PharMolix/UniProtQA huggingface dataset:
Protein: LEXA_PSEPU
Sequence: MLKLTPRQAEILAFIKRCLEDNGFPPTRAEIAQELGFKSPNAAEEHLKALARKGAIEMTPGASRGIRIPGLEAKAEEAGLPIIGRVAAGAPILAEQHIEQSCNINPAFFHPQADYLLRVHGMSMKDVGIFDGDLLAVHTCREARNGQIVVARIGDEVTVKRFKREGSKVWLLAENPEFAPIEVDLKEQELVIEGLSVGVIRR
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: Y548_RICPR
Sequence: MNIKDIGVIISKKPLKENTFIIRVFTKNHGLYSGVIKESSKKNKFIYQEGNIVDFLWKARLHEHIGIAKCELIKSYTGYFIINKAKLYAFNSVISLIQELFHEREEHSIFFFISN
What are the official names of this protein?
Uncharacterized protein RP548.
Protein: NORB_STUST
Sequence: MSSFNPHLKFQSQAVAKPYFVFALILFVGQVLFGLIMGLQYVVGDFLFPLLPFNVARMVHTNLLIVWLLFGFMGAAYYLIPEESDCELHSPKLAIILFWVFAAAGVLTILGYLFVPYAALAEMTRNDLLPTMGREFLEQPTITKIGIVVVALGFLYNIGMTMLKGRKTVVSTVMMTGLIGLAVFFLFAFYNPENLSRDKFYWWFVVHLWVEGVWELIMGAMLAFVLIKVTGVDREVIEKWLYVIIAMALITGIIGTGHHFFWIGAPTVWLWVGSIFSALEPLPFFAMVLFALNMVNRRRREHPNKAASLWAIGTTVTAFLGAGVWGFMHTLAPVNYYTHGSQLTAAHGHLAFYGAYAMIVMTMISYAMPRLRGLGEAPDARAQRIEVWGFWLMTISMIAITLFLTAAGVVQIWLQRIPADGAAMSFMNTADQLAIFFWLRFIAGVFFLIGLVCYLYSFRQRGRVPVVVAAPAAA
What is the function of this protein?
Component of the anaerobic respiratory chain that transforms nitrate to dinitrogen (denitrification).  NorB is the catalytic subunit of the enzyme complex.  Shows proton pump activity across the membrane in denitrifying bacterial cells.  The mononitrogen reduction is probably coupled to electron transport phosphorylation.
What are the official names of this protein?
Nitric oxide reductase subunit B, NOR large subunit, Nitric oxide reductase cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
Protein: YIDC_SALPK
Sequence: MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQTQQTTQTTTTAAGSAADQGVPASGQGKMITVKTDVLDLTINTRGGDVEQALLPAYPKELGSNEPFQLLETTPQFIYQAQSGLTGRDGPDNPANGPRPLYNVEKDAFVLADGQNELQVPMTYTDAAGNTFTKTFVFKRGDYAVNVNYSVQNTGEKPLEVSTFGQLKQSVNLPPHRDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIADNENLNVSSKGGWVAMLQQYFATAWIPRNDGTNNFYTANLGNGIVAIGYKAQPVLVQPGQTGAMTSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLMGSIELRHAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKKS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTH_LISMH
Sequence: MKLIAGLGNPGKKYERTRHNVGFMVVDELSFRHQTPWKKSKFNGMTSEIIVGGEKMILVKPLTFMNASGECIRPLMDYYNIPIEDVVIVYDDLDLPVGKIRLRQKGSAGGHNGMKSIIQHVKTQEFNRIRVGVSRPLKGEVIHYVLGDFPKAEQPDIIAAIQKSADAIEDYAQTPFIEVMNKYNQK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K1A_THAAS
Sequence: MKFQMIAAVLLIAFCLSVVVTARMELQDDEEMKNGSFQKRRTCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
What is the function of this protein?
Inhibits voltage-gated potassium channels (Kv) with higher potency for Kv1. 1/KCNA1 and Kv1. 3/KCNA3 (IC(50)=3. 4 nM).
What are the official names of this protein?
