PharMolix/UniProtQA huggingface dataset:
Protein: UVRB_TROW8
Sequence: MYKNLHPKYFRLAAEYDPSGDQPKAIGELSDRIESGETDIVLLGATGTGKSATIAWLIEKLARPTLIIAHNKTLAAQLANEFRKFFPDNAVEYFVSYYDYYQPEAYVPKTDTFIEKDASVNSEVERLRHRATTSLLTRRDVIVVATVSCIYGLGAPSEYLKAGFRLEVGQKISQRVLLERFTQLQYNRNDVGFERGNFRVRGDTIEIIPVYEEYTVRIEMWGDEIERVLCLHPVTGNLLSEQRGVLIFPASHYVTSSENLKRAIVDIRKELQQRLRYFKRNNSLLEAQRLETRTEYDIELMEQLGFCSGIENYSRHIDGRAPGEPPFCLLDYFDDDFLTVIDESHVTVPQIGSMHAGDFSRKKALVENGFRLPSAIDNRPLCFDEFRQRVGQVIYLSATPGKYELSKSDGVVEQIIRPTGLVDPKITVKPIKGQIDDLLEEIRKRKLLSERVLVTTLTKRMAEELTDFLSEAGVNVSYLHSDIDTLHRVELLTSLRMGRIDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTTSFIQTIGRAARHVSGEVHMYADNMTESMQKSIDETNRRRRIQQDYNRKMGVTPVPIKKTVSDITEVLSRPSRKIDCTILDSLPDPKIDGKQIKSHIKSLEAKMYMAAESLMFEEAAELRDEIQSLKEKFLKPRGSGGKIRQ
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREE_HELP2
Sequence: MIIERLVGNLRDLNPLDFNVDYVDLEWFETRKKIARFKTRQGKDIAIRLKDAPKLGLSQGDILFKEEKEIIAVNILDSEVIHIQAKSVAEVAKICYEIGNRHAALYYGESQFEFKTPFEKPTLALLEKLGVQNRVLSSKLDSKERLTVSMPHSEPNFKVSLASDFKVVMK
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOIL1_MOUSE
Sequence: MDEKTKKAEEMALSLARAVAGGDEQAAIKYATWLAEQRVPLRVQVKPEVSPTQDIRLCVSVEDAYMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPSLQQWVVGQRLARDQETLHSHGIRRNGDGAYLYLLSARNTSLNPQELQRQRQLRMLEDLGFKDLTLQSRGPLEPVLPKPRTNQEPGQPDAAPESPPVGWQCPGCTFINKPTRPGCEMCCRARPETYQIPASYQPDEEERARLAGEEEALRQYQQRKQQQQEGNYLQHVQLEQRSLVLNTEPTECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVACPFIDSTYSCPGKLLEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEFTCPVCTRVNCLLCKAIHEHMNCREYQDDLALRAQNDVAARQTTEMLKVMLQQGEAMHCPQCRIVVQKKDGCDWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH
What is the function of this protein?
E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates.  Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination.  Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome.  Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation.  LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways.  Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation.  LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex.  The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria.  LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin.  The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation.  Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.  Binds polyubiquitin of different linkage types.
What are the official names of this protein?
RanBP-type and C3HC4-type zinc finger-containing protein 1, Heme-oxidized IRP2 ubiquitin ligase 1 homolog, HOIL-1, RING-type E3 ubiquitin transferase HOIL-1, UbcM4-interacting protein 28, Ubiquitin-conjugating enzyme 7-interacting protein 3.
What is the protein family that this protein belongs to?
Belongs to the RBR family.
Protein: RL10_CAMC1
Sequence: MTRNEKTEVVAKLESEFKTAEAIVVCDYRGLSVKKLEVLRNSAKEQNVKVQVIKNTLANIALKNSDKVGMELKDTNIYLWSEDQLAVTKVAAKFEESNSDLFKIKTAYIDGEVASVDKVKALSKMPSRDELIAMLLQVWNAPIQNFTIGLNALKEKKEQSA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: TGT_ACIBC
Sequence: MKFEKLGQSGRARRGRLTLEHGVVETPVFMPVGTYGTVKGMLPRDIEDIQAQIILGNTFHLYLRPGLEVIKQHGGLHDFIKWNKPILTDSGGFQVFSLGAMRKIKEEGVTFRSPIDGSKVFLSPEISMEIQHVLNSDIVMIFDECTPYPATHEEAQKSLQLSLRWAKRCKTHHHDELKNKNALFGIIQGGMYEDLRDESLNGLLEIGFDGYAIGGLSVGEPKEEMIKVLDYLPNKMPHDKPRYLMGVGKPEDIVEAVRRGVDMFDCVMPTRNARNGHYFVTDGLVRIRNSKYRHDQGPLDPHCDCYTCKNFTRAYLFHLEKCGEMLASMLGTIHNLRYYQRLTEGMRDALDNGTFDEFVQDFYARRGLEVPPCPVDE
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PABPB_XENLA
Sequence: MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIDKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKEWFGQYGAALSVKVMTDDHGKSRGFGFVSFERHEDAQKAVDDMNGKDLNGKAIFVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFTPFGSITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRVPNPVINPYQPPPSSYFMAAIPPAQNRAAYYPPGQIAQLRPSPRWTAQGARPHPFQNMAGAIRPSAPRPPTFSTMRPTSQVPRVMSAQRVANTSTQTMGPRPTTAAAAATSAVRTVPQYKYAAGVRNTQQHLNTQPQVAMQQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKVVSATGVPTA
What is the function of this protein?
