PharMolix/UniProtQA huggingface dataset:
Protein: UBIC1_PSEPF
Sequence: MDTSHYWSSRPLSELTGSEHHWLFLPGALTPRLKAMGDYSIEVVEQSHGPLNPEEAQALNVSPNTIGWVREVVMKLDGEACVTARSLTSVPALNGDWADLNGYGRRPLAEILYTSEQTLREPFQCALLPPGAPLAALSYRYAPQAERLLARRSRFTRNGSALLVSECFLPAFWARVEYAQALKSA
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase 1, CL 1, CPL 1.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIT_PECAS
Sequence: MVSPHRLLKDYQQLLSLSQKILHLAISGQWDTLVEQEIVYVQSVEGLVNTPIPDEIDSVMRLHLRQILQEVMDNEAKVKQLLQKRMDELSSLMGQSLKQKSINATYSEFAGQRRLLDDPLPDETRS
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TYRP1_BOVIN
Sequence: MKSPTLLSLGYMFLVLLFFQQAWAQFPRECATIEALRNGVCCPDLSPLSGPGSDRCGLSSGRGRCEVVIADSRPHSHHYPHDGRDDREGWPTRSFNRTCHCNGNFSGHNCGTCRPGWGGAACDQRVLTVRRNLLDLSTEEKNRFVRALDMAKRTTHPQFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGAGQESFGEVDFSHEGPAFLTWHRYHLLQLERDMQEMLQDPSFSLPYWNFATGKNTCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCESLEDYDTLGTLCNSTEGGPIKRNPAGNVARPMVQRLPKPQDVAQCLEVGSYDTPPFYSNSTNSFRNTVEGYSHPTGRYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTYPLENAPIGHNRQYNMVPFWPPVTNIEMFVTAPDNLGYTYEVQWPSRSFSISEIVTIAVVAALSLVAVIFAGASCLIRARSNMDEANQPLLTDQYQHYIEEYEKIHNPNQSVV
What is the function of this protein?
Plays a role in melanin biosynthesis.  Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid.  May regulate or influence the type of melanin synthesized.  Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.
What are the official names of this protein?
5,6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, Tyrosinase-related protein 1, TRP-1, TRP1.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Melanosome membrane; Single-pass type I membrane protein. Melanosome. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Protein: Y660_RICCN
Sequence: MPSSYKLRKKIWKSVYLLITVGILYIGYILIKSGYINEKNDINVTKKSLKDNKNFDLKYNIILKDSIFEGVNKNLNAYKIKTERAIKESNNKYKLDIINAIYNVNQDQTLIINAKEGFLDEESSILDLKNDVKLFFDEIIFNTNDARIDLVNKNITGHSPAKLLYKNSSITSDSFNTKDENNIIIFKGNVSTIIDLSD
What are the official names of this protein?
Uncharacterized protein RC0660.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DHMA1_MYCTU
Sequence: MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPGDGPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSDKPTRIEDYTYLRHVEWVTSWFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARLVVANGFLPAAQGRTPLPFYVWRAFARYSPVLPAGRLVNFGTVHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPTSPDDPAVPANRAAWEALGRWDKPFLAIFGYRDPILGQADGPLIKHIPGAAGQPHARIKASHFIQEDSGTELAERMLSWQQAT
What is the function of this protein?
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
What are the official names of this protein?
Haloalkane dehalogenase 1.
What is the protein family that this protein belongs to?
Belongs to the haloalkane dehalogenase family. Type 1 subfamily.
Protein: RL32_CAMJE
Sequence: MAVPKRRVSKTRAAKRRTHYKVSLPMPIKDKDGSYKMPHRANPTTKEY
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: PUR9_VIBCM
Sequence: MNNARPIHRALLSVSDKTGIVEFAKALAERGVELLSTGGTARLLAEQGLTVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDAVMNTHGIQPIDMVVVNLYPFAQTVANPNCTLADAVENIDIGGPTMVRSAAKNHKDVAIVVNAHDYDRVIREMDANHNSLTLATRFDLAIAAFEHTAAYDGMIANYFGTLVPSYGDNKEGDEESKFPRTFNAQFIKKQDMRYGENSHQAAAFYVEANPQEASVATARQIQGKALSYNNIADTDAALECVKEFSEPACVIVKHANPCGVALGDDLLQAYNRAYQTDPTSAFGGIIAFNRELDGETARAIIERQFVEVIIAPKVSQAAIDIVAAKQNVRLLECGEWQGQTTGFDLKRVNGGLLVQDRDQGMVAQDDLQVVSTRQPSDAELKDALFCWKVAKYVKSNAIVYAKGDMTIGIGAGQMSRVYSAKIAGIKAADEGLEVAGSVMASDAFFPFRDGIDAAAEAGITCVIQPGGSMRDQEVIDAANEHGMAMIFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: Y1255_SYNY3
Sequence: MVDGRPMQITLNLPDRLNQIGEFDQNDWLREIAIALFEQEHISLARASKISSMEIMEFQKLLSDRGICIHYDVEELAQDIQHLQNRSWL
What are the official names of this protein?
UPF0175 protein ssl1255.
What is the protein family that this protein belongs to?
Belongs to the UPF0175 family.
Protein: DCTN6_XENTR
Sequence: MRQDVSLLSTSGSQKNPLGNVKIAPGAVVCVESEIKGDVTIGPRTVVHPKARIYAEAGPIIIGEGNLIEEQAFIRNSFPENIAPDSDVEPKTMIIGTNNVFEVGCYSQAMKMGDNNVIESKAFVGRNVILTSGCIIGACCQVDTCEVIPENTVIYGSDCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTTKNISTPMKS
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
What are the official names of this protein?
Dynactin subunit 6.
What is the protein family that this protein belongs to?
Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore.
Protein: DEOC_SALTY
Sequence: MTDLKASSLRALKLMDLTTLNDDDTNEKVIALCHQAKTPVGNTAAICIYPRFIPIARKTLKEQGTPDIRIATVTNFPHGNDDIDIALAETRAAIAYGADEVDVVFPYRALIAGNEQVGFDLVKACKDACAAANVLLKVIIETGELKEEALIRKASEISIKAGADFIKTSTGKVPVNATPESARIMMEVIRDMGVSKTVGFKPAGGVRTAEDAQKFLAIADELFGADWADSRHYRFGASSLLASLLKALGHGDGKSASSY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQB_ACICA
Sequence: MYIYVLGSAAGGGFPQWNCNCPNCHGVRTGTIQAKARTQSSIAVSENGTDWVLLNASPDIRQQLFEFKAAQPARKLRDTGIISVILMDSQLDHTTGLLTLREGCPMNVWCTEMVHQDLTNGFPVFNMLKHWNGGLQYHEINPKQAFKIDGFENLEFLPLIIKSAAPPYSPHRNNPHDGDNIALIIKDHKTQKQLFYAPGLGKIDDQIMQIMQSSDCVMIDGTLWTDDEMQQTGVGTKTGREMGHLYISGEGGSLSYLNKLSTPKKVLIHINNTNPILNENSSQFAELKANGVEVAYDGMQIEL
What is the function of this protein?
May be involved in the transport of PQQ or its precursor to the periplasm, in association with PQQ biosynthesis, but is not absolutely required for this synthesis.
What are the official names of this protein?
Coenzyme PQQ synthesis protein B, Coenzyme PQQ synthesis protein V, Pyrroloquinoline quinone biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the PqqB family.
Protein: NUOA_SALHS
Sequence: MSMSTSTEVIAHHWAFAIFLIVAIGLCCLMLVGGWFLGGRARARHKNVPFESGIDSVGTARLRLSAKFYLVAMFFVIFDVEALYLFAWSTSIRESGWVGFVEAAIFIFVLLAGLVYLARIGALDWTPARSRRERMNPETNSIANRQR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPF_SALHS
Sequence: MQFSKMHGLGNDFMVVDAVTQNVFFSPELIRRLSDRHLGVGFDQLLVVEPPYDPELDFHYRIFNADGSEVSQCGNGARCFARFVRLKGLTNKRDIRVSTANGRMVLSVTEDELVRVNMGEPNFEPAQVPFRANKAEKTYIMRAAEQTILCGVVSMGNPHCVIQVDNVDTAAVETLGPVLESHERFPERANIGFMQVVRREHIRLRVYERGAGETRACGSGACAAVAVGIQQGLLAEEVRVELPGGRLDIAWKGPGHPLYMTGPAAHIYDGFIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSF2B_HUMAN
Sequence: MGEAGAAEEACRHMGTKEEFVKVRKKDLERLTTEVMQIRDFLPRILNGEVLESFQKLKIVEKNLERKEQELEQLKMDCEHFKARLETVQADNIREKKEKLALRQQLNEAKQQLLQQAEYCTEMGAAACTLLWGVSSSEEVVKAILGGDKALKFFSITGQTMESFVKSLDGDVQELDSDESQFVFALAGIVTNVAAIACGREFLVNSSRVLLDTILQLLGDLKPGQCTKLKVLMLMSLYNVSINLKGLKYISESPGFIPLLWWLLSDPDAEVCLHVLRLVQSVVLEPEVFSKSASEFRSSLPLQRILAMSKSRNPRLQTAAQELLEDLRTLEHNV
What is the function of this protein?
Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair.  Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed:31242413).  Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity).  Required for proper recombinase recruitment in female meiosis (By similarity).  Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).  May be involved in modulating HSF2 activation in testis (PubMed:9651507).
What are the official names of this protein?
Heat shock factor 2-binding protein.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome. Note=Localizes on double- strand breaks (DSBs) in mitotic and meiotic chromosomes.
Protein: ATGT_PYRHO
Sequence: MSRGDKMLKFEIKARDGAGRIGKLEVNGKKIETPAIMPVVNPKQMVVEPKELEKMGFEIIITNSYIIYKDEELRRKALELGIHRMLDYNGIIEVDSGSFQLMKYGSIEVSNREIIEFQHRIGVDIGTFLDIPTPPDAPREQAVKELEITLSRAREAEEIKEIPMNATIQGSTYTDLRRYAARRLSSMNFEIHPIGGVVPLLESYRFRDVVDIVISSKMALRPDRPVHLFGAGHPIVFALAVAMGVDLFDSASYALYAKDDRYMTPEGTKRLDELDYFPCSCPVCSKYTPQELREMPKEERTRLLALHNLWVIKEEIKRVKQAIKEGELWRLVDERARSHPKLYSAYKRLLEHYTFLEEFEPITKKSALFKISNESLRWPVVRRAKERAKSINERFGELVEHPIFGRVSRYLSLTYPFAQSEAEDDFKIEKPTKEDAIKYVMAIAEYQFGEGASRAFDDAKVELSKTGMPRQVKVNGKRLATVRADDGLLTLGIEGAKRLHRVLPYPRMRVVVNKEAEPFARKGKDVFAKFVIFADPGIRPYDEVLVVNENDELLATGQALLSGREMIVFQYGRAVKVRKGVE
What is the function of this protein?
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
What are the official names of this protein?
tRNA-guanine(15) transglycosylase, 7-cyano-7-deazaguanine tRNA-ribosyltransferase, Archaeal tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the archaeosine tRNA-ribosyltransferase family.
Protein: CBF5_ARATH
Sequence: MAEVDISHSKKKKQDKTENDAADTGDYMIKPQSFTPAIDTSQWPILLKNYDRLNVRTGHYTPISAGHSPLKRPLQEYIRYGVINLDKPANPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGNLIVCIDRATRLVKSQQGAGKEYVCVARLHSAVPDVAKVARALESLTGAVFQRPPLISAVKRQLRIRTIYESKLLEYDADRHLVVFWVSCEAGTYIRTMCVHLGLLLGVGGHMQELRRVRSGILGENNNMVTMHDVMDAQFVYDNSRDESYLRRVIMPLEMILTSYKRLVVKDSAVNAICYGAKLMIPGLLRFENDIDVGTEVVLMTTKGEAIAVGIAEMTTSVMATCDHGVVAKIKRVVMDRDTYPRKWGLGPRASMKKKLIADGKLDKHGKPNEKTPVEWSRNVVLPTGGDAIIAGAAAAPEEIKADAENGEAGEARKRKHDDSSDSPAPVTTKKSKTKEVEGEEAEEKVKSSKKKKKKDKEEEKEEEAGSEKKEKKKKKDKKEEVIEEVASPKSEKKKKKKSKDTEAAVDAEDESAAEKSEKKKKKKDKKKKNKDSEDDEE
What is the function of this protein?
Plays a central role in ribosomal RNA processing.  Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit 4, CBF5 homolog, Dyskerin, Nopp-140-associated protein of 57 kDa homolog, AtNAP57, Nucleolar protein NAP57 homolog.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MSRQ_YERP3
Sequence: MRLSLRHITWLKIAIWLAATLPLLWLVLSINLGGLSADPAKDIQHFTGRMALKLLLATLLVSPLARYSKQPLLLRCRRLLGLWCFAWGTLHLLSYSILELGLSNIGLLGHELINRPYLTLGIISWLVLLALALTSTRWAQRKMGARWQKLHNWVYVVAILAPIHYLWSVKTLSPWPIIYAVMAALLLLLRYKLLLPRYKKFRQ
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HUTI_THEVO
Sequence: MKITNIGAIVTPVGNSYHSGDKQSELDFIENATIYIENGKIAKITREHSSDAGDLDAEGSIVIPGLVDSHTHIIFGGNRSQEFYQRASGYTYSEILRSGNGIYKTVRDTANSSADEIFTQSMKRIADAVSHGTTTIELKTGYGLYEKEERKLLDVARKISNSGLVSTVLTYLMHVLPEGESEEAYEKYSEKILSSFRNYISFADVFCDEGAFSPNAAKAFLKFADNLGLGLKIHANEINNIGCVKACSGLNVKSFDHMIHANAEDVETIRSIGSAITLLPLTVFALDESYPDARVFIDSGVPVIIASDISPLNYNANLIFAMHLAVKYSSMKPEEALTATTINAASSLGLGEKKGTVEEGKDADIVIIDVDDYTEIPYEYGINTVKKVFHNGSLVFDRTKQFKL
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_BURO1
Sequence: MSVSPVSIVSTPVAVSASPAGAPDQPVQPVTVRWRGREAYEASFDAMRAFTDTRTADTGDEIWVVEHPPVYTLGQAGDPAHLLVADSGVPLVKVDRGGQITYHGPGQIVVYLLLDLRRRKLMVRALVTKIEEAVIETLAAYNLASVRKAGAPGIYVASGVHEGAKIAALGLKIRNGCSYHGLSLNVKMDLRPFLAINPCGYAGLETVDMASLEVAADWNDVAHTLVGRLIANLDGASAAADKPHALEQSND
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
Protein: CYB_SORTE
Sequence: MTHLRKTHPLMKIINSSFIDLPTPSNISSWWNFGSLLGVCLVVQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGLYYGSYMFLETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSDLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAGVHLLFLHETGSNNPSGLSSDADKIPFHPYYTIKDILGVLLLILALTSLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLAVIPFLHTSKQRSMMFRPFSQCLFWILVADLLTLTWIGGQPVEHPFIIIGQLASILYFLLILVLMPITSLFENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL2_MARN8
Sequence: MPIVKTKPTSAGRRHVVKLYNPDLHKGRPYEPLVETKSKSGGRNNVGRITTRHIGGGHKQHYRVIDFKRTKDGIPAVIERLEYDPNRSAHIALVKYADGERRYIIAPKGMKAGDPVRSGVDAPIKVGSTLPLRNIPVGSVIHCVELKPGKGAQLARSAGASVQLVAREGAYATIRLRSGEMRKVLVDCRATLGEVSNSEHSLKQLGKAGASRWRGKRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVTPWGVPTKGHKTRKNKRTDKMIVRRRSAK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DEF_CHLSY
Sequence: MAIRRILRIDDAEDRKILKMQCRPVKLPDRNLKQLVADMFETMRAAHGVGLAAPQIGIPIQLCIIEIPAEYEERADGSVVEVAPAEPYVLINPRIVKMSGEEVMRDEGCLSLPGWYGMVPRQTWVTVEFQDLNGKHHRLRRAGDLLGWAIQHEVDHLNGILFTERIRDLSTLRDITKERDAQPVDQAP
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RS15_CHLPN
Sequence: MSLDKGTKEEITKKFQLHEKDTGSADVQIAILTEHIAELKEHLKRSPKDQNSRLALLKLVGQRRKLLEYLNSTDTERYKNLITRLNLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: AN32B_CHICK
Sequence: MEMKKRLTLELRNKKPGEVKELVLDNCRSDDGKIVGLSSDFENLEFLSMINVNLLSISNLPKLNKLRKLELSDNRISGGLEVLAERTPNLTHLNLSGNKIKDINTLEPLKKLPNLHSLDLFNCEVTMLINYRESVFTLLPQLTYLDGFDADEQEAPDSDPEADGDGLEDEYENGEGEEEEDDDEEDDLDEEVIDEEDDEDDDLEGEEEEDGVDDEEEDEEEDGEDEEDDEADDDLPRGEKRKRNLEDEGEEDPEDEEDDEDD
What is the function of this protein?
Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription.  Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle.  As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis.  Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes.  Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1.
What are the official names of this protein?
Acidic leucine-rich nuclear phosphoprotein 32 family member B.
What is the protein family that this protein belongs to?
Belongs to the ANP32 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDM34_UNCRE
Sequence: MAFNFNWSPLMADAGFYTRAQDLLTAALNKSPKPPIIVDDIAVTELNLGSIPPELEILEVGDLAEDRFRGIFKMSYSGDAFLTLKTRVQANPLNTFLITRPAYASPKPLAAASGLTIPLQITLSNFRLSGFVVLVFSKQKGITVVFRNDPLESLKVSSTFDSIPSVRDYLQREIEGQLRILFMDELPAIIHRLSLRLWVPEYRGLEAGIPETAIPSSLGPGEDTLLNPPKDPVDASGNLLSSAEIASLSLDSGVEMHSLFSQKNLLRLAALTNSQRTLSLFTPSIREVMFRARTGLADQGEGLGSGLMSPGSPALSRTHSHISSPLSSFQDSSSVLSLQQRSTTAASSFSGYGLSLGAGRHTKARPTKKRKKRVVDLRKQSKPTDPEITSADGGYTETSTASTTFSSSTVPEEVNDDPVTPPLSPETTIRFPNRQHRFSTSEGKVIARAPAQQLTYSEPSHSALHTQTANPVPAVPLHAEGAAVPPQQALVFGDEHLGSREKSMEAQSSHGPNPGLSITDAAPNSSILEQAWMMKMANEIARRIQEQNSLVNNNYPGPWEQTRARTPPPAYGQ
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: PCGF1_RAT
Sequence: MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIRDFYQSRGLDRVSQPSGEEPALRGLGLPFTSFDHYYRYDEQLSLCLERLSSGKDKNKNVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQLWLSRWFGKPSPLLLQYSVKEKRR
What is the function of this protein?
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A.  Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway.  Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element).  Promotes cell cycle progression and enhances cell proliferation as well.  May have a positive role in tumor cell growth by down-regulating CDKN1A.  Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.  Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.  Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells.
What are the official names of this protein?
Polycomb group RING finger protein 1, Nervous system Polycomb-1, NSPc1.
What are the subcellular locations of this protein?
Nucleus.