PharMolix/UniProtQA huggingface dataset:
Protein: TRA2_CAEBR
Sequence: MKLAFNKLLVASVVFTVLSFGLLLASLFTTTATTPSEWTILLPEFRFPVNKKQTTEQFLVEKIVHEHEEGEDVRSALYLTHHGYFMNAIANMKVTYRQKSYTVNDVCFKPHSAIFENVPAPENIDKLPAYFQRLLLEMQRLSPCLIVTPLNCFYDSYHIHSEISNWNASTDYLNRRLRNSYLEAIEEKDSRPYVKSTYGPELIKEWARHMFAIPSKPLSNFSKSDLYSRVKTWLSSIAARKKICADPMRSCDETLDAENYFNVCTVMQQINDYDERRKQRLKFQLEYGDEEFTTRLDCVEDREKFIEWMQERNLRDMLKLFASSVEIPDHKEIPNQVCDGIYHDLDTSSGLELFRGARSFSNNTSAYDTINVELGFMTPENLLTTMRHSDFVNGFESIWTIERARELLNEFRLALKVEVTKFSESRSSRRVKVTTRIVNQIEEEGSDEEMEYHMIYFILGACALMVALFAAFAFSEAFLTSLSMFLLRGFITGLLFIFLCKSGGLILIDSNFLCYITMHLAFNLVMTARVTFICYRIGGCVQSEKDFVKSNFSSLGSVPVDSLKEDSCKRHVQYVLAKYTKFQVAQDAYSEEPFEKLPKYWFLIAIVLVPVIGVYWFFIDSDVQKICIVLLPAFLIAAFEEMRVKNQLLRERRIKKAIQRLQKEENTRIMSRGEIDNLLSGNAELSGEKSHYESKQGVLHHGSAGGLFELSRSTYDVSLIMAYPNQMIRNLRLCALGAYFRLFKMKYCAVVVSSVAALLILLSIGLLFIPVQRSSVPKELQQDELSIDFAIPNVSSSSWESINEYLEEFNSEIDSITNLQTITNGRRVLINSTSKINNFLKWVDDEPISWYLTAPLTRPYRKTHLPNPFRFQFRYGFDSIQKSTIIDVVERIDTLLTKYTETLSFPKAIGFLYEHYHQKAVVWNSFAYHEIFAAAVLAGFFSIIVVFFSIGPVVLPTLAFAFFVVGNRLEIAAIVSLFSLEYHQCYTNVAVFVGFLAAWTPFCDLARFRGRLLYKDQTRRTPELATQRRIRVPHVAAVDTVQIFAIFLTATILLIVITAIIPQFRAFFIPTVILLITLLLAVFNSLAVSLAAYQMFEHEVRHCYHDQLQSLTTTGKVCDMTRKKLLPREEDLSIPMEEFSIRPTENTKHYAPRPIDNSDPPEQAADEEVVNQDPSMEAARRQYVEFTHRTTGMPIELINQFVDNFPVFNVPANFLPNYFALGGAPLDANNGVLLRQPGIAPPPRPNREEDEEERFGLGGGEDDDSYPSSGDDIGDPAKEQQEVTDDVATRYKEEEVRKKVQPAVPNYDDPNVPGPSNPVPRQVEQVSREAPEDSPNREPRILVYQRPPRLHEIPQISHGRNPLHDPPSMEEYVQKYDDPNQPPSRRADQYPPSFTPAMVGYCEDVYWKYNERNLPDNVPMPPRPRDWDQRRLVELPPPEDFDEVPPPGRSAIPIPPGAIRLRERRREQHLREQEARRNRPESPDDTPGL
What is the function of this protein?
Plays a major role in controlling sexual cell fates (PubMed:8889523, PubMed:11250902, PubMed:24098152).  Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development (By similarity).  In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1 (By similarity).  Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis (PubMed:12477393).  Also required for feminizing tra-3 activity (By similarity).
What are the official names of this protein?
Sex-determining transformer protein 2, Cbr-Tra-2A, Cbr-tra-2.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LEUC_ECOLI
Sequence: MAKTLYEKLFDAHVVYEAENETPLLYIDRHLVHEVTSPQAFDGLRAHGRPVRQPGKTFATMDHNVSTQTKDINACGEMARIQMQELIKNCKEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGKDFDDAVAYWKTLQTDEGATFDTVVTLQAEEISPQVTWGTNPGQVISVNDNIPDPASFADPVERASAEKALAYMGLKPGIPLTEVAIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRNIK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: PGK_MYCLB
Sequence: MRIPNLKDLLEEGVSGRCVLVRCDLNVPLGDDGAITDLGRVTASVPTLKALLEAGAKIVVAAHLGRPKNGPDPKLSLEPVAAALGEQLGQNVQLVCSTDRSPVGGDALACVERLTDGDLLLLQNIRFDPRETSKVDDERLALAKQLVELVGSAGAFVSDGFGVVHRRQASVYDVATLLPHYAGILVADEIRILEQLTSSAKRPYAVVLGGSKVSDKLGVIESLATKADSIVLGGGMCFTFLAAQGFSVGKSLLETEMIETCRSLLDTYADVLRLPMDIVVTEKFVADSPPQTVAADAIPDGLMGLDIGPESVKRFATLLSNASTIFWNGPMGVFEFPAYAAGTRGVAEAIVAVTGKGAFSVVGGGDSAAAMRALSLPEGSVSHLSTGGGASLEYLEGKTLPGIEVLGREQPRGGDS
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_PARMW
Sequence: MISSNDFRTGTTIEIDGAVWRVVEFLHVKPGKGSAFVRSKLKAVKTGNVVEKTFRAGEMLPQALLEKASLQHTYMEGEDYVFMDMSTYEETRLSADQIGESRKYLKEGMEVNVVSWNGSPLEVELPNSVVLEITETDPGVKGDTATGGTKPAILETGAQVMVPLFLSIGEKIKVDTRSDSYLGRENG
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_STRA5
Sequence: MKRHFETTRRIVIKVGTSSLVQTSGKINLSKIDHLAFVISSLMNRGMEVILVSSGAMGFGLDILKMDKRPQEISQQQAVSSVGQVAMMSLYSQIFSHYQTHVSQILLTRDVVVFPESLQNVTNSFESLLSMGILPIVNENDAVSVDEMDHKTKFGDNDRLSAVVAKITKADLLIMLSDIDGLFDKNPNIYDDAVLRSHVSEITDDIIKSAGGAGSKFGTGGMLSKIKSAQMVFDNNGQMILMNGANPRDILKVLDGHNIGTYFAQGK
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_STRP6
Sequence: MLKPSIDTLLDKVPSKYSLVILQAKRAHELEAGATPTQEFKSVKSTLQALEEIESGNVVIHPDPSAKREAVRAKIEAERLAKEEEERKIKEQIAKEKEEEGEKI
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: CYB_CAPSU
Sequence: MTNIRKTHPLMKIVNNAFIDLPTPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYTFLETWNIGVILLLTTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIMALAMVHLLFLHETGSNNPTGIPSDTDKIPFHPYYTIKDILGAMLLILTLMLLVLFTPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILALVPFLHTSKQRSMMFRPISQCLFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFLIILVLMPVASTIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PROB_TREPS
Sequence: MIRALFAAAKKIVIKIGSNTLAQADGTPDEEFLAECARACAALMRDGKQIVVVSSGAQVAGISALHCLSSPPQGAGLERHESRGVIPGDGASCKQALCAVGQAELISRWRSAFAAHQQCVGQFLCTKEDFTDSDRAAQVRYTLSFLLERRVVPILNENDALCCSDVPSVPADRRVSLSPQKRIGDNDSLSAFVALLWQADLLLLLSDIDGVYDKDPKAHTDAQHVPLVTDVSALVGKTSMGSSNVFGTGGIATKLDAARLVTRAGIPLVLANGRHLDPILSLMRGDARGTLFVPVS
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHF1_SCHPO
Sequence: MSSRRNDYHYDGNDHQYRSPLKSNVDQNSFYESSYRSRQSYHQRTKTPRSSYDSPSSSTNSKEHNSPYHYRVPSNNSTRASFGAASTDTNVELPKINLPDSSLSSKLQSCKSACENSSQSLLNVEQQYAQQVHFWEKIRTDIYREGLRSDAAVKSLNDFVNNVSF
What is the function of this protein?
Component of the histone H2B ubiquitin ligase complex (HULC) which plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1.  H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
What are the official names of this protein?
