PharMolix/UniProtQA huggingface dataset:
Protein: GLPO_ENTCA
Sequence: MTFSQKDRKETIQETAKTTYDVLIIGGGITGAGVAVQTAAAGMKTVLLEMQDFAEGTSSRSTKLVHGGIRYLKTFDVEVVADTVRERAIVQQIAPHIPKPDPMLLPIYDEPGATFSLFSVKVAMDLYDRLANVTGSKYENYLLTKEEVLAREPQLQAENLVGGGVYLDFRNNDARLVIENIKRAQADGAAMISKAKVVGILHDEQGIINGVEVEDQLTNERFEVHAKVVINTTGPWSDIVRQLDKNDELPPQMRPTKGVHLVVDREKLKVPQPTYFDTGKNDGRMVFVVPRENKTYFGTTDTDYTGDFAHPTVTQEDVDYLLTIVNERFPHAQITLDDIEASWAGLRPLITNNGGSDYNGGGKGKLSDESFEQIVESVKEYLADERQRPVVEKAVKQAQERVEASKVDPSQVSRGSSLERSKDGLLTLAGGKITDYRLMAEGAVKRINELLQESGASFELVDSTTYPVSGGELDAANVEEELAKLADQAQTAGFNEAAATYLAHLYGSNLPQVLNYKTKFEGLDEKESTALNYSLHEEMVLTPVDYLLRRTNHILFMRDTLDDVKAGVVAAMTDFFGWSEEEKAAHVLELNQVIAESDLTALKGGKKDE
What are the official names of this protein?
Alpha-glycerophosphate oxidase, Glycerol-3-phosphate oxidase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YORY_BACSU
Sequence: MKDIVRDLVIDDIDAAEGVLDKLYVYLENTLRPEEKRVWERCDKDIMSVFAKLKNIKEII
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YorY.
Protein: SLYB_CALRH
Sequence: MGRFIFVSFGLLVVFLSLSGTGADCPSGWSSYEGHCYKPFNEPKNWADAERFCKLQPKHSHLVSFQSAEEADFVVKLTRPRLKANLVWMGLSNIWHGCNWQWSDGARLNYKDWQEQSECLAFRGVHTEWLNMDCSSTCSFVCKFKA
What is the function of this protein?
Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2).  Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLCgamma2, and platelet activation and aggregation.  Binding to GPIbalpha (GP1BA) and alpha2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial.
What are the official names of this protein?
Snaclec rhodocytin subunit beta, Aggretin beta chain, Rhodoaggretin subunit beta.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS8_BACC2
Sequence: MVMTDPIADMLTRIRNANMVRHEKLEVPASKIKKEIAELLKREGFIRDVEYIEDNKQGILRIFLKYGANNERVITGLKRISKPGLRVYAKADEVPRVLNGLGIALVSTSKGVMTDKDARQLQTGGEVVAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: 4CLL1_ARATH
Sequence: MESQKQEDNEYIFRSLYPSVPIPDKLTLPEFVLQGVEEYTENVAFVEAVTGKAVTYGDVVRDTKRLAKALTSLGLRKGQVMVVVLPNVAEYGIIALGIMSAGGVFSGANPTALVSEIKKQVEASGARGIITDATNYEKVKSLGLPVIVLGEEKIEGAVNWKDLLEAGDKCGDTDNEEILQTDLCALPFSSGTTGLQKGVMLTHRNLIANLCSTLFGVRSEMIGQIVTLGLIPFFHIYGIVGICCATMKNKGKVVAMSRYDLRIFLNALIAHEVSFAPIVPPIILNLVKNPIVDEFDLSKLKLQSVMTAAAPLAPELLTAFEAKFPNVQVQEAYGLTEHSCITLTHGDPEKGQGIAKRNSVGFILPNLEVKFIDPDTGRSLPKNTSGELCVRSQCVMQGYFMNKEETDKTIDEQGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDVAVVPLPDEEAGEIPAACVVINPKATEKEEDILNFVAANVAHYKKVRAVHFVDSIPKSLSGKIMRRLLRDKILSINKK
What is the function of this protein?
