PharMolix/UniProtQA huggingface dataset:
Protein: EUPD_PHOSX
Sequence: MSIAGLVTTLPWLMNMLRAVPGATGRFERFAGWCYEQLLLKRESLAVERATNHNHEPRDVMTWLINSMDEGDRCAPPTESALQEDARTLISAGSDTVAITFTNILYFLVKHPTIYQKLQRLMDHEFPQGYSSWTYNKAKGVPYIDYIIHETLRLRPAVPMGFLRQTPPQGLQIDEIFIPGDVIVNVPTYTIHRDSRYFYDAAKFIPERWEELSPDTAAYLAFQRGPFTCSGKNLATMQLRMLISCLALRYRIHFAPGEDGVAFATQEKETLTMWIPPLQMVFRPR
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of eupenifeldin, a bistropolone meroterpenoid that acts as an antitumor agent (PubMed:30980906).  The first step of eupenifeldin biosynthesis is the biosynthesis of 3-methylorcinaldehyde performed by the non-reducing polyketide synthase eupA (PubMed:30980906).  Oxidative dearomatization of 3-methylorcinaldehyde likely catalyzed by the FAD-dependent monooxygenase eupB is followed by oxidative ring expansion by the 2-oxoglutarate-dependent dioxygenase eupC to provide the first tropolone metabolite, tropolone stipitaldehyde (Probable).  In parallel, generation of sesquiterpene alpha-humulene from farnesylpyrophosphate (FPP) is catalyzed by the terpene cyclase eupE (PubMed:30980906).  The cytochrome P450 monooxygenase eupD then hydroxylates humulene to humulenol (PubMed:30980906).  The putative Diels-Alderase eupF probably catalyzes the formation of the tropolone-humulene skeleton by linking humulenol and the polyketide moiety (Probable).  The short-chain dehydrogenase/reductase eupG and the flavin-dependent monooxygenase eupH are also essential for eupenifeldin biosynthesis and are likely the additional decorating enzymes of the tropolone-humulene skeleton to produce final eupenifeldin or derivatives (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase eupD, Eupenifeldin biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: RRF_RHOPB
Sequence: MPTGGFDINELKRRMQGATQSLKHELGGLRTGRAAASMLEPVQVEAYGSHMPLNQLATVSVPEPRLLSVQVWDRSMVKAVEKAIVDSNLGLSPATEGQVLRLRIPELNEERRKELVKVAHKYAEATRVAVRHVRRDGLDTLKKLEKNSEISEDDQERLAHEVQKATDATILEVDQLLAAKEKEILTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_LIGS1
Sequence: MKLLEERIKKDGVVLPGNVLKVNQFLNHQIDPELMYKMGEEFARLFKDEEITKIITVESSGIAPAVMTGLVMKLPVVFARKHKSLTLVDNLYTSDVYSYTKKVTNTISVDKKFLTSDDKVLVIDDFLANGQAVQGIFNICDAAGAEIKGVGIVIEKSFQEGAKIIHDRGVRLESLAVISSFDDNQVHFEGEE
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAR3_PANRE
Sequence: KSAYMRF
What is the function of this protein?
Myoactive; induces a rapid concentration-dependent muscle tension increase.
What are the official names of this protein?
FMRFamide-like neuropeptide PF3, KSAYMRF-amide.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: TYSY_BARHE
Sequence: MKTYLDLLSHVLNKGIDRTDRTGVGTRSVFGYQMRFDLQAGFPLLTTKKLHLRSIIYELLWFLRGDTNIAWLKEHGVSIWDEWADEKGNLGPIYGYQWRSWPAPDGRHIDQISNLLMMIKKTPDSRRLIVSAWNPASIKEMALPPCHCFFQFYVADGKLSCQLYQRSADIFLGIPFNIASYALLTMMIAQVSGLKVGDFIHTLGDAHLYSNHFEQAQHQLSRIPNALPFMRINPAVTDLFSFKFEDFELLNYDAQPHIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAPD_ECO57
Sequence: MHTNWQVCSLVVQAKSERISDISTQLNAFPGCEVAVSDAPSGQLIVVVEAEDSETLIQTIESVRNVEGVLAVSLVYHQQEEQGEETP
What is the function of this protein?
Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase.  It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
What are the official names of this protein?
Chaperone NapD, NapA signal peptide-binding chaperone NapD.
What is the protein family that this protein belongs to?
Belongs to the NapD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPB3_ASFWA
Sequence: MEKIFQNVEIKPFLIDFSNPFIKNAAKRLFQLEEQLPLVPVNVVMDFKGINRAAVHGLSRVLQDEIPNYMLDIKPGGYKIEDSTDLFMTEQFIRNRINFIPIYAKNETLVFALRSLNNSCEVKTIYSRDLIQVAGPKLKYPIFNPTFEIGFLQPGKSLIIEDIYIKKGIGRKHAAFNLAVKTHFSHLDIEQYPTDKKEYMALSGYKQSSMTSDPRHHRLGLCFPAVPLPHINQAVRTYLKNACRVIIGRIQSIQKIYENFEEPQPELVLFSMDEEKTKAIITIKDETHTIGNLLKTYIYEMIPDISFVGYQCVPHKQEMVLTIIHKASQEDLITLLEKSIQNIIQTFQILEKNVDELIA
What is the function of this protein?
Component of the DNA-directed RNA polymerase (RNAP) that catalyzes the transcription in the cytoplasm of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase RPB3-11 homolog, RPB3-11 homolog.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion. Note=Found in association with viral nucleoid.
Protein: RIMO_STUS1
Sequence: MSKTPTVGFVSLGCPKATVDSERILTQLRMEGYQIVPSYEDADVVVVNTCGFIDSAKAESLDAIGEAIAENGKVIVTGCMGVDENNIRGVHPSVLAVTGPQQYEQVVNAVHEVVPPSIEHDPFVDLVPPQGIKLTPRHYAYLKISEGCNHSCSFCIIPSMRGKLVSRPVGDVLSEAERLVKAGVKEVLVISQDTSAYGVDLKYKLDFWNGQPVKTRMLELCEELGKMGVWVRLHYVYPYPNVDDVIPLMAAGKILPYLDIPFQHASPKVLKAMKRPAFEDKTLARIKKWREICPELTIRSTFIVGFPGETEEDFQYLLDWLTEAQLDRVGCFQYSPVDGAPAEAMNLEPVPDEIKQDRWDRFMAHQQAISAARLQLKVGKELDVLIDEVDEDGAIGRSWADAPEIDGMVYVDSEQPLQPGDKVRVRVTNADEYDLWAEVI
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
Protein: RDGC_BURCJ
Sequence: MWFKNLQLHRLPAPWAVTADRMEKWLAPHAFQPGSSVEMQRVGWASPRDDGALVYSINRQMLLVFRAEKKLLPASVVNQVTKARALELEEQQGFKVGRKQLRELKEQVTDELLPRAFSIRRDTRVWIDTANGWLVIDAAAQALADDVRSLLVKSIDGLPLAGVQVARSPVAAMTDWLLSGDAPGGFTVDQDAELRSSGEGGATVRYVGHALEANDMRRHIEAGKQCMRLAMTWDDRISFVLTPSLTIKRVTPLDVIKEAADPTAQNDDERFDSDFTLMTGELARMLTSLVDILGGDRQDSVPQPAAA
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: GATC_RENSM
Sequence: MAEINRDDVAHLAQLAHIDMSESELDRMAGELAVIVDSVKSVSEIAGDDAPATSHPIPLSNVLREDTVGHVLSQEQVLSGAPDAEDGRFKVPAILEED
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: PSBL_CERJA
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: TGT_GLAP5
