PharMolix/UniProtQA huggingface dataset:
Protein: PAOX_HUMAN
Sequence: MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVLEATARAGGRIRSERCFGGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASSGASVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVAGWTEDEETRKLKLAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVLPGLDCTFSKGYQGLTNCMMAALPEDTVVFEKPVKTIHWNGSFQEAAFPGETFPVSVECEDGDRFPAHHVIVTVPLGFLREHLDTFFDPPLPAEKAEAIRKIGFGTNNKIFLEFEEPFWEPDCQLIQLVWEDTSPLEDAAPELQDAWFRKLIGFVVLPAFASVHVLCGFIAGLESEFMETLSDEEVLLCLTQVLRRVTGNPRLPAPKSVLRSRWHSAPYTRGSYSYVAVGSTGGDLDLLAQPLPADGAGAQLQILFAGEATHRTFYSTTHGALLSGWREADRLLSLWAPQVQQPRPRL
What is the function of this protein?
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380).  Can also oxidize N(1)-acetylspermidine to putrescine.  Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine.  Does not oxidize spermidine.  Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380).
What are the official names of this protein?
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, Polyamine oxidase.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
What are the subcellular locations of this protein?
Peroxisome. Cytoplasm.
Protein: PKZ1_PHYIT
Sequence: MLRLGRSAASEVSSIRNSLQLQLEQRGARPMQCAYQTQSHSNPEGAKRGRSPMSLAVMGAAALSVGLELQTDGIAQARAAMEPGTQLQRHKWQLFDQIGAGAFGVVRLGMHEESGEVAAVKIVPLENPNDQRSYPALEREIAALKLVKALGGHNSIVDLRDVYVEGRKLFLVTELARGGELFEQIVAYGSFPELKARDVAREMASALSFMHRHGLVHKDVKPENILMSARVVDHNSGVYRKSNRHESSSLVKLADFGSAGPASVNTNLEDIGTAAYLPPEVLNSGLCTSACDMWALGCVLYIMLSGSHPYDLDGMSADSVVEHRVKSEPVTFDFSAWDNVSPHAKDLISKLLVKDPTLRLTADQMLQHPWMNASAEAAAAGLRRPSPLLAGQPIPISPA
What is the function of this protein?
May regulate an early stage of the zoospore pathway.
What are the official names of this protein?
Serine/threonine-protein kinase PKZ1, Cleavage-induced protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Protein: NDK_MYCSS
Sequence: MTERTLVLIKPDGVQRRLVGEILGRIERKGLTLAALELKTVDDELARRHYAEHEGKPFFGSLLEFITSGPVVAAIVEGPRAIAAFRQIAGGTDPVEKATPGTIRADLALVTQDNLVHGSDSPESAAREIDLWFPGR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_PYRNV
Sequence: MRIYNTATRQVEEFTTYVPRLARGYVCGITPYDHMHVGHGRVYVFFDIFRRYLERLGYEVRLVINFTDIDDKIVNKAREEFGHEAYKRWREVPERYIAEYFEMTRRLYIKPAYAYPKVTENVEDMVKWISTLVEKGYAYVAPDGSVYFEVAKVPNYGVLSRQKIEELIAGARVEPEPGKRNPLDFALWKSWTPGEPWWNSPWCPGRPGWHLECVVMSTKHLGAPFDFHGGGADLIFPHHENEIAIARAYFGVDNFARYWIHVGYLTVRGEKMSKSLGNIITLREVLSKHSGEALRLAYAMSHYRKPMEFTYELLQQAEDMAKTLYTAYDELSQALRDAGEKDQEPIAQEALKYAGAFYGALDDDMSTPEAVQQLYGMARYIISTVLHRVEKISRETALAVLNKYVEMADVLGVLERRQIPKELEEAVKALVETRARLRQERQYQLADYIRQRLAELGVELHDFGPRTYYTYRRA
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTQA_BACSU
Sequence: MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPNRDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTNTHAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQTVHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADLDVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGDGPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL
What are the official names of this protein?
Uncharacterized protein YtqA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily.
