PharMolix/UniProtQA huggingface dataset:
Protein: CDC16_MOUSE
Sequence: MNLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDILDMEEPINRRLFEKYLKDDNGSRDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLDSLPLNKLCAEEQELLRFVFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFRDFEVEKQNTEEAGLAPLQNSTKAPESRPNLEETFEIEMNESDMMLETSMSDHST
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Cell division cycle protein 16 homolog, Anaphase-promoting complex subunit 6, APC6, Cyclosome subunit 6.
What is the protein family that this protein belongs to?
Belongs to the APC6/CDC16 family.
Protein: RECR_SALPB
Sequence: MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQDVCNICSNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLASEKISELILATNPTVEGEATANYIAELCAEAGVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIIF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: NUOH_MYCSK
Sequence: MIHPDPTLFGHDPWWLILAKAVGVFVFLVLTVLAAILIERKVLGRMQMRFGPNRVGPKGLLQSLADGIKLALKEGITPAGVDKPVYLLAPVISVIPAFLAFAVIPMGGEVSVFGHRTALQLTDLAVAVLYILAVTSVGVYGIVLAGWASGSTYPLLGGLRSSAQVVSYEIAMALSFATVFLYAGTMSTSGIVAAQTSTWYVFLLLPSFLVYVTSMVGETNRAPFDLPEAEGELVGGFHTEYSSLKFAMFMLAEYVNMTTVSALATTMFLGGWHAPWPISLWEGANSGWWPLLWFTAKVWVFLFVYIWLRGTLPRLRYDQFMAIGWKMLIPVSLAWIMIVATAHSLRTTGHGGWASGLLIAGTVLTFGLAVILWRTMRFRADRTVPARTAADVFPIPPIPGRAGTARTPESRETTDA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ANMK_CLOD6
Sequence: MYSVGLMSGTSLDGIDAVLAEISGNGRNTKVKQIEFITLEISKDIKDEIRKCCIEEESSVDLICSLNFKLGYLFSKAVKSVCHKANFHIANLDFIASHGQTIFHIPRSYNNFVSSTLQIGEPAVIAYETNTKVISNFRVMDIAAGGEGAPLVPYSEFLLYSDKNKNLALQNIGGIGNITIIPKSCNIDDVFAFDTGPGNMIIDGVCQRLFNRKYDKNGYFASKGKINEEMLKDLMSHKYLSQAPPKSTGREVFGQVYLDNMLNKYKHVDKYDLIATVTMFTAKAIYYNYKNFILPKVNVDTLLIGGGGAHNLTLIGYIKELLLEVEVLTQDEYGYSSDAKEALAFVILGNETLNNSFSNVISATGAKNKVILGNITPKPFGGK
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: ISPF_FRATM
Sequence: MSFRIGHGYDVHKFTSAKQNIIIGGVEIAYHLGLEAHSDGDVLIHALCDAILGALGLGDIGKHFLDTDNQFKNIDSKFFLAEIKKMLDEKQYSISNIDCTIIAQAPKMLPHIEKMRACLANILEIQISQINIKATTTERLGFIGREEGIATHVVCLLYR
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RNH3_STRP8
Sequence: MNTLVLKIDAILSKHLKKQLAPYTISSQNTYVAFAAKKNGVTVLLYKSGKLVLQGNGANALAQELNLPVAKTVFEASNNSQDIPIIGSDEVGNGSYFGGIAVVASFVDPKDHSFLKKLGVDDSKKLSDKTIQQIAPLLEKQIPHQSLLLSPKKYNELVGKSKPYNAISIKVALHNQAIFLLLQKGIQPKQIVIDAFTSQSNYEKHLKKEKNHFPNPLTFQEKAESHYLAVAVSSIIARNLFLDNLDQLGQDLGYQLPSGAGSASDKVASQLLAAYGMSSLEYSAKLHFANTHKAQALLTK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLAC1_MOUSE
Sequence: MNLRKFLGGTVLVAFMLFSYSEQNQVNVLCSTDWFMVTVHPFLLNNDVYVHFYEVHLGLGCPPNHVHPHFYQFHYRVTECGIRIKAVSPDVVIYSSEIHYASKGSSTKYVIPVSCAAPRRSPWLTKPYSAKAPSNNMGATPKNDTSYHVFTLPEPSEQPNCSCPPYVYNQKSM
What is the function of this protein?
