PharMolix/UniProtQA huggingface dataset:
Protein: RUVA_FRATF
Sequence: MISFIKGVLIEKDPTALLIDVNGIGYEVFVPMTTFYTLGDIDSQVSLYTHFVVREDAQQLYGFKSKVDKKVFQELIKVNGIGARTAIAILSGMDSKTLLHCIENKDYALLATVPGIGKKTAERLVVEIYDKLLKMANEIYAQTSGTTTTSQDSQAQQAPTSVVLANSIFNESVDALLALGYKQKDAEKMARSAMGDATTAAEVIRKALQGSIKSKG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: O13C3_HUMAN
Sequence: MIVQLICTVCFLAVNTFHVRSSFDFLKADDMGEINQTLVSEFLLLGLSGYPKIEIVYFALILVMYLVILIGNGVLIIASIFDSHFHTPMYFFLGNLSFLDICYTSSSVPSTLVSLISKKRNISFSGCAVQMFFGFAMGSTECLLLGMMAFDRYVAICNPLRYPIILSKVAYVLMASVSWLSGGINSAVQTLLAMRLPFCGNNIINHFACEILAVLKLACADISLNIITMVISNMAFLVLPLMVIFFSYMFILYTILQMNSATGRRKAFSTCSAHLTVVIIFYGTIFFMYAKPKSQDLIGEEKLQALDKLISLFYGVVTPMLNPILYSLRNKDVKAAVKYLLNKKPIH
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 13C3, Olfactory receptor OR9-8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COX2_PRATU
Sequence: MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAAILILIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKYFENWSASMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HPR1_YEAST
Sequence: MSNTEELIQNSIGFLQKTFKALPVSFDSIRHEPLPSSMLHASVLNFEWEPLEKNISAIHDRDSLIDIILKRFIIDSMTNAIEDEEENNLEKGLLNSCIGLDFVYNSRFNRSNPASWGNTFFELFSTIIDLLNSPSTFLKFWPYAESRIEWFKMNTSVEPVSLGESNLISYKQPLYEKLRHWNDILAKLENNDILNTVKHYNMKYKLENFLSELLPINEESNFNRSASISALQESDNEWNRSARERESNRSSDVIFAADYNFVFYHLIICPIEFAFSDLEYKNDVDRSLSPLLDAILEIEENFYSKIKMNNRTRYSLEEALNTEYYANYDVMTPKLPVYMKHSNAMKMDRNEFWANLQNIKESDDYTLRPTIMDISLSNTTCLYKQLTQEDDDYYRKQFILQLCFTTNLIRNLISSDETRNFYKSCYLRENPLSDIDFENLDEVNKKRGLNLCSYICDNRVLKFYKIKDPDFYRVIRKLMSSDEKFTTAKIDGFKEFQNFRISKEKIPPPAFDETFKKFTFIKMGNKLINNVWKIPTGLDKIEQEVKKPEGVYEAAQAKWESKISSETSGGEAKDEIIRQWQTLRFLRSRYLFDFDKVNEKTGVDGLFEEPRKVEALDDSFKEKLLYKINQEHRKKLQDAREYKIGKERKKRALEEEASFPEREQKIKSQRINSASQTEGDELKSEQTQPKGEISEENTKIKSSEVSSQDPDSGVAGEFAPQNTTAQLENPKTEDNNAATSNISNGSSTQDMK
What is the function of this protein?
Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export.  The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription.  THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase.  It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
What are the official names of this protein?
THO complex subunit HPR1, Hyperrecombination protein 1.
