PharMolix/UniProtQA huggingface dataset:
Protein: SL2C1_VIPAA
Sequence: DFDCPPDWSAYDXQCYYAF
What is the function of this protein?
Regulatory subunit of the blood coagulation factor X-activating enzyme.  Activates coagulation factor X (F10) in a calcium-dependent manner by cleaving the Arg-Ile bond at position 234.  Weakly hydrolyzes insulin B chain, fibrinogen and some components of the extracellular matrix in vitro, but does not activate prothrombin or plasminogen.
What are the official names of this protein?
Snaclec factor X-activator 2 light chain 1, VAFXA-I LC1.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: IHFA_PSEA6
Sequence: MALTKAEMAEHLFEKLGMNKRDAKDLVEAFFEEVREALESGEQVKLSGFGNFDLRQKSERPGRNPKTGEDIPIKARRVVTFRPGQKLKSRVENTKPTE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PNCB_SINMW
Sequence: MPKTDIARRVYNHTWKLDPIIRSLLDTDFYKLLMLQMIWQLYPDVDATFSLINRTKTVRLADEIDEQELRDQLDHARGLRFTKKEMIWLAGNSFYGRKQIFAPEFLVWLAKFRLPPYELSRRDGQFELTFRGRWAETTMWEIPALAIINELRSRAAMKGLGPFTLDVLYARAKARMWLKVEQLREHPNLRISDFGTRRRHSFLWQRWCVEALKEGIGPSFTGSSNVLLAMDNDLEAVGTNAHELPMVAAALARNDRELAAAPYKVLQDWNQLYGGNLLIVLPDAFGTAAFLRDAPDWVADWTGFRPDSAPPIEGGEKIIAWWKKMGRDPREKLLIFSDGLDVDTIVKTYCHFEGRVRMSFGWGTNLTNDFAGCAPTEINGLNPISVVCKVSEANGHPAVKLSDNPRKATGDPGEVERYLRFFGSEDFVEQSVRV
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: CAPSD_AMVMA
Sequence: MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGVRFLYSFLKDFAGPRILEEDLIYRMVFSITPSYAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSYRFNEVWVERKAFPRAGPLRSLITVGLLDEADDLDRH
What is the function of this protein?
Capsid protein.  Binds to the to the 3' end of the nonpolyadenylated viral RNA and is involved in viral RNA translation initiation.  Probably binds RNA and plays a role in packaging (By similarity).
What are the official names of this protein?
Capsid protein, CP, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the alphamovirus/ilarvirus capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: LKHA4_CAVPO
Sequence: MPEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPADPSRKIYKFSQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVDKSAYEFSETESMLKIAEDLGGPYVWGQYDRLVLPPSFSYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHTWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGETQAFTKLVVDLTDTDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSITTDDWKNFLFSHFKDKVDILNQVDWDAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVTAMLVGKDLKVE
What is the function of this protein?
Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities.  Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4).  Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides.  In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL).  Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions.
What are the official names of this protein?
Leukotriene A-4 hydrolase, LTA-4 hydrolase, Leukotriene A(4) hydrolase, Tripeptide aminopeptidase LTA4H.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_SYNC1
Sequence: MSRSATIDRQTQETQINLDLTLDGCGEACIATPVPFMNHMLTLLSRHGFFDLTVKAEGDVEVDDHHTVEDLGICLGQAFVKALGDKQGIRRYGAATVPMDETLASVHIDFSGRSCLVFNMDLPKAKVGSFDVELVEEFFTAFCNHAGANVHVNLVYGRNLHHMIEGVFKAFGRALDEATGLDPRIQGVLSTKGKL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR20_SPIOL
Sequence: MAAISMACVSSQCLSISSKLHNLSFSSTQFPNSSLKPLTFSANLSQPLFSQGCSSLGSFQRRGFSVVCEVATLKKADSAAKRTRQAETRRLRNKARKSEVKTRMRKVFEALDALKKKSGASTEELVPIDNLIAEAYSAIDKAVVKGTLHRNTAARRKSRLARNKKVVEIHHGWYTPSLAPTNV
What is the function of this protein?
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
What are the official names of this protein?
