PharMolix/UniProtQA huggingface dataset:
Protein: KATG_ACICJ
Sequence: MSTEAKCPVTGGATRSSSAGIQSNADWWPNQINLGMLHQHSALSNPMDPDFDYAAEFKTLDLDAVIADLKALMTDSQDWWPADFGHYGPLFVRMAWHAAGTYRIGDGRGGAGAGQQRFAPLNSWPDNANLDKARRLLWPVKQKYGRKISWADLMVLAGNVALESMGFKTFGFGAGRVDTWEPDQGIYWGPETTWLDDKRYSGDRDLENPLAAVQMGLIYVNPEGPNGKPDPVAAARDIRETFARMAMNDEETVALIAGGHTFGKTHGAGDAALVGPEPEAAPIEQQGLGWISSYGTGKGSDAITGGPEVTWTQTPTQWSNFYFDNLFNYEWELTKSPAGAWQWVAKDAGDVIPDAFDAAKKHRPTMLTTDLSMRMDPAYEKISRRFHQNPDEFADAFARAWFKLTHRDMGPVSRYLGKLVPAEHLIWQDPVPAVDHKLIDAADIAALKAKLLATGIAPTRLALTAWASAATFRGSDKRGGANGARIRLAPQKDWAANEPAELAKVLAALEKVQAEFNAAATGGKKVSLADLIVLGGCAAIEAAAKAAGHDVTVPFTPGRTDATEAQTDVASFAVLEPKADGFRNYLGKGDPRAPEEQLIDRAQLMTLTAPEMTALIGGMRALGANVGGAKHGVFTTRPGALTNDFFVNLLDMNMSWHPAAEPGVYELRDRKSGAVKWTATRVDLVFGSNSQLRALAEVYGTQDGEAAFVKDFVAAWTKVMELDRFDLA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: NORW_ALIFM
Sequence: MNLPIVIIGSGFASYQLIKTIRRTNSDCPIHVFTNDSGDDYNKPDLSHVFSKQQSPEEVVTLSGGDFAEQYNVILHRHTLVESINPEQQTITANGEQYTYDKLVLATGSHTFVPPFHGDGCEDILTLNSLKEFSAIQQKILDAKNILVIGGGLIGTELAMDLANAGKMVTLVEPNSHLLANMMPDFISLPLENACKEKGVTVNLSDCVQAVNKQEQGYRVTTSNCHSYYVDCVISAAGLKPNTQLATEANLMVNRGIVVDSNLQTSANNIYALGDCAEIEGKVMAYLQPILLSANALAKTLLGTDTALALPNMMVKVKTPNYPVQLAGNTSTDIERWSVDIDTQGVCAKAYDVNNQLTGFVVTNERVKNAFTLFRELNTTN
What is the function of this protein?
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase.  Reduces the rubredoxin moiety of NO reductase.
What are the official names of this protein?
Nitric oxide reductase FlRd-NAD(+) reductase, Flavorubredoxin reductase, FlRd-reductase, FlavoRb reductase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_ECOL6
Sequence: MPVLHNRISNDALKAKMLAESEPRTTISFYKYFHIADPKVTRDALYQLFTALNVFGRVYLAHEGINAQISVPASNVETFRAQLYAFDPALEGLRLNIALDDDGKSFWVLRMKVRDRIVADGIDDPHFDASNVGEYLQAAEVNAMLDDPDALFIDMRNHYEYEVGHFENALEIPADTFREQLPKAVEMMQAHKDKKIVMYCTGGIRCEKASAWMKHNGFNKVWHIEGGIIEYARKARDQGLPVRFIGKNFVFDERMGERISDEIIAHCHQCGAPCDSHTNCKNDGCHLLFIQCPVCAEKYKGCCSEICCEESALPPDEQRRRRAGRENGNKIFNKSRGRLNTTLGIPDPTE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis.  May be part of an alternate pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs under aerobic conditions.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: DEF_SALTI
Sequence: MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRNGNPFELEADGLLAICIQHEMDHLVGKLFIDYLSPLKQQRIRQKVEKLDRLNARA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: ZNF28_HUMAN
Sequence: MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKTFFSTGQGNTEAFHTGTLQRQASHHIGDFCFQKIEKDIHGFQFQWKEDETNDHAAPMTEIKELTGSTGQHDQRHAGNKHIKDQLGLSFHSHLPELHIFQPEGKIGNQVEKSINNASSVSTSQRICCRPKTHISNKYGNNSLHSSLLTQKRNVHMREKSFQCIESGKSFNCSSLLKKHQITHLEEKQCKCDVYGKVFNQKRYLACHRRSHIDEKPYKCNECGKIFGHNTSLFLHKALHTADKPYECEECDKVFSRKSHLETHKIIYTGGKPYKCKVCDKAFTCNSYLAKHTIIHTGEKPYKCNECGKVFNRLSTLARHRRLHTGEKPYECEECEKVFSRKSHLERHKRIHTGEKPYKCKVCDKAFAYNSYLAKHSIIHTGEKPYKCNECGKVFNQQSTLARHHRLHTAEKPYKCEECDKVFRCKSHLERHRRIHTGEKPYKCKVCDKAFRSDSCLTEHQRVHTGEKPYMCNECGKVFSTKANLACHHKLHTAEKPYKCEECEKVFSRKSHMERHRRIHTGEKPYKCKVCDKAFRRDSHLAQHQRVHTGEKPYKCNECGKTFRQTSSLIIHRRLHTGEKPYKCNECGKTFSQMSSLVYHHRLHSGEKPYKCNECGKVFNQQAHLAQHQRVHTGEKPYKCNECGKTFSQMSNLVYHHRLHSGEKP
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 28, Zinc finger protein KOX24.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMA_STRAW
Sequence: MSSPAPDALLGPADIRELAAALGVRPTKQRGQNFVIDANTVRRIVRTAGVRPDDVVVEVGPGLGSLTLALLEAADRVIAVEIDDVLAGALPATIAARMPERAERFALVHSDAMHVRELPGPPPTALVANLPYNVAVPVLLHMLDTFPSIERTLVMVQAEVADRLAADPGSRVYGVPSVKANWHAEVKRAGSIGRNVFWPAPNVDSGLVSLVRRTEPIKTTASKTEVFAVVDAAFAQRRKTLRAALAGWAGSAAAAEAALVAAGVSPQARGESLTVEEFARIAENRGADHADDANN
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_PARD8
Sequence: MIVVPLKEGENIEKALKKFKRKFEKTGVVKELRGRQAFEKPSVTKRKQTMRAIYVQHLQQVEE
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: CAH1_PANTR
Sequence: MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHIAHWNSAKYSNLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
What is the function of this protein?
Catalyzes the reversible hydration of carbon dioxide.
What are the official names of this protein?
Carbonic anhydrase 1, Carbonate dehydratase I, Carbonic anhydrase I, CA-I.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRXB_MYCPU
Sequence: MSQNKIYDVAIIGAGPGALTAAIYTSRGNLDTVFIDNAAPGGKLIYASKIENWPGDTIVKGTDLAIRFFEHAQAFGAKYEYGKVVDLINIKDDLKELVLEDGKKIQAKSVIIASGMVSRKPREILNYDEFENRGVSYCVICDGPMYGHNPAIIIGGGNSAVEEGTFLSSIASKVYVIVRDSDFIAEKALVNDLKSRKNIEVLFNASVKELHGKDALEYAIVNHNGKEVKLEVASLFPYIGFLPSAEYAKNAGVLEPNGFIKTDEFMETKVPGIYAIGDIRIKDIRQILTATSDGTIAGKILTNRIKK
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3284_MYCTO
Sequence: MTAPASLPAPLAEVVSDFAEVQGQDKLRLLLEFANELPALPSHLAESAMEPVPECQSPLFLHVDASDPNRVRLHFSAPAEAPTTRGFASILAAGLDEQPAADILAVPEDFYTELGLAALISPLRLRGMSAMLARIKRRLREAD
What are the official names of this protein?
