PharMolix/UniProtQA huggingface dataset:
Protein: PTR25_ARATH
Sequence: MSTSIGDNETGAIVSNENVEFSVDFRGNPSIRSSSGAWKSSGFTMCAEVAEKFAYFGIASNLITYFTEALGESTAVAASNVNLWLGTAAFLPLIWGSIADSFLGRFRTILLTSSFYIMGLGLLTFSATIPSLCNDQETRESCVSQVKVIIFFCALYLIALGEGGFKVCLRAFGADQFDEQDPNESKAKSSYFNWLYFAISIGILTTRLVTNYVQENLSWALGYAIPCLSMMLALFLFLLGIKTYRFSTGGEGRQGKKHDNPFVRIGRVFVAAARNRRQTPSDTCLLLPNESTKKFRFLDRAVISCDSYEVEEAKAVLSLIPIWLCSLVFGIVFAQSPTFFTKQGSTMDRSISSTLQVPAATLQCFISLAILVFIPIYDRLFVPIARSITRKPAGITTLQRISTGIFLSIISMVIAALVEMKRLKTARDHGLVDSPKATVPMSVCWLIPQYILFGVSDVFTMVGLQEFFYGEVPPQLRSMGLALYLSIIGIGNFLSSFMVSVIEEATSQSGQVSWFSNNLNQAHLDYFYWLLACLSSLAFIFTVYFAKSYLYNSPK
What are the official names of this protein?
Protein NRT1/ PTR FAMILY 5.12, AtNPF5.12.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MBCT_MYCTU
Sequence: MSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTTAEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQRTRPGQLQLRQSVDLTPALYQELRAT
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Neutralized by cognate antitoxin MbcA (PubMed:30315706, PubMed:30792174).  Degrades NAD(+) by phosphorolysis.  Expression in the absence of its cognate antitoxin MbcA causes dramatic reduction of intracellular NAD(+) levels and is deleterious to cell growth, causing cell death.  In a SCID mouse infection model, mice infected with bacteria overexpressing this protein survive longer.  Overexpression of this protein in a mouse infection model at 21 days leads to bacterial death, and shows a synergistic 100-fold increase in mouse survival when combined with isoniazid treatment (PubMed:30792174).
What are the official names of this protein?
NAD(+) phosphorylase MbcT, Mycobacterial cidal toxin MbcT, Toxin Res, ucAT8 toxin.
What is the protein family that this protein belongs to?
Belongs to the MbcT/ParT/Res family.
Protein: PRNC_PSEFL
Sequence: MTQKSPANEHDSNHFDVIILGSGMSGTQMGAILAKQQFRVLIIEESSHPRFTIGESSIPETSLMNRIIADRYGIPELDHITSFYSTQRYVASSTGIKRNFGFVFHKPGQEHDPKEFTQCVIPELPWGPESHYYRQDVDAYLLQAAIKYGCKVHQKTTVTEYHADKDGVAVTTAQGERFTGRYMIDCGGPRAPLATKFKLREEPCRFKTHSRSLYTHMLGVKPFDDIFKVKGQRWRWHEGTLHHMFEGGWLWVIPFNNHPRSTNNLVSVGLQLDPRVYPKTDISAQQEFDEFLARFPSIGAQFRDAVPVRDWVKTDRLQFSSNACVGDRYCLMLHANGFIDPLFSRGLENTAVTIHALAARLIKALRDDDFSPERFEYIERLQQKLLDHNDDFVSCCYTAFSDFRLWDAFHRLWAVGTILGQFRLVQAHARFRASRNEGDLDHLDNDPPYLGYLCADMEEYYQLFNDAKAEVEAVSAGRKPADEAAARIHALIDERDFAKPMFGFGYCITGDKPQLNNSKYSLLPAMRLMYWTQTRAPAEVKKYFDYNPMFALLKAYITTRIGLALKK
What is the function of this protein?
Involved in the biosynthesis of the antifungal antibiotic pyrrolnitrin.  Catalyzes the chlorination of monodechloroaminopyrrolnitrin (MDA) at the 3 position to form aminopyrrolnitrin (APRN).
What are the official names of this protein?
Monodechloroaminopyrrolnitrin halogenase PrnC.