30S ribosomal protein S20, chloroplastic, Chloroplastic small ribosomal subunit protein bS20c.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RRF_HELPH
Sequence: MLQAIYNETKDLMQKSVQALNRDFSTLRSAKVSVNILDHIKVDYYGTPTALNQVGSVMSLDATTLQISPWEKNLLKEIERSIQEANIGVNPNNDGETIKLFFPPMTTEQRKLIAKDAKAMGEKAKVAVRNIRQDANNKVKKLEKDKEISEDESKKAQEQIQKITDEAIKKIDESVKNKEDAILKV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUTI_DIDRA
Sequence: MKFFAFSMLIGEASPIVLALRRTTLEVRQLDPIIRSELEQGSSSSCPKAILIFARGSTEIGNMGVSAGPAVASALEAYGADQIWVQGVGGPYTADLPSNFLPGGTSQSAINEAVRLFNEANTKCPSTPIVAGGYSQGTAVMAGAIPKLDAVRARVVGTVLFGYTQNQQNNKGIKDYPQEDLQVYCEVGDLVCDGTLIITVSHFLYLEEAAGPAPEFLKSKIGA
What is the function of this protein?
Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (By similarity).  Degrades cutin, a macromolecule that forms the structure of the plant cuticle (By similarity).  Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of fungal infection (By similarity).
What are the official names of this protein?
Cutinase, Cutin hydrolase.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENO_CAMC1
Sequence: MVFIEDVEAHEVLDSRGNPTVRATVRLSDGTEASAIVPSGASTGKREALELRDKDDRYAGKGVLKAVSNVNEKIAEAVIGLDAYNQKAVDAEMLELDGTHNYSNLGANAVLGVSMAVARAAAKSLNIPLYRYLGGANASILPVPMFNIINGGAHANNSVDFQEFMIMPFGFSTFSEALRAATEIYHKLKSILNAAGHSTAVGDEGGFAPNLKDNEEPLKLISQAVKEAGYELGSQIKLALDVASSELYKDGKYELEGKKFSSAELISYYEKLCEKYPIFSIEDGLSEDDWSGWAELTKRLGSKVQLVGDDLFVTNEKILREGIEKNIANAILIKPNQIGSVTQTMQTVRLAQRNGYRCIMSHRSGESEDAFIADFAVALNTGEIKTGATSRSERNAKYNRLLEIELEAGEFLGDNI
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: DNLJ_PHEZH
Sequence: MKSVESLTEAEAAEELTRLADEIAAHDIRYYREDAPTISDAAYDALRRRNDELEAAFPHLIRENSPSLRIGAARAEQFAPVEHGVPMLSLDNAFSDADALEFDARVKRFLRLDEEVAYTAEPKIDGLSCSIRYENGRLVRAATRGDGRVGEDVTANVRTIGEIPQKLHGQAWPEVIEIRGEVYLGHAEFAALNEAAASAGQKTYANPRNAAAGSLRQIDPKITAQRPLRFFAYAWGFVSAPFAQTQWEALQALKAWGFRTTPQSRCVKGAEGLMEAYREMEAERPHLGFDIDGVVYKVDRLEWQQRLGFVSRAPRWGIARKFPAEQARTVLEAIDIQVGRTGALTPVARLTPVTVGGVVVTNATLHNADEIARLDVRVGDTVVLQRAGDVIPQILRVIPEERPKDSVPYDFPHVCPCPLRTEVVRETTASGAETVVRRCSGEFACPFQRINHLLHFVSRRAFDIEGLGEKQLTAFFERGWIKAPADIFRLHEKRDELLAMERMGETSVGNLLANIEARRTIGLDRFIYGLGIRHIGETTATVMARGYGTAAHFLEAMDKVAARDPEAVEELDALDQIGGAVIEAAAAFFGEDHNRAMVEDLAGQLTILDAEKPKTDTAVAGKTVVFTGALERMTRDEAKAQAERLGAKVSGSVSKKTDIVVAGPGAGSKLKTAAELGIQVLTEDEWLEMVGS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: THII_STAAW
Sequence: MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTIEAMSAAAIKFAQQFEENSTFKIDVKRADKNFSMDTYELQRELGGAILKHFDNISVNVKRPDHEIRVEVRLDAIYMYEEVVPGSGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGALAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFDKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_ACIB5
