PharMolix/UniProtQA huggingface dataset:
Protein: E75_METEN
Sequence: MFCDQDMYEIPADCQVLVDKTVIEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKAKILAAMQSVNAKSQERAVLAELEDDTRVTAAIIRAHMDTCDFTRDKVAPMLQQARTHPSYTQCPPYLACPLNPRPVPLHGQQELVQDFSEALLPAIRGVVEFAKRLPGFQQLPQEDQVTLLKAGVFEVLLVRLAGMFDARTNAMLCLNGQLVRREALHTSVNARFLMDSMFDFAERVNSLALNDAELALFCAVVVLAPDRPGLRNAELVERVHRRLVNCLQAVVSKHHPENPNLQRDLLSKIPDLRTLNTLHSEKLLKYKMTEHTAAGAPWDDSRSSWSMEQESSVGSPSSSYTTDEAMRSPVSCSESICSGESASSGESLCGSEVSGYTELRPPFPLARRRHDHSEGASSGDEATESPLKCPFSKRKSDSPDDSGIESGTDRSDKLSSPSVCSSPRSSIDEKERGGPARTICRCCARLQRRPSSTRICSWRKPTTSPIKSSVRNVGKRSLTPHSPPPPRSWSRRCLSLHSTRALWLRHTPPWPPVWRRPLA
What are the official names of this protein?
Nuclear hormone receptor E75, Nuclear receptor subfamily 1 group D member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: 14331_SCHMA
Sequence: MTTSWVLQSKDLSNTDLVHIAKLAEQAERYDDMAAAMKRYTEASGNLGNEERNLLSVAYKNVVGARRSAWRVIHGSEMKAVNDRTKKQIAEEYRIKMEKELNTICNQVLALLEDYLLPNASPDDSKVFFLKMQGDYYRYLAEVATDDARTEVVQKSLDAYTKATTAAENLPTTHPIRLGLALNFSVFFYEIQNDAAKACELAKSAFDSAIAELDQLQDDSYKDSTLIMQLLRDNLTLWASDQTAEGDVENDS
What are the official names of this protein?
14-3-3 protein homolog 1.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: DNRD_STRS5
Sequence: MSPQIDLVRRMVEAYNTGKTDDVAEFILHEYLNPGALEHNPELRGPEAFAAAVTWLKYAFSEEAHLEEIGYEENGPWVRAKLALYGRHVGNLVGMPATGRRFSGEQIHLIRIVDGKIRDHRDWPDYLGTYRQLGEPWPTPEGWRPCPPPPRRRHDRSTDTP
What is the function of this protein?
Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin).  These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers.  Catalyzes the cyclization of aklanonic acid methyl ester to yield aklaviketone.
What are the official names of this protein?
Aklanonic acid methyl ester cyclase DauD, AAME cyclase, Methyl aklanonate cyclase.
What is the protein family that this protein belongs to?
Belongs to the polyketide cyclase DnrD family.
Protein: AROE_VIBCM
Sequence: MASQIDQYAVFGNPINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEGAL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: MLTC_ECO8A
Sequence: MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIAGPKDYVKYTDQYQTRSHINFDDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLKNRLQSRNNGLRIIYSVTINMVPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: SYAP1_MOUSE
Sequence: MFGGLSSWLGLKPPEGAAAEGEEPPSRDGDKLSAGAAPSEESPERPVEPTEEQQQQPPTEDPQFLHQAKGLGNYLYNFASAATKKITESVTETAQTIKKSVEEGKIDDILDKTILGDFQKEQKKFVEEQNTKKSEAAVPPWVESHDEETIQQQILALSADKRNFLRDPPAGVQFNFDFDQMYPVALVMLQEDELLSKMRFALVPKLVKEEVFWRNYFYRISLIKQSAQLTALAAQQQASGKEEKSSNRDDNLPLTEAVRPKTPPVVIKSQLKSQEDEEEISTSPGVSEFVSDAFDTCSLNQEDLRKEMEQLVLDKKQEEATALEEDSTDWEKELQQELQEYEVVAESEKRDENWDKEIEKMLQES
What is the function of this protein?
Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339).
What are the official names of this protein?
Synapse-associated protein 1, BSD domain-containing signal transducer and Akt interactor protein, BSTA.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Golgi apparatus. Perikaryon. Cell projection, axon. Cell projection, dendrite. Cell projection, growth cone. Presynaptic cell membrane. Postsynaptic cell membrane. Membrane. Note=Localizes to cholinergic neuromuscular junctions and in actin-rich growth cone regions (PubMed:27344443). Membrane-associated in a epidermal growth factor (EGF)-dependent manner (By similarity).
Protein: FLA_STRCT
Sequence: MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR
What is the function of this protein?
Involved in the biosynthesis of fluorometabolites.  Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine.  It can also use 2'-deoxyadenosine in place of adenosine as substrate.
What are the official names of this protein?
5'-fluoro-5'-deoxy-adenosine synthase, 5'-FDAS, 5'-fluorodeoxyadenosine synthase, Fluorinase.
What is the protein family that this protein belongs to?
Belongs to the SAM hydrolase / SAM-dependent halogenase family.
Protein: NIKR_DESDA
Sequence: MGNLARFGVSLDQDLLEPFDELCRRKSYPNRSEAIRDLIRKALVEEKWNSDAHGAGTLTLVYDHHKNDLSRRLVQIQHDDHDLIVTTLHVHLDHYNCLEVLVLKGEPKRMRALADKLIACRGVKHGTFTGTTTGEDLA
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: MCM3_HUMAN
Sequence: MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232).  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425).  Required for the entry in S phase and for cell division (Probable).
What are the official names of this protein?
DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: RLMN_MYCBO
Sequence: MVPELMFDEPRPGRPPRHLADLDAAGRASAVAELGLPAFRAKQLAHQYYGRLIADPRQMTDLPAAVRDRIAGAMFPNLLTASADITCDAGQTRKTLWRAVDGTMFESVLMRYPRRNTVCISSQAGCGMACPFCATGQGGLTRNLSTAEILEQVRAGAAALRDDFGDRLSNVVFMGMGEPLANYARVLAAVQRITARPPSGFGISARAVTVSTVGLAPAIRNLADARLGVTLALSLHAPDDGLRDTLVPVNNRWRISEALDAARYYANVTGRRVSIEYALIRDVNDQPWRADLLGKRLHRVLGPLAHVNLIPLNPTPGSDWDASPKPVEREFVKRVRAKGVSCTVRDTRGREISAACGQLAAVGG
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1821_PELTS
Sequence: MLFLKEEKDGVLLKVRVQPRAARNQVAGLYEDALKIRLTAPPVDGEANEACRAFLADSLSLPPSKVEIVSGHASRTKVVKIAGVGAEKVRRAFGL
What are the official names of this protein?
UPF0235 protein PTH_1821.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: V16K_TRVPS
Sequence: MTCVLKGCVNEVTVLGHETCSIGHANKLRKQVADMVGVTRRCAENNCGWFVCIIINDFTFDVYNCCGRSHLEKCRKRVEARNREIWKQIRRIQAESSSATRKKSHNSKNSKKKFKEDREFGAPKRFLRDDVPLGIDQLFVF
What are the official names of this protein?
16 kDa protein.
Protein: HDHA_BACFN
Sequence: MNRFENKIIIITGAAGGIGASTTRRIVSEGGKVVIADYSREKADQFAAELSNSGADVRPVYFSATELKSCKELITFTMKEYGQIDVLVNNVGGTNPRRDTNIETLDMDYFDEAFHLNLSCTMYLSQLVIPIMSTQGGGNIVNVASISGITADSNGTLYGASKAGVINLTKYIATQTGKKNIRCNAVAPGLILTPAALNNLNEEVRKIFLGQCATPYLGEPQDVAATIAFLASEDARYITGQTIVVDGGLTIHNPTINLV
What is the function of this protein?
