PharMolix/UniProtQA huggingface dataset:
Protein: ACLI_ASPOR
Sequence: MASAGAGLSKRGASNVDAIMPGIRAALLERTRPTVPRIDLSTAENWLLRNEVIELTKDAIRDGLKPHHLSYPNEFAGDADLIKALAAFVNEYFHPHIPVEPDHIATAPGAATCLNTFLYNLCEPGEGILVPAPFWNGFDWLFTARSSAVPVMVHVERSADTLTAKLIPALEKAYEESKIPIRGLLLTNPQNPYGQCYPRSVMEDCIRFCHSKGIHYISDEVYALSNFENPELPDAPPFVSALQIDVKGIGCDLSRVHTFWSTSKDFGSSGFRVGCSITQANEAMHVALALASNTESSSLSAVASTALLTSPRLPELLQLNAQRLQEAYCLMTNFLKKHQIEYIPANSAPFLFARVAPQAQTWEDEKAVIAQLKEAGVNVSGGKAYHVNEDQKGWARLTFALETSRAEEAIKRMETVLGKQ
What is the function of this protein?
Probable aminotransferase; part of the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells (PubMed:25302411).  The non-ribosomal peptide synthetase (NRPS) aclP is responsible the formation of the diketopiperazine (DKP) core from the condensation of 2 phenylalanine residues (PubMed:25302411).  One Phe residue is tailored into chlorotyrosine by hydroxylation and chlorination, whereas the second Phe undergoes an unprecedented C-C bond cleavage to be converted into glycine (PubMed:25302411).  After formation of the DKP, sulfur is incorporated into the DKP by conjugation with glutathione by aclG, followed by its stepwise degradation to the thiol by aclI, aclJ and aclK, and the dithiol oxidation by aclT (PubMed:25302411).  In addition, oxygenases (aclB, aclC, aclL and aclO) and O-methyltransferases (aclM and aclU) act as tailoring enzymes to produce the intermediate dechloroaspirochlorine (PubMed:25302411).  Ultimately, chlorination of dechloroaspirochlorine by the halogenase aclH is the last step in the aspirochlorine pathway (PubMed:25302411).
What are the official names of this protein?
Probable aminotransferase aclI, Aspirochlorine biosynthesis protein I.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: Y598_STRPJ
Sequence: MNETQIQRETRQVVEDVLEKTNLKQGALFVLGLSSSEVLGGHIGKESSQEIGELIVETILDILGSRGIHLAVQGCEHVNRALVVERQVAEQFGLEIVSVHPTLHAGGSGQLAAFKFMQDPVEVEFIKAHAGLDIGDTAIGMHVKHVQVPIRPILREIGHAHVTALASRPKLIGGARAHYPQDAIRKT
What are the official names of this protein?
UPF0340 protein SPN23F05980.
What is the protein family that this protein belongs to?
Belongs to the UPF0340 family.
Protein: I7_FOWPN
Sequence: MDKYTELVINKIPELGFVNLLSHIYQTVGLCSSIDISKFKTNCNGYVVERFDKSETAGKVSCVPISILMELVERGMLSKPDNSKSQLEVKTDLVNELISKNNGFEDIMTIPTSIPMKYFFKPVLKEKVSKAIDFSVMDIKGDDVSRMGIRYGENDKVVKIKIAPERDAWMTNTSIHQFLIPMCYGTEVIYIGQFNFNFMNRHAIYEKSSVFNKNTEVFKLKDRIRDNRSSRFIMFGFCYLHHWKCAIYDKNRDFICFYDSGGNNPNEFNHYRNFFFYSNSDGLNRNSYLSSLANENADIDILFNFFIDNYGVTAGCINVEVNQLLESECGMFTCLFMAVCCLNPPKGFKGIRKIYTYFKFLADKKVTMLKSILFNVGKMEFTIKEVDGEGMQQYKKMEKWCANTINILANKITSRVEDIIN
What is the function of this protein?
Late protein responsible for processing most or all of the viral core and membrane proteins known to undergo morphogenesis-associated proteolysis.  These proteolytic events are involved in the transformation of immature virions (IV) into mature virions (MV) (By similarity).
What are the official names of this protein?
Core protease I7 homolog, Protein FPV083.
What is the protein family that this protein belongs to?
