PharMolix/UniProtQA huggingface dataset:
Protein: RPOB_STRPB
Sequence: MAGHEVRYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFQDFLDSGLKEVFEDVLPISNFTDTMELEFVGYEFKEPKYTLEEARIHDASYSAPIFVTFRLVNKETGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVIPNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIVDIFGESDLVRNTIEKDIHKNPSDSRTDEALKEIYERLRPGEPKTADSSRSLLIARFFDARRYDLAAVGRYKVNKKLNIKTRLLNQIIAENLVDAETGEILVEAGTEMTRSVIESIEEHLDGDLNKFVYTPNDYAVVTEPVVLQKFKVVSPIDPDRVVTIVGNANPDDKVRALTPADILAEMSYFLNLAEGLGKVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNDVLTPQQIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSSFGHLNKYGFIQTPYRKVDRATGRVTNEIVWLTADEEDEYTVAQANSKLNEDGTFAEEIVMGRHQGNNQEFSASVVDFVDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLIDPKAPYVGTGMEYQAAHDSGAAVIAQHNGKVVFSDAEKVEIRRQDGSLDVYHITKFRRSNSGTAYNQRTLVKVGDIVEKGDFIADGPSMENGEMALGQNPVVAYMTWEGYNFEDAVIMSERLVKEDVYTSVHLEEFESETRDTKLGPEEITREIPNVGEEALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGGDGIVRDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIHIATPVFDGASSEDLWDTVREAGMDSDAKTVLYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVLQEILTYKSDDVTGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDNEVELRDLDEGEDDDIMHVDDLEKAREKQAQETQEVSETTDEK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: ARGB_PARMW
Sequence: MPEPIQSGDDALRVSVLSEALPYIQRFSGRRIVIKYGGAAMAHAELREAVFRDLALLACVGVQPVVVHGGGPEINQWLKRLEIPAEFRDGLRVTDADTMDVVEMVLVGRVNKQIVNGLNQLGTRAVGLSGSDGSLVEARPWGDGSHGLVGDVARVNPDVLEPLLERGYVPVISSVAATPGDGRAHNINADTVAGELAAALEAEKLILLTDTPGILRDRDNPNSLIRKLRLSEARQLIDDGVVAGGMTPKTECCIRALAQGVSAAHIVDGRVPHALLLEVFTDAGIGTMVVGRG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZUR_PSEFB
Sequence: AECKTTIDSTDQMSFNTKAIEIDKACKTFTVELTHSGSLPKNVMGHNLVISKQADMQPIATDGLSAGIDKNYLKEGDTRVIAHTKVIGAGEKDSLTIDVSKLNAAEKYGFFCSFPGHISMMKGTVTLK
What is the function of this protein?
Transfers electrons from cytochrome c551 to cytochrome oxidase.
What are the official names of this protein?
Azurin.
What are the subcellular locations of this protein?
Periplasm.
Protein: MFRN1_HUMAN
Sequence: MELRSGSVGSQAVARRMDGDSRDGGGGKDATGSEDYENLPTSASVSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRSAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRAPY
What is the function of this protein?
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.
What are the official names of this protein?
Mitoferrin-1, Mitochondrial iron transporter 1, Mitochondrial solute carrier protein, Solute carrier family 25 member 37.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PORD_METJA
Sequence: MVTIAAIIYEPGNSIKNKTGTWRTFRPILDNEKCVKCENCYIFCPEGAIQEDENGNFKIDYDYCKGCLICMNECPVNAITKVREEK
What are the official names of this protein?
Pyruvate synthase subunit PorD, Pyruvate oxidoreductase delta chain, POR, Pyruvic-ferredoxin oxidoreductase subunit delta.
Protein: Y789_TREPA
Sequence: MKRIAYVPLCAVVGGMCSMWAQSATDVMGSFKKTAETGTMGTQARMVVRKAGKTVSTLVLKQYTRYEKSGEQKTLIEFLSPLSVRGTRFLSLQKKDGAWEQYLYLPKLARVRSITGGDAHASFMGTDFSYHDLSLVGGVADLDECTLDGTESYGGKMCVRIQTLSHKPQARYVRALLWIEQETGRFVKGEFFDKKDKRVKIMTLSDYETIQGVDTPKTVVLETIAQRSTTTIHLTKVEYHMDIPEKVFTPEYLTQTDR
What are the official names of this protein?
Uncharacterized protein TP_0789.
Protein: CTAA_BRASB
Sequence: MTTVPRTTDLAAIRIWLTVVAGLIALMVLVGGATRLTESGLSIVEWKPVTGTLPPLSERAWTDAFEAYKTIPQYRQMNAGMTLHEFKTIFWWEWGHRLLGRVIGMVYLLPFLWFLWRGAVSGPLGRRLWLIFGLGALQGAVGWWMVASGLTERTEVAPVRLATHLSLALLIFAAIVWTLRRLAPRAEAEVPARLRLTAWGLVGVTFVQLYLGALVAGLRAGLVYNTWPDIDGGLIPKAANLWIQSPWWINLFENDLTVQFMHRMTAYTLFLLGAWHAFDVMRAGAGRTVVRGAHRLLAAILVQAGLGIATLLMVVPISLALLHQGTAIIVLTFAVLQAERLSPRRVAAVVVPQAAVAAGQAG
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DACH2_MOUSE
Sequence: MAVSAPPVISATSSSAGVPGGLFRAEPLYSSPGEPPRLTPNMINSFMANNHNGSVLGGGIGGGSGGSSNTNTNECRMVDMHGVKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMTRKQAVNSSRPGRPPKRSLGVLQDNARLLPHAVPGLLSPGLITPTGITAAAMAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSTTGGSESSWDKDKIQSPLAASGPQHGIAHAALAGQPGLGGAPTLNPLQQNHLLSNRLDLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLSRAGASVIKERIPESPSPAPSLEESHRPGSQTSSHPSSSVSSSPSQMDHHSERMVMMPNNREELIVDQDNGQSIKKFQRDNKEEVPAQIPVMKSPLDKIQLAPGQALHPGFPGPFIFADSLSSVETLLTNIQGLLKVALDNARIQEKQIQQEKKELRIELFREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQEALEFESKRREQVEQALKQATSGDSGLRMLKDSGIPDIEIENSGTPHDSAAMQGGNYYCLAMAQQLCSA
What is the function of this protein?
Transcription factor that is involved in regulation of organogenesis.  Seems to be a regulator for SIX1 and SIX6.  Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter.  Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina.  SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3.  May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis.  In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression.  Probably binds to DNA via its DACHbox-N domain.
What are the official names of this protein?
Dachshund homolog 2, Dach2.
What is the protein family that this protein belongs to?
Belongs to the DACH/dachshund family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PIT1_MACMU
Sequence: MSCQAFTSADTFIPLNSDASATLPLIMHHSAAECLPVSNHATNVMSTATGLHYSVPSCHYGNQPSTYGVMAGSLTLVFYKFPDHTLSHGFPPIHQPLLAEDPTAADFKQELRRKSKLVEEPIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEQNKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR
What is the function of this protein?
Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary.  Activates growth hormone and prolactin genes.  Specifically binds to the consensus sequence 5'-TAAAT-3'.
What are the official names of this protein?
Pituitary-specific positive transcription factor 1, PIT-1, Growth hormone factor 1, GHF-1.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: FABZ_LISW6
Sequence: MLDIKKIKEILPHRYPFLLVDRVISVEEGKKVTAIKNVTANEEFFNGHFPEYPVMPGVLIVEALAQTSGIAMMQSEANKGKIGLFAGIDGCRFKRQVIPGDQLLLEAEITRMRGAIAKAKVKATVEGDLVCEAEIMFALSDLPK
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAD1_PONAB
Sequence: MPLLTQQIQDEDDQYSLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFKVQEESVTFRINLTVLLDCLSIFGSSPMPGTLTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMEAFHCNQTQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPESES
What is the function of this protein?