Protein: ISPH_FRAP2
Sequence: MKILLANPRGFCAGVSRAVETVEKVLEVEKSPVYVRHEVVHNKVVVDSLKKKGVVFVKEVDEVPDDAVCIFSAHGVSLQVEEAASKKNLVLYDATCPLVTKVHRGVRLASNNDAECVLIGHKGHPEVQGTMGQYRSEKGAIYLVESEQDVAKLDIKNPDNLYYATQTTLSVDETQGIIESLKNRFPNIKGPKKEDICYATQNRQTAIKSMLKEIDVLVVVGSQNSSNSNRLKELATLEGIDAYLVDNPADIKSTWFENKKVCGVSAGASAPEYLVQQVITEISRVCEGDVVVEEFDGIKEEVYFPLPRLLKQKIIGTN
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: GLBA2_OLIMA
Sequence: MKSLIVFACLVAYAAADCTSLNRLLVKRQWAEAYGEGTNRELLGNRIWEDLFANMPDARGLFSRVNGNDIDSSEFQAHSLRVLGGLDMCVASLDDVPVLNALLARLNSQHDSRGIPAAGYPAFVASAISAVRATVGARSFDNDAWNSCMNQIVSGISG
What is the function of this protein?
The extracellular giant hemoglobin is able to bind and transport oxygen and hydrosulfide simultaneously and reversibly at two different sites.
What are the official names of this protein?
Extracellular giant hemoglobin major globin subunit A2, Major globin chain a5.
What is the protein family that this protein belongs to?
Belongs to the globin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1346_MYCVP
Sequence: MARTDNDTWDLASSVGATATMVAAARAVATRAPRPVIDDPFAAPLVQAVGVDFFTRLATGELTTEELDTNDAESPVGMSRFADAMAARTRFFDDFFAEAMRAGPPPIRQGVILASGLDARAYRLSWPQDMVLFEIDQPEVLTFKAATLADLGVRPSTKLATVAVDLRNDWPAALAEAGFDASAPTAWIAEGLLGYLPPDAQDRLLDTIGELSAPGSRLAVESVPTHHEADQEELREKMKESSDRWRSHGFDVDFSELVFLGERADVTDYLRDRGWTVDATPTNQLLTRYGLAPLDSDEGFAEVVYVSATR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Mvan_1346.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: BCHL_METPB
Sequence: MNIAIRNPVPIRREEGSLQVALDPADRIETAKVFAVYGKGGIGKSTTSSNLSVAFSKLGKRVLQIGCDPKHDSTFTLTKRLAPTVIDALESVNFHSEELRPEDFVVEGFNGVKCVEAGGPPAGTGCGGYVVGQTVKLLKEHHLLEDTDVVVFDVLGDVVCGGFASPLQHADRALIVTANDFDSIFAMNRIVAAIHSKSKNYGVRLGGVIANRSAKTDEIDRFNAAVGLRRLAHFPDLDVVRRSRLKKSTLFEMEPSPELKAVTDEYMQLAETLWAGADPCEAVPMKDRDLFEFLGFD
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: OBP_VZVO
Sequence: MSPNTGESNAAVYASSTQLARALYGGDLVSWIKHTHPGISLELQLDVPVKLIKPGMSQTRPVTVVRAPMGSGKTTALLEWLQHALKADISVLVVSCRRSFTQTLIQRFNDAGLSGFVTYLTSETYIMGFKRLIVQLESLHRVSSEAIDSYDVLILDEVMSVIGQLYSPTMRRLSAVDSLLYRLLNRCSQIIAMDATVNSQFIDLISGLRGDENIHTIVCTYAGVGFSGRTCTILRDMGIDTLVRVIKRSPEHEDVRTIHQLRGTFFDELALRLQCGHNICIFSSTLSFSELVAQFCAIFTDSILILNSTRPLCNVNEWKHFRVLVYTTVVTVGLSFDMAHFHSMFAYIKPMSYGPDMVSVYQSLGRVRLLLLNEVLMYVDGSRTRCGPLFSPMLLNFTIANKFQWFPTHTQITNKLCCAFRQRCANAFTRSNTHLFSRFKYKHLFERCSLWSLADSINILQTLLASNQILVVLDGMGPITDVSPVQFCAFIHDLRHSANAVASCMRSLRQDNDSCLTDFGPSGFMADNITAFMEKYLMESINTEEQIKVFKALACPIEQPRLVNTAILGACIRIPEALEAFDVFQKIYTHYASGWFPVLDKTGEFSIATITTAPNLTTHWELFRRCAYIAKTLKWNPSTEGCVTQVLDTDINTLFNQHGDSLAQLIFEVMRCNVTDAKIILNRPVWRTTGFLDGCHNQCFRPIPTKHEYNIALFRLIWEQLFGARVTKSTQTFPGSTRVKNLKKKDLETLLDSINVDRSACRTYRQLYNLLMSHRHSFSQQRYKITAPAWARHVYFQAHQMHLAPHAEAMLQLALSELSPGSWPRINGAVNFESL
What is the function of this protein?
Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins.  In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication (By similarity).
What are the official names of this protein?
Replication origin-binding protein, OBP, OriBP.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae OriBP family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: PANC_STRCO
Sequence: MTTPTPPVLLRTAGELHARVRRGRRAVVMTMGALHEGHATLIRTARDIAGPDGEVVVTVFVNPLQFGAGEDLDRYPRTLDADLEIAGRAGADAVFAPAVDEVYPGGEPQVRVTAGPMGGRLEGASRPGHFDGMLTVVAKLLHLTRPDLALYGQKDAQQLALIRRMVRDLNFGVEIVGVPTVREEDGLALSSRNRYLSTAERRTALALSQALFAGLDRHAAQEALCARAREVPATQARAEALSALGESRAAADAHAVATSAPGSATAVRDAARLVLDDAARATPPLELDYLALVDPSDFTEIGDDHTGEAVLAVAARVGATRLIDNVHLTFGPLGAAS
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Z13_BOVIN
Sequence: DSTDGLLVKDKYLCGDLYGEEYGVIFPYLGLKTECLWTIKMDPLYRILLTVRDVHENCNKESLEIIEGPPESSNSRKICDTSHAEYTSCTNTMTVKYTRKPNHPAPDFFLIFRRVL
What is the function of this protein?
May be involved in the fertilization process.
What are the official names of this protein?
Spermadhesin Z13.
What is the protein family that this protein belongs to?
Belongs to the spermadhesin family.
What are the subcellular locations of this protein?
Secreted.
Protein: EFP_STRPS
Sequence: MIEASKLKAGMTFETADGKLIRVLEASHHKPGKGNTIMRMKLRDVRTGSTFDTSYRPEEKFEQAIIETVPAQYLYKMDDTAYFMNTETYDQYEIPVVNVENELLYILENSDVKIQFYGTEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATMETGLVVNVPDFIEAGQKLVINTAEGTYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSR3_HUMAN
Sequence: MGRRRAARGPGAEGGRPRHLPTRSLEAFAEEVGAALQASVEPGAADGEGGPGPAALPCTLAMWELGHCDPRRCTGRKLARLGLVRCLRLGHRFGGLVLSPVGKQYASPADRQLVAQSGVAVIDCSWARLDETPFGKMRGSHLRLLPYLVAANPVNYGRPYRLSCVEAFAATFCIVGFPDLAVILLRKFKWGKGFLDLNRQLLDKYAACGSPEEVLQAEQEFLANAKESPQEEEIDPFDVDSGREFGNPNRPVASTRLPSDTDDSDASEDPGPGAERGGASSSCCEEEQTQGRGAEARAPAEVWKGIKKRQRD
What is the function of this protein?
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable).  It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable).
What are the official names of this protein?
18S rRNA aminocarboxypropyltransferase, 20S S rRNA accumulation protein 3 homolog, HsTsr3.
What is the protein family that this protein belongs to?
