PharMolix/UniProtQA huggingface dataset:
Protein: RLMH_CELJU
Sequence: MRIRIIAVGTKMPEWVEQGYAEYAKRMPRDLAVEMVELPLAQRSKNSDVAKAMEKEGEAMLAAIGKGEQVIALDVKGKPWSTEQLAEQLASWKMSGSNFCLLIGGPDGLAPAALAQATIKWSLSPLTLPHPLVRILLIEQLYRACTILQNHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYD_LEUMM
Sequence: MKRTNYAGLIDETYLNQTVTLTGWVQKRRDFGDLIFVDLRDREGIVQLTFNATNADALAVAEKVRSEYVLKITGHVIERAENQINTKIKSGTIEVDVTEAEILSTSKTPPFYIEDDVNANEELKLQYRYLDLRRPEMQKNLRIRSKIMSSAMHFMDTHDFINIETPVLAKSTPEGARDYLVPSRVFPGSFYALPQSPQLFKQLLMGAGFDRYFQIARAFRDEDLRGDRQPEFTQMDVETSFMTADEIRELVNAWVKAMMHDVVDFDLDTAEIPTLTWQESMDRFGTDKPDLRIAYEIKDLSETVKNSEFGVFANAIKGGGVVKALAVPGGADHYSRKDIDKLTKYIERFGAKGLAWMKVAPEGLTGPIAKFFDDEAQAALIASADAQVGDLLLFGAGRADVVSATLDYLRRETAKALDLIDQTNPWAFAWIVDWPLFEYSEDFDRWIAAHHPFTMPNEEDLHYLNDGEDPHKAHAQSYDLVLNGYELGSGSIRIHRMDIQEKMLKALGFTPEKAHEAFGFLLEGMEYGFPPMGGIALGLDRLAMLLAGQENIREVIAFPKNSRATEPMTEAPTRVEGKQLNELGLFVPEAE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_I02A1
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPENHEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNDLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRIRDNMTKKMVTQRTIGKKKQRLNKKSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPDWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAM
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: MLTF_YERPG
Sequence: MTRIKLSYFTIGLVALLLALALWPNIPWRNGQEGQLDQIKARGELRVSTISSPLIYSTEKDTPSGFDYELAKRFADYLGVKLVIIPHHNIDDLFDALDNDDTDLLAAGLIYNRERLNRARTGPAYYSVSQQLVYRLGSPRPKSFSDLKGQVVVASGSAHMTTLKRLKQTKYPELNWSSSVDKSGKELLEQVAEGKLDYTLGDSATIALLQRIHPQLAVAFDVTDEEPVTWYFKQSDDDSLYAAMLDFYSEMVEDGSLARLEEKYLGHVGSFDYVDTKTFLSAIDNVLPSYQHLFEKHAGDIDWKLLAVIAYQESHWNPQATSPTGVRGLMMLTRATADGLGVKDRVDPEESIRGGAIYLQRLMKKLPETIPEDERIWFALAAYNLGYGHMLDARRLTKNQNGNPDSWVDVKMRLPMLSQKRYYPSTTYGYARGHEAYNYVENIRRYQVSLVGYLQEKEKKAAQHAAIEAELGKSNPVVGPGWSIGD
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: BIOB_CORU7
Sequence: MNDISSQTPGILATAREQVLQRGEGLSQEQVLEVLNLPDEQIEELLALAHEVRVKWCGEEVEIEGIVSLKTGGCPEDCHFCSQSGLFETPVRSVWLDIPLLVEQAKQTAKTGATEFCIVAAVKGPDENLMRQLEVAVEAIRAEVDINVAASVGILTQEQVDRLTAIGVHRYNHNLETSRSNFPNVVTTHSWEERYETLKMVKESGMEVCCGGILGMGETREQRAEFAAELASLEPHEVPMNFLDPRPGTPFADYPVMAGSEALKTIGAFRLALPRTTLRFAGGRELTLEDFGTEAGLLGGINGMIVGNYLTTLGRDQEADVDMLNRLSLPIKALNRSV
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: MIAA_BURMA
Sequence: MSERNAASARTVACLLGPTASGKTAAALALAARRPIEIVSVDSALVYRGMDIGTAKPTRDERAAVPHHLIDIVDPADAYSAAEFRADALRLVAQIAARGRTPLLAGGTMLYYRALTQGLNDLPAADPDVRATLDADAARDGWPALHARLAGIDPATAARLAPNDSQRIQRALEVYLLTGQPMSALLAAPPRDNDAAAGLRFVPVALEPSERAVLHARIAARFDAMLEAGFIDEVERLRRRDDLHLGLPSMRCVGYRQAWEYLDGCTDYRTMRDKGIFATRQLCKRQLTWLRAMPERIVVDCCAPDATVRAVDALERVLDGRAPA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: TOX1_OXYTA
Sequence: MKIVLVFVCTLYLAQATYLSEQDVNEVSEFLEALDQANEAASEMVEAAETEEARDWECLPLHSSCDNDCVCCKNHHCHCPYSNVSKLEKWLPEWAKIPDALKRCSCQRNDKDGKINTCDKYKN
What is the function of this protein?
