PharMolix/UniProtQA huggingface dataset:
Protein: ULAR_ECO81
Sequence: MTEAQRHQILLEMLAQLGFVTVEKVVERLGISPATARRDINKLDESGKLKKVRNGAEAITQQRPRWTPMNLHQAQNHDEKVRIAKAASQLVNPGESVVINCGSTAFLLGREMCGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQSITLSPQGSENSLYAGHWMFTSGKGLTAEGLYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNANPEILQQLEAQGVSILRV
What is the function of this protein?
Represses ulaG and the ulaABCDEF operon.
What are the official names of this protein?
HTH-type transcriptional regulator UlaR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNB_SCHJY
Sequence: MAAAKEKSDVLVNNEIHNCAELICSICRQLYKSGWVTGTGGGITIRTGDHIVIAPSGVQKEKLEVKDMFVMSLTTRDYLHTPKQNSKPSQCTPLFLSVYTSRDAYACIHTHSQEAVLLSNLFAQKTHFESSGFDVQRYIPRGSKKNGFYKFEDTIRIPFINNTAHESDLQSNLQKAINENPYTCAVIVRNHGIYAWGDSWEDAKMNTEAVEYLFHVFLRDYRIKHSKNCRFF
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_BPHA1
Sequence: MSATSEYPVQRWFGMEVLDHSQGAIDWSRMRSGAPLLAQHDRWSTKGQIGVVEEAWLDDDRRMRVRVRFSKSKEAEEIWRDVVDGIRRNVSCGYLPQEMVLEKREGDLEHFRVTRWQPFEISIVSVAADPTVGIGRSTDQTTSTITIRGSEMDEQENTTTTAQQPGKSVNGEHQEPTTRTFAEPKDGALEKERQRSADILALGERFSQRDLAMQAVTQGYSVDSFRRQLLDAQAPQPIDTNPGDNQRDLPQFNHQRPGQNVEKLGITERDMSQYSLLRAINAMATGDYKDAGFEREVSNAIADASGTEARGLFMPHEALFGGMLRQQEKKTPSKGGILVDTDMRTDMYTEILKNRTVLGALGATVLSGLQGDVDIPKQLSEGNFYWLDEDGEAPQSDIDFGTIGLSPKTISGAIAITRRLRKQASMSIENLVRNELLSGVAVTTDKGYLYGTGEDNQPLGLMYQTGIPGLTYADKFGWDEAVDMETQVGQANVSANGMGYLTSVGQRGAGKKTFVAAGTGERLWHNNEVNGYRAMASNQVNADTWVFGDWAQVLIALWGVVDLKVDQATKAASDGLILRVFQDVDVNARRKEAFSIARKSVA
What is the function of this protein?
Assembles to form an icosahedral capsid.
What are the official names of this protein?
Major capsid protein, Gene product 5, gp5, Major head protein.
What is the protein family that this protein belongs to?
Belongs to the HK97 phage major capsid protein family.
What are the subcellular locations of this protein?
Virion. Note=Forms the icosahedral capsid shell.
Protein: YBEY_SHESR
Sequence: MSLDLALDVQYATASDYLPSEEQFSLWVKTAIGNSMEQAELTIRIVDARESQMLNSTYRGKDKPTNVLSFPFEAPPEIELPLLGDLVICAAVVENEAREQDKILEAHWAHMVVHGCLHLLGYDHIEDEEAEEMESLETQLIESLGFTDPYKEQ
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSA_XYLFT
Sequence: MGIRIQELRKQFEDFTALAGIDLDIRQGELLALLGPSGSGKTTLLRIIAGLEHADAGRVLFGDEDATTMSVQARRVGFVFQHYALFKHMSVYENVAFGLRVRRGKARWPESQISARVFELLSLVQLDGLEQRYPMQLSGGQRQRVALARALAIEPRVLLLDEPFGALDAQVRRDLRRWLREIHDRTGLTTVFVTHDQEEALELADRVAILNQGGIEQVASPDEVYNRPSSPFVYSFVGAVNRLPGCVGADGLEVAGIVLSCPPQLSGWGAVDLYVRPEDLVLDAQEGWSAIVLWSQRSGPRMRVRARLEHSAHEVEIELSSATDEYVEGQKLRLIPRHYGVFFSESGS
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL23_BORPD
Sequence: MNAERLMQVILAPVVTEKATFVAEKNQQIAFRVVADATKPEIKAAVELLFKVQVESVQVLNRKGKVKRFGRFVGRRRSERKAYVALKEGQEIDFAEVK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: TIR_ECOCB
Sequence: MPIGNLGHNPNVNNSIPPAPPLPSQTDGAGGRGQLINSTGPLGSRALFTPVRNSMADSGDNRASDVPGLPVNPMRLAASEITLNDGFEVLHDHGPLDTLNRQIGSSVFRVETQEDGKHIAVGQRNGVETSVVLSDQEYARLQSIDPEGKDKFVFTGGRGGAGHAMVTVASDITEARQRILELLEPKGTGESKGAGESKGVGELRESNSGAENTTETQTSTSTSSLRSDPKLWLALGTVATGLIGLAATGIVQALALTPEPDSPTTTDPDAAASATETATRDQLTKEAFQNPDNQKVNIDELGNAIPSGVLKDDVVANIEEQAKAAGEEAKQQAIENNAQAQKKYDEQQAKRQEELKVSSGAGYGLSGALILGGGIGVAVTAALHRKNQPVEQTTTTTTTTTSARTVENKPANNTPAQGNVDTPGSEDTMESRRSSMASTSSTFFDTSSIGTVQNPYADVKTSLHDSQVPTSNSNTSVQNMGNTDSVVYSTIQHPPRDTTDNGARLLGNPSAGIQSTYARLALSGGLRHDMGGLTGGSNSAVNTSNNPPAPGSHRFV
What is the function of this protein?
Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection.  The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface.  Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion (By similarity).
What are the official names of this protein?
Translocated intimin receptor Tir, Secreted effector protein Tir.
What is the protein family that this protein belongs to?
Belongs to the Tir receptor family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Secreted via the type III secretion system (TTSS). Released into the host cytoplasm via TTSS and then independently inserts into the plasma membrane from a cytoplasmic location. In host cells, localizes to the tip of the actin pedestal (By similarity).
Protein: ZMAT2_MOUSE
Sequence: MASGSGTKNLDFRRKWDKDEYEKLAEKRLTEEREKKDGKPVQPVKRELLRHRDYKVDLESKLGKTIVITKTTPQSEMGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMRVERSTLDQVKKRFEVNKKKMEEKQKDYDFEERMKELREEEEKAKAYKKEKQKEKKRRAEEDLTFEEDDEMAAVMGFSGFGSTKKSY
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the spliceosome.
What are the official names of this protein?
Zinc finger matrin-type protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH60_AGARV
Sequence: MAKEIKYGSEARAALGAGVDKLANTVRVTLGPKGRNVVLDKSYGAPLITNDGVTIAKEVELEDAFENMGAQLVKEVATKTNDVAGDGTTTATVLTQAMVQEGMKNLEAGANPIVLRRGMKKATDKAVEALKDMSQKVKGKEQIAKVAAISAGDEEVGNLVADAMEKVTNDGVITIEESKTMQTELDLVEGMQFDRGYLSAYMCTDMDKMEAVLDDPYILITDKKISNIQDILPLLEKIVQAGARLLIIAEDVEGEALTTLIVNKLRGTFNVVAVKAPGYGDRRKAMLEDIAILTGGQVISSDLGLELKDTTIDMLGRAKSVKVQKENTVIVDGAGDKDAIAGRVSQIRGQIDETTSEFDKEKLQERLAKMAGGVAVIRVGAATETEMKEAKLRMEDALNATRAAVEEGIIAGGGSAYIHASKKVAELVDTLEGDEKTGAKVILKALEAPLYYIAANAGLEGAVIINKVKESAPGTGFNAATEEYVDMVDNGILDPVKVTRSALQNATSVASTLLTTESAVATIKEDTPAMPAGAGAGMGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCR5_THEGE
Sequence: MDYQVSSPTYDIDYYTSEPCQKINVKQIAGRLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
What is the function of this protein?
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.  May play a role in the control of granulocytic lineage proliferation or differentiation.  Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
What are the official names of this protein?
C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CURA_ECOLI
Sequence: MGQQKQRNRRWVLASRPHGAPVPENFRLEEDDVATPGEGQVLLRTVYLSLDPYMRGRMSDEPSYSPPVDIGGVMVGGTVSRVVESNHPDYQSGDWVLGYSGWQDYDISSGDDLVKLGDHPQNPSWSLGVLGMPGFTAYMGLLDIGQPKEGETLVVAAATGPVGATVGQIGKLKGCRVVGVAGGAEKCRHATEVLGFDVCLDHHADDFAEQLAKACPKGIDIYYENVGGKVFDAVLPLLNTSARIPVCGLVSSYNATELPPGPDRLPLLMATVLKKRIRLQGFIIAQDYGHRIHEFQREMGQWVKEDKIHYREEITDGLENAPQTFIGLLKGKNFGKVVIRVAGDD
What is the function of this protein?
Catalyzes the metal-independent reduction of curcumin to dihydrocurcumin (DHC) as an intermediate product, followed by further reduction to tetrahydrocurcumin (THC) as an end product.  It also acts on 3-octene-2-one, 3-hepten-2-one, resveratrol, and trans-2-octenal.
What are the official names of this protein?
NADPH-dependent curcumin reductase, NADPH-dependent curcumin/dihydrocurcumin reductase.
What is the protein family that this protein belongs to?
Belongs to the NADP-dependent oxidoreductase L4BD family.
Protein: EIF3L_CRYNJ
Sequence: MADPSAFYEPEEDELLSQLAIPVQNYQPLSEGDEYRRLQQLEQHAYAQQTAMAQEQEMEQLAVLELIPEDVKRFLVMFHQAILENDLPTITSMYESGWNKLTQAHYLNNEWPEAELIAPLVGNDQVFLTLYRELYFRHVYARLQPTIDDRFQSYENICELFNYLLNSEGPVPLDLPIQWLWDMLDEFVYQFTSFSHWRSSPKAKTEEELEMLAESPNIWSSYSVLNVLYSLVQKSQINEQLKAERAGKSVEEVTEVAGEYGSKPLYKNLGYFSLICLLHVHVLLGDPTLALQTMENVDLGNAAFLTRITACHVTTYYHVGCAYMALGRWPDAIKTFVSVLIFFIRMKQYHTRSYQYGSIAKTCERMYALLAICTTLSPGPSDENIMTIVKEHYGDQLAILQRGGPEALEAFKDLYLQACPKYLNVNPPPYEDASALEAWLANPPADATQRHLELFLSDVQAVQGVNGMRNLLKLYTSIDAAKLAAFSVSGEEEGEEEVLQQLMVLKSASSTYGRGQAETTLLDGERKVTNNLDFTIDGTMVHVEETTSHRRYAGFFIRNAEHAQRALTSIKSAPLPVRKPASSSAPAPATTAAPISKSGESAAPAPAEAPAAPEKKAGTWVPKSRQARIAA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit L, eIF3l.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1249_NEIM0
Sequence: MNLSNHFLVAMPDMEDAFFSQSVVYICKHDEDGALGIAINKPSPITMDMIFSATGKNIPMRMQHDSVMMGGPVQVDRGYVVHTPIGNWQSSIGVSDNIALTSSRDVIENISREGAVDKALISIGYSSWGKGQLERELADNAWLTVPADEHILFDIPYEHRYAAAFAKLGIDPLALHGKAGHA
What are the official names of this protein?
UPF0301 protein NMCC_1249.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: NDK_YERP3
Sequence: MALERTFSIIKPNAVANNNIGAIYARFESAGFNIIAAKMLHLTKEQAEGFYAEHKGRPFFDGLVEFMTSGPIMVQVLEGENAVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSDAVESAQREIAYFFAADEIFPRS
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2SAF_SPIOL
Sequence: EDSLSDWERVYLPIDPGVVL
What is the function of this protein?
Essential for photosystem II (PSII) biogenesis; required for assembly of an early intermediate in PSII assembly that includes D2 (psbD) and cytochrome b559.
What are the official names of this protein?
Photosystem II stability/assembly factor HCF136, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the Ycf48 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen. Note=Restricted to the stromal lamelae. Translocation into the thylakoid lumen occurs via the Tat pathway.
