PharMolix/UniProtQA huggingface dataset:
Protein: LAP1_ASPSO
Sequence: MRFLPCIATLAATASALAIGDHIRSDDQYVLELGPGETKVVTEAEKWALRAEGKRFFDITGRTSSLELASNKKQKLAVTYPDSVQHNETVQNLINSLDKKNFETVLQPFSEFHNRYYKSDNGKKSSEWLQGKIQEIISASGAKGVTVEPFKHFFPQSSLIAKIPGKSDKTIVLGAHQDSINLNSPSEGRAPSADDDGSGVVTILEAFRVLLTDEKVAAGEAPNTVEFHFYAGEEGGLLGSQDIFEQYLQKSRDVKAMLQQDMTGYTKGTTDAGKPESIGIITDNVDENLTKFLKIIVDAYCTIPTVDSKCGYGCSDHASATKYGYPAAFAFESAFGDDSPYIHSADDTIETVNFDHVLQHGRLTLGFAYELAFADSL
What is the function of this protein?
Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.
What are the official names of this protein?
Leucine aminopeptidase 1, Leucyl aminopeptidase 1, LAP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28E subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RHG07_RAT
Sequence: MCRDEPDTMILTQIEAKEACDWLRVTGFPQYAQLYEDLLFPIDIALVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSEDSDEEEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDPIPGSPDNSRLQSATSRESMLTDLSEHQEVSSIRSLSSTSSSAPTHVPHSGEATTPRTNSVISVCSSSHFVGNEDSFSSLPSPKELSSFSFSMKGHEKNTKSKTRSLLKRMESLKLKGSHHSKHKAPSKLGLIISAPILQEGMDEEKLKQLNCVEISALNGNHINVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSTCNKRVGMYLEGFDPFSQSAFNNVTEQNYKNRESYPEDTVFYIPEDHKPGTFPKALSNGSFCPSGNSSVNWRTGSFHGPGHLSLRRENSSDSPKELKRRNSSSSVSSRMSIYDNVPGSILYSSSGELADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDHDRRTPSDLDSTGNSLNEPEEPTDIPERRDSGVGASLTRCNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRSGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNESAEDYVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSHVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSRCRNSYTEQELKPLTLEALGHLSNDQPADYRHFLQDCVDGLFKEVKEKFKGWVSYPTSEQAELSYKKVSEGPPLRLWRATIEVPAAPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPRGACALLFTSVDHDRAPVAGVRVNVLLSRYLIEPCGSGKSKLTYMCRADLRGHMPEWYTKSFGHLCAAEVVKIRDSFSNQSTESKDTRSR
What is the function of this protein?
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling.  This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation.  Also functions in vivo as an activator of the phospholipase PLCD1.  Active DLC1 increases cell migration velocity but reduces directionality (By similarity).  Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (By similarity).  The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (By similarity).
What are the official names of this protein?
Rho GTPase-activating protein 7, Deleted in liver cancer 1 protein homolog, DLC-1, Rho-type GTPase-activating protein 7, START domain-containing protein 12, StARD12, StAR-related lipid transfer protein 12, p122-RhoGAP.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
Protein: RL5_CLOBH
Sequence: MMPRLQEKYEKEVVSALMDKFGYKNIMEVPKLEKIVINMGVGEAKENQKSLEAAVEDLAKITGQKPILTKAKKSVANFKIREDMPLGCKVTLRKQNMYEFADKLINVALPRVRDFSGVSSKSFDGRGNYAIGIKEQLIFPEIEFDKIDKIRGMDIIFVTTAKTDEEARELLRFLGMPFAR
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: Y538_BUCAP
Sequence: MNTKKTFKSALEFVHKFRRKNKIKREISDIEKKIRDNQKRILLLDNLNQYITPDMNYEEIKKIIFMMKNDYEDRIDDYIVKNAELSKEKRSLSKELKLIVD
What are the official names of this protein?
