PharMolix/UniProtQA huggingface dataset:
Protein: FUS_RINDB
Sequence: MRIPLAALIAMTIPCLATGQIHWGNLSKIGVVGTSSASYKVVTQSSHQSLVIKLMPNITAIDNCTKTEIGEYKRLLGTVLKPIGEALNAITKNIKPIQSSTTSRRHKRFAGVVLAGAALGVATAAQITAGIALHQSMMNSQAIESLKASLVTTNQAIEEIRQAGQEMILAVQGVQDYINNELVPAMGQLSCDMVGQKLGLKLLRYYTEILSLFGPSLRDPVSAEISIQALSYALGGDINKILNRLGYSGSDLLAILESKGIKAKITYVDIESYFIVLSIAYPSLSEIKGVIVHRLEGVSYNIGSQEWYTTVPRYVATQGYLISNFDDTPCAFTPEGTISSQNALYPMSPLLQECFRGSTRSCARTLVSGSIGNRFILSKGNLIANCASILCKCYTTGSIISQDPDKILTYIAADQCPVVEVNGVTIQVGSREYPDAVYLHNIDLGPPISLEKLDVGTDLGNAVTKLERAKDLLDSSDLILKNIKGVSVTNTGYILIGVGLIAVVGIIIVTCCCKKSSSDSRASTVVLNPGLKPDLTGTSKSYIRSL
What is the function of this protein?
Class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.  Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.  This fusion is pH independent and occurs directly at the outer cell membrane.  The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface.  Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes.  Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
What are the official names of this protein?
Fusion glycoprotein F0.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: REX_STAEQ
Sequence: MPDDFKIPRATLKRLPLYYRFVSILKGKGIDRVNSKTISEALQIDSATIRRDFSYFGELGKKGYGYNIDSMLEFFKSELSESDQIKIAIIGIGNLGRALLTYNFSIHDEMTITEAFDIRPDIIGENIGDVVVKHSDDIKTTLESEDIDVVILTTPDNVAQQVADELVKAGVKGILNFTPRRIKTPQDVQVHHIDFGIELQSLLFFMKNYSK
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPT6H_CAEEL
Sequence: MDFIDNQAEESDASSGHSDDEEPQSKKMKMAKEKSKRKKKMVASSDEDEDDDDDEEENRKEMQGFIADDDDEEEDAKSEKSEKSRHSGEDELDDEDLDLINENYDIRETKKQNRVQLGDSSDEDEPIRRPNHEDDDLLSERGSDDGDRRKDRGRGDRGGYGSESERSEDDFIEDDGDAPRRHRKRHRGDENLPEGAEDDARDVFGVEDFNLDEFYDDDDGEDGLEDEEEEIIEDDGEGGEIKIRRKKDTTKKSTLLESIEPSEIDRGFLLPGDKKIAKEDLPERFQLRRTPVTEADDDELESEALWIIKYAFEEGTVTNQADLDQDDKLDCIMNLDPSVYEDRKKAVIKSIKKVLQFIRVRSNSFEPTFIGFYRKEDIDNLLTMNNLWRVYDFDEKWCHLSEKKNKIYDLMRRMREYQELSDDLTAKRRPISDADLMDTKYAETLEQLTDIHANFQLLYGALLDDMIRWEKGRLTGEEEEQEYRVKFKSSIRNDKYQMCVENGIGELAGRFGLTAKQFSENLNWKKHDIEQDPMLPLEAAEEYVCPAFSDSDMVLNGAKFMLAKEISRQPQVRHSVRQEFRQSAHFWIKPTKKGRDTIDQTHPLYDKRYIKSKPVRSLTAEEFLFYHKAKEDGLVDVLIMYESEEDQDSNNYLVNKYLSDSIFQKDEYTENVEQWNSVRDECVNMAITEMLVPYMRDELYNTILEEAKTAVAKKCRKEFASRISRSGYLPDFDNNDDDDDGMDQHGARRIMAVCYPTERDEASFGVMVDENGAIVDYLRMVHFTKRTFGGGNNGLRKAESMDLFKKFVQRRKPHAIGLNIEDMECTRLKRDLEEAVADLFSQNLIYKPIPVFLMDNEAAKVYMRSNVSLAENPDHPPTLRQALSLARLLLDPIPEYAHLWNIDEDIFCLSLHPLQRDIDQEQLALVLSHELVNKVNEEGVDINKCAEFPHYTNMLQFTCGLGPRKATDLLKSIKANDNLIESRSKLVVGCKLGPKVFMNCAGFIKIDTIKVSEKTDAYVEVLDGSRVHPETYEWARKMAVDALEVDDSADPTAALQEIMESPDRLRDLDLDAFADELSRQGFGEKKSTLYDISSELSARYKDLRQPFQEPTGELLYDLLARSGKEIREGAKVLGTVQSVQYRKVDKDAADSMLPDVGEDGLFTCPCCKSFTSSAPGGIQEHMLGDSRQGGCPGTPVGIRVRFDNGMTGFCPNKNISSSHVDNPLTRVKINQPYYFKVLKLDKERFSLFLSCKSSDLKEDDLSQRDQYWDEHQYQADLELMKSESKKKTEANTRVKRVIAHPNFHNVSYEAATKMLDEMDWSECIIRPSANKDSGLSVTWKICDRVYHNFFVKESAKDQVFSIGRQLSVGGEDFEDLDELIARFVQPMIQISHEITTHKYFFPNGTCEETEAVEQFVREKKRELGRSPYVFSASYRQPCQFCISYMFDNTERIRHEYFKIVPHGVRFRHQNFDTLDRMMAWFKRHFHEPPIELRRSAIPAPQYRVGAPPAAPYYPPQFVGYH
What is the function of this protein?
May regulate transcriptional elongation by RNA polymerase II.  Required for several aspects of morphogenesis of C. elegans, including regulation of division in the germline and gut and specification of ventral-uterine precursor cell fate.
What are the official names of this protein?
Suppressor of Ty 6 homolog, Abnormal embryogenesis protein 5.
What is the protein family that this protein belongs to?
Belongs to the SPT6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FUCO_MOUSE
Sequence: MLLLLLLLLVAAAQAVALAPRRFTPDWQSLDSRPLPSWFDEAKFGVFVHWGVFSVPAWGSEWFWWHWQGDRMPAYQRFMTENYPPGFSYADFAPQFTARFFHPDQWAELFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGAAVRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVRAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTSFLAWLYNDSPVKDEVIVNDRWGQNCSCHHGGYYNCQDKYKPQSLPDHKWEMCTSMDRASWGYRKDMTMSTIAKENEIIEELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLQINGEAIYASKPWRVQSEKNKTVVWYTTKNATVYATFLYWPENGIVNLKSPKTTSATKITMLGLEGDLSWTQDPLEGVLISLPQLPPTVLPVEFAWTLKLTKVN
What is the function of this protein?
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
What are the official names of this protein?
Tissue alpha-L-fucosidase, Alpha-L-fucosidase I, Alpha-L-fucoside fucohydrolase 1, Alpha-L-fucosidase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 29 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: CBL_HUMAN
Sequence: MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT
What is the function of this protein?
