PharMolix/UniProtQA huggingface dataset:
Protein: PTN14_MOUSE
Sequence: MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSRLQQEATRYQYYLQVKKDVLEGRLRCSLEQVIRLAGLAVQADFGDYNQFDSQEFLREYVLFPMDLAMEEAALEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDSHGNSVHLGIFFMGIFVRNRVGRQAVIYRWNDIGSVTHSKAAILLELIDKEETALFHTDDIENAKYISRLFTTRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPMHVQCSEHYSETHTSQDSIFPGNEEALYCRSHNSLDLNYLNGTVTNGSVCSVHSVNSLSCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSTIIVPSYRPTPDYETVMRQMKRGLMHADSQSRSLRNLNIINTHAYNQPEELVYSQPEMRERHPYTVPYAHQGCYGHKLVSPSDQMNPQNCAMPIKPGASSISHTVSTPELANMQLQGAQHYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGGGGGTVNKRHSLEVMNSMVRGMEAMTLKSLNIPMARRNTLREQGPSEETGGHEVHGLPQYHHKKTFSDATMLIHSSESEEEEETLEAAPQVPVLREKVEYSAQLQAALARIPNRPPPEYPGPRKSVSNGALRQDQGTPLPAMARCRVLRHGPSKALSVSRAEQLAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMTGPQAQKRPLMLAALNGLSVARVSGREDGHHDATRVPIDERLRALKKKLEDGMVFTEYEQIPNKKANGVFSTATLPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGSEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSGCYATTGLKVKHLLSGQERTVWHLQYTDWPHHGCPEDVQGFLSYLEEIQSVRRHTNSVLEGIRTRHPPIVVHCSAGVGRTGVVILSELMIYCLEHNEKVEVPTMLRFLREQRMFMIQTIAQYKFVYQVLVQFLQNSRLI
What is the function of this protein?
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition.  Mediates beta-catenin dephosphorylation at adhesion junctions.  Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner.  May function as a tumor suppressor.
What are the official names of this protein?
Tyrosine-protein phosphatase non-receptor type 14, Protein-tyrosine phosphatase PTP36.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
Protein: PO23_POPJA
Sequence: GTLANIIMLEHYIKLRRLKGKTYNVVSLDIRKAFDTVSHPAILRAMRAFGIDDGMQDFIMSTITDAYTNIVVGGRTTNKIYIRNGVKQGDPLSPVLFNIVLDELVTRLNDEQPGASMTPACKIASLAFADDLLLLEDRDIDVPNSLATTCAYFRTRGMTLNPEKCASISAATVSGRSVPRSKPSFTIDGRYIKPLGGINTFKYLGLTFSSTGVAKPTVYNLTRWLRNLEKAPLKPNQKFYILKTHLLPRLFYGLQSPGVTAGILQECDRLARRTTRKIFHLNVHTGSQFLHARIRDGGLGLVQMRYRIPCILSKRLGSLKQGNDTTNWSDIFNIEGPARSFYFRIRFLSSKGDPDPYWREEIRTRPLSSGLQDAADDASSRSWLNTIPRGWTGRDFVRAVQLRTGNLATQGLPYMAPEHRGCRNGCPRTESLSHVLQGCPLTHHERIKRHNELVAKVAKHARKKGWTTEVEPYVYHQDGQLYKPDLAIHQPDNTLVICDVQVCWEGPRPLATSWDNKRLVYDNPRFREAAVRRWGDKSLVFSPLLLGARGIWPRANVPTCNILSIPTTLRASCVHTCLKWGSTIHRHFMAGVWRRRPPDPPRPVPP
What are the official names of this protein?
Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2, Retrovirus-related Pol polyprotein from type I retrotransposable element R2.
