PharMolix/UniProtQA huggingface dataset:
Protein: NDUS3_ARATH
Sequence: MDNQFIFKYSWETLPKKWVKKMERSEHGNRFDTNTDYLFQLLCFLKLHTYTRVQVLIDICGVDYPSRKRRFEVVYNLLSTRYNSRIRVQTSADEVTRISSVVSLFPSAGWWEREVWDMFGVSFINHPDLRRILTDYGFEGHPLRKDFPLSGYVQVRYDDPEKRVVSEPIEMTQEFRYFDFASPWEQRSDG
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, NADH dehydrogenase subunit 9.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: SR541_SOLLC
Sequence: MVLAQLGGSISRALQQMSNATIIDEKVLNECLNEITRALLQADVQFKLVRDMSTNIKKIVNLEDLAAGHNKRRIIQQAVYNELCKILDPGKPAFTLKKGKPSVVMFVGLQGSGKTTTCTKYAYHHQKRGWKPALVCADTFRAGAFDQLKQNATKAKIPFYGSSYTESDPVKIAVDGVETFKKENCDLIIVDTSGRHKQEAALFEEMRQVSEAQKPDLVIFVMDSSIGQAAFDQAQAFRQSVAVGAVIVTKMDGHAKGGGALSRVAATKSPVIFIGTGEHMDEFEVFDVKPFVSRLLGMGDLSGLVNKIQDVVPMDQQPELLQKLSEGHFTLRIMYEQFQSMLKMGPLGVFSMLPGFSAEMMPQGREKESQAKFKRYMTMMDSMTDEELDSTNPKILTESRIMRIARGSGRLVHEVMEMLEEYKRLAKIFSKMKGLKIPKKGDMSSLSRNMNAQNMSKVLPPQMLKQIGGMGGLQNLMKQMGSAKDMMGMFGGGGGE
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).  As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane.  Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.  Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA.  Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA.  SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity).  Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity).
What are the official names of this protein?
Signal recognition particle subunit SRP54 1, Signal recognition particle 54 kDa protein 1, SRP54.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNAS1_HYDHY
Sequence: AESSAMKFQRQHVDSEGSSSSNANYCNEMMVRRKMTQDRCKPVNTFVHEPLADVQAVCFQKNVPCKNGQTNCYQSYSSMHITDCRVTSNSKFPDCSYRTTQAQKSIVVACEGNLYVPVHFDASVEPST
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: FMT_HYDCU
Sequence: MTQPLRIIFAGTPDFSVPPLKTLIDSEHEVVAVYTQPDRPAGRGRKLTASPVKQTALEHDIPVYQPVSLKTPEAQAELEALQADVMIVVAYGLILPKAVLDMPKYGCLNIHASILPRWRGAAPIQRAIQMGDAETGVTIMQMDVGLDTGDMLTILKTPIKPEDTAQTLHDRLSALGCDAMMTTLSNLQTDQLSPVKQDERQVTYAEKLNKAEAELDWQASAQTLARQVQAFNPWPVAFTQYQGQPLRIWQAEVGHASTQKSPGLVISVSKTGMEVATGKGSLLIKQVQPSGKKAMPAYDFAQARQLTGQTLG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: TPIS_SYNR3
Sequence: MSTQSRPVVIAGNWKMHMTCAQAKQYAAAFLPQVANAPKDRSIVLAPPFTAISTLQEALAGSDVQIASQNVHWKDSGAFTGEISAEMLLELGVGYTIVGHSEPRKYFSESDEQINQRARASQAAGLIPILCVGESDEQRSSNETERVIRRQVEQGLEGIDPSKLVVAYEPIWAIGTGKTCESEEANRVCGLIRNWVGYPNLTIQYGGSVKPGNIDELMAKSDIDGVLVGGASLEPDSFARIANYQMASAAAAA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSA_ACTPL
Sequence: MTILNKIVKVGNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLGVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDTFGVSIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGVVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDRGTNFGYDNLVVDMLGFNIMKKVSKGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLVKSFEEIDTSR
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NS1_PAVL3
Sequence: MAGNAYSDEVLGTTNWLKDKSNQEVFSFVFKNEDVQLNGKNIGWNSYRKELQEEELKSLQRGAETTWDQSEDMEWESSVDELTKKQVFIFDSLVKKCLFEVLSTKNIAPSDVTWFVQHEWGKDQGWHCHVLIGGKNFSQAQGKWWRRQLNVYWSRWLVTACSVQLSPAERIKLREIAEDQEWVTLLTYKHKQTKKDYTKCVCFGNMVAYYFLTKKKICTSPPRDGGYFLSSDSGWKTNFLKEGERHLVSKLYTDDMRPETVETTVTTAQETKRGRIQTKKEVSIKTTLKELVHKRVTSPEDWMMMQPDSYIEMMAQPGGENLLKNTLEICTLTLARTKTAFDLILEKAETSKLTNFLLADTRTCRIFAFHGWNYIKVCHAICCVLNRQGGKRNTVLFHGPASTGKSIIAQAIAQAVGNVGCYNAANVNFPFNDCTNKNLIWVEEAGNFGQQVNQFKAICSGQTIRIDQKGKGSKQIEPTPVIMTTNENITVVKIGCEERPEHTQPIRDRMLNIHLTHTLPGDFGLVDKNEWPMICAWLVKNGYQSTMASYCAKWGKVPDWTENWAEPKVTTEINSVGSTNSPSPKSTPLSQNYALTPSDLEDLALEPWSTPSTPVVGTVKTPNTGETGSTACQEAQRSPTWSEIEEDLRACFSSEHWKSDSEQLPNLD
What is the function of this protein?
Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication.  Also plays a role in viral packaging and transactivation of several promoters.  Binds site-specifically to 2-3 approximate tandem copies within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR).  Cooperatively binds Ori with host PIF and probably other host factors, which activate the nickase function of NS1.  Becomes covalently attached to the 5' end of the nick and provides a 3'OH for priming DNA synthesis.  The helicase activity unwinds DNA in a 3'-5' direction on the longer strand.  Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition.  These arrests may provide essential cellular factors for viral DNA replication.  Promotes apoptosis in host cell.
What are the official names of this protein?
Initiator protein NS1, NS1, NCVP1, Non-capsid protein NS-1, Non-structural protein 1, Non-structural protein NS1.
What is the protein family that this protein belongs to?
Belongs to the parvoviruses initiator protein NS1 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: Y1047_STAAS
Sequence: MAKQATMKNAALKQLTKDADEILHLIKVQLDNLTLPSCPLYEEVLDTQMFGLQKEVDFAVKLGLVDREDGKQIMLRLEKELSKLHEAFTLV
What are the official names of this protein?
UPF0358 protein SAS1047.
What is the protein family that this protein belongs to?
Belongs to the UPF0358 family.
Protein: CHMO_BETVU
Sequence: MAASATTMLLKYPTLCAMPNSSSSSNNNDLPTSIPLNNNNNLLSNKNKILQTPNINTSTNKIITKAVASPVFPTLKTTSNTPSSIRSLVHEFDPEIPPEDALTPPSTWYTEPAFYSHELERIFYKGWQVAGYSEQVKEKNQYFTGSLGNVEYLVSRDGQGELHAFHNVCTHRASILACGSGKKSCFVCPYHGWVYGLDGSLAKASKATETQNLDPKELGLAPLKVAEWGPFILISLDRSLDANADVGTEWIGKSAEDVKAHAFDPNLKFTHRSEFPMECNWKVFCDNYLDSSYHVPYAHKYYAAELDFDTYNTEMIEKCVIQRVGSSSNKPDGFDRLGTEAFYAFIYPNFAVERYGTWMTTMHVVPMGQRKCKLVVDYYLEKAMLDDKAYIDKGIAINDNVQKEDKVLCESVQRGLETPAYRSGRYVMPIEKGIHHFHCWLHETLQ
What is the function of this protein?
Catalyzes the first step of the osmoprotectant glycine betaine synthesis.
What are the official names of this protein?
