PharMolix/UniProtQA huggingface dataset:
Protein: HEM1_LIMRJ
Sequence: MYLMCVSLNYHQLPLDLREKFSFTKEEVPKADKLLNDEKSILENLLISTCNRTEVYAVVDQIHTGRYYIRRFLAEWFHYTIDDFTKFVTVTTKDAVAEHLFKVITGLDSLIKGEPQILGQMKDAFQIATKEGTTGAILNHLFRQAITFSKRMHTKYRVSELAQSSGQAGLHQIKMQFGSLEGKTLAVVGLGQIGKHTAYNASNMGFSKVLLLNRTDSKAEQIATELQGVVEARPFNQLATVVHNVDAAIFAATVKQPLFKADEQISTMIVDLGVPRNVAVNSTKLKYYDVDHVHMILNSNDEKRRLMIQKIANEIPQEVNDFYIWEKQLHIVPVIRGLREHSLRIEGEAYDSLLRKLPELDSHERKVISKHMKSIVNQMIKGPIKEIKELSVTPGATADIDFFCKIFGMDNLKVENQNNDK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: MCP10_MAGSA
Sequence: METTLGSYARTLSLGMLVPSAICLLAGTFGLLGGSSIALWVVIAVSLLGVVGGVKIGGSARRMAGDLSTAIHVLSRSASGDLNARILDVRGSGGIGALQHSINRLLDLAEAFGKEAFAAVESANHGRYYRRIITTGLRGDFVLYAKTINQALKRMEARDAEFIAFANNQVKPVVNAVAAAATELEASSGAMSAQSTDTSHQAMTVAAAAEQASVNVQAVASAVEEFSASIKEISTQVHRAAAVASEAAGVASRTDTTVHGLSDAAQRIGAIVSLINDIAAQTNLLALNATIEAARAGDAGKGFAVVANEVKNLANQTARATEDITSQVAHIQEVAAEAIKAIQEITRTVSQIEETSSAVAGAVEEQNAVTVEIARNVAEAATGTSSVSSAIITVQATAAEATESAGQVADAASELSRQSENLSREVDGFIARIGGR
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through variation of methylation levels.  Attractants increase the level of methylation while repellents decrease the level of methylation.
What are the official names of this protein?
Methyl-accepting chemotaxis protein Amb0994, Putative torque-sensing protein Amb0994.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Found predominantly at cell poles or at septa where divison occurs.
Protein: TERH_ASPTN
Sequence: MTVSSSIVPPGGLVLVTGVTGFIGSYIANGLLELGYRVRGTVRSSEKATWVTKALTKRNPSANFEAVIVPDQNAPGVWEAVLKDVDGIAHVAGDVSFGPDPTKVITPSVEALRRLLEAAKKEPSVKRFVFTSSDQAASNRSTTREILINEDTWNEEAIEAAWRPPPYEAERGWDVYSALKAQVEKEMWRFSREEKPSFVVNSVLPTYTIGAIFDEQQAGSTAKWLLDFYKDPSKDGFMRGFGSSYYVYVGDVALLHIGALTLEEVQNKRLLAFAGRFNFNSWLEVFRKHDPSKPWPEDDPTQALDTRRVNGETELYILKQFGKDGWTSFEDSALKVLESP
What is the function of this protein?
NAD-dependent epimerase/dehydratase; part of the gene cluster that mediates the biosynthesis of terrein, a fungal metabolite with ecological, antimicrobial, antiproliferative, and antioxidative activities (PubMed:24816227).  The first step in the pathway is performed by the polyketide synthase terA that produces 4-hydroxy-6-methylpyranon (4-HMP), orsellinic acid (OA), and 2,3-dehydro-6-hydroxymellein (2,3-dehydro-6-HM) by condensing acetyl-CoA with two, three, or four malonyl-CoA units, respectively (PubMed:24816227).  4-HMP and OA are not pathway intermediates, but are rather shunt or side products (PubMed:24816227).  2,3-dehydro-6-HM is further converted to 6-hydroxymellein (6-HM) by the 6-hydroxymellein synthase terB (PubMed:24816227).  The monooxygenases terC and terD, the multicopper oxidase terE and the Kelch-like protein terF are then involved in the transformation of 6-HM to terrein (PubMed:24816227).  Even if they are co-regulated with the other terrein cluster genes, terH and terI seem to be dispensable for terrein production; whereas one or both of the 2 transporters terG and terJ are probably required for efficient secretion of metabolites (PubMed:24816227).
What are the official names of this protein?
NAD-dependent epimerase/dehydratase terH, Terrein biosynthesis cluster protein terH.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HEMA_I00A0
Sequence: MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKASPANDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSNHEASSGVSSACPYQGKSSFFRNVVWLIKKNSAYPTIKRSYNNTNQEDLLILWGIHHPNDAAEQTKLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAIMKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNTPQRERRRKKRGLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNECMESVKNGTYDYPQYSEEARLNREEISGVKLESMGTYQILSIYSTVASSLALAIMVAGLSLWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: GSHR_NOSS1
Sequence: MTFDYDLFVIGAGSGGLAASKRAASYGAKVAIAENDLVGGTCVIRGCVPKKLMVYGSHFPALFEDAAGYGWQVGKAELNWEHFITSIDKEVRRLSQLHISFLEKAGVELISGRATLVDNHTVEVGERKFTADKILIAVGGRPIKPELPGMEYGITSNEIFHLKTQPKHIAIIGSGYIGTEFAGIMRGLGSQVTQITRGDKILKGFDEDIRTEIQEGMTNHGIRIIPKNVVTAIEQVPEGLKISLSGEDQEPIIADVFLVATGRVPNVDGLGLENAGVDVVDSSIEGPGYSTMNAIAVNEYSQTSQPNIYAVGDVTDRLNLTPVAIGEGRAFADSEFGNNRREFSHETIATAVFSNPQASTVGLTEAEARAKLGDDAVTIYRTRFRPMYHSFTGKQERIMMKLVVDTKTDKVLGAHMVGENAAEIIQGVAIAVKMGATKKDFDATVGIHPSSAEEFVTMR
What is the function of this protein?
Maintains high levels of reduced glutathione in the cytosol.
What are the official names of this protein?
Glutathione reductase, GR, GRase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDP_ALIFM
Sequence: MPLSVEQALANFSQRYVEAWKAQHDCLPINEELVGLASPCIEETRDLEISWQPIVRDEAIRLHNIEQGIELDLHDDFHAFYGTQYSADMTAKFEDMNIELLQVWSDEDLERLQGNMLGHLVMQRRLKLVPTLFVAVTDDEMEVVSICNQSGEVILERVGTKNRTVLAANMAEFLNKLEPVIAA
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: BBOF1_MACFA
Sequence: MPSKGKDKKKGKSRGKDTKKLIKTDESVVDRAKANASLWEARLEITELSRIEYRDTSRTLAKSNEDLKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQKYTRQIDELEGQFHQKAKEIGMIHTELKAVRQFQRRKIQVERELDDLKENLRNTERIHQETLRRLESRFFEEKHRLKQEAEKKIIMLAERAHHEAVVQLNDAGRNVFKENVYLQKALAYHLKEAGGLQKNSQKLQESHALLLHQKEINDLLIKEKIMQLVQQRSQIQTLQKKVVNLETALGYMTKEFESEVLKLQQHAMIENQAGQVEIDKLQHLLQMKDREMNRVKKLAKNILDERTEVERFFLDALHQVKQQILISRKHYKQIAQAAFNLKMRAACAGRTEYPKIRTFDGREHSTNSVNQDLLEAEKWTHIEGNVDIGDLTWEQKEKVLRLLFAKMNGCPSRKYNQSSKPPVPDYVVSDSGETKEFGDESKLQDKIFITQQIPISDSSGKVVLPTIPKGPQESDTGTF
What is the function of this protein?
Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow.  May act by mediating a maturation step that stabilizes and aligns cilia orientation.  Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity).
What are the official names of this protein?
Basal body-orientation factor 1, Coiled-coil domain-containing protein 176.
What is the protein family that this protein belongs to?
Belongs to the BBOF1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to a polar structure adjacent to the basal body.
