PharMolix/UniProtQA huggingface dataset:
Protein: FACE2_MOUSE
Sequence: MAALGGDGLRLLSVSRPERQPESAALSGPGSGLCCWVSVFSCFSLACSYVGSLYVWKSELPRDHPAVIKRRSTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLTDGLKVVLAPRSWARCLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCTGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGSIFVSAAFQFSYTAVFGAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAALEHPQKWPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCMLLERTGASETLLCS
What is the function of this protein?
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins.  Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity).
What are the official names of this protein?
CAAX prenyl protease 2, Farnesylated proteins-converting enzyme 2, FACE-2, Prenyl protein-specific endoprotease 2, RCE1 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase U48 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LACT2_CAEEL
Sequence: MDAMEDKGETEAENVVKLETGSSRRLLIYGIASILAVSGAWLVVATTVDSLACFIEGEMHLDNLVGHVAPGYEKVEKVFRRNFADGWEREGASITVYHKDRVIVDLQGGYADKASGRKWTPDTRTVVFSTTKAVGAVCVAMLVDRGHISYDDKMSKIWPEFAQNGKENITIDWLMSHRAGLAALDMPITIEDANDFEKMSEVIASQKPNWEPGTKSGYHAITYGWIVDQIVRRSDPKGRSVGRFFKEEVADVHGIDFHIGLPPSEEHTVSRLSMPSTLHLVREIVHDPRVLIVLAVFNLRPPNSIARKIAANPTWFKLEQDVNTFNNPTLHAMEQVAALGITKSRDLARLFSLVQQGKLFSTELLEKFRAPQVQGIDEVVMTPLPKGHGFLYERHPMGGKKWLVGHPGYGGSTVMMDLEDGITIAYVSNGLKTGMGELTRTYRHLRDSVFECLEKQKTGQSVMIEEAVQAVAA
What are the official names of this protein?
Beta-lactamase domain-containing protein 2.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RUVB_STRPQ
Sequence: MARILDNDVMGNEEFSDRTLRPQYLHEYIGQDKVKEQFAIFIEAAKRRDESLDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPAVEKAGDLVAILNELEPGDILFIDEIHRMPMSVEEVLYSAMEDFYIDIMIGAGDTSRSIHLDLPPFTLIGATTRAGMLSNPLRARFGITGHMEYYQEKDLTEIVERTATIFEIKIDHEAARKLACRSRGTPRIANRLLKRVRDYAQIIGDGIITAQITDRALTMLDVDREGLDYIDQKILRTMIEMYQGGPVGLGTLSVNIAEERNTVEEMYEPYLIQKGFLMRTRTGRVATQKAYRHLGYPYQNT
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: VAMP7_BOVIN
Sequence: MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDFERSRAFNFLNEIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIMVRNIDLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLARAMCMKNLKLTIIIIIISVVFIYIIVSPLCGGFTWPNCVKK
What is the function of this protein?
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome.  Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion.  Required for calcium regulated lysosomal exocytosis.  Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi.  Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells.  Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity).
What are the official names of this protein?
Vesicle-associated membrane protein 7, VAMP-7, Synaptobrevin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single- pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single- pass type IV membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein. Synapse, synaptosome. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).
Protein: MVP_PLRV1
Sequence: MSMVVYNNQECEEGNPFAGALTEFSQWLWSRPLGNPGAEDAEEEAIAAQEELEFPEDEAQARHSCLQRTTSWATPKEVSPSGRVYQTVRHSRMEYSRPTMSIRSQASYFSSSARPLPPPPVPSLMSWTPIAKYHPSSPTSTSSKLRRAAPKLIKRG
What is the function of this protein?
Together with movement protein P3a, facilitates long-distance movement of virions in host (PubMed:30373157).  Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding (Probable).  The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier (Probable).  Binds ssRNA (By similarity).
What are the official names of this protein?
Movement protein P17, MP, 17 kDa protein, MP17.
What is the protein family that this protein belongs to?
Belongs to the polerovirus movement protein family.
What are the subcellular locations of this protein?
Host cell junction, host plasmodesma. Host mitochondrion outer membrane. Host Golgi apparatus. Host chloroplast envelope. Note=Localizes to secondary branched plasmodesmata in source organs. Targeted to plasmodesmata in an actin- and endoplasmic reticulum-Golgi-dependent manner (By similarity). P3a directs P17 to the mitochondrial outer membrane while P17 regulates the localization of the P3a-P17 heterodimer to plastids (PubMed:30373157).
Protein: RS19_CAEEL
Sequence: MTRATSIKDVDQHEATKSIAHFLKKSGKVKVPEWSDLVKLGVNKELAPVDPDWFYTRAASLARHLYFRPAGIGAFKKVYGGNKRRGVAPNHFQTSAGNCLRKAVQQLEKIKWVEKHPDGKGRILSKQGRKDLDRIATSLRSSGQQA
What are the official names of this protein?
40S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS19 family.
Protein: NORD_BRUAB
Sequence: MLDFLELEETVGRAWHRLIGKTGSWPQYPDHAVQLVDIRQRLAICFRGFGGDIAVQIAPARARTSTHRLGLRQRMALGEEKLAQPLRDEATLMLPPEIALFPDRQLNYDLYVWLVGYMAVMPMDADALPEDALRRDLAALQIAEQTVERACRAFPGLKPRYKRLCAAILAERPKRPLHRLEQQVEARILSLLKQGADLPDDALPTIFPHRGPAGYLPALPVPLWPGLMKREEVAPRTGEDEPVRNSQSEGAETGRQIAQRERQDPRHADRSPFILNRFEKILAMAEMVSVDRPSDDSDEQNAKSADELDDLTLGERKGRPAARFRFDLDLPPEAVDRSLLTAELTYPEWDYRKGAYLPDHCAVLAAPVQEKEKPLELDAAAQSLVRRVRRQFEILRPGREVLRAQLDGTDLDLDAVVRSRCDLAAGGQGSDRVHLMSRPQANDLAVTLLVDVSLSTDAWVDNRRVLDVEKEALLVLANGIAACGDRCSILTFTSRRRSWVRVETVKDFDESFGPTVEHRIAALKPGFYTRMGAAMRHATAKLAEQPNRKKLLLLLTDGKPNDVDHYEGRFALEDSRRAAGEVRAKGVNVFAVTVDREASAYLPALFGRGGYALVANLAKLPVAMPAIYRMLAG
What is the function of this protein?
Part of the operon norEFCBQD encoding nitric oxide reductase.  Essential virulence factor, probably involved in the detoxification of nitric oxide (NO) produced in the macrophages during the innate response against infection (By similarity).
What are the official names of this protein?
Protein NorD.
Protein: PSBL_PHOTN
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DBP8_NEUCR
Sequence: MPSATAAKAKKANANANLKSKVNKAPAVTEIDEQSGHSEDESDFGSELDVEDESAASDEEDEDEDEDEHDLEEGVSDEGEGVSDEEEGVSDEDEDEENQSAGSGSDSDSDSLDSDAPRKRRRTSPTIDDIVTQLEDEEEDDTPVAPVKPVFNNVPSRIKKKQAEAPKTEKTEEATPALPVPEPASTVSVPIDANTTFDALNVRPWLVQSLANMAIKRPTGIQKGCIPEILKGRDCIGGSRTGSGKTVAFAVPILQQWAANPSAIFGVILTPTRELALQIMEQVIALSQPHVLKAVLITGGADMRKQAIDLAKRPHLVIATPGRLADHIRTSGEDTICGLRRVKFIVLDEADRLLANSGHGSMLPDVEECFSVLPPPSERQTLLFTATMTPEVKALSERPPIPGRAPVFVCEVDTQRLAIPATLRQMHLQVPVTHREHYLHMFLLTPQNVDKSVIIFCNRTSTADFLHHLLRLLDHRVTSLHSKLPQSQRIDNLGRFRASAARILVATDVAARGLDIPEVKIVINYDIPRDPDDYIHRVGRTARAGRKGDAVTFVGQRDVDLVLAIEQRVGRQMEAWTEEGVNLETRVIRDALKVVGEKKREALLEIEEQKEVGGKRKRGKEKLRAM
What is the function of this protein?
ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites.  Required for vegetative growth (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase dbp-8.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GLYA_ALKCK
Sequence: MEHLKTQDPAVFEAIRQELGRQRDKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRYYGGCEYVDIAEDVARDRAKQLFGAAYVNVQPHSGAQANMGVYFTILEHGDTVLGMNLSHGGHLTHGSPVNFSGIQYRFVEYGVREDDKRIDYEAVREAAKTHQPKLIVAGASAYPREIDFKKFREIADEVGAYLMVDMAHIAGLVAAGLHQNPVPYAHFVTTTTHKTLRGPRGGMILCNEETAEEFGKKLDKSIFPGIQGGPLMHVIAAKAVAFGEALSDEFKTYAKQIIANAKRLGEKLQAEGVDIVSGGTDNHLLLLDLRSLQLTGKVAEKALDAVGITTNKNAIPFDPEKPFVTSGIRIGTAAVTSRGFGENEMDEIGELIALTLKNIDNEEALNSVRSRVAALTKTFPMYPNL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P46_MESHJ
Sequence: MLRKKFLYSSAIYATSLASIIAFVAAGCGQTESGSTSDSKPQAETLKHKVSNDSIRIALTDPDNPRWISAQKDIISYVDETEAATSTITKNQDAQNNWLTQQANLSPAPKGFIIAPENGSGVGTAVNTIADKGIPIVAYDRLITGSDKYDWYVSFDNEKVGELQGLSLAAGLLGKEDGAFDSIDQMNEYLKSHMPQETISFYTIAGSQDDNNSQYFYNGAMKVLKELMKNSQNKIIDLSPEGENAVYVPGWNYGTAGQRIQSFLTINKDPAGGNKIKAVGSKPASIFKGFLAPNDGMAEQAITKLKLEGFDTQKIFVTGQDYNDKAKTFIKDGDQNMTIYKPDKVLGKVAVEVLRVLIAKKNKASRSEVENELKAKLPNISFKYDNQTYKVQGKNINTILVSPVIVTKANVDNPDA
What are the official names of this protein?
46 kDa surface antigen, p46.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: REX_STRPQ
Sequence: MVIDKSIPKATAKRLSLYYRIFKRFHADQVEKASSKQIADAMGIDSATVRRDFSYFGELGRRGFGYDVTKLMNFFADLLNDHSTTNVILVGCGNIGRALLHYRFHDRNKMQIAMGFDTDDNALVGTKTADNIPVHGISSVKERIANTDIETAILTVPSIHAQEVTDQLIEAGIKGILSFAPVHLQVPKGVIVQSVDLTSELQTLLYFMNQNHLD
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_DESRM
Sequence: MAIQKRVLVAMSGGVDSSVTAALLQQQGYDIVGVTMQIWDPEVTVVGDDYVGCCSLTAVDDARRVANVLGIPYYVLNFRELFTEKVIQYFVDEYFQGRTPNPCIACNRFIKFEALLQRARQMGFDYIATGHYARLGYSEEFQRYTVKKALDDKKDQSYVLYGFTQDQIAHTLMPLADYTKDQVRGIAKEMGLPTYSKPESQEICFVHDNNYRNFLDERSQGGIKPGPFKDLAGNVLGEHKGIPFYTIGQRRGLGLATGERTYVIDIDPDNNVVTVGSEEAIWGTELIASENNFILFENLTGPQELEAQVRYNSKPSPAIIEPYGEGLVKVTFKYPQRAITPGQAVVYYQGDYLVGGGTIEKTIKQKN
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECM14_COCPS
