PharMolix/UniProtQA huggingface dataset:
Protein: ERIC1_HUMAN
Sequence: MAAHRKHVFVEKVLQRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCWPEPSSCGSPENASSGDDTEDQDPHDQPKRRRIRKHKSKKKFKNPNNVLIEQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNEKAHSILNFLKSTQEMYFYDGVSRDAASAALADAAEELLDRLASHSMLPSDVSILYHMKTLLLLQDTERLKHALEMFPEHCTMPPDHARVISAFFSYWITHILPEKSSD
What are the official names of this protein?
Glutamate-rich protein 1.
Protein: HIS6_BIFLO
Sequence: MSLAVRVIPCLDVDAGRVVKGVHFENLKDAGDPVELAAEYYRQRADEITFLDVTASSSHRNTMIDVVSRTAEQVFIPMTVGGGVRTPEDVDSLLRCGADKVGVNTAAINDPSLISRVADRFGNQVLVLSVDARREKGEQHTQSGFEVTTMGGRKSTGIDAIWWVKRAEQLGAGEILLNSMDADGTKEGFDLEMIRAVRKEVKIPIIASGGAGKVEDFPPAIEAGADAVLAASVFHYGILTIADVKAELKKHGYTVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_KLEP7
Sequence: MLRIADKTFESHLFTGTGKFAAPKVMVEAIRASGSQLVTLAMKRVDLRQRNDAILAPLLAAGVSLLPNTSGAKTAEEAVFAARLAREALGTHWLKLEIHPDARWLLPDPIETLKAAELLVREGFVVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLETKAMLEIIIEQATVPVVVDAGIGVPSHAAQALEMGADAVLVNTAIAVADDPVAMARAFRMAIDAGLLARQAGPGARSTQAQATSPLTGFLEALA
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPR_SALPB
Sequence: MTQHSPYSSAIAEQRNQEWLRFVELLRQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKTELGAGIATITRGSNSLKSAPVELRHWLENVLLKSA
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_ACIB3
Sequence: MQIFYDKDCDLSIIQSKKVAIIGYGSQGHAHALNLKDSGVDVTVGLRAGSASWKKAENAGLKVAEVPAAVKQADLVMILTPDEFQSQLYRDVIEPNIKEGATLAFAHGFSVLYNQVVPRKDLDVIMVAPKAPGHTVRSEFQRGSGVPDLIAIHQDASGNARNVALSYASGVGGGRTGIIETSFREETETDLFGEQAVLCGGAVELVKMGFETLVEAGYAPEMAYFECLHELKLIVDLMFEGGIADMNYSVSNNAEYGEYVTGPEVINEQSREAMRNALKRIQSGEYAKMFIQEGALNYPSMTARRRQNAAHGIEQTGAKLRAMMPWIQANKIVDKEKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RSGA_LEPIC
Sequence: MSQPNSILMSYGWDPSIYLEEPKLLEGLKPGRVLAVYGEYSKIIIEQGEKKGIFSGALMASGESIVTGDWVLIREIEGDELCIVEKILPRKTFLRRSNPGKRKGSQAIASNIDLLLVIMGLDNDYSPRRIERYLFLAKVSGAQVTIVLNKKDLCMDPENKFMEIKMIAGETPIEMISALDLKQTRTILQWIDPGKTIAFLGSSGAGKSTIINSLLGGEIQKTNEVKVSDGTGKHTTTRRELFLLPSGGVLMDNPGIREVGLFSEGSEDELEEVFPEIAVAAEECRFNDCSHNEEPNCGVVAAVKDGRISEARYFSYLKLSKELMAYQALNDPEEARKKKQKDKQMSKALQKRLKDKGRK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PECE_MASLA
Sequence: MTAACCAQPILSPEAAIAALAGEDNQIRYYAAWWLGKHQVQAGCAALCEALFDERYRIPSGGYPLRRQAARALGQLKNPQAVPALIAALACEEDLGLREAVIQALAMIGDRRAVHPLVQLLQSQQPQPYEALIEALATLQVWSARPQIEPFLYHSSERVQCAAARYLYLLTKQPQYLERIVQNLNHDNMYLRWAAIFDLAALGHRQAVDAILAAKVPNSLKLLNLKRILETLLDGDRSQLNNGEFCQNQSDRETIELLFQAIDDLLIQL
What is the function of this protein?
An enzyme involved in the biosynthesis of bilin.
What are the official names of this protein?
Bilin biosynthesis protein PecE.
What is the protein family that this protein belongs to?