Sequence: MKYELKKTNGNARRGRLTFSRPKGEYHVETPAFMPVGTYGTVKGMTPEEVAQTGAQILLGNTFHLWLRPGQEIMRQHGDLHDFMQWHGPILTDSGGFQVFSLGKLRKIKEEGVYFQNPISGEKVFLSPEKSMEIQYDLGSDIVMIFDECTPYPATFDYAKQSMEMSLRWAKRSRDRFDELQNPNALFGIIQGGVYEELRKVSVEKLVEIGFDGYAVGGLAVGEPKEDMHRILEYVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTNGIVKIRNAKYRNDISPLDPECDCYTCKNYTKAYLYHLDKCGEILGARLNTIHNLRYYQRLMAEIRQAIDEDRFDDFVVEFYQRIGKEVPPLQLAKEGENA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RECA_SALG2
Sequence: MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPVYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGDNVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYNGEKIGQGKANATTWLKENPATAKEIEKRVRELLLSNQNATPDFAVDDSEGVAETNEDF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STIL_MOUSE
Sequence: MNTRFPSSKMVPFHFPPSKLALWNPMPIGECIYLHLSYYRKPKLMVTEKAIRLAYRHAKQNKKNVPCFLLGSLTVDEDEEGVTLTIDRFDPGREIPECLERTPTASLPGDFLIPCRVHIQGLGSRDVIVHNADDFSSALKALQYHVCSKDFLDCGKLLCLRAQITPRESLDGVDFNLQWTAVTLANSFKCVPVKPIPIIPTALARNLSSNLNISQVQGTYKHGYITMDETRKLLLLLQSDPKVSSLPLVGIWLAGIIHVYSPQVWACCLRYMFSSSIQERVFSESGNFIIVLYSLTHKEPEFYECLPCESRTPDLQFQLLTNKETLHLFNNVEPSGKNPIHFELSAESQDAEAEAEVLSKISKTLPVKRSSQKVSPGKIPINKHDTDLEDEDFSPRPIPSPHPVSQKISKVQPSVPELSLVLDNNFTESSNQSNPLEMMTVENPLLIKPSQPELCDAKHSSEATTGEPFRRGPTNQLSQDTALRQSRGKQSSTCKKESLQFRNTNAKPSLSVPSPDVAEKLQAVSAGSMQKEDYPVRPSTLDSRQPSLAPQAQPHNLVFSTHNSTRPMELQVPTPSLPSYYPTNVCSCCQHHGHIQYSTINSWQGNTVGSIQDLRSESLPKHAFFHSSGCPSLCPNAIYSSSSPVSMKQGGMGAYSPHSNGEPSPVAGPSHVDSCVPHPCAMCMHTPNTAPDNGMMGLSPDAYRFVTEQDRQLRLLQAQIQRLLEAQSLDPGSHKTVATMEDTVKAARQMELVSMEAQSSPGLHMRKSVSIAVSTGASLFWNAAGDDQEPDSQPKQDDTKISSEDMNFSVDINNEATSLPGSASSLKAVDIPSFEESNLAVEEVNQPLPESNSSSEQSKEPGVPVFFPNALLAESVSMCLQTAPTEGASNSTELPQGTKDEPYRPSDNQKIYQDLLGQVNHLLSNASQETEEPPTKAVVTNHECAKTQNTHHARKKRHNSGLVDKDCVLSATIKQLRSLGVKIDSPTKVKKNEQKVDHASVLACISPEAVISGLNYMSFGNVGMSSLSPTGVDLSMEANAIALKYLSENQLSQLSLARSKQNNGDSSVGLLHINSDRSTVGLSLVSPSNMSFATKKYMKRYGLLQSSDNSEDEEEPPSHADSESDHVLNRNPACRPVQCGHEKEPSWNACEIAQCSDCGSADTRTDVPVLRNITNQAVQPRATEHLNEDSAISLRNLKPNPAMNLRTGKAEFTHHPEKENERDIAVFPGTLPSPETLKQMNSMDSVGTFLDVKRLRQLPKLF
What is the function of this protein?
Immediate-early gene.  Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1.  Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1.  Plays an important role in the regulation of centriole duplication.  Required for the onset of procentriole formation and proper mitotic progression.  During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (By similarity).
What are the official names of this protein?
SCL-interrupting locus protein homolog.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: IHFA_BURPS
Sequence: MARDVPASTPAGDTPTLTKAELAELLFDSVGLNKREAKDMVEAFFEVIRDALENGESVKLSGFGNFQLRDKPQRPGRNPKTGEAIPIAARRVVTFHASQKLKALVENGAEPDLAR
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PDXS_DEHMC
Sequence: METGTFKVKSGLAQMLKGGVIMDVTTPEQAKIAEEAGACAVMALERVPSDIRAAGGVARMADPTIIEQIMKVVSIPVMAKCRIGHFVEAQILESMGVDYIDESEVLTPADENFHVWKHDFKVPFVCGCRDLGEALRRIGEGAAMIRTKGEAGTGNIVEAVRHMRSVMGSVRRVQSMSPDELSAYAKEINAPLELVLELHKTGKLPVVNFAAGGVATPADAALMMQLGADGVFVGSGIFKSSNPSAMAKAVVKAVTHYKDAQILAEISKGLGDAMPGLDIKQIDPDKLISQRGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: Y3035_MYCTU
Sequence: MGGCGSADSWVEAAPAQGWPAQYGDAANSSYTTTNGATNLTLRWTRSVKGSLAAGPALSARGYLALNGQTPAGCSLMEWQNDNNGRQRWCVRLVQGGGFAGPLFDGFDNLYVGQPGAIISFPPTQWTRWRQPVIGMPSTPRFLGHGRLLVSTHLGQLLVFDTRRGMVVGSPVDLVDGIDPTDATRGLADCAPARPGCPVAAAPAFSSVNGTVVVSVWQPGEPAAKLVGLKYHAEQLVREWTSDAVSAGVLASPVLSADGSTVYVNGRDHRLWALNAADGKAKWSAPLGFLAQTPPALTPHGLIVSGGGPDTALAAFRDAGDHAEGAWRRDDVTALSTASLAGTGVGYTVISGPNHDGTPGLSLLVFDPANGHTVNSYPLPGATGYPVGVSVGNDRRVVTATSDGQVYSFAP
What are the official names of this protein?
Protein Rv3035.
Protein: SYC_BRUSU
Sequence: MPDTAPQLRLYNTLTRTKEAFAPIDAKNVRMYVCGPTVYDFAHIGNARPVIVFDVLFRLLRHVYGAQHVTYARNITDVDDKINARAARDYPDLPFNEAIRKVTESTNAQFQADVTALGNLQPTVQPRATEHMDEMRAMIDRLVQRGVAYVAQDHVLFSPSAMNARKGPRYGALARRSLDEMLAGARVDVASYKRDEMDFVLWKPSKKGEPGWPSPAGIETLGRPGWHIECSAMSMAKLLEPFGGGLKCDDPERNQFDIHGGGIDLVFPHHENEIAQSCCALGTERMANIWMHNGFLQVEGQKMSKSLGNFITIRDVLNDGLPQLGEWGDNTVRDRWAGLAARLSMLQTHYREPINWTAQRLAESADELHRWYGLLRDEGFGAPEKLSHASAVAAALCDDLNSWAAITALRQAFKVRDVAALGEGMALMGLLDPYFVTASDVPIFARADVDASAIAARIAERLNFINAKNWAEADRIRDELLQEGVQLKDSKDPATGERITTWDVVG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPC4_CLAPU
Sequence: YLFLFRFIGVDTLRRSKPPIRLNTLIPVAKVFGANFSFASLRLEILIFSGLTGWNSKSKASHVYSSSVGYSSNSIASLSIIVSNTSSRNGSWISTNRTPICLSPIV
What are the official names of this protein?
Uncharacterized 11.6 kDa protein, ORF4.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ACES_CULTO
Sequence: SGKKVDAWMGIPYAQPPLGPLRFRHPRPAERWTGVLNATKPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYINVVVPRPRPKNAAVMLWIFGGGFYSGTATLDVYDHRTLASEENVIVVSLQYRVASLG
What is the function of this protein?
Rapidly hydrolyzes choline released into the synapse.
What are the official names of this protein?
Acetylcholinesterase, AChE.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Synapse. Secreted. Cell membrane; Peripheral membrane protein.
Protein: PRS7_SCHPO
Sequence: MPPKEDWEKYQKPVDTEEENDKNPPPLDEGDIELLKSYATGPYARELAAIKEDTEAVLKRINDTVGIKESDTGLAPISFWDVAADRQRMSEEQPLQVARCTKIIENEQSAEKNAYVINLKQIAKFVVSLGERVSPTDIEEGMRVGCDRNKYAIQLPLPPKIDPSVTMMQVEEKPDVTYGDVGGCKEQIERLREVVELPLLSPERFVKLGIDPPKGIMLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAIGGARFDDGAGGDNEVQRTMLELITQLDGFDPRGNIKVLFATNRPNTLDEALMRPGRIDRKVEFGLPDLEGRAHILRIHAKSMAIDKDIRWELIARLCPSQTGAELRSVCTEAGMFAIRARRRVATEKDFLDAVQKVVKGNQKFSSTADYMNMSS
What is the function of this protein?
