PharMolix/UniProtQA huggingface dataset:
Protein: AGAP2_HUMAN
Sequence: MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAVGAPGARGSEPRDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGAGGAEPPALSPAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATAAAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPPAGSPPPLTLPPTPSPATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV
What is the function of this protein?
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity.  Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity.  It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase.  Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt.  It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system.  It seems to be oncogenic.  It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
What are the official names of this protein?
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, AGAP-2, Centaurin-gamma-1, Cnt-g1, GTP-binding and GTPase-activating protein 2, GGAP2, Phosphatidylinositol 3-kinase enhancer, PIKE.
What is the protein family that this protein belongs to?
Belongs to the centaurin gamma-like family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: DAPF_PSEU2
Sequence: MLLRFTKMHGLGNDFMVLDLVSQHAHILPKHAKQWGDRHTGIGFDQLLLVEAPNNPDVDFRYRIFNSDGSEVEQCGNGARCFARFVLDKRLTAKKQIRVETKSGIIELDIRSDGQISVDMGPPRFVPEEIPFEAAEQATCYTVDVDGQHVDMAAVSMGNPHAVLRVDDINNAPVHELGPKIEHHPRFPARVNVGFLHVVDRQRAQLRVWERGAGETQACGTGACAAAVAAISQGWMDSPLLIDLPGGRLSIEWAGPGHSVMMTGPAVRVYEGQVRL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIFK_SACS2
Sequence: MEDDKLIVRIISKEGEIIRLTEEGERFLSSCLSSLKDAILSLHSIEIKGNIVSGLGEGKIFLSMEYYKSQINKIMGFDPFPGTLNIVIYDKASLENRLLLDSSPSLMVPEYKQKDRVLGAVKLYPAAINKLTPAAVVIPLRTTHPKSVIEIISPFHLREKLNLKDGDEVTIEVYV
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: CCM2_DANRE
Sequence: MEEDVKKVKKPGIVSPFKRVFLKGEKGRDKKALEKSTERRALHTFSLSLPDHRIDPDILLNDYIEKEVKYLGQLTSVPGYLNPSSRTEVLQLIDNARKSHQLAGQLTSEQDAVVSLSAYNVKLVWRDGEDIILRVPIHDIAAVSYIRDDSLHLVVLKTAQEPGGSPCHSTEMSKSPTLSSLSESGAVLVEVCCLLVLAVDNKAAAEELCLLLSQVFQIVYTESTIDFLDRAIFDGATTPTRHLSIYSEDSSSKVDVKDVFEAEASTFSFQSSLEAGHSSSPSPTSAPASPQTKTASESELSTTAAELLQDYMTTLRTKLSSKEIQQFATLLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYKRTTSSASDSTTNGNGAAGGSDEGTATSEGDEWDRMISDISNDIEALGSSMDQDGVPS
What is the function of this protein?
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity.  May act through the stabilization of endothelial cell junctions.  May also function as a scaffold protein for MAP2K3-MAP3K3 signaling.  Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
What are the official names of this protein?
Cerebral cavernous malformations protein 2 homolog, Malcavernin, Valentine.
What is the protein family that this protein belongs to?
Belongs to the CCM2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB1_ACICJ
Sequence: MNAVQQPDIAWNRDHLDPGAEQEAVIRGITGEIAGKGFVVANLDRLVNWARTGSLWPMTFGLACCAVEMIHAYMPRWDLDRFGIIPRNSPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALVYGITQLQKKIRRTGTIFRE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 1, NADH dehydrogenase I subunit B 1, NDH-1 subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACH2_LONAC
Sequence: IVGGSTTTIASYPEITALLYFNRQACGGTILNNRSVLTAAHCPFGDAASSWSFRVGSTNANSGGTVHSLSTFIIHPSYNRWTLDNDIAIMRTASNINFINNAVRPGSIAGANYNLADNQVVWAAGWGTTSPGGSLARFPGVNARHVQIWTVNQATCRTRYASIGHTVTDNMLCSGWLDVGGRDQCQGDSGGPLYHNGVVVGVVSRYTAWIQSNA
What is the function of this protein?
Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains.  Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.
What are the official names of this protein?
