PharMolix/UniProtQA huggingface dataset:
Protein: PMRA_PSEAE
Sequence: MRILLAEDDLLLGDGIRAGLRLEGDTVEWVTDGVAAENALVTDEFDLLVLDIGLPRRSGLDILRNLRHQGLLTPVLLLTARDKVADRVAGLDSGADDYLTKPFDLDELQARVRALTRRTTGRALPQLVHGELRLDPATHQVTLSGQAVELAPREYALLRLLLENSGKVLSRNQLEQSLYGWSGDVESNAIEVHVHHLRRKLGNQLIRTVRGIGYGIDQPAP
What is the function of this protein?
Member of the two-component regulatory system PmrA/PmrB that plays a role in the regulation of resistance towards polymyxin B and cationic antimicrobial peptides in response to limiting concentrations of Mg(2+) (PubMed:14507375).  Functions as a transcriptional activator by direct binding to a cis-acting sequence upstream of the target gene promoters including lipase lipA and pmrH promoters (PubMed:16707691, PubMed:29379484).  Autoregulates also its own pmrAB operon under Mg(2+)-limiting conditions (PubMed:14507375, PubMed:16707691).
What are the official names of this protein?
Response regulator protein PmrA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_STAAE
Sequence: MTKPIVAIVGRPNVGKSTIFNRIVGERVSIVEDTPGVTRDRIYSSGEWLTHDFNIIDTGGIEIGDAPFQTQIRAQAEIAIDEADVIIFMVNVREGLTQSDEMVAQILYKSKKPVVLAVNKVDNMEMRTDVYDFYSLGFGEPYPISGSHGLGLGDLLDAVVSHFGEEEEDPYDEDTIRLSIIGRPNVGKSSLVNAILGEDRVIVSNVAGTTRDAIDTEYSYDGQDYVLIDTAGMRKKGKVYESTEKYSVLRALKAIERSNVVLVVIDAEQGIIEQDKRVAGYAHEQGKAVVIVVNKWDTVEKDSKTMKKFEDEVRKEFQFLDYAQIAFVSAKERTRLRTLFPYINEASENHKKRVQSSTLNEVVTDAISMNPTPTDKGRRLNVFYATQVAIEPPTFVVFVNDVELMHFSYKRYLENQIRAAFGFEGTPIHIIARKRN
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: FABH_STRTD
Sequence: MAFAKISQVAHYAPAQVVTNDDLSKIMDTSDEWIRSRTGIQERRISLNENTSDLATNVAYQLLEKSGLSPEELDFVLVATISPDNSMPSVAARVQGTIGAVNAFAFDITAACSGFVFALATAEKLIKSGAYKKGLVIGAEVLSKTLDWSDRATAVLFGDGAGGVLLEESEEEHFFGESLNTDGSKGGLESGASAVISPYSDGTEQPNPYMQMDGKAIFDFAVKTVSKSIKALVEEKGEPDYFLLHQANIRILDTMAKKIDVSRDKFLANMMSYGNTSAASIPILLSENVANETLKLGSDQTILLSGFGGGLTWGSLIVKI
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUST_ASPCI
Sequence: MVDKSNKVALVLGATGISGWALAKNALSYPSRSTFQRVIGLMHRPRTVEETGLPNDPRLELYSGVDLQGDLNHVVVKLKEKIPRIEEVTHVYYLAYMTLQTCSGDMRQFRDANVAMTYTAVHACDRLCPNMEFFVLQTGTNAYGVACFDYLRQTQLQVPLRESNPRVPRPWSDTLFYYAQADLIKEANKGKAWKWCEVRPDQIVGHTPAQVSVPYVAPMALYLALYRYINGPGARVQFPGTVRNYHHTYTDVRPDTMARAELYLSLVKSDESHGEAFNIADTDTPGPWSAKWPSICRYFGLEASETIDDEWTDIDGWWYANQTAYERMCAEYGLQKQVMSPTAWSLMKMGHTLIDQNRELCLDKIRGLGFTEDHPVGSSYFQVFEDFERMKIIPPKVVLASPRCRDVLHQC
What is the function of this protein?
