PharMolix/UniProtQA huggingface dataset:
Protein: RUVB1_KLULA
Sequence: MVQISEVQEQSSTAYTRTAAHTHIKGLGLDEFGVAKQVEGGFVGQAEAREACGVIVDLIKAKKMSGKAILLAGGPSTGKTALALAISQELGPKVPFCPLVGSELYSVEVKKTEALMENFRRAIGLRIKETKEVYEGEVTELTPEEAENPLGGYGKTISHVIVGLKSAKGTKTLRLDPTIYESIQREKVSVGDVIYIESNTGAVKRVGRSDAFATEFDLEAEEYVPLPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDVISMMGQLMKPKKTEITEKLRHEVNKVVAKYIDQGVAELVPGVLFIDEVNMLDIEIFTYLNRALESDIAPVVVLASNRGMITVRGTDDVVSPHGVPPDLIDRLLIVRTLPYNREEIKTIISKRAAVENLQVEDEALEFLATLGTETSLRYVLQLLSPSGIIAKIANRAEISVADVEEAKLLFLDAKRSTKILEQSENYL
What is the function of this protein?
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.  The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair.  Also involved in pre-rRNA processing (By similarity).
What are the official names of this protein?
RuvB-like helicase 1.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MORN2_HUMAN
Sequence: MNGFGRLEHFSGAVYEGQFKDNMFHGLGTYTFPNGAKYTGNFNENRVEGEGEYTDIQGLEWSGNFHFTAAPDLKLKLHM
What is the function of this protein?
Might have a role in spermatogenesis.
What are the official names of this protein?
MORN repeat-containing protein 2, MORN motif protein in testis.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Nucleus. Note=Associated with the acrosome during post-meiotic stages of spermatogenesis. Appears to migrate to the nucleus during the final step of spermiogenesis.
Protein: NPLB_XENLA
Sequence: MAFTGKRLKGLIAATFTPMTPNSDINLLVIEQYVDYLVQKQHIRNIFVNGTTGEGMSLSICERKRLTEEWVKHARGKMDNVIVHVGCLGLSDSKDLAAHAASCGADAISAVCPSFLKPANLDALVLYLKDVASAAPSLPFYYYHIPKLTGITYQIYELLGKVKENIPSFRGVKFSDVNLMDFSLCVSEYKEFDCLYGVDEQLLGALAFGAHGAVGSTYNYLGNKNGDMLEAFEAGNLQKARKIQCSLQEFLYFVFDMAHFSGSKAN
What is the function of this protein?
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.  It prevents sialic acids from being recycled and returning to the cell surface.  Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity).
What are the official names of this protein?
N-acetylneuraminate lyase B, NALase B, N-acetylneuraminate pyruvate-lyase B, N-acetylneuraminic acid aldolase B, Sialate lyase B, Sialate-pyruvate lyase B, Sialic acid aldolase B, Sialic acid lyase B.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRR_STRSY
Sequence: MKTKEIVDDMTMKRAITRITYEIIERNKNLDNIVLAGIKTRGVFIAKRIQERLKQLEGIDVPLGELDTKPFRDDMKVEDDTTNMTANVNDRDVILVDDVLYTGRTIRAAIDNIVSLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSRSEEIIVHMAEIDGQDAVLLVEGA
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: GCH4_HAHCH
Sequence: MQIVRALPDIAKTRTEFETYTLQWVGMEDIAVPLTLNIGGGKQQSLPAKANVYVSLDDAAEKGIHMSRLHAILNQLASQVCDKEGLDLLLRNMVASQGKISRSAKVELVFDLLLPKPSLLSNETGFQTYRIEIGGQCLSEKYDYSLKITVPYSSTCPCSAALSRQLFSDAIDNEFSTSRIDKQELLSWALTSTVATPHSQRSYAYLNLLLGNHGWPSLSSFIMQIEEAIGTPVQTMVKRTDEQEFARLNADNLMFCEDAARNVKTLLEQSSWIEDYWFKVEHQESLHAHNAVVIDQKYSKGAML
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: PTPA1_YEAST
Sequence: MSLDRVDWPHATFSTPVKRIFDTQTTLDFQSSLAIHRIKYHLHKYTTLISHCSDPDPHATASSIAMVNGLMGVLDKLAHLIDETPPLPGPRRYGNLACREWHHKLDERLPQWLQEMLPSEYHEVVPELQYYLGNSFGSSTRLDYGTGHELSFMATVAALDMLGMFPHMRGADVFLLFNKYYTIMRRLILTYTLEPAGSHGVWGLDDHFHLVYILGSSQWQLLDAQAPLQPREILDKSLVREYKDTNFYCQGINFINEVKMGPFEEHSPILYDIAVTVPRWSKVCKGLLKMYSVEVLKKFPVVQHFWFGTGFFPWVNIQNGTDLPVFEEKEEESIEQANAGSPGREQTSTRFPTSTSMPPPGVPPSGNNINYLLSHQNQSHRNQTSFSRDRLRR
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase.  Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.  Involved in the regulation of cell cycle progression, mitotic spindle formation, bud morphogenesis and DNA repair.
