PharMolix/UniProtQA huggingface dataset:
Protein: LEU3_PROM9
Sequence: MKNYKIVLLSGDGIGPEISEVSKKVLKKLSRKHNFNIEIIEKLFGGIAYEKYGTPAPDETLDQCKKCDAVLLACVGDIKYDSLARELRPESGLLKLRSALGLFANIRPVKIRKSLVNTSTLKKEIVENVDLIVVRELIGGIYFGKPRGHITNTKIPKAFNTMVYDSAEIERITEIAIKIANQRNKKICSVDKSNVLEVSQLWRDTVLNITLKDKNISLSNMYVDNAAMQLVRDPSQFDVILTSNLFGDILSDLAAMLTGSIGMLPSASLNNNGPGVFEPVHGSAPDIAGKNIANPIAMLLSASMMLKIGLNEEEAAKNLETAVDKVLAEGFRTADLADGSSEVLSCSEIGDKIIDEI
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2117_SHEWM
Sequence: MSFWKEKSLAQLDTQEWESLCDGCGKCCLNKLIDDETEELYYTNAACKLLDHQDGHCVHYQERFTFVPSCTQVTVDNVAQLTWLPDSCAYRRLYLGRELPSWHPLITGSKAAMHEAGMSTQNKVKCETKVRYIEDHIVLWPMRDLD
What are the official names of this protein?
UPF0260 protein Swoo_2117.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: VE6_HPV2A
Sequence: MSEENPCPRNIFLLCKEYGLELEDLRLLCVWCKRPLSEADIWAFAIKELFVVWRKGFPFGACGKCLIAAGKLRQYRHWHYSCYGDTVETETGIPIPQLFMRCYICHKPLSWEEKEALLVGNKRFHNISGRWTGHCMNCGSSCTATDPASRTLH
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation.  In turn, apoptosis induced by DNA damage is inhibited.  E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: COAD_BURVG
Sequence: MVVAVYPGTFDPLTRGHEDLVRRASSIFDTLVVGVADSRAKKPFFSLEERLKIANEVLGHYPNVKVMGFKGLLKDFVRTNNARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETMFMTPSDQYQFISGTIVREIAQLGGDVSKFVFPSVEKWLTEKVAAMGGPAA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDRD_METAC
Sequence: MAKKTPSIDTKNLTAVQLMELDSCTRCGECVKWCPTYAASGQKPGLAPRDKILRWRQYMNKSYGLKAKLFGPTEIPQSELEEFKDDVHGCTTCGICATVCESGINTVELWESLRTNLVKKGIGPFGKQGMFPKLIGQYHNPYLLDQKDRLAWVPPDVKIADKANIVYFTGCTAGYKQLALAFATSRVLNKLGIEFTMLGEDEWCCGSALIRTGQVHVNDVAKELAKHNVEAIKAKGATKVLYACAGCFRASKVDWPRLLGEELPFEVVHITEFLEDLIKKDKIKWEKSLDKTVTYHDPCHLGRHVGVFEPPRYVLSHIPGVKFVEMDRVKEFQRCCGAGGGVKAGIPDLALSVAESRVKDALDTNADVLSSACPFCKRNLMDGRDSLKADIEVEDVIVLVAQALGLSVE
What is the function of this protein?
Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
What are the official names of this protein?
Dihydromethanophenazine:CoB--CoM heterodisulfide reductase subunit D, CoB--CoM heterodisulfide reductase iron-sulfur subunit D, Coenzyme B:coenzyme M:methanophenazine oxidoreductase subunit D.
What is the protein family that this protein belongs to?
Belongs to the HdrD family.
Protein: HEM3_FRATH
Sequence: MKQITIASRESKLALWQTNFVKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLKDVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGDYDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCHVAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: NU2M_MARPN
Sequence: MNPHATPVLVLSLALGTTITISSNHWVLAWTGLEINTLAIIPLISKSHHPRAVEAATKYFLTQAAASALVLFSSMTNAWATGQWDITQLNHPTSCLLLTAAIAIKLGLVPFHFWFPEVLQGSPLMTALLLSTLMKFPPLTLLLMTSKSLNPALLTTMALASAALGGWMGLNQTQTRKILAFSSISHLGWIAIILVYSPKLALLTFYLYTIMTSAVFMALNKIKALNMSMVLTSWTKTPVLNATLMLMLLSLAGLPPLTGFMPKWLIIQELTKQEMTPAAMAIAMLSLLSLFFYLRLAYHSTITLPPNSSNHMKQWYTSKPPSTPTAILASLSILLLPLSPMVHAIV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KRB2C_SHEEP
Sequence: MACCSTSFCGFPICSTAGTCGSSCCRSTCSQTSCCQPTSIQTSCCQPTCLQTSGCETGCGIGGSTGYGQVGSSGAVSSRTRWCRPDCRVEGTSLPPCCVVSCTSPSCCQLYYAQASCCRPSYCGQSCCRPACCCQPTCTEPVCEPTCSQPIC
What is the function of this protein?
