PharMolix/UniProtQA huggingface dataset:
Protein: KSG8_ARATH
Sequence: MNVMRRLKSIASGRTSISSDPGGDYALKRAKLDQENDNLCVDPMQVDQNSSCFEMKADVLSQESVAGTSNVPAVSEKPVDDQLPDVMIEMKIRDERNANREDKDMETTVVNGSGTETGQVITTTVGGRDGKPKQTISYMAQRVVGTGSFGVVFQAKCLETGEQVAIKKVLQDKRYKNRELQIMRLQDHPNVVRLRHSFFSTTDKDELYLNLVLEYVPETVYRASKHYTKMNQHMPIIFVQLYTYQICRALNYLHRVVGVCHRDIKPQNLLVNPQTHQLKICDFGSAKMLVPGEPNISYICSRYYRAPELIFGATEYTNAIDMWSGGCVMAELLLGQPLFPGESGIDQLVEIIKILGTPTREEIRCMNPNYTEFKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRCTALEACAHPFFDDLRDPNVSLPNGRALPPLFNFTAQELAGASTELRQRLIPAHCQGTGSSS
What is the function of this protein?
May mediate extracellular signals to regulate transcription in differentiating cells.
What are the official names of this protein?
Shaggy-related protein kinase theta, ASK-theta, Shaggy-related protein kinase 32, AtSK32.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Protein: PTH_MYCVP
Sequence: MAEPVLVVGLGNPGPQYATTRHNAGFMVVDILADRMGEKFKVHKKSGAEVATGRLAGRPVVLAKPRVYMNESGRQVGPLAKFYSVAPADVVIVHDELDIDFGRIRLKAGGGVAGHNGLRSVASALGGNDFQRVRVGIGRPPGHKSGASFVLENFNSVERKEVPTILEQAADATELLVAQGLEPAQNTVHAWG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MERR_STRLI
Sequence: MKSPALAGSLATAEVPCTHPDTTARFFRALADPTRLKLLQFILRGERTSAECVEHAGISQPRVSVHLSCLVDCGYVSARRDGKKLRYSVGDPRVADLVMLARCLAADNAAALDCCTRIPGEGEQR
What is the function of this protein?
Negatively regulates the mercuric reductase merA and the organolyase merB in the absence of mercuric ions.
What are the official names of this protein?
Probable mercury resistance operon repressor.
Protein: MUTS_SHEHH
Sequence: MTAIDPQGLEKHTPMMRQYLTLKAQHPDMLLFYRMGDFYELFYEDAKRASELLGISLTARGKSGGDPIPMAGLPYHAVEGYLAKLVQLRVSVAICEQIGDPATSKGPVERKVVRIVTPGTLTDEALLQERQDNLLAALYQGKTGYGYATLDVASGRFVITELANTEALEAELQRTNPAELLYSEDFSEMSLIAAINGTRRRPEWEFDYDTCHRLLLNQFGTKDLKGFGIEDARLSLQAAGCLMQYVKDTQRTALPHINSIVRFNQSDSIVLDAATRRNLELTVNLQGGRENTLASVLDNTVTPMGSRMLQRWLHQPLRDHDIIRARQVSIEELLGNANYEILSEDLKAIGDIERITTRIALRNARPRDFARLRQALALLPQLQQTLTQAAAPHLKYLSQVIGEFPDELELLSRAVVDNPPMLIRDGGVIREGYNEELDQWRKLSEGATDYLHELEAREKQQTGISTLKVGYNRVHGYYIEVSRRESDLVPLSYQRRQTLKNTERYIIPELKEHEEKVLSSQGRALALEKQLWEQLFDLILPKLHELQDFARASAELDVLCNFAERAESLNYHCPDLSTAPGIQIEAGRHPVVEQVSQSPFIANPVTLNNERKMLIVTGPNMGGKSTYMRQVALITLMAHIGCYVPAEHAVIGPVDRIFTRIGASDDLASGRSTFMVEMTETANILHNATPNSLVLMDEIGRGTSTYDGLSLAWSAAEYLAKHLQAMTLFATHYFELTQLPELLSNVENVHLDAVEHGDSIVFMHAVQEGAASRSYGLQVAALAGVPNCVISAAKHKLHQLESRDHGKESCDAQQPLQQSISFSAPTPSPALEALAKLNPDELTPRQALDYLYNLKKLAL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: TM270_MOUSE
Sequence: MEAAPRVRSGLLRILLRAGRLSALLIQNRTHLYRFLLLKMAIFQHWVLGLAQEARGSGSDQARQLPEVIITCALSLALRAGLTLLWVPMWLLLWGPRLAYRVGLCCTRTVRLALGHLCVCEPLGLSPATFRDLFLSCLHSLMLVALLLLLLTWKLMQKAHHFSLGWLPSQNSVLLEAPALLRRLYLWVEHRTTLTSWNLAYLVTWTTCLASHLLQAAFEHTTQLAQAQEVKSQETSGPPPQFLIPESSTTESGPLPPQPETPGE
What are the official names of this protein?
