PharMolix/UniProtQA huggingface dataset:
Protein: THA_APTPA
Sequence: MEQKPSTLDPLSEPEDTRWLDGKRKRKSSQCLVKSSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDGCCVIDKITRNQCQLCRFKKCISVGMAMDLVLDDSKRVAKRKLIEENRERRRKEEMIKSLQHRPNPSAEEWELIHVVTEAHRSTNAQGSHWKQKRKFLPEDIGQSPMASMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGKSLSAFNLDDTEVALLQAVLLMSSDRTGLICVEKIEKCQETYLLAFEHYINYRKHNIPHFWPKLLMKVTDLRMIRACHASRFLHMKVECPTELFPPLFLEV
What is the function of this protein?
Nuclear hormone receptor that can act as a repressor or activator of transcription.  High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
What are the official names of this protein?
Thyroid hormone receptor alpha, Nuclear receptor subfamily 1 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL18_DESAP
Sequence: MLNKTSRKEQRERRRIRVRKKITGTRECPRLNVFRSARHIYAQLVDDERGVTLCAASTLLPELKERLGDGGGKIGVARAVGEMIAEKAKSLGIERVVFDRAGYLYHGRVKALAEGARAKGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: CMOB_SALHS
Sequence: MIEFGNFYQLIAKNHLSHWLETLPAQIAAWQREQQHGLFKQWSNAVEFLPEMTPWRLDLLHSVTAESETPLSEGQLKRIDTLLRNLMPWRKGPFSLYGVDIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHLWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALKAFDTVFSMGVLYHRRSPLEHLWQLKDQLVNEGELVLETLVVDGDENTVLVPGDRYAQMRNVYFIPSAPALKKWLEKCGFIDVRIADVCVTTTEEQRRTEWMVTESLADFLDPNDRSKTVEGYPAPQRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: SODL_CAMPM
Sequence: MAVCIIDHDNIRGVIYFEPVHGKDKVLGSVIGLKSGTYNLIIHRYGDISRGCDSIGSPEIFIGNIFVNRYGVAYVYLDTDVNISTIIGKALSISKNNQRLACGVIGISYINEKIIHFLTINENGV
What is the function of this protein?
Virion protein with no enzymatic activity.
What are the official names of this protein?
Cu-Zn superoxide dismutase-like protein.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: PHNR_SALPA
Sequence: MKSIPGDIPQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQNTNFHKLCREQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDLNGSLTEVYESYYNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHDSLRIEVDTH
What are the official names of this protein?
Putative transcriptional regulator of 2-aminoethylphosphonate degradation operons.
Protein: Y3274_BURPS
Sequence: MCHAREASPGTGEPEAAPRDNFPREAGSKRGIGAAFETRAQRFLERAGLALVARNVTVRGGEIDLVMRERDGTLVFVEVRARANSRYGGAAASIGARKRMRLLLAAHAFWARTGGANACRFDVVAFEGGRLVWLRDAFRADDAG
What are the official names of this protein?
