PharMolix/UniProtQA huggingface dataset:
Protein: LEUC_STAAM
Sequence: MGQTLFDKVWNRHVLYGKLGEPQLLYIDLHLIHEVTSPQAFEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDEIANKQITTLQKNAIDFGVHIFDMGSDEQGIVHMVGPETGLTQPGKTIVCGDSHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDINGTLPTGVYAKDIILHLIKTYGVDFGTGYALEFTGETIKNLSMDGRMTICNMAIEGGAKYGIIQPDDITFEYVKGRPFADNFAKSVDKWRELYSDDDAIFDRVIELDVSTLEPQVTWGTNPEMGVNFSEPFPEINDINDQRAYDYMGLEPGQKAEDIDLGYVFLGSCTNARLSDLIEASHIVKGNKVHPNITAIVVPGSRTVKKEAEKLGLDTIFKNAGFEWREPGCSMCLGMNPDQVPEGVHCASTSNRNFEGRQGKGARTHLVSPAMAAAAAIHGKFVDVRKVVV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: NUOH_HYPNA
Sequence: MSNAIESLGSLWGPLLVLGQIGLFTLVLLLSIAFLLLLDRKVWAGVMMRKGPNVVGPFGLLQSFADFGKFLLKEIVIPAGANKAVFILAPILTCTLAFVTWAAIPVAPGTATGTSWVIANLNVGVLYLFAISSLGVYGIIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVIVTVILLVGSMNLTTIVNNQDGGIQNWHVFSFQYFPLIVVMVPMFVIFFISALAETNRPPFDLPEAESELVAGYQVEYGSTPYLLFMLGEYLNIVLMCAMMTILFLGGWHGPISLGPELTANLPPLLLSLSGLAWFMGKVLFCFFLFALVKAIVPRYRYDQLMRLGWKIFLPTSLAAVIIVAGYVTFVGGLS
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: APOC1_MIRAN
Sequence: MRLFLSLPVLVVVLAMVLEGPAPTQAAPEISSTLGRIPEKLKEFGNTLEDKARAAVESIKQSDIPAKTRNWFSETFNKVKEQLKTAFS
What is the function of this protein?
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor.  Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL.  Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP).  Binds free fatty acids and reduces their intracellular esterification.  Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
What are the official names of this protein?
Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECA_PSEP1
Sequence: MDDNKKRALAAALGQIERQFGKGAVMRMGDHERQGIPAISTGSLGLDIALGIGGLPKGRIVEIYGPESSGKTTLTLSVIAEAQKNGATCAFVDAEHALDPEYAGKLGVNVDDLLVSQPDTGEQALEITDMLVRSNAVDVIIVDSVAALVPKAEIEGEMGDMHVGLQARLMSQALRKITGNIKNANCLVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRTGAVKEGDEVVGSETRVKIVKNKVSPPFRQAEFQILYGKGIYRNGEIIDLGVSQGLVEKSGAWYAYQGNKIGQGKANAAKYLAENPAIGAEIEKQIREKLLKAGAAAEAGKAAAAEADADDMADADAGY
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGA_BUCAI
Sequence: MKERNTELVQGFRHSVPYINAHRGKTFVIMLGGEAIKYGNFYSIINDIGLLHSLGIRLVVVYGACPQINTSLKEKNIKIIYHKSIRITDLASLEQVKQAAGKLQLDITARLSMSLTNTPLQGANISVVSGNFIISQPLGVDDGVDYCHSGRVRRIDKNAINCQLNNGAIVLIGPVAVSVTGESFNLTSEEIATQVSIELKAEKMIGFCGNQGVINDEGKIISELLSNDIKNIIKKLEKKGDYISSTVRFLKGSIKACKSGVNRSHLISYHKSGALLQELFSRDGIGTQMVMESAEKIRGASINDIGGILELIRPLEHKGILVRRSREQLEIEVDKFTIIEHDNLTIACAALYPFFKEKIGEMACLAVHPDYRNSSRGDALLKKIKMNAKDMHLKRIFVLTTQSIHWFQERGFILVDIEVLPESKKKMYNYQRGSKILMIDVI
What are the official names of this protein?
Amino-acid acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ArgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPM1_RABIT
Sequence: MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
What is the function of this protein?
Binds to actin filaments in muscle and non-muscle cells.  Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.  Smooth muscle contraction is regulated by interaction with caldesmon.  In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
What are the official names of this protein?
