PharMolix/UniProtQA huggingface dataset:
Protein: CXB2_HUMAN
Sequence: MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV
What is the function of this protein?
Structural component of gap junctions (PubMed:17551008, PubMed:19340074, PubMed:21094651, PubMed:26753910, PubMed:16849369, PubMed:19384972).  Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells.  They are formed by the docking of two hexameric hemichannels, one from each cell membrane (PubMed:17551008, PubMed:19340074, PubMed:21094651, PubMed:26753910).  Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:21094651, PubMed:16849369, PubMed:19384972).
What are the official names of this protein?
Gap junction beta-2 protein, Connexin-26, Cx26.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Beta-type (group I) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Note=Colocalizes with GJB4 at gap junction plaques in the cochlea.
Protein: TRMB_MALP2
Sequence: MGRLRKDYQDELRLFNSQEFYVLNPNQYKGLWNQQIFKNNNNIEIEVGTGKGTFIFNKALKNKNINFIAIDKYPTILAKLLNKLESCSETLTNIKIISIDAKNINDIFDKSEISKIYLNFVDPWPKTHHEKFRLTNSFYLNLFLPLLKQDGLIEFKTDNLNFFNYSLSVARENSFCLTFATKNLYSSAHAKDNIQTEYERKWSNRGYKINKLVIKNNISQ
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: MURA_CAMJE
Sequence: MTYLEIEGTNHLSGNVTISGAKNAALPLIVSSILAKNEVKINNVPNVADIKTLISLLENLGAKVNFQNNSALLNTNTLNQTIAKYDIVRKMRASILTLGPLLARFGHCEVSLPGGCAIGQRPIDLHLLALEKMGANIQIKQGYVVASGNLKGNEILFDKITVTGSENIIMAAALAKGKTKLLNVAKEPEVVQLCEVLKDAGLEIKGIGTDELEIYGSDGELLEFKEFSVIPDRIEAGTYLCAGAITNSKITLDKVNATHLSAVLAKLHQMGFETLITEDSITLLPAKEIKPVEIMTSEYPGFPTDMQAQFMALALKANGTSIIDERLFENRFMHVSELLRMGADIKLNGHIATIVGGKELNAADVMATDLRASSALILAALAAKGTSKVHRIYHLDRGYENLEEKFKDLGAKITRLEE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_MYCUA
Sequence: MTFRGDTAVVVLAAGAGTRMRSDTPKVLHTLAGRSMLSHSLHAMAKLAPQHLVVVLGHCHERISPLVDELAESLGRTINVTLQDRPLGTGDAVRCGLSALPADYSGIVVVTAGDTPLLDAETVADLIETHSATSSAVTVLTTTLSDPHGYGRILRTQDNAVMAIVEQTDATPSQREIREVNAGVYAFEITALQSALSRLSSDNAQQELYLPDVIAILRRDGQTVSARHIDDSALVAGVNDRVQLAQLGAELNRRIVAAHQMAGVTVIDPATTWIDVDAAIGRDTVIQPGTQLLGHTQIGDRCEIGPDTTLTDVTVGDNASVVRTHGSSSSIGAAAAVGPFTYLRPGTVLGTGGKLGAFVETKNSTIGAGTKVPHLTYVGDADIGDDSNIGAGSVFVNYDGMTKNRATIGSHVRSGAGTRFVAPVNVGDGAYTGAGTVIRDDVPPGALAVSGGPQRNIEDWVQQKRPGTPSAEAARKASAEQSTPPPDADHPP
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOL_BPT3
Sequence: MNIIENIEKNDFSEIELAAIPFNTLADHYGSALAKEQLALEHESYELGERRFLKMLERQAKAGEIADNAAAKPLLATLLPKLTTRIVEWLEEYASKKGRKPSAYAPLQLLKPEASAFITLKVILASLTSTNMTTIQAAAGMLGKAIEDEARFGRIRDLEAKHFKKHVEEQLNKRHGQVYKKAFMQVVEADMIGRGLLGGEAWSSWDKETTMHVGIRLIEMLIESTGLVELQRHNAGNAGSDHEALQLAQEYVDVLAKRAGALAGISPMFQPCVVPPKPWVAITGGGYWANGRRPLALVRTHSKKGLMRYEDVYMPEVYKAVNLAQNTAWKINKKVLAVVNEIVNWKNCPVADIPSLERQELPPKPDDIDTNEAALKEWKKAAAGIYRLDKARVSRRISLEFMLEQANKFASKKAIWFPYNMDWRGRVYAVPMFNPQGNDMTKGLLTLAKGKPIGEEGFYWLKIHGANCAGVDKVPFPERIAFIEKHVDDILACAKDPINNTWWAEQDSPFCFLAFCFEYAGVTHHGLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAQKVNEILKQDAINGTPNEMITVTDKDTGEISEKLKLGTSTLAQQWLAYGVTRSVTKRSVMTLAYGSKEFGFRQQVLDDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWDAVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTKEILRHRCAVHWTTPDGFPVWQEYRKPLQKRLDMIFLGQFRLQPTINTLKDSGIDAHKQESGIAPNFVHSQDGSHLRMTVVYAHEKYGIESFALIHDSFGTIPADAGKLFKAVRETMVITYENNDVLADFYSQFADQLHETQLDKMPPLPKKGNLNLQDILKSDFAFA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the phage and mitochondrial RNA polymerase family.