UPF0102 protein BPSL3274.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: SSUD_RALPJ
Sequence: MQVFWFIPTHGDSRYLGTAEGARQVDHTYLQQVAVAADTLGYEGVLIPTGRSCEDPWVVAASLIPVTKRLRFLVAVRPGLMAPTLAARMAATYDRLSNGRLLVNLVTGGDPAELAGDGLFLDHAQRYEASEEFIRIWRETLAASHEGAALDYTGKHLSVKGAKVLYPPVQRPHPPVYFGGSSEAAHELAAEQVDSYLTWGEPPAAVAEKIADVRARAAKHGRTVRFGIRLHVIVRETEDEAWAAADKLISKLDDDTVARAQEAFRKMDSAGQQRMAALHANGVKRTRADLEISPNLWAGVGLVRGGAGTALVGDPQTVAARMKEYADLGIDTFVLSGYPHLEEAYRFAELVFPLLPRSVRDKLPGNVLNGPFGEVIATGIVPRVAAS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: PETN_GRATL
Sequence: MLDIISLGWGSLLAIFSFSIALVVWGRNGF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PEPT_STAAS
Sequence: MKNQLIDRLTRYTTIDTQSDPKSTTTPSTEKQWDLLHLLEKELQQLGLPTDLDENGYLFATLESNIDVDVPTVGFLAHVDTSPDFNASNVKPQIIENYDGKPYKLGNTKRVLDPKVFPELNSLVGHTLMVTDGTSLLGADDKAGIVEIMEAICYLQEHPEIKHGTIRIGFTPDEEIGRGPHKFDVDRFNADFAYTMDGSQYGELQYESFNAAEAVITCHGVNVHPGSAKNAMVNAIRLGEQFDSLLPDSEVPERTEGYEGFYHLMNFEGTVEKATLQYIIRDHDKKQFELRKKRILEIRDDINAHFENYPVKVDISDQYFNMAEKILPLPHIIDIPKRVFAKLDIPANTEPIRGGTDGSQLSFMGLPTPNIFTGCGNFHGPYEYASIDVMEKAVQVIIGIVEDIAENH
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_BARBK
Sequence: MTSHAPDPIHQFEISRLINVSIGNVDFSFTNVSFFIIATVVLSSVFLFISSSSRRLVPTRMQSISEMAYEFVASTLRESAGVQGMKFFPLVFSLFVFILVANFIGLFPYFYTITSQIMITFSLAMLVILTVIGCGFYKHGIGFLKLFVPSGVPVMILPLVTVIEVISFFSRPISLSLRLFANMLAGHITLKVFSGFIVSMVGLGFIGVGGSILPLIMTVAITALEFLVAFLQAYVFTVLTCMYLNDAVHPGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPB_RHOPB
Sequence: MSDMRLIVAGAGGRMGRALIRAITETPGAVVAGALEAPTSALLGQDAGTLAGLPPSGVKLSADLWALSAEADGIVDFTVPEATIANVAIAAQRGMVHVIGTTGLTASDDAVISSVTSRATVVKSGNMSLGVNLLAALVKRVARSLDDGFDIEIVEMHHKAKIDAPSGTALLLGEAAAAGRGVALAEHSIRGRDGVTGARKAGDIGFASLRGGTVTGDHTVIFAGPYERIELTHKAEDRMIFAHGALKAALWARDQGPGLYSMADVLGLSDI
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCAL_STAAW
Sequence: MKSVGLITEYNPFHNGHQYHINQSKKLTNADVTIAIMSGNFVMRGEPAIYNKFTRAKMALSTADLVIELPATASLSSGDHFAELAVKVADYMSVDTIAFGSENNDIKTLKQLAHSINEIEQSESFSQKVKEGKSYPRIISELLEHHEALASPNNILGISYLKAIAKNAKNINAISIKRENAQHHDSLIQHHQFASGTSIRTSIISQDDHWHHVVPKDIQHLYVTPHITLNQIFPYLKYQIIAMTTDSLKNIYTVTEGFENRLKSNIYEATDFHHFVKLLKTKRYTYTHIQRLLMNVLLNIKPTDVTSNIHAVKVLAMNDRGRQYLKHLKTAFPERQYITNINKSNAHYFTNEIKATHIYNAISGQQQTDFNTPVIQQYR
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNCB_BOVIN
Sequence: MAAEQDPEGRAAARPLLTDLYQATMALGYWRAGRAQDQAEFELFFRQCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASALPPDTDPAFFEHLRALDCSGVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPDKRLLEMGLRRAQGPDGGLTASTYSYLGGFDASSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGQGSQVDLAASVEMWLERVCGHLGLGVQEPHRGERAAFVAYALAFPRAFQGLLDTYSVRRSGLPNFLAVALALQELGYQAVGVRLDSGDLLQQAREIRGVFRTAAAQFGVPWLQSVPIAVSNNIDEEELARLAQKGSEVNVIGIGTSVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSLLLDVLQLAEEPPPQAGQELRVWPRGARESRTVRPAHVEPLLRLWVQQGQLCEPLPSLAESRAFAQQSLHRLSPAHRRLEQPALYQVALSEKLQALVDRLSARGAL
What is the function of this protein?
