PharMolix/UniProtQA huggingface dataset:
Protein: RNFD_SODGM
Sequence: MAFRIASSPFTHNRQTTRQIMIQVMLACLPGLMALTTFFGSGIIIQLVIACVTALVAEGVVLTLRRQPLASRLGDGSALLTALLLALSLPPLGPWWMMVLATAFAIVIAKQLYGGLGHNPFNPAMVGYVVLLISFPVQMTSWSPQQSLLLHPVSLTDSMALIFTGVTPDGLTLTQLRATVDGITQATPLDGFKTGLRTGAMTAFHHRWDWQASAGWTWANIGFLLGGLYLIWRRVISWHIPLSLLAAMLIGAGLGHWLAPVVSAPPLLHLFSGATMLGAFFIATDPVTAAATVRGRVIFGALTGLLVWLIRTWGGYPDGVAFAVLLANICVPLIDHYTQPRAYGHR
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CP24A_HUMAN
Sequence: MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
What is the function of this protein?
A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis.  Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:24893882, PubMed:15574355, PubMed:8679605, PubMed:11012668, PubMed:16617161, PubMed:29461981).  With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:24893882, PubMed:15574355).  With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product (PubMed:11012668, PubMed:8679605).  Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:8679605).
What are the official names of this protein?
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, 24-OHase, Vitamin D(3) 24-hydroxylase, Cytochrome P450 24A1, Cytochrome P450-CC24.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ALFL6_ORYSJ
Sequence: MEGGGGGGGGGGGGGGGGGGGGAPYATRTAEEVFRDLRGRRAGMIKALTTDVEKFYKLCDPEKENLCLYGYPNETWEVTLPAEEVPPEIPEPALGINFARDGMNEKDWLALVAVHSDSWLLSVAFYFGARFGFDREARRRLFNMINNLPTIFEVVTGAAKKQAKEKTPNSSSKSNKPSSKVQSKAESRSKSKLSAPKDEEGSGDDEGEEEEDDHDNTLCGTCGTNDGKDEFWICCDNCEKWYHGKCVKITPARAEHIKQYKCPDCTNKRARA
What is the function of this protein?
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
What are the official names of this protein?
PHD finger protein ALFIN-LIKE 6.
What is the protein family that this protein belongs to?
Belongs to the Alfin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MARR_ECOLI
Sequence: MKSTSDLFNEIIPLGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTGGAAICEQCHQLVGQDLHQELTKNLTADEVATLEYLLKKVLP
What is the function of this protein?
Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes.  Binds to the marO operator/promoter site.
What are the official names of this protein?
Multiple antibiotic resistance protein MarR.
Protein: IOLG_BURL3
Sequence: MTLQIGVIGCGAIGQDHIRRLTRTLSGARVVAVNDIDPQQARDAVTKYGLDAEIYGDGHEVVAAADVQAVLVTSWGPTHEAFVLDAIAHGKPVFCEKPLAVTAEGCMRIVEAEVAHGKRLVQVGFMRPYDEGYRALKRVIDSGEIGAPLMLHCAHRNQSVGERYTTDMAITDTLIHELDVLRWLLGEDYVSTQVVYPKKTRHASSHLADPQIVLLETASGVRIDVEIFVNCQYGYDIQCEVVGEQGIAKLPDPPAVGLKHGARQSVEIMTDWKERFIASYDVELQAFIDGVRAHALTGPSAWDGYAAAVAADACVRAQKSGAVEPIAMAERPAFYRG
What is the function of this protein?
Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
What are the official names of this protein?
