PharMolix/UniProtQA huggingface dataset:
Protein: RRF_DEHMC
Sequence: MINEILQKSEKKMSASLDVLLQELSGIRTGRSSPALVEHIRVEYAGVPTPINHLANISAPDPRYITIQPWDRSCLSAIEKAIMKSDLGLMPNNDGNIIRLNIPPLSEERRQEMIKIVNKRLEEDKIAMRNVRRDAMDEMKKLEKAKEISQDDLKRGSDQLQKITDNFIAKADKLGADKEAELRQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_RHOCA
Sequence: MSGIPHDHYEPKTGIEKWLHDRLPIVGLVYDTIMIPTPKNLNWWWIWGIVLAFTLVLQIVTGIVLAIDYTPHVDLAFASVEHIMRDVNGGWAMRYIHANGASLFFLAVYIHIFRGLYYGSYKAPREITWIVGMVIYLLMMGTAFMGYVLPWGQMSFWGATVITGLFGAIPGIGPSIQAWLLGGPAVDNATLNRFFSLHYLLPFVIAALVAIHIWAFHTTGNNNPTGVEVRRTSKADAEKDTLPFWPYFVIKDLFALALVLLGFFAVVAYMPNYLGHPDNYIQANPLSTPAHIVPEWYFLPFYAILRAFAADVWVVILVDGLTFGIVDAKFFGVIAMFGAIAVMALAPWLDTSKVRSGAYRPKFRMWFWFLVLDFVVLTWVGAMPTEYPYDWISLIASTYWFAYFLVILPLLGATEKPEPIPASIEEDFNSHYGNPAE
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
What are the official names of this protein?
Cytochrome b.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARGB_CELJU
Sequence: MSLSRESAMNIANVLTEALPYIQRFTGKTVVVKFGGNAMEGEALQNSFARDIVLMKLVGMNPVVVHGGGPQIGSLLEKLNIKSEFINGMRVTDSATMDVVEMVLGGTVNKQIVSLINRNGGQAIGLTGKDGQLIRAKKLTVTHKTPEMLAPEILDIGHVGEVQSVNTAVIDMLINSDFIPVIAPIGVGEDGASYNINADLVAGKIAEFLRAEKLMLLTNVSGLQDKQGNVLTGLSTEQVDALIADGTIYGGMLPKIACALDAVKGGVTSAHIIDGRVDHAVLLEIFTDAGVGTLITNKPKA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_DESVH
Sequence: MTKEFNYGTGRRKTATARTRLYPGTGVIEINGRPYEEFFPRKTLQMIIRQPLVLTKMLEKFDVKVNVAGGGISGQAEAVRHGISRALLELDAELRPVLKRAGFLTRDARKKERKKYGLRAARARYQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: NU4M_RHIUN
Sequence: MLKIIIPTLMLMPLTWLSKNNMIWINTTAYSLLISLISLSFLNQFNEDSLYISLTFFSDPLSAPLLVLTTWLLPLMIMASQHHLSKEPITRKKLYITMLIMLQLLLIMTFTATELILFYVLFEATLIPTLIIITRWGNQTERLNAGFYFLFYTLTGSLPLLIALIHIQNITGSLNLLLIQYSAQTLPNSWSNTFLWLACMMGFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAILLKLGGYGMLRITMILNPLTSHMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSYMGATALMIAHGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVSSFSWSNLTIILMGTNIIITALYSLYMLIMTQRGKYTYHINNIKPSFTRENMLMALHLLPLLLLSLNPKIILGTMY
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPOB_PSEPK