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins.  The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
What are the official names of this protein?
26S proteasome regulatory subunit 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CDN2D_MOUSE
Sequence: MLLEEVCVGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALELLKQGASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLAPESDLHHRDASGLTPLELARQRGAQNLMDILQGHMMIPM
What is the function of this protein?
Interacts strongly with CDK4 and CDK6 and inhibits them.
What are the official names of this protein?
Cyclin-dependent kinase 4 inhibitor D, p19-INK4d.
What is the protein family that this protein belongs to?
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MNME_BACVZ
Sequence: MDTIAAISTPMGEGAIAIVRLSGPEAVKIADKMYKGPKGKTLSSAESHTIHYGHIADSTTGRIIEEVMVSVLRAPRTFTREDVIEINCHGGIVTVNQVLQLALREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALVRRLRDELLETLAHVEVNIDYPEYDDVEEMTHQLLVEKASGVKKEIEALLRTSEQGKILREGLSTVIIGRPNVGKSSLLNSLVHETKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDTAGIRETEDIVERIGVERSRQVLKEADLILLVLNHSEELSEEDVKLFEAVEGMDVIVIMNKTDLEAKIDAERVKELAKGRPVVTTSLLKEEGIQDLEEAIQSLFYTGAIESGDLTYVSNTRHISILHQAKQAIDDALNGIEQDVPIDMVQIDLTRCWELLGEIIGDAVHESLIDQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MID49_XENLA
Sequence: MAELQIRKKEKKSGDGIGTMVDFLLANARLVLGVGGAAMLGIATLAVKRLIDRATSPPSDKEAEEKAEQKSIEESWKEAVLKKASPTLRRKEDLEHHCAPLSLPDPSQKMPEATGTSQVKASDEIKKIPICFTLQERLLNYHTHHASVPEVQMEEARQLVLDIKKELQEFLHAKHPEMPFLALHLGGSFGNRLPMSCLDHACLIMPLVLEPDLWCVIPGQKTILSDPNFCMVKRIDLEYTSRGSSPWDRFLVGAYLSSRTMVQSLHKTIVGSINWPAIGTVLDCTIKPDITSDELKLEVVHPNGHMIIRILPMAVIKDADLLAHCCATAPAENLWQRSFYKKEVSRLQELDSSDSGIRLKCLQILKGICRDCPSLCHLNSTHLRHILLHLSTESSDWTETALADRFLQVLEELIGYLDKGFLPSYFNDKLNLFSSLKAEDIEELGYGLYQVFSEPDDVLKRER
What is the function of this protein?
Mitochondrial outer membrane protein which regulates mitochondrial organization (By similarity).  It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins (By similarity).  Regulates DNM1L GTPase activity (By similarity).
What are the official names of this protein?
Mitochondrial dynamics protein MID49, Mitochondrial dynamics protein of 49 kDa homolog, Mitochondrial elongation factor 2, Smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the MID49/MID51 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: NDK_PELPD
Sequence: MERTFAIIKPDAVERRLAGTVIDRIEANGFTIVGMKKIKLSKEQAGGFYCVHRERPFFGELCDFMSRSPVIVLCLEKENAIADWRKLMGATNPANAEPGTIRRDFALSLSENSAHGSDAPETAAFEIAYFFNALELV
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBE_XYLFA
Sequence: MSDSPRRFPTPLLLTGVMGVLILIALLTFTLMRSWDNAPDQSALLGKPAPNFSLPLLHDPSLQISNTDLAGAPYLLHVWGSWCAACATEQPVLTHFALSKRVRVIGYNWKDRREDALQWLEQLGNPYLAVVSDPEGKTAMDWGVTAAPTTFLIDGRGIVRWHHKGALNQQIIEHKLLPILADIEHSPTAAPALHQAP
What is the function of this protein?
Involved in disulfide bond formation.  Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme.  Possible subunit of a heme lyase (By similarity).
What are the official names of this protein?
Thiol:disulfide interchange protein DsbE, Cytochrome c biogenesis protein CcmG.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.