PharMolix/UniProtQA huggingface dataset:
Protein: RL2_HERAR
Sequence: MALVKVKPTSPGRRGMVKVVNADLYKGRPFAGLLEKKSKTAGRNNNGHITTRHIGGGHKQHYRVIDFKRTKDGIPAKVERIEYDPNRTANIALVLYADGERQYIIATKGMAVGDQLMNGSEAPIKSGNCLPIRNIPVGTIMHCVEMLPGKGAQMARTAGAGVVLMAREGVYAQVRLRSGEVRRVHIECRATVGEVGNAEHSLRKIGKAGAMRWRGVRPTVRGVVMNPVDHPHGGGEGKTAAGRHPVSPWGQQTKGKKTRRNKRTTSMIVSRRGKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RS5_VIBCH
Sequence: MAKEQQVQANDLQEKLIAVNRVSKTVKGGRIMSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRSMVTIALNEGTLHHPVKGRHSGSKVYMQPAAEGTGVIAGGAMRAVLEVAGVHNVLSKAYGSTNPINIVRATIDALVDVKSPEMVAAKRGLTVEAISE
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: SYK_BURM1
Sequence: MTEPTQTQPAVAADENQIIAERRDKLRALREQGVAYPNDFRPTHRAAELQAKFAESDKEALEANPFEVAVAGRMMLKRVMGKASFATVQDGSGQIQFFVTPNDVGAETYDAFKKWDLGDIVAARGVLFRTNKGELSVKCTELRLLSKALRPLPDKFHGLSDQEMRYRQRYVDLIVTPETRDTFRARTKTIASIRKFMSDAEFMEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPELYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTEQLIRQAAIDALGTATIQYQGRELDLAKPFHRLTITQAIQKYAPQYTDGQLSDNAYLRSELKRLGVDVTQPAFLNAGIGALQLALFEETAESQLWEPTFIIDYPVEVSPLARASDTVPGITERFELFITGREIANGFSELNDPEDQAARFKKQVEQKDAGDEEAMYFDADYIRALEYGMPPTGGCGIGIDRLVMLLTDSPTIRDVLLFPHLRRED
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_RHOPS
Sequence: MRVIASSIRKGNVLEQDGKLYVVLSAENIHPGKGTPVSQIEMRRISDGVKVSERYKTTDQVEKATIEERNYTFLYEDGEGFHFMEPESFDQVQVTKDVVGNSAPYLAENMVVKLSMHDTTAVAITLPQRATLEVVETEPVTKGQTASSSYKPAILSNGVRTAVPPHVGVGTRVVVLTEDGSYVERAKD
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL331_STAHJ
Sequence: MRVNVTLACTECGDRNYISTKNKRTNPERVEMKKYCSRDNKHTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: SPED_BUCAT
Sequence: MIKLQKLKLYGFNNLTKSLSFCIYDICYANTNDSRNSYISYIDEQYNAIRLTKILKKTCSIIGANVLNIFHQDYEPQGASVTILVCEEPMSMEKIDALNKNIVSSSVLAHLDKSHICVHTYPESHPQSGICTFRADIEVSTCGIISPLNALNYLIHQLESDIVTIEYRVRGFTRDIHGIKHFIDHKINSIQNFMSDDIKSMYDMVDVNVYQENIFHTRMLLREFNLKNYLFNINLENLEKEERSYIMKLLSKEMREIYYGRNISR
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: CNNM4_RAT
Sequence: MAPGGGGGRRDGWPARGRLLLAALLLLLWTRAASGQSSPQQSVILGMRLASCNKSCGMNPDGIIFVSEGSTVNLRLYGHRLGEISSNLISFTEVDDAETVHNSTNCLELTKDLVVQRLVNVSRGNTSGMLVVITKFLRRSENMKLYALCTRTRADGPWLKWTDKDSLLFMVEEHGRFLPLWLHILLVLVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGIMAVASSTIGIVIFGEILPQALCSRHGLAVGANTIVLTKIFMLLTFPLSFPISKLLDFVLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLHDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDTYTDNRTRKRVSMKNKRDFSAFKDADNELKVKISPQLLLAAHRFLATEVPQFSPSLMSEKILLRLLKYPDVIQELRFDEHNKHCTRHYLYTRNKPADCFILILQGKVEVEAGKENMKFETGAFSYYGTMALSLAPPDRSPAHPTPLSRSASLSYPDRNTDMTPSSLAGSNQFGSCILGQYVSDFSVRALTDLQYIKVTRQQYQNGLLASRMDNSPQLTLDGCATCTENLSERPELPVVDETTTLLNERNLLLHRASQEGTI
What is the function of this protein?
