PharMolix/UniProtQA huggingface dataset:
Protein: QUEA_STAAR
Sequence: MNIEEFDYDLPESLIAQTPLKDRDHSRLLVMDRETGEMKHLHFKDIIEYFRPGDTLVLNDTRVMPARLFGLKEETGAKVEMLMLTQIEGNDWEVLLKPAKRIKVGNKLNFGNGKIIAECIKEMDQGGRIMRLHYEGILQERLDELGEMPLPPYIKERLDDPDRYQTVYAKESGSAAAPTAGLHFTDELLTEIKNKGVNIAFVTLHVGLGTFRPVSVDDVNDHEMHSEYYQMTQETADLLNDTKSKGHRIISVGTTSTRTLETIRRDHDKFVETSGWTNIFIYPGFDFKAIDGQITNFHLPKSTLVMLVSAFSTRENVLNAYKTAVNLEYRFFSFGDAMLII
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTWD2_MACFA
Sequence: MESQKEARILQEPVARPPGASRSQTPNAKERQEGGPVPAAAALGAEADDDSADRLWELPVEPAKRRPECSRCSRPQKVCLCPFLPAHPLHISTHLYIIQHPAEENKVLRTVPLLAACLPQDKCKVKIGRRFSEERDPELSTVCRKSGTLILYPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRHPKQVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPLQALCSFQLQHGAQIRLSKEHLLKNGLYTKPMPKNKRKLRKMELLMNSVKI
What is the function of this protein?
Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)).  Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)).
What are the official names of this protein?
tRNA-uridine aminocarboxypropyltransferase 2, DTW domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the TDD superfamily. DTWD2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MRAZ_ERWT9
Sequence: MFRGATLVNLDSKGRLAVPTRYREMLNEGSQGQMVCTIDLHQPCLLLYPLPEWEIIEQKLSRLSSMNPAERRVQRLLLGHASECQMDNAGRILLANTLRQQASLSKQVMLVGQFNKFELWDEQTWYQQVREDIDEERSSKQPLSERLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MOAC_CAUSK
Sequence: MTRLTHIDDQGRARMVDVSDKAETVREAIAVGFVRMTPETLALAITGAGRKGDVRAVAEIAGVMAAKKTADLIPLCHPLALSKVEVSVEVAEGGLAVMARVKLKGQTGVEMEALTAVSVACLTIYDMLKAAEKGMVIETVRLVEKTGGKSGAWRAE
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: RISB_CARHZ
Sequence: MQVFEGKLNGKGLKIGIIVSRFNEFITQKLLAGALDCLTRHEVENTNIDVIWVPGAFEIPLVAKRAVHKDYDAIICLGAVIRGATPHFDYVAAEVAKGIAAVGLEANKPVIFGVLTTDTIEQAIERAGTKAGNKGWEAALAAIEMANLFKKV
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: POC2_YEAST
Sequence: MSCLVLPLVSVGNIPQLSIDWLLNSQANEWEYLEALDSKYLVEFVGPLDRPEDGSDSLYKDADMKYSSALEVFYNKKRGLFAIQQRTPLVSVNYLNNFIVEIILPFLSKYNISEICIWDSLYAMEDENGVIVRPQEVYSLGEFYFDDEAELLSNLHLNDQESMVNNWLHFTPTSFQDKISVDQPIFKILFQILNASQRPKALRSIKYCSCLANEGDNSLDSQQFLQWIISQKVIKNAPPIVKFVRPISWQGAYGMADARDKFVDLYN
What is the function of this protein?
Involved in 20S proteasome assembly.  Required for maximal proteasome activity.  Affects the chymotrypsin-like activity of the proteasome.  Can be degraded by the proteasome.  Involved in the endoplasmic reticulum-associated degradation (ERAD).
What are the official names of this protein?
