PharMolix/UniProtQA huggingface dataset:
Protein: RSMH_BORT9
Sequence: MGNIFHIPVLLEEIINLLEASNISDGFVFVDCTLGEGGHSSAVLKKYQNINVIGIDRDDVVLNRAKESLIEFKGRVSYFNTWFDDFFSEYPLSSKINFILADLGISMFHYKMSGRGFSFFEDERLDMRLYPGAGGLSAYDIINTFDKKRLENLIYELSGERYSRRIVKSILEYRKIKKIETPRELQDIVSKAYPRIKLKINPATKTFQALRIYVNDELFRLKRSLPLWVESLSNNGVLAIVTFHSLEDKIVKEFFKGLSKDQYCILTKKPIMPRCEEKRFNSASRSAKLRVIKKLYE
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEMA_LIRTU
Sequence: MPKKKALTPLPYLASIVFLPWWISISFNKSLEPWVTNWWNTRQSETFLNDIQEKNVLERFIELEQLFLLDEMIKEYPGTQIQKLRIGIHKETIQLVKMHNEDHIHIILHFSTNIICFAILSGYSILGNEELVILNSWVQEFLYNLSDTIKAFSILLLTDLCIGFHSPHGWELMIGSVYKDFGFAHNDQIISGLVSTFPVILDTILKYWIFHYLNRVSPSLVVVYHSMNE
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
What are the official names of this protein?
Chloroplast envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: UBIG_ACTP7
Sequence: MNNIDQTELDKFEKMAATWWDPNGSFKPIHLLNPLRLDYIQQKANGLFGKKVLDVGCGGGILSEAMAKAGANVTGIDMTTEPLDVARKHAEESGLTIDYRQTTIEDFVQNQTACHAEKFDVITCMEMLEHVPDPLSIIQSCKALLKPDGVLFFSTINRTLKAYMLVIIGAEYVLKMLPKGTHEFEKFIKPAELLNWCDMANLRCQEMKGYHFNPLTEKFWLNNDVSCNYIAMLK
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: PROB_STRPB
Sequence: MGMMKRQFEDVTRIVIKIGTSSLVLPTGKINLEKIDQLAFVISSLMNKGKEVILVSSGAMGFGLDILKMEKRPTNLAKQQAVSSVGQVAMMSLYSQIFAHYQTNVSQILLTRDVVVFPESLANVTNAFESLISLGIVPIVNENDAVSVDEMDHATKFGDNDRLSAVVAGITKADLLIMLSDIDGLFDKNPTIYEDAQLRSHVAVITQEIIASAGGAGSKFGTGGMLSKIQSAQMVFENKGQMVLMNGANPRDILRVLEGQPLGTWFKQIEEVTHD
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_BACVZ
Sequence: MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSGVATLKKYFDGRVVPENPRIVNAQKSIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKEEAITWAWEFLTSEKWIGFDPELLSVTVHPEDEEAYTLWAEKIGVPEERIIRLEGNFWDIGEGPSGPNTEIFYDRGEKYGNDPSDSELYPGGENDRYLEVWNLVFSEFNHNPDGTYTPLPKKNIDTGMGLERMVSVIQDVSTNFDTDLFMPIIEATERISGDAYGKDAVKDTAFKVIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTLGISRPFMYELVPTVAGIMDAFYPEVKEKQEFIAKVIKTEEERFHETLNEGLAILSDVIKKEKEKGSGIISGKDVFKLYDTYGFPVELTEEYAEDEQMTVDHKGFEAEMEKQRERARNARQDVGSMQVQGGALRDITAESTFVGYSAVKAEAKVIELLHDGQLISEAHEGDTVQILLDKTPFYAESGGQIGDRGVLRSEQAVVTIKDVKKAPNGQHVHEGTVDSGTIQKGASVTAEVEDQMRSGVVKNHTATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELERIEGIVNEKIWESIPVAIDLKPINEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVTNTAEIGLFKIVSESGIGAGTRRIEAVTGKGAYQEMNSQLSLLQHAADELKSNVKDVPKRIQSLQAELKEAQRENESLLSKLGNVEAGAILSKVKDIGGVKVLAEKVNAKDMNHLRTMVDDLKAKLGSAVIILGAVQNEKVNLSAGVTKDLIEKGLHAGKMVKQAAEVCGGGGGGRPDMAQAGGKHPEKLEEALASAVDWIKSVL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_AERS4
