PharMolix/UniProtQA huggingface dataset:
Protein: WHIA_MYCBO
Sequence: MAMTTDVKDELSRLVVKSVSARRAEVTSLLRFAGGLHIVGGRVVVEAELDLGSIARRLRKEIFELYGYTAVVHVLSASGIRKSTRYVLRVANDGEALARQTGLLDMRGRPVRGLPAQVVGGSIDDAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGAARRLGVGAKAREVRGADRVVVRDGEAIGALLTRMGAQDTRLVWEERRLRREVRATANRLANFDDANLRRSARAAVAAAARVERALEILGDTVPEHLASAGKLRVEHRQASLEELGRLADPPMTKDAVAGRIRRLLSMADRKAKVDGIPDTESVVTPDLLEDA
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: CAID_SALPA
Sequence: MSESLHLTRNGPILEITLDRPKANAIDAKTSFAMGEAFLNFRDDPELRVAIITGGGEKFFSAGWDLKAAAEGEAPDADFGPGGFAGLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCAENASFALPEAKLGIVPDSGGVLRLPKLLPPAIVNEMVMTGRRMSAEEALRWGIVNRVVSQSELMDSARELAQQLVNSAPLAIAALKEIYRATSEMPVEEGYRYIRSGVLKHYPSVLHSEDALEGPQAFAEKRDPVWKGR
What is the function of this protein?
Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.
What are the official names of this protein?
Carnitinyl-CoA dehydratase, Crotonobetainyl-CoA hydratase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: ARL5B_HUMAN
Sequence: MGLIFAKLWSLFCNQEHKVIIVGLDNAGKTTILYQFLMNEVVHTSPTIGSNVEEIVVKNTHFLMWDIGGQESLRSSWNTYYSNTEFIILVVDSIDRERLAITKEELYRMLAHEDLRKAAVLIFANKQDMKGCMTAAEISKYLTLSSIKDHPWHIQSCCALTGEGLCQGLEWMTSRIGVR
What is the function of this protein?
Binds and exchanges GTP and GDP.
What are the official names of this protein?
ADP-ribosylation factor-like protein 5B, ADP-ribosylation factor-like protein 8.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
Protein: LOXE3_RAT
Sequence: MAVYRLCVTTGSYLKAGTLDNIYATLVGTCGESPKQKLDRVGRDFATGSVQKYKVRCASELGEILLLRLHKERFAFFCKDPWYCSRICVTTPDGSVVHFPCYQWIDGYCTVELRPGTARTICQDALPLLLDHRKRELQARQECYRWKIYAPGFPRMVDVSSFEEMESDKKFALTKTAPCADQDDNSGNRYLPGFPMKVDIPSLLHMEPNIRYSATKTASLIFNALPASLGMKIRGLLDRKGSWKRLDDIRNIFWCHKTFTSEYVTEHWCEDSFFGYQYLNGVNPIMLHCLSSLPSKLPVTNDMVAPLLGPGTCLQTELERGHIFLADYWILAEAPVHCLNGRQQYVTAPLCLLWLNPQGVLLPLAIQLSQIPGPESPIFLPTDCELDWLLAKTWVRNSEFLVHENNTHFLCTHLLCEAFSMATLRQLPLCHPVYKLLLPHTRYTLQVNTIARATLLNPDGLVDKVTSIGRRGLIYLMSTGLAHFTYTDFCLPDSLRARGVLTIPNYHYRDDGLKIWAAIERFVSEIVSYYYPNDACVQQDSELQAWVGEIFAQAFLGRESSGFPSRLCTPGELVKYLTAIIFNCSAQHAAVNSGQHDFGAWMPNAPSSMRQPPPQTKGNTTMESYLETLPEVNTTCSNLLLFWLVSQEPKDQRPLGTYPDEHFTEEAPRQSIAAFQKCLAQISKDIRARNESLALPYAYLDPPLIENSVSI
What is the function of this protein?
Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity.  The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones.  In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides.  In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins.  Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss.  In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (By similarity).  Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity).  Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (PubMed:23382512).
What are the official names of this protein?
Hydroperoxide isomerase ALOXE3, Epidermis-type lipoxygenase 3, Epidermal LOX-3, e-LOX-3, eLOX-3, Hydroperoxy dehydratase ALOXE3, Hydroperoxy icosatetraenoate dehydratase, Hydroperoxy icosatetraenoate isomerase.
