PharMolix/UniProtQA huggingface dataset:
Protein: CASP1_RAT
Sequence: MADKVLRAKRKQFINSVSVGTINGLLDELLEKRVLNQEEMDTIKLANITVMEKARDLCDHVTKKGPRASQMFITYICNEDCYLAEILELQSGPSAETVFVTEDSKGGHPFSSETKEKLNKEGGAFPGPSGSLKFCPLEIAQKLWKENHSEIYPIMKTPTRTRLALIICNTDFQHLSRRVGADVDLREMKLLLQDLGYTVKVKENLTALEMTKELKEFAACPEHKTSDSTFLVFMSHGLQEGICGITYSNEVADILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVGNSEEGFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPDSRLQMPTTERVTLTKRFYLFPGH
What is the function of this protein?
Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides.  Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes.  Cleaves a tetrapeptide after an Asp residue at position P1.  Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD.  In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part.  Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair.  Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive.  In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.
What are the official names of this protein?
Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane.
Protein: PQIA_SHIFL
Sequence: MCEHHHAAKHILCSQCDMLVALPRLEHGQKAACPRCGTTLTVAWDAPRQRPTAYALAALFMLLLSNLFPFVNMNVAGVTSEITLLEIPGVLFSEDYASLGTFFLLFVQLVPAFCLITILLLVNRAELPVRLKEQLARVLFQLKTWGMAEIFLAGVLVSFVKLMAYGSIGVGSSFLPWCLFCVLQLRAFQCVDRRWLWDDIAPMPELRQPLKPGVTGIRQGLRSCSCCTAILPADEPVCPRCSTKGYVRRRNSLQWTLALLVTSIMLYLPANILPIMVTDLLGSKMPSTILAGVILLWSEGSYPVAAVIFLASIMVPTLKMIAIAWLCWDAKGHGKRDSERMHLIYEVVEFVGRWSMIDVFVIAVLSALVRMGGLMSIYPAMGALMFALVVIMTMFSAMTFDPRLSWDRQPESEHEES
What is the function of this protein?
Component of a transport pathway that contributes to membrane integrity.
What are the official names of this protein?
Intermembrane transport protein PqiA.
What is the protein family that this protein belongs to?
Belongs to the PqiA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VPS17_YEAST
Sequence: MTSAVPYDPYDDLDNNPFAEPQEEDSEPAATTTDGSSSMSEERVGTEQTAASVQDNGTANNIQNGLGEEGNATRSKTSNEHNENQQPSQPSERVILPERSDEKKKYTLLAKVTGLERFGSATGKKENPTIIFDCSTNLPTFRKQQYKNVKKSYEEFHQLFKYLNVAIQESFVPTLPSAYTTFGINSEEDRMKVTRNFQLWFNRLSQDPLIIRNEEVAFFIESDFNTYTPINKSKSLASGLKRKTLKQLAPPYDEITELAEFRPLVKSIYVVSQSLQEKLLRVSRNRKMMVQEENAFGQDFVNLDEHNKLYRRYGKILTAVGDIDSIIATMDMATLYDGLEWIVRDAYAVKEALTNRHFIMRNLVQAQQNSKAKQEQARRFRSRRDINPMKIDEALRQLKAAAKNEQVLTLKLQRITSNMIIERKQWISWYEEWIRSSIKEFTLRKIEYERKKLTLLERVRSDIRKADENGGLSRLGRHAVSNNNSDTSQTLKGDSWTGESNRKSQIPINKIAHTEFDDELFTEDDGYNSQDSDTTSLNARHAASLLGMSTK
What is the function of this protein?
Plays a role in vesicular protein sorting.  Required for the sorting and delivery of a subset of soluble vacuolar hydrolases.  Required for retention of late Golgi membrane proteins and vacuolar biogenesis.  Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.  The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 17, Carboxypeptidase Y-deficient protein 21.
What is the protein family that this protein belongs to?
Belongs to the VPS17 family.
What are the subcellular locations of this protein?
Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Note=Membrane-associated on the cytoplasmic side of either the Golgi complex or an intermediate in Golgi to vacuole transport.