Achelase-2, Achelase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: ANO9_MOUSE
Sequence: MQDDESSQIFMGPEGDQLPLVEMGSCKPEASDQWDCVLVADLQTLKIQKHAQKQLQFLENLESNGFHFKMLKDQKKVFFGIRADSDVIDKYRTLLMNPEDSGSRDEQSFNIATTRIRIVSFVVNNKLKPGDTFEDLVKDGVFETMFLLHKGEQNLKNIWARWRNMFEPQPIDEIREYFGEKVALYFTWLGWYTYMLVPAAVVGLIVFLSGFALFDSSQISKEICSANDIFMCPLGDHSHRYLRLSEMCTFAKLTHLFDNEGTVLFAIFMALWATVFLEIWKRKRAHEVQSWKLYEWDEEEEEMALELINSPHYKLKDHRHSYLSSTIILILSLFMICLMIGMAHVLVVYRVLAGALFSSLVKQQVTTAVVVTGAVVHYIIIVIMTKVNKYVALKLCKFEESGTFSEQERKFTVKFFILQFFAHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHLSGCMMDLFIQMAIIMGLKQTLSNCVEYLCPLLAHKWRLMWASKHGHMSKDPELKEWQRNYYMNPINTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVRLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYHYGPCRTNRTFTDDCLTNYVNHSLSVFYTKHFNDHSRMEGQENVTVCRYRDYRNEHDYNLSEQFWFILAIRLTFVILFEHFALCIKLIAAWFVPDVPQKVKNEVLQEKYDRIRHRMRFSSRSTDV
What is the function of this protein?
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839).  Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity).  Can inhibit the activity of ANO1 (By similarity).
What are the official names of this protein?
Anoctamin-9, Transmembrane protein 16J.
What is the protein family that this protein belongs to?
Belongs to the anoctamin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Protein: PSBF_CHLRE
Sequence: MTTKKSAEVLVYPIFTVRWLAIHGIAVPTIFFLGAITAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y025_BORHD
Sequence: MSGHSKWSTIKRKKGALDAKRNKIFTKLIREISIAAKMGGGDIDSNPRLRLAINKARVSNMPKDNIEKAIKKGIGDNTGAEYFELTYEAYALHGVALIIKCLTDNKNRTASEVRSVLSKNGASLGAPGSVSYMFHKKGLISYSLDKYPEDEIMELALEAGAEDIYSEGSQIEVITSAETFEAISSVLRTKFEEDIAEIALLPENKISLNKEQIDKVLSLIEKLEDFDDVQEVVHNLEIIDEID
What are the official names of this protein?
Probable transcriptional regulatory protein BH0025.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAGA1_HUMAN
Sequence: MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQGASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAREPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYDGLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLTQDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREAALREEEEGV
What is the function of this protein?
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1.  May inhibit notch intracellular domain (NICD) transactivation.  May play a role in embryonal development and tumor transformation or aspects of tumor progression.  Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
What are the official names of this protein?
Melanoma-associated antigen 1, Antigen MZ2-E, Cancer/testis antigen 1.1, CT1.1, MAGE-1 antigen.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MYBY_DICDI
Sequence: MSDLREINRLNKDEEFEYFKLYSNSNGFRKWNLDEHNIFSKASLEYNFLKPDQMIEILKLVNQHNSNTSCKARTLEELNIHIKVYQNFLNKQQALRSPTTGSLNISGFGNPITSGGGGLGVLGGGGGGGGISSSSLGGLSGSGLFLNTMVNNTFQTILDSLDGNSSNNNNNNIPSTSSVKDVVSIGINPLFQKSVQSQSQLPTATNNNNKQPLELISKPIPTATATATTTATTTTTTIQPPIGGTKNTVNKEIEQDSNDNDNNNNTNNNNNNNNNNNNNNNNEEKEKQYLNYINNSLGELNKKDLKLLNEPWTVEDQKKLEDALTKYPPSRFSSVSRWQMVSKELGISPKAVALRYNQMLNQLIPKKPSLQQQQQQQQQQQQQPTTTTTTTTKPEQSIKSEEEEQTTGKRKSRSSFSSPSSSSKESPNKKEKTTHDTTTTTNTATTTTVTPNMTTPSIINSSPAIAANLLEADSLLQKNNQLLKQIRTSVMQLTDPQSTILTEVIENINNSIQLTGKWKDNIEMPPLPLKVNDLILSLISNNTSSSFKKPLSKKVTEWNLVVEDDAPTQDKK
What are the official names of this protein?
