PharMolix/UniProtQA huggingface dataset:
Protein: MSRB1_ORYSJ
Sequence: MAMRQYAAATAASSSFRARPRARPSCLPAAALPLAPCCGVAWSRASYRRASVRAMGAASSSSSSSSSSPSPQGQAQAQAQGKPNYSTSLTDEEWRKRLTKDQYYITRQKGTERAFTGEYWNTKTPGIYHCVCCDTPLFESSTKFDSGTGWPSYYQPIGDNVKCKLDMSIIFMPRTEVLCAVCDAHLGHVFDDGPRPTGKRYCINSASLKLKKTQ
What is the function of this protein?
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins.  Involved in abiotic stress response.  Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation.  MSRB family specifically reduces the MetSO R-enantiomer.
What are the official names of this protein?
Peptide methionine sulfoxide reductase B1, chloroplastic, OsMSRB1, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL30_ROSDO
Sequence: MAKTIVIKQIGSPIRRPAKQRATLIGLGLNKMHKTRELEDTPSVRGMINSIPHMVEIVEEKG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RL19_BACAC
Sequence: MQQLIAEITKGQLKTDLPSFRPGDTLRVHVKVVEGTRERIQLFEGVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPRIAKIEVLRRGKVRRAKLYYLRNLRGKKARIKEIR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: VF337_IIV6
Sequence: MIIRNFPKQTNSLLPFELNPNKFPSYYGYPMYGYTGSYRNIEFPISQNGNFLQATSGNPPGRRVPEPIYSSGVQRSTRINYLPSSQSCAPFQSHADCDKSPNSKGGESYDWNYGWSSCCSGFCPSKRECAKPDPKECDIGNDILDRDPLLKIEWDVNAPNYRCTYDLHKINTSEQINLFVGKNGKNKSYDEIMTSFCEIPSHICPIDPGDGSLNDDKRGKEMEKCSRLISLDDEGTRCRAWAATQDNKTIDNIKEEYCLHNPNSPDCRCINRSSNSLYDEAKKNNPFPDGCWYKPCSTSVYLKTSDILSDEKHCPKEMCQVIYNVNQNNDVVIKDNTNNIKCDFTKFIPPTPGPNPGPTPGPNPGPIIPPINPLPLPNPTFLENKNVLITGIAVTGVAVLLFLLLMFKSKTT
What are the official names of this protein?
Putative membrane protein 337L.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 337L family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein.
Protein: GEMI5_DICDI
Sequence: MNIDSNIIKNENLINANNHTDRRDVHDSLAEAPEKITELKKNHWEELLPSSSNWYCTSVADCNENQIYIYACKSNVSIFNIKSKKFIGELNGHTDRVTSVGFFKRFESKNDESYKWCITGSDDKTVRIWKFNSNDDDHNEDTEIGDDFKHGSGGGGSDGGGGDDVNNFYGNKSSNFCIYYHQEHKAGVTCVVASPLVPDLVLSGDKAGALVIYRTLTNHVFPIPPIIGNNISISTLAFSPNHSDLVAIGYLNGIVLIYNFVIRSTVCKISAHSADVLSIVWFDSTIIQKNNIFHDNNINDQDDNNSNHRNRIFLATCSKDKAIKIWKQVGEKIESGFTNIYQFNPSKYSIQHSSSSGGGGINQNDKQRVWLTLSWSPESPQYLLSNSLTADVLIWDLINFKSPPEKFQSSHQRLIFNITQIPNSDGSLAKTTATTETTTKNKIKNKDKKQSQIKLNNKVITVSLDRQIIIWENLKAKIKIQGLGGFVYSIDTCSYSPNTFAIGCGDNTIRLWSPTENSKDAYESKTLWKGIQSKVTSLSICKDYGFSNSNLIAFGMDDGRVGVYNINTNQSKIFPGGHKNEIYEIIWKPPPTPTPQKNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNNNNNNSNNEQQPNKLYSIGNNEIYEWDYNDFNKSFTNMTPIIQQLNPKETFSKHKTDINFNLNGDMISIGYSDGTIDIFTSEFLFLTRIREHKKLINRVQWNHFKENEMILASASTDKKVIIYKLSKIGNQNENEKKIDNEKGKENENEKGKENENENENENENENENENENEIENIVNNNNENDTEIEIKNINKNENVDKEEMVENNNNNNIKYKIEILHQFIGHKNNVCSVSWSNVDPNLLGSASADGTVQVWNIKSKEAISNMRGHDGRVFTVCWSLLDPNLLVSGGEDQTVRLWNYSTQPFKTVTESQIKKSPQPELSISLNKKITEQQQQQQQPQSPIKSNPDQSNNPSLVPPILLTSVTSTSNTTATATTITQITESLPKKRPIFLLNKDIVQRQDSSQYVVPLAKYFTTNDQDSINTNETKQEYEFGSNSENNNSKIEAIFSEKKEIINKLVQKESLELLKIDDVENYISLNSWNPANLKQALYQVIKNGKLTGNIVSLSIQAGREIFESICNLYSQQLICIGDYHLAVSYLLMIGKVNEAIEVYRNTLLFQEAIILAKSRFLPDDPIINKLFTEWAKQTETSHPIHSIKCYLATINDQSLNSKQELLKLLSSVQTKQIIKIQSDLEQILK
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.  Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex.  Binds to the 7-methylguanosine cap of RNA molecules (By similarity).
What are the official names of this protein?
Component of gems protein 5, Gemin-5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat gemin-5 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, gem. Cytoplasm. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Protein: DGAT1_HUMAN
Sequence: MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
What is the function of this protein?
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:9756920, PubMed:32433611, PubMed:32433610).  Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (PubMed:18768481).  In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:16214399).  Also present in female mammary glands, where it produces fat in the milk (By similarity).  May be involved in VLDL (very low density lipoprotein) assembly (PubMed:18768481).  In contrast to DGAT2 it is not essential for survival (By similarity).  Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399).  Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity).  Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705).
What are the official names of this protein?
Diacylglycerol O-acyltransferase 1, ACAT-related gene product 1, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, Diglyceride acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NDK_DESPS
Sequence: MEKTFAIIKPDAFAAGNAGKILARIYQEGFTVIGLKKLCMSQREAEGFYAVHNKKPFFAELTKFMSSGPCIVMVLEAEGCIGKWRDLMGATNPADAKPGSLRREFGTIVGENATHGSDAPETAAVELEYFFSGLELL
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_STRAW
Sequence: MTQDSYLVGLIGSGIGPSLSPALHEREAGRQGLRYHYRLIDIDRLGVGPEAVGGLVRAARDLGFDGLNITHPCKQLVISHLDTLAPQAEALGAVNTVVFEDGRAVGHNTDVTGFAASFARGLPDARLERVVQLGAGGAGAAVAHALLTLGAGHVTVVDALPERAAALAVALNRHFGDGRAAAASPDTLPKLLTDADGIVHATPTGMAAHPGIPLPAELLHPGLWVAEVVYRPLETELLRTARALGCATLDGGGMAVFQAVDAFRLFTGREPDSMRMLADIAELAGTAAVRH
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: TCAL7_MOUSE
Sequence: MQKSCNEKEGKPKGSEAKREDEQPCGALEGQRLEGNFRQRLLQSLEEFKEDIDYRHFKGEEMTGEEEEMERCLEEIRSLRKKFRALHSNRTHSRDHPF
What is the function of this protein?
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters.  Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression.  Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines (By similarity).
What are the official names of this protein?
Transcription elongation factor A protein-like 7, TCEA-like protein 7, Transcription elongation factor S-II protein-like 7.
What is the protein family that this protein belongs to?
Belongs to the TFS-II family. TFA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLMU_STAA3
Sequence: MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEEQLGTAHAVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQAEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQRRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDSFVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_BARHE
Sequence: MSISHSDTVLIIDFGSQVTQLIARRVRAMGVYCEVVPFQLALEGMQRIKPKAVILSGSPYSVIDEGSPRAPMEIFEMDIPVLGICYGQQIMCVQLGGKVASGHEREFGRAFLEVQENSALFEGVWEKGSCYQVWMSHGDRVTALPEGFRVIGTSKGAPYAAIADEKRRLYAVQFHPEVVHTLDGTKLLQNFVLKISNLKGNWSMASYREQTIAKIRQKVGKSRVICGLSGGVDSSVVAVLLHEAIGDQLTCILVDHGLMRKNEAQEVLTLFRDHYNIKLIHVNAANMFLNALEGEIDPEKKRKTIGRLFIEVFEEETKKIGGAEFLAQGTLYPDVIESISAIGKSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRSLGKELGLPEQFIGRHPFPGPGLAIRCPGAVTREKLEILREADAIYLDEIRKAGLYDEIWQAFAILLPVQTVGVMGDGRTYEFVCALRAVTSVDGMSADFYPYDMEFLSKTAARIINEVRGINRVVYDVTSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: SCR1_ORYSJ
Sequence: MGSSSLLLFPSSSSSATHSSYSPSSSSHAITSLLPPLPSDHHLLLYLDHQEQHHLAAAMVRKRPASDMDLPPPRRHVTGDLSDVTAAAAPSSASAQLPALPTQLPAFHHTDMDLAAPAPPPPQQQVAAGEGGPPSTAWVDGIIRDIIASSGAAVSVAQLIHNVREIIRPCNPDLASILELRLRSLLTSDPAPPPPPPPSHPALLPPDATAPPPPPTSVAALPPPPPPQPDKRRREPQCQEQEPNQPQSPKPPTAEETAAAAAAAKERKEEQRRKQRDEEGLHLLTLLLQCAESVNADNLDEAHRALLEIAELATPFGTSTQRVAAYFAEAMSARLVSSCLGLYAPLPNPSPAAARLHGRVAAAFQVFNGISPFVKFSHFTANQAIQEAFEREERVHIIDLDIMQGLQWPGLFHILASRPGGPPRVRLTGLGASMEALEATGKRLSDFADTLGLPFEFCPVADKAGNLDPEKLGVTRREAVAVHWLRHSLYDVTGSDSNTLWLIQRLAPKVVTMVEQDLSHSGSFLARFVEAIHYYSALFDSLDASYSEDSPERHVVEQQLLSREIRNVLAVGGPARTGDVKFGSWREKLAQSGFRVSSLAGSAAAQAVLLLGMFPSDGYTLIEENGALKLGWKDLCLLTASAWRPIQASGR
What is the function of this protein?
Transcription factor required for quiescent center cells specification and maintenance of surrounding stem cells, and for the asymmetric cell division involved in radial pattern formation in roots.  Essential for cell division but not differentiation of the ground tissue.  Regulates the radial organization of the shoot axial organs.  Restricts SHR movment and sequesters it into the nucleus of the endodermis (By similarity).
What are the official names of this protein?
Protein SCARECROW 1, OsSCR1.
What is the protein family that this protein belongs to?
Belongs to the GRAS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BAT41_CAEEL
Sequence: MEINNGAQPENAAVSIPSRSPSGKSEKRKSPSIVSGCRTVMNERSFTNYWSVERFTVQLELHNPAEFMLAPKFGDGDYEFVMKLFPNGKDEETAGYLSLFLLINKCPNPRLRFRVSFTVETADGPRSCHLNKNLVTINRSGIVTASKFFSLDILRSAMNVYIPNDILTIGCELTIFGECTTQISSLFKPYQRTHSASSTSRSLSSPNTKCLKIDESSAHDAFTEFLSTGEFSDFIIVASCGREFPTHMCILAARSEYFKVLLRNHSTKEFMSKRLQFDDISARTLDVLLRHMYASAAGRVVKLEEDQLTEDLISAMDRLMINSLRDEVARLIGSKVTVDNVLTRISMAAELRLDDTYDVLLDFFSNHKHECMKLTAWDELESAKPPLAIKILRDAFSNTDSPSTTSMDSRIIDRITLT
What is the function of this protein?
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
BTB and MATH domain-containing protein 41.
Protein: RECF_STRSY
Sequence: MWLERLELQHFRNYNQLDIEFHKGLNVFLGENAQGKTNILESIYVLALTRSHRTRTDKDLLQFQEKELSISGLLHRTSGKVPLDIHLTDKGRVTKVNHLKQAKLSNYIGHMNVVLFAPEDLQLIKGAPALRRKFIDVELGQIKPLYLSDLSNYNHVLKQRNTYLKSTDKIDENFLSVLDQQLAEYGSRVIQHRIDFLKKLEEFGNRKVQEISGNREELTIEYQTSIELTDDVNLIDKFLTELEKSRKRDLFKKNTGVGPHRDDVAFFINGMNAHYASQGQHRSLVLSLKLAEIELMKEVTREYPILLLDDVMSELDNNRQIKLLETITDTIQTFITTTSLDHLHKLPDSLKIFHIESGKVTESE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_RUEPO
Sequence: MKRTYQPSNLVRKRRHGFRARMATKAGRKILNARRARGRKELSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: GET4_ORYLA
Sequence: MSDPESLRCSSVRNRGGVQRVEGKLRASVERGDYYEAHQMYRTLFFRYMSQAKHAEARELMYRGALLFFSHNQQNSAADLSMLVLEVLEKSDAKVEDEILEHLAKLFSLMDQNSPERAAFVSRALKWSTGGSSKLGHPKLHQLLALTLWKEQNYSESRYHFLHSSDGEGCAQMLVEYWASRGYRNEVDLFVAQAVLQFLCLKNKSSASVVFSTYTEKHPSIQKGPPFVQPLLNFIWFLLLAVDGGKLTVFTVLCEQYQPSLKRDPMYNEYLDRIGQLFFGVPPKQSPSYGGLLGNLLNSLMGSGEDDDGVEEAQEDSSPIELD
What is the function of this protein?
As part of a cytosolic protein quality control complex, the bag6/bat3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation.  The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane.  Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum.  The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome.  It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
What are the official names of this protein?
Golgi to ER traffic protein 4 homolog, Conserved edge expressed protein.
What is the protein family that this protein belongs to?
Belongs to the GET4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: CYB_POLSP
Sequence: MANIRKTHPLLKIINGAFIDLPAPSNISVWWNSGSLLGLCLITQILTGLFLAMHYTADISTAFSSIAHICRDVNYGWLIRNIHANGASFFFICLYLHVARGMYYGSYLYKETWNIGVVLLLLTMMTAFVGYVLPWGQMSFWGATVITNLLSAFPYIGDTLVQWIWGGFSVDNATLTRFFAFHFLLPFVIAGASMIHLLFLHQTGSNNPTGLNSDADKVPFHPYFSYKDLLGFILMLIGLTAIALFSPNLLGDPDNFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLFSILVLMLVPILHTSKQRGNTFRPLSQILFWTLVADMLVLTWIGGQPVEHPFVLIGQVASTIYFALFLIALPLTGWLENKILNWN
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TOPB1_HUMAN
Sequence: MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH
What is the function of this protein?
Required for DNA replication.  Plays a role in the rescue of stalled replication forks and checkpoint control.  Binds double-stranded DNA breaks and nicks as well as single-stranded DNA.  Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters.  Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage.  Induces a large increase in the kinase activity of ATR (PubMed:16530042).
What are the official names of this protein?
DNA topoisomerase 2-binding protein 1, DNA topoisomerase II-beta-binding protein 1, TopBP1, DNA topoisomerase II-binding protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner.
Protein: RS4_METB6
Sequence: MGYPGKNHKSYQTPKRPFEKTRIEEETRLVIEYGLRNKREVWKAQSHLRKYRKAARELLALMSSATNQTVFEAKKSELISHMQRAGLLGPDADIDNVLALKVPAQLERRLQTLVYRKGLARSPKQARQLVTHGHIAIGGRRVTVPGYLVTRGEETTISYAGKSPFVDASHAERTRITRPTGAGVN
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: TOLB_ECOLU
Sequence: MKQALRVAFGFLILWASVLHAEVRIVIDSGVDSGRPIGVVPFQWAGPGAAPEDIGGIVAADLRNSGKFNPLDRARLPQQPGSAQEVQPAAWSALGIDAVVVGQVTPNPDGSYNVAYQLVDTGGAPGTVLAQNSYKVNKQWLRYAGHTASDEVFEKLTGIKGAFRTRIAYVVQTNGGQFPYELRVSDYDGYNQFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHNGAPAFSPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLAFTSDQAGRPQVYKVNINGGAPQRITWEGSQNQDADVSSDGKFMVMVSSNGGQQHIAKQDLATGGVQVLSSTFLDETPSLAPNGTMVIYSSSQGMGSVLNLVSTDGRFKARLPATDGQVKFPAWSPYL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.  TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PURNU_DEIRA
Sequence: MTAPGLPLLRAPNLAVPHAFTTRAGGVSAGPYAGLNLDDRSDDPRPVAENRARLAAALGFAADDFARLNQVHGVQVVHAQAPGFWEGDALVTATPGVLLAIGTADCYPLLLADPEAGVIGAAHAGWKGTVGRIGQRTVEQMVNLGARPERIHAAVGPGICGEQYEVGEDVAAQFRAAGLGEWVLEREGRTHLDLAGANRALLEGAGVGDLWVSGRCSTEADFYSYRRDAGQTGRMWAVIGLPRREGQTGEARA
What is the function of this protein?
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine.  Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate.  Also has adenosine deaminase activity.
What are the official names of this protein?
Purine nucleoside phosphorylase DR_1966, Adenosine deaminase DR_1966, S-methyl-5'-thioadenosine phosphorylase DR_1966.
What is the protein family that this protein belongs to?
Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.