PharMolix/UniProtQA huggingface dataset:
Protein: IF2_NITEU
Sequence: MLMTQMTVEQFAHDLGMLPGLLLEQLQAAGVDKRSAADFVTEQDKTRLLDYLRKSHGSSGPRTRITLARKQTTEIKQSDSTGRPRTIEVKVKKTRVLTRQNEPEVIEKSVSEEPAPLKMVETPEPTIVKSVVDAEQMALRAEEARKRSELIARQAAELKEKQEKRRQQAAAQANVKKEPAPAEQESGPATAVTPGSVTEISSKLPETGAAATPATSTAPATTSTTAATKGHAPQKPVVKPEEKGEKKKKPTKQDAWKDEPVKRREPKARGDLSGGQEWRMRKDKHGKYKSDELQSQHAFSVPTEPVIHEVLIPETISVGALAQKMAVKAAEVIKVLMKMGSMVTINQMLDQETAMVVVEEMGHIAKIAASDNPESFLEEVDVSSDEARMEPRAPVVTVMGHVDHGKTSLLDYIRRTRVAGGEAGGITQHIGAYHVETSRGVITFLDTPGHEAFTAMRARGAKITDIVILVVAADDGVMPQTIEAIHHAKAANIPIVVAVNKMDKPEANFDRIKQELVNHGVVPEDWGGDAMFIGVSAKTGLGIDELLEAVLLQAEVLELKAVREAPAKGVVIESRLDKGRGPVATVLVQSGTLRRGDAVLTGAVFGKIRAMLNERGKSISEASTSIPVEIQGLSEVAVAGEVFIALDDERKAREIALFRQGKFRDVRLDKLQVAKMEDVFGQHEDVSTLNLIIKADVQGSCEALVYALKKLETDEVKINVVHSGVGAIIESDINLALASKAVVIGFNCRADLGARKLITSTGVDVRYYNIIYEAVDEVKKALSGMMMPDRKEKILGMVDIREIYRISKVGVVAGCYVLEGLIKRDALVRLLRDGLVIHSGSLDSLKRFKEDVREVKSGFECGLSLKNFNDIQQGDQIEVYEIVETARVL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPH_ECO57
Sequence: MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS
What is the function of this protein?
Hydrolyzes the cross-linked dimers tetrapentapeptide (D45) and tetratetrapeptide (D44).  Removes the terminal D-alanine from muropeptides and disaccharide pentapeptide M5 with a C-terminal D-Ala-D-Ala dipeptide.  Associated with recycling and remodeling of peptidoglycan (PG) (By similarity).
What are the official names of this protein?
D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH, DD-alanine-endopeptidase, DD-carboxypeptidase, Penicillin-binding protein, PBP.
What is the protein family that this protein belongs to?
Belongs to the beta-lactamase family.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: NUOH_MYCGI
Sequence: MTYPDPTLFGHDPWWLILAKSLGVFVFLLLTVLAAILIERKILGRMQLRLGPNRVGPRGLLQSLADGIKLALKEGLVPAGVDKWIYLAAPVISVIPAFMAFAVIPLGPEVSVFGHRTALQLTDLPVAVLYILAVTSIGVYGIVLAGWASGSVYPLLGGLRSSAQVISYEIAMALSFVAVFIYAGTMSTSGIVAAQNDVWFIFLLLPSFLVYLTSMVGETNRAPFDLPEAEGELVGGFHTEYSSLKFAMFMLAEYVNMTTVSALATTLFLGGWHAPWPISIADGANSDWWPLLWFTAKVWLFLFFFMWLRATLPRMRYDQFMRLGWKLLIPVSLAWIAIVATTRAMQNQGYQGWVTALIGVAGVAAILASLLAWRALRARRRRTSHSPPAQSSDHGAFPVPPLPVKEPADA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CLPP_LEPCP
Sequence: MSAVETQNLGMVPIVIEQSGRGERAYDIYSRLLRERVIFLVGPVNDQSANLVVAQLLFLESENPDKDISFYINSPGGSVSAGMSIYDTMQFIKPQVSTLCMGLAASMGAFLLAAGAKGKRFSLPNSKIMIHQPLGGAQGQATDIEIHAREILKTREQLNRILAERTGQSLEKIQNDTERDYFMSSEEAQTYGLIDQVISKRP
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_THEAC
