PharMolix/UniProtQA huggingface dataset:
Protein: PRMA_THENE
Sequence: MRFKELVFLLKIDEEELLEKLYEEGFFNFAIEENKEGDRLLRVYLREGETLPSFLSNWKILDERLTTPKDWMVELEPFEIVEDVVVDPTEKVTRTDKIVVKLSPGVAFGTGLHPTTQMSVLFLKKYLKKGDRVVDVGCGTGILAIVAKKLGASYVLAVDVDEQAVEVAKENVQKNSVDVTVKRSDLLSEVEGVFDLVVSNILAEIHLRLLEDVSRVTHEKSILILSGIVDTKEDMVREKAQKKGWNLLERKQEREWVTLVMKRS
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINC_LISW6
Sequence: MKKNVQIKGTKDGISIFLSDKASILELQQELSQLLADKKQNPYSGEKLEVQVQIGNRLFSEEEELEISTIIHNNSQMEISAFYSNVMSKDDAKKWKERDQIFSMATIIRSGQVVQVPGDFLLIGDVNPGGQIRSNGNVFVLGNIKGIIHAGFEGDKNAVVAGKFLYPSQVRIADKVYGFDSEDYKEVVDTDLFSAFVNDTDEIVIDEIHKIRKIRPEISNFQGGR
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: Y2370_RHOP2
Sequence: MNTAIIYVGAAIAEIAGCFAFWGWLRLGKPVWWLAPGLLSLALFAYLLTLVESEAAGRAYAAYGGIYIVASLAWLWSVEGVRPDRWDVSGACVCLAGAAIILWGPRG
What are the official names of this protein?
UPF0060 membrane protein RPB_2370.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAJ_BORPE
Sequence: MAKRDYYEVLGVAKNASDEDLKKAYRKLAMKYHPDRNPDSKEAEEKFKEAKEAYEVLGDEQKRAAYDRYGHAGVDPNAAGMGGGMGGGMGGGMGGGMGGGFADAFGDIFGEIFGAGRRGGGGPQVYRGADLKYALEITLEQAASGFDTEIRVPSWENCDTCHGSGAKAGTSPKTCRTCGGSGAVRMQQGFFSVQQTCPTCHGTGKEITDPCPSCDGVGRTRRNKTLQVKIPAGIDDGMRIRSSGNGEPGINGGPPGDLYVEIHIKQHKIFQRDGDDLHCELTIPFTTAALGGELQVPTLGGKAEISIPEGTQSGKTFRLRAKGIRGVRGSYPGDLYCHVVVETPVRLSDEQKAILRQFEASLNDGGDRHSPQSKSWTDRVKEFFS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSL1_HUMAN
Sequence: MTMRSAVFKAAAAPAGGNPEQRLDYERAAALGGPEDEPGAAEAHFLPRHRKLKEPGPPLASSQGGSPAPSPAGCGGKGRGLLLPAGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPAAAGAGCSPRPKYQAVLPIQTGSLVAAAKEPTPWAGDKGGAASPAATASDPAGPPPLPLPGPPPLAPTATAGTLAASEGRWKSMRKSPLGGGGGSGASSQAACLKQILLLQLDLIEQQQQQLQAKEKEIEELKSERDTLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHKRKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEIEDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHAKLELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLMITPFLPVVAFGRPLPKLTPQNFELPWLDERSRCRLEIQKKQTPHRTCRK
What is the function of this protein?
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571).  Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816).  This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816).  In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026).
What are the official names of this protein?
Male-specific lethal 1 homolog, MSL-1, Male-specific lethal 1-like 1, MSL1-like 1, Male-specific lethal-1 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the msl-1 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Nucleus speckle.
Protein: YEF5_YEAST
Sequence: MKCHAKRTLAFLATALPLSGKSRACTRTPQSFASGFRAAAPFLFSRCFALCITHCALFHLPYSFTGFSFYFFVFFRLFLHWIYAFCICNSTYVYIYKQVLSLPVKSSMCPSRLSCSVWYRVILTYIYVHCFRWLVRNHLLS
What is the function of this protein?
Required for optimal growth under alkaline conditions.
What are the official names of this protein?
Uncharacterized protein YEL045C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FOXP2_MACMU
Sequence: MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHSIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE
What is the function of this protein?
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium.  May also play a role in developing neural, gastrointestinal and cardiovascular tissues.  Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential.  Plays a role in synapse formation by regulating SRPX2 levels (By similarity).
What are the official names of this protein?
Forkhead box protein P2.
What are the subcellular locations of this protein?
