PharMolix/UniProtQA huggingface dataset:
Protein: PSN2_CHICK
Sequence: MITFMNNSDSEDEPCNERTSLMSAESPPVPSYQDGLQASETREAQTHRKRQTGSSRSPNNVADEDASDSDVRVRESALENEEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFSEDTPSVGQRLLNSVLNTIIMISVIVVMTVFLVVLYKYRCYKFIHGWLILSSFMLLFLFTYIYLGEVLKTYNVAMDYPTVILIIWNFGAVGMIRIHWKGPLQLQQAYLIMISALMVLVFIKYLPEWSAWVILGAISIYDLIAVLCPKGPLRMLXETAQERNQPIFPALIYSSAMIWTVGMAKPDTAAKGQSQQAWDAEDERENHSSTSHSDSQILDTRSPAPSHPITLEEMEEEERGVKLGLGDFIFYSVLVGKAAATPSGDWNTTLAXXVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRTDPLEISV
What is the function of this protein?
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).  Requires the other members of the gamma-secretase complex to have a protease activity.  May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.  May function in the cytoplasmic partitioning of proteins.  The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis.  Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
What are the official names of this protein?
Presenilin-2, PS-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: TCYJ_ECOL6
Sequence: MKLAHLGRQALMGVMAVALVAGMSVKSFADEGLLNKVKERGTLLVGLEGTYPPFSFQGDDGKLTGFEVEFAQQLAKHLGVEASLKPTKWDGMLASLDSKRIDVVINQVTISDERKKKYDFSTPYTISGIQALVKKGNEGTIKTADDLKGKKVGVGLGTNYEEWLRQNVQGVDVRTYDDDPTKYQDLRVGRIDAILVDRLAALDLVKKTNDTLAVTGEAFSRQESGVALRKGNEDLLKAVNDAIAEMQKDGTLQALSEKWFGADVTK
What is the function of this protein?
Part of the ABC transporter complex TcyJLN involved in L-cystine import.  Binds cystine.
What are the official names of this protein?
L-cystine-binding protein TcyJ, CBP, Protein FliY.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 3 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TYRB_KLEPN
Sequence: MFQKVDAYAGDPILSLMERFKEDPRSDKVNLSIGLYYNDDGIIPQLQAVAEAEARLNAEPHGASLYLPMEGFSGYRQAIAPLLFGAEHTALKQNRIASIQTVGGSGALKVGADFLKRYFPESHVWVSDPTWENHIAIFEGAGFEVSTYPWFDKATNGVRFENLLAMLQTLPARDIVLLHPCCHNPTGADLTPAQWDRVVEVLKARQLIPFLDIAYQGFGGGLEEDAYAIRAIASAGMPMLVSNSFSKIFSLYGERVGGLSVVCEDSETAGRVLGQLKATVRRNYSSPPSFGAQVVATVLNDAALKATWQAEVDAMRAHILTMRQALVDALQQVAPGSKVDYLLKQRGMFSYTGFSAAQVDRLRDEFGVYLIASGRMRVAGLNSRNVQQVAKAFVAVM
What is the function of this protein?
catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) or glutamate as the amino donors.  Histidine, leucine, asparagine, or arginine are also functional amino donors but to a lesser extent.  Can also use alpha-ketoglutarate, oxaloacetate and pyruvate as the amino acceptors.
What are the official names of this protein?
Tyrosine aminotransferase, TyrAT, Aromatic-amino-acid transaminase, Aspartate aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: AROH_ENTAG
Sequence: MNKTDELRTARIGSLITPPSLAAEHPVSPAIADNVTAARKRIACILTGEDHRLLVVIGPCSLHDPKAALEYAERLNALRRRYEDRLEIVMRAYFEKPRTVVGWKGLISDPDLDGSYDVNRGIGIARQLLIDINALGLPTATEFLDMVIGQFIADLISWGAIGARTTESQIHREMASALSCPVGFKNGTDGNVQIAVDAIRAARASHMFLSPDKLGQMTIYQTSGNPHGHVILRGGKQPNYHASDVAAAAESLSAFNLPQQLVIDFSHGNCLKQHRRQMDVAAEVAEQIKAGSQAVAGVMIESFLEEGNQKVVSGEPLVYGKSITDPCLGWQESEKVLALLAEAVSHRL
What is the function of this protein?
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
What are the official names of this protein?
Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, DAHP synthase, Phospho-2-keto-3-deoxyheptonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class-I DAHP synthase family.
