PharMolix/UniProtQA huggingface dataset:
Protein: CID2B_SALSA
Sequence: MVLETISKIIKTQLPAYLKKFPLPETIGGFARLTVLDWLRLLPLLGILALLGYLTIRPFLPKKKKQKDSLINLKIQKENPKVVNEIDIEDLKSTNVCYCRCWRSKTFPVCDKSHIKHNELTGDNVGPLILKKKIL
What is the function of this protein?
Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum.  Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity).
What are the official names of this protein?
CDGSH iron-sulfur domain-containing protein 2B.
What is the protein family that this protein belongs to?
Belongs to the CISD protein family. CISD2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein.
Protein: RNH_DICNV
Sequence: MPAPILDIFVDGACKGNPGIGGWGVLMRYGQHEKVLMGAQWHTTNNRMELTAAIEALKAIKRPCPILISTDSVYVKNGITHWLPVWKKNNWRNASKKPIKNIELWQALDQLNQRYEIEWRWVKGHAGNPGNEIADELANRAIESLRQKTS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DISA_BACAC
Sequence: MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: RS16_CAMJE
Sequence: MTVIRLTRMGRTKRPFYRIVVTDSRKRRDGGWIESIGYYNPMVEPEVIKVDAERLAYWKSVGAKLSDKVASITSK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: HSF4_MOUSE
Sequence: MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKVPALRGDDSRWRPEDLSRLLGEVQALRGVQESTEARLQELRQQNEILWREVVTLRQSHSQQHRVIGKLIQCLFGPLQTGPSSTGAKRKLSLMLDEGSACSASAKFNACPVSGALLQDPYFIQSPLPETTLGLSPHRARGPIISDIPEDSPSPEGHRLSPSGGCRRVKGLALLKEEPASPGGDGEAGLALAPNECDFCVTAPPPLPVAVVQAILEGKGSYSPEGPRSVQQPEPRGPREVPDRGTLGLDRGNRSPESLLPPMLLRPAPETLEPVAPVDVLGPSLHGREWTLMDLDMELSLMQPLAPETDEAELTVKELNSSGVGKDHTLGTPLMLDVQADLEGAALSVPGALTLYNVTESNASYLDPGASPSSP
What is the function of this protein?
Transcriptional activator.
What are the official names of this protein?
Heat shock factor protein 4, HSF 4, mHSF4, Heat shock transcription factor 4, HSTF 4.
What is the protein family that this protein belongs to?
Belongs to the HSF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CHEB_DESHY
Sequence: MNQPKSPITVLIVDDSPFMRLTLQKILSQDPEIKVLDTARDGKEGIEKLQALRPQVVTMDIEMPQIDGLQALGEIMRWQPTPIIILSALTTEGAQASVKALEAGAFDVVAKPSGGPGADIQALARDLIDKVKAAAQVNLGRLGKKGAVSRISSASGSRPPWTAGAASENTNRLSSPGSTSSTLGSAKGRSLDSGEALPKYPVEIVAIGTSTGGPSALQAVLTQLPGNLPVPVLVAQHMPPGFTAPLAQRLNGMSPLTIREGVHGEALKAGTIYFAPAGKQMQVQSRGSQLILHIGDESPITTLYHPSVDVMFMSLAKEVGKGTLGVVMTGMGNDGLRGMREIKERGGYAIAEAEETCVVYGMPRAIVDAGLANRVAPLGEIARHIVECVQRR
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDEP_SHIFL
Sequence: MKKKIESYQGAAGGWGAVKSVANAVRKQMDIRHDVIAMFDMNKPEGFDCPGCAWPDPKNSASFDICENGAKAIAWEVTDKQVNASFFAENTVQSLLTWGDHELEAAGRLTQPLKYDAVSDCYKPLSWQQAFDEIGARLQSYSDPNQVEFYTSGRTSNEAAFLYQLFAREYGSNNFPDCSNMCHEPTSVGLAASIGVGKGTVLLEDFEKCDLVICIGHNPGTNHPRMLTSLRALVKRGAKMIAINPLQERGLERFTAPQNPFEMLTNSETQLASAYYNVRIGGDMALLKGMMRLLIERDDAASAAGRPSLLDDEFIQTHTVGFDELRRDVLNSEWKDIERISGLSQTQIAELADAYAAAERTIICYGMGITQHEHGTQNVQQLVNLLLMKGNIGKPGAGICPLRGHSNVQGDRTVGITEKPSAEFLARLGERYGFPPPHAPGHAAIASMQAICTGQARALICMGGNFALAMPDREASAVPLTQLDLAVHVATKLNRSHLLTARHSYILPVLGRSEIDMQKSGAQAVTVEDSMSMIHASRGVLKPAGVMLKSECAVVAGIAQAALPQSVVAWEYLVEDYDRIRNDIEAVLPEFADYNQRIRHPGGFHLINAAAERRWMTPSGKANFITSKGLLEDPSSAFNSKLVMATVRSHDQYNTTIYGMDDRYRGVFGQRDVVFMSAKQAKICRVKNGERVNLIALTPDGKRSSRRMDRLKVVIYPMADRSLVTYFPESNHMLTLDNHDPLSGIPGYKSIPVELEPSN
What is the function of this protein?
