PharMolix/UniProtQA huggingface dataset:
Protein: ILVD_BUCBP
Sequence: MPKYRSSTTTQGPNMSGARALWRATGMSSDDFNKPIIAVVNSFTEFVPGHIHLRELGQLVSQYIISSGGVSKEFNTIAIDDGIAMGHSGMLYSLPSRDLIADSVEFMINAHCVDAMVCISNCDKITPGMLMAALRLNIPCVFVSGGPMESGKIVISDKEIKLNLVDAITCGVNPDSSDDMINEIEKSACPTCGSCSGMFTANSMNCLMEAIGLSLPGNGTILATHIDRKKLFVQAGKLIVKITQEYYKNNNEKFLPRNVATKEAFCNAMALDIAMGGSTNTVLHLLAAAREGCVDFTMLDVDLLSRKIPNLCKLSPNTTFYHIEDFHRAGGVFGVLDELNKVNLLYKQTFNILGLNLEEMLSKYSILTGNDKNIIKMFYAAPSGQKTIKPFSQSCRWNSLDIDRKLGCIRDYNSAFSLDGGIAVLYGNLAKDGCIVKTAGVHEKNLIFRGKAVVYESQDEAVHAILNNKIVKGNVIIIRYEGPKGGPGMQEMLYPTSYLKSMKLDQDCALITDGRFSGGTSGLSIGHISPEAANQGIIALVRTGDFIDINIPNRKIHLDITDNELLLRIKNEKDRGIDAYTPSHRKRIVTSALKLYSKFVTSADKGAVRNIR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: OPPF_MYCGE
Sequence: MENQNTKKPLVNVKALSMMFKVRGTLFKALDEIGFTVNEGDFFGVIGESGSGKSTTGKCLIRLNIPSGGKIEIANHLLSGKKLTKENNQWLKQNIQMVFQDPYSSINPTKNVLTVISEPLVISKTVFGETKQYLKSLQKLSFKVKKTLLRNDIELETKFHNNFFKTVIKQINESLFNFEDLDYKDLKPSHLRQRIINETDKFIEKIRSEFALFYDFYANQSVPLQKALDDANSSLTPSSVIELKNQLKALQKQAKISKAAWDILQALKQNQKELKDYENYVHFELQKKPRIYLNTWLLTTKSYIKDSKQNMQLTDDIFAFSYNSMVDKKRNLVLILSKYYKLLPYFYDQSVFDNADQFDEIANLIFFDLVETLLGVTSLFNDALAADKVPLIKFAKFLNKLCDLRFLTLKKSFKKTRVSCSFSFNSEPEILFANSCYDLQQMPQIIKPFWEKLFNEQNYQKIIDSVSRLNVMIANYITKAFEIKKTIDEKLREFKQQNLALKKAYSANKKSEANKASINELKVNLKTLKKQLKQEKNTTKKQSKKELKPLLKEHHTALKLHDEFNHDLRKWFKKLNFMVKKYNRLENSQKKFCLVKKLKALFKKQDETLQSELRPKLKTFGVINFEYKRAVKESNVFRLVHFAKNIFKPFLFFNLTKIFMRNKVYEALDSVGLKREHAYRYPHEFSGGQRQRIAIARALITKPKLIIADELISALDVSIQAQVINILKDLAKKHNLTVLFIAHDLSMVQTVCNRLIIMHRGKIVERGSVDEIFSNPVHPYTRSLIKASPKLSKINVDLASFDENFTYDSDYSLTNMPFYIKVPNSEEHELYCTQKQFDSWIKEATPIN
What is the function of this protein?