Protein: RHAA_LISMO
Sequence: MGQETEINKRYQVAKERYQAIGVDTEKALKTLKDIKISMHCWQGDDVKGFLNPDGELTGGIMATGNYPGAAHTPKQLRQDLEKAYSLIPGKHKLNLHAIYVDTDEKVDLNEIEPKHFTPWVEWAKEQGLGLDFNPTFFSHPMFKDNYTLASPDKEVRDFWIEHGKRSRKISEYFGKELGQTSINNFWVPDGIKDCPIDRYTPRKRLMEALDEVFAEKLDEKYTQEAVESKLFGLGAEAYTVGSHEFYMGYGITRDKLICLDAGHFHPTEVISNKLSSLALFSKGVMLHVSRPVRWDSDHVVIMDDELIEIGRELVRNDLLGITNIGLDFFDATINRIAAWVVGTRNTQKSLLKALLEPTADLKKMELENDFTSRMAITEELKDFPFGDVWNYFCEINGVPVGLDWLKEVKAYEEDVLLKR
What is the function of this protein?
Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
What are the official names of this protein?
L-rhamnose isomerase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_ECOSE
Sequence: MAKEFGRPQRVAQEMQKEIALILQREIKDPRLGMMTTVSGVEMSRDLAYAKVYVTFLNDKDEDAVKAGIKALQEASGFIRSLLGKAMRLRIVPELTFFYDNSLVEGMRMSNLVTSVVKHDEERRVNPDDSKED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCTR3_RAT
Sequence: MAKVLLIVFIMVYAGSCAIWVSQPPEIRAQEGTTASLPCSFNASRGKAAIGSATWYQDKVAPGMELSNVTPGFRGRVASFSASQFIRGHKAGLLIQDIQSHDARIYVCRVEVLGLGVGTGNGTRLVVEKEPPQQASNAEPERAAYTSLLLRAGVYALSFLSVATGSVIYYQGKCLCHVGNTATPPTASEERF
What is the function of this protein?
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1.  Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands.  It controls, for instance, NK cells cytotoxicity against tumor cells.  Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation.
What are the official names of this protein?
Natural cytotoxicity triggering receptor 3, Natural killer cell p30-related protein, NK-p30, NKp30.
What is the protein family that this protein belongs to?
Belongs to the natural cytotoxicity receptor (NCR) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RS6_GEOUR
Sequence: MRMYETIFIVQPDLGEEEMKGISTKVQDVIASMKGDFKRLEDWGPRKLAYPINKFARGRYYYLRFDGDSALIAELERRLRLDDKVIRYQSVKLEKEVALAAAIPTKVAEEEAVESAEETKVETTTVEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RNFG_SHELP
Sequence: MKRSIVKNASLLGLFALLCTALVALVNQFTFERIKQQQDLELMRTLHQIIPDEMHDNALIEHCILIQDADVLGIDEPLPAYIASQGGEPVAIAMETVAPDGYNGQIKLIVAIDAKGEVLGVRTLNHNETPGLGDKIDLRKSSWVLGFKGQSIQGEQDKRWAVKKDGGQFDQFTGATITPRAYVGAVKRTLAYFNANQQTLLNRPANCEVQYE
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit G, Rnf electron transport complex subunit G.
What is the protein family that this protein belongs to?
Belongs to the RnfG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ARGC_LACE2
Sequence: MIKVGIIGATGYAGNELVRLLLGHKDAEIVWLGSRSYIDQNYSDVYRNMFKLVDAKCMDDNMEQLANEVDVIFTATPQGLCASLVNDEILSKTKIIDLSADFRLKDVNVYEQWYKLEHKAPQYIDEAVYGLCEINRDKVSKDTRIIANPGCYTTTSILTLYPMVKEGIINPDTIIIDAKSGTSGAGRGAKVANLFCEVNESMKAYGVGTHRHTPEIEEQLGYACGRDDLKLIFTPHLVPMNRGILVTAYANLAKDVTYEDVKAAYDKYYDKEYFVRVLPKDVCPETRWVEGSNFVDIGFKIEPRTNRLIMMGALDNLVKGAAGQAVQNMNLLFGLPENEGLQIAPMFP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBB_CANAX