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of calidodehydroaustin, a fungal meroterpenoid (PubMed:28233494, PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:28233494).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:28233494).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:28233494).  The cytochrome P450 monooxygenase ausR then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:28233494).  The hydroxylation catalyzed by ausR permits the O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:28233494).  The short chain dehydrogenase ausT catalyzes the reduction of the double bond present between carbon atoms 1 and 2 to convert 7-dehydrodehydroaustin into 1,2-dihydro-7-hydroxydehydroaustin (PubMed:28233494).  AusQ catalyzes not only an acetylation reaction but also the addition of the PKS ausV diketide product to 1,2-dihydro-7-hydroxydehydroaustin, forming precalidodehydroaustin (PubMed:28233494).  Finally, the iron/alpha-ketoglutarate-dependent dioxygenase converts precalidodehydroaustin into calidodehydroaustin (PubMed:28233494).
What are the official names of this protein?
Short chain dehydrogenase ausT, Austinoid biosynthesis cluster protein T.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: YEJB_ECO57
Sequence: MGAYLIRRLLLVIPTLWAIITINFFIVQIAPGGPVDQAIAAIEFGNAGVLPGAGGEGVRASHAQTGVGNISDSNYRGGRGLDPEVIAEITHRYGFDKPIHERYFKMLWDYIRFDFGDSLFRSASVLTLIKDSLPVSITLGLWSTLIIYLVSIPLGIRKAVYNGSRFDVWSSAFIIIGYAIPAFLFAILLIVFFAGGSYFDLFPLRGLVSANFDSLPWYQKITDYLWHITLPVLATVIGGFAALTMLTKNSFLDEVRKQYVVTARAKGVSEKNILWKHVFRNAMLLVIAGFPATFISMFFTGSLLIEVMFSLNGLGLLGYEATVSRDYPVMFGTLYIFTLIGLLLNIVSDISYTLVDPRIDFEGR
What is the function of this protein?
Probably part of a binding-protein-dependent transport system.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Inner membrane ABC transporter permease protein YejB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AMEL_PIG
Sequence: MGTWILFACLLGAAFSMPLPPHPGHPGYINFSYEVLTPLKWYQNMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQSHALQPHHHIPMVPAQQPGIPQQPMMPLPGQHSMTPTQHHQPNLPLPAQQPFQPQPVQPQPHQPLQPQSPMHPIQPLLPQPPLPPMFSMQSLLPDLPLEAWPATDKTKREEVD
What is the function of this protein?
Plays a role in the biomineralization of teeth.  Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development.  Thought to play a major role in the structural organization and mineralization of developing enamel.
What are the official names of this protein?
Amelogenin, Amelogenin 173A/173B, Leucine-rich amelogenin peptide, LRAP.
What is the protein family that this protein belongs to?
Belongs to the amelogenin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PSBJ_DIOEL
Sequence: MADTTGRIPLWLIGTVTGIPVIGSIGIFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: LPXA_VARPS
Sequence: MTQVHPTALVDPKAQLDASVSVGPYTVIGPHVRVGAGTTIGAHCVIEGRTTIGRDNRIFQFSSLGAIPQDKKYAGEPTELVIGDRNVIREFCTFNLGVPGAGGVTTVGNDNWIMAYTHIAHDCHVDNHTTLANNTTLAGHVHLADWVTIGGLTGIHQFVSVGAHAMVGFASAVSQDVPPFMLVDGNPLAVRGFNVVGLRRRDFSAPRLAAVKQMHRLLYRQGKTLEEARAGIAALATEMPEAAADVALMEQFLATSTRGIAR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_SACD2
Sequence: MALVIGVTGGIGSGKTTVTNMFEPLGIEVVDTDLIAREVVQPQQPCLEAITQRYGPQILLADGNLNRKKLRDIVFADNSERLWLESVTHPAIRQLTVQRLRAAKSPYVILSSPLLLETDQYTLTDKIVAVDVDEAQQVERASARDGQSVEQIQAIMQKQITRQARLAKADYVIDNSHTLEHTHSQVQALHQTFTMLATAIEQK
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EVA1C_MOUSE
Sequence: MLLPGHPRPPPAPQSAQNQGLRRQVEPPGQLLRLFYCTVLVCSKETSALTDFSGYLTKLLQNHTAYACDGDYLNLQCPRHSTISVQSAFYGQDYQMCSSQEPISQREDNLTCVASTTLQKVLDECQNQRACHLLVNSRVFGPDLCPGSSKYLLVSFKCQPNELKNKTVCENQELKLHCHESKFLNIYSAAYGRRTQQRDICSSGAELLPPFDCLSYTALQVLSRRCYGKQRCKVLVDNYHFGSPCLPGVKKYLTVAYACVPKNILTAVDPAVANLNPSLKKDDEHGITFNPSGSRVVRKDGVIVSNSLAAFAYIRAHPERAALLFMSSVCIGLLLTLCALVIRVSCTKDFRELRQGREHLVLGSDKAEEDSEEDLEEEDSSDSQFPEELSRFCRTSYPAYSSIEAAELAERIERREQVIQEIWMNSGLDSSLPRNVGHFY
What is the function of this protein?
