPLNAVSSKDGGLEKGSKRLPESTTVVRLTSFTDISECLKPQLERKYTYTEEHNVKTVSNVGALGGFDMENLLQSLYVENRAGFFFTKFCENSGNKLWKHSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYMKIQPPFEDLFDTAEEFILLSLLEPWTQMVMSDKMAYKKVELQEETRQLDSACFRKLHALHKETISKKAEDTTGYAMAKLSLSDVSKQTEYWLNVPEGYKHFTFTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYIKNKYLNKKYFFGPRSPASLHQQNQIMLLSGGWGRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASRQKIKTQMKDIADELLLQRHDRKIGVWKPVESKWISSSCEIIAFRKALLNPVIARQFQRFVALKGDLLENGVLFWQEVQKFKDLCHSHCDESIIHKKITTIINCFINSYIPPALQIDIPVEQAQKILEHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDEKIMSVLERRQEHKQKRKASDTEEDKAGKSGVKQYASTTGSLTKPVLGSESLLVLQSYGRQPTWCYSKYIEALEQERILLKIQEEVERKMFTGTSSFTNLLKPSTGSALSLKKNVSLHSIQR
What is the function of this protein?
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
What are the official names of this protein?
Regulator of G-protein signaling 22.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.
Protein: MURF_TREPA
Sequence: MLLSFDEVCAAVQGARVCDARGARGFDGVSFDSRAVVPRDLFIPLRGAHVDGHTFVEEALQKGAVATLIDQRYPHAGEYVAWCTRFGAACIAVHDTLRALQDLASFYCKKFPALIRIGITGSSGKTTVKEMARAVFSERYRVVATPGNLNSEIGLPQSLFFVRAEHEVGIFELGMNRRGEMRTLAQILVPHYAIITNVGCAHVGILGTQQAIAEEKKEIFSQFTEHSVGFVPDDAYRVFLSNIPYGRVVVYDQGGRGLATEVIDEGLRGSRVLYQGRWIRVPLPGVHNAKNALAVIALAAQVGLPAEEIQRGMERVKPPFGRSHVVCASLTFLLDCYNANPDSMAAALHLCAHISAVSKVYVLGDMGELGVTAAEAHYRVCVLAAASDARAVYVFGPEFCRAVRKVSWGRKRVYAFALEELSALQETLDAQLRRGDFVLVKGSRSVALERLEPLLRKER
What is the function of this protein?
Involved in cell wall formation.  Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
What are the official names of this protein?
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase, D-alanyl-D-alanine-adding enzyme, UDP-MurNAc-pentapeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAJC_RICTY
Sequence: MSQHTQDNQINNNETIEIQETDTVPIETNSLQSGLTSLIPMILIFAVFYFLLLRPQEQRRKEREKLVREVKKGEEVLTNSGIYGIVTKVSENDNNIEIEIAKDVRIKAIKSSIIDITSRKKEVAATQENNKKNKKVICAKSS
What is the function of this protein?
The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes.  While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
What are the official names of this protein?
Sec translocon accessory complex subunit YajC.
What is the protein family that this protein belongs to?
Belongs to the YajC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.