PharMolix/UniProtQA huggingface dataset:
Protein: EIF3L_COCIM
Sequence: MSVDARTAYPGSRPPANMQDESDVEEEALVNNYKEQVHFDDGMSELDRTTSLGAASQTQGLQAQLAAAATPLEFQATLETKFASYDNYCSLFHYILNSDGPVDLEVPSYYWAWDVIDEFIYQFESFCRYRNRVARTGSNEEEAQLLRENPNTWGCYSVLNVLYSLIQRSQINEQLAAIKANEDPMAVAGDYGSRPLYRMLGYFSIIGLLRVHCLLGDFSLALKTLDDIEMNKKAMFARVMAAHFTTYYYVGFSYMMMRRYADAIRTFSHILVYVSRTKNFQKGRESYDAIAKKNDQILALIAICVSFHPTRLDDTIHSGLREKYGDQFIRLQRGGPDALPLYEELFRSACPKFISPTPPDFDNPALNIDPVDHHTAVFMDEVRNTLYNPTVKSYLKLYTTMDLKKLAGFLEVEPEQLRSWLLVNKLRSRQVRWSEGGLLEGEIVNSSDLDYAIEGNLIHISETKAGRRLVDWYLRNLARTY
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit L, eIF3l.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOIL1_DANRE
Sequence: MSLSSGGWTRASPPAQSSSSHLGHEASQSACSTVLMSVKVSVCHSGIRPLCLPGAGDESLRLQLSMDPGKAGEFRLALRDISATAAGRSVFIAEFDLKTVQYEVKTPLCHELSLATPPHDRISFKFRCEQEAQEWATVVMSSLREAHRVAISSSTEEGRLPPPPLATQSKAPMPRTEEICAELVSAIEAGDVRSASVCASSLAKQKAALSIQPSKRNYTDSEVCLAVVVEDASSSCCVSVKVFPHSTIGALKQQVFSDYGFHPRVQRWVIGQSLCSDHRSLASYGVQRDGDTAFLYLISARQARLSRGIYQQDQESALLMVPTTHQAHQEAVSNGPAALNTASRPYSTLPTRLHNSHNTLSNNAGGSERLGLSDIRDLINLELPQLNEALGPNRTSIQPGWACPTCTYINKPTRPGCEMCSADRPEGYTVPGNYRPDALELRRIQQEKEAIRQYQQARETERRENFARLVQMDGQDLVPNPERVECRICYVELESGEGVLLRECLHCFCKECLRSVILMSEDPQVACPYRDESYACDCVLQEREIRALVSVDDYQHWLQRGLSVAESRCEGSYHCATADCPGWCVYEDTVNTFHCPVCKKQNCLLCKAIHEGMNCKQYQDDLTARAINDSAARRTRDLLKTLVNSGEAMHCPQCGIIVQKKEGCDWLRCTVCHTEICWVTRGPRWGPKGPGDISGGCRCNVNKQRCHPKCQNCH
What is the function of this protein?
Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (By similarity).  LUBAC conjugates linear polyubiquitin to ikbkg and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity).  Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (By similarity).  LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) to conjugate linear polyubiquitin to ikbkg and possibly other components contributing to the stability of the complex (By similarity).  The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity).  LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity).  The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity).  Binds polyubiquitin of different linkage types (By similarity).
What are the official names of this protein?
RanBP-type and C3HC4-type zinc finger-containing protein 1, Heme-oxidized IRP2 ubiquitin ligase 1 homolog, HOIL-1, Heme-oxidized IRP2 ubiquitin transferase 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the RBR family.