Probably involved in acid resistance.
What are the official names of this protein?
Protein YdeP.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
Protein: RL30_CANGA
Sequence: MAPIKTQESINQKLALVVKSGKFTLGYKSTIKSLRQGKSKLIIIAANTPVLRKSELEYYAMLSKTKVYYFQGGNNELGTAVGKLFRVGVVSVLDAGDSDILTALA
What are the official names of this protein?
60S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
Protein: KAD2_DROWI
Sequence: MAPTAAVPVERYESENIGINAILLGPPGSGKGTQAPLLKEKFCVCHLSTGDMLRAEISSGSKLGAELKKVMDEGKLVSDELVVNMIDSNLDKPECKNGFLLDGFPRTVVQAQKLDTLLDKRKTNLDAVVEFSIDDNLLVRRITGRLIHQASGRSYHEEFAPPKQPMKDDITGEPLIRRSDDNAEALKKRLESYHKQTKPLVDYYGFRGLHFKVDAARKSSDVFSKIDSIFQRQRSSKVQL
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: REV_VILVK
Sequence: MASKESKPSRTTRRGMEPPLRETWNQVLQELVKRQQQEEEEQQGLVSGLQASKADQIYTGNSGDRSTGGIGGKTKKKRGWYKWLRKLRAREKNIPSQFYPDMESNMVGMENLTLETQLEDNALYNPATYIGDMAMDGREWMEWRESAQKEKRKGGLSGQRTNAYPGK
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
What are the official names of this protein?
Protein Rev.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: PYRF_HAHCH
Sequence: MVGGPRVVVALDFSDRKQLDEFVAKLDPGLCRLKVGKELFTTFGPAIVEQLQARGFEVFLDLKFHDIPNTTAQAVKAAAGLGVWMVNVHASGGRRMMEACREVLEQESHAPLLIAVTMLTSLSDEEIVEIGFPCSAQEMVGRLAVLAQSSGMDGVVCSAQEAPLLRRAHGEEFCLVTPGIRPAAAAADDQTRIVTPAQAITDGSSYLVVGRPITRALNPLDALQQIVKEVESV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: GSA_ACIAD
Sequence: MSLSPKQVQLFEQASKHIPGGVNSPVRAFNGVGGTPVFIKKAQGAYLWDEDDKRYVDYVGSWGPMILGHAHPDIIQAVQTAAVDGLSFGAPTVHETTLADIICDIMPSIEMVRMTNSGTEATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGLLTLGEGEPTSKGVPVDFAKHTLTLPYNNIEALKECFAKFGHEIAGVIVEPVAGNMNLVTPIDGFLQAIRDVCDEYGSVFIIDEVMTGFRVALGGAQSVYQVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQAGTLSGNPLAMRAGITMFKHLREPDFYSKLEAKLQKLLTGLQAAANEAGIAFKTQQVGGMFGLYFTDQEDITSFDSMLACDTDAFKKFFHGMLERGVNLAPSAFEAGFISSAHSDEDIELTIQAAKETFAEMK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_SACD2
