PharMolix/UniProtQA huggingface dataset:
Protein: COPB_TOXGO
Sequence: MELERNCMLYIYSSRGDAPSTAELQKKIESPNEATKAEGMQDLIIGMTQGEAYTRLLMTVIRYAMPSKDKRVKKLTQLYLEIVGKCRPDGSLKEEMILICNALRNDLMSPNEYVRGSTLRLLSKIRQFKVLEPLVEAILQNLTHRHSYVRRNAVMCVYSIVKNFGLDAIPATIDQIEQMLLSEGDLTTKRNAFLVLVHCASKRAIQFILQQRSEDGTGGLGFLLSSGDLFQLALLELLRKVCRQKQQQKAGLLRLIVSILPNTLPSVAYEGACSLLALSRAPVSLKAAAGAFASLLCGNSDNNVKLIVLDRLQECVQRASRRTMEEFVIDLLRGLQTPSLEVRRKILDLVLQIVGKNSVEQLLNVLKRELLRTAEPEQLTVPRTMEYRRLLIKAVHSCCTRFPEAAASVVNVLIDFPGDPDVTTATEVAVVVRELVATCVHLRSRIISRVVDAFPDSAHARVLRVSLWMLGEFCEDSELLDSFLTAVYAACSPLPFTSGDSGGAEGEQRSGCQPKLKMTTRTVVLEDGTYGTEDVYESVNEKGDSSAKAGKTALRKFILGGDFLLASTVAVTCAKLILKTSDEVHAQLAEEFERHREAVQEKAGRRTLTGDAQARETLLERQELEGKVAPVKLRASTEQKTRVLYLVACLLKFLRLSSSGAGAHSDAAIRVCQSLRALCGLMTGLEKEKAFVRHWVHHGRFALERVLALGPVSDDPFTWNLKDAEDEKTVSAPDDLAFFRQLRPDRQSLMVASEGVAAVGEDSLEEDEIYYSACAGLARGAELEEVDETEADLQLTVGGAGGTSPSLSGGNAKDDAALFQQRLAKVQPITGQADPLYVEAFLQVNQFDLLVEMLVVNRTQDSLQNVTVEPSTHGDLKLVERPAPVSLAPGQQAVLHAPIKVRSTEAGIILGYVTFSRRGSSDKECLVLNELHIDVLDYIERRWTCELAFRSMWAEFEWENKIHVNTSFTDVSEFLEHLMKMTNLTVVGFRPPASVMRRLKFSAACAGLDEAERAAGDGEEDEDRYLQSVRKIPTLRKLSESSSFFAVNLYSRSIFGEDALVNVSIEKLPGGKLAGSIRIRSRTQGIALSLGDRITVVQRGLTK
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit beta, Beta-coat protein, Beta-COP.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Apical juxtanuclear region.
Protein: PHAT1_AMAEX
Sequence: PAWLVDCPCVGDDVNRLLTRGER
What is the function of this protein?
Toxin that belongs to the bicyclic heptapeptides called phallotoxins (PubMed:24613547).  Although structurally related to amatoxins, phallotoxins have a different mode of action, which is the stabilization of F-actin (PubMed:24613547).  Phallotoxins are poisonous when administered parenterally, but not orally because of poor absorption (PubMed:24613547).
What are the official names of this protein?
Phallacidin proprotein 1.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: SSRP_ACISJ
Sequence: MAKKPDTSSRIADNKKAAYNYFFEERYEAGLVLHGWEVKALREGKVQLTDGYVIIKDGELFLIGCQINPLKTASTHVSPDAARIKKLLMHKDEIRRLIGKVEQKGYTLVPLNLHWKDGRAKCEIALAKGKAEHDKRDTIKEREGKREVERVMKSRHR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: CTU2B_XENLA
Sequence: MCEEGETYCPEVKDAKQAKSLGKICMKCKESSAALLIRAGDAFCKSCFKEYFVHKFRATLGKNRVIYPGEKVLLAYSGGPSSSAMVRQVQEGLSRDAPKKLRFVPGILFIDEGTACGMSWEERQQILSEICSVLQQTKIPFHIVSLEQVFSLPGSVLQRGAPEQRPNYKEEVDRFLVQEREQGDAGCSEMLERLEVTDSDSPGSSDKMYQSTCSRPPDMHTQKLKQLFASAKTLTAKQQLLHTLRSHLILHIARTCGYSKVMTGESCTRLSIRLLSNVSLGRGAFLPLDTGFCDSRYGDVDIIRPMREYSSKEIAYYNRFFNVLPIFIPALDTKASENSSIQHLTEVFVNRLQADFPSTVSTLYRTSEKLNVSIIDADQETCAKDRCLLCLSPLDTQAGKASAFSATQLSHHLSQKIPMKSNDLANNSDKSCCQGGQGCKEAGYGDTCQSRALQTPSFVHMLCYSCRLTVKDMQSLDVLPQYVLHEAEYRCHRTEMRKEIQEFLLEEDDGDS
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  May act by forming a heterodimer with ctu1/atpbd3 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 2-B.
