PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_ANASK
Sequence: MTVKPLRDVTPKPLEGEERLEQSLRPATFDDYVGQVKIVDNVKVYAAAARQRGESLDHVLLSGPPGLGKTSLAHILARELGVTLHVTSGPALVKKGDLAGLLTALAPRDILFIDEIHRLSPAVEEALYPAMEDYRFDVVLGAGLGAQTMEMKLERFTLVGATTRTGLLASPLRDRFPIQERLEYYGPAELKEIAVRAARKLGLPVDEDGAEELARRARGTPRIAIRLLQRARDFAQVEGDGRLTREVVDRTLRRLEVDARGLDAMDRRILAAVIDTFGGGPVGIDAVAAAVGEESGTLEDVYEPFLVREGYLARTPRGRVALPAAYAHLGRDRPGGKQGSLV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PPAC_STRA1
Sequence: MSKILVFGHQNPDSDAIGSSVAFAYLAKEAWGLDTEAVALGTPNEETAYVLDYFGVQAPRVVESAKAEGVETVILTDHNEFQQSISDIKDVTVYGVVDHHRVANFETANPLYMRLEPVGSASSIVYRMFKENGVSVPKELAGLLLSGLISDTLLLKSPTTHASDIPVAKELAELAGVNLEEYGLEMLKAGTNLSSKTAAELIDIDAKTFELNGEAVRVAQVNTVDINDILARQEEIEVAIQEAIVTEGYSDFVLMITDIVNSNSEILALGSNMAKVEAAFEFTLENNHAFLAGAVSRKKQVVPQLTESYNA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYT4_NEUCR
Sequence: MMRPSSRQPYVCWQCLSRKDSGQHIALNTRKARVASLSSLASWPISSASIAPRPTRQWDRTLRLFRERRQGLSTSTSLLGRKIPEISNEALEDFALPLEPDLQHLQDSQPKTTKRSAHLSIRQRLKQWEAENPEPFHSIPSDFALPDRPINAFTSKRSEHMLEIENIDNDNATAQVHDQDLIDTQVTPRVQAGDLVELKSEDWNIGVLAVCLGSFNGIDHFYAVTGKWFASSNFKSGFIVKNFITNSADLQPVIGALPSTVGDMSILVELQKLRAGPTREHGAGLITKMLDFQNTSRQIYQSNLERLSNPHRHLPEEEQLMTLGEIAEFLLPPKLKQSSTGFPPAALYAVYNNIRTFFDDFFHPLGQGTAGPSSIIFHVAARSDIENVARVERMVRDHYSPELLDRKSRREHDRLEPVLRQARLAIDHSRKMREWSSHGMLGPTTRVLPASTYSWSQDALTVIGVIHMWAASDVFPRSSKYQWIGAAVLRALGRYQDADVLDATVGWTFLQEIGWLMPWEIHARHSLRLPGLQVNRAGGLLPSPEEQQPAELDEDVLAPLRQDFYTSTVYCIDAPNAKEIDDGVSLEKTDKEGEYWIHVHIADPTSRIRPDSSLAKRAALMTQTSYLPGHVDKMISDEAVVAEFSLAPGRPSLTFSARLNEEGTLLDHKVTPGRIGDVVYITPQDVATAVGPVDAGIPKVSTPDVVLEVGTPPSAEDEAPTRKMTKPDELSEQNVKDLEILSRLAAAIHKVRIQKGSVPIFLPSPSADFSLVNARIEHTPSGFLACTNDPYISVKYSVSGGLHPIVDDLMGTANQIAALWCYERGIPIPFRTNLLAAQNEEALRAYTQDVIYPQLIAGKQPSLEEMRTLRNLLGGHDIAATPTFIYTMGVDIYTKATSPLRRYSDLLVHWQIQAALLEEHKRLAQGSQSLVIRKFDKYHLKPPMDDKQAARLGLPFTASHLENKVFPHLRVRERHAKTLANIDGRNELILQALVRAWRFGEGKEGQVPEKFTYTVVNVQNTCVRGRIDYFDLWAEIDLDNLAGFSLLSNMRAGDVLTVQLADVNVHMRKIVVKPVEFVQRGPERGRLFAEEQEGEGEVENGGEYIDVEHEVLQPQGR
What is the function of this protein?
