PharMolix/UniProtQA huggingface dataset:
Protein: DGTL1_ALIFM
Sequence: MNKPNEITLSPHWEDRISNEQKLRRNDQRSVFQRDRARILHSAAFRRLQAKTQVHGPGSANDFYRTRLTHSLEVSQIGTGVVAQLKLRQPEFRALLTSTSLMESICLAHDIGHPPFGHGGEIALNYMMRDHGGFEGNGQTLRILSKLEPYTEHFGMNLARRTLLGVLKYPAFLDQVHSTERPQEVSNVRHLKSIDWHPPKGVYRDDADILNWILKPLSDVDKALFSTFRFQQESQHTHRKTRFKSIDCSIMELADDIAYGVHDLEDAIVMGIVTRNQWQESVASKLAECGDEWFEANIETISDKLFSGLQYQRKDGIGSIVNALLTSITIKPTTFNDEPEFESELLRWNAFLSPSMSYALEVLKKFVGQFVIHNSEMQRIEYKGQQIVMEIFDALNSDPERLLPENDKREWREAKESGANAHRVIADYIAGMTDGYAQRLYNQLFVPI
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: GCH1_PYRAE
Sequence: MITDRKAKAKPERGVEELLEYLGEDLTKPGVLNTPKRFVKAMEELTRGLREPPPEVVFFPLEYDVELGPVVIENIGAVSLCEHHLLPILLRISVAYVPGDGVPGLSKVIRLVKWAAARPIMQERFTEWLADLLMEKLRAKGVQVKVCGVHMCSFIRGVKDEHHNMITEARRGEIDVKLSCKRPLGCR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: TRMD_BLOPB
Sequence: MLLGVITLFPDMFQSIVRYGIVGRAIRRGILSIKLWNPRLFTYDRHHSVDARPYGGGPGMLMMIEPLRNAINQAKDELGNNIKVIYLSPQGRKLKQKYVYKLAYDHQKLILVCGRYQGIDERLIQTEIDEEWSIGDYILSGGELAAMVLIDTISRVLPGVLGNQDSKESDSFSKERLDCPHYTRPETFDGMKVPSVLLSGNHDEIHRWKQKQALGRTWIKRPDLLNYIQLTNEEKNLLSEFKNEYLLSLNKKTRK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOXH_CUPNH
Sequence: MSRKLVIDPVTRIEGHGKVVVHLDDDNKVVDAKLHVVEFRGFEKFVQGHPFWEAPMFLQRICGICFVSHHLCGAKALDDMVGVGLKSGIHVTPTAEKMRRLGHYAQMLQSHTTAYFYLIVPEMLFGMDAPPAQRNVLGLIEANPDLVKRVVMLRKWGQEVIKAVFGKKMHGINSVPGGVNNNLSIAERDRFLNGEEGLLSVDQVIDYAQDGLRLFYDFHQKHRAQVDSFADVPALSMCLVGDDDNVDYYHGRLRIIDDDKHIVREFDYHDYLDHFSEAVEEWSYMKFPYLKELGREQGSVRVGPLGRMNVTKSLPTPLAQEALERFHAYTKGRTNNMTLHTNWARAIEILHAAEVVKELLHDPDLQKDQLVLTPPPNAWTGEGVGVVEAPRGTLLHHYRADERGNITFANLVVATTQNNQVMNRTVRSVAEDYLGGHGEITEGMMNAIEVGIRAYDPCLSCATHALGQMPLVVSVFDAAGRLIDERAR
What are the official names of this protein?
NAD-reducing hydrogenase HoxS subunit beta.
What is the protein family that this protein belongs to?
Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_COXBU
Sequence: MSLKIVFAGTPQFAVPTLRALIDSSHRVLAVYTQPDRPSGRGQKIMESPVKEIARQNEIPIIQPFSLRDEVEQEKLIAMNADVMVVVAYGLILPKKALNAFRLGCVNVHASLLPRWRGAAPIQRAILAGDRETGISIMQMNEGLDTGDVLAKSACVISSEDTAADLHDRLSLIGADLLLESLAKLEKGDIKLEKQDEASATYASKIQKQEALIDWRKSAVEIARQVRAFNPTPIAFTYFEGQPMRIWRATVVDEKTDFEPGVLVDADKKGISIAAGSGILRLHQLQLPGKRVCSAGDFINAHGDKLIPGKTVFG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: JARD2_DANRE
Sequence: MSKERPKRNIIQKKYDDNDGMPWSEERVVRKVLYLSLKEFKSAQKRQLCDGIDDEGKGPNASLSNGQLNGSKGGHKEDGSRSQRKDGGGEYSVDGPAKKRPRLHAQRKFAQSQPNSPSNTPVKMADPSLPTPLTHITFLSRRKPKTEDFLTFICLRGSPALPSNMAYFGCSQDEEDLEDEDEIEEEKAPSVASTSCQSTPKKGKPHGKINGLVLNGHKVHKDKELTPRSKARESSVGRDRSERCDESEISHKHTAATAKSHNTNGHNYRRAAEELRKQVSKVNGLTRASSVGTHKASGKKQKDFRLPSKTVKYTATVSKGHVTYTKAKRELVKKAKLNHSKHGASAGLRAYSNNHHHNSHHATSNGHGRPQLSHSGKAQSINAKTRKQVLLSNGVHKMTNGSRLNGRLNGRHSAREEEVVDRPVRQGLRNSKRRSDAMTLLGAVTESEETKTKQQTTEVKKAKVQPSPLETRSKKALNQFKSPNIVTIAHSITEMAASPIQKTGPAPPPSPPAAPASPSMPQNPAIPEPARQRPKRASAGKLMFIRKAQQRAQTNPTLNRTTSTTSASKSFKPAEPTHTPPPRLDRDRERERERERSRARYAALGDVPIFKPSSREFQDPLVYLDSFREQVESCGLCRVLPPTDWRPECKLNDEMRFVTQVQRIHKLGRRWGPNVQKLACIKKHLKSQGISMDQPPVIGKSFKSSAFRSAFVCIGGCEVDLARFSELVCDLGGMQQVMDLKKWSRLADLLRIPKSAQDRLAKLQEAYLQFLLSYDLLSPEELQRLEQEVRAEKEALERKRGPLEGHSDNGHHSLALPRYEPKNGLNGLSHRNGFRNHHKEPDIQRQAGRRRLFAQEKKGEKVECEETEEEMEDEGVLSDQHKCIYKGRSVSLTTFYRIARNTMMMYFNKEPGAAEVEQDYWRIVEQRDCHVAVHYGKVDTNTHGSGFPVGKSEPFSKHGWNLTVLPNNSGSILRHLGAVPGVTIPWLNIGMVFSTSCWSQDQNRLPYIDYLHTGADCIWYSIPAEEKTKLDKVVHTLLQANGTPGLEMLEKNVMISPEVLCREGIKVHRTVQQSGQFVVVFPGAFVSRVCCGYSVSETVHFATPQWMNLGYEAAKDLKCRRIAKPFSMEKLLYQIATAEAKRENRLVLSTISSLLKDLRNIEMKQRQELYEAGLLSSARYCTHDHNQSPADTRKKPRKWLALESSERRCQMCQHLCYLSMVVQENENVVFCLECALHYVEKHKNCRGLKMMYRYDEEQINSLVNQVCGKALVRSGSEVCNGSSPIKPPAKRGPRKRESMKITLIPLPTHPSKSAAAAVS
What is the function of this protein?
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development.  Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes.  Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells.  Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes.  In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development (By similarity).
What are the official names of this protein?
Protein Jumonji, Jumonji/ARID domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the JARID2 family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with the PRC2 complex on chromatin.
Protein: HSL7_DICDI
Sequence: MSILSALTSISNPMKSTKSSVANGGGRLSMGTNSVACGSCGGGNSSSGTINNADGSQTTYYSYTSPVYTYNYSYSYSSSGSSSCGCH
What are the official names of this protein?