Protein: S35A4_MOUSE
Sequence: MSVEDGGVPGLARPRQARWTLLLFLSTAMYGAHAPFLALCHVDGRVPFRPSSAVLLTELTKLLLCAFSLLVGWQTWPQGTPPWRQAVPFALSALLYGANNNLVIYLQRYMDPSTYQVLSNLKIGSTALLYCLCLGHRLSARQGLALLLLMAAGACYASGGFQEPVNTLPGPASAAGAHPMPLHITPLGLLLLILYCLISGLSSVYTELIMKRQRLPLALQNLFLYTFGVILNFGLYAGSGPGPGFLEGFSGWAVLVVLNQAVNGLLMSAVMKHGSSITRLFIVSCSLVVNAVLSAVLLQLQLTAIFFLAALLIGLAVCLYYGSP
What is the function of this protein?
Mediates the transport of CDP-ribitol (By similarity).  Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (By similarity).
What are the official names of this protein?
Probable UDP-sugar transporter protein SLC35A4, Solute carrier family 35 member A4.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: H4_EUPCR
Sequence: MPGRGKGGKGGKGYGKVGAKRHAKKALRETILGVTKPAIRRLARRGGVKRISSLVYEETRAVLKGFLESVIRDSVTYTEHAKRKTVTALDVVYALKRQGKTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ALBU_MACMU
Sequence: LLFLFSSAYSRGVFRRDTHKSEVAHRFKDLGEEHFKGLVLVAFSQYLQQCPFEEHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPPLVRPEVDVMCTAFHDNEATFLKKYLYEVARRHPYFYAPELLFFAARYKAAFAECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGDRAFKAWAVARLSQKFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYMCENQDSISSKLKECCDKPLLEKSHCLAEVENDEMPADLPSLAADYVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVMLLLRLAKAYEATLEKCCAAADPHECYAKVFDEFQPLVEEPQNLVKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGAKCCKLPEAKRMPCAEDYLSVVLNRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSALELDEAYVPKAFNAETFTFHADMCTLSEKEKQVKKQTALVELVKHKPKATKEQLKGVMDNFAAFVEKCCKADDKEACFAEEGPKFVAASQAALA
What is the function of this protein?
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs.  Its main function is the regulation of the colloidal osmotic pressure of blood.  Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity).  Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).  Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity).  The shared binding site between zinc and calcium at residue Asp-265 suggests a crosstalk between zinc and calcium transport in the blood (By similarity).  The rank order of affinity is zinc > calcium > magnesium (By similarity).  Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E. coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E. coli (By similarity).  Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
What are the official names of this protein?
Albumin.
What is the protein family that this protein belongs to?
Belongs to the ALB/AFP/VDB family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRC_ECO27
Sequence: MTAPSQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSVDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVKQ
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: TRPB_NEIM0
Sequence: MKNYHAPDEKGFFGEHGGLYVSETLIPALQELADAYKAAKNDPEFWAEFRCDLKHYVGRPSPVYHAARLSEHLGGAQIWLKREDLNHTGAHKVNNTIGQALLAKRMGKKRVIAETGAGQHGVASATVAARFGMTCDVYMGADDIQRQMPNVFRMKLLGANVVGVESGSRTLKDAMNEAMREWVARVDDTFYIIGTAAGPAPYPEMVRDFQCVIGNEAKAQMQEAIGRQPDVAVACVGGGSNAIGLFHPYIGEENVRLVGVEAGGLGVNTPDHAAPITSGAPIGVLHGFRSYLMQDENGQVLGTHSVSAGLDYPGIGPEHSHLHDIKRVEYTVAKDDEALEAFDLLCRFEGIIPALESSHAVAWAVKNAPKMGKDQVILVNLSGRGDKDINTVAKLKGIKL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: UBI2P_PETCR
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGDF
What is the function of this protein?
Ubiquitin exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Polyubiquitin.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CCMH_ORYSI
Sequence: MATEEDVKQRQIIESRARNISHNVRCTECGSQSIEDSQADIAILLRKLIRDEIKSGKSDKEIYKKLQADYGETILYTPKFDLQTAAIWLSPVIVGGVAAGVWAYKKHRQRTNVHIMALNLVRGVPLTPREKETMLDVLTPPPPANKWWWPGK
What is the function of this protein?
