PharMolix/UniProtQA huggingface dataset:
Protein: TMM70_CHICK
Sequence: MLLRAAGCWRAAASRPGPVWLRGAEHRGLPLASRRLGLPLPLPLAAGGRRLRSGCGALPEVASFQGVAVRSLSTSAPSDHPEHGRLVYKGNLAKAVLGVRFFSYSTSIFNLFMAPYLMLKTGIGFDSLFLQAAFYGLIGFFTFVTPVTLHILTKGYVIRLYYKEEMDTYTAITYNAILAEKATVFHQKDVKIPDITKMFTTFYAKTKSMLVNPTLFPDPQDYNRLMGYDKAFCFDFEEEEKDGESK
What is the function of this protein?
Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1.  Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis.
What are the official names of this protein?
Transmembrane protein 70, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the TMEM70 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mostly located within the inner cristae membrane.
Protein: Y348_MYCGE
Sequence: MKRLFWNLKHKKAWLVLLLGTGMILSSCSNIDQSFFRELSVESVEKNTAYNQLPVNSTTFRNLVFGTRSYNDGNYVVVIATETDSSQINFLNGSTNQGTSSLSWGGTLGTTIRQVQNRYSTYPNGVKFLIWNDIAPGSVKWNPYARFPVVDRKNELASQEDKDNSNKLRRSDASAVRYREIVDFIQRTYGGNVANLINQSNVHAQTVGNDVTKAIVIAFRKDNLNKIRANFYGLDNSTNPNAPGSGQGDSTPPASSGEGGGSDGSSGGDSSSGNGQNTTPTSPQSSQPAVQRSQKSYGIKQHAVRVSVDFLNFLDSVYTPLN
What are the official names of this protein?
Uncharacterized lipoprotein MG348.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: Y371_CERSK
Sequence: MNISRNEQRALHVLALGGRILHERDDRRKITAVTCVTREGMILSDFALETFLRLRRKRLIESRSGSPYCISKRGRLSVRAQLDNQGA
What are the official names of this protein?
UPF0386 protein RSKD131_0371.
What is the protein family that this protein belongs to?
Belongs to the UPF0386 family.
Protein: DNAJ_XANAC
Sequence: MSKRDYYEVLGVARGASDEELKKAYRRCAMKHHPDRNPGDAAAEAAFKECKEAYEVLSDGNKRRAYDAHGHAAFEHGMGGGGGPGGPDMGDIFGDIFGNIFGGGAAGPRAARRGADVGYVLELDLEEAVAGIERRIEIPTLIECAPCHGSGSEDGKVETCGTCHGRGQVRIQRGIFAMQQSCPHCDGRGTLIQNPCKTCHGAGRVEEDKVLSIKVPAGVDTGDRIRLAGEGEAGPAGTPPGDLYVEVRVREHAIFQRDGDDLHCEVPIRISQAALGDTVRVATLGGEAEIRIPAETQTGKLFRLRGKGVRSVRSRSEGDLYCRVVVETPVNLTADQRELLQQFEATFTGEDARKHSPKSATFIDGVKGFWDRMTS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCSK9_CALJA
Sequence: MGTVSSRRLWWPLPLLLLLLLGPTGTRAQEEDDDDYEELVLALRSEEDGLVDALQHGATATFHRCAKDSWRLPGTYVVVLKEETHRSQPERTARRLQAQAARRGYLIKLLHVFHDLLPGFLVKMSRDLLELALRLPHVDYIEEDSSVFAQSIPWNLERITPARYRADEYQPPNGGSLVEVYLLDTSIQSGHREIEGRVMVTDFGSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASLRSLRVLNCQGKGTVSSTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSRSGTSQAAAHVAGIAAMMLSAKPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAMARCAPDEELLSCSSFSRSGRRRGERIEAQGGRRVCLAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAGAGMGTRAHCHQQGHILTGCSSHWEVEDLGTHKPPVLRPGGQHDQCMGHRGASTHASCCHAPGLECKVKEHGLPAPQEQVTVTCEEGWTLTGCSALPGTSHILGAYAVDDTCVVRSRDVSTTSSTSEETVATVAICCRSQHLAQASQELQ
What is the function of this protein?
Crucial player in the regulation of plasma cholesterol homeostasis.  Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments.  Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway.  May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.  Can induce ubiquitination of LDLR leading to its subsequent degradation.  Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner.  Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.  Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation.  Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 9, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity).