Tropomyosin alpha-1 chain, Alpha-tropomyosin, Tropomyosin-1.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Associates with F-actin stress fibers.
Protein: MPTX_MOUSE
Sequence: MEKLIVGILFLSVLSGSVAQTDMKGKAFIFPQESSTAYVSLIPKVRKSLQNFTLCMKAFTDLTRPYSIFSYNTRTKDNEILLFVENIGEYMFYVGNLVAIFKAPTNLPDPVRICVNWESVSGIAEFWLNGKPLGRKGLNKGYTVGGDAMIIIGQEQDSFGGNFDAKQSFVGEIWDVSLWDHVVPLEKVSDSCNNGNLINWQALNYEDNGYVVIKPKLWP
What are the official names of this protein?
Mucosal pentraxin.
What is the protein family that this protein belongs to?
Belongs to the pentraxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AT11B_HUMAN
Sequence: MWRWIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVAVPETALLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAEEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSINGMKYQEINGRLVPEGPTPDSSEGNLSYLSSLSHLNNLSHLTTSSSFRTSPENETELIKEHDLFFKAVSLCHTVQISNVQTDCTGDGPWQSNLAPSQLEYYASSPDEKALVEAAARIGIVFIGNSEETMEVKTLGKLERYKLLHILEFDSDRRRMSVIVQAPSGEKLLFAKGAESSILPKCIGGEIEKTRIHVDEFALKGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHVDPHVLQNKPTLYRDISKNRLLSIKTFLYWTILGFSHAFIFFFGSYLLIGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFVFSLFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDIIKKVFDRHLHPTSTEKAQLTETNAGIKCLDSMCCFPEGEAACASVGRMLERVIGRCSPTHISRSWSASDPFYTNDRSILTLSTMDSSTC
What is the function of this protein?
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401).  May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401).
What are the official names of this protein?
Phospholipid-transporting ATPase IF, ATPase IR, ATPase class VI type 11B, P4-ATPase flippase complex alpha subunit ATP11B.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
What are the subcellular locations of this protein?
Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Golgi apparatus, trans-Golgi network. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed:21914794).
Protein: ODO1_GEOSW
Sequence: MTKQTMNYAEPWSQFYGPNLGYVMEMYEQYLEDPDSVDPELKQLFKEWGAPTTEAERFDHSESAAKTYQTFRLPENPTIFSKLVAAVKLADKIRHYGHLAADINPLNTQNKDTRRIELSEFDLTEDDLKQIPVAFICPHAPAHVKNGLDAINHLRKIYTDKIAFEFSQVHNLEERNWLISQIESGAYYPSLTNEEKVALLRRLTEVEGFEKFLHRTFVGQKRFSIEGLDSMVPLLDELIRHSIEEEVKAVNIGMAHRGRLNVLAHVLGKPYEMIFAEFQHAESKDFMPSEGSVAITYGWTGDVKYHLGAARRLRNKNEHTMRITLANNPSHLEVVNPVVLGFTRAAQEDRSNAGVPSQDTDSAFAIMIHGDAAFPGQGIVAETLNLSRLQGYQTGGSIHIIANNMIGFTTESYDSRSTKYASDIAKGFEIPIVHVNADDPEACLAAANLAFAYRKRFKKDFVIDLIGYRRFGHNEMDEPMATNPTMYSIIQQHPTVRQLYAQKLIEKGIITKEAVEEMEREVAERLKIAYEKVPKDESKLDFIMDPPKPVASKLPFVKTSVEKDVLRRLNKELLQFPSDFHVFNKLERILKRREGVFDGKGKIDWAHAEILAFATILRDGVPIRLTGQDSQRGTFAQRHLVLHDMKTGEEFVPLHHISDANASFVVYNSPLTEAAVLGYEYGYNVFAPETLVLWEAQFGDFANMAQVMFDQFISSGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRLERFLQLAAENNWTVANLSTAAQYFHILRRQAGILQREEVRPLVLMTPKSLLRHPLAASDVEEFTNGQFHPVIEQKGLGENREKVERIILCTGKFAIDLAEQINKMEGLDWLHIVRVEELYPFPKEELQAIFARYPNVKEIIWAQEEPKNMGSWCYVEPKLREIAPDEVDVSYIGRRRRASPAEGDPVVHRKEQERIIQCALTKKEQ
What is the function of this protein?