Carboxylate--CoA ligase that may use 4-coumarate as substrate.  Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.
What are the official names of this protein?
4-coumarate--CoA ligase-like 1, 4-coumarate--CoA ligase isoform 10, At4CL10.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: COBQ_CLOB8
Sequence: MDKKSIMFLGTASSVGKSTLVTALCRYLKNQGLNVAPFKALNISLNSYVTKDGLEMGRAQVVQAEACKLEADALMNPVLLKPSGEYTQVIADGKVFCNIEPYKYKELNETLKVRVKKAYDKLSKKHDVIVLEGSGSCAEINLKDSDISNMAMAEIADAPVILVSDIDRGGVFASIVGTIQLLPESERERIKGVIINKFRGNIELFKPAIKQLEDIINIPVLGVMPYEKFDIDDEDSVTERIRNKEEVGTLDIAIIRLSHMSNFTDFSILDRIPDVTIRYVDKPSELKNPNLIIIPGTKNTIEDLRSMKENKLFDKIKELKESGTPILGICGGYQMLGTLILDKLGVEGNISQEDGFGFLDIKTRFNETKVTKQTKGNILCDLKSIKSIEGSTISGYEIHNGISKIGKKAIPFIKDLDGDIVGVCDKERIVAGTYLHGMFDSEEFISSFVKSLKENNDIVVTEDIIIEKVNEYKDNEYDRLSKLFEENIDIYQLRKIMEL
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: H2B7_ORYSI
Sequence: MAPKAEKKPAAKKPAEEEPAAEKAEKAPAGKKPKAEKRLPAGKGEKGSGEGKKAGRKKGKKSVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAGESAKLARYNKKPTITSREIQTSVRLVLPGELAKHAVSEGTKAVTKFTSA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.7.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MNMA_LACH4
Sequence: MVDNSKTRVVVGMSGGVDSSVSALLLKQQGYDVVGVFMKNWDDTDDSGVCTATEDYEDVKKVADKIGIPYYSINFEKEYWHRVFEYFLNEYKKGRTPNPDVMCNSQIKFKSFLDFAMDLDADYIAMGHYAKTVKDADGLTHMMRPKDGNKDQTYFLSQLNQDQIKKVIFPLANLTKPQVREIALANGLATAKKKDSTGICFIGERNFRKFLSEFLPAKSGKMVTPDGKVVGEHAGLMYYTIGQRQGLGLGSTKESTDPWFVVGKDLKKNELIVEQGYDSKLLYASRLKASDMSFFTGKPDHDVEFHCSAKFRYRQCDVGVTVKYHADDNTADVYFDEPARAVTPGQALVLYQGEECLGGGNIDAAYQEDKQLQLV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESXV_MYCTO
Sequence: MTINYQFGDVDAHGAMIRALAGLLEAEHQAIISDVLTASDFWGGAGSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA
What are the official names of this protein?
ESAT-6-like protein EsxV.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. ESAT-6 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX-5 / type VII secretion system (T7SS).
Protein: MAND2_CAUSK
Sequence: MPKITAARVVVTCPGRNFVTLKIETSDGVYGVGDATLNGRELPVVSYLTDHVIPCLIGRDAHRIEDIWQYLYKGAYWRRGPVTMAAIAAVDMALWDIKAKIAGLPLYQLLGGACREGIMVYGHANGATIEETLENAAVYAAQGYKAIRLQSGVPGLKGVYGVSKDKFFYEPADGDLPTESLWSTEKYLRSAPGLFEAARDKLGWDLHLLHDVHHRLTPIEAGRLGKDLEPYRPFWMEDAVPAENQASFRLIRQHTTTPLAVGEVFNSIWDCKQLIEEQLIDYIRATVVHAGGITHLRKIASFADLHHVRTGCHGATDLSPIAMAAALHFDLSIPNFGIQEYMRHTEATDTVFPHAYTFNDGMLHPGDAVGLGVDINETEAAKYPYKRAYLPIARREDGSMHDW
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.  Has no detectable activity with a panel of 70 other acid sugars (in vitro).
