PharMolix/UniProtQA huggingface dataset:
Protein: RL14_WIGBR
Sequence: MIQVQTILSVADNSGARLVMCIKVLGGSRRRYAKISDIIKIAVKEAIPRAKVKKGEVLKAVIVRTKKNLHRSDGSVLRFDKNACVLLNDSTEQPIGTRIFGPVTRELRTEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ACP_HALH5
Sequence: MADTLSRITKIVVDRLGVDEAEVKPEASFKDDLGADSLDVVELVMELEDEFDLEISDEEAEKIATVADVVEYIEGRQ
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
Protein: RRF_STRPJ
Sequence: MANVIIEKAKERMTQSHQSLAREFGGIRAGRANASLLDRVHVEYYGVETPLNQIASITIPEARVLLVTPFDKSSLKDIERALNASDLGITPANDGSVIRLVIPALTEETRRDLAKEVKKVGENAKVAVRNIRRDAMDEAKKQEKAKEITEDELKTLEKDIQKVTDDAVKHIDDMTANKEKELLEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBI_SYNJA
Sequence: MLLLKISVYAVVIFFVGLFVFGFLSNDPARNPNRRDME
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.4 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: NIFW_FRACC
Sequence: MSVSMAAGQLADFRRCSTAEEYFILLDVDYDPRVLAVNRLHILRYFANQLVELHDTRTEAGNPVELLREYRDALIRSYEAFTTASALDHRLFKVLQDRAPQSSFVPASSITVERLTPTVPQPSAPSDPVEPSQSAWPHHAAASADYLGGTR
What is the function of this protein?
May protect the nitrogenase Fe-Mo protein from oxidative damage.
What are the official names of this protein?
Nitrogenase-stabilizing/protective protein NifW.
What is the protein family that this protein belongs to?
Belongs to the NifW family.
Protein: ZC3H1_HUMAN
Sequence: MATADTPAPASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPPHSARGGGSGGGGGSSSSSSSSQQQLRNFSRSRHASERGHLRGPSSYRPKEPFRSHPPSVRMPSSSLSESSPRPSFWERSHLALDRFRFRGRPYRGGSRWSRGRGVGERGGKPGCRPPLGGGAGSGFSSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKNENCVEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSITKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGAKPLSLKSDTTDSSQGLQDKEQNLTRRISTSDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGGGIYQYDNYEEVAMDTDSETSSPAPSPVQPPFFSECSLGYFSPAPSLSLPPPPQVSSLPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSHPVPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIAMVTKQVTDAESKLKKHRILLMKDESVLKNLVQQEAKKKESVRNAEAKITKLTEQLQATEKILNVNRMFLKKLQEQIHRVQQRVTIKKALTLKYGEELARAKAVASKEIGKRKLEQDRFGPNKMMRLDSSPVSSPRKHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNISPVVEEEPEFSLPQPSLHDLTQDKLTLDTEENDVDDEILSGSSRERRRSFLESNYFTKPNLKHTDTANKECINKLNKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGITEKVLHGQEISVDVDFVTAQSKTMEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHIQDYTLSRKQLFQDILSYNLSLIGCAETSTNEEITASAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISDNSFSSDEEQSTGPIKYAFQPENQINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGECSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKDEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMLEFLMGAAKQETSNILSFQLLEALLFRVQLHIFTGRCQSALAILQNALKSANDGIVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNDNPSRIVNTESFVMPWQAVQDVKTNPDMLLAVFEDAVKACTDESLAVEERIEACLPLYTNMIALHQLLERYEAAMELCKSLLESCPINCQLLEALVALYLQTNQHDKARAVWLTAFEKNPQNAEVFYHMCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYNNLDLFRYLLNIPGPIDIPSRLCKGNFDDDMFNHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRCDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTLERFCSVMPANSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLNSNKTESKNH
What is the function of this protein?
Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation.  The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei.  Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.
What are the official names of this protein?
Zinc finger C3H1 domain-containing protein, Coiled-coil domain-containing protein 131, Proline/serine-rich coiled-coil protein 2.
What are the subcellular locations of this protein?
Nucleus. Note=Excluded from the nucleolus.
Protein: NANM_ECOL5
Sequence: MNKTITALTIIMASFATNASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLDTQAKDKKWTALAAFPGGPRDQATSAFIDGNLYVFGGIGKNSEGLTQVFNDVHKYNPKTNSWVKLMSHAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDLNEAGKDSTTIDKINAHYFDKKAEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFELDFTGNNLKWNKLAPVASPDGVAGGFAGMSNDSLIFAGGAGFKGSRENYQNGKNYAHEGLKKSYSADIHLWHNGKWDKSGELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLISVKDNKVTVQN
What is the function of this protein?
Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers.  Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer.  In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
What are the official names of this protein?
N-acetylneuraminate epimerase, N-acetylneuraminate mutarotase, Neu5Ac mutarotase, Sialic acid epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanM family.
What are the subcellular locations of this protein?
Periplasm.
Protein: EFP_PERMH
Sequence: MGVKIGINQIKKDMFIVHDGQPYRVLDYDHVKPGKGQAFVRVKAKNMKTGNVIEITYKSSESIELADFEQRQMSYSYFDGDSYWFIDMNTGDMIAVPASVLGDEAQFLKEGMEVFIFLDKGQPIGVELPKSAVYEVIETEPGFKGDTATSTLKPAKIDTGATVQVPLFINEGDKIKIDTRTGKYIERVNE
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHFL_RAT
Sequence: MAQDGVELEKSVRRLREKFHGKVSPKKAGALMRKFGSDHTGVGRSIVYGVKQKDGQELSNDLDAQDPPEDMKQDQDIQAVATSLLPLTQANLRMFQRAQDDLIPAVDRQFACSSCDHVWWRRVPQRKEVSRCRKCRKRYEPVPNDKMWGLAEFHCPKCRHNFR
What is the function of this protein?
Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes.  Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site.  May exhibit antiviral activity.
What are the official names of this protein?
Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog, SHFL, Repressor of yield of DENV protein homolog, RyDEN.
What is the protein family that this protein belongs to?
Belongs to the SHFL family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly found in t for dsDNA.
Protein: GPH_AQUAE
Sequence: MRVILFDLDGTLIDSAKDIALALEKTLKELGLEEYYPDNVTKYIGGGVRALLEKVLKDKFREEYVEVFRKHYLENPVVYTKPYPEIPYTLEALKSKGFKLAVVSNKLEELSKKILDILNLSGYFDLIVGGDTFGEKKPSPTPVLKTLEILGEEPEKALIVGDTDADIEAGKRAGTKTALALWGYVKLNSQIPDFTLSRPSDLVKLMDNHIVEF
What is the function of this protein?
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: LYTM_STAAS
Sequence: MKKLTAAAIATMGFATFTMAHQADAAETTNTQQAHTQMSTQSQDVSYGTYYTIDSNGDYHHTPDGNWNQAMFDNKEYSYTFVDAQGHTHYFYNCYPKNANANGSGQTYVNPAIAGDNNDYTASQSQQHINQYGYQSNVGPDASYYSHSNNNQAYNSHDGNGKVNYPNGTSNQNGGLASKATASGHAKDASWLTSRKQLQPYGQYHGGGAHYGVDYAMPENSPVYSLTDGTVVQAGWSNYGGGNQVTIKEANSNNYQWYMHNNRLTVSAGDKVKAGDQIAYSGSTGNSTAPHVHFQRMSGGIGNQYAVDPTSYLQSR
What is the function of this protein?
Peptidoglycan hydrolase (autolysin) specifically acting on polyglycine interpeptide bridges of the cell wall peptidoglycan.
What are the official names of this protein?
Glycyl-glycine endopeptidase LytM, Autolysin LytM.
What is the protein family that this protein belongs to?
Belongs to the peptidase M23B family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYM1_YEAST
Sequence: MKLLHLYEASLKRRPKTTNAIMTGALFGIGDVSAQLLFPTSKVNKGYDYKRTARAVIYGSLIFSFIGDKWYKILNNKIYMRNRPQYHWSNMVLRVAVDQLAFAPLGLPFYFTCMSIMEGRSFDVAKLKIKEQWWPTLLTNWAVWPLFQAINFSVVPLQHRLLAVNVVAIFWNTYLSYKNSKVMEKDKVPVHYPPVVE
What is the function of this protein?
May be involved in cellular response to stress.  Required to maintain mitochondrial DNA (mtDNA) integrity and stability.  Required for ethanol metabolism and tolerance during heat shock.
What are the official names of this protein?
Protein SYM1, Stress-inducible yeast MPV17 protein 1.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal membrane protein PXMP2/4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TX3_LOXIN
Sequence: MTFKLFVVVTLVLAIYVATAEEAMKDDSEPAERGCIKYGDRCGSPHGLPSNCCNDWKYKGRCGCTMGVCTCGPNCPSRGCDWSKKG
What is the function of this protein?
Toxin active against S. frugiperda larvae.  May act on sodium channels (Nav).
What are the official names of this protein?
U2-sicaritoxin-Li1a, U2-SCRTX-Li1a, LiTx3, Toxin 3.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 39 family.
What are the subcellular locations of this protein?
Secreted.
Protein: THIG_BACC7
Sequence: MLNIGPFSFHSRLLLGTGKFPDFDVQQKAIDVSEAEILTFAVRRMDIFDAKQPNLLERLDVKKYTLLPNTAGAKNAEEAVRIAKLAKASGLCDMIKVEVIGDDRTLLPDPVETLKASEMLLEEGFIVLPYTSDDVVLARKLQELGVHAIMPGASPIGSGLGIVNPLNLSFIIEQATLPVIVDAGIGSPADAAFAMELGADGVLLNTAVSGAKDPIKMAQAMKLSIEAGRLGFEAGRIARKRCATASSPLEGMSVVE
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_BRUSU
Sequence: MMESGEALLKKLDGRLSGLRGRLTPDTGMDKITWFRAGGPAQVLFQPSDEEDLSAFLKAVPEEIPLLVVGIGSNLLVRDGGVPGFVVRLSAKGFGEVEQVCDTQLRAGAAAPDKRVAAAALEAGLAGFHFYHGIPGGVGGALRMNAGANGVETRERVVEVRALDRKGEVHVLSNADMGYAYRHSSASPDLIFTSVLFEGVPGERDDIRRAMDEVQHHRETVQPVREKTGGSTFKNPEGTSAWKEIDKAGCRGLRVGGAQMSEMHCNFMINTGNATGHDLETLGETVRARVFENSGIRLHWEIKRLGLFREGEQIEEFLGKII
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_SCHPO
Sequence: MNRSAALSILKRQSSTAASSSLKRTPLYDLHLKEGATIVPFAGFSMPVQYKGQTISASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSLKELKPFHSTLSAFTNETGGIIDDTIISKQDENTYYIVTNAACSEKDEANLKKHIENWKGVELERVQGRALIAIQGPETASVVQKLIPNVDFSVLKFGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLADTRVRPIGLGARDTLRLEAGMCLYGSDIDDTTSPVEGSLSWIIGKRRRKEGGFVGSSRILKELKDGPSRRRVGFIVEKVPARHGSAVEVDGVEVGQVTSGCPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFVETHYYK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Probable aminomethyltransferase, mitochondrial, Glycine cleavage system T protein, GCVT.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CWC27_PONAB
Sequence: MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGSGGESIYGAPFKDEFHSRLRFNRRGLVAMANAGSHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLSEVDIDDEERPHNPHKIKSCEVLFNPFDDIIPREIKRPKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPVVESEKGDAAGDLDDGGEGESAEHDEYIDGDEKNLMRERIAKKLKKDTSANVKSTGEGEVEKKSVNRSEELRKEARQLKRELLAAKQKKVENAAKPAEKRSEEEEATPDGAVAEYRREKQKYEALRKQQSKKGTSREDQTLALLNQFKSKLTQAIAETPENDIPETEVEDDEGWMSHVLQFEDKSRKVKDASMQDSDTFEIYDPRNPVNKRRREESKKLMREKKERR
What is the function of this protein?
As part of the spliceosome, plays a role in pre-mRNA splicing.  Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
What are the official names of this protein?
Spliceosome-associated protein CWC27 homolog, Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog, PPIase CWC27.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NEP_PONAB
Sequence: MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATAEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGEPLLKLLPDVYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYKKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
What is the function of this protein?
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids.  Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond.  Catalyzes cleavage of bradykinin, substance P and neurotensin peptides.  Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9.  Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)).  Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
What are the official names of this protein?
Neprilysin, Atriopeptidase, Enkephalinase, Neutral endopeptidase 24.11, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE.
What is the protein family that this protein belongs to?
Belongs to the peptidase M13 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: ZN586_HUMAN
Sequence: MAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEAQRCLYRDVMLETLTLISSLGCWHGGEDEAAPSKQSTCIHIYKDQGGHSGERPYECGEYRKLFKNKSCLTEPRRDHKHRNVRTGERPYECSKYGKLFHQKPTLHIHERFHTGQKTYECSECGKSFHQSSSLLQRQTLHTRERPYECIECGKAFAEKSSLINHRKVHSGAKRYECNECGKSFAYTSSLIKHRRIHTGERPYECSECGRSFAENSSLIKHLRVHTGERPYECVECGKSFRRSSSLLQHQRVHTRERPYECSECGKSFSLRSNLIHHQRVHTGERHECGQCGKSFSRKSSLIIHLRVHTGERPYECSDCGKSFAENSSLIKHLRVHTGERPYECIDCGKSFRHSSSFRRHQRVHTGMRPYK
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 586.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIMB_RHOER
Sequence: MTDDFGRVDFGAFLAPWHRADSDANFAIHQDLELVEHLDRLGFAEFWLGEHHSGGVEIVASPEMFMAAAAQRTQRIKLGLGVVSLPYHHPFLVADRLVLLDHLSRGRMIFGAGPGQLADDAKMLGIDPIDSRRKMEEAFDVIHRLLAGETVTQKTDWFTCQDAYLHVAPYSNIQKAVTATVSPTGPKLAGKYGSGILSLAATNPVGVEKLAEHWKIAEDIAAENGQTVDRADWRLSGIMHVAETEEQARADVRHGLLYLMNYLSNITPGFAAAPDVDSLIDGINDAGLAVIGTPEMAVTQIRRLQEKSGGFGKFLVLHGEWASTTAALHSFELIAQQVAPHFNGDLGPRLRGYNQTMNSNRSAADITQAAQEEAQKRFEAERAIRTN
What is the function of this protein?
Acts on both enantiomers of limonene by their NAD-dependent epoxidation at the 1,2 double bond forming limonene-1,2-epoxide.
What are the official names of this protein?
Limonene 1,2-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the bacterial luciferase oxidoreductase family.
Protein: TRML1_MOUSE
Sequence: MDCYLLLLLLLLGLAGQGSADSHPEVLQAPVGSSILVQCHYRLQDVRALKVWCQFLQEGCHPLVTSAVDRRAPGNGRIFLTDLGGGLLQVEMVTLQEEDTGEYGCVVEGAAGPQTLHRVSLLVLPPVPGPREGEEAEDEKETYRIGTGSLLEDPSLDPSASAGPHEFRRRENSIPLIWGAVLLLALVVVAVVIFAVMARKKGNRLVVCGPSQSTGVPGMDPPSAAHRSSDSGLPSDIPHVRLDSPPSFDSIYTGSSLDPPSSEPPAPPSQPPLPPKVLMSSKSVTYATVVFPGGDKGKIASCEPVQDPPNSQTPPSK
What is the function of this protein?
Cell surface receptor that may play a role in the innate and adaptive immune response.
What are the official names of this protein?
Trem-like transcript 1 protein, TLT-1, Triggering receptor expressed on myeloid cells-like protein 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis.
Protein: CDK12_BOVIN
Sequence: MPNPERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLGSKHKRHKSKHSKDMGLVTPEAAPLGTVIKPLVEYDDISSDSDTFSDDLAFKVDRRENDERRGTDRSDRLHKHRHHQHRRTRDLLKTKQTEKEKNLEASSKSGSTKDRISGSSKRSNEENDDHGKAQISKSSNKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSPKQDDSPSGASYGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPIFLPKKENSSVEAKDSGLEPKKLPRGVKLEKSAPDTELVNVTHLNTEVKNSLDTGKVKLDENSEKHPVLKDTKVQGTKDSKPVALKEEIVTPKETETSEKETLPPLPTVTSPPPLPTTTPPPQTPPLPPLPPLPAIPQQPPLPPPQPTFSQVLSSSTSTLPPSVHPRTSTLSSQANSQPSVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLLGDDDMDSPKETLPSKPVKKEKEQRPRHLLTDLPLPPELPGGDPSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFFFLPWGALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMDPPDLPHWQDCHELWSKKRRRQRQSGVLVEEPPPPKASRKETISGTSAEPVKNSSPAPPQPAPGKVEPGAGDAIGLGDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTAATSQQQDSEPTAPEESLKEIAPAPAVQPSAEQTTPEASSTPADMQNMLAVLLSQLMKTQEPAGNLEENNSDKNSGPQGPRRTPTMPQEEAAGKQTGHESH
What is the function of this protein?
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation.  Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.  Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'.  Required for RNA splicing, possibly by phosphorylating SRSF1/SF2.  Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 12, Cell division protein kinase 12.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.
Protein: TMG4_HUMAN
Sequence: MFTLLVLLSQLPTVTLGFPHCARGPKASKHAGEEVFTSKEEANFFIHRRLLYNRFDLELFTPGNLERECNEELCNYEEAREIFVDEDKTIAFWQEYSAKGPTTKSDGNREKIDVMGLLTGLIAAGVFLVIFGLLGYYLCITKCNRLQHPCSSAVYERGRHTPSIIFRRPEEAALSPLPPSVEDAGLPSYEQAVALTRKHSVSPPPPYPGHTKGFRVFKKSMSLPSH
What is the function of this protein?
May control axon guidance across the CNS (PubMed:28859078).  Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression (PubMed:28859078).
What are the official names of this protein?
Transmembrane gamma-carboxyglutamic acid protein 4, Proline-rich gamma-carboxyglutamic acid protein 4, Proline-rich Gla protein 4.
What is the protein family that this protein belongs to?
Belongs to the commissureless family.
What are the subcellular locations of this protein?
Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
Protein: ARLY_YERPB
Sequence: MALWGGRFSQAADQRFKQFNDSLRFDYRLAEQDIIGSVAWSKALVTVGVLNADEQQQLEQALSVLLEEVQANPHAILASDAEDIHSWVETKLIDKVGDLGKKLHTGRSRNDQVATDLKLWCKFQITELQTAVQQLQQALVMTAEANQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLSRDESRLQDTLKRLDVSPLGCGALAGTAYAIDREQLAGWLGFASATRNSLDSVSDRDHVLELLSDASIGMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMTMTLKGLPLAYNKDMQEDKEGLFDALNTWLDCLHMAALVLDGIQVKRPRCKEAAEQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGKALEALALSDLQQFSSVIGDDVYPILALQSCLDKRVAKGGVSPQQVASAIAEAKARLF
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_METLZ
Sequence: MTIVEDAKKGLITEEMKVVAKSEGVTEDFIRRGIAGGHIVIPMTPYRKVKLCGIGSGLRTKVNASIGTSSDIVNVEEELEKARQAELAGADSLMELSTGGDFLDIRRRVCEQSNLSVGSVPLYQAFIEAARNKGGVVFMDEDDLFKITEQQAKLGTNFMAIHTGINYETVKRLKNQGRHGGLVSRGGAFMTAWMLHNEMENPLYRRFDYLVEILKEHEVTLSFGNGMRAGACHDATDRAAIQELLINAELADQAHNAGVQCILEGPGHIPLDEIKTNVQLEKRVTNNKPFYMLGPLVTDIAPGYDDRVAAIGASVSSAAGADFICYVTPAEHLALPTPEEVYEGVMSSRIAAHVGDMVKLPKTREADLEMGHARRDLDWERQYAVSINAEKARCIRNSRMPADSDACTMCGDFCAIKIVQKTFNF
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: AROQ_HAHCH
Sequence: MASILVLHGPNLNLLGTREPEIYGAETLDDINFRLTETARQAGHHLLTLQSNAEYELIDRIHEAKKEGVDFIIINPAAFTHTSVALRDALLGVGIPFIETHLSNVHAREAFRHHSYFSDVAVGVICGFGSQSYELALQAAFSKITGK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.