Part of the binding-protein-dependent transport system for oligopeptides.  Probably responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Oligopeptide transport ATP-binding protein OppF.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UVRC_BACMK
Sequence: MHEHLKEKLAILPDQPGCYLMKDKQGTVIYVGKAKVLKNRVRSYFTGSHDGKTLRLVGEIVDFEYIVTSSNLEALILELNLIKKYDPKYNIQLKDDKTYPFIKITAEKQPRLLITRNVKKDKGKYFGPYPNAQSAHETKKLLDRMYPLRKCSNMPDKVCLYYHMGQCLAPCVKEVTDEQNKEIVDEIIKFLNGGHKEIRSELETKMYEASEKLEFERAKELRDQIAHIDAIMEKQKMIMSDLVDRDVFGYAVDKGWMCVQVFFVRKGKLIERDVSMFPIYDEPEEGFLTFIGQFYENSSHFKPKEIVVPGSIDSELVERFLEVEATQPKRGKKKDLVELANKNAKIALEEKFHLIERDEERTVKAIDNLGKQLGIETPYRIEAFDNSNIQGTNPVSAMIAFIDGKPAKKEYRKYKIKTVQGPDDYESMREVVRRRYTRALKENLPLPDLIIIDGGKGHLAATSDVLENELGLYIPMAGLVKDDKHKTSHLIIGDPPEPVMLERNSQEFYLLQRIQDEVHRFAITFHRQLHGKSVIQSALDDIPGIGDKRKKVLLKHFGSLKKMKEASIAEFVEAGMPKNVAEMIYTYLTDKKTL
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPY1_HUMAN
Sequence: MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQIKAIRGSNEYTEGPSVVKRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVLPSNARGPILSRSTSTGSAASSGSNSSASSEQGLLGRSPPTRPVPGHRSERAIRTQPKQLIVDDLKGSLKEDLTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDEGDSYSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDWIHRPGCRCKNSNTVYCKLESCPSRGQGKPS
What is the function of this protein?
Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity).  Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
What are the official names of this protein?
Protein sprouty homolog 1, Spry-1.
What is the protein family that this protein belongs to?
Belongs to the sprouty family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
Protein: NHAA_YERPA
Sequence: MTNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGVYQSFLDIPVSIKIASLDISKPLLLWINDGLMAVFFLMIGLEVKRELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALAIIDDLGVIIIIALFYTQQVSLQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLHTQDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGKPLGIFTFSWLAVKLGIAKLPDAINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTYSKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BLAB3_ELIME
Sequence: MLKKIKISLILALGLTSLQAFGQENPDVKIEKLKDNLYVYTTYNTFNGTKYAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIINIATHSHDDRAGGLEYFGKIGAKTYSTKMTDSILAKENKPRAQYTFDNNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQTSIQHTLDLISEYQQKQKASN
What is the function of this protein?
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
What are the official names of this protein?
Metallo-beta-lactamase type 2, B2 metallo-beta-lactamase, Beta-lactamase type II, Carbapenem-hydrolyzing beta-lactamase BlaB-3, CHbetaL-3, Class B carbapenemase BlaB-3, Metallo-beta-lactamase type II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SFH1_ASHGO
Sequence: MSQLLPQAYLTNFHNRIRNEDVPLFITAAPTRNHKRAKVVNYSEYDNDLLLDDFIEQDQNDDDEKVHSDNGKGEGEEVGHEDAVASNNNLPDLEQQDDPTGILRYPRIRETFLQSKIAVRYEQVLEAGVGGSGEAVGIAEDEGAGAYSSSSQPVVIPIRLNLEHNGHKIIDFFTWNLNDHSLTLEQFAQIYCQDLDFAHNLSLQNQIVAAINDQLQEYETLASVVVPDLHVIINLTCNLDSKLYEDNFEWNLNDQTLSPEQFAELVVQDLGLTREFMPAIAHALYESILKIKKDWLEGHLNPEHVANGAAFGCLSGIRLDIDTLGSNWCPKVEVLSQWEIEKREIEKERNMRRLKRESAKVDDRLARRRGKRRMDDLETTMRI
What is the function of this protein?
Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning.  RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA.  The reaction requires ATP and involves an activated RSC-nucleosome intermediate.  Remodeling reaction also involves DNA translocation, DNA twist and conformational change.  As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.  This subunit is essential for mitotic growth and required for cell cycle progression (By similarity).
What are the official names of this protein?
