PharMolix/UniProtQA huggingface dataset:
Protein: GHRB_YERPN
Sequence: MKPSIVLYKSIPTDLHQRLAQHFTVNSFDGLTPDNQPELLAALQQAEGLIGSGGKIDQDFLQLAPNLRAASTISVGYDNFDVEALSQRGIALMHTPTVLTETVADTMMALMLSTARRVVELAERVKAGEWQESIGDDWFGVDVHHKTIGILGMGRIGMALAQRAHFGFSMPVLYTSRRPHEAAEQRFGARHCSLDTLLAEADFLCITLPMTEQTYHMIGREQLAKMKSSAILINAGRGPVVDEQTLIAALQDGTIHAAGLDVFEQEPLPVDSPLLTLRNVVAVPHIGSATHETRYNMAACAVDNLINALTGTVKENCVNPQVLITH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_ENTFA
Sequence: MENRYAIILAAGKGTRMKSKLYKVLHPVAGKPMVEHILDQVEQTEPTEIVTIVGHGAEMIKSHLGERSQYALQAEQLGTGHAVMQAQELLGGKQGTTLVITGDTPLLTAETLKNLFDYHQGKNASATILTAHAEDPTGYGRIIRDHVGIVERIVEQKDASEEEARVQEINTGTFCFDNESLFEALAKTDTNNTQGEYYLTDIIEILKKEGKAVAAYQMADFDEAMGVNDRVALSTANKIMHRRLNEMHMRNGVTFIDPDTTYIDEGVVIGSDTVIEAGVTIKGKTVIGEDCLIGAHSEIVDSHIGNQVVVKQSVIEESVVHEGADVGPYAHLRPKADVGANVHIGNFVEVKNATIDEGTKVGHLTYVGDATLGKDINVGCGVVFVNYDGKNKHQTIVGDHAFIGSATNIVAPVTIGDHAVTAAGSTITEDVPSEDLAIARARQVNKEGYAKKLPYMKD
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_FRATO
Sequence: MKDSIKAKLQSLIERHEEVSALLSEAGIISDQNKFRDLSKEYSHLEPIVKAFKEYTQALEDKQAAYEMLNEKDAELVEMAKEELKLANEAIEKLESELQIFLLPRDPNDDANVFLEIRAGTGGDEASIFSGDLFKMYSKYAEQRGWKIEVISASEGEHGGYKEIISRIYGDGVYSQLKFESGAHRVQRVPATESQGRIHTSACTVAVMPEADEVEGIDINPADIKVDTFRASGAGGQHVNKTDSAIRITHIPTGVVVECQDQRSQHKNRAAAMSMLKSKLLQAEIDKQQKEQSDTRKSLVGSGDRSERIRTYNYPQGRVTDHRINLTLYKLDEVMEGSLDSIIQPLVLEHQADLLATMSDE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_LACPL
Sequence: MPRKGAPAKREVLADPMYNSKLVTRLINHLMLDGKRGTASTILYDAFDQIKEQTGNDPLEVFEEAMKNVMPVLEVKARRVGGSNYQVPIEVRPDRKTTLGLRWIVQYARSRGEHTMSDRLAREIMDAANNTGASVKKREDTHRMAEANRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: COAD_ECOUT
Sequence: MQKRAIYPGTFDPITNGHIDIVTRATQMFDHVILAIAASPSKKPMFTLEERVELAQQATAHLGNVEVVGFSDLMANFARNQHATVLIRGLRAVADFEYEMQLAHMNRHLMPELESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPENVHQALMAKLA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNB_YERPY
Sequence: MQSFLPFSRPAIGSEEINAVANVLGSGWITTGPQNHQLETDFCQIFGCKHAIAVCSATAGMHITLLALGIGPGDEVITPSQTWVSTINMIVLLGAEPVMVDVDRDTLMVNAAAIEAAITPNTKAIIPVHYAGAPCDLDALRQISQRHGIPLIEDAAHAVGTRYRDQWIGEQGTAIFSFHAIKNITCAEGGLVATDDDELAARVRRLKFHGLGVDAFDRQIQGRSPQAEVVEPGYKYNLSDIHAAIAVVQLRRLPEINARRQALVASYHKALAHLPLQPLALPHYSHQHAWHLFMVRVDEERCGISRDQLMACLKDMGIGSGLHFRAVHSQKYYRERYPHLCLPNTEWNSARLCTLPLFPDMLDSDIERVANALTTIIGSHRVTK
What is the function of this protein?