Weak blocker of vertebrate P/Q-, N- and L-type voltage-gated calcium channels (Cav1 and Cav2) (By similarity).  Is both paralytic and lethal when injected into lepidopteran larvae.  Is not toxic to mice.
What are the official names of this protein?
Omega-oxotoxin-Ot1a, Omega-OXTX-Ot1a, Oxytoxin-1, OxyTx1, Tx-1.
What is the protein family that this protein belongs to?
Belongs to the spiderine family. Spiderine subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RBL_BIXOR
Sequence: FVGFKAGVKEYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTAVWTDGLTSLDRYKGRCYHIEPVAGEENQYICYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEVWKEIKFEFEAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MOKH_MONPI
Sequence: MALSPVQDPPSHTDKTMPRRAFRRSCDRCHAQKIKCIGSEGAVARASCQRCQQAGLRCVYSERCPKRKLPKPNPAESSPASSTAGLHTSSSDSSPPVPSDGLPLDLPGPDSSGVSLQFLDPSADCDWPWSSIGVDETVVNNCLDLSHGHGHGDLSCQLELPMPDLPSPFEFSAEKSPSPSVSGSIAGAVSAQRELFDGLSTVSQELEAILLAVAVEWPKQEIWTYPIGTFFNASRRLLVYLQQQSNTRSDQGMLNECLRTKNLFMAVHCYMLIVKIFTSLSELLLSQIRHSQAGQLTPLEGHQFEPPPSSSRDRSSVDTMPIFNPNLHIGGLFSYLNPFMHALSSACTTLRVGVQLLRENESALGIPPAQGVAASVSMGKEEWADGEDVASAVTTADEDLRQPASRILSMVWSDEVGDQKAKSADAAGPRSRTLAVLRRCNREIFSLARQHNLAS
What is the function of this protein?
Transcription factor that regulates the gene cluster that mediates the biosynthesis of monakolin K, also known as lovastatin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:18578535, PubMed:19693441, PubMed:19968298).  Monakolin K biosynthesis is performed in two stages (PubMed:19693441).  The first stage is catalyzed by the nonaketide synthase mokA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:18578535, PubMed:19693441).  This PKS stage is completed by the action of dehydrogenase mokE, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydromonacolin L (PubMed:19693441).  Covalently bound dihydromonacolin L is released from mokA by the mokD esterase (By similarity).  Conversion of dihydromonacolin L into monacolin L and then monacolin J is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mokC (PubMed:19693441).  Finally, mokF performs the conversion of monacoline J to monacoline K through the addition of the side-chain diketide moiety (2R)-2-methylbutanoate produced by the diketide synthase mokB (PubMed:19693441).  HMG-CoA reductase mokG may act as a down-regulator of monacolin K production (PubMed:18578535).
What are the official names of this protein?
Transcription factor mokH, Monacolin K biosynthesis protein H.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS3_TRIV2
Sequence: MGQKIHPVGFRLGITQEHQSRWFAEPSRYPELLQEDHKLRQYIEQKLGRLAQNNAGISEVRIERKADQIDLEVRTARPGVVVGRGGQGIEALRTGLQTLLGGNRQIRINVVEVQRVDADAYLIAEFIAQQLERRVSFRRVVRQAIQRAQKAGIQGIKVQVSGRLNGAEIARTEWTREGRVPLHTLRADIDYSYCTAKTVYGILGIKVWVFKGEIIPGQEVAAPPPSTRDRDRDRGDRDREPRRRQQQRRRQQFEDRSNEG
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PADI1_HUMAN
Sequence: MAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSGSSGVEVFMVYNRTRVKEPIGKARWPLDTDADMVVSVGTASKELKDFKVRVSYFGEQEDQALGRSVLYLTGVDISLEVDTGRTGKVKRSQGDKKTWRWGPEGYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDMSPMLLSCNGPDKLFDSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVERQPGEQEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPWIMTPNTQPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVENRNDRWIQDEMEFGYIEAPHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYVTREIPLPGPSSLDSFGNLDVSPPVTVGGTEYPLGRILIGSSFPKSGGRQMARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFVPTSDQKGFRLLLASPSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDNLHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGKYLGIPKPYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNVRRKPFPFKWWNMVP
What is the function of this protein?
Catalyzes the deimination of arginine residues of proteins.
What are the official names of this protein?
Protein-arginine deiminase type-1, Peptidylarginine deiminase I, Protein-arginine deiminase type I.
What is the protein family that this protein belongs to?
Belongs to the protein arginine deiminase family.
Protein: VE1_CRPVK
Sequence: MAEGTDPLDDCGGFLDTEADCLDCDNLEEDLTELFDADTVSSLLDDTDQVQGNSLEPFQHHEATETLKSIEHLKRKYVDSPDKSLGIDNSVNALSPRLQAFSLSGQKKAVKKRLFGTDGDEAASGAESLQVESGFGSQQSVSDTPVTDILNANTARVKHLLLFRQAHSVSFSELTRTFQSDKTMSWDWVGGLADIHVSVLESLQTSLRSHCVYVQYDLNFAETNASSLLLLLRFKAQKCRDGVKALLSQLLGVQDLKVLLEPPKTRSVAVALFWYKRAMVSGVFSYGPMPEWITQQTNVNHQMLQEKPFQLSVMVQWAYDNHLQDESSIAYKYAMLAETDENARAFLASNSQAKYVRDCCNMVRLYLRAEMRQMTMSAWINYRLDGMNDDGDWKVVVHFLRHQRVEFIPFMVKLKAFLRGTPKKNCMVFYGPPNSGKSYFCMSLIRLLAGRVLSFANSRSHFWLQPLADAKLALVDDATSACWDFIDTYLRNALDGNPISVDLKHKAPIEIKCPPLLITTNVDVKSDDRWRYLFSRICVFNFLQELPIRNGTPVYELNDANWKSFFKRFWSTLELSDPEDEGDDGGSQPALRLHTGGTSQSL
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: METAS_SALDC
Sequence: MPIRVLDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDARESRNTPAEHLNNFYCNFDDICDQNFDGLIVTGAPLGLVEFNDVAYWPQIRQVLEWAKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAHTLAGEYFRDVEAGLNPEVPYNYFPKNDPQNIPRATWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_SALPK
Sequence: MAILGLGTDIVEIARIEAVISRSGERLARRVLSDNEWAIWETHQQPVRFLAKRFAVKEAAAKAFGTGIRNGLAFNQFEVFNDELGKPRLRLWGEALTLAEKLGVAHMHVTLADERHYACATVILES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_STRP2
Sequence: MLKMTLNNLQLFAHKKGGGSTSNGRDSQAKRLGAKAADGQTVTGGSILYRQRGTHIYPGVNVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPIAK
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: IF1_PSEMY
Sequence: MSKEDSFEMEGTVVDTLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVRVELTPYDLSKGRITYRAR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPK_CAEEL
Sequence: MSDDVNSSATSTSSSTVHFDDTPFEDVYEIETELGSGQFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGGELFDHVCAKECLDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRGDSQIKIIDFGLSREIEPGAVVKDMVGTPEFVAPEVVNYEALSPATDMWAVGVVTYILLSGGSPFLGDNRDETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWIRGPEGNAIDIRKASCITISHIQSFKTRQRWKRCVELVMVLLKASKSSRRIGDGRFDEEDMVASCTLICAEEGNLRALHKLSALHKLLPNATRKSLKSSFSEPNGATAMHCAAKYGHAEVFNYFHMKGGNICARDDNGDTPLHVACRFAQHTVAGYVANEKIDVDSINKTGETALHCAVESADTRVVRLLLQLRPRLDLPNASGDTVLHLAADSINPRIVPLLVCLAPPLHLRNIREETPLHVAAARGHVDCVQALLDANSPIDAVEQDGKTALIIALENGNVDIASILITNGCDINHADHHGDTALHIASKHGLLQAVQTLCHCAVTVDSVNANKKTALHLAAHYGHVDIIRVLLLARADVTLRGDDGLTAELVAVAAERLEAHSLLKMVKSQEIREEYISQLYPLDTSLRRIKLKLLGHSQSGKTRLVQTLHSSRGISSFLESVTRRISDHYSPSSSMKDDGIHSTNGSFVSESNNNSSFDLAAAAGSKYAPPHSQYTRGIDVQTVNINGCGEFSVWEFGGYEPMHTCYDHFVGNADCIHLILYRTSDPTEVQYKQILYWMNFLKGRVTPFEPIGHCGFSSRRSKVIIVGTHATSSLFPQMNQEGEYVSSDIEAMLNTVRLRFETHFDMDHRLILLDATNPSCIGMKTLKMELAKCRTNILAKLLKPLAILDTVVNHLNLVRKKHANFPVITWPDFIQLVRNEINPLTGDAHCRQIVQQLQLIGELVYLRNDLCDADYVVLNAEWFGTHILGQLLSAEFLSKASPNGSYHTSSLAKIFPEIPEQSDLMTILEVLQLCAPDARTGAHEFPVFIQTEAPDSIWRPYSLKEKERDTVYGGVRILPMRGMERSLHSTFPRIQVALRRSINDYQPAKDTQLHQWSECSKLVSQDREAVIRMVGDAVEIRARGPSESATSMFYFMEDLINLVEHAAAEVGPGISLERHFISPKHLKEHREHPALFPPESMMEMQQRESLSVKGTQDEEELFTDVVCFGSRDVARHLTLGIDVGVADLQMASRCELACLLDPPHAMGRDWSILAVKLQLTDQVPDVDSTGQSLSRTDQLLNEWAIHHPEQASVGNLCRILVELGRCDARDALYRTVPLYVFAPLEDQFLLETNDSGVVSSCHSSSEHNPINI
What is the function of this protein?
