PharMolix/UniProtQA huggingface dataset:
Protein: TAF1B_DROME
Sequence: MEEVLETMQLENMHCDVCEGTTFQEREGFYYCVECGTQKDQIRAVDITAEDNFDDTAAGRYTARTIRQKKDTEKEDEDDITSWEFYNYVLRGFLQELLNMGAKPELKLMTLQVWAAYLDSMEVAFSKSNKTGLPKLNVRALPIDARIIYNHKTFKKGKKGKKSTLTGDPNDERAKFRLWNRTKRNLDASGYRSHGGASESEGEQSLHLQWSMRARKSLKRHMPLKHLDKHSRDSKGSMSCHSLRPRVKQLHNFDRNIYCLNIIKLYVVLGIALNMVEDDIQLSDLLRFIDEEHLTKRCMLNYLPGNVAAKGKALLKDMELSKMKDKVTNKLLRVNIACMSRFINLSEYQKPNLHSLAERYILELALPPRLLKYVNSLLDLHPPTFFNAMTVHPYPRYEARTMAYILYAMKLLFGLDDLKERNISESAAKINEKLLEVGGDEAPLLFVFTEWMEFVEMRKVIVSHYNQSFARRFGVSTRTGCQVDDILAKEWKEKEQGETFGWMQGSAAMKRQHENLTHIIETMLKDHFGESSKESMEKEHIEFQPSLTPAHSYFNRILLQVSRSDGAKMKITIPDHMKVDHSARNLDPFVLETTELSQYLSQHGLKLRVEELACQEDIQNVGIFRPLTIIRGDGREYRANTEIKTETWISELKRKEKRPDFRFTQPTGTYGARYLKRITMRDARRVQLEINNPFWDVTETPSFLLKLNDNEIPLDSLSSLQTFEEGTMDPLNIPLDLPRRNLEKILNPEGSDRASDQVASDINDEPPSPETLLLQVSNFDCWLLHGYMKRIRRHDKHELRQLFPCSFRWLLETCASTIGIVWEELYEELLIVEVMYHHSIRDWSNHRNYLCIQHNTQEKDIRTLARTYKELW
What is the function of this protein?
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription.  Binds rDNA promoters and plays a role in Pol I recruitment (By similarity).
What are the official names of this protein?
TATA box-binding protein-associated factor RNA polymerase I subunit B, TATA box-binding protein-associated factor 1B, TBP-associated factor 1B.
What is the protein family that this protein belongs to?
Belongs to the RRN7/TAF1B family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL23_NATTJ
Sequence: MDPRDVIIKPWITEQSTDQMEENKYTFVVAKDANKTQIKDAVQKLFGVKVKQVNTMNMKGKPKRLGIYQGKTPSWKKAIITLTDDSKAIDLFE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PUR9_XYLFA
Sequence: MASDFLPVHRALLSVSDKTGLVELARALLAYNIELLSTGGTATIIREAGLPVQDVADLTGFPEMMDGRVKTLHPMVHGGLLGRAGIDDAVMAKHGIAPIDLLILNLYPFEQITAKKDCTLADAVDTIDIGGPAMLRSAAKNFARVAVATSPDQYPDLLAELQAHHGQLSAEKRFALAVAAFNHVAQYDAAISNYLSSVSDMHTTLPLRHEFPAQLNNTFVKMTELRYGENPHQTGAFYRDVHPQPGTLATFQQLQGKTLSYNNLVDADAAWECVRQFEAPACVIVKHANPCGVAVGKACSDAYEEAYATDPTSAFGGIIAVNRMLDVATMQSILDRQFVEVLIAPDYDADALAYATKKANVRVLRIPSTGVMNRYDFKRIGSGLLVQSTDSLNIHSDALKVVTQLAPTDAQQRDLLFAWHVAKYVKSNAIVYAKDNRTIGIGAGQMSRVYSARIAGIKAADAHLAVTGSVMASDAFFPFRDSIDAAAAAGIKAVIQPGGSMRDNEVIAAADEHGIAMVFTGIRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: RFOX2_HUMAN
Sequence: MQNEPLTPGYHGFPARDSQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY
What is the function of this protein?
