PharMolix/UniProtQA huggingface dataset:
Protein: EIF3H_SALSA
Sequence: MATRKESTSTPTAPMASTSPGATLDSPVKQIQIEGLVVLKMIKHYQEEGQGSEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVSRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEICKEKDFSAEGLKKAMIGFEHMFEEVPIVIKNSHLINVLMWELEEKCTVADKHELLNLSSSNHLEKSLQLLMDRVDDMSQDIVKYNTYSRNLSKQQQQKHQYTQRRQQENAQRQTRGETPLPEEDVSKMFKPPQPPPRMDTLLIAGQINNYCQNVKEFTSQNLGKLFMAEALQGHNS
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit H, eIF3h, Eukaryotic translation initiation factor 3 subunit 3, eIF-3-gamma, eIF3 p40 subunit.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCL2_CANLF
Sequence: MKVSAALLCLLLIAAALTTQVLTQPDAIISPVTCCYTLTNKKISIQRLASYKRVTSSKCPKEAVIFKTVLNKEICADPKQKWVQDSMAHLDKKSQTQTAKP
What is the function of this protein?
Acts as a ligand for C-C chemokine receptor CCR2 (By similarity).  Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity).  Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity).  Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity).  Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).  May play a significant role in monocyte trafficking into the reperfused myocardium (PubMed:9024159).
What are the official names of this protein?
C-C motif chemokine 2, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, MCP-1, Small-inducible cytokine A2.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROA_ECO8A
Sequence: MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARISQAA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_NEIMB
Sequence: MPRRREVPKRDVLPDPKFGSVELTKFMNVLMIDGKKSVAERIVYGALEQIEKKTGKVAIEVFNEAIANAKPIVEVKSRRVGGANYQVPVEVRPSRRLALAMRWVRDAARKRGEKSMDLRLAGELIDASEGRGGALKKREEVHRMAEANKAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: SMD_PARBP
Sequence: MQPLTRTICALFCLLLTLPLTFGSPFELEPRRNKLKIGTRIKQRRPTYAIAHMVLDKTGVKDAIKHGANALEIDVAAYRGGWWADHDMKAKSKGWSLESLFQVIAKENKHIAFVWLDLKTPDMCTGKKCNKKVLQPSKCKENEKCSMKSLQQLTRKYLKPAGVRVLFGFYKKHHARSAAFDYIQKSLGDGEAVCLSGEANKVMEIFKKEGSKIKPQRRVMDYGRTELPNGFGDCNEKGGKTCAELKNGAKLRQKGDLQRVFAWTSHVGEGKYVNKLLDKASVDGIIYGFAKTRYYHHKDTEKSSKDIIDRVKKSKSRYMVTGADKLW
What is the function of this protein?
Catalyzes the hydrolysis of sphingomyelin.  Sphingomyelinases D are produced by some spider in their venoms, but also by arthropods such as ticks, or pathogenic bacteria and fungi.  They might play a role in pathogenicity through different mechanisms, such as membrane destabilization and host cell penetration, but also pulmonary inflammation and cutaneous lesions.
What are the official names of this protein?
Sphingomyelinase D, SMase D.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelinase D/phospholipase D family.
What are the subcellular locations of this protein?
Secreted.
Protein: PORTL_BPML5
Sequence: MTAPLPGMEEIEDPAVVREEMISAFEDASKDLASNTSYYDAERRPEAIGVTVPREMQQLLAHVGYPRLYVDSVAERQAVEGFRLGDADEADEELWQWWQANNLDIEAPLGYTDAYVHGRSFITISKPDPQLDLGWDQNVPIIRVEPPTRMHAEIDPRINRVSKAIRVAYDKEGNEIQAATLYTPMETIGWFRADGEWAEWFNVPHGLGVVPVVPLPNRTRLSDLYGTSEITPELRSMTDAAARILMLMQATAELMGVPQRLIFGIKPEEIGVDSETGQTLFDAYLARILAFEDAEGKIQQFSAAELANFTNALDQIAKQVAAYTGLPPQYLSTAADNPASAEAIRAAESRLIKKVERKNLMFGGAWEEAMRIAYRIMKGGDVPPDMLRMETVWRDPSTPTYAAKADAATKLYGNGQGVIPRERARIDMGYSVKEREEMRRWDEEEAAMGLGLLGTMVDADPTVPGSPSPTAPPKPQPAIESSGGDA
What is the function of this protein?
