PharMolix/UniProtQA huggingface dataset:
Protein: FPG_ECOK1
Sequence: MPELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSEEIYRLSDQPVLSVQRRAKYLLLELPEGWIIIHLGMSGSLRILPEELPPEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTKELEGHNVLAHLGPEPLSDDFNGEYLHQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSLAECELLARVIKAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATFYCRQCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: YTXC_BACSU
Sequence: MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANPAFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADDLPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKMEQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDHPMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPVKHSEG
What are the official names of this protein?
Uncharacterized protein YtxC, ORF-281.
Protein: MTNC_THISH
Sequence: MTKIILTDIEGTTSSLSFVKDVLFPYAREHLPEFVRGHRDDTEVKRLLADARAYAGGDLDEEALIERMIGWIDNDQKITPLKALQGLIWEDGYARGDFQGHVYEDAVAHLRQWHQQGLRLAVYSSGSVHAQKLLFGHTAFGDLNPLFEAYFDTRIGGKRDTASYKAIAKELGVEPREVLFLSDLRAELDAAAEAGMKTTALDRAGNGEDFGPHPVARDFAGVGV
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: RBFA_HELPY
Sequence: MNAHKERLESNLLELLQEALASLNDSELNSLSVTKVECSKGKHHAYVFVLSSDHKILSKLKKAEGLIRQFVLQASGWFKCPKLSFVSDNSLEKQLRLDAIFNEIAKGKDND
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_BURM1
Sequence: MFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNPVGLAAGLDKDGAAIDGLAALGFGFIEVGTVTPRAQPGNPRPRMFRLPQAEALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKAIADTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGSAVPIIGVGGIFSGDDARAKLAAGASLVQLYTGFIYRGPALVAECVKAIARERAA
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CDPAS_METB6
Sequence: MVPAYIPNPVAALCGGGTPIDFCRNYTDGRRILGNGKTYRGLICGVLAGVLIGLVQIWLVGTYHWDLPRQTILSVTLLALGALLGDMGKSFIKRRLGKERGEAWPVADQYDLVVGAFLLTIIFDPAWFFAVVTLPVLIAILVITPVLHRSVNILGYWIKVKKEPW
What is the function of this protein?
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP.  This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
CDP-archaeol synthase, CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-archaeol synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YPFN_ECO81
Sequence: MDWLAKYWWILVIVFLVGVLLNVIKDLKRVDHKKFLANKPELPPHRDFNDKWDDDDDWPKKDQPKK
What are the official names of this protein?
UPF0370 protein YpfN.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SSEK1_SALTS
Sequence: MIPPLNRYVPALSKNELVKTVTNRDIQFTSFNGKDYPLCFLDEKTPLLFQWFERNPARFGKNDIPIINTEKNPYLNNIIKAATIEKERLIGIFVDGDFFPGQKDAFSKLEYDYENIKVIYRNDIDFSMYDKKLSEIYMENISKQESMPEEKRDCHLLQLLKKELSDIQEGNDSLIKSYLLDKGHGWFDFYRNMAMLKAGQLFLEADKVGCYDLSTNSGCIYLDADMIITEKLGGIYIPDGIAVHVERIDGRASMENGIIAVDRNNHPALLAGLEIMHTKFDADPYSDGVCNGIRKHFNYSLNEDYNSFCDFIEFKHDNIIMNTSQFTQSSWARHVQ
What is the function of this protein?
Protein-arginine N-acetylglucosaminyltransferase effector that disrupts TNF signaling in infected cells, including NF-kappa-B signaling, apoptosis and necroptosis (PubMed:32766249, PubMed:30327479).  Acts by catalyzing the transfer of a single N-acetylglucosamine (GlcNAc) to a conserved arginine residue in the death domain of host proteins TRADD and, to a lower extent, FADD: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNF-alpha receptor complex, thereby disrupting TNF signaling (PubMed:30902834, PubMed:32766249, PubMed:30327479).  Also acts on host proteins without a death domain: catalyzes arginine GlcNAcylation of host GAPDH protein, thereby preventing GAPDH interaction with TRAF2, leading to inhibit NF-kappa-B signaling (By similarity).  Catalyzes GlcNAcylation of host tubulin-folding cofactor TBCB, thereby promoting microtubule stability (By similarity).  Also mediates auto-GlcNAcylation, which is required for activity toward death domain-containing host target proteins (PubMed:32432056).
