PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_STRPS
Sequence: MSRILDNEIMGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEAAKMRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNELEPGDVLFIDEIHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTRAGMLSNPLRARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPRIANRLLKRVRDFAQIVGNGVIDDVITDKALTMLDVDHEGLDYVDQKILRTMIEMYGGGPVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRSGRMATAKAYEHLGYEYNEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: IPYR_DEBHA
Sequence: MSFTARQIGAPNTLDYRVFIEQNGKPVSPFHDIPLYANEEKTVLNMIVEVPRWTNAKLEISKEEKLNPILQDTKKGKLRFVRNCFPHHGYIHNYGAFPQTWEDPNQVHPETKAKGDNDPLDVCEIGEQVGYVGQVKQVKVLGVMALLDEGETDWKIIVIDVNDPLASKLNDIEDVETHLPGLLRATNEWFRIYKIPDGKPENQFAFSGECKNKKYAEEIINECSEAWEKLIKGETADSKGISLDNTTLSSTQTFSEAAASGVPPASVQPAAPIDKSVDKWFFISGAH
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPI2_MYXVU
Sequence: MELFKHFLQSTASDVFVSPVSISAVLAVLLEGAKGRTAAQLRLALEPRYSHLDKVTVASRVYGDWRLDIKPKFMQAVRDRFELVNFNHSPEKIKDDINRWVAARTNNKILNAVNSISPDTKLLIVAAIYFEVAWRNQFVPDFTIEGEFWVTKDVSKTVRMMTLSDDFRFVDVRNEGIKMIELPYEYGYSMLVIIPDDLEQVERHLSLMKVISWLKMSTLRYVHLSFPKFKMETSYTLNEALATSGVTDIFAHPNFEDMTDDKNVAVSDIFHKAYIEVTEFGTTAASCTYGCVTDFGGTMDPVVLKVNKPFIFIIKHDDTFSLLFLGRVTSPNY
What is the function of this protein?
Weak inhibitor of the interleukin-1-beta converting enzyme (ICE) and of granzyme B.  Does not form a stable complex with ICE, but can for a stable complex with granzyme B.
What are the official names of this protein?
Serine proteinase inhibitor 2, Serp-2, Serpin-2.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Poxviruses subfamily.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: SLA_GLOBL
Sequence: MGRFIFVSFGLLVVFLSLSGAEDDSDCPSDWSSNGRFCYKLFQQKMKWADAERFCTEQRTGAHLVSIESNTEAAFVNQMISENIKKTDYVWIGLTVQNEEQQCKSRWSDRSSVSYENLVKPNSKKCFVLKEYEGSRKWFNVYCGQKYAFMCKFLRPR
What is the function of this protein?
Binds to platelet GPIbalpha (GP1BA) and enhances platelet aggregation at low-shear stress.  At high-shear stress, blocks platelet aggregation in a dose-dependent manner.
What are the official names of this protein?
Snaclec mamushigin subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: 5HT3C_HUMAN
Sequence: MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT
What is the function of this protein?
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.  This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses.  It is a cation-specific, but otherwise relatively nonselective, ion channel.
What are the official names of this protein?
5-hydroxytryptamine receptor 3C, 5-HT3-C, 5-HT3C, Serotonin receptor 3C.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
Protein: RLME_AGRFC
Sequence: MSKAPTSTNRTGRKIGQKVKKTKLKASSRRWLERHINDPYVQRAKLEGYRARAAFKLLEINDKHQILKGATRIIDLGAAPGSWSQIASKVTDSTEDDIRVAAIDFLEIDPIPGVKILQLDFLDPTAPDQLMEAVGGTPDLVLSDMAAPTTGHQKTDHIRTMHLCEVAADFAVQVLAEGGHFLAKTFQGGTEKALLDMLKKNFKQVLHIKPASSRSESVEMFLLAKHFKGRRHEPAIDADAEESTED
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_CHLPB
Sequence: MYSAKKILGLIGRNVGYSYSPYIHNTAAEKLGLGYYYTIFNISSHDLVPSALEGAKALGIAGFNVTIPYKKTVVACMDKLSPEAEAIGAVNTIVNDNGTLIGYNTDIAGIVIPLEPYASMIDAQPVGIFGNGGAAMAAIEALSTCFTPSGIRLFVRQREKGSELCRQFKDKNLPIPLSTHTLDDHTAQHNCRLLINATPIGTKGLDTAPAGSIIPSGSGVVHSGQIIFDMVYNPVETQLLQLAKATGAIAIPGIEMLIGQASRSFEIWTGKAMPVTTVRNKLQELLLTEKRSS
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: COBS_MYCVP
Sequence: MISSLTGAFAFATVLPTPTRATAMVGRGVLTALPVAGAALGVLAAGVLWAGSWAFGDGSALAGVLTVAVLLLATRGLHIDGLSDTVDALGCYGPPERALAVMRDGTAGPFGVAAVAATLLVQSLAFAQSGWAAVFIAVVAGRVAVVAACRRGVPAAAGSTLGALVSGTQPRWVAAGWTVAVAAAAVPVCARPWQGPLVVALALACSAGLVAHCVRRFGGITGDVLGAALEVTTTIAAVGLAVR
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEM1_SYNJB
Sequence: MFIAVVGLSHRTAPVEIRERLSIAEAEVGETIQQLRTHPHIEEAAILSTCNRLEVYIVTSEMESGVRQTMQFLAELKGIPLPQLRPHLFTLLYQDAVTHLMRVAAGLDSLVLGEGQILSQVKKAQQLGQACNGMDRILNRLFKAAITAGKRVRTETEIGTGAMSISSAAVELALQEQGSLSQGKVTVVGAGRMARLLVQHLLAKGAVDITVVNRSLERAEALAKQFEQPIQVLPWESLLNSVAESNLVFTSTGATQPILNYQQLAGVLQPDQPLLLVDISVPRNIDPDVEKLKGVQVFNVDHLSRIVEENRAQRQKLALAAEALVEEEVDQFMEWWRSLETVPTISSLRHKVESIREQEMEKALSRLGKDFAEKHLEVIDALTRGIVNKILHDPMVQLRAKRDIEARRAAMRILQELFNLDPVVFQAQQER
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: NUOH_PROMH
Sequence: MSWLSPEVTEILLTVLKAVVILLVVVTCGAFMSMGERRLLGLFQNRYGPNRVGYAGSAQLIADMIKMFFKEDWIPKFADRFIFTIAPVIAFSSLLLSFAIVPVSSTWVVADLNIGILFFLMVAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTVSYEVFLGLSILGVVAQAGSFNLTDIVNSQAHMWNIIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVAVSGLIVTLFFGGWQGPFLPSFVWFALKTGFFMMMFILIRASLPRPRYDQVMAFGWKICLPLTLINLLVTAAVILYNAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL33_CHLPD
Sequence: MAKGKENRIVITLECTEAKKEGKTVSRYTTTKNKKNTTERLLLKKYNPNLQRHTIHKEIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: YNFA_SALPA
Sequence: MLKTTLLFFVTALCEIIGCFLPWLWIKRGASVWWLLPAAASLALFVWLLTLHPAASGRVYAAYGGVYVCTALLWLRVVDGVRLTVYDWCGALIALCGMLIIVVGWGRT
What are the official names of this protein?
UPF0060 membrane protein YnfA.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSBA_VIBPA
Sequence: MSINTDETTWQTFKRLWQFIRLYKSGLIVAVIALVINAISDTYMISLLKPLLDEGFGNADSDFLRTLPLIIFVMMFIRGTSGFVSTYCLSWVSGNVVMLVRRMVFNHFMHMPVSYFDKEKTGNLLSRITYDSEQVSAATSQALVSIVREGASIIGLLVLMFYNSWQLSLVLFAVAPVVAWGIGVVSKRFRKISKNMQTMMGNVTASAEQMLKGHKVVLSYGGQDIERQRFDKVSNQMRQQSMKLVTAQAAANPIIQMIASFAIVAVLYLASIDSIKEQLTPGTFTVVFSAMFGLMRPLKALTNVTSQFQRGMAASQTLFALIDLEPEKNEGKYTVERAKGDVSVKDVSFTYVGSEKPALEHVSFDIPRGKTVALVGRSGSGKSTIANLFNRFYDVDSGSITLDGRDIRDYELKNLREQFALVSQNVHLFNDTIANNIAYATEDKYERSDIEHAAKLAHAMEFINKMENGLDTMIGENGASLSGGQRQRVAIARALLRDAPVLILDEATSALDTESERAIQAALDELQKDKTVLVIAHRLSTIEKADEILVVDDGAIIERGNHADLIAKNGAYAQLHRIQFGE
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ADSL3_ARATH
Sequence: MGDKNKDDSSSQSKAVRKEKRAFLFRKWTRVDVMRVSAVGAVHLLCLLAPFNYTWEAFRFAAMVGISTNLSITFSYHRNLTHRSFKLPKWLEYPFAYSALFALQGHPIDWVSTHRFHHQFTDSDRDPHSPIEGFWFSHVFWIFDTSYIREKCGGRDNVMDLKQQWFYRFLQNTIGLHILTFWILVYLWGGLPYLTWSVGVGGAIGYHATWLINSACHIWGSRAWNTKDTSRNIWWLGPFTMGESWHNNHHAFEASARHGLEWYQVDLTWYLIWFFQVLGLATDVKLPTDAQKRKMSLAR
What are the official names of this protein?
