PharMolix/UniProtQA huggingface dataset:
Protein: ATPF_ECOSM
Sequence: MNLNATILGQAIAFVLFVLFCMKYVWPPLMAAIEKRQKEIADGLASAERAHKDLDLAKASATDQLKKAKAEAQVIIEQANKRRSQILDEAKAEAEQERTKIVAQAQAEIEAERKRAREELRKQVAILAVAGAEKIIERSVDEAANSDIVDKLVAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: HPRK_POLSJ
Sequence: MKPTVVSADVLFEDHRAALKWQWVAGLGASERRFDEVAVRAARSGADLVGYLNYIHPYRVQILGEREVAYLTNESPDDCARRISRIITLEPPVLVVADDQTAPDTLLSMCERAQLPMFATPESAAFVIDVLRAYLSKHFADRTSMHGVFMDILGMGVMITGESGLGKSELGLELISRGHGLVADDAVDLYRINQTTIEGRCPELLQNLLEVRGIGLLDIKAIFGETAVRRKMRLKMIVHLVRRETLERDYERIPYEPLTQDVLGIPVRKVIIQVEAGRNIAVLVEAAVRNAILQLRGINTYQEFVERHRKAMEQDD
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: THPA_MYCS2
Sequence: MRLGTTAFAIASATALGLGLTACGAGDPAANSDTTRIGVTVYDMSSFITAGKEGMDAYAKDNNIELIWNSANLDVSTQASQVDSMINQGVDAIIVVPVQADSLAPQVASAKAKGIPLVPVNAALDSKDIAGNVQPDDVAAGAQEMQMMADRLGGKGNIVILQGPLGQSGELDRSKGIEQVLAKYPDIKVLAKDTANWKRDEAVNKMKNWISGFGPQIDGVVAQNDDMGLGALQALKESGRTGVPIVGIDGIEDGLNAVKSGDFIGTSLQNGTVELAAGLAVANRLAKGEPVNKEPVYIMPAITKDNVDVAIEHVVTERQQFLDGLTELINKNLETGDIAYEGIPGQKQP
What is the function of this protein?
Part of an ABC transporter complex involved in D-threitol import.  Binds D-threitol.  Functions in the transport for the degradation pathway of D-threitol, that allows M. smegmatis to grow on this compound as the sole carbon source.
What are the official names of this protein?
D-threitol-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 2 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: HTR2_HALVA
Sequence: EDEFGTLYAAFDNMRANLRTQISEAETAKQEAEAAKEQAQAAREDVESERNEMEALTGHLELKAQQYSDALDAAANGDLTARVKTDSMNDAMAEVGEDINTTLDALEDTIADMKAFATNVIQSSDRVNSNAERVDRASKQVSKSINEIFEGTTEQNEGLESAAAEMQNLSATAQQVASSAQQVADTSQSAAKVGEDGREAAQEAIAEMSAIEAETGETVEEINALDDELDEIGEIVGVITSIVEQTNMLALNASIEAAHADGDGEGFAVVADEIKGLAEETKEAAADIEGRIEAIQEQAGDTVETMESTSTRITEGVSTVEETVDALETIVEYTEEVDTGIQEIDRATEEQARTAQDVMGTIDDLTTISQQTATEADTVAGAAQDQSASIEEVSDSATELRQRADDLESLLDRFTVENSAGTGTDSTAAVGDD
What is the function of this protein?
Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor.  Responds to light changes through the variation of the level of methylation.  Also acts as a chemotransducer.
What are the official names of this protein?
Sensory rhodopsin II transducer, HTR-II, Methyl-accepting phototaxis protein II, MPP-II.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VG090_BPPF1
Sequence: MEESGIVGFTVTGAVEKVTDFRTAPFCSQAVFAQMLGLEDITEDVVRGWVETKTIPTAKIGRRRVVNLHRIRRDLDRGKSIFCQGDYDGD
What are the official names of this protein?
10.1 kDa protein, ORF 90.
Protein: FRDC_YERPG
Sequence: MTTKRKAYVRTMAPNWWQQLGFYRFYMLREGTSIPAVWFSVLLIYGVFSLKSGPAGWEGFVSFLQNPLVLFLNILTLFAALLHTKTWFELAPKAVNIIVKSEKMGPEPMIKALWVVTVVASAIILAVALL
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit C, Fumarate reductase 15 kDa hydrophobic protein, Quinol-fumarate reductase subunit C, QFR subunit C.
What is the protein family that this protein belongs to?
Belongs to the FrdC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UNG_EHV2
Sequence: MERWLQLHVWSKDQQDQDQEHLLDEKIPINRAWMDFLQMSPFLKRKLVTLLETVAKLRTSTVVYPGEERVFSWSWLCEPTQVKVIILGQDPYHGGQATGLAFSVSKTDPVPPSLRNIFLEVSACDSQFAVPLHGCLNNWARQGVLLLNTILTVEKGKPGSHSDLGWIWFTNYIISCLSNQLDHCVFMLWGSKAIEKASLINTNKHLVLKSQHPSPLAARSNRPSLWPKFLGCGHFKQANEYLELHGKCPVDWNLD
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines.  Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG, UNG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: HEM3_BORPD
Sequence: MSVPQRLVIATRASRLALWQAEHVRDRLRALYPACAVELLTLTTRGDQILDRTLSKVGGKGLFVKELETALLDGRADLAVHSLKDVPVDLQAPFELCAILERADPRDAFVSNQYTTLADLPAGAVVGTSSLRRESQIRQRYPHLSVKPLRGNLDTRLSKLDRGDYAAIVLAAAGLQRLGMGERIRSLLEPEDSLPAAGQGALGIEIRNDRNDLREWLAPLACSRTTACVVAERAVSRALGGSCQVPLAAYAELNGNSLALRALVASPDGTRVIRSQHAGPAEQAQAIGQAAAQELLSNGADAILAELQDPPAS
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: THIM_SHIB3
Sequence: MQVDLLSSAQSAHTLHLFHQHSPLVHCMTNDVVQTFTANTLLALGASPAMVIETEEASQFAAIASALLINVGTLTQPRAQAMRAAVEQAKSSQTPWTLDPVAVGALDYRRRFCLELLSHKPTAIRGNASEIMALAGVANGGRGVDTTDAAANAIPAAQTLARETGAIVVVTGEVDYVTDGHRIVGIHGGDPLMTKVVGTGCALSAVVAACCALPGDMLENVASACHWMKQAGERAVARSEGPGSFVPHFLDALWQLTQEVQA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RS10_HELP2
Sequence: MEKIRLKLKAYDHRVLDRSVVAIVEAVKRSGSEIRGPIPLPTKNKRYTVLRSPHVNKDSREQFEIRFYSRLIDIISATPETVDSLMKLDLAPEVDVEVTSMETK
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: BIOB_RICFE
Sequence: MKKWTFDEAKEIFSFSFMELVYQAQTIHRANFDPNKIQISSLLSIKTGSCPENCKFCPQSSHYKTYVKKEPLMQIEDVITAAKRAKAAGSTRFCMGAAWRGPRDEDLKLVCEMIKEVKKLGLETCVTLGLLKEHQAVTLKEAGLDFYNHNIDTSEEFYNKIITTRTFQDRLDTLRYVRASGMKVCCGGILGMGETNDDRINMILTLANLEEPAESVTINKLIKIPGTPLENVQDIDPFDFVRVIALARIMIPKSYIRLSAGREQMSDELQALCIMAGVYSIFYGEKILTSANPMPERDNDLFQKLGIIH
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: NUOC_LEGPH
Sequence: MTKNEYLIEKLQADLANHITELTSAYGEVTIECEVQNLLPVMIELRDREEFSFDQLIDLCGVDYLHYGDYDWETESATEHGFSRGVERQEAKAYAVNKPRFAVVYHLLSTKKNHRLRVKLFVEESHLIVPSVHHLWKSANWFEREAYDLYGILFDGHPDLRRLLTDYGFIGHPFRKDFPLSGEVEMRYDAKLQKVIYAPVDIVPRIVVPKVIRNDNRYIGNEGSKND
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HMP_CUPNH
Sequence: MLTQKTKDIVKATAPVLAEHGYDIIKCFYQRMFEAHPELKNVFNMAHQEQGQQQQALARAVYAYAENIEDPNSLMAVLKNIANKHASLGVKPEQYPIVGEHLLAAIKEVLGNAATDDIISAWAQAYGNLADVLMGMESELYERSAEQPGGWKGWRTFVIREKRPESDVITSFILEPADGGPVVNFEPGQYTSVAIDVPALGLQQIRQYSLSDMPNGRSYRISVKREGGGPQPPGYVSNLLHDHVNVGDQVKLAAPYGSFHIDVDAKTPIVLISGGVGLTPMVSMLKVALQAPPRQVVFVHGARNSAVHAMRDRLREAAKTYENLDLFVFYDQPLPEDVQGRDYDYPGLVDVKQIEKSILLPDADYYICGPIPFMRMQHDALKNLGIHEARIHYEVFGPDLFAE
What is the function of this protein?