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.  The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex.  Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER).  The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates.  The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.  Possesses 3'->5' double-stranded DNA exonuclease activity (By similarity).
What are the official names of this protein?
Cell cycle checkpoint protein RAD1, DNA repair exonuclease rad1 homolog.
What is the protein family that this protein belongs to?
Belongs to the rad1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CDD_KLEP7
Sequence: MHSRFQAALTTLAADLQAAIAPMLADPHFPALLEADQVATLQHATGLDEDALAFALLPLAAACARPDLSHFNVGAIARGVSGRWYFGGNMEFLGATMQQTVHAEQSAISHAWLRGETSLRAITVNYTPCGHCRQFMNELNSGLALRIHLPGREAHALEHYLPDAFGPKDLEIKTLLMDEQDHGFPVSGDALTQAAIQAANRCHAPYSHSPSGVALELKDGTIFSGSYAENAAFNPTLPPLQGALNLLSLNGYDYPAIQRAILAEKADAALIQWDATVATLKALGCHNIERVLLG
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: P5CR_VIBAL
Sequence: MEHKKIAFIGAGNMVRAIVSGLVANGYPAQNITATAPSEARRLPLEQDFGIRTTSDNIQAATEADVVVLSVKPQMMADVCKPLQAIDFTNKLVISIAAGINCSRLDDMLATKLNLVRVMPNTPSQLGLGMSGLFAPIHVTEHDKAFAAELMEAVGKVCWVEQESGINNVIAAAGSAPAYFFLFMEAMQAEAIAQGFDKESARLLVQQAALGAASMVVSNPETELSTLRENVTSKGGTTAEALRTFNEHQLSDIVAKAMQAAVARAEEMEKLF
What is the function of this protein?
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase, P5C reductase, P5CR, PCA reductase.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTMB_NEOFI
Sequence: MPPAPPDQKPCHLQPAPYRALSETILFGSLNEERWWHSTAPILSRLLISSNYDVDVQYKYLSLYRHLVLPALGPYPQRDPETGIIATQWRSGMVLTGLPIEFSNNVARALIRIGVDPVTADSGTAQDPFNTARPKGYLETAARLLPGVDLTRFYEFETELVITKEEEAVLQANPDLFKSPWKSQILTAMDLQKSGTVLVKAYFYPQPKSAVTGRSTEELLVNAIRKVDRESRFETQLANLERYMERRRRGLHVPVVTADKPPPTEADKTFDACSFFPHFLSTDLVEPGKSRVKFYASERHVNLKMVEDIWTFGGLRRDPDALKGLELLRHFWADIQMREGYYTMPRGFCELGKSSAGFEAPMMFHFHLDGSQSPFPDPQMYVCVFGMNSRKLVEGLTTFYRRLGWEDMASHYQGNFLANYPDEDFEKAAHLCAYVSFAYKDGGAYVTLYNHSFNPLGDVALAN
What is the function of this protein?
Brevianamide F prenyltransferase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities (PubMed:23109474).  The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmPS/ftmA (By similarity).  Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B (By similarity).  The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively (By similarity).  The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (By similarity).  FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B (By similarity).  Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties (By similarity).  Finally, verruculogen is further converted to fumitremorgin A by the verruculogen prenyltransferase ftmPT3 (PubMed:23109474).
What are the official names of this protein?