Probable metal transporter.  The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions.  May play a role in biomineralization and retinal function.
What are the official names of this protein?
Metal transporter CNNM4, Ancient conserved domain-containing protein 4, Cyclin-M4.
What is the protein family that this protein belongs to?
Belongs to the ACDP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THIK_SALPB
Sequence: MRSNNNNPLTRDEILSRYFPQYRPAVAASQGLSGGSCIIAHDTHRIVLRRHHDPDAPPAHFLRHHRALSQLPASLAPRALFYTPGWMAVEYLHGVVNSALPDADELAALLYHLHQQPRFGWRIALSPLLAQYWSCCDPARRTPFWLRRLKQLQKNGEPRPLRLAPLHMDVHGDNIVLTSAGLRLIDWEYAGDGDIALELAAVWVEDERQHRQLANAYAACARIDARQLWRQIRLWHPWVIMLKAGWFEYRWRQTGEQQFIRLADETWRQLRMKG
What is the function of this protein?
Catalyzes the phosphorylation of thiamine to thiamine phosphate.
What are the official names of this protein?
Thiamine kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine kinase family.
Protein: ACKA_STRA3
Sequence: MSKTIAINAGSSSLKWQLYEMPEEKVVAKGIIERIGLKDSISTVKFDDKKDEQILDIVDHTQAVKILLEDLTKHGIIKDFNEITGVGHRVVAGGEYFKESALVDDKVVEQVEELSALAPLHNPAAAAGIRAFREILPDITSVCVFDTAFHTTMQPHTYLYPIPQKYYTDYKVRKYGAHGTSHQYVAQEAAKQLGRPLEELKLITAHVGNGVSITANYHGQSIDTSMGFTPLAGPMMGTRSGDIDPAIIPYLVANDSELEDAAAVVNMLNKQSGLLGVSGTSSDMRDIEAGLQSKDPNAVLAYNVFIDRIKKFIGQYLAVLNGADAIIFTAGMGENAPLMRQDVIAGLSWFGIELDPEKNVFGYFGDITKPDSKVKVLVIPTDEELMIARDVERLKAK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYC_HUMAN
Sequence: MLKFRTVHGGLRLLGIRRTSTAPAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE
What is the function of this protein?
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.  Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
What are the official names of this protein?
Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: LEUD_OLEA2
Sequence: MQYNGTARKVGDHIDTDAIIPARFLVTTDPAQLGANCMEGLEHGWVSRVQQGDIMVGGKNFGCGSSREHAPIAILGAGMPVVVAHSFARIFYRNGFNMGLILIEIGDDADRIHDGDVLSVDVENGRITNHTTGDVISCPPLPPFMHDILDKGGLVPYVRERLAAGDA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: VATL_VIGRR
Sequence: MASFSGDETAPFFGFLGAAAALVFSCMGAAYGTAKSGVGVASMGVMRPELVMKSIVPVVMAGVLGIYGLIIAVIISTGINPKAKSYYLFDGYAHLSSGLACGLAGLSAGMAIGIVGDAGVRANAQQPKLFVGMILILIFAEALALYGLIVGIILSSRAGQSRAD
What is the function of this protein?
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase.  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
What are the official names of this protein?