Transmembrane protein 270.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DNAK_XANCB
Sequence: MGKIIGIDLGTTNSCVAIMDGGKARVIENSEGDRTTPSIVAYTKDGEVLVGASAKRQAVTNPKNTFYAVKRLIGRKFTDGEVQKDISHVPYGILAHDNGDAWVQTSDSKRMAPQEISARVLEKMKKTAEDFLGEKVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKNGGDRKIAVYDLGGGTFDVSIIEIAEVDGEKQFEVLATNGDTFLGGEDFDNRVIEYLVDEFNKDQGIDLRKDPLALQRLKDAAERAKIELSTSQQTEVNLPYVTADASGPKHLNIKLTRAKLEALVEDLVKKSIEPCRTALNDAGLRASDINEVILVGGQTRMPKVQQAVADFFGKEPRKDVNPDEAVAVGAAIQGGVLAGDVKDVLLLDVTPLSLGIETMGGVFTKIIEKNTTIPTKASQTFSTAEDNQSAVTVHVLQGEREQARFNKSLAKFDLSGIEPAPRGMPQVEVSFDIDANGILHVSAKDKKTNKEQKVEIKAGSGLSDEEIQRMVADAEANREEDKKFQELVQTRNQADGLIHATRTAITEHGSKVGGDVIGKVEAALADLETAMKGDDKAQIEARSKTLEEAGQSLYAAAAAAEQGGNADAASGNAQASKAADDVVDAEFTEVKDDKKA
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: LEXA_SODGM
Sequence: MKALTTRQKEVFDLIRDHITQTGMPPTRAEIASRLGFRSPNAAEEHLKALARKGAIEIVSGASRGIRLMIEEESGLPLIGRVAAGEPLLATQHIESHYQVDPALFKPHADFLLRVSGMSMKDIGIMDGDLLAVHKTQDACNGQVVVARIDDDVTVKRLKRQGNIVELLPENSEFDPIVVDLRQQELTIEGLAVGVIRNGNWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: OBP1_HELVI
Sequence: MPGVLRALLLLAAAAPLLADVNVMKDVTLGFGQALDKCREESQLTEEKMEEFFHFWRDDFKFEHRELGCAIQCMSRHFNLLTDSSRMHHDNTEKFIQSFPNGEVLARQMVELIHSCEKQFDHEEDHCWRISHLADCFKSSCVQRGIAPSMELMMTEFIMEAEAR
What is the function of this protein?
Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
What are the official names of this protein?
General odorant-binding protein 1, GOBP 1.
What is the protein family that this protein belongs to?
Belongs to the PBP/GOBP family.
