PharMolix/UniProtQA huggingface dataset:
Protein: MOT1_NEUCR
Sequence: MFFTKPRLHRIITHNLHHLLSPHLLLSEISGSLGDLGTLLPLLLALSLQGSIDLPSTLLFSGLFNILTGLVFGVPLPVQPMKAIAAASLQENADLETTVAAGAWVGFAVLLLGGTGGLKRVMRWVPGAVVRGVQVGAGMSLVVAAGGGMVRPLGWLWTPEENENGHGGLGEWLDSRALAVLAFGGLVVGLGQQQQQQQQSGEKPQERRKKRSKMPVQVPYALVLFLVGIMFAVVRVSLSKDSPQSPPPPPHDQPTNSAPPWTWIWNPLNHIHPKVFRSLLNPQALSMAIAQLPLTTLNSIIAASALASDLFPPDSYPQLYADDESSDSPLSPSPSASSSSLSSAPPQTPSAETPKPLSSPTSAEEGPVPLTPLSLSISAMNLLSAPFGCMPLCHGSGGLAAQHRFGARSGTSIILLGLTKFLLGLFFPGPGLLGLLGKFPKAFLGVMVLGAGVELARVGVRNVEGEEQDRMVMLMTAGTILAFKNDGVGFLAGMGCYGGFRVAAWLGGGTEKGRGGEQGLLGEEEEEEEQGRVDEESPLLR
What is the function of this protein?
Exports stored molybdate from the vacuole into the cytosol, making it available for molybdate cofactor (Moco) biosynthesis (PubMed:36240974).  Plays a role in molybdate homeostasis as high cytosolic levels of molybdate are toxic to cells (PubMed:36240974).  Not required for molybdate import into cells (PubMed:36240974).
What are the official names of this protein?
Molybdate transporter 1, NcMOT-1, Vacuolar molybdate exporter 1.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Protein: TGT_STAAT
Sequence: MPAVTYEHIKTCKQSGARLGIVHTPHGSFETPMFMPVGTKATVKTMSPEELRQIEAKIILGNTYHLWLQPGNDIIKHAGGLHKFMNWDGPILTDSGGFQVFSLSNLRKITEEGVEFRHHTNGSKLFLSPEKSMQIQNDLGSDIMMAFDECPPMPAEYDYVKKSIERTTRWAKRCLDAHQRPEDQALFGIIQGGEYEDLREQSAKDLVELDFPGYAIGGLSVGEPKPVMYKMVEHTEQFMPKDKPRYLMGVGSPDALIECSIRGMDMFDCVLPTRIARNGTCMTSQGRLVIKNAKFADDLRPLDENCDCYTCQNYSRAYIRHLIKAEETFGIRLTTIHNLHFLLKLMEDIRQAIREDRLLDFKEEFFEQYGLNVENPKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: UREE_CHESB
Sequence: MIRATSVTAKFDRAFDTITLDETARHRRRMMMRSDNGIEFLLDLPEARLLNHGDGLLLEDGRVIEVRALPEPLYEVRGRDSRHLLALAWQIGNRHLPAEIAEDRILIRRDHVIRDMLEGLGAMVTDITAPFSPEGGAYQAHSHDGHSHHQGHTHDHHD
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_LACLS
Sequence: MAVTAAQVKELREKTGAGIMDAKRALVETDGNMEAAAELLREKGIAKAAKKADRVAAEGLTGIAVNGNVAALVELNSETDFVAKNDQFVALVKETAELLAASKPANNEEALAIKTASGVTLEQELVQATATIGEKITFRRFVVIEKTDAQHFGAYQHNGGKIGVISVIEGADETLAKQVSMHIAAMNPTVLSADELDSEFVKAELAQMNHKIDEDNASRVLVNKPELPHHEYGSKSQLTEEVLAAAKASFEEELKAEGKPEKIWDKILPGKMAKFIVDNTKVDQQFALLAQLYIMDDSKTVEAFLESKGAKAIAFTRFEVGEGIEKAETDFAAEVEAAKAGL
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHBE_ECOLI
Sequence: MKQQAGIGILLALTTAICWGALPIAMKQVLEVMEPPTIVFYRFLMASIGLGAILAVKKRLPPLRVFRKPRWLILLAVATAGLFGNFILFSSSLQYLSPTASQVIGQLSPVGMMVASVFILKEKMRSTQVVGALMLLSGLVMFFNTSLVEIFTKLTDYTWGVIFGVGAATVWVSYGVAQKVLLRRLASPQILFLLYTLCTIALFPLAKPGVIAQLSHWQLACLIFCGLNTLVGYGALAEAMARWQAAQVSAIITLTPLFTLFFSDLLSLAWPDFFARPMLNLLGYLGAFVVVAGAMYSAIGHRIWGGLRKHTTVVSQPRAGE
What are the official names of this protein?
