PharMolix/UniProtQA huggingface dataset:
Protein: Y570_MYCPN
Sequence: MKQKIIGLTLAFFVLFLTAVAILFTVKVQRYLTTSLWAKLSEQTFLVFKNEQDEAQFNQVSWTNFQAETTKKEDKKAFRLYKKKISLEQLENENQQQLFQAVNLSINLKQGWYNITILLPSKALFETVF
What are the official names of this protein?
Uncharacterized protein MG389 homolog.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RLMN_PSYA2
Sequence: MSTVQTPVQYLPAKTANSIKLVDEAQAKTNLLGMTQAQLADYFKSIGEKPFRSTQVIKWIYQQGVTDFEQMTNLSKSLRDKLSANACVIPPKVIHRQYSDDGTRKWVFEVTGGSLVETVLIPADDSKLNGRKTLCISSQVGCALDCSFCSTGKQGFERDLTAAEILGQLWVANASYMSDENDSLENIDHSLWENNVTNVVMMGMGEPLLNYRPVVSSMELMLSDHAYGLSKRRVTLSTSGVVPKMYELAKELDVALAISLHAPNDELRNELVPINKKYPLEQLMAAARNYVFDVNPRHKKHVTIEYVMLDGVNDSNEHAEQLVALLGDLPSKINLIPFNPFPHANYDKSSNNRIHAFSNILSEAGFVCTIRQTRGDDIDAACGQLVGQVADRTRRSAAWQQSIKDRENS
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRR33_ARATH
Sequence: MFSSYSLCKCLVSFHILAIQVLISCASSLNLTNEYLNHKCRKYQPGSEYEKELNTLSRRVATLDFTDGFTHRSNSRDTKSVTIIFQCRGDSYRSKCNSCYATALAGFRSRCPRNKGGIIWYDQCFLDVSMINDNSPRRMNYDNIFSMHNPNNVRGNVNSFNKKTTEFLYKLIGKADRLDVDGINFLYYAAGEMRLGKQTLFAMVQCAKDILSCKDCLEWSIKELSKCCDGKQGARVVGTICNLRYELYPFLRT
What are the official names of this protein?
Putative cysteine-rich repeat secretory protein 33.
What is the protein family that this protein belongs to?
Belongs to the cysteine-rich repeat secretory protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: C5AR1_HUMAN
Sequence: MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
What is the function of this protein?
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009).  The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099).  Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
What are the official names of this protein?
C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
Protein: NUSB_METFK
Sequence: MPAEAKKPAPKAGRSRRKSRELVLKGIYLGLMNQKDTSVIIRELADDPDFDRADYEYFRQLLEGVAESIDELDARLAGLLDRQVSELSPIEHAILCIAAYELIHDVTIPYRVAINEGVELAKLYGGTDGHKYVNGVLDKIAAEARPDEFQRGRR
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: SURA_ALBFT
Sequence: MNHRLVALSVASLALLAPLTVPAQGLRPSSATVGAGVLAPARVPAATGLAADYIVAVVNSEPITNNEVRAALQRVLQQLAQQGNPQVDSKTLVRQVLERLINEKAQLQLARESGIAADEAAIDQAEQNIARQNQLTVAELRRRLTQEGGVPGQFRNQLRDQILLTRLREREVEPRARVSELEIDQFLREQQSSTPAVQQINLAQVLVSVPDTATPVQVTALQARAQRALARARAGEDFVTLVREFSDASDKASLANGGELGLRTADRYPPLFLEATHNLAVGEISALVRSGAGFHILKVLEKKSAALPAMTVTQSRARHILLRVSPQLTESAARDKLNEFKKRVAAGQADFAALARDHSQDGSAAQGGDLGWANPGMFVPEFEAVMNSLTPGQISEPLVSRFGVHLIQLMERRQATLSPQEQREAVRAMLHEKKLDEAYISWAQDVRGRAYVELREPPQ
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: MRPP3_HUMAN
Sequence: MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQLSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLLLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDEDLVERCSCEVPTKWLCLHQKT
What is the function of this protein?
Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011).  The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853).
What are the official names of this protein?
Mitochondrial ribonuclease P catalytic subunit, Mitochondrial ribonuclease P protein 3, Mitochondrial RNase P protein 3, Protein only RNase P catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: DCUP_TROW8
Sequence: MTGASGVEGTRIPLHSLSCRPSAGRSAGSFVNTGIMEAFRGTRPGCLPVWFMRQAGRSLPEYRAVRGTNTLLEACLNPDLACEITLQPVRRYSVDAAILFSDIVVPLKLAGVGVDILPGTGPVLNNPIDTPDRVNTLLAKTADSIDFGIIAEITRHTVSVLNGIPLIGFAGAPYTLACYMVEGGPSKTHMKARAMMHGDKKTWQKVMMLAARLSGQFLAAQITSGAQAVQIFDSWAGSLSRKDYVDNVAPFSKMTIDLACGIDGNSDLSKTGKSLWPRVPVLHFAANAGHLLTAIRDIGVSVMSVDYTKPLDEASELLDDSMPLQGNIDPAMLFAPWEVLKRHVLDIVQRASRAPSHVLNLGHGVPPDASCDQLARIVDLAHSMV
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEP10_MOUSE
Sequence: MASCDEIKEHPRSLSMCGHVGFESLPDQLVDRSIEQGFCFNILCVGETGIGKSTLINTLFNTNFEELESSHFCPCVRLRAQTYELQESNVRLKLTIVNTVGFGDQINKEDSYQPIVDYIDDQFEAYLQEEVKIKRALFNYHDSRIHVCLYFIAPTGHSLRTLDLLTMKSLDNKVNIIPLIAKADTISKSELQKFKMKLMNELVINGVQIYQFPTDDDTTSKINGAMNGHLPFAVVGSMDEIKVGNKMVKGRQYPWGIVQVENENHCDFVKLREMLICTNMEDLREQTHMRHYELYRRCKLQEMGFVDMGPENKPLSLQETYEAKRHEFYGERQRKEEQMKQMFVQRVKEKEAILKEAERELQAKFEHLKRIHQEERMKLEEKRRMLEEESVAFAKKKATCELFPNQSFLASGSSIRKDKDRKKADGASAFCDCLTAQESVRLCISSPRKDMD
What is the function of this protein?
Filament-forming cytoskeletal GTPase (By similarity).  May play a role in cytokinesis (Potential).
What are the official names of this protein?
Septin-10.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton.
Protein: OPS3_DROVI
Sequence: MDFNISGIGNVS
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.
What are the official names of this protein?
Opsin Rh3, Inner R7 photoreceptor cells opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ZNT7_CHICK
Sequence: MLPLSIKDDEYKPPRLNLFRKMSGWFRSILADKTSRNLFFFLCLNLSFAFVELLYGVWSNSLGLISDSFHMFFDCTALLAGLAASVISKWRSNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERALEPPDVHHERLLPVSILGFIVNLIGIFVFQHGGHGHSHGSGHEHSHSLFNGGLSHGHSHRGHGHSHEHKHGHTHDHGHSHGLSHGQDYCHDDHCLEGMTGSSKQILQGVFLHIVADTLGSIGVIISAILMQNYGLMIADPICSMLIALLIGVSIVPLLKESIGILMQRTPPSLENALPQCYQRVQQLQGVYSLHDPHFWTLCTDVYIGTLKLLVAPDADGRWILSQTHNIFTQAGVRQLYIQIDVAAM
What is the function of this protein?
Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:15525635, PubMed:15994300, PubMed:16636052).  By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (PubMed:15525635, PubMed:15994300, PubMed:16636052).
What are the official names of this protein?