Protein: TM41B_CHICK
Sequence: MAQRRAAAESARHQRLLEGKAQAEGGSARTSLLILVSIFTIAAFLMFLVYKNFPQLSEEEGKCIKIPRDMDDAKALGKVLSKYKDTFYVQVLVAYFATYVFLQTFAIPGSIFLSILSGFLYPFPLALFLVCLCSGLGASFCYMLSYLVGRPVVYKYLTEKAVKWSEQVERHREHLINYIIFLRITPFLPNWFINITSPVINVPLKVFFIGTFLGVAPPSFVAIKAGTTLYQLTTAGEAVSWNSLFVLMILAILSILPALFQKKLKQKFE
What is the function of this protein?
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes.  Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine.  Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly.  In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity).  Required for normal motor neuron development (By similarity).
What are the official names of this protein?
Transmembrane protein 41B.
What is the protein family that this protein belongs to?
Belongs to the TMEM41 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endomembrane system. Note=Localized to specific membrane structures termed mitochondria- associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria.
Protein: IF1C_DIOEL
Sequence: MKEQKLIHEGVIIESLPNGMFRVRLDNEDLILGYVSGRIRRSFIRILPGDRVKIEVSRYDSTKGRIIYRLRNKDSND
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: URE2_KLEP3
Sequence: MIPGEYHVKPGQIALNTGRATCRVVVENHGDRPIQVGSHYHFAEVNPALKFDRQQVTGYRLNIPAGTAVRFEPGQKREVELVAFAGHRAVFGFRGEVMGPLEANDE
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOSQ_BPSPB
Sequence: MIRKEVEEAPWWITETGVIISKKLKKPRKTFITPHGYEMIGYTHPKKGTQNYLVHRLVAKYFIYDIPKGMFVNHIDGNKLNNHVRNLEIVTPKENTLHAMKIGLMSGQPGESNSMSKLTNMEATNLIYDLIAGMNNVEAGEKYSLHPRYVSLIRHKRRWKTLWDRIERSTTIA
What is the function of this protein?
A possible homing endonuclease, it is entirely encoded within the bnrdF intron.
What are the official names of this protein?
Putative HNH homing endonuclease yosQ.
Protein: PAWR_RAT
Sequence: MATGGYRSSGSTTDFLEEWKAKREKMRAKQNPVGPGSSGGDPAAKSPAGPLAQTTAAGTSELNHGPAGAAAPAAPGPGALNCAHGSSALPRGAPGSRRPEDECPIAAGAAGAPASRGDEEEPDSAPEKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAASLPDPGTSYLPQDPSRTVPGRYKSTISAPEEEILNRYPRTDRSGFSRHNRDTSAPANFASSSTLEKRIEDLEKEVLRERQENLRLTRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR
What is the function of this protein?
Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models.  Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity.  Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1.  Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1.  Seems also to be a transcriptional repressor by itself.  May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity).
What are the official names of this protein?
PRKC apoptosis WT1 regulator protein, Prostate apoptosis response 4 protein, Par-4, Transcriptional repressor Par-4-like protein PAWR.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies (By similarity).
Protein: PDXT_BACCN
Sequence: MVKIGVLGLQGAVREHVKAIEASGAEAVVVKQVEQLQEIDGLILPGGESTTMRRLIDKYHFMEPLREFARSRKPMFGTCAGMILLANKLIGYEEAHIGAMDITVERNAFGRQKDSFEATLSIKGVGEDFTGVFIRAPYVVDIADDVEVLSMHNGRMVAVKQGPFLAASFHPELTDDYRVTAYFVEMVEEAKMKKVV
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: FADJ_ECOK1
Sequence: MEMASAFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQIRENKELRGVVFVSAKPDNFIAGADINMIGNCKTAQEAEVLARQGQQLMAEIHALPIPVIAAIHGACLGGGLELALACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQAVKLGLVDDVVPHSILLEAAVELAKQDRPSSRPLPVRERILAGPLGRALLFKMVGKKTEHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRNIFFASTDVKKDPGSDAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPRGINHALKYSWDQLEGKVRRRHLKASERDKQLALISGTTDYCGFAHRDLIIEAVFENLELKQQMVAEVEQNCATHTIFASNTSSLPIGDIAAHAARPEQVIGLHFFSPVEKMPLVEIIPHASTSAQTIATTVKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERIEHIDAALVKFGFPVGPIQLLDEVGIDTGTKIMPVLEAAYGERFSAPANVVSSILNDDRKGRKNGRGFYLYGQKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCLDEQVIRSVRDGDIGAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCDRLVEMSERGESFWKTTATDLQ
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTC1_PHYSA
Sequence: MAFLKKSLFLVLFLALVPLSICEEEKREGENEKEQEDDNQSEEKRGLVSDLLSTVTGLLGNLGGGGLKKI
What is the function of this protein?
