PharMolix/UniProtQA huggingface dataset:
Protein: NUDC_ESCF3
Sequence: MDRIIEKLDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLVQQQRRHDMGSVRQVIDLDVRLFQLAGRGVQLAEFYRSHKYCGYCGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGDIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCRAEYE
What is the function of this protein?
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.  The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing.  Has preference for mRNAs with a 5'-end purine.  Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
What are the official names of this protein?
NAD-capped RNA hydrolase NudC, DeNADding enzyme NudC, NADH pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudC subfamily.
Protein: OBG_AZOC5
Sequence: MKFLDQAKVYVRSGDGGAGCVSFRREKFIEFGGPDGGNGGRGGDVWIECVDGLNTLIDYRYQQHFKAKKGEHGMGANRAGAKGSDVVLRVPAGTQVLDEDEETILADLTEVGQRIRLLSGGNGGFGNAEFKTSTNQAPRRANPGLEGQEKWIWLRLKLIADAGLVGLPNAGKSTFLAATTAAKPKIADYPFTTLHPGLGVVRVDGREFVLADIPGLIEGAHEGAGLGDRFLGHVERCRVLLHLVDGTCEHAGKAYKTVRQELVAYGGGLEDRVEIVALSKIDSLTPELLKQQKERLQRAAKKKPLLLSSQSGKGVPEALRALLAVIDEGREAEVAEARKTEWRPI
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK2_THAPS
Sequence: MSIRLYKSYTPGTRNRALSAFSEITTDKPEKSLVKKNHRNKGRNNRGVITIRHRGGGHKKQYRLIDFKRNKYNISAVVNSIEYDPNRNARIALLHFTDGEKRYILHPNNLNVGDTILSGKGISLDIGNSLPLEEIPLGSSVHNIELIPNRGGQIVRSAGTSAKILAKEGNYVTLRLPSKEIRLIRKECFATIGEVSNNDAFLIQSGKAGRTRWLGKRPTVRGSVMNPCDHPHGGGEGRTPIGRTRPLTPWGKPALGKKTRKTKKLSSAYILRRRS
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BL1S1_YEAS7
Sequence: MFLTFSMCVNWIIVKMPNRSEELDRLLDKIINSPHRTEASKTLQEIENNQSYILNVQLKKLLRLHDDSFKNKCVSPINYMLEKYTPYMGHTEALQKEAELVDRDLRIIEMTYQLIKKNRNSK
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit BLS1, BLOC-1 subunit BLS1, BLOS1-homolog.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: PRY1_CANAL
Sequence: MKQNYILSIILCYLLANVHSAPAIITVWQTVTDAQVAAGPTAAAPAANANANVQQAAAASAPAPAPVASPAAPAPASSAPQSSTPSSSGWLSNLFNSFFGGSDSDSSSGSDTASAAPASTSPQSSSSSSSSSGNSFLSFLSGLFGSGSSSSTPSSISQQQQQQQGSPASGSNSPNSAQPDAAAASNPVPQSNNNQGSGLGSGFGSGFGSGSGSDSDSGSGLPSASSSTIIQQQPSSSNIGSSSTSSSSSSSSSSSSSSSSSGDIYAAISQCDGIDASFASEILDAHNKYRAQHKVGDLSWDVDTYNYAKNNADNYDCSGVLTHTHGKFGENLAAGFKDGASTVAAWVDEPISYSDASFVYNHFTQVIWKGSTKVGCAYKDCRKSNWGLYVVCEYDPYGNVIGQGSKNVFP
What is the function of this protein?
Secreted protein that acts as a virulence factor during infections.
What are the official names of this protein?
Secreted protein PRY1, PRY family protein 1, Pathogenesis-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: VPS68_YEAST
Sequence: MEADDHVSLFRFPFKIPTFRGIRKGGVYLSGALYALGFWIFLDAVLYSRYSNASDVHVTFIDWIPFLCSTLGTLIVNSIEKNRLLQGALSSDGGAFGSGVGDLDSSMAWQARTVLFFGFALLAGGLSGSIVVLIIKFLVKDYNTYPTLGMGVNNVLGNVCILLSCVVLWIAQNVEDEYSYSLTL
What is the function of this protein?