Plays a role in mitochondrial cytochrome c maturation.  Probable component of a heme lyase complex involved in the reduction of apocytochrome c.
What are the official names of this protein?
Cytochrome c-type biogenesis CcmH-like mitochondrial protein, OsCCMH.
What is the protein family that this protein belongs to?
Belongs to the CcmH/CycL/Ccl2/NrfF family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PANB_ARTS2
Sequence: MATSNSSDSSMSAEVPAPYGNGPANAPATPSDTAKKPVARIRTHHLQQAKDKGEHFAMLTAYEQYTAEIFDEAGIEVLLVGDSASNNVFGNETSLPVTVDELLPLCRAVARSAKRALVVADLPFGSYEVSAEQAVATGVRFLKEGLAHAVKIEGGKFYADTVRAMVQAGIPVMAHIGFTPQSEHSLGGYRVQGRGDDAQRLIDDAVALAEAGAFSVLMEMVPAATAAAVDAAIAVPTVGIGAGNTTTGQVLVWQDMAGLRGGKMAKFVKQYADLRTSLSNAAKAYGDDVRTGQFPGPEHSF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTRE_METVS
Sequence: MDPTLISLGALALAGAAATVSGCAEDLESDVGSQSNPNSQVQLGPQMGNIHRYFNKAISGEPVSYGLYVAVAGSVAWALINAGLNAVLALIIGSGVAAIVHGAYSVSAFLGRTVGQSQKFGQPVYMDVLTSHIGPIVGHGFIAVFTMVLAAYLAVTALGNPFPLPLVALIFGITVGAIGSSTGDVHYGAEREYQKYAFGGGIPVANQGDIDIYAEYGIRNGLDSSYFCSRLGGPLTGLCFGLIIFLDGWRSIVGNIIGGDLVTKTSIALVVGLLVVVAAMILNRKIEVFARNKYGPYRN
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit E, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E.
What is the protein family that this protein belongs to?
Belongs to the MtrE family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HTPX_HAEIE
Sequence: MMRILLFLATNMAVMLVLGIILSVTGIAGNSTGGILIMALLFGFAGSLISLFLSKTMALRSVDGEVITQPRNQTERWLIDTVSRQAQKAGIPMPDVAIYHSPDVNAFATGATKSNSLVAVSTGLLNNMTEAEAEAVLAHEISHISNGDMVTMALLQGVLNTFVIFLSRVIATAVASSRNNNGEETRSSGIYFLVSMVLEMLFGVLASIIAMWFSRYREFRADAGSASLVGKEKMIMALQRLQQLHEHQNLEGSLNAFMINGKRSELFMSHPPLEKRIEALRNL
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UVRA_PAULE
Sequence: MRKKTDLHSHGTSEKQIEGFVQVRGAREHNLKDVHLDIPRNALVVFTGISGSGKSSLAFGTLYAEAQRRYLESVSPYARRLFHQMSVPEVDSIEGLPPAIALQQQRGAPTTRSSVGSITTLSNSLRMLYSRAGNYPKGQDILYAESFSPNTPEGACPTCHGLGRVYEVTEQSMVPDDSKTIRERAIAAWPPAWHGQNLRDILTTLGYDIDIPWRDLPKKDRKWILFTEEQPVVPVYAGFTLDEVRHALKRKETPSYQGTFTSARKYVLDTFANTESPAMKKRVSQYMVGKECTLCQGKRLRPESLAVTFAGYDITELSRLPLKHLATLLHPYAQENTPDWDKLAAKNPEKAIVTQRIAEDLSNRLSVLLSLGLGYLTLERSTPTLSPGELQRLRLATQVHSNLFGVVYVLDEPSAGLHPADTQALLAALDRLKQAGNSLFVVEHALGVIRHADWIVDVGPEAGEHGGRILYSGPPQGLSEVAESHTRRYLFPDKEADIFAKQPSRSPQGWLQVAGVTRNNLDNLTAAFPLGVLTSVSGVSGSGKSSLVSQVLVELVSKALGQELVAEAEQGESIEHDTPATLGGRITAGMESIKRLVTVDQKPIGRTPRSNLATYTGLFDHVRKLFASTRAAKARHYDAGRFSFNVAKGRCGNCEGEGFVMVELLFLPSVYAPCPVCKGTRFNAKTLEI
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrA is an ATPase and a DNA-binding protein.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity).