Zinc transporter 7, Solute carrier family 30 member 7.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Protein: TO402_DROME
Sequence: MGNVMASTADAESSRGRGHLSAGLRLPEAPQYSGGVPPQMVEALKAEAKKPELTNPGTLEELHSRCRDIQANTFEGAKIMVNKGLSNHFQVTHTINMNSAGPSGYRFGATYVGTKQYGPTEAFPVLLGEIDPMGNLNANVIHQLTSRLRCKFASQFQDSKLVGTQLTGDYRGRDYTLTLTMGNPGFFTSSGVFVCQYLQSVTKRLALGSEFAYHYGPNVPGRQVAVLSAVGRYAFGDTVWSCTLGPAGFHLSYYQKASDQLQIGVEVETNIRQQESTATVAYQIDLPKADLVFRGSLDSNWLISGVLEKRLQPLPFSLAISGRMNHQKNSFRLGCGLMIG
What is the function of this protein?
Channel-forming protein essential for import of protein precursors into mitochondria.
What are the official names of this protein?
Mitochondrial import receptor subunit TOM40 homolog 2, Translocase of outer membrane 40 kDa subunit homolog 2.
What is the protein family that this protein belongs to?
Belongs to the Tom40 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: ACSA_RHIME
Sequence: MDVKTYPVLEAAKNRTLLDNATYLEWYRESVADPEKFWGEHGKRIEWFEPYTKVKNTSFEGDVSIKWFEDGLTNVSYNCIDRHLKTHGEKTAIIWEGDNPYLDKKITYNELYDKVCRLANVLKEQGVKKGDRVTIYMPMIPEAAYAMLACARIGAIHSVVFGGFSPEALAGRIVDCESTFVITCDEGVRGGKPVALKENTDTAIDIAARQHVTVSKVLVVRRTGGKVGWAPGRDLWYHQETAAAEPHCPPEKMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYQDGDIYWCTADVGWVTGHSYIVYGPLANAATTLMFEGVPNFPDAGRFWEVVDKHKVNIFYTAPTAIRSLMGAGDDFVKRSSRSSLRLLGTVGEPINPEAWEWYYHVVGDERCPVVDTWWQTETGGILITPLPGATDLKPGSATRPFFGVQPQIVDSDGKVVDGAADGNLCITDSWPGQMRTVYGDHERFIQTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHNLVSEAAVVGYPHPIKGQGIYCYVSLMAGEVGDDELRQALVKHVRSEIGPIATPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGSLGDTSTLADPGVVDDLIANRQNRA
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: GLYA_THEYD
Sequence: MKMKSLREVDAEIYSLILQEKKRETNKILMIASENYASRAVMEAQGSLFTNKYAEGYPGRRYYGGCEYADEVERLAQERAKQLFNVEHVNVQPHSGTQANMAVYFAMLQPGDTIMGMSLTHGGHLSHGSPVNFTGKLYKTVFYGVNKETGYIDMDEVRRLAQEHKPKIIITGASAYPRTIDFKAFSEIAKEVGAYLMADIAHIAGLIATSMHPSPVPYSDFITTTTHKTLRGPRGGVVMCKAQYAKAIDKTVFPGIQGGPLVHVIAAKAVAFKEALSEDFKEYQKKVIKNAKTLAEALKKKGFKLVSDGTDNHLMLVDLTNFNITGKEAEEALDKAGITVNKNTIPFDTKPPTVTSGIRIGTPSVTTRGMGEEEMEKIAEIIERVIKNISNDSVIKDMQKKVQELCKKFPIY
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPAL3_HUMAN
Sequence: MDGSHSAALKLQQLPPTSSSSAVSEASFSYKENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGVFASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYMLVEIILFCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSSLIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPGMQNMHDKGMTVQPELKASFSYGALENNDNISEIYAPATLPVMQEEHGSRSASGVPYRVLEHTKKE
What are the official names of this protein?
NIPA-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the NIPA family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS3_XANC5
Sequence: MGHKVHPTGIRLGIAKDWNSKWYANKAEFASYLAADLKVREMLRKKLAQAGVSKILIERPAKTARVTIHTARPGVVIGKRGEDIEKLRKEVSQLMGVPAHINVTEVRKPELDAQLVAESIAQQLERRIMFRRAMKRSVGNAMRLGALGIKVNVAGRLNGAEIARSEWYREGRVPLHTLRADIDYGFAEASTTYGIIGIKVWIYKGEVFDFSQVGQEKQDDSPRNDRNDRGDRGDRPSRPAREAR
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: TRMB_SHEDO
Sequence: MSDVTTAEFNEEGKYLRKIRSFVLREGRLTKGQAQAIEAHWPTMGLDYTPEAIDLVKIFGREADTVLEIGFGMGGSLVEMAAAAPELNYIGIEVHKPGVGACLGVAGEAKVTNLRVYHHDAMEVLEHSIADGSLSRVQLFFPDPWHKKRHHKRRIVQAEFAELIRRKLKLGGVFHMATDWENYSEHMLEVMNLAPGYKNQSPTGTVVERPDHRPLTKFEARGHRLGHGVWDIMFERIS
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: CN37_MOUSE
Sequence: MNTSFTRKSHTFLPKLFFRKMSSSGAKEKPELQFPFLQDEDTVATLHECKTLFILRGLPGSGKSTLARLILEKYHDGTKMVSADAYKIIPGSRADFSEAYKRLDEDLAGYCRRDIRVLVLDDTNHERERLDQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEPKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTGLDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYGKGKPVPIHGSRKGGAMQICTII
What is the function of this protein?
Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates (By similarity).  May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (PubMed:22393399).
What are the official names of this protein?
2',3'-cyclic-nucleotide 3'-phosphodiesterase, CNP, CNPase.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. CNPase family.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor. Melanosome. Note=Firmly bound to membrane structures of brain white matter.
Protein: TCHP_MOUSE
Sequence: MALPTLPSYWSSRKHMDLRQRQHQQEDQFRQQWEQNSRYFRTWDIHNSKQIEWSSKISYQRSMHAYHCEKMKEEKRKILELRRERLRELLLEEQDLLAAELDELRLSMGLREQRLREQHQDLKSAREEQRKLIAERLLYEHWKKNNPKLRELELDLHKKHVINSWATQKEEKKQQEATEKQENKRLENQYAAARREAEARMRVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQLNRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAELQQLLREEAKEMWEKREAEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELEAQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPKLHGHLRIAWD
What is the function of this protein?
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress.  May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery.  May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity).  Is a negative regulator of ciliogenesis (By similarity).
What are the official names of this protein?
Trichoplein keratin filament-binding protein, Protein TCHP, Mitochondrial protein with oncostatic activity, Mitostatin.
What is the protein family that this protein belongs to?
Belongs to the TCHP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion.
