PharMolix/UniProtQA huggingface dataset:
Protein: TPPP_RAT
Sequence: MADSKAKPTKAANKTPPKSPGDPAKAAKRLSLESEGANEGAAAAPELSALEEAFRRFAVHGDTRATGKEMHGKNWSKLCKDCHVIDGKNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGRAPVISGVTKAVSSPTVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPGYKHAGTYDQKVQGGK
What is the function of this protein?
Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:19606501).  Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (By similarity).  Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (By similarity).  Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity).  In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (By similarity).  Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity).  Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity).  Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity).  Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity).
What are the official names of this protein?
Tubulin polymerization-promoting protein, TPPP, 25 kDa brain-specific protein, TPPP/p25, p25-alpha.
What is the protein family that this protein belongs to?
Belongs to the TPPP family.
What are the subcellular locations of this protein?
Golgi outpost. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (PubMed:31522887). Mainly localizes to the cytoskeleton. Also found in the nucleus; however, nuclear localization is unclear and requires additional evidences. Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies. During mitosis, colocalizes with LIMK2 at the mitotic spindle (By similarity).
Protein: MURG_SHEAM
Sequence: MGPQTGKRLLVMAGGTGGHVFPALAVARRLASEGWQIRWLGTADRMEARLVPQHGFDIDFIDIQGVRGNGLLRKLAAPFKVLRSVMQARKVIREFKPDVVLGMGGFASGPGGVAAKLCGIPLVLHEQNAIPGMTNKLLSRIATRVLCAFEGAFGSLGTTVGNPIREELVALGAKPRESRTEALKVLVVGGSLGAKVFNDLMPSVTARIAQLQPVTVWHQTGKNNLSTVQAEYQLQGQDGGVKIAEFIDDMEAAYRWADVVLCRAGALTVSELAAVGLPSILVPYPHAVDDHQTMNARVLVDAGAAFLVPQPIATTELLADKLQLLAGDRDELTRMGERARAAAVLDATERVAEVCRELAK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PURA_CLOK5
Sequence: MSAFIVLGSQWGDEGKGKMTDYLAKDVDVVVRFQGGNNAGHTVRVGDKEYKLHIIPSGILYKDKVNVIGNGVVLDPEALFQEIDYLEKAGVDIQPDNLMISDRAQLIMPYHKVLDGIKERSRGKKDIGTTGKGIGPCYTDKMERSGIRVCDLINQDVFKENLKENLKIKNDIITKVYGEEALDFDSICDQYIEYRKKLAPYVKDISVEVYNSIKNDKKVLFEGAQGTLLDIDYGTYPYVTSSSTIAGGVCIGAGIGPTLITGAIGVAKAYTTRVGKGPFPTELFDDTGDWIRKSGREYGVTTGRARRCGWLDLVILKTSSRVSGLTNFAITKIDTLGGLEKVKVCTGYKFNGKIIDYVPASLQDLAKCEPVYEEFDGWDKDIENAKTYDELPENAKIYLNKIEEFTNTKISIVSVGPGRDQTINLNNM
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUAD_BOVIN
Sequence: MAASKVKQDMPPVGGYGPIDYKRNLPRRGLSGYSMFAVGIGALLFGYWSMMKWNRERRRLQIEDFEARIALMPLLQAEKDRRVLQMLRENLEEEATVMKDVPGWKVGESVFHTTRWVTPMMGELYGLRASEEVLSATYGFIWYT
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.  Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death.  This apoptotic activity is inhibited by interaction with viral IRF1.  Prevents the transactivation of STAT3 target genes.  May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, Cell death regulatory protein GRIM-19, Complex I-B16.6, CI-B16.6, Gene associated with retinoic-interferon-induced mortality 19 protein, GRIM-19, NADH-ubiquinone oxidoreductase B16.6 subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA13 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus. Note=Localizes mainly in the mitochondrion. May be translocated into the nucleus upon IFN/RA treatment.