What are the official names of this protein?
UvrABC system protein A, UvrA protein, Excinuclease ABC subunit A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. UvrA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Z652B_XENLA
Sequence: MVVDDPCLLNIPTSFYHSTNQELDLSNKTFKREVGGPYSVMMDNKIGKPHLLETDQQNFFQDSKPTNEVHAVKGERENSGESEEEEDEDDDDDDDDDDDDEEGEDEDEVNYKREQIIVEVNLNNQTLNVSKGDKGVPKDPSQIKTSSDDEGGDSGEDDQDSHEDEENNPLPLDGQTNMQHGNQDQKTENSDMVGGDGTIPANSTKEQGKGGEAPKRKKKPKSPSDKAKSEEKETLTCDKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSLHLQTDCEKNIQCITCNKTFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHLVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGMRFRFSNMLKAHKEKCFRVTSPVGVPPALQITLNNPTLSNPSQGISNLPNAHIPPPSPTPPLNLNALNPLPPRPIPHPFSHLHLHPHSHTHHLAVPPVPHLPPPPALFKSEALNHRGQNDDSFLRHLAEKTSAGQHH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 652-B.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL34_STRE4
Sequence: MKRTYQPSKIRRQRKHGFRHRMSTKNGRRVLASRRRKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RPOB_CORDI
Sequence: MVNIAGPPPREVLEGPILAVSRQTKANIPGAPERKSFAKITEPIEVPGLLDIQLNSFAWLIGTPEWRARQQEELGDSVRVTSGLEDILEELSPIQDYSGNMSLSLSEPRFEDMKNTIDECKDKDINYSAPLYVTAEFINNETQEIKSQTVFIGDFPMMTDKGTFIVNGTERVVVSQLVRSPGVYFDQTIDKSTERPLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWTTEQITERFGFSEIMMSTLESDGVSNTDEALLEIYRKQRPGEQPTRDLAQSLLDNSFFRAKRYDLAKVGRYKVNRKLGLGGDNEGLMTLTEEDIATTLEYLVRLHAGETTMTSPTGEVIPVETDDIDHFGNRRLRTVGELIQNQVRVGLSRMERVVRERMTTQDAESITPTSLINVRPVSAAIREFFGTSQLSQFMDQNNSLSGLTHKRRLSALGPGGLSRERAGIEVRDVHASHYGRMCPIETPEGPNIGLIGSLASYARVNAFGFIETPYRKVENGVLTDQIDYLTADEEDRFVVAQANVEHDADGKITADSVTVRVKNGDIQVVAPESVDYLDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPFVGTGMERAAAYDAGDLIINKKGGVVENVSADIITVMADDGTRETYILRKFERTNQGTCYNQTPLVNIGDRVEAGQVLADGPGTHNGEMSLGRNLLVAFMPWEGHNYEDAIILNQRVVEEDILTSIHIEEHEIDARDTKLGPEEITREIPNVSEDVLKDLDERGIVRIGADVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSMKVPHGETGKVIGVRRFSRDDDDDLAPGVNEMIRVYVAQKRKIQDGDKLAGRHGNKGVVGKILPQEDMPFMPDGTPVDIILNTHGVPRRMNIGQVLEVHLGWLAAAGWKIDTEDPANAELLKTLPEDLYDVPAGSLTATPVFDGATNEEIAGLLGNSRPNRDGDVMVDENGKATLFDGRSGEPFPYPVSVGYMYILKLHHLVDEKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWAMQAYGAAYTLQELLTIKSDDVVGRVKVYEAIVKGENIPDPGIPESFKVLLKELQSLCLNVEVLSADGTPMELSGSDDDEFDQAGASLGINLSRDERSDADIA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: GLGX_ECOHS