Myb-like protein Y.
Protein: NTM1A_DANRE
Sequence: MEDCLIEDQTSFYSEAEHYWKDVPPTVDGMLGGYGSISSIDINGSKKFLQKFLGEGQGKTGTGCALDCGAGIGRITKRLLLPLFRTVDLVDVTQEFLDKARTYLGEESKRVENYFCCGLQDFQPQPERYDVIWIQWVIGHLTDDHLVEFLRRCRSGLRPEGLIVVKDNVAYEGVIPDDVDSSVCRDLNVLHRLVARAGLSIIYEEQQQNFPEEIYQVHALALR
What is the function of this protein?
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved.  Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif.  Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on target proteins.
What are the official names of this protein?
N-terminal Xaa-Pro-Lys N-methyltransferase 1, Alpha N-terminal protein methyltransferase 1A, Methyltransferase-like protein 11A, X-Pro-Lys N-terminal protein methyltransferase 1A, NTM1A.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. NTM1 family.
What are the subcellular locations of this protein?
Nucleus. Note=Predominantly nuclear.
Protein: CATS_RAT
Sequence: MAVLGAPGVLCDNGATAERPTLDHHWDLWKKTRMRRNTDQNEEDVRRLIWEKNLKFIMLHNLEHSMGMHSYSVGMNHMGDMTPEEVIGYMGSLRIPRPWNRSGTLKSSSNQTLPDSVDWREKGCVTNVKYQGSCGSCWAFSAEGALEGQLKLKTGKLVSLSAQNLVDCSTEEKYGNKGCGGGFMTEAFQYIIDTSIDSEASYPYKAMDEKCLYDPKNRAATCSRYIELPFGDEEALKEAVATKGPVSVGIDDASHSSFFLYQSGVYDDPSCTENMNHGVLVVGYGTLDGKDYWLVKNSWGLHFGDQGYIRMARNNKNHCGIASYCSYPEI
What is the function of this protein?
Thiol protease.  Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation.  The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
What are the official names of this protein?
Cathepsin S.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome. Secreted. Cytoplasmic vesicle, phagosome.
Protein: AGAL_MOUSE
Sequence: MKLLSRDTRLVCELALCPLALVFWSILGVRALDNGLARTPTMGWLHWERFMCNLDCQEEPDACISEQLFMQMAELMVSDGWRDAGYDYLCIDDCWMAPERDSKGRLQADPQRFPSGIKHLANYVHSKGLKLGIYADVGNKTCAGFPGSFGSYDIDAQTFADWGVDLLKFDGCHCDSVVSLENGYKYMALALNRTGRSIVYSCEWPLYLRPFHKPNYTDIQYYCNHWRNFDDVYDSWESIKNILSWTVVYQKEIVEVAGPGSWNDPDMLVIGNFGLSWDQQVTQMALWAIMAAPLLMSNDLRQISSQAKALLQNKDVIAINQDPLGKQGYCFRKENHIEVWERPLSNLAWAVAVRNLQEIGGPCPYTIQISSLGRGLACNPGCIITQLLPEKVHLGFYEWTLTLKTRVNPSGTVLFRLER
What is the function of this protein?
Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.
What are the official names of this protein?
Alpha-galactosidase A, Alpha-D-galactosidase A, Alpha-D-galactoside galactohydrolase, Galactosylgalactosylglucosylceramidase GLA, Melibiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: SDCS_STAAW
Sequence: MAYFNQHQSMISKRYLTFFSKSKKKKPFSAGQLIGLILGPLLFLLTLLFFHPQDLPWKGVYVLAITLWIATWWITEAIPIAATSLLPIVLLPLGHILTPEQVSSEYGNDIIFLFLGGFILAIAMERWNLHTRVALTIINLIGASTSKILLGFMVATGFLSMFVSNTAAVMIMIPIGLAIIKEAHDLQEANTNQTSIQKFEKSLVLAIGYAGTIGGLGTLIGTPPLIILKGQYMQHFGHEISFAKWMIVGIPTVIVLLGITWLYLRYVAFRHDLKYLPGGQTLIKQKLDELGKMKYEEKVVQTIFVLASLLWITREFLLKKWEVTSSVADGTIAIFISILLFVIPAKNTEKHRRIIDWEVAKELPWGVLILFGGGLALAKGISESGLAKWLGEQLKSLNGVSPILIVIVITIFVLFLTEVTSNTATATMILPILATLSVAVGVHPLLLMAPAAMAANCAYMLPVGTPPNAIIFGSGKISIKQMASVGFWVNLISAIIIILVVYYVMPIVLGIDINQPLPLK
What is the function of this protein?