Inositol 2-dehydrogenase, Myo-inositol 2-dehydrogenase, MI 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: SSRP_AGRRK
Sequence: MAPKGSQRVVKKIVAENRKARFNYEIIDTYEAGIVLMGTEVKSLREGKANIAESYASDEDGEIWLINSYLPEYLQANRFNHEPRRRRKLLLSGREIGRLRSGINREGMTLIPLKIYFNDNGRAKLELALAKGKKLHDKRQSEKERDWNRQKGRILKDNR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ISCS_RICAE
Sequence: MNPQLNNLTLPIYMDYQATTPIDPRVMEAMLPYFTTKFGNPHSRSHSFGWEAENAVEEARSMVAKLIGADTKEIIFTSGATESNNLAIKGIAKFYSNKKNHIITVVSEHKCVLDACRHLEQEGIKITYLPIKPNGIIDLETLKNAITDQTMLVSVMVVNNEIGVVQPLKEIGQICREKGVFFHSDIAQGFGKIPIDVNAFNIDLASISGHKIYGPKGIGALYVRKKPRVRVTPLINGGGQERGIRSGTLPTPLIVGLGMAAEIAYSEMEKDTKHINYLFDRFLNNIHKRISKVYLNGDKNQRYKGNLNLSFAGVEGESMILAIKDLAVSSGSACTSASLEPSYVLRSMGIGEELAHTAIRFGIGRFTTEQEVDYAVNLICSKIDKLRELSPLWEMMQEGIDLKKIKWAVH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OX2V_HHV6Z
Sequence: MSPLMLRLLPLLCIIISAHFVPRPETSPSLVYEIGSTVTFHCRLNTTTNIQSVSWYNKSRLISNHEIQNMDNLSFTDDGYVFIHELNKINNLDVDSKLYFHIKHDRTTSLLKIKARSAYDATCLTCTFTVDNEKTSATSCLKLIMKPIVVLYFRYLNNFLDVTCTVTSYPKPNVVIKFLGEVYKRDIPMVRQNENGSSTVSVSFTFKRRTKLEFVGKTISCLASSWFTNQKASALVTSGEHTVQNHDEYSKEAVKGSNSDETVFTWIVPLILILIISVMVLLISMCIVAFKS
What are the official names of this protein?
Putative OX-2 membrane glycoprotein homolog, Protein U85.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: RIBA_ECO5E
Sequence: MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: GLPK_STRPN
Sequence: MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAGWVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKKTGLPIYNAIVWQSRQTAPLAEQLKSQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEGAQERAEKGELLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAILPEVRSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYARDSHNNDEVYVVPAFTGLGAPYWNQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDIIDTMQVDTQTAIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGLSVGYWKDLDELKLLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEVDD
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: I11RB_MOUSE
Sequence: MSSSCSGLTRVLVAVATALVSSSSPCPQAWGPPGVQYGQPGRPVMLCCPGVSAGTPVSWFRDGDSRLLQGPDSGLGHRLVLAQVDSPDEGTYVCQTLDGVSGGMVTLKLGFPPARPEVSCQAVDYENFSCTWSPGQVSGLPTRYLTSYRKKTLPGAESQRESPSTGPWPCPQDPLEASRCVVHGAEFWSEYRINVTEVNPLGASTCLLDVRLQSILRPDPPQGLRVESVPGYPRRLHASWTYPASWRRQPHFLLKFRLQYRPAQHPAWSTVEPIGLEEVITDTVAGLPHAVRVSARDFLDAGTWSAWSPEAWGTPSTGLLQDEIPDWSQGHGQQLEAVVAQEDSLAPARPSLQPDPRPLDHRDPLEQVAVLASLGIFSCLGLAVGALALGLWLRLRRSGKEGPQKPGLLAPMIPVEKLPGIPNLQRTPENFS
What is the function of this protein?
Receptor for interleukin-11.  The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission.  The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.
What are the official names of this protein?
Interleukin-11 receptor subunit alpha-2, IL-11 receptor subunit alpha-2, IL-11R subunit alpha-2, IL-11R-alpha-2, IL-11RA2, Interleukin-11 receptor subunit beta, IL-11 receptor subunit beta, IL-11R subunit beta, IL-11R-beta, IL-11RB.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 3 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: XTH1_DIOKA
Sequence: MAFMSFINGFSTLFLVALLASSMMAAKGGNFYQDFDVTWGDHRAKIFNGGQLLSLSLDKTSGSGFRSKKEYLFGRIDMQLKLVAGNSAGTVTAYYLSSQGPTHDEIDFEFLGNLSGDPYIVHTNVFTQGKGNREQQFYLWFDPTRNFHTYSVVWNPRQIIFLIDNTPIRVFKNAESIGVPFPKNQPMRIYSSLWNADDWATRGGLVKTDWTKAPFTAYYRNFNAKTCSGACTESFGDGAWQSQELDAHSRRRLRWVQKNFMIYNYCTDLKRFPEGLPKECQRRSRFL
What is the function of this protein?
Catalyzes xyloglucan endotransglycosylation (XET).  Cleaves and religates xyloglucan polymers.  Does not catalyze xyloglucan endohydrolysis (XEH) (PubMed:25849978).  Overexpression in Arabidopsis transgenic plants results in elevated tolerance to abiotic stress, such as salt, ABA (abscisic acid) and drought stresses, and in the production of wider leaves.  Overexpression in transgenic tomato plants slows down fruit ripening and softening, and the plants produce larger fruits.  Both transgenic plants have larger and more irregular cells.  Moreover, the fruits of the transgenic tomato have higher density of cell wall and intercellular spaces.  May provide cells with more strength and thickness to maintain structural integrity (PubMed:28155115).  Probably involved in cell wall assembly and synthesis in fast growing tissues and in the maintenance of firmness in mature fruits (PubMed:25849978, PubMed:28155115).
What are the official names of this protein?
Xyloglucan endotransglucosylase protein 1, XET protein 1, DkXTH1, Xyloglucan endotransglucosylase/hydrolase protein 1, XTH protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family. XTH group 2 subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted, extracellular space, apoplast.
Protein: M28P2_PYRTT
Sequence: MLFRSVILSNALLLPACAHDILSNLDLSLPIAANAESYTDCANAAWPPSNVGVELVPQPPDDQLRAMVDEVSAENIEATITKLVSFGTRHTLSTFNSSTRGINAARDWIASEMRKYAAESNGTMTVEVQSYVQSVASRIPFPVTISNVLAKATGSEDPNRVYVMTGHYDSRVTDVLNYESDAPGANDDASGTAIAMELARVLAKHQPKSTIILGAVAGEEQGLYGSTYLAQTLKNTSTNVEGMLNCDIVGSSTGDRGQKDPFTIRAFAQGPPPISAESSARAAQRLQIGGENDSPARELARFSAEVAANNATGMNVAIIYRLDRFLRGGDHTGFLQAGYPAIRYTEPNENFAHQHQDIRTENGTVYGDLIEFVDFDFTARVGKVNLATLWSLAQAPAMPRNVTIDATILDNNSRIKWIVSNKTDVASYEVVWRSTIASLWTHMLDVGKVGYVVLPLSKDNVIFGIRAVGTNGFKSPAVYPFPA
What are the official names of this protein?
Probable zinc metalloprotease PTT_08196.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOC_PSEPK
Sequence: MKDLLNLLKNQGQVEEFDAIRIGLASPEMIRSWSFGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVALAKVRRERMAHIELASPVAHIWFLKSLPSRIGLLMDMTLRDIERVLYFESYVVIDPGMTTLEKGQLLNDEQYFEALEEFGDDFDARMGAEAVRELLHAIDLEHEIGRLREEIPQTNSETKIKKLSKRLKLMEAFQGSGNLPEWMVLTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLSAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPTLRLHQCGLPKKMALELFKPFIFGKLEMRGLATTIKAAKKMVERELPEVWDVLAEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTREAINAKGEGRVFADLQEVDRVFRAGEAALHAKIKVRINETVKERDGSVVKNTRIVDTTVGRALLFQVVPAGLPYDVVNQPMKKKAISKLINQCYRVVGLKETVIFADQLMYTGFAYSTISGVSIGVNDFVIPDEKARIIGNATDEVKEIESQYASGLVTQGEKYNKVIDLWSKANDEVSKAMMANLSKEKVIDREGKEVEQESFNSMYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLSVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEIDCGTDQGLVMTPHIEGGDVVEPLGERVLGRVIARDVFKPGTEDVIVPAGTLVDEQWVEFIELNSIDEVIVRSPINCETRYGICAKCYGRDLARGHQVNIGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRTSAADSVQVKNGGMVRLHNLKQVERADGNLVAVSRSGELAIADEFGRERERYKLPYGAVISVKEGEKVEAGAIVAKWDPHTHPIVTELKGTVTFVGMEENITIKRQTDELTGLTNIEVLDVKDRPAAGKEIRPAIKMVDAAGKDLYLPGTDVPAQYFLPANALVGVADGAQIGVGDVIARIPQETSKTRDITGGLPRVADLFEARRPKEASILAEVSGTIAFGKETKGKRRLVITPTDGSEPYEELIPKWRHLNVFEGEQVNRGEVISDGPSDPHDILRLLGVSALAKYIVNEIQDVYRLQGVKINDKHIETILRQMLRKVEISESGDSSFIKGDQMELTQVLVENERLASEDKFISKFTRVLLGITKASLSTESFISAASFQETTRVLTEAAVTGKRDYLRGLKENVVVGRLIPAGTGLAYHSERKRRRDADKPLRVSASEVEAALTEALNSSGN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: ENO_STAAN
