PharMolix/UniProtQA huggingface dataset:
Protein: AQP2_CANLF
Sequence: SVAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHVSGAHINPAVTVACLVGCHVSFLRAAFYVAAQLLGAVAGAALLHEITPPHVRG
What is the function of this protein?
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
What are the official names of this protein?
Aquaporin-2, AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
Protein: TRPD_SYNY3
Sequence: MNTTASSPWPPFLQQLLDRQSLTRQQAVQLMEGWLDDDIPPALSGAILAAIQAKGLDPEELTGMAQVLQEQSQGNQGREMVAPLVDTCGTGGDGSSTFNISTAVAFVVAAAGVKVAKHGNRSASSKVGSADVLEALGLNLQAGADQVAAAVSAVGITFLFAPGWHPALKSVAPIRKTLKVRTVFNLLGPLVNPLRPTGQVIGVYSPDFLSVMAIALKNLGTARAMVLHGREQLDEAGLGAPTDIASFNQGEVTPQVLDPQNFGLAPAPLTALKGGDLAENVTILSQVLQGKGTQAQIDAVALNASLALQVGDAVPWGDHGQGIHLAKDILSQGAGWDKLQQLVAFLGS
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RS18_RHIL3
Sequence: MSETSSAPVRRPFHRRRKTCPFSGANAPRIDYKDVRLLQRYISERGKIVPSRITAVSQKKQRELAQAIKRARFLGLLPYVVA
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: MURI_ROSS1
Sequence: MSDQSARPIGLFDSGIGGMTVLREVRRLLPGENLLYLADQARCPYGSRSPDELRAIAAACAAWLIARGAKLVVVACNTASAAALADLRRRFPAIPFVGMVPPVKPAASRTRSGVVGVLATPATLAGDLLHDVISRWAEGVHVIEQACPGLVEQIEEGALDSPETMALLRGYVTPLLDAGADTIVLGCTHYPLLVPQLRAIAGDDTLILDAAPAVAQRVAQIVQERGLMRNVNTLSGAITCATTGDPERFANLIHRLDLPCDRVEQAVITIDA
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: YBAB_ECO81
Sequence: MFGKGGLGNLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRVEIDPSLLEDDKEMLEDLVAAAFNDAARRIEETQKEKMASVSSGMQLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein YbaB.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL21_NITEU
Sequence: MYAVIKTGGKQYRVEVGNKLKVETLPAEVGSDIQLDQVLMIADGEAISAGAPLLDQAKVSATVVSHGRHDKIRIFKMRRRKHYRKQQGHRQNYTEIQITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RL3_LACCB
Sequence: MARKGILGKKVGMTQVFTDNGELVPVTVVDVTPNVVMQVKTVESDGYEAVQLGYGDMREVLTNKPSVGHAKKADTTPKRFVREIRDVALSDYEIGSEVKADEFAAGDIVDVTGTSKGHGYQGNIKKDGQSRGPMAHGSRYHRRPGSLGAIINKVFKGKKLPGRMGNHTRTMQNLQVVAADTEHNVLLIKGNVPGANKSFVTIRSAVKAAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: NUSG_SYNY3
Sequence: MSFTDDQSPVAEQNKKTPSEGHWFAVQVASGCEKRVKLNLEQRIHTLDVADRILQVEIPKTPIVKIRKDGARVQGEEKIFPGYVLIRMIMDDDAWQVVKNTPHVINFVGSEQKRHYGRGRGHVLPMPLSHGEVERIFRHVDEQEPVVKIDMEIGDHIMVLSGPFKDFEGDVIEVSPERSKLKALLSIFGRETPVELEFTQVEKQN
What is the function of this protein?
Participates in transcription elongation, termination and antitermination.
What are the official names of this protein?
Transcription termination/antitermination protein NusG.
What is the protein family that this protein belongs to?
Belongs to the NusG family.
