PharMolix/UniProtQA huggingface dataset:
Protein: NHP2_CAEEL
Sequence: MGKRNLDETMNESTVSEANGDATAPTTEKDEYQALCELVNPIAQPLANRKLAKKVYKLIKKASAGDKTLREGIKDVQKELRRNEKGICILAGNVSPIDVYSHIPGICEEKEIPYVYIPSREQLGLAVGHRRPSILIFVKPSGDFKELYDEVAEALRHLTVEAA
What is the function of this protein?
Required for ribosome biogenesis.  Part of a complex which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
What are the official names of this protein?
Putative H/ACA ribonucleoprotein complex subunit 2-like protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SODL_CWPXG
Sequence: MAVCIIDHDNIRGVIYFEPVHGKDKVLGSVIGLKSGTYSLIIHRYGDISRGCDSIGSPEIFIGNIFVNRYGVAYVYLDTDVNISTIIGKALSISKNDQRLACGVIGISYINEKIIHFLTINENGV
What is the function of this protein?
Virion protein with no enzymatic activity.
What are the official names of this protein?
Cu-Zn superoxide dismutase-like protein.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: RL331_ALKCK
Sequence: MSGKRVLACDICKSRNYSVTSAKKSDTRLTVKKFCKRCNGHTLHVETR
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: CSTF3_MOUSE
Sequence: MSGDAAAEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDARTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFREEYEGKETALLVDRYKFMDLYPCSASELKALGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIITGGAPELAVEGNGPVESSAVLTKAVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKRIR
What is the function of this protein?
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
What are the official names of this protein?
Cleavage stimulation factor subunit 3, CF-1 77 kDa subunit, Cleavage stimulation factor 77 kDa subunit, CSTF 77 kDa subunit, CstF-77.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIAF_BACSU
Sequence: MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKKYSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQVNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMIPEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDFSESKRRVKVSVSLFIGDVDVKYV
What are the official names of this protein?
Protein LiaF.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL20_STRP3
Sequence: MARVKGGVVSRKRRKRILKLAKGYYGAKHILFRTAKEQVMNSYYYAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVADAAAFTALADAAKAKLGK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: GLGS_ECO57
Sequence: MDHSLNSLNNFDFLARSFARMHAEGRPVDILAVTGNMDEEHRTWFCARYAWYCQQMMQTRELELEH
What is the function of this protein?
Major determinant of cell surface composition.  Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.
What are the official names of this protein?
Surface composition regulator.
What is the protein family that this protein belongs to?
Belongs to the GlgS family.
Protein: ATPB_STAAW