Protein: LEUC_NITOC
Sequence: MAGKTLYDKLWNSHVVRTNPGGTALLYIDRHLVHEVTSPQAFEGLRLAGRKPWRKGANLAVPDHNVPTTDRSQGIQDPISRIQVEALDRNCQELGLTEFRMDDPRQGIVHIVGPEQGATLPGMTVVCGDSHTATHGAFGALAFGIGTSEVEHVLATQCLLQKKSKNMLIQVSGKLAPGVYSKDLILAIIARIGTAGGTGYTIEFAGETIRALSMEGRMTLCNMAIEAGARAGLVAVDETTIDYLKGRPFAPSPHSWGQAVNAWQMLQSDPDASFDRVVTIDAAALKPQVSWGTSPEMVASIDGRVPDPRQESDPTKRGGMERALEYMGLAANTPISEIRPDIIFIGSCTNARIEDLREAAKVVAGHKVAGNIKQALVVPGSGLVKRQAETEGLDQIFKEAGFEWREPGCSMCLAMNADRLEPEERCASTSNRNFEGRQGQGGRTHLVSPAMAAAAAVAGHFTDVSTLNH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: ATPF_DESHY
Sequence: MNPIHFDLTLVVQVLSFLLLVYILRRFAWNPLINMMEERRSQIEANIANAEKERLQAEQIKREYQEEMRKARQEAQEVIAKATKLSEQRAAEILAAAHGEAEKIKQSALADIERERDRAIAQVQAQVADLSVAVAEKIIRKNLDVRGQEDMIEQFIQEVGELPC
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: DHKA_DICDI
Sequence: MELKTFKDLNDDIIGDTSPVINTGDQPNPLRTQQQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHHIPQQLYQKQQQQQHSHSYGNHSFIHNVSPTSPSYDINNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNKNNYNNNYYYSPIENSNISKSLEESVLNQFPHNFNLNSSNNNYLNNSSSLHNINQSVNSLSNNNNNQTNQQPINNNNNNNNNNNNNNSNNSNNSNNNNNGNNNNNITDSPTKSKRHSTYETNIGSHQRRKSIQSLIANSAIHSFSKLKNKPLSSSTPSTVNTCGAVNNNSNNNNNNNNNSTGSLGAIPMDRSFDGNINTITEESTGGNNSPRSNCGSNCGSNGGIPLSPRNLSSLNSGVNVSPRNIHLNNLNNNSSNLPPLSPRHINFHINVSNLNNNNNNNINPNNNPNNSNNSNNNVSPRNNNHNISPRGSNISPRSNNGGSTTISPRNISNNNNIINNINNNNILTPPRNSPRLENVNPTNSPRLLATSLNSTLPIVSSLTSSNNNNQSNNNTNPSINNNNGRNGHCIQTISEEILGNKPVVYNNGNNNNNNNTNNSTTSNNNITTNNNNNNNNNINNNVLSTPRKRTKGNHSKTNSLQDFETSSMNGGDDSISGAGSGGSLRRRNKDDNDENDGNSNNTNSNNSNNNNNNNNNSSNNNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNYHNGATMMMSHNHQSIGMSSSPKKNNFKPFSRNCSLMGMGRRAWAIILGLFIVGSSISILATLVLRYSEENSIADDFARVARDRFTMLRIEFNNRLYITQTLSLLLSVFPSTSEDQFVPFSKLWSDNAEGLEGIMWAPRVSNLDRYTWEIEHSVKIREIVTNPNNSSDMRDVPAAAASDYYPILFSEPQSSNDHFKGYNIYSDMWRRPSLNKTRDTGEKVSVASPYINKLANVPKNSRSNVLLYIYQAVYTYGKVLSTVEDRRHEVIGFASCRFFISRMVSASLQRLTEEDSLDLYVFDLDSTPIGELIYYRASNAGNDDGSSPTNIMNGKMLEDRSDMIYYNTMNVGGRNWMIALRPSRKFTNKHYTFYPYAIGGVCMLLSALVSFWFAVNTKHNIKLSATNEDLHKEIYNRKLAEKALAESQERLELAMEGSEDAVWDWKVNTGELHISSRWFQILKAHDTSYQSRTLYEELKSSSTNNLNFKGDSKNGGSNNGTFNLFKNGKVDSSSPQSITNVNTTNGGGGGELRKSNSGYLYNDELFSPIILEEMVSSPNTHQLAIWNMKFLAELIHPDDKQKFISEIKKTITRETSIMEIECRMRKKYGGYLYIIMRGKVVSNETSFKDNSLRMAGTLRDMTSRKDMQRLILEKEAAEEANKAKSAFVATVSHEVRTPLSGVIGVSDLLLETNLSEEQRDYVQTIQKSSQALLTIINDILDYSKLESRQLKMETLPFSIIETCQAVIHMLSVAANDDVDILLRVPPNVPRIIFGDAMRMRQVLLNLLSNAIKFTSRGHVLTDISVDDSIPPTNTEEEIIHLCITIEDTGIGIPQSLFDSIFEPFSQADNSTTRKYGGTGLGLSITKRLIEEVMGGTIQVSSIVGQGSKFKCIIPFLLPNTSPSDLNLISPSSLPKPFINRSPKSTYSFTDKKNSVPSTPIPSGDILINKVCLLICRDTVTELVFKEQLEWLGMIVKQVPRNVIDSIKNTILNNNNNNNNNNNNNNNNSNNSSSIISPSSLDYSDENEHLDLVLIDLEILTEHLKIPSNVPIIFITPTKFNISKHNGILNKWITKSPNQRVELIRRPAITDKLIPIISKCIKSQVQFTSGSSQLQSQQANLQQQLLHQQLCNNGQTLNNNYNSGGIGGGGGGGGSNTMNGSSGNLSNNNNFGQTPLSSGLVLLVHTGRTPPLFNNNGNSIIPPLELAVDHHGNQQQQLYQQQQQQQNNSSGNFQQFYQQQNNNSNNSFTPTLPNENSNNSIMNNSLNNNNTTPSNVTPTLFTSSPLDLQGRDTPVLQPPAYRKKALIVEDNELNRKVLAQLFKKIDWTISFAENGREALKEITGERCFDIVFMDCQMPVLDGFQTTKIIRSKERENNWKRMNIVALSAGSSSSFVQDCLDSGMDSFMGKPITLATLKDALAKWGGYNN
What is the function of this protein?
Acts as a receptor histidine kinase for the cytokinin SDF-2 in a signal transduction pathway that regulates prestalk gene expression and controls terminal differentiation of prespore cells.  Binding of SDF-2 to this protein inhibits phosphorelay and induces rapid sporulation.  This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain.
What are the official names of this protein?
Hybrid signal transduction histidine kinase A.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: STE20_CANGA
Sequence: MSNANQKENVPSLGLPRTHGTLNVNALKATDILKHKGKLNEVNSDQSTTNENDEVQEEAVFLDDPVHFTRVSSSSELSAALSVNTTEQEQDEEKGTEHAELEPAEEDTVEVDTIRNNGDKTYSTIRESASDFETTNNTLIEISKNSSTYSSTEFLNNNNNGISNSNRATIDSESKLRMNKLREGSSTSLSNDSNGFNGMISSNQASTVLSTPSQKPSSTTNTITKANNGGSTRAQKEKHTSPKLPSTVTAPSSHRKSADLSKTNKLPSTTAKRTPKQAVTSSSPKEPAKRKSSTSKMKGMFSSLVQNMKRNSSDNRKSASSLSSVSSSSSSTLKISTPYNPKHIYHVGVDARTGEYTGLPEEWERLLASSGISRKEQQQNMQAVIDIVNFYQDVADHTGEEKVIKTFDPKKQNPLVRDSLSKYEQVDDNRTSYASGGTPTLEQNGFHTSSTPRSRTSLTSPTAGYSMISTPPMATQEKYIPTRPAPKPPGQQTPSSNASLTPKMQNATMSPIKENISSPVTKSEVDDELLLSKKNASLPKLPSDDSSSHKKSATDSAPTSVETDTETVKVPPIPKTTPTVPAKASRRSNEKKKEERERNKKLLYAKLTEICSPGDPKSKYRDLIKIGQGASGGVYIAHDTESEDSVAIKQMNLEKQPKKELILNEILVMRESKHSNIVNFIDSYLAKGDLWIVMEYMEGGSLTDVVTHCLLSEGQIGAVCRETLKGLQFLHSKGVLHRDIKSDNILLSLKGNIKLTDFGFCAQINENNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPEALSDTLTKFLDWCLKVDPSERATATELLDDPFITEIAEDNSSLSPLVKLARIKKLEEQEEDAGTDETEPETTPDTTI
What is the function of this protein?
MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle.  Phosphorylates histone H2B to form H2BS10ph (By similarity).  Involved in cell wall integrity, hypertonic stress adaptation and virulence.
What are the official names of this protein?
Serine/threonine-protein kinase STE20.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RLMH_LEGPH
Sequence: MLKITIITLGNKMPDWVNSGVNEYAKRFHDGIQIKLIEIPLLRRNKSSDLARILEKESALTKDALPANARLIALDMLGKSFSSEELALRLTQLQQISSHLCFIIGGPEGLSNEILTLCDERWSLSKLTLPHPLVRIILLESLYRAWSIINNHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOLD1_BOVIN
Sequence: MAKCLLLLLLVVLSSLLGLPQALECFQCNRVNASGVCETGGSTCQTQGSQQCFLRRIFENGTLSYGHQGCSQLCIPMKLFNPSVIVEYKCCHDSPLCNKF
What is the function of this protein?
Binds specifically to type I collagen.
What are the official names of this protein?
Secreted protein of Ly-6 domain 1, Protein BOP1.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted from the basolateral region of the cell near the extracellular matrix.
Protein: TCEA2_RAT
Sequence: MGKEEEIARIARRLDKMVTRKNAEGAMDLLRELKNMPITLHLLQSTRVGMSVNALRKQSSDEELIALAKSLIKSWKKLLDVSDGKSRDQGRGTPLPTSSSKDASGTTDLSCKKPDPPRTSSTPRITTFPQVPITCDAVRNKCREMLTLALQTDHDHVAVGVSCEHLSSQIEECIFLDVGNTDMKYKNRVRSRISNLKDAKNPGLRRNVLCGAITPQQIAVMTSEEMASDELKEIRKAMTKEAIREHQMARTGGTQTDLFTCNKCRKKNCTYTQVQTRSSDEPMTTYVVCNECGNRWKFC
What is the function of this protein?
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
What are the official names of this protein?
Transcription elongation factor A protein 2, Protein S-II-T1, Testis-specific S-II, Transcription elongation factor S-II protein 2, Transcription elongation factor TFIIS.l.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IMMF_BPPH1
Sequence: MLDGKKLGALIKDKRKEKHLKQTEMAKALGMSRTYLSDIENGRYLPSTKTLSRIAILINLDLNVLKMTEIQVVEEGGYDRAAGTCRRQAL
What are the official names of this protein?
ImmF control region 10 kDa protein.
Protein: LEXA_RHOPT
Sequence: MLTRKQFELLKFINERLKEAGVPPSFDEMKDALDLRSKSGIHRLITALEERGFIRRLPNRARAIEVIKLPDTGGMPGNSRRGFTPSVIEGNLGKVRPPSPTPAEDDHDRGSVAVPVMGRIAAGTPIEALQSRSHTISVPADMLGSGEHYALEVRGDSMVEAGILDGDMALIQKNDVADTGDIVVALIDEEEATLKRFRRRGASIALEPANAAYEVRILPPNRVRIQGKLIGLYRKY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: LLDD_YERPS
Sequence: MIISASTDYRAAAQRKLPPFLFHYIDGGAYNEQTLRRNTADLADIALRQRVLKNMSELSLETQLFGETQAMPVVLGPVGLSGMYARRGEVQAARAADKKGIPFTLSTLSVCPIEEVAPAIARPMWFQLYVLKDRGFMRNALTRAQAAGVKTLVFTVDMPVPGARYRDAHSGMSGPNAAARRLLQAIAHPQWAWDVGLNGKPHDLGNISAYLGKPTTLEDYMGWIATNFDPSISWKDLEWVREFWQGPMIIKGILDPEDAKDAVKFGADGIVVSNHGGRQLDGVLSTARALPAIADAVKGDITILADSGIRTGLDVVRMIALGADSVLLGRAFVYALATAGEAGVINLLTLIEQEMRVAMTLTGAKRIADINRDSLAVSERG
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.