What are the official names of this protein?
D-mannonate dehydratase Caul1835, ManD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: MNMC_AERS4
Sequence: MSQTSLHHARLDWNEAGTPVSSDFGDVYFSNDNGLSETRYVFLQQNGLPARFSHHNSDSFVIGETGFGTGLNFLATMKAFLEQAPQTGNGARLHFISFEKFPLTRDDLHKALTAWPELAPFSQALIAQWPLPVPGCHRLHFAGGRIRLDLWLGDIKEMLPQVPHGEQGLVDTWYLDGFAPAKNPEMWTQDLFDGLARLARPGATLSTFTSAGFVRRGLIAAGFAMKKVKGHGSKWAMLAGERVDKKPQRTIVPWYARPAGRDGEVVIIGGGIASAMTALSLVERGRKVTLLCEDHELATGASGNRQGALYPLLNGEHDALSRFYSLAFGYARQRLLSLAKHHPIAFDLCGVVQLGYDDKSTAKLAKMQQGPFPHALMRPLTPVEAEHECGLPSGHAGVSYPLGGWLCPADLTRAAIKEAQASGLLQVEYDCPVTAIHEQVDGWLVASREGRQWQAPNLVVAAGHQLPALSPFAELPLYPVRGQVSHVPTTATLSQLKTVLCYDGYLTPAHNAEHCIGASYGRNQSTQAFSAEEQAQNQARLQACLPDQAWPAEVDVSSNEARVGVRCASRDHLPVAGPIARLAGLADHYARLQRDQQNPAPLPLHPGLYVLGALGSRGLCSAPLCGELIASEICGDPLPLATDLLEALHPARYWIRKLLKGKPLN
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFD_PSEA8
Sequence: MALPRPTSPHARGSNRTPAIMRLVLGACVPGLLTLTWLYGPGTLLNLAWASLVALACEAAMLALRKRPPGVFLKDGSALVTALLLAVALPPYAPWWLTLVATFFALVFGKHLYGGLGQNPFNPAMLGYVVALVSFPLEMTRWPSPDSALGLPDSLREFLGLATRPDAWAHATALDVLKTDRSLTVDELFAGNPAFGHLGSAGSEWVNLAFLLGGLFLLWRRLFTWHAPLGMLAGLFAMSLLFWNGSGSDSHGSPLFHLFSGATMLGAFFIVTDPVSGATSNRGRLVFGLGVGVLTYVIRAWGGYPDGMAFAVLLMNLAAPTIDYYTRPRTYGHRKAERGFKAGD
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRUB_SHEPW
Sequence: MARRSRGRHIDGVLLLDKDTGMSSNFALQRVKRFFNANKAGHTGALDPLATGMLPICLGEATKFSQHLLDADKRYLVTAKLGQRTDTSDSDGEVVQTREIDFTQEQLDTALEYFRGKTMQVPSMYSALKYQGQPLYKYAREGIEVPREARPINVFELNFISLEGDELTLDIHCSKGTYIRTITDDLGEMLGCGAHVIMLRRTQVAGYPYDNMVSLAELEALVTKVEAESLTLAEVLDPLLLPMDTAVSDFKEINVSDDIAPFLMNGNPVQVANLPVDELVRITLGVERRFVGIGQMNDDGLLAPKRLIVLRDEAAQ
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RRF1_SCHPO
Sequence: MFRIISKATLFQDSQRFHTSILSPRCAFHNGGILHKKAKDKDVKHDHDPEFANSFNKMLKSFEAKMQLVHEKLAKRFQEAVVLPSQGNFTQLEALFIPSKSIKAPTPSRLLREIAAVSQKGSQQIIIRPFEDVDIKNILKAIEDSRYPFVANKLNASTIEVKPQRTTLESRQQLAKVLEGYAKDSREQLSAMRTELKKEIAKNKKSKAWTSDDCYKAEAEMQTAFKNAINLLDSGLKSALKKVI
What is the function of this protein?