Sequence: MHILQVITGATLVSVPFVSAIPSSTSEFLPSTAEQNSAVLHSQGRSPPRLWTRLRDSIIETIWRVPSRQHNPSRIPSSLSIPRAPSSIRARYGDDVVLRFTIRSQNDVQALIEASNILFLDIWASTNEWVDIRLAKDVVSSLLGLLPSSLRTAHVPIIHDLAQAVYESYPQPVSSVPNPHHAFSPSVQQSSETQNIFFQDYQPLSVIIPWMRLLASMFSTHVRLVNLGTSYEGREIVGFRIGVRPANADLPTERRKAIVITGGSHAREWIGVSTVNYVAYSLITGYGKSRAITKLVEEFDWVLIPTMNPDGYVYTWETDRLWRKNRQENNLQFCPGVDLDRTWGYEWDGSDSRSNPCSEDFAGDGPFGGRESKVIAQWALNETNHHNVTFVGFLDLHSYSQQILYPYSYSCTNIPPTLENLEELAIGIAKAIRLTDHEHYDVSSACEGSVSSHKKRRGAALRSMQSAGGSALDWFYHDLHVRYAYQLKLRDKGGYGFLLPKKNIVPTGKEVYNAVLVFGQFLLGRGAQDIDWEGDFQFPAHSRPNVPEKEYRGPDEEYEISNQLEDDDNENDTLLGFRTQKV
What is the function of this protein?
Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.
What are the official names of this protein?
Inactive metallocarboxypeptidase ECM14.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Vacuole. Secreted.
Protein: ATPD_SHEHH
Sequence: MAEITTIARPYAKAAFEFALEQKAVESWAEMLNFAALVSENETMQPLLSGSVASGKLAELFIGVCGEQINEQAQNLLKVMAENGRLVVLPAVAQQFVELQREYAKEVEAQIVSATELTSEQLQALSVSLEKRLARKVKLNCSIDTSLIAGVIITAGDLVIDGSVRGKVSRLSDTLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PAHO_CHICK
Sequence: MPPRWASLLLLACSLLLLAVPPGTAGPSQPTYPGDDAPVEDLIRFYNDLQQYLNVVTRHRYGRRSSSRVLCEEPMGAAGC
What is the function of this protein?
Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions.
What are the official names of this protein?
Pancreatic polypeptide, APP, PPP.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: LNT_RHILO
Sequence: MERLAGRIILLWGWRRALVAFLAGALAVLGQAPYDFFAACFISFPLLVWLLDGATGEASGSLFRRLLPAFAVGWWFGFGYFLAGLWWIGSALLVEADEFAWALPFAVVGIPFALAFFYGFATLVARLLWSSDIGRIAALAFGFGLTEWLRGFLFTGFPWNAIGYAAMPVPLLMQSVSVTGMIGMNVLAVFLFSLPALLVARRHLRLGAALFVLLASAHVGFGYIRLAAPEKPAERSLDVRIVQPAVDLSEKWDASVRDRIFATLLGLSAKAPDPGHGKPQLILWPETSVPFLFTERPDALTALGDMLADGQMLIAGVVREEGGSAASTDSRYYNSVVAINDRGEITDAVDKVHLVPFGEYLPFGDLLNRFGIAQLVAGPVTFAAGNERHAISLPGGIRALPFICYEVIFPDLVAVDATSAQLIVNVTNDAWFGDTPGPYQHFRQAQIRAVENGLPLLRAANNGISAVVDPRGRIVDALAIDARGAIDVKVPISGQAVVSSAQRRINGMLIMLLFALVGALLNVRQRLRVN
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NOP12_YARLI
Sequence: MTTTKDNSGLAALFANSSGPRQKPQRAGKVDPVRDQQEDKMEVEDEEEDEEEDEEDEEEDEEDEEDEEEKEEDDDDDDDEEEIEEPVIKKSKKNKKSKEESADLEDQYMAKLAEEVAEEKPMVAETSAEEIKVDEPESDSEDEPELDVDEETKKKLEATNKELDKADYTIFVGNVSSEVITDKTVYNNFKALFAAIGTVASVRFRSISFSKLLPRKVAFISQQFHSKRDTVNAYIVFKNVKSVKGALTLNGSVFKGFHMRVDSVAHPGAQDHKRCVFVGALDFEEQEESLWEAFSSCGDVEYVRIVRDPKTNVGKGFAYVQFKDVNSVEQALLLNGKGINELSKSTTNKRKLRVSRAKSQHSQERAKQADMKNIRNAKTEGLSRDEKSHFGRAQSRLGKAGKAQLQSIVQEGLRAKKEDGKVNLARSKRRGVKPNKNRVEKPGQSRAEKRKAMFGTPTNGAPGAGGKKKRLTTRSQKFKQDGGVKKDGDAKKDGPKKERDGSKKGSKKN
What is the function of this protein?