Sequence: MAYSYTEKKRIRKDFSKLPDVMDVPYLLAIQLDSYREFLQAGASKDHFRDVGLHAAFKSVFPIISYSGNAALEYVGYRLGEPAFDVKECVLRGVTFAVPLRVKVRLIIFDKESSNKAIKDIKEQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDRGKTHSSGKLLYSARIIPYRGSWLDFEFDPKDCVFVRIDRRRKLPASVLLRALGYSTEEVLNTFYTTNVFHISGEKLSLELVPQRLRGEVAVMDIHDETGKVIVEQGRRITARHINQLEKAGVKQLDVPMEYVLGRTTAKAIVHPATGEILAECNTEMTTELLIKVAKAQVVRIETLYTNDIDCGPFISDTLKIDTTSNQLEALVEIYRMMRPGEPPTKDAAETLFNNLFFSAERYDLSAVGRMKFNRRIGRTEIEGSGVLSKEDIVEVLKTLVDIRNGKGIVDDIDHLGNRRVRCVGEMAENQFRVGLVRVERAVKERLSMAESEGLMPQDLINAKPVAAAVKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLAAYARTNQYGFLESPYRVVKEGVVSDDIVFLSAIEEADHVIAQASAAMNDKKQLIDELVAVRHLNEFTVKAPEDVTLMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMERNVARDSGVCVVARRGGVIDSVDASRIVVRVADDEVETGEAGVDIYNLTKYTRSNQNTCINQRPLVSKGDKVQRGDIMADGPSTDMGELALGQNMRIAFMAWNGFNFEDSICLSERVVQEDRFTTIHIQELTCVARDTKLGPEEITADIPNVGEAALNKLDEAGIVYVGAEVGAGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPTGTKGTVIDVQVFTRDGVERDSRALAIEKMQLDEIRKDLNEEFRIVEGATFERLRSALNGQVVDGGAGLKKGTVITDEVLDGLEHGQWFKLRMAEDALNEQLEKAQQYIVDRRRLLDDKFEDKKRKLQQGDDLAPGVLKIVKVYLAIRRRIQPGDKMAGRHGNKGVVSVIMPVEDMPHDANGTPVDVVLNPLGVPSRMNVGQILETHLGLAAKGLGEKIDRMLEEQRKAAELRVFLTEVYNEIGGRQENLDEFTDEEILALANNLKKGVPMATPVFDGAKEREIKAMLKLADLPESGQMVLFDGRTGNKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEPGMPESFNVLIKEIRSLGIDIDLETE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RBSA_CORGL
Sequence: MVNSEQALHQHDPAPILQLDKVSKSFGPVNVINQVSIDVRPGRVLALLGENGAGKSTLIKMMSGVYQPDGGQILVDGKPTTLPDTKTAESFGIATIHQELNLVPTMTVAENVMLGRTPRKWGLVNFKHLRRQAQAALDLIGVDVDLNAQVGSLGIARQQMVEIAKALSMNARILILDEPTAALTGREIDQLFKVVDQLKEKGVAMVFISHHLDEIARIGDTVSVLRDGQFIAELPADTDEDELVRLMVGRSIENQYPRSAPEIGQPLLEVKNLNAEGRFTDISLTVRAGEVVGLAGLVGAGRTEVVRSIAGVDKVDSGEVIVAGKKLRGGDISEAIKNGIGHIPEDRKAQGLVLGSSVEDNLGLATLASTARAGLVDRSGQHKRAAEVAEKLRIRMASLKQPISDLSGGNQQKAVFGRWVLAGSNVLLLDEPTRGVDVGAKVEIYNIINEMTEKGGAVLMVSSELPEVLGMADRILVMSGGRIAGELPAKGTTQDDVMALAVSQVDDSITEEAAAEIENTKEDR
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UPPP_STRP2
Sequence: MYLIEILKSIFFGIVEGITEWLPISSTGHLILAEEFIQYQNQNEAFMSMFNVVIQLGAILAVMVIYFNKLNPFKPTKDKQEVRKTWRLWLKVLIATLPLLGVFKFDDWFDTHFHNMVSVALMLIIYGVAFIYLEKRNKARAIEPSVTELDKLPYTTAFYIGLFQVLALLPGTSRSGATIVGGLLNGTSRSVVTEFTFYLGIPVMFGASALKIFKFVKAGELLSFGQLFLLLVAMGVAFAVSMVAIRFLTSYVKKHDFTLFGKYRIVLGSVLLLYSFVRLFV
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROB_AERS4
Sequence: MERLKVELGERSYPIEIAAGLLQHAEVLTQTIKGKRVMIVTNTVVAPLYLERIIQLLSGFQVEHLILPDGEAYKTLATFERIMSALLETNHGRDTTLIALGGGVIGDVVGFAAASYQRGIPFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPKHVVIDTECLKTLPAREFAAGMAEVIKYGIIWDAEFFSWLETNMSRLQALEPAALAYAIRRCCEIKADVVTQDETEHGVRALLNLGHTFGHAIEAEKGYGNWLHGEAVAAGMMMAASTAEARGDLDARQLARIRDLLLAANLPIQAPADMDFSAFIRHMRRDKKVLEGKLRLVLPVGIGHAQVVADVSDDELLAVIESGRE
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_CLOP1
Sequence: MNGVINIYKNTGMTSFDVVAIVRRVAKMKKVGHTGTLDPAASGVLPVCLGKATKIIDYIMENKKVYRVNLKLGMVTDTYDLEGEVLREEDASHITKDEILNCINSFLGTIDQVPPMYSALKQNGVRLYELARQGIEVHREARKITIYSIENIKIESNDNIQMDVCCSKGTYIRSLCYDIGEKLNVGATMTALERIQNGTFTKEEAINIEDLTEELLEKHIISIEKALDSFEKITVNEKFGKLLRNGVKVFDNRMYSEEVEFNKLYRVYEDNGVFLGLGKRDEKGFKLEKLLIEE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: PKS4_CALOD
Sequence: MPPNTVNKAAEIPPFEPIAIVGIGIRGPGGINSLTTLWDTLVERKSHCFPLAKDPRFQRRFNPDDFKALFDGIPDSENVLHANLFDETPGLDRTYFSLSEREAAGMDVQQKLLLHVAHEALEDAGYSGAEDGSAFDPSTFGVYVATATDEVIQDPRDYDTDIYHLVRTERAFLSGQICFHFGLRGPSSSVDTVCSGSITAINDACRALATGDCRAAIAGGVHVVTPVSGPISFYCIKRAGFLDRTGQCKPFLQNGTGYSRSEGCGLVVMKRLSDAIREGDRIHGVIRGLCIRSMASPKFISQPNGAFQSVALAQAVKISGVDPAAISFVEAHGPGTAKGDLAEVSSLCSVLAQHRAVDNPLTVGSLKGNVGHAEAASGTHSLAKVIAMFQRRRIPPQADFHPSRLNPTLQPFFDKHPIRIIENEEDWNASHRIAVVGNFGASGNAGFMVIEEGSTFQPLEGRDVPKVSSPLPFVISAKDQATLVKLIHLYIDWLKQPSTFLTPLSDISYAMTARRFIHPFMISVQADSHMDLVQKLQERPPMINGSANRTPREVAFCFSGQGGERVDPRDSTLYNFSASFTDAVDMCFRVAESENLVAEEDVAILELFALEFGLVEMWKSWGIKPVALAGHSFGEYVALVCAGVLTVRDALKLLGIRAALIRAMCLDVPGKMAAVRLPLSDVNKCLEQQKSTRVELACVNSDNSVTVAGTPEDLESFRQELLKWYPAASWHLLNNMTAAFHSRFVQPILADFTNACNEVKVHPSEMVVLSGLLGKMCPVGDAVLQQHDYLVRHCRETNRFGTAISDYQRQNVERETPQPDWLEIGSHSRIISFITPASDQLKLPSHGKSAGEGWMTALDALMRLYSAGHVVDFKDVHYDVNPSAHHTDLPLYPFQLEPHFYPARREVKASSTMLASTNEVQFCPRVPSTELAPLLLNHVMAGYTLCPATTHVALMMAAASTFASSSQQEGRLAYKLSKLKVIAGFTNTTDGWLQVRRQSSTSDLEIISNDDNKIHITARAEVCKEQDLLESLSLYASFILPFKSFKFLPSTDVLRKELAYSLFNHTVNYGPHGQVLDRVWIAEDGYQAWGYSTYPGGASTAEGVPSALRDFSPMLIESVCQLIGFLMNTSTNRKDGEAFVTDELGDCSIAISKLYETKYVEIYASYKMVDGGTAGLGNVFAFDDKGQLISAFRDVRMAKMKIYVLKRLIDRGRKPEQVVTTQHVASTEVEEDNVAHNDIDDKVISVLKAALRLSEIPLDKTLGELGLDSLTAIDVGVQLERLVPHRRDHLTIDPEGNLTSLLQLLRPTPLPKSLPITSSTKESKVETVDLATSPSLPIMPNGVPTTVNGVPKPNALPTVNGLHKPNGAPAANGVPTANGVPTADGTSTEPSQTLVANISPEMLQAISSNPEVIQYAPGRTPLLLIHDGGGTSFAYYSLGNLDRTVIGIHCPGLQEGKGIESVHHAANEYANIARQYLKQQCPGHSKVLIGGWSLGGTISMMMAALFPDLVAGVVTIDTTPPGVVGLTAQQAESVLLHPWSRTDGIHGLVRRQLQLNTRASFAHPEYKTIIRVTAVNVPVYVLCAIDPFRPSESLDLPKETYQWLLSFKQSDVAEVTWKELIGERLLGVQSVPGNHWTMFTPANVKATTEALKQGLDVIEARLNKMG
What is the function of this protein?
Non-reducing polyketide synthase that synthesizes the universal anthraquinone precursor atrochrysone carboxylic acid from malonyl-CoA (PubMed:35218274).  Produces a mixture of both 3R and 3S enantiomers with an excess of the 3S form (PubMed:35218274).  PKS4 catalyzes both hepta- and octaketide synthesis and yields also 6-hydroxymusizin, probably via carboxylating activity inherent to the KS domain (PubMed:35218274).
What are the official names of this protein?
Atrochrysone carboxylic acid synthase PKS4, ACAS, Non-reducing polyketide synthase 4.
Protein: B9D1_DROME
Sequence: MSASEGISLPGNEETTPPHEKHKQKAKKAKKKSRSAKESVPNAMDAKATASYFSLSIVGQIVSATFPLGPDKEFVFLRYEMVAGPDWQLSSGPQHGLTQLATNRRGHFNEPIVFNMPIEVTYKSTSPYGWPQILVTVFGRSGLGRETLLGYAHIHLPVFGSRRPADQTEQLQAPILMPKCPNMMADITSWLLRREPELKDPKVLLDNLKCKGLSMESYGSLQFQLSSVMRGARKLGYHWHS
What is the function of this protein?
Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27577095, PubMed:27646273).  Required for ciliary structure and function (PubMed:27577095).
What are the official names of this protein?
B9 domain-containing protein 1, MKS1-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the B9D family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone (TZ), a region between the basal body and the ciliary axoneme in the olfactory, auditory and speromatocyte system (PubMed:27646273, PubMed:30013109). In spermatocytes, localizes in the transition zone and the migrating base of the spermatid ciliary cap (PubMed:25447994, PubMed:27577095). Co-localizes with the tectonic-like complex (PubMed:27646273).
Protein: TRPA2_CYACA
Sequence: MFIAYLTAGAPDLNTTKQALLNLANDGADVIEIGVPYSDPLADGMILQKASQQALKNRFRLEQLWHLLAEIELPVPVVILAYYNQIFHYGVEKWVTTLVNLKVKALIVPDLPYEEAAILRAACARHHLHMIWLISPTTPKVRAKQLALACDDWIYLVSRTGVTGVDAHFDNQIPNMIAELKQVTTTPIALGFGIHQKQQLQLVKSWGADGVIIGTACMQILLEKGVDQLTEWISAMKKSSYP
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RPOA_NEIMB
Sequence: MQNSTTEFLKPRQIDVNTFSATRAKVSMQPFERGFGHTLGNALRRILLSSMNGFAPTEVAIAGVLHEYSTVDGIQEDVVDILLNIKGIVFKLHGRSQVQLVLKKSGSGVVSAGDIELPHDVEILNPGHVICHLADNGQIEMEIKVEQGRGYQSVSGRQVVRDENRQIGAIQLDASFSPISRVSFEVEPARVEQRTDLDKLVLDIETDGSIDPEEAVRSAARILIDQMSIFADLQGTPVEEVEEKAPPIDPVLLRPVDDLELTVRSANCLKAEDIYYIGDLIQRTETELLKTPNLGRKSLNEIKEVLASKGLTLGSKLEAWPPVGLEKP
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: TSR3_SULIL
Sequence: MKVYVIDYHKDDPKKCTGRKLVKLKLAELTRVGRGIILNPFSERTLSINDKDILIKSGITIIDTSWNNTSQNEFKNVRGEHRRLPILFAGNPIHYGIAYKLSSLEALMATLYILDEVKEAIKFSNVVKWGHTFIELNKELLEAYRNKDEEEIKKIEKEIIEKILRK
What is the function of this protein?
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M. jannaschii 16S rRNA.  It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
What are the official names of this protein?
16S rRNA aminocarboxypropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TDD superfamily. TSR3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REOX_BIFAA
Sequence: MTNATDTNKTLGESMFAQCGYAQDAIDKRVSQVWHEIFEGPNKFYWENDEGLAYVMDTGNNDVRTEGMSYAMMIALQYDRKDVFDKLWGWVMRHMYMKDGHHAHYFAWSVAPDGTPNSNGPAPDGEEYFAMDLFLASRRWGDGEDIYEYSAWGREILRYCVHKGERYDGEPMWNPDNKLIKFIPETEWSDPSYHLPHFYEVFAEEADEEDRPFWHEAAAASRRYLQAACDERTGMNAEYADYDGKPHVDESNHWHFYSDAYRTAANIGLDAAWNGPQEVLCDRVAALQRFFLTHDRTSVYAIDGTAVDEVVLHPVGFLAATAQGALAAVHSAQPDAEHNAREWVRMLWNTPMRTGTRRYYDNFLYAFAMLALSGKYRYE
What is the function of this protein?
Hydrolyzes xylooligosaccharides with a degree of polymerization of greater than or equal to 3, releasing xylose from the reducing end.  Has low activity on birchwood xylan, oat spelt xylan and arabinoxylan.
What are the official names of this protein?
Reducing end xylose-releasing exo-oligoxylanase, RexA.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 8 (cellulase D) family.
Protein: NEIL3_XENLA
Sequence: MEALPPQVLKPLDCMSIYSRHREPENRHNELSTGRCGRGHVIFSSMKALQPQVLKPTGSHANLQQVLYAPAATIITAPASSHNDLSSLTGCSYAGVETLGKELFIYFGLKAMRVHFGMNGSMRINQPMKKGQENGRPIPIAVLEVQLTKDLICFYESTVDVRNASECQEKIRFFEELDVCSSKFSFPRAECEIKKQRTRMLCDILLDQMILPGVGNIIKNEALFDSGLHPGVQAGLLTDEQVSHLVKMTRDFTLLFYKCRKSGSALYKHYKVYKRPNCGQCGTKITVCRLGEHNRMTYFCPKCQKDKPQHVDVSKLPTRNSLIGWVQRTASNANEHVATSKEEHWACAVCTLINKPSDKQCDACLTLRPEVSSLAVSDEAAELNTDLVKYPCNNFAKVLPELKLNRRTAFGNTTLVLTDFGAKEGLADKNSQQNILNRSTFDVPLNNKYYHTKTPSNKRSNENEHWTNTLNAVNGHSAASNNVFNHPQKKLKTGHTTSNTIHLSSTISSPQSKMTGDAAAKTGNPQCSAHNVPCALQVVRKEGENKGRSFYTCSLPRERRCQYFEWADLHFPFCNHGKRCIVRTVLKIGPNNGKNFYVCPMGKDKQCNFFEWAKTE
What is the function of this protein?
DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:30842657).  Mediates interstrand cross-link repair in response to replication stress: recruited to replication stress sites via interaction with ubiquitinated CMG helicase and acts by mediating DNA glycosylase activity (PubMed:30842657).  Cleaves one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (PubMed:30842657).
What are the official names of this protein?
Endonuclease 8-like 3, DNA glycosylase/AP lyase Neil3, Endonuclease VIII-like 3, Nei-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Recruited to replication stress sites via interaction with ubiquitinated CMG helicase.
Protein: QUEA_CLOK5
Sequence: MEVTDFDFYLPEELIAQKPLEQRDEGRLMVLDKKTGKVCHKIFKDIVYYLNPGDCVVLNDTRVLPARLIGVREDTMGKIEFLLLKRRDNFTWETLVKPGRRAKVGNRFNFGSGQLKAEVVSINEDGNRIVRFEYNGVFEEILDKLGQIPLPPYIKEKLENKELYQTVYSKEEGSAAAPTAGLHFTEELLRELREKGVNLAFLTLHVGLGTFRPVKVENIEDHAMHSEFYSMSKETADMINAAKESGHSVISVGTTSCRTLETIGDENGRVKEQSGWTDIFIYPGYKYKVVDKLITNFHLPKSTLIMLVSAFYGRENTLHAYNVAVKEKYRFFSFGDAMFIK
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNMT_HUMAN
Sequence: MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
What is the function of this protein?
Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117).  Other substrates include phenylethanolamine and octopamine (PubMed:8812853, PubMed:16363801, PubMed:16277617).  Also methylates normetanephrine (By similarity).
What are the official names of this protein?
Phenylethanolamine N-methyltransferase, PNMTase, Noradrenaline N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
Protein: KHSE_BACHK
Sequence: MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIVSTACKVCPSLSPHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTIDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVISLIPNEELNTDESRSVLPDVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMERDHFHEPYRLELVPLLPSIRKCAKEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTB7_MYCLE
Sequence: MAEDVRAEIVASVLEVVVSEGDQIGKGDVLVLLESMKMEIPVLAGVAGIVSKVSVSVGDVIQAGDLIAVIS
What are the official names of this protein?
Biotinylated protein TB7.3 homolog.
Protein: DML3_ARATH
Sequence: MLTDGSQHTYQNGETKNSKEHERKCDESAHLQDNSQTTHKKKEKKNSKEKHGIKHSESEHLQDDISQRVTGKGRRRNSKGTPKKLRFNRPRILEDGKKPRNPATTRLRTISNKRRKKDIDSEDEVIPELATPTKESFPKRRKNEKIKRSVARTLNFKQEIVLSCLEFDKICGPIFPRGKKRTTTRRRYDFLCFLLPMPVWKKQSRRSKRRKNMVRWARIASSSKLLEETLPLIVSHPTINGQADASLHIDDTLVRHVVSKQTKKSANNVIEHLNRQITYQKDHGLSSLADVPLHIEDTLIKSASSVLSERPIKKTKDIAKLIKDMGRLKINKKVTTMIKADKKLVTAKVNLDPETIKEWDVLMVNDSPSRSYDDKETEAKWKKEREIFQTRIDLFINRMHRLQGNRKFKQWKGSVVDSVVGVFLTQNTTDYLSSNAFMSVAAKFPVDAREGLSYYIEEPQDAKSSECIILSDESISKVEDHENTAKRKNEKTGIIEDEIVDWNNLRRMYTKEGSRPEMHMDSVNWSDVRLSGQNVLETTIKKRGQFRILSERILKFLNDEVNQNGNIDLEWLRNAPSHLVKRYLLEIEGIGLKSAECVRLLGLKHHAFPVDTNVGRIAVRLGLVPLEPLPNGVQMHQLFEYPSMDSIQKYLWPRLCKLPQETLYELHYQMITFGKVFCTKTIPNCNACPMKSECKYFASAYVSSKVLLESPEEKMHEPNTFMNAHSQDVAVDMTSNINLVEECVSSGCSDQAICYKPLVEFPSSPRAEIPESTDIEDVPFMNLYQSYASVPKIDFDLDALKKSVEDALVISGRMSSSDEEISKALVIPTPENACIPIKPPRKMKYYNRLRTEHVVYVLPDNHELLHDFERRKLDDPSPYLLAIWQPGETSSSFVPPKKKCSSDGSKLCKIKNCSYCWTIREQNSNIFRGTILIPCRTAMRGAFPLNGTYFQTNEVFADHETSLNPIVFRRELCKGLEKRALYCGSTVTSIFKLLDTRRIELCFWTGFLCLRAFDRKQRDPKELVRRLHTPPDERGPKFMSDDDI
What is the function of this protein?
Potential transcriptional activator that may act by nicking the target promoter.  Catalyzes the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism (By similarity).
What are the official names of this protein?
DEMETER-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase family. DEMETER subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL22_STUS1
Sequence: MEVAAKLSGARISAQKARLVADQIRGKKVGDALNLLAFSSKKAAEIMKKVLESAVANAEHNEGADVDDLKVSTVFVNEGRSLKRIMPRAKGRADRIVKRSCHITVKVADK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: Y1879_PHOV8
Sequence: MAEHNEFGKEGEEEAAAYLIDKGYSIRHRNWHCGKKELDIVAEYRNELIVIEVKTRKNTRFGNPEDAVTDKKIRRIIASTDAYLRKFSVDLPVRFDIITLVGEKTPFTIEHIEEAFYPPIW
What are the official names of this protein?
UPF0102 protein BVU_1879.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: PAPS2_MOUSE
Sequence: MSANFKMNHKRDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVARLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPECVLKTNLSSVSDCVQQVVELLQEQNIVPHTTIKGIHELFVPENKVDQIRAEAETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEYLQTLHFDTLLDGVVPRDGVINMSIPIVLPVSADDKARLEGCSKFALMYEGRRVALLQDPEFYEHRKEERCSRVWGTATAKHPHIKMVMESGDWLVGGDLQVLERIRWDDGLDQYRLTPLELKQKCKDMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLEWRMKQHAAVLEERVLDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHEEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKTN
What is the function of this protein?
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway.  The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases (PubMed:10559207).  In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway.  May have an important role in skeletogenesis during postnatal growth.
What are the official names of this protein?
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2, PAPS synthase 2, PAPSS 2, Sulfurylase kinase 2, SK 2, SK2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the sulfate adenylyltransferase family.