PharMolix/UniProtQA huggingface dataset:
Protein: TYSY_MYCTO
Sequence: MSIVTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GYRA_KOSOT
Sequence: MPEEIISRSINDEMITSYMLYSMSVIVGRAIPDVRDGLKPVQRKILFGMLELGLRHNQSYKKSARIVGEVMGKFHPHGDMAIYDALVRMAQPFSMRYPLIQGQGNFGSIDRDPPAAMRYTEARMQRLAEELLADIDKNTVKMIPNFDGSLIEPEVLPAKAPNLLMNGASGIAVGMMTNIPPHNLSELVEALTALIDNPDATIEELMEYVKGPDFPTGGIIMGRDGIKKMYETGRGRMVVRGVAEIEEAKGGTRIVISEIPYGVSKADLIQQIANVAQNVRDIQVRNVRDESDKRGLRVVIELKRGADPNVVLNLLYKHTQLQTTFGAHMLVIDEKKRPKLMNLKEIFQAFIKHRYEVVKRRTEYELEQASKKAHILEGLTKASRAIDTVVDIIRNSKNIQEASVNLQETLEITPEQSQAILEMRLGKLTALEIDKLVTEYAELVEKIKEYREILSDDKNIYQIIKKELQELEAQYGDARRTKISIDGNTDFNVEDVIPDDEVVVTVTKKGYIKATPLEDYRKQGRGGKGIRGVKTTDADFVTNVVSTTRLSKTVVITSKGKAYFINNYELECTSRSSRGKLLANYVKIEPDETVQAVLSVKREEVANKHLIITTRKGKIKRTPFEAFINSRTSGIKAITLNEGDSVVDAGISTSEEETIIISTRKGMVIRFPISQIRPMGRTAAGVKAMALRGDDEVVSATIVLPVDERYLFTATERGVGKRTPLSEYRPQHRAGMGVKNIYGLERTGYVVGSLVVTNEDEIIVITKNGMSIRIPAADIRPTGRVTKGVKVVELRDDDTVASLAVVVDQAEV
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_STRM5
Sequence: MGQSVVVLGAQWGDEGKGKIVDLLTEEIGAVVRFQGGHNAGHTLVINGKKTVLHLIPSGILRDDALCLIGNGVVISPAALQKEIAELETSGVEVRSRLKISPAAPLIMPYHIALDQARERAAGGKAIGTTGRGIGPAYEDKVARRGIRIADLHYPKQLEELLRTALDYHNFVLTNYLKTDAVDFQKTFDEALAFGEYVQPMKSDVAGILHDLRKQGKRVLFEGAQGALLDIDHGTYPYVTSSNTTVGGALAGAGVGADSIDYVLGIAKAYATRVGGGPFPTELDDEIGQGIRDRGAEYGASTGRPRRCGWMDIVALKRAVAINGISGLCITKLDVLDGMEKLKVCIAYEYNGKRTEYAPLDAQGWEECTPVYLEFPGWTENTHGITNWDDLPPAARAYLRSLEELAGCPISIVSTGPDRDHTMVLQDPFA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRC3_EMENI
Sequence: MMKRKADRQTAAAAPVSAFAARKARLQQTQTQVQTVVASEKTTHTDVAAEPPSKRPRRSLQESQAQSTSEEDTKRTSKRSAAKTEKVQRVDSGTITRTRETRMKDSEIEVEDLEKERSSNEESEGEDAVEENAAGVVAVPAAEDGYESPADNTMTVVFPLSKIRLNKNNIVYSDEDTLCVRIQEKLSIVLIGQYDLWVKRGVVSVMGAKLHPSPRVYRVYAPSTHSLPVIKCVTGVNGAAEVEFKSCHSGITRLRDLSPLYQRLWNSGNTPADKLSLKAVGQDARRTFSVLHTSADDPLKRHLRPLHLEKQWSAAIKVLSQRAGRLQVLICGPKASGKSTFGRYLLNHLLSPAPQPELNYTNTDGVAFLDLDPGQPEFLPMGQVYLAHLRSPVFGPPFTHPSLNNEREGTIIRAHHIGATSPKEDPDHYVLAAANLMEQYRTLLATYPQCPLIINYPGWIFGLGLEVATYLIQSLGLSDVVYMSEKGPTEVVEPLSQAASLARVSLTILPSQPTEFVSRSSAQLRSMQMQSYFHMAQPAGVSHPTWLENPVSKNRPFRVRYAGENRGVHGVMTLDSQIIPDLLCESLEGALVGVVAIESPNALPIPSSNAPPANEEEATSNADDDVDMENETEHNRNATISHLTTLTISTKESLPYITSGPGTSTPLHPSSSSMLGLALIRSINPDTQTLDLVTPIPSTRLIQSLERGHALVLVRGVLDNPNWAVAEEYYAARAEERRVRRGIRGRKEAGVGEQGDESVEQRLLGLLKERIRRAKDVPFMTVVEDHGRRKQEEAAQRALWKLRKKAGIESEDEVGY
What is the function of this protein?