Required for RNA 5'- and 3'-end processing and splicing.  May act on the RNA processing enzymes directly, or it may act on other regulatory molecules, which influence the activity or synthesis of these enzymes.
What are the official names of this protein?
Mitochondrial protein cyt-4.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS13_CLONN
Sequence: MARIAGIDLPKEKRVEVGLTYIYGIGINRSREILKETGVNPDTRVKDLSEEEVNTIRDYIGKNFVIEGDLRRTIALDIKRLVEIGCYRGIRHRRGLPVRGQKTKTNARTRKGPKRAISGKKNK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: AROD_METS3
Sequence: MYSQTKIAIPIFQAKKEDVIKVAEDCIEKGADVLEFRIDALDNPNFDDIKEIIEEINFPIIATNRISSEGGSFKGSEEERIDILLKCAPLVDYVDIELQSDDRYIKQIHDTGVTTIVSYHDFHKTPEINEIMYIVEKEQKLGDIAKVAFMPNDLDDTLKILAILSHCENTIAISMSDLGSYTRVMASKFDSPITFAAGRDVTAPGQIDIETMKSLLNMDLNLME
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: SIM17_HUMAN
Sequence: MQSLRPEQTRGLLEPERTKTLLPRESRAWEKPPHPACTKDWEAVEVGASSHDSDEKDLSSQETGLSQEWSSVEEDDESEGSQGFVEWSKAPQQTTIVLVVCVLFLFLVLTGMPMMFHI
What are the official names of this protein?
Small integral membrane protein 17.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PSTB_METBF
Sequence: MTEGIQNVSQPQIKIENLNLWYGEKQALKNVSMQIPKNSITALIGPSGCGKSTFIRCLNRMNDLINNCRIEGKVSIEGKDIYEPDVDAVELRKNVGMVFQKPNPFPMSIYDNVAYGPRIHGANKKDLDGVVEQALRSAAIWDEVSDRLKSPALSLSGGQQQRLCIARTLAVKPKTILFDEPTSALDPISTLRIEDLTMELKKDYTIVIVTHNMQQAARISDYTGFFLMGELIEFDQTRQIFQNPREKSTEDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ATPB_BRASO
Sequence: MATAANQIGRVTQVIGAVVDVQFEGHLPAILNSLETKNGGNRLVLEVAQHLGESTVRAIAMDTTEGLVRGQEVTDTGAPIRVPVGEGTLGRIINVIGEPIDEAGPVKADNVRAIHQEAPTYTDQSTEAEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIQELINNVAKAHGGYSVFAGVGERTREGNDLYHEFIESKVNADPHNPDPSVKSKCALVFGQMNEPPGARARVALTGLTIAEDFRDKGQDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGALQERITTTTKGSITSVQAIYVPADDLTDPAPATSFAHLDATTTLSRSIAEKGIYPAVDPLDSTSRMLSPLVVGEEHYAVARQVQQVLQRYKALQDIIAILGMDELSEEDKLTVARARKVERFMSQPFHVAEIFTGSPGKFVELADTIKGFKGLVEGKYDHLPEAAFYMVGTIEEAVEKGKKLAAEAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CAPSD_SHVX
Sequence: MNEEDLNRLNASGDLNGANNQRIPAGPSGVNQPIPSVTAGGQNQFRPSGGLGNQGSRPTESSNQDELLPTEAEIEAITSDVESNSVAPKATIREILDTLQAKRQNATPKDLFSLAWACYHNGSSRFVNLNTDAPCGITHADLKTLWKASATLRQFCSYYAKSCYVSGKQQKKPPANWSRKGYPEEAKFAGFDFFNAVLSESSPAPPGGMRFKPTQAEILGHSMNAKMSIVESRQSSHMVSTRADLLGRQQINEQPKPPMITF
What is the function of this protein?
Required for genome encapsidation.  Forms ribonucleoprotein complexes along with TGB1 helicase and viral RNA.
What are the official names of this protein?
