PharMolix/UniProtQA huggingface dataset:
Protein: RK10_TOBAC
Sequence: MEATFFTLPSSTSHSYPFSLKSHFNNSLTLPTHPHFKPKSKNLTIRSAISRTKKEETVETVKQQLEDCYLLAGIGYKGLTVKQFQELRSQLPDTTKLLVAKNTLVLKAIEGTKWEALKPCMKGMNAWLFVHSEEIPAALKPYRTFQKEKKLEENDFTGAVFEGKFYGPEEFKALETLPTRAEIYAQLLGSLKGPASAVVGTIQAPARNLVMVLKAYVKKLEEEGGSQ
What is the function of this protein?
This protein binds directly to 23S ribosomal RNA.
What are the official names of this protein?
50S ribosomal protein L10, chloroplastic, CL10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PFF1_AJEDR
Sequence: MATPRAQKFNPIAFTPGPVTLITTIVYLALLIPILVISLVVPPAPETSPEGVNLTEAWRDLQHLTGGFHPYNSRRNDDVHQWLLRRIDSILRPTVEAGERPSANNDIPDVFVFDDNQSNLTYSNGGVGKAAIVGVYFEGTNIIVYIRGTEDDPENWWERSNGKPKGKGGVLVNAHYDSVSTGYGATDNGMGVVSLLQLLKYFTTPGNKPRKGLVLLFNNGEEDYLNGAHVFSQHPLSNFTHTFLNLEGAGAGGRAALFRTTDTEVTRFYQNAKHPFGSVLAADGFKMGLLRSQTDYVVFNGILGLRGLDLAFIAPRSRYHTDQDDARHTSVDSLWHMLSAAIGTTEGLVSYTGTDFDGKSQGLDKVNSGTGTLGVWFDMFGSAFAVFRLHTLFALSVTLLIVAPLVIFITAIVLSKTDRMYLFSMSKSLGGTDERVSLRGLRGLFRTPIILAVATVIPIGLAYLLEKVNPYIVHSSQFSVWSMMISVWIFLAWFLACAADFFRPSALHRAYSYTWIFIATWVMLVINTVYANQKGIAAGYFVFFYFSGSFLATWVSYLELFALPRKGDFARQAIMHSGRPPSSLRSRLLTPSADELPSDTGPHAEYPGDADETDPTESTSLLRGQRTTFANYRTGGTDGVVEGTDEGPSFKHEQSWSWTLPRWTWVLQLLLLAPIVLILVGQLALFLTTSMSQVGSDGVSTFIVYLACAVFTTLLFAPLFPFIHRFTYHIPTFLFLVFVGTLIYNLVAFPFSPANRLKMFFIQEVNLDDGSNTVSLSGIQPYLTDAINSIPSAAGQNITCDQSAFGKLEKCSWAGLPPRVLGQDHDRDTGIVSSDWMSYNITKTVGENKARIEISGRNTRACKLKFDKPVADFQVSGSAVDHRMPHTSGQGVAEIRLWSRTWDRTWVVDICWHDSHDKPEDDDGDDEKQDAPRNGLSGKVICLWSDSNQSDVIPALDELRLYTPNWVAISKSADGLVEASHGITIQ
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: ARFK_ARATH
Sequence: MSQTSLEPLIISIIKLQILQLWLKLIAVGWNLGSNDDELYTELWKACAGPLVEVPRYGERVFYFPQGHMEQLVASTNQGVVDQEIPVFNLPPKILCRVLSVTLKAEHETDEVYAQITLQPEEDQSEPTSLDPPLVEPAKPTVDSFVKILTASDTSTHGGFSVLRKHATECLPSLDMTQPTPTQELVARDLHGYEWRFKHIFRGQPRRHLLTTGWSTFVTSKRLVAGDAFVFLRGETGDLRVGVRRLAKQQSTMPASVISSQSMRLGVLATASHAVTTTTIFVVFYKPRISQFIISVNKYMMAMKNGFSLGMRYRMRFEGEESPERIFTGTIIGSGDLSSQWPASKWRSLQIQWDEPSSIQRPNKVSPWEIEPFSPSALTPTPTQQQSKSKRSRPISEITGSPVASSFLSSFSQSHESNPSVKLLFQDPATERNSNKSVFSSGLQCKITEAPVTSSCRLFGFDLTSKPASATIPHDKQLISVDSNISDSTTKCQDPNSSNSPKEQKQQTSTRSRIKVQMQGTAVGRAVDLTLLRSYDELIKELEKMFEIEGELSPKDKWAIVFTDDEGDRMLVGDDPWNEFCKMAKKLFIYPSDEVKKMRSKSLLGDKGTIVNLESDQRTVHV
What is the function of this protein?
