PharMolix/UniProtQA huggingface dataset:
Protein: MSHC_MYCMM
Sequence: MQSWSSAPVPIVPGRGPELRLYDTADRQVRPVAPGNTATMYVCGITPYDATHLGHAATYLAFDLIHRLWLDLGHEVRYVQNVTDVDDPLFERADRDGVDWRDLAAQEVALFREDMAALRVLSPHDYVGATEAVAEIIELVEKLLASGAAYVLDGEHPDVYYRSDATLQFGYESGYDRDTMLGLFEQRGGDPGRPGKNDALDALLWRAARPGEPSWPSPFGPGRPGWHIECAAIALSRVGSGLDVQGGGSDLIFPHHEFTAAHAECVTGERRFARHYVHAGMIGWDGHKMSKSRGNLVLVSGLRAEGVNPAAVRLGLLAGHYRADRFWSQQVLDEAVGRLQRWRAATTLPAGPDAAAVVARVRQYLADDLNTPKAIAALDGWATDALDYGGHDEVAPRLVASTIDALLGVDL
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: NOP1_CAEEL
Sequence: MSAPKKRKSDIHSDDRDHADHQTKKEKHWFEEKSEQNGENRRSSIFKGFLKKVKSSTTLKSTNKSASSSKMDTIANETHLSITSESSITSVESCHSAQFPNVAKNAMLRTLVNRDSFTPVPPPDGESVTFILPEIGSSKLEFTSKMDDAISIESRMSIGSCHTIDEDSASIGSTSVFCTPSRNPLMRNGLRMSTRSVPENQDDMPPALFRSLCNSAVRRVPTSKSEGGGTPMRRSMRMSIQKRNLSSKNMEDVPEEEALTVSNSSIRVDAPIAEEDEEVFGAAKEYFDNNVTSHNDSADEGTCSMSRLSTTSERASGVGGSSIFQGRRSSIFRKIFPGKSESKDRRMSDNNQASEQYMDKKSRRASVVSFNEFTSVSGLSVNDSASKNPKDLTESPQQPKLRKKTASSSNLSQRISSVFRMGSNSTVKLNEYVPSPIVSQSSRRNTLTGNSSISSGVGSIASGTSDQGYGTIGSRSGQSISRCGSRRDDEGKKERTRRLLDRIIISDVPAGELLKLKIEQVKKQKQLEMDELFETQLTESSSSDTSQSENLQFDVVAVDIKADGSPFSTTAATFMDSELSKRVKEEIVSNYRPDRCGSITEYEPELVFVMPEQPQASLKSLNDSVSSNADINLDHLRNVRSGLCKSIEEWKRITKMRESSTMLIYPMFCQSEEEWDSKGTIDAIFLMLDGILMNTKRWMPNGKCILAGVTPNNVILLRNKFDELKLSVAISESDGPASSNDDFDTQSTASTSTVFGAKI
What is the function of this protein?
Required for formation of the pseudocleavage furrow during the first cleavage of the embryo and also mediates aster-induced furrowing during cytokinesis.  Promotes cortical recruitment of ani-1 and nmy-2 during pseudocleavage and cytokinesis and promotes the accumulation of actin at furrowing regions.  Regulates establishment of embryonic cell polarity.
What are the official names of this protein?
Pseudocleavage protein nop-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cell cortex. Cleavage furrow. Note=Highly concentrated in interphase nuclei. As well as a significant cytoplasmic pool, a distinct cortical localization is also detected, particularly at ingressing pseudocleavage and cleavage furrows.
Protein: PSBY_TRIV2
Sequence: MDIDFRVAIVLAPIAVAAGWAAFNIGAAAIRQVQNFLNREA
What is the function of this protein?
Manganese-binding polypeptide with L-arginine metabolizing enzyme activity.  Component of the core of photosystem II.
What are the official names of this protein?
Photosystem II protein Y.
What is the protein family that this protein belongs to?
