PharMolix/UniProtQA huggingface dataset:
Protein: ZP2_MACRA
Sequence: MACGQRGGSWRPSGWFNAGWSTYRSISLFFALVTSVNSIDVFQLVNPAFPGTVICDERGITVEFPSSPGTKKWHASVVDPLGLNVPNCTYILNPEKFTLRVTYENCTRRVHGGYQMTIRVMNDSAALRHGAVMYQFFCPAMQVEETQGLSASTICKKDFMSFSLPRVFSGLADDNKVTKLKMGWSIEVGDGARVKTLTLPEAMKEGFSLLIDNHRMIFHVPFNATGVTHYVQGNSHLYMVSLKLTFISPGQKVIFSSQAICAPDPVNCNATHMTLTIPEFPGKLKSVSFENQNIDVSQLHDNGIDLEATNGTKLHFSKTLLKTKLSEKCLLHQFYLASLRLTFLLQSETVSMVIYPECVCESPVSIVTGELCTQDGFMDFEVYSYQTQPALDLDTLRVGNSSCQPVFKAQSQGLVRFHIPLNGCGTRYKFEDDKVIYENEIHALWTDLPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLGPFTLILQSYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVINRDDPNIKLVLDDCWATSTMDPDSFPQWNIVVDGCAYELDNYQTTFHPVGSSVTHPDHYQRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATEATEAEKMTVSLPGPILLLSDDSSFRGVGSSDLKASGSSGENSRSETGEEVGSRDVMDTKGHRTAGDVGSKAVAAVAALAGVVATLGFICYLYKKRTVSNH
What is the function of this protein?
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy.  The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4.  ZP2 may act as a secondary sperm receptor.
What are the official names of this protein?
Zona pellucida sperm-binding protein 2, Zona pellucida glycoprotein 2, Zp-2, Zona pellucida protein A.
What is the protein family that this protein belongs to?
Belongs to the ZP domain family. ZPA subfamily.
What are the subcellular locations of this protein?
[Processed zona pellucida sperm-binding protein 2]: Zona pellucida. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Protein: URE1_HAEIG
Sequence: MALTISRAQYVATYGPTVGDKVRLGDTNLWATIEQDLLTKGDECKFGGGKSVRDGMAQSGTATRDNPNVLDFVITNVMIIDARLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIGASTEVHNGVHLIATAGGIDTHIHFICPQQAQHAIESGVTTLIGGGTGPADGTHATTCTPGAWYMEHMFQAAEALPVNVGFFGKGNCSTLDPLREQIEAGALGLKIHEDWGATPAVIDSALKVADEMDIQVAIHTDTLNESGFLEDTMKAIDGRVIHTFHTEGAGGGHAPDIIKAAMYSNVLPASTNPTRPFTKNTIDEHLDMLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGVFSIMSSDSQAMGRIGEVVIRTWQTADKMKMQRGELGNEGNDNFRIKRYIAKYTINPAIAHGIAEHIGSLEVGKIADIVLWKPMFFGVKPEVVIKKGFISYAKMGDPNASIPTPQPVFYRPMYGAQGLATAQTAVFFVSQAAEKADIRAKFGLHKETIAVKGCRNVGKKDLVHNDVTPNITVDAERYEVRVDGELITCEPVDSVPLGQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_MYCCT
Sequence: MFAIIKTGGKQVKVEPGQEIFIEKIKGEVNDKIAFDEILMIDGQIGTPTIEGAKVLGTIVKQGKAKKIRVIRYHPKKNVNKIYGHRQPYTKVKIEEISAK
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: ISPH_PSEAE
Sequence: MQIKLANPRGFCAGVDRAIEIVNRALDVFGPPIYVRHEVVHNKFVVDNLRQRGAIFVEELDQVPNNVIVIFSAHGVSQAVRKEAEGRGLKVFDATCPLVTKVHMEVVRYSRDGHECVLIGHEGHPEVEGTMGQYDASNGGAIYLVEDEADVAALEVRKPEALHYVTQTTLSMDDTSKVIDALRAKFPQIQGPRKNDICYATQNRQDAVKELADQCDMVLVVGSPNSSNSNRLRELAERMGTPAYLIDGAEDMQRGWFDGVRRIGITAGASAPEVLVRGVIAQLREWGASEEQELEGREENITFSMPKELRVKAL
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: GATB_RICAE
