PharMolix/UniProtQA huggingface dataset:
Protein: ARM12_HUMAN
Sequence: MGKSIPQYLGQLDIRKSVVSLATGAGAIYLLYKAIKAGIKCKPPLCSNSPICIARLAVERERHGRDSGELRRLLNSLECKQDEYAKSMILHSITRCVYLLEAEASACTTDDIVLLGYMLDDKDNSVKTQALNTLKAFSGIRKFRLKIQEHSIKVLELISTIWDTELHIAGLRLLNNLPLPDYVHPQLRRVMPALMEILQSDYILAQVQAVRLLSYLAQKNDLLYDILNCQVHSNFLNLFQPTQSGSLLYEVLVFAERLSEGRNAPHYHVVKWHYNEQSLHESLFGEESRLADRLLALVIHPEEDVQIQACKVIVSLQYPQDLRARPSSCQPSRSYFKNTE
What is the function of this protein?
Essential for male fertility and sperm mitochondrial sheath formation (By similarity).  Required for proper mitochondrial elongation and coiling along the flagellum during the formation of the mitochondrial sheath (By similarity).  Facilitates the growth and aggressiveness of neuroblastoma cells (PubMed:30026490).  Increases the EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and facilitates the enrichment of polycomb repressive complex 2 and H3K27me3 on gene promoters, resulting in transcriptional repression of tumor suppressors affecting the proliferation, invasion, and metastasis of tumor cells (PubMed:30026490).
What are the official names of this protein?
Armadillo repeat-containing protein 12.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion outer membrane; Peripheral membrane protein.
Protein: YIDD_HELP2
Sequence: MRNNKTPFLSAIFTASIRGYQRFFSAFTPSSCRFYPTCSNYALWLLYFESPLSAMGKIAIRILSCNPFCSGGIAYPVTRLKRPSLLQSHKDFNRNFKTITFWLVPTAKSRTTYYIIKV
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DJC14_MOUSE
Sequence: MAQKHPGERRLCGAHRSGGTSLSTSGSSVDPEILSFSGLRDSAETAPNGTRCLKEHSGPKYTQPPNPAHWSDPSHGPPRGPGPPRGGGYPDESETGSEESGVDQELSRENETGYQEDGSPSFLSIPSACNCQGSPGVPEGTYSEEGDGSSSSLCHHCTSPALGEDEELEEEYDDEEPLKFPSDFSRVSSGKKPLSRRQKHRFLIKEDVRDSGRREPKAPGRHRLARKRSQTDKRRGLGLWGVEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRKLKGSDLDLFRVWVGVWARRLGGWARMMFQFLSQSFFCVVGLLIRILRVVGAFLLLALALFLGCLQLGWRFSVGLGNRLGWRDKTAWLFSWLGSPALHHCLTLLKDSRPWQQLVRLIQWGWQELPWVKQRTKKQGNAPVASGRYCQPEEEVTRLLTMAGVPEDELNPFHVLGVEATASDTELKKAYRQLAVMVHPDKNHHPRAEEAFKILRAAWDIVSNPERRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRVPGTSGRQRATPESPPADLQDFLSRIFQVPPGPMSNGNFFAAPHPGPGTTSTSRPNSSVPKGEAKPKRRKKVRRPFQR
What is the function of this protein?
Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.
What are the official names of this protein?
DnaJ homolog subfamily C member 14.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: S246A_XENLA
Sequence: MQPRRPDRFDGLEYRGTSWGRGEGDPPPYQSSFPARSFSSSGDLSQHWVTTPPDIPGSRNLHWGDKSPQYGGADSNAGPPAFGEENSNSANSGEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHARNYQLSPFNIVNIMYNFTKTQGLRALWKGMGSTFIVQGISLGAEGILSEFTHLPRELNHKWNPKQIGGHLLLKGLVYVIVTPFYSASLIETVQSEIIHDNPGILDCLKEGMGRVLNLGVPYSKRLLPLLVLTFPTVLHGILHYIVSSTVQKCVLFFIKKKSPPRLPADGSNTVQNKLEDYFPELIANFAASLCADVLLYPLETVLHRLHIQGTRTIIDNTDLGHEVVPINTQYEGLKDCINTIKREEGGLGFYKGFGAVVVQYTLHAIVLQITKIIYSSVVQTSS
What is the function of this protein?