Chromatin structure-remodeling complex subunit SFH1, RSC complex subunit SFH1, SNF5 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the SNF5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MATK_POTAN
Sequence: MEDFQVYFELYRSQQHDLLYPLIFRESIYALAHDRGLNRSVLLDNVGYDKKASLLIIKRLISRMYQQNRFIISFNDSNQNKFLGYNKNLYSQMISEGFAVIVEIPFSLRLVSSLEETETVKSYNLRSIHSIFPFLEDKFPHLNYASDVLIPYPIHLEILVQTLRYCMKDPSSLHLLRLFLYEYYSWNTVITPKKSLFAKRNQRLFLLLYNSYVGEYESILLFLRNQSNHLRLTSFRIFFERIRFYEKIKYPVEEVLFPATLWFFKDPFIQYVSYQGKSILASKDTPLLMTKWKYYLVNFWQCHFYVWSQPGRIHINQLFKYSFDFLGYLSSIRPNISVVRSQLLENSFLMNNLMKKLDTLFPTIPMIGSLAKVKFCNTLGHPISKSSWADLSDSDIIGRFVRIGGNLSHYYSGSSKKKSLYRIKYILRLSCVKTLARKHKSTVRTFLKRLGPKLLDEFFTEEEQVFALLFPRTSSTSKRLYRGQIWYLDILCINDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NRDR_CALS4
Sequence: MKCPYCGYPDSRVIDSRPTDDNTAIRRRRECLKCGKRFTTYEKVEQLPILVIKKDNRRELYDKEKILRGMIKACEKRPVPIKVLEEITDEIDRKIVNSMVREITSAEIGEMVMEKLKSVDEVAYVRFASVYRQFKDINTFMDELKKLLKENEEKKQKE
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: ADA30_HUMAN
Sequence: MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRPKAKSVKKQKK
What is the function of this protein?
Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034).
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 30, ADAM 30.
What are the subcellular locations of this protein?
Late endosome membrane; Single-pass type I membrane protein.
Protein: RARGA_DANRE
Sequence: MFDCMEALGMGPRQLYDVTNRGACMLRKASPFYAGLDPFAWTGTASVRSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCQDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCQINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKDVKDEVIPPESYELSGELEELVNKVSKAHQETFPSLCQLGKYTTNSSSDHRIQLDLGLWDKFSELSTKCIIKIVEFAKRLPGFTTLTIADQITLLKSACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPERVDRLQEPLLEALKIYARRRRPNKPHMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEAFEDQSESTEKKPEPEPPAPPPPALLTMKKEQEDEDDSWATENGSEPSPEEEDDDDEDGEEERGTDSDGEAWGGQEPNADVSRKSHGGRAQ
What is the function of this protein?
Receptor for retinoic acid.  Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.  The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity).  Required for hindbrain development and for the development of pharyngeal arches.
What are the official names of this protein?
Retinoic acid receptor gamma-A, RAR-gamma-A, zRAR gamma, Nuclear receptor subfamily 1 group B member 3-A, RAR-gamma-2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIAS_VITVI
Sequence: MYTRLSSLALRHHRHNHNNSVLLLSSLISLRHCSSPPTNPEPPQTLASLRHRLAVESPSLSDFVRLQTSDDYSVEVGTKKKPLSKPKWMKESIPGGAKYTQIKKKLRQLNLHTVCEEARCPNMGECWSGGETGTATATIMILGDTCTRGCRFCNVKTSRTPPPPDPDEPSKVAEAIASWGLDYVVITSVDRDDLPDQGSGHFAETVQKLKILKPNMLIEALVPDFRGDPGCVEKVSKSGLDVFAHNIETVEELQSAVRDHRANFKQSLEVLKLAKEYADAGTLTKTSIMLGCGETPDQVVRTMEKVRAAGVDVMTFGQYMRPSKRHMPVSEYITPEAFEKYRILGMDMGFRYVASGPMVRSSYKAGEFYIKSMIDADRAMSWASSSPSPLPAA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PYIE_MAGGR
Sequence: MHKFFPRSGFFDFETVRILGTACYGGADVAEVLEAVGEIKSDDAASWEEAWRRQSWWAEALADQAREGGDREAARRAYLRASNYARASGYMYVSDLGAEGGNAPPTQDPRALPVAEKVGRLFRKALALMEGEVRALSIPCGAQALPGLLYLPPPGKRIPGRDKIPVLVFLGGADSCQEELYYLYPAAGPGLGYAVLTFDGPGQGIVLRKHGLRVRPDWEVVTSSVLDYLEAYSAQHPGLELDMKAIAVSGASMGGYYALRSAVDRRVKACVSIDPFYDMWDFGTAHVSPLFISAWTSGIISSGFVDKLMTVVSRLWFQMKWEIALTGTLFGLSSPSQILLNMKNYTLSGKSDGSRANGKKSHSPTDGGGVESDSFLSEVRCPVFLSGAGKSLYLDVDSHTRRCYDGLTGVAAKDKELWVPESEGQGSLQAKMGALALCNQKTFQFLDKVLGVQRVPLDVSAHI
What is the function of this protein?
