PharMolix/UniProtQA huggingface dataset:
Protein: WDR1B_XENLA
Sequence: MPYEIKKVFASLPQVERGVAKIIAGDPKGNNFLYTNGKSVIIRNIDNPAIADIYTEHAHQVVVARYAPSGFYIASGDTSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGSVFLWDTGSSVGEIIGNIKVINSVDIKQTRPYRLVTGSDDNCCAFFEGPPFKFKFTMSDHSRFVNCVRFSPDGSRLASAGADGQIFLYDGKTGEKVCSLGGSKAHDGGIYAVSWSPDGTQLLSASGDKTAKIWDVAANSAVTTFNLGSDVLDQQLGCLWQKDYLLSVSLSGYINYLDKNNPAKPFRIIKGHNKSIQCMTVDKSDGRSTIYTGSHDGHINYWDAETGENNTFTGKGHTNQVSSMDLDGSSQLITCSMDDTLRYTNLISKDYSSSESVKMDVQPKCVAVGSGGYVVTVCIGQIVLLKDKKKVFAIDSLDYEPEAVAIHKGSGTVSVGGADGKVHLYSIQGNSLKDEGKTLPAKGAVTDLAYSPDGAFLAVTDANKVVTVFSVADGYSEHNSYYGHHAKALSVAWSPDNEHFASSGMDMMVYVWTLSDPDTRIKMPDAHRLHHVSSLAWLDENTLATVSHDACVKQWTVTFK
What is the function of this protein?
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins.  Doesn't sever actin filaments alone, but caps the barbed ends of filaments severed by cofilin, which blocks annealing and depolymerization and allows more extensive severing by cofilin (By similarity).
What are the official names of this protein?
WD repeat-containing protein 1-B, Actin-interacting protein 1-B, xAIP1-B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat AIP1 family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm, cytoskeleton. Nucleus.
Protein: RS16_ACIAD
Sequence: MVVIRLARGGAKKRPFYQIVVTDSRNARDGRFIERIGFFNPTAQGQAEKLRLDADRFAHWVSQGAQPSERVASLAAQAKKAATAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SYL_CAMJE
Sequence: MAYEASLIEKKWQKIWDENEYFEPKDDLNLPKKYILSMFPYPSGRIHMGHVRNYTIGDALARYYRKIGFNVLHPIGFDSFGMPAENAAIKHKIHPKSWTYENIAYMKKELFSLGFSFSKKRMLATSDPLYTKFEQEFFIKMFEKGLIYTKEANVNWCEQDQTVLANEQVEDGKCWRCGHEVVQKKMPGYYVKITAYAEELLKDLEELKDKWPNQVLTMQENWIGKSEGLEFSLNLDEESKQKTKESSLEVFTTRADTIYGVSYIALAPEHKIVQNLLSQNLLNQDVLNKIKVIQNQSPRERQSSEKEGYFLGIYAIHPLSGEKIPLWVANFVLADYGSGAVMAVPAHDERDFEFATKYNLAIKQVIQTQENLPYMQKLGKLINSQEFDNLDCNEARLKIISQFEAKNIGKRVVNFKIRDWGVSRQRYWGAPIPMIKCQSCGIVPQKLENLPITLPEDVQITGEGNPLDKHPTWKNCICPKCGKEAQKESDTLDTFFESSWYFARFASDEKTWQEKALDEKSVKYWMSVDQYIGGIEHAILHLLYARFFQKALRDLGYLTQNEPFDRLLTQGMVLKDGAKMSKSKGNVVDPDEIIEKYGADTARLFILFAAPPAKELEWNDDAVEGAYRFICKLYDRAQNVKKGELVELKQENLNKEEKYARLKVYEALKKSFEVYHQSFAFNTLIAACMEALNALALCKNEALEQEAFYIILNILEPIIPHVCFELSEELFKCKNFKKLELKEEVFVKDTLNLAVSINGKKRAEFEISSSASKEEILAFAKENTAKWLEGKSIVKEIYVEGKLVNLVIK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETA_PSE14