HssA/B-like protein 7.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: RL14_CORU7
Sequence: MLQQESRVRVADNSGAREILVIRVLGGSVKRSAGIGDVVVATVKEAAPGGTVKENEIVRAVIVRTKKPTRRPDGSYIAFDENAAVIIKANDNDPRGTRIFGPVARELREKKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: LFTR_HYPNA
Sequence: MSARFGPEDLLACYRRGVFPMADSRDDPRLFLVDPDFRGILPLDAFHIPKRLKRRVCQDPYRVSFDTAFTRVVEACGEPHDNRPNTWINSPIVNLYSALHRQGFAHSVECWDGDQLVGGLYGVSLGGAFFGESMFSRATDASKIALVHLAARLIDRGYVLLDAQFHNPHLTQFGLIEISRDAFKARLKAALKVGADFHGGSDGPAPDQSIGMSSSGGVSDSVTPAGMSSYSGSSLSGMIARSGSFTGSGAVQRITQMS
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR3_ECOLI
Sequence: MNIVVLISGNGSNLQAIIDACKTNKIKGTVRAVFSNKADAFGLERARQAGIATHTLIASAFDSREAYDRELIHEIDMYAPDVVVLAGFMRILSPAFVSHYAGRLLNIHPSLLPKYPGLHTHRQALENGDEEHGTSVHFVTDELDGGPVILQAKVPVFAGDSEDDITARVQTQEHAIYPLVISWFADGRLKMHENAAWLDGQRLPPQGYAADE
What is the function of this protein?
Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
What are the official names of this protein?
Phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase, GAR transformylase, GART.
What is the protein family that this protein belongs to?
Belongs to the GART family.
Protein: PVK1_DERCR
Sequence: GSSGGLITFGRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, DerCr-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FPGT_MOUSE
Sequence: MASLREATLRKLRRFSELRGKPVAAGEFWDVVAITAADEKQELAYKQQLSEKLKKRELPLGVQYHVFPDPAGTKIGNGGSTLCSLECLESLCGDKWNSLKVLLIHSGGYSQRLPNASALGKIFTALPLGEPIYQMLELKLAMYVDFPSNMRPGVLVTCADDIELYSVGDSEYIAFDQPGFTALAHPSSLAVGTTHGVFVLHSDSSLQHGDLEYRQCYQFLHKPTIENMHRFNAVHRQRSFGQQNLSGGDTDCLPLHTEYVYTDSLFYMDHKSAKKLLDFYKSEGPLNCEIDAYGDFLQALGPGATAEYTRNTSHVTKEESQLLDMRQKIFHLLKGTPLNVVVLNNSRFYHIGTLQEYLLHFTSDSALKTELGLQSIAFSVSPSVPERSSGTACVIHSIVDSGCCVAPGSVVEYSRLGPEVSIGENCIISSSVIAKTVVPAYSFLCSLSVKINGHLKYSTMVFGMQDNLKNSVKTLEDIKALQFFGVCFLSCLDIWNLKATEKLFSGNKMNLSLWTACIFPVCSSLSESATASLGMLSAVRNHSPFNLSDFNLLSIQEMLVYKDVQDMLAYREHIFLEISSNKNQSDLEKS
What is the function of this protein?
Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate (PubMed:14686921).  Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids (Probable).
What are the official names of this protein?
Fucose-1-phosphate guanylyltransferase, GDP-L-fucose diphosphorylase, GDP-L-fucose pyrophosphorylase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_STAAM
Sequence: MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIRGKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKAEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGDITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDCPKCNQYLVENKKGKTTQVICSNCDYKEAAQK
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: VPS2A_ARATH
Sequence: MMNSIFGKRKTPAELLRENKRMLDKSIREIERERQGLQTQEKKLINEIKKTAKQGQMGAVKVMAKDLIRTRHQIEKFYKLKSQLQGVSLRIQTLKSTQAMGEAMKGVTKAMGQMNRQMNLPSLQKIMQEFERQNEKMEMVSEVMGDAIDDALEGDEEEEETEDLVSQVLDEIGIDINQELVNAPSGAVAVPAAKNKVVQAEATGAEDSGGIDSDLQARLDNLRKM
What is the function of this protein?
Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 2 homolog 1, AtVPS2-1, Charged multivesicular body protein 2 homolog 1, ESCRT-III complex subunit VPS2 homolog 1, SNF7-like protein.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Endosome.
Protein: RS17_SALHS
Sequence: MTDKIRTLQGRVVSDKMEKSIVVAIERFVKHPIYGKFIKRTTKMHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAVL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: HISJ_ECO57
Sequence: MKKLVLSLSLVLAFSSATAAFAAIPQNIRIGTDPTYAPFESKNSQGELVGFDIDLAKELCKRINTQCTFVENPLDALIPSLKAKKIDAIMSSLSITEKRQQEIAFTDKLYAADSRLVVAKNSDIQPTVESLKGKRVGVLQGTTQETFGNEHWAPKGIEIVSYQGQDNIYSDLTAGRIDAAFQDEVAASEGFLKQPVGKDYKFGGPSVKDEKLFGVGTGMGLRKEDNELREALNKAFAEMRADGTYEKLAKKYFDFDVYGG
What is the function of this protein?
Part of the histidine permease ABC transporter.  Binds histidine.  Interacts with HisQMP and stimulates ATPase activity of HisP, which results in histidine translocation (By similarity).
What are the official names of this protein?
Histidine-binding periplasmic protein, HBP.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 3 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HOA_NOVAR
Sequence: MTFDPTSDRLYIQDVTLRDGMHAILHMYGTDSVRTIAKALDEAGVDAIEVSHGDGLNGSTFNYGFGAHTDWDWIEAAADVIKNAVLTTLLVPGIGTAEELKRAYSMGVRSVRVATHCTEADVGKQHIGIARDLGMDVSGFLMMSHMIEPEALAQQALLMESYGAHCVYVTDSGGALDMDGVIARLQAYDRVLKPETQRGIHAHHNLSLGVANSIVAAQAGAVRIDASLAGMGAGAGNAPLEVFIAAANRKGWKHGCDVMALMDAADDIIRPLQDRPVRVDRETLSLGYAGVYSSFLRHAEKAAEQYGIDTREILVELGNRRMVGGQEDMIIDVALDLIKAKAN
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase, HOA, 4-hydroxy-2-keto-pentanoic acid aldolase, 4-hydroxy-2-oxopentanoate aldolase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: BH027_ARATH
Sequence: MEDLDHEYKNYWETTMFFQNQELEFDSWPMEEAFSGSGESSSPDGAATSPASSKNVVSERNRRQKLNQRLFALRSVVPNISKLDKASVIKDSIDYMQELIDQEKTLEAEIRELESRSTLLENPVRDYDCNFAETHLQDFSDNNDMRSKKFKQMDYSTRVQHYPIEVLEMKVTWMGEKTVVVCITCSKKRETMVQLCKVLESLNLNILTTNFSSFTSRLSTTLFLQVTLSLSPSLISLFGNVITSTNYKILNASREYCTCLVLV
What are the official names of this protein?
Transcription factor bHLH27, Basic helix-loop-helix protein 27, AtbHLH27, bHLH 27, Transcription factor EN 42, bHLH transcription factor bHLH027.
What are the subcellular locations of this protein?
Nucleus.
Protein: LOLB_PSYIN
Sequence: MKTFLPCLFFLLILVGCAQRPTPPATKTADWAAHQQQLNDLTDWSLRGKIAIITPENRHSLNIYWQQSGDNFHITLTSFLGSTILDVKKTALSTRIIDDQGKIYFGKNTQTLMTRLSGIELPVEVLQQWIKGNPIGAVYQLNENNQLVSLTGQDNKNENWSANYQDYKTVQEISLPHQLKLTRQDLLIKFAIQKWLLEKTEIF
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: KEX1_PARBD
Sequence: MGFSGSRAWSKWLTICLAITHPFSVTAKSAADYYVHSLPGQPEGPLLKMHAGHIEISPETSGNLFFWHFENRHIADKPRTVVWLNGGPGCSSEDGALMEIGPYRLIDKETLNYTEGSWDEFANLLFVDQPVGTGFSYGSTEHYVHELDEMASQFVTFLEKWFEIFPHYEPDDLYFAGESYAGQYIPYIARAVLDRNKKQDVQANNRIWNLKGLLIGNGWISPQHQYPAYLPYVYQEGVVQAGTQEANLIEAKAAKCMKELNVEDTTGTVHIPDCEDILQAILDYTHKGKRCINMYDIRLTDDYSACGMNWPPDLRDIQPYLRRKDVVKALHINEEKQTGWTECAGAVGSSLKARNSKPAVELLPGLLEEGLPILLFSGQKDLICNHVGTEDMIKNMKWSGGTGFELSPGVWAPRQDWTFEGEPAGIYQQARNLTYVLFYNASHMVPFDYPRRSRDMLDKFLGVDITHIGGDPADSRIDGEKGPTTSVGAHPNSTAAAEREKEKLNTAAWKAYYKSGEVALVIVAIAAFAWGIFIWRSRRKHQSSGYRSIYPMLGLNSTGSLGQISHKHSRRNGDIEAADFDETELDDQPSQAFLSRSSRDGDAYAVGEEGSDEEDGASDGQQPMFDQSRGEEGRS
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase KEX1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: SOPA_SALA4
Sequence: MKISSGAINFSTIPNQVKKLITSIREHTKNGFASKITSVKNTHASLNEKLKTGKSSSIEFALPQKIKDFFQPKDKNTLNKTLITVKNIKDTNNAGKKNISAEDVSKMNAAFMRKHIANQTCDYNYRVTGAAPLPGGVSVSANNRPTVSEGRTPPVSPSLSLQATSSPSSPAEWAKKLTDALLRQKAGETLTAADRDFSNADFRNITFSKILPTSFMKRDGDIIKGFNFSNSKFTYSDISHLHFDECRFTYSTLSDVVCSNTKFSNSDMNELTLQYSITTRQQPSFINTTLKNTFIRHKANLSGVILNEPDNSSPPSVSGGGNFIRLGDIWLQMPLLWSENAVDGFLNHEHNNGKSILMTIDSLPDKYSQEKVRAMEDLVKSLRGGRLTEACIRPVESSLVSVLAHPPYTQSALISEWLGPVQERFFAHQCQTYNDVPLPAPDTYYQQRILPVLLDSFDRNSAAMTTHSGLFNQVILHCMTGVDCTDGTRQKAAALYEQYLAHPAVSPHIHNGLFGNYDGSPDWTTRAADNFLLLSSQDSDTAMMLSTDTLLTMLNPTPDTAWDNFYLLRAGENVSTAQISPVELFRHDFPVFLAAFNQQATQRRFGELIDIILSTEEHGELNQQFIAATNQKHSTVKLIDDASVSRLATIFDPLLPEGKLSPAHYQHILSAYHLTDATPQKQAETLFCLSTAFARYSSSAIFGTEHDSPPALRGYAEALMQKAWELSPAIFPSSEQFTEWSDRFHGLHGAFTCTSVVADSMQRHARKYFPSVLSSILPLAWA
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway.
What are the official names of this protein?
E3 ubiquitin-protein ligase SopA, HECT-type E3 ubiquitin transferase SopA, Salmonella outer protein A, Secreted effector protein SopA.
What is the protein family that this protein belongs to?
Belongs to the SopA E3 ligase family.
What are the subcellular locations of this protein?
Secreted. Host cell. Note=Secreted via type III secretion system 1 (SPI-1 TTSS), and delivered into the host cell.
Protein: SYH_STAS1
Sequence: MINIPRGTQDILPNETKKWRFIEARLDELMEVYNYQEIRTPIFESTELFARGVGDSTDVVQKEMYTFKDKGDRSITLRPEGTAAVVRSYIENKMQGLPNQPIKLYYNGPMFRYERKQKGRYRQFTQFGVEAIGAENPGVDAEVLAMAMHIYQSFGLKHLKLVINSIGDIDSRHEYNEALVKHFEPVIGDFCSDCQSRLHTNPMRILDCKIDKDKEAVKTAPRITEFLNETSKQYYADVKQHLDDLGVPYVEDPNLVRGLDYYTHTAFELMIDNPNYDGAITTLCGGGRYNGLLELLDGPHQTGIGFALSIERLLLALDEENIELDTEHDFDLFIVTMGEEADRYAVKLLNDLRRNGVKADKDYLQRKVKGQMKQADRLNANYTIVIGEQELQENKINVKNMQTGESESVDLDKLVNYFKK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRRC3_DANRE
Sequence: MTFPAGAYVLRKVFIPHGCPLIFRLLLAVICLSVPSFACPKSCHCSERNSLTVVQCSSRNLEEIPPDLPHDTVSLQLSSNHITKIPNQAFKNLPWLQELDLSRNAIETVDAGAFKGVSESLRTLDLSHNHMQGVPKEAFARLHAKISLSNNPWHCECTLQEVLRELRLDPETVNEVSCHTSDQEKYAGKPVIQVLDSGINFCNFHHKTTDVAMFVTMFGWFTMVIAYVIYYVRHNQEDARRHLEYLKSLPSSSQISKDFDTISTVL
What are the official names of this protein?