Uncharacterized inner membrane transporter YhbE.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DUS_STAAM
Sequence: MKENFWSELPRPFFILAPMEDVTDIVFRHVVSEAARPDVFFTEFTNTESFCHPEGIHSVRGRLTFSEDEHPMVAHIWGDKPEQFRETSIQLAKMGFKGIDLNMGCPVANVAKKGKGSGLILRPDVAAEIIQATKAGGLPVSVKTRLGYYEIDEWKDWLKHVFEQDIANLSIHLRTRKEMSKVDAHWELIEAIKNLRDEIAPNTLLTINGDIPDRKTGLELAEKYGIDGVMIGRGIFHNPFAFEKEPREHTSKELLDLLRLHLSLFNKYEKDEIRQFKSLRRFFKIYVRGIRGASELRHQLMNTQSIAEARALLDEFEAQMDEDVKIEL
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
What are the official names of this protein?
Probable tRNA-dihydrouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the Dus family.
Protein: ILVD_YERPG
Sequence: MPKYRSHTTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIVASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLIDAMIQGANPNVSDEESAQIERSACPTCGSCSGMFTANSMNCLNEALGLALPGNGSLLATHADRKQLFLDAGKHIVALTKRYYEQDDVSALPRNIANKAAFENAMILDIAMGGSTNTVLHLLAAAQEGEIDFSMTDIDHLSRKVPHLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVSNVLGLNLTQTLEAYDVMLTQDEGVKQMYAAGPAGIRTTKAFSQDCRYPSLDTDREEGCIRTREHAYSQDGGLAVLYGNIAADGCIVKTAGVDKDSLTFRGPAKVFESQDEAVEAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHVSPEAASGGLIGLVQDGDFINIDIPNRGIVLDVSEAELAARRETEEAHGDAAWSPKGRERQVSYALRAYAMLATSADKGAVRDKSKLGG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: DNAA_RHOP5
Sequence: MTNIEQERWSRVKGRLRTTVGEDVYSSWFARMDLESVQQESVHLSVPTRFLKSWIQTHYSERVLSCWQAEMPEVHRIDLTVRTAMRCAAPAKEQAAPIEPRREDNRAAAHDLRVSATAPVSANHEALGGSPLDPRLTFSSFVVGRSNTLAHAAAKQVAEGRRGDPVMFNPLYIHSGVGLGKTHLLQAVTWAGNSGLERKVLYLTAEKFMYGFVAALKSQTALAFKEALRGIDVLVIDDLQFLQGKTTQAEFCHTLNALIDAGRQVVIAADRPPSDLESLDERVRSRLAGGLVVEMASLGEELRLGILKSRVTAARAHHASFEVPLPVLEYLAHSITHNGRDLEGAINRLLAHSKLNAQPVTLEMAEREVRDLIRPQEPKRIKIEDIQRVVARQYNVSRSDLLSSRRTANVVRPRQVAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRKIEGLVSKDAALSDEVESLKRQLQE
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC014_BOVIN
Sequence: MTSLFTQEIRLSKRHEKIVSQRLMLLQQMENKPEDQNKGRASQTQAAKAALQRNVSLLKDIEAAEKSLQTRMYPALPPEVAALETLYWASVEEYIPKWEQFLLGRAPYPACSENGNEAEDTIPKRAQQ
What are the official names of this protein?
Uncharacterized protein C3orf14 homolog.
Protein: Y1063_HAEIN
Sequence: MERKEYKVFKSGLNFLEGIANWIGIKNPQLTQTEDLFSNESDKNDFGLQKRIDEKYRKDDDPAIDIRPKH
What are the official names of this protein?
Uncharacterized protein HI_1063.
