PharMolix/UniProtQA huggingface dataset:
Protein: GATC_STACT
Sequence: MARVSREEVEHIANLSKLHISPEETTEMQDTLETILNFAQQIDTADTSSVEPTYHVLDLQNVLREDKAIPGIPQSLALKNAKETEDGQFKVPSIISGEDA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: PGH1_RAT
Sequence: MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCDCTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIWEFVNATFIREVLMRLVITVRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDIHLLAQRLLLRREFIPGPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDSLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPEKQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIALEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSFQEFTGEKEMAAELEELYGDIDALEFYPGLMLEKCQPNSLFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNIVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPSTEL
What is the function of this protein?
Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response.  The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes.  This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins.  The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons.  Involved in the constitutive production of prostanoids in particular in the stomach and platelets.  In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection.  In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.  Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products.
What are the official names of this protein?
Prostaglandin G/H synthase 1, Cyclooxygenase-1, COX-1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin-endoperoxide synthase 1.
What is the protein family that this protein belongs to?
Belongs to the prostaglandin G/H synthase family.
What are the subcellular locations of this protein?
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: BSCL2_MOUSE
Sequence: MVNDPPVPALLWAQEVGHVLAGRARRLMLQFGVLFCTILLLLWVSVFLYGSFYYSYMPTVSHLSPVHFHYRTDCDSSTASLCSFPVANVSLAKSGRDRVLMYGQPYRVTLELELPESPVNQDLGMFLVTVSCYTRGGRIISTSSRSVMLHYRSQLLQVLDTLLFSSLLLFGFAEQKQLLEVELYSDYRENSYVPTTGAIIEIHSKRIQMYGAYLRIHAHFTGLRYLLYNFPMTCAFVGVASNFTFLSVIVLFSYMQWVWGAVWPRHRFSLQVNIRQRDNSHHGAPRRISRHQPGQESTQQSDVTEDGESPEDPSGTEGQLSEEEKPEKRPLNGEEEQEPEASDGSWEDAALLTEANPPTSASASALAPETLGSLRQRPTCSSS
What is the function of this protein?
Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). In association with LDAF1, defines the sites of LD formation in the ER (By similarity).  Also required for growth and maturation of small nascent LDs into larger mature LDs (By similarity).  Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (By similarity).  Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (By similarity).  Binds anionic phospholipids including phosphatidic acid (By similarity).  Plays an important role in the differentiation and development of adipocytes (PubMed:18458148, PubMed:19574402, PubMed:21551454, PubMed:22269949).
What are the official names of this protein?
Seipin, Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the seipin family.
Protein: MNTH_CLOAB
Sequence: MDKLSIREDNYNIKHKTISLNRASSVTRNLKGLLKFLGPAFVVSVAYIDPGNFATNISGGSSFNYNLIWVILWSNLMAIFLQTMSAKLGIATGCSLPEMCAKVFSKRANWIFWIVGELGAMATDLAEFIGGTLGLYLLFRIPMIYAGLLTGVLTFIIVYMEKYGQKMVETIIAALIAVICVAYTIELFLARPAWTQVGMHTLIPSLPNGEAVLIAVGMLGATVMPHVIYLHSELVQHRNTNSSDKEKLHHLKMEKIDILIAMNIAFVVNAAMVIVSAAVFFKHGIKVSTIEEAHRSLQPLLGNLSSGAFGIALLASGLSSSAVGTMAGQTIMKGFVNLSIPINLRRIITMLPALIIIALGINPMRVLVLSQVALSFILPFPIIQMLLIAGRKDLMGILVNKKFTKIVGFIIATMIILLNIILLYLTFTGQT
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RRAA_SHIDS
Sequence: MKYDTSELCDIYQEDVNVVEPLFSNFGGRASFGGQIITVKCFEDNGLLYDLLEQNGRGRVLVVDGGGSVRRALVDAELARLAVQNEWEGLVIYGAVHQVDDLEELDIGIQAMAAIPVGAAGEGIGESDVRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_STRA5
Sequence: MTNDFHHITVLLHETVDMLDIKPDGIYVDATLGGAGHSEYLLSQLGPDGHLYAFDQDQKAIDNAHIRLKKYVDTGQVTFIKDNFRNLSSNLKALGVSEINGICYDLGVSSPQLDERERGFSYKQDAPLDMRMNREQSLTAYDVVNTYSYHDLVRIFFKYGEDKFSKQIARKIEQVRAEKTISTTTELAEIIKSSKSAKELKKKGHPAKQIFQAIRIEVNDELGAADESIQQAMDLLAVDGRISVITFHSLEDRLTKQLFKEASTVEVPKGLPFIPDDLQPKMELVNRKPILPSQEELEANNRAHSAKLRVARRIR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_CHRVO
Sequence: MAKKIVGYIKLQVPAGKANPSPPIGPALGQRGLNIMEFCKAFNAQTQGMEPGMPIPVVITAYADKSFTFTMKTPPATFLLKKAAGIKSGSAKAHVDKVGKVTRAQLEEIAKTKQADLTAADLDAAVRTIAGSARSMGLEVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RL35_THEFY
Sequence: MPKNKSHSGASRRFRVTGTGKIMRRRTNKNHLLEHKPSKRTRRLSVDVRVSPADARKIRKLLG
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: COABC_HAEIN
Sequence: MKLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAVSQSLLDPQAELAMGHIELAKWADAIIIAPASADFIARLTIGMANDLLSTICLATNAPIFLAPAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGDMGKGRMSEPEEIFTALSDFFSQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLIAGPVNLTTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVTEVAEQKIKKSGDEISIKLIKNPDIISDVGHLKTHRPFTVGFAAETQNVDDYAKDKLERKNLDMICANDVSGGQVFNADENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL
What is the function of this protein?