Sequence: MTTQSEYDYIIIGAGSAGNTLAARLTEDAGVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGRRYNWAYETEPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDYDGWAKEPGLEDWSYLDCLPYFRKAETRDIGPNDYHGGEGPVSVTKPKAGNNPLFHAMVEAGVQAGFPRTDDLNGYQQEGFGPMDRTVTPNGRRASTARGYLDEAKKRSTLTIVTHALTDRILFEGKRAVGVAYLVGDSDTRIQARARKEVLLCGGAIASPQILQRSGVGPAEVLNKLDIPVVHDLPGVGQNLQDHLEMYLQYACTQPVSLYPSLKWWNQPAIGAKWMFLGTGIGASNQFEAGGFIRSSEAFEWPNIQYHFLPVAINYNGTKGVQEHGFQAHVGSMRSPSRGRVQVKSKDPREYPSILFNYMSSEQDWQEFRDGIRLTREIMQQPALDPYRGREISPGIDVQSDEALDQFVREHAETAYHPSCSCKMGTDEMAVVDGQGRVHGLQSLRVVDASIMPIITTGNLNAPTIMIAEKIADKIRGRQPLPRSTADYFVAGDKPARGKPLREISHQA
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: SYL_SINFN
Sequence: MATERYNPRDTEPRWQQEWDARKVFETENDDPREKYYVLEMFPYPSGRIHMGHVRNYTMGDVVARYKRARGFNVLHPMGWDAFGMPAENAAMERGVHPAGWTYQNIAAMKAQLKVMGLSLDWSREFATCDPAYYQRQQYLFLDFLEKGLVYRRQSKVNWDPVDNTVLANEQVIDGRGWRSGALVEQRELTQWFFRITDFSQDLLDALDGLEQWPEKVRLMQKNWIGRSEGLALRWALDPATVPGETKELTVYTTRPDTLFGASFLAISADHPLAREAAAKDAAIDAFCEECRRAGTSLAALETAEKKGIDTGIRARHPFDPEWELPVYVANFVLMDYGTGAIFGCPSGDQRDLDFARKYGLSVVPVVMPKDADAATFTIEDEAYGGDGVMINSRFLDGLSTEEAFEAVASKLEQETLDGAPRAERKVNFRLRDWGISRQRYWGCPIPVIHCEDCGVVPVPKADLPVTLPPDVTFDKPGNPLDRHPTWRHVACPQCGKDARRETDTMDTFVDSSWYYARFTAPWEDKPTDPKAANHWLPVDQYIGGIEHAILHLLYSRFFTRAMKATGHVAMDEPFKGLFTQGMVVHETYSRGEGAQREWVTPAEIRIDEIDGRRRAVLIETGEEVAIGSIEKMSKSKKNVVDPDDIIGSYGADTARFFVLSDSPPDRDVIWSEAGVEGAHRFVQRVWRLVGEAAESLRGAKASPAKEGEGLAISQAAHRTLRAVEADYDKLAFNKAVARIYELVNVLAAPLTQVAAGKADQAVTAAVKDATTILIDLIAPMMPHLAEECWREIGGEGLIAERPWPTFDPALVVENEITLPVQINGKKRADLTIARDADQSAIESAVLALDAVKAALNGASPRKIIVVPQRIVNVVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_SYNFM
Sequence: MRVIVVNSGSSSIKYEVFALDDCSTLVDGLLERIGTRNARFKRRWLTDSGHWEEMEETRPIADHHEGFRFLLDAAVRYPTTRVAPGAFFGFGHRVVHGGEVFHEPVIVDDEVVRRIKDLIPLAPLHNPANVAAIEALRLIRPDVPNVAVFDTAFHQSMPPKAFLYALPHELYREHHVRRYGFHGTSHRYVAGEAARHLGLPEDYANLITLHLGNGASATAVQGGRSIDTSMGLTPLEGLIMGTRCGDLDPAVHFYISRKTGRSSEELEAMMNKESGLKGICGTNDMREIQRRSADGDARAQLAFEMFCYRIRKYIGSYSAALGRVDAIVFTGGIGENSAPVRRECCDGLRNLGVVLDHRRNEEDWSGLHEIQREDSPVKILVIPTDEEREIARQTIQTIRRAGVAGGARNQ
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP404_ARATH
Sequence: MVNLLSANREALIAQSICATVLKGNWKNILKHKVDSGLLKSAITTQVISELSLFSGYGGPSLSWSFFIWTDSLPSSKHSLQSSWKMILILTKHKHFKTAHQLLDKLAQRELLSSPLVLRSLVGGVSEDPEDVSHVFSWLMIYYAKAGMINDSIVVFEQIRSCGLKPHLQACTVLLNSLVKQRLTDTVWKIFKKMVKLGVVANIHVYNVLVHACSKSGDPEKAEKLLSEMEEKGVFPDIFTYNTLISVYCKKSMHFEALSVQDRMERSGVAPNIVTYNSFIHGFSREGRMREATRLFREIKDDVTANHVTYTTLIDGYCRMNDIDEALRLREVMESRGFSPGVVTYNSILRKLCEDGRIREANRLLTEMSGKKIEPDNITCNTLINAYCKIEDMVSAVKVKKKMIESGLKLDMYSYKALIHGFCKVLELENAKEELFSMIEKGFSPGYATYSWLVDGFYNQNKQDEITKLLEEFEKRGLCADVALYRGLIRRICKLEQVDYAKVLFESMEKKGLVGDSVIFTTMAYAYWRTGKVTEASALFDVMYNRRLMVNLKLYKSISASYAGDNDVLRFFWSHVGDRCLISKSILREMNRSEVL
