PharMolix/UniProtQA huggingface dataset:
Protein: IF4A3_PIG
Sequence: MAATATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
What is the function of this protein?
ATP-dependent RNA helicase.  Involved in pre-mRNA splicing as component of the spliceosome.  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation.  The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC.  Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex.  Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions.  Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed.  Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly.  Involved in craniofacial development.
What are the official names of this protein?
Eukaryotic initiation factor 4A-III, eIF-4A-III, eIF4A-III, ATP-dependent RNA helicase DDX48, ATP-dependent RNA helicase eIF4A-3, DEAD box protein 48, Eukaryotic translation initiation factor 4A isoform 3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites.
Protein: SYC_ECOUT
Sequence: MLKIFNTLTRQKEEFKPIHAGEVGMYVCGITVYDLCHIGHGRTFVAFDVVARYLRFLGYKLKYVRNITDIDDKIIKRANENGESFVALVDRMIAEMHKDFDALNILRPDMEPRATHHIAEIIELTEQLIAKGHAYVADNGDVMFDVPTDPTYGVLSRQDLDQLQAGARVDVVDDKRNPMDFVLWKMSKEGEPSWPSPWGAGRPGWHIECSAMNCKQLGNHFDIHGGGSDLMFPHHENEIAQSTCAHDGQYVNYWMHSGMVMVDREKMSKSLGNFFTVRDVLKYYDAETVRYFLMSGHYRSQLNYSEENLKQARAALERLYTALRGTDKTVAPAGGEAFEARFIEAMDDDFNTPEAYSVLFDMAREVNRLKAEDMAAANAMASHLRKLSAVLGLLEQEPEAFLQSGAQADDSEVAEIEALIQQRLDARKAKDWAAADAARDRLNEMGIVLEDGPQGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_PASMU
Sequence: MNDKLALIKSSIKSIPNHPKEGIIFRDITSLLEVPAAFQTVVDLFVTRYKEKGITKVLGTESRGFIFGAPVALALNVPFVLVRKPGKLPRETISQTYQLEYGQDTLEIHTDAIHAQDKVLIIDDLLATGGTVEATVKLVQRLGGDVQDAAFVINLPDLGGEARLNALGIDAYTLVDFAGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TACC1_CAEEL
Sequence: MSLNTTFTKEDGTEVVIPFNGSQNGHPENEEPEVEEAAEPSSSVETLCGATRGDIIVMKHTTKALTELIERLLHSDEFEVRRCSNGQIISQGRCNGTTPGNGIGGGGASSEELEKALKDRDAARAEADKLHANYATLFASFNTVREAANDIRGEYEDARDKLKLAAAEVDEWQAKFLAVKDNANSELERASVEYDDLLRSHDENTKGLRLRVKRQEIELSSKNDEIKVLTNRVSELSQICDQLLNDVDVSDGMSVISTDA
What is the function of this protein?
Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length (PubMed:12956950, PubMed:12956951, PubMed:16054029).  Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis (PubMed:12956950, PubMed:12956951).  In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle (PubMed:12956950, PubMed:12956952).  Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly (PubMed:12956952).  At anaphase, the complex is required for mitotic spindle positioning in one-cell stage embryos (PubMed:17666432).  The complex acts in a partially redundant manner with the tac-1/zyg-8 complex to regulate microtubule assembly and processes during interphase, mitosis and meiosis in embryos (PubMed:17666432).  Plays a role in injury-induced axonal regrowth, regeneration and microtubule stability in PLM neurons and this may be downstream of efa-6 (PubMed:26339988).
What are the official names of this protein?
Transforming acid coiled-coil-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the TACC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Chromosome, centromere, kinetochore. Cell projection, axon. Perikaryon. Note=Initially enriched at meiotic spindle poles, but then recruited to the sperm centrosome (PubMed:12956950, PubMed:12956951). Localized to centrosomes early in pronuclear migration (PubMed:12956952). Centrosomal localization is dependent on air-1, tbg-1 and zyg-9 and is also controlled during the cell cycle, with high expression during prophase and metaphase, but with expression reducing from anaphase to telophase (PubMed:12956950, PubMed:12956951, PubMed:12956952). Accumulates at the centrosome during interphase, ready for the next mitotic cycle (PubMed:12956951). Cycles between cytoplasm and centrosome during mitosis in a cell cycle- dependent manner (PubMed:12956950, PubMed:17666432). Diffuse localization along the axon and localizes to perinuclear spots in the perikaryon (PubMed:26339988). Following injury co-localizes with efa-6 and ptrn-1 in puncta of the perikaryon (PubMed:26339988). The zyg- 9/tac-1 complex localizes to centrosomes throughout the cell cycle and the kinetochore of metaphase and early anaphase chromosomes (PubMed:12956952).
Protein: AP3B2_HUMAN
Sequence: MSAAPAYSEDKGGSAGPGEPEYGHDPASGGIFSSDYKRHDDLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERIDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSEEDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYDQNYDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKPAPVLESSFKDRDHFQLGSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLTLTDSTLVPSLLSPVSGVGRQELLHRVAGEGLAVDYTFSRQPFSGDPHMVSVHIHFSNSSDTPIKGLHVGTPKLPAGISIQEFPEIESLAPGESATAVMGINFCDSTQAANFQLCTQTRQFYVSIQPPVGELMAPVFMSENEFKKEQGKLMGMNEITEKLMLPDTCRSDHIVVQKVTATANLGRVPCGTSDEYRFAGRTLTGGSLVLLTLDARPAGAAQLTVNSEKMVIGTMLVKDVIQALTQ
What is the function of this protein?
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes.  The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.  AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.  In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
What are the official names of this protein?
AP-3 complex subunit beta-2, Adaptor protein complex AP-3 subunit beta-2, Adaptor-related protein complex 3 subunit beta-2, Beta-3B-adaptin, Clathrin assembly protein complex 3 beta-2 large chain, Neuron-specific vesicle coat protein beta-NAP.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes large subunit family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein: H13F1_CYRHA
Sequence: MKTAIFTVVLALAVFAVLSFGWEANEKALSEEFTELIHEKEAASETEARECRYFWGECHDRMPCCDWLVCRYKWPITYNICVWNRTFPEK
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U7-theraphotoxin-Hhn1e, U7-TRTX-Hhn1e, Hainantoxin-XIII-6, HNTX-XIII-6.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 13 (Hntx-13) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1028_STUS1