Delta-9 desaturase-like 3 protein.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ELOV1_MOUSE
Sequence: MEAVVNLYHELMKHADPRIQSYPLMGSPLLITSILLTYVYFILSLGPRIMANRKPFQLRGFMIVYNFSLVILSLYIVYEFLMSGWLSTYTWRCDPIDFSNSPEALRMVRVAWLFMLSKVIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGIKIAPGGMGSFHAMINSSVHVVMYLYYGLSALGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMPSCNYQYPIIIHLIWMYGTIFFILFSNFWYHSYTKGKRLPRAVQQNGAPATTKVKAN
What is the function of this protein?
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle.  This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.  Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA.  May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.  Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis.  Indirectly inhibits RPE65 via production of VLCFAs.
What are the official names of this protein?
Elongation of very long chain fatty acids protein 1, 3-keto acyl-CoA synthase Elovl1, ELOVL fatty acid elongase 1, ELOVL FA elongase 1, Very long chain 3-ketoacyl-CoA synthase 1, Very long chain 3-oxoacyl-CoA synthase 1.
What is the protein family that this protein belongs to?
Belongs to the ELO family. ELOVL1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MSRA_PAEAT
Sequence: MKTFVLGGGCFWCLDAVYQKTRGVSSVVSGYTGGHVRNPDYYEVCSGTTGHAEVVAVTFDETVVPEEVILDMFFALHDPTTLNRQGYDVGTQYRSSMFYTTTEEKVLFEEAIERAQALWSDPIVTEVSRLPEFHEAEEVHQNYYAKFPYQGYCQVIINPKLAKARKYYSAWLTA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: CD276_MOUSE
Sequence: MLRGWGGPSVGVCVRTALGVLCLCLTGAVEVQVSEDPVVALVDTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYSNRTALFPDLLVQGNASLRLQRVRVTDEGSYTCFVSIQDFDSAAVSLQVAAPYSKPSMTLEPNKDLRPGNMVTITCSSYQGYPEAEVFWKDGQGVPLTGNVTTSQMANERGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPLTFPPEALWVTVGLSVCLVVLLVALAFVCWRKIKQSCEEENAGAEDQDGDGEGSKTALRPLKPSENKEDDGQEIA
What is the function of this protein?
Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection.  Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface.  Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells.
What are the official names of this protein?
CD276 antigen, B7 homolog 3, B7-H3, Costimulatory molecule.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. BTN/MOG family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TRUC_SALTI
Sequence: MLEILYQDPWLVAVNKPAGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRRLAQQFEQHHIRKRYHAIVRGWLIDDAVLDYPLVEERDKIADKFAREDKAPQPAVTQYRGLATVEMAVPTGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSAAEHFACRRLMLHASRLELTHPFTGQPLIIQAGLDETWMQVLTQFGWRGLLPDNERVEFTAASRQDETHLT
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase C, tRNA pseudouridine(65) synthase, tRNA pseudouridylate synthase C, tRNA-uridine isomerase C.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: FIM1F_PARD8
Sequence: MRFNVVLFMLIVALLGGLSTCSSEVPIGFDTDELSFDMSLVLLTGDMQTKASDPNYTYATTEELTIQNCHVAVFDKDGKRIYFKNFYSKDLGEMKTIGNLSGYELQLEGVRTFGKEDKKVSVLVVANANNANNSPFDNLTTYDGVDNSYTAKTIAKGPVTASLLVKIGKSETTLKYNQDNAPVTVSLIQLSAKIEYTGVYKKENGELLEGFSLTKVAGLNASSKITIFNTSAVENGAFSDLAYPTTKPVTFYTYEISDAFKEVILSVQSGVEPKEYPFPANKFIKGNYYRIKGLKSSTEIEWVLENVEDKEVTLDPFE
What is the function of this protein?
