PharMolix/UniProtQA huggingface dataset:
Protein: TISDA_XENLA
Sequence: MSATLLSAFYDIDLLYKNEKALNNLALSTMLDKKAVGSPVSSTNSNLFPGFLRRHSASNLQALSGSTNPAKFCHNNNNNQLNESAASSTALLNRENKFRDRSFSENGERSQHLLHLQQQQQKAGAQVNSTRYKTELCRPFEESGACKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRQAPGAGERPKLHHSLSFSGFPNHSLDSAPLLESPTSRTPPPQSSGSLYCQELLQLNNNNPCANNAFTFSGQELGLITPLAIHTQNSSYFRQPSSSPPLSFQPLRKVSESPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSDSPTLDSNRRLPIFSRLSISDD
What is the function of this protein?
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10751406, PubMed:12748283).  Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity).  Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity).  Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12748283).  Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (PubMed:10751406, PubMed:11279239).  Required for tubulogenesis during pronephros development (By similarity).
What are the official names of this protein?
mRNA decay activator protein ZFP36L2-A, CCCH zinc finger protein 3-A, XC3H-3, Zinc finger protein 36, C3H1 type-like 2-A.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.
Protein: DNAA_THET2
Sequence: MSHEAVWQHVLEHIRRSITEVEFHTWFERIRPLGIRDGVLELAVPTSFALDWIRRHYAGLIQEALGLLGAQAPRFELRVVPGVVVQEDIFQAAPAEAPRPKLNPKYTFENFVVGPNNSMAHAAAVAVAESPGRAYNPLFIYGGVGLGKTHLMHAVGHSVAKRFPHLKIEYVSTETFTNELINAIREDRMTEFRERYRSVDLLLVDDVQFIAGKERTQEEFFHTFNALYEAHKQIILSSDRPPKDILTLEARLRSRFEWGLITDIQPPDLETRIAILKMNAEQRGLRIPEDALEYIARQVTSNIRELEGALMRAIAFASLNGVELTRAVAAKALSDIFAPRELEADPLEIIRKVADHFGLKPEELTGSGRKKEVVLPRQLAMYLVRELTRASLPEIGQLFGGRDHTTVLYAIQKVQELAESDREVQGLLRTLREACT
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHLB_ECO81
Sequence: MSKTHLTEQKFSDFALHPKVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTSTFHYLLSHPAIADRKVNQPRALIMAPTRELAVQIHADAEPLAEATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMYDLGFIKDIRWLFRRMPPANQRLNMLFSATLSYRVRELAFEQMNNAEYIEVEPEQKTGHRIKEELFYPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILDEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIGHSIPVSKYNPDALMTDLPKPLRLTRPRTGNGPRRTGAPRNRRRSG
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GR_BACSU
Sequence: MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPMVNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVILRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF
What is the function of this protein?
Reduces glyoxal and methylglyoxal (2-oxopropanal).  Is not involved in the vitamin B6 biosynthesis.
What are the official names of this protein?
Glyoxal reductase, GR, Methylglyoxal reductase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: RS17_RHOPB
Sequence: MPKRTLQGVVVSDKQAKTVVVRVDRRFTHPIYKKTIRRSKNYHAHDENNEFKPGDVVWIEESKPISKLKRWTVVRGEQKKTA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RRF1_DESVH
Sequence: MPARILVVQEDPDIAAYLVSLFRQAGYKADAATEGPDAVEMVQASRPDVVFLDLALPQRWGPRFYSWMVTQPGCGNVPVVLVTDFAGLELMVPNAVGTVDKPFDPVLLLALVDRALATYAKGTPDTPDTTGAPAPDNR
What is the function of this protein?
May be involved in regulation of gene transcription.  Belongs to the family of response regulators, and members of this family involved in the regulation of gene transcription are two-domain proteins.  This protein contains only the N-terminal phosphorylation domain and not the C-terminal DNA-binding domain but it may bind to Rrf2 protein and the latter may bind to DNA.
What are the official names of this protein?
Protein Rrf1.