Protein: RS12_DEHMB
Sequence: MPTVNQLVRKGRTSAAKKYKAPALHYSFNSLRNKVAFGDGSPQKRGVCTQVKTTTPKKPNSALRKIARVRLSNHMEVTAYIPGEGHNLQEHSVVLIRGGRVPDLPGVRYHIIRGTLDTAGVANRQQGRSRYGAKKGKAAPAKKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: Y8335_ORYSJ
Sequence: MTVELEKIAGSFFISKGWKTFVHRTGLLSGQYIRFQVLTPSKINVLLFDKKKDSKLPMIPSSKKQIKTAPKRSTGITINDMPTSKHASMLISHTSNKETSSDSRTESMTDIPSSSDNSGETTRSFDDLCFCARNTAVTPDIKNYISIIGQFLQRSSKFYIVTMNNTFMKQDRLCKLSLLTNMLMCDVLTDTCRFTLPSFLMAFFQNTVQTQTLTTCADSPYPYEHLRKTEPACREIDEVTLTMCAHSPYPYEYLRKTELACREIDEVTTGASLSTNILPPYTSSPLEAISGGEDIWWLAASRMGWRGDVAAVQADSVDGNNSPFLCARSPTIGNGGADQPYLMVGKPHGWPCWGWDGAEMWLWCQSKNSGHCHIGWPVGVLVKGGRIYPGGGLPSKELAGMIGPYASGDWFELKRELPAKA
What are the official names of this protein?
Putative B3 domain-containing protein Os08g0333500.
What are the subcellular locations of this protein?
Nucleus.
Protein: PCGF5_HUMAN
Sequence: MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQVHETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQENGQDDTSKADKPKVDEEGDENEDDKDYHRSDPQIAICLDCLRNNGQSGDNVVKGLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFIYMTRWRLRGENFRCLNCSASQVCSQDGPLYQSYPMVLQYRPRIDFG
What is the function of this protein?
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332).  Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).  Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).
What are the official names of this protein?
Polycomb group RING finger protein 5, RING finger protein 159.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Note=Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome.
Protein: RIMK_PSEA7
Sequence: MKIAVLSRNPRLYSTRRLVEAGRERGHEMVVIDTLRAYMNIASHKPQIHYRGQPLEGFDAVIPRIGASVTFYGCAVLRQFEMMGVFPLNESVAIARSRDKLRSLQLLSRKGIGLPVTGFAHSPDDVPDLIEMVGGAPLVIKLLEGTQGIGVVLCETEKAAESVLEAFMGLKHNIMVQEYIKEAGGADIRCFVVGDKVIASMKRQAAPGEFRSNLHRGGSASLIKITPEERMTAIRAARVMGLNVAGVDILRSNHGPLVMEVNSSPGLEGIESTTGKDIAGIIIQYLEKNGGPHLARTKGKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: SOXA_ARTSP
Sequence: MSQNKSYRLPAEQSPAARIDRGEALVLSVDGKQLDAFRGDTVASAMLANGQRSCGNSMYLDRPRGIFSAGVEEPNALVTVAARHEEDINESMLAATTVPVTANLSATLLRGLGVLDPSTDPAYYDHVHVHTDVLVVGAGPAGLAAAREASRSGARVLLLDERAEAGGSLRDAAGEQIDGQDAAAWIDATAAELASAAETTHLQRTTVLGSYDANYVIAAQRRTVHLDAPSGAGVSRERIWHIRANQVVLATGAHERPIVFQNNDRPGIMLAGAVRSYLNRYGVRAGTRIVVATTNDSAYPLVADLAASGGVVAVVDARTTVSAAAAEAVGAGVRVITGSVVADTEANESGELSAVVVAELGEDRELGAPQRFEADVLAVAGGFNPVVHLHSQRQGKLVWDTSIHAFVPDTAVANQHLAGALTGLFDTASALSTGAATGAAAATAAGFERIAQVPQALAVPAGEARPVWLVPSLNGDQAANYTTHFVDLQRDQTVSDVLRATGAGLESVEHIKRYTSISTANDQGKTSGVAAIGVIAAVLGIENPAEIGTTTFRAPYTPVSFAALAGRTRGALLDPARITPMHSWHLAHGAAFEDVGQWKRAWYFPQDGEDMDAAVYRESKAVRDSVGMLDATTLGKIEIRGKDAAEFLNRIYTNGYTKLKVGMARYGVMCKADGMVFDDGVTLRLAEDRFLMHTTTGGAAGVLDWLEEWLQTEWPELDVTCTSVTEQLATVAVVGPRSRDVVAKLASGLDVSNEAFKFMSFRDVTLDSGIEARISRISFSGELAYEIAIPSWHGLRVWKDVFAAGQEFNITPYGTETMHVLRAEKGFIIVGQDTDGTVTPQDAGMEWVVSKLKDFVGKRSFARADNLREDRKHLVSVLPVDTTLRLAEGAALVADGAVETGGCTPMEGWVTSSYNSPALGRTFGLALIKNGRSRIGEVLKTPVNGQLVDVLVSDLVLFDPEGSRRDG
What is the function of this protein?
