PharMolix/UniProtQA huggingface dataset:
Protein: PSAJ_CHAGL
Sequence: MQYFKTYLSTAPVIATIWFGFLAGLLIEINRFFPDALVLPYL
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NBLIK_THEFY
Sequence: MQSEMHPELAKLSFLLGRWEGLGVAGYPDTEEFQFTQVIEFTHDGHPHLNYRSQVWRVNEDGSRGEPVTSESGYWRVRTGKAAQQEDPDQPPIHVEVLISHPEGYSEVYLGTVFAHRVELHTDVVVRTETGLPAAASHRLYGLFGDNRETLGYAWDLAANSKELQPYMSAQLQRVDRKS
What are the official names of this protein?
Ferric nitrobindin-like protein.
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: PYRC_FUSNN
Sequence: MLLKNCKILKNTKFEKVDILIRDNKIEKISENIDITDENIIDIKNRFVTAGFIDVHVHWREPGFSKKETVYTASRAAARGGFTTVMTMPNLNPVPDSVETLNKQLEIIKKDSVIRAIPYGAITKEEYGRELSDMEAIASNVFAFTDDGRGVQSANVMYEAMLMGAKLNKAIVAHCEDNSLIRGGAMHEGKRSAELGIKGIPSICESTQIVRDVLLAEAANCHYHVCHISAKESVRAVREGKKNGIKVTCEVTPHHLLSCDEDIKEDNGMWKMNPPLRSREDRNALIVGILDGTIDIIATDHAPHTMEEKIRGIEKSSFGIVGSETAFAQLYTKFVKTDIFSLEMLVKLMSENVAKIFDLPYGKLEENSFADIVVIDLEKEITINPNNFLSKGKNTPYINEKINGIPVLTISNGKIAYIDKEEINL
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: SYA_MYCTU
Sequence: MQTHEIRKRFLDHFVKAGHTEVPSASVILDDPNLLFVNAGMVQFVPFFLGQRTPPYPTATSIQKCIRTPDIDEVGITTRHNTFFQMAGNFSFGDYFKRGAIELAWALLTNSLAAGGYGLDPERIWTTVYFDDDEAVRLWQEVAGLPAERIQRRGMADNYWSMGIPGPCGPSSEIYYDRGPEFGPAGGPIVSEDRYLEVWNLVFMQNERGEGTTKEDYQILGPLPRKNIDTGMGVERIALVLQDVHNVYETDLLRPVIDTVARVAARAYDVGNHEDDVRYRIIADHSRTAAILIGDGVSPGNDGRGYVLRRLLRRVIRSAKLLGIDAAIVGDLMATVRNAMGPSYPELVADFERISRIAVAEETAFNRTLASGSRLFEEVASSTKKSGATVLSGSDAFTLHDTYGFPIELTLEMAAETGLQVDEIGFRELMAEQRRRAKADAAARKHAHADLSAYRELVDAGATEFTGFDELRSQARILGIFVDGKRVPVVAHGVAGGAGEGQRVELVLDRTPLYAESGGQIADEGTISGTGSSEAARAAVTDVQKIAKTLWVHRVNVESGEFVEGDTVIAAVDPGWRRGATQGHSGTHMVHAALRQVLGPNAVQAGSLNRPGYLRFDFNWQGPLTDDQRTQVEEVTNEAVQADFEVRTFTEQLDKAKAMGAIALFGESYPDEVRVVEMGGPFSLELCGGTHVSNTAQIGPVTILGESSIGSGVRRVEAYVGLDSFRHLAKERALMAGLASSLKVPSEEVPARVANLVERLRAAEKELERVRMASARAAATNAAAGAQRIGNVRLVAQRMSGGMTAADLRSLIGDIRGKLGSEPAVVALIAEGESQTVPYAVAANPAAQDLGIRANDLVKQLAVAVEGRGGGKADLAQGSGKNPTGIDAALDAVRSEIAVIARVG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_STRP1
Sequence: MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSNEDVNDFAKNLLAAKRELTYCSICGNLTDDDPCHICTDTSRDQTTILVVEDAKDVSAMEKIQEYHGYYHVLHGLISPMNGVGPDDINLKSLITRLMDGKVSEVIVATNATADGEATSMYISRVLKPAGIKVTRLARGLAVGSDIEYADEVTLLRAIENRTEL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: FLIZ_ECOLI
Sequence: MMVQHLKRRPLSRYLKDFKHSQTHCAHCRKLLDRITLVRDGKIVNKIEISRLDTLLDENGWQTEQKSWAALCRFCGDLHCKTQSDFFDIIGFKQFLFEQTEMSPGTVREYVVRLRRLGNHLHEQNISLDQLQDGFLDEILAPWLPTTSTNNYRIALRKYQHYQRQTCTRLVQKSSSLPSSDIY
What is the function of this protein?