Protein: ATPG_BREBN
Sequence: MAKGIREIRRSIKSKKDMRQITKAMKMVAAAKLRRNQDKAEAARPYADKIQEVIASIASGTSGSKHPMLQNRPVKKTGYIVITSDRGLAGGYNANILRKVVNTINEKHKSKDEYGIFVIGRKGRDFFSKRNYPLLDEVTGLPTSPAFADIKKIAGAAVQMFENEQIDELYLCYNKFQSAISQIPTVKQLLPLEAPESNNARAINYEYEPSSEEVLADLLPKYAETLVYSALLEAKASEEGSRMTAMGNATDNATDMINRLTLSYNRARQAAITQEISEIVAGANAQA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: WECF_SHIDS
Sequence: MTVLIHVLGSDIPHHNRTVLRFFNDALAATSEHAREFMVVGKDDGLSDSCPALSVQFFPGKKSLAEAVIAKAKANRQQRFFFHGQFNPKLWLALLSGGIKSRQFFWHIWGADLYELSSGLIYKLFYPLRRLAQKRVGCVFATRGDLSFFAKTHPKVRGELLYFPTRMDPSLNTLANDRQREGKMTILVGNSGDRSNEHVAALRAVHQQFGDTVKVVVPMGYPPNNEAYIEEVRQAGLELFSEENLQVLSEKLEFDAYLALLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNRENPFWQDMTEQHLPVLFTTDDLNEDIVREAQRQLASVDKNTIAFFSPNYLQGWQRALAIAAGEVA
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
What are the official names of this protein?
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase, 4-alpha-L-fucosyltransferase, TDP-Fuc4NAc:lipid II Fuc4NAc transferase, Fuc4NAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 56 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TILS_FRATW
Sequence: MSISKSLVLNEIKKFSPSHIIIGYSGGVDSSVLLNISKELDIPLIAIYINHNLHRDSLKWQIHCQQTCQKYNLQFISHSLDKVPKGESFEAWASKQRMAFFQKIMQQYSKPLLLLGHHQDDQAETFLIQAIRGSGLAGLAGIPHYKELHHGGVLRPLLKYSKIEIEGFAKLNNISYIYDDSNEDIKYRRNLIRNQIIPILQQVNPNISQTLSRSANICAESNNILQKLLTERLQSISQDTNLIISELIKLDDDIQKNLLHLWFKQNTQQSLKSKQIKELHLAVNNPSTGWQIDISNYYQIHIQYNQLIIKYPTTINDISKEDIISWLSKNLNEEIDLTKIVIRDRKPDDKCKYRGRNKPNKLKILFQELQIPTTERSKAKIILKDQQIIAVYPFFICG
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCBS_OENBE
Sequence: MSIVELFHYSLFLGLFVAFTYNKKEPPAFGAALAFWCILLSFLGLLFCHISNNNSNYNVLTANAPFFYQISGTWSNHEGSILLWCWILSFYGFLLCYRGRPQSHNVSKRGGYRETFFYFFVLNFVKNFILSLLCYEQKTLAVPQLYTPFVLRTLVDSELCSRRNRTFDGPALFYAPLYPERKMSFAFLGARLPVVRGEGKRTYLLLHLARDDKERASSIDEQRIDGALGIALFFSFFLLASSDFFVRNFFVCTEPLAELNPVLQDPILAIHPPCIYAGDVASAMGFCLCRSKMMNGIVALHSPPMWKDAAEKNGRLLCSAGCVGFRITSELFTLKFKDVGAKCYPALLLRSNRSPLMLLRRRFFAFSLLWTGALVDTGREQAKRVVRNGKKDTATSPLSWTAGANTVVSDQDQEPIRIWILTCWCFLNVGILLGSWWAYHELGWGGWWFWDPVENASFMPWVLATACIHSVILPLLHSCTLLINIVTFLCCVLGTFSIRSGLLASVHSFATDDTRGIFLWRFFLLMTGISMILFSQMKQQASVRRTYQKEMVVARSTLVHLRHSARAQPRPQLLWKN
What is the function of this protein?
Could be involved in assembly and maturation of cytochromes c.  May play a role in guidance of apocytochromes and heme groups for the covalent linkage introduced by the cytochrome-c-heme lyase.
What are the official names of this protein?
Probable cytochrome c biosynthesis protein.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PCP_YERPB
Sequence: MRRVLITGFEPFGGERINPSWEVVKQMNDLMMGGVRIVARQLPCAFGEALTALNTAIDDVQPVLVLAIGQAGGRADITIERVAINVDDARIPDNLGNQPVDQPIIQEGPAAYFTRLPIKAMVQGIREAGIPASVSQTAGTYVCNHVMYGLLHRLNQFNNEVKGGFIHIPYLPEQAVDHPGAPSMSAQSVLVALELAISIALQIEHDLHITGGAVH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTZI_BACSU
Sequence: MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHTIDPPQENHSDSHNQ
What are the official names of this protein?
Uncharacterized membrane protein YtzI.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RF3_SODGM
Sequence: MKNELYADEIAARRTFAIISHPDAGKTTITEKVLLFGQAIQTAGTVKGRGSNQHAKSDWMEMEKQRGISITTSVMQFPYRQALVNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDAAKGVEDRTRKLMEVTRLRDTPILTFMNKVDRDIRDPMELLDEVESELRIACAPITWPIGCGKLFKGIYHLAKDETYLYQSGQGHTIQAVRVVKGLDNPELDQAVGEDLAAQLREELELVQGASHPFDEQAFLAGELTPIFFGTALGNFGIDHMLDGLVAWAPPPMPRQTDVRVVSAREEKFTGFVFKIQANMDPRHRDRVAFLRVVSGRYEKSMKLRQVRTGKDVVIADALTFMAGDRSHIEEAYAGDIIGLHNHGTIQIGDTFTQGEELKFTGIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLANNDLIVGAVGVLQFDVVVARLKSEYNVEALYEPVNVSTARWVECGDAKKLEEFKRKNELNLVLDGGDNLSYIAPSMVNLNLTRERYPDIQFHKTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_NITSB
Sequence: MAIKALRGMKDILPPLSEKYLNFLQTASHYAHNYGFSYIETPLLEETALFKRSVGESSDIVGKEMYQFIDKGGNDIVLRPEGTAGVVRSFIEHKLDRQGGTHRFFYYGSMFRYERPQKGRFRQFHQFGVESFGEPSVYEDAAIITLAKAILDHFEIDYTLKINSLGCPVCLKPYREELIKFLEDQEHICDDCKRRRKLNPIRVLDCKNEQCQQIYENAPKLINNLCEECNQEFQTLKNLLDNEGIIYEVDENLVRGLDYYTRTAFEFVSNALGAQNAVAGGGRYDNLVEMLGGKPTPAVGFAIGIERILDLIKDKPVQREGYFIGVMLPEALNIAFDIATKLRQSNRVIMEYKPKSLKALLKGADRNNAKYALIIGEDEYNEGLVWIKDLERKEEKRVDIQNFMER
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_CHLTR
Sequence: MKQQKQRIRIRLKGFDQGQLDQSTANIVETAKRTGARVVGPIPLPTKREVYTVLRSPHVDKKSREQFEIRTHKRLIDILDPTGKTIDALKMLSLPAGVDIKIKAA
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: CH105_RHILO
Sequence: MAKSKFRPLHDRVVVRRVESESKTAGGIIIPDTAKEKPQEGEIIAVGSGARDEAGKLVPLDVKAGDRILFGKWSGTEVKLNGEDLLIMKESDIMGIIG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES 5, 10 kDa chaperonin 5, Chaperonin-10 5, Cpn10 5.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZPBP1_PIG
Sequence: MEASAPDRARRGWRRARAAASPLSRAAVVLLLSALVLRAPPSVGYLDRLPRSFHLTQESAKIVGSPNFPVKVYVMLHQKSPHVLCVTQRLRNFELVDPSFQWHGPKGKIVSENSTAQVTSTGSLVFQNFEESMSGVYTCFLEYKPTVEEVVKNLQLKYIIYAYREPRYYYQFTARYHAAPCNSIYNISFEKKLLQILSKLVLDLSCEVSLLKSECHRVKMQRAGLQNELFFTFSVSSLDTEKGPKPCAGHSCESSKRLSKAKNLIERFFNQQVEVLGRRAEPLPEIYYIEGTLQMVWINRCFPGYGMNILKHPKCPECCVICSPGTYNSRDGIHCLQCNSSLVFGAKACL
What is the function of this protein?
Plays a role in acrosome compaction and sperm morphogenesis.  Is implicated in sperm-oocyte interaction during fertilization.
What are the official names of this protein?
Zona pellucida-binding protein 1, Inner acrosomal membrane IAM38, Sp38.
What is the protein family that this protein belongs to?
Belongs to the zona pellucida-binding protein Sp38 family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Peripheral membrane protein. Note=First localized in acrosome granule, later migrates to the inner and outer acrosomal membrane. Released after the acrosomal reaction.
Protein: VL1_HPV51
Sequence: MALWRTNDSKVYLPPAPVSRIVNTEEYITRTGIYYYAGSSRLITLGHPYFPIPKTSTRAAIPKVSAFQYRVFRVQLPDPNKFGLPDPNLYNPDTDRLVWGCVGVEVGRGQPLGVGLSGHPLFNKYDDTENSRIANGNAQQDVRDNTSVDNKQTQLCIIGCAPPIGEHWGIGTTCKNTPVPPGDCPPLELVSSVIQDGDMIDTGFGAMDFAALQATKSDVPLDISQSVCKYPDYLKMSADTYGNSMFFHLRREQIFARHYYNKLVGVGEDIPNDYYIKGSGNGRDPIESYIYSATPSGSMITSDSQIFNKPYWLHRAQGHNNGICWNNQLFITCVDTTRSTNLTISTATAAVSPTFTPSNFKQYIRHGEEYELQFIFQLCKITLTTEVMAYLHTMDPTILEQWNFGLTLPPSASLEDAYRFVRNAATSCQKDTPPQAKPDPLAKYKFWDVDLKERFSLDLDQFALGRKFLLQVGVQRKPRPGLKRPASSASSSSSSSAKRKRVKK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: MIAB_STAAM
Sequence: MNEEQRKASSVDVLAERDKKAEKDYSKYFEHVYQPPNLKEAKKRGKQEVRYNRDFQIDEKYRGMGNERTFLIKTYGCQMNAHDTEVIAGILEALGYQATTDINTADVILINTCAIRENAENKVFSEIGNLKHLKKERPDILIGVCGCMSQEESVVNKILKSYQNVDMIFGTHNIHHLPEILEEAYLSKAMVVEVWSKEGDVIENLPKVREGNIKAWVNIMYGCDKFCTYCIVPFTRGKERSRRPEDIIDEVRELAREGYKEITLLGQNVNSYGKDLQDIEYDLGDLLQAISKIAIPRVRFTTSHPWDFTDHMIDVISEGGNIVPHIHLPVQSGNNAVLKIMGRKYTRESYLDLVKRIKDRIPNVALTTDIIVGYPNESEEQFEETLTLYDEVGFEHAYTYLYSQRDGTPAAKMKDNVPLNVKKERLQRLNKKVGHYSQIAMSKYEGQTVTVLCEGSSKKDDQVLAGYTDKNKLVNFKAPKEMIGKLVEVRIDEAKQYSLNGSFVKEVEPEMVIQ
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PER_CYNCS
Sequence: VVSCADITALAARQGLFTSDQDLYTDSRMGQLNVLTGTQGEIR
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
Protein: IFNG_BUBCA
Sequence: MKYTSYFLALLLCVLLGFSGSYGQGQFFREIENLKEYFNASNPDVAKGGPLFSEILKNWKDESDKKIIQSQIVSFYFKLFENLKDNQIIQRSMDIIKQNMFQKFLNGSSEKLEDFKKLIQIPVDDLQTQRKAINELIKVMNDLSPKSNLRKRKRSQNLFRGRRASM
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: AAEB_SALPK
Sequence: MGIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIAALIIIISMIRAPLLMILVCCVWVGFCTWISSLVRIENSYAWGLSGYTALIIVITIQTEPLLTPQFALERCSEIVIGIGCAILADLLFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKALNTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGERETPVTLYSWVGAATRYLLLKRGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGNGEMVMIAVVTSLAMRLPNPRMVCIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVISAGSDDKRRRYFGQLLDELDIYQEKLRIWEAPPQVTEPVKRLTGMLHKYQNALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.