Catalyzes the oxidative demethylation of sarcosine to yield glycine, hydrogen peroxide and 5,10-methylenetetrahydrofolate.
What are the official names of this protein?
Sarcosine oxidase subunit alpha, Sarcosine oxidase subunit A.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRS1_CANGA
Sequence: MSLKMKGKKYTDLDFVPTISDSEEDVPDLDSDEEKPKPETKGKKKNKSVDEESADMNSGFRFNTDDGEINTNFDGWEFLGDEKDEEKKDVDLDKIIRKKGGLIGMAHVDEAEKSESEESESDDEDLAMDGFGMGAQEQPEGEEEDEDASNSEQESNDEEEDDDEETYDVGDAGDAEEKVEEDTAEEMQAFYAPESESENAKKEVHKTFNDLALSRPVMKGLSNLGYVKPSPIQSATIPIALLGKDIIAGAVTGSGKTAAFMIPIIERLLYKPAKVASTRVIVLTPTRELAIQVADVGKKIGQFVSNLTFGLAVGGLNLRQQEQMLKTRPDIVIATPGRFIDHIRNSASFNVDSVEVLVIDEADRMLEDGFQDELNEIMSLLPSKRQTLLFSATMNSRIKQLISLSLKRPVRIMIDPPKQAATKLTQEFVRIRKRDHLKPSLLFNLIRKLDPNGQKRIVVFVARKDMAHKLRIILGLLGMAVAELHGSLTQEQRLDSVNKFKSLQVPVLICTDLASRGLDIPKIEVVINYDMPKSYEIYLHRVGRTARAGREGRSITFVGEASAERSIVKDAIRGVNDSEIPGSKAVGRNVDWNQVEETNKIVENMDQTVQDILVEEKEEKEILRAEMELKKGENLLKHKDEIQSRPKRTWFQSEKEKKNSKIMGALSKTKKEVNSKKRKRNEAMEDGHKRSYKKTQSDRTADQERTMKKQAKANGKKKGKSKGKR
What is the function of this protein?
ATP-binding RNA helicase involved in ribosome assembly.
What are the official names of this protein?
ATP-dependent RNA helicase DRS1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL402_SCHPO
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCEKQICRKCYARLPPRATNCRKKKCGHTNQLRPKKKLK
What is the function of this protein?
Component of the 60S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-60S ribosomal protein L40.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [60S ribosomal protein L40]: Cytoplasm.
