PharMolix/UniProtQA huggingface dataset:
Protein: YO12B_YEAST
Sequence: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRPITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNSNKRIIAKLKMQYDTKIINLGESDDEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPNGRKLGAPGQPGLYINQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
What is the function of this protein?
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane.  Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
What are the official names of this protein?
Transposon Ty1-OR Gag-Pol polyprotein, Gag-Pol-p199, TY1A-TY1B, Transposon Ty1 TYA-TYB polyprotein, p190.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CMOB_CAMJ8
Sequence: MQENLLEKQFLNHPLYTKIQELKALNLACNFSLDDSVNLSTNSQAKDEILAITKELKPWRKGPFKIDDLFIDTEWQSFIKFNILKPFMNEISQKCVADIGCNNGYYMFKMLEFNPAKLIGFDPSIKYRLQFELINALAKTPIEYELLGVEDLPRYGLKFDVIFCLGVIYHRSDPIKMLKDLKAGLNKNGVVFLDTMYIEDEREIALVPNKTYSKIPNIYFVPSISALKNWCERAGFKEFEVLATKKTDENEQRKTEWIDSFSLENFLDPKDKNLTIEGYEAPKRVYVRIGI
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: SOX14_XENTR
Sequence: MSKPVDHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDHDPLKTGLSMSATDSLLGASEKARAFLPPTSAPYSLLDPSQFSSTTIQKMTEMPHTLAASTLPYASTLGYQNGAFGGLSCPSQHTHTHPSPTNPGYVVPCNCSAWSASNLQPPVAYILFPGMTKAGLDPYSSAHTAAM
What is the function of this protein?
Acts as a negative regulator of transcription.  May function as a switch in neuronal development (By similarity).
What are the official names of this protein?
Transcription factor Sox-14, SRY (sex determining region Y)-box 14.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECB_BRASO
Sequence: MTNGNGATPEAAPPPQLNVLAQYIKDLSFENPNAPQSLAPQGQPPQINIQINVGANALAETEYEVTLTIEGKAESGSQVMFSFELVYGGVFRLVNVPQEHLSPMLLIECPRLLFPFAREIVANSVRDGGFPPLMLDPVDFVSLYRQNMERQAAAQGVQGRPS
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSX2_CHICK
Sequence: MASPSKAKEVFSSDEEGPAAGAEEHHKVKVSSLPFSVEALMSDKKPPKELPLAAAGGSADGATVGTSRNLLLPGHGSRDAHSPPGALTKTFDTASVKSENSEDGTSWIQEAGRYSPPPRHLSPTACTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPIQAASLYGTSYPFHRPVLPIPPVGLYATPVGYSMYHLS
What is the function of this protein?
Acts as a transcriptional regulator in bone development.  Binds to DNA (By similarity).  Morphogenetic role.
What are the official names of this protein?
Homeobox protein MSX-2, Homeobox protein Hox-8, CHOX-8, GHox-8.
What is the protein family that this protein belongs to?
Belongs to the Msh homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACSL4_RAT
Sequence: MKLKLNVLTIVLLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVAKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWINYLEVNCRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKAALLDINCVKHIIYVDNKTINRAEYPEGLEIHSMQSVEELGSKPENSSIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTVHDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKKLTLLAQQKGVEGSWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLKDIERMYGGK
What is the function of this protein?
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804, PubMed:23766516, PubMed:9096315).  Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:9096315).  Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET (PubMed:23766516).  Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (PubMed:23766516).  Modulates prostaglandin E2 secretion (By similarity).
What are the official names of this protein?
Long-chain-fatty-acid--CoA ligase 4, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 4, LACS 4.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cell membrane.
Protein: TX124_LYCSI
Sequence: MMKVLVVVALLVTLISYSSSEGIDDLEADELLSLMANEQTRKECIPKHHECTSNKHGCCRGNFFKYKCQCTTVVTQDGEQTERCFCGTPPRHKAAELVVGFGKKIFG
What are the official names of this protein?
