PharMolix/UniProtQA huggingface dataset:
Protein: Y028_BRUSU
Sequence: MTYSKIQNILPGLGLSVAITAAAMVLEKIEEHYAGRAWLEALVIAILLGTAVRSLARPGPRFNKGINFSAKLLLEIAVALLGASISASAVIEAGSGLIFGIAAVVAVAITLSYGIGRLLKLPHRMAVLVACGNSICGNSAIAAMAPVIGAESEDVAASIAFTAILGVIVVLTLPLLVPLLGLSFTQYGILAGLTVYAVPQVLAATAPVSLLSVQLGTLVKLVRVLMLGPVILVFALISGNKNADVKPGFFQLVPWFIIGFLAMMALHSLHLIPEAILPAIQYASMLLTIISMAALGLGVDIRSVASAGGRVTLTAILSLIALCCISLGLIHMLGVA
What are the official names of this protein?
UPF0324 membrane protein BR0028/BS1330_I0028.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOLD2_RHIWR
Sequence: MAPSHAAHDSAATAHRIDGRAIARSLDERTAAAVRAIVARDGAPPGLAVVLVGNDPASEVYVGRKIEACRRVGILSFEHRLPAQTTQDALLTLIARLNADPTIHGILVQVPLPSHIDDGMVLSAIDPAKDVDGFHPVNVGRLSTGTGGLVPCTPLGVMMLLDSVIDDMKGMDAVVIGKSNIVGKPIAMLLLEREATVTVTHIETRGLPDIVRKADIIVAAAGAPRLVKGYWVKEGAVIIDVGITRLPGEGGKTRLVGDVAFDEVQHARAVTPVPGGVGPMTIACLLANTVKAAEMRG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 2.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: FDHE_ECO5E
Sequence: MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNLYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEASAQGKPPLDIHVLPRDKHWQKLLMALIAELKPEMSGPALAVIENLEKASTQELEDMASALFASDFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVCGSMPVSSMVQIGTTQGLRYLHCNLCETEWHVVRVKCSNCEQSGKLHYWSLDDEQAAIKAESCDDCGTYLKILYQEKEPKVEAVADDLASLVLDARMEQEGYARSSINPFLFPGEGE
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_SHEON
Sequence: MTSYTFTRELRLLTPAQFKSVFSNPIKASSAEITLLAIPNSEQHPRLGLTVAKRYVKRANQRNRIKRVIRDSFRLNQHNIPHLDIVVLVRNGVMEMENAELNKLIEKLWRKLSRRYNG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: PRA14_HUMAN
Sequence: MSIQAPPRLLELAGQSLLRDQALSISAMEELPRVLYLPLFMEAFRRRHFQTLTVMVQAWPFTCLPLGSLMKTLHLETLKALLEGLHMLLTQKDRPRRWKLQVLDLRDVDENFWARWPGAWALSCFPETMSKRQTAEDCPRMGEHQPLKVFIDICLKEIPQDECLRYLFQWVYQRRGLVHLCCSKLVNYLTPIKHLRKSLKIIYLNSIQQLEIRNMSWPRLIRKLRCYLKEMKNLRKLVFSRCHHSMSDNELEGRLVTKFSSVFLRLEHLQLLKIKLITFFSGHLEQLIRCLQNPLENLELTYGYLLEEDMKCLSQYPSLGYLKHLNLSYVLLFRISLEPLGALLEKIAASLETLILEGCQIHYSQLSAILPGLSHCSQLTTFYFGRNCMSMGALKDLLCHTSGLSKLSLETYPAPEESLNSLVRVDWEIFALLRAELMCTLREVRQPKRIFIGPTPCPSCGSSPSEELELHLCC
What are the official names of this protein?
PRAME family member 14.
What is the protein family that this protein belongs to?
Belongs to the PRAME family.