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A activator 1, Peptidyl-prolyl cis-trans isomerase PTPA-1, PPIase PTPA-1, Rotamase PTPA-1, Phosphotyrosyl phosphatase activator 1.
What is the protein family that this protein belongs to?
Belongs to the PTPA-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS9_BORRA
Sequence: MAKSDVKGVNLGMGTGRRKSSVARVYIREGKGDIKINHKNFDVYMQLEKLKTIALSPLALTHTLGKYDIYINVYGGGISGQAGAIRHGIARALFDLDEEYKMVLKSNEFLTRDSRKVERKKFGKKKARKSFQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: SNAAA_LYCMC
Sequence: MNFLIFIAVASSLALGALCKKEGYPYDGNNCRYICFRNQYCDDLCKKLKGESGYCYGWNQSCYCYGLPDTEKTKPDKRCHSKG
What is the function of this protein?
Binds voltage-independently at site-3 of voltage-gated sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Neurotoxin LmNaTx10.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATN1_MARPO
Sequence: MMGANSTEWHGQSVEQVTELLGTDVERGLKESVVGQLQKQFGPNELKGQRGVNPWKVLLAQFTNGLTVILLIATVVSFAVQDHAEGGVLAFVIIFNASVGFVQEYRAEKTMDALRRMASPTAKVIRDGGLDRISSPGVVPGDIIVFEVGDVVPADCRLIEVLNLEVDEAMLTGESLPVAKTVEAIKGENATVGDRLNMVYSSTILTKGRGKGIAVATGMSTEIGKITKSISETGQSSTPMQKRLNRMAYILFGISLVLAVIVFAVNKFEFNTDIIIYAVSLGIAVIPEGLIAVITIVMALGVRRMASQQALVRKLVALESLQAVTNICSDKTGTLTQGKMTVTTLWLPGMEDQYSISGNGWETSGEISVREQPIDAQECLSDLRFRLLVECSALCNTANIVEASEGKVWGDPTEIALQVLAYKLQMGKPSFRSRKEPITEYPFSSAEKRMSMLYRDVERDAFEIYTKGAENVLAICDRLLEKGEEVEISSRDEFMQSVSAQIQIMAKQGLRVLVVAYRTVSEKEMAKSVSKWERVDVERNMTFLGLVGIRDTPRPESRIAVDQCYEAGIIVHMLTGDHHDTALAIAREVGIIRPAPNSADESVVPMSNPVMTAAEFDALSEEQIDDLNELPLVIARCTPATKVRMIEALHRRKKFAAMTGDGVNDAPSLKKADVGIAMGAGSDVAKQSSEIVLTDNNFATIVMAVSEGRRIFSNIRKFILHLVSTNVGEVIVLIIGLAFKDRNGVSVFPLAPVQILFMNMVTSTPPAMALGVEAASKDTMKVPPHTKGLFGKEVLADMMVYGIIMGSLILVDWVLVIYAFGDSQLGLECNSDRMLNECNTVFRARSTIMVALIWMLLLHAYNCRHPRASLFTAEGGGASKLFSNRLLVWSVLLGSLMPIPTVYIPTLNTKIFKQETISWEWSIVVVSVVAFFFLSELYKLIKRNVMTSRVI
What is the function of this protein?
Catalyzes the hydrolysis of ATP coupled with the export of sodium and potassium from the cell (PubMed:19757095).  Appears to export potassium more efficiently than sodium (PubMed:19757095).  May transport other cations such as lithium (By similarity).  Sodium/potassium efflux ATPases are involved in salt tolerance and maintaining the membrane potential across the plasma membrane in high salinity (Na+) or alkaline (K+) environments (PubMed:19757095).
What are the official names of this protein?
Sodium/potassium exporting P-type ATPase 1, MpENA1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.
Protein: YPDJ_ECOLI
Sequence: MGYDSRLDHLAATSWYPFFNNVTTRGEIIEPYSLTLDEACQFLKIS
What is the function of this protein?
