PharMolix/UniProtQA huggingface dataset:
Protein: SPSB4_MOUSE
Sequence: MGQKLSGSLKSVEVREPALRPAKRELRGLEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQIHWPARQRGTHAVVGVATARAPLHSVGYTALVGSDSESWGWDLGRSRLYHDGKNRPGVAYPAFLGPDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLRDIGSLPLPQSLKNYLQYQ
What is the function of this protein?
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity).  Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity).  Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of the EphB2/CTF2 (By similarity).  Regulates cellular clock function by mediating ubiquitination and proteasomal degradation of the circadian transcriptional repressor NR1D1 (By similarity).
What are the official names of this protein?
SPRY domain-containing SOCS box protein 4, SSB-4.
What is the protein family that this protein belongs to?
Belongs to the SPSB family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Note=Exhibits a diffuse cytosolic localization.
Protein: ISPD_NEIG2
Sequence: MKRKNIALIPAAGIGVRFGADKPKQYVEIGSKTVLEHVLGIFERHEAVDLTVVVVSPEDTFADKVQTAFPQVRVWKNGGQTRAETVRNGVAKLLETGLAAETDNILVHDAARCCLPSEALTRLIEQAGNAAEGGILAVPVADTLKRAESGQISATVDRSGLWQAQTPQLFQAGLLHRALAAENLDGITDEASAVEKLGVRPLLIQGDARNLKLTQPQDAYIVRLLLNAV
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: G2L2L_XENLA
Sequence: MCIALSHSLAALNSGIMSTHQGGSVRSIRPFKSSEEYLYAMKEDLAEWLKDMYHLEIIVDNFTEILENGSVLCQHANNVTEVAREFSVQYPQLAEKLQLPKSGVKLNMMAQPGTFLARDNVSNFIQWCRKEMDIKDVLMFETEDLVLRKNEKNFVLCLLELARRASRFGMSAPMLIQMEEQIEEEIREEMDLPPPEIPVPKPQRKLCDFKNLDQMVQHLVSRCTCPVQFSMIKVSEGKYKVGESSTLIFVRILRKHVMVRVGGGWDTLEHYLDKHDPCRCTSLSHKPAIKLGSLQKQVSAVHEVKTRLTPRLDNPSKVETTLIVSRSQSPLPPVEWRSYSSGRTRTTSSSNSLDNNENSPTFKMSPSDRRSMSTSYRAHERSATPSRKLFTEDNPEPQQLGNPQSVNFRHHHSTSSLASQLTGSEEENSCLSEVFSESQSRRQMGRTTVMSLKEPAMKEAFLSHTQSAHRKVMSATEQNNIQQGSRIVNQSINSQDSRPKTPSRFIRPPSPSKQIHFFHNQQNKGVEQNPKTQINSCTRSPSPVKQTSLTYKQEFTKRPATPSRISSQYKDGDKSAATEIIPSQDHIKSKPSVSSEERTIRTGRSTPTIHLNKNGITYREVSNLPPRMQPKPDALELSHSIERDCMYTPLPIDPEQEKQIYRSLEDEILTNIKVLEGDSEENHPENDSHGFNMLEKSTLPLNASTLKNPSGQGSVPRSGVYINTTWQSGACYDDVITELTKGHVKLNRVDVENWISKIPSKGMVKEAEEAHTSQRNQVRENGHTGAVSQRTIVRKKTPSTEIKGSKPKQLPSQRARQLALENKKKTVDNVSENQASTFSGDSGETVQEKIKLSQGLKPKRTLKKPERVPSIYKLKLRPKIRPRRDNRPEKKPSRIPTPVSYRQMPSRNNGKAVKRTQSYQANKTSAPQTLNESQSSTVILEDLDSDDKTLEHSAPSQAVETPVTIGNDQSKTEEEEESWV
What is the function of this protein?
Together with gas2l2. S, regulates ciliary orientation and performance.
What are the official names of this protein?
GAS2-like protein 2A, growth arrest specific 2 like 2 A.
What is the protein family that this protein belongs to?
Belongs to the GAS2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body.
