PharMolix/UniProtQA huggingface dataset:
Protein: DTD_PSEPF
Sequence: MKGLLQRVKGARVEVAGEVVGSVDQGLLVLVAVEPDDTPASADKLLHKLLNYRVFSDAEGKMNLSLADVGGGLLLVSQFTLAADTKSGLRPSFSTAAPPALGEKLFDYLLSRAKQMHGTVASGRFGADMQVHLVNDGPVTFLLQT
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FB179_ARATH
Sequence: MEWRSLPVELQEEILSRVPAKYLARLRSTSKQWNALSKTGSFAKKHSANATKEPLIIMLKDSRVYLASVNLHGVHNNVAQSFELGSRLYLKDPHISNVFHCDGLLLLCSIKENTLEVWNPCSGEAKLIKPRHSYYKESDFYALGYDNKSSCKKYKVLRVISQVHVQGDFKIEYEIYDFTNDSWRVHGATTELSIRQKHPVSVKGSTYWVVRNRYFPYKYFLSFDFSTERFQSLSLPQPFPYLVTDLSVVREEQLCLFGYYNWSTTSEDLNVWVTTSLGSVVSWSKFLTIQIIKPRVDMFDYGMSFLVDEQNKSLVCWISQKVLHIVGEIYHIQDLDDHGRDSALRSSCSVLMNYVPSLAQIQ
What are the official names of this protein?
Putative F-box protein At3g23260.
Protein: IF4E3_CAEEL
Sequence: MSTSVAENKALSASGDVNASDASVPPELLTRHPLQNRWALWYLKADRNKEWEDCLKMVSLFDTVEDFWSLYNHIQSAGGLNWGSDYYLFKEGIKPMWEDVNNVQGGRWLVVVDKQKLQRRTQLLDHYWLELLMAIVGEQFDEYGDYICGAVVNVRQKGDKVSLWTRDATRDDVNLRIGQVLKQKLSIPDTEILRYEVHKDSSARTSSTVKPRICLPAKDPAPVKEKGPAATTSPSNPGTEATGTSPATPTP
What is the function of this protein?
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.  All 5 eIF4E proteins bind monomethyl cap structures.  Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing.  Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps.  Ife-3 is essential for viability.  Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475).  Within the pid-1 variant of the PETISCO complex binds to capped 21U-RNA precursor molecules, possibly playing a role in the processing of the 5' end of the molecules to promote binding of other complex components such as pid-3 (PubMed:31147388).  However, it is not essential for the biogenesis of 21U-RNAs by itself (PubMed:31147388).  Within the tost-1 variant of the PETISCO complex binds to splice leader SL1 RNA fragments to possibly play a role in their processing (PubMed:31147388).
What are the official names of this protein?
Eukaryotic translation initiation factor 4E-3, eIF-4E-3, eIF4E-3, eIF-4F 25 kDa subunit, mRNA cap-binding protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
What are the subcellular locations of this protein?
Cytoplasmic granule. Cytoplasm, perinuclear region. Note=Localizes to cytoplasmic granules in early embryos (PubMed:31147388). Localizes to puncta in the perinuclear region in the germline syncytium (PubMed:31216475, PubMed:31147388).
Protein: ORYE_ASPOR
Sequence: MTVTQEASPKRESLHIIDDRTGSYYSIPIVNNAINASDFKKVTAPEDKAYPANQTENGLRVYDPGYSNTAVSHSKITYIDGLKGTIQYRGYSINDIVGRKTFIDTAHLLIWGHWPSTAEAETLQQRLDQVPVPQDFVFNVIKSFPRDGSLMGMVIAGLSALQSSDMNAIPAHVGKTIYLNNPELADQQIIRVMANMSMLTAAAYCHHIGRDFTPPRAGLSYIENFLLMTGHVEAATGLPNPRYVNAIERLWVLIADHEMTCSTAALLQTASALPDVISCMVSAISALYGPLHGGAIEVAYKNIESIGSISNVPAKIARVKAGKERLYGYGHRVYRVTDPRFVFIREILNELSEEVEKDPLLKVAFEVDRVASEDEYFTSRNLRPNADLFAAFVYKALGFPPEFILPLSILSRTQGFMAHWREAMGNPPRIWRPGQIYTGDLNKSMDE
What is the function of this protein?