Sequence: MRLIIVSGRSGSGKSTALNVLEDNGFYCIDNLPAGLLPELAERALLHTELLHPQVAVSIDARNLPSQLKRFPELLEEVRARHIQCDVLYLDADDETLLKRFSETRRRHPLTNESRSLAEAIRDEELLLAAIIDHADLKIDTTHLNLYQLRDMLKLRLLNKPEPGTAFLIESFGFKRGMPVDADLVFDVRCLPNPYWKAELRDFSGLDQPVIDYLAAQPDVEEMFQDIHAYLNKWLPRFAASNRAYVTIAIGCTGGHHRSVYLAERLGLALKEPLKNLQVRHRDLA
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein PST_1028.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: PUR2_ZYMMO
Sequence: MNVLLIGTGGREHALAWKIAQSPSLDTFYATTGNPGIAKLAKPADITVTDHAAVVRFCQDNAIDLVVIGPEAPLVDGLGNSLRAASIAVFGPDKAAAQLEGSKGFTKDLCARYNIPTARYQRCRSAEEAKAALDNFSTPVVIKADGLAGGKGVIIAESRLEAEQAIQDMTAGAFGKAGLEIVVEEFMQGEEASFFAISDGETVRPFGTARDHKRVGDGDTGPNTGGMGAYSPATRLTADLEKRVMQEIVTPTVQAMKEQGMPFVGILYAGLMLTSEGPKLIEYNARLGDPECQVLMMRLESDILPLLYAAATGKLQAQPEPTFSKDYAVTVVIAAQGYPASPKKGGIITRLNEAEANGAVVFQAGTTLDNQTLKANGGRVLNVTAKAADFNAARDLAYQAVNVIDYPDGFWRGDIGL
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: RSMG_ECOBW
Sequence: MLNKLSLLLKDAGISLTDHQKNQLIAYVNMLHKWNKAYNLTSVRDPNEMLVRHILDSIVVAPYLQGERFIDVGTGPGLPGIPLSIVRPEAHFTLLDSLGKRVRFLRQVQHELKLENIEPVQSRVEEFPSEPPFDGVISRAFASLNDMVSWCHHLPGEQGRFYALKGQMPEDEIALLPEEYQVESVVKLQVPALDGERHLVVIKANKI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_ARAHA
Sequence: MEKFQGYLEFDGARQQSFLYPLFFREYIYVLAYDHGLNRLNRNRSIFLENTDYDKKYSSLIVKRLILRMYEQNRLIIPTKDLNQNSFLGHTSLFYYQMISVLFAVIVEIPFSLRLGSSFQGKQLKKSYNLQSIHSIFPFLEDKLAHFNYVLDVLIPYPIHLEILVQILRYWVKDASSLHFFRFCLYEYCNCKNFYIKKKSILNPRFFLFLYNSHVCEYESIFFFLRKRSSHLRSPSYEVLFERIFFYGKIQHFFKVFINNFPAILGLLKDPFIHYVRYHGRCILATKDTPLLMNKWKYFFVNLWQCYFSVWFQSQKVNINQLSKDNLEFLGYLSSLRLNPLVVRSQMLENSFLIDNVRIKLDSKIPISSIIGSLAKDKFCNVLGHPISKATWTDSSDSDILNRFVRICRNISHYYSGSSKKKNLYRIKYILRLCCVKTLARKHKSTVRAFLKRLGSGLLEEFLTGEDQVLSLIFPRSYYASKRLYRVRIWYLDILYLNDLVNNE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL22_SHEB8
Sequence: MEVLAKHRFARTSAQKARLVADQIRGLPVAKALEILTFSPKKAAVLVKKVLDSAIANAEHNEGADIDELKVGAVFVDEGPTMKRIMPRAKGRADRIMKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: Y1529_CELJU
Sequence: MEFPLDPLLTPIEARVLGALMEKQLTTPDAYPLTLNSLLLACNQKTSREPVSHYESGEVQRCINELQERKLVEVDWGARAARYDQRLTRVVSLDKAAQALLCVMMLRGPQTLSELLTRTQRMFDFGSTQAIEEKLQHLCVKTHPAFMHIPRLAGQREDRYMHLLSGAPDLEALAAQTHNRSERNDDGRTQLEERVTLLENQLAELQAQVARLLEKSAE
What are the official names of this protein?
UPF0502 protein CJA_1529.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: FAS1_SCHAM
Sequence: MEGPRLTALMLLLLLTLAADRASAKGEKSLEYKIRDDPDLSQFYSWLEHNEVANSTLQLRQVTVFAPTNLAFQNYKARDGDENIILYHMTNLAHSLDQLGHKVLSELDGNPPLWITRRRDTIFVNNARVLTERSNYEAVNRHGKKQVLHVVDSVLEPVWSTSGQLYNPDAFQFLNQSENLDLGLHRVRSFRQRVFQNQKQNDFKLEGKHTFFIPVDEGFKPLPRPEKIDQKVIDGHIIPNHVLFTSATPLDEEYETLAFTDMLRVVISFTMESDGKAHKPYVKSNTVIGDANHATGAVLAEIVKANIPVKNGVVHLIQRPLMVVDNTVKQFLEGFEKEDGPLYKFYQVILDAGGDFINQITEMKDLTLFAPSNAAWSETTANNLLTDRKKFREILNLHIVAEKLSIESIVEQNVKQVPTMADRKNLYFNVVHGPAGNKTVTVEGGGVNATIVQPNIAATNGMVHIINKILGVPYTTVKEKLRTDPMLNKTYHLGEMSDFNKMLDEKHTKFTYFVPRDLAWKKMEVRDPSAHRKLFMKEFTYQVKQILERHLVISDRVYTMGALKKLASNTSSVLPTMRDHLRLRVRETEKSYYVEWQGEWTHIFRPDVECTNGIIHVMDYVFMKEGDIVVGGPDGAGQQVASFAVVASAHLVVLATVRWLLH
What is the function of this protein?
Neural cell adhesion molecule.
What are the official names of this protein?
Fasciclin-1, Fasciclin I, FAS I, FCN.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: ACM5_HUMAN
Sequence: MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
What is the function of this protein?
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.  Primary transducing effect is Pi turnover.
What are the official names of this protein?
Muscarinic acetylcholine receptor M5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: Y1005_METKA
Sequence: MRAELCADLEEALRAGGHEVVRIERACFDIFVRTRDGRAYIVKVLINADGLRREVAEELRRISHFLEAVPVVVALKRHTGPLEKGVVYHRYEVPVLDPLTFARLVEGEPPKAVADRGGQYVVIRADEVDELDVSRVRRRQLRREGGRITLARAEEADVEGVPVELKTPEHVDTGRDRMTRFERRVAELLERMGAERTGKVRRAPFKLLAKDGETVLARAEEGGDRESIALRDVASATGSMGVIVTRERCKDTYVPTIDIGTLEEIKDLEDLKEYLQERDPEERVRRLVEEAGITSPREIAQRTGIRESVIREFLRRMGITDERKV
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein MK1005.
Protein: BIOW_STAAN
Sequence: MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFAAAKIGYHRLFDIKPVNTRYGGRIIFVDDCIDLNHYISFLESTPKQVVYETV
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: RL14_RICAE
Sequence: MIQMQSILEVADNSGAKKVMCIKVLGGSHHMVAKLGDVIVVSVKDAIPGGKVKKGDVYKGVIVRTKTGVVRPDGSTIKFDQNALVLLNKQDEPIGTRVFGPVTRELRAKKYVRIMSLAEEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ACCD_YERE8
Sequence: MSWIERILNKSNITQTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMSARARLHMLLDAGSEVELGSELEPKDILKFKDSKKYKDRLSAAQKETGEKDALVAMKGTLQGMPIVAASFEFAFMGGSMASVVGARFVRAVEQALEDNCPLVCFSSSGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASLAMLGDINIAEPKALIGFAGPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIVRRPVMRQTLASILSKLTHQPQPSVDGVKADAAVADNPGDA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_NITOC
Sequence: MQVTVEATGELERRLTITLPGSDFESKVQERLRSMVPRIKMDGFRPGKVPYKVVERRYGSAVRQEVSDEFVRDSFRDAIKQESLRPAGMPQIEPPQLEAGESFAYTVTFEVLPEIESVKLEGIKIKQPRAEVTDKDIEGVLKKLQEQHIEWEPMERPAQEADGVTITYHGSIEGKPFPGGSKENFFVILGKGTTLKEFEEHLIGVNKGQELTFEITFPEHYGNQELAGKKASFAVKVISVTAPRLPEINEDFAEKLGVKEGGVAALRQEIKASMTRNLEQAVRDRVREQIMDGLLVANPTTLPISLVKEETSILLEQAKNNLAKQGVNPQEISLDESPFVEQARRRVALRLIFSTILEKQEIKADQDKIKQRVTELAASYEDPEEFSRWIFSDRERLSEIENAVMETQIIDWVLDQVEVLDKSMSFEEVVNPQISSAKEKVQD
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: Y969_BACAA
Sequence: MTKNIHDVAYELQKAIAENDDFKTLKESYAAVQADAASKNLFDEFRTMQLSLQQKMMQGQEITEEDNQQAQEVVVRIQQDAKITKLMETEQRLNVVIGDVNKIIMKPLEELYSAQQQV
What are the official names of this protein?
