PharMolix/UniProtQA huggingface dataset:
Protein: LEPA_CAUVC
Sequence: MRTRMTSTPLDKIRNFSIVAHIDHGKSTLSDRLIQTTGGLTAREMSAQVLDNMDIEKERGITIKAQTVRLTYKAADGETYILNLMDTPGHVDFAYEVSRSLAACEGSILVVDASQGVEAQTLANVYQAIDNNHEIVPVLNKVDLPAADVDRVKAQIEDVIGLDASDAVECSAKTGVGIPEVLEAIVTRLPPPKGDPNAPLKALLVDAWYDAYLGVVVLVRIFDGSLKAGQQVRMMQTGATHRIDKVGVFTPKATDVEYLGPGEVGFFTASIKEVADAAVGDTITDEKKPTAEALKGFKEVVPVVFCGLFPVDAADFEDLRAAVGKLRLNDASFTYEMESSAALGFGFRCGFLGLLHLEIIQERLSREFDLDLIATAPSVVYKIKLRNGDEIELHNPADLPDVMQIEEIAEPWIKATIFTPDDYLGGVIKLCQDRRGMQRELSYVGSRAMVVYDLPLNEVVFDFYDRLKSISKGYASFDYQLEDYRAGDLVKMSILVNSEPVDALSMLVHRSRAESRGRGMCEKMKELIPQHMFVIPIQAAIGGRIIARETVRALRKDVTAKCYGGDASRKKKLLEKQKEGKKRMRQFGKVEIPQEAFIAALKMDED
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: UPPP_PORGI
Sequence: MTILQAIVLAIVEGLTEFLPVSSTGHMIIAEGIMGVESTSFVRAFTVMIQFGAILSVLVLYRKRFFCFPVAPRALGQGKGKEFMSRFDLYWKLLIALVPAVILGFLFEDWVDRMLGSVWVVAVVLFLGGIFMLFVDKLFASSDRGEITYPKAFVIGLFQCLAIFLPGLSRSMATIVGGQQQKLSRKAAAEFSFFLAVPTMLGATLLKAYKLYKEGGIEIFREHMTVLLVGNIVAFIVALAAIKFFIGFLTRYGFKAFGYYRILVGGLLIVLMLSGVSLAV
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL15_PSEA8
Sequence: MQLNDLRSAPGARREKHRPGRGIGSGLGKTGGRGHKGLTSRSGGKVAPGFEGGQQPLHRRLPKFGFVSLKAMDRAEVRTSELAKVEGDVVSLQTLKDANLINQHVQRVKVMLSGEVGRAVTLKGIAATKGARAAIEAAGGKFED
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL30_SALTI
Sequence: MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAVRGMVNAVSFMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: THIG_CHLCH
Sequence: MDSLHIGSYSFSSRLILGTGKFSNSKVMLEAIRASGSQLVTVALRRFNREQAEDDLFGPLSALEAVTLMPNTSGASTAAEAIRAAHIARQLSGSPFIKVEIHPNPQHLMPDPIETFEAAKVLVNDGFLVMPYIAADPVLAKRLEEIGCASVMPLGSAIGSGQGLSTFEMLKIIIRESTIPVIVDAGLRSPSEAAHAMEMGCSAVLVNSAIAAAGNPPAMAEAFSEAVIAGRKAFQAGLMEQSGEAVATSPLTFLGA
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_METFK
Sequence: MTTPLMHSSIKSLKLINQGKVRDIYDIDDRHMLLVASDRLSAFDVILPTPIKDKGAILTQIANFWFEKLKHIVPNHLTGIDPNTVVKDPAEQAQLGPRALVVKKLKPLPIEAIVRGYLAGSGWKEYQASQSVCGIPLPAGLQEAAQLPEPLFTPSSKAEVGDHDENITLEKCAQLIGPELADKVARVSVQLYKEAAAYALGRGIIIADTKFEFGLDEAGELYLIDEVLTPDSSRFWPQDQYQVGSNPPSFDKQYVRDWLESTGWNKTPPGPALPDEVAARTADKYREAFERLTGKPF
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: MEP_ASPTN