Binds the poly(A) tail of mRNA.  Prevents mRNA deadenylation and confers poly(A) stability.  Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity).
What are the official names of this protein?
Polyadenylate-binding protein 1-B, PABP-1-B, Poly(A)-binding protein 1-B, xPABP1-B, Cytoplasmic poly(A)-binding protein 1-B.
What is the protein family that this protein belongs to?
Belongs to the polyadenylate-binding protein type-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with polysomes.
Protein: FABH_STRA1
Sequence: MVFAKISQLAHYAPSQIIKNEDLSLIMDTSDDWISSRTGIKQRHISKNETTADLANKVAEQLIEKSGYSASQIDFIIVATMTPDSMMPSTAARVQAHIGASNAFAFDLSAACSGFVFALSTAEKLISSGSYQKGLVIGAETVSKVLDWTDRGTAVLFGDGAGGVLLEASKEKHFLAESLNTDGSRQGLQSSQVGLNSPFSDEVLDDKFLKMDGRAIFDFAIKEVSKSINHLIETSYLEKEDIDYLFLHQANRRILDKMSRKIDIARDKFPENMMDYGNTSAASIPILLSESYENGLLKLDGNQTILLSGFGGGLTWGSLIVKI
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_METKA
Sequence: MRVALRVAYDGSRYHGFQYQPDVPTIEGALRKALSELGLELVGYASRTDAGAHARYQVVVVEGDPELAQPDPINARLPKDIRVIAKTEVHEEFDPRRDALRKEYRYFLGPLNRPEAAARAARKLEGKHDFSAFRREDGRNPIITVERCELVEITPNAYVLRVVAPRFLWEMVRRIAGFVWEVGHGLREEGDAEALLSGKFEPSKKPRCLPAEGLILWHIEYDEVRFERTKAWFEDHKVIQLGGRLLLRLPEGAESC
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: APOC4_BOVIN
Sequence: MSFPGCRPQALASLCFCVLVLACVVACQQEEPEGTLSPQPAPARSSWSLVPGKVKEWVEPLVNRTREKWKWFWGPTAFRGFMETYYDDHLKDLGSRARAWLRSSKDNLLNKAHSLCPQLLCRPSDQN
What is the function of this protein?
May participate in lipoprotein metabolism.
What are the official names of this protein?
Apolipoprotein C-IV, Apo-CIV, ApoC-IV, Apolipoprotein C4.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C4 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVD_HAHCH
Sequence: MPEYRSSTTTKGRNMAGARALWRATGMKTEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLVCREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMANAHCADALVCISNCDKITPGMLMAALRLNIPAIFVSGGPMEAGKTKLSEHKLDLVDAMVIAADSSASDELTEEYERSACPTCGSCSGMFTANSMNCLTEAIGLSLPGNGTTLATHSDREQLFLTAARRIVDLTKRYYQDEDTSVLPRSIASFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVDFSMTHIDHLSRKVGQFCKVAPNTPKYHIEDVHRAGGIMAILGELDRAGLLHTDVPTVHSDTMKDALDAWDVMRNNDPELHKFFKAGPAGIPTQQAFSQSTRWSSLDLDRENGCIRSAEHAFSKEGGLAVLYGNIAEDGCIVKTAGVDESILLFKGKARIFESQDDAVKGILNDQVKEGDVVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLIEEGDEIIIDIPNRGINVSLTPEQLKARRQAMEAKGADAWKPAQPRPRKVTTALKAYALLATSADKGAVRDKELLK
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: MIAB_STAAC
Sequence: MNEEQRKASSVDVLAERDKKAEKDYSKYFEHVYQPPNLKEAKKRGKQEVRYNRDFQIDEKYRGMGNERTFLIKTYGCQMNAHDTEVIAGILEALGYQATTDINTADVILINTCAIRENAENKVFSEIGNLKHLKKERPDILIGVCGCMSQEESVVNKILKSYQNVDMIFGTHNIHHLPEILEEAYLSKAMVVEVWSKEGDVIENLPKVREGNIKAWVNIMYGCDKFCTYCIVPFTRGKERSRRPEDIIDEVRELAREGYKEITLLGQNVNSYGKDLQDIEYDLGDLLQAISKIAIPRVRFTTSHPWDFTDHMIDVISEGGNIVPHIHLPVQSGNNAVLKIMGRKYTRESYLDLVKRIKDRIPNVALTTDIIVGYPNESEEQFEETLTLYDEVGFEHAYTYLYSQRDGTPAAKMKDNVPLNVKKERLQRLNKKVGHYSQIAMSKYEGQTVTVLCEGSSKKDDQVLAGYTDKNKLVNFKAPKEMIGKLVEVRIDEAKQYSLNGSFIKEVEPEMVIQ
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SVIP_PONAB
Sequence: MGLCFPCPGESAPPTPDLEEKRAKLAEAAERRQKEAASRGILDVQSVQEKRKKKEKIEKQIATSGPPPEGGLRWTVS
What are the official names of this protein?