Involved in vacuolar protein sorting.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 68.
What is the protein family that this protein belongs to?
Belongs to the UPF0220 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Mitochondrion.
Protein: ARHG2_CANLF
Sequence: MSRIESLTRARTERSRELASKNREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNSTALQSVSLRSKTTPRERPSSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFSDESPLGLRRILSQSTDSLNMRNRALSVESLIDEGAEVIYSELMSDFETDERDFAADSWSLAVDSSFLQQQKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLADLLISQFSGPSAERMRKAYSEFCSRHTKALKLYKELYARDKRFQQFIRKVTRSAVLKRHGVQECILLVTQRITKYPVLINRILQHSHGTDEERQDLTTALGLVKELLSNVDQDVHELEKGARLQEIYHRMDPRAQAPVPSKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLMLLMTDVLVFLQEKDQKYIFPALDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWVRVIQQSVRVCPSREDFPLIETEDEAYLRRIKMELQQKDKALVELLREKVGLFAEMTHFQVEEDSGGVALPALPRGLFRSESLECPRGERLLQDAIREVEGLKDLLVGPGVELLLTPRDPALLVDPDSGGSTSPGVTANGEARNFNGSIELCRTDSDSSQKDRNGNQLRAPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLARANSRDGEAGRVGPAPVAPDKQATELALLQRQHALLQEELRRCRRLGEERATEAGNLEARLRESEQARALLEREAEEARRQLAILGQSEPPPAEAPWARRPLDPRRRSLPAGDALYLSFTPPQPSRGHDRLDLSVTIRSVHRPFEDRERQELGSPEERLQDSSDPDTGSEEEGGGRLSPPHSPRDFTRMQDIPEETESRDGEPMVSES
What is the function of this protein?
Activates Rho-GTPases by promoting the exchange of GDP for GTP.  May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer.  Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases.  May stimulate instead the cortical activity of Rac.  Inactive toward CDC42, TC10, or Ras-GTPases.  Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens.  Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase.  Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.  Involved in neuronal progenitor cell division and differentiation.  Involved in the migration of precerebellar neurons (By similarity).  Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (PubMed:12604587).
What are the official names of this protein?
Rho guanine nucleotide exchange factor 2, Guanine nucleotide exchange factor H1, GEF-H1, Tight junction-associated guanine nucleotide exchange factor isoform A.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle. Note=Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (By similarity). Localizes to the mitotic spindle in mitotic cells, and to tight junctions in interphase cells (PubMed:12604587).
Protein: HEM1_PSEPK
Sequence: MAFLALGINHKTASVDVRERVAFTPEQLVDALQQLCRLTSSREAAILSTCNRSELYIEQDHLSADAVLQWLADYHRLSIDELRASAYVHEEHDAVKHMMRVASGLDSLVLGEPQILGQMKSAYAVAREAGTVGPLLGRLFQATFSAAKQVRTDTAIGENPVSVAFAAVSLAKQIFADLGRSQALLIGAGETITLVARHLHEQGVRRIVVANRTLERASILAEQFGAHAVLLADIPQELANSDIVISSTASQLPILGKGAVESALKQRRHKPIFMVDIAVPRDIETEVGELDDVYLYTVDDLHDVVAENLKSRQGAAQAAEELVSVGAEDFMLRLRELAAVDVLRAYRQQSERLRDEELQKALRLLANGGNPEDVLAQLARGLTNKLLHAPSVQLKKLSAEGRLDALAMAQELFALNEGSTDKSPQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: KIF1A_ANOGA
Sequence: MSSVKVAVRVRPFNSREIARESKCIIEMAGNTTCITNPKVPPGSSESVKRFNYDYSYWSHDPRDLEFSTQAMVYSDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGKQEDGQEGVIPMICKDLFRRIQETESDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLKVREHPLLGPYVEDLSKLAVTSYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQKRQDRMTSLETEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEIASKNKKSKKADFIPYRDSVLTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRELLKAEGIEVQEGEDGEKKIHSPNRNRKRTGSSTEMAVDQLQASEKLIAELNETWEEKLKRTEQIRVQREAVFAEMGVAVKEDGITVGVFSPKKSPHLVNLNEDPTLSECLLYYIKDGLTRLGTSEANVPQDIQLSGSHILKEHCVFENKDGVVTLVPHKDALVYVNGRKVIEPEVLQTGSRVILGRNHVFRFTHPEQAREKREKNKEVDVCETPGNSGEIADWNFAQCELLEKQGIDLKAEMEKRLLALEEQYKREKRAADQEFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDIFVNPLFESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELTPAPAVGALTNGGQEDEFGQNPIPRTTVAVEVTDTKNGATHYWSLEKLRQRLELMREMYHNEAELSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFVYLSNLLYPVPLVHKVAIVNERGDVRGYLRVAVQPVMDEENADFSNGVKQSARILFDEEQNGQHKVPKIRTIPDKDEKYIEGGNEMGTKLEELEQEDADSGRGDSSVASELHESNDQEPGEHLQPGKEFTFRVTVLQATGIAAEYADIFCQFNFLHRHEEAFSTEPVKNSGSGAPLGFYHVQNITVPVTKSFIEYLKTQPIVFKVFGHYQHHPLHKDAKQDCQITRPPPRRMLPPSIPISQPVRSPKFGPLPCPPSSTVLAKHDVLVWFEICELAPNGEYVPAVVDHSDDLPCRGLFLLHQGIQRRIRITIVHEPTPEVKWKDIRELVVGRIRNQPEPADDEDSDSCVLSLGLFPGEVLEVPGDDRSFFRFEAAWDSSLHNSALLNRVTQTGEQIYITLSAYLELDNCARPAIITKDLSMIIYGRDARTGPRSLKHLFSGQYRNPEANRLSGVYELSLRRASEAGSPGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTRLEEVGRVRHLLLLRERLGMDTTPNPTTKTEKDVCNLAQRASASPVHMVIPPSPQTPVKDQQAPAMPERELSVRETELVWKCVKLIQGRIGCKELGAEGNGSGTQASDASPGDEGCADMNASYISSNSIELCSPERVDMPNGWEAPAPAPQTQDLSLRLYVPELEEIRVSPVVARKGYLNVLEHGGSGWKKRWVTVRRPYVFIFRSDKDPVERAVLNLATAQVECSEDQAAMVKVPNTFSVVTKHRGYLLQTLGDKEVHDWLYAINPLLAGQIR
What is the function of this protein?
Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons.
What are the official names of this protein?
Kinesin-like protein unc-104.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Microtubule-associated.
Protein: GLCTK_RAT
Sequence: MAAALQVLPCLLRAPSRPFLWGPPVARMTSGMALAEQARQLFDSAVGAVQPGPMLQRTLSLDPSGKQLKVRDRTFQLQENLYLVGFGKAVLGMAAAADELLGQHLVQGVISVPKGIRAAVELAGKQEMLLKPHSHIQVFEGAEDNLPDRDALRAAQAIQQLAERLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTKLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVIGDPLEVIASGPTVASTHSVQDCLHILNHYGLRAALPRSVKTVLSRADSDPHGPHTCGHVLNVIIGSNSLALAEAQRQAEVLGYHAMVLSTAMQGDVRRVAQFYGLLARVAAACLTSSTAERPLEEEAKLHQLAAELQLPDLQLEEALEAVAKAKGPVCLLAGGEPTVQLQGSGKGGRNQELALRVGAELGKQPLGPVDVLFLSGGTDGQDGPTKVAGAWVMSDLVSQASAENLDFATFLDNNDSYTFFCSFQGGTHLLHTGLTGTNVMDVHLLVFHPQ
What are the official names of this protein?
Glycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the glycerate kinase type-2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAL_BREBN
Sequence: MRFLIDTANVEEIREIHEWGVLAGVTTNPSLVAKEGRDFVETLKEILDIVDGPISAEVISTDAKGMIEEGEKLAALSKNIVIKLPMTAEGLKATKYFAKRKIRTNVTLVFSANQALLAARAGASFVSPFLGRLDDIGQDGMQLIEDIAEIFSVHGIDTEIIAASVRHPVHVTEAARRGSHFATIPAKVFKQLIAHPLTDSGLEKFLADWASMQK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CITG_STRPF
Sequence: MTKAVLTSISQLALKALLYEVSLSPKPGLVDRFDNGAHDDMSFMTFIDSMIALSPFFQAYIETGFAYAKEEPLLLFNRLRQLGQKAEETMFCATQGINTHKGLNFSMALLLGATGAYLARTPHLMTDLGRFSKEDTLAICRLVKPMTAHLIQTDLGHLNTKKEFTYGEQLFVTYGIKGPRGEASEGFTTLTDHALPYFRQMISQNDPETSQLRLLVYLMSIVEDGNLIHRGGIEAWKGVKADMRLLLQQDLSTTDLRLALSSYNQCLINQHLSPGGAADLLALTFYFAFLEKLL
What are the official names of this protein?
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: POTA1_PSEAE
Sequence: MSALHSLRTHAVSIRAVRKVYGDPESGPVALKRVDLDIRDNEFFTLLGPSGCGKTTLLRMIAGFEFPTEGEILLYGENIAARPPFERPVNTVFQHYALFPHMSIAENLAFGLESRPLGRSLGKAEIAERVREMLALVQMERFADRRPGQLSGGQQQRVALARALAPQPRVLLLDEPLSALDLKLRQAMREELKAIQAKTGITFIFVTHDQEEALTMSDRIAVLSEGQVQQVGPPEEIYERPGNRFVADFIGETNFIEAELLQRDGPLALYRGPGGEAFEAAARDGLAAGARVCLSIRPERLDLLAANTGGGLPCTVESQVYLGTDLQYRVRLADGSLLTVRTPNGTARRFATGEAACLAVAKDSASVLLD
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CHED_CLONN
Sequence: MNKDEIRIGIADLNVALPPKKLITVGLGSCIGIALYDSIKKIGGLAHIMLPDSTQFSNVSNPMKFADLAIPMLLEKMEKQGAVKRHLKAKIAGGASMFNFSDKSMIMDIGNRNSKSVKKVLGEYGIPIISEDTGGNKGRTMIFSTEDGMVEIRTVGMGIRAI
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: GTRB_BPSFX
Sequence: MKISLVVPVFNEEEAIPIFYKTVREFEELKPYEVEIVFINDGSKDATESIINALAVSDPLVVPLSFTRNFGKEPALFAGLDHTTGDAVIPIDVDLQDPIEVIPRLIEKWQAGADMVLAKRSDRSTDGRLKRKTAEWFYKLHNKISTPKIEENVGDFRLMSREVVENIKLLPERNLFMKGILSWVGGQTDVVEYVRTERVAGISKFNGWKLWNLALEGITSFSTFPLRVWTYIGLFVASISFLYGAWMIIDTIVFGNPVRGYPSMLVSILFLGGVQLIGIGVLGEYIGRIYLETKSRPRYLIKSRK
What is the function of this protein?
Involved in O antigen modification.  Catalyzes the transfer of the glucose residue from UDP-glucose to a lipid carrier.
What are the official names of this protein?
