PharMolix/UniProtQA huggingface dataset:
Protein: CLPS_SHESW
Sequence: MGKTGNIEHVEERVESELMPPSMYKVILNNDDYTPMDFVIEVLQVFFRKNEQEATDIMLTIHHQGKGICGIFPFGIAETKVIQVNQFARQNQHPLLCSLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: Y252_SIRV1
Sequence: MNKVEVSVRKKLNNLPKVFLDIYLNKFTLDKNYINCVHYVSRSGLTQEGCVTGYTVGSMLKIDTLKEVKGIYYVPHPSIINITFRQKAIRNLDDLKQFLMSLDVSKISPRQPWLLVKYSNYSIEVFDIYFKGLIYEFPLLAEQGHLRIYSVPEPKDVYLLYYDNDGQKREINKELFTEVSEFMIFNHKVTFDKSILMFKNLYVTPGSGTLLYVPEDVHVKLESSDHKEVEVNVNRDTWLLFSHTRPRRSGQD
What are the official names of this protein?
Uncharacterized protein 252.
Protein: RIMP_RUEPO
Sequence: MTNNLIAKAAIDRRLAEIVSPVIADLGYELVRIRLMSGKSTTLQIMADKPDGGIEVDDCAAISNAVSATLDVEDPILDAYTLEVSSPGIDRPLTRLKDFEMFEGYEAKIETTEMIDGRRRFRGELAGIEGNEVLINLDQNGETVTIGLEFDWLSDAKLVLTDDLIKEMLRQRKAAGVLNEDQFDEIVEEAPETGATTMARDGSEEETK
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDPA_YERP3
Sequence: MSLDIDQIALHQLIKRDEQTLDVVLRDSLLPTNAVVEEMMAELHRVYSAKSKAYGLFNEQSELADALKRSRKGDEDFLSFSRAATGRLRDELAKYPFAEGGVVLFCQYRYLAVEYLLISVLSSCHSMRVNEQLDLSTTHYLDINRADIVARIDLTEWETNPESTRYLTFLKGRVGRKVSDFFMDFLSAAEGLDTKAQNRGLLQAVDDYCADAELGKNERQAYRQQVYSYCNEQLQAGEEIALQVLAQELPKLGEKDFQQFSAEQGYALEESFPADRGTLRQLTKFAGSGGGLSINFDALLLDERIFWDAATDTLTIKGTPPNLRDQLQRRAGSK
What are the official names of this protein?
Nucleoid-associated protein YpsIP31758_2721.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: Y602_GEOSW
Sequence: MDEIRYPIGKFQAPAAFCEEDAKQWISDIRQIPAKLWEAVSGLNEEQLNTPYRDGGWTVAQVVHHIADASMNAFLRTKWTLTEDVPSIKPFEENDWAKTTEARSLHIEPSLQLLEGLHERWAHLLESMSSDDFQRNFYHEGTKENVPLYVLIAMHAWHGKHHTAQIVSLRQRKGWN
What is the function of this protein?
Possible metal-dependent hydrolase.
What are the official names of this protein?
Putative metal-dependent hydrolase GWCH70_0602.
What is the protein family that this protein belongs to?
Belongs to the metal hydrolase YfiT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2079_STRMU
Sequence: MGFTDETVRFNLDDGNKKEISETLTHVYRSLEEKGYNPINQIVGYVLSGDPAYVPRYNDARNQIRKYERDEIVEELVRYYLQGNGIDLK
What are the official names of this protein?
