PharMolix/UniProtQA huggingface dataset:
Protein: L_HIRRV
Sequence: MDFFDLDIEIKQERLPAECSLNSPLNISLSSQLTDRMTPQNENIRRQRERIRTHTKTHSRIKHLSKLDNDSTRLHARLTEDLIKLQHLEVDSPVFDNWALLTSYYAALDYTLPERASFDWGQAAPYWNLYTQLRTILLQSQKIRKKDRGVREIYSCGPLRLEFVEGTVLYFTDKQSGGEFTKSGELPSITPYADFLAWVKIISQRAQAVLMAVILRVTDKGLSPLPESLLSVYQTVDDILKRAGQPAIDLLKLWEPLVITKLGELLGDRFGLEEDFRLTIRGEATRLAKKLAITNGLNRLMTVLDSQTEAQPLFQFFGLFKHFAYPRVFSRDTIQAIQEVSDRPSSISAAEFLHDQCEIRKEFYIRYLKAYHRAPGLDLSALSPSSFLRESLEHGKIPNEKSPHYSNKEWYFIKFTKSIEWPISDTLSTFLSDKAITRDRAAWIEEGHSGRDMSEKRLLLKFIKENFSSVAEIVAAADAIYNNEGDRLIALKVKEMELKIKGRGFGLMTFMPRLLQVLRESIAKKTSKLFPEITMTSSDLDMKKRKFMLSKRSDDRRGFIHINKSLDINKFCTSQRQFNSSAVFSSLDEMMGTFPLFSRVHEIFEKTWIVDGSASDPPDLSHFTRILEECRLHGIEAPHVWADGVFSGLKGGIEGLCQYVWTICLLLRVERVMQKTKLTHYILAQGDNVIITIIVPVEIHRDGIISDQESRRLLTLSRNIDLSLESELEKSGLTLKIEETLTSENISIYGKDLHCPQHLTLALKKAASAAIISSEQYQDIPTFLSGLGTSLESLSECVNSKTGAHLFGVLMGVAGWKDLATHQTWRGWRYPYHKAPLSGRVRASDMKIGKGEAVELTIPVMSPRQQGKETLRELLANSLLGSALGMLAFPTPIDLEKRGVGDYITHRLAIARKALLSEKLDPHIEKRVRSACNLPLSSRVDLSKLFDSPFSLNLATEEDATAVIKRQAKKTLRLQEIGNDKLRAQIGNMDKGIAALDADLAGAETINPRLNHMIRDITDEKESEMFVTKFASARTMRTLAMGDSSEVPIVVLLEKKSQQKELYTIWRARRPHATMWKCSTVLAKGLRDISWGKTIVGVTSPSPIEAMETTHIDPTDWEDSRSRETLSINYYLSRAGIDEQTAKLTRGSLVPYYGTQTKPLIAKAYLELKGNPRTNKALLLLSVRESLVKTGSNLDELIMQLCSHALDIDAASLPALRAQEEATAGEGLRGGIKESMSPVGPDNFYTNITHKVFNRKWVTPYHVNIADFIIQGLIETRKHLILNEKMDGLLPLSSVKCTACFRKKEREFFDIPEGPTWKNDSTTSDPAYTYFTTWCDLPRVSTLPTMDQQSATRLLGRGLSLNRPTAGEIITKFYSMSMESQRLLHPVDLLLGYGEGVVFGYIRSQHIHHGALFQTKRETLTNKLRKFILDTKTQHAKQIGYLFQDEDSLHELMAQGLCPYVPRSIPLTITELTNACAITTIRATEVILSAGSRVALMPVQAIDETDVDNSRLAANTMQTILGDSRPMNPVYLDCDLTTNMTAWESSIELDVLKSENFHIDGLLMDLTARELPISDTPWKQRDWTCSNDPRIIAKGIKTKSLFIHQGVAEALNMTPDLLVVIGGGLGGCAVPYLQEWADVPLIFATLFDERERISEDGDLVVPPEILVRGMAPRMIERELLEAELCDVTNDGNRRLLTRLVKKNRGKGTVVLIDEIENRGAPESLLQSSLQDLVRRLDKVCTLTSIHTVRESTVEQFAQRTNSIKRDRKTVTLHWNRYNRRDQFEALVIVKGEETRSDYHVSTATAAQAFRKIDEQLEVEGRLSATRWSLPTLPAREKEILFGYVSSVFLKTNLVLSADDMDRETLLETIEDTAPGLISWKEKLEHRDHAFRSDIDEKGITQDKVFNLICLAWVITGLRYGIWETDAQSIITKTVYITRGPKLCPLGEKPKRVFASFKLQSDKRVEDAKGFLSALLHLEGFFPLGRQ
What is the function of this protein?
RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA.  The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N).  The replicase mode is dependent on intracellular N protein concentration.  In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
What are the official names of this protein?
RNA-directed RNA polymerase L, Protein L, Large structural protein, Replicase, Transcriptase.
What is the protein family that this protein belongs to?
Belongs to the rhabdoviridae protein L family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=L and P are packaged asymmetrically towards the blunt end of the virus.
Protein: RS24_SACS2
Sequence: MESQAKVKISDKAEGIIERDMQNSVIGRREISLKVYHMGSGTPSRKDIIKAIIQALGSQENLVVVRKISTSYGAGISNVKLHIYKSREILEKVEPKYLLDRDAGTKQKKGGSKGGQGAKG
What are the official names of this protein?
30S ribosomal protein S24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: RL15_PARDP
Sequence: MKLHELHDNPGANRKKKRVARGPGSGKGKTAGRGIKGQTSRSGVALNGYEGGQMPLYRRLPKRGFSKPNRLEFAVVNLGQLQAFVDAGKLDAKADVTEDALVAAGVIRRKLDGVRVLAKGEIKAALNLSVAGASKAAVEAIEKAGGKITVSRPAKEAAAAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ECTC_DESAL
Sequence: MLVRQLDDILGTDADVKGETGTWASRRLLLKKDGMGFSLHDTIIYPGTETHLWYKNHLEAVYCIHGKGEIELVPSGELIPIRPGTMYALDKHDEHLLRASEELRLVCVFNPPLTGREDHDEDGAYPVLDD
What is the function of this protein?
Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.
What are the official names of this protein?
L-ectoine synthase, N-acetyldiaminobutyrate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the ectoine synthase family.
Protein: RAPA_HAEI8
Sequence: MPFAIGQRWLSESENALGLGVITALDQRTVTIYFPAADETRIYAAAQAPLSRIVFSKGETLSHQAGWQGEILDVQNMNGLLFYLVKTPQDEDVIVQERDISPIISFSQAKDRLFSAQIDRSSHFALRYRTLCHQQAQFKSPLRGLRGTRAGLIPHQLHIAAEVGNRVNPRVLLADEVGLGKTIEAGMILQNQLFAEKVQRVLIIVPETLQHQWLVEMLRRFNLHFSLFDEERCNDFDLDAVNPFMTESLIICSLNWLETHPNRVEQALDAQFDCLIVDEAHHLVWSESAPSAAYLLVEQLARIIPSVLLLTATPEQLGQESHFARLRLLDPERFFDYQTFVKEQKRYQPVVNAIESLLANKALSAVEKNHISDLLLEQDVEPLFKAIASNNDEEQHRARQELIQALIDRHGTGRMLFRNTRQGVKGFPHRVYHQITLSEENDKIDWLINFLKLHRDEKIFVICQTAATAIQLEQILREREAIRAAVFHEKMSIIERDRAAAYFADLENGAQVLLSSSIGSEGRNFQFAANLVLFDLPTNPDLLEQCIGRLDRIGQKRDVQIYVPCAKDSPQIRLARWYNEGLNAFEQTCPMGMALFSQFEDELEKVRSNSTALSENEFSELLKQTKTVREKLKIELEKGRDRLLELNSNGGKQAQALADQIADEDNSPELVNFALKLFDIIGVEQEDLGANSIVISPTGTMLVPDFPGLKEEGVTVTFDRELALAREEMEFLTWDHPMIRQGIDLVASGDIGKAAMALLVNKQLPAGTLLIELIYIVESQSPKGLQLNRFLPPTPIRLLLDNKGNNIGEQVAFETLHSKLKPLGKNIANQMVKMARGNIEALITRGDQLVKSLAEPIITEAKNQADQQLSAEINRLQALRAVNQNIRQSEIDILEQQRTQSLDELSKANWRLDCLRVIVTNKE
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: BP40_BPPHE
Sequence: MAIATNNSRVYASLQLKNKQDSMYLAIGKTTPWTNEDAPPAPDPTTTTLTEVIGYKKVARVSLCREYLPSDDSKYPVVSYGSRKFTLIPDEDGYKEQAWMVYVEAEITGDELPTGTFRQVGIHTDLVSKASSEKKALLPTDVTDAGILQFFENRQQQNRTSDVILKEKFIITMENKKSVKQ
What is the function of this protein?