Sequence: MPIITDVYAREVLDSRGNPTVEVEVLTESGAFGRALVPSGASTGEHEAVELRDGDKSRYLGKGVTKAVENVNEIIAPEIIEGEFSVLDQVSIDKMMIALDGTPNKGKLGANAILGVSIAVARAAADLLGQPLYKYLGGFNGKQLPVPMMNIVNGGSHSDAPIAFQEFMILPVGATTFKESLRWGTEIFHNLKSILSKRGLETAVGDEGGFAPKFEGTEDAVETIIQAIEAAGYKPGEEVFLGFDCASSEFYENGVYDYSKFEGEHGAKRTAAEQVDYLEQLVDKYPIITIEDGMDENDWDGWKQLTERIGDRVQLVGDDLFVTNTEILAKGIENGIGNSILIKVNQIGTLTETFDAIEMAQKAGYTAVVSHRSGETEDTTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDELFETAKYDGIKSFYNLDK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: SYP_DESDA
Sequence: MRFSSCYIPTLKESPADAEVISHKLLLRAGMVRRLTSGLYIYLPLGLRVINKIARTVREEMEKAGFRELLMPMVQPGDLWKETGRWEHYGKELLRFKDRNEREYCLGPTHEEVITDLVRGEVRSYRQLPVRLYQVQTKFRDEIRPRFGLMRGREFMMKDGYSFDATAEGAEESYKIMYDAYMSIFSRLGLRFRAVEADTGSIGGNFSHEFMVLADTGEDTIAFCHDCEYAANVERAEVAWRGSPSTGGCPAMEKIATPGAHSVEELTALLGVPASAIVKTMLFKVDGKTVAVLVRGDREVNDIKLKNLLKAQEVELADAATVQAVTAAPVGFAGPVALDVPVYADAELQGGTDYVVGANAADAHLKHVDLARDAAVTAWADLRAITADDQCPRCGGRMELTRGIEVGHIFMLGLKYSEAMHAVFLDENGKERTMIMGCYGIGVSRVAAAAIEQNHDEHGIVFPPPVAPFECVLLNLDPRSEEVNAKVEEIYALLQGMGIEVLLDDREERPGVKFKDADLLGIPMQLVVGGKGLGRGIVECKDRRTGEKGELSAASLEQDFAAWSEKVRQGWASR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KEX1_CANTT
Sequence: MLLSVFIILINTLFVLAIPPKEGSDNNPSKKYLVTDLPGLYENVKPKISVPLMFSGQLELYPENNTHYFFWKFVDSELNQDTSKKTIFWLNGGPGCSSMDGALLETGPFRIDENEKVIYNNGSWHKFGDIIYVDQPAGTGFSFTNEYITDLDQVAWYFLKFMEEYYKLFPNEINNEIYFAGESYAGQYIPYIADAILKRNKNLKENDVKYDLKGILIGNGWVSPNQQSLSYLPFFINHGLIDKSHPRWGSLLSKHEKCQKIVNKIDGHFDEADVHPYEVNSATCESILTDLLNYSQDRESDSDHRCINMYDYTLRDSYPSCGMNWPFELKYVAPFLRKEEVMHDLNLVDLKYWRECSGKVGRMFGARNSLPAVHLLPNISQEIPIILFNGANDIICNSDGVLSYLDKLQWGGKVGFTNKDDQINWIYDNKEVGYILMERNISFINIYNSSHMVPYDLPDVSRALMDLVSGKYEEKEKDGKREFITYPLGEVRNKLGQEIPADESSKPIEDKPDDKPIEDKPEETKPEQTKPEDETSSSTSEIIPTSEASFIPEPEESTSSKFTRLIQLGVIFIIFWGVYILYVSYRARPSSIIKKPARSTNSSGRKKNVQWADQLNRFEEDENELGSPPPQGIIAKTISKITGNTSNRGRYAPAGDGSREFTDDIELGEGISDPNVDEFIIGSDDDEDDDEDVETHEGNPKKTESKS
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase KEX1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: UGT58_CAEEL
Sequence: MKSWLLLLGTIGWVTAGDVLFIPSTLYPVHAQTMSVLARELAERGHKVTWLEIGPERSDIVLHQQVSREFWPAQFGDRTLQEIYQFKNHTSHSELWNPQYTNENEQTTGWLASIRLCDSVLSRSKSKFDKMVEKQFSTVIVDDLYNSCGVLMAGLKKSVYIYWSMTGLRTESAWANQSPSPPSYLPVAGTGLTDDLTFSQRLYNVASYFKQLYIHQHIVQPRIDAVFQKYYPGVESTFEIERNASINFVNTPPIFDFSRPYMPRVNFIGAIQCRKPKELPKEFTSWISAYPDGFVVLSTGFTVQWNKSPEHIRQAYLDTFKYLPNLLFIWQTGLPNSSNLPSNLLVKPWLPLQDLLGHQKCRCHVSHGGLNSVIESVYHGVPVVGVPLTSRGYDNLLRITARDSGVMVEKSEFSGEILTAAINEVIENEKYKKEMLIFQDMVIDVPYTELYHAAFWVEFIERHQEVPHARSGADHLNFLQYFLVDVIAFFFFVIFCTLSIIYYTIRTVFRTIRSVVNGVRGVPKIVSRGKKNN
What are the official names of this protein?
