PharMolix/UniProtQA huggingface dataset:
Protein: PFMAY_PESFW
Sequence: MYIQTQFASLLLLAGTSLASQVRKYNFTITSQWSSGDGHGRPVFMINGQSPGPLIEADEGDEIEVFVDNQLAAETTMHWHGIYQIDRPWNDGVPGVTQYSMQPRDTYTYRFTVQQQYGSYFYHGHFGPAFADGMRGPMWIAPAAWRPRPYELISDSSHDVEQMKKAEKHPFHVVISDWNAEPMDILLVMYRDTGIVPWCSNSIVLNGKGRTYCHSAELIESVGGPGRNTLGCLMQPDQELYSNEQVCEATQTDLEIFQAEEGHEWIWINFIHSGAHHELQISVDEHEIVVVAADGEFTYPQRVHAANCNLGERISILVHLNQKPGDYAIRVTSLRQEQVIQGLGILRYPGSSHGAQEAEPPATKPWVHLNGTLISDKLQQMDEMKLAPFPSRPPPPQSDHTLKFFVNMTGTGSWALNIGPHQAFRQQLPPLLWEEDSRGVTTYESDVQGGSMQNGSVVDIIFTNGANVNSQHPFHKHNNKAWVIGTGTGGFPWDTVDEAIQQGGMADSFNFVDPPIRDGCRLGNTTGDWTVIRYDIAFPAASMLHCHMIHHFGAGQQVVLLEGVESMAKIPAEMKDRVHSNFRPPLRYGPLD
What is the function of this protein?
Laccase involved the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment forming a dark layer in the conidial wall that protects the conidia from UV radiations (PubMed:28517364).  The first step of the pathway is the production of the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN or T4HN) by the polyketide synthase PfmaE though condensation of acetyl-CoA with malonyl-CoA.  T4HN is not stable and easily oxidizes into the stable form flaviolin (PubMed:28517364).  T4HN is also substrate of the hydroxynaphthalene reductase PfmaG to yield scytalone (PubMed:28517364).  The scytalone dehydratase PfmaJ then reduces scytalone to 1,3,8-THN (PubMed:31116900).  1,3,8-THN is then substrate of the hydroxynaphthalene reductase PfmaI to yield vermelone (Probable).  Vermelone is further converted by the multicopper oxidase PfmaD to 1,8-DHN (Probable).  Finally the laccase PFICI_06862 transforms 1,8-DHN to DHN-melanin (Probable).  The roles of the 5-oxoprolinase PfmaA and the proline iminopeptidase PfmaB within the cluster have not been elucidated yet (Probable).
What are the official names of this protein?
Laccase PFICI_06862, Conidial pigment biosynthesis oxidase PFICI_06862.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Cell surface.
Protein: IPDE1_MYCTU
Sequence: MQDVEEFRAQVRGWLADNLAGEFAALKGLGGPGREHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARADAPDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPGAGSDLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTEKGSQRHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDDARTDADLVVGAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAAADDPLIRERLTRAWTGLRAMRSYALATMEGPAVEQPGQDNVSKLLWANWHRNLGELAMDVIGKPGMTMPDGEFDEWQRLYLFTRADTIYGGSNEIQRNIIAERVLGLPREAKG
What is the function of this protein?
Involved in cholesterol degradation.  Catalyzes the dehydrogenation of 5OH-HIP-CoA to 5OH-HIPE-CoA (PubMed:32101684).  Can also use octanoyl-CoA and dihydroferuloyl-CoA, with lower efficiency.  Cannot use 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) (PubMed:32101684).
What are the official names of this protein?
Acyl-CoA dehydrogenase IpdE1, 5OH-HIP-CoA dehydrogenase alpha subunit.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
Protein: RL10_DESVM
Sequence: MNRSEKAAIIEQLKARAEGASIAVVTDFKGMSVEELTRLRVKLRENGAEYHVVKNTLARIAFTDGAHDVIKDVFKENCAVALGFADPVAVAKAVTDFAKTSKIFTVRHGSLEGKFLSGEQVSDLAKLPSKPELIARALGTMNAVPTNFVSLFANIIRGLLYALKGIEEKKAAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: Y2626_MYCBO
Sequence: MRTTIDVAGRLVIPKRIRERLGLRGNDQVEITERDGRIEIEPAPTGVELVREGSVLVARPERPLPPLTDEIVRETLDRTRR
What are the official names of this protein?