Putative baseplate protein.
What are the official names of this protein?
Virion protein 3, Gene product 40, gp40.
What is the protein family that this protein belongs to?
Belongs to the tevenvirinae baseplate structural protein gp8 family.
What are the subcellular locations of this protein?
Virion.
Protein: TDRD7_XENTR
Sequence: MLRAVLQANKNGVPLSKLQAEYKSFTGEPIPFKDMGFHALDAYLKSIPSVVRIEVSRVGEVICYAVVCKETARIAALVAHQRSSKKKSGGQVNCQMRLKYTAPVSHFGKPKATLRQPGFTPPQEKIIRKPVPTSAWGKGNTFGSRTFEYSPPPIPQLFGIAPIQMHLPNINRPERKVTLPPRFQREVNSFLNPTPMTDSNANHTQSLKSVVPGSGQPRCDLSVIQNNLKELLNKHSNGLWLSKLPQLYKETYKQDLGGEMLKQVPSWTHICMVQKLVTMGHTEMVLYSTAIKQPSFTKNVQNHSNNQAKPNVPVDSTPSSPPLQSSGNIPKDELKQKISKVLTKYSNGLWYHALPKVFEDMFKQKLPTEVLNLDSLTDICTVDLISEEPFKAILYAKSAERANQNSNPSVNNNIPQKLQDRESPLLPEEPEMNMTPPPLVIPSEASPSVLVVELSSTNDVVIRYIGRDYSAAQEHMEDEMKDFCSKSSTAKIGFLRVGQLVAAKAEEDVWLRAQISAIEGKKVKVCYVDYGFSEIVDITKVCKLGKQFYTLPFQATKCRLAGLEAFCDDSIIIKALELKACGKILAVEILEKSEKPLVVLYDTSGDDDININAACLKELCDRSLSLQLKANSSFSNVIVTNVCSDGTLFCQLPSKGLAKLYETLQKVDSEFQSKQVTSHLYVSLPFCGKICLYHYKGKWARVEITSVHSSRALDVQFLDSGTIASVKVSELKEIPPPLLRDLISIPPQALRCCLADLPLRIGMWTPDAVLWLRNTVLNCLECSIRVVKVDEATNMVHIYLFTSNNFPDLERSINRQITNEELWKHQKDVFLNLSASTLESSRGGGAQASELSPPGLCKDHTSAVKKPDMQQSSSVPSFNMPPPLPLPRPGEHMDVFVSVACHPGHFVCQPWQELHKLEVVMEEMLLHYSTTEEKPVALEKNKLYAAKVENKWYRVLVKGILTNGLVSVYELDYGRHELVSCRKVQPLIEKFMQLPFQAITSQLAGVSCEHWSEEASIVFRNHVEKKPLVALVQTIHESTHPWDRRAVAYIVDTSLPDTDIWIHELMTEYHIQLSKPE
What is the function of this protein?
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation.  Probably required during spermatogenesis (By similarity).
What are the official names of this protein?