Protein: SYL_BURP1
Sequence: MHERYVPADVEAAAQSDWRAADAYRSKEDANRKKFYCVSMLPYPSGKLHMGHVRNYTINDVMYRYLRMNGYNTLMPMGWDAFGMPAENAAMANGVPPAQWTYENIAYMKKQMQSMGLAIDWSREVTTCKPDYYKWNQWLFLKMLEKGVAYKKTGTVNWDPVDQTVLANEQVIDGRGWRSGALVEKREIPMYYMRITQYADELLNDLDGLGWPERVKVMQHNWIGKSFGVNFGFPYELDGEKKLLRVFTTRADTIMGVTFCAIAAEHPLAARLARDKPALQAFIDECKRGGVAEADIATMEKKGVATGFSVSHPLTGEPVEVWIGNYVLMSYGEGAVMGVPAHDERDFAFAKKYGLPIRQVIAVEGETYSTDAWQEWYGDKTRAVCVNSGKYDGLAHDAAVDAIAAELKAGGLGDKQITYRLRDWGISRQRYWGTPIPIIHCPSCGDVPVPEQDLPVVLPEDLVPDGTGNPLAKSDAFLNCTCPKCGAAAKRETDTMDTFVDSAWYFSRYAAPDAQTMVDARTDYWMPMDQYIGGIEHAILHLLYSRFWAKVMRDLGLVAFGEPAKNLLTQGMVLNETFYREDAAGKKTWYNPADVTVSFDDKGRPVGAVLKSDGQPVELGGIEKMSKSKNNGVDPQMLIDHYGADTARLFTMFAAPPEQQLEWSGAGVDGASRFLRRVWAFGFANREALAVRAPFDAAQLAEADKTLRREIHGVLKQADFDYQRLQYNTVVSAAMKMLNAIEGAKGSTPAVLRETYGVLLRVLYPVVPHVTFELWKALGYADEFGPLLDAPWPKVDEAALEQAEIELVLQVNGKVRGALKVAKDASREAIEAAAVADEMFAKFAEGRPAKKIIVVPGRLVNVVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDIAS_HUMAN
Sequence: MNRRRKFLLASVLALQNSSFIYPSCQKCFSRIILVSKRSNCPKCGSTGESGNANYRYKLSLKVAESNKLFVITVFGSCLDTFFGLTATGLHRYIQDPNKIPETLDNDTTQNLLTKAVETCFVGQSFIFGVTNFENQPGQGSDASNFLQQCSDHKRKAKALVACQIVLPDPGIAGFTVIDYFHQLLQTFNFRKLQCDSQAPNNHLLALDHSNSDLSSIYTSDSTSDFFKSCSKDTFSKFWQPSLEFTCIVSQLTDNDDFSASEQSKAFGTLQQNRKSISIAEATGSSSCHDPIQDSWSLVSYMDKKSTAEKLGKELGLQAKELSAVHSSHHEIGVNDSNLFSLEMREPLESSNTKSFHSAVEIKNRSQHELPCFQHHGIDTPTSLQKRSACCPPSLLRLEETASSSQDGDPQIWDDLPFSESLNKFLAVLESEIAVTQADVSSRKHHVDNDIDKFHADHSRLSVTPQRTTGALHTPPIALRSSQVIVKANCSKDDFLFNCKGNLSPSVEKESQPDNKVEAVSVNHNGRDMSEYFLPNPYLSALSSSSKDLETIVTLKKTIRISPHRESDHSSLNNKYLNGCGEISVSEMNEKLTTLCYRKYNDVSDLCKLENKQYCRWSKNQDDSFTICRKLTYPLETLCNSPNRSTNTLKEMPWGHINNNVTQSYSIGYEGSYDASADLFDDIAKEMDIATEITKKSQDILLKWGTSLAESHPSESDFSLRSLSEDFIQPSQKLSLQSLSDSRHSRTCSPTPHFQSDSEYNFENSQDFVPCSQSTPISGFHQTRIHGINRAFKKPVFYSDLDGNYEKIRIFPENDKQQASPSCPKNIKTPSQKIRSPIVSGVSQPDVFNHYPFAECHETDSDEWVPPTTQKIFPSDMLGFQGIGLGKCLAAYHFPDQQELPRKKLKHIRQGTNKGLIKKKLKNMLAAVVTKKKTHKYNCKSSGWISKCPDIQVLAAPQLHPILGPDSCSEVKCCLPFSEKGPPSVCETRSAWSPELFS
What is the function of this protein?