Protein: UFL1_DROPS
Sequence: MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQLLEVVFTNNGKEYITPDHLEREIQDELYANGGRANLVEVSRTLNVDLSRIVALAERIAAENPLVHLVLGQLIDEDYISHIAQEINEKLALRGEISISDLASQFDLPSEFLQQDVVEKHLGKIIKGRQDATNPRVFFTQAYIQRCKAKIRGALAAITRPTNVAVILQQINVQEKIFHSLLDEISPAGQVTSKLANAQYVPHIYAKTQADWVNSFYKQNSFLEYDAINKLGISDAKSYIRKQFPNEEFLFLKRVALGARLVELTVVTALNECSATKQYLDLTTILPSNLSEEDIEEVFSAIMAQKHSNPSNFVYLDSIVFSQPYLTELVQPCHALAEAQAKAAIDSGVYQQFVVEKTLAQKGNASFQDQDDDGKLDKRDERRKKASSGKAGGGAQGRETKTKSTKKHQRRSAAAQNDSDDEDDVQHQGSRGAGGGGGNKKTVKPLDLVKTADIEKLINASLQEEGLEHLAPSIAALYLNQLNQAALAKAQELYEATPQTNRRQTHAAIQDRINTLLIDIRLYEKGLKLFSHDTQTQLVKYLLKSLGNDICNELSLYVASECNLTVKNTSLNVDQRIKLAQECDAEYRSALLEQNKALNKSIDDFELATESVLKACSMIIKKVDKKKDRLLIADHKNKLQQQLLDCQEPALLLHLAALILFTTISGCILHASGKFVSAILQHIRGSLSDQQNDMLLRYHDLVLQVLQTAPESDDSKIAHEQLQIMQSKVVELAQNYTRASVSKAD
What is the function of this protein?
E3 UFM1-protein ligase that mediates ufmylation of target proteins.
What are the official names of this protein?
E3 UFM1-protein ligase 1 homolog, E3 UFM1-protein transferase 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the UFL1 family.
Protein: RL3_CHLTE
Sequence: MGAILGKKIGMTRLYNDKREAVPCTVIQAGPCYVTQVKSTEKDGYEAYQLGFGERDEKKVSKPLAGHYKKAGKNPGYILSEVSKSLIVGELEAGATVPVDVFKEGDKVNVLGVTKGKGFAGVVKRHNFGGGSRTHGQSDRLRAPGSVGGSSDPSRTFKGTRMAGRMGGKNKTVQNLVIVKVMPESNLIVVKGAVPGPKNSYVKIVSTTK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: TKNA_SCYCA
Sequence: KPRPGQFFGLM
What is the function of this protein?
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
What are the official names of this protein?
Substance P.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: OPGH_XANCP
Sequence: MDGTVTLSPAPTDLPPVSSLDAGQPTLPPEAPLAMPEQSLREGSLQVRHQRTSPMGIGLRRFYLIGGTLTATAVAVWVMLSVLWPGGFSVLEGCLLGLFVLLFAWIAMSFASAVAGFITVVARAGRKLGIDPDAPLPSLHTRTALLMPTYNEDPRRLLAGLQAIYESVAETGQLEHFDFFVLSDTTREHIGRAEEQVYAELCDSVGGHGRIFYRRRADNAARKAGNVADWVRRFGGNYPQMLILDADSVMTGDTIVRLVAGMEDNPDVGLIQTLPAVVNGQTLFARMQQFGGRVYGPIIAFGVAWWHGAESNYWGHNAIIRTQAFADHAGLPSLRGRKPFGGHVLSHDFVEAALMRRGGWAMHMVPYLQGSYEEGPPTLTDLLVRDRRWCQGNLQHAKVVGAKGLHWISRMHMMIGIGHYFTAPMWGMLMLVGIGIPLAGAGIDLAQGLPFSPARYWHGSSDGNAIWIFVCTMFVLLAPKLLGYIALLLNPRERRACGGAIRAALSILLETVLAALMAPVVMYLQSRGVFEVLAGKDSGWDAQVRDDGKLSWPALIRSYGGLSVFGLFMGTLAYLVSPSLAAWMAPVIVGMVVSIPVVAVTSLRRTGLALRRAGIFCIPEELDPPKVLVRASELRRAAALEPSLI
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis glucosyltransferase H.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. OpgH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUSG_BORBU
Sequence: MSRAWYVVQTYSQYEKKIEQDIRLLINEGVFGGVVLDVKAPIEKVEEIRNGKKRIRERKIWPGYILIELDLPEVGWKDIIANIIKVQGVINFVGVSKGQRPIPINDEEVKSVFMLTGEIKANKSIFMLYDFEEGERVRIKGGPFDSFEGLISSIDYERKKLKVAVQIFGRSTPVEVDFQHIEKI
What is the function of this protein?