May be involved in H(2) production during fermentative growth.
What are the official names of this protein?
Protein YpdJ.
Protein: Y580_MYCSS
Sequence: MSALAVALARQSESHADCPLFNDPYAQVFIDAALSRGCQLPSDETSERINGIANYASSRTKWFDEYFIAAGAHGLEQMVIVAAGLDARAWRLPWVAGTTLFEIDHPGVLKFKNEALHEHGESPSVSRYVPVPADLSDGWSERLRDAGFDVSEPTAWAVEGLLPYVADGPHLLFDRIHEISPAGSRLAVEAVGTGVADWLSTQGWQVTMIGAQELMTRYGRCGDHSDTDAGMDTVFVNATRTR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Mmcs_0580.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: FTSB_SERP5
Sequence: MGKLTLLLLALLGWLQYSLWLGKNGVHDYVRVNDDVAVQQGSNAKLKARNDQLFAEIDDLNGGQEAIEERARNELSMIKPGETFYRLVPDQSRRNAASSSQNNLQK
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: ATPF_ECOLC
Sequence: MNLNATILGQAIAFVLFVLFCMKYVWPPLMAAIEKRQKEIADGLASAERAHKDLDLAKASATDQLKKAKAEAQVIIEQANKRRSQILDEAKAEAEQERTKIVAQAQAEIEAERKRAREELRKQVAILAVAGAEKIIERSVDEAANSDIVDKLVAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: IL2RG_CANLF
Sequence: MLKPPLPLRSLLFLQLSLLGVGLNSTVPMPNGNEDITPDFFLTATPSETLSVSSLPLPEVQCFVFNVEYMNCTWNSSSEPRPTNLTLHYWYKNSNDDKVQECGHYLFSREVTAGCWLQKEEIHLYETFVVQLRDPREPRRQSTQKLKLQNLVIPWAPENLTLHNLSESQLELSWSNRHLDHCLEHVVQYRSDWDRSWTEQSVDHRNSFSLPSVDGQKFYTFRVRSRYNPLCGSAQRWSEWSHPIHWGSNTSKENPLFASEAVLIPLGSMGLIISLICVYYWLERSIPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSEWLCHVSEIPPKGGAPGEGPGGSPCSQHSPYWAPPCYTLKPETGALIP
What is the function of this protein?
Common subunit for the receptors for a variety of interleukins.  Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).
What are the official names of this protein?
Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, IL-2RG, gammaC, p64.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 5 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell surface.
Protein: DHE3_CHAAC
Sequence: ADAADKPDDPNFFRMVEGFFDRGASIVEDKLVEDLRTKETPEQKKGRVAGILRIIKPCNHVLSLSFPIKRDNGEWEVIEGYRAQHSQHRTPCKGGIRYSMDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVRINTKNYSDNELEKITRRFTIELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYANTIAHTDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFMNEASYMSMVGLTPGVQDKTFVIQGFGNVGLHSMRYLHRFGAKCVGIGEIDGAIYNADGIDPKALEEYKLQNGTIVGFPGAKPYEGSILEADCDILIPAAGEKQLTRNNARRIKAKIIAEGANGPTTPDADKIFLENNVMVIPDMYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKQGGPIPVVPTADFQARVAGASEKDIVHSGLAYTMERSARQIMRTASKHNLGLDIRTAAYVNAIEKVFKVYNEAGLTFT
What is the function of this protein?
Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate.  Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity).
What are the official names of this protein?
Glutamate dehydrogenase, mitochondrial, GDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RS19_CHLFF
Sequence: MGRSLRKGPFVDHSLIKKVRAMNLLEKKAPIKTWSRRSMITPEMIGHTFEVHNGKKFLTVFVSETMVGHKLGEFSPTRMFKSHPVKKG
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: KUP_THEVB
Sequence: MTKANAGHPPSRLLMLGALGVVYGDLGTSPLYAFEETFNPLHVLAVTPANIYGILSLILWGLVLIPTLKYATFALRADNDGEGGIFPLMALVLSRIRLSSHWRRRVIIFGLVGAAMFYGDSTITPAISVLSAIEGLEVLSPQLGSWTVPLTVVILVGLFWFQHRGTTQVGQVFGPIMFLWFMTLGLLGTIHIFEQPTILNALNPWWGVQLFYSQPAQVFFLLGVVILALTGAEAMYADMGHFGIQPIRLAWYRLVFPALALNYLGQGAFILKHPTATHHLFFQLAPEWSVLPLVILSTLATVIASQAVISGAFSMTAAAIKLGYLPRLRIDVTDDYHRGQIYIPVINWLLLVTVLLLVMTFRKSSELAGAYGLAVNLTMVVTTLCLILVARHLWRWSIVQISLVWVSILVIEIAFLIGNALKIPYGGWYPLAFGGVVYMLLGTWRQGQVLLRQQLLQANARFSLKELLSQGVARVPGIAVFFSPLPDMIPLSFIQNLQHNHVLHQQTIFIHLATANLPHVPLSEQLTYRVTDVGIYEIILTSGFRDRPDLRLALETCQQALNLPLNGQPMSFFLGRRTIIPTHARGMTYWQKVVFAWLYRNAEDATSYFRLPSEQVVELGIQVEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL28_SYNS3
Sequence: MSRVCQLTGTRANNGMAVSHSHIRTKKLQQANLQQRRLWWAEGKRWINLRITTRALKTIQKKGLGAYARSLGINLAKL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: ATPG_ACTSZ
Sequence: MASGKEIKTKIASVQSTQKITKAMEMVATSKMRKTQDRMAASRPYSETIRNVISHVSKASIGYKHPFLMEREVKTVGMLVVSTDRGMCGGLNINLFKAVLNEIKKWKEQGVTVEVGVIGAKGIAFFRSLGFKIRAQHSGIGDNPSVEELLGIANDMFDAYKEDKIDALYLAHNQFINTMSQKPSVAQLVPLPELDTDNLDERQQVWDYLYEPEPKVLLDNLLTRYLESQVYQSVVDNLASEQAARMVAMKAATDNAGNLINDLQLVYNKARQASITNELNEIVAGAAAI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: COAA_STRZP
Sequence: MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIKNGQDVDIPVYSHEVYDIVPEEKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSLAQNDPDSYYYRFTQMPIGEVEAFAHQVWTSINLTNLQNYIEPTRNRAEVILHKSKNHEIDEIYLKK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZAPD_SALA4
Sequence: MHTQVLFEHPLNEKMRTWLRIEFLIQQLSINLPIADHAGALHFFRNISDLLDVFERGEVRTELLKELERQQRKLQAWVEVPGVDQDRIEALRQQLKSAGSVLISAPRIGQQLREDRLIALVRQRLSIPGGCCSFDLPTLHIWLHLQQAQRDAQIESWLASLNPLTQALTLVLDLIRNSAPFRKQTSLNGFYQDNGDDADLLRLMLMLDSQLYPQISGHKSRFAIRFMPLDSENGLVPERLDFELACC
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: THIC_LEPIC
Sequence: MEPVQKLQIPYKSIRLSDGTEYQSYHTEGALSGKQPADYKNGIPAFRKEWIQKRFNHSNHSQMYFAKKGIITEEMRYAAFRENMEPEFVRSEIACGRAILPSNRNHPELEPMVIGKNFLVKINANIGNSTFSSSIEEEVEKLHWAIKWGADTVMDLSTGKNIHETREWILRNSPVPIGTVPIYQALEKVKGKTENLNIQIFLETLEEQAEQGVDYFTIHAGVLLRYIPLTTNRITGIVSRGGSILAKWCQAHHKENFLYTHFDEILKVMKKYGVSISLGDGLRPGSIADANDKAQFSELETLGELTQLAWKEDIQVMIEGPGHVPMNLIKENVDLQTKICQEAPFYTLGPIVTDIAPGYDHITSAIGAAMIGWYGTAMLCYVTPKEHLGLPNKEDVKQGVIAYKIAAHAADLAKGHPGAIDRDNLLSKARFEFRWEDQFSLSLDPETAKTFHDEMLPQDRMKTAHFCSMCGPHFCSMNLTQELRKFAQEKEIQES
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: HEMA_I56A1
Sequence: MLSIVILFLLIAENSSQNYTGNPVICMGHHAVANGTMVKTLADDQVEVVTAQELVESQNLPELCPSPLRLVDGQTCDIINGALGSPGCDHLNGAEWDVFIERPNAVDTCYPFDVPEYQSLRSILANNGKFEFIAEEFQWNTVKQNGKSGACKRANVDDFFNRLNWLVKSDGNAYPLQNLTKINNGDYARLYIWGVHHPSTSTEQTNLYKNNPGRVTVSTKTSQTSVVPDIGSRPLVRGQSGRVSFYWTIVEPGDLIVFNTIGNLIAPRGHYKLNNQKKSTILNTAIPIGSCVSKCHTDKGSLSTTKPFQNISRIAVGDCPRYVKQGSLKLATGMRNIPEKASRGLFGAIAGFIENGWQGLIDGWYGFRHQNAEGTGTAADLKSTQAAIDQINGKLNRLIEKTNDKYHQIEKEFEQVEGRIQDLENYVEDTKIDLWSYNAELLVALENQHTIDVTDSEMNKLFERVRRQLRENAEDKGNGCFEIFHKCDNNCIESIRNGTYDHDIYRDEAINNRFQIQGVKLTQGYKDIILWISFSISCFLLVALLLAFILWACQNGNIRCQICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: TY24_PITAZ
Sequence: FPPWM
What are the official names of this protein?
