PharMolix/UniProtQA huggingface dataset:
Protein: KCY_VIBVU
Sequence: MSSQTPVVTVDGPSGAGKGTLCMLLSKKLGFQLLDSGAIYRVLALAAIHHGVDTESEDALVPLATHLDVQFVAEGDLVKVILEGEDVSKELRKEETGMAASKVAALPRVREALLRRQRAFEAAPGLVADGRDMGTVVFPNAKAKIFLDASAEERAHRRLKQLQDKGLDVRFDDLLSEIQERDDRDRNRPVAPLRPAEDALVLDSTSMSIDEVVEKALQYIESKLAE
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_ECO55
Sequence: MSEQLVTPENVTTKDGKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEAIDIKAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_HAMD5
Sequence: MKSMLEKINQLRDVLKHHEYLYHVNDAPEITDAEYDALLEKLREWESQYPELMNPDSPTQKVGASPSTAFKPVTHQVPMLSLDNVFDEKGFLAFNKRVSERLEAESSAQKASLNPLVRDSDQKNRSEKNVQEALTFCCELKLDGLAVSLIYEKGELTQAATRGNGFQGENITHNIRTIQSIPLRLKGKALPQRIEIRGEVYMPQAGFEKLNKQARANHEKIFSNPRNAAAGSLRQLDPHITAQRPLNFFCYGVGLLEGGVLPQSHIQRLMQLKAWGLPVHDRITLCTGAEQVMAFYQEIAQARATLGFDIDGIVIKVDDVLLQEKLGFLAKAPRWATAFKFPAQEKTTQVLGVEFQVGRTGALTPVARLEPVELGGALVSNANLHNADEIARLGLRIGDTVVVRRAGDVIPQIVNVIIESRPQNTVEIIFPHHCPICKSVAKRIEGEAVIRCTGGLFCPAQRKEALKHFVARRALDIEGLGDKIIHQLVDKKYVQNPADLFHLTSEKLLSLKRMREKSAQNLLNSLKKSQKTTFARFLYALGIREVGETTAANLALYFGQLDLLRKADIETLKKVPDVGEVVAKNLVDFFGNEHHQQVISALESVLDWPDPEPIEKPNHPFRDKTVVLTGSLNAFTRDDLKAHLISLGAKVSGSVSKKTDFLIAGENPGSKAQKAEKSGIKIMNEPELIEFLKALKPEGTKV
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: ARGC_SYNSC
Sequence: MATVKGGRVAVIGASGYGGLQTIRLLQGHPGLSVSFLGGERSAGQRWSSVCSFLPLPDDPKVESADPDRIAACSDFAVLSLPNGLACQLAPQLLERGVRVVDLSADFRYRSLEQWLQVYAKEAGSLNRQDAELCSSAVYGLPEWNGPAIADAKLVAAPGCFPTASLMPLLPFLKQGLIETSGIIIDAKTGTSGGGRVPKEAMLLAEASESIAPYGVIGHRHTSEIEQMAMEVAGQDIRLQFTPHLVPMVRGLLSTVYARLRDPGLTAEDCTTVLEAIYRHHPCVQVLPVGTYPATKWARHTNRALLSVQVDTRTGQLVLMSAIDNLIKGQAGQGVQCINLMAGLAPETGLPLQSFYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_THEP3
Sequence: MTQLEYALSGIVTKEMKIVAEYEGVDEEFILEGVKKGEIVIPSNINHKNLIPKGIGRGLSTKVNANIGTSDAYPEIEKEIEKLNVAVKAGADAVMDLSTGGDINQSCRKILENSPVPVGTVPMYQAAVESISKYGSIVAMPEEFIFEVIEEQAKDGVDFITVHCGLTFESLKKLKDNGRVMDIVSRGGSFTIAWMLHNNKENPLYKHFDRLLDIAKKYDITLSLGDGLRPGCLEDATDAAQIQELIILGELVKKSREAGVQVMVEGPGHVPIDQIEANVKLQKQLCHNAPFYVLGPIVTDIAPGYDHITSAIGGAIAAASGADFLCYVTPAEHLGLPDKEDVKEGVIAAKIAAHAADIAKGVKGAKEKDLTMARARKALNWDEQIKLSIDPDKAFKYRVNKNISTAKTCSMCGKFCAMKIVSEYLGTSTMTC
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: RL11_GEOKA
Sequence: MAKKVIKVVKLQIPAGKANPAPPVGPALGQAGVNIMAFCKEFNARTADQAGLIIPVEITVFEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATIKRDKVREIAELKMPDLNAASIEAAMRMIEGTARSMGIVIED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PIMT2_MARN8
Sequence: MNKDGQDLSDIRRAMVRCQLVPRGISDGRVLEAMERVPREQFVPEHLRFEAYEDHPVPIGQGQTISQPYIVALMAEALCLKGRERVLDIGTGSGYAAAVLASLALEVFSIERIPELAAQARKNLDRTGFTQVHVKCADGTLGWPEAAPFDGICVAAGAPAVPAALKQQLAVGGRLVIPVGTEGGLQQLLCITRLSDSEYEQASYGDVRFVPLLGEEGWP
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase 2, L-isoaspartyl protein carboxyl methyltransferase 2, Protein L-isoaspartyl methyltransferase 2, Protein-beta-aspartate methyltransferase 2, PIMT 2.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMG_BORBR
Sequence: MFDILVYLFENYYTPQACPAADVLAKRLAAAGFEHEDIDDALGWLYGLAETTERCVELAHAPATGIRIYTDAEYQQLGTESIGFITFLESAGVLPAPLREIVIDRALASPETPISLSKIKIIALMVLWSQEAEIDNLVLEELLDDEGSRRLH
What are the official names of this protein?
