PharMolix/UniProtQA huggingface dataset:
Protein: CSP_PLAFA
Sequence: MMRKLAILSVSSFLFVEALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPGDGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNNNEEPSDKHIEQYLKKIKNSISTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYENDIEKKICKMEKCSSVFNVVNSSIGLIMVLSFLFLN
What is the function of this protein?
In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
What are the official names of this protein?
Circumsporozoite protein, CS, PfCSP.
What is the protein family that this protein belongs to?
Belongs to the plasmodium circumsporozoite protein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasm. Note=Localizes to the cytoplasm and the cell membrane in oocysts at day 6 post infection and then gradually distributes over the entire cell surface of the sporoblast and the budding sporozoites.
Protein: CALC_BRAOB
Sequence: MGRGRVEMKRIENKINRQVTFSKRRAGLLKKAHEISILCDAEVSLIVFSHKGKLFEYSSESCMEKVLERYERYSYAEKQLKAPDSHVNAQTNWSMEYSRLKAKIELWERNQRHYLGEDLESISIKELQNLEQQLDTSLKHIPSRKVCK
What is the function of this protein?
Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1, FRUITFULL and LEAFY.  Is required subsequently for the transition of an inflorescence meristem into a floral meristem.  Seems to be partially redundant to the function of APETALA1 (By similarity).
What are the official names of this protein?
Truncated transcription factor CAULIFLOWER C, BobCAL-c, Agamous-like MADS-box protein CAL-C.
What are the subcellular locations of this protein?
Nucleus.
Protein: 1433_XENLA
Sequence: AKLSEQAERYDDMAASMKAVTELGAELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEGNDKRQQMAREYREKVETELQDICKDVLDLLDRFLVPNATPPESKVFYLKMKGDYYRYLSEVASGDSKQETVASSQQAYQEAFEISKSEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKSAFDEAIRELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGEEADNVEGDN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner.
What are the official names of this protein?
14-3-3-like protein.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: CFA57_HUMAN
Sequence: MSAVVAQTLHVFGLRSHVANNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPNRRYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYLLAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTLKQTSFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKSLDVIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAGPGRVLLFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLYSITMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRGCGECSFSNGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFDVTYTAIVISHSGRMMFVGTSVGTIRAMKYPLPLQKEFNEYQAHAGPITKMLLTFDDQFLLTAAEDGCLFTWKVFDKDGRGIKREREVGFAEEVLVTKTDMEEKAQVMLELKTRVEELKMENEYQLRLKDMNYSEKIKELTDKFIQEMESLKTKNQVLRTEKEKQDVYHHEHIEDLLDKQSRELQDMECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEKTTLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYEKKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIETLKGEQMKLQGVIKSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELGKFKFVLDYKIKELKKQIEPRENEIRVMKEQIQEMEAELENFHKQNTQLELNITELWQKLRATDQEMRRERQKERDLEALVKRFKTDLHNCVAYIQEPRLLKEKVRGLFEKYVQRADMVEIAGLNTDLQQEYTRQREHLERNLATLKKKVVKEGELHRTDYVRIMQENVSLIKEINELRRELKFTRSQVYDLEAALKLTKKVRPQEVSETEPSRDMLSTAPTARLNEQEETGRIIEMQRLEIQRLRDQIQEQEQVTGFHTLAGVRLPSLSNSEVDLEVKTN
What are the official names of this protein?
Cilia- and flagella-associated protein 57, WD repeat-containing protein 65.
Protein: RU2A_ASHGO
Sequence: MKLTPASILEAPVYYADHIHGKYDVDKVVILRDCGYVSENEIMPQTLKLLPERTNIVDFTNNELEELPPLGHNDTVHTLLLSRNRLGRLDASRLPRYLVNLNLAMNRFEKFEQLQGLRSAPKTLKNLNLRGNVICHKEQYRETVIALCPQLAVLDGERVRQAERQAAPQNEKTDTPTEGPQPVALQATSEKELQLMDHVVNKMDKDTLEDIKQQLAKATTLAEIERLEKLLSGGVIQ
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
U2 small nuclear ribonucleoprotein A', U2 snRNP A'.