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
2-oxoglutarate dehydrogenase E1 component, Alpha-ketoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
Protein: ECT_ACRMI
Sequence: MMQASFSICILSFYLLSFCHGAPLPAFLRSVLSGNGMKEESRVLKRSAPVMQDEIPVCAQNQTDRYSSSSRLCRLVKDLGFCDFDDLYQTVLQSCPIGCGFCRVEDGNWSVWGAWSPCSATCGDGQRSRSRSCTNPPPSGGGADCLGVSQEIEDCNRRSCEGIGGWSNWGQWSACSESCNIGIQARTRTCTNPPPTIPEGACEGFSFETQICSTSGCNVSASVSTAAATTSPVSSTAQTQIGPTVVSLTAKQQACLDAHNAKRAIHGSPPLEWDFTLAMNADEWANELAVTRQLEHDPNIMNEGENLFKSAGALECVDAVERWFLEGKDYDYEDDNKLDDDTSNFTQLVWRNTTRVGVATVVEVVSEGSVETYIVARYTPPGNIEGKFEENVIKPSAEAL
What are the official names of this protein?
Ectin.
What are the subcellular locations of this protein?
Secreted.
Protein: FOLD_XANCP
Sequence: MTAPAPAALAPARLLDGRRIAEELLDGLKLRVDARLAAGKTRPGLAVVLVGGDPASSVYVRNKRRAAEKVGIEAFDYDLPQGTTEAELAALIDQLNTDPKIHGILIQLPLPGIPDANRLIQRIDPRKDVDGFHPQNVGHLALREFGLRPCTPRGIVTLLAHTDQPVRGRNATIVGVSNHVGRPMGLELLIAGCTVTSCHKFTPPDVLEASVRNADILVVAVGRPGLIPGEWVKPGAVVIDVGINRLDDGRLVGDVGFEAAAQRAGWITPVPGGVGPMTVATLMQNTLEAADAAG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: LPXB_SHELP
Sequence: MNQSNQKVFAMVAGELSGDILGAGLIKALKQQYPDARFVGIGGPQMDALGFESLFSFEELAVMGLVEVLSRLPRLLKVRKTLIDELTALKPDCFIGIDAPDFNIGLELKLKAQGIKTVHYVSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDKHNVPCTFVGHTLADDIPLESDKLSARETLGLDPHAEYLAILPGSRGGELKQLAEPFVQAAVKLRQRYPDLKFVTPLVNAKRRAQFELALKTHAPDLDIHLVEGQSRTVMAAADAILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKGMMQISHYSLPNLLAGREIIPELIQADCTPDKIVDAVSNQLDGDHKPLMESFMTLHQQLRCDASARAAQAVIELVETK
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: RSMG_RHILW
Sequence: MELNGLRVSRETQERLQHFAALFQKWAKTINLVAPSTLDDLWNRHIADSSQVFQIHPKPVIWADLGSGGGFPGVITAIFLAELQDGWVHLVESNHKKAAFLRTALRETNARGSVHSSRIEDAHAEIGECGAISARALADLDGLLEYSAPWMLGEKDCRGFFHKGRDYLREIDKARGRWEFDLLEHSSAVEQESVILEISNLRRLV
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSN1_MOUSE
Sequence: MQIDVDPQEDPQNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPPLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM
What is the function of this protein?
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.  Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 1, SGN1, Signalosome subunit 1, G protein pathway suppressor 1, GPS-1, JAB1-containing signalosome subunit 1.
What is the protein family that this protein belongs to?
