PharMolix/UniProtQA huggingface dataset:
Protein: ACCD_CYACA
Sequence: MPNGTKLAKSFLWKKCDSCNILISKFDFYKHDKVCPECNYHFPMYSSERINHIIDLKSWIPLYNNLLSGDPLGFCDKKPYITRLAENQKITGLDEAVQTGIGRINNISASVAVMDFNFMGGSMGSAVGEKITRLVEFSTKEELPIVIISASGGARMQEGILSLMQMAKISAALERLQSKGLLYISILSSPTTGGVFASFAMLGDIILAEPKAVVGFAGKRVVEQTLNEKLPPNFQSAEYLLDNGFVDLIVKRKQLKKTIHMILDLHN
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: CF122_HUMAN
Sequence: MMPRHLLPHSGITSLRRVPRRRLPSRRREDFRRCLFLSFVSTDKDGDPTGQASPAVPVPHFTTWGSLIPIDSQRNKERTRFTWMDGPPHGGLGTRFSGRGSASLTAPPGRCFTRERHPVPRQRKCRRQHSTGRKPHCGTRSAAPRNPKSIHKRSFSAKSLKNKTRNESPPVSALVSRTKTQPGQLHFCCQPSSSQAPASRRAKGR
What are the official names of this protein?
Putative uncharacterized protein encoded by LINC00242.
Protein: PUR5_THEPX
Sequence: MNYKDAGVNIDEGNKLVKMIKPIAKTTLTANVLEGIGGFAGLFEIKNYKNPVLISSTDGVGTKLKIAFMMDKHDTVGIDLVAMCVNDVIVTGAKPLFFLDYFATGKLKSETAVEVIKGIAEGCKIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKEELIDTKSIKKGDAIIGLASSGIHSNGYSLVRKVFFEKNNFSVKDFIPELGMNLGDALLTPTKIYVKSIEALKELKIKGMAHITGGGFIDNIPRILRKSIAAKINKGSWKIPTIFNLIQRLGDIEEREMYRTFNMGIGMVVIVDPSDVDKALEKLNGIGEKAYVIGEIVESEGGVIL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IPI3_PICST
Sequence: MDESVFYIAEGDPNDKHSQESFALATSIHNSQQHASFRQADAPKNGAILSGSGQGERLIVAAPNKALLNVYSWGKESPDQRIPLPEALTCLALVEHPNTRLFSEFHRNSEFKLPSYRVPWLLAGGSKSGKIYVWELSSGSLLCVKEAHYQNVTVVKFSKCGTFLVAGSDDARCTVWKTLDLIAVFDGDNDESSRNFKPYLAITDNTLAVTDLVLNEPGVINDLKLYTVSRDNTLRIYDIITKQLLTTFILSEAIESVVADPAGRAVYVGLSNGLIRTIPLYNINPNTSVLESIGGNQKIITVESDPNLKFTFLHHQQRISADANKTSILHKNLNNKKNDTENANKPIHVTKLAISLDGTNLISGDSLGRVYVSDIVTRQVVKTFTPCNSPISQIQVSSAPFEALNVSSNSKVDKKHRLIPQLKRVLTGRDATEHQLNLEIPSESRDESDENFAVWLSRKTQEDLEFKNLSGVNSSVKKVANITSDSESKKELEDKLAKLSSAYTQLRSKHEELLKEHSKVLNNKA
What is the function of this protein?
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
What are the official names of this protein?
Pre-rRNA-processing protein IPI3.
What is the protein family that this protein belongs to?
Belongs to the WD repeat IPI3/WDR18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNM5_STAA8
Sequence: MKINEFIVVEGRDDTERVKRAVECDTIETNGSAINEQTLEVIRNAQQSRGVIVLTDPDFPGDKIRSTITEHVKGVKHAYIDREKAKNKKGKIGVEHADLIDIKEALMHVSSPFDEAYESIDKSVLIELGLIVGKDARRRREILSRKLRIGHSNGKQLLKKLNAFGYTEADVRQALEDE
What is the function of this protein?
Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor.  Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.
What are the official names of this protein?