Protein: ISPG_HELPG
Sequence: MLENRVKTKQIFIGGVAIGGDAPISTQSMTFSKTADIESTKNQIDRLKLAGADLVRVAVSNEKDALALKELKKVSPLPLIADIHFHYKFALIAAQSVDAIRINPGNIGSKDKIKAVVDACKEKNIPIRIGVNAGSLEKQFDQKYGPTPKGMVESALYNAKLLEDLDFTNFKISLKASDVMRTIEAYRMLRPLVIYPFHLGVTEAGNLFSSSIKSAMALGGLLMEGIGDTMRVSITGELENEIKVARAILRHSGRLKEGINWISCPTCGRIEANLVDMASKVEKRLSHIKTPLDISVMGCVVNALGEAKHADMAIAFGNRSGLIIKEGKVIHKLAEKDLFETFVIEVENLAKEREKSLKD
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: BH084_ARATH
Sequence: MEAMGEWSTGLGGIYTEEADFMNQLLASYEQPCGGSSSETTATLTAYHHQGSQWNGGFCFSQESSSYSGYCAAMPRQEEDNNGMEDATINTNLYLVGEETSECDATEYSGKSLLPLETVAENHDHSMLQPENSLTTTTDEKMFNQCESSKKRTRATTTDKNKRANKARRSQKCVEMSGENENSGEEEYTEKAAGKRKTKPLKPQKTCCSDDESNGGDTFLSKEDGEDSKALNLNGKTRASRGAATDPQSLYARKRRERINERLRILQHLVPNGTKVDISTMLEEAVQYVKFLQLQIKLLSSDDLWMYAPIAYNGMDIGLDLKLNALTR
What are the official names of this protein?
Transcription factor bHLH84, Basic helix-loop-helix protein 84, AtbHLH84, bHLH 84, bHLH transcription factor bHLH084.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FKH_DROME
Sequence: MQKLYAEPPPSSAPVSMASSGGGGPPSGGGGGGGGGGGGGPPPPSNNNPNPTSNGGSMSPLARSAYTMNSMGLPVGGMSSVSPQAAATFSSSVLDSAAAVASMSASMSASMSASMNASMNGSMGAAAMNSMGGNCMTPSSMSYASMGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETGSPNSLGRSRVDKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAELCLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHPFSINRLLPTESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTSL
What is the function of this protein?
Fkh promotes terminal as opposed to segmental development.  In the absence of fkh, this developmental switch does not occur.  The nuclear localization of the fkh protein suggest that fkh regulates the transcription of other, subordinate, genes.
What are the official names of this protein?
Protein fork head.
What are the subcellular locations of this protein?
Nucleus.
Protein: COAT2_XANCP
Sequence: MARWCPPANRSASAAATCSSVVANTACMRWCKKRSQCPARRTP
What are the official names of this protein?
Phi-Lf prophage-derived putative minor coat protein.
Protein: PRIL_ARCFU
Sequence: MKYLPLYPILARYPFLRIASRVFSFNIEDELRKFLDTVEAAKRIVDKAIDGRVEYDRFTDESEFFCLGCEENCYDCQKRGTLEGCDLCMGCFENCSLYYPREAVERFYTNAKLSLLTYIASRMIVSAMEDWVRMRYAVNEASYYSRLLREDVEESGKEPIVRLVAIDLGAKLKGWKMHVSTFVRVSARIKDDKWRLVNRKLRNGWVETTKAEVLRGLEELLRMKLFEKVPVSEAVSEAVRELSRKAKRESEKFAMDLGEVDLNCLPPCMREILSELQRGMNIPHTARFAITSFLLNIGMTVDEIIALFKSAPDFDDEKTRYQVEHIAGERGKGAEYTSPSCDTMRTYSNCVADCRVSHPLIYYKKCKSKS
What is the function of this protein?
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase large subunit PriL.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase large subunit family.
