PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_METI4
Sequence: MIESYLAFIFLNKVNKKKAPSLDSLGYEEIKKRHDELVKLIRKYDYAYYVEAHPLVSDQEYDNLYHELETLEKLHPELITPDSPTQRIGETPLSGFSQVTHEIPMLSLENTYSKEELFAFLERIKRALPGKKISFTVEPKIDGVSISAVYKNGLFSLGATRGNGTVGDDITQNLKTIRSLPLRLETPDPPEYLEVRGEAYMSPKDFERLNAQREKEGKVLFANPRNATAGSLKQLDPRVVAERPLAVVFYGAGKLVGMKCKTQEEWLNFLKKIGLPIPIVFWVCSNENEVYEAIGKLNECRNQLPYPTDGAAVKVNEWEYYSLLGYTAKAPRWAFAYKYGAERAKTRLNNVIFQVGRSGTITPVAEMDPVFLSGTTVSRATLHNFDQVKRLDVKIGDVVYLEKAGEVIPEVVGVDLNQRRGTEKEIVPPEFCPSCGEKLSWEGIFLRCENENCPAQLKERILHFAQRNAMDIQGLGESLVDQLVDKGIVKDVADIYDLDEETLVNLDRMGKKSAQNLLKAIEESKKKDLSRLIFGLGIPHIGQKASEDLARYFGTMDKLSHATEEELLNLPFIGEIMARSIVNYFRKEANRRRLEKLRKKGLNFVSTLSQASSGTLSGKTFVITGTLSEPRESIAQKIISKGGRVSNSLSRKTSYLVVGSDPGSKLQEAKKLGIPLINEQELLEMLHGG
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PME11_ARATH
Sequence: MGLYKTKSKRSIANYHHIIIINIFILSSITSSSMASSSSPSSIDFSTAILIRVDQSGKGDFSKIQEAIESIPPNLNNSQLYFIWVKPGIYREKVVIPAEKPYITLSGTQASNTFLIWSDGEDILESPTLTIFASDFVCRFLTIQNKFGTAGRAVALRVAADKAAFYGCVITSYQDTLLDDNGNHYFKNCYIEGATDFICGSASSLYERCHLHSLSPNNGSITAQMRTSATEKSGFTFLGCKLTGSGSTFLGRPWGAYSRVVFAYSFFSNVVAPQGWNQWGDSTKENTVYYGEYKCYGPGADREQRVEWSKQLSDEEATVFLSKDFIGGKDWLRPAPSHFKNAPKQTQNKEIN
What is the function of this protein?
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
What are the official names of this protein?
Putative pectinesterase 11, PE 11, Pectin methylesterase 11, AtPME11.
What is the protein family that this protein belongs to?
Belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SRC_AVIS2
Sequence: MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPPVPAWREPIGLELLLAPEASLWGTGAWLRAEGPRFGEQPQSRMWHGEVSGAPSLIKTVLGHP
What is the function of this protein?
This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro.
What are the official names of this protein?
Tyrosine-protein kinase transforming protein Src, pp60v-src, p60-Src, v-Src.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Protein: HFQ_BACAN
Sequence: MKQSINIQDQFLNQLRKENTFVTLYLLNGFQLRGLIKGFDNFTVLLETEGKQQLIYKHAISTFVPQKNVSIELE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: MYC2_ORYSJ
Sequence: MNLWTDDNASMMEAFMASADLPAFPWGAASTPPPPPPPPHHHHQQQQQQVLPPPAAAPAAAAFNQDTLQQRLQSIIEGSRETWTYAIFWQSSIDVSTGASLLGWGDGYYKGCDDDKRKQRSSTPAAAAEQEHRKRVLRELNSLIAGAGAAPDEAVEEEVTDTEWFFLVSMTQSFPNGLGLPGQALFAAQPTWIATGLSSAPCDRARQAYTFGLRTMVCLPLATGVLELGSTDVIFQTGDSIPRIRALFNLSAAAASSWPPHPDAASADPSVLWLADAPPMDMKDSISAADISVSKPPPPPPHQIQHFENGSTSTLTENPSPSVHAPTPSQPAAPPQRQQQQQQSSQAQQGPFRRELNFSDFASNGGAAAPPFFKPETGEILNFGNDSSSGRRNPSPAPPAATASLTTAPGSLFSQHTPTLTAAANDAKSNNQKRSMEATSRASNTNNHPAATANEGMLSFSSAPTTRPSTGTGAPAKSESDHSDLEASVREVESSRVVAPPPEAEKRPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELRGKLTALETDKETLQSQMESLKKERDARPPAPSGGGGDGGARCHAVEIEAKILGLEAMIRVQCHKRNHPAARLMTALRELDLDVYHASVSVVKDLMIQQVAVKMASRVYSQDQLNAALYTRIAEPGTAAR
What is the function of this protein?
Transcriptional activator involved in jasmonate (JA) signaling pathway during spikelet development.  Binds to the G2 region G-box (5'-CACGTG-3') of the MADS1 promoter and thus directly regulates the expression of MADS1.  Its function in MADS1 activation is abolished by TIFY3/JAZ1 which directly target MYC2 during spikelet development.
What are the official names of this protein?
Transcription factor MYC2, OsMYC2, Basic helix-loop-helix protein 9, OsbHLH009, bHLH 9.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AIM41_PYRTR
Sequence: MSLFRSTMLRRQLLTSRSVCLRYSSTSTPENVVLPRLQADLKNAMRSKNKPALNTIRAIQAEIINASKTAKPITTDSALYSLIQKQIKSSSASIEEFRNAKREDLVEKEQAQLDVLQGYSGEIPTVGESEIDELVKSALEGLEEGKRSAGHVMGRVMSSIKGRAVDSEYVSKKIQEVVGAK
What are the official names of this protein?
Altered inheritance of mitochondria protein 41, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AIM41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: KTHY_TROW8
Sequence: MFVTFEGIDGSGKTAQLTAAGEFLKASGKQVVLTREPGTISCIRDYVLASDMDIRTEALLYSADRAENIAKNVIPALNAGKVVLQDRYLDSFLAYQLADNKLVETDIMRLFEFSSQGLRPDLTLLFDLTPACAQERLENRDRIERKPIDFHSKVRNIYLKLSADNTDRIRVIDASQSFSKIHQQVIYHIERKLGGTHSA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RL15_STAA1
Sequence: MKLHELKPAEGSRKERNRVGRGVATGNGKTSGRGHKGQKARSGGGVRPGFEGGQLPLFRRLPKRGFTNINRKEYAIVNLDQLNKFEDGTEVTPALLVESGVVKNEKSGIKILGNGSLDKKLTVKAHKFSASAAEAIDAKGGAHEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: N4BP1_MOUSE
Sequence: MAARVVLDEFTAPAEKAALLERSRGRIEALFGVGLAVLGALGAEEPLPARIWLQLRGAQEAVHSAKEYIKGICEPELEEKECYPKAMHCIFVGAQSLFLKSLIQDTCADLCVLDTGLLGIRGSAEAVVMARSHIQQFVKLFESNENLPSNQRESEIKREFRQFVEAHADSYTMDLLILPTSLKKELLSLTQGEESLFETDDDVITVGDVRPPEYTQSAATGPSSARDEVVVQEDSRNKARTPVSELTKHMDTVFSSSPDVLFVPVNGLSPDEDALSKDRVCHKRRSSDTEERHTKKQFSLENVPEGELLPDGKGSAGNEVIDLSDPASNSTNLSPDGKDTTEEMEYNILVNFFKTMGYSQEIVEKVIREYGPSTEPLLLLEEIEKENKRLQEDRDFPPCTVYPDASQSRNAGVGSTTNELTADSTPKKAQSHTEQSMVERFSQLPFKDSKHCTSNCKVNSFRTVPVGQKQEIWGSKQNSSCTVDLETDGHSASAASASPKDISFVSRGASGHQQRNPAFPENGFQQQTEPLLPNNTKPACEKRSGSCSSPQPKPNYPPLSPPLPLPQLLPSVTEARLGGSSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRADLKHIVIDGSNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNITEQHFLTQLQELGILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVTESVSWREIITKRLLQYTFVGDIFMVPDDPLGRNGPRLEEFLRKEAFLRHMQPLLNALPSVGTFDPGFRSPSTQVANNSHQPPPRIQTSSSPWLPQQSHFTALATLPSMQQNPPLPAQRSSAETSELREALLKIFPDSEQKLKIDQILAAHPYMKDLNALSALVLD
What is the function of this protein?
Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation (PubMed:32971525).  Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (PubMed:32971525).  In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (PubMed:32971525).  Acts as a restriction factor against some viruses: restricts viral replication by binding to mRNA viruses and mediating their degradation via its ribonuclease activity (By similarity).  Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (PubMed:17592138).
What are the official names of this protein?
NEDD4-binding protein 1, N4BP1.
What is the protein family that this protein belongs to?
Belongs to the N4BP1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus. Nucleus, PML body. Note=Primarily localizes to the nucleolus (PubMed:20233849). Also localizes to the PML nuclear bodies, when desumoylated (PubMed:20233849).
Protein: AROC_ECO81
Sequence: MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLEIKDWSQVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRQRAQNADVKTDIPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: ARNT_ECOUT
Sequence: MKSVRYLIGLFAFIACYYLLPISTRLLWQPDETRYAEISREMLASGDWIVPHLLGLRYFEKPIAGYWINSIGQWLFGANNFGVRAGVIFATLLTAALVTWFTLRLWRNKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWLAMQAQTWKGKSAGFLLLGITCGMGVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYGWLAVISCVLTVLPWGLAIAQREPDFWHYFFWVEHIQRFALDDAQHRAPFWYYLPVIIAGSLPWLGLLPGALYAGWKNRKHSATVYLLSWTIMPLLFFSVAKGKLPTYILSCFAPLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGIIATFVVSPWGPMNTPVWQTFESYKVFCAWSIFSLWAFFGWYTLTNVEKTWPFAALCPLGLALLVGFSIPDRVMEGKHPQFFVEMTQESLQPSRYILTDSVGVAAGLAWSLQRDDIIMYRQTGELKYGLNYPDAKGRFVSGDEFANWLNQHRQEGIITLVLSVDRDEDINSLAIPPADVIDRQERLVLIQYRPK
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: POXJ_PENOX
Sequence: MVDNQGPLAKDVSLANPPSDSISELSWSPVANHLAMSSWDQTVRIYDVSQSGNGEGQALFNFPAPVLSCTFSPDGAKVLGGATDGSARLMDLVAGKEAQQVAAHDAPVRCVRFFGNPGVRDPIAVTGSWDQTVKYWDLRQDRPLATLQCQERVYAMDLCQNLLVVATAGRLVHVVQLSNADQIYKTVTSPLKHQTRTVTCIPDASGFAIGSTEGRTGFHYVDESKSSLNFTFRCHREMAASKNTQNVYAVNDVSFHPKYYTFSTAGADGTFAFWDKDAHHRLKSFPSVGAPITSTGFNHDGTIFAYAVSYDWSKGFRYNTPEHPTRVVCHPVDDVDCRPKNPVKR
What is the function of this protein?