Protein: RS12_SHISS
Sequence: MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RS15_HELPJ
Sequence: MALNLEKKQEIIKAFATKANDTGSCEVQVALLNERIKLLTEHLKTNPKDHSSRLGLLKLVAQRRNLLKYIKRTDHVRYVVLIEKLGIKDR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: TRMD_GEOSM
Sequence: MKFDILTLFPAMFEGPLTESILKRASEKGLIEVALHNIRDWAFDKHATADDAPYGGGAGMVMKVEPIAGAIEAVKAKRPNSKVVLTTPCGRPFNHQVAEELSREEGVVIICGRYEGVDERVRTLCVDDEISLGDFVLTGGEIAAMVIVDAVSRLVPGVLGSDESAQYDSFADGLLEYPQYTRPPEFRGEKVPDILLSGNHAEIAKWRRKEQMKRTLASRPELLDGIEWSKADKKLFAEVEKADQEKVAR
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y779_METJA
Sequence: MPKYLTTLYKRTIKRNIILFKKLGKDFDEKKFILLLIIIAAIPLLISYYLHLTLKSMIIFVVIYVGAALFIPSILYENKIETLENNIPQALYIMILALESGRSINEALLEVVKSNIKEVSDIFRKVLYLMENQKLSFEESMTIVSNLYDSKVLRMLARIMIENRKYGGDLSDSLKILAKTLEDFKMYKRQLLSVTASGLAIGFIILCGVIPAVAALLGAYLIAVSGMLSGVAPIPPVKPEDISKGFEIVQMGTAIIGALFAIPIFGLKIGRMFLISAVTMTIGVLAYYTILKFAPGIFS
What are the official names of this protein?
Uncharacterized protein MJ0779.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RDGC_AERHH
Sequence: MWFKNLQIYRFTRPFELTVEQLETQLEACAFTPCGSQDISRFGWVKPLGKFGSTLTHSAAGHILICARKEEKMLPGTVVKEMLAEKVEAIEFEQGRALKKKEKEALKEEILHTLLPRAFSRTSQTFAWINPADNLMVVDAGSAKKADDLLALLRKSIGTLPVVPVALKNPPEITMTEWLNEGNLPASFTLEDEAELRSAMEHGGIIRCKQQDLMTDEIKNHLANDKLVTKLALNWGETLSFVLGDDLSIKRLKFSEELREQNDDVTSEDPAARLDADFALVTAELAQFIPALFAALGGEEQSI
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: BAM4_ARATH
Sequence: MTETGVIGCGCRGVTGGNFFHPGGFSLKSCFLEQSTKRNRNFFRSVSMIPPFKRGRFITKLRSVAGNSRIFSMDAREKSRSFVLVSSRHKRVPVFVMMPIDTFGIDASGCPKIKRLKALTVSLKALKLAGVHGIAVEVWWGIVERFSPLEFKWSLYEELFRLISEAGLKLHVALCFHSNMHLFGGKGGISLPLWIREIGDVNKDIYYRDKSGFSNNDYLTLGVDQLPLFGGRTAVQCYEDFMLSFSTKFEPYLGNVIEEISIGLGPSGELRYPAHPSGDGRWKFPGIGEFQCHDKYMMEDLMAVASQEGKPQWGSRDPPNTGCYNSFPSGVPFFEEGNDSFLSDYGRFFLEWYSGKLICHADAILAKAADVLRRRQEEEKSSVMLVAKIGGIYWWYKTSSHPAELTAGYYNTSLRDGYDPVASVLSRHGAALNIPCLDMADSEIPEKYLCSPEGLRRQIHDVSKKWTIHVTGRNTSERFDEMGLRQIRENCVQPNGDTLRSFTFCRMNEKIFRVENWNNFVPFIRQMSADM
What is the function of this protein?
No alpha-1,4-glucan hydrolase activity, including beta-amylase, alpha-amylase, a-glucosidase or alpha-amyloglucosidase.  However, facilitates or regulates starch breakdown, especially at night, by a mechanism involving direct interaction with starch or other alpha-1,4-glucan.
What are the official names of this protein?
Inactive beta-amylase 4, chloroplastic, Inactive beta-amylase 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS10_HELPJ
Sequence: MEKIRLKLKAYDHRVLDRSVVAIVEAVKRSGSEIRGPIPLPTKNKRYTVLRSPHVNKDSREQFEIRVYSRLIDIISATPETVDSLMKLDLAPEVDVEVTSMETK
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: KUP_STRE4
Sequence: MSNAHHDAFDKATKAGFIIALGIVYGDIGTSPLYTMQSLVDNQGGLSQVSEAFILGSVSLIIWTLTLVTTIKYVLIALKADNHHEGGIFSLFTLVRRMSRWLIIPAMLGGATLLSDGALTPAVTVTSAIEGLKAVPELSSIYQNQTNVILTTLLILMVLFGLQRFGTGVIGKLFGPVMLVWFSVLGISGLLNSLQHLEILKAINPYYALHLLVSPENHRGIFILGSIFLATTGAEALYSDLGHVGRGNIYASWPFVKVCIILSYCGQAAWILAHKDSGIALNPFFASVPEGLRVYLVILATLAAIIASQALISGSFTLVSEAMRLKIFPLFKITYPGANLGQLYIPVINWSLFAVTSCTVLYFRTSAHMEAAYGLAITITMLMTTILLAYYLIKEGVKPLLASLLMAFFAFIEFIFFLASAVKFMHGGYVVVVLALAIVFVMVIWHAGTMIVAKYVKSLSLNDYKHQIKLLRDDLRFDLYQTNVVYLTNRMKKDLIDRSILYSILDKRPKRAQVYWFVNVRVTDEPYTATYKVDMLETDYIVCVELYLGFRMPQTVPRYLRTIVQDLMESGRLPKQAQDYTITPGREVGDFRFVIIEERVSHARQLSTLERFVMQTKASIKHVTASPMRWFGLQYSEATVEVVPLLLSDVLKLPIKEIKACTKDEKA
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CL071_BOVIN
Sequence: MAQELAAPLSCGQPPGQNITETTTDPWDEGDLRFEPSNSMVHSFSSSSESNLSLSVGYFPCEDTLSCEDTLSCEDSSSEGPSMHFVPPIQGSWRTENTGRLLARRDQIQDDPEQFCKLSITLAWDVDMASNNSDSTTNCDLSGDNKDKHPKEKTQLTLSKLDGLVQKLEKFLENQKDDKDDDSVFPESAQEEDSQLPSSSLPGMAQVSHQEYGSCQDLAKFNPLENEDVNQFPQIHPRLQNQELAKIISKATGSQGTDIAEISSVLPGPPEKEDTHSSTGALSCLNFRWVFRWLRPQVRSSLLGREDPREANERPRELARKKRFSYRSKRIQPQESFELGHPIPPDF
What are the official names of this protein?
Uncharacterized protein C12orf71 homolog.
Protein: HCAB_ECOSM
Sequence: MSDLHNESIFITGGGSGLGLALVERFIEEGAQVATLELSAAKVASLRQRFGEHILAVEGNVTCYADYQRALDQILTRSGKLDCFIGNAGIWDHNASLVNTPAETLETGFHELFNVNVLGYLLGAKACAPALIASEGSMIFTLSNAAWYPGGGGPLYTASKHAATGLIRQLAYELAPKVRVNGVGPCGMASDLRGPQALGQSETSIMQSLTPEKIAAILPLQFFPQPADFTGPYVMLASRRNNRALSGVMINADAGLAIRGIRHVAAGLDL
What is the function of this protein?
Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.
What are the official names of this protein?
3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase, 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase, 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase, CI-dihydrodiol dehydrogenase, Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase, Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase, PP-dihydrodiol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: TTC8_HUMAN
Sequence: MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQEPDPELPVHQAAWILKARALTEMVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPKLAKALFEYIFHHENDVKTIHLEDVVLHLGIYPFLLRNKNHIEKNALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML
What is the function of this protein?
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  Required for proper BBSome complex assembly and its ciliary localization.
What are the official names of this protein?
Tetratricopeptide repeat protein 8, TPR repeat protein 8, Bardet-Biedl syndrome 8 protein.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium.
Protein: XRI1_ARATH
Sequence: MDYGDDDRSSSWNWQVDNYNHQPQSHFSDVPDCTMTEVTLNQEDHSYMFDDENTPVKACSELGYHVTTEDTNRKMEVHSETRSALKRRRMLQFEDQPETSLFSSESFSAILKSSARDDTFDELLPEGSQLIEGFSEDASASSFEGLDLYAEEWYADCLNDAETPMLPDDLNFGSPDVQVDISEYLNVPPETETREVQRPVTRSSPNVIFKGRKSFSRPVSKLPSSIIYPFAFIKPCGVHGGMTLKDINQKIRNPPAKPKAHIEEPAVIQTSAFSGKPVVGKTKIRTEGGKGSITIMRTRG
What is the function of this protein?
Required for mitotic division of the generative cell nucleus and the development of mature tricellular pollen grains, and for male and female meiosis.
What are the official names of this protein?
Protein XRI1, Protein X-RAY INDUCED 1.
Protein: RSMG_YERPY
Sequence: MLKKLDSLLTVAGITLPDQQKHQLIGYVELLDKWNKAYNLTSVRDPQQMLVRHILDSIVVNPHLQGSRFIDVGTGPGLPGIPLAIVRPDAHFTLLDSLGKRVRFLRQVQHELGLNNIELVQSRVEAFTSEPPFDGVISRAFASLQDMLSWCHHLPAKPEGRFYALKGVRPDDELAVLPEDIVLESVIKLDVPELDGERHLIILKSN
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_MOUSE
Sequence: MKTILSNQTVDIPENVEITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRTGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).
What are the official names of this protein?
60S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLB_HAEIN
Sequence: MDRVFIEELTVFAQIGVYDWEQQIKQKLVFDLEMAWDCKQAAETDDVVYCLNYAEVSQAIIDYVESKPFLLIERVAYEVADLLESRYQLQGLKIKLSKPKAVAQARNVGVLIVRGCLK
What is the function of this protein?
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.  Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin.
What are the official names of this protein?
Dihydroneopterin aldolase, DHNA, 7,8-dihydroneopterin 2'-epimerase, 7,8-dihydroneopterin aldolase, 7,8-dihydroneopterin epimerase, Dihydroneopterin epimerase.
What is the protein family that this protein belongs to?
Belongs to the DHNA family.
Protein: T4B_PARTE
Sequence: MARSLTILAIVFAVATARVTKSESPKEILAQVNKDSFGNSILSVLQLQLATGGPVGEIQILLNNIASQLNGDQKKADKVHESDTVAFEKIIADLEQEIAYHQTQIVALSNLRDSTTEALGEAEVEVRVVTSDIANNEKSFADESATRQSQHDTWVRKDAEHVDQMEAIDEASKIVQHLQAGVAFAQLKSRFEKVQAKLMESKHALFKPLINALTQLASKVDNKSIIKILELLAQIRQQLVASRASLLATEERQAANWEVQSSHLSEEHKRLVERKAFLENSIVQFKVTIQEAVEDLEDQTLFLEDAEDSLAIQERWAAEQESQYEAQTFEREQQLEVVERLQEVLTQKLSAASEFLQVREEVF
What is the function of this protein?
Structural protein that crystallize inside the trichocyst matrix.
What are the official names of this protein?
Trichocyst matrix protein T4-B, Secretory granule protein T4-B, TMP 4-B.
What is the protein family that this protein belongs to?
Belongs to the TMP family.
What are the subcellular locations of this protein?
Trichocyst. Note=These are architecturally complex secretory storage granules-docked at the plasma membrane, ready to rapidly respond to an exocytotic stimulus.
Protein: TKT_RHIME
Sequence: MNVSQQIGPRAAASERSMADAIRFLSMDAVEKANSGHPGMPMGMADAVTVLFNRFIRIDPSHPDWPDRDRFVLSAGHGSMLLYSLHHLIGFADMPMAELSSFRQLGSKTAGHPEYGHALGIETTTGPLGQGISTAVGMAIAEQMMAARFGSALCNHFTYVVAGDGCLQEGISHEAIDLAGHLKLRKLVVLWDDNRISIDGSTDLSTSMNQLARFRAAGWDAQAVDGHDPDAVAKAIERARRTRKPSLIACRTRIGKGAASMEGSHKTHGAALGEKEIAATREKLGWPHPPFFVPPEIKAAWEKVATRGRTAREAWEIRLDASRSKKRYEQTVERKLDGEVGDLLARFRGAHRTRATKVATRQASQMALEVINGATALTIGGSADLTGSNLTLTSQTQPISPGNFKGRYLHYGIREHGMAAAMNGIALHGGFIPYGGTFLVFSDYARGAMRLSALMGLPVIYVLTHDSIGLGEDGPTHQPVEHLAMLRATPNLNVFRPADIIETAECWEIAIGEKNTPSVFALSRQALPMLRRTDGNENLSALGAYVLREARGDRDITLLATGSEVEIAVAAAERLQAEERIAAAVVSMPCWEKFEAQDAAYHRQVLGDAPRIAIEAAGRLGWDRWMGPDSAFVGMTGFGASAPAGDLYRHFGITADHVVAEALELLRRACPETPPIGARTGKPVAHIVRSSEEA
What is the function of this protein?
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
What are the official names of this protein?
Transketolase, TK.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: QUEC_YERPE
Sequence: MKRAVVVFSGGQDSTTCLIQALQQYDEVHCITFDYGQRHRTEIDVARELALQLGATAHKVLDVGMLNELAVSSLTRDSIPVPSYDANADGALPSTFVPGRNILFLTLASIYAYQVQAQAVITGVCETDFSGYPDCRDEFIKALNHAIDLGIGRDIAFITPLMWLDKAETWALADYYQQLDLIRHHTLTCYNGIKGDGCGQCAACHLRAKGLASYMANKQQVILNLKQKVGLA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: HEMA_I76A2
Sequence: MEKFIILSTVLAASFAYDKICIGYQTNNSTETVNTLSEQNVPVTQVEELVHRGIDPILCGTELGSPLVLDDCSLEGLILGNPKCDLYLNGREWSYIVERPKEMEGVCYPGSIENQEELRSLFSSIKKYERVKMFDFTKWNVTYTGTSKACNNTSNQGSFYRSMRWLTLKSGQFPVQTDEYKNTRDSDIVFTWAIHHPPTSDEQVKLYKNPDTLSSVTTVEINRSFKPNIGPRPLVRGQQGRMDYYWAVLKPGQTVKIQTNGNLIAPEYGHLITGKSHGRILKNNLPMGQCVTECQLNEGVMNTSKPFQNTSKHYIGKCPKYIPSGSLKLAIGLRNVPQVQDRGLFGAIAGFIEGGWPGLVAGWYGFQHQNAEGTGIAADRDSTQRAIDNMQNKLNNVIDKMNKQFEVVNHEFSEVESRINMINSKIDDQITDIWAYNAELLVLLENQKTLDEHDANVRNLHDRVRRVLRENAIDTGDGCFEILHKCDNNCMDTIRNGTYNHKEYEEESKIERQKVNGVKLEENSTYKILSIYSSVASSLVLLLMIIGGFIFGCQNGNVRCTFCI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: CPFC_STRAW
Sequence: MPEALDASPYDALLLLSFGGPEGPDDVVPFLENVTRGRGIPRERLKEVGQHYFLFGGISPINDQNRALLDALRKDFAEHGLNLPVYWGNRNWAPYLTDTLREMAADGRRRILVLATSAYASYSGCRQYRENLAGALATLEAEGLEVPRVDKLRHYFNHPGFVEPMTEGVLRSLAELPEDVRPGAHIAFTTHSIPTAAADTSGPVEEHGDGGAYVKQHLDVARLIADAVREETGIDHPWQLVYQSRSGAPHIPWLEPDICDHLQELHGAGVPAVVMAPIGFVSDHMEVLYDLDTEAKAKAEELGLPVRRSATVGADARFAAAVRELVVERAAVESGQKVTPCALGALGPSHQLCPVGCCPARAPKPAAAGADSPYA
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
What are the official names of this protein?
Coproporphyrin III ferrochelatase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRM10_CANAW
Sequence: MSDNRPTYDTSSSDEEPSNHFHIQLPQRQLNLQEIRKQNHKKHEKPTIAKQTASNLAKAKKITTGSNHKFGNSINNNNNNANKHLGSSSAGTNRRSLISPTSSTHVSSDDDDDDDDNAAFYGDKLNDNKKLNVFADTKNNLSHFQFNADGIKPKSLHGQGDDSSDDDGNNLDEVEDETHSDFAVLNQNHPPQQYYETDSSDEDEEDDDEVPQTVHKTYSNASSGRSSRLSRKKSMSETTDTRAPIPPTGRRSTNSNHSRESSGRRSTSSGNINSGGGLKGILRKMSLVDSTPVDSTNQDISHSDTFLGRVLNFGTNQGLSGGGLAPGASRVIREEDEGEWNLDEERRVGFAAHENDRDAFEMQPLNYEDLSEEAKQLIQQHVPGAGASNLDHSQQSSAAPSTEITPSQSPNQHLLNEKSNNNENNQQSTTVESSSSTSSPGEDEELARRRASEERKKAENPFYTPNPDLFLRGTNADNQELHQAPNDFLHDMDGDYIAPPKQVQAGVLSSLLRLYQNPQEQKSASSLSRVSTGTSGTALSSFDDSYDSDDYKDSKSSSNVDLQHKLKSGIKGGSKAMFNKAANKLKHHSHTRTNTVETQGSSNSEEFSNDKDEFSNGYDDDNKMNANLPSFQNARPKMPKKKTTEPVQKLKKLRHKQRAERLRITVHIADILQRQRFIMNMCRALMLFGAPTHRLEEYMVMTSRVLEIDGQFIYFPGCMLVSFGDAATRTSEVHLVRCAQGINLSKLADTHKIYKAVIHDLIGVEDASKKLDDLLKSKSRYPPWLCVLFYGLGSLAVTPFAFEGGWLDLPISFGVGLCVGYLQFYVSSISNLYSSVFEVSAAIVVAFIARGIGSIKGGDLFCFSAIAQGSLAIILPGYIILCGSLELQSRNLVAGAVRMFYAVIYSLFLGFGITLGAALYGWIDHNATSANSCASGHAIDEKWRILFVPMFALCLGLINQARWSQVPIMIVIAGIGYIGSFFAGKHFSTVTEFTACIGAFIVGVLGNLYSRIWKGMAVSAMLPAIFVQVPSGIASKSSLISGLNTADQITNKSSSNNGGTVTNDASSLSFGATMVEVSIGISVGLFAAALIIYPFGKKRTGLFAL
What are the official names of this protein?
Pheromone-regulated membrane protein 10.
What is the protein family that this protein belongs to?
Belongs to the ThrE exporter (TC 2.A.79) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL22_ALIFM
Sequence: MEAIAKHRFAGISPQKARLVADQVRGKSVDQALEILTFSNKKAAVLVKKVLESAIANAEHNEGADIDDLNVAKIFVDEGPIMKRIMPRAKGRADRILKRSSHITIVVADR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: PRP_CAPAA
Sequence: VTFVEGGPMKYSLIEGDALANK
What are the official names of this protein?
Pathogenesis-related protein.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
Protein: COWN_HALHL
Sequence: MATADHEATGLDCDHAIRRLLRRIDAHIADEPRDSPVRRYLERELGGREGTEADTRLVVHAQINVVRELFERRSDADGLRLLSNIERECC
What is the function of this protein?
Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO).  Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO.
What are the official names of this protein?
N(2)-fixation sustaining protein CowN, CO weal-nitrogenase.
What is the protein family that this protein belongs to?
Belongs to the CowN family.