PharMolix/UniProtQA huggingface dataset:
Protein: TVB71_HUMAN
Sequence: MGTRLLCWAAICLLGADHTGAGVSQSLRHKVAKKGKDVALRYDPISGHNALYWYRQSLGQGLEFPIYFQGKDAADKSGLPRDRFSAQRSEGSISTLKFQRTQQGDLAVYLCASSS
What is the function of this protein?
Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447).  Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
Probable non-functional T cell receptor beta variable 7-1.
What are the subcellular locations of this protein?
Cell membrane.
Protein: TR1L1_HUMAN
Sequence: MGLRKKSTKNPPVLSQEFILQNHADIVSCVGMFFLLGLVFEGTAEASIVFLTLQHSVAVPAAEEQATGSKSLYYYGVKDLATVFFYMLVAIIIHATIQEYVLDKINKRMQFTKAKQNKFNESGQFSVFYFFSCIWGTFILISENCLSDPTLIWKARPHSMMTFQMKFFYISQLAYWFHAFPELYFQKTKKQDIPRQLVYIGLHLFHITGAYLLYLNHLGLLLLVLHYFVELLSHMCGLFYFSDEKYQKGISLWAIVFILGRLVTLIVSVLTVGFHLAGSQNRNPDALTGNVNVLAAKIAVLSSSCTIQAYVTWNLITLWLQRWVEDSNIQASCMKKKRSRSSKKRTENGVGVETSNRVDCPPKRKEKSS
What is the function of this protein?
Stimulatory or required for the translocation of secretory proteins across the ER membrane.
What are the official names of this protein?
Translocating chain-associated membrane protein 1-like 1.
What is the protein family that this protein belongs to?
Belongs to the TRAM family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RSMF_SHESR
Sequence: MVQLNQNFINTIAQELPAHLSMDDFIAACSRPLRRSIRVNTLKISSEDFKQLMLPKGWTFEPIPWCEDGFWISYDEEEQLGNALEHIQGLFYIQEASSMLPPTALFTPNADWQCVLDLASAPGSKTTQMAALMNNQGLLVANEYSASRVKVLHANVLRMGASHCALTHFDGRVFGEYLYESFDAVLIDAPCGGEGTVRKDADALKSWSLDEVLEISETQKALIESAFLALKPGGSLVYSTCTLNRHENQGVCEYLQQTYGDAVQFESLSQLFDGAEKATTPEGFLHVWPQIYDSEGFFVAKLTKTRSVPRLQPEPKLQKNFPFTEASAKQAKAIQAYFADDLGIKLPDDLIMVRDDEFWLFPHEFRDFIGKMRFQRIGVKLADHSKHGFKVRHEAIIALAGKALTAGAANGAKVVDVSDEQAKEYLMGRDIPLDTAGKAQGEVIVCYGGAPLGMAKHLGNKLKNSLPRDLVKDKVLLLPPQA
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_SALTY
Sequence: MLIKLLTKVFGSRNDRTLRRMRKAVSLINAMEPEMEKLSDDELKAKTNEFRARIEKGESVESLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALSGKGVHVVTVNDYLAQRDAENNRPLFEFLGMSVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKKVNKIIPHLIRQEKEDSDTFQGEGHFSVDEKARQVNLTERGLVLIEELLVQEGIMDEGESLYSPGNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTANGQPVLVGTISIEKSEVVSRELTKAGIKHNVLNAKFHANEAGIVAQAGYPAAVTIATNMAGRGTDIMLGGSWQAEVAALEAPTEEQIAQIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYTQRNELLDVSDVSDTINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLEMPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFAMFAAMLESLKYEVISTLSKVQVRMPEEVEAMEMQRREEAERLAQMQQLSHQDDDAAVAADLAAQTGERKIGRNDPCPCGSGKKYKQCHGRLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: NOP10_SULTO
Sequence: MKWKIKKCPKDCTYTLKDICPICGTPTIIPHPARFSPVDKYVKYRIEIKKGIKLNC
What is the function of this protein?
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
What are the official names of this protein?
Ribosome biogenesis protein Nop10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
Protein: FBD19_ARATH
Sequence: MDRISGLPDELLLRVLSLLPNVKDVVVTMVLSKRWQFLWMMVPKLVYDDSYQNLEYGKFSRFVDRSLFMRKAPGIETLHFKLGQNCGNGDIQWWIRAASKFCFRELIIEINCSTSASPSILPRSLYTECRMLVTLKLKKAVLVDVSSPTCFPSLKNLSLVSVKYPGNEFVKSLLSSCHVLEDLVVEQCINDNVTIFSVKVPSLKSLVLRTSKERAPDGESGFVVEAPSLEYLDIDQTGGFCVIENGMPNLAEAYVSVLHHHPVKFLSSITSVKRLYLCLLPHSILSCMQDMYPIRCVFHRLVHITLCTCDDEWLNLLACLLKGSPKLISLKLEKHHGHLICSPSPLRDDLSSVPECVLSSLETVEWVDYEGTEAERQLVEFILRNGSCLKKFVISPESVNPDKKYEMI
What are the official names of this protein?
Putative FBD-associated F-box protein At5g50270.
Protein: IL21R_HUMAN
Sequence: MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS
What is the function of this protein?
This is a receptor for interleukin-21.
What are the official names of this protein?
Interleukin-21 receptor, IL-21 receptor, IL-21R, Novel interleukin receptor.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 4 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RS5_GRABC
Sequence: MAREPREGRGGREREADDIIDKLVTINRVAKVVKGGRRFAFAALVVVGDQKGRVGYGAGKAREVPEAIRKATERAKRSMIRVPMKEGRTLHHDVYGHFGAGKVVLRSATAGTGIIAGGPMRAVFESLGIGDVVAKSLGSRNPHNMVKATFAALERCSSPRSVASRRGKKVSDILGRREPVAGQEGEEAHA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: ILVY_SALTI
Sequence: MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRHTLDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQVSVDKPDWSTVPFIMADQGPVRRRIELWFRRHKISNPQIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIDAFWKILPN
What is the function of this protein?
This protein activates the transcription of the IlvC gene in the presence of acetolactate or acetohydroxybutyrate.  IlvY is also a negative regulator of its own expression (By similarity).
What are the official names of this protein?
HTH-type transcriptional activator IlvY.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPE1_RHORU
Sequence: MLDAPAGRWPDPDAGEGALRRLLDGEGKDLVIDRALLRWAAERGKGPYPRAERTARWRALIETALGWTAPTFPLGGRDALACGLKGPAVGEAWRPCADAGLRAAARPGGTRCWPGSPLGGTGPPTNRPPRSRAWNRYRSDRPSPGGVLRPACGMAQGLAEHQGGGDGDVERAHAGNHRNPDAQVGALVDLGGNARALSAQQQHVVGLKVSFGMKRARLRCQQDQAGFVGEPRDEIRPGRMTHKSGAFEIVHSGAA
What are the official names of this protein?
Uncharacterized 28 kDa protein in petA 5'region.
Protein: KITH_UREP2
Sequence: MAKVNAFSKKIGWIELITGPMFAGKTAELIRRLHRLEYADVKYLVFKPKIDTRSIRNIQSRTGTSLPSVEVESAPEILNYIMSNSFNDETKVIGIDEVQFFDDRICEVANILAENGFVVIISGLDKNFKGEPFGPIAKLFTYADKITKLTAICNECGAEATHSLRKIDGKHADYNDDIVKIGCQEFYSAVCRHHHKVPNRPYLNSNSEEFIKFFKNKKRNKNI
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAL_NEIMB
Sequence: MTILSDVKALGQQIWLDNLSRSLVQSGELAQMLKQGVCGVTSNPAIFQKAFAGDALYADEIAALKQQNLSPKQRYETMAVADVRAACDVCLAEHESTGGKTGFVSLEVSPELSKDAQGTVEEARRLYAAIGCKNAMIKVPATDAGIDALETLVSDGISVNLTLLFSRAQTLKAYAAYARGIAKRLAAGQSVAHIQVVASFFISRVDGALDTTLPDHLKGKIAIALAKAAYQDWAQYFGSPEFAALETKGANRVQLLWASTGVKNPAYPDTLYVDSLIGAHTVNTVPDATLKAFIDHGTAKATLTEGVEEAQAQLAETAALGIDVETLATRLQEDGLKQFEEAFEKLLAPLA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACHA2_CHICK
Sequence: MGWPCRSIIPLLVWCFVTLQAATREQKQPHGFAEDRLFKHLFTGYNRWSRPVPNTSDVVIVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPEDFDNVTSIRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSNGKVKWVPPAIYKSSCSIDVTYFPFDQQNCKMKFGSWTYDKAKIDLENMEHHVDLKDYWESGEWAIINAIGRYNSKKYDCCTEIYPDITFYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPSTHTMPHWVRSFFLGFIPRWLFMKRPPLLLPAEGTTGQYDPPGTRLSTSRCWLETDVDDKWEEEEEEEEEEEEEEEEEKAYPSRVPSGGSQGTQCHYSCERQAGKASGGPAPQVPLKGEEVGSDQGLTLSPSILRALEGVQYIADHLRAEDADFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPYLAGMI
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RL1_SYNJB
Sequence: MARKLSKRMQALREKVKPIAYAPEAALALMKETATAKFEEAAEVHIRLGIDPKYADQQLRTTVVLPRGTGQEIRVAVIARGEKVVEAQNAGADRVGYEDLIEEISKGMMDFDLLIATPDVMPQVAKLGRLLGPRGLMPSPKGGTVTMDLAQAIKEFKAGKLEYRADRTGIVHLIFGKCKFPVEALLENLKAVQESIDRNRPSGAKGKYWRTLHVSATMGPSIEVDINALRELKLAT
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: IRAM_ECO7I
Sequence: MKWIVIDTVIQPTCGISFSAIWGDMKMIIWYQSTIFLPPGRIFTPVKSGIILKDKEYPITIYNIAPFNKDLWSLLKSSQECPPGESKITNKCLHNSCIIKICPYGLK
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation.
What are the official names of this protein?
Anti-adapter protein IraM.
What is the protein family that this protein belongs to?
Belongs to the IraM/RssC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLDC1_ARTBC
Sequence: MEVGRFASKSASMTYLLLVLLVGFILPQQGQHAHARTLARRDNSPTDICKRWSQQTAIVNGTLYIYGGRSTTDASQKDNTWNDNFLTLDLKSSWGISAPKLTGLPRGDNGPPPVSNGYLWNSFSSLFLYGGEFSDNPATEPVDFSLWEYSIPSSSWIEHKSPKTSSGENSAEANIPVQRSAEGAGINVPDLGRGWYFGGHLDGYTTKGWSQSIPRVYLKSMIEYTFPGHTNNGVKINTDDKRAGPEGVWRNITEGGLQDSAGFTERADGVLVYIPGFGKEGIILGLAGGTNATFTQMNVIDVFDIASSKWYKQATSGKTPKIRVNPCAVAASAADGSSTQVYLFGGQNLIPYGEQIQYNDMWILSIPSFTWIEAKTDGQSVPPARAGHTCNIWNSQIVVTGGYVGQDLSCDSPGIYVFDASELTWKNQYTALEGGNDLNQQASQTRDSSGLGGSYGYRVPKVVQSVIGGDETGKATQTVPAVAPTDGPLATGQPLTYTVLPTAGSGPHAGSPGSGSDGPNIAAIVAGVIAGCLGVLAIYLGFVTWLYRRRLAIYKSHLAATQRSSIGSYGDKISSFPPRYSDHMSSSGLGTTGSTGNLTVTTARMSWISGDNQRHNHTRSSSGGNFDHLAQPERPSTSSSVEDLLAGQEPTFLGVMLNPRQTLRVINQ
What are the official names of this protein?
Kelch repeat-containing protein ARB_01230.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Secreted.
Protein: SFSA_AERPE
Sequence: MAVELRYDEEAVFLRRVNRFVVEVKSSRGVVRCHLMDTGRIDHLASPGRRGVLIAWLNRLGGKTVCRAQAFKTAGGVVAVVDSRVPNRLFAEAAPMVVGGDASIEAEREVFGSRLDFLISTGRGLWAVEVKGVNLSLDGVGLFPNAPSARAVKHLEVLARLAREGVKPLMAFVALRPDIRVFAPNYRVDRRFASLACTLLRRGLVGMVGIRVSIDLEPGVVRIRPVATAPVQCPPLQPGR
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: CH10_BRUO2
Sequence: MADIKFRPLHGRVIVRRVESEAKTAGGIIIPDTAKEKPQEGEVVAAGAGARDEAGKLVPLDVKAGDRVLFGKWSGTEVKIGGEDLLIMKESDILGIVG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2RY3_CHICK
Sequence: MSMANFTGGRNSCTFHEEFKQVLLPLVYSVVFLLGLPLNAVVIGQIWLARKALTRTTIYMLNLAMADLLYVCSLPLLIYNYTQKDYWPFGDFTCKFVRFQFYTNLHGSILFLTCISVQRYMGICHPLASWHKKKGKKLTWLVCAAVWFIVIAQCLPTFVFASTGTQRNRTVCYDLSPPDRSTSYFPYGITLTITGFLLPFAAILACYCSMARILCQKDELIGLAVHKKKDKAVRMIIIVVIVFSISFFPFHLTKTIYLIVRSSASLPCPTLQAFAIAYKCTRPFASMNSVLDPILFYFTQRKFRESTRYLLDKMSSKWRQDHCISYGS
What is the function of this protein?
Receptor for extracellular ADP > UTP > ATP = UDP.  The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
P2Y purinoceptor 3, P2Y3, Nucleoside diphosphate receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FP_NPVOP
Sequence: MDRFEQLINVALLKSLINTQIDESDDIKSMNVKLKELERDRLNDSVEIYGVHDARLGSKKMRTYYLKKICALLDLDFKHVLDSAFHKNHMVVKLSDSARAKEWQSKSRERRLKNHSLGIDYDGPVKIFVAAPPEQKLLLKKARDALLPVYKYISICKHGVMVRRDEKSRVFIVKDEQHINYLKTNDLFAFDKAGAFRADGQRMLENII
What are the official names of this protein?
FP protein.
Protein: APT_PSEF5
Sequence: MAFDSFDIKSLIRPVIDFPKPGVIFRDITPLFQSPRALRLVADSFAQRYVEEDFSHIGAMDARGFLIGSIIAYQLNKPLILFRKQGKLPADILAEGYRTEYGEAFIEVHADSLCEGDSVLLIDDLIATGGTLIAAANLVRRMGAKVYEAAAIIDLPELGGSQKLQDMGIPTFCLTQFSLTER
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BECN1_XENTR
Sequence: METSKSSTMQVSFVCQRCSQPLKLDTSFKILDKVTMQELTAPLVTTAAVKPGDIQEVDSNIEETFAENRTDGVSRRLIPPARMMSTESATSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCLEILERMNEDDKEKLEAKLKELAEDEDRLIQELEEVERNRELVAKDIEKVREEAERLEQEEARYQKEYSEFKRQQLELDDDLKSVENQMRYAQIQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLQFQRYRLMPFGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGDTGFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
What is the function of this protein?
Plays a central role in autophagy (By similarity).  Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity).  Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity).  Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (By similarity).  Involved in endocytosis including endosome formation in neuronal cells (By similarity).
What are the official names of this protein?
Beclin-1.
What is the protein family that this protein belongs to?
Belongs to the beclin family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome.
Protein: UNG_VIBC1
Sequence: MNQLPTWHDVIGEEKQQSYFVDTLNFVEAERAAGKAIYPPAKDVFNAFRFTEFNDVKVVILGQDPYHGPNQAHGLCFSVLPGIKTPPSLVNMYKELAQDIEGFQIPQHGFLQSWAEQGVLLLNTVLTVEQGKAHSHSKTGWETFTDRVIEAINQHQEGVVFLLWGSHAQKKGRFIDRNKHHVLTAPHPSPLSAHRGFFGSKPFSQANQILVQQGKEVINWHLPMTV
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS24_HUMAN
Sequence: MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKPKE
What is the function of this protein?
Component of the small ribosomal subunit (PubMed:23636399).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).  Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (PubMed:18230666).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
What are the official names of this protein?
40S ribosomal protein S24, Small ribosomal subunit protein eS24.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: PCDGI_PANTR
Sequence: MGGSCAQRRRAGPRQVLFPLLLPFFYPTLCEPIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARKLRVSAEKLHFSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSNPYFSLMVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNHYYKLVTDGALDREQTPEYNVTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFADNLQEILPDLSDRPVLSDPQAELQFYLVVALALISVLFLLAVILAIALRLRRSLSPTTWDCFHPGLCVKSGPVVPPNYSEGTLPYSYNLCIAHTGTKEFNFLKCSVPLHSNEDMVCSVSPGALIPPHGGEDLTSHPETLTSQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin gamma-B6, PCDH-gamma-B6.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: M3112_BOMMX
Sequence: MHFKYIVAVSFLIASAYARSVQNDEQSLSQRDVLEEESLREIRGIGGKILSGLKTALKGAAKELASTYLHRKRTAEEHEVMKRLEAIMRDLDSLDYPEEASERETRGFNQDKIANLFTKKEKRILGPVLGLVGSALGGLIKKIG
What is the function of this protein?
Maximin-H11 shows antimicrobial activity against bacteria and against the fungus C. albicans.  Shows strong hemolytic activity (By similarity).
What are the official names of this protein?
Maximins 3/H11 type 2.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPG_PICAN
Sequence: MPAASKNVVMIDNYDSFTWNLYEYLCQEGANVEVFRNDQITIPEIEQLKPDVVVISPGPGHPRTDSGISRDVISHFKGKIPVFGVCMGQQCIFEEFGGDVEYAGEIVHGKTSTVKHDNKGMFKNVPQDVAVTRYHSLAGTLKSLPDCLEITARTDNGIIMGVRHKKYTIEGVQFHPESILTEEGHLMIQNILNVSGGYWEENANGAAQRKESILEKIYAQRRKDYEFEMNRPGRRFADLELYLSMGLAPPLINFYDRLEQNISAGKVAILSEIKRASPSKGVIDGDANAAKQALNYAKAGVATISVLTEPTWFKGNIQDLEVARKAIDSVANRPCILRKEFIFNKYQILEARLAGADTVLLIVKMLS
What are the official names of this protein?
Multifunctional tryptophan biosynthesis protein.
Protein: RNH_MARMM
Sequence: MSTITIHTDGACSGNPGPGGWGAILEWNGHRKELKGGEADTTNNRMEMMAAIQALEALRKADRSVILITDSVYLRDGITKWIHGWKKRGWKTADKKPVKNVDLWQRLDELTRSHTIDWRWVKGHAGDPGNERADELAREGLAEARGRQP
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_MOOTA
Sequence: MPGNIVLIGFMGSGKTTVGRLLARDLGWSFLDTDTMVEERLGLPVKEIFAREGEEFFREVEKEAVARVATARQAVIATGGGAVLCGVNVKLLREGNKVVWLQVRPETALKRAGLDDSRPLLQGREPRDIAALLRRREPYYAFADIYIDTDGKEAAAVAREIKEALKAWLESLT
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.