PharMolix/UniProtQA huggingface dataset:
Protein: AUSP_PENBI
Sequence: MEVVRYFTRNQKQLPATGPNDSIVQLPDIPPCYECNVEVALRFDSSLDSEKLQQSLKQLLEIGNWRQLGGRVRRRDTNPSACNYDLHVPAEFTTERPAFNYQIWELSGAIDEHPTASKMPRPTDPKKVSFYNVGDARSPLRTRTRYPRKAQEWADSDLPPLSFEQLSFRDGTIILLVFPHILMDATGYGLFLKAWTSVLQGRIDHVPQCCGFSESTTDMLGHKTPAGAFTWHNHLLKGLDSLKFTAGLLWENRWGKEDRVIRVPAKFIMHTRDKVLADLSTSQPSPFVSQSDVLIAWFTRVVLAALKPLQRRTLVLTNAFDTRHMLPPERAYLQNSVCMAHTMLPVGEVLYNPVSFLANEIRRSLVRERTEEQIQARCAWAKDVGIMPLLGTSDMLLCNVSNWSKGNLVDLDLCHAAVTEHRGPCVPSSILNCSQMGGVTPNYGIILGKDSQDCWWMQWHLPKFCWAGIERELDTINQIRWE
What is the function of this protein?
O-acyltransferase; part of the gene cluster B that mediates the biosynthesis of the fungal meroterpenoid acetoxydehydroaustin (PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (By similarity).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (By similarity).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG then modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:29076725).  The cytochrome P450 monooxygenase then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:29076725).  The hydroxylation catalyzed by ausR permits the second O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:29076725).  Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end product of the Penicillium brasilianum austinoid biosynthesis clusters is acetoxydehydroaustin (PubMed:29076725).
What are the official names of this protein?
O-acyltransferase ausP, Austinoid biosynthesis clusters protein P.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: YIDD_HELPY
Sequence: MRNNKTPFLSAIFTASIRGYQRFFSAFTPSSCRFYPTCSNYALWLLCFESPLSAMGKIAIRILSCNPFCSGGIAYPTTRLKRPSLIQSHKDSNRNFKTITFWLVPTKSHATYYIIKV
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BETA_STAA2
Sequence: MSNKNKSYDYVIIGGGSAGSVLGNRLSEDKDKEVLVLEAGRSDYFWDLFIQMPAALMFPSGNKFYDWIYSTDEEPHMGGRKVAHARGKVLGGSSSINGMIYQRGNPMDYEGWAEPEGMETWDFAHCLPYFKKLEKTYGAAPYDKFRGHDGPIKLKRGPATNPLFQSFFDAGVEAGYHKTPDVNGFRQEGFGPFDSQVHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGRRATGVTYKKNGKLHTIDANEVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGENFEDHLEVYIQHKCKEPVSLQPSLDIKRMPFIGLQWIFTRTGAAASNHFEGGGFVRSNNEVDYPNLMFHFLPIAVRYDGQKAAVAHGYQVHVGPMYSNSRGSLKIKSKDPFEKPSIRFNYLSTEEDKKEWVEAIRVARNILSQKAMDPFNGGEISPGPEVQTDEEILDWVRRDGETALHPSCSAKMGPASDPMAVVDPLTMKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKAADIIRGRKPLEPQYIDYYKHGVHDENEGAIEVKPYAK
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: OLFL1_HUMAN
Sequence: MMVALRGASALLVLFLAAFLPPPQCTQDPAMVHYIYQRFRVLEQGLEKCTQATRAYIQEFQEFSKNISVMLGRCQTYTSEYKSAVGNLALRVERAQREIDYIQYLREADECIESEDKTLAEMLLQEAEEEKKIRTLLNASCDNMLMGIKSLKIVKKMMDTHGSWMKDAVYNSPKVYLLIGSRNNTVWEFANIRAFMEDNTKPAPRKQILTLSWQGTGQVIYKGFLFFHNQATSNEIIKYNLQKRTVEDRMLLPGGVGRALVYQHSPSTYIDLAVDEHGLWAIHSGPGTHSHLVLTKIEPGTLGVEHSWDTPCRSQDAEASFLLCGVLYVVYSTGGQGPHRITCIYDPLGTISEEDLPNLFFPKRPRSHSMIHYNPRDKQLYAWNEGNQIIYKLQTKRKLPLK
What are the official names of this protein?
