PharMolix/UniProtQA huggingface dataset:
Protein: ISPG_STRM5
Sequence: MHDAVTRPTPPSDATSWPRRQTHAVQIGGVTVGGGKPVVVQSMTNTDTSDVASSVKQVAELWRAGSEMVRLTVNTVEAAAAIPRIVDKLAMMGIDVPLIGDFHYNGHQLLTAEPACAEALAKYRINPGNVGFGKKKDLQFAQLIEFAIRYNKPVRIGANWGSLDQALAAKLMDENNHREQPWDAGRVLREALIRSALDSAEQAVEIGLPRDRIVLSAKVSGVQELIAVYRDLAQRSDFALHLGLTEAGIGSKGIVASSAALSVLLQEGIGDTIRISLTPEPGQSRTQEVIVAQELLQTTGQRAFTPLVTACPGCGRTTSEFFQELAKVVQSHVREKMPMWKIQHPGAENMTLAVMGCIVNGPGESRHANIGISLPGTGETPAAPVFVDGEKKVTLRGENIAQDFVALIDDYVERTYVRNAG
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: YOQZ_BACSU
Sequence: MLKFKNRIVEKRVKGAEKASFGGPVLLYRTLRKVTKLYKYITDKKSFPILVTSLFALFNPNSVLAADKYSNFEELKENESPLSYNILTTDVDRRVLILAPHGGGIEGGTSELARELSKSYSAYLFEGLRIPGASELHITSTNFDEPQALDLLSKHDLTISIHGYASSKKHTLVGGTDREKAAKITSLLTDAGFSAELLSEDSRLAGTNEQNIANKNSTGMSIQLEISTEQRREMFNTFTLAGRNGTQNQVFYDYIAVLTKFINENVYCMAGVAP
What are the official names of this protein?
SPbeta prophage-derived UPF0714 protein YoqZ.
What is the protein family that this protein belongs to?
Belongs to the UPF0714 family.
Protein: GCYH_DROME
Sequence: MACPFFRRADSLTRQPSVIAEPGGHWALEDEELSDDALTLTHLQMAIQLLTAPSNEDLNTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCANYDYLADIQELLLKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTGFVCAGEGELIFTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPNPGGTETCYFLESFRNPALDSELPLVEHINVSMKTISEGGDA
What is the function of this protein?
May have a role in phototransduction (PubMed:8095978).  Catalyzes the conversion of GTP to cGMP, a common second messenger that is utilized in a wide variety of cells and signal transduction pathways (PubMed:7797526).  A second subunit is required for enzyme activity (PubMed:7797526).
What are the official names of this protein?
Head-specific guanylate cyclase, Guanylyl cyclase alpha 1 subunit, Dgcalpha1, Gycalpha99B.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTH_ECO5E
Sequence: MTNYRVESSSGRAARKMRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLLLFVAAAYIVELIFSQPNLAQLGKGMVIPSLPTSEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGSRQQRYSATKWDVAIAMTIAGFVNLAMMATAAAAFHFSGHTGVADLDEAYLTLQPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFIRFHIPLWVRRTVTMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSDSKLMGDLVNSKRVKQTGWVIVVLVVALNIWLLVGTALGL
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPD_MICLC
Sequence: MTQTAAQQPSPRLVSGHGLATTAADGAVLDVWFPAPVAGPLSAADASLRDTLRALAADDADRGTTQAVVELEVDLDAAPASTADAWLRLHALSHRLARPNELNLDGVFGLLTNVVWTNHGPCAVADFELTRARLRARGAVQVYGVDKFPRMTDYVVPSGVRIGDADRVRLGAHLAEGTTVMHEGFVNFNAGTLGNSMVEGRISAGVVVGDGSDVGGGASIMGTLSGGGTQRIVVGEHVLLGANSGVGISVGDDCVVEAGLYVTAGTRVSVLQDGEAAHTVKAVDLSGVPNLLFRRNSTTGGVEALPRAGRTVELNAALHAN
What is the function of this protein?
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFQ_DELAS
Sequence: MSNKGQLLQDPFLNALRREHVPVSIYLVNGIKLQGQIESFDQYVVLLRNTVTQMVYKHAISTIVPGRAVNFSTAEAAGSDASA
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: SPTC1_HUMAN
Sequence: MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL
What is the function of this protein?
Serine palmitoyltransferase (SPT) (PubMed:19416851).  The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core (PubMed:19416851).  The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851).  The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851).  The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851).  Required for adipocyte cell viability and metabolic homeostasis (By similarity).
What are the official names of this protein?
Serine palmitoyltransferase 1, Long chain base biosynthesis protein 1, LCB 1, Serine-palmitoyl-CoA transferase 1, SPT 1, SPT1.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MGST2_BOVIN
Sequence: MAGNSILLAALSVLSACQQSYFAMQVGKARSKYKVTPPSVSGSPDFERIFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYSRHQYFWGYAEAAKKRVTGFRLSLGVLALLTVLGAVGILNSFLDEYLDIDIAKKLRHF
What is the function of this protein?
Catalyzes several different glutathione-dependent reactions.  Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE.  Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB).  Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4).  Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells.
What are the official names of this protein?
Microsomal glutathione S-transferase 2, Microsomal GST-2, Glutathione peroxidase MGST2, Leukotriene C4 synthase MGST2, Microsomal glutathione S-transferase II, Microsomal GST-II.
What is the protein family that this protein belongs to?
Belongs to the MAPEG family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Protein: RS4_SULDN
Sequence: MARYRGPVEKIERRFGVSLNLKGERRLAGKSALEKRPYAPGQHGQRRKKVSEYGLQLNEKQKAKFMYGVSEKQFRALFVEAKRREGNTGTNLVTLIEQRLDNVVYRMGFATTRRFARQLVTHGHLLVDGAKLDIPSYRVRPGQKIEIRESSKNNSQIVRALELTNQTGLAPWVDIDADKKFGIFTRLPEREEVVIPVEERLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PKG1_ADECT
Sequence: MEEKAGLGRLQNQQDEPAQDPHQRAGPRATFHSDRNHPNKEAEAMEGQNPACSRHASSHSIQPQASKPKKHRNYLDGAAVDDLKSLWDRLQTLQQSLTNMPYAEGLKPLKNFASFEELLSMGGDSLLNDLLDIQDSITQCCMKVSKYLNKDGSCASLNYYKQPFIAAVYGPTGCGKSQLLRNLMSAQLIVPAPETVFFITPQVDMIPPQEIAAWETQICEGNFLAGPENTVVPQSGSIMPKFVQMSYAELTNEANYDVTNPTNVFARAASKGPLAIVMDECMEDLGGNRGIAKFFHAFPSKLLDRFPKCTGYSVIVVLHNMNPRRDQGGNIANLKIQAKMHIISPKVHPSQLNRFINIYTKGQPTAISLLLKDIFNYHRLNTNFDWIVYNTEPIDNCMHWLYLSPDEGLIPMYLNIQAKVYQAMERIHRTITDRQRWTRYYHSKKK
What is the function of this protein?
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP).  Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery.  The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase.  May be the protein that pumps DNA into the capsid powered by ATP hydrolysis.  Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence.  Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication.  DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
What are the official names of this protein?
Packaging protein 1, Packaging protein IVa2.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae packaging protein 1 family.
What are the subcellular locations of this protein?
Virion. Host nucleus, host nucleoplasm. Host nucleus, host nucleolus. Note=Located at a unique vertex of the capsid. Present in about 6-8 copies per virion.
Protein: TM231_XENTR
Sequence: MALYEVYSHPALLRYRSSICSKATLFILIVLLLTYIPPLLVAFRSYGFWLKTSTYEEQPNVRFQYDVLLIALSSTTGNYLAWSTYPGFNNLVGDKLRLPHISAREEDRNQDGKMDLLNFQLELPLQPTDNIYGVQLILTFSYQLSKMSTFIMQSMALIQYSSPIPGSQLYMNGDLKLQQRQPLNHRGLDTTYNVSVINRSSPFASTYALTNIISSYQERNVTTVLNAPNPLWIVGRAASDPFVIKAVIRYPVESISYVPGFWEMLKYAWIQYVSILLIFLWVFERIKIFVFQNQVLTTVSGPIPSLYKSHQS
What is the function of this protein?