7alpha-hydroxysteroid dehydrogenase involved in the metabolism of bile acids in the gut.  Catalyzes the NAD(+)-dependent oxidation of the 7alpha-hydroxy group of 7alpha-hydroxysteroids, such as cholate, chenodeoxycholate, taurochenodeoxycholate, glycochenodeoxycholate, taurocholate and glycocholate, to the corresponding 7-oxosteroids (PubMed:14756531).  Since it is also able to catalyze the reduction of nonsteroidal carbonyl compounds such as various benzaldehyde analogs to their corresponding benzyl alcohols, this enzyme may also function in the detoxification of xenobiotics containing carbonyl groups in the large intestine (PubMed:21600233).
What are the official names of this protein?
7alpha-hydroxysteroid dehydrogenase, 7alpha-HSDH, Aromatic aldehyde reductase, NAD-dependent 7alpha-hydroxysteroid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MAP2_MALGO
Sequence: MPATAEAADAATQATDAFSTKLEENKLPEGQERGPEEEEDDDDDETPAPGDAEKKKKKKKKSGAKKKKSKTAKAVMEQTEPPSIGLTKMFPNGVFPVGEVQQYDETKFDESRKRVTGEELRERERLIQEKDGFNYNFIRRAAEVHRQVRQYAQRTIKPGMSMTEIANMIEDGTRALVEVNGFESGIGFPTGLSLNEVAAHYTPNAGDKRILQSGDVLKVDFGVQVKGRIVDSAFTMNFEPTYDPLLAAVRAATNTGVKEAGIDARLGEVGAAIQEVMESHEFEAEGKTHQVKCIRNLQGHDIAPYRIHGGKSVPIVAVPNLDVKMEEGETFAIETFGSTGRGYVVDSGECSHYARQANPPHVSLRINSARQLLYTINKNFGSLPFCRRYLDRLGEQNYLLGLRHLVSQGVVQDYPPLADVPGCMTAQFEHTILLRPTCKEVVSRGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2, MAP 2, MetAP 2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XANE_ASPFU
Sequence: MSTQHGPKSTRTNDLYELAVNISSTVEAFVGRLDAIGAERPNLDNPFPEIIQDEGAQLARLKILRLCERLMALVQGPVQWLMFQNMAFLDAACVGAILDMGIHDIIAPGPEPTSLDQIVEATGASKDILKRIMRVCTQRLVFDEIAPEQFIHNGVSLQFLAPPVQALISHACDDGLRMAAHFTDSLKKTDWKGSDDPENTAFSLAFNTNKGLFDYFYTEDLARGQRFALGMAGSEIMKTLTEDMFPFESLPQGAKVVDVGGGRGHVSVRIAEKVPGLNFVVQDDESMLEAGQAEGVPKAVKDRIEFMPHDFFNEQPVKGADVYLLRFILHDHSDSRCAKILSNIVDAMEPGKSRILIDDAIVPSFLGPESSRFFNLLDLYMLAGLNGKERTLEQWNYLIQMVSPKLVLEKVWKTPNGGPESGTILELRLQE
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the isocyanide xanthocillin and its derivatives (PubMed:29844112).  The first step of the pathway consists in the conversion of tyrosine into a vinyl-isonitrile intermediate by the isocyanide synthase xanB (PubMed:29844112).  Subsequent oxidative dimerization of this intermediate to form xanthocillin may involve the cytochrome P450 monooxygenase xanG, whose expression is coregulated with that of XanB (PubMed:29844112).  Xanthocillin can be further modified by the isonitrile hydratase-like protein xanA which introduces N-formyl groups and the methyltransferase xanE which introduces methyl groups, leading to the production of several derivatives including fumiformamide (PubMed:29844112).  Finally, fumiformamide can be subject to both oxidative and reductive cyclization to yield melanocins E and F, respectively (PubMed:29844112).
What are the official names of this protein?
O-methyltransferase xanE, Xanthocillin biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: GTRA_ECOLI
Sequence: MLKLFAKYTSIGVLNTLIHWVVFGVCIYVAHTNQALANFAGFVVAVSFSFFANAKFTFKASTTTMRYMLYVGFMGTLSATVGWAADRCALPPMITLVTFSAISLVCGFVYSKFIVFRDAK
What is the function of this protein?
