PharMolix/UniProtQA huggingface dataset:
Protein: ENO_PSEMY
Sequence: MAKIVDIKGREVLDSRGNPTVEADVILEGGIVGSACAPSGASTGSREALELRDGDKSRYLGKGVLKAVANINGPIRDLLLGKDATDQQALDRAMIELDGTENKAKLGANAILAVSLAAAKAAAQAKGVPLYAHIADLNGTPGVYSMPVPMMNIINGGEHADNNVDIQEFMVQPVGAKNFADALRMGAEIFHHLKAVLKARGLNTAVGDEGGFAPNLASNEDALAAIAEAVANAGYKLGDDVTLALDCASSEFFKDGKYDLEGEGKVFDAAGFADYLAGLTQRYPIISIEDGMDESDWAGWKVLTDKIGAKVQLVGDDLFVTNTKILKRGIDEKIGNSILIKFNQIGSLTETLEAIQMAKAAGFTAVISHRSGETEDSTIADLAVGTAAGQIKTGSLCRSDRVSKYNQLLRIEEQLGGKAPYKGRAEFRG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RPOY_STRA5
Sequence: MIYKVFYQETKERNPRREQTKTLYVTIDAANELEGRIAARKLVEENTAYNIEFIELLSDKHLEYEKETGVFELTEF
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: F193A_HUMAN
Sequence: MKVRLLRQLSAAAKVKAPSGLQGPPQAHQFISLLLEEYGALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCSEDTYSTLLQRYQRSEEELRRVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWELFKQRRFIEEQLTNKKAVTGENNFTDTMRHMLSSRLSMPDCPNCNYRRRCACDDCSLSHILTCGIMDPPVTDDIHIHQLPLQVDPAPDYLAERSPPSVSSASSGSGSSSPITIQQHPRLILTDSGSAPTFCSDDEDVAPLSAKFADIYPLSNYDDTEVVANMNGIHSELNGGGENMALKDESPQISSTSSSSSEADDEEADGESSGEPPGAPKEDGVLGSRSPRTEESKADSPPPSYPTQQAEQAPNTCECHVCKQEASGLTPSAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYATPPFTHSKALPPAPVQNHTNKHQVFNASLQDHIYPSCFGNTPEWNSSKFISLWGSEVMNDKNWNPGTFLPDTISGSEILGPTLSETRPEALPPPSSNETPAVSDSKEKKNAAKKKCLYNFQDAFMEANKVVMATSSATSSVSCTATTVQSSNSQFRVSSKRPPSVGDVFHGISKEDHRHSAPAAPRNSPTGLAPLPALSPAALSPAALSPASTPHLANLAAPSFPKTATTTPGFVDTRKSFCPAPLPPATDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMDQISERESVVDHRRVEDLLQFINSSETKPVSSTRAAKRARHKQRKLEEKARLEAEARAREHLHLQEEQRRREEEEDEEEEEDRFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTRNFQAATESVPNSGNIHNGSLEQTEEPETSSHSPSRHMNHSEPRPGLGADGDAADPVDTRDSKFLLPKEVNGKQHEPLSFFFDIMQHHKEGNGKQKLRQTSKASSEPARRPTEPPKATEGQSKPRAQTESKAKVVDLMSITEQKREERKVNSNNNNKKQLNHIKDEKSNPTPMEPTSPGEHQQNSKLVLAESPQPKGKNKKNKKKKGDRVNNSIDGVSLLLPSLGYNGAILAHCNLRLPGSSDCAASASQVVGITDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQTRQRLSINWSNFSLKKATFAAH
What are the official names of this protein?
Protein FAM193A, Protein IT14.
What is the protein family that this protein belongs to?
Belongs to the FAM193 family.
Protein: VP39_BPAPS
Sequence: MIFERRNPVASANSTVDLRGSGHSLINLSASSGSNHLIRFSLADGTLITGDFSIHFQSLSADFIIDLSSAKCLAFVAIETSFA
What are the official names of this protein?
Putative protein p39.
