PharMolix/UniProtQA huggingface dataset:
Protein: RL13_BUCBP
Sequence: MYIKSFSAKSNDFKKMWYCIDATGKILGRLATNIASRLRGKHKVEYTPHVDIGDYLIVINAKNIKVTGKKCTDKFYYHHTGYVGGLKKIAFKDMLHRYPERIIEIAVRGMLPKGPLGRSMFKKLKVYANDNHNHSAQNPKILNI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: Y705_STAA9
Sequence: MTHIIIDGDACPVVDSIIDLTTETGIFVTIIRSFSHFSNQLYPPHVSTLYVDDGPDAVDYKIVQLSTKDDIVVTQDYGLASLLVDKVLIVMHHNGKIYNSKNIQQLLDKRYINAQIRKQGGRHKGPPPFTKQDQKVFEQSLLKVIHRIKELD
What are the official names of this protein?
UPF0178 protein SaurJH9_0705.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: FYV4_YARLI
Sequence: MLRVVAKAQYPAAVRCFSTSHAAFAKVSFESSEDFLKKIGRDTVKLAEKFETWDELKNSTSSDLKEKGIEARDRRYIMTQLYRYKNGEKIREIPRGKKTWGGERKRNLVQALFKAGQN
What is the function of this protein?
Involved in telomere length regulation.
What are the official names of this protein?
Protein FYV4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RT31_RAT
Sequence: MLHRIPAFIRPRPFSGLPLSCGNREVSVAASVLPAAGSGAVRTENTIQRHFCTSRSICSKKDDQSVPANETSQKAAESQGEGKETLKKNLLDVIKDMKVQLNTANVKTTKPRGRQPPAHLETAVGRLQKALGEPPRKRNEFLSPELVAAASAVADSLPFDKQTTKSELLKQLQQHEEESRAQTDRQKRRVSFTQIISNMKIAKSPSMRVSSRPQHQIQFDEEVDSSLSQEKPADFRRRKCLFKGKRLSIFDVKAFDDEAPEPEAAPSLWEIEFAKQLATVSEQPFGNGFEEMIQWTKEGKLWEFPVNNEAGLDDDGSEFHEHIFLEKHLEDFPKQGPIRLFMELVTCGLSKNPYLSVRQKVEHIEWFRNYFNEKRDILKENNIHLTS
What are the official names of this protein?
28S ribosomal protein S31, mitochondrial, MRP-S31, S31mt.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS31 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MSCL_LISMO
Sequence: MKKMLVEFRDFALKGNVLDLAVAVVIGAAFGKIVSSLVDNIIMPLVGVLLGGLDFTDLSFKVGKSVIQYGAFIQSIVDFIIIAFAIFIFVKVLTSFIKKKEQTVEETPVPPTEEYLKEIRDLLKEQQK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLMF_KLEP7
Sequence: MKAQKPGLHPRNRHHQRYDLPALCQAHPDLQGYITLNPLGEQTIDFANPQAVKALNKALLAHFYAVKHWDIPDGFLCPPVPGRADYIHHLADLLAGDSGEVPKDATILDIGTGANLIYPLIGAHEYGWRFTGSEINPQAFASAQAIINGNPGLTRQIRLRRQKESQAIFHGVIHKNETYDATLCNPPFHDSAESARAGGERKRRNLGLGAESGLNFGGQQQELWCEGGEVAFISQMIRESQAFARQVKWFTSLVSRGDNLPPLYRLLTEVGAVKVVKKEMAQGQKQSRFIAWSFMDDAKRRRPF
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEFCG_CRAGI
Sequence: MKVFVLLTLAVLLMVSADMAFAGFGCPGNQLKCNNHCKSISCRAGYCDAATLWLRCTCTDCNGKK
What is the function of this protein?
Antibacterial peptide mostly active against Gram-positive bacteria (M. lysodeikticus, S. aureus, and the marine bacteria, B. stationis, and M. maritypicum) (PubMed:16246846).  It acts by selectively inhibiting peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20605792).  It does not disrupt cell membranes (PubMed:20605792).  Is noticeably more potent than Cg-Defh1 (PubMed:20605792).  It shows no or limited activities against Gram-negative bacteria and filamentous fungi (PubMed:16246846).
What are the official names of this protein?
Defensin Cg-Defm, Cg-Def, Mantle defensin.
What is the protein family that this protein belongs to?
Belongs to the invertebrate defensin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: PIG20_CLAP2
Sequence: MVAPHESQRVADSCSHLVGREIGCSRDLAGCRRCTSEGRACSYSRSGVIHRTRRRNRANQDVTRSALYSSNTTPQTISDQATGRPCEGADNTETAYDRLQQIIPSRSHQSVRVIAELLEEYTEAWQGSEAFEKLSKAPIAEFFVFSEPQTRCWLDNLNLILEKEELLIFTIPPEVYAQLASSRPQEVQDRSWLVMFYSVAIYVEHSKAQNTHRVATLSKLRRNLWLAFNDVRLLIEPSPARIQALIILATYVEEFMTPCVCWSLITKACTMLQALGIVHWRLDTATSDVRAMLFWRLNMLDKALALILCRAPAFHREMSSQIAMPTLNRLMQCRPKRTKDYPPALFEAHYLHQMHLVSCIMADVWHALYGQDTEKVQEVKERLEAWYRQAKEVIEAAALVERPLLTAKGAAAVDLGRQTLRFQYLSLVVLLTVSSRQLRSQSIGPSQEMLNLLSALGDAIPDHKGPYACLLWQYLHCPLAAFGALWGELVMKTTANPEQSLKSMEAIAHLPLYLGKLGSRHALAARLQSITARIVEQARMIVNSQEAPEALPVQDEPTNPGLPAPAAEILPIVAPNESLDPTQMQPVDDFLDDRFIMQSDPFFGTTFDWFAWGGNLEV
What is the function of this protein?
Transcriptional regulator; part of the ergochrome gene cluster responsible for the typical purple-black color of the ergot sclerotia (Probable).  The ergochrome gene cluster produces several ergot pigments including the yellow ergochrome secalonic acid and its derivatives, as well as the red anthraquinones endocrocin and clavorubin (PubMed:28955461).
What are the official names of this protein?
Transcriptional regulator CPUR_05421, Ergochrome biosynthesis cluster protein CPUR_05421.
What are the subcellular locations of this protein?
Nucleus.
Protein: HPRK_ACIAC
Sequence: MKPNVVSADVLFEAFRSPLKWEWVAGLGASERRFDEVAVRSARSGADLVGYLNYIHPYRVQILGEREIAYLVNATPEDCKRRIARIVTLEPPVLVLADSQMAPDALLSMCERAQIPMFATHESSAFVIDVLRAYLSKHFADRITMHGVFMDILGLGVLITGESGLGKSELGLELISRGNGLVADDAVDFFRINQTTIEGKCPDLLQNLLEVRGIGLLDIRAIFGETAVRRKMRLRLIVHLVRKETLEREYERLPYEPLTQDVLGVPVLKVVIQVVAGRNIAVLVEAAVRNTILNLRGIDTYQEFVERHRRAMEQRDGS
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: SYE_BURP1
Sequence: MTRPVRTRFAPSPTGFIHLGNIRSALYPWAFARKMKGTFVLRIEDTDLERSTEASVDAILEGMAWLGLDYDEGPYYQMQRMDRYREVLAQMLEKDLVYPCYMSTEELDALRERQRAAGEKPRYDGTWRPEPGKVLPEPPAGVTPVLRFRNPLTGSVVWDDAVKGRVEISNEELDDLVIARPDGTPTYNFCVVVDDLDMGITHVIRGDDHVNNTPRQINILRALGGEVPVYAHLPTVLNEQGEKMSKRHGAMSVMGYRDAGYLPEAVLNYLARLGWSHGDAEIFSREQFVEWFDLEHLGKSPAQYDHNKLNWLNNHYIKEADDARLAELAKPFFAALGIDADTIARGPDLVGVMGLMKDRASTVKEIAENSTMFYRAPAPDAQALAQHVTDAVRPALAEFAAALKTAEWTKEAIAAALKAVLGAHKLKMPQLAMPVRLLVAGTTHTPSIDAVLLLFGRDVVVSRLAAALA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRR27_ARATH
Sequence: MISKFGSVHILAVVAIQLLIIPSVSSLNLTNAYLHHKCNNTEGKYSHGSAFEKYINLALRAIDSDNYLNGFAYIERGEDPNKVFVMYQCRGDSYGSKCKSCISAAISGLRRRCPKSKGAVIWYDQCLFEISTINSFNKIDYENDFYLSNPNDVNDKELFNKETSALLEELTNKATDKNNMIGNKFVLYAAGDKRIGTKNVYAMVQCTKDLVTTTSAACFEWIFKMFSKCCEGKQGGRVLGTSCNFRYELYPFLRN
What are the official names of this protein?
Putative cysteine-rich repeat secretory protein 27.
What is the protein family that this protein belongs to?