Protein: ATPA_YERP3
Sequence: MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGIIRVHGLADVMQGEMIALPGNRYAIALNLERDSVGAVVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGEPIDGKGSIENDGFSAVEAIAPGVIERQSVDEPVQTGYKSVDAMIPIGRGQRELIIGDRQTGKTALAIDAIINQRDSGIKCVYVAIGQKASTVANVVRKLEEHDALANTIVVVATASESAALQYLAPYSGCAMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVNAEYVEAFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESSLFNAGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQLSHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGYLGDVELAKVGSFEAALLAFADREHAELLQQINQTGAYNDEIEAKLKGILDTFKATQSW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LEU3_CORU7
Sequence: MKLAVIDGDGIGVEVTAEALKVLKAVRDDVETTEYDLGARRYLRNGETLTDADLESLKQHDAILLGAIGDPRTVPAGVLERGLLLPLRFKLDHAVNLRPSKLYPGASSPLKNAGEIDFVVVREGTEGLYCGNGGTLREGTDHEVASEVSQNTWFGVERVVRDAFRRAQERRKKLTWVHKTNVLVNAGGLWQRAIETIGKEFPDVEVDYNHIDAATIYMVTDPSRYDVIVTDNLFGDILTDLAGAVTGGIGLAASGNIDPTHNNPSMFEPVHGSAPDIAGQGIADPCAAILSVALMLRHLGDEANAEKIEKAVLDEAAGRDGSPIRTTEVGDRIAAAVQA
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIVJ_CITFR
Sequence: MNMKGKALLAGCIALSLSNMAFAKDIKVAVVGAMSGPVAQYGDQEFTGAEQAIADINAKGGVKGDKLVMVKYDDACDPKQAVAVANKVVNDGIKYVIGHLCSSSTQPASDIYEDEGILMITPAATAPELTARGYNLVLRTTGLDSDQGPTAAKYIVEKVKPKRIAIVHDKQQYGEGLARSVQDNLKKANADVVFFDGITAGEKDFSTLVARLKKENIDFVYYGGYHPEMGQILRQARAAGLKTQFMGPEGVANVSLSNIAGESAEGLLVTKPKNYDQVPANKPIVDAIKAKKQDPSGAFVWTTYAALQSLQAGLNQSDDPAEIAKYLKANSVETVMGPLSWDAKGDLKGFEFGVFDWHANGTATDAK
What is the function of this protein?
This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids.
What are the official names of this protein?
Leu/Ile/Val-binding protein, LIV-BP.
What is the protein family that this protein belongs to?
Belongs to the leucine-binding protein family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL22_DESAP
Sequence: MEAKAVARYIRLSPAKAREVVGLVRGKSVDEALAILRFTPQRAAGAVAKVIKSAAANAEHNNDMDRTRLVVAKVYVDQGPSLKRFRPRAYGRANVIKHRTSHITVIVSDGKEG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CK068_DANRE
Sequence: MAADESPASPSELSECFSAEDYAAESLAADLDPWITFDARKTPRAEFSSWLQSHRPSSVSRYGDGEAGAGPVGWIAVRGPDYSEQSGDVEGLQDSWETLLTSGRSVSFQNIRELALNHSVLDGKWLMHLDTGFKVDRAWESIARATVLEGKIWSAKVSPRDPSSNSRHVICVYNQNFTDEEQVVRLDSAIRAAGVKCVLYYKPDVYTYLGIYRNNRWKLCPTIYESMFDLESVPRRSHILNKVTNLELS
What are the official names of this protein?
UPF0696 protein C11orf68 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0696 family.
Protein: VHED_BPM1
Sequence: MFKRKSTAELAAQMAKLNGNKGFSSEDKGEWKLKLDNAGNGQAVIRFL
What is the function of this protein?
Binds preferentially to single-stranded DNA and therefore, destabilizes double-stranded DNA.  It is involved in DNA replication, repair and recombination.  Binds ss-DNA as the replication fork advances and stimulates the replisome processivity and accuracy.
What are the official names of this protein?
Single-stranded DNA-binding protein, Gp32, Helix-destabilizing protein.
Protein: RASD1_HUMAN
Sequence: MKLAAMIKKMCPSDSELSIPAKNCYRMVILGSSKVGKTAIVSRFLTGRFEDAYTPTIEDFHRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRDSFEEVQRLRQQILDTKSCLKNKTKENVDVPLVICGNKGDRDFYREVDQREIEQLVGDDPQRCAYFEISAKKNSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDVLHKKALRNKKLLRAGSGGGGGDPGDAFGIVAPFARRPSVHSDLMYIREKASAGSQAKDKERCVIS
What is the function of this protein?
Small GTPase.  Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).
What are the official names of this protein?