In the presence of oxygen and NADH, FHP has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2), both in vitro and in vivo, and it has been suggested that FHP might act as an amplifier of superoxide stress.  Under anaerobic conditions, FHP also exhibits nitric oxide reductase and FAD reductase activities.  However, all these reactions are much lower than NOD activity.
What are the official names of this protein?
Flavohemoprotein, FHP, Flavohemoglobin, Hemoglobin-like protein, Nitric oxide dioxygenase, NO oxygenase, NOD.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMC_RABIT
Sequence: GPVAAVVRELRCVCLSTTAIHPKMIARLQVIAAGPQCSKVEVVASLKNGKEICLDPEAPLIKKAIQKILESGNKEN
What is the function of this protein?
Has chemotactic activity for neutrophils.
What are the official names of this protein?
Alveolar macrophage chemotactic factor, Neutrophil chemotactic protein, NPC.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: HSCB_SALPK
Sequence: MDYFTLFGLPARYQIDTQALSFRFQDLQRQYHPDKFANGTQAQQLAAVQQSATINQAWQTLRHPLTRAEYLLSLHGFDLASEQHTVRDTAFLMEQLTLREELDDIEQSKDDARLESFIKRVQKMFDARLQQMVEQLDNAAWDAAADTVRKLRFLDKLRSSAEQLEEKLLDF
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: RK22_WHEAT
Sequence: MTSFKLVKYIPRIKKKKSGLRKLARKVPTDRLLKFERVFKAQKRIPMSVFKAQRVLDEIRWRYYEETVMILNLMPYRASYPILKLVYSAAANATHYRDFDKANLFITKAEVSRSTIMKKFRPRARGRSFPIKKSMCHITIVLNIVKKS
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LBD21_ARATH
Sequence: MRGHEPRSSSSCAACKLLKRRCTPTCIFAPYFRSSDLITFAKVHKVFGASNVSKLLGEVPEEQRQETVNSLAYEAEVRLKDPVYGCIGAIASLQKKMLELQHDLAVARTRLLAHSGVNNSQVSPLDDSPELAAFLDLVPYSDLMLLDGSTNLDAYLYDLGQPPFV
What are the official names of this protein?
LOB domain-containing protein 21, ASYMMETRIC LEAVES 2-like protein 12, AS2-like protein 12.
What is the protein family that this protein belongs to?
Belongs to the LOB domain-containing protein family.
Protein: NUOI_NOVAD
Sequence: MTVGQLIKSFTLWEFVKAHWLTLKYFFKPKATINYPFEKNPLSPRFRGEHALRRYPNGEERCIACKLCEAVCPAQAITIEAEPREDGSRRTTRYDIDMTKCIFCGFCQEACPVDAIVEGPNFEYATETREELLYDKAKLLSNGDKWERAIAANLEADAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: C79F1_ARATH
Sequence: MMSFTTSLPYPFHILLVFILSMASITLLGRILSRPTKTKDRSCQLPPGPPGWPILGNLPELFMTRPRSKYFRLAMKELKTDIACFNFAGIRAITINSDEIAREAFRERDADLADRPQLFIMETIGDNYKSMGISPYGEQFMKMKRVITTEIMSVKTLKMLEAARTIEADNLIAYVHSMYQRSETVDVRELSRVYGYAVTMRMLFGRRHVTKENVFSDDGRLGNAEKHHLEVIFNTLNCLPSFSPADYVERWLRGWNVDGQEKRVTENCNIVRSYNNPIIDERVQLWREEGGKAAVEDWLDTFITLKDQNGKYLVTPDEIKAQCVEFCIAAIDNPANNMEWTLGEMLKNPEILRKALKELDEVVGRDRLVQESDIPNLNYLKACCRETFRIHPSAHYVPSHLARQDTTLGGYFIPKGSHIHVCRPGLGRNPKIWKDPLVYKPERHLQGDGITKEVTLVETEMRFVSFSTGRRGCIGVKVGTIMMVMLLARFLQGFNWKLHQDFGPLSLEEDDASLLMAKPLHLSVEPRLAPNLYPKFRP
What is the function of this protein?