Olfactomedin-like protein 1.
Protein: FCERG_CAVPO
Sequence: MYPAVVLLLLLLVEQAAALGEPQLCYILDAILFLYGIILTLLYCRLKIQVRKATVASYEKPDGIYTGLSTRNQETYETLKHEKPPQ
What is the function of this protein?
Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors.  As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells.  As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset.  Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells.  Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes.  May function cooperatively with other activating receptors.  Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation.  Also involved in integrin alpha-2/ITGA2-mediated platelet activation.
What are the official names of this protein?
High affinity immunoglobulin epsilon receptor subunit gamma, Fc receptor gamma-chain, FcRgamma, Fc-epsilon RI-gamma, IgE Fc receptor subunit gamma, FceRI gamma.
What is the protein family that this protein belongs to?
Belongs to the CD3Z/FCER1G family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: AROA_DEIGD
Sequence: MTDGLPERFDVLVHPVSELRGELRAQPSKNYTTRYLLAAALAEGETRVVGAATSEDAEALIRCLRAWGADVDRVGEDVVVRGFGAHPRAGMTLNPGNAGAVARFLMGVAALTTDTTFVTDYSESLGRRPQGDLLAALERLGARVSSRNGQLPVTLSGPVRGGRVEVSAQRSSQYASALMFLGPLLPDGLDLRLTGEIKSHAPLRQTLDTLAAFGLQARASADLTRITIPGGQAYRPGRVLVPGDYPGSAALLVAAALLPGEVTVTNLREGDLQGEREALNVLRAMGADLVREGDRVTVRGGRPLHAVTRDGDSFTDAVQALTAAAAFARGTTTWENVATLRLKECDRISDTRRELERLGLTATETADSLSITGADRIPGDLTADGHGDHRMIMLLTLLGLRAEAPLRITGAHHIRKSYPLFFRHLEELGAHFEYLPTDAA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C3H22_ARATH
Sequence: MASEENNDLENLLDIQLIEQKESLSSIDEALLSDPSNPELLSVHEELLSAIKEVEEGLLHLKRARLLEEADIVLNGLNHDAGVKPEHLEPEKTEEKKDLDGSKCRFRHTDGRWYNGRIIGFEGSDSAKISFLTPTSESMMICKFFMQQRCRFGSSCRSSHGLDVPISSLKNYEQTEWKQLMVGSKIWAVSGSKYDIWRKAELESWDDELQVGGVVFRDDKSSAKLGSDSLALSEYAQMTDDDGEEEEEEDEQQSASDSEDSVSSDYDEGSPQGIGFLESTNLPRGVQTDTALFAKWENHTRGIASKMMASMGYREGMGLGVSGQGILNPILVKVLPAKRSLDYALEHIRNGECKSEKQKKKRSRGGKRKRGKKFAEAAKAAKQEEESKPDLFSLINEQIFPTRHEKVHSESVKNRQNKGPVDRKALVEYQDEVRDLKLEMLKLEQMVNRNKKDLVVSEAATRRLKEVRKALASTLACQAAASNAIVSKENEKKWLKF
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 22, AtC3H22.
Protein: POLG_DEN1C
Sequence: MNNQRKKTGRPSFNMLKRARNRVSTGSQLAKRFSKGLLSGQGPMKLVMAFIAFLRFLAIPPTAGILARWSSFKKNGAIKVLRGFKKEISSMLNIMNRRKRSVTMLLMLLPTALAFHLTTRGGEPTLIVSKQERGKSLLFKTSAGVNMCTLIAMDLGELCEDTMTYKCPRITERQPDDVDCWCNATDTWVTYGTCSQTGEHRRDKRSVALAPHVGLGLETRTETWMSSEGAWKQIQKVETWALRHPGFTVIGLFLAHAIGTSITQKGIIFILLMLVTPSMAMRCVGIGNRDFVEGLSGATWVDVVLEHGSCVTTMAKNKPTLDIELLKTEVTNPAVLRKLCIEAKISNTTTDSRCPTQGEATLVEEQDANFVCRRTFVDRGWGNGCGLFGKGSFLTCAKFKCVTKLEGKIVQYENLKYSVIVTVHTGDQHQVGNETTEHGTIATITPQAPTSEIQLTDYGALTLDCSPRTGLDFNRVVLLTMKKKSWLVHKQWFLDLPLPWTSGASTSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKCRLKMDKLTLKGMSYVMCTGSFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVIDKEKPVNIEAEPPFGESYIVVGSGEKALKLSWFKKGSSIGKMFEATARGARRMAILGDTAWDFGSIGGVFTSVGKLIHQIFGTAYGILFSGVSWTMKIGIGILLTWLGLNSRSTSLSMTCIAVGMVTLYLGVMVQADSGCVINWKGKELKCG
What is the function of this protein?