Protein: MATK_AMOTI
Sequence: MEELKGYLEKSRSKQQHFLYPLLFQEYIYALAHDHGLNVNGSFFYEPAEISGYDKKFSSLLAKRLITRMYQQNYLINSVNDSNQNRFVGHNRNFYSQMISEGFAVIVEIXFSLRLVSSLEEKKEIPKSQNLRSIHSIFPFFEDKLSHLNCVSDILIPYPVHLEILVQILQCWIQDVPSLHLLRFFFHEYHNWNNLITPKKSNYYGFSKENPRLFLFLYNSYVVECESILVFLRKQSSYLRSTSSGTFLERAHFYEKIEQHLVVLCCNDFQKTLWLFKDPFMHYVRYQGKSILASKGTHLLMKKWKSYFVNFWQCHFHFWSQPCRIHINQFSNFSFYFLGYLSSVPINPSAVKSQMLENSFLVDTATKKFETIVPIIPMIGALSKAKFCNVSGNPISKPVWADLSDSDIIDRFGRTCRNLSHYYSGSSKKQSLYRIKYILRLSCARTLARKHKSTVRAFLQRLGSEFLEEFFTEEEKALSLILPRISYPLHKLYRERIWYLDIIRINDLVNHL
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TEG7_HHV7J
Sequence: MGNCFVKKISSDIFNSNYQMLYSELSEQEDLLDFLETKYTDFGILKTDILNYERDSETFKTLLQVLPIYKKTKLRYNLIERCLNNCPPHVKDALIIEIMKAKKILETLDVVFMKIMIGEFTICSDNVNQLLNKFSIDQTTLCDMEKINTLIDLDEENSKRLLTEIDPLLHQETGLYQALPNAVTDPPSEQRAATKKCYEGFTK
What is the function of this protein?
Plays several roles during the time course of infection, including egress of virus particles from the perinuclear space and secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes.
What are the official names of this protein?
Tegument protein UL51 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL51 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host Golgi apparatus.
Protein: GNAT2_STRCL
Sequence: MSDSTPKTPRGFVVHTAPVGLADDGRDDFTVLASTAPATVSAVFTRSRFAGPSVVLCREAVADGQARGVVVLARNANVATGLEGEENAREVREAVARALGLPEGEMLIASTGVIGRQYPMESIREHLKTLEWPAGEGGFDRAARAIMTTDTRPKEVRVSVGGATLVGIAKGVGMLEPDMATLLTFFATDARLDPAEQDRLFRRVMDRTFNAVSIDTDTSTSDTAVLFANGLAGEVDAGEFEEALHTAALALVKDIASDGEGAAKLIEVQVTGARDDAQAKRVGKTVVNSPLVKTAVHGCDPNWGRVAMAIGKCSDDTDIDQERVTIRFGEVEVYPPKARGDQADDALRAAVAEHLRGDEVVIGIDLAIADGAFTVYGCDLTEGYVRLNSEYTT
What is the function of this protein?
Catalyzes the biosynthesis of ornithine by transacetylation between N(2)-acetylornithine and glutamate.  It can also use L-arginine, L-glutamine and L-lysine as acetyl acceptors.
What are the official names of this protein?
Glutamate N-acetyltransferase 2, Ornithine acetyltransferase 2, Ornithine transacetylase 2, OATase 2.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD3_RAT
Sequence: MGASGRLLRAVIMGAPGSGKGTGSSRITKHFELKHLSSGDLLRQNMLQGTEIAVLAKSFIDQGKLIPDDDMTRLALHELKNLTQCSWLLDGFPRTLPQAEALDRVYQIDTVINLNVPFEVIKLRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTETNKIRPHVYSFLQMKVPETIQKASVTP
What is the function of this protein?
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates.  Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
What are the official names of this protein?