Belongs to the TDD superfamily. TSR3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLO2_ENT38
Sequence: MNLISIPAFQDNYIWVLADDKDRCVIVDPGEAAPVLKAIEENGWQPEAILLTHHHNDHVGGVPALCAKFPHLEVYGPQETQNKGTTCVVDEGQNVLILEWEFSVFATPGHTSGHICFYSSPYLFCGDTMFSGGCGRLFEGTPEQMYQSFQKINALPEETIICCAHEYTLANMKFAASILPEDRAIQDYYHKVKELRAKNLSTLPVILKNEREINLFLRTDDIDLINKINQETKLQQPEQRFAWLRSKKDNF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: YL786_MIMIV
Sequence: MDFNILYSFVSNKTFTDVEIVLIDEINRVNMNVHKAVLASSSQYFLNLFTKFSETNKSTITIRVRDSQISSDIICSFYGQIVDSTNYPDWKYTLLKYQCLDYFSLDYNIDILTGLKIPSEGFDLLLETANTIGYRNEINKLIAKNIPDNYDLSIFSDEFLGSLRKYICKHNIITANFKSINIYDVITGNKLSSLSLNNNFSHVCKVGKNIIAIVYYCADKIFLFDLVSRDVIDTLHNLDIQSSCDMTAICYIKSLNHLVTANSNNQLIVWDLTTRQIIKIKKVNRLINRLIANHTIITDYNLFISIGYNESILVWDKNYTISKGIDSPNKITTYSASGRELILANARYIKIFDIDEGKILYKTNNDTFRTPYDIINICDNSYILFDSDNEPICYLIYDWKNVSKIRLNRSKKNYDNIFCKKFPPESVNYSANDTNSNILIVVTDYHTVYAQINGKKYGPFVVKPNNIAGVFFVKDKKATNLLNSINDLIKHN
What are the official names of this protein?
Putative BTB/POZ domain and WD-repeat protein R786.
What is the protein family that this protein belongs to?
Belongs to the mimivirus BTB/WD family.
Protein: HISX_HALSA
Sequence: MEYEAVADLAPDRRVALFERDAGVDAVRSDVAEILDRVESEGDVALRALASEFDDVEVGNLDVTDEMERAADAVPDDVYDAIEDAAANIRAFHEAQLPDDWRESFAAGRELGRRFRPVRRVGVYAPGGTAAYPSSVLMGVIPAVVAGVEQVAVATPPAETINPVTLAAAHAAGADRVYQVGGAQAIGAFAYGTETVDTVQTVVGPGNKWVTAAKAEVRGDVEIDFLAGPSELLVVADETAEPAFVAADLLAQAEHDPNASVVAVTDDEATAAAITDAVAARLDDRERADTIRAALDNEASGVFVARSMSEAVMFAEEYAAEHLSIQASDDEALLDRIDSAGSVFLGGYAPVAAGDYAAGTNHVLPTNGTARVTGGLSVDTFLRSTTVQRLDREGLAALRETVTTLADAEGLEGHAASVDARFEDE
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: INSD6_ECOLI
Sequence: MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI
What is the function of this protein?
Involved in the transposition of the insertion sequence IS2.
What are the official names of this protein?
Transposase InsD for insertion element IS2K.
Protein: EDNRB_RAT
Sequence: MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
What is the function of this protein?
Non-specific receptor for endothelin 1, 2, and 3.  Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Endothelin receptor type B, ET-B, ET-BR, Endothelin receptor non-selective type.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=internalized after activation by endothelins.
Protein: RL21_CHLT3
Sequence: MRALVEISDKQFFVTEGEKLFVPTQKAEAGDTLTFEKVLLQSDGAAASLSPSCKVTAKLLRHIKGDKVTVFKKKRRKRYRVTRGHRQGFSEIEILSVA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: BGAL_KLEP3
Sequence: MQISDTGHSHMPDFHAVLAREDWQNQTITHLNRLPAHPAFASWRDELAARDNHLSTRRRQLDGEWQFVYARSPFAVDAQWLTQDLPDSRGTPVPSNWQMEGYDAPIYTNVRYPIDTTPPRVPEDNPTGCYSLHFTVEDTWRENGQTQIIFDGVNSAFHLWCNGVWVGYSQDSRLPAAFDLSPFLRPGDNRLCVMVMRWSAGSWLEDQDMWRMSGIFRSVWLLNKPQQRLCDVQLTPALDALYRDGTLQVQATVEATEAALAGLSVGVSLWRGEEQVAAGRQPLGTPAVDERGHYAERVDFALAVTAPAHWSAETPNCYRAVVTLWRGDELLEAEAWDIGFRRIEIADGLLRLNGKPLLIRGVNRHEHHYLRGQVVTEADMVQDILLMKQNNFNAVRCSHYPNAPRWYELCNRYGLYVVDEANIETHGMVPMNRLSDDPAWLPAFSARVTRMVQSNRNHPCIIIWSLGNESGGGGNHEALYHWLKRNDPSRPVQYEGGGADTTATDIICPMYARVERDQPIPAVPKWGIKKWISLPGEQRPLILCEYAHAMGNSLGNFADYWQAFREYPRLQGGFIWDWADQAIRKIFDDGSVGWAYGGDFGDKPNDRQFCMNGLVFPDRTPHPSLVEAKHAQQYFQFTLLSTSPLRVRITSEYLFRPTDNEVVRWQVQSAGETLYHGNLTLALPPEGSDEITLLDSLILPEGARAVWLTLEVTQPRATDWSEADHRVAWQQFPLPAPLALPAPTVPAGAPDLIVSDEVWQIRAGSQCWTIDRRTGLLSRWSVGGQEQLLTPLRDQFIRAPLDNDIGVSEVERIDPNAWVERWKSAGLYDLEAHCVQCDAQRLANETLVDCRWHYLRGEEVVIVSHWRMHFTADGTLRLAVDGERAETLPPLPRVGLHFQVADQQAPVSWLGLGPHENYPDRRSSACFARWEQPLAAMTTPYIFPTENGLRCDTQALDWGRWHVSGHFHFSVQPWSTRQLMETDHWHKMQAEDGVWITLDGLHMGVGGDDSWTPSVLPQWLLSQTRWQYEFFLRCL
What are the official names of this protein?
