PharMolix/UniProtQA huggingface dataset:
Protein: APAH_COXBN
Sequence: MDARAINSREKADLKYPRNTYIIGDVQGCYRELQELLELIQFDSTKDRLGFVGDLVNRGPNSLEVLRFLKSLSSPLIVLGNHDLYLLILGYGLMPEDSYEHTLHAVLQAPDKLELLEWLRHCPLIRYEKSLSAVLVHAGLPPQWNIKESILHAEEISTALKGPHYLAFLKNLFGNEPSQWKDDLEGQDRLRYICNAFTRMRFCDAKGHLDLESEGKTNQAPSRFRPWFEWRNPQEDNVDIVFGHWAALNGQSSAPHTHALDTGCAWGYKLTAINLKTKERFSVPCQSALRM
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: PHF7_HUMAN
Sequence: MKTVKEKKECQRLRKSAKTRRVTQRKPSSGPVCWLCLREPGDPEKLGEFLQKDNISVHYFCLILSSKLPQRGQSNRGFHGFLPEDIKKEAARASRKICFVCKKKGAAINCQKDQCLRNFHLPCGQERGCLSQFFGEYKSFCDKHRPTQNIQHGHVGEESCILCCEDLSQQSVENIQSPCCSQAIYHRKCIQKYAHTSAKHFFKCPQCNNRKEFPQEMLRMGIHIPDRDAAWELEPGAFSDLYQRYQHCDAPICLYEQGRDSFEDEGRWCLILCATCGSHGTHRDCSSLRSNSKKWECEECSPAAATDYIPENSGDIPCCSSTFHPEEHFCRDNTLEENPGLSWTDWPEPSLLEKPESSRGRRSYSWRSKGVRITNSCKKSK
What is the function of this protein?
May play a role in spermatogenesis.
What are the official names of this protein?
PHD finger protein 7, Testis development protein NYD-SP6.
What are the subcellular locations of this protein?
Nucleus.
Protein: YEGS_PSEPK
Sequence: MQGRKAMLVLHGKQAMNEDVRSAVGDLRDSGWVLDVRVTWEAGDAQRLVAEALAAGYSHIVAGGGDGTLRDVAEAMGLAATQASLALLPLGTANDFAKAAGIPLEPASALALLNVAPQPIDLGQAGDQLFLNMATGGFGSQVTANTSEDLKKVLGAAAYLFTGLSRFSELQAASVELQGPGFHWQGDLLALGIGNGRQAGGGQVLCPEAMVNDGLLDVAILPAPQEVVGALRDLLGGDGLFVRARLPWVEIKSSQGLDINLDGEPLQAANLRFQARPAALHLHLPAGSPLLSHPG
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS-like.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_SHEB8
Sequence: MRPLTPRQAEILELIKRNIADTGMPPTRAEIATRLGFKSANAAEEHLKALAKKGCIEIMPGTSRGIRLTAEVEEVTETGLPLIGQVAAGEPILAQEHVEQYYQVDPSMFHPAADFLLRVKGDSMKNIGILEGDLLAVHKVQQARNGQVVVARVDDDVTVKRFEKKGNVVYLHAENEDYSPIKVDLGYQSLTIEGLAVGVIRNGDWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: PDXH_SHEPA
Sequence: MSEISGIRREYTLGELHNEEVPSDPMDLFNAWLEVIRDSDIKDPTAMSVATVDENGQPFQRIVLLKRFDNHGFVFFTNLESRKAQHIANNAQVSILFPWHSLDKQVAVTGIAEPLSKTEVLKYFMSRPKESQIASWVSKQSSPISARKALESKFAEMKAKFSQGDVPLPKFWGGYLVRPKSIEFWQGGEHRLHDRFIYTKKEESWEHTRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: UPP_SALNS
Sequence: MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: MTAP_CAEBR
Sequence: MVKVGIIGGSGLEDPNILLNPTAISIDTPYGQPSDHLIQGTINGVECVLLARHGRKHDIMPGNVNYRANLWALYSLGVDVIIASTACGSLKEEVAPGHLLFPDSVFDRTNSRKATFFDGTFSGAPGVSHIQAHPTYNEKLRQVLISTAEKCKLVHHRTGFGVCIEGPRFSTKAESMVFKSWGASLVNMTMMPECILAKELGIPYATTALVTDYDCWKDEDQVTAASVMKVFAANVEKAKTLFIEAVAEIGKIDWSAEILQTKTAARQSIMISPDVEVEFLKVPKT