Proteasome assembly chaperone 2, Alpha-1-proteinase inhibitor-degradation deficient protein 66, Proteasome biogenesis-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the PSMG2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_MINFU
Sequence: MTNIRKSHPLIKIVNSSLVDLPAPSNISSWWNFGSLLGVCLGIQILTGLFLAMHYTADTATAFNSVTHICRDVNYGWILRYLHANGASMFFICLYLHVGRGLYYGSYTLTETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGTDLVEWIWGGFSVDKATLTRFFAFHFLLPFIIAAMVMVHLLFLHETGSNNPTGIPSDMDAIPFHPYYTIKDALGFLVMIMMLLTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILVLAIVPLLHTSKQRSMTFRPISQCLFWLLVANLLTLTWIGGQPVEHPYIIIGQLASILYFMIILVLMPLISIMENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FADB_ECO57
Sequence: MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGEAIGVLEQQSDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTIAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRMPRMLGADSALEIIAAGKDVGADQALKIGLVDGVVKAEKLIEGAMAILRQAINGDLDWKAKRQPKLEPLKLSKIEATMSFTIAKGMVAQTAGKHYPAPITAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDVETPKQAAVLGAGIMGGGIAYQSAWKGVPVIMKDINDKSLALGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFERVDVVVEAIVENPKVKKAVLAETEQKVRPDTVLASNTSTIPISELANALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKDYRDAIDALFDANRFGQKNGLGFWHYKEDSKGKPKKEEDAAVDDLLAEVSQPKRDFSEEEIIARMMIPMVNEVVRCLEEGIIATPAEADMALVYGLGFPPFHGGAFRWLDTLGSAKYLDMAQQYQHLGPLYEVPEGLRNKARHNEPYYPPVEPARPVGDLKTA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: PYRF_PICST
Sequence: MVNVQTYTQRAESHQSPVAQRLFKLMDSKKTNLCASVDVKTTSEFLSLIDKLGPYICLVKTHIDIIDDFSYEGTIVPLLELSKKHNFMIFEDRKFADIGNTVKSQYSGGVYKIAQWSDITNAHGVTGSGIVQGLKEAARETTDEPRGLLMLAELSSKGSIAHGKYTEETVEIAKTDKEFVIGFIAQRDMGGQDEGFDWIVMTPGVGLDDKGDSLGQQYRTVDEVVSTGTDIIIVGRGLFGKGRDPDVEGQRYREAGWNAYLKKTSQV
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase, Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family.
Protein: ATPI_CALFG
Sequence: MNVLPCSINTLKGLYDISEVEVGQHFYWQIGGFQVHAQVLITSWVVIAILLGSAAIAVRNPQTIPTDGQNFFEYVLEFIRDLTKTQIGEEYGPWVPFIGTMFLFIFVSNWSGALLPRKIIQLPHGELAAPTNDINTTVALALLTSVAYFYAGLTKKGLGYFGKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: LCYB_SOLLC
Sequence: MDTLLKTPNNLEFLNPHHGFAVKASTFRSEKHHNFGSRKFCETLGRSVCVKGSSSALLELVPETKKENLDFELPMYDPSKGVVVDLAVVGGGPAGLAVAQQVSEAGLSVCSIDPNPKLIWPNNYGVWVDEFEAMDLLDCLDATWSGAAVYIDDNTAKDLHRPYGRVNRKQLKSKMMQKCIMNGVKFHQAKVIKVIHEESKSMLICNDGITIQATVVLDATGFSRSLVQYDKPYNPGYQVAYGILAEVEEHPFDVNKMVFMDWRDSHLKNNTDLKERNSRIPTFLYAMPFSSNRIFLEETSLVARPGLRIDDIQERMVARLNHLGIKVKSIEEDEHCLIPMGGPLPVLPQRVVGIGGTAGMVHPSTGYMVARTLAAAPVVANAIIQYLGSERSHSGNELSTAVWKDLWPIERRRQREFFCFGMDILLKLDLPATRRFFDAFFDLEPRYWHGFLSSRLFLPELIVFGLSLFSHASNTSRFEIMTKGTVPLVNMINNLLQDKE
What is the function of this protein?
Catalyzes the double cyclization reaction which converts lycopene to beta-carotene and neurosporene to beta-zeacarotene.
What are the official names of this protein?