Mediates the transport of the dicarboxylates fumarate, malate, and succinate across the cytoplasmic membrane via a Na(+)-electrochemical gradient.
What are the official names of this protein?
Sodium-dependent dicarboxylate transporter SdcS, Na(+)/dicarboxylate symporter.
What is the protein family that this protein belongs to?
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RHP26_SCHPO
Sequence: MSVNEDLSHLGVFSVDQENLERDVTNTASEYIAHESREIEKKRLQKVRKEISSVKEKIRRLDERIDSRLTKISVKENFRKQLSKFRDTLQSLQSDENDIKRRLNNEDSANAPGIGAFSTEELERQELIRTGKVTPFRNLSGLQKEVDFDDESSIREAVIKSEGTYYETAPHLSSEPSNIDHGIIPRDEKDEYVTVDAVTEKVVTAAIDDGDDLVYRQRLNAWCANRKELRDQASASENNKDRGEFEGKDEWLLPHPSKKGQTFEGGFTIPGDIRPHLFRYQVTCVQWLWELYCQEAGGIIGDEMGLGKTIQIVSFLSSLHHSGKFQKPALIVCPATLMKQWVNEFHTWWAPLRVVVLHATGSGQRASREKRQYESDASESEAEESKTSIKLRGASSSFHRYAKNLVESVFTRGHILITTYAGLRIYGDLILPREWGYCVLDEGHKIRNPDSEISISCKQIRTVNRIILSGTPIQNNLTELWNLFDFVFPGRLGTLPVFQNQFALPINIGGYANASNVQVQTAYKCACMLRDLISPYLLRRMKLDVAADLPKKSEQVLFCKLTPLQRKAYQDFLQGSDMQKILNGKRQMLYGIDILRKICNHPDLVTREYLLHKEDYNYGDPEKSGKLKVIRALLTLWKKQGHRTLLFSQTRQMLDILEIGLKDLPDVHYCRMDGSTSIALRQDLVDNFNKNEYFDVFLLTTRVGGLGVNLTGADRVILFDPDWNPSTDAQARERAWRLGQKKDVVVYRLMTAGTIEEKIYHRQIFKQFLTNKILKDPKQRRFFKMTDLHDLFTLGDNKTEGTETGSMFLGSERVLRKDNSSRNGNEAEDIPARDRKKHKIHDKGKKVNSSKVFEKMGIASMEKYKPPQESNVTKTNSDSTLGDDSVLDDIFASAGIQSTLKHDDIMEASQTESILVEKEATRVANEALRAVSSFRRPPRQLIPPQQSTNVPGTSKPSGPITSSTLLARLKQRR
What is the function of this protein?
Involved in transcription-coupled repair (TCR).
What are the official names of this protein?
DNA repair protein rhp26, RAD26 homolog.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RLME_RHIE6
Sequence: MTKAPIAGNRTGRKLGQRVKNKKMKASSRQWLQRHINDPYVQRAQLEGYRARAAFKLLEIDEKYHILRGARRIIDLGAAPGSWSQIAAKVTGSTDEDIRVAAIDFLEMAQLPGVKILQLDFLDPSAPEKLMEAVGGTPDLVISDMAAPTTGHHRTDHLRTMHLCEVAAHFAIEVLGEGGHFLTKTFQGGTERDLLAMLKQNFRQVVHVKPNSSRAESVEMFLLAKGFKGRKAEGHAEEA
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA1B_CONVE
Sequence: ASDGRNAAADDKASDPIALTVRGGCCSHPVCYTKNPNCGGRR
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (PubMed:31255696).  This toxin potently and selectively inhibits human and rat alpha-6-beta-4/CHRNA6-CHRNB4 nAChR (IC(50)=12 nM on rat nAChR) (PubMed:31255696).  It exhibits rapid binding and unbinding at this receptor (PubMed:31255696).  It also shows activity on rat alpha-6-beta-4/CHRNA6-CHRNB4 (IC(50)=12 nM), human alpha-6/alpha-3-beta-4 (CHRNA6/CHRNA3-CHRNB4) (IC(50)=5. 3 nM), rat alpha-6/alpha-3-beta-4 (CHRNA6/CHRNA3-CHRNB4) (IC(50)=18 nM), rat alpha-3-beta-4/CHRNA3-CHRNB4 (IC(50)=320 nM), and rat alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=4 uM) (PubMed:31255696).
What are the official names of this protein?
Alpha-conotoxin VnIB.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NADB_XYLFA
Sequence: MAEIVDCFADRPIIVGSGLAGLIAALTMSPEPSVLVTRSALGAETSSAWAQGGMSVSLSPDDNPSLHLADTLAAGDGLCDAVAAESIILEALDAFHVLQHFGIHFDQDSNGHLALGLEAAHSRRRIVHVGGDRSGTAIVQALTACVLNDPSITVLEGLEARHILMADNVVCGLLLANPTSEIVLPSSRILLATGGIGGLYDATTNPVSNFGQGIAMAARAGAVLADMEFVQFHPTALHCHNRPLALVSEAVRGEGAVLINERGERFMADIPGAELAARNIVAQAISAEITRGGQVFLDARQALGARFSTRFPTITALCHKVGIDPVHMPIPVCPAAHYHMGGIAIDHQGRSSIPGLWVAGEAASTGLHGANRLASNSLLEAVVMGTRAARDITFHNTPHPLGTIPITPKKPDTTLIRPIVSQCLGVLRHAADMHRAIAALLPFVEGEEESSDPAIVALLIAIFAYLRTESRGAHARTDFPLKHDTTQRRHMTLEDVLEIAHSCVAQRKEKIS
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase, LASPO, Quinolinate synthase B.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTHS_THEM4
Sequence: MKTDIEIAREAKLKRISDIAKDIGIEEKYLEPYGKYIAKVDLKFLKTLNNKKDGKLILVTAITPTPAGEGKTTTSIGLSMALNRLGKKSIVTLREPSLGPVFGIKGGAAGGGYSQVLPMENINLHFTGDIHAISSAHNLISAVIDSHIKFGNNLNINPTKVFWKRTMDMNDRALRQIIVGLGGNANGLPREDGFIITAASEIMAILCLAKDLKDLKERLGNIVVAESFDKKLVRVKDLKIEGALTALLKDAINPNIVQTIENTPAFIHGGPFANIAHGTNSIIATKLALKLTDYVVTEAGFAADLGAEKFLDFVTQVGNFDVNAVVLVATIKALKYHGGIKKDELNKENVDAMLKGMENLKTHIENLKLYNVPVVVALNVFASDTTNELKAFSEHCNAPHALVRAFEKGSKGTIELANTVLENISDSKHIPILNPEMSIEEKIETLATKVYRARKVIYTDTAKSKLKFLKRHGFETLPVIVAKTQSSISDDPKKLNAPRDYNFTIRDFELSAGAGFVVALAGEIMRMPGLSKIPNAVNIDVDEDGNIVGLS
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: APD73_APIME
Sequence: KNFALAILVVTFVVAVFGNTNLDPPTRPTRLRREAKPEAEPGNNRPVYIPQPRPPHPRLRREAEPEAEPGNNRPVYIPQPRPPHPRLRREAELEAEPGNNRPVYISQPRPPHPRLRREAEPEAEPGNNRPVYIPQPRPPHPRLRREAELEAEPGNNRPVYISQPRPPHPRLRREAEPEAEPGNNRPVYIPQPRPPHPRLRREAEPEAEPGNNRPVYIPQPRPPHPRLRREAEPEAEPGNNRPVYIPQPRPPHPRLRREAKPEAKPGNNRPVYIPQPRPPHPRI
What is the function of this protein?
Apidaecins have bactericidal activity; predominantly against Gram-negative bacteria (PubMed:2676519, PubMed:7929322).  They seem to interfere with cell propagation (PubMed:2676519).
What are the official names of this protein?
Apidaecins type 73.
What is the protein family that this protein belongs to?
Belongs to the apidaecin family.
What are the subcellular locations of this protein?
Secreted.
Protein: POL_HTL32
Sequence: MGKTYSSPINPIPKAPKGLAIHHWLNFLQAAYRLQPGPSEFDFHQLRKFLKLAIKTPVWLNPINYSVLAGLIPKNYPGRVHEIVAILIQETPAREAPPSAPLAEDPQKPPPYPEQAQEASQCLPILHPHGAPAAHRPWQMKDLQAIKQEVSSSAPGSPQFMQTIRLAVQQFDPTAKDLHDLLQYLCSSLVASLHHQQLETLIAQAETQGITGYNPLAGPLRIQANNPNQQGLRKEYQNLWLSAFSALPGNTKDPTWAAILQGPEEPFGSFVERLNVALDNGLPEGTPKDPILRSLAYSNANKECQKLLQARGQTNSPLGEMLRACQTWTPRDKNKILMVQPKKTPPPNQPCFRCGQVGHWSRDCKQPRPPPGPCPVCQDPTHWKRDCPQLKTDTRDSEDLLLDLPCEAPNVRERKNLLRGGGLASPRTILPLIPLSQQKQPTLHIQVSFSNTPPVSVQALLDTGADITVLPACLCPPDSNLQDTTVLGAGGPSTNKFKILPCPVHIHLPFRRQPVTLTACLIDINNQWTILGRDALQQCQSSLYLADQPSKVLPVLAPKLIGLEHLPPPPEVSQFPLNPERLQALTDLVSRALEAKHIEPYQGPGNNPIFPVKKPNGKWRFIHDLRATNSVTRDLASPSPGPPDLTSLPQGLPHLRTIDLTDAFFQIPLPTIFQPYFAFTLPQPNNYGPGTRYSWRVLPQGFKNSPTLFEQQLSHILTPVRKTFPNSLIIQYMDDILLASPAPGELAALTDKVTNALTKEGLPLSPEKTQATPGPIHFLGQVISQDCITYETLPSINVKSTWSLAELQSMLGELQWVSKGTPVLRSSLHQLYLALRGHRDPRDTIKLTSIQVQALRTIQKALTLNCRSRLVNQLPILALIMLRPTGTTAVLFQTKQKWPLVWLHTPHPATSLRPWGQLLANAVIILDKYSLQHYGQVCKSFHHNISNQALTYYLHTSDQSSVAILLQHSHRFHNLGAQPSGPWRSLLQMPQIFQNIDVLRPPFTISPVVINHAPCLFSDGSASKAAFIIWDRQVIHQQVLSLPSTCSAQAGELFGLLAGLQKSQPWVALNIFLDSKFLIGHLRRMALGAFPGPSTQCELHTQLLPLLQGKTVYVHHVRSHTLLQDPISRLNEATDALMLAPLLPLDPTTLHQLTHCNPYALRNHGATASEAHAIVQACHTCKVINPQGRLPQGYIRRGHAPNDIWQGDVTHLQYKRYKYCLLVWVDTYSGAVSVSCRRKETGSDCVASLLVAISILGKPQNINTDNGAAYLSQEFQQFCNSLAIKHSTHIPYNPTSSGLVERTNGILKTLISKYLLDNHHLPLETAVSKSLWTINHLNVLPSCQKTRWQLHQAQPLPPVPEDTLPPHTSPKWYYYKIPGLTNSRWSGPVQSLKEAAGAALIPVGGSYLWIPWRLLKRGICPRPESSAAVDPKTRDHQLHG
What is the function of this protein?
Integrase catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.  This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA.  The first step in the integration process is 3' processing.  This step requires a complex comprising the viral genome, matrix protein, and integrase.  This complex is called the pre-integration complex (PIC).  The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed dinucleotides OH's at the 3' ends.  In the second step, the PIC access cell chromosomes during cell division.  The third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5'-ends of strands of target cellular DNA at the site of integration.  The 5'-ends are produced by integrase-catalyzed staggered cuts, 5 bp apart.  A Y-shaped, gapped, recombination intermediate results, with the 5'-ends of the viral DNA strands and the 3' ends of target DNA strands remaining unjoined, flanking a gap of 5 bp.  The last step is viral DNA integration into host chromosome.  This involves host DNA repair synthesis in which the 5 bp gaps between the unjoined strands (see above) are filled in and then ligated (By similarity).
What are the official names of this protein?
Gag-Pro-Pol polyprotein, Pr160Gag-Pro-Pol.
What are the subcellular locations of this protein?
[Matrix protein p19]: Virion. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p15-pro]: Virion.