PharMolix/UniProtQA huggingface dataset:
Protein: VANB_ACIAD
Sequence: MINMDVIIHKIHQLTPSIRAFELISANGSDLPAFDAGSHIDVHLKNGLTRQYSLSNCCSEQHRYVIGVLHDENSRGGSRCIHQDYREGDHLNIGTPRNLFEIHSKTQKAVLFAGGIGITPILSMAYRLKHQQIPFELHYFVRSHEMIAFYGNLTEHFPEQIHFHIQNQSETQCEMSKVLEEVAPDRHLYVCGPAGFMQFVMDSAQQAGWSDEQLHQEHFVAPQIDQSQNEAFTIEVLGSDRKIEVSAHQTATQALLEHGFDVPVSCEQGICGTCITRVVSGTPDHRDVFMTDEEHALNDQFTPCCSRAKSKILVIDLA
What are the official names of this protein?
Vanillate O-demethylase oxidoreductase, Vanillate degradation ferredoxin-like protein.
What is the protein family that this protein belongs to?
Belongs to the PDR/VanB family.
Protein: ARSB_FELCA
Sequence: MGRRGAASLPRGPSPRRPLLPGVLPLLLRLLLLPSRPGAGAGADRPPHLVFVLADDLGWNDVSFHGSNIRTPHLDELAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIHTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCALIDSLNVTRCALDFRDGEQVATGYKNMYSTNIFTERATALITSHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHYYAGMVSLMDEAVGNVTAALKSHGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGIRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGSTKGTKPLDGFDVWKTISEGSPSPRKELLHNIDPNFVDISPCPGKSLAPAKDDSSHPAYLAFNTSLHAAIRHGNWKLLTGYPGCGCWFPPPSPYNDSAIPSSDPPTKTLWPFDIDQDPEERHDLSRDYPHIVEQLLSRLQFYHKHSVPVHFPAQDPRCDPKGTGAWGPWV
What is the function of this protein?
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity).  Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity).  In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
What are the official names of this protein?
Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Lysosome. Cell surface.
Protein: ZNRF3_HUMAN
Sequence: MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPGA
What is the function of this protein?
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6.  Acts on both canonical and non-canonical Wnt signaling pathway.  Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959).  Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase ZNRF3, RING finger protein 203, RING-type E3 ubiquitin transferase ZNRF3, Zinc/RING finger protein 3.
What is the protein family that this protein belongs to?
Belongs to the ZNRF3 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: GSA_CHLT3
Sequence: MLNLKTSAALFERAKKVIPGGVNSPVRAFNSVGGTPVFVTKGEGARMIDVDGNSYIDYVGSWGPFILGHSHPRVIEAIERTMKAHGTSFGAPTELEIELAELIIKVVPSVEMVRMVNSGTEATMSAIRLARGYTKREKIIKFEGCYHGHGDSFLIKAGSGALTLGAPSSPGVTEGTAKDTLNATYNDIESVRALVDSNKGNVAAIIIEAVGGNMGVVPSKKEFLVALRELCDKEGIVLIFDEVMTGFRVALGGAQEVYGITPDLTTMGKIIGGGLPVGAYGGKKEIMEHVSPVGTVYQAGTLSGNPLAMSAGLATIKILAEENPYPELEKKAVIIEEGFKSNLEKLGLNLCQTRVGSMSCLFFTDKEVVDFETANSSDTAKFATYFNSMLESGIYLACSQFEAMFISTMHTEEDLQKTIEANYNALKLAYGK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_ACIC1