The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins.  The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).
What are the official names of this protein?
Keratin, high-sulfur matrix protein, B2C.
Protein: SC6A9_MOUSE
Sequence: MIGGDTRAASAHPGMASAQGPVATPSPEQPFPGTTSVSLARPVLRVWHGAHSSGLLPNLIAQHSPAMAQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPAALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRFQDSRI
What is the function of this protein?
Sodium- and chloride-dependent glycine transporter.
What are the official names of this protein?
Sodium- and chloride-dependent glycine transporter 1, GlyT-1, GlyT1, Solute carrier family 6 member 9.
What is the protein family that this protein belongs to?
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GPMA_BUCAI
Sequence: MKINQVVLIRHGQSEWNTLNKFTGWHDAELDKKGKDEAKFAAILLKKEKFFFDCAHTSLLKRAIHTLQYILDELNQTWLSVKKSWRLNERHYGALEGLNKDEVIEKYGQKQVLLWRRSFDISPPQINIKDKRFPGNDPRYSHLNIHDIPLGESLEKTAKRVIPYWNKIVYPELKNNKKILIVAHGNSLRALIQHLYKIDNKAILDLNIPTAQPIILDFDNEKNPIKWHYLT
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: CYB_ODOHE
Sequence: MTNIRKTHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYTFLETWNIGVILLFTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAMVHLLFLHETGSNNPTGIPSDADKIPFHPYYTIKDILGALLLTLFLMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPECYFLFAYAILRSIPNKLGGVLALVLSILILVLMPLLHTSKQRSMMFRPFSQCLFWILVAHLLTLTWIGGQPVEHPFIIIGQLASILYFLIILVLMPVTSTIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RECA_BACC2
Sequence: MSDRQAALDMALKQIEKQFGKGSIMKLGEQAERRISTISSGSLALDVALGVGGYPRGRIIEIYGPESSGKTTVSLHAIAEVQRQGGQAAFIDAEHAMDPVYAQKLGVNIDELLLSQPDTGEQGLEIAEALVRSGAVDIIVIDSVAALVPKAEIEGDMGDSHVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSTVRLEVRRAEQLKQGNDIVGNKTKVKVVKNKVAPPFRVAEVDIMYGEGISREGEILDMASELDIVQKSGAWYSYNEERLGQGRENSKQFLKENTDLREEIAFFVRDHHGIGEDSGVEDTEDATLQD
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGPA1_PIG
Sequence: MFSKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFENFVTIEASLKQKGHKSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTGNSLKIRREGVRLFLLWLQALQNNCSREQLWMFSCLIPGFSAPQSEYGPRTLDNLINPPLNLQETQVTIEEITPLVPPQSGDKGQEDLTSYFLEALLKYIVIQVKSLEWKNKENQERGFSFLFSHFKKYYLPYIFPNICKENSLYHPVLDIPQMRPKPHYVMIKKDAETNEAIYCTKEPFIKARVIVIRWLVSFWLEPKPHTGPHIPGMEGEVLPKNIQ
What is the function of this protein?
Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
What are the official names of this protein?
Ral GTPase-activating protein subunit alpha-1, GAP-related-interacting partner to E12, GRIPE, GTPase-activating Rap/Ran-GAP domain-like 1, Tuberin-like protein 1, p240.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated to the nucleus, when associated with TCF3/E12.
Protein: GALT6_HUMAN
Sequence: MRLLRRRHMPLRLAMVGCAFVLFLFLLHRDVSSREEATEKPWLKSLVSRKDHVLDLMLEAMNNLRDSMPKLQIRAPEAQQTLFSINQSCLPGFYTPAELKPFWERPPQDPNAPGADGKAFQKSKWTPLETQEKEEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRCPPLATTSVIIVFHNEAWSTLLRTVYSVLHTTPAILLKEIILVDDASTEEHLKEKLEQYVKQLQVVRVVRQEERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTVVVSPDIVTIDLNTFEFAKPVQRGRVHSRGNFDWSLTFGWETLPPHEKQRRKDETYPIKSPTFAGGLFSISKSYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGTSVIARNQVRLAEVWMDSYKKIFYRRNLQAAKMAQEKSFGDISERLQLREQLHCHNFSWYLHNVYPEMFVPDLTPTFYGAIKNLGTNQCLDVGENNRGGKPLIMYSCHGLGGNQYFEYTTQRDLRHNIAKQLCLHVSKGALGLGSCHFTGKNSQVPKDEEWELAQDQLIRNSGSGTCLTSQDKKPAMAPCNPSDPHQLWLFV
What is the function of this protein?