UPF0265 protein BUsg_538.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: PCP_PECAS
Sequence: MKTVLITAFEPFEGEAINPSWEAVKDLHQREVGGVRVVACRLSCVFDLSLDQLYRAIAEWQPEVVIAVGQAGGRADISVERVAININDARIADNRGNQPIDTPVVEKGPAAYFSTLPVKALVQALHVAGIPASVSQTAGTFVCNHVMYGLLHQLHQQGDVVRGGFVHIPYSPEQAARHPGEPSMPTPLVTAALEVMIKQLLVQQVDVAITGGALH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2468_OCEIH
Sequence: MNQEQETKLVIITGMSGAGKTVAIQSFEDLGYYCVDNLPPALLPKFLDLMKDATNNIQKVALVMDLRGREFFDSLFEALDVLAKENWLEDHILFLDAKDEALVTRYKETRRSHPLATDGLPLDGIKQEREILDELRGRAQRIIDTTSLKPRNLREKILKVYKEEKQEVFSVHFVSFGFKYGLPIDADLVFDVRFLPNPHYVSNLQPLTGLNPDVSSYVFKWSDTQTFIDKVTDLLTFMLPQYKKEGKSQLVVAIGCTGGQHRSVALAEHFSKVLSNGYTTHVSHRDIDKRKVL
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein OB2468.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: RS8_STRP7
Sequence: MVMTDPIADFLTRIRNANQAKHEVLEVPASNIKKGIAEILKREGFVKNVEIIEDDKQGVIRVFLKYGPNGEKVITNLKRVSKPGLRVYKKREDLPKVLNGLGIAILSTSEGLLTDKEARQKNVGGEVIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: URE1_RHOP5
Sequence: MSIKISRSLYADMFGPTTGDRVRLADTDLIIEVEKDFTVYGEEVKFGGGKVIRDGMGQSQVTNAEGAVDTVITNALIVDHWGIVKADVAIKDGLIHAIGKAGNPDIQPGVTIIIGPGTDVIAGEGKILTAGGFDSHIHFICPQQIEHALMSGVTTMLGGGTGPSHGTFATTCTPGPWHIGRMMQSFDAFPVNLGISGKGNASRPAALQEMIEAGACALKLHEDWGTTPAAIDNCLSVADDYDIQVMIHTDTLNESGFVEDTIKAFKGRTIHAFHTEGAGGGHAPDIIKVAGLKNVLPSSTNPTRPFTKNTIDEHLDMLMVCHHLDPSIAEDLAFAESRIRKETIAAEDILHDLGALSMMSSDSQAMGRLGEVITRTWQTADKMKKQRGSLPQDSGDNDNFRVKRYIAKYTINPAIAHGVSKLIGSVEQGKMADLVLWSPMFFGVKPDCIVKGGMIVAAPMGDPNASIPTPQPVHYQPMFGAFGGALTASSVVFCSQAAIAGGLARKLGIAKKLYAVENTRGGISKKSMIHNDATPAIEVDPETYEVRADGELLTCAPAEVLPLAQRYFMY
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUTC_TREDE
Sequence: MKNIKIEICAGSFEDAVLAEKAGASRIELNSSLFLGGLTPSLGTLKLVKKETHLEVMAMVRPRAAGFFYSSYEYKTMLEDAKLFIDNGADGLVFGFLKKDGTIDAKRCEALIKIAESRDKVFHRAIDVVPDPLKALDELISLGFTRVLTSGQEPTAYEGADLIAKMVKRAKGRIEILPGGGITEKNASKIIKLTGVDQIHFAALKRREEPSTKANPSIYYGGALYPPEDSIEVAGLDEMTKVIKSL
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO3B_MYCGE
Sequence: MKILINKSELNKILKKMNNVIISNNKIKPHHSYFLIEAKEKEINFYANNEYFSVKCNLNKNIDILEQGSLIVKGKIFNDLINGIKEEIITIQEKDQTLLVKTKKTSINLNTINVNEFPRIRFNEKNDLSEFNQFKINYSLLVKGIKKIFHSVSNNREISSKFNGVNFNGSNGKEIFLEASDTYKLSVFEIKQETEPFDFILESNLLSFINSFNPEEDKSIVFYYRKDNKDSFSTEMLISMDNFMISYTSVNEKFPEVNYFFEFEPETKIVVQKNELKDALQRIQTLAQNERTFLCDMQINSSELKIRAIVNNIGNSLEEISCLKFEGYKLNISFNPSSLLDHIESFESNEINFDFQGNSKYFLITSKSEPELKQILVPSR
What is the function of this protein?
Confers DNA tethering and processivity to DNA polymerases and other proteins.  Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA.  Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity.  The beta chain is required for initiation of replication as well as for processivity of DNA replication.
What are the official names of this protein?
Beta sliding clamp, Beta clamp, Sliding clamp, Beta-clamp processivity factor, DNA polymerase III beta sliding clamp subunit, DNA polymerase III subunit beta.
What is the protein family that this protein belongs to?
Belongs to the beta sliding clamp family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAVL1_ARATH
Sequence: MEYSCVDDSSTTSESLSISTTPKPTTTTEKKLSSPPATSMRLYRMGSGGSSVVLDSENGVETESRKLPSSKYKGVVPQPNGRWGAQIYEKHQRVWLGTFNEEEEAASSYDIAVRRFRGRDAVTNFKSQVDGNDAESAFLDAHSKAEIVDMLRKHTYADEFEQSRRKFVNGDGKRSGLETATYGNDAVLRAREVLFEKTVTPSDVGKLNRLVIPKQHAEKHFPLPAMTTAMGMNPSPTKGVLINLEDRTGKVWRFRYSYWNSSQSYVLTKGWSRFVKEKNLRAGDVVCFERSTGPDRQLYIHWKVRSSPVQTVVRLFGVNIFNVSNEKPNDVAVECVGKKRSREDDLFSLGCSKKQAIINIL
What is the function of this protein?
Transcriptional repressor of flowering time on long day plants.  Acts directly on FT expression by binding 5'-CAACA-3' and 5'-CACCTG-3 sequences.  Functionally redundant with TEM2.
What are the official names of this protein?
AP2/ERF and B3 domain-containing transcription repressor TEM1, Protein TEMPRANILLO 1, RAV1-like ethylene-responsive transcription factor TEM1.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. RAV subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS4X_MESAU
Sequence: MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S4, X isoform.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: HSLV_SACD2
Sequence: MEQYRGTTILSVRRGNKVVIGGDGQVSLGNTIMKGNACKVRRLYKNQVIAGFAGGTADAFTLFERFEAKLEAHDGQLVRAAVELAKDWRTDRALRRLEALLAVANKDASLIVTGNGDVIQPENDLIAIGSGGAFAQSAARALLENTELEARDIVEKSLGIAGDVCVYTNHHFTIEELSF
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3A_BOMMA
Sequence: MAVGKNKGLSKGGKKGVKKKIVDPFTRKDWYDVKAPSMFSKRQVGTTLVNRTQGTKIASEGLKGRVFEVSLADLQADTDAERSFRKFRLIAEDVQGRNVLCNFHGMDLTTDKLRWMVKKWQTLIEANIDVKTTDGYVLRVFCIGFTNKDSLSQRKTCYAQHTQVRAIRKKMCEIITRDVTNSELREVVNKLIPDSIAKDIEKACHGIYPLRDVCIRKVKVLKRPRFEISKLMELHGEGGGGKREAGDKSERPEGYEPPVQESV
What are the official names of this protein?
40S ribosomal protein S3a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGB_STRPC
Sequence: MSKNLLIELGLEELPAYVVTPSEKQLGERLATFLTENRLSFEDIQTFSTPRRLAVRVSGLADQQTDLTEDFKGPAKKIALDADGNFSKAAQGFVRGKGLTTDAIEFREVKGEEYVYVTKHEAGKPAKEVLLGVTEVLSAMTFPVSMHWANNSFEYIRPVHTLTVLLNDEALELDFLDIHSGRVSRGHRFLGTETTITSADSYEADLRSQCVIVDAKERQEMIVEQIKTLEVEQGVQVDIDEDLLNEVLNLVEFPTAFMGNFEAKYLDVPEEVLVTSMKNHQRYFVVRDQAGHLMPNFVSVRNGNDQAIENVIKGNEKVLVARLEDGEFFWREDQKLQIADLVAKLTNVTFHEKIGSLAEHMDRTRVIAASLAKEANLSAEEVTAVDRAAQIYKFDLLTGMVGEFDELQGIMGEKYALLAGEDAAVATAIREHYLPDAAGGALPETKVGVVLALADKLDTLLSFFSVGLIPSGSNDPYALRRATQGIVRILDHFGWRIPMDKLVDSLYDLSFDSLTYTNKADVMNFIRARVDKMMGKAAPKDIREAILASSTFVVPEMLAVAEALVKASHTENYKPAVESLSRAFNLAEKADASVQVDPSLFENEQENTLFAAIQGLTLAGSAAQQLEQVFALSPVINDFFDNTMVMAEDQALKNNRVAILSDLVSKAKTIAAFNQLNTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAT_ECOLU
Sequence: MNRLPSSASALACSAHALNLIEKRTLDHEEMKALNREVIEYFKEHVNPGFLEYRKSVTAGGDYGAVEWQAGGLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRKPFMPLLPGFRHVPFGNIEAMRTALSECKKTGDDVAAVILEPIQGEGGVILPPPGYLTAVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDMLLDGFRQLAREYPDLVQEARGKGMLMAIEFVDNEIGYNFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIEQCELVIKAARKALAAMRVSVEEA
What is the function of this protein?
Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline.  This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal.  Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Putrescine aminotransferase, PAT, PATase, Cadaverine transaminase, Diamine transaminase, Putrescine transaminase, Putrescine--2-oxoglutaric acid transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.
Protein: RLMH_CLOBB
Sequence: MNITIISVGKLKEKYLKHAIDEYSKRLSRYCKLNILELQDEQTPDNASEKDELIIKDKEGNKILNSIKDNMYVITLDLKGKMMSSEELSKFIDNCGVRGNSNLCFVIGGSLGLSEAVLKRSNHSLCFSKMTFPHQLFRVMLLEQIYRAFRISNGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBBA_PELPB
Sequence: MDKKNFDTIDAALEDIRQGKLVIVIDDEDREDEGDFIGAADKVTNEMVNFITREARGLLCVAVTMDRAKELQLDPMVQRNTSQHETNFTVSVDAIAEGVTTGISVYDRAMTIKMLGDLSSTADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLARLAGCSPTGLLCEILNDDGSMARLPQLIKLKAKFGLKLITIKELVAYQMQRNKLVQRAVESRLPTIYGEFRLIAYESFTDQHNHMAFVKGDVTTDEPVLVRVHSQCATGDTFASLRCDCGNQLASALTMIEKEGRGVLIYLMQEGRGIGLINKLKAYNLQDQGYDTVEANEKLGFKADLRDYGIGAQILKDLGVRKMKLMTNNPKKVVGLEGYGLEIVERVPLEMASNPMNQFYLDTKRDKLGHMIGCSFGPENFHIEKTATKP
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: UPP_BACMK
Sequence: MGKLYVFDHPLIQHKITYIRDKNTGTKDFRELVDEVASLMAFEITRDLPLEDIEIETPVSKATTKVIAGKKLGLIPILRAGLGMVDGILKLIPAAKVGHVGLYRDPKTLQPVEYYVKLPTDVEERDFIVLDPMLATGGSAAEAINSLKKRGAKQIKLMCIVAAPEGVKVVQEEHPDVDIYVAALDEKLNDHGYVVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: UBC8_SCHPO
Sequence: MSSPRRRIETDVMKLLMSDYEVTLVNDNMQEFYVRFHGPSETPYSGGIWKVHVELPSEYPWKSPSIGFVNRIFHPNIDELSGSVCLDVINQTWSPMFDMINIFEVFLPQLLRYPNASDPLNGEAAALLLREPNTYYAKVRDYIARYANKEDADITLNDSSDDDTMSSIDTESGDEIAGPMDSDF
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 8, E2 ubiquitin-conjugating enzyme 8, Ubiquitin carrier protein 8, Ubiquitin-protein ligase 8.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_DICT6
Sequence: MNIKIIVIGKIRNEFIKAGVNEYLKRLLPFINIKIEFLPSFSELSEKIALLKEEEIILKNLRNGEFIITLDKDGEKISSEEFSKKLFKLPISQNSQITFIIGGIYGVSEKIKQSSNFILSLSSMTFTHEFALLILLEQIYRALKIQRNEPYHY
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNPO2_MOUSE
Sequence: MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLTHEAERPDSSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEENWQQFSEQFPPLLKERLAAFYGV
What is the function of this protein?
Probably functions in nuclear protein import as nuclear transport receptor.  Serves as receptor for nuclear localization signals (NLS) in cargo substrates.  Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
What are the official names of this protein?
Transportin-2, Karyopherin beta-2b.
What is the protein family that this protein belongs to?
Belongs to the importin beta family. Importin beta-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DNAJ_BACAC
Sequence: MSKRDYYEVLGLSKGASKDEIKKAYRRLAKKYHPDVSKEENAIEKFKEVQEAYEVLSDDQKRAQYDQFGHAGANQGFGGFGGGGDFGGGFGFEDIFSSFFGGGGGRRRDPNAPRQGADLQYQVTLEFEEAIFGKELNVEIPVEDPCDTCKGSGAKPGTSKETCKHCSGSGQVSVEQNTPFGRIVNRQACSHCSGTGQMIKEKCTTCHGSGKVRKRKKINVKIPAGIDNGQQIRVSGKGEAGVNGGPAGDLYVVVHVRSHEFFEREGDHIICEMPLTFAQMALGAEVEVPTVHGKVKLKIPAGTQTGTEFRLKGKGAPNVRGYGQGDQYVVVRVVVPTKLTSHQKDLLREFAGQEEQDDSLFGKLKRAFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRLK_DICDI
Sequence: MIKLILSIILIICFIINSIESFKMITLTTGPPSDLGWNNMINLGRIGVTKAMDIEDSRLFVVSGRNDTYELLLPIIQNDDIDLVICSSLDHGDACKEIAAMYVNSTEIKTQFLVRGSGATTKNLIQFTYNYASVNYLSGMFAGLQTKTNKIGFISPGITAGASDCFVYAFWLGAKSVNPNIKFYYYNIGSYLDKDKTKGAAENLIDVYDCDVIGDTLDDFTASNVAISRGRYAIGTNGFPQRDVYGENVVYTYAYNWTKYFVPIASAVKNKIPPSKWYADFNKDNNLSLYDLSFGFQVSAETKFKIINQTKSFASYVRTLHPYFCNEYMEGYTQKYNLTRQPNTTNCITTTGFIGIDAPVGDMNYLGNYTIKFSKVEFQRSIQIGFSIVSGLLIGFVILMMIGIVKYQDTPSIRSASPSFLNLTLLGGVIIFIGIIVWVAPISTHQCNARFWLVTIGFSTLIGSLVVKNIRIWLIFDNPELKIRTITNNQLYPWVGLCLVINIVLMSIITTVGDLKAIEAQGIDSLGKFEYMTICKMNYTGAATLYSILAYFGTLLLVGVFVSWKIRIVHIEEFSECTAIAKTLYSISFCLFVIVPLMISPQDKQSETIILCVTGIFITTGALLIFFLPKFWRIFGNEKQGSHEHFTQRKQSAVASARAESANRNNSSNSFGFSKSSAQIGNTISGIESLNDDSNESSLSNETK
What are the official names of this protein?
Metabotropic glutamate receptor-like protein K.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y696_METJA
Sequence: MESILFIAIAFLINSFISYKITNMQPKIKSRIFKRVKMHYLNLIEGKKAEFDKKAMPILFGFMIIALISFNILLYVVYNCPVSITSIIAEILIIISMIIIWKAFNKEISVYLCDDGIYYSNKFISWKNIENVKKDDGFIVLFGKKKKILGRKLYLLQRIYLKYDEEIENIIKNQIEKFRDKA
What are the official names of this protein?
Uncharacterized protein MJ0696.
What is the protein family that this protein belongs to?
To M.jannaschii MJ0803.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.