PharMolix/UniProtQA huggingface dataset:
Protein: NUON_LEPIN
Sequence: MNLFDLSILPFLNLAQVVNESRVPNVPDLLSVLPALVLATGGVFLICLSVLFKTKEFIIVRYVSGLILLLAFAAVFYTSFRFPGNGFHFSGQIENSVLSFWLNLIYISMAIGTAAIVPRILKNHKIEFPEFYPLLLFATCGMTLMTTGQDFILVFVALELMSICLYILIGMARSDLFSLEATLKYFLLGSFSSGFMLMGIAFLFGGSGSTNITEALKPLTIAGYQGNFAKIGLVLFITGVAFKIALFPYHAWTPDAYEGALTPVTGYMSTAAKAASIGLLLILYTKLPLPLENSTWAWLPGILALCSMIYGNLLALKQENLKRMLAYSSIAHAGYVVAGISAGIKEEVLFYLIVYSFMSLGAFAILAYLEEGTRQVTFFSVQSLSGVKPLTAIAINIFFMSLAGVPPFGGFWAKLFLFQKLAESETLMNRILLIGGVTNSALALYYYLRIGIATFMSSDEGEISRNHAAPYSVGVTGVVLFCLLMVSVGWFLLVPGNLLALGELWLSSSIFR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSMG_SPHAL
Sequence: MIIPHRADGGKNDVSAAELLKDERAARGWLTQAFAPSTEQWAQIERFVTMLIAENAKQNLIAASTIPAIWARHIADSAQLLALDTREGEGLWIDLGSGPGLPGLVVAILSERPMLLVESRRRRCDFLRAVVAELALDHVEVAEAPLERVATRPAATISARAFAPLDRLIDLSARFSTESTRWLLPKGRNAVKELALLPEPWQRMFHVEQSRTDAESGILVGTGRIAPKKRGKA
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLCB_ARATH
Sequence: MVEEDLNQIGGNSNYNGEGGDPESNTLNQPLVKANRTLSSTPLALVGAKVSHIESLDYEINENDLFKHDWRKRSKAQVLQYVFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGHFLTQERYVTGLMVLVGANLGLTLVASVLCVCFAPTAAGPGIPEIKAYLNGVDTPNMFGATTMIVKIVGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGTDNHRIKWRWLRYFNNDRDRRDLITCGSAAGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLREFIEICNSGKCGLFGKGGLIMFDVSHVTYTYHVTDIIPVMLIGVIGGILGSLYNHLLHKVLRLYNLINEKGKIHKVLLSLTVSLFTSVCLYGLPFLAKCKPCDPSIDEICPTNGRSGNFKQFHCPKGYYNDLATLLLTTNDDAVRNLFSSNTPNEFGMGSLWIFFVLYCILGLFTFGIATPSGLFLPIILMGAAYGRMLGAAMGSYTSIDQGLYAVLGAAALMAGSMRMTVSLCVIFLELTNNLLLLPITMIVLLIAKTVGDSFNPSIYDIILHLKGLPFLEANPEPWMRNLTVGELGDAKPPVVTLQGVEKVSNIVDVLKNTTHNAFPVLDEAEVPQVGLATGATELHGLILRAHLVKVLKKRWFLTEKRRTEEWEVREKFPWDELAEREDNFDDVAITSAEMEMYVDLHPLTNTTPYTVMENMSVAKALVLFRQVGLRHLLIVPKIQASGMCPVVGILTRQDLRAYNILQAFPLLEKSKGGKTH
What is the function of this protein?
Voltage-gated chloride channel.
What are the official names of this protein?
Chloride channel protein CLC-b, AtCLC-b, CBS domain-containing protein CBSCLC7.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SMG7_HUMAN
Sequence: MSLQSAQYLRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPLQNESQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPHEEDLSSISATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQETSVIESLAADGSPGLKSVLSTSRNLSNNCDTGEKPVVTFKENIKTREVNRDQGRSFPPKEVRRDYSKGITVTKNDGKKDNNKRKTETKKCTLEKLQETGKQNVAVQVKSQTELRKTPVSEARKTPVTQTPTQASNSQFIPIHHPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQPTAHSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGPQQSQPPSQQPLTSLPAQPTAQSTSQLQVQALTQQQQSPTKAVPALGKSPPHHSGFQQYQQADASKQLWNPPQVQGPLGKIMPVKQPYYLQTQDPIKLFEPSLQPPVMQQQPLEKKMKPFPMEPYNHNPSEVKVPEFYWDSSYSMADNRSVMAQQANIDRRGKRSPGVFRPEQDPVPRMPFEKSLLEKPSELMSHSSSFLSLTGFSLNQERYPNNSMFNEVYGKNLTSSSKAELSPSMAPQETSLYSLFEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHNHNSVPFSNFGPIGTPDNRDRRTADRWKTDKPAMGGFGIDYLSATSSSESSWHQASTPSGTWTGHGPSMEDSSAVLMESLKSIWSSSMMHPGPSALEQLLMQQKQKQQRGQGTMNPPH
What is the function of this protein?
Plays a role in nonsense-mediated mRNA decay.  Recruits UPF1 to cytoplasmic mRNA decay bodies.  Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
What are the official names of this protein?
Nonsense-mediated mRNA decay factor SMG7, SMG-7 homolog, hSMG-7.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.
Protein: RL1_HAMD5
Sequence: MSKLSKRMRVIREKVDTAKQYDLDDAFLLLKKLATAKFTESVDVAVNLGIDARKSDQNVRGATVLPHGTGRSVRVAVFTQGANAEAANNAGAELVGMDDLAAQIRNGEMNFDVVIASPDAMRVVGQLGQILGPRGLMPNPKVGTVTPNIAEAVTNAKAGQIRYRNDKNGIIHTTIGKIDFDAHKLKENLEALISALKKAKPATAKGLYIKKISLSTTMGAGLMIDQSALSSLV
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: SWT21_YEAS7
Sequence: MEKKVICQDIFWSCDGTSFVSVHNDFGIRQYLVPEESNTDKLNRNLLLPFTRFFRNQSIVSCAIDPFYTLYNENSDRLAGDRIVVGGKNFPLQLYSLMDGQCILSYDTMNKINGEYETVYSVKIDVESRVYTGSCRNKVAIYDKSRRDAVWMNQSTKKASKGRQSIISCFEEQPMGGQALSRGSLLCGSYANEMFQVDCRHQRLERLNYTRTVAGGIVQILTSDNGRYVYVVRRNSDAISIYDRRNLQHELNVLRLPFRIHHNSAKLKAYIDTAYGLSMGTPQGTILNWGRDLVEFGGVPSHNSVEDPLITSIPPESEWRTNLDSTIPATVVKNCPGDPELFALSHGGTISLCRFGG
What is the function of this protein?
Involved in mRNA splicing.  Helps to stabilize the U1 snRNP-5' splice site interaction (By similarity).
What are the official names of this protein?
Protein SWT21, Synthetic With TGS1 protein 21.
What is the protein family that this protein belongs to?
Belongs to the SWT21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FUS_HRSVR
Sequence: MELPILKTNAITAILAAVTLCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKSAVTELQLLMQSTPATNNRARRELPRFMNYTLNNTKNTNVTLSKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPLAETCKVQSNRVFCDTMNSLTLPSEVNLCNIDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKDRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
What is the function of this protein?
Major determinant of the species specificity of RSV infection.  The trimer of F1-F2 (F protein) also facilitates the attachment to host cell by binding to host heparan sulfate.  F protein is involved in the entry into the host cell through the interaction with host IGFR1.  This interaction activates PRKCZ/PKCzeta that recruits host NCL/nucleolin to the apical cell surface where it can bind fusion glycoprotein F1.  Later in infection, F protein expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.  F protein seems to trigger p53-dependent apoptosis.
What are the official names of this protein?
Fusion glycoprotein F0.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
[Fusion glycoprotein F0]: Host Golgi apparatus membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: [Fusion glycoprotein F1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein. Note=Localized at the host apical membrane. SUBCELLULAR LOCATION: [Fusion glycoprotein F2]: Virion membrane. Host cell membrane. Note=Localized at the host apical membrane.
Protein: PATR_MYCA9
Sequence: MPARLRPELTELPAYTPGRNVPGAIKLASNETVQEPLPSVRAALAEAGSLINRYPDNGYAELRSHLAKHVDMPPEHIAVGCGSVSLCQQLVQITATVGDEVLFGWRSFETYPLVVRVAGATPVQVPLVDHTYDLAAMAAAVTDVTRLIFVCNPNNPTGTVVRPAELRRFVESVPPHILIAIDEAYVEYVREDFTDSLALVREHPNVVVLRTFSKAYGLAGLRVGYAVGDPDVITTLGKVYVPFSASSLAQAAAVASLGAAEELLARTNDVVTERARVTSALREAGYQVPPSQANFVWLPLGERSTEFAQASAEARIIVRPFGTDGVRVTIGAPMENDAFLKFSRAWR
What is the function of this protein?
May catalyze the transamination reaction in phenylalanine biosynthesis.
What are the official names of this protein?
Putative phenylalanine aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: RL1_STAA2
Sequence: MAKKGKKYQEAASKVDRTQHYSVEEAIKLAKETSIANFDASVEVAFRLGIDTRKNDQQIRGAVVLPNGTGKSQSVLVFAKGDKIAEAEAAGADYVGEAEYVQKIQQGWFDFDVVVATPDMMGEVGKLGRVLGPKGLMPNPKTGTVTMDVKKAVEEIKAGKVEYRAEKAGIVHASIGKVSFTDEQLIENFNTLQDVLAKAKPSSAKGTYFKSVAVTTTMGPGVKIDTASFK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: PPM1J_MOUSE
Sequence: MLNRVRSAVAHLVSSGGTSSQRSKSPDLPNATSAPPAAQETPKSSREKPGNQVGAPQKTAETTVSFSRPTFLQLSPGGLRRADDHAGRAVQSPPDTGRRLPWSTGYAEVINAGKSRHNEDQACCEVVYVESRRSRSVTGVSREPSHNQGFCFYYWGLFDGHAGGGAAEMASRLLHRHIREQLKDLVEILKDPLPPPLCLPSTPGTPGAPSPSQLVSPQSCWSPQKEVTHDSLIVGAIENAFHLMDEQMARERRGHQVEGGCCALVVLYLLGKMYVANAGDSRAIIVRNGEIIPMSREFTPETERQRLQLLGFLKPELLGSEFTHLEFPRRVQPKELGQRMLYRDQNMTGWAYKKIEVEDLRFPLVCGEGKKARVMATIGVTRGLGDHNLKVCSSTLSIKPFLSCFPEVRVYDLTQYEHCPDDVLVLGTDGLWDVTNDSEVAATVDRVLSSYEPNDPSRYTALAQALVLGARGIPRDRGWRLPNNKLGSGDDISVFVIPLGGPGSSYS
What are the official names of this protein?
Protein phosphatase 1J, Protein phosphatase 2C isoform zeta, PP2C-zeta.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: HIS7_SALAI
Sequence: MSRTARIERVTKETKVLVEIDLDGTGKADIETGVGFYDHMLHQIARHGGFDLTVHTVGDLHIDAHHTMEDAALALGAAVDRALGDRAGIRRYGAATVPMDEVLVRAAVDLSGRPYVVHDEPPLAPYIGPVYPTSMTRHIWESFGQSARITLHVDVLRAARPGGHPDAHHVVEAQFKAVSRALREATSLDPRFTGVVPSTKGTL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_MARMS
Sequence: MTHYILAIDQGTTSSRAILFDEKGSRVGQSQQEFPQIFPDDGWVEHDPEDIWSSTLAVCRSVLKDTGIDAQAIATIGITNQRETTILWDIDTGKPVYNAIVWQDRRTSGFCQSLSDQGLSEKVQEKTGLLIDPYFSATKIRWILDNVDGARETAQSGRLAFGTVDSFLLWRLTNGKSHKTDATNAARTMAFNIHTQEWDDELIELLGIGDVLFPEVMDCSADFGVIDASWLGAEIPVNGIAGDQQAALVGQACFTPGMVKSTYGTGCFMILNTGDKAIRSEHKLLTTVGYRLNGKVTYALEGSIFVAGAAIQWLRDGLKLFADAKETQSLAKQALNDDSVYLVPAFTGLGAPYWDPDARGAMIGLTRDTSVADIVSAGLRSVCYQTKDLVGAMAQDGATFSSLRVDGGMVINDVMVQFLSDLLEITVERPCVTETTALGAAFLAGLQVGLYQSLDEIEVLWKADKCFEPTMEKGTGDKLYQGWQKAVDRVRTRD
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: CNN3_HUMAN
Sequence: MTHFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGPNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYQDDYPRDYQYSDQGIDY
What is the function of this protein?
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction.  It is capable of binding to actin, calmodulin and tropomyosin.  The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
What are the official names of this protein?
Calponin-3, Calponin, acidic isoform.
What is the protein family that this protein belongs to?
Belongs to the calponin family.
Protein: RS12_SYNWW
Sequence: MPTINQLVRKGREKGEQKSTAPALKSCPQKRGVCTRVYTTTPKKPNSALRKIARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIIRGTLDASGVQKRNQGRSKYGTKRPKKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: FADJ_SHEAM
Sequence: MEKTFSLSRRDDGIALLTMDVPGETMNTLKAQFAPEITAILQEIKADSSIKGLVLISGKADSFVAGADISMLDACETAEDARLLSRQGHHVFAELEGLNIPVVAAIHGACLGGGLELALACHQRVCSDSSKTMLGVPEVQLGLLPGGGGTQRLPRLIGIAKALDLMLTGKQVRPKQAVKMGLVDDVVPESILLDTAIEMALAGKKTRKPLKQPLVTKLLEGTPVGRNIMFDQATKQVLKKTQGNYPSPLKIIDCVREGMAKGMEKGLEVEAAHFGALVATPESAALRSIFFATTEMKKETGAGDAKPRKVAKAVVLGGGLMGGGIASVTTTKAKVPVRVKDISDKGLSNALGYAYKLLDKGVKRRHMTSAERDKLMALMTTTTEYRGVKDADIVVEAVFEDLNLKHQMVRDIERECGEHTIFASNTSSLPITQIAAAASRPENVIGLHYFSPVEKMPLVEVIAHEKTSPETIATTVAFARKQGKTPIVVKDCAGFYVNRILALYMNEAAQLLLEGQAVDHLDKALVKFGFPVGPMTLLDEVGIDVGAKISPILEKELGERFKAPAAFDKLMADDRKGRKNGKGFYLYGKAAKKGKKVDESVYSLLGLTPATGKEAGEIAERCVVQMLNEAVRCLEEGIIASPRDGDIGAIFGIGFPPFLGGPFRYMDTLGAAKMVRLLEGYQSKYGDRFAPAALLKAMAAEGKTFY
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_PROMH
Sequence: MSLSTEAKAKIVAEFGRDANDTGSSEVQIALLTAEINHLQGHFSEHKKDHHSRRGLLRKVSSRRNLLDYLKRKDVARYTALIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: URE3_VARPS
Sequence: MELTPREKDKLLIFTAALLAERRKARGLKLNYPEAVALISAAVMEGARDGKSVAALMSEGRTVLTRADVMDGIAEMIPDIQVEATFPDGTKLVTVHQPIV
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_MYCPN
Sequence: MPIKKIISRSNSGIHHSTVIDYKKLLTTNKNKPEKSLLVTLKKHGGRNNQGKITVRHQGGRNKRKYRIIDFKRTHYDNIEATVKSIEYDPNRSCFVSLITYANGAKSYIISPDGIKVGDKILASEHPIDIKPGFSMPLAFIPEGTQVHNIELHPKGGGQIARSAGSYARILGQDETGKYVILQLLSGETRKFLKECRATVGVVSNLDHNLVVIGKAGRNRHRGIRPTVRGSAMNPNDHPHGGGEGRSPVGRDAPRTPWGKRHMGVKTRNMKKASTNLIIRNRKGEQY
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ATG1_PENRW
Sequence: MASQHSRRSREAPRPEMSIGRYTRLDEIGRGSFATVYQGVHTKSKTYVAIKSVNLSKLNKKLKENLSSEIDILKGLHHPHIVALIDCHESTSHIHLVMEYCALGDLSLFIKRRDTLGSHKYTRDMIAKYPNPPGGSLNEVVTRHFLKQLSSALKFLRDRNLIHRDIKPQNLLLCPSPSSYRSGHAQVMPYKGSDDSYEPTTGLESLPMLKIADFGFARSLPATSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVVGRPPFRATNHVELLRKIEKGEDRIRFPEDNPASDDIKKLIRGLLKRNPVERLNFPEFFSNNVINDPIPGLLADDAPGPPQSPRPRQLVGKAEESPYDTGPEDKLAYPPGQRPVTTHPKSGTPPTATDMRRMGSADRPAPAISKEQQPGGTPPQRPGPVSLATAPGRQELIDRNATTAAMDRQRHRNTYAGAPKASDSTIRAQEARDRAAQEVAFERDYVVVEKRAVEVNAFADELAHSPRLQGGLSRPGQTGAGSRRTTTQGLPTVSPSSPHANAAKAMQVVSGRARADSTHQRQHSYERRYGQSPTSATSAISKALNMASGRLFGMGFSPPLAITKGGRSPPLAYNPFPAYPPVHASLLITGDGSKPNATGDEDCKAVQEIEECATRSDVVFGFAEVKYKQLIPLAPSASTDPSARPMDTNVEPDSADSDDGLTVDAIVTLSEEALVLYVKALSLLAKSMDIAGAWWSRKNREEVYGESPTKDSMSAVAGTRINYVVQWVRSRFNEVIEKAEFVRLKLIEGQRRLPPDHPSHPDNHSISSTAGSSSTADVVVSPGVTAERLMYDRALEMSRAAAINELTGEDLANCEITYVTAIRMLEAVLEDDGMRSMPGSNIERQSSSQGGEKVVLDELQVEDRQVVVKLVSSMRGRLASVRKKVAVLAKRSSAPTPTAGSAGKTPTSNISPVTYATGVTPPR
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes (PubMed:17204848).  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8 (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase atg1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: ONEC3_HUMAN
Sequence: MELSLESLGGLHSVAHAQAGELLSPGHARSAAAQHRGLVAPGRPGLVAGMASLLDGGGGGGGGGAGGAGGAGSAGGGADFRGELAGPLHPAMGMACEAPGLGGTYTTLTPLQHLPPLAAVADKFHQHAAAAAVAGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFTLMRDERAALASVGHLYGPYGKELPAMGSPLSPLPNALPPALHGAPQPPPPPPPPPLAAYGPPGHLAGDKLLPPAAFEPHAALLGRAEDALARGLPGGGGGTGSGGAGSGSAAGLLAPLGGLAAAGAHGPHGGGGGPGGSGGGPSAGAAAEEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQKERALQPKKQRLVFTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRRCMNRWAEEPSTAPGGPAGATATFSKA
What is the function of this protein?
Transcriptional activator.  Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).
What are the official names of this protein?
One cut domain family member 3, One cut homeobox 3, Transcription factor ONECUT-3, OC-3.
What is the protein family that this protein belongs to?
Belongs to the CUT homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SRTD2_HUMAN
Sequence: MLGKGGKRKFDEHEDGLEGKIVSPCDGPSKVSYTLQRQTIFNISLMKLYNHRPLTEPSLQKTVLINNMLRRIQEELKQEGSLRPMFTPSSQPTTEPSDSYREAPPAFSHLASPSSHPCDLGSTTPLEACLTPASLLEDDDDTFCTSQAMQPTAPTKLSPPALLPEKDSFSSALDEIEELCPTSTSTEAATAATDSVKGTSSEAGTQKLDGPQESRADDSKLMDSLPGNFEITTSTGFLTDLTLDDILFADIDTSMYDFDPCTSSSGTASKMAPVSADDLLKTLAPYSSQPVTPSQPFKMDLTELDHIMEVLVGS
What is the function of this protein?
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors.  May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression.  Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
What are the official names of this protein?
SERTA domain-containing protein 2, Transcriptional regulator interacting with the PHD-bromodomain 2, TRIP-Br2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.
Protein: SYN_SHEON
Sequence: MSIASVASVFKGEHAVGSTVTVRGWVRTRRDSKAGISFLAVYDGSCFNPIQGVVPNSLENYDNEVLKLTAGCSVIVTGDIVESPGAGQAYELQVTAVEVTGWVEDPDTYPMAAKRHSIEHLRELAHLRPRTNIIGAVARVRNCLSQAIHRFYHENGFVWVSTPLITASDCEGAGEMFRVSTLDMENLPRTSDGKVDYDKDFFGKEAFLTVSGQLNGETYACALSKIYTFGPTFRAENSNTSRHLAEFWMVEPEVAFATLNDIAGLAEGMLKYAFNAVLTERMDDLQFFAQHVDKTVIERLQSFVSSDFAQVDYTDAVEILQKSGREFEFPVSWGIDLSSEHERYLAEEHFKAPVVVKNYPKDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDMRLEEMDLNKEDYWWYRDLRRYGTVPHAGFGLGFERLVSYVTGVSNIRDVIPFPRAPRTANF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HVM53_MOUSE
Sequence: MNFGLRLIFLVLVLKGVLCDVKLVESGGGLVKLGGSLKLSCAASGFTFSSYYMSWVRQTPEKRLELVAAINSNGGSTYYPDTVKGRFTISRDNAKNTLYLQMSSLKSEDTALYYCAR
What are the official names of this protein?
Ig heavy chain V region RF.
Protein: RL25_RALPJ
Sequence: MKVVAFERSVQGTGASRRLRNSGKTPAIIYGAGAEPKLIELDHNALYHALKKEAFHSSILDIEVAGKVEKALLRDFQLHPFKQLVLHVDFQRVSAKEKIHVKVPLHFLNQETAPGVKLGHGIVNHILNDVEVSCLPADLPEFIEVDLGTLEIGQTLHIADLKLPKGVTILTHGGDENPAVANISVPAGEKSAAAEEGAAAAGEDKPAA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: SYV_BURMA
Sequence: MSDTTLAKSFEPQTIESQWGPEWEKRGYATPALDPSRPDFSIQLPPPNVTGTLHMGHAFNQTIMDGLVRYHRMLGHNTLWVPGTDHAGIATQIVVERQLDAQGVSRHDLGREKFVERVWEWKERSGSTITGQVRRIGASPDWSREYFTMNDKMSEAVREVFVRLYEQGLIYRGKRLVNWDPVLLTAVSDLEVVSEEENGHLWHIRYPLADGSGHLSVATTRPETMLGDVAVMVHPEDERYRHLVGRHVKLPLCEREIPIIADDYVDREFGTGVVKVTPAHDFNDYQVGLRHALAPIEILTLDAKINDNAPAAYRGLDRFDARKAIVDELDAQGLLESVKPHKLMVPRGDRTGVVIEPMLTDQWFVAMTKPAPQGTFHPGKSITEVSLEVVRRGEIKFVPENWTTTYYQWLENIQDWCISRQLWWGHQIPAWYGENGEIFVARNEEDARAQAAAKGYTGALKRDDDVLDTWFSSALVPFSSLGWPNETPEMKHFLPSSVLVTGFDIIFFWVARMVMMTTHFTGKVPFGTVYVHGLVRDAEGQKMSKSKGNTLDPIDIVDGIGLDALVAKRTTGLMNPRQAATIEKKTRKEFPDGIPAFGTDALRFTMASMATLGRNVNFDLARCEGYRNFCNKLWNATRFVLMNCEGHDCGFDKPEVCGAGDCGPGGYLDFSPADRWIVSLMQRVEADIAKGFADYRFDNIANAIYKFVWDEYCDWYLELAKVQIQNGTSEQQRATRRTLLRVLETVLRLAHPIIPFITEALWQKVAPLAGRYPAGKAEGEASLMVQAYPVAEPKKLDEACEQWAAELKAVVDACRNLRGEMNLSPATKVPLLAAGDAAQLQAFAPYVQALARLSEVRVLPDEAALDADAHGAPIAIVGGNKLVLKVEIDVAAERERLSKEIARLEGEIVKCNAKLGNEAFVAKAPPAVVAQEQKRLAEFQSTLTKLGAQLARLPA
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.