What is the protein family that this protein belongs to?
Belongs to the U2 small nuclear ribonucleoprotein A family.
What are the subcellular locations of this protein?
Nucleus.
Protein: METK_LISIN
Sequence: MAKNRHLFTSESVSDGHPDKIADQISDAILDAIISKDPDARVACETTVTTGLVLVAGEITTSVYVDIPKIVRDTIKEIGYTRAKYGFDAETCAVLTAIDEQSPDIAQGVDEALESRSGSEIDAAIEAIGAGDQGLMFGFATDETEELMPLPIFLAHGLARKLTELRKTNKLDYLRPDAKTQVTVEYDEFNQPVRIDTIVVSTQHHPDITQEQIAKDLHTHLFPEVIDASFLDENTKYFINPTGRFVIGGPLGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSGAYAARYVAKNIVAAGLAKKVEVQVAYAIGVARPVSISIDTYGTSDYSEQELIDGVNELFDLRPAGIIHMLDLRRPIYRQTAAFGHFGRSDLDLPWERTDKAEALKKLIVK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPDA_ECO57
Sequence: MESLLTLPLAGEARVRILQITDTHLFAQKHEALLGVNTWESYQAVLEAIRPHQHEFDLIVATGDLAQDQSSAAYQHFAEGIASFRAPCVWLPGNHDFQPAMYSALQDAGISPAKRVFIGEQWQILLLDSQVFGVPHGELSEFQLEWLERKLADAPERHTLLLLHHHPLPAGCSWLDQHSLRNAGELDTVLAKFPHVKYLLCGHIHQELDLDWNGRRLLATPSTCVQFKPHCSNFTLDTIAPGWRTLELHADGTLTTEVHRLADTRFQPDTASEGY
What is the function of this protein?
Hydrolyzes cAMP to 5'-AMP.  Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
What are the official names of this protein?
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA, 3',5'-cyclic AMP phosphodiesterase, cAMP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase class-III family.
Protein: MUTL_METSB
Sequence: MPVRRLDPVLIDRIAAGEVIERPASALKELIENALDAGARRIDVAIEAGGRKLIRVVDDGCGMAPEDLDLAVERHATSKLPEGDLSSIETLGFRGEALPSIGSVAALEIFSRAMGSAVGARVKVDCGVKEGPAPAAQPQGTRVEIRDLFAGTPARLKFLRTDRAEARASAEIVERLAMAHPQVRFGFASSDVRGFDLAACADSPEGRLTRFSAVLGKDFRDNALFVEAEREGVRLQGFAGLPTWHRASAAAQHVFVNGRPVRDRLLLGAARAAYMDFLPSGRHAALVLFLTCDPREVDVNVHPAKAEVRFRDPGLTRGLIVGALKQTLADAQHRASPVNGASALDVLARRGPGFSGAGGPANWDWRRSPANPGFDAAALAGFAEAPAAAFAAVESLAADTRANAAAPSLEDLEAPLGAARAQIHETYIVSQTRDGIVIVDQHAAHERLVYERLKAARAGSKAPRQALLIPAIVELARAEVEAILDAAVLLAEFGLIIEPFGPGAVAVTETPALLQDPDPTRLARDLAAALVEDDGAAALERRFNLVLATMACHNSVRAGRRMRPEEMNALLRDMERTPGSGQCNHGRPTYVELKLADVEKLFGRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: KDGT_ECO8A
Sequence: MQIKRSIEKIPGGMMLVPLFLGALCHTFSPGAGKYFGSFTNGMITGTVPILAVWFFCMGASIKLSATGTVLRKSGTLVVTKIAVAWVVAAIASRIIPEHGVEVGFFAGLSTLALVAAMDMTNGGLYASIMQQYGTKEEAGAFVLMSLESGPLMTMIILGTAGIASFEPHVFVGAVLPFLVGFALGNLDPELREFFSKAVQTLIPFFAFALGNTIDLTVIAQTGLLGILLGVAVIIVTGIPLIIADKLIGGGDGTAGIAASSSAGAAVATPVLIAEMVPAFKPMAPAATSLVATAVIVTSILVPILTSIWSRKVKARAAKIEILGTVK
What is the function of this protein?
