PharMolix/UniProtQA huggingface dataset:
Protein: NS1_I43A0
Sequence: MDPNTVSSFQVDCFLWHVRKRVADQKLGDAPFLDRLRRDQKSLRGRGSTLGLNIETATRAGKQIVERILKEESDMPSAPASRYLTDMTIEEMSRDWFMLMPKQKVAGPLCIRMDQAIMDKSIILKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTNEDVKNAIGVLIGGLEWNDNTVRVSKTLQRFAWRSSNENGRPPLTPKQKRKMARTIRSEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: M3K6_HUMAN
Sequence: MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIRRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGDSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPVTSGP
What is the function of this protein?
Component of a protein kinase signal transduction cascade.  Activates the JNK, but not ERK or p38 kinase pathways.
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 6, Apoptosis signal-regulating kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Protein: RL11_BRUA4
Sequence: MAKKIAGQLKLQVAAGAANPSPPIGPALGQRGINIMEFCKAFNAASQEMEKGSPIPVVITYYQDKSFTFVMKTPPVTYFLKKAANLKSGSKTPGKASAGTISRDKVRTIAEAKMKDLNAADIEAAMRMIEGSARSMGLEVVG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RF1_SHEPA
Sequence: MKDSVIRKLEGLLERNEEVLALLSDAGVIADQERFRALSKEYSQLEDVVSTFKSFQQAEEDLESAKEMMEEDDPELKEMAQEEYKVAKSAIAALEDELQILLLPKDPNDDNNCFIEIRAGAGGDEAAIFAGDLFRMYSRYAESKRWQIEVMNTNEGEHGGFKEVIAKISGEGVYGKLKFESGGHRVQRVPETESQGRVHTSACTVIVLPEVPEAEAIEINKADLKVDTFRASGAGGQHVNKTDSAIRITHIPTGIVVECQDQRSQHKNRAQAMSVLAARIQAVEDEKRRSAEESTRRNLVSSGDRSERIRTYNFPQGRVSEHRINLTLYRLGEFMEGDIDCVVEPLIQENQADMLAALGEG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEP_I66A1
Sequence: MDSNTVSSFQDILMRMSKMQLGSSSEDLNGMITQFESLKLYRDSLGKAVMRMGDLHSLQNRNGKWREQLSQKFEEIRWLIEEVRHRLKVTENSFEQITFMQALQLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: EFTU_OENOB
Sequence: MAEKEHYERTKPHVNIGTIGHVDHGKTTLTAAITKVLSEKGLAQAQDYASIDAAPEERERGITINTAHVEYETDKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVNYIVVFLNKTDLVDDPELIDLVEMEVRELLSEYDFPGDDIPIIRGSALKALQGDPEQEKVILHLMDVIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVASGRIDRGTVKINDPVEIVGLKDEVKNTVVTGVEMFRKTLDLGEAGDNIGALLRGIDRDGVERGQVLAKPGSIQTHKKFKGEVYILTKEEGGRHTPFFTNYRPQFYFHTTDVTGVVELPEGVEMVMPGDHVTFTVELMKPVAIEKGLKFTIREGGHTVGAGTVSEIDD
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INSH3_ECOLI
Sequence: MSHQLTFADSEFSSKRRQTRKEIFLSRMEQILPWQNMVEVIEPFYPKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDSALPDRTTIMNFRHLLEQHQLARQLFKTINRWLAEAGVMMTQGTLVDATIIEAPSSTKNKEQQRDPEMHQTKKGNQWHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAEVDVDWLIAERPGKVRTLKQHPRKNKTAINIEYMKASIRARVEHPFRIIKRQFGFVKARYKGLLKNDNQLAMLFTLANLFRADQMIRQWERSH
What is the function of this protein?
Involved in the transposition of the insertion sequence IS5.
What are the official names of this protein?
Transposase InsH for insertion sequence element IS5D.
What is the protein family that this protein belongs to?
Belongs to the transposase 11 family.