Belongs to the CSN1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GLYA2_HAHCH
Sequence: MFTRDMTIASFDPDLWTAMQGETQRQEEHIELIASENYTSPRVMEAQGSALTNKYAEGYPNKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHSGSQANAAVYMALCKPGDVILGMSLAHGGHLTHGASVSFSGRIYKAVQYGLNPETGEIDYEEVAKLARENKPKMIVAGFSAYSRVIDWERFRAIADEVGAYLFVDMAHIAGLVAAGVYPSPVQIADVTTTTTHKTLGGPRGGLILAKANEELEKKLNFAVFPESQGGPLMHVIAAKAVCFKEAMTDEFKQYQAQVVKNARVMADTFIQRGYDIVSGGTDDHLFLVDLIKKDITGKDADAALGRANITVNKNAVPNDPRSPFVTSGLRIGTPAITRRGMGEVEAKELTDWICDVLDDIENEETIQRVKQQVLELCKKFPVYKG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 2, SHMT 2, Serine methylase 2.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOL6_DROSI
Sequence: MPGKLVGSSEEAARTGTQANAHAEDHSDLEHSAPSTDDGFDEPKPPIAKSVPPSTAIPKKNNFKHRGDTKNVKPPTLEEMKELRDTQNLFHSNLFKLQVKEMLEELQLKQKYTDFIENWLESFTVFTRQLKDGLMERTHLEVPMKLSEKPTGFVFSKPTREPYLIGAAATGTLLGPKIVVDVALEMPKESLHKEDYLNLRYDQKRALYLTYVTERMMESQNYAQDQFNFNYYANNPLKPVLELIPVTKQVNKHLQVRLFITAPLSSFKPGRFVPWNNNIRPSFYGDEWDEQDPLPSTQHYNANVLFDLTLSENQAQLDKAFKSRRNFQDGLLLLKVWLRQRQLDIGYSGFGAHILAAFIVYLNKQRILHQSSSSYQVARTVWNQLANTDWTKGISLAVDPIQTEELNKFAKHYDVCFIDFTGQHNLCANIPLYLYQRVREEAKLAVELLNDMKLNSFPLIFMQKCPLYSRVDNILKISNYSCINQMLTLHSQPRIKYDFANYGYPQLLHLLTELLKKGLAERVHSILPLETATAAWPVENKAPVIGKYIQLGLILQPEHAYEVLNKGPAANDDPAGAEEFRRFWGEKSNLRRFQDGSITEAVVWGTAQDSPAKKRLIVRHIVLHLLEHHLQLDSKEVQYIGGELDQVYKLSPWFKVNKLKTKLSLDQDTDAEALSPHVIRCYDELARQLHGLNDLPLEIVSISGVSPIFRYCEPQPVLPQALLVENRILASTIQRVVIQLGQSGKWPTELSALRALKTAFLIEIGEKLEAQCRLHWVISADGLLVLKQGYCFLIELAHNKELALLKQEVTERGITTYVDNAASRFLERQHYILPKVSGALHSLHQTYSAFGSTVLLAKRWLATQLLDDGLWPDMATELLVAHLFQQRYAPQSIAAPQTGFIRFLQLLSHSDFNGELFLLNFNNSWQEQQIADLEHNYRSNRQSYPPLAVATSYDMQHAGRLWTSDQSPSQRVLGHVTRLARRALEIIETSLMSKDLRFVRPAQLFRASNEGYDLVIQFKPDLVPNSLSYDLGSPFVSFSQPNFSLPRAGSDYIARIVGLLRSAYSDFAAFFYNPHGGKELAIVWRPTTEFAAKPFKVTELQACSPSGNGKVQVLKETLLEDFKLLLKDFYLRIATPEELKREQREHQKPMRYFEANQAVAESKPKPKKHGKRKGTGKAAPPKKKRLIKSSTLKALK
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
Nucleolar protein 6, Maternal transcript 89Ba.
What is the protein family that this protein belongs to?
Belongs to the NRAP family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PSD_NEIG2
Sequence: MNRLYPHPIIAREGWPIIGGGLALSLLVSMCCGWWSLPFWVFTVFALQFFRDPAREIPQNPEAVLSPVDGRIVVVERARDPYRDVDALKISIFMNVFNVHSQKSPADCTVTKVVYNKGKFVNADLDKASTENERNAVLATTASGREITFVQVAGLVARRILCYTQAGAKLSRGERYGFIRFGSRVDVYLPVDAQAQVAIGDKVTGVKTVLARLPLTDSQADPVSQAASVETAANPSAEQQQIEAAAAKIQAAVQDVLKD
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ZMYM3_HUMAN
Sequence: MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEEETTSIATARRGSPGQEEELPQGQPQSPNAPPSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGDGLTAKASEKPPERKRSERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVSQRAGRSAVGTKMTCAHCRTPLQKGQTAYQRKGLPQLFCSSSCLTTFSKKPSGKKTCTFCKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQQQRPIPQSGDPADATRCSICQKTGEVLHEVSNGSVVHRLCSDSCFSKFRANKGLKTNCCDQCGAYIYTKTGSPGPELLFHEGQQKRFCNTTCLGAYKKKNTRVYPCVWCKTLCKNFEMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLTGPPRPCSFCRRSLSDPCYYNKVDRTVYQFCSPSCWTKFQRTSPEGGIHLSCHYCHSLFSGKPEVLDWQDQVFQFCCRDCCEDFKRLRGVVSQCEHCRQEKLLHEKLRFSGVEKSFCSEGCVLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDGSTWDFCSEDCKSKYLLWYCKAARCHACKRQGKLLETIHWRGQIRHFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSPESKPQTPSQTKVENSNTVRTPEENGNLGKIPVKTRSAPTAPTPPPPPPPATPRKNKAAMCKPLMQNRGVSCKVEMKSKGSQTEEWKPQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPMFLPTTLESTDKIVETIEELKVKIPSNPLEADILAMAEMIAEAEELDKASSDLCDLVSNQSAEGLLEDCDLFGPARDDVLAMAVKMANVLDEPGQDLEADFPKNPLDINPSVDFLFDCGLVGPEDVSTEQDLPRTMRKGQKRLVLSESCSRDSMSSQPSCTGLNYSYGVNAWKCWVQSKYANGETSKGDELRFGPKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYEPDSIYYLCLGIQQYLLENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTVFSRVEEEHLWECKQLGVYSPFVLLNTLMFFNTKFFGLQTAEEHMQLSFTNVVRQSRKCTTPRGTTKVVSIRYYAPVRQRKGRDTGPGKRKREDEAPILEQRENRMNPLRCPVKFYEFYLSKCPESLRTRNDVFYLQPERSCIAESPLWYSVIPMDRSMLESMLNRILAVREIYEELGRPGEEDLD
What is the function of this protein?
Plays a role in the regulation of cell morphology and cytoskeletal organization.
What are the official names of this protein?
Zinc finger MYM-type protein 3, Zinc finger protein 261.
What are the subcellular locations of this protein?
Nucleus.
Protein: EMC4_BOVIN
Sequence: MTAQGSLVANRGRRFKWAIELSGPGGGSRGRSDRGGGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
What are the official names of this protein?
ER membrane protein complex subunit 4, Transmembrane protein 85.
What is the protein family that this protein belongs to?
Belongs to the EMC4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Could also be a single-pass transmembrane protein with cytosolic N-terminus and lumenal C-terminus.
Protein: RFWD3_AILME
Sequence: MAQEAMEYNVDEQLEHRVAEQPVPAEVVSTQGGPPPLQPLPTEVVSSQGAPPLLQPAPAEGTSSQVGPHLLQPAAQLSVDLTEEVELLGEDRVENINPGASEEHRQPSRVNRPIPVSSLDSMNSFISGLQRLHGMLEFLRPPSDHNVGPVRSRRRRGSASRRSRTVGSQRTDSARSRAPLDAYFQVSRTQPHLPSMSQDSETRNPVSEDLQVSSSSSSDSESSAEYEEVVVQAEDTRAVVSEEQGGTAAEQEVTCVGGGETLPKQSPQKTNPLLPSVSKDDEEGDTCTICFEHWTNAGDHRLSALRCGHLFGYKCISKWLKGQARKCPQCNKKAKHSDIVVLYARTLRALDTSEHERMKSSLLKEQMLRKQAELESAQCRLQLQVLTDECSKLHSRVQDLQKLTVQHRDQISQSPSGSQARSLNCLPSSQNQRKYHFQKTFTVSPTGNCRIMTYCDALSCLVVSQPSPQASFLPGFGVKMLSTANMKSSQYVPMHGKQIRGLAFSSRSKGLLLSASLDSTVKLTSLETNTVVQTYNAGRPVWSCCWCLDESNHIYAGLVNGSILVYDLRNTSSHIQELVPQKARCPLVSLSYIPRAASAAFPYGGVLAGTLENASFWELKMGFSHWPHVLPMEPGGCVDFQTESSTRHCLVTYRPDKNHNTLRSVLMEMSYKLNDAGEPVCSCRPVQTFLGGPTCKLLTKSAIFQNPENDGSILVCTGDEASNSALLWDAGSGSLLQELQADQPVLDICPFEANHSSCLATLTEKMVHIYRWE
What is the function of this protein?
E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage.  Plays a key role in RPA-mediated DNA damage signaling and repair.  Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination.  Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint.  May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome.  In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.
What are the official names of this protein?
E3 ubiquitin-protein ligase RFWD3, RING finger and WD repeat domain-containing protein 3, RING finger protein 201.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Cytoplasm. Note=In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies. In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair. This recruitment depends upon RPA2.