Tudor domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the TDRD7 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to cytoplasmic RNA granules.
Protein: GLK_ENT38
Sequence: MTKYALVGDVGGTNARLALCDIDTGEISQAKTYSGLDYPSLEAVVRVYLDEHQVGVEDGCIAIACPITGDWVAMTNHTWAFSIAEMKKNLGFAHLEIINDFTAVSMAIPMLKPEHLIQFGGAEPVEGKPIAVYGAGTGLGVSHLVHVDKRWISLPGEGGHVDFAPNSEEEGIILHELRAELGHVSAERVLSGPGLVYLYRAIVKSDNRLPENLQPKDITERALADSCTDCRRALSLFCVIMGRFGGNLALNLGTFGGVYIAGGIVPRFLEFFKASGFRGGFEDKGRFKSYVQDIPVYLIVHDNPGLLGSGAHLRQTLGQYL
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHD1A_MOUSE
Sequence: MSDLRRKGWWNVPDYFHSPLVFDMEEDKEDYIFGPHDEYLHTLEVHSNTLIQLERWFTPTGQTRVTVVGPLKARLWVMDMIRKVGSKNNLDQIKGKMMLLQIRDHPLRDRDLELHPESGSSLWITTMNDTTFVEVPHFLRFPLTVAWLFCGFVRILGIHNFADLHW
What is the function of this protein?
Has pro-apoptotic activity.
What are the official names of this protein?
KH homology domain-containing protein 1A, Nur77 downstream gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the KHDC1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Z705G_HUMAN
Sequence: MHSLKKLTFEDVAIDFTQEEWAMMDTSKRKLYRDVMLENISHLVSLGYQISKSYIILQLEQGKELWREGRVFLQDQNPNRESALKKTHMISMHPITRKDASTSMTMENSLILEDPFECNDSGEDCTRSSTITQCLLTHSGKKPYVSKQCGKSLRNLLSTEPHKQIHTKGKSYQCNLCEKAYTNCFHLRRHKMTHTGERPYACHLCRKAFTQCSHLRRHEKTHTGQRPYKCHQYGKVFIQSFNLQRHERTHLGKKCYECDKSGKAFSQSSGFRGNKIIHTGEKPHACLLCGKAFSLSSNLR
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Putative zinc finger protein 705G.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSN5_YEAS7
Sequence: MSLSNKTVKELRQLLKERYTVEDELTESIALSSMRFKPSQEPEFHALSQSSLLKTKLKQQSSTDIPSYTHVLISKLSCEKITHYAVRGGNIEIMGILMGFTLKDNIVVMDCFNLPVVGTETRVNAQLESYEYMVQYIDEMYNHNDGGDGRDYKGAKLNVVGWFHSHPGYDCWLSNIDIQTQDLNQRFQDPYVAIVVDPLKSLEDKILRMGAFRTIESKSDDNSATSYYELETIIFDSELNRALFETKLNLHCVIEDDESEQISLNRLIDSMKQYSYLMDSKNVRTRIKLATTSERVSNENKKNIDYQNRSTRSQFCLNTQRGDSTETSSFGSMFSGDNTSDVDMEDRNLTEFDSTDTSLCINGEPSIHVNRVERSSRSTDNFHNSKKRMNSNQEKCHDEGNDMLQRNVLETDYARAKNRILASKIKQYERLRFYKDTFTL
What is the function of this protein?
Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.  The CSN complex is involved in the regulation of the mating pheromone response.
What are the official names of this protein?
COP9 signalosome complex subunit 5.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Nuclear localization requires the formation of the CSN complex.
Protein: RL3_METPE
Sequence: MANIHRPRRGSLAYSPRKRAKSQVPKYHSWPARDGEPILQSFAGYKVGMTHVIMVDDHKNSPTEGKDIMVPVTIIEIPPMKVAAIRAYTADTYGKRALTEVWTEQLSTLLGRRITLPKKYSEEAGFKALSEAVAAGTVTELHALMYTQPDTLTGVPKKVPELMEVCIGGGTLEQKVEFAQSIIGNEVNLADVIGAGEYADVTAITTGKGTQGPVKRWGIMLRKRKHSRGGKKRHIGNLGPWNPHHVRWQVPQMGQMGYQQRTDFNKRILKIGENGTDITPAGGFLHYGLLRNPYVMIKGSVPGPVKRLIRIRPAVRKGEHHARVPAIEFVSTQSKQG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: LEU1_HUMAN
Sequence: MRPCIWIHVHLKPPCRLVELLPFSSALQGLSHLSLGTTLPVILPERNEEQNLQELSHNADKYQMGDCCKEEIDDSIFY
What is the function of this protein?
May act as a tumor suppressor.
What are the official names of this protein?
Leukemia-associated protein 1, Deleted in lymphocytic leukemia 1, HBV X-transactivated gene 6 protein, HBV XAg-transactivated protein 6.
Protein: AMI1_ORYSJ
Sequence: MAMAGGGRGDYGAFMERFVLPPPPSQQLPLHGLTFAIKDIFDIAGRVTGFGNPDWARTHAPAAATSPVVLAALAAGATSLGTTIMDEMAYSINGENTHYGTPTNPCAPGRVPGGSSSGSAVAVAANLVDFSLGTDTGGSVRVPAAYCGIFGLRPSHGLVSAENVIPMAQMFDTVGWFSRDLSTLSRVTKVLLPLPDDIVKQPTQVTIPMDCFQILGSLDDRTYQIINASVAKRFDSQILDNRNLGDFISDNVPSIGKFITDFSESELPSVPALSVISHVMRGLQRSQFKANHAEWVNTVKPNLGPGLRERILEAIASGDNESLEDFQAIRAEFKSALAALLKDHGILAIPTVPGPPPKVGMEAAPLENFRARAFSLLSIAGLSGFCQVSIPLGMRNGLPVSVSLVARHGADHFLLNVVEELYQTLIDEATKTWSS
What is the function of this protein?
Amidase involved in auxin biosynthesis (Probable).  Converts indole-3-acetamide (IAM) to indole-3-acetate, and phenyl-2-acetamide (PAM) to phenyl-2-acetate.  Substrate preference is PAM > IAM (PubMed:27135507).
What are the official names of this protein?
Amidase 1, OsAMI1.
What is the protein family that this protein belongs to?
Belongs to the amidase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm.
Protein: IHFA_PSEAB
Sequence: MGALTKAEIAERLYEELGLNKREAKELVELFFEEIRQALEHNEQVKLSGFGNFDLRDKRQRPGRNPKTGEEIPITARRVVTFRPGQKLKARVEAYAGTKS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: MPH6_HUMAN
Sequence: MAAERKTRLSKNLLRMKFMQRGLDSETKKQLEEEEKKIISEEHWYLDLPELKEKESFIIEEQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNAKHKAEEVEDETVELDVSDEEMARRYETLVGTIGKKFARKRDHANYEEDENGDITPIKAKKMFLKPQD
What is the function of this protein?
RNA-binding protein that associates with the RNA exosome complex.  Involved in the 3'-processing of the 7S pre-RNA to the mature 5. 8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.
What are the official names of this protein?
M-phase phosphoprotein 6.
What is the protein family that this protein belongs to?
Belongs to the MPP6 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase.
Protein: RUVA_BARBK
Sequence: MIGKLTGILDSVFEDHIILDVQGVGYVVFLSNRLLSSLPERGQAVSLFIETHVREDAIRLFGFETKVEQDWFCLLQNVRGVGAKVALAILSTLPPPQLAQAITLSDIAMISRSPGVGKMVSERIINELKNKALPSNAPHQSMPHFVSYSSETSSQAGTQHTGHQHSMDALAALTKLGFERDQATHALQEAIKAFEGETPSSALLIRHSLKLLSSHLK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: WIPI2_XENLA
Sequence: MNLASQSVDAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTTLAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPSGLCSLSINGENCYLAYPGSASIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDSIFLSASSNTETVHIFKLETIKEKPPEEPTSWTGYFGRVIMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICALATIQKISRLLVGAADGYLYIYNFDPQEGGECTLMKQHKLDGSMEPSSEILESSSHDRQVGAQTYSATVTKTYPPPSPTRHAYADDLGAVGGASEEDEMGNLRLDEDNENPPMILQTE
What is the function of this protein?
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.  Involved in an early step of the formation of preautophagosomal structures.
What are the official names of this protein?
WD repeat domain phosphoinositide-interacting protein 2, WIPI-2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DDX41_MOUSE
Sequence: MEDSEPERKRARADEATAGGSRSEDEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGATEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF
What is the function of this protein?
Probable ATP-dependent RNA helicase.  Is required during post-transcriptional gene expression.  May be involved in pre-mRNA splicing.
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX41, DEAD box protein 41.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX41 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1671_PYRHO
Sequence: MVKVKFLGHAAFYIEGSKKILIDPFLTGNPQAAARPEDFKDVDLILVTHAHGDHLGDAGEIARISGAKIVAMYDLANYISEKYKDVETIGMNYGPTEIDGVFIVQVPAWHSSSDGKYSIGNPSGYIVKLDDVTIYHAGDTYVFKDMELFAELYGPIDVALLPIGGHFTMGVREAAKAVELLKPRKVVPMHYNTWPPISADPEEFKRLVGDKAEVVILKPGEELKL
What are the official names of this protein?
UPF0173 metal-dependent hydrolase PH1671.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: PUR9_LACLM
Sequence: MSKRALISVSDKEGIVEFAKKIQELGWEIISTGGTKAVLDQEEIPNIAIDEVTGFPEMMDGRVKTLHPLIHGALLGRRDLDSHMKSMAEHHISPIDLVVVNLYPFKETLLAGGSQAEMIEKIDIGGPSMLRSAAKNHAAVTVVCDPMDYEKVEKELSADGETSLELRQQLAAKVFRHTASYDALIAQYLTEEFPVEDTKPEKLTLTYDLKQGMRYGENPQQSADFYESGLPTTYSIAQSHQLHGKELSYNNVRDADAALQIARDFDEPTVVALKHMNPCGIGTAKNIEQAWDYAYEADPVSIFGGIIVLNREVTEETAQKMSKIFLEIIIAPSYSKEALEILSKKKNIRLLTVDFSKKEQSEKEALVTGVLGGLLVQNQDVIVENPKEWTVATKVQPTDRQMEAMKFAWKAVKFVKSNGIIVTNDHQTLGVGPGQTNRVGSVKIALEATADKDALLQENAVLGSDAFFPFADNIDEIAKAGIKAIVQPGGSVRDQEVIEACDKYGIAMVFTGLRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: HEMH_PSEE4
Sequence: MTDHALLLVNLGSPASTSVADVRRYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLTRRLQAAMVEHWPHGPVEIAMRYGEPALPDVLERLAAQGVRKVTLAPLYPQFADSTVTTVVELAKQTIAERKLPLQTRILQPFYDHPDYIQALAASARPYLEQQYDHLLLSFHGLPERHLKKLDPSGNHDFQAADCCKDASAEMRAVCYRGQCLATAKAFAQKMGIPDGKWSVSFQSRLGRAKWIEPYTETRLDELGKAGVKKLLVMCPAFVADCIETLEEIGDRGKEQFIEAGGKELVLVPCLNDHPEWVRVLAGMCENA
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YVD2_VACCC
Sequence: MRSLPDIFYNFIHLQLYSLFSLLLVIISHNLGNTYPLIVRYLIQVITYNYQLFLYIIDWMVDIHGGINYSNR
What are the official names of this protein?
Uncharacterized 8.6 kDa protein.
