PharMolix/UniProtQA huggingface dataset:
Protein: ATP6_LEGPA
Sequence: MGEEGFLAHFAFSIGGLPITQSVLTTWFIMISLFIMAWSTTYKCSLLQPSTYQLIWEGVLSTMYDAIKEVLPDHVELIFPFVATLWIFILVSNLIGVIPGFYSPTADLSVTASLAIMTFLSVHWFGIRAEGWREYLKHYIKPTPFLLPFHLISEISRTLALAVRLFGNIMSLQLTALIVLMIAGFLVPIPILILHIIEAIIQAYIFGMLALIYIAGGIQAHELKSQGESL
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUVA_PSEAB
Sequence: MIGRLRGTLAEKQPPHLILDVNGVGYEVEVPMTTLYRLPSVGEPVTLHTHLVVREDAHLLYGFAEKRERELFRELIRLNGVGPKLALALMSGLEVDELVRCVQAQDTSTLVKIPGVGKKTAERLLVELKDRFKAWENMPTIAPLVMEPRASATVSSAEADAVSALIALGFKPQEASRAVAAVPGEDLSSEEMIRQALKGMV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: SYN_BACSU
Sequence: MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQGVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYPITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGSAPEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIEFWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPRITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPASDREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGSVPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CO9_RABIT
Sequence: MAASHSFAFVVCVLEIGALTAGPTPSYVHEPIQRSDPLQPIDCRMSPWSEWSHCDPCLRQMFRSRSIEVFGQFHGKSCVDALGDRRACIPTEACEDAEEDCEKDEFHCGTGRCIKRRLLCNGDNDCGDFSDEDDCETEPRLTCRNREVQESELARTAGYGINILGMDPLATPFDNEYYHGLCDRVWDGNTLTHYRKPWNVAVLAYETKIDKNFRTEYYEEQMQAFKSIIEEETSNFNANLALKFTPTEAKASKAEEASPKNKSLDDNDKGFSSKFQFSYSKNETYQLFLSYSSQKEKMFLLVKGIIQLGRFVMKNRGVMLTNTFLDDIKSLPTTYEKGEYFAFLETYGTHYSSSGSLGGRYELIYVLDKASMKEKGIELNDIKKCLGFDLDLSLNIPGKSAGLSLTGQANKNNCLKSGHGNAVNITRANLIDDVISLIRGGTQKFAFELKEKLLTKAKMVDVTDFINWASSLSDAPVLINQKLSPIYNLIPVKIKDAHQKRQNLERGIEDYINEFSTKKCSPCQNGGTALLMDGQCLCTCPFMFEGIACEISKRKLA
What is the function of this protein?
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.  C9 is the pore-forming subunit of the MAC.
What are the official names of this protein?
Complement component C9.
What is the protein family that this protein belongs to?
Belongs to the complement C6/C7/C8/C9 family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
Protein: VG65_ICHVA
