PharMolix/UniProtQA huggingface dataset:
Protein: TAF5_HUMAN
Sequence: MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGDGGTPKPTVAVSAAAPAGAAPVPAAAPDAGAPHDRQTLLAVLQFLRQSKLREAEEALRREAGLLEEAVAGSGAPGEVDSAGAEVTSALLSRVTASAPGPAAPDPPGTGASGATVVSGSASGPAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECSLDCHRAELSQLFYPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDFRTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLAGEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAYSPQ
What is the function of this protein?
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).  TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).  The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:8758937, PubMed:8942982, PubMed:9045704).  The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473).  TAF5 is involved in two modules of TFIID, in TFIID-A together with TAF3 and TBP, and in TFIID-B with TAF8 (PubMed:33795473).  Involved in contacts between TFIID and TFIIF in the PIC (PubMed:33795473).
What are the official names of this protein?
Transcription initiation factor TFIID subunit 5, Transcription initiation factor TFIID 100 kDa subunit, TAF(II)100, TAFII-100, TAFII100.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TAF5 family.
Protein: UP11_PSEMZ
Sequence: RATVAQPR
What are the official names of this protein?
Unknown protein 11.
Protein: ATP6_LISW6
Sequence: MGEEFPTISLLGIDFNLSNILMITVTCVIVLLIAIICTRNLQRRPTGKQNFIEWIMDFVRGIINSNMDWKTGGRFHVLGITLLMFIFVANMLGLPFQIAINDEVWWRSPTADPIVTLTLAIMVLGLTHYYGIKMRGFKHYFVGTYFSPMKFLFPLKLVEEFANTLTLGLRLYGNIFAGEVLLTIIATQLAHMNIFVGVLAIIPALLWQGFSIFIGAIQAYIFTMLTMVYMSHKVSDEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LRP10_MOUSE
Sequence: MLSALPLLFLLLGGALARPDRITFPRSACEAPPAVLSEVQGTLQRPLGRDSRSSPANCTWVILGSKDQTVTVRFQKLHLACGSEHLILHSPLQPPISLCEAPSGPLQLPGGNVTITYSYAGARAPMGQGFLLTYSQDWLLCLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGCSSDPFPNLNPAPAPTLACNLTLEDFYGVFSSPGYSHLASVSHPQSCLWLLDPHDGRRLAVRFTALDLSYGDAVHVYDGAGPPETPRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSSGRGFNATYHVRGYCLPWDRPCGLGSGLGASENLGERCYSEAQRCDGSWDCADGTDEEGCPGCPPGHFPCGAAGTPGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDCSYALPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGTSGGRRRQRGRSIRRLVRRLRRWGLLPRTNTPARAPETRSQVTPSVPSEALDDSTGQACEGGAVGGQDGEQAPPLPIKTPIPTPSTLPALATVSEPPGPLPSVPVESSLLSGVVQVLRGRLLPSLWSPGPTWTQTGTHTTVLSPEDEDDVLLLPLAEPEVWVVEAEDEPLLA
What is the function of this protein?
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction.  May be involved in the uptake of lipoprotein APOE in liver.
What are the official names of this protein?
Low-density lipoprotein receptor-related protein 10, LRP-10.
What is the protein family that this protein belongs to?
Belongs to the LDLR family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Membrane, coated pit.
Protein: FHR3_HUMAN
Sequence: MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGYNANTSILSFQAVCREGIVEYPRCE
What is the function of this protein?
Might be involved in complement regulation.
What are the official names of this protein?
Complement factor H-related protein 3, FHR-3, DOWN16, H factor-like protein 3.
What are the subcellular locations of this protein?
Secreted.