Sequence: MKKVDRWLLPDGIEEVLPEEASRVEGLRRRLVDLFQSWGYDYVIPPMVEFIDSLLTGSGEDAYLDTFKITDQLSGKTMGIRADITPQAARMDAHSLQREGLNRLCYAGHVMYTKPKGPLASRTPIQVGVELFGESGLDADIEVISLLLETLEAAGLPDLYIDIGHVGVYRALIEEAGISKEQEEVYFELLQAKSINSIESWVANNITDAKMAEWLLALPRLAGGNHILAEAKALFEDAPAEVSAAIDELEMIDSVLTERYPHSKRYFDLSELRGYHYYTGVIFGAFAPGLGNAIANGGRYDHVGEAFGRARAATGFAADLMSISRVTGRCELAPSGIYVEDSDADGIWAKIKQLRASGERVVCALAGQTAPYKHQHCNRKLIKQGEEFVVAPIK
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_STRA5
Sequence: MSNYAIILAAGKGTRMKSDLPKVMHKVSGITMLEHVFRSVQAIEPSKIVTVIGHKAELVRDVLGDKSEFVMQTEQLGTGHAVMMAEEELATSKGHTLVIAGDTPLITGESLKNLIDFHVNHKNVATILTADAANPFGYGRIIRNSDDEVTKIVEQKDANDFEQQVKEINTGTYVFDNQSLFEALKDINTNNAQGEYYLTDVIGIFKEAGKKVGAYKLRDFDESLGVNDRVALATAEKVMRHRIARQHMVNGVTVVNPDSAYIDIDVEIGEESVIEPNVTLKGQTKIGKGTLLTNGSYLVDAQVGNDVTITNSMVEESIISDGVTVGPYAHIRPGTSLAKGVHIGNFVEVKGSQIGENTKAGHLTYIGNAEVGCDVNFGAGTITVNYDGQNKFKTEIGSNVFIGSNSTLIAPLEIGDNALTAAGSTITDNVPIDSIAIGRGRQVNKEGYANKKPHHPSQK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIT1_AEDAE
Sequence: MATDGITSRFGFNERRRTHNRNSCRILEDKMLAKLLLLALAGLTAAYQYENSFKGYNPGYKGYDAGYKGYGYDAGYKYNNQGYSYKNGFEYGYQNAYQAAFYKHRPNVTEFEFSSWMPNYEYVYNVTSKTMTALAELDDQWTGVFTRAYLVIRPKSRDYVVAYVKQPEYAVFNERLPYGYATKFYHDMFKFQPMPMSSKPFGIRYHKGAIKGLYVEKTIPNNEVNILKAWISQLQVDTRGANLMHSSKPIHPSKNEWNGHYKVMEPLVTGECETHYDVNLIPAYMIQAHKQWVPQGQLRGEDGQFIQVTKTQNFDRCDQRMGYHFGFTGYSDFRPNTNQMGNVASKSLVSYMYLTGNWYNFTIQSSSMINKVAIAPSLVNKEPALVYAQVNMTLNDVHPYDKVPMGPAEDLKVFVDLVYSYNMPSDKKNYVRPGNETSSSSSSSSSSSSSSSESSSSSSESVENPKISPVEQYKPLLDKVEKRGNRYRRDLNAIKEKKYYEAYKMDQYRLHRLNDTSSDSSSSDSSSSSSSESKEHRNGTSSYSSSSSSSSSSSSSESSSYSSSSSSSSESYSISSEEYYYQPTPANFSYAPEAPFLPFFTGYKGYNIFYARNVDAIRSVGKLVEEIASDLENPSDLPKSNTMSKFNILTRAIRAMGYEDIYELAQKYFVSQKERQVAQFSDKKFSKRVDAWVTLRDAVAEAGTPSAFKLIFDFIKEKKLRGYEAATVIASLAQSIRYPTEHLLHEFFLLVTSDVVLHQEYLNATALFAYSNFVNQAHVSNRSAYNYYPVFSFGRLADADYKIIEHKIVPWFAHQLREAVNEGDSVKIQVYIRSLGNLGHPQILSVFEPYLEGTIQITDFQRLAIMVALDNLVIYYPSLARSVLYRAYQNTADVHEVRCAAVHLLMRTDPPADMLQRMAEFTHHDPSLYVRAAVKSAIETAALADDYDEDSKLAINAKAAINFLNPEDVSIQYSFNHIRDYALENLELSYRLHYGEIASNDHRYPSGLFYHLRQNFGGFKKYTSFYYLVSSMEAFFDIFKKQYNTKYFADYYKSADYSTNYYNFDKYSKYYKQYYYSKDSEYYQKFYGQKKDYYNDKEPFKFTAPRIAKLLNIDAEEAEQLEGQLLFKLFNGYFFTAFDNQTIENLPHKMRHLFENLEDGYAFDVTKFYQQQDVVLAWPLATGFPFIYTLKAPTVFKFEVDASAKTHPQVYKMPAGHPETENDDFFYMPQSINGSVDVNLLYHRMVDAKVGFVTPFDHQRYIAGYQKKLHGYLPFNVELGLDFVKDEYEFEFKFLEPKDDHLLFHMSSWPYTGYKDITDMRPIAENPNAKIVHDDNQSTKTMEHTFGQDMTGVALRFHAKYDFDLINFQQFWSLVQKNDFVSAVNYPFAYQPYEYHQFNLFYDSQRTHAKSFKFYAYQKFGAPSFEETGPKHPANRHSYSGNYYESNYAQPFVYSPGSQRRYEQFFRNAASGIRNSFVRYYDFGFEFYAPQYKSEFTFTTAFADSPVDKTSRQLYYFYASPMFPSQSYFKDIPFSGKQFQFCATATSEFPRVPYLKFSDFDKYYGDASQYFDFLYGESCQGGAHIAVKGKQKQTGKYREYLRFSDVAKACKEQMANGYYQFEECQQAIDQAYYYDFYDYAIEYKDVGSVAKNLTNKFYNYFQYAFYPYFESNFFYHGKSNYIKAEFEFAPYGDYYNASFFGPSYAFQVQNYPVFNDYSTYFPYFFKYTFFPRYQPYYMHRLPAHKPRNRPYYELSNYEQFAVFDRKPQYPSCSFSNDYFYTFDNKKYFYDMGECWHAVMYTVKPDYDFYAQQSHFYNSDFEYKYKNGFEEYEQFAALARRGSDNQLYFKFLFGDNYIEVFPNNGGIPFVKYNGRPYDISKSNIAHFEYKEGYPSFPFFYAFAYPNKDLEVSFFGGKLKFATDGYRARFFSDYSFYNNFVGLCGTNNGEYFDEFVTPDQCYMRKPEFFAASYAITGQNCTGPAKAFNYAYQQKAKQECVKREVYYGDIIYNQEYYHPRYRYYNHNVEESSSSSSSSSSDSSSSSSSSESSSRSRSGSSSSSSSSEEQKEFHPHKQEHSMKECPVQHQHQFFEQGDRTCFSLRPLPVCHSKCVATEKISKYFDVHCFEKDSTQAKKYKSDIGRGYTPDFKSFAPHKTYKFNYPKSCVYKAY
What is the function of this protein?
Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.  May supply aromatic amino acids to the cuticle of rapidly developing embryos.
What are the official names of this protein?
Vitellogenin-A1, VG, PVG1.
Protein: YAAI_SALPB
Sequence: MRSVLTISASLLFGLALSSVAHANDHKILGVIAMPRNETNDLTLKTPVCRIVKRIQLTADHGDIELSGASVYFKTARSASQSLNVPSSIKEGQTTGWININSDNDNKRCVSKITFSGHTVNSSDMARLKVIGDD
What are the official names of this protein?
UPF0412 protein YaaI.
What is the protein family that this protein belongs to?
Belongs to the UPF0412 family.
Protein: Y777_CROS8
Sequence: MEWLGKYWWVLVLVFLLGVLLNVIKDLKRVDHKKFMDNRPELPPHRDFNDKWDDEDDWPKKK
What are the official names of this protein?
UPF0370 protein ESA_00777.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RB11B_RAT
Sequence: MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQKPNKLQCCQNL
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel.  May also regulate constitutive and regulated secretion, like insulin granule exocytosis.  Required for melanosome transport and release from melanocytes.  Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
What are the official names of this protein?