UPF0297 protein SMU_2079c.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: RS18_CLOK5
Sequence: MANREGGRRNSGKLRRAKRKVCAFCMDKSEFIDYKDINKLRKYVTERGKILPRRISGNCAKHQRELTRAIKRARNIALLPFTTE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: ACCD_STRP8
Sequence: MALFRKKDKYIRITPNNFLKGSVSHNVPEVPDELFAKCPACKHMIYKKDLGLAKICPTCSYNFRISAQERLTLTVDEGSFQELFTSIETKDPLRFPGYQEKLQKAKETTGLHEAVLTGKAMVKGQQIALAIMDSHFIMASMGTVVGEKITRLFELAIEENLPVVIFTASGGARMQEGIMSLMQMAKVSAAVKRHSNAGLFYLTILTDPTTGGVTASFAMEGDIILAEPQSLVGFAGRRVIETTVRENLPDDFQKAEFLQDHGFVDAIVKRTELRDKIAHLVAFHGGGQ
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSB_XANCB
Sequence: MQPPSFSTSEDTVQPVSAASPIASDDASSAFVVAVPARYASTRLPGKPLQLIGDRPMIQHVADRALAAGAREVWVATDDARIAEAIQGLAGVRVAMTSSVHLSGTDRLAECARIAGWDAATCVVNLQGDEPFAPAAGIRAVAQVLQRSGAEMATLAAPVDSAHDLFDPNVVKLVRNAHGDALYFSRAPIPWHRDSFAGQRDAVPAGNHWLRHIGIYAYRAGFLQQFAAMPPGTLERIESLEQLRVLEAGYRIAVALTPEQFPPGIDTPEDLQRAQAQLASA
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUB2_YEAST
Sequence: MSHEGEEDLLEYSDNEQEIQIDASKAAEAGETGAATSATEGDNNNNTAAGDKKGSYVGIHSTGFKDFLLKPELSRAIIDCGFEHPSEVQQHTIPQSIHGTDVLCQAKSGLGKTAVFVLSTLQQLDPVPGEVAVVVICNARELAYQIRNEYLRFSKYMPDVKTAVFYGGTPISKDAELLKNKDTAPHIVVATPGRLKALVREKYIDLSHVKNFVIDECDKVLEELDMRRDVQEIFRATPRDKQVMMFSATLSQEIRPICRRFLQNPLEIFVDDEAKLTLHGLQQYYIKLEEREKNRKLAQLLDDLEFNQVIIFVKSTTRANELTKLLNASNFPAITVHGHMKQEERIARYKAFKDFEKRICVSTDVFGRGIDIERINLAINYDLTNEADQYLHRVGRAGRFGTKGLAISFVSSKEDEEVLAKIQERFDVKIAEFPEEGIDPSTYLNN
What is the function of this protein?
ATP-binding RNA helicase component of the TREX complex involved in transcription elongation and required for the export of mRNA out of the nucleus.  SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly.  May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.
What are the official names of this protein?
ATP-dependent RNA helicase SUB2, Suppressor of BRR1 protein 2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: AMPA_BURO1
Sequence: MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDMDGKRGKTLFLHEVSGIGASRVLLVGLGKQDAFNQKAYNDAATTAWRALLATKVVQVTFSLAQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASHTLKRVVFSVDPADEKAAKVAIKQAVALANGMDLTRDLGNLPGNVCTPIYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGSFLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKINVVAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLFSTNDALAGELLDASREANDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGGAAKGATGRPVPLLAQFLIDRAGQ
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
Protein: METK_VEREI
Sequence: MANDFLFTSESVSEGHPDKVADQISDAILDALLRQDPRSRVAAETLTNTGLVVLAGEISTNAHVDYIQVARDTIRRIGYDDTDYGIDYKGCAVLVAYDKQSNDIAQGVDHASDDHLNTGAGDQGLMFGYACDETPELMPAPIYYAHRLVERQAQLRKDGRLPFLRPDAKSQVTLRYVDGKPHSIDTVVLSTQHHPDQSATATTMKQSFIDAVIEEIIRPVLPKEWLHDTRFLINPTGRFVTGGPQGDCGLTGRKIIVDTYGGACPHGGGAFSGKDPTKVDRSAAYAARHVAKNVVAAGLARQCQIQVAYAIGVAEPMNITVYTEGTGVIADERIAALIKQHFDLRPRGIIQMLDLLRPIYEKTAAYGHFGREEPEFTWERTDKAAALRAAAGLSPGEHHRKEG
