PharMolix/UniProtQA huggingface dataset:
Protein: EMTA_SHIF8
Sequence: MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSDRKKAISKINDLDADEFLDHVARNHPAPQAPRYIYKLEQALDAM
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.  Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.
What are the official names of this protein?
Endo-type membrane-bound lytic murein transglycosylase A, Peptidoglycan lytic endotransglycosylase.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: LPXB_CHLFF
Sequence: MLPLHLVHVLYPIGLIANLFFGSAFTIQWFLSERRKKACVPKSFWILSSIGAVMMIAHGFIQSQFPIALLHGANLVIYFRNLNVSSSHSLSLRATLFILVVTLLLTTLPFVLGSYYYPNMQWMASPNIFHLPLPPPNIYWHIAGCIGLFTFSSRFFIQWCHLEINNRSTLPALFWLVSFIGGFLAFLYFIRTGDPVNIISYGCGLLPSLANLLIIYKKSRLPEFHNHSYFLSAGEPSGDILGSDLLHNIKTCDPTIRCFGVGGPLMRKEGFEPLIHMEEFQVSGFLEVFFSIFGLFKKYRRLYKAILQENPETVFCIDFPDFHFFLIKKLRKCGYKGKIIHYVCPSIWAWRPKRKKILEKYLDTLLLILPFEKDLFINSPLKTIYLGHPLVKTISNFQYCSSWKQQLSISDQPIVALFPGSRPGDIFRNLQVQIRAFLASSLAQSHQILVSSCNPKYDKNILDVLEKEGCRGKIISSTFRYQLMRDCDCALAKCGTIVLEAALNQTPTIVTCLLGPIDTFLAKYIFKILMPAYSLPNIITGSIIFPEFIGGKHDFNPEEVAAAIDILAKPKSKEKQKLACQQLLDTLMTNVVTPEECLRIICSQNSHLHLEKGILKNLHPRDSSV
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the LpxB family.
Protein: 1433_CHLRE
Sequence: MAVDREECVYMAKLAEQAERYDEMVEEMKKVAKLVHDQELSVEERNLLSVAYKNVIGARRASWRIISSIEQKEEAKGNEEHVQRIRKYRTVVEEELSKICASILQLLDDHLIPTASTGESKVFYLKMKGDYHRYLAEFKTGADRKEAAEHTLLAYKAAQDIALVDLPPTHPIRLGLALNFSVFYYEILNSPERACHLAKQAFDEAIAELDSLGEESYKDSTLIMQLLRDNLTLWTSDMQDPAAGDDREGADMKVEDAEP
What are the official names of this protein?
14-3-3-like protein.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: FABF_COXBU
Sequence: MEKRRVVITGLGVVSPLGNKVSDMWQALLAGKSGVKPITRFDASSFPTQIAAEVRDFDPALVLDLKSIRKTDVFVQFAMESARQAWEDSGLEINETNAPRVGVAIGSGIGGMPWIEKNYDALLTSGPRKISPFFIPGAIINMASGMVSIKYDLKGPNISIVTACTTGLHNIGHAARMIAHNDADAMIAGGTEMASTPLGIGGFAAVRALSTRNDEPEKASRPWDKGRDGFVLGEGAACVVVEELEHAKKRNATIYAEIIGFGMSGDAYHMTRPDPEAEGFTTCMKNSLRDAGIAPERVDYINAHGTSTPAADPLEARAIKKTFGDHAYKLAVSSTKSMTGHMLGAAGALETVISVLAIRDNTAPPTINLENPDEGCDLDFVPNEAREMKIDTVMSNSFGFGGTNGTLVLSRVFD
What is the function of this protein?
Involved in the type II fatty acid elongation cycle.  Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor.  Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.
What are the official names of this protein?
3-oxoacyl-[acyl-carrier-protein] synthase 2, 3-oxoacyl-[acyl-carrier-protein] synthase II, Beta-ketoacyl-ACP synthase II, KAS II.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Protein: HTPG_PSET1
Sequence: MTAAQKETLGFQTEVKQLLNLMIHSLYSNKEIFLRELVSNASDAADKLRFLALSQGDLYQGDADLRVRISADKEANTITISDNGIGMTRDEVISSLGTIAKSGTAEFFKNLTGDQSKDSQLIGQFGVGFYSAFIVADLVTVRTRKAGETTAYEWESQGEGEYTLQEIEKEGRGTDIILHLREEEKEFADEWRLRSIVTKYSDHISTPVQMYKAEVPESEGEDGEKIPAVPGEWESINRATALWTRDKSELSDDEYKEFYKHVSLDWEDPLSWAHNKVEGKTEYTSLLYIPKKAPFDLWNRDRQSGLKLYVQRVFIMDDAEQFMPSYLRFVKGLLDSNDLPLNVSREILQDNKVTQAIRKGCTSRIIKMLERMAKNKADDYQVFWNEFGQVIKEGPAEDAANKEAICKLLRFSSTHTDSATQDVSLEQYVERMNEGQEKIYYVVADTFTAAKNSPHLEIFRKKGIEVLLLSDRVDEWMMSHLTEFADKQLQSITRGDLDLGKLDDEETKKAQEESEKEVAGLVERIKTALGDEVKEVRFTHRLTDSPACVVSDDNDMSSQMQKLMESVGQAAPEAKPVFELNPEHQLVKHLNDEQDEDKFAQWSHVLLDQALLAERGTLKDPTGFVTRLNKLMLELSK
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADJ_SHEB5
Sequence: MEKTFNLTRRDDGIAILTMDVPGETMNTLKAQFGPEISEILADIKSDSSIRGLVLISGKKDSFVAGADISMLDACKTAGDAKALSQQGHVVFNELEALTIPVVAAIHGACLGGGLELALACHQRVCSDDGKTMLGVPEVQLGLLPGGGGTQRLPRLVGITTALDMMLTGKQIRPKQALKMGLVNDVVPQTILLQTAVEMALAGKRAPKPVKKSLVNQVLEGTSFGRNIIFDQATKQVEKKTQGNYPAPAKIIDCVRQGITKGMQKGLEVEASHFAELVVSKESEALRSIFFATTEMKKETGAEGASPRKVKKAVILGGGLMGGGIASVTTTKAKIPVRVKDISEKGLSNALAYAYKLLDKGVKRRHMTPAARDNLMALMTTTTEYKGVKDADIVVEAVFEDLALKHQMVKDIERECGEHTIFASNTSSLPISQIAEAATRPENVIGLHYFSPVEKMPLVEVIAHAKTSPETIATTVAFARKQGKTPIVVQDGAGFYVNRILALYMNEAAQLLLEGQSVEHLDKALVKFGFPVGPITLLDEVGIDVGAKISPILEKELGERFKAPAAFDKLLGDDRKGRKNGKGFYQYGASSKKAKAVDESVYGVLGIKPGTNKDAKALAERCVVQMLNEAVRCLDDGIIASPRDGDIGAIFGIGFPPFLGGPFHYIDTLGAANLVRILEGYQSQLGSRFEPCERLKTMAQENAHFF
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMG_SHESH
Sequence: MTTQFSVEGIELELTRYPKNQESNLQAWDAADEHLIKHLKETEQVPVATAIINDNFGALTACLRSMESQWPLAVETDAKTSQLGTVQNLENNTLSSDNIQWLNSRENIPGAIELVLMKLPKNLSYFAHQLNRLSQVLPEGTQVLIGAKAKSINKSLLELFAKNLGPASASLTWKKTRVITCTADGKVRALPTESQWSIPDLNLNITNLSNVFASGKLDIGARIMLDNMPKGDFKSIIDLGCGNGVLGLNAKQLFPQAYIHFVDDSEMAVESARQNWALNKLDTLGLVGEQATFGWDDCLTHLNEGIRPELILCNPPFHQGEAITDHIAWQMFLQSWRALKNGGILHVVGNRHLAYHVKLQRIFKNCTTVASNGKFVILQAQKISKKAEPHENGESSSDTPNPQSSLYGGVKR
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM82_VANPO
Sequence: MSLIHPIQAVVSNRSGELIFAVLKNVIIAYRYDQTNGKYLEMGKWEDQFSRDEMIKIAVVKEQARQLAENEEKGIKKSKTNEGNTIEKKHDAKIPVPGPGAPPIYSQIRNLMISNDETMLLACADSDKSVLVFKIETLNNDNCLKLIKRQPFPKRPNAITITEDDKTVIIADKFGDVYSMLIESPVIENIDEEFEPILGHVSMLTGVLSTTNNGMKFVMTSDRDEHIKISHFPQSYIVDKWLFGHKEFVSSICIPSWNSNILVSAGGDHGIFLWDWIKGEKLDEFDFTDLVLPYINENHLAPDRFQNEENDLKEFAVSKLVSLPNNPYFAFFVEATKLLIILEVDQSTYKMKLLQKIVLPYYITFISTFSDDKTMGFNISLDNRESGDKDFVKFIALDTTSNTFSIKEEQSDEFNTSIVNSFSKEDSIVKVELDEVYPLYNIISLKKHGEHYS
What is the function of this protein?