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements.  Prevents binding of U2AF2 to the 3'-splice site.  Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity).  RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.
What are the official names of this protein?
RNA binding protein fox-1 homolog 2, Fox-1 homolog B, Hexaribonucleotide-binding protein 2, RNA-binding motif protein 9, RNA-binding protein 9, Repressor of tamoxifen transcriptional activity.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: A3AEM_PHYIT
Sequence: MRLAIMLSATAVAINFATSSAIDQTKVLVYGTPAHYIHDSAGRRLLRKNEENEETSEERAPNFNLANLNEEMFNVAALTERADAKKLAKQLMGNDKLADAAYMWWQHNRVTLDQIDTFLKLASRKTQGAKYNQIYNSYMMHLGLTGY
What is the function of this protein?
Multifunctional effector that can suppress host BAK1/SERK3-mediated immunity through at least two different pathways (PubMed:19794118, PubMed:20457921, PubMed:21348873, PubMed:26348328).  Manipulates plant immunity by targeting and stabilizing host E3 ligase CMPG1.  By preventing the normal 26S proteasome-dependent degradation of potato CMPG1, and thus potentially of its protein substrates in the host cell, Avr3a further abolishes host cell death during the biotrophic phase of infection (PubMed:19794118, PubMed:20457921, PubMed:21348873).  Associates with and affects also the function of the dynamin-related protein 2 (DRP2), a plant GTPase involved in immune receptor-mediated endocytosis (PubMed:26348328).  The Avr3a(EM) form evades recognition by R3a, thus does not trigger R3a-mediated hypersensitivity and does not suppress INF1-induced cell death (PubMed:15894622, PubMed:16965554, PubMed:19245321).
What are the official names of this protein?
RxLR effector protein Avr3a, Avirulence protein 3a.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm.
Protein: RCF1_ASPNC
Sequence: MSEPLPSSFEEHPQFQEETSLQKFRRRLKEEPLIPLGCAATSYALYRAYRSMKAGDSVEMNKMFRARIYAQFFTLIAVVAGGMYYGSERKQRREFEQMVEARKSQEKRDAWLRELEIRDKEDRGWRERHAAIEAAANEAANAKKSFPEQDAARSAIEPSEQKSIGVLIAVKELLSRQ
What is the function of this protein?
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
What are the official names of this protein?
Respiratory supercomplex factor 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RCF1 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: RL4_STRPQ
Sequence: MANVKLFDQTGKEVSSVELNDAIFGIEPNESVVFDVVISQRASLRQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLPQKVRRLALKSVYSAKVAEDKFVAVEGLSFAAPKTAEFAKVLSALSIDTKVLVLVEEGNEFAALSARNLPNVTVATAATASVLDIVNADKLLVTKEAISTIEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: HBA1_XENLA
Sequence: MLLSADDKKHIKAIMPAIAAHGDKFGGEALYRMFIVNPKTKTYFPSFDFHHNSKQISAHGKKVVDALNEASNHLDNIAGSMSKLSDLHAYDLRVDPGNFPLLAHNILVVVAMNFPKQFDPATHKALDKFLATVSTVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1, Alpha-1-globin, Hemoglobin alpha-1 chain, Hemoglobin alpha-major chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PDXY_PSEF5
Sequence: MKRTPHLLAIQSHVVFGHAGNSAAVFPMQRVGVNVWPLNTVQFSNHTQYGQWAGEVLAPQQIPELVEGIAAIGELGNCDAVLSGYLGSAAQGRAILSGVARIKAVNPKALYLCDPVMGHPEKGCSVPAEVSDFLLDEAVAMADFLCPNQLELDSFCGRKPQSLFDCLGMARSLLDKGPRAVLVKHLDYPGKLVDGFEMLLVTADGSWHLRRPLLAFPRQPVGVGDLTSGLFLARVLLGDSLVAAFEFTAAAVHEVLLETQACASYELELVRAQDRIAHPRVRFEATPIGF
What is the function of this protein?
