PharMolix/UniProtQA huggingface dataset:
Protein: SARCO_MOUSE
Sequence: MERSTQELFINFTVVLITVLLMWLLVRSYQY
What is the function of this protein?
Reversibly inhibits the activity of ATP2A1 and ATP2A2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+).  Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle (PubMed:21697544, PubMed:26816378).  Required for muscle-based, non-shivering thermogenesis (PubMed:22961106).
What are the official names of this protein?
Sarcolipin.
What is the protein family that this protein belongs to?
Belongs to the sarcolipin family.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: AMP2_PAEAL
Sequence: FCKSLPLPLSVK
What is the function of this protein?
Has bactericidal activity against Gram-positive bacteria L. plantarum ATCC 8014 and B. cereus ATCC 14579 as well as against Gram-negative bacteria E. coli ATCC 25922 and S. enteritidis ATCC 13076.
What are the official names of this protein?
Antimicrobial protein AN5-2.
Protein: GLYA1_MYCTO
Sequence: MTAAPDARTTAVMSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFAPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLHALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEFRPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAATPEFADRQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAEDLLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIATALATGSSVDVSALKDRATRLARAFPLYDGLEEWSLVGR
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 1, SHM1, SHMT 1, Serine methylase 1.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TREM1_HUMAN
Sequence: MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP
What is the function of this protein?
Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its lignad.
What are the official names of this protein?
Triggering receptor expressed on myeloid cells 1, TREM-1, Triggering receptor expressed on monocytes 1.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=Recruited to lipid rafts when activated. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: API_OSTOS
Sequence: MKLVVLCVLCGIALAAPRQKRLTVGTIAVTGGVGGSTGCVVTGNVLYANGFRLRELNPSEQQELVNYEKQVADYKAAVKQALKERQESLKSRMAGKKEKAVTPKEEDLPKAPQKPSFCTEDDTTQFYFDGCMVQGNKVYVGNTFARDLDQNEIQELKEFEKKQTVYQEYVQKQIQAQVSNLFGGADFFSSFFNGGSEKGSSTTTVAPVLPEDAPEQPAGPNFCTRIY
What is the function of this protein?
Aspartyl protease inhibitor.
What are the official names of this protein?
Aspartyl protease inhibitor.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I33 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RP5L1_ARATH
Sequence: MSDMDDEITRIFKVRRTVLQMLRDRGYTIEESDLNLKREEFVQRFCKTMNKVNKEALFVSANKGPNPADKIYVFYPEGPKVGVPVIKKEVAIKMRDDKVHRGIVVVPMAITAPARMAVSELNKMLTIEVFEEAELVTNITEHKLVNKYYVLDDQAKKKLLNTYTVQDTQLPRILVTDPLARYYGLKRGQVVKIRRSDATSLDYYTYRFAV
What are the official names of this protein?
DNA-directed RNA polymerase subunit 5-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YPFN_ECOBW
Sequence: MDWLAKYWWILVIVFLVGVLLNVIKDLKRVDHKKFLANKPELPPHRDFNDKWDDDDDWPKKDQPKK
What are the official names of this protein?
UPF0370 protein YpfN.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: DRE2_COCP7
Sequence: MERMLLLSPPSLAARPERLNTILSSHSRYATDLQMLDRVAAGLVSLPQSTYDIVMLLTDVDGLGTGSTSAMGRGVIQSVVRALRPGGKFKRENGTFPSTECPDNTELMLAGLVFDDTGGLLKPDFGPENIVPLKLGKRKPVHSVSSNGTGTSGPHVNMQLSTGSMLKGQTTTIKGVGFVDFTDDPSLSEADIYSGQTDDELIDEETLLDGEDMGRPIIQPPECRPKAGKRRRACKDCTCGLAERLREEDKAARAKADATLETMKLAPKELAEVDFTVQGKLGSCGNCALGDAFRCDGCPYIGLPPFKPGEEVRLLSNDVQL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein DRE2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: CYSD_CHLPM
Sequence: MPSYRLSHLKQLEAESIHIIREVAVEFENPVMLYSIGKDSSVMVRLAEKAFYPGKVPFPLLHVDSKWKFREMIEFRDSYARENNWGLIVHSNEEAFADGVGPFSHGSQVHTDLMKTQALLQALGKYKFDAAFGGARRDEEKSRAKERIFSFRDRFNQWDPKNQRPELWEIYNTKVHKGESIRVFPISNWTELDIWEYIRLEKIPIVPLYYAKERPVVRVEGNLIMVDDDRMPQEMRARAEMRVVRFRTLGCYPLTGAVESSASTIEEIVAEMMTTTKSERTTRVIDFDQEASMEQKKREGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: DNAJ_ECO8A
Sequence: MAKQDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDSQKRAAYDQYGHAAFEQGGMGGGGFGGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMELTLEEAVRGVTKEIRIPTLEECDVCHGSGAKPGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCNKCHGHGRVERSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNEKQKQLLQELQESFGGPTGEHNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOI_RHOCA
Sequence: MAFDYVRAAKYFVLWDFIKGFALGMKYFVAPKPTLNYPHEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIDAEPRDDGSRRTTRYDIDMTKCIYCGYCQEACPVDAIVEGPNFEYATETREELFYTKEKLLENGARWEAEIARNIEMDAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HLDE_HELPG
Sequence: MKKILVVGDLIADYYLWGKSERLSPEAPVPVLEVKKESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGKHFISALKARNIDTSGILTDKTRCTTLKTRIIAQNQQIARVDKEIKDPLNADLRKNLLDFITEKIQEIDGVILSDYNKGVLDFELTQTIITLANKHHKLILCDPKGKDYSKYSHASLITPNRFELEHALHLKLDSHASLSKALQILKETYQIAMPLVTLSEQGIAFLEQGELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILPLEKLLETLEHNQQKIVFTNGCFDLLHKGHASYLQKAKALGDILIVGLNSDASVKRLKGDKRPIVSEKDRAFLLASLSCVDYVVVFEEDTPIQLIQALKPDILVKGADYLNKEVIGSEFAKETRLMEFGEGYSTSAIIEKIKRTCND
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: DRS1_NEUCR
Sequence: MAPSQKRKAIDDDFILTISDNEEDIPLEEEQEVVPRKKAKTATQQSNKQKKKNNKKSKKQQQTEDDDDEAETKEDDAADLGIWGDNDEDDGAMDTEFQFVVDGQNEVDAEFDGWGFEGAHKGVVKGANAGGDKKAVDIDEIIRRRRERKAAKEGKTTATKEEEDKMEVDEEEDDIEEIDVDLDDDEDGVLADDAFGMGVGSDVEEEEEKQDAKMGGVDGEDEDSEGEDGEKKGEDEDEGDASDDDSVATAVEHPDDVQSSDDEEGIDEEEEAKMKEFFAPEEENQPKKKGEMSSFQEMSLSRPILRGLTSVGFTKPTPIQAKTIPISLMGKDVVGGAVTGSGKTAAFVVPILERLLYRPKKVPTTRVVILTPTRELAIQCHAVAVKLASHTDIKFCLAVGGLSLKVQEAELRLRPDVVIATPGRFIDHMRNSASFAVDTIEILVLDEADRMLEDGFADELNEILTTLPKSRQTMLFSATMTSSVDRLIRAGLNKPVRIMADSQKKTAGTLVQEFVRLRPGRESKREGYLLHICKTIYTERVIIFFRQKKIAHKMRIIFGLFGLSCAELHGSMNQAQRIQSVEDFRDGKVNFLLATDLASRGLDIKGVDTVINYEAPQTPEIYVHRVGRTARAGRSGTAITLAAEPDRKVVKAAVKAGKSQGAKISSRIIDPADADKWQAEIDELEDEIEEIMQEEKEEKQLQNMEMQVKKGENMIKYEDEISSRPKRTWFETQEDKKKAKAAGRAELNGVRDKLKSKNEGKLSNKDRKKLDTMQERKQERTYKKGSAERAGKGAVLNLKKVVKKVGRSAGPKKKGGNAGKGGKGKGRRK
What is the function of this protein?
ATP-binding RNA helicase involved in ribosome assembly.
What are the official names of this protein?
ATP-dependent RNA helicase drs1, DEAD box RNA helicase 11.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SCX4_TITPA
Sequence: MNYFVLIAVACLLTAGTESKKDGYPLEYDNCAYDCLGYDNKKCDKLCKDKKADSGYCYWAHILCYCYGLPDNEPIKTSGRCRPGKK
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Toxin Tpa4, T-alpha* NaTx3.7.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS4_PSEE4
Sequence: MLIIPAIDLKDGACVRLRQGRMEDSTVFSDDPVSMAAKWVEGGCRRLHLVDLNGAFEGQPVNGEVVTAIAKRYPNLPIQIGGGIRSLETIEHYVKAGVSHVIIGTKAVKQPEFVAEACKAFPGRVIVGLDAKDGFVATDGWAEVSAVQVIDLAKRFEADGVSAIVYTDIAKDGMMQGCNVPFTKALAEATSIPVIASGGIHNLGDIKALLDAKAPGIIGAITGRAIYEGTLDVAEAQAFCDNYQG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP83_LEIDO
Sequence: TKKVKEVTKEYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPMATKHFSVEGQLEFRSIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLEMFDEVAENKEDYKQFYEQFGKNIKLGIHEDTANPKKLMEFLRFYSTESGLEMTTLKDYVTRMKEGQKSIYYITGDSKKKLESSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKRCKTMKEVLGDKVEKVTVSDRLSTSPCILVTSEFGWSAHMEQIMRNQAVRDSSMSAYMMSKKTMELNPRHPIIKVLRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLEDPTGYAKRINRMIKLGLSLDEEEEAAEATVVETAPAEVTVGTSSMEQVD
What is the function of this protein?
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.  Undergoes a functional cycle that is linked to its ATPase activity.  This cycle probably induces conformational changes in the client proteins, thereby causing their activation.  Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
What are the official names of this protein?
Heat shock protein 83, HSP 83, HSP 90.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUCA_PSEAE
Sequence: MSREALQETLSAVMDNEADELELRRVLAACGEDAELRSTWSRYQLARSVMHREPTLPKLDIAAAVSAALADEAAPPKAEKGPWRMVGRLAVAASVTLAVLAGVRLYNQNDALPQMAQQGTTPQIALPQVKGPAVLAGYSEEQGAPQVITNSSSSDTRWHEQRLPIYLRQHVQQSAVSGTESALPYARAASLENR
What is the function of this protein?
Negative regulator of the sigma factor AlgU.  Plays a role in the differentiation of P. aeruginosa into the alginate-producing form.  Inactivation of mucA causes a switch from the non-mucoid to mucoid state resulting in constitutive expression of alginate biosynthetic genes.
What are the official names of this protein?
Sigma factor AlgU negative regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the RseA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: YDIB_ECOHS
Sequence: MDVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPFTYMAFEVDNDSFPGAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIKGKTMVLLGAGGASTAIGAQGAIEGLKEIKLFNRRDEFFDKALAFAQRVNENTDCVVTVTDLADQQAFAEALASADILTNGTKVGMKPLENESLVNDISLLHPGLLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFTLWTGKDFPLEYVKQVMGFGA
What is the function of this protein?
The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate.  Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively.  It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.
What are the official names of this protein?
Quinate/shikimate dehydrogenase, NAD-dependent shikimate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: MOS_VULGR
Sequence: QLCLLQPLGSGGFGSVYKATYHGATVAVKQVKKSSKNRLASRQSFWAELNVARLQHNNVVRVVAASTCAPASQNSLGTIIMEYVGNITLHHVIYGTGDAWRQGEDDEGGCGRKALSMEETVCYSCDIMTGLAFLHSQDIVHLDLKPANIFITEQGVCKIGDFGCSQKLEEGLSQSPHVCQQGGTYTHRAPELLKGERVTA
What are the official names of this protein?
Serine/threonine-protein kinase mos, Oocyte maturation factor mos.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: EX7S_YERPB
Sequence: MPKKAASPEIKAASFETSLSELEQIVTRLESGELPLEDALNEFERGVQLARQGQQTLLQAEQRVQILLSDDVDAPLKPFTPDTE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_SHEPW
Sequence: MATVNQLVRKPRAPKVDKTNVPALNACPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCAGVSERRQGRSKYGAKRPKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: FTHS_CLOB8
Sequence: MKSDIQIAQEAKMEPIKNVAEKLGLCEDDIEYYGKYKCKISLDVYDKVKNNNNGKLVLVTAINPTPAGEGKSTVTVGLGQALNRIGKKAVIALREPSLGPVFGIKGGAAGGGYAQVVPMEDINLHFTGDMHAITSANNLLSAAIDNHIHQGNVLRIDSRRIVFKRVMDMNDRALRHIIVGMGGKVNGFVREDGFNITVASEIMAILCLASDLEDLKERMGNIVIAYNLDGNPVYAKELEIQGAMALLMKDAIKPNLVQTLENTPALIHGGPFANIAHGCNSIMATKLALKLGDVVITEAGFGADLGAEKFFDIKCRYGNLEPECVVVVATIRALKHHGGVAKTELNIPNVEALKDGIANLEKQIENIKKFKITPVVAINKFVTDSSEEVEFIKDFCDRIGVKVALCDVWAKGGEGGIDLANIVLDALENSESNFEPIYDKEKSIREKIFTIASEIYGADKVNYTPAAKKQIDELEKFKLDKLPICMAKTQYSLSDNPSLLARPTGFDITVKEVRVSNGAGFIVVQTGDIMTMPGLPKVPAANKMDVLKSGEIIGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: TATA_SHEFN
Sequence: MGGISIWQLLIVALIVILLFGTKKLRSLGGDLGGAVKGFKNAMTPEDENKSLDDKEKDQTAATSQQAAEKQPETESKDKQA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DAPF_PARPJ
Sequence: MKLKFTKMHGAGNDFVVLDGYTQPVNLTPAQVRALADRHFGVGADQLLLVEKPTVAGVDFRYRIFNCDGGEVEHCGNGARCFVKFVRDSGLTDQRSVRVQVQKGTITLTMQENGEVLVDMGTPVFDPERVPFATKGLQGRGEGADTLWPLDVNGTTRWISVVSMGNPHAVQVVDDVEAFPVLVEGPVIERHARFPQRVNAGFMQIVGRSEIKLRVYERGAGETLACGTGACAAVAAGIRRGLLDAPVLVHTHGGKLTITWDAAQADQPLLMAGPAATVFEGEIELPDSLADSLANSQAA
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_SALRD
Sequence: MSEVLDDKPEVLVQKLDALPTDPGVYKFLDDEESVLYVGKAKNLRNRVRTYFQQSRQRDGRIEVMVQKAVDVDIIVTDTEAEALILENNQIKELQPRYNVNLRDDKTYPYICIKNERFPRVFKTRTVKQDGSEYFGPYADVSKMNSMMDAIRSVFQLRTCSLDLTEEKIEAGKYDVCLQHHIDNCKAPCVGKQSEADYMETIEQVKKLLNGQTQELMDLLKDEMQRQSDAHNFEEAARLRDQVKALKDYSQQQKVVSQDFADRDVFALHVERDEDIGCGVLFQVREGKMIGKRHKFLRSVEERSDAELILSLVENYYAEANFYPEEVLLSHDPNDHPAQDTHALEELLRQEQGHQVPIKVPQRGEKASLVRMATSNAKLQVGEWKTQQMKRERNRIPESIKALGEALNMEAPPRRVDGIDVSHHGGKETVASCVVFTDATPRKSDYRTYKIRSTEEGTPDDYKAMREVVRRRYRRMVEEDGPWPDLVVIDGGKGQLSSAVEMLKEVGAFDRFPVIGLAKRLEEVYRPGDSDPVFLAKDSPALQLLQKVRDEAHRFAVTYQRKRRKKKTLQSELLDIHGIGPKTAKKLLGEFGSAAKVKEADEEALAEVVGPAKAETITDYYDETEAPAPAETE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPHB_SACS2
Sequence: MSILSLVGLGISKKFITDSAIETLSNSDIIIFDRYTSRSCDINVDVLRRLVKGEREFIEADRSLLENNSKAIIDYLDKGYNVSIASIGDALIATTHVSLLIEAKHRGHEVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKNEKAMTANEALQILLRLEERHKKSVLSKSDIIIVGARLGCDDERIIALKVEEATSFDFGNTPHIIIIPGNLHYMEADAIKWILRS
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: NEP_I34A1
Sequence: MDPNTVSSFQDILLRMSKMQLESSSGDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNEKWREQLGQKFEEIRWLIEEVRHKLKITENSFEQITFMQALHLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.