PharMolix/UniProtQA huggingface dataset:
Protein: BGLB_PAEPO
Sequence: MSENTFIFPATFMWGTSTSSYQIEGGTDEGGRTPSIWDTFCQIPGKVIGGDCGDVACDHFHHFKEDVQLMKQLGFLHYRFSVAWPRIMPAAGIINEEGLLFYEHLLDEIELAGLIPMLTLYHWDLPQWIEDEGGWTQRETIQHFKTYASVIMDRFGERINWWNTINEPYCASILGYGTGEHAPGHENWREAFTAAHHILMCHGIASNLHKEKGLTGKIGITLNMEHVDAASERPEDVAAAIRRDGFINRWFAEPLFNGKYPEDMVEWYGTYLNGLDFVQPGDMELIQQPGDFLGINYYTRSIIRSTNDASLLQVEQVHMEEPVTDMGWEIHPESFYKLLTRIEKDFSKGLPILITENGAAMRDELVNGQIEDTGRHGYIEEHLKACHRFIEEGGQLKGYFVWSFLDNFEWAWGYSKRFGIVHINYETQERTPKQSALWFKQMMAKNGF
What are the official names of this protein?
Beta-glucosidase B, Amygdalase, Beta-D-glucoside glucohydrolase, Cellobiase, Gentiobiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: ARGO_YERPB
Sequence: MLAVYLHGFILSAAMILPLGPQNVFVMNQGIKRQHHLMSASLCALSDIILICAGIFGGSALLSRSPLLLALVTWGGVAFLMWYGWGALMAAWRGDGVASSATSVTQGRWRILVTLLAVTWLNPHVYLDTFVVLGSLGGQLLPDIRPWFALGAVTASIVWFFALALLAAWLSPWLNRPVAQRIINLFVGGVMGFIAFQLARQGFGL
What is the function of this protein?
Involved in the export of arginine.  Important to control the intracellular level of arginine and the correct balance between arginine and lysine.
What are the official names of this protein?
Arginine exporter protein ArgO.
What is the protein family that this protein belongs to?
Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOZ_XYLFA
Sequence: MARITVEDCLEVVNNRFELVMMASKRARQLANGVPPLIENTNSEDKPTVLALREIAARKIDSKMIDEIEKAERERTEREAMEWAAAEVVADEDMSKSDD
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: LYRA_STAAW
Sequence: MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILVFKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPITHILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYNFLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAIVAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKTGVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESAESVKQAPQSDDLTNDSNEDEIEQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
What are the official names of this protein?
Lysostaphin resistance protein A.
What is the protein family that this protein belongs to?
Belongs to the LyrA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL10_SHIB3
Sequence: MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYMRVVRNTLLRRAVEGTPFECLKDAFVGPTLIAYSMEHPGAAARLFKEFAKANAKFEVKAAAFEGELIPASQIDRLATLPTYEEAIARLMATMKEASAGKLVRTLAAVRDAKEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: VIRB2_BRUSU
Sequence: MKTASPSKKSLSRILPHLLLALIVSIAAIEPNLAHANGGLDKVNTSMQKVLDLLSGVSITIVTIAIIWSGYKMAFRHARFMDVVPVLGGALVVGAAAEIASYLLR
What is the function of this protein?
The VirB system could be required for the establishment of the replication niche in the host.
What are the official names of this protein?
Type IV secretion system protein virB2.
What is the protein family that this protein belongs to?
Belongs to the PtlA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HDOX1_STAAW
Sequence: MKFMAENRLTLTKGTAKDIIERFYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHVRSKNEDESSPIINNKVITYDIGYSYMK
What is the function of this protein?
Allows bacterial pathogens to use the host heme as an iron source.  Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
What are the official names of this protein?
Heme oxygenase (staphylobilin-producing) 1, Heme-degrading monooxygenase 1, Iron-regulated surface determinant 1, Iron-responsive surface determinant 1.
What is the protein family that this protein belongs to?
Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH602_MYCA1
Sequence: MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKSAKEVETKDQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDAERQEAVLEDPFILLVSSKVSTVKDLLPLLEKVIQAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLSLESADISLLGKARKVVVTKDETTIVEGAGDSDAIAGRVAQIRTEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLHAIPALDELKLEGDEATGANIVRVALEAPLKQIAFNGGLEPGVVAEKVRNSPAGTGLNAATGEYEDLLKAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKAAAPAGDPTGGMGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Secreted, capsule. Cell surface. Secreted, cell wall.