Belongs to the peptidase C57 family.
What are the subcellular locations of this protein?
Virion. Note=Present in the virion core.
Protein: YWHC_BACSU
Sequence: MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKKQGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLILAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRIIEDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPLL
What are the official names of this protein?
Putative zinc metalloprotease YwhC.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GEK1_ARATH
Sequence: MVTLIVATTADPASINPAAALLAMPGWTAGPILPPDIKSFSNKQTRVIQHDRSIVKEDDLDLRWEEATGEVVDEVIFLSRHTAVSNRPALTVHPIGVLHLKDGESPPQGGKPGWAALPSTRIGPWFRLLKKMAEAHGLVPEFEITLEATHHGPITNKPTMFLEIGSTEEYWKRQDAAQVMALLMWEGLGLGGSEEVGKWKSETGKRKVLLGIGGGHYAPRHMDIALKDDIWVGHLLSGYSLPMEDPTQTKTTPGENYIGGNWRQSIKAAFEATKASFPGGEILAHLDHKSFKGWQKKAITEFLAEESINVGKPNDFT
What is the function of this protein?
Hydrolyzes D-aminoacyl-tRNA into D-amino acid and free tRNA.  Broad specificity toward the amino acid, but strict specificity toward the D-isomer.  Seems to be required for ethanol tolerance.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, Ethanol tolerance protein GEKO1.
What is the protein family that this protein belongs to?
Belongs to the DtdA deacylase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: TYSY_SHEPW
Sequence: MKQYLELCQRIIDEGTWVENSRTGKRCLTVINADLVYHVDKNEFPLITTRKSFWKAAIAEMLGYIRGYDNAADFRNIGAKTWDANANDNQAWLNNPHRKGADDMGRVYGVQGRGWSKPDGGSIDQLRKIVDNLSKGIDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLLGDTLHLTSFQRSCDVPLGLNFNQVQVFTLLALIAQITGHKAGTAYHKIVNAHIYEDQLELMQSVQLKRSPFPSPQLSINPDIKSLEDLETWVTMDDFEVTGYEHHEGIRYPFSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COSA_ORYSJ
Sequence: MNVEEEVGKLKEEIQRLGQKQPDGSYKVTFGVIFNDDRCANIFEALVGTLRAAKKRKIVKYDGELLLQGAHDNVEITLLPPPAVAAA
What are the official names of this protein?
Costars family protein.
What is the protein family that this protein belongs to?
Belongs to the costars family.
Protein: NOCT_RAT
Sequence: MYQSPRRLCSALLLRDAPGLRRTLVPGPRRTLAPPVLGSRPASPQLQAAASGAARSRPRTVSPMGNGTSRLYSALAKTINSSAAAQHPEYLVSADPEHLEPIDPKELLEECRAVLHTRPPRYQRDFVDLRTDCSSSHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQSRFKLINSTNIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITEGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSPDGQSEPPYTTWKIRTSGECRHTLDYIWYSRHALSVTSALDLLTEEQIGPNRLPSFHYPSDHLSLVCDFSFNEEPDELL
What is the function of this protein?
Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (By similarity).  Shows a small preference for NADPH over NADP(+) (By similarity).  Represses translation and promotes degradation of target mRNA molecules (By similarity).  Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity).  Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity).  Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity).  Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity).  Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity).  Critical for proper development of early embryos (By similarity).
What are the official names of this protein?
Nocturnin, Carbon catabolite repression 4-like protein.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Mitochondrion.
Protein: GUAC_VIBA3
Sequence: MRIEQELKLGFKDVLFRPKRSTLKSRSQVELTRDFTFKHSGRQWSGTPVIAANMDSVASFEMAAALAEHGVMTAVHKHYTVEQWAEFAKTADKKTLNNVFVSTGTSEAEFEKVKKIMALSEEFVFICIDIANGYSEHLVEFVQKVRAEFPTKVISAGNVVTGDMVEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECGDAAHGLGGMIIGDGGCSCAGDVSKAFGGGADFVMLGGMLAGHSESGGEVVEQDGKQYMKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPYRGSVHNTISDILGGVRSTCTYVGAAKLKELTKRTTFIRVQEQENNVFGKE
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Protein: SCXN6_MESEU
Sequence: LMTGVESARDAYIAKPHNCVYECFDAFSSYCNGVCTKNGAKSGYCQILGTYGNGCWCIALPGNVPIRIPGKCHR
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Sodium channel neurotoxin MeuNaTxalpha-6.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ESXU_MYCTO
Sequence: MSTPNTLNADFDLMRSVAGITDARNEEIRAMLQAFIGRMSGVPPSVWGGLAAARFQDVVDRWNAESTRLYHVLHAIADTIRHNEAALREAGQIHARHIAAAGGDL
What are the official names of this protein?