Sequence: MRLLSLAGAMALPLCVLAHPTHRTRGIARRGIDLTPYRLPGNAEYTSSRTSAMRSLLFERADGEDYVETAKKVLQSVHPDATFRVIDDHYVGDNGVAHVHLLQTAHGIDIDNANFNVNIDKNGKVLSYGNSFFSGKIPDSDPLTKRSFSDPVEALKAAATGLGIPLTADDVTSEGLDGTTSYTFKGTKGALSDPTADLVYLAKPDNTLALTWRVETDMNSNWLLTYVDAETAETIHGVVDYISDATYQVYPWGLNDPTEGSRQILEDPWDSKASEFTWIGDGKAKYKTTRGNNGIAQSNPDGGDDYLNNHRPESSSLKFVYPYSPNATSPSSYIDASITQLFYTANTYHDLLYTLGFNEKAGNFEANNNGAGGKGNDFVILNAQDGSGTNNAMFGSPPDGRPGRMYMFIWTESNPPRDGSMEAGIVIHEYTHGLSSRLTGGPANARCVDGEESGGMGEGWGDFMATAVRLKSGDTRQTDYTMGAWAANDPKGIRDYPYSTSMTKNPLTYAHLNNVTEVHEGGTIWASMLYEVMWNLIDKHGKNDAPKPDLKDGVPTDGKYLSMKLVMDGMALQPCNPSFIQARDAILDADVALTKSGNQCEIWKGFAKRGLGERAALKNGIRVDSFDVPKGVC
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.
What are the official names of this protein?
Extracellular metalloproteinase mep, Elastinolytic metalloproteinase mep, Fungalysin mep.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYP_STAAS
Sequence: MKQSKVFIPTMRDVPSEAEAQSHRLLLKSGLIKQSTSGIYSYLPLATRVLNNITAIVRQEMERIDSVEILMPALQQAELWEESGRWGAYGPELMRLQDRHGRQFALGPTHEELVTSIVRNELKSYKQLPMTLFQIQSKFRDEKRPRFGLLRGREFIMKDAYSFHADEASLDQTYQDMYQAYSRIFERVGINARPVVADSGAIGGSHTHEFMALSAIGEDTIVYSKESDYAANIEKAEVVYEPNHKYSTVQPLEKIETPNVKTAQELADFLGRPVDEIVKTMIFKVDGEYIMVLVRGHHEINDIKLKSYFGTDNIELATQDEIVNLVGANPGSLGPVIDKEIKIYADNFVQDLNNLVVGANEDGYHLINVNVGRDFNVDEYGDFRFILEGEKLSDGSGVAHFAEGIEVGQVFKLGTKYSESMNATFLDNQGKAQPLIMGCYGIGISRTLSAIVEQNHDDNGIVWPKSVTPFDLHLISINPKKDDQRELADALYAEFNTKFDVLYDDRQERAGVKFNDADLIGLPLRIVVGKRASEGIVEVKERLTGDSEEVHIDDLMTVITNKYDNLK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RWDD3_PONAB
Sequence: MAEPVQEELSALAAIFCGPHEWEVLSRSETDGTVFRIHTKAEGFMDADIPLESVFHLPVNYPSCLPGISINSEQLTRAQCVTVKEKLLEQAESLLSEPMVHELVLWIQQNLRHILNQPETGSGYEKCTFSTSTTVDDGLWITLLHLDHMRAKTKYVKTVEKWASDLRLTGRLMFMGKIILILLQGDRNNLKEYLILQKTSKVDVDSSGKKCKEKMISVLFETKVQTEHKRFLAFEVKEYSALDELQKEFETAGLKKLFSEFVLALVK
What is the function of this protein?
Enhancer of SUMO conjugation.  Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1.  Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity.  Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia.  Has no effect on ubiquitination (By similarity).