Sequence: MEINAAIESLTSITDLDPTAVCDDHPNIYLRATMDGALGVMSHIKPVLSETVTTALEDDTVVSSRYAIVTAPPRYKIVEQPYTDADKGYLRGLRTPEACIMYMHYINKIISHAPANPLVRDAVQSMNLNLGLHRDMILGSYSVDDIYTRLDPVAPQIVLGGALYRILHSRNALYPKCAIGVVGPFNQWVDTAQPAGPCATPEVNDILNVAREYELPQRVVADLLIEWVLETSVPIPRGTRNRITLELQKALATHLPAGLFHDIVIVGLGIGLPPRAVSGLEEKMGIDLFWKTQNSYHGRDSVSFRGALENAAVRDCSVITSATGKTAPVTTFGLVTVRTNPPFPKLSKLVTYAPHPPITRSPFLCARVRDVYDQEIEVPHGRASGPRHFSPRMVVLRERAASVPVLTNTLHEHSFSRGYFIPIFLREYKSIYAFWSTLGLPSRSHPLYIFHVLSRSNIRTLETIPDPVPFHPKERVFMGQCLAFYVRETGEELYALKIFRLVMERGVLPMYARGDSAPVQILGFIVNICAALLAFDDTDGLDSLDMDTYDELSALGRVVWYVWLLTTLFPLYMTTATEPEFLDPMFEGTYRLGEWNYVTTTGALYPGDNIERLSVSVDYGALDEKTKGFGETLNIPVHVIGIVNQFIFPILSAQLPYAFRRLPNKSVVRHPIDMIEAVRRKLSERFGSCVNPPYVGPITPSASVPTGKYIHVMKHPEAYPEYTVEASNGTDGDSLSDDSDDESAEPTSTPASWIGDRDEKVRLEARLREMEATVRNDLLIGGRFTHTGPPVIRQPVPRAFPKVDVSLMAEAEKRSGDMLKRLDDVYDLVAKTTHMVETGGMFPVTDLETLPPPPADLLQTSVDSESRSIAPGADPVSHDLDKLDLPPAAYEEPDLPLDLPPAAYEELDLPLDLPPGAYEEPDLPRDLPPGAYEEPDLPPDLPRDLPPAAYEEPDLPPDLPRDLPPAAYEEPAPRAESSEDSTGTTGADGSLPVVSPPEPMSAPGGEPATGTTGVRGFKSERLILPRKIMSSIPRPSDALKERLSTRRTQMYDSGSDSESDSSEYDNSDSDDGRTERATSSTLDDEVERMTHSFNEWVRISTNPVATISDIPPALDPPSDSIGSPGEGAAEEVQLGADPGGDHTRAPPVADLRGAELDRYLYKESESLISVIDELFTEYVTTPAAPPSGPVVTPPVADNGGTRETHPREKCPYTVAEKYRILYTYGEQDELAALVESTGAGTDVERRVSARVLANVPVSSAVIINESLEEDQFTRLENTLYSMGLKRVYIPGDGNCLYNTLRFIAGADGESAIDFKKELLDDIRKYVRNQDPAERDLILTEIDNLAGPNVYGSGDLISFFQLLRGVGVTVVSWDKIGGRLVKLVATNQEGIPPEYIILFTNSHYEPLVTEDTMIPDSYLKDFIEWKRSLFLSAII
What are the official names of this protein?
Uncharacterized protein ORF65.
Protein: MAD2_SCHPO
Sequence: MSSVPIRTNFSLKGSSKLVSEFFEYAVNSILFQRGIYPAEDFKVVRKYGLNMLVSVDEEVKTYIRKIVSQLHKWMFAKKIQKLILVITSKCSGEDLERWQFNVEMVDTADQFQNIGNKEDELRVQKEIQALIRQITATVTFLPQLEEQCTFNVLVYADKDSEVPTDWVDSDPRILRDAEQVQLRSFSTSMHKIDCQVAYRVNP
What is the function of this protein?
Feedback control that prevents cells with incompletely assembled spindles from leaving mitosis.  It interacts with the anaphase promoting complex/cyclosome (APC/C) thereby inhibiting APC/C-dependent proteolysis, a step required for exit from mitosis.
What are the official names of this protein?
Mitotic spindle checkpoint component mad2.
What is the protein family that this protein belongs to?
Belongs to the MAD2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BIOA_ANOFW
Sequence: MEKGMVAMNEWIEKSKTYLWLPFTQMKDYEQHPLVIESGEGIFLTDVNGKTYYDGYSSLWLNVHGHRKKEIDDAIRAQLERIAHSTLLGAANIPAIALAEKLIEWTPSHLTRVFYSDSGAEAVEIALKIAFQYWRNIGENKKQKFVTLANGYHGDTVGAISVGAIDIFHTVYEPLMFTSYKAPFPLVYRHPSNDPNVVRDEALGALEALFAEHHEEIAAMIVEGMIQGAGGMHVMPKGYLKGVEQLCRQYNILFIVDEVATGFGRTGKRFAIEHEDVQPDIMTVAKGITGGYLPIAATLTTEAIYEAFYGDYTEFKTFFHGHSYTGNQLGCAAALANIQIFERERLIEQIQQKATFVAEQLASFNELNHVGDVRQLGLMCGIELVRDRRTHEPYPWTERMGYRTTLTMREKGMLTRPLGDVIVFMPPLASTFEQLEAMIAMMKEAIIETTEKRG
What is the function of this protein?