Protein: COAD_NOSS1
Sequence: MIAIYPGSFDPITLGHLDIIQRGSRLFDLVIVAVLRNPSKVPLFSVQERLEQIRRTTKHLPNVEADGFDGLTVNYAQQRQAQVLLRGLRAISDFEVELQMAHTNKTLSTQIETVFLATSNEYSFLSSSVVKEIARFGGSVDHLVPPHIALDIYKCYNHNYPTANPTTMEITPPHQNMATVAPQEILQEQET
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZP2_PIG
Sequence: MACRHRGDSGRPLSWLSASWRSLLLFFPLVTSVNSIGVNQLVNTAFPGIVTCHENRMVVEFPRILGTKIQYTSVVDPLGLEMMNCTYVLDPENLTLKAPYEACTKRVRGHHQMTIRLIDDNAALRQEALMYHISCPVMGAEGPDQHSGSTICMKDFMSFTFNFFPGMADENVKREDSKQRMGWSLVVGDGERARTLTFQEAMTQGYNFLIENQKMNIQVSFHATGVTRYSQGNSHLYMVPLKLKHVSHGQSLILASQLICVADPVTCNATHVTLAIPEFPGKLKSVNLGSGNIAVSQLHKHGIEMETTNGLRLHFNQTLLKTNVSEKCLPHQLYLSSLKLTFHSQLEAVSMVIYPECLCESTVSLVSEELCTQDGFMDVKVHSHQTKPALNLDTLRVGDSSCQPTFKAPAQGLVQFRIPLNGCGTRHKFKNDKVIYENEIHALWADPPSAVSRDSEFRMTVRCSYSSSNMLINTNVESLPSPEASVKPGPLTLTLQTYPDNAYLQPYGDKEYPVVKYLRQPIYLEVRILNRTDPNIKLVLDDCWATSTEDPASLPQWNVVMDGCEYNLDNHRTTFHPVGSSVTYPNHHQRFDVKTFAFVSGAQGVSQLVYFHCSVFICNQLSPTFSLCSVTCHGPSRSRRATGTTEEEKMIVSLPGPILLLSDGSSLRDAVNSKGSRTNGYVAFKTMVAMVASAGIVATLGLISYLHKKRIMMLNH
What is the function of this protein?
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy.  The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4.  ZP2 may act as a secondary sperm receptor.
What are the official names of this protein?
Zona pellucida sperm-binding protein 2, Zona pellucida glycoprotein 2, Zp-2, Zona pellucida protein A, pZP1.
What is the protein family that this protein belongs to?
Belongs to the ZP domain family. ZPA subfamily.
What are the subcellular locations of this protein?
[Processed zona pellucida sperm-binding protein 2]: Zona pellucida. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Protein: KGUA_DECAR
Sequence: MAGNLFVVAAPSGAGKTTLVRMLLEQESSVNLSISYTTRHPRPGEQNGREYHFVETPEFRAMIARQEFLEWAEVHGNFYGTSKKWIADQLAAGRDVLLEIDWQGAQQVRALFPQAIGVFILPPSMEELTRRLTGRGTDSPDVIDRRLAAAQAEMRHVGEFDYVIINDQLAQALDDLRAVVRASGLSFGAQRARHAALFERMI
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGB_RHIRD
Sequence: MKKPLNSAEEKKTGDITKAEIEAIKSGLHSNPFQIIPLHETPEGFSARCFIPGAEEVSVLTLDGNFVGELKQIDPDGFFEGRIDLSKRQPVRYRACRDDAEWAVTDPYSFGPVLGPMDDYFVREGSICGYSTGWARIPLKLEGVEGFHFAVWAPNGRRVSVVGDFNNWDGRRHVMRFRKDTGIWEIFAPDVYACAYKFEILGANGELLPLKADPYARRGELRPKNASVTAPELTQKWEDQAHREHWAQVDQRRQPISIYEVHAGSWQRSEDGTFLSWDELEAQLIPYCTDMGFTHIEFLPITEHPYDPSWGYQTTGLYAPTARFGDPEGFARFVNGAHKVGIGVLLDWVPAHFPTDEHGLRWFDGTALYEHADPRQGFHPDWNTAIYNFGRIEVMSYLINNALYWAEKFHLDGLRVDAVASMLYLDYSRKEGEWIPNEYGGRENLESVRFLQKMNSLVYGTHPGVMTIAEESTSWPKVSQPVHEGGLGFGFKWNMGFMHDTLSYFSREPVHRKFHHQELTFGLLYAFTENFVLPLSHDEVVHGKGSLIAKMSGDDWQKFANLRSYYGFMWGYPGKKLLFMGQEFAQWSEWSEKGSLDWNLRQYPMHEGMRRLVRDLNLTYRSKAALHARDCEPDGFRWLVVDDHENSVFAWLRTAPGEKPVAVICNLTPVYRENYYVPLGVAGRWREILNTDAEIYGGSGKGNGGRVQAVDAGGEIGAMLVLPPLATIMLEPEN