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP, MTAPase.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BLM_CHICK
Sequence: MEEARAATNGGSGESQKLSNGEKSSQLEPGDVGNELLADIELEEDDYLDVVPPSPEEELPSFSPSVRNVSNIFKESPTDGRSAVHGTESEPELMAPKQPAAEQDSSAEHADKGLHLEQQLYSVMEDICKLVDAIPLHELTSISCAKELLQQRELRRKLLADSGALNTNSVNGPRNWKACVQQDPSSRPGTPLCSGPGRGVSSVGSTPKSTNLPSVLSRTVNSSSFSTIRNQTLDKLDTSYSSKETDQEVICLEPAALPSPKVNGKGSTSLSRPSEASFNGSWCEKPTGRDSGNWRVPERPTASTALKAQHTAPAGNPASGCWDVNDTDFDLDHFDIDDFDEGWEEAVAPEAAPEAPPAPQWQPLREGSASLRCRLLAAAAGSAPGPHPTAPKSGCGISAKSSSEPLVHNPAHERFRGMKFSHSEEMLKIFHRKFGLHSFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSAGVTVVISPLRSLIIDQVQKLKTLDIASTYLTGDITDADASKTYMQLSKKDPIIKLLYVTPEKVCASNRLLSALENLYNRKLLARFVIDEAHCVSQWGHDFRKDYKRLNMLRKKFHSVPMMALTATANPRVQKDIQNQLEMLKPQVFTMSFNRHNLKYDVLPKKPKKVAMDCLEWIKKYHPHDSGIIYCLSRHECDTTAAILQKEGLAALAYHAGLTDSNRDLVQKKWVNQEGCQVICATIAFGMGIDKPDVRYVIHASLPKSIEGYYQESGRAGRDGEMSHCLLFYSYSDVTRLRRLILMEKDGNSHTRQTHFNNLYSMVHYCENVVDCRRIQLLAYFGETDFNPNFCKDHPEVICDNCSRKKDYKSRNVTDEVKSIIRFVQQHCGQVGGINGNRNTGSGRYTLNMMVDIFLGAKSAKIQSGIFGKGAAYSRHNVERLFRKLVLDKILDEDLYITANDQAVAYVVLGEKAQAVLNGLLQVEFHETENASAIRKQRASVTKMSQREEMVKKCLGELTDTCKTLGKIFDVHYFNIFSTSTLKKIAETLSSDAEVLLQIDGVTEDKLEKYGAEIIKVMDKYSEWTTPEDAACQSVDTAPGSAGTPGSEEEAADDVVTSSYFGGNANQRRKRKRLPNSGESKRKKTSSGGSQQFYSKGARYRRARRAPGSRAAAPAQSSALRGAGARLGIMAPPKPSSRHFLQPSYAVL
What is the function of this protein?
ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:28228481).  Participates in DNA replication and repair (By similarity).  Involved in 5'-end resection of DNA during double-strand break (DSB) repair (By similarity).  Negatively regulates sister chromatid exchange (SCE) (By similarity).  Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (By similarity).  Binds DNA (PubMed:28228481).  Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity).
What are the official names of this protein?
RecQ-like DNA helicase BLM, Bloom syndrome protein homolog, RecQ helicase homolog.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YHAV_ECO57
Sequence: MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKNKDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Has RNase activity in vitro.  Acts as a transcription factor.  The YhaV/PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression (By similarity).
What are the official names of this protein?
Toxin YhaV, Ribonuclease YhaV.