Sequence: MGIGRVTQVMGPVIDVRFEHNEVPKINNALVIDVPKEEGTIQLTLEVALQLGDDVVRTIAMDSTDGVQRGMDVKDTGKEISVPVGDETLGRVFNVLGETIDLKEEISDSVRRDPIHRQAPAFDELSTEVQILETGIKVVDLLAPYIKGGKIGLFGGAGVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLYFEMSDSGVIKKTAMVFGQMNEPPGARMRVALSGLTMAEYFRDEQGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTTKGSVTSIQAVFVPADDYTDPAPATAFAHLDATTNLERKLTEMGIYPAVDPLASTSRALEPSIVGQEHYEVARDVQSTLQKYRELQDIIAILGMDELSDEDKQTVERARRIQFFLSQNFHVAEQFTGQKGSYVPVKTTVANFKDILDGKYDHIPEDAFRLVGSMDDVIAKAKDMGVEV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MDH_MORS5
Sequence: MKVAVLGAAGGIGQALALLLKTQLPAGSDLSLYDIAPVTPGVAVDLSHIPTDVTIAGFAGMDPTDALVGADVVLISAGVARKPGMDRSDLFNINAGIIKNLAGKCAEVCPNACIGIITNPVNTTVPIAAEVLKQAGVYDKRKLFGITTLDVIRSETFVSALKGISLADVEVPVIGGHSGVTILPLLSQVKGVEFTAEEVVALTARIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEKGIVECTYVDGGSEHATFFAQPVLLGKNGVEEVLAYGELSEFETNARDAMLEELKANITLGEEFVAG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: AROA_ALKCK
Sequence: MDETIKLLNKAESGLSGTIVVPGDKSISHRAVMFGAMANGTTNVSGFLPGDDCLSTIACFRQMGVAIEQEGDKVTVEGKGLDGLKEPNGVLDVGNSGTTIRLLLGVLSGRPFHSVVVGDDSIGKRPMARVTAPLRQMGAQIDGRETGNKTPLSIRGGQTKAIEYTMPVASAQVKSALLLAGLQAEGETSVTEPQTTRDHTERMLHAFGVKVTTAGKTISIQGGQSLQAADVVVPGDISSAAFFLVAGCIVPGSRVHLKNVGLNPTRAGILEVLKRSGAKLSIDEQVTTGGEPRGDMTISTSELSPFVIEGEEVPTLIDEIPVLAVLATQISGTTIIRDAEELKVKETNRIDTVVGELAKLGADIEATDDGMIIRGGKPLTGGKVDSHGDHRIGMALVIASLCANGPVELANIGAISVSYPQFFEHLQSLQ
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGGD_ECOLX
Sequence: MKIRRIVSTIAIALSVFTFAHAQSFENVENNAKVFSLHLGATRMIYKPNSSGETLAVINEHNYPILVQANVLSEDQKNIAPFIITPPLFRLDALQSSRLRIVKTEGAFPIDRESLQWICVKAIPPKYEDKWAKEEVSGKKSDKATMNIQVSVSSCIKLFVRPADVKGQPDDVAGKIKWQKVGNKLKGVNPTPFYMDIAELRVGEKEITETHYIAPFSSYEYPMPVNGGGDVRWKVVTDYGGISKTFETGLNI
What is the function of this protein?
Involved in the biogenesis of the AAF/I fimbriae.
What are the official names of this protein?
Chaperone protein AggD.
What is the protein family that this protein belongs to?
Belongs to the periplasmic pilus chaperone family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TOIP1_HUMAN
Sequence: MAGDGRRAEAVREGWGVYVTPRAPIREGRGRLAPQNGGSSDAPAYRTPPSRQGRREVRFSDEPPEVYGDFEPLVAKERSPVGKRTRLEEFRSDSAKEEVRESAYYLRSRQRRQPRPQETEEMKTRRTTRLQQQHSEQPPLQPSPVMTRRGLRDSHSSEEDEASSQTDLSQTISKKTVRSIQEAPVSEDLVIRLRRPPLRYPRYEATSVQQKVNFSEEGETEEDDQDSSHSSVTTVKARSRDSDESGDKTTRSSSQYIESFWQSSQSQNFTAHDKQPSVLSSGYQKTPQEWAPQTARIRTRMQNDSILKSELGNQSPSTSSRQVTGQPQNASFVKRNRWWLLPLIAALASGSFWFFSTPEVETTAVQEFQNQMNQLKNKYQGQDEKLWKRSQTFLEKHLNSSHPRSQPAILLLTAARDAEEALRCLSEQIADAYSSFRSVRAIRIDGTDKATQDSDTVKLEVDQELSNGFKNGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLGTSLGLKEVEEKVRDFLKVKFTNSNTPNSYNHMDPDKLNGLWSRISHLVLPVQPENALKRGICL
What is the function of this protein?
Required for nuclear membrane integrity.  Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane.  Binds to A- and B-type lamins.  Possible role in membrane attachment and assembly of the nuclear lamina.
What are the official names of this protein?
Torsin-1A-interacting protein 1, Lamin-associated protein 1B, LAP1B.
What is the protein family that this protein belongs to?
Belongs to the TOR1AIP family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Single-pass membrane protein.
Protein: ARO1_YEAS8
Sequence: MVQLAKVPILGNDIIHVGYNIHDHLVETIIKHCPSSTYVICNDTNLSKVPYYQQLVLEFKASLPEGSRLLTYVVKPGETSKSRETKAQLEDYLLVEGCTRDTVMVAIGGGVIGDMIGFVASTFMRGVRVVQVPTSLLAMVDSSIGGKTAIDTPLGKNFIGAFWQPKFVLVDIKWLETLAKREFINGMAEVIKTACIWNADEFTRLESNASLFLNVVNGAKNVKVTNQLTNEIDEISNTDIEAMLDHTYKLVLESIKVKAEVVSSDERESSLRNLLNFGHSIGHAYEAILTPQALHGECVSIGMVKEAELSRYFGILSPTQVARLSKILVAYGLPVSPDEKWFKELTLHKKTPLDILLKKMSIDKKNEGSKKKVVILESIGKCYGDSAQFVSDEDLRFILTDETLVYPFKDIPADQQKVVIPPGSKSISNRALILAALGEGQCKIKNLLHSDDTKHMLTAVHELKGATISWEDNGETVVVEGHGGSTLSACADPLYLGNAGTASRFLTSLAALVNSTPSQKYIVLTGNARMQQRPIAPLVDSLRANGTKIEYLNNEGSLPIKVYTDSVFKGGRIELAATVSSQYVSSILMCAPYAEEPVTLALVGGKPISKLYVDMTIKMMEKFGINVETSTTEPYTYYIPKGHYINPSEYVIESDASSATYPLAFAAMTGTTVTVPNIGFESLQGDARFARDVLKPMGCKITQTATSTTVSGPPVGTLKPLKHVDMEPMTDAFLTACVVAAISHDSDPNSANTTTIEGIANQRVKECNRILAMATELAKFGVKTTELPDGIQVHGLNSIKDLKVPSDSSGPVGVCTYDDHRVAMSFSLLAGMVNSQNERDEVANPVRILERHCTGKTWPGWWDVLHSELGAKLDGAEPLECTSKKNSKKSVVIIGMRAAGKTTISKWCASALGYKLVDLDELFEQQHNNQSVKQFVVENGWEKFREEETRIFKEVIQNYGDDGYVFSTGGGIVESAESRKALKDFASSGGYVLHLHRDIEETIVFLQSDPSRPAYVEEIREVWNRREGWYKECSNFSFFAPHCSAEAEFQALRRSFSKHIATITGVREIEIPSGRSAFVCLTFDDLTEQTENLTPICYGCEAVEVRVDHLANYSADFVSKQLSILRKATDSIPIIFTVRTMKQGGNFPDEEFKTLRELYDIALKNGVEFLDLELTLPTDIQYEVINKRGNTKIIGSHHDFQGLYSWDDAEWENRFNQALTLDVDVVKFVGTAVNFEDNLRLEHFRDTHKNKPLIAVNMTSKGSISRVLNNVLTPVTSDLLPNSAAPGQLTVAQINKMYTSMGGIEPKELFVVGKPIGHSRSPILHNTGYEILGLPHKFDKFETESAQLVKEKLLDGNKNFGGAAVTIPLKLDIMQYMDELTDAAKVIGAVNTVIPLGNKKFKGDNTDWLGIRNALINNGVPEYVGHTAGLVIGAGGTSRAALYALHSLGCKKIFIINRTTSKLKPLIESLPSEFNIIGIESTKSIEEIKEHVGVAVSCVPADKPLDDELLSKLERFLVKGAHAAFVPTLLEAAYKPSVTPVMTISQDKYQWHVVPGSQMLVHQGVAQFEKWTGFKGPFKAIFDAVTKE
What is the function of this protein?
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
What are the official names of this protein?
Pentafunctional AROM polypeptide.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the shikimate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSQ_MYCTU
Sequence: MTEHNEDPQIERVADDAADEEAVTEPLATESKDEPAEHPEFEGPRRRARRERAERRAAQARATAIEQARRAAKRRARGQIVSEQNPAKPAARGVVRGLKALLATVVLAVVGIGLGLALYFTPAMSAREIVIIGIGAVSREEVLDAARVRPATPLLQIDTQQVADRVATIRRVASARVQRQYPSALRITIVERVPVVVKDFSDGPHLFDRDGVDFATDPPPPALPYFDVDNPGPSDPTTKAALQVLTALHPEVASQVGRIAAPSVASITLTLADGRVVIWGTTDRCEEKAEKLAALLTQPGRTYDVSSPDLPTVK
What is the function of this protein?