Protein: GHRB_ECOLI
Sequence: MKPSVILYKALPDDLLQRLQEHFTVHQVANLSPQTVEQNAAIFAEAEGLLGSNENVNAALLEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARRVVEVAERVKAGEWTASIGPDWYGTDVHHKTLGIVGMGRIGMALAQRAHFGFNMPILYNARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMKSSAIFINAGRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIGSATHETRYGMAACAVDNLIDALQGKVEKNCVNPHVAD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.  Can also reduce 2,5-diketo-D-gluconate (25DKG) to 5-keto-D-gluconate (5KDG), 2-keto-D-gluconate (2KDG) to D-gluconate, and 2-keto-L-gulonate (2KLG) to L-idonate (IA), but it is not its physiological function.  Inactive towards 2-oxoglutarate, oxaloacetate, pyruvate, 5-keto-D-gluconate, D-fructose and L-sorbose.  Activity with NAD is very low.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B, 2-ketoaldonate reductase, 2-ketogluconate reductase, 2KR.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_HAEDU
Sequence: MTAANQNYGTGRRKSSSARVFIKPGSGNITINQRSLEVYFGRETSRMVVRQPLELVELLDKLDLYITVKGGGISGQAGAIRHGITRALMEYDETLRPALRAAGFVTRDARRVERKKVGLHKARRRPQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: FLGE_BRUSU
Sequence: MSLYGMMRTGVSGMNAQANRLSTVADNIANASTVGYKRAETQFSSLVLPSTAGQYNSGSVLTDVRYGISDQGGIRSTSSTTDLAIDGNGYFVVQGPGGSTYLTRAGSFVPDKNGDLVNSAGYYLLGAGADEAAGGLTVAGLNVVNVNAAALPAEGSTAGDFTVNLPSTDQAPAAGGYNHKTSLISYNDKGEKITLDVYFTKTGADEWNVSVKNAADGVEIGTTVLNFDPTTGDLVSGGNVAVNLGAYGGQTLNLNLGGSTQRAGDYTISQAVINGQAPSSIKGVDVGNDGAVVAVYENGTQKVLYRIPLANVASPNRMTVVSGNIFLPSAESGDVRLGFPQGDGMGKIMSGTLEESNADIAQELTDMIEAQRSYTANSKVFQTGSELMDVLVNLKR
What are the official names of this protein?
Flagellar hook protein FlgE.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: RS5_STRTD
Sequence: MAFKDNAVELEERVVAINRVTKVVKGGRNMRFAALVVVGDRNGRVGFGTGKSQEVPEAIRKAVEAAKKNLIEVPMVGTTIPHEVRSEFGGAKVLLKPAVEGAGVAAGGAVRAVVELAGVADVTSKSLGSNTPINIVRATVEGLKQLKRAEEVAALRGISVSDLA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: SED1_ASPFU
Sequence: MRLSHVLLGTAAAAGVLASPTPNDYVVHERRAVLPRSWTEEKRLDKASILPMRIGLTQSNLDRGHDLLMEISDPRSSRYGQHLSVEEVHSLFAPSQETVDRVRAWLESEGIAGDRISQSSNEQFLQFDASAAEVERLLGTEYYLYTHQGSGKSHIACREYHVPHSLQRHIDYITPGIKLLEVEGVKKARSIEKRSFRSPLPPILERLTLPLSELLGNTLLCDVAITPLCISALYNITRGSKATKGNELGIFEDLGDVYSQEDLNLFFSTFAQQIPQGTHPILKAVDGAQAPTSVTNAGPESDLDFQISYPIIWPQNSILFQTDDPNYTANYNFSGFLNTFLDAIDGSYCSEISPLDPPYPNPADGGYKGQLQCGVYQPPKVLSISYGGAEADLPIAYQRRQCAEWMKLGLQGVSVVVASGDSGVEGRNGDPTPTECLGTEGKVFAPDFPATCPYLTTVGGTYLPLGADPRKDEEVAVTSFPSGGGFSNIYERADYQQQAVEDYFSRADPGYPFYESVDNSSFAENGGIYNRIGRAYPDVAAIADNVVIFNKGMPTLIGGTSAAAPVFAAILTRINEERLAVGKSTVGFVNPVLYAHPEVFNDITQGSNPGCGMQGFSAATGWDPVTGLGTPNYPALLDLFMSLP
What is the function of this protein?
Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
What are the official names of this protein?