Citrate synthase-like protein; part of the gene cluster that mediates the biosynthesis of oryzines, natural products with an unusual maleidride backbone (PubMed:30104550).  The two subunits of the fungal fatty acid synthase oryfasA and oryfasB probably form octenoic acid (Probable).  This fatty acid is most likely activated by the acyl-CoA ligase oryP to give octenyl-CoA before the citrate synthase-like protein oryE catalyzes condensation with oxaloacetate to form tricarboxylic acid (Probable).  The next steps of the pathways are conjectural, but a favorite possible route has been proposed, beginning with decarboxylation and concomitant dehydration by the decarboxylase oryM, followed by tautomerization, which may lead to the production of a diene intermediate (Probable).  Reduction of this diene intermediate could give the known metabolite piliformic acid (Probable).  On the pathway to oryzine B and oryzine A, however, hydroxylation of the diene by the alpha-ketoglutarate-dependent dioxygenase oryG and lactonisation by the lactonohydrolases oryH or oryL could give oryzine B directly (Probable).  Finally, enoyl reduction by the dehydrogenase oryD would then convert oryzine B into oryzine A (Probable).
What are the official names of this protein?
Citrate synthase-like protein oryE, Oryzines biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
Protein: RL14_BACC3
Sequence: MIQQESRLKVADNSGARELLTIKVLGGSGRKYANIGDIIVATVKQATPGGVVKKGDVVKAVVVRTKSGARRPDGSYIKFDENAAVIIKDDKSPRGTRIFGPVARELRDSNFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ICK25_TRILK
Sequence: MKTIIVFLSLLVLATKFGDAKEGVNQEQKKEVTQNEFRVEYLNEMAAMSLLQQLEAIESALFEKEAGRNSRQKRCNGKNVPCGANHSPCCSGLSCEETFGYGWLYKSPYCVIPSNG
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U16-barytoxin-Tl1a, U16-BATX-Tl1a, Toxin ICK-25.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 14 (magi-1) family. 06 (ICK-Trit) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPF_OENPA
Sequence: MKNVTDSFVSLVHWPSAGSFGFNTDILATNPINLSVVLGVLIFFGKGVLSDLLDNRKQRILNTIRNSEELREGAIEQLEKARARLQDVQIEAEGYRAYGYFGIDEQRHESINSTYKTLEQLENNKNESIHFEQQRAINQVRQQIFQQALQGALGTLNSCLNNELHLRTISANIGLFGSMKELTD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PRS58_MOUSE
Sequence: MKLAFLCILSTLLRTFAYNPDHIAGTTPPYLVYLKSDYLPCTGVLIHPLWVITAAHCNLPNLQVILGITNPADPMERDVEVSDYEKIFHHPNFLVSSISHDLLLIKLKRRIKHSNYAKAVKLPQHIVSVNAMCSVSTWAYNLCDVTKDPDSLQTVNVTVISKAECRNAYKAFDITENMICVGIVPGRRLPCKEVTAAPAVCNGVLYGILSYADGCVLRADVGIYASIFHYLPWIEDTMKNN
What are the official names of this protein?
Putative inactive serine protease 58, Trypsin-X3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GBRG2_PONAB
Sequence: MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity).  The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).  The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).  Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cytoplasmic vesicle membrane.
Protein: PROQ_SHISS
Sequence: MENQPKLNSSKEVIAFLAERFPHCFSAEGEARPLKIGIFQDLVDRVAGEMNLSKTQLRSALRLYTSSWRYLYGVKPGATRVDLDGNPCGELDEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAAAAGEKEDAPRRERKPRPTTPRRKEGAERKPRAQKPVEKAPKTVKAPREEQHTPVSDISALTVGQALKVKAGQNAMDATVLEITKDGVRVQLNSGMSLIVRAEHLVF
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.  May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_PVX
Sequence: MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP
What is the function of this protein?
Required for genome encapsidation.  Forms ribonucleoprotein complexes along with TGB1 helicase and viral RNA.
What are the official names of this protein?
Coat protein, Capsid protein, CP.
What is the protein family that this protein belongs to?
Belongs to the potexvirus capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: HC2D_CHLTR
Sequence: MLGVQKKCSTRKTAARKTVVRKPAAKKTAAKKAPVRKVAAKKTVARKTVAKKTVAARKPVAKKATAKKAPVRKVAAKKTVARKTVAKKTVAARKPVAKKATAKKAPVRKAVAKKTVARKTVAKKTVAARKPVAKRVASTKKSSIAVKAGVCMKKHKHTAACGRVAASGVKVCASAAKRKTNPNRSRTAHSWRQQLMKLVAR
What is the function of this protein?