Sequence: MTERTLVLLKPDAVKRRLIGRIISRLEDKGLKVVALKFMQMTKDQAENHYSVHRSKPFFKDLVTYITSGPIVAMVLEGPKAIEVVRILAGSTDGSKAQPGTIRGDFSMGIEKNIIHASDSPEAYSHEMPIFFNESEIVEWSYGDEIIY
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBC31_BOVIN
Sequence: MQSTDLGSKESGKIWHRKPSPATRDGIIVNIIHNTSDYLPKVLRFLNVAFDSSGDCLIAGDHHGNIYVFDLCGNRFNLVQRTAQACTALAFNLHRKSEFLVALADYSIKCFDTVTKELVSWMRGHESSVFSISVHGSGRYAITTSSDTAQLWDLDTFQRKRKLNILQSVGIQKVFFLPLSNTILSCFKDNSIFAWECDTLVCKYQLPAPPESSNILYKVFAVTRDGRILAAGGKSNHIHLWCLEAKQLFRIIQMPTKVRAIRHLEFLPDSFDAGSNQVLGVLSQDGIMRFINIQTCKLLFEIGSLDDGISSSVISPHGRYIASIMENGSLNIYSVQTLTKEINKPPPPLVKVIEDLPKKKGNSGDLKVKVTSGRVRRPARSRESKIQTRILKQDLTCGFEKKENELSDGLNKKRLQILLKGYGEFPTKYRMFIWRSLLQLPENQTAFSNLIDKGIHVAFLNLQKKYPIKSRKLLRVLQRTLSALAHWSAIFSDTPYLPLLAFPFVKLFQNNQLICFEVVATLIINWCQHWFEYFPNPPINILSMIENVLAFHDKELLQHFINHDVTSQLYAWPLLETVFSEVLTREEWLKLFDNVFSNHPSFLLMTVVAYNICSRAPLLNCKRKDDFEYFFHHRNNLDISAVIREAYRLLDTTPADIHPDSMLDAFVALTKGQYPVFNQYPKFIVDYQTQERERIRNDELDYLRERQAVEEMQAEVDQQRVEDEAWYQKQELLRRAEETRREILLQEEEKMIQQRQRLAAVRRELKVKEMHLQDAARRRLLQLQQDQREMELRRLDDEIERKVHMRDREIAATAKDLEMRHLELESQKRLYEKNLSRNQEAVAKEMKENADAYRQKVDVEEHMFHRLIGTDQTQNQKIHKLIEENLAKAEQACLNTDWRIQALHKQRCSDLHRNECYQEIAKLLRKNRKKEIEVLNAMMEGEAKKWEEAEEKDFHLKSEKKTAALSDASRRWFLEKEIHDAQHPCDKVVPKGRDEEFASGCLPRASQLNDISEMESLTQISLNQRKMHWDAMEQDLMERVRNLRQRLVTQAQNRCQTPHLLAT
What is the function of this protein?
Molecular adapter which is involved in cilium biogenesis.  Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly.  Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
What are the official names of this protein?
TBC1 domain family member 31.
Protein: GUF1_AJECH
Sequence: MRGCLQSVKWLTSALRPSQSLASSTRYPRRLLSTSAPRNAQVRKPASEVEQRIAAIPIERFRNFCIVAHVDHGKSTLSDRLLELTGTIEAGANKQVLDKLDVERERGITVKAQTCSMLYNHQGEDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDASQGIQAQTVANFYLAFAEGLKLVPVINKVDLPSADPQRALDQMKNTFELDPESAVLVSAKTGLNVSQLLPTVIEQIPAPVGDRTKPLRMLLVDSWYSTYKGVILLVRLFDGEIRAGDQVVSFATGLKYTVGEVGIMYPGRTAQSVLRAGQVGYIYFNPAMKRSQEAKVGDTYTKVGSERLVQPLPGFEEPKAMVFVAAYPVDASDFPHLEDSINQLILNDRSVTLQKESSEALGAGFRLGFLGTLHCSVFEDRLRQEHGASIIITPPTVPFKVIWKDGKEEIITNPALFPEEDTLRAKVTELQEPFVLATLTFPEEYLGRVIELCESNRGEQKSLEFFTSTQVILKYELPLAQLVDDFFGKLKGSTKGYASLDYEESGWRRSNISKLQLLVNKVPVDAVSRVVHSSQVQRLGRLWVSKFKEHVDRQMFEVVIQAAAGRNVVARESIKPFRKDVLQKLHAADVTRRKKLLEKQKEGRKKLKAVGNVVIEHKAFQAFLAK
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: THEM6_HUMAN
Sequence: MLGLLVALLALGLAVFALLDVWYLVRLPCAVLRARLLQPRVRDLLAEQRFPGRVLPSDLDLLLHMNNARYLREADFARVAHLTRCGVLGALRELRAHTVLAASCARHRRSLRLLEPFEVRTRLLGWDDRAFYLEARFVSLRDGFVCALLRFRQHLLGTSPERVVQHLCQRRVEPPELPADLQHWISYNEASSQLLRMESGLSDVTKDQ
What are the official names of this protein?