Binds heparin.
What are the official names of this protein?
Protein eva-1 homolog C, Protein FAM176C.
What is the protein family that this protein belongs to?
Belongs to the EVA1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: FLIE_PECCP
Sequence: MSVQGIDGVLQQMQVKALQASGTPIARPSVEPGFASELKAAIDKISDTQQTARTQAEKFTLGVPGVALNDVMVDLQKSSISMQMGIQVRNKLVSAYQEVMNMSV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: Y620_YERPN
Sequence: MNNPDDVLLINRFLRQQHVLTLCAGSGMDMWCASCFYVFDENQMALFLMTEKHTRHSELMLINPQVAGTVATQSRTIALIKGIQYRGEISLLSGDAEQAARNRYCRRFPVAKVSSAPLWQLNLLEIKMTNNALGFGKKLHWSRVEPL
What are the official names of this protein?
UPF0306 protein YPN_0620.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: NANM_BRUO2
Sequence: MFSLIGAKRLAIGIAALAWSTGAVMASEHWPDLPVGIKNGAAARIGNMAYVGLGSAGTDFYALDLNNPSKGWVKRANFIGPATNGAAMAAAGGKIFAFSGNGKATPDAKSPIIFDTAYVYDPGSDGWSKLDTQTPVGLSGAKAVGLADGRIAIFGGYNKELFDKYLADVGAIDKDKEPEAYRKLVDSYMGMKPEAYRWNDEVLVYDPAGNNWGSLGANPFLPNCDPAMATMGEGDFLLVSGEIKPGLRTPEAKLVKIRDGAAHWQKVSDLPPLSGSEPQEGVAGAYAGKAGDDVLVAGGANFKGAQANAAAGKWFAHDGLAKSWRDDVYAFDGKDWKVAGKLPRGLAYGAAFDAPGGLLVVGGEDRDGKARKEVFLLKWDGKALSVEN
What is the function of this protein?
Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers.  Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer.  In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
What are the official names of this protein?