Sequence: MAKIIGIDLGTTNSCVAVLEGDKVKVIENAEGARTTPSIIAYKDGEILVGQSAKRQAVTNPKNTLFAIKRLIGRRYEDQAVQKDIGLVPYKIIKADNGDAWVEVNDKKLAPQQISAEILKKMKKTAEDYLGETVTEAVITVPAYFNDAQRQATKDAGKIAGLDVKRIINEPTAAALAFGMDKKEGDRKVAVYDLGGGTFDVSIIEIADLDGDQQIEVLSTNGDTFLGGEDFDNALIEYLVEEFKKEQNVNLKNDPLALQRLKEAAEKAKIELSSSNATEINLPYITADATGPKHLVINVTRAKLEGLVADLVARTIEPCKIALKDAGLSTSDISDVILVGGQSRMPLVQQKVQEFFGREPRKDVNPDEAVAIGAAIQGAVLSGDKNDVLLLDVTPLTLGIETMGGVLTPIIEKNTTIPAKKSQVFSTAADNQPAVDISVYQGERKMAQQNKLLGNFQLGDIPPAPRGVPQIEVSFDINADGILKVSAKDKSTGKEQSIQIKANSGLSDAEIEAMIKDAEANAEEDRKFEELAKARNEADALISSSNKAVKDLGDKVTEDEKTAVNTAVSELEAATKENDVEVIKAKTEALQNILMPITQRAYEQAQQAGGAEGFDPNAFQGGDAGQQKADDGVVDAEFTEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: LEU1_BUCUE
Sequence: DGEQALQASLSVEEKLXIALCLEKTGVDIMEVGFPISSPGDFKSVQTISKKIKNSQICSLARCIEKDIDIAGEAMSVCDFFRIHIFLATSRLHMKSKLRKNFDEIIDMAIFSVKRALRYTDDVQFSCEDASRTTIDNLCRIVEKLINSGVKTINIPDTVGYSIPNELSFIIKNLFQRVPNIDKAVISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVREKNLGVYTNINHKEIYRTSQMISRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIIDPVSIGLKNVQLNLTSRSGRAAVKYYMNEMGYKDSDYNIDELYSDFLKLADKKGQVFDYDLESLAFISKQQDELEYFCLKFFSVQSISNGLSTASVKLLCGKKVYTESSTTSNGPVDAIYQALNRITHFPITLQKFQLIAKGKGKDALGQVDILVEYKKRKFHGVGLATDIIESSAKAMINVLNNIWKAKQVNKKLKILKKK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: NHP6A_YEAST
Sequence: MVTPREPKKRTTRKKKDPNAPKRALSAYMFFANENRDIVRSENPDITFGQVGKKLGEKWKALTPEEKQPYEAKAQADKKRYESEKELYNATLA
What is the function of this protein?
DNA-binding protein that induces severe bending of DNA.  Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.  Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.  Required for transcriptional initiation fidelity of some but not all tRNA genes.  Seems to be functionally redundant with NHP6B.
What are the official names of this protein?
Non-histone chromosomal protein 6A.
What is the protein family that this protein belongs to?
Belongs to the NHP6 family.
Protein: ERFD_SCHPO
Sequence: MLVRIERDYSVSGDKYPQFPTDYPVPLRAYVNLEDWDVFIHTLNEKLREAFCPWSIGNLLDGILSVLTIYISEFVFGSIHRKRIGAIDLYILDFATQHNLYVASLRNMGFLSLVFHTKETNSKSSTLHSNPYCPEHHSIRTLPSAVTATTSNISTSSSHRSDLPNEWTNSTL
What is the function of this protein?
The erf2-erf4 complex is a palmitoyltransferase with a major role in driving sexual development (PubMed:23843742, PubMed:16303567).  Palmitoylates ras1 (PubMed:23843742).  Palmitoylates isp3 (PubMed:23843742).  Palmitoylates rho3 (PubMed:23843742).
What are the official names of this protein?
Ras modification protein erf4, Meiotically up-regulated gene 91 protein.
What is the protein family that this protein belongs to?
Belongs to the ERF4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: PROA_CORJK
Sequence: MTNSNEAQENALSPERQAERDEVLAKAKKAKEVSSQLLLNTQQKNDLLADAADALEANAADIIAANEKDIATGKERGFADSLLDRLALDTERISGIAGGLRQVIGLSDPVGEIVRGHTRPNGLRMKQVRVPLGVMGMVYEARPNVTVDAFGLAIKSGNVPLLRGSKSARHTNEKLVQILQDVAESHNLPRELVQLLPCDTHDSVQDLITARGLVDLVIPRGGAGLINAVVLGATVPTIETGTGNCHFYIDSSADIEEATKLVINGKTRRCSVCNATEVVLLDSALPDPDKIYVLQELQKAGVTLHGEKKQLDPLINDVVQAEETDWTDEYLSFDIAVAIVDGVEEAVAHINRYGTSHTEGIAARDYKTTSYFEQYVDAAAVSINTSTAWTDGEMFGFGAEIGISTQKLHARGPMGLPELTSTKWVINGEGQVRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_MYCGE
Sequence: MGKYQPSFQTKKGWTEVICGPMFSGKTEKLLHKIKRWKIAKISVVIFKPIIDTRQTNIVKSRNGEYDQAITINSPFEIYDHLVDKNYQIVAIDEAQFFSNEIIEVVTTLNEIGTNVIISGLDTDFRAEPFGCIPQLLAIADVVNKLDAICNVCGSLAQRTQRLVNKNTNDNLVLIGDAEAYEARCKLHHSFLTKKHVTVKTKNFKEQVQGKTQ
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUX1_HUMAN
Sequence: MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG
What is the function of this protein?
Probable transcription activator.  Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'.
What are the official names of this protein?
Double homeobox protein 1.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus. Note=Actively transported through the nuclear pore complex (NPC).
Protein: CAIMP_PANIM
Sequence: GDCLPHLKRCKADNDCCGKKCKRRGTNAEKRCR
What is the function of this protein?
This toxin affects the activity of ryanodine receptors 1, 2 and 3 (RyR1, RyR2 and RyR3) (PubMed:1334561, PubMed:9565405, PubMed:11867448).  At lower concentrations the toxin increases full openings of the RyRs, and at higher concentrations it inhibits full openings and induces openings to subconductance levels (30% of the full conductance state) and reduces the number of full conductance openings (PubMed:9565405, PubMed:27114612).  The different actions may be attributed to the toxins binding at different sites on the RyRs, with binding at a high-affinity site mediating the increase in full openings and the induction of subconductance states evoked upon binding to a lower-affinity site (PubMed:14699105).  Furthermore, it triggers calcium release from sarcoplasmic vesicles (11. 7 nM are enough to induce a sharp release, and 70% of the total calcium is released after toxin (100 nM) addition) probably by acting as a cell-penetrating peptide (CPP) (PubMed:1334561, PubMed:27114612).  In addition, it has been shown to dose-dependently stimulate ryanodine binding to RyR1 (EC(50)=8. 7 nM) (PubMed:27114612).  It also augments the bell-shaped calcium-[3H]ryanodine binding curve that is maximal at about 10 uM calcium concentration (PubMed:27114612).  It binds a different site as ryanodine (PubMed:9565405).  It acts synergistically with caffeine (By similarity).  In vivo, intracerebroventricular injection into mice induces neurotoxic symptoms, followed by death (By similarity).
What are the official names of this protein?
Imperacalcin, IpCa, Imperatoxin activator, Imperatoxin-A, IpTxa.
What is the protein family that this protein belongs to?
Belongs to the scorpion calcin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AAS_ERWT9
Sequence: MVLTFLRALLRLAFRTRLTGDLASLNKRRVLITPNHMSFLDGILLAVFLPVKPVFAVYSSISSQWYMRALRSLIDFVPLDPTKPMSVKHLVKLIGQGRPVVIFPEGRITVTGSLMKIYDGAGFVAAKSQATVVPLRIEGAEYTPFGRLGGVVKRRLFPRITLTVLPATTIPMPQAPRARDRRRLAGEHLHHIMMEARMAVRPRETLYQAFLAARTRYGLFKPCIEDVNFKPDSYSGLLKKSLGVGRILERYSQPGEYVGLLLPNATVTAAAILGASMRGRVPAMLNYTAGVKGLTSALTAGEIKTVFTSRQFLDKGKLWHLPQGITQVKWIYLEDLKDTLTTQDKLWILGHLLLPRRAMVAQQPEDAAMVLFTSGSEGHPKGVVHSHKSLLANVEQIRTVADFTPCDRFMSALPLFHAFGLTVGLFTPLMTGARVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFARLRYVVAGAEKLQDHTRELWMEKYGIRILEGYGVTECAPVVAINVPMAAKSHTVGRILPGMDSRLVSVPGIEQGGRLQLRGPNIMKGYLRVEHPGRLEAPQADNGEGQMEPGWYDTGDIVSFDEGGFCQIQGRVKRFAKIAGEMVSLEIVEQIARNASDDKQHAATIKPDGNRGEALVLFTTDAQLTREQLMHSARELGSPELAVPRDIRLLSQLPLLGSGKPDFVTLREMAEQPEDRRE
What is the function of this protein?
Plays a role in lysophospholipid acylation.  Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium.  Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
What are the official names of this protein?
Bifunctional protein Aas.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS9_CAMJE
Sequence: MATTYATGKRKTAIAKVWVKPGSGKISVNGVDLNTWLGGHEAIKLKVVQPLLVTKQETSMDIKATTLGGGYSAQAEALRHGISRALAAMDADFRALLKPKGLLTRDSRTVERKKYGRRKARRSPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: GLPX_ECOL6
Sequence: MRRELAIEFSRVTESAALAGYKWLGRGDKNTADGAAVNAMRIMLNQVNIDGTIVIGEGEIDEAPMLYIGEKVGTGRGDAVDIAVDPIEGTRMTAMGQANALAVLAVGDKGCFLNAPDMYMEKLIVGPGAKGTIDLNLPLADNLRNVAAALGKPLSELTVTILAKPRHDAVIAEMQQLGVRVFAIPDGDVAASILTCMPDSEVDVLYGIGGAPEGVVSAAVIRALDGDMNGRLLARHDVKGDNEENRRIGEQELARCKAMGIEAGKVLRLGDMARSDNVIFSATGITKGDLLEGISRKGNIATTETLLIRGKSRTIRRIQSIHYLDRKDPEMQVHIL
What is the function of this protein?
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate.
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 2, FBPase class 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 2.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL6_HORSE
Sequence: MNSLSTSTVTPVAFSLGLLLVMATAFPTPLPLGEDETTSNGPLLTTADKTKQHIKYILGKISALKNEMCNNFSKCENSKEVLAENNLNLPKMAEKDGCFQSGFNQETCLMKITTGLSEFQIYLEYLQNEFKGEKENIKTMQISTKVLVQILMQKMKNPEVTTPDPTAKSSLLAKLHSQNEWLKNTTTHLILRSLEDFLQFSLRAVRIM
What is the function of this protein?
Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability.  Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF.  Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity).  'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis.  Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity).  Also acts as a myokine (By similarity).  Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity).  Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity).  Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
What are the official names of this protein?
Interleukin-6, IL-6.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL30_BORGP
Sequence: MEKNREIISKNNINVQVFLVRSLIGKLNKKVKVLKALGLNKIGDKKVHFLNESIKGMLNETINMILLSEVNNV
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: Y3365_RHIL3
Sequence: MTIDDDLSRIAEQEKVLSFDAFDLTTAWQLGKLLQELATERGLGIAIDVTLHSMPVFYAALPGVTPDNVNWVRRKRNMVLRYFRSSYASGLKLQKDGKTVEDNGLSGADYAPHGGSFPINVKGSGCIGAVTVSGLPQRDDHNLAVEALALMLAKDLDTLRLA
What are the official names of this protein?
UPF0303 protein RL3365.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: RS21_SALTI
Sequence: MPVIKVRENEPFDVALRRFKRSCEKAGVLAEVRRREFYEKPTTERKRAKASAVKRHAKKLARENARRTRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.