Belongs to the CpcE/RpcE/PecE family.
Protein: BNCH_CAEEL
Sequence: MDVRFPPYIFSMPHLIYNSWLSLNAPKLAQLQLQSIKLVGQDKSINQSELPVNSENISIRVETETNIDSLAKEEKLSEHVHDEKADKIEKTSEDNDTSTLLKLKRRVACDICSKSFCDKGALKIHTSAVHLREMHTCTVTGCGKQFSSRRSRNRHSSNNNPKLHMPESLTLTGSGLSMKTSLDTFWPTRFLLGKDHPLDLSLNLV
What is the function of this protein?
Probable transcription factor (PubMed:28056346).  Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons (PubMed:28056346).  Required throughout development to repress transcription by unc-3, probably acting by binding to specific promoter elements (PubMed:28056346).  Represses expression of DA and DB motor neuron-specific effector genes, such as unc-129 and unc-53, in VA and VB motor neurons (PubMed:28056346).
What are the official names of this protein?
Basonuclin zinc finger protein homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y101_STAA3
Sequence: MIKRVNKLVLGISLLFLVISITAGCGMGKEAEIKKSFEKTLSMYPIKNLEDLYDKEGYRDDQFDKNDKGTWIVNSQMAIQNKGEALKIKGMLLKIDRNTRSAKGFYYTNEIKTEKYEVAQDNQKKYPVKMINNKFISTEEVKEENIKKEIENFKFFAQYSNFKDLMNYKDGDISYNPEVPSYSAQYQLTNDDYNVKQLRKRYDIPTNKAPKLLLKGTGNLKGSSVGYKKIEFTFLENKNENIYFTDSLHLEPSEDK
What are the official names of this protein?
Uncharacterized lipoprotein SAUSA300_0101.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RECA_STUST
Sequence: MDENKKRALAAALGQIEKQFGKGAVMRMGDHDRQAIPSISTGSLGLDIALGIGGLPKGRIVEIYGPESSGKTTLTLSVIAAAQRMGSTCAFVDAEHALDPDYAGKLGVNVDDLLVSQPDTGEQALEITDMLVRSNAVDVIIVDSVAALVPKAEIEGEMGDAHVGLQARLMSQALRKITGNIKNANCLVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRTGAVKEGDEVVGSETRVKVVKNKVAPPFRQAEFQILYDQAFYRNGEIIDLGVQQGLVEKSGAWYAYKGSKIGQGKANAAKYLEENPEIGQEIEQQIRAKLLVTSANTKATPVAEDLADADI
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
Protein: PURL_BRUAB
Sequence: MTISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTSGPRVIQGPGENAGVVDIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNAFGVPTVGGEVNFDKRYNGNILVNAFAAGLARHDGIFLSEAEGVGLPVVYLGAKTSRDGVGGATMASAEFDESIEEKRPTVQVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVREENMTAYEMMLSESQERMLMVLKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGEEVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVEDYSAALLKLIGSPDLSSRRWVYEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECWRNITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNETNGQAILPTPTIAGVGLLPDWSQMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADGPAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIAVAEMAIKSGKGATLDAGDGLPHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADLTQAYEGWFPNFMNGELTGNN
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATMA_SALT1
Sequence: MLKIITRQLFARLNRHLPYRLVHRDPLPGAQTAVNATIPPSLSERCLKVAAMEQETLWRVFDTHPEGLNAAEVTRAREKHGENRLPAQKPSPWWVHLWVCYRNPFNILLTILGGISYATEDLFAAGVIALMVGISTLLNFVQEARSTKAADALKAMVSNTATVLRVINENGENAWLELPIDQLVPGDIIKLAAGDMIPADLRIIQARDLFVAQASLTGESLPVEKVAATREPRQNNPLECDTLCFMGTNVVSGTAQAVVMATGAGTWFGQLAGRVSEQDNEQNAFQKGISRVSMLLIRFMLVMAPVVLIINGYTKGDWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKHLDAIQNFGAMDILCTDKTGTLTQDKIVLENHTDISGKPSEHVLHCAWLNSHYQTGLKNLLDTAVLEGVDETAARQLSGRWQKIDEIPFDFERRRMSVVVAEDSNVHQLVCKGALQEILNVCTQVRHNGDIVPLDDNMLRRVKRVTDTLNRQGLRVVAVATKYLPAREGDYQRIDESDLILEGYIAFLDPPKETTAPALKALKASGITVKILTGDSELVAAKVCHEVGLDAGDVIIGSDIEGLSDDALAALAARTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFSNMLKYIKMTASSNFGNVFSVLVASAFLPFLPMLPLHLLIQNLLYDVSQVAIPFDNVDEEQIQKPQRWNPADLGRFMVFFGPISSIFDILTFCLMWWVFHANTPETQTLFQSGWFVVGLLSQTLIVHMIRTRRLPFIQSRAAWPLMAMTLLVMVVGVSLPFSPLASYLQLQALPLSYFPWLIAILVGYMTLTQLVKGFYSRRYGWQ
What is the function of this protein?
Mediates magnesium influx to the cytosol.
What are the official names of this protein?
Magnesium-transporting ATPase, P-type 1, Mg(2+) transport ATPase, P-type 1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YBEY_ALISL
Sequence: MSIELDLQIACENEKDLPSEKDFMSWLNAVLPQFQPQAELTIRIVDEKESHELNHQYRGMDKPTNVLSFPFEAPPEVEIDLLGDLIICRQVVEKEAVEQNKPLLAHWAHMVVHGSLHLLGYDHIEDEEAEEMESLETELMQEMGFEDPYLAEK
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XGEA_EMENI
Sequence: MKLLALSLASLASAATITRRADFCGQWDTATAGNFIVYNNLWGQDNADSGSQCTGVDSANGNSVSWHTTWSWSGGSSSVKSYANAAYQFTATQLSSLSSIPSTWEWQYSTTDVVANVAYDLFTSSSIGGDSEYEIMIWLAALGGAGPISSTGSSIATVTLGGVTWNLYSGPNGSMQVYSFVASSTTESFSADLMDFINYLVENQGLSNSQYLTHVQAGTEPFTGSDATLTVSSYSVSVS
What is the function of this protein?
Catalyzes endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan with retention of the beta-configuration of the glycosyl residues.  Specific for xyloglucan and does not hydrolyze other cell wall components.  Active against tamarind xyloglucan.
What are the official names of this protein?
Xyloglucan-specific endo-beta-1,4-glucanase A, Xyloglucanase A, Xyloglucanendohydrolase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 12 (cellulase H) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMKL_IDILO
Sequence: MYRFFIACSKGLEGLLFDELQEFNLSHVKQTLAGCYIEADLQQAYTVAMWSRLASRMLLQLGEKEVSSLDEIKLALTQFSWSKVFDANRTFVVDFSGGNDDIRHTQFGAQLVKDCIVDNFRNSGFERPSIDKQDPDIRIAVRVHKDKLTWSLDFTGDGMHKRGYRLQQGEAPLRETLAAAILVRAGIKNELEKDEPVIFDPFCGSGTLVIEAAMMAMDHAPGLSRAHWGFLFWHEHSPQLWHDVLEQAEQRFKEGKKNFKGHLKGSDNNPHLVAKAKDNAKRVLLHEVIEFEVADATNCEAPAESGLLVCNPPYGERLGEAVETLLLYRRFGRQLKDTFQNWHIAVLAGDEQLLKRLKLRSHKKYPLLNGAIPVNLALYDLTKEQPDFAESQADDLVNRVKKNHAKLSKWANKEGLDCWRVYDADIPEYNAAIDIYQDYVVVQEYAAPKDIPEGVANDRLWFMLESLSSALPVSEDKIILKRRQRQSGKQQYERQSQDSTVLTVNEYGAKFEVNLTDYLDTGLFMDHRLVRKELLDKCEELDVLNLFAYTCTASVQAARAGAARVVSVDMSKTYLKWGERNFALNRLRGDYQFIQADCFIWMREQRGKQLFDVIFLDPPTFSNSKRMSGTLDIQRDHVGLIKTATGMLKEDGVILFSNNRKKFRIDTEGLDKAGLEVNDQTQASIPEDFKRHKGIHHYYIISRA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRG6_CAEEL
Sequence: MANSTSFLGCSRFYATFEENLKLMGQLVYLIPSFILISKMIYVIQVKHRGDYHEQRRFWLLYTMDLALSLLNLFFDIFYYRLTLFVPQICESFSFFLRANPLLIDITYPLWFYFHVGKMVAQMSISFERMTFNLLKPNDYRRIWKHGLTACVIMIIFVPFSIIWNILISDKYIQFYFGGFQPNYSRRVNWFGTTAWQLTYMQISMAVTLLSNIVTGAILWKSQNQSRKSRLLCRIWFAISTEYLLSACAFCYLHMKTFAFDYSNLIFMLVIFVWDGFNILSPVIMISMNKSLRKQVFAMSGGSEDLEISVA
What are the official names of this protein?
Serpentine receptor class gamma-6, Protein srg-6.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein srg family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y163_ARCFU
Sequence: MNISPSPLTDTGKALLRLNLIAIALLWLYPLLTYSQLPETVPTHFGAGGEPDRFGSREELLILPAVFSIAPAIILIITKLRFTLINRYPQFINLPAFYMNIGKIREERRSYWVNRYFEPVLLLSLILSAGFLGMEYAIFHATLSGELPLLFYIILIFVIAAPLFIFFLYLSMISAQMSREIGE
What are the official names of this protein?
Uncharacterized protein AF_0163.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: WN10B_MOUSE
Sequence: MLEEPRSRPPPLGLAGLLFLALFSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLGLCLRSPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKTFPISQPSPVPGSVPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAIGAALRERLSRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTLGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
What is the function of this protein?
Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade.  Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs.  Involved in signaling networks controlling stemness, pluripotency and cell fate decisions.  Acts in the immune system, mammary gland, adipose tissue, bone and skin.
What are the official names of this protein?
Protein Wnt-10b, Protein Wnt-12.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: RS11_DESAP
Sequence: MARRPRAKKKERKNIETGVAHIKSTFNNTVITISDVRGNAISWSSAGTVGFKGSRKSTPFAAQLAAEKAAREAMEHGMREVAVMVKGPGAGREAAIRSLQAAGLEVSLIKDVTPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: NEIL2_BOVIN
Sequence: MPEGPSVRKFHHLVSPFVGQQVVKTGGSSKKLNPTSFQSLWLQDSQVHGKKLFLRFDPDEEAVSLGNSLLSEPLREGEQKDKARHHQEASDPSSWSPGGDSAVPSGDDGLQCLGGDTPAGGAERWLQVSFGLFGSIRVNEFSRAKKANKRGDWRDPVPRLVLHFSGSGFLAFYNCQMTWRFSSPVVSPASDILSEKFHRGQALEALGREQPICYTLLDQRYFSGLGNIIKNEALFRAGIHPLSPGSLLGLPRLEALVDHVVAFSADWLQGKFQGTRQHTQIYQKEQCPAGHQVVRESLGPPGGFQRLTWWCPQCQPRLSADEPKQLQPS
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles).  Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
What are the official names of this protein?
Endonuclease 8-like 2, DNA glycosylase/AP lyase Neil2, DNA-(apurinic or apyrimidinic site) lyase Neil2, Endonuclease VIII-like 2, Nei homolog 2, NEH2, Nei-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNAA_BACCZ
Sequence: MENISDLWNSALKELEKKVSKPSYETWLKSTTAHNLKKDVLTITAPNEFARDWLESHYSELISETLYDLTGAKLAIRFIIPQSQAEEEIDLPPAKPNAAQDDSNHLPQSMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVIEHNPNAKVVYLSSEKFTNEFINSIRDNKAVDFRNKYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNALHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAEALKDIIPNSKPKIISIYDIQKAVGDVYQVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLKTDTQLQKQVEEINDILK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROX_ECOLI
Sequence: MRHSVLFATAFATLISTQTFAADLPGKGITVNPVQSTITEETFQTLLVSRALEKLGYTVNKPSEVDYNVGYTSLASGDATFTAVNWTPLHDNMYEAAGGDKKFYREGVFVNGAAQGYLIDKKTADQYKITNIAQLKDPKIAKLFDTNGDGKADLTGCNPGWGCEGAINHQLAAYELTNTVTHNQGNYAAMMADTISRYKEGKPVFYYTWTPYWVSNELKPGKDVVWLQVPFSALPGDKNADTKLPNGANYGFPVSTMHIVANKAWAEKNPAAAKLFAIMQLPVADINAQNAIMHDGKASEGDIQGHVDGWIKAHQQQFDGWVNEALAAQK
What is the function of this protein?
Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake.  Binds glycine betaine and proline betaine with high affinity.
What are the official names of this protein?
Glycine betaine/proline betaine-binding periplasmic protein, GBBP.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL17_HELPG
Sequence: MRHKHGYRKLGRTSSHRKALLKNLAIALIEHNKIETGIYKAKELRSYIEKLTTTARVGDFNAHRHVFAYLQNKEATHKLVTEIAPKYAQRNGGYTRIQRTTFRRGDASTLATIEFV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: STHA_AZOVI
Sequence: MAVYNYDVVVIGTGPAGEGAAMNAVKAGRKVAVVDDRPQVGGNCTHLGTIPSKALRHSVRQIMQYNNNPLFRQIGEPRWFSFADVLKSAEQVIAKQVSSRTGYYARNRIDTFFGTASFCDEHTIEVVHLNGMVETLVAKQFVIATGSRPYRPADVDFTHPRIYDSDTILSLGHTPRRLIIYGAGVIGCEYASIFSGLGVLVDLIDNRDQLLSFLDDEISDSLSYHLRNNNVLIRHNEEYERVEGLDNGVILHLKSGKKIKADAFLWSNGRTGNTDKLGLENIGLKANGRGQIQVDEHYRTEVSNIYAAGDVIGWPSLASAAYDQGRSAAGSITENDSWRFVDDVPTGIYTIPEISSVGKTERELTQAKVPYEVGKAFFKGMARAQIAVEKAGMLKILFHRETLEILGVHCFGYQASEIVHIGQAIMNQKGEANTLKYFINTTFNYPTMAEAYRVAAYDGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISX_OCEIH
Sequence: MEILSLHQWKQQQDTKSSTIRNKQVDQDVLRIIEQVQIQGDEALKHYTLQFDQVNLNSFEVTSNEWEQAIKKVDSTLLDALETAAGNIQRYQSEMLESNWSITPETGVKLGQQVNPLDRVGIYIPGGKASYPSTVLMDAIPAKVAGVKEIIITSPPNKNGEIDPVVLAAAKIAGVTKVYKVGGAQAIAALTYGTETIPSVDKIVGPGNIYVTRAKKWVFGDIAIDMIAGPSEICIFADSSAPVPYVAADLLSQAEHDEEASSLCITTDRSFAKLLQEEVNRQIPLLERKEIIEASISQNGKIIICDNNEEAINTINQLAPEHLQLMTIDSEQLCPKIKHAGAIFIGNYSSEPLGDYFAGPSHTLPTNGTAKFSSPLGVYDFVKKTSLIQYSKNKLAEAADTIITLAEAEGLTAHANAIRIRKENDNA
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: YOL6_CAEEL
Sequence: MILLAFLMFIPGVETKESPVKCEYSDEKKVSECLQVFLYFKTRQCLTMKKLQPMLDYATKLQAETGAMQFPLQGGQVFNQLCSIYTDFKVEAQKEYISCKIAATQAISEAQGAKGSSTEAYLTEMCRAMDGYLRCSHPIILAKCGSDAWTLVSTVCLSRAKLFF
What are the official names of this protein?
Uncharacterized protein ZK370.6.
Protein: ARL14_HUMAN
Sequence: MGSLGSKNPQTKQAQVLLLGLDSAGKSTLLYKLKLAKDITTIPTIGFNVEMIELERNLSLTVWDVGGQEKMRTVWGCYCENTDGLVYVVDSTDKQRLEESQRQFEHILKNEHIKNVPVVLLANKQDMPGALTAEDITRMFKVKKLCSDRNWYVQPCCALTGEGLAQGFRKLTGFVKSHMKSRGDTLAFFKQN
What is the function of this protein?
GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.
What are the official names of this protein?
ADP-ribosylation factor-like protein 14, ADP-ribosylation factor 7.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle. Note=Colocalizes with MHC II-containing cytoplasmic vesicles.
Protein: TRA6_ENTFA
Sequence: MTQVHFTLKSEEIQSIIEYSVKDDVSKNILTTVFNQLMENQRTEYIQAKEYERTENRQSQRNGYYERSFTTRVGTLELKVPRTRDGHFSPTVFERYQRNEKALMASMLEMYVSGVSTRKVSKIVEELCGKSVSKSFVSSLTEQLEPMVNEWQNRLLSEKNYPYLMTDVLYIKVREENRVLSKSCHIAIGITKDGDREIIGFMIQSGESEETWTTFFEYLKERGLQGTELVISDAHKGLVSAIRKSFTNVSWQRCQVHFLRNIFTTIPKKNSKSFREAVKGIFKFTDINLAREAKNRLIHDYIDQPKYSKACASLDDGFEDAFQYTVQGNSHNRLKSTNLIERLNQEVRRREKIIRIFPNQTSANRLIGAVLMDLHDEWIYSSRKYINFDK
What is the function of this protein?
Required for the transposition of the insertion element.
What are the official names of this protein?
Transposase for insertion sequence element IS256 in transposon Tn4001.
What is the protein family that this protein belongs to?
Belongs to the transposase mutator family.