Capsid protein, CP, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the potexvirus capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: FGFH_NPVOP
Sequence: MHRLALVVATVAYLCAGHAPLQHITGTQRLVQVLIHNRYLAVRSDGTVGGTTYASSLDTVLQRIAIAHGRILLRNAVSCMYVCLDRCGAMYASAALSSDCILNEVMLENNYDVMFKIYNGKKTYVALDNTGNPRRVQLPRQRPLRMMNVYTFIMRIPLNYISVSQCAKPNKVIRHRKLPLVVQTTLNTISIYIITHVTMLFDHVD
What are the official names of this protein?
Fibroblast growth factor homolog.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
Protein: TUSC_YERPG
Sequence: MARKRIAFIFTQGPHGSSAGREGLDALLATSALSEDIGVFFISDGVLQLLPQQQPEKILARNYIATFGVLPLYDVENCYLCERSLQQRGLSKMADWILDVTVLSPADLRRELGTYDVVLTF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGB2_PVXX3
Sequence: MSAQGHRLTAPVNSEKVYIVLGLSFALVSITFLLSRNSLPHVGDNIHSLPHGGAYRDGTKAILYNSPNLGSRVSLHNGKNAAFAAVLLLTLLIYGSKYISQRNHTCACGNNHSSH
What is the function of this protein?
Plays a role in viral cell-to-cell propagation, by facilitating genome transport to neighboring plant cells through plasmosdesmata,.
What are the official names of this protein?
Movement protein TGB2, 12 kDa protein, Triple gene block 2 protein, TGBp2.
What is the protein family that this protein belongs to?
Belongs to the Tymovirales TGBp2 protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane.
Protein: LEU3_NITOC
Sequence: MSKKIALLAGDGIGPEIIAEAVKVLAALGEHGELDVVLESGLIGGAAYEVTGTPLPAETLALAQDSDAILLGAVGGPQWETLDIKVRPEKGLLGIRSALGLFANLRPAILYPQLVGASTLKPEVVSGLDLMIVRELTGGIYFGQPRGVCRLEHGERQGFNTLVYKESEIRRIAQVAFTIAMKRDRRVCSVDKANVLEATELWREVMSEVAAEFPEVELSHMYVDNAAMQLVRAPKQFDVVVTTNMFGDILSDCAAMLTGSIGMLPSASLDQSGRGMYEPIHGSAPDIAGQGIANPLATILSVAMMLRYSLDSPAQATRLEKAVGAVLDQGLRTPDIYSPGTTQVSTGAMGDAVVEAFIHTPG
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_THET8
Sequence: MRVVVVGTRGSALALAQTRFVVERLKETWPETEFKIRTIKTRGDQGASPREEAIFVKEIQEALLSREIDIAVHSLKDLPTESPRGLKIASVPRRQDPRDVFLGKAAKRLKDLPPGAVVGTSSVRRKAQILALRPDLVVRDLRGNVDTRLAALGNGEYDGIVLAAAGLIRLDLRNRIDEFLDPGEVLPAPGQGALALEVREGDDLAEELCYALHHPPSYHRVRAERAFLRGLGAGCLAPVGALAHVEEDGTLRLEGVLLTPDGKSFIRAEIEGDVSEAEELGLDLARDVLEQGGREILAQIR
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: GRPE_ECOBW
Sequence: MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKVANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_SOLUE
Sequence: MGRSVKKGPFTDTHLEAKLMVLNAASEKKVVRTWSRRSTILPEFVGHTIAVHNGKKFIPVYVTENMVGHKLGEFSPTRTFKGHSVKAATEKSSKPS