Participates in transcription elongation, termination and antitermination.
What are the official names of this protein?
Transcription termination/antitermination protein NusG.
What is the protein family that this protein belongs to?
Belongs to the NusG family.
Protein: SPB10_RAT
Sequence: MASLAVSINQFAVEFSKKLAESAEGRNIFFSPWGISTSLAMVYLGTKGTTAAQMSQVLHFGSIQDFKFGPDSEKKRKMECHSGKSEEMQSDFQTLTAKILKHGNSYVLKIANRIYVEKTYLFHNKYLEDMKTYFGAEPQSVNFVEASGQIRKEINSWVGSQTGDKIPNLLPDDAVDNKTTMVLVNALYFKGTWEHQFSVQNTTERPFRINKTTSKPVQMMSMKQSLQVFHIEELQTIGVQLHYQNREFSLLLLLPEEVEGLKQLERAITYEKLDKWTSADMMDTYEVRLYLPKFKMEESYDLQSALRDMGMTDAFNQGKANFSNMTSERNLFLSNVFHKTFLEINEEGTEAAAGTGSEVNFRIKAPSIELNADHPFLFLIRHNVTNTILFDGRFYSP
What is the function of this protein?
Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF.  May regulate protease activities in the cytoplasm and in the nucleus (By similarity).  Inhibits plasmin.
What are the official names of this protein?
Serpin B10, TGF-beta-repressible serine proteinase inhibitor, Trespin, Transforming growth factor beta repressible serpin.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Ov-serpin subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MS18A_PLEMO
Sequence: MAGALSLRCRTGCTGGCEYGHKGKCRDSSLLSKRLSEDSSRHQLLQKWTSMWRSTSEDASVADTEKARLEEAAAAAEERPLVFLCSGCRRPLGDSLSWVTSQEDTNCILLRCVSCNVSVDKEQKLSKREKENGCILETLHCTGCSLNLGYVYRCTPKNLDYKRDLFCLNVEAVESYVLGSSEKQIVSEDKELFNLESRVEIEKSLKQMEDVLQALQMKLWEVESKLSFATCKS
What is the function of this protein?
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
What are the official names of this protein?
Protein Mis18-alpha.
What is the protein family that this protein belongs to?
Belongs to the mis18 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
Protein: CH60_CAEEL
Sequence: MLRLARKGLQTAVVRSYAKDVKFGAEGRQAMLVGVNLLADAVSVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIDLKDKYQNLGAKLIQDVANKANEEAGDGTTCATVLARAIAKEGFESIRQGGNAVEIRRGVMNAVEVVVAELKKISKKVTTPEEIAQVATISANGDTVVGNLISDAMKKVGTTGVITVKDGKTLNDELELIEGMKFDRGYISPYFITSAKGAKVEYEKALVLLSEKKISQVQDIVPALELANKLRRPLVIIAEDVDGEALTTLVLNRLKVGLQVVAIKAPGFGDNRKNTLKDMGIATGATIFGDDSNLIKIEDITANDLGEVDEVTITKDDTLLLRGRGDQTEIEKRIEHITDEIEQSTSDYEKEKLNERLAKLSKGVAVLKIGGGSEVEVGEKKDRVTDALCATRAAVEEGIVPGGGVALLRSLTALKNYKAANEDQQIGVNIVKKALTQPIATIVKNAGLEPSSIIDEVTGNSNTSYGYDALNGKFVDMFEAGIIDPTKVVRTALQDASGVASLLATTECVVTEIPKEEAVGGPAGGMGGMGGMGGMGGMGF
What is the function of this protein?
Implicated in mitochondrial protein import and macromolecular assembly.  May facilitate the correct folding of imported proteins.  May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity).
What are the official names of this protein?
Chaperonin homolog Hsp-60, mitochondrial, Heat shock protein 60, HSP-60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RS8_SULTO
Sequence: MVNLNPLANALTTIYNNEMRRNKQAIIMPASKLIINVLRAMQKEGYIGEFEFIDDGRSGKIVVQLLGRINKCGPIAPRYPLKYKDLLTLPDYVRRYLPSKEIGVLIISTNKGVMTHKDAIRERIGGVALGYVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: YCGN_ECOHS
Sequence: MAEHLMSDVPFWQSKTLDEMSDAEWESLCDGCGQCCLHKLMDEDTDEIYFTNVACRQLNIKTCQCRNYERRFEFEPDCIKLTRENLPTFEWLPMTCAYRLLAEGKDLPAWHPLLTGSKAAMHGERISVRHIAVKESEVIDWQDHILNKPDWAQ
What are the official names of this protein?