What are the official names of this protein?
Protein-arginine N-acetylglucosaminyltransferase SseK1, Arginine GlcNAcyltransferase SseK1, Salmonella secreted effector K1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase NleB family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm, host cytosol. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS).
Protein: LSPA_VIBVU
Sequence: MSGKAQIFKQTGVRWLWLALVVFLADIGIKFIVMENMGYGWANRIEVLPFFNLLYVHNYGAAFSFLSDQAGWQRWLFTGIAFVVTGLLTYWMSKLPAAEKWNNVAYAMIIGGAIGNVFDRMVHGFVVDYLDFYWGTYHWPAFNLADTAICLGAAMIILDGFRKKEEEK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEF7_NPVAC
Sequence: MSSVTKRPRAKRIRLPLEIIDTILQYLDPILHAKVVGLTTRVKCRLLRDNNVEDYLKLTPASYHPTTDQFICNYLGITNQPMAPYLVPLLSFGKASCVFFNKCIPEDVRIVTLNWPLPLLENFLSKQFLWYKLARKLIEHERRMDRCVTPSTVQINLYDDNEDYLNCFNCFNCCKDNLVSFNCCIVDCNINDMNRCPDLQIDVYLDDNIISLYLYFLFRIYRIVKE
What is the function of this protein?
F-box protein that manipulates the host DNA damage response (DRR) in order to promote viral multiplication.  Acts as a substrate recognition component of SKP1/Cullin/F-box (SCF) complexes for targeted protein polyubiquitination.
What are the official names of this protein?
Late expression factor 7.
What are the subcellular locations of this protein?
Host nucleus.
Protein: YIDD_METCA
Sequence: MQRLLITLIRLYQYLLSPWLGHHCRFFPTCSNYAMDAIGRFGAMRGAYLTIRRLMRCHPWHPGGIDPVPEKLGKQ
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CBLN3_BOVIN
Sequence: MLGTKRHWPPGPSLSLELPLALTLLALRAGWAQEGTEPVLLEGECLVVCEPGRAAAGGPGGAALGEAPPGRVAFAAVRSHHHEPAGEIGNGTSGAIYFDQVLVNEGGGFDRTSGSFVAPVRGVYSFRFHVVKVYNRQTVQVSLMLNTWPVVSAFANDPDVTREAATSSVLLPLDPGDRVSLRLRRGNLLGGWKYSSFSGFLIFPL
What is the function of this protein?
May be involved in synaptic functions in the CNS.
What are the official names of this protein?
Cerebellin-3.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network. Secreted. Synapse. Note=In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on an association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity).
Protein: GATD_METS5
Sequence: MLEGYRGKALELLSSLGAEIGDVLQVYNDKVSVKGILMPSYSRDDSVIVLKLDNGYNAGFSVNKVKVSLLEKGNRPQERSEHRELLPGKVKIISTGGTIVSKVEYETGAVRPALSTEEIIRFVPEIQEITSISAEILFSILSENMKPEFWVKIAEAVKRAFDEGSEGVVVAHGTDTMSYTAAALAFSIQRLPGPVVLVGSQRSSDRPSSDSGINLVSSVLLAKEAPFGEVVVNMHGESSDTYTLAHRGVKVRKMHTSRRDAFQSINDHPLAKVLWKERTVKVLRNDYLRRSDGVELNPKFENRVFLLKFYPGLRPDIVDILLSSGYRGIIVEGTGLGHTSSDFQEAFKRAVKEGLFVGMTSQCLFGRVNMNVYQTGRLLQQSGVVPLGDMLPEVALVKLMWALGQTSDLEEVKRIMLTNLVGEYNPRHSLDHFPRWKHE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit D, Glu-ADT subunit D.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family. GatD subfamily.
