PharMolix/UniProtQA huggingface dataset:
Protein: RTCA_AERPE
Sequence: MGSGEWVVVDGSMGEGGGQILRTAVALAAVLGRPLRIVNIRAKRRPPGLRPQHLTAVRAVAAISGGRLRGAEVGSTSLEFTPGRVRGGRYRFDVGTAGSVALIIQALAPLLAYSDSPVEVELTGGTDVPMAPTIDYMREVFASILAMLGYEIEIRVLRRGHYPRGGGRVVVRVPDPPGGFRARSFVERGPLKGVYVRSHAVKLPGSIAERQARSAASLVRERLGVDPIVEIEAYKPHRDPHLGPGTGVLVWAVFGETVMGGDSIGKKGKPAEVVGREAAESLLEDMATGAALDRHMSDMAPVYLALAGGVSTVFGARLTGHASTILELLRIMVDGFEYRILEGGLERPFKAELRGAGVSPR
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPSR1_HUMAN
Sequence: MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
What is the function of this protein?
G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440).  Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440).  Inhibits cell growth in response to NPS binding (PubMed:15947423).  Involved in pathogenesis of asthma and other IgE-mediated diseases.
What are the official names of this protein?
Neuropeptide S receptor, G-protein coupled receptor 154, G-protein coupled receptor PGR14, G-protein coupled receptor for asthma susceptibility.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 9]: Cytoplasm.
Protein: GSTT1_LUCCU
Sequence: MDFYYLPGSAPCRSVLMTAKALGIELNKKLLNLQAGEHLKPEFLKINPQHTIPTLVDGDFALWESRAIMVYLVEKYGKNDSLFPKCPKKRAVINQRLYFDMGTLYKSFADYYYPQIFAKAPADPELYKKMEAAFDFLNTFLEGHQYVAGDSLTVADLALLASVSTFEVAGFDFSKYANVAKWYANAKTVAPGFDENWEGCLEFKKFFN
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase 1-1, GST class-theta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
Protein: RSMH_STRP3
Sequence: MTKEFHHVTVLLHETVDMLDIKPDGIYVDATLGGSGHSAYLLSKLGEEGHLYCFDQDQKAIDNAQVTLKSYIDKGQVTFIKDNFRHLKARLTALGVDEIDGILYDLGVSSPQLDERERGFSYKQDAPLDMRMDRQSLLTAYEVVNTYPFNDLVKIFFKYGEDKFSKQIARKIEQARAIKPIETTTELAELIKAAKPAKELKKKGHPAKQIFQAIRIEVNDELGAADESIQDAMELLALDGRISVITFHSLEDRLTKQLFKEASTVDVPKGLPLIPEDMKPKFELVSRKPILPSHSELTANKRAHSAKLRVAKKIRK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPKC_NEOFI
Sequence: MAEFVRAEILGTKFEYTTRYVNPQPIGMGSFGLVCSAFDQITQQPVALKKIMKPFDSSSLAKRTYREIRLLKYLRHENLICLRDIFISPLEDIYIATELLGTDLGRLLSIKPLDSKFSQYFIYQILRGLKYIHSANVIHRDLKPTNILINENCDLKICDFGLARLQEPQMTGYVATRYYRAPEIMLTWQRYGVQVDVWSAGCILAEMLRGKPLFPGKDHVHQFHLITNVLGNPPDAVIEKITSKNTVNFVKSLPSREPRDLSTVIMTHTSIAIDLLKKMLVIDPDTRISAQDALRHPYLAPYHDPTDEPAASGPFDWSFDSADFPKETWKIMIYSEVLDYLNVGNPADPAPFDPSTPFDPSALEREFSEFLSDSGQI
What is the function of this protein?
Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.
What are the official names of this protein?
Mitogen-activated protein kinase mpkC, MAP kinase C.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
Protein: YCIO_ECOLI
Sequence: MSQFFYIHPDNPQQRLINQAVEIVRKGGVIVYPTDSGYALGCKIEDKNAMERICRIRQLPDGHNFTLMCRDLSELSTYSFVDNVAFRLMKNNTPGNYTFILKGTKEVPRRLLQEKRKTIGMRVPSNPIAQALLEALGEPMLSTSLMLPGSEFTESDPEEIKDRLEKQVDLIIHGGYLGQKPTTVIDLTDDTPVVVREGVGDVKPFL
What are the official names of this protein?
Uncharacterized protein YciO.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family.
