PharMolix/UniProtQA huggingface dataset:
Protein: YQIC_CAEEL
Sequence: MNAFSIILLLLSVLLINAQFQPRTSNRGTIFRPMTRNSGIVGRRGGPVAPAPFRNNVQKPGTRPPGFKPPSGVAKKLNSAVDFRALARVLLKQ
What are the official names of this protein?
Uncharacterized protein C45G9.12.
Protein: PAN2_CANGA
Sequence: MNNWQHSFNNARPLDEHLHKPYLQYDGIEKHLTKFIFDDHANLVWTGDTYGCVSSYDVNFQPYVRQRAHIGGSPVKDLMSHSSGVLSLSSDSLHLQDRRGTTLLNLTNIDIAAFNDLQTMCYMSADQTSKVYCAGTDIGTGLSLIDLQRGTLETNIPYFSKVNFIKSSKKLAAIGKLSGSIDLFDPGSNQVIKSFISHSSCITSMDIQDYTLVTTGQSNGFYNTFADPFVNVYDLRTMRQLPPISFSKSTSMGTVGADFVQLHPVLPTIVMIASSSGAFDFVDMANPSLRTQFANPGNGIKCIRLSSNGDHLGVLESNDMFSTWKRPNSSVNFTNMPELLTYPSYPNDGPLANISIDDYNYPLSTVGMPYYQEKLLSTWSTVIFRSPGTVPRDIDKILTDLKNSKKSKKLVADGVNFYPYSVAKYGHKDALQPYISLRDKRYQRSTGSVPDDVLITKSVDGELPPAFKNLPLVVTKYATDSFDFESVNKTPYCGLDNDVDNPFTNALIQLYRFIPEISNFLISTLKHEHFESPLLTDMAYLFDMMRNTIDGICRTTNYQMSLNDVLEKNNLSLHTISESNMLQKINSLSLNDDGGKKQLSIQELNDFLLSELCEEEVKFIDQNFVLQHCYCCEFAVKTKGCMTYGQTSGSLYKPSITIGPNACTQKNGKVSYPHSILGYIEHGLKNSIVLNKKCEQCGIKENLEEDISIQELPPILSLSLEFDDNAMKLAKTTKNWLPKEFYASIMKNKPLVRGSVNDIRTNTMIYKYELHGYIARISDPDRGDHYVTFSRIYNEESKMFRWYLFNDYLVTEVDESIVYDLGKHWLKPEVVIYGDAEELRKPFNYLKDVEIDDSILYKDYFSAAIRESIQKEYELLTRNEAPRPGSLIAIDAEFVTLKNEKYDIDCRGAKTVVQSKVSALARISVVRGNEEQFGVPFIDDYIIIEKNIDDYLTKFSGILPGDLDPKTSNKHLVPRNVAYRKIWLLMQLGCTFIGHGLQNDFKHINISVPKEQIRDTAVYFLQGKRYLSLRYLAYVLLDINVQEGNHDSIEDAYTALVLYKKYLELKSNGMMDQVLNKLYEEGRTTNYKVPLKL
What is the function of this protein?
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex catalytic subunit PAN2, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. PAN2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1102L_ASFB7
Sequence: MRFFSYLGLLLAGLTSLQGFSTDNLLEEELRYWCQYVKNCRFCWTCQDGLCKNKVLKDMSSVQEHSYPMEHCMIHRQCKYIRDGPIFQVECTMQTSDATHLINA
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 110-2L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 110 family.
