PharMolix/UniProtQA huggingface dataset:
Protein: MURC_STRP3
Sequence: MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNITPDMELIVGNAFRENNKEVAYALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTNGSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTEIVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVRVEDLAAKIIKPSQVVTVENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQOR_ACIF5
Sequence: MSRILVLYHSLWGHVEQMAEAEAEGARSVSGIQVDVRRVPETMPAETLAAVHAKTHQAAPEAHPDDLANYDGIIFGTPTRFGNMTGQMRNFLDRTGNLWQEGRLVGKVGSVFVSTATQHGGQETTLTSFHTFLFHQGMLVVGVPYSCTELMNMDEISGGTPYGASTMSKGDGSRQPSANELTIARFQGRHVAEITRKLFG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: KRA33_HUMAN
Sequence: MDCCASRGCSVPTGPATTICSSDKSCRCGVCLPSTCPHTVWLLEPTCCDNCPPPCHIPQPCVPTCFLLNSCQPTPGLETLNLTTFTQPCCEPCLPRGC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 3-3, High sulfur keratin-associated protein 3.3, Keratin-associated protein 3.3.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 3 family.
Protein: DCUP_STAA9
Sequence: MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTPLKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNFTKAMMYRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPVILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLGHGVFPEVQPETLRKVSEFVHTYTQR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COA_ACRMI
Sequence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
What are the official names of this protein?
Collagen alpha chain.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLD15_MOUSE
Sequence: MSVAVETFGFFMSALGLLMLGLTLSNSYWRVSTVHGNVITTNTIFENLWYSCATDSLGVSNCWDFPSMLALSGYVQGCRALMITAILLGFLGLFLGMVGLRCTNVGNMDLSKKAKLLAIAGTLHILAGACGMVAISWYAVNITTDFFNPLYAGTKYELGPALYLGWSASLLSILGGICVFSTCCCSSKEEPATRAGLPYKPSTVVIPRATSDESDISFGKYGKNAYV
What is the function of this protein?
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.  While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules.  Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability.  CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions.  Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis.  Required for normal Na(+)-dependent intestinal nutrient uptake.
What are the official names of this protein?
Claudin-15.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand- like structures in electron microscopy.
Protein: RS3_THEVO
Sequence: MKERKFVNEAVKRLLVYEYLVKETENAGFGKMSMKRTPFGTNITLYVNRPGLVIGRRGSKVQQMTETLEKKYAIETPQIEVKDVKDPDLNPSVIAKKIALSLEKGWSYRKAGNTSLKRTIDAGARGVLIKISGKISGERARYQKFIYGNVKYSGEPGSKGMLVGFSTAKLKVGILGVTVKILNPEYKLPDVFSISNLAGGENVGTESETDKADEQGREAANTEES
What is the function of this protein?
Binds the lower part of the 30S subunit head.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: NUOC_RICFE
Sequence: MTLDKLIEKLAAKSSILITPIIVKDYLAYQVEPNFLLPFLKALKESEELRFTVLTDLFGTDFPERDKRFEVIYNLLSLKLNKRLIIKVYISEKETIPSAMNIFNASCWYEREVYDMYGVNFDGNDDKRRILTDYEFEGHPLRKDFPLTGYTQVKYDEKLKKVAYEPVDLDIEYREFDFSSHWHSPSYVLPGDEKATDVIPAKAGIQK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATP4A_PIG
Sequence: MGKAENYELYQVELGPGPSGDMAAKMSKKKAGRGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILQAQGRKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLSFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPQWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY
What is the function of this protein?
The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells.  Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity).  Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity).  Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2).  The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (PubMed:29618813, PubMed:31436534, PubMed:30143663, PubMed:19387495).
What are the official names of this protein?
Potassium-transporting ATPase alpha chain 1, Gastric H(+)/K(+) ATPase subunit alpha, Proton pump.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localized in the apical canalicular membrane of parietal cells.
Protein: RLPA_RICTY
Sequence: MIIMRNYKFKLESLHQNQKVFRRCTVHSTVLHIISLHEDWSTRLTYKLSLYYCKIKNCYTTFKFEKSNRSIITRAERIINVQHLRRCKDIVDNFSGLISILLVLIFCINLSGCNTSKRLAYDNKYSYKELSKDDPHNLTYIGHYKVGKNYKIKGKIYKPYTPKYFTETGYASWYGGRKDGFHGKKTANGDRFNRNLLTAAHKTLPLPCLVKVTNKANNKSVILMVNDRGPFKKNRIIDVSQKAAEILAFKNQGITKVRIEYLPNETEKFLKKINLKKTENKIFANNYKESLFTKVTKNNQCSINCHIKLVNLKYKLAVNP
What is the function of this protein?