Kappa-thalatoxin-Tas2a, Kappa-TATX-Tas2a, Kappa1.3-thalatoxin-Ta1a, Kappa1.3-TATX-Ta1a, Kappa1.3-TLTX-Ta1a, Potassium channel peptide toxin ta-k, TaK.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 1 potassium channel toxin family. Type 1a subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: NRDR_BURA4
Sequence: MRCPFCRHEDTQVVDSRVSEDGAAIRRRRRCSACDKRFTTYERVELNLPAVVKKDGSRTEFDRRKIVASMQLALRKRPVAADAIDAAVARIEYQLLATGEREVRSEKLGELVMNELRGLDTIAYVRFASVYRRFEDVSEFADVIEEFRRASPSKPSRKR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PTH_RUBXD
Sequence: MGLGNPGRRYALTRHNAGHMVLDELFRRHGGRWRRARRAEAAEVSVEGREAVLLKPATFMNESGEALSGYRAEDLIVVHDDLDLPAGTVRVKVGGGAGGHNGLRSVISRVGNGFVRVRVGIGRPPEGADVTGYVLGRMDRAAREAIPRAADAVEAVLEEGPEAAMNRFNARA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AF1L2_HUMAN
Sequence: MERYKALEQLLTELDDFLKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKVTINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMIPERKQLAIPKTESPEGYYEEAEPYDTSLNEDGEAVSSSYESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQLCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRFNCQKPDIAEKYLSASEYGSSVDGHPEVPETKDVKKKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSCIVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYDDVDLSELTAAVEPTEEATPVADDPNERESDRVYLDLTPVKSFLHGPSSAQAQASSPTLSCLDNATEALPADSGPGPTPDEPCIKCPENLGEQQLESLEPEDPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRLRVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSIMEVKDNLKKAEAGPVTLGTTVDTTHLENVSPRPKAVTPASAPDCTPVNSATTLKNRPLSVVVTGKGTVLQKAKEWEKKGAS
What is the function of this protein?
May play a role in a signaling cascade by enhancing the kinase activity of SRC.  Contributes to SRC-regulated transcription activation.
What are the official names of this protein?
Actin filament-associated protein 1-like 2, AFAP1-like protein 2.
Protein: VG096_BPPF1
Sequence: MAASPYYLRQTHAPDCACSVCWSVRQAIPLHNPSPCPDCRPPGLPYLEGGRWLCRPRSFCAKHDPSRRPPKYWHVVYDSGKPTPFVPVREDFQLEG
What are the official names of this protein?
10.9 kDa protein, ORF 96.
Protein: PYRF_SORMK
Sequence: MSTTQQPHWSLQKSFAERVESSSHPLTSYLFRLMEVKQSNLCLSADVEHARELLALADKIGPSIVVLKTHYDLITGWDYHPHTGTGAKLAALARKHGFLIFEDRKFVDIGSTVQKQYTAGTARIVEWAHITNADIHAGEAMVSAMAQAAQKWRERIPYEVKTSVSVGTPVADQFADEEAEDQVDELRKIVPRENSTSKEKDTDGRKGSIVSITTVTQTYEPADSPRLAKTISEGDEAVFPGIEEAPLDRGLLILAQMSSKGCLMDGKYTWECVKAARKNKDFVMGYVAQQNLNGITKEDLAPGYEDGETSTEEEAQADNFIHMTPGCKLPPPGEEAPQGDGLGQQYNTPDNLVNIKGTDIAIVGRGIITASDPPAEAERYRRKAWKAYQDRRERLA
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase, Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family.