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase, UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase, UDP-Ara4O aminotransferase, UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
Protein: KHSE_BURCJ
Sequence: MAVFTAVSDSDLAQWMRHYELGDVLAFRGIPSGIENSNFFLTTTRGEYVLTIFEKLTAQQLPFYLDLMRHLAAHGVPVPDPIPRDDGALFGELHGKPAAIVTKLDGAAELAPGVEHCIEVGQMLARLHLAGRDYPRSQPNLRSLPWWQENVPAIVPFITDAQRTLLEGELAHQAGFFASDDYAALPAGPCHCDLFRDNVLFAHAAPGTGHDVRLGGFFDFYFAGCDKWLFDVAVTVNDWCVDLATGVLDVARADALLRAYQTVRPFTAEERRHWSDMLRAGAYRFWVSRLYDFYLPRAAEMLKPHDPGHFERILRERIAHTPALPEIQTACN
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: PDE4D_RAT
Sequence: MEAEGSSVPARAGSHEGSDSSGGAALKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQLQPPPPPPLPPPPPPPGATRGRYASSGASRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMAIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQEDGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPQTGVADDCCPDT
What is the function of this protein?
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
What are the official names of this protein?
cAMP-specific 3',5'-cyclic phosphodiesterase 4D, DPDE3.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
What are the subcellular locations of this protein?
Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome. Colocalized with SHANK2 to the apical membrane of colonic crypt cells.
Protein: ACCA_CAMJ8
Sequence: MASYLDFEKNIQQIDEDIINAQIKGDTEAVSILKKNLEKEISKTYKNLSDFQRLQLARHPDRPYALDYIELILNDAHEIHGDRAFRDDPAIVCFMGYLGEKKIIVIGEQKGRGTKDKIARNFGMPHPEGYRKALRVARLAEKFQIPILFLIDTPGAYPGIGAEERGQSEAIARNLYELSDLKIPTIAIVIGEGGSGGALAIGVADRLAMMKNSVFSVISPEGCAAILWNDPAKSEAATKAMKVTADDLKSQGLIDDVIDEPTNGAHRNKEAAAVAIADYVKKSLNELENIDVRELSANRMQKILKLGAYQEA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTGIS_MOUSE
Sequence: MSWAALLGLLAVLLLLLLLLSRRRARRPGEPPLDLGSIPWLGHALEFGRDAASFLTRMKEKHGDIFTVLVGGRYVTVLLDPHSYDTVVWELRTRLDFHPYAIFLMERIFDLQLPNFNPSEEKARMKPTLMHRDLQALTEAMYTNLRTVLLGDSTEAGSGWQETGLLEFSYNALLSAGYLTLYGVEASPRTHESQAQDRVHSADVFHTFRQLDLLLPKLARGSLSAGDKDHACSVKNRLWKLLSPARLASRADRSSWLESYLRHLEEMGVSEEMQARALVLQLWATQGNMGPTAFWLLLFLLKNPEALAAVRAELKHTVWQAEQPVSQMTTLPQKILDSMPVLDSVLNETLRLTAAPFITREVMADLALPMADGREFSLRRGDRLLLFPFLSPQKDPEIYTEPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNQCLGKSYAINSIKQFVVLLLTHFDLELGSEDTEVPEFDLSRYGFGLMQPEEDVPIRYRARL
What is the function of this protein?
Catalyzes the biosynthesis and metabolism of eicosanoids.  Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation.  Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE).
What are the official names of this protein?
Prostacyclin synthase, Hydroperoxy icosatetraenoate dehydratase, Prostaglandin I2 synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: AOS2_SOLLC
Sequence: MALTLSFSLPLPSLHQKIPSKYSTFRPIIVSLSDKSTIEITQPIKLSTRTIPGDYGLPGIGPWKDRLDYFYNQGKNDFFESRIAKYKSTIFRTNMPPGPFITSNPKVIVLLDGKSFPVLFDASKVEKKDLFTGTFVPSTELTGGYRILSYLDPSEPNHEKLKKLMFFLLSSRRDHVIPEFHETYTELFETLDKEMEEKGTVGFNSGSDQAAFNFLARSLFGVNPVETKLGTDGPALIGKWILLQLHPVITLGLPKFLDDVLLHTFRLPPILVKKDYQRLYDFFYTNSANLFIEAEKLGISKDEACHNLLFATCFNSFGGMKIFFPNMLKSIAKAGVEIHTRLANEIRSEVKSAGGKITMSAMEKMPLMKSVVYEALRVDPPVASQYGRAKQDLKIESHDAVFEVKKGEILFGYQPFATKDPKIFDRPGEFVADRFVGEEGEKLLKHVLWSNGPETESPTVGNKQCAGKDFVVMVSRLFVTEFFLRYGTLNVDVGTSALGSSITITSLKKA
What is the function of this protein?
