PharMolix/UniProtQA huggingface dataset:
Protein: LIPA4_HUMAN
Sequence: MCEVMPTINEGDRLGPPHGADADANFEQLMVNMLDEREKLLESLRESQETLAATQSRLQDAIHERDQLQRHLNSALPQEFATLTRELSMCREQLLEREEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRAALERVTTLEEQLAGAHQQVSALQQGAGVRDGAAEEEGTVELGPKRLWKEDTGRVEELQELLEKQNFELSQARERLVTLTTTVTELEEDLGTARRDLIKSEELSSKHQRDLREALAQKEDMEERITTLEKRYLAAQREATSIHDLNDKLENELANKESLHRQCEEKARHLQELLEVAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEEHLRQLEGQLEEKNQELARTAVQVRQREKMNEDHNKRLSDTVDRLLSESNERLQLHLKERMAALEEKNTLIQELESSQRQIEEQHHHKGRLSEEIEKLRQEVDQLKGRGGPFVDGVHSRSHMGSAADVRFSLGTTTHAPPGVHRRYSALREESAKLALPLTVTLRSPTWMRMSQGVCCNLEYHSSGTLCGSSGPLPVPEMIQEEKESTELRAEEIETRVTSGSMEALNLKQLRKRGSIPTSLTALSLASASPPLSGRSTPKLTSRSAAQDLDRMGVMTLPSDLRKHRRKLLSPVSREENREDKATIKCETSPPSSPRTLRLEKLGHPALSQEEGKSALEDQGSNPSSSNSSQDSLHKGAKRKGIKSSIGRLFGKKEKGRLIQLSRDGATGHVLLTDSEFSMQEPMVPAKLGTQAEKDRRLKKKHQLLEDARRKGMPFAQWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNALHRLKLRLAIQEMVSLTSPSAPPTSRTSSGNVWVTHEEMETLETSTKTDSEEGSWAQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELEKRREESQHEIKDVLVWTNDQVVHWVQSIGLRDYAGNLHESGVHGALLALDENFDHNTLALILQIPTQNTQARQVMEREFNNLLALGTDRKLDDGDDKVFRRAPSWRKRFRPREHHGRGGMLSASAETLPAGFRVSTLGTLQPPPAPPKKIMPEAHSHYLYGHMLSAFRD
What is the function of this protein?
May regulate the disassembly of focal adhesions.  May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity).
What are the official names of this protein?
Liprin-alpha-4, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4, PTPRF-interacting protein alpha-4.
What is the protein family that this protein belongs to?
Belongs to the liprin family. Liprin-alpha subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell surface. Note=Colocalizes with PTPRF at the cell surface.
Protein: FDHD_BURPS
Sequence: MSLSETVEPSGIVELAVRRRRGDAAETAVDRVGQEWPVALVFNGISHAVMMCTPRDLEAFAVGFAVSEGIVERGSDVKDIEVALHGAGPLPHAEVQLTVVQQAFAALKEKRRALAGRTGCGVCGIESIGLLDLVPQRLPDTGFLARLAPDAIARAARELPAHQALTRQTGGLHAAAWCDASGAIVHAFEDIGRHNALDKLIGTLTLTRADMANGFVFLSSRASYELVRKSARVGIPMVATISAPSSLAIEIARQAGLRLVSFCREAGYVDYGTA
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_BRUA2
Sequence: MSGKLTHIDQTGAANMVDVGSKDETERQAVAEGAVRMKPETLALILEGNAAKGDVIGTARLAGIMAAKRTSDLIPLCHPLMLTKVAVEIEPDENLPGLRVRALARLKGRTGVEMEALTAASVTCLTIYDMAKAVDRHMEIGSIRVIEKSGGKSGDWAVSDPALMR
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: HIS6_YERPY
Sequence: MLAKRIIPCLDVKDGQVVKGVQFRNHEIIGDIVPLAQRYAQEGADELVFYDITASSDGRVVDKSWVARVAEVIDIPFCVAGGIKSVEDASQILTFGADKISINSPALADPTLITRLADRYGVQCIVVGIDTWYDTESDSYQVYQFTGDEKRTKATTWQTEDWVKEIQLRGAGEIVLNMMNQDGVRNGYDLRQLQQMRAICHVPLIASGGAGTPDHFLEAFRDADVDGALAASVFHKQIINIGELKKYLSEQGVEIRVC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_ALKCK
Sequence: MEQQKALDLSFFEQSTIEVAKGLIGMHLVHELDGVTLIGRITETEAYLGVLDRACHSYGRRRTKRTAILYEEAGRCYTYTMHTHCLLNVVCEQKGQPEAVLIRAIEPISGVKEMERLRGKPHTSREFANGPGKLTKAMGITMADYGRLLTEPPLYFAKGDHTNASIVATKRIGIKGAGPCSHHPWRFIDGNSRAVSAYRP
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: MYB33_ARATH
Sequence: MSYTSTDSDHNESPAADDNGSDCRSRWDGHALKKGPWSSAEDDILIDYVNKHGEGNWNAVQKHTSLFRCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVELHAKMGNRWARMAAHLPGRTDNEIKNYWNTRIKRRQRAGLPLYPPEMHVEALEWSQEYAKSRVMGEDRRHQDFLQLGSCESNVFFDTLNFTDMVPGTFDLADMTAYKNMGNCASSPRYENFMTPTIPSSKRLWESELLYPGCSSTIKQEFSSPEQFRNTSPQTISKTCSFSVPCDVEHPLYGNRHSPVMIPDSHTPTDGIVPYSKPLYGAVKLELPSFQYSETTFDQWKKSSSPPHSDLLDPFDTYIQSPPPPTGGEESDLYSNFDTGLLDMLLLEAKIRNNSTKNNLYRSCASTIPSADLGQVTVSQTKSEEFDNSLKSFLVHSEMSTQNADETPPRQREKKRKPLLDITRPDVLLASSWLDHGLGIVKETGSMSDALAVLLGDDIGNDYMNMSVGASSGVGSCSWSNMPPVCQMTELP
What is the function of this protein?
Transcriptional activator of alpha-amylase expression that binds to 5'-CAACTGTC-3' motif in target gene promoter (PubMed:11743113).  Positive regulator of abscisic acid (ABA) responses leading to growth arrest during seed germination (PubMed:17217461).  In vegetative tissues, inhibits growth by reducing cell proliferation.  Promotes the expression of aleurone-related genes (e. g.  CP1, CP, GASA1, BXL1 and BXL2) in seeds.  Together with MYB65 and MYB101, promotes the programmed cell death (PCD) the vacuolation of protein storage vacuoles (PSVs) in the aleurone layers during seed germination (PubMed:20699403).  Binds to a GARE site (GA-response element) in the LEAFY promoter, essential for its gibberellic acid (GA)-mediated induction (PubMed:15226253).  Together with MYB65, facilitates anther and tapetum development (PubMed:15722475).
What are the official names of this protein?
Transcription factor MYB33, Myb-related protein 33, AtMYB33.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1025_OCEIH
Sequence: MKILMVTGYKPMELNIFKEDDSRIQFIKASIEKRVREFLEEGLEWVIISGQMGVELWAADVVMELKEEYPVQLGVFPPFENQDGRWPDALKEKYEELTMTADFFKPIYKGDYQGPYQFRTKDMWLIDKSDACLLLMDEEFPGSTKYFYDTLQKTAKDYPVFTITPQDIDDVVEDLRMQDPHYWD
What are the official names of this protein?
UPF0398 protein OB1025.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: MURA_PSYCK
Sequence: MDQFLITGSSRIAGEVTISGAKNAALPLLAAMILAETPTTLHNVPSLQDVRTLIELIGGMGIKIQKQGDTVTCDTKSIDNFYAPYDLVKTMRASILVLGPLLARFGEAEVSLPGGCAIGSRPVDQHLKAFEAMGASITVENGYVIAQAPKGGKLLGCKFSFDMVTVGGTENVIMAAALAKGTTVLGNCALEPEVVDLANMLVAMGAKISGIGTATMTIEGVERLHGCEYSVVPDRIETGSYLAGALMTHGDVLTKNTSALLLTPVLEKFEDMGAIITTGDDWIRAQMKGRPKAVDIRTQPHPGFPTDMQAQVMAIACLADGTSTFIENIFENRYMHVPELNRLGASIQVDGHTAVVKGVECFTAAPVMATDLRASMSLVMAAATAEGESLIDRIYHIDRGYEHVEDKLRALGVNIERINSND
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CIAO1_PENRW
Sequence: MSPKVTITHLSDLTPPSQERTWLTAPHPTLPLVATCSSDKTIRVYSLTNFTLLSTITGGHKRSVRTAAWKPHMTGESVLATGSFDATVGIWRRWDSYGQEGDAGMGMSSGDKQIPTDISTAASNGTGTDTADREEDEEEWRFAVLLDGHDSEVKSVSWSASGMLLATCSRDKSIWIWEDLDDGDNNFETVAVMQEHGGDVKCVSWHPSEECLASGSYDDTIRLWREDLDDWGQVACIKGHGGTVWFLDWEGEETEGNWSGPVADSVSESALSALQAQWRSQRALSGPRLLSCSDDRTVRVWRRQPKESQQTGPLSSATTGIPSIIRPTGTDEVWEEDAVLPRAHELPVYAVAWSKRTGLVASTGADGRIALYEERFVTREQEQEQQADSDAMDTTSGDVLRTEWVLVGVQDGAHGIYEINHVAWAKRADRRPGGEEEVLVSTADDGSVKVWTLTR
What is the function of this protein?
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery.  Required for the maturation of extramitochondrial Fe/S proteins.
What are the official names of this protein?
Probable cytosolic iron-sulfur protein assembly protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CIA1 family.
Protein: PUR9_PSEFS
Sequence: MTDQTTRLPIRRALISVSDKTGILEFARELEALGVEILSTGGTFKLLQDNGVAAVEVADYTGFAEMMDGRVKTLHPKIHGGILGRRGIDDAIMTEHGIKPIDLVAVNLYPFEATINKPGCDLPTAIENIDIGGPTMVRSAAKNHKDVAIVVNASDYAQVLESLKAGGLTYAQRFDLMLKAFEHTAAYDGMIANYMGTVNQAAETLSTEGRSQFPRTFNSQFIKAQEMRYGENPHQSAAFYVEAKPAEVGIATATQLQGKELSYNNVADTDAALECVKSFVKPACVIVKHANPCGVAVSPDAEGGIRQAYELAYATDTESAFGGIIAFNRELDAETAKAIVERQFVEVIIAPSVSEEARAIVAAKANVRLLACGEWSADRAAAWDYKRVNGGLLVQSRDIGMIGSEDLKVVTKRAPTEQEINDLIFAWKVAKYVKSNAIVYAKNRQTIGVGAGQMSRVNSARIAAIKAEHAGLQVVGSVMASDAFFPFRDGLDNAAKAGVTAVIQPGGSMRDAEVIAAADEAGIAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: CALM_ORYLA
Sequence: EQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFV
What is the function of this protein?
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding.  Calcium-binding is required for the activation of calmodulin.  Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
What are the official names of this protein?
Calmodulin-A, CaM A.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: SANT_PLAF7
Sequence: MNRILSVTLCLFFIYLYIYKTYGKVKNTDEGLSNIYGAKYYLRSGLFNEKNGKGQKYEDLEEEKEGENDDEEDSNSEESNNDEENELIKGQEGVEQETHGSEDEVSNGREDKVSNGGEDEVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGREDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGREDKVSNGGEDEVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDEVSNGREDKGGAGTDGELSHNSESHTKNKKSKNSIINMLIGM
What is the function of this protein?
S antigens are soluble heat-stable proteins present in the sera of some infected individuals.
What are the official names of this protein?
S-antigen protein.
What are the subcellular locations of this protein?
Parasitophorous vacuole. Note=Localizes to the cell periphery in early schizonts and then to the parasitophorous vacuole in late schizonts. Following schizont rupture, the S-antigen is released in host sera.
Protein: MSH3_YEAS7
Sequence: MAGQPTISRFFKKAVKSELTHKQEQEVAVGNGAGSESICLDTDEEDNLSSVASTTVTNDSFPLKGSVSSKNSKNSEKTSGTSTTFNDIDFAKKLDRIMKRRSDENVEAEDDEEEGEEDFVKKKARKSPTAKLTPLDKQVKDLKMHHRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKLTIDESNPQDCNHRQFAYCSFPDVRLNVHLERLVHHNLKVAVVEQAETSAIKKHDPGASKSSVFERKISNVFTKATFGVNSTFVLRGKRILGDTNSIWALSRDVHQGKVAKYSLISVNLNNGEVVYDEFEEPNLADEKLQIRIKYLQPIEVLVNTDDLPLHVAKFFKDISCPLIHKQEYDLEDHVVQAIKVMNEKIQLSPSLIRLVSKLYSHMVEYNNEQVMLIPSIYSPFASKIHMLLDPNSLQSLDIFTHDGGKGSLFWLLDHTRTSFGLRMLREWILKPLVDVHQIEERLDAIECITSEINNSIFFESLNQMLNHTPDLLRTLNRIMYGTTSRKEVYFYLKQITSFVDHFKMHQSYLSEHFKSSDGRIGKQSPLLFRLFSELNELLSTTQLPHFLTMINVSAVMEKNSDKQVMDFFNLNNYDCSEGIIKIQRESESVRSQLKEELAEIRKYLKRPYLNFRDEVDYLIEVKNSQIKDLPDDWIKVNNTKMVSRFTTPRTQKLTQKLEYYKDLLIRESELQYKEFLNKITAEYTELRKITLNLAQYDCILSLAATSCNVNYVRPTFVNGQQAIIAKNARNPIIESLDVHYVPNDIMMSPENGKINIITGPNMGGKSSYIRQVALLTIMAQIGSFVPAEEIRLSIFENVLTRIGAHDDIINGDSTFKVEMLDILHILKNCNKRSLLLLDEVGRGTGTHDGIAISYALIKYFSELSDCPLILFTTHFPMLGEIKSPLIRNYHMDYVEEQKTGEDWMSVIFLYKLKKGLTYNSYGMNVAKLARLDKDIINRAFSISEELRKESINEDALKLFSSLKRILKSDNITATDKLAKLLSLDIH
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  MSH3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with either the MutL alpha or MutL beta heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  MutS beta also has a role in regulation of heteroduplex formation during mitotic and meiotic recombination.  MutS beta binds to DNA flap structures predicted to form during recombination, and is required for 3' non-homologous tail removal (NHTR).  MutS beta-binding alters the DNA conformation of its substrate at the ds/ssDNA junction and may facilitate its recognition and/or cleavage by the downstream nucleotide excision repair (NER) RAD1-RAD10 endonuclease.  ATP binding and hydrolysis play a pivotal role in MMR and NHTR (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MSH3, Mismatch-binding protein, MBP, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HPRK_STRT2
Sequence: MTVTVKMLVDKLKLKVVYGNEELLAKAITTADISRPGLEMVGYFDYYSPERLQLVGMKEWTYLKTMTANNRYSVFANIFREETPAVIVARGLEIPEEMLQAAKENGVAVLQGRNSTSSLSGDMSWYLNSQLAERTSVHGVLVDIYGMGVLIQGDSGIGKSETALELVKRGHRLVADDRVDVYAKDEGTLWGEPAEILLHLLEIRGVGIIDVMSLYGASAVRDSSQVQLCICLEHFENDEVFDRLGNSNEEIELQGVKIPRIRIPVKTGRNVSVVIEAAAMNYRAKQMGYDATKTFKDRLTDLISKNGED
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: NUOH_GEOSW
Sequence: MMEQLLNSAPSWTNLVIFFGLGLALLFAVLAFVTYGILAERKVMGFMQGRYGPNQVGGRWGLLQTVADVLKLLLKEDTIPKAADKPLFILAPIIAFAPAFMVLATLPFTDAFQFADIGVGLLYYIAVSGLTTIGVVAGGWASNNKYALIGAMRAAAQMISYEIPLVVSVLGVVLLTGSLNLNDIVEAQKDVWYIFIQPIAFIVFFIAAVAELNRTPFDLPEAESELVAGFHVEYSGFRWAFFMLSEYVYLFAMAALTTILFLGGWHPVMFLDFIPGAVWFALKFSIVVFVLIWFRVTFPRLRADQLMELGWKVLFPVALLNIFVTALIQELFF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: R10A_ORYSJ
Sequence: MSKLQSEVLKEAISQVVGESKEKGRKFTETVELQIGLKNYDPQKDKRFSGSVKLPHIPRPKMKVCMLGDAQHVEEAEKIGLDYMDVEALKKMNKNKKLVKKLAKKYHAFLASEAIIKQIPRLLGPGLNKAGKFPTLVTHQESLESKVNETKATVKFQLKKVLCMGVAVGNLSMEEKQIQQNIQMSVNFLVSLLKKNWQNVRCLYIKSTMGKPIRVF
What are the official names of this protein?
60S ribosomal protein L10a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: MTND_XYLFT
Sequence: MSRLRIFDDHTPDTPFFVSKEQAQITAELHKIGITFERWEATQAIEPGATAEQVMAAYRTDIDRLIATHGFKTVDVISIAPDNAKREEMRAKFLEEHFHKEDEVRFFVAGSGLFTVHSGNKVYEIECVKNDLIAIPDGTLHWFDMGAAPYFVAIRFFTEPDGWVGHFTGTDIAQRFPRYIPEGCQSAH
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: SECA_CHLAD
Sequence: MLNFFRRLLGDSNEKEIRRLQPIVEEINRLGPEFARLSDAELRAKTDEFRQRLADGETLDDILPEAFATVREAAARTIGLRHYDVQLIGGIVLHQGKIAEMKTGEGKTLVATLPLYLNALEGKGVHLVTVNDYLAKVGAGWMGPIYHFLGLSVGFIAHDQSALYDPDYIDPNANPEDQRLVHWRPCTRREAYLADITYGTNNEFGFDYLRDNMAYDKSQLVQRELHYAIVDEVDNILIDEARTPLIISGPAQKSSDLYRQMAKLVRQLRRSSVTAKQVKEEGLEPDGDFFVDERTKSIYLSEKGIEKLEKLLNIPPGESLFDPEHYEKTHYVENALKAQFIYQRDRDYMVTPNGEVVIIDEFTGRAMPGRRWSDGLHQAIEAKEGVPIKNENVTLATITFQNYFRMYKKLAGMTGTAYTEREEFAKIYNLDVVVIPTHKPMIRKDLPDQIYATEEAKFRAVLREVQEMHEIGRPVLIGTTSVETSERLSAMLKQAGIPHNVLNAKHHEREAAIVAQAGRKGAVTVATNMAGRGTDILLGGNPDGLVEEFLRKEGLTLETATPEQKRAAWEKAKALTEAEGEEVRQLGGLHVIGTERHEARRIDNQLRGRAGRQGDPGSSRFFLSLEDELLRRFGPVERIKGLMERFVDSDVPLQAGLLDRTIESAQTRVEGYNFDIRKHTVEFDDVMNKQRQIIYADRKAILDEADMRERVLDLMAEEIQRQIDEHLSDGVDEFGLTELLRVYRRIDPTLPATVTAETLKGKTKEEIEQFLLDHLETTYAEREKAIGPEVMRTVERRVMLGAIDRQWVDYLTAMDELRQNILLQAYAQKDPLVEFKRESFRMFDELKANIAHDIVYNIIPASFQYEAYLRQIAEEQARRLATAQIAGGSSEVEQTRKPQRRTVQQIGRNDPCPCGSGKKFKHCHLGREHELAAFMNNAPATTPKVEPQPVKPAIAEEAAKIKAAIDNGTLPAASPKTPRGRQPQAVPRGKKR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: RLMN_ACTPJ
Sequence: MSEQTQTCASEIQATNVAVQHPKSEKINLMNLTRQEMRELFAEMGEKPFRADQLMKWIYHFGEDNFDNMSNINKVLREKLKQIAEIKAPEVSVEQRSSDGTIKWAMQVGDQQIETVYIPEDDRATLCVSSQVGCALACKFCSTAQQGFNRNLTVSEIIGQVWRASKIIGNFGVTGVRPITNVVMMGMGEPLLNLNNVIPAMEIMLDDFAYGLSKRRVTLSTAGVVPALDIMREKIDVALAISLHAPNDELRDEIMPINKKYNIKMLMDSVHKYLEVSNANHGKVTIEYVLLDHVNDGTEHAHQLAEVLKNTPCKINLIPWNPFPEAPYGKSSNSRVDRFQKTLMEYGFTVIVRKTRGDDIDAACGQLAGDVIDRTKRTMEKRKFGKGIAVQNH
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LA_BOVIN
Sequence: MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDAALDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFAVFDSIESAKKFVETPGQKYKDTDLLILFKEDYFTKKNEERKQNKMEAKLRAKQEQEEKQKLAENAEMKSLEEKIGCLLKFSGDLDDQTCREDLHTLFSNHGEIKWIHFVRGAKEGIILFKEKAKEALDKAKEANNGNLQLRNKEVTWEVLEGDVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQAGSAKGKVQFQGKKTKFDSDDERDENGASRAVKRAREETDKEPPSKQQKTENGAGDQ
What is the function of this protein?
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
What are the official names of this protein?
Lupus La protein homolog, La autoantigen homolog, La ribonucleoprotein.
What are the subcellular locations of this protein?
Nucleus.
Protein: AB1IP_MOUSE
Sequence: MGESNEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPREEFNYTVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESSQNQDRFALLRASDGQGTASGGYGASAAAIDVSHHEEALPPPPVEPMLDLLPPPPPPPPPELLSKEEEEAKAKADKIKLALEKLKEAKVKKLVVKVHMDDSSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERVFEDHENVVEVLSDWTRDTENKVLFLEKEERYAVFKNPQNFYLDNKGKKENKETNEKMNAKNKEYLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGIQCKMKYKAPTDHCFVLKHPQIQKESQYIKYLCCDDARTLSQWVMGIRIAKYGKTLYDNYQRAVARAGLASRWTNLGTVGTPMPAQPSTVSSGLKTGTSQPNGQMPQAIPSAGPPLQEAQTQIETTKDEKQGLGNHSPGATRENHRPKSSLPPPPPPVRRSSDTCGSPALPSKVKGPGTCTFPHPPENFLPPPPPPPPEEDNSGLLPPPPPPPYLEEPPDFVPPPPPPAAVEDSALPPPPPPPPCLSQEITKSSPLPPKKPLVPPKRQENQGLPGAPGNSEQDFMSDLMKALQKKRGNIP
What is the function of this protein?
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling.  Suppresses insulin-induced promoter activities through AP1 and SRE.  Mediates Rap1-induced adhesion (By similarity).
What are the official names of this protein?
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, APBB1-interacting protein 1, Proline-rich EVH1 ligand 1, PREL-1, Proline-rich protein 48.
What is the protein family that this protein belongs to?
Belongs to the MRL family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases.
Protein: RSD_SHIBS
Sequence: MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQKVLSDIGEALEARFVLEDKLILLVLDAARVKHPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.