Sequence: MREIIHLSTGQCGNQIGAAFWETICGEHGLDNNGTYVGNNELQKSKLDVYFNEATSGKYVPRAVLVDLEPGTIDNVKTSQIGNLFRPDNFIFGQSSAGNVWAKGHYTEGAELVDSVLDVVRREAEGCDSLQGFQITHSLGGGTGSGMGTLLISKIREEFPDTMMATFSVVPSPKVSDTVIEPYNATLSVHQLVENSDETFCIDNEALYNICQNTLKLPQPSYAELNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNLVPFPRLHFFMVGYAPLTSMGSKSFRSVTVPELTQQMFDAKNMMAASDPRNGRYLTVAAFFRGKVSVKEVDDEMHKIQTRNSSYFVDWIPNNVQTAVCSVPPKDLDMSATFIGNSTSIQELFKRVGDQFSAMFRRKAFLHWYTSEGMDEMEFTEAESNMNDLVSEYQQYQEASIDEEELEYADEIPLEDAAME
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PG082_VARV
Sequence: MNNFVKQVASKSLKPTKKLSPSDEVISLNECIISFNLDNFYYCNDGLFTKPINTPEDVLKSLLIMESFAYEKMIIKGLIKILISRAYINDIYFTPFGWLTGIDDDPETHVVIKIIFNSSLISIKSQVIEYLKPYNVNNLSVLTTEKELSINTFNVPDSIPMSIISFFPFDTDFILVILFFGVYNDSYCGISYISPKERLPYIIEILKPLMSEINMLSDEIGRTSSIRIFNSTSVKKFPTNTLTSICEIVYSFDESSFPTPKTFTPLNASPYIPKKIVSLLDLPSNVEIKAISRGGVDFITHINNKRLNTILVIAKDNFLKNSTFSGTFIKENIIWKGIYTYRIIKSSFPVPTIKSVTNKKKICKKHCFVNSQYTTRTLSHIL
What is the function of this protein?
Binds to the hairpin form of the viral telomeric sequence.  Might direct genome encapsidation into the virus particle.
What are the official names of this protein?
Telomere-binding protein OPG082, Telomere-binding protein I6.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG082 family.
Protein: ULAR_ECOL6
Sequence: MTEAQRHQILLEMLAQLGFVTVEKVVERLGISPATARRDINKLDESGKLKKVRNGAEAITQQRPRWTPMNLHQAQNHDEKVRIAKAASQLVNPGESVVINCGSTAFLLGREMCGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQSITLSPQGSENSLYAGHWMFTSGKGLTAEGLYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNANPEILQQLEAQGVSILRV
What is the function of this protein?
Represses ulaG and the ulaABCDEF operon.
What are the official names of this protein?
HTH-type transcriptional regulator UlaR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_STRA5
Sequence: MQYSEIMIRYGELSTKKKNRMRFINKLKNNMEHVLSIYPDVSVKTDRDRGHVYLNGTDYHEVAESLKEIFGIQAFSPSFKVEKNVDTLVKAVQEIMTSVYKDGMTFKITAKRSDHSFELDSRALNHTLGDAVFSVLPNIKAQMKQPDINLKVEIRDEAAYISYEDIRGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGVDIEAVHFASPPYTSPGALKKAHDLTRKLTKFGGNIQFIEVPFTEIQEEIKAKAPEAYLMTLTRRFMMRITDRIREDRNGLVIINGESLGQVASQTLESMQAINAVTATPIIRPVVTMDKLEIIDIAQKIDTFDISIQPFEDCCTIFAPDRPKTNPKIKNTEQYEKRMDVEGLVERAVAGIMVTTIQPQADSDDVDDLIDDLL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4CC_SINFN
Sequence: MKFLERSLEVDHIHEPELEFAFGQKSAHPKDGLHLYGPHLKGKKAKEIRVGVIGTSEGIGHFRTWSRELQSIVKVPPPGKGEKANRLHLANFPGLEETFGISYDPDELSALSIPLADIDRATRVTNQHEAVDKVAKLYIERVNKHLHNEERAVDIWVLVLPEIVYERCRPNSKRTGLPTEKGDFAKKQKKRESLPLLAGIIDQSGETIFDDVPDFHRRIKADFLNIAPTQLIRETTLAPGAFLNTAGYPTRKTQDRATVAWNLGTGLYYKTQPRPPWRLSTIRPGVCYLGMVYKSLPNDPDGHACCAAQMFLNEGDGVVFRGANGPWKTGDYDYHLKAPAAKDLLKLVLDSYVDTHGEAPKELFIHGQTYFNDEEWAAFADAAPKGTNVVGVRIRPTGGEMKLFRDGDYPVLRGTALILDAQTAYIWTTGYVPQLDTYIGPETPNPLHVTVTRSKDAKPEIRDVLSDIMGLTKINYNSCNFNDGLPVTVRFARMVGDVLTMGSAIKGEKKQPFKFYI
What are the official names of this protein?
Uncharacterized protein y4cC.
Protein: ISTB_BACFG
Sequence: MKSSMAMIKHKKELVEYARHLKLPNLAEHVGVILHEAQEKQLTYSEFLANCLAREIQGRERKSYLTRLKLSGLPAKYDLDLYDYDRAEGMDNRRLRELRELVWVNQAYNLLLVGPSGTGKTFIAAGLVYEAVKAGYEAYLMTLEELLTCLKTKEVSAHAMKTYKRIMKARLLAIDDATLFPLKREEAVLLFKLVNDFQERTSLIITANKALTRWLETLEDEAVTAALLDRLLYCCEIIRLGGTSYRMQNRKTIFSNQNTDIGT
What are the official names of this protein?
Insertion sequence IS21-like putative ATP-binding protein.
What is the protein family that this protein belongs to?
Belongs to the IS21/IS1162 putative ATP-binding protein family.
Protein: NUDJ_ECO57
Sequence: MFKPHVTVACVVHAEGKFLVVEETINGKALWNQPAGHLEADETLVEAAARELWEETGISAQPQHFIRMHQWIAPDKTPFLRFLFAIELEQICPTQPHDSDIDCCRWVSAEEILQASNLRSPLVAESIRCYQSGQRYPLEMIGDFNWPFTKGVI
What are the official names of this protein?
Phosphatase NudJ.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudJ subfamily.
Protein: YUSU_BACSU
Sequence: MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKEEVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ
What are the official names of this protein?
Uncharacterized protein YusU.
Protein: SUV3_CAEBR
Sequence: MQRATGVLRILGSFSQRCSPSSSATPSRFQTMNSRRKRNSIRKAAAIEDLVEPRKVKHVTQAAAGMEEWIGSLNNAAIHMALDEFMRRPMVRQLAKENGINDKLFIRAFKSFREYCTPEDLSSVDPGLLILMSDISKGGKDCEMLYPFFLDHSKQVFPHLEAMDDLRIISDLTRPHNWYPEARSIIRKIFFHAGPTNSGKTYHALKRFGEAKSAVFCGPLKLLATEVFNRTNALGIPCDLVTGEERRFAKDNHHPSQHLSSTVEMLSTQMRVEVVVIDEIQMLRDEQRGWAWTRALLGAAADEIHLCGEPAAINIVKKLLEPIGETVEVRYYDRKSPLTIADRAIESYSNIEPGDCIVCFSKRAVFFNSKKLEENGIKPAVIYGDLPPGTKLAQAAKFNDPDDECNVLVATDAIGMGLNLNIRRVIFNSCTRQTELLPTYAALQIAGRAGRFGTAYANGVATTMRKEDLGTLKTILAEKVEPITNVGIAPTYDQIETFSFHLPQASFVRLLDLFVSVCSVSDHFFICTVYDMRELAVLIDQVPLPLKVRYTFCTSPLNTDDKRTAAVFVKMARRFATGQALTYEWLMDMLEWPPKPASTLSELSLLEQNYEVLDQYMWLSMRFPDMLPDEPRVRDASKILDKMIQDGVEGFMSLLAVGPGDNSDSREKRLSRPSEEKLAKSASEKPTRKSSILEALLKRTDISEEDLDQLREELNKKKKKP
What is the function of this protein?
ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction.
What are the official names of this protein?
ATP-dependent RNA helicase SUV3 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus.
Protein: RS21_STRP6
Sequence: MSKTVVRKNESLDDALRRFKRSVTKAGTLQESRKREFYEKPSVKRKRKSEAARKRKKF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: Y52A_METJA
Sequence: MMDIVEIIIGFIALLMTARIFLERSRARKLLYLCCLSFCISALIALYVDSPMGGIVAITYFICSTISSNAIAYTIEQTKHIE
What are the official names of this protein?
Uncharacterized protein MJ0526.1.
What is the protein family that this protein belongs to?
To M.thermoautotrophicum MTH386.
Protein: CX3C1_BOVIN
Sequence: MHTTLPESTSENFEYYDLAEACDMGDIVALGTVFVVILYSLVFAFGLVGNLLVVFALINSQRSKSITDIYLLNLALSDLLFVATLPFWTHYVINEQGLHHATCKLITAFFFIGFFGGIFFITVISVDRFLAIVLAANSMSNRTVQHGVTTSLGVWAAAILVATPQFMFTREKENECFGDYPEILQEIWPVILNTEINFLGFLLPLLIMSYCYFRIMQTLFSCKNHKKAKAIRLIFLVVVVFFLFWTPYNVMIFLQTLNLYDFFPKCDVKRDLKLAISVTETIAFSHCCLNPLIYAFAGEKFRRYLYRLYRKCLAVLCCHPDHLSFSSSLSESQRSRRESVLSSNFTHYTSDGDASILL
What is the function of this protein?
Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis.  CX3CR1-CX3CL1 signaling mediates cell migratory functions.  Responsible for the recruitment of natural killer (NK) cells to inflamed tissues.  Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival.  Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung.  Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells.  Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis.  Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation.  Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli.  Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development.  Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development.  Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi.  Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria.  Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C. albicans or C. auris infection (By similarity).  Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity).
What are the official names of this protein?
CX3C chemokine receptor 1, C-X3-C CKR-1, CX3CR1, Fractalkine receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EZRA_GEOTN
Sequence: MEIVWIVLLLGAGVIIYNHMYRKKMYREIDRLEAWKIELMNRPVPDELAKVKQLNMTGETEQLFERWRQQWDEIVAVKLPNVEEQLFDTETFLDKYRYRQARKLIGQIEDGLRRLEEEVHQIIDEVNELIGSEEQSRTEIEELRAVHREAKKTLLAYRYTFGAAADLLDVRLTEAEKQFESFAKLTEAGNYLAARGVVQELKQELDSLATMMEEIPALLSECQTSLPAQLAELADGYREMEQSGYILDHLHIERTLAEKQEKIGQCLAMIGELRIEEAKQTVAELKEEIDTLYDLLEKEVLANQYVQTEMPRIGGMLTELAAEAKETSAEAMFVQQSYHLPPSDLEKYRSIEKQMHQLQKRFLLIEDRVAEAKTAYSLLREELEQLVGQIDMMKEEHEQFRLMLQALRKDELIAREKLDDMRKKLSESLRLVQKSRLPGLPEPYALELTEAKNSLQNVAARLEEKPLDMPAVDRALEEAKVSVERLYERTVEMIEQASLAERAIQYGNRYRRRYPAVHKGLEEAEFLFRHYDYEEALRQAVATIESVEPGAFDRVQKLWQADNEDEQ
What is the function of this protein?
Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation.  Inhibits FtsZ ring formation at polar sites.  Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
What are the official names of this protein?
Septation ring formation regulator EzrA.
What is the protein family that this protein belongs to?
Belongs to the EzrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Colocalized with FtsZ to the nascent septal site.
Protein: RS8_SULIM
Sequence: MVFVNPLANALTSIYNNEMRRNKQAIIMPASKLVINVLRVMQKEGYVGEFEYIDDGRWGKITVQLLGRVNKCGPITPRYPLSYRQMIALPDYIRRYLPSKEIGIIIVSTSKGVMSHKEAARMRLGGVALGYVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SPCS3_BOVIN
Sequence: MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY
What is the function of this protein?
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).
What are the official names of this protein?
Signal peptidase complex subunit 3, Microsomal signal peptidase 22/23 kDa subunit, SPC22/23, SPase 22/23 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the SPCS3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: DNAA_BURTA
Sequence: MNDFWQHCSALLERELTPQQYVTWIKPLAPVAFDAAANTLSIAAPNRFKLDWVKSQFSGRISDLARDFWNAPIEVQFVLDPKVGQRSAAGAAPLAPRAPLPAANPAPVTAGPAPSGAADANAPAPAGMNAATAAAVAAVAAAQAAQAAQANAAALNADEAADLDLPSLTAHEAAAGRRTWRPGAASANSEAADSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIHAIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQEEFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMRKAQSEGVSLSEDVAFFVAKHLRSNVRELEGALRKILAYSKFHGREITIELTKEALKDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIADERGKDAQLNHELHVLEQTLKG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPPA_PYRCJ
Sequence: MPIPRLMCTQHPDTTVKITAAEEVDEAIVAFTAYGCDEVMVDYEGKATPYSQPKEVVMKAAKSELPLGEKFVITVRLPNPRLEEFDRAMLALEAAVVANYFSVKYMGVRAVKWVVLPMVEDVETMSLVRRMLKRKVEDYKAEAKVDVGNIEVIPLFEDAFVQLKAKALLGEVFKGEEVREVRLFLGKSDSAVKHGHLASALAIAYTLSRLGDVESELGLRIRPILGMGSPPFRGGLNNPRLAPMEVVQYAGYYTATIQSAVRYDVALEEFLKVREAILNGCCAPRQRAPDEVLHIVQEASARYRALVMKYADKVIEVARLVPSTRDRVSWTAYGRTLTGGERVVNMPRAIVYTSAWYATGLPPTLLDAPYLLELAKSDKLDLVLKVLPTYLKELEYDLEFFDRATAEKYLDGEIVKAVVELADYLGLEARPNPAYATLLRMPRNEANIIALGKYRKFLG
What is the function of this protein?
Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 2 family.