PharMolix/UniProtQA huggingface dataset:
Protein: GLNE_ALTMD
Sequence: MPTDNENSMTNVEQAEKYWQQFLTAPALTDDDKAIAKQHHDVLLTAFARSSFLAETIIQKPSFVSRTVEQTVEQTVEQTTEQDSDEQLQKNVDKEASSPWVAMYRSALDITLETVKTEDDLLKALREYRNQEMARVTFLDVLNKQDISTSLERVSALADVLLTGAYHWIYQHLAIRYGTPQNNGEDMHMYILGMGKLGGKELNFSSDIDLIFSYPEKGETQGGRKSIEHQQFFTKLAQKLIQALNKITNDGQVYRVDMRLRPFGDSGPLVMHFAALEDYYQDQGRHWERFAMVKARVINDDNSEDVKWLNSILHPFTFRRYLDFTTLDALRNMKKLIATEIRRRRLNNNIKLGAGGIREVEFFAQSFQLIHGGREPALQSKSLLRTLDALTELDIVEKDVTEQLKHDYLFLRKVEHTLQQCQDRQTQTLPDSAWQQAALIEVMGFDSYSTFLNQLDATMARIHGHFNELVEESQDSHSDEDQLFIACQDAWRLSLQEEEFAETFSEHLSSKDITGVYPILVAFKDKQRNYRIGQKGEDTLNKLLPEILYVLINQHPNHISQVLKRLLGVIEAITGRTTYLDLLLENPDVLKQLVKLCERSDWIAQEIKRFPLLLDELLTPLYLGQQNTDIHTSKKEYQLELRETMLRIEQDDVEMLMDGLRQFKLCQQLRIAASDISESLPVNNVSDKLTVLAEVILEHVVNAAWMQMRQRYGVPSHLEGNDKGFAVIGYGKLGGYELGYGSDLDLVFLHNAPRGISTDGNKSLEAQQFYIKLAQRIMHLLNTKTLFGQLYETDLRLRPSGNAGLLCCHIDGFEKYQTEEAWTWEHQALVRARAICGDVGLLKDFTRVRHTILSQVRDSKSLATDVCKMRLKMREHLLSKNNDKVDLKQCVGGITDIEFMAQYLVLANAQSADSMTTYPDNLRIFDTAVKARIIDPSTASKLQKAYLKLREQYHHLTLADTKYADQSEELDAIREQVRQHWDTLFGTCSE
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: STPA_SHIFL
Sequence: MSVMLQSLNNIRTLRAMAREFSIDVLEEMLEKFRVVTKERREEEEQQQRELAERQEKISTWLELMKADGINPEELLGNSSAAAPRAGKKRQPRPAKYKFTDVNGETKTWTGQGRTPKPIAQALAEGKSLDDFLI
What is the function of this protein?
A DNA-binding protein that acts in a fashion similar to H-NS, repressing gene transcription.  A subset of H-NS/StpA-regulated genes require auxillary proteins for repression; these auxillary proteins (Hha and other similar proteins) may also modulate oligomerization of the H-NS/StpA complex (By similarity).
What are the official names of this protein?
DNA-binding protein StpA, H-NS homolog StpA.
What is the protein family that this protein belongs to?