May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.
What are the official names of this protein?
Solute carrier family 25 member 46-A.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: GLGB_SYNJA
Sequence: MGFLLSAEQVLQFVTNQWQDPYAVLGPQQIEQGETSFWLVRALVPNAKQVWLVERATGQAYPMQPLHPETLFELCFAPGTPVPDYFLRAQRVWDPEGQHLEEWEDPYRFPLEKVNHIGELDRYLFNEGNHHRIYEKLGAHPISVDGVQGVHFAVWAPNARNVSVIGDFNHWDGRQHQMKRLGESGIWAVFIPGVGPGAVYKYEVKTAWGDIYEKSDPYGFQQEVRPKTGSIVADLHTYTWHDQEWLEKRAATDPLRSPISVYEVHLGSWMHASTEDPPADGHLVPVEQKPNTRFLTYRELADKLIPYVKELGFTHIELLPVAEHPFDGSWGYQVIGYYAVTSRYGSPQDFMYFVDRAHQEGIGVIVDWVPGHFPKDGHGLAFFDGTHLYEYADPRKGEHKGWGTLVFNYGRNEVRNYLIANALFWFDKYHIDGLRVDAVASMLYLDYDRKEWIPNCYGGREHLEAIDFFRQLNTLIFKYYPGVLSIAEESTAWPMVTWPTHVGGLGFNLKWNMGWMHDMLNYFRMDPWFRQFHHNLVTFSLMYAFSENYMLAFSHDEVVHGKSHMLGKMPGDLWHKFASLRALYGYMFTHPGKKTLFMSMEFGQWNEWNVWADLDWELLQYEPHAKLRHYVATLNQLLRSQPALYTQDTKPEGFRWIDCSDHRGIISFIRYGEDPREWLVVVCNFTPVVWPNYRIGVPQRGFYRELLNSDAVEFWGSGVGNLGGKWTDDWPYHNLPYSLELCLPPLSTLVLKWQPPQLAEDSGENKAMLE
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: PRTT_ASPCL
Sequence: MTRTTTLEEVKFEIPTWDNNNHIEVADGSGRSESNASGDTIRPKGRIRRSMTACNTCRKLKTRCDLDPRGHACRRCLSLRIECKLPDTAERFQDNASMWSDATAAIPSIEERLNSLERSMTEMTSMMRQMVDRSPSISGSSVSLLTRSGLTEETASVEGSQPSFIAPRPIRLIQELQSDFLGEPNVLPAESRSLSESFSNGVLDPKLSLKLIQLFVEHFGSWVSIDSPSDIHNDLRPTDPLLYRTACLLASRYVPGIPSSVIQAEYLQIRHAAVNILWNSQPMKYETLQALTLLSLWPTTIQKEAPMDSWLLSGISINHAIISFDFLNHAPAELIVDNDMVAKLRLWNALCLTQLQFAIGNARPFHIQQRYLEHCPRLLEHPAATFDDGKMVAEIQLYLVTSKLQNDPHRMRSAEIEYEEIERWKMEWAHLLTGEQHSTLELNLWYCQLLLYRTAMKCQWESEPLVSEVLRNARLIISKFLLVRFSTALGFVDQTYYIVGYAALNLCDFNPMDPLIDQVQTFLLHLSPNEDHIAYRFSYTISELKRRCTACPNPNSAVKGAFGDARKLNLGQLHFMPQVLDTMMGDYSALEQLMPEVSPHSLPDMLNNVTGELQAGYRTAIL
What is the function of this protein?
Transcription factor required for protein utilization and degradation.  Regulates transcription of major secreted proteases (By similarity).
What are the official names of this protein?
Transcriptional activator of proteases prtT, Zn(2)-C6 zinc finger-containing protein prtT.
What is the protein family that this protein belongs to?
Belongs to the prtT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYT_PEDPA
Sequence: MTEINIEFPDGSVKPFEQGVSILDIAKSISTSLAKKAVAGKINGALVRLDQAINENVKIEIVTKDSEDGNIVNWNSAALVLTSAIESIYPGVHFGEIGNGEHGFYVDTDKVDQQISVDQLPAIEDKMKDIIKSKISLKHSEISVEEALASVDGDPYQAKIVKRNEKNGKVSVYDVDGKIIVSDNVALLSTSDMKAVKLLSVAGAYWEGKSSNPMLQRIYGTSFYKQKDLEAELERQKEAHERDHRVIGNNLDLFFVDPKVGAGLPYWMPNGATIRRSIERYIIDKEVKHGYQHVYTPVLMNLDAYKTSGHWQHYREDMFPPMDMGDGEMLELRPMNCPSHIQVYKHHIRSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVAPDQIQAEFKKVLQLMVEVYRDFNITDYTFRLSYRDPANTEKYFDDDEMWNKSQSMLKAAMDDLGLDYVEAEGEAAFYGPKLDVQTKTALGNEETLSTIQLDFMLPKQFDLHYVGADGEEHRPVMIHRGLVSTMERFTAYLIEMYKGAFPTWLAPKQVTIIPVKDDLHGAYADKLREEMVDKDIRVEVDHRNEKMGYKIREAQTQKIPYILVVGDNELENNSVSVRHYGEDDSKNEASADFINNIVREIESYSREND
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_CAUVC
Sequence: MADKSVKKVVLAYSGGLDTSIILKWLQTEYGAEVITFTADLGQGEEIEPARAKALAAGVKPENIFIEDVREEFVRDYVFPMFRANTVYEGQYLLGTSIARPLIAKKQIEIARKMGADAVSHGATGKGNDQVRFELGYYGLEPDITVIAPWREWDFKSREALLDFAEKHQIQITKDKRGEAPFSVDANLLHSSSEGKVLEDPAVEAPEFVHMRTIAPEDAPDAPTIITIDFEKGDPVAIDGVAMSPATLLTKLNELGRDNGVGRLDLVENRFVGMKSRGVYETPGGTILLAAHRGIESITLDRGAMHLKDELMPKYASLVYNGFWFSPEREMLQAAIDYSQDKVTGRVRVKLYKGNVTVIGRESPYSLYDQDLVTFEEGKVAYDHRDAGGFIKLNALRLRVLAKRDKRG
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBID_STUS1
Sequence: MQYRDLRDFISGLEKRGELKRVTAAVSPVLEMTEICDRTLRKQGPALLFENPTGFDMPVLGNLFGTPGRVALGMGAEDVSELREIGKLLAFLKEPEPPKGLKDAWSKLPIYKKVISMAPKVLKDAPCQEVIVEGDDVDLTKIPVQHCWPGDAAPLITWGLTITKGPNKERQNLGIYRQQVIGRNKVIMRWLSHRGGALDFREWCEKYPDRPYPVAVALGADPATILGAVTPVPDTLSEYAFAGLLRGSRTELVKAIGSELQVPAYAEIVLEGHIHPGEMADEGPYGDHTGYYNEVDRFPVFTVERITHRKNPIYHSTYTGRPPDEPAILGVALNEVFVPILQKQFPEIVDFYLPPEGCSYRMAVVTMKKQYPGHAKRVMLGVWSFLRQFMYTKFVIVTDDDINARDWNDVIWAITTRMDPKRDTVMIDNTPIDYLDFASPISGLGSKMGLDATHKWPGETNREWGRAIVQDPAVKRRVDELWLQLGID
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
Protein: RECF_STRPS
Sequence: MWLQHLSLKTFRNYKETKIDFNPKLNVFLGRNAQGKTNMLEAIYFLALTRSHRTQTDKNLIHFDEEQLHLSGLVQKKTGSIPLEIELTQKGRVTKVNHLKQARLSDYVGHMNVVLFAPEDLQLIKGAPSIRRKFIDMELGQIKPIYLSDLTNYNHILKQRNTYLKSAQKIDETFLSVLDDQLVDYGCRVMNHRLDFIKKLESFGRKKHFELSNQIEELSISYQPSVNITDKQNLSESFKIALEKSRSRDLFKKNTGVGPHRDDISFYINGMDASFGSQGQHRSLVLSIKLAEIELMESITTESPILLLDDVMSELDNTRQLKLLETISQSIQTFITTTSLDHLQNLPENLSIFTIQDGKAAVNGN
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STS1_CANDC
Sequence: MMSTNFHWPTTNKNDNREVSIETPTSTDPHVPRDSLASMPHATASTTIKKRKRDDELDGDKSTTTTTTTTTVSSSSTRKYLQSSLGSSKFKKAKTPKISGQPLPLPRLIESLDRSNLQKLVQGLIAVHPELQSTLIKISPRPSIQDSIQLLQDKFDMIISHLPYKCDVESDYSYLRIKPHLQEFLSSVSDFILNYLPPLETNMTRSLQFLHEATKLVYNLPNFTNQEFQYTKSTALEQIANCWLIVLSQDEEKDGNTDVVKVIHELELLEKLHEHNEISFNKFEKVVDYCKDKLEQHELIMNNNEAGSGVPSSISDLITVDYSKYSIANTTSI
What is the function of this protein?
Involved in ubiquitin-mediated protein degradation.  Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.  Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
What are the official names of this protein?
Tethering factor for nuclear proteasome STS1.
What is the protein family that this protein belongs to?
Belongs to the cut8/STS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: VL1_HPV04
Sequence: MSSWLSTTGKVYLPPAQPVARVLETDEYITGTSLYFHAGTERLLTVGHPYFPVKDVQEPHKVLVPKVSGSQFRVFRFNLPDPNRFALIDNGFYDSDHERLVWKLRGIEIGRGGPLGIGTTGHPLYNKFGDTENPNGYKKQSDDNRQDVSLDPKQTQMFIIGCTPAIGEHWDKAEPCPSPAPQQGDCPPIELVNSYIQDGDMCDIGFGAFNFKALQADKSSAPLDVIATVCKWPDFLKMGKDIYGDSLFFFGRREQLYARHFFVRAGTMGDALPEPFEATSDYFIGAQNQQDQYTLGPHIYVGTPSGSLVSSESQLFNRPYWLNRAQGTNNGICWDNQLFVTLVDNTHNTNFTISVKSDGANDNYQYKASDFKQYLRHIEEFEMEFIFQLCKVPLTADVMAHLNVMNPNILDNWQLNFVPPPPSGIEDQYRFLQSRATRCPTQTPATEKEDPYKDLSFWVVDLSERFSSELSQFSLGRRFLYQSGLINGSLKRKRIISSSHAQTNTKRSAKRKRSLK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: PDXY_VIBVU
Sequence: MQGILSIQSHVAYGHAGNSSAVFPMQRMGFEVWPIHTVQFSNHTQYQEGWTGRAFSADDISELVRGLNNIGALEKCQAVLTGYQGSAEQCLAVEETVTKVKQANPDALYVCDPVMGAPDKGCIVAPGIAENLLNRLMPMADVIVPNQFELSQFAEMEIHTLDDAIIACQRALAKGPKVVLVKHLYCLSDESFNMLLATQEGTYLAKRPHFEFAKAPVGAGDLISAIFTAGLLKGWTPKQAFQHCHDACYGVLNATYQAGEWELQTIAAQQEFVEPSKHFPLEEVTLKTVE
What is the function of this protein?
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxal to PLP.
What are the official names of this protein?
Pyridoxal kinase PdxY, PL kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxY subfamily.
Protein: FAAH_ARATH
Sequence: MGKYQVMKRASEVDLSTVKYKAETMKAPHLTGLSFKLFVNLLEAPLIGSLIVDYLKKDNGMTKIFRNTVIPEEPMFRPEFPSQEPEHDVVIVGEDESPIDRLETALKCLPQYDPSRSLHADPVSSFRYWKIRDYAYAYRSKLTTPLQVAKRIISIIEEFGYDKPPTPFLIRFDANEVIKQAEASTRRFEQGNPISVLDGIFVTIKDDIDCLPHPTNGGTTWLHEDRSVEKDSAVVSKLRSCGAILLGKANMHELGMGTTGNNSNYGTTRNPHDPKRYTGGSSSGSAAIVAAGLCSAALGTDGGGSVRIPSALCGITGLKTTYGRTDMTGSLCEGGTVEIIGPLASSLEDAFLVYAAILGSSSADRYNLKPSPPCFPKLLSHNGSNAIGSLRLGKYTKWFNDVSSSDISDKCEDILKLLSNNHGCKVVEIVVPELEEMRAAHVISIGSPTLSSLTPYCEAGKNSKLSYDTRTSFAIFRSFSASDYIAAQCLRRRLMEYHLNIFKDVDVIVTPTTGMTAPVIPPDALKNGETNIQVTTDLMRFVLAANLLGFPAISVPVGYDKEGLPIGLQIMGRPWAEATVLGLAAAVEELAPVTKKPAIFYDILNTN
What is the function of this protein?
Catalyzes the hydrolysis of bioactive endogenous fatty acid amides to their corresponding acids (PubMed:12824167).  The hydrolysis of endogenous amidated lipids terminates their participation as lipid mediators in various signaling systems (Probable).  Converts a wide range of N-acylethanolamines (NAEs) to their corresponding free fatty acids and ethanolamine (PubMed:12824167, PubMed:16624618, PubMed:16738862, PubMed:16880402).  Can use oleamide as substrate, but not indole-3-acetamide, 1-naphtalene-acetamide, nicotinic acid amide or L-asparagine (PubMed:16738862).  Can use 2-arachidonylglycerol as substrate (PubMed:19801664).  Participates in the regulation of plant growth (PubMed:16880402).  Hydrolyzes N-dodecanoylethanolamine, which is has a growth inhibitory effect on seedling growth (PubMed:28112243).  Involved in plant defense signaling (PubMed:18643971).  Involved in abscisic acid (ABA) signaling through mechanisms that are independent of the catalytic activity (PubMed:19801664).  Involved in the regulation of flowering time (PubMed:22645580).  Catalyzes the hydrolysis of N-acyl L-homoserine lactones (AHLs), which are a class of signaling molecules produced by bacteria for quorum sensing (PubMed:24918118).  Accumulation of L-homoserine appears to encourage plant growth at low concentrations by stimulating transpiration, but higher concentrations inhibit growth by stimulating ethylene production (PubMed:24918118).
What are the official names of this protein?
Fatty acid amide hydrolase, AtFAAH, N-acylethanolamine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the amidase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Cell membrane.
Protein: VM2C1_CRODO
Sequence: MIQVLLVTICLAAFPYQGSSIILESGNVNDYEVIYPRKVTALPKGAVQPKYEDTMQYELKVNGQPVVLHLEKNKGLFSKDYSETHYSPDGRKITTNPSVEDHCYYHGRIENDADSTASISACNGLKGHFKLQGEMYIIEPLELSDSEDHAVFKLENVEKEDEAPKMCGVTQNWESNEPIKKASHLNLNPEHQRYVEIVIVVDHGMFTKYNGDSDKIRQRVHQMVNIMKESYRYMYIDISLAGIEIWSNKDLINVQPAAPNTLKSFGEWRETDLPKRKSHDNAQLLTSIDFNGQTIGIANIGAICDPKPSTRVVQDHSKINLRVALTMTHELSHNLGIHHDTGSCSCSGYSCIMSPVISDEPSKYFSDCSYIQCWNFIMNQKPQCILKKPLRTDTVSTPVSGNELLEARIECDCGSIENPCCYATTCKLRPGSQCAEGMCCDQCRFMKKGTVCRVSLVNKNDDTCTGQSADCPRNVLYG
What is the function of this protein?
Displays low cytotoxicity.  In vitro, inhibits cancer cell migration (human breast cancer cell line MDA-MB-231) with a significant rate after 24 hours of incubation.
What are the official names of this protein?
Zinc metalloproteinase/disintegrin, Metalloproteinase PII, MPII.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted. SUBCELLULAR LOCATION: [Disintegrin Cdc]: Secreted.
Protein: ZED1_ARATH
Sequence: MSKNNKKKRRWDLKNGGILLEELIASFDGKTNPIRCFSSDQILKATDNFSESRIISSWGYFIWYKGVIEERQVSIKKWSSQNLSSFTEAYRDISVSSQMSGHKNALKLIGCCLEFDLPALVCEYTEHGPLNRDGGLSSGVVLPWKVRLKIAKEIASSVTYLHTAFPETIVHRNINPTNIFIDENWTAKLSDFWFCVAIPEGELYVEDDVKGVIGFVDPDYYWTMKVTEKVDIYSFGVVMLVLLSGRAAVFNGPDEAPMSLNDHVSEVMEKGEFDEIVDKEIWNDLGGDDDLVLRRSQVKAFLRLALRCVRYKKEDPVSGMLEVAKELKLIEKLS
What is the function of this protein?
Together with RPP13L4/ZAR1, involved in the ambient temperature (above 22 degrees Celsius)-sensitive aerial organ development (PubMed:28499073).  Together with RPP13L4/ZAR1, involved in the regulation of the ambient temperature-sensitive intersection of growth and immune response in the absence of pathogens, by repressing the transcription of SNC1 (PubMed:28499073).  Probable non-functional kinase required for recognition of the Pseudomonas syringae type III effector HopZ1a by RPP13L4/ZAR1 and, together with SZE1 and SZE2, to trigger subsequent defense responses (PubMed:24170858, PubMed:26355215, PubMed:28652264, PubMed:30947022).  May function as a decoy to trap HopZ1a in the ZAR1 complex for recognition by the plant immune system (PubMed:24170858).
What are the official names of this protein?
Non-functional pseudokinase ZED1, AtZED1, Non-functional pseudokinase ZRK5, Protein CLUSTERED SILIQUE, Protein HOPZ-ETI-DEFICIENT 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. ZRK subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Cell membrane. Note=Associates with the plasma membrane in the presence of the Xanthomonas campestris effector XopAC/AvrAC.
Protein: AMPP1_COPC7
Sequence: MGARGNHTVDTSKQLAALRELMKKENVDVWVVPSEDQHYSEYLAHCDERRAFISGFNGSAGCAVITLDKAYLFTDGRYFLQAEKQLDSNWTLMKQGLPDVPTWQDFLHKTLDGSLKIGIDATIITEEDAAGLRKNLAPKKSELVPSKKNLVDIVWGSERPARPQNPVFHLDEKYSGQSFKEKVKKVREEIAKEKGKAFVVTMLDEVAWLFNLRGSDIDYNPVFFAYAVVTPDEVVLFINEKQLDDAARDYLGQDVKIRGYDELYDYLKELPKSLSLTGDKDGEKILVTSRTSLAITETITPPSSPESTTFHKVVRSPVGDLKAIKNAVEIEGFRQCHIRDGAALARYFAWLEEALNEGKEVSEYAGAEVLEKYRSELDLFRGLSFTTISSTGPNGAIIHYSPDPQDCAIIKKDQVYLCDSGAQFSDGTTDVTRTWHFGTPRPEEVRAFTRVLQGHIAIDTAVFPNGTTGYLIDSWARRSLWQDGLDYRHGTGHGVGHFLNVHEGPQGIGVRIAYNNTALKAGMTVSNEPGYYEDGQYGIRIENIVIVKEVKLPNNFGDKGYLGFEHVTMCPIQTKLIDASLLTEPEKKWVNDYHQEVWQKVSPLLQNDKRALEWLKRETTPI
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase P, AMPP, Aminopeptidase P, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: RF1_ACIC1
Sequence: MFEAVEEVLREYADLERRLADPAVHADPRTARTLGRRYAQLGPIVEAYRRWKALDADVAAAHELAAADPAFRAEIPALEAEREAVAERLRSLLAPADPNDGKDVIMQIKAGEGGEESALFAGDLLRMYLRYAERRGWKTEILDATESDLGGYKDVTVAIRADGSEGAWSRLKFEGGVHRVQRVPVTESQGRIHTSAVGVLVMPEAEEVDVQIDPNDLRIDVFRSSGPGGQSVNTTDSAVRITHLPTGIVVSCQNEKSQLQNKETALRILRSRLLALAQEEAEAQAAAQRRSQVRTVDRSERIRTYNFPENRISDHRVNYKAYNLDQVLDGDLDGVIQALVDADAAARLAAAEQDPTRPVLSRQR
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_DEHM1
Sequence: MIKTKICGLTEVGQALATARTGADFAGVVFAESKRRITTEKALEIAEALKPLNPRPMLVGVFANQTAEEVNRIASVCRLDRVQLSGNESWEYCNQVNLPVIKVIHVAEGTTAELVIQEIQAGLKALKKTPVFLLDTHTKALFGGSGQSFDWQIVKQVSLKYPVMVAGGLNPENIQGFIKIAKPWGIDVASGVETDGIKDTAKIHLFIERVKDADGNRIC
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: CAV3_RAT
Sequence: MMTEEHTDLEARIIKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPEGTYSFDGVWRVSYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSNIKVVLRREG
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  May also regulate voltage-gated potassium channels.  Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.  Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.
What are the official names of this protein?
Caveolin-3.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Cell membrane, sarcolemma. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: GCH4_XANOR
Sequence: MSATLPDVAVTEAFTLSAPLRWVGMQDIAIPVHLDAASGSGLAARASVQVDLPRAELKGIHMSRLYRLLDLHLQRPLSPAMLPQLLQALIESHADCASRAARLTLSFALMLRMPALRSEGLSGWRAYPVRIAAQCRAGRTTIQLQVEVLYASTCPCSAALSRQLLSDAFVQQHAWCDALPLQDVAQWLQDHGSYATPHSQRSVAQVCVDLPADTQGFAIQELIGLCEQALATPVQAAVRRPDEQAFARLNGANLMYVEDAARRLRKQLAEHYATFHVAVRHLESLHAHDAVAETGSDDETFFPAAL
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RPOB_XYLF2
Sequence: MTSYSFTEKKRIRKDFGKHRSILKVPFLLAIQVDSYRAFLQGDVESSQRKDIGLHGALKSVFPIVSYSGNAALEYVGYKLGEPMFDERECRQRGMSYGAPLRVTVRLVIYDRESSTKAVKYIKEQEVYLGEIPLMTENGTFIVNGTERVIVSQLHRSPGVFFDHDRGKTHSSGKLLYSARIIPCRGSWLDFEFDPKDALFTRIDRRRKLPVSILLRALGYSNEEILGEFFEINTFHINPDEGVQLELVPERLRGEILSFNLTDGGSVIVEAGKRITARHVKQLEASGISALAVPDEYLIGRILSHDVIDATTGELLASANSEVNEDRIIAFRKAGIESVGTLWVNDLDRGAYLSNTLRIDPTRTQLEAQVEIYRMMRPGEPPTKEAAQNLFHNLFFTFDRYDLSMVGRMKFNRRVGRKEVAGEPVLYDKKYFSDRNDEESRRLVSKLGETSDILDVIKGLCEIRNGRGVVDDIDHLGNRRVRSVGEMAENVFRVGLVRVERAVKERLSMAESEGLTPQELINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHLSHYGCLCTIETPEGPNIGLINSLAVFARTNQYGFLETPYRKVVEGRVTDEVEYLSAIEENQYVIAQANTLTDDNGQLTESFVPCRFQGESLLKPPSYVHYMDVSPMQTVSVAAALVPFLEHDDANRALMGANMQRQAVPTLRAQKPLVGTGIERTVARDSGVTVNARRGGVIDQVDAGRIVVKVNESEIIGATDAGVDIYGLIKYTRSNQNTCINQRPLVNVGDIVASGDVLADGPSTDIGELALGQNMLIAFMPWNGYNFEDSILLSERVVEEDRYTTIHIEELTCIARDTKLGSEEISADIPNVSEQALNRLDESGVVYIGAEVRAGDILVGKVTPKGESQLTPEEKLLRAIFGEKASDVKDSSLRVPPGMDGTVIDVQVFTRDGIEKDKRAHQIEEYEIKRVKKDFDDQFRILEGAIYARLRSQIVGKVVNSGVDIKKGEVITDPYLDGLKKSDWFALRMKDEVAVEAIDRAQKQIQAYQKEFDQRFSDKRSKITQGDDLAPGVLKMVKVFLAVKRCIQCGDKMAGRHGNKGVISNVVPVEDMPFMEDGTPVDIVLNPLGVPSRMNIGQILEVHLGWAAKGLGHRIQRMLEANAAIADLRKFLNEIYNHDKSLVGERVDLSQFSDDELLNMAKNLTDGVPMASPVFDGASEQEIKRMLDLAELPAGGQTQLYDGHTGEPFDRKTTVGYMHYLKLNHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVQGRNQMYKNIVDGDHQMVAGMPESFNVLVKEIRSLAINIELEDN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.