PharMolix/UniProtQA huggingface dataset:
Protein: RNF4_RAT
Sequence: MSTRNPQRKRRGGAVNSRQTQKRTRETTSTPEISLEAEPIELVETVGDEIVDLTCESLEPVVVDLTHNDSVVIVEERRRPRRNGRRLRQDHADSCVVSSDDEELSKDKDVYVTTHTPRSTKDEGTTGLRPSGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNANTCPTCRKKINHKRYHPIYI
What is the function of this protein?
E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:14987998, PubMed:18408734, PubMed:15707587).  Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:15707587, PubMed:20943951).  Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (By similarity).  Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (By similarity).  Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:11319220, PubMed:9710597).  Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF4, RING finger protein 4, Small nuclear ring finger protein, Protein SNURF.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.
Protein: HFLC_BUCAP
Sequence: MNKIVICILSFFLLIFSSSFFIVKEGERGIILQFGKVLRNNKQKTLVYTPGLHFKIPFFENVKILDSRIHTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDFFQAEVLLKRKFSDRLRSEIGRLNVKEIVTDSRGRLTTDVLYSLNKGTINLDSTSLINVNSMNALGIEVVDVRIKQINLPLEVSDAIYNRMRAERESVARSQRSQGQEKAEKLRATADYRVSLILAEAQKKALMIKGQGEAEVAKLFLENFGQESSFYFFIRSLHAYENSFKNSNNIMLINSDNEFFKYMNTEIKN
What is the function of this protein?
HflC and HflK could regulate a protease.
What are the official names of this protein?
Protein HflC.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family. HflC subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: KDSB_SHEPA
Sequence: MNVTLLIPARYGSSRFPGKPLAHINGKPMIQHVYERASLAKGLKDIYVATDDVRIKNAVESFGGKVVMTGENAASGTDRIDEAISILGLADDDLVINLQGDQPLIDPIVIEQLVSVCERHAGEFDMATLGVEIKDEAQLNDPNHVKVVFDNNHNALYFSRARIPFGRDTSDYPVYKHIGIYAYTRKFIQTFAKLPLGRLEELEKLEQLRALEYGYKIKVAISAFDFPEVDTPEDIRICEARLTVD
What is the function of this protein?
Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus.
What are the official names of this protein?
8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase, CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1A12_ORYSJ
Sequence: MAYQGIDLLSTKAAGDDHGENSSYFDGWKAYDTNPFDLRHNRGGVIQMGLAENQLSLDLIEEWSKNHPEASICTPEGVSQFKRIANFQDYHGLPEFRKAMAQFMGQVRGGKATFDPDRVVMSGGATGAQETLAFCLANPGEAFLVPTPYYPAFDRDCCWRSGIKLLPIECHSFNDFRLTKEALVSAYDGARRQGISVKGILITNPSNPLGTITDRDTLAMLATFATEHRVHLVCDEIYAGSVFATPEYVSIAEVIERDVPWCNRDLIHVVYSLSKDFGLPGFRVGIIYSYNDAVVAAARRMSSFGLVSSQTQYFLARMLSDEEFIGRFLQESKCRLVARHERFTSGLREVGIGCLRGNAGLFSWMDLRRMLREKTAEAELELWRVIVHQVKLNVSPGTSFHCREPGWFRVCHANMDDETMEVALGRIHDFVRQHQQRRVKAERWAANRQLRLSLPHHHHLSPAHLSSPLALLSPQSPMVRATS
What is the function of this protein?
Catalyzes the formation of 1-aminocyclopropane-1-carboxylate, a direct precursor of ethylene in higher plants (Probable).  Involved in defense response by producing ethylene after pathogen infection (PubMed:17012402, PubMed:23031077).  Involved in several phospate deficiency-induced adaptive responses, such as lateral root elongation (PubMed:30810167).
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate synthase 2, ACC synthase 2, OsACS2.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: COBD_MYCTO
Sequence: MFASTWQTRAVGVLIGCLLDVVFGDPKRGHPVALFGRAAAKLEQITYRDGRVAGAVHVGLLVGAVGLLGAALQRLPGRCWPVAATATATWAALGGTSLARTGRQISDLLERDDVEAARRLLPSLCGRDPAQLGGPGLTRAALESVAENTADAQVVPLLWAASSGVPAVLGYRAINTLDSMIGYRSPRYLRFGWAAARLDDWANYVGARATAVLVVICAPVVGGSPRGAVRAWRRDAARHPSPNAGVVEAAFAGALDVRLGGPTRYHHELQIRPTLGDGRSPKVADLRRAVVLSRVVQAGAAVLAVMLVYRRRP
What is the function of this protein?
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
What are the official names of this protein?
Cobalamin biosynthesis protein CobD.
What is the protein family that this protein belongs to?
Belongs to the CobD/CbiB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: H2A_OLILU
Sequence: AGAPVYLAAXXXYLTAEILXLAGNAARDNKKSRIIPRHVQLAVXXXXXLNKLLGNVTIAQGGVLPNI
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CRK_XENLA
Sequence: MAGNFDSEDRASWYWGKQNRQEAVNLLQGQRHGVFLVRDSTTIPGDYVLSVSENSKVSHYIINSVTNNRQSSTAGMVQSRFRIGDQEFDSLPTLLEFYKIHYLDTTTLIEPVSKSKQSGVIQRQEEVEYLRALFDFIGNDDEDLPFKKGDILRIREKPEEQWWNAEDSDGRRGMIPVPYVEKYRPPSSPGSALIGGNQENSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIFARVIQKRVPNAYDKTALALEVGDLVKVTKINVSGQWEGECNGKYGHFPFTHVRLLEQNPEEDFS
What is the function of this protein?
Required for apoptosis in Xenopus egg extracts (PubMed:9029144).  Involved in cell branching and adhesion (By similarity).  May mediate attachment-induced mapk8 activation, membrane ruffling and cell motility in a Rac-dependent manner.  May regulate the efna5-epha3 signaling (By similarity).
What are the official names of this protein?
Adapter molecule crk, CRK2, SH2/SH3 adaptor crk.
What is the protein family that this protein belongs to?
Belongs to the CRK family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion.
Protein: RL3_PELUB
Sequence: MSEIALIGKKIGMTREFYKTGRLVPVTVIKMEKARVIQVIEEEKRGYKAVQLGFGKIKASKLTKAMKGLYAKKNTEAKKKLKEFRVKDTELYKEGNEFGLEIFNEVKFVDTTSKTIGKGFAGAMKRHNFGGLRATHGVSVSHRSHGSTGQRQDPGKVFKGKKMAGHMGDRVRTMQNLEIIKTDIENELLYLKGSIPGSKNTEILVKKSVKVINKMTINEKIAAAEEAKKTPDKKKK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: GATB_CHLTB
Sequence: MGIAHTEWESVIGLEVHVELNTESKLFSPARNHFGDEPNTNISPVCTGMPGSLPVLNKDAVRKAVLFGCAVEGDVALFSRFDRKSYFYPDSPRNFQITQYEHPIVRGGCIRAVVEGEEKTFELAQTHLEDDAGMLKHFGDFAGVDYNRAGVPLIEIVSKPCMFSAEDAVAYANALVSILGYIGISDCNMEEGSIRFDVNISVRPRGSRELRNKVEIKNMNSFTFMAQALEAEKRRQIEEYLSHPNEDPKKVVPAATYRWDPEKKKTVLMRLKERAEDYMYFVEPDLPVLQITETYIDEVRQTLPELPHSKYMRYITDFDIAEDLAMILVGDRHTAHFFETATMSCKNYRALSNWITVEFAGRCKAKGKTLPFTGILPEWVAQLVNFIDRGVITGKIAKEIADRMVSSFGESPEDILRRHPSLLPMTDDHALRAIVKEVVAQNTASVADYKNGKAKALGFLVGQIMKRTEGKAPPKRVNELLLAAMRDM
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: CDK20_HUMAN
Sequence: MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG
What is the function of this protein?
Required for high-level Shh responses in the developing neural tube.  Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity).  Involved in cell growth.  Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.
What are the official names of this protein?
Cyclin-dependent kinase 20, CDK-activating kinase p42, CAK-kinase p42, Cell cycle-related kinase, Cell division protein kinase 20, Cyclin-dependent protein kinase H, Cyclin-kinase-activating kinase p42.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, cilium.
Protein: PYRG_ECO8A
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLSEWEQVIFEEANPVSEVTIGMVGKYIELPDAYKSVIEALKHGGLKNRVSVNIKLIDSQDVETRGVEILKGLDAILVPGGFGYRGVEGMITTARFARENNIPYLGICLGMQVALIDYARHVANMENANSTEFVPDCKYPVVALITEWRDENGNVEVRSEKSDLGGTMRLGAQQCQLVDDSLVRQLYNAPTIVERHRHRYEVNNMLLKQIEDAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAASEFQKRQAK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: GRPE_PSE14
Sequence: MADEQNLDAQAQDQAAEAGAGEELTTRVQVLEEQLAAAQDQSLRVAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPIIDSLERGLDLSNPDDESIRPMREGIELTLKMFQDTLKRYQLEAIDPYGQPFSADQHQAMAMQESADVEPNTVLKVFQKGYQLNGRLLRPAMVVVSKAPSPATPSINEQA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREG_CUPNH
Sequence: MTQARTKKNPPLRVGVGGPVGSGKTTLLEMLCKAMRDRYDLVAITNDIYTKEDQRLLTVSGALPAERIMGVETGGCPHTAIREDASINLEAVDRMLARFPDADVVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLVINKTDLAPYVGASLEVMESDARKMRGARPFVMGSVKSGQGLDEVIRFIERQGMLGV
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_ECOLI
Sequence: MQNQRIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHLRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes (PubMed:6759118).  Part of the processive rRNA transcription and antitermination complex (rrnTAC).  The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP).  It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis (PubMed:32871103).  In complex with NusB is involved in the regulation of ribosomal RNA (rRNA) biosynthesis by transcriptional antitermination.  S10 binds RNA non-specifically and increases the affinity of NusB for the boxA RNA sequence (PubMed:7678781, PubMed:11884128, PubMed:16109710).  S10 may constitute the critical antitermination component of the NusB-S10 complex (PubMed:19111659).
What are the official names of this protein?
30S ribosomal protein S10, Small ribosomal subunit protein uS10, Transcription termination/antitermination protein NusE.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: Y473_AQUAE
Sequence: MKEEREKKEEVFEEEEFGELLKYTLAGYAGGLGLGWLLDKLGFQQNPIGEWLVRTLAGEGESILEGIFAVKKRLTGAVSSLAQAYGWGKLIGMTVPWWIDLFSRLLGVNVYGWEGFYIPYFYAMSDQIGANVSGFIYLYKKEGNFSKAVKRYFTNPVMLTSLLVILLVPIGLLVARLLGFSPTTNFYAALETVAANLCWLPPLVGMLVEKKKGSD
What are the official names of this protein?
Uncharacterized protein aq_473.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DEF76_ARATH
Sequence: MQNQKHSHILTAITIVLLFAMAAKINAIDVHDAMCYRSECTSVCDQICLSHGYTNGWYCGTFRLHTGCCCLKKKELNQIISPSKN
What are the official names of this protein?
Defensin-like protein 76, Low-molecular-weight cysteine-rich protein 86, Protein LCR86.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: CRCB1_STAAM
Sequence: MHRQFLSSCCQNLFFKFKLLLFEVNQMQYVYIFIGGALGALLRYLISFLNTDGGFPIGTLIANLTGAFVMGLLTALTIAFFSNHPTLKKAITTGFLGALTTFSTFQLELIHMFDHQQFITLLLYAVTSYVFGILLCYVGIKLGGGLS
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PA2BG_LATLA
Sequence: MYPAHLLLLLAVCVSLLGASAIPPLPLNLIQFTYLIECANKGRRTSFNYADYGCYCGIGGSGTPVDKLDRCCKTHDECYAQAEKKGCYPKLTMYNYYCGGGGPYCNSKTECQRFVCDCDVRAADCFARYPYNNKNYNINTSNRCK
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 PC16, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ISDF_STAAB
Sequence: MMIKNKKKLLFLCLLVILIATAYISFVTGTIKLSFNDLFTKFTTGSNEAVDSIIDLRLPRILIALMVGAMLAVSGALLQAALQNPLAEANIIGVSSGALIMRALCMLFIPQLYFYLPLLSFIGGLIPFLIIIVLHSKFRFNAVSMILVGVALFVLLNGVLEILTQNPLMKIPQGLTMKIWSDVYILAVSALLGLILTLLLSLKLNLLNLDDVQARSIGFNIDRYRWLTGLLAVFLASATVAIVGQLAFLGIIVPHVVRKLVGGNYRVLIPFSTVIGAWLLLVADLLGRVIQPPLEIPANAILMIVGGPMLIYLICQSQRNRI
What is the function of this protein?
