PharMolix/UniProtQA huggingface dataset:
Protein: RL25_BORHD
Sequence: MDSSRILRYEGRLDFGSLRARRIRAESEIPAVVYGKESDVLHIKIKSSEFNNKFAKFTDNTVLILSDGKIEKCVFIKDVSENLTKRLIYHVDFYEVDKTKDIERDIAIKFVGASVGVKEGGTLSVLRTKIKVKSLPLNLPEFVEVDLTPVKKGDQVTFKDIVLPDNVKLSEENENSVVLLVK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: RNPA_STRZT
Sequence: MKKNFRVKREKDFKAIFKEGTSFANRKFVVYQLENQKNHFRVGLSVSKKLGNAVTRNQIKRRIRHIIQNAKGSLVEDVDFVVIARKGVETLGYAEMEKNLLHVLKLSKIYREGNGSEKETKVD
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: IF_MOUSE
Sequence: MAWLTLYLLSVLWAVAGTSTRAQSSCSVPPDQQPWVDGLQALMENSVTDSDFPNPSILIAMNLAGAYNVEAQKLLTYQLMASDSADLTSGQLALTVMALTSSCRDPGSKVSTLLKKMENWSPSSPGAESSAFYGPGLAILALCQKSSEATLPIAVRFAKTLMMEPSPFNVDTGAVATLALTCMYNKIPVGSQENYRDLFGQALKAIVEKISLRIKADGIIGDIYSTGLAMQALSVTPEQPTKKWDCEKTMHTILNEIKQGKFQNPMSIAQILPSLKGKTYLDVPQVTCGPDHEVPPTLTDYPTPVPTSVSNITVIYTINNQLRGVDLLFNVTIEVSVKSGSVLLAVLEEAQRKNSMFKFETTMTSWGLIVSSINNIAENVNHKTYWEFLSGKTPLDEGVAYYIPFNHEHITANFTQY
What is the function of this protein?
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum.  After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity).
What are the official names of this protein?
Cobalamin binding intrinsic factor, Gastric intrinsic factor, Intrinsic factor, IF, INF.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic cobalamin transport proteins family.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPE2_ALTMD
Sequence: MLNDSVIDIAKQLINRRSVTPEDAGCQEAMCEFLGALGFDNETMVFEDTTNLWSRRGKEGPVFCFAGHTDVVPSGPEDAWKTPPFTATEVNGYLHGRGAADMKGSLAAMLVATREFVNQYPQHKGSIAYLITSDEEGPFINGTTRVIDTLEARNEKIDWCIVGEPSSTDEVGDIVKNGRRGSLTGDLVVKGVQGHVAYPHLAKNPVHSAMAALDELAKSHWDNGNDFFPPTSFQISNIHAGTGAGNVIPGELHVCFNFRFSTEVTDQILIERVTTILDAHELDYDIKWTFNGQPFLTDTGALLDATQGAIEAVKGTPTVLSTAGGTSDGRFIAPTGAQVIELGPVNATIHKIDECVKMADLEQLADMYFGILERLLAN
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase 2, SDAP desuccinylase 2, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: I1B4_CONBE
Sequence: MCLSLGQRCGRHSNCCGYLCCFYDKCVVTAIGCGHY
What are the official names of this protein?
Conotoxin Bt11.4.
What is the protein family that this protein belongs to?
Belongs to the conotoxin I1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PANC_POLNS
Sequence: MKIISDIQELRDHLRGQNRASFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDSYPRTMQADIDKLEKEGVYILFAPTERDLYPQPQEYRVDPPQQLGDILEGEFRPGFFKGVCTVVLKLFSCVQPKVAVFGKKDYQQLMIIHQMAKQFALPVEIIPGETIRAEDGLALSSRNGYLSAEERAEAPELIKALKEVRQRVLDSNIRDAKTISEIEKLAVASLAGRGWKLDYIAIRQQSNLAPASNEQLQAGDPLVILTAAKLGKTRLIDNLEI
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG5_SCLS1
Sequence: MQSLIWASAIPLYITHSSSTIPYLINVPRVSYLALLFPRLTSFFGENVSSFSYEGILLKNLPVGLLCDLYQPELPWRIELGDGPLFDIHDTFINSVKEADFMRNGNAKGIMSMSKEHSTQLWNSVQDNDFSTYHKISTILLNPATALKHIPLRIYLPSSSTPSSTPHPGSSGSSKAPSTASPPSPLFTFKTIQTLIQPQTTSREPQTLGGALNSVLPTLFPSKRDAILAEVILHGATVPFKAVLEDLMREASYADGWLNVCVVMLN
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy).  Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production.  Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function.  The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
What are the official names of this protein?
