PharMolix/UniProtQA huggingface dataset:
Protein: THI42_PHYPA
Sequence: MQAAGLAAGVAFAPKISSSNVGSSSSSLAGVRMVASPKAQLRHARLPAASASMYSDAKYDLNNYKFEPIKESIVAREMTRRYMTDMITHADTDVVVVGAGSAGLSCAYELSKNPNVKVAIIEQSVSPGGGAWLGGQLFSAMVVRKPAHRFLDEIEVPYEELENYVVIKHAALFTSTIMSKLLARPNVKLFNAVAAEDLIIRGDRVSGVVTNWALVAQNHNTQSCMDPNVMEAKVVVSSCGHDGPFGATGVKRLRSIGMIESVPGMKCLDMNAAEDAIVKHTREVVPGMIVTGMEVAEIDGSPRMGPTFGAMMISGQKAAHLALKALGLPNELDGNYKPNVHPELVLASTDDETASA
What is the function of this protein?
Involved in biosynthesis of the thiamine precursor thiazole.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate.  The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.  May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
What are the official names of this protein?
Thiamine thiazole synthase 2, chloroplastic, Thiazole biosynthetic enzyme 2.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ENO_TREDE
Sequence: MSDIIYIEGREILDSRGNPTVEVEVQLSDFSYGRACVPSGASTGEYEALEMRDGDKSRYMGKGVLKAVDQVNTVIAEELDGADALDQAEIDNMLINLDGTENKSKLGANAMLGVSMAVARAAADSLGLPLYRYLGGVHAMQMPVPMANIINGGRHSDNKIDFQEYMIMPVGAPSIREGIRMTAEVFHALKDILKKEGHVTAVGDEGGFAPNIENVQALDYIMKAIEKAGYKPGKDVVIALDCASSELFDAGDRKGYKFWKSEPSKILNADEMVDLFKDWISKYPIVSIEDPLDQNDWEGYAKMTKELGNQIQIVGDDFFVTNTKRLARGIEEGACNSILIKLNQIGTVTETIDAVRMAQKAGYTAVISHRSGETEDAFIADLAVALETGQIKTGSMSRSDRIAKYNQLMRIEDELGYNARYAGMATFANLIKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: ASNA_CAEBR
Sequence: MADDQLEGSIKNILEQKSLKWVFVGGKGGVGKTTCSCSLAAQLSKVRGRVLLISTDPAHNISDAFCQKFTKTPTLVEGFTNLFAMEIDSNPSGEGVEMANIEEMLQNAAQNEGGSGNGFAMGKDFLQQFAGGLPGIDEAMSFGEMIKLIDSLDFDVVVFDTAPTGHTLRLLQFPTLLEKVFTKILSLQGMFGPMLNQFGGMFGMGGGSMNEMIEKMTTTLESVKKMNGQFKDPNCTTFVCVCIAEFLSLYETERLIQELTKQGIDTHNIIVNQLLFPDTDESGKITCRKCGSRQAIQSKYLSEIDELYEDFHVVKLPLLESEVRGGPEILKFSERMVHPEKNTNQ
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase asna-1, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: SUMO2_PIG
Sequence: MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.  Plays a role in the regulation of sumoylation status of SETX (By similarity).
What are the official names of this protein?
Small ubiquitin-related modifier 2, SUMO-2, MIF2 suppressor, SMT3 homolog 2, Sentrin-2, Ubiquitin-like protein SMT3A, Smt3A.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body.
Protein: HSPE_BRADU
Sequence: MRTYDLSPFWRSTIGFDRLLNLVNDTVDNGDTYPPYDIERTSEDQYRISLALVGFTPDDVAITAERSTLTVEGRKTDEDERDYLYRGISVRPFRRVFNLADYVQVKDATFEDGLLKIALTREMPEALKPRQIAIDVAGNDHQRSDRTQAA
What are the official names of this protein?
