PharMolix/UniProtQA huggingface dataset:
Protein: PE2R3_RABIT
Sequence: MKETRGDGGSAPFCTRLNHSYPGMWAPEARGNLTRPPGPGEDCGSVSVAFPITMLITGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSKQRWEQLDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTIQWPGTWCFISTGRGDNGTSSSHNWGNLFFASTFAFLGLLALAITFTCNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTDTGKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQVIHENNEQKDEIQRENRNVSHSGQHEEARDSEKSKTIPGLFSILLQADPGARPYQQ
What is the function of this protein?
Receptor for prostaglandin E2 (PGE2) (PubMed:8119961).  Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS).  Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation.  Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration.  Not required for normal kidney function, normal urine volume and osmolality (By similarity).
What are the official names of this protein?
Prostaglandin E2 receptor EP3 subtype, PGE receptor EP3 subtype, PGE2 receptor EP3 subtype, Prostanoid EP3 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DEM2_PHYSA
Sequence: MSFLKKSLLLILFLGLVSLSVCKEEKRVSEEENENEENHEEGSEMKRYAFGYPSGEAKKIKRESEEEKEIEENHEEGSEMKRYAFGYPSGEAKKIKRESEEENENEENHEEGSEMKRYAFGYPSGEAKKIKRESEEEKEIEENHEEGSEMKRYAFGYPSGEAKKIKRESEEENENEENHEEGSEMKRYAFGYPSGEAK
What is the function of this protein?
Dermorphin has a very potent opiate-like activity.  It has high affinity and selectivity for mu-type opioid receptors.
What are the official names of this protein?
Dermorphin-2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermorphin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NDK_LEPIC
Sequence: MSRTFIMIKPDGVKNKHVGNILSRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAVLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSDDNAALEISFFFKGNELF
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPOB_XENNA
Sequence: MKRILFVILSTMLLASCVLPEATQQPAPVTPVEPKEKQETTPIEPSEKVLQPPKIQSINWNGIVQPLIEEMAKAHGVETGKVLLVDSVKNNTNGSLRTLKATEAIIDAISNKHIFQIVSRSQIHLARQALGLSTEDSLGLRSKSIGLARYLSADYVLYSVVSSNKGQRDLEMQLMLVKTGEILWSGHRDIN
What is the function of this protein?
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).
What are the official names of this protein?
Penicillin-binding protein activator LpoB, PBP activator LpoB.
What is the protein family that this protein belongs to?
Belongs to the LpoB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: SP5G_GEOSW
Sequence: MEVTDVRLRRVNTEGRMKAIASITLDNEFVVHDIRVIDGNNGLFVAMPSKRTPDGEFRDIAHPINSATRGKIQEAILAEYHRLGKLEEELEEAGAS
What is the function of this protein?
Could be involved in septation.
What are the official names of this protein?
Putative septation protein SpoVG.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: PRT3A_ONCMY
Sequence: PRRRRRSSSRPIRRRRRPRVSRRRRRGGRRRR
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine-3A.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CMBL_RAT
Sequence: MANEANPCPCDIGHRLDYGGMGQEVQVEHIKAYVTRSPVDAGKAVIVVQDIFGWQLSNTRYMADMIAGNGYTTIVPDFFVGQEPWDPAGDWSTFPEWLKSRNARKINREVDAVLRYLKQQCHAQKIGIVGFCWGGIVVHHVMTTYPEVRAGVSVYGIIRDSEDVYNLKNPTLFIFAENDAVIPLEQVSILIQKLKEHCIVNYQVKTFSGQTHGFVHRKREDCSPADKPYIEEARRNLIEWLNKYI
What is the function of this protein?
Cysteine hydrolase.
What are the official names of this protein?
Carboxymethylenebutenolidase homolog, Liver regeneration-related protein LRRG072.
What is the protein family that this protein belongs to?
