PharMolix/UniProtQA huggingface dataset:
Protein: RF1_PARD8
Sequence: MAENSLLGKLDGLVSRFEEVGTLITDPAVIADMKRFVKLNKEYRDLEKIVGARSEYVKVLNGIEEAKALLESEQDPEMREMAREELDTCNERIPALEEEIKLLLVPADPQDDKNAIVEIRGGTGGDEAALFAGDLYRMYVKYCELKGWKISVSSFSEGSSGGFKEIIFTVSGEKVYGTLKYESGVHRVQRVPATETQGRVHTSAATVAVLPEADEFDVEINEGEIKWDTFRSGGAGGQNVNKVESGVRLRYVWKNPITGVSEEILIECTETRDQPKNKERALTRLRSFIYDKEHQKYLDDIASKRKTMVSTGDRSAKIRTYNYPQGRITDHRINYTIYNLSAFMDGEIQDCLDHLIVAENAERLKESEL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_STAHJ
Sequence: MTILSEIVDYKEQLLKDGYYHDKLQNLKGVKHKNKSRLTDALIKNDNLTLIAEIKSKSPSVKAFQQTNIIKQVSDYERYGANAISVLTDERYFGGSFERLQQISETTQLPVLCKDFIIDPLQIDVAQKAGASIILLIVNILTDEKLRQLYQYASSKGLEVLVEVHDGIELQRAYQLNPQIIGVNNRDLKSFNTDVKHTNQILKCKKENYLYISESGIHSQQEVKQIVKSGIDGLLVGGALMNCNELEHFIPSLKLKKVKQ
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: SSDH_HUMAN
Sequence: MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
What is the function of this protein?
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
What are the official names of this protein?
Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: S22AH_RAT
Sequence: MASDPIFTLAPPLHCHYGALPPNASGWEQPPNSSGVSVAGAALAASAASRVVTSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGIMTLRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQELENTCPLPTTSTFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNDAAITTFSVLGLFSSQASAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSCPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPNRCDHVPLLATPNPAL
What is the function of this protein?
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport.  Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis.  Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
What are the official names of this protein?
Solute carrier family 22 member 17, 24p3 receptor, 24p3R, Brain-type organic cation transporter, Lipocalin-2 receptor.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized.
Protein: GATA_COXBN
Sequence: MHQKTIAELKQDLRDKTISSVELTQHFLDRIKTINPTLNSFISITEEYALTQAKAADARLAKGEATSLTGIPIAQKDIFCTKDIKTSCGSKMLDNFIAPYDATVVEQLNKAGAILIGKTNMDEFAMGSSNENSYFGAVKNPWDLERVPGGSSGGSAAAVAARLVPGATGTDTGGSIRQPAALCGITGLKPTYGRVSRYGMIAFASSLDQAGPMAQTAEDAALLLNALAGHDAKDSTSINKNVPDYTATLTTSLEGLKVGLPKEYFGEGLNSSIAESIETVKKTLEKMGATFIEIQLPHTDFAAPAYYVLAPAECSSNLARYDGVRYGYRCDKPVDLDDLYKRSRTEGFGSEVKRRIMIGTYVLSAGYYDAYYLKAQKIRRLIRDDFMKAFETVDVILTPATPTPAFKLNEKIADPVAMYLSDVYTIAVNLAGLPAIAFPAGFMDQLPIGAQLIGNYFEEARLLNITHRYQQETDWHKQSPKLR