Involved in pre-25S rRNA processing.
What are the official names of this protein?
Nucleolar protein 12.
What is the protein family that this protein belongs to?
Belongs to the RRM RBM34 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: OBG_FUSNN
Sequence: MFIDEVIITVKAGNGGDGSAAFRREKFVQFGGPDGGDGGKGGDVIFVADSNINTLIDFKFKKLFKAQNGENGQKKQMYGKKGEDLIIKVPVGTQVRDFTTGKLILDMSVNGEQRVLLKGGKGGYGNVHFKNSIRKAPKIAEKGGEGAEIKVKLELKLLADVALVGYPSVGKSSFINKVSAANSKVGSYHFTTLEPKLGVVRLEEGKSFVIADIPGLIEGAHEGVGLGDKFLKHIERCKMIYHIVDVAEIEGRDCIEDFEKINHELKKFSEKLAGKKQIVIANKMDLIWDMEKFEKFKSYLAEKGIEIYPVSVLLNEGLKEILYKTYDMLSRIEREPLEEETDITKLLKELKIEKEDFEIIRDEEDAIVVGGRIVDDVLAKYVIGMDDESLVTFLHMMRSLGMEEALQEFGVQDGDTVKIADVEFEYFE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCS4_CAMSI
Sequence: MEVKEALFMNRGEGESSYAQNSSFTQKVASMTMPVLENAVETLFSKDFHLFQALNAADLGCATSPNTFTVISTIKRMMEKKCRELNCQTLELQVYLNDLPGNDFNTLFKGLLSKVVVGNKCEEVSCYVMGVPGSFHGRLFPRNSLHLVHSCYSAHWLSQAPKGLTSREGLPLNKGKIYISKRSPPVVREAYLSQFHDDFTMFLNARSQEVVPHGCMVLILPSRQSSDPSSMESCFTWELLAIAIAELVSQGLIDEDKLDTFNVPSYFPSLEEVKDIVERDGSFTIDHMEGFELDTLQMQENDKWIRGEKLAKAVRAFTEPIISNQFGHEIMDKLYDKFTHIVASDLEGKIPKSTSIVLVLSKIVG
What is the function of this protein?
May be involved in the biosynthesis of caffeine.
What are the official names of this protein?