What are the official names of this protein?
RWD domain-containing protein 3.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Colocalizes with UBC9/UBE2I in nuclear spots.
Protein: SPED_YERPB
Sequence: MSKLKLHGFNNLTKSLSFCIYDICYAKTADDRDGYIAYIDEQYNANRLTEILSETCSIIGANILNIARQDYDPQGASVTILVSEEPVDPRDVDTSEHPGPLPSAVVAHLDKSHICVHTYPESHPEAGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTMDYRVRGFTRDINGVKHFIDHKINSIQNFMSDDMKSLYHMMDVNVYQENIFHTKMMLKDFDLKHYLFNAKPEELSAEEKEQITRLLYKEMQEIYYGRNVPEV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: BUD22_YEAST
Sequence: MPSESSVSIYKLDQLEYQYHYLTKSLQKFEPRYPKTAKLYNCIGKKNKKKIEKLLNSLELKTLDKELDESYSKLLNNKIHYYETHLSKCIKEQIQKISKKNSSKVKDAQKNKSPSIDIEKMLATQLSLDDLALFMTRFRLIKILHQRIKQKSKKIEGDTNNKTWLNNNDYSGYINDKTSKWNPSNIWNEVITKLPSCEKLNALIGQSKIVQNLTESFDLSICLIFGFDVSAMKAKKYGAREKTANANQTHSNIDYDTDDGNEKNAIDSKSNAIGAQTQSNKETTSDNEDLLIKEYEGMLGSSGDEGEGGGYLNPNINYNEVTDEEPSEASSDEDDSDERFSDSEENEPRRKKPKLHNLPELMAGYYSGNDTEEESDEDNKNVKGKKKKRDTAEDRTAREQMSNEPKRKNRRGQRARRKIWEKKYGSQAKHVQRELEKEMEDRKQRQIEYEARVAKREAKAASLEASRSREREDRRTETNNKKEKESASTGEEHPSWIAKRLAEEKLQKAKFEGKKIKFD
What is the function of this protein?
Involved in positioning the proximal bud pole signal.
What are the official names of this protein?
Bud site selection protein 22.
What is the protein family that this protein belongs to?
Belongs to the BUD22 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RBSD_SALA4
Sequence: MKKGTVLNSEISSVISRLGHTDTLVVCDAGLPIPNSTARIDIALTQGVPSFMQVVDVVTREMQVEAAILATEIKQQNPQLHETLLTHLEQLQQHQGNTIKISYTTHEQFKKLTADSQAVIRSGECSPYANVILCAGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSB_COLP3
Sequence: MRVFTAILLILLVLLQYRLWFGKNSVPDYLVLKENVVRQQSANEKLQQRNKLLFADTDDLKLGLEAIEERARNELGMIKENETFFRLIPKENSTRNVNN
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: HSLU_COXBN
Sequence: MTMTPREIVAELDKFIIGQNDAKRAVAIALRNRWRRMQLGEELRREIFPKNILMIGPTGVGKTEIARRLSDLAGAPFLKIEATKFTEVGYVGRDVESIIRDLVDVAVKMTREKAIRQVKSLAEEAAEERVLDALIPPARGGFQGEPTAEEKPTEKKESATRQLFRKKLRNGGLDDKEIEVEVSAHPSFEIMGPPGMEEMVSQLQGIMSSMSSRRSKSRRLKVKDALRILGEEEAAKLVDEDQIKSTALASVEQNGIVFIDEIDKIVKRDGAVGADVSREGVQRDLLPLVEGSTVFTKYGMVKTDHILFIASGAFHIAKPSDLVPELQGRFPIRVELKALTADDFVRILTEPKASLTEQYTELLKTENFGLSFTKDGIKRLAEIAYQVNDRSENIGARRLHTIMERLLEEVSFEATDKQGESITIDADYVNKQLKKLAEDEDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSP4_ARATH
Sequence: MNCLQNLPRCSVSPLLGFGCIQRDHSSSSSSLKMLISPPIKANDPKSRLVLHAVSESKSSSEMSGVAKDEEKSDEYSQDMTQAMGAVLTYRHELGMNYNFIRPDLIVGSCLQTPEDVDKLRKIGVKTIFCLQQDPDLEYFGVDISSIQAYAKKYSDIQHIRCEIRDFDAFDLRMRLPAVVGTLYKAVKRNGGVTYVHCTAGMGRAPAVALTYMFWVQGYKLMEAHKLLMSKRSCFPKLDAIRNATIDILTGLKRKTVTLTLKDKGFSRVEISGLDIGWGQRIPLTLDKGTGFWILKRELPEGQFEYKYIIDGEWTHNEAEPFIGPNKDGHTNNYAKVVDDPTSVDGTTRERLSSEDPELLEEERSKLIQFLETCSEAEV
What is the function of this protein?
