PharMolix/UniProtQA huggingface dataset:
Protein: RH37_ARATH
Sequence: MSASWADVADSENTGSGSSNQNSHPSRPAYVPPHLRNRPAASEPVAPLPANDRVGYGGPPSGSRWAPGGSGVGVGGGGGYRADAGRPGSGSGYGGRGGGGWNNRSGGWDRREREVNPFENDDSEPEPAFTEQDNTVINFDAYEDIPIETSGDNVPPPVNTFAEIDLGEALNLNIRRCKYVKPTPVQRHAIPILLEGRDLMACAQTGSGKTAAFCFPIISGIMKDQHVQRPRGSRTVYPLAVILSPTRELASQIHDEAKKFSYQTGVKVVVAYGGTPINQQLRELERGVDILVATPGRLNDLLERARVSMQMIRFLALDEADRMLDMGFEPQIRKIVEQMDMPPRGVRQTLLFSATFPREIQRLAADFLANYIFLAVGRVGSSTDLIVQRVEFVLDSDKRSHLMDLLHAQRENGIQGKQALTLVFVETKRGADSLENWLCINGFPATSIHGDRTQQEREVALKAFKSGRTPILVATDVAARGLDIPHVAHVVNFDLPNDIDDYVHRIGRTGRAGKSGLATAFFNDGNTSLARPLAELMQEANQEVPEWLTRYASRSSFGGGKNRRSGGRFGGRDFRREGSFGSGRGGYGGGGGGYGGGGGYGGGGGYGGGGGYGGGYGGASSGGYGGEPPSAWD
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 37.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
Protein: RS6_CLOBL
Sequence: MRKYETVFILNPALDEEGYKANVEKFKGVIENAGGTVDNVDLWGKRKLAYEVKKVSEGYYTLMNFTADTELPKELDRVFRITDTVIRHMIITQE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: F241A_HUMAN
Sequence: MCSAGELLRGGDGGERDEDGDALAEREAAGTGWDPGASPRRRGQRPKESEQDVEDSQNHTGEPVGDDYKKMGTLFGELNKNLINMGFTRMYFGERIVEPVIVIFFWVMLWFLGLQALGLVAVLCLVIIYVQQ
What are the official names of this protein?
Uncharacterized protein FAM241A.
What is the protein family that this protein belongs to?
Belongs to the FAM241 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: THIG_STAS1
Sequence: MFKIGNFTLNSRLLLGTGKFDNEEIQTQAIAAAETEVLTFAVRRMNLYDKDLPNPLAKVDLSKFITFPNTAGAKTAKEAVRIAEIANHAGVCDMIKVEVIGDDETLLPDPLETYEACKVLLEKGYTVCPYISNDVVLAKRLEELGVHAIMPLASPIGTGRGINNPLNLRYIIERVNVPVIVDAGIGSPKDACHAMELGADGILLNTAISSAADPVKMAEAMNKGISAGRLSYEAGRIPVKYTAQASSPTEGIGFL
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_ALIF1
Sequence: MTTGKIVQIIGAVVDVEFPQGEVPRVYDALNVVDAQERLVLEVQQQIGGGVVRCIVMGSSDGLRRGLTVENTGAPISVPVGTKTLGRIMNVLGDAIDECGDIDAEEHYAIHREAPSYEEQSNSTELLETGVKVIDLVCPFAKGGKIGLFGGAGVGKTVNMMELINNIALQHSGLSVFAGVGERTREGNDFYFEMQEAGVVNIEKPEESKVAMVYGQMNEPPGNRLRVALTGLTMAERFRDEGRDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKQGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLNRNIAAMGLYPAIDPLDSTSRQLDPLVVGQEHYDIARGVQSTLQRYKELKDIIAILGMDELSEEDKQVVSRARKIEKFLTQPYHVAEVFTGDPGIYVPLKDTLAGFKGLLAGDYDDVPEQAFMYCGKIEDALEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y2901_MARN8
Sequence: MLYWAIVCLVIAVIAGILGFGGIAGTAAGFAKILFFVFLVLLVVSLVVNALRGKGPKV
What are the official names of this protein?
UPF0391 membrane protein Maqu_2901.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SECA3_MAGMM
Sequence: MFNLSLHGDPYPQQPGHLQLSWLDRMGERVRLAWMRHKQVNGWVLGRMAKRVLKAQTERESMTPEALREDLQRLTLALRRDGLEDALVEQAFAHVRLTAQRVLGMAHFPVQLKGGYIMLMGYLAEMDTGEGKTLTATLPAATAALAGFTVHVVTVNEYLARRDAQLMTPLYRALGVTTGVVTESMDSDEKQLGYRANVVYCTSKTLVFDYLRDRIQLGERMKPMAMAFDALVGGGRGQVMLQGLQYAIVDEADSIFVDEARTPLIISAPSKDASELAFLHTAWSLSQQLQQGQDYTLSGEEPPRITEAGSAQLAQLCVDLPPVWQGQHRREEAVAQALTAQHSFDRDVHYIIRDDKVMVVDETTGRVMPDRAWERGLQQLIEIKEGVAVTPPKETLAKISFQLFFRRFLRLSGMSGTCREVGGEIAEVYGLGVVRVAPNRPSKRKNLPIALYAWRAQADAAVVQAVRRCHMLGQPVLVGTRSIAASELLSQSFSEAGLPHRVLNAKQDQEENTIIAEAGYKGGITIATNMAGRGTDIKLSKEVQACGGLHVILTERHDNRRVDRQLAGRCARQGDPGSWQEILSLEDELTQKFLPLLGRTLRAWLALMPHFFLARWLGMVYYRWAQSYADRGHRRVRRQLMKTDFQLRQSLSFTGEME
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA 3.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: HEM6_PROM9
Sequence: MLKEPPKNSREKTKNLLLTLQDKICSGLENIDGKGKFTEESWLRDEGGGGRSRVLKNGSIFEQAGVNFSEVQGKELPQSIISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEAGPVWWFGGGADLTPFYPYLSDVRNFHKEHKKACEKVDKDLHKVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYRGNNQNGEASKVSENIGKSNLNWDNLFSLAENCGQAFLPSYLPIIEKRANKTYTSKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKKGSREEFLTSIFTKPQDWLNDKDLENFCMENNIFD
What is the function of this protein?
Involved in the heme and chlorophyll biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HN_PI3HV
Sequence: MEYWKHTNHGKDAGNELETSMATHGNKLTNKIIYILWTIILVLLSIVFIIVLINSIKSEKAHESLLRDINNEFMEITGKIQMASDNTNDLIQSGVNTRLLTIQSHVQNYIPISLTQQMSDLRKFISEITIRNDNQEVLPQRITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGLLAMPTTDDGCIRTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDLVPDLNPRISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASSGIEDIVLDIVNYDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGLEHPINENVICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVVDKGLNSTPKLKVWTISMRQNYWGSEGRLLLLGNKIYIYTRSTSWHSKLQLGIIDITDYSDIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLNPTGSIVSSVILDSQKSRVNPVITYSTATERVNELAIRNRTLSAGYTTTSCITHYNKGYCFHIVEINHKSLNTFQPMLFKTEIPKSCS
What is the function of this protein?
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
What are the official names of this protein?
Hemagglutinin-neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein.
Protein: CAPSD_BPG4
Sequence: MSNVQTSADRVPHDLSHLVFEAGKIGRLKTISWTPVVAGDSFECDMVGAIRLSPLRRGLAVDSRVDIFSFYIPHRHIYGQQWINFMKDGVNASPLPPVTCSSGWDSAAYLGTIPSSTLKVPKFLHQGYLNIYNNYFKPPWSDDLTYANPSNMPSEDYKWGVRVANLKSIWTAPLPPDTRTSENMTTGTSTIDIMGLQAAYAKLHTEQERDYFMTRYRDIMKEFGGHTSYDGDNRPLLLMRSEFWASGYDVDGTDQSSLGQFSGRVQQTFNHKVPRFYVPEHGVIMTLAVTRFPPTHEMEMHYLVGKENLTYTDIACDPALMANLPPREVSLKEFFHSSPDSAKFKIAEGQWYRTQPDRVAFPYNALDGFPFYSALPSTELKDRVLVNTNNYDEIFQSMQLAHWNMQTKFNINVYRHMPTTRDSIMTS
What is the function of this protein?
Assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins F.  Upon virus binding to host cell, one of the spikes dissociates from the capsid and the virus interacts with LPS through the exposed EF loops on the F proteins.  After the genome had been ejected, the channel formed by the F proteins at the unique fivefold axis remains open.
What are the official names of this protein?
Capsid protein F, F protein, GPF.
What is the protein family that this protein belongs to?
Belongs to the microviridae F protein family.
What are the subcellular locations of this protein?
Virion.
Protein: RS18_BURO1
Sequence: MARPTGKKFDKRRQQQNPLFKRKKFCRFTAAGVEQIDYKDTETLKDFIGENGKITPARLTGTKAHYQRQLDTAIKRARFLALLPYTDQHKA
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: WFDC5_AOTNA
Sequence: MRIQSLLLLGALLAVGSQPPAAFGRKKGEKPGACPPDDGPCLLSVPDQCMEDRQCPLTRKCCYRACFRQCVPRVSVKLGSCPEDQLRCLSPMNHLCHKDADCSGKKRCCSSACGRDCRDPVRG
What is the function of this protein?
Putative acid-stable proteinase inhibitor.
What are the official names of this protein?
WAP four-disulfide core domain protein 5.
What are the subcellular locations of this protein?
Secreted.
Protein: DIM1_DICDI
Sequence: MVKPVKIGVDAKVEKTKSATAARHHEFQMNKSYGQHLLKNPLIIDAIVDKSQLKSTDTVLEIGPGTGNLTMKLLENCKKVIAIEVDPRMAAELQKRVAASPYAQHLQIILGDFLKVDLPYFDVCVANVPYQISSPLTFKLLAHRPIFRTAVLMFQKEFALRLGAKPGDSLYCRLSVNTQLLSKVTHLMKVGKNNFLPPPKVESAVVRIEPFNPPPPINFVEWDGLVKLCFSRKNKTLSGIFRVSSVIETLNQNYKTYCALEGKMNTDGSDEQMKELIIKTLTDNDFLDSRSSKLDINDFLKLLNKFHETGIHFK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.  Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
Probable dimethyladenosine transferase, DIM1 dimethyladenosine transferase 1 homolog, Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase, Probable 18S rRNA dimethylase, Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus.
Protein: JIP5_YARLI
Sequence: MAKKETKHTPLTKLKFQDPIFGISFHPEQPRFVVGSSTGTVTAYKYSVDPQSATCGAPEVVWTTKRHKGSCRALIYSEDGSSVYSVGSDGVIKRADSQSGKVRAKNTESLPSTPSCIVRSEAYVAVGCEDGSIVAFDKTSLAEKHRAEGAHDGECVNALLELTHQNKHSFASLGSTTACVVDVRKGVKSTSDDQEDEILCGTMAAKDMGVCGMSQGQITTWTLGFNDQQNRVKLSEESIDAVIGAEDDYEVYAGGGEGIVWLANVKSGKKLDQFVHSRNDEVSFLDLDYQYRLVTASMNSLKLWPTADDEQKQAEVAAAKGAEEEQKAAPSGPPRKKHKKVKNKAHNPGVAHFGDL
What are the official names of this protein?
WD repeat-containing protein JIP5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: 3607L_ASFK5
Sequence: MNSLQVLTKKVLIENKAFSNYHEDDSFILQQLGLWWENGPIGFCKQCKMVISGSMSCSDVDSYELDRALVKAVKENQTDLIKLFVLWNADINYGIMCAKTERTKVLCIQLGANPEFLDNKKLYNMFVNLVRQQKVLLAIDIYYDNILILDSFGSHDFHALINFIYNGYILNLDEKEKMTRNTLVLKFWYKLAIEFNLIKPIRFLSKKFPHLDDWRLKTAVYLGNVDEIHHAYFQENIRLEPNHMMSLACMYPQNKLGIYYCFALGANINTALETLIRFINHEVYREITFFSNYGIWSNIHFCISLGANPDTKKIQETLLREEKNVIMKLLFKKGFLGPHSILHKKILEPSEVRKIISTYEYTETFHSFSSLRDNLR
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-7L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: RECF_SALPC
Sequence: MSLTRLLIKDFRNIENADLALSPGFNFLVGANGSGKTSVLEAIYTLGHGRAFRSLQPGRVIRHEQEAFVLHGRLQGEERETSIGLTKDKQGDSKVRIDGTDGHKIAELAHLMPMQLITPEGFTLLNGGPKYRRAFLDWGCFHNEAGFFTAWSNLKRLLKQRNAALRQVSRYEQLRPWDKELIPLAEQISTWRAEYSSAIAQDMADTCQQFLPEFSLTFSFQRGWEKETDYADVLERSFERDRMLTYTAHGPHKADFRIRADGAPVEDTLSRGQLKLLMCALRLAQGEFLTRESGRRCLYLIDDFASELDDARRGLLASRLKATQSQVFVSAISAEHVIDMSDENSKMFTVEKGKITD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLSO_ASFM2
Sequence: MLHWGPKFWRTLHLYAIFFSDTPGWKEKYEAIQWILNFIESLPCTMCRHHAFSYLTKNPLTLNNSEDFQYWTFAFHNNVNKRLNKKIISWSEYKNIYEQSILNTIEYGKTDFIGAWSSL
What is the function of this protein?
FAD-dependent sulfhydryl oxidase that catalyzes the formation of disulfide bonds in viral proteins produced in the cell cytoplasm (By similarity).  Involved in virion maturation (PubMed:10627538).
What are the official names of this protein?
FAD-linked sulfhydryl oxidase, p14.
What is the protein family that this protein belongs to?
Belongs to the asfivirus B119L family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion.
Protein: YL772_MIMIV
Sequence: MYYHIDSKSEIDCNDYLFFTDVTKVFSSTTYFANSYLFECLPNESDPEFKITKKSGGHIMKRFVINNKYPLDNVSTIEFLLDNGSLGVNFIVEWAFSKSNIDILRFFQERNITIPFEPKYSHATGELFKSKSVTIKYKHSSLLCNVRSTNKYQLIPREINYENLDVHRYVIDNYEYFGTYLYAYFFYESWIGKNELSLYILQTIKIDVDLILKDVIRVANITYIEMLVGYGAIINNDIFESAFKYQDVALVKYLIENYDIDYDLDKLIVESKNIEILQYLLSLGNKTISEYWEVY
What are the official names of this protein?
Uncharacterized protein L772.
Protein: SYH_RHIL3
Sequence: MNDKQKKPQKLKARLPRGFVDRTAGDIRAVNEMTAKIREVYEHYGFDPLETPLFEYTDALGKFLPDSDRPNEGVFSLQDDDEQWMSLRYDLTAPLARHVAENFNEIQLPYRTYRAGYVFRNEKPGPGRFRQFMQFDADTVGAPGVQADAEMCMMMADTLEALGIKRGDYVIRVNNRKVLDGVLEAIGLGGDDKAGQRLNVLRAIDKLDKFGPEGVALLLGPGRKDESGDFTKGAGLDKEQIDKVLFFVGITDYGESAVRLAELVAGTARGGEGVEELNFIGALVTSAGYGPDRIKIDPSVVRGLEYYTGPVYEAELTFDVTNEKGEKVVFGSVGGGGRYDGLVSRFMGQPVPATGFSIGVSRLMTALKNLGKLGASEVIEPVLVTVMDGDVEAMGRYQKMTQELRAAGIRAEMFQGNWKKFGNQLKYADRRGCPVAIIQGGDERATSVVQIKDLIEGKRLSGEIEDNASWREARVAQETAPEADLVAKVREILAAQAEDRKRAAYGFALPYDPAQVGDTDENA
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAN2_DROME
Sequence: MLRIRRRFALVICSGCLLVFLSLYIILNFAAPAATQIKPNYENIENKLHELENGLQEHGEEMRNLRARLAETSNRDDPIRPPLKVARSPRPGQCQDVVQDVPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPSVVHQTIMRGGAPEIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSELHPAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSAREDLDVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGTPEEHTQKLDVCHLLPNVARCERTTLTFLQNLEHLDGMVAPEVCPMETAAYVSSHSS
What is the function of this protein?
Catalyzes the first committed step in the biosynthesis of complex N-glycans.  It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity).
What are the official names of this protein?
Alpha-mannosidase 2, Golgi alpha-mannosidase II, AMan II, Man II, Golgi alpha-mannosidase IIa, Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 38 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: DICER_BOVIN
Sequence: MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFNRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVSASWTKEKWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKHIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDEEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGEADTEPVVDDDDVFPPYVLRPEDGPRVTINTAIGHVNRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMSCIRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRESYPRPGQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSLQMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPVDFRYPNLDFGWKKSIDSKSFISIANSSSAENENYCKHSTIVVPENAAHQGANRTSPLENHDQMSVNCRTLFSESPGKLQIEVSTDLTAINGLSYNKSLANGSYDLANRDFCQGNHLNYYKQEIPVQPTTSYPIQNLYNYENQPKPSDECTLLSNKYLDGNANTSTSDGSPVTAAVPGTTETGEAPPDRTASEQSPSPGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTVSLSALILDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNGLPPGYVVNQDKSNTEKWEKDEMTKDCMLANGKLDDDFEEEEEEEEDLMWRAHKEDADDEDDFLEYDQEHIKFIDNMLMGSGAFVKKISLSPFSATDSAYEWKMPKKSSLGSLPFSSDFEDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKAMCPTRENFTSQQKNLSGSRAAASGAGYRASVLKDLEYGCLKIPPRCMFDHPEADRTLRHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPEITKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS
What is the function of this protein?
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing.  Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs.  SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation.  Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance.  The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity).
What are the official names of this protein?
Endoribonuclease Dicer.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Dicer subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIAA_SALTY
Sequence: MLERIKVCFTESIQTQIAAAEALPDAISRAAMTLVHSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHHSARIQEMHMLTVNCLCDLIDNTLFPHQDD
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: GRAP1_RAT
Sequence: MAQALSEEEFQRMQTQLLELRTNNYQLSDELRKNGVELSSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSEKEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQLEQLELENRQLKEGVPGAAGPHVDGELLRLQAENTALQKNMAALQERYGKEAVRPSAVSEGQGDPPGDVLPISLSPMPLAEVELKWEMEREEKKLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADLKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSSQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQNTELAAELKHRQADYEELMGQKDDLNSQLQESLRANSRLLEQLQEMGQEKEQLIQDLQEARKSAEKRKVMLDELAMETLQEKSQHKEELGAVRLRHEKEMLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELENLQHTVEELQAQVHSMDGAKGWFERRLKEAEESLLQQEQEQEETLKQCREQHAAELKGKEEELQNVRDQLQQAQEERDGHVKTISNLKQEVKDTVDGQRILEKKGSAVLKDLKRQLHLERKRADKLQERLQEILTNSKSRTGLEELVLSEMNSPSRTQTGDSSSVSSFSYREILKEKESSAIPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVGSPDPDLEPGEAN
What is the function of this protein?
Functions as a scaffold protein in neurons to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.
What are the official names of this protein?
GRIP1-associated protein 1, GRASP-1.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, dendrite. Synapse. Note=Localizes to recycling endosomal tubules that are emanating from early endosomes.
Protein: FEN_THEKO
Sequence: MGVQIGELIPRKEIELESLYGKKVAIDAFNAMYQFLSTIRQRDGTPLMDSQGRITSHLSGFFYRTINLMEAGIKPAYVFDGKPPDFKKRELEKRREAREEAEEKWYEALEKGDLEEAKKYAMRATRVNEELINDAKKLLELMGIPVVQAPSEGEAQAAYMAAKKAVYASASQDYDSLLFGAPRLVRNLTITGRRKLPGKNVYVEVKPELVVLEEVLKELGIDREKLIELAILVGTDYNPGGIKGIGPKKALTIVKRTKDPLAKYQKESDVDLYAIKEFFLNPPVTDDYELKWREPDEEGILKFLCDEHDFSEERVKNGLERLKKAVKAGKQRTLESWFGR
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.