PharMolix/UniProtQA huggingface dataset:
Protein: LSM8_MOUSE
Sequence: MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH
What is the function of this protein?
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).  The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm8.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NNRD2_PUCGT
Sequence: MMVHSPLATGPHPTTHLEPTMHQPHRSLLRKAFQMIPPLDGSLHKGQAGRIGIVGGSKDYTGAPFYSGYASLRLGSDLSHVICEPSASTVIKTYSPDLMVHSYLSSPKEPEAYASHQNQFEQLLDRLHVLVVGPGLGRDTEMQDWAEWTLKTAIQKKLHLVLDADALWLLVKKPDLLRGYPNAILTPNHVEFQRLLKACSIEPREHDDDGLLAMELSKALGGCSILQKGSIDLVAREGSEVAKVSCEGSPKRCGGQGDILSGLVGTWCAWTKLYFERQSQDEKPKSHELPISPEEAWIIAAVLGSEITRTCSRLAYHKFGRSMQSSDMLGYIGEAFEQVMHGHTKD
What is the function of this protein?
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP.  Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
What are the official names of this protein?
ATP-dependent (S)-NAD(P)H-hydrate dehydratase 2, ATP-dependent NAD(P)HX dehydratase 2.
What is the protein family that this protein belongs to?
Belongs to the NnrD/CARKD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_NICAL
Sequence: MEEIQRYLQPDRSQQHNFLYPLIFQEYIYALAHDHGLNRNRSILLENPGYNNKLSFLIVKRLITRMYQQNHFLISTNDSNKNSFLGCNKSLYSQMISEGFAFIVEIPFSLRLISSLSSFEGKKIFKSHNLQSIHSTFPFLEDNFSHLNYVLDILIPYPVHLEILVQTLRYWVKDASSLHLLRFFLHEYWNLNSLITSKKPGYSFSKKNQRFFFFLYNSYVYECESTFVFLRNQSSHLRSTSFGALLERIYFYGKIERLVEVFAKDFQVTLWLFKDPFMHYVRYQGKSILASKGTFLLMNKWKFYLVNFWQCHFSLCFHTGRIHINQLSNHSRDFMGYLSSVRLNPSMVRSQMLENSFLINNAIKKFDTLVPIIPLIGSLAKANFCTVLGHPISKPVWSDLSDSDIIDRFGRICRNLFHYYSGSSKKKTLYRIKYILRLSCARTLARKHKSTVRTFLKRSGSELLEEFLTSEEQVLSLTFPRASSSLWGVYRSRIWYLDIFCINDLANYQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TBA_OCTVU
Sequence: ICKRNLDIERPSYTNLNRLISQVVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLAVAEVTSACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVLGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGLDTFEAEEEEGGDEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: VM1_BOTCO
Sequence: TPEHQRYVELFIVVD
What is the function of this protein?
Snake venom metalloproteinase that impairs hemostasis in the envenomed animal.
What are the official names of this protein?
Snake venom metalloproteinase Bco22, SVMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRE_BRUSI
Sequence: MNTDDVLAVFREAGAILEGHFILTSGLRSPVFLQKARVFMHADKTEKLCKALAEKIRAADLGPIDYVVGPAIGGLIPSYETSRHLGVPSVWVERENGVFRLRRFDVPKGARVVIVEDIVTTGLSIRETIDCMKDLGIEVVAAACIVDRSAGKADVGTRLISLAEYEVPAYPADKLPPELAAIPAVKPGSRNI
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: VAMP8_MOUSE
Sequence: MEEASGSAGNDRVRNLQSEVEGVKNIMTQNVERILSRGENLDHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVIICVIVLIIVILIILFATGTIPT
What is the function of this protein?
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes.  SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion.  VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (By similarity).  Also required for dense-granule secretion in platelets (By similarity).  Also plays a role in regulated enzyme secretion in pancreatic acinar cells (PubMed:15363411).  Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity).  Involved in the homotypic fusion of early and late endosomes (By similarity).  Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (By similarity).