Dexamethasone-induced Ras-related protein 1, Activator of G-protein signaling 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. RasD family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Nucleus.
Protein: YGHR_ECOL6
Sequence: MDALQTQTVNSTTAPQPNYIPGLIAVVGCDGTGKSTLTTDLVKSLQQHWQTERRYLGLLSGEDGDKIKRLPLVGVWLERRLAAKSSKTQSMKTKSPALWAAVIMYCFSLRRMANLRKVQRLAQSGVLVVSDRFPQAEISGFYYDGPGIGVERATGKISMFLAQRERRLYQQMAQYRPELIIRLGIDIETAISRKPDHDYAELQDKIGVMSKIGYNGTKILEIDSRAPYSEVLEQAQKAVSLVAIVSDRRSLT
What are the official names of this protein?
Uncharacterized ATP-binding protein YghR.
What is the protein family that this protein belongs to?
To E.coli YghS and YghT.
Protein: YQGF_JANSC
Sequence: MIFETLDEFAGAVPPMRGLIGLDLGTKTIGVALSDRLLTSASALETVKRKKFGVDADALAGLIAKHEVGGIILGLPRNMDGSEGPRAQATRAFALNLSRRGDFAHLALGFWDERLSTVAAERALIAADTSRKRRSEVIDAVAASYILQGALDRLRHLRAV
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_STAES
Sequence: MAKRDYYEVLGVNKSASKDEIKKAYRKLSKKYHPDINKEEGADEKFKEISEAYEVLSDENKRANYDQFGHDGPQGGFGSQGFGGSDFGGFEDIFSSFFGGGSRQRDPNAPRKGDDLQYTMTITFEEAVFGTKKEISIKKDVTCHTCNGDGAKPGTSKKTCSYCNGAGRVSVEQNTILGRVRTEQVCPKCEGSGQEFEEPCPTCKGKGTENKTVKLEVTVPEGVDNEQQVRLAGEGSPGVNGGPHGDLYVVFRVKPSNTFERDGDDIYYNLDISFSQAALGDEIKIPTLKSNVVLTIPAGTQTGKQFRLKDKGVKNVHGYGHGDLFVNIKVVTPTKLNDRQKELLKEFAEINGEDINEQSSNFKDRAKRFFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_THEP1
Sequence: MRHRVKRHRLGRYGSHRKSLLRNLSREIVEHGSIVTTTAKAKALKILMDKLVSKAIEAATTDDKAKSVHLRRQINAVLGDRRLTNKLVDEIAKNYVGRHGGYVRVLRIGFRRGDAAEMSLVQLVEASSQEG
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: PMIP_ASPNC
Sequence: MGASLLLPLRRRPWTCRTCLLQARRSLETAASPATHRAAFDYLPSKNDAQKKSDDDTLRRVFDSQPFWREFSQRSAAHLKPTGLVQNQYLTSPDGFRVFATTTLQKCQAIVAKVLAGTTLEDYQSMARDLDRLSDLLCRVIDLSDFIRVIHPDPRVQEAATQAYALMFEYMNVLNTTTGLNDQLKKAAANPEVTARWSDEEKIVAQILIKDFSNSAIHMPPHARQRFVNLSNDISQLGNTFVNAAEPAKSHVTVSANSLRGLDPILVQQIKRWNRTASVPSMGLIPRLALRSVHDEGVRREVYLATRTSSARQIQRLEQLLAKRAELAQLSGYDSFAHMTLSDKMAKSPEAVSNFLTSLVGSNRPYVQEELAQLQSMKGSAGRLQPWDHAYYVHQRVLQYSQSRRSRELSAVPEFFSLGTVMQGLSRLFDRLYGVRLVPQETAAGETWNSDVRRLDVVDEADRHIAVIYCDLFSRPNKHPNPAHYTLRCAREISAEEVAECATTMDASAHPNDGMATAVDRDAKTLRQLPTIALVCDFPEPPATGTGRPSLLSEHSVRTLFHEMGHALHSILGQTRLQSISGTRCATDFAELPSVLMERFATAPEVLALYARHWETDAPLSESMMQHMEKDRTAHGSIYGAMENESQILMALVDQAYHSLPAGQATSIDSTAVFHQVSAEHCTLPDPTDTKPPTSWQGFFGHLHGYGATYYSYIFDRAIANKLWEDVFQQGKAAVDRQAGERYKNEVLRWGGGRNGWNCVAGVLGSAHPANADGRLVEGGDEAMREVGRWGLGRDGVSE