Choline monooxygenase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the choline monooxygenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: VA0D_DICDI
Sequence: MGLFGGRKHGGLFTFNKDDGYLEAILRGFKKGILSRADYNNLCQCDNLEDMKMHFISTDYGDFLAGEPSPIHTTTIAEKATGKLVSEFNHIRNQAVEPLSTFMDFISYGYMIDNVVLLITGTLHERDISELVDKCHPLGLFKSMATLSVVHNVADLYNNVLIDTPLAPYIQGCLSEEDLDEMNIEIIRNTLYKAYLEDFYNYCKYLGGQTELIMSDILKFEADRRSINITINSFGATELSKDDREKLYPSLGLLYPEGTSKLGKAEDVDQVRGILEVYSTYRNFFSDGVNNEKSLEDSFFEHEVHLNRMAFEDQYGYGVFYAYIKLREQEIRNIVWIAECISQNMKQKMNQYIPIF
What is the function of this protein?
Subunit of the integral membrane V0 complex of vacuolar ATPase.  Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
What are the official names of this protein?
V-type proton ATPase subunit d, V-ATPase subunit d, DVA41, V-ATPase 41 kDa accessory protein, Vacuolar proton pump subunit d.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase V0D/AC39 subunit family.
Protein: Y207_AERPE
Sequence: MGGEGPGSDDIVKKMAQLMMQGAVMLDKTCPADGLPLFKLKTGDVVCPVHGKVVIVASDEEARDVEVEEIIREVRYRAARNVMKGLEEDNVDTVSKWLGVLETAERILAIRRGSRQGQGSVRGEGRESK
What are the official names of this protein?
UPF0148 protein APE_0207.
What is the protein family that this protein belongs to?
Belongs to the UPF0148 family.
Protein: LHX3_HUMAN
Sequence: MLLETGLERDRARPGAAAVCTLGGTREIPLCAGCDQHILDRFILKALDRHWHSKCLKCSDCHTPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGGSKSDKDSVQEGQDSDAEVSFPDEPSLAEMGPANGLYGSLGEPTQALGRPSGALGNFSLEHGGLAGPEQYRELRPGSPYGVPPSPAAPQSLPGPQPLLSSLVYPDTSLGLVPSGAPGGPPPMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF
What is the function of this protein?
Transcription factor.  Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2.  Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity).  Required for the establishment of the specialized cells of the pituitary gland and the nervous system (PubMed:21149718).  Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (By similarity).
What are the official names of this protein?
LIM/homeobox protein Lhx3, LIM homeobox protein 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1395_ARCFU
Sequence: MVLEMKVIAFVGYPLSGKSTAAEVARELGLPVVVMGDVVREEAARRGLELTDENLGKVARELREKEGMDAIAKRCIPKIRELLKEHGVVVVDGIRGVAEVERFKKAFGDDFVLIAIECPLEVRFERVKMRKRSDDVSSIEELKERDRREESWGLKEAMEMADFTVENTGSYEDFVEKIRQILLKLAKNVEIEIRTKIHPTESEDKVLKAIRNIFPDAEIEISEEGEVYGRAYSLDRFRELLRKQRILDTARSEILKGRNGKEVTIYLNKQTATVSRINFCDENAVLSPIKVTFRLNNIPFSRFLDYIAPETKDGRPVKEIDKL
What are the official names of this protein?
UPF0200/UPF0201 protein AF_1395.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the UPF0201 family.
Protein: WWOX_DANRE
Sequence: MAALKYAGMEDTDSEDELPPGWEERSTKDGWVYYANHEEMKTQWEHPKTGKKKRCAGALPYGWEQETDDKGQIFYVDHINKRKTYFDPRQAFTVEDMQVKPKRYDGNTGALEILHGQDLSDKVIIVTGANSGIGFETARSFALHGAHVILACRNQSRASKAASLIMGEWSKARVEVLPLDLASLRSVRQFAELFKATKLPLHVLVCNAAVCSQPWRLTEDGFESTFQICHLGHFLLVQLLQDVLRLSAPARVVVVSSESHRFTDLLDSCGNLDLDLLSPPQKNYWSLLAYNRAKLCNLLFSSELHRRMSPHGICCNALHPGSMMFTSIHRSWWLLTLLFSLARPFTKSMQQGAATTVYCAVAPELEGIGGMYFNNCFRCLPSPQAQDPAAALSLWELSERLVQERSTPPQVL
What is the function of this protein?
