PharMolix/UniProtQA huggingface dataset:
Protein: NUBP1_ANOGA
Sequence: MSSGADVPSDAPAHCPGTQSDDAGKASACAGCPNQQLCATGPKGPDPAIALVRQKLADVRNKLLVLSGKGGVGKSTVTALLSRAMAHRNPDENFGVLDIDICGPSQPRVLGVLGEQVHQSGSGWSPVYIEDNLSLMSIGFLLGSPDDAIIWRGPKKNGMIRQFLTEVDWGQLDYLVLDTPPGTSDEHLSATTFLKGTDGSWGAVLVTTPQEVALLDVRKEISFCKKLAIPVVGVIENMSAFVCPKCTTETRIFPARTDGGGAEQMCIEMEVPYLGQLPLDPRLTKCCDEGKDFITEFPTSPAVVALEEIVTKVRQFFGDGKGERQ
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NUBP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETB_XANC5
Sequence: MPRFSDQLLYIGGRYVPARGGHTFEVVNPATGEVLANVHNAGADDLDAAVDSAQAGQRQWAALTTVERSRILLRAVALLRERNDALAELETLNTGKPLSETRSVDVVTGADVLEYYAGVAQALQGAQVPLREGSFFYTRHEPLGVVGAIGAWNYPIQIALWKAAPALAAGNAMIFKPSEVTPLTALKLAEIFTEAGLPDGVFNVLPGDGASVGTALTEHPQIEKISFTGGTATGRKVMASASSSSLKEVTMELGGKSPLIVCADADLDLAADIAMMANFYSSGQVCTNGTRVFVPRALRHAFEARLLARVQRIHIGDPLDERTTFGPLVSAAHMQRVLEHIEQGKAEGARLLCGGERLQDGALAQGYYVAPTIFSDCTDVMTIVREEIFGPVLSLLTYDDEDEAVTRANATTYGLAAGVVTPDLARAHRLIHRLEAGICWVNTWGESPAPMPVGGYKQSGVGRENGLATLQAYTRTKSVQIELERYASVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: DXR_BIFLD
Sequence: MSIASNSTVIILGSTGSIGTQGLDVISRHPERFTVTGLAAGGAHIELLAQQAAQFHVSEAAVFDETKVPALQAALAQAGAQGVRVTGGPDSVIAMAGSGANVVLNGITGSIGLEPSIAALKAGSQLALANKESVVAGGHLLFSAQVRENQINPVDSEHSAIWQSLRSGTHAEVAKLVVTASGGPFRGWKRADMENITPEQALHHPTWNMGPVVTINSSTLMNKGLEVIEASRLFNVPPERIDVTVHPQSIVHSMVEFVDGATICQASPPDMRLPIALGLSAPDRMTNVAAACDWTQAATWTFEPLDDEAFPAVQLARHCLAASEKHTAVLNAANEQAVHAFLEHRLPYLGIVDTVKAVLDQMDAELRGNPLFTDVEEMNQLELEARRRADDLINKQ
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: XPT_LACCB
Sequence: MKLLEDRIKKDGQVIGTDVLKVDNFLNHQVDPDLMADLGHEFYRRFSNEPITKILTVESSGIAPAIATAMEFHKPLVFARKHKSLTLKDHLYTATVYSFTKKTSNEIAISRKFLSADDNVLIIDDFLANGQAVEGLMDIIAQAGATLSGVGIVIEKTFQKGRKLLDEKHVRVESLARINAFENGQVIFAPED
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_BRASB
Sequence: MARIAGVNIPTNKRVLIALQYIHGIGPKIASEIIEKVKIAEDRRVNQLSDQEVLQIREIIDRDYVVEGDLRRETGINIKRLMDLGCYRGLRHRRGLPVRGQRTHTNARTRKGPAKAIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: COX7C_PIG
Sequence: MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWRLLAMMTLYFGSGFAAPFFIVRHQLLKK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 7C, mitochondrial, Cytochrome c oxidase polypeptide VIIc.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIc family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: DPHB_PYRIL
Sequence: MFYIVGIGPGPGYITERAIQILQEVECIFYEDYTGPLDVATLRRYARVEPVKLARRDLEDESGRKIFECLQEGKKAALVTAGDPMLATSHAALITLAKAKGYSVEVVPGVSIICAAFSASCLSIYKLGGVATVTYPRGGVYSVRPYELVEQNLARGLHTLLLLDIRDDGVFMSPRDAAEVLLTLEGRERRGVFTRDRRVVVVSKLGWGGSVLYAPLGEIVQSEMEGPAVFIVPAGLNPVERECIKTFSK
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: MOAE_STAAR
Sequence: MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
What is the function of this protein?