Protein: YRAN_BACSU
Sequence: MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFGIELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFAQYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLTREKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQETCKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKAFIDFLKGEQMVTI
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YraN.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: BUR1_EMENI
Sequence: MGIASLERDTKGGTRFTGCTSIREFEFLGKLGEGTFGEVYKARAKRDGSIVALKKILMHNERDGFPITALREIKLLKMLSHTNIMQLREMAVERSKGEGRKKPSMYMVFPYMEHDLSGLLENPEVHFSEAQIKCYMIQLLEGLKYLHGNCILHRDMKAANLLISNQGILQIADFGLARPFDEAPPQPGKGAGEAKRDYTTLVVTRWYRPPELLLQLRRYTSAIDMWGVGCVFGEMFKGKPILAGNSDLNQAQLIFSLVGTPTEENMPGWSSLPGCEGVKHFGNRPGNLAEVFKDQGPMAISLLTELLKLDWRKRVNAIDALKHPYFSTPPLPARPGDLPSFEDSHELDRRRFRGQRAAMPPAPAGGSVGMSRNGGWSTNSGSRTGAETRNPRISSAARSQGNQLRDAWSNEPQQAWQRRGNEELKDPNHSFSSRHRDGGLPPKPPAPIQHSWASGHSDKTGRDRGYGARYGGPEGSVDSYVPNYGGSDRNRDRDQGTAISDRRGSYYDKSHQTSKLDYSREIPSRRRSRSPNYRERVDRGPYRR
What is the function of this protein?
Serine/threonine-protein kinase involved in transcription regulation.  Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes.  Also required for histone H3 methylation.  Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase bur1, PITALRE-like kinase A.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: EBPS_STAS1
Sequence: MSNNNFKDDFEKNRQSIDPKEHQENTQDSVNDSVDNIKEEVSDKSDEQFPPRNAQRRQRRRDTATNQREDEQSNQEHHNENNEVGDRDNGLQHEDNSSRDSNADKESNDPSQNNNLIHESSNNQQSENRHDINNEKDQSDKDSNNKKGAVIASSGAAGVGAYAASKHNDAASSSKDHNDKAHQQNQDWEQSNQTNDSTETQDENTNNHDSKKKGAAVAGGAAAAGAGAYAAGKHKGKKDKNDNEPEQNESKSDVKNEEKHGSKKKGAAVAGGAAAAGTGAAAASHSKSSTGNGGNGNGGNGGNGNNGDNNHDSEDNNKKKGGLLGKLLPIIAAILILAAIGIFGGMALTGNNDDKGSDDDKKVADNKDKDSDKAKDADSDKDSKSDKDKDKAKDDDNNQATTDSDSSDSSDNANSDSDQGNNDSQDQANSDQNQGTQDEQNSQNNQDQQSDQSQQNGQANSNQNGSSDQSQNASNDSNQQNNQSSNSNSGQRTHVVNGQNLYRIAIQYYGEGTPENVEKIREANNIQGNDIHNGQRLVIPQ
What are the official names of this protein?
Probable elastin-binding protein EbpS.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RPOZ_SHEON
Sequence: MARVTVEDAVEQIGNRFDMILVAARRARQIAVQGKDPMVEEMNDKPTVIALREIELGLVNAHTLDADERQTVREREAAEIAAVAAIAEGRSL
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: SNX3_GIBZE
Sequence: MASDQDNSGLDAPGSQFHRPILQSMPDTRQQSFDEIYGPPENFLEIEVRNPRTHGMGRHMYTDYEILCRTNIPAFKLRQSSVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDDVIEGRRAGLEKFLKIVVGHPLLQTGSKVLAAFVQDPNWDRNAW
What is the function of this protein?
Required for retention of late Golgi membrane proteins.  Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment.  Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
What are the official names of this protein?