Protein: WEB1_ARATH
Sequence: MEDLKTVEASDNVVSDNVEKVNPELIDSTIRESNIQSATKVDNIPQSQTDTEETQQSQTDTEETQQSQTDDTTGNAKIYVDDTFSPSDAATAAVLTGKDSTSTTIVEEVMEPDEIGLPSVKITEAATGTARNGGGSPRTVSSPRFSGSPVSTGTPKNVDSHRGLIDTAAPFESVKEAVSKFGGITDWKSHRMQAVERRKLIEEELKKIHEEIPEYKTHSETAEAAKLQVLKELESTKRLIEQLKLNLDKAQTEEQQAKQDSELAKLRVEEMEQGIAEDVSVAAKAQLEVAKARHTTAITELSSVKEELETLHKEYDALVQDKDVAVKKVEEAMLASKEVEKTVEELTIELIATKESLESAHASHLEAEEQRIGAAMARDQDTHRWEKELKQAEEELQRLNQQIHSSKDLKSKLDTASALLLDLKAELVAYMESKLKQEACDSTTNTDPSTENMSHPDLHAAVASAKKELEEVNVNIEKAAAEVSCLKLASSSLQLELEKEKSTLASIKQREGMASIAVASIEAEIDRTRSEIASVQSKEKDAREKMVELPKQLQQAAEEADEAKSLAEVAREELRKAKEEAEQAKAGASTMESRLFAAQKEIEAAKASERLALAAIKALEESESTLKANDTDSPRSVTLSLEEYYELSKRAHEAEELANARVAAAVSRIEEAKETEMRSLEKLEEVNRDMDARKKALKEATEKAEKAKEGKLGVEQELRKWRAEHEQKRKAGDGVNTEKNLKESFEGGKMEQSPEAVVYASSPSESYGTEENSETNLSPQTKSRKKKKKLSFPRFFMFLSKKKSHNN
What is the function of this protein?
Required for the chloroplast avoidance response under high intensity blue light.  This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells.  Acts in association with PMI2 to maintain the velocity of chloroplast photorelocation movement via cp-actin filaments regulation.
What are the official names of this protein?
Protein WEAK CHLOROPLAST MOVEMENT UNDER BLUE LIGHT 1, Protein WEB1.
What is the protein family that this protein belongs to?
Belongs to the WEB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2750_MYCTO
Sequence: MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASVPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRASLSVALQAGLDEFGRLDIVVANAGIAMMQAGDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSAAGLVGIGSSDPGSLGYAAAKHGVVGLMRAYANHLAPQNIRVNSVHPCGVDTPMINNEFFQQWLTTADMDAPHNLGNALPVELVQPTDIANAVAWLASEEARYVTGVTLPVDAGFVNKR
What are the official names of this protein?
Uncharacterized oxidoreductase MT2820.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: SYDND_NATTJ
Sequence: MKRTHYCGELTRELVGKKVVLKGWADNRRDHGKLIFIDMRDNSGLVQVVCDFESNPEALEVADSVRSEYVLEITGTVRERSPENVNPDLKTGEIEVDCEDINVLNTSKTPPFFINENVDVDENIRLKYRYLDLRRPSMQNNIYLRHKITKLVRDFLDENGFIEVETPMLTKSTPEGARDFLVPSRLHEGSFYALPQSPQLFKQLLMASGVEKYFQIARCFRDEDLRADRQPEFSQIDIEMSFFEQEEFMKLMENMVSKLFKEVLGIELTKPFPRITYQEAMDRYGSDSPDLRYGLELHDVSDLVKDAEFKVFRETVASEGQVKGIAVPQGQEFSRKEIDDLTEFVKEFGAKGLAWMVLEEEEIKSPIAKFFSDEELDGIIDRMGANTGDLLLFVADEPEIVADSLSKLREHLANKLDLIPSNEYQLTWVIDFPLMEYDKDEGRYKALHHPFTSPYEDDLEKYENEPEKIRAKAYDLVLNGVEIGGGSMRIHQKELQEKMFEFLGIPLEEAKQKFGFLFEAFEYGTPPHGGIAFGLDRLVMLFTGSQSIRDVIAFPKTANASCLMTEAPAKVDENQLKELHLKTTK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DKSA_ECOLI
Sequence: MQEGQNRKTSSLSILAIAGVEPYQEKPGEEYMNEAQLAHFRRILEAWRNQLRDEVDRTVTHMQDEAANFPDPVDRAAQEEEFSLELRNRDRERKLIKKIEKTLKKVEDEDFGYCESCGVEIGIRRLEARPTADLCIDCKTLAEIREKQMAG
What is the function of this protein?