U1-lycotoxin-Ls1k, Toxin-like structure LSTX-A24.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 04 (U1-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ELF1_MOUSE
Sequence: MAAVVQQNDLVFEFASNGMEDEQQLGDPAIFPAVIVEHVPGADILNSYAGLACVEEPNDMITESSLDVAEEEIIDDDDDDITLTVEASCHNGDETIETIEAAEALLNIDSPSPPVLDEKQINNNIFSSSEDDIVAPITHVSVTLDGIPEVMETQQVQETNADSPGASSPEQRKRKKGRKTKPPRPDSPTTTPNISVKKKNKDGKGNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKLVDSKAVSRLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLIYIDDEDPSSSIESSDQSLSSTTASSRNQANRSRVSSSPGIKGGAATILKPGNSKAANPKDPVEVGQPSEVLRTVQPSQAPYPTQLFRTVHVVQPVQAVPEEATIASTMQEEAANSSVPSIRTIQASTQVPVVVSPGNQQLHTVTVPLTTVIASIDPSSGAGSQKFILQTIPSSQPMTVLKENVMLQSQKPGSPSIVLSPTQVQQVLTSNVQSICNGAGSVASAPSFSATTPVVTFSRSSQLVAHPPGTVITSVIKAQETKTLKQEVEKKAEDDLNEDAEKSAQQPQPYVMVLSSSNGFSSQVAVKQNELLEPNSF
What is the function of this protein?
Transcription factor that activates the LYN and BLK promoters.
What are the official names of this protein?
ETS-related transcription factor Elf-1, E74-like factor 1.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL10_RICFE
Sequence: MLRSEKPVAVEDIVNIYKESPSVIITHYHGLTVSQVSSLRDSLKSKEAGFKVVKNTLAKIAANQTGLDSIANLFAGPTAIVYSKEPVEMAKLVVNFAKANDNLKIIGGIVDNHVLDEHSIKELSKLPSLNELRGKIVGLLQAPATKVVGVLQAPSSSMARVIQAHASKN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RL7_MYCPA
Sequence: MAKMSTDDLLDAFKEMTLLELSDFVKKFEETFEVTAAAPVAVAAAGPAAGGAPAEAAEEQSEFDVILESAGDKKIGVIKVVREIVSGLGLKEAKDLVDGAPKPLLEKVAKEAADDAKAKLEAAGATVTVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: COSH_THITI
Sequence: MEKSNTDALLENNRLYAGGQATHRPGHPGMQPIQPSRRVAVVACMDARLDVEDLLGLQTGEAHIIRNAGGVINEDAIRCLIISHHLLNTHEIILVHHTRCGMLAFTDDLLRAGLEGDAAAEKLIGQATGRAFVSAGKASASPAAFQAFRGPPEPLDAPRSDASTERIAADVRRGLSIILNHPWLPTAGPDAITVRGFIYDVDTGRLEEVSYPGPMGGFG
What is the function of this protein?
Catalyzes the degradation of carbonyl sulfide (COS) to hydrogen sulfide and CO(2) (PubMed:23406161, PubMed:29199215).  May function as one of the microbial sinks for ambient COS, which is an atmospheric trace gas leading to sulfate aerosol formation, thereby participating in the global radiation balance and ozone chemistry (PubMed:23406161).  Shows little CO(2) hydration activity and poor carbon disulfide (CS(2)) hydrolysis activity (PubMed:23406161).
What are the official names of this protein?
Carbonyl sulfide hydrolase, COSase.
What is the protein family that this protein belongs to?
Belongs to the beta-class carbonic anhydrase family.