Small VCP/p97-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the SVIP family.
Protein: YPEV_LACDL
Sequence: MLYGDRSIENTDGTIRSLSNRHVQMIAIGGTIGTGLFLGAGTTISATGPSVIFIYAIMGLFFFFLLRALGEMFYFDSNSHTFVSFITRYLGEAAGRFAGWTYWIGILFACMAELTAVSTYVQYWLPGLPAWLIEVSVLGLLTLLNLTAAKLFGETEFWFAMIKIIAIISLVVTGI
What are the official names of this protein?
Uncharacterized transporter in pepV 3'region, ORF2.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MSRP_ECO27
Sequence: MKKNQFLKESDVTAESVFFMKRRQVLKALGISAAALSLPHAAHADLLSWFKGNDRPPAPAGKPLEFSKPAAWQNNLPLTPADKVSGYNNFYEFGLDKADPAANAGSLKTDPWTLKISGEVAKPLTLDHDDLTRRFPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNAKYVAFETIYAPEQMPGQQDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTSERPPTTWNLAAPDEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYADQVASLYRGLDLRENF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: PDXS_ROSS1
Sequence: MDKSTWTTKVGLAQMLKGGVIMDVVTPEQARIAEEAGAVAVMALERVPADIRAQGGVARMSDPELILAIKEAVTIPVMAKARIGHFVEAQILEALGIDYIDESEVLTPADEEHHINKHKFRVPFVCGCRNLGEALRRVAEGAAMLRTKGEAGTGNVVEAVRHARAVYSEIRRLQSMDEDELFTYAKNIQAPYELVRQVAETGRLPVVNFAAGGIATPADAALLMQLGVDGVFVGSGIFKSGDPARRARAIVAATTHYNEPEIIAEVSRGLGEAMVGIEISKIPHDQLMAERGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: KCNN_DROME
Sequence: MSIQKLNDTTNSGYVSSEETDSLLVSSSNPSKGGGRTALLRQVKSNSTNGPTTGASTSSSGSVSGGGGGSGSGGGSASGSAAGASKPTLMRQDRTSTYLTSPQQSQHARMGSEESMRGGASGAAGHDEDVEQGLVRSSIVPDIEVHEEDQEQHSQQLNATTMATMTNNQQQQQPTISIMNLSLKPGDSHSHSSSPGSHPNLGTSSYQNLASSIPPSVPSRCRACRNCSRRASTTPTTLIDRSASRDSVKSAFQQGNLSGSMAICISNSALPQQQQLQQQYHLQQQQQQHYQLQQHHLHQQQLQQSQQQVPPVLITSSPTNGSRIIRQSSQPESSSTAICCGPHSACVGHAHSHSHTVPNVSLKQLRESSGDGIAGIAADSLRINGGMRPFKQLRKPASTLSIPGSMKTPSIANREQISSGCNEEAAEALVGIHSDYPRYEMYMEERALTGGNTSRKPSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGMFGIIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQLFMIDNCADDWRIAMTWQRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFHDEEHANLLNSMWLTAITFLCVGYGDIVPNTYCGRGITLTCGMVGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPDLLSRCLTQHQERIEQRRNFLHPDTAAVAPIQAPTPQSMFNAAPMLFPHSS
What is the function of this protein?
Forms a voltage-independent potassium channel activated by intracellular calcium.  Activation is followed by membrane hyperpolarization.  Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.  The channel is blocked by apamin (By similarity).
What are the official names of this protein?