Beta-galactosidase, Beta-gal, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: FA11_HUMAN
Sequence: MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
What is the function of this protein?
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
What are the official names of this protein?
Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: A2MG_PASMU
Sequence: MNKQYFLSLFSTLAVALTLSGCWDKKQDEANAIQFNVNPIEITNYDETPKEVYPLVISFSGPAAPITSVNKELTQGISIEPALKGKWVWNSDTLLSFKPETDWPTGQDYRVKIDKKILNPQLHYTQKLNEPVVFKTPEFKATLVEQYFHQDPTQAQVRHAIFKLSFTHPVDRQKFEKALQVNLVRKNNDNTQNILSPLKFNVRYGEKDLVAWVNSDNVALAQSDNQYIEVKIDKNLTALLGNNSLETDIISSVKVPTKYSLDFSTGILIAQNEKNEAEQVLHLNFTHSIKGNELEKHISAYLLPEFTPENHPHWRYNLISRDVLQHAVAVPLQRLATETTYANQQSFKLDIPEKRCLYIEVQNKITALGGYEMKGALGDLACAPDYPKYVGFVGKGSILSSIGERKVTIATRNFTKVKLEIGRIQEEQLRHLIALNQGNFQNPDLGQLKIDNIADFFTKNYTLNNKKPQETTYLGIDLEKIVKQAEPAMGIYWLKVTGDSDNPNSTLRDTSQHMDWRNDASNQFSDYRLIVISDLGVIAKKAVDGTQSVFVQSISRGEPVEGATVSVISRNGSIIKSDYTNEQGVVNFSSLAHFKQELAPVMYLVSTQESLSFLPIDKYDRNLDYSRFDVGGIYASENAASLKAYLFNDRGIYRPNETLHTGIITKAQDWQLALNNIPLQFNLYSPSGMLMHKQTIRLEKSGLNSVSFTLPETAETGEWFAELLVTEKNNQTEIGSMTFQVQEFQPDNLKIKTTFNQAHAEGWVAPQDLVATVQLANLFGTPAQNRKVQANLTLQPLLPKFSQYADYRFFDNQRNKSAILYETELNEQVTDKEGKAHFPIDLTQYAENTAQMLYFTADGFENDSGRAVSTVKSVMVSAQPWLIGYQTKNDLAYLKRNTPAVVNFIAVNPKLEKVAVEHLKATLLERKYVSVLTQQASGAYKYESKLIENEIEQTTLQINATGTDFTLNTGKSGDYVLVLSNEHDQEVNRIHYAVIGNQNVSVAMDKNTELKLRLNKKQFKPHEEIEIAIHAPYAGTGLITIESDRVYAHKWFKATTNSSVQRIQLPENFEGTGYVNVQFSRDIHSDDIFTSPLSYGVVPFTVNVDNRRLKLQLDSPKKVKSGETVEFKLSSDKPSKALIYAVNEGILQVAGYQFTDPLSYFFPKYALQVQTAQILDLILPEFSKVMQFAQTGGDADMNMELAMKMAMANMNPFKRKTDKPVAYWSGIVDIHGEKTVSYQIPEEFNGNLKVMAIALSHDGKHLGHVATETLVRNDLILSPTVPLTLTPGDESEINVVIANNTNKAQRVNLKATLEPQLSFIGEAEKVIDIAPMSESRADFVIKATQELGSSTIRFIASYEDAQQQKVDAVRHVTLSVRPIMPKQFATQIQKVAAGKTVTSPLPMTLFPQHRQQSALFSAAPLALAQGVSTYLTHYDNYCTEQMISAAMPMVLFSKNPAYQPLLTALSRKAPQNVGSTGTHDTLEKAFKLLPSRQTEYGNYGIWNNVEEGNLFVTAYVAHFLIEARERHLVLPKAWFGQHGLFNNTISALEEQSVPQEGDSLATLRQRAYSAYLLTRLAKVPSNALLSIRTQLEQQFSAEEWQKDTVSAWLAAAYHMLKQDNEANKLIEPVINQLVAARPAQWTYDAYSDPLIKDSTMLYVIARHFPAQLSKVSDSVLERIVQDLNQQRYNTLSSSMVLLALDAYAQQHQSELANLQIQHQGKEISQSTPLFRFADLADTQMDISFVNNSQQPAWFALSQVGYPQNAAQQALSQGLEVDRSYTDKEGKPIRQVKIGDVIYVTVKIRASTDYVSDVIITDLYPAGFEVLWQQGAEDDFEDSWLAQHTELREDRLLSYLDAEKEMKVLKYQLKAVNIGTFQIPPIYAESMYDRAIKAYSASEGQIKVRK