Disrupts the host endothelial glycocalyx layer of host pulmonary microvascular endothelial cells, inducing degradation of sialic acid and shedding of heparan sulfate proteoglycans.  NS1 induces expression of sialidases, heparanase, and activates cathepsin L, which activates heparanase via enzymatic cleavage.  These effects are probably linked to the endothelial hyperpermeability observed in severe dengue disease.
What are the official names of this protein?
Genome polyprotein.
What are the subcellular locations of this protein?
[Capsid protein C]: Virion. Host nucleus. Host cytoplasm. Host cytoplasm, host perinuclear region. SUBCELLULAR LOCATION: [Peptide pr]: Secreted. SUBCELLULAR LOCATION: [Small envelope protein M]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Envelope protein E]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Non-structural protein 1]: Secreted. Host endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note=Located in RE-derived vesicles hosting the replication complex.
Protein: P55G_BOVIN
Sequence: MYNTVWSIDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAITNGIKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELISHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRKEGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIRLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYGSLKELVLHYQRTSLVQHNDSLNVRLAYPVHAQMPTLCR
What is the function of this protein?
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity.  During insulin stimulation, it also binds to IRS-1.
What are the official names of this protein?
Phosphatidylinositol 3-kinase regulatory subunit gamma, PI3-kinase regulatory subunit gamma, PI3K regulatory subunit gamma, PtdIns-3-kinase regulatory subunit gamma, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit gamma, PI3-kinase subunit p85-gamma, PtdIns-3-kinase regulatory subunit p85-gamma, p55PIK.
What is the protein family that this protein belongs to?
Belongs to the PI3K p85 subunit family.
Protein: RL4_RICAH
Sequence: MKTKILSLANEEVGEISLNEDIFAVEFIRDDVIKQVIDWQRAKAMSGNHKTKTVSEVSGTTKKPFKQKGTGNARQGSLRSVQMRGGGVAHGPRVRSHVTKLPKKVRKLGLIHALSEKFAEGRLLVIDSLKLDQPKTSALVNILSKFQGKSFFVIDGNEVDTNFSLAAKNIYNTAIVPQIGANVYDIIRYEYVLLSQEAVSVLEERLR
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: IMDH_STAS1
Sequence: MWENKFEKESLTFDDVLLLPAESDVLPKEVDLSVQLSEGIKLNIPVISAGMDTVTESKMAISMARQGGLGVIHKNMNIEDQADEVQKVKRSENGVISNPFFLTPEESVFEAEALMGKYRISGVPIVNNKEDRQFVGIITNRDLRFIEDFSIKISDVMTKEQLVTAPVGTTLDEAEKLLQQHKIEKLPLVKEGRLEGLITIKDIEKVLEFPNSAKDEHGRLLVGAAIGIAKDTDIRAQKLVEAGVDALVIDTAHGHSKGVLEQVKHIKETFPQVTLIAGNVATAEGTKALYEAGADVVKVGIGPGSICTTRVVAGVGVPQITAVYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEVFQGRQYKVYRGMGSLGAMESGSNDRYFQEDKAPKKFVPEGIEGRIAYKGSLQDTIYQLMGGVRSGMGYTGSRNLEALREEAQFTRMGPAGLAESHPHDVQITKESPNYSF
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: PORF1_RAT
Sequence: MPYSLQPQPEGFADVPGFPLCMYMVRGSTWTLVPPDL
What is the function of this protein?
Precursor for a gonadotropin regulatory hormone (GNRH) related decapeptide.
What are the official names of this protein?
Putative preoptic regulatory factor 1, PORF-1.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: SECM_ECO57
Sequence: MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS
What is the function of this protein?
Regulates secA expression by translational coupling of the secM secA operon.  Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
What are the official names of this protein?
Secretion monitor.
What is the protein family that this protein belongs to?
Belongs to the SecM family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Periplasm. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.
Protein: PSRP_LEGPA
Sequence: MKRYVFMLSDGTGITAETLGNSLITQFENIQFEKITIPYIDSTHRAESVVLRINQCFSEQGTKPLVFMTLVDPEIRQAIKKAHACVFDLFSIFIGPLENELEEKSSYTVGRTHGVANVKSYSHRIEAIDFALSHDDGIKTRGYDKADIILIGVSRCGKTPSCLYMALQYGILAANYPFTEEDLVGFRLPEVLRPYKPKLFGLTIDAQRLQQIRSERRPNSKYASAEQCRLEVTEVEAMYQRENIPYINSTKYSIEEISTKVLAIAGLQRKI
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: FER2_SPIOL
Sequence: ATYKVTLVTPSGSQVIECGDDEYILDAAEEKGMDLPYSCRAGACSSCAGKVTSGSVDQSDQSFLEDGQMEEGWVLTCIAYPTGDVTIETHKEEELTA
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin-2, Ferredoxin II.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ILVC_CHLSY
Sequence: MAELYYDNQADLNRLKNKPIAIIGFGSQGHAHARNLADSGLDVRVGLYPGSKSWAKVEAAGLKVMTVAEAAREAQIVMILTPDIGQADLYREHIAPAMEPGKTLMFAHGFNIRFGQIIPPQGIDVSMVAPKAPGHRVREVFVQGGGVPALIAVEQDATGGAFEDALAYAKGLGCTRAGVLRTTFAEETETDLFGEQVVLCGGVSALVKAAFETLVEAGYQPEVAYFECMHELKLIVDLFYQGGLNYMRYSVSDTAEWGDYTAGPKIITDQTRAAMRQILADIQSGAFAEDWIDENHNGRPRFNAYRQADINHPIEQIGRELRRMMPFVNPREVKPGEGGA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ILVC_CORGB
Sequence: MAIELLYDADADLSLIQGRKVAIVGYGSQGHAHSQNLRDSGVEVVIGLREGSKSAEKAKEAGFEVKTTAEAAAWADVIMLLAPDTSQAEIFTNDIEPNLNAGDALLFGHGLNIHFDLIKPADDIIVGMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTGTAQALTLSYAAAIGGARAGVIPTTFEAETVTDLFGEQAVLCGGTEELVKVGFEVLTEAGYEPEMAYFEVLHELKLIVDLMFEGGISNMNYSVSDTAEFGGYLSGPRVIDADTKSRMKDILTDIQDGTFTKRLIANVENGNTELEGLRASYNNHPIEETGAKLRDLMSWVKVDARAETA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: PHPC_STRVT
Sequence: MTAVFPGELLLAEGIHEIARVTALLSGPLRRAPRVAQVVGPGFAGRPWAPRLTDALRPLDPTVVVHDGPTTPDSVAALARQLRAIRADVAVAIGGGTVMDAAKAAAALADGGPPDADRVRQACAAGPAAGDTPPAVRVVAVPTTAGTGAEATPFATLWDLKHRRKLSLTGPRVRPSAAVLAPELLAGLGRRALATGILDALCQGAEASWSIRSTPESIRWGTSAVTLAAEALDQVQDDAPDAAARLALQRAAHHSGRAIALAQTSSCHAISYPLTLRLGLAHGHACGVTLGRLLRYNHAVPAGDCADPRGTGHVRRVLDALAAPLGGTPARAALRVERFITACGLTPYDALDVDHRSLAAEAVTYPRCHDNPRRLDRESLGRLLGERSEMEETCG
What is the function of this protein?
Catalyzes the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate, a step in the biosynthesis of phosphinothricin tripeptide.  Phosphinothricin tripeptide is both a natural-product antibiotic and potent herbicide.  Can use both NAD and NADP but the preferred substrate is NAD.
What are the official names of this protein?
Phosphonoacetaldehyde reductase.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family.