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).  Could act as transcriptional activator or repressor.  Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.
What are the official names of this protein?
Auxin response factor 11.
What is the protein family that this protein belongs to?
Belongs to the ARF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ERPA_COLP3
Sequence: MSNPELPIKFTDSAASKVLSLITEEENPALKLRVYVTGGGCSGFQYGFTFDEKVNDGDMTIEKQGVMMVIDPMSLQYLVDGEVDYLESLEGSRFVVNNPNATTTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: CCNE1_HUMAN
Sequence: MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
What is the function of this protein?
Essential for the control of the cell cycle at the G1/S (start) transition.
What are the official names of this protein?
G1/S-specific cyclin-E1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin E subfamily.
Protein: DNAK3_SYNE7
Sequence: MGRVVGIDLGTTNSVIAVMEGGKPMVIANAEGVRTTPSVVGVSKTGERLVGELARRQLVLNPRNTFANIKRFIGRRYDELTDESKRVPYTVRRDPEGNVRIVCPQLSREFAPEEVAAMILRKLAEEASRYLGEPVTGAVITVPAYFNDSQRQATRDAGRIAGLEVKRILNEPTAASLAYGLDRRDNQTILVFDLGGGTFDVSVLKVGNGVFEVKATSGDTQLGGNDFDRRIVDWLAEQFLEAEGIDLRRDRQALQRLIEAAEKAKIELSGVSVTDINLPFITATEDEPKHLETRLTRSEFEALCEDLLERMMRPLRRALKDARLQPQDIDEVVLVGGSTRMPMVQQLVRSLIGREPNQNVNPDEVVAIGAAIQAGILAGEVKDILLLDVTPLSLGLETIGGVMKKLIPRNTAIPVRRSDIFSTAENNQTMVEIHILQGERQLAEGNKSLGRFKLTGIPPAPRGVPQVQVSFDIDANGILQVSALDKTTGREQTVTIQGASTLSQEEVKRMMKDAELYAQQDRQLKARIEKRNRAQTLIAQSERRLREISLDFGLYFAESKRRRIESTIRELKDYLERQDDRGLDLALAELQDALFDLNQETAARLRDEEGEGFFEPLKQTFASLRGDGNRDFERSWDDRGGDRWDADPWDRSRRSTPSYGYDDRRSPVSDPYRGERWVEEQTSMSRREPVRDRNGGNGSVRPEPAPRRGRPTWEEDQPPRRDRSSQPPAKPASGRRWNDGWDDDDDEWF
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein dnaK3, HSP70-3, Heat shock 70 kDa protein 3, Heat shock protein 70-3.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ELK3_HUMAN
Sequence: MESAITLWQFLLQLLLDQKHEHLICWTSNDGEFKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDKNIIKKVIGQKFVYKFVSFPEILKMDPHAVEISRESLLLQDSDCKASPEGREAHKHGLAALRSTSRNEYIHSGLYSSFTINSLQNPPDAFKAIKTEKLEEPPEDSPPVEEVRTVIRFVTNKTDKHVTRPVVSLPSTSEAAAASAFLASSVSAKISSLMLPNAASISSASPFSSRSPSLSPNSPLPSEHRSLFLEAACHDSDSLEPLNLSSGSKTKSPSLPPKAKKPKGLEISAPPLVLSGTDIGSIALNSPALPSGSLTPAFFTAQTPNGLLLTPSPLLSSIHFWSSLSPVAPLSPARLQGPSTLFQFPTLLNGHMPVPIPSLDRAASPVLLSSNSQKS
What is the function of this protein?
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos.  Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
What are the official names of this protein?
ETS domain-containing protein Elk-3, ETS-related protein ERP, ETS-related protein NET, Serum response factor accessory protein 2, SAP-2, SRF accessory protein 2.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL15_ECO57
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEVRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ISPG_EXISA
Sequence: MSEILHRSLTRPVRVGNLIIGGSNEVIIQSMTTTKTHDVEATVAEIKRLEEAGCQVVRVACPDERAADALAEIKSRINIPLVVDIHFDYKLALKAIESGVDKIRINPGNIGRREKVEAVVNAAKAKGIPIRIGVNAGSLEKQFLEKYGYPTAQGMVESAMHHVKILEDLGFYNTIISLKASDVNLALEAYTLAAKTFDYPLHVGITESGPLFSGSLKSAAGLGAILSLGIGSTVRVSLSDDPVEEVKVAKEVLKSFGLAANAATLISCPTCGRIEIDLISIAKEVEEYIQNINVNIKVAVLGCAVNGPGEAREADIGIAGARNEGLLFRHGKIIRKVPEATMVEELKKEIDAIAAEKMAEREREEQELANQSN
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: GL82_ORYSJ
Sequence: MASSSFSFLLVAALLGLASWKAIASDPSPLQDFCVADLNSPVRVNGFVCKNPMNASADDFFKAAMLDKPRDTNNKVGSNVTLVNVLQLPGLNTLGISIARLDFAPLGLNPPHTHPRATEIFTVLEGTLYVGFVTSNPDNRLLSKVLNKGDVFVFPEGLIHFQFNPNPHKPAVAIAALSSQNPGVITIANAVFGSNPPISDDILMKAFQVDKKIIDLLQAQF
What is the function of this protein?