Protein: RS10_ECO27
Sequence: MQNQRIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHLRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: Y00C_BPT4
Sequence: MLINATKVLSSSGFTNIEITGYNWFGCSENDFQHTGFRAIGPTGQKVEGTVCSGLFFKDSTIRFK
What are the official names of this protein?
Uncharacterized 7.2 kDa protein in Gp39-comCA intergenic region.
Protein: RLMH_BURP6
Sequence: MKLHIVAVGHKMPGWIASGFDEYAKRMPPELRIELREVKPELRSGSRTADSVMAAEQQRIEAALPKNARVVALDERGRDWTTMQLAQALPAWQQDGRDVAFVIGGADGLAPALKSRAELLLRVSSLTLPHGMVRVLLAEQLYRAWSITQNHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPB_ECOLC
Sequence: MTTLLNPYFGEFGGMYVPQILMPALRQLEEAFVSAQKDPEFQAQFNDLLKNYAGRPTALTKCQNITAGTNTTLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILEREGRLPDAVIACVGGGSNAIGMFADFINETNVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTEDGQIEESYSISAGLDFPSVGPQHAYLNSTGRADYVSITDDEALEAFKTLCLHEGIIPALESSHALAHALKMMRENPDKEQLLVVNLSGRGDKDIFTVHDILKARGEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: SYTC_SULIA
Sequence: MESYKPVWLKGAVILAINLIDKGYKPVAVGLGERDFYIDVKSDTSITLDEVKKAINENVLANVPIENNQIVYKGNKVSIIEDKVSISTNLNPKYFEILNISTHHPNPNEQYVRIRGVAFETEEQLKDYLTWLEKAEETDHRLIGEKLDLFSFHEEAGSGLVLFHPKGQTIRNELIAFMREINDSMGYQEVYTSHVFKTDIWKISGHYTLYRDKLIVFNMEGDEYGVKPMNCPAHILIYKSKPRTYRDLPIRFSEFGHVYRWEKKGELYGLLRVRGFVQDDGHIFLREDQLREEIKMLISKTVEVWHKFGFKDDDIKPYLSTRPDESIGSDELWEKATNALISALQESGLKFGIKEKEGAFYGPKIDFEIRDSLGRWWQLSTIQVDFNLPERFKLEYIDKDGIKKRPVMVHRAIYGSIDRFVAILLEHFKGKLPTWLSSVQVRVLPITDEVNEYAEKVLNDMRKRRIRAEIDYAGETLSKRIKNAYDQGVPYILIVGKKEASEGTVTVRARGNIEVRNVKFEKFLELLITEIAQRDVEQTTVKALK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also activates L-serine and transfers it to tRNA(Thr) but cannot deacylate incorrectly charged amino acid; unlike most archaea the editing function is found in a freestanding protein.
What are the official names of this protein?
Threonine--tRNA ligase catalytic subunit, Threonyl-tRNA synthetase catalytic subunit, ThrRS-cat.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EML1_ARATH
Sequence: METQIHQLEQEAYTAVLRAFKAQSDAISWEKESLITELRKELRVSDDEHRELLSRVNKDDTIQRIRDWRQGGASQITRHATIQPFDVLPSPTFSAARKKQKTFPSYNPSIGATGNRSFNNRLVSSGISGNESAEALIGRKVWTKWPEDNHFYEAIITQYNADEGRHALVYDIHAANETWEWVDLKEIPPEDIRWDGEESGVALNIGHGSASFRGNRRGQIHGGRGRGPRIHQPRRELVPPPTQQNGSGGRRTSSDDIELFNTDSLVKEVERVFDSTHPDPLELDKAKKMLKEHEQALIAAIARLADTSDGEMDGDPPYSHDHPMPQG
What is the function of this protein?
Probably involved in the regulation of chromatin states (Probable).  Contributes to RPP7-mediated and basal immunity, especially against Hyaloperonospora arabidopsidis isolate Hiks1.  Regulates negatively EDM2-dependent floral transition (PubMed:21830950).
What are the official names of this protein?