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.  Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
What are the official names of this protein?
Transmembrane protein 231.
What is the protein family that this protein belongs to?
Belongs to the TMEM231 family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Multi-pass membrane protein. Note=Localizes to the transition zone of primary cilia; SEPT2 is required for localization to the transition zone.
Protein: RSXA_ECO8A
Sequence: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLNLIYLRTLAFILVIAVVVQFTEMVVRKTSPVLYRLLGIFLPLITTNCAVLGVALLNINLGHNFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rsx electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COX2_MYCPA
Sequence: MTPREQDRSQPLSQGRFPGRVGRRVLRPLALAVTLGVLAIVLSGCSSWADALALGWPKGITPQAHLNRELWIGAVIASLVVGAIVYGLIFWASAFHRKKATDTELPRQFGYNMPLELVLTVTPFLIISVLFYFTVVVQEKMLHIAKDPEVVVDVTAFQWNWKFGYQKVNFKDGTLTYDGADPERKKAMVSKPEGKDAHGEERVGAVRGLNTSDRTYLNFDKVETLGSSDEIPVLVLPTGKRIEFDLASADVVHTFWVPEFLFKRDVIPNAEANNSIHVFQVEEINSPGAFVGHCAEFCGTYHSMMNFEVRVVSPNDFKAYLQQRMDGKSNAEALQAIGQSPVAVTTHPFDSKRGQLAGSQ
What is the function of this protein?
Subunits I and II form the functional core of the enzyme complex.  Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).
What are the official names of this protein?
Probable cytochrome c oxidase subunit 2, Cytochrome aa3 subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DUT_SHESW
Sequence: MKTPIELKILDSRIGSEFPLPAYATLGSAGMDLRAMIDTTMTIAPGETQLIPTGIAIHVADPGLAAVILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRSNSPFTLDIGDRLAQLVFVPVVQAQFKLVDEFDSSDRGEGGFGHSGTK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: SH2B2_MOUSE
Sequence: MNGATPSSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGSAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHAATKARVRKGFSLRNMSLCVVDGVRDLWHRRSSPEPDGGATPKAAEPASEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVASCSCELLTDADMPRPPETTTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSENNNPGDEGAELDTDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPASPSNGAGASSSSGSSSSATSLPPRPAEGPLSAHSRSNSTEHLLDAASGATEEPTEATLGRARAVENQYSFY
What is the function of this protein?
Adapter protein for several members of the tyrosine kinase receptor family.  Involved in multiple signaling pathways.  May be involved in coupling from immunoreceptor to Ras signaling.  Acts as a negative regulator of cytokine signaling in collaboration with CBL.  Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR.  Suppresses PDGF-induced mitogenesis.  May induce cytoskeletal reorganization via interaction with VAV3 (By similarity).
What are the official names of this protein?
SH2B adapter protein 2, Adapter protein with pleckstrin homology and Src homology 2 domains, SH2 and PH domain-containing adapter protein APS.
What is the protein family that this protein belongs to?
Belongs to the SH2B adapter family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region (By similarity).
Protein: G6PI2_CHRSD
Sequence: MSQSTMIHHSEAWQALTQHADGMRNVHLKSLFAEAPGHHARFTRRGAGLTLDLSKHRWRDETLTKLLALAREANLERAIERLQNGERVNLSEDRPALHTALRLPPEASLVVEGEDVVPDVHETLARMQAMVEKCHAGQWRGATGKAITDVVNLGVGGSDLGPLMVTHALADYRPRDVHQVDIHFASTMDGSQLADYLTRFNPATTLFVLSSKSFTTIDTLSNASTARDWLMTRLADGGRDAGMREVVMRQHFIGVSAKPERMSEWGIDPRHQLRFWEWVGGRYSLWGAIGLPIALAVGMENFRELLAGAHEMDRHFRDTPLEDNLPVLLALAGIWNVNFLDVRAHSILPYDGRLEYFASYLEQLEMESNGKSVTNDGEITPYSTCPVLWGQLGPNAQHAFYQLLHQGTQAVECDFIAPVRRYDRVEDPATRAHLKAQHRLTLANCIAQSRVLMLGDEALPSDAPRPSHKRYRGNQPSTTLLLDRLTPRTLGALIALYEHKVFVQATIWDINPFDQWGVELGKQIASETEQILASRRGAETLDDSSRGLLDVVWQAQDAT
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase 2, GPI 2, Phosphoglucose isomerase 2, PGI 2, Phosphohexose isomerase 2, PHI 2.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3P_METMA
Sequence: MVKAKIAVNGYGTIGKRVADAVQAQDDMEIIGVSKTKPNYEAAVAHQKGYDLFAPASNSGAFEKAGIPLAGTIEEMVEKADLVVDCTPGGIGEANKPMYEKAGVKAIWQGGEDHELAGFSFNAASNYEGALGRDLVRVVSCNTTGLCRVIYPIDRELGVKKVRVTLARRATDPNDIKKGPINAIVPDPIKLPSHHGPDIKSVLPHINITTAALKIPTTLMHLHTVNMEVNTDCTAEDINRIFSSQSRIRFMSQGINSTAEIIELARDMGRPRNDMWENCIWPESITVHEREFYFFQAIHQESIVVPETVDAIRAMMELESDGAKSIQKTNKAIGL
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_VARPS
Sequence: MKASRFFVSTLKEAPADAEVASHRLMMRAGMIKKLGTGIYTYMPMGLRVIRKVEAIVREEMNRAGAVELTMPVVQPAEFWQETGRFDKMGPELLRIKDRHDRDFVVQPTSEEVVTDIARQEIRSYKQLPKNFYQIQTKFRDERRPRFGLMRGREFIMKDAYSFDRDLDAAKASYQAMADAYRRIFDRFGLRYRAVAADSGAIGGDLSEEFQVIAATGEDAIVYCPGSDYAANMEKAEALAPAGPRPAAAKALEKTPTPGKSTCADVAELLGVPLSTTVKSLVLATDILDEAGNPKGSQVWLLLLRGDHDMNEIKVGKVPGLDKGFRFATLAEIDDHFGCKPGYLGPLNLKKPVRLVADREVMVMADWITGANEVDFHMTGVNWGRDLPEPELVADLRNVVAGDASPDGKGVLAIERGIEVGHVFVLGTKYSKDMNATYLDEAGKPQFLEMGCYGIGITRLPAAAIEQNHDERGIIWPDALAPFTVVVCPIGMDRSPEVKVAAEALYEQLLAAGVDVLLDDRGERPGAMFADWELIGVPHRVVISDRGLKEGQLEYQHRRDTAATKVPAAGIAEFIAGKFAQ
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSCL_STAA1
Sequence: MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWGIKYGLFIQSVIDFIIIAFALFIFVKIANTLMKKEEAEEEAVVEENVVLLTEIRDLLREKK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TGT_STAA3
Sequence: MPAVTYEHIKTCKQSGARLGIVHTPHGSFETPMFMPVGTKATVKTMSPEELRQIEAKIILGNTYHLWLQPGNDIIKHAGGLHKFMNWDGPILTDSGGFQVFSLSNLRKITEEGVEFRHHTNGSKLFLSPEKSMQIQNDLGSDIMMAFDECPPMPAEYDYVKKSIERTTRWAKRCLDAHQRPEDQALFGIIQGGEYEDLREQSAKDLVELDFPGYAIGGLSVGEPKPVMYKMVEHTEQFMPKDKPRYLMGVGSPDALIECSIRGMDMFDCVLPTRIARNGTCMTSQGRLVIKNAKFADDLRPLDENCDCYTCQNYSRAYIRHLIKAEETFGIRLTTIHNLHFLLKLMEDIRQAIREDRLLDFKEEFFEQYGLNVENPKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: SUI1_METTP
Sequence: MSSEMCTVCGLPKELCICEEVAKEQQRIVVKIHKRRYGKEVTVIQGIDPHEIDLQDLCTYLKSKLACGGTVKDGVIELQGNHIGRIKDLLSKKGFSASQISL
What are the official names of this protein?
Protein translation factor SUI1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: MNMG_SHESH
Sequence: MHFHERFDVIVIGGGHAGTEAALAAARMGSKTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEIDALGGAMAIATDYAGIQFRTLNSSKGPAVRATRAQADRALYRAKIQEILQNQPNLRLFQQAVDDLIVENGKVTGVVTQMGLAFEAPAVVLTAGTFLSGKIHIGMQNYSGGRAGDPPSIALADRLRELPIRIGRLKTGTPPRIDANTINFDLMTEQKGDTPLPVMSFIGDVSHHPRQVSCFVTHTNERTHDIIRGGLDRSPMYSGIIEGVGPRYCPSIEDKINRFADKSSHQIFIEPEGLNTNEIYPNGISTSLPFDVQLNLVRSIKGMENAEIIRPGYAIEYDYFDPRDLKNSLETKSIQGLFFAGQINGTTGYEEAGAQGLLAGMNASLQVQGKESWCPRRDEAYLGVLVDDLSTLGTKEPYRMFTSRAEYRLLLREDNADLRLTEKGHQIGLVDEDRWAKFNKKRESIELELQRLRSQWVHPNSPLLEVLNPELNTPISREASFEDLLRRPEMDYPKLMSLEGFGPALEDQRAAEQVQIQVKYSGYIQRQQDEIDKAIKHETTGLPLELDYQEVPGLSNEVIAKLNDHKPETIGQASRISGMTPAAISILLVHLKRRGLLRKNPSKS
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_PSEPG
Sequence: MDIKSALARIVGHLDLSTEEMRDVMRQIMTGQCSEAQIGAFLMGMRMKSESIDEIVGAVSVMRELADKVELKSLDGVVDIVGTGGDGANIFNVSTASAFVLAAAGCTVAKHGNRAVSGKSGSADLLEAAGIYLNLTPTQVARCIDSLGIGFMFAQSHHSAMKHAAGPRRELGLRTLFNMLGPLTNPAGVKHQVVGVFAQALCRPLAEVLQRLGSKHVLVVHSKDGLDEFSLAAPTFVAELKNDEITEYWVEPEDLGMKSQSLHGLAVDNPQASLELIRDALGRRKTENGQKAAEMIVLNAGAALYAADHAMTLAQGVELAHDVLHTGLAWEKLQELGAFTAVFKVENEA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RGMG1_BURO1
Sequence: MFTARIARSMASESAPAASSVAPGSSGAPMADCVLEVRGVGKSFPGVVALDGVQFRVRRGTVHALMGENGAGKSTLMKIIAGVYTPDQGEILINGEPVVLNGPLDALDRGIAMIHQELNLMPYMTVAENIWIRREPKNRFGLIDHAELRRRTAALFERLSIDIDPETDVRTLTVASRQMVEIAKAVSFDSDVLIMDEPTSALTDKEVTHLFRIIRQLREQGKGIVYITHKMNELFEIADEFSVFRDGKYIGTHASSDVTRDDIIRMMVGREITQMFPKEEVPIGDVVLSVKDLCVDGVFRDVSFELRAGEILGVAGLVGSGRSNVAEALFGVVPATSGEIRIDGKPVRISTPAQAMKHGMAFLTEDRKDSGCFLNLDLLANMEAAVLSRRYVKFNFVQQAQLKRDCEEMSRMLRVKSPGLHEEIQNLSGGNQQKVLIGRWLLTQPRILILDEPTRGIDVGAKAEIHRLVSALAGKGVAVLMISSEMPEVLGMSDRVMVMHEGRMTGIVDRKDADQVRIMDLASR
What is the function of this protein?
Part of an ABC transporter complex involved in carbohydrate import.  Could be involved in ribose, galactose and/or methyl galactoside import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Putative ribose/galactose/methyl galactoside import ATP-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Carbohydrate importer 2 (CUT2) (TC 3.A.1.2) family.