Might have a role in establishing the nucleoid structure of elementary bodies.
What are the official names of this protein?
Histone-like protein HC2.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family. HCT subfamily.
Protein: SPCS2_CAEEL
Sequence: MTDEPVKVVNKWDGPTVKNALDEVVKKILNDKVGWTESHNLMNLRLLISFIGVAFSAFACGYDYYEPFPKSKIVLAVCSVSYFICMGILQMYQWYVEKDCIYEATEVDGKQSRKWAWSSEIKAHDDKYTLSAEFKKEGRSGQGKITKSIGAYIDNDGEIIVPLVKKEVDDLYNRLIRSEQ
What is the function of this protein?
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
What are the official names of this protein?
Signal peptidase complex subunit 2, Microsomal signal peptidase 25 kDa subunit, SPase 25 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the SPCS2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: KUP_ACIET
Sequence: MQTSKSSLAALTLGAIGVVYGDIGTSVLYAVKEVFGSGHVPFTHANVYGVLSVLFWTLTVIVSLKYVVLVLRADNHGEGGLIAMLALASQAVKDRPRLRGWLLGLGIFGTSLFYGDGVITPAISVLSAIEGLEVVSPHFGKAVIPLTLVVLFGLFAVQKRGTAGVGRYFGPVTLVWFFTIAALGVPHIVGHPEILGALSPHHALGFILGNPGISFIILGAVVLCVTGAEALYADLGHFGKRPIRLAWFSVAMPALTINYFGQGALLLAEPSAVKNPFYMMAPDWALVPLVVLATMATVIASQALITGAFSVTKQVIQLGYLPRLNIQHTSVRETGQIYLPFVNWSLFVAIVLAVVMFRNSSNLAAAYGIAVTLDMLITTVLTFFVIRYGWGYPLALCVATTGFFFVVDLAFFSSNLLKLLQGGWFPLMIGGLVFTLMMTWKRGRELLNDKLREDSIGLQDFLASVQANPPMRVDGTAVFLSAEAGVVPNALLHNLKHNKVLHRQNLFVTVRYHETPWIGLDQRLQVAPLGGDCWQVTVNYGFKNELDLPSALRLMHGRGCELETMSTSYFLSRDVVVPTIGSGMAPWREKLFAQMHHNASGVAAFLHLPSNAVVELGSKVEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOB_BORPD
Sequence: MPYSYTEKKRIRKSFAKREDVQDVPFLLATQLQSYLTFLQADTPPSDRASEGLQAAFSSIFPIVSHNGMARLEFVSYVLGEPVFDVKECQQRGLTYASPLRAKVRLVLLDREVSKPTIKEVKEQEVYMGEIPLMTGTGSFVINGTERVIVSQLHRSPGVFFEHDRGKTHSSGKLLFSARVIPYRGSWLDFEFDPKDVLFFRVDRRRKMPVTILLKAIGMTPESILAHFFDFDNFELKSEGGMIEFVPERWKGEMARFDITGRDGNVIVEKDKRINAKHLRDMANANIQRVSVPEEFLYGRVLAKNIVDPDTGEVVAHANDEITESVLSALRAANVRDIQTLYTNDLDRGPYISQTLRTDETADQMAARVAIYRMMRPGEPPTEDAVEALFQRLFYSEETYDLSRVGRMKVNSRLGRGEDITGPMTLTNEDILETIKVLVELRNGRGQIDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAETENLMPHDLINSKPISAAIKEFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSMALYARLNEYGFLETPYRKIIDGKVSDQIDYLSAIEESNYVIAQANAALDDEGRFVDDLVACREAGETMLTAPANVHYMDVAPSQIVSVAASLIPFLEHDDANRALMGANMQRQAVPCLRPEKPVVGTGVERTVAVDSGTTVQALRGGVVDHVDAERVVIRVNDDENVAGEVGVDIYNLIKYTRSNQNTNINQRPIVKRGDKVAKGDVLADGASTDLGELALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEELTVVARDTKLGPEEITRDISNLAETQLNRLDDSGIVYIGAEVTADDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMVGTVIDVQVFTREGIVRDKRAQSIIDDELRRYRQDLNDQLRIVENDQFDRIEKLLIGKTVNGGPRKLAKGATITKAYLADLDRWQWFDIRLADEPHAVVLEQAKESLEQKRHQFDLAFEEKRKKLTQGDELPPGVLKMIKVYLAVKRRLQPGDKMAGRHGNKGVVSRITPVEDMPHMADGTPADIVLNPLGVPSRMNVGQVLEVHLGWAAKGVGHRIADMLRDERTAQVKNVRAYLDKVYNTTGTGEQIDTLTDDEVMELAQNLKNGVPFATPVFDGATEEEIGKMLELAYPDEVAKRMQLTDSRTQAWLFDGRTGEKFERPVTVGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDITGRTKVYENIVKGDHVIDAGMPESFNVLVKEIRSLALDMDLERN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RLMN_PSEA7
