PharMolix/UniProtQA huggingface dataset:
Protein: SYV_HAEPA
Sequence: DGISLEDLLEKRTGNMMQPQLAEKIAKATRKEFVDGIAAHGTDALRFTLAALASNGRDINWDMKRLEGYRNFCNKLWNASRFVLTNDKLDLSQGEIEFSVADRWIQSEFNRTVESFRSALSQYRFDLCANAIYEFTWNQFCDWYLELTKPVFANGNAAQIRAASQTLVHVLEKLLRLAHPLIPFITEEIWQKVKGFVGITADSIMLQPFPQVEENGFDPEAEAEIEWLKEVIVAVRNIRAESNIAPSKGLDLLFRNLSAENAKILEKQTALLKAMAKLDNVQVLAANETHASVAKLVGNAELLVPMAGFINKEAELARLTKEIEKYQNEVKRIENKLSNEAFVAKAPKAVITKEREKQAEYQSGLEKIQEQYKAIEAL
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity).
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX145_LYCSI
Sequence: MKFVLLFGVLLVTLFSYSSAEMLDDFDQADEDELLSLIEKEEARKDCIPKHHECTSNKHGCCRGHLFKYECQCTTVVTQSREETERCFCGTPPHHKAAELVVGFGKKIFG
What are the official names of this protein?
U1-lycotoxin-Ls1cc, Toxin-like structure LSTX-A45.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 03 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: XYN3_HYPJR
Sequence: MKANVILCLLAPLVAALPTETIHLDPELAALRANLTERTADLWDRQASQSIDQLIKRKGKLYFGTATDRGLLQREKNAAIIQADLGQVTPENSMKWQSLENNQGQLNWGDADYLVNFAQQNGKSIRGHTLIWHSQLPAWVNNINNADTLRQVIRTHVSTVVGRYKGKIRAWDVVNEIFNEDGTLRSSVFSRLLGEEFVSIAFRAARDADPSARLYINDYNLDRANYGKVNGLKTYVSKWISQGVPIDGIGSQSHLSGGGGSGTLGALQQLATVPVTELAITELDIQGAPTTDYTQVVQACLSVSKCVGITVWGISDKDSWRASTNPLLFDANFNPKPAYNSIVGILQ
What is the function of this protein?
Glycoside hydrolase involved in the hydrolysis of xylan, a major plant cell wall hemicellulose made up of 1,4-beta-linked D-xylopyranose residues.  Catalyzes the endohydrolysis of the main-chain 1,4-beta-glycosidic bonds connecting the xylose subunits yielding various xylooligosaccharides and xylose.  Produces xylobiose and xylotriose as the main degradation products.
What are the official names of this protein?
Endo-1,4-beta-xylanase 3, Xylanase 3, 1,4-beta-D-xylan xylanohydrolase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RTEL1_MOUSE
Sequence: MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAWQQHLRDAVSSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIPKIIYASRTHSQLTQVIRELRNTAYRPKVCVLGSREQLCIHPEVKKQESNHMQISLCRKKVASRSCHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGELQQEFIVDTSSSGLNMELEDIAKLKMILLRLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTNTAGLQKLMDIIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRKQGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAQLPSWVRPYLKVYDNFGHVIRDVAQFFRVAQKTMPLPVPQAVTSSVSEGEIALKDATLSSYSLSTRKAMSLDVHVPSLRQKPIGLPAAGDSESSLCGEYEQQTFSAQQRPMGLLAALEYNEQKAGASEEQALGSSTPSLRCEKRLSTEQKGGRKKVRLVNHPEEPMAGTQAGRAKMFMVAVKQALSQANFDTFTQALQHYKSSDDFEALVASLTCLFAEDPKKHTLLKGFYQFVRPHHKQQFEDICFQLTGQRCGYQPGKRELESKLTLSEGVDRQLDPGQHLNQGQPHLSAHPTSKGHTSHCTKVGCAVEKPGQPAVSDYLSDVHKALGSASCNQLTAALRAYKQDDDLDKVVAVVAALTTAKPEHLPLLQRFGMFVRRHHKPQFLQTCADLMGLPTTGKDLELEGPRDESPTVPPELTHEDLKPGPSMSKKPEKTQSKISSFFRQRPDESVRSDDTTPKPMQLPPRLPHELMKPHRSKQ
What is the function of this protein?
ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability.  Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis.  Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.  Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
What are the official names of this protein?
Regulator of telomere elongation helicase 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RAD3/XPD subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with PCNA within the replication foci in S-phase cells.
Protein: PSBB_CYACA
Sequence: MALPWYRVHTVVLNDPGRLISVHLMHTALVSGWAGSMALYELAVFDPSDPVLNPMWRQGMFVMPFMARLGVTDSWGGWSITGESVSNPGLWSFEGVALTHIVLSGLLFLASIWHWVYWDLDLFRDPRTLEPALDLPKVFGIHLVLSSLLCFGFGAFHVTGLFGPGIWISDAYGLTGRIQSVAPAWGPEGFNPFNPGGIASHHIAAGTVGILAGVFHLNVRPPQRLYRALRMGNIETVLSSSIAAVFFASFVVSGTMWYGAASTPIELFGPTRYQWDSGYFQQEIEKRVEESLSNGLSLPEAWSNIPDKLAFYDYIGNNPAKGGLFRAGPMNKGDGIAEAWLGHPVFQDKEGHELIVRRMPAFFENFPIILVDKDGIIRADIPFRRAESKYSIEQVGVTCSFYGGKLNNQSFKDASTVKKYARKAQFGEVFEFDRTILDSDGVFRSSPRGWFTFGHANFALLFFFGHLWHGSRTLFRDVFAGIGAEVTEQVEFGVFQKVGDKTTKKQGYV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: GGR2_METST
Sequence: MIETDILVVGAGPSGSLAAKEAALHGADVILIDRKSEIGSPKRCAEGVSKDGLAQLGIKPDPRWIARDLYGVRLVSPNNTSVWMDNNTIKIPEAGYILERKVFDKHMAMDAARAGAKIMIKTNATSLKRVDDGIIVSTNHMGKDIDIHAKIVIAADGPESRIGRWAGLECNTEFKYMESCIQFEMAGVNMENNRDIALFFGSVAPGGYVWIFPKGDDIANVGIGVLKNKTNKTAYEHLMEFIKTCPETKDAQPVEINVGGDPVGGIIKDRIGDNILVVGDAAGFVNSLTGGGINSALESGVYAGIVAAQAIKDGDYSKNNLKEYVSLTDEHIGKHYKKYNKAKEYLLSLEDEELDEIAEEFAKADFEEVNPRTLIKMLIKVSPKALVKLGKLF
What is the function of this protein?
Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids.  Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
What are the official names of this protein?
Digeranylgeranylglycerophospholipid reductase 2, DGGGPL reductase 2, 2,3-bis-O-geranylgeranylglyceryl phosphate reductase 2, Geranylgeranyl reductase 2, GGR 2.
What is the protein family that this protein belongs to?
Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
Protein: S22A4_MOUSE
Sequence: MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPDTVNLSSSWRNHSIPLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQLEQESCLDGWEYDKDIFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVLPLFAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAGIFDPLELQELNSLKQQKVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPEDYNFVSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIGIITLFFPESFGVTLPENLEQMQKVRGFRCGKKSTVSVDREESPKVLITAF
What is the function of this protein?
Sodium-ion dependent transporter of various organic cationic compounds.  A key substrate of this transporter is ergothioneine (ET) (By similarity).  Able to transport carnitine, probably moving one sodium ion with one molecule of carnitine (By similarity).  Also transports tetraethylammonium (TEA) without the involvement of sodium (PubMed:11010964).  Relative uptake activity ratio of carnitine to TEA is 1. 78.  May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity).
What are the official names of this protein?
Solute carrier family 22 member 4, Organic cation/carnitine transporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: MEIG1_OXYMA
Sequence: MDGLAIGGVSAPMTAERPQQVKKQLSRRTPDAADGRKPTRMERAKAWTPEIEDQFRLQNSGFKSLDEYVDMYGEPERWPNELGGFISKTQLKSNGYFVYWRKFRECEDKHLAQVKIYYYD
What are the official names of this protein?
Meiosis expressed gene 1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the MEIG1 family.
