PharMolix/UniProtQA huggingface dataset:
Protein: ANDK_EMEVA
Sequence: MMPTVTAVSAILPLAILFVFSRALWKLWYLSDIPGPFWCKLTNIPRLCWVRTGRAHDIHYELHKEYGKLVRIGPSMISISDPAALSTVYPTRMGVPKSDFYKTQRPYVPGTGALPVVFNTQNEELHKELRGPVSSLYAMSNVMKLEPLMDETLQVLFDQIDARFVSGTKAFDLSNWLQFFAFEVMGTISFSKKYGFLEAGRDFNGLLSGIWGFMKSAAPMGQMPWLDDVLYKNALAAKLRGTTGMPVLRIVNKYITERITGHAKASSDHADMLSQFLDIQASNEKVPTWAPKAWTFSNVIAGSDSSANSMTTVMYNLMTHPETMARLYQELSEAKQQAGNVTAHILPWTSIRDLPYLDACVMEAFRIHPAFCLHLERLVPETGMEICGKQIPPGAIVGMSPWVINRHKPTFGEDVHQWRPERWLGHSETRLQELKNTILTFGYGRRVCLGKNIAIMEIKKLISSLVLNYEWTVIDPSEYRVENKWFFKQSGFDVTVKHRSSVRHTPRATNMTKVPPTLAIPASSSTVEVRVINTRTIMRTDHSLLWKSPVEGFKGLDLPIYAFLISNGNRHIIFDLGLRQDYENLPPRIAGLLKNAPYIVTEANVSEILDSDDTGLDIKGRDIEAVIWSHHHYDHTGDPSTFPPSTKLVVGPGVLSLTGGGYPKNPNTTVLETDLSGRKIQEISFDAQADSSVKVGPFDGVDYFGDGSFYLLNAPGHSVGHMCGLARVTTAPDTFIFMAADGCHHPGAIRPSEYMALPRDIPKSLVRKLRTAEADSGGKAQDGDTKPLLPFLPALFPDYTQAMETVEKIKQLDACDNVFVILPHDGSLLGAIDFFPRPINDWKKKGLKESTRWKFCQEMEEALSG
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of anditomin, a fungal meroterpenoid (PubMed:25216349).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase andM (PubMed:25216349).  DMOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHDMP) by the cytochrome P450 monooxygenase andK, which is further prenylated by the prenyltransferase andD to yield farnesyl-DHDMP (PubMed:25216349).  Further epoxidation by the FAD-dependent monooxygenase andE leads to epoxyfarnesyl-DHDMP (PubMed:25216349).  The next step involves the terpene cyclase andB that converts epoxyfarnesyl-DHDMP into preandiloid A through opening of the epoxide ring followed by the cyclization of the farnesyl moiety (PubMed:25216349).  Preandiloid A is in turn oxidized at the C-3 hydroxyl group to yield preandiloid B by the dehydrogenase andC (PubMed:25216349).  The dioxygenase andA is solely responsible for the dehydrogenation of preandiloid B leading to the enone preandiloid C, as well as for the intriguing structural rearrangement to generate the bicyclo[2. 2. 2]octane core, transforming preandiloid C into andiconin (PubMed:25216349).  FAD-binding monooxygenase andJ then produces andilesin D which is reduced by dehydrogenase andI to yield andilesin A (PubMed:25216349).  Action of acetyltransferase andG followed by a spontaneous acetate elimination leads then to andilesin B, which is in turn substrate of the short chain dehydrogenase andH to yield andilesin C (PubMed:25216349).  Finally, the dioxygenase andF catalyzes the transformation of andilesin C to anditomin (PubMed:25216349).
What are the official names of this protein?
