PharMolix/UniProtQA huggingface dataset:
Protein: ASAI_AERSA
Sequence: MLVFKGKLKEHPRWEVENELYRFRNRVFSDRLGWDVESHRGLEQDSFDTPDTHWVLIEDEEGLCGCIRLLSCAQDYMLPSIFPTALAGEAPPRSSDVWELTRLAIDANRAPRMGNGVSELTCVIFREVYAFARAKGIRELVAVVSLPVERIFRRLGLPIERLGHRQAVDLGAVRGVGIRFHLDERFARAVGHPMQGEYADARELVTE
What is the function of this protein?
Required for the synthesis of N-butanoyl-L-homoserine lactone (BHL), an autoinducer molecule which binds to AsaR.
What are the official names of this protein?
Acyl-homoserine-lactone synthase, Autoinducer synthesis protein AsaI.
What is the protein family that this protein belongs to?
Belongs to the autoinducer synthase family.
Protein: GCS2_SALSV
Sequence: MTLNDFHVSEPYTLGIELEMQVINPPGYDLSQDSSTLIDAVKPQLTAGEIKHDITESMLEMATGVCRDIDQAAAQLSAMQHVILQAASEHHLGICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCANGDDAIYLLHGLSHFVPHFIALSAASPYMQGSDTRFACARLNIFSAFPDNGPMPWVSNWQEFAGLFRRLSYTTMIDSIKDLHWDIRPSPAFGTVEVRVMDTPLTLDHAINMAGLIQATAHWLLTERPFKPQEQDYLLYKFNRFQACRYGLEGVLTDAYTGDRRRLADDTLRLLDNVTPSARKLGADSAIDALRLQVKKGGNEAQYMREFIADGGSLIGLVQKHCEIWAGQ
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: GRPE_STRPJ
Sequence: MAQDIKNEEVEEVQEEEVVETAEETTPEKSELDLANERADEFENKYLRAHAEMQNIQRRANEERQNLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLGMVQESLIHALKEEGIEEIAADGEFDHNYHMAIQTLPADDEHPVDTIAQVFQKGYKLHDRILRPAMVVVYN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP4C_PONAB
Sequence: MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL
What is the function of this protein?
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration.  The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.  The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA DSB repair.  Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity).  In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 catalytic subunit, PP4C, Pp4.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: WNT11_MOUSE
Sequence: MRARPQVCEALLFALALHTGVCYGIKWLALSKTPAALALNQTQHCKQLEGLVSAQVQLCRSNLELMRTIVHAARGAMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAATISHTIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLETKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Probable developmental protein.  May be a signaling molecule which affects the development of discrete regions of tissues.  Is likely to signal over only few cell diameters.
What are the official names of this protein?
Protein Wnt-11.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: EPSK_VIBCH
Sequence: MRAKQRGVALIVILLLLAVMVSIAATMAERLFSQFQRATHQLNYQQAYWYSLGVEALAKKGIEQSYQDSETINLSQPWALKEQTYPLDYGQVRGKIRDMQACFNLNALAGVKLTPDSVKKPYLLTVLQALLEGLEVESYQAEVIADSTLEFIDKDDSVRTAYGVEDSYYESMIPAYMAADTWLADASEWRAVQQVGGETMNKALPYVCALPTDQWRLNVNTLPAEQAALLAAMFSPTLSPESAKTLLEGRPFDGWASVDDFLAQSALTGVDNAVREEAKKYLSVDSHYFELDAQVLVDTSRVRIRSLFYSNDKKTATVIRRRFGGISERVSDRSTE
What is the function of this protein?
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Plays a role in pseudopilus assembly and seems to control its length.  Interacts with the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.
What are the official names of this protein?
Type II secretion system protein K, T2SS protein K, Cholera toxin secretion protein EpsK, General secretion pathway protein K.
What is the protein family that this protein belongs to?