Sequence: MEPFTTHTGRAVPLRRSNVDTDQIIPAVYLKRVSRTGFADGLFAAWRQDPGFVLNRPEFAGADILVAGPDFGTGSSREHAVWALQDYGFRVVISPRFGDIFRNNALKGGLLAVVLPESDVEALWDVVESDPATPVTVDLVTREVRYADVVRGFDIDDYTRWRLMEGLDDIGLTLRHADAIDAFEARRPAWKPTTRAS
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RIMO_SULSY
Sequence: MKNLKINFISLGCPKNLVDTEVLIGKLNQENISFTANPEEADVILINTCGFIEPAKEESIETILEAVKLKQNSNKKIIVTGCLVERYKQELEKEIPEVDYFIDLKNQSQIPVLFDIKPKENTKRIISTPKHTAYLKISEGCDHTCSFCAIPNIRGKHRSKPIEALVEEAKYLANLGVKELNIVSQDTSYYGYDLYGKPMLFELLQHLEKIDGIKWIRLYYLYPSTVDEDFFKFIKGSEKILHYIEMPIQHSEDKILKDMMRGYRKKKLYQILEWKEKYTPDMTIRSSVIVGYPTETEEDFENMKNFIQEAQFDWLGVFVYSHEEGTPAYQKHKDKIPKKEKIRRLNEISALQENITEQKNKSLIGKELDIIIDGFSEEWETLPIGRSYRSAFEIDGAVYVETTEPVNVGDIIKVRIKDTIDKYDVVGEAE
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED10_PONAB
Sequence: MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 10, Mediator complex subunit 10.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GAL1_THENE
Sequence: MRVKAPGRINIIGEHTDYNDGYVLPFAVNRFVFLTIEDSGKFVFHSENMNETVEMEKIEKLNRWTDYISGVIKAFEKRGYKVSPVKISVSSNLPMGAGLSSSAALEMATAYAISEHFGFHLPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKDHAIFLDTMTLEYEYVPLKLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLRVLGKRSFREVTKEDLKKLPDVLKKRAQHVLEENERVLKSVQALKEGDFETLGRLLFSSHESLRDLYEVSCEQTDFIVDFLKGREGILGARMVGGGFGGGVIVLSKKGAFEKIKEELKNAYRDRFKIELTFHEIESADGVQKI
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REI1_CHATD
Sequence: MATIAGSRAPTEVPSHPYTCNTCQVAFRNSELQRGHMRSDWHRYNLKRRVASLPPISSEVFTEKVLQARAATTAQADKAGFEKTCEVCQKTYYSENSFRNHLSSTKHKSKAAAAARRPANNKVDDDVSSMSFSLGEPARADSVVDSEAEEEFSEVVEGIKNASIHDTASPIKRPSAPQPAVEEQSKTDAQMEETPTTTPKPEALTPSATTCVFCNYESPTPQLNASHMERIHGMFIPEKQYLVDLEGLLKHLWEKVFRYNECLTCGKMKVNVFAIQTHMRDKSHYHIPYTTEEEQLEIGEFYDFRSTYSDGDWETEEEDKGEEDGGVRLGAKRESKVVDENGDEVMEDEEGWETDSDASSLDTDDLHAVPAEGHYHQYERLGKHPHHSRENKKAHREADGIHAPSKRTHAVYYDEYELHLPSGKSVGHRSLARYYRQNLYHYPTPEERAERLAIEAAERENRMDVDGEEPERGRTRTRALVPRDIKGLGVTTMSDPRVRGIVQKGKKEEWKNRDSKWWMHSQVAIKEKAKHPSTYLR
What is the function of this protein?
Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit.  Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity).
What are the official names of this protein?
Cytoplasmic 60S subunit biogenesis factor REI1 homolog, pre-60S factor REI1 homolog.
What is the protein family that this protein belongs to?
Belongs to the REI1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGOD_ECOBW
Sequence: MKITKITTYRLPPRWMFLKIETDEGVVGWGEPVIEGRARTVEAAVHELGDYLIGQDPSRINDLWQVMYRAGFYRGGPILMSAIAGIDQALWDIKGKVLNAPVWQLMGGLVRDKIKAYSWVGGDRPADVIDGIKTLREIGFDTFKLNGCEELGLIDNSRAVDAAVNTVAQIREAFGNQIEFGLDFHGRVSAPMAKVLIKELEPYRPLFIEEPVLAEQAEYYPKLAAQTHIPLAAGERMFSRFDFKRVLEAGGISILQPDLSHAGGITECYKIAGMAEAYDVTLAPHCPLGPIALAACLHIDFVSYNAVLQEQSMGIHYNKGAELLDFVKNKEDFSMVGGFFKPLTKPGLGVEIDEAKVIEFSKNAPDWRNPLWRHEDNSVAEW
What is the function of this protein?
Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
What are the official names of this protein?
D-galactonate dehydratase, GalD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: WWTR1_MOUSE
Sequence: MNPSSVPHPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGGPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKVMNQPLNHVNLHPSITSTSVPQRSMAVSQPNLAMNHQHQQVVATSLSPQNHPTQNQPTGLMSVPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMETETMAPVNTPAMSTDMRSVTNSSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNMDEMDTGENSGQTPMTVNPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL
What is the function of this protein?
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213).  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity).  WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (By similarity).  In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:21145499).  Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (By similarity).  Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (By similarity).
What are the official names of this protein?
WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (PubMed:11118213). When phosphorylated is retained in the cytoplasm by YWHAZ (PubMed:11118213). Can be retained in the nucleus by MED15 (By similarity). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (PubMed:21145499).
Protein: BIP_CANGA
Sequence: MNAIKRLLPVSLFLYALFVVLLPFQARAKDDVENYGTVIGIDLGTTYSCVAVMKNGKTEILANEQGNRITPSYVAFTDDERLIGDAAKNQIAANPTNTIFDIKRLIGLKFNDRSVQRDIKHLPFKVVDKDGKPVVQVKVKGEDRVFTPEEISGMILGKMKQIAEDYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKSDKEHQIIVYDLGGGTFDVSLLSIENGVFEVQATSGDTHLGGEDFDYKIVRQLIKTFKKKHGIDVSDNEKALAKLKREAEKAKRALSSQMSTRIEIDSFVDGIDLSETLTRAKFEELNLDLFKKTLKPVEKVLEDAGLEKKDIDDFVLVGGSTRIPKVQQLLESFFNGKKASKGINPDEAVAYGAAVQAGVLSGEEGVEDIVLLDVNALTLGIETTGGVMTPLIKRNTAIPTKKSQIFSTAVDNQPTVQIKVYEGERAMSKDNNLLGKFELTGIPPAPRGIPQIEVTFALDANGILKVSATDKGTGKSESITITNDKGRLTQDEIDRMVEEAEKFASEDAVLRTKIEARNKLENYAHSIKNQVEGDLAEKLEEEDKETLLDAANDTLEWLEDNFDSATTEEFEEKFEALSKTAYPITSKLYGGADGSAPVYDDDEDEDDDTDYFDDEL
What is the function of this protein?
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.  Is required for secretory polypeptide translocation.  May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.
What are the official names of this protein?
Endoplasmic reticulum chaperone BiP, Immunoglobulin heavy chain-binding protein homolog, BiP.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: HRD11_ARATH
Sequence: MAGLINKIGDALHIGGGNKEGEHKKEEEHKKHVDEHKSGEHKEGIVDKIKDKIHGGEGKSHDGEGKSHDGEKKKKKDKKEKKHHDDGHHSSSSDSDSD
What is the function of this protein?
Intrinsically disordered and metal-binding protein.  Binds to the divalent cations cobalt, nickel, copper and zinc, but not to magnesium, calcium, manganese or cadmium (Ref. 8).  Binding to metal ions decreases disordered state, decreases susceptibility to trypsin and promotes self-association.  Can reduce the formation of reactive oxygen species (ROS) in a copper-ascorbate in vitro system (PubMed:23382551).
What are the official names of this protein?
Dehydrin HIRD11, Histidine-rich dehydrin of 11 kDa, AtHIRD11, Protein SRC1 homolog.
What is the protein family that this protein belongs to?
Belongs to the KS-type dehydrin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CITD_CROS8
Sequence: MKIVKEALAGTAESSDLMVKIAPAAGELEIEIYSDVIKQFGDQIRRVVKETLAAMEVYEGLVIIEDKGALDCVIRARLQSAVLRACEAQPLRWEALK
What is the function of this protein?
Covalent carrier of the coenzyme of citrate lyase.
What are the official names of this protein?
Citrate lyase acyl carrier protein, Citrate lyase gamma chain.
What is the protein family that this protein belongs to?
Belongs to the CitD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGA33_CANAL
Sequence: MRGIILLSFVLTSCLAADAVPAAADAAAVTTTTPAGAAAAAATTATTAKANTAATTNTAAAAAAAADTLTTKGTTTGTAKTTGVTTGTAKTTATTAVTSDTAVAANPATMNPSELSIYSLTVTMNQAQLQNFLATHSSGAATAGATGTSVASGASGASLEDSTTTTAAAAAGGNGAATIDDTTKGLTFVTSRTLKPSSSATSQGSAQASGSGSNASQANAAGVYSTNSVLVFVSICIGFIGGSLGI
What are the official names of this protein?
Predicted GPI-anchored protein 33.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: CH10_PECAS
Sequence: MNIRPLHDRVIVKRKEVESKSAGGIVLTGSAAGKSTRGEVLAIGHGRILENGEVKPLDVKVGDIVIFNDGYGVKAEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICP55_YEAST
Sequence: MLHRINPVRFSMQSCQRYFSKLVSPLEQHKSNTFTNRVRIPIEAGQPLHETRPFLIKSGELTPGISALEYYERRIRLAETLPPKSCVILAGNDIQFASGAVFYPFQQENDLFYLSGWNEPNSVMILEKPTDSLSDTIFHMLVPPKDAFAEKWEGFRSGVYGVQEIFNADESASINDLSKYLPKIINRNDFIYFDMLSTSNPSSSNFKHIKSLLDGSGNSNRSLNSIANKTIKPISKRIAEFRKIKSPQELRIMRRAGQISGRSFNQAFAKRFRNERTLDSFLHYKFISGGCDKDAYIPVVATGSNSLCIHYTRNDDVMFDDEMVLVDAAGSLGGYCADISRTWPNSGKFTDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQELKNLGIDKVSGWNVEKLYPHYIGHNLGLDVHDVPKVSRYEPLKVGQVITIEPGLYIPNEESFPSYFRNVGIRIEDDIAIGEDTYTNLTVEAVKEIDDLENVMQNGLSTKFEEDQVAPL
What is the function of this protein?
Aminopeptidase which cleaves preprotein intermediates that carry destabilizing N-ter amino acid residues after the mitochondrial processing peptidase (MPP) cleavage site and is thus critical for stabilization of the mitochondrial proteome.
What are the official names of this protein?
Intermediate cleaving peptidase 55, Intermediate cleaving peptidase of 55 kDa.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Has the same dual localization (mitochondrion and nucleus) as one of its substrate, NFS1.
Protein: RL10_PARL1
Sequence: MDRAEKSELVTHLNGVFANAGVVVVAHYSGLTVNQMSDLRSRMAKAGASFKVTKNRLAKLALDGTPMTEIGDLFAGPTAIAYSQDPVAAPKVAIEFAKENQKLVILGGAMGQTVLDAKAVKQLADLPSLDELRAKIVGMIQTPATRIAGVLQAPGGQLARVLNAYATKSEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RL32_MYCSS
Sequence: MAVPKRRMSRSNTRSRRAQWKAKPTELVGVTVAGQQHKVPRRLLKAARLGLIDLDRR
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: CRED_ASPFC
Sequence: MALSFFGGGGASHLKYFDIRLDEDYIVFRGGEQEAASAQLSGKLLLCLSEPLSVKHVRLNLTGISRVCWHLPSSSATGGRKSWREKVFYEKSWTFRDAGKSKTEILAAGNYEFPFHVILEGSMPESVEGLSDTYVTYRFKAEIGRKYAKDIVVRKPLRIIRTLDSSALELSHAMSVENIWPNKIEYSISTPTKAVIFGTSIRVDFKLIPLLKGLKIGQIVSQLIESHDLTLNPEDPDSVRNTYKNTRTIVNDEHELDEEGNLEIIDEAAEGYQFSRFLDLPKTLTRCLQDTDTRGIKIRHKLKFRVQLLNPDGHISELRATLPVSIFISPNLAIDDNNNLVDQTPQSAQRAVNDLAQQAPPLYGEHQFDQLYSEVDPSGYRTPGPGSGPGTPFGTLSRNLSAENLASMNALTNTDISASALHSRLSNLHASRFSNPSPSDADGHTDAEYRRLGVSTDSFGPSSGSNSQSPASPELSRRPSDEGYHDHDYIPSGMATPFHPQFAEVESLSRVPSYSTAVRSSVGPCDSELPDYQAVVAEDTAMPTLQSPQQAHIRSVGRGVSTGHTGIDVHHLRSGFFNSRTSAHHDDDDRRLRLVQARARV
What is the function of this protein?
Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB.  May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability (By similarity).
What are the official names of this protein?
Probable HECT-type ubiquitin ligase-interacting protein creD, Carbon catabolite repressor D.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
Protein: LMBD1_REOVJ
Sequence: MKRIPRKTRGKSSGKGNDSTERADDGSAQLRDKQSSKVTQNVKEPGTTLKEQYKTRPSLQTVQKATENAELPMQTNDEGAVDKKGNTKGDKTNEHVEAEVNAADATKRQAKDTDKQKAQVTYNDTGINNANELSRSGNVDNEGGDNQKPMTTRIAEATSAIISKHPARVGLPPTASSGHGYQCHVCSAVLFSPLDLDAHVASHGLHGNMTLTSSEIQRHITEFISSWQNHPIVQVSADVENKKTAQLLHADTPRLVTWDAGLCTSFKIVPIVPAQVPQDVLAYTFFTSSYAIQSPFPEAAVSRIVVHTRWASNVDFDRDSSVIMAPPTENNIHLFKQLLNNETLSVRGANPLMFRANVLHMLLEFVLDNLYINKHTGFSQDHTPFTEGANLRSLPGPDAEKWYAIMYPTRMGTPNVSKICNFVASCVRNRVGRFDRAQMMNGAMSEWVDVFETSDALTVSIRGRWMARLARMNINPTEIEWALTECAHGYVTVTSPYAPSVNRLMPYRVSNAERQISQIIRIMNIGNNATVIQPVLQDISVLLQRISPLQIDPTIISNTMSTVSESTTQTLSPASSILGKLRPSNSDFSSFRVALAGWLYNGVVTTVIDDSSYPKDGGSVTSLENLWDFFILALALPLTTDPCAPVKAFMTLANMMVGFETIPMDNQIYTQSRRASAFSTPHTWPRCFMNIQLISPIDAPILRQWAEIIHRYWPNPSQIRFGAPNVFGSANLFTPPEVLLLPIDHQPANVTTPTLDFTNELTNWRARVCELMKNLVDNQRYQPGWTQSLVSSMRGTLDKLKLIKSMTPMYLQQLAPVELAVIAPMLPFPPFQVPYVRLDRDRVPTMVGVTRQSRDTITQPALSLSTTNTTVGVPLALDARAITVALLSGKYPSDLVTNVWYADAIYPMYADTEVFSNLQRDMITCEAVQTLITLVAQISETQYPVDRYLDWIPSLRASAATAATFAEWVNTSMKTAFDLSDMLLEPLLSGDPRMSQLAIQYQQYNGRTFNVIPEMPGSVVTDCVQLTAEVFNHEYNLFGIARGDIIIGRVQSTHLWSPLAPPPDLVFDRDTPGVHVFGRDCRISFGMNGAAPMIRDETGMMVPFEGNWIFPLALWQMNTRYFNQQFDAWIKTGELRIRIEMGAYPYMLHYYDPRQYANAWNLTSAWLEEISPTSIPSVPFMVPISSDHDISSAPAVQYIISTEYNDRSLFCTNSSSPQTIAGPDKHIPVERYNILTNPDAPPTQIQLPEVVDLYNVVTRYAYETPPITAVVMGVP
What is the function of this protein?
Inner capsid (core) component.  Displays NTPase, RNA 5'-triphosphatase (RTPase) and RNA helicase activities and probably participates in transcription of the viral genome.  Helicase activity might be involved in unwinding or reannealing dsRNA during RNA synthesis.  RTPase enzymatic activity represents the first step in RNA capping, which yields a 5'-diphosphorylated plus-strand RNA (By similarity).
What are the official names of this protein?
Inner capsid protein lambda-1, Lambda1, ATP-dependent DNA helicase lambda-1, Lambda1(Hel).
What is the protein family that this protein belongs to?
Belongs to the orthoreovirus lambda-1 protein family.
What are the subcellular locations of this protein?
Virion. Note=Found in the inner capsid (120 copies).
Protein: PDXH_RHOPT
Sequence: MSDPTIRPQSELTPGDFTAAENPFALFAEWLAEANKSEPNDPNAMALATVDPDGLPDVRMVLMKGYDEHGFVFYSHIASQKGRELAANPKAALLFHWKSLRRQIRIRGTVTPVTDTEADAYFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVTARHLIGDVPRPPGWSGWRITPSRIEFWHDRPFRLHDRIEFRRDTPDHPWTKTRLYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: METK_GEOSW
Sequence: MSKKRRLFTSESVTEGHPDKICDQISDAILDAILEKDPNARVACETSVTTGLVLVSGEITTSTYVDIPKIVRDTVREIGYTRAKYGFDADTCAVLTSIDEQSPDIAMGVDKALEAREGQMTDEEIEAIGAGDQGLMFGFACNETKELMPLPISLAHRLARRLSEVRKEAILPYLRPDGKTQVTVEYDENGKPVRIDTIVVSAQHHPEITQEQIERDIKEHVIKPIVPAELIDENTKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYVAKNIVASGLADKCEVQLAYAIGVARPVSISIDTFGTGKVSEDILIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDIDLPWERTDKAETLKEQALALAKQ
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WTF1_MAIZE
Sequence: MDAKLLLPFPFAPAAATRSPKSLFLGAPLPPPPRPPPFPLRLRPRPAAVVAQAAVKRRKEAPFDTVIQRDKKLKLVLKLRNILVAQPDRVMSLRELGRFRRDLGLTRKRRLIALLRRFPGVFDVVEEGVYSLRFRLTPAAERLYLDELRLRNESEGLAVAKLRKLLMMSQEKRILIEKVAHLKHDLGLPPEFRDTVCLRYPQYFRVVRMDRGPALELTHWDPELAVSAAELAEEESRAREAEERNLIIDRPLKFNRVRLPKGLKLTRGEARRIARFKEMPYISPYADFSHLRSGSDEKEKHACGVVHEILSLTVEKRTLVDHLTHFREEFRFSQSLRGMIIRHPDMFYVSFKGDRDSVFLREAYKDSQLVEKNQLVLLKEKMRALVAVPRFPRRAAVGTGEEAEGMNGSLQSRDQVSDEEYDDEDEGLSDMEDLISELSGGKSDADYEWGDGWFGENDDSPPDFGDDEVKVAMKIADGSANGSAPVPVFPDGRPRERW
What is the function of this protein?
RNA-binding protein involved in the chloroplastic group II intron splicing.  Binds specific group II introns and promotes their splicing.  Functions in the context of a heterodimer with the ribonuclease III domain-containing protein RNC1.
What are the official names of this protein?
Protein WHAT'S THIS FACTOR 1, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast.