PharMolix/UniProtQA huggingface dataset:
Protein: MDM10_YARLI
Sequence: MLTFMEHILYSFYDASGWHRDNLYALLTHSSQNLIDFRVPEGVAMNVSALSTPNSASSYTLTNLGHIQGSVAYLSTSLSLPRPHSGTLDLHTVVPGYHKLDPINSQDRIYDTIWQGGKPIHRQDSLLFGRLALPTNTLEAMYVRRFNPTTQLLVTCVSGAHLKSGGALTLYWQKDCRQYAHELLYSTNEALLGARGLYNFGVDMSKPHIASRLSVGGEFYYGVLNKSPGMSTALRYVTQSAYTGSPLTMTLTCNPIMGEFSSTYSLRTGPSSSFSTRYDFNMYSYLSNLSMGAEVWKSRDSVFKLSSSLQDKTARVLWGGRYKDILVNTGVAFDYGGRVPDVTAIGVEFQYAC
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange.  MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex).  Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins.  Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins.  May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway.  Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 10, Mitochondrial inheritance component MDM10.
What is the protein family that this protein belongs to?
Belongs to the MDM10 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: ASTE_SHIDS
Sequence: MDNFLALTLTSKKPVITEREINGVRWRWLXLELTPLTPPQGALVISAGIHGNETAPVEMLDALLGAISHGEIPLRWRLLVILGNPPALKQGKRYCHSDMNRMFGGRWQLFAESGETCRARELEQCLEDFYDQGKESVRWHLDLHTAIRASLHPQFGVLPQRDIPWDEKFLTWLGAAGLEALVFHQEPGGTFTHFSARHFGALACTLELGKALPFGQNDLRQFAVTASAIAALLSGESVGIVRTPPLRYRVVSQITRHSPSFEMHMASDTLNFMPFKKGTLLAQDGEERFTVTHDVEYVLFPNPLVALGLRAGLMLEKIS
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: RR2_EUCGG
Sequence: MTRRYWNINLEEMMEAGVHFGHGTRKWNPRMAPYISAKRKGIHITNLTKTARFLSEACDLVFDAASRGKQFLIVGTKNKAADSVARAAIRARCHYVNKKWLGGMLTNWSTTETRLHKFRDLRTEQKAGRLNRLPKRDAAMLKRQLSHLQTYLGGIKYMTGLPDIVIIVDQQEEYTALRECITLGIPTICLIDTNCDPDLADISIPANDDAIASIRLILNKLVFAICEGRSSYIRNP
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NU4LM_TETNG
Sequence: MTPIQFTFSSAFLLGLSGLAFHRTHLLSALLCLEGMMLSLFIALSLWSLQLSSISFSSAPMLLLAFSACEASVGLALMVATARTHGSDHLQGLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: FABZ_GRABC
Sequence: MDQSVPSENQPETGEGRTIIDIAGIMKMIPHRYPFLLVDRVIDIVRGERGIGIKNVTASESHFAGHFPNHPVMPGVLIIESMAQTAAVLVVDALGTDAEGRVVYFMSIEGAKFRRPVVPGDQLRIECERLQHRGNVWKFRGTARVDGQIVAEASFAAMILRPSPAQQAEA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBF4A_MOUSE
Sequence: MNLETMRIHSKAPLPGGIQDRNEKNRPSLKSLKADNRLEKSKYKPLWGKIFYLDLPSITICEKLQKDIKELGGRVEEFLSKDISYFVSNKKEAKYAQTLGRVSPVPSPESAYTAETTSPHPSHDGSSFKSQDRVCLSRGKLLAEKAVKDHDFIPANSILSNALSWGVKILHIDDIRYYIEQKKKALSALKKSSASGKDAGKKAGPGIQKTRTGRLKKPFLKVEDVNRCYRPFYLQLPSLPCINYFLQKPCSPFDIEKSSSVQKQAQPKLRINMDGDKCGTPVQLQLKEKRKKGYCECCLQKYEDLETHLLSEKHRNFAQSNQYQVVDDIVSQLVFDFVEYGRDTPQKKRIRYSVGSLSSVSANVLKNTAPKEKPLLEPNFQKDVGESSGHLLKPNSQYEETQKPEEKHGFASEPTTYSSAGLKGCDRKPVSMFNASEPDPEQEYAQLPLRDSTPEHQVTEGRNDGEQRVDPAPGVSQSCGQVSHLSTESNLPQPQLAADITQLSAKDLQEKGFHVVIGHASDLVALNTSKEQLTMKARTPPCSPQEPHECDTENMENLPCGKIQRKVRMLLGQQKANAEPSAELDKKRTEYLPAHEDRTCGSPVQSLLDLFQTSEEKSEFLGFTGYTENSGICDVLDIWEEENSSTLLSTFFSSPSTSAFVGF
What is the function of this protein?