Plays role in broad-spectrum disease resistance.  Probably has no oxalate oxidase activity even if the active site is conserved.
What are the official names of this protein?
Germin-like protein 8-2, Germin-like protein 16, Germin-like protein 3, OsGER3.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: PUR7_CLONN
Sequence: MEKKMLYEGKAKKVYEAEDKDHVIIYYKDDATAFNGAKKSQIDHKGILNNNITSAIFEMLHEKGIETHFEKKLNEREQLCKKVEIVPLEVIVRNVAAGSMAKRLGVSEGKELNTTIFEICYKNDELGDPLINDYHAVALGLATFDELKEIYNITSNVNNILKEFFLKQNIKLIDFKLEFGRFNGKIILADEISPDTCRFWDATTNEKLDKDRFRRDMGNVEEAYIEILNRISNAK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: SEC18_CANAX
Sequence: MEKLGFHKVSNSPSSPSQPKITHNRPIPHPQSPPLPQRPLSEPLKKQLLVDNSPGNDVVIANCVAVNAQDFQNIPDRAPVILDGVFVYSIAKDDRVRPGTIGLAGNMRTWGKWSLGQPVNVENYNIFHNGQQQQYLGAIDLSIDFRAKARANSNPINHDELVALFLKNYENQILQPTQVIYMEYTGIYFQIRVNNVQIIDVNTKDQLPSFKDSDDINTKGILIKSTDVGFYPYEGSIINLTKPKTLKQRMFGGSTPHRTSRRKQIINPDFKLEDLGIGGLDAEFQDIFRRAFNSRILPPELAEKLDYKHCKGLLLYGPPGTGKTLIARKLSKMLNGKEPKIVNGPEMLSKYVGASEENIRNLFKDAEAEYKLKGEDSDLHVIIFDELDSVFKQRGSGKSDGTGVGDNVVNQLLSKMDGVDQLNNILVIGMTNRLDLIDTALLRPGRFEIQIEISLPDEKGRKDIFLIHTKKLTENGILSSDVNFDELSTLTKNFTGAEIEGLCNSAKSYAISRHTKKGALAQIDPESIAKMKITRDDFLLALNDIRPAFGTDEEDLSQQAQHGIIQFNQTIRNIFEKGQSIIDVVRSSETEHLRSILLYGPPGVGKTSIATTLALNSDFPFIKMLSAETLVGMGELRKIQEIDNVFRDVHKSPLNVLVIDKIENIINYNPIGPRFSNDILQVLMVYLTKKPPKGRRLLIIGTTSQYQVFKHMNLIDSFNDAIAVPPIKHIEEVGKVLDKLGFMNKSEREEILSQLSRYDINIGIKSLIDVLMVSKYSRDTVDEVVNNIVEKMSG
What is the function of this protein?
Required for vesicle-mediated transport.  Catalyzes the fusion of transport vesicles within the Golgi cisternae.  Is also required for transport from the endoplasmic reticulum to the Golgi stack.  Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
What are the official names of this protein?
Vesicular-fusion protein SEC18.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMGT2_MOUSE
Sequence: MHLSAVFNALLVSVLAAVLWKHVRLREHAATLEEELALGQQSLDPVLGLKIDYPKALQILMEGGTHMVCTGRTHTDRICRFKWLCYSNEAEEFIFFHGNSSVMLPNLGSRRFQPALLDLSTVEDHNAQYFNFVELPAAALRFMPKPVFVPDVALIANRFNPDNLMHVFHDDLLPLFYTLRQFPGLAQEARLFFMEGWGEGAHFDLYKLLSPKQPLLRAQLKTLGRLLCFSHAFVGLSKVTTWYQYGFVQPQGPKANILVSGNEIRQFTRFMTERLNVSHAGAPLGEEYILVFSRTQNRLILNEAELLLELAQEFQMKTVTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTALFLPRGATVVELFPYAVNPDHYTPYKTLATLPGMDLQYVAWRNMIRENTVTHPERPWDQGGITHLDRAEQARILQSREVPRHLCCRNPEWLFRIYQDTRVDIPSLMQSIRRVVKGRPGPRRQRWAISLYPGKVREARCQASVQGATEARLSVSWQIPWNLKYLKVREVKYEVWLQEQGENTYVPYMLTLQNHTFTENIKPFTTYLVWVRCIFNRSLLGPFADVLVCST
What is the function of this protein?