Uncharacterized SufE-like protein MT3383.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
Protein: RIMM_LACGA
Sequence: MTEYFEVGKILSPHGLKGEVKVNATTDFPEERLANGSRLFIKNSDQYQELIVDGARRHKQFYLVKFEEIDGIDQAEKVCGKELYVAETDQQELPEGSYYFKDILNCPVYDAETGEKLGVLANIETPGANDIWEIKPEHGKSFWIPNIESVVNKVDLANKRIEVTLLEGLRDEN
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFH_RAT
Sequence: MMSFGSADALLGAPFAPLHGGGSLHYALSRKAGAGGTRSAAGSSSGFHSWARTSVSSVSASPSRFRGAASSTDSLDTLSNGPEGCVAAVAARSEKEQLQALNDRFAGYIDKVRQLEAHNRTLEGEAAALRQQKGRAAMGELYEREVREMRGAVLRLGAARGHVRLEQEHLLEDIAHVRQRLDEEARQREEAEAAARALARFAQEAEAARVELQKKAQALQEECGYLRRHHQEEVGELLGQIQGCGAAQAQAQAEARDALKCDVTSALREIRAQLEGHTVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKESLERQRSELEDRHQVDMASYQDAIQQLDNELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPSPFSLTEGLPKIPSMSTHIKVKSEEKIKVVEKSEKETVIVEEQTEEIQVTEEVTEEEDKEAQGEEEEEAEEGGEEAATTSPPAEEAASPEKETKSPVKEEAKSPAEAKSPAEAKSPAEAKSPAEVKSPAEVKSPAEAKSPAEAKSPAEVKSPAEVKSPAEAKSPAEAKSPAEVKSPATVKSPGEAKSPAEAKSPAEVKSPVEAKSPAEAKSPASVKSPGEAKSPAEAKSPAEVKSPATVKSPVEAKSPAEVKSPVTVKSPAEAKSPVEVKSPASVKSPSEAKSPAGAKSPAEAKSPVVAKSPAEAKSPAEAKPPAEAKSPAEAKSPAEAKSPAEAKSPAEAKSPVEVKSPEKAKSPVKEGAKSLAEAKSPEKAKSPVKEEIKPPAEVKSPEKAKSPMKEEAKSPEKAKTLDVKSPEAKTPAKEEAKRPADIRSPEQVKSPAKEEAKSPEKEETRTEKVAPKKEEVKSPVEEVKAKEPPKKVEEEKTPATPKTEVKESKKDEAPKEAQKPKAEEKEPLTEKPKDSPGEAKKEEAKEKKAAAPEEETPAKLGVKEEAKPKEKAEDAKAKEPSKPSEKEKPKKEEVPAAPEKKDTKEEKTTESKKPEEKPKMEAKAKEEDKGLPQEPSKPKTEKAEKSSSTDQKDSQPSEKAPEDKAAKGDK
What is the function of this protein?
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber.  NEFH has an important function in mature axons that is not subserved by the two smaller NEF proteins.  May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
What are the official names of this protein?
Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, axon.