Protein: GLND_BRASB
Sequence: MDSVTPNSRPESFPEFDSAGLAAAVDALAAQHSGREDMFRAAVVQLLKAELVKARAVAQAQLLKDRHGRRCAERLCFVQDEIIRILYAAATQHLYRSQVPSGAERMAVVATGGYGRGLMAPESDIDLLFILPYKQTAWGEQVAEAILYSLWDMGLKVGHATRSVDESIRQARGDMTIRTAILETRYLAGDRPLYDELVERFDTEVVQGTAAEFVAAKLAEREERHRRGGQSRYLVEPNVKDGKGGLRDLHTLFWIAKYVYRVRETAELVERGVFDAHEYRTFRRCADFLWSVRCNLHFVSGRPEERLSFDLQREIAVRLGYTSHPGMQDVERFMKHYFLVAKEVGNLTAILCAKLEDQQAKPAPVLSRVISRLKTGNSWRRVPESDDFIVDNNRINLAAPDVFKHDPVNLIRIFRLAQKNNLAFHPDAMRAVTRSLNLINTELRDNPDANRLFMEILTSNDAETVLRRMNETGVLGHFIRAFGRIVSMMQFNMYHHYTVDEHLIRCIGFLQEIERGGIDEFALASDLMRKIRPEHRAVIYISVLLHDVAKGRPEDHSIAGAKVARRLCPRLGFNNADTELVAWLIEEHLTMSTVAQSRDLSDRRTIEKFAAVVQSVEQMKLLTILTTADIRGVGPGVWNGWKAQLLRTLYYETEPVLTGGFSEVNRAKRITAAQAEFRNAFTDWPEDELNTYIGRHYPAYWLKVELPRKIRHARFVRASEDAGHKLAINVGFDPARGVTELTIFAMDHPWLLSIIAGACASAGANIVDAQIYTTTDGRALDTIAISREYERDEDEGRRATRIGETIEQVLEGKLRLPDAVARRTTRGKQHKAFSVEPEVSINNQWSELYTVIEVSGLDRPGLLYELTTAISKLNLNIASAHVATFGERARDVFYVTDLLGAQINAPTRQAAIKSALLHLLASDDTAAQPAA
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: RBSD_BACC0
Sequence: MKKHGVLNSEIAAVLASLGHTDTIVIADCGLPIPDGVKRIDLAVEIGKPSFLDVLQVVADDMAIEKVTLAEEVINNNAEVNKEIELKLIEPAFEYVCHEQFKEHTKKAKAIIRTGEATPYANVILHAGVIF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_CHLSY
Sequence: MIAVINYGAGNLPNVVRALQRVGATLTVTDNPEVIRSAQAVVLPGVGATADTMASLRHLGIAEVLPAVIAASTPFLGICVGMQVLLSESEEFGLHSCLDIIPGTVRRLPEHAGKIPQIGWNQLQISPTFRNHPLFADIPDGADVYFVHSYYCAVADEAIIAARTDYGIPFPSVIIRDHLAAVQFHPEKSGDYGLRLLANFVRWSEAVQPKGV
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1975_LEPCP
Sequence: MIKGQLAGLMKQAQAMQDNLKKAQDELANVEVEGQSGAGLVKVVMTCKHDVKRLSIDPSLLADDKDMLEDLVAAAFNDAVRRAEAVSQEKMGKLTAGMPLPPGMKFPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Lcho_1975.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PAX5_MOUSE
Sequence: MDLEKNYPTPRTIRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSPAARGAAPPAAATAYDRH
What is the function of this protein?
Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:9042861).  Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:16546096).  In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:9042861, PubMed:16546096).  Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (By similarity).
What are the official names of this protein?
Paired box protein Pax-5, B-cell-specific transcription factor, BSAP.
What are the subcellular locations of this protein?
Nucleus.
Protein: COBD_CLOTE
Sequence: MGLIDIIVAVLLDFAIGDPYWFPHPVIYIGKLISYLEEVGRKHFKSNKGLKTLGGLVVLTIAITSFGIPFLILWMVKDSFWIFHFLNIILIWTTLAAKSLKVEGKRVYYALKNEDIQEAREKLSYIVGRDTRNLTEEEIIRADIETIMENTADGVIAPLFYAMIGGAPFAMMYKGINTMDSMLGYMNDKYIHLGFFPAKVDDVFNFIPARISGVLICLSAPIVKGNIIRSFKVMLRDRKNHKSPNCAYPEGAGAGVMGIQLGGTNVYFGKAVYKPTIGDRIKDLHHELINDSVKLMYASETLMVIIYALTVTSYNLR
What is the function of this protein?
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
What are the official names of this protein?
Cobalamin biosynthesis protein CobD.
What is the protein family that this protein belongs to?