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: THIG_TRIEI
Sequence: MQTVEKLTTETLEKPLIIAGKKFTSRLMTGTGKYPTIETMQQSIEASKCEIITVAVRRVQTQAPGHKGLAEAIDWQKVWMLPNTAGCQTAEDAVRVARLGREMAKLLGQEDNNFVKLEVIPDSKYLLPDPIGTLQAAEQLIKEGFAVLPYINADPLLAKRLEEAGCSTVMPLGSPIGSGQGIQNAANISIIIDNSTVPVVIDAGIGTPSEATQAMEMGADALLINSAIALAKNPPIMAKAMGMATESGRLAYLAGRIPKKSYATPSSPVTGKINTTTSE
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGI_CAMJJ
Sequence: MRVLTIFLLFMTSIFAVQIKDVANTVGVRDNQLIGYGLVVGLNGSGDGTSSKFTLQSISNLLQGMNIKVDPNDIKSKNTAAVMVTAKLPAFAKSGDKLDITVSSMGDAKSLQGGTLLLTALRGIDGEIYAIAQGSISTGGLTPRPGGAGSHSTAATVMGGANVEREIPQNFSQNSDLTLSLKVADFKTANDIERVLNTVFGEEVAKAIDSRTVKLKKPEDLSNVDFMARVLEQDIAYKPQSKVIIDERTGTVIAGVDVEVEPVLITHKDITIKIDPNNNAVANQNEIDMKDGGFVDPSSNTLRINNAKSTVANIARMLNKLGATPNDIIAIMENLKRAGAINADLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: ADH2_DROHY
Sequence: MAIANKNIIFVAGLGGIGLDTSREIVKSGPKNLVILDRIDNPAAIAELKAINPKVTITFYPYDVTVSVAESTKLLKVIFDKLKTVDLLINGAGILDDYQIERTIAVNFAGTVNTTTAIMAFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLAKLAPITGVTAYSINPGITKTTLVHKFNSWLDVEPRVAELLLEHPTQTTLQCAQNFVKAIEANKNGAIWKLDLGRLDAIEWTKHWDSGI
What are the official names of this protein?
Alcohol dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: COAX_SYNAS
Sequence: MLLVIDVGNTNTVLGVFDGEELVHDWRIRTVIENTVDEYGMLMYNLYKTSKISSKAIQHIIISCVVPPMLNILEPVCEKYFQVKPLIVGPGIKTGMPIFYDNPKEVGADRIVNAVAVFEKYKREAIVVDFGTATTFDYVSPRGEYMGGCIAPGIVISSEALFTRASKLPRVEFSTPKLIIAKDTVSSMQAGIIYGYAGLVDGIVARMKEEIGSNPLVIATGGLAKVVKPETRSIEMIDDMLTLEGLRLIYKRNS
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_CAMJR
Sequence: MVSMRDLLECGVHFGHQTRRWNPKMKKFIFGERKGIYVIDLQKTLRYFRYTYNIVRDAAAEGKTILFVGTKKQAGGAIKEYAEKCGMPYVNHRWLGGMMTNFGTIRQSIRKLEVIEKMEEDGSIKLLTKKEALMLTRKKEKLLAYLGGIRYMKTQPDMIFVIDTVKEKIAVQEANRLRIPVVAPLDTNCDPDLVTYPIPGNDDAIRSVQLFCQEMAEAINEGKALREQDGEALANEEKEITDEEKKEVLDEAMSEEDFGEEQE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: MATK_OENPA
Sequence: MEEFPGYFELDRSRQHDFLYPLIFRESIYALAHDHGLNRNRSTLFENEVDYDKKYSLIIVKRLITRMYQRNHLIISANGSVQNPFLGHNKNLYSKILSEGFAVIVEIPFSLRVLSSFERKEKDIAKSPTLRSIHSIFPFLEDQFSHLDYLSHVLIPYPIHLEIAVQTLRYWVKDASSLHLLRIFLHEYWNSFSTPKKHITLFLKGNSRFFLFLYNSYVCEYESIFLFIRNQSSHFQSTSSGVFFERILFYVKIDHLVEVFVGTDFLDIRSFFKDPNMHYVRYQGKSILASKDTPLLMNKWKYYLVNLWQYHFSVWSQPGRININQLGKYSLDFLGYFSNVQLKSSVVRNQTLENSFLINNAMKKLETTVPILPLIGSLSRAKFCNALGHPISKPTRTDSSDSDIIDRFVRICRNLSHYHSGSSKKKSLYRIKYILRLSCVKTLARKHKSSVRAFLKRLGSELGDEFLTEEGVVLAVIFPKASGRLYRGRIWYLDIPCINDWVGDAEGSIFTK