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role DNA in replication and cell proliferation.  Required for progression of S phase.  The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
What are the official names of this protein?
Protein DBF4 homolog A, MuDBF4.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH60_DESVV
Sequence: MASKEILFDTKAREKLSRGVDKLANAVKVTLGPKGRNVVIEKSFGSPVITKDGVSVAKEIELEDKFENMGAQMVKEVASKTSDIAGDGTTTATILAQAIYREGVKLVAAGRNPMAIKRGVDKAVESLVRELGNLAKPTRDQKEIAQVGTISANSDSTIGNIIAEAMSKVGKEGVITVEEAKGLETTLEVVEGMQFDRGYLSPYFVTDPEKMVCELDEPFILCNEKKISTMKDMLPVLEQVAKMQRPLVIIAEDVDGEALATLVVNKLRGALQVVAIKAPGFGERRKAMLQDIAVLTGGQVVSEDMGIKLENISVADLGTAKRVVIDKENTTIVDGAGKGDDIKARVKQIRAQIEETTSDYDREKLQERLAKLVGGVAVIHVGAATETEMKEKKDRVEDALNATRAAVEEGIVPGGGTALVRVAKVLDDIKPADDDETAGVNIIRRAIEEPLRQIASNAGFEGSIVVERVREGKDGFGFNAATGEYEDLIGVGVIDPKKVTRIALQNAASVASLLLTTECAIAEKPEPKKDMPMPGGMGGMGGMGGMY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK2_PORPU
Sequence: MAIRLYRAYTPGTRNRTVSTFSEITTDKPEKSLINKHHFCKGRNNRGVITCRHKGGGHKQRYRLIDFKRNRHNIIAKVASIEYDPNRNARIALLHYLDGEKRYILHPRSLSVGAIVVSGPMAPIEVGNALPLSTIPLGTAVHNIELRPYCGGQIVRSAGTYAQIVAKEGNFVTVKLPSSEVRMIRKECYATIGQVGNIDASNITLGKAGRSRWLGKRPTVRGVVMNPVDHPHGGGGEGKSPIGRSRPVTPWGKPALGVKTRNPNKYSNPYVLLVVNKVYLTYNLILKYNVEINT
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MMR_STRCO
Sequence: MTTVRTGGAQTAEVPAGGRRDVPSGVKITALATGFVMATLDVTVVNVAGATIQESLDTTLTQLTWIVDGYVLTFASLLMLAGGLANRIGAKTVYLWGMGVFFLASLACALAPTAETLIAARLVQGAGAALFMPSSLSLLVFSFPEKRQRTRMLGLWSAIVATSSGLGPTVGGLMVSAFGWESIFLLNLPIGAIGMAMTYRYIAATESRATRLAVPGHLLWIVALAAVSFALIEGPQLGWTAGPVLTAYAVAVTAAALLALREHRVTNPVMPWQLFRGPGFTGANLVGFLFNFALFGSTFMLGLYFQHARGATPFQAGLELLPMTIFFPVANIVYARISARFSNGTLLTAFLLLAGAASLSMVTITASTPYWVVAVAVGVANIGAGIISPGMTAALVDAAGPENANVAGSVLNANRQIGSLVGIAAMGVVLHSTSDWDHGAAISFLAVGLAYLLGGLSAWRLIARPERRSAVTAAT
What is the function of this protein?
Resistance to the epoxide antibiotic methylenomycin A; probably by mediating its efflux.
What are the official names of this protein?