Belongs to the CobD/CbiB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DDL_STRPS
Sequence: MKQTIILLYGGRSAEREVSVLSAESVMRAVDYDRFTVKTFFISQSGDFIKTQEFSHDPGQEDRLMTNETIDWDKKVAPSAIYEEGAVVFPVLHGPMGEDGSVQGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVAIVEGDDVTAKIAEVEEKLAYPVFTKPSNMGSSVGISKSENQEELRQALELAFRYDSRVLVEQGVNAREIEVGLLGNYDVKSTLPGEVVKDVAFYDYDAKYIDNKITMDIPAKISDDVVAVMRQNAETAFRAIGGLGLSRCDFFYTDKGEIFLNELNTMPGFTQWSMYPLLWDNMGISYPELIERLVDLAKESFDKREAHLI
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_EHRCJ
Sequence: MAKRIGLFLEKVGHTAIFDNEGKRIPVTLLHLRDSFIISTKTKDINGYNAVVLGVESSVNIKKPQLKILEKSNITAKCRIFESRVDNLDGIVKGAKISITHFVENQYIDVTGYSLGKGFAGVMKRHNFKGLKASHGVSIAHRSQGSTGQCQDPGRVYKGKKMAGHLGSSKVTVQNLKVILVDQERSLLVVKGNNIPGAKGSYVFVKDAVKKSVPKNSFPVCTEDLKLDNIV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: COX3_MAIZE
Sequence: MIESQRHSYHLVDPSPWPISGSLGALATTVGGVMYMHSFQGGATLLSLGLIFLLYTMFVWWRDVLRESTLEGHHTKAVQLGPRYGSILFIVSEVMSFFLFFWASSHSSLAPTVEIGGIWPPKGIGVLDPWEIPLLNTPILPSSGAAVTWAHHAILAGKEKRAVYALVATVLLALVSTGFQGMEYYQAPSTISDSIYGSTFLLATGFHGFHVIIGTLFLIVCGIRQYLGHLTKKHHVGFEAAAWYWHFVDVVRLFPFVSIYWWGGT
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TGT_RICCN
Sequence: MSKFSFNIHHQHKKARSGIIVTAHGEMRTPAFMPVGTRGTVKAMLPESVAETGADILLGNTYHLMLQPTAERIVQLGGLHKFMNWDKPILTDSGGFQVMSLSKLCKITEEGVSFSSHINGDKYMLTPERSTEIQYLLGSTITMAFDECTPYPATFEEAKTSMQLTTRWANRSRNAFVKREGYAQFGIIQGSVYEELREQSAKDLVELDFEGYAIGGLAVGEGQELMFKVLDYAPEFLPQNKPRYLMGVGKPVDIIGAVSRGIDMFDCVIPTRSGRNGQAFTKYGTVNIRNSKYADDNKPLEHDCLCPACRNYSKAYLHHLVRIGEILGSMLMTWHNLTYFQNLMSRIRAYIKLGKDFDFDS
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RL23_METMA
Sequence: MSSINYPFVTEKAMMLLDENKLQFIVDTRSNKKQIVEDVEKLYGFKVKAVRTMTTMKGTKKAVLAFEEPEAAHEIATRIGLM
What is the function of this protein?
Binds to 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: KCY_ACIBS
Sequence: MTVQIITIDGPSGSGKGTLAAKLAAYYQFHLLDSGALYRLLGLSLHKHDLLEKLDSHLDECVNYARQLNIKFETSAEGTLVFLDGEDVTQTIRTERVGEYASKVAAIPELRQALFERQRAFAQTPGLVADGRDMATSIFPEANAKIYLTASAESRAERRVKQLQGMGLDAKINDILANIQARDKRDMEREVAPLKPAGDAYIIDSSELTIDQVFKLMVDYVNSRTVSN
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMK2B_MOUSE
Sequence: MENFHAQYVMLETIGHGGCSKVMLARHRLTGSHVAVKMIRKSECWCNPVMSEVELLMMADHPNIISLLQVIETKKKVYLIMELCEGKSLYQHIRNAGYLQEDEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLGTQVKPGQKLNLFCGTYPFSAPEVLLSRPYDGPKIDVWTLGVVLYFMVTGKVPFDAASIQKLVRQILAGKYFVPSRLSVELRDLISLLMTANPKLRPTVAEVMVHPWVTEGSGVFPDPCEEQMPLKPNPAIVKAMGYIGFQAQDIEDSLRQRKFNETMASYCLLKKQILKECDRPIRAQPMNPSVTPFPSLVDTSTFHLGLRRRETEPTSLRLSANRQMSVCGRSTSKKRDRRFSWPSVSGRPLHTTHTMDHTHTRTRSVPCIYSMFCTIQPNSSDDSTEGHTSASAEDKPVRSRGWPRGIKGWTRKIGNVMRKLCCCIPSKETSHVGHSRVSPKK
What is the function of this protein?