Catalyzes two sequential steps in the biosynthesis of coenzyme A.  In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine.  In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
What are the official names of this protein?
Coenzyme A biosynthesis bifunctional protein CoaBC, DNA/pantothenate metabolism flavoprotein, Phosphopantothenoylcysteine synthetase/decarboxylase, PPCS-PPCDC.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PPC synthetase family.
Protein: MURG_ANADF
Sequence: MRMLIAGGGTGGHVFPGIALAEEVVGRHPGNDVVFVGTERGLEAKVVPAAGFPIELIDVKGLKGKGILSLLLNLLLVPRALLQSHRILRKWRPDVVVGVGGYASGPVVLVAWLLRIPTAVQEQNAIAGFTNRVLGRFVDAAFTAFPEAARHFAGRKVYQLGNPIRRTLMENYMRPEVKHPRPRMLVFGGSQGAHALNMRVIEALPHLADLREALAVTHQTGARDREQVEKGYRACGFEPDVREFIHDMSAAYAGADLVVCRAGATTLAELTVCKKPAILVPFPAAADNHQVVNARSLVVAGAAVMIEERDLTGELLAAEIRAILTHPERRERMARAAGRLGSPQAAKEIADVCAELVRRRWGSPAGQERPGHGPVRPPDLA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BLH1_YEAST
Sequence: MLPTSVSRSLYLKTFRSHLLRAPQIVLKRMSSSIDISKINSWNKEFQSDLTHQLATTVLKNYNADDALLNKTRLQKQDNRVFNTVVSTDSTPVTNQKSSGRCWLFAATNQLRLNVLSELNLKEFELSQAYLFFYDKLEKANYFLDQIVSSADQDIDSRLVQYLLAAPTEDGGQYSMFLNLVKKYGLIPKDLYGDLPYSTTASRKWNSLLTTKLREFAETLRTALKERSADDSIIVTLREQMQREIFRLMSLFMDIPPVQPNEQFTWEYVDKDKKIHTIKSTPLEFASKYAKLDPSTPVSLINDPRHPYGKLIKIDRLGNVLGGDAVIYLNVDNETLSKLVVKRLQNNKAVFFGSHTPKFMDKKTGVMDIELWNYPAIGYNLPQQKASRIRYHESLMTHAMLITGCHVDETSKLPLRYRVENSWGKDSGKDGLYVMTQKYFEEYCFQIVVDINELPKELASKFTSGKEEPIVLPIWDPMGALAK
What is the function of this protein?
The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells.  Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid.  Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin.  Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.  Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.
What are the official names of this protein?
Cysteine proteinase 1, mitochondrial, Bleomycin hydrolase, BLM hydrolase, Homocysteine-thiolactonase, HTLase, Hcy-thiolactonase, Leucine aminopeptidase 3, Y3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
[Isoform Cytoplasmic]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion.
Protein: STEEP_XENLA
Sequence: MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRARVIGAAKHAHKFCNTEEEEPVYLRRSDGIERQYRKKCSKCSLLLFYQHSQKNAAATFIVNGALVKFGQGFGKTSIYTQKPDPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK
What is the function of this protein?
Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity).  Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (By similarity).
What are the official names of this protein?
STING ER exit protein, STEEP.
What is the protein family that this protein belongs to?
Belongs to the STEEP1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Detected in the nucleus and cell soma of various neuronal types.
