PharMolix/UniProtQA huggingface dataset:
Protein: Y2570_MYCTU
Sequence: MATWDDVARIVGGLPLTAEQAPHDWRVGRKLLAWERPLRKSDREALTRAGSEPPSGDIVGVRVSDEGVKFALIADEPGVYFTTPHFDGYPAVLVRLAEIEVRDLEELITEAWLMQAPKQLVQAFLANSG
What are the official names of this protein?
Uncharacterized protein Rv2570.
Protein: Y8502_DICDI
Sequence: MLFKSLQSIVSSSSSTNSKVQIENQTSLGMKSFNKVSLLDHLSIFNGNKNNSLDLL
What are the official names of this protein?
Putative uncharacterized protein DDB_G0280433.
Protein: SYD_ONYPE
Sequence: MKTKYSHYNNQLQLAHQGKTVFLKGFIFRKRNLGKTLFFDLRDVSGIVQLLVKENNPQYDKIALIKLETVVQIKGQVIERINKNPDLPTGDIEILVSHIEILSEAQTLPLNVFQSQESLEETRLKYRYLDLRNPEVKHFLIQRHHITQSIRQTLLKNDFLELETLILSKSTPEGARDYLVPSRIYPGNFYALPQSPQLFKQLYMIAGFERYFQVARCFRDEDLRSDRQPEFSQIDIETSFLNQDEIMSLTEEIIVDLFANIWKKPLSQPFLRLTYQQAFELYGSDKPDLRNPLKITDFTTFFDTTTCPQNMFSGNIKGFKVSKTAVLTRRKLDEYQLFFSKHFNLKLFSFVKKNDKIIGGISQFIKDDSFLKNEEICFVVSGTKDIMHKALGIFRTKLALDLSLVDTTQEALLWIVDFPLFETTQEDLPQPDLTLENSNTSNRLYSLHHPFTAPCDIAILKSNPQKALAKTYDLVWNGYEVGGGSLRINNPQTQELIFSLLGFSQEEVQTRFGFLVEALKYGTPPHGGLALGLDRLVMLFTKTNNIKDVIAFPKTQSAKDLMLEAPSAVDQEQLNTLKLKFKCNCN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESF2_CHAGB
Sequence: MSTDKRNQFLDAGDSEDDAGHGYDSEEDLQKGGRSAKRRRVDDDDSDAEDVSDQEEEHGEDGATNLREGTADSEAARDDEEIAEEGPKDDKADLPAELPGVSKPLAKKNLVASEAAIKKSGVVYLSRIPPFMKPAKLRSLLEPYGKINRIFLTPEDPTEHTRRVRNGGNKKRSFTEGWVEFVKKKDAKKVCDLLNAQTIGGKKSSWYHDDVWALKYLNGFKWHHLTEQISAENAERTSRIRAEVAKTTRENKEFVRNVERAKVINGIQSKAAAKRKKTDDSEEAAGSGEAVGKTEGESAQDKRRTFKQILLAKKRKHEEQPAHVLRVLSKIF
What is the function of this protein?
Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis.  Required for the early cleavages at sites A0, A1 and A2 (By similarity).
What are the official names of this protein?
Pre-rRNA-processing protein ESF2, 18S rRNA factor 2.
What is the protein family that this protein belongs to?