Sequence: MAYIEGNTGKWEYVIGLEIHAQISSKSKLFSGSSTIFAANPNSQVSYVDAAMPGMLPVLNKHCVHQAIKTGLGLKAKINKYSVFDRKNYFYADLPQGYQISQFYYPIVQNGTMEIPTSTGDLKTIRINRLHLEQDAGKSMHDQSPHYSFIDLNRAGIGLMEIVTEPDISSPEEAAEFVKKLRNLLRYIGSCDGDMEKGSMRCDANISVRRSGEPLGTRCEIKNINSIRNIIKAIEFEAKRQVDLLESGEEIIQETRLFNADSGETRTMRLKEEALDYRYFPDPDLLPLVISDELINELKANLPELPDQKIEKYTKEFSLSKYDAEVIVADESVAEYFEKAANECNPKMLTNWLTSELFGQLNKASIGINECKITPSNFAKLVKLIENDTISGKIAKTVFEIMFETGKAPDKIVEEKGLVQVSDNNVLNTVIDEVIAENPESVEGYRSGKDKLFGFFVGQVMKKTGGKANPTLVNQLLKEKLSS
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: SLYX_PSEAE
Sequence: MELDARMDDLECRQAFQDDTLQALNDVVVEQQRSIERLQLQVAALIKRLEDVQGLVGEAGEDEAPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: DC2L1_HUMAN
Sequence: MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWKQIELDS
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles (PubMed:29742051).  Involved in the regulation of ciliary length (PubMed:26077881, PubMed:26130459).
What are the official names of this protein?
Cytoplasmic dynein 2 light intermediate chain 1, Dynein 2 light intermediate chain.
What is the protein family that this protein belongs to?
Belongs to the dynein light intermediate chain family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the apical cytoplasm.
Protein: PEBP4_MOUSE
Sequence: MTMKLVAAALCLSLLAAGLWVGLSLTAESIEEGKPGGEKPGGGKPGGSGRGCFLPPLPKEDVSLCRNLEVFYMEMGNISCKIVPKCNLYRQKITAWQAPIVKFHTALDGALYLLVMVDPDAPSRSNPVMKYWRHWLVSNITGADMKSGSIRGNVLSDYSPPTPPPETGLHRYQFFVYLQGDRDISLSVEEKADLGGWNLDKFLQQYGLRDPDTSTQFMTQFDEELSSEFGRINDDQEQFNQK
What is the function of this protein?
Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.
What are the official names of this protein?
Phosphatidylethanolamine-binding protein 4, PEBP-4.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylethanolamine-binding protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y033_BAUCH
Sequence: MNKIIEKMIYESRWLLFPVYIGLSFGFILLTLKFFHEIIQFLPKIFDMPESDLILIVLSMIDIALVGGLLVMVMFSGYENFILKMSDDCNQKRLNWMGKMDVNSIKNKVASSIVAISSVHLLRIFMEADRTRDNKIMWCVIIHLAFVLSAFGMAYIDKMSKTKS
What are the official names of this protein?
UPF0114 protein BCI_0033.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLP7_CAEEL
Sequence: MLGSRFLLLALGLLVLVLAEESAEQQVQEPTELEKSGEQLSEEDLIDEQKRTPMQRSSMVRFGRSPMQRSSMVRFGKRSPMQRSSMVRFGKRSPMQRSSMVRFGKRSPMERSAMVRFGRSPMDRSKMVRFGRSSIDRASMVRLGKRTPMQRSSMVRFGKRSMEFEMQSNEKNIEDSE
What is the function of this protein?
Acts as a ligand for the npr-22 receptor in vitro.
What are the official names of this protein?
FMRFamide-like neuropeptides 7.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted from the ASI sensory neurons in response to serotonin or octopamine.
Protein: Y592_PELUB
Sequence: MSGHSKWASIKHSKGKADKQRSKVFSKLSKEISVAAKLGDKDPAMNPRLRSAIQAAKSANMPKDNIERAIAKSSVNSETNYENLRYEGFGPDKIAVIVEALTDNKNRTASNVRSIFVKSGGNLGTQGSASHNFNQLGIIKIDKKEISDEQIFELAIESGADECISNDEFHEIQCPMSEIYNVKKNLEKTIANFISTEIEWVPLNSVDVEKDKVEAALEFLETLEDDDDVQSVYSNINFKNN
What are the official names of this protein?
Probable transcriptional regulatory protein SAR11_0592.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWI6_KLULA
Sequence: MSRPIFKVHKGDRITFQQRLQDGYVCLDQFIPLLTNLSSFNFHRDDPLVENLDDMVTSQFNILIDTDRSGTRWITLQKAHELWDLLQIKDDSGSENLTDHDDDNEANHNGVEDDGQKTPENNGRKTDNHTMENGGTENTNNGNNSSNKNDGNVTAEGSNFRPATITNGTTSRISGGEPDTVKHELLDLPDSPTKRHQTKSVSKIPVFQHDLPTVSTLQKTLPPVSNYSNDERAKLETLLQRILFPETTNLNVAEGYPSVSLTQQVQELDTQFPNVPLNFNIPIDEHGNTSLHWLCSIANLDLLKQLIVFGSDRRIGDKSGESVLVKSVKSVNNYDSGTFEILLDYLYPCIVMVDDMDRTVLHHIVITSGMPGCNAAAKYYLDILMGWIVKKQSRTKESHCVLLEDIDLQWVITHLLNARDSNGDTCLNIAARLGNVAIVEALLDYGADPNIANNSGLCPVDFGAGTQPRFQSNTKNLMATPTKTHETSLDPMAESTSLITNIKSLLSKISNDYGDEIKQHNGKMKELLDTLNIKREALANARDRLAKAKQIQDEYNLLSDRLNNVENTIAEEDQNFQLASRELGLSLDDVQEEGLNSADIAFDADEPFRISYVYTKFEEKIKDEYNNDFELFLKHCNLSQLVHEIYDNFPSRAEIPHPKILKARIKAYNRNELHLDSTLQTIIPHPKILKARIKAYNRNELHLDSTLQTIKDKQKNLESKFRKVLSLCLKIDEEKVDSMLDGLLQAISNEDPEDIDTDEVNNFLESAAE
What is the function of this protein?
Part of a complex involved in cell-cycle-dependent transcription.  SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex.  The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).
What are the official names of this protein?
Regulatory protein SWI6, Cell-cycle box factor subunit SWI6, MBF subunit P90, Trans-acting activator of HO endonuclease gene.
Protein: YCF2_CERDE
Sequence: MKRYPFKSWIFELREILREIKNSHYFLDSWTRFDSVGSFTHIFFHQERFMKLFDPRIWSILLSRDSQGSTSNRYFTIKGVVLLVVAVLIYRINNRTMVERKNISLMGLLPIPMNFIGLRNDTLEEAFWSSNINRLIASLLYLPKRKKISESCFMDPKESTWVLPITKKRIMPESNWGSRWWRNRIGKKRDSSCKISNETVAGIEISFKEKDIKYLEFLFVSYTDDPIRKDHDWELFDRLSPRKKRNIINLNSGQLFEILVKHSICYLMSVFREKRPIEVKGFFKQQGAEATIQSNDIEHVSHLFSRDQWGISLQNCAQFHMWQFRQDLFVSWGKNPHESDFLRNASRENWIWLDNVWLVNKDRFFSKVRNVSSNMEYDSTRSLFVQVPDSSQWKGSSDQSRDHFDSISNEDSEYHTWINQTEIQQLKERSILWDPSFLQTERTEIESDRFPKCLSGYSSMYRLFTEREKQMNNHLLPEEIEEFLGNPTRSIRSFFSDRWSELHLGSNPTERSTRDQKSLKKQQDVSFVPPRRSENQEMVDIFKIITYLQNIVSIHPISSDPGCDMVPKDEPDMDRSNKISFLNKNPFFDLFHPFHDRNKGGYTLHHDFESESEERFQEIADLFTLSITEPDLVYHKGFAFSIDSYGLDQTKFLNEVFNSRDESKKKSLLVLPPIFDEENESFSRRIRKKSGRISCGNDLEDPKQKIVVFASKNIMEAVNQYRLIRNLIQIQYSTYGYIRNVLNRFFLMNGSDRNFEYGIQRDQIGTDTLNHITIMKYTINQHLSNLKKSQKKWFNPLISRTERSMNRDPNAYRYKWFNGSKNFQEHLEHFVSEQKNRFQVVIDRLRINQYSIDWSEVIDKQDLSKSLRFFLSKSLLFLSKSLLFLSKSLPFFFVSIGNIPIHRSEIHIYELKGPNDQLCNQLLESIGVQIVHLNKLKPFLLDDHDTSQRSKFLINGGTISPFLFNKIPKWMIDSSHTRKNRRKSFDNTDSYFSMISPDRDNWLNPVKPFHRSSLISSFYKAIRFLNNPHPFWFYCNKRFPLYVDVEKARINNYDLTYGQFLNILFIRNKIFSLCVGKKKHVFLERDTISPTESQVSDIFIPNDFPQSGDETYNLYKSFHLPIRSDPFVRRAIYSIADIYGTPLIEEQIVNFERTYCQPLSDMNISDSEGKNLHHQYLSFNSNMGLIHTPCSEKDFPSGRRKKKSIYLKKCVEKWRMYRTFQRDSAFSNLSKWNLFQTYMPWFLTSTGCKYLNFTLLDTFSDPLPILSSSPKFVSIFHDIMHGSDISWPIRQKKWWAILPQRNLISEISSKCLQNLLLSEEMIHRNNESPVPLIWTHLRSPNAREFLYSILFLLLVAGYLVRTHLLFVSRASSELQTELEKIKSLMIPSYMIDLRKLLDRYPTSELNSFWLKNLFLVALEQLGDSLEEIRGYANTLLGGGPAYGEKSIRSKKKYWNINLIDLISIIPNPINRITFSRDTRHLSRTSKEIYSLIRKRKNVNGDWIDDKIESWVANSDSIDDEEREFLVQFCTLATEKRIDQILLSLTHSDHLSKNDSGYQMIEQPGSIYLRYLVDIHQKYLMNYEFNRSCLAERRIFLAHYQTITYSQTSCRANSSHFPSHGKPFSLRLALSPSRGILVIGSIGTGRSYLVKYLATNSYLPFITVFPNKFLDDKPKGYLSDDIDIDDSDAIDDSDDIDDSDDIDDDLDTELLTMYMTPKIDRFDITPQFELAKAMSPCIIWIPNIHDLYVNESNYLSLGLLVNYLSRDCERCSTRKILVIASTHIPQKVDPALIAPNKLNTCIKIRRLLIPQQRKRFFILSYTRGFRLEKKMFHTNGFGSITMGSNARDLVALTNEALSISITQKKSIIDTNTIRAALHRQTWDLRSRVRSVQDHGIFFYQIGRAVAQNVLLSHCPIDPISIYMKKKLCKEGDSYLYKWYFELGTSIKKFTILLYLLSSSAGFVAQDLWSPPGPDEKNGITSYGFVENDSDLVHALLEVEGALVGSSRTEKDCSQFDNDRATLLLRSEPRNQLDMMQNGSCSIVDQRFLYEKDESDFEEGEGALDPQQIEEDLFNHIVWAPRIWRPCGNLFDCIESPNSLGFPYWARSSRGKRIIYHKEDEHQENDSEFLQSGTMQYQTRDRSSKEQGFFRISQFILDPADPFFFLFKDQPFVSVFSRREFFADQEMSKGLITSQTNPPTSLYKRWFIKNTQEKHFQLLIHRQRWLRTNSSLSNRSSRSNTPSESYQYLSNLFLSNGTLLDQMTKTLLRKRWLFPDEMKHLIHVTGERFPIP
What is the function of this protein?
Probable ATPase of unknown function.  Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis.
What are the official names of this protein?
Protein Ycf2.
What is the protein family that this protein belongs to?
Belongs to the Ycf2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: PROA_PELPD
Sequence: MTIAEQVAQIAHEARQASFVLSRLSTRVKNELLLAMAEALEQQAPHLIAENAKDLEEGKQKGLSSAMLDRLMLDAKRISAMADALREVAALPDPVGEVTKMWKRPNNLMVGKMRIPLGVIGIIFEARPNVTADAAALCLKAGNAVILRGGKEAINSNRAIAAILREAMVSKGVPAGALALIPFTDRQGVLEMLKQEECIDLIIPRGGEGLIRFVTENSRIPVIKHYKGVCHIFVDESADFDMAERIIINAKTQRPGVCNALETLLIHESVAAAFIPRIASILGGMQVELRGDERFRALAPQAKPASEEDWYAEYLELILACRVVDDLDQAIDHINRYGSLHTESIITSDYGRAQRFIREVNSSCVVVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGLEDLTTTKFIVYGDGQVRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FCNV3_CERRY
Sequence: MKPWAAFHLIFLVASSVEGDVSNYGTGGTQDTEPTCCTEHQCISDKIILQGQPGIPGIPGVPGINGSEGLKGDPGPQGLPGETGFDGIPGVAGPKGDKGDQGDKGDKGDKGDKGDACILDDCPPTDVEVRNCQDLLEHGEILNGWYTIYPTKENPMVVFCDMETDGGGWLVFQRRQDGSVDFYLDWESYKKGFGKQESEFWLGNDKIHLLTSSGTQQLRIDLEDFEGSRTFAKYSSFSIGDENEKYRLIVGSYLDGSMNDSFRIHNGHSFSTKDRDNDTNKGNCAMMYKGAWWYFHCHHANLNGLYYKGKHANYADGINWRSGKGYYYSYKYADMKIRPQQSETTVS
What is the function of this protein?