ESAT-6-like protein EsxU.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. CFP-10 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX-4 / type VII secretion system (T7SS).
Protein: Y1179_MYCBO
Sequence: MRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQLAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDGNFSDQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDDQTPLVDDTPDADAVRRDTRSQAQRNHDAFLAALRGLLASGELGQHKGLPVTIVVSTTLKELEAATGKGVTGGGSRVPMSDLIRMASHANHYLALFDGAKPLALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLACGPDNRLVEKGWKTRKNAHGDTEWLPPPHLDHGQPRINRYHHPAKILCEQDDDEPH
What are the official names of this protein?
Uncharacterized protein Mb1179c.
What is the protein family that this protein belongs to?
Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.
Protein: HFLX_HAES1
Sequence: MNTNKQFKVYTTSAVDFAQDPTALSSNINAPQFDKAIVVHVFFSQNKNLEDLQEFQLLVKSANVDILSIITTSRSTPQAKYFVGQGKAEEIAQAVEQLNADIVLVNHSLTPAQARNLESICQCRVVDRTGLILDIFAQRARSHEGKLQVELAQLRHLATRLVRRKTGLDQQKGAVGLRGPGETQLETDRRLIKVRITQLQNRLEKVAKQRNQNRQTRRKADIPTISLVGYTNAGKSTLFNVLTQANVYVADQLFATLDPTLKRLPIQDVGNCVLADTVGFIRELPHDLVSAFKSTLQETTEASLLLHVIDVADSRKLENMLTVNEVLSEIKANQVTTLLVYNKIDQVENIQPHIEFDEENQPIAVYLSAQLNQGLDLLVEAIRQKLSHEILHLEINLAAQYGKIRHCFYQLNCVRQEKINEQGEFLLDIQIDKIEWLKLSKQFPLLKRFYETTEISDK
What is the function of this protein?
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
What are the official names of this protein?
GTPase HflX, GTP-binding protein HflX.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=May associate with membranes.
Protein: RL20_FLAJ1
Sequence: MPRSVNSVAKRARRKKIMKQAKGFFGRRKNVWTVAKNAVEKAMSYAYRDRKQNKRNFRSLWIQRINAGARLEGMSYSQFMGKVKANGIELNRKVLADLAMNHPEAFKAILNKVK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NDHI_PROMP
Sequence: MKDFLQKVNSYIKEAFSAGKYLYDGFTVTFDHLRRRPVTVQYPYEKLIPSERYRGRIHYEFDKCIACEVCVRVCPINLPVVDWVMNKETKKKELRNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELATFDRHNLNFDNIALGRLPTNVTTDPSVKPLRELAYLPKGVMDPHEVPPSDVRVGKLPEEVYDWMKPKLNDIKNPTVEPNK
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, NAD(P)H dehydrogenase I subunit I, NDH-1 subunit I, NDH-I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: PYRH_STRA1
Sequence: MEPKYQRILIKLSGEALAGDKGVGIDIPTVQSIAKEIAEVHNSGVQIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQYGVDTRVQTAIPMQTVAEPYVRGRALRHLEKNRIVVFGAGIGSPYFSTDTTAALRAAEIEAEAILMAKNGVDGVYNADPKKDANAVKFDELTHVEVIKRGLKIMDATASTISMDNDIDLVVFNMNETGNIKRVVLGEQIGTTVSNKASE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_BARHE
Sequence: MDTIFAVSSGLLPSGVAVIRLSGSHVVHVVTTLCGCLPKARFMHYGNLTARDGSFLDSALTVFFPAPHSFTGEDCAEFHLHGGKAVVNRFLDELSTFKGCRIAEPGEFSRRAFMEGKLDLVQAEGLADLIEAETESQRRLAVMGTSGRLTTLYRDWRHKLMKIRAFIEAELDFSDEADIPNTVSDKVWKDVENLCISLREHIAEGERASILRDGFKIVIVGAPNSGKSSIMNRLAGKPVAIVTEEAGTTRDALEVRLVLGGLPVFLIDTAGFRETDNKIEQLGIEVAKQHVRDADLVILVYDMQNPKEVYLPETSAEIWRVGNKFDLYEENKEPWLIQFSALTGLNFDHFMKELESFCLRRVSEIGNLFPARKRQLQLLKEAVKEIENSVNYDSLDLSLRAEHLRRASDFLGKITGDIDVEDLLDIIFSEFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THR_DROVI
Sequence: MSLGDVKEQLRGSRTEAKNAAKLIQVQFERVRNGGTTSVALRALKYELNILRQLCCALQENFHQHADIYCDIAADMLPHVAPHLPQPDYWVNHLMSLQYIHHALCREQTIKQCQRFYELINAQSCQMQNKSEYKYYIDIHIRHVYFFGHQLGKQSAASEAKAQLCQALQALGKLLENMLQLKAEQNEGYSELMGELNQLLGKRSIGYLKNLASLPLTAMNRLWKPLFKLIACNGGTTDQLNAQFSEYLSALLALLQLDDNVWQLQQSEAQAQTPLSLQLLHSCRELYKNQTAQNNVLQLLYNYLKLLNTQSADLKRSYIDLAKKFVHFFEHKAVSHVQEQWYLDFLFVLVRVQKHLHQIDNKVPSLERFWQCLGGQDSATAYAAHFELLQCLTSRVMKIGRGSPLAASCSGNDASCPSVLKHCVFTLGCCATVAYSSWQPEAQATLPKASQLCLASIIHYAIDVAKVTKCLTPNSSELVTFAWYLINMAEKVTTATQMYLLEHLLKPLQELRPLLSPPYAQQLVRRLFKASAHSSNPELSALLHGAYIVSMSCPARQFQQLCVFYHTPKNDTEQCLLELCEKSPLCSPLNATEKRKLYELDMLAVLANKKTPKLLQSLLRHCQTDYQMVLLGRQMRTDKRSAGQQIEELRVRLQRLGRKQQLTRLQQLILGHATVTKLLEAAETQKIKIHIKEMTEKTLEVLLVKYKLFDLTISSEMPLLELATTAIGAFESFYEQADAEPLSSDEALIDWEALIDDGIAAAMALSTMGYIPQADNAWLLLLRICRLLGDRFNYLRALSHFLPRYTQHALFDLPAEVSHAEQLLDELWPQLHAAHLLKRHHTTVLLCLCNLALYYARLDCVRHAQLLLLHAQRLRLEFEERAGKCDIIQLTIQTVRFRMCYQQRHCRSLARLPTALQQLDTLTESVRSFTCISSMDNGALILLLGDMVRDTTECTANRLSELPNFSNSLLQLLLQSGLVLRAVELLISWLWTNLRMECLDKAHSKLRLIEHFLGMQPLLESRAALEQTSNKGSLTLAPMDAQSKHMTELVGKMLVMQLEQSGACVEPIRKQQQLTMSSPRRELPLPSARPKLQRYVSLDMQQSHPMLRSSVQLQCIYFMAGCLHARLYFLNREHEQLDDFYALANAWLQQNAARGNALGHMLLVLHIYQANYLRARRRQQQAIELTETALKLAGSEQLQQRIDVNYRYNLLLQLRTAQLELEPPSKPQNPRRALTFNISPEEKLPRPVRKVATASKKPAKFAIYTEDVRPASSTTSSSSSSSSSENASSPERKSTKSKSPKRLDLNACQLIDIIDLSDDETEAVVQLQPAKSTSALSTRSTRTRAQRQPDTLVAPLRRTATAPNPLSAEATPKTIGTRARARRQNTAEQPTTTTTATPKVDSVSSRRRHRN
What is the function of this protein?
Required specifically for chromosome disjunction during all mitoses; maternally provided protein is sufficient until mitosis 14 then zygotic protein is required.  Involved in formation and/or maintenance of epithelial structures: bud extension during Malpighian tubule development, and foregut and hindgut morphogenesis (By similarity).
What are the official names of this protein?
Protein three rows.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BHE40_HUMAN
Sequence: MERIPSAQPPPACLPKAPGLEHGDLPGMYPAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD
What is the function of this protein?
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297).  Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706).  Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144).  Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:15560782).  Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706).  Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558).  May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (PubMed:19786558).  Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (PubMed:28797635).  Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868).
What are the official names of this protein?
Class E basic helix-loop-helix protein 40, bHLHe40, Class B basic helix-loop-helix protein 2, bHLHb2, Differentially expressed in chondrocytes protein 1, DEC1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus (PubMed:11278694).
Protein: MCSB_BACC2
Sequence: MSLDKIMNEAISPWMKGDGPDSDIVLSSRIRLARNFKQYQFSTMQNEEEAKQIHELFKKKFINKAVGSFGEFGLLKMNELTPLQRRVLVEKHLISPNLAGTEYGACLLSESEHISVMLNEEDHIRIQCLFSGLQLSEALQSANQIDNWIEKEVEYAFDESLGYITSCPTNVGTGLRASVMIHLPGLVLTKRISRIIQVIQKLGLVVRGIYGEGSEALGNIFQVSNQMTLGKSEEDIIADLKSVIQQIIQQEKMARELIVQNSSIELEDKVYRSYGILANSRLIQSAEAANCLSDVRLGIDLGYIKGISRNILTELMVLTQPGILQQYAGGPLGPEERDYRRATLIRERLSIEKN
What is the function of this protein?
Catalyzes the specific phosphorylation of arginine residues in a large number of proteins.  Is part of the bacterial stress response system.  Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
What are the official names of this protein?
Protein-arginine kinase.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: NDHM_ACAM1
Sequence: MLLKSTTRHIHIYTAEVENNELIPSESVLTLDVDPDNELVWSEDALQRVYAKFDELVETYSGEDLTDYNLRRIGSDLEHYVRSLLQKGIVGYNLSSRVRNFSMGLPQVIASESK
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit M, NAD(P)H dehydrogenase I subunit M, NDH-1 subunit M, NDH-M.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhM subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y3084_CORGL
Sequence: MERNEVAPGMLLVAAPDMASEDFERSIVLIIEHSPATTFGVNISSRSDVAVANVLPEWVDLTSKPQALYIGGPLSQQAVVGLGVTKPGVDIENSTSFNKLANRLVHVDLRSAPEDVADDLEGMRFFAGYAEWAPGQLNEEIEQGDWFVTPALPSDIIAPGRVDIWGDVMRRQAMPLPLYSTFPSDPSDN
What are the official names of this protein?
UPF0301 protein Cgl3084/cg3414.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: HTPX_PSE14
Sequence: MMRILLFLATNLAVVLIASITLSLFGFNGFMAANGVDLNLNQLLVFCAVFGFAGSLFSLFISKWMAKMSTGTQIISQPRTRHEQWLLQTVEQLSRDAGIKMPEVGIFPAYEANAFATGWNKNDALVAVSHGLLERFSPDEVKAVLAHEIGHVANGDMVTLALVQGVVNTFVMFFARIIGNFVDKVIFKSENGQGIAYYITTIFAELVLGFLASAIVMWFSRKREFRADDAGARLAGTDAMIGALQRLRSEQGVPVNMPDSLTAFGINAGLKKGLAGLFMSHPPLEQRIEALRRRG
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LSPA_CHLTE
Sequence: MALFYLLAIAAALLDRVTKLLAIHYLRDGAQSIVIIPDWLKLTYAENLGIAFSVRFLPPTGLLFLTLAISAGVVWYVHKSNNRSPLFLTAFGLILGGGIGNLIDRVMLGHVVDFIYFDLYHGALFGIPLDLWPIFNVADSCITIGACMIVLFHEKIFTRKHA
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBIG_SALHS
Sequence: MNTEKPSVAHNVDHNEIAKFEAVASRWWDLEGEFKPLHRINPLRLGYITERSGGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGIEVEYVQETVEEHAAKHAQQYDVVTCMEMLEHVPDPQSVVHACAQLVKPGGEVFFSTLNRNGKSWLMAVVGAEYILRMVPKGTHDVKKFIKPAELLSWVDETVLKEQHITGLHYNPITNTFKLGPGVDVNYMLHTRAKKA
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.