Cytochrome P450 monooxygenase andK, Anditomin synthesis protein K.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: PURA_DROER
Sequence: MSASATNGTHYEQLHQGRTKMYKSKVDVVLGAQWGDEGKGKVVDMLASDVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCVSVIGNGVVIHLPSLFDEVLKNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDFNLFSEKFKSIVATHVRLFPSINVDVEAELARYKDYADKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNDIGDLLQTRGFEIGVTTKRKRRCGWLDIPLLKYTSLVNGYTCICVTKLDILDTLPEIKVAVAYKKPSGEKLDHFPGTIAELGNIEVEYAVLPGWQTSTEDVRNFKELPENAQSYVRFLESELSVPVRWVGVGKGRESIINVH
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_PROM9
Sequence: MAIISSNIGDNDFSLRKKELRLVDSKIIPEEKRKNNLNLARPITFQEFIGQEKLKSSLRIAIDASIYRKEPLEHTLLYGQPGLGKTTLAFLIAKEMNTKCRIATAPAIERPRDIVGLLLGLKEGEVLFIDEIHRLNRLTEELLYSAMEDFRLDLTMGANRGARCRTINLPRFTLVGATTKLASISAPLRDRFGISQKIEFYTCDELKQIIDNFSRLISFNVDDEASSHLAKISRGTPRIALRLLRRVRDYAQVVKKTNVISVNLIKKALNSYQIDEKGLDYVDRQYLSFLNQNKNIPTGLDSIAAGLGDDSSMLEFVVEPYLIQIGFLTRTPRGRLLTALGKKYIDSKNDNF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: AGRIN_CHICK
Sequence: MGGSGAAATLALGLALGLALGGWANCPERELQRREEEANVVLTGTVEEIMNVDPVHHTYSCKVRVWRYLKGKDIVTHEILLDGGNKVVIGGFGDPLICDNQVSTGDTRIFFVNPAPQYMWPAHRNELMLNSSLMRITLRNLEEVEHCVEEHRKLLADKPNSYFTQTPPTPRDACRGMLCGFGAVCERSPTDPSQASCVCKKTACPVVVAPVCGSDYSTYSNECELEKAQCNQQRRIKVISKGPCGSKDPCAEVTCSFGSTCVRSADGQTAGCVCPASCSGVAESIVCGSDGKDYRSECDLNKHACDKQENVFKKFDGACDPCKGILNDMNRVCRVNPRTRRVELLSRPENCPSKREPVCGDDGVTYASECVMGRTGAIRGLEIQKVRSGQCQHQDKCKDECKFNAVCLKRWHARCSCDRITCDGTYRPVCARDSRTYSNDCERQKAECHQKAAIPVKHSGPCDLGTPSPCLSVECTFGATCVVKNREPVCECQQVCQGRYDPVCGSDNRTYGNPCELNAMACVLKREIRVKHKGPCDRCGKCQFGAICEAETGRCVCPTECVPSSQPVCGTDGNTYGSECELHVRACTQQKNILVAAQGDCKSCGTTVCSFGSTCVGGQCVCPRCEQQPLAQVCGTDGLTYDNRCELRAASCQQQKSIEVAKMGPCEDECGSGGSGSGDGSECEQDRCRHYGGWWDEDAEDDRCVCDFTCLAVPRSPVCGSDDVTYANECELKKTRCEKRQNLYVTSQGACRALTTTPPPLPVVHCSQTIYGCCPDNMTLALGVGAAGCPSTCQCNPYGSYGGTCDPATGQCSCKPGVGGLKCDRCEPGFWNFRGIVTDSKSGCTPCNCDPVGSVRDDCEQMTGLCSCKTGITGMKCNQCPNGSKMGMAGCEKDPSAPKSCEEMSCEFGATCVEVNGFAHCECPSPLCSEANMTKVCGSDGVTYGDQCQLKTIACRQGQLITVKHVGQCHESITHTSHTMPPTPLPTLPLDKLIVPPPLQLTTQAPEPTELATTSLLMEASPTTRSHPTTRRVTTTRPVTTPWMTHGVLKTTVRPLSTSPVVLATTQPPYAESGSAEGSGDQEMSISGDQESSGAGSAGEEEVEESQVTPTPAIERATCYNTPLGCCSDGKTAAADAEGSNCPATKVFQGVLILEEVEGQELFYTPEMADPKSELFGETARSIESALDELFRNSDVKNDFKSIRVRDLGQSSAVRVIVESHFDPATSYTAADVQAASLKQIRASKKRTILVKKPQQEHVKFMDFDWIPRIFTTTITTTTATTMAPATTRRHTTASAATTAHILRQDTVGHPSAKLAAPASTRRPTSTLPTTARRKPTRQPPSTTKKPSRPCDSHPCLHGGTCEDDGREFTCRCPAGKGGAVCEKPIRYFIPSFGGKSYLAFKMMKAYHTVRIAMEFRATELSGLLLYNGQNRGKDFISLALVGGFVELRFNTGSGTGVITSKVRVEPGKWHQLVVNRNRRSGMLAVDGEHVSGESPTGTDGLNLDTDLFVGGAPEDQMAVVAERTAATVGLKGSIRLLDVNNQMYDLREKGSDVLYGSGVGECGNDPCHPNPCHHGASCHVKEAEMFHCECLHSYTGPTCADERNPCDPTPCHISATCLVLPEGGAMCACPMGREGEFCERVTEQDHTMPFLPEFNGFSYLELNGLQTLFLTCRQMSMEVVFLAKSPSGMIFYNGQKTDGKGDFVSLALHDGYLEYRYDLGKGAAVLRSKEPVPLNTWISVLLERSGRKGVMRINNGERVMGESPKSRKVPHAFLNLKEPFYVGGAPDFSKLARAAAISTSFYGAVQRISIKGVPLLKEQHIRSAVEISTFRAHPCTQKPNPCQNGGTCSPRLESYECACQRGFSGAHCEKVIIEKAAGDAEAIAFDGRTYMEYHNAVTKSHLSNEIPAPDALDYPAEPSEKALQSNHFELSIKTEATQGLILWSGKGLERSDYIALAIVDGFVQMMYDLGSKPVVLRSTVPINTNHWTHIKAYRVQREGSLQVGNEAPITGSSPLGATQLDTDGALWLGGMERLSVAHKLPKAYSTGFIGCIRDVIVDRQELHLVEDALNNPTILHCSAK
What is the function of this protein?