Forms the portal vertex of the capsid.  This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection.  The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel.  Binds to the terminase subunits to form the packaging machine.
What are the official names of this protein?
Portal protein, Gene product 14, gp14, Portal vertex protein.
What is the protein family that this protein belongs to?
Belongs to the SPP1-like portal protein family.
What are the subcellular locations of this protein?
Virion.
Protein: RLMN_AZOC5
Sequence: MYAPMMPSPTAVAAPVAALSILPSLAGLDREKLGLALAAIGVPERERKMRVNQLWHWIYLRGATDFAEMTNVSKTLRTQLAEHYSLARPEIVVEQVSQDGTRKWLLRLPAETPGERPHEVEAVYIPERDRGTLCVSSQVGCTLNCAFCHTGTQRLVRNLTAAEIVAQVLVARDRLGDYPGRERAVGPGLPTEGDRLVTNIVFMGMGEPLYAYDSVAEAIEILADGDGLGLGKRRITVSTSGVVPEIEKLGREVGPMLAISLHAVRDDLRDVLVPINKKYPIAELMEACRTYPAASNAKRITFEYVMLKGVNDSPADARALVKLLEGVPAKINLIPFNPWPGTKYECSDWETIEKFSDIVFRAGYASPVRTPRGRDILAACGQLKSETEKLSARERLALRAMAAAAE
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_COXB2
Sequence: MTEFESAPAYQEAKYLTSAAEFDQLPPDQGAEIAFIGRSNAGKSSALNIITGIKGLARTSKTPGRTQMINFFALNEHERLVDLPGYGYAKVPRMVQKRWEELVDSYLKKRRCLKGLVVVMDIRHPLKEMDEDVIEWAVNYDIPIHILLTKSDKLSQNAAKKTLGEVQTAISAYGEKLTLQLFSSHDRTGLDEVKAVLSQWFRSEP
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: Y2551_ORYSI
Sequence: MAQNKTIAVALLLATLVAVMGKEPETLEEALRAGCKEECSEQKKKAPIDEKQREDFCFIKTKSIFEAHKGVKDLKADRFIDFCNNECNAVYKEDPATSKKCAESCEADAKEAEVFLDKVVAYMQTTKQA
What are the official names of this protein?
Uncharacterized protein OsI_009114, Unknown protein AN04 from 2D-PAGE of anther.
Protein: ROC1_ORYSJ
Sequence: MTPARRMPPVIGRNGVAYESPSAQLPLTQADMLDSHHLQQALQQQYFDQIPVTTTAAADSGDNMLHGRADAGGLVDEFESKSCSENVDGAGDGLSGDDQDPNQRPRKKRYHRHTQHQIQEMEAFFKECPHPDDKQRKELSRELGLEPLQVKFWFQNKRTQMKNQHERHENAQLRAENDKLRAENMRYKEALSSASCPNCGGPAALGEMSFDEHHLRVENARLRDEIDRISGIAAKHVGKPPIVSFPVLSSPLAVAAARSPLDLAGAYGVVTPGLDMFGGAGDLLRGVHPLDADKPMIVELAVAAMDELVQMAQLDEPLWSSSSEPAAALLDEEEYARMFPRGLGPKQYGLKSEASRHGAVVIMTHSNLVEILMDVNQFATVFSSIVSRASTHEVLSTGVAGNYNGALQVMSMEFQVPSPLVPTRESYFVRYCKNNSDGTWAVVDVSLDSLRPSPVQKCRRRPSGCLIQEMPNGYSKVTWVEHVEVDDSSVHNIYKPLVNSGLAFGAKRWVGTLDRQCERLASAMASNIPNGDLGVITSVEGRKSMLKLAERMVASFCGGVTASVAHQWTTLSGSGAEDVRVMTRKSVDDPGRPPGIVLNAATSFWLPVPPAAVFDFLRDETSRSEWDILSNGGAVQEMAHIANGRDHGNSVSLLRVNSANSNQSNMLILQESCTDASGSYVVYAPVDIVAMNVVLNGGDPDYVALLPSGFAILPDGPSGNAQAAVGENGSGSGGGSLLTVAFQILVDSVPTAKLSLGSVATVNSLIACTVERIKAAVCRDSNPQ
What is the function of this protein?