Starch granule-associated phosphoglucan phosphatase involved in the control of starch accumulation.  Acts as major regulator of the initial steps of starch degradation at the granule surface.  Functions during the day by dephosphorylating the night-accumulated phospho-oligosaccharides.  Can release phosphate from both the C6 and the C3 positions, but dephosphorylates preferentially the C6 position (PubMed:20018599, PubMed:26231210).
What are the official names of this protein?
Phosphoglucan phosphatase DSP4, chloroplastic, AtPTPKIS1, Dual specificity protein phosphatase 4, Protein STARCH-EXCESS 4, AtSEX4.
What are the subcellular locations of this protein?
Plastid, chloroplast. Note=Associated with starch granule.
Protein: EFG_FERNB
Sequence: MEEIKALYVDLNKLRNIGIMAHIDAGKTTTTERILYFTGRKHQIGSVDDGTATMDWMVQEKERGITITSAATTCLWKEHRINIIDTPGHVDFTIEVERSLRVLDGAVAVFDATAGVEPQSETVWRQADKYNVPRIAFMNKMDKTGADFEMAVQTMVERLGAHPIPVQLPMGAESDFAGVIDLIEMKAIRWLNPEGTEMVVEEIPTQWKDKADEAREDMIEKIAEVDDEIMEMYLEGEEPSIEQIHAALRRITIAGLGTPVFCGSAKMNLGIQPLLDGIVRYLPSPLDLPPVKGFDKAGNEIQVQPTENAPFVAYAFKIQTDPYVGKLTFLRVYSGKLEKGSYVINTTKGVKERVSRLIFLHADKREDVEYVRAGDIVGVIGMKSTITGDTVCEENTYVILEKMEFPEPVISIAIEPETKDDETKLSKALQSLLDEDPSLRAYVDQETGETILSGMGELHLEIIVDRLKREFNVNVRVGKPQVAYRETITKDVKIEGKYIRQSGGRGQYGHVVVQFEPLGLDKTFEFVDKTVGGVIPKQYIPAIEEGIREAMQVGVLAGYPVVGIKATLLDGSYHEVDSSEMAFKIAASMAFKEAMEKGNPVLLEPIMKVEVTTPEDYMGNIIADLNSRRAHIDALENRGHLRVVKALVPLSEMFGYATTLRSLSQGRANYTMVLSHYEKVPEKVAEKILKG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTP_DROME
Sequence: MLNNLGANVLGPKDCDLPKAALTALHAGVNSFGQLPVGPNLADLGGGAGGGGSSGGVPVGGGVARLHISGGLCDNSNALNGGNGSSGNGNGNNNNGNGNNNNSMQQQDQKRHRTRFTPAQLNELERCFSKTHYPDIFMREEIAMRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRTPGALLPSHGLPPFGANITNIAMGDGLCGTGMFGGDRWSVGVNPMTAGFGQLNQSSPLSSSLNSGLNSGINMGSALGAGSYQHYGLNALGDSMMYQHSVGGVSCGPSGSPSATTPPNMNSCSSVTPPPLSAQPNSSQNELNGEPMPLHQQQQQQTHQHQQQQTHQHHPMAPPTPTQQQQQLPQSMQSPSDGANDTLHSIAALRRRASELNAIPSYLQMAPHNYEHYNSNSNSVY
What is the function of this protein?