Tryprostatin B synthase, Brevianamide F prenyltransferase, Fumitremorgin biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: XGPT_SALTI
Sequence: MSEKYVVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVIDIPQNTWIEQPWDMGVVFVPPISGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MSCL_BURP1
Sequence: MSIIKEFKEFAVKGNVMDLAIGVIIGGAFSKIVDSVVKDLIMPVIGVLTGGLDFSNKFVLLGQIPASFKGNPESFKDLQAAGVATFGYGSFITVLINFIILAFIIFLMVKFINKLRKPEEAAPAATPEDVLLLREIRDSLKQR
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TIG_STACT
Sequence: MTATWEKKEGNQGVLSVTVPAKKVDQAIDQAFKKVVKQVNIPGFRKGKVPRQIFEQRFGVEALYQDAVDILLPEAYGEAIEETGIKPVDQPEIEVNQIEKGKDLKFDATVTVQPEVKLGEYKGLEIEKQNADLTDEELQEAIDHSLGHLAEMVIKEDGSVEEGDTVNIDFDGYVDGEQFEGGQAESYDLEIGSGMFIPGFEEQLVGLKTGDEKDVKVTFPEEYHAEELAGKEATFKVKINEIKYKNVPELDDEIANELDSDADNVEEYKENLRKRLSEEKKVNAENVEKEEAINKAVNNAEVDIPEAMINNELDRMMQEFAQRIQQSGLNLETYFQISGQDESQLREQMKDDAEERVKTNLTLNAIANAEEVEATEEDIDKELEAMSTQFNISVEDIKKTLGSTDIVKDDVRVKKVIDLLLDDAKLVEPSEDAEEESEDK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: Y360_HAEIN
Sequence: MLDLLLEPFSYDYMLKAMILSTAVGGICAFLSSYLMLKGWSLIGDALSHSVVPGVAIAYAFALPYALGAFFAGILAALSILWIKSISKLKEDAVIGFIFSTFFALGLLIVSLNPTAVNVQNIILGNILGIADEDIYQVAIIIGVCLVLLLLFWKDLLLIFFDETQAITVGLSPLFYKILFFTLLSACVVAALQTVGAILVIAMVVTPGATAYLLTDKFKTLSIIAIILGAVTSFVGVYISYYLDGATGGVIVTLQTLLFLVAFLFSPKYGLLTRNKKAVENV
What is the function of this protein?
Part of an ATP-driven transport system HI_0359/HI_0360/HI_0361/HI_0362 for iron.
What are the official names of this protein?
Probable iron transport system membrane protein HI_0360.
What is the protein family that this protein belongs to?
Belongs to the ABC-3 integral membrane protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAA_ECO81
Sequence: MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADAPQLRFEVGTKPVTQTPQAAVTSNVAAPAQVAQTQPQRAAPSTRSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIPA_VIBCM
Sequence: MQELRFVLIIVGALAIAALLFHGLWTSKKEGKSKFGDKPLRKMKVESDDPPSRAFAAEDDFEIIRKERKEPDFGIPNQQHDPLISDFAAHDELDEEEDEEARIPVQPQSQPQPRKVQPQVEMPRVAPNVPMAKVQPEVVTEIEVQEPQEEKLDVIVLNVHCAGNQPFIGTKLFDSMQQNGLLFGEMDIFHRHADLSGTGKVLFSVANMMQPGTLMHDDPADFSTKGISFFMTLPCFGDPEQNFKLMLKTAQQIADDLGGHVLDDARNLMTPNRLDAYRKQIQEFKVRAAQA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: NCTB_ASPFU
Sequence: MSDREFSSNDDLSLPKATVQKIITEILPPSSGQTFSKDARDLLMECCVEFITLISSEANDISEKEAKKTIACEHVERALRDLGFGDYIPEVLAVAEEHKEQLKSREKKQSKMEQSGLTEEELLRQQQELFRSATEKYNAAPE
What is the function of this protein?
Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B (PubMed:31969561).  The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter (PubMed:31969561).
What are the official names of this protein?
NCT transcriptional regulatory complex subunit B, Negative cofactor 2 B.
What is the protein family that this protein belongs to?