Belongs to the ESF2/ABP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GCST_BACC4
Sequence: MITLQRTPLFDVYAKYGGKTIDFGGWELPVQFSSIKEEHEAVRTAAGLFDVSHMGEVEVKGVDSLAFLQRVVTNDVSTLKVGGAQYTAMCYENGGTVDDLLIYKRGEEDYLLVINASNIEKDYEWLASHVIGDATVVNVSSEVAQLAIQGPKAEGILQKVVSEDLKEIKFFKFKKDILVDGIPALVSRTGYTGEDGFEIYCKSEDAAKLWEKLLEVGAEEGLKACGLGARDTLRFEATLPLYGQELSKDITPIEAGIGFAVKTNKEADFFGKATLKEQKENGAPRKLVGIEVIERGIPRTHYPVFIGEEKIGEVTSGTQSPTLKKSIGLALIDVKYAAVDTEVEIEIRNKRVKAVVVPTPFYKRSK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: PYRB_BRUA1
Sequence: MTNQTVSPLFPHRHLLGIKGLSPLDILCLLDLADQEIAVSRQPEKKKSVLRGRTQINLFFEASTRTQSSFELAGKRLGADVMNMSVGNSSVKKGETLIDTAMTLNAMQPDILVIRHASAGAAALLAQKVGCSVVNAGDGAHEHPTQALLDALTIRRAKGQIENLIVAICGDVLHSRVARSNILLLNALGARVRVVAPSTLLPAGMADMSVEVFNSMEEGLKDADVVMMLRLQRERMAGSFVPSVREYFHFYGLDREKLKFAKPDALVMHPGPMNRGVEIASDVADGPQSVIQQQVEMGVAVRMAVMEALLDPRRNPGNGEPA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: TAM41_DICDI
Sequence: MIRNLTLLSKSSLDPKCLILKHSNKNLNNYFKQITFRYYSKTNPIIKQQNHNNINNYNNTTPETQERINELLKLFPPIKYGFAYGSGVISQKGYNRNGDGSTSTENPSKKEEQSPMIDLIFAVENSTKWHSLNLVNNQSHYSFLGLMGAHIVAKVQYMNAKIYFNTLLEHNGIKFKYGVIEYKDLIDDLKNWKTLYLSGRMQKPIFNLPTSSTEGLKEIQEINSEYNLKNAVITSLLMLPETFTEYDLYHTISKLSYSGDIRMKGAENPMKTHNIVINNIDGFRSLYFPIINDHLTQYLNVILENGDEVNSSLILSQNNNNKNNNKNETTTTAAPKMVTFKSKQDPMNYLNLLMMLPGSIKSTMLKEVRNNMKLMKSDEKIDPTILHNLIFMIVSKSSFAQTVKGVFTAGISKSLNYMKLKLKKNKK
What is the function of this protein?
Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane.  Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
What are the official names of this protein?
Phosphatidate cytidylyltransferase, mitochondrial, CDP-diacylglycerol synthase, CDP-DAG synthase, Mitochondrial translocator assembly and maintenance protein 41 homolog, TAM41.
What is the protein family that this protein belongs to?
Belongs to the TAM41 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: PCKA_BACC2
Sequence: MSTVNVQIGLHELLNGSNAQIQLSVPQLVEKVLMRNEGKLTSTGAVSASTGKYTGRSPKDKFIVKEASVADKIAWGAVNQPISEEHFNKLYTKVLEYLKEKEELFVFKGFAGADRNYRLPIQVINEYAWHNLFVHQLFIRPTEEELTTHESGFTIVSAPNFKADPAVDGTNSEAFIMVSFEKRIVLIGGTEYAGEMKKSIFSIMNFLLPEQDILSMHCSANVGEEGDVALFFGLSGTGKTTLSADPNRKLIGDDEHGWSDNGVFNIEGGCYAKCVNLSHEKEPQIFDAIKFGSVLENVIINNQTRIADYNDTTLTENTRAAYPMHAIDNIVLPSVAGHPNTIIFLTADASGVLPPISKLSKEQAMYHFLSGYTSKLAGTERGVTSPQATFSTCFGSPFLPLDASRYAEMLGEKIEKHDAKVFLVNTGWTGGEYGVGKRMNLGYTRAMIQAALSGELAKTETAKHDIFGLEVPLHVPGVPDEVLMPEQTWADKAAYKAKAIELANEFKENFKKFESVSEDIINLGGPIA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCAM2_BOVIN
Sequence: MGIGKSKMDPCHLSVPWGKSQSVDTSQSHHMSDSKQSEEISLHGDAVCSSTAEMPAEEQEGVEERPEEDTEEEVFLKFVILHAEEDTGEALRVQSLLENDFGIKPGIIFAEMPCGRQHLQNLDDAVNGSAWTILLLTENFLRDTWCKFQFYSSLMNSVNRQHKYNSVIPMRPLNNPLPRERTPFALRTINALEEESRGFPTQVERIFQESVYRIQQAIWKETRNTVQRQSVA
What is the function of this protein?
Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction.  In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4.  In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement.  Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response.  Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria.
What are the official names of this protein?
TIR domain-containing adapter molecule 2, TICAM-2, TRIF-related adapter molecule.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome. Late endosome. Cell projection, phagocytic cup. Note=Localized to the plasma membrane as a result of myristoylation.
Protein: Y1774_OLEA2
Sequence: MKKSESLPVLIVTGLSGAGKSTVLNVFEDLRFFTIDGLPVGVVADLLEHLARDAMGRYRGVVLGMDLRQFDFLDEFEGALMRLEKMGVSPRIIYLEADSDTLVRRFATTRRPHPLEGGDLGLEAAVEHERNLLAPVRERADLILDTSEFSIHDLRRIVQKKWSSLGGSLRSLRVNLITFGFKYGVPSDADMVFDLRFLPNPYFDAKLKALSGKDPEIQQFVLGCEQGKTFFKRFLDFLLFLLPQYEAEGRYRITLAIGCTGGRHRSVSTAEALRDALKKSDYAVSLEHRHIDLG
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Dde_1774.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: ICAC_STAAR
Sequence: MKKIRLELVYLRAIICAIIIVTHLLTQITLKHENMEGGSLVLQFYIRNIVIFGTPCFIILSQLLTTLNYQKVTYRYLTTRVKYILIPYILMGLFYSYSESLLTDTSFQKQFIENVLLGQWYGYFIVVIMQFFILSYIIFKINYNLFNSKILLLLSFILQQSFLYYFTNNTAFHDTVLHYYPLSENTIIFGWIFYFFLGAYMGYNYERVLNFLERYLVIMIVLAVATYFVFIALANGDYWNVTSFSYSLTPYNSIMFIVILGICTHFKTMLFNTIQMISAFSFFIYLLHPIILDSLFAYTNIFEDNTMVFLAISLLFILGLCIGVGMILREFYIFRFIIGKQPYKLNINAY
What is the function of this protein?
Presumably involved in the export of the biofilm adhesin polysaccharide poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA) across the cell membrane.
What are the official names of this protein?
Probable poly-beta-1,6-N-acetyl-D-glucosamine export protein, PGA export protein, Poly-beta-1,6-GlcNAc export protein, Biofilm polysaccharide intercellular adhesin export protein, Biofilm PIA export protein, Intercellular adhesion protein C.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LAC6_ARATH
Sequence: MTSSAVPSLFRLSFLLFTLQVMNIGRIGAATRFYQFKVQTIRLTRLCQTNEIVTVNKKFPGPAISAQEDDRIVIKVINMTPYNTTIHWHGIKQKRSCWYDGPSYITQCPIQSGQSFTYNFKVAQQKGTFLWHAHFSWLRATVYGPLIVYPKASVPYPFKKPFNEHTILLGEYWLKNVVELEQHVLESGGPPPPADAFTINGQPGPNYNCSSKDVYEIQIVPRKIYLLRLINAGINMETFFTIANHRLTIVEVDGEYTKPYTTERVMLVPGQTMNILVTADQTVGRYSMAMGPYESAKNVKFQNTSAIANFQYIGALPNNVTVPAKLPIFNDNIAVKTVMDGLRSLNAVDVPRNIDAHLFITIGLNVNKCNSENPNNKCQGPRKGRLAASMNNISFIEPKVSILEAYYKQLEGYFTLDFPTTPEKAYDFVNGAPNDIANDTQAANGTRAIVFEYGSRIQIIFQNTGTLTTENHPIHLHGHSFYVIGYGTGNYDQQTAKFNLEDPPYLNTIGVPVGGWAAIRFVANNPGLWLLHCHFDIHQTWGMSTMFIVKNGKKVQESLPHPPADLPKC
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products.
What are the official names of this protein?
Laccase-6, Benzenediol:oxygen oxidoreductase 6, Diphenol oxidase 6, Urishiol oxidase 6.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: GATC_BRUSU
Sequence: MSVDISTVKRVAHLARIAVSEDDAERMTGELNAILGFVEQLNEVDVEGIEPMTSVTPMKMRMREDKVTDGGIAAAVVANAPVTEDNFFVVPKVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: PYRE_YERPA
Sequence: MKAYQREFIEFALNKQVLKFGEFTLKSGRISPYFFNAGLFNTGLDLAKLGRFYAAALMDCGVEFDLLFGPAYKGIPIATTTAVALAEHHERDVPYCFNRKEAKTHGEGGNLVGSPLQGRVMLVDDVITAGTAIRESMEIINAQGATLAGVMISLDRQERGRGEISAIQEVERDYHCKVIAIVTLNDVIRYLEDKPEMAEHLVAVRQYREQYGVTL
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: BLAC_MYCTU
Sequence: MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLHQNPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDAEEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPREALLAEAATCVAGVLA
What is the function of this protein?
Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta-lactam ring.  Displays high levels of penicillinase and cephalosporinase activity as well as measurable activity with carbapenems, including imipenem and meropenem.  Plays a primary role in the intrinsic resistance of M. tuberculosis to beta-lactam antibiotics.
What are the official names of this protein?
Beta-lactamase, Ambler class A beta-lactamase.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
What are the subcellular locations of this protein?
Cell inner membrane. Periplasm. Secreted.
Protein: HFD_BPCA1
Sequence: MKRVLNLGNLSRIVEGDPNEITDDEILVIKDKIIEGKIIDIQKRVDGKLVSLITEKYTYTINPTPADAIVVINGSTTKSIRAAKGHTVTWSVSKTGFVTQSGSDVISGDVSKDVTLVANPAS
What is the function of this protein?
Forms short fibers at the surface of the viral capsid.
What are the official names of this protein?
Head fiber dimeric protein, Capsid fiber dimeric protein, Gene product 29, gp29.
Protein: M1_I75A0
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVATTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRAIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: NAPA_ECOL5
Sequence: MKLSRRSFMKANAVAAAAAAAGLSVPGVARAVVGQQEAIKWDKAPCRFCGTGCGVLVGTQQGRVVACQGDPDAPVNRGLNCIKGYFLPKIMYGKDRLTQPLLRMKNGKYDKEGEFTPITWDQAFDVMEEKFKTALKEKGPESIGMFGSGQWTIWEGYAASKLFKAGFRSNNIDPNARHCMASAVVGFMRTFGMDEPMGCYDDIEQADAFVLWGANMAEMHPILWSRITNRRLSNQNVTVAVLSTYQHRSFELADNGIIFTPQSDLVILNYIANYIIQNNAINQDFFSKHVNLRKGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFEDYKAFVAEYTLEKTAEMTGVPKDQLEQLAQLYADPNKKVISYWTMGFNQHTRGVWANNLVYNLHLLTGKISQPGCGPFSLTGQPSACGTAREVGTFAHRLPADMVVTNEKHRDICEKKWNIPSGTIPAKIGLHAVAQDRALKDGKLNVYWTMCTNNMQAGPNINEERMPGWRDPRNFIIVSDPYPTVSALAADLILPTAMWVEKEGAYGNAERRTQFWRQQVQAPGEAKSDLWQLVQFSRRFKTEEVWPEELLAKKPELRGKTLYEVLYATPEVSKFPLSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHDLAPFDDYHKARGLRWPVVNGKETQWRYSEGNDPYVKAGEGYKFYGKPDGKAVIFALPFEPAAEAPDEEYDLWLSTGRVLEHWHTGSMTRRVPELHRAFPEAVLFIHPLDAKARDLRRGDKVKVVSRRGEVISIVETRGRNRPPQGLVYMPFFDAAQLVNKLTLDATDPLSKETDFKKCAVKLEKV
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: BCAT2_ARATH
Sequence: MIKTITSLRKTLVLPLHLHIRTLQTFAKYNAQAASALREERKKPLYQNGDDVYADLDWDNLGFGLNPADYMYVMKCSKDGEFTQGELSPYGNIQLSPSAGVLNYGQAIYEGTKAYRKENGKLLLFRPDHNAIRMKLGAERMLMPSPSVDQFVNAVKQTALANKRWVPPAGKGTLYIRPLLMGSGPILGLGPAPEYTFIVYASPVGNYFKEGMAALNLYVEEEYVRAAPGGAGGVKSITNYAPVLKALSRAKSRGFSDVLYLDSVKKKYLEEASSCNVFVVKGRTISTPATNGTILEGITRKSVMEIASDQGYQVVEKAVHVDEVMDADEVFCTGTAVVVAPVGTITYQEKRVEYKTGDESVCQKLRSVLVGIQTGLIEDNKGWVTDIN
What is the function of this protein?
Converts 2-oxo acids to branched-chain amino acids.  Shows activity with L-Leu, L-Ile and L-Val as amino donors and 2-oxoglutarate as an amino acceptor, but no activity for D-isomers of Leu, Ile, Val, Asp, Glu or Ala.
What are the official names of this protein?
Branched-chain-amino-acid aminotransferase 2, chloroplastic, Atbcat-2.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HELB_HUMAN
Sequence: MARSSPYLRQLQGPLLPPRDLVEEDDDYLNDDVEEDEESVFIDAEELCSGGVKAGSLPGCLRVSICDENTQETCKVFGRFPITGAWWRVKVQVKPVVGSRSYQYQVQGFPSYFLQSDMSPPNQKHICALFLKECEVSSDDVNKFLTWVKEVSNYKNLNFENLRETLRTFHKETGRKDQKQPTQNGQEELFLDNEMSLPLENTIPFRNVMTALQFPKIMEFLPVLLPRHFKWIIGSGSKEMLKEIEEILGTHPWKLGFSKITYREWKLLRCEASWIAFCQCESLLQLMTDLEKNALIMYSRLKQICREDGHTYVEVNDLTLTLSNHMSFHAASESLKFLKDIGVVTYEKSCVFPYDLYHAERAIAFSICDLMKKPPWHLCVDVEKVLASIHTTKPENSSDDALNESKPDEVRLENPVDVVDTQDNGDHIWTNGENEINAEISEVQLDQDQVEVPLDRDQVAALEMICSNPVTVISGKGGCGKTTIVSRLFKHIEQLEEREVKKACEDFEQDQNASEEWITFTEQSQLEADKAIEVLLTAPTGKAAGLLRQKTGLHAYTLCQVNYSFYSWTQTMMTTNKPWKFSSVRVLVVDEGSLVSVGIFKSVLNLLCEHSKLSKLIILGDIRQLPSIEPGNLLKDLFETLKSRNCAIELKTNHRAESQLIVDNATRISRRQFPKFDAELNISDNPTLPISIQDKTFIFVRLPEEDASSQSSKTNHHSCLYSAVKTLLQENNLQNAKTSQFIAFRRQDCDLINDCCCKHYTGHLTKDHQSRLVFGIGDKICCTRNAYLSDLLPENISGSQQNNDLDASSEDFSGTLPDFAKNKRDFESNVRLCNGEIFFITNDVTDVTFGKRRSLTINNMAGLEVTVDFKKLMKYCRIKHAWARTIHTFQGSEEQTVVYVVGKAGRQHWQHVYTAVTRGRCRVYVIAEESQLRNAIMKNSFPRKTRLKHFLQSKLSSSGAPPADFPSPRKSSGDSGGPSTPSASPLPVVTDHAMTNDVTWSEASSPDERTLTFAERWQLSSPDGVDTDDDLPKSRASKRTCGVNDDESPSKIFMVGESPQVSSRLQNLRLNNLIPRQLFKPTDNQET
What is the function of this protein?
5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285).  Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285).  As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285).  Acts independently of TP53BP1 (PubMed:26774285).  Unwinds duplex DNA with 5'-3' polarity.  Has single-strand DNA-dependent ATPase and DNA helicase activities.  Prefers ATP and dATP as substrates (PubMed:12181327).  During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613).
What are the official names of this protein?
DNA helicase B, hDHB.
What is the protein family that this protein belongs to?
Belongs to the RecD family. HELB subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=Predominantly nuclear (PubMed:15146062). Phosphorylation at Ser-967 by CDK2 during the G1/S transition results in its nuclear export into the cytoplasm as cells approach and progress through S phase (PubMed:15146062). Following DNA damage, recruited to sites of double-strand breaks by the RPA complex (PubMed:26774285). Recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment (PubMed:22194613).
Protein: MNTR_BACC2
Sequence: MPTPSMEDYIEQIYLLIDEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTTKGKKIGERLVYRHDLLEQFMRIIGVDEGKIYNDVEGIEHHLSWEAIDRIGDLVEYFEQDAVRVETLRGVQRANEEKSN
What is the function of this protein?
Central regulator of manganese homeostasis.
What are the official names of this protein?
HTH-type transcriptional regulator MntR, Manganese transport regulator.
What is the protein family that this protein belongs to?