Methylenomycin A resistance protein, MMR peptide.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLMN_HAEDU
Sequence: MSQQNIPFTNNVQTADFSVQHSKSEKVNLMNMTRQEMREFLANLGEKPFRADQLMKWIYHFGEDEFDNMSNINKVLREKLKKVAEIKAPAIAIEQRSSDGTIKWAMQVGNQQIETVYIPEGDRATLCVSSQVGCALECKFCSTAQQGFNRNLTVSEIIGQVWRASKIIGNFGITGVRPITNVVMMGMGEPLLNMNNVIPAMQIMLDDFAYGLSKRRVTLSTAGVVPALDLMREKIDVALAISLHAPNNELRNEIMPINKKYNIKMLMDSVAKYLAVSNANHGKVTIEYVLLDHVNDGTEHAHQLAEVLKNTPCKINLIPWNPFPEAPYGKSSNSRVDRFQKTLMEYGFTVIVRKTRGDDIDAACGQLAGEVIDRTKRTLEKRKFGKSIMVNNH
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOA_ECOUT
Sequence: MSMSTSTEVIAHHWAFAIFLIVAIGLCCLMLVGGWFLGGRARARSKNVPFESGIDSVGSARLRLSAKFYLVAMFFVIFDVEALYLFAWSTSIRESGWVGFVEAAIFIFVLLAGLVYLVRIGALDWTPARSRRERMNPETNSIANRQR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SCAB1_ARATH
Sequence: MTRVTRDFRDSLQRDGVPAVSADVKFASSRFPNYRIGANDQIFDVKDDPKVMSMKEVVARETAQLMDQQKRLSVRDLAHKFEKGLAAAAKLSEEAKLKEATSLEKHVLLKKLRDALESLRGRVAGRNKDDVEEAIAMVEALAVQLTQREGELFIEKAEVKKLASFLKQASEDAKKLVDEERAFARAEIESARAAVQRVEEALREHEQMSRASGKQDMEDLMKEVQEARRIKMLHQPSRVMDMEYELRALRNQLAEKSKHFLQLQKKLAMCRKSEENISLVYEIDGTEALGSCLRVRPCSNDAPDLSKCTIQWYRSSSDGSKKELISGATKSVYAPEPFDVGRVLHADIIYDGHSLSLSTVGKIDPAAGLGSYVEALVRKHDVDFNVVVTQMSGEDHTSESIHLFHVGKMRIKLCKGKTVIAKEYYSSAMQLCGVRGGGNAAAQALYWQAKKGVSFVIAFESERERNAAIMLARRFACDCNVTLAGPEDRTETGQSP
What is the function of this protein?
Plant-specific actin binding protein that bundles and stabilizes microfilaments (MFs).  Has no nucleation or capping activity.  Regulates MF reorganization during stomatal closure.  The binding to F-actin is insensitive to Ca(2+) and pH.  Binds weakly to inositol phosphates (PubMed:22356912).
What are the official names of this protein?
Stomatal closure-related actin-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the SCAB family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MNME_BORDL
Sequence: MSRLFQKEDDIVALATPFFSSALCVIRSSGVSAIEKFSKMFSDPSKLLEASGHTIHYGYILDNETKEKLDEVVVCLYRAPKSFTGQDSIEVMAHGSLIGIRRIIDFFLKVGFRMAEPGEFTLRSFLAGKLDLTKAEAINELISAKTRQVHALAVNKLSGSLFDKIDLIKKDILNFLSAISVYLDYETDDNEVVIPVDIILKSKSELERLIDSYDTARKLENGVTLVLAGSVNVGKSSLFNLLLKEDRAIVSSYAGTTRDYIQASFEFDGILFNVFDTAGLRETSDFVEQLGIVRSNSLIKEASLIFYVVDLSGKLTDDDLKFIDAYKEDSRVLFVLNKVDLEQNNQTVEFFNSNNVVSLNTVKISTKTLFGINSLYDRIRSLIAVDYMKTSDYDVVISSTRQAELLKRAYALIIELLSKIEQNISYDMLAFDVYEVVNVLGEITGEVTSDDVLDNMFKNFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GYRB_ARCFU