What is the protein family that this protein belongs to?
Belongs to the CTU2/NCS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAMC2_MOUSE
Sequence: MPALWLSCCLGVALLLPAAQATSRREVCDCNGKSRQCVFDQELHRQTGSGFRCLNCNDNTAGVHCERCREGFYRHRDRDRCLPCNCHSKGSLSAGCDNSGQCRCKPGVTGQRCDRCQPGFHMLTDAGCTRDQGQLDSKCDCDPAGISGPCDSGRCVCKPAVTGERCDRCRPGYYHLDRANPEGCTQCFCYGHSASCHASADFSVHKITSTFSQDVDGWKAVQRNGAPAKLHWSQRHRDVFSSARRSDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRQPSAYDVILEGAGLQIRAPLMAPGKTLPCGITKTYTFRLNEHPSSHWSPQLSYFEYRRLLRNLTALLIRATYGEYSTGYIDNVTLVSARPVSGAPAPWVERCVCPAGYKGQFCQECASGYKRDSARLGPFGACVPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGFFGDPFGERGPVRPCQRCQCNNNVDPNASGNCDQLTGRCLKCIYNTAGVYCDQCKAGYFGDPLAPNPADKCRACNCSPMGSEPGECRGDGSCVCKPGFGGLNCDHAALTSCPACYNQVKIQMDQFTQQLQSLEALVSKAQGGGGGGTVPVQLEGRIEQAEQALQDILGEAQISEGAMRAVAVRLAKARSQENDYKTRLDDLKMTAERIRALGSQHQNRVQDTSRLISQMRLSLAGSEALLENTNIHSSEHYVGPNDFKSLAQEATRKADSHAESANAMKQLARETEDYSKQALSLARKLLSGGGGSGSWDSSVVQGLMGKLEKTKSLSQQLSLEGTQADIEADRSYQHSLRLLDSASQLQGVSDLSFQVEAKRIRQKADSLSNLVTRQTDAFTRVRNNLGNWEKETRQLLQTGKDRRQTSDQLLSRANLAKNRAQEALSMGNATFYEVENILKNLREFDLQVEDRKAEAEEAMKRLSSISQKVADASDKTQQAETALGSATADTQRAKNAAREALEISSEIELEIGSLNLEANVTADGALAMEKGTATLKSEMREMIELARKELEFDTDKDTVQLVITEAQQADARATSAGVTIQDTLNTLDGILHLIDQPGSVDEEGMMLLEQGLFQAKTQINSRLRPLMSDLEERVRRQRNHLHLLETSIDGILADVKNLENIRDNLPPGCYNTQALEQQ
What is the function of this protein?
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
What are the official names of this protein?
Laminin subunit gamma-2, Epiligrin subunit gamma, Kalinin subunit gamma, Kalinin/nicein/epiligrin 100 kDa subunit, Laminin B2t chain, Laminin-5 subunit gamma, Nicein subunit gamma.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
Protein: UPPS_VIBVU
Sequence: MQNSQLFTESLPKHIAIIMDGNGRWAKSKGQPRVFGHKKGVSAVRKTIAAASKLNIQAITLFAFSSENWRRPEEEVGLLMELFITVLSSEVKKLHKNNLRLRIIGDTSRFSERLQKKIVEAQELTASNTGMVINVAANYGGKWDITQAVQKVAQQVALGDLSAEDITEDDIAKHLTMSDLPEVDLLIRTSGECRISNFMLWQMAYAEMYFTPVFWPDFGEESLIEAITWFVNRERRFGCTGEQIKALMSAQ
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP).  UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
What are the official names of this protein?