Protein: SERC_FLAJ1
Sequence: MKKHNYSAGPSILPQEVFEKASKAVLNFNDSGLSILEISHRSKDFVAVMDEARSLALELLGLQGKGYQALFLQGGASTAFLMAPYNLMKENGKAAYLDSGTWATAAIKEAKLFGETVIVGSSKDDNYTYIPKGYEIPADADYFHCTSNNTIFGTQIQEFPSTNIPVVCDMSSDIFSRELDFSKFDLIYAGAQKNMGPAGTTLVVVKEEILGKNGRTIPSMLDYAKHIKAESMYNTPSVFAVYVSLLTLQWIKAKGGIAAVEKLNNAKADLLYAEIDRNPLFKGAANVEDRSKMNVTFLLNNPEHTETFDALWKAAGISGLPGHRSVGGYRASIYNAMPIESVQVLVDVMKALESKV
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPD_COREF
Sequence: MSRLPVVALLAAAGRGTRLGGPIPKAFVTLRGRSLVERSLRAMLTSEVVDEVIILVSPDMEDYARELLTRRGLLNDPEGVRVRLVHGGGERADSVWAGLQAIDHDDAIVLIHDSARALTPPGMIARVARMVADGAPAVIPVVPVADTIKRVDGSTVVDTPNRADLRAVQTPQGFLLSRLRAANEKFFATPDPGFIPTDDASLMEWYGVEVTCVQGDPMAFKVTTPIDMMLAQRITDEAEPTIFEVPGD
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: VIRF_SHIFL
Sequence: MMDMGHKNKIDIKVRLHNYIILYAKRCSMTVSSGNETLTIDEGQIAFIERNIQINVSIKKSDSINPFEIISLDRNLLLSIIRIMEPIYSFQHSYSEEKRGLNKKIFLLSEEEVSIDLFKSIKEMPFGKRKIYSLACLLSAVSDEEALYTSISIASSLSFSDQIRKIVEKNIEKRWRLSDISNNLNLSEIAVRKRLESEKLTFQQILLDIRMHHAAKLLLNSQSYINDVSRLIGISSPSYFIRKFNEYYGITPKKFYLYHKKF
What is the function of this protein?
Primary regulator of plasmid-encoded virulence genes.  Activates the transcription of icsA (virG) and of virB, which is an activator of the ipaABCD virulence regulon.
What are the official names of this protein?
Virulence regulon transcriptional activator VirF.
Protein: RF1_STRP1
Sequence: MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTRETVTAYREYKQVIQTISDAEEMIKDASGDPELEEMAKEELKESKAAKEEYEEKLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGGIKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDPKDLRVDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTILSGKMDEVIDALVMYDQTKKLESLNN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_BREBN
Sequence: MYAIIETGGKQYKVEEGAVLFIEKLADVEGEVVTFDKVLLVSKDGKVTAGAPTVAGATVTGKVEKHGKAKKIIVYKYKAKKNYRRKQGHRQPFTKVVIEKINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: TAF9_ARATH
Sequence: MAGEGEEDVPRDAKIVKSLLKSMGVEDYEPRVIHQFLELWYRYVVEVLTDAQVYSEHASKPNIDCDDVKLAIQSKVNFSFSQPPPREVLLELAASRNKIPLPKSIAGPGVPLPPEQDTLLSPNYQLVIPKKSVSTEPEETEDDEEMTDPGQSSQEQQQQQQQTSDLPSQTPQRVSFPLSRRPK
What is the function of this protein?
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 9, TATA binding protein associated factor 21kDa subunit, TBP-associated factor 9, AtTAF9.
What is the protein family that this protein belongs to?