Belongs to the cysteine-rich repeat secretory protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: FLIT_BACLD
Sequence: MEKIELLYSETKHMLAQIKGAPESDELVQAIEDFLKKRDGLIREIKPPLSETEKRQLQQVTDMEPLIMAELKRLQQAVKQELLQAKQKRAMHHSYINPYANMTIDGTYYDKRK
What is the function of this protein?
May act as an export chaperone for the filament capping protein FliD.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the bacillales FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: CELB_EMENI
Sequence: MALLLSLSLLATTISAQQIGTPEIRPRLTTYHCTSANGCTEQNTSVVLDAATHPIHDASNPSVSCTTSNGLNPALCPDKQTCADNCVIDGITDYAAHGVETHGSRLTLTQYRNVNGALSSVSPRVYLVDESDPDEQEYRALSLLAQEFTFTVNVSALPCGMNGALYLSEMSPSGGRSALNPAGASYGTGYCDAQCYVNPWINGEGNINGYGACCNEMDIWEANSRSTGFTPHACLYEPEETEGRGVYECASEDECDSAGENDGICDKWGCGFNPYALGNTEYYGRGQGFEVDTKEPFTVVTQFLTDDGTSTGALTEIRRLYIQNGQVIENAVVSSGADSLTDSLCASTASWFDSYGGMEGMGRALGRGMVLAMSIWNDAGGYMQWLDGGDAGPCNATEGAPEFIEEHTPWTRVVFEDLKWGDIGSTFQAS
What is the function of this protein?
Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan.  Involved in the degradation of complex natural cellulosic substrates.
What are the official names of this protein?
Endo-beta-1,4-glucanase celB, Endoglucanase celB, Carboxymethylcellulase celB, Cellulase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPRT_RAT
Sequence: MVDLWPVSTRPRVLFRAAPSLLNSASAASMLWAELIAMAPSIPSALPPFS
What is the function of this protein?
Neurite outgrowth factor.
What are the official names of this protein?
Sproutin, TA20.
Protein: PARG_RAT
Sequence: MSAGPGCEPCTKRPRWGAAGTSAPTASDSRSFPGRQKRVLDPKDAPVQFRVPPSSSACVSGRAGPHRGSVTSFVFKQKPITTWMDTKGPKTAESESKENNNTRTDPMMSSVQKDNFYPHKVEKLGNVPQLNLDKSPTEKSTPYLNQQQTAGVCKWHSAGERAEQLSASEPSAVTQAPKQLSNANIDQSPPTDGHSDTDHEEDRDNQQFLTPVKLANAKQTVGDGQARSNCKCSASCQCGQDCAGCQREEADVIPESPLSDVGAEDIGTGSKNDNKLTGQESGLGDSPPFEKESEPESPMDVDNSKTSCQDSEADEEASPVFDEQDDQDDRSSQTANKLSSRQAREVDGDLRKRYLTKGSEIRLHFQFEGGSNAGTSDLNAKPSGNSSSLNVDGRSSKQHGKRDSKITDHFVRIPKSEDKRKEQCEVRHQRAERKIPKYVPPNLPPDKKWLGTPIEEMRKMPRCGVRLPLLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCDKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRCCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPPENLSAVATGNWGCGAFGGDARLKALIQLLAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLNVGKVYRLLLRYYREECRDCSSPGPDTKLYPFIYHAAESSAETSDQPGQRTGT
What is the function of this protein?
Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose).  PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers.  It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated.  Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG.  Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress.  Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond.  Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters.  Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5.  Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.
What are the official names of this protein?
Poly(ADP-ribose) glycohydrolase.
What is the protein family that this protein belongs to?
Belongs to the poly(ADP-ribose) glycohydrolase family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with PCNA at replication foci. Relocalizes to the cytoplasm in response to DNA damage (By similarity).
Protein: Y4704_VIBA3
Sequence: MGRSFEVRKASMAKTAGAKIKVYSKYGKEIYVLAKNGSSDPDMNLPLKHLIAKAKKDQVPAHVIDKAIDKANGGGGEDFQPARYEGFGPGGTSVIVDCLTDNGNRTFQDVRQCFVKTGAKIGVEGTVSHMFAHQAVFQFAGEDDEIILETLMMEDVDVTDVELEDGVITVFAPTTEFFKTKTALNAAFPDLTLDVEEITFVPQTTTPIAEEDSEKFQKFLDMLDDCDDVQQVYHNAEL
What are the official names of this protein?
Probable transcriptional regulatory protein VS_II1504.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YD2M_HERAU
Sequence: MIATGAYLWTLREAIGLCRNDVAHEAGTNNVQIMRIEKGEIDTRGSLLLSVVRAVNFNAEHIAQLFLMLVATEEDGRNLAISWINRETTSAIDEFIADVKKDNKVSEALKLIQQLEALDPSSLDRLLGYGQSLLDRNR
What are the official names of this protein?
Uncharacterized 15.4 kDa protein in HgiDIIM 5'region, ORF15.
Protein: NR1H2_MOUSE
Sequence: MSSPTSSLDTPVPGNGSPQPSTSATSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKRIQKQQQQQPPPPSEPAASSSGRPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
What is the function of this protein?
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281).  Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) (PubMed:18055760, PubMed:19520913, PubMed:20427281).  Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8 (PubMed:18055760, PubMed:19520913, PubMed:20427281).  Interplays functionally with RORA for the regulation of genes involved in liver metabolism (PubMed:18055760, PubMed:19520913, PubMed:20427281, PubMed:24206663, PubMed:28846071).  Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (PubMed:28846071, PubMed:25806685).  Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685).  Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (PubMed:24206663).  Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity).
What are the official names of this protein?
Oxysterols receptor LXR-beta, Liver X receptor beta, Nuclear receptor subfamily 1 group H member 2, Retinoid X receptor-interacting protein No.15, Ubiquitously-expressed nuclear receptor.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PUR5_CLOB1
Sequence: MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDGVGTKLDIAFRMKKYNTVGIDCVAMCINDILCHGAKPLFFLDYIACGKLEAEVAAQLVEGVSNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEKDEIIDGSKIEDGDILIGIASSGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGGGFYENIPRMFKEDFTAVINKKSYPLPNIFSHLISLGIEEDHMYNTFNMGIGFVLCVNEKDGENIIKDLIEMGEKGYKIGYVKKGDKSVELI
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O269_CONIM
Sequence: MEKLTILLLVTAVLMSTQALMQSGIEKRQRAKIKFFSKRKTTAERWWEGECYDWLRQCSSPAQCCSGNCGAHCKAW
What is the function of this protein?
Probable neurotoxin.
What are the official names of this protein?
Conotoxin Im6.9, Conopeptide im019.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RUVC_SHEB9
Sequence: MAIILGVDPGSRITGYGVIQCQGRHQIYLGSGCIRTSSEELPGRLKQIFDGITEIIRQYQPDEFAIERVFMAKNADSALKLGQARGAAIVAATVANLPVAEYSATQIKSAVVGTGRAQKAQVQHMIQQLLKLPAAPQADAADALGVAVCHYHTSQSLIALSGRATARTYGRYR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: POPB_AMABI
Sequence: MPPTPWAPHSYPPTRRSDHVDVYQSASRGEVPVPDPYQWLEENSNEVDEWTTAQTAFTQGYLDKNADRQKLEEKFRASKDYVKFSAPTLLDSGHWYWFYNSGVQSQAVLYRSKKPVLPDFQRGTRKVGEVYFDPNVLSADGTAIMGTCRFSPSGEYFAYAVSHLGVDYFTIYVRPTSSSLSQAPEAEGGDGRLSDGVKWCKFTTITWTKDSKGFLYQRYPARESLVAKDRDKDAMVCYHRVGTTQLEDIIVQQDKENPDWTYGTDASEDGKYIYLVVYKDASKQNLLWVAEFDKDGVKPEIPWRKVINEFGADYHVITNHGSLIYVKTNVNAPQYKVVTIDLSTGEPEIRDFIPEQKDAKLTQVKCVNKGYFVAIYKRNVKDEIYLYSKAGDQLSRLASDFIGVASITNREKQPHSFLTFSGFNTPGTISRYDFTAPDTQRLSILRTTKLNGLNADDFESTQVWYKSKDGTKVPMFIVRHKSTKFDGTAPAIQNGYGGFAITADPFFSPIMLTFMQTYGAILAVPNIRGGGEFGGEWHKAGRRETKGNTFDDFIAAAQFLVKNKYAAPGKVAITGASNGGFLVCGSVVRAPEGTFGAAVSEGGVADLLKFNKFTGGMAWTSEYGNPFIKEDFDFVQALSPVHNVPKDRVLPATLLMTNAGDDRVVPMHSLKFVANLQYNVPQNPHPLLIRVDKSWLGHGFGKTTDKHTKDAADKWSFVAQSLGLEWKTVD
What is the function of this protein?
Dual function macrocyclase-peptidase involved in the biosynthesis of the highly toxic amanitin toxin family of macrocycles (PubMed:20889720).  Cleaves peptide bonds on the C-terminal side of prolyl residues (By similarity).  The enzyme first removes 10 residues from the N-terminus of a 35-residue substrate (By similarity).  Conformational trapping of the 25 amino-acid peptide forces the enzyme to release this intermediate rather than proceed to macrocyclization (By similarity).  The enzyme rebinds the 25 amino-acid peptide in a different conformation and catalyzes macrocyclization of the N-terminal eight residues (By similarity).
What are the official names of this protein?
Dual function macrocyclase-peptidase POPB, Prolyl oligopeptidase B, POP B, Toxin-processing prolyl oligopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9A family.
Protein: KEFF_CITK8
Sequence: MILIIYAHPYPQHSHANKRMLEQARTLDGVEIRSLYQLYPDFNIDVAAEQQALARARLIIWQHPMQWYSVPPLLKLWMDKVLAHGWAYGHGGTALRDKDLMWAVTTGGGESHFAIGAYPGFDVLSQPLQATALYCGLNWLPPFAMHCTFVCDDETLQAQARHYKQRLLAWQEANHG
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefC.  Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefF, Quinone oxidoreductase KefF.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VL1_HPV17
Sequence: MTLWLPTTGKVYLPPTPPVARVQSTDEYVERTNIFYHAMSDRLLTVGHPFYDVRSTDGLRIEVPKVSGNQYRAFRVTLPDPNKFALADMSVYNPEKERLVWACAGLEIGRGQPLGVGTTGHPLFNKLRDTENNSSYQGGSTDDRQNTSFDPKQVQMFVVGCVPCIGEHWDRAPVCENEQNNQTGLCPPLELKNTVIEDGDMVDIGFGNINNKVLSFNKSDVSLDIVNETCKYPDFLSMANDVYGDACFFFARREQCYARHYFVRGGNVGDAVPDGSVNQDHKFYLPAQTGQQQRTLGNSTYFPTVSGSLVTSDAQLFNRPFWLRRAQGHNNGILWGNQIFVTVADNTRNTNFSISVSTEAGAVTEYNSQNIREYLRHVEEYQLSFILQLCKIPLKAEVLTQINAMNSGILEDWQLGFVPTPDNPVHDIYRYINSKATKCPDAVVEKEKEDPFAKYTFWNVNLTEKLSLDLDQYPLGRKFIFQSGLQARPRTIRTSVKVPKGIKRKRS
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: YORJ_TTV1K
Sequence: MDMHMLRLLDLQCILHHRLQERMRATSVKLRQYPQILQQHRCGLHPRSLL
What are the official names of this protein?
Uncharacterized 6.1 kDa protein.
Protein: RUTD_ECO44
Sequence: MKLSLSPPPYADAPVVVLISGLGGSGSYWLPQLAVLEQEYQVICYDQRGTGNNPDTLEEDYSIAQMAAELHQALVAAGIERYAVVGHALGALVGMQLALDYPASLTVLVSVNGWLRINAHTRRCFQVREQLLHSGGAQAWVEAQPLFLYPADWMAARAPRLEAEDALALAHFQGKNNLLRRLNALKRADFSRHTDRIRCPVQIICASDDLLVPSACSSELHAALPDSQKMVMRYGGHACNVTDPETFNALLLNGLASLLHHREAACKELL
What is the function of this protein?
Involved in pyrimidine catabolism.  May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously.
What are the official names of this protein?
Putative carbamate hydrolase RutD, Aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Hydrolase RutD family.
Protein: ATPA_NATTJ
Sequence: MSIRPDEISTVLKDKIANYESQVDVYEVGTVLYIGDGIARVHGLENVMANELVEFPGEIYGMALNLEEDNVGCVLLGEYSHIKEGDQVKRTGRIIEVPVGDDLVGRVVNPVGEPRDGKGPIEATDFRPVETRAPGVIDRKPVEEPLQTGLKAIDSMIPIGRGQRELIIGDRGTGKSAIGIDTILNQKDSDVYCIYVAIGQKKSTVAQVVDVLERHGAMDYTTVVAATADEPAPLLYLAPYAGCSMGEKFMHEGKHVLVVYDDLSKHAASYRELSLLLRRPPGREAYPGDIFYLHSRLLERAAKLNDENGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLISDLFHAGQRPAVDVGISVSRVGGSAQLKGMKQVSGTLRLDLAQYRELEAFAQFGTDLDKSTQQKLARGKRTFEILKQDQYQPMPVADQIVIIFCATHGLLDDLEVEQIKEFEKFLLSYVKDNEPGIYQQVETGEKISDELEDQLKEVINKAKEQFKEEKELTG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.