PharMolix/UniProtQA huggingface dataset:
Protein: DLDH_PIG
Sequence: MQSWSRVYCTLAKRGHFNRIAHGLQGVSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLEKMMEQKSNAVKALTGGIAHLFKQNKVVRVNGYGKITGKNQVTATKADGSTEVINTKNILIATGSEVTPFPGITIDEDTVVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVELLGHVGGIGIDMEVSKNFQRILQKQGFKFKLNTKVIGATKKSDGNIDVSIEAASGGKAEVITCDVLLVCIGRRPFTQNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHIIGPGAGEMINEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKAINF
What is the function of this protein?
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (By similarity).  The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity).  A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity).  In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228).  Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
What are the official names of this protein?
Dihydrolipoyl dehydrogenase, mitochondrial, Dihydrolipoamide dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2- oxoglutarate dehydrogenase complex is required for histone succinylation.
Protein: KAD_STRR6
Sequence: MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTEMGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLAELGIELEGIINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCNB3_DROME
Sequence: MAPTKATTRAAITSGHHQLQQAVNPILGALGAATRKGLTRRAAATGNIDPNVENMQTRAKRKADHSPIKNDKIKRSALGNLTNNVKIMTLHPAQDEEQSGVGKKPTAQQLQALMDAKKQENLSVNVFGASKMTTRASSKVEDSVENCHKVLDKLEEALARPKPRPKAVPAAKKTVLGEVQLPAMPNPMQIPVLLPPTHNLAAPQVAAVKPVRRISNDFNKTEDSLYMSALEDVSSCDSMRLSGNFEAARRRSAKLQQKTEQQPQPLLLTLPETAPSQVVPIPPVPEEVEDFDRKNWDDPFQVSHYAMDIFNYLKVREAEFPIADYMPRQIHLTTWMRTLLVDWMVEVQETFELNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIACKYDERQPPLIEDFLYICDGAYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARCAKVPMPTLTLARYILELSLMDYANISFSDSQMASAALFMALRMHGGPGQLDKQTWTSTLIYYTGYQLADFAEIVTALNAGLHRKPRATIKTIRNKYSHKIFHEVAKVPLLTNQELFQGNLDLNESNLS
What is the function of this protein?
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division.  Probably functions redundantly with other cyclins in regulation of cell cycle.  Its presence may be required to delay a deadline for completing cytokinesis that is ordinary imposed by nuclear envelope reformation.  Degradation of CycB and CycB3 promote cytokinesis furrow initiation and ingression.  Required with CycB for female fertility.
What are the official names of this protein?
G2/mitotic-specific cyclin-B3.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
Protein: DAG1_PIG
Sequence: MRMSAGLSLLIPLWGRTFLLLLSVAVTQSRWPSEPSDAVRDWENQLEASMHSVLSDLHEAVPTVVGIPDGTAVVGRSFRVTIPTDLIASGGEIIKVSAAGKEALPSWLHWDPQSHTLEGLPLDTDKGVHYISVSAARLGANGSHVPQTSSVFSIEVYPEDHSEPQSVRAASPDPGEVVSSVCAADEPVTVLTVILDADLTKMIPKQRLDLLQRMQSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVIENGALLSWKLGCSLNQNSVPDIHGVEVPAREGAMSAQLGYPVVGWHIANKKPPLPKRIRRQIHATPTPVTAIGPPTTAIQEPPSRIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIFQTPTLGPIQPTRVSEAGTTVPGHIRPTMTIPGYLEPTAVATPPTPTTKNPRVSXPTKKPRTPRPVPRVTTKAPITRLETASPPTRIRTTTSGLPRGEPNQRPELKNHIDRVDAWVGTYFEVKIPSDTFYDNEDTTTDKLKLTLKLREQQLVGVKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGGLSAVDAFEIHVHRRPQGDRAPARFTAKFVGDPAPVVNDIHKKIALVKKLAFAFGDRNCSTITLQNITRGSIVVEWTNNTLPLEPCPKEQITGLSRRIAEDDGKPRAAFSNALEPDFKAMSIAVTGSGSCRHLQFVPVAPPKRVPSEAPPTEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGKLTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETTPLNQDTVGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP
What is the function of this protein?
Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton.  Acts as a cell adhesion receptor in both muscle and non-muscle tissues.  Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton.  Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity).