Sequence: MTDKTSLSYKDAGVDIDAGNALVERIKGVSKRTRRPEVLGGLGGFGALCQIPAGYKEPVLVSGTDGVGTKLRLAIDLKKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDTAAAVVTGIGVGCEQSGCALVGGETAEMPGMYEGEDYDIAGFCVGVVEKSEIIDGSKVGDGDALIALAASGPHSNGFSLVRKILEVSKADVHQPLGDTTLASALLEPTRIYVKPVLKLIKECEIHALSHITGGGFWENIPRVLPANTQAVIDEQSWQWPAVFSWLQQAGNVTRHEMYRTFNCGVGMIIALPADQLEKALTLLKAEGENAWHIGHIAKAVDGEEQVIIQ
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNPT1_HUMAN
Sequence: MAACRYCCSCLRLRPLSDGPFLLPRRDRALTQLQVRALWSSAGSRAVAVDLGNRKLEISSGKLARFADGSAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDYRQKAAAAGRIPTNYLRREIGTSDKEILTSRIIDRSIRPLFPAGYFYDTQVLCNLLAVDGVNEPDVLAINGASVALSLSDIPWNGPVGAVRIGIIDGEYVVNPTRKEMSSSTLNLVVAGAPKSQIVMLEASAENILQQDFCHAIKVGVKYTQQIIQGIQQLVKETGVTKRTPQKLFTPSPEIVKYTHKLAMERLYAVFTDYEHDKVSRDEAVNKIRLDTEEQLKEKFPEADPYEIIESFNVVAKEVFRSIVLNEYKRCDGRDLTSLRNVSCEVDMFKTLHGSALFQRGQTQVLCTVTFDSLESGIKSDQVITAINGIKDKNFMLHYEFPPYATNEIGKVTGLNRRELGHGALAEKALYPVIPRDFPFTIRVTSEVLESNGSSSMASACGGSLALMDSGVPISSAVAGVAIGLVTKTDPEKGEIEDYRLLTDILGIEDYNGDMDFKIAGTNKGITALQADIKLPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRASRKENGPVVETVQVPLSKRAKFVGPGGYNLKKLQAETGVTISQVDEETFSVFAPTPSAMHEARDFITEICKDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNTQLDQRKIKHPTALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVVRTLNDRSSIVMGEPISQSSSNSQ
What is the function of this protein?
RNA-binding protein implicated in numerous RNA metabolic processes.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction.  Mitochondrial intermembrane factor with RNA-processing exoribonulease activity.  Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner.  Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381).  Required for correct processing and polyadenylation of mitochondrial mRNAs.  Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix.  Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels.  In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells.  Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially.  Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs.  Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase 1, mitochondrial, 3'-5' RNA exonuclease OLD35, PNPase old-35, Polynucleotide phosphorylase 1, PNPase 1, Polynucleotide phosphorylase-like protein.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion matrix. Mitochondrion intermembrane space; Peripheral membrane protein.
Protein: RIHA_SHISS
Sequence: MALPILLDCDPGHDDAIAIVLALASPELDVKAITSSAGNQTPEKTLRNVLRMLTLLNRTDIPVAGGAVKPLMRELIIADNVHGESGLDGPALPEPTFAPQNCTAVELMAKTLRESAEPVTIVSTGPQTNVALLLNSHPELHSKIARIVIMGGAMGLGNWTPAAEFNIYVDPEAAEIVFQSGIPVVMAGLDVTHKAQIHVEDTERFRAIGNPVSTIVAELLDFFLEYHKDEKWGFVGAPLHDPCTIAWLLKPELFTTVERWVGVETQGKYSQGMTVVDYYYLTGNKPNATVMVDVDRQGFVDLLADRLKFYA
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihA, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihA subfamily.