Probable caffeine synthase 4.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
Protein: DNAA_SACD2
Sequence: MELPESAWEQCVSSLQSELPAQQFNTWIRPLRVQQAEASNQLHLIAPNRFVLDWVNDKFKSRIDELLSSADHHPITSVEISVAPRRSTSFETNQGVAARQKRQQEAPRQNIASSQPSNSYSRQPQQPAVEMPAESQMAQVELLPAAPPAPLNNGYNTESFAQPYNDNPMGQGKVDKVDVEGGLQHKSNLNPTFIFDNFVVGKSNQLGLAAATQVAENPGGSYNPLFIYGGVGLGKTHLMHAVGNALCVRKPGAKVVYLHSERFVADMVKALQLNAINDFKRYYRSVDALLIDDIQFFAGKERSQEEFFHTFNALLEGGQQIILTCDRYPKEINGLEERLKSRFGWGLTVAIEPPELETRVAILKRKAEQVGAPLPNDAAFFIAQRIRSNVRELEGALKRVIANAHFTGRDISVELVREALKDLLALQDRLVSIDNIQRVVAEYYKIKVSDLHSKRRSRSVARPRQVAMYLAKDLTHHSLPEIGEAFGGRDHTTVLHACRKIKEMIESDADIREDVKNLLRTLTT
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB2_WICAO
Sequence: MFKSQLRTATARSSFRSLASKLNPQRFNSSKTPLLNATRGSNRSKNSLIALAISLSAVSSSYYLYQKDKFISADVPHWKDIELTPEIVSQHNKKDDLWVVLNGQVYDLTDFLPNHPGGQKIIIRYAGKDATKIFVPIHPPDTIEKFIPPEKHLGPLVGEFEQEEEELSDEEIDRLERIERKPPLSQMINLHDFETIARQILPPPALAYYCSAADDEVTLRENHNAYHRIFFNPKILIDVKDVDISTEFFGEKTSAPFYISATALAKLGHPEGEVAIAKGAGREDVVQMISTLASCSFDEIADARIPGQQQWYQLYVNADRSITEKAVRHAEERGMKGLFITVDAPSLGRREKDMKMKFEADSDVQGDDEDIDRSQGASRALSSFIDPSLSWKDIAFIKSITKMPIVIKGVQRKEDVLLAAEHGLQGVVLSNHGGRQLDYTRAPVEVLAEVMPILKERGLDQKIDIFVDGGVRRGTDVLKALCLGAKGVGLGRPFLYAMSSYGDKGVTKAIQLLKDEIEMNMRLLGVNKIEELTPELLDTRSIHNRAVPVAKDYLYEQNYQRMSGAEFRPGIED
What is the function of this protein?
Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate with subsequent transfer of electrons to cytochrome c.  Is involved in the utilization of (S)-lactate as a sole source of carbon for growth.
What are the official names of this protein?
L-lactate dehydrogenase (cytochrome), Cytochrome b2, Flavocytochrome b2, FCB2, L-lactate ferricytochrome c oxidoreductase, L-LCR.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: RL2_BRASB
Sequence: MALKTFNPTTPGQRQLVMVDRSALYKGKPVKALTEGKLSSGGRNNTGRITVRFLGGGHKQSYRMVDFKRDKVDVPATVERLEYDPNRTAFIALVKYQDGELAYILAPQRLAVGDTIVAGNYVDVKPGNVMPLGNMPVGTIVHNIEVKIGKGGQLARSAGTYAQIVGRDQDYVIVRLNSGEQRLVHGRCRGTIGAVSNPDHMNTSIGKAGRKRWMGRRPHNRGVAMNPIDHPHGGGEGRTSGGRHPVTPWGKPTKGKKTRTNKSTDKFILLSRHKRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ACSA_BURP1
Sequence: MSAIESVLHERRQFAPPAAVEKAAAISGMAAYRALAEEAERDYEGFWARLARETLEWRKPFGKVLDETNAPFYKWFEDGELNASYNCLDRHVAAGLGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGVGRGDRVVIYIPMSVEGIVAMQACARIGATHSVVFGGFSSKSLHERIVDVGATALVTADEQMRGGKTLPLKSIADEALAMGGCDAVKTVVVYRRTGGNVDWHAGRDVWMHEMVANESDACEPEWVGAEHPLFILYTSGSTGKPKGVQHSTAGYLLWVAQTMKWTFDWKPDDVFWCTADIGWVTGHSYITYGPLAVGATQVVFEGVPTYPNAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDRVHPRSYDLSSLRIIGTVGEPINPEAWIWYHKNVGQARCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPWPAMARTIWGDPERFKKSYFPEELGGRLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAVVGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILEQLAEVR
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.