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.  While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP, Octapeptidyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RNFB_HAEI8
Sequence: MTFLFIVITLLALIFGAILGFASIKLKVEADPVVEKIDAILPQSQCGQCGYPGCKPYAEAICNGDEITKCIPGGQTTIVKIAEILGVDVPTMEGIEEPIEKVAFIDENMCIGCTKCIQACPVDAIIGTNKAMHTIIPDLCTGCELCVAPCPTDCILMIPVKKNIDNWDWKFDAKLVIPVMNVDGSEKKLVVGE
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: RL15_RHIEC
Sequence: MKLNEIKDNEGSTHSRKRLGRGIGSGSGKTAGRGVKGQKSRSGVAINGFEGGQMPIYRRLPKRGFNNIFASDFVVVSLARIQAAIDAGKLDAKATVDAAALKAAGVIRRAKDGVRVLADGDLKAKITIVVAGASKPAVEKIEKAGGTVTLLSAPAAAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: JIP5_PHANO
Sequence: MFENLCALQLDSDLFAQAIHPEEPIVAVGLASGHVQTYRLPPGASDDSDPDEALAAEKGFGHIATTWKTRRHKGSCRTLAFSVDGSSLYSAGTDGIVKVADTTTGRVTAKFAVPLDLANGGIDAPTLVHALSPQSLILGTDSSALHIYDIRDQGAKSAFKPQATHRPHDDYVSSLTPLPPTEASTSGFSKQWVTTGGSTLAVTDLRRGVMVRSEDQEEELLSSVMVTGLSKKGTSVGEKVLVGGGNGVLTLWERGVWDDQDERITIDRSKGGGESLDVIALLPDGVGPGGKIAAVGLGDGSLRFVKLGPNKIIDELKHDELRQEGVIGLGFDVTGRMVSGGGKKLNIWGEKTWQDVPEDDEDEQEEEAPANGKREHESDEDEDSDEDMEESSEDDEPKQKRKKRRKGKGGKQAKGHGILHFSGLA
What are the official names of this protein?
WD repeat-containing protein JIP5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: BXWO_WEIOS
Sequence: MDVLEMFDVNYESPILESFDSTTQSLNDVHVFMSRIQMSAYDADGEGRIEYRNLKLYEISSGIFISTDRLDTGASGVEDDHEMVDYYSSARLTREFLGESLDSQKSDYFEGIKKVFSFYKNKCNESRYIKEFFEEIQFRNICGFPKQAGTSSTDIFDQFNSVDVLLQDPVTSVWNKKVGSKKANIVIIPPATNLPITEACATAGFQPEGFPKLGSGSFFTVQFDPFFSTRFKAHETDDVALLDPTLTLLHEMTHGLHFQKGIANPVNRSGETPAWATTWGRVTGDNDAFKETPMEELLTFNKHTIDDDIEISDHLKSTYIGFLYNGRNEDDPTESVDGVYQNVSSFLNQYRGFEISSDFQHFIESCYGVKYNQESKKFIVNPRNIKRYVQDGFFIDEAKFARILNIKTRSYYTLMPDNLGVWSYRVDILNRLRETFDEDRGLLSQELDFHTALTPVVSENPALELEVAGMQRMVSLPKIKASYLPSDIKIKNFTGQKISHDTILDTNISGIIISKIKYKSDFVVDESMPRSSLNTTNYNLSPIKGTKFETDIRDKTSVKVTVSEITAPMINHVMKLDNSKVLTERPSLNEDLEETFKNTKDVYIPKTTAMMKLKEGADQTLGAVGFAVWSGQILEDLYNLAQKKEVSIDQIKDDLMSILPFYCAYKNLSAEKYEQAFANATLDAFLIFATDGGGFAGLGITVGAIAINSMYAKAETMEAYDSMFGKYVDQYQNDIKNFTLNAYVQWENNILSRLWNESRLAITGFRNMLKTVKTVMEFDATNQAYSEEDRKIIKAKCEEIFSEFPMLMQTFAKNSMTANLENASKIFNDIVWQKIKEELDQYVIDSKKYFLDSLEEAYNNGSISAESYYKYQTEAREKFVSPREVIDLYIAAHDTVVKRKRYIRRYSRKYDLATDFKGNTVHLNGLGEGTQDIQDLYGNYSVYADKKTVSTQEGHFDQTIKIAKDTNTINKVVLAVSSNNGKEYALNKDEQYTISFWLRMPVPSSSEERRIFSYSAVSGVNKEVEELILQVKNNEFVLATANLLRNSEFVIEPRIALNRWVKITIVNENTRIKVYQNDNLLGLIKDSSRKKPIAQRGTFKFYNYNVDYQLDDISYYNGTISQRDIKYTFKEDHGQFVYDHWGERLQYNKAYYLLSDDNKSAFETVYETKRLKLKSVPGVDIKYLGMNDRVYGYYGGLQFKLVPLDSKNMNNYVRWGDKFTMQSIETTNLSLAIIQDNAYFAPTQLKLISNEGKSEEEIFTFDRNIKLQNAAILVGTGNSKQGPISAYKRGYSGDLWINGARLDGYVTVVNKSNYSNDEIQEKFKWIFVPKDANWVE
What is the function of this protein?
When overexpressed the N-terminus (residues 1-476) cleaves rat synaptobrevin-2/VAMP2 between '89-Trp-|-Trp-90' in vitro.  This releases the cytoplasmic domain of VAMP2 from the synaptic vesicle membrane, which would prevent the assembly of the trans-SNARE complex on the membrane and thus prevent vesicle-target membrane fusion and neurotransmitter release (PubMed:27443638).
What are the official names of this protein?
Putative botulinum-like toxin Wo, BoNT/Wo.
What is the protein family that this protein belongs to?
Belongs to the peptidase M27 family.
Protein: ITPA_LEIMA
Sequence: MSTYGKVYLVSGNKGKLAEVQSYLAHANIVVEAVKFDLPETQNSSAEKISWDKAVEAYRVVNKMPVGEPLRHGGTPVLVDDTSLEFDALCGLPGPYIKWFLDRLGVEGLLKMVKGFAAPGEKDSGAAAPAHRGANAVCIISLCHGVEEATGQPLVEQFRGVCRGALPPVPRGGVGFGWDSIFAPEAQTPAYAKTFAEMSVEEKNTLSHRAKALKMLTEYLKTHALELRGTKLVA
What is the function of this protein?
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives.  The enzyme does not distinguish between the deoxy- and ribose forms.  Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine triphosphate pyrophosphatase, ITPase, Inosine triphosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLME_BORBZ
Sequence: MYRLDDEYSKKAKREGYLARSVYKLIEINEKFSLFSSGNVLDIGASPGSFSQYAYKKLKRGILVSVDINDIGLRYDDNFYFIKGDIFLDDTVFKINTFKPYSLVISDVAPKTTGNRLVDTSNSFNLSMRIIDLSLEVLLKKGNLLVKVFQGGDEMQIFKKFEKYFKFVKKIRPKAVRKNSFEIYFLGKSFGK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX51A_SCOAL
Sequence: MPSLCIIALFGTLTFYTLIPSIHTLKCVICDSPMGNYDCKTTYPAATECPGSSNNYCYKRETFASNGNLDQIRRNCNPVAASSKACKDLENGAKICEYSCNTDGCNSVAGMEPTRAVYFIAILMLTFYTFIRL
What are the official names of this protein?