Protein: RS4_SULTO
Sequence: MGDPKKSRRKWEGPGHPWIRINLEKEQVLIGKYGLRNKRELWLAQTIIRKFRHQARSLLALPPAERSTREKQLIQKLYRMGIIEKDNATLDDILGLNEENYLERRLQTIVYKKGLARTIYQARQLIVHGHIAIGGRRVTSPGYIVMRGEEDLIDFYPTSPFKQHPPTQQGEENVQQA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: TERT_EUPAE
Sequence: MEVDVDNQADNHGIHSALKTCEEIKEAKTLYSWIQKVIRCRNQSQSHYKDLEDIKIFAQTNIVATPRDYNEEDFKVIARKEVFSTGLMIELIDKCLVELLSSSDVSDRQKLQCFGFQLKGNQLAKTHLLTALSTQKQYFFQDEWNQVRAMIGNELFRHLYTKYLIFQRTSEGTLVQFCGNNVFDHLKVNDKFDKKQKGGAADMNEPRCCSTCKYNVKNEKDHFLNNINVPNWNNMKSRTRIFYCTHFNRNNQFFKKHEFVSNKNNISAMDRAQTIFTNIFRFNRIRKKLKDKVIEKIAYMLEKVKDFNFNYYLTKSCPLPENWRERKQKIENLINKTREEKSKYYEELFSYTTDNKCVTQFINEFFYNILPKDFLTGRNRKNFQKKVKKYVELNKHELIHKNLLLEKINTREISWMQVETSAKHFYYFDHENIYVLWKLLRWIFEDLVVSLIRCFFYVTEQQKSYSKTYYYRKNIWDVIMKMSIADLKKETLAEVQEKEVEEWKKSLGFAPGKLRLIPKKTTFRPIMTFNKKIVNSDRKTTKLTTNTKLLNSHLMLKTLKNRMFKDPFGFAVFNYDDVMKKYEEFVCKWKQVGQPKLFFATMDIEKCYDSVNREKLSTFLKTTKLLSSDFWIMTAQILKRKNNIVIDSKNFRKKEMKDYFRQKFQKIALEGGQYPTLFSVLENEQNDLNAKKTLIVEAKQRNYFKKDNLLQPVINICQYNYINFNGKFYKQTKGIPQGLCVSSILSSFYYATLEESSLGFLRDESMNPENPNVNLLMRLTDDYLLITTQENNAVLFIEKLINVSRENGFKFNMKKLQTSFPLSPSKFAKYGMDSVEEQNIVQDYCDWIGISIDMKTLALMPNINLRIEGILCTLNLNMQTKKASMWLKKKLKSFLMNNITHYFRKTITTEDFANKTLNKLFISGGYKYMQCAKEYKDHFKKNLAMSSMIDLEVSKIIYSVTRAFFKYLVCNIKDTIFGEEHYPDFFLSTLKHFIEIFSTKKYIFNRVCMILKAKEAKLKSDQCQSLIQYDA
What is the function of this protein?
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes.  It elongates telomeres.  It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
What are the official names of this protein?
Telomerase reverse transcriptase, Telomerase catalytic subunit, Telomerase subunit P123.
What is the protein family that this protein belongs to?
Belongs to the reverse transcriptase family. Telomerase subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: RNJ2_STAAS
Sequence: MSLIKKKNKDIRIIPLGGVGEIAKNMYIVEVDDEMFMLDAGLMFPEDEMLGIDIVIPDISYVLENKDKLKGIFLTHGHEHAIGAVSYVLEQLDAPVYGSKLTIALIKENMKARNIDKKVRYYTVNNDSIMRFKNVNISFFNTTHSIPDSLGVCIHTSYGAIVYTGEFKFDQSLHGHYAPDIKRMAEIGEEGVFVLISDSTEAEKPGYNTPENVIEHHMYDAFAKVRGRLIVSCYASNFIRIQQVLNIASKLNRKVSFLGRSLESSFNIARKMGYFDIPKDLLIPITEVDNYPKNEVIIIATGMQGEPVEALSQMAQHKHKIMNIEEGDSVFLAITASANMEVIIANTLNELVRAGAHIIPNNKKIHASSHGCMEELKMMINIMKPEYFIPVQGEFKMQIAHAKLAAEAGVAPEKIFLVEKGDVINYNGKDMILNEKVNSGNILIDGIGIGDVGNIVLRDRHLLAEDGIFIAVVTLDPKNRRIAAGPEIQSRGFVYVRESEDLLREAEEKVREIVEAGLQEKRIEWSEIKQNMRDQISKLLFESTKRRPMIIPVISEI
What is the function of this protein?
An RNase that has 5'-3' exonuclease and possibly endoonuclease activity.  Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity).
What are the official names of this protein?
Ribonuclease J 2, RNase J2.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_CLOPS
Sequence: MANFRGKRINEEVRKEVSDIIRNQIKDPRLTAMVSVTQVEVTKDLRYAKVFVSLFAKNDEEKEESLKALKSSAGFIRREVGNRVKLRSTPEILFEEDNSIDNAMYIESLLNKIKEK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICOS_BOVIN
Sequence: MKSDLRYFFLFCIQVEILAGEFNDSAASEMFIFHNGGVQILCKYPDTVRQFKMQLLKGDNVLCDLTKTKENEDTVSIRNLNVCKFQLSNNSVSFFLYNLDSSYASYYICKLSIFDPPPFQVDILSREYLNIYESELCCQLKFWLPIGCAAFVTVCVFGCVLMYWLTKKKYPTSVHDPNSEYMFMAAVNTAKKPAPTDVTRNLELPGTQA
What is the function of this protein?