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
What are the official names of this protein?
Endolytic peptidoglycan transglycosylase RlpA.
What is the protein family that this protein belongs to?
Belongs to the RlpA family.
Protein: RK35_CYACA
Sequence: MNIRKNSKSVSKRFKVTSNKLILYKPASKSHLQEKKTVSRKKRLCRVKRIKVVDSKSIKLRYMF
What are the official names of this protein?
50S ribosomal protein L35, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DHX8_DICDI
Sequence: MDKLERIELESQVCNELERFIGSGDKLLAEFVIGLADENPKLKDFNKAISENVPDFPESLSSHLFNLIEKMKKKTTTTTNNNNNNNNNNTNTAKTTTTTTTTTTTTNNNNYKESEWEETKLNSNSNNQKKNQFPGLSIPNKVEWDQGKIVDVPIDDEKTKEELKRKQQDMDREFEREQREKRDRDREQQNKRREIDKEPILYKIYDGKVSSINDYGCFVTLEGIAGRRDGLVHISQILSGRTKLNHPSDVVKRNQQVKVKILSVASSKISLSMKDVDQSTGRDLNPQQNIQSIISTNSTNNRSNPFKPNNNNNNSSNNNNNDDDDKYTTSKNRKRIASPDRWGYKQLIASGILSVPEMPNYDKEVGLVNHDEEQPEEDFDIERNEDEPQFLKGTRMNMQQLSPIKIVKKPNGSLQRAASTQTALSKERKEEKNQQRNEMMDSIPKDLSLPWHDPMPEAGERHLAQEIRSIAGQGIDTEIPEWKKVTQGSHIQYGKATSRSIKEQRESLPIFPLREAFLQAVSEHQLLVVIGETGSGKTTQMAQYLAEAGYGTRGKIGCTQPRRVAAMSVSKRVAEEFGCQLGQEVGYAIRFEDCTSPETIIKFMTDGILLRECLLDPNLSAYSVIILDEAHERTISTDVLFGLLKQALQRRPELKVLITSATLEAEKFSKYFMNAQLFIIPGRTFPVDIRYTKDPEADYLDASLITVMQIHLSEPPGDILLFLTGQEEIDAACQILYERMKSLGSNVPDLIILPVYSALPSEMQTKIFEPAPPGSRKVVIATNIAETSLTIDGIYYVIDPGFSKQKCFNPKNGMDSLVVAPISQAAARQRSGRAGRTGPGKCYRLYTESAFKNEMLASSIPEIQRTNLGNTVLTMKAMGINDLLNFDFMDPPPVQTLVSAMEQLYSLGALDEEGLLTRLGRKMAEFPLDPQLSKMLIASVDLGCSDEILTVVAMLSVQNVFYRPKEKQALADQKKAKFFQPEGDHLTLLNVYESWKNSKFSNPWCFENFVQARSLRRAQDVRKQLITIMDRYKLDIISAGRNYTKIQKAICSGFFANASKKDPNEGYKTLVEGQPVYIHPSSTLFNRNPDWVIYHELVMTTKEYMREVCTIDPKWLVELAPKFFKTSDPNKISKRKRKEKIEPLYDKYNDPNAWRPSKRK
What is the function of this protein?
Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.
What are the official names of this protein?
ATP-dependent RNA helicase dhx8, DEAH box protein 8.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CIRBP_RAT
Sequence: MASDEGKLFVGGLSFDTNEQALEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRSRGRGFSRGGGDRGYGGGRFESRSGGYGGSRDYYASRSQGGSYGYRSSGGSYRDSYDSYATHNE
What is the function of this protein?
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival.  Acts as a translational activator.  Seems to play an essential role in cold-induced suppression of cell proliferation.  Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN.  Acts as a translational repressor.  Promotes assembly of stress granules (SGs), when overexpressed (By similarity).
What are the official names of this protein?
Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
Protein: NCLN_HUMAN
Sequence: MLEEAGEVLENMLKASCLPLGFIVFLPAVLLLVAPPLPAADAAHEFTVYRMQQYDLQGQPYGTRNAVLNTEARTMAAEVLSRRCVLMRLLDFSYEQYQKALRQSAGAVVIILPRAMAAVPQDVVRQFMEIEPEMLAMETAVPVYFAVEDEALLSIYKQTQAASASQGSASAAEVLLRTATANGFQMVTSGVQSKAVSDWLIASVEGRLTGLGGEDLPTIVIVAHYDAFGVAPWLSLGADSNGSGVSVLLELARLFSRLYTYKRTHAAYNLLFFASGGGKFNYQGTKRWLEDNLDHTDSSLLQDNVAFVLCLDTVGRGSSLHLHVSKPPREGTLQHAFLRELETVAAHQFPEVRFSMVHKRINLAEDVLAWEHERFAIRRLPAFTLSHLESHRDGQRSSIMDVRSRVDSKTLTRNTRIIAEALTRVIYNLTEKGTPPDMPVFTEQMQIQQEQLDSVMDWLTNQPRAAQLVDKDSTFLSTLEHHLSRYLKDVKQHHVKADKRDPEFVFYDQLKQVMNAYRVKPAVFDLLLAVGIAAYLGMAYVAVQHFSLLYKTVQRLLVKAKTQ
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522, PubMed:32820719).  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522).  May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity).
What are the official names of this protein?
BOS complex subunit NCLN, Nicalin, Nicastrin-like protein.
What is the protein family that this protein belongs to?
Belongs to the nicastrin family.
Protein: Y3210_ARATH
Sequence: MEACCSDLEVDINGEQTIFLNKQIICAYSGTLRKLLGKSTSSSGNLKVIFNDFPGGAESFEFVSRFCYNDGRVAVMPSNVVFLHCAAKFMEVTKVLEQTEKCMEEIRYWAWPEVLLCLKQCQEVETSPEVDSLAAKLMDALVEKLCLTIEMSPSSAGSACSPDSSLFRFSCDSKSTESFKNCSVRLTWWFDEVLVLSSGLVEMFLKLMVLRKFDNLIISRFLFYYQKVKFCSASSHEKRKILETIIDTLCVLDRSCVPCKSLFAVLRLALGLNINKSCMNKLEVMIGHQLDQATLDNLLVPSPSKSSHLYYVNLVLRFTKAFLDGARSGLQLKKVSSLIDQYIAEVAPDPCLKPSKFLSLITLVPDSARESHEDIYRAIDMYLEAHTGTTDGEKLNLIRTLSYEKLSGESRAHISRNQKFQAIETLDEQQQQQQQQQQQKQLILRMEKVETSGENEKLKEHIEGIQWRVMELERACLKMQNQMEVIKKRSKSSSKGSNRSLPKLCS
What is the function of this protein?
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
BTB/POZ domain-containing protein At3g22104.
What is the protein family that this protein belongs to?
Belongs to the NPH3 family.
Protein: CAS3_METJA
Sequence: MHDIGKITEGFQNNIKKGKRSNKHPHPLYALPIIKNIEFDYLFDIPIEVFAILSHHTQLYNNLYADYQQYKKGTFLIEEIKEFIKNSKEAYESLGFSKFFEFEDLKIEDIPKDAKPLELHRLRRKYWIEANNYIKSLSFDDKIKIKSIFSFMFSILQLCDDFASLNFSEYAKDREGIFDDVLENPEIYVPTLNIDNPISFILKDYEPYKFQKELYNSKNKFVMLFAPCGRGKTEGALLWALNALKNFKRNKIILAMPTQVTSNAMYDRLVKIFGEENVGLFHGKSFIKLRDSKEIEDEDDLEEIRDENFKGNVFFKPITITTIDHVIYSFVHGFSQADFALGNIQNSVIIFDEVHYYEKYTLEHLLTLFDILRRMDIPHLLMSGTLPNFLMNNLEGYELVVDEEGLNYKPFKLKCSENHLIWKEDDEWKVNENIINEIIENYKKGLSQAIILNTVERAREFYKAVRDKVPAILYHSQFAYKDRVKKEDEIFTLEEMRKSQNKPYVIVATQVIEISLDMSVDVMYSELSPPDALGQRAGRLHRKGKDWRENGKEYKLKIFLPYKHLPYSKELIEKTINHIKFYEKPLDYRDIKDFVDNVYKDYNLSIPSDLKLFFDEAILFGRHWTDISTIDEEGRFFKVRDDKFMKIEVVPQVYFDELGENSLRAEYMAKIPAYLILNEMKNEEGLIHFYPYEKRVGRKTRRYLICSFKYTYEIGFDYKEEEEFEDIL
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity (By similarity).
What are the official names of this protein?
Putative CRISPR-associated nuclease/helicase Cas3.
What is the protein family that this protein belongs to?
In the central section; belongs to the CRISPR-associated helicase Cas3 family.
Protein: NADK_SHEB8
Sequence: MGINFDVSRPKARSSINMITKFHTIGLIGKPHHQGTNQTLKRLHHWLTMQGFEVLVEERVAAELGPNIEAVDLLEIGARCDLAIVVGGDGNMLGAARVLARFDLGVIGVNRGNLGFLTDLPPDAFEEALAKVLDGEFDTEHRFLLEAEVYRHGMLKASNTAVNEAVLHPGKIAHMIEFEVYIDDQFMYSQRADGMIVSTPTGSTAYALSAGGAILTPNLQALILVPMFPHTLSCRPIVVDACSTIKMVVSPDNGENLEVSCDGHVHLAVLPGDEIIVRRSSERLRLIHPKGHNYFHVLRTKLGWGSKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWF1_ASPFU
Sequence: MCYYISILIYWGADCRTVGTGPVLMYCTKTIRSYFRCRHPFFSSINSSQIFFLSLLIAGECMFIPSAWPRVSTFHRLFIPALALLPYVFLYASVVTKSYITHENHEDEMARYPYDRVIFNPGHRCRTCDFLKPARSKHCSFCKACVSRHDHHCVWLTNCVGRNNYHYFLSLLLSLSLMLAYGSWLGFSLVSQTLEGLIPSSSPLRSKSQDWTTWLNVWAIAIASDIRVGAVAMLTAMTAPLAMAFLLYHTYLIWAGMTTNESAKWSDWKEDVADGLVFKSTRSEIYGNQSHSDEDTPAQRTWPVSSNQILVITDGEPPKEGFQLCSRSNEILQKDDPQAPVDTRWTEVNSMREIDNIYDLGFWDNLREVFHMPIRRCVR
What is the function of this protein?
Palmitoyltransferase that targets several endosomal SNAREs.  Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain.  May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity).
What are the official names of this protein?
Palmitoyltransferase swf1.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PSAA_YERPS
Sequence: MKMKCFAKNALAVTTLMIAACGMANASTVINSKDVSGEVTVKQGNTFHVDFAPNTGEIFAGKQPGDVTMFTLTMGDTAPHGGWRLIPTGDSKGGYMISADGDYVGLYSYMMSWVGIDNNWYINDDSPKDIKDHLYVKAGTVLKPTTYKFTGRVEEYVF
What is the function of this protein?
Fibrillar structure, part of fimbriae, necessary for full virulence.
What are the official names of this protein?
pH 6 antigen, Adhesin, Antigen 4.
What are the subcellular locations of this protein?
Fimbrium.
Protein: RM08_YEAST
Sequence: MTVGIARKLSRDKAHRDALLKNLACQLFQHESIVSTHAKCKEASRVAERIITWTKRAITTSNSVAQAELKSQIQSQLFLAGDNRKLMKRLFSEIAPRYLERPGGYTRVLRLEPRANDSAPQSVLELVDSPVMSESHTVNRGNLKMWLLVKSVINDDANQLPHNPLTLQNLHKVAKFKAEAQLHGEIMLIKQVLLKEMSLPYDEALENERTQALLKEVYSSSLPKKTKKPSSYVMVPRP
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
54S ribosomal protein L8, mitochondrial, Mitochondrial large ribosomal subunit protein bL17m, YmL8.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Protein: APC11_ARATH
Sequence: MKVKILQWHAVASWTWDAQDETCGICRMAFDGCCPDCKLPGDDCPLIWGACNHAFHLHCILKWVNSQTSQAHCPMCRREWQFKE
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins.  The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation.  Involved in the control of endoreduplication.  May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).
What are the official names of this protein?
Anaphase-promoting complex subunit 11, Cyclosome subunit 11.
What is the protein family that this protein belongs to?
Belongs to the RING-box family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PLPP2_HUMAN
Sequence: MQRRWVFVLLDVLCLLVASLPFAILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVTITATVILVSAGEAYLVYTDRLYSRSDFNNYVAAVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLEKVCRGNPADVTEARLSFYSGHSSFGMYCMVFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQHCLKEEELERKPSLSLTLTLGEADHNHYGYPHSSS
What is the function of this protein?
Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9705349, PubMed:9607309, PubMed:16467304).  Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly (PubMed:16467304).  Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309).  Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (Probable).  Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity).
What are the official names of this protein?
Phospholipid phosphatase 2, Lipid phosphate phosphohydrolase 2, PAP2-gamma, PAP2-G, Phosphatidate phosphohydrolase type 2c, Phosphatidic acid phosphatase 2c, PAP-2c, PAP2c.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TMM51_MOUSE
Sequence: MMAQSKANGSHYALTAIGLGMLVLGVIMAMWNLVPGFSPADKPTSQGNKTEGGGGILKSKTFSVAYVLVGAGMMLLLLAICLSIRDKRRMRQSEELARIQQQAGTVPHSQEEDSQEEEEDVSSRYYVPSYEEVMNTGYPETRGQEQNPRLSISLPSYESLTGLDEATPTSTRAETETSPGHAPDRQNSKLAKRLKPLKVRRIKSEKLHLKDFRITLPDKNVPPPSIEPLTPPPLYDEVQAKAPDARPPD
What are the official names of this protein?
Transmembrane protein 51.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.