PharMolix/UniProtQA huggingface dataset:
Protein: RR7_COFAR
Sequence: MSRRGAAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIRGVTPDITVKARRVGGSTHQVPIEIGSTQGKALAIRWLLAASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DNAG_METST
Sequence: MVKDEITTTKYLIHSQINAKGFVEKPDVVGAIFGQTEGLLSDSLDLRELQKTGRIGRIKVDMTNRSGRTKGEIIIPSSLDRIETTILAASLETINRVGPCEANLRVTKIEDVRAVKRRTIVERAKELYQNMMEEFTPESSRMIDEVKESIRRPEIIEYGEDNLPAGPNTPTSDAILIVEGRSDVLNLLKYGIKNTIAVEGVNVPKTVADLTKKRTVTAFLDGDRGGDLILKELLQIGDIDYVTRAPRGLEVEYLDKDQVIYALKNKTSVDKITSHANYNHNQHRYHNKPKSHDKFESKLHEVTSSVNKTDKYSQKNESKQFKQQKNENKQVKDNSKEKTQKSTEKHNETEETHLNKYELMLKELSGTGKGRLYDMDFNLLKEVKVSDIYNEVKNSKETIKNIVFDGIITQRIVDLSKEKNIECLVAVKMSEVVKKPETIKIITK
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Also part of the exosome, which is a complex involved in RNA degradation.  Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.
What are the official names of this protein?
DNA primase DnaG.
What is the protein family that this protein belongs to?
Belongs to the archaeal DnaG primase family.
Protein: ADDA_STAA9
Sequence: MTIPEKPQGVIWTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPANAHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILDPAFIELTEQLSSDRSDDQFRMIIKQLYFFSVANPNPTNWLDQLVTPYEEEAQQAQLIQLLTDLSKVFITAAYDALNKAYDLFSMMDGVDKHLAVIEDERRLMGRVLEGGFIDIPYLTDHEFGARLPNVTAKIKEANEMMVDALEDAKLQYKKYKSLIDKVKNDYFSREADDLKADMQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDGSPSEIAESYRQHFQEILVDEYQDTNRVQEKILSCIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTIDGDGTGRRIDLSQNFRSRKEVLSTTNYIFKHMMDEQVGEVKYDEAAQLYYGAPYDESDHPVNLKVLVEADQEHSDLTGSEQEAHFIVEQVKDILEHQKVYDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQFKEDELAQIRILSPNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLIGGRGRRANLYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDFGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYSGLSKDFNKRDLKQPVILNQQFGLGMDYFDVDKEMAFPSLASVAYKAVAEKELVSEEMRLVYVALTRAKEQLYLIGRVKNDKSLLELEQLSISGEHIAVNERLTSPNPFHLIYSILSKHQSASIPDDLKFEKDIAQVEDSSRPNVNISIIYFEDVSTETILDNNEYRSVNQLETMQNGNEDVKAQIKHQLDYQYPYVNDTKKPSKQSVSELKRQYETEESGTSYERVRQYRIGFSTYERPKFLSEQGKRKANEIGTLMHTVMQHLPFKKERISEVELHQYIDGLIDKHIIEADAKKDIRMDEIMTFINSELYSIIAEAEQVYRELPFVVNQALVDQLPQGDEDVSIIQGMIDLIFVKDGVHYFVDYKTDAFNRRRGMTDEEIGTQLKNKYKIQMKYYQNTLQTILNKEVKGYLYFFKFGTLQL
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: HPT_MOUSE
Sequence: MRALGAVVTLLLWGQLFAVELGNDAMDFEDDSCPKPPEIANGYVEHLVRYRCRQFYRLRAEGDGVYTLNDEKQWVNTVAGEKLPECEAVCGKPKHPVDQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAKNLFLNHSETASAKDITPTLTLYVGKNQLVEIEKVVLHPNHSVVDIGLIKLKQRVLVTERVMPICLPSKDYIAPGRVGYVSGWGRNANFRFTDRLKYVMLPVADQDKCVVHYENSTVPEKKNLTSPVGVQPILNEHTFCAGLTKYQEDTCYGDAGSAFAIHDMEEDTWYAAGILSFDKSCAVAEYGVYVRATDLKDWVQETMAKN
What is the function of this protein?
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine.  Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage.  Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response.  Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
What are the official names of this protein?
Haptoglobin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLGC_AGRFC
Sequence: MSEKRVQPLARDAMAYVLAGGRGSRLKELTDRRAKPAVYFGGKARIIDFALSNALNSGIRRIGVATQYKAHSLIRHLQRGWDFFRPERNESFDILPASQRVSETQWYEGTADAVYQNIDIIEPYAPEYMVILAGDHIYKMDYEYMLQQHVDSGADVTIGCLEVPRMEATGFGVMHVNEKDEIIDFIEKPADPPGIPGNEGFALASMGIYVFHTKFLMEALRRDAADPTSSRDFGKDIIPYIVEHGKAVAHRFADSCVRSDFEHEPYWRDVGTIDAYWQANIDLTDVVPDLDIYDKSWPIWTYAEITPPAKFVHDDEDRRGSAVSSVVSGDCIISGAALNRSLLFTGVRANSYSRLENAVVLPSVKIGRHAQLSNVVIDHGVVIPEGLIVGEDPELDAKRFRRTESGICLITQSMIDKLDL
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: HNF4A_RAT
Sequence: MRLSKTLADMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHAHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAATPETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI
What is the function of this protein?
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (By similarity).  Activates the transcription of CYP2C38 (By similarity).  Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (By similarity).
What are the official names of this protein?
Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: AGRG5_MOUSE
Sequence: MDPHGALFFYLCLLAAQVVLVETLSDLLVLMKRLEQPVGRGLSSRARHIHSLEQKLLNASFGGHNLTLQTNSIQSLVFKLSCDFPGLSLSSTTLTNVSQVRAPHAMQFPAELTKGACVTSRPAELRLICIYFFTAHLFQDDRNSSLLNNYVLGAQLDHRPVNNLQKPVNISFWHNRSLEGYTVSCVFWKEGASKSSWGAWSPEGCYTEQPSATQVLCHCNHLTYFAVLMQLSGDPVPAELQVPLEYISFVGCSISIVASLLTILLYAQSRKQSDSTTRIHMNLNGSVLLLNVTFLLSSQMTLPTMPRPVCKVLAAVLHYALLSSLTWMAIEGFNLYLFLGRVYNAYIRRYLLKLCMLGWGFPALLVLLLLMIKSSVYGPCVTSLSKSQENGTGFQNVSMCWIRSPMVHSILVMGYGGFTSLFNLVVLAWALWILCRLRAREKALSPWAYRDTAMVLGLTVLLGTTWTLAFFSFGVFLLPQLFLFTIFNSLYGFFLFLWFCSQKRYSDAEAKAEMEAVSSSQMTH
What is the function of this protein?
Adhesion G protein-coupled receptor (GPCR).  Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway (PubMed:22575658).  Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking) (PubMed:26499266).
What are the official names of this protein?
Adhesion G-protein coupled receptor G5, G-protein coupled receptor 114, G-protein coupled receptor PGR27.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MOAC_VARPS
Sequence: MSSLTHFDAQGQAHMVDVAAKPATHRVAVATGRIEMQPATLALIESGTAKKGDVLGIARIAGIQAAKKTSDLIPLCHPLALTRVALAFALAEKGNAPQVVCTATVETVGPTGVEMEALTAVQVALLTIYDMCKAVDRGMRITDVHVLEKHGGKSGSYLADPQG
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: LUXS_LACLM
Sequence: MAEVESFQLDHTKVLAPYVRLIGSETGPKGDVITNFDVRFVQPNANAIGMAALHTIEHSMASLIRDRIDGMIDFSPFGCQTGFHMIMWGEHSSEEIAKVIKSSLEELSSDEFGWDNVPGVAEKECGNYRNHSLFGAKEWSKKILAEGISTDPYERKVI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: GSA1_STAHJ
Sequence: MKFTESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMREGHGAYLYDVDGNKFIDYLQAYGPIITGHAHPHITKAIQDQAAKGVLYGTPTELEIEFSKKLREAIPSLEKIRFVNSGTEAVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGPSQLGSPDSAGVPESVAKEVITVPFNDIESYKEAMKHWGDEVAAVLVEPIVGNFGMVEPQPGFLEKVNEITHDYGALVIYDEVITAFRFHYGAAQDLLNVYPDLTAFGKIIGGGLPIGGYGGRQDIMEHVAPLGPAYQAGTMAGNPLSMRAGIALLEVLEQNGVYERLDQLGKRLEDGLLELIDKHNITATINRVYGSLTLYFTDEKITHYEQVENSNGEAFAKFFKLMLNQGINLAPSKFEAWFLTTEHTEEDIDETLKAVDYAFSQMK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 1, GSA 1, Glutamate-1-semialdehyde aminotransferase 1, GSA-AT 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHCK_BACSU
Sequence: MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLACGLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSALYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYFWIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAADTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEFAVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLPILADQMLYKAKETGRNRVCFSEKKE
What are the official names of this protein?