UPF0260 protein YcgN.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: CTAA_BACAA
Sequence: MQRFIKWLAVITSLDLLIVLLGGALVTKTGSGQGCGKSWPLCNGEFVPSNLSMETIIELSHRLTSGSAGILVTLLCILSWKYYKHVRETKTLAILSFVFLVAQALMGAAAVVWGQMPAVLAIHFGISLISFASVILLTCLIFEIDQKFDARSLIMDKKMKFHIYGVTIYCYLVVYTGALVRHERASLACPDFPLCSKNRPMPTQLHEWVQMGHRLAAMLIFVWILYAMILAIRHYKQQPVVYWGWIISFILVTLQAIVGILVVFTNASLAMALLHSLFISCLFAVLCYLVMLGTRSKVNAKEAASTSKQTK
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HBB_CHICK
Sequence: MVHWTAEEKQLITGLWGKVNVAECGAEALARLLIVYPWTQRFFASFGNLSSPTAILGNPMVRAHGKKVLTSFGDAVKNLDNIKNTFSQLSELHCDKLHVDPENFRLLGDILIIVLAAHFSKDFTPECQAAWQKLVRVVAHALARKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.  The beta chain is a component of adult hemoglobin A and D.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: IOLE_HISS2
Sequence: MKAENVKLGIAPIGWTNDDLPEIGKENTFEQCVSEMALAGFTGSEVGSKYPRDIDVLKRKLDLRGIQICNAWFSTFFVDGKKEETIKGFIEHRDFLHAMGAKVIGCSEQSRSIQGQKKAIFKEKTIFTEAEWQLLAEGYNELAKLAAEKGMKVCLHHHMGTGIQTPAEIDKYMEITNDDVYLLFDSGHLYYSEGSQQVMLEVLEKYIHRVVHVHLKDVRDEVVAEVKANDLSFLEGVVKGTFTVPGDGVIDFKPIFDILEKYDYKGWMVVEAEQDPAIANPLEYAIKGRQYIREVAGV
What is the function of this protein?
Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).
What are the official names of this protein?
Inosose dehydratase, 2-keto-myo-inositol dehydratase, 2KMI dehydratase.
What is the protein family that this protein belongs to?
Belongs to the IolE/MocC family.
Protein: DLGD_SALNS
Sequence: MKVTFEELKGAFYRVLRSRNIAEDTADKCAEMFARTTESGVYSHGVNRFPRFIQQLDNGDIIPDAKPQRVTSLGAIEQWDAQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLLSNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAIRLPGHEFTKLLDDNRRHGITIDDSVWAKIQAL
What is the function of this protein?
Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
What are the official names of this protein?
2,3-diketo-L-gulonate reductase, 2,3-DKG reductase, 3-dehydro-L-gulonate 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TLE3_HUMAN
Sequence: MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPIGIMASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
What is the function of this protein?
Transcriptional corepressor that binds to a number of transcription factors.  Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling.  The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
What are the official names of this protein?
Transducin-like enhancer protein 3, Enhancer of split groucho-like protein 3, ESG3.
What is the protein family that this protein belongs to?
Belongs to the WD repeat Groucho/TLE family.
Protein: BIOH_NITMU
Sequence: MGQVSLYVESLGEGPDLVLLHGWAMHSGMWGSTRRSLAQHFRLHLVDLPGHGFSRGALPYKRGEKNGVSEDMVERVVEVLPPDCVICGWSLGGQLAIELALREPARVEKIILTSTTPSFVKREDWQWGMEELTLKAFAENLRRDFSTTMKRFLTLQVSGGGDAGKVLPEMRRLLFERSAPEPEALEAGLQIVLANDLRGKLRNIVQPTLLIHGENDVIAHPEAAAWMKQQFQDVELAMLPNCSHVPFLSYPDKFIANIVRFAR
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_LACP7
Sequence: MQLLKDRIRKDGIVKQGNVLKVDSFLNHQMDIELINEIGKEFKRLFEKEKITKILTIEASGIGIACIVAQYFNVPVVFAKKAQSINIEGEVFATKIESFTHKKTYDVIVSKKFLKPSDRVLIIDDFLANGCALVGLIDLVISSGASVEGIGIVIEKGFQSGGEIIREMGIHLESLAIVDSMNAEDGTVVFRGDK
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSHB_XYLFT
Sequence: MPLDVVVVMDPITGIKIAKDTTFALLLEAQRRSHRLHYVHPGSLSLNEGRTFAQTAPLQVRDNKTDWYTLGEFSETQLGQGQIILMRKDPPVNAEFIYDTQLLSIAQAAGAQVINHPQGLRDLNEKIAAQLFPQCCPPTLISRDMRALKMFVQKQEQAILKPLDGMGGHSIFRSSNGDPNLNVILETLTDGGRTLAIAQRYLQQIIEGDKRILLIDGVPIDHCLARIPQGDEFRGNMAAGGRGESRPLNERDRWIAAQVGPEMRRRGMRFVGIDVIGDYLTEINVTSPTCLRELDAQCGLNIAGQLFDAIETGG
What are the official names of this protein?
Glutathione synthetase, GSH synthetase, GSH-S, GSHase, Glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic GSH synthase family.
Protein: GCH1_SALPK
Sequence: MPSLSKEAALVHDALVARGLETPLRPPMDELDNETRKSLIAGHMTEIMQLLNLDLSDDSLMETPHRIAKMYVDEIFAGLDYANFPKITLIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILTALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHP
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: RUTA_ECOKI
Sequence: MQTSHYAAEKDMQDAAPRLTFTLRDEERLMMKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGSGKSDFKGDFFTMDDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTFDDFLSGIENFGERIQPLMQCRAHLPALTQEVA
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
Protein: MSHD_CORK4
Sequence: MADAPTFNAQPCDIITQLVLGPVSPRVRNARQASADRWMEIETILHESTRHDGVAPFSEQFLRGMEEPDLNHWHALVRVDGHVRGIAAVDPSGPAVELAVHPSYRRGGLATALQRAVRAHASSLGLGDERDIHTNGIGLTWWAHGDLPPARAAAEHIGATADRELLVMELPGSVVKDESDNNPVAQAAATLPDDVTVLSWTESARRWGKDAVDAAWLAVNNEAFDWHPEQGGWDQARLDQARRASWYDPDGVLLLWGSEGDQKDGDTDSLPPLLGFHWTKLAREGDDETGRKVGEVYVIGLARKAQGRGLGRASTAKGIQYLASNDAAYVELYVEADNAPAVHAYEALGFTVVERHTAWKF
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: RL15E_NANEQ
Sequence: MGLYQYVRALYKDPKEFLGELYKQRIQQWRREPPIVEVERPTRIDRARALGYKPLPGIKIVRVRVRKGTRKREEIKGGRRPKAEYRIRPLGVNLQWIAEERANRLHRNMEVLGSYWVGEDGLYKWYEVILVDPFNPNIYNRPEYVWLLQKNQRGRVFRGKTSSARKFRGLRNGGLGAEKVRPSKRANFKD
What are the official names of this protein?
50S ribosomal protein L15e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
Protein: MEP2_ARTBE
Sequence: MHGLLLAGLAAALPLGVAGLPARQQSGLSPRGIDINPYRFASMAKYSEHKATSQMVHSFSYSKDDDYVATATKLVKSTFPNMTFRTVKDHYIGTNGIGHVHFKQTAHGIDIDNADFNVNIGRDGKVFTFGNSFYEGEMPKTNPLTKRDFADPVKALHGAIKTLKLPVKPQSAKAMPMKEAETFMFEGTSGALSEPMAKLVYIQKDGKLHLTWRVETDVGDNWLLSYVDSKETETVHNVVDYVASADYKVFAWGLNDPTEGQPTMIKDPWNTTGSGSPFTWHGDGEMDYTVTRGNNIAAQDNPSGGGQWENNYRPESPELSFVYEYNEQMEPEQFKDFAITQLFYTTNTFHDLLYSFGFTEEAGNFQMNNNGKGGEGNDFAICNAQDGSGTNNANFATPPDGQNGRMRMYTWTTAQPSRDGDLEAGIVIHEYAHGLSNRLCGGPANSNCLSELEAGGMGEGWGDFYATAIRLKQDDTRETDYTMGEWAANMEGGIREYPYSTNMQTNPYTYADVEGMSEVHGIGTVWATILYDVLWNLIDEHGMSKNIMPKFVNGAPSDGRNLAMKLVLDGMTLMPCNPNFVQARDAIIDADQALTNGQNKCALMKAFSKRGLGSNYKHGKNRVNNFDMPADC
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 2, Fungalysin MEP2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.