Necessary for protein synthesis in mitochondria.  Functions as a ribosome recycling factor in mitochondria.
What are the official names of this protein?
Putative ribosomal recycling factor, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
Protein: PSPA_MYCTU
Sequence: MANPFVKAWKYLMALFSSKIDEHADPKVQIQQAIEEAQRTHQALTQQAAQVIGNQRQLEMRLNRQLADIEKLQVNVRQALTLADQATAAGDAAKATEYNNAAEAFAAQLVTAEQSVEDLKTLHDQALSAAAQAKKAVERNAMVLQQKIAERTKLLSQLEQAKMQEQVSASLRSMSELAAPGNTPSLDEVRDKIERRYANAIGSAELAESSVQGRMLEVEQAGIQMAGHSRLEQIRASMRGEALPAGGTTATPRPATETSGGAIAEQPYGQ
What is the function of this protein?
Involved in resistance to stress (PubMed:25899163, PubMed:27002134).  Facilitates intracellular growth of M. tuberculosis (PubMed:25899163).  Associates with and regulates lipid droplets (LDs) homeostasis under conditions of stress and may regulate non-replicating persistence (NRP) (PubMed:27002134).  Could be involved in preservation of envelope integrity and tolerance to surface stress (PubMed:25899163).  Has an inhibitory effect on ClgR activity (PubMed:25899163).  May block ClgR activity after stress and then, form a multiprotein complex with Rv2743c-Rv2742c, leading to the release of ClgR (PubMed:25899163).
What are the official names of this protein?
PspA protein, 35 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PspA/IM30 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the surface of lipid droplets (LDs).
Protein: ANKZ1_HUMAN
Sequence: MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAPRTSCSGSGERESPERKLLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSSTGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRCVLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPRSGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLHSPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQAGRPSS
What is the function of this protein?
Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725).  Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity).
What are the official names of this protein?
Ankyrin repeat and zinc finger domain-containing protein 1, Zinc finger protein 744.
What is the protein family that this protein belongs to?
Belongs to the ANKZF1/VMS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Translocates to the mitochondria upon exposure to hydrogen peroxide.
Protein: END4_TRIL1
Sequence: MSDYLGAHMSIAGGLHKSVERAVAAGCGTLQIFTRSSNQWKGKPVSDKDADLFRSSFAASGLHEVISHDIYLINLAAPAGDTRDKSLAAFGDEMATCARLGINKIVMHPGSHTTDSPEAGLERVISAFDQLFEQTPEYEGLVLLETTAGQGTNLGRTFEELQTIINGSKYPDRFGICFDTCHTFAAGYNTATPEGYADVMAQFDRLLGLERLLCFHFNDSKKGLGSRVDRHEHIGQGTLGLEPFRFIMHDPRFITVPKILETPKGDDDAMDQVNLALLRSL
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: SCNA1_TITCE
Sequence: KDGYIIEHRGCKYSCFFGSSSWCNKECTLKKGSSGYCAWPACWCYGLPDSVKIFDSNNNKCSKK
What is the function of this protein?
Inhibits the sodium (Nav) currents in an apparent irreversible manner (By similarity).  Produces small depolarization and induces repetitive firing in squid axons (By similarity).  Is specific for arthropods (crickets, triatomides, crabs and squids), but is non-toxic to mice (By similarity).  Shows antibacterial activity against both Gram-positive and Gram-negative bacteria (By similarity).
What are the official names of this protein?
Toxin Tce3.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PUB53_ARATH
Sequence: MDSFFKNSYLDPKAVRAQLPKRADLAAPSEPMTVALAISGSIKSKNVIKWALNKFGSDKNVTFKLIHIHPKITTLPTASGNIVSISEELEEVAAAYRQKVMQETKETLLKPFKKMCERKKLKIDETRFESSLTKVAVELQVLESNSVAVAITKEVNQHLISNLIIGRSSQAASSRNYDITASISASVSNLCTVYVVSNGGVHILAKDTSDTERNDTSIESGFERTSSSCSSGSGANSDVMSNALKSNPHTLSNKRMQNLPTIVRGVSVPMETSSTESDETKKRSSDAAEEASKRSSPETSRSVSWNPQFRDFDERKDAMSSMSSNFEYGNVVTPLGHYFTDNQDTLNEISKLRAELRHAHEMYAVAQVETLDASRKLNELKFEELTLLEHETKGIAKKETEKFEQKRREEREAAQRREAEMKATHEAKEKEKLEESSLVAPKLQYQEFTWEEIINATSSFSEDLKIGMGAYGDVYKCNLHHTIAAVKVLHSAESSLSKQFDQELEILSKIRHPHLVLLLGACPDHGALVYEYMENGSLEDRLFQVNDSQPIPWFVRLRIAWEVASALVFLHKSKPTPIIHRDLKPANILLNHNFVSKVGDVGLSTMIQAADPLSTKFTMYKQTSPVGTLCYIDPEYQRTGRISPKSDVYAFGMIILQLLTGQQAMALTYTVETAMENNNDDELIQILDEKAGNWPIEETRQLAALALQCTELRSKDRPDLEDQILPVLESLKKVADKARNSLSAAPSQPPSHFFCPLLKDVMKEPCIAADGYTYDRRAIEEWMENHRTSPVTNSPLQNVNLLPNHTLYAAIVEWRNRNQ
What is the function of this protein?
Functions as an E3 ubiquitin ligase.
What are the official names of this protein?
Putative U-box domain-containing protein 53, Plant U-box protein 53.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: PRSA_CLOBL
Sequence: MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPNMQQVLSQIKTQYGEEFEKTEQGKEVIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEADKKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLKDQIVIEKVINEVTKDVKVEDKDAQKYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDTGSKEKGGLLGDISYSDSNYDPTFMKAAIALKSGEISNPVHTQWGYHIIKINSKKEYPVKKFDSVKEDIKKQLKQEKQQEAYTKKIEEWKKASKIKTYEKNLL
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: KDSB_PSYA2
Sequence: MSSALMPVRTHIVIPARLKSTRLPNKPLLTIHGKPMILWVAEKAQLADFADDMCIATDDESVAKVCAEAGFDVVMTRSDHASGTDRLAEVAAIKGWAAHDIVVNMQGDEPLIPPLLLEQVKTLLVQDAESVMATLCEPIEDYNTFIHPSVVKVVSQNTNNQQRAIYFSRAPIPCDRDVVLSDEDNTQAPKNAYRHLGLYAYRVSLLQQFVHWSQTPLEILESLEQLRVLENGGHIAIAKAACPLPAGVDTQEDLDRLNAMSLTAFQDD
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRP5_ARATH
Sequence: MASKSLFLVALLVGSFAFTSFASVANRKLKSGLEDQKTFFHHPGGGLGGGGGIGGGSGLGGGGGFGGGGGLGGGAGGGGGLGGGAGGGAGGGFGGGAGSGGGLGGGGGAGGGFGGGAGGGSGGGFGGGAGAGGGLGGGGGAGGGGGFGGGGGSGIGGGFGGGAGAGGGFGGGHH
What is the function of this protein?
Involved in organ growth by promoting cell elongation processes.
What are the official names of this protein?
Glycine-rich protein 5, AtGRP-5, AtGRP5.
What are the subcellular locations of this protein?
Vacuole.