Belongs to the dienelactone hydrolase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: IF2_STRGC
Sequence: MSKKRLYEIAKELGKESKEIVQRAKELGLDVKSHSSSVEAATADKIVASFASAKKAVAGTSEAKAKPSTEPIKTEATPSKPAKDKTEQATNKPSPSPASSPKPVEEASAKAPASKQEQAQGTAAPKVTRPQSRNFKAEREARAKEQAERRKQQGQQRPQGNRNDRNDRRNNQNDRNDRNSQNRNDRRNRQEQGNQHRNQGQSQYNQQRQSFNQGPKIDFKARAAALKAEQNAEYARSSEERFKQAKANKEALREQNKRKEQAKLEDLFVEVESPKPTAKAPATPAPTAQDPAVDTRRKKQARPDKERDNFDHEEDGPRKQQKNRSSQNQVRNQKNSNWNNNKKTKKGKNNRNNNATPKPVTERKFHELPTEFEYTDGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGDTIELLMVDYGIEAKKKVEVDAADIERFFVEEGYINEDALEERPPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIVEGGKKITFLDTPGHAAFTSMRARGASVTDITILVVAADDGVMPQTIEAINHSKAANVPIIVAINKIDKPGANPERVIGELAEHGVMSTAWGGDSEFVEISAKFNQNIDELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAVATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNETPMAGDHFAVYEDEKAARAAGEERAKRALLKQRQATHRVSLENLFDTLKAGEVKSVNVIIKADVQGSVEALAASLQKIEVEGVKVTIVHSAVGAINESDVTLAEASNAVIIGFNVRPTPQARQQAESDSVEIRLHSIIYKVIEEVEDAMKGMLDPEYQEKIIGEALIRETFKVSKVGTIGGFMVISGKVTRDSKVRVIRDGVVIYDGQLASLKHFKDDVKEVTNGREGGLMIEGYNDIQVDDTIEAYIMEEIKK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_SALG2
Sequence: MSEQNAQGADEVVDLNNEMKARREKLAALREQGIPFPNDFRRDRTSDQLHAEFDAKEAEELEALNIEVSVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLPEGVYNEQFKKWDLGDILGAKGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGLQDQEARYRQRYLDLISNDESRNTFKTRSKILAGIRQFMVARGFMEVETPMMQVIPGGASARPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYKDLIELTESLFRTLAQDVLGTTQVPYGDEVFDFGKPFEKLTMREAIKKYRPETDMADLDNFDSAKAIAESIGIHVEKSWGLGRIVTEIFDEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFLDQVNAKAAGDDEAMFYDEDYVTALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_MAGSA
Sequence: MSKRVTVLMGGASAERDVSLRSGAAAAKALEQAGFEVALVDCDRNPAELVRAITETRPDVVFNALHGRFGEDGCVQGVLNLLGVPYTHSGLLASAAAMDKAFARALFASAGIPVAEGRVITRTDRNGPDPLPRPFVVKPLNEGSSVGVFIVRDNQPSPLPDWPFDADEVLVESFIPGRELTAAVMGDRALGVLEITSDHGFYDYEAKYAPGGSRHLMPAPIPEADYAEACRLAVAAHKALGCRGVSRADLRYDDTVPGQPPRLVMLEVNTQPGMTATSLVPEMAAYQGITFPELVRWMVEEARCD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_FERNB
Sequence: MRFSQFYAPTLKEAPADAEVPSQELLTRAGFIRKIAAGVYTYLPLGRRVLLKIEKIVREEMDNIGANEILMPIIQPAELWKQSGRWEDYGPEMMKLKDRHGRDFTLGPTHEELVTFLVQNELNSYKQLPITLYQMANKYRDEIRPRFGVLRAREFIMKDGYSFHSDWESLDETYKAHRKAYSNIMERIGLKYAVVEASSGAIGGNESHEFVAFADTGESNVLFCECGYAGNDERVPYTGEIIYDNEELKGMEKVYTPNVKTAQDVADFLGVPVRKIVKTLIYKGRNGYFMALVPGDRELNEEKLKNFLNDQSLAFATPDDILKDFGVPIGFLGPVGVKGIKVIADHLVKGMKNFVVGGMEKDYHFVNVNVDRDFKVDELADLIVTREGDPCPVCGKPLNAKKGIELGHIFKLGTKYSEAMGSKYMDKDGQLKPFIMGCYGWGVSRTLGAIVEQLHDEKGIIWPLSVAPFAVVITPVSNNENLMKFSEELYNFLVEKGEEVLLDDRNISPGMKFNDADLIGIPFRVTVGKALSEGMVEIKWRTGQQFKVKATLEEIYEFLQKSKQEYDPHKRVEK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_TREDE