Protein: AROA_HELPS
Sequence: MIELDINASDKSLSHRAVIFSLLAQKPCVVRNFLMGEDCLSSLEIAQNLGAKVENIAKNSFKITPPTALKEPNKILNCNNSGTSMRLYSGLLSAQKGLFVLSGDNSLNARPMKRIIEPLKAFGAKILGREDNHFAPLAILGSPLKACDYESPIASAQVKSAFILSALQAQGSSTYKENELSRNHTEIMLKSLGANIQNQNGVLTILPLEKPLEAFDFTIANDPSSAFFFALSCAITPKSRLLLKNVLLNPTRIEAFEALKKMGASIEYAIQSKDLEMIGDIYIEHAPLKAISIEQNIASLIDEIPALSIAMLFAKGKSMVKNAKDLRSKESDRIKAVVSNFKALGIECEEFEDGFCIEGLEDISQLKQRFSQKKPPLIQSFNDHRIAMSFAILTLALPLEIDNLECANISFPQFKRLLNLFKKRSFNGN
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_BIFAA
Sequence: MQGTFISFEGVDGVGKTTQVERLRAYVESQGRECVVTREPGGTALGVAIRKMLLHGVDTGDENDCADIAPRTEALLFAADRAQHVAEVILPALQRGAVVITDRYLDSSLAYQAGGRELTAAEIRNLSMWATNGLLPERTYLLDMDPAQSHARLQHAEDRMEAAGNDFQRRTRVAFLDLAEREPERFHVIDASQSIEDVWARIKADFDTVSTADGGIA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: LRC25_MOUSE
Sequence: MGSIRTRLLWLCLLMLLALLHKSGSQDLTCMVHPSRVDWTQTFNGTCLNFSGLGLSLPRSPLQASHAQVLDLSKNGLQVLPGAFFDKLEKLQTLIVTHNQLDSVDRSLALRCDLELKADCSCGLASWYALRQNCSGQQQLLCLHPATEAPRNLSTFLQVSCPPSWGPGTIGALVAGTISLAVAVSGSVLAWRLLRRRRRASEHSLSKAQMSPHDIPKPVTDFLPRYSSRRPGPKAPDSPPSRFTMDYENVFIGQPAEDCSWSAARNSPSGDSDCYMNYRSVDQDSQPVYCNLESLGR
What is the function of this protein?
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation.  Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy.  Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
What are the official names of this protein?
Leucine-rich repeat-containing protein 25, Monocyte and plasmacytoid-activated protein.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cytoplasm.
Protein: Y2206_MYCTU
Sequence: MKLLGHRKSHGHQRADASPDAGSKDGCRPDSGRTSGSDTSRGSQTTGPKGRPTPKRNQSRRHTKKGPVAPAPMTAAQARARRKSLAGPKLSREERRAEKAANRARMTERRERMMAGEEAYLLPRDRGPVRRYVRDVVDSRRNLLGLFMPSALTLLFVMFAVPQVQFYLSPAMLILLALMTIDAIILGRKVGRLVDTKFPSNTESRWRLGLYAAGRASQIRRLRAPRPQVERGGDVG
What are the official names of this protein?
Uncharacterized protein Rv2206.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PTH_XANCP
Sequence: MSALRLIVGLGNPGPEHAQTRHNAGFRFVDALAERTGARWGLDSKLFGETAKAEIAGHTVWLLKPATFMNLSGKSITAALRFWKIEPEQLLVAHDELDLAPGTARLKFDGGHGGQNGLRDTIRLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGRDDDMAIGEAVDAAIDALPLALDGNFNEAMKRLHTPKK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF120_ARATH
Sequence: MENSENVPSYDQNINFTPNLTRDQEHVIMVSALQQVISNVGGDTNSNAWEADLPPLNAGPCPLCSVTGCYGCVFPRHEAIIKKEKKHKGVRKKPSGKWAAEIWDPSLKVRRWLGTFPTAEMAAKAYNDAAAEFVGRRSARRGTKNGEEASTKKTTEKN
What is the function of this protein?
Probably acts as a transcriptional activator.  Binds to the GCC-box pathogenesis-related promoter element.  May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
What are the official names of this protein?
Ethylene-responsive transcription factor ERF120.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.