Initiates complement activation and/or interferes in platelet aggregation and/or blood coagulation.
What are the official names of this protein?
Ryncolin-3.
What is the protein family that this protein belongs to?
Belongs to the ficolin lectin family. Veficolin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UNC58_CAEBR
Sequence: MFFYSPNVASSSSASHRRGTLTHQHHLHVGHLDTRLSVQIPEILSRNFGHHDPERARLVPEHLRFLVDENQELWTGGNQPPVGILELCAASPVDSVFSTNDARRHSQRKLILRRPTISIQEDGKIIIDHVTARWEGANINSQSALLDADDGATVITDTIKDDQEDKEPKSCPQQTVKYIKILLPHVILVSVLIGYLCLGAWILMLLETRTELLSRSKKLVRLTNLMSNFTAESWRMLSDAQHGSITMDEGEWAATFREWMVRVSETVDDRRPIRRELNRPDDLSNMHNKWTFPTALLYVLTVLTTCGYGEVSVDTDVGKVFSVAFALVGIPLMFITAADIGKFLSETLLKFVSFWNRSVRKVKQWMSRVRHGRRKSLQSTGGQNDTLDILGVDGTEEKLWFPIGAYVSCICLYCSMGSAMFINWERTWSFIHAFHFGFNLIVTVGLGDIVVTDYIFLSLIVAFVIVGLSVVTMCVDLASTHLKAYFTRIHYFGRAKRFLGMSEELKEIVALLGAMRRKKGGKVTWNDVRDFLDNELRDRPFEPHELLMKLRFIDETSSGMSTIRHNSFQSDFFRESEYIRRVAALRPEQPAYL
What is the function of this protein?
Has a role in mobility, possibly in the transport of potassium in muscles.
What are the official names of this protein?
Uncoordinated protein 58.
What is the protein family that this protein belongs to?
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TYSY_LEGPC
Sequence: MKTYLQLLEHILQQGVEKSDRTGTGTLSVFGYQMRFDLTKGFPLVTTKKLHTRSIVHELLWFLRGDTNISYLKENGVTIWDEWADNNGDLGPVYGKQWRSWPTADGHTIDQLSDVVQQIKSNPDSRRLIVSAWNVGELDKMALMPCHALFQFYVANNKLSCQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWTGGDCHLYLNHLEQAQIQLTREPLPLPSLTIKRKPASLFDYAYEDFEFVNYQSHPAIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_COXB2
Sequence: MDINASLIVQMLVFVVFIGLTMKFIWPPLTKALEARRKNIADGLAAAEEGRKELELAEIKSKEQLTEAKTQAAHIIEQANQRANHIVEEAKNKAREEGAHLIQLAKNEIEQEYNAAKTELLKQISTIAVAGAQKILQREVDKASNDRLVDELVSEI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RNC_STAA8
Sequence: MSKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLKQIK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_AERPE
Sequence: MPKFKQVKNLKIPGVEPPEKVCSDPNCPWHGTLRVRGVLLEGVVAKARARRMVVVQHVYLYYDKKYNRYERRSKKIHAHLPDCISVKEGDVVVIGETMPISKTVKFTVLGVKRR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: CRI3_CAEEL
Sequence: MNTASLVRSLSRVALRSSQVVRMAAPRHFSQSAKVLSVTPELQQALNREIEAEQQLSSDNLQGAVAPTFAGFQVTNKDAEVRLTKKNGSEDILVVFNVNHSVDMDEGFDDEPSQAVAPVPVAMPPFTVEITKGDQRLCFHLELVPVDDQPDEYDFRVEEFYVAPSAKNGNEDVPSEVYASSGKYIDPDLHDLLFVRYLEERGLDARFCKTLVAYATHYEHSQYVGLLDKIKKFISK
What are the official names of this protein?
Conserved regulator of innate immunity protein 3.
What is the protein family that this protein belongs to?
Belongs to the MAM33 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: THI5_CANAW
Sequence: MSTNKITFLLNWEAAPYHIPVYLANIKGYFKDENLDIAILEPSNPSDVTELVGSGKVDMGLKAMVHTLAAKARGFPVTSIGSLLDEPFTGICYLEGSGITSDFQSLKGKRIGYVGEFGKIQVDELTKHYGMTPDDYVAVRCGMNVAKYILEGTIDCGIGIECIQQVELEEALKEQGKDSNDAKMLRIDKLAELGCCCFCTILYIANDKFIAENPQAVKKFLKAIKRATDYMLAHPREAWAEYGNFKPTMQTDLNTKKFQRCYAYFSESLYNVHRDWRKVNNYGKRLDILPENYVPNYTNEYLSWPEPKEVDDPEKAQDLMLKHQEECKTCGGYKRLVLA
What is the function of this protein?
Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway.  Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP).  The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.
What are the official names of this protein?
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase, HMP-P synthase, Hydroxymethylpyrimidine phosphate synthase, Thiamine biosynthesis protein 5, Thiamine pyrimidine synthase.
What is the protein family that this protein belongs to?
Belongs to the NMT1/THI5 family.
Protein: ALG2_MOUSE
Sequence: MAENLYRARSRVYSPSVLFLHPDMGIGGAERLVLDAALALQEYGCDVKIWTAHYDPNHCFIETRELSVQCAGDWLPRSLGWGGRGAAICSYVRMVFLALYVLFLSGEEFDVVVCDQVSACIPVFKLARRRKRVLFYCHFPDLLLTQRNSALKKFYRAPIDWIEEYTTGMADRILVNSQYTASVFKETFKTLSHRNPDVLYPSLNIGSFDLAIPEKIDDLVPKGKQFLFLSINRYERKKNLPLALRSLVQLRNRLPSQEWDKVHLFMAGGYDDRIPENVEHYKELKKMVQESDLERHVTFLRSFSDRQKISLLHGCLCVLYTPSNEHFGIVPLEAMYMQCPVIAVNNGGPLESIVHKVTGFLCEPDPVHFSEAMEKFIHKPSLKATMGLAGKARVAEKFSADAFADQLYQYVTKLV
What is the function of this protein?
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
What are the official names of this protein?
Alpha-1,3/1,6-mannosyltransferase ALG2, Asparagine-linked glycosylation protein 2 homolog, GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase, GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase, GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS19_LIMF3
Sequence: MGRSLKKGPFADASLLKKVEAQADSDKKTVIKTWSRRSTIFPSFIGYTFAVYDGRKHVPVYVQEDMVGHKLGEFVPTRTFRGHAADDKKTGRK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SWC5_YEAST
Sequence: MPEVETKIIPNEKEDEDEDGYIEEEDEDFQPEKDKLGGGSDDSDASDGGDDYDDGVNRDKGRNKVDYSRIESESGGLIKTRRARQAEEEYAKTHKYESLTVESIPAKVNSIWEELQEASKNRLLSSSGKVGSVLDGSKEARSTTAAQQEDKILIERNYKFAGETVHEKKWVSRSSAEGQEYLNSLKFKQQAPAAPVQLEKAVRTKSNESRQHLRRPLKRPPLLEQIISGGLRPKLTTLEKSQLDWASYVDRAGLNDELVLHNKDGFLARQEFLQRVGSAEDERYKELRRQQLAQQLQQDSEAS
What is the function of this protein?
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  Involved in chromosome stability.
What are the official names of this protein?
SWR1-complex protein 5.
What is the protein family that this protein belongs to?
Belongs to the SWC5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ENO_NOSS1
Sequence: MNNIVDTAIEAIVAREILDSRGRPTIEAEVHLLSGAVGLAQVPSGASTGTFEAHELRDKDKSRYGGKGVLKAVHNVNEILAPKLIDLDALNQELIDRTMIALDGSGNKSNLGANAILAVSLAAARAGAESLGIPLYRYLGGPLANLLPVPLMNVINGGAHASNNVDFQEFMIVPVGATSFREALRWGAEVFATLSEVLHDKGLLTGVGDEGGFAPNLESNQVALELLVAAIEKAGYKPGEQVALALDVAASEFYKEGQYVYDGRPHAPTEFIDYLGQLVDQYPIVSIEDGLHEEDWQHWQLLTQKVGSRVQLVGDDLFVTNATRLQKGIQEKAGNAILIKLNQIGSLTETLETIDLGTRNGFRSVISHRSGETEDTTIADLAVATRAGQIKTGSLCRSERVAKYNRLLRIEDELGDRAVYAGAVGLGPK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.