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.  Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase, Nicotinate phosphoribosyltransferase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: CA425_CONBU
Sequence: MGMRMMVTVFPLVVLATTVVSLRSNRASDGRRGIVNKLNDLVPKYWTECCGRIGPHCSRCICPGVVCPKRG
What are the official names of this protein?
Conotoxin Bu25.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYT_CLOPS
Sequence: MIKITLKDGSIKEVEAGLSIFEIAQSISQGLARNACCGILNGKVEDLRFIVNEDSSLEICTFDSKEGQHAFNHTASHVLAAAVKRLFPQDKLAIGPSIDNGFYYDFDTEKSFSADQLNKLEEEMKKIIKENPEIKRFELPRNEALELMKDEPYKVELINDLPEGEVISFYQIGDFVDLCAGPHLMAVKPIKAVKLLRSTGAYWKGDEKNKMLSRVYGTAFPKKSELDAYLEALEEAKKRDHNKLGRELGIFTTDENVGQGLPLLMPKGARIIQTLQRWIEDEEQRRGYVLTKTPLMAKSDLYKISGHWDHYKDGMFVLGDEEKDSEVFALRPMTCPFQYAIYNSTQHSYRDLPVRFAETSTLFRNESSGEMHGLIRVRQFTLADGHIVCTPEQLEDEFKNTVDLVKYVMETLGIADDITYRFSKWDPNNTEKYINDPEAWENTQNIMREILNHLNIDFTEADDEAAFYGPKLDIQFKNVHGKEDTIITIQIDFALAERFGMYYIDKDGEKKRPYIIHRSSIGCYERTLAMLIEKYAGALPTWIAPVQAKVLPLSDKYADYANEVVEELRRRGVRVEADHRAEKIGYKIREARLERTPYILVVGEKEAENKEVSVRSRKNGEEGAMPLADFVNRIVLEIANREN
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_SULTO
Sequence: MEEIEELIYKYALQNAYKHGGKAQDKAVVSKIFVERPDLRSRAKEISEIAKKIVEKVNSMSIQDQERELKEKYPDLLEEKKKEEPEKKTLPPIKVEGKFVTRFAPNPDGPIHLGNARAAIISYKYAEMYKGEFILRFDDTDPKVKKPIKEAYDWIRKDLKWLGIKWDKEVKASERLEFYYSMAKELISKGFAYVDTCSEEEFKKMRDASKPCPNRLKSAEDNLYLFEKMLNGEFKEGEAVVRIKTDLSLPDPSQRDWVLLRIIDVKKNPHPITGDKYWIWPTYNFASALDDHDLGITHIFRGKEHEVNAEKQKWIYNYMGWKYPYVEEFGRLRLEGFMMSKSKIRTVLEKGVSIDDPRLPTLAGLRRRGILPETIIETIITVGLKVSDATISFDNLAALNRKKLDPIAKRLMFVQQPKEFIIELSEPIRAKIPYNPSKPSEYREILVNPGDKILLDAKDAEEGAVVRLMELCNVTISGNKLIFHSKTLEDAKKLNAKIIQWVKKDEASNVEVIIPDPNEEKPPISGYGEKEIGNLKINEIVQFIRFGFVRVDNKIDNKVTVIFSHE
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_YEAST
Sequence: MLSRTIRTQGSFLRRSQLTITRSFSVTFNMQNAQKRSPTGIVLMNMGGPSKVEETYDFLYQLFADNDLIPISAKYQKTIAKYIAKFRTPKIEKQYREIGGGSPIRKWSEYQATEVCKILDKTCPETAPHKPYVAFRYAKPLTAETYKQMLKDGVKKAVAFSQYPHFSYSTTGSSINELWRQIKALDSERSISWSVIDRWPTNEGLIKAFSENITKKLQEFPQPVRDKVVLLFSAHSLPMDVVNTGDAYPAEVAATVYNIMQKLKFKNPYRLVWQSQVGPKPWLGAQTAEIAEFLGPKVDGLMFIPIAFTSDHIETLHEIDLGVIGESEYKDKFKRCESLNGNQTFIEGMADLVKSHLQSNQLYSNQLPLDFALGKSNDPVKDLSLVFGNHEST
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, mitochondrial, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=It is bound to the mitochondrial inner membrane in eukaryotic cells with its active site on the matrix side of the membrane.