Protein EMSY-LIKE 1, AtEML1.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROE_XYLF2
Sequence: MPVSRFAVFGHPIAHSLSPRIHTEFGRQMGVVLDYLAFDVAPDAFRVSLEHFVAEGGCGANVTLPLKEAAFEVCTTLSARARRAGAVNTLSRVDGVWHGENTDGTGLVRNLTERHGLDLRGRRALLLGAGGAARGVAPALLDAGITEMVIVNRSPERADMLCDALGEPGKVSARYWGDLGDLGNFELIINATSIGNTSDMRTFSLPRSLLDSMTAAVDLNYGSAAVPFLAWAHAVETRYAIDGLGMLVEQAAESFSLWHGRRPDTDPVYTVLHSEYGVPGRS
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: MTNB_LEIBR
Sequence: MSVILPESHPEHPFNLIPELCRRFYDLGWATGTGGGISIKMGDNYYVAPSGVQKERIKSNEIFVLNSSQDIVEKPRTDKQLKMSECTPLFFNAYRMRNAGACLHTHSVKCVLISLLCDREFRISHIEMLKGISNNETKKALGFRDTLIVPIIENTDFEKDLTASMAECMEKYPESCAVLVRRHGMYVWSDTWQKAKGAVECIDYLMGLAIQMKQLGLEWEPKDVK
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Probable methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFGL_SYNY3
Sequence: MNNPTNESLRNVAIVGPYGSGKTTLLESVLWVSGSVSRKGNIKDGNTVSDSSPEAKARQMSVEVSVAGIDYENLRLNFLDCPGSIEFAQETYGALVGAGTAVIVCEADVSRVLTLAPLFKFLDDWAIPHLVFINKMDRAKQPFGEVLQALKSVSSRPLIPQQYPIYKGEELQGYIDLITEQAYQYHTGSAADPIALPAELAGAEHQARQEMLEALADFDDRLLEELLEEVEPPQAEIEADFKQELGADLIVPVVLGAAEQDFGVRPLLDVLIKEAPDPSVTAARRSLSTDGSGPVIAQVLKTYFTPQGRLSLARIWQGTLREADSLNGQRLGGIYRLFGNQQTPVQTATVGEIVGLARLENINTGTTLSTADVKPLPFVEPLPPVYGLAIAPEQRKDEVKLSTALGKLVEEDPSLTWEQNTETQEVILWGQGEIHLKVALERLERQYKLPMVSQQPQVPYKETIRKGTEVHGRYKHQTGGHGAFGDVYLTIKPLERGNGFSFSETIVGGVVPKQYIPGVEMGVREYLAKGPLGYPVVDIAVTLTDGSYHNVDSSEQAFKQAARLAMTEGMPQCNPVLLEPILSVNVTTPTEFTSRVLQLVSGHRGQILGYEARSDWKSWDQVAAHLPQAEMQNFIIELRSLTLGVGNFTWQSDHLQEVPDKFAPNLRPD
What are the official names of this protein?
Elongation factor G-like protein.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Protein: SPRTL_STRA3
Sequence: MDLVLSSQTDLTNYVKKVSIEDFGCQFLHTAHWNNRLRTTGGRFFPNDRHLDFNPKIYREFGIDIFRKIVRHELCHYHLYIQGKGYQHRDKAFKELLEKVDGLRYTPRVTAVKVNYHHYSCQSCGQVYRRRRRVNLRKFACGYCHGRLIESF
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_LEPBP
Sequence: MLAPKRVKFRKRQRGRLKGKDERGSYVAFGEFGLKAISSGRITARQIEAARITINRQVKRGGKLWIRIFPHLPITKKPAETRMGKGKGNPEFWIAEIRPGRVLFEMAGVDEETARKALHLAAFKLPVETSFVKRNVL
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: CYB_RICBR
Sequence: MSDNITPKTGKTNAIIEWIDYRLPVFSFLKHFSHYQTPKNLSYLWNLGSIAGIALVIQIITGVILAMHYTPHVDHAFDSVEKIMRNVNYGWLLRYTHAVGASMFFAAVYLHIARGLYYGSYKAPRELLWHIGIIIFLTMMATAFMGYVLPWGQMSYWGATVITNLFSAIPLIGKSIVTWLWGGFSVDNPTLNRFFSLHYLLPFIIVALVMLHLVALHQHGSNNPKGIDVKSPKDTIPFHPYYTVKDFVGFGVYFIIFAYFIFYEPNYLGHPDNYIPANPLVTPAHIVPEWYFLPFYAILRAVPSKLGGVLLMFGSIFVLFLLPWLDTSKVRSANYRPIYRIAFWIFMADCLLLGYLGGQPAEEPYITISRFAACYYFFHFLVALPLIGKYEKPLPLPEEL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
What are the official names of this protein?