Sequence: MSPDQTAVEYTAKDIEVLDDLEAVRKRPGMYIGGVGVRGLHHLLWEVVDNAVDEALAGYCDTIKVSLHKDGSASVEDNGRGIPTEMHELGKSALEIVMTKLHAGGKFSKKVYRVSGGLHGVGVSVVNALSEWLEVWVKRNGKIYYQKYQRGSRSPEAGHRTEVLGETKEHGTTVRFKPDREIFETTEFKYEIVAQRLKELAYLNRGLKIILFDEREGKEETFHFEDGIIGLVRSLNRNRKPLHEPIYIETTKDGVSVEVAIQFTDSDVENIQAFANNINTSEGGSHVVGFRAGLTRAVNEYGKKHLKKFEPVTGVDIREGLTAVISVKVPEPQFEGQTKTKLTNSDVKTVVESAVYSGVLRWLEENPAQAETLLNKFILNKKAREAAKRAKELVKRKNELITTLPGKLADCSSKNPEERELFIVEGESAGGSAKQARDRRFQAILPIKGKIINVEKAGMARVLKNDEIKAIISAIGAGIGKDFDITKARYRRIIIMTDADVDGAHIRTLLLTFFYRYMRPLIESGYLYIAQPPLYQIKKGKKSYYAYSDEELKRTLEQVGGGEVQRYKGLGEMNPQQLWETTMNPENRILIQVTLEDAKRADELFSILMGEDVESRRNFIMAHSKEVKNLDI
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KATG_SHIBS
Sequence: MSTSDDIHNTTATGKCPFHQGGHDQSAGAGTTTRDWWPNQLRVDLLNQHSNRSNPLGEDFDYRKEFSKLDYYGLKKDLKALLTESQPWWPADWGSYAGLFIRMAWHGAGTYRSIDGRGGAGRGQQRFAPLNSWPDNVSLDKARRLLWPIKQKYGQKISWADLFILAGNVALENSGFRTFGFGAGREDVWEPDLDVNWGDEKAWLTHRHPEALAKAPLGATEMGLIYVNPEGPDHSGEPLSAAAAIRATFGNMGMNDEETVALIAGGHTLGKTHGAGPTSNVGPDPEAAPIEEQGLGWASTYGSGVGADAITSGLEVVWTQTPTQWSNYFFENLFKYEWVQTRSPAGAIQFEAVDAPEIIPDPFDPSKKRKPTMLVTDLTLRFDPEFEKISRRFLNDPQAFNEAFARAWFKLTHRDMGPKSRYIGPEVPKEDLIWQDPLPQPIYNPTEQDIIDLKFAIADSGLSVSELVSVAWASASTFRGGDKRGGANGARLALMPQRDWDVNAAAVRALPVLEKIQKESGKASLADIIVLAGVVGVEKAASAAGLSIHVPFAPGRVDARQDQTDIEMFELLEPIADGFRNYRARLDVSTTESLLIDKAQQLTLTAPEMTALVGGMRVLGANFDSSKNGVFTDRVGVLSNDFFVNLLDMRYEWKATDESKELFEGRDRETGEVKYTASRADLVFGSNSVLRAVAEVYASSDAHEKFVKDFVAAWVKVMNLDRFDLL
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: ISPF_GLOVI
Sequence: MAVGGFEMRIGNGYDFHRLVEGRRLILGGVEIPYRLGLLGHSDADLLTHAITDALLGAACLGDIGRHFPPGDPQWQDVSSLLLLSKVLELVRGRGLRLSNVDAVVVAERPKLAPHIPAIRQSLAGALGLPLDRLSVKATTNEGLGPVGEGLAMACHAVVLLEE
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: PA2B2_AGKBI
Sequence: SLLELGKMILQETGKIAITSYGSYGCNCGWGHRGRPKDA
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits ADP-induced platelet aggregation.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 2, svPLA2, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 II, PLA2-II.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GDN_RAT
Sequence: MNWHFPFFILTTVTLSSVYSQLNSLSLEELGSDTGIQVFNQIIKSQPHENVVISPHGIASILGMLQLGADGRTKKQLSTVMRYNVNGVGKVLKKINKAIVSKKNKDIVTVANAVFVRNGFKVEVPFAARNKEVFQCEVQSVNFQDPASACDAINFWVKNETRGMIDNLLSPNLIDSALTKLVLVNAVYFKGLWKSRFQPENTKKRTFVAGDGKSYQVPMLAQLSVFRSGSTKTPNGLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTINSWMNTMVPKRMQLVLPKFTALAQTDLKEPLKALGITEMFEPSKANFAKITRSESLHVSHILQKAKIEVSEDGTKAAVVTTAILIARSSPPWFIVDRPFLFCIRHNPTGAILFLGQVNKP
What is the function of this protein?
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase.  Promotes neurite extension by inhibiting thrombin.  Binds heparin.
What are the official names of this protein?
Glia-derived nexin, GDN, Peptidase inhibitor 7, PI-7, Protease nexin 1, PN-1, Protease nexin I, Serpin E2.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: FAD6E_ARATH
Sequence: MGAGGRMPVPTSSKKSETDTTKRVPCEKPPFSVGDLKKAIPPHCFKRSIPRSFSYLISDIIIASCFYYVATNYFSLLPQPLSYLAWPLYWACQGCVLTGIWVIAHECGHHAFSDYQWLDDTVGLIFHSFLLVPYFSWKYSHRRHHSNTGSLERDEVFVPKQKSAIKWYGKYLNNPLGRIMMLTVQFVLGWPLYLAFNVSGRPYDGFACHFFPNAPIYNDRERLQIYLSDAGILAVCFGLYRYAAAQGMASMICLYGVPLLIVNAFLVLITYLQHTHPSLPHYDSSEWDWLRGALATVDRDYGILNKVFHNITDTHVAHHLFSTMPHYNAMEATKAIKPILGDYYQFDGTPWYVAMYREAKECIYVEPDREGDKKGVYWYNNKL
What is the function of this protein?
ER (microsomal) omega-6 fatty acid desaturase introduces the second double bond in the biosynthesis of 18:3 fatty acids, important constituents of plant membranes (PubMed:14593172, PubMed:7907506).  Delta(12)-desaturase with regioselectivity determined by the double bond (delta(9) position) and carboxyl group of the substrate.  Can use both 16:1 and 18:1 fatty acids as substrates (PubMed:8685264).  It is thought to use cytochrome b5 as an electron donor and to act on fatty acids esterified to phosphatidylcholine (PC) and, possibly, other phospholipids (PubMed:14593172, PubMed:7907506, PubMed:1730697).  Very low constitutive hydroxylation activity (PubMed:11864983).  Required for desaturation of fatty acids present in extraplastidial membranes, including mitochondria (PubMed:11104757, PubMed:17507388).  Required for salt tolerance during seed germination and early seedling growth (PubMed:22279586).
What are the official names of this protein?
Delta(12)-fatty-acid desaturase, Fatty acid desaturase 2, Omega-6 fatty acid desaturase, endoplasmic reticulum.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Protein: WECF_SHIBS
Sequence: MTVLIHVLGSDIPHHNRTVLRFFNDALAATSEHAREFMVVGKDDGLSDSCPALSVQFFPGKKSLAEAVIAKAKANRQQRFFFHGQFNPTLWLALLSGGIKPSQFFWHIWGADLYELSSGLRYKLFYPLRRLAQKRVGCVFATRGDLSFFAKTHPKVRGELLYFPTRMDPSLNTMANDRQREGKMTILVGNSGDRSNDHIAALRAVHQQFGDTVKVVVPMGYPPNNEAYIEEVRQAGLELFSEENLQILSEKLEFDAYLALLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNRENPFWQDMTEQHLPVLFTTDDLNEDIVREAQRQLASVDKNTIAFFSPNYLQGWQRVLAIAAGEVA
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
What are the official names of this protein?
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase, 4-alpha-L-fucosyltransferase, TDP-Fuc4NAc:lipid II Fuc4NAc transferase, Fuc4NAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 56 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MURA_ECOBW
Sequence: MDKFRVQGPTKLQGEVTISGAKNAALPNLFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPF_FRATH
Sequence: MSFRIGHGYDVHKFTSAKQNIIIGGVEIAYHLGLEAHSDGDVLIHALCDAILGALGLGDIGKHFLDTDNQFKNIDSKFFLAEIKKMLDEKQYSISNIDCTIIAQAPKMLPHIEKMRACLANILEIQISQINIKATTTERLGFIGREEGIATHVVCLLYR
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: CD3G_BOVIN
Sequence: MEQGKHLAGLILAVFLLQGTMAHVKEVKVDDNREDGSVILICVTNDTTITWLKDVEQIGSGDTKKNTWNLGSSTKDPRGIYKCEGSNNQSKSLQIYYRMCQNCIELNPSTVAGFIFTEIVSIFLLAVGVYFIAGQEGVRQSRASDKQTLLNNDQLYQPLKEREDDQYSHLRKN
What is the function of this protein?
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.  When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.  All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.  Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.  In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface.  Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
What are the official names of this protein?
T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RPOZ_SHEB9
Sequence: MARVTVEDAVEQIGNRFDMILVAARRARQIAVQGKDPMVEEMNDKPTVIALREIELGLVNAHTLDADERQTVREREAAEIAAVSAIAEGRSL
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.