PharMolix/UniProtQA huggingface dataset:
Protein: HIS4_AGRRK
Sequence: MILFPAIDLKDGQCVRLKLGDMNQATVYNPDPGAQAKAFEDQGFEWLHVVDLNGAFAGETVNGAAVDAILKATKNPVQLGGGIRTLDHIENWLARGLTRVILGTVAVRDPALVIEACKRFPGHVAVGIDAKGGKVAVEGWAEASELGIIELAKKFEGAGVAAIIYTDIDRDGILTGINWASTLELADAVSIPVIASGGLASMDDIRRMVEPDARKLEGAISGRALYDGRIDPQEALALIKAAKAKEIAQ
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YVBI_VACCC
Sequence: MRDVRPEYWMGLDVAVFLFFATSDVDRHLTVFDHSQSFFTSDRGRVLTLSWGHAGQSSIHCVSISGF
What are the official names of this protein?
Uncharacterized 7.6 kDa protein.
Protein: RS3A_MAGOY
Sequence: MAVGKNKRLSKGKKGLKKKTQDPFARKDWYGIKAPAPFNIRDVGKTLVNRSSGMKNANDALKGRIFEVSLADLQKDEDHAFRKIKLRVDEVQGKNCLTNFHGLDFTSDKLRSLVRKWQSLIEANVTVKTTDDYLLRLFAIAFTKRRPNQIKKTTYAASSQIRAIRRKMTEIIQREASTCTLQQLTNKLIPEVIGREIEKATQGIYPLQNVHIRKVKLLKQPKFDLGGLLALHGESTTDEQGQKVEREFKERVLEEV
What are the official names of this protein?
40S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_CHRVO
Sequence: MKSIKPVLLLILDGFGHRTEGDDNAILHARMPVWSRLREQYAYGTINASENFVGLPSGQFGNSEVGHLNIGAGRIVQQDISRIDCDIEDGRFSSNDTLQQAMSKAQGSALHILGLLSDGGVHSHENHIHALIRAAQAAGVPKIYVHAFLDGRDTPPRSAETYLKRLDAALAECPNARLVSVTGRYWAMDRDKRWERVEPAYRLLVDGEGLFHAETGLDALKAAYERDENDEFVKATGIGAPVKMQDGDALIFMNFRADRARQLTSALTDPAFDGFKARQPKFGYYATLTSYGEAYSALPVAYAPQKIHNGMGEYLSSKGLKQLRIAETEKYPHVTYFFNGGEEQVYPGEDRILVPSPKVATYDLQPEMSAGEVTDKIVAAIQSGQYQAIFCNYANGDMVGHSGVFDAAVKAVEALDGCIERCVDAMLAAGGEVLITADHGNCEQMYDGEHHQPHTQHTTNQVPFLYIGRPAKIRAGGSLRDISPSLLAMMGLEQPAEMTGQSLIDFQ
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: COXX_THET2
Sequence: MKTPAWSRLAGYAWGVLLWNVLVALFGAYVRATGSGAGCGAHWPTCNGEVIPRAPQVETLIEFTHRATSGLAFLSVLALFLWALRAFPKGHPARFGAGLALFFMVTESLVGASLVLFGWTADNVSRERAVVQMVHLANTYFLLAALALTAWWASGGGPLRLRGQGAVGLALFLGLLALLFLGMSGAVTALGDLLFPVGSTLEALERSLTPGEHFLVRLRVLHPLIAVSVGLYVVFAGYLVAHLRPSPLTRRLAQGLAYLYGAQLLAGLINVALKAPVWMQILHLLLAYAVWLLFVFLATSALERGAKRVELGEGGEAVHRGTGGATWRDYLALTKPRVISLLLFTALFGALIAAKGWPGLGVFLAVALGGYMMAGAANAINMVVDRDIDARMKRTAKRPTVTQRVSSRDALLFAFALAVLGFAVLWWGANLLAATLALMGLIWYVLVYTLYLKRRTWHNIVIGGAAGAFPPLVGWAAVTGELSLFAWYLFALIFFWTPVHFWALALMIQDDYRAVGVPMLPVVLGERATVIQIALYALLTALISLMPLLLGELGLLYLAASLLLNALLLLKSLALYRRPERRTAVSLYKYSMLYLALLFAAMAVDRAV
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SULA_ECOK1
Sequence: MYTAGYAHRDSSFSSTASKIARVSTENTTAGLISEVVYREDQPMMTQLLLLPLLQQLGQQSRWQLWLTPQQKLSREWVQASGLPLTKVMQISQLSPCHTVESMVRALRTGNYSVVIGWLADDLTEEEHAELVDAANEGNAMGFIMRPVSASSHATRQLSGLKIHSNLYH
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: RL7_ASHGO
Sequence: MADKILTPESQLKKSKAQQKSAEQVAAERAARKAANKEKRAAILERNAAYHKEYETAERAVIQAKREAKANGSYYVESQPKLVFVIRIKGINKIAPKPRKVLQLLRLNQINSGVFVKVTKATTELLRLVEPYVAYGYPSYSTIRQLVYKRGYGKINKQRIALSENSIVEANLGKYGIISVDDLIHEIITVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKHFIQGGAFGNREEFINKLVKSMN
What are the official names of this protein?
60S ribosomal protein L7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: CD3E_CHICK
Sequence: MRCEVPLPLLGLLLCVVGAAAQGGQEEFAVEISGTTVTITCPSSGDDVKWKPDPKMVVNNKYIIQNHDSSPLTVSCTAGDEEHTMYLNAKVCANCEELDTFTVVGIIAADLLITLGVLILVYYFSKNKKGQSRAAAGSRPRAQKMRRPPPVPNPDYEPIRKGQRDVYAGLEHRGF
What is the function of this protein?
The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation.  Required for normal immune responses.
What are the official names of this protein?
T-cell surface glycoprotein CD3 epsilon chain.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RL15_TREDE
Sequence: MFEFNLTVPAGATHKKKIVGRGSSSGWGKTSGKGHKGQQARSGGKVYAGFEGGQMPLYRRVAKKGFSNYPFKKEFYVVNLAMLETKYSDGETVNKESLMQKGLLRKGSLYVKVLGTGDITKKLTVDVDRISASAKEKIEKAGGTIVQSEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RLMD_SALTI
Sequence: MAQFYSAKRRVTTRQIITVKVNDLDSFGQGVARHNGKALFIPGLLPEESAEVIITEDKKQFARARVSRRLNDSPERETPRCPHFGVCGGCQQQHVGIDLQQRSKSAALARLMKHEVNDIIAGASWGYRRRARLSLNCPPDKPLQMGFRKAGSSDIVNVEQCPVLAPQLEALLPRIRACLASLHGTRHLGHVELVQAGSGTLMILRHTAPLSAADKEKLERFSHSEGLSLFLAPFSEILETVSGEAPWYDSHGLRLTFSPRDFIQVNEAVNQQMVARALEWLDVRAEDRVLDLFCGMGNFTLPLATRAASVVGVEGVQALVEKGRENAIRNGLHNVTFFHENLEEDVTKQPWAKNGFDKVLLDPARAGATGVMRHIIKLKPIRIVYVSCNPATLARDSEALVNAGYEVTRLAMLDMFPHTGHLESMVLFERM
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: SYS_HAEIG
Sequence: MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIGAAKARGEDIAPLLAEMDDMGNQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTENKEILRWGTPRTFDFEVKDHVTLGEEANGLDFAAGAKLTGARFAVMKGQIAKMHRALAQFMLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALQGEQPYALIPTAEVPVTNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSMEALEELTGHAEKVLQLLNLPYRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARCKAKGDKKTHLVHTLNGSGLAVGRTLVAVLENYQNADGSITVPEVLRPYMGGLDVIGK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL12B_PAPAN
Sequence: MCHQQLVISWFSLVFLASPLMAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSGEVLGSGKTLTIQVKEFGDAGQYTCHKGGEALSHSLLLLHKKEDGIWSTDVLKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSNPQGVTCGAVTLSAERVRGDNKEYEYSVECQEDSACPAAEERLPIEVMVDAIHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQAEVSWEYPDTWSTPHSYFSLTFCIQVQGKSKREKKDRIFTDKTSATVICRKNASFSVQAQDRYYSSSWSEWASVPCS
What is the function of this protein?
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.  IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.  IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines.  IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
What are the official names of this protein?
Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40.
What is the protein family that this protein belongs to?
Belongs to the IL-12B family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL27_BACCZ
Sequence: MLRLDLQFFASKKGVGSTKNGRDSQSKRLGAKRADGQTVSGGSILYRQRGTKIYPGVNVGRGGDDTLYAKVDGVVRFERLGRDRKQVSVYPVAQEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: ZIPA_MANSM
Sequence: MDLNTILIILGILALVALVAHGLWSNRREKSQYFENANTFGRANRQDEPISTPESYKQARNVAPAFTQPKQAVIHQEPPVQQPLNTEPEPITQETPVRAEPQSVDQIKITLPNVEPAPAESAPIYEMRPSRRNTEPQYYQQPSEPYYQQPVQQNLARQTIADIEATVDPNEGVNSSSEYLRTQLQEASQEGNQIFTQSPLSRAPLQQPIEFDQPAQQEKESDNNEDEDVSFVMLYVAAAENRQFQGTVLVQALEDLGFSLGEDNLYHRHLDLTVASPVLFSAANITQPGTFNPYTLHEFFTDGVAIFMRLPSPGNDRTNLKIMIRSAKTLAQQLGGFVLTEQQELFTDAAEEEYLAKIK
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: RS12_METHJ
Sequence: MGQGKFAARKLKRDSARFRWSDPHFARTAGGLKLKSDPLEGAPQGRGIVLEKIGVEAKQPNSAIRKCVRVQLIKNGRQVSAFAVGDGAINFIDEHDEVEIEGIGGRLGRSMGDIPGVRFVVTKVNNVCLHELVIGRKEKPRR
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: NVFF_ASPN1
Sequence: MTVSTPSKPHICRFPPGADPDVINQAFREDGVVILEGFLTPAQVDKVNCEMKPHLAKVRGGNMRYGPMDTSLETTLEPERRRIHNLAGLSETFRQDILNHPLMHELSRRVFSEFGDYWQYAGSVIDCAPGTPDQFLHRDQPAQKLFNVGPDAPEGFINFLTALTDFTKTNGATRFVWGSHRDWIDKSDENHPIVVAEVKAGDSLFFSGKIVHGGSFNGTNDTYRSSVALPIVPCIMTPYEANIHIPRSTVETMTPLAQRMIGWRSACLPDPYAIGTWTLNMNELGEQMGLKSKGYLEN
What is the function of this protein?
Fe(II)/2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety (PubMed:29968715).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase nvfA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (PubMed:29968715).  DMOA is then converted to farnesyl-DMOA by the farnesyltransferase nvfB (PubMed:29968715).  Epoxydation by FAD-dependent monooxygenase nvfK, followed by a protonation-initiated cyclization catalyzed by the terpene cyclase nvfL leads to the production of asnavolin H (PubMed:29968715).  The short chain dehydrogenase nvfC then as a 3-OH dehydrogenase of asnovolin H to yield chemesin D (PubMed:29968715).  There are two branches to synthesize asnovolin A from chemesin D (PubMed:29968715).  In one branch, chemesin D undergoes Baeyer-Villiger oxidation by nvfH, methylation by nvfJ, and enoyl reduction by the nvfM D enoylreductase that reduces the double bond between C-5'and C-6', to form respectively asnovolin I, asnovolin K, and asnovolin A (PubMed:29968715).  In the other branch, the methylation precedes the Baeyer-Villiger oxidation and the enoyl reduction to yield asnovolin A via the asnovolin J intermediate (PubMed:29968715).  Asnovolin A is further converted to fumigatonoid A by the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfI that catalyzes an endoperoxidation reaction (PubMed:29968715).  The alpha/beta hydrolase nvfD then acts as an epimerase that converts fumigatonoid A to its C-5' epimer, which then undergoes spontaneous or nvfD-catalyzed lactonization (PubMed:29968715).  The following step utilizes the ketoreductase nvfG to produce fumigatonoid B (PubMed:29968715).  The dioxygenase nvfE further converts fumigatonoid B into fumigatonoid C (PubMed:29968715).  Finally the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfF catalyzes two rounds of oxidation to transform fumigatonoid C into the end product, novofumigatonin A (PubMed:29968715).
What are the official names of this protein?
Fe(II)/2-oxoglutarate-dependent dioxygenase nvfF, Novofumigatoninbiosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: ATPB_MYCGA
Sequence: MNTKYSYGKVYQVVGPVVDVVFEKQDDLPKIYDCLIIDEPNMKLHLEVAQLIGDDIARCIAMGPTEGLARNVKVTSTNQPISVPVGTEVLGRMFNVIGEPIDEKKPIDASVKRMSIHRPAPSFADQSNELEIFETGIKVIDLLIPYAKGGKIGLFGGAGVGKTVLVQELIHNIATGHGGLSVFAGVGERTREGNDLYYEMIEGGVIDKTALVFGQMNEPPGARMRVALTGLTMAEYFRDVNNQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLAEEMGSLQERITSTKSGSITSVQAIYVPADDLTDPAPSTTFTHLDAKTVLDRNIASLGIFPAVNPLDSTSRLLDPSVVGIQHYQTARKVQMILQKFLELQDIIAILGIDELSEEDKLTVSRARKIRNFLSQPFFVAEKFSGNKGKYVPISETIKGFSEIVEGKHDDLPEQAFFYVGSIDEAIERAKTLTRNG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HUGAA_VESVU
Sequence: SERPKRVFNIYWNVPTFMCHQYDLYFDEVTNFNIKRNSKDDFQGDKIAIFYDPGEFPALLSLKDGKYKKRNGGVPQEGNITIHLQKFIENLDKIYPNRNFSGIGVIDFERWRPIFRQNWGNMKIHKNFSIDLVRNEHPTWNKKMIELEASKRFEKYARFFMEETLKLAKKTRKQADWGYYGYPYCFNMSPNNLVPECDVTAMHENDKMSWLFNNQNVLLPSVYVRQELTPDQRIGLVQGRVKEAVRISNNLKHSPKVLSYWWYVYQDETNTFLTETDVKKTFQEIVINGGDGIIIWGSSSDVNSLSKCKRLQDYLLTVLGPIAINVTEAVN
What is the function of this protein?
Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.
What are the official names of this protein?
Hyaluronidase A, Hya A, Allergen Ves v II, Hyaluronoglucosaminidase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 56 family.
What are the subcellular locations of this protein?
Secreted.
Protein: G3P_METMP
Sequence: MANVLINGYGSIGKRVADAVAKQDDMKVIGVTKTKPDFEAKMAVEKGYKLFAAIPERKHLFEEAGIPVEGTLDDIIEDADIVVDGAPKKIGKANLENVYKKHGVKAIIQGGEKAGDAQDSFNSLWSYDRCYGKDYIRLVSCNTTGLCRSMYAINSVADILKARIVLIRRAADPNDIKTGPVNAIVPNPVTVPSHHGPDVVSVIPELDGKIMTSAVIVPTTLMHMHSIMVETSGTNRDEIIDALAKTPRILTVKASEGFDSTAKIIEYARDLGRSRYDLNEIAVWEESVNVVDNEVYMMQAIHQESDVIPENVDCIRAMLEMESDNLKSIEKTNKALGLIK
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_STRSV
Sequence: MAKPTRKRRVKKNIESGIAHIHATFNNTIVMITDVHGNAIAWSSAGALGFKGSRKSTPFAAQMASEAAAKSAQEHGLKSVEVTVKGPGSGRESAIRALAAAGLEVTAIRDVTPVPHNGARPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: DTB1A_DANRE
Sequence: MFENFREKLQTVQQDFTSGIKTLSDKSKEAKVKKKQRRDEYLPQYSAGVELLSRYEDTWVALHKRAKESAKSGETVDGEVVMLCAHWEKRRGAVLELQEQLQQIPTFLSDLETITSRIAHLEADFEEMESRLVYLEDLCAQCEHQRFKQFQILQLENYKKKKRKELESCKAELDAEHAQKVLEMEHAQQVKLKERRKYFEEAFQQDMEQYLSTGYLQITDRRDPLGSMSSMEVNVDLLEQMDLTDVSDHEALDVFLSSVGEESSAVSPDAGGPSLEPGSSPSDISLKVPSQSELRHNISSISSSCTDTVSGTTEGPDEEESSSGDSPLVQSDEEEVHADTALMGLPETEALKSSDDSDTQAP
What is the function of this protein?
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes.  Plays a role in intracellular vesicle trafficking.  Plays a role in synaptic vesicle trafficking and in neurotransmitter release.  May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus.  Plays a role in the regulation of cell surface exposure of DRD2.  Contributes to the regulation of dopamine signaling.  May play a role in actin cytoskeleton reorganization and neurite outgrowth (By similarity).
What are the official names of this protein?
Dysbindin-A, Biogenesis of lysosome-related organelles complex 1 subunit 8-A, BLOC-1 subunit 8-A, Dystrobrevin-binding protein 1-A.
What is the protein family that this protein belongs to?
Belongs to the dysbindin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Postsynaptic density. Endoplasmic reticulum.
Protein: AROE_SPHAL
Sequence: MSHPYASPFAEVIGDPIAQSKSPLIHGFWLDALGMEGDYRRAHVKADALAAYIAERRADPGWRGCNVTMPHKAAVMDLVDDPGDIRGTIGAMNTIVRQPDGSLIGTNTDAAGFYSPLAELDLEGAPIAVVGAGGAARAVLFALARAKVGKVAILNRSPLKAMGLLATFGLKGDVVALDAALPPVRLLVNASSLGMAGQPPLDLDLSPLPDDAIVYDLVYSPLRTGLLKAAEARGLDTVDGLDMLIGQAALAFELFFGAPPPEGRDDELRALLVA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: BIOB_YERPN
Sequence: MATYHHWTVGQALALFDKPLLELLFEAQQVHRQHFDPRQVQVSTLLSIKTGACPEDCKYCPQSSRYKTGLESERLMQVEQVLESAKKAKAAGSTRFCMGAAWKNPHERDMPYLAKMVEGVKALGMETCMTLGSLSKQQAHRLADAGLDYYNHNLDTSPEFYGSIITTRSYQERLDTLNEVRDAGIKVCSGGIVGLGETVRDRAGLLVQLANLPKPPESVPINMLVKVKGTPLENNAEVDAFEFIRTIAVARIMMPSSYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPDEDKDLQLFRKLGLNPQQTATSHGDREQQQALTEQLLHGDTAQFYNAAV
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: MSHD_CLAMS
Sequence: MSAFPPPPEPDAPRVAHVEPAPDAVRGILALADRARADDGVAPFNEQTRLTLGADGGPTLLLAHGTDDDPLGAAVVAHGDAGIEAELVVDPAHRRRGVGRALLDAVLAEAAGSPVSVWAHGDHPAARALADATGLDRARELLQLRASVAEARTGLGERQMPAGVALSSFTADDADDWVALNARAFASHPEQGRMTRGDLDDRVAEAWFDPASLLLARDADGRLAGFHWLKVDGGQAEVYVLGVDPDRAARGLGSALLAAGLDLLAERGHDEVDLYVEADNTPALALYRRAAFRDAAVDVQYRRA
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: RS11_SYNS9
Sequence: MAKTAKKSGPKKAKRNVPNGVAHIQSTFNNTIVSISDTAGEIIAWSSAGASGFKGARKGTPFAAQTAAEAAARRALEQGMRQIEVLVRGPGSGRETAIRALQVAGLEITLIRDVTPLPHNGCRRPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: ARLY_CUPMC
Sequence: MTSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAEIERGMTQIRGEIESGAFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQVATDIRLWLRSEIDSIVGLLGDLRGALLDLAEKNADTILPGFTHLQVAQPVTFGHHLMAYVEMFTRDAERMADCRRRVNRLPLGAAALAGTSYPIDREFVATQLGFDGVCRNSLDAVSDRDFAIEFLAAASLIMTHVSRFSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVYGHLTGLLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGISVKPDNMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVRACDDRHCDLADLTVEQLREVSGLGDKASLIGDDVHSVLTLEGSVASRNHIGGTAPDQVRAAIAAARKAL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPRF_STAAN
Sequence: MNQEVKNKIFSILKITFATALFIFVAITLYRELSGINFKDTLVEFSKINRMSLVLLFIGGGASLVILSMYDVILSRALKMDISLGKVLRVSYIINALNAIVGFGGFIGAGVRAMVYKNYTHDKKKLVHFISLILISMLTGLSLLSLLIVFHVFDASLILDKITWVRWVLYVVSFFLPLFIIYSMVRPPDKNNRFVGLYCTLVSCVEWLAAAVVLYFCGVIVDAHVSFMSFIAIFIIAALSGLVSFIPGGFGAFDLVVLLGFKTLGVPEEKVLLMLLLYRFAYYFVPVIIALILSSFEFGTSAKKYIEGSKYFIPAKDVTSFLMSYQKDIIAKIPSLSLAILVFFTSMIFFVNNLTIVYDALYDGNHLTYYILLAIHTSACLLLLLNVVGIYKQSRRAIIFAMISILLITVATFFTYASYILITWLAIIFVLLIVAFRRARRLKRPVRMRNIVAMLLFSLFILYVNHIFIAGTLYALDIYTIEMHTSVLRYYFWLTILIIAIIIGMIAWLFDYQFSKVRISSKIEDCEEIINQYGGNYLSHLIYSGDKQFFTNENKTAFLMYRYKASSLVVLGDPLGDENAFDELLEAFYNYAEYLGYDVIFYQVTDQHMPLYHNFGNQFFKLGEEAIIDLTQFSTSGKKRRGFRATLNKFDELNISFEIIEPPFSTEFINELQHVSDLWLDNRQEMHFSVGQFNEEYLSKAPIGVMRNEENEVIAFCSLMPTYFNDAISVDLIRWLPELDLPLMDGLYLHMLLWSKEQGYTKFNMGMATLSNVGQLHYSYLRERLAGRVFEHFNGLYRFQGLRRYKSKYNPNWEPRFLVYRKDNSLWESLSKVMRVIRHK
What is the function of this protein?
Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge.  LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins).  In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides (By similarity).
What are the official names of this protein?
Phosphatidylglycerol lysyltransferase, Lysylphosphatidylglycerol synthase, LPG synthase, Multiple peptide resistance factor.
What is the protein family that this protein belongs to?
Belongs to the LPG synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSMD9_SCHPO
Sequence: MDEFKQLDLKKREIENRLNELEGVLLKERVTMDTPLLTEDGFPRSDIDVPSIRTARHEIITLRNDHRELEDQIKKVLEKVFSGFSKESLAANDETKLAQEADPLNFNAANYNMNDIISRSKILGRVKPFCVVDSVAVESPAQEAGLCIGDELVHVQNVTSLSELPTFISNNVNKTLDVLLIRGYSADGSTNLVELKLTPHKWQGPGLLGCHLR
What is the function of this protein?
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).
What are the official names of this protein?
Probable 26S proteasome regulatory subunit p27.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.