Small histone ubiquitination factor 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: YIDD_STAA9
Sequence: MKKIFLAMIHFYQRFISPLTPPTCRFYPTCSEYTREAIQYHGAFKGLYLGIRRILKCHPLHKGGFDPVPLKKDKSASKHSHKHNH
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: IL10_RABIT
Sequence: MLSSALLCCLVFLGGTGASRGQDTPAENSCIHFPGGLPHMLRELRAAFGRVKTFFQSKDQLNSMLLTESLLEDLKGYLGCQALSEMIQFYLKDVMPQAENHSPAIREHVNSLGENLKTLRLRLRQCHRFLPCENKSKAVEQVKSAFSKLQEEGVYKAMSEFDIFINYIETYMTMKIKS
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NEK4_HUMAN
Sequence: MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMNF
What is the function of this protein?
Protein kinase that seems to act exclusively upon threonine residues (By similarity).  Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence.  Required for normal cell cycle arrest in response to double-stranded DNA damage.
What are the official names of this protein?
Serine/threonine-protein kinase Nek4, Never in mitosis A-related kinase 4, NimA-related protein kinase 4, Serine/threonine-protein kinase 2, Serine/threonine-protein kinase NRK2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm.
Protein: RECA_ECO5E
Sequence: MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLSNPNSTPDFSVDDSEGVAETNEDF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN692_BOVIN
Sequence: MAASPADASRRRREKRRQLDARRSKCRIRLGGHMEQWCLLKEQLGFSLHSQLAKFLLDRYTSSGCVLCAGPEPVAPKGLQYLVLLSHAHSRECSLVPGLRGPGGQDGGLVWECSAGHTFSWGPSSGPKSPEEPNLTPLPSTDERSWCPEAKSGQEPAGLESNCDERAQEARMPRGAGPPPETFPSLGEDGEEEEEDEEEMLSDASPWTYSSSPDDEPDVPKPPPSPVTHALKDGEIAPAPAAVPAPLASPSSSASSLGSGAPGPVEVRIQPELRGTPQADQQTEPLASPGSQAQSALASAWDEDTAQIGPKRIRKAAKRELLPCDFPGCGRIFSNRQYLNHHKKYQHIHQKSFSCPEPACGKSFNFKKHLKEHVKLHSDTRDYICEFCARSFRTSSNLVIHRRIHTGEKPLQCEICGFTCRQKASLNWHRRKHAETVAALRFPCEFCGKRFEKPDSVAAHRSKSHPALLLAPQELSGPVESCSSILASASLGASEGSRSTLAPQAPILLP
What is the function of this protein?
May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway.
What are the official names of this protein?
Zinc finger protein 692, AICAR responsive element binding protein.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACP_MANSM
Sequence: MSIEERVKKIIVDQLGVKEEEVKSEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYVQNNQ
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_HERA2
Sequence: MRMSSGFGRTLREAPSEAELAAHQLILRAGLARQLLAGGMALLPLGMRVFRRIEAIMHAELAAIGAGEFRTPVVHAASLWEQTGRYAQYGEAMLRFNNRNQQALLFAPTHEEAVAELARREVDSYRQLPSLLYQIHTKYRDELRVRGGLLRLREFTMLDAYSLDTDWAGLDMVYDRVALAFETIFERCGVRFTAVEADGGEMGGREPREYMAFSSSGEDSLVVCPLCSYAANSEVAVRGQAAANDDVVPAMSEIATPACTTIAELATFLQVSEAQTAKAVFFNSAEKGLIFVVVRGDREVNEIKLRAAAGVSALEPATLEQISAVGAVAGYASPVGLSNVTVIADHSVVGVGGLVAGANRTGYHLQNVVYGRDWQATVVADIANVEEGDACPVCGAALSLERGIEIGHIFKLGTRYTEALGATYLDPQGQAQPIVMGSYGIGLERLLQVIIEQHHDEKGIVWPASVAPFDLHLVQLGASATVSEAANQLYQQLSEAGLSVLYDDRNESAGVKFNDADLLGMPLRLTVGERGLKQNVVELRQRATGVVETIALDQVVKSIKNIEHRA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_DHVI1
Sequence: MVDSTIRLVATIFLISLTQQIEVCNKAQQQGPYTLVDYQEKPLNISRIQIKVVKTSVATKGLNFHIGYRAVWRGYCYNGGSLDKNTGCYNDLIPKSPTESELRTWSKSQKCCTGPDAVDAWGSDARICWAEWKMELCHTAKELKKYSNNNHFAYHTCNLSWRCGLKSTHIEVRLQASGGLVSMVAVMPNGTLIPIEGTRPTYWTEDSFAYLYDPAGTEKKTESTFLWCFKEHIRPTTELSGAVYDTHYLGGTYDKNPQFNYYCRDNGYYFELPANRLVCLPTSCYKREGAIVNTMHPNTWKVSEKLHSASQFDVNNVVHSLVYETEGLRLALSQLDHRFATLSRLFNRLTQSLAKIDDRLLGTLLGQDVSSKFISPTKFMLSPCLSTPEGDSNCHNHSIYRDGRWVHNSDPTQCFSLSKSQPVDLYSFKELWLPQLLDVNVKGVVADEEGWSFVAQSKQALIDTMTYTKNGGKGTSLEDVLGYPSGWINGKLQGLLLNGAISWVVVIGVVLVGVCLMRRVF
What is the function of this protein?
Attaches the virus to host cellular receptor and later induces fusion of virion with host membrane.
What are the official names of this protein?
Envelope glycoprotein.
What are the subcellular locations of this protein?
Virion membrane.
Protein: SYP_PYRCJ
Sequence: MRLVREARPHGREKLRSNLMEWFHWLLREAEIYDVRYPVKGAYVWRPYGMKIRRNVEALIRRLHDETGHEEVLFPVFIPYEFFGKESEHIRGFEKEVFWVSKGGEGGERLVLRPTSETAIMPMVKLWVQDYKDLPLRLYQIVSVFRAETKMTHPMIRLREISMFKEAHTVHVDREDAERQVREAVEIYKRIFDEMCLAYMINRRPDWDKFAGAVYTIAFDTVLPDGRALQIGTVHYLGTKFTEVFEVTYLAPDGSRRLAHTTSYGISERSIAAMLITHGDDAGTVIPPKLAPIQVVVVPIFYGEEEKGVVMPAAEQAAKALREAGFRVHVDGRDDKTPGWKFYYWELRGVPLRVEVGKRDVEGRQVVVARRDTLAKYAVAVDELVDAVKALLSEVEANLRRRAVEELRGRIVRVETVEAARAAIREGKVVELPWSGDNDCGLKLQELVGADALGVPMDSEASVGGFDLRDPACGKRAEVWLRLAERY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAE2_SCHPO
Sequence: MDIVKQRYHELFDLRVRGPRMKMADRLEHFTWAWFASAMGTGGIGMVTSLYHFRFYGLNTLGKIIFIFQLSILTLYICCITFRFIRYPGTLSKTWKNPSEVLFMPTALLAIATSISNLYPYAFPYTGEWMVWLIRILYWIFVAVACIFVISLFYSLFHAHPFRINTIIPALVLPIFPCMICGVIASAIVESQPARQAKNMVVAGIAFQGLGFWIYIIVYAVNMCRFFTVGLQPAADRPGMFILVSPPSFTGLTLLDLAFGAKAKRPYIFVGDNSSEYLEFVATFMALFMIGLGIFNFCLAFVSVVAGFCTRQRIKFKVSWFAMIFANVGLVMDVQELGRAIDSKAVCIVGQVCGVTITIVWIILILLTLRAVYVQELLYPGKDEDIDTILPNVLEYYRHLEEEEKDEAERSKRKAEESDGKTTRELTSGGL
What are the official names of this protein?
Putative malic acid transport protein, Malate permease.
What is the protein family that this protein belongs to?
Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ZC3C1_XENTR
Sequence: MATSCEDVSPVKSPAVTPLKIRELINEGIVTGERSSIGRKETAVVPEENNGFEDPLSNSSYESTSKDAFFGRVESFSSLKWAGKPSELCPLICAKYGWSNIECDMLKCSSCNAYLCASLQPVLDFSKYKQRCVELQEALRKAHEKFCFWPDSPCPDYFWALMVTEPSSVLSDFVGRFDNLCHLEIQLPSIKHEDLKNMDITEETVSHLLRLIEDELKSKDGREDNSRLASDSLQVHISACILALCGWSTSYTSGSLCIINCPRCMRKVGLWAFQQLEAVELDNSLSAPNTPVSPAEGHERSPFGIMSPNRRVTRSRDAEQSPALAYGRTRSSDLLSPADSEAVRSRPVTRSMGQGESSGLSNELHSSPLRRSKRPRLCSSSSSDTSPRGCFDPLSQHRSWCPWVNVCQASETSTLGSEIQEEASRKEYGWKEVLNVLLAEENSRTLSDPDTSSVPEKSHKVFRIFRQWQMAASASENP
What is the function of this protein?
Probable component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1).
What are the official names of this protein?
Zinc finger C3HC-type protein 1-like, NIPA-like protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: PP12_YEAST
Sequence: MDSQPVDVDNIIDRLLEVRGSKPGQQVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQKSLPRQAGGRKKK
What is the function of this protein?
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.  Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation.
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1-2.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DHE2_STAAS
Sequence: MTENNNLVTSTQGIIKEALHKLGFDEGMYDLIKEPLRMLQVRIPVRMDDGTVKTFTGYRAQHNDAVGPTKGGVRFHPDVDEEEVKALSMWMTLKCGIVNLPYGGGKGGIVCDPRQMSIHEVERLSRGYVRAISQFVGPNKDIPAPDVFTNSQIMAWMMDEYSALDKFNSPGFITGKPIVLGGSHGRDRSTALGVVIAIEQAAKRRNMQIEGAKVVIQGFGNAGSFLAKFLYDLGAKIVGISDAYGALHDPNGLDIDYLLDRRDSFGTVTNLFEETISNKELFELDCDILVPAAISNQITEDNAHDIKASIVVEAANGPTTPEATRILTERGILLVPDVLASAGGVTVSYFEWVQNNQGYYWSEEEVNEKLREKLEAAFDTIYELSQNRKIDMRLAAYIIGIKRTAEAARYRGWA
What are the official names of this protein?
NAD-specific glutamate dehydrogenase, NAD-GDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: RWDD3_MOUSE
Sequence: MAEEVRQELSALAAIFCGPNEWEMLSCSETDGAVFRIHTTAEGLVGEDVPLELAFHLPVGYPLCLPGISVTSEHLTRAQCVTAKEKLLGEARKLVSEPMVHELVLWIQQNLRLVLSQPETVSSHEKCTLPESATGDDGPWMTLLRLDHMRARTKYVKAVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVLSETKVQTEHKRFLAFEVKEYSTLEELQKEFGAAGLGELFSECVLGLVK
What is the function of this protein?
Enhancer of SUMO conjugation.  Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1.  Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity.  Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia.  Has no effect on ubiquitination.
What are the official names of this protein?
RWD domain-containing protein 3, RWD domain-containing sumoylation enhancer, RSUME.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Colocalizes with UBC9/UBE2I in nuclear spots.
Protein: HTPG_SALTI
Sequence: MKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSNPDLYEGDGELRVRVSFDKDKRTLTIADNGVGMNRDEVIDHLGTIAKSGTKSFLESMGSDQAKDSQLIGQFGVGFYSAFIVADKVTVRTRAAGDKPENGVFWESAGEGEYTVADITKNDRGTEITLHLREGEDEFLDDWRVRSIISKYSDHIALPVEIEKREEKDGETVISWEKINKAQALWTRNKSEIKDDEYNEFYKHIAHDFTDPLTWSHNRVEGKQEYTSLLYIPSQAPWDLWNRDHKHGLKLYVQRVFIMDDAEQFMPNYLRFVRGLIDSNDLPLNVSREILQDSTVTRNLRSALTKRVLQMLEKLAKDDAEKYQTFWKQFGLVLKEGPAEDHANQEAIAKLLRFASTHTDSSAQTVSLEDYVSRMKEGQEKIYYITADSYAAAKNSPHLELLRKKGIEVLLLSDRIDEWMMNYLTEFDGKAFQSVAKADESIEKLADEVDENAKEAEKALEPFVERVKTLLGDRVKEVRLTHRLTDTPAIVTTDADEMSTQMAKLFAAAGQSVPEVKYIFELNPDHVLVKRTADTKDEAQFKEWVELLLDQALFAERGTLEDPNQFIRRMNQLLVS
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.