Lycopene beta cyclase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the lycopene cyclase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DBP9_ASPNC
Sequence: MKRKLDANDVPSPEVAETKETSDADEADFESLNLDPRLRQALIKEKFTKPTPVQAKAIPLALAGKDILARAKTGSGKTAAYVLPILQTILQKKAADPSLKATTGLILVPTRELAEQVQKVVTTFAAFCGKDVRSVNLTQKVSEAVQRTMLSDYPDIVISTPARVIANLGNSSLSLDNLTHLVIDEADLVLSYGYDEDINALSKAIPRGVQTFLMSATLTSEVDTLKGLFCRSPVVLKLEDKEEKGAGVSQFVVKCAEDEKFLLTYVIFKLQLIKGKVIIFVGDIDRCYRLKLFLEQFGVKSCVLNSELPVNSRIHVVQEFNKGVYDIIIAADDQEVLGSKSKKAKNAGADEEEEAAGVMGSSDDEEAEDDKKSNRPDKRRKLTAKEKDYGISRGIDFQNVACVLNFDLPTTAKSYTHRIGRTGRGGKTGMALSFVVPADQYGKHKPTSFPTAKHDEAVLAKIVKRQSKHGHEVKPYHFEMSQVDAFRYRMTDGLRAITRLAVQEARAREIRQELVKSEKLKRHFEDNPDELRQLRHDGELRSARIQPHLKHIPEYLMPSKGRKGISSEDVGFVGFRKSSDNRIRKARDKNRAKGKGRKPSGVRKVDPLKTFNRGRK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase dbp9.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: FUMC_RICPR
Sequence: MKNYRIESDSFGEIQIEEKFYWGAQTQRSLNNFKISKQKMPKILIRALAILKKCAAQVNYEFGDLEYKIATSIDKAIDRILAGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTGKKGGKFPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQLIPALNNLLTYLQDKSKDWDKIIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIEDALKKVYLLAQGGTAVGTGINSKIGFDIKFAQKVAEFTQQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIANDIRLLGSGPRCGLGELHLPENEPGSSIMPGKVNPTQVEALTMVCTQVMGNHVTVTIAGSNGHLELNVFKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARINTLRDKSLMLVTVLNPHIGYDNAAKIAKEAHKYGITLKEAAKKLNFLSEEEFDKIVVPEKMIS
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSSA_DROMO
Sequence: MSGGLDILSLKEDDITKMLVATTHLGSENVNFQMEQYVFKRRADGVNIINLGKTWEKLVLAARAIVAIENASDVFVISSRPIGQRAVLKFAKYTDTTPIAGRFTPGAFTNQIQPAFREPRLLVVTDPNTDHQPIMEASYVNIPVIAFTNTDSPLRYIDIAIPCNNKSPHSIGLMWWLLAREVLRLRGTISRTTEWPVVVDLFFYRDPEEAEKEEAAAAKELLPPPKIEEAVDHPVEETTNWADEVAAETVGGVEDWNEDTVKTSWGSDGQF
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.  Required during oogenesis and imaginal development.
What are the official names of this protein?
40S ribosomal protein SA, Protein stubarista.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=May associate with nascent RNP complexes within the nucleus.
Protein: NADK_PROA2
Sequence: MKFAIVVNINREDALELAQELTSWLQERGLSYVLDSVSGEKTGIEPSMAMEELNKDCDAFISLGGDGTLLFTSHYSVTKPVIGINVGHLGFLAEFSKAEMFEAVEQVLNGTYSIHVRSQLEAEVTMNGGLKHLTALNDVVIEKGAYPRIPTFIIKLDDELLSAYRADGIIIATSTGSTAYSLSAGGPIIAPKSNVFVITPICPHMLTVRPIVISDDKTIQISVEAHGGEFPLNCDGHVSKMLLPGETIIVRKSEQIINLVENKNRRYCEILRSKLLWGHEHQSGS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLCR_PSEAE
Sequence: MRPTLTWTLLALLLCGTAIGAVLLFYPSEPAPVAPFASPPQATPAAKPSIPSRAPEMNTATAPDNLEQQLGEFGRNAGQMSEIERKQAAEGLIEQLKREVAVGADPRQTFEEIQRLTPYVEADARRREALDFEIWMALKDNASVQQQAPTPGEEEQLREYAQESDKVIAEVLASVDDEEQRHAAIDERLKALRKQIFGEENPRLLQR
What is the function of this protein?
May be involved in the regulation of synthesis of phospholipase C.
What are the official names of this protein?
Phospholipase C accessory protein PlcR.
What are the subcellular locations of this protein?
[Isoform plcR1]: Periplasm. SUBCELLULAR LOCATION: [Isoform plcR2]: Cytoplasm.