Sorting nexin-3.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Prevacuolar compartment membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RP147_VARV
Sequence: MAVISKVTYSLYDQKEINATDIIISHVKNDDDIGTVKDGRLGAMDGALCKTCGKTELECFGHWGKVSIYKTHIVKPEFISEIIRLLNHICIHCGLLRSREPYSNDINLKELSGHALRRLKDKILSKKKSCWNSECMQPYQKISFSKKKVCFVNKLDDINVPNSLIYQKLISIHEKFWPLLEIYQYPANLFYTDYFPIPPLIIRPAISFWIDSIPKETNELTYLLGMIVKNCNLNADEQVIQKAVIEYDDIKIISNNTTSINLSYITSGKNNMIRSYIVARRKDQTARSVIGPSTSITVNEVGMPAYIRNTLTEKIFVNAFTVNKVKQLLASNQVKFYFNKRLNQLTRIRQGKFIKNKIHLLPGDWVEVAVQEYTSIIFGRQPSLHRYNVIASSIRATEGDTIKISPGIANSQNADFDGDEEWMILEQNPKAVVEQSILMYPTTLLKHDIHGAPVYGSIQDEIVAAYSLFRIQDLCLDEVLNILGKYGREFDPKGKCKFSGKDIYTYLIGEKINYPGLLKDGEIIANDVDSNFVVAMRHLSLAGLLSDHKSNVEGINFIIKSSYVFKRYLSIYGFGVTFKDLRPNSTFTNKLEAINVEKIELIKEAYAKYLKDVRDGKIVPLSKALEADYVESMLSNLTNLNIREIEEHMRQTLIDNPDNNLLKMAKAGYKVNPTELMYILGTYGQQRIDGEPAETRVLGRVLPYYLPDSKDPEGRGYILNSLTKGLTGSQYYFSMLVARSQSTDIVCETSRTGTLARKIIKKMEDMVVDGYGQVVIGNTLIKYAANYTKILGSVCKPVDLIYPDESMTWYLEISALWNKIKQGFVYSQKQKLAKKTLAPFNFLVFVKPTTEDNAIKVKDLYDMIHNVIDDVREKYFFTVSNIDFMEYIFLTHLNPSRIRITKETAITIFEKFYEKLNYTLGGGTPIGIISAQVLSEKFTQQALSSFHTTEKSGAVKQKLGFNEFNNLTNLSKNKTEIITLVSDDISKLQSVKINFEFVCLGELNPNITLRKETDRYVVDIIVNRLYIKRAEITELVVEYMIERFISFSVIVKEWGMETFIEDEDNIRFTVYLNFVEPEELNLSKFMMVLPGAANKGKISKFKIPISDYTGYDDFNQTKKLNKMTVELMNLKELGSFDLENVNVYPGVWNTYDIFGIEAARGYLCEAMLNTYGEGFDYLYQPCDLLASLLCASYEPESVNKFKFGAASTLKRATFGDNKALLNAALHKKSEPINDNSSCHFFSKVPNIGTGYYKYFIDLGLLMRMERKLSDKISSQKIKEMEETEDF
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG133, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase 147 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 147 kDa subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle (By similarity).
Protein: GHT2_SCHPO
Sequence: MGFKRGKNFTLVMLIFVSMAGWMFGADTGSIGGVTSMRDFRERYADRYDPITDQYSLSSARQGLLTGMVNVGSLFGCIISSPIADRFGKRLSIIGFCAVYIIGIIVQVTAVPSWVQIMVAKIWTGIGIGALSVLAPGYQSETAPPSIRGTVVVTYQLFVTGGIFIAACINMGTHKLHKTAQWRVSIGINLLWGIITMIGILFLPESPRYLIQVGKDEEAVRVLSESAELFPDSEEVQNEYHRLKSSIDEEFAGGPCSWASIFGKDIRYRTFLGMFVMSLQQLTGNNYFFYYGFSVMQGAGINSPYLSAMILDAVNFGCTFGGMYVLERFGRRNPLIIGGIWQSICFFIYSAVGSRALYHKNGTSNTRAGAVMIVMACLFIFGFAQTWAPAAYVIVGESYPVRYRSKCAAVATASNWLWNFLISFFTPFIQASIGFKYGYVFASCNLTGAIVIFLFAKETKGLTLEEINELYMSVIKPWESGNFKLNYSEQKKVEKEKSRKGGARGESVEYVERASNTDSSPQYSSHEEDYA
What is the function of this protein?
High-affinity glucose transporter.
What are the official names of this protein?