Protein: AMPA_CLOPE
Sequence: MYNFLVKKSKCTETDALLIPYFEEKTNIPNEEINNKINILKKKEQFKGSYGEIFNITRTTDDNIQDIILLGLGKETEITKEKIRRAFGKAVNEIKRLKSKSVFLRFDSVEAIGLENTLKAMVEGLALGSYSFNKYKSDKKEEVEVTVHIGGHNINEEEVELCEKAIDEAMLLSETTCLARDLVNEPANNMYPETLAKEVKNIGSKYGFEVEVFDENQIEELKMESFLSVGKGSDNLPRLIVMRYFGDKDNMDQRLALVGKGLTYDSGGYSLKTNAGMVTMKADMGGAASVIGAISAIAKRNLKINVIAVVAACENLISGHAYKPGDIIGSMEGKTIEILNTDAEGRLTLIDAVTYAIEKEKASEIIDVATLTGAAVVSLGEDVTAVITNKDEFYGELREASYETGEKVWQMPSFEDYGKLIKSNIADLKNIGGKYAGTITAGLFIGEFIQNKPWLHLDIAGPAFSEKKGDYCPTGGTGAGVRTLYELANRRCK
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_SHEB8
Sequence: MKVVEVKHPLVRHKIGLMREGDISTKRFRELAAEVGSLLTYEATADFETETVTIEGWNGPVEVDQIKGKKVTVVPILRAGLGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFEKLASDMNERIALVVDPMLATGGSMIATVDLLKKRGCTSIKALVLVAAPEGIKALEAAHPDIELYTAAIDKCLNEKGYILPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: RPSB_BACAN
Sequence: MEIQSQPTNLTKEDVIKLIAEFQQNQCGEAQERLVDHYKNLVYSIAYRYSKGGPMHEDIIQVGMLGLLGAIRRYDYSIGNAFEPFAIPTIVGEIKKYLRDKTWGIHVPRRIKDLGGKIKLAIEELTDHLQRSPKIIEIADHLGLSEEEVLEIMDAKNNYRVSSLDDVVENASDGSSVARIESVGEVEQGYEQTERRLVLKDIFNVLNETEKSVIHYIFEENLNQKDTGERLGISQMHVSRIKRQAISKLKQAAFLDT
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
What are the official names of this protein?
RNA polymerase sigma-B factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. SigB subfamily.
Protein: ACTT6_ALTAL
Sequence: MTYFTIKSAAMSPDDDAPSPDINSLGRLMSHSEVESRGNGYEVLQQAGTVRILLSRPERGNALSLSLARDLTRLFQTFSAQHSVHRIVLTGKGKYFCSGMDLGEELYEDATERCLALQDLFGAIDACPKTTIAVINGPAFGGGVGLAFVCDIRVAVSTSFFCLSEVKLGLCPATVSRFIVREWGVSLARMAMLTARKIQPQTLHEMGVLHAVALDEEALEAVTRDVLNDLRFAAPQATAWCKVLTRKTRNANSDHDQLARQIFEAMVVAGSESEYGVAQFRLGNKNICWEQVECRHIG
What is the function of this protein?
Enoyl-CoA hydratase; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) ACT-toxins responsible for brown spot of tangerine disease by the tangerine pathotype which affects tangerines and mandarins (PubMed:19271978).  ACT-toxins consist of three moieties, 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA), valine and a polyketide (PubMed:22846083).  ACT-toxin I is toxic to both citrus and pear; toxin II the 5''-deoxy derivative of ACT-toxin I, is highly toxic to pear and slightly toxic to citrus (PubMed:22846083).  On cellular level, ACT-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).  The acyl-CoA ligase ACTT1, the hydrolase ACTT2, the enoyl-CoA hydratases ACTT3 and ACTT6, and the acyl-CoA synthetase ACTT5 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) structural moiety (PubMed:18944496, PubMed:18986255, PubMed:19271978).  The exact role of each enzyme, and of additional enzymes identified within the AF-toxin clusters have still to be determined (PubMed:18944496, PubMed:18986255, PubMed:19271978).  On the other hand, ACTTS1 to ACTTS4 are specific to the tangerine pathotype (PubMed:22846083).  The function of ACTTS3 is to elongate the polyketide chain portion of ACT-toxin that is unique to this toxin (PubMed:20192828).  The enoyl-reductase ACTTS2 might complement the missing enoyl-reductase (ER) domain in ACTTS3 in the synthesis of the polyketide portion of ACT-toxin (PubMed:20055645).  The roles of the nonribosomal peptide synthetases-related proteins ACTTS1 and ACTTS4 have also still not been elucidated (PubMed:22846083).
What are the official names of this protein?
Enoyl-CoA hydratase ACTT6, ACT-toxin biosynthesis protein 6.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: TXPR1_ALOMR
Sequence: GYCAEKGIRCDDIHCCTGLKCKCNASGYNCVCRKK
What is the function of this protein?
Inhibits P2RX3 receptors.  Has an analgesic effect in rat.  Enhances the high-affinity desensitization of P2RX3 purinoceptors.  At 50 nM, decreases the IC(50) for ambient ATP from 46. 5 nM to 12. 7 nM in mouse P2RX3.
What are the official names of this protein?
Purotoxin-1, PT1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 33 family.
