PharMolix/UniProtQA huggingface dataset:
Protein: RECO_STRP2
Sequence: MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSKLAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQDNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAFDFSFKYGTCLCPEHYHEDERRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQFMDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RRP36_PICGU
Sequence: MNRRVRPQYDDSDESGVEYESGHDEMEEISFGALNSAQKKIKNEDEKKWSRRNNSNNDSDGEEGDFFESDSDGPPEESSSKTSDQKTRSKHAPAEASAKRPVSRIRQIPGLETKDNSKFGDIRFDPAFGKANEERIRKDYSFLNEYRQSELEQMQRMLKDKKLSRSMSPRERQELELQTQSLRSRLDSMKNKDLEAQVLAEHKKQQKEKWKSGQQAAPYFLKKSEKRKLLQKAKFESMKAPQREKVMERKRKRRLGKEMRQLEFGRK
What is the function of this protein?
Component of the 90S pre-ribosome involved in the maturation of rRNAs.  Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
What are the official names of this protein?
rRNA biogenesis protein RRP36, Ribosomal RNA-processing protein 36.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: LGT_STRPB
Sequence: MINPIALKCGPLAIHWYALCILSGLVLAVYLASKEAPKKGISSDAIFDFILIAFPLAIVGARIYYVIFEWSYYVKHLDEIIAIWNGGIAIYGGLITGALVLLAYCYNKVLNPIHFLDIAAPSVMVAQAIGRWGNFINQEAYGKAVSQLNYLPSFIQKQMFIEGSYRIPTFLYESLWNLLGFVIIMMWRRKPKSLLDGEIFAFYLIWYGSGRLVIEGMRTDSLMFLGIRISQYVSALLIIIGLIFVIKRRRQKGISYYQE
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: APAH_SALEP
Sequence: MATYLIGDVHGCYDELIALLQQVEFTPDTDTLWLTGDLVARGPGSLDVLRYVKSLGNSVRLVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQVDEEKKLVMAHAGITPQWDLQTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELSGLARLRFITNAFTRMRYCFPNGQLDMYSKASPENAPAPLKPWFAIPGPVSEAYSIAFGHWASLEGKGTPEGIYALDTGCCWGGELTCLRWEDKQYFVQPSNRQMDMGEGEAVNA
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: GLAH_CITK8
Sequence: MNALTAVKTNADSVTRSDAGFTFAPSVQSPRLLELTFSAKTTAQFLQQVEQWPVQALEYKSFLRFKVGQILDALCGNQLQPLLIKTLLDRAEGALLINAEGIDNVEQADEMVKLATAVAHLIGRSNYDAMSGQYYARFVVKNVDNSDSYLRQPHRVMELHNDGTYVEEVTDYVLMMKIDEQNMAGGNSLLLHLDDWEHLERFFSHPLARRSMRFAAPPSKNVSHDVYHPVFDVDQQGRPVMRYIDQFVQPKDFEEGVWLSDLSDALETSKNILSVPVPVGKFLLINNLFWLHGRDRFTPHPDLRRELMRQRGYFAYSTRCYQTHQ
What is the function of this protein?
Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG).  Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Glutarate 2-hydroxylase, G-2-H.
What is the protein family that this protein belongs to?
Belongs to the glutarate hydroxylase family.
Protein: YRKL_BACSU
Sequence: MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFIIDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELLLAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVKNSAERLVDYLKAEH
What are the official names of this protein?
Uncharacterized NAD(P)H oxidoreductase YrkL.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family.
Protein: BRD7_HUMAN
Sequence: MGKKHKKHKSDKHLYEEYVEKPLKLVLKVGGNEVTELSTGSSGHDSSLFEDKNDHDKHKDRKRKKRKKGEKQIPGEEKGRKRRRVKEDKKKRDRDRVENEAEKDLQCHAPVRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDGTDTSQSGEDGGCWQREREDSGDAEAHAFKSPSKENKKKDKDMLEDKFKSNNLEREQEQLDRIVKESGGKLTRRLVNSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNKVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYPYVMADSLLDVLTKGGHSRTLQEMEMSLPEDEGHTRTLDTAKEMEITEVEPPGRLDSSTQDRLIALKAVTNFGVPVEVFDSEEAEIFQKKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMHLAEQVTNNLKELAQQVTPGDIVSTYGVRKAMGISIPSPVMENNFVDLTEDTEEPKKTDVAECGPGGS
What is the function of this protein?