N-acetylneuraminate epimerase, N-acetylneuraminate mutarotase, Neu5Ac mutarotase, Sialic acid epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanM family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DAPB_MAGO7
Sequence: MPVDKKSGNGRPSLDSVSSISTTSIVFDHLNDLEIHKKHRPHLMTESIRRDDHLSDFDDDDPLKQEMDGEGDLETGPFLAGRDAYTFGGGKYMDRKFRRIMIVVAGLLVAAWVGGLFVYIASKSYKHATTVEHDPEKTKAAALTSGKKITMDQVRSGTWYAASHDITWIAGPKGEDGLMIEVGADGKDYIVIEDGRAENPDSSAEAEVDVTASRRTLMKNGSFRYQGRMHIPSGAEPSRDQQKVLLRTEQKSNWRHSHTACYWIWDVATETAEPLIPASPDARVQNAQWSPTSDAIVFTRENNLYLRTIGSKKVTQITKDGGADLFYGVPDWVYEEEVIAGASTTWWSEDGKYVAFLRTNETGVPAFPVQYFMSRPSGASPKAGEETYPEVRDIKYPRSGSHNPVVDVQFYDIARGDVFTVDINGGFADEDRLITTVLWAGSQVIVKETNRVSDIMRVVLIDVKKRTGKTTRTVDVGKIDGGWFEISQNTKYIPADPKKGRDQDGYIDTVIHNDGDHLAYFSPPDNPDPIMLTSGPGWEVVDAPSAVDLENNLVYFIATKEGSTQRHVYSVQLDGKNMKSFTDTEAKGYYDVSFSSGAGYALLSYKGPKIPWQKVVSTPANNQRYEVLIEENKELAESARKYDLPLLNYGTLNVEGVELNYLERRPPQFSEKKKYPVLFHQYSGPGSQSVSQKFSVDFQSYVAASLGYIVVTFDGRGTGFIGRKNRVLVRSRLGEIEAQDQIAAAKHWASLGYVDPSRIAIWGWSYGGFQTLKTLEADAGRTFSYGMAVAPVTDWRFYDSIYTERYMLTPQQNEDGYTKSAVHNVSALASNKRFLLMHGASDDNVHFQNSLTLLDKLDMGAVENYDVHVFPDSDHSIFFHNANKIIYDKLENWLVNAFNGEWLKVNNAKPVELVHPTQLVREREKAKLRKRWQEIQNK
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Probable dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: MNN9_CANAL
Sequence: MVHYRNRYLNYIRRKPLALLAPITLLVVIYFYFFSAHGFSSNKQKYNYNKKSRGWFYKNRDTVILKDLPKNHISHYDLNKLTASKDALNKREEVLILTPMSKFLPEYWENINKLTYDHSLISLGFIFPRTTQGDDALKELENALKKTKREKRLNFKKITILRQDSNSLQSQLEKDRHAFKVQKERRSMMALARNSLVFSTILPSTSWVLWLDADIVETPVTLIQDLTGHNKPVVSANVHQRFINQDTKQPDIRPYDFNNWVESEEGLKLAASLPDDEIIVEGYSEMVTHRALMAHFYDPKGDPSTEMTLDGVGGGAVMVKADVHRDGAMFPSFPFYHLIETEGFAKMAKRLGYEVYGLPNYLVFHYNE
What is the function of this protein?
Required for the addition of the long alpha 1,6-mannose backbone of N-linked glycans on cell wall and periplasmic proteins.
What are the official names of this protein?
Mannan polymerase complex subunit MNN9.
What is the protein family that this protein belongs to?
Belongs to the ANP1/MMN9/VAN1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: TPSN_CHLAE
Sequence: MKSLSLLLAVALGLATAVSAGPAVIECWFVEDTSGKGLAKRPGALLLRQGQGEPPPRPDLDPELYLNVHDPTGFLQAAFRRYPRDAPAPHCEMSRFVPLPASANWASGLTPARNCPRALDGAWLMVSMSSPVLSLSSLLRPQPEPQQEPVLITMATVVLTVLTHTPAPRVRLGQDALLDLSFAYMPPTSEAASSLAAGPPPFGLEWRRQHLGKGHLLLAATPGLNGQMPAAQEGAVAFAAWDDDEPWGPWTGNGTFWLPRVQPFQEGTYLATIHLPYLQGQVTLELAVYKPPKVSLMPATLAWAAPGEAPPELLCLVSHFYPPGGLEVEWELRGGPGGRSQKAEGQRWLSALRHHSDGSVSLSGHLQPPPVTTEQHGARYACRIHHPSLPASGRSAEVTLEVAGLSGPSLEDSIGLFLSAFFLLGLFKALGWAAVYLSTCKDSKKKAE
What is the function of this protein?
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
What are the official names of this protein?
