PharMolix/UniProtQA huggingface dataset:
Protein: MPAB_PENRF
Sequence: MDKGTSFFTTPSFSATTRAIFNTMPQWFSFAVGLLIAYPLLINSLRYRRLKQLQKKFYFPTRESMAKMTDEEAFQIQKETAQLEFPFMFVKAGQFALFRTYGIPTISHLLIKTGQFSKPETSFKRYTDTAALIGEMVENSPTSQRAFLSVARTRFLHSGYQASGKILDTDLLYTLALFAVQPVNFIAAFEWRPLSDLERCAIGTFWKSLGDALGISSDILPSGKTGFRDGIHWLEEVDTWSQEYEVKYMVPDAQNRESADQATAVLLYNLPKVFHPVGLQFTSFMMDDRLRKAMLYVE
What is the function of this protein?
ER-bound oxygenase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (PubMed:26751579).  MpaB catalyzes the oxidative cleavage the C19-C20 double bond in farnesyl-DHMP (FDHMP) to yield FDHMP-3C via a mycophenolic aldehyde intermediate (By similarity).  The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC.  5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE.  MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB).  MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP.  The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP).  The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate.  The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C.  After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight.  Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps.  The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process.  Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (PubMed:26751579) (Probable).
What are the official names of this protein?
ER-bound oxygenase mpaB, Mycophenolic acid biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the mpaB oxygenase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MSRA_YERE8
Sequence: MQNFDKTAVIDAANALPGRLTPMPVATLHVVNGHSMTHVPEGMEVAIFAMGCFWGVERLFWQQPGVYSTAAGYSGGYTPNPTYHEVCSGRTAHAEVVRVVFDPAIISYKQLLQIFWENHDPAQGMRQGGDVGTQYRSAIYVLTPEQETQAQESQALFQQAMTKAGDSRAITSEIAAALPFYYAEDDHQQYLYKNPQGYCGLGGIGVCMPPNL
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: Y1460_ARCFU
Sequence: MPPPMIPPKLPPLEFIAAEALYSSIIFLICFLIYHRLREVYKLSDYRGFHFFSNTFLFLGLAYFLRFVVLLLSASGVMFEEISLEGLRGIMAFSMAFLAYSGSAAILYTIYSLLWRWLERFPGEVVINGVALVIALTSLLSRMPLVFLISQLALVFLLVAAIFVNYSHFRHESRSKRAYPLYILLFVFWLLNISLTFRFLPLEFRFAIYTLSVAVILIIAYRVLRKL
What are the official names of this protein?
Uncharacterized protein AF_1460.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LIS_CLABR
Sequence: MQLITNFSSSSSELQFLVDKVKRESLSSSSSNTQNLFLSTSPYDTAWLALIPHPHHHHHHGRPMFEKCLQWILHNQTPQGFWAAAGDNISDTDDDVTLDCLLSTLACLVALKRWQLAPDMIHKGLEFVNRNTERLVMKQKPSDVPRWFTIMFPAMLELAGASSLRVDFSENLNRILVELSQNRDDILTREEVDEKKQYSPLLLFLEALPAQSYDNDVLKQIIDKNLSNDGSLLQSPSATARAYMITGNTRCLSYLHSLTNSCSNGGVPSFYPVDDDLHDLVMVNQLTRSGLTEHLIPEIDHLLLKVQKNYKYKKASPKSLYSIAAELYRDSLAFWLLRVNNHWVSPSIFCWFLDDDEIRDHIETNYEEFAAVLLNVYRATDLMFSGEVQLVEARSFATKNLEKILATGNIHKTNADISSSLHKMIEHELRVPWTARMDHVENRIWIEEIASSALWFGKSSYLRLSCFHKMSLQQLAVKNYTLRQLVYRDELAEVERWSKERGLCDMGFCREKTGYCYYAFAASTCLPWSSDVRLVLTKAAVVITVADDFFDVEGSMVDLEKLTDAVRRWDAEGLGSHSKTIFEALDDLVNEVRLKCFQQNGQDIKNNLQQLWYETFHSWLMEAKWGKGLTSKPSVDVYLGNAMTSIAAHTMVLTASCLLGPGFPVHQLWSQRRHQDITSLLMVLTRLLNDIQSYLKEEDEGKINYVWMYMIENNQASIDDSVRHVQTIINVKKQEFIQRVLSDQHCNLPKSFKQLHFSCLKVFNMFFNSSNIFDTDTDLLLDIHEAFVSPPQVPKFKPHIKPPHQLPATLQPPHQPQQIMVNKKKVEMVYKSYHHPFKVFTLQKKQSSGHGTMNPRASILAGPNIKLCFS
What is the function of this protein?
Involved in the biosynthesis of the acyclic monoterpene S-linalool, a major component of the strong sweet scent of the C. breweri flowers.
What are the official names of this protein?
S-linalool synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: MURG_RHOP5
Sequence: MEPAPLILLAAGGTGGHLFPAEALGVVLMQRGLRVRLVTDSRALRYSGLFSREMTDVVPSETVRGRSPVALARTGAMLGAGTLKALTLMWRLKPAAVIGFGGYPTLPPLIAARLMKIPTLVHDSNAVMGRANRFLSAHVTAIATSLPGVLDRDPALAAKTTTTGTPMRPAILAAAAVPYAAPEPDGPLRLLVTGGSQGARIMADVVPHAIEQLSPELWRRLVLVQQVRDEDMARVRAVYDRLKLNFELEPFFSDLPARLASSHLVVSRSGAGTVAELAAIGRPSILVPLPGALDQDQFANAGVLAKADAAIRIAQHDFTPARLAQEITALAADPERLTAMAAGARGVGRLDAAERLADLVVEVAGIPAKTMMYQ
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SUCC_VIBA3
Sequence: MNLHEYQAKQLFAEFGLPVPEGFACDTAQEAFEAAGRISTAKKVVKCQVHAGGRGKAGGVELHDTKEGVKEFAQKWLGKNLVTYQTDANGQPVTKILVEEASNIANELYLGAVVDRATRKIVFMASTEGGVDIEKIAEETPELIHQSAIDPLVGPQAYQGRELAFKLGLVGDQIKQFVKIFMGLGQMFSQYDLALLEINPLVITGEGNLLCLDGKINIDSNAMYRQPKLREMHDPSQEDEREAHAAQWELNYVALDGNVGCMVNGAGLAMGTMDIVNLHGGKPANFLDVGGGATKERVAEAFKIILSDDNVKAVLVNIFGGIVRCDMIAEGIIGAVKEVGVTVPVVVRLEGTNADLGREVLANSDVDIIAAVSLTDAAQKVVAAAEAK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RL32_GEOSL
Sequence: MAVPKKKTSKSRKNMRRAHDFLTAPAASVCPQCKSPKLPHRACASCGTYKGREVVKTEEI
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: SECG_IGNH4
Sequence: MARKRRKGGEGLVTAIGLVRFYEEVEEKIKVPPEAVIGAAFALSIMTIALDLLLKAAR
What is the function of this protein?
Involved in protein export.  The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
What are the official names of this protein?
Preprotein translocase subunit SecG, Protein transport protein Sec61 subunit beta homolog.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RPPH_MARN8
Sequence: MIDSDGFRPNVGIILANHRGEVLWARRIGQDSWQFPQGGIKHNETPEDALYRELGEEIGLCASDVEIISCTRGWLRYRLPRRMVRHNSHPVCVGQKQKWFLLRMLSPDAHVRVDGTDSPEFDGWQWVSYWYPLGQVVSFKREVYRRALRELAPRLFHNMEQWHRAENPRRMKEHQK
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: LPL_THET8
Sequence: MRRAVILVLDRAGPV
What is the function of this protein?
Involved in control of the biosynthesis of leucine.
What are the official names of this protein?
leu operon leader peptide, leu operon attenuator peptide.
Protein: FRSA_ECOSM
Sequence: MTQANLSETLFKPRFKHPETSTLVRRFNHGAQPPVQSALDGKTIPHWYRMINRLMWIWRGIDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWATQAMVWQQKACAEEDPQLSGRHWLHAATLYNIAAYPHLKGDDLAEQAQALSNRAYEEAAQRLPGTMRQMEFTVPGGAPITGFLHMPKGDGPFPTVLMCGGLDAMQTDYYSLYERYFAPRGIAMLTIDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLESPRLKAVACLGPVVHTLLSDFKCQQQVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGYWKNDPFSPEEDSRLITSSSADGKLLEIPFNPVYRNFDKGLQEITDWIEKRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: MIAA_POLNA
Sequence: MSVSFAPAHSASPPNTSYIALAGPTASGKTAAALAIAEHVPVEIISVDSALVYRGMDIGTAKPSAEELAAVPHHLIDIRDPLHAYSAAEFVLDAQRLIAQISARGRLALLVGGTMLYFKALFDGLDEMPKADAAVRAVLAIEAAEKGWPALHAELAQVDPVTAARLAPNDSQRISRALEVFRVSGQPLSFFQQRNASKNIADNAGGTSAATLISLEPTDRAWLHGRIAQRFDAMLASGFVDEVRALRARGDLTPDLPAMRCVGYRQAWEALDGTSPMSELRDKGVFATRQLAKRQITWLRSMPQRRVVACDDPTALEQVLDLVKARTDAFQ
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: S5A2_HUMAN
Sequence: MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
What is the function of this protein?
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids.  It plays a central role in sexual differentiation and androgen physiology.
What are the official names of this protein?
3-oxo-5-alpha-steroid 4-dehydrogenase 2, 5 alpha-SR2, SR type 2, Steroid 5-alpha-reductase 2, S5AR 2, Type II 5-alpha reductase.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family.
What are the subcellular locations of this protein?
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: JAM1_RAT
Sequence: MGTEGKAGSKLLFLFTSMILGSLVQGKGSVYSPQTAVQVPENDSVKLPCIYSGFSSPRVEWKFVQGSTTALVCYNNQITVPYADRVTFSSSGITFSSVTRKDNGEYTCMVSEDGGQNYGEVSIHLTVLVPPSKPTVSIPSSVTIGNRAVLTCSEHDGSPPSEYSWFKDGVPMLTADAKKTRAFINSSYTIDPKSGDLVFDPVSAFDSGEYYCEAQNGYGTAMRSEAVRMEAVELNVGGIVAAVLVTLILLGLLIFGIWFAYSRGYFERTKKGTAPGKKVIYSQPSARSEGEFKQTSSFLV
What is the function of this protein?
Seems to play a role in epithelial tight junction formation.  Appears early in primordial forms of cell junctions and recruits PARD3.  The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly.  Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier.  Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration.
What are the official names of this protein?
Junctional adhesion molecule A, JAM-A, Junctional adhesion molecule 1, JAM-1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.
Protein: DSK_DROYA
Sequence: MGLRSCTHFATLVIPLWALAFCFLVVVPVPAQTNLQTSKGDRRLQDLESNMGAESDQPNANLVRPSLSRFGDKRNQKIITFGRRVPRPMIPIELDLLMDNDDENTKAKRFDDYGHMRFGKRGGDDQFDDYGHMRFGR
What is the function of this protein?
Drosulfakinin-0 (DSK 0) plays diverse biological roles including regulating gut muscle contraction in adults but not in larvae.
What are the official names of this protein?
Drosulfakinins.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYGB_HUMAN
Sequence: MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKVEPVYFKILSGVILEVVAEEFASDFPPETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP
What is the function of this protein?
May have a protective function during conditions of oxidative stress.  May be involved in intracellular oxygen storage or transfer.
What are the official names of this protein?
Cytoglobin, Histoglobin, HGb, Stellate cell activation-associated protein.
What is the protein family that this protein belongs to?
Belongs to the globin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CM3A_CONTE
Sequence: MLKMGVVLFIFLVLFPLATLQLDADQPVERYAENKQLLSPDERREIILHALGTRCCSWDVCDHPSCTCCG
What is the function of this protein?
Intracranial injection into mice causes scratching and hyperactivity (PubMed:15924437).  In vitro, inhibits proliferation of the mice ovarian cancer cells ID8 (PubMed:36235146).
What are the official names of this protein?
Conotoxin elongated-tx3a-a.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYK_CROS8
Sequence: MSEQQAQGAEAAVDLNNELKTRREKLAALREHGVAFPNDFRRDHTSDQLHADFDGKENEELEALNIEVCVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLPEGVYNEQFKKWDLGDILGARGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGLQDQEARYRQRYLDLIANDESRKTFKVRSQILAGIRQFMVGRGFMEVETPMMQVIPGGASARPFVTHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYKDLIELTESLFRTLAQDVLGTTQVPYGEETFDFGKPFEKLTMREAIKKYRPETDLADLDDFEKAKGIAQAVGIKVEKSWGLGRVVTEIFEEVAEAHLIQPTFITEYPAEVSPLARRNDENPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFQDQVAAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O51F2_HUMAN
Sequence: MTETSLSSQCFPMSVLNNTIAEPLIFLLMGIPGLKATQYWISIPFCLLYVVAVSGNSMILFVVLCERSLHKPMYYFLSMLSATDLSLSLCTLSTTLGVFWFEAREINLNACIAQMFFLHGFTFMESGVLLAMAFDRFVAICYPLRYTTILTNARIAKIGMSMLIRNVAVMLPVMLFVKRLSFCSSMVLSHSYCYHVDLIQLSCTDNRINSILGLFALLSTTGFDCPCILLSYILIIRSVLSIASSEERRKAFNTCTSHISAVSIFYLPLISLSLVHRYGHSAPPFVHIIMANVFLLIPPVLNPIIYSVKIKQIQKAIIKVLIQKHSKSNHQLFLIRDKAIYE
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 51F2, Olfactory receptor OR11-23.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPO10_HALMA
Sequence: MMVPVRCFTCGNVVGEHWEEFKARTREAEEPEDPEKVLDELGVERHCCRRMLVSHKDLVDIVSPYQ
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit N.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RELA_MYXXA
Sequence: MWGNVAPPLVQSYDCSSFDDSPERHPPTVSQYHPDPDLDIIKKAYVYSAKVHQGQLRKSGEPYLVHPLEVAGILGELKLDEASIVTGLLHDTIEDTLATEEELTELFGSEVAHLVDGVTKLSKFSASASLSQEEKQAENFRKMIIAMAQDIRVILVKLADRTHNMRTLDHMSEEKQARIAQETLDIYAPLANRLGISWIKTELEDLSFRYVKPQEFFALQAKLNKRKKEREKYIEDTCDLIRSKLAERGLKGEVSGRFKHVYSIYKKIKSQGIDFDQIHDIIAFRIIAPTAPSCYEALGLVHEMWKPVPGRFKDFIAIPKPNMYQSLHTTIIGPLSERVEVQIRTSEMHKIAEEGIAAHWKYKEGKAVISKDDEKFAWLRQLMEWQQDLKDPKEFLETVKVDLFTDEVFVFTPKGDVRSLPRGATPVDFAYAIHSDVGNRCVGAKVNGKIVPLRYKMKNGDTVEVLTSPQQHPSKDWLTFVKTSRAQQRIRGFIKQQQREKSLQLGRELADRELKRFQLNFNRLLKSGEMKKAAVDLGFRVEDDMLVAIGYGKVTPQQLSHRLVPQEKLNAAEAGGRADANPAATTSGGAGNSVLPGLSRVTDLAKRLVGRSNRSGVQIGGVDDVLVRFGRCCNPVPGDPIAGFITRGRGVTVHTVGCEKALATDPERRVDVSWDVRGDFKRPVTLRVLTADRPGLLADITNTFSKKGVNISQANCRATGDDRAVNTFEVIISDLKQLTDLMRTIERLQGVYSVERI
What is the function of this protein?
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.  This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity).
What are the official names of this protein?
GTP pyrophosphokinase, (p)ppGpp synthase, ATP:GTP 3'-pyrophosphotransferase, ppGpp synthase I.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
Protein: IF1_STAS1
Sequence: MAKQDVIELEGTVLDTLPNAMFKVELENGHEILAHVSGKIRMNYIRILPGDKVTVEMSPYDLTRGRITYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMRB_BACSU
Sequence: MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLMKELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGIVFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILGVIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKYGPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQLPREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAGVQHAFVFAMIVAIIGLIGAFFMKRVKVDH
What is the function of this protein?
Proton-dependent transporter.  May mediate the efflux of lincomycin.
What are the official names of this protein?
Lincomycin resistance protein LmrB.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EmrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DHE2_THUTH
Sequence: CAVVDVPFGGAKAGVK
What are the official names of this protein?
NAD-specific glutamate dehydrogenase, NAD-GDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: Y1680_STRPI
Sequence: MTKKQLHLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALLPKFLQLVEIKEDNPKLALVVDMRSRSFFSEIQAVLDELENQDGLDFKILFLDAADKELVARYKETRRSHPLAADGRILDGIKLERELLAPLKNMSQNVVDTTELTPRELRKTLAEQFSDQEQAQSFRIEVMSFGFKYGIPIDADLVFDVRFLPNPYYLPELRNQTGVDEPVYDYVMNHPESEDFYQHLLALIEPILPSYQKEGKSVLTIAMGCTGGQHRSVAFAKRLVQDLSKNWSVNEGHRDKDRRKETVNRS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein SPH_1680.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: FUCA_METM5
Sequence: MNLSNFIKICHLLYDRKYVVGSGGNVSIKNKNLIYITPTGSILGFLNEEDICVADIEGNILKGKPTSELNMHLKIYQNKESINAIVHTHSMYCTAFSALDKKLELLTPEAEIFIKKIAYVDYFPCGSLELAENVSACVEDSIILKNHGIVTLGKDITEAYVKTEVLEEIAQLNYIMNNLGE
What is the function of this protein?
Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde.  Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde.
What are the official names of this protein?
L-fuculose phosphate aldolase, L-fuculose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. AraD/FucA subfamily.
Protein: FIXJ_AZOC5
Sequence: MPESLPVHVIDDDDAVRESLAFLLESSGLAVTQHTSAAAFLDAGVPLDRGCIVTDVRMPGISGLELLKELNARGAHMAVIVMTGHGDVPLAVEAMKLGAADFLEKPFDDAAIIAAVRASLGRSAEQGRQEDARSEVGKRIAGLSQRERQVLECLVNGLANKTIAYDLGISPRTVEVYRANVMTKMKAASLPELVRMALLAGVAPADDATPT
What is the function of this protein?
FixJ, when activated by FixL, induces the expression of both nifA, required for activation of classical nif and fix genes, and fixK, required for fixN activation.
What are the official names of this protein?
Transcriptional regulatory protein FixJ.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_ANADE
Sequence: MSSDAAAQERLPGLLLVLSAPSGAGKTTLAHRLREASPDAVFSISATTRAPRGAEREGVDYHFVTAERFTELVAQGAFAEWAEVHGQRYGTLRATVDEALAAGKLALFDIDVQGGAQIKAAWPQQAATVLVLPPDEAELERRLRGRDTDSDETIRRRLVAARAEVARGLGSYDYVVVNDVLEGALAQLQAIVRHERLRHAGRWDPEAARVAEACRRSAAPLGGWAS
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_CLOP1
Sequence: MNNLILVKYASEIFLKGLNKNKFERKLKENIRKKLKDIDHEFITDQNRWFIKSEDLDGVIERVKKVFGVKELCLVTQVEGDFDSIKEEGLKKIKESKAKSFKVETNRANKKFPMNSMEVSRAVGGYILSELGDEIEVDIHNPECKLYVEIRGNAYVFTDKDKIKAVGGLPYGMNGSTMVMLSGGIDSPVAAYLMARRGVETHCVYYHSHPYTSERAKDKVKELAKIVGRYTEKITLYVVPFTEIQMDIIEKCREDELTIIMRRFMMRVACELSERKKIQSITTGESIGQVASQTMEGLMVSNDVSDRPVFRPLIAMDKEDIMDIARDIDTYETSILPYEDCCTIFVPKHPKTKPRVKDMIIAERKLDIEALVNKAIDEMETFIFE
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.