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At5g38730.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: MMS19_DANRE
Sequence: MAADNNVLLGLVEEFVSGQVDSKAADTSTGVKNGQFTVLQLVEALGVSLTSSQPQTRGRGVQLLSQVLQECYSGLSEREVEVLIAFYENRLKDHYVITPHVLRGLKALAKCSVLPPGSAVSILKSIFQDVHVQQQSLMVTERSCVYNILISLMESREEELKGLGADFIFGFVQSVDGERDPRNLLLAFQVAKNIIYRGYDLGKFVEELFEVTSCYFPIDFSPPPNDPHGITQEELILSLRAVLTGTPRFAEFLLPLIIEKMDSDVQSAKVDSMHTLAACGQTYSHKELAEFLPGLWSSIRREVFQTASERVESAGLSALSSLVSCLSRSVLNSDSEDSLQVFLNLVLKSDCQHHLCEPDLKLVWPSAKLLQAAAGASYRASLIGTQAVIPALLDQYNNRTQCAQRRTLLEVLQGFVQPTPLSRPADGVSCISTHTHEEESVLVAFQQSLCTVVFSALSETSAGLQVTATRVLTALSQQPGLLSQTDVENAVDHLTRLILEEEEAQVSLAVVECSGSLAHLHPHAFVSRMIPQLKEKILSGRVHTVMEKTLSGSLYECSGAVRRRCVAALASVSSQPSVVQESSPVLLQVLTSAHTGCCGFSVEEVIAVCISLQRIAVHARDNEAIGQFFHDIIIPRLLGLTLQAALQSKDSGHISPLTDEAVLSAIVPVISTACAALKPESASRMAAQAVSLFLDGDTSFLPENAFPSQIQPLQSQADSRGPSQLVCLLMACVCSLPRSVEIPDMDRLLVQLEDLSCTSPHLFSYTFASKCIAGLVNKRPAGAALNAVLDRVLKRVSLELEETSSTHRTQAFTLLIWVAKALLLRYHPLSTALTDKLFSLLSDSALGSLVADGFCVLMNDSPDVLNRDCHADVRIMYRQRFFTENSSKLVQGFNSAEQAKKSCYLKALSHIVNNLPREVQLTELPALLPLLLEALSCVDQGVQLSTLSCLQPVLLESPAALNTQLEALFTRLLALTTSPAMKVRMASLRCVHALSRLPEHMVMPFRARVLKALAAPLDDKKRLVRKEAVAARGEWFLLGSPGG
What is the function of this protein?
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity.  In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity).
What are the official names of this protein?
MMS19 nucleotide excision repair protein homolog, MMS19-like protein.
What is the protein family that this protein belongs to?
Belongs to the MET18/MMS19 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle.
Protein: RNY_STAES
Sequence: MNLLSLLLILLGIILGVVVGYIVARNLLHQKQVQARQTADDIVSYANKEADNIKKEKLLEAKEENQILKEQAENELRERRGELQRQETRLLQKEENLDRKSDLLDKKDEILEQKESKLEERQQQVDAKESSVQTLIMKHEQELERISGLTQEEAVKEQLQRVEEELSQDIAILVKEKEKEAKEKVDKTAKELLATTVQRLAAEHTTESTVSVVNLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRREIARTALVNLVSDGRIHPGRIEDMVEKARKEVDDIIRDAGEQATFEINVHNMHPDLVKILGRLNYRTSYGQNVLKHSIEVAHLSGMLAAELGEDVTLAKRAGLLHDVGKAIDHEVEGSHVEIGVELAKKYNENNIIINAIHSHHGDVEPTSIISILVAAADALSAARPGARKETLENYIRRLERLETLSESYDGVEKAFAIQAGREIRVVVSPEEIDDLKSYRLARDIKNQIEEELQYPGHIKVTVVRETRAIEYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: APOA2_COLAN
Sequence: MKLLAATVLLLTICSLEGALVRRQAEEPSVESLVSQYFQTVTDYGKDLMEKVKSPELQAQAKAYFEKSKEQLTPLVKKAGTDLVNFLSYFVELRTQPATQ
What is the function of this protein?
