PharMolix/UniProtQA huggingface dataset:
Protein: TATA_PROMS
Sequence: MNIFGVGLPEVTVILILALLIFGPKKLPELGKQLGKTLKSLKKASNEFQNEIDQVMNEQDKDESPISIESNQTNEINQEKIDSENSKK
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ELP1_RAT
Sequence: MRNLKLHQTLEFRDIQAPGKPQCFCLRAEQGTVLIGSERGLTEVDPVKKEVKTEISLVAEGFLPEDGSGCIVGIQDLLDQESVCVATASGDVIVCNVSTQQLECVGNVASGISVMSWSPDQELLLLATAQQTLIMMTRDYEVITEQQIHQDDFGEGKFITVGWGSKDTQFHGSEGRPITFPVQMHESALSWDDHRPQITWRGDGQFFAVSVVCSQTGARKIRVWNREFALQSTSESVPGLGPSLAWKPSGSLIASTQDKPNQQDVVFFEKNGLLHGYFTLPFLKDEVKVNDLLWNADSSVLAVWLEDLPKEGSSTLKSYVQLWTVGNYHWYLKQSLPFSTTGKNQIVSLLWDPVTPGRLHVLCQGWRYLCCDWHWTTDRSSGNSADDLANVAVIDGNKVLVTVFQRTVTPPPMCTYRLLIPHPVNQVMSSAHLGNDLAVLDASNQISVYKCDDKPDMDSTVKLGAVGGTGFKVPLRTPHLEKRYRIQFGNKEEEEDVSPLQFRFLTWIEGDAFLAISHSHSSPQSIIHHLTMAGSEGDEEQGQLNVSSSVTVDGVVIGLCCCSKTKSSAVQLADGQVLKYLWESPSSAVEPWKNSEGRPVRFARPCTQMEAAAIGGEECVLGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQCFSLSGASLKMLQAGLCGSQVPSGEILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIHDHNPKVFLENVETFIKQIDSVNHLNLFFTELKEEDVTKTMYPPPVTKSVQVSTNPDGKKVDLICDAMRVAMETINPRKFCLSILTSHVKKTTPELDIVLQKVHELQGKIPFVPESVSAEEALKYLLLLVDVNELFNHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKALGHLSKCGPEYFTECLNLIKDKNLYKEALKLYRPDSPQYQAVSVAYGEHLVQELLYEPAGLVFARCGAHEKALEAFLACGSWQQALCMAAQLQMAKDKVAGLARTLAGKLVEQRKHSEAATVLEQYALDYEEAVLLLLEGSAWEEALRLVYKYDRVDIIETSVKPSILEAQKNYMDFLDSQTATFIRHKNRLKVVRELKSQRPRVHVDHEVAHGRETDLFSETSSIRSGSEMSGRYSHSNSRISARSSKNRRKAERKKHSLKEGSPLEGLALLEALSEVVQSIEKLKDEVHAILKVLFLFEFEEQARELQRAFESTLQLMGTALPDIWTLTGQQSSSTPVLGPSSTVNSIMASYQQQKTCVPVLDAWACLPPKIDQRSQWKLSLLE
What is the function of this protein?
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity).  The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).  Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).  ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity).  May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity).
What are the official names of this protein?
Elongator complex protein 1, ELP1, IkappaB kinase complex-associated protein, IKK complex-associated protein.
What is the protein family that this protein belongs to?
Belongs to the ELP1/IKA1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PAX_I68A4
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFVSPKEAKKQLKKDLKSQGQCAGLPTKVSRRTSPALRILEPMWMDSNRTATLRASFLKCPKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: UCSL_ACRSP
Sequence: MGSLIQTPSTQTAVVTTAEGRHQVAHGRRVPSCGPRSVLVRIKAVALNATDHKMPARVKREGLTSGCDFAGEVVAVGEQANDEPRRCELPRSWAPGDRVFGVVYGSNPGQPEWGAFAEYVEADPIMLCHVPDGWDWETAASVGGSVHGSVALCLFGDGNLALDYSNLKAQADSSSADAVTNQSPKPESFTKEELRKVVLVYGGSTACGTMALQLLRLAGYTPITTCSPRNFGLVESYGAVAAFDYHSETCATEMKTYTRSSLVAALDCLGNTQSAALCYAALGRAGGRYVALEKYPDSVSATRKLVKPSWVMGPVMFGRELQLADGYSQPADLAARAFACDWYPLAERLVHQERLRAHPVTIAGPSPPVGDKWADAILCGLQELRDGSVSASKLVVPVAA
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of UCS1025A, a member of the pyrrolizidinone family that acts as a strong telomerase inhibitor and displays potent antibacterial and antitumor properties (PubMed:29373009).  These compounds share a hemiaminal-containing pyrrolizidinone core fused with a gamma-lactone, giving a furopyrrolizidine that is connected to a decalin fragment (PubMed:29373009).  The polyketide synthase module (PKS) of the PKS-NRPS ucsA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:29373009).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with a 2S,3S-methylproline derived from L-isoleucine by the 2-oxoglutarate-dependent dioxygenase ucsF which converts L-isoleucine to (4S,5S)-4-methylpyrroline-5-carboxylate that is further converted to 2S,3S-methylproline by the pyrroline-5-carboxylate reductase ucsG (PubMed:29373009).  Reductive release of the completed aminoacyl polyketide from the assembly line can form the 3-pyrrolin-2-one structure via an intramolecular Knoevenagel reaction (PubMed:29373009).  Because ucsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase ucsL (PubMed:29373009).  This keto acyclic precursor is the substrate of the Diels-Alderase ucsH, that catalyzes the Diels-Alder cycloaddition (PubMed:29373009).  Oxidation of the 3S-methyl group to a carboxylate by the cytochrome P450 monooxygenase ucsK allows an oxa-Michael cyclization that might involve the reductase/dehydrogenase ucsI and which furnishes the furopyrrolizidine (PubMed:29373009).  The oxidase ucsJ likely plays a critical role in stereoselective reduction of the C5-C6 double bond to afford the required R-configured carboxylate group (Probable).  Further enolization and oxidation at C5 by an unidentified enzyme affords the last intermediate that can undergo oxa-Michael cyclization to yield UCS1025A (Probable).
What are the official names of this protein?
Trans-enoyl reductase ucsL, UCS1025A pyrrolizidinone biosynthesis cluster protein L.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: MNHF2_STAAU
Sequence: MIQTITHIMIISSLIIFGIALIICLFRLIKGPTTADRVVTFDTTSAVVMSIVGVLSVLMGTVSFLDSIMLIAIISFVSSVSISRFIGGGHVFNGNNKRNL
What is the function of this protein?
Expression of the mnh2 operon in E. coli is not able to catalyze Na(+)Li(+)/H(+) antiport.  It does however confer higher growth rates than the control strain at up to pH 9. 5.  The operon may encode an NADH-ubiquinone oxidoreductase.
What are the official names of this protein?
Putative antiporter subunit mnhF2, Mrp complex subunit F2, Putative NADH-ubiquinone oxidoreductase subunit mnhF2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPG_SALG2
Sequence: MAGAKEIRSKIASVQNTQKITKAMEMVAASKMRKSQDRMAASRPYAETMRKVIGHLANGNLEYKHPYLEERDVKRVGYLVVSTDRGLCGGLNINLFKKLLADMKAWSDKGVQCELAMIGSKGVSFFNSVGGNVVSQVTGMGDNPSLSELIGPVKVMLQAYDEGRLDKLYIVSNKFINTMSQVPTITQLLPLPASEDDDLKRKAWDYLYEPDPKALLDTLLRRYVESQVYQGVVENLASEQAARMVAMKAATDNGGSLIKELQLVYNKARQASITQELTEIVSGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YIDD_SHIDS
Sequence: MAPPLSPGSRVLIALIRVYQRLISPLLGPHCRFTPTCSSYGIEALRRFGVIKGSWLTVKRVLKCHPLHPGGDDPVPPGPFDTREH
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RK36_ACOCL
Sequence: MKIRASVRKICEKCRLIRRRGRIIVICYNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y1099_HISS2
Sequence: MPSFDIVSEITLYEIRNAVENANRVLSTRYDFRGVEATIELNEKAETIKVTTESDFQLEQLIEILISSCVKRDIQHNSLDIPADSEHSGKLYSKEIKLKQGIETDMAKKIIKLIKDAKLKVQTQIQGEQVRVSGKSRDDLQATIQLVKNAELGQPFQFNNFRD
What are the official names of this protein?
UPF0234 protein HSM_1099.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: RPOB_SYNSC
Sequence: MSSSAIQVAKTATYLPDLVEVQRASFKWFLDQGLIEELESFSPITDYTGKLELHFIGSEYRLKRPRHDVEEAKRRDATFASQMYVTCRLVNKETGEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEMDKNGRRTYNASVIPNRGAWLKFETDKNDLLHVRVDKTRKINAHVLMRAMGLSDNDVLDKLRHPEFYKKSIDAANDEGISSEDQALLELYKKLRPGEPPSVSGGQQLLQTRFFDPKRYDLGRVGRYKINKKLRLTIPDTVRTLTHEDVLSTLDYLINLELDVGGASLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATHARVNEYGFIETPFWKVEYGVVLKDGDPIYLSADREDEVRVAPGDVATEDDGRISADLIPVRYRQDFEKVPPEQVDYVALSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERALVGTGLETQVARDSGMVPISRVNGTVTYVDANAIVVQDEDGNDHTHFLQKYQRSNQDTCLNQRPIVRCGDPVIVGQVMADGSACEGGEIALGQNVLIAYMPWEGYNYEDALLVSERLVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNVAEESLGNLDEMGIIRVGAFVESGDILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPGTERGRVVDVRIYTREQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLDCRVRIVPFDEMHGAEKSQQTVETFLKEAAKQPGKGWVYDPEDPGKLQLRDGRTGLPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSLGLDIAVYTDEGKEVDLMQDVNPRRSTPSRPTYESLGVADYDED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PYRF_THERP
Sequence: MSFRERLEQTIAQNHSLLCIGLDPDLERFPTGIPRDPEGIVVFNRAIIEATADLVCAYKPNLAFYLQYGAAGIAALATTRQLIPPHIPVILDAKLGDIASTSAAYARAVFETLGFDALTVHPYLGSEALEPFLSTSDRGVFVLVRTSNPGASEIQDLPVGEAGEPLYLWLAERARAWNQRSGNVGLVVGATYPVDLALVRQRCPDLPILAPGIGAQGGDLERAVCAGLTEATAPLLVTVSRSILYADASARFAESARAAARRVRDTIERIRKEVAGQAGHR
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: VAPB1_RICFE
Sequence: MQLFLRINMAQIIRATEFVRSFSDIMNRVYYKGESFDVQKGNHIVARITPAETKPSIAVRDLEEAFKNGPHLDPEDADQFMKDIEEIRRSTRQDIKKLVERWD
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Upon expression in E. coli neutralizes the effect of cognate toxin VapC1, partially inhibits the RNase activity of VapC1 in vitro.
What are the official names of this protein?
Antitoxin VapB1.
Protein: F16PA_NITEU
Sequence: MHTGTTLTQFIIEEQRHIAGASGDFTALLNDIVTAIKTISNAVNKGALIGVMGALDTENVQGETQKKLDVITNEIMIRNNEWAGHLSGMASEEMDDVYSIPSPYPLGKYLLVFDPLDGSSNVDLNISVGTIFSILRSPVPSRAASMEDFLQPGVKQVCAGYALYGSSTMLVLTTGHGVNGFTLDRDIGEFVLTHPNMRIPADTREFAINASNQRFWEAPVQRYVAECLAGSTGPRGRDFNMRWVASMVAEVHRILTRGGIFMYPRDTKDPSKPGRLRLMYEANPMSFIVEQAGGLSTTGYERILDVVPQDLHQRVPVILGSKNEVEVVLEYHNA
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FZD8_MOUSE
Sequence: MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGSGPGPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
What is the function of this protein?
Receptor for Wnt proteins.  Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (By similarity).  The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  Coreceptor along with RYK of Wnt proteins, such as WNT1.
What are the official names of this protein?
Frizzled-8, Fz-8, mFz8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus.
Protein: GLMU_LIGS1
Sequence: MTSKYAIILAAGQGTRMKSKLYKVLHPVCGKPMVDHVLTEIEKNNMDEIVTVVGHGAEMVEKTLGDRTKYALQAEQLGTGHAVLQAEKLLGDKDGMTLIACGDTPLFTAKTFEELFEYHKSKGAVATVLTAHAENPFGYGRIIRNEIGIVEKIVEQKDATVEEATVKEINTGVYCFDNKELFAALHQIKNDNAQGEYYLPDVMEIFQKQGKVVAAYQMKNFEESMGVNDRIALSNATKVMRRRINENLMRQGVTLIDPDTTYIDIDVKVGSDTVIEPGVQLKGKTEIGADCYIGAHSEIIDSVIEDGVKVTSSYIEDAVMHKNSNIGPYSHLRPKAEIGENAHIGNFVEVKKATIGKNTKVGHLTYVGDATLGRDINVGCGTVFVNYDGINKHHTTVGDYSFIGSASNIIAPVNIADHAYVAAGSTITDDIDAHDMGIARGRQVNKKGYFDRYPVAEAARIAEEKAKEE
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_ECO24
Sequence: MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRELLLELMLLADVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGTDPVENARIIISELEKYSQDLAAKPRWLVFNKIDLLDKAEAEEKAKAIAEALGWEDKYYLISAASGLGVKDLCWDVMTFIIENPVVQAEEAKQPEKVEFMWDDYHRQQLEEIAEEDDEDWDDDWDEDDEEGVEFIYKR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCC4_CAEEL
Sequence: MNQDAVAKALLGMAEALRTQDPPKLKMAIKCARSTLSMEISDEMKAICNLQLGKLLFFYTDNFELAKNHLQCAYDKMSAMGTFYTRDKMNAISMLADLHIHYQQWPLTSIKATIRHEITTTRGFPALSNKLMFQLIELMKIDKDVEGAIEMCQLAINSSHADPKMELYFRIAKTLVTYQLMHEEPDISDVTRIGSMIKVMENSTTSDKAHLECIKDFYVCTKLAYMFYEGKSRTSRQLLRQIQKSQTSGETKIHGIRWLGEPSITLLACVMNQICALVQSNTDRVEKYYHLVIKHADEIIFKSTRSPQEPGVVRCINMIKMTTLEMMACCNVLACRPQKTLHNVRDMLEWSNRTSGPLLTRYFTPHIHYILGLQCCYFRQHENAENHFRAAMKKLHKEDITAHNTMALLNLNLAITYLNQLKMADYYEVSENLTAPKISSCSQMLKNNVKLLSAFFAYITNKLNECKLLSHEVLDDSKAEDFFRLHGLGLLLLSLVTDVDEKGVRPTVDWSKKSHDHVVILFSHSLYEKILLAAGYDPKSELMKMVVSEQLASRRMLSVENLTPLVANMPASKLLQWFDGDPFKLLPRDETVL
What is the function of this protein?
Plays an important role in the loading of the cohesin complex on to DNA (By similarity).  Forms a heterodimeric complex (also known as cohesin loading complex) with scc-2/SCC2 which mediates the loading of the cohesin complex onto chromatin (By similarity).  Required for normal development until the fourth larval stage.  Functions cell autonomously to guide migrations during the development of the nervous system.  Participates in the guidance of mechanosensory neuron AVM by a slt-1-independent mechanism.  Regulates chromosome segregation in early embryos.
What are the official names of this protein?
Maternal uncoordinated protein 2, Cohesin loading complex subunit SCC4 homolog.
What is the protein family that this protein belongs to?
Belongs to the SCC4/mau-2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Binds to chromatin from the end of mitosis until prophase. Localizes to the cytoplasm of neurons.
Protein: COXX_THET8
Sequence: MKTPAWSRLAGYAWGVLLWNVLVALFGAYVRATGSGAGCGAHWPTCNGEVIPRAPQVETLIEFTHRATSGLAFLSVLALFLWALRAFPKGHPARFGAGLALFFMVTESLVGASLVLFGWTADNVSRERAVVQMVHLANTYFLLAALALTAWWASGGGPLRLRGQGAVGLALFLGLLALLFLGMSGAVTALGDLLFPVGSTLEALERSLTPGEHFLVRLRVLHPLIAVSVGLYVVFAGYLVAHLRPSPLTRRLAQGLAYLYGAQLLAGLINVALKAPVWMQILHLLLAYAIWLLFVFLATSALERGAKRVELGEGGEAVHRGTGGATWRDYLALTKPRVISLLLFTALFGALIAAKGWPGLGVFLAVALGGYMMAGAANAINMVVDRDIDARMKRTAKRPTVTQRVSSRDALLFAFALAVLGFAVLWWGANLLAATLALMGLIWYVLVYTLYLKRRTWHNIVIGGAAGAFPPLVGWAAVTGELSLFAWYLFALIFFWTPVHFWALALMIQDDYRAVGVPMLPVVLGERATVIQIALYALLTALISLMPLLLGELGLLYLAASLLLNALLLLKSLALYRRPERRTAVSLYKYSMLYLALLFAAMAVDRAV
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS9_ECOLU
Sequence: MAENQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRSELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RS14_PSEE4
Sequence: MAKKSMKNRELKRQLTVAKFAKKRAELKATIVNLNASPEERFAAVVALQKQPRDASASRLRNRCRLTGRPHGVYRKFGLGRNKLREAAMRGDVPGLVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: HUTU_PSEU2
Sequence: MTENNQHLKQDWTRHREGVVRAARGTQLTAKSWLTEAPLRMLMNNLDPEVAENPNELVVYGGIGRAARNWECYDKIVESLTQLNDDETLLVQSGKPVGVFKTHSNAPRVLIANSNLVPHWASWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYDGNLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRIKTRYVDEQAADLDDALARIAKYTAEGKAISIALCGNAAEILPEMVRRGVRPDMVTDQTSAHDPLNGYLPKGWTWDEYRARSVSEPASVVKAAKQSMAEHVEAMLAFQQAGIPTFDYGNNIRQMAKEVGVTNAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPQDIYKTDAKVKELIPDDEHLHNWLDMARERISFQGLPARICWVGLGQRARLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETESMRDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVIVCDGTDEAAERIARVLHNDPATGVMRHADAGYDIAIDCAREQGLNLPMIGR
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_ECOHS
Sequence: MTTNTHTLQIEEILELLPHRFPFLLVDRVLDFEEGRFLRAVKNVSVNESFFQGHFPGKPIFPGVLILEAMAQATGILAFKSVGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVTFEKTRRGLTRFKGVALVDGKVVCEATMMCARSREA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.