Tryptophyllin-T2-4, Pha-T2-4, Tryptophyllin-8.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Tryptophillin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UBP33_DANRE
Sequence: MSGVSSNDCPHLECVGEITKEELIQKSHGQCQDCKVGGPNLWACLENGCSYVGCGESHADHSTVHSQETRHNLTVNLTTLRVWCYACTKEVFLERKLGPHKQLPNAAKAVSPVQTPCQDLNTPGSPTSLRVPSAGTCDDLDMETEEEDELRTRGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLECGGLVKTDKKPALCKSYQKLITDLWHKNRNAYVVPTNLFQGIKAVNPMFRGYSQQDSQEFLRCLMDQLHEELKELIPEPEDPNQAVAMDDSPDEDNHSQSDDFQSCESCGSSDRADNEGPRVPEDINEAEMLMPEQNQNNRDWQKEKNLINNLYRAGSHGDLDKDVDTTSDSRPIISSQGAIKAQGRTSDSEIQVSSTVRPQSPTGNEGITSRLSSSPPKSSAWPNLSSTHKKVPMFTPTKTKRQRKYHSIISEVFDGTIVSSVQCLTCDRVSVTLENFQDISLPIPGKEDLAKLHSSSHQTALVKAGSCGEAYAPQGWIAFVMEYIKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQSLPEILCIHLKRFRHELMFSTKIGTHVSFPLEGLEMQPFLAKDSSALTTTYDLLSVICHHGTASSGHYIAYCRNELNQLWYEFDDQSVTEVSESCVQNAEAYVLFYKKSNDETQKERRKVTSLFNMMEPSLLQFYVSRQWLNKFKTFAEPGPISNHDFLCAHGGIPPNKAAYIDDLVLMIPQNVWDHLYSRYGGGPAVNHLYVCHTCQNEIEKLEKRRKNELDMFVRLNKAFQEEESPVVIYCISMQWFREWESFVKGKDIDPPGPIDNSKIAVNKNGHITLKPGADSGQISEETWNFLHNIHGGGPVVTVRPSVSHQESETSQSEEKIEVETRTV
What is the function of this protein?
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling.  Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate.  Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling.  Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1.  Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2).  Deubiquitinates dio2, thereby regulating thyroid hormone regulation.  Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 33, Deubiquitinating enzyme 33, Ubiquitin thioesterase 33, Ubiquitin-specific-processing protease 33.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP20/USP33 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (By similarity).
Protein: RL17_ELUMP
Sequence: MIKNTGHRKLGKTGSHRRAMLNNMATSIILHEQVETTVAKAKEVRRVVDNLVTLAKNGQNLQVKDTLKDKVAYKKLFEVLASRYEKRPGGFTRIYRAGKRPGDNAEVAIIKLVD
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RL18_DEHM1
Sequence: MAKVNAREARIVRHERLRKKVSGTEARPRLCVFRSIENIYTQVINDNCGSTLVQASTKDAELKAELDGKTKTEQAVVIGNLIAKRSLEAGISEVVFDRGGYKYHGRVKALAEAARSGGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: GCH1L_METJA
Sequence: MKAKEIIEFIETFAPKDLAIEGDNIGLQVGDNLDKEIKKLGIALDPSLSVIKKAEKEGVDFLFTHHPLLKDPIRNFTGVIYKKLKILMENDIILYSAHTNLDICKNGLNDALAELYNLENPKPLYDNGLGRVGIFKGSFEEFLEITKKYIHKNPIVVKSKEVDDNFKLAVLSGYGLSQSSIKYVAEKADVYLSGDLTHHSKILAEELGLVVVDATHYSTEVFGLKKFKEFLSSNLDLEIISLDF
What is the function of this protein?
DNA-binding protein exhibiting the ability to bind to both single-stranded and double-stranded DNA.
What are the official names of this protein?
GTP cyclohydrolase 1 type 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I type 2/NIF3 family.