Belongs to the TAF9 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: B2KB6_SICCD
Sequence: WIMGHMVNAIEQVDEFLNLGANAIEFDIDFGKDGIAQITHHGIPCDCGRKCTKKAIFTEYLDNIRQVTTPDDPKFREQLVLLALDLKPQRISSAKAYRAGEDVAKKLLDHYWQRGNSRARAYILLNIPLVEDYEFIRAFKDTLRNEGYESYNDKVGINFTGNEDLDKIRDVLEILGILKQVWQADGITSCFARGTERLKEALEKRDTPGYNYINKVYAWTLVRKSIMRRSLRLGVDGVMSNNPDRVIKVLKEKEFADKFRLATYNDNPWERFRG
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SdSicTox-betaIIB1bvi, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DPO4_SALAR
Sequence: MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRECRGVISTANYPARQFGVRSAMPTAMALKLCPHLTLLPGRFDAYKEASRHVRDIFSRYTSLIEPLSLDEAWLDVTDTPHCYGSATLIAREIRQTIFNELQLTASAGVAPVKFLAKIASDLNKPNGQYVITPADVPDFLKTLPLAKIPGVGKVSAAKLESMGLITCGDIQQCDLAMLLKRFGKFGRVLWERSQGIDERDVNSERLRKSVGVERTLAEDIHEWSDCEAIIERLYPELERRLATVKPDLLIARQGVKLKFNDFQQTTQEHVWPQLNKEDLISTARKTWNERRGDRGVRLVGLHVTLLHPQLERQLVLGL
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFCP2_HUMAN
Sequence: MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDNENKILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPEINGKLVKSIFRVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPAKRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKENENGEYTEHLHSASCQIKVFKPKGADRKQKTDREKMEKRTPHEKEKYQPSYETTILTECSPWPEITYVNNSPSPGFNSSHSSFSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFSGADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQESLQLREQQQQQQQQQQKHEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSISPCQISQIYKQGPTGIHVLISDEMIQNFQEEACFILDTMKAETNDSYHIILK
What is the function of this protein?
Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters.  Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity).  Functions as part of the SSP (stage selector protein) complex.  Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells.  Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.
What are the official names of this protein?
Alpha-globin transcription factor CP2, SAA3 enhancer factor, Transcription factor LSF.
What is the protein family that this protein belongs to?
Belongs to the grh/CP2 family. CP2 subfamily.
Protein: RECO_COXBU
Sequence: MTKRVALEPAFILHRRPYSNTSLILELLTPNHGRVCALARSARGLKSRYKGKLELFSPLLISWSGRSDLKFLGDVEANGMPYLLEGEALLCGFYLNELLIRLLHHDDPYLRLFHHYQNTLEKLVNGRLEATLRCFEKQLLDELGYGLPLSCDVEMKLPFKPDQFYQYLPDRGFLLCEKSEERDVFSGKSLLALQEESFSDESSLKEIKYLMRLTLNRLLGKKPLKTRELLF
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RL1_STRE4
Sequence: MAKKSKQMRAALEKVDSTKAYSVEEAVALAKETNFAKFDASVEVAYNLNIDVRKADQQIRGAMVLPNGTGKTQRVLVFARGAKAEEAKAAGADFVGEDDLVAKINGGWLDFDVVIATPDMMAIVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGKITYRADKAGNVQAIIGKVSFDADKLVENFKAFHEVMVKAKPATAKGTYMTNVSITTTQGVGIKVDPSSF
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: ANEA_ASPA1
Sequence: MTRSSPKSILRRVAAHEGAPKILQVLKEDGAVIIRGFLNQNLFQKLNKEMEDELAKRPLICEHNGEWVSGLAGSQTRRLNQLPAFSPTFRQEILNHPLFHEICEPLFGTHGCDYWMNTATVVQIGPGNAAQSLHRDQELYPVFNPIGKDAPEALVNFFCALSTFTDENGATRVIPGSHQWDDFTTDVTRCVPQTIPAEMEAGDCLLFSGKTVHGGGANRSKDNVRRGMALGVQATYLTAEENYQHIPREIVESMTPLAQKMIHWRSSYCPGGAGLWQINGTELANEIGLKANQPKKTI
What is the function of this protein?
Dioxygenase; part of the gene cluster that mediates the biosynthesis of aculenes, a unique type of norsesquiterpenes that contain a nordaucane skeleton linked to an L-proline moiety and are of mixed biosynthetic origin (PubMed:31618514).  The pathway begins with the synthesis of dauca-4,7-diene by the terpene cyclase aneC using farnesyl pyrophosphate (FPP) as substrate (PubMed:31618514).  The cytochrome P450 monooxygenase aneF then performs the initial oxidation at C-12 of dauca-4,7-diene to yield asperaculane D (PubMed:31618514).  Asperaculane D is substrate of the cytochrome P450 monooxygenase aneD for C-10 hydroxylation to yield asperaculane E (PubMed:31618514).  The cytochrome P450 monooxygenase aneG then converts asperaculane E into aculene D via C-2 oxidation (PubMed:31618514).  The monomodular nonribosomal peptide synthase aneB adenylates L-proline and the thiohydrolase aneE transfers this activated L-proline derivative to aculenes D and C to produce respectively aculenes B and A (PubMed:31618514).  The dioxygenase aneA converts aculene D into aculene C, and aculene B into aculene A by introducing the 5,6-alkene moiety (PubMed:31618514).  Asperculanes A, B, C and F, as well as 14-prolyl asperculane C, might be shunt products of the pathway (PubMed:31618514).
