PharMolix/UniProtQA huggingface dataset:
Protein: CITG_ECOLC
Sequence: MSMPATSTKTTKLATSLIDEYALLGWRAMLTEVNLSPKPGLVDRINCGAHKDMALEDFHRSALAIQGWLPRFIEFGACSAEMAPEAVLHGLRPIGMACEGDMFRATAGVNTHKGSIFSLGLLCAAIGRLLQLNQPVTPTTVCSTAASFCRGLTDRELRTNNSQLTAGQRLYQQLGLTGARGEAEAGYPLVINHALPHYLTLLDQGLDPELALLDTLLLLMAINGDTNVASRGGEGGLRWLQREAQTLLQKGGIRTPADLDYLRQFDRECIERNLSPGGSADLLILTWFLAQI
What is the function of this protein?
Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.
What are the official names of this protein?
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: Y1993_STAS1
Sequence: MTKKQFKHGVLFYHEHTGIKDIYRGLGDVATSLTTFCRHLSIQLSENEGDIITFCQKIKDKRYSDDVDIIFILGGDGTVNELVNGIMKSELNLPIGIIPGGTFNDFVKTLNLNPRHKMASQQLMNAELRPYDVMKINDEYALNFVGLGLIVQNAENVQNGNKDIFGKLSYVGSTVKTLLNPEHFDYKISVDNQTVDGNTSMLVVANGPFIGGSRIPLTDLSPNDGYLNTFIFKEQSSSVLNDVFKQRDSMNWNKMTEGIKHLPAKKITIETDPQMKVDIDGEINLKTPLEIEVIPNAIQILTLPEAQATNQPESE
What is the function of this protein?
May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG).
What are the official names of this protein?
Putative lipid kinase SSP1993.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family.
Protein: RL30_BIFLO
Sequence: MAKNLKITLHHGIVNRTPAQRATVKTLGLNKIGKTVVREDTPANRGLVNAVRHLVTVEEVD
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: CLPP_CHAGL
Sequence: MPVGVPKVPYRLPGDVQVQWIDLYNRLYRERILFLGQTVNYEIANQIIGLMLYLNGDDKSKDMYLYINSPGGAVVPGIAIYDTMQFVEPEIRTICMGVAASMGSFILTGGEITKRIALPHARVMIHQPSSSYYKDQAGELIMEAEEVLKLRDCITKVYVQRTGKPISVISEDMERDVFMSAKEAKEYGIVDLVALDVDSNS
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: TV23B_HUMAN
Sequence: MLQQDSNDDTEDVSLFDAEEETTNRPRKAKIRHPVASFFHLFFRVSAIIVYLLCGLLSSSFITCMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKSHWVFESRKESSQENKTVSEAESRIFWLGLIACPVLWVIFAFSALFSFRVKWLAVVIMGVVLQGANLYGYIRCKVRSRKHLTSMATSYFGKQFLRQNTGDDQTS
What are the official names of this protein?
Golgi apparatus membrane protein TVP23 homolog B.
What is the protein family that this protein belongs to?
Belongs to the TVP23 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TSAD_BDEBA
Sequence: MIERVLAIETSCDDTSVAIVDRTGWVHSVVAASQDLDHEIYGGIVPEIAARNHSIALIPLIEEAFKKANMNWSDVQGIAVTNRPGLIGALIVGLVTAKSLSQAKHLPFLGVNHLEGHLLAPFLRDDKYAPPEDFGYPYVGLAISGGHTSLYQIKGLGDYRILGATKDDAAGECFDKFAKMAGLGFPGGVRVDQMAKAGNPQAFEFPRSMIHDDTFDMSFSGLKSSGQRMLEQLGPELVQERLPDLCASFQEAIVDVLIAKLDRAAKVFRSKRVILTGGVSANSRLRQRAQEWADKKGYTLVIPPLRYCTDNAAMIGYVGALRMARGEVSALDLGPSPQALASDFK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBP_ACEPE
Sequence: MTGDVDMSLHPSGIIPELQNVVSTVNLGCTLELKEIAMQARNAEYNPKRFAAVIMRIRDPKTTALIFGSGKMVCTGAKSEQDSRTAARKYAKIVQKLGFPAKFTEFKIQNIVGSCDVKFPIRMEPLAYQHQQFCSYEPELFPGLIYRMLQPKIVLLIFVSGKVVLTGAKERTEIYRAFEQIYPVLTQFRKR
What is the function of this protein?
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID.  Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
What are the official names of this protein?