Essential cell division protein.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: RS9_CLOB8
Sequence: MAKVQYMGTGRRKKSVARVRLVPGSGKVLVNKREIENFFGLETLRVIVNQPLVLTGTKDRFDVLVNVHGGGFTGQAGAIRHGIARALVKSDEALKPELKKAGFLTRDPRMKERKKYGLKAARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: MASZ_AGRFC
Sequence: MPSEYKEAHVSRTDKFGLSIDDRLYAFLTDEVLPGTGLDSETFFEGFSAIVHELSPKNRELLAKRDALQEKIDGWYRENGAPSDFDAYEAFLKEIGYLLPEGPGFKVETNNVDPEIAVVAGPQLVVPVMNARYALNAANARWGSLYDALYGTDAISDADGAEKGRGYNPKRGDKVIAWARNFLDESAPLETGSWSDVTGFNIADGLLQLAIGAATTGLKDAVQFKGFSGEAAKPATILLGKNGLHTEIVIDPSTEIGKSDRAGISDVILESALTTIMDCEDSVAAVDAEDKVLVYGNWLGLMRGDLTEAVSKGGNTFTRRLNPDRYYTAPDGSALTLPGRSLMLVRNVGHLMTNPAILDRDGRDVPEGIMDAVVTALIALYDVGPSGRRQNSRAGSMYVVKPKMHGPEEVAFANEIFARVENLVGMAPNTMKMGIMDEERRTTVNLKESIRAAKDRVVFINTGFLDRTGDEIHTSMEAGPMIRKGDMKQAAWIAAYENWNVDIGLECGLSGHAQIGKGMWAMPDLMAAMLEQKIAHPKAGANTAWVPSPTAATLHATHYHKVDVAAVQEGLKSRGRAKLSDILSVPVAPRPNWTPEEIQRELDNNAQGILGYVVRWVDQGVGCSKVPDINNIGLMEDRATLRISAQHMANWLRHGVVTEAQIIKTMKRMAAVVDTQNAGDPAYLPMASDFDGSVAFQAAVELVLKGREQPNGYTEPVLHRRRLELKAKQAG
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CETZ1_HALVD
Sequence: MKLAMIGFGQAGGKVVDKFVEYDRERNAGIVRAAVAVNSAKADLLGLKNIPKDQRVLIGQSRVKGHGVGADNELGAEIAEEDIDEVQGAIDSIPVHEVDAFLVVSGLGGGTGSGGAPVLAKHLKRIYTEPVYGLGILPGSDEGGIYTLNAARSFQTFVREVDNLLVFDNDAWRKTGESVQGGYDEINEEIVNRFGVLFGAGEVQDGQEVAESVVDSSEIINTLAGGGVSTVGYASEGVEPRKNNGGGLLSRLTGGDEPDDNLDTAHTTNRITSLVRKAALGRLTLPCEIEGAERALLVLAGPPEHLNRKGIERGRKWIEEQTGSMEVRGGDYPIPGAEKVAGVILLSGVTNVPRIKELQQVAIEAQDNIEEIRQESDSNLETLINDDEDELESLF
What is the function of this protein?
Involved in cell shape control.  Essential for the development of a rod-shaped cell type required for efficient swimming.
What are the official names of this protein?
Tubulin-like protein CetZ1, Cell-structure-related euryarchaeota tubulin/FtsZ homolog 1.
What is the protein family that this protein belongs to?
Belongs to the CetZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=In plates, seen throughout the cytoplasm. Localized as spots, short filaments at or near the envelope. In motile rods, localized at or near one or both poles, as spots, short filaments or end-caps, and at mid-cell.