U-scoloptoxin(05)-Sa1a, U-SLPTX(05)-Sa1a.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-05 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARCA_HAHCH
Sequence: MTAATRLGVFSEVGKLRKVMVCRPGLAHLRLTPGNCEELLYDDVIWVQQAKRDHYDFISKMQDRGVEVVDMHDLLAQTMALPDARQWLLDRKITDENVGVGLADDVRAWMSELSAASLAELLLGGVVGGDLPEDFDSREMALFREFMGRSGFVIPPLPNSIFTRDTSCWIYGGVTLNPMFWPARRQETLLAASIYRFHLDFANADFEVWWGDPEKDHGAATLEGGDVMPVGNGVVLIGMGERTSRQAIALVAQSLFRHGAAERVIVAGLPKLRSAMHLDTVFTFCDRDLVTVFPEVVNRIDTFSIRPGDNGADGRLDIRPEKAPFVDVVGEALGLPRLRTVQTGGDSYEQEREQWDDGNNVVALEPGVVIAYDCNTYTNTLLRKAGVEVITITAGELGRGRGGGHCMTCPIIRDPV
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXL1_YEAST
Sequence: MYNSIYGSPFPKINPKVRYKTALERAGFDTKPRNPFSSQRNASTGSLQASVKSPPITRQRNVSAAPSVPVTMKSAYTASSKSAYSSVKGESDIYPPPVLENSERRSVTPPKNSNFTSSRPSDISRSISRPSERASQEDPFRFERDLDRQAEQYAASRHTCKSPANKEFQAADNFPFNFEQEDAGNTEREQDLSPIERSFMMLTQNDTASVVNSMNQTDNRGVLDQKLGKEQQKEESSIEYESEGQQEDENDIESLNFEPDPKLQMNLENEPLQDDFPEAKQEEKNTEPKIPEINVTRESNTPSLTMNALDSKIYPDDNFSGLESSKEQKSPGVSSSSTKVEDLSLDGLNEKRLSITSSENVETPYTATNLQVEQLIAQLDDVSLSRNAKLDMNGNCLNAVDRKASRFKKSSAYLSGYPSMDIPVTQQTSIVQNSNTNLSRQTILVDKGDVDEDAPSESTTNGGTPIFYKFKQSNVEYSNNEGMGSQETFRTKLPTIEALQLQHKRNITDLREEIDNSKSNDSHVLPNGGTTRYSSDADYKETEPIEFKYPPGEGPCRACGLEVTGKRMFSKKENELSGQWHRECFKCIECGIKFNKHVPCYILGDEPYCQKHYHEENHSICKVCSNFIEGECLENDKVERFHVDCLNCFLCKTAITNDYYIFNGEIPLCGNHDMEALLKEGIDNATSSNDKNNTLSKRRTRLINFN
What are the official names of this protein?
Paxillin-like protein 1.
Protein: RS17_STRMK
Sequence: MSDNTEKKTLRTVEGRVVSNKMDKTVTVLVERQVKHALYGKYIKRSTKLHAHDADNACKEGDVVRVTEIAPMSKTKNWRVVEVITRAAE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: IHFA_PSEPF
Sequence: MGALTKAEMAERLYEELGLNKREAKELVELFFEEIRHALEDNEQVKLSGFGNFDLRDKRQRPGRNPKTGEEIPITARRVVTFRPGQKLKARVEAYAGTKS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: GLNT2_ALIF1
Sequence: MNFKLFGSALILSGTALGAGMLAIPMVLAQFGLFYSTLLMLIICAGTTYAALLLTEACSKTELAFGINTVANKTIGKGGQLVTNALFYLLLFCMLIAYILGAADLIKRIFSMMNVEMSIEFAQVAFTLFASAFVVCGTQIIDKLNRLLFFFMISMLVLTLIILIPGMTVENLSQVTNHDKGMLFDTSTILFTSFASMPVIPSLVAYNKEATKQQLRNMVILGSIIPLICYLVWLYAVVGNLTANEITHFSNISDLIQTFSAKNEYIEIILSIFTSLALLTSFLGVAMALYNQNKDMISHNKIVTYVCTFILPLLGAGLAADQFLSVLGYAGVILVFLAIFIPLAMVVTLRKKETEEVHQNLHIYTAEGGKLALGLTLLFGLLLLISQI
What is the function of this protein?
Seems to be involved in glutamine transport.  Complements an E. coli glnP deletion mutant.
What are the official names of this protein?
Glutamine transporter 2.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.