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), Ditrans,polycis-undecaprenylcistransferase, Undecaprenyl diphosphate synthase, UDS, Undecaprenyl pyrophosphate synthase, UPP synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: ARGC_RHILW
Sequence: MAPKIFIDGEHGTTGLQIRTRMAGRRDVELLSIPEAERRNAAMREDMLNSADIAILCLPDDASKEAVQMVSANNNVRVIDTSTAFRVNPGWAYGFAEMDGAQADRIKAARFVANPGCYPTGAIGLIRPLRAAGLLPDGYPVTVNAVSGYTGGGKQMIAQMENPDHPDAITAPHFLYGLPLTHKHVPEMTVHGLLDRAPIFSPSVGKFAQGMIVQVPLHLGDLAEGTTMESIHAALVAHYAGQEIVTVVPLAESKALSRVNAVELEGKDTMKLFVFGTPGASQVNLVALLDNLGKGASGAAVQNMDLMLAS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IXTPA_PROM1
Sequence: MDNVPLVIASGNKGKIGEFKKLLDDFPIDLLTQPVGFEIEETGSTFMENARIKAIAVSQATGNLSLADDSGLSVEALGGAPGIYSSRYASSDKQRIEKLLAELKPFSNRKAKFECALCIASGEKVLIEVSGFCEGLITFFPKGQNGFGYDPIFEVSGLGETYAEMDHEKKKHIGHRGNAFKLLIPKLKQLLGSMKK
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: RECO_CUPMC
Sequence: MPDVRRAAAPRARSADPIAEEAAELLGSGAVPAMNAAVSPSVAAGREMMDRAMRIVPARSELRVTNEAGFVLHAHPYRETSLVLDVFTRDHGRVAMVAKGAKRPHSALRAVLQHFHPIALSWTGRGEVKTLTKAEYVGGMLPLSGDALLSGFYLNELLLRFCPREDAHPTLFRHYMATLTRLSHGEPASFVLRSFERVLLQETGFAVAFDQCLRSGERVQPGLDYVYQPERGVRRTHASDPSSWPVVSGQTLLDMAQDDYSRAQTVSQSRALMRFLLHYYLQGAPLKTRQILIDLQYL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: DMP1_RAT
Sequence: MKTVILLTFLWGLSCALPVARYQNTESESSEERTGNLAQSPPPPMANSDHTDSSESGEELGSDRSQYRPAGGLSKSAGMDADKEEDEDDSGDDTFGDEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRETQSVSTEDFRSKEESRSETQEDTAETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGDNPDNTSQTGDQRDSESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQESAQDEDSSSQEGLQSQSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSSSEEDNHPKNIEADNRKLIVDAYHNKPIGDQDDNDCQDGY
What is the function of this protein?
May have a dual function during osteoblast differentiation.  In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin.  During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).
What are the official names of this protein?
Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, AG1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity).
Protein: PSBD1_ACAM1
Sequence: MTIAVGRAQERGWFDVLDDWLKRDRFVFIGWSGILLFPCAFLSIGGWFTGTTFVTSWYTHGLASSYLEGANFLTVAVSTPADSLGHSLLLLWGPEAQGDFTRWCQLGGLWNFTTLHGVFGLIGFMLRQFEIARLVGVRPYNAVAFSGPIAVYVSVFLMYPLGQSSWFFAPSWGVTSIFRFLLFAQGFHNLTLNPFHMMGVAGILGGALLCAIHGATVENTLFEDGQDANTFAAFTPTQAEETYSMVTANRFWSQIFGIAFSNKRWLHFFMLFVPVTGLWASAIGLVGIALNMRAYDFVSQEIRAAEDPEFETFYTKNILLNEGLRAWMAPQDQIHENFIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein 1, PSII D2 protein 1, Photosystem Q(A) protein 1.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: FIBB_CAPHI
Sequence: GYLDYDEVDDNRAKLPLDAR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: MATA1_NAKDE
Sequence: MNVQEIHNIREACITILSGTKHNSVLFEPCDKFDEVINSLDIDPDSKETLRRSVSLLVGTRNHKRGCNIDKKTKDMLNKVYEQKQYLTKEEREFVAKKCNLTPLQVRVWFANKRIRNKNTKM
What is the function of this protein?
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion.  Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription of haploid-specific genes and of MATALPHA1 (By similarity).
What are the official names of this protein?
Mating-type protein A1, MATa1 transcription factor.
What is the protein family that this protein belongs to?
Belongs to the MATA1 family.
Protein: RS19G_ASCSU
Sequence: MVKATSVKDVDQHEIVQHIAKFLKKSGKVKVPEWSDVTKMGISKELAPLNSDWYYVRTASIARRLYVRSPTGVDALRLVYGGSKRRGVVPNHFAKASGSVIRKALQTLEAIKWVQKHPDGNGRVLTKQGRKDLDRIASQMRQNDRFTA
What is the function of this protein?
Elimination of the ALEP-1 gene from all somatic cells in its fully activate state may represent an alternative way to gene regulation.
What are the official names of this protein?
40S ribosomal protein S19G, Eliminated protein NO. 1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS19 family.
Protein: FABZ_BRUSI
Sequence: MSDDNQTKLEAADIQALLAVLPHRYPFLLIDRIVDIDGDVSATGIKNVTINEPHFTGHFPENPIMPGVLIVEAMAQTAGAISLLQRKTGRPGVVYFMTIDNAKFRRPVVPGDRLLLHVKKIKQRANISKYECVAEVDGVKVAEAEVAAMISVADENL
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_LACPL
Sequence: MRVKETLNLGKTKFKMRGNLPVKEVERQNVWAENKVYEQRQKLNEGKPSFILHDGPPYANGDIHMGHALNKITKDFIVRYKSMNGFRAPYVPGWDTHGLPIEQKLKQAGYDRKKMTDNEFRELCRKYALEQVDRQRDEFKRLGVAGEWDNPYLTLKPEFEAAQVRVFGAFAKRHLIYRGQKPVFWSWSSESALAEAEVEYHDVTSPSAFYGEHVIDGKGVLDDDTYMVVWTTTPWTIPASEGITIDASFDYVVVQPAGENRKFVLAAELLDENAERFGWEDVQVLKTVKGAELENILCEHPFDNSRHLVTMLGDFVTLDSGTGLVHTAPGYGEDDYRIGKQYDLPIFAPVDDKGFLTAEAGDDFAGVFYDDANKIALDKLKAAGLLLKYMPYEHSYPFDWRTKKPIIFRATPQWFASVGDMRDEILKSMDDVEFFPEWGKKRLYNMIRDRGDWVISRQRVWGVPLPIFYAEDGTAIMDEVTINHVADLFGKYGSNVWFERDAKDLLPDGYTNEHSPNGTFTKETDIMDVWFDSGSSHQGVLAERSYLDYPADLYLEGSDQYRGWFNSSLITSVAVSGHAPYKQVLSQGFTLDNQGRKMSKSLGNTIAPADVIKQMGAEIVRMWVASVDTSSDVRVSMESFKQVADSYKKFRNTVRFMLGNTADFDPKANRVAYEDLASVDQYMETRLNEFVAETKDHYDHYDFLDIYKKLINFLTVDLSNFYLDIAKDIMYIDAEDSHSRRSMQTVFYDVLVALTKLFTPMLPHTTEEIWPFLKEPEEFAQLAEMPAVQNYANSDELMAQWTRFMDLRSNVLKALEEARDAKLIGKSLEAHLDLYVDDDTQAFLDHLNTNVRQMLMVSALDLHALSDAPEDAETFGDTLAIKVGHADGDVCDRCRMVKTDVGSDEAYPMLCARCAAIVRENYPESVTTGLEA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1919_STRZJ
Sequence: MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKKGDPDPESNSALKFVIDRAKQAQVPKHIIDKAIDKAKGNTDETFTEGRYEGFGPNGSMLIVDTLTSNVNRTAANVRAAFGKNGGNMGASGSVSYLFDNKGVIVFGGEDADAVFEQLLEADVDVDDVEAQEGTITVYTAPTDLHKAIVALRESGIEEFQVTELEMIPQSEVELSGEDLETFEKLYSVLEDDEDVQKIYTNVDGF
What are the official names of this protein?
Probable transcriptional regulatory protein SPJ_1919.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family. YeeN subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FICD_DROPS
Sequence: MAMTILHASEKVNAEAEATTCPPTEKVKEEQQQQEQLQHSKTSKRVQFYRFALFFIAGSFAAFSFHALTSSSSWRLRQLHHLPNAHYLQTREEFAVYSVEELNAFKEFYDKSISDSVGASYSEAEQTNIKEALGALRLAQDMHLSGKDDKASRLFEHALALAPKHPEVLLRYGEFLEHNQRNIVLADQYYFQALTLCPSNSEALANRQRTAEVVQTLDERRLQSLDSKRDALSAIHESSSALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSILETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKLEITIKDILELHRRVLGHVDPIEGGEFRRNQVYVGGHVPPGPGDLALLMQRFERWLNSEHSSSLHPVNYAAYAHYKLVHIHPFIDGNGRTSRLLMNTLLMRAGYPPVIIPKQQRSKYYHFLKLANEGDIRPFVRFIADCTEKTLDLYLWATSDLPQQIPMLIQTESEAGEQLAQMRSPHISAQSASIPEFYEFSGSGFQP
What is the function of this protein?
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity).  The side chain of Glu-261 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity).  Acts as a key regulator of the unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of Hsc70-3/BiP.  In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of Hsc70-3/BiP at 'Thr-518', thereby inactivating it.  In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from Hsc70-3/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity).
What are the official names of this protein?
Protein adenylyltransferase Fic, De-AMPylase Fic.
What is the protein family that this protein belongs to?
Belongs to the fic family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: GYS1_MOUSE
Sequence: MPLSRSLSVSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLGEDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN
What is the function of this protein?
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
What are the official names of this protein?
Glycogen [starch] synthase, muscle.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 3 family.
Protein: ST7R_ARATH
Sequence: MAETVHSPIVTYASMLSLLAFCPPFVILLWYTMVHQDGSVTQTFGFFWENGVQGLINIWPRPTLIAWKIIFCYGAFEAILQLLLPGKRVEGPISPAGNRPVYKANGLAAYFVTLATYLGLWWFGIFNPAIVYDHLGEIFSALIFGSFIFCVLLYIKGHVAPSSSDSGSCGNLIIDFYWGMELYPRIGKSFDIKVFTNCRFGMMSWAVLAVTYCIKQYEINGKVSDSMLVNTILMLVYVTKFFWWEAGYWNTMDIAHDRAGFYICWGCLVWVPSVYTSPGMYLVNHPVELGTQLAIYILVAGILCIYINYDCDRQRQEFRRTNGKCLVWGRAPSKIVASYTTTSGETKTSLLLTSGWWGLARHFHYVPEILSAFFWTVPALFDNFLAYFYVIFLTLLLFDRAKRDDDRCRSKYGKYWKLYCEKVKYRIIPGIY
What is the function of this protein?
Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).  Lesions in the gene coding for the enzyme cause dwarfism.
What are the official names of this protein?
7-dehydrocholesterol reductase, 7-DHC reductase, Protein DWARF 5, Sterol Delta(7)-reductase.
What is the protein family that this protein belongs to?
Belongs to the ERG4/ERG24 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YPUA_BACSU
Sequence: MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDKQKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVETHNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISEDVKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDLNVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVIDFFVSIWNAIVSIFK
What are the official names of this protein?
Uncharacterized protein YpuA, ORFX19.
What are the subcellular locations of this protein?
Cell membrane. Membrane raft. Note=Present in detergent- resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Protein: MOS_MSVTS
Sequence: MPSPLSLCRYLPRELSPSVDSRSCSIPLVAPRKAGKLFLGTTPPRAPGLPRRLAWFSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQSPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSGEPQYVQYAVVAYNLRPSLTGAVFTASLTRKTLQNIIQNCWEARALQRPGAELLQRDLKAFRGALG
What are the official names of this protein?
Serine/threonine-protein kinase-transforming protein mos.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.