Protein: Y1439_BORBR
Sequence: MMKGQLAGLMRQAQQMQENMKKAQDALAEIQVEGAAGGGLVKVTMTCRHDVKRVAIDPSLLGEDKDMLEDLVAAAFNDALRKAEATSQEKMASVTAGMPLPPGMKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein BB1439.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CLPX_GEODF
Sequence: MSRRDDRSDNLICSFCGKSQEEVKKLIAGPTVYICDECIELCNDIIAEESKLEEATGPDVKKLPKPLEIKDVLDEYVIGQKQAKKVLAVAVYNHYKRIEAMTKPGEVEMQKSNILLLGPTGSGKTLLAQTLARILKVPFAMADATNLTEAGYVGEDVENIILNLLQAADYDVERAQKGIIYIDEIDKIARKSDSPSITRDVSGEGVQQALLKIIEGTVASVPPKGGRKHPQQEFLKVDTTNILFICGGAFAGLENIIQQRIGVKTLGFGADVKKKIEKKAGELLIGVTPEDLLKFGFIPEFVGRLPVLASLTELDEEAMVQILKEPKNALVKQYQKLFDMEHVKLKFTDGSLVAIAREALKRKTGARGLRSILENAMLDIMYEIPSQTMVKEVVISEDVIYNKEKPIIVYESVAESA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: AMPA_RHIME
Sequence: MPMKFEFSFSKSHRPAGGAAVLLQVAGAKEAAGAAVVDPEGVLAKAAKIGKFTGKALSTLDVIAPHGSPADRIVLLGLGDAGGVGDHDWLKAGGAAAAKLRSAEKITVFLDAPGLEVTGKAAADFALGMEMNAYGFESYKTRKSDDEPKAAQKPVKVTIVTGTVIAAKKAFMTAQAVGEGVFLARDLVNEPANVLGPVEFAARAKELERLGVDVEILTEREMKKLGMGALLGVAQGSSRPPRLVVMQWKGGKAKEKPVAFIGKGVVFDTGGISIKPASGMEEMKGDMGGAAAVTGLMHVLAARKAAVNAIGIIGLVENMPDGSAQRPGDIVTSMSGQTIEVINTDAEGRLVLGDALWYCNDRFKPQLMIDLATLTGAIMVALSNHYAGLFSNDDRLAEQLLAAGLATQERLWRMPLGKEYDKMIDSKFADMKNTGGRHGGSVTAAQFLKRFVKDTPWAHLDIAGTAMGSPTDEINQSWGSGFGVRLLDQLVRANYES
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_PROMM
Sequence: MRLLLLNGPNLNLLGQREPGFYGAMTLKAIEADLLAQAEAEAVQLECFQSNFEGALVDQIHQAIGQVQGILINAGAYTHTSIALRDALLGAAIPYVELHLSNTHAREGFRHHSYLADRAVGVVSGFGALSYRLALEGLLAHLRQPQQVL
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: MYO5B_HUMAN
Sequence: MSVGELYSQCTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQRNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQSPGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKAQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQERNDPQQLLLDAKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV
What is the function of this protein?
May be involved in vesicular trafficking via its association with the CART complex.  The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.  Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane.  Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells.  Together with RAB11A and RAB8A participates in epithelial cell polarization.  Together with RAB25 regulates transcytosis.  Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes (PubMed:34816459).
What are the official names of this protein?
Unconventional myosin-Vb.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASNA_STRP3
Sequence: MKKSFIHQQEEISFVKNTFTQYLIAKLDVVEVQGPILSRVGDGMQDNLSGTENPVSVNVLKIPNATFEVVHSLAKWKRHTLARFGFNEGEGLVVNMKALRPDEDSLDQTHSVYVDQWDWEKVIPDGKRNLAYLKETVETIYKVIRLTELAVEARYDIEAVLPKKITFIHTEELVAKYPDLTPKERENAITKEFGAVFLIGIGGVLPDGKPHDGRAPDYDDWTTETENGYHGLNGDILVWNDQLGSAFELSSMGIRVDEEALKRQVEMTGDQDRLAFDWHKSLLNGLFPLTIGGGIGQSRMVMFLLRKKHIGEVQTSVWPQEVRDSYDNIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1235_HALOH
Sequence: MAGHSKWANIKHKKAKEDRKRGKLFSKLSKMITVAAREGGGDPEMNPDLRLAIQKAKDNNMPNDNIERAIKRGTGELEGVKYEKFVYEGYGPGGVALYLELMSDNRNRTAAEIRHVLSKNGGNLGESGCVSWMFKRRGQLIVDLNESDFDEDELMLEALEAGAEDVVTEDNLLTIYTDPSDFEEVRKQLEEQGIKFSSADIAMVPENNVNVDDKSTAKKVLKLMDALEDHDDVQEVYSNFDIPDEIMEEITEE
What are the official names of this protein?