Protein: NQRB_VIBC1
Sequence: MLKKFIEDIEHHFEPGGKHEKWFALYEAAATLFYTPGLVTKRSSHVRDSVDLKRIMIMVWFAVFPAMFWGMYNAGGQAIAALNHMYAGDQLATVIAGNWHYWLTEMLGGTIGAEAGVGSMMLLGATYFLPIYATVFIVGGFWEVLFCMVRKHEVNEGFFVTSILFALIVPPTLPLWQAALGITFGVVVAKEIFGGTGRNFLNPALAGRAFLFFAYPAQISGDVVWTAADGFSGATALSQWAHGGSGALINNITGAPITWMDAFIGNIPGSIGEVSTLALMIGAAMIVYMRIASWRIIAGVMIGMIAVSTLFNVIGSDTNPMFNMPWHWHLVLGGFAFGMFFMATDPVSASFTNSGKWWYGILIGAMCVMIRVVNPAYPEGMMLAILFANLFAPLFDHVVIEKNIKRRLARYGK
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit B, Na(+)-NQR subunit B, Na(+)-translocating NQR subunit B, NQR complex subunit B, NQR-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YNFB_SALPC
Sequence: MNNTLSKRLCLTAMLTLAAVVYTTSAFAETSKLVIESGDSAQSRQEAAMEKEQWNDTRSLRQKVNTRAEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVITP
What are the official names of this protein?
UPF0482 protein YnfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: PLSB_ECO57
Sequence: MSGWPRIYYKLLNLPLSILVKSKSIPADPAPELGLDTSRPIMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGTLLPRYVFIHGGPRVFTYYTPKEESIKLFHDYLDLHRSNPNLDVQMVPVSVMFGRAPGREKGEVNPPLRMLNGVQKFFAVLWLGRDSFVRFSPSVSLRRMADEHGTDKTIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASRAIAKAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRLYQGINVHNAERVRQLAHDGHELVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLIPIYIGYEHVMEVGTYAKELRGATKEKESLPQMLRGLSKLRNLGQGYVNFGEPMPLMTYLNQHVPDWRESIDPIEAVRPAWLTPTVNNIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTEQLNCYLDLMRNVPYSTDSTVPSASASELIDHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLVLPSLMAAIVTQHRHISRDVLMEHVNVLYPMLKAELFLRWDRDELPDVIDALANEMQRQGLITLQDDELHINPVHSRTLQLLAAGARETLQRYAITFWLLSANPSINRGTLEKESRTVAQRLSVLHGINAPEFFDKAVFSSLVLTLRDEGYISDSGDAEPAETMKVYQLLAELITSDVRLTIESATQGEG
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RBFA_THEFY
Sequence: MVDAARASKLADRIQRIVAEMLERRIKDPRLGFVTVTDARLTNDLRDATVYYTVFGSDAEKAATAAALESAKGLIRSEVGRRTGLRHTPTITFVIDEVPDNARHIEELLAKAKQADAEVARAAANARPAGDPDPYREPRPADDDDEDDEDE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAA_SALG2
Sequence: MSIKEQSLMTPYLQFDRSQWAALRDSVPMTLTEDEIAQLKGINEDLSLEEVAEIYLPLSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRRVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPVYSHLIYDVIPEGDKTVAQPDILILEGLNVLQSGMDYPHDPHHVLVSDFVDFSIYVDAPEELLQTWYINRFLKFREGAFTDPDSYFHNYAKLSKEEAVNTATSLWKEINWLNLKQNILPTRERASLIMTKSANHAVEQVRLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_MYCBP
Sequence: MARADKATAVADIAAQFKESTATLITEYRGLTVANLAELRRSLTGSATYAVAKNTLIKRAASEAGIEGLDELFVGPTAIAFVTGEPVDAAKAIKTFAKEHKALVIKGGYMDGHPLTVAEVERIADLESREVLLAKLAGAMKGNLAKAAGLFNAPASQLARLAAALQEKKACPGPDSAE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: Y905_MYCBO
Sequence: MTEGRCAQHPDGLDVQDVCDPDDPRLDDFRDLNSIDRRPDLPTGKALVIAEGVLVVQRMLASRFTPLALFGTDRRLAELKDDLAGVGAPYYRASADVMARVIGFHLNRGVLAAARRVPEPSVAQVVAGARTVAVLEGVNDHENLGSIFRNAAGLSVDAVVFGTGCADPLYRRAVRVSMGHALLVPYARAADWPTELMTLKESGFRLLAMTPHGNACKLPEAIAAVSHERIALLVGAEGPGLTAAALRISDVRVRIPMSRGTDSLNVATAAALAFYERTRSGHHIGPGT
What are the official names of this protein?
