PharMolix/UniProtQA huggingface dataset:
Protein: DHE2_PEPAS
Sequence: MTDTLNPLVAAQEKVRIACEKLGCDPAVYELLKEPQRVIEISIPVKMDDGTVKVFKGWRSAHSSAVGPSKGGVRFHPNVNMDEVKALSLWMTFKGGALGLPYGGGKGGICVDPAELSERELEQLSRGWVRGLYKYLGDRIDIPAPDVNTNGQIMSWFVDEYVKLNGERMDIGTFTGKPVAFGGSEGRNEATGFGVAVVVRESAKRFGIKMEDAKIAVQGFGNVGTFTVKNIERQGGKVCAIAEWDRNEGNYALYNENGIDFKELLAYKEANKTLIGFPGAERITDEEFWTKEYDIIVPAALENVITGERAKTINAKLVCEAANGPTTPEGDKVLTERGINLTPDILTNSGGVLVSYYEWVQNQYGYYWTEAEVEEKQEADMMKAIKGVFAVADEYNVTLREAVYMYAIKSIDVAMKLRGWY
What are the official names of this protein?
NAD-specific glutamate dehydrogenase, NAD-GDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: NCEH1_PONAB
Sequence: MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVSNLIHYLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAKIRYYDELCTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDSAGGSLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNTPILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAALRARLNWTSLLPASFTKNYKPVVQTTGNARIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKRLETAGVEVTLDHFEDGFHGCMIFTSRPTNFSVGIRTRNSYIKWLDQNL
What is the function of this protein?
Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity).  May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity).  Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity).
What are the official names of this protein?
Neutral cholesterol ester hydrolase 1, NCEH, Acetylalkylglycerol acetylhydrolase, 2-acetyl MAGE hydrolase, Arylacetamide deacetylase-like 1.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Microsome.
Protein: FEV_RAT
Sequence: MRQSGTSQPLLINMYLPDPVGDGLFKEGKSPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPNATAAAAATAALYPTPGLQPPPGPFGAVAAASHLGGHYH
What is the function of this protein?
Functions as a transcriptional regulator.  May function as a transcriptional repressor.  Functions in the differentiation and the maintenance of the central serotonergic neurons.  May play a role in cell growth.
What are the official names of this protein?
Protein FEV, PC12 ETS domain-containing transcription factor 1, PC12 ETS factor 1, Pet-1.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RR15_CHAGL
Sequence: MLTNQLNSESKNINKIGSIEEQVVSLTQRVKFISNHLKINKKDYSSQRGLRKILGKRKRLLTYLYKKDFLKYKFVIQSLGIRSLK
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YHAM_BACVZ
Sequence: MAKGIMLHEVGEQVDQYFLIKSSTKGIASNGKPFLTLMLQDQSGDIEAKLWDAKPTDETTYAAQTIVKVIGDVHHYRGRNQLKLRNIRPAGENENVSIDDFLETAPIPKNEMMETVTQYIFEMKNPNIQRITRHLVKKYAAEFMDYPAAAKNHHEFVSGLAYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTTYTVEGNLLGHISIMVTELSKAAEELQIDAEEVLILKHLILSHHGKAEWGSPKPPMVKEAEILHYIDNLDAKMIMMDRALERVKPGEYTERVFALENRSFYKPTFHQ
What is the function of this protein?
Shows a 3'-5' exoribonuclease activity.
What are the official names of this protein?
3'-5' exoribonuclease YhaM.
What is the protein family that this protein belongs to?
Belongs to the YhaM family.
Protein: MAON_MOUSE
Sequence: MGAALGTGARLTSVPRIACSSLRRQAPSAPAQGCHSKSGPPRPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYENQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHIATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVRGEEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNRLSNHVFVFQGAGEAAMGIAHLLVMALEKEGIPKTEAIKKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIVFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGRTFTPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAVKVLDYAYKHNLASYYPEPKDKEAFVKSLIYTPDYDSFSLDTYSWPKEAMSVQKV
What are the official names of this protein?
NADP-dependent malic enzyme, mitochondrial, NADP-ME, Malic enzyme 3.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: VKT53_CYRHA
Sequence: MGTARFLRAVLLLSVLLMVTFPALLSAEHHDGRVDICRLPSDSGDCLRFFEMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA
What is the function of this protein?
Dual-function toxin that inhibits both serine proteases and voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type U15-theraphotoxin-Hhn1a, U15-TRTX-Hhn1a, Kunitz-type serine protease inhibitor HNTX-853.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 03 (sub-Kunitz) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: THIO_MYCTO
Sequence: MTDSEKSATIKVTDASFATDVLSSNKPVLVDFWATWCGPCKMVAPVLEEIATERATDLTVAKLDVDTNPETARNFQVVSIPTLILFKDGQPVKRIVGAKGKAALLRELSDVVPNLN
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx, MPT46.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: RBSA_STRA5
Sequence: MKIDMRNISKSFGTNKVLEKIDLELQSGQIHALMGENGAGKSTLMNILTGLFPASTGTIYIDGEERTFSNPQEAEEFGISFIHQEMNTWPEMTVLENLFLGREIKTTFGLLNQKLMRQKALETFKRLGVTIPLDIPIGNLSVGQQQMIEIAKSLLNQLSILVMDEPTAALTDRETENLFRVIRGLKQEGVGVVYISHRMEEIFKITDFVTVMRDGVIVDTKETSLTNSDELVKKMVGRKLEDYYPEKHSEIGPVAFEVSNLCGDNFEDVSFYVRKGEILGFSGLMGAGRTEVMRTIFGIDKKKSGKVKIDDQEITITTPSQAIKQGIGFLTENRKDEGLILDFNIKDNMTLPSTKDFSKHGFFDEKTSTTFVQQLINRLYIKSGRPDLEVGNLSGGNQQKVVLAKWIGIAPKVLILDEPTRGVDVGAKREIYQLMNELADRGVPIVMVSSDLPEILGVSDRIMVMHEGRISGELSRKEADQEKVMQLATGGK
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MURE_PASMU
Sequence: MRRLTALLGQVELAPNIELTEMILDSRAVKQGCLFVALQGHQVDGRQYIPQAIAKGASAVLAETEDAQQHLSTKIEQGVPIISFYQLGSHLSALAGLFYDNPSHKLTLVGVTGTNGKTTISQLLAQWTTLLGHRSAVMGTIGNGLLGQVKEATNTTGSAVEVQASLADFVKRGADFAAIEVSSHGLVQHRVEALAFDVAIFTNLSRDHLDYHQSMENYALAKKRLFTELNSRHQIINADDSVGQTWLQEQPNAVAVSCQTDFKPHQARWLKATAIQFSQKGARIQFESSWGKGELHSALIGQFNVSNLLLVFATLLSLGYDIEKLMKTVPQLTGVCGRMERLSASNQPTAIVDYAHTPDALEKALQAARLHCQGKLWCVFGCGGDRDRGKRPIMAKIAEQFADHVIVTDDNPRTESAAQIVQDILAGFEHPQHVEVCHARDQAIIQALQKADSDDVVLIAGKGHEDYQIIGTQKQHFSDQETVQQYFKVNHHHA
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPZ_PRIM1
Sequence: MQDLQHVFPRLRSYILYLLALYVLGWGFTSYKAVFAGLILGTALSLYNLWNLVRKFEQFGQALDEGKKPRSIGTVVRFATAALAVVITISYPKTFHIISVVVGLMTYYVVIIIDLVVQNMRRR
What is the function of this protein?
A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex.
What are the official names of this protein?
ATP synthase protein I.
What is the protein family that this protein belongs to?
Belongs to the bacterial AtpI family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PCKA_HAEIE
Sequence: MTDLNKVVKELEALGIYDVKEVVYNPSYEQLFEEETKPGLEGFEKGTLTTTGAVAVDTGIFTGRSPKDKYIVLDEKTKDTVWWTSETAKNDNKPMNQATWQSLKDLVTNQLSRKRLFVVDGFCGASEHDRIAVRIVTEVAWQAHFVKNMFIRPTEEQLKNFEPDFVVMNGSKVTNPNWKEQGLNSENFVAFNLTERIQLIGGTWYGGEMKKGMFSIMNYFLPLKGVGAMHCSANVGKDGDVAIFFGLSGTGKTTLSTDPKRELIGDDEHGWDDVGIFNFEGGCYAKTIHLSEENEPDIYRAIRRDALLENVVVRADGSVDFDDGSKTENTRVSYPIYHIDNIVKPVSRAGHATKVIFLTADAFGVLPPVSKLTPEQTKYYFLSGFTAKLAGTERGITEPTPTFSACFGAAFLTLHPTQYAEVLVKRMQAAGAEAYLVNTGWNGTGKRISIKDTRGIIDAILDGSIEKAEMGELPIFNLAIPKALLGVDSAILDPRDTYADKAQWQSKAEDLAGRFVKNFVKYATNEEGKALIAAGPKA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL2_CEREL
Sequence: MYKIQLLSCIALTLALVANGAPTSSSTGNTMKEVKSLLLDLQLLLEKVKNPENLKLSKMHTFNFFMPKVNATELKHLNCLLEELKLLEDVLSLSPSKNLNPKEIKDSMDEIKDLMDNIKRIVLELQGSETSFKCEYDAATVKAVEFLNKWITFCQRIYSTMT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLCD1_SACS2
Sequence: MKAIIVKPPNAGVQVKDVDEKKLDSYGKIKIRTIYNGICGTDREIVNGKLTLSTLPKGKDFLVLGHEAIGVVEESYHGFSQGDLVMPVNRRGCGICRNCLVGRPDFCETGEFGEAGIHKMDGFMREWWYDDPKYLVKIPKSIEDIGILAQPLADIEKSIEEILEVQKRVPVWTCDDGTLNCRKVLVVGTGPIGVLFTLLFRTYGLEVWMANRREPTEVEQTVIEETKTNYYNSSNGYDKLKDSVGKFDVIIDATGADVNILGNVIPLLGRNGVLGLFGFSTSGSVPLDYKTLQEIVHTNKTIIGLVNGQKPHFQQAVVHLASWKTLYPKAAKMLITKTVSINDEKELLKVLREKEHGEIKIRILWE
What is the function of this protein?
Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone.  Can utilize both NAD(+) and NADP(+) as electron acceptor.  Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
What are the official names of this protein?
Glucose 1-dehydrogenase 1, GDH 1, GlcDH 1.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
Protein: ATPB1_CHLL3
Sequence: MQEGKISQIIGPVVDVDFPEGQLPSILDALTITRPDGSRLVLETQQHLGEERVRTVAMESTDGLIRGLSVANTGRPIQAPVGEGVLGRMLNVVGDPIDGRGPVNATKTYSIHRSAPKFEDLSTKAEMFETGIKVIDLLEPYSRGGKTGLFGGAGVGKTVLIMELINNIAKQQSGYSVFAGVGERTREGNDLWHEMMESGVIDKTALVFGQMNEPPGARARVALTGLSIAEYFRDEEHRDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGELQDRITSTKNGSVTSVQAIYVPADDLTDPAPATAFAHLDATTVLSRQIAELGIYPAVDPLDSTSRILDPNVIGDDHYDTAQSVKQILQRYKDLQDIIAILGMDELSDEDKLVVARARKVQRFLSQPFFVAEAFTGLAGKYVKLEDSIKGFKEIIAGKHDNLPEGAFYLVGTIEEAIEKAKTL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta 1, ATP synthase F1 sector subunit beta 1, F-ATPase subunit beta 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MOBA_OPITP
Sequence: MSANASALAGAVLAGGESRRMGRDKARLRLRGETLAQRQVRVLREAGAEPVVIVRRAEQRMSVRAVEQVCDEFVGAGPLAGVQAALKAAAAAGARWIAVLAVDMPAIEAAWFGDLRRACRKGKGAVVRHADGFEPLAAIYPINALATAERRLRRGERSMQRFVAALVRQRKMRVVALPEEERWRVANWNRPEDRDRERRKHA
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Probable molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y139_WOLSU
Sequence: MKILYYDCFSGISGDMHLGALVDLGVELEYLQKELAKLPLEGEYELSATTVSKSGIRATQVKVKLREHHHHDHRTFGNIRAMILSSALSLRIKERALKMFQKIAEAESRIHAKPLEQVAFHEVGAIDSIIDIVGSAIGLEALGVEKIYASRIELGGGFVRCAHGLLPVPAPATLEILQGLPIGLHGVPFEATTPTGAAILACNVDSFSGSLPLSPQKIGYGAGEREGVDIPNILRLILADEPVQPSPKEVLLETNIDDMSPEHLAYAVERLFEAGALDVYMTPITTKKNRLATKLSILSLLDKERELTQILFQETSSIGLRRLEVEKIALARRFIQVPTPWGEVSVKLSMQGEKVVRYKAEYEECRRLAMTHSVPLHTLYLAIDKAVESCLNDTNH
What are the official names of this protein?
Putative nickel insertion protein.
What is the protein family that this protein belongs to?
Belongs to the LarC family.
Protein: TT23L_MOUSE
Sequence: MARAPAQARGSRGLNCLARSQQTGIPAQETDDLFSTCYCEETEEDTAHQEAGMTVDCLSIPKKKLAQSQKKINQFINSKMSTKANKELIRCFILSQIVFGKEHWKCAQALANLAYGYLTLRGLPAQAKKHAEKARNTLLTWKRNTTSDKDKKEILETLVRLYYTLGVAWLLQNHGKQAYIHLQKAERNMKELKELNNGNICGIQVSEKDLTIALGRASLAMHRMNLALAYFEKAICDVILDKGHNTSELISLYEEIAQIEQLRKNHKQAIQYLQQAYSICVSSFSEVSPQTAEASALLAKAYAMSGASEYRDAVEIYFIRSISTYQTLGSEDYETLTAIEDFCTWLIENGEKQEAYRLLKSTLNSGNFGDCGKKVAETFYNMGSICFAKGELGEAIELLSKCLMIQSLVYGSEHIKSIETKSLLSLLQRWRLKETLEKNRKEASGGETFQKTVITLLQ
What are the official names of this protein?
Tetratricopeptide repeat protein 23-like.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Exhibits dynamic subcellular localization during the cell cycle. In prophase cells, detected on split centrosomes. Translocates to the mitotic spindles during metaphase and early anaphase, then to the midbody and cleavage furrow in late anaphase.
Protein: TRM2B_PONAB
Sequence: MAGLFFKPGLLPWYARNPPGWSQLFLGTVCKGDFTRVIATKCQKGQKSQKKPSHLGPLDGSWQERLADVVTPLWRLSYEEQLKVKFAAQKKILQRLESYIQMLNGVSVTTAVPKSERLSCLLHPIIPSPVINGYRNKSTFSVNRGPDGNPKTVGFYLGTWRDGNMVCVQSNHLKNIPEKHSQVAQYYEVFLRQSPLEPCLVFHEGGYWRELTVRTNSQGHTMAIITFHPQNLSQEEFHVQKEIVKEFFIRGPGAACDLTSLYFQESTMTRCSHQQSPYQLLFGEPYIFEELLSLKIRISPDAFFQINTAGAEMLYRTVGELTGVNSDTILLDICCGTGVIGLSLSQHTSRVLGIELVEQAVEDARWTAAFNGITNSEFHTGRAEKILPGLLKSKEDGQSIVAVVNPARAGLHYKVIQAIRNFRAIHTLVFVSCKLHGESTRNVIELCCPPDPAKKLLGEPFVLQQVVPVDLFPHTPHCELVLLFTR
What is the function of this protein?
Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA.  Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs.  Specifically methylates the uridine in position 429 of 12S rRNA (m5U429).  Does not affect RNA stability or mitochondrial translation.
What are the official names of this protein?
tRNA (uracil-5-)-methyltransferase homolog B, TRM2 homolog B, rRNA (uracil-5-)-methyltransferase TRMT2B.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RTN4R_HUMAN
Sequence: MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC
What is the function of this protein?
Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207).  Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262).  Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity).  Can also bind heparin (By similarity).  Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574).  Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200).  Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071).  Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system.  Plays a role in postnatal brain development.  Required for normal axon migration across the brain midline and normal formation of the corpus callosum.  Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG.  Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development.  Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).
What are the official names of this protein?
Reticulon-4 receptor, Nogo receptor, NgR, Nogo-66 receptor.
What is the protein family that this protein belongs to?
Belongs to the Nogo receptor family.
What are the subcellular locations of this protein?
Cell membrane; Lipid- anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses.
Protein: SYE1_HELPG
Sequence: MSLIVTRFAPSPTGYLHIGGLRTAIFNYLFARANQGKFFLRIEDTDLSRNSIEAANAIIEAFKWVGLEYDGEILYQSKRFEIYKEYIQKLLDEDKAYYCYMSKDELDALREEQKARKETPRYDNRYRDFKGTPPKGIEPVVRIKVPQNEVIGFNDGVKGEVKVNTNELDDFIIARSDGTPTYNFVVIVDDALMGITDVIRGDDHLSNTPKQIVLYKALNFKIPNFFHVPMILNEEGQKLSKRHGATNVMDYQEMGYLKEALVNFLVRLGWSYQDKEIFSMQELLECFDPKDLNSSPSCFSWHKLNWLNAHYLKNQSAQKLLELLKPFSFSDLSHLNPAQLDRLLDALKERSQTLKELALKIDEVLIAPVEYEEKVFKKLNQALIMPLLEKFKLELKEANFNDESALENAMHKIIEEEKIKAGSFMQPLRLALLGKGGGIGLKEALFILGKTESVKRIENFLKN
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN479_HUMAN
Sequence: MAKRPGPPGSREMGLLTFRDIAIEFSLEEWQCLDCAQRNLYRDVMLENYRNLVSLGIAVSKPDLITCLEQNKESQNIKRNEMVAKHPVTRSHFTQDLQPEQGIKDSLQKVIPRTYGKCGHEKLQFKKCCKSVGEYEVHKGGYSEVNQCLSTTQNKIFQTHKYVKVFGKFSNSNRDKTRYTGNKHFKCNKYGKSFCMLSHLNQHQVIHTREKSYKCKECGKSFNCSSNHTTHKIIHTGEKPYRCEECGKAFSWSANLTRHKRTHTGEKPYTCEECGQAFRRSSALTNHKRIHTGERPYKCEECGKAFSVSSTLTDHKRIHTGEKPCRCEECGKAFSWSSNLTRHKRIHTREKPYACEECGQAFSLSSNLMRHRRIHTGEKPYTCEECGQDFRRSSALTIHKRIHTGERPYKCEECGKVFSLSSTLTDHKRIHTGERPYKCEECGKAFSLSSTLTDHKRIHTGERPYTCEECGKAFNCSSTLMQHKRIHTGEKPYKCEECEQAFKWHSSLAKHKIIHTGEKPYKCE
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 479, Zinc finger protein Kr19, HKr19.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL30_MICLC
Sequence: MFESTRKNIQPSDATLVITQTRGVTGSKQNHRDTLRSLGLKRIGHQVTRKADAVTVGMVNTVPHLVSVEEVNNG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: GGR_SULAC
Sequence: MKELKYDVLIIGGGFAGSSAAYQLSRRGLKILLVDSKPWNRIGDKPCGDAVSKAHFDKLGMPYPKGEELENKINGIKLYSPDMQTVWTVNGEGFELNAPLYNQRVLKEAQDRGVEIWDLTTAMKPIFEDGYVKGAVLFNRRTNEELTVYSKVVVEATGYSRSFRSKLPPELPITEDLDDKDADVAYREVLLTKEDIEDHDYLRIFIDQETSPGGYWWYFPKGKNKVNVGLGIQGGMGYPSIHEYYKKYLDKYAPDVDKSKLLVKGGALVPTRRPLYTMAWNGIIVIGDSGFTVNPVHGGGKGSAMISGYCAAKAILSAFETGDFSASGLWDMNICYVNEYGAKQASLDIFRRFLQKLSNDDINYGMKKKIIKEEDLLEASEKGDLHLSVADKAMRVISGLGRPSLLFKLKAVAESMKKIKELYLNYPRSPSSLGSWRREVDNVLTEFNKSLS
What is the function of this protein?
Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids.  Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.  Is not active with NADPH or NADH as an electron donor; the physiological reducing agent is unknown.  Is also active on the more upstream precursors of membrane lipid biosynthesis, catalyzing the complete reduction of 3-O-geranylgeranylglyceryl phosphate (GGGP) to 3-O-phytanylglyceryl phosphate, and the partial reduction of geranylgeranyl diphosphate (GGPP) to phytyl diphosphate, thus reducing three of four GGPP double bonds and preserving the allylic double bond (at position 2).  This reaction product is a reactive prenyl donor, which can be used as a substrate by archaeal prenyltransferases such as GGGP synthases.
What are the official names of this protein?
Digeranylgeranylglycerophospholipid reductase, DGGGPL reductase, 2,3-bis-O-geranylgeranylglyceryl phosphate reductase, Geranylgeranyl diphosphate reductase, GGPP reductase, Geranylgeranyl reductase, GGR.
What is the protein family that this protein belongs to?
Belongs to the geranylgeranyl reductase family.
Protein: Y4RE_SINFN
Sequence: MTAFARFLGEKVERYIDLRHSLGYAFSKQAGTLRAFVRYVERAQFDAPATRTMALDFVLSFGGAANSRATRHGVLRRFYEYLAVYDAQTEALKRRAFPRSRAIPPPRILSEAELASLIDACARISPGIPLRGLTMATLIGLLASSGLRSGEVVRLDRSDVDLTNGVLLVRKTKFRKDRLVPVHATTQTALCRYARERDAAFPSPKDQAFFLSSRGNRLSATGLQCGFAQVRKFAGLDDGKTLRPHDLRHRFAVTRMSLWHQQRANVQALLPVLATYLGHANYSDTAYYLTGSVDLLAMAAERAFLDGGAA
What are the official names of this protein?
Putative integrase/recombinase y4rE.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.