WD40 repeat protein; part of the gene cluster that mediates the biosynthesis of oxaleimides, cytotoxic compounds containing an unusual disubstituted succinimide moiety (PubMed:28365998).  The first step of the pathway is provided by the HR-PKS poxF that serves in a new mode of collaborative biosynthesis with the PKS-NRPS poxE, by providing the olefin containing amino acid substrate via the synthesis of an ACP-bound dec-4-enoate (PubMed:28365998).  The cytochrome P450 monooxygenase poxM-catalyzed oxidation at the alpha-position creates the enzyme-bound 2-hydroxydec-4-enoyl-ACP thioester, which may be prone to spontaneous hydrolysis to yield 2-hydroxydec-4-enoic acid due to increased electrophilicity of the carbonyl (PubMed:28365998).  2-hydroxydec-4-enoic acid can then be further oxidized by poxM to yield the alpha-ketoacid 2-oxodec-4-enoicacid, which is reductively aminated by the aminotransferase poxL to yield (S,E)-2-aminodec-4-enoic acid (PubMed:28365998).  The Hybrid PKS-NRPS synthetase poxE then performs condensation between the octaketide product of its PKS modules and the amino group of (S,E)-2-aminodec-4-enoic acid which is activated and incorporated by the adenylation domain (PubMed:28365998).  The resulting aminoacyl product can be cyclized by the Diels-Alderase PoxQ and reductively released by the reductive (R) domain of poxE to yield an aldehyde intermediate (PubMed:28365998) (Probable).  The released aldehyde is then substrate for a Knoevenagel condensation by the hydrolyase poxO followed by an oxidation at the 5-position of the pyrrolidone ring (PubMed:28365998).  The presence of the olefin from the amino acid building block allows for migration of the substituted allyl group to occur (PubMed:28365998).  This allylic transposition reaction takes place in a conjugate addition, semipinacol-like fashion to yield a succinimide intermediate (PubMed:28365998).  Iterative two-electron oxidations of the C7 methyl of the succinimide intermediate to the carboxylic acid can be catalyzed by one of two remaining cytochrome P450 monooxygenasess poxC or poxD to yield oxaleimide A (PubMed:28365998).  Subsequent oxidation yields the maleimide scaffold oxaleimide I (PubMed:28365998).  Both oxaleimide A and oxaleimide I can undergo oxidative modifications in the decalin ring to yield the series of products oxaleimides B to H (PubMed:28365998).
What are the official names of this protein?
WD40 repeat protein poxJ, Oxaleimides biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the WD repeat rae1 family.
Protein: MTNK_BACP2
Sequence: MVTLTASYEELTESSAVALAIRLGLIQESSHLTCTEIGDGNLNYVFHIFDHKQEKGLIIKQALPYAKVVGESWPLTLDRARIESAALIKQSEYTPHLVPAVYYSDTALAVTAMEDLSHLEIVRKGLIAGKQYPHLSDHVGEFLGKTLFYTSDFATNPKIKKQFVKQFTNPDLCDITEKLVFTDPFFDSSTNDFEEELREAAEALWADLEVQAKAAELKRIFLTSAETLVHGDLHTGSIFASETETKIIDPEFAFYGPFGFDIGHFIANLFLNALSRENEHDQQHLFDHVVNVWATFKEVFAKAWKEDSIEAFSVSDSFLETTFDRILKEATGFAGCELVRRTIGLAHAADLDAIPSPSKRIQQKKTALTLGKTFIKQYHAVETASDLVALFQQSVKE
What is the function of this protein?
Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
What are the official names of this protein?
Methylthioribose kinase, MTR kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: DF237_ARATH
Sequence: MRHATSPIVFCFLIFLVMNHVKGQAKKKRCPIGLHTYGKCGTDRAKFCFSEIESKLSFSKQVLNTISSCRCDDDRQGNKDLYWCQCDRREGRPCPAN
What are the official names of this protein?
Putative defensin-like protein 237, Putative S locus cysteine-rich-like protein 21, Protein SCRL21, SCR-like protein 21.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: PETN_MESVI
Sequence: MDIISLGWVFLMVFFSFSLSLVVWARNGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DPOL_HHV8P
Sequence: MDFFNPFIDPTRGGPRNTVRQPTPSQSPTVPSETRVCRLIPACFQTPGRPGVVAVDTTFPPTYFQGPKRGEVFAGETGSIWKTRRGQARNAPMSHLIFHVYDIVETTYTADRCEDVPFSFQTDIIPSGTVLKLLGRTLDGASVCVNVFRQRCYFYTLAPQGVNLTHVLQQALQAGFGRASCGFSTEPVRKKILRAYDTQQYAVQKITLSSSPMMRTLSDRLTTCGCEVFESNVDAIRRFVLDHGFSTFGWYECSNPAPRTQARDSWTELEFDCSWEDLKFIPERTEWPPYTILSFDIECMGEKGFPNATQDEDMIIQISCVLHTVGNDKPYTRMLLGLGTCDPLPGVEVFEFPSEYDMLAAFLSMLRDYNVEFITGYNIANFDLPYIIARATQVYDFKLQDFTKIKTGSVFEVHQPRGGSDGGNFMRSQSKVKISGIVPIDMYQVCREKLSLSDYKLDTVAKQCLGRQKDDISYKDIPPLFKSGPDGRAKVGNYCVIDSVLVMDLLLRFQTHVEISEIAKLAKIPTRRVLTDGQQIRVFSCLLEAAATEGYILPVPKGDAVSGYQGATVISPSPGFYDDPVLVVDFASLYPSIIQAHNLCYSTLIPGDSLHLHPHLSPDDYETFVLSGGPVHFVKKHKRESLLAKLLTVWLAKRKEIRKTLASCTDPALKTILDKQQLAIKVTCNAVYGFTGVASGILPCLNIAETVTLQGRKMLERSQAFVEAISPERLAGLLRRPVDVSPDARFKVIYGDTDSLFICCMGFNMDSVSDFAEELASITTNTLFRSPIKLEAEKIFKCLLLLTKKRYVGVLSDDKVLMKGVDLIRKTACRFVQEKSSQVLDLILREPSVKAAAKLISGQATDWVYREGLPEGFVKIIQVLNASHRELCERSVPVDKLTFTTELSRPLADYKTQNLPHLTVYQKLQARQEELPQIHDRIPYVFVDAPGSLRSELAEHPEYVKQHGLRVAVDLYFDKLVHAVANIIQCLFQNNTSATVAILYNFLDIPVTFPTP
What is the function of this protein?
Replicates viral genomic DNA.  The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein.  Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction.  Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).
What are the official names of this protein?
DNA polymerase catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
What are the subcellular locations of this protein?
Host nucleus. Note=The protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs.
Protein: MSHB1_FRAAA
Sequence: MHAHPDDEVIATGATMAHYAADRDTRVVLVTCTLGEMGEVLIPELINLRADHADQLGGYRIGELERACAALGVTDHRFLGGAGRWRDSGMMSSPSNADPRSFWRADLTAASEALVRIVREVRPQVMVTYDAIGDYGHPDHIRAHDVTVRAFDDAADPDFAPQAGEPWQVSKLYETALSRAAVDAAVDQLWRSDLAKTAPEGISMPSDMLLSVPDAKVTTRIEAPDFFAAKVEAMRAHRTQMTVDGFFFALVNGDGQAARATEHYVLARGTPGPPAASGKEDDLFAGLVP
What is the function of this protein?
Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
What are the official names of this protein?
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase 1, GlcNAc-Ins deacetylase 1, N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase 1.
What is the protein family that this protein belongs to?
Belongs to the MshB deacetylase family.
Protein: DISA_BEUC1
Sequence: MSELVADPTGRAVLRAVAPGTELRDGLERILRGRTGALIVLGYDEVVEEMCSGGFVLDVAFSATRLRELAKMDGAIVLDRGATRVLRAAVQLLPDAAIETGESGTRHRTAERAAKQTGFPVISVSQSMRIVAIYSDGRRWVLEDSDAILSRANQALATLERYKSRLDEVSGTLSALEIEDLVTVRDVASVVQRLEMVRRISVEIAGYVDELGTDGRLLSLQLDELIGNVGPERELVVSDYVDARRAAALDDVLAGLARLDSTDLIDLVKIAQVRGLGGPGGDALDSAVGPRGHRMLSKIPRLPSPVIGAMVDHFGTLQKMLSASVEDLQLVDGVGALRARSVREGLSRLAESSLLERFV
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: UBIA_BLOFL
Sequence: MYKRCIGFIKLMRVHQPVGFFLLLWPTLWALWITNRGIPDFIVLSLFIVGVMCMRSAGCVINDYIDYDIDMCVQRTIRRPIVIGSVKKQEALWVFFILILIALIVVCVFNNIIAVFLSLIVLGLSIIYPYLKRYIYLPQLVLGIIFSWSILIVYTVMNCAVNKTTWLLFLANTIWVVLYDTEYAMVDRDDDKCIGIKSSALLFGKIDKIVIGILQLLTVFILYIIGIVEQLPIIFYLFSIVGASILFIWQQVLIFNRNREKCLWAFLSNSYVGMLIFVGIVLSF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRPA_YERPP
Sequence: MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLADGPTIQNAALRAFAAGVTPGICFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAEVGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADDDLLREIASHGRGYTYLLSRAGVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKIIEKNVAQPVEMLVQLTRFVTEMKAATRS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: DNAB_NOSS1
Sequence: MAEELSFQGDGSNRLPPQNIEAEEAILGGILLDPEAIGRVSEVLITEAFYISAHRDIYQAALRLHAQGKPTDLLSVTSWLTDNELLTRIGGRNKLATLVDRTVSAVNIDALAGLVMEKYLRRQLIKAGNEIVHLGYETEKELPIVLDQAEQKVFGVTQERPQSGLVHIADTLINNFQEIEERNQGIALPGIPCGFYDLDAMTSGFQRSDLIIVAGRPSMGKTAFCLNLANNIAATMKLPVAVFSLEMSKEQLVQRLLASEAQIESGYLRSGRLSQTQWEPLSRAISMLSEMPIFIDDTPNITVTQMRSQARRLQAEQGVELGLIVIDYLQLMEGGGDNRVQELSKITRSLKGLARELSVPVIALSQLSRGVEARTNKRPMLSDLRESGCLTGDSLVTLAPGGLQIPIRELVGKSGFAIWALNQATLKLEKAIVSNAFSTGVKPVFTLTTRKGCKIRATANHKFLTIHGWRRLDELSIRQHLCLPRHIPSFDKQTMTYAEVALLGHLIGDGCTLPRHAIQYTTREIDLAENVFFLAKEVFGDAITPRISPERSWYQVYLSATQRLTRNLRNPVAKWLDSLGVFGLRSYEKFVPQELFSQPIELISCFLRHLWSTDGSIKLVGGKKPRPIAYYATSSYRLAVDVQTLLLKLGINATLKLVPQVGKGRNQYHVKITGKPDLDLFIKKVGAVGEYKLNSLQQIFEYLENCIHNTNRDIIPKDVWKKIVVPAMQSVQLTTRELHSNIGTSYCGLALYKANLSRERALKVAEVVQSSELLTLAKSDVYWDEIVSIEYSGEEEVFDLTVPGLHNFIANNIVVHNSIEQDADLVIMLYRDDYYNSDTPDRGLAEVIVAKHRNGPTGTVKLLFDPQFTKFKNLARSGY
What is the function of this protein?
The intein is an endonuclease.
What are the official names of this protein?
Replicative DNA helicase.
What is the protein family that this protein belongs to?
Belongs to the helicase family. DnaB subfamily.
Protein: RLMH_SHIF8
Sequence: MKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_BACAC
Sequence: MHYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLDMKEDDVLGFAKALVNAKRDLAYCSVCGHITDRDPCYICNDSHRDQSVVCVVQEPKDVIAMEKMKEYQGVYHVLRGAISPMGGIGPEDINIPQLLKRLHDETVQEVILATNPNIEGEATAMYISRLLKPTGIKVTRIAHGLPVGGDLEYADEVTLSKALEGRREV
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: CSPLC_RICCO
Sequence: MALVNAEKPEVGSSPSSLGPRNKSWVLLMLRFVAFLATAAATIVMAANRETKTFVVATIGSTPIKATVTAKFQHTPAFVFFVIANGMGSIHNLVMIAGDTFVRKFDYKGLRWVTVAILDMLTAALISGGVNAAVFMAELGKNGNSHAKWNKICDRFGSFCDHGGAAIIASFIGLLLMLVISIISIIKLLKPKSPLVDSHVLAP
What are the official names of this protein?
CASP-like protein 1B1, RcCASPL1B1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.