Uncharacterized protein YhcK.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2856_BACLD
Sequence: MGREFIPLFENWANSYDDTVVGRDLQYKEVFRDYDGILDDVVSRSGHKVLEFGVGTGNLTAKLLAAGKAVTGVEPSKAMREIAEAKLPENAVIVDGDFIDFPDPPFSPDTIVSSYAFHHLTNEEKREAVKRYGKMLGKHGKIVFADTVFKNREAFSAAVKKAKENGFLQLAEDLETEHYPTISEMETIFTSEHFSIAFQKHNDFVWVMEAAKL
What is the function of this protein?
Could be a S-adenosyl-L-methionine-dependent methyltransferase.
What are the official names of this protein?
Uncharacterized methyltransferase BLi02856/BL02021.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. YrrT family.
Protein: TRKH_SALTY
Sequence: MHFRAITRIVGLLVILFSGTMILPGLVALIYRDGAGRAFTQTFFVALAIGSILWWPNRREKGELKSREGFLIVVLFWTVLGSVGALPFIFSESPNLTITDAFFESFSGLTTTGATTLVGLDSLPHAILFYRQMLQWFGGMGIIVLAVAILPILGVGGMQLYRAEMPGPLKDNKMRPRIAETAKTLWLIYVLLTVACALALWFAGMPAFDAIGHSFSTIAIGGFSTHDASVGYFDSPTINTIIAIFLLISGCNYGLHFSLLSGRSLKVYWRDPEFRMFIGVQLTLVVICTLVLWFHNIYDSALTTLNQAFFQVVSMATTAGFTTDSIARWPLFLPVLLLCSAFIGGCAGSTGGGLKVIRILLLFKQGNRELKRLVHPNAVYSIKLGNRALPERILEAVWGFFSAYALVFIVSMLAIIATGVDDFSAFASVVATLNNLGPGLGVVADNFASMNPVAKWILIANMLFGRLEVFTLLVLFTPTFWRE
What is the function of this protein?
Low-affinity potassium transport system.  Interacts with Trk system potassium uptake protein TrkA and requires TrkE for transport activity (By similarity).
What are the official names of this protein?
Trk system potassium uptake protein TrkH.
What is the protein family that this protein belongs to?
Belongs to the TrkH potassium transport family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL22_EHRCR
Sequence: MSKVLIVAKGMGLKSTPSKLNLVADLIRGKDVSVAMMYLKFCRKKSAGYISKVLKSAVANAQANYNIDLDNLYVKEVLVGKSFSLRRIHARARGKACRVYKHYGNVIIKLFERI
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: C71Z3_PASSA
Sequence: MEPVFLFLILAFPIASVYLLFYHKKRVVGLSAPPGPPGLPFIGNFHQLYKASSTHEYLWSLSKQYGSLVTLRMGSVPILVVSSPKMAKEVLQTQDLIYCSRPAMTGMQKLSYNGLDVAFSPYTDQWRHTRKFCTLELFTQKRAQLNFRPVREQEVSRMIARLSETAAASKDVNAYEWFSNLATCIISRVAFGKRYDEDGIGKERFQRMLSEIDAMFIGFFVSDFFPMFGWIDKLSGMRDRLDRTFKDLDMFYQELIDEHLKPNRLESPTEDLIDVMLKNEGSSLTKDSMKAILLNVFNGGTGTTATVLAWAMTALLRNQGVMKKAQEEIRSVIGKKGKVDEDDFPSLPYLRAVVKETMRLYPPAPVLVPRETMESSIIGEDKDHMYMVKPKTVVYISMWAIGRDPKTWKNPMEFVPERFLERPDINYKGQQFEYVPFGAGRRICAGINLGVTTVELALANLLYTFDWEPPAGMRFEDIDDETTNGLALQKKNALYIRPKKYMFP
What is the function of this protein?