May be involved in the development of the central nervous system.
What are the official names of this protein?
Homeobox protein orthopedia.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PLS6_PHYSA
Sequence: MAFLKKSLFLVLFLGLVSLSICEEEKRETEEEEHDQEEDDKSEEKRFLSLIPHIVSGVASIAKHLG
What is the function of this protein?
Antimicrobial peptide with high activity against Gram-positive bacteria, low activity against Gram-negative bacteria, and moderate activity against fungi (By similarity).  Acts by causing bacterial membrane disruption inducing leakage of the intracellular content followed by cell death (By similarity).  It adopts an alpha-helical amphipathic structure in membrane environments (By similarity).  Also shows highly potent antiparasitic activity against Leishmania species (By similarity).  Shows moderate hemolytic activity on human erythrocytes (By similarity).  Is also active on human monocytes (By similarity).
What are the official names of this protein?
Phylloseptin-S6, PLS-S6.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the target.
Protein: CLPX_GLUOX
Sequence: MSNKSGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREEHKTHLVKSRDGVPTPKEICKVLDDYVIGQFEAKRALSVAVHNHYKRLAHAAKSSDIEIAKSNILLIGPTGSGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVENIILKLLQSADYNVDRAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLMEGTVASVPPQGGRKHPQQEFLQVDTTNMLFICGGAFAVWTRSFRRVARDRASASVQMCVLMTSVVLGAILQSVEPEDLLKFGLIPEFIGRLPVIAALNDLDESALIQILSKPKNALIKQYGRLFEMEGVKLTFTEDALAAIAKRAIERKTGARGLRSILESILLGTMFDLPGLEGVEEVVINRDVAENKAQPVYVYGKGKSEPAEQSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: SET2_DEBHA
Sequence: MSDMEELDVKAKQYTPQLFLESEDKTDEARSTFNELQECTYSSKSTGSSGQHEHMTCDCYEDWDSDKQQNMACGEDSDCINRVTSVECSNKFCTCGNDCQNQRFQKKQYANVTVIQTELKGYGLRANEDISESSFIYEYIGEVIDEESFRKRMIDYDTKKLIHFYFMMLKKDSFIDATMKGSLARFCNHSCNPNAYVDKWVVGEKLRMGIFSKRNIQKGEEITFDYNVDRYGAQSQPCYCGEPNCIKWMGGKTQTDAALLLPDGISEALGVTHKQERQWLKENKHLRSKQQSDESIINEAFVKSIEVSALTESDVSKVMGALMRVQDLNITQKLIERIYLTSDDSINSSIIRVHGYKTLSQTIKAFKDEDKELISKILIILAKWPKVTRNKISSSQIEDVVKDINTNSNDDNLKKLSSDLLAEWGKLQMAYRIPKNIGNDKESNSPALYGRNARSRSRSRSPDRGKSAEPQHVETDEALPDGWQTAFDPNTQTNYYYHAELGISKWERPIKEVPKGPKGPKALPVSEPIQRPNSNSNGRSYNEEELTRREEERLKREKEEQFKEIQQKERLLQELILQSQKELEEKKSFEEKMKLEKLEKEKERQALKRKKLKKSKSSIPPAPPVPIDGQWTKTFAKHVPNFLKKYEAEIGRDNIKGCAKELVKTLVAKEMKKNPDTKPPKELDNAKLKKIKEYSKMFMDKFLIKYRSKHDKKRSHNEENGGTKRVKPDVE
What is the function of this protein?