Catalyzes the proton-dependent uptake of 2-keto-3-deoxygluconate (KDG) into the cell.
What are the official names of this protein?
2-keto-3-deoxygluconate permease, KDG permease.
What is the protein family that this protein belongs to?
Belongs to the KdgT transporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAB45_XENLA
Sequence: MVSKQAFLFSLGSLYLSLLFIFLLMDVYARPANNSALKVETKEKATDNKDENEILPPDHLNGVKMEMDGHLNKEFHQEVFLGKELEEFDEDSEPRRNRRKLAAIFAKVDRNEDKQISASEMQRWIMEKTEEHFQEAVNENKLHFRAVDPDGDGHVSWDEYKIKFLASKGFNEKEVAEKLKNNEDLKIDEETQEVLDNLKDRWFQADNPPPDQLLNEEEFLSFLHPEHSRGMLKFMVKEIIRDLDQDGDKKLTLSEFISLPVGTVENQQAQDIDDDWVRDRKKEYEEVIDANHDGIVTMEELEEYMDPMNEYNALNEAKQMIAVADENQDHLLSLEEILKYSEYFTGSKLMDYARNVHEEF
What is the function of this protein?
May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
What are the official names of this protein?
45 kDa calcium-binding protein, Cab45, Stromal cell-derived factor 4, SDF-4.
What is the protein family that this protein belongs to?
Belongs to the CREC family.
What are the subcellular locations of this protein?
Golgi apparatus lumen.
Protein: RS12_PROM5
Sequence: MPTISQLIGSERKRLTRKTKSPALKSCPERRGVCTRVYTSTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVLLRGGRVKDLPGVRYHIIRGTLDTAGVKDRRQSRSKYGAKAPKNN
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: ERA_BORHD
Sequence: MKSGFVSIIGRPSTGKSTLLNSICGHQISIISSTPQTTRNKIKGIFTDKRGQIIFIDTPGFHLSKKKFNIALMNNVHSAITETELILYVIDIQDEPGIEENEILTIISKSKINFLVVINKIDIQKTKEREIMIFLEKKGIKKDNIIKISAEQKINIEEIKDKIYANLQEGPLYYPEEYYTDQEMNLRTSEIIRGVTIKKLKEELPYSLYTQIEILEDRKNKLFIKANIIVAGESQKGIIVGKGGQGIKAIGEEARKIISKIFEKKCDLFLQVKLRKNWNKNSKLIKNLIN
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: UPP_STRGC
Sequence: MGKLEVIAHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEVLRDLPLEDVEIETPITKTIQKQIAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGMYRDEETLKPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGASHITFVCLVSAPEGVKALQEAHPDVDIFTAALDDHLNDHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: SECM_ECO45
Sequence: MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS
What is the function of this protein?
Regulates secA expression by translational coupling of the secM secA operon.  Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
What are the official names of this protein?
Secretion monitor.
What is the protein family that this protein belongs to?
Belongs to the SecM family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Periplasm. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.
Protein: SRS7_ARATH
Sequence: MAGLFYLGGRDHNKQDHHQEKDHNEDKSNNYLYLYKDEIYNNNKGFEIFPPQYFQQQQQQNHAAAPTNLYSFGMVPSGGNINNNRSTNRSLYFNVVSDHEPVRSSTGGFTVTRQGNMNCQDCGNQAKKDCPHMRCRTCCKSRGFDCQTHVKSTWVSAAKRRERQAQLAVLPAKRIRDANSRGGGDDDDDDKEDEKNDSCGGGSALACTRVVNASSSGLETSHLPPEISSPAVFRCMRVSSIDDEDEEYAYQTAVSIGGHVFKGILYDQGPSSDHHRYSSSLNGETSHQHHLNLMDSTPSAATTNAVTAVNTNNGSIDPSSLYTAVATPFNAFVAGGTPFFASSRC
What is the function of this protein?