What is the protein family that this protein belongs to?
Belongs to the lipoxygenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2H_BOTNR
Sequence: SLFELGKMILQETGKNPAKSYGAYGCNCGVLGRGKPKDATDRCCYVHKCCYKDRYSYSWKDKTIVCGENNPCLKELCECDKAVAICLRENLGTYNKKYRYHLKPFCKK
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that lacks enzymatic inactivity, but induces myotoxicity (PubMed:26927324).  Also causes an inflammatory activity that is demonstrated by mice paw edema induction and pro-inflammatory cytokine IL-1 (but not TNF-alpha) elevation (PubMed:26927324).  Also shows antimicrobial activity against Gram-positive and Gram-negative bacteria (PubMed:26927324).
What are the official names of this protein?
Basic phospholipase A2 homolog BnuTX-I, svPLA2 homolog, Lys49 PLA2-like.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_ECOLC
Sequence: MSLSTEATAKIVSEFGRDANDTGSTEVQVALLTAQINHLQGHFAEHKKDHHSRRGLLRMVSQRRKLLDYLKRKDVARYTQLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: HADB_CLODI
Sequence: MSEKKEARVVINDLLAEQYANAFKAKEEGRPVGWSTSVFPQELAEVFDLNVLYPENQAAGVAAKKGSLELCEIAESKGYSIDLCAYARTNFGLLENGGCEALDMPAPDFLLCCNNICNQVIKWYENISRELDIPLIMIDTTFNNEDEVTQSRIDYIKAQFEEAIKQLEIISGKKFDPKKFEEVMKISAENGRLWKYSMSLPADSSPSPMNGFDLFTYMAVIVCARGKKETTEAFKLLIEELEDNMKTGKSSFRGEEKYRIMMEGIPCWPYIGYKMKTLAKFGVNMTGSVYPHAWALQYEVNDLDGMAVAYSTMFNNVNLDRMTKYRVDSLVEGKCDGAFYHMNRSCKLMSLIQYEMQRRAAEETGLPYAGFDGDQADPRAFTNAQFETRIQGLVEVMEERKKLNRGEI
What is the function of this protein?
Involved in the reductive branch of L-leucine fermentation.  Catalyzes the irreversible beta/alpha-elimination of water from (R)-2-hydroxyisocaproyl-CoA to yield isocaprenoyl-CoA.  This beta/alpha-dehydration depends on the reductive formation of ketyl radicals on the substrate generated by injection of a single electron from the ATP-dependent activator protein HadI.  The enzyme is specific for the R-isomer.
What are the official names of this protein?
(R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit.
What is the protein family that this protein belongs to?
Belongs to the FldB/FldC dehydratase alpha/beta subunit family.
Protein: ECHA6_MYCBO
Sequence: MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVLTGQGTAFCAGADLSGDAFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAEIALHTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKFQGA
What is the function of this protein?
Could possibly oxidize fatty acids using specific components.
What are the official names of this protein?
Probable enoyl-CoA hydratase echA6.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: CTXN3_MOUSE
Sequence: MDGGQPVPSPLVPLGNGSDYSMSLEQKTTFVFVILLFIFLGILIVRCFRILLDPYRSMPTSTWADGLEGLEKGQFDHALA
What are the official names of this protein?
Cortexin-3.
What is the protein family that this protein belongs to?
Belongs to the cortexin family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DCUP_CAUVC
Sequence: MTSSSPILKQTPKFLSALEGQSHANPPVWFMRQAGRYLPEYRAVRATAPDFISFCFDPEKAAEVTLQPMRRFPFDASIVFADILLIPGALGQKVWFEAGEGPKLGDMPSVESMAEKAGEAGKALSLVGETLTRVRSALDPDKALIGFAGAPWTVATYMIEKGSSDRSGARTFAYQNPETLDALIQVLVDATIDYLAMQVDAGAQALKLFESWAEGLSEPLFDRLVTQPHIRIIEGLRARGVTVPIIGFPRGAGTLVEDYAARTPVQGVALDTSASAKLGQTIQKTKTIQGALDPLLLRAGGDALLKRVDEMLEQWNQGPYIFNLGHGILPDTPIAHVEAVLERVTGQKVGQ
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen III to yield coproporphyrinogen III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T3HPD_BACC1
Sequence: MKVSKVYTTIDAHVAGEPLRIITGGVPEIKGETQLERRAYCMEHLDHLREILMYEPRGHHGMYGCIITPPASAHADFGVLFMHNEGWSTMCGHGIIAVITVGIETGMFEVTGEKQKFIIDSPAGEVIAYATYRGSEVESVSFENVPSFVYKKDVPIKIDDYEFQVDIAFGGAFYAVVDSKEFGLKVDFNDLPAIQTWGGKIKHYIESKMEVKHPLEEGLKGIYGVIFSDEPKGKDATLRNVTIFADGQVDRSPCGTGTSARIATLFEKGILQKGEIFIHECITEGKFEGEVLSVTAVHTYEAVVPKITGNAFITGFHQFVVDPRDDLNRGFLLG
What is the function of this protein?
Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C).  Is likely involved in a degradation pathway that converts t3LHyp to L-proline.  Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp) in vitro.  Displays no proline racemase activity.
What are the official names of this protein?
Trans-3-hydroxy-L-proline dehydratase, T3LHyp dehydratase, t3HypD, Trans-L-3-hydroxyproline dehydratase.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: RS10_METAC
Sequence: MQKARIRLSGISPKDLDGVCNQVKSIAERTGVNISGPVPLPTKKLVVPTRKSPSGDGTATWDHWEMRVHKRLIDIAADERALRQLMRIQVPKDINIEIVLEG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: SLMA_SALPC
Sequence: MAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKNTSTRLRLIVLLILGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEAQLRQVLREKRMREGEGYTTDENLLASQLLAFCEGMLSRFVRSEFKYRPTDDFDARWPLIAAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CCA_SHEB2
Sequence: MKIYLVGGAVRDSLLNLPIKDKDYLVVGATPEQMLQLGYRQVGKDFPVFLHPKNQQEYALARTERKIGLGYGGFSCHASPDVTLEQDLLRRDLTINAIAQDEKGNLYDPFNGIEDLNARLLRHVSDAFVEDPLRILRVARFAARFHALGFHIAAETLALMRQISASDELNALTAERVWQEVDKSLGGPHPEVFFEVLHQCGALEVLFPEIFALFGVPQPEKWHPEIDTGVHTLMVLAQAALLTDDKSVRFAALVHDLGKALSPKEHLPKHHGHGQKGLPLIKALCTRLRVPNETRDLALLVSDQHQNVHQAFELRAETIVKIFDKADFWRKPERLTQLILACIADMRGRTGFENNPYPQGEYLTQCFLAANNVDIAAIIAAGFQGAEIKQALNLRRIEAVSQFKQKMQTKLPTDEQ
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: HBA_LYNLY
Sequence: VLSAADKSNVKACWGKIGSHAGDYGTEALERTFCSFPTTKTYFPHFDLSHGSAQVKAHGQKVADALTQAVAHIDDLPNALSALSDLHAYKLRVDPVNFKFLSHCLLVTLACHHPAEFTPAVHASLDKFFSAVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PHS_LEGPA
Sequence: MTSDLSSKHCESCEGIGAALNSEQIKNLLPQLNTKWEVTEDNRIIKRAFSFKNFYETMAFVNAIAWIANIENHHPDLEVGYNYCRVHFMTHALNGLTHNDFICAAKIDKLLVD
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: SIBD2_CUPSA
Sequence: MESLFIFAFGMMLSSASALSCIPCVPEECEDPGPCEYGKVLDPCQCCLICRKGPGEICGGPWNLQGVCAEGFACITLSGNPVMNLNGGGQEVGRCRKKY
What is the function of this protein?
Has a role in the innate immune system.
What are the official names of this protein?
Single insulin-like growth factor-binding domain protein-2, SIBD-2.
What are the subcellular locations of this protein?
Secreted.
Protein: CDHB_PSEU3
Sequence: MKPTAFDYIRPTSLPEALAILAEHSDDVAILAGGQSLMPLLNFRMSRPALVLDINDISELQQVRCENDTLYVGSMVRHCRVEQEEIFRSTIPLMSEAMTSVAHIQIKTRGTLGGNLCNAHPASEMPAVITALGASMVCKSEKRGERVLTPEEFFEGALQNGLQSDELLCEIRIPVPSQYVGWAFEEVARRHGDFAQCGAAVLIGAEDRKIDYARIALCSIGETPIRFHALEQWLIGRPVGNDLPADVKLHCREILDVAEDSTMTAENRAKLASAVTSRAIARAADRIVHLDVKRG
What is the function of this protein?
Catalyzes the hydrolitical oxidation of 1,3,7-trimethylxanthine (caffeine) by incorporation of an oxygen atom originating from a water molecule into position C-8 to produce 1,3,7-trimethyluric acid (TMU).  Coenzyme Q0 is the preferred electron acceptor and coenzyme Q2 can also be used, but oxygen and NADP cannot.
What are the official names of this protein?
Caffeine dehydrogenase subunit beta, Caffeine dehydrogenase medium subunit.
Protein: CIPK3_ARATH
Sequence: MNRRQQVKRRVGKYEVGRTIGEGTFAKVKFARNSETGEPVALKILDKEKVLKHKMAEQIRREIATMKLIKHPNVVQLYEVMASKTKIFIILEYVTGGELFDKIVNDGRMKEDEARRYFQQLIHAVDYCHSRGVYHRDLKPENLLLDSYGNLKISDFGLSALSQQVRDDGLLHTSCGTPNYVAPEVLNDRGYDGATADMWSCGVVLYVLLAGYLPFDDSNLMNLYKKISSGEFNCPPWLSLGAMKLITRILDPNPMTRVTPQEVFEDEWFKKDYKPPVFEERDDSNMDDIDAVFKDSEEHLVTEKREEQPAAINAFEIISMSRGLNLENLFDPEQEFKRETRITLRGGANEIIEKIEEAAKPLGFDVQKKNYKMRLENVKAGRKGNLNVATEIFQVAPSLHMVQVSKSKGDTLEFHKFYKKLSNSLEQVVWTNNEVKKETAK
What is the function of this protein?
Involved in the resistance to some abiotic stresses (e. g.  high salt, hyperosmotic stress) in young seedlings, by regulating the expression of several stress-inducible genes (cold- and salt-induced genes but not drought-responsive genes).  Required for the ABA response during germination.  CIPK serine-threonine protein kinases interact with CBL proteins.  Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.  The CBL9/CIPK3 complex acts in the regulation of abscisic acid response in seed germination.
What are the official names of this protein?
CBL-interacting serine/threonine-protein kinase 3, SNF1-related kinase 3.17, SOS2-like protein kinase PKS12.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Protein: RL4_ANADF
Sequence: MAKFDVYDLDKKKVGEIELADAVFAGEVNEHLFYEVVKAKLASDRSGTHAVKNRSLVSGGGKKPWKQKHTGRARQGSTRASQWVGGGKAMGPKPRDYSYDVPKKVRKAALRSALALRSQEQKLVIVQEWKPAEPKTSAAAKVLAKLGARKALVVDAAANAALARSVRNLDGSDFLAAEGLNVYDILKHDALVLTAETAKMLEASLS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: AIM4_LACTC
Sequence: MSKSNYMSYSDEKSSSKSFGFENNNVKNQELGERSIFYDHEWNPEGKAPSGYKNVPYNQYTFKRKSKVEPKLQGFKSIPFPSSEDKQP
What are the official names of this protein?
Altered inheritance of mitochondria protein 4.
What is the protein family that this protein belongs to?
Belongs to the AIM4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERG3_MYCTO
Sequence: MRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSIATTAGWKSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPPWMVFCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFGSFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR
What are the official names of this protein?
C-5 sterol desaturase, Sterol-C5-desaturase.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DAPB_TERTT
Sequence: MTTRIAVTGAGGRMGKILIEAVSLAGGAQLTAAIERPTSSLLGADAGELAGIGKLGVPVVGDLAEVVDGFDVLIDFTAPVATLANAKVCAAAGKGMVVGTTGFSGAEKAEFDETVTSIPVCMASNFSTGVNLCFKLLDMAASVLGDDVDIEICEAHHRHKVDAPSGTALSMGEVVANAVGRNLKDVAVYGREGQTGARERNTIGFATVRGGDVVGDHTVSFLADGERVEISHKASSRMSFGRGAVRAATWLLGKPASRYDMQDVLGLR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_HYPBU
Sequence: MSFVPREAVEQAVKEALEISPKRNFKQSVDLIVVLRDIDLRSPQGRIREVVILPHPPKKHVRICVAADGDMAVKAKEVADRVLTREELQGLVGNRKAAKKIAEFCDWVIVKADLMPLVGRTLAPALGPRGKVPIPVPPNANIAEIVKTYRSAVMLRAKDQPQVMCRVGTEDMPVNEIVDNIFKVLSTLEGKLPNARHNIAKVIVKLTMGPPVEVKLR
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: RSEA_HAEIN
Sequence: MQKEQLSAYMDGEQVETDLIDALLRDEELQASWHSFHTVRSVMRKESAVFLGADFTAKMADLIELEDVKKVDVIAVSQPEPEDAHNSVFMQKLKAFFAPMTQVAVAAGVCLVAVLGVQSFNNKNDASNLPETPVLQTLPFNNAVQEVSYNAPSKDTLTSDQLEKKSRRIGAMLQNYELQRRMHSDALDVSSSQVR
What is the function of this protein?
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE).  ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP).  RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses.  The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E (By similarity).
What are the official names of this protein?
Anti-sigma-E factor RseA, Regulator of SigE, Sigma-E anti-sigma factor RseA, Sigma-E factor negative regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the RseA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Following cleavage by DegS the large fragment of the protein is still in the inner membrane and retains its anti-sigma-E activity.
Protein: RL33_ORITB
Sequence: MSRKKKVLVKLVSSAGTGVFWVKQRNPKTQTEKLSFRKYDPKVRKHVQFTEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RL35_RICCN
Sequence: MPKLKTKSAVKKRFKLTASGKVIASQAGKKHFMRRRTKAQIRNLRGTTILCPQDRYNIKKYFLPYGIN
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: GRPE_HAEIN
Sequence: MSEQEQKVEIPEVEKQEEVVVEETQQAEHSQEFDPLEEAIARVQELEEQLKTQIEEAANKEQDILLRSRAEIENLRRRTEQDVEKAHKFALEKFSKDILNTIDNLERALATPANKEDESVKALFDGVELTLKELVSTVGRFGVEAVGVVGEAFNPDLHQAISMQPAEGFETNQISVVLQKGYTLNGRVIRPAMVMVAA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TILS_BUCAP
Sequence: MIEKIINQYQKKLFLIAYSGGIDSTVLLYKMLKIKEKNPQIKIRAIHINHNLHPSSKKWEEHCIKICHKYKIPIITKEIKILLKKNIEETLRIKRYNTIYNYLLNDEILLTGHHLNDQCETLFLSLKRGSGPTGLSGMSIENFLGKKRIVRPFLTKTKKELQKWACENNLESIEDFSNFNIDYDRNFIRHKLIPILEQRWPFFLKNCFRTTVICREETKLKNIFLKEKIQNLINFDESLNIQNFKNINKEVCKALIRYWISLKNIKMPSYKTIECIYNEIICSKKDSNPKIIIDKNEIRRYKTSLYFIKIQKDISNIFLFWHNTDKKLLLPEDLGYLIKNDKGFILPSPKKNELINIRFQLEGKILILGREKRRKIKKIWQEHNIPPWLRNKIPLLFYNNRFISAIGLFVIKEKIINKEKEIQKNWKISWINNVHFNRKNFFLFY
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCAL_STRE4
Sequence: MTVTGIIAEFNPFHYGHQYLLSQAKGLKIVAMSGNFVQRGEPALVDKWVRAQMALENGADLVVELPFLVSVQSADYFAQGAVDILMRLGIDTLAFGTEQLLDYQKLSRLYSEQAEHMTAYLATLPDHLSYPQKTQSMWEAFAGLSATGDRPNHLLALSYVKASAGKKLQLQPIKRLGAGFHSEAKDQCLSSATAIRKHIADRAFVEKSSPNAALILRAPQVTWEHYFPFLKYHILTAPDLTQFFQVNDELASRISAAIRSVATVDELVEAVATKHYTKARVRRVLTYILVKAVEAPLPEGIHVLGFSKKGQAHLKTIKASVPLISRIGAKPWDQLTQRADTVYQLGHTDMPEQTWGCVPIRPEAMN
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_XYLFA
Sequence: MSRKGSTPQRNVLPDPKYGSETIARFINMVMKSGKKSVAEKIVYGAMNVIGEKNSNAIELLQKALDNVSPAVEVKSRRVGGATYQVPVEVRASRRMALAMRWLIDSSRKRGENSMPHKLAAELLDASESRGGAIKKREETHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.