TATA-box-binding protein, TATA sequence-binding protein, TBP, TATA-binding factor, TATA-box factor, Transcription initiation factor TFIID TBP subunit.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YOAH_ECO45
Sequence: MFAGLPSLTHEQQQKAVERIQELMAQGMSSGQAIALVAEELRANHSGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: EIF3K_CRYNJ
Sequence: MVTAVSPENLKEWHTPSTRPDVIHELIHGVDRYNPSNLPFMEDYLATELKEGQYDLFGNLAILKLYQFNPQHSNPDVIINILIKALAATVSGPDFNLCLEMLREPSAILHDIESADEALVIVMPYLQRLHELSRTCQFTKFWQEINSDSEAAKILRTRYLPQHASPLDDFRFIFSASIASCFRRISLSQLSRWLDIPSDKVGEWCSKVEWTVEGQDAVIPNNGQNDVKAGVVKENVQLGQLTKLVAAAGY
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit K, eIF3k, eIF-3 p25.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit K family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_CUPPJ
Sequence: MLNFELITTDGNARRGRVTLNHGVVETPIFMPVGTYGSVKAMSPLELNEIGAEIILGNTFHLWLRPGLDVVNTHEGLHRFIGWDKPILTDSGGFQVFSLGDLRKITEDGVTFASPVNGDKLFLSPEISMQIQRTLNSDIVMQFDECTPYEIEGRPATHEEAAKSMRMSLRWAKRSRDEFERLANPNALFGIVQGGMFEDLRDESLAGLSELDFHGFAIGGLSVGEPKEDMMRVLEHVAPRLPADKPHYLMGVGTPEDLVAGVAAGVDMFDCVMPTRNARNGWLFTRYGDVKIRNAAHRNDPRPLDESCACYTCRNFSRAYLHHLHRVGEILGARLNTIHNLHYYLQLMREVRESIEQHRFSDFRRQFASDRARGTR
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PYRG_CHRVO
Sequence: MTKYIFVTGGVVSSLGKGIAAASIAAILESRGLKVTMLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIHAKMKKSNNFTTGQVYESVITKERRGDYLGGTVQVIPHITDEIKLKMGEGAADADVAIVEIGGTVGDIESLPFLEAIRQMRSNHGRKNTLYVHLSYVPYIATAGEIKTKPTQHSVKELREIGIQPDILLCRMDRELPEDEKRKIALFCNVEENAVIGCYDSDSIYKVPGMLHAQGIDDIIAEQLQLDLPQADLSAWDRIIDAIEKPDHAIKIAMVGKYVDLTESYKSLTEALKHAGIHTRTKVDIIYVDSEEIERDGAESLRDMDAILVPGGFGKRGVEGKIKAVKFARENDIPYLGICLGMQIALIEYARDVAGMAGANSTEFDLDTNFPVVALIDEWVNHDGKIEKRDENSNMGGTMRLGGQQCDLVPGSLAARVYGSTEITERHRHRYEVNNYYIQRLEQAGLTISGRSAGHEKLVETIELTGHRWFFACQFHPEFTSTPRDGHPLFIAYVKAALAHQADKQAS
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: CSN4_ARATH
Sequence: MDEALTNASAIGDQRQKIEQYKLILSSVLSSNDLLQAQRFIDHILSDDVPLVVSRQLLQSFAQELGRLEPETQKEIAQFTLTQIQPRVVSFEEQALVIREKLAGLYESEQEWSKAAQMLSGIDLDSGMRAVDDNFKLSKCIQIARLYLEDDDAVNAEAFINKASFLVSNSQNEVLNLQYKVCYARILDMKRKFLEAALRYYGISQIEQRQIGDEEIDENALEQALSAAVTCTILAGAGPQRSRVLATLYKDERCSKLKIYPILQKVYLERILRRPEIDAFSEELRPHQKASLPDKSTVLDRAMIEHNLLSASKLYTNIRFDELGTLLAIDPRKAEKIAANMIGQDRMRGSIDQEEAVIHFEDDVEELQQWDQQISGLCQALNDILDGMAKKGMSVPV
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF.  It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes.  The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.
What are the official names of this protein?
COP9 signalosome complex subunit 4, AtS4, Signalosome subunit 4, Constitutive photomorphogenesis protein 8, Protein FUSCA 4.
What is the protein family that this protein belongs to?
Belongs to the CSN4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL33A_CANAL
Sequence: MAESHRLYVKGKHISYQRSKSVTNPNVSLIQIEGVASPKDAKFYLGKRIAYVYRAPKEIRGSKIRVIWGKVTRTHGNNGLVRANFKKNLPPKTFGASVRIMLYPSNI
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L33-A.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL33 family.
