PharMolix/UniProtQA huggingface dataset:
Protein: LIMK1_RAT
Sequence: MRLTLLCCTWREERMGEEGSELPVCASCSQSIYDGQYLQALNADWHADCFRCCECSTSLSHQYYEKDGQLFCKKDYWARYGESCHGCSEHITKGLVMVGGELKYHPECFICLACGNFIGDGDTYTLVEHSKLYCGQCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASAHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHIGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDSLGHGPVSDPSPLASPVHTPSGQAGSSARQKPVLRSCSIDTSPGAGSLVSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKGQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETLRMHLAGHLPLGPQLEQLERGFWETYRRGESSLPAHPEVPD
What is the function of this protein?
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics.  Acts downstream of several Rho family GTPase signal transduction pathways.  Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop.  LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton.  In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation.  Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly.  Stimulates axonal outgrowth and may be involved in brain development.
What are the official names of this protein?
LIM domain kinase 1, LIMK-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner.
Protein: SURE_PARD8
Sequence: MTNERPLILITNDDGVWAKGINELIECLKDLGDLVVFAPDGPRSGMGSAITSLVPIKYTLLKKEEGLTIYSCTGTPVDCVKLAINEVLERKPDLLVSGINHGGNMAICVNYSGTMGAAAEGCIFNVPSMGVSLLDHAADADFSECCRLGRMLARRVLKEGLPHGTYLNLNVPKLPQVKGLKVCRQADGRWVREFKRSENASGEPVFWLTGAFESAKPIHPDNDMLALDSGYASLVPCKIDVTDYDFMATLNNWIL
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMX_BACSC
Sequence: MKQDMIDYLMKNPQVLTKLENGEASLIGIPDKLIPSIVDIFNKKMTLSKKCKGIFWEQ
What is the function of this protein?
Part of a major quorum-sensing system that regulates the development of genetic competence (PubMed:12067344).  Acts through the activation of the two-component regulatory system ComP/ComA composed of a sensor histidine kinase, ComP, and a response regulator, ComA (By similarity).
What are the official names of this protein?
ComX pheromone, Competence pheromone.
What are the subcellular locations of this protein?
Secreted.
Protein: KAD_COXBR
Sequence: MPLRIILLGLPGAGKGTQADFIAKHLDIPKISTGDMLRAAVKAKTPLGLEVKKIMESGGLVSDEIMIALVKERVKLPDCHKGYLLDGFPRTLAQADALNAAAIKIDLVIEIDVPEEEIIERMTGRLIHPASGRTYHRRYNPPKVADKDDVTGEPLIQRADDREETVRHRLAVYRKQTSPLSDYYAQWEKSGDPQAPKYFRISGLGSMEEVRERILQVFEAYDPRDSGNLEH
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOD2_STRM5
Sequence: MSHVHQAGEAFASSPAESRQEIRNYTMNFGPQHPAAHGVLRLILEMDGETIMRADPHVGLLHRGTEKLAESKPFNQSIGYMDRLDYVSMMCNEHAYVRSIETLMGIEAPERAQYIRTLFDEITRILNHLMWLGSNALDLGAMAVMLYAFREREELMDCYEAVSGARMHAAYYRPGGVYRDLPDHMPKYKESRWHKGKALKNLNAAREGSLLDFLENFTNEFPGRVDEYETLLTDNRIWKQRTVGIGVVTPELAHQWGMTGVMLRGSGIAWDLRKKRPYAKYDAVDFDIPLGKEGDCYDRYLVRIAEMRESNRIIKQCVAWLKANPGPVMVKNFKVAPPKREDMKDDMEALIHHFKLFSEGYCVPAGETYAAVEAPKGEFGCYLVSDGANKPFRVHLRAPGFAHLSSIDSIVRGHMLADVVAMIGTYDLVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D 2, NADH dehydrogenase I subunit D 2, NDH-1 subunit D 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RR4_IRIEN
Sequence: RFKKIRRLGALPGLTSKRPRSGSDLKNQLRSGKRSQYRIRLEEKQKLRFHYGLTERQLLKYVHIAGKAKGSTGRVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGHIVDILSYRSKPRDIITTKDNQRSKALIQNYLAWSPHEELPNHLTMDPFQYKGLVNQIIDSKWIGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSBT_NOSP7
Sequence: MESVAYILIFTLCIGTIFFAIAFREPPRFEKPKDK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: ENOPH_DROER
Sequence: MTSSERMAKVVLVDIEGTTTSISFVHDILFPYAKQNVEKFLRNSWEEDDIQHIVQDLQQVPQFADYKALLSAPPAEVDFELIAGFVRYLIDQDLKVTPMKTLQGLIWAQGYTNGELKGHVYEDVPTAFKAWRAAGLQIAVYSSGSVAAQKLIFGHSLVGNLQPYLSAYFDTHVGHKQEQQSYETIAKLLKEDPKHILFLTDIPGEAAAARSAGLQAIILQRPGNAALADDQKASFELIPDFKPLQNLKLPLNKYQA
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: QUEC_CAMFF
Sequence: MVNLKKAVCVISGGMDSALAAYKAKNSGYEIVALHFDYNQRTMNKERECFNLICDDLDVEKRFILDVGFIAQIGGNALTDKTLNIPKDGISENIPITYVPFRNGIFLSIAAALAQKEGCEAIYIGVVEEDSSGYPDCTEQFINSINKAINLGTADNNIVIKTPLVHLSKGDIVKEASSLKVPLELTWSCYENSEFACGTCDSCRLRLKGFKEAKLSDKIPYKS
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RL23_RHILO
Sequence: MTDLRHYDVIVSPAITEKSTMASEQNQVVFNVAKKASKPEIKAAVEALFGVKVMAVNTLVRKGKIKRFRGTIGRQSDVKKAIVTLADGQSIDVATGL
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: UXUA_YERP3
Sequence: MEQTWRWYGPNDPVSLDDIRQAGATGVVTALHHIPNGVVWPVSEIKQRQAELAAKNLVWSVVESVPIHEDIKTHSGNYQQYIENYQQTLRNIAECGIDTVCYNFMPILDWTRTDLEYELPDGSKALRFDQIAFAAFELHILKRPGASNDYTAEEQVQAEAYFNAMTEADIAKLTGNIIAGLPGAEEGYTLDQFRARLAEYDGIDKAQLRENMAYFLRAIIPVAEQVGLRMAVHPDDPPRPILGLPRIVSTIEDMQWLKETVDSIHNGFTMCTGSYGVRADNDLVKMIETFGDRIHFTHLRSTCREGNPKTFHEGGHLQGDVDMYSVVKAILTEEQRRQSLGDMRPIPMRPDHGHQMLDDLHKKTNPGYSAIGRLKGLAEVRGVELALKRTFFPDLKQ
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: CYB6_SORBI
Sequence: MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTEAFSSVQYIMTEANFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLAVLTASFGVTGYSLPWDQIGYWAVKIVTGVPEAIPVIGSPLVELLRGSASVGQSTLTRFYSLHTFVLPLLTAVFMLMHFPMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: TRPA_HALS3
Sequence: MTRSDLAAAFDDGPALVSYVVAGDPTPAATAEYIDALVDGGTDVIELGLPFSEPVAEGTTIQNAIKRALDAGMTPDAYLDLVARIDADVPVVCMTYYNLLFQYGDRAGPAAFVSAAAEAGVSGFVVPDLPVDESGPLREACRAHGLDLVFVVAPTTTADRRERMLDLTTGFVYVQGRVGTTGAREEVSAATPDALAALQHTDIPKAVGFGVSSGEQAREITASGADGVIVGSAYVDTVADGVADDDPPSVVADRLRDLAAELKAGAARGVPEPEHK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: UTP25_NEUCR
Sequence: MAIRGRGGDRGGGGRGGGGRGRGGAGGFRGRGGSRGGGSRGGARGASRGRGRGSSRGGARGGFGPRSSKFNDARLADKDEEEDEEEDISEEESNVSEDEIEESEEEDEEEDAQSGQPYMSLLKSFQSATKTKKRKLDHPEEEGPNKVTKTKDDDNSDDEDNEKVTEDVDAVDEPEEDPQDAPLEDLFDEDDDLDDSDPFETHFTAPDEATFQARIKAIQANKWRTDRIAKNSNRIYYNTPETGDSAEQKLPHSISGVGDLKLKQRLAESMAKHTEFDEAEKAVAPLLFNYQDMLYCNRSVASSESIRRMACLHALNHVFKTRDRVIKNNTKLQRDDTLELRDQGFTRPKVLMILPTRQSCVKMVEMICKVAAPEQQENRKRFDDGYVDKSTKFSDDKPEDFRDLFAGNDDDMFRLGMKFTRKTIKYFSQFYNSDIIFASPLGLRMAIGSEEEKKKLDYDFLSSIELVIVDQADALLMQNWEHVEFIFEHLNLQPRDAHGCDFSRVRSWYLDDQAKYFRQTVIFSAFNTPELAELQRLYCHNWAGKARLQAEYPGVIQYLGVKTRQTFSRFDAASIAADPDARFAYFTKAIVPTLVKRAAKDAAGTLIFIPSYLDFVRVRNYFANNPAVESVTFGNISEYADTPEASRARSHFLTGRHRVLLYTERAHHFRRYAIKGVKRVIFYGLPDNPIFYREIAGGYLQKSEQALMLEHGQGHVKVMFSKYDIMKLERIVGTKRAGKMITEQGDTFDFV
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: AROQ_RHILO
Sequence: MKTVFVLNGPNLNALGKREPGIYGGKTLAAIADDCKQAGASLGLGIDFRQSNHEGDLVDWIQEAGDKAAGIVINPGAYSHTSIAIHDAIRSIAPLPVAEVHLSNIHARESFRHVSMVAPVAVGMICGFGPLGYTLALQALAARL
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: NUOH_JANMA
Sequence: MDQLFASIHATGQSLLGYYWPLVWNLVKIIAVVAPLMGAVAYLTLWERKVIGWMHVRHGPNRTGPAGLLQPIADGVKLLLKEIVVPAKSSKALFVIAPIMTIMPALAAWAVIPFGPETVLADVNAGLLFVMAITSLEVYGVIVAGWASNSKYAFLGAMRASAQMISYEIAMGFVLVIILMVTGSMNLTTIVNTQNTGRFAEMGLTFLSWNWLPLLPMFFIYIISGTAELNRHPFDVVEGESEIVAGHMVEYSGMSFAMFFLAEYANMWLISIMATLMFLGGWTSPIDMAPFTWVPGWIWLGLKTLMVVTMFIWFRASFPRYRYDQIMRLGWKVFIPLTLVYLLIVAIWMKTPWNIWN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEUC_FRASN
Sequence: MGRTLAEKVWDAHVVRRADGEPDLLYIDLHLVHEVTSPQAFEALRLAGRPVRRPDLTLATEDHNVPTTDTLLPIADPVSRAQVEALRKNCADFGVRLFPMNDPDQGIVHVVGPQLGLSEPGMTIVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPQRRPKTMAVTVQGELPAGVTAKDLILAVIARIGTGGGAGYVIEYRGEAVRGLSMEGRMTVCNMSIEAGARAGMIAPDETTFEYLRGRPNAPTGADWDAAVEYWRTLATDPDATFDHEVVIDGPSLSPYVTWGTNPGQAAPLSSPVPDPAAYADPAARGSVERALAYMDLVPGTPLSDVAVDTVFIGSCTNGRISDLRDAADVLRGRQVADGLRVLVVPGSMAVKAEAEAEGLDEVFRAAGADWRSAGCSMCLGMNPDTLRPGERSASTSNRNFEGRQGPGGRTHLVSPAVAAATAVTGRLTAPADL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RL22_RUTMC
Sequence: MKEVKAIHKYAKTSAFKVRLVANQIRLKSVDEALNILSFSNKKAAVLIKKVLNSAISNAEHNDGLDIDELFVASICIDEGSTMKRIRPRAKGKANRILKRTSHITVGVSK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RPIA_SALAR
Sequence: MTQDELKKAVGWAALQYVQPGTIVGVGTGSTAAHFIDALGTMKGQIEGAVSSSDASTEKLKGLGIHVFDLNEVDSLGIYVDGADEINGHMQMIKGGGAALTREKIIASVAEKFICIADASKQVDILGKFPLPVEVIPMARSAVARQLVKLGGRPEYRQGVVTDNGNVILDVYGMEILDPIALENAINAIPGVVTVGLFANRGADVALIGTPDGVKTIVK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: RECF_STRM5
Sequence: MQIRRLALHQLRRFNAVELSPQPGLNLLTGDNGAGKTSILEALHLMAYGRSFRGRVRDGLVRQGQEALEIFVEWDEQRASHPPHRRKAGLRHSGQDWKGRLDGEDVAQLGNLCAALAVVTFEPGSHALVSGGGEPRRRFLDWGLFHVEPDFLSLWRRYSRALKQRNALLKQGGPSRMLDTWDHELAEAGEPLTSRRQHYLERLQQRTVALAAELAPQLGIQAMELSPGWRRHELPLADALLLARERDRQAGYTSVGPHRADWSVDFHNIPGRDALSRGQAKLTALACLLAQAEDYAEQRGEWPVIALDDLASELDRTHQARVLERLLGGPAQIFVTATETPAALQELTHIARFHVEHAQIVAVP
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECD_HAEIN
Sequence: MLSVLHKLKELRILSQGDYYFAKLIADKQCHTDYAEPVKNLAILLAALCSWRYTQGNTCSQLDRYLEHNLFGLAYRTTEEDYLAEIHEKIGYLPVEDWQNALCGHMAFTQDPVNQIAPMAFQFGALYFYRAWQDEYRIVQYIKNTLKKYRTLAFSYDEIHQKLEKYFPEKQEKTDWQKVAVATAIKSPFSIITGGPGTGKTTTVTRLLLVLQELFDCKLHIKLVAPTGKAASRLEESIKNALGFMQEKMNVSHSLFNAIPQKASTLHSLLGVNAFNDYTRYNSHNPLQLDVLVVDETSMIDLPMMAKLINALKPETRLILLGDQAQLASVEAGAVLGELAQFVTQPYSHEQAAYLLATTGYKVEGSDCSNPIRDCLCHLTESRRFDKDSGIGKLSEFIQKGKADDSLELFDHYPQELHFNSLNDEGDAVNQVVKSAVENYRTFLKMLDDLRKQKIDPNAKNEQGISYAEAIQVQFNSVRFLTALRNNNLGVENLNKEIALALREQKLLWFRNEQDWYIGKPIMITENDHNVRLYNGDIGLCLANGKVWFGNREVLTNRIPAHEPAFMMTIHKSQGSEFKHTVMVLPTEVNPVLSRELVFTGVTRAKKELTVFADEKIWKTAIRQTVKRQSGLGKLLEDLN
What is the function of this protein?
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair.  Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity.  Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction.  Cuts ssDNA a few nucleotides 3' to the Chi site.  The properties and activities of the enzyme are changed at Chi.  The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair.  Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination.  In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity.  When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity.  Negatively regulates the RecA-loading ability of RecBCD.
What are the official names of this protein?
RecBCD enzyme subunit RecD, Exonuclease V subunit RecD, ExoV subunit RecD, Helicase/nuclease RecBCD subunit RecD.
What is the protein family that this protein belongs to?
Belongs to the RecD family.
Protein: AROB_LEGPC
Sequence: MAKFELYAEVDVSISGHQYPIIICRNGLIDPELINRFITSKQVLIVTNRTVAPLYLGHLQSGLPSKQCDVVILEDGEEHKNQRSLFTIYDSLIQNKHHRDTSIIALGGGVIGDMAGFAASTYQRGVRFIQLPTTLLAQVDASVGGKTAINHPAGKNMIGSFYQPQAVIIDLNTLKTLPEREFRAGIAEMIKYALLVGGPFFERIQAVLQQGLTVHSPELPLLIAECCQVKAKIVEQDERESGLRALLNLGHTFAHALETYTDYKKWLHGEAVAIGLYCAAVLSEKKGLLDKPIVDQVEKMLIHAGLPHKIPNSIDLIQLRELMSLDKKIKNNCLRFVMIKKPGACYIDDSVTEDCLHNTLINVVEGEQK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DMPK_PSEUF
Sequence: MTVTNTPTPTFDQLTRYIRVRSEPEAKFVEFDFAIGHPELFVELVLPQDAFVKFCQHNRVVAMDEAMAKAVDDDMVKWRFGDVGRRLPKDPG
What is the function of this protein?
DmpK is an auxiliary protein associated with the multicomponent phenol hydroxylase DmpLMNOP and it may be involved in the post-translational incorporation of iron into the oxygenase component of the phenol hydroxylase (PubMed:8995386).  Required for growth on phenol but not for in vitro phenol hydroxylase activity (PubMed:2254258, PubMed:2254259).
What are the official names of this protein?
Phenol 2-monooxygenase, auxiliary component DmpK, Phenol 2-monooxygenase P0 component, Phenol hydroxylase P0 protein.
Protein: RS6_CHLPN
Sequence: MGKKENQLYEGAYVFSVTLSEEARRKALDKVISGITNYGGEIHKIHDQGRKKLAYTIRGAREGYYYFIYFSVSPGAITELWKEYHLNEDLLRFMTLRADSVKEVLEFASLPE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: Y7237_PSEAB
Sequence: MLSWAITFLIIAIIAAVLGFGGIAGAATGIAKILFVLFLVLFVVSFFFGRRRG
What are the official names of this protein?
UPF0391 membrane protein PA14_72370.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SSR4_MOUSE
Sequence: MNAPATLPPGVEDTTWTPGINASWAPDEEEEDAMGSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFARSAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLATATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLPPVLAIGLCYLLIVGKMRAVALAGGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGAGCICPPLPCQQEPVQAEPGCKQVPFTKTTTF
What is the function of this protein?
Receptor for somatostatin-14.  The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.  It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.
What are the official names of this protein?
Somatostatin receptor type 4, SS-4-R, SS4-R, SS4R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RB11A_CANLF
Sequence: MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  The small Rab GTPase RAB11A regulates endocytic recycling.  Acts as a major regulator of membrane delivery during cytokinesis.  Together with MYO5B and RAB8A participates in epithelial cell polarization.  Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.  Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells.  Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane.  Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (By similarity).  Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (PubMed:19451275).  May also play a role in melanosome transport and release from melanocytes (By similarity).
What are the official names of this protein?
Ras-related protein Rab-11A, Rab-11.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle membrane. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis.