PharMolix/UniProtQA huggingface dataset:
Protein: HIS1_CAMJE
Sequence: MQENTRLRIAIQKSGRLSKESIELLSECGVKMHIHEQSLIAFSTNLPIDILRVRDDDIPGLIFDGVVDLGIIGENVLEENELERQSLGENPSYKLLKKLDFGYCRLSLALPQENKFQNLKDFEGLRIATSYPQLLKRFMKENGINYKNCTLTGSVEVAPRANLADAICDLVSSGATLQANNLKEVKVIYESRACLIQKENALSKEKQALVDKIMLRVAGVMQARESKYIMLHAPKEKLDKIQALLPGVERPTILPLAHDEKNVALHMVSKENLFWETMEALKEEGASSILVLPIEKMLK
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METY2_THET8
Sequence: MEYTTLAVLAGLPEDPHGAVGLPIYAVAAYGFKTLEEGQERFATGEGYVYARQKDPTAKALEERLKALEGALEAVVLASGQAATFAALLALLRPGDEVVAAKGLFGQTIGLFGQVLSLMGVTVRYVDPEPEAVREALSAKTRAVFVETVANPALLVPDLEALATLAEEAGVALVVDNTFGAAGALCRPLAWGAHVVVESLTKWASGHGSVLGGAVLSRETELWRNYPQFLQPDLKGQIPWEALRARCFPERVRTLGLSLCGMALSPFNAYLLFQGLETVALRVARMSETARFLAERLQGHPKVKALRYPGLPEDPAHRNARKYLASGGPILTLDLGDLERASRFLGAIRLLKAANLGDARTLLVHPWTTTHSRLKEEARLQAGVTPGLVRVSVGLEDPLDLLALFEEALEAV
What is the function of this protein?
Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway.  Has weak activity with O-acetyl-L-serine, O-phospho-L-serine, L-serine, O-succinyl-L-homoserine and L-homoserine.  Shows a very low CTT gamma-synthase activity.
What are the official names of this protein?
O-acetyl-L-homoserine sulfhydrylase 2, OAH-sulfhydrylase 2.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
Protein: MIC19_HUMAN
Sequence: MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKAKHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription.  Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180).
What are the official names of this protein?
MICOS complex subunit MIC19, Coiled-coil-helix-coiled-coil-helix domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic19 subfamily.
Protein: HEM1_MAGMM
Sequence: MKLVVVGLNHKSAPVSLREKVAYSSDTLPRSLQALTRLDAVHEGTILSTCNRVEIYMASRDPDAAAAQTSQWIARDHALDPADVTPHLYTKAESEAVRHGFCVASSLDSMVLGEAQILGQMKQAYQDALSAGSTGVVLNRFFQHAFLTAKRVRTETSIAENSVSVASAAVDLAKRIFGDLSGHSCLLIGAGEMCELAARHLVTHGVKEVLVTNRTFSRAVDLAQQFDGHAFPIEALAENLHRADIVISSTGSTVYMVGPDMVKQALKSRRQRPIFLIDIAVPRDLDPEIGQVDSAFLYDMDDLNKIVNDNRQDRAEAAQAAMQIIEGETPLFIQWLDTLDVVPTIKQMRRKAEAAKDQLLQKHLAGWDLSDTDRQRVENLARQLVNKLMHDPTERLRSLTNEHDGDRYIDAARKLYKLDDD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: DBP2_ASHGO
Sequence: MSYAGNRDQQFNRSNFGGRDGDHRGQRPSDRNSYGRDGFGRGGRGGFAGRGRGRSDDRLELTKPDWDVESLPKFEKNFYVEHEDVQKMSTDEVEQFRKENEMKIVGHDVPKPIRTFDEAGFPEYVLKEVKEEGFEKPTAIQCQGWPMALSGRDMIGVAATGSGKTLSYCLPGIVHINAQPLLSPGDGPVVLVLAPTRELAVQIQKECSKFGRSSRIRNTCVYGGVPKSQQIRDLQRGVEILIATPGRLIDMLEIGKTNLKRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVQQLARDYLHDPIQVNIGSLELAASHTITQLVEVVSDFDKRDRLVKHLEIASKDKDSKIIIFASTKRTCDEITSYLRQDGWPALAIHGDKQQQERDWVLNEFRTGRSPIMVATDVAARGIDVKGINFVINYDMPGNIEDYVHRIGRTGRAGATGTAISFFTEANKTLGAQLISIMREAKQEIPQDLLVYDRAPRGGFHPRYGGRGGRGGRGGRGGRGYGGYGGGYGGYGGGYGGGHGGYGGKPKDSGWGNRN
What is the function of this protein?
ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
What are the official names of this protein?
ATP-dependent RNA helicase DBP2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NSTU2_ARATH
Sequence: MGLVDSLLGKDARKFLKRKDSDAAEAGRALEELRSSLYNELKTSEGAKRQQQRFCGPVVAMSFNFVVAVGIILANKLVMGRVGFNFPIFLTLIHYTVAWILLAFFKSLSLLPMSPPSKTTPFSSLFSLGAVMAFASGLANTSLKHNSVGFYQMAKIAVTPTIVLAEFVLFKKTISSTKVMALAVVSLGVAIATVTDLEFNLFGALVAVAWIIPSAINKILWSNLQQQANWTALALMWKTTPFTVFFLLALMPWLDPPGVLLFKWDLTNSSAILISALLGFLLQWSGALALGATSATSHVVLGQFKTCVILLGGYVIFGSDPGFISICGAIAALGGMSVYTWLNLPGKSIDHMSNKQLPKQNVTVSKPKAEADDGGGETGVTVVSVDPLLSKTITANIV
What are the official names of this protein?
Nucleotide-sugar uncharacterized transporter 2.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. TPT (TC 2.A.7.9) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DOF42_ARATH
Sequence: MNNLNVFTNEDNEMNVMPPPRVCPRCYSDQTRFSYFNNNKKSQPRYKCKNCCRCWTHGGVLRNIPVTGICDKSNLPKIDQSSVSQMILAEIQQGNHQPFKKFQENISVSVSSSSDVSIVGNHFDDLSELHGITNSTPIRSFTMDRLDFGEESFQQDLYDVGSNDLIGNPLINQSIGGYVDNHKDEHKLQFEYES
What is the function of this protein?
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
What are the official names of this protein?
Dof zinc finger protein DOF4.2, AtDOF4.2.
What are the subcellular locations of this protein?
Nucleus.
Protein: ADCY2_MOUSE
Sequence: MRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPLIVFLLLIVMGACLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVYLSATPGAKEHLFWQILANVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLFFYNKNIEKEYRATALPAFKYYVTCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASASLLWLLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANASNANVSVPDNQTAILHARNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNIILLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNLAS
What is the function of this protein?
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.  Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production.  Functions in signaling cascades downstream of the muscarinic acetylcholine receptors.
What are the official names of this protein?
Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm.
Protein: SASA_SYNY3
Sequence: MSSSSELGNASSVPLQFLLFIDDRPNSQDSVQEIGQCLTNLLDGHSHDLQILQISKHPHLVEHFRLVATPSLIKLQPEPRQVLAGSNIIQQLQKWWPRWQQELAMDPNPEDTGQSPSCPREISSVGYSGELMKMSDELFLLKKDKEELLQQIQFKDQILAMLAHDLRSPLTAASIAVDTLELLQHKPIEEQKPALRSQLLYQARKQFKIMDRLIEDILQASKNLNSQFQVHGRPLAIADLCQEVLELYQAKFSKKNLTITYDIPKDLPNVFADEELIRQVIANLLDNAIKYTPAHGSITVGALHRTTQKVQVSITDNGPGIPNSKQETIFEGHFRLQRDEQTDGYGLGLSLCRKIIQAHYGQIWVDSRPKQGSSFHFTLPVYR
What is the function of this protein?
Plays an important role in glucose metabolism, important for expression of genes involved in glycolysis, gluconeogenesis, the oxidative pentose phosphate pathway, and glycogen metabolism.  Required for heterotrophic growth (PubMed:15774880).  Overexpression from the psbAII promoter leads to altered levels of genes involved in carbon metabolism, increased levels of transcripts for clock oscillator genes in the light and the dark, complete loss of glycogen accumulation, decreased levels of metabolites of sugar catabolism and increased levels of amino acids in the light and increased levels of SigE protein (PubMed:25403325).
What are the official names of this protein?
Adaptive-response sensory kinase SasA, Sensor histidine kinase Hik8, Sensor histidine kinase SasA.
Protein: USPB_ECOK1
Sequence: MISTVALFWALCVVCIVNMARYFSSLRALLVVLRNCDPLLYQYVDGGGFFTSHGQPNKQVRLVWYIYAQRYRDHHDDEFIRRCERVRRQFILTSALCGLVVVSLIALMIWH
What are the official names of this protein?
Universal stress protein B.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUOB_ANAPZ
Sequence: MGECDQILENDLWQGYKDQGFVVTQFSDLIERVLKWARSGSLWPMTFGLACCAVEMMHTAASRYDLDRYGIMFRASPRQADVMIVAGTLTNKMAPALRRVYDQMADPKYVISMGSCANGGGYYHYSYSVVRGCDRVVPVDIYVPGCPPTAEALLYGLLCLQQKILRNGQGTWRA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y07C_BPT4
Sequence: MSINEYYVYAGDYANPSHFEGNLIPDKVFNTPFEAWSWIESKNGFSYRYVEVTDWRGTKYPKDHYYVNPSKVNFLLFAGDNYYPCGGYDDLIAYAETEDKLRDIIKENENKPDYGSNRFDWWQIVNAHTHAIVDRG
What are the official names of this protein?
Uncharacterized 16.0 kDa protein in segB-ipI intergenic region, ORF3.
Protein: RUVB_BRUC2
Sequence: MSDRNPLIDADRRADEDNTLRPQTLDDFVGQAAARANLKVFIEAAKVRGEALDHVLFVGPPGLGKTTLAQIMAKELGVNFRSTSGPVIAKAGDLAALLTNLEERDVLFIDEIHRLSPAVEEILYPAMEDFQLDLIIGEGPAARSVKIDLAKFTLVAATTRLGLLTTPLRDRFGIPVRLNFYTVEELEYIVRRGARIMQMGISSDGAREVARRSRGTPRIAGRLLRRVRDFALVAGADIIDRRIADEALSRLEVDNRGLDQLDRRYLNIIARNFGGGPVGIETIAAGLSEPRDAIEDIIEPYLIQQGFLQRTPRGRVLTAVAWQHLGLPAPAEIIQQSQYGLFMEDE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CRDS_HELPY
Sequence: MAIALTHYEKKSLKLFLGIYLGSSFVLMLVISVLAFNYEKNEKIKMIRMDMDKMASKIASEVIALHMQTHGDYQNALNALISRYKDASIALFDSKKRVLYSNIPESANLIKNHKEAGFFSFRGEYYLLSDETFAHLGVAKMLFKNSKPLHFSSLYRNIVLVFVVAFLCVIGVSVFLGRLFLKPIRNEITRIDHFLKNTTHELNTPMSALVLSLKTLEDNQQHRRIKIAIQRMSFLYRSLSYLVMQDIERESFVLLDLKALIIKENTLFSEMIDYHKLEFKSDLVEVELKAKEQDFISLYSNLLMNAIKYSVMNGYIHIELTHAFLKVKNLGYEIPKDKITELSVRYVRFNSGVLGYGIGLGLVKKVCEKYKMRLEIHSEPSLKGSFYENSFCVQFQG
What is the function of this protein?
Member of the two-component regulatory system CrdR/CrdS that induces the transcriptional induction of the copper resistance determinant CrdA in response to increasing concentrations of copper ions (PubMed:15968080).  Functions as a sensor protein kinase that phosphorylates CrdR (Probable).  In turn, CrdR functions as a transcriptional regulator by direct binding to promoter regions of target genes including the crdA promoter or nitric oxide-responsive gene promoters (PubMed:26082024).
What are the official names of this protein?
Sensor histidine kinase CrdS.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PYRH_DESHY
Sequence: METPRYRRVILKLSGEALAGSQGFGIAHEMLVTVAEQVVEIQKLGVEVALVVGGGNIWRGIAGSKQGMDRANADYMGMLATVMNALALQDAMEKAGAATRVLSAIEMRQVAEPYIRRRAIRHLEKGRVVIFAAGTGNPYFSTDTTAALRAAEIEAEAILMAKRVDGVYDSDPLKNPEAKKYDRLTFLDVLSQGLGVMDSTAASLCMDNNIPLIVFDLNKKGNIRKGIMGESIGTYVGRDK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_DESOH
Sequence: MVMENEEIRYVRRRKQMVENQIARRGINDPFVLGAMGTVPRHLFVSEALMDQAYGDFPLPIGEQQTISQPYIVAEMTQALEPTGNDRVLEIGTGSGYQAAILSRIVSRVYTVERIHSLYIRARALFDRLGYYNIATRYSDGTTGWKAESPFDRIIITAGAPDIPSVLVDQLAVGGRLVAPVGTESVQSLIKLVKEKTGVRSTDLGGCRFVKLIGEHGWKEN
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK2_PARUW
Sequence: MTLERTLSIIKPDAVGNNHIGEIIARFEKAGLRIVAAKMKQLDRKDAEGFYAVHKGRPFFEDLVGFMTTGPVMIMVLEGENAINKNREIMGATDPKKAAPGTIRADFAQTIDENAVHGSDAAETAKTEIEYFFKSQDVCARKR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase 2, NDK 2, NDP kinase 2, Nucleoside-2-P kinase 2.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBB2_SCHPO
Sequence: MISSAVILVGGPSRGTRFRPLSFDVPKPLFKIGGREMIYHHLAALSKIESVKDVFLVGFYDESVFKDFINEVASHFPSFNRIKYLREYNCLGTGGGLYHFRDQILKGHTSNVFVMHADVCCSFPLQELLNVHHEKKALVTLMATKVSKEDASNFGCLVEEPSTGRVLHYVDKPSSYLSNIISCGIYIFDASIFDEIKKAYERRLEEVEKQLRSLDEGMEDYLSLETDVLAPLCSDSSKAIYAYNTPEFWRQIKTAGSAVPANSLYLQKAYHDGTLPKPDTEAEIIQPVFIHPNAIVSKGAKIGPNVSIGARVRIEDGARIRNSIIQEDCEISANAVVLHSILSRHCKIGKWSRVEGSPTLPSQHSTTIMRNSVKVQAITVMGADCIVHDEVRVQNCLVLPHKEIKVGLVGEIVM
What is the function of this protein?
Involved in cell wall synthesis where it is required for glycosylation.
What are the official names of this protein?
Probable mannose-1-phosphate guanyltransferase, GDP-mannose pyrophosphorylase, GTP-mannose-1-phosphate guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PSBL_MANES
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SUP9_CAEEL
Sequence: MKRQNIRTLSLIVCTLTYLLVGAAVFDALETENEILQRKLVQRVREKLKTKYNMSNADYEILEATIVKSVPHKAGYQWKFSGAFYFATTVITTIGYGHSTPMTDAGKVFCMLYALAGIPLGLIMFQSIGERMNTFAAKLLRFIRRAAGKQPIVTSSDLIIFCTGWGGLLIFGGAFMFSSYENWTYFDAVYYCFVTLTTIGFGDYVALQKRGSLQTQPEYVFFSLVFILFGLTVISAAMNLLVLRFLTMNTEDERRDEQEAILAAQGLVRVGDPTADDDFGRLPLSDNVSLASCSCYQLPDEKLRHRHRKHTEPHGGPPTFSGMTTRPKY
What is the function of this protein?
Potassium channel involved in coordination of muscle contraction (PubMed:14534247).  Activity is regulated by sup-18 (PubMed:24586202).
What are the official names of this protein?
Two pore potassium channel protein sup-9, Suppressor of unc-93 protein 9, n2P38.
What is the protein family that this protein belongs to?
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Note=Associated with dense bodies.
Protein: UNG_SALPB
Sequence: MATELTWHDVLADEKQQPYFINTLHTVAGERQSGITVYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGIAPPPSLVNMYKELEASIPGFVRPAHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDPQRHHILKAPHPSPLSAHRGFFGCNHFALTNQWLEQHGEKTIDWTPVLPAESE
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_SYMTH
Sequence: MKTELSEVWQQCIDHLERHTSKTAIENWVRSTRPVAVVEDTIIVGVQGEFAKHRMESRYAPLLRQALRDLTKRNMQLKFVANPNVIEDPAAEPVDAPNVADLPAGTSAPAAEQNARLLGYINPKYTFETFVVGNSNRFAHAAALAVAETPARTYNPLFIYGGVGLGKTHLMHAIGHYVLQHNPTAKVAYVSTETFTNEFIMAIQKGSTTAFQNRYRKVDVLLIDDIQFLAGKEATQEEFYHTFNAIREANKQIVISSDRPPKEIPTLEDRLRSRFEWGLICDIQPPDLETRTAILRKKAQSEGIQVPDEVTNYIATNIETNIRELEGALTRVVAYANMLKCPLTYDLAVQALKDILPPVRPKQITIATIKQVVAEHYNIRMQDFEVRNRSRAVAYPRQIAMYLARELTDSSLPKIGEEFGGRDHTTVIHACEKIAKDIQSDPAFAHTIEQLIARIRAE
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILM1_YEAST
Sequence: MAQALNSTNIAFFRVAFLFTIAFFCLKNVNSILQNTYFIVLTQAMNLPQLTLSRYSGQLGLFALLFTLNGVHDLIPLLENNVKYFQSVVPVRLLIFFILTSISYLWESNFYVHNNSVFIYCFAEVWINFLLYNAIREEKNEEFKRLNQFMVNDEDIEEPQPFTVKTETTEIIEIINDEENDDEDGKDNDDNNEKGNDDSDAKK
What are the official names of this protein?
Protein ILM1, Increased loss of mitochondrial DNA protein 1.
What is the protein family that this protein belongs to?
Belongs to the ILM1 family.
Protein: RS15_LIMF3
Sequence: MAISKEKKNEIIKQFATHEGDTGSTQVQVAVLTADINELNEHLREHKHDYHSQRGLMKKIGHRRNLLAYLRRTDLPAYRELIKALGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: DEF_THEP1
Sequence: MYRIRVFGDPVLRKRAKPVTKFDDNLEKTIERMIETMYHYDGVGLAAPQVGISQRFFVMDVGNGPVAVINPEILEIDPETEVAEEGCLSFPEIFVEIERSKRIKVRYQNTKGEYVEEVLEGYAARVFQHEFDHLNGVLIIDRISPAKRLLLRKKLMDIARTVKR
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: CDNF_HUMAN
Sequence: MWCASPVAVVAFCAGLLVSHPVLTQGQEAGGRPGADCEVCKEFLNRFYKSLIDRGVNFSLDTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEKLKKLDSQICELKYEKTLDLASVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKYAATHPKTEL
What is the function of this protein?
Trophic factor for dopamine neurons.  Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons.  When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
What are the official names of this protein?
Cerebral dopamine neurotrophic factor, ARMET-like protein 1, Conserved dopamine neurotrophic factor.
What is the protein family that this protein belongs to?
Belongs to the ARMET family.
What are the subcellular locations of this protein?
Secreted.
Protein: FPG_CORJK
Sequence: MPELPEVEVVRRGLEEHLVGRRFTDVQVCHPRAVRSGEPEVLVSSLRDATVTAVKRRGKFLWLDFGEDFLLQVHLGMSGQMLVAEPGQVQSPHVRIRAGLSDGRELCFVDQRTFGEWRLEKAVPDPWAAGAGVASPKNFLPQNVSHIAADPLEAVFDAQAAVARMKSKRAAVKTVLLNQEVVSGIGNIYADEALFLAGVRPRRSAALLSRPTLHRVLQSAAEVMECALEQGGTSFDSLYVNVNGASGYFSRSLNVYGRGGEPCKRCGAPIKRVVVGGRSTHYCATCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.