PharMolix/UniProtQA huggingface dataset:
Protein: PIAS3_RAT
Sequence: MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPSPLASIPPTLLTPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQEGNQSENKKRVEVIDLTIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMGTLGSDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYSPSVITSLDEQDTLGHFFQFRGTPPHFLGPLAPTLGSSHRSATPAPAPGRVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDVISLD
What is the function of this protein?
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.  Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway.  The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.  Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.  Sumoylates CCAR2 which promotes its interaction with SIRT1.  Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity).
What are the official names of this protein?
E3 SUMO-protein ligase PIAS3, E3 SUMO-protein transferase PIAS3, KChAP, Potassium channel-associated protein, Protein inhibitor of activated STAT protein 3.
What is the protein family that this protein belongs to?
Belongs to the PIAS family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules.
Protein: UBP54_MOUSE
Sequence: MSWKRNYFSGSRGSVQGMFAPRSSMSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKGIFNQFQCSSEKVLPSDTLRSALAKTFQDEQRFQLGIMDDAAECFENLLMRIHFHIADETKEDICTAQHCISHQKFAMTLFEQCVCSSCGATSDPLPFIQMVHYISTTALCNQAICMLEKREKPSPSMFGELLQNASTMGDLRNCPSNCGERIRIRRVLMNAPQIITIGLVWDSEHSDLAEDVIHSLGTCLKLGDLFFRVTDDRAKQSELYLVGMICYYGKHYSTFFFQTKIRKWMYFDDAHVKEIGPKWKDVVTKCIKGHYQPLLLLYADPQGTPVSAQDLPPHAQFLPYTKTCYDSEDSGHLTDSECNQKHTSKKGSLVERRRSSGRVRRKGDEPQASGYHSEGETLKEKQAPRNASKSSSSSRLKDFKETVSNMIHSRPSLASQTSAGSPCVGRAGDQLDKIPPRNFPLQARGWETESTSSEAKSSSSSKYRPTWRPKRESLNIDSIFSKDRRKHCGYTQLRTFPEDAAKEFTPDEVSKPTANDIKDGGSRSQHKLWGTARPGSHLLEQHPRLIQRMESGYESSERNSSSPVSLDAAPPDSVNVYRDQSTKRPVGFVPSWRHIPKSHSSSILEVDCTAPMTSWTKTQPLSDGEVTSRSELDELQEEVVRRAQEQELRKKREKELEAAKGFNPHPSRYMDLDELQNQGRSDGFERSLQEANSIFEESLHLEQKGDCAAALALCNEAISKLRLTLHDASSSTHSRALVDKKLQISIRKARSLQDRMQQQASSQQPVQPSASLPSQGGALPQPTSEQPITLQVLLNQEAQLEPCKDTELGATSSFFHSPASCPELHSSLIPESPVSSVSQHSPPGTSSLKLLTSFEVDSVNRSAFHRQGLPKATGRTEMNSQHECLPLDALEDRLQGHREDNSCCSKFPPREGRDIAQDQLFEGKKNPADISMGMPWSYSTGEATSERVIYSLNSPSSSSAQPSIPPYSSCHPITSAASSPVLHAADPMQKLNQHVQAQSLQTSLTSKVVRSSEEPYRLEFPSTKGLVRSLAEQFQKMQNTSTRDVIGSQDRSLPNGVRKSSSPSDFMPPLSQGPGREHCRWVKQPRSPDGRERPPCWEDPAAHPPLSMGSGLPDGETSRTAQPRLAEPDMYQGKLPQVTDIRSKELGSSVNLGTSLPLDSWVNVTRLCDSQVKPSAPGPGDKSSSHDSHPRATCLERSPILLHPHWDQDTEQETSELESLYQASLQASSHTAYSDWRSQDVAWQPLSLAGSADGMGRRLHSAPGLDLSKPLTAEMEHVLYEPSTVPVSQDSSNVRKKTLETGHHCSSSSSLPVIHDPPVFLLDPKLYPPQPQFLSPDVLMPSMAGEPYRPPGTSRSVHQFLAMCDRDETPQGVKYTGRTLNYRSLPHRSRTDASWGPGSETNQHIGARVLTMPACKPQLTYTATLPERHQGLQVPHAQSWGNLFHSPSHPSAVHPGSPPSSNLHVPLRSTWNSGPVLGSRTPGPRRIDMPPDDDWRQSSYPSQDRHRSPGEERIMFALSNAAGREQNRVRFLQHSRW
What is the function of this protein?
Has no peptidase activity.
What are the official names of this protein?
Inactive ubiquitin carboxyl-terminal hydrolase 54, Inactive ubiquitin-specific peptidase 54.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: FENR2_LISW6
Sequence: MDEKTKIYDITIIGGGPVGLFAAFYAGMRNASVKIIESLPQLGGQLSTLYPEKYIYDIPGYPAVRAQELVNNLIQQMKPFDPTIALEEAVISVEKQVDGTFEIITKKDTHYSKAIVITAGNGAFEPRRLDLPEAEQYEGKNIHYFINDLSRFSGRRVAVCGGGDSAVDWALMLEKVASSVSIVHRRNAFRAHEHSVNNLEKSSITIKTPFIPTEVLGNGDKLTHITLQEVKGDTSETLEIDDFIINYGFVSSLGPIKNWGLELERNSIIVNSKMETSIPGIYCAGDICTYDGKVKLIATGFGEAPTAVNNAMNFIDPKTRVQPMHSTSLFE
What are the official names of this protein?
Ferredoxin--NADP reductase 2, FNR 2, Fd-NADP(+) reductase 2.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: NODA_BRASN
Sequence: MNIAVSTTAEGLSMRPQVQWRVRWESELCLADHVELSEFFRKSYGPTGAFNAQPFENNRSWAGARPEVRVIGYDARGIAAHIGLLRRFIKVGEVDLLVGELGLYAVRPDLEGLGITHSMRVMYPVLHELGVPFGFGTVRPALEKHITRMLGRQGLARLLSGIRVRSTHPDVYLNLPTTRSDDALVLVLPIVRSIGEWPTGTVIDRNGPEL
What is the function of this protein?
N-acyltransferase required for nodulation.  Acts in the production of a small, heat-stable compound (Nod) that stimulates mitosis in various plant protoplasts (By similarity).
What are the official names of this protein?
Nodulation protein A.
What is the protein family that this protein belongs to?
Belongs to the NodA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_KOSOT
Sequence: MIKRRDRKELRRKRHLRVRSKIKGTPERPRLAVYRSERHIYAQIIDDIAGRTIVSASTVDKELREKLTKTWNQEAAKEVGKLIAKRAAEKGIKKIVFDRGGFKFHGRIKSLADAAREAGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: M23N_CONTS
Sequence: MMSKLGVLLTICLLLFPLTAVQLDGDQPADLPELRAQDFAPERSPWFDPVRRCCSQDCRVCIPCCPY
What are the official names of this protein?
Conotoxin TsMMSK-B022.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ALMT1_WHEAT
Sequence: MDIDHGRESDGEMVGTIASCGLLLHSLLAGLGRRAAGFARKVGGAAREDPRRVAHSLKVGLALALVSVVYFVTPLFNGLGVSAIWAVLTVVVVMEYTVGATLSKGLNRALATLVAGCIAVGAHQLAELAERCGDQGEPIVLTVLVFFVASAATFLRFIPEIKAKYDYGVTIFILTFGLVAVSSYRVEELIQLAHQRFYTIAVGVFICLCTTVFLFPVWAGEDVHKLASGNLDKLAQFIEGMEFNCFGENSVANNFGGKDSPQMHKSVLNSKATEDSLCTFAKWEPRHGQFRFRHPWSQYQKLGTLCRQCASSMEALASYVITTSKTQCPAAANPELSCKVRKTCGEMSLHSSKVLRDLAMATRTMTVPSPVNITMATAVKAAESLRSELAENTALLQVMHVAVTATLLADLVDRVKEIAECVDVLARLAHFKNPEDTKNVVVSTVSRGIDEPLPDVVIL
What is the function of this protein?
Malate transporter critical for aluminum tolerance.  Permeable to chloride, nitrate, sulfate and malate.
What are the official names of this protein?
Aluminum-activated malate transporter 1, TaALMT1.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS20_ECOBW
Sequence: MANIKSAKKRAIQSEKARKHNASRRSMMRTFIKKVYAAIEAGDKAAAQKAFNEMQPIVDRQAAKGLIHKNKAARHKANLTAQINKLA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: GATB_GEOSM
Sequence: MKYQVVIGLEVHTQLTTNTKIFCGCSTRFGAEPNSQTCPVCLGLPGALPVLNRQVVEYAIRAGLATNCSITQRNVFARKNYFYPDLPKGYQISQFDLPICQHGHLDIDLEGERKRIGITRIHMEEDAGKLVHADIPGVDDSCVDLNRACTPLLEIVSEPDMRSPDEAIAYLKKLHQIVMYLGICDGNLEEGSFRCDANVSLMPVGSNVFGTRAELKNINSFKFIKQAIEYEIERQAEILDDGGKVIQETRLFDPNTGTTRSMRGKEEAHDYRYFPDPDLVPVIISDDWIERVRGELPELPEAKRARFMSELSLPEYDAEVLAASRELAQYFEDTFALFPQAKTVSNWVMGEVTRALNDDNNRSIAECPVTPALLADLLKLMEKGTISGKIAKTVFDEMYKTGKAPEKIVEEKGLVQVSDTGAIEAMIDEVLEKNAGQVAEYRGGKETLFGFFVGQVMRASKGKANPGVVNEMLLKKLQG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: Y1378_CROS8
Sequence: MAGHSKWANTKHRKAAQDAKRGKIFTKIIRELVTAARLGGGDPGSNPRLRAAIDKALSNNMTRDTLNRAIARGVGGDEDANMETIIYEGYGPGGTAVMVECLSDNRNRTVAEVRHAFSKCGGNLGTDGSVAYLFSKKGVISFEAGDEDTIMEAALEAGAEDVVTYDDGAIDVYTAWEEMGAVRDALEAAGLKADNAEVSMIPSTKADMDAETAPKLLRLIDMLEDCDDVQEVYHNGEISDEVAATL
What are the official names of this protein?
Probable transcriptional regulatory protein ESA_01378.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPX_STREE
Sequence: MTTFLGNPVTFTGSQLQVGDTAHDFSLTTPNLEKKSLADFAGKKKVLSVI
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: M1_I77A4
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDKAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVATTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRAIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: NDHN_PROMT
Sequence: MPLLLSGQKFRTDLESFGCLAILSPLEGGAETRLLRRLRASGYQTQVTSARGLGDPVVFLTQLHGIRPPHLGHQNVGRNGALGEVQQVIPQLNELLVEDKPLVLWLLEGQVLSKSELLAINNLCQKEPRIKIVIEMGGARSIKWQPLNEFINKD
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit N, NAD(P)H dehydrogenase I subunit N, NDH-1 subunit N, NDH-N.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhN subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NRDR_STRP8
Sequence: MRCPKCNYHKSSVVDSRQAEDGNTIRRRRECEQCHTRFTTFERVEELPLLVIKKDGTREQFSRDKILNGVVQSAQKRPVSSTDIENVISRIEQEVRTTYENEVSSTAIGNLVMDELAELDEITYVRFASVYKSFKDVDEIEELLQQITNRVRGKKKRLNNDETN
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: KPRS_CAMJE
Sequence: MRGYKIFSGSANVEFARQVSKYLSLPLSDAGVKRFSDGEISVQIDESVRGKDVFIIQSTCAPTNDNLMELLILTDALRRSSANSITAIIPYFGYARQDRKANPRVPITAKLVANLIQAAGIDRVATIDLHAGQIQGFFDIPVDNLYGSIVFNDYIKAKHFKNAIIGSPDIGGVARARSVAKHLGLDIVIVDKRREKANESEVMNIIGDVKDKEVILVDDIIDTAGTIVKAAEALKEKGAKSVMACCTHAVLSGKAYERIASGVLDELVVTDTIPLKEQLPNIKVLSVTPVFAEVIRRVYHNESVNSLFI
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE4_HPV6B
Sequence: MADDSALHKKYPFLNLLHTPPHRPPPLCPQAPRKTQCKRRLGNEHEESNSPLATPCVWPTLDPWTVETTTSSLTITTSTKDGTTVTVQLRL
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4, E1^E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: ACSA2_NOVHA
Sequence: MIYRAILKRLRLEQLARVPAVSAASPFVMMAVGVFLMLMAGGVTISTTSQAFVTCGTVGLFLLLKGRKGRGVTCFLMMLSLLVSLRYMVWRLTTTLELHSPLQAALSLLLVAAELYALLTLCLSYFQMSWPLDRKPLPLPADTTDWPVVDVYVPSYNEELSLVRSTVLGALAIDWPADKLNVYILDDGRRKSFHAFAMEAGAGYIIRDQNNHAKAGNLNHALRVTEGEYVVIFDCDHIPTRGFLKKTIGWMMADPKLALLQTPHHFYSPDPFQRNLATGQNVPPEGNMFYGLVQDGNDFWDATFFCGSCAAIRRSAVLGIGGFATETVTEDAHTALKMQREGWHTAYLRQPLAAGLSTERLMLHIGQRVRWARGMLQIMRLDNPLLGSGLRWQQRLCYLSAMSHFLFAIPRLVFLASPLAFLFLGQNIIAASPFAILVYAFPHVFHSIGTLSRVEGRWRYSFWSEIYETTLALFLVRVTIMTLLNPRKGEFNVTDKGGLLQSEYFDLNAVYPNVILAVILALALVRGIGGMMWEYHDRLALQSFALNTLWVAVSLIIVLASIAVGRETRQIRHKPRVRATLPITLIDEHGQHYHAHTSDISLGGIAARLSTEHALPTQTRVTMLYHNEKDGIDVRIPAVILFSKPGQLHLQWSVDDLDVERQIVEFMFGRNDAWSNWGDFQPDRPVRSFLMVLRSIGGLFRRGQRLFRWQAPQEAPLAESEHVEEEKLEKKSLVLKPVRRSARHGATASLIVLLGLPAAIAPSLAQAPSRATPVATEQGATPVEPPPVNAPPPPSLPQPPGTLPTPPQIAPASAGELLPAATAVSLPTGPATQQMRERLSERTGVSPASPFGDTNTGALPADPSAPPIDPADAARVADGEITRTSTFRDLGLATGPLTLRGFSPLQGLDVIVPANRVVTRARITLSGALSPSLLPEASAVSVTLNEQYVGTIRVDPEHPRFGPITFDIDPLYFTGDNKLNFHFAGEYRRDCNDLYNEVLWARISDFSTVTLTTTRIAPDRKLSYLPAPFYDPNLRTPLRVPVVMPNPDAHGMLKASALVASWFGKLADFRKVSFPVSTTIPASGNAIAIGENLPIDARGTRPTGPTLSEVENPNDRLGTILVLTGRNAQEVEVAARVLAFSSDTLGAVGTKVVNDVTLQPRHPYDAPAFVPTDRPVRFGELVAASDLQGGGFAPPVMALPFHLPPDLYSWRNRPYPIDLWVRTPGGPVVDLETSRLDVHLNNNYLDSFTLKPPSLWAAWSERLVNQHAGAVEHAAALPPWLLFGQNQLKFSFDARPIDRGVCRRTPDDIHMSVDSDSWLDFRRGYHFARLPNLSYFAEAAFPFSRMADLSETTVVVPHHIDAGTAGTFMDLMGFFGATTWYPASGVQVADINDLSEHPPQGDILILATAGDAPKFEELLTRAPYELTDGHIRVGQHMGLQGIWYLFQDHDHAGLQDGVQANLNAPIAGAGVLLGAQSPYRSDRSVVALMGDTPSRMHDLVMGLRSKEDVPRIQGDLVLRNGDRLTSYRTAPTFTMGSLPWWMWLDWYLGTRPLTLYVLGLVGAGLVAAAAVRLLRRRAQHRLEEAARVKDTTDASH
What are the official names of this protein?
Cellulose synthase 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the AcsB/BcsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSL7_STAAE
Sequence: MKLKTLAKATLALGLLTTGVITSEGQAVQAKEKQERVQHLYDIKDLHRYYSSESFEFSNISGKVENYNGSNVVRFNQENQNHQLFLLGKDKEKYKEGIEGKDVFVVKELIDPNGRLSTVGGVTKKNNKSSETNTHLFVNKVYGGNLDASIDSFSINKEEVSLKELDFKIRQHLVKNYGLYKGTTKYGKITINLKDGEKQEIDLGDKLQFERMGDVLNSKDINKIEVTLKQI
What is the function of this protein?
Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5 (PubMed:23797068).  Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases.  In turn, prevents C5a-mediated neutrophil migration (By similarity).
What are the official names of this protein?
Staphylococcal superantigen-like 7.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AZAK_ASPNA
Sequence: MTVHPPAVADETSPLLPSQDGPGHNGIVPAATKPKELQSSMSQVALLCCARAIDPLAFFTIFPFVNQMIADTAGIDEADVGFYSGIIESLFSVTQMMLMIPWARAADRMGRKPVLILSLAGLSVSSALFGFSRTLGQMVFFRCLAGTFGGTVVTVRVMISENSTPDTQARAFSYFSLANTIGTVIGPLLGGALCRPGGVFRHYPYALPTVAAGAFGVTVTVACLMFVNETRKPADHTPHETASPTWTSAKILRSQGVLPVLYIHGHSMMLAFAYTAVSPVFYFTSPRLGGYGFSPFYISLFLGGSGIAQTIWLVLVYPPLHKRLGTGNILRGLCFVWIIFLAATVGASVLHRHCEMVAFWILAPLALVLGSSVAMQLTAMQLALDSVSPSPAALGTLNAMSLAIISFLRAVAPAMFTSMYASTLKLSSPGFYTFWLVLGGLVLVLAFTLRWLPEQVEKAPRKLGRSSA
What is the function of this protein?
Efflux pump that might be required for efficient secretion of azaphilones (PubMed:22921072).
What are the official names of this protein?
Efflux pump azaK, Azaphilone biosynthesis cluster protein azaK.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DCUP_PSE14
Sequence: MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRASAGDFMSLCKNPQFACEVTLQPLDRYPLDAAILFSDILTIPDAMGLGLYFETGEGPRFKKTVSTLADIEALPIPDAQKDLGYVMDAVSTIRRELNGRVPLIGFAGSPWTLATYMVEGGSSKDFRKSKAMLYDNPQAMHLLLDKLAQSVTAYLNGQILAGAQAVQIFDSWGGSLSSAAYQEFSLAYMRKIVNGLIREHDGRKVPVIVFTKGGGLWLESIADIGADTLGLDWTCDIGEARQRVGSKVSLQGNMDPTVLYARPEAIRQEVARILASYGSGTGHVFNLGHGITPEVDPANAGAFINAIHELSAQYHQ
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PARE_MYCCT
Sequence: MAENKKYDESAIQVLEGLEAVRKRPGMYIGSTDNKGLHHLVWEIVDNAIDEALAGYCTQIDVILEKDNSITVIDNGRGIPTGMHKTGKPTPEVIFSVLHAGGKFDSTAYKSSGGLHGVGSSVTNALSKRFKAIIYRDKKIHEIEFKNGGKLEKPLTFINTTYKTGTTINFLPDDTIFSNAKFNFSLISERLKESALLNSGLKITLSDLISNRYVEYQFQDGLVEFVKELVDDKTPVTDIITINNESKNIIVEIALQYTEDDNEIILGFANNVKTIDGGTHLVGFKSGLIRAINDYAKDQKILKDKTKLDSNDLREGLVAIVTVKIPENLIEYEGQTKSKLGTSDAKTVVEQIVYEFMSYWLIENKVLANKVIENALNAQKARIAAKQARQAIKSVKGKKNVNKLMLGKLTPAQGKKRELNELYLVEGDSAGGSAKSGRDRNFQAILPLRGKVINSEKAKLVDLLKNEEIQSIINAIGAGVGKDFDISDINYGKIIIMTDADTDGAHIQTLLLTFFYRHMKDLIIHKKVYIALPPLYKITFNDKSFIYLWDEEELNKFNKTNTKKYEIQRYKGLGEMNADQLWQTTMDPKNRKIIQVTISDGLLAERMFKTLMGDDVEKRKLWIQENVKFTLEDDQIQIIEMEK
What is the function of this protein?
Topoisomerase IV is essential for chromosome segregation.  It relaxes supercoiled DNA.  Performs the decatenation events required during the replication of a circular DNA molecule.
What are the official names of this protein?
DNA topoisomerase 4 subunit B, Topoisomerase IV subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMK_SACS2
Sequence: MIKVSAPGKILWIGSYSVVFGGISHVIAVNKRVSCSLREIKEKDSLIFHTSYGHFKNSGNELINSVLDTFRERLSQLPQGYEIDLYNDKEFIIDGKKTGLGSSSAATVSLTACLYYAIHGKLDLFEIHKLAQIANYKRQKGIGSGFDIASAVFGSIVYKRFTDLDKMDFYFEKLNLGNYDMMLGFTGKSSETVGLVRKFVEKSNLDDFKEIMRLIDEENYMAIKLIKLNKLDEAVEHIKLGRKYLNYIAERIVGVKLVSKMEEELIKIAEEEGALVALSPGAGGGDSIFALGNDLNRVREAWSKRGIFIIDVKEDEGLRLESN
What is the function of this protein?
Catalyzes the phosphorylation of (R)-mevalonate 5-phosphate (MVAP) to (R)-mevalonate 5-diphosphate (MVAPP).  Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
What are the official names of this protein?
Phosphomevalonate kinase, PMK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family.
Protein: CAP10_ARATH
Sequence: MSGGGGSQSSLRRYLGAIKDTTTVSLAKVNSDYKELDIAIVKATNHVERPSKERYIRAIFMAISATRPRADVAYCIHALARRLSRTHNWAVALKTLIVIHRALREVDQTFHEEVINYSRSRSHMLNMSHFKDDSGPNAWAYSAWVRFYALFLEERLECFRVLKYDVEVDPPRTKDLDTPDLLEQLPALQELLFRVLDCQPEGAAVQNHIIQLALSMVISESTKIYQALTDGIDNLVDKFFDMQRNDAVKALDMYRRAVKQAGRLSEFFEVCKSVNVGRGERFIKIEQPPTSFLQAMEEYVKEAPLAAGVKKEQVVEKLTAPKEILAIEYEIPPKVVEEKPASPEPVKAEAEKPVEKQPDLLSMDDPAPMVSELEEKNALALAIVPVSVEQPHSTTDFTNGNSTGWELALVTAPSSNEGAAADSKLAGGLDKLTLDSLYEDAIRVSQQQNRSYNPWEQNPVHNGHMMHQPFYASNGVAAPQPFQMANQNHQTFGYQHQNAGMMMGPVQQPYQQQQQNMNNPFGNPFVSNGNPQQPQGYNPYPRYM
What are the official names of this protein?
Putative clathrin assembly protein At5g35200.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalized with clathrin in the Golgi area.
Protein: NIKR_SALTI
Sequence: MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRGALAQEATQEHGTQGFAVLSYVYEHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRGVRHGHLQCLPKED
What is the function of this protein?
Transcriptional repressor of the nikABCDE operon.  Is active in the presence of excessive concentrations of intracellular nickel.
What are the official names of this protein?
Nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: PURA_STRP8
Sequence: MTSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDGKKFKLHLIPSGIFFPQKISVIGNGVVVNPKSLVKELAYLHDEGVTTDNLRISDRAHVILPYHIQLDQLQEDAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFAERLRINLAEKNRLFEKMYDSTPLDFDAIFEEYYAYGQEIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVLSGLDAVKICVAYDLDGERIDYYPASLEQLKRCKPIYEELPGWQEDITGVRSLDELPENARNYVRRIGELVGVRISTFSVGPGREQTNILESVWASI
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.