High-affinity glucose transporter ght2, Hexose transporter 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TA2R5_PANTR
Sequence: MLSAGLGLLMLVAVVEFLIGLIGNGVLVVWSFREWIRKFSWSSYNLIILGLAGCRFVLQWLIILDLSLFPLFQSSRWLRYLSIFWVLVSQASLWFATFLSVFYCKKITTFDHPAYLWLKQRAYNLSLWCLLGYFIINLLLTVQIGLMFYHPPQGNSSIRYPFESWQYLYAFRLNSGSYLPLMVFLVSSGMLIVSLYTHHKKMKVHSAGRRDVRAKAHITALKSLGCFLLLHLVYIMASPFSIASKTYPPDLTSVFIWETLMAAYPSLHSLILIMGIPRVKQTCQKIXWKTVCARRCWGP
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 5, T2R5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ATG2_ASPTN
Sequence: MAYFLPSFFQKRLLRYALSRLELVDTEALDLDSLGIRWGQRSTVELRDIGLRLEKLSTLLRLPPSSELLSARIRLLRLTVPADIYSSGIIFQTSGIDVHLRLPLNDVSADQDTHRSPTDDTGDDHVLPNPTDLAESFLQAEPKEEKEELQAAISSQSQVLQHTSTSSSDDEEEFGLGEEAVSLPSFVAGFLKGVVERLQVEVEDVSIRVDVETKQDGPSKRQPEEKPDLVTGLISVRQINVGAVSKSHDSEEGILRWGKRQISVSDVNLALISDPIVFSNYSRFTAPPLSPSTPVQSRPSQPPSEVMSPSPELNPSDSNPGLGMTQSTIFAPPQSDDEPVPEAPHELEMAGSVYTYDGRFSDADTEETRSYGHLGDSQNFSDDDKLLDNPDYLDSVIDSHLHDEDLERSVNLPRDDAPSAREEDTPRLHDSSTFNFEPTMAHHTLQEVSSPTIHGQVLEDRTGSFGSASLGRDASSEHSLPEDSLSENQHAEEPQHEVRAHMSGSQPAPPSEEGSSSSTSNSFRDGDLSESKIYSHEEAQSMYMSAISHGSTSRSFVPNIPGAWDSPGSTATRYFDVHNRSQCSGDTNRTRDEKDETTAATPRLHAQAGSHIPQEYPLDGSRTAHSEATDKGSFESTQGLNKLNDIAKRFLTIDKMSIWVPSRDGTDEPSGAVSEMSFSHGGVDPNVSGHSERRSYPKRSQDETAIELHSAEIHFDISTGWLLAKVGQRVVDAFAHNDSETPKKSRSQQDSHSDQAISLSFGKFSIKFVEHIPGHAYPPEDSRIHSPTYFGLMHEDVLLQTTVAGLQAHYSETGNATKLRLELAKFTLGFASEDLISFSEDLKMRESVRDVLSPVHGDVSLSLTKSADSARVNIATLPLQVNINVQRLEDVLGWIGGLSTILELGNSIPSVSGVKAQKEPPKRSRGVHFEPSPPPVKESRQPSIPWKVDSRIGGMALDVVGETHYLKLRTTAVKVVSRQKGIAVQIDKAKLSGPLSLEGTRDAPAKVNFTNIRVEFLFSPDDDDLDRLLSLITPSKDKYDEDDDIMLDTLLRQRRQGSILRATVDGARVAISRIQDLEHLSQLGDELGKLSNVTKYLPEDDRPGILSLALVRDFEARMHVGGQVGDITVRLKEAETAYISIPSLVAARLGSMTVVRNEIEELVGEALPLHMAQAQHPMLMARFIADEMEPTIKVKVYNLRAEYTVPSMVAFLGLSDDMTAGKVAENMTSSLVNLADLPPPHISPVSGGHESPRGPVKPIKLAVVLRDSVIGLNPRGTAAKGLLVLTNAKFSGAIHDPASSEATLDLRKASVMVIDDVQNIGITDNPRQGRWTTPQSDQVHSFIEMGFVPISSISSATATIRIMQLSEDGTKSLDVEFRDDLLILETCADSTQTLISIVNGLQPPTPPSVAVKYRTEVLPIQDMLASFSGDAFATDAASPEHAAEGSSDLAQPANTKGNQIEDELEYVSDFYPVKPGSENASLHENLAGSGSNELLDSFHSQYYMSSSVSELDFRDDHFAKQSAVGGTAHRWDSTQNTYGLSDDSKLQKSPLRIRVRDAHVIWNLFDGYDWQRTRDTISKAVKDVEKRATEKRARVGNRASPGFDDDEESVIGDCLFNSIYIGIPANKDPRELRQDINRGIDDLASETGSYATTTTVTGATARQNHSPPFKKKLRLSRSKYHKMTFELKGICADLVVFPPDSGETQSSLDVRIKDLEIFDHVPTSTWKKFATYMHEAGEKESGTSMVHLEVLTVRPVPELAASEIVLKATILPLRLHVDQDALDFLSRFFEFRDDSAPASPSPQDIPFLQRVEVNSIPVKLDFKPKRVDYAGLQSGRTTEFMNFFVLDGADMVMRHVIIYGIAGFDKLGQTLNDIWMPDIKRNQLPSVLAGLAPIRSLVNVGGGVKDLVVVPMREYRKDGRIVRSIQKGAWSFAKTTSNELVKLGAKLAIGTQTVLQGAEEMLTSPNAPVPVSEEDSTDEEEAKKISLYADQPIGVVQGLRGAFRGLERDLLLARDAIVAVPGEIVESGSATAAAKAVWKRAPTVVLRPAIGVSKAVGQTLLGAGNTLDPSNRRKMEDKYKRH
What is the function of this protein?