Protein: PYRB_AERHH
Sequence: MTNPLYKKHVISISDLTRPDMELVVATAQRLKAEPDTRLLKDKLVASCFFEASTRTRLSFETAVQRLGGNIIGFADGGNTSAKKGETLADSIKIIGSYTDAVVMRHPKEGAARLASEFSRVPVINGGDGSNQHPTQTLLDLFSIHETQGKLDGLNVAFVGDLKYGRTVHSLAQALSLFNCRFFFISPEALAMPDYICEELEEKGIQFSVHETMEEVMPELDILYMTRVQKERFDETEYKHMAAKFVLEVATLEGAKPTMKILHPLPRVDEIDVAVDKTPHAYYFQQAENGVYARQALLALVLNETV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: V026_FOWPN
Sequence: MWLFPERVYYLKNENLLISFYIECYLTITTMFLDDDTPHEESTVQPYSINLVRRLMEGNTKDEGIRVLRMAIKFERIDIIKILLEYGVNVNENEYYEEELTCYSVLHFAVDIGNKDIVSILLYAGADVNNTRCYLRNTPLHLAIQQKNTDIAKLLLDSGADQNITNENGNIPIQIAVTYNDEKMVNILLQYSPNLEIADYNGRTVLHNAVLDKNINIVSLLLENGALVDSKCIEGYTILLSSVNRTDPFIIKMLLHRGANPFFLNIKLNHIPLTWYCYCHGNSLSMTVKDLISSAVMISHIRDKVKLTPGFKINEDFTNSIYRFNYYKNLCEEEIRNMKIRRAGYKLTVFDFIKAGKQDDHNTLARCIELLLVGVNKNEFQIYGDIIDQYIKIGLYRKEQLDRVVNSLTSTITNLPYEVIYIIVEKMTNKELCEIR
What are the official names of this protein?
Putative ankyrin repeat protein FPV026.
Protein: QUEC_SYNC1
Sequence: MSKKAVVLYSGGLDSTTCLAEARAAGFTPYALSFHYGQRHTVELEKARLYAPQVGAADHMVIDFDLRRIGGSALTSDEEVPKGREIDDAIPVTYVPARNTIFLSFALGWAEVLGSFDIFIGVNALDYSGYPDCRPEFISAFEQLANLATKAGVEGQGQYRVHAPLLHLTKAQIIKRGLELGVDYSLTHSCYDPTPEGLACGLCDSCQLRLKGFAEAGISDPAAYAREVQR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: NCE2_SCHPO
Sequence: MVGIRQYGVFTWVFRTFQLAIDTIVLALASALVNQQTSGGSPGKINFSVAVGSFAILTFFLTAVGRFLPTILGNPWLIAFYDFVNWVFALTGGCCIAVAIRVHACDNQKYLDRNHYTQGSMRRCQELKALCFFLWFMFGLYVASFIVQIFIAKNDTPNYTFRGRGRGKGSGPAVAPRPVMSAV
What is the function of this protein?
Involved in membrane organization and might act as a sensor of sphingolipids that regulates plasma membrane function.  Involved in a novel pathway of export of proteins that lack a cleavable signal sequence.
What are the official names of this protein?
Non-classical export protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the NCE102 family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: NDHJ_SOLTU
Sequence: MQGRLSAWLVKHGLIHRSLGFDYQGIETLQIKPEDWHSIAVIFYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIEDDVDQPEELCIKVFASRRNPRIPSVFWVWKSVDFQERESYDMLGISYDNHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAH
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: FA10_RABIT
Sequence: MANPLHLVLLGAALAGLLLSGSSVFISRRAANDVLARTRRANSFLEELKKGNLERECMEENCSYEEALEVFEDREKTNEFWNKYVDGDQCESNPCQNQGTCKDGLGMYTCSCVEGYEGQDCEPVTRKLCSLDNGGCDQFCKEEENSVLCSCASGYTLGDNGKSCISTELFPCGKVTLGRWRRSPATNSSEGPPEAPGPEQQDDGNLTATENPFNLLDSPEPPPEDDSSSLVRIVGGQDCRDGECPWQALLVNEENEGFCGGTILSEYHVLTAAHCLHQAKRFKVRVGDRDTEHEEGNEETHEVEVVVKHNRFVKETYDFDIAVLRLKTPITFRRNVAPACLPQKDWAESTLMAQKTGIVSGFGRTHEMGRLSTTLKMLEVPYVDRNSCKRSSSFTITQNMFCAGYDARPEDACQGDSGGPHVTRFRDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIEKSMRARAVPVAEAAGTPGPTQPTIKGSPS
What is the function of this protein?
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
What are the official names of this protein?
Coagulation factor X, Stuart factor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.