Polynucleotide 5'-kinase involved in rRNA processing.
What are the official names of this protein?
Polynucleotide 5'-hydroxyl-kinase grc3.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. NOL9/GRC3 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RD15_PHYIT
Sequence: MMKSLYAVNLVLLLLLAFFAPAPATRELNMRAAPSDSTRVVDYATTERLLRAHSSDKEEQKEEEERAISINFSSLEKIFKKVTSAKTTELQGMLKADEALGSAFKTLKLGTMRIGKDGSVDPKMVAKFLSSRNFKIWSQHAVKINKDDPYGEMLKALTNVFGEKNVAMMILVGNLSRNSRDVAKKLEKAQFYKWYFVDKYKTADEVFTNVLKADRNRIHGYGREKEIWGDYAKYVTTTVMKY
What is the function of this protein?
Effector that enhances P. infestans colonization of Nicotiana benthamiana leaves.
What are the official names of this protein?
RxLR effector protein PexRD15.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane.
Protein: NCS1_PONAB
Sequence: MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIGFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV
What is the function of this protein?
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner.  Directly regulates GRK1 (RHOK), but not GRK2 to GRK5.  Can substitute for calmodulin (By similarity).  Stimulates PI4KB kinase activity (By similarity).  Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity).  May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).
What are the official names of this protein?
Neuronal calcium sensor 1, NCS-1, Frequenin homolog.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
What are the subcellular locations of this protein?
Golgi apparatus. Postsynaptic density. Cytoplasm, perinuclear region. Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane; Lipid-anchor. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.
Protein: CYNS_POLSJ
Sequence: MNRNDITEKIITTKVAKGITWESVAKKVGLSKEWVTAGCLGQMTFDEKQAKVVGKIFGLTAEEQKWLQVVPYKGSLPTPVPTDPLIYRWYEIVSVYGTTIKELIHEEFGDGIMSAIDFSMDIVRQPDPKGDRVNVVLSGKFLPYKTY
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: RS10_LAWIP
Sequence: MTTVSSDRIRIKLKAYDYRILDKAVAEIVDTARNTGASIAGPIPLPTNIHKFTVNRSVHVDKKSREQFEMRIHKRLMDILEPTQQTVDALGKLSLPAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: NANA_SALTY
Sequence: MAKALQGVMAALLTPFDHQQQLDSESLRRLVRFNIGQGIDGLYVGGSTGEAFVQSLAEREQVLEIVAEEAKGKITLIAHVGTVSTAESQQLASAAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVSALKQTSGDLFQMEQIRRAHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVQALREGDVAKAQRLQTECNKVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFAPVDEKYLPALKALAQQLMEEKA
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METAS_BRAJP
Sequence: MTLLFDGDRRIKSPALAPAGGDRRARDPIELTIGLVNNMPDSALKATDVQIARLLQQAAPWHVRIRLHCFSLPSIARSPMASSHVAQTYTDIDRLDGLDIDGLIVTGAEPVAARLRDESYWPDLAAIVDWARTNTKTTIWSCLAAHAAVLHLDDIERQRLASKCSGVFDCVKVRDDWLTHGIDAPLQVPHSRLNAVNEPLLAERGYDILTRSAEVGVDIFARTMPSRFVFFQGHPEYDALSLQREYMRDIARYLAGQREDYPRPPRSYFSAESEAVLNTFEIRARARRDPTLAAELPGLTLRPDLAAGHAAKLLFRNWIGYLADG
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_CYTH3
Sequence: MVNKNSPKTIDRIILGVDPGTNVMGYGLIAIKGTQLTLIQFGVIHLSKYTDHAIKLSKIFERISLLIEEYHPDEMAIEAPFFGSNVQSMLKLGRAQGVAIAAAISKQVPIFEYAPKKIKQSVTGSGNASKEQVAAMLSKILFFQEIPKLLDATDALGVAVCHYFQKGDVKKSKGGWNNFIKENPDKVKTVPAKISKKKTD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: LEAP2_PIG
Sequence: MWHLKLFAVLVICLLLAVQVHGSPIPELSSAKRRPRRMTPFWRAVSLRPIGASCRDDSECLTRLCRKRRCSLSVAQE
What is the function of this protein?