Belongs to the histone-like protein H-NS family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SECA_CROS8
Sequence: MLIKMLTKVFGSRNDRTLRRMRKVVALINGMEPALEKLSDEELKAKTAEFRARLEKGETLENLLPEAFAVVREASKRVFGMRHFDVQLLGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGMSVAVNMSGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSELYKKVNKIIPHLVRQEKEDSDTFQGEGHFSVDEKARQVNLTERGLVLVEELLVKEGIMDEGESLYSPGNIMLMHHVTAALRAHVLFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIDAIIEDIKERTAKGQPVLVGTISIEKSEVISQALTKAGIEHNVLNAKFHAREADIVAQAGYPGAVTIATNMAGRGTDIMLGGSWQAEVAELEAPSEEQIAQIKADWQKRHDAVLASGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSMEDALMRIFASDRVANMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYTQRNELLDVADISETINSIREDVFKATIDAHIPPQSLEEMWDIPGLEERLKNDFDLELPIAQWLDKEPELHEETLRERILESAKEVYARKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFAMFAAMLESLKYEVISTISKVQVRMPEEVEAMEQQRREEAERLAQMQQLSHQDDETAAAAALAEQTGERKVGRNDPCPCGSGKKYKQCHGRLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: RNPH_PROMM
Sequence: MLTSPQPRADGRLADVMRPLQITWDPMGFALSSLIIRTGRTSVLCSVCVEEGVPRWRKGQGKGWLSAEYRLLPGSTPQRQNRELLKLSGRTQEIQRLIGRSLRAVIDMAALGETTLRIDCDVIQADAGTRTASITGAWIALKRGCDRLLEQGLLTHQPVIEQVAAVSVGLVESYPLLDLDYSEDSRADVDLNVVMGSNGHLLELQGTAEGAPFSRNQLNDLLNLAEPGLQHLQAFQRSALMQED
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: Y2355_BACLD
Sequence: MKVLAVTGYKPFELGIFKHDDKALFYIKKALENRMIALLEEGLEWVLISGQLGTELWAAEVAFSLQEEFPDLKVAVITPFLEQEKKWSEKNQEQYEAVLAASDFTESLTHRPYESPVQFKQKNRFFIEKADGLLILYDEEIEGSPVYMLNEAKKAQEKRDFPIYTITMDDLRVTVEECSFYEE
What are the official names of this protein?
UPF0398 protein BLi02355/BL05236.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: MFD_ECOLI
Sequence: MPEQYRYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQNALRLHDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPTMQRGVLIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGYRHVDQVMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQRTLEEVEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSKGTLPAGIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTLARFENRGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAANANLGFQKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGELLARIKIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLLGERVARRRQDSRRTINPDTLIRNLAELHIGQPVVHLEHGVGRYAGMTTLEAGGITGEYLMLTYANDAKLYVPVSSLHLISRYAGGAEENAPLHKLGGDAWSRARQKAAEKVRDVAAELLDIYAQRAAKEGFAFKHDREQYQLFCDSFPFETTPDQAQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAVDNHKQVAVLVPTTLLAQQHYDNFRDRFANWPVRIEMISRFRSAKEQTQILAEVAEGKIDILIGTHKLLQSDVKFKDLGLLIVDEEHRFGVRHKERIKAMRANVDILTLTATPIPRTLNMAMSGMRDLSIIATPPARRLAVKTFVREYDSMVVREAILREILRGGQVYYLYNDVENIQKAAERLAELVPEARIAIGHGQMRERELERVMNDFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLRGRVGRSHHQAYAWLLTPHPKAMTTDAQKRLEAIASLEDLGAGFALATHDLEIRGAGELLGEEQSGSMETIGFSLYMELLENAVDALKAGREPSLEDLTSQQTEVELRMPSLLPDDFIPDVNTRLSFYKRIASAKTENELEEIKVELIDRFGLLPDPARTLLDIARLRQQAQKLGIRKLEGNEKGGVIEFAEKNHVNPAWLIGLLQKQPQHYRLDGPTRLKFIQDLSERKTRIEWVRQFMRELEENAIA
What is the function of this protein?
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions.  Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.  Can also dissociate RNAP that is blocked by low concentration of nucleoside triphosphates or by physical obstruction, such as bound proteins.  In addition, can rescue arrested complexes by promoting forward translocation.  Has ATPase activity, which is required for removal of stalled RNAP, but seems to lack helicase activity.  May act through a translocase activity that rewinds upstream DNA, leading either to translocation or to release of RNAP when the enzyme active site cannot continue elongation.
What are the official names of this protein?
Transcription-repair-coupling factor, TRCF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the helicase family. RecG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y683_MYCPN
Sequence: MKDTEKKTEKELVWDECVDILENVKANSFKATLEYYLASDKKTKKAKPAKVKKVKEPKAKAVKPEQVKPTKTTKAPKPKKPKKQGGLISQWKEKLEAPYRTPYVEQKQGMVISIDKMWKHVHGEDSKEQIAILSDVSLEIGYGEIVIILGPSGSGKTTLLNLIGGYDSISLGSCVVANCPLEKCTTEQLLTYRKLNLGYVYQRYNLIELLSAYDNIAISQNLIPKEQRHLDIEELAAKLDIKEILYKFPYEMSGGQKQRVAIARAIIKEPRLLLCDEPTGALDSNSAENIIALLQAINKEYKQTILMVTHDETLTRIANRIIKISDGKIVSNELVRPLS
What are the official names of this protein?
Putative ABC transporter ATP-binding protein MG467 homolog.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: MNMA_NEIG1
Sequence: MNTTSNTSNIIVGLSGGVDSSVTAALLKQQGYQVRGVFMQNWENDDNDEYCSIKQDSFDAIAVADIVGIDIDIVNFAAQYKDKVFAYFLQEYSAGRTPNPDVLCNAEIKFKCFLDYAVGQGADTIATGHYARKEARNGVHYLLKGLDRNKDQSYFLYRLKPFQLERAIFPLGGLEKPEVRRLAAEFNLPTAAKKDSTGICFIGERPFREFLQKYLPTDNGKMVTPEGKTIGEHVGLMFYTLGQRKGLGIGGAGEPWFVAAKDLTKNELIVVQGHDHPLLYTRSLVMNDLSFTLPERPKAGRYTCKTRYRMADAPCELCYLDDETAELVFDEPQWAVTPGQSAVLYDVDICLGGGIIQTTDKPVIITR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2117_HYPNA
Sequence: MLLHIPEVLNGQELATLRETLAGADWQDGAATAGAQAVRVKQNLQLPAGAPDARPMGELVKAALLRHPLFQSAALPHTVLTPRFNRYEGGGHYGNHVDSAIHADPFLGVSVRTDVSTTVFLNDPEDYDGGELIVEDTYGVHEVKLPAGDAILYPATSLHRVESVTRGTRLASFLWTQSRVRDDARRGMLFQLDMTILSLRGKLADAPEVVALTGHYHNLLRQWADA
What are the official names of this protein?
PKHD-type hydroxylase HNE_2117.
Protein: RS12_THEVB
Sequence: MPTIQQLIRQERELLKRKTKSPALKGCPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGTLDTAGVKDRKQGRSKYGAKRPKPGEAAATGKKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: Y2354_DICDI
Sequence: MQNIGFAAGSLIKGRWTVVKKIGQGAFGEIFSGKNIINNEQIAIKVEKVDTKKQVLRLEVAVLKKLQLCPYVCRFITCGRHNDYNYMVMELLGENLSELRRKQLDGKFSLGSTLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKRNITYLIDFGLARRFVLASGEVRPARESTGFRGTARYASINSHLSKDLGRRDDLWSIFYVLIEFAEGQLPWRKLKDKDQIGEMKQKYNTPDLVKDLPPQFSQFMKHLKSLNYEDRPNYVFLQTLLNDCYTSLGLSESTPFDWEVQTNSGASSSSSNTTQQQQQQQQQQQQRNLNQSGLNNSSARLMASPSTIDVEASGKSTQLNNSNNNNNNNNKGLGAENDSSPQPQIIRRNSESNSQIANSSESDNKGSGGGSWNQKSSSPRHKDKNLQDDGGEGSQKHLKASNNNNINNNNNNYNNNNNNNNNSHMNGNGSNSQPIDKIELSHQQQKSSTTKCCSTSKCSVM
What are the official names of this protein?
Probable serine/threonine-protein kinase DDB_G0292354.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
Protein: MIAA_CERS1
Sequence: MAEEPQRSPAPTSPFAFTVPSNPLSDLPDIPSDRPVLIAGPTASGKSALAARLVEDGGGVVVNADALQVYDCWRLLSARPSAAEEAALPHRLYGHVGARQTYSAGHWLKEVAAVLAEGLRPVIVGGTGLYFSALTEGLAEIPHTPPEVRAEADARLAEAGLARMVAELDAETAARIDLQNPARVQRAWEVLRATGRGLARWQAETAPPLLPLSDATALVIRPDPAWLAQRIDSRFDLMMADGALDEVRATLPGWDPALPSARAIGAPELVAHLRGEIPLDEAIAAAKLASRQYAKRQRTWFRNRMRLWHEIRLP
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RL7_FUSNN
Sequence: MAFNKEQFIADLEAMTVLELKELVSALEEHFGVTAAAPVAVAAAGGATEAAEEKTEFDVVLKSAGGNKIAVIKEVRAITGLGLKEAKDLVDNGGVIKEAAPKDEANAIKEKLTAAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: Y1056_STRP1
Sequence: MSTHLRKLPGLLLCLLLALPAWCLGRLFPIIGAPVFAILLGMLLALFYEHRDKTKEGISFTSKYILQTAVVLLGFGLNLTQVMAVGMQSLPIIISTIATALLVAYGLQKWLRLDVNTATLVGVGSSICGGSAVAATAPVIKAKDDEVAKAISVIFLFNMLAALLFPSLGQLLGLSNEGFAIFAGTAVNDTSSVTATATAWDALHHSNTLDGATIVKLTRTLAILPITLGLSLYRAKKEHDIVTEENFSLRKSFPRFILFFLLASLITTLMTSLGVSADSFHYLKTLSKFFIVMAMAAIGLNTNLVKLIKTGGQAILLGAICWVAITLVSLAMQLSLGIW
What are the official names of this protein?
UPF0324 membrane protein SPy_1056/M5005_Spy0779.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CLCA_ECOUT
Sequence: MKTDTPSLETPQAARLRRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDVFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQLARSKAASARENT
What is the function of this protein?
Proton-coupled chloride transporter.  Functions as antiport system and exchanges two chloride ions for 1 proton.  Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
H(+)/Cl(-) exchange transporter ClcA.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATP6_COXBU
Sequence: MYAQPKLTSAEYVQHHMSHWKLNLHNFTFTDGGFWTLNLDTLIISVVLGALFILIFYIVARRATASVPGKWQNAIEMAVEAVDGTVKDSFHGDRSLVAPLALTIFIWVFLMNFMDLVPVDLIPRLFQMGGVEHFKAVPTADPTLTFAMSITVFVLVIFYNFKMKGAIGLGKEVLSRPFGWYLMPINVIFRLIDEGVKPISLALRLFGNLFAGELIFILIALLPWWSQFTLGMVWTLFHLLVITVQAFIFMMLTVVYISLAAESH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YEIS_ECO57
Sequence: MDVQQFFVVAVFFLIPIFCFREAWKGWRAGAIDKRVKNAPEPVYVWRAKNPGLFFAYMVAYIGFGILSIGMIVYLIFYR
What are the official names of this protein?
Uncharacterized protein YeiS.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HRCA_STAAM
Sequence: MITDRQLSILNAIVEDYVDFGQPVGSKTLIERHNLNVSPATIRNEMKQLEDLNYIEKTHSSSGRSPSQLGFRYYVNRLLEQTSHQKTNKLRRLNQLLVENQYDVSSALTYFADELSNISQYTTLVVHPNHKQDIINNVHLIRANPNLVIMVIVFSSGHVEHVHLASDIPFSNDKLNTISNFVTNKLTEFNQNLQDDIVSFVQSEQEEIFINKLINTMNNHISNQSNSIYMGGKVKLIDALNESNVSSIQPILQYIESNRIAELLQDISSPNINVKIGNEIDDSLSDISIVTSQYHFDETLKGQIAVIGPTAMHYQNVIQLLNRIW
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: COA3_HUMAN
Sequence: MASSGAGDPLDSKRGEAPFAQRIDPTREKLTPEQLHSMRQAELAQWQKVLPRRRTRNIVTGLGIGALVLAIYGYTFYSISQERFLDELEDEAKAARARALARASGS
What is the function of this protein?
Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.  MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion.  Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
What are the official names of this protein?
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial, Coiled-coil domain-containing protein 56, Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa.
What is the protein family that this protein belongs to?
Belongs to the COA3 family.
Protein: PG073_VACCC
Sequence: MELVNIFLETDAGRVKFAIKNTDDVCASELINKFVELLSEYIHIDQSEFYLVVKDKDIFYFKCDRGSISIVNNEFYVFDEPLLFVKDFTNVTGVEFIVTETMPCRIIPKNNHAVISVVTNHKFYNGLSL
What are the official names of this protein?
Core protein OPG073, Protein E11.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG073 family.
Protein: RAD25_SCHPO
Sequence: MSNSRENSVYLAKLAEQAERYEEMVENMKKVACSNDKLSVEERNLLSVAYKNIIGARRASWRIISSIEQKEESRGNTRQAALIKEYRKKIEDELSDICHDVLSVLEKHLIPAATTGESKVFYYKMKGDYYRYLAEFTVGEVCKEAADSSLEAYKAASDIAVAELPPTDPMRLGLALNFSVFYYEILDSPESACHLAKQVFDEAISELDSLSEESYKDSTLIMQLLRDNLTLWTSDAEYNQSAKEEAPAAAAASENEHPEPKESTTDTVKA
What is the function of this protein?
Acts in cell cycle and stress checkpoint signaling by sequestering signal transducers regulated by the checkpoints (By similarity).  Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted (PubMed:8036497).  Sequesters byr2 in the cytoplasm to prevent its translocation to the plasma membrane (PubMed:12242289).
What are the official names of this protein?
Checkpoint signal transducer rad25.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_PSEAB
Sequence: MDFPTRFDVIVIGGGHAGTEAALAAARMGVKTLLLTHNVETLGQMSCNPAIGGIGKSHLVKEIDALGGAMAEATDKGGIQFRILNSRKGPAVRATRAQADRVLYKAAIRHTLENQPNLWIFQQACDDLIVEQDQVRGVVTQMGLRFHADNVVLTTGTFLGGLIHIGLENYSGGRAGDPPSIALARRLRELPLRVGRLKTGTPPRIDGRSVDFSVMTEQPGDTPIPVMSFLGSKEQHPEQVSCWITHTNARTHEIIAANLDRSPMYSGVIEGIGPRYCPSIEDKIHRFADKESHQVFLEPEGLTTHELYPNGISTSLPFDVQLQIVRSIRGMENAHIVRPGYAIEYDFFDPRDLRYSLETKVIGGLFFAGQINGTTGYEEAGAQGLLAGANAALRSQGKDSWCPRRDEAYIGVLVDDLITLGTQEPYRMFTSRAEYRLILREDNADLRLTEKGRELGLVDDRRWAAFEAKREGIEREEQRLKSTWVRPNTPQGDAIAERFGTPLTHEYNLLNLLSRPEIDYAGLVEITGDAVDNPQVAEQVEIRTKYAGYIDRQQEEIARLRASEDTRLPVDIDYLGISGLSKEIQNKLNQARPETLGQASRIPGVTPAAISLLLIHLKKRASGRQLEQSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XRN2_YARLI
Sequence: MGVPGLYRHLSQKCPKIVSDVIEDETTIVDGEEIPGSDYSAPNPNGELDNLYLDMNGIVHPCTHPEGEEAPPSEDEMLLAVFKYTERVLNVCRPRKVLMMAIDGVAPRAKMNQQRARRFRSAKDAAIEAESTLESELKAKTIELQSSGEKGKSLETILDEFKQGLVNKPGKWDSNAITPGTPFMEKLAAALRYWVGYKLNTEPGWRDLKVVISDATVPGEGEHKIMEFIRSQRGDPTYNANTSHCIYGLDADLIFLGLATHEPKFKLLREDVFRQNKTAGHQKKPFIWLNIDILREYLREDLRFTHPQTKIPFDLERAIDDWVFLCFFVGNDFLPHLPACDVRDGSINVLVNQWKNGMTRWKDYITCDGHVNLAQAQDLLKNFATQEQRILVHQEQDRVEYEKSQANKAAKQQAHRDSKKLRQQGEQAALESMPLYDTKGESVGDVQLTNRELVGQRNDITLANLANQDAADKLRFMLKRGSDTGAEEPAKRAKIEEEPKEAESNSSEATPPTANPSIANDADLSNPNVTVHETTGYADHVQFHKSGYTERYYMNKFHAKEDEVDNLRRQVAEEYMKGVCWVLMYYYHGCQSWSWFYPYHYAPLAGDFDQISNMKVEFGESAPFRPYEQLMSVLPAASGHNLPAVFRPLMSEENSPIIDYYPENFQLDLNGKKQEWKAVVLLPFINADHLLEHVQAKYTELTPEEKDRNTLREEIVIFHRLGKYAKTLEKRGLMEKGVIVSKKPLVLNSHETSGLAGTVERQNEADRTSSKPHLTFPLNVSTDQTMPSFEADKNMAMTLEYKIPKLEYENKSMLLQGYIPPKYTLSDEEREAIRNRERQRRGGQQDSRLFSNTDHRQQQELLMNGSYLAFKKLSLRDQPPPAKEDWMLNDPKLAGDRGNGGYNNRGGFNNHRGGRGGFNNRGRGGFNHGGGGFNNSRGGYGGGGGGYGGGGGQGYGGGQGYGGGQGYGGGQGYGGGGYGGGQGYGGGGYGGGYGGGHRGGHRGGRGGHRY
What is the function of this protein?
Possesses 5'->3' exoribonuclease activity.  Required for the processing of nuclear mRNA and rRNA precursors.  May promote termination of transcription by RNA polymerase II (By similarity).
What are the official names of this protein?
5'-3' exoribonuclease 2.
What is the protein family that this protein belongs to?
Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL34_RICPU
Sequence: MKRTFQPSNLVRKRRHGFRSRMATPTGRAILRKRRAKGRHKLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: HRCA_ROSS1
Sequence: MTTDLTDRRRLILKLAIQEFIESSQPVASDLLVRKYRLNVSPATVRNELAALEELGYLTHLHTSAGRVPTDAGYRYFVENLMDRTPLSATEQRTIRHQFYQVRSELDQWIQLAGAVLARTAQNASVVTPPRAQQARLKHLELIAIHETTALMVLVLHDGTIRQQTLTLDVAMTQEELSRCAAQINERCCDAPVERIEEVLKQERAQEPPGGNALVCQVLDLVVKAMHQFNEHISSDIHSDGLIEILNQPEFSRVERVRRMVEILQSGRALGTLIPRALSSSGVQVVIGGEHSYDEMREYSVVLSRYGGGEIVGVLGVIGPTRMAYPRAISAVRYISAVMSDLLAELYGIEGANRLNSEP
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: UD11_RAT
Sequence: MSVVCRSSCSLLLLPCLLLCVLGPSASHAGKLLVIPIDGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSSMLLSGCSHLLHNAEFMASLEQSHFDALLTDPFLPCGSIVAQYLSLPAVYFLNALPCSLDLEATQCPAPLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVYSPYGSLATEILQKEVTVKDLLSPASIWLMRNDFVKDYPRPIMPNMVFIGGINCLQKKALSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH
What is the function of this protein?
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:8554318).  Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:8554318).  Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (By similarity).  Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (By similarity).  Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (By similarity).  Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (By similarity).  Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (By similarity).
What are the official names of this protein?
UDP-glucuronosyltransferase 1A1, UGT1A1, B1, UDP-glucuronosyltransferase 1-1, UDPGT 1-1, UGT1*1, UGT1-01, UGT1.1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.