PharMolix/UniProtQA huggingface dataset:
Protein: S2533_MOUSE
Sequence: MATGTQQKENTLLHLFAGGCGGTVGAIFTCPLEVIKTRLQSSRLALRTVYYPQVHLGTISGAGMVRPTSVTPGLLQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACYSKAKEQFNGIFVPNSNTVHILSAGSAAFVTNTLMNPIWMVKTRMQLERKVRGCKQMNTLQCARRVYQTEGVRGFYRGLTASYAGISETIICFAIYESLKKCLKDAPIVSSTDGAEKSSSGFFGLMAAAAVSKGCASCIAYPHEVIRTRLREEGSKYRSFVQTARLVFREEGYLAFYRGLFAQLIRQIPNTAIVLSTYEFIVYLLGERA
What is the function of this protein?
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria.  Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (By similarity).  May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (By similarity).  Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity).  Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:17596519).  Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (By similarity).
What are the official names of this protein?
Solute carrier family 25 member 33.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EUTC_ECOHS
Sequence: MDQKQIEEIVRSVMASMGQTAPAPSEAKCATTNCAAPVTSESCALDLGSAEAKAWIGVENPHRADVLTELRRSTVARVCTGRAGPRPRTQALLRFLADHSRSKDTVLKEVPEEWVKAQGLLEVRSEISDKNLYLTRPDMGRRLCAEAVEALKAQCVANPDVQVVISDGLSTDAITVNYEEILPPLMAGLKQAGLKVGTPFFVRYGRVKIEDQIGEILGAKVVILLVGERPGLGQSESLSCYAVYSPRMATTVEADRTCISNIHQGGTPPVEAAAVIVDLAKRMLEQKASGINMTR
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: TRUA_ECO24
Sequence: MSDQQQPPVYKIALGIEYDGSRYYGWQRQNEVRSVQEKLEKALSQVANEPITVFCAGRTDAGVHGTGQVVHFETTAQRKDAAWTLGVNANLPGDIAVRWVKAVPDDFHARFSATARRYRYIIYNHRLRPAVLSKGVTHFYEPLDAERMHRAAQCLLGENDFTSFRAVQCQSRTPWRNVMHINVTRHGPYVVVDIKANAFVHHMVRNIVGSLMEVGAHNQPESWIAELLAAKDRTLAAATAKAEGLYLVAVDYPDRYDLPKPPMGPLFLAD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: PCGF1_XENLA
Sequence: MASQGPLVIAMRLRNQLQSVYKMDPLRNEEVVKVKIKELNEHIVCYLCAGYFIDATTITECLHTFCKSCIVKYLQTSKYCPLCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQENEDSRIRDFYHSRGLERVLQPSAVEDSVGDVSQLSLSLAVSQKTSHYYRNDEHVCLCLEKVSSGKDKKKFILQQKYVRCSVRSEIRHLRRVLSHRLSAPLAQVQLLIDNKVLPDHMTMKQLWLMHWYGKPAPLVLLYSVKEKRR
What is the function of this protein?
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
What are the official names of this protein?
Polycomb group RING finger protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: BUCKY_DANRE
Sequence: MEGINNNSQPMGVGQPHHPVNHTRPFFYVQPPSQPYFMYQWPMNPYGHYGFPGPALHFGRPYMAPYQFMQYPGYVIPHAPMQPIDYRRINPHYPSVASYDLRVRHHFQNAGMHRETACSEVQTDPSDSVNKLIDKIESLKACELGSDKGPNNVVSSTPDVVQGEKLTRLNEDSNLEVATKECKEDPVTRPTTYSDSAYDAESSQGRLDECVFSDVLPLDSSSVHEEEEEEEKDVNEEDEPQTVADEICSQNEMSASTTSNVFCSGVQSIADPTECHDLEKLGDEQKQDIPSADAAAVIEPLISLSEDFDLPYQILRLPCNKTTTGLSLEREIDPLVYFDSPSTLLPPQNYLSSIGSAYSYSYYPQVTQERQSVLSPSIDELSSRDEMFSTDVEDLEVVPGHVYVGGGRLAEASDMPVRSRKELPSVDKTCSVCQKTCACCGSTLQDEVGMCKMAEHSHPERDEMSDQDCDYDLEAEVRSNCESPRVSKRKCCSRHALPSCGHHCAKHRHRKLLCEGQESCDLREQARVHPKGECCEEYGALAKADKRIQKGALCRPCIEQQWREGVVSDQENWASCGAKPRSWRQVTGPQDQGRTPLRRSTCKSIHQQRPRSEYNDYDETEFTYCQRGRGSMKKRGSRY
What is the function of this protein?