Negative regulator of epidermal barrier repair and innate immune responses to wounding (PubMed:19164535, PubMed:27661253).  The role in epidermal tissue integrity and wound healing is established through the inhibition of epidermal microtubule stability, possibly via the negative regulation of the microtubule minus-end binding protein ptrn-1 (PubMed:27661253).  In epidermis, prevents expression of specific unc-44 isoforms probably by promoting nuclear localization of pinn-1, which in turn may affect sydn-1-ssup-72-mediated regulation of alternative polyadenylation of unc-44 mRNA (PubMed:28087624).  Appears to act downstream of or in parallel to muscarinic signaling in the regulation of autophagy (PubMed:17785524).
What are the official names of this protein?
Death-associated protein kinase dapk-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Note=Exhibits movement along microtubules.
Protein: LDHA_GILMI
Sequence: MSTKEKLISHVSKEEAVGSRNKVTVVGVGMVGMASAISILLKDLCDELALVDVMEDKLKGEVMDLQHGSLFLKTHKIVADKDYSVTANSRVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCILMVVSNPVDILTYVAWKLSGFPRHRVIGSGTNLDSARFRHIMGEKLHLHPSSCHGWIVGEHGDSSVPVWSGVNVAGVSLQTLNPKMGAEGDSENWKAVHKMVVDGAYEVIKLKGYTSWAIGMSVADLVESIVKNLHKVHPVSTLVKGMHGVKDEVFLSVPCVLGNSGLTDVIHMTLKADEEKQLVKSAETLWGVQKELTL
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIUC_PSEAE
Sequence: MLLHIPAIFTAEEVSRIRAALEQAEWADGKATAGYQSAKAKHNLQLPQDHPLAREIGEAMLQRLWNHPLFMSAALPLKVFPPLFNCYTGGGSFDFHIDNAVRDVHGGRERVRTDLSSTLFFSDPEDYDGGELVIQDTYGLQQVKLPAGDLVLYPGTSLHKVNPVTRGARYASFFWTQSLVREDSQRTLLFEMDQSIQRLTRDVPDHPSLIRLTGTYHNLLRRWSEL
What are the official names of this protein?
PKHD-type hydroxylase PiuC, Iron-uptake factor PiuC.
Protein: RS11_ECOL5
Sequence: MAKAPIRARKRVRKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: TNR1B_HUMAN
Sequence: MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS
What is the function of this protein?
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha.  The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2.  This receptor mediates most of the metabolic effects of TNF-alpha.  Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, TNF-R2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted. SUBCELLULAR LOCATION: [Tumor necrosis factor-binding protein 2]: Secreted.
Protein: PFA3_DEBHA
Sequence: MLISHPRIMIRHAPWVTSIETFCCSLATLFPKVFYTSVLTWSVYALIVHGCYDTLMTTQETSIFAIAIGLIGLTLYILCLYTYFKVLRAGPGSPSDFEELRIRNILSLSKPKYNSANPYDTNDNMATSASLLANAEGVDEIESIESEQPPSEYMTLHMLKSNNSSYRYCTKCSVWKPDRCHHCSTCNRCVLRMDHHCPWFAMCVGFYNHKFFAQFLMYLTAYSGFDFVVSLSILWKFFADEKYNDHYLSLNLVFLFVLSLAFFITVGGFSAFSLYLVFRNKTTIEFQENRWNFKNDKNGKSFQYEFDGSGKKKKLGNIFDLGCGRNWRSIMGPSWYYWLLPVTVTNKSIDARLENGINFEIDQDVYDRWCYNAQLQDQLNQQLADYKNRIRMEREANQTTDTNPF
What is the function of this protein?
Palmitoyltransferase specific for VAC8.  Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).
What are the official names of this protein?
Palmitoyltransferase PFA3, Protein fatty acyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.