Nucleus.
Protein: OTSA_SALCH
Sequence: MSRLVVVSNRIAPPDNKGGAGGLAVGVLGALKAAGGLWFGWSGETGNEDEPLKKVTKGNITWASFNLSEQDYEDYYCQFSNAVLWPAFHYRLDLVQFQRPAWEGYMRVNALLADKLLPLIKENDIIWVHDYHLLPFASELRKRGVNNRIGFFLHIPFPTPEIFNALPPHDELLEQLCDFDLLGFQTENDRLAFLDSLLSQTRVTTRSGKQHIAWGKDFQTEVYPIGIEPDEIALQAAGPLPPKLAQLKAELKNVKNIFSVERLDYSKGLPERFLAYEALLENYPQHRGKIRYTQIAPTSRGEVQAYQDIRHQLETEAGRINGKYGQLGWTPLYYLNQHFDRKLLMKIFRYSDVGLVTPLRDGMNLVAKEFVAAQDPANPGVLVLSQFAGAANELTSALIVNPYDRDDVAAALNRALTMPLAERISRHAEMLDVIVKNDINRWQERFIHDLKEVTPRSPERQQQNNVATFPKLA
What is the function of this protein?
Probably involved in the osmoprotection via the biosynthesis of trehalose.  Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate.  Acts with retention of the anomeric configuration of the UDP-sugar donor.
What are the official names of this protein?
Trehalose-6-phosphate synthase, TPS, Alpha,alpha-trehalose-phosphate synthase [UDP-forming], Osmoregulatory trehalose synthesis protein A, OtsA, UDP-glucose-glucosephosphate glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 20 family.
Protein: COFC_METMJ
Sequence: MYFHALIPFKPVNPKTRLSCILNQEEREAFARAMLEDVIAAVQKSGCSATLLCTHSFKHENALVAVRTEPLNDAINWALGQFHCPALIIMGDIPLVTAGDIQRLIRTEKDMSIVPGRGGGTNIIFLKKPRCFRADYYGASFLDHMRIAEECGFSVEVIDSFRMSTDIDEKEDLVEILIHGKGRRSREYLENSGFSIALDEKGRVGVQRDPHEEAL
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
2-phospho-L-lactate guanylyltransferase, LP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: CARME_RAT
Sequence: MQRRRRAPPASQPAQDSGHSEEVEVQFSAGRLGSAAPAGPPVRGTAEDEERLEREHFWKVINAFRYYGTSMHERVNRTERQFRSLPDNQQKLLPQFPLHLDKIRKCVDHNQEILLTIVNDCIHMFENKEYGEDANGKIMPASTFDMDKLKSTLKQFVRDWSGTGKAERDACYKPIIKEIIKNFPKERWDPSKVNILVPGAGLGRLAWEIAMLGYACQGNEWSFFMLFSSNFVLNRCSEVDKYKLYPWIHQFSNNRRSADQIRPIFFPDVDPHSLPPGSNFSMTAGDFQEIYSECNTWDCIATCFFIDTAHNVIDYIDTIWRILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVLQYGFQLEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ
What is the function of this protein?
N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine.  Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles.  Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
What are the official names of this protein?
Carnosine N-methyltransferase, Anserine-producing methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the carnosine N-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: RL3_BACC0
Sequence: MTKGILGRKIGMTQVFAENGELIPVTVIAANPNVVLQKKTTETDGYNAIQLGFEDKREKLTNKPEQGHTAKASTTPKRFIREIRDADVDGLEVGQEVKVDVFATGEIVDVTGISKGKGFQGVIKRHGQSRGPMSHGSRYHRRPGSMGPVAPNRVFKGKKLAGRMGGDQVTIQNLEIVQVDTERNLLLVKGNVPGAKKSLVVVQGAVKVSK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RAD59_ASHGO
Sequence: MSDYTNVSWDNVTYYGGNGVALDELELKVSWHNRPASSWSVRRIGALQHKIEQYTFKIYHVNRYGKHSLSQVIPTHVLIQFANEAFGYNGWSSAVEEVLITDVKQRERVRDGAAIELYTVTAEARVKLTLQDGTNTEATGLSKITLPSKGDAYGKAKKEASADALKRCLLSFEGIVIEHEQKVASNYYTDGEFGSRKAGDKRDR
What is the function of this protein?
Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing.  Anneals complementary single-stranded DNA (By similarity).
What are the official names of this protein?
DNA repair protein RAD59.
What is the protein family that this protein belongs to?