Involved in the biosynthesis of coumarins and furanocoumarins (FCs), natural products required for defense responses against attacks by predators with potential medical and agroindustrial usages such as anticoagulant, rodenticide and artificial vanilla substitutes (PubMed:29971079).  Able to catalyze the hydroxylation of esculetin to produce 6,7,8-trihydroxycoumarin (PubMed:29971079).
What are the official names of this protein?
6,7,8-trihydroxycoumarin synthase, Cytochrome P450 CYP71AZ3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein.
Protein: AT1B3_MOUSE
Sequence: MTKTEKKSFHQSLAEWKLFIYNPSSGEFLGRTSKSWGLILLFYLVFYGFLAALFTFTMWAMLQTLNDEVPKYRDQIPSPGLMVFPKPQTALEYTFSMSEPQTYKKLVEDLESFLKPYSVEEQKNLTSCPDGAPFIQHGPDYRACQFPVSLLEECSGVTDANFGYSKGQPCILVKMNRIIDLIPDGYPQISCLPKEENATIATYPEFGVLDLKYFPYYGKKRHVGYRQPLVAVQVKFDSGLNKKEVTVECHIAGTRNLKNKNERDKFLGRVSFKVTARA
What is the function of this protein?
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.  The exact function of the beta-3 subunit is not known.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit beta-3, Sodium/potassium-dependent ATPase subunit beta-3, ATPB-3.
What is the protein family that this protein belongs to?
Belongs to the X(+)/potassium ATPases subunit beta family.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein: COAX_THERP
Sequence: MLMVIDIGNTNVVVGLFAGHELRARWRLATARDRMPDEWWVQLNVLSQSAGFSLGEVVGIAISSVVPSLTATFQELAQRYLLVEPLIVNGAQDYGLPVRVEHPAEVGADRICNAIAAVERYGAPVIVVDFGTGTTFDVIDADGAYIGGAIAPGITIAFEALTQRAARLYTVALQAPPRAIGRNTRESLQSGTVLGYAELVRGLIRRIRSELGHEAPAIATGGLATLIAPLVPEFSAVEADLTLYGLRSAYERMHRSLGA
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAFB1_PONAB
Sequence: MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSANLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSLDRKSASREKRSVVSFDKVKEPRKSRDSESHRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRAWQGTADGGMMDRDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHPIPHGGMQGGFGGQSRGSRPSDARFTRRY
What is the function of this protein?
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity).  Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (By similarity).  Thereby acts as a negative regulator of cell proliferation (By similarity).  When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity).
What are the official names of this protein?
Scaffold attachment factor B1, SAF-B1.
What are the subcellular locations of this protein?
Nucleus.
Protein: NAT10_ACHAM
Sequence: IHGDNKTRKGERKLHEERWQAASAAAHQHLSTPQTAAGGGRVLREVTLEMPIRYAPSDAVEKWLNNLLCLDCGSTPNRIIGGTPHPRECELYYVDRDSLFSYHKLSESFLQRIMALYVASHYKNQPNDLQLLSDAPAHHIFVLLGPQAEGQGNAGQLPDVLCVVQVALEGEISKESVAAQLSRGQRASGDLIPWTVAQQFQDNEFAGLSGARVVRIATHPDVTGMGYGSRAVELLTKYYQGELASGEFEEENEAAKPADEESDDESNLLKEKVKPRKALPPLLLPLTDRPAERLHWFGTSFGLTLQLYTFWQRSGFRSVYIRQTANPLTGEHTAIMLNALKCDDLPASPAAGWLDEFVGDARKRFMALLAYEF
What is the function of this protein?
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs.  Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA.  Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis.  Catalyzes the formation of ac4C in serine and leucine tRNAs.  Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
What are the official names of this protein?
RNA cytidine acetyltransferase, 18S rRNA cytosine acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PHS_PSEAB
Sequence: MTALTQAHCEACRADAPHVSDEELPVLLRQIPDWNIEVRDGIMQLEKVYLFKNFKHALAFTNAVGEISEAEGHHPGLLTEWGKVTVTWWSHSIKGLHRNDFIMAARTDEVAKTAEGRK
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: NRARP_XENLA
Sequence: MSQAEMSTCSMPHTQRVFQEAVRNGNTKELHSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANRDGWSALHIAAYGGHQDIVLYLITKAKYSSSSR
What is the function of this protein?
Promotes loss of intracellular domain (ICD) of Notch1 in embryos.  By down-regulating ICD levels, could function as a negative feedback regulator of Notch signaling that attenuates ICD-mediated transcription (PubMed:11485984).  Involved in angiogenesis.  May be involved in somitogenesis (By similarity).
What are the official names of this protein?
Notch-regulated ankyrin repeat-containing protein.
What is the protein family that this protein belongs to?
Belongs to the NRARP family.
Protein: TX35A_PHOKE
Sequence: CGDINAPCQSDCDCCGYSVTCDCYWSKDCKCRESNFVIGMALRKAFCKNK
What is the function of this protein?
Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav).  In vivo, is highly toxic to insects.
What are the official names of this protein?
U2-ctenitoxin-Pk1a, U2-CNTX-Pk1a, Neurotoxin PKTx20C2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 03 (Tx2) family. 05 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LPXD_SYNC1
Sequence: MATLNELAELIGGEVVGDGSVVLNRMAPIESAGPGDITFVANPKYLAKLKDTTASAVIVKAGIECPGVNLLICANPYLAFAKVLTALHAQRPAPQGVMDGAWVDPSAELGADVTVHPGCVVGKNVRVGRGTILYPGVVLYDDVQVGEDCLVHAGVLVREQCRLGNRVVVQPGAVIGSDGFGFAPDGKSYYKIPQVGIVAIEDDVEVGANVCIDRAAMGVTLIKRGTKIDNLVQIAHNVSIGEDTILVAQVGIAGSSKVGDHCTLGGQVGVSGHLKIGDNTMVGAQSGIISDLPAGQVFSGTPTMPHREWLKASASMRSLPAMRKTVSNLQKRIEELEKLIKER
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: MNMC_ACIAC
Sequence: MSEPIDWLPDGTPFNPRFGDRYHSHTGLAQAREVFLRGCGLPGAWAGQAMWRVLETGFGCGLNFLATWAAWRADPARPRLLHFVSCEAFPVSADDLLRSMQGHGELEPLARALHAQYWGLLPGVHRLAFEGGQVLLTLYIGDAQAMLRQQQPVADAVYLDGFSPQVNPELWDVHTLKAVARCCRRGTRLATWSVAGAVREGLAQCGFRVQKVPGLPPKRSNLQAEFDPAWEPRPVQPELPDVRVAGGPSSVLVIGGGLSGAAVAASLARRGWQVRVLDQGAEPAAGASGLPAGVFAPHVSPDDSLLSRLSRCGVRATLQALEASGLSEGEDWSACGVLEHEVDGKHRLPPAWAGDAAVGAEWSRPADAAALEAAGLPGATVAYWHARGGWLRPARLVRALLAHPGIHWQGRSAVARLEPVAAPGGATHWQAYGSDGTVLAEAPHVVVAAGYGSRPWLPARYPIHPLRGQVSWGTRADSPAAAWPPFPVNGHGNLVPHAGTAGGGIWVMGSTFERGQTELPPAPQEQAQAHAANAAKLEQLLPALAQGLAPAIAGPGAAPGHWAAVRCTAPDRLPFVGPVDAARQAGLWVCAAMGARGLTLSQLCGELLAARMMGEPLPVEVRLARALSTERLPAD
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.