May play a role in placental development.
What are the official names of this protein?
Placenta-specific protein 1, EPCS26.
What is the protein family that this protein belongs to?
Belongs to the PLAC1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMC_ESCF3
Sequence: MQCALYDAGRCRSCQWITQLIPEQLSAKTADLKNLLADFSVEEWCESVSGPEQGFRNKAKMVVSGSVEKPLLGMLHRDGTPEDLCDCPLYPSSFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGGMMLRFVLRSETKLAQLRKALPWLQEQLPQLKVITANIQPIHMAIMEGETEIYLTEQQALAERFNDVPLWIRPQSFFQTNPVVASQLYATARDWVRQLPVKHMWDLFCGVGGFGLHCATPDMQLTGIEIAPEAIACAKQSAAELGLTRLQFQALDSTQFATTQGEVPELVLVNPPRRGIGKPLCDYLSTMAPRFIIYSSCNAQTMTKDIRELSGYRIERVQLFDMFPHTAHYEVLTLLVKQ
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: YOBB_ECOLI
Sequence: MSFWKVAAAQYEPRKTSLTEQVAHHLEFVRAAARQQCQLLVFPSLSLLGCDYSRRALPAPPDLSLLDPLCYAATTWRMTIIAGLPVEYNDRFIRGIAVFAPWRKTPGIYHQSHGACLGRRSRTITVVDEQPQGMDMDPTCSLFTTGQCLGEPDLLASARRLQFFSHQYSIAVLMANARGNSALWDEYGRLIVRADRGSLLLVGQRSSQGWQGDIIPLR
What are the official names of this protein?
Uncharacterized protein YobB.
Protein: FADA_VIBCH
Sequence: MNTVVIVDCLRTPMGRSKGGAFRHQRAEDLSAHLMKGILARNPQVNPKEIEDIYWGCVQQTLEQGFNVARNAALLAGLPIEIGAVTVNRLCGSSMQALHDAARAIMVGDAEICLVGGVEHMGHVPMTHGVDFHPGLSKNVAKAAGMMGLTAEMLGKLHGISRQQQDEFAARSHARAHAATLEGRFKNEILPTEGHAADGTLFTLDYDEVIRPETTVAGLAELRPVFDPANGTVTAGTSSALSDGASAMLVMSEQKAKALGLTIRARIKAMAVAGCDPSIMGYGPVPATHKALQRAGLTMQDMDVVELNEAFAAQSLPCAKDLGLLEMMDDKVNLNGGAIALGHPLGCSGTRISTTLINLMEAKDAKYGLATMCIGLGQGIATIFERP
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUNT_MANSE
Sequence: ALDDVQDGTLVTIKAGNDENVMAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITISTFPSQVATYSKAIKVTVD
What is the function of this protein?
Plays a pivotal role in regulating the expression of other pair-rule genes such as eve, ftz, and h.  Plays a role in the developmental pathways of sex determination and neurogenesis (By similarity).
What are the official names of this protein?