Prion-like protein required for the formation of Balbiani body (electron-dense aggregates in the oocyte) and germ plasm assembly, and for the establishment of oocyte polarity during early oogenesis (PubMed:18582455, PubMed:19249209).  Mobility and aggregation properties are improved by tudor domain-containing protein tdrd6 through interaction with dimethylated arginines Tri-RG domains (PubMed:30086300).  Establishes oocyte polarity through interactions with RNA-binding proteins rbpms2 and dazl, initiating a positive feedback loop amplification mechanism in the Balbiani body (PubMed:24496621).  Interaction of BUC protein and mRNA with rbpms2 and dazl is required to mediate Balbiani body formation (PubMed:24496621).  Involved in recruitment of germ plasm to embryonic cleavage furrows and dorsoventral patterning through interaction with Kinesin-1/KIF5BA (PubMed:26253407).
What are the official names of this protein?
Bucky ball, buc, Prion-like protein Bucky ball.
What are the subcellular locations of this protein?
Cytoplasm. Cleavage furrow. Note=Localizes to nuage (a peri-nuclear protein-RNA aggregate that associates closely with mitochondria), the Balbiani body during oogenesis, and in the germ plasm upon fertilization (PubMed:19249209, PubMed:30086300). Accumulates at embryonic cleavage furrows (PubMed:26253407).
Protein: MDR1_ASPFU
Sequence: MPAPETGASSREKSLEDLQVATLEKGRSTSSFGADNEKPHDHHSLSDTIMAPPDGKQKDHGKAVDLNDDSLFAHLQEHEKEVLKRQLDAPSVKVSFFTLYRYASRKDILIILVSAICAIAAGAALPLFTILFGSLASAFQGISLGTMPYHEFYHKLTKNVLYFVYLGIAEFVTVYVSTVGFIYTGEHLTQKIRENYLEAILRQNMAYFDKLGAGEVTTRITADTNLIQDAISEKVGLTLTAFATFVTAFIVAYVKYWKLALICTSTIVALVMVMGGGSRFIVKYSKKSIESYGAGGTVAEEVISSIRNATAFGTQDKLAKQYETHLAEAEKWGVKQQVILGMMIGGMFGIMFSNYGLGFWMGSRFVVGKEVNVGQVLTVLMSILIGSFSLGNVAPNGQAFTNGVAAAAKIYSTIDRRSPLDPYSDEGKVLDHFEGNIEFRNVKHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYLPVGGQVLLDGHDIQTLNLRWLRQQISLVSQEPVLFSTTIFRNIEHGLIGTKFEHESKDKIRELVENAARMANAHDFIMALPEGYDTNVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAALDKAAEGRTTIVIAHRLSTIKTAHNIVAMVGGKIAEQGTHDELVDRKGTYYKLVEAQRINEEKEAEALEADADMDADDFGQEGVTRIKTAVSSSNSLDAVDEKARLEMKRTGTQKSVSSAVLSKKVPEQFEKYSLWTLVKFIGAFNRPELGYMLIGLTFSFLAGGGQPTQAFLYAKAISTLSLPESMFHKLRHDANFWSLMFFVVGIAQFISLSINGTAFAICSERLIRRARSQAFRSILRQDISFFDREENSTGALTSFLSTETKNLSGVSGVTLGTIIMTSTTLGAAMIIALAIGWKLALVCISVVPILLACGFLRFYMLAQFQQRSKSAYEGSASYACEATSAIRTVASLTREQDVWGVYHDQLQKQGRKSLISVLRSSLLYASSQALVFFCVALGFWYGGTLLGHHEYSIFRFFVCFSEILFGAQSAGTVFSFAPDMGKAKNAAAQFKKLFDSKPTIDIWSDEGEKLESMEGEIEFRDVHFRYPTRPEQPVLRGLNLSVKPGQYIALVGPSGCGKSTTIALLERFYDALAGGVFVDGKDITKLNVNSYRSFLSLVSQEPTLYQGTIKENILLGVDKDDVSEETLIKVCKDANIYDFVMSLPEGFDTVVGSKGGMLSGGQKQRVAIARALLRDPKVLLLDEATSALDSESEKVVQAALDAAARGRTTIAVAHRLSTIQNADIIYVFDQGKIVESGTHHELIRNKGRYYELVNLQSLGKTH
What is the function of this protein?