Protein: COX2_ATEMI
Sequence: MAYPFQLGLQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETVWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTQELKPGELRLLEVDNRVVLPMEMTVRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMAMRPGLYYGQCSEICGSNHSFMPIVLEMVPLSYFETWSALMV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RASF9_MOUSE
Sequence: MAPFGRNLLKTRHKNRSPTKDMDPEEKEIVVWVCQDEKIVCGLTKRTTSIDVIQALLEEHEATFGEKRFLLGKASDYCIVEKWRGSERALPPLTRILKLWKAWGDEQPNMQFVLVKTDAFLPVPLWRTAETKLVQNNEKPWELSPANYMKTLPPDKQKRIVRKTFRKLAKIRQDTSSHDRDNMECLVHLIISQDHTIHQQVQRMKELDMEIEKCEAKIHLDRVGNDGANYVHEAYLMPRLSDEEQKLDIQAEINQTLEDLNDSEGMAQLEEQLQYYRALIDKLSAEIEREVKGAGIDGIEDMEGAAACELENSDLESVKCDLETSMKAGLTIHSHLSGIQREIKYSDSLLQMKAREYELLAKEFSSLHISNKDGCQGKENRGKEAEAPSSNGETPPLTQRVFNIYTNDTDSDTGISSNHSQDSETTLGDVLLLAT
What is the function of this protein?
May play a role in regulating vesicuar trafficking in cells.
What are the official names of this protein?
Ras association domain-containing protein 9, PAM COOH-terminal interactor protein 1, P-CIP1, Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor.
What are the subcellular locations of this protein?
Endosome. Note=Accumulates on perinuclear endosomes.
Protein: TSAD_CAMFF
Sequence: MILGIESSCDDSSIALMDIDNFELKKYKKITQENEHSKFGGVVPELAARLHTAAIPNLIEDVKEFFTSIKAVAVTNEPGLSVSLISGVSAARALSLALGIPLIGVNHLIGHIYSLFLDKNVVLPLGVLLVSGGHTMVLNIDESGYIKLIATTSDDSFGESFDKVAKMMDLGYPGGAIIEKLALSGDKNRFNFTVPLKHDKRLEYSFSGLKNQVRTQISKFESLSLQDKSDIASSFQYTAISHITDKLEKIFSEYKFKNFGAIGGGSANQVLRSNLEQICEKFGSNLMFAPLKFCSDNAAMIARAGVCKYKNKCFTKPLDMSINPRCKLDGANLYF
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCPA_DICDI
Sequence: MSVNLNNNKNNKNKVAIGFISGSLASICATTVTNPIELVKTRLQLQGELQLSQRIYNGVWDAFKQIYKTEGIRGLQSGLIPAYFSQATMQGIRLGSFDLISNALGAKPNQDYFFLKNLLAGATAGAIGAAAGSPFDLVKVRMQAANMYKNDPQFVGYSSSFAAFKQIIQKEGFKGLTRGMLTSAQRTAVGSAIQLSTYGSCKNLVLNFVDDGIYAYIISSMVAGFIVTFGMNPFDVARTRLYFQGKGNSHGEIYKGLMDCVYKTVKKEGFGAVYKGFWAHYLRLGPHTILTLVFWEQFKKLFSGEL
What is the function of this protein?
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.  Transports oxaloacetate and sulfate (By similarity).
What are the official names of this protein?
Mitochondrial substrate carrier family protein ucpA, Solute carrier family 25 member 35 homolog, Uncoupler protein A.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: METK_SHESR
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILAQDPKARVACETYVKTGMVLVGGEVTTSAWVDIEELTRKTVREIGYVHSDMGFDADSCAVLNAIGKQSPDINQGVDRADPKEQGAGDQGLMFGYASNETDILMPAPITYAHALVKRQSEVRKDGTLPWLRPDAKSQVTFAYEDNKIVGIDAIVLSTQHSPDIAQADLIEGVMETIIKPVLPAQWLNKDTKYFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSISVETFGTGKVSEEVLIKLVRQHFDLRPYGLTEMLNLARPIYQATAAYGHFGRNEFPWEATDKADALRADAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_ACIB3
Sequence: MSRLATRFEKLQSQQRKALVSYVMAGDPQPQVTVPLLHKMVAAGVDVIELGLPFSDPMADGPVIALAAERALAAGTNTLDALNMVKEFREQDQETPVVLMGYLNPVEVIGYEKFVSYAKQCGVDGLLLVDLPPEESKEFGAILKQHDMDQIFLLAPTSTDQRIQHVANQASGFIYYVSLKGVTGAATLDTSEAAARIEKIKGMTNVPVGVGFGISDAASAKAMGSVADAVIVGSAFVKSFATLAADEAVEQTVNKVKELRAALDELV
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RS20_NITHX
Sequence: MANTHSAKKATRKITRRTAVNKSRRTLMRGSVRIVEEAIAKGDRDAAIQAMKRAEPELMRAGQQNIVHKNSASRKVSRLTHRIAKLAK
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: ARF_RAT
Sequence: MGRRFVVTVRIRRTGRSPQVRVFLVQFLGSSRPRSANGTRGFVALVLRPERIARRGPQPHPGPGDDDGQRQSGSSPALLWCRFELRGPHHPLPTGARRSAGGLPRHSGSTAPGRGAAGCARCLGSPAARPGPRAGTSRRRAVFAVSTLLRWERFPGHRQA
What is the function of this protein?
Capable of inducing cell cycle arrest in G1 and G2 phases.  Acts as a tumor suppressor.  Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus.  This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis.  Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.  Binds to BCL6 and down-regulates BCL6-induced transcriptional repression.  Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression.  Binds to TOP1/TOPOI and stimulates its activity.  This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation.  Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing.  Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity).  Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination.  Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1.  Binds to HUWE1 and represses its ubiquitin ligase activity.  May play a role in controlling cell proliferation and apoptosis during mammary gland development (By similarity).
What are the official names of this protein?
Tumor suppressor ARF, Alternative reading frame, ARF, Cyclin-dependent kinase inhibitor 2A, p19ARF.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: RHLA_PSEAE
Sequence: MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA
What is the function of this protein?
Required for rhamnolipid surfactant production (PubMed:15126453).  Supplies the acyl moieties for rhamnolipid biosynthesis by competing with the enzymes of the type II fatty acid synthase (FASII) cycle for the beta-hydroxyacyl-acyl carrier protein (ACP) pathway intermediates.  Catalyzes the formation of one molecule of beta-hydroxydecanoyl-beta-hydroxydecanoate from two molecules of beta-hydroxydecanoyl-ACP.  Is the only enzyme required to generate the lipid component of rhamnolipid.  In vitro results establish that RhlA is highly selective for 10-carbon acyl-ACP intermediates and thus functions as the molecular ruler that controls the acyl chain composition of rhamnolipids.  Cannot use beta-hydroxydecanoyl-CoA as substrate (PubMed:18326581).  Rhamnolipid production plays an important role in swarming motility (PubMed:15126453).
What are the official names of this protein?
3-(3-hydroxydecanoyloxy)decanoate synthase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: IXTPA_ACIAD
Sequence: MSAPHWLSQGTLVLASNNKGKITEFEKLFAELQLPVDVIPQGQLNIPDAIEDGLSFVENAIIKARHASKISGKPAIADDSGICVPVLGGAPGIYSARYAGDHGNDAANNEKLLHDLKPFRNAEQAIQGMFVCVLALVEHAEDPLPQIFQGFWHGEILEQARGEHGFGYDPLFWLSELKMSSAEMSKEEKNKISHRGQAMQRFRESLMTRE
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.