Uncharacterized tRNA/rRNA methyltransferase Mb0905.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: AROA_BACAC
Sequence: MKERTIQPVNNGLNGNITIPGDKSISHRAVMFGAIAEGTTTIKGFLPGADCLSTISCFKEMGVDIVQNGDEVTVVGKGLEGLQEPKAVLDVGNSGTTIRLMSGILANTPFLSCVQGDTSIAKRPMKRVTNPLKQMGANIDGREEGTFTPLTIRGGDLKAIEYTSPVASAQVKSAILLAGLRAEGVTAVTEPHISRDHTERMLEAFGVKVTREGKTVKLAGGQKLTATDVQVPGDVSSAAFFLVAGAIIPNSKLVLENVGMNPTRTGIIDVLEKMGATFTVEPINEGASEPAANITIETSSLKGIEIGGDIIPRLIDEIPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDRMIIYGKSALKGNTVNSYGDHRIGMMLAIAGCIAEGKTIIEDAEAVGVSYPTFFEELQKLAK
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IP5PE_ARATH
Sequence: MDSVIIEPDEREALASLVPAHPLPPRKTHSYVEQCEQKPHHPIRKYSLDEGSRSVTSDSEAVYFDSSDGEFSTEGVAIVDGRTSGERGNGEECGFVTPPSKPASQGGGNDGGREDDIESLPEFIGAGGGLDVFKVPVRAAVNPGRPPCLELRPHPLRETQTGKFLRNIACTESQLWAGQENGVRFWNLEEAYEVGCGLGGQVRRGDEDTAPFHESVPTSPALCLLVDHGNRLVWTGHKDGKIRAWKMNQPNTTTADDSKPFKERLSWQAHRGPVNYIVISSYGDMWSCSDGGVIKIWTLDSLEKSLVLKLEEKHMAALLVERSGIDLRSQVTVNGTCSISSSDVKFLLVDTVKAKVWAVQHLSFSLWDAQNKELLKVFNIDGQVENRVDMPPTQGQQVEDTKAKFFSAPKKEKSQGFLQRSRHAIMGAAGAVRRAATRSAGAFAEDTRKVEAIAIAADGSIWTGSMNGVIAQWDGNGSRLREVNHHQQAVLCFCTFGDRIYVGYSSGYIQVLDLGGKLIASWVSHNEPVIKLAAGGGFIFSLATHGGVRGWYVTSPGPLDSLIRTELSQKEMAYARQDSVKILIGTWNVGEGRASRGALVSWLGSAVSDVGIVAIGLQEVDMGAGFLAMSTAKETVGVEGSAVGQWWLDAIGNALDERNTFERMGSRQLAGLLISLWVRKSIRTHVGDLDVAAVPCGFGRAIGNKGGVGLRIRVYDRIMCFVNCHLAAHLEAVTRRNADFNHIYRSMVFSKGQSVYTAAAAGASTSAQALKNNPNTNNSTEEEKSHLASADLVAFFGDFNYRLFGITYDEARDFISHRSFDWLREKDQLRQEMNEGKVFQGMREALITFPPTYKFEKNKPGLGGYDSGEKKRIPAWCDRVIYRDNQSISYTECSLKCPVVSSTIMYEACMDVTESDHKPVRCKLHANIAHTDKSVRRQELGKIVKSNEKLRAMFEELKSVPETSVSTNNILLHSQDTFIFTIRNTSNSSRAIFNIVCKGQTLVREDGEEPDNHSRGTFGLPRWLEVSPGAGIIKPDASLQVKVHHEDSHNSEEFIDGIQQNSLSEESSDKEVTLIIIVQGSCSTRTISHSIKVRHCSSAAKSLSLVHSKTTTMTKNLEGSTRYQTDANRGGSTRHRTDDSTRRG
What is the function of this protein?
Has phosphatase activity toward PtdIns(4,5)P2, PtdIns(3,4,5)P3 and Ins(1,4,5)P3.
What are the official names of this protein?
Type II inositol polyphosphate 5-phosphatase 14, At5PTase14.
What is the protein family that this protein belongs to?