Small conductance calcium-activated potassium channel protein, Protein SK, dSK.
What is the protein family that this protein belongs to?
Belongs to the potassium channel KCNN family. SK subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IQGA2_HUMAN
Sequence: MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDKDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK
What is the function of this protein?
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity.  Associates with calmodulin.
What are the official names of this protein?
Ras GTPase-activating-like protein IQGAP2.
Protein: COAT_MWLMV
Sequence: MATQLTTRARRATRVSRKGSQPASKQDVKQVVKSILGQSLEHKRANLLLPPTVVNTTGNIYCLTQFVIEGDGISQRTGRVINLEQMVLRYRRTLDTTSANSGFLRYIVFLDTQNQGTLPAITDVLSSLDVSSGYEVLNAQQNRFKFLLDEVESLCASATNLSKASTLTFNQKVQVHYGGAADAATSNRRNAVFFLELSDKVATGPQTRLGVQLKFTDA
What are the official names of this protein?
Coat protein.
What are the subcellular locations of this protein?
Virion.
Protein: TIPA_PHAVU
Sequence: MATRRYSFGRTDEATHPDSMRASLAEFASTFIFVFAGEGSGLALVKIYQDSAFSAGELLALALAHAFALFAAVSASMHVSGGHVNPAVSFGALIGGRISVIRAVYYWIAQLLGSIVAALVLRLVTNNMRPSGFHVSPGVGVGHMFILEVVMTFGLMYTVYGTAIDPKRGAVSYIAPLAIGLIVGANILVGGPFDGACMNPALAFGPSLVGWQWHQHWIFWVGPLLGAALAALVYEYAVIPIEPPPHHHQPLATEDY
What is the function of this protein?
Channel protein in tonoplast.  These proteins may allow the diffusion of amino acids and/or peptides from the vacuolar compartment to the cytoplasm.
What are the official names of this protein?
Probable aquaporin TIP-type alpha, Alpha TIP, Tonoplast intrinsic protein alpha.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. TIP (TC 1.A.8.10) subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein: ILVD_FRATT
Sequence: MKKVLNKYSRRLTEDKSQGASQAMLYGTEMNDADMHKPQIGIGSVWYEGNTCNMHLNQLAQFVKDSVEKENLKGMRFNTIGVSDGISMGTDGMSYSLQSRDLIADSIETVMSAHWYDGLVSIPGCDKNMPGCMMALGRLNRPGFVIYGGTIQAGVMRGKPIDIVTAFQSYGACLSGQITEQERQETIKKACPGAGACGGMYTANTMACAIEALGMSLPFSSSTSATSVEKVQECDKAGETIKNLLELDIKPRDIMTRKAFENAMVLITVMGGSTNAVLHLLAMASSVDVDLSIDDFQEIANKTPVLADFKPSGKYVKANLHAIGGTPAVMKMLLKAGMLHGDCLTVTGKTLAENLENVADLPEDNTIIHKLDNPIKKTGHLQILKGNVAPEGSVAKITGKEGEIFEGVANVFDSEEEMVAAVETGKVKKGDVIVIRYEGPKGGPGMPEMLKPTSLIMGAGLGQDVALITDGRFSGGSHGFIVGHITPEAYEGGMIALLENGDKITIDAINNVINVDLSDQEIAQRKSKWRASKQKASRGTLKKYIKTVSSA
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: IHFB_BORPA
Sequence: MTKSELIAALAARYPQLAARDTDYAVKTMLDAMTQALASGQRIEIRGFGSFSLSQRSPRIGRNPKSGEQVLVPGKQVPHFKAGKELRERVDLVGNDQGDDSSNGSSDPLQSVMDMHAMH
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: EEN_ARATH
Sequence: MERELMEADIVVASRLSFKKKQAYEKYPKAQSSSRRWKHLKQILQAENFPDLPPDLPTYVNIESPPSTQPCKRLCDITGYEAPYVDPRTNLRYANAHVFQTVRSLSSDQVHQYLSIRNAAVVLK
What is the function of this protein?
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity).  Together with REF6/EIN6, involved in the epigenetic chromatin-dependent regulatory mechanism that monitors the expression of the essential multifunctional plant stress regulator EIN2 via H3K27me3 repressive histone demethylation and histone variant H2A. Z eviction, thus modulating responses to ethylene (ET), especially during embryogenesis (PubMed:31418686).  The INO80 complex controls ethylene-induced H2A. Z eviction dynamics (PubMed:31418686).
What are the official names of this protein?
Protein EIN6 ENHANCER, Protein ENHANCER OF ETHYLENE INSENSITIVITY 6.
What is the protein family that this protein belongs to?
Belongs to the IES6 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.