Lipid transfer protein required for autophagosome completion and peroxisome degradation.  Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion.  Atg2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region.  The latter binding is assisted by an atg18-PtdIns3P interaction.  Atg2 then extracts phospholipids from the membrane source using its NR and transfers them to atg9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
What are the official names of this protein?
Autophagy-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the ATG2 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: CYB_POTTR
Sequence: MTNLRKTHPLIKIINHSFIDLPAPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFLHVGRGIYYGSYLYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIIVALVVVHLLFLHETGSSNPSGINPDSDKIPFHPYYTIKDILGLMIMLLTLLALALFSPDMLGDPDNFSPASPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLLIPLLHTSKQRSLMFRPISQTLFWMLTADLITLPWIGGQPVEQPFIIIGQVASILYFSLIIILMPLAGLLENYMLKPKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SIGA_MICAE
Sequence: MMQAHDVLTLTEPPLDLDLIDLDEDFDDEDIELELEETSDSNDGKKTRRLASARRRDAARKKPYTEDSIRIYLQEIGRIRLLRAEEEIELARKIADLLKLERIREDFCLYSDAEWGKQVFLFERIEKIIVEKSEKEPKLSDIKAYLGKTELTAPLLEEWLAKSKEYLSAFKRRLYHGRRAKEKMVQSNLRLVVSIAKKYMNRGLSFQDLIQEGSLGLIRAAEKFDHEKGYKFSTYATWWIRQAITRAIADQSRTIRLPVHLYETISRIKKTTKILSQEMRRKPTEEEIATKMEMTIEKLRFIAKSAQLPISLETPIGKEEDSRLGDFIEADGETPEDEVSKNLLREDLENVLDTLSPRERDVLRLRYGLDDGRMKTLEEIGQIFNVTRERIRQIEAKALRKLRHPNRNSILKEYIR
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_BURM9
Sequence: MSEKTVKVQLVKSLIGTRESHRATVRGLGLRRLNSVSELQDTPAVRGMINKVSYLVKVIG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: LPXH_PSEF5
Sequence: MILLISDLHLEEERPDITRAFLELLGGRARAAEALYILGDFFEVWIGDDAMTPYQLSICQALRELSDSGTQIFLMHGNRDFMLGKAFCKAAGATLLKDPSVVDFYGEPVLLMHGDSLCTRDEAYMRMRRYLRNPLSLWILRHLPLGTRRKLARKLRNESRAQTRMKANDIVDVTPDQVPQVMQEHGVRTLVHGHTHRPAIHKLQIGEQAAKRIVLGDWDRQGWALQVDEQGFQLAAFDFVPTQLALPGSP
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MURD_DECAR
Sequence: MELKGKRVLVVGLGESGLAMAKWLHRQGALVRVADSRDNPPNIDALQRVAPGAELVAGAFAEATFAGADFVALSPGVPKATPEIAALEIPLISEIELFADGVREQVPNSQIIAITGSNGKTTTTALTAHLLNGAGVPAIACGNISPSALDALMDAQDAGALPQVWVVELSSFQLETTHHLNAAAATVLNVSEDHLDRYEGSLANYAAAKSRVFQGKGVMVLNRDDDWSMANGRCGRKMVTFGLNAAPRGVDYGYADGAIWRGKDKLVAIDALKLSGLHNAANAMAALALCEAIGVDPLRLIEPLKGFSGLPHRVETVAEIGGVLYVDDSKGTNVGATLAAIEGMGRKVAIVLGGDGKGQDFSPLKPALEKHGRAVALIGRDAAAIGMALEGSGVPTRILGDMEAAVLWLAAQAQAGDCVLLSPACASLDMYRNYAHRAQAFIDAVEGLKS
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.