Protein: SUCC_ALKMQ
Sequence: MNIHEYQGKEIMKQYGISVPRSRITFTVEEAVQAAIDLGCEVIAVKAQIHAGGRGKAGGVKITRSLEETKSAAEAILDKILITKQTGPEGKVVNQVLIEEGLKIEKECYLSCAVDSTTSTVVLIGSPEGGMDIEEVAEKTPHKIFKESIDPAIGLQQYQARRLAFNMGINEACLQEAAQCIMNIYRLFMEKDCSMVEINPLITTEEHKVVALDCKVCFDDNSLCRHPEILKYRDLTEEDPREVQASKYDLSYISLSGNIGCMVNGAGLAMATMDMIDHFGGAPANFLDVGGGATAEKVKEAFKILISDKKVAGIFVNIFGGIMKCDVIATGILQAVNALDLDVPLVVRLEGTNVELGKEILKSSWLDVITVNSMAEGAEKIVALVNGKGVVRDERLN
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: FOLD_ACHLI
Sequence: MLLDGRKTADILNEALRVKVQYLTKKPKLEIILIGNDEASKSYVKGKLNTASNLGMEVHINYLDEAIDQLSVEALIQKLNTDKGVHGILLQLPIPKHLDSDYLISLIDYKKDVDGFHTMNQGLLFQKKDGIRPATPLGIMMLLDFYNIPIEGKHVVIIGRSQIVGAPLSKMFLDRNATVTITHSKTKNLPSITKQADILVAAIGKPKFVTKDMVKVGAVVVDVGINRVDKKLVGDVDFEHVEPIASYITPVPKGVGPMTICALAHNLYALYLKQEKE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CYB_PYTSE
Sequence: MPHHYILTLFGLLPVATNISTWWNFGSMLLTCLALQTLTGFFLAVHYTANINLAFSSIIHIIRDVPHGWMMQNLHAIGASMFFICIYIHIARGLYYGSYLNKETWMSGITLLIILMATAFFGYVLPWGQMSFWAATVITNLLTAVPYLGTTLTTWLWGGFAINDPTLTRFFALHFILPFAIISLSSLHVILLHEEGSSNPLGTNPDIDKIPFHPYHSYKDLLLLTLMILSLLIIVSFFPDIFNDPDNFSKANPLVTPQHIKPEWYFLFAYGILRSIPNKLGGALALVMSIMILLTIPFTHTSTMRSMTFRPLSQLMFWTLVSTFITITWAATKPVEPPFIIISQVTATLYFTFFISTPILGWLENKMTNHP
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NDK_HELPY
Sequence: MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVVAMKRLHLSVKDAENFYAIHRERPFFKDLIEFMVSGPVVVMVLEGKDAVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDSLENAHNEIAFFFAARDL
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KEFB_KLEP3
Sequence: MAGSDLLLAGVLFLFAAVIAVPLASRLGIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFIIGLELNPAKLWRLRSSIFGVGAAQVMLSAAILGGLLMTTGFSWQAAVVGGIGLAMSSTAMALQLMREKGMSRSESGQLGFSVLLFQDLAVIPALALVPLLAGSADEHVNWLTVGMKVLAFAGMLIGGRYLLRPVFRFIASSGVREVFTAATLLLVLGSALFMEALGLSMALGTFIAGVLLAESEYRHELEIAIDPFKGLLLGLFFISVGMALNLGVLYTHLLWVAVSVAVLVAVKMLVLYLLARLYGLRSSERMQFAGVLSQGGEFAFVLFSLPASQRLFQHDQMALLLVAVTLSMMTTPLLMKGIDKLLSRRLNPADDTDEAPWVEDDKPQVIIVGFGRFGQVIGRLLMANKMRITVLERDISAVNLMRNYGYKVYFGDATQLELLRSAGAEEAQSIVITCNEPEDTMRLVEMCQQHFPHLHILARARGRVEAHELLQAGVTQFSRETFSSALELGRKALITLGMHPHQAQRAQLHFRRLDMRMLRELMPVHTDTVQVSRVREARRELEEIFQREMQKESRQLDGWDEFE
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefB, K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1387_PELTS