What are the official names of this protein?
Vesicle-associated membrane protein 8, VAMP-8, Endobrevin, Edb.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Zymogen granule membrane; Single-pass type IV membrane protein. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity). Sub-tight junctional domain in retinal pigment epithelium cells (By similarity). Midbody region during cytokinesis (By similarity). Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (PubMed:15363411).
Protein: RR4_WOOUN
Sequence: MGRGKTPNLGEFRVATDQSASRKISQFCVRLEAKQRLRFNYGLTERQLLKYVRIARKTRGSTGQVPPQLLEMRLDNVIFRLGMASTIPAARQLVNHRHILVNNRIVDVPSYRCKPKDIITVRNRPTSCNALKGESPGGGETPDHLTASLSEGSRPTGLVNRIANRESVNLNINELLVVEYYSRKA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PYRE_CAMFF
Sequence: MNLEDIYRDAGAYLKGHFLLSSANHSEYYLQSAKVLENPILAGKLADELFEVIKNAGVEFDSVCSPALGGILAGYELARAGAKRFIFTERVEKVMSLRRGFSVAKGEKFIICEDIITTGGSALESAKIIEELGGVVVGFAALANRGFCKVHNMRNEGKSSCKLPADKPLFALGNFEFEIYTPEECPLCKTGSKAIKPGSRGN
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: PGK_VIBC3
Sequence: MSVIKMIDLDLAGKRVFIRADLNVPVKDGKVTSDARILASLPTIKHCLEAGAKVMVTSHLGRPTEGEYAEEFSLLPVVNYLNDALDCEVRLVKDYLDGVELNAGELVVLENVRFNKGEKKNEEALSKKYAALCDVFVMDAFGTAHRAQASTHGVGMFAPIACAGPLLADELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLYEADLVETAKKLMEECAIPVATDVACAKAFDENAEAEIKHVSEVQDDDMIFDLGPNSTAELAEILKNAKTILWNGPVGVFEFKNFEAGTRGIAEAIAQSEGFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKKLPAVEMLEARAKA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL3_CALJA
Sequence: MSHLPILLLLLLVSPGLQAAPTQTMPLKTTQVNCSNLREEIVTLLNQPPLASSNFNNLNREDQRILMKPNLRKPNLEAFQKAVKSLQNAAAIESNLKDLPVCLPTATNAATQHPIRIKDGDWNDFQMKLKFYLKTLEIKQPQ
What is the function of this protein?
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
What are the official names of this protein?
Interleukin-3, IL-3, Hematopoietic growth factor, Mast cell growth factor, MCGF, Multipotential colony-stimulating factor, P-cell-stimulating factor.
What is the protein family that this protein belongs to?
Belongs to the IL-3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRHO_BRUMB
Sequence: MSNLPFTVAALYCFAPLPQYESLREPLAQLCCANGIKGTLLLAAEGINGTVAGSAGAIEKLIAHITAIPGLGEPELKYSHASEMPFHRMKVRLKREIVTMGVEGIDPLKSVGTYIAPKDWNALIADENTVVVDKRNDYEYAIGTFEGAIDPQTRTFREFPEWVKQNRDRLEGKKIAMFCTGGIRCEKATAFVKGLGFDDVYHLKGGILKYLEEVPREQSMWNGECFVFDERVAVGHGLAESDVELCRACRRPLTPQDKLSQFFEEGVSCAGCYAERTPEDRARYAERQKQVKLAEKRGANKHIGS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: KDSB_BRUA4
Sequence: MLQTLKTLTLIPARMASTRLPNKPLADICGKPMIVHVADRAAAAKLGRTVVATDSEEIFAIVTAHGHEAIMTREDHESGSDRIYEALMKVDPAGEFDAVVNVQGDLPTIDPDIIRRALLPLEDGPADIATLGVEIEEESEKTNPSVVKIVGSPLAGNSRLRALYFTRATAPYGEGPLYHHIGLYAYRRSALERFVKLGPSPLEKREKLEQLRALEAGMRIDVELVRTVPLGVDTQADLDRARILVAQGI
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_STAA8
Sequence: MPTINQLVRKPRQSKIKKSDSPALNKGFNSKKKKFTDLNSPQKRGVCTRVGTMTPKKPNSALRKYARVRLSNNIEINAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGALDTSGVDGRRQGRSLYGTKKPKN
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: FPOL_METMA
Sequence: MVKTALEEFAFLIPLLPALAFAITFFFGRKMPSGGAIVPILAIAASFVISFAITLGLLANPEEVISQSYSWFAVLNIGILIDPLAAVMLSMVSFVSLLIHIYAVSYMSHDAGKARYFAETALFTAAMLSLVLSDNILQLFVSWELVGLCSYLLIGFWFEKPSAAAAAKKAFLTTRIGDVMFLTGIIVLTSDLLKVSGGFQDGVYLLRFDEIFSYIPELAALQINILGFEISHLTIITLLFFGGAVGKSGQFPLHVWLPDAMEGPTTVSALIHAATMVTAGVYLVARTFPMFIAAPDSLMVVAYFGGFTALFAGTMGIVMNDLKRVLAFSTISQLGYMMLGLGLGTAIGLEAVGISLFHLINHAFFKALLFLCAGSVIHAVGTQDMRELGGVGKVMPITAATMTIAALALAGFGIPGTSIGTSGFMSKDPIIEAAYLFGEHSSNWIPYVFSILAALLTSIYIFRLIFMTFTGKPRSNYHGHESPAIMTIPLSILAIFALAFGALTRTGFMEFLEETFTNSFVNLDIGALAGIGENELVAAAGHEPLAVLWPPVIVALAGFAIAFVIYYLRAFSLGPLASMKNPIYRLLYNRYYQHQIYTEFFSIGIVYGIIAFLTQVVDVIIDSVVEGIGIVTVFVGEELRKIQTGVVQTYATALIAGVSLLIILVKLIMEVL
What is the function of this protein?
Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system.  The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines.  Catalyzes the oxidation of methanophenazine to dihydromethanophenazine.  It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane).  It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  It also catalyzes the oxidation of F(420)H(2) with quinones such as 2,3-dimethyl-1,4-naphthoquinone, 2-methyl-1,4-naphthoquinone and tetramethyl-p-benzoquinone.
What are the official names of this protein?
F(420)H(2) dehydrogenase subunit L, F(420)H(2)-dependent phenazine dehydrogenase subunit L, F(420)H(2)-dependent phenazine oxidoreductase subunit L, FPO subunit L, Methanophenazine hydrogenase subunit L, Methanosarcina-phenazine hydrogenase subunit L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CXCR1_HOOHO
Sequence: MWNITDPQGWDYDGDLYFTGMPPIDEDFSPCKLETETLNKYVVIITYALVFLLSLLGNSLVMLVILYSRVGRSVTDIYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCVGCWGLSMILSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLLVMLFCYGFTLHTLFKAHMGQKHRAMRVVFAVVLIFLLCWLPYNLVLFTDTLMRTQLIKESCERRKDISKALEATEILGFFHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHHVTSYTSSSVNVSSNL
What is the function of this protein?
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor.  Binding of IL-8 to the receptor causes activation of neutrophils.  This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
C-X-C chemokine receptor type 1, CXC-R1, CXCR-1, High affinity interleukin-8 receptor A, IL-8R A, IL-8 receptor type 1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TPIS_SALCH
Sequence: MRHPLVMGNWKLNGSRHMVNELVANLRKELTGVAGCDVAIAPPEMYIDLAKRAAAGSHIMLGAQNVDLNLSGAFTGETSAEMLKDIGAQYIIIGHSERRTYHKESDELIAKKFAVLKEQGLTPVLCIGETEAENEAGKTEEVCARQIDAVLKTQGAAAFEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRDHIAKADAKIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGASLKADAFAVIVKAAEAAKQA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFRNP_HALMA
Sequence: MVDRPLKQRFVLDTSLFLTPEIRSGDEDLEAACLDLLDLISEAKLVHNISCYMPPSIQAELTTMLEDRAISDEVLTKLDTWVITKSPAHHEVRIPADLVYEFIDEMSERVDRGLRVSEKAVRKAEESRAETVEEHDHMTEVDKVISDLRDEYRDTLRQGVLDSREDFDLLILAQELDAGVVTEDQGIINWAEDFGLRYLKGRNFPPLLREYLAADDPDRWRDES
What is the function of this protein?
RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.
What are the official names of this protein?
RNA-free ribonuclease P, RNA-free RNase P, Protein-only RNase P.
What is the protein family that this protein belongs to?
Belongs to the HARP family.
Protein: ENL14_ARATH
Sequence: MFLSASMASSSLHVAIFSLIFLFSLAAANEVTVGGKSGDWKIPPSSSYSFTEWAQKARFKVGDFIVFRYESGKDSVLEVTKEAYNSCNTTNPLANYTDGETKVKLDRSGPFYFISGANGHCEKGQKLSLVVISPRHSVISPAPSPVEFEDGPALAPAPISGSVRLGGCYVVLGLVLGLCAWF
What is the function of this protein?
May act as a carbohydrate transporter (PubMed:24470637).  Required, together with ENODL11, ENODL12, ENODL13, ENODL14 and ENODL15, for male-female communication and pollen tube reception and burst at the synergid cell surface of the female gametophyte (PubMed:27524487).
What are the official names of this protein?
Early nodulin-like protein 14, AtENODL14, Early nodulin like protein 1, Phytocyanin-like protein ENODL14.
What is the protein family that this protein belongs to?
Belongs to the early nodulin-like (ENODL) family.
Protein: KAX37_ORTSC
Sequence: GVIINVKCKISRQCLEPCKKAGMRFGKCMNGKCHCTPK
What is the function of this protein?
Blocks voltage-gated potassium channels Kv1. 1/KCNA1 (IC(50)=0. 6 nM), Kv1. 2/KCNA2 (IC(50)=5. 4 nM), Kv1. 3/KCNA3 (IC(50)=0. 014 nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3. 1/KCNN4 (IC(50)=225 nM) (PubMed:15588251, Ref. 1, PubMed:16234482).  Also shows activity on muscle-type nicotinic acetylcholine receptor (nAChR), since it reversibly and dose-dependently inhibits acetylcholine-induced current through mouse muscle-type nAChR heterologously expressed in Xenopus oocytes (IC(50)=1. 6 uM) (PubMed:31276191).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 3.7, OsK-1, OsK1.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 03 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL32_PROMM
Sequence: MAVPKKKTSKGKRNQRHAIWKAKAATAAQRALSIGKSVLSGRAQGFVYPMQESDDDES
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: SYI_CHLT2
Sequence: MDNEDKISISAKEEKILSFWKEQDIFQKTLDNREGCPTFSFYDGPPFATGLPHYGHLLAGTIKDVVCRYASMDGHYVPRRFGWDCHGVPVEYEVEKSLGLTEPGAIERFGVANFNEECRKIVFRYADEWKYFVDRIGRWVDFSATWRTMDLSFMESVWWVFRSLYDQGLVYEGTKVVPFSTKLGTPLSNFEAGQNYKEVDDPSVVVKFALQDNQGFLLAWTTTPWTLVSNMALAVHPELTYVRIKDKESGDEYILGQESLPRWFPDRESYEWIGQLSGKSLVGQSYEPLFPYFQDKKELGAFRILPADFIEESEGTGIVHMAPAFGEADFFACQEHNVPLVCPVDNQGCYTAEVKDFVGEYIKSADKGIARRLKNENKLFYQGTVRHRYPFCWRTDSPLIYKAVNSWFVAVEKVKSKMLKANESIHWTPGHIKQGRFGKWLEGARDWAISRNRYWGTPIPIWRSDDGELLVIGSIQELEALSGQKIVDLHRHFIDEIEINQNGKSFRRIPYVFDCWFDSGAMPYAQNHYPFERAEETEACFPADFIAEGLDQTRGWFYTLTVIAAALFDQPAFKNVIVNGIILAEDGNKMSKRLNNYPSPKMIMDAYGADALRLYLLNSVVVKAEDLRFSDKGVESVLKQVLLPLSNALAFYKTYAELYGFDPKETDNIELAEIDRWILSSLYSLLGKTRESMSQYDLHAAVNPFVDFIEDLTNWYIRRSRRRFWDAEDSTDRRAAFSTLYEVLVVFSKVIAPFIPFISEDMYQQLRGETDPESVHLCDFPHVVLEKILPNLERKMQDIREIVALGHSLRKEHKLKVRQPLQNVYIVGSQERMEALAQVGSLIGEELNVKDVHFCSETPEYVTTLIKPNFRTLGKKVGNRLPEIQRALAGLPQEQIQAFMHKGQMVVSLGEETISLDKEDITVSWASAEGFVARSSASFVAVLDCQLTEPLIMEGIARELVNKINTMRRNGKLHVSDRIAIRLHAPVIVQEAFALHKEYICEETLTTSVSVIDYKEGEEWDINGHAVSFVLERVER
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_GEOSM
Sequence: MVKDVISNMNVHMGKSIESLRKEYQKVRTGRATTSLLDDIKIDSYGTLSPLNQVATLAIPEARTITISPWDSKMIAPIEKAIMNSNLGLNPANDGKMIRLVLPPLTEERRKDIVKQLKRDAEEAKVALRNIRRDAIDQLKKLEKDKSISEDELKRAEKDVQDSTNSHVAKVDEVLLHKEKEVMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_PLAFA
Sequence: MLSKFYYCKMRKGKSPSSFFSLHKKYLLTGVTILSFIFMFQYKYHEVLTVYEDKTNVQQSSRLFWTRLLFGRTRSRITGRIFNIEIPHSSRLYVYNFFIKYLNINKEEIKYPIESYKSLGDFFSRYIREDTRPIGDLNEYSIVSPCDSEIVDFGELTSNYLDNVKGIKFNIKTFLGSDMIKKYNDDSTSFYYAIFYLSPKKYHHFHAPFNFKYKIRRHISGEVFPVFQGMFKIINNLFDINERVILSGEWKGGHVYYAAISAYNVGNIKIVNDEDLLTNNLRTQLSYMGGDINTKIYDHYKDLEIGDEVGEFKVGSSIIVIFENKKNFKWNVKPNQQISVGERIGGVDQPKQPQNKFIKIRS
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).  Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single- pass membrane protein. Note=Equally found in the membrane-bound as well as in the soluble fraction.
Protein: Y205_ALIFM
Sequence: MIIPWQDIAPDTLENLISEFVLREGTDYGEVEISHQEKVDQIKVLLKNGEAMVVFSELHETVDIQTKARFNPNLTNHNYD
What are the official names of this protein?
UPF0270 protein VFMJ11_0205.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: APT_LEUMM
Sequence: MTVDLHDFVATVEDYPEPGVSFRDISPLMGDGVAYKQAVDAIADFAKHLNVDLIAGPESRGFIVGSPLAYAMNIGFVPARKGGKLPREAVSASYTLEYGGVNELEIHKDAIKPGQRVLIVDDLLATGGTINATREIIEKLGGIVAGVAFIIELESLQGREKIMKAGEVPFLALMEY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_KLEP7
Sequence: MATINQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RS4_PAEAT
Sequence: MANNTRARRTARLSRALGIALTPKAAKYMERRPYGPGEHGRARKKQDSDYAVRLREKQRLRAQYGIREAQMTRAFEEARRTKGLTGENLVELLEMRLDALVLRAGFARTIAQARQLVVHRHIMVDGIRVDRPSFRVGEGQLIHVHSRSEVMPPFQVAAAGAHVLNNVPAYLDVKIDALQARLVRRPKRSEVPVICEEQLVVEFYAR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.