Protein: MUTS_TRIL1
Sequence: MSSALQTPMMRQYLEIKAQHPESILFFRMGDFYEMFLDDALVASRILDITLTSRNKNSADEIPFCGVPFHSAQPYIARLVEAGYRVAVCEQIEDPKQTKGLVKRDVVKVVTPALVTESESLTPDENSFLLALCSSGQRWGCAWLDLSTGEFLTANSDNLAGAATLLASIAPRELLLPDQLRRDLPPELALVAGDRPRAAVADWVLDKDYCSKLICSQFGVASPEMLGLAVTELSEALLATGMVLHYLQENRHATLPHLRDLTIVRQNDHLALDPATRRNLELTATMTDNKKSGSLLGCLDRTATAMGARTLKQWLSYPLVQVAPIRRRLEAVEELKENPALQDQLREQLKGVHDLERLNGRVSMAGAGGRDLRSLHDSLEQVPQIRLALTEATAPLLRDLTEELDPLQDIRSLINQAIAPAPPFSLREGGIIADGYHAELDELRAISREGKGYIARMEAQERDRTGISSLKIRYNKVFGYYIEVTKSNLSSVPDNYIRRQTIATGERYITEELKSYEEKVLGAEDRICELEYTLFQEVRERTAAQGGRVSRTASALASLDVLASLALVAQERDYCKPVVDDGDTLEIIEGRHPVVEAMNLGERFVPNDTRLDQEQHQLLMITGPNMAGKSTYMRQVALITLMAQVGSFVPASRATIGIADQIFTRVGAGDNLARGQSTFMVEMMETAHILRSATTKSLVVLDEIGRGTSTFDGLSIAWAVAEYLHDTNHCKARTLFATHYHELADLAATREGITNLTVAVKEWNDQVIFLRTIIPGAASHSYGIQVARLAGMPRNVIERAKEVLKTLEEGEFEQGSPRLSKSSIAPPRKETAQFTLFEQQGDLLRERLKKLNISVMTPLEALNLLDELKKMA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: 3MGH_BURCH
Sequence: MRRSKTAAPWPGTIVPRAFFNRMATEVAPQLLNKILAAADGRAGRIVEVEAYAGALDPAAHTYRGKTPRNATMFGPPGHFYVYFTYGMHWCCNCVCGPDGAGTGVLIRALEPLHGLEQMRAARPPRTRDRDLCRGPARLTQAMGIGGAQDGVDLVGARDGFAIVDDGMAPPADLAGGPRIGIRVGQDLPWRWSVPGNRYVSGAVPRI
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: KAIC_NOSS1
Sequence: MSEKEQQEQQNTSGNGVEKIRTMIEGFDDISHGGLPVGRTTLVSGTSGTGKTLLSLQFLFNGISFFDEPGVFVTFEESPSDIIKNAHIFGWNLQRLINEGKLFILDASPDPEGQDIVGNFDLSALIERLQYAIRKYKAKRVSIDSITAVFQQYEAVGVVRREIFRLVARLKQLNVTTIITTERSEEYGPVASFGVEEFVSDNVVIARNVLEGERRRRTIEILKLRGTTHMKGEYPFTITNDGVNIFPLGAMRLTQRSSNVRVSSGVKTLDGMCGGGFFKDSIILATGATGTGKTLLVSKFLQNGCVNNERAILFAYEESRAQLSRNAYSWGIDFEELESQGLLKIICTYPESTGLEDHLQIIKSEIAYFKPARIAIDSLSALARGVSNNAFRQFVIGVTGYAKQEEITGFFTNTTDQFMGSHSITDSHISTITDTILMLQYVEIRGEMSRAINVFKMRGSWHDKGIREYNITADGPEIQDSFRNYERIVSGSPTRVSIDEKAELSRIVRRFEDKQGSDS
What is the function of this protein?