Belongs to the PsbY family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: HIS6_SHIFL
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVEEVQKRGAGEIVLNMMNQDGVCNGYDLKQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRIC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_WOLPP
Sequence: MKSISCSKEYSEDVRNLNIRPEQLDDFVGQKDLIQNLKVFINAAQTRAEALDHVLLYGPPGLGKTTLAQIVSKELRVSFRATSGPLLSKAGDLAAVLTTLNAKDVLFIDEIHRLNRSIEEVLYTAMEDFCLDILVGEGPSTRTLRIDLPPFTLIGATTRLGLLSAPLRDRFGIPLHLEFYSFEELVDIIKRGARVLCAEIEKDAVQEIACRARGTPRIALRLLRRIRDFVEVKDDKKITCEIAGSALSKLGIDKMGLNKLDMDYLRFLFNTSGPVGIDTISIALSEDVGNIEETVEPYLIKVSFVKRTPRGRVLTDQAREYLSINSVVC
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ZBT7C_MOUSE
Sequence: MANDIDELIGIPFPNHSSEVLCSLNEQRHAGLLCDVLLVVQEQEYRTHRSVLAACSKYFKKLFTAGSLASQPYVYEIDFVQPEALAAILEFAYTSTLTITASNVKHILNAARMLEIQCIVNVCLEIMEPGGSVGEEDDKEEEDEDDDDEDEDDEEEEEEEEEEEEDDPEDFADQENLPDPQDITCPQSPSKTDHLTEKDYSDTPRDFPDSFQPGSPGHLGVIRDFSIESLLRENLYPKANIPDRRPSLSPFAPEFFPHLWPGGFGAFAQLPEQPMDSGPLDLVIKNRKIKEEDKEELAPPPPPPFSSDFFKDMFPDLPGGPLGPIKAENDYGAYLNFLSATHLGSLFPPWPLVEERKLKPKASQQCPICHKVIMGAGKLPRHMRTHTGEKPYMCSICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGVRPYQCEFCYKSFTRSDHLHRHIKRQSCRMARPRRGRKPAAWRAASLLFGPGGPSADKAAFVMPPALGDVGGHLGGTAVCLPGPSPAKHFLASPKGTLSLQELERQFEETQMKLFGRAQLEAERNAGGLLALALAENVAATRPYFPLPDPWAAGLAGLPGLTGLNHVASMSEANN
What is the function of this protein?
May be a tumor suppressor gene.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 7C, Zinc finger and BTB domain-containing protein 36.
Protein: RL21_SULIL
Sequence: MVKHSRGYRTRSRSLLRKSPRERGAVPSLSRLMVEYKEGDKVVIKINPSVHSGMPHRRYQGKVGKIIGKRGRAYLVSVTLGDKEKVIIVRPEHLVSFSSSG
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: GCSH_MICLC
Sequence: MSSIPEGLKYSAEHEWIAEAGAAGTVRVGITDFAQDALGDVVYVDLPEVGTEVTAGTAVGEVESTKSVSDIYAPVSGTVAAVNDELDGEPGLVNSAPYEGGWLFEITLADEAQLEGLMDAEGYASHTS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: UBIA_COXBU
Sequence: MINLRQQMPHYLRLMRFDKPVGIFLLLWPTLWAVWIAAKGAPSFKIAVIFIAGSVVMRAAGCIVNDFADRHLDKHVQRTQMRPLASGSVSVTEAMLLFAVLSLIAFTLVLLLNRLTVELAVIGILLALVYPFLKRFTHLPQLWLGVAFSWSIPMAFAATVGHVPAVAWLLFFAAVLWPIVYDTQYAMIDREDDVKVGIKSTAILFGRYDRLMIGLLQGSVLLTFGLLGWYLRFNYWFYLGLLVALGLMCYQQFLIRHRKPPDCFAAFRNNNWVGFFIFLGILLTYRN
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSTB1_STRP8
Sequence: MTEPILQIRDLSVYYNQKKTLKDVSLDLYPNEITALIGPSGSGKSTLLRSINRMNDLNPEVTITGSIVYNGHNIYSPRTDTVDLRKEIGMVFQQPNPFPMSIYENVVYGLRLKGIRDKSILDHAVESSLKGASIWNEVKDRLHDSAVGLSGGQQQRVCIARVLATSPRIILLDEPTSALDPISAGKIEETLLLLKKDYTLAIVTRSMQQASRLSDRTGFFLEGDLLECGPTKAMFMNPKRKETEDYISGKFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y3666_YERE8
Sequence: MKRTQNINQETFRKSWRSYRLAPVALAISAVFMLAGCEKTDETVSLYQNADDCSAANPSKSAECTTAYNTALQEAAKTAPKYATREDCVAEFGESQCTQAPAQAGMVPTSSSSSETTAAAPQQSGSMWMPLMAGYMMGRMMGGGASQPLFTSKAPNSPANGKFVDATGKNFGSATTGRTMTVPRTAMAPKPAVTNTITRGGFGESVAKQSSMQRSAATSSKTSTRSMGG
What are the official names of this protein?
UPF0441 protein YE3666.
What is the protein family that this protein belongs to?
Belongs to the UPF0441 family.
Protein: NMRL1_MOUSE
Sequence: MADRKLVVVFGATGAQGGSVARALLEDGTFRIRVVTRNPEQRAAKELKQQGAEVVRGDQDDAASMELALAGAHATFIVTNYWETCSQDREVQQPHQWDQVFKQGKLLADLAKRLGLHYVVYSGLENIRKLTAGKLAAGHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSYFLPQKAADGKSFLLDLPMGDVPMDGMSVSDLGPVVLSLLKKPEEYVGQNIGLSTCRHTAEEYAALLSKHTGKAVHHAKTTPEDYEKLGFQGAQDLANMFRFYTLKPDRNIHLTLRLNPKAQTLDQWLEQHKGDFAQL
What is the function of this protein?
Redox sensor protein.  Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels.  At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis.  Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis.  Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1.  The homodimer binds one molecule of NADPH.  Has higher affinity for NADPH than for NADP(+).  Binding to NADPH is necessary to form a stable dimer (By similarity).
What are the official names of this protein?
NmrA-like family domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios (By similarity).
Protein: ARGJ_THENN
Sequence: MFVPRGFSYAGVHCRIKRKRKDLGIIFSEVPCTAAGVFTTNVVKAAPVIYDMEILGKNPSGIRAITVNSGVANACTGEQGMINARRMAEKTAKELNIPVESVLVSSTGVIGVQLPMEKVESGIEEAVKNLSKDPVPFAEAIMTTDTKIKIHSKKVTIEGKEITVLGIAKGSGMIHPNMATMLSFITTDANVSEDALKKLLKISVDDSYNMIDVDGDTSTNDMVIILANGLAGNAPIQEETDGFWKLYEAVHEVNQVLAEKIVEDGEGATKVIEVEVRNAPDRNSARLIARAIVSSNLVKTAIYGEDANWGRVIAAAGYSGAQFDPDRLDLFFESAAGRIKVAENGQGVDFDEDTAKKILSEKKVKIILDMKQGKELARAWGCDLTEKYVEINGRYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCAL_LACJO
Sequence: MSVIGIVAEYNPFHSGHEFLMNQARLAAKNDPIIVVMSGNYVQRGQMAIMDKWQRAKAALASGADLVFELPFSFAVQPADIFANGSIKMLSDLGVSELFFGVEDANLNFSYLGQKINQIPKNRMDFRDYTQTYATQYNEMVAREVGHEVNQPNMMLAVAYAVASEQLKNPLHLHPITRVGSGHDDPLLQDKIVSSATAIRNYCLHHPNDLSELKKYLPKGELVSLESQKVYPNWNLLFSFLKYRIESASLEELQSIYQMSEGLEYKMKEEIHTAEDFTSFLRQIKSKRYTYARLRRLCLYTLLNVTENEIKDSYQDVSTLLLGYSSRGRNYLKKIRKDVQVPIISKVDKKNAASGTLGLQVKVDRLFEQIIGEDQNFGRKPIEVK
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_THEP1
Sequence: MRIDTVNVLLEALPYIKEFYGKTFVIKFGGSAMKQENAKKAFIQDIILLKYTGIKPIIVHGGGPAISQMMKDLGIEPVFKNGHRVTDEKTMEIVEMVLVGKINKEIVMNLNLHGGRAVGICGKDSKLIVAEKETKHGDIGYVGKVKKVNPEILHALIENDYIPVIAPVGIGEDGHSYNINADTAAAEIAKSLMAEKLILLTDVDGVLKGDKLISTLTPDEAEDLIRDGTVTGGMIPKVECAVSAVRGGVGAVHIINGGLEHAILLEIFSRKGIGTMIKELEG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMK_BACSU
Sequence: MNELKLSKRLQTVAEYIPNGAVMADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKSGLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNIHAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFLAKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG
What is the function of this protein?
Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 22 (m1A22) in tRNA.
What are the official names of this protein?
tRNA (adenine(22)-N(1))-methyltransferase, TrMet(m1A22), tRNA(m1A22)-methyltransferase, tRNA(m1A22)MTase.
What is the protein family that this protein belongs to?
Belongs to the TrmK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y748_DESPS
Sequence: MSRICYLDCFSGVSGDMLLGAFLDAGVEVAALEAGLAALHLDDLILRTKRVEDCGLSAIKVDVDSSRRQNLRTLPDLLRILQESDLSSLVQERAALVFTAIASAEAKVHGTSLEQVHFHEIGALDTIADVVGVVLCLELLQIDQLVCSPLPQPRGFIDCAHGRIPLPAPAVCEILRGVPSYGVALEQELVTPTGAALVKALVGAFGQFPPMQQLAVGYGAGSQRLANGQPNLLRIFVGTPDDVLEEQQVEVIETNLDDWNPESYPYLCERLFEHGALDVSLAPIQMKKGRPGFCLQVIAGREDSAQLKDIVLLETTALGLRFRFEYRRTLPRRELHIESPWGTMRVKEVQRGGRRVIIPEYEECRRVAGEYDLPLQEVYGRIQGLNFYE
What are the official names of this protein?
Putative nickel insertion protein.
What is the protein family that this protein belongs to?
Belongs to the LarC family.
Protein: RTXC_KINKI
Sequence: MDKFSELGSIAWLWTNSELHQNWPLSLFSTNVIPAIETQQYVLLVRDGMPIAYCSWARLNLETEVKYINDVTSLKLEDWQSGDRYWFIDWIAPFGDSYLLTKHMRKLFSDGLFRAIRVDAGSPNGKISEFYGRNVDAKLAMQSFEQYQKELMNALSQQDNFIISTSK
What is the function of this protein?
Protein-lysine myristoyltransferase that catalyzes myristoylation of the protoxin (RtxA) at two internal lysine residues, thereby converting it to the active toxin.
What are the official names of this protein?
Protein-lysine myristoyltransferase RtxC.
What is the protein family that this protein belongs to?
Belongs to the RTX toxin acyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GYRA_STAAC
Sequence: MAELPQSRINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELEAILADEEVLLQLVRDELTEIRDRFGDDRRTEIQLGGFENLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRAQNRGGRGVQGMNTLEEDFVSQLVTLSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPVVNAIELENDEVISTMIAVKDLESEDNFLVFATKRGVVKRSALSNFSRINRNGKIAISFREDDELIAVRLTSGQEDILIGTSHASLIRFPESTLRPLGRTATGVKGITLREGDEVVGLDVAHANSVDEVLVVTENGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGVIIRLDVADISQNGRAAQGVRLIRLGDDQFVSTVAKVKEDAEDETNEDEQSTSTVSEDGTEQQREAVVNDETPGNAIHTEVIDSEENDEDGRIEVRQDFMDRVEEDIQQSSDEE
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUN_RALSO
Sequence: MHRCMPLVAASMAALMLAGCGGGDGDTTLSTAAATDTTTLKTAATTSISPLWLTIAKDSAAFTVSGTRTVRYGAGSAWVAKSMSGTGQCTAAFFGKDPAAGVAKVCQVAQGTGTLLWRGVSLAGAEFGEGSLPGTYGSNYIYPSADSATYYKNKGMNLVRLPFRWERLQPTLNQALDANELSRLTGFVNAVTAAGQTVLLDPHNYARYYGNVIGSSAVPNSAYADFWRRVATQFKGNARVIFGLMNEPNSMPTEQWLSGANAALAAIRSANASNVVFVPGNAWTGAHSWNQNWYGTPNGTVMKGINDPGRNLVFEVHQYLDGDSSGQSASCVSATIGAERLQDFTNWLRSNGYRGFLGEFGAASNDTCNQAVANMLTFVKNNADVWTGWAWWAGGPWWGGYMYSIEPSNGVDKPQMSVLAPYLK
What are the official names of this protein?
Endoglucanase, Cellulase, Endo-1,4-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: CRLF2_HUMAN
Sequence: MGRLVLLWGAAVFLLGGWMALGQGGAAEGVQIQIIYFNLETVQVTWNASKYSRTNLTFHYRFNGDEAYDQCTNYLLQEGHTSGCLLDAEQRDDILYFSIRNGTHPVFTASRWMVYYLKPSSPKHVRFSWHQDAVTVTCSDLSYGDLLYEVQYRSPFDTEWQSKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDACAETPTPPKPKLSKFILISSLAILLMVSLLLLSLWKLWRVKKFLIPSVPDPKSIFPGLFEIHQGNFQEWITDTQNVAHLHKMAGAEQESGPEEPLVVQLAKTEAESPRMLDPQTEEKEASGGSLQLPHQPLQGGDVVTIGGFTFVMNDRSYVAL
What is the function of this protein?
Receptor for thymic stromal lymphopoietin (TSLP).  Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5.  Also activates JAK2 (By similarity).  Implicated in the development of the hematopoietic system.
What are the official names of this protein?
Cytokine receptor-like factor 2, Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLP receptor.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 5 subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single- pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: PAM17_GIBZE
Sequence: MASPLKTFVLRMPATGLVRSSPKASFSTISAARPASCLSRSPFRKQCFKPAISINKSFSRAVSDKPQPETVQATPQPAPSNVLPPLDWNSFFKLRVKRRRYQMLFSITNGIFAGSGGAIFLSTGSAEPIISQIPLDPFMTLGLMTLAFSGLGWLSGPSVGNQVFYILNRQWKKQMTQKEAIFFERIKRNRVDPTNSSANNPVPDFYGEKISSVAGYRSWLKDQKAFNKKKTANFV
What is the function of this protein?
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
What are the official names of this protein?
Presequence translocated-associated motor subunit PAM17, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PAM17 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GLMU_NOSP7
Sequence: MVVVAILAAGRGTRMKSRLPKVLHSLGGQSLVERVIESVEPLSPSRRIVIVGYQSEEVQTAMHSIPNLEFVEQTVQLGTGHAIQQLLPHLKDYTGDLLILNGDLPLIRSETLKQMLQTHAQNQNAATILTSHLPDPTGYGRVFCNNENIVQQMVEHKDCTAAQRQNQRINAGVYCFRWPDLAKVLPHLQANNAQKEYYLTDAVTQVGQVMAVDVEDNQEILGINDRLQLATAYEILQKRVKEKWMLAGVTLIDPASITIDETVELQPDVIIEPQTHLRGNTVIQTGSHIGPGSLIENSQLAENVTVQYSVVIDSTIQAGSRIGPYAHLRGHVQVGAGCRVGNFVELKNTQLGDRTNAAHLSYIGDTVVGNQVNIGAGTITANYDGVKKHRTKIGDRTKTGANSVLVAPLTLGDDVYIAAGSTVTEDVPNDSLVIARSRQVVKPAWQRKSVENKTTDQHK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_YERPN
Sequence: MSLDIAKYPTLALAENPEELRMLPKESLPKLCDELRQYLLTCVSRSSGHFASGLGVVELTVALHYVYNTPFDHLIWDVGHQAYPHKILTGRRDRISTIRQKDGLHPFPWRGESEYDVLSVGHSSTSISAGLGMAVAAEREGKGRRTVCVIGDGAITAGMAFEAMSHAGDIHSDMLVILNDNGMSISENVGGLNNHLAQLLSGKLYASLREGGKKAFSALPPIKDLLKRTEEHLKGMVVPSTLFEELGFNYIGPVDGHDVHTLTQTLKNMRDLKSPQLLHIMTKKGKGYAPAEKDPIGWHAVPKFDPASGTLPKSQSSLPTYSKIFGEWLCETAAKDSKLMAVTPAMREGSGMVRFSREYPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQLIHDVAIQNLPVLFAIDRGGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYHHNGPAAVRYPRGNGTSAVLEPLEMLPIGKGVLRREGEKIAILCFGTLLAQAQLAAENLNATLVDMRFVKPLDEELVLEMAAKHQVLVTVEENAIMGGAGSGVNELLMAKRRWVPVLNIGLPDLFVPQGEQDEMRSELGLDAAGIQRQIEAWLA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: OSTCB_XENLA
Sequence: MESLYRIPFTVLECPNLKLKKPSWLHMPSAMTVYAMVVVSYFLITGGIIYDVIVEPPSVGSMTDEHGHQRPVAFLAYRVNGQYIMEGLASSFLFTMGGLGFIILDRSNAPNIPKLNRFLLLFIGFVCVLLSFFMARVFMRMKLPGYLMG
What is the function of this protein?
Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Oligosaccharyltransferase complex subunit ostc-B.
What is the protein family that this protein belongs to?
Belongs to the OSTC family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.