Uncharacterized protein Mb2626.
What is the protein family that this protein belongs to?
To B.subtilis SpoVT.
Protein: DCUP_AROAE
Sequence: MSRLQNDTFLRALLRQPTDYTPLWMMRQAGRYLPEYCETRRRAGSFLDLCKSPALACEVTLQPLARYDLDAAILFSDILTVPDAMGLGLYFAEGEGPRFERPLRDEWEIRNLVAPDPHAELQYVMDAVAEIRRALGGSVPLIGFSGSPWTLACYMVEGGSSDDYRRIKTMAYTRPDLLHHVLRVTADSVVAYLNAQIESGAQAVMVFDSWGGVLSEAAYREFSLPYLERVVAGLIRERDGERIPSIVFTKGGGLWLESIAAIGCDAVGLDWTMDIGRARALVGDKVALQGNLDPAILFAPPETIATEAKRVLDAFGPHPGHVFNLGHGISQFTPPEAVSVLVDTVHQHSRKLRGGR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURNU_STAS1
Sequence: MQDKFIKKRHILEYEDKQLINVKLGITTREDGLSPYPHNAFNMARYIDDSQQNITKHQEMLATVIGFPREQWVFPIQTHENKVVKVTSNDKGTNIDALNDALHGVDALYTYEPNLLLTMCYADCVPIYFYSEKNHFIGLAHAGWRGTVGQIVNALISNIDFDLNDLNVVIGPATSTSYEINDDIKSKFETLPIDINQYIDTRGTDRHGIDLKRANALLLENAGVPKDNIYITNYATSEDLSLFFSYRVEKGNTGRMLAFIGQ
What is the function of this protein?
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine.  Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate.  Also has adenosine deaminase activity.
What are the official names of this protein?
Purine nucleoside phosphorylase SSP1584, Adenosine deaminase SSP1584, S-methyl-5'-thioadenosine phosphorylase SSP1584.
What is the protein family that this protein belongs to?
Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.
Protein: XGPT_ECO27
Sequence: MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQNTWIEQPWDMGVVFVPPISGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LPXD_POLAQ
Sequence: MLTAIELANQFQASLVGEASTVFNGLAPLERAQSSQISFLSNPLYRKQAADSSAGALIVSKADLEFLQANPGTHSSGRVYFVAKNPYATFARVAQYFARQSAPIYEPGIHSAAVVDPSASIPASCHIGPFVRIGAGVKLGERVAILGNTFVAENCDIASDTLIYPAVSLYFGTQIGERCIIHSGAVIGADGFGFAPDFSATGGEWVKIPQTGNVVIGSDVEIGASTTIDRGAMSDTIIGSGSKIDNQVQIAHNVVVGNCCVIAGCAAISGSTKIGNFCIIGGAANFAGHLTIADRTTVSGNTSIIRSITEPGQHYTGVYPSMLHGAWEKNAAILRGLDKIRQRLRLLDKNKSTES
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: LMLN_DROPS
Sequence: MGLPPLQTQPGTFLVALGLCCWLLATANAHNCQHQHPKAHEVVHGVRIQLADSDDDDAAGSSDAAVHSVRRRSVTAEQPLRILLVYDDSVYRLEEEKFNLINDTVLPEAVQFWEQALMVRETKGIIRLNRKCDSTQVYVKNGHTHCIDQCKATTMCGEVQVPNEHLDVCRVCNATGQNCRIDSNTQPGDGIQNADFVFYVSARQTQRCFKGLTVAYAAHCQQEAALDRPIAGHANLCPESISTKPQELQTLISTVKHEILHALGFSVSLYAFFRDDEGRPRTPRKSETGKPFLNEKLQIHQWSNETIRKVVRENWSVRGGHVNKEVDMMVTPRVVAEARAHFDCDKLEGAELEDQGGEGTALTHWEKRILENEAMTGTHTQSPVFSRITLALMEDSGWYRANYSMATPLSWGKGLGCSFAMRSCKDWIQMNHARGRSIHPFCSKVKQDPLQTECTDDRNSVALCNLIRHDYELPKSYQNFDSLQNVKSGEEGFYGGSVSLADHCPYIQEFTWRSKNIIVRGSHCRFVENNPKPEKNFALESYGHGSKCFDHSEAMWEERSCHQTREWQHWGSGCYKYTCFDGRLHILVGNYTYKCSFPGQKLSIRIAANGWLHKGAIMCPPCHELCGSHFAAQGKQCRPGEEADPLNKYPRDNLACGAESRQQRSVAIISAALLLAAGLRLGHS
What is the function of this protein?