Protein THEM6, Mesenchymal stem cell protein DSCD75, Thioesterase superfamily member 6.
What is the protein family that this protein belongs to?
Belongs to the THEM6 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBC_NANDO
Sequence: METLFNGTLALAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVIDTFPYFVSGVLHLISSAVLGFGGIYHSLLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGIGAFLLVLKALYFGGVYDTWAPGGGDVRKITNLTLSPSVIFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICIFGGIWHILTKPFAWARRALVWSGEAYLSYSLAALSIFGFTACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLATSHFVLGFFLFVGHLWHAGRARAAAAGFEKGIDRDLEPVLFMTPLN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ACCD_XANCB
Sequence: MSWLSKLMPSGIRTENTPAKKRSVPEGLWEKCSNCGSALYGPELEENLEVCPKCDHHMAIRARARLAALFDVDSPPTEIAAQLGPVDVLKFKDQKKYGERIKASQKSSGEYDALIAMRGMLKGNPLVAAAFDFAFMGGSMGSVVGERFARAAEVALEVGCPFVCFSASGGARMQEGLFSLMQMAKTSAALGRLREAGLPYISVLTHPTTGGVSASFAMLGDINIAEPHALIGFAGPRVIEQTVRETLPEGFQRSEFLLDHGAIDQICDRRDMRDRIAELTTMMMRQPHPQDADAA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIBB_CAMDR
Sequence: ATDYDEEEDDRVKVRLDAR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: ITR1_MOMCH
Sequence: ERRCPRILKQCKRDSDCPGECICMAHGFCG
What is the function of this protein?
Inhibits trypsin.
What are the official names of this protein?
Trypsin inhibitor 1, MCTI-I, Trypsin inhibitor I.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I7 (squash-type serine protease inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: IF1A1_METBF
Sequence: MPATQEVTRVRTPRRENHEVLATVSSLLGSKRVTLQCMDGVVRMGRIPGSKNKKMWIHEGDVVIVAPWDIQDSKADVIWKYTRPQVEWLERKGYLK
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
What are the official names of this protein?
Translation initiation factor 1A 1, aIF-1A 1.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.
Protein: CDX2_MOUSE
Sequence: MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAATANLDSAQSPGPSWPTAYGAPLREDWNGYAPGGAAAANAVAHGLNGGSPAAAMGYSSPAEYHAHHHPHHHPHHPAASPSCASGLLQTLNLGPPGPAATAAAEQLSPSGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERKIKKKQQQQQQQQQQQPPQPPPQPSQPQPGALRSVPEPLSPVTSLQGSVPGSVPGVLGPAGGVLNSTVTQ
What is the function of this protein?
Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (PubMed:9933478, PubMed:16027724).  Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (PubMed:7935448).  Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (PubMed:9933478).  Binds to and activates transcription of LPH (By similarity).  Activates transcription of CLDN2 and intestinal mucin MUC2 (PubMed:16027724).  Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (PubMed:9512360).  Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.  Binds preferentially to methylated DNA (By similarity).
What are the official names of this protein?
Homeobox protein CDX-2, Caudal-type homeobox protein 2.
What is the protein family that this protein belongs to?
