PharMolix/UniProtQA huggingface dataset:
Protein: RPOC_CHRVO
Sequence: MKALLDLFKQVTQEEEFDAIKIGIASPDKIRSWSYGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTLSKVRRERMGHIELASPTAHIWFLKSLPSRLGMVLDMTLRDIERVLYFEAYVVTDPGMTPMQYRQLLTEEDFLDKEDQYGEEFVAMMGAEAVKELLKKLDLDAEIEGLRRELETTNSDTKIKKIAKRLKVLEAFQRSGMKPEWMILEVLPVLPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELRAPDIIVRNEKRMLQESVDSLLDNGRRGKAMTGANKRPLKSLADMIKGKGGRFRQNLLGKRVDYSGRSVITVGPTLRLHQCGLPKKMALELFKPFIFHKLEVMGLASTIKAAKKLVEQEVPEVWDILEEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQMEARTLMLATNNVLSPANGEPIIVPSQDIVLGLYYMTRDKVNGKGEGMVFADTKEVHRAYETRQVELATRITVRLKEWEKDEQGEFQPVIKRYNTTVGRAILSDILPKGLPFEHINKALKKKEISKLINVSFRRCGIRDTVIFADQLMYTGFAYSTRGGISICVDDMQIPVKKSELLGEANKEVKEIEEQYRQGLVTQGERYNKVVDIWGRTGDKIAKAMMDELSKQKVLDREGKEVDQESFNSIYMMADSGARGSAAQIKQLAGMRGLMAKPDGSIIETPITANFREGLTVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVTQDLVVIEDDCGTSNGFTMKAVLQGGDVIEALRDRILGRVTAVDVVDPSTGETVIEAGTLMDEHLVDLVDSLGIDEVKVRTAITCDTRYGLCAKCYGRDLARGKQVNAGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRNAAASQVEGKSNGTVRFSSQMRYVANTKGELIVITRSGEVVIHDDMGRERERRKVPYGATLMVTDGLQIKAGAVLATWDPHTRPIITEYAGRVKFENVEEGNTVAKQTDEVTGLSTLVVIDPKRRAGSQSKMLRPLVKLLDDNGNEVKLAGSDASVSITFQVGAIITVRDGQDVGKGEVLARIPQESSKTRDITGGLPRVAELFEARSPKDAGMLAEVTGTVSFGKDTKGKQRLIITDLEGNGYENLIPKDKHVLVHDGQVVNRGESIVDGPVDPHDILRLQGIEALARYIVQEVQEVYRLQGVKINDKHIEVIIRQMLRRVIITDSGDTEFIQGEQVERADVLEMNDKMMAENKEPAQYENVLLGITKASLSTDSFISAASFQETTRVLTEAAIMGKRDDLRGLKENVIVGRLIPAGTGLAYHRTRRRQNLGLDAGESMLFDPAPAALESGE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RL23_METEP
Sequence: MSADPRHYDIIVSPVITEKATNLTEQNKVVFRVAPKATKPQIKEAVERLFDVKVTGVNTLTTKGKKKFFRGQRGQRSDVKKAIVTLAEGDTIDVTTGL
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: CA1A_CONPR
Sequence: FDGRNAAANDKASDLVALTVRGCCSHPACSVNHPELCG
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.  This synthetic peptide potently and reversibly blocks alpha-9-alpha-10/CHRNA9-CHRNA10 nAChR (IC(50)=6. 9-54. 9 nM), alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=9. 7-97. 5 nM) and alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=11. 1-17. 2 nM) (PubMed:15983035, PubMed:21252227, PubMed:22914547, PubMed:23846688, PubMed:32101438).  It also inhibits alpha-6/alpha-3-beta-4 (CHRNA6/CHRNA3-CHRNB4) nAChR with a higher potency on human (IC(50)=6. 75 nM) than on rat receptors (IC(50)=130-147 nM) (PubMed:22914547, PubMed:33523678).  Also shows a weak ability to inhibit alpha-3-beta-4/CHRNA3-CHRNB4 (IC(50)=480-1500 nM) (PubMed:15983035, PubMed:22914547).  This synthetic toxin also inhibits N-type calcium channels (Ca2. 2/CACNA1B) (IC(50)=1. 1 nM) via the activation of the G protein-coupled GABA(B) receptor in DRG neurons (PubMed:21252227).  Also exhibits inhibition of D. melanogaster alpha-7 nAChRs (PubMed:25466886).