Sequence: MRQKFRFAAYVLAGFGLIFLALTIAGARLYTDWLWFQSVNYQRVFATIIISDLGLRLAVGLTFFVLLFLNLMLTRRPLLKVSQNSAIIREKDVLTIQSSPLSQLITPKLLLLAFIALSALMAFLFNFTVAGDWITFQKFLHPTSFGIKDPVFNLDIGFYVFKLPFYIFIYKVINWVILVSAFWVLAAYFVVYFIQGNPGAIFRNISARYHFSFLAAIFFGLKAAGYQLEQYSLLFSHHGAVWGPGYTATHATLLAYKVLTYIALLCALAILINLFLRRFKLVIYSIGVLLIASVLLGGIYPAAVQKFMVTPNEIAMERPYLERNINFTRLAYNLDEIEKRYFPAGRVLTAEDIRANQDTISNIRLWDWEPLQQTYGQLQEMRLYYEFKDIDVDRYIVNGRYRQVMVAARELNQEHLPAQAKTWVNQRLKFTHGYGIAMSPVNELTGEGLPAFFLKDIPPTGPTDLQVTRPEIYYGEASDQYVIVNTRSQEFDYPKGEENVFSTYEGDGGVRVANFLRRLMFAFSLGDYKLLLSSEVDNNSRVLYYRNIRQRVPKIAPFLQYDNDPYIILSEGKLYWMWDAYTTTDKFPYSEPYNKNDNYIRNAVKVVVDAYTGKVDFYISDSSDPLVLTYSKIFPGMFKPLDSMPEDLRRHIRYPVDLFKTQAKMYAVYHMEDPQVFYNKEDKWNLPTEIYASEEKPMEPYYTVIKLPGENKPEYVLILPFTPQNKKNMIAWLAARSDGENYGKLISYSFPKQELVYGPMQVEARINQDTTISQQLTLWDQGGSRVIRGNLFAVPIKDALLYVEPLYLQAEQSRMPELRRVIVAHGEKVVMEPTLDKALEKIFGEGATVQKSVQQPVDVTQPQPEKSIAELANTANQIYDEAMKKIKAGDWAGYGEDLSRLKQVLAELAERAGK
What are the official names of this protein?
UPF0182 protein PTH_1387.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TIM22_HUMAN
Sequence: MAAAAPNAGGSAPETAGSAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIEKAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLIESYRGTSDWKNSVISGCITGGAIGFRAGLKAGAIGCGGFAAFSAAIDYYLR
What is the function of this protein?
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel.  Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim22, Testis-expressed protein 4.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CH60_ENTAG
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVASAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLEDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLVIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVGQIRKQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVDDALHATRAAVEEGVVAGGGVALVRVAAKLAGLTAQNEDQNVGIKVALRAMEAPLRQIVSNAGEEPSVVANNVKAGEGNYGYNAATEEYGNMIDFGILDPTKVTRSALQYAASVAGLMITTECMVTDMPKGDAPDLXAAGMGG
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_ALKMQ
Sequence: MIQQESRLKVADNSGAKELLCIRVLGGTRRRYANVGDVIVCSVKSATPGGVVKKGEVVKAVVVRTVSTTRRKDGTYIKFDENAAVIIKDDKQMVGTRIFGPVTRELRDRDFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ARBB_DICCH
Sequence: MSNPFPAHFLWGGAIAANQVEGAYLTDGKGLSTSDLQPQGIFGEIVTRQPGDSGIKDVAIDFYHRYPQDIALFAEMGFTCLRISIAWTRIFPQGDEAEPNEAGLAFYDRLFDELAKYGIQPLVTLSHYEMPYGLVEKHGGWGNRLTIDCFERYARTVFARYRHKVKRWLTFNEINMSLHAPFTGVGLPPDSDKAAIYQAIHHQLVASARAVKACHDMIPDAQIGNMLLGAMLYPLTSKPEDVMESLHQNREWLFFGDVQVRGAYPGYMHRYFREQGITLNITAQDKQDLKATVDFISFSYYMTGCVTTDEAQLEKTRGNILNMVPNPYLESSEWGWQIDPLGLRYLLNFLYDRYQKPLFIVENGLGAKDKIEENGDIYDDYRIRYLNDHLVQVGEAIDDGVEVLGYTCWGPIDLVSASKAEMSKRYGFIYVDRDDAGHGSLERRRKKSFYWYQSVIASHGKTLTR
What are the official names of this protein?