Protein: MNMA_TRIV2
Sequence: MKKVVVGLSGGVDSSTAAAILHNQGYEVIGLTLWLMKGKGQCCSEGMIDAAYICEQLGIPHEVVDMRDVFQTHIVDYLVTGYGAGITPLPCSQCNKTVKFGPMVQYAREQLGCDRIATGHYARISYDEASGRYQLLRAVDRNKDQSYFLYDLSQDLLAASLFPLGEMEKADTRRIATEHGLKTADKPESQDLCLVESNGSMRAFLDKYIAPKKGDIVDTAGKILGQHDGVHHYTIGQRKGLGIAAPEPLYVVELDAVNNKVVVGDRTKATQEECTVSRVNWVSIPEPSTPIRAAVQIRYRSAPEPVTVIPLENSRVRLVFDEPQFSITPGQAAVWYDGDKVLGGGIIEQFSN
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPB_RANTE
Sequence: MFTLKKSLLLLFFLGTINLSLCEEERNAEEERRDEPDERDVQVEKRLLPIVGNLLKSLLGK
What is the function of this protein?
Amphipathic alpha-helical antimicrobial peptide with potent activity against Gram-positive bacteria, weak activity against Gram-negative bacteria, and moderate activity against fungi (PubMed:9022710, PubMed:27351824, PubMed:30718667).  Mainly acts by causing membrane permeabilization, but is unable to forme pore-like openings (Probable).  Is also able to penetrate eukaryotic cells (keratinocytes), and kill intracellular S. aureus (both wild-type and MRSA) without injuring host cells (PubMed:24514087).  Shows inhibitory effect on biofilm formation of Gram-positive bacteria, but not of Gram-negative bacteria (PubMed:27351824, PubMed:28443279).  Shows antiviral activity against herpes simplex virus 1 (HSV-1) by disrupting the viral envelope (PubMed:29483113).  Also displays anti-leishmania activity by damaging parasite membrane (PubMed:15513914, PubMed:25668079).  Does not show hemolytic activity (PubMed:9022710, PubMed:15513914, PubMed:28443279).  Acts synergistically with temporin-L that improves temporin-1Tb activity by preventing its self-association in lipopolysaccharides (LPS) (PubMed:16867990, PubMed:21586570).  In vitro, promotes cell migration and wound healing (PubMed:24514087).
What are the official names of this protein?
Temporin-1Tb, TB, Temporin-B.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Target cell, target cell cytoplasm. Note=Contact and insertion into membrane begin at the N-terminus.
Protein: TOP1_HELPJ
Sequence: MKHLIIVESPAKAKTIKNFLDKNYEVVASKGHVRDLSKFALGIKIDETGFTPNYVVDKDHKELVKQIIELSKKASITYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNVLKTPRKIDMFKVNAQQARRLLDRIVGFKLSSLIASKITKGLSAGRVQSAALKLVIDREKEIRPFKPLTYFTLDALFEPHLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYIISSIIKKSKKSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARAKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSIILEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQSVVVACEKGEFKASGRKLLFDGHYKILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKYIKQTENANDEAKQELCEKCGGEMVQKFSRNGAFLACNNYPECKNTKSLKNTPNAKETIEGVKCPECGGDIALKRSKKGSFYGCNNYPKCNFLSNHKPINKRCEKCHYLMSERIYRKKKAHECIQCKERVFLEEDNG
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: RLME_PSEAE
Sequence: MARSKTSQRWLKEHFDDPYVKMAQRDGYRSRASYKLLEIQEKDRILRPGMTVVDLGAAPGGWSQVTSRVIGDRGRLIASDILEMDSIPDVTFIQGDFTEDAVFARILEAIGDHPVDLVISDMAPNMSGVRAADQPRAMYLCELALDLAGRVLRPGGDFLIKIFQGEGFDQYHKQAREMFDKVQMRKPLSSRDRSREQYLLARGFRGE
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.