During the post-exponential growth phase transiently interferes with RpoS (sigma S) activity without affecting expression of RpoS itself.  It is probably not an anti-sigma factor as its overexpression is detrimental in rapidly growing cells where there is almost no sigma S factor.  There is a strong overlap between Crl-activated genes and FliZ-down-regulated genes.  FliZ acts as a timing device for expression of the genes for the adhesive curli fimbriae by indirectly decreasing expression of the curli regulator CsgD.
What are the official names of this protein?
Regulator of sigma S factor FliZ.
Protein: TYSY_COXBR
Sequence: MKEYLNFLQFILDHGVAKTDRTGIGTKSVFGYEMRFNLREGFPLVTTKKIHLKSVIYELLWFLRGDTNIQFLNDNGVTIWDEWADENGDLGPIYGKQWRRWHCPDGRTVDQMQRLIREIKTNPDSRRLIVSAWNVGELDQMALPPCHLLFQFYVADGFLSCKLTQRSADAFLGVPFNIASYSLLTHLIARQCNLKAGEFIWSGGDCHIYNTHQDQVSTQLSREPRALPQLIINRDPSSLYDYNFNDFSIVNYHPHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFD_METAC
Sequence: MTSFTVSPPPHIKKKIFIKNLIWSRIVALLPISAAAVYFFGFAALGNIIASILGAVGIEFVIQKAFNKKLTIMDGNAIYLGLLLALICPPTLPAWMIFIGGAFAVGVGKHAFGGIGSYTFHPSLAAWVFLSLAWAQDMLPGTIPILSSFSDLILENGAGFLTDVSPILVLLAGVILILVKYIEWRIPLSYLLTTVILALVLGDPLAYVVSGTFLLGVFFIATETVTSPVTQNGRIVYGILCGFLTVIYGYFSGNYVWGTLYALLLSNAVAPFIELKTLPKPMGGVANE
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Catalyzes Na(+) transport, most probably coupled to electron transfer from reduced ferredoxin to methanophenazine and heterodisulfide reductase.  Involved in heterodisulfide reduction during methanogenesis from acetate.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y703_TREPA
Sequence: MGAERVGRAPGVNAKRAVQTQGVQSPSVKRSVRWVRGLCEVLLFSGVFVSAVSFLLHSAAVPPPERQVVPAHFERIAMQFPRQVSQGACAMATFSLVALQEKDKAHTEVHLVLRTPAGKEAKTVRAFALPPKGIAQLGTDAATAGVSRAGSQDVTHVALLGISIFWEPGDWMLEAQVRVPGGKPYVRRAPLRIEKKEFPREELRLDRKNTAIAQDKSERKKVQRDA
What are the official names of this protein?
Uncharacterized protein TP_0703.
Protein: ARGR_ECO81
Sequence: MRSSAKQEELVKAFKALLKEEKFSSQGEIVAALQEQGFDNINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKELYEAILELFDQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOTO_HUMAN
Sequence: MPSPRPRGSPPPAPSGSRVRPPRSGRSPAPRSPTGPNTPRAPGRFESPFSVEAILARPDPCAPAASQPSGSACVHPAFWTAASLCATGGLPWACPTSWLPAYLSVGFYPVPGPRVAPVCGLLGFGVTGLELAHCSGLWAFPDWAPTEDLQDTERQQKRVRTMFNLEQLEELEKVFAKQHNLVGKKRAQLAARLKLTENQVRVWFQNRRVKYQKQQKLRAAVTSAEAASLDEPSSSSIASIQSDDAESGVDG
What is the function of this protein?
Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development.  Required for node morphogenesis.  Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function.  Plays a role in regulating axial versus paraxial cell fate.  Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By similarity).
What are the official names of this protein?
Homeobox protein notochord.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYB_CROCP
Sequence: MTNIRKTHPLMKIVNSSFIDLPAPSNISSWWNFGSLLGICLITQILTGLFLAMHYTSDTVTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGLYYGSYMYLETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIVAALAGVHLLFLHETGSNNPSGLNSDTDKIPFHPYYTIKDILGALIMISMLSSLVLFSPDMLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILMIIPLLHTAKQRSMMFRPMSQCLFWILVADLLTLTWIGGQPVEYPFVVIGQLASVIYFLIILFIMPITSMIENQLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL27_CLONN
Sequence: MLLMNLQLFAHKKGVGSSKNGRDSESKRLGTKCGDGQFVLAGNILVRQRGTKIHPGVNVGRGGDDTLYAKVDGIVKYERVGRSKKQASVYPVEIENVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: ISPE_SALPA
Sequence: MTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPRRDGEIHLLTPVNGVENEDNLIVRAAQLLMKIASESGRLPAGSGADISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAEGVGEILTPVNPPEKWYLVAHPGVSIPTPVIFKDPQLPRNTPKRSIDTLLKCEFSNDCEVIARKRFREVDAALSWLLEYAPSRLTGTGACVFAEFDTESCARQVLEQAPEWLNAFVAKGVNLSPLHRELL
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: MPK15_ORYSJ
Sequence: MDFFTEYGEGNRYKIEEVIGKGSYGVVCSALDTHTGEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDIVEIKHILLPPSRREFKDIYVVFELMESDLHQVIKANDDLTPEHYQFFLYQLLRGLKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFSDTPTAIFWTDYVATRWYRAPELCGSFFSKYTPAIDIWSIGCIFAELLTGKPLFPGKNVVHQLDIITDLLGTPSTEAISRIRNEKARRYLSSMRRKKPIPFTQKFPNADPLALRLLERMLSFEPKDRPNAEEALADPYFRNIANVDREPSAQPVTKLEFEFERRRITKEDIRELIYRDILEYHPNMLREYLEGTESAGFMYPSAVDHFKKQFAYLEEHYAKGSTAAPPERQHNSLPRPSVLYSDDRPQNTANIAEDLSKCVLGDNTQKMHQGSASVCANRVPQGGAARPGKVVGSALRYGNCSTSTAEQYEHRRTDRNPALATNTVSPRGSYP
What are the official names of this protein?
Mitogen-activated protein kinase 15, MAP kinase 15.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: PURA_SYNSC
Sequence: MFLANVVVIGAQWGDEGKGKITDLLSRSADVVVRYQGGVNAGHTIVVDDRVLKLHLIPSGILYPDTICLIGSGTVVDPKVMLGELDMLIANDIDISGLRLASTAHVTMPYHRLLDQAMEKQRGARRIGTTGRGIGPTYADKSQRSGIRVIDLLDEQRLRDRLEGPLQEKNELLQTIYGVAPLNAEDVIQEYLGYGKRLAPHVVECTQTIHQAARDRKNILFEGAQGTLLDLDHGTYPYVTSSNPVSGGACIGAGVGPTLIDRVIGVAKAYTTRVGEGPFPTELSGSLNDQLTERGGEFGTTTGRQRRCGWFDGVIGRYAVQVNGLDCLAVTKLDVLDELDEIQVCVAYELNGERIEHFPSSADDFAQCKPIFETLPGWQCSTEECRSLEDLPKPAMDYLRFLADLMEVPIAIVSLGASRDQTIVVEDPIHGPKRALLSA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFIX_MOUSE
Sequence: MVNEYKRIVLLTGLMGINDHDFRMVKSLLSKELKLNRMQDQYDRVKIADLMEDKFPKDAGVDQLIKLYKQIPGLGDIANKLKNEKAKAKRTRTGKRKTAAKRQRQEEPSTSQPMSTTNEDAEPESGRSTPDTQVAQLSLPTASRRNQAIQISPTIASSSGQTSSRSSETLQSIIQSPKTPKRPSSSILDPPVSSGTASSSAQALGVPLATIAKRQRLKNVPKEPSEENGHQQGSKKVMVLKVTEPFSYDVTEEKMFHATVATETEFFRVKVFDIVLKEKFIPNKVLTISNYVGCNGFINIYSASSVSEVNDGEPMNIPLSLRKSANRTPKINYLCSKKRGIFVNGVFTVCKKEEKWNYICYEIGDDTGMMEVEVYGRLTNIACNPGDKLRLICFKLIPDEEKAQLRSTTHSNMQVIKAKN
What are the official names of this protein?
Pyrin and HIN domain-containing protein 1, Interferon-inducible protein 209, Ifi-209, Interferon-inducible protein X, Interferon-inducible protein p209.
What is the protein family that this protein belongs to?
Belongs to the HIN-200 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FREY_BOVIN
Sequence: MVLAMLGALHPRAGLSLFALYLVLAAALLRPQPLRPQRAVPEEFSAPLELSAPLSGLVDDYGVRPKHPWPRGPRPLLSRAQQRKRDGPDMAEYYYDSRL
What is the function of this protein?
Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly.  Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome.  Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP.
What are the official names of this protein?
Protein Frey, Frey regulator of sperm-oocyte fusion 1, FREY1, Uncharacterized protein C11orf94 homolog.
Protein: RUVA_LAWIP
Sequence: MIAYLEGYIAEFGETSCVVATSSGIGYEVFLTTPTRSTLPNKGEQVRFYICHIVREDIQELFGFETWDERQTFIVLTSISKVGARTALNMLSTFRPNDLRQCVIEEDIFALTRVSGIGKKTAQHIFLELKYKLQIDGNSTTSSSPSIGQSLFYDILTGLQGLGYTKEESSVVIKSVLQHEPDLDVGSALRRCLKQLVKG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: DLTA_LISMF
Sequence: MTTSIIERIDAWAEKTPDFPCYEYAGTRLSYKELKRQSDAFGSFLLKNLNTDKEKPIIVYGHMSPLMLVAFLGSIKSGRAYVPVDVSMPVERIEQIKKAADPSLFICTEELPSNLTITGCPVLTQDQLMDALEKHFGEVPDKEACVKNDDNYYIIYTSGSTGNPKGVQISQNNLVSFSNWILQDFSLSQGLRFLNQAPFSFDLSVMDLYPSLLSGGTLVPLDKTITANMKDLYREIPAQNLDVWVSTPSFADLCLLDDNFNQENNPGLIRFLFCGEVLAKKTASELLNRFPDAVIYNTYGPTEATVAVTQVKVTREVIDAYPSLPLGVIKPDMRLHIVDQETGEVLPEGEKGEIVLIGASVSKGYLNEPEKTDQVFFDYKGYQAYRTGDSGIIKDGYLFFQGRLDFQIKLHGYRIELEDIENNLKKVSYIQNCAIIPKMKDEKVDMLVAQVIPTNHDFEKEYQLSAAIKNELKEFMPAYMIPRKWIYKTEFPLTMNGKIDRKALNSEVNK
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP70_LEIMA
Sequence: MTFDGAIGIDLGTTYSCVGVWQNERLDIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFNDSVVQSDMKHWPFKVTTKGDDKPVISVQYRGEEKTFTPEEISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVVRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDRGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKNLASSHRALRRLRTACERAKRTLSSATQATIEIDALFENIDFQATITRARFEELCGDLFRSTIQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNQITITNDKGRLSKD
What are the official names of this protein?
Heat shock 70 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PURL_CORA7
Sequence: MTVHNDTVEQAAAQPELEQPYRELGLKDDEYAHIREILGRRPTDAELTMYSVMWSEHCSYKSSKTHLRYFGETMTEEMGSKILAGIGENAGVVDIGDGNAVTFRVESHNHPSYVEPHQGAATGVGGIVRDIMAMGARPIAVMDQLRFGPADAPDTKRVLPGVVGGISHYGNCLGLPNIGGETVFDESYSGNPLVNALCVGTLKVDDLKLAFASGTGNKVMLFGSRTGLDGIGGVSVLASDTFEDGAERKLPAVQVGDPFAEKVLIECCLELYKSGIVVGIQDLGGAGLACATSELAAAGDGGMEINLDNVPLRAKDMTAAEILASESQERMCAVVTPENVEKFKEICAHWDVTCAEIGEVTTGKHLIIRHQGEVVVDAPAGTIADEAPVYDRPYARPEWQDALQEFKGVEKQDLTVALKKLVASPALCSRDFITEQYDRYVRGNTVQSHHANAGVLRIDEETGRGIAVSADASGRYTKLDPNMGTRLALAEAYRNVAVTGARPVAITNCLNYGSPENPDVMWQFRESVHGLADGAVELGIPVSGGNVSFYNQTGEEPILPTPVVGVLGVIDDVHKSIGNELGLVEEPEVLVLLGETKDEFGGSIWQQVSAREQGNESENGLNGLPPQVDLANEQRLADFFVGNEGVTAAHDLSEGGLAVTAFEMAKRSGVGLNLDLSKVHEDAFVAAFSESASRVLVATTADRVDMLLHRAEECGVPAVVIGQTTDNGELELGGESIAVSELREAWAATLPDLFGHAVGANSVVE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_STAAW
Sequence: MKFAVIGNPISHSLSPVMHRANFNSLGLDDTYEALNIPIEDFHLIKEIISKKELDGFNITIPHKERIIPYLDHVDEQAINAGAVNTVLIKDDKWIGYNTDGIGYVKGLHSVYPDLENAYILILGAGGASKGIAYELAKFVKPKLTVANRTMARFESWNLNINQISLADAEKYLAEFDIVINTTPAGMAGNNESIINLKHLSPNTLMSDIVYIPYKTPILEEAERKGNHIYNGLDMFVYQGAESFKIWTNKDADINSMKTAVLQQLKGE
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: SLMA_ECOLC
Sequence: MAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKDTTARLRLIVLLLLGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEAQLRQVLREKRMREGEGYTTDETLLASQILAFCEGMLSRFVRSEFKYRPTDDFDARWPLIAAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ZNG1F_HUMAN
Sequence: MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTLRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFDVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELCDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT
What is the function of this protein?
Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (By similarity).  Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702).  Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (By similarity).  After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1F to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis (By similarity).  GTP/GDP exchange is required for release of active METAP1 (By similarity).
What are the official names of this protein?
Zinc-regulated GTPase metalloprotein activator 1F, Cobalamin synthase W domain-containing protein 6, COBW domain-containing protein 6.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
Protein: GSA2_MACCJ
Sequence: MNFSNSEAIQNRANAAILGGVNSPSRSYKAVGGGAPVVMARGEGAYFYDVDGNKYIDYLAAYGPIITGHAHPHITEAIKRAAENGVLYGTPTEHEVVFAEMLQEAIPSLEKVRFVNSGTEAVMTTIRVARAYTGRDKIIKFAGCYHGHSDLVLVAAGSGPSQLGTPDSAGVPKSVAQEVITVPFNDIEQFKEAFYHFGDQIAGVLVEPIVGNFGIVEPHAGFLEAVNEVAHSHGALVIYDEVITAFRFCYGGAQDMLGVKPDLTAFGKVIGGGLPIGAYGGRQDIMEHVAPLGPTYQAGTMAGNPLSMQAGIALLEVIKAEGTYDYLDKLGEMLETGMNELIEKYSIKANINRLKGAMTIYFTDEKVENYEQAEATDGEAFAKFFKLMLHQGINLAPSKYEAWFITIAHTEQDIQDTLIAVENSFKQM
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 2, GSA 2, Glutamate-1-semialdehyde aminotransferase 2, GSA-AT 2.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.