Protein Smg homolog.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: SNMP1_MAMBR
Sequence: MLLPKELKYAAIAGGVAVFGLIFGWVLFPVILKGQLKKEMALSKKTDVRKMWEQIPFALEFKVYLFNYTNAEEVQKGAKPILKEIGPYHFDEWKEKVEIEDHEEDDTITYKRRDAFYFNPEMSAPGLTGEEIVVIPHIFMLGMALTVHRDKPAMLNMVGKAMNGIFDSPPDIFMRVKALDILFRGIIINCARTEFAPKATCTALKKEGVSGLVLEPNNQFRFSVFGTRNNTIDPHVITVKRGIKNVMDVGQVVAVDGKTEQTIWRDACNEYQGTDGTVFPPFLTENDRIQSFSTDLCRSFKPWYQKKTSYRGIKTNRYIANIGNFSEDPELHCFCPDPDKCPPKGLMDLAPCIKAPMYASMPHFLDSDPALLNNVKGLNPDINQHGIEIDFEPISGTPMVAKQRIQFNLQLLKTEKIDLFKDLSGDIVPLFWIDEGLALNKTFVNMLKHQLFIPKRVVGVLRWWMVSFGSLGADIGIVYHFRDHIMRLAVSGDTKVSKVTPEEDPEQKDISVIGPPAQEPAKINI
What is the function of this protein?
Plays an olfactory role that is not restricted to pheromone sensitivity.
What are the official names of this protein?
Sensory neuron membrane protein 1.
What is the protein family that this protein belongs to?
Belongs to the CD36 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CH10_PARDE
Sequence: MAFKPLHDRVLVRRVQSDEKTKGGLIIPDSAKEKPAEGEITSVGEGARKDSGELIAPAVKAGDRVLFGKWSGTEVTVDGEELLIMKESDILGIIA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_BRUO2
Sequence: MNTDDVLAVFREAGAILEGHFILTSGLRSPVFLQKARVFMHADKTEKLCKALAEKIRAADLGPIDYVVGPAIGGLIPSYETSRHLGVPSVWVERENGVFRLRRFDVPKGARVVIVEDIVTTGLSIRETIDCMKDLGIEVVAAACIVDRSAGKADVGTRLISLAEYEVPAYPADKLPPELAAIPAVKPGSRNI
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: MLTF_MARMM
Sequence: MKTWPSRAVSLLLLALALPVGCSEPPPPVRDPDTLATIRERGELVVLTLAGPTSLIENEDGPPSGYEVDLANAFAASLGVTARFEVAASLPDLFDALAAGDGHVAAAGLTLTPERSERLAFSPVYKSVTEQLVCRRGGVNPTRLERLPDADIVVLEGSSYEETLRAIGVTHTALRWRTRPGGSAMPLLEAVDDGQADCTIADSHLADFARRRHPELIVARNLTGEQPLAWAYDARIDGLGEALSAWFATAHADGLLEALDETWFGRFGDYDYVDVARFVRRVENRLPRYRRLFEAAADELPFEWELLAAQAYQESHWDPDAVSATGVRGLMMLTLSTAERVGIDDRTDPEQSIVGGAAYLDDLYERVPDSVTGPDRLWFALAAYNVGMGHMYDARRLAERLGRDKDSWDDLAEILPLLSDPAHYSTLRYGYARGHEPVRYVAKIREYRALLAAQDL
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: SWET1_DICDI
Sequence: MEDEKNENLMTFIQFCATFITITLFIMPLKTIRLIIEKKNVGTVAGLQFISSVLNCFLWISYALLTSNTTMLFVNSIGMMFSIYYVFNYWKNINQVRASRDYLKKVMIACVLAITIISISYYNTVDDLDTRISRLGFLSSVVCVLMFASPLEKMAIVIQSKNSEGMIINVAILSLLCGLSWTIFGLLLNDIYIYLPNILASILSFVQLTLIKLYPPQILL
What is the function of this protein?