Protein: YL690_MIMIV
Sequence: MQFQSVGNCAPCKDPCPLKSFCDPGLSNTCNIQPFVNPFGPRRAVATWKVNYLISNRNVLAAHCDPDLINPWGIVIYNNQLWVVCNNTDSITNYDLFGNKLLGTISIRNASHNPSYPTGIAINCGGGFSISTGNISRGGLMLTCSEHGTCHSFNPVVDPLHSFIVLNQQITGEVSVYRGLCIANNTLYLADFFQRHIDVFDQNFNRLIGYPFVDNDGSDPIPLNYGPSNIVNIGCFLYILWAKKDPNITLYAVDEPGAGYISVFNLDGSFVRRFTSRGVLNNPWGMIPAPAECGFPPGSFLVGNHGDGRINIFDCNGRYVGPVLAMTGLPLVIDGIRGLAPHYTDFSEIYFSAACDEMTDGLVGSLVKDQVIYF
What are the official names of this protein?
Uncharacterized protein L690.
What is the protein family that this protein belongs to?
Belongs to the mimivirus R640 family.
What are the subcellular locations of this protein?
Virion.
Protein: RL2_RHOPB
Sequence: MALKKFNPTTPGQRQLVMVDRSALYKGKPVKSLTEGKHSAGGRNNTGRIVVRFRGGGHKQTYRIVDFKRTKVDMPAVVERLEYDPNRTAFIALIKYTDGTQAYILAPQRLAVGDTVLAGAYVDVKPGNVMPLGNMPIGTIVHNVELKIGKGGQIARSAGTYAQLVGRDHDYVIVRLNSGEQRLVHGRCTATIGAVSNPDHMNISIGKAGRSRWLGRKPHNRGVTMNPVDHPHGGGEGRTSGGRHPVTPWGKPTKGKKTRSNKSTNKFILISRHKRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: FAEB_EMENI
Sequence: MALLRHLLPVLTVGSAVQSAVLVQDQFQTRCENFAGKIDLPNVKVNFASYIPGSTNLTLDNVPTCDQSQVVSSDICRVAMAVTTSNASEITLEAWFPRDYTGRFLSTGNGGLGGCIQYSDLDYASRLGFATVGANNGHNGTSGEPFYKAPEVLEDFVYRSVHTGIVVGKQLTKLFYDEGFDTSYYLGCSTGGRQGFKLAQDFPGEVDGIIAGAPAINFVGLLSWSAHFYPITGPVGSATYLSLDDWDLVHEEILRQCDGLDGAEDGIIEDPDLCHPNATTLLCSPGATSGSCLTATQVNTVHEVYAPLLSSNSTLIYPRMQPGGEQFAAPAMYNGQPFQYSKDWWRYVVYSDPTWNATKWTIRDAEAALRQNPYNIQTWNADLSPLRDSGSKLLTYHGLQDQLISSDDSKLYYHRLMKTMGVTSNQLDEFYRFFQISGMAHCQDGDGAYGIGNRAETEFSTEPEDNVLMAMVRWVEEGIAPETVRGAKFSDGVGSEVEYYRKHCRYPRRNVYKGPGDYTDETAWECV
What is the function of this protein?
Involved in degradation of plant cell walls.  Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.
What are the official names of this protein?
Probable feruloyl esterase B, Ferulic acid esterase B, FAEB.
What is the protein family that this protein belongs to?
Belongs to the tannase family.
What are the subcellular locations of this protein?
Secreted.
Protein: XPA_HUMAN
Sequence: MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMANVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETIVHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
What is the function of this protein?
Involved in DNA excision repair.  Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region.  Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
What are the official names of this protein?
DNA repair protein complementing XP-A cells, Xeroderma pigmentosum group A-complementing protein.
What is the protein family that this protein belongs to?