O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein (By similarity).  Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:24256719).
What are the official names of this protein?
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2, POMGnT2, Extracellular O-linked N-acetylglucosamine transferase-like, Glycosyltransferase-like domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 61 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: PYRF_ACIBT
Sequence: MEESLLSIIVALDAKSQYDALKIVEQLDPTLCRVKVGKELFTHEGPSVVKKLQEENFEVFLDLKFHDIPNTTAQAVCAAADLGVWMVNVHASGGRKMMETCVERLKAGNYQTQLIAVTVLTSMGREDLKDIGLDIEPVEQVKRLAKLTKESGLDGVVCSAQEAKILRELIGQDFSLVTPGIRPEGSNADDQKRIVTPKQAMLDGSTHLVIGRPITKAENPTEMLKSILASIA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: TX331_LYCSI
Sequence: MKFVLLFGVLLVTLFSYSSAEMLDDFDQADEDELLSLIEKEEARAKECTPRFYDCSHDRHSCCRSELFKDVCTCFYPEGGDNEVCTCQQPKHLKYMEKAAGKAKKFGGKIRKWFG
What are the official names of this protein?
U3-lycotoxin-Ls1o, Toxin-like structure LSTX-B31.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HUTH_DESPS
Sequence: MNSKIEIKPGRLTLAELRRMAKAPVGVRLEEKCKGKINASVQTVGEVIRQGRVIYGINTGFGLLANTIIPNEELEHLQRSLILSHAAGVGAFMADSTVRLMMVLKINSLARGYSGIRLEVIEALVQLLNAEVYPSVPQKGSVGASGDLAPLAHMSIVLLGEGEASYRGQRLSGREGLELAGLSPITLGPKEGLALLNGTQASTAFALQGLFAAEELFATAMVSGSLSLDAALGSRRPFNPLIHAVRGHKSQIDVAASYRQLLEHSEIERSHKFCEAVQDPYSLRCQPQVMGACLNQIRNAAEVIGTEANAVSDNPLVFCKENDIISGGNFHAEPIAMVADNLALAIAEIGALPERRTALLIDSHMSGLPPFLVDKGGLNSGFMIAQVTAAALASENKSLAHPASVDSLPTSANQEDHVSMATFAARRLLEMADNTAGILAIELLAACQGIDFRAPLKTSPLLEEAKSIVRQVVAFYDQDRYLAPDIKNAQALVQAGAFNHLVSRDLLPSFNR
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPIB_BACSU
Sequence: MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEKVHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLNFRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDALDRHDKEAFEQLSRQLNQLT
What are the official names of this protein?
UPF0302 protein YpiB.
What is the protein family that this protein belongs to?
Belongs to the UPF0302 family.
Protein: ARP3_RAT
Sequence: MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGVNAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
What is the function of this protein?
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility.  Seems to contact the pointed end of the daughter actin filament.  In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation.  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA.  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).  Plays a role in ciliogenesis.
What are the official names of this protein?
Actin-related protein 3, Actin-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Nucleus. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).
Protein: TFB5_ASHGO
Sequence: MPRARKGALVQCDPSIRALILQIDSGTHDIIWEELDETHLLVDPAKVSYIKEKLNWFLSKNIYNPSEEEENP
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH subunit TFB5, TFIIH subunit TFB5, RNA polymerase II transcription factor B subunit 5.
What is the protein family that this protein belongs to?