Transcription activator that binds DNA on 5'-ACTCTAC-3' and promotes auxin homeostasis-regulating gene expression (e. g.  YUC genes), as well as genes affecting stamen development, cell expansion and timing of flowering.  Synergistically with other SHI-related proteins, regulates gynoecium, stamen and leaf development in a dose-dependent manner, controlling apical-basal patterning.  Promotes style and stigma formation, and influences vascular development during gynoecium development.  May also have a role in the formation and/or maintenance of the shoot apical meristem (SAM).  Regulates anther dehiscence and floral development.
What are the official names of this protein?
Protein SHI RELATED SEQUENCE 7.
What is the protein family that this protein belongs to?
Belongs to the SHI protein family.
Protein: RL11_CHLL2
Sequence: MAKKIIGFIKLQIPAGAANPAPPVGPALGQKGVNIMEFCKQFNAKTQSEAGMITPVVITVYSDKSFTFVTKTPPAAVLLLKEAKLQKGSGEPNRNKVGTVSREQVRRIAELKMPDLNAFDLDGAEQMVMGTARSMGIIVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: UNG_STRP3
Sequence: MAHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPQRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGAYARKKKAFITNPKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_OPHHA
Sequence: MAKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVRKSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEEGLKTKKQQRKERLYPPRKYAVKA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYN_LEPBL
Sequence: MSEIPIVSNHDLEKYVDRKVVIQGWVHGIRGSNARQFISLRNGGRILQVLAEKEILGEEVFQTVKHLRQETSVSVAGTLVKNEKSSVGFELIMDRIRIVGESENYPITPKEHGIDFLISQRHLWLRSSKQLAILRVRDNLSFAIRKYFHERDFLLIDTPILTGSVGESAGTLFSTEYFDLGNAYLAQTGQLYLEAAIFAHNKVFCYGPTFRAEKSKTRRHLTEFWMVEAEVAFAGHADNLKLQEDFVKTVIKETVQNSLQDLKVLERDPTPLLAYLEKDFPVIDYTKALEILKLKGEDIVWGDDINSEREQMLTMEFGGPIFIQKYPREAKAFYMKVNPDNPKTVLNADLIAPDGVGEIIGGSEREENYENIILRLEEEKLPVESYDWYLDLRKYGSVPHSGFGLGSERMIAWICGLQHVRECIPFPRMMERLYP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU3C_PROM3
Sequence: MAVNARLISKSYLSMFALPGYDAFLGFLLVSAAVPILALVTNKLLAPRSRTGERELTYESGMEPIGGAWIQFNIRYYMFALVFVIFDVETVFLYPWAVAFHRLGLLAFIEALIFIAILLVALAYAWRKGALEWS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3, NDH-1 subunit 3, NDH-C.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: MAZE_MYCS2
Sequence: MTPARDRVRRHRERLRRQGLRPVQIWVPDVNAPEFRREAHRQSELVAAGEHEAEDQAFVDAISVDWDDA
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Neutralizes the effect of cognate toxin MazF.  In M. smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions.
What are the official names of this protein?
Antitoxin MazE.