Belongs to the XPA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDH_WOLSU
Sequence: MGIIGAGHVGSTVAFILATQGICQEIIIKDLNLDTARGIALDMGHAASATKTHTIVRVANEPSDLRGCDVVVFCAGSPRQPGMSRDDLLLANAKVIRTVLSEVKPYIQESVLVMVSNPLDAMVYTAIKESGLSPLQVLGMAGILDSARMASFIFEKLGYGSDQIVASVMGGHGDDMVPLPRYSNVAGVPITELLEPQEIEEIIHRTRNAGAEIVGYLKKGSAYFAPAKSTAIMVEAILKNSHQVFPCSVLLQGEYGYSDVVGGVPVKLGSRGVCEIIELELLHEERERFDQSIQSVKSLIDALYHHAFFVSSRP
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: SUVH3_ARATH
Sequence: MQGVPGFNTVPNPNHYDKSIVLDIKPLRSLKPVFPNGNQGPPFVGCPPFGPSSSEYSSFFPFGAQQPTHDTPDLNQTQNTPIPSFVPPLRSYRTPTKTNGPSSSSGTKRGVGRPKGTTSVKKKEKKTVANEPNLDVQVVKKFSSDFDSGISAAEREDGNAYLVSSVLMRFDAVRRRLSQVEFTKSATSKAAGTLMSNGVRTNMKKRVGTVPGIEVGDIFFSRIEMCLVGLHMQTMAGIDYIISKAGSDEESLATSIVSSGRYEGEAQDPESLIYSGQGGNADKNRQASDQKLERGNLALENSLRKGNGVRVVRGEEDAASKTGKIYIYDGLYSISESWVEKGKSGCNTFKYKLVRQPGQPPAFGFWKSVQKWKEGLTTRPGLILPDLTSGAESKPVSLVNDVDEDKGPAYFTYTSSLKYSETFKLTQPVIGCSCSGSCSPGNHNCSCIRKNDGDLPYLNGVILVSRRPVIYECGPTCPCHASCKNRVIQTGLKSRLEVFKTRNRGWGLRSWDSLRAGSFICEYAGEVKDNGNLRGNQEEDAYVFDTSRVFNSFKWNYEPELVDEDPSTEVPEEFNLPSPLLISAKKFGNVARFMNHSCSPNVFWQPVIREGNGESVIHIAFFAMRHIPPMAELTYDYGISPTSEARDESLLHGQRTCLCGSEQCRGSFG
What is the function of this protein?
Histone methyltransferase.  Methylates 'Lys-9' of histone H3.  H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3, Histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, Protein SET DOMAIN GROUP 19, Suppressor of variegation 3-9 homolog protein 3, Su(var)3-9 homolog protein 3.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
Protein: HXT4_YEAS7
Sequence: MSEEAAYQEDTAVQNTPADALSPVESDSNSALSTPSNKAERDDMKDFDENHEESNNYVEIPKKPASAYVTVSICCLMVAFGGFVFGWDTGTISGFVAQTDFIRRFGMKHHDGTYYLSKVRTGLIVSIFNIGCAIGGIILARLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVPLGLGFAWALFMIGGMTFVPESPRYLVEVGKIEEAKRSIALSNKVSADDPAVMAEVEVVQATVEAEKLAGNASWGEIFSTKTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLEDSFETSIVLGIVNFASTFVGIFLVERYGRRRCLLWGAASMTACMVVFASVGVTRLWPNGKKNGSSKGAGNCMIVFTCFYLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPFISGAIDFYYGYVFMGCLVFSYFYVFFFVPETKGLTLEEVNTLWEEGVLPWKSPSWVPPNKRGTDYNADDLMHDDQPFYKKMFGKK
What is the function of this protein?
Low-affinity glucose transporter.  Can also transport xylose (By similarity).
What are the official names of this protein?
Low-affinity glucose transporter HXT4, Low-affinity glucose transporter LGT1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BMT_GLELI
Sequence: MAGMKSSPSQDEEACVLAIQLATSTVLPMILKSAIELDILNTISKAGPGNYLSPSDLASKLLMSNPHAPIMLERILRVLATYKVLGCKRSELSNGEVEWLYCWTPVCKFLSNNEDGASIAPLLLVHQDKVPMKSWYHLTDAVLDGGTAFNKAYGMNIFDYASQDPQFNKVFNRSMAGHSTITMKKIVETYNGFEGLKSIVDVGGGSGATLNMIISKYPTIKGINFDLPHVVGDSPIHPGVEHVGGDMFASVPKGDAIFLKWIFHSWSDEDCLRILKNCYEALADNKKVIVAEFIIPEVPGGSDDATKSVVHLDAIMLAYVPGGKERTEKEFESLATRAGFKSFRKVCCAFNTWIMEFSK
What are the official names of this protein?
Bergaptol O-methyltransferase, BMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: MNMA_STRPD
Sequence: MTDNSKIRVVVGMSGGVDSSVTALLLKEQGYDVIGVFMKNWDDTDEFGVCTATEDYKDVAAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYAQVKRDENGTVYMLRGADNGKDQTYFLSQLSQEQLQKTLFPLGHLQKSEVREIAERAGLATAKKKDSTGICFIGEKNFKQFLSQYLPAQKGRMMTIDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNQPWFVVGKDLSQNILYVGQGFYHEALMSNSLDASVIHFTREMPEEFTFECTAKFRYRQPDSQVTVHVREDKAEVVFAEPQRAITPGQAVVFYDGKECLGGGMIDMAYKNGQPCQYI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RB11B_MOUSE
Sequence: MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQRPNKLQCCQSL
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel.  May also regulate constitutive and regulated secretion, like insulin granule exocytosis.  Required for melanosome transport and release from melanocytes.  Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
What are the official names of this protein?
Ras-related protein Rab-11B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
Protein: RIBA2_ARATH
Sequence: MASLTLRCDSTHLLPSRDVVKGTKPFGTSLVYPRIISKKFNVRMRVIPEEGDVFSSSKSNGSSMGIELQPDLVSFGTLAAEMIPTTMDSPEVEDEEFDLDRPTDGFASIPQAIEDIRHGKMVVVVDDEDRENEGDLIMAASLATPEAMAFVVKHGTGIVCVSMKGEDLERLELPLMVTRKDNEEKLRTAFTVSVDAKKGTSTGVSARDRAQTILTLASKDSKPEDFNRPGHIFPLRYREGGVLKRAGHTEASVDLTVLAGLEPVSVLCEIVDDDGSMARLPRLRQFAQENNLKLISIADLIRYRRKRERLVEFTAVAPIPTMWGPFKAHCFKSLLDGVEHIAMVKGEIGDGKDILVRVHAECITDDIFGNSSGGKQLAIAMRLIEENGRGVFVYLRGPESKGIDLSHKPRTYNTNSDQAEGVSFPVASREYGIGAQILRDLGVREMKVMTNNPAHYVGLKGYGLSISGKVPLITTP
What is the function of this protein?
Involved in riboflavin biosynthesis.  Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.  RIBA2 and RIBA3 together are not able to complement the loss of function of RIBA1.
What are the official names of this protein?
Monofunctional riboflavin biosynthesis protein RIBA 2, chloroplastic.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: E4PD_ECO55
Sequence: MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_ACIC1
Sequence: MTDEPLVLGIETSCDETGVGVVRGRTLLANEIASSVDLHARFGGVVPEVASRAHLEALVPTMHRALEKAGLRLADVDAIAVTAGPGLAGTLLVGVAAAKAYALALGKPLFGVNHLAAHVAVDILEHGPLPRPCVALLVSGGHSSLLLVEDVTGTVRPLGSTVDDAAGEAFDKVARVLGLPFPGGPPIDRAAQEGDPQFVAFPRGKADDGTFDFSFAGLKTAVARWVEKRERDGEPVPVADVAAAFQEAVADVLTAKAVAACRTYGVGDLLIGGGVAANSRLRSLAAERCEAAGIRLRVPRPGLCTDNGAMVAALGACLIKAGRTPSEPEFPADSSLPITEVLV
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_BORAP
Sequence: MFKVIKCNELNEKLINKKVEINAWVKKIRHHGKFTFLDIRDRYEKAQVLITEEHLLKIVEKIKLEYCIKIQGLLIKRPSNMINANMTTGYFEILAKNIEIISKCNELPFMIEDDNNASENSKLKYRYLDLRRDSLKNKIILRCQATHLIRNFLVKRKFLELETPTFVKSTPEGARDFVIPSRIHKGSFYALPQSPQLYKQLIMIAGFDKYFQIARCYRDEDSRGDRQPEFTQLDLEMSFVKKENIFKLIENMLFSIFKNCLNIKLSKKFKKITYKTAMNKYGSDKPDTRFELTLQDISRNLKNSEFNVFKDILNNKGSIKTLIVKDKADTFSRAKINNLEEIAKLYKTQGLYFTKIENNKFSGGIAKFLKTEEQQLIKAYSLENNDIIFFIANNKWEIACKAMGQIRIKIANDLGLIDENKFEFLWVYDFPLFEYDENTKTYIPAHHMFSIPKKRYISNLEKNPNKAIGEIYDLVLNGVELGSGSIRIHNKELQQRIFNIIGFQKEKSEDRFGFFLKALEYGAPNHGGIAIGIDRLIMLMTKSTSIKDVILFPKNSFAASPLDNSPSKISNEQLKELGINIAPDDT
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.