PharMolix/UniProtQA huggingface dataset:
Protein: RSMH_RUBXD
Sequence: MAAAQHRPVMLEEAVRALAPSGGDVVVDATFGGGGHSARVLRELGPGGRVVGIDRDPEARGRAERLLGDPRFSFEQGPYDEVLWRMVGRGERADALLFDLGLSSFQVDDPRRGFSYTREGPLDMRMDPGSGPSAADFLNAAGEAEIAGVLSEYGDVPRAQARRVAREILRRRPLRTTADLREAVRAAVGWAPRGGNPAKRVFQAVRIRVNDELGGLRRALEAAERLLVPGGRLVVISFHSGEDRLVKRFIAEREGRCTCPPELPVCVCGARPVFRRGPVLRPSEREVAENPRSAPARMRVAFRTAEPAREAS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MHX_ARATH
Sequence: MASILNQTQELQESSKVLGHLRCENFFLFPGENTLSDGLRGVLYFLGLAYCFIGLSAITARFFKSMENVVKHSRKVVTIDPITKAEVITYKKVWNFTIADISLLAFGTSFPQISLATIDAIRNMGERYAGGLGPGTLVGSAAFDLFPIHAVCVVVPKAGELKKISDLGVWLVELVWSFWAYIWLYIILEVWSPNVITLVEALLTVLQYGLLLVHAYAQDKRWPYLSLPMSRGDRPEEWVPEEIDTSKDDNDNDVHDVYSDAAQDAVESGSRNIVDIFSIHSANNDTGITYHTVADTPPDSATKKGKAKNSTVFDIWKHQFVDAITLETSESKKVDSIYLRIAKSFWHLLLAPWKLLFAFVPPCNIAHGWIAFICSLLFISGVAFVVTRFTDLISCVTGINPYVIAFTALASGTSWPDLVASKIAAERQLTADSAIANITCSNSVNIYVGIGVPWLINTVYNYFAYREPLYIENAKGLSFSLLIFFATSVGCIVVLVLRRLIIGAELGGPRLWAWLTSAYFMMLWVVFVVLSSLKVSGVI
What is the function of this protein?
Vacuolar transporter that exchanges protons with Mg(2+), Zn(2+) and Fe(2+) ions.  May control the partitioning of Mg(2+) and Zn(2+) between plant organs.  Could also transport Cd(2+) in vitro.
What are the official names of this protein?
Magnesium/proton exchanger, Mg(2+)/H(+) exchanger, AtMHX, Zinc/proton exchanger, Zn(2+)/H(+) exchanger.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. MHX subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: ART10_CANGA
Sequence: MAPKLDIILHPPENGEFYSSDDLISGTIVLDLTKSLSIKQIKVGLKGFTETTTKMDSEYVFPQNGMLGPATENKSYHNLVREERRVFPPDNVWDALEGSSKPFKVKPGHYEYMFQFNKLPSKPMCLKNHTKKTICFVSKSQSTMPPSFNTQWRELNKIDNLDLYFYSFGKIIYVVEVEIEMGRPRTWFKPFDKMLREPKIIEFIPEPKKFASNETVTRSGRNNHGVIDYISKNNSSKSLSAMQESEDGVTAIAPNGPDEKFLARNLDQLDINNDLEYEIEETEENPMKRYKCRYPLGLPDGASMMWVEVRSRDIDTIYRQDFLFRQGSGNFDNVYLIVKGNLSFSDFSNISVKPTRLQLNLLETVSYLSQGIGNENFSSLKLMEIDNLSKSDRPLFDTNELKFISSKNHEIMECEIKLKDNPILKRLQFNEEDYKHRGNRLYSFKTCVITRLFSYQLLIDWNINGQTRQTETIIPVQVFAHKRPPPVNEALPRYVEPPSYDDHV
What is the function of this protein?
May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
What are the official names of this protein?
Arrestin-related trafficking adapter 10.
What is the protein family that this protein belongs to?
Belongs to the ART10 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_MYCPU
Sequence: MAKKEVVKIAKLQFIAGQAKPGPSLAGVGINMPEFTRQFNEQTRDRGNEPVPVEITAYKDKSFDFRLFTAPASFKILQAIKAKSGSANSKTNIIGTLTLAQLEEIAKYKLPDLNTDDYKVAMHTIAGTAKNMGVLVEGWDDVKKAKEEAKAAKLAQLKAEAKEAALKEAEKELVDSKGKEVEVKLVGEEEQSESENN
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: CYSH_VIBVY
Sequence: MLDSVASTLQLSELLSLTKAEQSIRLAEINVELEMLSAQERVAWALQNLEGAHAVSSSFGIQAAVMLHLLSKQQADIPVILTDTGYLFPETYQFIDELTKSLNLNLKVYRANESANWQEARYGKLWEQGIEGIEKYNKLNKVEPMRRALNELNVKTWFSGLRREQSQSRAGLPILSIQNGVFKFLPVVDWSNKDVHYYLKEHGLSYHPLWEQGYLSVGDTHTTQKWEPGMSEEETRFFGLKRECGLHEEDNEQDGSGI
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRDB_LISMC
Sequence: MNRLAVEIPGLSLKNPIMPASGCFGFGQEYSKYYDLNELGAIMAKAVTPEPRLGNPTPRVAETASGMLNAIGLQNPGLEHVLAHELPFLEQFETPIIANVAGATEDDYVQVCARIGESKAVKAIELNISCPNVKHGGIAFGTDPDVAHRLTKAVKNVATVPVYVKLSPNVADIVSIAQAIEAAGADGLTMINTLLGMRIDLKTRKPIIANGTGGLSGPAIKPVAIRMIHQVREVSNIPIIGMGGVQTVDDVLEFLIAGADAVAVGTMNFTDPFICPKLISELPKRMDELGISSLQELKKERTNQ
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIGL9_HUMAN
Sequence: MLLLLLPLLWGRERAEGQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSIKWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQSKATSGVTQGVVGGAGATALVFLSFCVIFVVVRSCRKKSARPAAGVGDTGIEDANAVRGSASQGPLTEPWAEDSPPDQPPPASARSSVGEGELQYASLSFQMVKPWDSRGQEATDTEYSEIKIHR
What is the function of this protein?
Putative adhesion molecule that mediates sialic-acid dependent binding to cells.  Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid.  The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
What are the official names of this protein?
Sialic acid-binding Ig-like lectin 9, Siglec-9, CDw329, Protein FOAP-9.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL17_CHLMU
Sequence: MQHARKKFRVGRTSSHNRCMLANMLKSLIHNERIETTLPKAKELRRHADKMVTLAKKNTLAARRLAVGRLMVRYNTLTGKEARQVKAGDLSAYNVDRRVIGKLFDVLATRFSSRNGGYTRILKLQNRVGDNAQKCIIEFLAD
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: HEMH_RHIE6
Sequence: MTADISLRPADHPAVKSGKVGVLLVNLGTPDGTDYTSMRRYLREFLTDRRVIEWSRWKWYPILFGIVLNRRPQKVGRAYELIWNKEKNESFLRTYTRNQSELMAERLKDLDNVKVDWAMRYGTPSIASRIEALKQEGCDRIVLFPLYPQYAAATTATVNDKAFHKLLSMRWQPALRTVPDYHDDETYIDALAQSVEKHLSSLDWKPDMLIASFHGIPMSYFKQGDPYYCQCQKTGRLLRERLGLTQENFMVTFQSRFGPEEWLQPYTDKTVEKLARDGVKRIAVINPGFVSDCLETLEEIAEQAAHSFHENGGEKFAHIPCLNDSEDGMKVLEKVVRRELQGWV
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_METS4
Sequence: MVTPRRDSGKDRPSLKDARILVVEARYYEDIADELLRGATAAIAAAQAEAEVVTVPGALEIPQAVAILVEAAAREARPYDAVVALGCVIRGETGHYDIVAGESARALMDLSVLLRLPLGNGILTVETEAQAQARARVSEMNKGGGAAEAALAVLALKRAKAAERPDRTIGFTPRRTAETQE
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: CRCB2_STAAS
Sequence: MISIILVMIGGGFGAITRSAITDYFNHKFTSKLPIATLIVNLVGSFLIGLNIGLSISISWFPAFFVTGFLGGLTTFSTLAKELTLMMTPKFNINLFLNYSLLQFIIGFIACYIGYHI
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LIPA_STAHJ
Sequence: MATKNEEILRKPDWLKIKLNTNENYIGLKKMMREKNLHTVCEEAKCPNIHECWGARRTATFMILGAVCTRACRFCAVKTGLPNELDLNEPERVAESVELMNLKHVVITAVARDDLRDAGSNVYAETVRKVRERNPFTTIEILPSDMGGDYEALETLMASKPDILNHNIETVRRLTPRVRARATYERTLEFLRRSKELQPDIPTKSSLMVGLGETIEEIYETMDDLRANDVDILTIGQYLQPSRKHLKVEKYYTPLEFGKLRKVAMDKGFKHCEAGPMVRSSYHADEQVNEAAKEKHRLGEEKLQQN
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRCA_ALISL
Sequence: MITGIQITKAANDDLLNSIWLLDSEKNEARCVVATSGFEADQVIATSALGEYESRDVAIEKAPKVEGGQHLNVNVLQRDTLQDAVKHPEKYPQLTIRVSGYAVRFNSLTTEQQQDVIARTFTETL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: ILVC_RUMCH
Sequence: MAKMYYDSDCNLKLLEGKTVAVIGYGSQGHAHAQNLKDSGVNVIVGLTPSSARRKQVEADGLKAYDTAEAAKMADIIMILVPDEKQAAMYEESIAQNLEAGNILMFAHGFNINFKQIVPPADVDVIMVAPKGPGHTVRSQYKEGRGVPALIAVEKDASGKAKEYALAYASGIGAGRAGILETTFREETETDLFGEQAVLCGGVTELMKAGFETLVAAGYQPEIAYFECIHEMKLIVDLINQGGFGEMRYSISDTAEYGDYVTGKRIITDETRKEMKKVLKEIQDGKFAANWIIENKAAGRANFISMRRNESEHQLETVGAELRKMMSWLKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: TRMD_SALNS
Sequence: MFIGIVSLFPEMFRAITDYGVTGRAVKKGLLNIQSWSPRDFAHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGVDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVARFIPGVLGHEASAIEDSFADGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSU1_HUMAN
Sequence: MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR
What is the function of this protein?
Potentially plays a role in the Ras signal transduction pathway.  Capable of suppressing v-Ras transformation in vitro.
What are the official names of this protein?
Ras suppressor protein 1, RSP-1, Rsu-1.
Protein: ARGD_MYCS2
Sequence: MTLQSRWEAVMMNNYGTPPLSLVSGEGAVVTDADGREYLDLLGGIAVNLLGHRHPAVIEAVTTQLDTLGHTSNLYATEPGIALAEALVGQLGTQARVFFCNSGTEANEVAFKITRLTGKTKIVAAEGAFHGRTMGSLALTGQPSKQAPFEPLPGNVMHVPYGDVAALEAAVDDQTAAVFLEPIMGEGGVVVPPAGYLVAAREITSKHGALLVLDEVQTGVGRTGAFFAHQHDGIVPDVVTMAKGLGGGLPIGACLAVGATGDLLTPGLHGSTFGGNPVCTAAGLAVLKTLAAEDLVARAGVLGKTLSHGIEELGHPLVDKVRGKGLLQGIVLTVPSAKAVETAARDAGFLVNAAAPEVVRLAPPLIITEGQIEAFITALPAVLDTAAEDS
What are the official names of this protein?
Acetylornithine aminotransferase, ACOAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_BUCBP
Sequence: MVALYDYYKNSISKKLMLNFNYSSVMQVPKIDKITLNIGVGIATIDKKNLDFAISDLTKISGQKPLITKARKSIASFKIRKGYPIGCKVTLRGNRKWDFFERLIFIVIPRIRDFRGFSNKSFDGKGNYSIGIKEQIIFPEIDFDKIDRIRGINITITTTALSDREGYALLSAFNFPFRT
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: FEM1B_HUMAN
Sequence: MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33398170, PubMed:33398168).  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33398170, PubMed:33398168).  The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation (PubMed:33398170, PubMed:33398168).  Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS) (By similarity).  Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity (PubMed:24076122).  Promotes ubiquitination and degradation of ANKRD37 (By similarity).  Promotes ubiquitination and degradation of SLBP (PubMed:28118078).  Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (PubMed:10542291).  Also involved in glucose homeostasis in pancreatic islet (By similarity).  May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (PubMed:19330022).
What are the official names of this protein?
Protein fem-1 homolog B, FEM1b, FEM1-beta, Fem-1-like death receptor-binding protein alpha, Fem-1-like in apoptotic pathway protein alpha, F1A-alpha.
What is the protein family that this protein belongs to?
Belongs to the fem-1 family.
Protein: TRI50_MOUSE
Sequence: MAWRLTVPELQDQLQCPICLEVFKEPLMLQCGHSYCKDCLDNLSQHLDSELCCPVCRQSVDCSSSPPNVSLARVIDALRLPGDIEPTVCVHHRNPLSLFCEKDQEFICGLCGLLGSHQHHRVTPVSTVYSRMKEELAGRISELKEEHRNVEEHIGKLVNNRTRIINESDVFSWVIRREFQELHHLVDEEKARCLEGLEGHTRGLVASLDMQLEQAQGTQERLAQAEQVLEQFGNESHHEFIRFHSVASRAEVQQARPLEGVFSPISFKPALHQADIKLTVWKRLFRKVLPAPASLKLDPATAHPLLELSKGNTVVHCGLLAQRRASQPERFDYSTCVLASKGFSWGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNKSPEHGVWLIGLKEGRVYEAFGCPRLPLPVAGHPHRIGVYLHYEQGELTFFDADRPDDLRTLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGHFTLGQV
What is the function of this protein?
E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308).  In turn, promotes starvation-induced autophagy activation.  Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322).  Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (PubMed:36178239).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM50, RING-type E3 ubiquitin transferase TRIM50, Tripartite motif-containing protein 50.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins.
Protein: DYR_CITFR
Sequence: MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNIVISSKPGTDDRVQWVKSVDEAIAACGDEPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: HUTH_BRASO
Sequence: MNAIIAEPGHVSFDDLARVYAGAAIALGPAYWPRVEAAAAIVAKAAQGAEPVYGINTGFGKLASKRIPPDQTALLQRNLILSHCCGVGPATPEPIVRLMIALKIISLGRGASGVRRQIVDQLQAMLAQGVCPFVPQQGSVGASGDLAPLAHMTAVMIGEGQAFVEGRLVPGREALAHVGLDPVTLGPKEGLALINGTQFSTAYALAGLFRARDLLNAALVTGALSVDAAMASTAPFRPEIQALRGHPGQIAAGRVLTELVDGSAIRLSHLEGDERVQDPYCLRCQPQVAGAALDLLTQAARTLVNEANAVTDNPLVLVETGEIISGGNFHAEPVAFAADQIALALSELGAISERRIATLVDPALNFGLPPFLTPQPGLNSGFMIAEVTAAALFAENKQRALPCSIDSTPTSANQEDHVSMAAHAARRLHDMADNLAHIIGIELLVAAQGIELRVPHGTSAALSAVIGALRSHVPALESDRYMADDLAKAAALVAGGALARAANVALGRDSFPRLG
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAT_CHLAA
Sequence: MIPQTSSLPKPHGGVLVERIRVAHPREYDHLPALELDERAYADLELIATGVYSPLEGFMGQADYLSVLEEMRLTNGLPWSIPITLGVSAQDAASYRKTVRLTKDGRTVGLLDVEEQYRPDKEHEALAVYRTTDLAHPGVAALFARGDVYLAGKVQLLTLDRGPFPEHHYTPRETRQLFQERGWQTIVAFQTRNPIHRAHEYLHKVALESLDGLFLHPLVGSTKSDDVPAPVRMAAYKVLLERYYPQNRVLLGVYPAAMRYAGPREAILHAISRKNYGCTHFIVGRDHAGVGNYYGPYEAQAIFDHFRPEEIGIHILKFEQTFYCVTCAAVVSPRTCPHDTQHHLVLSGTRVRELLRAGSPLPPEFTRPEVAEVLRAAYQTL
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
Protein: DNAG_METTH
Sequence: MGKEEISTTKYLIHAQINANGIVEKPDVVGAIFGQTEGLLSNDLDLREFQKTGRIGRIKVNITSRGGKSKGEIIIPSSLDRVETAILAASLETINRVGPCEAYIQVTKVEDVRAVKRKRVVERAKEIYASMMEEVTPESLKMIEEVKEAMRVHEITEYGEEKLPAGPNVETSDAILVVEGRSDVLNLLKYGIKNAIAVEGVSVPKTVADLTRKKTVTAFVDGDRGGELILKELLQVGEIDYVTRAPKGKEVEDLEKDEIMMALRNKVPVEQFYHDLGMKKEKKKTEDKMVLLRNILKELEGTGNAEILDDALNILREVKVENLYDELSRVNNHPYAVVFDGVITQRLVDLSFEKGLRYLVAVRSGDIVKKPHNLKLITGHT
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Also part of the exosome, which is a complex involved in RNA degradation.  Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.
What are the official names of this protein?
DNA primase DnaG.
What is the protein family that this protein belongs to?
Belongs to the archaeal DnaG primase family.
Protein: OMPA_ATLHE
Sequence: LTAKLGYPITDELDIYTRLGGMVWRADSKYNIPGGASFKDHDTGVSPVFAGGLEWAVTRDIATRLEYQWTNNIGDANTVGTRPDNGLLSVGVSYRFGQQEAAAPVVAPAPAPAPEVQTKHFTLKSDVLFNFNKATLKPEGQQALDQMYTQLSNLDPKDGSVVVLGFTDRIGSDAYNQGLSEKRAQSVVDYLISKGIPSDKISARGMGESNPVTGNTCDNVKPRAALIDCLAPDRRVEIEVKGI
What is the function of this protein?
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm.  Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.
What are the official names of this protein?
Outer membrane protein A, Outer membrane porin A, Outer membrane protein 3A.
What is the protein family that this protein belongs to?
Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: PLYC_BACLD
Sequence: MKRLAGTVILSGLLVCGFGQALPEKALAAEVVHKTIVVEKGQTYDGKGKRLIAGPELGDGSQREDQKPIFKVEDGATLKNVVLGAPAADGVHTYGNASINNVVWEDVGEDALTVKSEGSVTINGGSARLAADKIFQINKASTFTVKNFTADQGGKFIRQLGGSTFKAVVNIDNCTITNMKEAIFRTDSSTSSVTMTNTRYSKVGQKWIGVKHATERNNHEF
What is the function of this protein?
Catalyzes the depolymerization of both polygalacturonate and pectins of methyl esterification degree from 22 to 89%, with an endo mode of action.  In contrast to the majority of pectate lyases, displays high activity on highly methylated pectins (By similarity).
What are the official names of this protein?
Pectate lyase C, Pectin lyase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CRCB_LEPIN
Sequence: MNFSKSLLLIAFGGTIGSIFRYLLQYWFGNVLGYSLPWGTLTANLLGSFLIGVVYAISDRFPLFDPQWKFLLASGFCGGFTTFSTFSYETFQMLKSGHYILFLGYICLSVVGGIGFAFAGVWMIKNF
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.