What are the official names of this protein?
Dioxygenase aneA, Aculenes biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: MUTL_SALNS
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIALARFDVTFNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWVADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETTLPLEEIAPAPRHVPENRIAAGRNHFAVPAEPTAAREPATPRYSGGASGGNGGRQSAGGWPHAQPGYQKQQGEVYRALLQTPTTSPAPEPVAPALDGHSQSFGRVLTIVGGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQSPVCAQPLLIPLRLKVSADEKDALQQAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNIAQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: STAT2_MOUSE
Sequence: MAQWEMLQNLDSPFLDQLHQVYSQSFLPMDFRQHLASWIEDQNWREAALESDDAKANMLYFSILDQLNQWDHYSSDPKSLLLQHNLRKFSRDIQPFPNGPSQLAEMIFNLLLEEQRILIQAQRAQEVQPPPAPEAVVESQQLEIENRIQGLHVDIEFLVRSIRQLKDEQDVFSFRYTVFSLKKTSSSDPHQSQQAHVVQATANKVDRMRKEVLDISKGLVGRLTTLVDLLLPKLDEWKVQQQKSCIGAPPPVKSAAEQLEQWLTAGAKFLFHLRQLLKQLKEMSCLRYQGDMFAKGVDLRNAQVMELLQRLLQRSFVVETQPCMPQTLHRPLILKTGNKFTVRTRLLVRLQEGSESLKAEVSVDRNSDLPGFRKFNILTSNQKTLTPEKGQRQGLIWDFGFLTLVEQRAVGAGKGNNKGPLAVTEELHVISFVVEYTYQGLKMKLQTDTLPVVIISNMNQLSFAWASILWFNMLSPNPKNQQFFCQAPKAPWSLLGPVLSWQFSSYVARGLDSEQLGMLRTKLFGKSCKMEDALLSWVDFCKRESPPGKIPFWTWLDKILELVHDHLKDLWKDGRIMGFVSRNQERRLLKKMLSGTFLLRFSETSEGGITCSWVEHQDDHKVEIYSVQPYTKEVLQSLPLTEIIRHYQVLAEENIPENPLRFLYPRIPRDEAFGCYYQEKVNLEEQEEYLKHKLIVISNRQVDELQQPLELKQDSESLEVNAELLLAHDQELPLMMQTGLVLGTELKVDPILSTAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVQLEPAPQVLLELAPQVLLEPAPQVLLELAPQVQLEPAHLLQQPSESDLPEDLQQISVEDLKKLSNPSTEYITTNENPMLAGESSGDETSIPYHSHFDADGLLGWTLDTF
What is the function of this protein?
Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta).  Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2.  The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus.  ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.  In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs.  Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.
What are the official names of this protein?
Signal transducer and activator of transcription 2.
What is the protein family that this protein belongs to?
Belongs to the transcription factor STAT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Protein: RK2_PROWI
Sequence: MAIRFFKPTTPGRRHGSVLNFDDLSSKKPEKKLTRGWSRAQGRNNKGRITTRHRGGGHKRLYREIDFIRNKIGTSAIVKSIEYDPNRTARIALVCYKDGEKRYILSPTGLKVGEMVIASPNAPITVGNTLPLYNIPLGTSVHNVELQPGAGGQLVRSAGSVAQIVAKEGQWATLHLPSGEYRLIPQKCWATVGRVGNLDNSNITLGKAGRSRWLSQRPHVRGSAMNPVDHPHGGGEGKAPIGRARPVSLWGKPALGVKTRKRKKFSNNLIINL
What are the official names of this protein?
50S ribosomal protein L2, plastid.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid.
Protein: TR09_CURCL
Sequence: MESEDNPLRIQTGSLCSFQRPTPLVLIHDSSGTTFSYFRLGSLNRDVWAIHDPHFDKSTPWKGGFGEIAEHYIKLIETAGIRGSILLGGWSLGGYLALTIAHKLTAITNPTFSVTGILLVDSPYHTPMSKLPPHAPDPNFQHLPELVRKSFENYDVLLDRWELPPWTAPALEGKTIRCSAGGKTFTVANGRILYKPLGKGWEDVKMQSFEHGTSTLERYIELPPAALIRCAQAIPTDTDSKMPCFVDRFRHETLLGWDSNFPSFIKAAVDTNTHHFNIFESQNLKRLTIQLNECLEVLDSCCPMGYC
What is the function of this protein?