Putative oxidoreductase.  Acts as a tumor suppressor and plays a role in apoptosis.  May function synergistically with p53/TP53 to control genotoxic stress-induced cell death.  Plays a role in TGFB1 signaling and TGFB1-mediated cell death.  May also play a role in tumor necrosis factor (TNF)-mediated cell death.  Required for normal bone development.  Inhibits Wnt signaling (By similarity).
What are the official names of this protein?
WW domain-containing oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HIS8_MYCMM
Sequence: MTSAPRPRPTLDDLPLREDLRGKSPYGAPQLAVPVRLNTNENPHPPTQALVDDVVRSVGEAAVDLHRYPDRDAVALRTDLANYLTAQTGTRIGFENVWAANGSNEILQQLLQAFGGPGRTAIGFVPSYSMHPIISDGTHTEWVETARADGFGLDIDAAIAVVSDRRPDVVFITSPNNPTGQSVSLTELRRLLDVVPGILIVDEAYGEFSSQPSAVGLIEEYPTRLVVTRTMSKAFAFAGGRLGYLVATPALIDALLLVRLPYHLSSVTQVAARAALRHAQDTLGSVATLIAERERVSKKLAGMGFRVIPSDANFVLFGEFADAPAAWQRYLDQGVLIRDVGIPGYLRATTGLADENDAFLRASARIAATDLAPAAASPVGAP
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: ERA_CLOTE
Sequence: MFKSGFITVIGRPNVGKSTLLNNIMKEKLSIVSHKPQTTRNNIQTILTQEDCQIVFVDTPGMHKPKHKLGEYMVKVAEEALKGVDIVLFMTTPEGQLGRGDVYILEQLKRIKQPVFLIVNKIDENDQGKVAETLKNYHDAYPFFKEIIPISASKDKNVDTLLELMKKYLPEGPKYYPEDMITDQQERFIVAEIIREKALRLLSEEVPHGIAVEMMTMKKNEKGNYEINATMLCERDSHKGIIIGKNGSMLKKISQYARQDIEKFLQSKVSLKVWVKVKKEWRDDNRILKELGYRQ
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: PYRH_ENT38
Sequence: MATNAKPVYKRILLKLSGEALQGTEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDNYSWAEAISLLRNNRVVILSAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVFTADPAKDPSATMYEQLSYNEVLDQELKVMDLAAFTLARDHKLPIRVFNMNKPGALRRVVMGEKEGTLITE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_EDWI9
Sequence: MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCGPVEVEQIKGKKITVVPILRAGLGMMEGVLEHVPSARISVVGIYRNEETLEPVPYFQKLVSHIDERMALVVDPMLATGGSMIATIDLLKNAGCRAIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNDKGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: FLIA_ECO57
Sequence: MNSLYTAEGVMDKHSLWQRYVPLVRHEALRLQVRLPASVELDDLLQAGGIGLLNAVERYDALQGTAFTTYAVQRIRGAMLDELRSRDWVPRSVRRNAREVAQAIGQLEQELGRNATETEVAERLGIDIADYRQMLLDTNNSQLFSYDEWREEHGDSIELVTDDHQRENPLQQLLDSNLRQRVMEAIETLPEREKLVLTLYYQEELNLKEIGAVLEVGESRVSQLHSQAIKRLRTKLGKL
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor controls the expression of flagella-related genes.
What are the official names of this protein?
RNA polymerase sigma factor FliA, RNA polymerase sigma factor for flagellar operon, Sigma F, Sigma-28.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. FliA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AC4CH_ECODH
Sequence: MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELKKVIADIYPGQTQFYVIEFKCL
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: RL16_PECCP
Sequence: MLQPKRTKFRKVHKGRNRGLAQGTDVSFGTFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLEVRMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFQLAAAKLPIKTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: ISPG_MYCTA
Sequence: MTVGLGMPQPPAPTLAPRRATRQLMVGNVGVGSDHPVSVQSMCTTKTHDVNSTLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPVVADIHFQPRYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPIRIGVNAGSLDKRFMEKYGKATPEALVESALWEASLFEEHGFGDIKISVKHNDPVVMVAAYELLAARCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPVEEVKVGNQVLESLNLRPRSLEIVSCPSCGRAQVDVYTLANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVRGEVIKTVPEAQIVETLIEEAMRLAAEMGEQDPGATPSGSPIVTVS
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: HOOK1_HUMAN
Sequence: MEETQPPPQPKLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEKLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSVKVPATTSD
What is the function of this protein?
Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997).  The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622).  FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997).  Required for spermatid differentiation.  Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity).
What are the official names of this protein?
Protein Hook homolog 1, h-hook1, hHK1.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria (By similarity). Often found in close association with microtubules (By similarity). Does not associate with the Golgi complex. During spermiogenesis, it localizes to the manchette in spermatids from steps 8-10. It is also present between the microtubule manchette and the nucleus. During manchette elongation, it is preferentially localized to the nuclear ring of the manchette, whereas the strong localization to the manchette decreases. In more mature spermatids, while the manchette migrates posteriorly, it localizes to punctuates spots. At later stages of spermatid differentiation, the punctuate expression pattern is found at both the attachment site and the proximal end of the elongated manchette. In contrast, it is not present in mature spermatozoa (By similarity).
Protein: SYT_YERPY
Sequence: MPVITLPDGSQRHYDHAVSVLDVALDIGPGLAKACIAGRVNGELVDASDLIESDAQLAIITAKDAEGLEILRHSCAHLLGHAIKQLWPDTKMAIGPVIDNGFYYDVDIEHTLTQEDLALLEKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAILDENISRDDRPGLYHHEEYVDMCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWGDKKQLNAYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYAEHMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGALHGLMRVRGFTQDDAHVFCTEEQVRDEVNSCIKMVYDMYSTFGFEKIVVKLSTRPEKRIGSDELWTRAEDDLAAALTENGIPFDYQPGEGAFYGPKIEFTLHDCLDRAWQCGTVQLDFSLPGRLSASYIGENNDRQVPVMIHRAILGSMERFIGILTEEYAGFFPTWLAPVQVVVMNITDSQSDYVQQVTKKLQDAGIRAKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKIAVRTRRGKDLGSLDVNVVVDQLLAEIRSRSLHQLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PK2_DICDI
Sequence: MGKGQSKIKNGGSGKPAKAGKPKKGNKNDETTPTSTPTPTPTPTQQNLDNSAQQQQQQQQTTTAAVSLDNKEQQQQQNIPAPATQTPITQTGTPTIEESQKNTDNNNINGASNEASSSPDSPNGSGNGNDDEDEGPEEVIFSKNKQSATKDDFELLNVIGKGSFGKVMQVKKKGEDKIFAMKVLRKDAIIARKQVNHTKSEKTILQCISHPFIVNLHYAFQTKDKLYMVLDFVNGGELFFHLKREGRFSEPRVKIYAAEIVSALDHLHKQDIVYRDLKPENILLDSEGHICITDFGLSKKIETTDGTFTFCGTPEYLAPEVLNGHGHGCAVDWWSLGTLLYEMLTGLPPFYSQNVSTMYQKILNGELKIPTYISPEAKSLLEGLLTREVDKRLGTKGGGEVKQHPWFKNIDWEKLDRKEVEVHFKPKVKSGTDISQIDPVFTQERPMDSLVETSALGDAMGKDTSFEGFTYVADSILKD
What is the function of this protein?
Required for morphogenesis during multicellular development.  Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ.
What are the official names of this protein?
Protein kinase 2, PK2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Persistently localized on the cell membrane.
Protein: NTF3_XENLA
Sequence: MSILFYVMFLPYLCGIHATNMDKRNLPENSMNSLFIKLIQADLLKNKISKQTVDTKENHQSTIPKPQILLDLDGDDNMKQDFQPVISLEAELVKQQKQRRYKSPRVLLSDSLPLEPPPLYLMDDYIGHSTVVNNRTSRRKRFAEHKGHRGEYSVCDSESLWVTDKMNAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKMVGWRWIRIDTSCVCALSRKIGRS
What is the function of this protein?
Seems to promote the survival of visceral and proprioceptive sensory neurons.
What are the official names of this protein?
Neurotrophin-3, NT-3, HDNF, Nerve growth factor 2, NGF-2, Neurotrophic factor.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.