What are the official names of this protein?
Dystroglycan 1, Dystroglycan, Dystrophin-associated glycoprotein 1.
What are the subcellular locations of this protein?
[Alpha-dystroglycan]: Secreted, extracellular space. SUBCELLULAR LOCATION: [Beta-dystroglycan]: Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Cell membrane, sarcolemma. Postsynaptic cell membrane. Note=The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity). In peripheral nerves, localizes to the Schwann cell membrane. Colocalizes with ERM proteins in Schwann-cell microvilli (By similarity).
Protein: PCD18_HUMAN
Sequence: MHQMNAKMHFRFVFALLIVSFNHDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSTVRFRAMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLLKCMIFEYAESVTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPTQPQQQHPHQSLEDDAQPADSGEKKKSFSTFGKDSPNDEDTGDTSTSSLLSEMSSVFQRLLPPSLDTYSECSEVDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTTNCGPPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.
What are the official names of this protein?
Protocadherin-18.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: FOLD1_SALTO
Sequence: MSTSMSVARSLPGGPVAEQILAEVAQEVTQLRAAGVTPALATVLVGDDDASVGYIRIKQRQAVQLGFASPHVRLPASASQADLQAVVTQLSADTSVHGVLVQHPVPPHLDFDRAMQALDPEKDVDGMHPVNLGRLALGLPGPTPCTPAGIEALLAYHEVPVAGREVVVLGRGATLGRPLAMVLAQKRPTANAAVTVVHTGVPDWPRYTRRAEIVVAAAGVPGLVRPEHLRPGAVVVNGGVRYAGRRLLPDVDESCATVAGAMTPRVGGVGPTTVAMLFRNAVRAARRTRSSRTPVRLPDSGAPAGR
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 1.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL18_CLOBB
Sequence: MFKKVDKKASRTKRHLRVRKKVFGTPDRPRLSVFRSEKNIYVQIIDDVNAVTIVAASSLDKEFSTNNGGNKEGAKLVGAAVAKKAIEKGITEVVFDRGGYVYHGRVQELAEGAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RS16_DEBHA
Sequence: MSTPSVQTFGKKKTATAVAHVKAGKGLIKVNGAPITLVQPEILRFKVYEPLTLVGLDKFQNIDIRVKVSGGGHVSQVYAIRQAIAKGLVAYHQKFVDEASKNELKKVFASYDKTLLVADSRRMEPKKFGGRGARARFQKSYR
What are the official names of this protein?
40S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: SYT2_RAT
Sequence: MRNIFKRNQEPIVAPATTTATMPLAPAAPADNSTESTGTGESQEDMFAKLKDKFFNEINKIPLPPWALIAMAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK
What is the function of this protein?
(Microbial infection) Receptor for C. botulinum neurotoxin type G (BoNT/G, botG); unlike the case with BoNT/B interaction is not improved in the presence of gangliosides (PubMed:15123599).  The toxin binds to the vesicular domain of Syt2 (residues 1-61) (PubMed:15123599).
What are the official names of this protein?
Synaptotagmin-2, Synaptotagmin II, SytII.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm.