Probable transcriptional regulatory protein Hore_12350.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTP_KLEP3
Sequence: MIKRVLTALAATLLPLGAHAADAITGAVQRQPTNWQAIVMFLIFVALTLYITYWASKRVRSRSDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVVLVGVLMVLYVLFGGMLATTWVQIIKAVLLLCGASFMAFMVMKHVGFSFNNLFTEAMAVHPKGAAIMSPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAFKDAAGQLIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFRKGATERQELKVSKITVLILGVVAILLGILFENQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMVGGWLGLLTAVILMILGPTIWVQILGHEKALFPYEYPALFSIAIAFIGIWVFSATDNSPEGMREREQFRAQFIRSQTGIGIERGQAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AKRC8_ARATH
Sequence: MAAPIRFFELNTGAKLPCVGLGTYAMVATAIEQAIKIGYRHIDCASIYGNEKEIGGVLKKLIGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLKKESLMPTPEMLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARVTPAVNQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLKVLQNPIVTEVAEKLGKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPEDLFTKFSNIPQEKFCRATEFAHETHGFYKTIEELWDGEI
What is the function of this protein?
Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids.  May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress.
What are the official names of this protein?
Aldo-keto reductase family 4 member C8.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: RN081_SACS2
Sequence: MVKLVATLGTSPGGVIESFLYLVKKGENIDEVRVVTTSNAEVKKAWRIVRLMFVCCIQEKFPKVEISEHPLDIEDIYSEDDLRKVREFVEKQLGEGDYLDITGGRKSMSVAAALAAKNKGVKIITSIIPQDDYNKISKKVRELKEIPEIKNRGECRQEMKETYCSLIVQDARSIEFEI
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable).  A nuclease that degrades cyclic oligoadenylates (cOA), second messengers that induce an antiviral state important for defense against invading nucleic acids.  Destruction of cOA deactivates the Csx1 ribonuclease, preventing uncontrolled degradation of cellular RNA.  Degrades cA4 (a tetraadenylate ring) into a linear diadenylate product with 5'-OH and 2',3'-cyclic phosphate termini.  Is 10-fold more active than SSO1393, suggesting this is the major cA4 degradation enzyme.  Is highly specific for cA4; it has very poor activity on cA6 and no discernible activity against a number of cyclic dinucletides.  There may be 2 active sites per homodimer (PubMed:30232454).
What are the official names of this protein?
CRISPR system ring nuclease SSO2081.
What is the protein family that this protein belongs to?
Belongs to the cOA ring nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPIF_BOMMO
Sequence: MASKNLFVLFFIFALFAANIAALQCPKNSEVRNSPCPRTCNDPYGQNSCITVIRETCHCKGELVFDSDSICVPISQC
What is the function of this protein?
Highly specific for fungal protease and subtilisin.
What are the official names of this protein?
Fungal protease inhibitor F, FPI-F.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I40 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRBJ_ECOLI
Sequence: MPPVLWRGWIPFCRCTEEKKVRNKQVVLLIAGISGIVTGIIVSLNIPFIRQGLFYPASPVEIVVSLSLTFSVSVVFFVGAIVGWISVSEIYYSRMTGLNESSEISEGTYNERK
What are the official names of this protein?
Protein TrbJ.
Protein: ERO1A_XENTR
Sequence: MVSGCCRLDMSSYVSVLVLCSLLLWGSNSQQEQSSAAQRCFCQVTGYLDDCTCDVETIDHFNNYGLFPKLQQLVASDYFRYYKANLKKPCPFWEDNSHCGVKDCAVKPCPTDEVPGLKPPGFKYTEEANRAHEEIDDCEKEKRLSAVDESLSVEAQEAMLKWNRHDDSADNFCELDDEESPDAEYVDLLKNPERYTGYKGADTWRIWNSIYEENCFKPKAVQRPLNPLTSTRGENEGKVFYNWLDGLCVEKRAFYRLISGLHASINIHLCANYLLKDTWMDKIWGHNTAEFQKRFDATLTQGEGPKRLKNLYFIYLIELRAISKVLPFFERSSFLLYTGNETKDTETKKLLLDVLLDARDFPLHFDENSLFSGDKKEAAKLKEDFRQHFRNISKIMDCVGCFKCRLWGKLQTQGLGTALKILFSERQIENLSESNQPSEFHLTRQEIVALFNAFARISTSVKELENFRTLLEKV
What is the function of this protein?