Belongs to the GSP K family.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: UPPP_PSEAB
Sequence: MEWWTAFQAFILGVVEGLTEFLPISSTGHQIIVADLIGFGGERAKAFNIIIQLAAILAVVWEFRGKIFQVVRDLPSQRQAQRFTANLLIAFFPAVVLGVLFADLIHEWLFNPITVALALVVGGVVMLWAERRKHVIHAEHVDDMTWKDALKIGCAQCLAMVPGTSRSGATIIGGLLFGLSRKAATEFSFFLAMPTMVGAAVYSGYKYRDLFRPEDLPVFAVGFVTSFVFAMVAVRALLKFIGNHSYAAFAWYRIAFGLLILATWQFHLIDWSTAGEM
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MOAA1_PSEAE
Sequence: MTDWIDGQGRQIDYLRLSVTDRCDFRCVYCMAEDMRFLPRQQVLTLEEIERVARLFVAGGVRKLRLTGGEPLVRPGIVGLCERLAALPGLRELCMTSNGSQLVRYARPLYDAGLSRLNISLDTLDPLRFRAITRNGELDKVLAGIDAAQAAGFRRIKLNAVVMKGRNADEVPALVDFAIARGLDISFIEEMPLGQVGRERGESFCSSDEVRALIAQRHALLDSAEQSGGPARYVRLVEHPQTRIGFISPHSHNFCATCNRLRLTVEGRLLLCLGHEHSLDLRALLRRHPLHDGPLLEAIGEALQRKPARHEFSAAGEVQVLRFMNMSGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase 1, Molybdenum cofactor biosynthesis protein A 1.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: SECA_STUS1
Sequence: MFAPLLKKLFGSKNEREVKRMLKAVQSVNALEEQMLSLSDEQLRSKTEEFKARLEKGETLDQILPEAFAVCREAGKRVMGMRHFDVQLIGGMTLHEGRIAEMRTGEGKTLVATLAVYLNALAGKGVHVVTVNDYLARRDANWMRPLYEFLGLSVGIVTPFQPPEEKRAAYASDITYGTNNEFGFDYLRDNMAFSLQEKNQRELNFAVIDEVDSILIDEARTPLIISGQAEDSSKLYQQINLLIPRLTQHIEEEEGVVTQEGHFSIDEKTRQVELNEQGHQYIEELLTQAGLLAEGESLYSAHNLGLLTHVYSGLRAHKLFHRNVEYIVQNNQVLLIDEHTGRTMPGRRLSEGLHQAIEAKEGLQIQPESQTLASTTFQNYFRLYKKLAGMTGTADTEAFEFQQIYSLPVVVIPTNKPLARKDFNDLVYLTQEEKFAAIIADIKECRNQGRPVLVGTATIESSEYVSRLLEAEGFEHKVLNAKHHDKEAEIIAQAGRPGAVTIATNMAGRGTDILLGGNWEVEVAALENATEEQIAQIKADWQKRHQQVLEAGGLHVIASERHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDSLMRIFASDRVKNFMKALGMESGEAIEHRMVTNAIEKAQRKVEGRNFDMRKQLLEYDDVANEQRKVIYHMRNSLLAADEIGQTIAEFRQEALDAAISAHIPPQSLPEQWDIPGLEAVLYSDFGTRLPIQQWLDEDEKLYEETLREKILQALLDAYNEKEDMAGAEALRSFEKQIVLRVLDDLWKDHLSTMDHLRHGIHLRGYAQKNPKQEYKRESFTLFQDLLESIKRDSIRVLSHVQVRREDPAEEEARLRHEAEELAKRMQFQHAEVSALDQPEEEPAEVEGQPDVAVASVRTEPKIGRNEPCPCGSGKKYKHCHGQVQ
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
Protein: RBM42_HUMAN
Sequence: MAGAGPAPGLPGAGGPVVPGPGAGIPGKSGEERLKEMEAEMALFEQEVLGAPVPGIPTAVPAVPTVPTVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPGDRSHLDSPEAREAMFLRRAAVAPQRAPILRPAFVPHVLQRADSALSSAAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPAAPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLGEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR
What is the function of this protein?
Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA.
What are the official names of this protein?
RNA-binding protein 42, RNA-binding motif protein 42.
What is the protein family that this protein belongs to?
Belongs to the RRM RBM42 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Upon stress response, localizes with HNRNPK in cytoplasmic aggregates of stalled translational preinitiation complexes called stress granules.
Protein: RL32_EHRRW
Sequence: MAVPKRKKSKSRRNMHRSHCKLKVPNIGIDKTTGEYKLSHHICLGGYYNGKQIVEVDSNI
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: NU4M_ATRPI
Sequence: PIAGSMVLAAILLKLGGYGIIRMMQILPTTKTDMFLPFIVLALWGAILANLTCLQQTDLKSLIAYSSISHMGLVVAAIIIQTPWGLTGAMTLMIAHGFTSSALFCLANTTYERTHTRILILTRGFHNILPMTTTWWLLANLMNIATPPTLNFTSELLIMSTLFNWCPTTIILLGLSMLITASYSLHMFLSTQMGPTPLNNQTEPTHSREHLLMALHLIPLMMISMKPELII
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: 3SO62_NAJHH
Sequence: FTCFTTPSDTSETCPDGQNICYEKRWNSHQGVEIKGCVASCPEFESRFRYLLCCRIDNCNK
What are the official names of this protein?
Weak toxin CM-2.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group VI sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RRP4_THEAM
Sequence: MKLKVIVADRQLVRPGDILAYIEEAGEVVKFKKIPDKHVYIFDNKIISDLVGVVNVSGEDIQVIPLEGVYIPRKDDLVIGIVENVGVTAWTLDIRSPYPGVLNASEVIEGFNPLIHNLRNYLDTGDFVIGRIALFDRTRDPVITVKGKGLGKITEGVVVDVKPSKIPRLIGKRGSMYNLLTSMSGCEITIAQNGFVWLKCHDENRAKVLIQAIKLIELKAHMRGLTEEVKMFLERKLGGGGSGEHQA
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Increases the RNA binding and the efficiency of RNA degradation.  Confers strong poly(A) specificity to the exosome.
What are the official names of this protein?
Exosome complex component Rrp4.
What is the protein family that this protein belongs to?
Belongs to the RRP4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLMA_PECCP
Sequence: MAEKESTKRNRREEILQALAQMLESSDGSQRITTAKLAANVGVSEAALYRHFPSKTRMFDSLIEFIEDSLTTRINLILQDEKETFNRLRLILLLILGFAERNPGLTRIMTGHALMFEQDRLQDRINQLFERIESQLRQVLREHKLRDGKGFQHDETLLASQLLAFCEGMLSRFIRSEFRYRPTQEFDTRWPLLAAQLN
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: 14310_ARATH
Sequence: MENEREKQVYLAKLSEQTERYDEMVEAMKKVAQLDVELTVEERNLVSVGYKNVIGARRASWRILSSIEQKEESKGNDENVKRLKNYRKRVEDELAKVCNDILSVIDKHLIPSSNAVESTVFFYKMKGDYYRYLAEFSSGAERKEAADQSLEAYKAAVAAAENGLAPTHPVRLGLALNFSVFYYEILNSPESACQLAKQAFDDAIAELDSLNEESYKDSTLIMQLLRDNLTLWTSDLNEEGDERTKGADEPQDEN
What is the function of this protein?
Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.
What are the official names of this protein?
14-3-3-like protein GF14 epsilon, General regulatory factor 10.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Translocates from the cytosol to the nucleus when phosphorylated.