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: LLDD_ACIAD
Sequence: MIISSSNDYREAAKRRLPPFLFHYIDGGAYAEYTLKRNVEDLSQIALRQRVLNDMSSLSLETKLFNETLSMPVALSPVGLTGMYARRGEVQAAVAADKKGIPFTMSTVSVCPIEEVTPAIKRPMWFQLYVLRDRGFMKNALERAKAAGCSTLVFTVDMPVPGARYRDAHSGMSGPNAAMRRYLQSMMHPQWAWDVGLLGRPHDLGNISKYLGKTTGLEDYISWLGSNFDPSISWKDLEWIREFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVMSSARAMPAIAEAVKGDLTILADSGIRNGLDVVRMLALGADSVMLGRAFIYALAAQGGQGVSNLLDLIDKEMRVAMTLTGAKTIADINESCLVEMNKLIQS
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AMPA_NITEU
Sequence: MDFAIRSDNPEKYRGDCIVVGVFESRKLTEAARVLDEAGKGHLGRIVDQGDMDGRANTTLLLHGISGIDSKRVLLIGLGKEEEFGEKVFLDVVRTTFKALQPTGAKDVGLYLTELTVKGRDVAWNVLQTVILAEESAYRFDRLKSKPEGRQPSLAKVDIGITDTSTAAAVETALQQGLAIAHGMKVTKDLGNLAPNICTPSYLAGQAEEMARTFNLKFSVLEEKDMEELGMGALLAVARGSHQPAKLIVLEYHGGKDSEKPVALVGKGVTFDAGGISLKPAAEMDEMKYDMGGAASVFGTLTAVAELKLPINVIGVIPTTENLPGGNATKPGDVVTSLSGQTIEILNTDAEGRLILCDALAYTERYDPEVVVDIATLTGACVVALGHVVSGVMGNDEPLVQELLQAGEQTYDRAWHLPLFDEYQEQLKSNFADTANIGSRWGGAITAACFLSRFTKKFRWAHLDIAGTAWKSGKEKGATGRPVPLLTQFLISRANKH
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_JANMA
Sequence: MDPILALKAIIMGIVEGFTEFLPISSTGHLILAGSLLDFTGPKVKVFEIAIQTGAMLAVVWEYRAKIAAVLGGLLTERKAQKFALNIIIAFLPAALLGLVFASKIKEKLFAPVPVAIAFIVGGFIILWIEKRNRNTDFVARVETVDDMTMLDALKVGCAQAFALIPGTSRSGASIIGGMFFGLSRKAATEFSFFLAIPTLMGATVYSVYKDRALLSMADIPLFGLGGFAAFVSAFLCVRWLLRYISTHDFTFFAYYRIVFGLFVLLSAYYGWVVWAD
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KTHY_METJA
Sequence: MVDNMFIVFEGIDGSGKTTQSKLLAKKMDAFWTYEPSNSLVGKIIREILSGKTEVDNKTLALLFAADRIEHTKLIKEELKKRDVVCDRYLYSSIAYQSVAGVDENFIKSINRYALKPDIVFLLIVDIETALKRVKTKDIFEKKDFLKKVQDKYLELAEEYNFIVIDTTKKSVEEVHNEIIGYLKNIPH
What are the official names of this protein?
Probable thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RHAA_ECO57
Sequence: MTTQLEQAWELAKQRFAAVGIDVEEALRQLDRLPVSMHCWQGDDVSGFENPEGSLTGGIQATGNYPGKARNASELRADLEQAMRLIPGPKRLNLHAIYLESDTPVSRDQIKPEHFKNWVEWAKANQLGLDFNPSCFSHPLSADGFTLSHADDSIRQFWIDHCKASRRVSAYFGEQLGTPSVMNIWIPDGMKDITVDRLAPRQRLLAALDEVISEKLDPAHHIDAVESKLFGIGAESYTVGSNEFYMGYATSRQTALCLDAGHFHPTEVISDKISAAMLYVPQLLLHVSRPVRWDSDHVVLLDDETQAIASEIVRHDLFDRVHIGLDFFDASINRIAAWIIGTRNMKKALLRALLEPTAELRKLEAAGDYTARLALLEEQKSLPWQAVWEMYCQRHDTPAGSEWLESVRAYEKETLSRRG
What is the function of this protein?
Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
What are the official names of this protein?