Protein: PSD_CLOPA
Sequence: MIKYYNRKTKNYEIEKIAGEKYLNWTYNSPVGMTILEKFIKKKLFSKIYGLYCNSKISSYKIKKFATDFNINMSHSEKSFNDFKSFNDFFSRKLIKSSRPIADNKNFLISPCDGKIIVYNNINMNNIIQVKGITYKLNDLIQNDSISKTYEKGTCIIARLCPTDYHRFHFLDNGICESTIKIKGNYYSVNPIALNKINNLFCQNKREWSIFNSDNFGKILYVEIGATCVGSIIQTYMPNKKVLKGMEKGYFKFGGSTIVLFLEHNKVIIDEDILTESKLGIETKVLMGERIGTKLN
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type II sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TRPD_BURM9
Sequence: MTITPQEALQRTIEHREIFHDEMLHLMRLIMRGDMSPVMAAAIITGLRVKKETIGEIAAAATVMREFARRVEVEDNANFVDIVGTGGDGSHTFNISTATMFVAAAAGAKVAKHGNRGVSSKSGSADVLEALGVNIDLQPEQVAASIAETGMGFMFAPNHHPAMRNIAPVRRELGVRTIFNILGPLTNPADAPNQLMGVFHPDLVGIQVRVMQRLGAQHVLVVYGKDGMDEVSLGAATLVGELRDGEVREYEIHPEDFGMQMVSNRTLKVESADESRVMLLEALGNKPGVAREIVTLNAGTALYSADVAGSIADGIQLARDAIASGRAREKVDELVRFTQQFKR
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: YM086_YEAST
Sequence: MLLFCYCLLLGTRIGTRIGTRIFIVHPIISPLIAVETAKKKKHIKWRFLDYSLLKNPLYVTVHGSHRSEVERARKRIKYITCTRREFLPRVPISFYQRFFSVFCRNYPSFLL
What are the official names of this protein?
Putative uncharacterized protein YMR086C-A.
Protein: RL1_BURMA
Sequence: MAKISKRRQAFAAKVDRQKLYPIDDALALVKECASAKFDESIDVAVQLGIDAKKSDQVVRGSVVLPAGTGKSVRVAVFAQGEKAEQARAAGAEVVGMEDLAEQIKAGQMDFDIVIASPDTMRIVGTLGQILGPRGLMPNPKVGTVTPDVATAVKNAKAGQVQFRVDKAGIIHATIGRASFEPTALRTNLSALIEALQKAKPATSKGVYLRKIALSSTMGVGVRVDQGSLAAQ
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: FABG_THEMA
Sequence: MRLEGKVCLITGAASGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDPYVLNVTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMKEEDWDAVINVNLKGVFNVTQMVVPYMIKQRNGSIVNVSSVVGIYGNPGQTNYAASKAGVIGMTKTWAKELAGRNIRVNAVAPGFIETPMTEKLPEKARETALSRIPLGRFGKPEEVAQVILFLASDESSYVTGQVIGIDGGLVI
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
What are the official names of this protein?
3-oxoacyl-[acyl-carrier-protein] reductase FabG, 3-ketoacyl-acyl carrier protein reductase, Beta-Ketoacyl-acyl carrier protein reductase, Beta-ketoacyl-ACP reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: TMM95_BOVIN
Sequence: MWTLALGGIFLAAVEACVFCRFPDRELSGRLARLCSQMEVQWKDCEVSWTFSAFALDDASLNKITEKTHRVLRVMEIKGSLYSLPSYWQWLRKTKLREYNREALCPPSCRGSTILYNCSTCQGFEVYCWPRKRCFPGSHDLWEARILLLFVCGTALLLGVPSLAVE
What is the function of this protein?
Sperm protein required for fusion of sperm with the egg membrane during fertilization.
What are the official names of this protein?
Sperm-egg fusion protein TMEM95, Transmembrane protein 95.
What is the protein family that this protein belongs to?
Belongs to the TMEM95 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Note=Following the acrosome reaction, relocalizes to the equatorial segment.
Protein: RL24_RAT
Sequence: MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQINWTVLYRRKHKKGQSEEIQKKRTRRAVKFQRAITGASLADIMAKRNQKPEVRKAQREQAIRAAKEAKKAKQASKKTAMAAAKAPTKAAPKQKIVKPVKVSAPRVGGKR
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L24, L30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSM6_PHANO
Sequence: MSTNGESPAPEGAGDSRDPSGFLSEIIGAPVTVKLNSGIVYKGDLQSVDGYMNIALERCKEVAEGRVIRNWGDAFVRGNNVTYISADNA
What is the function of this protein?
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates.  Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.  Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs.  LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6. U5 tri-snRNP, and free U6 snRNP).  It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes.  LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm6.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.