Protein: DEOC_ALIF1
Sequence: MSDLKAAALRALKLMDLTTLNDNDTDEAVIALCKNAKTAVGNTAAVCIYPRFIPIAKKTLREQGTPEVRIATVTNFPHGNDDIEIAVAETKAAVAYGADEVDVVFPYRALIAGDETTGFELVKQCKEACGDVLLKVIIETGELKEEALIKKASQICIEAGANFIKTSTGKVPVNATPEYARMMLEVIRDMDVAKTVGFKPAGGVRTAEDAQAYLAMADDILGGDWADNMHYRFGASSLLTNLLNTLEVTEETADPSAY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_ACTP7
Sequence: MFTANMNIQDYDPILWQAIENENRRQEEHIELIASENYASPRVMQAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAIDRAKQLFGADYVNVQPHSGSQANAAVYGALIQPNDTILGMDLAHGGHLTHGAKVSFSGKIYNSVLYGITAEGLIDYEDVRQKALECKPKMIVAGFSAYSQIVDWAKMREIADEVGAYLFVDMAHVAGLIAAGVYPSPLPYAHVVTTTTHKTLGGPRGGLILSACGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKEALEPEYKIYQQNVVKNAKAMVEVFKQRGYEVISNGTENHLFLVSFVKQGLTGKAADAALGQANITVNKNSVPNDPQKPFITSGIRIGTPAVTRRGFKEADVQALAGWMCDVLDSIGKDNHEQVIAETKAKVLDICARLPVYAK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EGLB_EMENI
Sequence: MKVNTLLVAVAAGTAMAAPQLKKRAGFTFFGVTEAGAEFGEKSIPGVWGTDYTFPDTESILTLISKGFNTFRIPFLMERLTPEMTGSFDEGYLKNLTSVVNAVTDAGAWAIVDAQNFGRFNGEIISSASDFQTWWKNVAAEFADNKNVIFDTNNEFHDMDQTLVLDLNQAAINGIRAAGATSQYIFVEGNSYTGAWTWTDNNDNLKSLTDPQDKIVYEMHQYLDTDGSGTHETCVSETIGAERVESATQWLKDNGKLGVIGEFAGGNNEICRAAVKSLLDALKENDDVWLGALWWAAGPWWEDYMFSMEPTDGIAYTGMLSTLEAYMN
What is the function of this protein?
Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan.  Involved in the degradation of complex natural cellulosic substrates.
What are the official names of this protein?
Endo-beta-1,4-glucanase B, Endoglucanase B, Carboxymethylcellulase B, Cellulase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYY_BACVZ
Sequence: MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADSLHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTQDIVVEWSQKIKNQLSRFLDFEAGENPAVIANNFDWIGKLSIIEFLRDVGKNFGINYMLAKDTVSSRIETGISYTEFSYMILQSYDFLNLYREKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAFGLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLSKEEIEAYAEKTETAPEKREAQKRLAEEVTVLVHGREALEQAVHISQALFSGNIKELSAQDVKVGFKDVPSFEKDRSEELSLVDVLVESKLSPSKRQAREDIQNGAVYINGERQTDIGHLLTAEDRIEDQFTVLRRGKKKYFLITY
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUXS_SHESH
Sequence: MPLLDSFTVDHTRMQAPAVRIAKTMKTPKGDVITVFDLRFCVPNKEILSERGIHTLEHLYAGFMRDHLNGDSVEIIDISPMGCRTGFYMSLIGTPAEADVAQAWLASMNDVLKVAEQAQIPELNEYQCGTFDMHSLDQAQSIARSIIAAGITVNKNDELKLSDEILNGL
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: MSRB_ERWT9
Sequence: MAKQDNSSSHENTLTEMQRYVTQEHGTEPPYSGKLLHNKDEGIYHCLICRAPLFLSDSKYDSGCGWPSFYQPFSPEAIRYLEDDSHGMQRVEIRCGSCDAHLGHVFPDGPQPTGERFCVNSASLSFTDDNGNKTLG
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: TAL_OPITP
Sequence: MPTNQLEQLKQFTTVVADSSDFDSMKSYQPRDATTNPSLILKAAGMPDYGHLVEKAITDAGSGASPAAVIDLLLVLFGAEILKIVPGRVSTEVDARLSFDRVGSMEKARTLIALYEKQGVPRERILIKLASTWEGIRAAEKLQQEGINCNMTLLFSFPQAVAAAKAKVKLISPFVGRILDWYKKSTGQDYAPADDPGVNSVREIYTYYKRFGYETEVMGASFRNKDEILELAGCDLLTIAPKLLGELAASTDPVERKLEPEAARKAKVKRVSFDEKSFRWALNEDQMATEKLSDGIRSFAADVRKLEQLIQQQRG