Cytochrome P450 of the CYP74A subfamily involved in the biosynthesis of jasmonic acid from lipoxygenase-derived hydroperoxides of free fatty acids.  Catalyzes the synthesis of unstable allene oxide, which is further converted spontaneously by hydrolysis or cyclization.  Metabolizes 13- but not 9-hydroperoxides of linoleic and linolenic acids.  Can use 15S-hydroperoxy-11(Z),13(E),17(Z)-eicosatrienoic acid (15-HPET) and 13S-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid (13-HPOT) as substrates, but only 50% activity with 13S-hydroperoxy-9(Z),11(E)-octadecadienoic acid (13-HPOD).
What are the official names of this protein?
Allene oxide synthase 2, chloroplastic, LeAOS2, Cytochrome P450 74A.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Peripheral membrane protein; Stromal side.
Protein: CNTF_CHICK
Sequence: MAAADTPSATLRHHDLCSRGIRLARKMRSDVTDLLDIYVERQGLDASISVAAVDGVPTAAVERWAEQTGTQRLLDNLAAYRAFRTLLAQMLEEQRELLGDTDAELGPALAAMLLQVSAFVYHLEELLELESRGAPAEEGSEPPAPPRLSLFEQKLRGLRVLRELAQWAVRSVRDLRQLSKHGPGSGAALGLPESQ
What is the function of this protein?
CNTF is a survival factor for various neuronal cell types.  Seems to prevent the degeneration of motor axons after axotomy.
What are the official names of this protein?
Ciliary neurotrophic factor, CNTF, Growth-promoting activity, GPA.
What is the protein family that this protein belongs to?
Belongs to the CNTF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK36_SACOF
Sequence: MKIRASVRKICTKCRLIRRRGRIRVICSNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NRDR_RHIME
Sequence: MRCPYCGSEDSQVKDSRPAEDGNAIRRRRICPDCGGRFTTFERVQLRELMIIKKTGRKVPFDRDKLLRSFEIALRKRPVDRDRIERAVSGIVRRLESSGETEIPSEEIGLQVLEALKSLDDVAFVRYASVYRDFSHAEDFEKVIAEISAKIARDPGE
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PLPL7_CAEEL
Sequence: MSFFYSLFAPLIFLVTFIYNHVLLILFTVCIIGAAAFFVSYYLFGYSNTPSSASSSATPSSRNSPNKERSKKVPTILETDNEDDEIRVNGSPKSGTPTNTQTIEPPTSLNLNMVNSASGSNLSGARRMRKRDWAKKLYKSLVQDSPGRTPTDESSDEENANVVMGGGSVPRRRSKHGNSSRRRQSTAFQLAKDLIRRGSRSYFRQNQENNKDTRVRPPQEFFEPTDLPEIPQNLQPEIFYILHNLKMLELPSEWKLDPREIEVRSFQAGDYIVKPGESDDAIYVAIDGELTVHIRHMEGKEYLVKCIPAGGSFFSLLSMLDILMDFPSIFRTVALKAADPCRVAKFPITSFRESYHKNPEAWIRPIQIVITRLLHVTLTTLHQYMGLSSELMRRRRDDDRHRNGSSTSKLQLSLSLKKKEKPFNINDNEQDQLIVARKWMAEAFGLVADDVVSEQIGSKIHLESYEAGHVIIEQGAEEEVLMMVLHGNLILAQYGSDFFAQIERESLFDEENNEEDESAVIRVTARELVGGLQILTNEPSFYTIRAAVQTRVAIMKKKDFSAFLEAHPEIYLPVAHSVLRRLSPFLRGVDFALDWVLVDSGHACYRAGDMADSLFVVLSGRLRSVEKKTVVEEFGRGDVLGMMEVLTKKPRATTVLAVRFSQLARVPEGLLNFIKMQYPQVGFRLVQLLGQYYSQTNRRAPFAAPTVIRTNELGATDPMSHIKNLHTIAVVPASPDVPLVPFTCELYHALSSNLRVLRLSSQKVAACLDPSVLEKQADFRLMHWLNVQEDTYPLVIYECDFTQTNWTRRCLRQADAILVVAIGGKTPEKQTLMRELMNMNQDGVRTNKELILLWPESTKTPSGTIEWLKNSYFSGHHHIRAPKRMLQWNRKFRKMSRAEVMTPTSVENEVIEYYEKNVFWTPDRRSDFSRLARILTGNAIGLVLGGGGARGAAHVGVLRALREEGIPVDIVGGTSIGSLIGGLYAETPDDVVVETRAASWFNGMSSLWRKLLDLTYAHSAMFTGAQFNFSIKDLFEERLIEDLWISYFCISTDISTSEMRVHRSGPLWAYCRASMSLAGYLPPLCDPQDGHLLLDGGYVNNVPADVMRNLGARCVIACDVGSIEETNLYDYGDSLSGMWVLLKRLNPFGTPPRILNMEEIQSRLAYVSCVRQLEVVKKASYCRYLRPPIEPFKTLDFPKFQEIMELGLKYGREACHELITNDRAGILGDEKETRKFKRQQSRREKPDVSRAVSFTDLAAAMSKIPVVRPTLRHSMSLNPSANGPVGRAGDHFLLDDDLFNDTDYYEEESSQSENGNESFTEDEDLVIGPPSSSSSGGNVSENPRGTTPRPPSS
What are the official names of this protein?
Patatin-like phospholipase domain-containing protein ZK370.4.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YFM6_YEAST
Sequence: MMVDPLYKGGLTKPLCSSGLRPITDSCVVIPNFDNSVRSIIVVNILVFAGILYSQFRNTLSIFSLWCPNTRAVFLFICPCLLYFYQGIFSTDEQIGTFNIIWMLRRLTIELIIRNLNAEKER
What are the official names of this protein?
Putative uncharacterized protein YFR056C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y065_SYNC1
Sequence: MPAIKDWPEDERPREKLLHRGAEALSDAELLALILRSGDAASGHSALDQGRLLIQQFDTLRQMATATTSELQAIKGIGPAKAAELQAVFELARRFGRNPLRPGDRYTSPQAVFAHFHERLRDHKRERFIALLLDSKNRLLREVGISEGSLTASIVHPRDVFAPVVRESAAAVLFVHNHPSGDPSPSREDLDITQRLREVGELMGVRVLDHIIIGDEGYVSLADRGVL
What are the official names of this protein?
UPF0758 protein Pcar_0065.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: ARGC_BURL3
Sequence: MSQPTVYIDGDQGTTGLLIHERLRGRIDLQLVTLPDAERKDPVRRAEAINAADIAILCLPDAAAREAVGFIRNPAVRVIDASSAHRTQPDWVYGFPEMANGHAQTIAHARRVTNPGCYPTGAIALLRPLQQAGLLPRDYPVSIHAVSGYSGGGRAAVDAFESGDASQAKPLQVYGLALAHKHVPEIQLHAGLTNRPMFVPAYGAYRQGIVLTVPIELRLLPAGVTGEQLHACLAHHYADARHVDVTPLADTQAITHLDPQALNGTNDMRLGVFVNAEHGQVLLSAVFDNLGKGASGAAVQNLDLMLGAADVAKAA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDM3A_RAT
Sequence: MYKSLLDKAGLGSITSVRFLGDQQSVFVSKDLLKPIQDVNSLRLSLTDNQTVSKEFQALIVKHLDESHLLQGDKNLVGSEVRIYSLDPSTQWFSATVVHGNPSSKTLQVNCEEIPALKIVDPALIHVEVVHDNFVTCGNSTRIGAVKRKSSENNGSSVSKQAKSCSEVSPSMCPVQSVPTTVCKEILLGCTAATPSSNRQQNTPQAANSPPNIGAKLPQGCHKQSLPEEISSCLNTKSEVLRTKPDVCKAGLLSSKSSQVGAGDLKILSEPKGSCIQPKTNTDQESRLESTPQPVTGLTKECLVTKTSSKAELDNATAPELQKRLEHTASTPDGLSDKPEVEAGVTRLNSCSEKKVGPSDLGSQSQNLKETSVKVDHDSCCTRSSNKTQTPPARKSVLTDPDKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKDQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDSEAIGLWLPLTKNVVGTDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRLKRKNCQQGAAYKTFSWIRCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPALKEDLKQASLSGEKPSLGTMVQQSSPVLEPAAVCGEAPSKPASNVKPICPANTSPLNWLADLTSGNVNKENKEKQLTMPILKNEIKCLPPLPPLNKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASLVQNKTSSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNTELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNEKEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLRTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPADHDPIHDQSWYLDRSLRKRLYQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRHLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKAVNPVWANVNSSAHWR
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.  Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'.  Demethylation of Lys residue generates formaldehyde and succinate.  Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation.  Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin.  Directly regulates expression of PPARA and UCP1 and is involved in obesity resistance (By similarity).
What are the official names of this protein?
Lysine-specific demethylase 3A, JmjC domain-containing histone demethylation protein 2A, Jumonji domain-containing protein 1A, Testis-specific gene A protein, Zinc finger protein TSGA, [histone H3]-dimethyl-L-lysine(9) demethylase 3A.
What is the protein family that this protein belongs to?
Belongs to the JHDM2 histone demethylase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity).
Protein: RS11_RHIWR
Sequence: MAREPQRIRRRERKNITAGVAHVNASFNNTMITITDAQGNAIAWSSAGMMGFKGSRKSTPYAAQVAAEDAGKKAAEHGVRTLEVEVKGPGSGRESALRALQAVGFHITSIRDVTPIPHNGVRPSKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: DTD_SHIF8
Sequence: MIALIQRVTRASVTVEGEVTGEIGAGLLVLLGVEKDDDEQKANRLCERVLGYRIFSDAEGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPSFSKGASPDRAEALYDYFVERCRQQEMNTQTGRFAADMQVSLVNDAPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
Probable D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_METTP
Sequence: MGRLNYSITPEGRFARAMGVELPISPKHAREICRAIRGMKVEAAERFLQDVIALKRAVPFRRYNRNVPHRHGLVGWPAGRFPQKAARAVLRVLENAIGNAEYKGLEKERLVIGYANTKKGRTFRGWMPRAMGRATPKNQETVSIEMILTEVR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: OTC_ECOL5
Sequence: MATSLKNRNFLKLLDYTPAEIQYLIDLAINLKAAKKSGNEKQTLVGKNIALIFEKSSTRTRCAFEVAAFDQGAQVTYIGPSGSQIGHKESMKDTARVLGRMYDGIEYRGYGQNIVEELGEFAGVPVWNGLTNEFHPTQILADLMTMLEHAPGKTLPELSFAYLGDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPDEALVTQCREIASVTGARITLTEDVEEGVYDVDFLYTDVWVSMGEPKEAWAERVSLMAPYQINQQVITATRNPEVKFMHCLPAFHNEHTTVGREIEMAYGSKDWKLLKRFLNRPTLLFSMKQKTGCTPLKR
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_STAA9
Sequence: MPAVTYEHIKTCKQSGARLGIVHTPHGSFETPMFMPVGTKATVKTMSPEELRQIEAKIILGNTYHLWLQPGNDIIKHAGGLHKFMNWDGPILTDSGGFQVFSLSNLRKITEEGVEFRHHTNGSKLFLSPEKSMQIQNDLGSDIMMAFDECPPMPAEYDYVKKSIERTTRWAKRCLDAHQRPEDQALFGIIQGGEYEDLREQSAKDLVELDFPGYAIGGLSVGEPKPVMYKMVEHTEQFMPKDKPRYLMGVGSPDALIECSIRGMDMFDCVLPTRIARNGTCMTSQGRLVIKNAKFADDLRPLDENCDCYTCQNYSRAYIRHLIKAEETFGIRLTTIHNLHFLLKLMEDIRQAIREDRLLDFKEEFFEQYGLNVENPKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RADA_METS5
Sequence: MADQVEEKKRIKTVKDLSGVGQAVLNKLTEAGYSTLESIAVASPQDLSTAAGIPITTAQRIIKEARDALDIRFKTALEIEQERASVKKITTGSQALDGLLGGGIETRTMTELFGEFGSGKTQICHQVSVNVQLPPERGGLSGKALYIDTEGTFRTERIKAMASALGLEPKEVLQNIMSIRAINTDHQIAIVEELQDIIAKDNSIKLVVVDSITSHFRAEYSGRENLAVRQQKLNRHLHQLVRLAEIYDLAVIVTNQVMARPDMFYGDPTVAVGGHTLYHVPGIRVQIKKSRGNRRIARMVDAPHLPEGEVVFSITNTGIRDAEE
What is the function of this protein?
Involved in DNA repair and in homologous recombination.  Binds and assemble on single-stranded DNA to form a nucleoprotein filament.  Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
What are the official names of this protein?
DNA repair and recombination protein RadA.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RecA-like protein family.