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:10464263, PubMed:31932717).  May participate in synthesis of oncofetal fibronectin (PubMed:10464263).  Has activity toward MUC1A, MUC2, EA2 and fibronectin peptides (PubMed:10464263).  Glycosylates FGF23 (PubMed:31932717).
What are the official names of this protein?
Polypeptide N-acetylgalactosaminyltransferase 6, Polypeptide GalNAc transferase 6, GalNAc-T6, pp-GaNTase 6, Protein-UDP acetylgalactosaminyltransferase 6, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: PDXJ_BACFN
Sequence: MTKLSVNINKVATLRNARGGNVPNVVKVALDCESFGADGITVHPRPDERHIRRSDVYDLRPLLRTEFNIEGYPSPEFIDLVLKVKPHQVTLVPDDPSQITSNSGWDTKVNFDFLTEVLDEFNGAGIRTSVFVAPDAEMIEYAAKAGADRVELYTEPYATAYPKDPAAAVAPFVEAAKAARRLGIGLNAGHDLSLLNLNYFYKNIPWLDEVSIGHALISDALYLGLERTIQEYKNCLR
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_XYLF2
Sequence: MADLVPVLTIDGPSGVGKGTVSKIVAARLGWHYLDSGALYRAVAVAADWAAVDVSDTTALVKCAFDTCVNFAECADGEMRVLVNSIDATDVLRMETTGVLASTIASISEVRATLKKRQQMFRRTPGLVADGRDMGTVIFPDAKYKVFLTAKAEERAQRRYKQLMKKGVSVMFGALLEEIRARDARDACRSVAPLKPADDALLIDSTCMEVDEVVAQVLALVTD
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMF_VIBVU
Sequence: MHSNVYLPETFLEKIKTILPSALNMDDFIAYCQQPLRKSIRVNTLKISVDAFLTIAQEKGWTLHPVPWCETGFWIEADESKVPLGNTAEHMCGLFYIQEASSMMPVSALFLGENQFESVLDTAAAPGSKTTQIAALMNNQGILVANEYAASRVKVLHANIERCGVRNAALSNFDGRVFGGWLPESFDAVLLDAPCSGEGTVRKDEDAMKNWSQESVLEIAATQKDLIESAFQALKPGGVMVYSTCTLSEEENQQVCHHLKHTFGDAVAFESLSSLFDGAEKALTEDGFLHIFPQVYDSEGFFVARIRKLASVNSPDVNKKMGKFPFQKASKKESALIEKSLSDSLDISLPADSTIWLRDNDVWLFPNALEPMLGELRFSRMGIKLAEKHKNGYRWQHQIATTLASGDEKTVVDIDTDAAREWFMGRDIYPENSGKGEVFVRYQGAIIGLGKWVSNKIKNGLPRELVRDKNLF
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGB_ENTFA
Sequence: MAKDLLLEIGLEEMPAHVVTPSRIQLEEKVIKFLDEHHLDYETVQSFATPRRLAVKVTAIPEKQADVEEEVKGPAKKIALDAEGNWSKAAQGFVRGQGVTTEDIVFKELNGVEYVYVTKFTKGQSAKEVLTKLNDVITSLTFPVTMHWANYDFEYIRPIHWIVALLDDEVIPFKVLDVTTGQTSRGHRFLGDDVTFQHANEYEAKLKEQFVVVQPNERKQMIVDQANALAAEKNWQLALDEELLEEVTNLVEYPTAFVGSFDEKYLSVPDEVLVTSMKEHQRYFDVRNDQGLLMPHFIAVRNGDNVHLENVIKGNEKVLIARLEDAEFFYNEDKKLTIEACVEKLKNVTFHEKIGSIYEKMQRVALIAQIIGRKVGLSEDELEDLKRASEIYKFDLVTNMVGEFPELQGIMGEKYALLQGEKPAVATAIREHYLPTSSEGELPETAIGAVLALADKLDSVFSFFSVGMIPTGSNDPYALRRQTYGVIRIIEDKGWTFPLVQLQTEVDEAVNQDVEKYGVLLNEGQAEVVEFVKARLRQLLMTKNVRHDIIDAVVSAEQADLSKLFASANILKSRFEDQDFKPSMEALTRVINLAKKGQELLGDTEEGIDPSLFENKAEKELYQAVNDLSEAFATRTIAENYEALVNLRPLIDAYFNETMVMVEDEKVKQNRLKQLMQIAKMALSIASLDLLIVK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_FRATW
Sequence: MNNLEAILRLKTIDAAKKLLGHFLVSKYNNKILIGKIVETEAYLYNDPACHSYSNRTKRNSMMYAQAGTSYVYFTYGMHYCFNVVTADVGIGEAILIRALEPIAGIEQMQLNRSKTKLIDLCSGPAKLTQALNINLKDNGINLLDKDSSILLRYNNDLINEIDIVQTQRIGISKAKDMPYRFYIKDNIFVSKK
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: DER_PAEAT
Sequence: MAENLAALDDDEAELRAATLRAGLDDYDLDEEDAALLSGEYGDEGDEGPLKLDPVLAIIGRPNVGKSTLVNRILGRREAVVEDTPGVTRDRVMYSARWNGRNFTLVDTGGWEHDAKGIHARVAEQAEMAVELADAVLFVVDSAVGATATDEGVMKMLRKSKKPVIMVANKVDDFAQEADSATLWGLGFGEPYPVSALHGRGVADLLDHVMDTLPEYSLVDGVERSGGPRRIALIGRPNVGKSSLLNKLAGSERVVVDPLAGTTRDPVDEFIELGDRTWRFVDTAGIRRRQHMAQGADFYASLRTQAALEKAEVAVVLLAVDEVLSEQDVRILQLAIESGRALVLAFNKWDLLDDERRRYLEREIEQDLAHVEWAPRVNISAKTGWHKDRLVPALDIALESWDRRIPTGRLNAFLGELVAAHPHPVRGGKQPRILFGTQASSRPPKFVLFTTGFLDPGYRRFITRRLRETFGFEGTPIEVNMRVREKRGKKR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: S14L5_XENTR
Sequence: MVQKYQSPVRVYKYPFELVMAAYEKRFPTCPQIPVFLGSDILQEHKSEDGALHVVERSCKLNVDAPRLLKKIAGVEFVYFIQKNTVNWKDRTLLIEAHNETFSSRVLVNETCSYSVHPENEEWTCFEQTASLDIKSFFGFESTVEKIAMKQYTANIKRGKEVIEFYLNELISQGITHLPKWTPGVPAGWHPLQAFRSGITRSNQAEQTASQGPCKADAGSHSLAAEPSTPDTDKLEADYIERYLGQLTPMQESALIHLRQWLQETHKGKIPKDEHILRFLRARDFNMEKAREMLCQSLSWRKQHQVDYILQTWQPPRVLEEYYAGGWHYHDKDGRPLYILRLGQVDTKGLVKALGEEAILRHVLSINEEGQKRCEENTRQFGRPIWSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLIVRAPRVFPVLWTLVSPFINENSRQKFLIYSGNNYQGPGGIADYVDKEIVPDFLGGECVCNIPEGGLVPKSLYQSDEDAEMSDHIRLWTETIYQSSCVWKGAPHEIIVEILEEESVITWDFDILRGDVIFSLFHSKRAPDTRQRELALAAGNAPSSNVQLIDKSWTLGVDYSRVQAPLVCREGESIQGSHVTRWPGIYILQWKMHSSASGSSMARVDDVLASLQGSSHKCKLMYYFEVLASEDFRGSMSSLESCSGFSQLSGVTNTSSKSHSSSLISR
What are the official names of this protein?
SEC14-like protein 5.
Protein: LHX8_MOUSE
Sequence: MYWKSDQMFVCKLEGKEVPELAVPREKCPGLMSEECGRPAALAAGRTRKGAGEEGLVNPEGAGDEDSCSSSAPLSPSSSPQSMASGSVCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHFDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPSSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHQQLLDSSPCYPIQ
What is the function of this protein?
Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
What are the official names of this protein?
LIM/homeobox protein Lhx8, LIM homeobox protein 8, L3, LIM/homeobox protein Lhx7, LIM homeobox protein 7.
What are the subcellular locations of this protein?
Nucleus.