Putative component of the fimbrium tip.  Fimbriae are filamentous appendages on the cell surface that mediate cell adhesion and biofilm formation.
What are the official names of this protein?
Putative fimbrium tip subunit Fim1F.
What is the protein family that this protein belongs to?
Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: VP4_ROTSF
Sequence: MAALIYRQLLTNSYTVELSDEIQEIGSTKTQNVTVNPGPFAQTNYAPVNWGPGETNDSTTVEPVLDGPYQPTTFNPPVSYWMLLAPTNAGVVVEGTNNTNRWLATILIEPNVQQVERTYTLFGQQVQVTVSNDSQTKWKFVDLSKQTQDGNYSQHGSLLSTPKLYGVMKHGGKIYTYNGETPNANTGYYSTTNFDTVNMTAYCDFYIIPLAQEAKCTEYINNGLPPIQNTRNIVPVSIVSRNIVYTRAQPNQDIVVSKTSLWKEMQYNRDIVIRFKFANSIIKSGGLGYKWSEVSFKPANYQYTYTRDGEEVTAHTTCSVNGVNDFNYNGGSLPTDFVISKYEVIKENSFVYIDYWDDSQAFRNMVYVRSLAADLNSVMCTGGDYSFALPVGNYPVMTGGAVSLHSAGVTLSTQFTDFVSLNSLRFRFRLSVEEPPFSILRTRVSGLYGLPAAKPNNSQEYYEIAGRFSLISLVPLNDDYQTPIMNSVTVRQDLERQLGELRDEFNNLSQQIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSMATNVMKRFKKSSLANSVSTLTDSLSDAASSISRSASVRSVSSTASAWTEVSNIASDINVTTSSISTQTSTISRRLRLKEMATQTDGMNFDDISAAVLKTKIDKSTQLNTNTLPEIVTEASEKFIPNRAYRVIKDDEVLEASIDGKYFAYKVETFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYGISRQQALNLLRSDPRVLREFINQDNPIIRNRIESLIMQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: ACT_CROSI
Sequence: VAPEEHPVLLTEAPLNPK
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.
What are the official names of this protein?
Actin homolog, Peptide 3.
What is the protein family that this protein belongs to?
Belongs to the actin family.
Protein: PDXT_THEFY
Sequence: MSSVPPTIGVLALQGDVREHIHALEQAGARARRIRRPDELDSIDGLILPGGESTTMGRLAAVFGLLTPLRERIAAGLPAYGTCAGMIMLADRLADGAPGQQTIGGIDMTVRRNAFGRQVASFEGTVEMTGVDGGPVEAVFIRAPWVESTGPGVQVLGRISRGDTAGRIVAVRQGRLLATSFHPELTGDTRVHRLFVDMVKG
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: Y2941_TOLAT
Sequence: MKLIVVSGRSGSGKTVALRVLEDLGYYCVDNLPVSLLFQLVAELRGKYDQIAVSIDVRNLPATAEDLVSILDEIRQHQDLQFSSFFFDADNATLLKRYGESRRLHPLSRQQFTLAQAIRQETDLLSPLSSSADLRIDTSHISIHELSEQIRERVLGKKEHELVMVFESFGFKHGIAKDADFVFDARFLPNPHWIAELKPLTGLDEPVQRYLQSQPDVVKYINQLISLLETWLPQLERNNRSYVTVAIGCTGGQHRSVFIAEQLANHFLVLGKNVQRRHRTLEKLHAPG
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Tola_2941.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: ACTP_SALDC
Sequence: MKRVLTALAAALPFAAHAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRSDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAMAVHPKGTAIMSPGGLVQDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAYKDAAGALIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFRKGATEREELKVSKITVLVLGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMLGGWLGLLTAVVLMILGPTIWVQILGHEKAIFPYEYPALFSISVAFLGIWFFSATDNSAEGNREREQFRAQFIRSQTGFGVEQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NU3C_SACHY
Sequence: MFLLHEYDIFWTFLIIASLIPILVFWISGLLAPVSEGPEKLSSYESGIEPMGGAWLQFRIRYYMFALVFVVFDVETVFLYPWAMSFDVLGVSVFIEAFIFVLILVVGLVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.