Converts molybdopterin precursor Z into molybdopterin.  This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group.  The sulfur is provided by MoaD (By similarity).
What are the official names of this protein?
Molybdopterin synthase catalytic subunit, MPT synthase subunit 2, Molybdenum cofactor biosynthesis protein E, Molybdopterin-converting factor large subunit, Molybdopterin-converting factor subunit 2.
What is the protein family that this protein belongs to?
Belongs to the MoaE family.
Protein: RL14_SHEPA
Sequence: MIQMQSTLEVACNSGARRVQCIKVLGGSHRRYAGIGDVIKVSVKEAIPRGKAKKGDVYNAVVVRTKKGVRRPDGSVIRFDRNAAVLLNANLAPIGTRIFGPVTRELRTEQFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: CD8B_HUMAN
Sequence: MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK
What is the function of this protein?
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.  In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex.  The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins.  Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs).  In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.  A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched.  Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs).  Additionally, plays a critical role in thymic selection of CD8+ T-cells.
What are the official names of this protein?
T-cell surface glycoprotein CD8 beta chain.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=Requires the partner CD8A for efficient cell surface expression (PubMed:3145196). The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single- pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Secreted. SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single- pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane; Single- pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 6]: Secreted. SUBCELLULAR LOCATION: [Isoform 7]: Secreted. SUBCELLULAR LOCATION: [Isoform 8]: Secreted.
Protein: MURG_LIMRJ
Sequence: MRLLVSGGGTGGHIYPALALIERLKQVEPDTEVLYVGTTRGLENKIVPDAGIELETMHMQGFKRSLSLENFKTIYLFLNSVHHAKKIISEFKPDVVLGTGGYVSGAVLYAAAKKHIPTVIHEQNSVVGVTNKFLSRYVDQIAIAFEAARSQFPADKVTMAGNPRAQQVAAKKDSDFSWTRYDLKDDVPTLMIFGGSQGAPKINKTVVDAIPEFNKRPYQVIFATGQKRYDDVKKQLAEGNIKPADNVKVVPYIKDMPAKMPRVAALVSRAGATTIAEVTALGVPTILIPSPYVTANHQVKNAQALVKNNAGLMITEDKLDARALLTQADKIMEDEEVRKEMAHAAEKMGRPDAADRLIKILHKAIDEHEK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: IF11_ACIAC
Sequence: MSKEDLIEMQGKVEEVLPDSRFRVTLDNGHQLIAYAGGKMRKHRIRVLAGDRVSLELSPYDLNKGRLTFRHIEGRGPRAPQRGAR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1 1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAP8_ARATH
Sequence: MTGEPSLCIRGCGFFSTSQTKNLCSKCYNDFLKDESARYLATFNVNTKAAEEVTAQEATVLGSKGGCACKKKVGLLGFHCRCGHLFFASHRYPEEHSCPSDYKSAAIDVLAKQNPVVKGDKLFRL
What is the function of this protein?
May be involved in environmental stress response.
What are the official names of this protein?
Putative zinc finger A20 and AN1 domain-containing stress-associated protein 8, AtSAP8.
Protein: DXS_CALS4
Sequence: MLEQINSPYDLKKLDIKDLPRLSEEIRQFIVEKVSKTGGHLASNLGIVELTLALHYVFNSPVDKIIWDVGHQCYVHKMITGRRDKFDTLRQFNGLSGYTKRTESIHDIFGAGHSSTSLSAALGIATARDLKGEKYHVIAVIGDGALTGGMALEALNNIGRSRKDVIVILNHNEMSISENVGSLSLYLSKLRTDPTYNKVKQEIDNLLNIIPPIGKSLHKYIEKIKDSIKQLVVPGMFFEELGFTYLGPIDGHNVEELIEVLERSKKMKGPLLIHVVTKKGKGYMFAEKRPDKFHSAAPFDIETGKFVGEGKDSYSDVFGKTLAEMALKDEKIVAITAAMPEGTGLIHFAKLIPDRFFDVGIAEQHATTFAAGLAVEGYKPYFAVYSTFLQRAYDQVIHDVCIQKLPVVFAVDRAGIVGEDGETHQGVFDISFLRAIPNIAIMSPKDANELVEMVKLSRNLDFPVAIRYPRGKAGEYDISRKPSFPLGKGEVLLEGEKIAVFALGRMVSKSIDAAEILKGHGINPFVVNLRFVKPLDEELILEISNKVDLVVTVEDNVIAGGVGSAILELLNDKKVYRPVLRLGFPDKFIEHGDVESLFKKYGLDSQSIADTILQRYKEMRGS
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: GLUC_CHICH
Sequence: HSQGTFTSDYSKHLDSRYAQEFVQWLMNT
What is the function of this protein?