Protein: SC31A_ARATH
Sequence: MDCIKSIGRSAFVAIAPESPFIAAGTMAGAVDLSFSSSANLEIFELDFQSNDRELKLVGQCQSSERFNRLAWGSYGSGSDGLIAGGLVDGNIGLWNPISSESGEIAHVRDLSKHKGPVRGLEFNVKSPNQLASGADDGTVCIWDLANPSKPSHYLKGTGSYMQSEISSLSWNKGFQHVLASTSHNGTTVIWDVNNEKIITDLKTTVRCSVLQWDPDHFNQILVASDEDSSPNVKLLDIRYLQSPVRTFVGHQRGVIAMEWCPSDSLYLLTCGKDNRTICWNTKTGKIVAELPTGQNWNFDVHWYPKMPGVISASSVDGKIGIYNLEGCSSYGTENQQHFLFHLLDADPLTAPKWWKRPAGASFGFGGKLISFNKNLPEASEVFLHSLATEKSLVNRISKFEAALENGEKTSLRGLCEKKTEEAESEEEKETWGLLKIMLEEDGNAKTKLRSHLGFSLPSEENDQTANEPHATCSSTNVEETQKVPEPEGEEEESSDPTFDDAIQRSLIVGDYKEAVAQCFSANKMADALVIAHVGGTELWESTRDKYIRMSNAPYMKVVSAMMNNDLMTYLHTRQPKSWKETLALICTFAEGDEWISLCDALASNLMAAGFTLAATLCYICAGNVDKTVDIWSMSLEKQSAGKSYAECVQDLMEKTLVLALTTCNKRVSASLRKLFESYAEILASQGLIATAMKFLKLLESGDFSPELSILRDRISLYAEPEAANTSASTNTQPKISNPYQEKSFTPAPLSNAQPSRSITFFPLNPPRELKNADQYQQPTMDYHSFNRSAGPAYNAPPGPGSYRSIHSQVGPYINSKIPQTVAPPVRPMTPTHQVAVQPEPVAPPPTVQTADTSNVPAHQKPIVASLTRLFKETFEPLRGYSRDTPAKKREAEDNCSRKLGALFSKLNNGDISKNAAEKLTQLCQALDKRDFGAALKIQGLMTSTEWDECSSWLPTLKKMIVTGRQNVR
What is the function of this protein?
Required for protein transport from the endoplasmic reticulum to the Golgi apparatus.
What are the official names of this protein?
Protein transport protein SEC31 homolog A, SEC31-like protein A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC31 family.
What are the subcellular locations of this protein?
Golgi apparatus. Endoplasmic reticulum.
Protein: SP1_POPEU
Sequence: IINDFTNLVNQVEPLK
What are the official names of this protein?
Protein SP1.
Protein: RAPA_ECOHS
Sequence: MPFTLGQRWISDTESELGLGTVVAVDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYSSEQFRMPYSGLRGQRTSLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNKLSNDELNMLGEMIGEQDIEPLLQAANSDSEDAQSARQELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFEGDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYNGLINYLASPDQTEGFDDLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQALAESIEEQDDDTNLIAFAMNLFDIIGINQDDRGDNMIVLTPSDHMLVPDFPGLSEDGITITFDREVALAREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELIYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLNAVNRHTGSKLVNAVQQDVHAILQLGEAQIEKSARALIDAARNEADEKLSAELSRLEALRAVNPNIRDDELTAIESNRQQVMESLDQAGWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: TNAA_CLOTE
Sequence: MIIYYLKLEGFNMKIKYVAEPFRIKMVEPIKMLTREERELKIAEAKYNTFNLRGEDVYIDLLTDSGTNAMSDDQWAGVMKGDEAYAGGKSYFKLVDAVKDIFGYKFVQPVHQGRAAEKVLFGLLLGEGKYSISNMHFDTTRAHVELSGARAIDCVVPEASDPTVRIPFKGNMDVEKLEKLIKEHGADKIGVVVMTITNNSAGGQPVSIENMKETAEICKKYNIRLCIDAARYAENAYFIKQREPGYENKSIKEIIKEIFSYADIFTMSAKKDAIVNMGGLLGIKEDEELFQLCKGRTISFEGFITYGGLSGRDLESLAIGLYEGIDENYLRYRIGQMEYLAARLDEAGIAYQSPVGGHGVFVDAKSMFPHIPYNEFPGQVLAVELYKEAGIRTCEIGSYMLGNDPDTGEQLKADFEFTRLAIARRVYTQAHIDIMADALITIKERANTVKGYRITWEPPILRHFQASLEPLK
What are the official names of this protein?
Tryptophanase, L-tryptophan indole-lyase, TNase.
What is the protein family that this protein belongs to?
Belongs to the beta-eliminating lyase family.