What are the subcellular locations of this protein?
Secreted.
Protein: D89S1_PYRHO
Sequence: MKVQYECLTCMANQCQRIVEMATQDMDIRRRAMILAAKLLAKEYNENAIPAIAGSLIFLELYKFLGNDDPFIEYKLKSEEMARKVADIIKRKLKLDFELAVKLAIIGNVIDFSVGFSPEDLEEEVEKMLKDKLYIDDSKELFEEVKRAENILYITDNVGEHYFDAILIEKIREISNAEVYIAGKEGPIINDATVEDLKRAGLEKLGKVISTGTRIVGVPLKLVSREFMEAFNKADVIIAKGQGNFETLSEINDSRIFFLLKAKCPAVARELKVPKGALVCMRNKFKL
What is the function of this protein?
Metal-dependent phosphatase with probable damage-control functions (PubMed:27322068).  Shows phosphatase activity against p-nitrophenyl phosphate (pNPP), but natural substrates have not been identified yet (PubMed:27322068).  Low phosphatase activity against 8-oxo nucleotides suggests that it could hydrolyze oxidatively damaged purine nucleotides or their biosynthetic intermediates (PubMed:27322068).
What are the official names of this protein?
Damage-control phosphatase PH1575, Nucleotides phosphatase PH1575.
What is the protein family that this protein belongs to?
Belongs to the damage-control phosphatase family. Nucleotides phosphatase I subfamily.
Protein: SSB1_PSEPU
Sequence: MARGVNKVILIGTCGQDPEVRYLPNGNAVTNLSLATSEQWTDKQTGQKVEKTERHRVSLFGKVAEIAGEYLRKGSQVYIEGKLQTREWEKDGIKRYTTEIVVDMQGTMQLLGGRPQNQDGTNQAQQQRRPQQPAPQPQPAYDPMDDDIPFMDPYRFSCLLQ
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: ATPB_ECO5E
Sequence: MATGKIVQVIGAVVDVEFPQDAVPRVYDALEVQNGNERLVLEVQQQLGGGIVRTIAMGSSDGLRRGLDVKDLEHPIEVPVGKATLGRIMNVLGEPVDMKGEIGEEERWAIHRAAPSYEELSNSQELLETGIKVIDLMCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMTDSNVIDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRQIASLGIYPAVDPLDSTSRQLDPLVVGQEHYDTARGVQSILQRYQELKDIIAILGMDELSEEDKLVVARARKIQRFLSQPFFVAEVFTGSPGKYVSLKDTIRGFKGIMEGEYDHLPEQAFYMVGSIEEAVEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AROA_YERRU
Sequence: MLESLTLQPIALINGTVNLPGSKSVSNRALLLAALAEGTTRLHNLLDSDDIRHMLNALKSLGVNYRLSADRTQCDVDGLGGPLVADKTLELFLGNAGTAMRPLAAALCLGYSDIVLTGEERMKERPIGHLVDALEGGAQIDYLEQENYPPLRIRGGFRGGELTVDGSVSSQFLTALLMAAPLATQDTHIRIQGDLVSRPYIDITLHLMRSFGVEVTHQNYQVFHIQGGQTYHSPGEYLVEGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGAIIHWGDDYIECSRGELRDIDMDMNHIPDAAMTIATAALFAKGPTIIRNIYNWRVKETDRLSAMATELRKVGAEVEEGQDYIRVVPPAHLIAAEIGTYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARLSVLA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAA_RHOPA
Sequence: MDARSDLHHYNPYRVFSRAEWASMREDTPMTLDAAEVAALRSMHDRLDLSEVEEIYLPMSRLLSIHVAAMQQLYYAQRRFLGVVERKMPFIIGVAGSVAVGKSTTARVLQALLARWSPRPTVDLVTTDGFLHPNAVLERAGLMQKKGFPESYDLPALLGFLSDIKSGRRKVKAPIYSHLTYDIVPNKFTVIDRPDILIVEGVNVLQTGRLPRDGKAVPVVSDFFDFSVYLDADEPVLRDWYVRRFLALRDTAFHDPRSYFHRYAVLSDEEATATAIAIWERTNLANLEDNILPTRPRATLILKKGADHVVDSVALRRL
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_SHIB3
Sequence: MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFIRISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIPVVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRIDVLALPLPQQRLAGREGPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKGSQQSVEQAYAEAGQPQHKVTEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGAAKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRAARA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DAD4_YARLI
Sequence: MENPHEKDQSDALARIISGVSKLNSSIARVNEIQEEVYSRNLNLSVVSEIMQNYQASVDYYLRESGAMKEPFKNDD
What is the function of this protein?
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
What are the official names of this protein?
DASH complex subunit DAD4, Outer kinetochore protein DAD4.
What is the protein family that this protein belongs to?
Belongs to the DASH complex DAD4 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.