PharMolix/UniProtQA huggingface dataset:
Protein: MMM1_PENRW
Sequence: MALQQHEPAPFAPQSSLSFTQGFLLGQLSVVLLIGAFIKFFIFGEAPPPPSRGMSNRTTHRRYSSVYSPPQDSQKSLREKPSTSNVLRPVPSTSTNTRSILRKTYYSAIPTNPTSKHGRHRMHHSSHQPESLDWFNVLIAQTIAQYRETAYSLKDSPTSSILSSLTAAMNNPEKKPSFIDKIKVTDISLGEEFPIFSNCRIIAVDDPVSDGGRLQALLDVDLSDDNLSIAVETSMLLNYPKPRSAIIPIALSVSVVRFSGTLCISLIPASTEPPEPLQTPAGSPAPPTSDPRDNAGNRPPGPGEHTASQDELPPKSSPKSNVAFSFLPDYRLDLSVRSLIGSRSRLQDVPKIAQLVEARVHAWFEERVVEPRVQVVGLPDLWPRMGRTGVRPGEDSDAGSTAPPRSAGSTESSGPPRFSDDHGREPEGLRFRGALDSRLGLGAGSRTNSFNVDMGGLRSSSMTRQQSGGARSDHFEMPGAMPAGTPVGTPGIPDN
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Maintenance of mitochondrial morphology protein 1.
What is the protein family that this protein belongs to?
Belongs to the MMM1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: DNM3B_HUMAN
Sequence: MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
What is the function of this protein?
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development.  DNA methylation is coordinated with methylation of histones.  May preferentially methylates nucleosomal DNA within the nucleosome core region.  May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation.  Seems to be involved in gene silencing (By similarity).  In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.  Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs.  Functions as a transcriptional corepressor by associating with ZHX1.  Required for DUX4 silencing in somatic cells (PubMed:27153398).
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURD_ALBFT
Sequence: MNALQDQHVLILGLGASGLAMARWCARCGARVTVADTRSAPPQLAALQRELPAAQFISGAFDAALVVGTDVRAVFKSPGLSPLDVATVIEAANTIGIRATGELGLFSQALADLKATQNYTPKVLAVTGTNGKTTVTALTGLLVERGGKSVAVAGNIGPTLLDTLIQHLAAGTLPEVWVIELSSFQLEGETGFEPSAAAVLNITQDHLDWHGSMAAYVAAKAHVFGATGLMILNREDPQVMAMLPEPVRVKLQRPQLRAHVTFGADLPRRPGDFGLEQVNGMLWLVRALEADETLKNRKGETPELFLQRLMPADALRIRGRHNAVNALAALALAQAAGCALGPMLYGLRDYRGEPHRVAPIGIFNEVEFFDDSKGTNVGATVAALAGLGSERKVIVILGGEGKGQDFAPLVDPVSRYARAVVLIGRDAPLLRAALQATHVPLLEAESMAQAVALANAQAHAGDAVLLSPACASFDMFDNYEHRAQVFAQAVGELASAAGAAWEGAAP
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHLB_PSEAB
Sequence: MVEPQEGKTRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPHKGERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLLYNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELLGRKITCEMPPAELLKPVPRKH
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIAS_POPTR
Sequence: MQSRFTFLATRTLKSTTTKAKNRTFSSSTVESSTKQPPQFSQTLAGLRARLAVESPTLSDFIHLQSNNTYSVEVGTKKKPLPKPKWMREAIPGGEKYVQIKKKLRELKLHTVCEEAKCPNLGECWSGGETGTATATIMILGDTCTRGCRFCNVKTSRTPPPPDPNEPTNVAEAIASWGLDYVVITSVDRDDLADQGSGHFAETVHKLKTLKPNMLIEALVPDFRGDRGCVEKVAKSGLDVFAHNIETVEELQSSVRDHRANFKQSLDVLMMAKEYAPPGTLTKTSIMLGCGEAPEQVVKTMEKVRAAGVDVMTFGQYMRPSKRHMPVSEYITPDAFEKYKTLGMEMGFRYVASGPMVRSSYKAGEFYIKSMIESDRSVSSQLPIS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MNMA_STAAM
Sequence: MSNKDIRVVVGMSGGVDSSVTAHVLKEQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIEVCNQIGIPYYAVNFEKEYWDKVFTYFLDEYKKGRTPNPDVMCNKEIKFKAFLDHAMNLGADYVATGHYARIHRHEDGHVEMLRGVDNNKDQTYFLNQLSQQQLSKVMFPIGDIEKSEVRRIAEEQGLVTAKKKDSTGICFIGEKNFKTFLSQYLPAQPGDMITLDGKKMGKHSGLMYYTIGQRHGLGIGGDGDPWFVVGKNLKDNVLYVEQGFHHDALYSDYLIASDYSFVNPEDNDLDQGFECTAKFRYRQKDTKVFVKRENDHALRVTFAEPVRAITPGQAVVFYQGDVCLGGATIDDVFKNEGQLNFVV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_SINFN
Sequence: MSELETLERTLLADIDAAADEGAIEALRVGALGKKGSISELLKTLGTMSPEERQTRGARINALKNIVTEAISARKLALKDAAIAERLARETVDISLPVRSSPAERGRIHPISQIVDEITAIFGDMGFSIAEGPDIETDYYNFTALNFPEGHPAREMHDTFFFQPDENGERKVLRTHTSPVQIRTMEAEKPPIRIIIPGKTYRQDSDATHSPMFHQVEGLVIDKTANVANMRWVLEEFCKAFFEVDQVTMRFRPSFFPFTEPSFEVDIQCDRSGPIVKFGEGKDWMEILGCGMVHPNVLRAGGLDPDEYQGFAWGMGLDRIAMLKYGMPDLRDFFNADVRWMTHYGFRPLDMPTLFGGLSA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_BPSP
Sequence: MAKLNQVTLSKIGKNGDQTLTLTPRGVNPTNGVASLSEAGAVPALEKRVTVSVAQPSRNRKNFKVQIKLQNPTACTRDACDPSVTRSAFADVTLSFTSYSTDEERALIRTELAALLADPLIVDAIDNLNPAY
What is the function of this protein?