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA).  It is the only aminotransferase known to utilize SAM as an amino donor.
What are the official names of this protein?
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, 7,8-diamino-pelargonic acid aminotransferase, DAPA AT, DAPA aminotransferase, 7,8-diaminononanoate synthase, DANS, Diaminopelargonic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGD_PHOLL
Sequence: MKEHIAVDRNTYDQVMLPIYSPAQFIPVRGQGSRVWDQHGKEYIDFAGGIAVVALGHCHPTLVDVLKQQGEKLWHISNIFTNEPALILAQKLIDATFAERVFFANSGAEANEAAFKLARHYAIARHNPYKTKIIAFHQGFHGRTLFTVSVGGQPKYADGFGPKPADIIHVPFNDLDAVKAVIDDHTCAVVLEPVQGEGGVTAAAPAFIHGVRELCDKHQVLLVFDEVQSGMGRTGKLFSYMHYDVTPDIITTAKALGNGFPISAMLTTVNIASVMTPGAHGTTYGGNPLACAVANVAFDIINTPAVLAGVEKRHNLMVNFLNDINQKYSIFGEIRGKGLLIGAELKAPHQGKAKDILQLAAENGLMLLSAGGDVLRFTPSLIISEEEIAQGMERLEQVINQLV
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.
What are the official names of this protein?
Acetylornithine/succinyldiaminopimelate aminotransferase, ACOAT, DapATase, Succinyldiaminopimelate transferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_CAMJE
Sequence: MRANVLKRKLTLRIKRKKRIRAKISGCENFPRISVFKSNRTLYIQAIDDVKAVTLAAVDGRKLGVKANKEGAKKIAAEFAKTLKVKKIEQAVFDRNGYVYHGVIAALAESLRENGIRL
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PYRE_SALPC
Sequence: MKPYQRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDKDLPYCFNRKEAKDHGEGGSLVGSALQGRVMLVDDVITAGTAIRESMEIIQAHGATLAGVLISLDRQERGRGEISAIQEVERDYGCKVISIITLKDLIAYLEEKPDMAEHLAAVRAYREEFGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: NSP4_ROTW3
Sequence: MDKLTDLNYTLSVITLMNSTLHTILEDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVVKYCIVTIFNALLKLAGYKEQITTKDEIEKQTDRVVKEMRRQLEMIDKLTTREIEQVELLKRIHDKLMIRAVDEIDMTKEINQKNVKTLEEWENGKNPYEPKEVTAAM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: PG157_VAR67
Sequence: MEDLNEANFSHLLINLSNNKDIDAQYASTLSVVHELLSAINFKIFNINKKSKKNSKSIEQHPVVHHAASAGREFNRR
What is the function of this protein?
Required for the association between the dense viroplasm and the viral membranes to form the mature virion (MV).
What are the official names of this protein?
Protein OPG157, Protein A33.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG157 family.