Segmentation protein Runt.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIEAP_RAT
Sequence: MAENLKKLAQSESFLSLQDKVCFWANDYQTNSCDQNLNCCIELIEQVAKVQAQLFAILTATAQEGGHNEGVETIKSRLLPLLQTSFSSLGVGKIIQTEIRPIQDFQLRSKNRQSSLDQEQQQSDGDSFIESQPTQVQDDLTESGKNLEGTKNGSAISLLAAEEEINQLKKQLKSLQAQEDARHKTSENRRAEISRTDRRPSGKRNSERPQDVVSNYEKHLKNLKDEIAVLSAEKSGLQASHRQTRSRSPSPGPRGPRGPRGRRRSRSHSRSHSRSHSRSHSHSNSHSNSRSNSPCTTVAKIRSPSPNRSKMSSVARKAALLSRFSDAYSQARLDAQCLLRRCIDRAETVQRIIYIATVEAFHIAKMAFRHFKIRVRKMLTPSHVGSNDFETAVSDYIVCHLDLYDSQSSVNDVIRAMNVNPKISFPPEVDFCLLTDFIQEICCIAFAMQSLEPPLDIAFGADGEVFNEAKYRRSYDSDFTAPLVFYHVWPALMENDCVIMKGEAVTKRGAFWTTVRPVMRCRSRSLSPICPRSRFGISTVHSCVTIPADDLVSRSRSPSPIRCTFARY
What is the function of this protein?
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage.  Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen.  Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity).  The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).  May have a role in spermatogenesis, especially in cell differentiation from late elongate spermatids to mature spermatozoa.
What are the official names of this protein?
Mitochondria-eating protein, Spermatid-expressing gene 1 protein, Spetex-1, Spermatogenesis-associated protein 18.
What is the protein family that this protein belongs to?
Belongs to the MIEAP family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress.
Protein: PANB_PSEPW
Sequence: MPEVTLTTLHGLKAKGEKITMLTCYDATFAKAASQAGVEVLLVGDSLGMVLQGHDSTLPVTTAEMAYHTACVKRGNEGALILADLPFMAHATPEQAFANCAMLMQAGAHMIKLEGAAWLAETIRLLAERGVPVCAHMGLTPQTVNVLGGYKVQGRQEAQARQMRADAIALEQAGAAMLLLECVPSELAAEITQAVSIPVIGIGAGNATDGQVLVLHDMLGLSLSGRVPKFVKNFMVGQPDIGSALAAYVKAVKDVSFPASEHGFSA
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CATM_ACIAD
Sequence: MELRHLRYFVTVVEEQSISKAAEKLCIAQPPLSRQIQKLEEELGIQLFERGFRPAKVTEAGMFFYQHAVQILTHTAQASSMAKRIATVSQTLRIGYVSSLLYGLLPEIIYLFRQQNPEIHIELIECGTKDQINALKQGKIDLGFGRLKITDPAIRRIVLHKEQLKLAIHKHHHLNQFAATGVHLSQIIDEPMLLYPVSQKPNFATFIQSLFTELGLVPSKLTEIREIQLALGLVAAGEGVCIVPASAMDIGVKNLLYIPILDDDAYSPISLAVRNMDHSNYIPKILACVQEVFATHHIRPLIE
What is the function of this protein?
Positively regulates the expression of catA, catBCIJFD and benPK in response to cis,cis-muconate.  It binds to the catB-catM intercistronic region, to a specific sequence upstream of catA and to the benPK promoter region.  Can also repress pca genes.
What are the official names of this protein?
HTH-type transcriptional regulator CatM, Cat operon transcriptional regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: YT31_CAEEL
Sequence: MMSGVPPLKPSRSFLPQDSGPMLHRSPSGAKRKIRQKREEASRPSPFLSPSSSSSQTSISPTPTETSSNYRSLVDSGDYQSILPDFDPSFVPVPTPRLSVPFSASMSTLELSSSTLSSPVTAPAPPPPPTSKPTVEVHPMPTDERSPSMASSLNGSIDIDIYKPKPPVPIKPKGLRIDHLNR
What are the official names of this protein?
Uncharacterized protein B0353.1.
Protein: APOC1_CYNBR
Sequence: MRLILSLPVLAVVLAMVLEGPAPAQAAPDMSSTLESIPGKLKEFGSTVKEKFRTAIDQIQKSDFPEKTRNWFSDVFQKVKEKFETTFS
What is the function of this protein?
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor.  Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL.  Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP).  Binds free fatty acids and reduces their intracellular esterification.  Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
What are the official names of this protein?
Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CXL13_MOUSE
Sequence: MRLSTATLLLLLASCLSPGHGILEAHYTNLKCRCSGVISTVVGLNIIDRIQVTPPGNGCPKTEVVIWTKMKKVICVNPRAKWLQRLLRHVQSKSLSSTPQAPVSKRRAA
What is the function of this protein?
Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes.  Binds to BLR1/CXCR5.  May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.
What are the official names of this protein?
C-X-C motif chemokine 13, B lymphocyte chemoattractant, CXC chemokine BLC, Small-inducible cytokine B13.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYP61_ARATH
Sequence: MSSAQDPFYIVKEEIQDSIDKLQSTFHKWERISPDMGDQAHVAKELVATCGSIEWQVDELEKAITVAAKDPSWYGIDEAELEKRRRWTSNARTQVRNVKSGVLAGKVSSGAGHASEVRRELMRMPNSGEASRYDQYGGRDDDGFVQSESDRQMLLIKQQDEELDELSKSVQRIGGVGLTIHDELVAQERIIDELDTEMDSTKNRLEFVQKKVGMVMKKAGAKGQMMMICFLLVLFIILFVLVFLT
What is the function of this protein?
Vesicle trafficking protein that functions in the secretory pathway; the fusion of phospholipid vesicles containing SYP61 and VTI12 is triggered by YKT61 and YKT62 (PubMed:15919093, PubMed:21826108).  Together with VTI12, required for membrane fusion (PubMed:15919093).  Involved in osmotic stress tolerance and in abscisic acid (ABA) regulation of stomatal responses (PubMed:12468724).  Plays a role in the exocytic trafficking of cellulose synthases (CESAs) and the transport of cell wall components to the plasma membrane (PubMed:21826108, PubMed:25535279).  Together with SYP121, regulates the post-Golgi trafficking of the aquaporin PIP2-7 to the plasma membrane, thus modulating cell membrane water permeability (PubMed:25082856).
What are the official names of this protein?
Syntaxin-61, AtSYP61, Osmotic stress-sensitive mutant 1, Protein SYNTAXIN OF PLANTS 61.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Prevacuolar compartment membrane; Single-pass type IV membrane protein. Note=And along the cell wall inner surface (PubMed:23832588). Intracellular trafficking is modulated by TNO1 (PubMed:21521696).
Protein: RL25_LEPBL