Protein: SOX15_DROME
Sequence: MEPSYDHEHPHHLLTNYNSKKYPHVSRTPEYSHSTGSDYPEHGGYLTDGRLMHESNSDAGIYHVRQGSEHSSPSLHSPAIQSSGYENEHLNEAVLAAHSHSHSPMPMVSSAYVGGGTASGSLINSNIPLLGGGGNSVLNKFLSHPHAGMVGGGTGQMEDCTSHSPIEAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYRPGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQSKLRAMQPGGKEQSESSPNPGTGGSKSNPKLATPPLATASSSYTTPTDESTCNSTNQNHGQSTPGGLYEQPLKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTGGGYDNSLLLKKLTKPSPSRAAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVVAARGMYVTCNNRGLLDHGHSVKGTFYPPVSVSEDDNSTSMRNSISALQQHCNVVTSTPSSSGGTMPTSEMSSYTVSMADNCGNLRLSMNELSGNEYLPSANAYGMQYEDFLRYQSNDMDYSTSAVEHKETTSDSASGQKCLKYPDTNQNYDDYEAEAYSNAMLPATAASYYTQLPYPPTSLAAFPLQLAVPFQQTTSGAYGAQPIQSGYLHYGNYGGYEGMAQSQPQNQAPVHHQQASHSAPPSLSVPPNQTVTSNSAAISMQQHHHHHFGPAPGMVGVGVGVGVGVGVGEMLFEQQQRKDDEISNILAGVRKTCYSN
What are the official names of this protein?
Putative transcription factor SOX-15, Sox50E.
What are the subcellular locations of this protein?
Nucleus.
Protein: SP381_YEAST
Sequence: MSFRHFKRRLDTSSADESSSADEEHPDQNVSLTEKSASLSHSDLGGEILNGTGKNRTPNDGQESNESDGSPESDESPESEESSDNSDSSDSDDMRPLPRPLFMKKKANNLQKATKIDQPWNAQDDARVLQTKKENMIKNIDKANQVAKNYETMKLRLNTNYSTNEELIKQCLLLDDNDEVDSEKERQKWFERQNERKQKHRRIQLAKQRESEEYEAKRFEAMQKGKDGNTKYDVILDKEKEKLDHKKQRSAEKVEKSHNNNRYKITRTKNVEFGDLGKNSRDYEETEYSVI
What is the function of this protein?
Component of the spliceosome and rRNA processing machinery.  In association with the spliceosomal U4/U6. U5 tri-snRNP particle, required for splicing of pre-mRNA.
What are the official names of this protein?
Pre-mRNA-splicing factor SPP381, Suppressor of PRP38-1 mutation.
What is the protein family that this protein belongs to?
Belongs to the SPP381 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FTHS_METNO
Sequence: MPTDIEIARAATLQPISAIAEKIGIPDAALHPHGRHIAKIDHAHIASLEAKPEGKLILVTAISPTPAGEGKTTTTVGLGDALNRIGKKAVICLREPSLGPCFGMKGGAAGGGKSQVVPMEAINLHFTGDFHAITSAHSLAAALIDNHVYWGNELNIDVRRIAWRRVVDMNDRALRSITQSLGGVANGYPREDGFDITVASEVMAVFCLARDLADLEARLGRIVVAETRDRKAVTLADLKATGAMAVLLKDALQPNLVQTLEGSPALIHGGPFANIAHGCNSVIATRTGLRLGEYAVTEAGFGADLGAEKFIDIKCRQTGLSPSAVVIVATLRALKMHGGVEKKALGTENIAALEKGFVNLARHVENVRRFGLPVVVAVNHFHTDTEAELATLKALCRDKLDVEAITCRHWAEGGAGAEELARAVVALAEGGAPKTPNFVYPEDAKLTDKIRTIAQTLYGAADIQVESKAATKLAQFEKDGYGKLPVCMAKTQYSFSTDPNLMGAPSGHVVAVRDVRLSAGAGFVVVICGEIMTMPGLPKVPAAEGIHLDANGQIEGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: YAEP_ECOHS
Sequence: MEKYCELIRKRYAEIASGDLGYVPDALGCVLKVLNEMAADDALSEAVREKAAYAAANLLVSDYVNE
What are the official names of this protein?
UPF0253 protein YaeP.
What is the protein family that this protein belongs to?
Belongs to the UPF0253 family.
Protein: UBE2O_HUMAN
Sequence: MADPAAPTPAAPAPAQAPAPAPEAVPAPAAAPVPAPAPASDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEEGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGTNCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSVITQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPAKIAWECPEKNCAQGEGSMAKKVKRLLKKQVVRIMSCSPDTQCSRDHSMEDPDKKGESKTKSEAESASPEETPDGSASPVEMQDEGAEEPHEAGEQLPPFLLKEGRDDRLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTSRKKSIPLSIKNLKRKHKRKKNKITRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHIGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGAPHKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSTSGASSDEWEDDSDSWETDNGLVEDEHPKIEEPPIPPLEQPVAPEDKGVVISEEAATAAVQGAVAMAAPMAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIVEEEKMEAVPDVERKEDKPEGQSPVKAEWPSETPVLCQQCGGKPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPEGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSTGGWRLVNRIESWLETHALLEKAQALPNGVPKASSSPEPPAVAELSDSGQQEPEDGGPAPGEASQGSDSEGGAQGLASASRDHTDQTSETAPDASVPPSVKPKKRRKSYRSFLPEKSGYPDIGFPLFPLSKGFIKSIRGVLTQFRAALLEAGMPECTEDK
What is the function of this protein?
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950).  Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138).  Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153).  Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1.  Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950).  Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).
What are the official names of this protein?
(E3-independent) E2 ubiquitin-conjugating enzyme, E2/E3 hybrid ubiquitin-protein ligase UBE2O, Ubiquitin carrier protein O, Ubiquitin-conjugating enzyme E2 O, Ubiquitin-conjugating enzyme E2 of 230 kDa, Ubiquitin-conjugating enzyme E2-230K, Ubiquitin-protein ligase O.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: RS2_TOLAT
Sequence: MAKVSMRDMLQAGVHFGHQTRFWNPKMKPFIFGARNNVHIINLEKTVPMFDDALNYLSSVASKKGKILFVGTKRAATEAVKEAAANCEQFYVNHRWLGGMLTNWKTVRQSIKRLKDLEAQSLDGTFEKLTKKEALMRTREMEKLEKSLGGIKDMGGLPDVLFVIDADHEHIAIKEANNLGIPVVSIVDTNSNPDGVDYIIPGNDDAIRAVQLYLNAAADSIKTARELDIVVQAEQDGFVEAN
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: CEP57_BOVIN
Sequence: MAAASVSETSASQFSNILAEPSKSNGSMVRHSSSPYVVYPPDKPFLNSDLRRSPNKPTFAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSKETIEYKKVLDEQIPERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQNQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLRQEEQERKRMQAKAAQLQTGLEVNRLIYEDKATSCVPNTKRIKKKKSKPPEKKGSRNYFAVQPHYRLCLGDMPFVAGKSTSPSHAVVANVQHVLHLMKQHSKVLCNDRVVSSIPLAKQVSSRTGKSKKSATPPSSSSVNEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDNLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATRKTLDEEGNSSSRSTTTGTTNKKDFAKPRPGEKSRKNLQLLKDMQSIQNSLQSNSLCWDY
What is the function of this protein?
Centrosomal protein which may be required for microtubule attachment to centrosomes.  May act by forming ring-like structures around microtubules.  Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2 (By similarity).
What are the official names of this protein?
Centrosomal protein of 57 kDa, Cep57, Testis-specific protein 57, Translokin.
What is the protein family that this protein belongs to?
Belongs to the translokin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: RRF_BURP1
Sequence: MSVADIKKSVEQKMQRSIEAFKNDLAKIRTGRAHTGLLDHVQVDYYGSMVPISQVANLTLVDARTIGVQPWEKTMVAKVEKAIREADLGLNPATSGDLIRVPMPPLTEERRRELTKVVKSEGETAKVAVRNLRRDANEQLKKLVKDKEISEDDERRASDDVQKLTDKHVAEIDKLVQAKDAEIMTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADB_NEIMA
Sequence: MQTDCDVLIAGNGLAALTLALSLPESFRIVILCKNRLDDTASRHAQGGIAAAWSGEDDIEKHVADTLEAGAGLCNEAAVRTILSQGKPAIEWLLAQGVAFDRSHDGLHLTREGGHTCRRIAHVADYTGEAVMQSLIVQIRRRPNIRVYERQMALDIQTESGAACGLTVLDRRTQETYNIRASHTVLAGGGLGQIYAATTTPPECTGDAIAMAIRAGCAVENLEFIQFHPTGLARSSENGRTFLISEAVRGEGGILTNQAGERFMPHYDRRAELAPRDIVARAIAAEIAKQTQDFVSLDISHQPAAFVRRHFPSIHRHCLSQCGLDITRQAIPVRPVQHYTCGGIQTDPCGRTSLPQLYALGETACTGLHGANRLASNSLLECVVTARLCAQAIADGQAFQAEPFQRPSESLSAEAGIFSDDLQNTFSRPVLQTFNQRHLGILRNDTGLRRAIAQLQLWKQNQAEPHTASEYENRNLLECSLAVAQAAYRRRQNIGAHFNSDC
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase, LASPO, Quinolinate synthase B.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_GRAFK
Sequence: MLNFYNTKITVAGADEAGRGCLAGPVTAAAVILPIEFKNAVLNDSKTLNLKNRNFLKSLIEDEAITYGVAHVFMKEIDEINILNASILAMHRALQVLKFDPDHIIVDGNRFKPYQKIPHECIIKGDGKYMSIAAASILAKTYRDEFMEKIHEEFPDYNWKKNKGYPTKEHRAAIKKYGVTKYHRKSFKLLPDQLKIDF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGO3_BOVIN
Sequence: MEIGSAGPVGAQPLLMVPRRPGYGTMGKPTKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDATLPGEGGKDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKSTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIEMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQPSAHTYVHCTRSVSIPAPAYYAHLVAFRARYHLVDKERDSAEGSHVSGQSNGRDPQALAKAAQIHQDTLRTMYFA
What is the function of this protein?
Required for RNA-mediated gene silencing (RNAi).  Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them.  Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.  Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (By similarity).
What are the official names of this protein?
Protein argonaute-3, Argonaute3, Argonaute RISC catalytic component 3, Eukaryotic translation initiation factor 2C 3, eIF-2C 3, eIF2C 3.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Ago subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body.
Protein: GATA1_RAT
Sequence: MDFPGLGALGTSEPLPQFVDSALVSSTSDSAGFFSSGPESLDTASSSTSPNAATAAATALAYYREAEAYRHSPVFQVYPLLNSMEGIPGSSPYASWAYSKTALYPASTVCPSHEDAPSQTLEDPDGKNNNTFLETLKTERLSPDLLTLGTALPTSLPVTSSAYGGADFPSPFFSPTGSPLSSAAYSSPKFHGSLPLAPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRMIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSSLAGAGAAEGPAGGFMVVAGGSSSGNCGEVAPGLTLGTAGTAHLYQGLGPVVLSGPVSHLMSFPGPLLGSPTASFPTGPVPTTTSTSVVSPLSS
What is the function of this protein?
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development.  It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.  Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS.
What are the official names of this protein?
Erythroid transcription factor, Eryf1, GATA-binding factor 1, GATA-1, GF-1, NF-E1 DNA-binding protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: CX5C4_ARATH
Sequence: MANVQKIGKAVYKGPSVVKEIIYGITLGFAVGGLWKMHHWNNQRRTKEFYDLLEKGEISVVVEDE
What is the function of this protein?
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
What are the official names of this protein?
Putative cytochrome c oxidase subunit 5C-4, Cytochrome c oxidase polypeptide Vc-4.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5C family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.