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED26_DROME
Sequence: MNQIEIQELTTHLSQALDQNYDVVNMDAVLCVICALEGTTITKEQLEATRLAKYINQLRRRTKNEHLARRAKSLLKKWREMVGIQQTATENLAHPSQISSSQPALDLVKSPITSFITEPIAPSQQIVSDLHSNIDSAEPPLSGEHTLLHPNFSNLVNSIKDSDRHENIAITTLHTHKDRRHSHSIRSCHVASPQPIVIDHSVNSVINLTDDSTVKINEASVVIDIASDSDENDNNGSLNPKKLNSIVPAPLPIPSTPSSRQRKLKKEKRSKEREGQVATNTRFGAKASDGFQQAALTTDSEIFSLSNSSMSSIVSGDATSSYSQNKSRLNSNELTFTGRFKAVDHLFRSTESGKHKIDEYSAYDSNASCSRLSPSTVDEVKKAEHLFDAQLTNTTANQIPMSAVSIGYESNTRHEYLESDSPSQIPKRRGRKKGSKGVDALIAKESSSLSQQIFFGGSTVKKVKTTKELFNEIQSRKLSVSMQSSASNLSNSSTNRDLPSHTTFPRQTSSCSDTSMNSPHILETLSGSAIFASKIDDLGNTDSDTVTSDPSHDSNKSQEIKECTSLDSNSNSIQSLPLANNRENLIPTNVNDITTQLMHLIHSLNSPLSEIEIERVYQEKIIPCTCIVIEGVQGTLGESNNSTLDEQSYNAKISLNSKDNLSCHNQDNYSTSQRSVNGEVIDTQPKLVKSIFDLDFDDNDDPLYFIMDEIQKPIARADELKNNKSDTKNINFGASAQNASLNIIHFNDDAQQDNSNQERGKNETQNAIPAFTVHEDPDCLARQRFYIQTNKVTSFHINALHNYYIPNINGNWDSVESFTSFQSEHTIMDTMESYTVTNGADVVPKYGLLTSDRIRKDLSSLKSIKPYRVKNFTSLISPFLGVAKCLPTCRRARRRFKNFVNSSTANDKISNNFESLENMKTSFKNCNPLNVKIDGTTSAIYSHNENHVPMQVNTNVEQLPPSQSFSSNAISYNLLKLADDKVCHDGISDKSSNTGCQGNSPYSSSSSSSYSGRKEDQHIITKNLQNKNIQLNSRKSDMKRRKRIYLENDSKKKKHYRKRIKTAVNRTFSNLHRNLYSIDSENGMKNDYKNEYGNSNNEEYAIVQRPAGDGENCSNHIVLTIKKTPSKINSPANSMTAFSPPSTSDGANLQKSILDLRLEDTNISQSITEIPQKKDLSKTDRIVHQSRSSAYRRIFRKPDKSQTKFIDLDLKHLFHLKANSPCISANAKLHNKLFFPHELSRDNTSGIRERLINYSSSSSSSYDDDSEVENTSFLKKANVNKFSASNNRNLKTETETCAATAISEFKFESDEDSILTSLGDSDIDIQDEIQVINDKVDYCNDFQNNKMLESFNSIFVDSLRTNTKNASDNMGSSAHITSLESLKPENADAITRYCNNNNLGVNLSNELSNISAKPLKSFDSTMKLPSLGIEHCTGIKTSSDMASTNIAEKKLTRIQQFKEWHQVLQLRSYNNEPLIVLPYVLLE
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).  Required for activated transcription of the MtnA gene.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 26, Mediator complex subunit 26, dARC70.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 26 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PAT_ECODH
Sequence: MNRLPSSASALACSAHALNLIEKRTLDHEEMKALNREVIEYFKEHVNPGFLEYRKSVTAGGDYGAVEWQAGSLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRKPFMPLLPGFRHVPFGNIEAMRTALNECKKTGDDVAAVILEPIQGEGGVILPPPGYLTAVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDMLLDGFRQLAREYPDLVQEARGKGMLMAIEFVDNEIGYNFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIEQCELVIKAARKALAAMRVSVEEA
What is the function of this protein?
Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline.  This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal.  Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Putrescine aminotransferase, PAT, PATase, Cadaverine transaminase, Diamine transaminase, Putrescine transaminase, Putrescine--2-oxoglutaric acid transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.
Protein: TVB16_HUMAN
Sequence: MSPIFTCITILCLLAAGSPGEEVAQTPKHLVRGEGQKAKLYCAPIKGHSYVFWYQQVLKNEFKFLISFQNENVFDETGMPKERFSAKCLPNSPCSLEIQATKLEDSAVYFCASSQ
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 16.
What are the subcellular locations of this protein?
Cell membrane.
Protein: PUTP_STAAS
Sequence: MLTMGTALSQQVDANWQTYIMIAVYFLILIVIGFYGYKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGAYINYFVVAPRLRVYTELAGDAITLPDFFKNRLNDKNNVLKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAMKPTNLNLFKGLSFIGIISLFSWGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAYHIKLEDPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAKTHQKEFVMIGRLSVLVVAIVAIAIAWNPNDTILNLVGNAWAGFGASFSPLVLFALYWKGLTRAGAVSGMVSGALVVIVWIAWIKPLAHINEIFGLYEIIPGFIVSVIVTYVVSKLTKKPGAFVETDLNKVRDIVREK
What is the function of this protein?
Catalyzes the sodium-dependent uptake of extracellular L-proline (By similarity).  Since most S. aureus strains are L-proline auxotrophs, this transporter may aid the bacterial persistence during an infection of tissues with low proline concentrations (By similarity).
What are the official names of this protein?
Sodium/proline symporter, Proline permease.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UBIE_PSEPU
Sequence: MNDQRKGDHAEPTTHFGYQDVPESQKAKKVAEVFHSVAAKYDLMNDVLSGGMHRLWKRFTIELSGVRAGNRVLDIAGGTGDLAAKFSRLVGPTGQVVLADINESMLKVGRDRLLDRGVAGNIEFVQADAEKLPFPDNHFDCVTIAFGLRNVTHKDEAIRSMLRVLKPGGRLLVLEFSKPTNKLMSKAYDAYSFAFMPLAGKLITNDSESYRYLAESIRMHPDQETLKAMMVEAGFDRVTYHNMTSGIVAVHRGIKP
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: FZD5_RAT
Sequence: MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGGECPSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHSHIHYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGVCYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGSDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESWRRFTSRCCCSSRRGHKSGGAMVAGDYAEASAALTGRTGPPGPAAAYHKQVSLSHV
What is the function of this protein?
Receptor for Wnt proteins (PubMed:20530549).  Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity).  In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549).  Functions in the canonical Wnt/beta-catenin signaling pathway.  The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity).  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).  Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).
What are the official names of this protein?
Frizzled-5, Fz-5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Synapse. Perikaryon. Cell projection, dendrite. Cell projection, axon. Note=Localized at the plasma membrane and also found at the Golgi.
Protein: NSP4_ROTWI
Sequence: MDKFADLNYTLSVITLMNDTLHSIIQDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVIKCCIVTIINTLLKLAGYKEQVTTKDEIEQQMDRIVKEMRRQLEMIDKLTTREIEQVELLKRIHDNLIIKPVDVIDMSKEFNQKNIKTLDEWESGKNPYEPLEVTASM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: ATP23_VANPO
Sequence: MSKNADLEAIPAAEEIKKPNPPKEEASIKGFTWWRRTLQYNTGLGLSEDEKLNYENDYKYILERKQCKQCYEYKDWILKYSPTVTFMIQQIAKLSDGNPNIDGKNLKPFDESKIICDICPEWKSGGFHPDLGILICQNRIRNKWHLEDTLAHELVHQFDNLKWKVNWLNLKQHACSEIRASSLSGECRFGQEFARRGFGFKIANGHQECVKRRAILSVMGNPNCKDRAEAELVVNEVWDSCFNDTRPFEEIYR
What is the function of this protein?
Has a dual role in the assembly of mitochondrial ATPase.  Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side.  Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring (By similarity).
What are the official names of this protein?
Mitochondrial inner membrane protease ATP23.
What is the protein family that this protein belongs to?
Belongs to the peptidase M76 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Associates loosely with the inner membrane.
