PharMolix/UniProtQA huggingface dataset:
Protein: IKKA_CHICK
Sequence: MERGAERGPPPAPGGVALRGQPAGGCGPWEMRDRLGTGGFGNVCLYQHQDTGARVAIKSCRLELSVKNKDRWCHEIDIMKKLNHPNVVRACEVPEEMNFLVNDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIQYLHENRIIHRDLKPENIVLQDEGGKIIHKIIDLGYAKDLDQGSLCTSFVGTLQYLAPELFENKSYSVTVDYWSFGTMVFECIAGFRPFLHNLQPFTWHEKIKKKDPKHIFASEEMNGEVRFSTHLPQPHSICSLIVEPMESWLQLMLNWDPEQRGGGLDPETNSPKCFLLMDHILNLKIVHILNMTSAKIVSFLLHPEESLHFLQNRIESETGISTGNQELLLETGICLDPRKPASQCVIDGVRGWDSYMVYLFDKSKTVYDGPFASRSLSECVNYIVQDSKIQLPIPQLRKVWAEAVHYVIGLKEDYSRLFQGQRAAMLSLLRYNANLIKMKNNMVSASQQLKAKLEFFHQSIRLDLERYSDQMAYGISSEKMLKAWKEMEEKASHCAQAEDIGYLDEQIMALHTEIVELQKSPYARRQGEVMESLEQRAIDLYKQLKTRPPDHAYSDSTDMVKIIVQTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKIEVALNNIKEADNSEMQMQGKRQREIWHLLKIACTQSSSRSLVSSSLEGTASTPAATWVPQSSSEYAPHPLSSMATPGDGENFVDVIEENLNYLDRFSSMLQEAREEQNNSLTNFDWSWLK
What is the function of this protein?
Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor.  Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
What are the official names of this protein?
Inhibitor of nuclear factor kappa-B kinase subunit alpha, I kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, Conserved helix-loop-helix ubiquitous kinase, Nuclear factor NF-kappa-B inhibitor kinase alpha, NFKBIKA.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
Protein: STKP_STRP2
Sequence: MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVAFAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQNPLPSVIAENSSVPQALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYNRRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIKNPSQAVTEETYQPQAPKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANFEIGEEKTEASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSDVIAELKEKKVPDNLIKIEEEESNESEAGTVLKQSLPEGTTYDLSKATQIVLTVAKKATTIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAGTTYDVSKPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSVEGMVVEQSPRAGEKVDLNKTRVKISIYKPKTTSATP
What is the function of this protein?
Protein kinase involved in signal transduction pathways that regulate various cellular processes.  Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates.  Plays a crucial role in the regulation of cell shape and cell division of S. pneumoniae through control of at least DivIVA activity.  Is involved in competence triggering, and is required for the expression of the central competence operon comCDE.  StkP also plays an important role for bacterial survival in vivo.  Identified target substrates that are specifically phosphorylated by StkP in vivo, mainly on threonine residues, are DivIVA, GlmM, PpaC, MapZ, KhpB (also called EloR/Jag, shown in strains R6 and Rx1) and StkP itself.  Autophosphorylated StkP is a substrate for the cotranscribed protein phosphatase PhpP (shown in the avirulent strain Rx / Cp1015); PhpP and StkP appear to constitute a functional signaling couple in vivo.
What are the official names of this protein?
Serine/threonine-protein kinase StkP, Ser/Thr-protein kinase StkP, Eukaryotic-type Ser/Thr protein kinase, ESTPK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Localizes to the midcell division sites, colocalizes with PBP2b.
Protein: FALX7_LITFA
Sequence: MASLKKSFFLVLFLGLVSLSMCEEKKRENEDDAEDGNHEEESEEKRGLVDFAKHVIGIASKLGKRSEEKRYHPFGKRSEEKRYFPIPFGKRSEEKRYFPIPIGKRSEEKRYFPIPIGKRSEEKRYFPIPIGK
What is the function of this protein?