Belongs to the NC2 beta/DR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UL87_HHV7J
Sequence: MIDSISEETLIVKSYTVNHCAKNVPVFINSYDLTAEVAKNEDVRLARQVQISLEKIDEVIESIFSASGPSVENVKDQAKFALCRLLLGPVSIPCYCEEWDVNFYLTKCSYNCEGPVLYIYKNASQCCESTYRFSIMTNYHSTHIFRGLLSLQEWNSHLSNILCTCSNVTGDKYTATIFPNNASIYLEYYPYFLCYLCKHLSIIDIEQCTNELIAFLGPKTSQRIIIHYKLLFGFRSKPMNFTVSLLEQVFTLEIQKLYYSVSKHNSTTADFFNVITAKFAEDKYFVLRTFKLSAQITPGIQSFCSLKFKLQTLYLNLKIMKNTKLSISNSFYHGKTLYTLDEKQLVWRNLLLIYYGYNLKDNVKQTQEESLLSMHYIRILERLSLKSFREINQQFSFEIPSYQEKTLQFIPGGNDFAEITSVTHGETTVNAFNTNRVMNVKAALSGEIHCVLHRIPKSMTHSFVMYKRTFKEPSLTVSTFISNDDFTTSSLNINIRGPYCDFLYALGVYRLHVNIQDFFLPAFVCNSNNSMDLHGLENQGIVRKRKKKVYWITNFPCMISNSEKVNVGWFKAGTGIIPKVSGTDLKNVLLKELISIGEIPNITFDMDLHALLTLLEKRNMHQVPFLIKQFFMFLRLGLLVGYGRKQERKVHHIMLFLIQKGFFDFSKNSVANSKIKHACALVGSRLANNVPKILSKQKKMKLDHLGRNANALTVLRFIVENGYYKRKTIFRKLLKYLATTSFNAHVQTESNRLLNLMHNDSKTNFSSLERLYTLR
What are the official names of this protein?
Protein U58.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL87 family.
Protein: SDHF3_CANGA
Sequence: MIGRRQLVTVFRRYASQNGVIGQDHTLLPPLMLYRRILRAHKLLPPMQKEMGDKYVKSEFELHRTIDNPLHIVGFLASWQDYLHQITNGKWKEGSLSPAVLEKMSPEQVGQLYELMKETEKVTKGDNPEEDKGKNKI
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants.  May act together with SDHAF1.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 3, mitochondrial, SDH assembly factor 3, SDHAF3.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family. SDHAF3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SYT_BUCAT
Sequence: MPVIRFYDGSQQVYEHSVSLIEIIKNKKPSIMKSLIAISVNNHFSNLNTFIREDAFIEFVDQKNYKALNIIRYSCAQLLSYAIKNIWPLAQIATSNIIEDGFYCDIDFKRSISEKDLILLENQMKTLVKREYNILNKLISYSEAREIFQKCFEKYKVSLIDENIHCNSKVSLYYHENYADIDIGLQVFNIKFCKYFKLQKIGGVYWKKNKNNKMLQRIYGTAWTNKQELDKHLDYLNELEKRDHRKIGKFLQLYHMQEESPGMIFWHNKGWIIFNELQNFVRVKLKEYKYEEVKTPLLIDKLIWKQSGHWDNYKNAIFTTLSEHREYCIKPMNCPGHVQIFNSRLKSYRDLPIRMAEFGSCHRNEPSGSLHGLMRVRNFTQDDAHIFCTREQVRSEINDCIKMIYDLYSTFHFKKILVKLSTRPEKRIGTDSLWNESEKDLSDMLIENHLSFEYQSGEGAFYGPKIEFILQDSLDRNWQCGTIQLDFYLPLRLSSFYINEKNEKKVPVIIHRAILGSIERFIGILIEECSGNLPTWLSPVQVVIISITDISSGYVKELFKKFSDVNIRIECDLRNEKIGFKIREHTLRRIPYILICGEKESSSKKISVRNRQGHNFGMIDVDFFIKKLQKEIITRNFYQMEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.