Small heat shock protein HspE.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: GLMM_CHLTR
Sequence: MTRDVRQLFGTDGVRGRANFEPMTVETSVLLGKAIAGVLLEKHAGKHRVVVGKDTRLSGYMFENALIAGLTSMGIETLMLGPIPTPGVAFITRAYRADAGIMISASHNPYRDNGIKIFSSDGFKIGQAVEERIEAMVASKDFGKLPDDHAVGKNKRVKDATGRYIEYAKATFPKGRTLKGLRIVLDCAHGATYRVAPSVFEELDAEVICYGCEPSGCNINAGCGALWPSTIQKAVIEHKADVGIALDGDGDRLIMVDEKGHIVDGDMLLSICASDLKRRQALSDNRVVATVMTNFGVLRYLESLGIQVTISPVGDRHVLQHMLENQAVLGGEQSGHMIFLDYNTTGDGIVSALQVLRIMIESESTLSDLTACIAKSPQALINVPVTKKVPLESLANVQGVLKEVKEVLGDSGRILLRYSGTENICRVMVEGTKKHQVDSLAKTIVDVVEAEIGAEISE
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: CAV1_DIDVI
Sequence: MSGGKYIDSEGLLYSAPIREQGNIYKPNNKSMADEMNEKQMYDAHTKEIDLVNRDPKHLNDDMVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIRSYLIEIQCISRIYSICIHTFCDPLFEAIGKIFSNVRIALQKEI
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation.  Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity).  Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).  Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.  Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity).  Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).  Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Caveolin-1.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: DAPB_WOLWR
Sequence: MKIRVGVIGCLGRMGKKILNELITNTKVEIAGAVARSGSKYIDSDIGPIIANLGIKVTSSISDVFESSDVVIDFTTKECMLDCLKAAVKFKTPLVSGTTGIEGVDLKEYAAEVPILWSANMSVGVNVLLKLVKKAAELLGNEYDVEIWEMHHNLKKDSPSGTAIELGKTIANASKVDFQSNQYLHSGSNIRKKGGIGFAVSRGGGVIGDHSVMFVNSDERIELNHKAIDRTTFARGAVQAAVWLYENKREIPGLYSMQDVI
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_SHEB9
Sequence: MSTNNSVLVLKVGGALLQCEMGMARLMDTAAAMLANGQQVLMVHGGGCLVDEQLAANGMETVKLEGLRVTPPEQMPIIAGALAGTSNKILQGAATKAGIVSVGMSLADGNTVSAKIKDERLGLVGEVTPKDGAYLKFILAQGWMPICSSIAMMDDGQMLNVNADQAATALAKLVGGKLVLLSDVSGVLDGKGQLIHSLNGKQIADLVKQGVIEKGMKVKVEAALEVAQWMGQAVQVASWRDASQLIALAKGEAVGTQIQP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUS10_XENLA
Sequence: MLLIEEKYRSVAQVLLSSGTCSRCVLRFCCVGSPANYRLPCKEVTYELQKYLSHGDPAEENDTPPSKKAKIEEDTSSNEHLGNCEDVNGSQVVRICPLCLGILQQFCEPEFIEKVFVKINSAVYELKDFVLSISLPAQLSVREHSAWLQAKQEMGKHGHSLDKTDIVQLKEAYKWIIHPLLSDQLGIQADSKSLFEVAVVFTHPETDGDCHFLATVCRDCFKPTKNKQSVFTRMAVVKALEKIKEEDFRVQFPFPPSSPETTCEVVDIQCNHSPVFVAGRYNKYSRNLPQTPWIIDGERKIESSVEELITDHLVAAFRSSSFNFSSSGREDVDVRTLGKGRPFAIELLNPHKVQFTGQEIKALQQKINTSDKIKVRDLQIVSREAVAHMKEGEEEKTKCYCALIWIEKMVRNEDLQLLDGLEELTIAQKTPLRVLHRRPLASRSRTIHTMRTEYVDEHHFRLYLKTQAGTYIKEFVHGDFGRTKPNVGSIMETNADILELDVESVDVDWPPSLDD
What is the function of this protein?
Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm.  In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs.  tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs.  Does not show tRNA pseudouridylate synthase activity in the nucleus.  In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity.  Binds pri-miRNAs.
What are the official names of this protein?
tRNA pseudouridine synthase Pus10, tRNA pseudouridine 55 synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase Pus10 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Mitochondrion. Note=Localizes mainly in the nucleus. tRNA pseudouridylate synthase activity is restricted to the cytoplasm.
Protein: RXLRI_PHYIT
Sequence: MRLGYLIVGCAVALLATTDGVVDASSKHKQLSTDVPRPADDISSERFLRSQDTPEDDGNPAHEDRGYLTVLTNAAMHPLRERKMKNQIANLIKMDATDAELYAAGVQPHRLFDVIRHKDESVEMSLSQWVTMVHQHQFPSDYIWKSQAYRRFKQYAGFYDGMQRNGQRVASTT
What is the function of this protein?
Effector that leads to host programmed cell death.
What are the official names of this protein?
RxLR effector protein PITG_10232.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Host cytoplasm.
Protein: 2B_PEBV
Sequence: MTNWATLWPNDRLFLSDTYQLIWFDIEADRIEHKHFKAQNSEDISMIPKGFVSFVDNRLPMCINHKGEVYIRVGSFDTAYYQKFGDLDVSDFDDQVLPPDRDFTFNKVVFGDVPQEQLDNQIRDLQSEVSILTSRNVEMNVRENDLLKKVSELEKQIRQSSHNYEKVVEDGVVLSYRKAGGLLNRMVVLNRRLVGQRFVTNQRRWENIIMGSGVHDGSSYMAFNFKESGGSLKVTFDFDKLQNLSPDDLLAMQIA
What is the function of this protein?