Hydrolyase; part of the gene cluster that mediates the biosynthesis of the mycotoxin pyrichalasin H, a tyrosine-derived cytochalasan that inhibits the growth of rice seedlings, but also inhibits lymphocyte capping and actin polymerization and alters cell morphology (PubMed:31099577) (Probable).  Pyrichalasin H is indicated as the responsible agent for the genus-specific pathogenicity of M. grisea toward crabgrass (PubMed:31099577).  The first step in the pathway is catalyzed by the O-methyltransferase pyiA which methylates free tyrosine to generate the precursor O-methyltyrosine (PubMed:31099577).  The hybrid PKS-NRPS pyiS, assisted by the enoyl reductase pyiC, are responsible for fusion of the O-methyltyrosine precursor and the polyketide backbone (PubMed:31099577).  The polyketide synthase module (PKS) of pyiS is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the O-methyltyrosine precursor (PubMed:31099577).  As the NRPS A-domain demonstrates substrate tolerance, pyiS can also use phenylalanine, tyrosine and even para-chlorophenylalanine as amino acid precursor, which leads to the production of novel cytochalasans, including halogenated cytochalasans (PubMed:31099577).  Because pyiS lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase pyiC (PubMed:31099577).  Reduction by the hydrolyase pyiE leads to 1,5-dihydropyrrolone, which is substrate for dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase pyiF to yield the required isoindolone-fused macrocycle (PubMed:32039410).  The tailoring cytochrome P450 monooxygenases piyD and piyG catalyze the hydroxylation at C-18 and C-7, respectivily, whereas the short-chain dehydrogenase/reductase pyiH reduces the carbonyl at C-21 in preparation for the transfer of an acetyl group by the acetyltransferase pyiB (PubMed:31099577).  These 3 reactions whose order is not clear yet, lead to the production of O-methylpyrichalasin J, a deacetylated pyrichalasin H (PubMed:31099577).  Finally, pyiB to converts O-methylpyrichalasin J into the final product pyrichalasin H via acetylation of C-21 (PubMed:31099577).
What are the official names of this protein?
Hydrolase pyiE, Pyrichalasin H biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.
Protein: TSAD_STAES
Sequence: MTNNKLILAIETSCDETSVSVIKNGTELLSNTVLSQIDSHKRFGGVVPEVASRHHVEGITATIDESLVSAKVKMEDIDAIAVTQGPGLIGALLIGINAAKALAFAYDKPIIPVHHIAGHIYANHLEQPLTFPLMSLIVSGGHTELVYMKNHLDFEVIGETRDDAVGEAYDKVARTINLPYPGGPHIDRLAAKGKDVYDFPRVWLEKDSYDFSFSGLKSAVINKLHNLRQKNIEIVAEDVATSFQNSVVEVLTYKAIHACKTYNVNRLIVAGGVASNKGLRNALSEACKKEGIHLTIPSPVLCTDNAAMIGAAGYYLYQAGLRGDLALNGQNNIDIETFSV
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOC_METCA
Sequence: MNSLPRPDIGPFADTPEKRWVGVSFGAAAVGYDGVAALQREVGESLLAGIRHLGPPPARMLDLGAGTGHFSGLLVAAFPTAECLALDIAEGMLRFLRSHRPGADGMGLVVGDAEALPLADESVDLIFSNMAFQWCERLDRAISECCRVLRPGGRLAFSTFGEATLAELRMAWRAVDGYTHVNAFATRRSVEQELRAQGFTKIRLDARTLRRGYPSVLALMKELKALGARNLTRNRPRHLLSRHTLERVSEAYGRLPGMASAVTASFEVLTALVEK
What is the function of this protein?
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM).  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
What are the official names of this protein?
Malonyl-[acyl-carrier protein] O-methyltransferase, Malonyl-ACP O-methyltransferase, Biotin synthesis protein BioC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: EBP2_DROME
Sequence: MSDFEMEDSASGYDSGDNSDAELQAAFERGDLKPGLNVEFNGQRDKVNDVTKLLAKTEAIKMQLPWLERLDMINTLAPLAPELAVQLEKHEQKRANLFKGNAKLPYIRPEEDPVLNDFKREMLFHRQAQSAVLEAIPRLHELGIKTRRPDDYFAEMAKSDEHMQKVRANLMAKQQGQAKSERIKQIREQRKMGKMLAKQTKVQREAEKKDMLDKLKKFRKGKLKNLDFLEDAKALESKQKQSAENRKKRNKKFGFGGKKKGLKRNTKSSSAGLDGDKSSRRQRGVKAGASVNKRLGKSRRIKAKGRK
What is the function of this protein?