Tripeptidyl-peptidase sed1, Sedolisin-A.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: ARLY_ACAM1
Sequence: MTSSPVPPTNSSDSSDSKVWSQRFESALNPVIAAFNASIHFDIALIEYDLTGSQAHVQMLAHSGIISQAEADAIDQGLEAIRQEYRQGQFQPGIEAEDIHFAVENRLIELIGDTGKKLHTGRSRNDQVGTDLRLYLHDQILQVQTLIRNWQQALVILASDHVQTLIPGYTHLQRAQPISLAHHLLAYFEMAERDWQRLREIDRRVNVSPLGLGALAGTPFPIDRQYTADKLGFADLYRNSLDGVSDRDFAIEFLCAASLIMVHLSRFSEEVILWASEEFGFIKLKDSCATGSSIMPQKKNPDVPELVRGKSGRVFGHLQSLLVVMKGLPLAYNKDLQEDKEAIFDGVTTIKACLEAMTILVAEGLEFQTPRLESAVGEDFSNATDVADYLSKQGVPFREAYNIVGAVVKTCLSQNKLLKDLTLEEWQQFHPQFADDIYSAISPRQVVAVRNSFGGTGFTQVQNALEQAKTLLSQSK
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_SALPB
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVLEIVSGASRGIRLLQEEEDGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPSADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFTPIVVDLREQSFTIEGLAVGVIRNGEWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: MINE_XANC8
Sequence: MGLLDFLKSKKNTAETAKNRLQIIIAQERNHRGGPDYLPLMQRELLEVIKKYVNIDADAVRVDLVKDGEHDVLDITVALPEDGDK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: HIS2_LACLA
Sequence: MRPDFHKQELIPVIVQDYQTNQVLMLAYTNEVAFEKMLETGETWFWSRSRQKLWHKGEESGHFQKIKGMRLDCDQDTLLVFVEQIGNACHTGTYSCFYDELIPFDDSDIFSELEKQIIDRKLHPVEKSYTNYLLGEGIDKVLKKVGEEASEVIIASKNSDKGELLGEIDDLLYHLFVLMNQQGISLEEVRQKAKERHQLEGNKKEFHTRTAD
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisIE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MANEL_DANRE
Sequence: MNRLRRKACVALLLFTLFIFGTMMGLRTLKPTDGFSDLAPGMELMPLVGERMEQRPNHLIESAGQNGGLHSDTKIVFSNSGPDHSIFYDIHIFYYLWYGSPQMDSSYIHWDHVLVPHWDPKIAASHPKGRHNPPDDIASSYYPELGPYSSRDPEVIESHMAQIEAAAAGVVVLSWYPPGVADEHGKPSEDLVPAVMDAAHKHSIKVAFHLQPYKGRTDISVHDNIKYIIDTYGTHGAFYRFKSSTGKILPLFYVYDSYLTPPETWAELLTIRGSHSLRGTPYDGIFIALIVEERHKQDILAGGFDGMYTYFASNGFSFGSSHQNWKAIKAFCDKNNLLFVPSAGPGYMDTAVRPWNNHNTRNRVNGRYYETSLQAAMSVRPDIITITSFNEWHEGTQIERAVPKKTVARLYLDYKPHQPDHYLELTKKWAEHFSKEKEQWLM
What are the official names of this protein?
Glycoprotein endo-alpha-1,2-mannosidase-like protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 99 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: TRPD_BACCQ
Sequence: MNNYLRKLVEGQHLTEEEMYKAGLLLLNENILESEIAAFLVLLKAKGETAEEIYGLVRALREKALPFSNHIQGAMDNCGTGGDGAQTFNISTTSAFVLAGADVKVAKHGNRAVSSKTGSADLLEELGVNISSTPNEIDYLLEHVGIAFLFAPAMHPALKRIMKIRKELNVPTIFNLIGPLTNPVNLETQFVGIYKRDMLLPVAQVLQKLGRKQALVVNGSGFLDEASLQGENHVVILKDNEIVETSIEPEKYGFSIVKNEEIRGGNSKENAKITLGVLSGEKSVYRDTVLFNAGLALFANGKAKTIEEGITLAAHSIDSGKALAKLNLLIAASNEKLERVN
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: UUP_BUCAP
Sequence: MPLISIQNAFLAFSDLEILKNAVLYINKKERISLIGKNGAGKSTLLKVINKNQELDHGSIIYQKNIKISYLKQDNPKNLDISIYDFIKNQLKKENNKEININTIVEIKKIIKTFQIDKHSLLSELSGGSLRKVVLGSALLSQPDVLLLDEPTNHLDINTIAWLEKFLKKFSGTTLFISHDRSFIQNLCTRIIDLDRGKLTSFPGDYKEFIKLKKENNRIEKTKKKLFDQHLEKEEIWIRKGIKARTTRNEGRVRNLKVLRKEYKNYKKIENFNNVIINEIKNYSGKIIFKLKNISFFIEKKTIIQSFSSIIQYGDKIGLIGNNGSGKSTMIKILMGEKKIQKGSIHFGTKLNIAYFDQDRSTLDSNKSILENVNNGREKIVLNGKEQHLIGYLKKFLFKPNQMKCLVKNLSGGECNRLLLAKLFLKPSNVLILDEPTNDLDLDTLELLENIIIKYSGTVLIVSHDRNFIENTVNKYWIFKGDGLINTHFSSHNNIIKEKNKKIQKKYVLNPIKSNISFLKTKQNQVKKELKKVLNEIEKIENSIKTLKIQMNEPDFFKQHIKNQLPIVKQFNIEEKKLEKILIYWENLEKKL
What is the function of this protein?