Protein: RF1_BORPE
Sequence: MKPSMRSRLEQLAHRLIEVDALLAEPETAADMDRFRKLSRERAELEPVVEAFNAFLGVEADVATAQEMLSDPDMKAMAEDEIKTGRARIEEMEAALQLLLLPRDPDDGRSLFLEIRAGTGGDESALFSGDLLRMYTRYAETRGWRVEIMSESESELGGYKEVIARIDGDGAYGRLKFESGAHRVQRVPATEAQGRIHTSACTVAVMPEADAMSDIVINPSDLRIDTFRASGAGGQHINKTDSAVRITHVPTGLVVECQDDRSQHRNKDKAMQVLAARLKDKEMRERQSKEAAERKSLIGSGDRSERIRTYNYPQGRVTDHRINLTLYKLQQIMEGDLDELTGALLAEHQAEQLAALGHDL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCNNA_RABIT
Sequence: MKGDKREEQGPGPETVAPQQPTEDEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVNLNINLNSDKLVFPAVTVCTLNPYRYPEITEQLKELDSITQQTLLDLFKYNASTLEAQPRHRRDVHPPLPHPLQRLRVPPPRLEARRARSSASSVRDNSPEVGRKDWMIGFQLCNQNRSDCFYQRYSSGVDAVREWYRFHYINILSRLSDTSLSREQLGNFIFTCRFNQAFCGDGNYSHFHHPMYGNCYTFNDKNNSSLWMSSMPGINNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKESLDRLGGDYGDCTQNGSDVPVKNLYRSKYTQQVCIHSCFQENMVKECGCAYIFYPLPEGVEYCDYRKHNSWGYCYYKLQDAFSSDRLGCFTKCRKPCSVTNYELSAGYSRWPSVTSQDWVFQMLSLQNNYTVSNKRNGVAKLNIYFKELNYKANSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELLFDLSVITFLMLLRRFRSRYWSPGRGAGGAREVASSPVSALPSRFCPHPTSPSVPQPGPTLPPSLTAPPPAYATLGPCLSQSGSACAPGEP
What is the function of this protein?
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride.  Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells.  Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.  Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands.  Also plays a role in taste perception.
What are the official names of this protein?
Amiloride-sensitive sodium channel subunit alpha, Alpha-NaCH, Epithelial Na(+) channel subunit alpha, Alpha-ENaC, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA.
What is the protein family that this protein belongs to?
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cytoplasmic granule. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non- ciliated epithelial cells, restricted to apical surfaces. In epidermis, located nearly uniformly in the cytoplasm in a granular distribution. In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles. In eccrine sweat glands, mainly located at the apical surface of the cells facing the lumen. In skin, in arrector pili muscle cells and in adipocytes, located in the cytoplasm and colocalized with actin fibers. In spermatogonia, spermatocytes and round spermatids, located in the cytoplasm. Prior to spermiation, location shifts from the cytoplasm to the spermatid tail. In spermatozoa, localizes at the acrosome and the central region of the sperm flagellum.
Protein: LSRD_YERPG
Sequence: MNLYRRYGWELTLAALLVLEILLFGLSNSRMLDINVLLFSTSDFICIGIVALPLTMVIVSGGIDISFGSTIGLCAIFLGIVFQAGVPMSVAIPLTVLVGALCGLINAGLILYTGVNPLVITLGTLYLFGGSALLLSGLSGATGYEGIGGFPAAFTDFANQTLFGLPIPLVIFMLCVLLFWLLMHRTHSGRHVFLIGQSSRVARYSALPIARTLCMLYAMTGVASAISAILLVSYFGSARSDLGASFLMPAITAVVLGGANIYGGSGSILGTALAVLLVGYLQQGLQMIGTPNQISSALSGALLILVVVGRSISLHRHLIYEWLQRRRSRKASA
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Autoinducer 2 import system permease protein LsrD, AI-2 import system permease protein LsrD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EPPI_HUMAN
Sequence: MGSSGLLSLLVLFVLLANVQGPGLTDWLFPRRCPKIREECEFQERDVCTKDRQCQDNKKCCVFSCGKKCLDLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTCKNKRFP
What is the function of this protein?
Serine protease inhibitor that plays an essential role in male reproduction and fertility.  Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.
What are the official names of this protein?
Eppin, Cancer/testis antigen 71, CT71, Epididymal protease inhibitor, Protease inhibitor WAP7, Serine protease inhibitor-like with Kunitz and WAP domains 1, WAP four-disulfide core domain protein 7.