Belongs to the Caudal homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNME_PORGI
Sequence: MSILHSFNKDTICAVATAPGVGGIAVIRVSGADAFRLVSPLFLYRGKAIDLSGAKPRTALYGEIMEADELIDEVILTCFHGPHSFTAEHTVEIACHGSIYIRRRILEALINQGCRLAQPGEFTRRAYLNGRMDLSSAEAVADIIASESKAQHQMAMKQLRGGYSEELNALREELLRLTGLMELELDFPEEDVEFADRTELLALCDQIELKLKKLIDSYRLGNAVKRGIPVAIVGTTNVGKSTLLNTLLGEERAIVSDIHGTTRDTIEDTMHIGGYLFRFVDTAGLRETEDTIESLGIERSRSKIKEADIILAVVDGTRISEANQLDYIKSIWDEREERTLILLVNKSESLAEADRIGLSETLQTKLSTPTKPIFISAREGRGIDELKGELTQIMETSGANEADLIVSNARHHQLLREAFDALRRMRLGFDMGLSTDLLTLDLRHAITSIGEITGREITSDDTLHYIFAHFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FZO1_CAEEL
Sequence: MSGTASLVHTLPASGDSNHRGLHSLKNSRRAADNEPLLRFREAKKVLGDVYGELKDNVAELEGVYKDIKENDFVSSEQREEIEAIGDSIKTIMDTFQRDNMKVVFFGRTSNGKSTTINAMLHEKVLPQGMGHTTCCFLQVEGSEGEVGHLQLDDNPQKIDMKMLGKIGHALSDENSDLPAMGQDSLLKVFHPKKSESGECRLLQNDVVILDSPGVDLSPEFDSWIDKHCLDADVFVLVSNAESTLTQAEKNFFLRVAKKLSKPNVFILNNRWDASAAETENIEDVKKQHLTRFRQFLVDELEVCSEREVNDRIFFVSSREVLESRLKARGLVQKAYQAEGHGTRALEFQNFERHFEHCISRSAIHTKFEAHNRRAHEMIGKMRLNLNSVLTSAAEQRSKLQNNLNESTRTFNECRVNFTQFEKAYREQTEQLRAEVHLKVSADFFEEIARLDAIIDRFEQPFDGSSSGMTKYKEDLAIFVDKCLSSDLEARCTGGLMSRIWNLENDMFQYVTKILAEPYQNKLEEVWRYRAPFKFSICVDVPALVNDFHEDLEFRFTFGLHAIIRRIIAYRSGQPVTAINTNLLTPLSLKQQSEKNSVRDAEASAASEEQAMMTQMVLTSAAFLANGSLGVLVVGGIVYKAVGWRVIAVGGAAYAGLYAWERMRWNSGAKEQHLKEQFRSHLAARMQQVSTAHTHHCETQAIREMDQVFDGLKATVGGVHREMKNDLDVQKTQIDAVDSTIRTLGTIKGKAVFLLRNLEQFASSYLRSDSPPTP
What is the function of this protein?
Probable transmembrane GTPase (By similarity).  Mediates mitochondrial fusion (PubMed:21248201, PubMed:25190516, PubMed:19327994, PubMed:18722182, PubMed:33734301).  Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (By similarity).  Dispensable for normal apoptotic processes during embryonic development (PubMed:18722182).
What are the official names of this protein?
Transmembrane GTPase fzo-1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: SYP_XANOM
Sequence: MRLSQFHLHTTKETPADAELVSHRLMLRAGMIRKLASGLYTWSPLGLRVLRKVEAIVREEMDRAGAVEVLFPTIQPRELWDATGRWEKFGGQLLKIKDRKEQEFCYSPTAEEAAAEFARQEINSYKQLPLNFYQIQTKFRDEIRPRFGVMRAREFLMKDAYSFHLTDADMAREYDNMRAAYTRIFTRLGLDFRAVQADSGAIGGDASQEFHVIADSGEDSLAFSTGSDYAANVETASAALPAPRAAASEAMQQVATPTQKTCEDVAQLLGIALQRTVKSVAVMTEAGFVLALVRGDHAVNEIKLAKVPGLAGYRLANETEIRAHLGCEPGFLGPVNTARPVRVVADRDVAALADFVVGANVSGAHLVGVNWGRDLPEPETVADVRNVVEGERAADGGELRLARGIEVGHVFQLGSQYAQALQATVIDEGGKVAVMKMGCYGIGISRIVAAAIEQNHDDAGIIWPAPMAPWQVVVCVINPKQDAQVVSAAQALLDELIAAGLDAALDDRGLRPGAMFADMELLGIPHRVVVSERGLAAGTFEYRARTAAAAENLDKAGLFSRLGR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FSTL1_RAT
Sequence: MWKRWLALALVTIALVHGEEEQRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQANRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKSFDNGDSHLDSSEFLKFVEQNETAVNITAYPNQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCSCGHWVCTAMTCDGKNQKGVQTHTEEEMTRYAQELQKHQGTAEKTKKVNTKEI
What is the function of this protein?