Probably plays a role in ribosome assembly or function.  May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps.  Binds DNA and has ATPase activity.
What are the official names of this protein?
ATP-binding protein Uup.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associates with ribosomes.
Protein: RECO_ALTMD
Sequence: MNNEWLNAYVLHRRPYRETSYIVDFFSLEEGRISAVAKGVKNSKSDKKSLLQPFQHLRLQLSGKSDLKNLRHVESVAPSISLTGTALFCAMYVNELTNRIMPQGLASDGVYSAYEAALLALRDEADIEVTLRQLEFALLDEMGLLPDFTSDVEYEMPIEENGRYHFQLDAGFIQIPDDVVGARGIPGTALLSLSQGEFTPLSKKVAKVLCRDLLKPLIGDKPLKSRELFMTKPR
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: ASNA_PLAYO
Sequence: MSEGGSDVSSLSCSLSLDSDSCEDEFYETNLNKLIENTSLNWIFVGGKGGVGKTTTSCSIAIQLAKKRESVLLLSTDPAHNTSDAFNQKFTNKPTLINSFDNLYCMEIDTTFSEDTAFKINQSNFLNSIIPELLQSFPGIDEALCFAELMQSIKNMKYSVIVFDTAPTGHTLRLLAFPDLLKKALGYLINLKEKLKGTLNMLQSLTNNEMEFEGMYDKINHLNTMSISIQENFQNPLKTTFVCVCIPEFLSVYETERLIQELTKKNISCYNIVVNQVVFPLICPDANIEKCENLLKQIKDTNIQDSFNTLILKAKELEDVYISRRKLQSKYLTQIKNLYGNYFHIVCMPQLKTEIRGLDKISNFSEMLLQSKDIPIYSPQ
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase ASNA1 homolog, Arsenical pump-driving ATPase homolog, Arsenite-stimulated ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: SPD10_HUMAN
Sequence: MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVSGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS
What are the official names of this protein?
Speedy protein E10.
What is the protein family that this protein belongs to?
Belongs to the Speedy/Ringo family.
Protein: MIDN_RAT
Sequence: MEPQPGGARSCRRGAPGGACELSTTAESAAPMSLAIHSTTGTRYDLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQPPATPGPGRAAGGGFRKYRLILFKRPWHRQGPQSPERGGERPQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAAAAAAARGDSSIATPVSSPCRPVSSAARVPPVSSSPSSPVSPSPVTAGTFQSHAASTTCPEQTDCSPPASSNTTSTPGSSPTPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQGMPASLTQLRCHAQCSPASPAPDLTPKTTSCEKLATPSLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWTPSRKAGRSDSSSSGGGGSPSEATGLGLDFEDSVWKPEVNPDIQSEFVVA
What is the function of this protein?
Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4 (By similarity).  Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (PubMed:24187134).
What are the official names of this protein?
Midnolin, Midbrain nucleolar protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Nucleus, nucleolus. Note=Detected in the nucleus and nucleolus with no expression in the cytoplasm (By similarity). However, a later study finds expression in the nucleus and cytoplasm with no expression in the nucleolus (PubMed:24187134).