Tapasin, TPN, TPSN, TAP-binding protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: NORW_ECO55
Sequence: MSNGIVIIGSGFAARQLVKNIRKQDATIPLTLIAADSMDEYNKPDLSHVISQGQRADDLTRQTAGEFAEQFNLHLFPQTWVTDIDAEARVVKSQNNQWQYDKLVLATGASAFVPPVPGRELMLTLNSQQEYRACETQLRDARRVLIVGGGLIGSELAMDFCRAGKAVTLIDNAASILASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGILATLDRQRSIEVDAVIAATGLRPETALARRAGLTINRGVCVDSYLQTSNADIYALGDCAEINGQVLPFLQPIQLSAMVLAKNLLGNNTPLKLPAMLVKIKTPELPLHLAGETQRQDLRWQINTERQGMVARGVDDADQLRAFVVSEDRMKEAFGLLKTLPM
What is the function of this protein?
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase.  Reduces the rubredoxin moiety of NO reductase.
What are the official names of this protein?
Nitric oxide reductase FlRd-NAD(+) reductase, Flavorubredoxin reductase, FlRd-reductase, FlavoRb reductase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_PSEAE
Sequence: MSQDIHAHRILILDFGSQYTQLIARRVREIGVYCEIHPFDMSNEAIIAFAPRGIILAGGPESVHEADSPRAPQAVFDLKVPLFGICYGMQTMAEQMGGKVQGSDLREFGYARVDVVGKARLLDGIEDHVDDDGVLGLDVWMSHGDKVTEMPAGFHILASTPSCPIAAMADDARAYYGVQFHPEVTHTKQGLRILSRFVLDICGCAALWTPSNIVDDAIATVRAQVGSSKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMAMFAENMGVKVIRANAEDKFLGRLAGVADPEEKRKIIGRTFIEVFDEEATKLQDVKFLAQGTIYPDVIESAGAKTGKAHVIKSHHNVGGLPEDMQFELVEPLRELFKDEVRKIGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEYADLLRQADHIFIEELRAFDWYHKTSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDFMTARWAHLPYELLEKVSNRIINEIAGISRVTYDVSSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PRIO_MESAU
Sequence: MANLSYWLLALFVAMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGTWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHNQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPMMHFGNDWEDRYYRENMNRYPNQVYYRPVDQYNNQNNFVHDCVNITIKQHTVTTTTKGENFTETDIKIMERVVEQMCTTQYQKESQAYYDGRRSSAVLFSSPPVILLISFLIFLMVG
What is the function of this protein?
Its primary physiological function is unclear.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: PCKA2_UROPA
Sequence: MASPNGGVTTYDYHDSDSAAPVNAQTIEELHSLQRKAATTTKDGASPLQSISASLASLAREYGPNLVKGDPEATKGAPPVPIKHQQPSAAAATIAASDSSLKFTHVLYNLSPAELYEQAFGQKKSSFITSTGALATLSGAKTGRSPRDKRVVKDETTSQELWWGKGSPNIEMDERQFVINRERALDYLNSLDKVYVNDQFLNWDSENRIKVRIITSRAYHALFMHNMCIRPTEEELESFGTPDFTIYNAGEFPANRYANYMTSSTSINISLARREMVILGTQYAGEMKKGLFGVMHYLMPKRGILSLHSGCNMGKEGDVALFFGLSGTGKTTLSTDHNRLLIGDDEHCWSDNGVSNIEGGCYAKCIDLSQEKEPDIWNAIKFGTVLENVVFNERTREVDYADKSITENTRAAYPIEFIPNAKIPCVGPHPKNVILLACDAYGVLPPVSKLNLAQTMYHFISGYTAIVAGTEDGVKEPTATFSACFGAAFIMYHPTKYAAMLAEKMQKYGATGWLVNTGWSGGRYGVGNRIKLPYTRKIIDAIHSGELLNASYKKTEVFGLEIPTAINGVPSEILGPVNTWTDKAAYKETLLKLAGLFKNNFEVFASYKIGNNNSLTEQILAAAPNF
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP) 2.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4C_PSINU