Bactoprenol glucosyl transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GtrB subfamily.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: TRI74_HUMAN
Sequence: MAWQVSLLELEDWLQCPICLEVFKESLMLQCGHSYCKGCLVSLSYHLDTKVRCPMCWQVVDGSSSLPNVSLAWVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVCSRMKEELAALFSELKQEQKKVDELIAKLVKNRTRIVNESDVFSWVIRREFQELRHPVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHEFIWKFHSMASR
What are the official names of this protein?
Tripartite motif-containing protein 74, Tripartite motif-containing protein 50C.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
Protein: FENR3_LYSSC
Sequence: MQHVYDVTIIGGGPAGLYSAFYSGLRGLKTKLIESQSQLGGKVLLYPEKLIWDIGGQPPILGEKFVKQLIQQAKTFDPTILTNTKVDFIERQEHLFIVHTATGERHYSKTVLLAVGGGIINPQKLTLEGAEKYEMSNLHYTVQSYKRFVNRDILISGGGNAAIDWAVELSPLAKSVTVVYRKDTLSAHEATVKEAIDAGVLIECNTTITKLLANDDKTAIQLVRCENSKTKESYTRQIDEVIISHGYNCEASLTFDEAISIPKKDDYYFEGKATGETAQPGIFAAGDILSFEGKINLLLGTFQDAANAVNSIKTYLEPTAYRHGMVSSHNELFKEKNRSIIEKELVPSH
What are the official names of this protein?
Ferredoxin--NADP reductase 3, FNR 3, Fd-NADP(+) reductase 3.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: LEP_BACCL
Sequence: MTKQKEKRGRRWPWFVAVCVVATLRLFVFSNYVVEGKSMMPTLESGNLLIVNKLSYDIGPIRRFDIIVFHANKKEDYVKRVIGLPGDRIAYKNDILYVNGKKVDEPYLRPYKQKLLDGRLTGDFTLEEVTGKTRVPPGCIFVLGDNRLSSWDSRHFGFVKINQIVGKVDFRYWPFKQFAFQF
What are the official names of this protein?
Signal peptidase I, SPase I, Leader peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: PHOU_STRPN
Sequence: MRNQFDLELHELEQSFLGLGQLVLETASKALLALASKDKEMAELIINKDHAINQGQSAIELTCARLLALQQPQVSDLRFVISIMSSCSDLERMGDHMAGIAKAVLQLKENQLAPDEEQLHQMGKLSLSMLADLLVAFPLHQASKAISIAQKDEQIDQYYYALSKEIIGLMKDQETSIPNGTQYLYIIGHLERFADYIANICERLVYLETGELVDLN
What is the function of this protein?
Plays a role in the regulation of phosphate uptake.
What are the official names of this protein?
Phosphate-specific transport system accessory protein PhoU homolog, Pst system accessory protein PhoU homolog.
What is the protein family that this protein belongs to?
Belongs to the PhoU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BDNF_CANLF
Sequence: MTILFLTMVISYFGCMKAAPMKEASVRGQGSLAYPGVRTHGTLESVSGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
What is the function of this protein?
Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity).  During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems.  Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology.  Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.  The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted. SUBCELLULAR LOCATION: [BDNF precursor form]: Secreted. Note=A proportion of BDNF is secreted as immature precursor (proBDNF).
Protein: RNFB_ALISL
Sequence: MSSILIAVIAISALALVFGLILGFASIKFKVESDPIVDQIDSILPQTQCGQCGYPGCKPYAEAIANGDTINKCPPGGQATIEKLADLMGVDIPSSAHDEEKSIKKIAFIHEDMCIGCTKCIQACPVDAIVGGTKALHTVIEAECTGCDLCVAPCPTDCIEMIPVNTTPDNWKWDLNTIPVVNLPADKPTKASEL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: RL4_POLSJ
Sequence: MQVELLNDQGLASSKVDVPDTVFGREYNESLIHQVVVAFQANARQGTRAQKDREQVRHSTKKPFKQKGTGRARAGMTSSPLWRGGGRIFPNMPDENFTQKINKKMYRAGMASIFSQLAREGRLAVVDSLAVDSPKTKVLADKFKAMNLNSVLVIADVVDENLYLASRNLVNILVVEPRYADPVSLVHYKKVLVTKAAMDQLKEMFA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: NTAN1_ARATH
Sequence: MIYVGGVQFLDESSSFSLSSSSQGSSLLVDVMSHPVITLASDSFKNLEEKNVSFDESDSESSTKDRYVYIFQREFAVVNPALVDFVGTDEATTCVGLVIRNRKSGMTSVAHMDSPEIVDLGISQMLLLVLQDDVDAELDVHMVGGYEDVDIKNADGVGDYAKPEGYSFPLCCKLVETLQKRRENFHIQTLFILGHNTKLDSQANTCPIFNGCLVNTSTGAILPASFNRTSRCPDEIVRRIRVSSSFEDSSWKGKLLDTYDTKTDRFIIAPCRWTMRLIEYVWELNQLTDEEILTNCSTSPSAEGPDFVNSLRRNWGYLLKYPEWSKTFPRRQPRVFERTVDGHWKKC
What is the function of this protein?
N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate.  Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn.  These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH).  Conversion of the resulting N-terminal asparagine to aspartate by NTAN1 renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.  This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position (By similarity).  Does not seem to be involved in immune response, unlike the N-terminal glutamine amidohydrolase NTAQ1 (PubMed:30117535).
What are the official names of this protein?
Protein N-terminal asparagine amidohydrolase, Protein NH2-terminal asparagine amidohydrolase, Protein NH2-terminal asparagine deamidase.
Protein: UBIC1_PSEE4
Sequence: MDNLWTSLPLPGLSDDQRHWLFAPGSLTLRLKALGRFSLEVTQQRIDFPEPGEAHALGCTTDSPAWIREVALKIDDQVMVCARSLTPMRERRPAWPELAGYGGEPLGSMLYNTPDIHRGAFECQRPQADDPLSRLATSLGQPSGKLLARRSRFLRDGQPLLIAECFVEGFWALLQERSAPLKLAI
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase 1, CL 1, CPL 1.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_CHLSY
Sequence: MRTLTVHYLGQIAYTAAWDIQRQLAAERSRGQIGDTLLLLEHPPTITLGNKARPDHVLASPAELAARGVAVVQSDRGGEVTYHAPGQLVAYPIFKLSQHGSDVGRYVRGLEESVIRVLAGYGLVGERVAGLTGVWVRNGAAKICAIGVKLSASGVTTHGLALNVDPDLSGFDLIVPCGITDRSVTSLAFELGQAPALAEVAERLIAQIGEVFALEPRVEALAM
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3188_MYCTU
Sequence: MAVTLDRAVEASEIVDALKPFGVTQVDVAAVIQVSDRAVRGWRTGDIRPERYDRLAQLRDLVLLLSDSLTPRGVGQWLHAKNRLLDGQRPVDLLAKDRYEDVRSAAESFIDGAYV
What is the function of this protein?
Probable antitoxin component of a type II toxin-antitoxin (TA) system.  Neutralizes the activity of cognate toxin Rv3189 by blocking access to the toxin active site.
What are the official names of this protein?
Probable mycobacterial cidal antitoxin Rv3188.
What is the protein family that this protein belongs to?
Belongs to the MbcA/ParS/Xre antitoxin family.
Protein: RL4_PROMA
Sequence: MANCAVLDWQGKEAGKASLNLKVAKDSSAVDLMHRAVLRQQAHSRQGTASTLTRAEVRGGGRKPYKQKGTGRARQGSIRTPLRPGGGIIFGPKPRQYNLSMNRKERRLALRTALMARFNDVIAVKDFGSKLKVPKTKEIQDFLARLDISSNSKVLIILSQPSDIIRRSVRNLEKVKLIAAEHLNVFDLLNANSLIIGEDALGKIKEVYGDD
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.