Sequence: MAKKKVVTQIKLQCPAGKATPAPPIGPALGPHGVSAPQFVQQFNDRTKSMEPGLVIPVVITVYADKSFTFILKTPPASVLIKKACKIEKGSATSVTAKVGKLSKAALEEIAKTKMPDINANDIEAAKKIIAGTARSMGVEVER
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ATPE_ALKOO
Sequence: MASTFRLQIVTPSRTFYDDEVEMAIVRSTEGDLGIMSNHMLMVAPLKIGKVRIKKDGQFREAAISEGFVQVESEYTRIITDTAEWPEEIDVQRAEEAKERAEKRLSASQGEIDRLRAEIALKRALNRLSVANGK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RUVA_BRUME
Sequence: MIGKLKGVIDEIAEDHAVIDVHGVGYVAFCSARTLGNLGGAGEAAILFIETYVREDMIRLYGFATQLEREWFRLLQNVQGVGAKVALAVLGTLSPSELANAIALRDIAMVSRAPGVGKKVAERIVTELKNKAPAFAGEASGTIGLKQELGAGAAPAPVADAVSALSNLGYSRDQAANAVAAALKETGEGADSAKLIRLGLKELSQ
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RHVI1_ROSHC
Sequence: MDTSTSAYAPLPGEDPLFSGHPPASLRRSWKGFAVIFASVLFLLSLVGLIIHQGPQQPPDVMPDKQDEHHHPQSTTPASETTASWEPRGKALGVSAKSNPPVSDELSYNWTNAMFSWQRTAFHFQPERNWMNDPNGPLFYKGWYHLFYQYNPDSAIWGNITWGHAVSTDLIHWLYLPIAMVADQWYDANGVWSGSATLLPDGQIVMLYTGDTVDAVQVVCLAHPANLSDPLLLDWVKYSGNPVLTPPPGILTTDFRDPTTAWTGPDGKWRITIGSKVNTTGISFVYHTEDFKTYNMSKGVLHAVPGTGMWECIDFYPVAINGSKGVETSVNNPSVKHVLKASLDNTKVDHYALGTYFEENETWVPDNPGLDVGIGLRYDYGRYYASKTFYDQNKERRILRGWINETDTESDDLAKGWASVQTIPRTVLFDNKTGTNLIQWPVEEIEELRLNNTDFSDVLVEAGTVVELDIGTATQLDILVEFELEPLESSETVNSSVGCGGGAVDRGTFGPFGILVIADETLTELTPIYFNLANSTEGDVITYFCADERRSSKAPDVFKQVYGSEVPVLDGEKHFARVLRALRKEVGR
What is the function of this protein?
Acidic vacuolar invertase involved in light-induced bud burst (PubMed:22505690, PubMed:27083698).
What are the official names of this protein?
Acid beta-fructofuranosidase 1, vacuolar, Vacuolar invertase 1, RvVI1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 32 family.
What are the subcellular locations of this protein?
Membrane; Single- pass type II membrane protein. Vacuole lumen. Note=May be released into the lumen of the vacuole from the tonoplast through a proteolytic processing.
Protein: CYSI_SHEB9
Sequence: MSEQKLALNEYLKTDSDYLRGTIKEGLDSAVTGSFSDGDQQLIKFHGFYQQDDRDLRNERKEQKLEPLYSFMLRARVPGGICSPQQWLGVDKIASTLTSSNSIRLTTRQTFQYHGIPKRNLKTIIQDLDREALDSIAACGDVNRNVMCNPNPVESKLHEQAYAVAKQLSDHLLPHTRAYAEIWLDEEKLLSTEDETVEPVYGKTYLPRKFKMAVAVPPDNDVDVYTNDLGFIAVAENGELVGFNLTAGGGMGSTHGEVETFPRLADDFGFIKTEDVMKFAEAVMTVQRDWGNRVNRKRSRLKYTIVDHGYEKFKAEVELRAGVKFEPKRDVVIGDRGDRYGWVEGVDGKWHLTLFIESGRIKDLPGQTLQTGLREIAKIHKGDFRMTSNQNMIIAGVAAEDKATIEGLARKHGLLGQVLTQTRGHSIACVALPTCPLAMAEAERYFPEFIDHIDALQAKHGISEQAIVVRMTGCPNGCARPFAAEIGLVGKAPGRYNLYLGASFEGTRLNKMHRENIQEAEILAELDTLFGRYAVERDAGETFGNFTVRVGVVKAVIDAAKDFHG