Has an antimicrobial activity.
What are the official names of this protein?
Liver-expressed antimicrobial peptide 2, LEAP-2.
What is the protein family that this protein belongs to?
Belongs to the LEAP2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_STRPM
Sequence: MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNSHIKEHKKDHATYRGLMKKIGHRRNLLAYLRRTDVNRYRELIQSLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RS12_BACCN
Sequence: MPTINQLVRKGRTDKVWKSKSPALNKGFNSLKKKSTDISAPQKRGVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTAGVDKRMQGRSKYGTKKPKAAKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RRT14_YEAS2
Sequence: MSSSLSQTSKYQATSVVNGLLSNLLPGVPKIRANNGKTSVNNGSTAQLIDRNLKKRVQLQNRDVHKIKKKCKLVKKKQVKKHKLDKEQLEQLAKHQVLKKHQQEGTLTDHERKYLNKLIKRNSQNLRSWDLEEEVRDELEDIQQSILKDTVSTANTDRSKRRRFKRKQFKEDIKESDFVKDHRYPGLTPGLAPVGLSDEEDSSEED
What is the function of this protein?
Involved in ribosome biogenesis, probably through modulation of rDNA transcription.
What are the official names of this protein?
Regulator of rDNA transcription 14.
What is the protein family that this protein belongs to?
Belongs to the RRT14 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL28_STRP6
Sequence: MAKVCYFTGRKTVSGNNRSHAMNQTKRTVKPNLQKVTILVDGKPKKVWASARALKSGKVERI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RL1_CAMC5
Sequence: MGKTTKRFQELLKKVEENKIYNLDEAITTIKTLASAKFDETVEIALKLNVDPRHADQMVRGSVVLPAGTGKTVRVAVIAKDAKADEAKAAGADIVGSDELVEDIQKGIMNFDVLIATPNLMGLVGKVGRILGPKGLMPNPKTGTVTMDVAQAVNNAKSGQVNFRVDKQGNIHAGLGKVSFSKEQLNENISTFIKAINKHKPSASKGRYVKNASLSLTMSPSIALDTQEVMDLK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: LIPB_KLEP7
Sequence: MQHNKILIRQLGLQPYEPVSQAMHEFTDARDEDTLDEIWLVEHHPVFTQGQAGKAEHVLVPGDIPVIQSDRGGQVTYHGPGQQVMYVLLDLKRRKLGVRELVTLLEQTVVNTLAEYSIESHPRADAPGVYVGERKICSLGLRIRKGCSFHGLALNIAMDLTPFLRINPCGYAGMEMTQMRQWQPAASPETVAPRLVANLLALLNHPPHEYLPRD
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BODG_PSESK
Sequence: NAIADYRTFPLISPLASAASFASGVSVTWADGRVSPFHNLWLRDNCPCGDCVYEVTREQVFLVADVPEDIQVQAVTIGDDGRLVVQWDDGHASAYHPGWLRAHAYDAQSLAEREAARPHKHRWMQGLSLPVYDHGAVMQDDDTLLEWLLAVRDVGLTQLHGVPTEPGALIPLAKRISFIRESNFGVLFDVRSKADADSNAYTAFNLPLHTDLPTRELQPGLQFLHCLVNDATGGNSTFVDGFAIAEALRIEAPAAYRLLCETPVEFRNKDRHSDYRCTAPVIALDSSGEVREIRLANFLRAPFQMDAQRMPDYYLAYRRFIQMTREPRFCFTRRLEAGQLWCFDNRRVLHARDAFDPASGDRHFQGCYVDRDELLSRILVLQR
What is the function of this protein?
Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
What are the official names of this protein?
Gamma-butyrobetaine dioxygenase, Gamma-butyrobetaine hydroxylase, Gamma-BBH, Gamma-butyrobetaine,2-oxoglutarate dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-BBH/TMLD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMKL_PSEP1
Sequence: MSDRFELYLTCPKGLESLLAEEAKGLGLDEVREHTSAIRGAADMETAYRLCVWSRLANRVLLVLKRFSMKNADDLYDGVHAVDWADHLAADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDKLRNREGLRPSVEKIDPDVRVHLRLDRGEAILSLDLSGHSLHQRGYRLQQGAAPLKENLAAAVLIRAGWPRIAAEGGALADPMCGVGTFLVEAAMIAADIAPNLKRERWGFSAWLGHVPALWRKVHDEAQARAQAGLAKPPLWIRGYEADPRLIQPGRNNVERAGLGDWVKIYQGEVSTFEPRPDQNQKGLVISNPPYGERLGDEASLLYLYQNLGERLRQACMGWEAAVFTGAPQLGKRMGIRSHKQYAFWNGALPCKLLLFKVQPDQFVTGERREAQPEGTEARQQVPQASEPARLSEGAQMFANRLQKNLKQLGKWARREQIDCYRLYDADMPEYALAVDLYQDWVHVQEYAAPRSVDPDKAQARLLDALAAIPQALGISPQRVVLKRRERQSGTRQYERQATEGRFQEVNEGGVKLLVNLTDYLDTGLFLDHRPMRMRIQREAAGKRFLNLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYSERNRLEQSDVMAWLEGNRDSYDLIFIDPPTFSNSKRMEGVFDVQRDHVQLLDLAMARLAPGGVLYFSNNFRKFQLDEHLMARYVVEEISAQTLDPDFARNNRIHRAWRLQLR
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAP1B_XENLA
Sequence: MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSTCHLL
What is the function of this protein?
Probable GTP-binding protein that possesses GTPase activity.  May play a role in endothelial cell polarity and endothelial barrier function (By similarity).
What are the official names of this protein?
Ras-related protein Rap-1b.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol.
Protein: SPT5H_CHICK
Sequence: MSDSDDSNFSEEESEHSSEAEEAEEAEAEEERASAAGSEKEEVEEEEEEEYDEEEEEEDDDRPAKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAIALMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKQAIEGVGNLRMGYWNQQMVPIKEMTDVLKVVKEVTNLKPKSWVRLKRGIYKDDIAQVDYVEPSQNQISLKMIPRIDFDRIKARMSLKDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKEREHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQNNIHVKDIVKVIDGPHSGREGEIRHLFRGFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGSFAPMSPRISSPMHPSGAGQRGGFGGGGMSRGRGRRDNDLIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYGSQTPMYGSGSRTPMYGSQTPLHDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRADEDFEYGFDDEPTPSPQGYGGTPNPQTPGYPDPSSPQVTQPYNPQTPGTPAMYNTDQFSPYAVPSPQGSYQPSPSPQSYHQVAPSPVGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQSSSDWVTTDIQVKVRDTYLDSQAVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPVTPTKSNKVKVILGEDREATGILLSIDGEDGIVRMDLDEQLKILNLRFLGKLLEA
What is the function of this protein?
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II.  DSIF acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter.  Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (By similarity).
What are the official names of this protein?