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: MUTS_ACTPJ
Sequence: MTQDLSKHTPMMAQYLQLKAQNPDILLFYRMGDFYELFYDDAKKAAALLDISLTKRGASAGEPIPMAGVPYHAVEGYLAKLVSLGESVAICEQIGDPATSKGPVERKVVRIVTPGTVSDEALLPERQDNLVAAIYEEKGVFAIATLDMTSGRFLITELPNKEALAAELQRLQLAEILYAEDFSAAEILNNYKGLRRRPVWEFELVTAINLLNRQFGTQSLAGFGVEKAVVALCAAGCVLHYAQETQRTALPHINSIHLAQNSDTVLLDAATRRNLELTQNLAGGTENTLAAVLDKCVTPMGSRLLKRWIHQPIRDLEKLKKRQDIIDTLQKEQRIEPLQPLLQNVGDMERILARVALRSARPRDLTRLRTALAQLPDIAKNAKNLTASLDALVAQIGDFSELHALLERAIIETPPQLIRDGGVIAEGYNAELDEWRELSAGATQYLENLEIREREATGIDTLKIGFNAVHGYYIQISQGQAHKAPMHYVRRQTLKNAERYIIPELKTYEDKVLKAKGASLALEKQLYDELFDLLMPRLGEMQLAAMALSELDVLTNLAERAESLNYVRPTFSLQRGVNIKGGRHPVVEQVLKDPFIANPVFLNAQRHLLVVTGPNMGGKSTYMRQIALISLMAYIGSFVPADSAEIGALDRIFTRIGASDDLASGRSTFMVEMTEMANILHQATENSLVLIDEIGRGTSTYDGLSLAWACAEWLAKKTQSLTLFATHYFELTSLPSQLKGVANVHLDAREHQDSIVFMHSVQEGAASKSYGLAVAALAGVPKQVIQLAKQRLAHLEEISLQTKEAHDNPQGDLLFAADLQETPQIQPLVAQQSELEKALMSIDPDELTPRQALEALYRLKKLMA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RL36_CERSK
Sequence: MKVANSLRSLKLRHRDCQVVRRKGRVYVINKTQKRYKARQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: ADNT1_ARATH
Sequence: MASEDVKRTESAAVSTIVNLAEEAREGVKAPSYAFKSICKSLFAGGVAGGVSRTAVAPLERMKILLQVQNPHNIKYSGTVQGLKHIWRTEGLRGLFKGNGTNCARIVPNSAVKFFSYEQASNGILYMYRQRTGNENAQLTPLLRLGAGATAGIIAMSATYPMDMVRGRLTVQTANSPYQYRGIAHALATVLREEGPRALYRGWLPSVIGVVPYVGLNFSVYESLKDWLVKENPYGLVENNELTVVTRLTCGAIAGTVGQTIAYPLDVIRRRMQMVGWKDASAIVTGEGRSTASLEYTGMVDAFRKTVRHEGFGALYKGLVPNSVKVVPSIAIAFVTYEMVKDVLGVEFRISD
What is the function of this protein?
Mitochondrial adenylate carrier that catalyzes specifically the transport of ATP, ADP and AMP by a counter-exchange mechanism across the inner mitochondrial membrane.  Substrate preference in reconstituted proteoliposomes is ATP > AMP > ADP.  May play a role in oxidative phosphorylation and be important for the provision of energy required to support growth in heterotrophic tissues.
What are the official names of this protein?
Mitochondrial adenine nucleotide transporter ADNT1, Adenine nucleotide transporter 1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TRML_POLSJ
Sequence: MFNIVLVEPEIPPNTGNVIRLAANTGCRLHLVEPLGFSMDDKHMRRAGLDYHEYAQVLRHASWQALLDSQRPPAGRLFAMTTHGAGSVYDMRFLPGDWLVFGAETRGLAPDVRESFPMAQRLRVPMQPGQRSLNLSNTVAVTVFEAWRQNGFAGSHHPAAADQG
What is the function of this protein?