Belongs to the TFB5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MOAA_MYCSS
Sequence: MTVTPLGVPTISRPAAGMPTTGPLVDTFGRIATDLRVSLTDRCNLRCTYCMPAEGLDWLPGEQLLSADELIRLLRIAVTRLGITNVRFTGGEPLVVRHLEDVVAATGALRPRPEMAMTTNGIGLAKRARALKAAGLDRVNVSLDSVDAAHFARITRRDRLGDVLAGLAAAKEAGLTPVKVNAVLDPDTGLDDAVSLLRYCLDHGYQLRIIEQMPLDAEHQWQRGRSLEAAGILAALRAHFTLVPDSKPRGSAPAQLWRVDGGTATVGVIASVSEAFCAACDRTRLTADGQVRNCLFAREESDLRRLLRGGADDDAIEQAWRAAMWTKAAGHGINDPGFEQPSRPMSAIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: IMH1_ASHGO
Sequence: MFKQLSQFGKNITDELAKGINEDTASEGQHGAGAQGGRREEGGSPYEELPKEIQAKLRKFEKYEQKYPLLLNAYKAEKEKSDEVELLLKVLSENTPVSAIGDVETLRGFFEDVGVKTAMLTEEIKRITGENNGLQKQLAEAQESLEQRQRDLTSREEELAKSSREATELRELRQQAVAEKDAAVTERDDAQKAAAEMETRCTEAEAHAAEMKSQIESMETELKRTEKLLTTYKSTIQELGASQATGEAQPSSEAPSVRGKKGKGKRGKGKKRVQAADEKADTSSELELGEEKTPSTSSAGDEIIEAIETKQKYENLVEEHQQLSLELEKSRHWEQECLDSRKKVETLETELKDVKAKLKNSNEELETVRGMLKTVGNELVHARDELKQLNCEGTNEVERLKSELQELRTENSTQIATLKEQLQLLNDQKKALETDVEQHKRKMEDLESELLKSQENVSKFRNQNNDLSEKLRDYIVLKKSEATTRMSLSQKEKTIEYLEEQVRQYNSKEIEDKKAFADSKTELERWQRTAANLEKQLERIRLETKRHDDNLESYIKENGKLSERLEVLQEKYDSLQNLKSNSGDQVSAIRKQCEELNSKLKEATKRVMSLEDELNETSTVLQERTREATTMRRMINSDRSSKDTKIRELEDRVAAASEERDKLKSELDVLLARKNHETQDLKNTNQELVVKINALELKEQELATEVQQLKVLNQTIRRHSSTAADGSEELELTVRKLKDSLRTSEKKMRELKDSNEELKSLNDELNAKLDRLANRYKVLSTQLKMSKDMSSQSRHSSRSGSLVSPSSDNETGNSPRKISISSAHPAPVVASYDNSAEMESNEKLAYIRNVLLGFLEHREQRSQLLPVVSTLLQLSSHDEKRLLTSLK
What is the function of this protein?
Involved in vesicular transport between an endosomal compartment and the Golgi apparatus.
What are the official names of this protein?
Golgin IMH1.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein.
Protein: LPXK_PSEF5
Sequence: MALSDRLLNAWYNGHPALKLLRPLECLYRRVVTGKRQRFLAGEGAIYQPPVPLIVVGNITVGGTGKTPLILWLVEHCQRLGLRVGVVSRGYGAKPAQLPWRVSAEDCAAVAGDEPLLIVQRCGVPLMIDPDRGRAVQALLAAEPLDLILSDDGLQHYRLARDLELVLIDAARGLGNRRCLPAGPLREPAERLQSVDAVLYNGAVDDRDDGFAFHLKPSVLVNLRSGERRALEHFAPGQALHAVAGIGNPQRFFNTLETLHWRPVPHAFADHAQYSAQALTFTPSLPLVMTEKDAVKCRAFAADDWWYLAVDAQPSPAFVAWFDTQLMRLLPDRLLP
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: Y795_CLOD6
Sequence: MGRIGNIINRKGKQDAQRAKIFTKHARAIAVAAKEGGADPEYNAALKTAIEKAKADNMPNDNIDRAIAKGAGAGAGEDYETIVYEGYGPGGVAVIVETLTDNKNRTAGNVRYYFDKNGGNLGTSGCVSFMFDKKGQILVGLGDGVSEEELMDVALEAGAEDFITEEDGYEIITTPEDFSSVRDELKAKGYEFISADVKMIPQTTTVLTEESHLKMMNKLVDMLEEDDDVQDIYHNWEVE
What are the official names of this protein?
Probable transcriptional regulatory protein CD630_07950.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCPB_STRMT
Sequence: MSTLAKIEALLFVRGEDWIRVRQLAELLSLPPTGIQQSLEKLSQKYEKDLDSSLDLIETGGAYRLVTKPQFSEILKEYSKAPINQSLSRPALETLSIIAYKQPITRIEIDAIRGVNSSGALAKLQAFDLIREDGKKEVLGRPNLYVTTDYFLDYMGINHLEELPVIDELEIQAQESQLFGERIEEDENQ
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: CSN3_PONAB
Sequence: MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity).  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity).  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity).  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).  Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3.
What is the protein family that this protein belongs to?
Belongs to the CSN3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.