Cytochrome b.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRE_HYPJE
Sequence: MATTSQLPAYKQDFLKSAIDGGVLKFGSFELKSKRISPYFFNAGEFHTARLARRIASAFAKTIIEAQEKAGLEFDIVFGPAYKGIPLCSAITIKLGDVAPQNLDRVSYSFDRKEAKDHGEGGNIVGASLKGKRVLIVDDVITAGTAKRDAIEKITKEGRHRRGIVVALDRMEKLPAADGDDSKPGPSAIGELRKEYGIPIFAILTLDDIIDGMKGFATPEDIKNTEDYRAKYKATD
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: HSCA_SHIDS
Sequence: MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLADHEGRHLLPSVVHYQQQGHSVGYDARTNAALDTANTISSVKRLMGRSLADIQQRYPHLPYQFQASENGLPMIETAAGLLNPVRVSADILKALAARATEALAGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADYIREQAGIPDRSDNRVQRELLDAAIAAKIALSDADSVTVNVAGWQGEISREQFNELIAPLVKRTLLACRRALKDAGVEADEVLEVVMVGGSTRVPLVRERVGEFFGRPPLTSIDPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPALPAGGAHIRVTFQVDADGLLSVTAMEKSTGVEASIQVKPSYGLTDSEIASMIKDSMSYAEQDVKARMLAEQKVEAARVLESLHGALAADAALLSAAERQVIDDAAAHLSEVAQGDDVDAIEQAIKNVDKQTQDFAARRMDQSVRRALKGHSVDEV
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU.
What are the official names of this protein?
Chaperone protein HscA, Hsc66.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: UL06_HCMVM
Sequence: MNGWAGVCLITHCLNTRSRTYVALNMLAFARTPRGVPSCLFNKVWVSRYALVLILMVCASESSTSWAVTSNGLPNCSTVTRTAGQDAELHGPAPLSCNVTQWGRYENGSTPVLWCTLRGSRMRVSLGHRVAFGCSWKTFFIYNVSESSGGTYYQKGYNCTDKHITLSCFNLTVVPRAVQSTTTVMTPTLVTNSTFSVSLVALRLTTNSSAFGHAIYQRQQRVENGTLSKNITNLAFTYGSWGVAMLLFAAVMVLVDLGLPQSAWRRWRSHVDDEERGLLM
What are the official names of this protein?
Uncharacterized protein UL6.
What is the protein family that this protein belongs to?
Belongs to the RL11 family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: VATD_CLOBA
Sequence: MAKLNVNPTRMELSKLKKRLTTSTRSHKLLKDKQDELMRQFINLVKYNNKLRKEVEDNLQGSLKDFVMARAVMSSEFLEEAIVYPKEHISVEVGEKNVMSVSVPVMNFKRQLEGDEGSIYPYGFANTSSELDDTLSKLYEILPQLLELAEVEKSCQLMANEIESTRRRVNALEYMTIPQLQETIKYIRMRLDENERSATTRLMKVKSMIEQRG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: RIMP_RHOPA
Sequence: MTEPTPAVPETDDLAEPRLVIEPGVAARFCAVAEPVLMAMGYRLVRIKVSGDAGCTVQIMAERPDGTMLIDDCEAVSRALSPVLDVADPIDRAYRLEISSPGIDRPLVRRSDFARYAGHLVKIEMAVPHQGRKRYRGLLDGVEGDAVRVQREGATKDEDPLVLLPMHDIGDARLVLTDELIAESMRRGKQAERDLKQSLGLAPEPPPHAKRSDPKKSHAPKRGPKAAKAPTKPKPQNTKQHRLAADKSRRGEIDTSEGD
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMLD_BURTA
Sequence: MKILVTGANGQVGWELARSLAVLGQVVPLARDEADLGRPETLARIVEDAKPDVVVNAAAYTAVDAAESDGAAAKVVNGEAVGVLAAATKRVGGLFVHYSTDYVFDGTKSSPYIETDPTCPVNAYGASKLLGELAVAETGGDWLTFRTTWVFAARGKNFLRTMLRLAKEREEMKIVADQFGAPTWARSIADGTAHALATAMRERAAGAFTSGVYHMTSAGQTSWHGFADAIVASWRAVPGAAPLAVSRIVPIPTSAYPVPARRPANSVLSNEALKERFGIELPDWRYAVGLCVRDLLSQ
What is the function of this protein?
Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS).  Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
What are the official names of this protein?
dTDP-4-dehydrorhamnose reductase, dTDP-4-keto-L-rhamnose reductase, dTDP-6-deoxy-L-lyxo-4-hexulose reductase, dTDP-6-deoxy-L-mannose dehydrogenase, dTDP-L-rhamnose synthase.
What is the protein family that this protein belongs to?
Belongs to the dTDP-4-dehydrorhamnose reductase family.
Protein: SOX5_HUMAN
Sequence: MLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN
What is the function of this protein?
Transcription factor involved in chondrocytes differentiation and cartilage formation.  Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1.  Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate.  Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes.  Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts.  Binds to the proximal promoter region of the myelin protein MPZ gene.
What are the official names of this protein?
Transcription factor SOX-5.
What are the subcellular locations of this protein?
Nucleus.
Protein: MGSA_BACLD
Sequence: MKIALIAHDRKKQDMIQLTTAYKDILKKHELFATGTTGLKITEATGLPVVRFQSGPLGGDQQIGALIAKNDIDLVIFLRDPLTAQPHEPDVSALIRLSDVYAIPLATNMGTAEILIRSVEEGAFEFRNIVHGRDRDA
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: EPO_SHEEP
Sequence: MGARDCTPLLLLLLSFLLFPLGLPVLGAPPRLICDSRVLERYILEAREAENATMGCAEGCSFSENITVPDTKVNFYAWKRMEVQQQALEVWQGLALLSEAIFRGQALLANASQPCEALRLHVDKAVSGLRSLTSLLRALGAQKEAIPLPDATPSAAPLRIFTVDALSKLFRIYSNFLRGKLTLYTGEACRRGDR
What is the function of this protein?
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass.  Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
What are the official names of this protein?
Erythropoietin.
What is the protein family that this protein belongs to?
Belongs to the EPO/TPO family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLNK_ECOL6
Sequence: MKLVTVIIKPFKLEDVREALSSIGIQGLTVTEVKGFGRQKGHAELYRGAEYSVNFLPKVKIDVAIADDQLDEVIDIVSKAAYTGKIGDGKIFVAELQRVIRIRTGEADEAAL
What is the function of this protein?
Involved in the regulation of nitrogen metabolism.  Regulates the activity of its targets by protein-protein interaction in response to the nitrogen status of the cell.  Involved in the regulation of the ammonium transporter AmtB so as to optimize ammonium uptake under all growth conditions.  In nitrogen-limited conditions, GlnK does not interact with AmtB, which remains active and imports ammonium.  When extracellular ammonium increases, GlnK associates tightly with AmtB in the inner membrane, thereby inhibiting the transporter activity.
What are the official names of this protein?
Nitrogen regulatory protein GlnK, Nitrogen regulatory protein P-II 2.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane. Note=During nitrogen limitation, GlnK is predominantly in its fully uridylylated state in the cytoplasmic fraction. In response to nitrogen shock, GlnK is deuridylylated rapidly and associates tightly with AmtB in the inner membrane.
Protein: RPPH_BURM1
Sequence: MLDREGFRPNVGIILLNARNEVFWGKRLREHSWQFPQGGIKYGETPMQAMYRELHEETGLLPEHVKIIGRTRDWLRYEVPDKFIKREVRGHYRGQKQIWFLLRMLGRDCDICLRATDHPEFDAWRWNEYWVPLDAVIEFKRDVYQLALTELSRFLRRPAQRADKPRGPRLPRYPRVIAAQPAETLTIVDTSVVCSEVEVEASTLDEMPPRVIVGK
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: HFA4D_ORYSJ
Sequence: MESSNLGGGGGGGGGGGPPPFLIKTYEMVEDAATNHVVSWGPGGASFVVWNPLDFSRDLLPKYFKHNNFSSFIRQLNTYGFRKIDPERWEFANEDFIRGHTHLLKNIHRRKPVHSHSLQNQINGPLAESERRELEEEINRLKYEKSILVADLQRQNQQQYVINWQMQAMEGRLVAMEQRQKNIVASLCEMLQRRGGAVSSSLLESDHFSKKRRVPKMDLFVDDCAAGEEQKVFQFQGIGTDAPAMPPVLPVTNGEAFDRVELSLVSLEKLFQRANDACTAAEEMYSHGHGGTEPSTAICPEEMNTAPMETGIDLQLPASLHPSSPNTGNAHLHLSTELTESPGFVQSPELPMAEIREDIHVTRYPTQADVNSEIASSTDTSQDGTSETEASHGPTNDVFWERFLTETPRSCLDESERQESPKDDVKAELGCNGFHHREKVDQITEQMGHLASAEQTLHT
What is the function of this protein?
Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE).
What are the official names of this protein?
Heat stress transcription factor A-4d, Heat stress transcription factor 10, rHsf10, Heat stress transcription factor 15, OsHsf-15, Protein SPOTTED LEAF 7.
What is the protein family that this protein belongs to?
Belongs to the HSF family. Class A subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YAAA_ECO8A
Sequence: MLILISPAKTLDYQSPLTTMRYTLPELLDNSQQLIHEARKLTPPQISTLMRISDKLAGINAARFHDWQPDFTPENARQAILAFKGDVYTGLQAETFSEDDFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENARGKDLYQFWGDIITNKLNEALAAQGDNVVINLASDEYFKSVKPKKLNAEIIKPVFLDEKNGKFKIISFYAKKARGLMSRFIIENRLTKPEQLTGFNSEGYFFDEDSSSNGELVFKRYEQR
What are the official names of this protein?
UPF0246 protein YaaA.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: MUTH_SHISS
Sequence: MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALAGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQVERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_DESAH
Sequence: MLKKIDPAQTESWKRLGRHYDGVKDLAMDDLFQQDPDRFKRLSMAFKDMVVDVSKNRITDKTLALLMDLARETGVKEAIAMMFRGDRINETEGRSVLHVALRNLADTPVLVDGKDVMPGVRGVLEQMRLFSTRVYSGQQTGYSNRTITDIVNIGIGGSDLGPKMVATALAPYARKGLNVHFVSNVDGTHIVETLKGLDPATTLFIIASKTFTTQETMTNAASARQWFLEGAGDPGHVAQHFVAISTNAAAVEAFGIDRDNMFGFWDWVGGRYSLWSAIGLSVACYIGFDNFKRLLKGGFDMDCHFRDTPLEQNIPVVLAMISIWYVNFFNFPTEAVLPYDQGLEYFPAYLQQACMESNGKSTDRNGNLVAHATSPIVWGEPGTNGQHAFYQLLHQGTQIVPCDFLVPAISHNPLGDHHALLVANCFAQAEALMKGRGEQEVTREMTAKGMDGEKLGRLLPHRVFHGNRPSNTIVFKQLTPEVLGAIIAMYEHKIFVQGVVWNIFSFDQWGVELGKALASQIFPELADHETVVTHDGSTNGLINVFKQMRSKTCRS
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.