Protein: DCA17_RAT
Sequence: MGRTRKANVCPRLSRRALGFYTRDAGVVQRTNLGILRALVCQESTKFKNVWTTHSKSPIAYERGRIYFDNYRCCVSSVASEPRKLYEMPKCSKSEKIEDALLWECPVGEILPDPSDYKSSLIALTAHNWLLRISATTGEILEKIYLASYCKFRYLSWDTPQEVIAVKSAQNKGSAAARQAGTQPPVLLYLAVFRVLPFSLVGILEINRKVFENVTDATLSHGILIVMYSSGLVRLYSFQAIIEQFMQQKLDLGCACSQGGTTGTVGEAPFGIPCNVKITDSPPPLFEVSSLENAFQIGGHPWHYIITPNKKKQKGVFHICALKDNSLAKNGIQEMECCSLESDWIYFHPDASGRIIHVGPNQVKVLKLSEVENNSSQHQISEDFVIWANREDRKENLITVTASGRVVKRNVNLLDDDPEQETFKVVDYEDELNLLSVVAVTQIDAEGKAHLDFHCNEYGTLLKSIPLVESWDVVCITTGTLSCKGFLYKRHLLGHVLVSPDSPVP
What is the function of this protein?
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
What are the official names of this protein?
DDB1- and CUL4-associated factor 17.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Nucleus, nucleolus. Note=Has been shown in human and mouse to be a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.
Protein: OMCB_CHLTH
Sequence: MNKLIRRAVTIFAVTSVASLFASGVLETSMAEFISTNVISLADTKAKDNTSHKSKKARKNHSKETPVNRKKVAPVHESKATGPKQDSCFGRMYTVKVNDDRNVEITQAVPKYATVGSPYPVEITATGKRDCVDVIITQQLPCEAEFVRSDPATTPTADGKLVWKIDRLGQGEKSKITVWVKPLKEGCCFTAATVCACPEIRSVTKCGQPAICVKQEGPENACLRCPVVYKINVVNQGTATARNVVVENPVPDSYAHSSGQRVLTFTLGDMQPGEHRTITVEFCPLKRGRATNIAMVSYCGGHKNTASVTTVINEPCVQVSIAGADWSYVCKPVEYVISVSNPGDLVLRDVVVKDTLSPGVTVLEAAGAQISCNKVVWTVKELNPGESLQYKVLVRAQTPGQFTNNVVVKSCSDCGTCTSCAEATTYWKGVAATHMCVVDTCDPVCVGENTVYRICVTNRGSAEDTNVSLMLKFSKELQPVSFSGPTKGTITGNTVVFDSLPRLGSKETVEFSVTLKAVSAGDARGEAILSSDTLTVPVSDTENTHIY
What is the function of this protein?
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane protein.  It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity).
What are the official names of this protein?
Large cysteine-rich periplasmic protein OmcB, serovars L1/L3, Large-CRP, 60 kDa CRP, 60 kDa outer membrane protein, Cysteine-rich outer membrane protein.
What are the subcellular locations of this protein?
Periplasm.
Protein: GLMU_FRATM
Sequence: MGLSVVILAAGKGSRMNSNKPKVLQTLAAKTLIEHVVSSVEKLNPDNIVVVTGHLKEQVEDALQGRNITFVYQQQQLGTGHAVLQALPYLKEQKVLILYGDVPLISTEVLENLVDTTNDDDLGVLTAFVENPQGLGRIVRDKFGAVTEIVEEKDANDIQRQIKEINTGIYCVHKNLLQKWLPEIKANNVQKEYYLTDIITFAKADHVSINVTHPINEFEILGVNDRTQLASLERVWQRNVAEKIMAKGVSIADPNRFDVRGNLDVGKDCWIDINVIIKGNVKLGNNVVIGANCILKNCIIEDNVRIKSNSMVDGSIIREGAIVGPFARVRPECDVKEGAVIGNFVEAKKTILGKGSKASHLTYLGDSEIGANCNIGAGVITCNYDGVNKHKTVIGDYAFIGSDSQLIAPVNIGQGATVGAGSTIVKDVPADNLAISRARQRHIDTWQRSVKKTDK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.