GTP:AMP phosphotransferase AK3, mitochondrial, Adenylate kinase 3, AK 3, Adenylate kinase 3 alpha-like 1.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: COG5_HUMAN
Sequence: MGWVGGRRRDSASPPGRSRSAADDINPAPANMEGGGGSVAVAGLGARGSGAAAATVRELLQDGCYSDFLNEDFDVKTYTSQSIHQAVIAEQLAKLAQGISQLDRELHLQVVARHEDLLAQATGIESLEGVLQMMQTRIGALQGAVDRIKAKIVEPYNKIVARTAQLARLQVACDLLRRIIRILNLSKRLQGQLQGGSREITKAAQSLNELDYLSQGIDLSGIEVIENDLLFIARARLEVENQAKRLLEQGLETQNPTQVGTALQVFYNLGTLKDTITSVVDGYCATLEENINSALDIKVLTQPSQSAVRGGPGRSTMPTPGNTAALRASFWTNMEKLMDHIYAVCGQVQHLQKVLAKKRDPVSHICFIEEIVKDGQPEIFYTFWNSVTQALSSQFHMATNSSMFLKQAFEGEYPKLLRLYNDLWKRLQQYSQHIQGNFNASGTTDLYVDLQHMEDDAQDIFIPKKPDYDPEKALKDSLQPYEAAYLSKSLSRLFDPINLVFPPGGRNPPSSDELDGIIKTIASELNVAAVDTNLTLAVSKNVAKTIQLYSVKSEQLLSTQGDASQVIGPLTEGQRRNVAVVNSLYKLHQSVTKAIHALMENAVQPLLTSVGDAIEAIIITMHQEDFSGSLSSSGKPDVPCSLYMKELQGFIARVMSDYFKHFECLDFVFDNTEAIAQRAVELFIRHASLIRPLGEGGKMRLAADFAQMELAVGPFCRRVSDLGKSYRMLRSFRPLLFQASEHVASSPALGDVIPFSIIIQFLFTRAPAELKSPFQRAEWSHTRFSQWLDDHPSEKDRLLLIRGALEAYVQSVRSREGKEFAPVYPIMVQLLQKAMSALQ
What is the function of this protein?
Required for normal Golgi function.
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 5, COG complex subunit 5, 13S Golgi transport complex 90 kDa subunit, GTC-90, Component of oligomeric Golgi complex 5, Golgi transport complex 1.
What is the protein family that this protein belongs to?
Belongs to the COG5 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein.
Protein: PG142_VACCA
Sequence: MFVDDNSLIIYSTWPSTLSDSSGRVIVMPDNRSFTFKEGFKLDESIKSILLVNPSSIDLLKIRVYKHRIKWMGDIFVLFEQENIPPPFRLVNDK
What is the function of this protein?
Late protein which is a part of a large complex required for early virion morphogenesis.  This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions.  Required for the stability and kinase activity of OPG054.
What are the official names of this protein?
Core protein OPG142.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG142 family.
Protein: THTR_PSEAE
Sequence: MSVFSDLPLVIEPSDLAPRLGAPELILVDLTSAARYAEGHIPGARFVDPKRTQWGQPPAPGLLPAKADLEALFGELGHRPEATYVVYDDEGGGWAGRFIWLLDVIGHHHYHYLNGGLPAWIADAQALDREVPAPVGGPLPLTLHDEPSATREYLQSRLGAADLAVWDARNPSEYAGTKVLAAKAGHVPGAINFEWTAGMDPARALRIRADIAEVLEDLGITPDKEVITHCQTHHRSGFTYLVAKALGYPRVKGYAGSWSEWGNHPDTPVEV
What is the function of this protein?
Catalyzes the sulfur transfer reaction from thiosulfate to cyanide, thus converting cyanide to the less toxic thiocyanate (PubMed:15522204).  Contributes to P. aeruginosa survival under cyanogenic conditions, and thus provides the bacterium with a defense mechanism against endogenous cyanide toxicity (PubMed:17098912).  Is the main cytoplasmic rhodanese in P. aeruginosa, accounting for 90% of total rhodanese activity (PubMed:17098912).
What are the official names of this protein?