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
What are the official names of this protein?
Apolipoprotein A-II, Apo-AII, ApoA-II, Apolipoprotein A2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RK21_HUPLU
Sequence: MNAYAVIETGGEQLRVEPGRFYDVRHFASLNPENLGPNSKILIYRVLMICDESTINIGHPWLKGAMIKGRILHSRLDNKITVYRMRSKKKTRRKLGHRQKLIRFVVDSICSDVKDLYKQKD
What is the function of this protein?
This protein binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L21, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: OGT_THEKO
Sequence: MLSVEKFRVGERVVWIGVIFSGRVQGIAFAFDRGTLMKRIHDLAEHLGKRGVSISLDVQPSDYPEKVFKVLIGELDNASFLRELSFEGVTPFEKKVYEWLTKNVKRGSVITYGDLAKALNTSPRAVGGAMKRNPYPIVVPCHRVVAHDGIGYYSSGIEEKKFLLEIEGVKEWTS
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase, Pk-MGMT.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_TROWT
Sequence: MITKVSGFLFRTFREDPATTESRGYGFLLRAGYIRQTGSGIFSWMPLGLKVRHKIENIIRYEMGQVNAIEVLFPALFSADLFKQSGRWSEYGDDIFRLKDRRQGDYLLAPTHEEAFTQMMKEICTSYRDLPRTVYQIQDKYRDELRPRAGLLRSREFSMKDAYSFDLDEKGLRQSYEAQKRAYKKIFDRLKIDYVIVKANAGAMGGSVSEEFLHPTEMGDDTFVVTADGSAFNAEVYVTPPGPAIDYSNAPEAEDCETPGVISIPDLVNHMNSSGRFIGRVIESSDCLKCLLFRIEYAEVQNGNPSNLVVKKILERGFEYIGFLVPGDRNVDLKRAQVALSPLTIEPADNRVFECNPSFVRGSIGPGLSGVFYCADPRVSLGSSWIIGANRPGVHRIGAIAGRDFSFDCTLDVSSIKTGDKSEWGPVTVKRGIEIGHLFQLGLKYSNALGLKVLDKDGYNKAVFMGSYGIGVSRLFALIAEKNCDERGLKWPAVLAPFDLHVVLLSSARAELIDSLTDCGLDVLVDDRRVSPGVKFTDAQLIGVPKIIVIGDKTRGEDVEVWDRANDQRTVLPLKEMIQGVIQGVIQGVIQGVIQGGDTGGDTGGDTGGCTER
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIG1A_RAT
Sequence: MSTNTDLSLSSYDEGQGSKFIRKARETPFVPIGMAGFAAIVAYGLYKLKSRGNTKMSIHLIHMRVAAQGFVVGAMTLGMGYSMYQEFWAKRKP
What is the function of this protein?
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water.  May play a role in the assembly of respiratory supercomplexes (By similarity).
What are the official names of this protein?
HIG1 domain family member 1A, mitochondrial, Hypoxia-inducible gene 1 protein.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane.
Protein: RL30_HAES1
Sequence: MAKTIKVTQVRSSIARLPKHKATLRGLGLRRINHTVELIDTPAIRGMINQVSYMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: VITF3_VACCW
Sequence: MDNLFTFLHEIEDRYARTIFNFHLISCDEIGDIYGLMKERISSEDMFDNIVYNKDIHPAIKKLVYCDIQLTKHIINQNTYPVFNDSSQVKCCHYFDINSDNSNISSRTVEIFEREKSSLVSYIKTTNKKRKVNYGEIKKTVHGGTNANYFSGKKSDEYLSTTVRSNINQPWIKTISKRMRVDIINHSIVTRGKSSILQTIEIIFTNRTCVKIFKDSTMHIILSKDKDEKGCIHMIDKLFYVYYNLFLLFEDIIQNEYFKEVANVVNHVLTATALDEKLFLIKKMAEHDVYGVSNFKIGMFNLTFIKSLDHTVFPSLLDEDSKIKFFKGKKLNIVALRSLEDCINYVTKSENMIEMMKERSTILNSIDIETESVDRLKELLLK
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from intermediate gene promoters.