Glucagon plays a key role in glucose metabolism and homeostasis.  Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
What are the official names of this protein?
Glucagon.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: ORR12_ORYSJ
Sequence: MSSPHVLVVDDTLVDRHVVSMALMRHNVRVTAVESVMQALMFLDSEHDVNMIVSDYCMPDMTGYDLLMEVKKSPKLAHLPVVIASSDNIPERIRKCLDGGAKDYILKPVKIVDLPRILNYI
What is the function of this protein?
Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system.  Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes.  Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
What are the official names of this protein?
Two-component response regulator ORR12, OsRR12, OsRRA11.
What is the protein family that this protein belongs to?
Belongs to the ARR family. Type-A subfamily.
Protein: COX2_BERBO
Sequence: MAYPFQLGLQDATSPIMEELTNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPALTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKHFENWSASMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CLP1_DANRE
Sequence: MTAEAAEKSVEEGLSSSGSAGSSGTRFDLDKETELRFEVEAGERVQLELLSGLAEIFGSELNRNKKYTFGPGSKIAVFTWQGCGVALSGKTEVAYVSKDTPMLLYLNTHAALEQMRRQAEKDNERGPRVMVVGPTDVGKSTVCRMLLNYAVRLGRRPTLVELDVGQSSVSVPGTMSALCIERPADVEEGFSVQAPLVFHFGSTTPGTNIKLYNKLTSSLADAFSQRCEVNRRASVGGCIINTCGWVKGSGYQALVHCASAFQVDVVLVLDQERLYNELKRDLPHFVRVVLLPKSGGVVERSKDCRRETRDEKIREYFYGFRGTSFYPHAFDVRFSDVRIYKIGAPSIPDSCLPLGMSQDDTQLKLVPVSPGRDLTHHVLSVSSVDDEAEVGQSRGILESPACGFIVVTAVDTQAQVMTVLSPAPRPLPRHTLLIMDIRFIDLK
What is the function of this protein?
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids.  dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component.  Plays a role in both tRNA splicing and mRNA 3'-end formation.  Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA.  Its role in tRNA splicing and maturation is required for cerebellar development.  Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation.  Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC).  However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by dicer1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
What are the official names of this protein?
Polyribonucleotide 5'-hydroxyl-kinase Clp1, Polyadenylation factor Clp1, Polynucleotide kinase Clp1, Pre-mRNA cleavage complex II protein Clp1.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEUC_DESAL
Sequence: MGMTIAEKILAAHAGQEEASPGDLINAKVDIALGNDITAPIAIKLFRQSGAAKVFDKDRVVLVPDHFTPTKDINSAMQVKMVRDFAREQELSHWYEGGDSGVEHALLPEKGIVGPGDLVIGADSHTCTYGGLGAFATGVGSTDLAAAMITGEVWLKVPESIKFVYKGKLRPHVEGKDLILHTIGDIGVDGALYMAMEFTGEVIDALPMAERLTMANMAIEAGGKAGIIAPDAKTKEYADGRVIRKPVFYASDPDAKYAKVIEYDVTDLEPQVAFPHLPENTRPISQVGEVPIHQVIIGSCTNGRIEDMRSAARILTGNKADKNVRLIIIPATPQIYRQAMEEGLFDTFLSAGAVISPPTCGPCLGGHMGILAAGERAVATTNRNFVGRMGHVESEVYLANPAVAAASAIAGKIAGPDDI
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: LYRM1_HUMAN
Sequence: MTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEARTLFRKNKNLTDTDLIKQCIDECTARIEIGLHYKIPYPRPIHLPPMGLTPLRGRGLRSQEKLRKLSKPVYLRSHDEVS
What is the function of this protein?
May promote cell proliferation and inhibition of apoptosis of preadipocytes.