Pleiotropic ABC efflux transporter that may be involved in A. fumigatus adaptation to azoles such as vorizonazole.
What are the official names of this protein?
ABC multidrug transporter mdr1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARGB_AZOVD
Sequence: MTLSRDAAIQVAQVLSEALPYIRRFVGKTLVIKYGGNAMESDELKTGFARDIVLMKAVGIHPVVVHGGGPQIGDLLKRLSIESRFVDGMRVTDAQTMDVVEMVLGGQVNKDIVNLINRHGGSAIGLTGKDAGLIRAKKLKVTRQTPEMTQPEIIDIGQVGEVESVNTELLNMLVQGDFIPVIAPIGVGADGESYNINADLVAGKVAEALKAEKLMLLTNIAGLMDKEGRVLTGLSTEQVDALIADGTIYGGMLPKIRCALDAVQGGVTSAHIIDGRVPNAVLLEIFTDTGVGTLITNRQG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_GEOUR
Sequence: MKEGIHPNYTEVTVKCLCGNTFQTRSTKPEISTEICSACHPFFTGKQKLIDTAGRVERFKRRYGM
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: IMA7_MOUSE
Sequence: METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPGVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSLCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL
What is the function of this protein?
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1.  Binds specifically and directly to substrates containing either a simple or bipartite NLS motif.  Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
What are the official names of this protein?
Importin subunit alpha-7, Importin alpha-S2, Karyopherin subunit alpha-6.
What is the protein family that this protein belongs to?
Belongs to the importin alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLF23_ARATH
Sequence: MRGLSRNSGAAAIFAILLILAVHNWSVAVSSQSTEFAGDFPPFETECRGTIAECSVSAALGDGGDLFYGGGEMGEEFEMDSEINRRILATRRYISYGALRRNTIPCSRRGASYYNCRRGAQANPYSRGCSAITRCRRS
What is the function of this protein?
Cell signaling peptide that may regulate plant stress, growth, and development.  Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).  Regulates negatively brassinolide (BL)-mediated signaling pathway (e. g.  BL-induced hypocotyl elongation and branching limitation) (PubMed:19473327).
What are the official names of this protein?
Rapid alkalinization factor 23, AtRALF23, Protein RALF-like 23.
What is the protein family that this protein belongs to?