Belongs to the DtxR/MntR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHS7_CRYNH
Sequence: MVRHDPFTNSVSEDSSFTPSVNPSTPYPQSGHYRPYYPPQLTYCQGQQGYQYDHTGDVGYGGRSRRHGSWASVNNEDNEELTPLTTGPASSSTFLTTDPYLSGGPDLPLSSSSASISSAGADFLRRQTVPRRGATIKKIKLTNGNFIADYPVPGPVSSSVEAKWLNDKTSNEFWHMRYTAATCDPDDFTPENGWKLKTTSYNRETELLVAITSYNEDKILYARTLHNVMLNIRDICNTKASKFWRRSAEEGRPGWQKIVVALVADGLDPMDKQVLDVLQTIGVFQDGILKKEVDGKKTAAHIFEYTTQLSIDATPQLVQPHPGDPNNLVPVQIIFVLKQENSKKINSHRWLFNALGRQLQPEICVLLDAGTKPGHKAIYHLWEAFYNNQNLGGACGEIHAMIKKGVKLLNPLVAAQNFEYKMSNILDKPLESSFGYVSVLPGAFSAYRYKAIQGRPLTQYFHGDATLAARLGKKGIYGMGIFTKNMFLAEDRILCFELVAKKGEKWVLQYVKPSKAETDVPEQAAELISQRRRWLNGSFAASVYSVFHFFRLYRSGHGPIRMLFLHIQAIYNIFSLIFSWFALANLWLTFSIIIELLPESANINLFGTADITHWINLVFAWVYLAFLMLQLVLALGNRPKAEKGLYILTLWVYAFLSFYLIVCSIILSVVAFKGALRDGGSIGAKLGNLFNSTNGVLVAAIMSTIGIYLIASFLYRDPWHMFSSFPQYMLLAPSFTNVLNIYAFCNLHDVSWGTKGSDRAESLPAISSSKQKDGETAVVEEQQRSQGELDESFKQVVRRAVAPYKPEDADEKPNLDDQNRTFRTRLVVVWLLTNAALAISIQTLNGLDTTKPLVEACLPNSYNPENGTVIVSTNGTCITQALEHDGDKLQDKQQIYFQAILWTTFALSMVRFIGCVFYWAMRQMGRCWRRN
What is the function of this protein?
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
What are the official names of this protein?
Chitin synthase 7.
What is the protein family that this protein belongs to?
Belongs to the chitin synthase family. Class III subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RSXE_SALPK
Sequence: MSEIKDIVVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTVSTLRRWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPWLSALDGFSIGMGATGAMFVLGSLREILGNGTLFDGADSLLGGWAKVLRVEIFHTDSPFLLAMLPPGAFIGLGLMLAVKYLIDEKMKKRRAETAPSAVPAGETGKV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rsx electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UGL_BURCM
Sequence: MKLLRYGPSGQEKPGILDANGRIRDLSAHVPDLAGDALSDAGLTRLRAIDPATLPLVSGEPRIGACVGRVGKFIGIGLNYADHAAEAGMPVPKEPVVFGKWTSSICGPNDGIDIPKGSVKTDWEVELGVVIGTTCKDVDEARALDYVAGYCVVNDVSEREWQIERGGQWDKGKGFDTFGPIGPWLVTRDEVPDPQRLDLWLEVDGHRYQNGNTRTMVFTVAQLVAYLSTCMTLQPGDVITTGTPPGVGMGIKPSPVFLKAGQTVRLGIDGLGEQLQSTRNAR
What are the official names of this protein?
Ureidoglycolate lyase, UGL, Ureidoglycolase, Ureidoglycolatase, Ureidoglycolate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the FAH family.
Protein: SYC_PSYCK
Sequence: MTMTTPLADAMSQLVIYDSLTGRKQAFKPLATGKVGMYVCGMTVYDYCHIGHARVMVGFDMAVRWLAQLGYDVNYVRNITDIDDKIITRAAENGEEIGTLTQRFITAMHEDATALGCLSPDAEPRATDHIDEMQQMIETLVSNDYAYAGDNGDVYYAVDSFADYGKLSKRNLDDMQAGSRVEVENDKRNPFDFVLWKAAKPDEPQWASAWGQGRPGWHIECSAMSTKCLGNTFDIHGGGHDLQFPHHENEIAQSEAATGCEYARNWMHVGFINVDGEKMSKSLGNFFTIRDVMAKYLPETVRFFLLSSHYRSQVNFSDSALDESHNSLSRLYQALKVAEQQKGKVLIIDEALINNAYASAVGQDFIKAMNDDFNSSTAISVLFGLARDINKASKAQDVETAWQLAQHLKALAQTLNILQQPVQQFLQAVIGEVAEDSLTDEAIDGLIIERADAKTNKNFARADEIRVQLKEAGIELEDSRAGTTWRRA
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.