Sequence: MSQSTIHKIAVKKRTETGKNENNRLRSSGMIPVNIIGAGVATSGAVNEKELAKMVHSGIRQSTLIELDVEGQGQQKVFVKEIQRFPEIDRIRHVDFYKVVPGQKIVTKIGIETTGVAKGSKTGGQFEHIIHEIRVKTIPEDLLENLTIDVTDLDVGDSIKISQLKVPASWEILINGDPIVTSVNKTKALLAAERAEAKGAVPDDAKAKKGKK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: RS7_TREPA
Sequence: MGRKRRVSRRVPPPDARYNSVVLAKFICRMMLAGKKATAVGIMYDCLERIQQRTGEEPLPVFTKALENVKPAVEVKSRRVGGSTYQVPMEIRETRREALGMRWIIGAARRRSGRGMSERLAAEILDAYHSTGTAFKRKEDTHRMAEANKAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: PMTA_ARATH
Sequence: MKLSDVGLDVVKTPRLVKLIAFAFLSISTIFLFNHFSDSFSYPSLPFPISSSSNVTEAIQTNITSVAAVAPSPPPRPRLKISPPPLPPTVVRTGIINENGAMSDSFEIGGFDPDSIDELKSATGNSSVEEKESPEVGFQIEKLKLCDKTKIDYIPCLDNEEEIKRLNNTDRGENYERHCPKQSLDCLIPPPDGYKKPIQWPQSRDKIWFNNVPHTRLVEDKGGQNWIRREKDKFVFPGGGTQFIHGADQYLDQISQMIPDITFGSRTRVALDIGCGVASFGAFLMQRNTTTLSVAPKDVHENQIQFALERGVPAMVAVFATRRLLYPSQSFEMIHCSRCRINWTRDDGILLLEVNRMLRAGGYFVWAAQPVYKHEDNLQEQWKEMLDLTNRICWELIKKEGYIAVWRKPLNNSCYVSREAGTKPPLCRPDDDPDDVWYVDMKPCITRLPDNGYGANVSTWPARLHDPPERLQSIQMDAYISRKEIMKAESRFWLEVVESYVRVFRWKEFKLRNVLDMRAGFGGFAAALNDLGLDCWVMNIVPVSGFNTLPVIYDRGLQGAMHDWCEPFDTYPRTYDLIHAAFLFSVEKKRCNITNIMLEMDRMLRPGGHVYIRDSLSLMDQLQQVAKAIGWTAGVHDTGEGPHASVRILICDKRI
What are the official names of this protein?
Probable methyltransferase PMT10.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: FOLD2_ROSDO
Sequence: MAATIIDGKAFAAKVRAQVAEHVTRIKQDHGITPGLAVVLVGEDPASQVYVRSKGKQTVEAGMNSYEHKLDADTSEADLLAVVDKLNKDPNVHGILVQLPLPKHLDEDLIINSIDPAKDVDGFHISNVGLLGTGQKSMVPCTPLGCLMMLREHHGSLSGMNAVVIGRSNIVGKPMAQLLLNDSCTVTIAHSRTKDLPDVVRGADIVVAAVGRPEMVPGDWIKPGATVIDVGINRIDAPEKGEGKTRLVGDCHYDSCAETAGAITPVPGGVGPMTIACLLANTVTSCCRANGLEEPTGLTA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 2.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: VTC3_YEAST
Sequence: MLFGIKLANDVYPPWKDSYIDYERLKKLLKESVIHDGRSSVDSWSERNESDFVEALDKELEKVYTFQISKYNAVLRKLDDLEENTKSAEKIQKINSEQFKNTLEECLDEAQRLDNFDRLNFTGFIKIVKKHDKLHPNYPSVKSLLQVRLKELPFNNSEEYSPLLYRISYLYEFLRSNYDHPNTVSKSLASTSKLSHFSNLEDASFKSYKFWVHDDNIMEVKARILRHLPALVYASVPNENDDFVDNLESDVRVQPEARLNIGSKSNSLSSDGNSNQDVEIGKSKSVIFPQSYDPTITTLYFDNDFFDLYNNRLLKISGAPTLRLRWIGKLLDKPDIFLEKRTFTENTETGNSSFEEIRLQMKAKFINNFIFKNDPSYKNYLINQLRERGTQKEELEKLSRDFDNIQNFIVEEKLQPVLRATYNRTAFQIPGDQSIRVTIDSNIMYIREDSLDKNRPIRNPENWHRDDIDSNIPNPLRFLRAGEYSKFPYSVMEIKVINQDNSQMPNYEWIKDLTNSHLVNEVPKFSLYLQGVASLFGEDDKYVNILPFWLPDLETDIRKNPQEAYEEEKKTLQKQKSIHDKLDNMRRLSKISVPDGKTTERQGQKDQNTRHVIADLEDHESSDEEGTALPKKSAVKKGKKFKTNAAFLKILAGKNISENGNDPYSDDTDSASSFQLPPGVKKPVHLLKNAGPVKVEAKVWLANERTFNRWLSVTTLLSVLTFSIYNSVQKAEFPQLADLLAYVYFFLTLFCGVWAYRTYLKRLTLIKGRSGKHLDAPVGPILVAVVLIVTLVVNFSVAFKEAARRERGLVNVSSQPSLPRTLKPIQDFIFNLVGE
What is the function of this protein?
Accessory subunit of the vacuolar transporter chaperone (VTC) complex.  The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP.  VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046).  The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:25315834, PubMed:19390046).  PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834).  The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419).  Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419).  Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules.  Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106).
What are the official names of this protein?
Vacuolar transporter chaperone 3 complex subunit 3, Phosphate metabolism protein 2, SPX-dependent polyphosphate polymerase VTC subunit 3, Vacuolar membrane polyphosphate polymerase accessory subunit 3, PolyP polymerase.
What is the protein family that this protein belongs to?
Belongs to the VTC2/3 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: CAPP_STRS2
Sequence: MAIQKLENYNNKEAIREEVTILTSILEEVAAQMMPAETFAKIVELSQLSRQDDYQALIAIISQLNNDELAVISRYFAVLPLLINISEDVDLAYEINHQNNIDQDYLGKISTTIDMVSKQENAAEILEKLNVVPVLTAHPTQVQRQSMLDLTKHIHELLRRYRDVKLGLLNKNKWEDELRCYIEIIMQTDMIREKKLKVTNEITNVMEYYNSSFIKAVTKLQREYKRLAAEKGIVLNNPRPITMGMWIGGDRDGNPFVTAETLKLSALTQCEVIMNYYDEQLYKLYRNFSLSTSIVNVSTAVKMLADLSEDSSVYRENEPYRRAFHYIQMKLANTRDYLVHNKPSDVRYSNVAEFKADLLAIKQSLVENKSMALLKGDFTELLEAVEAFGFYLASIDMRQDSSIHEASVAELLASARIVEDYSSLSEEAKCHVLLKQLETDPRILSATHMPKSEQLEKELAIFAAARELKDKLGEEIIKQHIISHSESVSDLLELAVLLKEVGLVDVDKARVQIVPLFETIEDLDNAPDTMRQYLQLDLAKRWIAGNKYYQEIMLGYSDSNKDGGYLSSGWTLYKAQNELTQIGQDYGVNITFFHGRGGTVGRGGGPSYDAITSQPFGSIKDRLRLTEQGEVIGNKYGNKDAAYYNLEMLVSATLDRMVTQMITDPNEIDGYRETMDEIVSDSYRIYRDLVFNNPHFYDYFFAASPIREVSSLNIGSRPAARKTITEIGGLRAIPWVFSWSQNRVMLPGWYGVGSSFKRFIDKHPDNLSKLQKMYESWPFFRSLLSNVDMVLSKSNMNIAFEYAKMCESEEVRNIFHVILDEWQLTKEIILSIEQNDELLAELPFLKASLDYRMPYFNVLNYIQIELIHRLRRGELSKEQENLIHITINGVATGLRNSG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: ASSY_LIMRJ
Sequence: MSKEKIVLAYSGGLDTSVAIAWLKNKGYDVIACCIDVGEGKDLEAIKEKGLQVGAWKSVVIDAKRDFAEQFVLPALQAHAMYEQKYPLVSALSRPLIVQKLVAVANQYGATAIAHGCTGKGNDQVRFEAGIHALAPEMKIEDPIRDWHWSREEEIQYAKDNGIPVPITKASPYSIDENLWGRANECGILEDPWAAAPADAYDRTVSIEEAPDTPTTIEITFNEGVPTAIDGEEMPLDQLIMKLDKLAGSHGIGRIDHVENRLVGIKSREIYECPAATVLLAAHKDLEDLTQEREVAHFKPLIEQKMSGIIYNGLWYSPLMKSLVAFIDESQAVVNGVVRVKLFKGNVICEGRKSPNSLYDKNLATYTSADEFDQEAATGFIKLWELPDKVYAQVQNKNKKKVKENTSDAY
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.