Sequence: MTQLAIGKPAPLGAHYDGQGVNFTLFSVHAERVELCVFDANGQEHRYDLPGHSGDIWHGYLPDARPGLRYGYRVHGPWQPAEGHRFNPAKLLIDPCARQIDGEFKDNPLLHAGHNEPDYRDNAAIAPKCVVVVDHYDWEDDAPPRTPWGSTIIYEAHVKGLTYLHPEIPVEIRGTYKALGHPVMINYLKQLGITALELLPVAQFASEPRLQRMGLSNYWGYNPVAMFALHPAYACSPETALDEFRDAIKALHKAGIEVILDIVLNHSAELDLDGPLFSLRGIDNRSYYWIREDGDYHNWTGCGNTLNLSHPAVVDYASACLRYWVETCHVDGFRFDLAAVMGRTPEFRQDAPLFTAIQNCPVLSQVKLIAEPWDIAPGGYQVGNFPPLFAEWNDHFRDAARRFWLHYDLPLGAFAGRFAASSDVFKRNGRLPSAAINLVTAHDGFTLRDCVCFNHKHNEANGEENRDGTNNNYSNNHGKEGLGGTLDLVERRRDSIHALLTTLLLSQGTPMLLAGDEHGHSQHGNNNAYCQDNQLTWLDWSQASSGLTAFTAALIHLRKRIPALVENRWWEEGDGNVRWLNRYAQPLSTDEWQNGPKQLQILLSDRFLIAINATLEVTEIVLPAGEWHAIPPFAGEDNPVITAVWQGPAHGLCVFQR
What is the function of this protein?
Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin.
What are the official names of this protein?
Glycogen debranching enzyme, Limit dextrin alpha-1,6-maltotetraose-hydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: PRP3_ECOLI
Sequence: MSWRLVYASTVGTSHISADLPCQDACQMQIAWLNDQQPLLSVFVADGAGSVSQGGEGAMLAVNEAMAYMSQKVQGGELGLNDVLATNMVLTIRQRLFAEAEAKELAVRDFACTFLGLISSPDGTLIMQIGDGGVVVDLGHGLQLPLTPMAGEYANMTHFITDEDAVSRLETFTSTGRAHKVAAFTDGIQRLALNMLDNSPHVPFFTPFFNGLAAATQEQLDLLPELLKQFLSSPAVNERTDDDKTLALALWAE
What is the function of this protein?
PP2C-like phosphatase that can dephosphorylate YegI.  In vitro, can hydrolyze p-nitrophenyl phosphate (pNPP) to p-nitrophenol.
What are the official names of this protein?
Serine/threonine-protein phosphatase 3, PP2C-like Ser/Thr phosphatase, Protein phosphatase C.
Protein: APLD1_RAT
Sequence: MEKWTAWEPQGADALRRFQGLLLDRRGRLHCQVLRLREVARRLERLRRRSLAANVAGSSLSAAGALAAIVGLSLSPVTLGASLVASAVGLGVATAGGAVTITSDLSLIFCNSREVRRVQEIAATCQDQMRELLSCLEFFCQWQGRGDRQLLQSGRDASMALYNSVYFIVFFGSRGFLIPRRAEGATKVSQAVLKAKIQKLSESLESCTGALDELSEQLESRVQLCTKAGRGHNLRNSPDLDAALFF
What is the function of this protein?
May be involved in angiogenesis.  May play a role in activity-dependent changes of brain vasculature.  May affect blood-brain permeability.
What are the official names of this protein?
Apolipoprotein L domain-containing protein 1, Vascular early response gene protein.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RHBD3_HUMAN
Sequence: MHARGPHGQLSPALPLASSVLMLLMSTLWLVGAGPGLVLAPELLLDPWQVHRLLTHALGHTALPGLLLSLLLLPTVGWQQECHLGTLRFLHASALLALASGLLAVLLAGLGLSSAAGSCGYMPVHLAMLAGEGHRPRRPRGALPPWLSPWLLLALTPLLSSEPPFLQLLCGLLAGLAYAAGAFRWLEPSERRLQVLQEGVLCRTLAGCWPLRLLATPGSLAELPVTHPAGVRPPIPGPPYVASPDLWSHWEDSALPPPSLRPVQPTWEGSSEAGLDWAGASFSPGTPMWAALDEQMLQEGIQASLLDGPAQEPQSAPWLSKSSVSSLRLQQLERMGFPTEQAVVALAATGRVEGAVSLLVGGQVGTETLVTHGKGGPAHSEGPGPP
What are the official names of this protein?
Rhomboid domain-containing protein 3.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GPX1_YEAST
Sequence: MQEFYSFSPIDENGNPFPFNSLRNKVVLIVNVASHCAFTPQYKELEYLYEKYKSHGLVIVAFPCGQFGNQEFEKDKEINKFCQDKYGVTFPILHKIRCNGQKQDPVYKFLKNSVSGKSGIKMIKWNFEKFVVDRNGKVVKRFSCMTRPLELCPIIEELLNQPPEEQI
What is the function of this protein?
Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress (PubMed:10480913, PubMed:11445588).  Has peroxidase activity using thioredoxin or glutathione as a reducing power (PubMed:20572871, PubMed:22659048).  Involved in peroxisome formation (PubMed:22659048).
What are the official names of this protein?
Glutathione peroxidase-like peroxiredoxin 1, Glutathione peroxidase homolog 1, GPx 1.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Peroxisome matrix. Mitochondrion outer membrane; Peripheral membrane protein.
Protein: RL2_STRTD
Sequence: MGIKVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVSLKNKAGRNNNGRITVRHQGGGHKRHYRLIDFKRNKDGVEAVVKTIEYDPNRTANIALVHYTDGVKAYIIAPKGLEVGQRIVSGPDADIKVGNALPLANIPVGTVIHNIELKPGKGAELVRAAGASAQVLGQEGKYVLVRLQSGEVRMILGTCRATIGTVGNEQQSLINLGKAGRNRWKGVRPTVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNEK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DCD_ECO8A
Sequence: MRLCDRDIEAWLDEGRLSINPRPPVERINGATVDVRLGNKFRTFRGHTAAFIDLSGPKDEVSAALDRVMSDEIVLDEGEAFYLHPGELALAVTLESVTLPADLVGWLDGRSSLARLGLMVHVTAHRIDPGWSGCIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAARPYNRREDAKYRNQQGAVASRIDKD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: IF2A_ARCFU
Sequence: MKEKRLIIKRSGYPSKGEIVIGTVKRVLDFGAFVSLDEYEGREGMVHISEVASGWIKDIREHVKKGQKVICKVLDVNPKRGHIDLSIKDVNERQRREKLQQWKNEMKAFKWLEIIGEKLNIDFKELEKIGKKLMKEYDSVYSAFEEAAFEGYEVLAPIVGEEFAKEMAEIARENIKPKRVKVRGYFELKSSASDGIERIKKALLEAKKALVNGVEMKLEYVGAPKYRIVVEADDYKTAENVLKKATENVLKAIKKLGGEGNFIREAA
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit alpha, aIF2-alpha, eIF-2-alpha.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-alpha family.
Protein: RS8_RICM5
Sequence: MSMTDNVADMLTRIRNAYKSKLINVSFPSSKIKISILDVLQKEGYIKDYITTQKNNISYTEVALKYSVNGDASICEIHRVSKPGKRVYSPIKDLKGYYNNMGIYILSTPYGVMSDREAHIKNVGGEVICKVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.