This released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect.  All 'B' splice variants of this fragment also show an increase in the number of filopodia.
What are the official names of this protein?
Agrin.
What are the subcellular locations of this protein?
[Isoform 1]: Secreted, extracellular space, extracellular matrix. Note=Synaptic basal lamina at the neuromuscular junction. SUBCELLULAR LOCATION: [Isoform 9]: Synapse. Cell membrane; Single-pass type II membrane protein.
Protein: RS20_PSEPF
Sequence: MANSPSAKKRAKQAEKRRSHNASLRSMVRTYIKNVVKAIDAKDAEKAQAAYVLAVPVIDRMADKGIIHKNKAARHKSRLNGHVKALKAAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: MRE11_NEUCR
Sequence: MPRSEADTIRILVSTDNHVGYAERHPVRKDDSWRTFDEIMQIAKKQDVDMVLLGGDLFHENKPSRKSMYQVMRSLRKHCLGMKPCELEFLSDAAEVFEGAFPFVNYEDPDINVAIPVFSIHGNHDDPSGDGHYCSLDLLQAAGLVNYFGRVPEADNIHVKPILLQKGRTKMALYGLSNVRDERMHRTFRDNKVRFYRPNQQKNDWFNLLALHQNHYAHTRTSYVAENMLPDFMDLVIWGHEHECLIDPVRNPETGFHVMQPGSSVATSLVPGEAVPKHVAILNITGRKFEVDKIPLKTVRPFVTREIVLASDKRFKGLDKQNNRHEITKRLMVIVNEMIEEANAEWRAVHAEDDDMDEDMEPPLPLVRLKVDYTAPDGARYEVENPHRFSNRFTGKVANHNDVVRFHCNTKGKKNVATAPGVREDIAEILESADTIKVDNLVQEFFAQQSLKILPQAPFSDAVNQFVSKDDKHAVEMFVIESLSTQVKELLQLDDDKIVDLDAHIQDFRQVMEKSFDAGQHKQAQRTKRFKRKPDGWDSDLDGHWINQPQALEDIPAEVEPKGNDRPTKRVPTSGVTFSDEDEDMDMDNQPVPIRAAPKRGAAAKTTAAAKKAAPGKKAAPAKKAAPAKKAAPAKKAPARGRKKKTPFVDSDEEEEEDYPEDDDEEEEEADEEEEDVIMEDDEEDPPAPPPKPKATSRVASTRASARATPVRATPARATQARLRLRRPPKPGLLARRLG
What is the function of this protein?
Involved in DNA double-strand break repair (DSBR).  Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity.  Also involved in meiotic DSB processing (By similarity).
What are the official names of this protein?
Double-strand break repair protein mus-23, Recombinational repair protein mus-23.
What is the protein family that this protein belongs to?
Belongs to the MRE11/RAD32 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SPEF2_HUMAN
Sequence: MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDILIDLVTLNLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPWPIPLEEELLETLQKFKAVDKEQLGTITFEQYMQAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYEKDPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAEKTSSTDAGPAEEFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLKVFKGGSEAQDSNRFASHLKIENIYAEGFIKTFQDLGAKNLEPIEVAVLLKHPFIQDLISNYSDYKFPDIKIILQRSEHVQGSDGERSPSRHTEEKK
What is the function of this protein?
Required for correct axoneme development in spermatozoa.  Important for normal development of the manchette and sperm head morphology.  Essential for male fertility.  Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis (PubMed:31278745, PubMed:31151990, PubMed:31048344).  Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (By similarity).
What are the official names of this protein?
Sperm flagellar protein 2, Protein KPL2.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Cytoplasm. Golgi apparatus. Note=Shows dynamic localization in developing spermatozoa. Localizes to the manchette in step 10-12 elongating spermatids. Detected in the basal body and neck area of step 13-14 spermatids. Localizes to the midpiece of the sperm tail in step 15-16 spermatids. During the epididymal transport of spermatozoa, expression in the sperm tail reduces and becomes concentrated at the distal part of the midpiece. Detected in the Golgi apparatus of late spermatocytes and round spermatids. Detected in the cytoplasm of Sertoli cells.
Protein: MUTS2_STRZP
Sequence: MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLASRELQNFYANLENVSLEELALWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHDSESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKPVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFIDQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: YCBJ_BACSU
Sequence: MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAKDDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGTPAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFRQMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRVTGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAAYPVEIAKLALQTQQEEHINMALEALGVTSD
What are the official names of this protein?
Uncharacterized protein YcbJ.
What is the protein family that this protein belongs to?
Belongs to the aminoglycoside phosphotransferase family.
Protein: PUR5_YERPA
Sequence: MTNKTSLSYKDAGVDIDAGNDLVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPILVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMPGMYHGDDYDVAGFCVGVVEKSEIIDGSKVTPGDVLVALGASGPHSNGYSLVRKILDVSNTNPEQTSLEGKSLADHLLEPTKIYVKSILSLIEQLDIHAIAHLTGGGFWENIPRVLPQGMQAVIDEASWQWPAVFSWLQQAGNVSRHEMYRTFNCGVGMVVALPAELADKAVELLTASGEKAWKIGVIAAATEGAEQVIINP
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_ENT38
Sequence: MSDVSKASLPKAIFLMGPTASGKTALAIELRKVLPVELISVDSALIYQGMDVGTAKPNAEELHAAPHRLLDILDPAQAYSAADFRRDALAEMAEITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRAKIEQQAAEQGWSALHKQLEEVDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGEALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFEAEVRALFARGDLHTDMPSIRCVGYRQIWSYIEGEISYDEMVYRGVCATRQLAKRQITWLRGWEGIHWLDSEKPEQSYNEVLQVVGAIAD
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: BIOF_MYXXD
Sequence: MSDEAVAAAWAREDLEALSERGLRRYLEPLDSPQGPVVRVGGETLVNFSSNDYLGLAASPTVRAAALAAVERYGVGTGASRLVVGDTAAHHRLETRLAAFERAEAVRLFNSGYAANTGIIPALVGSEDAVFSDALNHASLVDGCRLSRARVCVYPHADVEALTRALAETPARRKLVVTDTVFSMDGDVAPLRDIVAACRAHGAALMVDEAHATGVLGARGAGLCDELGLESEVDLRMGTLSKALGVMGAYVATSREVADLLVSRARPFVFSTALPAHLCAAAEAAVDAVEGDPDLRERLWRNIRRFADGLRGLGVRAEPRSAVFPLILGEPERALDAARRLREAGVLVKAIRPPTVPEGTSRLRFCLSASHTVGHVDLALEALRSVGVRRG
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: THN1_VISAL
Sequence: KSCCPBTTGRBIYBTCRFGGGSRZVCARISGCKIISASTCPSYPBK
What is the function of this protein?
Thionins are small plant proteins which are toxic to animal cells.  They seem to exert their toxic effect at the level of the cell membrane.  Their precise function is not known.
What are the official names of this protein?
Viscotoxin-1-PS.
What is the protein family that this protein belongs to?
Belongs to the plant thionin (TC 1.C.44) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PIMT_DESVM
Sequence: MLDMKRNRERMVKQQLETRGITDPAVLAAMRSVPRHLFVQEALRAQAYEDHPLPIGYGQTISQPFIVALMSQIIEPQPGLRVLEIGTGSGYQAAVLAEMGLDVYTVERIRELHAAARDLLRTLKYRKVRLKLDDGTLGWPEAAPYDRILVTAGGPEVPLPLIEQLADPGIMVIPVGASKRMQELVVVRKQGGRVVRESKGGVAFVDLVGTHGWRG
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_MYCMM
Sequence: MTQDGTWSDESDWELDDADLADLAEAAPAPVLAIVGRPNVGKSTLVNRILGRREAVVQDIPGVTRDRVSYDALWNGRRFVVQDTGGWEPDAKGLQQLVAEQASVAMRTADAVVLVVDATVGATTADEAAARILLRSGKPVFLAANKVDSDKAEADAATLWSMGLGEPHAISAMHGRGVADLLDTVLKKLPEVAESVSAGGGPRRVALVGKPNVGKSSLLNKLAGDERSVVHDVAGTTVDPVDSLIELGGKVWRFVDTAGLRRKVGQASGHEFYASVRTRGAIDAAEVVVLLIDASQPLTEQDLRVLSMVIEAGRAVVLAYNKWDLVDEDRRDLLDREIDRELVQIRWAQRVNISAKTGRAVQKLVPAMETALASWDTRIPTGPLNSWIKEVVAATPPPVRGGKQPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFEGSPIRINVRVREKRGAKRPGRR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: GPDA_ACICJ
Sequence: MTAHPEFAVIGAGAWGTALASLYAAQGRRVALVARDSTKAAALATTRTTPRLPGLRLPDSLAVTARPPEAPVTLLAVPFQHLRETLGRLPQGNGTLVLCAKGVERESGALGPEIAAEMEPRRPCAVLTGPNFAHEIAIGLPAAAVLAMTDDGARRDLVQHLATPRLRVYGSADPIGAALGGAAKNVIAIAAGAVIGAGLGENARAALITRGLAEIARLTEALGGAAETISGLAGLGDLILTATGSASRNYRAGLAFGQGKRPDTEAGVIEGIATAPALLARARATGCEMPVTEAVTDLLAGRITLEASMNRLLRRALRDER
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_RHOOB
Sequence: MKSALHESRADTAEGTSSASSAWKSVRALPARTLIFFIELYRTYVSPLRMPTCRFMPTCSEYAVESLRTHGTIKGLLLTVVRLAKCAPWHPGGWDPVPARHDRHAGSRRCCPANVDEQRST
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: 4CL1_DICDI
Sequence: MIIKVKGQTYFTSKYPNIIIPEKPVPQLILKHIRSKPDQVLLVDGLTFKEYSSHFVADTIEKVACGLNKLNIKKGDVLGVILPNLPEYVPIFHGTLLMGGITSLVNPDYTIEELSHTLATVSPRYLAVTLAVYEKIKNDLKRVFPSVEKVILVDIAGQTLKEIDQLTLSSDGIVMSFNQLINNNGKDYPIVRIDPKKDTAIIPFSSGTTGLFKGVCLSHHNIVSNTYQTQTIETSTYKKNDTVMGILPFFHIYGLMLFLMLMVKQGHRVVVLPKFEPVRFLELIQKYKVAISFIVPPVAIMFAKSPIVDKFDLSSLRTLFSGAAPLSSEVEDLIKERFKGRLVIKQGYGATELSPACFVIPSGLVKSGSAGILLPNQLAKIISPETGENLGMGEKGEICIKGPNVMLGYYNNEKATNEVIDKDGFLKTGDIGYVDEDGYYFIVDRSKELIKCKGFQVPPAELEALLLSHPKVADACVVGLSKGDMGEVPRGFVVIKQNESLTEKELLDWAHPKIANYKHFRGGIFFIPAIPKSATGKLLRKNLKDFNPPKL
What is the function of this protein?
Carboxylate--CoA ligase that may use 4-coumarate as substrate.  Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.
What are the official names of this protein?
Probable 4-coumarate--CoA ligase 1, 4CL 1, 4-coumaroyl-CoA synthase 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: RUVB_STAHJ
Sequence: MDDRMVDQALHSEETSFELSLRPTMLKQYIGQSSIKNNLEVFIKAAKLREEPLDHVLLFGPPGLGKTTLSNIIANEMNVNIRTVSGPSLDRPGDLAAILSGLQPGDVLFIDEIHRLSSTVEEVLYSAMEDFFIDIIIGKGDEARSIRIDLPPFTLVGATTRAGSLTGPLRDRFGVHLRLEYYNENDLKEIIIRTAEVLNTKIDDESATELAKRSRGTPRVANRLLKRVRDFQQVNEDEQIYIETTKQALQLLQVDAEGLDYIDHKMMRCIINQYDGGPVGLDTIAVSIGEERITIEDVYEPFLIQKGFIERTPRGRKATAFAYEHFKNFNK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.