Mediates both low-affinity uptake and efflux of sugar across the membrane.
What are the official names of this protein?
Sugar transporter SWEET1.
What is the protein family that this protein belongs to?
Belongs to the SWEET sugar transporter family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RAPA_CROS8
Sequence: MPFTLGQRWISDTESELGLGTVVAIDARMVTLLFPATGENRLYARNDSPVTRVMFNPGDTVTSHEGWQLKVDEVKEENGLLIYIGTRLDTLEENVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYQSEQYRMPWSGLRGQRTNLIPHQLNIANDVGRRHAPRVLLADEVGLGKTIEAGMIIHQQLLAGAAERVLIVVPETLQHQWLVEMLRRFNLRFSLFDDERYAEAQHESDNPFDTEQLVICSLDFVRRNKQRLEHLCDAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAERVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQQNYRPVADAVALLLAGTHLSDEQLNTLSELIGEQDIEPLLQTANSDRDGAESARQELVSMLMDRHGTSRVLFRNTRNGVKGFPQRELHTIKLPLPTQYQTAIKVSGIMGARKSAEERARDMLYPEQIYQEFEGDSGTWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASQLVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRAIYDSVYEQLIGYLAAPENTEGFDALIQACRKQHDELKAQLEQGRDRLLEIHSNGGEKAQQLADAIAEQDDDTGLVNFAMNLFDIVGINQDDRGEHMIVLTPSDHMLVPDFPGLPEDGCTITFNRDVALSREDAQFITWEHPLIRNGLDLILSGDTGSCTISLLKNKALPVGTLLLELIYVVEAKAPKQLQLNRFLPPTPVRMLLDKNGNNLAGQVEFESFNRQLSAVNRHTGSKLVNAVQQEVHAILQGGEAQVEKAARELIDAARQEADDKLSAELSRLEALRAVNPNIRDDELAAIEHNRQQVLENLNQASWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: FYV1_DROME
Sequence: MTSNNQNNSSSHQHLHSPSKLTEFARNFEDKPESLFGRVVNKIQNVYNQSYNTVNDISSGSSSSSSTQPVQVVGKSQFFSDSQTSTAEIADVETSSQSSVRPQPPTTLSIRTNSETRGTSTSSNTAAEDSETSDRVETLPLPTSEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSSSSEMGQDMQELQQHLSNKLEVQDSGSSLAKHPQMQRAPLPRKTSVGYQEERFSSHPTYTTLSIDDRKNILQQSNSLITLHEEMQRDLPAQNCGQRLIEFLNSNNKSANEVQAVAILNAMLAAGFLEPIVPDPEQMDFDSSLHYKFSKSSSSDTSRTMSPQFEANPHAEPQPPKSMDQSAEEKEKELENELENDRCYTTATSKLLASYCEHEEQLLAQMLRAHNLDQEWDKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQCPIVYERIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVVLVHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIRNYNGKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLEMSFLLNEFAQPLSPKPSIFDSKETSPKTETEAELRSKRPIILERKSEDKITTIVSENVSDFTDPLRASQAEALSTSPCAPPVVEALAVEPRYDNRFRTALSSTLLSVSPFLTFPLPYLETEQGRKCKLRKLFPAELYFSKQWSRTGLERPDSMGDGEAGKSEPGNKENQMQLLPAHDFVLMKITAPASSRDIQSKLAEFRSFGGRLPKGKAPMLRPKKKNAEVIQRPQKVSEEQLYKDALDPQNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLEQFLQRYCCLFNSMCPSCNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDPTRIYFTSWCSICNATTPTIPLSDAAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGAKFQYTPVEVWETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADLATEEENSPLVQHLKTMLTHDQFIFKQKIEIVHTLLTDNRATAYDTSDALAMARRALAESIELWGPRLQEIEKLTAKQAHHIDSGTICTEELRPEQVQTADSSKVTTSSLPKENDPLECPSEDTETGASNSQTVLDKNFSIDQMLASTVNVYSDKKSIRKILTQLLPSGNQVNPLQSPFPAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEANSNAAHSSPQLKRKIPLAESVSDAEDSPSLSRTSSNTSAAPNASVPSPATAASESEEKSKERIKQPPSPHITLAFQDHSCQFQCKIYFAREFDAMRSKSLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQEEDARIALARSLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVSVKKKDSFVERSVMVMENLFYGCNIENKFDLKGSERNRLVDPSNQQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAMDRYFLTVPDRWEGLSKV
What is the function of this protein?
Regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) or PtdIns(3,5)P2) (PubMed:16837550).  Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)) on the fifth hydroxyl of the myo-inositol ring, to form PtdIns(3,5)P2 (PubMed:16837550).  Required for endocytic-vacuolar pathway and nuclear migration.  Has a role at a late stage in endosome-related membrane trafficking, at a point when signal termination has occurred.  Is not required for receptor silencing.
What are the official names of this protein?
Putative 1-phosphatidylinositol 3-phosphate 5-kinase, Phosphatidylinositol 3-phosphate 5-kinase, Type III PIP kinase, PIPkin-III.
What are the subcellular locations of this protein?
Endosome membrane. Note=Mainly associated with membranes of the late endocytic pathway.
Protein: PYRD_CORDI
Sequence: MRTKAYALALKGMFTMSPERIHHIITRGMQLVQAISPLRRAVGSILPVNDPILRQEVFGVTFPQPLGLAAGFDKNGEAPDVWAAFGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNRMGFNNLGAAEVAKNLKRRKSDAVIGINIGKTKVVASKDAVNDYRRSALLLGNLADYLVINVSSPNTPGLRDLQAVESLRPIIAAVQESTSVPVLVKIAPDLSDDDIDAVADLAVEMGIAGIVATNTTISRNGLRTPHQDVADMGAGGISGAPVAQRSLEVLERLYAHVGTEMVLIGVGGISTPQQAWERIAAGATLLQGYTGMIYGGPDWIRDIHLGIAAQLRAHDLSSIDQAVGSKLPWTLQ
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CFXQ_XANFL
Sequence: MLDVATSAPSAALPAEAAEGRLDLGALFTESEVPEFLAELDEGLIGLKPVKRRIREIAAHLVIGRAREKLGLTSGAPTLHMAFTGNPGTGKTTVALKMAQILHRLGYVRRGHLVSVTRDDLVGQYIGHTAPKTKEILKKAMGGVLFIDEAYYLYRPENERDYGQEAIEILLQVMENQRDDLVVILAGYKDRMDRFFESNPGFRSRIAHHIDFPDYEDAELVEIAKTMAADADYTFSPEAEVAIEEYVAKRRLQPNFANARSIRNALDRMRLRQSLRLFESGGLADRAALSTISEGDVRASRVFAGGIDAPDYKPQTE
What is the function of this protein?
Necessary for the expression of RuBisCO.
What are the official names of this protein?
Protein CfxQ.
What is the protein family that this protein belongs to?
Belongs to the CbxX/CfxQ family.
Protein: MOTA_TREPA
Sequence: MDIASFIGLFGGFAIIIFGAVLGGSARGLFHVPSLLITVGGSYLTLFLTYPLSYAVGVFRVIARVFHAADFHEREIVQRLYALAEKSRRTGLLALEEEIQDFDDDFVRTGLRNVVDGVDGDAIKALMESELTHMEDRHNTWISLLNSWAALAPGYGMLGTVMGLIGMLATLEDKSSLGSNMATALITTFYGSLVQNWFITPVATKLQYQHDLEVKSKEMVIEGVLSIQAGDHPRVLAQRLLTYLSPKMRKELEMELIKD
What is the function of this protein?
MotA and MotB comprise the stator element of the flagellar motor complex.  Required for rotation of the flagellar motor.  Probable transmembrane proton channel (By similarity).
What are the official names of this protein?
Motility protein A, Chemotaxis protein MotA.
What is the protein family that this protein belongs to?