Transcription factor that acts by binding directly to the RNA polymerase (RNAP).  Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.  Also required for regulation of fis expression.  Binding to RNAP disrupts interaction of RNAP with DNA, inhibits formation of initiation complexes, and amplifies effects of ppGpp and the initiating NTP on rRNA transcription.  Inhibits transcript elongation, exonucleolytic RNA cleavage and pyrophosphorolysis, and increases intrinsic termination.  Also involved, with RecN, in repair of DNA double-strand breaks.  Required, probably upstream of the two-component system BarA-UvrY, for expression of CsrA-antagonistic small RNAs CsrB and CsrC (PubMed:21488981).
What are the official names of this protein?
RNA polymerase-binding transcription factor DksA, DnaK suppressor protein.
What is the protein family that this protein belongs to?
Belongs to the DksA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA1_PSEF5
Sequence: MFSRDLTIAKYDADLFAAMEQEAQRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHAGSQANAAVYLALLQGGDTILGMSLAHGGHLTHGAAVSSSGKLYNAIQYGIDANGLIDYDEVERLAVEHKPKMIVAGFSAYSQILDFPRFREIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLILARANADIEKKLNSAVFPGAQGGPLEHVIAAKAICFKEALQPEFKAYQEQVVKNAQAMAEVFIARGFDVVSGGTKNHLFLLSLIKQDISGKDADAALGKAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDAVREKVKAICKKLPVYGA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 1, SHMT 1, Serine methylase 1.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_PROMS
Sequence: MSLDTAEKQKLIENHQVHPTDTGSVEVQVAMLSKRISKLSDHLQGNIHDFASRQGLLKMIGKRKRLLSYLKDKNVQKYQELVKKIGIRG
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: DF264_ARATH
Sequence: MEKMVLRKVVLLAILLSLSCLWVAKALEGESKVSGQVRDETPHTWYCKYDDNCRENCPGCTITKCNYGVCICSNCYHQQSDLGVESHM
What are the official names of this protein?
Putative defensin-like protein 264.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: G6PI_VIBC3
Sequence: MLKNINPTQTQAWKALTAHFESAQDMDLKALFAQDSERFAKYSARFGQDILVDYSKNLVNAETMQHLFALAKETDLQSAITAMFKGEAINQTEDRAVLHTALRNRSNSPVLVNGEDVMPAVNAVLAKMKAFSERVIGGEWKGFTGKAITDVVNIGIGGSDLGPYMVTEALVPYKNHLTMHFVSNVDGTHMAETLKNVDPETTLFLVASKTFTTQETMTNAHTARDWFLKAAGDEAHVAKHFAALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIILSIGYDNFVELLAGAHEMDQHFVNTPFESNIPVILALIGIWYNNFHGAESEAILPYDQYLHRFAAYFQQGNMESNGKYVDRDGNPVTYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAVSHNLVGDHHQKLMSNFFAQTEALAFGKSAQAVQAELEKAGKSAAEIAALVPFKVFEGNRPTNSILVKQITPRTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADSAAVTSHDSSTNGLINAFKAFRA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IKZF5_XENLA
Sequence: MGEKKPETLDFVKDFQEYLTQQTHHVNMISGSVSSDKEAETLQGGTQNHDALSANSPCLALPAAATDSDQNGLDHPSVEVSLDESAGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIRIHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRKHKMLPIKGTRPSLGNKKMWGVLQKKVSSLGYTRRTLINLSPPSMVVHKADYLSDFAHEIPSIQSEAYEHLAKASHSVGLSRDPQELMVDNPLNQLSTLAGQLSSLPPDTQNPASPDTGPCPDEKPFMIQQPPPPACSSAVSTSVAQSSSPASPEGRPSHNHRNCSPMAGPSSERSGRTSTPSISNSQPSTPAPALPVQDPQLLHHCQHCDMYFADNILYTIHMGCHGFENPFQCNICGCKCKNKYDFACHFARGACCQHSSRCAFRRTDDHVTK
What is the function of this protein?
Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence.
What are the official names of this protein?
Zinc finger protein Pegasus, Ikaros family zinc finger protein 5.
What is the protein family that this protein belongs to?
Belongs to the Ikaros C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS3_GLUOX
Sequence: MGHKVNPIGLRLGVNRTWDSRWYAGQDYARLLHEDLKLRAFLRRKLSGAGVSRVVIERPAKKPRVTIYAARPGVVIGKKGQDIDALRKELSRMAKTDVALNIVEIRKPEIDATLVAENIAQQLERRVAFRRAMKRAIQSAMRLGAQGIRITCGGRLGGAEIARAEKYREGRVPLHTLRADIDYGTATAKTTYGTCGVKVWIFKGEILAHDPLAQDRRAAEQAPQR
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: ESTB_BACSU
Sequence: MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGASYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDIVAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSLNDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN
What is the function of this protein?
An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (C3-C10) with the maximum activity towards tricaprylin (C8:0); essentially inactive on C18:1 or C18:4 substrates.  Active against p-nitrophenylesters with fatty acid chain lengths from C6 to C18.
What are the official names of this protein?
Extracellular esterase EstB, Extracellular esterase LipB, Lipase B, Triacylglycerol lipase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATOB_PSEAE
Sequence: MQDVVIVAATRTAVGSFQGSLAGIPAPELGAAVIRRLLEQTGLDAGQVDEVILGQVLTAGSGQNPARQAAIKAGLPVGVPAMTLNKVCGSGLKALHLGAQAIRCGDAEVIVAGGQENMSLAPYVMPGARTGLRMGHAKLVDSMIEDGLWDAFNDYHMGITAENLAEKYGLTREEQDAFAAASQQKAIAAIEGGRFRDEITPIQVPQRKGEPLGFDTDEQPRAGTTVEALAKLKPAFRKDGSVTAGNASSLNDGAAAVLLMSAAKAKALGLPVLARIASYASAGVDPAIMGIGPVSATRRALDKAGWSLEQLDLIEANEAFAAQSLAVGRELGWDAARVNVNGGAIALGHPIGASGCRVLVTLLHEMIRRDAKKGLATLCIGGGQGVALTLARD
What are the official names of this protein?
Acetyl-CoA acetyltransferase, Acetoacetyl-CoA thiolase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNTR_ECOLI
Sequence: MYRIGELAKMAEVTPDTIRYYEKQQMMEHEVRTEGGFRLYTESDLQRLKFIRHARQLGFSLESIRELLSIRIDPEHHTCQESKGIVQERLQEVEARIAELQSMQRSLQRLNDACCGTAHSSVYCSILEALEQGASGVKSGC
What is the function of this protein?
Zinc-responsive transcriptional regulator of zntA.
What are the official names of this protein?
HTH-type transcriptional regulator ZntR, Zn(II)-responsive regulator of zntA.
Protein: MTBB1_METMA
Sequence: MATEYALRMGDGKRVFLAREKIMEEIEAGTANAADLGEIPALSADEMNKLAEILMMPGKAVSVEHGMEIPVTHDIGTIRLDGDQGNSGVGIPSSRLVGCMMHERAFGADTMELGHIDYSFKPVKPVVANECQAMEVCQQNMIIPLFYGAMPNMGLYYTPDGPFENPGDLMKAFKIQEAWDSMEHAAEHLTRDTIWIMQKLFASGADGVNFDTTAAAGDGDFYGTLHAIEALRKEFPEMYIEAGMAGEMVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVVNTNTSKTSPWNLARAVTFIKEAVKVSSLPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPLGMPISHIMASGMTGMRAAGDLVARMQFSKNMKIKEAKEYVAKKLNVEIRDLADEYIMRELREELNIGVITSVPGSAKGIAAKMNIEKLLGIKINSCELFRKQTGK
What is the function of this protein?
Catalyzes the transfer of a methyl group from dimethylamine to the corrinoid cofactor of MtbC.