Protein: NLRC4_XENTR
Sequence: MDLIRKNYAELVQRMGRTIAVQITNDLFTRNILSMGEMEEILSCKVAQDLTRELLNVILKKGTESCTRLLQSLENQDPFFYEDLIGQRVQSGVTEEDLENLADHLKRLYQYPFFKKFNPLGEDTDIDIIFDLDRTFTDPLLWRKGTLNRREKQLTLSEMLEQLESPCVIEGEAGKGKTTILKRIAMLWASEKCRALADFKLVFFVTLRGASEGLYETLSDQLFPITYSWNKKEFLNKIWHLGRKVLFLLDGYDEFQSESCTEIEELIKNNPKFNSTVIVSTRTETIGKLRRCGALIAETSDFSLDNAKQLIANVLEEDEANGLLFQLEESSFMQNLMKTPLFVVIACALRMGESDFQMNTQTTLFSTLYDLMVEKKKYKIRHLSANILAANIRKFGDLALDGLFEQRFDFNEKHLSKIKEEVLLNIGLLNKYTAQRRKAVYRYFHTTFQEYIAGRRLSQLLSSEDNSDVTKGEDFLNKIVSVFDITTKYKNLLLYTCGSSKVATQKVVKHVAEVHKHDKNNYSTELVEFGLNLFFESSTKKELSQDFETLFSEKCLYINSHNISSHHIEFFLYLPNCLSALQLIKLDLSGTFATVPSESTMDRDSKSAQSSVCDNYIPEKAVKLFFDWNQSIQTLEVTLRDFHQLNKKDIKYLGKICCSADSLRLNIKRSSGITGSLVGVLESCKNIQDLNVDSTKLSIEDERRIVQMTEMKTLSILNLHSEHLQGGLLEGLCNLVGLEKLVFHNIKIDKNDAKTLAEGILSLKKLKRLSISHISNIGDGMESIAESISLCCHELKELKLIDCCLSAKALRSLGQSLYSLSHIEILDLSGNYLLEEGKESVEELAANLTHLDAIRTLMLPGGTDVKFCLEAVLPTLRRIPTLSELAFKRWNLTNDDLMTLASYINSGFENLSFLDLSDNCAQSAGWLSLTAILQYLPNLTYVNFSTEDLFTPDPDLVRKLVRAISALPLLHTMELNNWQLDDFDLAQIKKAKNMIHR
What is the function of this protein?
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.
What are the official names of this protein?
NLR family CARD domain-containing protein 4, Ice protease-activating factor, Ipaf.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: SYGB_BRADU
Sequence: MPDLLLELFSEEIPARMQAKAADDLRRMVTDKLVAEGLVYEGAKAFATPRRLALTVHGIPARQPDLKTERRGPKMGAPDAAVQGFLKATGLKSLDEAKIQRDPKGDFYIALIEKPGRDAIDVLAEILPVIIRTFPWPKSMRWGARSGKPGSLNWVRPLHAITATFGLETEEPDVVKFAVDGIEAGQTTYGHRFLAPAAINVRRFEDYEAKLLDAKVVLDPERRKDAILTDAKQLAFAQGFDLVEDQNLLDEVAGLVEWPVVLMGSFEEEFLATPAEVIRATIRNNQKCFVVSDAKTGKLANKFILVANIEATDGGKTIIAGNERVIRARLSDAKFFYETDLKTKLEDRLPKFEQIVFHEELGTQAARITRIERLAAEIAPLVGADVAKTARAAHLAKADLLTEVVGEFPEVQGLMGKYYALAQGEDASVAAACEEHYKPQGPADRVPTDPVSVAVALADKLDTLVGFWAIDEKPTGSKDPYALRRAALGVIRLIAENTLRLSLMKVAASALAGLSVKPADVQKLPGDLLTFFADRLKVQLREQGARHDLVDAVFALGGQDDLLMIVRRVDALGKFLESDDGKNLLAGTKRASNILSIEEKKDKRTFDGAPDAALYSLGEEKALAKAISEVQAEASASVAKEDFAAAMSAMAKLRPPVDAFFDKVRVNDDDPKVRENRLKLLNEIRSATRAVADFSKIQD
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METAS_PROMH
Sequence: MPIRVPDELPAVSCLRNENVFVMTSSRASIQDIRPLKVLLLNLMPKKIETENQFLRLLSNSPLQIDIQLLRIDSRVPKNTPVEHLDTFYCDFAQIKEQNFDGLIVTGAPLGLVEFEDVAYWEEIKEIITWAKEHVTSTLFICWAAQAGLNILYDLPKYTLKQKISGVYRHTTCDPFALLTRGFDETFFAPHSRYAGFPVEFIQQNTDLEILATSEQAGAYLFASKDKRVVFATGHPEYDPNTLADEYHRDVKAGLAPQLPENYFPDNNPNKKPLVSWRSHGHLLFANWLNYYVYQITPFDLAQMNPTLD
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P28B_VACCW
Sequence: MKLFTQNDRYFGLLDSCTHIFCITCINIWHKTRRETGASDNCPICRTRFRNITMSKFYKLVN
What are the official names of this protein?