What are the official names of this protein?
Alpha-conotoxin PeIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RISB_FUSNN
Sequence: MKVFEGKFNGKGTKIAIVAARFNEFITSKLIGGAEDILKRHEVQDDDINLFWVPGAFEIPLIAKKLAQSKKYDAVITLGAVIKGSTPHFDYVCAEVSKGVAHVSLESEVPVIFGVLTTNSIEEAIERAGTKAGNKGADAAMTAIEMINLIKGI
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RS4_HALMA
Sequence: MALGSNTKFYETPNHPFQGERIADEANLIGRYGLKNKEELWRAQSELRGYRREARKLLGSAGEHETESEEFLARLKRYGILNEQDQLDDVLSLDVTDVLERRLQTVVYRKGYANTPEQARQFIVHGHIVLDDARVTRPGMTVETAVESSVGFDEHSSLSDELHPERAEAQE
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, HmaS4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RPOE_CERS4
Sequence: MTDKSDRTDWVALMRAIRDHRDEAAFAELFQHFAPKVKGFLMKSGSVASQAEECAQDVMATVWQKAHLFDPSRASVATWIFTIARNRRIDGLRKDRQPEPEDLFWGPDSEPDQADVYEMQQENARLGRAIARLPEAQRALIERAFFGDLTHRELAAETGLPLGTIKSRIRLALDRLRQHMS
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released.  Sigma-E controls a transcriptional response to singlet oxygen, a by-product of photosynthesis; its continuous activity requires constant exposure to singlet oxygen.  The regulon has about 180 genes that protect against or repair damage induced by singlet oxygen, including itself and rpoH2, a heat shock-responsive sigma factor.
What are the official names of this protein?
ECF RNA polymerase sigma factor RpoE, Alternative RNA polymerase sigma factor RpoE, RNA polymerase sigma-E factor, Sigma-24.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. ECF subfamily.
Protein: RAD5_ASPFU
Sequence: MVFGDLNERPLKKRRFFVDEEDTHPPSSEAAPVTTNLDTSTISSAGPEGSDVRQQQLNGAVPFPNVKESSRESPGLGPEDKQDNLLKEDEENNGTVDYEILNHSPSIHAQQDQRVDQGLTNGFGGQPSGERTVSETQAFQSSGGFDTSTFASIIGEHLSPESLEKIRKASGDDLERAVNIYFDGSWKSSNNSLSQPLVAPHQQTLSNPCTPVNESISQTVNTKISKKPNQAPSSRCLSQSSRYIGAFGVGAWATRSGVGLLKHGEHVNVERARSQPVSKRGRGGKLITNQKGDVLTRFTNKSGQEIGRLPRETAEWVSTLIDQKICRFEGICVFAPDRVRVNDTIYLQLWCYLRKEAFLPRNLWNMGDDNRSTAFFEEQESAEEKQLRLRQVALVKLFDEIGLQPTTVNDMTKKHKKEGLLRAAEIAEQYDKTKREGKSNESSEDEESPELEEDQLDTLYKKAQSFDFNMPEAQPPPSFVLNLRKYQRQALHWMLAKEKDKKSGRELSMHPLWEEYTWPTKDVDDKDLPAVEGQAHFYVNPYSGELSLDFPAQEQHCLGGILADEMGLGKTIEMLSLIHSHRNVSPSRQGPSSSTELVRMPSSSSAILPAPNTTLVVAPTSLLSQWESEAMKASEQGTMKVLMYYGVDKSTNLQELCSAGNPAAPNIIITSYGVVLSESRQLAMFNSNTQGGLFSVDFFRVILDEAHVIKNRRSKTARACYELRATHRWVLTGTPIVNRLEDLFSLVRFLQVEPWNNFSFWKTFITVPFESKDYVRALNVVQTVLEPLVLRRTKTMKTPEGEPLVPLPRRTIDIVEVELSEQEREIYDYIFTRAKRTFNDNIEAGTLLKSFSTIFAQILRLRQTCCHPILTRNKTIVADEEDAAATADAANELKDDMDLQELIDRFSASMENADTAEAQDPSAKFTTHALRQIQTESSGECPICSEEPMIDPAVTACWHSACKKCLEDYIRHQTDKGVPPRCFSCRAPVTSRDIFQVIRHQSPSSTPTETDLYSSTPASSPHPAPRISLRRIHPLSPSAHTSAKIHALINHLNRVPANTKSVVFSQFTSFLDLIGAQLTKAGISYVRLDGTMPQKARAEVLAEFNRTETFHQEEIDEDEGPDTPRVRISSKNSRSSPKSPAVLLISLRAGGVGLNLTAASNVFMMDPWWSFAIEAQAIDRVHRMGQLRDVSVTRFIVKDSIEGRMLRVQERKMNIAGSLGLRVGGDGSEDEKRKERIEELKLLFE
What is the function of this protein?
Probable helicase, member of the UBC2/RAD6 epistasis group.  Functions with DNA repair protein RAD18 in error-free postreplication DNA repair.  Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats.  Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).
What are the official names of this protein?
DNA repair protein rad5.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GATA_AQUAE
Sequence: MLWKKSLSELRELLKRGEVSPKEVVESFYDRYNQTEEKVKAYITPLYGKALKQAESLKERELPLFGIPIAVKDNILVEGEKTTCASKILENFVAPYDATVIERLKKAGALIVGKTNLDEFAMGSSTEYSAFFPTKNPWDLERVPGGSSGGSAASVAVLSAPVSLGSDTGGSIRQPASFCGVIGIKPTYGRVSRYGLVAFASSLDQIGVFGRRTEDVALVLEVISGWDEKDSTSAKVPVPEWSEEVKKEVKGLKIGLPKEFFEYELQPQVKEAFENFIKELEKEGFEIKEVSLPHVKYSIPTYYIIAPSEASSNLARYDGVRYGYRAKEYKDIFEMYARTRDEGFGPEVKRRIMLGTFALSAGYYDAYYLKAQKVRRLITNDFLKAFEEVDVIASPTTPTLPFKFGERLENPIEMYLSDILTVPANLAGLPAISIPIAWKDGLPVGGQLIGKHWDETTLLQISYLWEQKFKHYEKIPLT
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: HEM1_MANSM
Sequence: MTILVLGINHKTASVALREKVAFSPEKRDLAFQQIAQSELAQSEVILSTCNRTEIYLHNKHISPEADQENQRWLEQCIQWFADVHQLDVDELRNCLYIKQNQSAVNHLMRVSCGLDSLVLGEPQILGQVKQAYQYSEDYCQAQHMPMSSEFSRLFQKTFSVAKRVRTETNIGNSAVSVAYAACSLARQIFEGLKDLNILLVGAGETIELVARHLLRHGVKKLMISNRTLARAELLVEKLEHNKYIQVLSLQQLQDGLNQADIVISSTGSPIVLITAEMVKQAQQKRRNAPMLIVDIAVPRDVDERVEKLDGVYHYTVDDLHSIIQRNLSEREKASKEAETIIDAEASDFFEWMKVHQFSNLIRTYRESAEQIRQDLLEKAVQAIGQNEDPETVLQELSYKLMNKLIHSPTQAMQAMMKQGSIQGLRSFSSALGIADKKERNPQK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: HFQ_NEIG1
Sequence: MTAKGQMLQDPFLNALRKEHVPVSIYLVNGIKLQGQVESFDQYVVLLRNTSVTQMVYKHAISTIVPARSVNLQHENKPQAAPASTLVQVETVQQPAE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: RL5_RICBR
