PharMolix/UniProtQA huggingface dataset:
Protein: MTND_FUSV7
Sequence: MRAYFYDGLPGDQRLPHDSGKPVNVDDLLAIGVYYYHLPELESVDNLARDRGYKNRDEITVSPKTMGDVYESKVKMFFAEHLHEDEEIRYIRGGRGYFDVRSKDDDWVRVLLEKDDLLILPAGIYHRFTTDETNYVHAMRLFKEDPKWTALNRGPEVDNNGHRQEYVKTFLAEPAQ
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RUVB_TRIEI
Sequence: MAIISSKKQSPQPERPDDDIFLASENQVSYKYKTKKSKSQAQRSEVEALLEPEASAAEKSDNQNEEKIRPQRLDEYIGQKDLKEVLNIAISAAKSRKESLDHLLLYGPPGLGKTTMSLILAAEMEVNCKITTAPAIEKPRDIVGLLVGLQKGDILFIDEIHRLSKMTEEILYPAMEDFRLDITVGQGKSSKTRSIPLKPFTLVGATTKVGSLTSPLRDRFGIIQRLRFYEVDELSLIIIRAAKVLNTDITEDGAEEVARRSRGTPRIANRLLRRVRDYSEVKKLTPINAEIAGEALELFNVDPLGLDWTDRNLLRTMIENYNGGPAGLETMAAATGEDAQTIEEVYEPYLMQIGFMQRTPRGRVVTAAGWRHLGFSPPDEQLSLKL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SEPF_BACAN
Sequence: MSWSKVKYFFFDTPEEKEAAQYSYEKEQTDMKKQQDPPEQQDVTFPKAQPKQNVVSIETAKQSSKVVLLEPRTYSEAQGIADHLKGRRAVVINLQRMSTDQAVRIVDFLSGTVYAIGGDIQKIGPKTFMCTPENVDIVGAISELFGEEDDTNIKRW
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: GSPK_PECCC
Sequence: MRSRQRGAALLVVLLILALMVTIAAVITERTGKAFLRTESHLSRQQAKWYALGAETLSGQILQRDARNMPGRTFAGQNWSQPGLRFPVDGGEITGQISDARTCFNVNAINQGVDNESTLVKTPYPAQVFRLLLKNLGEETDRAEKITAAVRDWIDADNYPSANGAEDDVYAALPVPYRTANQRMSEISELRSVYGIDSDLYRRLLPYVCALPVDAMSININTLTEFDAPLLSAVFLNEMTMSQAKALVQQRPRMGWASLEVLQQTGLLPPNSKNTAQRVLAVKSEWFFVKLQVRVGDSDFHQRSLLHLSGQKVQVVQRQYGGYRTVNP
What is the function of this protein?
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Plays a role in pseudopilus assembly and seems to control its length.  Interacts with the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.
What are the official names of this protein?
Type II secretion system protein K, T2SS protein K, General secretion pathway protein K, Pectic enzymes secretion protein OutK.
What is the protein family that this protein belongs to?
Belongs to the GSP K family.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: RS13_ECO57
Sequence: MARIAGINIPDHKHAVIALTSIYGVGKTRSKAILAAAGIAEDVKISELSEGQIDTLRDEVAKFVVEGDLRREISMSIKRLMDLGCYRGLRHRRGLPVRGQRTKTNARTRKGPRKPIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the E. coli 70S ribosome in the initiation state it has been modeled to contact the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; bridge B1a is broken in the model with bound EF-G, while the protein-protein contacts between S13 and L5 in B1b change.  Contacts the tRNAs in the A and P sites (By similarity).
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MCM5_BOVIN
Sequence: MSGFDDPGIFYSDSFGGDNAADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEELADYLYKQPAEHLQLLEEAAKEVADEVTRPRPAGDEVLQDIQVMLKSDASPSSIRSLKSDTMSHLVKIPGIVIAASGVRAKATRISIQCRSCHSTLTNIAMRPGLDGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTSNRGRDRVGVGIRSAYIRVLGIQVDTDGSGRTFAGAMTPQEEEEFRRLAALPNIYELISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQAQAVEGEIDLAKLKKFIAYCRAKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGVEGFTSQEDQELLSRIEKQLKRRFAIGSQVSEHSIIQDFTKQKYPEHAIHKVLQLMLRRGEIQHRMQRKVLYRLK
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
What are the official names of this protein?
DNA replication licensing factor MCM5.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm, cytosol. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: PUR2_PYRFU
Sequence: MVKVLLVGGGGREHAIGEALVKGGAELYVVSKHKNPGLARIAKDYGLARETDVEKVVEFAEKWKVDFAFIGPEAPLEAGVVNALEERGIPAVGPTKEAARLETNKAWAREFMERNKIPGRKLFRVFDDPKEMKEWIDEFGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIRKDGKVLIEERTDGVEFTFQVFSDGKKVVPMPLAQDYPHAYEGDVGPITGGMGSYSCSNHLLPFITKSDWEKALETLQKTVEAMYKEGYPYKGILYGQFMLSKDGPVIIEYNARFGDPEAINVLSILEDNLVEISERIIDGNLRDVKFSNMATVVKYIAPQGYPENPIKGVRIEVNEDKIREEGARLIFASIDENYTLLGSRALAVVGVSENLEEAEKIAQSAIRHVKGPIFYRKDVGTRESIEKRIKIMKSLRGDFDVNSC
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: RL34_BURM9
Sequence: MKRTYQPSVTRRKRTHGFRVRMKTAGGRKVINARRAKGRKRLAI
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RL15_DESVV
Sequence: MRLHDLYPFPEERKTRKRVGRGSGSGLGCTSGKGNKGQNARAGGGVRPGFEGGQMPLQRRLPKRGFKNMFAVKYEVINLARLLAAFEGKAEITLDDIYDRGLCSLGSAVKILGEGDVTTAIKVEAHKFSASAVEKIRNAGGEAKALEG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: Y6489_DICDI
Sequence: MEFIINKINNIKNNNDNNNNINNNSNNNNNNNNNSNNNKFKFKYEFEFGYCYDVNLYEWRFIQDYETVPLKLNGILSNDEYNSILNIIGDVYDKTDKYPHVTYLLSIIMMVLLCMLPSVMAIHSNLNSYIQFVLFDDIFILITFILIPFLFFLKKKVIIENNYVIKGLKNRSIKLNIEYYKFKLLYFFFLLLWVPQGFLQSLIYKKRVLNEDFFNLKISLFILLGIDLIFILFAIWNFLLFTKLNRFLIKDRRDENILITLNSNIKKFLSPMEFYLTCNNTLNFFLNNNDNHFFPIDLDDPNV
What are the official names of this protein?
Putative uncharacterized transmembrane protein DDB_G0285385.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RNT_KLEP7
Sequence: MSENAQLNGLCDRFRGFYPVVIDVETAGFNAKTDALLEIAAITLKMDEHGWLMPDETLHFHVEPFEGANLQPEALAFNGINPHDPQRGAVSEYDALHAIFKMVRKGMKESDCSRAIMVAHNATFDHSFTMTAAERAGLKRNPFHPFVTFDTAALSGLALGQTVLSKACIAAGMPFDGAQAHSALYDTEQTAQLFCEIVNRWKRLGGWPLPVATPE
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.
Protein: SYL_SALTY
Sequence: MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVVARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKTLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLRDLDKLDHWPDTVKTMQRNWIGRSEGVEITFDVKGYDNTLTVYTTRPDTFMGATYLAVAAGHPLAQKAAANNAELAAFIDECRNTKVAEAEMATMEKKGVDTGYKAIHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLTIKPVILAADGSEPDLSEQALTEKGVLFNSGEFDGLAFEAAFNAIADKLAEKGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVLPTPEDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTCPQYQEGMLDSKAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVTSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFIKRVWKLVYEHTAKGPVAALNVDALSEDQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPQEGEQDRALLQEALQAVVRMLNPFTPHVCFTLWQELGGEGDIDNAPWPVADEQAMVENTTLVVVQVNGKVRGKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_XYLF2
Sequence: MVSKFDTQHLLNSNTALVAGVDEAGRGPLAGPVVVAAVVFDPSQPHINGLNDSKQLSPACRERLYAHIVERALAYKVVMIDSTQIDTLNIYQATMLGMRLAVEGVAHVAKSARIDGNRLPKNLPCPAEALVGGDARDPTIMAASILAKVTRDRHMVELHLQYPHYGFDKHKGYGTPAHLAALAEHGPCLEHRQSFAPVRRMLTPKAIHARQSAHQHNENSPTKAAFNMLIERDD
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_PSEPF
Sequence: MKTLWQHCHVATMAQGVYSIIEDAAIVTSGALIEWIGPRSQLPSGEYPAVNDLQGAWVTPGLIDCHTHTVFGGNRSGEFEKRLQGVSYAEIAAAGGGIASTVRATREASEDELFASAAKRLKSLMRDGVTTVEMKSGYGLDLASERKILRVIRRLAAELPISVRSTCLAAHALPPEYQDRADDYIDHICAEMLPALAAEGLVDAVDAFCEYLAFSPEQVERVFIAAQKLGLPVKLHAEQLSSLHGSSLAARYHALSADHLEFMDEADAIAMAESDTVAVLLPGAFYFLRETRLPPMEALRKHKVKIAIASDLNPGTSPALSLRLMLNMACTCFRMTPEEALAGATIHAAQALGMAETHGSLEVGKVADFVAWQIDRPADLAYWLGGELDKRVVRHGVESSL
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAIN_DROME
Sequence: MDFNNCGFIDPQAQLAGALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTPGCRDFIEACIDHGSQVNYINKKLDKAAISYAADSRDPGNLAALLKYRPGNKVQVDRKYGQLTPLNSLAKNLTDENAPDVYSCMQLLLDYGASPNIVDQGEFTPLHHVLRKSKVKAGKKELIQLFLDHPELDIDSYRNGEVRRLLQAQFPELKLPEERHTGPEIDIQTLQRTLRDGDETLFEQQFAEYLQNLKGGADNQLNAHQEEYFGLLQESIKRGRQRAFDVILSTGMDINSRPGRANEANLVETAVIYGNWQALERLLKEPNLRLTPDSKLLNAVIGRLDEPPYDGSSHQRCFELLINSDRVDINEADSGRLVPLFFAVKYRNTSAMQKLLKNGAYIGSKSAFGTLPIKDMPPEVLEEHFDSCITTNGERPGDQNFEIIIDYKNLMRQERDSGLNQLQDEMAPIAFIAESKEMRHLLQHPLISSFLFLKWHRLSVIFYLNFLIYSLFTASIITYTLLKFHESDQRALTAFFGLLSWLGISYLILRECIQWIMSPVRYFWSITNIMEVALITLSIFTCMESSFDKETQRVLAVFTILLVSMEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFYILFGKSVEEDQSKSATPCPPLGKKEGKDEEQGFNTFTKPIEAVIKTIVMLTGEFDAGSIQFTSIYTYLIFLLFVIFMTIVLFNLLNGLAVSDTQVIKAQAELNGAICRTNVLSRYEQVLTGHGRAGFLLGNHLFRSICQRLMNIYPNYLSLRQISVLPNDGNKVLIPMSDPFEMRTLKKASFQQLPLSAAVPQKKLLDPPLRLLPCCCSLLTGKCSQMSGRVVKRALEVIDQKNAAEQRRKQEQINDSRLKLIEYKLEQLIQLVQDRK
What is the function of this protein?
Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature.  Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.
What are the official names of this protein?
Transient receptor potential cation channel protein painless.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ISU1_SCHPO
Sequence: MSVFRRSVQCVGVLPSILAQRSSLLARPANLQFLKTNSSKFVPQVTANVSRRMYHKNVLDHYNNPRNVGTLPKGDPDVGIGLVGAPACGDVMRLAIRVNKDGVIEDVKFKTFGCGSAIASSSYVTTMVKGMTLEEASKIKNTQIAKELCLPPVKLHCSMLAEDAIKSAVKHYRSKQLTPVGTTAGAIESATA
What is the function of this protein?
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.  First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein isu1.  In a second step, the cluster is released from isu1, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins.  Cluster assembly on isu1 depends on the function of the cysteine desulfurase complex nfs1-isd11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH.
What are the official names of this protein?
Iron sulfur cluster assembly protein 1, mitochondrial, Iron sulfur cluster scaffold protein 1.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion matrix.
Protein: Y1416_STAES
Sequence: MNVFQMRDKLKARLKHLDVEFKFDREEETLRIVRIDNHKGVTIKLNAIVAKYEEQKEKIIDEICYYVEEAIAQMGDEVINNVEDIQIMPVIRATSFDKETKEGHAFVLTEHTAETNIYYALDLGKSYRLIDENMLQTLNLTAQQVKEMSLFNVRKLECRYSTDEVKGNIFYFINTNDGYDASRILNTSFLNHIQHQCEGEMLVGVPHQDVLILADIRNKTGYDVMAHLTMEFFTKGLVPITSLSFGYDNGHLEPIFILGKNNKQKRDPNVIQRLEANRKKFKKD
What are the official names of this protein?
UPF0354 protein SE_1416.
What is the protein family that this protein belongs to?
Belongs to the UPF0354 family.
Protein: FMAR_DROME
Sequence: MSGTAVARLLLRLELPSPGVMPPPPTDYDYGGPISDDEFLASAMATEGPTVRYDLFPQNNSQPTLQIVLNHTEVQTDLQYPHYEDLGLDPDPNWTRICEDVYNPLLENNRIEFWVCGVLINIVGVLGILGNIISMIILSRPQMRSSINYLLTGLARCDTVLIITSILLFGIPSIYPYTGHFFGYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKDVILHCVRPSRLRRSETYINIYIHWCYLIVNYIIPFLTLAILNCLIYRQVKRANRERQRLSRSEKREIGLATMLLCVVIVFFMLNFLPLVLNISEAFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRLSRDQPDLIHYESSISNNGDGTLNHRSSGRFSRHGTQRSTTTTYLVATGGPGGGGCGGGGGNNSLNNVRLTQVSGSPGLVKIKRNRAPSPGPVVYFPAREMQRSASTTNSTTNNNTSIGYDWTLPDSKKLGHVSSGF
What is the function of this protein?
A receptor for the FMRFamide peptides (PubMed:12218185, PubMed:12438685).  Reacts with high affinity to FMRFamide and intrinsic FMRFamide-related peptides (PubMed:12218185, PubMed:12438685).  By stimulating intracellular calcium signaling through the inositol 1,4,5-trisphosphate receptor, Itpr, in dopaminergic neurons, may be involved in the maintenance of neuronal excitability and in the regulation of flight bout duration (PubMed:30110323).
What are the official names of this protein?
FMRFamide receptor, DFR, DrmFMRFa-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PARD3_HUMAN
Sequence: MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDKTGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERIRMKQEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNSKPSPVDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPNARPATQSGRHSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAKENPRYSSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS
What is the function of this protein?
Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424).  Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688).  Targets the phosphatase PTEN to cell junctions (By similarity).  Involved in Schwann cell peripheral myelination (By similarity).  Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity).  The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474).  Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688).
What are the official names of this protein?
Partitioning defective 3 homolog, PAR-3, PARD-3, Atypical PKC isotype-specific-interacting protein, ASIP, CTCL tumor antigen se2-5, PAR3-alpha.
What is the protein family that this protein belongs to?
Belongs to the PAR3 family.
What are the subcellular locations of this protein?
Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cell junction, adherens junction. Cell membrane. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Colocalized with SIRT2 in internode region of myelin sheath (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.
Protein: TBO1_TIBOB
Sequence: MKKTFCFILILVCIVLKSVNAEEEDNFEESSLEMETARCASKNERCGNALYGTKGPGCCNGKCICRTVPRKGVNSCRCM
What is the function of this protein?
Insect-specific toxin that probably acts as an inhibitor of presynaptic insect calcium channels, presumably Cav2 subtype.  In vivo, induces immediate paralysis on insects, followed by death when high doses are injected.
What are the official names of this protein?
Omega-phylotoxin-To1a, Omega-PHTX-To1a, Omega-Tbo-IT1.
What are the subcellular locations of this protein?
Secreted.
Protein: RS17_BRUO2
Sequence: MPKRVLQGVVVSDKNDKTVVVKVERRYSHPLLQKTVRQSKKYKAHDENNQFKVGDFVSIQESAPISKDKRWVVLTSEAAG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: HIS8_SHIFL
Sequence: MSTVTITDLARENVRNLTPYQSARRLGGNGDVWLNANEYPTAVEFKLTQQTLNRYPECQPKAVIENYAQYAGVKPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPTLENWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRGKAIVVADEAYIEFCPQASLAGWLAEYPHLAILRTLSKAFALAGLRCGFTLANEEVINLLMKVIPPYPLSTPVADIAAQALSPQGIVAMSERVAQIITEREYLIAALKEIPCVEQVFDSETNYILARFKASSAVFKSLWDQGIILRDQNKQPSLSGCLRITVGTREESQRVIDALRAEQV
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: KAD_SHEAM
Sequence: MRIILLGAPGAGKGTQAQFIMEHYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERIAQDDCANGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVNRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLVIRPDDEESTVRKRLGIYHEQTKPLVDYYGKVAAEGNTKYTKFDGTQSVAEVSKLIQAALS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.