L-rhamnose isomerase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_STAA8
Sequence: MKKKALLPLFLGIMVFLAGCDYSKPEKRSGFFYNTFVDPMKNVLDWLGNNLLNDNYGLAIIILVLVIRIILLPFMLSNYKNSHMMRQKMKVAKPEVEKIQEKVKRARTQEEKMAANQELMQVYKKYDMNPIKSMLGCLPMLIQLPIIMGLYFVLKDQLVDGLFKYPHFLWFDLGRPDIWITIIAGVLYFIQAYVSSKTMPDEQRQMGYMMMVISPIMIIWISLSSASALGLYWSVSAAFLVVQTHFANIYYEKVAKKEVQPFIEAYEREHNGGSNKKGKNTQVVSKKKKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BACE1_RAT
Sequence: MAPALRWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKSVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK
What is the function of this protein?
Responsible for the proteolytic processing of the amyloid precursor protein (APP).  Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity).  Cleaves CHL1 (By similarity).
What are the official names of this protein?
Beta-secretase 1, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane raft. Lysosome. Late endosome. Early endosome. Recycling endosome. Cell projection, axon. Cell projection, dendrite. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (By similarity).
Protein: Y061_ATV
Sequence: MLEGLFKNKKQEEADEGDQVLILDILDEERTMLPPGFEIVSTTQDGKIIAKDREGHLWVIK
What are the official names of this protein?
Uncharacterized protein ORF61.
Protein: HELS_THEAC
Sequence: MKISELGYDRAFLQLFDGNDFQLYDHQRMAIEQIRKGRNVVVSVPTAAGKTLIAYSAIYETFQRNLKSIYIVPLRSLAMEKFSELSRLRDLGLKVKMSIGDYDDSPDFIKRYDAVILTSEKADSLLHHDPYILNDVGLLVLDEIHTIGDESRGPTLETVASIARYVNPDVRILALSATVSNAMELASWLDASLIKSDFRPVPLKTGILYRDQLYLDGKRRSGVSINQIIRETVEDNGQVLMFVSSRKKAEDTARDLAQIFGSDANIKISSDETNVYDDMLNEILPRGVAFHHAGLSNDQRAFIEREFRARRIKVIVATPTLAAGVNLPARLVIVRDITRWGSDGISYLTNMEIKQMIGRAGRPGYDQYGIGLIYVSSQSSYEAAKDYLSTDPEPVVSYLGNEAKVRFNTLAAISMGLARSPSDIMKFYETTLFFSQNGKDLLEEKISASLKFLEKNGFIKQSPDLRTTQLGKVTSDLYIDPESALRLVDFFDGPADVDHAIYYISLCREIVPFNIKDDYSAMEFLDDIGLIDGDIDAAKTAIVLRDWISEASYKYLYDKYGIAPGDMQARISMADWLSYSLAKLSSIYKPEVRRMLEILNLRIKEGIREDILQLVLIPGVGRVRARRLYDAGLRSIEDVASASPDRIKAIYGFSDTLANAIIRRARTIASKEVR
What is the function of this protein?
DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
What are the official names of this protein?
ATP-dependent DNA helicase Hel308.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Hel308 subfamily.
Protein: ADC_CLOPA
Sequence: MLKSEVSKQISMPLTAPAF
What is the function of this protein?
Catalyzes the conversion of acetoacetate to acetone and carbon dioxide.
What are the official names of this protein?
Acetoacetate decarboxylase, AAD, ADC, CP 28/CP 29.
What is the protein family that this protein belongs to?
Belongs to the ADC family.
Protein: ATPE_MYCPN
Sequence: MQPLRFLVLSPSGIKLDQAIISAQVKTTNGYLGLNYNRAPLIAAVQSHFCKILFANNTRRNAIIGAGLVLIKKTEAKIFTENFVFEDEIDLEATLKRKAELERQMNHSKDLKLNIKIEQNLMFELLKLSNKQR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CYB_MELGA
Sequence: MAPNIRKSHPLLKTINNSLIDLPTPSNISAWWNFGSLLAVCLITQILTGLLLAMHYTADTTLAFSSVAYTCRNVQYGWLLHNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVVLLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFMIAGITIIHLMFLHESGSNNPLGISSNADKIPFHPYYSIKDILGLTIMLTPLLTLTLFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILLLIPFLHKSKQRAMTFRPLSQTLFWLLVANLLILTWVGSQPVEHPFIIIGQMASLSYFTILLILFPLIGALENKMLNL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.