Ribonuclease M5, RNase M5, Ribosomal RNA terminal maturase M5.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease M5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_BACAC
Sequence: MSKTVVRKNESLEDALRRFKRSVSKTGTLAEARKREFYEKPSVKRKKKSEAARKRKF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RL28_TREPA
Sequence: MARRCGLCGKGTISGCAVSKSMHHCKRVWKPNLLAVRVVVDGSALNMRICARCLRSNPLMKKAQPRANAPLRAAAPKL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: CEMA_PIPCE
Sequence: MPKKKALAPPPYLVSIVFLPWWISLSFQKSLEPWITNWWNSRKSETFLNDIQEKGVLEKFIELEELLLLDEITKECPETQIQKLYIGIYKETIQLVKIKNEEHIHIILQISANIICFATLSGYAILCNEELVIVNSWIQEFLYNLSDTIKAFSILLVTDLCIGFHSPHGWELMIGSVYKDFGFAHNEQIISGLVSTFPVILDTILKYWIFHYLNRVSPSLVVIYHSMNE
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
What are the official names of this protein?
Chloroplast envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: RRF_CAMJJ
Sequence: MLNEIFNKQKTQSEKSLEALKKDFTTLRTGKVNIHILDHITVDYYGTQTPLNQVATVLASDASTISITPWEKPLLKTIESAIAAANIGVNPNNDGESVKLFFPPMTREQREENVKQAKAMGEKAKVSIRNIRKDANDAVKKLEKDKAISEDEAKKAYDEVQKLTDTYTTKIDESVKSKESELLKV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY2_BACAN
Sequence: MNILTLILSYLIGSISFALIVGKMFYKKDIRDYGSGNLGATNAYRVLGIKAGVIVAIADILKGTFACLLPLILSSTINPIVCGLLAILGHIFSVFASFKGGKAVATATGVFLFLSPLGVLVGFVVFVLTLLFTKYVSLSSMLAGIALFIYSLIFEDKVIIALSLLIIVSIIILHRQNIKRILNGTENKIV
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 2, Acyl-PO4 G3P acyltransferase 2, Acyl-phosphate--glycerol-3-phosphate acyltransferase 2, G3P acyltransferase 2, GPAT 2, Lysophosphatidic acid synthase 2, LPA synthase 2.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UB2G1_MACFA
Sequence: MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEGRWLPIHTVETIMISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.  May be involved in degradation of muscle-specific proteins.  Mediates polyubiquitination of CYP3A4.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 G1, E2 ubiquitin-conjugating enzyme G1, Ubiquitin carrier protein G1, Ubiquitin-protein ligase G1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: ATPA_BACCQ
Sequence: MSIRAEEISALIKQQIENYQSEIEVSDVGTVIQVGDGIARAHGLDNVMAGELVEFSNGVMGLAQNLEENNVGIIILGPYTEIREGDEVRRTGRIMQVPVGKELIGRVVNPLGQPVDGLGPINTTNTRPIESPAPGVMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTAVALDTIINQKDEDMICIYVAIGQKESTVRNVVETLRKHGALEYTIVVTASASQPAPLLYLAPYAGVTMGEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFIETQAGDVSAYIPTNVISITDGQIFLQSDLFFSGVRPAIDAGTSVSRVGGSAQIKAMSKVSGTLRLDLASYRELEAFAQFGSDLDKATQAKLNRGARTVEVLKQGLHKPLRVEKQVIILYALTRGFLDDIPVVDITRFEEEFHAWLDSNATDLLEEIRTTKKLADDDKFAAAINGFKKVFVASE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HFLX_ALKPO
Sequence: MQDIKQRDIEHVILVGCQVNREDEEFEQSIAELESLAKTAKGKVVGTITQKREKVESSTYVGKGKVQELVHLIEETEADLVIFNDELQASQMRNLHAECGIAVIDRTQLILDIFASRAKSREGKLQVELAQLKYLLPRLSGQGLALSRQGGGIGTRGPGETQLETDRRHIRRRMNEIERQLEAVVNHRVRYREKRKKNAAIQLALVGYTNAGKSTLLNRLTKADTLEEDQLFATLDPTTRQLHLPSGFSVLMSDTVGFIQDLPTTLVASFRSTLEELKEADLLLHVVDCSHPDYEQHERTVIKLIEELEAHSIPQLLIYNKADQKTDVFIPTHTKDSIIMSAYNEEDLLALKVKIEQALKGMMMPYRSIIKADEGHILAAARQETMIHTQQFDESREAYVIEGHALENTSIYSQLKERLLKES
What is the function of this protein?