Autophagy protein 5.
What is the protein family that this protein belongs to?
Belongs to the ATG5 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: PYRR_STAAB
Sequence: MSERIIMDDAAIQRTVTRIAHEILEYNKGTDNLILLGIKTRGEYLANRIQDKIHQIEQQRIPTGTIDITYFRDDIEHMSSLTTKDAIDIDTDITDKVVIIIDDVLYTGRTVRASLDAILLNARPIKIGLAVLVDRGHRELPIRADFVGKNIPTSKEETVSVYLEEMDQRNAVIIK
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: PURA1_SORBI
Sequence: MSLSTLSHPAAAAAAATGSGKSHFRTAPAAQSVRFPKARPPVPAAVSAASAAVHADPAEDRVSSLSQVSGVLGSQWGDEGKGKLVDVLAPRFDIVARCQGGANAGHTIYNAEGKKFALHLVPSGILHEGTLCVVGNGAVIHVPGFFGEIDGLESNGVRCDGRILVSDRAHLLFDLHQVVDGLREAELENSFIGTTKRGIGPCYSSKVTRNGLRVCDLRHMDTFGDKLDVLFKDAASRFQGFQYSKSMLKEEVERYKKFADRLEPFIADTVHVLNESIQQKKKILVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGIAPRVIGDLIGVVKAYTSRVGSGPFPTELFGEEGDRLRKAGMEFGTTTGRPRRCGWLDIVALKYCCQINGFSSFNLTKLDVLSGLSEIKVGVSYSRPDGQKLQSFPGDLDTLEQVQVNYEVLPGWQTDISSVRSYNELPQAARLYVERIEELVGVPVHYIGVGPGRDALIYK
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase 1, chloroplastic, AMPSase 1, AdSS 1, IMP--aspartate ligase 1.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CSRA_BORRA
Sequence: MLVLSRKANESIKIDSNIEISILEIKKDSVKIAIKAPENIKILRSEIYDIIKEENKKSILQDKNNIHKIKKLFDYFSK
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTF2_LEPDE
Sequence: QLTFTPNW
What is the function of this protein?
Hypertrehalosaemic factors are neuropeptides that elevate the level of trehalose in the hemolymph (trehalose is the major carbohydrate in the hemolymph of insects).  Involved in the control of amino acid metabolism during flight.
What are the official names of this protein?
Hypertrehalosaemic factor 2, Hypertrehalosaemic factor II, LeD-CC-II.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: BRAD_ANNTR
Sequence: MSSDLVSKGMAQVFTGLGILLGAGRISSETHEEIMALLSADPGSNTGIMTGTNTGSTSIIPTQSKRVDMGDIPAGLPRPGKETPVSIQSHDLLGLGADLSTEAVQPPETFRAQASPSAPSKELKIICPWWLTDGYSCREHDQGKCPFYHDNVAGGVKHPLICHFWADGGRCTKSQKDCRFAHYPAPHRVTAPMPSKKKSKKLRSSVADDASHPDLGKARRHDPRDDEQNDEVWRNQGRARPGQEW
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of the brasilane terpene glycosides brasilane D and E (PubMed:32936132).  The biosynthesis starts with the activity of the terpene cyclase braA that converts farnesyl pyrophosphate into the sesquiterpene alcohol trichobrasilenol (PubMed:32936132).  Subsequently, trichobrasilenol is glycosylated by the O-glycosyltransferase braB putatively using UDP-GlcNAc as sugar donor to yield brasilane A (PubMed:32936132).  The latter then undergoes two rounds of oxidation performed by the cytochrome P450 monooxygenase braC (PubMed:32936132).  In the first round braC hydroxylates C-12 forming brasilane D, which serves as substrate in the second round to establish the epoxide at the bond between C-5 and C-10 and oxidize the alcohol at C-12 to an aldehyde leading to the final product brasilane E (PubMed:32936132).
What are the official names of this protein?
Brasilane terpene glycosides biosynthesis cluster protein D.
Protein: PPAX_BACC3
Sequence: MKINTVLFDLDGTLINTNELIISSFLHTLHTYYPNQYKREDVLPFIGPSLHDTFSKIDESKVEELITSYRQFNHDHHDELVEEYETVYETVQELKKQGYKVGIVTTKARQTVEMGLKLSKLDEFFDVVVTIDDVEHVKPHPEPLQKALQLLDAKPEEALMVGDNHHDIVGGQNAGTKTAAVSWTLKGRAYLEAYKPDFMLDKMSDLLPILSDMNRS
What is the function of this protein?
Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P.  Might play a role in controlling the intracellular pyrophosphate pool.
What are the official names of this protein?
Pyrophosphatase PpaX.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PpaX family.
Protein: RBSU_STAAS
Sequence: MSIVALLIGLGPLIGWGFFPTVASKFGGKPVHQIIGATVGTLIFAIILAVVTSSGFPTGTNLLFALLSGAGWGFGQIITFKAFELVGSSRAMPVTTAFQLLGASLWGVFALGNWPGIGHKIIGFTALVVILIGARMTVWSERKEASNAKNLRRAVVLLLIGEFGYWLYSAAPQATSIDGLTAFLPQAMGMVIVAVIYGFMNMKAENPFRNKITWLQIISGFFFAFGALTYLISAQPNMNGLATGFILSQTSVVLATLTGIYFLKQHKTSKEMVITIIGLVLILVAASVTVFIK
What is the function of this protein?
Could be involved in the uptake of ribose.
What are the official names of this protein?
Putative ribose uptake protein RbsU.
What is the protein family that this protein belongs to?
Belongs to the GRP transporter (TC 2.A.7.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACP_SINFN
Sequence: MSDIAERVKKIVIDHLGVDAEKVSEGASFIDDLGADSLDTVELVMAFEEEFGVEIPDDAADSILTVGDAVKFIEKAQA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2B10_ARATH
Sequence: MAKADKKPAEKKPAEKTPAAEPAAAAEKKPKAGKKLPKEPAGAGDKKKKRSKKNVETYKIYIFKVLKQVHPDIGISSKAMGIMNSFINDIFEKLAGESSKLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.10, HTB2.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: NMDE3_HUMAN
Sequence: MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASERPLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHASLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGAPAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRDSGGLDEISRVARGTQGFPGPCTWRRISSLESEV
What is the function of this protein?
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium.  Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626).  Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable).  Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex.  Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
What are the official names of this protein?
Glutamate receptor ionotropic, NMDA 2C, GluN2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: RNPA_PEDPA
Sequence: MRKSYRIKKELEFQKVFETRNSFANKKFVVYVMDKPEQPHFRVGISVGKKIGNAVMRNYTKRRIRQSILEFKPLLRQDVDFLVIARPQASGLPMNEVKQQLEHVFKLAGLFASKQSEEE
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: PAND_EXISA
Sequence: MIRTFMHAKLHKATVTEANLHYVGSITIDEDLMDAVGIMENEHVHITNNHNGARIETYVIKGERGSGVICLNGAAARHFQVGDVVIIMAYGQMTAEEAKTHRPKVAVLNEQNEVDQLLYEEIAHTIL
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH04_CHICK
Sequence: MAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDDSKRLRAMHMKEYPDYKYRP
What are the official names of this protein?
SRY-related protein CH4.
What are the subcellular locations of this protein?
Nucleus.
Protein: YIDD_KORVE
Sequence: MKAVLVQMLKGYKRWISPLLPVSCRYVPTCSEYAMEAISIHGAVRGSVLALGRLLRCHPFVRGGYDPVPRSHSCCDDKISTTAHDAVR
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: OPGB_SALDC
Sequence: MSELLSVALFLASVLIYAWKAGRNTWWFAATLTVLGLFVILNITLYASDYFTGDGINDAVLYTLTNSLTGAGVGKYILPGIGIALALVAVFGALGWVLRRRRHHPHHVGYSLLALLLALGSVDASPAFRQITELVKSQMRDGDPDFAVYYKEPAKTIPNPKLNLVYIYGESLERTYFDNDAFPNLTPELGALKNEGLDFSHTMQLPGTDYTIAGMVASQCGIPLFAPFEGNASASVSSFFPQNICLGDILKNSGYQNYFVQGANLRFAGKDVFLKSHGFDHLYGAEELKTVVADPSYRNDWGFYDDTVLDEAWKKFEALSRSGQRFSLFTLTVDTHHPDGFISRTCNRKRYDYDGKPNQSFSAVSCSQENIAEFINKIKASPWFKDTVIVVSSDHLAMNNTAWKYLNKQDRNNLFFILRGDKPQQETLAVKRNTMDNGATVLDILGGDNFIGLGRSSLSGQSLSEVFLNVKEKVLAMKPDIIRLWNFPKEIKDFTVDRDKNMIAFSGSHFRLPLLLRVSDKRVEPLPESEYSAPLRFQLADFAPRDNFVWIDRCYKMAQLWAPALALSTDWCVSQGQLGGQQTVQHVDKAQWKGKTAFKETVIDVTRYQGNVDTLKIVDNDIRYKADSFIFNVAGAPEEVKQFSGISRPESWGRWSNAQLGDEVKIEYKAPLPKKFDLVITAKAFGDNANRPIPVRVGNEEQTLVLGHDVSTITLHFNNPTDANTLVIAPPAPVSTNEGNILGHSPRKLGIGMVEIKVVNVES
What is the function of this protein?
Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.
What are the official names of this protein?
Phosphoglycerol transferase I, Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the OpgB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PACR_MOUSE
Sequence: MARTLQLSLTALLLLPMAIAMHSDCIFKKEQAMCLERIQRANDLMGLNESSPGCPGMWDNITCWKPAQIGEMVLVSCPEVFRIFNPDQVWMTETIGDSGFADSNSLEITDMGVVGRNCTEDGWSEPFPHYFDACGFDDYEPESGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSSHCFVSTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWAVLRLYFDDAGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIIILVQKLQSPDMGGNESSIYFSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFTMDFKHRHPSLASSGVNGGTQLSILSKSSSQLRMSSLPADNLAT
What is the function of this protein?
This is a receptor for PACAP-27 and PACAP-38.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine.  May play a role in spermatogenesis and sperm motility.  Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
What are the official names of this protein?
Pituitary adenylate cyclase-activating polypeptide type I receptor, PACAP type I receptor, PACAP-R-1, PACAP-R1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NR13_CHICK
Sequence: MPGSLKEETALLLEDYFQHRAGGAALPPSATAAELRRAAAELERRERPFFRSCAPLARAEPREAAALLRKVAAQLEAEGGLNWGRLLALVVFTGTLAAALAESGCEEGPSRLAAALAAYLAEEQGEWLEEHGGWDGFCRFFGRHGSQPADQNSTLSNAIMAAAGFGIAGLAFLLVVR
What is the function of this protein?
Shows anti-apoptotic properties.  Counteract the pro-apoptotic activity of BAX.
What are the official names of this protein?
Anti-apoptotic protein NR13, Apoptosis regulator Nr-13.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YL536_MIMIV
Sequence: MYGIYIHDELTINDTELSMDKLCSGIVENQSKCIAVSINSSNIISDLNMSVRKIIYKFGTNRYLFYYYNSKWYTDIHHILSLMDLSLGSFISELQKYYPECDLTMWILRGDGMCIHRKLIDLETMTKIILSFNSNFTRCFKAECIYHMAIVYILIMYQIYILSLIRINT
What are the official names of this protein?
Uncharacterized protein L536.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PMIP_LACBS
Sequence: MFANSARNALKKRPQNLQPFRFQGCLFSKRANRPLTTKVQHLIYASVDDKALVTLFDQPRSTLRSPFATTGLFGHPSLTHPRALISLADATVVRAQLLTDRILRARESRTELLRVVKNLDRLSDMLCGVIDLAELVRNAHPDRSWVDAANRAYETLCEFMNVLNTHVGLYEVLKAVLSDPSIVKTLGPEAHQTALIFWRDFEKSAIDLPAEQRKKFVSLSSDILVLGRQFLEGANAPRPPASIKPSQLSGLKDKGMGVRLQLQAQFTQRDLQVYPGSLQAQMIMRSAPEEEPRRQVYLAANSSTPQQIEVLEKLLRTRAELARLVGRDSFAHMTLDDKMAKTPDNVWNFLDALMDHTKPFARRALHTLSERKQLHHGTSSLPIIQAWDRDFYCPPDPPAPPIPLPPLTLGTVFMGLSRLFQHMYGISLRPADSASGEVWHTDVQKLEVVDQDQGIIGWIYADLFARRGKASGAAHYTVRCSRRTDDDDESSDGTVEGAELLIYESQEFEAVKRHRLPNQDGIYQLPLVVLLCEFARPTPSKGPTVLEWHEVLTLFHEMGHAMHSMIGRTEYQNVAGTRCATDFVEFPSILMEHFLNSPTVLSLFDVDGTSTVRHIGNHHNDPCHFIDTYSQILLAAVDQVYHSPAVLDPTFDSTAELAKVHNTRGLIPYVPGTSFQTQFGHLYGYGATYYSYLLDRAIASRVWRNVFLDDPLDRETGEKFKCEVLRFGGGKDPWKMVSALLDVPELSTGDAEAMREIGRWKINSEIGVHGRH
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.  While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP, Octapeptidyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: KLDC3_BOVIN
Sequence: MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAARGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKTMYIFGGYEQLADCFSNDIHKLDTSTMTWTLICTKGNPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.  The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons.  The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine.  May be involved in meiotic recombination process.
What are the official names of this protein?
Kelch domain-containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm.