PharMolix/UniProtQA huggingface dataset:
Protein: VP4_ROTAP
Sequence: MASLIYRQLLTNSYTVELSDEIQEIGSTKTQNVTVNPGPFAQTNYAPVNWGPGETNDSTTVEPVLDGPYQPTTFNPPVSYWMLLAPTNAGVVVEGTNNTNRWLATILIEPNVQQVERTYTLFGQQVQVTVSNDSQTKWKFVDLSKQTQDGNYSQHGSLLSTPKLYGVMKHGGKIYTYNGETPNANTGYYSTTNFDTVNMTAYCDFYIIPLAQEAKCTEYINNGLPPIQNTRNIVPVSIVSRNIVYTRAQPNQDIVVSKTSLWKEMQYNRDIVIRFKFANSIIKSGGLGYKWSEVSFKPANYQYTYTRDGEEVTAHTTCSVNGVNDFNYNGGSLPTDFVISKYEVIKENSFVYIDYWDDSQAFRNMVYVRSLAADLNSVMCTGGDYSFALPVGNYPVMTGGAVSLHSAGVTLSTQFTDFVSLNSLRFRFRLSVEEPPFSILRTRVSGLYGLPAAKPNNSQEYYEIAGRFSLISLVPLNDDYQTPIMNSVTVRQDLERQLGELRDEFNNLSQQIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSMATNVMKRFKKSSLANSVSTLTDSLSDAASSISRSASVRSVSSTASAWTEVSNIASDINVTTSSISTQTSTISRRLRLKEMATQTDGMNFDDISAAVLKTKIDKSTQLNTNTLPEIVTEASEKFIPNRAYRVIKDDEVLEASTDGKYFAYKVETFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYGISRQQALNLLRSDPRVLREFINQDNPIIRNRIESLIMQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: RL15_RHOBA
Sequence: MQLNDVHRGITKHRPRKRIGRGPGSGTGKTSGRGHKGHKSRSGYSRKPNFQGGAMPMFRRVPKRGFNNRWALTIFAVNVGKLNDAFNEGETVTLEALAAKNLAKGNFDELKVLGDGELTKKLTIQAHRFSKSAEEKISAAGGTAEKLAPKRTPDERVEALKSEK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: GLMU_ERWT9
Sequence: MSNRPMSVVILAAGKGTRMYSDLPKVLHLLAGKPMVQHVIDAARELNAQRVNLVYGHGGELLKTALDDRSLNWVLQAEQLGTGHAMQQAAPYFADDEDILMLYGDVPLITGETLRRLQAVKPDGGIGLLTVNLANPTGYGRIIRENGRVVGIIEQKDAAPEQLAIGEINTGILLAGGADLKRWLSKLTNNNAQGEYYITDIIALAHQEGRQIEAVHPVRTTETDGVNNRLQLATLERVYQAEQAEKLLLSGVMLQDPARFDLRGTLEHGRDVVIDTNVIIEGHVKLGNRVKIGSGCVIKNSVIADDCIISPYSVIEDAQLAPDCSVGPFARLRPGSELAEGAHVGNFVEMKKARLGKGSKAGHLSYLGDAEIGANVNIGAGTITCNYDGVNKSKTIIGDDVFVGSDTQLIAPVSVAAGVTIAAGTTIMRNVPAAGLVYNRKEQQLNASWQRPQKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GN_BHV1C
Sequence: MPRSPLIVAVVAAALFAIVRGRDPLLDAMRREGAMDFWSAGCYARGVPLSEPPQALVVFYVALTAVMVAVALYAYGLCFRLMGASGPNKKESRGRG
What is the function of this protein?
Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity.  Also plays a critical role in virion morphogenesis.
What are the official names of this protein?
Envelope glycoprotein N.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein N family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Host Golgi apparatus, host trans-Golgi network. Note=When coexpressed with gM, localizes in the host trans-Golgi network.
Protein: NAGZ_XYLFM
Sequence: MLLIGVAGTTLSAQEVDWLQDDAVAGVVLFKRNFASRAQIVELSAALREAAPRPLLLAVDQEGGRVQRFYEGYSALPPLQGIGALYVRDPEAALELAFEHAWLMASEVRASGVDLSFAPVVDLGRGNRAIGDRAFSDDPHVVAAFAQAYVQGMHAAGMPVTLKHFPGHGSVLEDTHVDLAVDVRPLETLESEDLVPFAAGIAAGADAVMMAHVVYPNVAPETAGFSAHWIEVILRGRMGFRGVVFSDDIGMAAVRGVGGVVGCVHAHLDAGCDVVLVCHPELVNDALSAVAGRRSNTAALIGLIGRGALGWDGLLADVRYGSIQSRLFERFGTST
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAA_SALSV
Sequence: MSIKEQSLMTPYLQFDRSQWAALRDSVPMTLTEDEIAQLKGINEDLSLEEVAEIYLPLSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRRVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPVYSHLIYDVIPEGDKTVAQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEELLQTWYINRFLKFREGAFTDPDSYFHNYAKLSKEEAVNTAASLWKEINWLNLKQNILPTRERASLIMTKSANHAVEQVRLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_LEIXX
Sequence: MIGAGSWGTTFAKILADGGNDVVVWARRPELAREIDEGKRNSDYLQGINLPRSLRATSHLGEAMRGAEQVFVSLPSQTLRSNLDAMIPYLGPATVVISLMKGVEKGTGLRMSEVIAQGLPIDPEQIAVVSGPNLALEIAREQPTAAVVSSVSPATAVAVATSATNRYFRSFVNTDVIGTEFGGVLKNLIAVAIGIVDGVGYGENTKASIITRGLVEMTDFAVAYGADPQTLSGLAGLGDLIATCESPLSRNNTAGRLLGQGYSFTDVVKQMDQAAEGLASVTPILSLAEARGVEMPIVRQVSQVLAGTLAPKDIAPHLTTDDEPQGERTRGERTTDDGQGQGRTSVWGSLKRAFDQLRDGGGSSRRDRP
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAH_ORYSJ
Sequence: MALLLSYPRRHPSIHLLILSAYALFLLPILDGLELGGDGLYREILRDETVLRLKELGKISDGEGYLERTFLSPASIRASAVIISWMKDAGLTTWIDQMGNIHGRFEPTNSTKEALLIGSHMDTVIDAGMYDGALGIISAISALKVLKVTGRLQRLTRPVEVIAFSDEEGVRFQTTFLGSAAVAGTLPESILQVSDKSGTTVQDVLKLNSLEGTANALGEVRYSPESVGSYVEVHIEQGPVLEALRYPLGVVKGIAGQTRLKVIINGSQGHAGTVPMKLRRDPMVAAAELVLTLETLCKEPNKFLTYDEECGCFTEESLAGLVCTVGELLTWPSASNVIPGQVNFTVDIRAMDDKVRETIVTSFSRLVLQRCDDRLVDCAVEQKHAAAATPCDAELTSRLERATRSTISSMAAGVRRAGGETPVLMSGAGHDAMAMARLTKVGMLFVRCRGGVSHSPEESVMDDDVWAAGLALVNFIDQNAVDAAAATAAES
What is the function of this protein?
Involved in the catabolism of purine nucleotides.  The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.
What are the official names of this protein?
Probable allantoate deiminase, Allantoate amidohydrolase, OsAAH.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: RL28_CUPNH
Sequence: MARVCQVTGKAPMVGNNVSHANNKTKRRFLPNLQNRRFFVESENRWVSLRVSNAGLRLIDKKGIDSVLADLRARGEV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: MNMG_CLONN
Sequence: MSYFAGEFDVAVIGAGHAGCEAALASARLGVSTVVFATDLASVAMMPCNPNIGGTAKGHLVREIDALGGEMGINIDHTYIQSRMLNTSKGPAVHSLRAQADKRKYAERMKHVLETTDNLHLKQAEIIKVDIEDSKVKGVLTKNGAYYKVKAAILCTGVYLKSRIIIGDINYEGGPSGLAPANMLSQSLIESGIKITRFKTGTPARINRRTVDFSKMIEQKGDENIVPFSFMSENIEREQISCYLTYSGDETKKVVLENIDRSPLYNGSIKSVGPRYCPSFEDKIMRFPEKDKHQIFIEPEGENTEEMYVGGMSSSLPEDVQLKMLRSVPGLENAEMMRTAYAIEYDCIDPTQLELSLEFKDIDGLFSAGQMNGSSGYEEAGCQGLIAGINAALKLQGKEPLILKRSDAYIGVLIDDLVTKGTQEPYRMMTSRAEYRLLLRQDNADLRLTEMGHKIGLVKEDRYERFTKRKTAIEDEIERLKNIQITNKQEVNKFLEGLNSAGLKKPISLYELIKRPELNYFVVKDLDKDRAELPRDVQEQVNIISKYEGYIQKQLEQVEQFKKLENRLIPKEFDYKLVKGLRTEAIQKLDKIKPVNIGQASRISGVSPADISVLLIVLEQYNRNKGHKEEEF
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRTC3_ONCMY
Sequence: MPRRRRASRPVRRRRRPRVSRRRRRGGRRRR
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Protamine CIII, Protamine PPC 6B.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RNC_SULNB
Sequence: MNDYSQLEKRLNYTFKDKQLIIEALTHKSYKKPYNNERLEFLGDAVLDLIVGEYLFKKFPKSDEGILSKIRASLVNESGFTLLARKIDLGSYIYLSLAEENNNGRDKPSLLSNAFEAIIGAVYLEAGLDTAKEISIKLLEECHPKIDLQSLSKDYKTALQELTQATHAVTPGYEMLGSSGPDHKKEFEIAVTLDNKTIATAKGKSKKDAQQKAAKIALEALKK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_PARUW
Sequence: MSVKYGKFEMPHKITVDQESPESNFARYVAEPFERGFGHTIGNALRRMMLSSLEAPAIISVRVEGIPHEYMAIEGISEDMTNIILNFKGALLRKLPTEETPRDTRILTKVVEVTQDDLDRNQGQYCVTLQDVVQEGNFEIVNPELHLFTVTKPMRRQVDLRIAFGRGYVPSERHVVRDKTSDEILVDAAFSPVRLINYFIENTRVGQDTDFDRLIMEVTTDGRITPAEALSFAVQIGLKHFEVFNQFNNYALSFDEKDGDRNGDQDELMDKLSLGIDEIELSVRSANCLTGANIETLAELVCIPERRMLEFRNFGKKSLNEIKAKLHEMSLHLGMDLSRFGVSPDNVKDKIKQYREEKKKKKELVKHEDAK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RLMH_PSYIN
Sequence: MKIQLIAVGTKMPDWVEKGYQEYARRFPKEMQLELLEINAGKRGKNADIKRILKKEGELTLAAIPKGNKIVTLEVTGQAWTTEQLADEMGKWQLDARNISLLIGGPEGLAPECITKSEQRWSLSALTLPHPLVRVIVAESLYRAFTLTINHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DF263_ARATH
Sequence: MEKTSLKLVFLFSLTVIALCLSLSAAREMAKEEVNCIGGHCPDGKKDCNCLPLIAPTMDIYETNESCRTDNECIKYCPKGCKIVDCNFGTCLCEYC
What are the official names of this protein?
Putative defensin-like protein 263.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: IL16_BOVIN
Sequence: MDYSLETTAEDPWVRISDCIKNLFSPIMSENHNHVPLQPDAPLGEEDGMRGHPDGAAAKLDTTGGGPKAYKQAGGSTVKKGPPVAPKPAWFRQSLKGLRNRVPDSRREMAASCQPTPTSRERPGPPLRASSSIKQRISSFETFSSAHPPDRGAQRLSLQASSSSGEAAELPRKQEGERASGPSGQGAPPTMEQQRPEPEQLPPASPATSEASNPGVSGHPPLEQQPGQKTLSSDPDPLSRLLATQMEGPRGPVVKMPSQRARSFPLSRTQSCEMKPLDEKTSKLYSISSQVSSAVMKSLLCLPSSLSFGQIPCSPKEGVLPPTAFSEDPTNSSAEASASDTSFSLNLSELREYTEGLSESTEANDCDHCTSQPGQSVISLLSTEELKKLIEEVKVLDEATLKQLDSIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGATHNDALAILRQAREPRQAVIVTRRPTLEATTDLNSSTDSSGSASVTSDVSIESAEATVCTVTLEKTSAGLGFSLEGGKGSLHGDKPLTVNRIFKGLASEQSDTVQPGDEIVHLAGTAMQGLTRFEAWNIIKALPDGPVTIVLRRKSLQSKGTPAAGDP
What is the function of this protein?
Pro-interleukin-16 is involved in cell cycle progression in T-cells.  Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene.  May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells (By similarity).
What are the official names of this protein?
Pro-interleukin-16.
What are the subcellular locations of this protein?
[Interleukin-16]: Secreted. SUBCELLULAR LOCATION: [Pro-interleukin-16]: Cytoplasm. Nucleus.
Protein: MUTL_CAUVN
Sequence: MPIRRLPPETVNRIAAGEVVERPASAIKELVDNAIDAGATRIEVEAHGGGLTRILVADDGCGLSPEELPVAIERHATSKLAPDADGLWDLLRIHTMGFRGEALPSIGSVARLQISSRAKGAKDAFSILVEGGQVGEVAPAAFPGPHGARIEVRDLFYATPARLKFMKSERAEALAITEEIKRQAMANESVGFSLDIDGRRVLRLPPEHPGPQGRLARLAAVLGREFQENALEIDQTRDGVRLSGFAGLPTYNRGNAAHQYLFVNGRPVRDRLLQGALRAAYADFLARDRHPTAALYVTLETTEVDVNVHPAKAEVRFRDPALVRGLIVGALRHALAGAGHRASTTVAAQALDSIRAQQSPFPGYQPQYQPGPSPAGFSAWREGGWTPPTQRPMDLPGLNEVSARVEPSYGGDLAGVVREAYAAAAFEDRPPTDYPGATAPFDPVDYPLGAARAQVHETYIVAQTRDGMVIVDQHAAHERLVYERMKGEMASGGVTRQTLLLPEVVDLDPAEAERVVARAEELAGLGLVLESFGPGAVLVRETPALLGKTDAAALVRDIADDLAENGQALALKERLEEVCSTMACHGSVRAGRRLNGAEMNALLREMEATPHSGQCNHGRPTYVELKLADIEKLFGRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: DCUP_PSEU2
Sequence: MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRASAGDFMSLCKNPQFACEVTLQPLDRYPLDAAILFSDILTIPDAMGQGLYFETGEGPRFRKTVSTLADIEALPIPDAQQDLGYVMDAVSTIRRELNGRVPLIGFAGSPWTLATYMVEGGSSKDFRKSKAMLYDNPQAMHLLLDKLAQSVTSYLNGQILAGAQAVQIFDSWGGSLSSAAYQEFSLAYMRKIVSGLIRENDGRKVPVIVFTKGGGLWLESIADIGADTLGLDWTCDIGEARQRVGSKVSLQGNMDPTVLYARPEAIRQEVARILASYGSGTGHVFNLGHGITPEVDPANAGAFINAVHELSAQYHV
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDE2_MOUSE
Sequence: MALFPAFADVSEASGDGAFRKELDWLSNPSFRVGNLTSLSRQTEEVTALASEGSPPPRYSFIRSPLKSELSGESNTSEKLAQTSRKKKKEKKKRRKHQHHRKTKRRHEQLSSSGSESDTEAGKDRASRSIRDDQKEAEKPCQGSNAAAAVAAAAGHRSIWLEDIHDLTDVFRTDKKPDPANWEYKSLYRGDIARYKRKGDSCLGINPKKQCISWEGASAAKKHSHRHLERYFTKKNVGLMRTEGIAVCSNPEPASSEPVTFIPVKDSAEAATPVTSWLNPLGIYDQSTTQWLQGQGPAEQESKQPDSQQDRENAALKARVEEFNRRVRENPWDTQLWMAFVAFQDEVMRSPGIYALGEGEQEKHRKSLKLLLEKKLAVLERAIESNPGSVELKLAKLQLCSEFWEPSALAKEWQKLLFLHPNNTSLWQRYLSFCQSQFGTFSVSKLHSLYGKCLSTLSAVKDGSMLSHPVLPGTEEAMFGLFLQQCHFLRQAGHSEKVISLFQAMVDFTFFKPDSVKELPTKVQVEFFEPFWDSGEPRVGEKGARGWRAWMHQQERGGWVLITPDEDDEEPEEEDQEIKDKTLPRWQIWLAVERSRDQRHWRPWRPDKTKKQTEEDCEDPERQVLFDDIGQSLIRLSSPDLQFQLIQAFLQFLGVPSGFLPPASCLYLAMDESSIFESELYDEKPLTYFNPSFSGISCVGSMEQLGRPRWTKGHNREGEEFVRNVFHLVLPLLAGKQKSQLSLSWLRYEIAKVIWCLHTKKKRLKSQGKSCKKLAKNLLKEPENRNNFCLWKQYAHLEWLLGNTEDARKVFDTALSMAGSSELKDRELCELSLLYAELEMELSPDSRGATTGRAVHILTRLTESSPYGPYTGQVSSTQVLKARKAYELALQDCLGQSCASSPAPAEALDCLGSLVRCFMLFQYLTVGIDAAVQIYGRVFAKLKGSARLEDPGPEDSTSSQSLTNVLEAVSMMHTSLLRFHMNVCVYPLAPLRETLSDALKLYPGNQVLWRAYVQIQNKSHSANKTRRFFDTVTRSAKHLEPWLFAIEAEKLRKKLVESVQRVGGREVHATIPETGLTHRIRALFENAIRSDKGNQCPLLWRMYLNFLVSLGNKERSKGVFYKALQSCPWAKVLYMDAMEYFPDELQEILDVMTEKELRVRLPLEELELLLED
What is the function of this protein?
Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation.  Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation.  Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome.  By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (By similarity).  U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (By similarity).  Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (By similarity).  Plays a role in DNA damage response (By similarity).
What are the official names of this protein?
Nuclear exosome regulator NRDE2, Protein NRDE2 homolog.
What is the protein family that this protein belongs to?
Belongs to the NRDE2 family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.
Protein: BGAL2_LACAI
Sequence: MTQLSRFLYGGDYNPDQWPEETWSKDIHVFKKADINSATINIFSWALLEPREGKYNFSKLDKVVQQLSDANFDIVMGTATAAMPAWMFKKYPDIARVDYQDRRHVFGQRHNFCPNSSNYQRLAGELEKQLVERYKDNKHIVFWHINNEYGGNCYCENCQNAFKKWLKNKYKTVEGLNKAWNMNVWSHTIYDWDEIVVPNELGDVWGIKGSETIVAGLSIDYLRFQSESMQNLFKMEKKIIKKFDPETPVTTNFHGLPNKMVDYQKWAKGQDIISYDSYPTYDAPAYKAAFLYDLMRSLKHQPFMLMESAPSQVNWQPYSPLKRPGQMEATEFQAVAHGADTVQFFRLKQAVGGSEKFHSAVIAHSQRTVTRVFKELADLGKKLKNAGPTILGSKTKARFAIVFDWSNFWSYEYVDGITQDLNYVDSILDYYRQFYERNIPTDIIGVDDDFSNYDLVVAPVLYMVKHGLDKKINDYVENGGNFVTTYMSGMVNSSDNVYLGGYPGPLKEVTGIWVEESDAVVPGQKIKVLMNGKDYDTGLICNLIHPNDAKILATYASEFYAGTPAVTENQYGKGRAWYIGTRLEHQGLTQLFNHIIFETGVESLVCDSHKLEITKRVTEDGKELYFVLNMSNEERTLPSKFTGYEDILTGEKAHKDMKGWDVQVLRN
What is the function of this protein?
Hydrolyzes lactose, oNP-galactoside (oNPG), pNP-galactosidase (pNPG), pNP-mannoside, pNP-glucoside, pNP-fucoside, pNP-N-acetylglucosamide, but not pNP-arabinoside or 4-methylumbelliferyl-beta-galactopyranoside (MUG).  Transgalactosylates lactose at 10 g/L, but not at 270 g/L.
What are the official names of this protein?
Beta-galactosidase LacA, Beta-gal.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 42 family.
Protein: GLMU_SYNP2
Sequence: MVAVAILAAGKGTRMKSDLPKVLHPLGGRSLVERVIESCALIKPERICTIVGYRAAEVKMALAHLPHLEFVEQTEQLGTGHAVQQLLEPLKDFVGDVVILNGDVPLLRPETIADLVSTHQKNNNDATLLTAQLPNPTGYGRVFCDGDNLVTQIVEHRDCNDAQRKNNRINAGVYCFKWGVLAEALPKLTTNNDQQEYYLTDVILHCDKVMAMDVADFQEISGINDRFQLSAAYEILQDRIKEKWMKAGVMIHQPDTVTIDDTVQLEPDVMIEPQTHLRGNSLIKTGCRLGPGSLIENSVIEANTTILYSVVSDSQVGENAQIGPYTHIRGQAKVGEQCRIGNFVEVKKSTIGNNTNMAHLSYIGDATLGAKVNIGAGTITANYDGVNKHQTVIGDRSKTGANSVLVAPITIGEDVTIAAGSTITKDVDNDCLVVARARQKEIKGWRLQS
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF3A_USTMA
Sequence: MPPFAKPETVLKRSEELINVGQHQAALAALNEIFTSRRFKQTPLQSLEPIMLRFVDLCVDLKKGRMAKEGLMQYKNVSQNTNAQSIELVIKHFIKLADAKVVEAQSKADAAVGEIDVDDLEESETPESMLLGSVSADQNKDRTDRVLVTPWLKFLWEAYRTALDILRNNARLEVPYQQIANQALKFCLQYQRKTEFRRLCEVLRQHLQNVARYSHHAHAINLTDQDTLQRHLDTRFAQLNSAVELELWQEAFRSVEDIHNLLTMAKKAPRPAMMANYYEKLARIFMVSDNNLFHAAAWNRYYALARSIAKSEQEHTQIASYVLISALAVPVISSNAPGTGNLHKSKSDFLQADHEARSRTGRLTSLLGLSRTPTRAGLLKEALNRDILKKARPELRELYNILEVEFHPLSICAKIEPILASISQDAEMAKYVKPLHSVVLTRLFQQLSQVYDAVKLSKVMQLVSAFKAPHSYTPAEIEKFCLNACKKGHLNIRIDHVAQAITFQDDVFSTDVHPAASASSEADNVGLQASPSELVRTQLSRLATCLDTTLKTIDPTILADAQAAKRHVFARAVAAAEDEHKAAIARKALLARRKELLEEMATRKEREEAAARAERARAAAEAEQKRIAEEQKKREQDRLNKEVEAVRIEEAKKMAKSLQERGGLKLSEEELANLDTDKLVQMQVEQIEKEKKELAERLRLIHRRMDHLERAYRREEAPLLSADYERQKQEDLQYHKAARITLLQTSKDKHAADLEIKKRLTRILPDYQQLRSIIEDKRRGEFEERRRKATEQIELEKERRRQQVRDERRRERQEAEEAERRRVQEEQEARARAEEEERLAEQRRVEEAQRAELEAKKRAEIEERRAKFQATADKQRQREEEAEANRRSRAAGTGAAPAQELAAADATWRRASGSPAPTQAESQRPPIFGAARTGGAGGWRERLAAKEAAGGNATAAPSAPAAAPAPASSGAYRPGMFRAAAGAGAGGRTDRVAATPLPPAAAAAESDGFTEVKKNVYRPPGRRA
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit A, eIF3a, Eukaryotic translation initiation factor 3 110 kDa subunit homolog, eIF3 p110, Translation initiation factor eIF3, p110 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSB1_YEAST
Sequence: MSASLVNRSLKNIRNELEFLKESNVISGDIFELINSKLPEKWDGNQRSPQNADTEEYVEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGKSNNKIGIFPANYVKPAFTRSASPKSAEAASSSTVSRPSVPPPSYEPAASQYPSQQVSAPYAPPAGYMQAPPPQQQQAPLPYPPPFTNYYQQPQQQYAPPSQQAPVEAQPQQSSGASSAFKSFGSKLGNAAIFGAGSAIGSDIVNSIF
What is the function of this protein?
Involved in resistance to EDTA.
What are the official names of this protein?
LAS seventeen-binding protein 1, LAS17-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the LSB1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, actin patch.