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors.  Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:17094949).  Ubiquitinates SPRY2 (PubMed:17094949, PubMed:17974561).  Ubiquitinates EGFR (PubMed:17974561).  Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and terminates signaling.  Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation.  Participates in signal transduction in hematopoietic cells.  Plays an important role in the regulation of osteoblast differentiation and apoptosis.  Essential for osteoclastic bone resorption.  The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.  May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.  In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, Proto-oncogene c-Cbl, RING finger protein 55, RING-type E3 ubiquitin transferase CBL, Signal transduction protein CBL.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Cell projection, cilium. Golgi apparatus. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Protein: PUTA_RHIML
Sequence: MSPNPLQKPAIDAAPAPFADFAPPVRPQSTLRRAITAAYRRPETECLPPLVEAATQSKEIRDAAASTARKLIEALRGKHSGSGVEGLVQEYSLSSQEGVALMCLAERPVRIPDTATRDALIRDKIADGNWKSHLGRSRSLFVNAATWGLVVTGKLTSTVNDRTLAARVTRLISRCGEPVIRRGVDMAMRMMGEQFVTGETIEALKRSKELEEKGFSYSYDMLRERPTAADAERYYRDYESAIHATAKPRGRGIYEGPGISIKLSALHPRYRQAARVMGELLPRVKALALLAKNYDIGLNIDAEEADRLELSLDLLEVLCLDGDLSGWNGMGFVVQAYGKRCPFVLDFIIDLARRSGRRIMVRLVKGAYWDAEIKRAQLDGLADFPVFTRKIHTDVSYMPRTQAACRDRCGVPQFATHNAQTLAAIYHMAGKDFHVGKYEFQCLHGMGEPLYEEVVGRGKLDRPCRIYAPVGTHETLLAYLVRRLLENGANSSFVHRINDPKVSIDELIADPVEVVRAMPVVGAKHDRIALPAVLFGDARTNSAGFDLSNEETLASLTEALRESAAMKWTALPQFATGPAAGETRTVLNPGDHRDVVGSVTETRKRTHGAPCACRRRGAGLGGRLAERAACLDRAAELMQARMPTLLGLIIREAGKSALNAIAEVREAIDFLRYYAEQTRRTLGPATPLGPIVCISPWNFPLAIFTGQIAAALVAGNPVLAKPAEETPLIAAEGVRILREAGIPASALQLLPGDGRVGAALVAGRDAGVMFTGSTEVARLIQAQLADRLSPAGRPVPLIAETGGQNAMIVDSSALAGQVVGDVITSAFDSAGQRCSALRVLCLQEDVAGPHPDDAEGRAARHCISAAPIVFSVDVGPVITSEAKDNIEKHIERMRGLGRKVEQIGLASETGVGTFVPPTIIELEKLSDLQREVFGPVLHVIRYRRDDLDRLVDDVNATGYGLTFGLHTRLDETIAHVTSRIKAGNLYINRNIIGAVVGVQPFGGRGLSGTGPKAGGPLYLGRLVTTAPVPPQHSSVHTDPVLLDFAKWLDGKGARAEVEAARNAGSSSALGLDLELPGPVGERNLYTLHARGRILLVPATESGLYHQLAAALATGNSVAIDAASGLQASLKNLPQTVGLRVSWSKDWAADGPFAGALVEGDAERIRAVNKAIAALPGPLLLVQAASSGEIARNPDAYCLNWLVEEVSASINTAAAGGNASLMAIG
What is the function of this protein?
Oxidizes proline to glutamate for use as a carbon and nitrogen source, and also functions as a transcriptional repressor of its own gene.
What are the official names of this protein?
Bifunctional protein PutA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the aldehyde dehydrogenase family.
Protein: ISPG_PROMH
Sequence: MHKESPIIRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKSLERVGVDIVRVSVPTMDAAEAFKLIKQQVKVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRQVVDCARDRNIPIRIGVNGGSLEKDIQEKYGEPTPEALVESAMRHVDILDKLNFDQFKVSVKASDVFLAVDSYRLLAKKIDQPLHLGITEAGGARAGSVKSAIGLGILLSEGIGDTLRISLAADPVEEVKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNELEQRLEDIITPMDVSIIGCVVNGPGEAEVSTLGVTGAKTRSGFYEDGVRQKERLDNSNMIDLLEAKIRTKAAMLDGNLRININQLDK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: HDGF_MOUSE
Sequence: MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCAAEPEVEPEAHEGDGDKKGSAEGSSDEEGKLVIDEPAKEKNEKGTLKRRAGDVLEDSPKRPKESGDHEEEDKEIAALEGERPLPVEVEKNSTPSEPDSGQGPPAEEEEGEEEAAKEEAEAQGVRDHESL
What is the function of this protein?