The native peptide is a cationic amphipathic alpha-helical antimicrobial peptide with potent activity against both Gram-positive and Gram-negative bacteria (By similarity).  It has weak activity against fungi and shows low hemolytic activity (By similarity).
What are the official names of this protein?
Plasticin-S1, PTC-S1, Dermaseptin-S10, DRS-S10.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Plasticin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS4_METJA
Sequence: MIIIPAVDLKDKKCVQLIQGDPNKKHLELNNPVEVAKKFVDEGAEYLHIIDLDAAFGTGNNRDVIKNIIKEVNVPVEVGGGIRNLEIAKELISLGVDRVIVGTKAILEPKFIDDLNKEIGKDKIVLAVECKEGKVVIKGWKEKVDKTPIEVIKEFEDKVGYILFTNVDVEGLLKGINVDIIKELIEKTDIPIIYSGGITTLEDIKALKELGIYGVVIGSALYKGLIDLKKALEIVKN
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZBT8A_MOUSE
Sequence: MEISSHQSYLLQQLNEQRRQDVFCDCSILVEGKVFKAHRNVLFASSGYFKMLLSQNSRETSQPTTATFQTFSPDTFTVILDFVYSGKLSLTGQNVIEVMSAASFLQMTDVISVCKTFIKSSLDISEKEKDRYFSLSDKDTGSNGVERPPFYSSSWQEEGGSPHSHVSPDPGKPWNKYGYPPASQRSPQRPLAKHEQRKEPSKKAKHVRLPQPSEVVHFKPGKGEAQTDSGNHVSQSEEQVPVDAEVDPAPAGFQYSQGPDGIARSFPDDLTRLRFKCPFCTHVVKRKADLKRHLRCHTGERPYPCQACGKRFSRLDHLSSHFRTIHQACKLICRKCKRHVTDLTGQVVQEGTRRYRLCNECLADVGMESLPADLEAEQHRTAPADGDKDCRWHLSEEENRSYVEIVEDGSADLVIQQVDDSEEEEEKEIKPNIR
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 8A.
What are the subcellular locations of this protein?
Nucleus.
Protein: ASNA_STRTD
Sequence: MKKSFIDQQKEISFVKNTFTQYLIDKLDVVEVQGPILSKVGDGMQDNLNGIENPVTVNVLQIPDATYEVVHSLAKWKRHTLARFGFNEGEGLVVNMKALRPDEDSLDATHSVYVDQWDWEKVIPDGHRNIAYLKETVETIYKVIRLTELAVEARYDIEAVLPKKITFIHSEELVEKYPDLTPKERENAITKEYGAVFLIGIGGVLPDGKPHDGRAPDYDDWTTESEKGYHGLNGDILVWNEQLGHAFELSSMGIRVDEDALKRQVEITGDQDRLKLDWHQALLHGQFPLTIGGGIGQSRMAMFLLRKKHIGEVQTSVWPDAVRETYENIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX24_SCHPO
Sequence: MLRRGALSTILKGLNGLSLRSPIPIWHVSASPEVGSKYNLPTVPTTSHVSYRQIAKANFFAGYRPLSANQICVPKVESKTQVSQSQDEEDQPQEYVLSLEDGYLYAQSFSASGSVTQTQPARISTQVWEQICDKLISITPLDLTSVKRKRKLKMNKHKFKKRLRRQRALRKRLGK
What is the function of this protein?
May be involved in the splicing of the mitochondrial mRNA.
What are the official names of this protein?
Mitochondrial mRNA-processing protein cox24.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS38 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: CD22_PANTR
Sequence: MHLLGPWLLLLVLEYLAFSDSSKWAFEHPETLYAWEGACVWIPCTYRALDRDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHVNDSGQLGLRMESKTAKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGESVTMTCEVSSSNPEYTTISWLKDGTSLKKQNTLMLNLHEVTKDQSGKYCCQVSNDVGPGRSAEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPTPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWGNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESRLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGHSPLSTLTVYYSPETIGRRVAVGFGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGYYNPMMEDGISYTTLRFPETNIPRTGDAETSEMQSPPPDCDDTVTYSVLHKRQMGDYENVIPDFSEDEGIHYSELIQFGVGERPQAQENVDYVILKH
What is the function of this protein?
Mediates B-cell B-cell interactions.  May be involved in the localization of B-cells in lymphoid tissues.  Binds sialylated glycoproteins; one of which is CD45.  Preferentially binds to alpha-2,6-linked sialic acid (By similarity).  Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling.  Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules.
What are the official names of this protein?
B-cell receptor CD22, Sialic acid-binding Ig-like lectin 2, Siglec-2.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RL3_SYNFM
Sequence: MIKAIVGRKLQMSQIFAEDGTAVPITLIQAGPCTVTQVKTPERDGYSALQIGFGSRKPKNVNKPMKGHLDKVGKGYFEVLREIRMENASDHEVGEDLAADVFEIGERIDVIGTTKGKGYAGTIKRWGFQRGPSGHGSKNIREPGSTGNATFPGRVIKGKKMPGQKGNKRTTVMNLRIIDVRPEENLLIVKGAVPGSQNGIVLIRKTNRAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PACA_CLAMA
Sequence: MAKSSRATLALLIYGILMRYSQCTPIGMGFPNMRLDNDVFGDEGNSLSELSYEPDTMSARSRPALPEDAYTLYYPPERRAETHADGLLDRALRDILVQLSARKYLHSLTAVRVGEEEEDEEDSEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGRRYRQRFRNKGRRLVVPSVWTGIRDTVIITPEKRGKRY
What is the function of this protein?
PACAP plays pivotal roles as a neurotransmitter and/or a neuromodulator.
What are the official names of this protein?
Glucagon family neuropeptides.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSBP3_MOUSE
Sequence: MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFHDYSAAAAPSPVLGNIPPNDGMPGGPIPPGFFQGPPGSQPSPHAQPPPHNPSSMMGPHSQPFMSPRYAGGPRPPIRMGNQPPGGVPGTQPLLPNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQNYGSGMRPPPNSLGPAMPGINMGPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGPPGTPIMPSPADSTNSSDNIYTMINPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNGSLGSGDIDGLPKNSPNNISGISNPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV
What is the function of this protein?
May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.
What are the official names of this protein?
Single-stranded DNA-binding protein 3, Lck-associated signal transducer, Sequence-specific single-stranded-DNA-binding protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURC_AERHH
Sequence: MTKVELAKLRTVIPEMRRVRRIHFIGIGGAGMGGIAEVLANEGYQVTGSDLARNAVTERLESLGAHIFVGHSAEHVNEASVVVVSTAIKQDNPELLAARELRIPVVRRAEMLAELMRFRHGIAIAGTHGKTTTTSLVASIYAEADRDPTFVIGGLLNSAGTNARLGSSRYLIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFSKLKATFIDFLHNLPFYGLAVVCVDDPVIRGMLPEIARPTITYGLSDDADVQVLDFVQTSNRSRFRVRRKDAGELEVTLNLPGIHNALNAAAAIAVATEDGIGDDAIIRALAKFEGVGRRFQQYGEFETGRGKAMLVDDYGHHPSEVKVTINAARAGWPEKRLVMVFQPHRYTRTRDLYEDFADVLSKVDVLVMLEVYAAGEEPIPGADGRALCRSIRSRGSLEPIFVATPDDVPAVLAGLVGEGDLVLTQGAGNVGALARRLGEMKLSIESMKSGA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METAA_CAMJJ
Sequence: MPLIIPENIPAYELLKEHAFIMGLRRAKHQDIRPQEILIVNLMPKKIETENQILSLLANSPLQVNITLLATTSYVGKNTPFTHLEKFYKGLEEVKKHKFDGAIVTGAPVEQMDFEKVAYWEELLEIFDFLKQNVTSSMYICWGAMAALKYFYGVDKISLDKKIFGVYKHDKVSPDLLLTNLDEKVLMPHSRHSSMDEEQILALQKQGKLKILLRNKKIGSALLRDEKNIFILGHLEYFKETLHQEYVRDNFIQKAKNYYDKKGNIKYNWRSNANTIFANWLNYDVYQSTPFVL
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_HELPJ
Sequence: MPHFLAKLDSKPLEYPLIRGDFCFHREFLSLKHPTKSCVHASFKNDVFLLQKIRRAGDFLIKSEKATPLKREILKQALRIYSQSFEVISHNLQENSKHASQKKALDLETFEDFIQKNQAPILIEIGFGSGRHLIELAKNNPTTTCLGIEIHTPSIAQALKQIELLDLKNLHILQGDGRLVLESMPNHRCEKIFVHFPVPWNEKKHRRVLSEKFLNEALRVLKPRGFLELRTDDSLCFEDSLKLALKNFQCEIEIKKNAQIPVVSKYEARWNKLKKDIYDLKIYSLGLDENPTQNHALDFSFDTITIDKESVGAILKTPKIIKEGYFVHVCNIYENKGDFLVELSMGDFDWPVRLFVLLAENQVFYLNKSPLKTLNNHKAHLLLQNILSQKELDERDHRSE
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: NRP2_RAT
Sequence: MDMFPLTWIFLALYFSGHKVRSQQDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWVVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSVLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPRMEIILQFLTFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSKLRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPPENFQCNAPLGMESGRIANEQISASSTFSDGRWTPQQSRLHGDDNGWTPNVDSNKEYLQVDLRFLTMLTAIATQGAISRETQKGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQANNDATELVLNKLHTPLLTRFIRIRPQTWHLGIALRLELFGCRVTDAPCSNMLGMLSGLIADTQISASSTREYLWSPSAARLVSSRSGWFPRNPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAMEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFEPVPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPMDEDATECGENCSFEDDKDLQLPSGFNCNFDFPEETCGWMYDRAKWLQSTWISSANPNDRTFPDDKNFLKLQSDGGREGQFGRLISPPVHLPRSPVCMEFQYQAMGGHGVALQVVREARQESKLLWVIREDQGSEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEISIDDIRISTDVPLENCMEPISAFAVDIPEIHGGEGYEDEIDDDYEGDWNNSSSTSGAGSPSSGKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKINHQKCCSEA
What is the function of this protein?
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
What are the official names of this protein?
Neuropilin-2, Vascular endothelial cell growth factor 165 receptor 2.
What is the protein family that this protein belongs to?
Belongs to the neuropilin family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: ALR1_OCEIH
Sequence: MKVTSYRDAWVEVSLDALTYNVRQFKNHLQEKSRLMAVVKADGYGHGAVPIARRSLEAGAEYLGVAFIDEALQIREAGILAPILLLGFTPSYAVREAVRHDLTLTVYSTETLEAIKDAARSLDKKAKIHIKVDSGMSRIGLRSSEEVISLMTSLQTEEIEVEGIFTHFADADNDESDAYTYKQFETFQGIMEALENEGYSIPIKHCCNSAATIAFPDMHMDMVRVGISLYGLYPGQHLKEILSLQQVMSFKAKPVLIKDVPPHQPISYGLTYETKETSKIATLPIGYADGFSRLLSNVGHVTVHGTACPIVGRICMDQSMIDVSEVQTDVTKDDIVTIFGDENAGYIPLDVVAEQMQTIHYETVCLIGKRVPRHYV
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase 1.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: YABA_PEDPA
Sequence: MDKKDLFDQITEVTRNTEDLLNKLHETQSAMVEIMEENAELQIENQHLRERLKQATAAENEGTKNTKYGLSKSLQNLEKLYASGYHVCNEFYGKHRQDEEECAFCLTVIYGDR
What is the function of this protein?
Involved in initiation control of chromosome replication.
What are the official names of this protein?
Initiation-control protein YabA.
What is the protein family that this protein belongs to?
Belongs to the YabA family.
Protein: TRHO_BUCA5
Sequence: MSILHNIVSKKELKRRMFFETEPRLTLSFYKYFFIKNTQEYRDRLYKNFYKYNVLGRIYVASEGINAQISVPKKYYSILKKFLYNFDIELNNLRINKSLDNEKSFWVLCVKIKKKIVQDGIKEHFFNPNNVGIYIQSEQVNSMLNDKKTIFIDMRNSYEYAIGHFENAIEIKSITFREQLKKVIQLMAYAKNKKIVMYCTGGIRCEKATSWMLFNGFKHVYHLEGGIIGYVHDARKNGLPVLFKGKSFVFDNRMSEKISDEVISYCKQCGKSSDVYINCKYSSCHLLFIQCENCSVKFHSCCSLECMKKYNFYMLNNDLKKISY
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.