Sequence: MTTATGKVNLLGLTQPQLEQFFESIGEKRFRAGQVMKWIHHFGVDDFDAMTNVGKALREKLKAFAEIRGPEIVSQDISADGTRKWVVRVASGSCVETVYIPQGGRGTLCVSSQAGCALDCSFCSTGKQGFNSDLSAAEVIGQVWIANKSFGTVPAKIDRAITNVVMMGMGEPLLNFDNVVAAMNIMMDDLGYGISKRKVTLSTSGVVPMIDKLGEVIDVSLALSLHAPNDELRNRLVPINKKYPLTMLLDACRRYISRLGEKRVLTVEYTLLKDVNDQPEHAEQMIALLKDTPCKINLIPFNPFPHSGYERPSNNAIRRFQDLLHKGGFNVTVRTTRGDDIDAACGQLVGQVMDRTRRSERYIAVRQLAESESAANRN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_SYNWW
Sequence: MELKIKKAELEGIYVDINQLPVGNIPEIALAGRSNVGKSSLINKICNRKNLAKSSSTPGKTRTINYYLINDQWFMVDLPGYGYARVSREEKARWKKMVEAYLSQREQLRGVIQLLDIRHEPGENDILMKDWLLHLQIPVLVVATKADKLSRGARMKHIAIIRKTLDLPEMPLVFSAQSGDGVEELKAALAELL
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: HUTU_YERPA
Sequence: MTTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGIGRAARNWECYDKIVESLINLNDDETLLIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHFGGSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVAVSIALCGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALVINAAKISMAEHVEAMLAFHNMGIPTFDYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFCRGIGPFRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLDMARERIRFQGLPARICWVGLGQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHADAGYDIAVNCAQEQGLNLPMVAATQGKKS
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCO2_RAT
Sequence: MELLKALLLLSGVLGALAEFCVIPKMDGQLVEKLGQRLLPWMDRLSSEQLNPSIYVGLRLSSMQAGTKENLYLHNLKLHYQQCLLRSTSSDDNSGCQTKISGGSLALYLLALRANCELLGSRKGDRMVSQLKWFLEDEKKAIGHHHEGHPHTSYYQYGLSILALCVHRKRVHDSVVGKLLYAVEHDYFTYQGHLSVDTEAMAGLAFTCLERFNFNSDLRPRITTAIETVREKILKAQAPEGYFGNIYSTPLALQMLMTSPGVGLGPACLKARKSLLLSLQDGAFQNPMMISQLLPVLNHKTYLNLISPDCQAPRVMLVPATEDPVHLSEVSVTLKVSSVLPPYERTVSVFAGASLEDVLNRARDLGEFTYGTQASLSGPYLTSVLGKEAGDREYWQLLRVPDTPLLQGIADYKPKNGETIELRLVKM
What is the function of this protein?
Primary vitamin B12-binding and transport protein.  Delivers cobalamin to cells.
What are the official names of this protein?
Transcobalamin-2, TC-2, Transcobalamin II, TC II, TCII.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic cobalamin transport proteins family.
What are the subcellular locations of this protein?
Secreted.
Protein: CP2E1_RAT
Sequence: MAVLGITIALLVWVATLLVISIWKQIYNSWNLPPGPFPLPILGNIFQLDLKDIPKSFTKLAKRFGPVFTLHLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNEARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKKCLRLMSLFNENFYLLSTPWIQLYNNFADYLRYLPGSHRKIMKNVSEIKQYTLEKAKEHLQSLDINCARDVTDCLLIEMEKEKHSQEPMYTMENVSVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQFKLCVIPRS
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids.  May be involved in the oxidative metabolism of xenobiotics.
What are the official names of this protein?
Cytochrome P450 2E1, 4-nitrophenol 2-hydroxylase, CYPIIE1, Cytochrome P450-J, Cytochrome P450RLM6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Note=Post- translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein.
Protein: MYF6_HUMAN
Sequence: MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPPEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPFSYRPKQENLEGADFLRTCSSQWPSVSDHSRGLVITAKEGGASIDSSASSSLRCLSSIVDSISSEERKLPCVEEVVEK
What is the function of this protein?
Involved in muscle differentiation (myogenic factor).  Induces fibroblasts to differentiate into myoblasts.  Probable sequence specific DNA-binding protein.
What are the official names of this protein?
Myogenic factor 6, Myf-6, Class C basic helix-loop-helix protein 4, bHLHc4, Muscle-specific regulatory factor 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL10_HELPH
Sequence: MQKQHQRQHKVELVANLKSQFADAKALLICDYKGLSVRKLEALRNKARNQGIKVQVIKNTLAHIAMKETGYSDLDLKETNVFLWGDDQIALSKLVFDFQKEHKDHFVLKAGLFDKESVSVAHVEAVSKLPSKEELMGMLLSVWTAPARYFVTGLDNLRKAKEEN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: GRND_DROME
Sequence: MSVRKLSALSLSIGGVPLIPSVSLVAAANGESRDCHGTICHPVNEFCYVATERCHPCIEVCNNQTHNYDAFLCAKECSAYKTFEPLKAEMLDIQNTQQLILLLLTILLVLIALRCAFQFLRWLIGNRCFQKLMRRLQSKAYPHPATANGKDLNATTIQNLNAINHPGSDLERAQSQIYSVAGAAEGSVVTMTTPVSTRYPAENSTTPTTVMTEIGYGYDNQAMVVTPVSEKPSAATIPVAF
What is the function of this protein?
Acts as a receptor for egr.  Plays a role in activation of JNK signaling and is required for egr-induced apoptosis.  May also play an egr-independent role in cell proliferation.
What are the official names of this protein?
Protein grindelwald.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein.
Protein: ETC1_CAEEL
Sequence: MIKSLNERDNFLNRLREMEHKREKDEKQEKAARKVQKFWRGHRVQHNQRLLFRAEFDAVSDRQRGLEETIKMAQLLVNFYETNKDEERLVMTLSELVKLKTSDKEFEKRIRETQRLLLARCCIKFLKNATENTIFFHIFRYLEDYVTCHSKLFEASSKLGLFNAEFHLLEALIGKPTGKTVERASLNPRILQLLTRIFETFVNPSRSTSVSVNVANRLLKTICVNITDLNFSNYILYYIKDHIKPTSPNFTNLFEAMKSVDILNNWKVRPEIAETASLRLQSIFVSQIVHVSNTQSEDVKQYFNSLAVFLEHHSKIMRSLNVKEDLSEFGRLRTSVNNHLKQYCEEMLISNEFRRAACIYANLPGVQVETIISLRKYFSQFLDLLAASNTFVEALYAFIARLCPNGEFDPIDAKSPKVNALELFCNCLNKRVSSVADSDFVPTDIFVDFDHTVEFLRDVSIKLIHLMFPTMARGDLYSGNLKEKMYKAETDWKDVTESVFSILGAIYQKDIRLKYFPEEFWTNHGREVLSGIGEHRRMPRRRMPNGRLQIERTMDTEFVERLAAIYEMDSDSENDDEDEDNNLPAVLRRAICVMKHIPFIVPFMDRVKLFTRLLNQDKEKHYTSTFGMGFNGPSVTVRRDQVYMDAFETFAPKMQGDKVNDLKSMVRVKMVNWAGMNESGIDGGGIFREFLSELLKTAFNVERGFFTFTESKLLYPNPTAPFLLGVDCLAHFQFIGRMIGKLIYERQLQEVRFAEFFIAQIFETDKNKDVDLQHMKSFDPIIFKHLKALQKMNNRELDELQLDFSVVTSDMGLVRNVNLKPNGSKFRVTVENVHEYVRLYVNYHLKQRIASMVDAVRKGISEIISIEWMRMFAPHELQIMIAGYEEVFTAKELRKFCELRFAAGTQDINYEEMFWDVIDKLSNDDKKALLKFVTGCSRAPVDGFKSIQPRMGVLVIPSSDDELPTSATCMNMLRIPKYSNRTKLEEKLRYAINSGAGFELA
What is the function of this protein?
E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes, such as ubc-18, in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  Ubiquitinates ify-1 and cyb-1 targeting them for degradation in post-meiotic embryos.
What are the official names of this protein?
E3 ubiquitin-protein ligase etc-1, HECT-type E3 ubiquitin transferase.