Ras-related protein Rab-11B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
Protein: CAS6_MYCTO
Sequence: MAARRGGIRRTDLLRRSGQPRGRHRASAAESGLTWISPTLILVGFSHRGDRRMTEHLSRLTLTLEVDAPLERARVATLGPHLHGVLMESIPADYVQTLHTVPVNPYSQYALARSTTSLEWKISTLTNEARQQIVGPINDAAFAGFRLRASGIATQVTSRSLEQNPLSQFARIFYARPETRKFRVEFLTPTAFKQSGEYVFWPDPRLVFQSLAQKYGAIVDGEEPDPGLIAEFGQSVRLSAFRVASAPFAVGAARVPGFTGSATFTVRGVDTFASYIAALLWFGEFSGCGIKASMGMGAIRVQPLAPREKCVPKP
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Processes pre-crRNA into individual crRNA units.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas6.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
Protein: FUMOC_CORFA
Sequence: MRMPTNLQHPNMTAIASLPRSQNALKIVSPNTFHVDANAPLPTLVDHDSVLIRVVCVAINPVDGKSADLSATAGATSGTDFAGIVVALPPDTNSEPDDDALKIGDRVMGFVFGNNPQGRDNGAFAEYVTVPRRLLWRLPAHMSLETAASLPASLASVGMAMHYLQIPLSSLQSAISKSIASSSAAAAADDEGPFVLVYGGGTSTGCMAIQILRLAGFVPVTCCSSSSAARALSLGAAATFDYASATCGRDVREHTHDSLALAIDCISDSASMSICYEAIGGGGGRYVALDPFPVRGCVRRSVVPDWICTLTQFGRPVAWAPPYNIDERPGDRRFAEEWYRLAQRMLDAHVIRAPTLETRTGGLASVPEGISEVRMGEVKRKKLVYNIVEQKAAA
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of fumosorinone, a 2-pyridone alkaloid that acts as an inhibitor of protein tyrosine phosphatase 1B which is implicated asa negative regulator of insulin receptor signaling and a potential drug target for the treatment of type II diabetes and other associated metabolic syndromes (PubMed:25857260).  The polyketide-amino acid backbone of fumosorinone is first assembled by the PKS-NRPS hybrid fumoS (PubMed:25857260).  The PKS modules condense one acetyl-CoA starter unit with 7 malonyl-CoA units, programmed C-methylations occurring after the first 3 and the sixth extensions, and cycles of full reduction occurring after the first 2 extensions (Probable).  Because fumoS lacks a designated enoyl reductase (ER) domain, the required activity is provided the enoyl reductase fumoC (Probable).  Upon formation of the polyketide backbone on the thiotemplate, the polyketide is transferred to the NRPS module and linked to tyrosine to produce the acyltetramic acid intermediate called prefumosorinone A (Probable).  The cytochrome P450 monooxygenase fumoA then probably catalyzes an unprecedented oxidative ring expansion of prefumosorinone A to form prefumosorinone B which contains the 2-pyridone core of fumosorinone (Probable).  The cytochrome P450 monooxygenase fumoB might hydroxylate the nitrogen of prefumosorinone B, but not the acyltetramic acid prefumosorinone A, to form fumosorinone (Probable).
What are the official names of this protein?
Trans-enoyl reductase fumoC, Fumosorinone biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: PGK_BORPE
Sequence: MSNVNTLSALAKSGALSGKRVFIRADLNVPFDDAGRISEDTRIRASVPGIRLALDAGAAVMVTSHLGRPKEGALTEADSLAPVAQRLSELLGMQVRLVPDWVDGVSVEPGEVVLLENCRGNVGEKKDDEGLSRKMAALCDVYVNDAFGTAHRAEATTHGIARFAPVACAGPLLEAELDALGRALHDPKRPLVAIVGGSKVSTKLSILQSLADKVDQLVVGGGIANTFMLAAGLPIGKSLAEPEQVEQARAVIEIMKRRGAEVPIPTDVVCAKSFGADAAATVKAAADVAEDDMILDIGPQTAQRLADILKTAGTIVWNGPVGVFEFDQFAHGTEVVARAIADSAGFSIAGGGDTLAAIAKYGIADQTGYISTGGGAFLEFLEGKALPAVAVLQARAA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFLD_PHOPR