Protein: RL28_ACIAD
Sequence: MSKVCQVTGKRPVVGNNVSHANNKTKRRFEPNLHHHRFWLESEKRFVRLRLTTKGMRIIDKLGIEKVVADLRAQGQKI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: NDK_PSESM
Sequence: MAVQRTFSIIKPDAVAKNVIGEITTRFEKAGLRVVASKLKQLSKAEAEGFYAEHSARGFFGDLVAFMISGPVVVQVLEGENAIALNRELMGATNPKEAAAGTIRADFADSIDANAVHGSDSEAAAAREISYFFAATEVTAR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_ONYPE
Sequence: MSRKGHIKKRDVQPDPVYNSKLVTKIINIIMEDGKKGKAQTIFYQALKQVKTITNREPIKVFHEALNNIMPVLEVRTRRMGGQNYQVPSEVRPERRQSLGLRWIVKYTKESNEKTMEERLAKEIVDASLGNGVLVKKREETHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: IPYR_NOSS1
Sequence: MDLSRIPAQPKPGVINILIEIAGGSQNKYEFDKDLEAFALDRVLYSSVKYPYDYGFVPNTLADDGDPLDGMVIIDEPTFPGCVIAARPIGFLEMIDGGDRDEKILAVPDKDPRYAHVKSLNDVAPHRLDEIAEFFRSYKNLEKKVTQILGWQDVDQVKALVDQSIKAYK
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LALBA_TRIVU
Sequence: MMSLLPLLLIGIVLPATQAKDYGKCELNQILRERGVDKVISLPELICTMFHSSGFSTETEVDNNNHKEYGIFQISSNGWCAEKQEDVERSVCGILCSKLLDDDITDDIVCAKKILQLPERLDHWKAHNTFCRENLDQWNC
What is the function of this protein?
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme.  This enables LS to synthesize lactose, the major carbohydrate component of milk.  In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
What are the official names of this protein?
Alpha-lactalbumin, Lactose synthase B protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL35_PARP8
Sequence: MPKMKTKKSAAKRFVVRPGGTVKRGQAFKRHILTKKTTKNKRHLRGATAVHDSDLNSVRAMLPFA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RR14_PLAOC
Sequence: MAKKSLIQREKKRQKLEQKYHLIRRSSKKEISKIPSLSGKWEIHGKLQSLPRNSAATRLHRRCFSTGRPRANYRDFGLSGHILREMVHACLLPGATRSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MAP2_ARCFU
Sequence: MDDEVREKLIEAGKILKQAVNEAAEKIAPGVKILEVAEFVENRIIELGAKPAFPANISINSDAAHFTPKKNDERTFKEGDVVKLDVGAHIDGYIADMAVTVDLGDNTELVKAAKEALEAAMEVVRAGVSVSEIGKAIEDAITNYGFKPIVNLTGHGLLPYLNHAPPSIYNYATEKGVTLEEGMVVAIEPFATNGVGKVGERGECEIYSLLNPRPVRMKMAREILKEVEENYKTLPFAKRWLKKAPDIIISKLAREGVLRAYPVLTEVSGGLVSQWEHTLIVEDGGATITTK
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
Protein: MED7_DEBHA
Sequence: MTSTNEDIISSLYPPPPPYFKYFTEQNLNNLEIWKNKAQDEMQIDKTDLEQVKEDQDIKPPGELKFLVPPKQPDADHYRGFGNLWSFEDKLPGLKESGWTQLYKDDDELITSNTKIDELHKLMDSLLLNFLELIGVVSIDPQQFHYKIEDLKLILININHILNTYRPHQSRESLIMLLRKQIDMKRNEISEIDKTSEDIKSKILKLVDTSYIGDQEDAKCDNDSTEDEESIKNNIIQKLLNQNV
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 7, Mediator complex subunit 7.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: V_PI2H
Sequence: MAEEPTYTTEQVDELIHAGLGTVDFFLSRPIDAQSSLGKGSIPPGVTAVLTSAAEAKSKPVAAGPVKPRRKKVISNTTPYTIADNIPPEKLPINTPIPNPLLPLARPHGKMTDIDIVTGNITEGSYKGVELAKLGKQTLLTRFTSNEPVSSAGSAQDPNFKRGGANRERARGNHRREWSIAWVGDQVKVFEWCNPRCAPVTASARKFTCTCGSCPSICGECEGDH
What is the function of this protein?
Plays an essential role in the inhibition of host immune response.  Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway.  Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state.  Efficiently blocks type I IFN signaling following infection by targeting host STAT2 for proteasomal degradation.
What are the official names of this protein?
Non-structural protein V.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses V protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: FSR_METJA
Sequence: MYEWKLNEIVDSGVCARCGTCTIVCPNGILTFDERPKLIDECLRKGHGMCFEVCPRVSSAKYQIKIREKFYEKYYYAKSDIEGQDGGVVTAFLKYLLENGKIDGAIVVGDECWKPVSLVVQNAEDLLKTAKSKYAISTLDALRKAGEMGLEKVAVVGLPCQINGLRKLQYFPYHAKHDLELGRNGKPVKLPKIEYLIGLFCTEKFRYDNMKEVLSKHGIDIEKVEKFDIKKGKLLVYVNGEKKEFDLKEFEICSGCKMCRDFDAEMADVSVGCVGSPDGYSTIIIRTEKGEEIKNAVELKEGVNLEEIEKLRQLKLKRFKKEVERRRENNEYVSFYWTADYGGIGKRADGTYFIRVRAKPGGWYKPEEIKEILDIAEEYNAKIKVTDRAGYELHGISGFDVEDIVLRLREKGLLTGSEGPLVRATLACPGGGNCSSGLVDTTELARIIEDNFKERPAPYKFKIAISGCPNGCVRPQVHDIGIAGVKYPKVNEEKCNGCGRCAEVCKVEAIDIRGETSYTNYNVCVGCGKCIKNCPNEAREVKEEGYLVYVGGKTGREVVEGVKMKLMSVDEIINFIDKVLVVYGKYAEKPQRERLAAVMKRVGYGKFLEEVKELMKKEIC
What is the function of this protein?
Catalyzes the reduction of sulfite to sulfide using reduced F420 as the electron source.  Involved in sulfite detoxification and assimilation.  Cannot use NADH or NADPH.
What are the official names of this protein?
Coenzyme F420-dependent sulfite reductase, Sulfite reductase (coenzyme F420).
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: SYC_TREDE
Sequence: MSLKLHNTLGNKKEEFIPIHEGKAGVYGCGPTVYDYAHIGNLRTYVFQDILVKTLRFLGYDVTHVMNITDVGHLTDDEDSGEDKMVKSAEERGKSVLEIAEFYTKAFFNDTERLNIERPGIVCKATEHINEMIELIKRIEANGHTYMAGGNLYYDISTFPKYGELANINLEDLKAGARIEIDKNKRNPHDFVLWFTKSKFENQALVWDSPWGRGYPGWHIECSAMSMKYLGEQIDIHKGGIDHIRVHHTNEIAQSEGATGKKWVNYWLHNEFLVMNKGKMSKSAGSFIILEDVINKGFSALDYRFLLLGGHYRSQLTFSWEAMETAKNGRKNLNNRVAKWLDGLSDSEIMEYAALTENLNLKSAKDMIKNEKARSCFDNFIAAMEDDLSTPKALSELQLLIKEKDIPQKDVLTVLAAMDSILGIKLIEESFNTLKDKGSIEIDESEILKLIEERASAKLDKNYKLADEIRDKLKGMGIILEDQAGKTTWKKL
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1234_CLOAB
Sequence: MEVVIKISTTEAKKYLLIDTSVLPDVFEEVIQVKELLRSAKVKDITEAVKKVGISRSTYYKYKDYVFNVSDGLKSQKVTISILIEHRRGTLSEVLDKLAQRCCNILTINQDIPINNTANVNITFDISGISGDVKNIVEELKKIKNVLKVEIVAME
What are the official names of this protein?
UPF0735 ACT domain-containing protein CA_C1234.
What is the protein family that this protein belongs to?
Belongs to the UPF0735 family.
Protein: CP241_CANLF
Sequence: MDPVVVLVLCLSCCLLLSLWKQSSRKGKLPPGPTPLPFIGNILQLDKDINKSLSNLSKAYGPVFTLYFGMKPTVVLHGYDAVKETLIDLGEEFSARGRFPIAEKVSGGHGIIFTSGNRWKEMRRFALTTLRNLGMGKSDLESRVQEEACYLVEELRKTNALPCDPTFVLGCASCNVICSIIFQNRFDYTDQTLIGFLEKLNENFRILSSPWIQAYNSFPALLHYLPGSHNTIFKNFAFIKSYILEKIKEHQESFDVNNPRDFIDYFLIKMEQEKHNQPLEFTFENLKTIATDLFGAGTETTSTTLRYGLLLLLKHPEVTVKVQEEIDRVIGRHQSPHMQDRSRMPYTNAVLHEIQRYIDLVPNSLPHAVTCDVKFRNYVIPKGTTILISLSSVLSDEKEFPRPEIFDPAHFLDDSGNFKKSDYFMAFSAGKRICVGEGLARMELFLFLTTILQKFTLKPLVDPKDIDTTPLASGFGHVPPTYQLCFIPV
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 2C41, CYPIIC41.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.