V-type proton ATPase 16 kDa proteolipid subunit, V-ATPase 16 kDa proteolipid subunit, Vacuolar proton pump 16 kDa proteolipid subunit.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase proteolipid subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein: BPT_SPHEL
Sequence: MTALSRFPRFFVTSPSPCPYLPGRQERKIFTELSGQQAGELNDALSRIGFRRSQSVAYRPSCAGCTACVSVRVVTEGFQPNATQRKLLKRYGDLEVTACKPWATGEQYELLKRYLDSRHPGGGMAAMDESDYADMVEQSPVSSYVIEYREPSVNGERGRLVGACITDQQGDGLSMIYSYFVTDDEARPGMGNFIIMDHILRARAAGLPYVYLGYWVKGSARMAYKTRYRPIEVLGPTGWALLEDEDMVGAMPSAVAAALA
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHLN_ANTAG
Sequence: MSIQISETLTFECETGNYHTFCPISCVAWLYQKIEDSFFLVIGTKTCGYFLQNALGVMIFAEPRYAMAELEEGDISAQLNDYEELKRLCFQIKKDRNPSVIIWIGTCTTEIIKMDLEGMAPKLEVELGVPIVVARANGLDYAFTQGEDTVLAAMAHRCPERDLLIDENKVIQNQTIQNIFSLFSQKKKEETLKYLELKNHPPLVLFGSLPSTVASQLSLELKRQSIQVSGWLPTQRYTDLPSLGDGVYVCGVNPFLSRTATTLIRRRKCKLIGAPFPIGPDGTRAWIEKISSVFGIKTKGLEEREQQVWQSLKNYLNLVRGKSVFFMGDNLLEISLARFLIRCGMIVYEIGIPYMDKRYQAAELALLRNTCREMCTPMPRIVEKPDNYNQIQRMRELQPDLAITGMAHANPLEARGINTKWSVEFTFAQIHGFTNAKDVLELVTRPLRRNNSLEDLGWTNLIKKDNKIKVI
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PIN1_BOVIN
Sequence: MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSGSGKNGQGEPTRVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
What is the function of this protein?
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs.  By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes.  Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized.  Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity.  Down-regulates kinase activity of BTK.  Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation.  Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.  Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.  Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN.  May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).  Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, Rotamase Pin1.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with NEK6 in the nucleus. Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization.
Protein: MNMC_BURO0
Sequence: MPDRLVSATLALRDDGTLVSPEFGELHRGASGTLARAHRTFVAGNGLPARWQRRRTFTIVTTAFGAGAGFLAAWAAWRDDPARCERLHVVAVEPHPFSRDDLHRAVSHMVADTTISADVDALLDAWPMRVPGLHRLEFDAGRVVLTLAFGDTIDLLKKLVARADAFFLDGAAASSDGIRALAKLAGEHATFATHAKSDDVKHALGETGFTFREVDDRLVGDYAPRWRARRHEPPRALPVTTRRAIVIGAGLAGCAVVERLAARGWDVTLIERHERIASEASGNPAGVFHPLMTRDDNVASRLTRGGFLHALARWRALERAGHAFSRSTHGMLHLAESADDFARMRDAFDAFGAPSDYATLLDADAARAHLNLPVAQGGLLFPHGGAVWPAGLCAAQYAAAGERVRLLASTCVARLERRDDTWHALDDTGATLADAPVVVLANAGDAARLAGLRHVALQPVRGQLTLLPPGTTAPLPCPAIGDGYAVPLDDGTLLIGATFEPDDTDPAMRAAGHAENLDRVRHLLPGLIGALPDPATLRGRVAFRWVVGDRLPLIGPLADETQATANARALGGAQARDLPRMPGLYGAFGFGSRGLVWAALGAELIASQLEGEPWPLERELADAVDPARFLIRALRARRVGSAG
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
Protein: GPX3_SAPAP
Sequence: MARLLQASCLLSLLLAGFLPQSRGQDKSKMDCHGGVSGTIYEYGALTIDGEEYTPFKQYIGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLDLLGFPCNQFGKQEPGENSEILPSLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPVMRWHHRTTISNVKMDILSYMRRQAALGVKRK
What is the function of this protein?