Protein: RF1_HAHCH
Sequence: MKESIKLKLDLLKDRYEEVGALLSDPDIISVQEKFKELSKEYAELEPVVQCYQEYQNALNAIEESKLLLNDSDADMREMAKEELAAAEESSEQLEKDLQILLLPRDPRDGSNVFLEIRAGTGGDEAAIFAGDLFRMYSRYAELKKWKVEIVSESPGEHGGYKEVISRVAGDNVFNLLKFESGAHRVQRVPETESQGRIHTSACTVAILPEVEEVGDVDINPADLRVDTYRASGAGGQHVNKTDSAIRITHLPSGIVVECQDERSQHKNRAKAMSLLKAKLLSSAQEKQAKEQAQTRKSLVGSGDRSERIRTYNYPQGRITDHRINLTLYKLEEVVQGDLDPVIQPLLQEYQAEMLASISE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSJ_SALAR
Sequence: MTTQAPLTGLLPLNPQQLARLQAATTDFTPEQLAWVSGYFWGVLNPRSGADAVARAPERGSLGITLISASQTGNARRVAEALRDDLLAVNLNVNLVNAGDYKFKQIACEKLLVVVTSTQGEGEPPEEAVALHKFLFSKKAPRLNNTAFAVFSLGDTSYEFFCQAGKDFDNKLAELGGERLLDRVDADVEYQTVAAQWRARIVDVLKSRTPVTTPVPSVVSGAVNEIHTSPYTKEAPLRASLSVNQKITGRNSEKDVRHIEIDLGDSGLCYQPGDALGVWYQNDPALVKEIVELLWLKGDEPVAVDGKLLPLTEALQWHFELTVNTAGIVENYATLTRSEFLLPLVGDKAQLQHYAAATPIADMLRFSPSQLDADALVGLLRPLTPRLYSIASSQAEVENEVHLTVGVVRYDIEGRARAGGASSFLADRVDDEGEVRVFIEHNDNFRLPTNPETPIIMIGSGTGIAPFRAFIQQRAADEASGKNWLFFGNPHFTEDFLYQVEWQRYVKEGLLSRIDLAWSRDQKEKIYVQDKLRERGAELWRWINDGAHIYVCGDANRMAKDVEQALLEVIVEFGGMDLESADEYLSELRVARRYQRDVY
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.  The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein alpha-component, SiR-FP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: NUDJ_SHIF8
Sequence: MFKPHVTVACVVHAEGKFLVVEETINGKALWNQPAGHLEADETLVEAAARELWEETGISAQPQHFIRMHQWIAPDKTPFLRFLFAIELEQICPTQPHDSDIDCCRWVSAEEILQASNLRSPLVAESIRCYQSGQRYPLEMIGDFNWPFTKGVI
What are the official names of this protein?
Phosphatase NudJ.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudJ subfamily.
Protein: FPG_METCA
Sequence: MPELPEVETTRRGIAPHIAGWRIVDVRVREARLRWPVPADLGETLTGRRLTDVRRRGKYLLLDFDEGTLIAHLGMSGSLRICKPGFPPRKHDHVDLVFEGDICLRYHDPRRFGCLLWTAEPPERHPLLAALGPEPLDKAFDGAHLHRLAAGRNTAVKSFIMDSRVVAGVGNIYANEALFRAGIHPARPAGKISLARYRNLGEHIAEVLAASIEQGGTTLRDFVNESGAPGYFKQVLRVYDRAGQPCRVCGEPIRCVRLGQRATYYCPRCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: PROB_ALCBS
Sequence: MADRQRWVIKIGSALLTNDGKGLDCALMQTWVDRMVALRERGIEVVIVSSGAVAEGMTRLGWSARPDSVHELQAAAAVGQMGLVQAWETRFQQHQLHTAQVLLTHDDLSDRKRYLNARSTLLTLLGFGVVPVVNENDTVVTDEIRFGDNDTLAALVANLVEADRLLILTDQEGLFDADPRSNADANLIREARASDPAIVRVAGGGGLLGRGGMATKVRAGKLAARSGAITTIASGRSPEVLIELADGQGPGTTLLPDTTPMNARKQWLAGHLQMRGRLVLDAGAVVRLREGGSSLLPVGVVDVFGQFSRGEMVACEDERGERVGCGLVNYDAADARRICRKKSAEIAGVLGFMNEEELIHRDNLVLMEAGSRVSGA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_COREF
Sequence: MTAIPTPYEDLLRTIRDEGAHKDDRTGTGTTSLFGQQIRYNLQEGFPLLTTKKVHFHSVVGELLWFLRGDSNVRWLQDNNIRIWNEWADEDGELGPVYGVQWRSWPTPDGRHIDQISRALEMLKNNPDSRRNIVSAWNVSELENMALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQADLEVGEFIWTGGDCHIYDNHTEQVDEQLSRAARPYPTLELNKAASLFDYTFEDIAVSNYDPHPLIRGKVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_BUCAI
Sequence: MARYFRRRKFCRFTAEGVQEIDYKDIAVLKNYITESGKIVPSRITGTRAKYQRQLSRAIKRARYLALLPYTDQHR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: TJB16_HUMAN
Sequence: SYNSPLHFGNGTRLTVT
What is the function of this protein?