Probable transcription factor that may be involved in protoderm differentiation and radial pattern formation during early embryogenesis.
What are the official names of this protein?
Homeobox-leucine zipper protein ROC1, GLABRA 2-like homeobox protein 1, HD-ZIP protein ROC1, Homeodomain transcription factor ROC1, Protein RICE OUTERMOST CELL-SPECIFIC 1.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class IV subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: OR5M9_HUMAN
Sequence: MPNFTDVTEFTLLGLTCRQELQVLFFVVFLAVYMITLLGNIGMIILISISPQLQSPMYFFLSHLSFADVCFSSNVTPKMLENLLSETKTISYVGCLVQCYFFIAVVHVEVYILAVMAFDRYMAGCNPLLYGSKMSRTVCVRLISVPYVYGFSVSLICTLWTYGLYFCGNFEINHFYCADPPLIQIACGRVHIKEITMIVIAGINFTYSLSVVLISYTLIVVAVLRMRSADGRRKAFSTCGSHLTAVSMFYGTPIFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPMIYSLRNKDVKEAVNKAITKTYVRQ
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 5M9, Olfactory receptor OR11-190.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OTOP3_HUMAN
Sequence: MGRGARAAAAQSRWGRASRASVSPGRTIRSAPAVGEAQETEAAPEKENRVDVGAEERAAATRPRQKSWLVRHFSLLLRRDRQAQKAGQLFSGLLALNVVFLGGAFICSMIFNKVAVTLGDVWILLATLKVLSLLWLLYYVASTTRRPHAVLYQDPHAGPLWVRGSLVLFGSCTFCLNIFRVGYDVSHIRCKSQLDLVFSVIEMVFIGVQTWVLWKHCKDCVRVQTNFTRCGLMLTLATNLLLWVLAVTNDSMHREIEAELGILMEKSTGNETNTCLCLNATACEAFRRGFLMLYPFSTEYCLICCAVLFVMWKNVGRHVAPHMGAHPATAPFHLHGAIFGPLLGLLVLLAGVCVFVLFQIEASGPAIACQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTVKNPTRSLDVVLLMGAALGQMGIAYFSIVAIVAKRPHELLNRLILAYSLLLILQHIAQNLFIIEGLHRRPLWETVPEGLAGKQEAEPPRRGSLLELGQGLQRASLAYIHSYSHLNWKRRALKEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYQIWFAIVNFGLPLGVFYRMHSVGGLVEVYLGA
What is the function of this protein?
Proton-selective channel that specifically transports protons into cells.  Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.
What are the official names of this protein?
Proton channel OTOP3, Otopetrin-3.
What is the protein family that this protein belongs to?
Belongs to the otopetrin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KITH_XANOM
Sequence: MAKLYFYYSAMNAGKTTTLLQSAHNYRERGMRTLILTPKLDHRAGSGVVASRIGLRADGRIFERDTGLQQLVERDIHNDGALHCVLVDEAQFLSRAQVWQLSEVVDRLRVPVLCYGLRTDFRGELFEGSQFLLAWADELEEIKTICHSGSKATMTVRVDAQGHAVQDGPQVEIGGNERYVSVSRAEFKKIMRGEGRIDPLQIALPLPVA
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_BIFAA
Sequence: MTMTNRDDSEQLAWDFDAPESDGSSAAVVADEGLASLTPGSERWIAALQPTDADAMRLDKVDVASMSAEAAARLWARVAAWVESDQIAYYIDDAPVSSDAAYDARLRCLQSLEAQFPSLDSPQSPTHRVGGTFSNDFASVRHPSRMMSLDDVFSIEELREWYDGVLRGLDWPESKPLPMTCEVKIDGLALNLIYRNGVLEQGLTRGDGVTGEDITLNVRTISTIPQNLAGPEEDIPEFVEIRGEVFMRWDDFNKLNAENEDAGRAPFANPRNAAAGSLRQKDPRITATRRLSFYAHGIGSLRWGAGHAGNGHDVVNDQSEAYELYKKWGVPVSPHNREVTSFKEILDMIDYYGEHRGDIEHALDGIVVKVDDLGLQRSLGATSRAPRWAIAYKYPPEEVNTELLDITVQVGRTGRVTPVAVLKPVYVAGSTVSRTTLHNPFEVERKGVLIGDTVVVRKAGDVIPELVGPVLERRKGREGELRRFVMPTRCPSCGAELAPAKEGDKDIRCPNVESCPAQLTERIINLASRKAFDIEHLGDQSAIALTNPEEDRPDSIDTYAPNITEIVVKPGEEPEPYEPVAGLELPPMQTPVLSSEAGLFSLTSADLKDVRVWREAPIIEIHETVGSNGKIKKVRKRVGGSGLWHQVPAFWTAPTAARKRKEADIDETAEYPQYVVPDDAVVIREEIKVSRGGTSSVQPVYIRPAENTRKMLDEMDKARHADLWRVLVALSIRRLGPPTARTIASAFGTLDAIEHASVDELSQIDGIGSEIAESVVTWFTAAREPGNWRGAVLDAWKAAGVGVGQAQASGLPQTLAGKTVVVTGSLEGFSRDSAKEAIVLRGGKAAGSVSKKTDWVVVGENAGSKAAKAEELGIPMLNEDQFKQLLDTGTVE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: KAD_DESAL
Sequence: MRILFFGPNGSGKGTQGSIVKGKYNIPHIESGAIFRENISKGTEIGKKAKEYIDRGDLVPDEITIPMILGRLQADDCGNGWLLDGFPRSKEQAIKLDEALKEAGMALDVVIEMILDRQIAKNRIMGRRLCENDNNHPNNIFIDAIKPDGDKCRVCGGALSARSDDQDEDAIDKRHNIYYDTDTGTLASAYYFKAIAEKDGSVKYITLNGEPSVPEVTDELVGKLG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCPTX_MOUSE
Sequence: MQALLFLMALLLPSGAGAEEIIGGVESEPHSRPYMAYVNTFRRKGYVAICGGFLITPQFVMTAAHCRGRRMTVTLGAHNVRKRECTQQKIKVEKYILPPNYNVSSKFNDIVLLKLKKQANLTSAVDVVPLPGPSDFAKPGTMCWAAGWGRTGVKKIISHTLREVELKIVGEKACKIFRHYKDSLQICVGSSTKVASVYMGDSGGPLLCAGVAHGIVSSGRGNAKPPAIFTRISPHVPWINRVIKGK
What are the official names of this protein?
Mast cell protease-like protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Granzyme subfamily.
Protein: RL6_BACLD
Sequence: MSRVGKKLLEIPSGVTVTLNDNTVTVKGPKGELTRTFHPDMKIKIEDNVLTVERPSDNKEHRALHGTTRSIIGNMVEGVSKGFERGLELVGVGYRASKSGNKLVLNVGYSHPVEIVPENGIEIEVPSQTKVVVKGTDKERVGATAANIRAVRSPEPYKGKGIRYEGEMVRRKEGKSAK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SYR_CERS1
Sequence: MNLFTEIRTLVTAELGAMTEAGDLPAGLDLSAVAVEPPRDPAHGDMSTNAAMVLAKPSGKPPRAIAEALATRLAADPRISSAEVAGPGFLNLRLRPAVWQGMVATILQAGDTYGRSTIGAGQKVNVEFVSANPTGPMHVGHVRGAVVGDALARLLAYAGWNVTREYYINDGGAQVDVLARSAFERYREAHGLEPEIREGLYPGDYLIPVGEALKAKYGDSLLDKGEQHWLKEVREFATEMMMQMIREDLAALGVEMDVYSSEKALYGTGKIEAALDRLKEMDLIYEGVLEPPKGKTPEDWEPREQTLFRSTAHGDDVDRPVKKSDGSWTYFAPDIAYHYDKVTRGFDQLIDIFGADHGGYVKRMKAAVAALSAGRVPLDIKLIQLVKLWKNGEPFKMSKRAGTYVTLRDVVEQVGTDVTRFVMLTRKNDATLDFDFDKVLEQSKENPVFYVQYANARINSVLRKAREQGMDVSDATLATADLDRLDHPAEIALIAKLAEWPRLVEIAARTNEPHRVAFYLHELASELHGLWNRGNDEAGLRFLQDDPVVSQAKIALARAVGVVICAGLGILGVTPVEEMR