Acts as a transcriptional repressor (By similarity).  Has mitogenic activity for fibroblasts (By similarity).  Heparin-binding protein (By similarity).
What are the official names of this protein?
Hepatoma-derived growth factor, HDGF.
What is the protein family that this protein belongs to?
Belongs to the HDGF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted, extracellular exosome. Note=Secreted by exosomes and is located inside the exosome (By similarity). May also be secreted as free protein via an as yet unknown pathway (By similarity).
Protein: SAT16_STACB
Sequence: MVELNPVTITNDNATPRGHVLKLILVESRDIIRAVKTRLCPQYTISYLAQAATVIAMLDTYSSKSELSKPDFFVALTVVNGRRYLREDLESNYLAGYVTGAPIKIEKLRSLLVSLDDSKDIIVSALEKAAKDAKRRLDMWIYDQSQLATGFRIHSFKGAMSSENPELFKKTAVPYLSSYGINEV
What is the function of this protein?
Trichothecene 15-O-acetyltransferase; part of the satratoxin SC2 cluster involved in the biosynthesis of satratoxins, trichothecene mycotoxins that are associated with human food poisonings (PubMed:25015739).  Satratoxins are suggested to be made by products of multiple gene clusters (SC1, SC2 and SC3) that encode 21 proteins in all, including polyketide synthases, acetyltransferases, and other enzymes expected to modify the trichothecene skeleton (PubMed:25015739).  SC1 encodes 10 proteins, SAT1 to SAT10 (PubMed:25015739).  The largest are SAT8, which encodes a putative polyketide synthase (PKS) with a conventional non-reducing architecture, and SAT10, a putative protein containing four ankyrin repeats and thus may be involved in protein scaffolding (PubMed:25015739).  The putative short-chain reductase SAT3 may assist the PKS in some capacity (PubMed:25015739).  SAT6 contains a secretory lipase domain and acts probably as a trichothecene esterase (PubMed:25015739).  SAT5 encodes a putative acetyltransferase, and so, with SAT6, may affect endogenous protection from toxicity (PubMed:25015739).  The probable transcription factor SAT9 may regulate the expression of the SC1 cluster (PubMed:25015739).  SC2 encodes proteins SAT11 to SAT16, the largest of which encodes the putative reducing PKS SAT13 (PubMed:25015739).  SAT11 is a cytochrome P450 monooxygenase, while SAT14 and SAT16 are probable acetyltransferases (PubMed:25015739).  The SC2 cluster may be regulated by the transcription factor SAT15 (PubMed:25015739).  SC3 is a small cluster that encodes 5 proteins, SAT17 to SAT21 (PubMed:25015739).  SAT21 is a putative MFS-type transporter which may have a role in exporting secondary metabolites (PubMed:25015739).  The four other proteins putatively encoded in SC3 include the taurine hydroxylase-like protein SAT17, the O-methyltransferase SAT18, the acetyltransferase SAT19, and the Cys6-type zinc finger SAT20, the latter being probably involved in regulation of SC3 expression (PubMed:25015739).
What are the official names of this protein?
Trichothecene 15-O-acetyltransferase SAT16, Satratoxin biosynthesis SC2 cluster protein 16.
What is the protein family that this protein belongs to?
Belongs to the trichothecene O-acetyltransferase family.
Protein: YTDC2_HUMAN
Sequence: MSRPSSVSPRQPAPGGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRKSSADTEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRGTEDRSDQSSLKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQQKGIWSTTPSNERKLNRAFWESSIVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPLVGEQLLQLWERLPLGEKNTTD
What is the function of this protein?
3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596).  Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321).  Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity).  Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321).  Required for both spermatogenesis and oogenesis (By similarity).
What are the official names of this protein?