J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta joining 1-6.
What are the subcellular locations of this protein?
Cell membrane.
Protein: CECC_DROTK
Sequence: MNFNKIFVFVALILAISLGQSEAGWLKKLGKRIERIGQHTRDATIQGLGIAQQAANVAATARG
What is the function of this protein?
Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Cecropin-C.
What is the protein family that this protein belongs to?
Belongs to the cecropin family.
What are the subcellular locations of this protein?
Secreted.
Protein: COAX_MOOTA
Sequence: MLLAIDVGNTNIVLGIFAGHELKCHWRVASDRQKTADEYGLILRQLAHYQGLDLKEIQGVVLASVVPTLTQVLTEMITKQLGHQPLVIGPGVKTGMPIRFENPREVGADRIVNGVAVYELYGGPAIVVDFGTATTFDAISEKGEYLGGAIAPGIGIATDALFARAAKLPRVELVRPPRLIGKNTVACMQAGIMYGFIGQVEGIITRMQAEMGGKAIVVATGGLAGLIGPEVNCIDRVDPMLTLEGLRIVYERNT
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRM1_CHAGB
Sequence: MFYNEKTGAVPPVPSNLNANTWHTVDLQPAPQLQPHAHTAPTVTPYLGLRARLSQLWFNRWTILLILVLVRVLILTAGLNDNIGDAKTKALSACTKVEDIGSAMASMPHYLSVGVNSMAADGITKTVSGMVKMLMMILTGVENLILFIINMYVGTYACLIAALIHGGLDVSVKVVEGATKVMNDAIGTITGQITESISDVQDAINKIPDTISSFLGGVDFDLPKIDITKNLDDLENIKINSNELVRDIVALNKTIPTFDQVENFTKNAIAIPFNFLKEQVNSSFGSYKFDDSVFPVAEKQALSFCSNNSFLNDFFETLFNVVRTAKIAFCVAIPILAVLAIVGMGYLEIQRWRREKQRSREFTERGYDPMDVVYLSSRPVTGGFGLWLSAKFKSVKKQLLVRWTIAYGTSLPALFVLSLAFAGLFSCLCQFIILRSIQKEAPALANQVGDFAGDVVGTLQQVSTNWADDANGVIIKLQDDINDDMFGWVSNATTAVNDTLNTFDDEIDKAITAVFKDTILFNTARNLVGCLITRKIETVQEGLTWVHDNAHVTLPLFANDVFSQGANNSVNGDSDLTSFLASPSSVTTDEITSAVNQVITKLEHGIVQEALISTALLLVYVIVVLSGAVRALVASAQKEKTRGEGGEQYGVKAPGSRGSSSASSGNSDNHHYHHHHDNSAPSDFDRKGVIYAGSVKRGRPGPERWPSHARKSSYPEVEGPDH
What is the function of this protein?
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
What are the official names of this protein?
Plasma membrane fusion protein PRM1.
What is the protein family that this protein belongs to?
Belongs to the PRM1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.