Protein: DAPF_ESCF3
Sequence: MQFSKMHGLGNDFMVVDAVTQNVFFSPELIRRLADRHLGVGFDQLLVVEPPYDPELDFHYRIFNADGSEVAQCGNGARCFARFVRLKGLTNKRDIRVSTANGRMVLTVTDDDLVRVNMGEPNFEPSAVPFRANKAEKTYIMRAAEQTILCGVVSMGNPHCVIQVDDVDTAAVETLGPVLESHERFPERANIGFMQVVKREHIRLRVYERGAGETQACGSGACAAVAVGIQQGLLAEEVRVELPGGRLDIAWKGPGHPLYMTGPAVHVYDGFIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_RICFE
Sequence: MGKVIGIDLGTTNSCVAVMEGKEPKVIDNAEGERTTPSIIAFANSERLVGQPAKRQAVTNPRNTIYAVKRLIGRNFTDPMVRKDQGLVPYNIVKADNGDAWVEADNNKYSPSQISAFILQKMKETAENYLGEKVTQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGFEKSSSKTIAVYDLGGGTFDVSILEISDGVFEVKSTNGDTFLGGEDFDTRILNHLIDVFKKDSGIDLSKDPLALQRLKEAAEKAKKELSSTSATDINLPYITADSTGPKHLNIKFTRAELEKLVDDLIEKTIEPCRQALKDAGFKPTDIQEVVLVGGMTRMPKVQEAVKKFFGREPHKGVNPDEVVALGAAIQGGVLNKEVTDILLLDVTPLSLGIETLGGVFTRLIDRNTTIPSKKSQVFSTADDNQHAVTIRVFQGEREMAKDNKLLGQFNLEGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKASGKEQKVTIQASGGLSDSEIEQMVKDAEHNADEDKKRKELIETKNAADSLVYSTEKTLREYGDKLSSEEKGAVEEALASLKSALESEDASLIKEKTNNLTAANMKIGETMYKAQTENQHSEANTVNDEKVVDADFQDVDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: TMLH_NEUCR
Sequence: MRPQVVGAILRSRAVVSRQPLSRTHIFAAVTVAKSSSPAQNSRRTFSSSFRRLYEPKAEITAEGLELSPPQAVTGGKRTVLPNFWLRDNCRCTKCVNQDTLQRNFNTFAIPSDIHPTKVEATKENVTVQWSDNHTSTYPWPFLSFYLTSNARGHENDQISLWGSEAGSRPPTVSFPRVMASDQGVADLTAMIKEFGFCFVKDTPHDDPDVTRQLLERIAFIRVTHYGGFYDFTPDLAMADTAYTNLALPAHTDTTYFTDPAGLQAFHLLEHKAAPSRPPPPPPPPPPPSEEKEAAGSAAGEAAAAAEGGKSLLVDGFNAARILKEEDPRAYEILSSVRLPWHASGNEGITIAPDKLYPVLELNEDTGELHRVRWNNDDRGVVPFGEKYSPSEWYEAARKWDGILRRKSSELWVQLEPGKPLIFDNWRVLHGRSAFSGIRRICGGYINRDDFISRWRNTNYPRSEVLPRVTG
What is the function of this protein?
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
What are the official names of this protein?
Trimethyllysine dioxygenase, Carnitine biosynthesis protein 1, Epsilon-trimethyllysine 2-oxoglutarate dioxygenase, TML hydroxylase, TML-alpha-ketoglutarate dioxygenase, TML dioxygenase, TMLD.
What is the protein family that this protein belongs to?
Belongs to the gamma-BBH/TMLD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_STRM5
Sequence: MGGRKYFGTDGIRGRVGQGVISADFVLRLGNALGRVLVAQRGQDGRRPIVIIGKDTRISGYMFEAALEAGLVAAGADVQLLGPMPTPAVAFLTRTLGVDAGIVISASHNPHYDNGIKFFSAQGEKLDDATELALEAALDVPFTTAESEKLGKASRAREAVGRYIEFCKASVPRAFDLRGVRLVLDCAHGATYQIAPLLFRELGAEVIGIGAEPNGVNINAGVGSTHIDNLAAKVRETRADLGIAFDGDGDRVLMADDQGNPVDGDDLLYILARAWKDEGRLRGPVVGTLMSNYGVEKAFADLQIPFLRSNVGDRYVHQVLTEGGGVLGGEASGHLLCLDRATTGDGIVSALQVLVALRNNGQTLRQALKGLVRVPQKTVNVRLGNVSAKATVQAGSVQSALADAQHAVAGRGRAFLRPSGTEPVVRVTVEADDATLMQETLDRLSAAVREAAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: YJY5_YEAST
Sequence: MTSSLDDIEPTAYNNMEADEEYCRRNDIHDLSSVVGDAVSQGVPDMDGQTTDSSKDPEPNSEDKKAFPPSSGSFFSPNLQGQRKKVLLKFVFTNCLLAIICFTMFVLFWGALYDTSKYLHKVKLLVVIQEPPVVILDNNSSMVVPSISYALPTFINKIPCDWDIYNSPTFQAKFDVNTPQQVNDKVVDLVYDEKYWFAINIKPNATETLFESLINDTAPLFNSTLFNQVVYETGRDPTNLKSTILPVAQTIEEYYHTFYTLNYLPPLLTNITQVYRYALTNNARYIAAAGKYNYEYYDHRPFTDRILLAPTQIGVVYCLLLTFFQFLLYGPLHVEMAKVLRPANGLIYRIAMSWFTFFFASLFFCTTTAIFQVDFTKSFGRGGFVVYWMSTWLFMLAAGGANENAVMLVITLGPQYLGFWILSFVILNIAPSFFPLALNNNVYRYGYMMPVHNVIDIYRVIFFDVTRRKMGRNYGILVALIALNTALLPFVGKYASRKLKQKALVAAKQS
What are the official names of this protein?