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA).  Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.
What are the official names of this protein?
tRNA (cytidine(34)-2'-O)-methyltransferase, tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JANP_PENJA
Sequence: MSALIIQLSRVVGTLREEAGFLWKYAAFMVFIYLLLPKPAYKTNVRVPTIKFMSPWLPGIISRLLFNSKAPSVIYDGYSKYKTSAYKLLKPDGDLVVLSTRYAEELRQLPASTLNALEATFSDHVGEYTTILTDSHLHTETIQKRLTPAIGRLIPRIISELDYAFQVEFPNCDNQFVAINSYEVFLRLVARVGARIFIGDELCREEKWLKASIDYTKNIFLTIALLRPFPGFLHPIVGRILPSSRSLDRQLVYIKEELLGPLINKRRSLEAVSDSNYEKPDDFLQWMMDLAKTEKESHPHNLAQRLLGITSMAVVHTSAMSMTHILYDLLVMPQWVQPLRDEIQTEIADWRSTTQSNLNNLRVMDSFLKESQRFNPPGELSFHRVVKHDLTLSDGLLLPKGTHICMAAGPISMDPEVVENPDVFDAFRFVKEKVPTSGFVSTGPSHMHFGLGRYACPGRFFASIVMKLILSRFLAQYEFHFAPDQTERPRNLLIGDKIVPNVSTPIFIKNRAPEI
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes janthitremanes such as shearinine K or shearinine A (PubMed:26213965).  The geranylgeranyl diphosphate (GGPP) synthase janG catalyzes the first step in janthitremane biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:26213965).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase janC then forms 3-geranylgeranylindole (3-GGI) (PubMed:26213965).  Epoxidation by the FAD-dependent monooxygenase janM leads to a epoxidized-GGI that is substrate of the terpene cyclase janB for cyclization to yield paspaline (PubMed:26213965).  Paspaline is subsequently converted to 13-desoxypaspaline by the cytochrome P450 monooxygenase janP, via beta-PC-M6 in a series of alpha-face oxidations (Probable).  The cytochrome P450 monooxygenase janQ is proposed to carry out sequential beta-face oxidation steps at C-7 and C-13 of 13-desoxypaspaline to form paspalicine and paspalinine respectively (Probable).  The indole diterpene prenyltransferase janD may then convert paspalinine into shearinine K which is substrate of janO and/or additional enzymes for oxidation and cyclization to generate shearinine A (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase janP, Janthitremanes biosynthesis cluster protein P.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AG_SOLLC
Sequence: MDFQSDLTREISPQRKLGRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVVFSNRGRLYEYANNSVKATIERYKKACSDSSNTGSVSEANAQYYQQEASKLRAQIGNLMNQNRNMMGEALAGMKLKELKNLEQRIEKGISKIRSKKNELLFAEIEYMQKREVDLHNNNQYLRAKIAETERAQHQHQQMNLMPGSSSNYHELVPPPQQFDTRNYLQVNGLQTNNHYPRQDQPPIQLV
What is the function of this protein?
Probable transcription factor involved in regulating genes that determines stamen and carpel development in wild-type flowers.
What are the official names of this protein?
Floral homeotic protein AGAMOUS, TAG1.
What are the subcellular locations of this protein?
Nucleus.
Protein: THI7_YEAST
Sequence: MSFGSKVSRALRFLEIPVKDRASVSFLKNPDLQPIKSANQTWGFWSNFAYWGVMSFSVGTWMSASSALGVGLSYPETIGTFIVGDVLTIIFTLANSCPGYDWKVGFTLAQRFVFGIYGSAFGIIIRILMSIVNYGSNAWVGGLCINMILDSWSHHYLHLPNTLSSKVAMTTKELIGFIIFHVLTAFCYLMKPYHMNYILIWSCVATFFSMLGMVIYLAKQAHGVGELFTSTKSTATGSTKAWAWVYMISYWFGSVSPGSTNQSDYSRFGSSNWAIWAGTICALLIPTTLIPVFGVIGASTCDKLYGEQYWMPMDIFNHWLTTNYSAGARAGAFFCGLSFVLSQMSYTISNCGFASGMDLAGLLPKYVDIKRGALFAACVSWACLPWNFYNSSSTFLTVMSSFGVVMTPIISVMICDNFLIRKRQYSITNAFILKGEYYFTKGVNWRAIVAWVCGMTPGLPGIAWEVNNDYFHNTGIVNFFYGDSFFSFLISFFVYWGLCLLFPFKITVKHDDKDYYGAFTDEEARKKGMVPYSEISEEEIRAYTLGEGYTTGHEYRPEGSDDEIPELVKTSSENTNEFEIVHHKNNEKQSSTASEKAA
What is the function of this protein?
Responsible for intake of thiamine.
What are the official names of this protein?
Thiamine transporter.
What is the protein family that this protein belongs to?
Belongs to the purine-cytosine permease (2.A.39) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: REX_THEP1
Sequence: MAEKIPKPVSKRLVSYYMCLERLLDEGVEVVSSEELARRLDLKASQIRKDLSYFGEFGKRGVGYNVEHLYDAIGEILGVKKEWKLVVVGAGNIGRAVSNYAVMREKGFKIVGIFDSDPSKMGKEAAPGLTVSDVSELEKFVEEHGVEIGVIAVPAEHAQEIAERLEKAGIMGILNFAPVKIKVSVPVENIDITASLRVLTFEIVRRNN
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_ACIBC
Sequence: MDENKSKALQAALSQIEKQFGKNTVMRLGDNTVQAVEAVSTGSLTLDIALGIGGLPKGRIIEIYGPESSGKTTMTLQAIAQCQKSGGTCAFIDAEHALDPQYARKLGVDIDNLLVSQPDNGEQALEIADMLVRSGAIDLIVVDSVAALTPKAEIEGEMGDSHMGLQARLMSQALRKITGNAKRSNCMVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGQVKEGDEIVGSETKVKVVKNKMAPPFKEAIFQILYGKGTNQLGELVDLAVQQDIVQKAGAWYSYQGNKIGQGKNNVIRYFEENTQIAEEIERNIREQLLTTGTNGAVQIEDEEEPDLLLES
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_SYNP6
Sequence: MSQEDIFSKVKDIVAEQLSVDVAEVKPESSFQNDLGADSLDTVELVMALEEAFDIEIPDEAAEGIATVQDAVDFIASKAA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPQ_SHEB9
Sequence: MDQLAHHYRAHIAELNRRVAEILSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQLIFYRPVDFWHKVSDVPDMFWTEYFDIKLLTKADKVAEFLPTDIANWAYLGEHLDVAEVLGFTSRNPDAVMSYLHYHRTTKTEYELECMRRANQIAVQGHLAAKNAFYNGASEFEIQQHYLSAVGQSENEVPYGNIIALNQNAAILHYTALEHQSPAKRLSFLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHAKVAQMLLDFDLATGDVQGLIDQGITSAFFPHGLGHMLGLQVHDVGGFSHDERGTHIAAPEAHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGQQINWQTVDELRPFGGIRIEDNVIVHQDRNENMTRELGLTD
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: TADBP_XENTR
Sequence: MEMEYIRVAEDENEEPMEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVNQCMRGVRLVEGILHAPENGWGNLVYVVNYPKDNKRKMDETDASSAVKIKRAVTKTSDLIVLGLPWKTTEQDLKDYFSTFGEVIMVQVKKDAKTGHSKGFGFVRFADYETQVKVMSQRHMIDGRWCDCKLPNSKSPDEPMRSRKVFVGRCTEDMSAEELRQFFSQYGEVVDVFIPKPFRAFAFVTFADDQVAQSLCGEDLIIKGVSVHVSTAEPKHNNNRQLERGGRFPGPSFGNQGYPNSRPSSGALGNNQGGNMGGGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPQGSNQGQGNQQRDQPQSFGSNNSYGSNSGAIGWGSPNAGSGSGFNGGFSSSMESKSSGWGM
What is the function of this protein?
Probably involved in transcriptional repression (By similarity).  May play a role in the maintenance of the circadian clock periodicity.
What are the official names of this protein?
TAR DNA-binding protein 43, TDP-43.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, Stress granule. Mitochondrion. Note=Continuously travels in and out of the nucleus. Localizes to stress granules in response to oxidative stress. A small subset localizes in mitochondria.