Sequence: MAHTLYDRTIAFASICQAVKLVQLVAQNGNCDREILEACLNSITVTNPSNTIEIYGNESNLRLGLETLSQEIDSSPTGSEITRYLVSVMALERKLSGRRDSMGQLGDRIDVIIRQKDHFDLLDDQMVSNLASIYLDIISPLGPRIQVTGAPAHLQQQQVQHKVRALLLAAVRGAVLWRQVGGKRRHLIFGRKQMVEQAKILLARC
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ALDO4_ARATH
Sequence: MAGDDLVFAVNGEKFEVLSVNPSTTLLEFLRSNTCFKSVKLSCGEGGCGACIVILSKYDPVLDQVEEYSINSCLTLLCSLNGCSITTSDGLGNTEKGFHPIHKRFAGFHASQCGFCTPGMCISLYSALSKAHNSQSSPDYLTALAAEKSIAGNLCRCTGYRPIADACKSFASDVDIEDLGFNSFWRKGESREEMLKKLPPYNPEKDLITFPDFLKEKIKCQHNVLDQTRYHWSTPGSVAELQEILATTNPGKDRGLIKLVVGNTGTGYYKEEKQYGRYIDISHIPEMSMIKKDDREIEIGAVVTISKVIDALMEENTSAYVFKKIGVHMEKVANHFIRNSGSIGGNLVMAQSKSFPSDITTLLLAADASVHMINAGRHEKLRMGEYLVSPPILDTKTVLLKVHIPRWIASSTTGLLFETYRAALRPIGSALPYINAAFLAVVSHDASSSGIIVDKCRLAFGSYGGYHSIRAREVEDFLTGKILSHSVLYEAVRLLKGIIVPSIDTSYSEYKKSLAVGFLFDFLYPLIESGSWDSEGKHIDGHIDPTICLPLLSSAQQVFESKEYHPVGEAIIKFGAEMQASGEAVYVDDIPSLPHCLHGAFIYSTKPLAWIKSVGFSGNVTPIGVLAVITFKDIPEVGQNIGYITMFGTGLLFADEVTISAGQIIALVVADTQKHADMAAHLAVVEYDSRNIGTPVLSVEDAVKRSSLFEVPPEYQPEPVGDISKGMAEADRKIRSVELRLGSQYFFYMETQTALALPDEDNCLVVYSSTQAPEFTQTVIATCLGIPEHNVRVITRRVGGGFGGKAIKSMPVATACALAAKKMQRPVRIYVNRKTDMIMAGGRHPLKITYSVGFRSDGKLTALDLNLFIDAGSDVDVSLVMPQNIMNSLRKYDWGALSFDIKVCKTNLPSRTSLRAPGEVQGSYIAESIIENVASSLKMDVDVVRRINLHTYESLRKFYKQAAGEPDEYTLPLLWDKLEVSADFRRRAESVKEFNRCNIWRKRGISRVPIIHLVIHRPTPGKVSILNDGSVAVEVAGIEVGQGLWTKVQQMVAYGLGMIKCEGSDDLLERIRLLQTDTLSMSQSSYTAGSTTSENCCEAVRLCCGILVERLRPTMNQILENARSVTWDMLIQQANAQSVDLSARTFYKPESSSAEYLNYGVGASEVEVDLVTGRTEIIRSDIIYDCGKSLNPAVDLGQIEGAFVQGIGFFMYEEYTTNENGLVNEEGTWDYKIPTIDTIPKQFNVQILNSGHHKNRVLSSKASGEPPLLVAASVHCATRSAIREARKQYLSWNCIDDDHRERCDLGFELPVPATMPVVKQLCGLESIEKYLEWKTYP
What is the function of this protein?
Aldehyde oxidase with a broad substrate specificity (PubMed:28188272).  Involved in the accumulation of benzoic acid (BA) in siliques (PubMed:19297586).  Delays and protects siliques from senescence by catalyzing aldehyde detoxification in siliques.  Catalyzes the oxidation of an array of aromatic and aliphatic aldehydes, including vanillin and the reactive carbonyl species (RCS) acrolein, 4-hydroxyl-2-nonenal (HNE), and malondialdehyde (MDA) (PubMed:28188272).
What are the official names of this protein?
Aldehyde oxidase 4, AO-4, AtAO-4, AtAO2, Benzaldehyde oxidase, Indole-3-acetaldehyde oxidase, IAA oxidase.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAMP1_HUMAN
Sequence: MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
What is the function of this protein?
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane.  Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
What are the official names of this protein?
Receptor activity-modifying protein 1, Calcitonin-receptor-like receptor activity-modifying protein 1, CRLR activity-modifying protein 1.
What is the protein family that this protein belongs to?
Belongs to the RAMP family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.