Acts as a translational repressor of viral replicase synthesis late in infection.  This latter function is the result of capsid protein interaction with an RNA hairpin which contains the replicase ribosome-binding site.
What are the official names of this protein?
Capsid protein, CP, Coat protein.
What are the subcellular locations of this protein?
Virion. Note=The shell is composed of 89 dimers of the capsid protein and 1 copy of the maturation protein.
Protein: PLH28_FORAG
Sequence: MKYNKLLFSLLLLAVFCFSCKEEQKLQTSLDFDKVLLNAKSNPIAIESESPLFSWIIKAEGFGKSQSAYHILVASSLDKLDETHADVWNSNKVESSKSTFVKYEGKELKAATRYYWKVKVWDKSNQESNWSEPQYFQMGLLDESNWGEAKWITLTNDTRTSEYRFREYKTGRMEQPIQVDGFAASYFRNKINLNKEVDNAQVYICGLGYYEFFLNGEKVGDHVLDPAPSNYDKQAYYVNYDITEQLNSGENALGIILGNGFYGQNISWKNDPESDRDLAYGPPTVRVLLKLKYKDGTESEFFSDETWKESTGPIVFNNIYGGDTYDARFELGDWTSTNYDDSSWGFAKETAPEIKNISAQQIPAIKKLQDYEPQNVFKGSDGEWIVDFGQNIAGWVKLNVSEKEGQLIEVITTEALLTNGRDIFPGSTGGGANGMAQIYQYICKGDGQESWEPKFSYHGFRYAKIKGVSTKPDADMIKAVLVATDIQETGSFECSDDLFNKMHNISKWTIVDNVHGIPEDCPHREKCGWLGDAHAFCEYALYNYDMYDFYKKYMEDIRTQMLPTKGHNNPELKFQVPTMIAPGKRTSSYAKIDWGVATMYLPWYNYLYYGDDAIVNEYYPEMKDLTNFYLNFKGENGIMQDGMGDWCPPRWDRRTNPEAMECDPIISANAYFYDVLGIMETFAKMNNDGAFQSEMKAEKEALKDAFNKAFLVEIPNTDFKWYQSQTATVQALQFGMVPEEEIENVVNGLEYDIVEVKGGHHSTGIHGNRYIYTVLSKYGKADLAYRILTTPDFPSQTYIMNSGFTTWPERQFEWETMEGPTNSLNHPMHSGFSAYFFESLGGIKSSTKEAGYKQFIVNPEFPSQITQTKVSVPTPYGDIKNDWSFEEGKLSMTLEIPFNTEANLVLNQAELESLIINGKTFQNLQKNTKSVTLQGSNVILGSGKYKILYNKR
What is the function of this protein?
Alpha-L-rhamnosidase that may be involved in ulvan degradation (Probable).  Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall.  It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl) (Probable).
What are the official names of this protein?
Alpha-L-rhamnosidase, Glycosyl hydrolase 78 family protein P28, P28_GH78, Polysaccharide utilization locus H protein P28, PUL H protein P28.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 78 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Periplasmic side.
Protein: HUTC_PSEPU
Sequence: MPTPPVSALVAQMGEGPAPLYARVKQMIIQQIDNGSWPPHHRVPSESELVNELGFSRMTINRALRELTADGLLVRMQGVGTFVAEPKGRSALFEVNNIADEIAARGHQHSCQVITLTEEAAGSERALALDMREGQRVFHSLIVHFENGVPVQIEDRYVNAAIAPDYLKQDFTRQTPYAYLSQVAPLTEGEHVVEAILAEPEECRLLQIERGEPCLLIRRRTWSGRQPVTAARLIHPGSRHRLEGRFSK
What is the function of this protein?