6-phospho-beta-glucosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: KATG_NEOFI
Sequence: MTQDKCPFKEQPSQPNFAGGGTSNKDWWPDRLKLNILRQHTAVSNPLDADFDYAAAFKSLDYEALKKDLRALMTDSQDWWPADFGHYGGLFIRMAWHSAGTYRVFDGRGGAGQGQQRFAPLNSWPDNVSLDKARRLLWPIKQKYGNKISWADLMILTGNVALESMGFKTFGFAGGRPDTWEADEATYWGRETTWLGNDARYAKGFSGSDKRGTLIADEDSHKTTHSRELETPLAAAHMGLIYVNPEGPDGNPDPIAAAHDIRDTFGRMAMNDEETVALIAGGHTFGKTHGAAPADNVGKEPEAAGLEAQGLGWANKHGSGKGPDTITSGLEVTWTKTPTQWSNNFLEYLFKFEWELTKSPAGAHQWVAKNADEIIPHAYDASKKRKPTMLTTDLSLRFDPAYEKIARRFLEHPDQFADAFARAWFKLTHRDMGPRARYLGPEVPSEVLIWQDPIPAVNHPLVDASDIATLKDEILASGVPFRSFISTAWAAASTFRGSDKRGGANGARIRLAPQRDWEANNQPWLREALSALEAVQSRFNSRGDGKKVSLADLIVLAGCAAVEKAAQDAGHPIKVPFVPGRMDASQEETDVQSFSHMEPFADGFRNFAKGPARPRAEHYLVDKAQLLNLSAPEMTVLVGGLRVLNTNYDGSAHGVFTSRPGALSNDFFVHLLDMNTAWKDAGNGELFEGSDRKTGGKKWTATRADLVFGSNAELRAIAEVYASNDGDMKFVKDFVAAWNKVMNLDRFDLKGKQTIPARL
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APC7_ARATH
Sequence: MEVPKEQIATLIEHGLYDSAEMLGCFLVSSPTVSAETSPQLKAENLILLGDALFHQREHRRAIHTYKQALHHYTRIPKQSSGISRSSLSLSTRSSVNASSISAINENEVRFKIASSHFALNETKAAIAEMESVKTRSLEMNILMAKLHRNSGYNRGAIAFYKECLRQCPYVLEAVIGLAELGVSAKDIISSFTQTSNRSAKVSLDQIDPTRWLQRYVEAQCCVASHAYKGALELFAELLQRFPNNVHLLTETAKVEAIIGKNDEAIMRFEKVRSIDPYTLTSMDEYAMLLQIKCDYSRLNKLVHDLLSVDHTRAEVFVALSVLWERKDARTALSYAEKSIRVDERHIPGYIMKGNLLLQAKRPEAAAIAFRAAQNLRSDLRSYQGLVHSYLAFGKTKEALYTAREAMNAMPQSAKALKLVGDVHAFTSSGREKAKKFYESGLRLEPGYLGAVLALAELHLMEGRNGDAVSLLERYLKDYADDSLHVKLAQVFAATNMLQDSLSHFQAALRINPQNEAAKKGLDRLEKQMKGIDPDATDENDENDVEDVDGDTEEAELM
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins.  The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation.  Involved in the control of endoreduplication (By similarity).
What are the official names of this protein?
Anaphase-promoting complex subunit 7, Cyclosome subunit 7.
What is the protein family that this protein belongs to?
Belongs to the APC7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BZLF1_EBVG
Sequence: MMDPNSTSEDVKFTPDPYQVPFVQAFDQATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSAAPTGSWFPAPQPAPENAYQAYAAPQLFPVSDITQNQLTNQAGGEAPQPGDNSTVQPAAAVVLACPGANQEQQLADIGAPQPAPAAAPARRTRKPLQPESLEECDSELEIKRYKNRVASRKCRAKFKHLLQHYREVASAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDLLNF
What is the function of this protein?
Transcription factor that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle.  Mediates the switch from the latent to the lytic cycle of infection in cells containing a highly methylated viral genome.  Probably binds to silenced chromatin and recruits host chromatin-remodeling enzymes.  Regulates this switch by binding to 2 types of ZEBRA response elements (ZREs): the CpG-free AP-1 like elements (latency) and the methylated CpG-containing elements (lytic replication).  Activates preferentially the methylated forms of the viral lytic R (BRLF1) and Na (BRRF1) gene promoters, the latters being the first genes activated during Z-mediated reactivation in latently infected cells.  BZLF1 and BRLF1 act together to trigger lytic replication.  Also binds the lytic origin of replication, oriLyt.  Induces G1 cell cycle arrest by stabilizing the host CCAAT/enhancer binding protein CEBPA.  This function is important because the lytic cycle preferentially takes place in host cells arrested in G1.
What are the official names of this protein?
Lytic switch protein BZLF1, EB1, Protein Z, Trans-activator protein BZLF1, Zebra, Zta, bZIP transcription factor ZEBRA.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: NVD_XENLA
Sequence: MESVGHSLLTLSVLCPVGALLLCWVGSVLLGAGLLPSLTLSTRDPSTTLSRTPWLVVLVPLLVLWGWRWLSRPMELLRSPEEVGYIPERGRSRAQTANLVRRRRMKGELPPIYPNGWYRALDSHLLPPGTVQDCTLLGEQLAVYRTLEGKVYVVDAYCPHLGANLAVGGKVVGDCIECPFHGWQFRGEDGKCTRIPYAEKVPDFAKIKTRPSCELNGMVFVWYHCDGIEPTWSVPEQEEITKKEWVYHGRTEHYVNAHIEEIPENAADIAHLDFLHTPGILSGVDLRYTKSRIWDFVKHSWKVQWIPEPAPNKHCSQMLLAHSILLFGKHFPLLDVNVVARQVGPGIVFLHFKHAFLGEGVIVHCVTPVEPLLQKVSHSIYYQKNIPALIPKFILKAECIQFERDVMIWNNKKYISKPMLVKEDAAIQKHRRWFSQFYSNNSPQITFQQEGLDW
What is the function of this protein?
Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol.  This reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid.
What are the official names of this protein?
Cholesterol 7-desaturase nvd, Protein neverland, Nvd protein, nvd-Xl.
What is the protein family that this protein belongs to?
Belongs to the cholesterol 7-desaturase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CHEV3_HELPY
Sequence: MAEKTANDLKLSEIELVDFRIYGMQEGVPYEGIYGINVAKVQEIIPMPTLFEYPTNLDYIIGVFDLRSIIIPLIDLAKWIGIIPDKSKENEKIVIITEFNNVKMGFLVHSARRIRRISWKDVEPASFSASNSINKENITGTTRIENDKTLLILDLESILDDLKLNEDAKNAKDTHKERFEGEVLFLDDSKTARKTLKNHLSKLGFSITEAVDGEDGLNKLEMLFKKYGDDLRKHLKFIISDVEMPKMDGYHFLFKLQKDPRFAYIPVIFNSSICDNYSAERAKEMGAVAYLVKFDAEKFTEEISKILDKNA
What is the function of this protein?
Plays a role in chemotaxis signal transduction system in order to colonize the host stomach.  May act as a phosphate sink to control the flow of phosphate to CheAY.
What are the official names of this protein?
Chemotaxis protein CheV3.
Protein: PYRF_SULDN
Sequence: MQLCVALDLPTKEENLELIGKIKDYDVWLKVGLRSYIRDGEDFLKDIKKINPDFKIFLDLKLYDIPNTMADAAESIISLGVDMFNVHASAGKRAMREVMVRLERYEKRPIVLAVTALTSFNEDEFGKIYGDSISKKADQFAKDAYESGLDGVVCSAYESSSIKNITNRDFMTLTPGIRPFGEDSGDQQRVADVAFAKNAHVDFIVVGRPIYNSKNPAEVIRRILEQI
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: NDB2_MESEU
Sequence: MNKKILLVIFIVTMLIVDEVNSFKFGSFIKRMWRSKLAKKLRAKGKELLRDYANRVLSPEEEAAAPAPVPAKRRR
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Meucin-49, Venom antimicrobial peptide, VAMP-1.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Long chain multifunctional peptide (group 2) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP22_ASHGO
Sequence: MRRAGFQASSLLGRICSSGLNCKKLTVAFSSNEHMAMSSWAGDLGRRIGTQLYRRENVAELRRLQAELQQQWTAAGDGRARAELEACARDEEERAFFRLLMPASGPEVTQRLEEAVKEVLGGRSSRAEKRERLYCAIALVARENAGRGIEVPEAAHRWFAADLGRNEYFGHMQFLIEHGVQLNAPAAFQLVRTMLRSGSELEVQLVSFKLFLYDTESRRVFEEKFDRVYDFMRMHYVITQMVVRRDFRFMRDYLEVLARRLEQHELCDARMSAAVQRDHIARYTELLMLYARKSGDEKMLAELFASLVDSLPRGMGGATLRQPLHEVMTYLISENQPQQVLKLVAGMRKAEPNRRPGKSSVPGTLALVVSALRQFNNPNLVVSFIVQAYRKTQTRVLLGQLGLWSLAFYGRAVALSPEAAKSPQELAQISPVDLPKELILKSVPDSCIMCELYQAILSEKRSQVPAEEYREILIQLFALYQDFMGKLVHKYDYYHLYDTSVLRLLLYKIKNEVGDGELAFKLLMDFYGQPKMRPKCTAEGNPFGVVLYQNNAITQTQLNQALALMGGLRIPMDFKTTSSMVLWYASAGDIDLAHTWYTKLVRGRFQMKNRRVLKLALAHGWTIPAYADQQLVSELSRADNSSDGPEHTQEAVETAVLESEEASACTSIIIEKADELLHKIQQTRPLDPPSDTRSAAP
What is the function of this protein?
Translation factor specific for subunit 6 of the mitochondrial ATPase.  Required for assembly of the CF(0) component of the ATPase (By similarity).
What are the official names of this protein?
Mitochondrial translation factor ATP22.
What is the protein family that this protein belongs to?
Belongs to the ATP22 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: PRDX3_DROME
Sequence: MSFVARSLIRNVPLMGKAILSQQKQIAARLLHQTAPLAAVRVQQPAPDFKGLAVVDNSFQEVKLEDYRGKYLVLFFYPLDFTFVCPTEIVAFSERIKEFHDINTEVLGVSVDSHFSHLTWCNVDRKNGGVGQLKYPLLSDLTKKISADYDVLLDKEGISLRGTFIIDPNGILRQYSINDLPVGRSVDEVLRLIKAFQFVEQHGEVCPANWNPNSNPATIKPDVEESKKYFSKHG
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:11677042).  Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:11677042, PubMed:20869434, PubMed:23124252).  May be involved in aging-associated changes in the responsiveness to oxidative stress (PubMed:23124252).  Involved in the maintenance of global thiol redox homeostasis (PubMed:20869434).  Functions in the central nervous system (CNS) and in motor neurons and is essential for normal motor function (PubMed:33889951, PubMed:33585478).
What are the official names of this protein?
Thioredoxin-dependent peroxide reductase, mitochondrial, Peroxiredoxin 3, Thioredoxinperoxidase 3.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.