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity).  Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter.  Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner.  Also promotes survival of cardiac myocytes (By similarity).  Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity).
What are the official names of this protein?
Follistatin-related protein 1, Follistatin-like protein 1.
What are the subcellular locations of this protein?
Secreted.
Protein: MED8_EMENI
Sequence: MTTLSPDHLKTLEQSRQRLIQLTHSLGSLITSLNQSDPLPTWSSLQTQASIISNNLQSISTHLSENHELLRSISALPAPEFPTKTHANTLEQLLRTKLDPRVEDWVSRGRKADNSAIQGSSGSTGMFSTLPSASAAGMNAGVVGAGAGGRLSEDDLAALWEWAPVEANSEARRRNWGGNFTLEEKERGIQQVVAELGLKRVLEDDDESEEEDEEMDVGFGGRIDGAPDNAGAAAGEHALPLVPINEILRYMTTGVMPAVR
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 8, Mediator complex subunit 8.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 8 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRUB_HAEIE
Sequence: MSRPRKRWRDVDGVFLLDKPQGMSSNDIMQKVKRLFQANKAGHTGALDPLATGMLPICLGEATKFSQFLLDADKRYLVTAKLGERTDTSDAEGQVVETREVHVETPQILTALEQFRGDILQVPTMFSALKHNGKPLYEYARQGITVEREARPITIFELNFIEYHAPFLTLEVHCSKGTYIRTLVDDLGEVLGCGAHVTMLRRTAVADYPVAEMMPINELQLLAESFPLSELDRLLLPTDTAVSKLPALHLDVEQSKAIGFGQRVKFANEQQLSGQVRLFSAENLFLGVALIDGNIIRPQRLITQSA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: MDH_METPB
Sequence: MARSKIALIGAGQIGGTLAHLAGLKELGDVVLFDIVDGVPQGKALDIAESAPVDGFDAKYSGASDYSAIAGADVVIVTAGVPRKPGMSRDDLIGINLKVMEAVGAGIKEHAPNAFVICITNPLDAMVWALQKFSGLPTNKVVGMAGVLDSARFRHFLAEEFGVSVEDVTAFVLGGHGDDMVPLTRYSTVAGVPLTDLVKLGWTTQEKLDAMVERTRKGGGEIVNLLKTGSAFYAPASSAIAMAESYLRDKKRVLPCAAYLAGEYGVDGLYVGVPVVIGENGVERVLEVTFNEDEKAMFEKSVGAVKGLIAACQGINDKLA
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: MDS_AGACL
Sequence: MDFLKKSLFLVVFLGLVSLSVCEEEKRESEEEKNEQEEDDREERSEEKRLLGMIPLAISAISALSKLG
What is the function of this protein?
Antimicrobial peptide with activity against Gram-positive bacteria (S. aureus, MIC=8 uM) and fungi (C. albicans, MIC=32 uM) (PubMed:23415652).  Shows anticancer activities (By similarity).  Shows weak hemolytic activity (PubMed:23415652).
What are the official names of this protein?
Medusin-C1, MDS-C1, Medusin-AC, Phyllin-AC.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Medusin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YJGM_SALTY
Sequence: MNNVASPTLTVRRITTADNAAIARVIRQVSAEYGLTADKGYTVADPNLDELYQVYSQPGAAYWVVEQNGCVVGGGGVAPLSCSEPDICELQKMYFLPVIRGQGLAKKLALMALDHAREQGFKRCYLETTAFLREAIALYERLGFEHISEPLGCTGHVDCEVRMLKDL
What are the official names of this protein?
Uncharacterized N-acetyltransferase YjgM.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: YMF17_MARPO
Sequence: MKTHRETLGHWLLQRITAAFLIPTILIANVSTLILLNILLFWHIHVGIEEILADYVHHEVTRNWILILLRVFCLIIIKYVFVFFVF
What are the official names of this protein?
Uncharacterized mitochondrial protein ymf17, ORF86A.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RBSD_VIBCH
Sequence: MKKSTLLNSELSYLVATLGHTDEITICDAGLPIPDEVTRIDLALTHGVPSFLETVRVILSESQIESVIVAQEFAQVSPVLHEALYRELKAEEQLCGKPIAIQYISHEAFKQRTLQSRAVVRTGECTPYANVIFQAGVVF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.