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum.  Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation.  Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell.  Required for the folding of immunoglobulins (By similarity).
What are the official names of this protein?
ERO1-like protein alpha, ERO1-L, ERO1-L-alpha, Endoplasmic reticulum oxidoreductase alpha, Endoplasmic reticulum oxidoreductin-1-like protein, Oxidoreductin-1-L-alpha.
What is the protein family that this protein belongs to?
Belongs to the EROs family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Protein: AROC_POLAQ
Sequence: MSGNTLGLLFTVTTFGESHGPAIGAVVDGCPPGMTLSEADIQADLDRRKPGTSRHVTQRKEEDKVEILSGVFEGKTTGAPIGLLIRNTDQRSQDYGDILQTFRPGHADYAYHYKYGFRDPRGGGRSSARLTAPVVAAAAIAKKWLKEHYGTEFYGYMGQLGEIEVPFQDKKHIAENPFFAANSEIIPQLEGYMDELRKAGDSCGARIEVRASNVPIGLGEPLFDKLDADIAHAMMGINAVKGVEIGAGFKSVSQRGSVHGDDLHPDGFASNNSGGTLGGISSGQELRVAIAIKPTSSIMTPKHSVDIKGQPITVQTKGRHDPCVGIRATPIAEAMLALVLMDHALRHRAQCGDVELAVPPIPASRPGSQLD
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: ISPE_HISS2
Sequence: MKNYQFSTALLSSQIQGKKLRFPCPAKINLFLYITSQRSDGYHELQTLFQFLNFGDWLSIEIRTDGKIILTPEIPHLKNEDNLIYRAAKLLQQKTGCTLGANLHLDKILPIGGGVGGGSSNAATALVALNYLWNTQLSLSTLAEIGLQLGADVPVFVYGKAAFAEGVGEKLTFCQPPQKWFLVLKPETSISTAIIFKDSNLPRNTSKRPLAELLTTKYENDCEKVVLNHYSEVEEALGWLLQYAPARLTGTGACVFAEFANEQAAQSAFLDKPEKYVGFVAQGTNISPLHQMIEYLSQQKQTLCLPNNTNSRG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: CD4_PANTR
Sequence: MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQTKILGNQGSFLTKGPSKLNDRVDSRRSLWDQGNFTLIIKNLKIEDSDTYICEVGDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAQRMSQIKRLLSEKKTCQCPHRFQKTCSPI
What is the function of this protein?
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.  In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex.  The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins.  Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs).  In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.  LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells.  In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway.  Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
What are the official names of this protein?
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts.
Protein: COTL1_MOUSE
Sequence: MATKIDKEACRAAYNLVRDDGSAVIWVTFRYDGATIVPGDQGADYQHFIQQCTDDVRLFAFVRFTTGDAMSKRSKFALITWIGEDVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKELEEDFIRSELKKAGGANYDAQSE
What is the function of this protein?
Binds to F-actin in a calcium-independent manner.  Has no direct effect on actin depolymerization.  Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity).
What are the official names of this protein?
Coactosin-like protein.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family. Coactosin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Protein: SRD1_YEAST
Sequence: MRYNNYDNSGSSFLTRVVKKSDMEKTLLLNREIDDWKSNDKKKAYKERGRVYASCSFIEVSFSQIRAVDVEKKIENAEQLRDLTRNIVKNKTSSLNEITPSKNRVTSACNSERRTTSQEANNLEGYHSCAQGTSRSASITKKYSKKTTSRPKREKRQTILPNGEIKECSKCKDTWTIQWRSGPDQNRELCSPCGLAYGKRLKKENEKKRQAADKRIDRNNP
What is the function of this protein?
Plays a direct or indirect role in pre-rRNA processing.
What are the official names of this protein?