Protein: RS2_METM6
Sequence: MSDENLLTTLDTYLASGIHIGTQQKTEDMRRFIYRVRADGLYVLDVRKTDERLRLAAKFLSNYEPEDIMAVTRRVYSVGPLKKFGQVTGINTVAGRFVPGTLTNPSAKKFAEPEVLFLSDPRVDKQALKEAIEIGIPVVGMCDTEHLTAHIDFIIPTNNKGRKSVSLMYYLIAREYMKNRGLIGEEVPFSYDDFLEKAMNVKVKMNTAPRQRGRFQRRPRR
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: IF2B_THEGJ
Sequence: MSESIDFYDFERLLDKAYEELPENVKSHKSRFEVPPAVVTIAGNRTIIENFVDIAEAMNRDPSHLLKFILREVATAGTLEGRRVILQGRFTPYLIANKLKKYLKEYVICPVCGSPDTKIIKRDRFYFLKCEACGAETPIQHL
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit beta, aIF2-beta, eIF-2-beta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: RL2_IGNH4
Sequence: MGKRLRVQRHGRGTPQWRNRGHLRVAPGRYPSPEVLKLDETYEGYVVELKHDPGRWVPLAHIVIPNVADFWIPAAEGMYTGQKVQIGPNAAPVNGNILPLYAIPEGTQIFNVEIRPGDGGKLARSGGAYAILVGKSGNSAIIQLPSGKVKQVNAKARATIGIAAGAGRDEKPLLKAGNAYYKWKAKAKKWPVVRGVAMNAVNHPHGGGNHQSPGYPTTVARNAPPGQKVGHIAARCTGRGCKQAKARLGLK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SYL_NOCFA
Sequence: MQDTRATESDVPEHRYNAALAGRIERRWQQRWLERGTFHAPNPTGPLAGPTATLPADKLFVQDMFPYPSGAGLHVGHPLGYIATDVFARYHRMRGRNVLHALGYDAFGLPAEQYAVQTGAHPRDTTESNIATMQRQLDRLGLGHDRRRSFATTDPEYYRWTQWIFLQIYNAWYDLELNRARPISELEEQFASGARPAPDGKDWASMSQAERAAVIDSYRLVYQTDSMVNWCPGLGTVLSNEEVTAEGRSERGNFPVFRKRLWQWMMRITAYADRLVDDLDLLDWPENVKAMQRNWIGRSRGAQVRFDSPAGQIEVFTTRPDTLFGATYVVLAPEHDLVDALAAAQWPADTDPRWTGGAATPAEAVAQYRKSIAAKSDLERQENKEKTGVFLGVHAVNPVNGARVPIFIADYVLSGYGTGAIMAVPGHDQRDWEFATAFGLPIVEVISGGDITAAAHTGEGELVNSDYLNGLSVEEAKATVIGRLEADGHGTGTIQYKLRDWLFARQRYWGEPFPIVYDEDGAPHALPESMLPVRLPELDDFAPVTFDPDDADSEPSPPLAKATDWVHVELDLGDGPKKYRRDTNVMPNWAGSSWYQLRYADPTNADAFCAKENEQYWLGPRTAEHGPDDPGGVDLYVGGVEHAVLHLLYARFWQKVLFDLGYVSSSEPYRRLFNQGYIQAFAYTDPRGAYVPAAEVVERDGAFFWTDATGTEIEVSQEYGKIGKSLKNAISPDEVCDQFGADTFRFYEMSMGPLDTSRPWSTKDVVGAHRFLQRVWRLVVDEETGASRVTEDAPTDETLRFLHRTIAGVDEDFAALRDNTAGAKLIELTNHLTKSYPSGTPRAAVEPLVLMLAPLAPHVAEELWERLGHSESLAHGPFPVADPAWLVEETVEYPIQVNGKVRSRIQVPADADNAAIEAAALADEKIAALLAGATPRKLIVVPGRLVNIVA
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_ECO27
Sequence: MSDNDTIVAQATPPGRGGVGILRISGLKAREVAETVLGKLPKPRYADYLPFKDADGSVLDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTIPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNDVIADLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPAEIWPEFIARLPAKLPITVVRNKADITGETLGMSELNGHALIRLSARTGEGVDVLRNHLKQSMGFDTNMEGGFLARRRHLQALEQAAEHLQQGKAQLLGAWAGELLAEELRLAQQNLSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_MARN8
Sequence: MTELKNDRFLRALMRQPVDRTPVWMMRQAGRYLPEYRATRAKAGDFLSLCKNTPLACEVTLQPLERYPLDAAILFSDILTIPDALGLGLYFETGEGPKFRKVIRSEADVDALPRMNAESDLDYVMNAVSTIRRELNGRVPLIGFSGSPWTLATYMIEGGSSKTFSEAKKLMYGQPEVMHRLLDHLADSVIDYLNGQIKAGAQAVQIFDTWGGVLSSWAYEEFSLRYMTKIVDGLIRESEGRRVPVIVFTKNGGQWLESIADCGADAVGLDWTTDIGNARARVGDKVALQGNMDPAMLYAPKARIRQEVADILKRYGSGSGHVFNLGHGITPDVDPEHAGAFIEAVVELSGQYHQ