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATC_ASPTN
Sequence: MRVFPTYIAVSGLFGGAFAAFGATNIKGQTKLFGTSFGILAKNASYDYVIVGGGTAGLTVAARLAAQPNVSVAVIEAGSFYEIDNGNISQVPGYGANYLSFNDLTPSPVLVDWGLITEPQDGLNNRQIHYSAGKTLGGRATKGSYQRWAELVDDDTYTWDKLLPYLKKSVDFTKPKDAATYPYDASVYSPEGGPLQVSFPNYRAPCDDFMETAFTKSGLKPIKGLNSGHLDGFAPTTFVINPADQTRSSSEAAFLQEALDTTAMTLYLRTLAKKILFDTNKTANGVLVETNGAEYTISAKKEVILSAGVFHSPQLLLLSGIGQADSLEKFGIPVISDLAGVGQNLWDHLFIFTSHEMNITTNSGVLVDPELLAEAVESYLNQQTGPLTGIGGGVVGWEKLPNRVSFSNSTNETLASFPDDFPEVEYVALAPGSNPASDPLANHFASVTAAVQSTSSRGYVKLRSADPHDAPIININALSHPADADLAVGAIKRLRQIAEATGVRVKEVLPGPEVVSDAEILEWVRNNAVNGYHASSTCAMGNSSNPDAVVDTRAKVYGVSNLRVVDASALPYLPPGHPMSSIYAFAELIAEDILSK
What is the function of this protein?
Cyclase; part of the gene cluster that mediates the biosynthesis of terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase (PubMed:24534845, PubMed:25265334).  The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the 6-methylsalicylic acid synthase atX (PubMed:9003280, PubMed:9438344, PubMed:25265334).  In the biosynthesis of 6-MSA, atX utilizes one acetyl-CoA and three malonyl-CoAs as its substrates and catalyzes a series of programmed reactions including Claisen condensation, dehydration, reduction, and cyclization to yield 6-MSA (PubMed:9003280, PubMed:9438344, PubMed:25265334).  The 6-methylsalicylic acid decarboxylase atA then catalyzes the decarboxylative hydroxylation of 6-MSA to 3-methylcatechol (PubMed:25265334).  The next step is the conversion of 3-methylcatechol to terremutin via several oxidation steps involving the cytochrome P450 monooxygenase atE and probably also the cytochrome P450 monooxygenase atG (PubMed:25265334).  Lastly, atC is required for the oxidation of terremutin to terreic acid (PubMed:25265334).  No function could be assigned to atD yet, although it is involved in the biosynthesis of terreic acid (PubMed:25265334).
What are the official names of this protein?
Cyclase atC, Terreic acid biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: PHNC_STAA8
Sequence: MSQIEFKNVSKVYPNGHVGLKNINLNIEKGEFAVIVGLSGAGKSTLLRSVNRLHDITSGEIFIQGKSITKAHGKALLEMRRNIGMIFQHFNLVKRSSVLRNVLSGRVGYHPTWKMVLGLFPKEDKIKAMDALERVNILDKYNQRSDELSGGQQQRISIARALCQESEIILADEPVASLDPLTTKQVMDDLRKINQELGITILINLHFVDLAKEYGTRIIGLRDGEVVYDGPASEATDDVFSEIYGRTIKEDEKLGVN
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TPS_MATON
Sequence: MEGLVNNSGDKDLDEKLLQPFTYILQVPGKQIRAKLAHAFNYWLKIPNDKLNIVGEIIQMLHNSSLLIDDIQDNSILRRGIPVAHSIYGVASTINAANYVIFLAVEKVLRLEHPEATRVCIDQLLELHRGQGIEIYWRDNFQCPSEDEYKLMTIRKTGGLFMLAIRLMQLFSESDADFTKLAGILGLYFQIRDDYCNLCLQEYSENKSFCEDLTEGKFSFPIIHAIRSRPDDRQVIQILRQRTRDVEVKKYCVTLLEKFGSFSHTRETLAQLDREAREEVARLGGNPFLEAILNDLLNWDRTK
What is the function of this protein?
