PharMolix/UniProtQA huggingface dataset:
Protein: MUTS_FRATN
Sequence: MQDISNHTPMIQQYLKIKSQYQDILLFYRMGDFYELFFDDAKKAAELLDITLTARGKSNGESIPMAGVPYHAAEAYIAKIVKKGLSIAICEQTGDPNTSKGPVERQVTRIITPATVSEEAFLDSNQDSILVSIFEKNNKYYLAYTSYTQGKIYLVKTLTSLNELKNTVLKLSPQEIITNSRELAQQNPFKKPIKALEEWYYSNFEAKKYINDSLDTNIANNILNLYKNDQLTTIGSILSYLTNILKDTPRHITDISYEQEQDTLNIDINSRINLELDNSSKSSLLSIIGKCKTSLGSRLLKRYFSNPTRNLNILATRHNIINSLVENQHFLKIQDVLSYISDIERIISRVALGTVKPKDLVALRDSLEQLPILKKLLSEKNTPEITNINNRIHQLDELVTLLDKAIIENPPATIRDGGVIKEGFDKELDELKSIKDNSYDFLIKFEELQKQKTGISTLKVGYNRVHGYYIELSKQHADKIPTEYIRRQTLKASERYITEELKNFEDKILSSKEKALAREKLIYETLLKKVIEYYKQIQETAASIAEIDVLANFAERAIKLKLSQPKFNNLAKLELKEVRHLAIEHNIDEPFIPNDTLLSKDTNTLQIITGPNMGGKSTYMRQVAQLIFLAYIGSFVPASYADICDIDTIYTRIGASDDISSGRSTFMVEMTETAYILNNASAKSLVIMDEIGRGTSTFDGLALAKACAEKFAQIGAFTLFATHYFELTELAKQYPNVCNIHFEAKEYKDNIYFMHKAVTGAAKKSYGIQVAKLAGISQDVLESAKQNLYNLEKKQHLAESTQIQAQFELEPTTQNPLQQKLDAIDINTITPLEALNILFELKKR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: TBPL1_XENTR
Sequence: MDADSDVALDIIITNVVCVFRTRCHLNLRKIALEGLNVIYKREVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKVGARRLARSLQKLGFQVKFTEFKVVNVLAVCTMPFEIRLAEFTKQNRPHASYEPELHPAVCYRIKSLRTTLQIFSTGSITVTGPDVKSVATAIEQIYPFVFESRKAIL
What is the function of this protein?
Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes.  Seems to also mediate the transcription of NF1.  Does not bind the TATA box.  Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis.  Particularly regulates genes that have a role in catabolism (By similarity).
What are the official names of this protein?
TATA box-binding protein-like 1, TBP-like 1, TATA box-binding protein-related factor 2, TBP-related factor 2, TBP-like factor.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS13_BUCAP
Sequence: MARIAGINIPEHKHALIALTSIYGIGKKRSKIICFNANIAENSKISDLKEEEIELLRENVAKYVTEGDLRREKTLNIKRLIDLNCYRGLRHRRSLPVRGQRTKTNARTCKGPRKAIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RS5_STRP8
Sequence: MAFKDNAVELEERVVAINRVTKVVKGGRRLRFAALVVVGDGNGRVGFGTGKAQEVPEAIRKAVEAAKKNMIEVPMVGTTIPHEVYTNFGGAKVLLKPAVEGSGVAAGGAVRAVIELAGVADITSKSLGSNTPINIVRATVEGLKQLKRAEEVAALRGISVSDLA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RS17_ECOSE
Sequence: MTDKIRTLQGRVVSDKMEKSIVVAIERFVKHPIYGKFIKRTTKLHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAVL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: VHL2_VIOHE
Sequence: GLPVCGETCFTGTCYTNGCTCDPWPVCTRN
What is the function of this protein?
Probably participates in a plant defense mechanism.  Has hemolytic activity.
What are the official names of this protein?
Leaf cyclotide 2, Vhl-2.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebius subfamily.
Protein: SYE2_CAMC5
Sequence: MLVTRFAPSPTGYLHIGGLRTALYNYLYARANGGKFLLRIEDTDLKRNSEEATQAIKEAFAWCKLDHDGEVTYQSRRFEIYKEYVAKLLAEGKAYKCYMSKEELDELRKEQEARKERPKYDNRYRDFTGTPPAGIEPVIRIKAPLSGEILIRDGIKGEVKFKVEDILDDFIIARSDGTPTYNFTVVVDDALMGVTHVIRGDDHLSNTPKQIVLYDALGFKRPEFFHVAMINGEDGKKLSKRHGATDVMEYKRMGYLPEALLNFLVRLGWSHGDDEIFSIEDMLKYFDPHDINKSSSTYNAQKLDWLNAHYIKTLPYERLADEMKEFGVDFRALPKGELLLNSLRERSKTLVEMSQSAKAIIDAPAAYDEKAYAKFITPSSLEILAKFAEILTLNLDAAGYEKITNEFLEQNGLKLKDLAQALRVALTGSSVSPSIFEVLEVLGSKEIKQRIQNILKERK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHD_NOCSJ
Sequence: MDDHAADLLAAVAEVARAAEAADGAAPLDEATWLALRHHPERVRSWVRAGGFALVIGADLSLVVHPQARGRGLGAGLLSSALAGLSAGMPLEAWSHGDHPAAAALARSHGFERARELWVMRRQMASALPQLRAPDGVTVRAFRADSGDAEEVLRVNAAAFAHHPEQGSMDATNLAERMAEPWFDPDGLLLATSAAADGGEQVLGFHWTKVHPGDAGAGAGPGVEVGEVYVVGIDPAAQGRGLGKVLTLAGLHHLAGRGVPEVLLYVESDNRPAIAVYAGLGFTHADDDTHVQYRR
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: GUAA_FRATO
Sequence: MTDIHNHKILILDFGSQYTQLIARRVREVGVFCEIFPHDVAADFIKNYQAKGIILSGGPESVYDSDVKAPEIVFELGVPVLGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNLTNNIFSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVAHKNKPFFGVQFHPETTHTENGKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQAIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRKIIGKLFVDIFDEEAAKIENAKWLAQGTIYSDVIESAGNNQSKAHVIKSHHNVGGLPKEMKLKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLGVRILGEIKKEYVETLQKADAIFTEELYKHNLYHDVSQAFGVFLPIKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLPYDFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: YQF1_SCHPO
Sequence: MQTNNPSYFFRSESALQDEKRKEEKSHNPNGNPRNLKAKILNIELDRTTPKKKQFPRLFVCEASHICKLYDLEINKTCKTYKGHSGPVTCCQIESLRKDGKVRHIYTGSWDHTIKKWNVSTGECVETLIGHTDYVKCLLLLEEEGLLLSGSTDASLIVWDVSSQPSRLLYKLTGHSRGIECITRQPNTDIFWTCGSESSIRCWHITKVGGSQLEEEGFWGHQSNVYCLLFDPQDSEALWTASADKTVREWSLYQGIHEETRMEHPDVCTDVLTLADGNIATACRDEEIRVWDTTTGNVKDIYSGHYESVTKILQWKSYLISSSLDQTIRVWDLEYSADNNEADDHPSLGPPSTKLTAEELAELEELMND
What are the official names of this protein?
Uncharacterized WD repeat-containing protein C126.01c.
Protein: GCSH_LACP7
Sequence: MKVLENLVYTKTHEWVRFEDETTALVGLTDYAQQTLGQLVFVNLPQEGDETVTGESFADVESVKAVSDVYCPVTGVVSEINEELLDAPEKINDTPYEAWFAKITDITEKEEFLSPEEYEEFVKKEME
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RS18_AZOVD
Sequence: MARFFRRRKFCRFTAEGVKEIDFKDLNTLKAYISETGKIVPSRITGTKARYQRQLATAIKRARYLALLPYTDSHGR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RS4_PSYCK
Sequence: MARYIGPKLKLSRREGTDLGLKSGVKPYDVKTKKSARPPGQHGVSRNKSSEYSLQLREKQKVKRIYGVLERQFANYYKEAARKRGATGENLLAMLESRLDNVVYRMGFGSTRAEARQLVSHRTVMVKKAGRDEFIRVNIPSIQLQDGDVIAIQEKSREQLRIKNAIELATQRGIPEWLDVDHSKLQGTFKKAPDRIDLPAEINESLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SECA_EHRCJ