May play a role in sperm motility, especially in the regulation of flagellar function.
What are the official names of this protein?
Sperm motility kinase 2B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily.
Protein: 2ABA_ARATH
Sequence: MNGGDEVVAASADPSLPLEWRFSQVFGERSAGEEVQEVDIISAIEFDNSGNHLATGDRGGRVVLFERTDTNNSSGTRRELEEADYPLRHPEFRYKTEFQSHDPEFDYLKSLEIEEKINKIRWCQTANGALFLLSTNDKTIKFWKVQDKKIKKICDMNSDPSRTVGNGTVASSSNSNITNSCLVNGGVSEVNNSLCNDFSLPAGGISSLRLPVVVTSHESSPVARCRRVYAHAHDYHINSISNNSDGETFISADDLRINLWNLEISNQSFNIVDVKPAKMEDLSEVITSAEFHPTHCNMLAYSSSKGSIRLIDLRQSALCDSHSKLFEEPEQAGPKSFFTEIIASVSDIKFAKEGRYLLSRDYMTLKLWDINMDAGPVATFQVHEYLKPKLCDLYENDSIFDKFECCISGNGLRAATGSYSNLFRVFGVAPGSTETATLEASRNPMRRHVPIPSRPSRALSSITRVVSRGSESPGVDGNTNALDYTTKLLHLAWHPNENSIACAAANSLYMYYA
What is the function of this protein?
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
What are the official names of this protein?
Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, AtB alpha, PP2A, subunit B, alpha isoform.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B family.
Protein: RL23_HELMI
Sequence: MRSPYDVLKKPVITERSMDLAQENKYTFVVEPKANKIEIKHAVEQLFNVKVLDVHTMNVKGKPKRMGKYAGRTADKKKAIVTLKEGDKIEIFEGV
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: MGN_MOUSE
Sequence: MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome.  Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation.  The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex.  Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly.
What are the official names of this protein?
Protein mago nashi homolog.
What is the protein family that this protein belongs to?
Belongs to the mago nashi family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Detected in granule-like structures in the dendroplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
Protein: ACEK_BURO0
Sequence: MNHFPKLLSSQIGFDVAQTMLEYFDRHYRIFREAAVDAKTLFERGDWHGLQRLARERITSYDERVKECVEVLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGLAVTLERIVTNFQLDPPFEDLTRDIGCVMQAIDDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRIINADRVLPFAVPIRHVRPGVLALDTVLLRRDLLQIIFSFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDHALVRELEKEVPSLLEYEDDKLVIKHLYIERRMTPLNLYLQNGSDADVEHGVKEYGNAVKELMKANIFPGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRVRSVFMKHHADFFDPALWQASKDKLMQGELPDFYPYDAALRFSVRYPARFGATGENDGAGDAQRAA
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
Protein: VATD_METS3
Sequence: MAQDIIDGINPTRMELLSLKNRTKLAVKGHGLLKEKRDALIKEFFDILDRVKGVREAAERSLKEANEALLEAQIAMGDLAVRKASLSVKESIDVDIKSRSVMGVSVPVTNVKMEERSIIDRGYSFSDTTIQLDEAAKKFEESIKFLIELGEVEKTIFLLAEEIEATKRRVNALEHIMIPRFENTEKYIDMRLQEMERENFVRLKMIRSTIEKKDNEAKEAAIEEEAAEVEA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.