Protein: REC8_SCHPO
Sequence: MFYNQDVLTKEKGGMGVIWLAATLGSKHSLRKLHKKDIMSVDIDEACDFVAFSPEPLALRLSSNLMIGVTRVWAHQYSFFHSQVSTLHLRVRKELDHFTSKPFKNIDIQNEQTNPKQLLLAEDPAFIPEVSLYDAFNLPSVDLHVDMSSFTQPKENPNISVLETLPDSTSYLINTSQNYSLRNNVSSFVYEDSRAFSTEEPLDFEFDENGDIQELTKGTINSDPSLQAASQHSNLGSVQREYNSEEQESRIHMFEIDEDVLPLPVPLQSVMDSEHNENEPRALKRRKVQKLLEPDENIELSTRTLSQWRKNYVERMIALEATKYVRRRGASSAKKKELNKFFDWESFHPLLKPWIEKLKPSNNTPSEIDDVLRNIDTSEVEVGRDVQGELGLNIPWNTSSRSNSAINSKSHSQTGSEHSTPLLDTKYRKRLPHSPSMPSRVEFLPALESSQFHETLNSELSLQLSDDFVLYKNTQEENAHLMLSMEKECANFYEYAKTAIYENNGRITFSSLLPNDLKRPVVAQAFSHLLSLATKSAFLVKQDKPYSEISVSLNLKSTDAI
What is the function of this protein?
Involved primarily in the early steps of meiotic recombination.  Required to ensure reductional chromosome segregation.
What are the official names of this protein?
Meiotic recombination protein rec8, Cohesin rec8.
What is the protein family that this protein belongs to?
Belongs to the rad21 family.
Protein: PURL_STAAE
Sequence: MSKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHSKPFLKQFPTSGDHVLMGPGEGAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSLRFGELDNKQNQRLLKGVVKGIGGYGNCIGIPTTAGEIEFDERYDGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESKRPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQVPTREPGISPYEMMLSETQERMLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLTYDDEVYADIPVEPLADEAPVYILEGEEKDYNTSKNDYTHIDVKDTFFKLLKHPTIASKHYLYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAYRNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNETKGTSIFPTPVVGMVGLIENVNYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHEFESLDLSSEVEKGESIKTAIREGLLSHVQTVGKGGLLITLAKLSAHYGLGLKSSIDITNAQLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGAIAQCLTTQD
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y066_PASMU
Sequence: MLAIISPAKTLDFESAVPKFEFSQPQLTEYSAQLIDVCRQLSPAEIGSLMSISDKLAGLNFARFAEWQKAHTEQNSRAAIYAFKGDVYTGLDVESLSQQDVLFAQQHLRMLSGLYGLLKPLDLMQPYRLEMGTKLVNSKGKDLYAFWGNVITDTLQQAIEAQGDNVLVNLASDEYYKSVKESQLNVRIIKPVFLDNKNGKYKVISFYAKKARGLMCRYIIQNRLSEVEQLKGFDLGGYWFDPTSSSETEFVFKRDVAE
What are the official names of this protein?
UPF0246 protein PM0066.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: RL17_CLAMS
Sequence: MPKPTKGPRLGGGPAHERLMLANLAQSLFEHKSIKTTETKAKRLRPVAERLVTFAKRGDLHARRRVMGIIPSKSVVHELFTEIAPLVAERDGGYTRITKLGFRKGDNAPMVQIELVLEPVTPKVRSSRTSTATAPVAAAPVAEAPAEESDVPVEETDAVEHTDETPAETTDAAAAEVEADAAEKSDK
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: CD3E_MACFA
Sequence: MQSGTRWRVLGLCLLSIGVWGQDGNEEMGSITQTPYQVSISGTTVILTCSQHLGSEAQWQHNGKNKEDSGDRLFLPEFSEMEQSGYYVCYPRGSNPEDASHHLYLKARVCENCMEMDVMAVATIVIVDICITLGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQQDLYSGLNQRRI
What is the function of this protein?
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.  When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.  All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.  Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.  In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development.  Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E.  Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
What are the official names of this protein?
T-cell surface glycoprotein CD3 epsilon chain.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: FTHS_PICTO
Sequence: MKNISEIINIPEDYYDLYGRYIAKVSLNVLDYLKNKRYGKLILVTAMTPTPAGEGKTTTAIGLGNALKLLGKNAGIAIREPSLGPCFGVKGGATGGGKSTVEPSNKINLMFTGDFPAVSAAHNLLSAVINNHMYHGNELKLDPKNIVFPRTIDMDDRSLRSIIVGSGDRSTGVMMNDKYVITAASEVMAILALSRNYNELKQRLGNIMIGYNLNKAPIFARDLKVHGAMASLLVDALRPNIAQTSEHVPAIIHTGPFGNIAHGTSSILGDIIGLKMFDYLVTEAGFGSDLGFEKFIDIVLRLSDFKLSAVVLVATVRAMRYHGGGRINEPDVNAVLRGSENLMWHVQNIKKFGFNPVVAINRHSNDTDAEINAISNILTKNGVEFSISDAYSDGGHGALDLAGKVLKSISDYNPRYIYGINDDPEEKISKIAMNVYNANSVEFSHDAVKTMKLIKDDFSDLYVCMAKTQSSISDNAKLINVPEGFTVKINGININSGSGFIIPLLGNIMTMPGLPRRPASENIDIDDYGNITGLQ
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: QUEA_RICRO
Sequence: MKLSDFDFDLPSELIAQYPSSERDNSDLLIAVTPPIKTKFYNIIDYLKEGDLLVFNNSKVIKAQLNLGKNITINLNQKLSDDSWSAFAKPARKLHVNDEFYFDNHKVIITEKLAMGEIKVKFKLNDISVFEFLNKYGEMPLPVYIRRSHSLCHPVATTTGSKTYLNNDWIPWSNHGMTNTQNDNDRYQTVYSQIEGSVAAPTAGLHFTKDILDKLKAEGIQATFLTLHVGAGTFLPVKTENIHEHKMHTEYCSITPDTAEIINKAKQEGKRIIAVGTTTLRTLESSCNNGIVKAGSFKTDIFITPGFKFQTADMLLTNFHFPKSTLFMLICAFAGFKEMHELYKYAIKEAMRFFSYGDATLLCRK
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FENR_HALH5
Sequence: MSRKEELYDITIIGGGPTGLFAAFYGGMRQAKVKIIESMPQLGGQLAALYPEKYIYDVAGFPKVKAQDLVNDLKRQAEQFNPTIALEQSVQNVTKETDDTFTIKTDKETHYSKAIIITAGAGAFQPRRLEVEGAKQYEGKNLQYFVNDLNAYAGKNVLISGGGDSAVDWALMLEPVAKNVTLIHRRDKFRAHEHSVELLQKSSVNILTPFAISELSGDGEKIHHVTIQEVKGDAVETLDVDEVIVNFGFVSSLGPIKGWGLEIEKNSIVVNTKMETNIPGIYAAGDICTYPGKVKLIATGFGEAPTAVNNAKAFIDPTARVFPGHSTSLF
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: MURA1_STRPN
Sequence: MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQNVPILSDVFIMNQVVGGLNAKVDFDEEAHLVKVDATGDITEEAPYKYVSKMRASIVVLGPILARVGHAKVSMPGGCTIGSRPIDLHLKGLEAMGVKISQTAGYIEAKAERLHGAHIYMDFPSVGATQNLMMAATLADGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETITITGVEKLHGTTHNVVQDRIEAGTFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVEVIEEDEGIRVRSQLENLKAVHVKTLPHPGFPTDMQAQFTALMTVAKGESTMVETVFENRFQHLEEMRRMGLHSEIIRDTARIVGGQPLQGAEVLSTDLRASAALILTGLVAQGETVVGKLVHLDRGYYGFHEKLAQLGAKIQRIEASDEDE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1, Enoylpyruvate transferase 1, UDP-N-acetylglucosamine enolpyruvyl transferase 1, EPT 1.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA2_DESPS
Sequence: MNYFRVKIAYKGTHYFGWQAQSIDTLHEEKPTVEGTILNALKKITNYQPCTVSGASRTDGGVHARGQIAKITISQKISPEHLLLGLNSLLPTDIRILECVPSTKEYQASRGSVSKEYHYYFIASPVDNVATSDIALHLPIDSIGPDDLALLRSACRLFVGRHDFYNFSSRGSGTSFREIFYCDIHRANFSPLANDMFYLKIIGDGFLKYMIRYIMGALLELVRGRIVLDDISLYLQQHQEDKLSPRAKAKGLHLIRIEGPK
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A 2, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I 2, tRNA-uridine isomerase I 2.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: GCSH_NITEC
Sequence: MSVPAELKYAKSHEWIKLEADGTVTVGITQHAQELLGDMVFVELPKVGRILAQQEDCAVVESVKAASDIYAPLSGEVIAINAEVESSPEKINEDSYSAWLFKLKPANTAEIDGLLDANGYEKLLESDAH
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RECX_BACAH
Sequence: MAVITKIEVQKRSKERFNIYIDKGQGEEYGFSVNEVILIKHGLQKGLEIDEIALGNILYNEEVQKAYLQAISYLSYQMRTKLEIEDFLRKKEVGQAIISEVVSKLLHDRYINDKEYAILYTRTQSNVNRKGPTVIKRELLNKGVQDLIITHSLQEYPKEKQIENALILIEKKKKSYQKHSFLQMKLKLDEMLVRKGYSRDVIQICLEELKDEKDDEKQQEALHYHGNKYYEKYKKYDGWTFENKMKQALYRKGFSIDEIEIFLQMKREEG
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_COREF
Sequence: MLAPRRKTRQLMVGSVGVGSDHPISVQSMTTTKTHDINATLQQIAQLTASGCDIVRVACPKPVDAEALPIIAKKSPIPVIADIHFQPKYIFSAIDAGCAAVRVNPGNIKEFDGRVKEVAQAAGDAGIPIRIGVNGGSLDKRILDKYHGKATPEALVESALWEASLFEEHGYGDIAISVKHSDPVLMVEAYRQLAEKCDYPLHLGVTEAGPKFMGTIKSSVAFGALLSQGIGDTIRVSLSADPVEEIKVGDQILQSLNLRPRKLEIVSCPSCGRAQVDVYKLAEEVTEGLDGLEVPLRVAVMGCVVNGPGEARDADLGVASGNGKGQIFVKGEIIKTVPESQIVQTLIEEAMRIAETMDPEVLAAAEASGMKAEVKVTS
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: ETDA_HUMAN
Sequence: MDKEVPKGSPREPALNIKKSDKSFKRKKPTENVLIFLINRQLGRHRSDIDLSRWVWMLS
What are the official names of this protein?
Embryonic testis differentiation protein homolog A.
Protein: SOPA_SALTY
Sequence: MKISSGAINFSTIPNQVKKLITSIREHTKNGLTSKITSVKNTHTSLNEKFKTGKDSPIEFALPQKIKDFFQPKDKNTLNKTLITVKNIKDTNNAGKKNISAEDVSKMNAAFMRKHIANQTCDYNYRMTGAAPLPGGVSVSANNRPTVSEGRTPPVSPSLSLQATSSPSSPADWAKKLTDAVLRQKAGETLTAADRDFSNADFRNITFSKILPPSFMERDGDIIKGFNFSNSKFTYSDISHLHFDECRFTYSTLSDVVCSNTKFSNSDMNEVFLQYSITTQQQPSFIDTTLKNTLIRHKANLSGVILNEPDNSSPPSVSGGGNFIRLGDIWLQMPLLWTENAVDGFLNHEHNNGKSILMTIDSLPDKYSQEKVQAMEDLVKSLRGGRLTEACIRPVESSLVSVLAHPPYTQSALISEWLGPVQERFFAHQCQTYNDVPLPAPDTYYQQRILPVLLDSFDRNSAAMTTHSGLFNQVILHCMTGVDCTDGTRQKAAALYEQYLAHPAVSPHIHNGLFGNYDGSPDWTTRAADNFLLLSSQDSDTAMMLSTDTLLTMLNPTPDTAWDNFYLLRAGENVSTAQISPVELFRHDFPVFLAAFNQQATQRRFGELIDIILSTEEHGELNQQFLAATNQKHSTVKLIDDASVSRLATIFDPLLPEGKLSPAHYQHILSAYHLTDATPQKQAETLFCLSTAFARYSSSAIFGTEHDSPPALRGYAEALMQKAWELSPAIFPSSEQFTEWSDRFHGLHGAFTCTSVVADSMQRHARKYFPSVLSSILPLAWA
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway (PubMed:28084320).  For instance, prevents host innate immune response by ubiquitinating and thus sending to degradation host E3 ubiquitin ligases TRIM56 and TRIM65 (PubMed:28084320).  Required for inducing polymorphonuclear leukocytes migration across the intestinal epithelium.  Preferentially uses host UBE2D1 (UBCH5A), UBE2D2 (UBCH5B) and UBE2L3 (UBCH7) as E2 ubiquitin-conjugating enzymes.
What are the official names of this protein?
E3 ubiquitin-protein ligase SopA, HECT-type E3 ubiquitin transferase SopA, Salmonella outer protein A, Secreted effector protein SopA.
What is the protein family that this protein belongs to?
Belongs to the SopA E3 ligase family.
What are the subcellular locations of this protein?
Secreted. Host cell. Note=Secreted via type III secretion system 1 (SPI-1 TTSS), and delivered into the host cell. Can also be secreted through the flagellar export apparatus.