Terpene synthase that is able to convert geraniol diphosphate to geraniol in tea leaves.
What are the official names of this protein?
Terpene synthase, EoTPS.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: Y2229_CERS5
Sequence: MKITWLGHSGFRIEIEEAVLLVDPWLSGNPMFPIERRDEAIAGATHILLTHGHGDHSGDAVAIASELGLPIVGIYDLVTWLQSRDGVDGIGFNKGGTVTLDGARVTMVHATHSSSIMGEAGPVYTGTESGYMIAGEGHVIYASGDTDIMADMGWMGEYHRPDIGILAAGGHFTMDMKRAAFAARKYFDFRTVIPCHYRTFPLLEQSAEALRQGLPGVEVLEPEVLEPITI
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Rsph17025_2229.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: COXX_AGRFC
Sequence: MTVIDDRDMMGAESSELSEAGARDYFELLKPRVMSLVVFTAFAGLVLAPGEINPILGLIAILCIAVGAGASGALNMWYDADIDAVMTRTAKRPIPSGRIAPREALAFGLTLSAFSVVILGLAVNWFSAGLLAFTIFFYAVVYTMWLKRSTPQNIVIGGAAGAFPPMLGWACVTGGVSLDSVILFLIIFLWTPAHFWALALFKMRDYGAVGIPMMPNVAGERSTKNQMIVYAVLTAAAAVAPFFTGLASAGYGIFAAVLSAIFVYCSFDVRRMPEGDEKMLPAKKMFAYSVLYLFAIFSGLLADHFAPALKAVISGVL
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y108_OSHVF
Sequence: MHRVKAFKNLRLLITGKKEEKNKKPVEIPARDIAANYCSRHEYDWGMFVKNENPFRGITYQSYNAFKLRRFIPDMNQEDHKEYLFLAEQAEQEALKQELKEQDLYTMIEEISDDDVFTNPTMTDLAEKLGLEDESDDDDSGINFDVSTLADEDTLYQREILDREERRKENNISNESVSEEPESPLFNDKGRIVNCSTCIYNNKLQKRGGYGVEEYAEHYVFPDDKDDNLVCLLSDADRVIREIENSNFDIEGFEQSIDYDMLIHDELFIS
What are the official names of this protein?
Uncharacterized protein ORF108.
Protein: SDHA_PONAB
Sequence: MSGVRGLSRLLSARRLALAKAWPTVLQTGARGFHFTVDGNKRASAKVSDSISAQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVSTGKVTLEYRPVIDKTLNEADCATVPPAIRSY
What is the function of this protein?
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).  Can act as a tumor suppressor.
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, Flavoprotein subunit of complex II, Fp.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RS3_RUBXD
Sequence: MGQKVHPEGFRLGVRRKGEKVDFKSQWYSDRDFAELLGEDLKIREHIERKLARAGIAEIEIKKAAEQGEVVVDIHTARPGIVIGKGGSEVDALRRDLERLTSKKVQVNVREVSRPELNAKLVAESIAEQLEGRAAFRRTMKRALTSAMRSGAVGARIQCSGRLGGIEMSRSETVSEGKVPLHTLDADIDYGFKEANTQMGQIGVKVWINHGIHTDEER
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: ATPD_LEPBJ
Sequence: MNDSGVSKIYASALLGAVNSPEEVEQELGDLVQLLFKEEKIRNFFLSPTVSIEEKENILEKNLRGKILDVTLNFLGVLLNKGRFINLPEIQKRFTVELDKKKGRVRAQIKSYPSLEPAQITKLGSILSEKFKSEFILEVSEDKTLLGGFVVQFNDLKIEKSIASQLGEIKKAMLEKKLPVGAVYEN
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.