Zinc finger-containing protein P28b.
Protein: MLAC1_METAF
Sequence: MSRFARLLLIVALFFTSAWAKTVKETLRITWEEGAPNGQARELIYTNGQFPSPTLVWDEDDDIEVTVYNEMAKNVTVHWHGLDQKDTPWSDGTPGLSQRPIQPGNKFVYRFKASPPGNHWYHSHEKMSLVDGLYGAIHIRPKGDRTGLWSQISQDKDDIKAMENAAYDPEYLVVSDWSQYTSEEYWKISTDSGLLVFCLDSILVNGKGEVYCPGQKFLQAELAPGLVEDAFPPGTEVSDKGCFPADLDQVQGGPWNITKRPDLIPPRVQEGCVASRHENATIVVDPSKNNGWVSMHFVAAATIAQITFSVDSHEFWLYEIDGNYVNPRKFVSAVMSAGETFSVMIKLDQEPGKYTMRIPNSGASQVLGGFAEMVYKGCEHEEKAGKAYLSYGGNPTSPDVEKNSFFPWQLDTDHMSPWPPNKPRPGNADEEHLLVLGRVGAPYNYTMNTKYLYPVDFQNDDPLLFYPNATRDTENDGLVLRTKNGSWVDLILQVSTLPGDTSSFEHFMHKHGSKTWRIGFGTGVWNYTSVEEAIQERPQDFNLETPGLRDTWITAFSIGGEAYWSVFRYFVDNPGPWLFHCHIELHLMGGMGIAILDGVDAWPEHIPEEYQC
What is the function of this protein?
Laccase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:20382249, PubMed:29958281).  The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (Probable).  The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (PubMed:20382249) (Probable).
What are the official names of this protein?
Laccase 1, Conidial pigment biosynthesis oxidase Mlac1.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Cell surface.