Sequence: MLSIAHKIFGSANSRIIKSFYKVVQHINAIEHEFQLLSNEALKNKTIEFKEELKNGKTLDDILVPAFAVVREASKRVLNMRHFDVQLIGGMVLHKGMISEMKTGEGKTLVATLAAYLNALEGKGVHIVTVNDYLAKRDAEWMGELYDALGITVGCILTDTNDLERKNAYQCDILYSTNNNLGFDYLRDNMKFSRSEMVQRGFNYAIVDEVDSILIDEARTPLIISGQVDQDIKMYKKIDNLIYELVEEDYELEEKSKNIFLTEAGTTKIENLLTKHNLIPSNTSLYDIDNIIIMHYIIQALRAHKIFALDKDYIIKNGNIVIIDEFTGRMMDGRRYSDGLHQALEAKEKLNINSENQTLASTTFQNYFRMYTKLSGMTGTAATESEEFLGIYNLQVVQIPTNIPVQRIDLNDDIYCTEEEKFSAVIKFISECHQKLQPVLVGTVSIEKSEMLSKLLTQNKLKHSVLNARYHEQEAYIIAQAGIPGTITIATNMAGRGTDIQLGGNLKMLAKTALANTTDKEAIEIKYKQLSEKVKKDKEIAIQAGGLCVIGTERHESRRIDNQLRGRSGRQGDPGLSKFFLSLEDDLLRIFGSDKIKGVLKKLGMKKDEAIQHTWISRSIEKAQHKVESRNYDIRKSLLKFDNVINEQRKVVFDQRNRILDNDSYDISIIYRDLNSEIVNSIIHDKYYNLDDETYKILSSEFTRIYALTLDYSIISELESKEKVIEYLNKIVDEHFTQKIEEFKSRDQKLWDYAVKKVMIMSLDYLWRDHLAALDSLKCGINLRSIAQKDPLNEFKAEAFSMLENMMNKFYELITQRLSHLRFDIELSETQIPEYNINHTKISRNEKCPCGSGKKFKHCHGM
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: CSM2_MYCTU
Sequence: MSVIQDDYVKQAEVIRGLPKKKNGFELTTTQLRVLLSLTAQLFDEAQQSANPTLPRQLKEKVQYLRVRFVYQSGREDAVKTFVRNAKLLEALEGIGDSRDGLLRFCRYMEALAAYKKYLDPKDK
What is the function of this protein?
This subunit may be involved in monitoring complementarity of crRNA and target RNA.
What are the official names of this protein?
CRISPR system Cms protein Csm2, CRISPR type III A-associated protein Csm2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Csm2 family.
Protein: VATD_METJA
Sequence: MQRVNPTRMELLKLKNKIKLAEKGHKLLKQKRDALIMEFFQIIEQASDLRDKVEAKLAEAYKDLIMAQTVMGTLAVKEAALAAKNDKLEVDMDTKNIMGVTVPTFEIYNVRRKVGERGYSPYGVSSKLDEAAKKFEEALELITELAEIETSIKLLAEEIITTKRRVNALEYVIIPRLKSLKKYISMRLDEMERENFFRLKLIKSRIEKREAEGETV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: HSCA_ECOLC
Sequence: MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLADHEGRHLLPSVVHYQQQGHSVGYDARTNAALDTANTISSVKRLMGRSLADIQQRYPHLPYQFQASENGLPMIETAAGLLNPVRVSADILKALAARATEALAGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADYIREQAGIPDRSDNRVQRELLDAAIAAKIALSDADSVTVNVAGWQGEISREQFNELIAPLVKRTLLACRRALKDAGVEADEVLEVVMVGGSTRVPLVRERVGEFFGRPPLTSIDPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPALPAGGAHIRVTFQVDADGLLSVTAMEKSTGVEASIQVKPSYGLTDSEIASMIKDSMSYAEQDVKARMLAEQKVEAARVLESLHGALAADAALLSAAERQVIDDAAAHLSEVAQGDDVDAIEQAIKNVDKQTQDFAARRMDQSVRRALKGHSVDEV
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU.
What are the official names of this protein?
Chaperone protein HscA, Hsc66.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RDGC_PSEPF
Sequence: MWFKNLLIYRLTQDLPVDAEALETALATKLARPCASQELTTYGFVAPFGKGEDAPLVHVSGDFLLISARKEERILPGSVVRDAVKEKVEEIEAEQMRKVYKKERDQIKDEIIQAFLPRAFIRRSSTFAAIAPKQGLILVNSASPKRAEDLLSTLREVIGTLPVRPLTVKTAPTAVMTEWVTTQQAAPDFFVLDECELRDTHEDGGIVRCKRQDLTSEEIQLHLSTGKVVTQLSLAWQDKLSFMLDDKMTVKRLKFEDLLQDQAEQDGGDEALGQLDASFTLMMLTFGDFLPALVEALGGEETPQGI
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: UBXN8_MOUSE
Sequence: MASRGVVGLFLLSALPLLCLELRRGIPSLGIKDLILLSGRIFLLLALLTLVISVTTSWFNSLKPSQGHLKEGEKENEKRRRLVRERQQEAQGEKASRYIENVLKPQQEMKLKKLEERFYQMTGETWKLTAGHRLLEGDEDSEFENSSQASFETINGEAARRQNLPKFSTEISPAARPLLRKEVPDLPEEPSETAEEVVTVALRCPNGRVLRRRFFKSWNSQVLLDWMMKVGYHKSLYRLSTSFPRRALEVEGGSSLEDIGITVDTVLNVEEKEQSSQ
What is the function of this protein?
Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane.  May play a role in reproduction (By similarity).
What are the official names of this protein?
UBX domain-containing protein 8, Reproduction 8 protein, Rep-8 protein, UBX domain-containing protein 6.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CYC_GOSBA
Sequence: ASFQZAPPGBAKAGEKIFKTKCAQCHTVDKGAGHKQGPNLNGLFGRQSGTTAGYSYSAANKNMAVQWGENTLYDYLLNPKKYIPGTKMVFPGLKKPQDRADLIAYLKZSTA
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: WAT_DROME
Sequence: MDDPKIMNIMNGMKSLEDHCQLISDVKDESPMQMFYKDKGVFLTGGTGFFGKIIIEKLLRVTEVGQIYLLIRTKKGKDAFARIEDLFNDPVFAKMKQVNPKYRCQITIISGDCSLPGLGISADERETIMENVNIVLHSAATVRFDEKLKMAIAINVHGTKEIIKLAKEIVNLKALVHVSTAFAHCNMRHIQERFYSGTMSGENAFKLSECLDEHTLNTLTPTIIKGYPNTYTFTKVLAENVVQQSAQNLPVTIFRPGIVITTYREPVTGWIDNMYGPCGVIVGIGSGVLRVFTGDMDNKAHIVPVDMCVNALLASAWDIARNKYETPPIYNYVPDAENMVTWRRYMEDGFEYGCDIPMRKSIWYPRFTIVPHMWQYHILCFLYHTLPALVMDAIMVIIGKKPRMMKIYRKIHKLSNVLKYFSSNEFRFDNDNVRKLTEKLDDRDKRLFAFDMRDLDWTNLFRVSLYGLRLYVVKDDPSNIPESIKRYERLKVLHYTTLAVFYALAAWALYALLKLFL
What is the function of this protein?
Catalyzes the reduction of saturated fatty acyl-CoA to fatty alcohols.  The preferred substrates are C24:0 and C26:0.  Necessary for the final stages of tracheal maturation, to facilitate the transition from water-filled to gas-filled tubes.  May help to maintain the integrity of the outer hydrophobic envelope of the trachea.
What are the official names of this protein?
Fatty acyl-CoA reductase wat, Protein waterproof.
What is the protein family that this protein belongs to?
Belongs to the fatty acyl-CoA reductase family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: BT3L4_DANRE
Sequence: MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLVVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAETKQLTEMLPGILSQLGADSLTSLRKLAEQFPRQVLDNKAPKAEDIDEEDDDVPDLVENFDEASKNEAN
What are the official names of this protein?
Transcription factor BTF3 homolog 4, Basic transcription factor 3-like 4.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
Protein: RL2_SALRD
Sequence: MSIKKRKPTINSQRQYSVDDKEDITTTDPERSLLEPLPNSGGRNNQGRMTMRYRGGGHKRRYRKIDFKRRDKDGIPATVKTIEYDPNRSARISLLAYADGEKRYIITPDGLEVGDTVMNGPQAQAEVGNCLPLTSIPLGTKVHCVEMTPEKGAQMVRAAGTHAQLTAREGDYATLELPSGETRLVPSKCRATVGTTSNVEHENVVLGKAGRKRWLGRRPRTRGVAMNPIDHPMGGGEGLKSGGHPRSREGVPAKGYKTRKRNKESNKYIIRRRTESKQGTGGQ
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SYI_COREF
Sequence: MTEAVGGVYPLVDMTGGSSRFPEMEENVLDFWKRDDTFQASIDQRNDAEDYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYQTMRGYRVPRVFGWDTHGLPAELEAEKQLGIKDKGEIESMGLAQFNDYCAKSVLQYTKEWEEYVTRQARWVDFENGYKTMDLTYMESVIWAFKELYDKGLIYQGFRVLPYSWAEHTPLSNQETRLDDSYKMRQDPTLTVTMPITGKIEGTGANEALIGANAIAWTTTPWTLPSNLALAVNPSVTYALVEVAGDGEEGFVGQQLLLARDLVGAYAKELGTDARIISEHPGTELIGLTYEPVFDFFRDHPNAFQILGADYVTTEDGTGIVHQAPAFGEDDMNVCNAADIAPVIPVDMDGKFTSLTPEYEGQLVFDANKDIIRDLKAKGRVFRHQTIEHSYPHSWRSGEPLIYMALPSWFVNVTKIRDRMVETNQDIEWMPAHIRDGQFGKWLEGARDWNISRSRYWGSPIPVWVSDDENYPRVDVYGSLDELEADFGVRPTSLHRPYIDELTRPNPDDPTGKSTMRRVPDVLDVWFDSGSMPFAQVHYPFENKDWFDTHAPADFIVEYIGQTRGWFYLLHVLSVGLFDRPAFKKVVAHGIVLGDDGLKMSKSKGNYPNVTEVFDRDGSDAMRWFLMSSPILRGGNLIVTEKGIREGVRQAQLPMWNAYSFLQLYASKKATWSVDSTDVLDRYILAKLHDLVADVTAALDATDIARACDQVRWFCDALTNWYVRRSRDRFWAGDEAHPEAFNTLYTVLETLTRVAAPLLPMTTEVIWRGLTGERSVHLTDFPSADSFPADADLVRTMDEIRGVCSAASSIRKAHKLRNRLPLPNLTVALPDSGRLADFLSIIRDEVNVKNVDLTSDVDAVGTFEVVVNAKVAGPRLGKDVQRVIKAVKAGNYERVGETVVADGIELQDGEYTERLVAANPDSTAQIDDVDGLVVLDMEVTPELEAEGWAADVIRGLQDARKSSGFEVSDRIQVTLSVPGDKQEWATRHADHIAGEVLATSFEVTQDDLGEDAHEVLKGVTASVARV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_RALSO
Sequence: MKENTHPNYREVVFQDMSSDFSFVTRSTIQTKESIVWKDGKEYPLAKIEVSSESHPFYTGTQKIMDTAGRVEKFRQKFGSKAGKAAK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: PTH_PERMH
Sequence: MIKAVIGLGNPGKQYEDTRHNVGFMIADVVASLLKCNKKYIERCFSHIYVCEDHYLLIVKPQTFMNNSGVAVKNLLEDYDLKPDEILVVYDDLDLPLGTVRLRKKGSSGGHRGIQSIIESIKTDEFPRIKVGIGRPERKEQVVDYVLSPFKKEEKILLDKVISHTAQCILNVLKYGIDKSLNLCNKKIV
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTCH2_PONAB
Sequence: MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQVCQLPGLFSYAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGKVLQHYQESDKGEELGPGNVQKEVSSSFDHVIKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIITIYREEGILGFFAGLVPRLLGDILSLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGCPPYSPIYTSWIDCWCMLQKEGNMSRGNSLFFRKVPFGKTYCCDLKMLI
What is the function of this protein?
Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane.  Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins.  Does not mediate insertion of beta-barrel transmembrane proteins (By similarity).  Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis.  Regulates the quiescence/cycling of hematopoietic stem cells (HSCs).  Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs).  Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity).
What are the official names of this protein?
Mitochondrial carrier homolog 2.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: RUVB_CUPTR
Sequence: MIETDKLAAPARVIAATPASSQEEAFERALRPKLLDEYVGQEKVRGQLDIFMHAARKRREALDHVLLFGPPGLGKTTLAHIIAREMGVSLRQTSGPVLERPGDLAALLTNLEANDVLFIDEIHRLSPVVEEILYPALEDYQIDIMIGEGPAARSVKLDLQPFTLVGATTRAGMLTNPLRDRFGIVARLEFYTAEELARIVTRSAQLLQARIDPQGALEIARRARGTPRIANRLLRRVRDYAEVKGDGTITREMADAALAMLDVDRVGFDLMDRKLLEAVLHKFGGGPVGVDNLAAAIGEERDTIEDVLEPYLIQQGYLQRTPRGRVATAAAYRHFGLASPQGMAGDAGELFGDA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RAB19_XENTR
Sequence: MPGSNSLEDDPFDFLFKIILIGDSNVGKTCVVHRFQSGVFAHNQQNTIGVDFTVRNMNINGKKVKVQVWDTAGQERFRTITQSYYRSAHGAIIAYDITRRQSFESVPHWIYEAEKYGAANLMMMLIGNKSDLAEKRQILFEEACTLAEKHGLLAVLETSAKESHNVDEVFLLMAKELIARNTFHYHSESPRNSFMLDSKPVLAPPEPDKNCLC
What are the official names of this protein?
Ras-related protein Rab-19.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.