Transcription elongation factor SPT5, DRB sensitivity-inducing factor large subunit, DSIF large subunit.
What is the protein family that this protein belongs to?
Belongs to the SPT5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: F241A_MOUSE
Sequence: MCSARKLLRGGAGSAGGECDEDGAAPAGRVEEPEHGASPRRRRPQDEGEQDIEEPQNHSGEPIGDDYKKMGTLFGELNKNLLNMGFTRMYFGERIVEPVVVLFFWLMLWFLGLQALGLVAVLCLVIIYVQQ
What are the official names of this protein?
Uncharacterized protein FAM241A.
What is the protein family that this protein belongs to?
Belongs to the FAM241 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LEPA_BACP2
Sequence: MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTAAITQREMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIMHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNNLEILPIINKIDLPSAEPERVRGEIEDVIGLDASEAVLTSAKAGIGIEDILEQIVEKVPAPAGDPEAPLQALIFDSLYDAYRGVIAYIRIVEGTVKPGQKIKMMATGKEFEVLEVGVFTPKAMPTDELTVGDVGYLTAAIKNVGDTRVGDTITSAVNPAQEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSLQYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFKIDLITTAPSVIYDVYMTDGEKIVVDNPSNLPDPQKIERIEEPYVKATMMVPNDYVGSVMELCQGKRGHFIDMQYLDANRVSIVYEIPLAEIVYEFFDQLKSNTKGYASFDYELIGYRPSTLVKMDIMLNGEKIDALSFIVHRDYAYERGKIIVDKLKELIPRQHFEVPIQAAIGQKIVARSTIKAMRKNVLAKCYGGDISRKRKLLEKQKEGKKRMKQVGSVEVPQEAFMAVLKMDDSTPKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y2385_MARSD
Sequence: MPSFDIVSQIDAQEVDNAVNNVLKEIDTRYDFRGVNTEIDLNKKTNTISLVTGDEMKIKAVKDMMITHFTRRKVDPRSLDFGKVEPTSSAQLKQEIKLKEGIDKDTAKKIVKLIKASKLKVQAAIQDDQVRVTGKKLDDLQSVIALVRDSDLDMPFQYVNMKK
What are the official names of this protein?
UPF0234 protein Desal_2385.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: GET1_CRYNB
Sequence: MINLALVIFLCTLLNQIVSWVGKSVLQEIAFTAYSWVFLSGTAAKQRKLRKQVLEDKAELGRTSSQDEFAKWAKLRRKLDKGLADLEKTNNTLSSSRSSFSKKFSTLLWLMTTGAQFLLSWWFRKQPIFWLPEGWVPYPVAWLLSFPSAPIGSVSSGAWGAICRRVLSTLQEIIQSVLAPSPAATGPVPTGPSSAKNDQPEAKIEALALEHEKLD
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
What are the official names of this protein?
Protein GET1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: COBS_BREBN
Sequence: MNAFLHAISFFTRIPVPWLRPSEEAWRKSVNWYPAVGLVIGLLLWGVHQAGLVLFSPWIAAILTLIAWVYVTGGLHMDGWMDLADGLGSSRPREQILAIMKDSRVGAMGVLAAIMLLLIKAGAVAELAHPGWGSFLIVAPVAARTHVLLSIKLWPYLSADKGIGKGISSGLSVSSIIVSYIIVFAAGWYLGGLQVMTAIFLSLLFALWFSRSVAKKLGGLNGDCYGAVIESSEAVVLLVLVGSWWL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRF_OCEIH
Sequence: MTMFVALDFPDWKQTEAFLYKNELQGVPVKVGMELFYKEGPSVIEKLKRNNHSIFLDLKLHDIPNTVHRAMKNIASLGVDLVTIHTLGGSEMIAQAKRGLEHSQTKLIAVTLLTSVDEEVVQHQLRLPGNIPANVAHLASLAKANGADGVVSSVHEVASIKKTCDTSFLTLTPGIRFDSSDVHDQKRVATPEMANQVGSDFIVVGRAITQSDHPYTAYMEAKKRWEEASDE
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.