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPP2_ASPFC
Sequence: MRGSGRSDIVISAVDALDICITLARNDCDKYPGSVAAKLGVSSGLIYLVGQPTINWGDSDQPRPFRQRRYFYYLSGVEEADCYLTYDIKNDLLTLYVPDFDLHRAIWMGPTLTVKEARERYDVDQVRYHASLKGDIQRWADNYNKTSLLYILHDTQKPQVLSNELRLDDELLLPAMDAARGIKDEHEIRMIREANRVSALAHRKVLENVLRMSTEAEIEGLFLDTCISHGAKNQAYEIIAGSGENAAVLHYVKNNEPLQGRQLVCLDAGAEWNCYASDVTRTFPLAADWPTARARDIYQLVEEMQEECIKRIQKGVRFLDLQVLAHVIAIEGLMRLGILKGGSVEEIRESGASTVFFPHGLGHHVGLEVHDVSAKRLTAVEGDKEYYSSILVPSMSHCPCTLSAPLLEEGMVVTVEPGIYFSRLALANARKLAFAKYINFDEAEKYIPIGGVRIEDDILVTSSGHENLTTAPKGEEMLEIIRRGIDS
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase AFUB_014460, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: TI214_CUSEX
Sequence: MEKKTNKNKGVAEETKKKVAATTGFIIGQFIRFISIYYAPLYVALGRPHTITILALPYLLIHLFWNTDKSFFAYDSKKLNSIRNLEISSVFLNHFILQLLNSCILPNSTLARLITIYMFRCNNKILFLTSSFFAWFIGQIFMLNSFELVLVWIRKKNYLRSTFRNYLLRNSIFVILFNCLFGSLLFILSIQCLGRIPSPIPTQKLSEVSKIEQRERERLQSEEERDVEKKKPDYKLPDSESEILQKNESETPEFEKHLAALLFDYKRWTRPFRYIKNNRLEQALRNELSQYFFDTYQSDGKNRLSFTHPISLSTFLKMMKLKIPLLLVEKTLYNPLDNGWVSRNKKQMNYRRIYFLNRVNNLDKAVALPRIQFETTRTRLCIHNDETKQEYLPENYDPLLTGPHRGRIKRGLLTINDTLTINDTLSEHLRETIILNRLHALVLLNTNSKNFNQKMYTFEKKPLEISDFSTLSSNLNLTDPDQKTEFLVNPIETHDPNFIRKYIPIEEIRKNAPRWSYKLITELEQISYYKNPPEDHDIRSRKGISVVIFDPTKEAATTNSKTNTTKDTNLETKNKSKSDEKLVVIRYPQQSDFRQGLIKDSMRTQRRKIFLQELFNANVHSPLFFDRLRIVFSFPRLKQIFINLSARHVFGILKSTDKQTKRKRTKKEEKGENKRREQKERLEIGEAWDVFPLAQIIRGLLLLTQSFIRKKIILPSLILGKNIGRILLCQIPEWSEDLQEWNRETHIKCTYNGIPLSQKKFPENWLTEGIQIKILFPFCLKPWHAYKPRTSHYDFCFLTVWGRETEQPFGHPRKTPFFFEPVLQELDKKIVNIKARIFSKVKINLFKRVSKENDFQIRKQIMNESFRQIEEIPSCTNSSLIEKMRNMSDRTRTIKKKIERMTEDKKKVTLELYISTYKRSYRLALSKTICKMVKVLIWKFSYFQKLLNQRVYNDIFLYTIYICRMTTQLFLESTKKFISKSILKNERTKKRININKETKNKIHFLSKLKTSKNCKKNLDLSCDFSNLSQAYVFYKISQTGVLNICKLISVLQHTVISFFIQTQIKDLVHTEGIFKSEVIHQKLQWPKTSQWKNWLRLNSKYDLSPIFWFSLISQKQKWRNRVTKYHRPKEKYLNKWNSHGKYRLSDYKKQNVPKSVSNQKDNSKKCYQYDLLSYKSINYEKKSASVLYRSTPKVTKGQAIYHNDNMSQNYLFAITPNIPGKIKRVDIPYIGKNLDRKYLIWKNIHFSLRKKVDIESWVAVNTSSNKDSTIGNYNYQLIDQIDKKEKELFSLPIHQNTEINRPNSTNSLVDWMGMNEQILNRPITNLELWFFPEFVWLFNVYKTKPWIIPSKILLLNSNLSEIDSQQKSETDSETDSQQKNIAETQKYLEEDSTKSDTKKETELELELFTKKYFLFQLRGDQTFNKSFFKNIQIYCLLLRLRNRKKMTLSCIQRRKLNLRIMPSMTNLLNVPEFLKRTGLVMDPLPLSIKTDGKFLLYKIVGISLVHKSKDQTNKKYRKTRIIRAVENNHLDVLVLENILSSRCRRELRTLICFNYKNWNGVNTTSIFCSKNCNLFWEERNPRQNDKRELIQKFIWPNYRLEDLACMNRYSFDTTNGSRFSILRFHMYLPRKIHG
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: ATG12_YARLI
Sequence: MIESDSDTSDDAPQEYVSASANIPAQFELATAHMKATPEPQPTQQPDAEALHDDDPLTTTQDHPTGPSATASDTIDSTPQPMAPATLSASAVLPSLPSDTAALLETFSQQLQQSNVKCQLKFRPIGGATPSLKQSVYKIAETQQFGVVVKFLRKQLKIKNSQSSQIFCYISSFAPGLDETVGSLYNRYAIRGELTISYCLNQAFG
What is the function of this protein?
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.  Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function.  The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
What are the official names of this protein?
Ubiquitin-like protein ATG12, Autophagy-related protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG12 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: ERCC8_MOUSE
Sequence: MLSFLSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERIHGSGVNTLDIEPVEGRYMLSGGSDGVVVLYDLENASRQPHYTCKAVCSVGRSHPDVHKYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRRASGCLLTLDQHNGKKSQAAESANTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGDNTLVNYGKVCNDSRKGLQFAVSCGCSSEFVFVPHGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAWVPPSYEPVPDDDDEAPAKSQLNPAFADAWSSSDEDG
What is the function of this protein?
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (By similarity).  The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair (By similarity).  It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (By similarity).  Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ) (By similarity).
What are the official names of this protein?
DNA excision repair protein ERCC-8, Cockayne syndrome WD repeat protein CSA homolog.
What are the subcellular locations of this protein?
Nucleus. Nucleus matrix. Note=UV-induced translocation to the nuclear matrix is dependent on ERCC6.
Protein: COBS_CLOK1
Sequence: MKELLNDFFLILQLLTRIPVNRNLLCRRENFRRGASFMPLVGVIVGGIQWIIYKLCIIIFSLNVSIVIVILAGIVLTGALHVDGLGDMCDGFFSFKEKGKIIEIMKDSRIGTYACLAIIIDILLKYSFFCSIVPSFSLIIIIAPVMSRFSIVFIAFIGKPAKSTGSGNLFVENIGKWQLFWAAFITVITLFFLMNMNFIYVIILIFAGLFMSFLFNVFCNRKAGGLTGDLLGANNEIVEILTMVMLCVIITK
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KRR1_YEAS8
Sequence: MVSTHNRDKPWDTDDIDKWKIEEFKEEDNASGQPFAEESSFMTLFPKYRESYLKTIWNDVTRALDKHNIACVLDLVEGSMTVKTTRKTYDPAIILKARDLIKLLARSVPFPQAVKILQDDMACDVIKIGNFVTNKERFVKRRQRLVGPNGNTLKALELLTKCYILVQGNTVSAMGPFKGLKEVRRVVEDCMKNIHPIYHIKELMIKRELAKRPELANEDWSRFLPMFKKRNVARKKPKKIRNVEKKVYTPFPPAQLPRKVDLEIESGEYFLSKREKQMKKLNEQKEKQMEREIERQEERAKDFIAPEEEAYKPNQN
What is the function of this protein?
Required for 40S ribosome biogenesis.  Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.  Essential for vegetative growth (By similarity).
What are the official names of this protein?
KRR1 small subunit processome component, KRR-R motif-containing protein 1, Ribosomal RNA assembly protein KRR1.
What is the protein family that this protein belongs to?
Belongs to the KRR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: Y621_METJA
Sequence: MKACERLLLKIESQEKFVEEFKRILLELGLTLKEFSEISGIPYSTLYKVIQGKDFRVSTLIKILKTIRSFEKDENIDTIAIIAARPALNKITTRKIGINGKSYLIKEYPANSLEECIVAAVRAEREGVKGIVCAPIVSATIEKIVNVPVAVIIPEKDAFMKALEIIAKKINE
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator MJ0621.
Protein: MGSA_THETR
Sequence: MVNLNIALIAHDMKKSLMIDFAIAYKDILEKCNIYATGATGQLVEEATGIKVNKFLPGPMGGDQQIGAMIAEDKMDLVIFLRDPLTAQPHEPDILALLRVCDVHSIPLATNLATAEVLIKGLDAGLLEWRNAVK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: REP2_MDV1
Sequence: MASKRWCFTLNYKTALERETFISLFSRDELNYFVCGDEIAPTTGQKHLQGYVSMKKLIRLGGLKKKFGSIAHWEIAKGDDFQNRDYCTKETLIAEIGAPVKKGSNRRKIMEIYEEDPEEMKLRDPDTALRCKAKKLREEYCSEVSVFSLRPWQIELHRALMEVPDDRTIIWAYGPDGGEGKSTFAKELIKYGWFYTAGGKTQDILYMYAQDPERNIAFDVPRCSSEMMNYQAMEMMKNRVFASTKYRPVDLCIRKKVHLIVFANVAPDPTKLSEDRIVIINC
What is the function of this protein?
Initiates and terminates the replication only of its own subviral DNA molecule.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific hairpin at the genome origin of replication.  Introduces an endonucleolytic nick within the intergenic region of the genome, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities (By similarity).
What are the official names of this protein?
Para-Rep C2, Rep2, Replication-associated protein of non-essential DNA C2.
What is the protein family that this protein belongs to?
Belongs to the nanoviridea/circoviridae replication-associated protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: SYY_LISMC
Sequence: MNIIDELEWRGAIYQQTDEEGLRKWVEEKQISLYCGIDPSGDSMHIGHLIPFMILRRFQNAGHRPIILVGGATGTIGDPSGKKEERKLQSMEQISKNVESLRVQLGKIFDFEGNSAASMVNNYDWTKDVSILDFLRDYGKEFNVNTMLSKDIVASRLEVGISFTEFAYQILQAMDFNHLYEFNDCRLQIGGSDQWGNITAGLDLIRKKQGENAKAFGLTIPLLTKADGTKFGKSEGGAIWLNPEKTTPYEFYQFWINTDDRDVVKYLKYFTFLTEAEIDELAKQVETEPHLRAAQKTLAAEMTKFVHSEEALEQALKISKALFSGDVKALTADEIEQGFKDVPTFVAEDTEANLVDWLVTLGIEPSKRQAREDVGNGAIYINGERQQDLEKIMDASDRIENKFTIVRRGKKKYFLVSYK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_RHIOR
Sequence: MNTYKPYSERAKQHSNACARSLLELMERKQTNLSVAVDVTTKKELISIADAIGPYICVLKTHIDIVEDFDADLIQQLQELAKKHDFLFFEDRKFADIGNTVKHQYANGIYKIASWSHITNAHTVPGEGIIKGLAEVGLPLGRGLLLLAEMSSKGALTKGSYTTDSVEMARRNKDFVFGFIAQNKMNQYDDEDFIVMSPGVGLDVKGDGLGQQYRTPREVIVESGADVIIVGRGIYGQPDKLVEQAQRYRQAGWDAYLERLALHNK
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase, Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family.
Protein: TECT2_HUMAN
Sequence: MGFQPPAALLLRLFLLQGILRLLWGDLAFIPPFIRMSGPAVSASLVGDTEGVTVSLAVLQDEAGILPIPTCGVLNNETEDWSVTVIPGAKVLEVTVRWKRGLDWCSSNETDSFSESPCILQTLLVSASHNSSCSAHLLIQVEIYANSSLTHNASENVTVIPNQVYQPLGPCPCNLTAGACDVRCCCDQECSSNLTTLFRRSCFTGVFGGDVNPPFDQLCSAGTTTRGVPDWFPFLCVQSPLANTPFLGYFYHGAVSPKQDSSFEVYVDTDAKDFADFGYKQGDPIMTVKKAYFTIPQVSLAGQCMQNAPVAFLHNFDVKCVTNLELYQERDGIINAKIKNVALGGIVTPKVIYEEATDLDKFITNTETPLNNGSTPRIVNVEEHYIFKWNNNTISEINVKIFRAEINAHQKGIMTQRFVVKFLSYNSGNEEELSGNPGYQLGKPVRALNINRMNNVTTLHLWQSAGRGLCTSATFKPILFGENVLSGCLLEVGINENCTQLRENAVERLDSLIQATHVAMRGNSDYADLSDGWLEIIRVDAPDPGADPLASSVNGMCLDIPAHLSIRILISDAGAVEGITQQEILGVETRFSSVNWQYQCGLTCEHKADLLPISASVQFIKIPAQLPHPLTRFQINYTEYDCNRNEVCWPQLLYPWTQYYQGELHSQCVAKGLLLLLFLTLALFLSNPWTRICKAYS
What is the function of this protein?
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.  Required for hedgehog signaling transduction (By similarity).
What are the official names of this protein?
Tectonic-2.
What is the protein family that this protein belongs to?
Belongs to the tectonic family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.