Catalyzes the conversion of the short chain elongated methionines di-, tri-, and tetrahomomethionine to their respective aldoximes 5-methylthiopentanaldoxime, 6-methylthiohexanaldoxime, and 7-methylheptanaldoxime.
What are the official names of this protein?
Dihomomethionine N-hydroxylase, Cytochrome P450 79F1, Protein BUSHY 1, Protein SUPERSHOOT 1, Trihomomethionine N-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: UREE_HELPH
Sequence: MIIERLVGNLRDLNPLDFNVDHVDLEWFETRKKIARFKTRQGKDIAIRLKDAPKLGLSQGDILFKEEKEIIAVNILDSEVIHIQAKSVAEVAKICYEIGNRHAALYYGESQFEFKTPFEKPTLALLEKLGVQNRVLSSKLDSKERLTVSMPHSEPNFKVSLASDFKVVMK
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_CLOBL
Sequence: MKVLNNLLYTGDHEWVRVEDNKAYIGISDCAQRMLSDIVFVELPEVDDEIAKGETFATIESVKAASDSYMPVSGTIVEINEELEDNPAALNEDPYGSWIAAIEMSDKNELEELIKPEVYEKICEELDKEA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: DIL1_SCHPO
Sequence: MDELLEKLLNDLKKKEPKACSIICIGEDLDIIQCMNEHGCFSGGSYSELSNDCETVNFRGIAYKCFFTKDQVKVNFWQISHLTGGLFNFLVSQALNEHGLDLLWIIMVVAQTLSALVSFPEKLLNILRNMKTILINTEETVRNRFEESQNKKLVALLDKNSTTLDISSGILLNFTVVLKQLKHALGLHTSVDNSQEFILQFLRTTLLSVPTSSIVSISADPTSWNNLNVLMKYNFMFQKFKPRDFHAQTIQSETMFIPPCWDTISKIQSVNHEFNIALFKQTAKNFYDTLDISLLLGLFDKSISMLNCHSSKISDGDIPYKSHQVFLQELQNKYSEIKTYSSNKLNKSSIKSSLWKDLIQ
What is the function of this protein?
Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity).  Promotes oscillatory nuclear movement and efficient pairing of homologous centromeres during meiotic prophase.
What are the official names of this protein?
Dynein intermediate light chain dil1.
What is the protein family that this protein belongs to?
Belongs to the dynein light intermediate chain DYN3 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Localized to the leading edge of the horsetail nucleus, where the spindle pole body (SPB) is expected, and to the leading microtubules. In cycling cells, forms foci which distributed asymmetrically during cell division.
Protein: GLPK_SALPA
Sequence: MTEKKYIVALDQGTTSSRAVVMDHDANIVSVSQREFEQIYPKPGWVEHDPMEIWASQSSTLVEVLAKADISSDQIAAIGITNQRETAIVWERETGKPIYNAIVWQCRRTADICEQLKRDGLEDYIRDNTGLVVDPYFSGTKVKWILDHVEGSRERAKRGELLFGTVDTWLIWKMTQGRVHVTDYTNASRTMLFNIHDLDWDDKMLDVLDIPRAMLPQVRKSSEVYGQTNIGGKGGTRIPIAGIAGDQQAALFGQLCVKEGMAKNTYGTGCFMLMNTGEKAVKSENGLLTTIACGPSGEVNYALEGAVFMAGASIQWLRDEMKLISDAFDSEYFATKVKDTNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNSNHIIRATLESIAYQTRDVLEAMQADSGIRLHALRVDGGAVANNFLMQFQSDILGTRVERPEVREVTALGAAYLAGLAVGYWQNLDELQEKAVIEREFRPGIETTERNYRYSGWKKAVKRAMAWEEHDK
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: 3BHS1_MESAU
Sequence: MPGWSCLVTGAGGFLGQRIIRMLVQEKELQEVRALDKVFRPETREEFCKLQTKTKVTVLEGDILDAQCLRRACQGISVVIHTAAAIDVFGAIPRQTIIDINLKGTLNLLEACVQASVPAFIYTSSIDVAGPNSYKEIVLNGHEEQQHESTWSDPYPYSKKMAEKAVLAANGSSLKNGGTLHTCALRPMYIYGEKSPLISVTIIRAVKNSGILDVTGKFSTVNPVYVNNAAWAHILAARGLQDPRKSPNIQGQFYYISDDTPHQSYDDLNYVLSKDWGLRPDSSWRPPVALLYWLGFLLELVSFLLRPVYNYQPPFNRHLVTLSNTVFTFSYKKAQRDLGYEPLVGWEEARENTSEWIGSLVEQHKGTLNTKAQ
What is the function of this protein?
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis.  Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone.  Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms.  Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR.  Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone.  Expected to use NAD(+) as preferred electron donor for the 3-beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity.
What are the official names of this protein?
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-HSD I, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, Delta-5-3-ketosteroid isomerase, Dihydrotestosterone oxidoreductase, Steroid Delta-isomerase.
What is the protein family that this protein belongs to?
Belongs to the 3-beta-HSD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Protein: KPYK1_ECOLI
Sequence: MKKTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAAILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNTVLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLEFNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVPQLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHVL
What is the function of this protein?
Catalyzes the formation of pyruvate in the last step of glycolysis, it is irreversible under physiological conditions.  The reaction is critical for the control of metabolic flux in the second part of glycolysis.
What are the official names of this protein?
Pyruvate kinase I, PK-1.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
Protein: Y3708_SHESR
Sequence: MTKKIELAQIQVLFLGIWRFLLHLRQRLVEDQINIRAGHLAYVTLLSLVPMVAVTMSMLSAFPVFKGIRGQIEAFVYENFLPAAGDTVQVYINEFVGNASKGTAVGIAALVVVAIMLISAIDKSLNNIWRTKEKRSVVVAFSMYWMVITLGPVLVGASLVATSYVVSLKLFEGDALSGVMPLFIERLPMLFSVAAFLLLYMVVPNQKVKFWHALLGAVVAALLFELGKKGFALYVTKFPSYEAIYGALATIPILFVWVYLSWMIVLLGAEITAAMPEYLDYESSSDINETNLDGQPLAAQDTPAAQPETTSAQSSQVLETTDELAATAPQSSTLDKP
What are the official names of this protein?
UPF0761 membrane protein Shewmr7_3708.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CH60_MYCGO
Sequence: PYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLRNVAAGANPLGLKRGIEKAVEKITQTLLSSAKDVETKEQIAATAGISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGL
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, 65 kDa heat shock protein, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA_VIBA3
Sequence: MVTKTLSVLFVASEVEGLIKSGGLADVAKALPKALQTLEQDVRVTIPAYRNIPNIDSAEVILSTELDHWPHTAYQVKKLSVEGVQIFAIECAKYFDRPEMYAENNQAYADNGERFSFFSTACLDMLPKLAFQPDIIHANDWHTGFVPFLLKSRYQQHDFFENTRSVISIHNAVFKGVFAYDELQCLSEMHSYNVPEASVSDTHVTMLKAGVMCADKINAVSPTYAEELKTELGSHGMAAEFQHRSADLFGILNGCDYGAWNPETDAFLPRKFKATKHSMTRGKSACKQKLQQDVGLPVTDCAVYGMVCRLTNQKGVHYLLPIIEQFLKNELQIVIVGTGDPVLASQLKELSALHSDKFSFVEAYNNELAHLVEAGSDFFLMPSEFEPCGLNQIYSMAYGTLPIVRSVGGLKDSVNDYDQEPEIATGFAFEEPTPQALLAVLHRSLLLYAQNPSEIKRVQLYAMQQDFSWEDAAEEYLAMYHSAF
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: CBRA_ECOL6
Sequence: MEHFDVAIIGLGPAGSALARKLAGKMQVIALDKKHQHGTEGFSKPCGGLLAPDAQRSFIRDGLTLPVDVIANPQIFSVKTVDVAASLTRNYQRSYININRHAFDLWMKSLIPASVEVYHDSLCRKIWREDDKWHVIFRADGWEQHITARYLVGADGANSMVRRHLYPDHQIRKYVAIQQWFAEKHPVPFYSCIFDNAITDCYSWSISKDGYFIFGGAYPMKDGQTRFTTLKEKMSAFQFQFGKAVKSEKCTVLFPSRWQDFVCGKDNAFLIGEAAGFISASSLEGISYALDSAEILRSVLLKQPEKLNTAYRRATRKLRLKLFGKIVKSRCLTAPALRKWIMRSGVAHIPQLKDYPTRFTSPTSRM
What are the official names of this protein?
Protein CbrA.
What is the protein family that this protein belongs to?
Belongs to the CbrA family.
Protein: HIS2_CLAM3
Sequence: MKTFDDLFGELTRIAAERPEGSGTVRELDGGVHAIGKKVVEEAAEVWMAAEHESDDRAAEEISQLLYHVQVMMIARGLTLEDVGRHL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.