Belongs to the MotA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HUTI_NOCSJ
Sequence: MASTLITNIGELVTNDPEAADDGRGLLGIVEQAALVIDGSTVAWVGRAADAPDADQLVDAGGRAVLPGFVDSHSHLVFAGDRAAEFAARMAGTPYAAGGIRTTVAATRAATDEQLTSHVARLVEEMRRQGTTTVEIKSGYGLTVHDEARSLAVARQFTEETTFLGAHVVPDGDPGEYVDLVTGPMLDAAREHARWIDVFCERGAFDADQARAILDAGAAAGLRGRLHANQLTYGEGVRLAAELGLVAVDHCTYLADEDVAALRDSGTIATLLPGVEFSTRQPYPDARRLLDAGVRVALASDCNPGSCFTSSIPLCIALAVREMGMTPAEAVHAATYRGAQALDRDGQHGIGALVPGRRADLAVLDAPSHVHLAYRPGVPLVRQTWVAGRPL
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGC_ECO57
Sequence: MVSLEKNDHLMLARQLPLKSVALILAGGRGTRLKDLTNKRAKPAVHFGGKFRIIDFALSNCINSGIRRMGVITQYQSHTLVQHIQRGWSFFNEEMNEFVDLLPAQQRMKGENWYRGTADAVTQNLDIIRRYKAEYVVILAGDHIYKQDYSRMLIDHVEKGARCTVACMPVPIEEASAFGVMAVDENDKIIEFVEKPANPPSMPNDPSKSLASMGIYVFDADYLYELLEEDDRDENSSHDFGKDLIPKITEAGLAYAHPFPLSCVQSDPDAEPYWRDVGTLEAYWKANLDLASVVPELDMYDRNWPIRTYNESLPPAKFVQDRSGSHGMTLNSLVSGGCVISGSVVVQSVLFSRVRVNSFCNIDSAVLLPEVWVGRSCRLRRCVIDRACVIPEGMVIGENAEEDARRFYRSEEGIVLVTREMLRKLGHKQER
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: VE6_HPV10
Sequence: MSMGAQEPRNILLLCRNCGIPLEDLRLCCIFCTKQLTAAELAAFALRELYLVWRAGVPYGACARCLLLQGIVRRLKYWDYSYYVEGVEEETKQSIYTQLIRCYMCHKPLVREEKDRHRNERRRLHKISGYWRGSCEYCWSRCTVRIPQ
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation.  In turn, apoptosis induced by DNA damage is inhibited.  E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: SYGA_XYLFM
Sequence: MSDSRGVLSISTSTTFQGLIQTLNRYWAEQGCVLVQPLDLEVGAGTFHPATFLRALGPEPWNAAYVQPSRRPTDGRYGENPNRLQRYYQYQVAMKPNPDNLQELYLASLQALGIDPLVHDVRFVEDNWESPTLGAWGLGWEVWLNGMEVTQFTYFQQAGGLECKPVLGEVTYGLERLCMYLQSCDNVYDLVWTYGPDGTPVTYGDVYHQNEVEQSAYNFEHANVTELLHTFDACEREAKSLVEAVLPLPAYEKVIKASHCFNLLDARRTISVTERQRYILRIRTLSQEVAKAYYAQREKLGFPNLRR
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAE10_ARATH
Sequence: MRKLFLLGFIVAGLVLGNEANGYLEFNVTELDRIEDLEFGFSKFSSNFNPLMVGLTLIRGAGSKGAVCLDGTLPGYHLHRGHGSGANSWLIQLEGGGWCDNIRNCVYRKKSRRGSSNYMEKQIQFTGILSNKAQENPDFFNWNRVKLRYCDGGSFSGDSQNKAARLQFRGEKIWRAAMDDLKAKGMRNAKQALLSGCSAGGLAVILRCDEFRNLFSGWTRVKCLSDAGLFLDTPDVSGGHTIRNLYNGVVQLQGVKNNLPHLCTNHLNPTSCFFPQNLISQMKTPLFIVNAAYDIWQIQSSIAPPSADPSGYWHECRLNHGRCTPAQIRFLQGFRNQMLRAVSGFSNSKKNGLFINSCFAHCQTERQDTWFADDSPVIHKKAVAIAVGDWYFDRAEVKLIDCPYPCDRSCHNLVFR
What is the function of this protein?
Hydrolyzes acetyl esters in homogalacturonan regions of pectin.  In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions.  Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
What are the official names of this protein?
Pectin acetylesterase 10.
What is the protein family that this protein belongs to?
Belongs to the pectinacetylesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: CP17A_PAPHU
Sequence: MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTLDILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFRSDSITNMLDVLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEGIDQNVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST
What is the function of this protein?
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis.  Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways (PubMed:12423360).  A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage.  Hydroxylates pregnenolone to form 17-alpha pregnenolone, followed by the cleavage of the C17-C20 bond to form dehydroepiandrosterone (DHEA) (PubMed:12423360).  Has 17-alpha hydroxylase activity toward progesterone (PubMed:12423360).  The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity).
What are the official names of this protein?
Steroid 17-alpha-hydroxylase/17,20 lyase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Microsome membrane.