Belongs to the plant rapid alkalinization factor (RALF) family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRUA_METC4
Sequence: MPRYKLVIEYDGAPFRGWQRQADDPTVQAAIETAVTRFSGETARLTCAGRTDAGVHAIHQVAHLDLAKDWRTDTVRDALNAHLRPQPVSILSAEVVPQEFDARHSAIRRHYRYRILNRRSPAALTRAHVWQVPWPLDAELMHRAAQRLLGHHDFSAFRAAECQAKSPMRTLEQLDVTRERMGLFEEIVIATSARSFLHHQVRAMAGTLMLAGCKRLSADDVAEILATGAKHRCGPLAPACGLTFVGVDYL
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: SYDND_CORU7
Sequence: MLRTHLAGELRPGDIDSEVTLTGWVGRRRDHGGVIFIDLRDRSGVAQVVFRESEVAERAHALRSEYCVRVRGRVEARPEGSENPNLPSGAVEVNVSELEVLNESAALPFQIDDPSSAGEVGEETRLKYRYLDLRRASQGDALRLRSKANAAARKVLERHDFTEIETPTLTRSTPEGARDFLVPARLKPGTFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDVEMSFVDQEDVIALAEEILTEVWSTAGYEVQTPFPRMTYADAMRLYGSDKPDLRFDIQITECTEFFKDTTFRVFQNEYVGAVVMDGGASQPRRQLDAWQEWAKQRGAKGLAYILVGEDGELSGPVAKNITDDERAGIADHVGAKPGDCIFFAAGDTKSSRALLGAARGEIAQKLGLIDDSKWAFTWVVDAPMFEPAADARAEGDVALGNSAWTAVHHAFTSPKPEFLDSFDQDPGSALAYAYDIVCNGNEIGGGSIRIHQRDVQERVFQVMGISQEEAREKFGFLLDAFAFGAPPHGGIAFGWDRIVSLLGGFDSIRDVIAFPKSGGGVDPLTDAPSEITPEQRKESGIDAKPKRAAAAQAGAAKASSK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_PARD8
Sequence: MLQPKKTKFRRQQKGRMKGEAQRGNQLAFGSFGIKSLENKWITGRQIEAARIAVTRYMQRQGQVWVRIFPDKPITKKPAEVRMGKGKGNPEGFVAPVTPGRLIFEIEGVPFDIAKEALRLAAQKLPVTTKFVVRRDYDMQNQNA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RL7_MYXXD
Sequence: MADLNAIVDQLSSLTVLEAAELVKQLESKWGVSAAAVAVAAGPAAAAAPVEEKTEFTVVLANAGANKINVIKEIRAITGLGLKEAKDLVEGAPKNVKEGVNKDDAKKIKDQLTAAGATVDIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: PANB_TRIL1
Sequence: MRKKITIPEILLMKQEGRKVTVLTAYDYPTARLVDAGGVDAILVGDSAGVVFSGHENTLPVTMDEMLYHVKAVVRARPKALVVADMPFMACQSGEIEALKNCGRMLQEGGAEAVKIEGGSNMAPIIRAVTEMDIPVMGHVGLTPQSVHRMGGYKVQGRKDQAERILEDAHAVQEAGAFAVVLEGIPAKLAARITEMLEIPTIGIGAGPACDGQVLVIHDILGLCEKYSPKFVKRYADLAPLITEAARQYVSEVKDGTFPTEEHSFS
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIRL_STUST
Sequence: MNSCLNELQAMQLRRLLETGLPLAARPYQRLAEQIGSVEEHVLQQIQRWQEEGLFRRVGLVLKHRALGFRANAMLVMDIPDAQVDEIGRRLGQAAGVNLCYQRPRRLPQWPYNLFCMVHGREREQVCQLIERLLADNGLSEVPHQLLFSTRAFKQCGGRFAPPLREVVNG
What is the function of this protein?
Involved in heme d1 biosynthesis.  Catalyzes the decarboxylation of siroheme into didecarboxysiroheme.
What are the official names of this protein?
Siroheme decarboxylase NirL subunit.
What is the protein family that this protein belongs to?
Belongs to the Ahb/Nir family.
Protein: GSA_BURP6
Sequence: MSNNQTLFERAQRTIPGGVNSPVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQHVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADVAKHTTVLEYNNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVMCGFRVALGGAQQHYGITPDLTCLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGFHDALADKTRRLADSLAAEARAAGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDAGVYFAPSAYEAGFVSSAHDDATLDATLDAARRAFAALRA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTUC_ECOSE
Sequence: MLTLARQQQRQNIRWLLCLSVLMLLALLLSLCAGEQWISPGDWFTPRGELFVWQIRLPRTLAVLLVGAALAISGAVMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPNWALGLCAIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSALMTWAIYFSTSVDLRQLMYWMMGGFGGVDWRQSWLMLALIPVLLWICCQSRPMNMLALGEISARQLGLPLWFWRNVLVAATGWMVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASALLLADVVARLALAAAELPIGVVTATLGAPVFIWLLLKAGR
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Involved in the translocation of the substrate across the membrane.
