PharMolix/UniProtQA huggingface dataset:
Protein: ARAP3_MOUSE
Sequence: MAAPQDLDIAVWLALVHLEQYADTFRRHGLATAGAAQHLGHEELRHLGISATGHRKRILRLLRAGSAEGFLDSHLDNTMEPTPSPAPDAQPPKPVPKPRTVFGLSNPATAQRPGLSPIFWDPEVSRNSECTQRSSPLLPSSSEQPSVPNTMEMMPNAIYFGLDLRGRAQAAQDVTPDSSQATVPTPAFRPTTGTVHIMDPGCLYYGVQPVGIPGASDRRDGRGVCQERAEHRQDLETREDAGYASLELPGDSILSLPTQDAETSDDLISPYASFSSTADRPVPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDLWCSTLQSCLKEQRLLGHPRPPHPPRPLRTGTLELRGHKAKVFAALIPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKVWSNPANRHCADCRASRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANCFWAGALPPGEGLHPDSAPGPRGEFISRKYKLGLFRKPHPRHPDHSQLLQALCAAMAGPNLLKNMAQLLCVETSEGEEPLSPSALNGSLLSLLPSDSPGVYNEVVVPATYRGFLYCGSISNKAGAPPLRRGRDAPPRLWCVLGAALEMFASESSPEPLSLLQPQDIVCLGVSPPPADPGDLDRFPFSFELILTGGRIQHFATDGADSLEAWISAVGKWFSPLSCHQLLGPGLLRMGRLWLRSPSHAGLAPGLWLSGFGLLRGDHLFLCPAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFAAWNTAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPREHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELSQKNQRLEKYKEVISCLPRVNRRTLATLIGHLYRVQKCASLNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDSDQAAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEELTNQVLEMRGAASGTDLWVTFEILEHGELERPLHPKEKVLEQALQWCQLPEPCSASLLLRKVSMAHAGCLFTGVRRESPRVGLLRCREEPPRLLGNRFQERFFLVRGRCLLLLKEKKSSKPEREWSLEGAKVYLGIRKKLKPPTLWGFTLILEKMHLCLSCMDEEEMWDWTTSILKAQHDDQQSVVLRRRSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLSMFFPMKSPQGSVEEQDELEEPVYEEPVYEEVGAFPELTKDTTFSSTWEWSAKSDPSLTSQRSFDQPPLSKASMLGHEERIPDPPPGPPSKSSSQARGSLEEQLLQELNNLILRKGEPASCPESSSQPTSPQAPSPTSLPTPTPSLPTQPPCTSNPPSSQPLT
What is the function of this protein?
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members.  Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding.  Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency.  Acts preferentially on ARF5 and on RHOA.
What are the official names of this protein?
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, Centaurin-delta-3, Cnt-d3, Dual specificity Rho- and Arf-GTPase-activating protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Note=Cytoplasmic, and associated with F- actin-rich membrane ruffles and lamellipodia.
Protein: RUBIC_MOUSE
Sequence: MRPEGAGMDLGGGDGERLLEKSRREHWQLLGNLKTTVEGLVSANCPNVWSKYGGLERLCRDMQNILYHGLIHDQVCCRQADYWQFVKDIRWLSPHSALHVEKFISLHESDQSDTDSVSERAVAELWLQHSLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKQESPLLVTKSQSLTALPGSTYTPPASYAQHSYFGSSSSLQSMPQSSHSSERRSTSFSLSGPSWQPQEDRECLSPAETQTTPAPLPSDSTLAQDSPLTAQEMSDSTLTSPLEASWVSSQNDSPSDVSEGPEYLAIGNPAPHGRTASCESHSSNGESSSSHLFSSSSSQKLESAASSLGDQEEGRQSQAGSVLRRSSFSEGQTAPVASGTKKSHIRSHSDTNIASRGAAGGPRNITIIVEDPIAEGGQYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPAYRETENGSFRVTSSSSQFSSRDSTQLSESGSAEDADDLEIQDADIRRSAVSNGKSSFSQNLSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMVVPSRILRKWDFSKYYVSNFSKDLLLKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLYHMKNMFKTCRLAKELLDSFDVVPGHLTEDLHLYSLSDLTATKKGELGPRLAELTRAGAAHVERCMLCQAKGFICEFCQNEEDVIFPFELHKCRTCEECKACYHKTCFKSGRCPRCERLQARRELLAKQSLESYLSDYEEEPTEALALEATVLETT
What is the function of this protein?
Involved in regulation of pathogen-specific host defense of activated macrophages.  Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways.  Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines.  Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (By similarity).
What are the official names of this protein?
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, Rubicon.
What are the subcellular locations of this protein?
Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
Protein: RPOA_NYMAL
Sequence: MVREEVPVSTRTLQWKCVESRADSKRLYYGRFVLSPLMKGQADTIGIAMRRALLGELEGTCITRAKSDKVPHEYSTVVGIEESVHEILMNLKKMVFRSDLYGTLDASICVRGPRHVTAQDIISPPSVEIVDTTQHIAVLTEPVDLCIELKIERGRGYCTRTQNNYQDGSYPIDAVSMPVRNANHSIHSYGNGNEKQEILFLEIWTNGSLTPKEALYEASRNLIDLFIPFLHAEEQDINRNMEDNLKRASVPFFAFDDGLDNIKREIILKRIFIDQLELPPRTYNCLKRSNIHTLLDLLSKSQEDLMRIEHFRVEDVKQIFDILQKGFTIDLLKNSNQFESR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PAND_SALHS
Sequence: MIRTMLQGKLHRVKVTQADLHYEGSCAIDQDFLDASGILENEAIDIWNVTNGKRFSTYAIAAERGSRIISVNGAAAHCAEVGDIVIIASFVTMSDEEARTWRPKVAYFEGDNEMKRTAKAIPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP1_PANTR
Sequence: MARYRCCRSQSRSRCYRQRQRSRRRKRQSCQTQRRAMRCCRRRSRMRRRRH
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1, Cysteine-rich protamine.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: METE_STRAW
Sequence: MTAKSAAAAARATVYGYPRQGRGRELKKAIEGYWKGRLDADALRTTATGLRRDTWQQLAEAGIHEVPTGDFSYYDHVLDTSVMVGAIPARHRAAVEADALDGYFAMARGTQDVAPLEMTKWFDTNYHYLVPELGPDTVFSTDSAKQVAELGEALALGLTARPVLVGPVTYLLLAKPAPGVAADFDPLTLLDRLLPVYAEVLADLRAAGAEWVQLDEPALVQDRTPAELNAAERAYRVLGGLTDRPKLLVASYFDRLGDALPVLAEAPVEGLALDFAEGAAANLDALAAVGGLPGKRLVAGVVDGRNIWVNDLEKSLALLGTLLGLADRVDVAASCSLLHVPLDAAAERDIAPQVLRWLAFARQKTAEIVTLAKGLGHGTDAIAAQLAANRADLVSRADSALTRDPAVRSRTAATTDADARRSGPYPERAAAQRARLGLPLLPTTTIGSFPQTAELRTARADLRAGRIDSAGYEERIRAEIGEVISFQEKAGLDVLVHGEAERNDMVQYFAERLTGYLTTQHGWVQSYGTRYVRPPVLAGDISRPEPMTVPWTTYAQSLTDRPVKGMLTGPVTMLAWSFVRDDQPLGETARQVALALRDEVGDLEAAGTSVIQVDEPALRETLPLRAADRPAYLAWATEAFRLTTGGVRPDTQIHTHMCYAEFGDIVQAIDDLDADVISLEAARSHMQVARELAEHAYPREAGPGVYDIHSPRVPGVDETAALLRKGLEAIPAERLWVNPDCGLKTRGWPETRASLENLVAAARTVRAEHAGS
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: MURD_COLP3
Sequence: MTWLTAFKDKNIVVLGAGMTGLSCLRFLHAQDLSFAVNDSRPMPFANRDEQTQYENDYPKAKFVFGQWQQSLISSADIIITSPGIDLVSEGITALIPENCLVIGDVELFCLVNNSRISPMKMLAVTGSNGKSTVVSLLASLAKAIGVNAALAGNIGEPILNLLHRENVYNSQLANQPDIVIVELSSFQLETLSSMHAIAASVLNLSDDHLDRHKTLANYQAIKQSIYPQAKIAVVSREDQASNTLVAAQEIISFGLNKPEQDCFGLQAIDNKMVMMFGEQALISIDELPLAGMHNALNYMAALALGYSAGWSLSAMTENLAGFMGLAHRCQRVASEDYIQWINDSKATNVGATLAAITGLVPTLTGQNKLILIAGGDGKGADFSALTTILNCDVNQLITLGKDGAEIASLVSDAIQVDTLREAVEQAKQIAKPGDMVLLSPACASIDMFKNYQVRGEQFIAAVQAKEDSCR
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM238_HUMAN
Sequence: MAAAPAVCASQGSPPGAPSAPAAAPAPAAGLGRCRMALLLAVALDVAGMAALLTGVFAQLQVRGRDFGDLLIYSGALLVFLSLLGWILWYTGNIEISRQELERDYGLRPSALARLARKLSRRWSAPAAAGQRPAPGSRRARRAARAPPPPAAGSRRVRLQLATLEAGPGAAGAGSE
What are the official names of this protein?
Transmembrane protein 238.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RET2_PIG
Sequence: MTRDQNGTWEMESNDNFEGYMKALDIDFATRKIAVALTQTKIIEQDGDKFKTKTNSTFRNYDLDFTVGVEFDEYTKGLDNRNVKTLIIWEGDALVCVQKGEKENRGWKQWVEGDKLYLELTCGDQVCRQVFKKK
What is the function of this protein?
Intracellular transport of retinol.
What are the official names of this protein?
Retinol-binding protein 2, Cellular retinol-binding protein II, CRBP-II.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_RICAH
Sequence: MPRRVLQGVVISSKADKTVTVKVERKFKHPIYKKFVKVSKKYAAHDSENKYQEGDKVSIIESRPISKTKTWIVVNGE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RNH_CAUVC
Sequence: MTPKVTIYTDGACKGNPGPGGWGAILFYGDKKKEICGGEPGTTNNRMELMAAIQALELLNRPCVVELHTDSQYVMKGIQEWIRGWKARGWKTADKSPVKNDDLWKRLDAARARHDVDWRWVKGHAGHPLNERADALANEGLRQANPRVI
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HI, RNase HI.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTCA_DROME
Sequence: MDAEKMLEIDGSYLEGGGQALRNALSLSCILGKPVRVVKIRASRPSPGLSHQHLHGLNLLRDITNADVVGNYLLSSTVEFTPRTILDNTYRVETHTAASITLIYQMALPVLLFAGRPSRLIVSGGTNVDFAPPVEYMQEVLLPNLKHFGVSFDLKVQRYGFYPRGQGRCQLDVQPVTKLNSGKLVAFGRIKSVSGVAYCAGRLPVNIAIDMQQTAQREIHRLWPSQQCSIEPIKHSRQKAFHNGAGILMTVNTTSDVVLGASALGKKRIDGHVLGSEASCQLGDYMRKQVCVDDYMQDQLIIYMALAVGRSTMRTGKLTNHTRTAINVAEQMTGVKFDVAMEPGGQMLVSCKGLGHVNKLI
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: HAT1_EMENI
Sequence: MSAEGEWSCDANDAVQITIVHPDQQKPKTLSSFHPQFTYPIFGEEERIFGYKGLIIRLRFAAHNLRPHVHVSYDEKFTAVDDAEPVDIIGALKEFLPEEAFSSLPEFESAVQEEDAKEFVPPGKLSHSYSIRGRNYEIWAASLADPQVQLLLNRFQIMVSFYIEAGTPLSTDDPEWTLDRWTVYFVLTAARYEKVEPPTPTASSYSIVGYATTYRWWFYKRDRSENPMPRDGPFPPPELVRPGELPSRLRIAQFLILPPHQGTGHGVNLYNTIHKTCLDDPTIMELTVEDPNESFDVLRDSADYHILRPEFLKHNIQINPDPWSDFSKKTKRVPTSSLLPLKTLNEIRTAYKIEPTQFAHIQEMFLLGQIPLKNRRKGGANMARLLVKKYRDDDPNNRRYYWWRMLTKQRLYKRSRDVLIQLKMSERHKALEDTVTNVEDGYEQLFGFFNEREERLRAQQEEAETSNNRDQRTKRKFTVEDEDDEDESAAAKRPKA
What is the function of this protein?
Catalytic component of the histone acetylase B (HAT-B) complex.  Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing.  Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.  Involved in DNA double-strand break repair (By similarity).
What are the official names of this protein?
Histone acetyltransferase type B catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the HAT1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: K6TX1_ACTBE
Sequence: RCKTCSKGRCRPKPNCG
What is the function of this protein?
Potassium channel inhibitor that is the most potent on Kv1. 1/KCNA1 (IC(50)=671. 95 nM), Kv1. 2/KCNA2 (IC(50)=167. 36 nM), and Kv1. 6/KCNA6 (IC(50)=115. 68 nM), and less potent on Kv1. 3/KCNA3 (20% inhibition at 3 uM) and on shaker IR (15% inhibition at 3 uM).  It inhibits potassium currents, not only by blocking the potassium current of Kv1. 2/KCNA2, but by altering the energetics of activation of Kv1. 1/KCNA1 and Kv1. 6/KCNA6.
What are the official names of this protein?
Potassium channel toxin AbeTx1.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 6 potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: FABH_CALS8
Sequence: MAQNVKILSTGRYVPDRVLTNYDLEKMVDTSDEWITQRTGIKERRIVDGTTSTTDLAVRAAKNAMDKAGILPDDIDLVIVATVTPEMFFPSTACLVQKELKLKNAFAFDISAACSGFIYAMAIATHFIQNGFCKNALVIGAEALSRITNWSDRSTCVLFGDGAGAAILSSSDEQGILGFELGSDGENGLLLYCHAFGLSDVTYSQVKENPNFRKIYMEGNEVYKFAVKIMPYAVEKVLEKVGLSSSDIDVFIPHQANIRIIESAAKRLKIPMEKVFVNLHKYGNTSAASIPIALDEAVEEGRIKKGDKVVLVGFGGGLTWASTVIKWV
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGS_CANGA
Sequence: MWAHLFKHGFKYEQQNSLSKSLILSVLNSTATKREAKDYLIKYANGSSNYHYLLLIRNIATQSERSLHRLSDSIRRLKFLGISPVCVLLPSGRIQTEVEKMDKLITLSQLKPLVLDYGLSRAFDGSYESIMQTALDTEYCTTRGIVPIVKPYIYDQSTASRGLISDPVLFMDQLSRDSSLKFDKFFILNRSGGIPSGERNQNSHIFINLSQEYQKIHRTLTSSIRTIVERQPRSEDLLDRLELYVRESDIISLEAEYKEHMENLQLMNTVLSNLSSSATGVITTINAASSPSDTVNPLVHNLLTDRSIISSSLPRFKNKSGNFLSPSGQDWYEMPVEIETDEETLQGEDSVFVTTVLKKGVDIKEFDYSHLTSENTVNLPKQFQIKLHDESTYNNSCSKYKLDLVKFKNIIDKSFGRELDLNHYLNRINGKIASIIIIGDYEGIAILTYEGPPDNKFVYLDKFAVLPHLKGSLGISDIIFNLMFKKFPREVVWRSRANNVVNKWYFQRSVAVLDLSMELDEGDMQESEFKLFYHGDPESSLKSIVAIDRLRDLAKYVRNIKPSWVK
What is the function of this protein?
N-acetylglutamate synthase involved in arginine biosynthesis.
What are the official names of this protein?
Amino-acid acetyltransferase, mitochondrial, Arginine-requiring protein 2, Glutamate N-acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UVRB_NITOC
Sequence: MKDIFQLVSDYQPAGDQPEAIERLTEGLAAGEMYQTLLGVTGSGKTFTIANMIQQVQRPTIVLAPNKTLAAQLYSEMREFFPRNAVGYFVSYYDYYQPEAYVPASDTYIGKDASVNDHIEQMRLSATKAFLERPDAIVVASVSAIYGLGDKDSYLNMVLHLMVGDTVDHRGILRRLAELQYQRNDRELYRGTYRVRGEIIDIYPAESEQEAIRVELFDDEIESLSYFDPLTGEILHRVSRLTIYPKTHYVTPREVLLQAVDEIKIELAERLEQLYGANKLVEAQRLEQRTRFDIEMILELGYCTGIENYSRFLSRRQPGEAPPTLFDYLPKNALLVIDESHVTVPQLGAMYRGDRARKETLVEYGFRLPSALDNRPLKFEEWEQLAPQTIFVSATPGPYEQQHSGAVIEQVVRPTGLVDPAVEVRPAGSQVDDLLSEIRQRTAADERVLVTVLTKRMAEDLTQYLEQHEVRVRYLHSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLHGRAILYGDKVTGSMGRAIAETERRRKKQLAFNETHRIIPRGIQKAVREIIDGVYTPGSGKGHRSPDRVEEKAAEYTRLPPQQLAKRLQQLERQMHKHAQNLEFEQAARLRDEIKRIKGWVFNGADSASAPRQENSQARAIC
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_BURCH
Sequence: MKTTFLDFEQPIAELEAKIEELRFVQDDSAVDISEEIERLSKKSQQLTKDLYANLSPWQVSQIARHPQRPYTLDYVAELFTDFHELHGDRAFADDLSIVGGLARFGGHPCMVIGHQKGRDTKERAARNFGMPRPEGYRKAERLMRLAEKFGLPIFTFVDTPGAYPGIGAEERGQSEAIGRNLYVMAELKTPIITTVIGEGGSGGALAIAVADTVMMLQFSTYSVISPEGCASILWKSAAKAPEAAEALGLTAHRLKALGLIDKIINEPLGGAHRDPKGMAALLRRALADSLRQFQGMSIDALRERRFERLMAYGKFKETTPGA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M1_I83A6
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEVLMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEVALSYSTGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVHAMRTIGTHPSSSAGLRDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: FAU1_PYRNV
Sequence: MFRARIRGIYATALTKLALDWGFKVVQPTPQIAERFGLRPDPSPPDVTVKDHESKTGVVAIGDCPAVDHLLERLREYADPVVAKASAGLHDVFVGRVVGEGLVEGPGGLMEVPGRYVLQPGAASVFTVVKPPVGPLRGVAVPEIVVDGKLLELNTTGRVAYSRHIGEEERLRLRILAETRLKAYASIGLRFKSSAKYAGEEELAREAEELYRELLRLSQGGPPGALLRRGRCLAVVLFDKRAKFKLDEARAAVVPTVRGHHALRGQGLGRCLDLLDHVGADVYERAAAFLARGRVAIYHVKPWGEVVKMRGEVVKALEDVLVVKRTLKPGGVLDGIGARIEPGTYALTCVPRSGGYVVHSYYSASGVYLGTYVNANTEPEWGRRVVYIDLLVDKAYGPDGVERVLDEEELQRYAHMLPERLRRPEAPGGKICTPEGLTSAPPRSSSA
What is the function of this protein?
Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs.  Binds to RNA in loop regions with AU-rich sequences.
What are the official names of this protein?
Probable ribonuclease FAU-1, RNA-binding protein FAU-1.
What is the protein family that this protein belongs to?
Belongs to the FAU-1 family.
Protein: DAGK_STAAM
Sequence: MRKRARIIYNPTSGKELFKRELPDALIKLEKAGYETSAYATEKIGDATLEAERAMHENYDVLIAAGGDGTLNEVVNGIAEKPNRPKLGVIPMGTVNDFGRALHIPNDIMGALDVIIEGHSTKVDIGKMNNRYFINLAAGGQLTQVSYETPSKLKSIVGPFAYYIKGFEMLPQMKAVDLRIEYDGNVFQGEALLFFLGLTNSMAGFEKLVPDAKLDDGYFTLIIVEKSNLAELGHIMTLASRGEHTKHPKVIYEKAKAINISSFTDLQLNVDGEYGGKLPANFLNLERHIDVFAPNDIVNEELINNDHVDDNLIEE
What is the function of this protein?
Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid.  Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway.
What are the official names of this protein?
Diacylglycerol kinase, DAG kinase, DAGK.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family.
Protein: YTOQ_BACSU
Sequence: MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDNIGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAIAKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE
What are the official names of this protein?
Uncharacterized protein YtoQ.
Protein: CBLN2_MOUSE
Sequence: MPAPGQGPRGPLLSMPGRRGALREPADFGSSLGAVLALLLLLLPACCPVRAQNDTEPIVLEGKCLVVCDSSPSGDGAVTSSLGISVRSGSAKVAFSATRSTNHEPSEMSNRTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQVSLMQNGYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLERGNLMGGWKYSTFSGFLVFPL
What is the function of this protein?
Acts as a synaptic organizer in specific subsets of neurons in the brain (PubMed:29691328, PubMed:21410790).  Essential for long-term maintenance but not establishment of excitatory synapses (PubMed:29691328, PubMed:30287486).
What are the official names of this protein?
Cerebellin-2.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMM_PSEPW
Sequence: MNTLFMHCRPGFEGEVCAEISEHAARLGVAGYAKGKPQSACAEFVCAEAEGAERLMAQLRFAQLIFPRQWARGSYIELPETDRISVLLEHLAALPVFGSLWLEVLDSNDGKELSTFCRKFEVPLRKALEKAGRLVDNASLPRLLLTFISGRRVFVGVAEANNSALWPMGIPRLKFPREAPSRSTLKLEEAWHQFIPREQWEQRLGDDMTGVDLGASPGGWTYQLVRRGMLVTAIDNGPMAESLMDTGLVQHLMADGFTWQPKQPVDWMVCDIVEKPARTTSLIETWLGEGLCREAVVNLKLPMKQRYAEVRRLLDRMEATFKARKLKVSIACKQLYHDREEVTCHLRRLDLKPRK
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_DECAR
Sequence: MTRKALAAGLADLGIDLPDEAQQKLLAFRDLLLKWNKTYNLTALRDPAQAISHHLLDSLAILPHVGSGNLLDVGSGGGLPGIPLAIARPELSVSMVDTVQKKTTFLQQAVIELALRNVTVHHARVEEMQGQYAQISSRAFAEIGLFISLTRHLLAPNGRWLAMKGVRPDDELKALPADIAVEAIIPLTVPGLDAERHLIILKAGS
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.