Part of the binding-protein-dependent transport system for heme-iron.  Responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Probable heme-iron transport system permease protein IsdF, Iron-regulated surface determinant protein F, Staphylococcal iron-regulated protein G.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DB119_GORGO
Sequence: MKLLYLFLAILLAIEEPVISGKRHILRCMGNSGICRASCKKNEQPYLYCRNYQSCCLQSYMRISISGKEEDTDWSYEKQWPRLP
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 119, Beta-defensin 120, Defensin, beta 119, Defensin, beta 120.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPPL3_HUMAN
Sequence: MAEQTYSWAYSLVDSSQVSTFLISILLIVYGSFRSLNMDFENQDKEKDSNSSSGSFNGNSTNNSIQTIDSTQALFLPIGASVSLLVMFFFFDSVQVVFTICTAVLATIAFAFLLLPMCQYLTRPCSPQNKISFGCCGRFTAAELLSFSLSVMLVLIWVLTGHWLLMDALAMGLCVAMIAFVRLPSLKVSCLLLSGLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPNVGRDVPRLSLPGKLVFPSSTGSHFSMLGIGDIVMPGLLLCFVLRYDNYKKQASGDSCGAPGPANISGRMQKVSYFHCTLIGYFVGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEPFHSKSSSSRFLEV
What is the function of this protein?
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571).  Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571).  Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).  May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852).  Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954).  Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).
What are the official names of this protein?
Signal peptide peptidase-like 3, SPP-like 3, Intramembrane protease 2, IMP-2, Presenilin homologous protein 1, PSH1, Presenilin-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus. Membrane; Multi-pass membrane protein; Lumenal side.
Protein: PANC_YERPY
Sequence: MLIIETLPLLRQQIRRWRQEGKRIALVPTMGNLHEGHMTLVDEAKTRADVVVVTIFVNPLQFERPDDLAHYPRTLQEDCEKLTRHGADLVFAPAAADIYPAGLEKQTYVDVPALSTILEGASRPGHFRGVSTIVSKLFNLIQPDVACFGEKDYQQLALIRKMVADMGYDINIVGVPTVRAKDGLALSSRNGYLTEEERQIAPQLSKIMWALAEKMALGERQIDALLEDAAAQLLRAGFTPDELFIRDAETLQPLTVDSQQAVILMAAWLGKARLIDNQLVDLRH
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_RICCK
Sequence: MARVTAEDCNKIIPDRFRLVVLATRYAKLLNYKVETSYSKKEKRDKPPVIALRRIAAGKVSVAQLEQDLINSLCTRNIIEPLANQDDLEDVEEKFDYLPEVYVGEDYSDLDDQIFIDENGEYDERDK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: FABZ_COXBR
Sequence: MNITDIKKYIPHRYPFLLIDRVIKIEKDKSLVAIKNVTVNEPFFTGHFPVRPVMPGVLIIESLAQAAGILIVKSLNLPEGHKDIYFFAGVDNARFKRVVEPGDQLTLEVKVLKVHRGLWKFEGKATVDDQLACKAELMTIKG
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMM1_PICST
Sequence: MADLETSDLSRVLPSSNLLSLEQLQEQLKRHRDELFQQQQDSHVLGSKPDDSLNNNYLLSHQYHDSQVYIPSNTWSFTQGLIVGQLSVVFVIVIFIKFFVFAESSPALAKSSITKDASVVIVKRDKKDQSSSDDADPDDDSETTASNAKVAAILEKTYYDVDNHSPESLDWFNVLVAQTIAQLRSEALLSDNIYHSLNNFLLKSELPEYLDKINLTEIDIGDDFPIFSNCRIKHSKDGSGRLEAKIDVDLSDTLTLGIETKLLLNHPRPLTAVLPVQLSVSMVRFSGCLTVSLINTADPEFAELSAHNSPEPGEPMSRSHSAGSPGGDSSHDEVISTPDSSSHTAQRKHSKDDPNDGTALMFSFSPDYRLEFTVKSLIGARAKLQDVPKISSLIENRLRAWFIERCIEPRFQVVRLPSLWPRRKNTREQVTNKNGDKVEDGSN
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Maintenance of mitochondrial morphology protein 1.
What is the protein family that this protein belongs to?
Belongs to the MMM1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.