What are the official names of this protein?
LYR motif-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: T1R2_MYCPN
Sequence: MSDALDDENVLCFRYKSYYIKDDGSRIDTLNEERIKHIVDFTLDKYLDATQNTPKFDNFENPVKEGFNSIFACESKEAAIEYYKEFKKQIEQKKLPIKIASIIAQTKVVMNKKLV
What is the function of this protein?
The middle section of a putative type I restriction enzyme that if reconstituted might recognize 5'-GAN(7)TAY-3' and cleave a random distance away (Probable).  Subunit R is required for both nuclease and ATPase activities, but not for modification (PubMed:12654995).
What are the official names of this protein?
Putative type I restriction enzyme MpnIIP endonuclease subunit middle part, R protein middle part.
Protein: MDM1_MOUSE
Sequence: MPVRFKGLSEYQRNFLWKKSYLSESYNPSVGQKYSWAGLRSDQLGITKEPGFISKRRVPYHDPQISKYLEWNGTVRKKDTLVPPEPQAFGTPKPQEAEQGEDANQEAVLSLEASRVPKRTRSHSADSRAEGVSDTVEKHQGVTRSHAPVSADVELRPSSKQPLSQSIDPRLDRHLRKKAGLAVVPTNNALRNSEYQRQFVWKTSKESAPVFASNQVFRNKSQIIPQFQGNTFTHETEYKRNFKGLTPVKEPKSREYLKGNSSLEMLTPVKKADEPLDLEVDMASEDSDQSVKKPASWRHQRLGKVNSEYRAKFLSPAQYFYKAGAWTRVKENLSNQVKELREKAESYRKRVQGTHFSRDHLNQIMSDSNCCWDVSSVTSSEGTVSSNIRALDLAGDLTNHRTPQKHPPTKLEERKVASGEQPLKNSTRRLEMPEPAASVRRKLAWDAEESTKEDTQEEPRAEEDGREERGQDKQTCAVELEKPDTQTPKADRLTEGSETSSVSSGKGGRLPTPRLRELGIQRTHHDLTTPAVGGAVLVSPSKVKPPGLEQRRRASSQDGLETLKKDITKKGKPRPMSLLTSPAAGMKTVDPLPLREDCEANVLRFADTLPVSKILDRQPSTPGQLPPCAPPYCHPSSRIQGRLRDPEFQHNMGKPRTNNLQLHPHDAFNDEDADRLSEISARSAVSSLRAFQTLARAQKRKENFWGKP
What is the function of this protein?
Microtubule-binding protein that negatively regulates centriole duplication.  Binds to and stabilizes microtubules.
What are the official names of this protein?
Nuclear protein MDM1, Mdm4 transformed 3T3 cell double minute 1 protein, Mouse double minute 1.
What is the protein family that this protein belongs to?
Belongs to the MDM1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the centriole lumen.
Protein: Y1191_SHESA
Sequence: MSAVIMQQGDLLLNLYIQPKASRDQIVGLHGDELKVAITAPPIDGKANAHLSKYLAKAFKVPKSDVHILKGELGRHKQVRISPPKNVPAEIATLLE
What are the official names of this protein?
UPF0235 protein Shewana3_1191.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: CAPSD_HPBDB
Sequence: MDINASRALANVYDLPDDFFPKIDDLVRDAKDALEPYWKSDSIKKHVLIATHFVDLIEDFWQTTQGMHEIAESLRAVIPPTTAPVPTGYLIQHEEAEEIPLGDLFKHQEERIVSFQPDYPITARIHAHLKAYAKINEESLDRARRLLWWHYNCLLWGEANVTNYISRLRTWLSTPEKYRGRDAPTIEAITRPIQVAQGGRKTSSGTRKPRGLEPRRRKVKTTVVYGRRRSKSRDRRAPSPQRAGSPLPRSSSSHHRSPSPRK
What is the function of this protein?
Self assembles to form an icosahedral capsid.  Most capsid appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins.  Entering capsid are transported along microtubules to the nucleus.  Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta.  Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153.  Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm.  Immature capsids get stucked in the basket.  Capsids encapsulate the pre-genomic RNA and the P protein.  Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm.  The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions (By similarity).
What are the official names of this protein?
Capsid protein, Core antigen, Core protein, HBcAg.
What is the protein family that this protein belongs to?
Belongs to the avihepadnavirus core antigen family.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm.