PharMolix/UniProtQA huggingface dataset:
Protein: EFGM_USTMA
Sequence: MVAIPRVAAARSLARQLARQSLRTTSFASAPVRIAIASTPLARSPSSFRSLSSSTRRSAAAAAAAAAAKATPAHDDSHTPMAVLTEADLGRLVRQRNVGISAHIDSGKTTLTERVLFYTGRIKDIHEVRGRDAVGAKMDHMELEREKGITIQSAATYCSWKATPPTEKASVSGDAANVESKELMEKKQDFHINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVSGVQSQTITVDRQMRRYSVPRISFINKMDRAGANPWRVIGQIRNKLKMPAAAVQIPIGAEDDFNGVIDLIRWKAVYNEGHKGIDIRETDEIPAEYLELAKQKRAELIEQLAEVDDEMTEMFIEEREPTIEELAAAIRRTTIRCQFSPVFLGSAIKNKGVQAMLDGVCSYLPNPAEVPATAMDMSSAATKKAAEEAAQAAGEDQEAAAEARKNAAPPVLPLSPASEAPLVGLAFKLEEGKYGQLTYMRVYQGTLKRGNLIFNARTGKKVKVPRLVRMHSNDMEDVDEIGAGEICAMFGVECSSGDTFTDGTTQLSMTSMFVPEPVISLAITPEGKESQNFSRALNRFQKEDPTFRVHVDKESNETIISGMGELHLEIYVERMRREYNVPCTTGKPRVAFRETIEKKATFAYTHKKQTGGAGQFGRVMGYIEPMEVDPETGVDTAFDNRVVGGSIPNGYISACEKGFYDALEKGALSGHAVTGVRFVLEDGAAHSVDSSELAFRLATAGAFREAYQKANPVILEPKMTVEVVAPIEFQGAVIGALNQRKGTISDTEVREDEFTLTAEVSLNDMFGYSSQLRGLTQGKGEFSMEYKCHTPVMMNIQKEMHEAYRKKQTEKK
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EPD2_CANMA
Sequence: MISVIKSLLTLSVLSTLAAAKFESATPPIEVVGNKFYYSNNGTQFLLRGIAYQQDTSGSVSNGYDSDPNRKYNDPLADADACKRDVQYFIDTNTNTLRVYGIDPDKDHEECMKIFSDAGIYVIADLSEPTVSVNRINPEWNLDLYERYTKVIDNMQEYSNVLGFFAGNEVTNNRTNTDASPFVKAAVRDMKKYIKDNDYRTIPVGYSSNDDEDTRVAIADYFACGSLDDRADFFGINMYEWCGRSTFATSGYKDRTEDFKNLTIPIFFSEYGCNEVSPRVFQEVGTLYSDQMTDVWSGGIVYMYYEEANHYGLVSLNGDRVSTLADYNNYKSAIKSISPSLARRSTIQSEDSTKTMACPDNSHSTWRASTELPPTPDEEFCDCISQSFNCVVADDVDAEDYSTLFGEVCGYIDCGDISANGNTGEYGGFSFCSDKDRLSYVLNQYYHDQNERADACDFAGSASINDNASASTSCSAAGGRGLQSGRRSSTTRGGSSSSRSSSSSSSSSTGSGSSNAGIKVGGGQMSTVKLITITTIVTAFVGGLSIIFY
What are the official names of this protein?
Protein EPD2, Essential for pseudohyphal development 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 72 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: DYR_SCHMA
Sequence: MRLNVVVAVSENWGIGKGGGLPWKIKKDMEFFKTVTTKAHPGLKNAVVMGRVTWESIPESFKPLKDRINIVVSSTLSHAPSFVQVVPSLNAAIDLLYNEEFSSIVDEVFIIGGYRLYKEALKQSIYPVRIYCTHILSEVDCDTYFPKVDWDKLKKVDLPDIPADTFTENGFTFKFCVYDVPSEQFI
What is the function of this protein?
Key enzyme in folate metabolism.  Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: HLDE_RHOPA
Sequence: MFSFDALLQAIARQTVLCVGDLMLDEFVYGEVSRISPEAPAPVIAVQRSETNIGGAGNVARNIAAIGARCIFVGLIGDDATGRFLESELGSESRIEPVLVCDGSRPTTRKVRFVSEHFSTHMLRADWETASPAAADIEQRLLDAILPQLARADIVLLSDYAKGVLTARVIRDTIDAAKKLGKRVIVDPKSANFAIYRGATLLTPNRKEFTAATRSAAATDDEIAAAAQDAMALAECEAMLVTKSEHGMTLVPRGGEPIHVPALPVKVRDVSGAGDTVAAVLAVVLASGANWATAMRAASAAAAVAVSKNGTAVVTPAELRRRILPHASLAAEEKIIGSDEELDERLKQWRREGLRVGFTNGCFDILHPGHVKVLTAARGACDRLIVGLNSDASVRRLKGESRPVQHERARAEVLAALEAVDLVAIFEEDTPLRLITRIEPSVLVKGGDYTREQVVGHEIVAAKGGDVLLVDVLPGFSTTSLVARAREGQS
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: TRPA_HELPH
Sequence: MRYQNMFETLKKQDKMAFIPFVTLGDPNYEWSFEIIKTLIDSGVSALELGFAFSDPVADGVTIQASHLRALKHASMAKNFQLLRALRDYNPHIPIGLLAYANLIFSYGVDGFYAQIKECGVDSVLIADMPLIEKELVIKSAQKHQIKQIFIASPNASVKDLEQVATHSQGYIYTLARSGVTGASHTLKNDASAIIKTLKTFSSTPALLGFGISKKEHITNAKGMGADGVICGSALVKIIEENLNNENAMLEKIKGFIGGMIF
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RRG9_PYRTT
Sequence: MSCHNCSRTALGLFIRSLTNLQPTFAARRPLIHPQPLRFLSDARRPRKVESVSRPDGVNPDTEIEDTLSGEGFPNKRERPAWAIQKEALKEKLGGEAWNPRKKLSPDTMEGIRHLNSTQPDKFTTPVLAEHFKVSPEAIRRILKSNWKPSDKEYEERMERWNKRGERIWSNLVEMGVKPPKRWRDMGVGRARDGNVPRWKSTERNLVDVKDSASSDFTNYIPDEDIIPTVGKDGKSKPITSSIPLSERL
What is the function of this protein?
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
What are the official names of this protein?
Required for respiratory growth protein 9, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG9 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ISPF_CERS1
Sequence: MDIRTGNGFDVHAFGPGDHVWLCGVRVPHHRGLIGHSDADVGMHALTDAIYGALAEGDIGVHFPPSDPQWKGAASRIFLEHAMGRIAARGYTLANCDVTLICERPKIGPVAPAMREALAEIMGIAADRISVKATTSEKLGFTGREEGIAAIATVALLQA
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: Y2663_BACCN
Sequence: MEYQYPLDYDWSNEEMITVVKFYEAIERANEKGIVKEELMDLYRKFKQIVPSKAEEKKIDKEFQEVSGYSIYRTIQKGKDTEEHKIVKM
What are the official names of this protein?
UPF0223 protein Bcer98_2663.
What is the protein family that this protein belongs to?
Belongs to the UPF0223 family.
Protein: CDK13_HUMAN
Sequence: MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY
What is the function of this protein?
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing.  Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation.  Required for RNA splicing, probably by phosphorylating SRSF1/SF2.  Required during hematopoiesis.  In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
What are the official names of this protein?
Cyclin-dependent kinase 13, CDC2-related protein kinase 5, Cell division cycle 2-like protein kinase 5, Cell division protein kinase 13, hCDK13, Cholinesterase-related cell division controller.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: TXVE_BOTJA
Sequence: MAVYLLAVAILFCIQGWPLGTVQGQVMPFMEVYRHSVCQPRETLVSILEEYPGEISHIFRPSCVTALRCGGCCTDESLECTATGKRSVGREIMRLSPHKGTSEKEVMQFTEHTDCECRPRSASGVNSRKHKRNPEEGEPRAKFPFV
What is the function of this protein?
Snake venom VEGFs that may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension.  This protein induces an increase in capillary permeability after intradermal injection, as well as a drastic hypotensive effect after intravenous injection (By similarity).  The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase.  Also induces angiogenesis in vitro (By similarity).  Like other crotalid VEGFs, this protein interacts with VEGF receptor-1 (FLT1) with a high affinity, whereas it binds to VEGF receptor-2 (KDR) with a low affinity (By similarity).
What are the official names of this protein?
Snake venom vascular endothelial growth factor toxin, svVEGF, VEGF-F.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family. Snake venom VEGF subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL2_BACC1
Sequence: MGIKKYNPTTNGRRNMTTNDFAEITTDRPEKSLLAPLSKKAGRNNQGKITVRHQGGGHKRQYRIIDFKRNKDGIPGRVATIEYDPNRSANIALINYVDGEKRYILAPKNLEVGMEIMSGAEADIKIGNALPLINIPVGTVVHNIELKPGRGGQLVRSAGTSAQVLGKEGKYVLVRLTSGEVRLVLSACRATVGQVGNESHELIKIGKAGRSRWLGKRPTVRGSVMNPVDHPHGGGEGRSPIGRKSPMSPWGKPTLGFKTRKKNKASDKFIVRRRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: Y2277_MYCTO
Sequence: MVKTAMLGAVALVIALGGTCGVADALPLGQTDDPMIVAHRAGTRDFPENTVLAITNAVAAGVDGMWLTVQVSSDGVPVLYRPSDLATLTDGAGPVNSKTVQQLQQLNAGWNFTTPGVEGHPYRQRATPIPTLEQAIGATPPDMTLFLDLKQTPPQPLVSAVAQVLTRTGAAGRSIVYSTNADITAAASRQEGLQVAESRDVTRQRLFNMALNHHCDPQPDPGKWAGFELHRDVTVTEEFTLGSGISAVNAELWDEASVDCFRSQSGMKVMGFAVKTVDDYRLAHKIGLDAVLVDSPLAAQQWRH
What are the official names of this protein?
Uncharacterized protein MT2337.
Protein: MRAZ_POLSJ
Sequence: MFQGASSLALDTKGRLSVPTRHRDVLSATASSQLTITKHPHGCLMIFPRNEWEKFRERIASLPMQAQWWKRIFLGNAMDVDMDATGRVLVSPELRQAAGISKDAVLLGMGSYFELWDAATYAAQEAEQMKGEMPDVFRDFSF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PITH1_SCHPO
Sequence: MSGPHHCSADCDEHPFESGPNDTLYSCIRKESIVTLNEAVPDSGKLVFKPWDLRYDDTDIVESDADDQLLFQVPFAGAATLKSILVRIFPNETAPHSFSLFPNRTDLDFDTIGDVQATETFEFPLTFEGSHIFEFPVKTRLYQNLQNLNIFFTKSDGSDDPTQIAYIGLRGSFVPFKGDPVVTIYEATPRPSDHPKVNQEEVFRSYY
What are the official names of this protein?
PITH domain-containing protein P35G2.02.
What is the protein family that this protein belongs to?
Belongs to the PITHD1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CYSG_SALAR
Sequence: MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLEAGARLTVNALTFIPQFTVWADEGMLTLVEGPFDEALLDPCWLAIAATDDDAVNQHVSEAAESRRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESILPQHLGQVAQYAGQLRARVKKQFITMGERRRFWEKFFVNDRLAQSLANADEKAVNATTEQLFSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGLPLTHRDYAQSVRLVTGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMQADMPVALVENGTSIKQRVVNGELAQLGELAKQVASPALIIVGRVVGLRDKLNWFSSH
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: NDKB_MOUSE
Sequence: MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIHLWFKPEELIDYKSCAHDWVYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).  Negatively regulates Rho activity by interacting with AKAP13/LBC.  Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically.  Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter.  Does not bind to duplex NHE III(1).  Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity.  Binds both folded and unfolded G4 with similar low nanomolar affinities.  Stabilizes folded G4s regardless of whether they are prefolded or not.  Exhibits histidine protein kinase activity (By similarity).
What are the official names of this protein?
Nucleoside diphosphate kinase B, NDK B, NDP kinase B, Histidine protein kinase NDKB, P18, nm23-M2.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Nucleus. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.
Protein: RL1_AFIC5
Sequence: MAVGKKLVKAREGIDREKLYAIADAIKLVKERATAKFDETIEVAINLGVDPRHADQMVRGVVTLPNGTGRTLRVGVFARGAKADEAKAAGADVVGAEDLVEIVQGGKIEFDRCIATPDMMPLVGRLGKVLGPRGMMPNPKIGTVTMDVAGAVKGAKGGSVEFRVEKAGIIQAGVGKASFSEEKLVENIKALADAVVKAKPAGAKGTYVQRVAVSSTMGPGVKVEPGSLNS
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: EFGM_CANAL
Sequence: MASVLRGVFKTHLPRTLTRPKCARTFQTTTFLRNEQVKLPQTYDEEKVIIDEINKSLKPDDLQASTRLRNIGISAHIDSGKTTFTERVLFYTGRIKAIHEVRGKDSVGAKMDHMDLEREKGITIQSAATYCSWDKDDKSYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVAGVQSQTVTVDRQMRRYNVPRVTFINKMDRMGANPWRAIEQINAKLKIPAAAIQVPIGAEENLQGVVNIIDRVALYNEGEQGETIRKAEVPEDLKELVEEKRALLIETLADVDEEMADIYLEGEEPTVEQIKGAIRRATIGRKFTPVLMGSALANRGIQPVLDSVVDYLPQPNEVLNTGLELQKDNSEKPVHLTPSTSEPFVGLAFKLEEGPYGQLTYIRVYQGKLKKGAYMTHVKTGKKVKVSRLVRMHSNDMEDVAEVGAGEICATFGIDCASGDTFIGQGTQQQITMSSMFVPEAVISLSISPKTKDNGAFSKAMNRFQKEDPTFRVHYDSESKETIISGMGELHLEIYVERIKREYGVDCVTGKPQVSYREAITVPSAFDYTHKKQSGGAGQYGRVIGEMNPIESENKFETQIIGGKIPEKFLFACSKGFEDCLEKGPLIGHRVLGVHMLINDGQTHVVDSSELAFRTATHGAFKQAFLNAQPVILEPIMSVEVTAPNEFQGSVVGLINKLGGMINDTVNGPDDFTVTAECSLNSMFGFSTSLRASTQGKGEFSLEFLKYSPTAPQVQKQLIQEYQKAQAAKK
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: APAH_PSEU2
Sequence: MAVYAVGDLQGCLEPLQCLLEHVHFNPEQDRLWLVGDLVNRGPQSLETLRYLYSLRESLVCVLGNHDLHLLAVARKKELLKKGDTLLEILEAPDRDDLLGWVRRQKLMHYDAQRNVAMVHAGIAPQWTLKKALKHAAEVEHALQDEQLYGAFLDGMYGNEPTRWDNDLQGVTRLRVITNYFTRMRFCTSDGKLDLKSKEGVGTAIPGYAPWFSHQSRKTRDVKIIFGHWAALEGRCDEPDVFALDSGCVWGGSMTLLNVDTLERHQCNCDAMGNAADGLVTRVQPGATPLP
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: MCH_METTR
Sequence: ICLGGLGKVTLAPAPGQTNWPFWLTVTSNDPVVACLASQYAGWSLSHEKFFALGSGPGRSLARKEPLFQELPYEDSASRATIVLEAGAPPPEPVVAKVAESCGVSPDKLAFIYAPTQSLAGSVQVVGRVLEVALHKAHELKFPLEHIVDGIATAPLSPPHPDFVTAMGRTNDAIIYSGRAHLFVRGSAEAAKALAEKLPSSNSRDYGRPFAEIFKAYKGEFYKIDPSLFSPAEAIVTAVETGETFRAGAIDEKLLDASFG
What is the function of this protein?
Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
What are the official names of this protein?
Methenyltetrahydromethanopterin cyclohydrolase, Methenyl-H4MPT cyclohydrolase.
What is the protein family that this protein belongs to?
Belongs to the MCH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YRAN_ECOLU
Sequence: MATVPTRSGSPRQLTTKQTGDAWEVQARRWLEGKGLRFIAANVNERGGEIDLIMREGRTTVFVEVRYRRSALYGGAAASVTRSKQHKLLQTARLWLARHNGSFDTVDCRFDVVAFTGNEVEWIKDAFNDHS
What are the official names of this protein?
UPF0102 protein YraN.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RL13_SHEAM
Sequence: MKTFTAKPETVSRDWYVVDAEGKTLGRIATEIASRLRGKHKPEYTPHVDTGDYIIVINAEKVTVTGNKAAGKMYYSHSGFPGGIKEINFEKLQAHKPEMIIEKAVKGMLPKGPLGRAMFRKLKVYAGAEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: LEPA_STRP4
Sequence: MNLEELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEIMPIINKIDLPAADPERVRTEIEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQVRVMDGVVKPGDKIQLMSNSKTFDVAEVGIFTPKAVGRDFLATGDVGYIAASIKTVQDTRVGDTVTLATNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMDVSNPSEFPDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFIVHKDFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKSIGSVEVPQEAFLSVLSMDEE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LANA1_LACLL
Sequence: MNKNEIETQPVTWLEEVSDQNFDEDVFGACSTNTFSLSDYWGNNGAWCTLTHECMAWCK
What is the function of this protein?
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria.  The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.  When present individually lacticin 3147 A1 exhibits strong activity towards L. lactis strain AM2, weak activity towards L. lactis strain HP and no activity towards L. lactis strain IFPL359, but when combined with lacticin 3147 A2 it displays strong activity towards all three strains.
What are the official names of this protein?
Lantibiotic lacticin 3147 A1.
What are the subcellular locations of this protein?
Secreted.
Protein: SAE1_MOUSE
Sequence: MVEKEEAGGGGGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPEDPGAQFLIQTGSVGRNRAEASLERAQNLNPMVDVKVDTEDVEKKPESFFTKFDAVCLTCCSRDVIIKVDQICHRNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPEAKRAKLDSSETTMVKKKVLFCPVKEALEVDWSGEKAKAALKRTAPDYFLLQVLLKFRTDKGRDPTSESYKEDAELLLQIRNDVFDSLGISPDLLPDDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGSGIVECLGPQ
What is the function of this protein?
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4.  It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).
What are the official names of this protein?
SUMO-activating enzyme subunit 1, Ubiquitin-like 1-activating enzyme E1A.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family.
What are the subcellular locations of this protein?
Nucleus.