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.  In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82, Transfer RNA methyltransferase 82.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TRM82 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FOXH1_XENTR
Sequence: MRDPSSLYAGFPVGSQYESVEPPSLALLSSIYQEQVPAAPGHSYEQCAQPWPPLYREGGTWSPDRGSMHGLSPGTQEGSCTQAEGTKDSLGGDETLSRKSKKKNYHRYAKPPYSYLAMIALVIQNSPEKRLKLSQILKEVSTLFPFFKGDYMGWKDSIRHNLSSNDCFKKVLKDPGKPQAKGNFWTVDVSRIPLDAMKLQNTALTRGGSDYFVQDLAPYILHNYKYEHNVVVYAPHHMPSHASSLPLAEDPHQTNTGGKLNTSFMIDSLLNDLQDVDLPDVPRNIESQRISPAVAINNMWSSAPLLYPQSKPTRNGRGPGFSASHSTYSSSSSSISTISPVGFQETQERSEDLLGRQTQRLGFPTKRPREDDGCSTPSSDTDAGNYSPTEPPKKMPLLSLDLPTSYTKSVAPNVVAPPSVLPFFHFPRFTYYNYGPSPYMTPPYWGFPRPTNPGGDSPRGPQTSLDLDNMLKTVPPNKSVFDVLTSHPGDLVHPSFLGQCLGSSGSPYPSRQGLM
What is the function of this protein?
Transcriptional activator.  Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'.  Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 1 (ARF1), which binds a site on the mix-B/mix. 2 promoter called the activin response element (ARE).  Binds to activated smads and the ARE with much lower affinity than fast3.  Necessary for the first steps in mesoderm specification, directly inducing mesodermal genes.  Acts with fast3 to control the convergent extension movements of gastrulation.  Binds to the proximal element (PE) of the gsc gene and cooperates with gtf2ird1/wbscr11 and SMAD proteins to regulate gsc transcription (By similarity).
What are the official names of this protein?
Forkhead box protein H1, Forkhead activin signal transducer 1, Fast-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYT14_MOUSE
Sequence: MAIEGGERTCGVHELICIRKVSPEAVGFLSAVGVFIVLMLLLFLYINKKFCFENVGGFPDLGSGYNTRTNSQDKMYNSYMDRDEPGSSSESEDEALGKYHEALSRTHNSRWPLVDSRQKSYAWETRQKYSPLSAEYDGYSTEASMEDGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDAKCEISHCSNSPRCSFNKCPSEGSTGHEAESYHNKGYEDDVPSDSTAVLSPEDMSAQGSSSQLPKPFDPEPEAKYGTLDVTFDYDSERQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNPSGCDSQVSLSEASCGDSTSSCQSLQHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNTYVKLTLLNSMGQEMSKCKTSTRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNRRSMKRKEMIGWISLGLNSSGEEELRHWTAMKESKGQQVCRWHALLES
What is the function of this protein?
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.  Is Ca(2+)-independent.
What are the official names of this protein?
Synaptotagmin-14, Synaptotagmin XIV, SytXIV.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type III membrane protein.
Protein: PXPA_PARXL
Sequence: MEIDLNADLGEGCGSDEALLDLVSSANIACGWHAGGANAMRDCVRWAVQKGVSIGAHPSFNDPENFGRKEMDLPANDIYAGVLYQLGALSAIAQAEGGRVAHVKPHGALYNQAARDSRIADAIVSAVHDFDPSVAVFALANSGLVTAARNVGLIAVEEVFADRGYRADGSLVPRKEPGALLDDEDKVLARTLSMIREQRVQAVDGQWVPLNAQTICLHGDGPHALAFARRIRGALQDAGIEVHAAGAARA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: DPPA_LACLM
Sequence: MKQAKIIGLSTVIALSGIILVACGSKTSEQKNIQFSIPTDVASLDTTILTDQYSYDVAGNVEEGLTRVDSKGNAALALAKSIDVSKDGLTYTVTLKDNLKWSNGDKLTAKDFVYSWKRAVDPKTGSEYAYLMGAVSGANDIISGKSSLDTLGIKAESDTEFTVTLAQPTPYFKFLLSEPVYYPLDQKVVDKYGKQYGTSSDKTVYNGPFMFKSDKAWTGTNKNFSIYANPNYYDKSAVKSKQIDFQVISNANTGAQLYKQGKLDFTLLSTTDLINANKKTEGYTVFKQARTDYIEYNQSGKNASSPDAQKALANQDIRQALNLATNRAEVVKTALPGSTAATSFTPVGMSKTSTGEDFATYAKQDYSYDPTKAKELWAKGLKELGLTKLSLSLEAAGDLAPSEATANFLQTAYQQNLPGLTVNLKLVPFKQRLNDAQNGNFDMVLSGWGGDYAEPSTFLQLFTTGQSYNDGKFSSKTYDDAFKAATTTPDVLEPAKVDEHYKAAEAALYEGSYINPIDFQANPALMNPKITGLEFHSTGLAYDLKSAYIK
What is the function of this protein?
Part of the ABC transporter DppABCDF involved in dipeptide transport (PubMed:11409543).  Binds di- and tripeptides with high affinity.  Requires a free N-terminal alpha-amino group and an alpha-peptide bound contiguous with the N-terminal amino group, has a strong selectivity for L-residues, and shows preference for dipeptides containing methionine or arginine, followed by hydrophobic tripeptides consisting of leucine or valine residues (PubMed:10769143).
What are the official names of this protein?
Dipeptide-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 5 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PEPE_SHIFL
Sequence: MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTEKTAAVLAPLGVSVTGIHSVVDPVAAIENAEIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEAGHRF
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4031_PSEE4
Sequence: MNADTAPFWRRKTLDQLDSKEWESLCDGCGLCCLQKLEDEEDNSVYYTSIACKLLDLQTCQCSDYPNRFKHVPDCIQLTPGKADQFKWLPPTCGYRLVSEGQDLPAWHHLVSGDRTQVHEQRISRSGRMLSENDVDEDDWEDHLIFRAG
What are the official names of this protein?
UPF0260 protein PSEEN4031.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: RLMN_SOLM1
Sequence: MTNLIDLTFHELESLIVSLGEPPYRARQVWQWLWQKRCREIAGMTDVSKALRARLEEVAEIRWPVVEMVRESRDGTVKFLLALDDGERVECVLIPEKDHYTACLSTQVGCAMGCGFCATGMLGFRRNMTPGEMLGQVLVGRQYLTDKGVELGLRNLVFMGMGEPLLNYENLLKTLEALHHPQGLDFSGRRITVSTAGVARHLLDLGRTGLCSLAISLHAPTQAQRERIMPGAARLELDKLMDLLAQYPLKPRERLTFEYLLLAGVNDADADARELVRLLSRVKAKVNLIVFNATPGLPYSPPDEARVLAFQDILKSKGLTATLRKSKGSDIAAACGQLRAECDGEGEGEGK
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y103_MYCPN
Sequence: MKLSKFLIKLAMCYILIWFRHFLLSSIRIIGTTWTFWTAWFFGAFRNIWCIRIIGNRWLFRSFWSTGTLRSIFNTRILWFFRSLRFLFNYFNWWFWFILDLLKYFEPTFTLFLFGALDLKKKFNFIACKLPVLFFSNGKEFIFTHHFLNKARQQLISSKRPFVALLINELHK
What are the official names of this protein?
Uncharacterized protein MPN_103.
Protein: PDXS_FRATT
Sequence: MSDINIKIGLAEMLKGGVIMDVVNAEQAEIAQQAGAVAVMALERVPADIRKDGGIARMSDPKLIKEIMSVVSIPVMAKARIGHFVEAQILESLGVDFIDESEVLTPADELNHIDKDSFKVPFVCGCTNLGEALRRIGEGAALIRTKGEAGTGNIVEAVRQLRQVNKDINYIKNADKSELMAIAKNLQAPYDLVTYVHKNGKLPVPNFSAGGVATPADAALMMQLGAESVFVGSGIFKSADPLKRARAIVSAVTYYNDAKILAEVSEDLGEPMTGINCDFEKFSQRGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: SIR5_MOUSE
Sequence: MRPLLIAPGRFISQLCCRRKPPASPQSKICLTMARPSSNMADFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPQAFARNPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGTVAENYRSPICPALAGKGAPEPETQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELALCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETTPATDRFRFHFPGPCGKTLPEALAPHETERTS
What is the function of this protein?
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:23806337, PubMed:21908771, PubMed:22076378, PubMed:24315375, PubMed:24703693).  Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:19410549, PubMed:24703693).  Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (By similarity).  Activates SHMT2 by mediating its desuccinylation (By similarity).  Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (PubMed:24315375).  Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.  Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox (PubMed:23085393).
What are the official names of this protein?
NAD-dependent protein deacylase sirtuin-5, mitochondrial, Regulatory protein SIR2 homolog 5, SIR2-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.
Protein: PHKG1_RABIT
Sequence: MTRDAALPGSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQYVVEEVRHFSPRGKFKVICLTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLFSLAEDDY
What is the function of this protein?
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase.  In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3.
What are the official names of this protein?
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform, Phosphorylase kinase subunit gamma-1, Serine/threonine-protein kinase PHKG1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Protein: PDXT_METTH
Sequence: MIRIGILALQGDVSEHLEMTRRTVEEMGIDAEVVRVRTAEEASTVDAIIISGGESTVIGRLMEETGIKDVIIREKKPVMGTCAGMVLLADETDYEQPLLGLIDMKVKRNAFGRQRDSFEDEIDILGRKFHGIFIRAPAVLEVGEGVEVLSELDDMIIAVKDGCNLALAFHPELGEDTGLHEYFIKEVLNCVE
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: RBFA_LEUMM
Sequence: MANPQRAGRLAQEVQRDVTDLLLKRINDPRVKEVTVTSVELSGDLQIATIYYSILSDLASDAKKTQAGLEAASGLIRKELGSRLTVYKTPELKFVRDTSVQYGNHIEDLIRKLHTEN
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPC_PSE14
Sequence: MSNVLRPALSLIVLMSLITGVAYPLVVTGVAQVAFPAQANGSLVYDAAGKVRGSALIAQSFTGDEWFQSRPSAGAFATVASGASNFAPSNPALVTRVKEDVAKLANASQEPVPLALLTTSGSGLDPHLSPEAIAWQAGRVAAARQLPLEKVQALIDANTQRPLIGPPVVNVLALNMSLNQLPSAPRNAQL
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: AROA_BRUA1
Sequence: MSHSACPKPATARHSQALTGEIRIPGDKSISHRSFMFGGLASGKTRITGLLEGEDVINTGRAMQAMGARIRKEGDVWIINGVGNGCLLQPEAPLDFGNAGTGARLTMGLVGTYDMKTSFIGDASLSKRPMGRVLNPLREMGVQVEAAEGDRMPLTLIGPRTANPIAYRVPMASAQVKSAVLLAGLNTPGVTTVIEPVMTRDHTEKMLQGFGADLTVETDKDGVRHIRIVGQGKLTGQTIDVPGDPSSTAFPLVAALLVEGSEVTIRNVLMNPTRTGLILTLQEMGADIEIIDPRLAGGEDVADLRVKASKLKGVVVPPERAPSMIDEYPVLAIAASFAEGETVMDGLDELRVKESDRLAAVARGLEANGVDCTEGEMSLTVRGRPGGKGLGGGTVATHLDHRIAMSFLVMGLASEKPVTVDDSTMIATSFPEFMGMMAGLGAKIAESGAE
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL36G_MOUSE
Sequence: MFSKHPFSTHISGRETPDFGEVFDLDQQVWIFRNQALVTVPRSHRVTPVSVTILPCKYPESLEQDKGIAIYLGIQNPDKCLFCKEVNGHPTLLLKEEKILDLYHHPEPMKPFLFYHTRTGGTSTFESVAFPGHYIASSKTGNPIFLTSKKGEYYNINFNLDIKS
What is the function of this protein?
Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2.  Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity).  Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation.  May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation.  May be involved in the innate immune response to fungal pathogens.  Induces the production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23.  Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II.  Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes.
What are the official names of this protein?
Interleukin-36 gamma, Interleukin-1 family member 9, IL-1F9.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.