Protein: YQGF_RHOCS
Sequence: MAIRNLMELKASLPRNGRLMGLDLGEKTIGLAVSDPGLSVASPVGTIRRTKFTQDAQELARAMRDRDVRALVVGLPVNMDGTEGPRCQSVREFSRLLLQRPQLFGFEPEIAFWDERLSTSAVERMMIGWDMTRKRRDEVVDKMAAAYILQGALDRLRQGDAAPGGSDDERDEDGDTDGEDGGGDGGGE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFI1_SCHPO
Sequence: MTEGVTVQKVQSASSNGHKPNTVISQIISEMQSLLGSSFEVYTKTMTDFLIGQLSRKEMKSMLLTFAGKSNFDKLHNSIIFHILKLMQKNNDTFSALHHLPWFKRKKVDNSLFLHKKISSQNAQVRLIKRIVMSLSYKDRARIKTALKEKPVTPSLISGLLLETRIAKLPKIPVSRDKLNSVFVNDIKAGYVAPLACETLELPDSESLKERITAISLENGLLGGVQKGVSDIILAGLESHLKNILSRCFSILNKNIRQKNTENDAAGFTINDLNLAWTIEPHAFVEQYPQKLRMPFLLHDSYTEDEISICAESPSYMLASNDAQSDRNSVASLLDEVLS
What is the function of this protein?
Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK.  SAGA is involved in RNA polymerase II-dependent transcriptional regulation.  At the promoters, SAGA is required for recruitment of the basal transcription machinery.  It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination.  SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac).  SAGA interacts with DNA via upstream activating sequences (UASs).  SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation.  SLIK is proposed to have partly overlapping functions with SAGA.  It preferentially acetylates methylated histone H3 (By similarity).
What are the official names of this protein?
Transcriptional coactivator hfi1.
What is the protein family that this protein belongs to?
Belongs to the HFI1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OGT_METAC
Sequence: MYYAIFESPIGPILLAGDEEGLKYVNFMKGKKKIEVPDSWVENEEFFREASRQLEAYFAGELKSFDVKLAPEGTEFQKSVWNALKEIPYGETRTYGEIAKNIGNPKASRAVGLANNRNPIAIIVPCHRVIGANGKLTGYASGLDIKEFLLKLEGSC
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG147_VACCW
Sequence: MITLFLILCYFILIFNIIVPAISEKMRRERAAYVNYKRLNKNFICVDDRLFSYNFTTSGIKAKVAVDNKNVPIPCSKINEVNNNKDVDTLYCDKDRDDIPGFARSCYRAYSDLFFTT
What is the function of this protein?
Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry.  Also plays a role in cell-cell fusion (syncytium formation).
What are the official names of this protein?
Virion membrane protein OPG147.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG147 family.
Protein: GAG_SFV3L
Sequence: MGDHNLNVQELLNLFQNLGIPRQPNHREVIGLRMLGGWWGPGTRYILVSIFLQDDSGQPLQQPRWRPEGRPVNPLVHNTIEAPWGELRQAFEDLDVAEGTLRFGPLANGNWIPGDEYSMEFQPPLAQEIAQMQRDELEEILDITGQICAQVIDLVDMQDAQIRGLERRIQDRLGLRDNLPVAGIQAPPSSPIGQPIASSSLQPIPGSSSSPADLDGIWTPRQIDPRLSRVAYNPFLPGSSDGSGGSIPVQPSAPPAVLPSLPSLPAPVSQPIIQYVAQPPVPAPQAIPIQHIRAVTGNTPTNPRDIPMWLGRHSAAIEGVFPMTTPDLRCRVVNALIGGSLGLSLEPIHCVNWAAVVAALYVRTHGSYPIHELANVLRAVVTQEGVATGFQLGIMLSNQDYNLVWGILRPLLPGQAVVTAMQQRLDQEVNDAARITSFNGHLNDIYQLLGLNARGQSIARAQSASTSGNSASAGRGRRGQRTQQQAGRQQQQQTRRTNQGNQGQRDNNQRQSSGGNQGQRGQGGYDLRPRTYQPQRYGGGRGRRWNDNQQQQQAQPGRSSDQPRSQSQQPQPEARGDQSRTSGAGRGQQGRGNQNRNQRRADANNTRNVDTVTATTTSSSTASSGQNGSSTTPPASGSRNQGD
What is the function of this protein?
Involved in capsid formation and genome binding.  Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome (By similarity).
What are the official names of this protein?
Gag polyprotein, Pr71Gag.
What are the subcellular locations of this protein?
[Gag protein]: Virion. Host nucleus. Host cytoplasm. Note=Gag protein is nuclear at initial phase, cytoplasmic at assembly. Shortly after infection, Gag protein is targeted to centrosomes. It is then actively transported into the nucleus thanks to its nuclear localization signal. In the late phases of infection, Gag proteins assemble in the cytoplasm to form the virion's capsids (By similarity). SUBCELLULAR LOCATION: [p3]: Virion.