What are the official names of this protein?
Dimethylamine methyltransferase MtbB1, DMA methyltransferase 1, DMAMT 1, Dimethylamine--corrinoid protein methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the dimethylamine methyltransferase family.
Protein: MU1_REOVD
Sequence: MGNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLNPGGVPWIAVGDETSVTSPGALRRMTSKDIPETAIINTDNSSGAVPSESALVPYIDEPLVVVTEHAITNFTKAEMALEFNREFLDKMRVLSVSPKYSDLLTYVDCYVGVSARQALNNFQKQVPVITPTRQTMYVDSIQAALKALEKWEIDLRVAQTLLPTNVPIGEVSCPMQSVVKLLDDQLPDDSLIRRYPKEAAVALAKRNGGIQWMDVSEGTVMNEAVNAVAASALAPSASAPPLEEKSKLTEQAMDLVTAAEPEIIASLAPVPAPVFAIPPKPADYNVRTLRIDEATWLRMIPKSMNTPFQIQVTDNTGTNWHLNLRGGTRVVNLDQIAPMRFVLDLGGKSYKETSWDPNGKKVGFIVFQSKIPFELWTAASQIGQATVVNYVQLYAEDSSFTAQSIIATTSLAYNYEPEQLNKTDPEMNYYLLATFIDSAAITPTNMTQPDVWDALLTMSPLSAGEVTVKGAVVSEVVPADLIGSYTPESLNASLPNDAARCMIDRASKIAEAIKIDDDAGPDEYSPNSVPIQGQLAISQLETGYGVRIFNPKGILSKIASRAMQAFIGDPSTIITQAAPVLSDKNNWIALAQGVKTSLRTKSLSAGVKTAVSKLSSSESIQNWTQGFLDKVSAHFPAPKPDCPTSGDSGESSNRRVKRDSYAGVVKRGYTR
What is the function of this protein?
The viral outer shell polypeptides, of which mu-1 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3.
What are the official names of this protein?
Outer capsid protein mu-1, Mu1.
What is the protein family that this protein belongs to?
Belongs to the orthoreovirus mu-1 protein family.
What are the subcellular locations of this protein?
[Outer capsid protein mu-1]: Virion. Host cell membrane; Lipid-anchor. Host endoplasmic reticulum. Host mitochondrion. Note=Found in the outer capsid. Seems to associate with cell membranes. This association is enhanced by myristoylation.
Protein: 3SE1_DENAN
Sequence: TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDYLEVKCCTSPDKCNY
What is the function of this protein?
Interferes with neuromuscular transmission by inhibiting the enzyme acetylcholinesterase (AChE) present at the neuromuscular junction.  It selectively binds and inhibits with a 1:1 stoichiometry the mammalian and electric fish AChE at picomolar concentrations.  It is highly specific for the peripheral site of AChE and blocks the entry of acetylcholine into the active site of the enzyme, thereby preventing its breakdown.  It has been called fasciculin since after injection into mice it causes severe, generalized and long-lasting (5-7 hours) fasciculations.
What are the official names of this protein?
Fasciculin-1, Fas-1, Fas1, Fasciculin-I, FAS-I, Toxin TA1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Acn-esterase inhibitor sub-subfamily.
Protein: PUR5_SYNJA
Sequence: MDYRSAGVDIELGRAFVKGIRERVEGSQAQSSGSSGTLGGIGGFAGLLELPAGYRAPVLVAGTDGVGTKLEIAQQWGQHRGVGIDLVAMCVNDVLTVGARPLFFLDYIATGKLEPEALWQVIDGILEGCQEAGCQLLGGETAEMPGFYPPGKYDLAGFCVGIVERADVLDSSRVQLGDRLWALPSSGLHSNGFSLVRRIVAERGWPWDHQPPGWDRPLAEVFLTPTRIYVQAVQRLQAAGIPLHGMAHITGGGIPENLPRCLAPEQAARLEPHSWPIPPEFLWLQEQGQVETLEMFNTFNLGVGYVLVIPPEAENRLRSLLPEAFPIGEVVPARPGESRVLGLEEWGSLVP
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_BRASB
Sequence: MTIQQPITAPVPQETAPAEAPAKLTPMMEQYLDIKAAHPGLMLFYRMGDFYELFFEDAEVASKALGIVLTKRGKHQGQDIPMCGVPVERSEDYLHRLIAQGIRVAVCEQMEDPAAARARGNKSVVKRGVVRVVTPGTLTEDNLLDARANNYLLAIARSRGSSGGDRLGLAWIDISTSDFIVTECAFAELTATLARINPNEVIISDALYSDEVFEPVLRELAAVTPLTRDVFDGATAERRLCDYFAVATMDGLAVLSRLETTAAAACVTYVERTQVGQRPPLAPPAREATGSTMAIDPATRANLELTRTLAGERRGSLLDAIDCTVTSAGSRLLAQRLAAPLTEPAQIGRRLDAVNVFVADSAAREDIRAILRGAPDMTRAMARLSVGRGGPRDLAALRDGILAADQALGRLSALDQPPQEIAAAMAALARPARALAEELSRALDEQLPLIKRDGGFVRSGYDSTLDETRNLRDASRLVVASMQARYADQTGVKALKIRHNNVLGYFVEVTAQHGDKLMSAPLNATFIHRQTLAGQVRFTTSELGEIEAKIANAGERALNLELEIFDRLCGQALAIGDDLRAAAHGFAMLDVATALAKLAVDDNYIRPEVDGSLGFAIEGGRHPVVEQALKREGQPFIANSCDLSPTPGHKSGQLWLLTGPNMAGKSTFLRQNALIALLAQIGSFVPATRARIGIVDRLFSRVGAADDLARGRSTFMVEMVETAAILNQAGERALVILDEIGRGTATFDGLSIAWAAIEHLHESNRCRTLFATHYHELTALAAKLPRLFNATVRVKEWHGDVVFLHEVLPGSADRSYGIQVAKLAGLPPAVISRAKSVLAKLEAADRGQNARALVDDLPLFAVPSRAAPEPAMSKEAEELIAAVKALHPDEMTPREAMDALYALKAKLPKG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: PORTL_BPT7
Sequence: MAEKRTGLAEDGAKSVYERLKNDRAPYETRAQNCAQYTIPSLFPKDSDNASTDYQTPWQAVGARGLNNLASKLMLALFPMQTWMRLTISEYEAKQLLSDPDGLAKVDEGLSMVERIIMNYIESNSYRVTLFEALKQLVVAGNVLLYLPEPEGSNYNPMKLYRLSSYVVQRDAFGNVLQMVTRDQIAFGALPEDIRKAVEGQGGEKKADETIDVYTHIYLDEDSGEYLRYEEVEGMEVQGSDGTYPKEACPYIPIRMVRLDGESYGRSYIEEYLGDLRSLENLQEAIVKMSMISSKVIGLVNPAGITQPRRLTKAQTGDFVTGRPEDISFLQLEKQADFTVAKAVSDAIEARLSFAFMLNSAVQRTGERVTAEEIRYVASELEDTLGGVYSILSQELQLPLVRVLLKQLQATQQIPELPKEAVEPTISTGLEAIGRGQDLDKLERCVTAWAALAPMRDDPDINLAMIKLRIANAIGIDTSGILLTEEQKQQKMAQQSMQMGMDNGAAALAQGMAAQATASPEAMAAAADSVGLQPGI
What is the function of this protein?
Forms the portal vertex of the capsid.  This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection.  The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel.
What are the official names of this protein?
Portal protein, Gene product 8, Gp8, Head-to-tail connector.
What is the protein family that this protein belongs to?
Belongs to the podoviridae portal protein family.
What are the subcellular locations of this protein?
Virion.
Protein: RL16_MYCA1
Sequence: MLIPRKVKHRKQHHPRQRGIASGGTAVNFGDYGIQALEHAYVTNRQIESARIAINRHIKRGGKVWINVFPDRPLTKKPAETRMGSGKGSPEWWVVNVKPGRVLFELSYPNEQTARAALTRAIHKLPIKARIVTREDQF
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.