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NQRB_PASMU
Sequence: MGLKHFIEKIEPAFLPGGKYEKWYALFEATATFLYTPGTVTHKASHVRDALDSKRMMVLVWLSLFPAMFYGMYNVGAQAILATDALGTLQQAISGHWQYALSHALGADLTLSAGWASKMLLGATYFLPIYLTIFLVGGFWEVLFAMVRKHEINEGFFVTSILLALIVPPTLPLWQAALATTFGVVVAKEIFGGVGKNFMNPALAARAFLFFAYPAQISGDTVWVAADGFSGATALSQWAVGGEAGLKHVVTGQPITWMDAFIGNIPGSIGEVSTLALIIGAAIIVFARIASWRIIAGVMIGMIATSALFNLIGSSTNPLFAMPWYWHFVLGGFALGMFFMATDPVSAAFTNKGKWWYGILIGAMAVLIRVVNPAYPEGMMLAILFANLFAPVFDYLVVQANIKRRRARNV
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit B, Na(+)-NQR subunit B, Na(+)-translocating NQR subunit B, NQR complex subunit B, NQR-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TATD_ERWT9
Sequence: MFDIGVNLTSTQFAKDRDKVIKRAREAGVSGMLITGTNALESQQALSLARQHPDYCWSTAGVHPHHASEWSGETAATLRRLAESPQMVAIGECGLDFNRNFSDPEQQAYAFNAQLALAAELSLPVFLHCREAHERFISILKPWLPKLKAAVLHCFTGTRPELESCLAEGLFIGITGWICDERRGQELRELMPLIPADRLLLETDAPWLLPRDMRPRPPSRRNEPCFLPHIVQQVALLRGDDAGELAAQTALNARRLFNL
What is the function of this protein?
3'-5' exonuclease that prefers single-stranded DNA and RNA.  May play a role in the H(2)O(2)-induced DNA damage repair.
What are the official names of this protein?
3'-5' ssDNA/RNA exonuclease TatD, DNase TatD.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STDH2_CAEEL
Sequence: MDIQWFATGVGAAVVLYIFYHFIRIILNILVPYAFCQPIDLKKKAGASWAVVTGATDGIGKSYSFELARRGFNVYIVSRTQSKLEQTKKDILEKQPDIEVRFATYDFTNPSVTDYEKLLSKLNEVSVGILINNVGMFFDYPEMLHKINGGIDSIANVIIINTLPATLLSAGILPQMVSRKAGIIVNIGSFAGVVKLAEWSIYSATKKYVEWLTGCLRKEYSHHGIIFQAITPAMVATKMAGNPNTSFFCPDSDTFARSALNTIGHASETTGYIAHQIQCEILKLLPDFVIDRSIKKGNAEFREKALAKSENKPLA
What are the official names of this protein?
Putative steroid dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
Protein: PTR52_ARATH
Sequence: MDVESSSPSSHALIKKEKGGWRAIKYIIANESFEKLASMSLIGNLSVYLMTKYNLGGVFLVNVINIWFGSCNILTLAGAFVSDAYLGRFWTLLLGSIASFIGMGIFALTAALPSLRPDACIDPSNCSNQPAKWQLGVLFSGLGLLAIGAGGVRPCNIAFGADQFDTSTKKGKAHLETFFNWWYFSFTVALVIALTGVVYIQTNISWVIGFVIPTACLALSITTFVIGQHTYICAKAEGSVFADIVKVVTAACKKRKVKPGSDITFYIGPSNDGSPTTLVRDKHRLRFFDKASIVTNPNELNEDGNAKYKWRLCSVQQVKNLKCVTAILPVWVTGIACFILTDQQNIYGILQAMQMDKTFGPHNFQVPAGWMNLVSMITLAIWISLYECVIIPIVKQITGRKKRLTLKHRIEIVMGIICMIVAGFQEKKRRASALKNGSFVSPVSIVMLLPQFALAGLTEAFSAVALMEFLTVRMPEHMRAVAGAIFFLSSSIASYICTLLINVIDAVTRKEGKSWLGDKDLNKNRLENYFFIIAGIQVANLLYFRLFASRYATENKKGH
What are the official names of this protein?
Protein NRT1/ PTR FAMILY 2.8, AtNPF2.8.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MSRA_MYCGE
Sequence: MKEIYFGGGCFWGIEKYFQLIKGVKKTSVGYLNSRIRNPSYEQVCSGYTNAVEAVKVEYEEKEISLSELIEALFEVIDPTIRNRQGNDIGTQYRTGIYWTDSSDEKIINDKFLKLQKNYSKPIVTENKKVENYYLAEEYHQDYLKKNPNGYCHIKFD
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: NHAA_BRUO2
Sequence: MNHSPQSARPVSIMRRFLDSEAAGGITLMAAAALALIVANSPFAQTYFDALHLYIGPLSLAHWINDALMAIFFLLVGLEIKREMLDGQLASWPNRMLPGIAAAGGVILPAIIFAVLNHDNPAKLRGWAVPSATDIAFALGVLSLLGSRAPSSLKVFLATLAILDDLAAVVIIAIFYTAEISMPYLGAAFITAAVLFVMNRMGVVKLLPYLISAVILWFFVFNSGVHATVAGVVAALMIPLKPAPGRPDDMTSPLHKLEHALAKPVAFIVVPIFGFANAGISFKGLEASVLGDTLTLGILLGLFLGKQFGVFGAAWLAIKTGLAEKPMGASWVQLYGVAILCGIGFTMSIFIGLLSFPSDLMQTETKIGVLSGSALSAICGYLLLRAAARPKRG
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WTM2_YEAST
Sequence: MAKSKSSQGASGARRKPAPSLYQHISSFKPQFSTRVDDVLHFSKTLTWRSEIIPDKSKGTLTTSLLYSQGSDIYEIDTTLPLKTFYDDDDDDDNDDDDEEGNGKTKSAATPNPEYGDAFQDVEGKPLRPKWIYQGETVAKMQYLESSDDSTAIAMSKNGSLAWFRDEIKVPVHIVQEMMGPATRYSSIHSLTRPGSLAVSDFDVSTNMDTVVKSQSNGYEEDSILKIIDNSDRPGDILRTVHVPGTNVAHSVRFFNNHLFASCSDDNILRFWDTRTADKPLWTLSEPKNGRLTSFDSSQVTENLFVTGFSTGVIKLWDARAVQLATTDLTHRQNGEEPIQNEIAKLFHSGGDSVVDILFSQTSATEFVTVGGTGNVYHWDMEYSFSRNDDDNEDEVRVAAPEELQGQCLKFFHTGGTRRSSNQFGKRNTVALHPVINDFVGTVDSDSLVTAYKPFLASDFIGRGYDD
What is the function of this protein?
Transcriptional modulator with roles in meiotic regulation and silencing.
What are the official names of this protein?
Transcriptional modulator WTM2.
Protein: GLMU_BORA1
Sequence: MLNVVILAAGLGKRMQSDLPKVLHTLAGQPMLGHVLESARDLQPGRIVVVVGHGAERVEAAYAGQAGLSFALQRPQHGTGHAVQQAVPQLMEGDGAEDATLVLYGDVPLVQPETLRRLMAARGQGVAVLTEVLPDATGYGRIVRDAQGQVTRIVEHKDANEQERAIKEVNTGILVAPTAKLKDWLTRIDNNNAQGEYYLTDIIALAVADGVTVSAAQPAASWETLGVNSRAQQAELERRWQAELARRQLEAGVTLADPARFDQRGTLECGRDVYIDVGCVFEGRVKLGDGVRVGPHCVLRDVEVGAGTQIEAYSHLQQARVGDEARVGPYARLRPGADLGNQAHVGNFVEIKNAVLGEASKANHLAYIGDADIGARVNVGAGTITCNYDGVNKHRTIIEDDAFIGSDTQLVAPVRVGRGATLAAGTTLTRDAPADSLTLSRIRQSTVPGWKRPVKKS
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y167_ABVP
Sequence: MSHKQGGHKTKGLVFPSNWTGKWLYRAIINTPKWQLNSVLNSYKFNQWIAFESMQLNGLQLSPRVSPETNFIRSVEVGIAVSEAGKQYESVPHKVPLEDKVRLLKEELEVPIIGDMVRSMTQAVLPGPMPVMYPNTAEVETPVEIKGKEIPIEFKEEGKEIPVMAVG
What are the official names of this protein?
Uncharacterized protein ORF167.
Protein: ABCB6_DICDI
Sequence: MGRFGAVSYRQVKQSEADTIEIDSLKNGDIEKYNEENDKISRIPLAQLSINKINGIKSSVIEELSLKRPSYFMATKMIKSLLPYYWKKNPFKFRIILCVSIIFFSKLINLSVPLIFKNIINTLPEKVEWHLLILYGVLFLIQKSIWDIRDLLFQDVNDSATKQINLETFDHLHRLSLSYHLNKRTGSLIKIVERGTSSVVQLLSLLLFNIFPTLVELFTVSTFLLFSYGAEFAFINLTSCVVYIAFTLYVTERRTKHRRLANKKENEASDIKVDSLMNFETIKYFTAESYERKRYDFALMDFFQTNKKSKVSYFLLNFGQSSIIVIGTTLGLGLATWRASQNGFTLGDVIAINTFIAQMFSPLSWLGSSYRMILTAFTDMENLFELLDTQPEVSDSPNAKELNFNDTNNPSKTILPSIEFRNISFTYPNKNKEQQQSSPKILDNISFTVPAGKSIALVGSTGGGKSTIFRLLCRFYDVDQGEILINGENIKDVTQTSLRSIIGVVPQETVLFNDTVAYNIGFGNREANDDQLIDASRRAQILSFIESSPDGFRTVVGERGLRLSGGEKQRVSIARALLKDPPILILDEASSSLDTFTERKIQQAINEVSKGRTTLVIAHRLSTIIHCDEILVLKGGHIVERGSHSYLLDFNGDYAHLWNQQQLSASDLQYTPNQDTFE
What are the official names of this protein?
ABC transporter B family member 6, ABC transporter ABCB.6.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: VSGP_EBOZ5
Sequence: MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKTSLEKFAVKSCLSQLYQTEPKTSVVRVRRELLPTQGPTQQLKTTKSWLQKIPLQWFKCTVKEGKLQCRI
What is the function of this protein?
Viroporin that permeabilizes mammalian cell plasma membranes.  It acts by altering permeation of ionic compounds and small molecules.  This activity may lead to viral enterotoxic activity.
What are the official names of this protein?
Pre-small/secreted glycoprotein, pre-sGP.
What is the protein family that this protein belongs to?
Belongs to the filoviruses glycoprotein family.
What are the subcellular locations of this protein?
[Small/secreted glycoprotein]: Secreted. SUBCELLULAR LOCATION: [Delta-peptide]: Secreted.
Protein: RHOA_MOUSE
Sequence: MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLIL
What is the function of this protein?
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:14697203).  Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle.  Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.  Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (By similarity).  Plays an essential role in cleavage furrow formation.  Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:11777936, PubMed:20974804).  Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.  The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex.  It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity.  In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).  Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis.  Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (By similarity).  May be an activator of PLCE1 (PubMed:9635436).  In neurons, involved in the inhibition of the initial spine growth.  Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity).  Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (PubMed:14697203).
What are the official names of this protein?
Transforming protein RhoA.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex. Midbody. Cell projection, lamellipodium. Cell projection, dendrite. Nucleus. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (PubMed:11777936). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner (By similarity).
Protein: ACSA_HUMAN
Sequence: MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
What is the function of this protein?
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429).  Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429).  Can also utilize propionate with a much lower affinity (By similarity).
What are the official names of this protein?
Acetyl-coenzyme A synthetase, cytoplasmic, Acetate--CoA ligase, Acetyl-CoA synthetase, ACS, AceCS, Acetyl-CoA synthetase 1, AceCS1, Acyl-CoA synthetase short-chain family member 2, Acyl-activating enzyme, Propionate--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TYSY_BARQU
Sequence: MKTYLDLLSHVLNKGIDRTDRTGVGTRSVFGYQMRFDLQIGFPLLTTKKLHLRSIIYELLWFLRGDTNVAWLKEHGVSIWDEWADEKGNLGPIYGYQWRSWPASDGRYIDQISRLLTMIKKTPDSRRLIVSAWNPALIEEMALPPCHCFFQFYVADDKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVSGLKAGDFIHTLGDAHLYSNHFEQARYQLSRIPNALPSMLINPSVTDLFSFKFEDFELLNYEAQPHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.