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3.  Involved in transcription elongation as well as in transcription repression.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-36 specific, SET domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MSHB_STRSW
Sequence: MTDLPSSGPRPGEPLSRVGHRLLLVHAHPDDESINNGATMAKYAAEGARVTLVTCTLGEEGEVIPPSLAHLAPDRDDTLGPYRVDELAGAMKELGVTDHRFLGGAGRYRDSGMMGVEQNERPGAFWSADVDEAAAHLVRVVREVRPQVLVTYDPDGGYGHPDHIQAHRVAMRAAGLAADPAFRPDLGEPWDIAKVYWNRVPRGVVLEGFERLRRDLAEPGRVPFRQAASVTDVPGVVDDHLVTTEIDGTGFAAAKAAAMRAHATQIEVAEPYFALSNALAQPLLSTEYYELVRGRREGGSRESDLFEGIPGISFEERQNGTAL
What is the function of this protein?
Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
What are the official names of this protein?
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, GlcNAc-Ins deacetylase, N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase.
What is the protein family that this protein belongs to?
Belongs to the MshB deacetylase family.
Protein: YCF15_CUCSA
Sequence: MTHYIKKFPLMKDVNPLENQKYACRMKWLLLSVTITNHWFN
What are the official names of this protein?
Putative uncharacterized protein ycf15.
What is the protein family that this protein belongs to?
Belongs to the ycf15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MDTL_ECOL6
Sequence: MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLNFPWQSLFWTMAIMGVAVLMLSLFILKETRPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA
What is the function of this protein?
Confers resistance to chloramphenicol.
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AACUM_ASPA1
Sequence: MGEGGYRQINKTLNVCAFDDYLVTQQSRLPKLLDIEQLSPRVLRVLGQNAGKFTLQGTNTYIVGTGQHRLIIDTAQGYREWADLIDVTLSNRSISLSHVFLTHWHGDHTGGVPDLIRMYPHLADGIYKNSPEQGQHPIEEGQIFKVEGATIRAVHGPGHSHDHMCFVLEEENAMFTGDNVLGHGTSAVEQLGLYMDTLRKLQAQGCRTGYPAHGAVIPDLNLKIATELAQKTRREKQCLAALGRIRKERPTGQLASVTVGELIDVVHGTRVNEEVRKMALEPFMEEVLRKLAEDGKVAFRVRKGVKTWFALT
What is the function of this protein?
Atrochrysone carboxyl ACP thioesterase; part of the gene cluster that mediates the biosynthesis of the tetrahydroxanthone dimer secalonic acid D (PubMed:30996871, PubMed:33891392).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase AacuL (Probable).  The atrochrysone carboxyl ACP thioesterase AacuM then breaks the thioester bond and releases the atrochrysone carboxylic acid from AacuL (Probable).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase AacuI, and oxidized by the anthrone oxygenase AacuG to yield emodin (Probable).  Emodin is then reduced to emodin hydroquinone by a yet unidentified oxidoreductase (Probable).  A-ring reduction by the short chain dehydrogenase AacuN, dehydration by the scytalone dehydratase-like protein AacuK and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:33891392).  Baeyer-Villiger oxidation by the Baeyer-Villiger monooxygenase (BVMO) AacuH then yields monodictyphenone (PubMed:33891392).  Monodictyphenone is transformed into compounds with the tetrahydroxanthone skeleton via methylesterification by the methyltransferase AacuQ, followed by the action of the flavin-dependent monooxygenase AacuC, the isomerase AacuP, and the short chain dehydrogenase/reductase AacuF or AacuD (PubMed:33891392).  AacuF and AacuD should accept the same compound as a substrate but perform the ketoreduction with a different stereoselectivity, thus yielding blennolides B and A, respectively (PubMed:33891392).  In the final step of the biosynthesis, the cytochrome P450 monooxygenase AacuE accepts blennolide B and/or blennolide A to conduct the dimerization reaction to furnish the tetrahydroxanthone dimers, secalonic acids D, B, and F (PubMed:33891392).
What are the official names of this protein?
Atrochrysone carboxyl ACP thioesterase AacuM, ACTE AacuM, Secalonic acid biosynthesis cluster protein M.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.