Pre-rRNA-processing protein SRD1, Suppressor of rRNA-processing defect protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FLIK_BUCBP
Sequence: MFKIEYNVSRNSTSVRRGQFYLNAFQLKKECNNYVVSKNKNTFFRDMILKMQQTIKFKDNMKSINDDYIYLKNNYCHSYGIKNKNFCSFDYFIFSKLFIIKKTSSFSNLFVLPKISEFFVQKKCLFIGLNKSKYTNFSLGHNISSWFYDDKLCCLFSILNFLADTSLNSIFSLNRKRYYSIIYSLDRDKIFKFGKIYKLFDIFKKKFILSCDYKFWKKFVFKKMLVFLNNKTKCITFILNSKHLGSVFIYFKIINNKSIILDLVTCRNEIKKIFQSHIIYLKNVLKDCGIEVSSINVSSREEFLNAVRTNYDRKFDSKILNHYNTVISKTKSHALRFYELDKNDYQYNYNNINMYV
What is the function of this protein?
Controls the length of the flagellar hook.
What are the official names of this protein?
Flagellar hook-length control protein.
What is the protein family that this protein belongs to?
Belongs to the FliK family.
Protein: VATC_METAC
Sequence: MRLLERLWGKKPSRKSDKKKKGTSNYAYAVTRVRAMKSKLLPKETYPRLLNMGIDEITRFIQESEYKNDVDELAMKYSGGDLAEHALNRNLALTYDKLLRITSGELNYLIAAYLLRYDIWNVKTLLRGKLYNASVEDILESLISAGEFTYTFLSELAAKATYQEIIDALKETDYYPLLQEFDGNNLAYIENELDKMYYSSLFAAIGKPRSKDRKLFARFIKLEVDVKNLGTLFRLKKAGVEKSDEIMPLMIEGGLELKPEKLATLPYEQFIDELRKTQYWDAIATVTGLETASLTIVESRLIRYYLESATTYSHVSPISIVPIMEYIIHKNNEVNNLRIIFRGKEADLSDTLIKDQLVVI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit C, V-ATPase subunit C.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase V0D/AC39 subunit family.
Protein: ARAA_YERPN
Sequence: MDVFKQSEVWFVIGSQNLYGPKTLQQVMDNAHQVVNSLNNEAGLPVKLVLKPLVTTPDEITALCREANYDTACIGIMTWLHTFSPAKMWIGGLSILNKPLLQFHTQFNAQIPWKTMDMDFMNLNHTAHGGREFGFIGARMRQQHSVITGHWQDKEAHQRIGQWMRVAAAKQESQQLKVARFGDNMREVAVTEGDKVAAQIQFGYSVNAYGIGDLVAVVDAVSKGDIDTLVEEYEATYRFTDAVKLNGDKRENLLDAARIELGMTRFLEQGGFKAFTTNFENLYGLKQLPGLAVQRLMQQGYGFGGEGDWKTAALLRILKVMGTGLKGGTSFMEDYTYNFQPGNDLVVGSHMLEVCPSIAKEEKPLLDVQHLGIGGKADPARLIFSTPAGPALNASLIDMGNRFRLLVNVVDTVEQPHPLPKLPVARAIWQAQPSLATAAEAWIIAGGAHHTVFSQAVGVDELRLYAEMHGIEFLLIDNDTTLPAFKNEIRWNEVYYQLNR
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: RS17_EHRCJ
Sequence: MKEKKRKGMSNKKVLTGVVVATKCDKTIKVMVSRMVRHKTYKKIVKKRKNYVVHDEYNKCKCGDVVKIQEHIPISATKRWIVI
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: TRMD_STRR6
Sequence: MKIDILTLFPEMFSPLEHSIVGKAREKGLLDIQYHNFRENAEKARHVDDEPYGGGQGMLLRVQPIFDSFDAIEKKNPRVILLDPAGKQFDQAYAEDLAQEEELIFICGHYEGYDERIKTLVTDEISLGDYVLTGGELAAMTMIDATVRLIPEVIGKESSHQDDSFSSGLLEYPQYTRPYDYRGMVVPDVLMSGHHEKIRQWRLYESLKKTYERRPDLLEHYQLTVEEEKMLAEIKENKE
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIM14_CAEBR
Sequence: MTGGLIAAGLGLAAVGFGARYVLRNQALIKKGMEALPVAGGLNSYYRGGFDQKMSRSEAAKILGITPSAKPAKIKDAHKKVMIVNHPDRGGSPYLAAKINEAKDLMESTKS
What is the function of this protein?
Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM14, DnaJ homolog subfamily C member 21.
What is the protein family that this protein belongs to?
Belongs to the TIM14 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.