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.  Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens.  Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10.  Prevents the apoptosis of pre-activated T-cells.  Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
What are the official names of this protein?
Inducible T-cell costimulator.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MRAY_SHESW
Sequence: MLVYLAEYLTRFYTGFNVFSYVTFRAILGLLTALIFSLWWGPKLIERLQLLQIGQVVRNDGPESHFSKRGTPTMGGLLILAAIFISVLLWGDLGSRYVWVMLFVLGSFGLIGFIDDYRKVVRKDTKGLIARWKYILQSLAALLIAFFLYATAANPGETQLVVPFFKDVMPQLGGVFIVLAYFTIVGSSNAVNLTDGLDGLAIMPTVMVAAAFALIAYLSGHVQFANYLHIPHLPGSGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLSLGAALGAIAVLVRQEILLVIMGGVFVMETVSVILQVGSYKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISIFLVLLGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y260_METJA
Sequence: MVVLFLIWSHVNVVVSDSMYPIMKRGDLVIVENAGFEFNPNDVDVGDIVVYKAHWPYYQYLLSEIDYKLNLNPYTTLYIFKEGDFKDMSVKVLGEIKTDKSSYKILEADIPKSPTKPVIHRVIDKVEFNNKTYFIIKGDNNPIHDPELVSINQIKQRVIVVDGHPLVIPYVGYLSIWLKEYWYLVVLFVLIYYAYNYLKGGRK
What are the official names of this protein?
Uncharacterized protein MJ0260.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NUSG_STRGB
Sequence: MSDPNLNDDATEPRGLAADTADDELDIVEAADEQDEFEAAEAEAGEPAEVAALHIEDEGDHIAETDEDIEAGAVETDEDVETDTDEDVEAGTDEDVAVAEAAEEEPAAPVDSIQALREELRTLPGEWYVIHTYAGYENRVKTNLEPRAVSLNVEDYIFQAEVPQEEVVQIKNGDRKTIKQNKLPGYVLVRMDLTNESWGVVRNTPGVTGFVGNAYDPYPLTLDEIVKMLAPEAEEKAARAEGKPAPQRKVEVQVLDFEVGASVTVTDGPFATLQTINEIKSDSKKVKGLVEIFGWETPVELSFDQIQKN
What is the function of this protein?
Participates in transcription elongation, termination and antitermination.
What are the official names of this protein?
Transcription termination/antitermination protein NusG.
What is the protein family that this protein belongs to?
Belongs to the NusG family.
Protein: MTGA_NEIG1
Sequence: MFRIVKWLIALPVGIFIFFNAYVYGNIITYRAVAPHRTAFMSMRMKQFEQEGRDVALDYRWVPYNRISTNLKKALIASEDVRFAGHGGFDWDGIQNAIRRNRNSGEVKAGGSTISQQLAKNLFLNESRNYLRKGEEAAITAMMEAVTDKNRIFELYLNSIEWHYGVFGAEAASRYFYKKPAADLTKQQAAKLTALVPAPLYYADHPKSKRLRNKTNIVLRRMGSAELPESDTD
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CRP_RABIT
Sequence: MEKLLWCFLTLVSFSNMSDQAGMHKKAFVFPKESDNSYVSLNAQLKKPLKAFTVCLYFYTDLSMTRGYSIFSYATRRQFNEILLFWSKDIGYSFSVGGDEIIFKVSDIPVDPTHLCASWESSTGIAELWVDGKPMVRKSLKKGYILGPEASIILGQDQDSFGGSFEKQQSLVGDIGNVNMWDYALSPEEINTIYAGGTFSPNVLDWRELTYQVRGEVHVKPQLWP
What is the function of this protein?
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine.  Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).
What are the official names of this protein?
C-reactive protein.
What is the protein family that this protein belongs to?