Probable thioesterase; part of the gene cluster that mediates the biosynthesis of KK-1, a novel cyclic decapeptide compound with potent antifungal activity (PubMed:29686660).  The nonribosomal peptide synthetase (NRPS) catalyzes the elongation and cyclization of the decapeptide chain composed of 1 pipecolic acid residue (Pip), 1 alanine residue (Ala), 1 aspartic acid residue (Asp), 1 isoleucine residue (Ile), 1 glycine residue (Gly), 1 tyrosine residue (Tyr) and 4 valine residues (Val) (PubMed:29686660).  The Asp, Ile and 3 Val residues are N-methylated by the 5 methyltransferase domains from the NRPS (found in modules 3, 5, 6, 7 and 9), whereas the Tyr residue is O-methylated, probably by the cluster encoded O-methyltransferase OMT (PubMed:29686660).  The other tailoring enzymes from the cluster may be involved in further modifications leading to the synthesis of KK-1 (Probable).
What are the official names of this protein?
Probable thioesterase TR09, KK-1 biosynthesis cluster protein TR09.
What is the protein family that this protein belongs to?
Belongs to the AMT4 thioesterase family.
Protein: DHQS_HALS3
Sequence: MTRSVWLKADDEVGDWETRKRRITAGLEAGVDWVLVDRADVARVRELGSVNVAAFSTDDANVIEDAEGTDADPDAYVAGKDGEGDGTVDLPADFSGSADLSALRRGHADTAYVRIRDEEYEPFAQAAAEVADHTIVVGDDWTIIPLENLIARIGEETTLVAGVESAAEAETAFETLDIGADAVLLDSDDPDEIRRTVSVRDAADREHLALSTATITTIEEAGSADRVCVDTGSLLADDEGMLVGSMSRGLFFVHAETAQSPYVAARPFRVNAGAVHAYVRTPDGGTKYLAELGSGDEVQVVDGDGRTRSAVVGRAKIEKRPMFRVEAETDDGDRIETLLQNAETIKVATPNGRTAVTDLSVGDDLHVFLQDGGRHFGEAIDERIIEQ
What is the function of this protein?
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
What are the official names of this protein?
3-dehydroquinate synthase, DHQ synthase, 3-dehydroquinate synthase II.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type DHQ synthase family.
Protein: ANMK_BRUAB
Sequence: MPDLKRAIGLMSGTSMDGIDIALLATDGENWIERRASASMDYSDGFRARLKAGLVDARAIKDRAERPGLLRQLEHDLTLLHAVAVHDFLHEQGLQPHEIDVIGFHGQTVLHRPNESLTVQIGDGALLARETGIPVVYDMRAEDMRHGGQGAPLIPAYHAALAANLPLGLKGPVVFVNIGGISNLTYVGEDGALIAYDSGPGNMLIDQWMELHGHGRFDPGGATAMSGSVDRNTAHRYLEHEFFKGNHRRSLDRGDFAIPAKGELNLADGARTLAFVSAAAILKSASHLPARPRTYVVSGGGRKNGALMDELTALAEREGAHVIDADNAGFDGDAMEAEAWAYLAVRSLCGLPLTYPSTTGCDKPVSGGVPVRP
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: HUTU_SALDC
Sequence: MPESKYRQQTIRAPRGTVLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARNWECYDAIVDALTRLEADETLLIQSGKPVGVFKTHDNAPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGCQHYNGTLAGRWVLTAGLGGMGGAQPLAATLAGACSLTIECQQSRIDFCLRTRYVDEQAATLDDALARITRYTREGKAVSVALCANAADILPELVNRGVRPDLVTDQTSAHDPLHGYLPSGWRWEEYQKNAQSDPHGTMQAAKRSMAAHVRAMLAFSKMGVPTFDYGNNIRQMAKEMGVENAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPQDIYKTDAKVKEIVAEDKHLHHWLDMARERIHFQGLPARICWVGLEWRQKLGLAFNEMVRCGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHAGMVIVCDGTDEAAARIRRVLHNDPATGVMRHADAGYDLAVECAVEQGLNLPMVAATQGKG
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.