Involved in O antigen modification.  Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity).
What are the official names of this protein?
Prophage bactoprenol-linked glucose translocase homolog, Bactoprenol-linked glucose translocase homolog from prophage CPS-53.
What is the protein family that this protein belongs to?
Belongs to the GtrA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NRAM_INBYB
Sequence: MLPSTIQTLTLFLTSGGVLLSLYVSASLSYLLYSDILLKFSPTEITAPKVPLDCANASNVQAVNRSATKGMTLLLSEPEWTYPRLSCQGSTFQKALLISPHRFGESRGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMGMELYVKYDGDPWTDSDALAPSGVMVSMKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: TRPC_BORA1
Sequence: MNDILAKILAVKAEEVATARQMRSEAELLREAQARQDVRGFAQAIEDKIAQGKPGVIAEIKKASPSKGVLRENFDASEIAASYAAHGAACLSVLTDVQFFQGSHDNLRRARAACPLPVLRKDFILDPYQIISARAMGADCVLLIVAALSPTQLRDLEAVAMDLGMDVLVEVHDEAELDVALGMKTPLLGINNRNLRSFETRLETTLNLLPRIPAGKRVVTESGILQPDDVQLMRRHGVQAFLVGEAFMRAEEPGAELARLVA
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: SYP_THISH
Sequence: MRATRFPLATLKETPADAEVISHQLMLRAGMIRRLASGLYSWTPLGLRVLRKVEGLVRDEMDRAGALELLMPAVQPAELWQESGRWEQYGPELLRLKDRHMREFCFGPTHEEVITDYVRREVKSYRQLPVNYYQIQTKFRDEIRPRFGVMRAREFLMKDAYSFHVDEDSLKETYARMHEAYTRIFTRCGLDFRAVLADTGSIGGNASHEFHVLADSGEDAIAFSDVSDYAANVELAEAVAPATERAAPGEAMRLVDTPNARTIADLVEQHGLAIEKTVKTLVVAAAEGAEAPLIALLVRGDHELNAIKAEKLPQVASPLRMATEEEIRAAIGAGPGSLGPVNLPIPCVVDRAVALMSDFGAGANIDGKHYFGINWERDLALPPVADLRNVVAGDPSPDGQGSLQIRRGIEVGHIFQLGRKYSEAMGATVLDEQGRSLVVTMGCYGIGVSRVVAAAIEQNHDAQGIIWPEALAPFTVALCPINAQKSQRLREAADALYERLLNAGFEVFYDDRGLRPGAMFADMELIGIPHRLVLGERGLDAGEIEYKGRRDTDTTQVALDGVLDFLRQRMNAAH
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISA_BRUA2
Sequence: MFTGIITDIGKVDRVKPLNEGVLLRIETAYDPETIELGASIACSGVCLTVVALPEKGSNARWFEVEAWEEALRLTTISSWQSGRKINLERSLKLGDEMGGHLVFGHVDGQAEIVERKDEGDAVRFTLRAPEELAPFIAQKGSVALDGTSLTVNGVNANEFDVLLIRHSLEVTTWGERKAGDKVNIEIDQLARYAARLAQYQK
What is the function of this protein?
Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
What are the official names of this protein?
Riboflavin synthase, RS.
Protein: ZAPB_KLEP3
Sequence: MTMSLEVFEKLESKVQQAIDTITLLQMEIEELKEKNNTLVQEVQSAQHGREELERENSQLKEQQQGWQDRLQALLGRMEEV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid-cell, in a FtsZ-like pattern.
Protein: MNMG_LEGPH
Sequence: MNLEQLYDVIVVGGGHAGTEAALAAARLGVKTLLLTHNIDLLGQMSCNPAIGGIGKGHLVKEIDALDGAMAKAADQAGIQFRILNASKGPAVRATRAQADRVLYRKAIRTQLQSQANLTIFQQAVDDLKIEGGLVTGVVTQMGLTLKARAVVLTVGTFLGGKIHVGMNQYAGGRAGDPPSIALSKSLRDLDLPVGRLKTGTPPRIDRRTIDFSQMVEQPGDTPVPVFSYLGAASDHPQQVPCHITHTTEATHDIIRNNLDKSPMYAGVIEGVGPRYCPSIEDKIVRFADKTSHQIFVEPEGLTTEEIYPNGISTSLPFEVQVQFVRTIKGFENAHITRPGYAIEYDYFDPRGLTSFLQTKAIPNLFFAGQINGTTGYEEAAAQGIIAGMNAALQIKDQELWCPRRDEAYIGVLIDDLITCGTQEPYRMFTSRAEYRLLLREDNADLRLTEKGRQLGLVGDERWDSFSKKREAIESTQALLYNSWVRVHHNDLFKETLFNPMQHDCRAVEFLKRPEINYQHLLMMDDLNLPELPQEITEQIEIQNKYAGYIDRQQQEIEKLRKHENTLLPETLDYNDVVGLSSEVIQKLNRIKPTSLAQAGRISGVTPAALSLLLVHLKKSRLPV
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_PRIM3
Sequence: MSKKPVALIILDGFALRDEDKGNAVTHAKKPNFDRFWNEYPHATLQASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFEQNETLLAAVKHAKEKGTNLHLFGLLSDGGVHSHIEHLYALLRLAKSEGLEKVYIHGFLDGRDVAPQSAETYLKELNEKIEEYGVGEIATLSGRYYSMDRDKRWERVEKSYRAMVYGEGPSYTSAEECVKDSYENGIYDEFVLPSVITKEDGSPVATIQDEDAVIFYNFRPDRAIQISNTFANEDFRSFDRGEKHPKNLHFVCLTHFSETVDGYVAFKPNNLDNTLGEVLSQNNLKQLRIAETEKYPHVTFFMSGGREAEFPGETRILIDSPKVATYDLKPEMSAYEVTDALLAEIEGDKQDAILLNFANPDMVGHSGMLEPTVKAIETVDECLGKIVDAILAKGGTAIITADHGNADEVITLEGNPMTAHTTNPVPVIVTKQGLELREDGILGDLAPTMLTLLDVAQPKEMTGKTLIK
What is the function of this protein?
Essential for rapid growth and for sporulation.  Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: EFG_BACTN
Sequence: MAKTDLHLTRNIGIMAHIDAGKTTTSERILFYTGLTHKIGEVHDGAATMDWMEQEQERGITITSAATTTRWKYAGDTYKINLIDTPGHVDFTAEVERSLRILDGAVAAYCAVGGVEPQSETVWRQADKYNVPRIAYVNKMDRSGADFFEVVRQMKAVLGANPCPIVVPIGAEETFKGLVDLIKMKAIYWHDETMGADYTVEEIPADLVDEANEWRDKMLEKVAEFDDALMEKYFDDPSTITEEEVLRALRNATVQMAVVPMLCGSSFKNKGVQTLLDYVCAFLPSPLDTENVIGTNPNTGAEEDRKPSDDEKTSALAFKIATDPYVGRLTFFRVYSGKIEAGSYIYNSRSGKKERVSRLFQMHSNKQNPVEVIGAGDIGAGVGFKDIHTGDTLCDETAPIVLESMDFPEPVIGIAVEPKTQKDMDKLSNGLAKLAEEDPTFTVKTDEQTGQTVISGMGELHLDIIIDRLKREFKVECNQGKPQVNYKEAITKTVDLREVYKKQSGGRGKFADIIVKIGPVDEDFKEGGLQFIDEVKGGNIPKEFIPSVQKGFTSAMKNGVLAGYPLDSMKVTLIDGSFHPVDSDQLSFEICAIQAYKNACAKAGPVLMEPIMKLEVVTPEENMGDVIGDLNKRRGQVEGMESSRSGARIVKAMVPLAEMFGYVTALRTITSGRATSSMVYSHHAQVSNSIAKAVLEEVKGRADLL
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.