3'-5' RNA helicase YTHDC2, YTH domain-containing protein 2, hYTHDC2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region.
Protein: THIC_PARXL
Sequence: MNANPKFLSADAHVDEAAVAPLPNSRKVYVTGSRPDIRVPMREISQADTPDSFGGEKNPPVFVYDTSGPYSDPEARIDIRAGLPALRQAWIEERGDTEALTGLSSDFGRERAADTATADLRFQGLHRTPRRAIAGKNVSQMHYARKGIITPEMEYIAIRENQRRAEYLESLKTSGPNGEKLAAMMGRQHPGQAFGASAFGPNGLTEITPEFVREEVARGRAIIPNNINHPESEPMIIGRNFLVKVNANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTAKRMTGIVSRGGSIMAKWCLAHHKESFLYEHFEDICEIMKAYDVAFSLGDGLRPGSIYDANDEAQLGELKTLGELTQIAWKHDVQTMIEGPGHVPMQLIKENMDLQLEWCDEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKTGIITYKLAAHAADLAKGHPGAQVRDNALSKARFEFRWEDQFNLGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSMKITQDVREFAAQQGVTDDEALKKGMEVKSIEFMKKGAEIYQRQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: NDE1_CRYNB
Sequence: MVDDEDDITFDSPEEEIAHYREKYRQALDMLTDTRAELEEFQQSSKELEDEMEQELAANDKQQADLREKIKRLDAEKEEWRTKHIALQKMHSSTTSAMQREMDNLRSERDKTLVALRDLEMGNDELERNERVAISSLLDLESKYNRAIEEKTLLEQDLAQKDELETETQRLKDELREANEEISILKDQLARAIATPPSSVSTSSPIHDAACDLSRIHLSDDINASPLPPPVPSKNKSITPEGHSPRRGLSRSGTMSSIPVASPSTKRFSQQIPHSPSFSTLSRSTTSRNLAAAAGTPGSPALARSRSGIPQASPARGIVLASHQQTKSRGFKLLHDLQARLKATDDKLGGAKVPRRNVSNPASVFGVGKRVTSTTSTTSSTTTAPAPHARVTALAKDHNTTPTAQSQQFPGSGIMSPGWVLVGEGEGEDTPTGPWSMTLPAEPNSPLDPTFRSSSTTSNRSLPSRPGIPSPLASGSARSTTSGTAQRQAGQRPSSRLGLKASRRDSEARPLSPSMIPVPSFSSRPMSPDVYQPLRSATPTSGFSSFSASASTSNPPRPNSRTGKRNPIGRGPPPLSSSTRLHHQRSRQSLSGAGPTPTTGADKVERAKRGPRRSSLSNMDKPSLMSASPGSRTPSGRPTSVHVFRETPPPVPRIPSAILKESKVKK
What is the function of this protein?
Required for nuclear migration.
What are the official names of this protein?
Nuclear distribution protein nudE homolog 1.
What is the protein family that this protein belongs to?
Belongs to the nudE family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Localizes to the plus ends of microtubules.
Protein: YNDA_BACSU
Sequence: MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTYTYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGSIGKFVDGSNNKAEFFVTDYSGKSKTVTFYD
What are the official names of this protein?
Uncharacterized protein YndA.