Uncharacterized endoplasmic reticulum membrane protein YJR015W.
What is the protein family that this protein belongs to?
To yeast SNG1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CP19A_MOUSE
Sequence: MFLEMLNPMQYNVTIMVPETVTVSAMPLLLIMGLLLLIWNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMFHVMKHSHYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTIRPFFMKALTGPGLVRMVEVCVESIKQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNMLFLGIPLDESAIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIAVLVEKKRHKVSTAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVVGDRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQVKTLQKRCIENIPKKNDLSLHPNEDRHLVEIIFSPRNSDKYLQQ
What is the function of this protein?
A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively.  Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid.  Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid.  Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen.  Also displays 2-hydroxylase activity toward estrone.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Protein: HLDE_COXBU
Sequence: MADKIDISLYEKARIVVYGDIMLDRYWYGQASRISPEAPIPVVNVDQIEARPGGAANVALNVAALGASVELMGVVGDDQESRELETLLNKKSINCHFHRLNDHPTVTKLRVLGQNQQLLRLDFEKTLKHYEDKGLLQRYQHSLSHAQAVILSDYAKGALFNVTAPIQRAREKGLPVLVDPKSVDFSRYAGATLLTPNLKEFEAVVGHCRTDQELEFKARALIHQYRFEAILITRGKQGMMLIQKEGAAINLVAHAREVYDVTGAGDTVIAVMAASLAAGGDFYEAAQLANLAAGLVVRKLGAATVTVPELRRALHQITASHHGILSEKALLLAVADARAHGETIVMTNGCFDILHAGHVHYLEAAKAMGHRLIVAVNDDNSVRRLKGKDRPINSLQARMEVLTALRAIDWVVPFSEDTPARLITEVLPNILVKGGDYQPSQIAGGDEVVKNGGKVLTIPIKEGFSTSRLVEKMLN
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: TRY1_XENLA
Sequence: MKFLLLCVLLGAAAAFDDDKIIGGATCAKSSVPYIVSLNSGYHFCGGSLITNQWVVSAAHCYKASIQVRLGEHNIALSEGTEQFISSSKVIRHSGYNSYTLDNDIMLIKLSSPASLNAAVNTVPLPSGCSAAGTSCLISGWGNTLSNGSNYPDLLQCLNAPILTNAQCNSAYPGEITANMICVGYMEGGKDSCQGDSGGPVVCNGQLQGVVSWGYGCAMRNYPGVYTKVCNYNAWIQNTIAAN
What are the official names of this protein?
Trypsin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: DAPB_CLOPS
Sequence: MVKVILNGCSGKMGSVVSNLAETKFPNVEIVAGIDNNTMAQRSYPIFAKPEDCNVSYDVLLDFSRADALKSLVEFSKKTKKPLILCSTGYTAEDLKFIEESSKEIPLFRSANMSIGINLVNNLLKKVAPVLYENFDIELVERHHNQKVDAPSGTALLLAHTIQDSLNEETKLLYGREGIAKREKNEICVNTVRGGGIIGDHEVIFAGDGEVIEINHKAISRDVFAIGALKACEYMADKTKAGKYSMDDVLQLNF
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABV_CLOAB
Sequence: MIVKAKFVKGFIRDVHPYGCRREVLNQIDYCKKAIGFRGPKKVLIVGASSGFGLATRISVAFGGPEAHTIGVSYETGATDRRIGTAGWYNNIFFKEFAKKKGLVAKNFIEDAFSNETKDKVIKYIKDEFGKIDLFVYSLAAPRRKDYKTGNVYTSRIKTILGDFEGPTIDVERDEITLKKVSSASIEEIEETRKVMGGEDWQEWCEELLYEDCFSDKATTIAYSYIGSPRTYKIYREGTIGIAKKDLEDKAKLINEKLNRVIGGRAFVSVNKALVTKASAYIPTFPLYAAILYKVMKEKNIHENCIMQIERMFSEKIYSNEKIQFDDKGRLRMDDLELRKDVQDEVDRIWSNITPENFKELSDYKGYKKEFMNLNGFDLDGVDYSKDLDIELLRKLEP
What is the function of this protein?
Involved in the fatty acid synthesis (FAS II).  Catalyzes the reduction of the carbon-carbon double bond of crotonyl-CoA to yield butyryl-CoA.
What are the official names of this protein?
Trans-2-enoyl-CoA reductase [NADH], TER.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: CRCB_BORPA
Sequence: MLTFAPLNFLAIGVGATLGAWLRWVPGLRLNGAGWPWGTLTANLVGGYLIGVMVALIASHPEWPAWIRLAAVTGFLGGLTTFSTFSAETVDMLERGVYATAAAYAGASLAGSLAMTGLATVRLLLR
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DGOD_SALTY
Sequence: MKITHITTYRLPPRWMFLKIETDEGVVGWGEPVIEGRARTVEAAVHEFADYLIGKDPARINDLWQVMYRAGFYRGGPIMMSAIAGIDQALWDIKGKVLNAPVWQLMGGLVRDKIKAYSWVGGDRPADVIDGIEKLRGIGFDTFKLNGCEEMGVIDNSRAVDAAVNTVAQIREAFGSEIEFGLDFHGRVSAPMAKVLIKELEPYRPLFIEEPVLAEQAEYYPRLAAQTHIPIAAGERMFSRFEFKRVLDAGGLAILQPDLSHAGGITECYKIAGMAEAYDVALAPHCPLGPIALAACLHIDFVSRNAVFQEQSMGIHYNKGAELLDFVKNKEDFSMDGGFFKPLTKPGLGVDIDEARVIELSKSAPDWRNPLWRHADGSVAEW
What is the function of this protein?
Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
What are the official names of this protein?
D-galactonate dehydratase, GalD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: FABZ_BURO0
Sequence: MSTEKINLDIHKILTLLPHRYPILLVDRVLELEPHKGIKALKNVSINEPFFQGHFPKRPVMPGVLILEALAQAAALLTFAEEQPKDPENTLYYFVGIDGARFKRVVEPGDQLILNVTFERYIRGIWKFKAVAEVDGKVAAEAELMCTVKTADAAP
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
Protein: Y1411_THEKO
Sequence: MYPENYKRFLELIDKLREFEGALIVEGLRDEVALRNLGVRAEIIRLSRLPLSEVALIASSHKEVMILTDFDKKGEELAKKLLNYLAGYPCSVDIETWKELRKLVRKDIKGVEDLYGLYLRVVSVSDPLLEGIQ
What are the official names of this protein?
UPF0292 protein TK1411.
What is the protein family that this protein belongs to?
Belongs to the UPF0292 family.
Protein: LXN_RAT
Sequence: MEEIPPTHYAASRAASVAENCINYQQGTPNKVFKVQTVQQASKEDIPGRGHKYHLKFSVEEIIQKQVTVSCTAEVLYPRMGQGSAPEVNFTFEGEIGKNPDEEDNTFYQRLMSMKEPLQAQNIPDNFGNVSPQMKPVHHLAWVACGYVMWQNSTEDTWYKMAKIQTVKQVQRNDDFIELDYTVLLHDVASQEIIPWQMQVLWHPQYGTKVKHNSRLPKEAPAE
What is the function of this protein?
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4.  May play a role in inflammation (By similarity).
What are the official names of this protein?
Latexin, Endogenous carboxypeptidase inhibitor, ECI, Tissue carboxypeptidase inhibitor, TCI.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I47 (latexin) family.
What are the subcellular locations of this protein?
Cytoplasm.