Leucine-rich repeat-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the LRRC3 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: EGCSE_RHOH1
Sequence: MRKTVVAFAAAIAACSAVLSSTTTSAAPPATPITTLQADGTHLVDGYGRTVLLHGVNNVDKDAPYLPAGETLTPQDIDILVRHGFNTVRLGTSFDALMPQRGQIDEAYLDRLTGVVDALTARGMHVLLDNHQDGLSKAWGGNGFPEWAIESRPREWEPNPGFPLYYLMPSLNAGWDEVWGNTHGALDHLGTALGALAERVEGKPGVMGIELLNEPWPGSRFLSCFPNGCPDFDRTYQAAMQKLTDAVRAQNPTIPVYWEPNVTWNQMMPSNLFAPPVTPALTTADVVFAPHDYCIPSQLAIYLGLPQALRGLCVPQQDLTWSNIDAITERANVPTVITEFGDGDPTVLKNTLARADERFIGWQYWHFGAGNATDPFLGEVGRQLVRTYPQATAGEPGRMIFDADNGDFAYRFTPRAATRPTEIFVSDLHYPDGYAVQVDGGQVTSAPGARIVTVVADGSGPVTVKINRPGSAGAEVPDGPIETSSSGSSGSS
What is the function of this protein?
Hydrolyzes glycosphingolipids; exhibits broad substrate specificity including monosialodihexosylganglioside (GM3), monosialotetrahexosylganglioside (GM1), fucosyl-GM1, lactosylceramide, globotriosylceramide, globotetraosylceramide, ganglioside GD1a, and ganglioside GD1b (PubMed:28179425).  No activity towards glucosylceramide and galactosylceramide (PubMed:28179425).
What are the official names of this protein?
Endoglycoceramidase I, EGCase I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted. Membrane; Lipid-anchor.
Protein: SYH_ARCFU
Sequence: MKIERPRGTRDFLPDEMERRREIEKRMRKIAESFGYREVATPTFEYLELFTRKSGEGIIEEMYVFKDKSGRDLALRPELTAPVMRMFVNECSVMPKPLRFYYFANCFRYERPQKGRYREFWQFGVELIGSESYLADAEVIILADKILKDVGVNFSLEIGHVGIMRHLLKPIGEDRASKVMRLIDKGDREGLESYLAEIRVNEDLRDKIFSLLELKGDESVIEEAKEIIDYDFGHLESLSALLRDVGVDFTLNLGIARGLDYYTGVVFECYAEGLGAQKQVCGGGSYELSSLFGGPVTPSTGFAIGFDRVCEACSVEAGEKSVVAVVSFKGLESQAFRVASMLRERGFTAVVDVMGRNLKKQMSFASEMGVKYAVILGPDEVKSGRVAIKNLETQEQVVVAEEELFSILQ
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAA2_PELPD
Sequence: MKKHLNLLREFSVPLVAGVVVALFWANLDPAGYRAFDSTPFWGSLSFHFISNELFMTLFFGIAAVEITQSCMPGGDLNPISRAVNPLFGTLGGVLGPVLVYLGLNALVGLPELRNGWGIPTATDIALAWLAARMVFGPGHPAVSYLLLLAVADDAIGLAIIALFYPDPNHPVVAAWLLLTLLGMLVAWGLGRRRVRSYWPYILLGGSLSWIGLHQAHLHPALALVFIIPFLPHRLRESRHLFDDDPGDRSPLAQFEHEWKVVVDFGLFLFGLANAGVEFSSIGTVTWLVLVSLLVGKTVGIFGFGLLAERLGFRRPRGMKRRDLLVAGVVAGTGFTVALFVSGSAFSDPVIQAAAKMGAMFSLAAALIGMLLGQLLRIRKVH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 2, Sodium/proton antiporter NhaA 2.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KSR2_HUMAN
Sequence: MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
What is the function of this protein?
Location-regulated scaffold connecting MEK to RAF.  Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro).  Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126).  Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro).  Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling.  Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
What are the official names of this protein?
Kinase suppressor of Ras 2, hKSR2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.