Acts both as coactivator and as corepressor.  May play a role in chromatin remodeling.  Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity.  Induces dephosphorylation of GSK3B at 'Tyr-216'.  Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity).  Transcriptional corepressor that down-regulates the expression of target genes.  Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac).  Binds to the ESR1 promoter.  Recruits BRCA1 and POU2F1 to the ESR1 promoter.  Coactivator for TP53-mediated activation of transcription of a set of target genes.  Required for TP53-mediated cell-cycle arrest in response to oncogene activation.  Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters.  Inhibits cell cycle progression from G1 to S phase.
What are the official names of this protein?
Bromodomain-containing protein 7, 75 kDa bromodomain protein, Protein CELTIX-1.
Protein: THIC_METHJ
Sequence: MSIVEDARKGIITEEMKVVAAQEGVTEDFIRRGIASGQIVIPVSPYRKVKLCGIGGGLRTKVNCSVGTSTDIVDVDMEVEKVKAGERAGADTIMELSTGGDFVEIRRRCIEATTLSVGSVPLYQAFIEAARKDGAVIHMREDDLFRITEEQAKLGTNFMAIHTGVNRITLERLQRQGRHGGLCSRGGAFLTAWMLHNDKENPLYAEFDYLCEILKEHEVTLSTGNGMRAGAVHDATDRAQIQELIINAELGDRAHEMGIQVIVEGPGHVPLDQIETNVRLMKRMSGNKPFYMLGPIVTDIAPGYDDRVSAIGAAMSSMHGADFICYVTPAEHLALPNPEEVYEGVISSRIAAHVGDMIKLNKRDQDLAMGHARRDLDWEAQFNLAINPARARQIRNERASADADACTMCGDYCALKIANKVIKKLD
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: AB29G_ARATH
Sequence: METLSRSLSKSLGELLASNSNNHFSRRSGSTIDDHDEEALKWAALEKLPTFARLRTTIIHPHEDLVDVTKLGVDDRQKFIDSIFKVTEEDNEKFLKKFRNRIDRVRIKLPTVEVRFEKVTIEANCHIGKRALPTLPNAALNIAERGLRLLGFNFTKTTKVTILRDVSGIIKPSRMTLLLGPPSSGKTTLLLALAGKLDQSLKVTGRVTYNGHGLEEFVPQKTSAYISQNDVHVGVMTVQETLDFSARCQGVGTRYDLLSELVRREKDAGILPEPEVDLFMKSIAAGNVKSSLITDYTLRILGLDICKDTVVGDEMIRGISGGQKKRVTTGEMIVGPTKTLFMDEISTGLDSSTTYQIVKCLQEIVRFTDATVLMSLLQPAPETFELFDDIILLSEGQIVYQGPRDHVLTFFETCGFKCPDRKGTADFLQEVTSRKDQEQYWADSKKPYSYISVSEFSKRFRTFHVGANLEKDLSVPYDRFKSHPASLVFKKHSVPKSQLFKVCWDRELLLMKRNAFFYITKTVQIIIMALIASTVYLRTEMGTKNESDGAVYIGALMFSMIVNMFNGFAELALMIQRLPVFYKQRDLLFHPPWTFSLPTFLLGIPISIFESVVWVTITYYMIGFAPELSRFLKHLLVIFLTQQMAGGIFRFIAATCRSMILANTGGALVILLLFLLGGFIVPRGEIPKWWKWAYWVSPMAYTYDALTVNEMLAPRWINQPSSDNSTSLGLAVLEIFDIFTDPNWYWIGVGGILGFTVLFNILVTLALTFLNPLEKQQAVVSKENTEENRAENGSKSKSIDVKRGMVLPFTPLTMSFDNVNYYVDMPKEMKEQGVSKDKLQLLKEVTGVFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIEGDIRISGFPKRQETFARISGYCEQNDIHSPQVTVKESLIYSAFLRLPKEVTKYEKMRFVDEVMELVELESLKDAVVGLPGITGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVVCTIHQPSIDIFEAFDELLLLKRGGQVIYAGPLGQNSHKIIEYFQAIHGVPKIKEKYNPATWMLEVSSMAAEAKLEIDFAEHYKTSSLYQQNKNLVKELSTPPQGASDLYFSTRFSQSLLGQFKSCLWKQWITYWRTPDYNLARFFFTLAAAVMLGSIFWKVGTKRENANDLTKVIGAMYAAVLFVGVNNSSSVQPLIAVERSVFYRERAAEMYSALPYALAQVVCEIPYVLIQTTYYTLIIYAMMCFEWTLAKFFWFYFVSFMSFLYFTYYGMMTVALTPNQQVAAVFAGAFYGLFNLFSGFVIPRPRIPKWWIWYYWICPVAWTVYGLIVSQYGDVEDTIKVPGMANDPTIKWYIENHYGYDADFMIPIATVLVGFTLFFAFMFAFGIRTLNFQQR
What is the function of this protein?
May be a general defense protein.
What are the official names of this protein?
ABC transporter G family member 29, ABC transporter ABCG.29, AtABCG29, Pleiotropic drug resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PCFS1_ARATH
Sequence: MASNGSFSAQRNANARTTMKRRSDNRGYGGGIGGYQEETNRYAPPQKRFRSQAQQQFRSGHNPLYHHHGSNNNNVSRVSSQSYNNCGVDVIASNSSFALRNNDSNTNNYQKPFVAGYGNPNPQIVPLPLPYRKLDDNLSLDSLPDWVPNSRTLTPNYPVRSSNFVPNTPVFTNVQNPMNHSNMVSVVSQSMHQPIVLSKELTDLLSLLNNEKEKKTLEASNSDSLPVGLSFDNPSSLNVRHESVIKSLYSDMPRQCSSCGLRFKCQEEHSKHMDWHVRKNRSVKTTTRLGQQPKKSRGWLASASLWLCAATGGETVEVASFGGEMQKKKGKDEEPKQLMVPADEDQKNCALCVEPFEEFFSHEDDDWMYKDAVYLTKNGRIVHVKCMPEPRPAKDLREPSRVMSVTVPSVAKAIAC
What are the official names of this protein?
Polyadenylation and cleavage factor homolog 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y4017_DICDI
Sequence: MKFIYLFKKESTLQNCINELKLKNPGKEIKIHCYFDFRVNGEDKKTTFCLLKLESNIEIPYETFEILNRKQFEKKFNGLENKLEIKNIPSTSSSPSSSQLFLTLPATSQSSQPKSTNSSTESSSIGQFKNQVDENEINLNKNKIDEFQKDVISLQQKVSSLFQQYNKENEKNKTLNQIFDIQNKIQKMQQQIHFIQNNQESFITLFINYKVKIGSAFIIYIFYNVLFFIIVRFNSFFFF
What are the official names of this protein?
Putative uncharacterized transmembrane protein DDB_G0281105.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RNPA_DESRM
Sequence: MKKFVSLKKNSDFRNVYRFGVSAANRYLVLYKFPNKGLGRRFGFSISKKVGKAVCRNRLRRILKELCRFHLDRFSDDCDFVFIVRQTSSDQDFHQMEKHMWHVWGKLNKQEKN
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: LIPB_BACTN
Sequence: MKTVLVDWNLIPYAEAWQRQTEWFDTLVRAKAQGEAYENRIIMCEHPHVYTLGRSGKENNMLLNDDQLKAIQATLFHIDRGGDITYHGPGQLVCYPILNLEEFHLGLKEYVHLLEEAVIRVCASYGIEAGRLEKATGVWLEGSTPRARKICAIGVRSSHYVTMHGLALNVNTDLRYFSYIHPCGFIDKGVTSLRQELKHEVPMDEVKQRLECELGRLLNEKKQQIAQ
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YR336_MIMIV
Sequence: MEILKNHIVSDKLRSSNKCTLLTLNSKFNVIISLEKSPLDKIRELFKSILVDGFTDHNHYKLTAYFAEIVDTDTVINVIIDTVQSKLDSIREALDTNEINLSMYIQIWESYHDFFKNMHLIIKNYQNYLMNKNVTVGKLSLSILSIIEIGMFYNSVIKNNPNDILSSLSKHIYSIDKNNIDQLINYIDSIRSFTLVSGVIDIDKIKLFKIIKNIINSPEIINTLCAYLDTLIRSVSFEKFTKNTEYKTVSIDSIKNQTIRKIYKITIILAAYSDRNVLNLCYSYILTSSCN
What are the official names of this protein?
Uncharacterized protein R336.
Protein: URE1_RHOP2
Sequence: MSTRISRSVYADMFGPTTGDRVRLADTDLIIEVEKDYTTYGEEVKFGGGKVIRDGMGQSQVTNKDGAADTVITNAVVVDHWGIVKADVAIKAGMIHAIGKAGNPDIQPNVDIIIGPGTDIIAGEGKILTAGGFDSHIHFICPQQIEHALMSGVTTMLGGGTGPSHGTFATTCTPGPWHIGRMIQSFDAFPVNLGISGKGNAALPGALIEMVEGGACALKLHEDWGTTPAAIDNCLTVADDHDVQVMIHSDTLNESGFVEDTIKAFKGRTIHAFHTEGAGGGHAPDIIKVAGLANVLPSSTNPTRPFTRNTIDEHLDMLMVCHHLDPSIAEDLAFAESRIRKETIAAEDILHDLGALSMMSSDSQAMGRLGEVIIRTWQTADKMKKQRGSLPQDSSRNDNFRVKRYIAKYTINPSIAHGVSKLIGSVETGKMADLVLWSPAFFGVKPDCIIKAGMIVAAPMGDPNASIPTPQPVHYQPMFGAYGRALTASSVVFTSQAAAAGPLARDLGIAKALYPVSNVRGGISKKSMIHNDATPTIEVDPETYEVRADGELLTCAPAEVLPMAQRYFMY
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEP2_HHV6U
Sequence: MAISTFSIGDLGYLRNFLQNECNWFRICKKTFYREYRSVATSSPTFSLNNKPKKFCMHCEIVIFKRSEEFMFSLAVNGIHFGQFLTGKMKFNKKAVPEGLYYYILELGSITPIDLGFIPRYNSDCVTNMRCVTPEVIYENCSIVCPEEANRLTVKGSGDNKLTPLGGCGAWCLKNGGDLYIYTFALAYDLFLTCYDKSTFPSLAKIIFDMIACESEDCVFCKDHNKHVSQAGQIVGCVSNQETCFCYTSCKKKMANINNPELISLLCDQEINKIDIMYPKIKASLSLDINSYAHGYFGDDPYALKCVNWIPVRISAALSRLIVLSCPVCKRVVMD
What is the function of this protein?
Plays a critical role in cytoplasmic virus egress.  Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid.  Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.
What are the official names of this protein?
Cytoplasmic envelopment protein 2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Note=Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.
Protein: ANGP2_PIG
Sequence: MWQLVFFALSCDLVLAAAYNNFRKSMDSTGKRQYQVQHGPCSYTFLLPETDNCRSPSSSYVSNAVQRDAPLDYDDSVRRLQVLENIMENNTQWLMKLESYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLDMEDKHIVQLQSIKEEKDQLQVLVSKQNSIIEELEKQLVTATVNNSVLQKQQHDLMETVHNLLTMISTSNSAKHSLVAKEEQIIFRDCAEAFKSGLTTSGTYTLTFPNSTEETKAYCDMETGGGGWTVIQRREDGSVDFQRTWKEYKMGFGSPSGEHWLGNEFVSQVTNQKRYVLKIHLRDWEGNEAYSLYEHFYLSSEEFNYRIHLKGLTGTAGKISSISQPGNDFSTKDADNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF
What is the function of this protein?
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling.  Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1.  In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression.  In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.  Involved in the regulation of lymphangiogenesis.
What are the official names of this protein?
Angiopoietin-2, ANG-2.
What are the subcellular locations of this protein?
Secreted.
Protein: VAS1_HUMAN
Sequence: MMAAMATARVRMGPRCAQALWRMPWLPVFLSLAAAAAAAAAEQQVPLVLWSSDRDLWAPAADTHEGHITSDLQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNLENALDLAPSSLVLPAVDWYAVSTLTTYLQEKLGASPLHVDLATLRELKLNASLPALLLIRLPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAVRPSRVARDVAVVAGGLGRQLLQKQPVSPVIHPPVSYNDTAPRILFWAQNFSVAYKDQWEDLTPLTFGVQELNLTGSFWNDSFARLSLTYERLFGTTVTFKFILANRLYPVSARHWFTMERLEVHSNGSVAYFNASQVTGPSIYSFHCEYVSSLSKKGSLLVARTQPSPWQMMLQDFQIQAFNVMGEQFSYASDCASFFSPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTISLTQIV
What is the function of this protein?
Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles (PubMed:33065002).  Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity (PubMed:27231034).  Involved in membrane trafficking and Ca(2+)-dependent membrane fusion (PubMed:27231034).  May play a role in the assembly of the V-type ATPase complex (Probable).  In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).  In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit S1, V-ATPase subunit S1, Protein XAP-3, V-ATPase Ac45 subunit, V-ATPase S1 accessory protein, Vacuolar proton pump subunit S1.
What is the protein family that this protein belongs to?
Belongs to the vacuolar ATPase subunit S1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass type I membrane protein. Note=Not detected in trans-Golgi network.
Protein: IHFB_ECO27
Sequence: MTKSELIERLATQQSHIPAKTVEDAVKDMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: GPDA_SHEAM
Sequence: MKDTADITVLGAGSYGTALAISLASNGHKTLLWGHDPEHIATLSRERCNAAFLPGISFPDCLVMEADLGKALAASRNVLVVVPSHVFGDVLRQAKSLLRADARIVWATKGLEPETGRLLQDVARDALGDAFPLAVLSGPTFAKELAAGLPTAISVAGTDAGFTADLVELLHSPKRLRVYANDDFIGLQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLVELSRLGEALGAQQATFMGMAGLGDLVLTCTDNQSRNRRFGLALGKGCDVNTAQSEIGQVVEGYRNTKEVFTLAKRLGVEMPITEQIYAVLYQGKSPLDAAKELLAREKKSETAAAD
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_NITEU
Sequence: MVTTTLPDFKSHCIQLLDQAARQVLPDEVGVQIELLRPKLADHGDYSSNLAMKLARRLRRNPLELAKALIGALPDSSCVEKADVAGGGFINFFLKKTAKQQFLHAVLQAGDSFGHSRLGAGKTIQIEFVSANPTGPLHVGHGRGAAFGASLANIMTAAGYAVTREFYVNDAGRQMDILTLSTWLRYLDLCGLSFSFPANAYRGQYVADMASEIYQAQGDRYAHRSDATIRQLTEISTSTTIDSEDERLDRLITAAKSILDQDYADLHNFVLTEQLADCRNDLMEFGVEFETWFSEQSLFDSGMVARAVQLLDDKKLLYRQDGALWFRSTDFGDEKDRVVQRENGLYTYFASDIAYHLSKYERGFDYLLNIWGADHHGYIPRVKGAIEALSLDPGRLEIALVQFAVLYRDGKKVSMSTRSGEFVTLRQLRQEVGNDAARFFYVLRKSDQHLDFDLDLAKSQSNDNPVYYVQYAHARICSVLGQWGGAEDILARAETELLTDPAELVLLQKMIDFTDTIEAAAKERAPHLIAFFLRELAGEFHSYYNSTRFLVEDESLKITRLALISAVRQILSKGLTLLGVTAPREM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGSA_SALSV
Sequence: MELTTRTLPTRKHIALVAHDHCKQMLMNWVERHQPLLEKHVLYATGTTGNLIQRATGMDVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVSTADFIIQSPHFNDAVDILIPDYARYLAERLK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: CHH2_PENMO
Sequence: MTAFRLVAVALVVVVACSTTWARSLEGSSSPVASLIRGRSLSKRANFDPSCAGVYNRELLGRLSRLCDDCYNVFREPKVATECRSNCFYNPVFVQCLEYLIPADLHEEYQAHVQTVGK
What is the function of this protein?
Hormone found in the sinus gland of isopods and decapods which controls the blood sugar level.  Has a secretagogue action over the amylase released from the midgut gland.  May act as a stress hormone and may be involved in the control of molting and reproduction (By similarity).
What are the official names of this protein?
Crustacean hyperglycemic hormones 2, Pm-SGP-II.
What is the protein family that this protein belongs to?
Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
What are the subcellular locations of this protein?
Secreted.
Protein: ES8L2_HUMAN
Sequence: MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRGEDS
What is the function of this protein?
Stimulates guanine exchange activity of SOS1.  May play a role in membrane ruffling and remodeling of the actin cytoskeleton.  In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).
What are the official names of this protein?
Epidermal growth factor receptor kinase substrate 8-like protein 2, EPS8-like protein 2, Epidermal growth factor receptor pathway substrate 8-related protein 2, EPS8-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the EPS8 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, stereocilium. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells.
Protein: DCUP_ALIB4
Sequence: MSKIFVDACFRKETPYTPVWMMRQAGRYLPEYMEVRAKAGNFLNLCHNPELAAEVTIQPLDIVGVDAAILFSDILVVPNEMGMKLDFLKGEGPVFDKPIKTEADLDALIGGEEAANKLTYVYETIKILKQRLPQDKALIGFTGAPWTLATYMIEGQGTKTYNLCKKMMYSNPEFLHKILRRVTDVVKFYMEKQIEAGVDVVQIFDSWAAAIEPSKYDEFSWKYMVEIAEYLKEKYPHIPVIMFPKGIAAFIERGLVYGNFDVFGVDWGTPMALAKEKLGEKYVLQGNMEPCRLYSKEATTMCVEGIQNIMGGNGHIFNLGHGILPDVPVENAIHFVKECQRVSKKA
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_CERSK
Sequence: MTEIRLTNTKSRRKEAFEPIDRKNVRLYVCGPTVYDRAHLGNGRPVVVFDVLFRLLRHVYGEGHVTYVRNFTDVDDKINAAALARKDAGDPRSLEALIRERTDETIRWYHEDMDALGALRPTQEPRATEWIGAMIAMIEDLIAKGHAYEREGHVLFRVRSYRDYGALSGRSVDDMIAGARVEVAPFKEDPMDFVLWKPSDDELPGWDSPWGRGRPGWHIECSAMADGLLMKDLPENERSFDIHAGGIDLQFPHHENEIAQSRCAHPEGEFAKVWMHNEMLLVDGKKMSKSLGNFFTVRELIEEYRKQFAVNNIGPAIRLRFLQGHYRAPIDAARHYIEQASVKLGLWWHFISEHLDAPITDKDRRDILATSPVIEALADDLNTPLAVTYIDGLVSRLRGGIQKQGYVDAEMDDLEMVAKRARVAIEFLGFTFDDLEEHHGPVQLKRLKERQLSASADVGVRIGRLLEERAEARKARDFARSDAIRDRLQAAGVLIKDSRDGATWELEPGFDPAKLGEPE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.