Protein: TRPD_NEIMF
Sequence: MITPQQAIERLISNNELFYDEMTDLMRQIMRGQVLPEQIAAILTGLRIKVETVSEITAAAAVMREFATKVPLENAEGLVDIVGTGGDGAKTFNISTTSMFVAAAAGAKVAKHGGRSVSSSSGAADVVEQMGANLNLTPEQVAQSIRQTGIGFMFAPNHHSAMRHVAPVRRSLGFRSIFNILGPLTNPAGAPNQLLGVFHTDLCGILSRVLQQLGSKHVLVVCGEGGLDEITLTGKTRVAELKDGKISEYDIRPEDFGIETRRNLDEIKVANTQESLLKMNEVLEGREGAARDIVLLNTAAALYAGNVAASLSDGISAAREAIDSGRAKSKKEEFVGFQPQQRCHFLGKMELG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: DEOB_SHESA
Sequence: MKRTVIMMLDSFGVGAAGDAAKFGDLGSDTFGHIAKACAEGEADIGREGPLTLPNLARLGLAHAAMESTGAFAPGFADNVELIGAYGHAQELSSGKDTPSGHWEMAGVPVLFEWGYFSEHQNSFPKELTDKILARAGLDGFLGNCHASGTTILEELGEEHMRSGKPIFYTSADSVFQIACHEGTFGLENLYRLCEIAREELEPYNIGRVIARPFDGTGPSDFARTGNRKDYSLEPPAKTVLDKLKAAGGEVVSVGKIADIYAYCGITKKVKANGLEALFDATLAEVKSAGENTIVFTNFVDFDSHYGHRRDVAGYAKGLEYFDSRLPEMLALLDEDDLLILTADHGCDPTWQGTDHTREYVPVLAYGAGLKAGSLGRRNSFADIGQSIASYFKLEPMEYGESFI
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBP16_XENLA
Sequence: MVKKRGTNLPAQDFLDAEPVCKHLRKALDDGSVKRALVNVEWTMCQDCQADNKEKNNSEDESAEDPSVWLCLKCGHRGCGRNSVAQHALNHYNTPRSEPHCLVLNVDMWSAWCYLCDNEVPYNRTSRLGQLVDYLQRKAKAKNKNSNSVVSNEEVKTEIVTENEVKKIQYQDEKPDVQAKQEKASSTQKISTEPTVKGLSNLGNTCFFNAVMQNLSQTPALSELLNEVKTFRKPVTVLLPDSSSPKILEVNLEQQPGPLTLAMWQFLTEMHETKKGVVTPKELFSQVCKKAIRFKGYQQQDSQELLRYLLDGMRGEEIQRVTLAMSKSLQSTLDEEEIKKIVKDYEKRRTIPNFVDCLFGGELTSTIMCEECHTVSLVHEPFLDLSLPVLDDLIVKKNSKSTPPARERKEEEEEEENDDDRYVKERDEVSPGASKHLQKKAKKAAKKQAKNQRRQQKWQGKTVLFTDLAKQECSEDEEEVSQTKTNTRPDNETPTADGLNTMETDLSTLENGNEESADGLNTMETDLSTLENGNEEMAGGFKTMEMDLSTLENGSETIKSAVEGITEHTDLDSSVHNNVGSVETNALVGNMENNNNIEVNKTPERTAGSGGDSMEAMAAVENGNADAVNVDDTEAVNGLIDSANMDHELTNSLNRLQLSSDLEPTQVEIEILPDKEQPHTQVYEVVNEDPKTAFSTLSNRKDLPIDEFSVLSCLYQFTHKETLTGNNKLLCNVCTRKQASRLNNSNKGEKKFVYTNAKKQMLVSNPSPILTLHLKRFQQNGFNLRKINRHIKFPEVLDLAPFCTAKCKNVPEGESRLLYSLYGVIEHSGSMRSGHYTAFVKLRHPNQQLCKMLFTGVIPEVSGSEPGQGSWYHISDSHVQAVSLSRVLSSQAYLLFYERML
What is the function of this protein?
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator.  Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis.  Regulates Hox gene expression via histone H2A deubiquitination.  Prefers nucleosomal substrates.  Does not deubiquitinate histone H2B.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 16, Deubiquitinating enzyme 16, Ubiquitin thioesterase 16, Ubiquitin-specific-processing protease 16.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP16 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y4190_RHOPA
Sequence: MATSAAAVQEDPATNFAKDQLRAIIERIERLEEEKKTISDDIRDVYAEAKGNGFDVKALRTIVRMRKQDANERAEQETILETYMQALGML
What are the official names of this protein?
UPF0335 protein RPA4190.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.