Protein: RUVC_RHIL3
Sequence: MQNTIRIVGIDPGLRRTGWGIIETSGNSLRFVASGTVTSDGDMDLASRLCQLHDGLAEIVHSYKPDEAAVEQTFVNKDAVATLKLGQARGIAMLVPARAGLPVSEYAPNAVKKAVIGVGHGEKQQIHMMLKILMPKVEFKGNDAADALAIAICHAHNRGSNRMRQALAG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: RK23_PINTH
Sequence: MDEVKYPVLTEKSIRLLERNQYTFNVDSQSNKTKIKNWIENFFDVKVIAMNSYRLPEKGGKRVSMIGHPIRCKRVIITLRTGDSIPLFSEQ
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: OTC_NOSS1
Sequence: MAALLGRDLLSLADLTPTELQELLQLATQLKSQQLKLRCNKVLGLLFSKASTRTRVSFTVAMYQLGGQVIDLNPNVTQVSRGEPVQDTARVLERYLDVLAIRTFEQQELATFAEYAKIPVINALTDLEHPCQILADLLTVQECFDSISGLTLTYVGDGNNVANSLMLGCALAGMNVRIATPSGYEPNPQVVAQAQAIADGKTEILLTNDPDLATKGASVLYTDVWASMGQEAEADDRFPIFQPYQISEQLLSLAEPNAIVLHCLPAHRGEEITEEVIEGSQSRVWQQAENRLHVQKALLASILGAE
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS2_CLOAB
Sequence: MLDLDLIRNDTEKVKKALLKKIDNVDFTELLKLDDERRKLIHEVEVLKNKKNEASKQISNIKSQGGKVDESFFKDIKEISNKISELETSLEPIKGKMDTFLEALPNIPDEDVLPGGKENNKVVHVYGEKPQFEFEPKDHVELSNIHDLIDYKRGTKLSGNGFWIYKGYGAILEWALLNYFIEEHIKDGYEFILPPHILNYECGRTAGQFPKFKDEVFKVGSNGEGEGMQFILPTAETALVNLHRDEILKEDELPKKYFAYTPCYRVEAGSYRASERGMIRGHQFNKIEMFQYTKPEDSDAALEELIGKAEKLVKGLGLHYRLSKLAAADCSASMAKTYDIEVWIPSMNEYKEVSSASNARDYQARRGKIRFRREETKKIEYVNTLNASGLATSRVLPAILEQMQDKDGSIVVPEVLRKWVGKDKL
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase 2, Seryl-tRNA synthetase 2, SerRS 2, Seryl-tRNA(Ser/Sec) synthetase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QCR7_ASHGO
Sequence: MPQSFSSIVRMGDYILKSPTLSKIAVPVAQQFVKLSGYRQLGLKFDDLIAEENDIVQTALRRLPEEESYARVFRIIQAHQLELTHHLLPKHKWTKPEEDKSYLLPYLLEAEAAAKEKLELDALELK
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
What are the official names of this protein?
Cytochrome b-c1 complex subunit 7, Complex III subunit 7, Complex III subunit VII, Ubiquinol-cytochrome c reductase complex 14 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the UQCRB/QCR7 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: SYA_CHLPN
Sequence: MLSNTIRSNFLKFYANRHHTILPSSPVFPHNDPSILFTNAGMNQFKDIFLNKEKVSYSRATTSQKCIRAGGKHNDLDNVGHTSRHLTFFEMLGNFSFGDYFKAEAIAFAWEVSLSVFNFNPEGIYATVHEKDDEAFALWEAYLPTDRIFRLTDKDNFWSMANTGPCGYCSELLFDRGPSFGNASSPLDDTDGERFLEYWNLVFMEFNRTSEGSLLALPNKHVDTGAGLERLVSLIAGTHTVFEADVLRELIAKTEQLSGKVYHPDDSGAAFRVIADHVRSLSFAIADGLLPGNTERGYVLRKILRRSVNYGRRLGFRNPFLAEIVPSLADAMGEAYPELKNSLSQIQKVLTLEEESFFKTLDRGGNLLQQVLKSSSSSSCISGEDAFKLKDTYGMPIDEISLLAKDYDYSVDMDTFHKLEQEAKERSRKNVVQSQGTSESIYNELHLTSEFIGYDHLSCDTFIEAIISKDHIVSSLQEKQEGAIVLKVSPFYAEKGGQVGDSGEIFCSEGTFIVTHTTSPKAGLIVHHGRISQGSLTVEAAVTAQVNRYRRKRIANNHTACHLLHKALEITLGDHIRQAGSYVDDTKIRLDFTHPQAISPEDLLCIETLVNESIRENEPVDIREALYSDVMNSSEIKQFFGDKYSDVVRVVSAGHSHELCGGTHAEATGDIGFFRITKEHAVAMGIRRIEAVTGEKAEATVHQQSEVLEEIATLLQVPRDQIVSRLTATLDERKQQDKRLNELENSLIQTKLDKLIHNCHQRQGITCLVHHLAEHENHRLQQYAQCLHQRIPEKLISLWTTEKNGKYIVLSRVSDDLITQGVHAQDLLKAVLTPCGGRWGGKDQSAQGSAPALPATEVLNETLWQWISTQLI
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXK_FRATF