Protein: UVRC_DICNV
Sequence: MNNSGFAFDPDVFLSHVSTLSGVYQMRDQNGTVLYVGKAKNLRQRLSHYFQKTGLSVKTRALMRAVYDIQTTSTPTEAEALLLENNLIKQYQPKFNILLRDDKSYPYICLSQHDFPRLFLYRGARKNGDFFGPYPNVQSAHHALAILQKVFRLRPCLDSFFKNRSRPCLQYQIKRCYAPCVGKISAEMYAQTVQHARDFLTGNSEHLLQTLTEHMLQASAAQQYERAAIVRDQISELRTIQQKQSMVVYAANVDVLAVATAYGKACVQVLFFRDGHSVTSQAFFPKLPELLPAGAILQAFIGQFYHQRPVPSQIVLSEALPDMDAVSEFLSQMSAHTVTLTTQPRAIRKKWLRMTQENARLNLRLHLAQKLSMHERFKALAQAFDWQKMPQRLECVDISHMQGEYTVASCVVFDRRGAVKSDYRRYKINGITGGDDYAAMKQVIKRRFARLKKGEGVMPDVFFVDGGRGQLQQAIAVFEEMQIEGVQLIGVAKGEGRKAGLEQFWFPHENRPRTLPADSQAMQLIIHIRDEAHRFAISAHRRGRDKKVRVSLLEEIPNIGRKRRQALLQHFGNLAGLMQASPEDITRVPGISVKLAAQIYAALHQGE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBA_CHLEL
Sequence: MTAILERRESASLWARFCEWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGYLLYGNNIISGAVVPTSNAIGLHFYPIWEAASLDEWLYNGGPYQLIVCHFFLGICCYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFIIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESRNAGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLASVEAPSIA
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y1410_SYNY3
Sequence: MKHKFLVSFLLGLTISFAGAQVIAKTPSVNNAPVARSVNQSPIQLEVIKSYQGHTLKGEAIIQIHYSQDGNYLLSTATDGLAKLWTADGELVREFAGKPVAMIFNGAFSRDGKAIITAGYNGVARIWDVQGNVLGEILGHTSAVTDVVFLSDDMGVVTSSDDGTIEGWSNIKEPLFTVTRPGVSRNMDFNAQTNLIAVTQDIGEITLLNPAGKVVRIIETDQGRLNDVDFSQDGKLLVTAGFDGTARVFNLDGQEILKIDVLDDGWVTGVAINQDNLIATVSDDGILRVWNLQGQLLGQYNPNLERLGSVSFHPNGKNLAIAAYHGTIILLELQ
What are the official names of this protein?
Uncharacterized WD repeat-containing protein slr1410.
Protein: NTPTH_PYRIL
Sequence: MTLRERAELKLGISGMPGVGKTTLVTKVLEVAKSKFAICGFITVEVRDGGKRIGFDIIDVNSGERKPFAREGIGMPSVGKYVINLGTCTLISKALRHKPCNLAIVDEIGAMEFKCPNFTTDLEEVVSNTPRILATIHRNYIGIAKRLGFEVIWLTRENWEMTYKQVLKRLGLSI
What is the function of this protein?
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP.  May hydrolyze nucleoside diphosphates with lower efficiency.
What are the official names of this protein?
Nucleoside-triphosphatase THEP1, NTPase THEP1, Nucleoside triphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the THEP1 NTPase family.
Protein: IDH3G_MACFA
Sequence: ISSQQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHIRVINGRAVEA
What is the function of this protein?
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate.  The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
What are the official names of this protein?
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, Isocitric dehydrogenase subunit gamma, NAD(+)-specific ICDH subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UDB11_HUMAN
Sequence: MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELYDIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTIERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAAHDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD
What is the function of this protein?
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
What are the official names of this protein?
UDP-glucuronosyltransferase 2B11, UDPGT 2B11.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: YGK2_YEAST
Sequence: MRLSDQFNNTTSSSDFFFSQLGDESSFDDNWNIWNSTLTQDLTVTGCQSVNNWSSFLRSRFQVLVSLVFWDQCPQFVQVQDWLPEMSLLLVEVSHTNLTEITWMVFIHVNSVVMLTTGHTSTTGVLSVLTDTTFTGCTKKIL
What are the official names of this protein?
Putative uncharacterized protein YGL102C.
Protein: IF2_MANSM
Sequence: MTDKETQNENAPKKLSLQRRVKTTVAGGKVQVEVRKSRKIDTEAAKKAAEEAKLKAQEAAEKAAAEKAEKEAAEKAKKNAEKARVAAAVKKPEPVKVVDAEKDRIKAEEAELRRKADELARQKAEEQARKAAEEAKRLAELAADRETTEVSDDFSDYHLTSTYAREAEDEEERRKEGRGRGKNKVGKAKKGGRDDNGSKDERNADRRNQKDVKGKGKQGKKGSSAIQQAFTKPAQAVNRDVVIGETITVAELANKMAVKATEIIKTMMKMGEMVTINQVIDQETAQLVAEEMGHKVILRKENELEESVLEDRDVNAEKVTRAPVVTIMGHVDHGKTSLLDYIRKAKVAAGEAGGITQHIGAYHVETNGKMITFLDTPGHAAFTSMRARGAKATDIVVLVVAADDGVMPQTIEAIQHARAASVPLVVAVNKIDKPEANPDRVEQELLQYDVVSEKFGGDTQFVYVSAKKGTGVDELLDAILLQSEVLELTAVKEGMATGVVIESYLDKGRGPVATILVQSGTLNRGDILLCGFEYGRVRAMRDELGKDVESAGPSIPVEVLGLSGVPAAGDEATVVRDEKKAREVALYRQGKFREVKLARQQKAKLENMFSNMAEGDVAELNVIVKADVQGSVEAIVQSLQELSTEEVKVKVVGSGVGGITETDATLAAASNAIIVGFNVRADASARRIIETENIDLRYYSIIYELLNEIKAAMSGMLQPEFKQEIIGLAEVRDVFRSPKFGAIAGCMVTEGVIKRNNPIRVLRDNVVIFEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVKVGDQIEVFEVVEIKRSI
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HELI_PSHV1
Sequence: MAEDRGTRLWQFPDHVYLNFTAMHGIQHVVDRISSLAEESVTPAERPPLSWFEAVARADSPDEVPPRELPFRVYLITGNAGSGKSTCIQALTEMLNCVTTGSTRVAALNVFTKLSSAYTSPAIQTIFHDFGFKGSHVQAVLGKFKYPKQPDPKSLVDAQMSDLYYYWDVLKDIANKVVEGGLPETMRVLLSLELKSGKPFTDAAPFLSAATPALIRSNVVLIDEAGVLGKHILTAVVFSWWLHNALWQTRRYAEGKVPVIVCIGSPTQTDAMESVFEHSTLRHLVSNKTNILSHLIRSSEMAERMNLNRNWTIFINNKRCTEQDFGNVLKAFEFGLPMNEGHARFLDQFVVSESYIKDPSKLPGWTRLFASHDDVKVYMSRLHANLRARRSDKFKVFVLPIYTVVSLEAFDKYKELTGQTSLTMEKWLTANASRLGNYSQSRDLDVTTPRFEYGTADGKKFALITTDASHVLNSQISVTKRVKKLVFGFEGSFGDFAAVLSEDTFFKKHGEDHVEFAYRFIAALLFSGMIAFYDFLRTEGLPQDKVDAAYSRLQAVTADLLAATHEQLGIAAAAGAQTGSGARRSRNADAFAFDDDASEEVTDAELDDLFGAMTDNSMDAFYLNYEKLPADAHGQEIFFHFDMLKRLFSERYDALSGLFGKTFTSAPFRTFVGQASFNGSNAFVSSFSGGILSFTSQTDAYTLRGVTRAPVPCFVDELFRGRDWAAAILRETDMPRVVVSDSMGFVSVINHNMSTFVDNVSGEELQMAATVDHGISSNLAMTITRSQGLGLDRVAICFATSQLKLNTAYVAMSRVTSCRYLRMNVNPLRTHYEDTRRVSAHILAALRCKDVKLVY
What is the function of this protein?
Component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs.  Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
What are the official names of this protein?
DNA replication helicase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae helicase family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: APOE_CERSC
Sequence: MKVLWAALVVTLLAGCGADVEPGPEVQLGKEWATWQASQPWEQALGRFWNYLRWVQTLSEQVQEQLLSSQVTEELTALMDDTMKEVKACQSELEEQLGPVTEETKARVSKELQAAQARLGADMEEVRSRLAQYRGELQAMVGQSTEELRGRLSAHLRKMRKRLLRDAEDLQRRLAVYQAGIWEGAERSVNTLREHLGPLAEQAATVHTLVSKPLQERAEAWAQRLRGRLEKAGFPVGDRLDEVREQVQEVRAKVEEQANQVRLQAEAFQGRLKSWFEPLVQDMQQKWAELVEKVQLAVGAVPTSVPSEKQ
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: NENF_RAT
Sequence: MARPAPWWWLRPLAALALALALVRVPSARAGQMPRPAERGPPVRLFTEEELARYSGEEEDQPIYLAVKGVVFDVTSGKEFYGRGAPYNALAGKDSSRGVAKMSLDPADLTHDISGLTAKELEALDDIFSKVYKAKYPIVGYTARRILNEDGSPNLDFKPEDQPHFDIKDEF
What is the function of this protein?
Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960).  Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity).  Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity).  Neurotrophic activity is enhanced by binding to heme (By similarity).  Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity).
What are the official names of this protein?
Neudesin, Neuron-derived neurotrophic factor, SCIRP10-related protein, Spinal cord injury-related protein 10.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b5 family. MAPR subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space. Mitochondrion. Endoplasmic reticulum. Note=Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7.
Protein: TRMB_MACCJ
Sequence: MRMRNKPWAEDFLLQHDDIVSIDLARKDHIVDWFDQVQPIHIEVGSGMGRFITEMAKAHPEINYIGIERDKNVMIRIVEKAVEQNIRNLRLLTVDAEKLTEIFNEGEIDRIYLNFSDPWPKARHAKRRLTHENFLKVYETILDKDGEIHFKTDNQALFEYSIESMSHYGMKLKNINLNLHDNEPEDNIRTEYEDKFSNKGFRINRLEARF
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: SURA_ECOLI
Sequence: MKNWKTLLLGIAMIANTSFAAPQVVDKVAAVVNNGVVLESDVDGLMQSVKLNAAQARQQLPDDATLRHQIMERLIMDQIILQMGQKMGVKISDEQLDQAIANIAKQNNMTLDQMRSRLAYDGLNYNTYRNQIRKEMIISEVRNNEVRRRITILPQEVESLAQQVGNQNDASTELNLSHILIPLPENPTSDQVNEAESQARAIVDQARNGADFGKLAIAHSADQQALNGGQMGWGRIQELPGIFAQALSTAKKGDIVGPIRSGVGFHILKVNDLRGESKNISVTEVHARHILLKPSPIMTDEQARVKLEQIAADIKSGKTTFAAAAKEFSQDPGSANQGGDLGWATPDIFDPAFRDALTRLNKGQMSAPVHSSFGWHLIELLDTRNVDKTDAAQKDRAYRMLMNRKFSEEAASWMQEQRASAYVKILSN
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins, such as OmpA, OmpF and LamB (PubMed:8985185).  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins (PubMed:8985185).  May act in both early periplasmic and late outer membrane-associated steps of protein maturation (PubMed:2165476).  Essential for the survival of E. coli in stationary phase.  Required for pilus biogenesis (PubMed:16267292).
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA, Survival protein A.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: EFTS_DICTD
Sequence: MEITIEMIKELRERTGAGVMEAKKALEEANGDMEKAVTILREKGVIKAAKKAGRVAKEGIIEAYIHTGDKLGVLVEINCETDFVARTDEFRKLAKDIALQIAGMNPQYVSKEDVPPEVIEKEKEIYRTQLRNEGKPEHVIEKIIEGKLEKFYEEVCLLEQPFVRNPEIKVKDLITEAISKLGENIVVRRFARFVVGEE
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YM14_YEAST
Sequence: MTYPKRIPINAWSEVHRVARPLIITFDAYNTLYATKLPVMEQYCIVGRKYGIKANPSTLTNNFPHVFKKLKEDYPQYGKYSGIKPEQWWSILIRNVFAPNEIPDEMINEILMRFEGFDSYFVYPDLIKFLKDLKSRHPDVILGIVSNTDPIFYKLLKNIGLFETFSGHIYLSYELNLAKPDRAIFQYALDDIISKQPHLLEKYTREEILQHCFHIGDELKNDLEGAEAAGWTGILLDRNDKYGFLSNSISKPMRDEYKLSIDKIDNNSINTWEANTKQTDTLQLSERKYVVSNLEVLEELFP
What are the official names of this protein?
Uncharacterized protein YMR130W.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
Protein: GAL1_STRTD
Sequence: MNTSQLREKFKEVFGVEADHTFFSPGRINLIGEHTDYNGGNVLPVAITLGTYGAARKRDDKVLRFFSANFEEKGIIEVPLENLRFENEHNWTNYPKGVLHFLQEAGHTIDSGMDIYIYGNIPNGSGLSSSSSLELLIGVIVEKLYDLKLERLDLVKIGKQTENDFIGVNSGIMDQFAIGMGADQCAIYLDTNTLKYDLVPLDLKDNVVVIMNTNKRRELSDSKYNERRAECETAVSELQEKLDIQTLGELDLWTFDAYSYLIKDENRIKRARHAVLENQRTLQARKALEAGELEGFGRLMNASHVSLKYDYEVTGLELDTLAHTAWEQEGVLGARMTGAGFGGCAIALVNKDKVEDFKKAVGQRYEEVVGYAPSFYIAEVTGGSRVLD
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.