May be an anti-apoptotic protein involved in DNA repair or cell survival.
What are the official names of this protein?
DNA damage-induced apoptosis suppressor protein, Nitric oxide-inducible gene protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Accumulates in the nucleus in response to stress.
Protein: VP41_NPVOP
Sequence: MNERDGFYLTPSQSGHPFAPTSATLTSSQSGYPTAVSTTLSRADSRSNTALAKAGDVGEAIWYNKCTDYVHKIIRYYRCNDMSELTPLMIQFINTIRDMCIDSNPVSANIIKRAQSDDDIVRHLIGLQKELRQNSVAEAIGSDFNIFQPSFVLNSLPAYAQKFYNGGANTLGKDALNEAAKQLSLAVQYMVSEAVTCSIPIPLPFDQQLANNYVTLLLKRATLPDNMQEAVKSRSFVHINMINDLINAVIEDLFAGGGTYYYYVLNEKNRARVVGLKENVGFLAPISASADIFNYIAQLATQQGKRPDMFENAAFLTAAAHAINSPAAHLTQSACQKSLSQLAAQCETLTRFVFMIMNHNTVPTTRG
What are the official names of this protein?
Structural glycoprotein gp41.
What is the protein family that this protein belongs to?
Belongs to the baculoviridae gp41 family.
What are the subcellular locations of this protein?
Virion. Note=Region spanning the nucleocapsid and envelope.
Protein: POTA_LISMO
Sequence: MIVTETIIRFENVTKQFDNDPPVLDNVSFEIEKGKFYTLLGPSGCGKTTILRLIAGFLEASKGQIYLGDKVINQIPANKRPVNTVFQDYALFPHLNVYENVAFGLRIKKLKKEAIDEKVKEALRFVNLKGYEKREISEMSGGQRQRVAIARAIVNEPEVILLDEPLSALDLKLRTEMQYELRDLQKRLGITFIFVTHDQEEALAMSDEIFVLNKGEIQQSGTPIDIYDEPINKFVADFIGESNIVNGKMIQDFEVEFVERRFECVDQGFRPNEVVEVVIRPEDLEITSAEKGQLQVTVDWMLFRGVHYEVGCIDIDGNEWLVHTTRKVRVGDKIGLAFEPEAIHVMRLGETEEEFDKRLDSYDEVQ
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SUB7_TRIEQ
Sequence: MGFITKAIPLALAAASVINGAEILETRAGVQTLADKYIVVMNDGMSDKDFDSHRSWVNRTHRRRLIRRGAKAMGGMKYTYNFPTGLKGYSGHFDEQMIKEISKRADVKYIERDARVQINAIEQQDNVPSWGLARVGSREPGGTTYYYDSTAGEGTTAYIIDTGTDIQHEEFDGGRATWGENFADDMDMDCNGHGTHVSGTVGGRTFGVAKKSNIVAVKVLDCNGSGSNSGVIMGMQWATEDAQSKGADKAVVNMSLGGAFSQTSNDAAKAIAEGGVFLAVAAGNDNVDAAEASPASEPSICTVAASTEQDGKADFSNFGQVVDVYAPGDGITSAKPGGGSQVLSGTSMASPHVAGLAAYLIGLGKGGGPQLCDTIKQMAIDVIQNPGSSTTSKLINNGSGM
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 7.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YTFE_SALPC
Sequence: MAYRDQPLGELALSIPRASALFRQYDMDYCCGGKQTLARAAARHDVDIDIIEAQLAQLAEQPIEKDWRAVPLADIIDHIVVRYHDRHREQLPELILQATKVERVHADKPNVPRGLTKYLTALHEELSSHMMKEEQILFPMIKQGMGRQATGPISVMESEHDEAGELVDVIKHVTQNVTPPPEACTTWKAMYNGINEMIDDLMEHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FGD_MYCGI
Sequence: MAELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTTRLQLGTSVLTPTFRYNPAVIAQAFATMGCLYPDRIFLGVGTGEALNEIATGYEGEWPEFKERYARLRESVRLMRELWLGDRVDFEGEYYKTKGASIYDVPEGGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELYKEKLIPAMREGAEAAGKNPDDVDRMIEIKISYDTDPELALENTRFWAPLSLTAEQKHSIDDPMEMEKAADELPIEQVAKRWIVASDPDEAVAKVADYVDYGLNHLVFHAPGHDQRRFLELFQRDLEPRLRKLG
What is the function of this protein?
Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone.  Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.
What are the official names of this protein?
F420-dependent glucose-6-phosphate dehydrogenase, FGD, G6PD.
What is the protein family that this protein belongs to?
Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family.
Protein: RPOB_LIRTU
Sequence: MLRDGNEGMSTIPGFSQIQFEGFCRFIDQGLTEELHKFPKIEDTDQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVPAGLIWKTGRDMQEQTVFIGNIPLMNSLGTSIVNGIYRIVINQILQSPGIYYRSELDHNGISVYTGTIISDWGGRSELEIDRKARIWARVSRKQKISILVLSSAMGSNLREILDNVCYPEIFLSFPNDKEKKKIGSRENAILEFYQQFACVGGDPVFSESLCKELQKKFFQQRCELGRIGRRNMNRRLNLDIPQNNTFLLPRDVLAAADHLIGMKFGMGTLDDMNHLKNKRIRSVADLLQDQFGLALVRLENAVRGTICGAIRHKLIPTPQNLVTSTPLTTTYESFFGLHPLSQVLDRTNPLTQIVHGRKSSYLGPGGLTGRTASFRIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARIGHWGSIESPFYEISERSKEVQMVYLSPSRDEYYMVAAGNSLALNWGIQEEQVVPARYRQEFLTIAWEQIHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLECQAALDSGVSAIAEHEGKIVYTDTDKIVLSGNGDTISIPLVMYQRSNKNTCMHQKPQVRRGKCIKKGQILADGAATVGGELALGKNVLVAYMPWEGYNSEDAVLISERLVYGDIYTSFHIRKYEIQTHVTSQGPERITNEIPHLEAHLLRNLDKNGIVMLGSWIETGDILVGKLTPQTAKESSYAPEDRLLRAILGIQVSTAKETCLKLPIGGRGRVIDVRWIQKKGGSSYNPEMIRVYISQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPVDMVFNPLGVPSRMNVGQIFECSLGLAGDLLDRHYRIAPFDERYEQEASRKLVFSELYSASKQTANPWVFEPECPGKSRIFDGRTGDPFEQPVIIGKSYILKLIHQVDDKIHGRSSGHYALVTQQPLRGRAKQGGQRVGEMEVWALEGFGVAHISQEMLTYKSDHIRARQEVLGTTIIGGTIPNPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GGGPS_METTP
Sequence: MLRKRVEIGPVESGLWNAVETDGAAHLTLIDPASQDPERAVQMARSAADAGTTALMVGGSVGATGSALDRTVRAIKDSVDLPVILFPSSAAGLCDNADAVFFMSLLNSRSTSYLIENQALGAPIVSRYGIEAIPMGYIVVEPGGTVGWVGDAKLVPRRKPDIAAAYALAGRYLGMRLIYLEAGSGAESPVPTSMVSAVRDAIGDTLLVVGGGIRDAEAARKLVSAGADLIVTGTGVEESGDVFRFVKDIVTAIHV
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).  This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Geranylgeranylglyceryl phosphate synthase, GGGP synthase, GGGPS, (S)-3-O-geranylgeranylglyceryl phosphate synthase, Phosphoglycerol geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATB2_METHJ
Sequence: MQHGSLITVEYQTVNYVSGPLIFVERPKEISFGETAQIILPDGEARTGQILDISEDIAVVQVFEGTRGIDSHVTTVRFTGQSPLLDVSYDMLGRVLDGVGRPRDGGPEIIPEARLDIAGMPINPYSRDKPAEFIQTGISAIDALNTLVRGQKLPIFSGAGLPANQLAAQIAKQAKVLGEGENFAVVFAAMGITYKEASFFMKEFEESGALERVVFFLNLADDPTIERIATPRCALTAAEFLAYTHNLHVLVILTDMTNYCDALREISTAREEIPGRRGYPGYMYTDLATIYERAGRIKGCTGSITQIPILTMPDDDITHPVPDLTGYITEGQIVLSRDLFRKGINPPIDALPCLSRLMNLGIGPGKTREDHRNVADQLYASYAYGRDLRRLVAIVGEEALSELDRNYLKFADHFEKRFISQGNVERSIETTLQVAWELFSLLPDEELKRIKEEYIDKYRTLIISGG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain 2, V-ATPase subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: SOSSC_DANRE
Sequence: MAANPPGQGFQNKNRVAILAELDKEKRRLIQSQTLNNPGASIPLSRPAVNKEFRDQAEQQHIAAQQKAALQHAHAHSSGFFITQDSSFGNLILPVLPRLDPLE
What is the function of this protein?
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint.  The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability.  Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity).
What are the official names of this protein?
SOSS complex subunit C, INTS3- and NABP-interacting protein, Sensor of single-strand DNA complex subunit C, Sensor of ssDNA subunit C, SOSS-C, Single-stranded DNA-binding protein-interacting protein 1, SSB-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the SOSS-C family.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to nuclear foci following DNA damage.
Protein: NEF_HV1MP
Sequence: MGGKWSKSSIVGWPNVRERMRAAEGVGKVSQDLDKHGAITSSNTRATNADLAWLEAQEEEVGFPVRPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIYSKKRQEILDLWVYHTQGYFPDWQNYTPGPGIRYPLTLGWCFKLVPVDPEEIEKANEGENNCLLHPISLHGMEDEDREVLRWKFDSSLALRHVARERHPEFYQD
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: SYGA_VIBVY
Sequence: MQKYDIKTFQGMILALQDYWAQNGCTIVQPLDMEVGAGTSHPMTCLRALGPEPMSTAYVQPSRRPTDGRYGENPNRLQHYYQFQVALKPSPDNIQELYLGSLEVLGIDPLVHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGIERLAMYIQEVDSVYDLTWNIAPDGSKVTYGDIFHQNEVEQSTYNFEHADVDFLFSFFEQCEKECQQLLELEKPLPLPAYERILKAAHAFNLLDARKAISVTERQRYILRIRNLTKSVAEAYYASREALGFPMCKKEQA
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_TRIL1
Sequence: MNFFTMCMLAAGFGMAIGAFGTGIGQGLAVKSAVEGVSRNPGASGKILTTMMIGLAMIESLAIYVLVVCLIILFANPYKDVAIKALETVAK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL19_AZOSB
Sequence: MNLIQLLEQEEIARLTAGKTIPAFAPGDTVVVQVKVKEGNRERLQAYEGVVIAKRNRGLNSSFIVRKISSGEGVERTFQTYSPLVATIEVKRRGDVRRAKLYYLRQRSGKSARIKEKLDYKSAAGKKA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: CYSP1_ORYSJ
Sequence: MAGGGGKSVAAALAMACFLLILAAFAPPAAAAPPDIMSIIRYNAEHGVRGLERTEAEARAAYDLWLARHRRGGGGGSRNGFIGEHERRFRVFWDNLKFVDAHNARADERGGFRLGMNRFADLTNGEFRATYLGTTPAGRGRRVGEAYRHDGVEALPDSVDWRDKGAVVAPVKNQGQCGSCWAFSAVAAVEGINKIVTGELVSLSEQELVECARNGQNSGCNGGIMDDAFAFIARNGGLDTEEDYPYTAMDGKCNLAKRSRKVVSIDGFEDVPENDELSLQKAVAHQPVSVAIDAGGREFQLYDSGVFTGRCGTNLDHGVVAVGYGTDAATGAAYWTVRNSWGPDWGENGYIRMERNVTARTGKCGIAMMASYPIKKGPNPKPSPPSPAPSPPQQCDRYSKCPAGTTCCCNYGIRNHCIVWGCCPVEGATCCKDHSTCCPKEYPVCNAKARTCSKSKNSPYNIRTPAAMARSVPEQPDSISFVVLNREDLV
What is the function of this protein?
Cysteine protease that may play a role in pollen development (PubMed:15356393).  May be regulated by the transcription factor UDT1 in developing anthers and play a role in tapetum development (PubMed:16141453).  Positively regulated by the transcription factor TDR in developing anthers and may play a role in tapetum programmed cell death (PCD) (PubMed:17138695).
What are the official names of this protein?
Cysteine protease 1, OsCP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: RS3_CHLAD
Sequence: MGRKVHPIGFRLGYIKDWQSKWFAEGETYTKQLHEDIELRKLISKELQSAGVSRIEIERSANKIEISVYTAKPGIVIGKRGTNVDTLKSALEKKTGKKIKLNIKEISQPELDAQLVAESIGEQITKRVSYKRAMKQAVQRAMRLGAQGVKIRCSGRLAGAEMARVHEEAEGRVPRHTLRADIDYAQVHAHTTYGRIGVKVWIYKGDVFPNQSAKASVEQPATAPASERRERAPRRNSNASA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: SERC_VESOH
Sequence: MSQVYNFSAGPAMLPIQVLRQMQDELLEYEDVKASIMEISHRSTDFIAMAQKSEQDLRDLMNIPNHYKVLFLQGGASAQFSMVPINLLHGKTKANYAYTGHWSKKAIVEGSRYCDVNICTNSSDNKYTDIDVFENWDIDPDGAYLHYTPNETIAGLEFDYVPEVDMPLVADMSSSILSREVDVSKYGVIYAGAQKNIGIAGLTVVIVREDLMGSVVANQPILFDYTIQAKNDSMYNTPSTYSWYVASRVFEWLKQQGGLSVIAKINQTKAKTLYDVIDGSNFYSNPVALKYRSWMNVPFLLADENLNGLFVEKAAINNLITLKGHRSVGGMRASIYNAMPQKGINELINFMKVFEKENS
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y768_PASMU
Sequence: MDELILPILILLFLVFVAYFFTKKSKKEENELQMMKKNQEVRKIVENARIRNDLPCLSGFKFGLSLRHIEDMGVSYTHLSRNFGTDLYVIEGRFAPIKNDLIESYFVDINSELGLTRITGNFFSTNNLDFIMEYYKRLLLEKYHEGIVNINDEMNLVLTLDEVIIQLSNIESNISLIYSLIKSDTPEQLAEMLKVQEKDKLGI
What are the official names of this protein?
Uncharacterized protein PM0768.
Protein: MAVS_RAT
Sequence: MTFAEEKTYKYIRYNHSKFCCVDVLEILPYLSCLTTSDQDRLRASYKQLGNQGTLWELFNTLQRRPGWVEVFIRALRICELPGLAEQVTRVYQSYLPPGASLHSLDPLQSPRIPTTVSEPSAFAAGHTIPDSGFQDKPGYPKPVQDTQPPKSPVENSEEPPQANFGAIPRMSGDSLISSPNPPALSPQPSREHPEQEPELGGPSTANVDSVPIATYGPVSPTVSFQPLPRIAPRTNLSPGVTVSALSAKTTLSSSSTGSAFAKGAGDQAKAATCVSTKEGVPTNSVTTSSVPSIKPVPVNTMSSKLPISTKSTAATPSTVPTNIAPSKLPINSVYTGIVPSKVTASVAKASASTMPPERNNKQAKETLEAPATVVTTGSSLTRPDISSRSLHSGPELSKPGVLVSQVDNEPFSACSMDLAISPSTSLGSEPNHGPEENEYSSFRIQVDKSPSVDLLGSPEPLATQQSPEEEEPCASSVSWAKWLGATSALLAAFLAVMLYRSRHLAQ
What is the function of this protein?
Adapter required for innate immune defense against viruses.  Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5).  Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state.  Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response.  May activate the same pathways following detection of extracellular dsRNA by TLR3.  May protect cells from apoptosis.  Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria.
What are the official names of this protein?
Mitochondrial antiviral-signaling protein, MAVS, Interferon beta promoter stimulator protein 1, IPS-1, Virus-induced-signaling adapter, VISA.
What are the subcellular locations of this protein?
Mitochondrion outer membrane. Mitochondrion. Peroxisome.