May function by interacting with a small, flexible domain located at the C-terminus of the CP, forming a bridge between the virus particle and the internal surface of the vector nematode feeding apparatus.
What are the official names of this protein?
Protein 2b, 29.6 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the tobravirus protein 2b family.
What are the subcellular locations of this protein?
Virion.
Protein: MRAY_BURO1
Sequence: MLLALAQWLQGDASFLRLFTYLTFRAVMATITALGIGLVCGPWVIRKLTQMKVGQAVRKDGPQTHLVKSGTPTMGGVLILIGIAVATLLWGDLTNRFIWIVMLVTFGFGVIGWVDDYRKVVHKDPRGMSSREKYFWQSVIGLFAAVYLAFSVSEANNVRVFDLFMAWVRSGLSMGLPARADLMLPFLKSISYPLGVWGFIVLTYFVIVGASNAVNLTDGLDGLVIMPVVLVGASLGVFAYVMGSAVYSKYLLFPHIPGAGELLIFCSAMGGAGLAFLWYNTHPAQVFMGDVGALALGGALGTVAVIVRQEIVLFIMGGIFVAETLSVMLQVSWFKYTKKRYGEGRRLLKMAPLHHHFELSGWKETQVVVRFWIITLMLCLFGLTTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
Protein: LEUD_SALTI
Sequence: MAEKFTQHTGLVVPLDAANVDTDAIIPKQFLQKVTRTGFGAHLFNDWRFLDEKGQQPNPEFVLNFPEYQGASILLARENFGCGSSREHAPWALTDYGFKVVIAPSFADIFYGNSFNNQLLPVKLSDEQVDELFTLVKANPGIKFEVDLEAQVVKAGDKTYSFKIDDFRRHCMLNGLDSIGLTLQHEDAIAEYENKQPAFMR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: NDK_BEII9
Sequence: MAIERTFSILKPDVTRRNLTGAVNALIEKAGLRIIAQKRVLITKAQAETFYAVHSARPFFGELVESMISGPVVVQVLEGEDAIKKYREVLGATDPAKADAGTIRKEFALSVGENSAHGSDAPETAAVEIAQWFAGNELVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_CUPNH
Sequence: MKLTFLGAGAWGTALASHAAAANDVVLWGRDPAQLAAIAATRENAAYLPGVTLSERLAVQADFEQAVAHAADDADGIVVVATPVAGLREMTRRLAARGARPVSMLWLCKGFESGTHLLPHQMVRAELDAAGRTEGFAYGVLTGPSFAREVALGLPCALTVAGNEPSLAERAQAAFHHHAMRIYGSDDLTGVEVGGAVKNVLAIATGASDGLGLGLNARAALVTRGLAEMTRLGLALGGRVETFMGLAGVGDLILTATGDLSRNRKVGQQLAAGQSLEQILAGLGHVAEGVRCAQAVAELASAYGVEMPIARAVCAVLFDGLSAADAVAQLLQRDARDE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_STAAW
Sequence: MVKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: DNAJ_PROMH
Sequence: MAKRDFYEVLGLSKTADEKEIKRAYKRLAMKYHPDRNQGDKDSESKFKEIKEAYEVLSDPQKRAAYDQYGHAAFEQGGFGGQGGGGFGGADFSDIFGDVFGDIFGGGRRQQRAARGSDLQYNMDLTLEEAVRGITKEIRIPTLETCDKCHGSGAKEGTSAETCSTCHGAGQVHLRQGFFTVQQPCPTCHGRGKVIKEPCSKCHGDGRVERYKTLSVKIPAGVDTGDRIRLSGEGEAGEQGAPAGDLYVQVHVRQHHIFERDGNNLYCEVPINFAVAALGGEIEVPTLDGRVKLKIPAETQTGKMFRMKGKGVKSVRSHGVGDLMCRVVVETPVKLNEKQKQLMEQLGESFGGKGGEKNTPRSKSFLDGVKKFFDDLTK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_MYCMS
Sequence: MKKQLDKITPRNIDFSQWYTDIVLNTKLASYGPVKGTMIFRPYGYRIWELIQKYLDEEFKKVNVDNVYFPLLIPESLFNKEKDHIEGFSPEIATVTRVGQKKLEENLFIRPTSEVVMMDYFSNEINSYRDLPLIYNQWCNVMRWEKTTRPFLRTSEFLWQEGHTIHSSYNEAENFCLKILNIYEKFAKEILLLPVICGKKTEKEKFAGAKDTYTIESLMFDGQALQCGTSHFFADNFTKVYDIKFQNKENKLEHAYSTSWGVSTRLIGALIMTHSDDNGLVLPSKISPIQIQIIQIKNTEQIDQVVENIKDKLSDYRIDVDNSDKSFGFKISEAEIKGIPIRIEIGPRDLENNQITISRRDQQENKIKIDYKDVKKVVDQMIKDYDLSLYNSALENRKNRTFKANTIEEYIEILKQNQGFVLVPFCGRVECEQDIKTKTATNSRCIPFDQKEVKAKCFNCKKDTCLQVIFARAY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_COXBR
Sequence: MTRYIFITGGVVSSLGKGITSASLGAILEAQGLTVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFVNATMTRKNNFTTGRVYADVIRKERRGDYLGGTIQVIPHITDEIKAKIREGADGADVALVEVGGTVGDIESLPFLEAIRQMRIELGDQQTLFIHLTLVPYVAVAGEIKTKPTQHSVKELRSIGIQPDILVCRSEQSLPDAERAKIALFTNVPEPSVISLSDVKSIYEIPLILRDQGLGNRVCEKLNIKATAADLDDWKKVVQAQKNPRHTVTVAVVGKYVDLEDSYKSLSEALIHAGIHTQTRVVIEYIDSEAIELHGTELLKKVDAILVPGGFGSRGIEGKILAAQYARENGIPYFGICLGMQIAIIEFARDKAQMENANSTEFDPKTPFPVVALVSEWMAKEGIIEKRKWGDDLGGTMRLGGQPCRLKIDSLARRLYGEDRVIERHRHRYEVNNDLIGELEKKGLVISGRSIDDRLVEMIELADHPWFVGCQFHPEFTSTPRKGHPLFIGFIKAGLAAKEAKKAVLAAPSQEKTD
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: CYSD_ECOL6
Sequence: MDQKRLTHLRQLEAESIHIIREVAAEFSNPVMLYSIGKDSSVMLHLARKAFYPGTLPFPLLHVDTGWKFREMYEFRDRTAKAYGCELLVHKNPEGVAMGINPFVHGSAKHTDIMKTEGLKQALNKYGFDAAFGGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWHNYNGQINKGESIRVFPLSNWTEQDIWQYIWLENIDIVPLYLAAERPVLERDGMLMMIDDNRINLQSGEVIKKRMVRFRTLGCWPLTGAVESNAQTLPEIIEEMLVSTTSERQGRVIDRDQAGSMELKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: SHO1_PENRW
Sequence: MAKFRPSNILGDPFALMTISISILAWLIAFISSIIADVQTQYPNYSWWAISYMFCVIVGLVTTFGTDTGHVYGVAIVGYLACGLVLTSTSANNLIYGKQASMQAAGAGFILLSMIIILWIFYFGSTPQATHRGFIDSFALNKEQPGDPSYRGSRPMSSTFGARPDTVATNNTPQMYTSAQLGGFETSSPVSGYPGGAPGAERASSAPRFGTPNPSTPGNGEQEVGEVPQPTEYPYRAKAIYSYDANPEDANEISFAKHEILEVSDVSGRWWQARKQNGDTGIAPSNYLILL
What is the function of this protein?
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
What are the official names of this protein?
High osmolarity signaling protein sho1, Osmosensor sho1.
What is the protein family that this protein belongs to?
Belongs to the SHO1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRMD_HISS2
Sequence: MWIGIISLFPEMFKAITEYGVTGRAVRQNLLEIQYWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHCAKSVAGDGVKVIYLSPQGRKLDQNGVQELARNQKMIFVCGRYEGIDERLIETEIDEEWSIGDYVLTGGELPAMTLIDAVARFVPCVLGKQASAQEDSFAEGLLDCPHYTRPEQLNGLTVPPVLMSGNHEEIRKWRLKQSLQRTWLRRPELLESLALTDEQSKLLSQIKQENS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_ECO5E
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRPIPENRVAAGRNHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQVQLTPGEAPVCAQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: ATP5H_ARATH
Sequence: MSGAGKKIADVAFKASRTIDWDGMAKVLVTDEARREFSNLRRAFDEVNTQLQTKFSQEPEPIDWDYYRKGIGAGIVDKYKEAYDSIEIPKYVDKVTPEYKPKFDALLVELKEAEQKSLKESERLEKEIADVQEISKKLSTMTADEYFEKHPELKKKFDDEIRNDNWGY
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
What are the official names of this protein?
ATP synthase subunit d, mitochondrial, ATPase subunit d.
What is the protein family that this protein belongs to?
Belongs to the ATPase d subunit family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.