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
What are the official names of this protein?
GTPase HflX, GTP-binding protein HflX.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=May associate with membranes.
Protein: FOLD_PSEPW
Sequence: MTAHLIDGKAIAANLRKQIAQRVEERRQQGLRTPGLAVILVGTDPASQVYVSHKRKDCEEVGFISQAFDLPSETTQQALTELIDRLNDDPAVDGILLQLPLPAHLDASLLLERIRPDKDVDGFHPYNIGRLAQRIPLLRPCTPKGIMTLLESTGQDLYGMNAVIVGASNIVGRPMAMELLLAGCTVTVCHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWVKEGAIVIDVGINRQEDGKLVGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAEELHK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: KYNU2_ASPTN
Sequence: MSENNCSKPSFPDNAASKEYAASLDAADPLASFRDQFIIPSKANIACKRLAKPNLSPEPCIYFCGNSLGIQPKATAKYLEAQLDTWSSIGVCGHFTNLEDSPMKSWQLLAEQAAESMSKIVGADPAEVAAMGTLTANLHLLMASFYKPTATKHKILMDWKAFPSDHYAIESHIAWHNLDPKESMVLIGPDEGEYEISTDKILSYIDQHAEDAALLLLPGIQYYTGQLFDIPKITEYAKSRNLVVGWDLAHAYGNVELKLHDWNVDFAAWCTYKYGNAGPGAMAGLFVHDKHGQVDYSQGEDSPKFRHRLTGWYGGDRSVRFKMDNKFKPIPGAGGFQISNPSAIDLSCLCAALSVFDQTSVSELRRKSLKLTAYLEYLLLKDTTEDSRPFRIITPTNPEARGAQLSLLLKPGLLQGVSERLQDAGIICDKREPGVVRVAPVPLYNTYSEVWEFVQQFRAALQL
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase 2, Biosynthesis of nicotinic acid protein 5-2, L-kynurenine hydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y818_PYRAE
Sequence: MRVRKPAVAGYFYESGREELLQQIEWAVKHELGPKALQMPKLGGEALGGVAPHAGYMYSGPVAAWLYSALAGYGKPDVFVIVGPNHYGIGAPVAIMKSGAWETPLGRVEVDRELAEVITSHFKEVEDDFYAFSKEHSVEVQVPFIQYYFGDVKIVPIVMWRQTLSTSRELGRAIAKALKEYGRKAYVIASSDFNHYEPHDITTRKDEMAISKILKLDEAGLFEISSKFDISICGIGPIGVLIAAAKELGYINVTLLKHATSGDTSGYKDETVGYASILFYR
What are the official names of this protein?
MEMO1 family protein PAE0818.
What is the protein family that this protein belongs to?
Belongs to the MEMO1 family.
Protein: SURF1_HUMAN
Sequence: MAAVAALQLGLRAAGLGRAPASAAWRSVLRVSPRPGVAWRPSRCGSSAAEASATKAEDDSFLQWVLLLIPVTAFGLGTWQVQRRKWKLNLIAELESRVLAEPVPLPADPMELKNLEYRPVKVRGCFDHSKELYMMPRTMVDPVREAREGGLISSSTQSGAYVVTPFHCTDLGVTILVNRGFVPRKKVNPETRQKGQIEGEVDLIGMVRLTETRQPFVPENNPERNHWHYRDLEAMARITGAEPIFIDANFQSTVPGGPIGGQTRVTLRNEHLQYIVTWYGLSAATSYLWFKKFLRGTPGV
What is the function of this protein?
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
What are the official names of this protein?
Surfeit locus protein 1.
What is the protein family that this protein belongs to?
Belongs to the SURF1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NUON_AZOC5
Sequence: MSSLLPPLGAVLPELLLALSAVVLVLIGAIQGEKSANLVNGLAIAALVAAGVLVMLQPAVTIAGFNGSMLVDPFARFMKVVALLGAAVSLIMSVDWLNRAQQAKFEYAVLVVLASLGICILISAGDLIALYLGLELMSLSLYVVAAINRDSVRSTEAGLKYFVLGALSSGMLLYGASLIYGFTGTVNFAGIAKVATAPTTGLVFGIVFLFAGLCFKVSAVPFHMWTPDVYEGAPTPVTAFFATAPKVAAMAVFVRVAVEALPHVTHSWQQIVTFVSIASMALGAFAAIGQRNIKRLLAYSSIGHMGFALVGLAAGTEQGVTGVLLYMAIYVVMTLGSFTCVLAMRRDGRSVETIEDLAGLARTKPLMALALAALMFSLAGIPPLAGFVAKYYVFLAAIQAGLYGLAVIGVVASVVGAYYYLRVVKIMYFDEPAEAFDGMPGELKAVLAVSGLFTTFFFLAPTPLIAAAGAAARALF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YCIB_ECO45
Sequence: MKQFLDFLPLVVFFAFYKIYDIYAATAALIVATAIVLIYSWVRFRKVEKMALITFVLVVVFGGLTLFFHNDEFIKWKVTVIYALFAGALLVSQWVMKKPLIQRMLGKELTLPQSVWSKLNLAWAVFFILCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGIYIYRHMPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IPO9_DROME
Sequence: MSLQFQNDCGDSVKQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWTDDDDVKRKANGCMASEQAKRTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPHCWAELFDIIVKCLGGNEDSIHGAMQVLQDFSYDVEQIKELGPVVIPEVYRIFDSEQNYSIKTRVSAIRILKPLFASIAALITNKEEQSTMMSSILTNFMDKLMHYLSMNSGAVSSFLLRTEIIKVFTHLVNEMPKYINPFMDRVLPIVWQLLTQIAETYVKVSVNQTETSPLASGDSEEDDEQTNFQSLIIQILEFINCILTCNKLRGSIKNVLADLIYITIVYIQLSEEQLEDWHDDPEKFVDDEDDGGVELTVRMCGRDVLLAINDEFGANAIQPLQEALGRHFSVADAEKAANNPNWWKIQEACMDAVHAFRDVILAGDSTFDLLNYLTIVRNLLVHQESPPLVGRALWTLSIYSKSDLYNPQMLTEILDVTLCSLSPEKSHILRISAVRTLNGFLQANETIDGEKRTLLVSKLPGFLDGIMALVPGSKAAVLALLMEALTFMVKFDAEFAFASQAKITPLAIAVFLKYTEDPYVLETVQDLIKALCQRKECLGPLQEKFIPTIVSILGLTGAASTEKQDIALDVLNTIVRYTEPPLNNSLLETAFPAIINCVLHTDDHAVMVAGGECLRSFINVSPEQICSYKNGEGINCIMQVVATVLLNPMNSEMTAAGQIGRLVITIITKMGSMLGQNVDMLLKAVISKMQNLECLKVIMNLVLIFAHLFLTQMDAVLNFLSTVPGPNGEPAMQFVLTNWLSRQNSFFGNYERKVTTMALCKLFEYGVATQDNRLTTITFKELVDDPTDTRRRTRSVAATTQKWVTIPALVKIFKVLISEYQHFQEGKSDEPLTDSEEDGDDEDAPGNPDKPRYISDLFESDEDNAEDEQLLQELLKETNYQGDIADNLQKFLTTFTQNEHFPTFYEHLTEGERLILLSKVQQK
What is the function of this protein?
Nuclear transport receptor that mediates nuclear import of proteins (PubMed:33632744).  Serves as receptor for nuclear localization signals (NLS) in cargo substrates (By similarity).  Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (By similarity).  Mediates the import of pre-assembled proteasomes into the nucleus during the late stages of sperm development (PubMed:33632744).
What are the official names of this protein?
Importin-9, Ran-binding protein 9.
What is the protein family that this protein belongs to?
Belongs to the importin beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RLMH_ALKOO
Sequence: MNITIISVGKLKEKYLKLGIDEYIKRLTRYAKLNIIEIPDEKAPENLSSAEEQIVKNKEGEGILKNIKDGMYVIALDLKGKMLSSEELADKLQSLGVAGNSNIAFIIGGSLGLSEDVLKRADYKLCFSPMTFPHQLMKLILLEQIYRGLRIIKGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_PHOPR
Sequence: MIGLIGRKVGMTRIFTEEGISIPVTVVEVEANRVTQVKSLETDGYNAIQITTGTKKANRVSKPAAGHFAKAGVEAGRGLWEFRLENGEEFAVGAELNVELFNEVKKVDVTGTSKGKGFQGVIKRWNFSTQDMTHGNSLSHRAPGSIGQCQTPGRVFKGKKMAGHMGAERVTTQNLEIVRVDAERNLLLIKGAVPGSIGGNVIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ACHA3_MOUSE
Sequence: MGVVLPPPPLSMLMLVLMLLPVASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSTEEDAPKTRNFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMARDDT
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-3.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RLMN_LEPIN
Sequence: MISENLGENQTEKIPLKGRTLKELSEIMITLGEKPFRAKQIYHGLYVNRYETWDQFTTFSKIFKEKLEELCSLTHLQVVKQLKSVDGTQKFTFTSESGNGKEFEAVWIPSGDGGRKTICISSQIGCTLNCKFCATAKLEFQGNLKAHEIVDQILQVEKIVGDKATNVVFMGMGEPLHNYFNVIRAASIFHDPDAFNLGAKRITISTSGVVNGIRRFIENKEPYNFAISLNHPDPKGRLQIMDIEEKFSLPELLQAAKDFTRELKRRITFEYVMIPGVNMGFENANKLVKIAKSLDCKINVIPLNTEFFGWRRPTREEIAEFIALLEPAGVPILNRRSPGKDIFGACGMLASKS
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_NOCFA
Sequence: MGAAATGTPLRIGTRGSLLAMTQAGTVRDALIAAGRPAELVVVKTPGDMSSDPVQKIGVGVFTSALRDELAAGTIDLAVHSYKDLPTAPDPRFVIAAIPPREDPRDALVARDGLVLGELPAGAKVGTSAPRRVAQLRALGLGLDIVPLRGNLDSRLARVTDGELDAVVVARAGLSRIGRTAVITEALEPVQMLPAPAQGALAVECRSEDAALIEALAELDDAATRAAVVAERALLAELEAGCTAPVGALAEVVESLDDDGRIVEELSLRGCAAAVDGSEVLRASVVGDPERAAELGRALARELLELGARELLVEVAATEPGARSGTGAVRPPETDLSNPSPMENPQ
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: LAP_LSDV
Sequence: MEGSDNTNTHCWICKDEYNVSTNFCNCKNEFKIVHKNCLEEWINFSHNTKCKICNGKYNIKKNKKSCLRWKCSFMYCNVPAICVSLICLLLLPLTILLVKFNLKSMLENIENRDLIALISAMAYSLPCVVGFITVVHILIALYDYYLAAKSDNTTYQVYEYI
What is the function of this protein?
E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.  Binds target molecules through transmembrane interaction.  The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase LAP, Leukemia associated protein, LAP, RING-type E3 ubiquitin transferase LAP.
What is the protein family that this protein belongs to?
Belongs to the poxviridae LAP protein family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network membrane. Host early endosome membrane.
Protein: RL22_MARN8
Sequence: MEVAAKYKGARLSAQKARLVADQVRGKAVEDALNILTFSPKKAAVVIKKALESAIANAEHNEGLDVDDLRVSTVMVDEGPTLKRIKARAKGRADRIFKRTCHITVKVADK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: TEAA_HALED
Sequence: MKAYKLLTTASIGALMLGMSTAAYSDNWRYAHEEYEGDVQDVFAQAFKGYVEDNSDHTVQVYRFGELGESDDIMEQTQNGILQFVNQSPGFTGSLIPSAQIFFIPYLMPTDMDTVLEFFDESKAINEMFPKLYAEHGLELLKMYPEGEMVVTADEPITSPEDFDNKKIRTMTNPLLAETYKAFGATPTPLPWGEVYGGLQTGIIDGQENPIFWIESGGLYEVSPNLTFTSHGWFTTAMMANQDFYEGLSEEDQQLVQDAADAAYDHTIEHIKGLSEESLEKIKAASDEVTVTRLNDEQIQAFKERAPQVEEKFIEMTGEQGQELLDQFKADLKAVQSESEG
What is the function of this protein?
Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock.  Probably functions as a recovery system for synthesized ectoine that leaks out of the cell.  Binds ectoine with high affinity.  Affinity for hydroxyectoine is approximately 20-fold lower.
What are the official names of this protein?
Ectoine-binding periplasmic protein TeaA.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 7 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS15_DEHMC
Sequence: MDKQEKSLIINEFKKSESDTGSTEVQVALLTARIHQLTTHMIANKHDFHTKRSLLTLVGRRRRLLSYMRNSNGAGYQELIANLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.