Thiosulfate sulfurtransferase, TST, Rhodanese RhdA, Thiosulfate:cyanide sulfurtransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OLF3A_DANRE
Sequence: MRALQLLVLVLSGLVGAQQQALMDYLERRLLAIEDRISLWHEQTSRYASELREFKQQMVAQLEGLDKSKEALRSELDTVGTRVDRVEREMDYLETQNGAQPCVDVDDKLVEQQVTFVKERNKAKYAKLTDCSDMISSIKAMKILKRVGGAKGMWTKDMGSATGKVYILNGTDDNTVFEFGTVREFTSSQGTSGATTIQLPSAWRGMGHAIYNNHMYYLKQGEEMKLIKFDLQKNIIVDSAVFPVKNQLPVYSLNPETFIDLAVDEEGLWAIYATQENERHISLAKIDPKTLDIQQMWDTPCVRENAEAAFVICGTVYVVYNSKLPSRSRIQCVFDVSDMVNNDEAPHVYFPKRYGTHSSLKYSPVEQLLYAWDDGYQILYKLQLKKKLEV
What is the function of this protein?
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development.  Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side.  Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity).
What are the official names of this protein?
Olfactomedin-like protein 3A.
What is the protein family that this protein belongs to?
Belongs to the OLFML3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRDX6_PONAB
Sequence: MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPGTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGRKYLRYTPQP
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity).  Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity).  Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity).  These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity).  Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity).  Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity).  Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity).
What are the official names of this protein?
Peroxiredoxin-6, 1-Cys peroxiredoxin, 1-Cys PRX, Acidic calcium-independent phospholipase A2, aiPLA2, Glutathione-dependent peroxiredoxin, Lysophosphatidylcholine acyltransferase 5, LPC acyltransferase 5, LPCAT-5, Lyso-PC acyltransferase 5, Non-selenium glutathione peroxidase, NSGPx.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome. Note=Also found in lung secretory organelles (lamellar bodies).
Protein: IF4A3_XENTR
Sequence: MAAAAVTAVAGVTSGSSRKRLLREEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFCVSVLQCLDIQVRETQALILAPTRELAGQIQKVLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVCLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
What is the function of this protein?
ATP-dependent RNA helicase.  Involved in pre-mRNA splicing as component of the spliceosome.  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity).  Involved in craniofacial development (By similarity).
What are the official names of this protein?
Eukaryotic initiation factor 4A-III, eIF-4A-III, eIF4A-III, ATP-dependent RNA helicase DDX48, ATP-dependent RNA helicase eIF4A-3, DEAD box protein 48, Eukaryotic translation initiation factor 4A isoform 3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: KCNC4_HUMAN
Sequence: MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACADGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH
What is the function of this protein?
This protein mediates the voltage-dependent potassium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
What are the official names of this protein?
Potassium voltage-gated channel subfamily C member 4, KSHIIIC, Voltage-gated potassium channel subunit Kv3.4.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RHAA_ECOLI
Sequence: MTTQLEQAWELAKQRFAAVGIDVEEALRQLDRLPVSMHCWQGDDVSGFENPEGSLTGGIQATGNYPGKARNASELRADLEQAMRLIPGPKRLNLHAIYLESDTPVSRDQIKPEHFKNWVEWAKANQLGLDFNPSCFSHPLSADGFTLSHADDSIRQFWIDHCKASRRVSAYFGEQLGTPSVMNIWIPDGMKDITVDRLAPRQRLLAALDEVISEKLNPAHHIDAVESKLFGIGAESYTVGSNEFYMGYATSRQTALCLDAGHFHPTEVISDKISAAMLYVPQLLLHVSRPVRWDSDHVVLLDDETQAIASEIVRHDLFDRVHIGLDFFDASINRIAAWVIGTRNMKKALLRALLEPTAELRKLEAAGDYTARLALLEEQKSLPWQAVWEMYCQRHDTPAGSEWLESVRAYEKEILSRRG
What is the function of this protein?
Catalyzes the interconversion of L-rhamnose and L-rhamnulose (PubMed:14243758, PubMed:2558952, PubMed:8564401, PubMed:1650346).  Can also catalyze the isomerization of L-lyxose to L-xylulose (PubMed:1650346).
What are the official names of this protein?
L-rhamnose isomerase, RhamIso.
What is the protein family that this protein belongs to?
Belongs to the rhamnose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.