What are the official names of this protein?
Intermediate transcription factor 3 large subunit, VITF-3.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG150 family.
Protein: UVRB_BACCR
Sequence: MERQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPTLVMAHNKTLAGQLYSELKDFFPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEIDKLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVSLRVGMEKDRNQLLRELVDVQYGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAEREHVAIFPASHFVTREEKMKVAIENIEKELEERLKELNENGKLLEAQRIEQRTRYDLEMMREMGFCSGIENYSRHLTLRPAGATPYTLLDYFPKDFLIVMDESHVSVPQVRAMYNGDQARKQVLVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYELEQSPEVIEQIIRPTGLLDPPIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVTYLHSEIKTLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNENGRVIMYADRITKSMGIAIEETKRRRSIQEAYNEEHGITPKTIQKGVRDVIRATTAAEEIETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALDFERAAELRDLLLELKAEG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y241_ATV
Sequence: MDKDELKEIIKNLPDNSPKILEYLKLAKEKGWKDIVNMIAQKLGLEEEEKKKTDETDVLKKILKPLGKGKIKGTWDYSVDFVEAKKTLVSAYKQLYDTNLMPYEAYVAILLIQLVNGCRIREAIRAFKTFIESGEREFQLQAQKHGNIRFMIIPDVVKKKATYNAVLTIDDEKLSARIRMFALHYLKANTHSLRYALISYLAKNGIDPAIIAKITGHKRLDRIITYTQTKDAIEMLRKLAD
What is the function of this protein?
This protein may encode an integrase, which is necessary for integration of the viral DNA into host genome.
What are the official names of this protein?
Putative integrase ORF241.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: RNH_THEP3
Sequence: MSNNIDVVEIYTDGACSGNPGPGGWAAVLLYKGTKKEISGFEENTTNNRMELKAVIEGLKALKRPCKVNLYSDSSYVINAFKEGWLEKWQKNNWLKSDKTPVENQDLWKELLEISKNHQVNWIKVKGHADNEYNNLCDRLATEQIKRNTRQNPKE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_RICCN
Sequence: MALKNFNPITPSLRELVQVDKTSLWKGRPLKSLTKGISKTGGRNNQGRITSWHRGGGHKKLYRIIDFKRNKIDISAIVERIEYDPNRTAFIALIKYEDGEYSYILAPQKLSVGDRVISSQDADIKIGNCLPLKCIPIGTTLHNVEMKVGKGGQIARSAGTSVDLVGKDSGYAQIKLRSGEFRLVPLDCKATIGSISNPDQKNINLGKAGRNRWLGWRPHVRGVAMNPVDHPHGGGEGKTSGGRHPVTPWGFPTKGKKTRKNKRTSKFIVKKRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: TYSY_BPT4
Sequence: MKQYQDLIKDIFENGYETDDRTGTGTIALFGSKLRWDLTKGFPAVTTKKLAWKACIAELIWFLSGSTNVNDLRLIQHDSLIQGKTVWDENYENQAKDLGYHSGELGPIYGKQWRDFGGVDQIIEVIDRIKKLPNDRRQIVSAWNPAELKYMALPPCHMFYQFNVRNGYLDLQWYQRSVDVFLGLPFNIASYATLVHIVAKMCNLIPGDLIFSGGNTHIYMNHVEQCKEILRREPKELCELVISGLPYKFRYLSTKEQLKYVLKLRPKDFVLNNYVSHPPIKGKMAV
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family.
Protein: IMFS_LUFAE
Sequence: MWRLKVADGGNDPYIYSMNNFIGRQIWEFDPNAGTPEERAEIERLRHHFTKNRHKGFPSADLLWRVQLLREKNFKQSIPAVKVGDGEEISYEMALDAMRRGAHFLAAIQASDGHWPSETSGPLFYVCPLLICMYIMGFMDKVFSPEHKKEMMRYIYNHQNEDGGWGLHVGGHSNMFCTTFNYISLRLLGEEPDVEAVCKARNWIHDHDGVTSILSWGKTWLSILNVFDWSASNPMPPEYWMLPTWVPIHPSNMMCYTRITYMPMSYLYGKRFQAPLTPLVLQLRDELHTQPYDQINWRKVRHMCATEDLYFPHPFVQDLLWDTLYLLSEPLMTRWPFNKLIRQKALNETMRHIHYEDENSRYITIGCVEKPLCMLACWVEDPNSEYVKKHLARIPDYLWMAEDGMKMQSFGSQSWDAALAMQALLSCNITREIGSVLNSGHDFIKNSQVRNNPPGDYKSMFRYMSKGSWTFSDCDHGWQVSDCTAENLKCCLLLSLLPPDIVGEKMEPERFYDAVNVILNMQSKNGGLPAWEPASSYYWMEWLNPVEFLEDLIIEHQHVECTSSALQAILLFRKQYPGHRRKEINNFINKAVQFLQDIQLPDGSWYGNWGICYTYGTWFALKALSMAGKTYENCEAVRKGANFLRKIQNPEGGFGESYLSCPYKRYIPLDGKRSNLVQTAWGMMGLICAGQADVDPTPIHRAAKLLINSQTEDGDFPQEEITGEFFKNCTLHFAAFREVFPVMALGEYCNKVPLPSKKK
What is the function of this protein?
Oxidosqualene cyclase involved in the biosynthesis of bryonolic acid.  Converts oxidosqualene to isomultiflorenol.
What are the official names of this protein?
Isomultiflorenol synthase, LcIMS1.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
Protein: KAX16_MESMA
Sequence: MKISFLLLLAIVICSIGWTEAQFTNVSCSASSQCWPVCKKLFGTYRGKCMNSKCRCYS
What is the function of this protein?
Potent blocker of both large-conductance calcium-activated potassium channels (KCa1. 1/KCNMA1) and voltage-gated potassium channels (Kv1. 3/KCNA3 and ERG1/Kv11. 1/KCNH2).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 1.6, BmTX2, Neurotoxin TX2.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRUB_METM7
Sequence: MELIVKEESKTDYNYGSDPYKRDIKTLLNTGLVVIDKPSGPTSHEVAAWVRNMLNLVKAGHGGTLDPKVTGALPVALGNTTKCVPIWHIPPKEYVCLMHLHDDAKLEDIENIFKEFTGRIHQRPPLKAAVKRSLRIRKIYEIEILEIDGRDILFRTKCQSGTYLRKLVDDMGEALGTSAHMQELRRTISGPFYENEAVYLQDLLDAYIFWKEDGNEEELRKLVKPLEYGLQHLKKIIVKDSAVDAVCHGATLYSSGVSKIEKGIGTDEVVLIETLKGEAVAVGKPLMNTKDMLKTEEGEVVEITRVIMEPGIYPRIWKKRNKNDKTKAESKKK
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
Protein: ATPB_BRUAB
Sequence: MAKAATPKTTAAAEAKPAAKAPAKKAAPKTTAAAKPAATKSGAPKAAAAGAIGHITQVIGAVVDVKFPEGQLPLILNALEVDNQGHRLVLEVAQHLGEDTVRTIAMDATEGLVRGQEARDTGEPIMVPVGVETLGRIMNVIGEPVDEAGPIKTKATRAIHQNAPEYIEQSTEAEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVNKLGGGEGSKAALVYGQMNEPPGARARVALSGLTVAENFRDQGQDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGAMQERITTTTKGSITSVQAIYVPADDLTDPAPATSFAHLDATTVLSRSIAEKGIYPAVDPLDSTSRMIDPKVVGEEHYAVARQVQSILQRYKALQDIIAILGMDELSEEDKLTVARARKIERFLSQPFFVAEVFTGSPGKLVDLADTIKGFKGLCAGDYDHLPEAAFYMVGSIEEALEKAKKLAAEAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BAALC_RAT
Sequence: MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDALPSAAATDSGPEAGGLHAGVLEDGPSSNGVLRPAAPGGIANPEKKMNCGTQCPNSQSLSSGPLTQKQNGLWTTEAKRDAKRMSAREVAISVTENIRQMDRSKRVTKNCIN
What is the function of this protein?
May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A.
What are the official names of this protein?
Brain and acute leukemia cytoplasmic protein.
What are the subcellular locations of this protein?
Cytoplasm. Synapse, synaptosome. Membrane raft. Postsynaptic density. Note=In neurons, localizes to postsynaptic lipid rafts (PubMed:15659234). In myocardial and skeletal muscle cells, localizes to the cytoplasm adjacent to the inner cell membrane, polarized to one end of the myocyte (By similarity).