Protein: YCIB_CUPTR
Sequence: MKFLFDLFPVILFFAAFKLADIYTATAVAIGATVLQIGWVWFRHRKVEPMQWVSLLIIAVFGGATLVLHNETFIKWKPTVLYWLFAAALLGSVLVWRKNLIRAMMEKQVSLPDPVWARLNLAWAGFFAAMGVLNLYVAYQFSTEAWVNFKLFGSMGLMLVFIVAQSVWLSRHMPENTQD
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YIDD_HYDCU
Sequence: MNPFKWLIILPVRFYQLFISPILGPRCRFYPTCSHYTIEAVQQHGVFCGLWLAIKRIAKCHPGNPGGVDPVPSCGCHSDKETTPKEKSDNA
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: UBIB_ECOUT
Sequence: MTPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLALQELGPVWIKFGQMLSTRRDLFPPHIADQLALLQDKVAPFDGKLAKQQIEAAMGGLPVEAWFDDFEIKPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIKADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGMMVMERIYGIPVSDVATLEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPENPKYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRAFKEKAPFWVEKMPELPELVYDSLRQGKYLQHSVDKIARELQSNHVRQGQSRYFLGIGATLVLSGTFLLVSRPEWGLMPGWLMAGGLIAWFVGWRKTR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NU4M_ASCSU
Sequence: MLDILLFSLYFFFEPVLFFFFMVVFGFVALNNYSWLGCFYFFDSFSFILLIVMSLFILGVVLLSESNFMLLLLSEVLVVVCVFFFVPSNVILMYMYFELSMFPILVMILGYGSQIEKINSSYYLIFYAALCSFPFLFVYFKSFFFISLVYFDFNLSWEMVFVLSLSFMMKFPVYFLHLWLPKAHVEAPTTASMLLAGLLLKLGTAGFLRILGCLSFVHNNVWIVLAFLGMILASFCCMFQSDAKALAAYSSITHMSFVLMALVFIIMSGKTGGVILMLAHGYTSTLMFYLVGEFYHVSGSRMVYYMSSFFGSGMIMALLFAVVFLSNMGTPPSLSFLSEFIVISSSLNMMKFSFWVLFVYFFSAFYYSIYLLTSSVMGKGYVNFSIWNVGFSVPLVFMMYNIFWMSVFF
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: TSAC_HAHCH
Sequence: MSAWFIQKAVSVLSRGGVLAYPTEAVWGLGCDPSCEDAVNRILQLKRRPWRKGLILVSGQIEHFSQLLDRLPQQQKDQILATWPGPVTWVVPDPGVYAPLVRGAHDAIAIRVTAHPLVVELTKAFGGPIVSTSANPATREPARTLFDCRRYFKSGVDHYLPGKLSGLSKPSQIRDAATGAILRQ
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNDA_HUMAN
Sequence: MVNEYKKILLLKGFELMDDYHFTSIKSLLAYDLGLTTKMQEEYNRIKITDLMEKKFQGVACLDKLIELAKDMPSLKNLVNNLRKEKSKVAKKIKTQEKAPVKKINQEEVGLAAPAPTARNKLTSEARGRIPVAQKRKTPNKEKTEAKRNKVSQEQSKPPGPSGASTSAAVDHPPLPQTSSSTPSNTSFTPNQETQAQRQVDARRNVPQNDPVTVVVLKATAPFKYESPENGKSTMFHATVASKTQYFHVKVFDINLKEKFVRKKVITISDYSECKGVMEIKEASSVSDFNQNFEVPNRIIEIANKTPKISQLYKQASGTMVYGLFMLQKKSVHKKNTIYEIQDNTGSMDVVGSGKWHNIKCEKGDKLRLFCLQLRTVDRKLKLVCGSHSFIKVIKAKKNKEGPMNVN
What is the function of this protein?
May act as a transcriptional activator/repressor in the myeloid lineage.  Plays a role in the granulocyte/monocyte cell-specific response to interferon.  Stimulates the DNA binding of the transcriptional repressor protein YY1.
What are the official names of this protein?
Myeloid cell nuclear differentiation antigen.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.
Protein: TSYL1_MOUSE
Sequence: MSSPERDEGTPVPDSRGHCDADTVSGTPDRRPLLGEEKAVTGEGRAGIVGSPAPRDVEGLVPQIRVAAARQGESPPSVRGPAAAVFVTPKYVEKAQETRGAESQARDVKTEPGTVAAAAEKSEVATPGSEEVMEVEQKPAGEEMEMLEASGGVREAPEEAGPWHLGIDLRRNPLEAIQLELDTVNAQADRAFQHLEQKFGRMRRHYLERRNYIIQNIPGFWMTAFRNHPQLSAMIRGRDAEMLRYVTSLEVKELRHPKTGCKFKFFFRRNPYFRNKLIVKEYEVRSSGRVVSLSTPIIWRRGHEPQSFIRRNQDLICSFFTWFSDHSLPESDRIAEIIKEDLWPNPLQYYLCREGIRRPRRRPIREPVEIPRPFGFQSG
What are the official names of this protein?
Testis-specific Y-encoded-like protein 1, TSPY-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.