Protein: LEU1_KINRD
Sequence: MQNTQTPSPMPFGKYTPFQDQIRVELPDRTWPTRTITKAPRWCAVDLRDGNQALIDPMNSERKLRMFTLLVQMGYKDIEVGFPSASQTDFDFVRTLIENDLIPDDVRIQVLTQAREHLIERTYESLRGAKQAIVHLYNSTSVLQRRVVFGMDEDGIVDLALQGARLCRKFEETIPGTTVYYEYSPESYTGTELEFAARICNAVVAVFEPTPERQVIVNLPATVEMATPNVYADSIEWMSRHLDQRENVIISLHPHNDRGTGVAAAELGYLAGADRIEGCLFGNGERTGNVDLVTLGMNLFSQGIDPQIDFSDIDHIRRTVEHCNQLPVGERVPYGGDLVFTAFSGSHQDAIKKGLEAMERDAAAAGKTVDEIPWAVPYLPIDPRDVGRSYEAVIRVNSQSGKGGVAYLLKAEHQLDLPRRLQIEFSRVIQERTDAQGGEVSAAQIFDVFSDEYLPSGSGTPEWGRFALRGTRSVSVVDGADTLEVDLHDDGAENTVRGTGNGPIAAFCAALGSRGVDVRVLDYAEHALSAGGDAQAAAYVECAVAGRVLWGVGIDHNITTASLKAIVSAVNRALR
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: DNLJ_ERYLH
Sequence: MTTELENLSEAEAANELMRLARQIAKHDRLYHAEDAPEITDQEYDALVRRNAELEAAFPHLVREDSPSRKVGHAVAASPLSKVTHEVRMMSLDNAFADEEVAEFVARVRRYLNIGEDEAIAFTAEDKIDGLSCSLRYENGKLVRAATRGDGQVGEDVTPNVAHIGDIPQELTPLPLAGGAGGGPLDDSGSAPTPDPSRRREGKWNGPAVFEIRGEVYMATADFHALNARLMDEARAEADEKDNAFDTAKVRQFANPRNAAAGSLRQKDASVTATRPLRFWAHGWGAVEGDVPGETQVEVVEQIAAWGVPVSPLFRRCETLEEMLAHYEAIGAQRADLPYEIDGVVYKVDRLDYQQRLGFVAKAPRWAIARKFPAEQAETTLENIDIQVGRTGKLTPVGRLAPVLVGGVTVTNVTLHNRDEIERLGVRPGDRVVVQRAGDVIPQVVRNLTPDEKRDSFEFPDTCPECGSEAVSEEGGVDVRCTGGLICPAQRTERLKHFVSRAALDIDGLGEKTIDQFFALGWLESPADIFRLKDRRDEILALEGWMDKSVDNLLASVEARREPDTARLLLGLGIRHVGAVTARDLMKYFHELPALRETAEKARAGDEEAVVALTSIDGIGSAVVEALGDFFHEEHNRAVWDDLLSEVSPPRYEVETLDSPVAGKTVVFTGKLETMSRDEAKAQAERLGAKASGSVSAKTDLLVAGPGAGSKLKKAQDLGIEVIDEAGWAEIVAAAG
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: MS116_ASHGO
Sequence: MFRVTGIATARAVALQPFRAPLGVIRRFGISATASYEFQHGHDMQSRNGSRWDSRRQGDRRSSRWEGRGSDREDGERGSRGGMWRKPQGRRGRTDGAAREGFSLGPNTEVVRVADEAAGVESTPRTLVEEGVLSNELYEMLQSRGFDKLTPVQQKTLKPILQTEHDVVARAKTGTGKTLAFLMPLFQRLLEGPPSENVKAVVIAPTRDLAAQIFNEINEMRNANRKLRRFNAVVMMGGSSRTETFRSLERRRPNIVVATPGRLIDMLEACGPKYFTEVDFKVLDEADTLLEIGFKQALEQINDILNQLNQKGTTHIRTLLVSATLDDKVQSLANSIMNHAKCLFIDTVDPNEQATNENIAQKVVISKDFADNITASLYKIREEASANPKLKAIVFMPTIVAVEYWGELLQSQCRGTPVLLFHGGLSQGRRNSTMKRFRAMDSGILVCTDVAARGMDVSDVQHVYQVGVPTSPDNYIHRIGRTGRAGRKGSSTIFLAEHELCILDILRRKNNVVISDQETFDAAAQELSDVREAFSLDRDRLHDFLLKNLSFYRGSQGEYDFPLEAYISIARAYGTLLGDSNQRLTLSGRMLTTFVPNHPAVCSLFNIIGPVNSKSSYGFRDTNKRHRRGRLDDSGRLEYSKKRHSYARSYSPSISDGF
What is the function of this protein?
ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns.  Also required for efficient mitochondrial translation (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase MSS116, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: VPS10_ARTOC
Sequence: MIIRSILLAGSLLLASAIPGTLAKSDEPEIKVKELDKVPTSIYYFEDTDTIIFQKGLGEIYISTDAASSWEVMKDKTGLLWLNRHHTQSACIVGDKRKHWVTYDAAKTWREFEVPDKLILGERIQPFVFHGKDSNKAIINAEECLLTGCRRVTYYTVDGFKTIKKLLQDDSGCYWAVGHPNVGEGLDIRKKIDDRIFCILPGALPFNSSPRLVYSDKFFSDDMAIPVEINGRELRGINKFAFVKKFLVIATVSDGTSEAAIYVSRDAMHWDRAEFYGGPKVREGKFTFLESTNYSIQVNVASRRSKLPIGSLYTSDSTGTSFTMNVDSVNEDKDMYTDFEQVSGIQGIFLINRVDNAEEVKTGKASEKKIVSRISFDDGRTFKPLKYKDKEIHLHSITRPSNSGRTFSSPAPGLVMGVGNSGDRLKEYEHGNLYVSDDAGITWRKALDKAHKYEFGDQGSLLVAIFDEAGGDKIYTDEISYSLNHGKDWKKVKLPHTFLLLAEDKNKKFYVMSIDFSGLHERKCGKNDFERWAARLDEKGEPDCLMGHKQFYRRRKADADCFVKEKFKEPLPEIEPCKCTKEDFECAAGFKRNNDYDCEPDGKLKPSEGQCKKPDDKFMGPSGYRLIPGDDCIKKGGVDLEKEVERACKETSKGPISGKIAVEATPFETEGFQYRYLERSDTSSGDDETVIFKTDKGEIFVSKDHGKSWGRGKFKEPILEFMPHKYDKDVIYLLTGSKKAYWSIDRGHSFHAFEAKMPFTRTLGSLPLFFHPDRPDWLIWIGGEGCSGKKCNDVAYYSKNRGDEWELLLRGVNKCMFVGKEGELTNDDLIFCSQHEGEDPHKDMRLVSSDTMFSKKTSIHFDGKPIAGFTKMSEFIVVATKNGSELQSFTSVDGKTFAHAAFPPNFHVDFEHAYTVLDSSTHSVFLHVTEHAARGHEFGSILKSNSNGTSYVLSLNGANRNVKDYVDFEKIQVVEGVALGNVVFNTEEVKKKNEEKKFRSMITHNDASEWALLPPPKKDVDGHSFGCKVTDKGTNDCALHLHGYTERRDNRDSMSSGSAVGLIIGVGNVGSHLTARAESDTFMSRDAGITWHQIRKGRYQWEFGDQGSIIVIVAEGKPTKVLSYTLDEGETWTDFEFTDAEVTVEDISTVPSDTSKNFLLWTKKGSTTDLVVYNIDFSGLKERERQCVLKKDAPEADDYYLWSPKHPMQKDNCLFGHVSLYHRKKPDAKCYNGPRLDRLSSEKKNCECTRQDYECDYNYERQTDGSCALVKGLKPADPMQICKADPDAVEYFEPTGYRKLPVSTCEGGVQLDHIVARPCPNKKKEFEKKHPGISGLGLFLAIFFPLATAAAVGYWAFSKWDGKFGRIRLGESQPESIFSGDSPLIAIPVTIVAGTVAVITALPLLFSSLWRSVRGYTRLPGRWRQRPYASRGAFAARRGDYVGVVDDEDELLGAEEFEGDEEDEV
What is the function of this protein?
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.  Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
What are the official names of this protein?
Vacuolar protein sorting/targeting protein 10, Carboxypeptidase Y receptor, CPY receptor, Sortilin VPS10, Vacuolar carboxypeptidase sorting receptor VPS10.
What is the protein family that this protein belongs to?
Belongs to the VPS10-related sortilin family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Protein: PYRG_SALHS
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQLAVDIGREHALFMHLTLVPYLAAAGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISMKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLSEWEQVIYEEANPAGEVTIGMVGKYIELPDAYKSVIEALKHGGLKNRVTVNIKLIDSQDVETRGVEILKDLDAILIPGGFGYRGVEGKIATARYARENNIPYLGICLGMQVALIEFARNVAGMDNANSTEFVPDCKYPVVALITEWRDEDGNVEVRSEKSDLGGTMRLGAQQCQLSDDSLVRQLYGASTIVERHRHRYEVNNMLLKQIEAAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAANEHQKRQAK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.