Sequence: MLRFKELYQKEIISNLQKEFSYKNKHEIPAIEKIVINMGVGEAIADSKVIDKAVNDLTLISGQKPFVTSARKSIATFKLRDGMKIGCKVTLRKDRMYDFLERLVIVALPRVKEFRGFSYKSFDGKGNFTFGLKEQIVFPEINYDKIDSIRGMDITIVTSAKTDKEGKSLLSGFNLPFYN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ARGR_CITK8
Sequence: MRSSAKQEELVKAFKALLKEEKFSSQGEIVLALQDQGFDNINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKDLYEAILELFEQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_NITWN
Sequence: MMTAETTGRAACLIGWPAAHSRSPLIHHYWLRLHGITGGYSIEAIPPEGFAEFVMHLSTHGFAGANVTIPHKERALQLTEPDDRARAVGAANTLYYEGAVLRSTNTDVEGFISNLDVAAPSWDRTGDALVLGAGGASRAVVFGLVERGIGRIHLANRTVERARVLADQFGATVIPAAWNTLGDLLPRVGLLVNTTSLGMKGQPPLDIELALLPRDAVVADLVYVPLETPLLSAARARGLRTADGLGMLLHQAVRGFELWFGLRPAVTQELRALVEADLL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: NRDI_STAA8
Sequence: MKIIYFSFTGNVRRFIKRTELENTLEITAENCMEPVHEPFIIVTGTIGFGEVPEPVQSFLEVNHQYIRGVAASGNRNWGLNFAKAGRTISEEYNVPLLMKFELHGKNKDVIEFKNKVGNFNENHGREKVQSY
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: PURA_BEUC1
Sequence: MPAVVVVGAQWGDEGKGKATDQLGSRVDYVVKFNGGNNAGHTVVIGDEKYALHLLPSGILTPDVTPVIGNGVVVDLEVLFEELRDLNTRGVDTSRLQISAGAHLIPPYNRTLDKVTERFLGKRQIGTTGRGIGPTYADKMSRVGIRVQDLFDEKILREKVEGALTLKNQILVKVYNRRAVTIDETVDALLEYADRVRPMVVDTSLVLNQALDRGETVLFEAGQATMLDVDHGTYPFVTSSSATAAGACTGSGIGPTRIDRVIGVIKAYTTRVGEGPFPTELDGDDGEYLRKTGGEYGVTTGRARRTGWYDAVIARYASRVNGLTDFVLTKLDVLTGLEKVPVAVAYDVDGERFDEMPPDQSAFHHATPIYEYLDGWWEDITHARTFDDLPVNAQRYVEHLESVSGTRISAIGVGPDREATIPRYDLLSG
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_SALDC
Sequence: MVTIRLARHGAKKRPFYQVVVTDSRNARNGRFIERVGFFNPIASEKEEGTRLDLDRIAHWVGQGATISDRVAALIKEVKKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: BRN1L_ARATH
Sequence: MAEAKEENREKNEEEESVKLFVGQIPKHMSESQLLTLFQEFAVVDEVNIIKDKITRASRGCCFLLCPSREEADKLVNACHNKKTLPGANSLLQVKYADGELERLEHKLFVGMLPKNVSEAEVQSLFSKYGTIKDLQILRGAQQTSKGCAFLKYETKEQAVSAMESINGKHKMEGSTVPLVVKWADTERERHTRRLQKAQSHIARLGNGDPTNPSLFGALPMGYVPPYNGYGYHQPPGTYGYMLPPIQNQAAFSNMIAQPNQGNNNALQGTSPDSVPPRLARRNFPMPPGNYMGSGYPAMRGHPFPFAYPRGIVSPRPLSSSPGSISPGMSTPLGIGLSSVVQTEGPEGANLFIYNIPREFGDQELAAAFQSFGIVLSAKVFVDKATGVSKCFGFVSYDSQAAAQNAIDMMNGRHLGGKKLKVQLKRDSNNGQPSSNPSLIS
What is the function of this protein?