Putative UDP-glucuronosyltransferase ugt-58, UDPGT 58.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YOHJ_SALEP
Sequence: MSKSLNIIWQYIRAFVLIYACLYAGIFLASLLPITIPGSIIGMLILFVLLALQILPAKWVNPGCYVLIRYMALLFVPIGVGVMQYFDLLRAQFGPVVVSCAISTLVVFVVVSWSSHLIHGERKVVGQKGTKK
What are the official names of this protein?
UPF0299 membrane protein YohJ.
What is the protein family that this protein belongs to?
Belongs to the UPF0299 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TIMP1_PAPCY
Sequence: MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRTRIA
What is the function of this protein?
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor.  Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16.  Does not act on MMP14.  Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1.  Plays a role in integrin signaling.
What are the official names of this protein?
Metalloproteinase inhibitor 1, Tissue inhibitor of metalloproteinases 1, TIMP-1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I35 (TIMP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CCRM_CAUVN
Sequence: MKFGPETIIHGDCIEQMNALPEKSVDLIFADPPYNLQLGGDLLRPDNSKVDAVDDHWDQFESFAAYDKFTREWLKAARRVLKDDGAIWVIGSYHNIFRVGVAVQDLGFWILNDIVWRKSNPMPNFKGTRFANAHETLIWASKSQNAKRYTFNYDALKMANDEVQMRSDWTIPLCTGEERIKGADGQKAHPTQKPEALLYRVILSTTKPGDVILDPFFGVGTTGAAAKRLGRKFIGIEREAEYLEHAKARIAKVVPIAPEDLDVMGSKRAEPRVPFGTIVEAGLLSPGDTLYCSKGTHVAKVRPDGSITVGDLSGSIHKIGALVQSAPACNGWTYWHFKTDAGLAPIDVLRAQVRAGMN
What is the function of this protein?
A beta subtype methylase that recognizes the double-stranded sequence 5'-GANTC-3' and methylates non-modifed A-2 on the hemimethylated, post-replicative DNA (PubMed:12654995) (Probable).  Functions only in the predivisional cell.  Responsible for 5'-GANTC-3' methylation in the cell; remethylation of hemimethylated sites generated after replication fork passage occurs late in the predivisional cell, near completion of chromosome replication but prior to cell division.  Constitutive expression of the methylase leads to morphologically aberrant cells as well as cells that have undergone additional chromosome replication.  Contributes to the accurate cell-cycle control of DNA replication and cellular morphology (PubMed:8289276, PubMed:8577742).  Opens a bubble in the DNA at the recognition site, allowing precise recognition of the sequence and ensuring enzyme specificity (By similarity).  Can fully replace its ortholog in R. meliloti (PubMed:9294447).
What are the official names of this protein?
DNA methyltransferase CcrM, M.CcrMI, Adenine-specific methyltransferase CcrMI, Type II methyltransferase M.CcrNAI, M.CcrNAI.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: ALNR_EMENI
Sequence: MSTVNQSSTRSELAGNWERLRKSCDTCQEAKVKCSQHKPSCHRCLRHRQPCVYSPQRRSGRPPKRPSPSSRLGPESNNSGDDIHNENTIQRTNLNANDSAMTDAGAVDPRVLTGDFAASTGIDPVDDIFQTSFESFLAASLSPKGGLLPGSHSNPTTPNGFSMNSPSITDPFGAFPFLITDHNLPIAALSSHVPPIDQLPVLSTGASNTSSECGDCGAKCYSSLLQHLLFLRQTLPESTRPSIDVIMQAEGHVRALLDRVLGCNACLGNRSSILLISAITERIVQMLDWIIEEKTLLDTENMRYNRRTFSSWGRPPRLPPHGLNGMRRNVCHVSLRVGNTELDEDAKQYFLKNFILLRLKKLAVKVQEVRRTATTRPGDCIYRAAELVLADSIQRLDYLRGQCQLWE
What is the function of this protein?
Transcriptional regulator involved in the positive regulation of the expression of the gene cluster that mediates the biosynthesis of asperlin, a polyketide showing anti-inflammatory, antitumor and antibiotic activities.
What are the official names of this protein?
Transcriptional regulator alnR, Asperlin biosynthesis cluster protein R.
What are the subcellular locations of this protein?
Nucleus.