What are the subcellular locations of this protein?
[Isoform 1]: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.
Protein: COAD_ECOHS
Sequence: MQKRAIYPGTFDPITNGHIDIVTRATQMFDHVILAIAASPSKKPMFTLEERVALAQQATAHLGNVEVVGFSDLMANFARNQHATVLIRGLRAVADFEYEMQLAHMNRHLMPELESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPENVHQALMAKLA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAL1_MOUSE
Sequence: MTERPPSEAARSDPQLEGQDAAEARMAPPHLVLLNGVAKETSRAAPAEPPVIELGARSGAGGGPASGGGAARDLKGRDAVAAEARLRVPTTELCRPPGPAPAPAPASAPAELPGDGRMVQLSPPALAAPAGPGRALLYSLSQPLASLGSGFFGEPDAFPMFTNNNRVKRRPSPYEMEISDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQEEEGTQRAKPGKDPVVGAGGGGAGGGIPPEDLLQDVLSPNSSCGSSLDGAASPDSYTEEPTPKHTSRSLHPALLPAADGAGPR
What is the function of this protein?
Implicated in the genesis of hemopoietic malignancies.  It may play an important role in hemopoietic differentiation.  Serves as a positive regulator of erythroid differentiation.
What are the official names of this protein?
T-cell acute lymphocytic leukemia protein 1 homolog, TAL-1, Stem cell protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y051_RICCN
Sequence: MSASSLIKWVCYLGDIAASGFLNSIATALIAVLHDAGDNMFNSKEEKKLVDILTKFYKMINKQSDITVPVGQDLQRLALLFANLRSVEIKKNNETDFSNFFTTKLPMHNKFFRYDTK
What are the official names of this protein?
Uncharacterized protein RC0051.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CST11_MOUSE
Sequence: MAAGSWKATRLLLAILVALVAFSYQVKRKTFIRIEEVSALESSVKETLEYVTDEYNKKSEDLYNFRILRILKIMKQVTGHLEYHITVEMQRTTCLKTETSLCDIQKGELHKKIQCYFSVYAIPWVEVFKILKKNCTDIS
What is the function of this protein?
Has antibacterial activity against the Gram-negative bacteria E. coli.  May play a role in sperm maturation and fertilization.
What are the official names of this protein?
Cystatin-11, Cystatin-E1, Cystatin-related epididymal spermatogenic protein 2.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted into the epididymis lumen, where it localizes to the outer surface of sperm. Specifically localizes to the postacrosomal and tail regions of sperm.
Protein: ENO1_METHJ
Sequence: MVQIEKVFGREIIDSRGNPAVEVDITLVGGYFGRAACPSGASTGTHEAIEKRDGDFRFFGKGVKKAVEAINTDIRKSLLGMDSTDQPAVDNQLISLDGTDNKGHLGANAILPVSMAVARAASQALQVPLYEHLADRTYLLPVPYMNILNGGAHANWQGADFQEYMIAPVGAPDFPEAVRWGCEVYHTLKAILKKRGLSTGVGDEGGFAPKVSSNRAPLDFITEAIEMAGYKPGKDISLALDPASSEFYSDGVYELKSEGKKLSSEEMTGYYEDMVAVYPIISIEDGLSEDDWNGWIAMTKAIGKKVQLVGDDIFVTNTKRISRGISEKAANAVLIKLNQIGTVTETISAVTMARNAGWSSMISHRSGETVDSFIADLTVSLGTGQIKTGAPCRGERVEKYNQLMRIHEELGSRATYAGKKREIRHL
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase 1, 2-phospho-D-glycerate hydro-lyase 1, 2-phosphoglycerate dehydratase 1.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: HIS1_BUCAT
Sequence: MFENNRVRIAMQKTGRLSKDSIRLLTSCGVKINLKQQKLIAFAENMPIDVMLVRDDDIPGLVMDGVVDLGIVGENVLEEELLKRKSQKSECSYITLRRLDFGVCRLSLALPVNTIYTNITCLKNIRIATSYPHLLKKYLDEKNISFKSCMLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVQVVYHSHACLICKTGNINSIKKEFINKLMTRIKGVIKARESKYIMLHAPIKQLEAVISLLHGAERPTILKLAGDDNRVAMHMVSSETLFWETMEKLKLLGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.