PharMolix/UniProtQA huggingface dataset:
Protein: STK38_BOVIN
Sequence: MAMTGSTPCSSMSSHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKNNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPDTDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK
What is the function of this protein?
Negative regulator of MAP3K1/2 signaling.  Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase 38.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: VPA1_BEFVB
Sequence: MEKGLLSNFWNDFKRWSEDRKVEIVIWWSNLESKVRLGFWIILIILLGILAIRIAIKVYQCVKFTNQGVKKIKRIIKRKRSIKKYRKT
What are the official names of this protein?
Protein alpha-1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL38_CAEEL
Sequence: MPKEIKEIKDFLVKARRKDAKSVKIKKNSNNTKFKVRCASYLYTLVVADKDKAEKLKQSLPPGIQVKELK
What are the official names of this protein?
60S ribosomal protein L38.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL38 family.
Protein: RPOZ_STRCO
Sequence: MSSSISAPEGIINPPIDELLEATDSKYSLVIYAAKRARQINAYYSQLGEGLLEYVGPLVDTHVHEKPLSIALREINAGLLTSEAIEGPAQ
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RL7_AFIC5
Sequence: MADLQKIVDDLSSLTVLEAAELAKLLEEKWGVSAAAAVAVAAAPGAAAGGAPAEEKTEFQVVLAAAGDKKIEVIKEVRAITGLGLKEAKDLVEGAPKPLKEGVAKDEAEKIKAALEKAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RL11_AGRFC
Sequence: MAKKVAGQLKLQVKAGSANPSPPIGPALGQRGINIMEFCKAFNAATQEMEKGMPIPVVITYYQDKSFTFAMKQPPMTYWLKKEAKITSGSKTPGKGAKVGSITKAQVKTIAEAKMKDLNAADIEGAMAMVEGSARAMGLEVVG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RBSD2_RUBXD
Sequence: MKRSGILNQPLSNILASFGHTDLLVVCDAGFPIPRDAQRVDLAIAPDLPDLRTVLSLINEEFITEKVVIAEEMAEFNPPLHGWLQKHFSGVEFERRPHEEMLTQVATSAKAIVRTGAFDPWGNIGLVSGVDVERFFAKEGTVLPDYYRDRAGEA
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase 2.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_LEVBA
Sequence: MPNILKRWVESDRRTLRRLSNLADKVGAYADDYAQLSDDDLKAKTPEFKQRYQDGETLDDLLPEAFAAIREGAKRVLGLYPFHVQIMGGIVLHEGNIAEMKTGEGKTLTATMPVYLNALAGKGVHVVTVNEYLSARDATEMGELYNWMGLTVGLNSAEKSPEEKREAYQADITYSTNGEIGFDYLRDNMVVYKEDMVQRPLNFAIVDEVDSILIDEARTPLIISGQSEGTSALYRRVDRFAKTLHEKDDFKIDLESKTVALTDTGIEKAEKYFNLKNLYDTDNTALTHHMDQALRANFIMLRDKDYVVQDGEVLIVDSFTGRVMDGRRYSDGLHQAIEAKEGVEIQEETKTMANITYQNLFRMYKKLSGMTGTAKTEAEEFREIYNMEVVSVPTNKPVVRVDEPDLLYPTLESKFNAVVKEIKDLHEKGQPMLIGTVAVETSEYLSQRLDEENIPHVVLNAKNHAKEADIIQNAGQRGAVTIATNMAGRGTDIKLGPGVVEIGGLAVIGTERHESRRIDNQLRGRSGRQGDPGMTQFYLSLEDDLMRRFGSDRVKSFLERMNVDGEDAVIRSRMITKQVESAQKRVEGNNYDSRKNVLQYDDVMRQQRDVMYGERNQVINQDKSLKWVLMPMIKRTVDRVVSLHTQGEQSDWDLDTLLDFGISAMVSPDKISLDDLKNKSADEIKAFFMELAEDVYAEKQKQLYDPAQMLEFEKVVLLRVVDSHWTDHIDAMDQLRQSIGLRGYGQLNPLVEYQQDGFRMFEEMISDIDYDATRLFMKSEIRQNITR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: Y4503_MAGSA
Sequence: MNSAPPSRAHQAAQRRGKVAEGLAALWLRLKGYGILAKGLKSGRGSGAGEVDLVARRGDLVAFVEVKSRATLDQAIESLTPFQRQRIERAAAAFLARRPELASCGVRFDMVLVAPWRLPRHIPDAWRID
What are the official names of this protein?
UPF0102 protein amb4503.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: K1A_CRYAD
Sequence: MKFQMIAAVLLIAFCLCVVVTARMELQDVEDMKNGSFQKRRTCIDTIPKSRCTAFQCKNSMKYRLSFCRKTCGTC
What is the function of this protein?
Inhibits voltage-gated potassium channels (Kv) with higher potency for Kv1. 1/KCNA1 and Kv1. 3/KCNA3.
What are the official names of this protein?
Kappa-thalatoxin-Cad2a, Kappa-TATX-Cad2a, Kappa1.3-thalatoxin-Ca1a, Kappa-TATX-Ca1a, Kappa1.3-TLTX-Ca1a, Potassium channel peptide toxin ca-k, CaK.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 1 potassium channel toxin family. Type 1a subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: WRNXO_DROMO
Sequence: MDKYLVKMPIKSTKNVVSEEKISVKEEKPKPKKVVKEQSAIANKRKNLDTPEIVNKENAEVENPPKRRSTRVTRSTRSMADVGTPSPEKEIPEKLPFIKYRGAIKYFTESQEIAASADEVMQWVDQQTHTEIVPMAFDMEWPFSFQTGPGKSSVIQICVDERCCYVYQLSNLKKIPAALVALINHPKVRLHGVNIKADFRKLARDFPEVAAEPLIEKCVDLGVWCNEVCETGGRWSLERLANFIAKKAMDKSKKVRMSKWHVIPLDENQLMYAAIDVYIGQVIYREIEQREQTKLKNEAEFKEQNGENAFKAVKALGETFLTKINEVTL
What is the function of this protein?
Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction.  Essential for the formation of DNA replication focal centers.  Has an important role in maintaining genome stability.
What are the official names of this protein?
3'-5' exonuclease, Werner Syndrome-like exonuclease.
What is the protein family that this protein belongs to?
Belongs to the WRNexo family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LPXC_NOSS1
Sequence: MKQHTLAEAIAHTGVGLHSGVSTHVRILPADAGSGRYFVRVDLPDSPTIPAQVAVVSQTVLSTQLGGGETGVRTVEHLLAALAGMGVDNARIEIDGPEIPLLDGSAQEWVTSIAEVGLVAQAVTNNLASFDIQEPIWIHQDDAFVAAIPASETRFSYGIDFDLPAIGNQWYSWSLTTEPDTSFAQEIAPARTFGLLHQIEYLQKSGLIKGGSLDNALICGPDGWVNPPLRFANEPVRHKILDLVGDLSLLGYFPRAHFLAYKASHNLHIQLAQRILALSN
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: TNT_HUMAN
Sequence: MSLVPGQHCSPSHTRLHLTSPITMGTEPATQNTEFSKGSLIYGVTSPQRGHSQHSEASQGPLSLDKPLQLPPIFLEGEKGESSVQNEQEGEPSLQSPSLELQSPAWPRHAGVAQEPLKVSSSYLSDTQSSESHVSSVQHPRPEEGSHASLSSGYAGDKEGSDISLVGSHRRVRLNRRLNTQAASNQTSQLGSIDPPSSLKSRLTGPAHSTKQTGGKE
What are the official names of this protein?
Protein TNT.
Protein: VSDF_SALDU
Sequence: MLRATKVCIYPTPEQAEHLNAQFGAVRFVYSKSLHIKKHAYQRHGVSLTPRKDIKPLLAVAKKFRKFRKFRKYAWLKEYDSIALQQAVINLDVAFSNCFNPKLKARFPMFKRKHGKLLG
What is the function of this protein?
Expressed but non-essential protein, involved in the virulence of Salmonellas.
What are the official names of this protein?
Virulence protein VsdF.
Protein: ACKA_SHEON
Sequence: MSNKLVLVLNCGSSSLKFAVIDAQTGDDQISGLAECFGLEDSRIKWKINGEKHESSLGAFTAHREAVEFIVNKILAGQPELAAQIQAVGHRIVHGGEKFTRSVIIDEHVIKGIEECSSLAPLHNPAHLIGIRAAMASFPKLPQVAVFDTAFHQSMPERSFIYALPYKLYREHGIRRYGMHGTSHLFVSREAAKVLKKPLAETNVICAHLGNGASVTAVKGGKSVDTSMGLTPLEGLVMGTRCGDIDPSIIYHLVHQLGYTLEEVNNLMNKQSGLLGISELTNDCRGIEEGYADGHKGATLALEIFCYRLAKYIASYTVPLGRLDAVVFTGGIGENSDIIREKVLNMLQIFNFHVDSERNKAARFGKKGIITADNSTVAMVIPTNEEWVIAEDSIKLITK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRK53_ARATH
Sequence: MSMSCKINWLMVLVIIALSNLESSLGRLVFEGSAGLMNGFTTLTNTKKHAYGQAFNDEPFPFKNSVNGNMTSFSFTFFFAIVPEHIDKGSHGIAFVISPTRGIPGASADQYLGIFNDTNDGNSSNHIIAVELDIHKDDEFGDIDDNHVGININGMRSIVSAPAGYYDQNGQFKNLSLISGNLLRVTILYSQEEKQLNVTLSPAEEANVPKWPLLSLNKDLSPYLSKNMYIGFTASTGSVGAIHYMWMWYVFTFIIVPKLDFDIPTFPPYPKAESQVKLIVLVTFLTLALFVALAASALIVFFYKRHKKLLEVLEEWEVECGPHRFSYKELFNATNGFKQLLGEGGFGPVFKGTLSGSNAKIAVKRVSHDSSQGMRELLAEISTIGRLRHPNLVRLLGYCRYKEELYLVYDFLPNGSLDKYLYGTSDQKQLSWSQRFKIIKDVASALSYLHHGWIHVVIHRDIKPANVLIDDKMNASLGDFGLAKVYDQGYDPQTSRVAGTFGYMAPEIMRTGRPTMGTDVYAFGMFMLEVSCDRKLFEPRAESEEAILTNWAINCWENGDIVEAATERIRQDNDKGQLELVLKLGVLCSHEAEEVRPDMATVVKILNGVSELPDNLLDIVRSEKLENWYERYSKVIDPVTTEESIGNLAITEPILPSGRPRLFL
What are the official names of this protein?
Probable L-type lectin-domain containing receptor kinase V.3, Arabidopsis thaliana lectin-receptor kinase c2, AthlecRK-c2, LecRK-V.3.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the leguminous lectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: KIFA3_STRPU
Sequence: MQAEDARYLKRKVKGGSIDVHPTEKALVVNYELEATILGEMGDPMLGERKECQKIIRLRSLNSTTDIAALAREVVEKCKLIHPSKLPEVEQLLYYLQNRKETTQKAGAKKGELTGKLKDPPPYEGTELNEVANINDIEDYIELLYEDNPEKVRGTALILQLARNPDNLEELQSNETVLGALARVLREEWKHSVELATNIVYIFFCFSSFSQFHSIVAHFKIGALVMGVVEHELKKHLSWNEELLKKKKTAEENPASKRDFEKSTKKYHGLLKKQEQLLRVSFYLLLNLSEDPKVELKMKNKNIIRLLIKTLERDNAELLILVVSFLKKLGIYVENKNEMAEQQIIERLAKLVPCDHEDLLNITLRLLLNLSFDTDLRGKMIKLGMLPKFVELLANDNHRLVVLCVLYHVSQDDKAKSMFTYTDCIPMIMKMMLESPTERLEIELVALGINLACNKHNAQLICEGNGLRLLMRRALKFRDPLLLKMIRNISQHDGPSKAQFIEYISDVARIIKESNDEELVVEALGIMANLTIPDLDYEMIINEFGLVPWIKEKLEPGAAEDDLVLEVVMLVGTVATDDSCAAMLAKSGIIQSLIELLNAKQEDDEIVCQIVYVFYQMVFHEATREVIIKLTQAPAYLIDLMHDKNSEIRKVCDNTLDIISEFDEEWARKIKLEKFRWHNSQWLEMVESQQIDDGEGGLMYGDESYSPYIQESDILDRPDLFYGQTGYEDGEMYDGQVTPEYVDEYGNVQNGEYLGRPASAMYGNRYQSEYESLRPGSRVAYLTEDGQPLDEYGNPIEVYAESVDQYGRPVTPTYQYGSQAQQGPGYPY
What is the function of this protein?
Binds to the tail domain of the KRP85/KRP95 heterodimer to form a heterotrimeric kinesin-II complex and may regulate the spindle vesicle targeting of this complex.
What are the official names of this protein?
Kinesin-associated protein 3, SpKAP115.
Protein: HXA4A_TAKRU
Sequence: MTMSSYLINSNYIEPSFPPCDEYQQSGYIPNHGDYYERPKDTGFPHHSEPSYPRSNYTESGYDYGNVPTTGLEDFNDGHHAQPQPVPQSHGPRLSAAPDGGAGAIASKDCSIASEVYPGVAKGKEPVVYPWMKKVHATNITAGYNGGVPKRSRTAYTRQQALELEKEFHFNRYLTRRRRVEIAHTMCLSERQVKIWFQNRRMKWKKEHKLPNTKIRSSSSASSSASGAQQHQQQQQQLQIKSGQQLVPTPSAVSL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A4a.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Deformed subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL24_RHOPS
Sequence: MAAKIRKGDKVIVLSGRDKGRTGEVFEVRPDADVALVRGINMIKRHQKQTQTQEGGIISKEAPIHLSNIAIVGKDGKPTRVGFKVLADGKKVRIAKSSGAEIDG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: KT5BB_XENLA
Sequence: MSAKELCENDDLATSLVLDPYLGFQTHKMNTRFRPIKGRQEELKEVIENFKKNEQLEKTFKNLVAGDWARHYFLHKNKMQETHFKAHVFIYLRMFATSSGFEILPCCRYSSERNGAKIVATKDWKRNDKIELLVGCIAELSEAEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRATGAFKSRVGLNEPGPVINSKYGLRETDKRLNRLKKLGDNGKNSDSQSVSSNTDADTSQEKNTANRKSNGLRKKSKSRTLRRQSMSRIPISSSSTSSKLPHINNSRVPKRLRKTAKPLHSKLKIRCHRKKVEQKKTSKKLDVSNLVLKEPKVVLYKNLAIKKDRESQGAVQVTETTGCLTRHAAREYKLNSFKGAYAHGDTSPCTYITRSSLRTRFNSKDMSEAKLQPNSVDGYRSSHGTVIQLDTGDPLFQSTRKNELLQETSRQSMRFQRNNFNTSRRNSRQNRYITQASKVEDSVSIYNSSSIDNSLPDLGNSHCDLGEGNALIHTSPDYKNIKSSTDEYPLVTSEITKSKKNIRTVKNKKRRRITRYDAQLILENSTGIPKLTLRRRHDSNSSKTNEKENEGMGSSKISIKLSKDHEKDKNSLYVAKLNNGFNSGSGSTSTKLKIQLKRDEENRMAFPNENGMYCSDTLSLLGTRMEVDGYDHYEEESVGESSTEEEEEEEDEFDDEFEDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
What is the function of this protein?
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity.  In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity).  H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression.  Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions.  KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).  Plays a role in myogenesis by regulating the expression of target genes, such as EID3.  Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).  May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
What are the official names of this protein?
Histone-lysine N-methyltransferase KMT5B-B, Lysine-specific methyltransferase 5B-B, Suppressor of variegation 4-20 homolog 1-B, Su(var)4-20 homolog 1-B, Suv4-20h1-B, [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B, [histone H4]-lysine20 N-methyltransferase KMT5B.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with pericentric heterochromatin.
Protein: HSLV_CALS4
Sequence: MFRGTTIVAVRRGDRVSVAGDGQVTFGDSTILKHGAKKIRRLYNGEVIVGFAGSVADAMTLSQKFEEKLEQYGGNLKRAAVELAQEWRKDKILRKLEALLIAADKKDTLLISGTGEVIEPDEDVIGIGSGGNYAMAAALALRYNTDLDTEEIARKALEIASKICVYTNNNITVETL
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_FRATF
Sequence: MSGNTFGKIFTVTTCGESHGDSLAAIIDGCPSNIPLCEAYIQLELDRRKPGQSKFTTQRKEPDEVKIISGVFEGKTTGTPIGLIIKNQDQKSKDYSEIKDKFRPGHADYTYFKKYGIRDYRGGGRSSARETAMRVAAGAIAKKILKHYGIEIYGFCSQIGSLKIDFIDKDFINQNPFFIANKNAVPACEDLIHSIRKQGDSIGAEVTVVATGLEAGLGRPVFDRLDASIAYAMMSINAVKAVSIGDGFDCVAQKGSQHRDEITQQQGFLSNHAGGILGGISTGQDIIAKLAFKPTSSILQPGKSIDVQGNDTTVITKGRHDPCVGIRGVPIAEAMLALVLVDELLITRSYRD
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: SP0A_BACPU
Sequence: LAVLERLRENNEMTKQPSVIMLTAFGQEDVTKKAVDLGASYFILKPFDMENLVGHIRQVSGNGTQVTHRSSSIQNSVLRNKPPEPKRKNLDASITTIIHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRHAIEVAWSRGNIDSISSLFGYTVSMSKAKPTNSEFIA
What is the function of this protein?
May play the central regulatory role in sporulation.  It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress.  Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.  Repressor of abrB, activator of the spoIIa operon.  Binds the DNA sequence 5'-TGNCGAA-3' (0A box) (By similarity).
What are the official names of this protein?
Stage 0 sporulation protein A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYTO_STAA8
Sequence: MQAKLTKNEFIEWLKTSEGKQFNVDLWYGFQCFDYANAGWKVLFGLLLKGLGAKDIPFANNFDGLATVYQNTPDFLAQPGDMVVFGSNYGAGYGHVAWVIEATLDYIIVYEQNWLGGGWTDGIEQPGWGWEKVTRRQHAYDFPMWFIRPNFKSETAPRSVQSPTQAPKKETAKPQPKAVELKIIKDVVKGYDLPKRGSNPKGIVIHNDAGSKGATAEAYRNGLVNAPLSRLEAGIAHSYVSGNTVWQALDESQVGWHTANQIGNKYYYGIEVCQSMGADNATFLKNEQATFQECARLLKKWGLPANRNTIRLHNEFTSTSCPHRSSVLHTGFDPVTRGLLPEDKRLQLKDYFIKQIRAYMDGKIPVATVSNESSASSNTVKPVASAWKRNKYGTYYMEESARFTNGNQPITVRKVGPFLSCPVGYQFQPGGYCDYTEVMLQDGHVWVGYTWEGQRYYLPIRTWNGSAPPNQILGDLWGEIS
What is the function of this protein?
Has weak lytic activity toward S. aureus cells.
What are the official names of this protein?
Probable autolysin LytO.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Protein: R111B_XENLA
Sequence: MKSEVSSDAPKRQENFKGVLLNPETIGASKSFPKEVEMIASKVSNEFNHLCSDTNKQQSDLNSNGTEQDKSLVVHKKRKSQQAGTSYAQSCEVKEYQRLLRLQPKSDEDNDSSFSDCISSPSSSSHFGDSDTMTSDEDKDNPLSSVNSTPRTQSARAQKWPRPHTDSVSSLLMKRPCYQVSSLRRPLHRKRFVKNVSSQRTQKQKERMMLQRKKREVLARQKYALLPSSSSSSENDLSSESSSSSSTEGEDLFVSTGENRQDGTTLPSGGMDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGETYRSRATLRHPRSHWGQNSQSGRTQEQRTRNRVSTVIQPLRQNTTEVVDLTVDEDDPTVVQTTSGRVESQPVSIVSSLTSTSEPASDSMSGLMGSAVPEIPAIPPNTVGTIADDSRTCTSGANADGGPPAMPRLPSCCPQHSPCGGSSQNHVLGHPHSSCFPPHSHHFPHHHHHHHHSSHPGVPLSPSFRDSHCTVERNAAVPPPCGVSSSSGSTYHDPQALPVDLSNNGIRSHGSVGFHSTSAFDPCCPGSSSRSTVYGHQATTSTAQTMAIDGYGSSMVAQAQPPPPTPLSSCRHYMHASYTSLPRPLHHQTSSCPHSNSASQPPPPPPPPPPPPMDYVIAHQVPFISPLPSLTSTHAVPPPPPSHHLSAAAAPLPQHLSTSHQSMSHHISATAPVTQRLHAHEVIQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQGPERSAWEIAIETGVTAATYQTGPLHTHLAHYHPPPRLHHLQIGALPLMVPDMAGYPHIRYISSGLDGRSFRVPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKVSTDWFSQRKLHSKQDGEEATEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIDTQLPTES
What is the function of this protein?
E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity).  Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP.  Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP.  Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By similarity).  The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase arkadia-B, RING finger protein 111-B, RING-type E3 ubiquitin transferase arkadia-B.
What is the protein family that this protein belongs to?
Belongs to the Arkadia family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, PML body. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol.
Protein: THIG_SHESW
Sequence: MLKIADVEFESRLFTGTGKFSNSQVMLEAIRASKSQLVTVAMKRIDFKIGLDDLLTPLRQVGVQLLPNTSGARNAKEAVFAAELAREMLGTRWIKLEIHPDPKYLMPDAIETLEAARILCEKGFIVLPYVHADPVLCRRLEEVGCAAVMPLASPIGSNQGLVTESFLKIIIEQARVPVVIDAGIGAPSQAARAMELGADAVLVNTAIASSASPIVMAECFKEAVQCGRRAFEAGLGRVQTGAVQTSPLTGFLNQ
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLB_CAMJE
Sequence: MKKIVAIFLVFLGSLWAEDPVIDVVNSGVVLPKIIVKDNSNLSDENLKKSFYNIIVNDLKVSSNFEVVANATETSNYIFEYTLNKNGNTLSLNVKIKAGGSDKSEQTYTLNGLEQYPFLAHKSVKASVNALGLAPVDWMDHKILIARNSSSKKSQIIMADYTLTYQKVIVDGGLNLFPKWGNKEQTLFYYTAYDHDKPTLYRYDLNTNKASKILSSGGMVVASDVNVDGSKLLVTMAPKDQPDVYLYDLNTKNLTQLTNYSGIDVNGNFIGSDDSKVVFVSDRLGYPNIFMQDLNSNSAEQVVFHGRNNSAVSTYKDFLVYSSREPNQAGVFNIYLMSINSDYIRQLTANGKNLFPRFSSDGGSIVFIKYLGAQSALGVIRVNANKTFYFPLRVGKIQSIDW
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS12_DESPS
Sequence: MPTINQLVRQGRKKSVKKTNTPALKGCPQKRGVCVRVYTTTPKKPNSALRKVARVRLTNGIEVTSYIPGIGHNLQEHSVVMIRGGRVKDLPGVRYHVIRGTLDTLGVSDRRQGRSKYGAKKPSK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: PERB_ALOVR
Sequence: VEMACPGKVSCLGDKAITVLSENNPLTGTKGEIRMGDGFNVEEEIEKVLEQVGKTTFDVALYASGSWKKPQPLAVMVATLAVMQVRDVVWLSALAMACRLLMDTFAEKYFLQPVLQPSYELFKNAGSNMDGTVTSFDNIYYKTNSWASPLSIRGGYPMHSTSNMGSQIYQDNPVANCLDLSSLDLANR
What are the official names of this protein?
Peroxidase B.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: KLOM_EISFE
Sequence: MPKFTARQNFPDYKSNGHKCMVGRHLTEDMYERLYELRTPNGVSIDKCIQPSVDNTGRIIGLVAGDPESYEVFKELFDAVINEKHGGFGPTDKHPPPDLNANALVGGQFDPKYVKSARIRTGRSVKGFCLPPSISRAERREVERIIVDALAGLEGDLAGVYYPLKKMTPEQEKQLIADHFLFQKPTGHLMVNSGAVRDWPDARGIWHNKDKTFLIWINEEDQVRIIAMQHGGDVKAVFERFSRGLTQIEGLMKKHGHEFAWSERLGYICTCPSNLGTGLRASVHLQLHKLSKHPKFEEIILAFHLQKRGTGGEHTEAVDDVYDISNRARLKKSEREFVQLLIDGVGKLIEYEKLLEAGKSIDDVLPASLKG
What are the official names of this protein?
Lombricine kinase, LK.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.