Required for the processing of the 27S pre-rRNA.
What are the official names of this protein?
Probable rRNA-processing protein EBP2 homolog.
What is the protein family that this protein belongs to?
Belongs to the EBP2 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CLPP_HALOH
Sequence: MSLIPVVVEQTNRGERSYDIYSRLLKDRIVFLGHPINDELSNLIIAQLLFLEAEDPDKDIHLYINSPGGSVTAALAMYDTIQYIKPDVATICMGQAASAGALLLASGTKGKRYALPNARVMIHQPAGGVQGKATEAEIHIKELLRLRERLNEILSKHTGKSVEQISKDVEQDYFMTAEEALEYGIIDEVITKNELKDK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_ECO5E
Sequence: MAMTYHLDVVSAEQQMFSGLVEKIQVTGSEGELGIYPGHAPLLTAIKPGMIRIVKQHGHEEFIYLSGGILEVQPGNVTVLADTAIRGQDLDEARAMEAKRKAEEHISSSHGDVDYAQASAELAKAIAQLRVIELTKKAM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYE2_BRUAB
Sequence: MSKPVITRFAPSPTGYLHIGGARTALFNWLYAKHCGGKMLLRIEDTDRERSTEAATAAILDGLTWLGLDWDGEAISQFERAPRHREVAEELVANGKAYYCYASPEELEEMREKARAEGRPPRYDGRWRDRDPSEAPAGVKPVIRIKAPRDGETVVHDAVQGDVRFPNKDLDDFIILRSDGTPTYMHAVVVDDHDMGVTHIIRGDDHLTNAARQTIIYNAMGWDVPQMSHIPLIHGADGAKLSKRHGALGVDAYRAIGYLPAALRNYLVRLGWSHGDDEIMSTEQMIEWFDVKDINKGAARFDFQKLEAINGLYMRSSDDQALFDALVAVLPEIEGGKELAEALDDKGRAQLLLAMPGLKERAKTLVELADGAKFIFASRPLALDEKAASLLNDEGRAVLKPVYPVLEAVGEWTAESLDAAIRAHAEAEGLKLGKIAQPLRAALTGRATSPGVFDVLVVLGREESLARIGDQIG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_FRATO
Sequence: MIETDRIISANTAQTNDENVIDRAIRPKTLAEYEGQPAVREQMEIFIQAAKARKDALDHTLIFGPPGLGKTTLSNIIANEMGVELKQTSGPVLEKAGDLAALLTNLEENDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLVGATTRAGLLTSPLRDRFGIIQRLEFYSIDDLSKIVYRSAKLLNLDITTDGAMEIAKRSRGTPRIANRLLRRVRDYAQVKGSGVICFEIADKALSMLKVDPVGFDHMDHRYLLTLMEKFAGGPVGLDTMSAALSEEKGTIEDVIEPYLIQQGYIMRTARGRIATLLAYNHFKLKIPDNLSADQQQTLSI
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: NHAA_FRACC
Sequence: MGQVPSRRFSLFDRRSWPEARRIAEILRREAIGGGLLLAATVLALGWANSPWSESYQSMLSYQLGPSWAHLDLTLAQWAADGLLAIFFFVAGLELKREFIAGDLRDPRRAAVPVLAACGGVAVPAVLYALVNVGGDASAGWAIPTATDIAFALAVLAVIGRHLPSGLRTFLLTLAVVDDLLAIVIIAVVYTRHLSILPLLGALVPLALFTLLVQRRVRSWWLLLPLAAATWTLVHASGVHATVAGVLLGFAVPVLRGTRAGGPEAGPGLAEHFEHRWRPLSAGVAVPIFAFFSAGVTVDGLSGLSAALSDRAALGVVLGLVVGKPLGIMAATFLVARFTRATLDDGLTWTDVLGLAVLAGIGFTVSLLIGELAFGSGSARDDHVKIAVLTGSLLAALLAAVVLRLRNRVYRRLQEAETADRDHDGIPDVYQDLHRSSPRPWG
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.