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
What are the official names of this protein?
Glutathione peroxidase 3, GPx-3, GSHPx-3, Plasma glutathione peroxidase, GPx-P, GSHPx-P.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLAB_BACTN
Sequence: MRTFLSLKTCLLSALLLCVNSIAASKIISVSDFGLKPDSRINAVPFIQKAIDACKQHPGSTLVFPKGRYDFWAQHAIEKDYYETNTYDVNPKILAVLLEQINDLTIDGNGSEFIMHGRMQPFTLDHCRNITLKNFSVDWEIPLTAQGIVTQSTSEYLEIEIDSHQYPYIIENKRLTFVGEGWKSSLWAIMQFDPDTHLVLPNTGDNLGWRSYDATEINPGLIRLSDPKKEADKFFPAPGTVLVLRHSTRDHAGIFIYHSMDTKLENVKLFHTCGLGILSQYSKNISFNDVHIIPNTSKKRVLSGHDDGFHFMGCSGLLKIENCSWAGLMDDPINIHGTCSRIMEVLSPTRIKCKFMQDMSEGMEWGRPDETIGFIEHKTMRTVATGKMNKFEALNKAEFIIELSVPLPAGVEAGYVIENLTCTPDAEIRNCHFGSCRARGLLVSTPGKVIIENNVFESSGSAILIAGDANAWYESGAVKDVLIRNNDFRYPCNSSIYQFCEAVISIDPEIPTPEQKYPYHRNIRIMDNTFHLFDYPILFARSVNGLTFSSNTLIRDTTYQPYHYRKEGITLEACKSVVISNNKIEGDVLGRIVTIEKMKPSDVKISKNPFFKLKK
What is the function of this protein?
Alpha-galactosidase.  Removes both branched alpha-1,3-linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures.
What are the official names of this protein?
Alpha-1,3-galactosidase B, BtGal110B, Exo-alpha-galactosidase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 110 family. B subfamily.
Protein: LYSCN_BOVIN
Sequence: MKALLILGLLLFSVAVQGKVFERCELARSLKRFGMDNFRGISLANWMCLARWESNYNTQATNYNAGDQSTDYGIFQINSHWWCNDGKTPGAVNACHLPCGALLQDDITQAVACAKRVVSDPQGIRAWVAWRSHCQNQDLTSYIQGCGV
What is the function of this protein?
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
What are the official names of this protein?
Lysozyme C, non-stomach isozyme, 1,4-beta-N-acetylmuramidase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
Protein: SEC1_DICDI
Sequence: MATSLRELCKDRILNEMVRTITPEASNGWKALIVDQDSLRVISACCGMFDIMEEKVTVVEKIDNPRQRLPNLEAIYFLTPTAQSIDLLINDFKKKSSPHYLAIHLFLTSKLPEVEFKKLSASLAVHRIKTFKEINLEFLAIESQAFHLDQNNTLFQLFSPDSIDPTEEQAKIATRLVSLCVSLNECPIIRFSRSHPVSAMIAGFTQEKLDNVMRTVKSFKPNDDRSTLLILDRTQDPLAPLIHEFSYQAMVYDLFDIENDKFSFDTVTNAGATLKKDVLLGETDYMWSGLRHQHIADVSTNLTTRLDEFLKTNQVSQYGQHTGSLKEAGEVVRSLPQYQEMMGKYSVHINLADRASAKFPELEQLAYLEQDLATGEDANGNSPKNVTGRLSNYLSDFSAEKYNKIRLLMMYIISQDGIKEEDRRRLMEMAGISQSEQNAFTNLRYLGVTLMKGAKGKKPISPPKNRKSESGNVPYEVSRYVPVVKDIAENIINETLPSTDFPFVKEEPIARATNAPVSKVSLKGKSKQPRWADPNVQVEETKYSGSKLIIFVIGGMTFSEMRSIYELSSHYKKNIYIGSTNILLPKKYIDQLLTLKNE
What is the function of this protein?
Involved in the vesicle trafficking.  Binds syntaxins (By similarity).
What are the official names of this protein?
Protein transport protein sec1.
What is the protein family that this protein belongs to?
Belongs to the STXBP/unc-18/SEC1 family.
Protein: COX2_DROSI
Sequence: MSTWANLGLQDSASPLMEQLIFFHDHALLILVMITVLVGYLMFMLFFNNYVNRFLLHGQLIEMIWTILPAIILLFIALPSLRLLYLLDEINEPSVTLKSIGHQWYWSYEYSDFNNIEFDSYMIPTNELTTDGFRLLDVDNRVILPMNSQIRILVTAADVIHSWTVPALGVKVDGTPGRLNQTNFFINRPGLFYGQCSEICGANHSFMPIVIESVPVNHFIKWISSNNS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FIBIN_BOVIN
Sequence: MVFLKFLWMGFLCHLCQGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDHRRCSQGEGSSASTLLSLTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKETLDISVGLRDKYELLALTIRSHGTRLGRLKNDYLKV
What are the official names of this protein?
Fin bud initiation factor homolog.
What is the protein family that this protein belongs to?
Belongs to the FIBIN family.
What are the subcellular locations of this protein?
Secreted. Golgi apparatus. Endoplasmic reticulum.
Protein: THIC1_SACS2
Sequence: MAIIEEARSGQITDEMKEISKLEGIPVEKVRNRISECKIILIRNAKYPSKKLVPIGKGLTTKVNINIGTSDEVVNLQMELEKVKVANRWGDTLMDLSTGGDLDDIRREIIRASELPVGTVPVYQVFIESFKKKSGGAYFTEDELLSTVEKHLKDGVAFMTIHAGITKELAIRALKSNRIIPIVSRGGDMIAGWMIHNNSENPYRKHWGYLLEMFKEYDAVISLGDALRPGATGDAHDEFQVGELLETARLVKSALKEGVQVMVEGPGHVPLNEIAWDVKLMKKLTGGVPYYVLGPLPIDVGAPYDHIASAIGAAISSAAGADLLCYLTPAEHLGLPTVKQVEEGAIAYRIAAHAGDVVKLGRRVRKWDDEVSYYRGKLEWDNMISRLIDPQRAYQVYTQFGIPKVKACTMCGGYCPMMWAMDQVRKIGSSSSL
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase 1, Hydroxymethylpyrimidine phosphate synthase 1, HMP-P synthase 1, HMP-phosphate synthase 1, HMPP synthase 1, Thiamine biosynthesis protein ThiC 1.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: U512J_DICDI
Sequence: MAIFKSISNSTGSMGSSIGFSSKDGFSSNDNSISCFDGGGGGGGLGGWGGIGGFNVGCGGSNANIINIDIDIGRRHRRCC
What are the official names of this protein?
UPF0512 protein J.
What is the protein family that this protein belongs to?
Belongs to the UPF0512 family.
Protein: UFE1_YEAST
Sequence: MMSDLTPIFRKYVAVIDDARNEQNGIDDHVERKQEDFGNSNETCEMFRDSFIKECARLLKFLVELNKVIKQIEKNYLDDFNMSDAEKDEFDMECRLQIQQYFKKFEFLENYEMERHNLSLKRFQSKSHRWSKILSNKNDNTKHVIHPQDIENGVYEFRLGVLRCLNLWIKYVSSKFTTIQQERLILENKMNFNSTPMPTLSNNADDFSADAIDISVSQSAPVETVQDEVKHYEETISKLTQEQLQVLETEHSELLNQKNEQLKKVETINKTILDIVNIQNELSNHLTVQSQNINLMLNNQDDIELNIKKGNKELRKAKRAAGRTAKMTTYGAIIMGVFILFLDYVG
What is the function of this protein?
Syntaxin required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
What are the official names of this protein?
Syntaxin UFE1.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Protein: PURA_SALPB
Sequence: MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVTSIIGNGVVLSPSALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEYGATTGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPLAADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRTETMILRDPFDA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.