Protein: FTHS_AERS4
Sequence: MLSDIEISRQSPRLSIQALASRLGIPAHLLSPHGHYKGKLSLELLKQAASKPGKKAGKLVLVSAITPTPLGEGKTVTTLGLSMGLNHIGQPSMATIRQPSLGPVFGVKGGAAGGGHAQVVPMEEMNLHLTGDFHALTAAHNLAAAALDARLFHETKLGTEFTARTGLARLDIDPANILWPRTLDMNERALRHLTIGQGAAADGVERQDRFVITAASELMAILALASDLKDLRARIGRIQLALDSQGQPITAEQLEVAGAMTVLLKDALQPTLMQTTEQTPVLVHAGPFANIAHGNSSVIADRMALQLTDYVVTEAGFGSDMGLEKFFNIKHRQSGITPACVVLVATVRGLKANSGLLDIRPGQPLPASLLGEDLPTLEKGCANLAWHIHNARRYGLPVVVAVNSFPTDSKAELDLLMREARQAGACGAAISTAFVEGGAGASELARAVVAACEMPSQIQLLYPDEMSLCAKLATLVECGYGGRGVILSDKAHRQLAALSAAGWDHLPICVAKTPLSISHDPARKGVPTDFEVPIDEVKLCAGAGFVYALAGPIMTMPGLGSLPAYRHIDIGEDGEIVGLS
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: PUR5_VIBVU
Sequence: MSGNNSSLSYKDAGVDIDAGNALVERIKGSVKRTRRPEVMGGIGGFGALCELPTKYKQPVLVSGTDGVGTKLRLALDMNKHDTIGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAADVISGIAEGCIQAGCALIGGETAEMPGMYEGEDYDVAGFCVGVVEKEDIIDGTKVAVGDALIAVGSSGPHSNGYSLVRKILEVSGADKNEELAGRTIGEHLLEPTKIYIKSALKMIEQHDIHAISHITGGGFWENIPRVLPEGTKAVIDGKSWEWPVIFQWLQEKGNVATREMYRTFNCGVGLIVALPQDQAEAAVALLQQEGEKAWVIGAIAQAEAGEEQVEIN
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_I76AC
Sequence: QDLPGTDNSTATLCLGHHAVPNGTIVKTITDDQIEVTNATELVQTSSTGKICNNPHRILDGRDCTLIDALLGDPHCDVFQDETWDLFVERSNAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPANGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTNLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGQSGRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDALIDTCVSECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLAIGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNGKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNADVLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNTCIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: WNT7A_CALJA
Sequence: MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).  Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development.  Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).  Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes.  Required for normal neural stem cell proliferation in the hippocampus dentate gyrus.  Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation.  Promotes formation of synapses via its interaction with FZD5 (By similarity).
What are the official names of this protein?
Protein Wnt-7a.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: SUCC_NATPD
Sequence: MKLHEYQAKGVFADAGIPVPESTLASTVDEAVEAADDIGYPVAIKAQVQVGGRGKAGGIKLVENADEAREAADEILGMDLKGLHVDRVLVEAAVDFTDELYVGVTMDRAAGKPVAMVSTRGGVNIEEVAEEDPDAIVREHIDPAFGMHPFQARKAAFEAGVDRAVANDVASILTQLYELWADKDATEIEVNPLMVTDDDEVIAADAVMNIDEDALFRHPDLEEMEEEAAGDELEAKANEYGFDYVRLSGNTGIIGNGAGLVMTTLDLVDHYGGEPANFLDIGGGAKAERVANALDMVFSDDNVDSVVFNIFGGITRGDEVAKGINEALEQFDEIPKPVVVRLAGTNAEEGMEILNTDLVTVEKTLEDAVQRAVKYAEEEQ
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: POLR_PHMV
Sequence: VIVGTPPISPNWPAIKDLLHLKFKTEITSSPLFCGYYLSPAGCIRNPLAHFAKLMTCVDDMSLPEKVLSYLSEVSIGHNLGDQIIQHLPPHLIQYQSACFDFFCRNCTPSQKLLLSNDPIPESKLLALVHKIKWASKAFFSELPQKAREFLVSKSSLPSFPNNPKVSELESELLHFSQ
What are the official names of this protein?
RNA replicase polyprotein.
What is the protein family that this protein belongs to?
Belongs to the tymovirus NS35 RNA replicase polyprotein family.