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: TILS_SYMTH
Sequence: MPLLDRVREYVVRHGMLEPGDRVIVAVSGGPDSLALTHVLYRLAPAWRLSLHLFHLDHGLRGEASRADAAFVADLARELSLPLTTVTLRPGELEAMRGSLEDNARRRRYAEMARLAAAIGAQRAATGHNRNDQAETVLMRLLRGSGSTGLAGIPPVRREGGLTIIRPLLGASRQEILAYCRAHGLTPRMDATNLQGDFERNRIRLEILPALTERFGDAVVDNLAQTADLLREEDRLLAELTREACARCGWRETGEATGEPVVELDGTLLVQEPLALARRIVRMAVQRVSGSAYGPGLSAVTRALELAGRTEGSHWLDLPQGVRLSVAYGRCRFARSHPQLGPGAEALEQVWPVAVPGETAIPALGVTVAAELVPPSAMPARLPDDEMWLDRDRLPGPLAVRTRRPGDRLWPAGMQGSKKLQDILVDAKVPRDQRDGLPLLVAGDTVVWVPGVIRDRRFRPDAGTRSAVRVTVRRRPEGSGGD
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_ECO27
Sequence: MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSSIADKLQAGERDLDEIIAIAGQELNEKGFRSDDIQIRDADTLLEVSENSKRAVILVAAWLGDARLIDNKLVELA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIRB2_SALTY
Sequence: MTIAMLLTLHLICVALSVSLFVARYWWRYCGHALAAARWTRIVPPVIDTLLLLSGIGLIVKTHILPFTESGSWLTEKLFGVIIYIVLGFIALDYRQARSQQARFIAFPLALVVLYIIIKLATTKIPLLG
What is the function of this protein?
Required for maximal expression of sirC, not required to invade host cells.
What are the official names of this protein?
Protein SirB2.
What is the protein family that this protein belongs to?
Belongs to the SirB2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KPRS_VIBCH
Sequence: MPDMKLFAGNAIPELAQRIADRLYISLGDATVSRFSDGEVAVQINENVRGSDVFIIQSTCAPTNDNLMELVVMIDAMRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSNVGVDRVLTIDLHAEQIQGFFDVPVDNIFGTPVLLEDMKARNLEDPVVVSPDLGGVVRARATAKALGDIDIAIVDKRRPRANVSEVMNLIGDVEGRDCVIVDDMIDTGGTLCKAAEALKERGAKRVFAYATHAVFSGNAAKNIKNSVLDQVIVTDSITLSKEMAATGKVTQLTLSSMLAEAIRRISNEESISAMFN
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX9A_STIHA
Sequence: XIIGAPCRRCYHSDGKGGCVRDWSCGQQ
What is the function of this protein?
Kappa-stichotoxin-Shd1b: inhibits voltage-gated potassium channels (Kv).  This toxin inhibits the binding of 125I-alpha-dendrotoxin to synaptosomal membranes (IC(50)=270 nM).
What are the official names of this protein?
Kappa-stichotoxin-Shd1a/kappa-stichotoxin-Shd1b, Kappa-SHTX-Shd1a/kappa-SHTX-Shd1b, Kappa-AnmTX Sha 9a-1, Potassium channel toxin SHTX I/SHTX II, Potassium channel toxin SHTX-1/SHTX-2.
What is the protein family that this protein belongs to?
Belongs to the sea anemone structural class 9a family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: LIGB_SALDC
Sequence: MRLWKSMAWGILLWHSQSGALCPAWPPARAAEEITRLQQQLADWNDIYWKQGVSAVDDSVYDQLSARLVQWQRCVGQDVSSTPVSPPLNGTTMHPVAHTGVRKLADRQAVEQWMRGRSELWVQPKVDGVAVTLVYQNGKLTRAISRGNGLQGEDWTPKIRLIPSIPQTTQGALANAVLQGEIFLQREGHIQQRMGGMNARSKAAGMLMRQDNASALNSLGIFIWAWPDGPANMPERLSQLAKAGFSLTKKYSLAVKDASEVERARQSWLTSALPFVTDGVVIRMAKEPASQYWRPGQGDWLAAWKYPPVAQVAQVSAIQFSVGKSGKITVVASLVPVILDDKRVQRVNIGSVKRWEAWDIAPGDQILVSLAGQGIPRLDEVVWRSRERSKPVPPDSHFNSLTCFYASETCQEQFISRLVWLGSRSALGLDGMGEASWRALHQTHRFEHIFSWLALTSAQIANTPGFAKGKSEQIWRQFNLARRQPFTRWIMAMDIPLTQAALQASGDRSWEQLLMRTEQHWRQLPATGERRAGRVIDWRDNPQIKTLSRWLAAQHIPGFGS
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
Protein: DGTP_SHIBO
Sequence: MAQIDFRKKINWHRRYRSPQGVKTEHEILRIFESDRGRIINSPAIRRLQQKTQVFPLERNAAVRTRLTHSMEVQQVGRYIAKEILSRMKELKLLEAYGLDELTGPFESIVEMSCLMHDIGNPPFGHFGEAAINDWFRQRLHPEDAESQPLTDDRCRVRGLRLRDGEEPLNELRRKIRQDLCHFEGNAQGIRLVHTLMRMNLTWAQVGGILKYTRPAWWRGETPETHHYLMKKPGYYLSEEAYIARLRKELNLALYSRFPLTWIMEAADDISYCVADLEDAVEKRIYTLEQLYHHLHDAWGQHEKGSLFSLVVENAWEKSRSNSLSRSTEDQFFMYLRVNTLNKLVPYAAQRFIDNLPAIFAGTFNHALLEDASECSDLLKLYKNVAVKHVFSHPDVERLELQGYRVISGLLEIYRPLLSLSLSDFTELVEKERVKRFPIESRLFHKLSTPHRLAYVEAVSKLPSDSPEFPLWEYYYRCRLLQDYISGMTDLYAWDEYRRLMAVEQ
What is the function of this protein?
dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase, dGTP triphosphohydrolase, dGTPase.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 1 subfamily.
Protein: Y4OW_SINFN
Sequence: MRRESKQMTIFRSGDQPPGWCELTDFEFVDLTDQPLPIPLAAEKQRLLVTSGSCCVRSAEGAQVLSEGQFLDMDGANGPFTADAGEGAAQVLVFYGRWGNELGGCGVFKLGPDTPVPVRGDPVNYPKSTNFDSHYHDCDEYWVIIEGAGTVVVGSRSFEVEVGDCVAIGMGHHHDLSEVWSDVKGAYFETTLEGRKRFGHLWEHTHGPADVRPERV
What are the official names of this protein?
Uncharacterized protein y4oW.
Protein: RLMN_HAEIE
Sequence: MCNNEAKMSELLSVQSDAPAKKINLMDLTRQQMREFFKELGEKPFRADQLVKWIYHFGEDNFDNMTNINKKLREKLKAVAEIKAPEVAVEQRSADGTIKWAMQVGEQQVETVYIPEADRATLCVSSQVGCALACTFCSTAQQGFNRNLTVSEIIGQVWRASKIIGNFGVTGVRPITNVVMMGMGEPLLNVANVVPAMEIMLDDFAYGLSKRRVTLSTSGVVPALDNLSKMIDVALAISLHAPNDELRDEIVPINKKYNIKTLIDSVNRYLTVSNANHGKVTIEYVMLDHVNDGVEHAHQLADVLKNTPCKINLIPWNPFPEAPYAKSSNTRIDRFQKTLMEYDFTVIIRKTRGDDIDAACGQLAGDVIDRTKRTAMKRQFGQNIGVTEVN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P12_ASFWA
Sequence: MALDGSSGGGSNVETLLIVAIIVVIMAIMLYYFWWMPRQQKKCSKAEECTCNNGSCSLKTS
What are the official names of this protein?
Inner membrane protein p12, Protein p12.
What is the protein family that this protein belongs to?
Belongs to the asfivirus inner membrane protein p12 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Note=Part of the virion inner membrane.
Protein: M2_I79A8
Sequence: MSLLTEVETHTRSGWECRCNDSSDPLVIAASIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTEGVPESMREEYQQEKQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: ACPS_PHOPR
Sequence: MAIIGLGTDIADIERVDKVFARSGDAFAERILAPSELVIYHSLKLKARYLAKRFAVKEAASKALGTGIACGVSFQDFIVSNDERGKPLLSLSGKAAELAESMGVKHVHLTLADEKRYAVATVILES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.