Belongs to the inositol polyphosphate 5-phosphatase family.
Protein: SYD_PHOLL
Sequence: MRTDYCGQLNLTHEGQKVTLCGWVNRRRDLGGLIFIDMRDREGIVQVFFDPDQQAAFSQAAELRNEFCIQITGTVRARPDSQINKDMATGEIEVFAESLNIINRSEPLPLDSNQTNSEEQRLKYRYIDLRRPEMANRLKTRAKITSFVRRFMDNQGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAEQVREMMEKMIRELWFEIDGVDLGHFPVMTFAEVMRRFGSDKPDLRNPLELVDVADLVKDVEFSVFAEPANDSKGRVAVIRVPGGAELSRKQIDEYGKFVGIYGAKGLAWIKVNARAAGLEGVQSPIAKFLNAEVIEGLLSRTDAQDGDILFFGAGSVKVVTDALGALRLKLGRDLNLTKLDSWRPLWVIDFPMFEDDGEGGLTAMHHPFTSPCNMSAAELAQDPVSAIANAYDMVINGYEVGGGSVRIHRNEMQQAVFRILGINEQEQQEKFGFLLDALKFGTPPHAGLAFGLDRLVMLLTGTDNIRDVIAFPKTTAAACLMTEAPSYANPASLEELSISVVAKKESE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAT_HV1Z8
Sequence: PSSQPRGDPTGPKE
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Tat seems to inhibit the HAT activity of KAT5/Tip60 and TAF1, and consequently modify the expression of specific cellular genes.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines (such as IL10) or cytokine receptors.  May be involved in the derepression of host interleukin IL2 expression.  Mediates the activation of cyclin-dependent kinases and dysregulation of microtubule network.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Host extracellular matrix metalloproteinase MMP1 cleaves Tat and decreases Tat's mediated neurotoxicity.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.  Binds to KDR/VEGFR-2.  All these Tat-mediated effects enhance angiogenesis in Kaposi's sarcoma lesions (By similarity).
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type (By similarity).
Protein: PDHR_ECOL6
Sequence: MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSFSDPLVELLSDHPESQYDLLETRHALEGIAAYYAALRSTDEDKERIRELHHAIELAQQSGDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFELLYSRREMLPLVSSHRTRIFEAIMAGKPEEAREASHRHLAFIEEILLDRSREESRRERSLRRLEQRKN
What is the function of this protein?
Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd.
What are the official names of this protein?
Pyruvate dehydrogenase complex repressor.
Protein: IF3_THET8
Sequence: MKEYLTNERIRAKQVRVVGPDGKQLGIMDTREALRLAQEMDLDLVLVGPNADPPVARIMDYSKWRYEQQMAEKEARKKAKRTEVKSIKFRVKIDEHDYQTKLGHIKRFLQEGHKVKVTIMFRGREVAHPELGERILNRVTEDLKDLAVVEMKPEMLGRDMNMLLAPVKVSA
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TR1L1_MOUSE
Sequence: MGLRKKNARNPPVLSHEFMVQNHADMVSCVGMFFVLGLMFEGTSEMSIAFLTLQHGVVVPAEGLPSGSRTLYHYGVKDLATVFFYMLVAIIIHATIQEYVLDKLSRRLQLTKGKQNKLNEAGQLSVFYIVSGIWGMIILASENCLSDPTLLWKSQPHNMMTFQMKFFYISQLAYWFHSFPELYFQKVRKQDIPGQLIYIGLHLFHIGGAYLLYLNHLGLLLLMLHYAVELLSSVCSLLYFGDERYQKGLSLWPIVFISGRLVTLIVSVVTVGLHLAGTNRNGNALSGNVNVLAAKIAVLSSSCSIQVYITWTLTTVWLQRWLEDANLHVCGRKRRSRARKGTENGVENPNRIDSPPKKKEKAP
What is the function of this protein?
Stimulatory or required for the translocation of secretory proteins across the ER membrane.
What are the official names of this protein?
Translocating chain-associated membrane protein 1-like 1.
What is the protein family that this protein belongs to?
Belongs to the TRAM family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.