What is the function of this protein?
Protects the bacterial cell from host peptidases.
What are the official names of this protein?
Alpha-2-macroglobulin.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RBFA_THESQ
Sequence: MNPAYRKAMLESEIQKLLMEALQQLRDPRLKKDFVTFSRVELSKDKRYADVYVSFLGTPEERKETVEILNRAKGFFRTFIAKNLRLYVAPEIRFYEDKGIEASVKVHQLLVQLGYDPLKDKEKKEEEKKEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_ZYMMO
Sequence: MPELPEVETTIRGLSEVLMGEKIIDVKVRRASLRRPIPSDIQERLIGSTIISLSRRAKYGIIVNDRDDALIFHLGMSGRWKINPENFEKHDHFVLQTKNNFIVSLYDPRRFGSLDLVKKNQLLEWSYFRNIGPEPLTGNFNPEYLQKKLFSSSAPIKKILLDQKVVAGIGNIYACEALHQAKIHPQRPSKNLNFDEITSLVFSIKNILQKAIAEGGSTLKDYARPNGELGYFSTKFKVYGKEGEQCECGHTIERYTLGGRSTFLCSSCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: BTLA_HUMAN
Sequence: MKTLPAMLGTGKLFWVFFLIPYLDIWNIHGKESCDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSNLIESHSTTLYVTDVKSASERPSKDEMASRPWLLYRLLPLGGLPLLITTCFCLFCCLRRHQGKQNELSDTAGREINLVDAHLKSEQTEASTRQNSQVLLSETGIYDNDPDLCFRMQEGSEVYSNPCLEENKPGIVYASLNHSVIGPNSRLARNVKEAPTEYASICVRS
What is the function of this protein?
Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050).  May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044).  In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.  In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).
What are the official names of this protein?
B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: DNAJ_RICPR
Sequence: MSQDYYQVLGVSKTASQADIKKAYLKLAKQYHPDTTNANDAEKKFKEINAAYDVLKDEQKRAAYDRFGHDAFQSQQARGGGNNGSFHPDINDIFGDFFSDFMGSGRRKQTSSKIRGSDLKYDLTIKLEEAFHGIEKNISFSSEVKCDTCHGTGSEKGETITTCDACGGVGATRIQQGFFTLEQTCHKCQGNGQIIKNPCKKCHGMGRYHKQRNLSINIPAGVENGTRIRHTGEGEAGIRGGNNGDLYVDIAIKPHDIYKVDGANLHCKLPISFVHAALGGEIEVPVIEGGKVKLTIPAGTQNGDQLRLRSKGMSKVRSTIRGDMLTHIHVEVPKNLSKKQRELLEEFKKESINEKENDSSFFNKMKSMWS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.