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxal to PLP.
What are the official names of this protein?
Pyridoxal kinase PdxY, PL kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxY subfamily.
Protein: HCY2_HOMAM
Sequence: GADVAHKQQSVNHLLYLVTSHYPSLDYSLL
What is the function of this protein?
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
What are the official names of this protein?
Hemocyanin subunit 2.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family. Hemocyanin subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: KDSB_AROAE
Sequence: MAAFHVVIPARHASSRLPGKPLADIAGKPMVVRVLEQARRAGAASVWVATDHPEVLDAVRAAGGDALMTREDHPSGTDRLAEVVDALGWKADDIVVNVQGDEPLIEPKLIAAVAQALADDPVAAIATAAHPLHAAAELFNPNVVKVVCDAHDHALYFSRAPIPWARDAFATARDDIPAGLPVLRHVGLYAYRVAFLRCYASLAPSPLEQWEALEQLRALWHGHRIRVMTVAVAPAAGVDTPEDLERVRAAFDRHERVG
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_GEOUR
Sequence: MDKLIIKGGKKLAGEVTVSGSKNASLPIFISTILAPAEHEISNVPFLRDINTTIKVLEQLGAKVDGNGNIVKIDTTGVDNFEATYELVKTMRASVLVLGPLLARFGKARVSLPGGCAIGARPINLHLKGLAAMGADINLTHGYVEAKAKQLKGARINFDVSTVGGTEHLMMAAATAKGETILENAAREPEIVDLANVLTKMGARIDGAGTDTIRISGVKELGPVSHRVMPDRIEAGTFMIAAAITGGDIKVRNMQLEHLDALVFKLQDAGVEIINKDNVVRVKGPRKIKGVNIKTRPYPGFPTDMQAQFMALMCLADSASVISENIFENRFMHVSELMRFGADITTEGNTATVKGVKKLSGAPVMATDLRASACLILAGLAADNTTEVSRIYHLDRGYESIEKKLAGLGADIVRVQE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIGLN_PONAB
Sequence: MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPAGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDERAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVSVTQEHIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARVIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLDNVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKGCVEAAKKRIQEIIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQITRDFSVQIKFPDREENPVHSTEPAVQENGDEAGEGREAKDSDPGSPRRCDIIIISGRKEKCEAAKEALEALVPVTVEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAITGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRLEHDVNIQFPDKGDGNQPQDQITITGYEKNTEAARDAILRIVGELEQMVSEDVPLDHRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLADVVDSEALQVYMKPPVHEEAKAPSRGFVVRDAPWAASSSEKAPDMSSSEEFPSFGAQVAPKTLPWGPKR
What is the function of this protein?
Appears to play a role in cell sterol metabolism.  It may function to protect cells from over-accumulation of cholesterol (By similarity).
What are the official names of this protein?
Vigilin, High density lipoprotein-binding protein, HDL-binding protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ACDH_BURP1
Sequence: MKSKSSRTRVAILGSGSIGLDLMFKVKASEQFDLKFVVGRNANSDGLRLARSCNVETSSDGLDFLKAHEDAYDLVFDATSAAAHKVNNRFFSDAGKFVIDLTPAKVGRLCVPCINLDDMGAEQNVNLITCGGQASLPLAYALKQAVDEIDYLEVVSAIASRSAGIATRENIDEYMTTTEYALAKFSGAKKTKAILNINPAEPGVRMQTTLYAYARYRDFDRVRASVADMVEKVREYVPGYRLVVEPLESQGRITIGLTVRGRGDYLPEYAGNLDIINCAALAVASHRHATARLGATQ
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: CDII_YERPE
Sequence: MKNLLYVVLLMAVCILGLLIVGTIFYLFLEVFMYFYVNAPISLESFQFTRLLKMSIYGGGILGLGIGLLRIFKIKGF
What is the function of this protein?
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system.  CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion.  Protects cells against the CDI activity of CdiA, its cognate toxin protein, but not against non-cognate CdiA from E. coli strains 563, EC93 or D. dadantii strain 3937.
What are the official names of this protein?
Immunity protein CdiI.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TX1AB_ECTTU
Sequence: WSTIVKLTICPTLKSMAKKCEGSIATMIKKKCDK
What is the function of this protein?
Algogenic for animals, human and insects (PubMed:7826413).  At high concentrations (0. 5-1 uM), it acts as a pore-forming protein that forms nonselective cation channels both in cell and artificial membranes (PubMed:7826413).  It is weakly selective for cation over anions channel conductance is identical in both directions.  At lower concentrations (1-10 nM), this heterodimer inhibits cardiac L-type calcium currents in isolated rat cardiac ventricular myocytes (PubMed:10336635).
What are the official names of this protein?
Omega/M-ectatotoxin-Et1a subunit B, Omega/M-ECTX-Et1a subunit B, Ectatomin subunit B, EA, Ectatomin-Et1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the ectatomin family. Ectatomin-Et subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: F16PA_LEPIC
Sequence: MSVHPTQTLSLSQYLIEEQLKLPQATGDFTALMSHLVYAAKIVSREVRKAGLLENILGATETVNVQGETQMKLDEYADKVFNHTLTRSGHLCILGSEEHEETVPVPNGYKIGKYTIAIDPLDGSSNIDANVSIGTIFSVHLRKSPAGTPGTLSDLLQQGSGQRAAGYVLYGSSTMLILCTGKGVSGFTLDPSCGEFILSHPDMQIPETGGIYSINEGNYNYWSDEVKNYIRDIKSIEGGRKPQSGRYIGSLVADFHRNLLKGGIFLYPNDTKSTKYPNGKLRLLYEAAPMAFIAEQAGGMAVTVYGERILDLTPKELHERTTLVVGSKKEVEHFLKFAPKKS
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_MELID
Sequence: MKEYQVYLERARSRQQDFLYPLIFREYIYGLAYSQNFNRSIFVENLGYDNKYSLLIVKRLITRMYQQNHLIISANDSNKNPFLGYNKNFYSQIISEGFAIVVEIPFFLELSSSLEEPEIIKSYKNVRSIHSIFPFLEDKLTHLNYVSDIRIPYPIHLEILVQILRYWVKDAPFFHLLRLFLYNFCNWNSFITTKKSISTFSKSNPRLFLFLYHFYVCEYESIFLFLRNKSSHLRLKSFSVFFERIFFYAKREHLVEVFAKDFSYTLTFFKDPLIHYVRYQGKCILASKNAPFLMNKWKHYFIHLWQGFFDVWSQPRTININQLSEHSFQLLGYFLNVRLNRSVVRSQMLQNTFLIEIVSKKLDIIVPIIPLIRSLAKAKFCNVLGHPISKPVWADSSDFDIIDRFLRICRNLSHYYNGSSKKKSLYQIKYILRLSCIKTLACKHKSTVRAFLKRSGSEELLEAFFTEEEEILSLIFPRDSSTLHRLNRNRIWYLDILFSNDLVNDE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YVGM_BACSU
Sequence: MALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAWMSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWWAAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLTGSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISFLMLFFIQQKKTH
What is the function of this protein?
could be part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Putative molybdenum transport system permease protein YvgM.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLHD_ECO7I
Sequence: MGIMHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITQLTQDSRVDDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMP3_RABIT
Sequence: MKTLPTLLLLCVALCSAYPLDGASRDADTTNMDLLQQYLENYYNLEKDVKQFVKRKDSSPVVKKIQEMQKFLGLEVTGKLDSNTLEVIRKPRCGVPDVGHFSTFPGTPKWTKTHLTYRIVNYTPDLPRDAVDAAIEKALKVWEEVTPLTFSRKYEGEADIMISFGVREHGDFIPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHELGHSLGLFHSANPEALMYPVYNAFTDLARFRLSQDDVDGIQSLYGPAPASPDNSGVPMEPVPPGSGTPVMCDPDLSFDAISTLRGEILFFKDRYFWRKSLRILEPEFHLISSFWPSLPSAVDAAYEVISRDTVFIFKGTQFWAIRGNEVQAGYPRSIHTLGFPSTIRKIDAAISDKERKKTYFFVEDKYWRFDEKRQSLEPGFPRHIAEDFPGINPKIDAVFEAFGFFYFFSGSSQSEFDPNAKKVTHVLKSNSWFQC
What is the function of this protein?
Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans.  Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9.  Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway.  Acts also intracellularly.  For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage.  In addition, plays a role in immune response and possesses antiviral activity against various viruses.  Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities.
What are the official names of this protein?
Stromelysin-1, SL-1, Matrix metalloproteinase-3, MMP-3, Transin-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: ACP_ACIC1
Sequence: MALSKEEILTGLAEIINEVAGIPTSDVQPEKSFTDDLDVDSLSMVEVVVAAEEKFGVRIPDDEVKNLKTVGDAVDYIANATVSA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPX_ALKCK
Sequence: MVTLLTSPSCTSCRKAKAWLEEHDIPFEERNIFASPLSVEEVKQVVRMTEDGTDEIISTRSKVFQELDVELESLPLQKLFTIISDNPGLLRRPIIFDEKRLQVGYNDAEIRRFLPRKVRTFQLQEAQRLVN
What is the function of this protein?
Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes.  Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP).  This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
What are the official names of this protein?
Global transcriptional regulator Spx.
What is the protein family that this protein belongs to?
Belongs to the ArsC family. Spx subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M1_I67A0
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRAIGTHPSSSTGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: GPA14_CAEEL
Sequence: MAFSCFDKFSYTYCYQCMHGPDGCMVPSRNGEGTELYAHSEELEAKLRELARRGHMEIEKELALEKKTYGSHIKILILGGPLSGKSTIFKQMQIIHVDGFKTDQELIQYRGLIDNNIRDIYLQLIAGSRVVGIPLDPIEHITYEIDEIYAPMSDAFSVRTISELLEPLTEFWNSKQIQEIYKRRCEFELLDSTKYYLENLTRIADPTYLPNQEDIVHSRKATMSINSIVFEYTGVSLLMIDVGGQRSERKKWLHLFDDAKVVLFVIDLTGYAKRSEESRMELSRFPKFFRDVGSNAYDMKVALKIFNEVAAASALANAVFLLFFNKVDLFKEILSQVNLQPCFSKFDGENTYEETSKYICEKFIRAASSKKSVFPHFTTATNTENVKLVFRACMESVFKANAKATGLS
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  In association with the G-protein coupled dopamine receptor dop-2, modulates two types of learning: touch habituation and chemosensory associative conditioning (PubMed:23607404).
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-14 subunit.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: TUSD_YERPA
Sequence: MSALKYCLLVTGPAYGTQQASSAYQFAQAVVGAGHHLVSIFFYREGVLNANQLTAPASDEFDLVRAWQQLAAEQAVTLNVCVAAALRRGITDQHEAEQLNLAAANLQPGFTLSGLGALAEATLTCDRMVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXJ_PSYA2
Sequence: MTATAQILPNTLEQNSDNISKKPLLGVNVDHVATLRQARGVSYPSPLAAALLCEKAGADGITIHLREDRRHIQDADVYEMAGQLTTRMNLEMAATTEMLEIACRVKPYWVCLVPEKRAELTTEGGLDVAGQLDLLKDYVAKLQAAGIKVSLFIDPEDKQINAAVTCGADAIELHTGSYAEAGLAGDIEKGSVELERIKTAVITAKRIDSKLLVNAGHGLTHDNVNAIAQIDGIYELNIGHALIADALFVGIEQAVIMMKIAMHR
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.