Has a weak, temperature-independent ATPase activity; ATPase activity defines the circadian period.  The phosphorylation state of KaiC modulates its ATPase activity and effects KaiB binding.
What are the official names of this protein?
Circadian clock oscillator protein KaiC.
What is the protein family that this protein belongs to?
Belongs to the KaiC family.
Protein: INH3_TABYA
Sequence: MTLKRIFCAALALIVLQSVASAVDYCRLSCPEGRDHVGCRNAGFGAHCGSNPQTPKLHQEHIKMVLQKTNWLRGVVAEGSFCYPKAARMPVLVWDDDLANLASLHTKGCVTETNKCRSTERFHSPGQSSYEISGDTLPSAMDILNFALRDWYLQKDNLTRKDIGSYPAGEDKGLKNMANLISDKVTAIGCGLTHWEEGKLKRALFTCNFSSSNVPGHPIYQRGDNFATKCAKTHPYYKSLCNSDEHIKPNNNV
What is the function of this protein?
Inhibits platelet aggregation induced by all agonists tested (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and snake venom snaclecs (TMVA that activates platelet through GPIB, and stejnulxin that specifically acts through GPVI (GP6))) (PubMed:19531497).  May act by competing with fibrinogen for binding to glycoprotein IIb/IIIa (ITGA2B/ITGB3) (PubMed:19531497).
What are the official names of this protein?
Tabinhibitin 3.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: MNMA_SYNS3
Sequence: MSAEAKMTTSTATQAGAEALERLRQWPGEHRVAVGLSGGVDSSLTAALMVEAGWEVEGLTLWLMSGKGACCAEGLVDAAGICQQLGVPHHVVDSRDTFVREIVQGLVDGYRAGITPLPCSKCNRSVKFGPMLAWAEQERNLPRIATGHYARIRLDREDGRWKLLRGLDRRKDQSYFLYDLPQEVLARVVFPLGELTKADTRLEAGRHGLRTADKPESQDLCLADHHGSMRAFLDAYIPPRDGEIVLQDGTVVGQHDGIEHFTIGQRKGLGIAWSEPLHVVKLDAAMNQVVVATRAEAGRTGCEVGAMNWVSIAPPPLDSPMEVEVQVRYRSEPVRAHLICIEATANDRAKERPHRCKLTFQEPQFSITPGQGAVLYDGEVVLGGGLIDSPV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX3_THEPA
Sequence: MRNSAQSYLKYINIINIFETLYLFYSTGLDTLEYIDSTYKNFIIMYVNQYLLYGTTLKYLSVGEFFMNSLTIFINSIREIMTSTTMVMYAIFGMFIFSEILVFSTFIWGYFHLRLSNPILLAELNVEAYLQISDVLNTGSILVSIILHRVQESANFETDFFMEQLLLIGFIFLSLQNDEYSLILSYVNNYWMTLYFFILTGLHSLHVCAGGIFVLIQSYFYEGDGSQRDEEFNAGVYWHFVEMIWIALTMLLFLA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPOZ_LISMF
Sequence: MLYPSIDNLLLKIDSKYSLVTVAAKRARYMQLENDKGVLPSYQSDKFVGKALEEIHAGKLVLQNDDK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: SYV_HISS2
Sequence: MTKQFTMEDRFNPSAVEQALYQHWESRGYFKPSEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGKRLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLANGAKTAEGLDYLVVATTRPETMLGDTAVAVHPEDERYQSLIGKTVVLPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAEIIGTDGKPLAGYDAPIPADYQGLERFVARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVENGEIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQGNVYVARDEAEVRSKYGLTSDVALKQDEDVLDTWFSSGLWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFIKDENGKPQVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDGISLEDLLEKRTGNMMQPQLAEKIAKATRKEFEHGISAHGTDALRFTLAALASNGRDINWDMKRLEGYRNFCNKLWNASRYVLTHEKLDLSEGEAEYSLADRWIESQFNRTIDAFRTALKQYRFDLVANTIYDFTWNQFCDWYLELTKPVFAHGTDAQKRGTSRMLLNILEKLLRLAHPIIPFITEEIWQKLKGVMKLSGDTIMLQPFPHAEESKFDPVAESQMDWLKEVIVAVRNIRAECNISPSHALELLLRNISEETKICLENNRTLLQSMAKLSTITLLDANEEPPLSVTKLVENNEIFIPMAGFINKEQELTRLTKEIEKLKGEIVRIENKLSNEAFITKAPEQVIAKEREKMQGYLDNIEKLQQQYQAIETL
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA_BACC0
Sequence: MTTIDLNCDLGESFGAYKMGNDDEILPFVSSINVACGFHAGDPSVMRQTVEKAMQHNVAIGAHPGFPDLIGFGRRNMNVSANEVYDYVLYQIGALDAFVKAAGGKMQHVKPHGALYNMAATNPEIADAIAKAIYHMNSSLSLYGLANSEAFIQAAEKYNITLVQEAFADRTYKQDGTLTSRTEENALIKNEDEAINQVLQMVKEGYVNSVNGEKVAVQAQTICLHGDGEKAVQFARKIYRIFERNKISICAPK
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: PSIT2_PSICY
Sequence: MSPERSASLEPDEHSSLLSDTASYISRDDLEDSKAKQIPTPIPKKQLGVLFSIRFTEPIIYSHLWPYINQFVNDIGVADGNPRYVGFYSGLIESVFACGEVCSIFMLSRLSDRIGRRPVLLPSALGVALFTALFGLSTSFTMMLVLRVCAGLLAGATPIVHSVVSELTDETNNALVVPLYGLITPIGFAIGPLIGGTLEHAATKYPNVFGYDFLRKYPYFLPSFVPCCLAVVGVTFGYFFLQETLPSIVRAKKRLERQKSTSSISSRTSTLYGATDDHNRDASESTALSPEEAEDEIDSKPQSIKALIVDPSMRAIMGSGTFLMFLYTSSDVLFSLYCFTAVEDGGVGLPPDEIGYAFSVAGVIAMLMQLCITPWVLRTFDKAKVYKFCMFSFPLVFALMGCLNPLAQTGYNEVSKTIHPTTTGLLYAAIAVLLLLARVCVMAFPISMMLIKQNADKNSLATANGLVQVSMTIARALCPTVSSSLFAYSTSNNILGGHLWVLIMVTISLAGVWQSMSIARVTKRKEEL
What is the function of this protein?
Major facilitator-type transporter; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product.
What are the official names of this protein?
Major facilitator-type transporter psiT2, Psilocybin biosynthesis cluster transporter 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HTPG_PSEFS
Sequence: MTMSVETQKETLGFQTEVKQLLHLMIHSLYSNKEIFLRELISNASDAVDKLRFEALSKPELLEGGAELKIRVSFDKDAKTVTLEDNGIGMSREDAITHLGTIAKSGTADFMKNLSGDQKKDSHLIGQFGVGFYSAFIVADKVEVFSRRAGLDASEGVHWSSKGEGEFEIATVDKADRGTRIVLHLKDGEDEFADGWRLRNIVKKYSDHIALPIELPKEQAAAEGEETPAQEWEVVNRASALWTRPRTEIKDEEYQEFYKHIGHDYENPLSWSHNKVEGKLEYSSLLYVPARAPFDLYQREAPKGLKLYVQRVFVMDQAESFLPLYLRFIKGVVDSNDLSLNVSREILQKDPIIDSMKSALTKRVLDMLEKLAKNEPEQYKGFWKNFGQVMKEGPAEDFANKEKIAGLLRFASTQGDDGEQVVSLAEYLARAKEGQDKIYYLTGETYAQVKNSPHLEVFRKKGIEVLLLTDRIDEWLMSYLNEFDGKSFVDVARGDLDLGNLDSEEEKKEAEEVAKSKEGLVERIKASLGDAVSEVRVSHRLTDSPAILAIGEQDLGMQMRQILEASGQKVPDSKPIFEFNPAHPLIEKLDGEQSEERFGDLSHILFDQAALAAGDSLKDPAAYVRRLNKLLVELSV
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_CUPTR
Sequence: MIALIQRVAQARVTVAGRTTGEIGAGLLALVCAERGDTEAQAERLLAKMLSYRVFSDADGKMNLPVQNMDGNGNPGGLLVVSQFTLAADTNSGTRPSFTPAASPEDGRRLYEHFVAQARAAHPQVQTGEFGAMMQVSLVNDGPVTFWLRVPPA