UPF0342 protein BAA_0969.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: RAD17_MOUSE
Sequence: MSETFLRPKVSSTKVTDWVAPAFDDFEANTAITTITASSLTFSNSSHRRKYLPSTLESNRLSARKRGRLSLEQTHGLETSRERLSDNEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLEVKPKQGGSVLLITGPPGCGKTTTIKILSKELGIQVQEWVNPILPDFQKDDYKELLSLESNFSVVPYQSQIAVFNDFLLRATKYSKLQMLGDDLTTDKKIILVEELPNQFYRDPNALHEILRKHVQIGRCPLVFIVSDSVSGDNNQRLLFPRNIQEECSVSNISFNPVAPTIMMKFLNRIVTIEASKNGEKIIVPNKTSLELLCQGCSGDIRSAINSLQFSSSKGENSSWSKKKRMSLKSDAAISKSKQKKKHNSTLENQEIQAIGGKDVSLFLFRALGKILYCKRAPLTELDSPRLPAHLSEHDRDTLLVQPEEIVEMSHMPGDFFNLYLHQNYIDFFAEVDDLVPASEFLSFADILGGDWNTRSLLREYSTSVATRGVMHSNKARGFAHCQGGSSFRPLHKPQWFLIQKKYRENCLAAKALFVDFCLPALCLQTQLLPYLALLTIPMRNKAQISFIQDVGRLPLKRSFGRLKMEALTDRELGLIDPDSGDESPHSGGQPAQEAPGEPAQAAQNADPETWSLPLSQNSGSDLPASQPQPFSSKVDMEEEEEEEEDIIIEDYDSEET
What is the function of this protein?
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage.  Has a weak ATPase activity required for binding to chromatin.  Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation.  May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination (By similarity).  Essential for embryonic development.  May be involved in homologous recombination.
What are the official names of this protein?
Cell cycle checkpoint protein RAD17.
What is the protein family that this protein belongs to?
Belongs to the rad17/RAD24 family.
What are the subcellular locations of this protein?
Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
Protein: RL6_HAEDU
Sequence: MSRVAKAPVNIPAGIEVKINGQLLTVKGKNGELSREIHNAVEVNQDANALTFVPREGVANADAQAGTARALVNAMVIGVTEGFTKKLQLVGVGYRAQMKGNVVALSLGYSHPIEHTLPLGVTGECPSQTEIILKSADKQLIGQVAADIRAYRRPEPYKGKGVRYSDEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SGT2_USTMA
Sequence: MSQQTPLAYAVAQWLQQSSTSVPADQKAKLQQAAKSVSEAFGVDTSSAEQQAQYGSGPGLQAIFDIFLKTQAKMGAAPAPAAASSSSTAPAAAAATPSDEDLAKAEQLKAEGNKAMSAKDYGAAIEAYGKAIELNPNSPVYFSNRAAAFSQIGQHDSAIDDAKQASKIDPKFGKAYSRLGHALFSSGRYQEAVEAYQKGVEVDPSNEVLKKGLAASKEQLSSSSSSNANDATASRGAADAVSAPSAGADAGAGAGGFPNFGGGAGGMPDLAAMMNNPMIAQMAQNLMSNPDSLASLMNNPMLRQAAERFGSGGGMPDMSSMMNDPALRDMARNFMGGAGRGAGGNGGNNMYG
What is the function of this protein?
Co-chaperone that binds to the molecular chaperone Hsp70 and regulates Hsp70 ATPase activity.
What are the official names of this protein?
Small glutamine-rich tetratricopeptide repeat-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the SGT family.
Protein: RS17_DESAH
Sequence: MNERGRKRVLLGTVVSNKMDKSVVVEVERLVQHRVYKKYITSHKKYAAHDETQLCQIGDMVKITESRPLSKTKRFRVSEIVKKAV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: TRUA_EHRRG
Sequence: MRYKIVIEYDGSNFIGWQKQNHNSNSIQEILEKAIFKFSKQHVTVYGAGRTDAGVHALGQVAHFDLTTDFETYIVRNAINYHLISHAIAVVHVEKTDTDFHARFSAKRRYYLYKIVNRYSPLTIDRNRAWLVHTPLNVENMIKAVCYIKGNHNFSSFRAKCCQSKSPVKTVDNLSITYNHPYIDINISAISFLHHQVRIIVGTLVECGKGYFPPEHIKTIMEANNRSYAGTTAPSYGLYFVKVDYS
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.