What are the official names of this protein?
Vitamin B12 import system permease protein BtuC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y465_YERE8
Sequence: MNNPDDLIVITRFLRQQHVLTLCAGSGMDMWCANCFYVFDEAKMALYLMTEKHTRHGELMQINPQVVGTIATQPRTVALIKGIQYRGEITELKDDAELIARQHYCRRFPVAKVVSAPLWQLNLLEIKMTNNTLDFGKKLYWSRLESQ
What are the official names of this protein?
UPF0306 protein YE0465.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: FENR_AZOVI
Sequence: MSNLNVERVLSVHHWNDTLFSFKTTRNPSLRFENGQFVMIGLEVDGRPLMRAYSIASPNYEEHLEFFSIKVQNGPLTSRLQHLKEGDELMVSRKPTGTLVTSDLLPGKHLYMLSTGTGLAPFMSLIQDPEVYERFEKVVLIHGVRQVNELAYQQFITEHLPQSEYFGEAVKEKLIYYPTVTRESFHNQGRLTDLMRSGKLFEDIGLPPINPQDDRAMICGSPSMLDESCEVLDGFGLKISPRMGEPGDYLIERAFVEK
What is the function of this protein?
Transports electrons between ferredoxin and NADPH.
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, NADPH:ferredoxin reductase, Protein X.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 1 family.
Protein: MTND3_CAEBR
Sequence: MVQIWQMEPYPCGDPRLPHHLFPPKKITPDELSKRTGTLYWKLDTLDQVALAKRLTTLKLEHNFKKEDIFTLDAETTANFDDKIEELFEESSVPFEQARMIIEGSAYYDVEDKNGQWVRIFCEYGDLILIPSNTCFRFTTTPKNFVKMRRFYKEEEGN
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase 3, Acireductone dioxygenase (Fe(2+)-requiring) 3, ARD' 3, Fe-ARD 3, Acireductone dioxygenase (Ni(2+)-requiring) 3, ARD 3, Ni-ARD 3.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: METK_PSEA6
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILKQDPKARVACETYVKTGMVMVGGEVTTNAWVDIEELTRNTVREIGYTHSDMGFDADSCAVLNAIGKQSPDINQGVDRTRPEDQGAGDQGLMFGYASDETDVLMPAPVTYAHRLVKRQAEIRKSGQLDWLRPDAKSQVTFVYEDNVPVGIDAVVLSTQHCDSVTTEQLREAVMEEIIKPVLPAKWLTAQTKYFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLAKRCEIQISYAIGVAEPTSINVETFGTGQVSDEVLTTLVREHFELRPYGLIKMLDLERPIYQATAAYGHFGREEFPWEKTDKADALRAAANL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPA_CITFR
Sequence: DKGFGFITPDDGSKDVFVHFSAIQNDGYKSLDEGQKVSFTIESGAK
What are the official names of this protein?
Major cold shock protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_CHLT3
Sequence: MPDSFSKIPIPVILGATGSGKTATAIALAELLDAEIVSADSRQIYKELDIGTAKPTAEERRAVKHHFIDELEVTEPYNAAQFATDAATRIEAIFSTGKNVVVAGGSTLYLQGLLQGFSKLPENSPEVREKLYADLAEHGATALYEKLKAADPEHAATLDPTKTQRLIRSLEILEVSSKTVSELKAAEILKPGFHFVPFGLALPRERLYEKINLRTDEMFKNGFLEEATRLFEKYAPVMRQGVKINALATVGYNELFSFLEGKLSLDEAKNLVKQHTRNYAKRQLTFFRNKFSADWINFAETDENALETAKQILMKLKKANPFC
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: SECR_SHEEP
Sequence: HSDGTFTSELSRLRDSARLQRLLQGLV
What is the function of this protein?
Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis.  Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells.  Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content.  Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity).  Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid.  In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation.  Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation.  Also able to stimulate lipolysis in white adipocytes (By similarity).  Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity).  Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity).
What are the official names of this protein?
Secretin.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.