Fallaxidin-1. 3 shows no antibacterial activity against Gram-positive or Gram-negative bacteria.  Does not inhibit the formation of NO by neuronal nitric oxide synthase.  Has no effect on splenocyte proliferation or smooth muscle contraction.
What are the official names of this protein?
Preprofallaxidin-7.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RIMS3_MOUSE
Sequence: MFNGEPGPASAGASRNVVRSSSISGEICGSQQAGGGAGTTTAKKRRSSLGAKMVAIVGLTQWSKSTLQLPQPEGATKKLRSNIRRSTETGIAVEMRSRVTRQGSRESTDGSTNSNSSEGTFIFPTRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDVHIAIMDRSGQLEVEVIEARGLTPKPGSKSLPATYIKAYLLENGACVAKKKTKVAKKTCDPLYQQALLFDEGPQGKVLQVIVWGDYGRMDHKCFMGMAQIMLDELDLSAAVTGWYKLFPTSSVADSTLGSLTRRLSQSSLESATSPSCS
What is the function of this protein?
Regulates synaptic membrane exocytosis.
What are the official names of this protein?
Regulating synaptic membrane exocytosis protein 3, Nim3, RIM3 gamma, Rab-3-interacting molecule 3, RIM 3.
What are the subcellular locations of this protein?
Synapse.
Protein: NUOD_MYCA1
Sequence: MSTTTESTHDGAGETLVVAGGQDWDKVVEAARSADPGERIVVNMGPQHPSTHGVLRLILEIEGETVTEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGITDQIPERVNVIRVMMMELNRISSHLVALATGGMELGAMTPMFVGFRGREIVLTLFESITGLRMNSAYIRPGGVAQDLPPNAKTEIAQALDQLRQPLREMGDLLNENAIWKARTQDIGYLDLTGCMALGITGPILRATGLPHDLRKSEPYCGYENYEFDVITADTCDAYGRYMIRVKEMWESIKIVEQCLDKLQPGPIMVENGKIAWPADLKVGPDGLGNSPEHIAKIMGGSMEALIHHFKLVTEGIRVPPGQVYTAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQSVAAMCEGGMVADLITAVASIDPVMGGVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PSB_SACEN
Sequence: MSPMESSSTRFPGQALPAAYLTPGSSSFTDFLRVAAPELMPGSRPVPDGAVEAPHGTTIVALTFRGGVLLAGDRRATMGNLIAQRDMEKLYVTDDYSAVGIAGTAGIALEMVRLYAIELEHYEKLEGVSLSLDGKANKLATMLRGNLQGAMAGLAVLPLFAGFDVDADDPDRAGRIVSYDITGGRYNELGGYYAVGSGSLFAKSALKKRFDPDADVDTAVRAAVEALYDAADDDTATGGPDLSRRIYPSIITITGTDGATRVPEERAAEIATEVVNGRMQNPGG
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PrcB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_PSEFS
Sequence: MQYNLTRIDPDAPNDQYPIGERETVSDPLEDQVHKNIYMGKLEDVLSGAVNWGRKNSLWPYNFGLSCCYVEMTTAFTAPHDIARFGAEVIRASPRQADFMVIAGTCFIKMAPIIQRLYEQMLEPKWVISMGSCANSGGMYDIYSVVQGVDKFLPVDVYVPGCPPRPEAFLQGLMLLQESIGKERRPLSWVVGDQGVYRAEMPSQKEQRREQRIAVTNLRSPDEV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: UBIA_AZOSB
Sequence: MTLSDRLPLYGRLMRLDKPIGSLLLLWPTLWALWLAADGKPPLHVLVIFTIGTVLMRSAGCVINDYADRDFDGHVERTRNRPLATRAVSTREALALAAGLSALSFVLILPLDPLVIWLSFPALFLAASYPFTKRFFAIPQAYLGIAFGFGIPMGFAAVQGEVPPIAWVMLLANIFWAVAYDTEYAMVDRPDDLKIGIKTSAITFGRFDVAAVMLCYAVALGLLGWVGAQAGRGALYFAGLAVAAGMALYHYTLIRHRERAPCFKAFRHNNWLGAAVFAGLALDYLIG
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ERA_BRADU
Sequence: MTVEASGEAPAATRCGFVALIGAPNVGKSTLVNALVGAKVTIVSRKVQTTRALIRGIVIENNAQIILVDTPGIFSPKRRLDRAMVSTAWSGAHDADLVCVLLDAKTGIDEEAEAILAKAASVNHDKILVINKVDLVQREKLLALAQAANERMPFAKTFMIAAISGDGVDDLRSTLAEMVPPGPFLYPEDQMSDAPMRHLAAEITREKIYRKLHQELPYQSTVETDKWEERKDKSVRIEQTIFVERESQRKIVLGKGGATIKSIGADSRKEISEILGVPVHLFLFVKVRENWGDDPDRYREMGLEFPKE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: RIMK_ERYLH
Sequence: MKIAMLARNPNLYSHKRLVEAAEKRGHSLDILNTTRCTVNIASHRPTISYNGETIKGYDAVIPRIGASITNYGLAVLRQFEMAGVWPLNESVAIGRSRDKLRSMQILAKYGLGLPLTAYANDPKQAEEIIKAVNGPPVVIKLLEGTQGIGVVLAETMSSAKSVIEAFRGANVNILVQEFIKEAGGTDIRALVVGGKVVAAMKRTGAADDFRSNLHRGGSAQLIKITPEERSTAVRAAKHMGLNVCGVDMLRSNHGPVIMEVNSSPGLEGIEKATEKDIAGQIIDYIAANAKAGKTKTKGQG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: MTUS1_BOVIN
Sequence: MLLSPKFSLSTIHVRLTAKGLLRNLRLPSGFRKSTVIFHTVEKGRQKSPRSLCIQTQTSPDVLSSEKALELAQYKSKCTKQSGIILQLKQLLSLGNTKFEALTVVAQHLLSEREEALKQNKTLSQELVNLRGELVTVSTTCEKLEKARNELQIAYEGFVQKLNQQHQTDLTELENRLKEFYTGECEKLQNIYIEEAEKYKTQLQEQFDNLNATHETSKLKIEASHSEKIELLKKAYENSLSEIKKSHEMEKKSLEDLLYEKQESLEKQISDLKSENDTLNEKLKSEEQKRISREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDVKLMKMEKLVDSNTALVDRLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGNLCSPKRSPTSPAAPFQSPRNSGSFPSPSISHPDDLPGNQRQTEGISAGLTLPATAHHPP
What is the function of this protein?
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation.  May be required for AGTR2 cell surface expression.  Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity).
What are the official names of this protein?
Microtubule-associated tumor suppressor 1 homolog, Mitochondrial tumor suppressor 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the MTUS1 family.
What are the subcellular locations of this protein?
Mitochondrion. Golgi apparatus. Cell membrane. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II.
Protein: SYGA_STRPD
Sequence: MSKKLTFQEIILTLQQYWNDQGCMLMQAYDNEKGAGTMSPYTFLRAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLASLEKLGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATSPVTAEVTYGLERLASYIQEVDSVYDIEWAPGVKYGEIFLQPEYEHSKYSFEISDQDMLLENFEKFEKEASRALEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYIARIRNLARVVAKTFVAERKKLGFPLLDEATRAILLAEDDE
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAAI_ECODH
Sequence: MKSVFTISASLAISLMLCCTAQANDHKLLGAIAMPRNETNDLALKLPVCRIVKRIQLSADHGDLQLSGASVYFKAARSASQSLNIPSEIKEGQTTDWININSDNDNKRCVSKITFSGHTVNSSDMATLKIIGDD
What are the official names of this protein?
UPF0412 protein YaaI.
What is the protein family that this protein belongs to?
Belongs to the UPF0412 family.
Protein: CYB5_ALOSE
Sequence: SDEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATEDFEDVGHSTDARELSKTYIIGELHPDDRPK
What is the function of this protein?
Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
What are the official names of this protein?
Cytochrome b5.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b5 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: GPDA_SHEB9
Sequence: MKNSADITVLGAGSYGSALAISLASNGHKTLLWGHDPVHMQTLAQDKCNQAFLPGIAFPDCLQIEADLAKALAASNNVLVVVPSHVFGTVLEQAKPLLRSDARIVWATKGLEPETGRLLQDVARDVLGEQYPLAVLSGPTFAKELAMGLPTAISVAGTCPTFTNDLVELLHSPKRLRVYANDDFTGLQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLVELTRLGEALGANAATFMGMAGLGDLVLTCTDNQSRNRRFGLALGKGCDVMTAQAEIGQVVEGYRNTKEVFTLAKRLGVEMPITEQIYQVLYQGKSPVDAAKELLSREKKSETPAQ
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FB201_ARATH
Sequence: MVPLPWELEEDILSRLAAQSLVRFRSVCKRWNYLFDEKSFIKNHFARACPQFIFMTDSNIYSIEIIGLDGVDPTIKLRVLDSSGIPYRDWKFAYITITACDGFLFCNSWASPKGTAFWNPWLKQVKWIEYEDKGFNVCGLGYDNTRDGKVYKILGYLMCRPEDGSSYVYHQRVAIYDCASHAFKFIEISNKDWFLTDVTRFSVSLNGNLYWLSPIPNTDDFLIQCFDFSREICKPFCLLPCRKFDAFDLLVSFQGR
What are the official names of this protein?
Putative F-box protein At3g51171.
Protein: PRIB_ECO27
Sequence: MTNRLVLSGTVCRTPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIVSGHENQAITHSITVGSRITVQGFISCHKAKNGLSKMVLHAEQIELIDSGD
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).  During primosome assembly it facilitates the complex formation between PriA and DnaT.
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: RPOZ_BORA1
Sequence: MARITVEDCLNQIPNRFKLTLAATYRARELAQGHAPRLDSKDKPTVTALREIASGLTGLEMLRKVPT
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: B3GLT_MOUSE
Sequence: MRPPALLALFSCSAAFALMSEEIKEKVTPSQDLRQSSLPGRHDIDLKEIVFVIQSQSNSFHAKRAEQLKKNILKQAANLTQDLPRVLLLHQLAKQEGAWTILPLLPHFSVTYSKNSAWIFFCEEETRLQIPRLLDTLRRYDPSKEWFLGKALYDEESTIIHHYAFSENPTVFKYPDFAAGWALSIPLVNKLAKRLKSEALKSDFTIDLKHEIALYIWDKGGGPALTPVPEFCTEDVDPRCVTTFHSFLPLCGVPVKKEEIFVAVKTCKKFHADRIPIVKKTWAAQASLIEYYSDYAETAIPTVDLGIPNTDRGHCGKTFAILEKFLNHSHNKISWLVIVDDDTLISISRLRHLLSCYDSSDPVFLGERYGYGLGTGGYSYVTGGGGMVFSREAIRRLLVSSCRCYSNDAPDDMVLGMCFSGLGVPVTHSPLFHQARPVDYPKDYLAHQIPVSFHKHWHIDPVKVYLTWLAPSEEDQATQETQKDPREEL
What is the function of this protein?
O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage.  Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan (By similarity).
What are the official names of this protein?
Beta-1,3-glucosyltransferase, Beta3Glc-T, Beta 3-glucosyltransferase, Beta-3-glycosyltransferase-like.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: RS17_CLOB6
Sequence: MERSNRKTRIGRVVSNKMDKTIVVAVETKVRHPLYGKIMNRTTKFKAHDENNTANINDKVLIMETRPLSKQKRWRLVEVVEKAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: LEXA_CITBB
Sequence: MEQLTARQTEVLQIITRHLETCGYPPTLREIAAQLGISGTLGVMKHLEALEKKGYLRRQEGSTRGITLCNQSQAASLPIVGVVRAGLLHPAIQDIEGHFAIDRSQLASGGAFFLRVKGDSMVHAHIVEGDLALVRPQPHASNRDIVVAMVDGEATLKRFYREADRIRLQPENPNYEPIIIEKGEQEVSIVGKVVGIYRQME
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: ILVC_MYCVP
Sequence: MAVEMFYDADADLSIIQGRKVAVIGYGSQGHAHSLSLRDSGVQVKVGLKEGSKSREKVTEQGLEVDTPAEVAKWADVIMLLAPDTAQAEIFTNDIEPNLEDGNALFFGHGLNIHFGLIKPPANVTIGMVAPKGPGHLVRRQFVDGKGVPCLIAIDQDPKGEGQALALSYAAAIGGARAGVIKTTFKEETETDLFGEQAVLCGGTEELVKTGFEVMVEAGYAPEMAYFEVLHELKLIVDLMYEGGIARMNYSVSDTAEFGGYLSGPRVIDADTKKRMQDILKDIQDGTFVKRLVANVEGGNKELEALRKKNAEHPIEVTGKKLRDLMSWVDRPITETA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: YIHR_ECOLI
Sequence: MSLIKVPCMQITNMHCSGQTVSLAAGDYHATIVTVGAGLAELTFQGCHLVIPHKPEEMPLAHLGKVLIPWPNRIANGCYRYQGQEYQLPINEHSSKAAIHGLLAWRDWQISELTATSVTLTAFLPPSYGYPFMLASQVVYSLNAHTGLSVEIASQNIGTVAAPYGVGIHPYLTCNLTSVDEYLFQLPANQVYAVDEHANPTTLHHVDELDLNFTQAKKIAATKIDHTFKTANDLWEMTITHPQQALSVSLCSDQLWVQVYSGEKLQRQGLAVEPMSCPPNAFNSGIDLLLLESGKPHRLFFNIYGQRK
What are the official names of this protein?
Uncharacterized protein YihR.
Protein: CLPX_PECAS
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRRHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDSSNGIELGKSNILLIGPTGSGKTLLAETLARFLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTIAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVIEQRTDTGRGIGFNATVKGSAEKATEGELLSHVEPGDLIKFGLIPEFIGRLPVVATLRELSEDALIQILREPKNALTKQYQALFNLEGVELEFRDEALTAIAKKAMVRKTGARGLRSIVEAALLETMYDLPSLESVDKVVIDESVIAGHSEPLLIYGKHETQQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: SARA_STAAC
Sequence: MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
What is the function of this protein?
Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner.
What are the official names of this protein?
Transcriptional regulator SarA, Staphylococcal accessory regulator A.
What is the protein family that this protein belongs to?
Belongs to the SarA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERO1A_PIG
Sequence: MGHRWGFLIVFLGAVGLLGSGYGRQQPSETAAQRCFCQVSGYLDDCTCDVETIDRFNNYRLFPRLQKLLESDYFRYYKVNLKRPCPFWNDINQCGRRDCAVKPCQSDEIPDGIKSASYKYSEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEADDIQSPDAEYVDLLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPLNPLASGQGKSEENTFYSWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQDTWLEKKWGHNITEFQQRFDGILTEGEGPRRLKNLYFLYLIELRALSKVVPFFERPDFQLFTGNKVQDAENKMLLLDILHEIKSFPLHFDENSFFAGDKKEANKLKEDFRLHFRNISRIMDCVGCLKCRLWGKLQTQGLGTALKILFSEKLIANMPESGPSYEFHLTRQEIVSLFNAFGRISTSVKELENFRNLLQNIH
What is the function of this protein?
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum.  Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation.  Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell.  Required for the proper folding of immunoglobulins.  Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
What are the official names of this protein?
ERO1-like protein alpha, ERO1-L, ERO1-L-alpha, Endoplasmic reticulum oxidoreductase alpha, Endoplasmic reticulum oxidoreductin-1-like protein, Oxidoreductin-1-L-alpha.
What is the protein family that this protein belongs to?
Belongs to the EROs family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Golgi apparatus lumen. Secreted. Cell projection, dendrite. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum (By similarity). In neurons, it localizes to dendrites (By similarity).