Protein: MTNA_METJA
Sequence: MTKDLRPIIWDDDKKELILIDQRKLPNKLEYFICKTYEDVAYAIKDMVVRGAPAIGVSAAYGLALAEINGDDIYKAYEVLKNTRPTAVNLFWALDRCLTAYKEGKSILDEAKKIHEEDIETCKKIGMIGEKLIEDGDTILTHCNAGALATSAYGTALSVIRFAFYNGKKIRVIADETRPRLQGAKLTAFELNYEGIPVKVITDNTAGFLMQKGEIDKIIVGADRILADGTVYNKIGTYSLAVLAKYHRIPFYVAAPLSTFDLRSSEEDVIIEERDEKEVAYIDGVRIVPEGVGCYNYAFDKTPPDLITAIITEKGIVKPNRDEILKLFR
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Putative methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, MTNA-like protein, aMTNA, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: OMA1_BOVIN
Sequence: MSFIYGLQSAARNCFFFRFNLLTNWRKCNTQAVTSRDFHQVKINHIVNKSLGLGVNHGDRWTPLPENFLFYRTFNTKRKGCLLSSRSKEIWMISRKCTAWTDSFSRQLPMKNVPVVPAHSMSHPLNCLPTRDIRSFHTSPRCQAAPAPLLLMILKPAQKLLAIIVGRGIRKWWQALPPNKKELFKESLRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPVTGRSKLLILGKEHFRLLSELEYEAWMEEFKNDMLTEKDARYVAVKAVVHHLIECNQDIPGISEINWIIHVVDSPDINAFVLPNGQVFVFTGLLNSVTDIHQLSFLLGHEIAHAVLEHAAEKASLVHLLDFLGLIFLTTIWAICPRDSLALLGQWIQSKLQEFLFDRPYSRTLEAEADRIGLQLAAKACVDVRASSVFWQQMEFAESLHGHPKLPEWLSTHPSHGNRAEHLDRLIPQALKIRETCNCPPLSGPDPRLLFKLSMKNFLEAEKEDLNITVKQKMDALPIQNQKQIPLTCIVDKRTGS
What is the function of this protein?
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria.  Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1.  Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion (By similarity).  Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae.  In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome.  May also cleave UQCC3 in response to mitochondrial depolarization.  Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (By similarity).  Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.  Binds cardiolipin, possibly regulating its protein turnover.  Required for the stability of the respiratory supercomplexes (By similarity).
What are the official names of this protein?
Metalloendopeptidase OMA1, mitochondrial, Overlapping with the m-AAA protease 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: SYD_ENT38
Sequence: MRTEYCGQLRQSHVGQQVTLCGWVNRRRDLGSLIFIDLRDREGIVQVFFDPDRAEALKLASELRNEFCIQVTGTVRARDEKNINADMATGEIEVLASDLTIINRSESLPLDSNHVNTEEARLKFRYLDLRRPEMAQRLKTRAKITSLVRRFMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQVRELMEALVRSLWLDVKGVDLGDFPIMTFAEAERRYGSDKPDLRNPMELVDVADLLKAVEFAVFSGPANDAKGRVAALRVPGGASLSRKQIDDYGNFVKIYGAKGLAYIKVTERAKGIEGITSPVAKFLNAEIVESILERTGAQDGDMIFFGADNKKVVADALGALRLKLGKDLSLTDEAKWAPLWVIDFPMFEDDGEGGLTAMHHPFTSAKDMNADELKAAPETAIANAYDMVINGYEVGGGSVRIHSGEMQQTVFGILGINEQEQREKFGFLLDALKYGTPPHAGLAFGLDRLTMLLTGTDNIRDVIAFPKTTAAACLMTEAPSFANPASLAELGIDVVKKEEKN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_BACCZ
Sequence: MNKEERAKRQSKIRNFSIIAHIDHGKSTLADRILEKTNALTQREMKAQLLDSMDLERERGITIKLNAVQLNYKAKDGEEYILHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNNLEILPVINKIDLPSADPERVRQEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDSEEPLQCMIFDSLYDPYRGVIAYIRVVNGTVKVGDKVRMMATGKEFEVTEVGVFTPKTTQRDELTVGDVGFLAASIKNVGDTRVGDTITHAKRPAAEPLAGYRKLNPMVFCGLYPIDSARYNDLRDALEKLELNDSALEFEPETSQALGFGFRCGFLGLLHMEIIQERIEREFKIDLITTAPSVIYKVFLTNGEDMIVDNPSNMPDPQIIDRVEEPFVKAAIMVPNDYVGAVMEICQGKRGTFIDMQYLDETRVTLTYEIPLSEIVYDFFDQLKSNTKGYASFDYELIGYKPSKLVKMDILLNSEQVDALSFIVHRDSAYDRGKVIVEKLKELIPRQQFEVPIQATIGNKVVARSTIKAMRKNVLAKCYGGDISRKRKLLDKQKEGKKRMKSVGSVEVPQEAFMAVLKMDDN
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TILS_FRATN
Sequence: MSISKSLVLNEIKKFSPSHIIIGYSGGVDSSVLLNISKELDIPLIAIYINHNLHRDSLKWQIHCQQTCQRYNLQFISHSLDKVPKGESFEAWASKQRMAFFQKIMQPYSKPLLLLGHHQDDQAETFLIQAIRGSGLAGLAGIPHYKELHHGGVLRPLLKYSKIEIEEFAKLNNISYIYDDSNEDIKYRRNLIRNQIIPILQQVNPNIGQTLSRSANICAESNNILQKLLTERLQSISQDTNLIISELIKLDDDIQKSLLHLWFKQNTQQSLKSKQIKELHLAINNPSTGWQIDISNYYQIHIQYNQLIIKYPTTINDMSKEDIISWLSKNLNEEIDLTKIVIRDRKPDDKCKYRGRNKPNKLKILFQELQIPTTERSKAKIILKDQQIIAVYPFFICG
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_CLOTE
Sequence: MDFESVIGLEVHAELSTKTKIYCGCTTEFGGKPNTHVCPVCLGLPGSLPQLNKKVVDYAIKAGLALNCEINKSSRLDRKNYFYPDCPKNYQITQDELPICKNGYIEIELENGEKKRVGIERIHIEEDAGKLLHTKAGTLVDFNRAGVPLIEIVSRPDMSSPEEASQYLQKLRSILASIEVSDCKMEEGSLRCDANISVKPKGDTKLGVRAEIKNMNSFKSLEKAVAYETKRHIELIQKGEKLQQETRRWDEANNITIAMRSKEAANDYRYFPEGDSVAITINDKYIDEIRATIPELPHEKAERFVEEFKIPKYDASVLTLTMEMANFFEETAKLSGDAKASSNWLMGDISRLLNEQNMAVEELKFNPTQLSELIKLISSGTISNNIGKKVVEEMFNTGKSPKVIVEEKGLVQNNDEGAILEVVKRIIDENPQSIEDYRNGKNRVLGFLVGLVMKETRGKANPQIVNKLINEEVNKLA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: XTH14_ARATH
Sequence: MACFATKQPLLLSLLLAIGFFVVAASAGNFYESFDITWGNGRANIFENGQLLTCTLDKVSGSGFQSKKEYLFGKIDMKLKLVAGNSAGTVTAYYLSSKGTAWDEIDFEFLGNRTGHPYTIHTNVFTGGKGDREMQFRLWFDPTADFHTYTVHWNPVNIIFLVDGIPIRVFKNNEKNGVAYPKNQPMRIYSSLWEADDWATEGGRVKIDWSNAPFKASYRNFNDQSSCSRTSSSKWVTCEPNSNSWMWTTLNPAQYGKMMWVQRDFMIYNYCTDFKRFPQGLPKECKL
What is the function of this protein?
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET).  Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.  Has some preference for non-fucosylated xyloglucan polymer.  No apparent XEH activity in vitro.
What are the official names of this protein?
Xyloglucan endotransglucosylase/hydrolase protein 14, At-XTH14, XTH-14.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family. XTH group 2 subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted, extracellular space, apoplast.
Protein: PGK_STRP3
Sequence: MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVVFPGVTRGSKLEEAINALEDGQVLLVENTRFEDVDGKKESKNDEELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKDLLEKSNGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.