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSG_PSEAE
Sequence: MDFLPLFHSLQGRLALVVGGGEVALRKARLLADAGARLRVVAPQIHIELRHLVEQGGGELLERDYQDGDQPGCALIIAATDDEPLNAEVSRAANARGIPVNVVDAPALCSVIFPAIVDRSPLVVAVSSGGDAPVLARLIRAKLETWIPSTYGQLAGLASRFRHRVKELLPDLQQRRVFWENLFQGEIAERVLAGRPAEAERLLEEHLAGGLAHIATGEVYLVGAGPGDPDLLTFRALRLMQQADVVLYDRLVAPSILELCRRDAERLYVGKRRAEHAVPQDRINRLLVELASQGKRVLRLKGGDPFIFGRGGEEIDELAAHGIPFQVVPGITAASGCAAYAGIPLTHRDHAQSVRFVTGHLKDGTTDLPWQDLVAPGQTLVFYMGLVGLPVICEQLVAHGRSAQTPAALIQQGTTAQQRVFTGTLENLPQLVAEHEVHAPTLVIVGEVVQLRDKLAWFEGAREDA
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: HIS7_PERMH
Sequence: MRKASIKRETKETQIELSLNLDGSGKYSIDTPVGFLNHMLETFSKHSLIDLEVLASGDVHVSHHHTVEDVGIVLGMAVKEALGDKKGIRRFGYAIVPMDEALSLCSIDISGRPLLFYDDLGLRGKITNFDFELMEEFFKGFTLYSGITVHLKALSGKNLHHIAESLTKSLAVALRQAIEIDPRRKDTPSTKGSL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSRG_KLEP7
Sequence: MNVTLVEINIKPERVDEFLEVFRANHEGALREPGNLRFDVLQDPEVKTRFFIYEAYKDDEAVLAHKKTPHYLACVEKLEEMMSQPRQKRSFIGLLPQV
What is the function of this protein?
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.  Catalyzes the conversion of (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5-phosphonooxypentane-2,4-dione (P-HPD).
What are the official names of this protein?
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase, Autoinducer 2-degrading protein LsrG, AI-2-degrading protein LsrG, Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase, Phospho-AI-2 isomerase.
What is the protein family that this protein belongs to?
Belongs to the LsrG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_PSEE4
Sequence: MSVELWQQCVELLRDELPAQQFNTWIRPLQVEAEGDELRVYAPNRFVLDWVNEKYLGRLLELLGEHGNGLAPALSLLIGSRRSSAPRAAPNAPVSAAVAATMAQQTQQAAQVVVPSEPIVVPVAEPVLSEVEEPSSRDSFDSMSDSGSVPAASGRTEQRTVQVEGALKHTSYLNRTFTFETFVEGKSNQLARAAAWQVADNPKHGYNPLFLYGGVGLGKTHLMHAVGNHLLKKNPNAKVVYLHSERFVADMVKALQLNAINEFKRFYRSVDALLIDDIQFFARKERSQEEFFHTFNALLEGGQQVILTSDRYPKEIEGLEERLKSRFGWGLTVAVEPPELETRVAILMKKADQAKVELPHDAAFFIAQRIRSNVRELEGALKRVIAHSHFMGRDITIELIRESLKDLLALQDKLVSVDNIQRTVAEYYKIKISDLLSKRRSRSVARPRQVAMALSKELTNHSLPEIGDMFGGRDHTTVLHACRKINELKESDADIREDYKNLLRTLTT
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPG_RALSO
Sequence: MGAPHEKMAFQAEVKQLLHLMIHSLYSNKEIFLRELVSNASDAVDKLRFEGIADPSLLEGGGELGIRIGFDAQARTVTIADNGIGMSRDEAIRNLGTIARSGTREFFSQLSGDQQKDAALIGQFGVGFYSAFIVADRVTVESRRAGVPAAEGVRWESAGDGEFTVDAIERAERGTTITLHLREGEDDFLSAWRLKSIVQKYSDHISLPIAMRKESWDEEKKEMVAQDEWETINQASALWARPRADVTDEQYIAFYQHIAHEQGQPLAWTHNRVEGRSEYTQLLYLPTNAPFDLWDRERRSGLKLYVKRVFIMDDAEQLLPAYLRFVKGVIDSADLPLNVSREILQESRDVKAIREGSTKRVLGMLESMADSDDAAEKDKYATFWQHFGQVLKEGLGEDFANKDRIAKLLRFASTHNAGDEQTVSLADYIGRMKDGQDKIYYVSAENWTAAKSGPHLEVFRKKGVEVLLLTDRVDEWMLSFLHDFEEKALVSVARGGLDLGALEDEAERAEHAKVEGEFKPLVDRAKAVLADKAKDVRITHRLTDSPSCLVADEGDISGTLARLLKQAGQKAPDTKPVLELNPAHPLVRKLALLESVTGGEADRAAFEDRLHVLFDQALLAEGGSLADPADYVQRVNRLLA
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_LIGS1
Sequence: MSIKAEEISALIKQQLANYQDELTVDEVGTVTYVGDGIARANGLDNALAGELVEFDDGTYGMAQNLESNDVGIIILGSFKGIREGDTVKRTGRIMEVPVGEELIGRVVNPLGQPIDGLGEVKTNKTRPVERKAPGVMERQSVTEPLQTGLKAIDALVPIGRGQRELVIGDRKTGKTSVAIDTIINQKDQDMICIYVAIGQKDSTVRTSVETLRKFGAMDYTIVVSAGPSSPAPLLYLAPYAGAAMGEEFMFNGKHVLIVYDDLSKQADAYRELSLILRRPPGREAYPGDVFYLHSRLLERAAKLSDELGGGSMTALPFIETKAGDVSAYIPTNVISITDGQIFLDSDRFYSGIRPAIDAGTSVSRVGGNAQVKAMKKVAGTLRTDLASYSELESFAQFGSDLDEATQAKLNRGRRTVEVLKQPLHKPLPVEKQVLILYALTHGFLDPVKVDDILPYQDGLFDYFDANHKDLLDEIANTGKLPETEKLDAAIKEYAATFQASEK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GMT_ASPFU
Sequence: MADDKKTNEYTIEMDKLDHGNKDFEAPAPAVRPRGPPVAQLANNPILPVLAYCGSSILMTVMNKYVLSGRDFNLNFFLLCVQSIVCIVAIQTCKVSKLITYRDFNSDEAKKWFPITLLLIGMIYTGSKALQYLSIPVYTIFKNLTIILIAYGEVLWFGGSVTGLTLFSFGLMVLSSIIAAWADIKHAVESSGDATAKVSTLNAGYIWMLINCLCTSSYVLGMRKRIKLTNFKDFDTMFYNNLLSIPVLLVLTFLMEDWSSANIARNFPSTDRNGILFAMILSGLSSVFISYTSAWCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPVTFPSVSAIVVGFISGIVYAVAKIKQSAKPKTGVLPMSNPPVSASSQSMRDSLRS
What is the function of this protein?
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
What are the official names of this protein?
GDP-mannose transporter, GMT.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TRUB_PSEA6
Sequence: MARRRKGRAIDGILLLDKPLEISSNQALQKVKRAFLAAKAGHTGALDPLATGMLPVCLGEATKFSQFLLDADKTYIVTAKLGVRTTTSDADGEVVDTRQVNVTEQQLIDACETFKGPIKQVPSMFSALKHQGKPLYHYARQGIVIEREARDITIFSLKITRFEGDEVDMEVHCSKGTYIRSLVDDLGQLLGCCAYVSKLHRTAVADYPSDKMVTFEMLESLLEKAQAEQIPLTDILDPLLIPMDSAVKALPSVELTPASRDSFLHGQPVPYVSEATIDQGTLVRTYCTEGNVFLGVSELDSDNKAAPKRVVVFTEQG
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: JUPI1_RAT
Sequence: MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRKNKMASNIFGTPEENPPSWAKSAGGREDSESPGTQRSNSSEASSGDFLDLKGESDVHENVDTDFQASLAQVEEKPVPAAPVPSPVAPAPAPSRRNPPGGKSSLVLG
What is the function of this protein?
Modulates negatively AKT-mediated GSK3B signaling.  Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions.  Plays a role in the regulation of cell cycle and cell adhesion.  Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.
What are the official names of this protein?
Jupiter microtubule associated homolog 1, Hematological and neurological expressed 1 protein.
What is the protein family that this protein belongs to?
Belongs to the JUPITER family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RL33_CHLCV
Sequence: MASKNREIIKLKSSESSDMYWTVKNKRKTTGRLELKKYDRKLRRHVIFKEAK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.