Repressor which binds to the hutP region in the histidine utilization (hut) operon.  It blocks the expression of all the hut genes in the absence of inducer.
What are the official names of this protein?
Histidine utilization repressor.
Protein: A28_YMTV5
Sequence: MNPTSIVLIVIATVAVCLIIMQIYYIYENYDNIKEFNSTHSTLEYSKTINVFSLDRRIYDPNDHIYDVKQKWRCVNYKNNYVSVSVFGFKSNKDKNIKMFTTINDCINYTFSKSTHSDIYNPCILDDGFQNQDCIFLKSVI
What is the function of this protein?
Envelope protein required for virus entry into host cell and for cell-cell fusion (syncytium formation).
What are the official names of this protein?
Envelope protein A28 homolog, Protein 118.
What is the protein family that this protein belongs to?
Belongs to the poxviridae A28 protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Note=Component of the intracellular mature virion (IMV) membrane.
Protein: CDNE_RHOMG
Sequence: MPVPESQLERWSHQGATTTAKKTHESIRAALDRYKWPKGKPEVYLQGSYKNSTNIRGDSDVDVVVQLNSVFMNNLTAEQKRRFGFVKSDYTWNDFYSDVERALTDYYGASKVRRGRKTLKVETTYLPADVVVCIQYRKYPPNRKSEDDYIEGMTFYVPSEDRWVVNYPKLHYENGAAKNQQTNEWYKPTIRMFKNARTYLIEQGAPQDLAPSYFLECLLYNVPDSKFGGTFKDTFCSVINWLKRADLSKFRCQNGQDDLFGEFPEQWSEEKARRFLRYMDDLWTGWGQ
What is the function of this protein?
Cyclic dinucleotide synthase that catalyzes the synthesis of 3'3'-cyclic UMP-AMP (cUMP-AMP) from UTP and ATP, a second messenger for cell signal transduction.
What are the official names of this protein?
Cyclic UMP-AMP synthase, cUMP-AMP synthase, 3',3'-cUAMP synthase, cGAS/DncV-like nucleotidyltransferase, CD-NTase.
What is the protein family that this protein belongs to?
Belongs to the CD-NTase family. E01 subfamily.
Protein: IPO13_BOVIN
Sequence: MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQASPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKSLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQDQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHFPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSISSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGSELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVEPVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSVWIKEALQAPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY
What is the function of this protein?
Functions in nuclear protein import as nuclear transport receptor.  Serves as receptor for nuclear localization signals (NLS) in cargo substrates.  Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).  Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family.  Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity).
What are the official names of this protein?
Importin-13, Imp13.
What is the protein family that this protein belongs to?
Belongs to the importin beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL2_WOLPP
Sequence: MGMKFFNPVTPSSRGTILISKIGLSKDKPEKSLVFGKKSSGGRNNHGRITTRHRGGGHKKKYRVIDFKRNRSDQGIVEKIEYDPNRSGFLALISYKEDDTKSYILAPQGMKPGDVVTAGDDADILPGNCLLLKHIPVGSFVHNVELKPGNGAAIARAAGCYAQIVGRDGQYVLLRLRSGQIRLILSSCKATIGVVSNLDHKNRKLGKAGRSRWLGIRPAVRGVAMNPVDHPHGGGEGKTSGGRHPVTPWGVATKGKKTRKKNKSSDKYIKKLKG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: IF5A1_RAT
Sequence: MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK
What is the function of this protein?
mRNA-binding protein involved in translation elongation.  Has an important function at the level of mRNA turnover, probably acting downstream of decapping.  Critical for the efficient synthesis of peptide bonds between consecutive proline residues.  Can resolve ribosomal stalling caused by consecutive prolines during translation.  Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity.  With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis.  Regulates also TNF-alpha-mediated apoptosis.  Mediates effects of polyamines on neuronal process extension and survival (By similarity).  May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (PubMed:18606156, PubMed:19006180).
What are the official names of this protein?
Eukaryotic translation initiation factor 5A-1, eIF-5A-1, eIF-5A1, Eukaryotic initiation factor 5A isoform 1, eIF-5A, eIF-4D.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. Nuclear export of hypusinated protein is mediated by XPO4.
Protein: IXTPA_ARCFU
Sequence: MYFITSNEGKFREVREMASKYGIEIEWLKMEYIEPQGSSLEEIARLSAEMLAEKVEGEFVIEDSGLFVEALKGFPGPYSSYVFKTIGNEGILKLMEGVENRKAYFMAVVAYFDGKEVRTFTGKVEGEISREMRGTQGFGYDPIFLYGNKTFAEMATEEKNQVSHRRKAFEEFFRWLKENKI
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP.  Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.  Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: NAHQ_PSEAI
Sequence: MIKRTICLVYPLFCLASPTWAEESPWTYRIGMTNVAFDASAKVYLNGQRVPGGSADASDNNALTFDFGYAINDQWNVRAIVGIPPTTKVTGAGTLPGIQLGKITYAPTVLTLNYNLPALGPVRPHIGAGVNYTRIFESRDANLKSFDADHAWSPALHVGADIDVNRGWFVSIDIRKLYLKTDASGYLGPQEAKARVTLDPLLTSIAIGRQF
What is the function of this protein?
May be involved in the conversion of 2-hydroxy-4-(2'-oxo-3,5-cyclohexadienyl)-buta-2,4-dienoate to cis-O-hydroxybenzylidenepyruvate.
What are the official names of this protein?
Dibenzothiophene metabolism operon protein PahQ.
Protein: GCH1L_LISIN
Sequence: MKVANGYEYTAIMEKIAPKKLAMEGDPIGLQVGDLSKKVRKVMFTLDVLEEVVDEAIEKRVDLIIAHHPFLYRPTQHIDTTTKQGKMIKKLIKHDITVFAAHTNLDIAQGGVNDILADLLHLQDTTMIEETYTEPYCKIAVYVPENELESVRLALVNNGAGQIGTNYTECTFHTTGIGSFKPGTDANPTIGEKETLTSIPEVKIEAIFPQYLTETITKAVKIAHPYEEPAIDVYTLETQTYKEGLGRVGTLPKKISMVSFIDKLKTAFAIDNVRFVGDLKANVQKVAIIGGDGNKFIHQAKATGADVFITGDVYYHTAHDLLAINLPTIDAGHNIEKVMKGYLKNKMEEQAKILDYEAEFIVSEVNTDPFQFC
What are the official names of this protein?
GTP cyclohydrolase 1 type 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
Protein: Y488_MYCTU
Sequence: MMTLKVAIGPQNAFVLRQGIRREYVLVIVALCGIADGALIAAGVGGFAALIHAHPNMTLVARFGGAAFLIGYALLAARNAWRPSGLVPSESGPAALIGVVQMCLVVTFLNPHVYLDTVVLIGALANEESDLRWFFGAGAWAASVVWFAVLGFSAGRLQPFFATPAAWRILDALVAVTMIGVAVVVLVTSPSVPTANVALII
What are the official names of this protein?
Putative amino-acid transporter Rv0488.
What is the protein family that this protein belongs to?
Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS13_SHEVD
Sequence: MARIAGINIPDQKHTVIALTGIFGIGRTRARAICAATSIAEDAKIKELSEAQIDILREAVAEYTVEGDLRREVSMNIKRLMDLGCYRGIRHRRSLPLRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: ERA_COXB1
Sequence: MKPTYCGYAAIIGRPNVGKSTLLNQLLGQKISITSRKPQTTRYQILGVKTFKDIQVIYVDTPGLHAGTERTINRYMNRTARGALRDVDAIVFVIEPHWESQDAWVLDNLKEIETPVFLVINKVDKIKNRAELLPLIEKVSSLYAFQKIIPLSAKTGDQVGTLEQAVHQLMPESPFYFPPEQVTDRSDQFMASEIIREKLMRLLGQEIPYSLAVTLIEFRKEEKIIRISAVIWVEKKSQKGIVIGKGGERLKRVGTNARLDMEKWFGKKVFLQLWVKVKSGWADNERLLRELGFEE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: MOEA_STAAS
Sequence: MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETTTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQKDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFVDGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
What is the function of this protein?
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
What are the official names of this protein?
Molybdopterin molybdenumtransferase, MPT Mo-transferase.
What is the protein family that this protein belongs to?
Belongs to the MoeA family.
Protein: CO8G_MOUSE
Sequence: MLSPGAVLFFTLLLTASSLGQRTRKPIGSTSPISTIQAQVNFSAQKFAGTWLLVAVGSSCRFLQEQGHRAEATTLHAAPQGAAMAVSTFRKLDGICWQVRQLFENTGVPGRFLFQVSRARGPVHMVVAETDYQSFAILYLEQGRKLSVKLYVRSLPVNDSVLDVFERRVREANLTEDQILFFPKYGFCETADQLHILNEVPR
What is the function of this protein?
C8 is a constituent of the membrane attack complex.  C8 binds to the C5B-7 complex, forming the C5B-8 complex.  C5-B8 binds C9 and acts as a catalyst in the polymerization of C9.  The gamma subunit seems to be able to bind retinol (By similarity).
What are the official names of this protein?
Complement component C8 gamma chain.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.