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLC_MAIZE
Sequence: MALSASRVQQAEELLQRPAERQLMRSQLAAAARSINWSYALFWSISDTQPGVLTWTDGFYNGEVKTRKISNSVELTSDQLVMQRSDQLRELYEALLSGEGDRRAAPARPAGSLSPEDLGDTEWYYVVSMTYAFRPGQGLPGRSFASDEHVWLCNAHLAGSKAFPRALLAKSASIQSILCIPVMGGVLELGTTDTVPEAPDLVSRATAAFWEPQCPSSSPSGRANETGEAAADDGTFAFEELDHNNGMDDIEAMTAAGGHGQEEELRLREAEALSDDASLEHITKEIEEFYSLCDEMDLQALPLPLEDGWTVDASNFEVPCSSPQPAPPPVDRATANVAADASRAPVYGSRATSFMAWTRSSQQSSCSDDAAPAAVVPAIEEPQRLLKKVVAGGGAWESCGGATGAAQEMSGTGTKNHVMSERKRREKLNEMFLVLKSLLPSIHRVNKASILAETIAYLKELQRRVQELESSREPASRPSETTTRLITRPSRGNNESVRKEVCAGSKRKSPELGRDDVERPPVLTMDAGTSNVTVTVSDKDVLLEVQCRWEELLMTRVFDAIKSLHLDVLSVQASAPDGFMGLKIRAQFAGSGAVVPWMISEALRKAIGKR
What is the function of this protein?
Putative transcriptional activator.  Controls tissue-specific synthesis of anthocyanin pigments in various parts of the maize plant.
What are the official names of this protein?
Anthocyanin regulatory Lc protein.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PCFT_CHICK
Sequence: MAAPSDPPTAATPPAPPPPARRCLLAPSVEPLLFLATLALGLQVPLATQYLWDRLGAERGYVGPNASSPHGCGNGSGAVDPLREEVEALVAHWNLCINLGGFFVGLFSVTLFGPWSDSVGRRPVLVLPAVGMAVQAAVYLLVMYLRLHVAYLLLGRIISGLLGDYNLILAGCFASVADSSNQRTRTFRVAILEACLGVAGMVASVGGGQWRKAEGYINPFWLVLAASLAAALYAALCLQETVKQRRAAKLLTLQHYKAVYKLYTAPEDLSSRRKLALYSLAFFLLVTVHFGTKDLYVLYELGSPLCWASDLIGYGSAASYLAYLSSLGGLRLLQLCLEDTWVAEIGLISNIAGLVVISLATTTPLMFTGYGIMFLSMAATPVIRAKLSKLVGETEQGALFASVACVEGLCSLVATGVFNSLYPSTLHFMRGFPFLFGAILLLIPAAIMGWIEIQDSNLQYSHFSDASSSPADG
What is the function of this protein?
Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:34040256).  Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:34040256).  Functions at acidic pH via alternate outward- and inward-open conformation states (PubMed:34040256).  Protonation of residues in the outward open state primes the protein for transport (PubMed:34040256).  Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (PubMed:34040256).  Also able to transport antifolate drugs, such as methotrexate and pemetrexed (PubMed:34040256).  Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity).  Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (By similarity).
What are the official names of this protein?
Proton-coupled folate transporter, Solute carrier family 46 member 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SLC46A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endosome membrane; Multi- pass membrane protein. Cytoplasm. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity). Localizes to the basolateral membrane of choroid plexus (By similarity).