RNA-binding protein involved in the regulation of flowering time.  Acts as repressor of the activity of SOC1, a transcriptional activator of flowering time.  Binds to the 3'-UTR of SOC1 mRNA in the cytoplasm and participates in SOC1 mRNA decay, mediated by the distal region of the SOC1 3'-UTR (PubMed:23437850).  Acts as positive regulator of salicylic acid (SA)-mediated immunity.  May act on SA signaling-related genes at a post-transcriptional level (PubMed:20636102).
What are the official names of this protein?
RNA-binding protein BRN1, Protein BRUNO-LIKE 1, AtBRN1, Protein RNA-BINDING PROTEIN-DEFENSE RELATED 1, AtRBP-DR1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAPA_SALTY
Sequence: MPFTLGQRWISDTESELGLGTVVAMDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHEGWQLHIDEVKEENGLLVYVGTRLDTEETNVTLREVLLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKFQSEQYRMPYSGLRGQRTNLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYTEAQHDAYNPFETEQLVICSLDFARRNKQRLEHLCDAEWDLLVVDEAHHLVWSTDAPSREYMAIEQLAERVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFEQFVEEQKNYRPVADAVAMLLAGNKLSNDELNRLGDLIGEQDIEPLLQAANSDRDDAQAARDELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTVKLPLPTQYQTAIKVSGIMGARKSPEDRARDMLYPEQIYQEFEGDTGTWWNFDPRVEWLMGYLTSHRSQKVLVICAKATTALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASNLVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRAIYDSAYASLINYLAAPEETDGFDDLIKSCREQHEALKAQLEQGRDRLLEIHSNGGEKAQQLAQSIEEQDDDTNLIAFAMNLFDIVGINQDDRGDNLIVLTPSDHMLVPDFPGLPEDGCTITFERDVALSREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELVYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLSAVNRHTGSKLVNAVQQDVHAILQLGETQIEKSARALIDNARREADEKLSGELSRLEALRAVNPNIRDDELAAIDSNRQQVLESLNQAGWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: HIS4_DICTD
Sequence: MLIIPAIDIYKSKVVRMETGKKEKIILEFDNPIDLAKYWEKKGAKALHLIDLQSAIDGIDENKNIIREIIKNVSIPVEVGGGYRDKEKIEEAINWGVWRVIVSSILEKDLGYLSDLFSKYKEKIIPSIDWYDGRVGIKGWQDFVEWRNIKDKLDLLRVKEVIFTDISRDGTLRGINVENIKTFLRLHDYDIWIAGGISSIEDIIKIKNIWKETERIKGVIIGRALLEGRINWEEAEDIINAG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_PSYWF
Sequence: MNVYYDKDCDLSIIQAKKVAIIGYGSQGHAHALNLQDSGVDVTVGLRKDSGSWKKAENAGLKVAEVAQAVQAADVVMILTPDEFQKSLYEDVIEPNIKEGATLAFAHGFAIHYNQVVPRKDLDVIMVAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGQAKQVALSYASGVGGGRSGIIETTFKDETETDLFGEQAVLCGGAVELVKMGFETLTEAGYAPEMAYFECLHELKLIVDLMYEGGIADMNYSISNNAEYGEYVTGPEVINEQSREAMRNALKRIQSGEYAKMFITEGATNYPSMTARRRNNADHEIEKTGAKLRSMMPWIGGNKIIDKEKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: GSIA_SALCH
Sequence: MPHSDELDSRDVLSVSGLNIAFHHEGQQVDAVRNVSLRLKRGETLAIVGESGSGKSVTALALMRLIEQSGANVRCGEMLLRRRNRQVIELSEQSDAQMRRVRGADIAMIFQEPMTSLNPVFTVGEQIAESIRLHQRASHEEALAEAKRMLDQVRIPESQAILSRYPHQLSGGMRQRVMIAMALSCRPAVLIADEPTTALDVTIQAQILQLIKVLQQEMSMGVIFITHDMGVVADIADRVLVMYQGEAVETGSVEQIFHAPTHPYTQTLLAAVPQLGAMRGHSLPRRFPLISADEPALYESQIEQDTVVEGEPILQVRGLVTRFPLRSGLFNRVTREVHAVENISFDLWPGETLSLVGESGSGKSTTGRALLRLVESRQGEIIFNGQRIDTLSAGKLQPLRRDIQCIFQDPYASLDPRQTVGYSIMEPLRIHGLGQGDAAAKRVAWLLERVGLRPEHAWRYPHEFSGGQRQRICIARALALNPKVIIADEAVSALDVSVRGQIINLLLDLQREMGIAYLFISHDMAVVERISHRVAVMYLGQIVEMGPRRAVFENPQHPYTRKLMAAVPVADPSRHRPRRVLLSDDIPSNIHKRGEETPAVSLQLVGPGHYVARPLQDNALSRL
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Glutathione import ATP-binding protein GsiA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Glutathione importer (TC 3.A.1.5.11) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NFIX_MOUSE
Sequence: MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSSTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQPNGSGQGKVPGSFLLPPPPPVARPVPLPMPDSKTTSTAPDGAALTPPSPSFTTTGASSANRFVGIGPRDG
What is the function of this protein?