Belongs to the pentraxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SEPS_METTP
Sequence: MKFDPAEIREAAEKDFDGTWKRGVDYLERPSLERIYPRRSYPHGRPHPVFETIQRLREAYLRMGFTEMMNPVIVDAQEVHRQFGSEALAVLDRCFYLAGLPRPDIGISESRLSEISSIVGKELTAEEIEALREILHSYKKGAVEGDDLVPEISKAINASDSQVSMMLESVFPEFRELRPEPTSRTLRSHMTSGWFISLSNLWYRMPLPVRLFSVDRCFRREQSEDAARLMSYHSASCVVMDEDMSVDEGKAISEGLLSQFGFENFRFRPDEKRSKYYIPGTQIEVYAYHPGLVGSETKYGSGWVEIATFGVYSPTALAQYDIPYPVLNLGLGVERLAMILYGSKDLRALSYPQLQPDWSLKPIEIARMIHVDKSPMTVTGKEIARSVVETCVKYGNTPSPCEFDAWEGELFGRRIKVSVVEPEENTKLCGPAYLNEIVVYRNEILGIPRTPKWEAAFEEGVQTGIRFIDAFAELAAHEIEMATIEGRGSETRVRIVRTAGEINVRIDPALERYITSYKKRIDIRGPVFTTVRSELMQGDKHGEKT
What is the function of this protein?
Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
What are the official names of this protein?
O-phosphoserine--tRNA(Cys) ligase, O-phosphoserine--tRNA ligase, Non-canonical O-phosphoseryl-tRNA(Cys) synthetase, O-phosphoseryl-tRNA(Cys) synthetase, SepRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
Protein: ISPH_RHILW
Sequence: MNIAAKPPLTIRLCGPRGFCAGVDRAIQIVVLALKSYGAPVYVRHEIVHNRYVVEGLEAKGAVFVEELDEIPAEHRAQPVVFSAHGVPKSVPEDAVSRNLFYLDATCPLVSKVHKQAMRHNRLGRHVVLIGHAGHPEVIGTMGQLPEGSVSLIETIEDADAYIPVDADNLGYVTQTTLSVDDTAGVIARLQERFPNLTAPAADSICYATTNRQEVVKQAAPGCDLFIIVGAPNSSNSKRLVEVALRAGAKKSILVQRAAELDWDEIGAISTLGLSAGASAPEVIVNEIIEAFRARFDARVELAETVQETENFLVNRELRSIELTAADMAFVNG
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: APCD1_CHICK
Sequence: MFVPYGSLMRYLFPALLLHGLGEGSALLHPDSRSHPRSLEKSAWRAFKESQCHHMLKHLHNGARITVQMPPNIEGHWVSTGCEVRAGPEFITRSYRFYHNNTFKAYQFYYGGNRCTNPIYTLVIRGKIRLRQASWIIRGGTEADYQLRNIQIISHNEAVAKKLSELVNNTCPGFIPEDSPWEQDVSYDLLREENGCECTKALNFAMHELQLIRVEKQYLHHNLDHLVEELFLGDIHTDATQRRYYRPSSYQPPLQNAKNHDRTCIACRIIYRSDEHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPICKHPTFTIYAKGRYSRGVHSAKVMGGTEFVFKVNHMKVTPMDVSTASLLNVFNGNECGAQGSWQVGVQQDVTHTNGCIALGIRLPHTEYEIFKMEQDARGRYLLYNGQRPSDGSSPDRPEKRATSYQMPLIQCASSVPRSEESPEENKIRLYSSRAPAKHPSASALALVLFICTVSYWDILS
What is the function of this protein?
Negative regulator of the Wnt signaling pathway.  Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin.
What are the official names of this protein?
Protein APCDD1, Adenomatosis polyposis coli down-regulated 1 protein homolog, cAPCDD1, Protein primglo1.
What is the protein family that this protein belongs to?
Belongs to the APCDD1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: BMI1A_XENLA
Sequence: MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRADKTLQDIVYKLVPGLFKGEMKRRRDFYAAHPSADVANGSNEDRGEVADEDKRIITDDEIISLSIEFFDQNKADRKGSKDKDKEKSKDEINDKRYLRCPAALTIMHLRKFLRSKMDIPSNFQIDVMYEEEALKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRVKINPHTDRINHTSGDMESDSGSDKAGSLGVVIPSTSSCIPSPPVQSPHPHFPHISSTINGTSSSSSSHQNPFTNRARKISLNGVSAISSG
What is the function of this protein?
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.  In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2 (By similarity).
What are the official names of this protein?
Polycomb complex protein BMI-1-A, Polycomb group RING finger protein 4-A.
What are the subcellular locations of this protein?
Nucleus.
Protein: KDSA_BURO1
Sequence: MKLCDFEVGLDQPFFLIAGTCVVESEQMTIDTAGRLKEICEKLNVPFIYKSSYDKANRSSGKSFRGLGMDEGLRILGEVKRQLGLPVLTDVHSIDEIEQVASVVDVLQTPAFLCRQTDFIHACARSGKPVNIKKGQFLAPHDMKNVIDKARDAARDAGLSEDRFMACERGVSFGYNNLVSDMRSLAIMRETNAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAVATGVAGLFMETHPNPAEAKSDGPNAVPLNRMGALLETLVTLDQAVKRNPFLENDFN
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
Protein: MUTS_CERS4
Sequence: MSDDTVTPMMAQYLEIKAQNPGAILFYRMGDFYEMFFDDAALAAEALDIALTKRGKHRGEDIAMCGVPIHAAEGYLLTLIRKGFRVAIAEQMEDPAEAKKRGSKSVVRREVVRLVTPGTLTEDTLLEARRHNYLCAFAEIRDEAALAWADISTGELSVTACPLPRLMPELARLAPRELLVADERELDWIEEVGCALTPLSRASFDSASAEKRLCALFGVGTLESFGNFTRAELSAMGALVDYLDLTQRGKLPLLRPPVRETVGGTVQIDAATRRNLEITQALAGGRDGSLLSAVDRTVTAPGARLLERRLSSPTRDLGLIHERLGAVRWLTEEPRLREEMRASLRRVPDMDRALSRLALDRAGPRDMAAIRAGLAQAQEIAQRMPAEAPALVTRALEALGGHEALVDLLDQALVAEPPLLARDGGFIAQGFDADLDETRRLRDEGRGVIASMQAGFIEVTGIQSLKIKHNNVLGYFIEVTSTHAEKMLSAPLSERFIHRQTTAGQVRFTTVELSELETRILNAGNRALDLEKMHFAALRTAILDLAGQIGRAARSLAELDLISAFADLAVTEDWTEPEIDDSRAFAIEAGRHPVVERALRRTGTPFVANHCDLSTGETPAVWLITGPNMAGKSTFLRQNALIALLAQAGSFVPARRAHIGLVSQIFSRVGASDDLARGRSTFMVEMVETAAILNQADDRALVILDEIGRGTATWDGLSIAWATLEHLHDRNRCRALFATHYHEMTALAGKLKGVENATVAVKEWEGDVIFLHEVRRGAADRSYGVQVARLAGLPASVIERARTVLDALESGERESGGRRQTLIDDLPLFRAAPPPPAPAAPKTSPVEERLREIQPDDLSPREALKLLYDLRALLT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: GORAB_DROME
Sequence: MTEKFNGFSHDEILKITGVKEGGVGKRPASLEAAKPALRIQPGIRRMPDKIFRQADQLRKQQQQQPQQPIQKPDVAKKTKSGTATPTEKPPTPTPAAEDDVANGSLNLDRPLSDSLIEALYHGNATARDKKTPATYADAETTSTDDSSILKISGGDSQTTSSTDDGSILPSTQDTSPRERLNTDSPFKGISLKDFEQHRRMIEEQNKQKKQMLYQAIEQHTQKTAAESRKIEEIRHELSKLESDLAVDVALLRKQIDNACIHFANVEKQYVKIEAQFLRAKIELHNASEKKELLTEHLCTVIAHNEDRKAQKLTELMQKVGLSPTDDCQPIDLTQQSP
What is the function of this protein?
Required for centriole duplication likely through its interaction with Sas-6 (PubMed:29892014, PubMed:33704067).  During embryogenesis, maternally provided protein is required for centrosome duplication and nuclear division cycles of the syncytial embryos (PubMed:29892014).  In femoral chordotonal organs, required for sensory cilia structural integrity and functionality necessary for motor coordination (PubMed:29892014).  In male germline, has a role in cytokinesis which seems dependent on its localization to the Golgi (PubMed:29892014).
What are the official names of this protein?
RAB6-interacting golgin.
What is the protein family that this protein belongs to?
Belongs to the GORAB family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus, trans-Golgi network. Note=Co-localizes with the centriole in interphase and mitosis (PubMed:29892014). Mostly found in the Golgi, with a small amount detected in centrosomes (PubMed:29892014, PubMed:33704067). In spermatocytes, localizes to the trans-Golgi and inside the Golgi cisternae (PubMed:33704067).