Belongs to the RAD52 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RMT2_CRYNJ
Sequence: MDMDSAHLDSSLLTLAFRLIKAAQTAAPSVLADLLAEGAPAWFQDDDLGWSCLHYAAERKEPECLEVLLQGGAVWNAVDKWGRTAGEICLSLGDEEGWSIIRNEGIRSEDKTSAGDNLVFLKSKLTWDVGKDGKERVLDADGNGVMMGWEEPLSYCIVVEHVKRLTEEHPKAELGAEGMSILNVGFGLGIVDRLFQECDPKPSHHTIIEAHPQVLEYIHKKGVHLLPNVRILQGRWQDWLLDGEKVGDVLSGTPDGMGFDAIFVDTFAEGYEDLKAFFEVIPDILNADNGRFSFWNGLGATNPTIYAVSSSLAELHLEDVGLQVEWHDVLIPESMREEVWKGVRRRYWDLPGYRLPIAKMSLI
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins.  Monomethylates ribosomal protein L12.
What are the official names of this protein?
Protein arginine N-methyltransferase 2, Protein-arginine N5-methyltransferase, Type IV protein arginine N-methyltransferase, Type IV PRMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BTUC_YERPY
Sequence: MQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFVWQLRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGVALGIICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSLHLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLADVVARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Involved in the translocation of the substrate across the membrane.
What are the official names of this protein?
Vitamin B12 import system permease protein BtuC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: URE1_YERPY
Sequence: MPQISRQEYAGLFGPTTGDKIRLGDTNLFIEIEKDLRGYGEESVYGGGKSLRDGMGANNNLTRDNGVLDLVITNVTIVDARLGVIKADVGIRDGKIAGIGKSGNPGVMDGVTQGMVVGVSTDAISGEHLILTAAGIDSHIHLISPQQAYHALSNGVATFFGGGIGPTDGTNGTTVTPGPWNIRQMLRSIEGLPVNVGILGKGNSYGRGPLLEQAIAGVVGYKVHEDWGATANALRHALRMADEVDIQVSVHTDSLNECGYVEDTIDAFEGRTIHTFHTEGAGGGHAPDIIRVASQTNVLPSSTNPTLPYGVNSQAELFDMIMVCHNLNPNVPADVSFAESRVRPETIAAENVLHDMGVISMFSSDSQAMGRVGENWLRILQTADAMKAARGKLPEDAAGNDNFRVLRYVAKITINPAITQGVSHVIGSVEVGKMADLVLWDPRFFGAKPKMVIKGGMINWAAMGDPNASLPTPQPVFYRPMFGAMGKTLQDTCVTFVSQAALDDGVKEKAGLDRQVIAVKNCRTISKRDLVRNDQTPNIEVDPETFAVKVDGVHATCEPIATASMNQRYFFG
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GADE_SHIFL
Sequence: MIFLMTKDSFLLQGFWQLKDNHEMIKINSLSEIKKVGNKPFKVIIDTYHNHILDEEAIKFLEKLDAERIIVLAPYHISKLKAKAPIYFVSRKESIKNLLEITYGKHLPHKNSQLCFSHNQFKIMQLILKNKNESNITSTLNISQQTLKIQKFNIMYKLKLRRMSDIVTLGITSYF
What is the function of this protein?
Regulates the expression of several genes involved in acid resistance.  Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions.  Binds directly to the 20 bp GAD box found in the control regions of both loci (By similarity).
What are the official names of this protein?
Transcriptional regulator GadE.
Protein: PSPB_PENSO
Sequence: MVLNHSPPPGLYITGLGSQYPPYLLGPEKLEEFAARFYDVESPGLKKLLQINRSSGIETRSAIRSYESGFATRPEAPTISELAEFYHQAGVDLTTQACKKALRESQISPQHVTHTIGVTCTNQGNPGFDLLVNRKLGLSANVDRMLLHGVGCAGGLAIMRAAAQIACGASMRRKPVRILAFACELCTPNVRHDLAFAEKAPNAENISIAGALFSDAAAAFVLCNEYAMAETEITPLFQLLEWGNSLIPDTVEHMAFFADVDGYRTVLTRDVPQYTKHAIGPMFEKLLPSYQSQIQSSSGEGVGEVAKSLGVSDFDWALHPGGEAIIEGAKQVLGLTEDQLQASREIYRTRGNSSSATVLIVLDRLRSLGKREYVVATSFGPGLAIEMAMLRRCEVDED
What is the function of this protein?
Type III polyketide synthase; part of the gene cluster that mediates the biosynthesis of the alkylresorcinols called soppilines (PubMed:31086874).  The biosynthesis starts with the HR-PKS pspA-catalyzed carbon chain assembly through nine chain elongation cycles, using acetyl CoA and malonyl CoA as a starter and extender units, respectively, to produce the polyketide soppiline A (PubMed:31086874).  In the first round, the KR, DH, and CMeT domains work to produce 2-methyl-2-butenyl thioester (PubMed:31086874).  In rounds 2 to 5, the KR, DH, and ER domains fully catalyze the reduction of the elongated beta-ketothioester, resulting in the insertion of eight methylene units (PubMed:31086874).  The unusual Z,E,Z-triene motif is likely constructed during rounds 6 to 8 (PubMed:31086874).  Typically, the DH domain introduces a double bond at an alpha,beta-position of an elongated polyketide chain, with the dehydration of a beta-hydroxy group (PubMed:31086874).  The last extension cycle would be carried out with L-oriented beta-ketoreduction by the KR domain to produce beta-hydroxy carboxylic acid soppiline A (PubMed:31086874).  The type III PKS pspB intercepts the elongated polyketide chain at round 8 from the HR-PKS pspA, followed by a tri-keto extension and decarboxylative aldol cyclization to produce 1,3,5-trisubstituted alkylresorcinol soppiline B (PubMed:31086874).  Subsequently, the cytochrome P450 monooxygenase pspC catalyzes three-step oxidations at the C-4 methyl group to carboxylic acid to yield soppiline C (PubMed:31086874).
What are the official names of this protein?
Type III polyketide synthase pspB, Soppiline biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: GLGB_BRADU
Sequence: MPRAKPMPKLPAEAYAIIEGRHADPFHYLGLHPEGGKSVVRAFLPEASNVEAVGEHGEVARLDRVHDAGLFVGALPNGSKHYQLRAKFGDSIVEFEDAYRFPPILTDFDLYLLGEGTHQRLYDKLGAHPMTLDGVDGIGFVVLAPNARRVSVVGDFNFWDSRRHPMRVRGSGYWELFIPHAKRGDHYKFDIVGPHGHQLPLKSDPMAFASEVRPKTASIVFDEAHLPRPRPAPDGINALSAPMSIYEVHLGSWRRKGDNEWLTYRELAEQLPAYARDMGFTHLEFLPVSEHPFDGSWGYQPTGLYAPTSRFGTPEDFAALVDACHREGVGVLLDWVPGHFPDDPHGLGSFDGTSLYEHANPLQGRHLDWGTLIYNYGRTEVTNFLVSNALFWLERYAIDGLRVDAVASMLYLDYSRPPGAWIPNQYGGRENIEAIAFLRRFNTELFARFPQATTAAEESTAWPQVSRPVEFGGLGFGYKWNMGWMHDTLNYISKDPIHRKHHHGEILFGLHYAFSENFILPLSHDEVVHGKRSILGRMPGDEWQRFANLRAYYSFMFGHPGKKLLFMGAEIAQSREWNHDQSLDWHLLEYKYHSGIQALIRDLNRLYRAVPALHQMDCDQAGFEWLITDDANRNVFAWLRKGLDEHARCLVIVNFSPNVYRNYRVRVPFAGKWKEVLNSDSAHYGGSNVGNIGEVHAVDGKTPELRLTIPPLAAIFLVPES
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: TYDP1_RAT
Sequence: MSQESSYGKWTISSSDDSEDEKPKPVKPSTSSGPQAGQGVSKEPTYTCSEARKAAHKRQISPVKFNNTDSVLPHKKQKMDSPEGLGWCLSSSDDEQQPDVTQQEQPKGVPPQEKKYAPSANVTTAQKVEDRSPPDSHRAQRADEEYETSGEGQDIWDMLDKENPFQFYLTRVSGIKAKYNSKALHIKDILSPLFGTLVSSAQFNYCFDVNWLIKQYPPEFRKKPILLVHGDKREAKADLHAQAKPYANISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIREDWHQKTQGIWLSPLYPRIYQGNHTSGESSTHFKADLTSYLMAYNAPPLQEWIDIIQEHDLSETNVYLIGSTPGRFQGSHKDNWGHFRLRKLLQAHAPSAPRGECWPVVGQFSSIGSLGPDESKWLCSEFKESLLAVREEGRTPGRSAVPLHLIYPSVENVRTSLEGYPAGGSLPYGIQTAEKQRWLHPYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKLAWFLVTSANLSKAAWGALEKNGAQLMIRSYELGVLFLPSAFGLDTFKVKQKFFSSSSEPMASFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS
What is the function of this protein?
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate.  Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue.  Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals.  Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA.  Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups.  Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).
What are the official names of this protein?
Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1.
What is the protein family that this protein belongs to?
Belongs to the tyrosyl-DNA phosphodiesterase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RN146_XENTR
Sequence: MAGCGEVSHSANMLPTNKKLVEPCPNSAPSLSVPECAICLQTCVHPVSLPCKHIFCYLCVKGASWLGRRCALCRQEIPEDFLDKPTLLSPEELKSASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFTKGKKSTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIVDIPKKGVAGLRLECDAANVNLARESSADGADNMAALGASSSQPTPVLPTRLHTSLSTTASHALSHSDVTSSLENSFAQLQIGDPVIGRNNIGEGEEGQPLINARMPAPSALLEESEPSDSNDHGSPTLQHNSLLVPQSNRLPFGNP
What is the function of this protein?
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.  May regulate many important biological processes, such as cell survival and DNA damage response.  Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated proteins.  Neuroprotective protein.  Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest.  Promotes cell survival after gamma-irradiation.  Facilitates DNA repair.
What are the official names of this protein?
E3 ubiquitin-protein ligase rnf146, RING finger protein 146, RING-type E3 ubiquitin transferase rnf146.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage.
Protein: GPR33_RATRT
Sequence: MDRVNSSGHVISVSPSLTNSTGVPTPAPKAIIAAALFMSFIVGTISNGLYLWMLKFKMQRTVNTLLFFHLILSYFISTLILPFMATSFLQDNHWAFGSVLCKVFNSTLSVSMFASVFFLSAISVDRYHLTLHPVWSQQHRTPRWASRIALRIWILATILSIPYLVFRETHDDHKGRIKCQNNYIVGTNWESSEHQTLGQWIHAACFGRRFLLGFLLPFLVIVFCYKRVATKMKDKGLFKSSKPFKVMLTAVVSFFVCWMPYHVHSGLVLTKSQPLPSQLTLGLAVVTISFNTVVSPILYLFTGENFEVFKKSILALFKSTFSDSSATERTQTLNSETEI
What is the function of this protein?
Orphan receptor; could be a chemoattractant receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 33.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IN80E_BOVIN
Sequence: MNGPADGEVDYKKKYRNLKRKLKFLIYEHECFQEELRKAQRKLLKVSRDKSFLLDRLLQYENVDEDSSDSDATASSDNSETEGTPKLSDTPAPKRKRSPPLGGAPSPSSLSLPPSTGFPLQASRAPSPYLSSLASPTYPPFPSDYLALQLPEPSPLRPKREKRPRLPRKLKMAVGPPDCPVGGPLTFPGRGSGAGVGAALAPLPPPKMPPPTILSAVPRQMFSDAGSGDDALDGDDDLVIDIPE
What is the function of this protein?
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
What are the official names of this protein?
INO80 complex subunit E, Coiled-coil domain-containing protein 95.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYT_FINM2
Sequence: MFEVKLKDGSAKEFDGEISLLDVCKSISEGLARDCVGAVVDGKIMGLMETIDSDCEVQFVKFDDDEGKQVFWHTSSHLMAYAIQRLYPGTKFAIGPSIDSGFYYDLDTDHKFVPEDLEKIEAEMKKIVKENPKLVRVEISRKEALERFKNEGQDYKVDLIENFDEDATITLYEMGDFVDLCRGPHLLDVKNIKAFKLLSIAGAYWRGDENNKMLQRIYGISFPKKKLLDEYLDRMEEAKKRDHRKIGKEMGLFSIQEEGPGFPFFHPNGMVVLNELEKFLKEQLLERGYGQIKTPLILNEHLWHQSGHWDHYKENMYFTKIDGEDYAIKPMNCPGSILVYKDELHSYRELPIKVAELGQVHRHELSGALHGLFRVRTFVQDDAHVFCLPEQIEEEVSKTIDFCDYIYSKFGFKYEVELSTRPEDSMGSDEDWDLAISSLKNALEHKGLPYKINEGDGAFYGPKIDFHLEDAIGRTWQCGTIQLDFQMPERFDMTYIASDGSKKRPAMIHRAILGSEERFMGILIEHYAGKFPLWLSPVQVEILPISDKFNDYAYELQQKMKARGLRVKVDDRSEKIGLKIRESQLKKVNYSLIIGQNEIDNNEVSVRKRDIGDVGSKNTDEFINELVDEYQNRK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.