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2.  These proteins are individually capable of activating transcription and replication.  Isoform NFIX1 acts as a transcriptional activator while isoform NFIX3 acts as a repressor.
What are the official names of this protein?
Nuclear factor 1 X-type, NF1-X, Nuclear factor 1/X, CCAAT-box-binding transcription factor, CTF, Nuclear factor I/X, NF-I/X, NFI-X, TGGCA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the CTF/NF-I family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL25_BUCAI
Sequence: MLTLQAETRKEKGTGFSRRLRIHNKFPAVLYGVKKTEILLILDHNTTFNLQKKIEFYKENLLLCVQDKKYKVKVQAIQRHSFKSKLLHIDFLYVE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: SPRNG_CHICK
Sequence: MVPCGAVLWRRLLRKRWVLGVVFGLSLVYFLSSTFKQEERTVRDRNLLQVQEHEQPILWKEQFSSGNGSHLSNQCRNSVQGKLLITDELGYICERKDLLVNGCCNVNVPSTKLYSCDSCLPNGCCSVYEYCVSCCLQPSKQHLLERFLNRAAMAFQNLFMAVEDRFELCLAKCRTSSQSVQHENTYRDPIAKYCYGEYPPELLPV
What is the function of this protein?
Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.
What are the official names of this protein?
SREBP regulating gene protein.
What is the protein family that this protein belongs to?
Belongs to the SPRING family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass membrane protein.
Protein: THRB_MOUSE
Sequence: MSHVRGLGLPGCLALAALVSLVHSQHVFLAPQQALSLLQRVRRANSGFLEELRKGNLERECVEEQCSYEEAFEALESPQDTDVFWAKYTVCDSVRKPRETFMDCLEGRCAMDLGVNYLGTVNVTHTGIQCQLWRSRYPHKPEINSTTHPGADLKENFCRNPDSSTTGPWCYTTDPTVRREECSVPVCGQEGRTTVVMTPRSGGSKDNLSPPLGQCLTERGRLYQGNLAVTTLGSPCLPWNSLPAKTLSKYQDFDPEVKLVENFCRNPDWDEEGAWCYVAGQPGDFEYCNLNYCEEAVGEENYDVDESIAGRTTDAEFHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLRAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRKGKYGFYTHVFRLKRWIQKVIDQFG
What is the function of this protein?
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.  Functions in blood homeostasis, inflammation and wound healing (By similarity).
What are the official names of this protein?
Prothrombin, Coagulation factor II.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: HSLV_RALSO
Sequence: MEQYHGTTIVSVRRGNQVALGGDGQVTLGNIVMKGTARKVRTIYDGKVLVGFAGATADAFSLLDRFEAKLQKYQGHLLRAAVDLAKDWRTDRALRHLEAMLIVADRESTLVITGNGDVLDPEGGIAAIGSGGAYAQSAAKALMENTELAPRDVVEKSLRIAGELCIYTNTNFVIETLE
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.