Sequence: MSNLPWLTLIVLFPFSASFLIPLLPYKGNKVVRWYTLGICALEFLLITFTFCCQFHLSDPSIQLKEDYNWISFLYFHWNLGVDGLSMGLILLTGFITTLAILAAWPVTRNVRLFYFLMLAMYSGQIGLFASQNILLFFFMWELELIPVYLLLSMWGGKKRLYSSTKFLLYTAGGSIFLLVGSLTMGLYGSNGTSFDLQILTNRSYPIAVETALYFSFLIAYAVKLPILPFHTWLPDTHGEAHYSTCMLLAGILLKMGGYGLIRINMELLPHAHFLFSPLLVTMGAVQIAYASLISFSLPNIKRRIAYSSVSHMGFVIIGISSITDIGTNGAILQMISHGLIGAALFFLAGISYDRTQTLYLDQLGGIAVPMPRLFTMFSFFSLASLALPGMSSFVAEFLIFLGIVTNPYYSLIFKSIILFIGAIGVILTPIYLLSMLRKMFYGFKIYQNSLFFIDLGPREIFISVFILLPILGIGIYPNLVLSLWNEKVESILLQYYG
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y3354_BACCN
Sequence: MKMTNKKMKKELMERLARPEWEFHYDSEKDVLRIEQKDTKKGINVSLPGVVAKWEVKKEAAIEDVVYYVTEALLAMHKEENQSGKIFPVIRSTSFPKEAEEGNPFIMTEHTAETRIYYALDSNKTYRLIDERLLQKLGLTEQQVREMALFNVRSLNYEFKQDQVAGNTFYFLNTNDGYDASRILNESLLQSMREKISGDMVVAVPHQDVLIIADIMNEIGYDIIAQMTMKFFAEGHVPITSLSFIYEDGEFEPIFILAKNRKKTNGKEKG
What are the official names of this protein?
UPF0354 protein Bcer98_3354.
What is the protein family that this protein belongs to?
Belongs to the UPF0354 family.
Protein: EF1B2_BOMMO
Sequence: MAVGDVKTAQGLNDLNQYLAEKSYVSGYTPSQADVQVFEQVGKAPAANLPHVLRWYNQIASYTSAERKTWSQGTSPLTAGAKPTAPAPAAKDDDDDDVDLFGSGDEEEDAEAERIREERLKAYADKKSKKPALIAKSSILLDVKPWDDETDMKEMENQVRTIEMEGLLWGASKLVPVGYGINKLQIMCVIEDDKVSVDLLTEKIQEFEDFVQSVDIAAFNKI
What is the function of this protein?
EF-1-beta and EF-1-beta' stimulate the exchange of GDP bound to EF-1-alpha to GTP.
What are the official names of this protein?
Elongation factor 1-beta'.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: HEM2_HELPJ
Sequence: MFKRLRRLRSSENLRAMVRETRLNINDFIAPLFVIESDSGIKNEISSMPGVYQMSIEPLLKECEELVGLGIKAVLLFGIPKHKDATGSHALNKDHIVAKATREIKKRFKDLIVIADLCFCEYTDHGHCGILENASVSNDKTLKILNLQGLILAESGVDILAPSNMMDGNVLSLRKALDKAGYFHTPIMSYSTKFASSYYGPFRDVANSPPSFGDRKSYQMDYANQKEALLESLEDEKQGADILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCFKRAGADMIISYHAKEVANLLQRN
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALAD, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: PYRB_BRUAB
Sequence: MTNQTVSPLFPHRHLLGIKGLSPLDILCLLDLADQEIAVSRQPEKKKSVLRGRTQINLFFEASTRTQSSFELAGKRLGADVMNMSVGNSSVKKGETLIDTAMTLNAMQPDILVIRHASAGAAALLAQKVGCSVVNAGDGAHEHPTQALLDALTIRRAKGQIENLIVAICGDVLHSRVARSNILLLNALGARVRVVAPSTLLPAGMADMSVEVFNSMEEGLKDADVVMMLRLQRERMAGSFVPSVREYFHFYGLDREKLKFAKPDALVMHPGPMNRGVEIASDVADGPQSVIQQQVEMGVAVRMAVMEALLDPRRNPGNGEPA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: TRMN6_ECO7I
Sequence: MSQSTFVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTDDSVMIDAVELESEAAAQAQENINQSPWAERINVHTADIQQWITQQTVRFDLIISNPPYYQQGVECSTPQREQARYTTTLDHPSLLTCAAECITEEGFFCVVLPEQIGNGFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQNYSEAYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.