Protein: RS24_CANAL
Sequence: MSDAVTIRTRKVISNPLLARRQFVIDVLHPNRANVSKDELREKLAEIYKAEKDAVSVFGFRTQFGGGKSTGFGLIYQSVADAKRFEPAYRLVRYGLAEKVEKASRQQRKQKKNRDKKIFGTQRRAQKRAARRNAD
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
40S ribosomal protein S24.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: KLH23_HUMAN
Sequence: MALKGQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMYIIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCVCVYNV
What are the official names of this protein?
Kelch-like protein 23.
Protein: DBP10_ASPNC
Sequence: MPGRAASPAMSENEFDITNALFQNDSDSDNEAPAKQAKRQPKAAAPQQLDFLNGGGDDDDEDDEAFIAETQASANRKASNLKGRTVKKGGGFQAMGLNANLLKAITRKGFSVPTPIQRKTIPVIMEDQDVVGMARTGSGKTAAFVIPMIQKLKSHSTQVGARGLILSPSRELALQTLKVVKELGKGTDLKAVLLVGGDSLEEQFSMMAGNPDIVIATPGRFLHLKVEMNLDLSSIRYVVFDEADRLFEMGFAAQLTEILHGLPSTRQTLLFSATLPKSLVEFARAGLQEPTLVRLDTESKISPDLQNAFFSVKSGDKEGALMYILHNVIKMPTGPTEAAQRMKEENASGKSSKFSKKRKRSDDKAINFKESPTKHSTIIFAATKHHVDYLYSLLNEAGFATSYAYGSLDQTARKIQVHNFRTGISNILVVTDVAARGIDIPILANVINYDFPSQAKIFVHRVGRTARAGRTGWSYSLVRDSDAPYLLDLQLFLGRRLVLGREHGDQVNFAEDVVVGGFPRDGLSQSCEWVNKVLDDTVDIAAQRSVASKGEKLYLRTRNAASLESAKRSKEVVSSDNWTALHPLFNDETSQLEAEREKMLARIGGYRPNETIFEVNNRRSGKPENEEALTTIKRVRTTLDSKKKRAQEAKSEFVDDDVPTKSGDADADDAEDGAFSDEDEAGEGAADNMSLASESDLEVTFSSYNQPSNKKAKKEASATSFQNPEYFMSYTPNNTNMAEDRAYGVHSGTNANFAQASRDAAMDLLGDEGSRGFGEPRTMMRWDKRHKKYVSRQNDEDGSKGTRLVRGESGAKIAASFRSGRFDAWKKGKRLTRLPRVGEAETPGLGADLNHYRGGRRFKHNKEQAPKRADPLRGDYDKMKKKNEAAKERQLGKFGGAAAGGKSELKGTDDIRLARNLKQKRREKNARPSRKK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase dbp10.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: EFTS_PROM9
Sequence: MGNITAKLVKDLRDKTGAGMMDCKKALNETDGNVDKALEWLRKKGIASAEKKSGRIAAEGSIGSYIHTGSRVGVLLELNCETDFVARGDIFQSLLKDVSMQVAACPNVEYVSIDEIPEDVVEKEKQIEMGRDDLSGKPEQIKEKIVEGRIAKRLNELVLLSQPYIKDSSLTVEDLVKQAAAKIGENIKVRRFTRYTLGEGIEKNQMDFAEEVASMKSN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURP_PYRAB
Sequence: MVKIVVRIATYASHSALQILKGAKDEGFETIAFGSERVKPLYTKYFPVADYFLVGKYPEDELLELNAVVIPTGSFVAHLGVELVERMKVPYFGNKRVLKWESDRNLERKWLEKAKLKLPRVYDDPDDIDRPVIVKPHGAKGGRGYFIAKDPQDFWTKVEKFLGIKDKEDLKNVQIQEYVIGVPVYPHYFYSKLTRELELMSIDRRYESNVDAIGRIPSKDQLELELDITYTVIGNIPLVLRESLLMDVIEAGERTVKAAEELMGGLWGPFCLEGVFTPDLDFVVFEISARIVAGTNPFINGSPYTWLKYDEPMSTGRRIAREIRLAIEEDKLDEVVS
What is the function of this protein?
Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
What are the official names of this protein?
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: AMP_STEME
Sequence: MGKLPLLLLLLSVFLTSTLALRLSNEDRQQELGQCLHRCDIRRYSPDMQRACRHKCHMDFGGRKSDEFVVVDYHYEEPELFSLSPYQMCKFHCRADDSGSFGRMLECEKKCAEEYGNENSRNVDERSPSDSRKRFEECRRKCQKTHPDKQLECIRKCQKAQGERKGDYTFEVCERRCQDTRHGSKLACIDRCVKEGRDNEGRPVSPKCQKKCEGEGYICQRMCMKGSDDDTQDRQVSLKCQKMCEGKGYDCQKRCMRMDQSDDNDQDTQVSKMCQKMCQGKSYECQRKCMKECDDDTQGRQVSLKCQRMCRGEGYDCQKKCMRIDQSDDNEDPQISKMCQKMCQGKGYVCESMCMKGGHDDTQCQKMCQGKGDDCQKMCMGMDQSDKNEDPQVSQMCQQICQGEGRGCLQRCKRAEKVDDANTEMNVDPDVRAYCKHQCMSTRGDQARKICESVCMRQDGKIMLLSTISEVVARLLDD
What is the function of this protein?
The mature peptide has antifungal activity against germinated and ungerminated spores of A. alternata (IC(50)=7. 4 uM and IC(50)=12. 5 uM, respectively), A. niger (IC(50)=2. 8 uM and IC(50)=4. 0 uM, respectively), B. cinerea (IC(50)=9. 3 uM and IC(50)=16. 2 uM, respectively), F. oxysporum (IC(50)=8. 0 uM and IC(50)=5. 4 uM, respectively) and F. solani (IC(50)=8. 0 uM and IC(50)=7. 2 uM, respectively).  Has no activity against B. sorokiniana, P. infestans and P. ultimum.  Has no antibacterial activity towards C. michiganensis, E. carotovora, E. coli and P. syringae at concentrations up to 40 uM.
What are the official names of this protein?
Antimicrobial peptide X precursor.
What are the subcellular locations of this protein?
Secreted.
Protein: SMG_ENT38
Sequence: MFDVLMYLFETYIHNEAEMRVDQDRLTRDLTDAGFEREDIYNALLWLEKLADYQEGLVEPMQLASDPLSVRIYTAEECERLDASCRGFVLFLEQIQVLNLETREMVIERVMALDTAEFELEDLKWVILMVLFNIPGCENAYQQMEELLFEVNEGMLH
What are the official names of this protein?
Protein Smg.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: AN30A_HUMAN
Sequence: MEEISAAAVKVVPGPERPSPFSQLVYTSNDSYIVHSGDLRKIHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNHQNTNPEGTSAGTPDEAAPLAERTPDTAESLVEKTPDEAAPLVERTPDTAESLVEKTPDEAASLVEGTSDKIQCLEKATSGKFEQSAEETPREITSPAKETSEKFTWPAKGRPRKIAWEKKEDTPREIMSPAKETSEKFTWAAKGRPRKIAWEKKETPVKTGCVARVTSNKTKVLEKGRSKMIACPTKESSTKASANDQRFPSESKQEEDEEYSCDSRSLFESSAKIQVCIPESIYQKVMEINREVEEPPKKPSAFKPAIEMQNSVPNKAFELKNEQTLRADPMFPPESKQKDYEENSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPNKDGLLKATCGMKVSIPTKALELKDMQTFKAEPPGKPSAFEPATEMQKSVPNKALELKNEQTLRADEILPSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKINGKLEGSPVKDGLLKANCGMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADEILPSESKQKDYEESSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPDNDGFLKAPCRMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADQMFPSESKQKKVEENSWDSESLRETVSQKDVCVPKATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQLENQKVKWEQELCSVRLTLNQEEEKRRNADILNEKIREELGRIEEQHRKELEVKQQLEQALRIQDIELKSVESNLNQVSHTHENENYLLHENCMLKKEIAMLKLEIATLKHQYQEKENKYFEDIKILKEKNAELQMTLKLKEESLTKRASQYSGQLKVLIAENTMLTSKLKEKQDKEILEAEIESHHPRLASAVQDHDQIVTSRKSQEPAFHIAGDACLQRKMNVDVSSTIYNNEVLHQPLSEAQRKSKSLKINLNYAGDALRENTLVSEHAQRDQRETQCQMKEAEHMYQNEQDNVNKHTEQQESLDQKLFQLQSKNMWLQQQLVHAHKKADNKSKITIDIHFLERKMQHHLLKEKNEEIFNYNNHLKNRIYQYEKEKAETENS
What are the official names of this protein?
Ankyrin repeat domain-containing protein 30A, Serologically defined breast cancer antigen NY-BR-1.
Protein: TNFA_TUPTA
Sequence: MSTENMILDVHLAEEALPKKAGGPQSSRRCMLLSLLSFLLVAGATTLFCLLHFGVIGPQKEELPDGLRLVNPLTQTLTLRSSGIPSDKPAAHVIANPQNKGELQWLNRRANTLLTNGMQLVDNQLVVPSDGLYLIYSQVLFTGLGCPSTPVLFTHTVSCVAVSYNNKVNLLSAIKSPCQKETAEGAEAKPWYEPIYQGGVFQLQKGDRLSAEVNLPRYLDFAESGQVYFGVIAL
What is the function of this protein?
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
What are the official names of this protein?
Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted. SUBCELLULAR LOCATION: [C-domain 1]: Secreted. SUBCELLULAR LOCATION: [C-domain 2]: Secreted.
Protein: TRMB_PAEAT
Sequence: MSETPDSPRPVTPGSQASFGTYGGRPVSFVRRGTRLQGRRQAAWEEHAERWAIQVPRHVANTSVHPDYTFDAEAVFGRKAPLIVEIGSGLGDAVVHAAEQNPDKDFLAVEVYTPGLANTIIKINSRGLTNVRVVEANAPEVLESMLPEGSVSELWVFFPDPWHKARHHKRRLIQPAFASVAAKALVKGGYWRIATDWSNYAVHVREVLTGSTEFENMHEGERSGEESPLTQVWQSGVESVVGGAPVREGRAPVSTEHTGPNEGVDEEGGWAPRFDGRIRTSFENKAHEAGRMIFDLTYRKR
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: IL4_AILME
Sequence: MGLTSQLIPTLVCLLALTSTFVHGHNFNITIKEIIKTLNILTARNDTCMELTVTNIFAAPKNTTDTETFCRATTVLQQLSTHSCSNKLLGGLHRNLKTMANMTCSVNEVKKSTLRDFLERLKAIVQRKYYRH
What is the function of this protein?
Participates in at least several B-cell activation processes as well as of other cell types.  It is a costimulator of DNA-synthesis.  It induces the expression of class II MHC molecules on resting B-cells.  It enhances both secretion and cell surface expression of IgE and IgG1.  It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.  Positively regulates IL31RA expression in macrophages.  Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
What are the official names of this protein?
Interleukin-4, IL-4, B-cell stimulatory factor 1, BSF-1, Lymphocyte stimulatory factor 1.
What is the protein family that this protein belongs to?
Belongs to the IL-4/IL-13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRM3_HCMVM
Sequence: MLRGDSAAKIQERYAELQKRKSHPTSCISTAFTNVAALCRKRYQMMHPELGLAHSCNEAFLPLMAFCGRHRDYNSPEESQRELLFHERLKSALDELTFRPCSEEQRASYQKLDALTELYRDPQFQQINNFMTDFKKWLDGGFSTAVEGDAKAIRLEPFQKNLLIHVIFFIAVTKIPVLANRVLQYLIHAFQIDFLSQTSIDIFKQKATVFLVPRRHGKTWFIIPIISFLLKHMIGISIGYVAHQKHVSQFVLKEVEFRCRHTFARDYVVENKDNVISIDHRGAKSTALFASCYNTNSIRGQNFHLLLVDEAHFIKKEAFNTILGFLAQNTTKIIFISSTNTTSDATCFLTRLNNAPFDMLNVVSYVCEEHLHSFTEKGDATACPCYRLHKPTFISLNSQVRKTANMFMPGAFMDEIIGGTNKISQNTVLITDQSREEFDILRYSTLNTNAYDYFGKTLYVYLDPAFTTNRKASGTGVAAVGAYRHQFLIYGLEHFFLRDLSESSEVAIAECAAHMIISVLSLHPYLDELRIAVEGNTNQAAAVRIACLIRQSVQSSTLIRVLFYHTPDQNHIEQPFYLMGRDKALAVEQFISRFNSGYIKASQELVSYTIKLSHDPIEYLLEQIQNLHRVTLAEGTTARYSAKRQNRISDDLIIAVIMATYLCDDIHAIRFRVS
What is the function of this protein?
Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging.  Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm.  Once the complex reaches the host nucleus, it interacts with the capsid portal vertex.  This portal forms a ring in which genomic DNA is translocated into the capsid.  TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
What are the official names of this protein?
Tripartite terminase subunit 3, Terminase large subunit.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae TRM3 protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2.
Protein: KAZD1_HUMAN
Sequence: MLPPPRPAAALALPVLLLLLVVLTPPPTGARPSPGPDYLRRGWMRLLAEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSAHFYGHCGEQLECRLDTGGDLSRGEVPEPLCACRSQSPLCGSDGHTYSQICRLQEAARARPDANLTVAHPGPCESGPQIVSHPYDTWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQLPGDDPHISVQFRGGPQRFEVTGWLQIQAVRPSDEGTYRCLGRNALGQVEAPASLTVLTPDQLNSTGIPQLRSLNLVPEEEAESEENDDYY
What is the function of this protein?
Involved in the proliferation of osteoblasts during bone formation and bone regeneration.  Promotes matrix assembly (By similarity).
What are the official names of this protein?
Kazal-type serine protease inhibitor domain-containing protein 1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: NUOD_METS4
Sequence: MTEHSIRNFSINFGPQHPAAHGVLRLVLELDGEIVERVDPHIGLLHRGTEKLIEVKTYLQATPYFDRLDYVAPMNQEHAFCLAVEKLLGIEVPRRAKLIRTLFCEIGRLLSHLLNVTTQAMDVGALTPPLWGFEEREKLMIFYERASGARLHANYFRPGGVHQDLPPGLIDDIEAFCDPFLQVVDDLDALVIGNRIFKQRNVDIGIVTVDAAMAWGFSGVMLRGSGIPWDLRRAQPYEAYEEMEFDVPVGKNGDTYDRQVIRMEEMRQSVRIMKQCLAKLRAPDGQGPVTTQDGKVAPPSRREMKRSMEALIHHFKLYTEGFHVPAGEVYAAVEAPKGEFGVYLVADGTNKPYRCKIRAPGFAHLQAMDWMCRGHMLADVSCILGTLDIVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LPXK_CERS1
Sequence: MRPPAFWFTPPDSPALAARLLAPLGQAYAAATARRLRAPGHRAGVPVICIGNLNAGGTGKTPTAIALMQRLAARGIEAHVVSRGYGGRLEGPVEVDARRHRAADVGDEPLLLAAFGRAWVARDRAAGVRAAEAAGAQAILLDDGFQNPSVVKDLSLIVVDAAVGFGNGRCLPAGPLREPVEAGLARADLLLSIGGPEAQRRFATDWPALPVPRLTGRLATLQMGMDWQGARVLAFAGIGRPEKFFASLRAEGAELLRAEALDDHQPLGEALMKRLEIEAMALGAQLVTTEKDAVRLPPSFRQKVLTLPVRLEFDDGAALDEALDRLGLAARS
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: YAAI_ECOLU
Sequence: MKSVFTLSASLAISLMLCCTAQANDHKILGVIAMPRNETNDLALKLPVCRIVKRIQLSADHGDLQLSGASVYFKAARSASQSLNIPSEIKEGQTTDWININSDNDNKRCVSKITFSGHTVNSSDMATLKIIGDD
What are the official names of this protein?
UPF0412 protein YaaI.
What is the protein family that this protein belongs to?
Belongs to the UPF0412 family.
Protein: LPXA_CAMLR
Sequence: MSKIHPSAVVEDGAIIGDEVIIEAYSFVGANAKIGNNVVIKQGARILPNVKIGDDSKIFSYAIVGDIPQDISYKDEINSGVIIGKNATIREFVTINSGTAKGDGYTRIGDNAFIMAYSHIAHDCILGNNIILANNATLAGHVELGDYTVVGGLTPIHQFVKVGEGCMIAGASALSQDIVPFCLAEGNRASIRSLNLVGLRRRFDKEEIDILSKTFKILFKQGNLKDNALNLLESTSSENVKKMCNFILETKRGIPIYKEKNHG
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_CORGB
Sequence: MSSTTLTDDQIRDNERTEVLAKATAAKNIVPDIAVLGTGPKNAILRAAADELVARSAEIIEANASDIEAGRANGMEESMIDRLALDESRIEGIAGGLRQVAGLTDPVGEVLRGHVMENGIQMKQVRVPLGVMGMVYEARPNVTVDAFGLALKSGNVALLRGSSTAVHSNTKLVEILQDVLERFELPRETVQLLPCQTRGSVQDLITARGLVDVVIPRGGAGLINAVVTGATVPTIETGTGNCHFYIDAEAKLDQAIAMVINGKTRRCSVCNATETALLDAALSDSDKLAVVQALQEAGVTIHGRVAELEAFGATDVVEATETDWDSEYLSFDIAVAVVDGVDGALAHIAKYSTKHTEAIATQNIETAQRFADRVDAAAVMINASTAYTDGEQYGMGAEIGISTQKLHARGPMALPELTSTKWILQGTGQIRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.