Sequence: MLDKIWYRSKPNLLSRVLQPISLVFIDIANKRKIKQQLKQYKSKIPIIVVGNISVGGTGKTPVVRMLVQQYLAQDKKPAIISRGYGAKADNYPFEVTSGTLATQCGDEPAMLFDALQAQVPIVIAPERVQAVKYIEKNFPDTDIIMSDDGLQHYKLARDKEIVVVDAIRMFGNKLCLPAGPLREPIERLKEVDQIIVIGNCSDKDKELLKNYKNVTYAKVVATEFVNILTAKKVAKTEFNHQNAIAIAGIGNPTKFFKTLEESAINITAKKVFKDHHKFTQSDFEGIDSDITVVMTYKDAIKCKNFAKANWWYLDIALDINV
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: RGS13_MOUSE
Sequence: MSRHICWICKLCRDESKRLPSNLTLDEVLKWAQSLESLMATKYGPIVYTAYLKLEHSDENIKFWMACETYKKIASRRGRISRAKKLYNIYIQPQSPREINIDSTTREAIIKSIREPTQTCFEEAQKIVYMHMEMDSYPRFLKSEMYQQLLKTVQSQSS
What is the function of this protein?
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.  Binds to both G(i)-alpha and G(q)-alpha.
What are the official names of this protein?
Regulator of G-protein signaling 13, RGS13.
Protein: MMGT2_MOUSE
Sequence: MVAWLWKVLMGVGLFALTHAAFSAAQHRSHARLTEKKYEPLPADIVLQTLLAFALTCYGVVHTAGDFRDRDATSELKDMTFDTLRNRPSFYVFHRSGYRLFQRPDSTHSSNLSASSSDLPLKF
What is the function of this protein?
Mediates Mg(2+) transport.
What are the official names of this protein?
Membrane magnesium transporter 2.
What is the protein family that this protein belongs to?
Belongs to the membrane magnesium transporter (TC 1.A.67) family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: GLMU_THEP1
Sequence: MRALVLAAGKGTRMKSKIPKVLHPLSGKPMIEWVVETAGKVAQKVGVVLGFEAELVRKTLPEWVDVFVQEEQLGTAHAVMCAKDFIEPGDDVLILYGDVPLISENTLKRMIEEHRKGADVTILVADLEDPSGYGRVIQDGDKYRIIEDADLPEELKSVTTINTGFYVFSGDFLLRVLPEIKNENAKGEYYLTDAVNFAEKVRVVKTDDLLEITGVNTRKTLVWLEEQLRMRKIEELLENGVTILDPATTYIHYSVEIGMDTVIHPMTFIEGRTRVGENCEIGPMTRIVDCEIGNNVKITRSECFKSVIEDDVSVGPFARLREGTILKKSSKIGNFVEIKKSTIGEGTKAQHLSYIGDAFVGKNVNIGAGTITCNYDGKKKNPTFIEDGAFIGSNSSLVAPVRIGEGALIGAGSVITEDVPPYSLGLGRARQVVKEGWVLKKRKEE
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2306_MYCTU
Sequence: MTRVALLTTGRELSQAAPPARARTPLPVPTPRGERPDDGGHAPHRDRRVNQRRRQVGDRRAQRGVDEHPWRRPDERPNDHLPQRNSERPEGVRGQRIRDAGDEALTDHRPQSAPFDLCIEAMGAIDTQQRLGVIPACAPAEKAGRVTKVSSSGPNSTPLPAARIGPGTNNAPSAADTTTYARGAIGPVATTIALRTPSTWMTRATATR
What are the official names of this protein?
Uncharacterized protein Rv2306c.
Protein: PI4KB_CALJA
Sequence: MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQDVLEKVKLLHGGVAVSSRGAPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGASVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVYRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
What is the function of this protein?
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP).  May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity).  Involved in Golgi-to-plasma membrane trafficking (By similarity).
What are the official names of this protein?
Phosphatidylinositol 4-kinase beta, PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
What are the subcellular locations of this protein?
Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Golgi apparatus membrane. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3, GGA2 is also involved in the recruitment.
Protein: ATPD_PARPJ
Sequence: MAELATIARPYAEALFGVAEAGDIAAWSTLVQELAQVARLPEVLSIASSPKVSRAQVSELLLAAVKSPLKDNAQAKNLVQMLVDNHRLQLLPEIAVQFEELKNAREGAADVLIVSAFPLEGAQLNDLVASLERKFKRKLKPTVEIDPSLIGGVRVTVGDEVLDTSVRARLASMQTALTA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AGMR_PSEAE
Sequence: MYKILIADDHPLFREAIHNVIADGFPGSEVMETADLDSALGLTQEHDDLDLILLDLNMPGMHGLNGLMNLRNEAPTIPVVIVSAEQDKQVVLQAITYGAVGFITKSSPRAQMTEAIEQILNGNVYLPSDVIRTQKSSPRRSGHEEHGISPELLQALTRKQLLVLERMTKGESNKQIAYNLDIAETTVKAHVSAILRKLKVHNRVQAILSAGDIDFAAYLRR
What is the function of this protein?
Positive activator for glycerol metabolism.
What are the official names of this protein?
Glycerol metabolism activator, Protein AgmR.
Protein: PRVB3_MERCP
Sequence: AFAGVLADADIKAALAGCAAAESFNYKTFFKFFAIIDQDHSGFIEEEELKALSDAETK
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions (By similarity).
What are the official names of this protein?
Parvalbumin beta 3.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: ORF4B_BCHK5
Sequence: MDDSMDLDLDCVIAQPSSTIVMMPLSPISTRKRRRHPMNKRRYAKRRFTPVEPNDIIMCDKPTHCIRLVFDQSLRWVHFDGIKNILTDYDVIFNPDLHVTVALVCAGNGVTFSDLTPLTFILADMLLEFNGIFTLGQTLVIGAREYHWLPQELKTNVGKAIPQAKEWLVDHGYNVYHTGLPTHMSLAKLHSLDFVQQSYVGSKFFIKHSHTTEYAMPVCLQVIAIDGEKVDGRSKPLFQYPIHNHYRHYRACFPGR
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by inhibiting the interaction between host IKBKE and MAVS.  In turn, this inhibition prevents the production of host interferon beta.  Additionally, may also interfere with host antiviral response within the nucleus.
What are the official names of this protein?
Non-structural protein ORF4b, ORF4b.
What are the subcellular locations of this protein?
Host nucleus. Host nucleus, host nucleolus. Host cytoplasm. Note=Mainly localized in the host nucleus.
Protein: URE3_NITMU
Sequence: MDLTPREKDKLQIFTAGLLAERRKARGLRLNYPEAVALITCAILEGARDGNTVAELMSEGRKVLTRADVMEGVPEMIPDIQVEATFPDGTKLVTVHNPIV
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDT1_MYCTU
Sequence: MRRVVRYLSVVVAITLMLTAESVSIATAAVPPLQPIPGVASVSPANGAVVGVAHPVVVTFTTPVTDRRAVERSIRISTPHNTTGHFEWVASNVVRWVPHRYWPPHTRVSVGVQELTEGFETGDALIGVASISAHTFTVSRNGEVLRTMPASLGKPSRPTPIGSFHAMSKERTVVMDSRTIGIPLNSSDGYLLTAHYAVRVTWSGVYVHSAPWSVNSQGYANVSHGCINLSPDNAAWYFDAVTVGDPIEVVG
What is the function of this protein?
Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem.  Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.  Is thought to play a role in adaptation to the nonreplicative state of M. tuberculosis.
What are the official names of this protein?
L,D-transpeptidase 1, LDT 1, Ldt(Mt1).
What are the subcellular locations of this protein?
Periplasm.
Protein: QUEC_SHEPA
Sequence: MSKAVVVFSGGQDSTTCLIQALQHFDEVHGITFDYGQRHREEIEIAKTLASKLKLASHKVMDVTLLNELAISALTRDSIPVSNDLMDNGLPNTFVPGRNILFLTLAGIYAYQLGADVVITGVCETDFSGYPDCRNDFVKAMQAALEQGMDKKLTIQTPLMWLDKAETWALADKYQSLDLIRDETLTCYNGIKGDGCGTCPACLLRKRGLEEYLADKEAIQARLTAKC
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: SPC24_ASPFU
Sequence: MLLDEDPATLIHHTIGNFNIQPDKQAVTRINDSLSTLQQSRELRMRDAESALRKLSRNLHALTAQHEEAVSSHDSAKHAAQMVELDTKKFRIAKAATELEIESERLEGELEMLKERLAELEAQGLEGDEATRREREADDATILRLKIYRSLGIDIEADEAGNFSKAVIRNSRKGDVHVVNMDPKFSRFFYANYFWSTMQG
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
What are the official names of this protein?
Probable kinetochore protein spc24.
What is the protein family that this protein belongs to?
Belongs to the SPC24 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Associated with kinetochores.
Protein: Y1778_OCEIH
Sequence: MLSPVTAKDKKSFIQWFLNHYRLKKRESVWILNYLVNHSDLLANVHFVRDVKYCPRGIMMTSHCSDEVPFRFYKNHLVTTDAEKSFHDIRLNQNESLYVQLNFRKSNQHSYYASVLEENPFIPEDYYLTTDDKETANGLLDYLLFEQKRNKIIFDIDKALDNGDKELFQKLSEKLEKLSSNRQK
What are the official names of this protein?
UPF0302 protein OB1778.
What is the protein family that this protein belongs to?
Belongs to the UPF0302 family.
Protein: PPME1_CANAL
Sequence: MSELHKAFLRRIKEQETALGLSGLVDEDDIPEPAVMPPTGNSSSTANTEDETILRDYKQFKETNFIQEFYENELGHKFKTYYKPSKKPGSILFCHHGAGSSSMTFGNLVNHIEDESVGIFLFDTRGHGESVATSDFSLDTLVQDVSFVLEQFSSKHQQTSIFLLGHSLGGAVLAKYSTLYPSDILKGLILLDIVEEAAVQSLNAMPSFIARRPLSFPSLSKAISWHMNFLLFNEKSARLSVPDLFTDKLTWITDLNATQPYWQTWFSGLSENFLGFKGPKLLMLSTHESLDKQLMIGQMQGKYQLVVFKNNEKSGHFVHEDLPNHVAVCLTDYIKRAVAPEIFMKEDLGVVPKWGGKINK
What is the function of this protein?
Demethylates proteins that have been reversibly carboxymethylated.  Demethylates the phosphatase PP2A catalytic subunit (By similarity).  Involved in the regulation of filamentous growth.
What are the official names of this protein?
Protein phosphatase methylesterase 1, PME-1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: FMT_ALKEH
Sequence: MSGAPRLVFAGTPDFAVPSLQALLEAGHRPVAVYTQPDRRAGRGRRPRPSPVKQQAEAQGLPVRQPESLRDPRAQAELAELAPDLMVVIAYGLILPQAVLQIPALGCVNLHASLLPRWRGAAPIQRAILAGDDETGVCLMRMEAGLDTGPVLARARCPIGPRETGGSLHDRLAALAGTLLHDRLDDLLADRLPAQPQPEAGVCYADKLRKDEAWLDWRRDARQLDRQVRAFNPWPVAQTLCQGQVLRVWEAEPVAAPAGDAAPGTVVRADGDGIVVVAGEGALRLQTLQAAGGRPLGVREFLNGRALQAGERLG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: WRNXO_DROME
Sequence: MEKYLTKMPIKSKANEVPKEEAGVKKETPKVARKATKKDTPKELKDKENAGDDNTPKQTKGRPGRPAAKRKNLDTPDVTEKLAMEEENPPKRRSSRLTRSTRSMAEDGSPSPEKEKPEKLPFIKYKGAIKYFTESQDIAASADDVLQWVEKQKDEVVPMAFDMEWPFSFQTGPGKSAVIQICVDEKCCYIYQLTNVKKLPAALVALINHPKVRLHGVNIKNDFRKLARDFPEVTAEPLIEKCVDLGLWCNEVCETGGRWSLERLTNFIAKKAMDKSKKVRMSKWHVIPLDENQLMYAAIDVYIGQVIYRELERREKVKIKNEEEFKEKNGDAAFKAMKALGETFLTKINEVTL
What is the function of this protein?
Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction (PubMed:18346216, PubMed:18056975, PubMed:18956248).  Essential for the formation of DNA replication focal centers (PubMed:18346216, PubMed:18956248).  Has an important role in maintaining genome stability (PubMed:18346216, PubMed:18956248).
What are the official names of this protein?
3'-5' exonuclease, Werner Syndrome-like exonuclease, DmWRNexo.
What is the protein family that this protein belongs to?
Belongs to the WRNexo family.
What are the subcellular locations of this protein?
Nucleus.