Essential for the coordination of mitotic progression, and also plays a role in cell migration.
What are the official names of this protein?
Leishmanolysin-like peptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M8 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells.
Protein: AB42G_ARATH
Sequence: MTMSQTDGVEFASRNTNENGHDDDDQLRSQWVAIERSPTFERITTALFCKRDEKGKKSQRRVMDVSKLDDLDRRLFIDDLIRHVENDNHVLLQKIRKRIDEVGIDLPKIEARFSDLFVEAECEVVYGKPIPTLWNAISSKLSRFMCSNQAKKISILKGVSGIIRPKRMTLLLGPPSCGKTTLLLALSGRLDPSLKTRGDISYNGHLFSEFVPEKTSSYVSQNDLHIPELSVRETLDFSGCFQGTGSRLEMTKEISRREKLKGIVPDPDIDAYMKAASIEGSKTNLQTDYILKILGLTICADTRVGDASRPGISGGQKRRLTTGEMIVGPIKTLFMDEISNGLDSSTTFQILSCLQQFARLSEGTILVSLLQPAPETFELFDDLILMGEGKIIYHGPRDFVCSFFEDCGFKCPNRKSVAEFLQEVISRKDQEQYWCHIEKTYCYVSIESFIEKFKKSDLGLELQDRLSKTYDKSQTQKDGLCFRKYSLSNWDMLKACSRREFLLMKRNSFVYVFKSGLLIFIGFIAMTVYLRTGSTRDSLHANYLMGSLFFSLFKLLADGLPELTLTISRIAVFCKQKELYFYPAWAYAIPSAILKIPISFLESFLWTMLTYYVIGYSPEMGRFIRQFLILFALHLSCISMFRAIAAVFRDFVVATTVGSISIVLLSVFGGFIVRKPSMPSWLEWGFWLSPLSYAEIGLTANEFFAPRWGKITSENRTLGEQVLDARGLNFGNQSYWNAFGALIGFTLFFNTVFALALTFLKTSQRSRVIVSHEKNTQSSENDSKIASRFKNALPFEPLTFTFQDVQYIIETPQGKKLQLLSGVTGAFKPGVLTALMGVSGAGKTTLLDVLSGRKTFGDIKGQIEVGGYVKVQDTFSRVSGYCEQFDIHSPNLTVQESLKYSAWLRLTSNISSETKCAIVNEVLETIELEEIKDSIVGIPGISGLTTEQRKRLTIAVELVSNPSIIFMDEPTTGLDARAAAIVMRAVKNIAETGRTVVCTIHQPSIDIFEAFDELILMKNGGKIIYYGPLGQHSSKVIEYFMRIHGVPKLKENSNPATWILDITSKSSEDKLGVDLAQMYEESTLFKENKMVIEQTRCTSLGSERLILSSRYAQTSWEQFKACLWKQHLSYWRNPSYNLTRIIFMSFTCMLCGILFWQKAKEINNQQDLFNVFGSMFTVVLFSGINNCSTVLFSVATERNVFYRERFSRMYNSWAYSLAQVLVEIPYSLFQSIVYVIIVYPMVGYHWSVFKVFWSFYSIFCTLLIFNYFGMLLVVVTPNVHIAFTLRSSFYAIVNLFAGYVMPKPNIPRWWIWMYYLSPTSWVLNGLLTSQYGDMEKEILAFGEKKKVSDFLEDYFGYRYDSLALVAVVLIAFPILLASLFAFFIGKLNFQKK
What is the function of this protein?
May be a general defense protein.
What are the official names of this protein?
ABC transporter G family member 42, ABC transporter ABCG.42, AtABCG42, Pleiotropic drug resistance protein 14.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PSBU_SYNJB
Sequence: MRWLLSILVRVVLVLCLCFAPLGIPVVARAAELPPVKHLDTPIDVNNTILRNYRQLPGFYPTLARILVKNAPYKSLEDMLQISGLTEQQKALIKANAENFVFGEYQEGANQLENRINQGYYG
What is the function of this protein?
Stabilizes the structure of photosystem II oxygen-evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation.
What are the official names of this protein?
Photosystem II 12 kDa extrinsic protein, PS II complex 12 kDa extrinsic protein, PSII-U.
What is the protein family that this protein belongs to?
Belongs to the PsbU family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with photosystem II at the lumenal side of the thylakoid membrane.
Protein: PURL_CARHZ
Sequence: MAKWREMGLTDEEYRRIVEYLGREPNEVELGMCAVMWSEHCSYKSSKIHLKKLPTRGPAVVQGPGENAGVVDIGDGLGIAFKIESHNHPSAIEPYQGAATGVGGIIRDIFAMGARPIALLDSLRFGKLHSPRVRHLFTGVVAGIAGYGNCIGIPTVAGDVYFQESYEENPLVNAMCVGIVELSKLKKGVATGVGNPVLLVGATTGRDGIHGATFASEELSQDGEDKRPSVQVGDPFMEKLLLEACLEALEYGHIVGMQDLGAAGLTSSSSEMAARGKSGIRLYLDRVPLREEGMTPYEIMLSESQERMLLVVEKGYEDEIIKIFKKWDLNAVVVGEITDGEEIEVFFDGECVAKLPYRLLTEEAPVYDRPYRIPEIKNLQSINPAGVDCGEALRRLLQSPNIARKSYVYEQYDHQVGVNTVVKPGYSDAAVLRIKGTKKGIAVKTDGNGRYVYHNPREGAKRAVLETALNLAVTGAKPLGLTNCLNFGNPEKPEIMGQFVEVIAGMKEACEILNIPVTGGNVSFYNETGEKAIYPTPVIGMVGLIDDLETGLIPMAFQTEGDLIYLLGEPTGELGQSEFLKEFFGDVLVPVPPVDLQEGRRIIELLPLLKKQGLINSAHDVSDGGLAVSLCEAAFAGELGVNIDFTTSLLPQEFLFSEKVGLVIVSVSPEKEEEFIKSVKNAGVFVLKLGRVNGKDEIEICLNGQRVIQEKLSELKALYEGGLSWALK
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_STAAR
Sequence: MIYQKQRNTAETQLNISISDDQSPSHINTGVGFLNHMLTLFTFHSGLSLNIEAQGDIDVDDHHVTEDIGIVIGQLLLEMIKDKKHFVRYGTMYISMDETLARVVVDISGRPYLSFNATLSKEKVGTFDTELVEEFFRAVVINARLTTHIDLIRGGNTHHEIEAIFKAFSRALGIALTATDDQRVPSSKGVIE
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAAF1_DROPE
Sequence: MCEPGFARRREEVTGLNRITEKGLKDICKRDKLYQTPRLNDVLYLHFQGYQCIENLDEYTELKSLWLESNAISEIQNLTKLTKLKCLYLQNNLITKMENLEFNRELDTLNLSQNHIRKIENIGTDILPVLNTLNITSNYLTDSASLAALVECKTLSVLDLSNNRIDDILIVKIFEQMPSLKVLVLQGNPVVSRLPQYRKTLILACKELTYLDSRPVFPRDRACAEAWKREGYEGERKEVQRWNRAERRKTRESVNSTIRMRNRHLKPENQVPLLTSSDSEEEQKGISSAEKAQKRAEMEYGSVDTMWDEVSGESQASEHSTTSSTSAEDNESAGSQADHIAERISNRRVKPLEGRPKVLYDEAASGDVDSIVKLVTNKEENEQKDQNISEIEEQHKGKIVFIEEMNENQNASMGNQKAVSEAVETIGKPVAVDVNNTLSNSIVEPVNEQNNLASDQMEHLKGKRILIEKVDDIDPIKKELKYFDEAMQNKELKQTSELEELRDFTENLSSDVQEQAKDPSESDEEPTEEEMEVKSQLLKEQFQDRKQRLKEAIEERKTMQKNLEARKEDLNKSYNLFAKIMDDATDNVPKRVFGAGCDMPSKDWDKEECMQQLPLTSMEDSINGRPSSNDEDILTRPLTELTSAEAAEEICSQLDRKLAGEEAALRQLLCDLENENEILYSIETQIKYAESISVEDSQSQMVCASLLNDLISDVIYKDITEMGPNSYPLGPIESDEEYTYSEEPKLEKMVPPHLENPAGGKSLRECVDTFKEFFASKGNDKPRQESHTHLEKIRAAKALLKSKSLAEFSKDTPESLDAQLAKDEDRRKRHVAASAGRCFAKREKYDDTLEVVDNRLMVVKKDTGELEELPPPPELISDSESEKEVEEDDDAYDTAEETLQEYPRVPWTTPYKPKPRKAAEHLVNEAMQRILAEQFSELPDDTKENEPQEDEFFSLEAKETFGNLDSEFFQKLDLDKVTTANNAEAATECMRSYNELKACMKSGSTELQLTSEENEMLQEMLSSNEDLEAKHKSNDDPLVERDNELLNKMMQRMKEHEERARELQEQLEKEKEEENSGPIKLSMGEGSMLYQRWSPLSLTEIIDPQAEEGGRQAEEGGAQQEEGGAQSEERDDQAEGVPQAEEGVTQGEESVLQEEETHAENGVAQAEGRVLQSPEIYPIIGYEDIDDDDAASDFTTDYSSDDEVAVVVPPKISPAMLKAYYYDGFEEDMRMVRENEARTRRGLRAIMQKEKQMWKDNEEMAADMAPSPSPKEEHIPEVKTETETAKPTVETAKDKWAKIASRLNEFLDPEAMEQLESHEFGESDGEDDVDLTGLQNYDEESETECESALKETAEIGDSEKQENKTQDETLDPKDTEAITDVTLGIQRLKRQKLICQWEKIIPEDSKIGDGPTEKFLDQKAQDNPETTDERPENPKNFITLDYFVDTEPSESLEDTEATETPEVSTEQTLKTEQMEFNLDVLNDDGDVVIKEVTVEAQVTYQ
What is the function of this protein?
Cilium-specific protein required for cilia structures.
What are the official names of this protein?
Dynein axonemal assembly factor 1 homolog, Defective transmitter-recycling protein, Leucine-rich repeat-containing protein 50 homolog.
What is the protein family that this protein belongs to?
Belongs to the DNAAF1 family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: OLES_STRAT
Sequence: MKALVLAGGSGTRLRPITHTSAKQLVAVANKPVLFYGLEAIAAAGITDVGLIVGDTAGEVPRAVGDGAKFGLDITYIEQSRPLGLAHAVLIAHTYLGDDDFVMYLGDNFIVGGIDDLVRTFRDGRRPAARILLTHVSDPSGFGVAELDDDGRVVGLEEKPRHPKSDLALVGVYFFTPAIHEAVRAIEPSWRGELEITHAIQHLIDNGADIQSMVIEGYWKDTGNVADMLEVNRTVLEDLEPRIEGTVDEHTVVIGRVVVGEGARVTNSRIMGPAIIGAGPEISDSYIGPFTSVGDNCRITGSEMEFSIMLAESAITGVRRIEGSLIGRNVQVTQSLHAPNAHRFVLGDHSKVEIQS
What is the function of this protein?
Involved in the biosynthesis of the two 2,6-deoxysugars, dTDP-L-oleandrose and dTDP-D-desosamine, attached to the macrolactone ring oleandolide to produce the aglycone antibiotic oleandomycin (PubMed:10770761).  Catalyzes the formation of dTDP-glucose from deoxythymidine triphosphate (dTTP) and glucose 1-phosphate (By similarity).
What are the official names of this protein?
Glucose-1-phosphate thymidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glucose-1-phosphate thymidylyltransferase family.
Protein: PEN2_DROME
Sequence: MDISKAPNPRKLELCRKYFFAGFAFLPFVWAINVCWFFTEAFHKPPFSEQSQIKRYVIYSAVGTLFWLIVLTAWIIIFQTNRTAWGATADYMSFIIPLGSA
What is the function of this protein?
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch.  It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
What are the official names of this protein?
Gamma-secretase subunit pen-2, Presenilin enhancer protein 2.
What is the protein family that this protein belongs to?
Belongs to the PEN-2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: EFG_ACHLI
Sequence: MPRQYSLKMTRNIGIMAHIDAGKTTTTERILFHTGKIHKTGETHDGASQMDWMAQEQERGITITSAATTSVWRDHRVNIIDTPGHVDFTVEVSRSLRVLDGAVTVIDAQAGVEPQTETVWRQATEYKVPRIVYVNKMDKIGADFNNAIKTLHRRLGVKANAIQLPIGTELDFSGIIDLVTMTAVEYSGDALETTKEIPIPAHLEEQAIDMRNELIEAVAEFDDELMVTYLEGEEVSVELLKRAIRKGVLAVEFFPVVAGSSFKNKGVRKVLDAVIDYLPSPLDIPPVLGHTSEGVEVYRHADDEEPFTALAFKVMTDPFVGKLTFFRVYSGKIKSGSYVQNTTKGERERFGRILQMHANTRQEIDEVYAGDIAAAVGLKVTTTGNTLATQNDDIILESMNFPEPVIEVAVEPKTKNDQDKMGQALAKLAEEDPTFKTYTNTETGQTIIAGMGELHLDILVDRMKREFKVEANVTEPQVSYRETLTVPNEIEAKFIRQSGGRGQYGHVVIDFEPNPGKGFEFVDKIVGGVIPREYIPSVQKGLEEALGGGILAGFPVVDIKATLKFGSYHDVDSSEMAYKIAASMALKDAKNKANAVILEPIMDVEVVTPNDYVGNVIGDITSRRGRLESQEGRGNAISIRAFVPLSEMFGYATSLRSNTQGRATFVMQFDHFDKVPKSIQEEIIKKRGSN
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KV137_HUMAN
Sequence: MDMRVPAQLLGLLLLWVPGARCDIQLTQSPSSLSASVGDRVTITCRVSQGISSYLNWYRQKPGKVPKLLIYSASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYGQRTYNAP
What is the function of this protein?
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447).  Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Probable non-functional immunoglobulinn kappa variable 1-37.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: RS18_CUPNH
Sequence: MAFVKRDNKNKKRFQQQNPLFKRKRFCRFTVAGVEQIDYKDLDTLKDFIGDNGKITPARLTGTKAHYQRQLDTAIKRARFLALMPYTDLHKN
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: PTH_STRM5
Sequence: MAGLRLIVGLGNPGSEHARTRHNAGFHFVEALAEKAGARWNVDSKLFGETAKVEIAGQTVWLLKPATFMNLSGKSVTAAQRFWKIEPEETLLAHDELDLAPGVARLKFDGGHGGQNGLRDTIRLLGHGKFHRLRVGIGHPGHKDRVVGWVLGRPSKDDEVLISRAIDDAIDVLPLAVQGDFSEAMKRLHTPK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CATA1_ACILW
Sequence: MSIKVFGTKEVQDLLKAATNLEGKGGNARSKQIVHRLLSDLFKAIDDLDITPDEVWAGVNYLNKLGQDGEATLLAAGSGLEKYLDIRLDAADKAEGIEGGTPRTIEGPLYVAGATVHDGVSKIDINPDEDAGPLVIHGTVTGPDGKPVAGAVVECWHANSKGFYSHFDPTGAQSDFNLRGAVKTGADGKYEFRTLMPVGYGCPPQGATQQLLNVLGRHGNRPAHVHFFVSSDSARKLTTQFNIEGDPLIWDDFAYATREELIPPVTEKKGGTALGLKADTYKDIEFNLTLTSLVKGKDNQVVHRLRAEVAA
What is the function of this protein?
Can cleave 4-methyl-, 4-chloro-, and 3-methoxycatechol at lower rates than catechol, but has no activity with 4-nitrocatechol or protocatechuic acid.
What are the official names of this protein?
Catechol 1,2-dioxygenase 1, 1,2-CTD 1, CDI1.
What is the protein family that this protein belongs to?
Belongs to the intradiol ring-cleavage dioxygenase family.
Protein: PRT31_HYDCO
Sequence: ARRRHSMKKKRKSVRRRKTRKNQRKRKNSLGRSFKQHGFLKQPPRFRP
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine R3 isoform 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DXS_SALPB
Sequence: MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGNAQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.