PharMolix/UniProtQA huggingface dataset:
Protein: HEM6_PARPJ
Sequence: MTDSSYDAQAVRSWLQGLQTHIADTLGAFDGTPFATDAWQRAPGEKLRGGGYTRILEGGKFFERAGIGFSDVAGDALPGSASAARPQLAGRGFEAMGVSLVLHPHNPHCPTVHMNVRLLIATKPGEEPVFWFGGGMDLTPYYGYEEDARHFHRTCRDALQPYGADLYPSFKRWCDEYFFLKHRNEARGIGGIFFDDFSAPGFDQSFAMLKSVGDAFLKAYLPIVEKRRNIPYGQAERDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVVNWRYNWHPEPGTPEARLYSDFLVPREWV
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGLR1_PENOL
Sequence: MRTSILSMLALGAAAVSAAPAAAAAPAELVERGSSCTFTSASAAKAGKKSCSSIVLDNIKVPAGETLDLSNLKSGTKVTFKGETTFGYKEWKGPLIRFSGKNIEVNGASGHVINGGGASWWDGKGTNGGKTKPKFFYAHSLDDSTITGLNVKNTPVQGFSVQADNLVLDHITIDNTDGDKTNGGHNTDAFDVGESTYITISNANIKNQDDCLAINSGENIIFTGGTCSGGHGLSIGSVGGRDDNTVKNVTISDSTVSNSDNGIRIKTIYKAKGEVADVTFSNIELSNIAKYGIVIEQDYENGSPTGKPTTGVPITGLTVEKVTGSVKSSGTDVYILCGSGSCSDWTWSGNKVSGGKTSSKCKNVPSGASC
What are the official names of this protein?
Polygalacturonase 1, PG 1, Pectinase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SDHE_NITEU
Sequence: MNHQARMRWRCRRGMLELDIVLQRFIDNHYEQLDEHQLELFEMLLSLSDHDLWNIIIGNTKEPNNQFQPVLKLLQEN
What is the function of this protein?
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins.  Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
What are the official names of this protein?
FAD assembly factor SdhE.
What is the protein family that this protein belongs to?
Belongs to the SdhE FAD assembly factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACYP_ENT38
Sequence: MMSKVCTIAWVHGTVQGVGFRYSTQREALQLGLTGYARNLDDGSVEVVACGEADNIEQLIAWLKAGGPRSARVEKVFTEPHQPDREYDKFSIRY
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: SELU_VEREI
Sequence: MRQDDAQLRHIFLHDVPLLDVRAPVEFAQGAFPGAVNHPLMDDAERHQVGLCYRQQGQPAAIALGQQLVSGHTRRERIAAWAAFAQAHPDGLLYCLRGGLRSQIALQWLHSEAGIAYPRVPGGYKALRMFLIDTTQAAAQECDFVLLSGLTGTGKTALIAQLAQGLDLEGHANHRGSSFGQRLDGQPSQVDFEHRLAIDILKKQARGHRAFVLEDEGRHVGRCSVPLALRQRLERAPIVCLQDSFGARVERIVGDYVIGQCADFVAAHGPALGFERFSTRLLDSLGKLARRLGGARYQQLHADMQAALARQQASGDIDLHRHWIAALVRDYYDPMYAFQRQSRPGRIVFEGDLPAVLAYLRAGCG
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: YF052_YEAST
Sequence: MDGLVTQAKIQLRLFQLRMVQVQVLLLLLHCPKKELPKVSLLVSLALNEKNVMKYKCVFPSLNIIILMSDALMFFLRSSICKYRHTHIYIFMCIILANKHF
What are the official names of this protein?
Putative uncharacterized protein YFR052C-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y1032_STAA2
Sequence: MILGLALIPSKSFQEAVDSYRKRYDKQYSRIKPHVTIKAPFEIEDGDLDSVIEQVRARINGIPAVEVHATKASSFKPTNNVIYFKVAKTDDLEELFNRFNGEDFYGEAEHVFVPHFTIAQGLSSQEFEDIFGQVALAGVDHKEIIDELTLLRFDDDEDKWKVIETFKLA
What are the official names of this protein?
Putative phosphoesterase SaurJH1_1032.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. YjcG family.
Protein: SYY_UREU1
Sequence: MHNLIKDLKARNLINNITNEEKLKKALAENKGIYVGFDPSADSLHLGNYIMIMLLKRFRLHNIKTFALVGGATGMIGDPSGKSAERNLLDKTILEHNITKIKYQLEKFTNSQVINNYDFYKNMTFLDFLRDVGKLININYLLEKEIISSRLDVGISYTEFSYNLLQGYDFLQLYKNDNIAIQAGGSDQWGNITTGIEIIRKSLGDDNIACGLTINLLTNSEGKKFGKSEKGAIYLDENKSSVYEMYQFLINQTDADVEKLLNFLTLIDVDEINKIMQAHKENPALRIAQKALAQAVVVDVHGQQKYEQALHISQVLFNGNINELNQEEFNIAIKSLPTTKLDKDEIKIIDLLNLANISSSNRVARDFLSTGSILVNDIKVNDENFLVKKQDAINQEFSIIKKGKRNYFLIVWNKD
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZSC12_HUMAN
Sequence: MASTWAIQAHMDQDEPLEVKIEEEKYTTRQDWDLRKNNTHSREVFRQYFRQFCYQETSGPREALSRLRELCHQWLRPETHTKEQILELLVLEQFLTILPEELQAWVQEQHPESGEEVVTVLEDLERELDEPGEQVSVHTGEQEMFLQETVRLRKEGEPSMSLQSMKAQPKYESPELESQQEQVLDVETGNEYGNLKQEVSEEMEPHGKTSSKFENDMSKSARCGETREPEEITEEPSACSREDKQPTCDENGVSLTENSDHTEHQRICPGEESYGCDDCGKAFSQHSHLIEHQRIHTGDRPYKCEECGKAFRGRTVLIRHKIIHTGEKPYKCNECGKAFGRWSALNQHQRLHTGEKHYHCNDCGKAFSQKAGLFHHIKIHTRDKPYQCTQCNKSFSRRSILTQHQGVHTGAKPYECNECGKAFVYNSSLVSHQEIHHKEKCYQCKECGKSFSQSGLIQHQRIHTGEKPYKCDVCEKAFIQRTSLTEHQRIHTGERPYKCDKCGKAFTQRSVLTEHQRIHTGERPYKCDECGNAFRGITSLIQHQRIHTGEKPYQCDECGKAFRQRSDLSKHQRIHNRRGTYVCKECGKSFRQNSALTQHQTIHKGEKSVSV
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger and SCAN domain-containing protein 12, Zinc finger protein 305, Zinc finger protein 96.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YETM_BACSU
Sequence: MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGILQPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILRKTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSVVRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVFVLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWHKGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRALKVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY
What are the official names of this protein?
Putative FAD-dependent monooxygenase YetM.
Protein: PSBF_STIHE
Sequence: MTTANSEEKTYPIFTVRWLSVHALGIPTIFFLGAITAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RS12_PSYCK
Sequence: MATTNQLIRKGRKTIKEKSKVPALEACPQRRGVCTRVYTTTPKKPNSAMRKVCRVRLTSGYEVSSYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGALDCAGVKDRKQGRSKYGAKKPKV
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: CPPB_NEIGO
Sequence: MSKISDLAKTFEQTSRTEAASIEQQTKADLETLRKNINEALKQSEQKITADINARQLRMSKAVFKPYLWSLLGISAAGLIVIAGLFIAIWSVKNELDDLKQQRAEAERTLDLLETKTKGLTLENCPVENSKATRVCVATEKRMLDALAELESNHAAIEQRMMKALTHLGERLAELEQENTSLAQQLASLAAELERQSEIRQRQSEILNQPAKR
What are the official names of this protein?
Cryptic plasmid protein B.
Protein: CSRA_YERPN
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKSQPTTY
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_MACCJ
Sequence: MFDQLEIVEQRYEQLNELLSDPDIVSDTDKLREYSKEQADLQETVEVYREYKEVKQQLEEALEMMGEASDADEQEMIKEEINTLKPQIPELEERMKLLLIPKDPMDDKNVVMEIRGAAGGDEANIFAGDLFRMYSRFSEEQGWKIEVMETNEADHGGFKEISFIIIGKGAYSKLKFENGAHRVQRIPTTESGGRIHTSTATVAVLPEVEDVEIEIRQEDLRIETYRSSGSGGQHVNTTDSAVRITHIPTGIVATSSEKSQIKNREKALKLLKTRVFDAKLQEEQAKYSEQRKSAVGTGDRSERIRTYNYPQNRVTDHRIGLTIQKLDQIVEGKLGEIIDALTIAEQTSKLEALNDGVL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_RHOPT
Sequence: MPELPEVETVRRGLQPAMEGFRIDRAVAHRENLRFPLQKDFAARLTGQTVTGLGRRAKYLLADLSSGDVLLMHLGMSGSFRVIGADGETTPGEFHYPRSEDRTHDHVVFEMASGARVVFNDPRRFGFMKVFPRSEIETEPHLKGLGPEPLGNAFDASLLAKACAGKQTSLKAALLDQRVVAGLGNIYVCEALFRAHLSPKRKASTLANRKEEPTDHAVRLTEAIREVLGEAIKAGGSSLRDHRQTSGELGYFQHAFKVYDREGKPCPTCGGTVQRFVQNGRSTFWCPKCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: BGALC_ASPCL
Sequence: MRILSLLFLLLLGFLAGNRVVSATDHGKTTDVTWDRYSLSVKGERLFVFSGEFHYQRLPVPEMWLDVFQKLRANGFNAISVYFFWGYHSASEGEFDFETGAHNIQRLFDYAKEAGIYVIARAGPYCNAETTAGGYALWAANGQMGNERTSDDAYYAKWRPWILEVGKIIAANQITNGGPVILNQHENELQETSYEADNTLVVYMKQIARVFQEAGIVVPSSHNEKGMRAVSWSTDHHDVGGAVNIYGLDSYPGGLSCTNPSSGFNLVRTYYQWFQNSSYTQPEYLPEFEGGWFQPWGGHDYDTCATELSPEFADVYYKNNIGSRVTLQNIYMVFGGTNWGHSAAPVVYTSYDYSAPLRETREIRDKLKQTKLIGLFTRVSSDLLKTHMEGNGTGYTSDSSIYTWALHNPDTNAGFYVLAHKTSSSRSVTEFSLNVTTSAGAISIPDIQLDGRQSKIIVTDYQFGKSSALLYSSAEVLTYANLDVDVLVLYLNVGQKGLFVFKDERSKLSFQTYGNTNVTASVSSHGTQYIYTQAEGVTAVKFSNGVLAYLLDKESAWNFFAPPTTSNPQVAPDEHILVQGPYLVRGVTINHDTVEIIGDNANTTSLEVYAGNLRVKVVKWNGKAIKSRRTAYGSLVGRAPGAEDARISPPSLDSWSAQDTLPDIQPDYDDSRWTVCNKTASVNAVPLLSLPVLYSGDYGYHAGTKVYRGRFDGRNVTGANVTVQNGVASGWAAWLNGQFVGGVAGAIDLAVTSAVLSFNSSLLHDRDNVLTVVTDYTGHDQNSVRPKGTQNPRGILGATLIGGGKFTSWRIQGNAGGEKNIDPVRGPINEGGLYGERMGWHLPGYKAPRSAAKSSPLDGISGAEGRFYTTTFTLKLDRDLDVPIGLQLGAPAGTQAVVQVFMNGYQFGHYLPHIGPQSLFPFPPGVINNRGENTLAISMWALTDAGAKLDQVELVAYGKYRSGFDFNQDWGYLQPQWKDNRRQYA
What is the function of this protein?
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
What are the official names of this protein?
Probable beta-galactosidase C, Lactase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: THSB_SACS2
Sequence: MATATVATTPEGIPVIILKEGSSRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDGATILDKMDLQHPTGKLLVQIAKGQDEETADGTKTAVILAGELAKKAEDLLYKEIHPTIIVSGYKKAEEIALKTIQEIAQPVTINDTDVLRKVALTSLGSKAVAGAREYLADLVVKAVAQVAELRGDKWYVDLDNVQIVKKHGGSVNDTQLVYGIVVDKEVVHPGMPKRIENAKIALLDASLEVEKPELDAEIRINDPTQMHKFLEEEENILKEKVDKIAATGANVVICQKGIDEVAQHYLAKKGILAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAALVEERKVGEDKMVFVEGAKNPKSVSILIRGGLERVVDETERALRDALGTVADVIRDGRAVAGGGAVEIEIAKRLRKYAPQVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSLHENETNKWYGLNLFTGNPEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGKKSGSEPSGKKEKDKEEKSSED
What is the function of this protein?
Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
What are the official names of this protein?
Thermosome subunit beta, Chaperonin subunit beta, Thermophilic factor 55 beta, TF55-beta, Thermosome subunit 2.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
Protein: SETD6_XENTR
Sequence: MGPDAKKQKLQSEDHLQNDLPVSCFLAWCKKVGLELNPKVYISTEGTVSQYGMLAREDLSDGELLFSIPRSAILSQNTTRIRDLIEKEQDSLQSCSGWVPLLISLLYEATDSSSHWAPYFGLWPELDPPDMPMFWSEEEQTKLLQGTGILEAVHKDLKNIEKEYNSIVLPFIRRNPEKFCPMKHTLDLYKRLVAFVMAYSFQEPQEEDEEEDIEKDILPPMMVPVADLLNHVAQHNAHLEFTPECLRMITTKSVCAGQELFNTYGQMANWQLLHMYGFAEPHPQNCNETADIQMVTVREAAFQVARTEEDRLEMQKRWDFLCHIEIVGEEGAFVFGLEEVMTEEELKACLKVLCMSTDEFAEYKENDGWEEDEDNDEQTLLTQEISRLPIPWRKLLHLSAELTLKAYKTELSMDEALVNDPTAYAKLSSREQHSLQVQYGQKKILHLLLELTKS
What is the function of this protein?
Protein-lysine N-methyltransferase.
What are the official names of this protein?
N-lysine methyltransferase setd6, SET domain-containing protein 6.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRI1_CAEEL
Sequence: MSYNSIRLPQDLPIYYKNFFPVKPFTKWLRYGQNNGDYFNRREFAFILADDVHIRYRSYNDEHAFFKALSSTNPEKLDIGAVYNHEPINNKRHTDYQAVERELVFDIDLTDYDPVRNCCKDATVCPKCWKFMVLAVKILDFQLEDMFDFKARMWVFSGRRGVHCWVGDKKARMLNNYQRSAIATRLNLFKKNGQCEVTEGRAKMTKVPPIVRDAFNVALKDGVFEKMIYDQGWLDKEDFITEYKFMSEVGRDDLRSLSETYKTPQERWNMIRGLFDDDYRKSLSPKDGLLDFKMQGRDRNYLLYFVLQRCYPRLDVNVSTGTNHLLKSPFCIHPKTGNVAVPLNVGKIEEFDVSKCPRIDHVVEELSSLLAERGNDENEDSKNRKFLAYKHGALAPYVENFEKFVSACIS
What is the function of this protein?
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
What are the official names of this protein?
DNA primase small subunit.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: RS6_STAAN
Sequence: MRTYEVMYIVRPNIEEDAKKALVERFNGILATEGAEVLEAKDWGKRRLAYEINDFKDGFYNIVRVKSDNNKATDEFQRLAKISDDIIRYMVIREDEDK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: IMDH_DICDI
Sequence: MEKINKILQGTNSEYKSEWFVDGFDCFELFQQRHGYTYDDLIMLPGHINFSADDVSLKTKLTKNISLNAPLVSSPMDTVTEHLMAINMALLGGIGIIHYNNTVEEQVVEVKKVKRFKNGFITDPIVLSPTHKLSDVDMIKQKYGFSGIPITDTGRIGGKLVGIVTSRDTDFIKDRSTTLSEVMTTDLITGQQNCTLEEANSILKSCKKGKLPIVNDKGELVALASRDDLVKNRDFPMATKDHENKKLLVGAALGTRETDKERLAALSDAGVDVVILDSSQGDSTYQREMIRFIKRNYPKIDVIGGNVVTTSQCESLIQAGVDGLRVGMGVGSICTTQEVMACGRPQATAVFKCALYSSQYNVPIIADGGIRTIGHIIKGLSLGASSVMMGSMLAGTEEAPGDYFYKDGMRLKKYRGMGSLEAMVKGGDQRYFSETDKIKVAQGVSGSVVDKGSVKKFVPYLIQGIKHGLQDLGCNSVTNLRESVYGGKVRFEVRTAAAQVEGSVHSLFSYEKHFI
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_SHIBS
Sequence: MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELRKAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPFL_SALTY
Sequence: MDERIPCKNPQCSHFILPATAARTEGYCMPCVQARYRQVQEEYIRKNRKTIDAFSGITNPVEMLKLVHEPREHDPLIEWIPCPIPTDELYKKLSDDESRDMVDYAEELFDSGWQEEAQEIALCLAAFTQANLDNFLRQVINEEELELSSPLPFHRAPPDVRDALLQKVETDDENRDGILCALAWIGDEVVVEHFNRWRQEPPAWSASLHILPHRYAHQAGWELTENGRRRDLYFTQCTHLVKQAPEQPAVFRAVAEYGENCPHCSLPLINLFEVAPSAVGLSTQGWPGQIRILTCQCCTAYNTVFATVDPQGQPRWYEKNALSTLAVENSADWITLPLDVLHPGESRLPLFAAEIFLPTTFSQLGGHPAWVQDTDYPTCPTCAQTMMFLAQLSYEDIEEEEYAEGMLYGFICPSCQTTATSYQQT
What are the official names of this protein?
Uncharacterized protein YpfL, ORF79.
Protein: RSMH_BART1
Sequence: MTKQDQRAERHIPVLLQPVLAGLMPLVGAKVIDGTFGAGGYTRALLKAGAQVIALDRDPHAIAAGQSLVDEFFPRLRLVHMEFSQLDRVVEEKVDAVILDIGVSSMQLDEAERGFSFQKDGPLDMRMAQTGFSASDVVNHLKAKDLARIFKILGEERYAGRIARMIEKRRAVQPFLRTGDLAYAIEALVGRKPGDRIHPATRVFQALRIYVNDEIGELARGLFAAERVLKAGGRLGVVSFHSLEDRMVKRFFVSRSGEGMRSRHLPEIKHSPATFFPLFKGGITANKEELQQNPRSRSARLRMGVRTNAEALAEDMKLFGLAEIASFEGGKK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAS10_HUMAN
Sequence: MVGRSRRRGAAKWAAVRAKAGPTLTDENGDDLGLPPSPGDTSYYQDQVDDFHEARSRAALAKGWNEVQSGDEEDGEEEEEEVLALDMDDEDDEDGGNAGEEEEEENADDDGGSSVQSEAEASVDPSLSWGQRKKLYYDTDYGSKSRGRQSQQEAEEEEREEEEEAQIIQRRLAQALQEDDFGVAWVEAFAKPVPQVDEAETRVVKDLAKVSVKEKLKMLRKESPELLELIEDLKVKLTEVKDELEPLLELVEQGIIPPGKGSQYLRTKYNLYLNYCSNISFYLILKARRVPAHGHPVIERLVTYRNLINKLSVVDQKLSSEIRHLLTLKDDAVKKELIPKAKSTKPKPKSVSKTSAAACAVTDLSDDSDFDEKAKLKYYKEIEDRQKLKRKKEENSTEEQALEDQNAKRAITYQIAKNRGLTPRRKKIDRNPRVKHREKFRRAKIRRRGQVREVRKEEQRYSGELSGIRAGVKKSIKLK
What is the function of this protein?
Essential for gene silencing: has a role in the structure of silenced chromatin.  Plays a role in the developing brain (By similarity).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
What are the official names of this protein?
Something about silencing protein 10, Charged amino acid-rich leucine zipper 1, CRL1, Disrupter of silencing SAS10, UTP3 homolog.
What is the protein family that this protein belongs to?
Belongs to the SAS10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIA40_CRYNB
Sequence: MFARSFSNASRTIARRSLSTRSGPAPSSLWSSRNAVIAGTTLAITALAVTSERRKVFNESAQKATSPRDSIIAQDSLKENVHKKSVRQDEFSGESTKPEASTSSDSVEKAADDAAQILEEKEAEASEPSQGAYNPETGEINWDCPCLGGMATGPCGEQFKAAFSCFVYSEAEPKGVDCVELFKVMQDCFREHPEIYGEVDTLGLVLMFYAEIDDDEAPPQEGTMEEKVEAAKEETAAPAAAP
What is the function of this protein?
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS).  Forms a redox cycle with ERV1 that involves a disulfide relay system.  Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.  The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
What are the official names of this protein?
Mitochondrial intermembrane space import and assembly protein 40, Mitochondrial import inner membrane translocase TIM40.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side.
Protein: SPF27_HUMAN
Sequence: MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF
What is the function of this protein?
Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961, PubMed:30705154).  Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.  May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.  The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
What are the official names of this protein?
Pre-mRNA-splicing factor SPF27, Breast carcinoma-amplified sequence 2, DNA amplified in mammary carcinoma 1 protein, Spliceosome-associated protein SPF 27.
What is the protein family that this protein belongs to?
Belongs to the SPF27 family.
Protein: RS21_AZOPC
Sequence: MIIVSLKEGENLEKALKKFKRKFERTGVSKELKRRQAFVKPSVLRRNQKIHAIYAQKFLQSGD
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RL21_PYUST
Sequence: MTNTKGYRRGSDMFSKKFRERGAIPLNKYLTVYKKGDIVDIKGDGSVQKVCPHKVYHGKTGRIFNVTQHAVGIIVNKQVRGRIIAKRINVRIEHIKHSKSRISFIQRVHENERKRKEAREKKIRVNLKRQPQQPRTGHFVRSSAEPELVEPIPYEF
What are the official names of this protein?
60S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.