PharMolix/UniProtQA huggingface dataset:
Protein: GAD_SACS2
Sequence: MRIREIEPIVLTSKEKGSATWASIMIVTRVITENGEVGYGEAVPTLRVISVYNAIKQVSKAYIGKEVEEVEKNYHEWYKQDFYLARSFESATAVSAIDIASWDIIGKELGAPIHKLLGGKTRDRVPVYANGWYQDCVTPEEFAEKAKDVVKMGYKALKFDPFGPYYDWIDERGLREAEERVKAVREAVGDNVDILIEHHGRFNANSAIMIAKRLEKYNPGFMEEPVHHEDVIGLRKYKASTHLRVALGERLISEKETAFYVEEGLVNILQPDLTNIGGVTVGRSVIKIAEANDVEVAFHNAFGSIQNAVEIQLSAVTQNLYLLENFYDWFPQWKRDLVYNETPVEGGHVKVPYKPGLGVSINEKIIEQLRAEPIPLDVIEEPVWVVKGTWKNYGV
What is the function of this protein?
Involved in the degradation of glucose and galactose via the branched variant of the Entner-Doudoroff pathway.  Catalyzes the dehydration of gluconate to produce 2-keto-3-deoxygluconate (KDG).  It is also able to catalyze the dehydration of galactonate to produce 2-keto-3-deoxygalactonate (KDGal).
What are the official names of this protein?
D-gluconate/D-galactonate dehydratase, GAD, GNAD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GaD subfamily.
Protein: CHAL_BRARR
Sequence: QAGGQTCAGNICCSQYGYCGTTADYCSPDNNCQATYHYYNPAQNNWDLRAVSAYCSTWDADKPYSWRYGWTAFCGPAGPRCLRTNAAVTVR
What are the official names of this protein?
Chitin-binding allergen Bra r 2.
Protein: NRDR_MYCTA
Sequence: MHCPFCRHPDSRVIDSRETDEGQAIRRRRSCPECGRRFTTVETAVLAVVKRSGVTEPFSREKVISGVRRACQGRQVDDDALNLLAQQVEDSVRAAGSPEIPSHDVGLAILGPLRELDEVAYLRFASVYRSFSSADDFAREIEALRAHRNLSAHS
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: SNAT_RAT
Sequence: MLSIHPLKPEALHLPLGTSEFLGCQRRHTLPASEFRCLTPEDATSAFEIEREAFISVSGTCPLHLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKERLTQESLTLHRPGGRTAHLHVLAVHRTFRQQGKGSVLLWRYLHHLGSQPAVRRAVLMCENALVPFYEKFGFQAMGPCAITMGSLTFTELQCSLRCHTFLRRNSGC
What is the function of this protein?
Controls the night/day rhythm of melatonin production in the pineal gland.  Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
What are the official names of this protein?
Serotonin N-acetyltransferase, Serotonin acetylase, Aralkylamine N-acetyltransferase, AA-NAT.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. AANAT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP1_LACAC
Sequence: MVQAINLKKGMIFSQDGKLIKVLKANHHKPGKGNTVMQMDLRDVKSGAVVHKTMRPTEKVDLVEVTKKSAQYLYNEGDNYTFMDTDTYDQYEVSADQLGDDIKFLMPNIVVDMDFTDDNKIIGIELPSTVEMTVKETQPGIKGATVAGGGKPATMETGLVVQVPDFINEGEKLVIGTENGDYKSRANSQPR
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P 1, EF-P 1.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2916_YERPA
Sequence: MDYEFLRDLTGQVLVKFSMGHEVIGHWLNEEIKGDLVKLDHIETAADGVRGSERQWQLPGHEYTLWLDGEEVMVRANQLDLDGDEMEEGMNYYDEESLCLCGLEDFLLVLKGYRAFITQ
What are the official names of this protein?
UPF0231 protein YPA_2916.
What is the protein family that this protein belongs to?
Belongs to the UPF0231 family.
Protein: Y2531_RALSO
Sequence: MDNRLLEILVCPLCKGTLQHDRAHNELICHVDKLAYPIRDGIPVMLADEARQTVEGTPVDPA
What are the official names of this protein?
UPF0434 protein RSc2531.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: MSHA_SANKS
Sequence: MSGDSLRVAMLSVHTSPLEQPGTGDAGGMNVYITELSRALARSGAEVEIFTRRTSSAQPDVVEVGDGILVRHITAGPFEGLDKNDLPGQLCYFSAGVLRTEAARTQGWYDVVHSHYWLSGQAGMLAADRWNVPLVHSMHTMALVKNGSLAPGDVPEPAGRVIGEEQVVEVADALVANTAAEAEDLVTHYAADPTRVHVVSPGVDLETFTPLPPAGADGARDTAAAERAALGLPADRKVVVFAGRVQLLKAPDVLVRALGVMADHGDELPLLVVLGGASGRPTALRELEALAYQVGVSDDVLFLPAVSRSELARWFRCADLVAVPSRSESFGLVAVEAQACGTPVVAADVGGLRTAVQDGRSGVLVPDHDPHRWAAVLRDLLRDDERLARLSRGALEVAAHFSWDTTAEETRKVYEQARVA
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: UVRD_MYCPN
Sequence: MAFNISTQLNKEQRAAVTCGKGVNIVYSGAGTGKTTIISQRFAYLFNQKRINPSNILALTYTRKAASEMKQRILELLPEKYHKDVNIYTFHSFCSRFLREEGQKNFVIDDDLSNFLKDFLKESELKSQKVLQIIDGFKNAYFDFDTNSLKDDERLVELCEFHLDPQERNFQLFKETAIAAFVEYEKGKQQNNKIDFADLLIKTCTLLSKDHKLLRKWSKKFQYILGDEFQDTNQIQYELIKMLASHHQNLFLVGDNNQMIYRWRGAVSDIIDSLKSDFKVRPENEFYITQNYRCDQNILTVANSILGTIYAKENQPDSTKGFLFSAIKSNRLPVYFQASSVEGQHSWIINKIKNLHKNHGIQYKDMAILFRTNRNMDSMTEALEADGSIPLKQNKGFFKQLETFKKVLVALITRSNYDIKLALKSLRVWPNVLNKSLTVNEQVNLDKILQNLEQAIFLDEHTRGELTEAAKVFTRLIKFVEEQQFEALLAFTFEALNTDQFVCNFIFRTLQKLQTENKNFTITDFINELRFQQDELKQSKDNVINLITVHSAKGLEFEAVFIYGINQDNFPLKSKNQIIDLQRELDELRLFYVALTRAKKYLFLLSVYQMSGEIIYPSKFIRFINKEDRLEIATINHKVHQDDEFFDSSKTEDYQKKYLTENTDFVNGDSVSHRTYGKGVVVEVREDAVCVAFKNSKYGQRWIVKNHRDLVKAVY
What is the function of this protein?
Has both ATPase and helicase activities.  Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present.  Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity).
What are the official names of this protein?
Probable DNA helicase II homolog, DNA 3'-5' helicase II.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
Protein: PRMA_SYNR3
Sequence: MPAAAQPSWWRLELEPPGELEESLLWRLESLGVHRLAVRFRPEAPEQRTLQAWLPEVDWPEPERVALAEALAQMAEPFGVALPSLRWELQPEEDWALSWKRHWQPDPVGQRLLILPAWLQVPAEHAERLALLIDPGSAFGTGSHPTTRLCLEALEKRSLTGSRVADLGCGSGILGIASLVLGAREVLASDTDSLAVRATAENAALNQAGAHLQVQLGSADVLQQLLAGAPADLLLCNILAPVLTALTPAFSELLTARGEGLLSGLLVDQAPALTAHLEAHGWRVTTEAEQGRWALLAIQRA
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_ALHV1
Sequence: MEEWLRKHMWPALPDHQHHPSYDILLAEPWVQFLDMTPFFRQKLYNTLSKINEMRKSCIIYPPQAEIMSWSYLCAPEDVKVVIIGQDPYHGGQANGQAFSVNKGFPVPPSLQNIFKEVRSCYPDFVSPGHGCLEEWGRQGVLLLNTILTVEAKKPGSHSDLGWTWFTNLIISTLSNKLNNCVFMLWGSKAIAKSLMINKQRHLVLKAQHPSPLAAKNNYSSSQCKFLGCGHFLTANKYLTQHNKVPIDWTLE
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines.  Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG, UNG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: COAX_HALOH
Sequence: MILAIDVGNTNTVMGIYKKDKLIQHWRISTDKNKTPDEYGILFLNLFNSANVNYKRIDGIILSSVVPPLVRILKKMTTRYFNLEPLVVGPGIRTGINLKMDNPREVGADQVVNAVAAYHKYGGPLIIVDFGTATTFCAVSERGEYLGGAIAPGIGISAEALYSYAAKLPRVEFKTPGQAIGKNTVAGMQSGIIYGFVGLVEALVKRFKDELKETPEVIATGGLVSLIASETDEIDKVDPFLTLDGLYYIAKINGIVE
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_PINMU
Sequence: MDEFHRCGKEDSFWQQCFLYPLFFQEDLYAISHDHYLDVSSSSRPMEHLSSNDQLSFLTVKRLIGQIRQQNHSIVLFVNCDPNPLADRKKSFYSESVLEALTLVLEVPFSIWSKSSVEGMNECKSFRSIHSIFPFLEDKFPHSNSILDARIPYSIHPEILVRTFRRWIRDAPSLHPLRSVLYDYRNSPENLQRSIIVVPRVNTRFFLFLLNYYVCECESILFSRLKRSSHSRSLSHGSFPQRTHFHRKIKHIIIFSRRNSLKSIWSLKDPKIHYVRYGERPIIAIKGADLLVKKCRYYLLIFRQFYFHLWSEPYRVCSHQLSKNCSSSPGYFLRVRMNPLLVRTKTLDELFIPVLITNEMDPIVPIVPIIGLLATEKFCDISGRPISKLSWTSLTDDDILDRFDQIWRNLFHYYSGSFDRDGLYRIKYILLLSCAKTLACKHKSTIRVVRKELGPELFKKSFSKEREFDSLPFSSKAAARSQRERIWHSDIPQINPLANSWQKIQDLKIENLFDQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRXH1_TOBAC
Sequence: MAANDATSSEEGQVFGCHKVEEWNEYFKKGVETKKLVVVDFTASWCGPCRFIAPILADIAKKMPHVIFLKVDVDELKTVSAEWSVEAMPTFVFIKDGKEVDRVVGAKKEELQQTIVKHAAPATVTA
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide.  The H form is known to activate a number of cytosolic enzymes (By similarity).
What are the official names of this protein?
Thioredoxin H-type 1, Trx-H1.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant H-type subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP1_ENTFA
Sequence: MLFANLWKAIILGIIEGITEWLPISSTGHLILVDEFIKLDLSKDFMEMFNVVIQLGAIMAVVILYFHKLNPFSPKKNGEEKKDTWILWSKVLVACLPAAVIGLKFDDYLDAHFYNFLTVSIMLIVYGIAFIIIEKRNKNVAPKCTNLKDFTYKAALIVGAFQVLALIPGTSRSGATILGAILIGASRFVATEFSFFLGIPVMFGASFLKIFKFLAKGNTFGSEEIIILITGSIVAFVVSIIAIKFLLNYLKKNDFTVFGWYRVILGAILIGYWLFS
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin (By similarity).
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PROQ_YERPS
Sequence: MENQPKLNSSKEVIAFLAERFPLCFTAEGEARPLKIGIFQDLVERVQGEENLSKTQLRSALRLYTSSWRYLYGVKVGAERVDLDGNPCGVLEEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAIAAGETPEPRRPRPAGKKPAPRREAGAAPENRKPRQSPRPQQVRPPRPQVEENQPRPVPVTDISKLQIGQEIKVRAGKSAMDATVLEIAKDGVRVQLSSGLAMIVRAEHLQF
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.  May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TASK_HAPIR
Sequence: MDDQKGPLPPYTPTATAPPPASMRQRRPPGRRRALRRSRTVRVLALACLAFVVLAQWKQLWRGERKAPPYLSVDKLNDNLETCRKLRVRPQDPAGPGRSKNDRYLDGGGKPTLIRNALIWTGEPVPGTSDEDARAGVGWAWWLGDVLVERGLITKVDNKMPASEVPEDAIIYDAEGRRLTSGIVDMHSHAGVSPLPGLNGNDDTNEASDNITPWARSIDGLFPLDPQIQVIKSGGVTSSLILPGSANNIGGEAFLIKHAVGRHDGRPELSAASMLADPDRTWRYMKMACGENAKRVHGSRTTRPVTRMGESYDFRRAFERASQLVRRQDDWCDRAGEVGVGSMDEYLPEDLEWEALGAALRGQVHVNAHCYTVNDLEAMVDHSNEFEFPIRAFHHAHQAHLVPEILNRTWGGRPPALAIFADNMYYKAEAYIGTPSAGKMLYDQGLTPIYVSDNPVLNAQHVVLEAAKGFHYGLPYHAALASVTTAPADTLGMGQRLGKIKAGFDADIVVWDSDPLGVGAAPVQVWIDGTAQFDDPVVLSKPHARAEKDTVVVPDAPPPVVVEEPVEVADVLFRGVTRVLLDEHDVSAEDGASLNVAIRGGRISCIGECADEFRVAIDAGVGVVTLGNGHLHKTFVGVGGTLGLNEIDGESKTGNGKNPKTFTRAVDGLLLGGKKLRAAHHAGVTRAISAPRFKGGGNTHHGTSVGIVTSARTSLDAGAIFGNGDVAVHYTLDLSVRGGDDESYSAAFGSLREKLIRAGVHGGKEKEVGAEEVGAEEEEEEEEKAFLRRVLASEMVLALTINSADGIATALRIKDEVDKKQQKQQQQQQQQQQQQHGTSSGIRMAIIGGAEAYLVAEHLAAANVGVILSPLQSYGETWDARRALPGAPLTNGTNIDRLLDAGVKVGIGLKEDWEVRDLALAAGTAYENGGGRLTGRQALDLVGRNVLEILGVEEEEETPGATMGESGHFVVLLIINMFCGL
What is the function of this protein?
Amidohydrolase; part of the gene cluster that mediates the biosynthesis of the tetramic acids Sch210971 and Sch210972, potential anti-HIV fungal natural product that contain a decalin core (PubMed:25885659).  The PKS module of tasS together with the enoylreductase tasC catalyze the formation of the polyketide unit which is then conjugated to 4-hydroxyl-4-methyl glutamate (HMG) by the condensation domain of the tasS NRPS module (PubMed:25885659).  One unique structural feature of Sch210971 and Sch210972 is the tetramic acid motif proposed to be derived from the non-proteinogenic amino acid HMG, by a Dieckmann-type condensation catalyzed by the reductase domain of tasS (PubMed:25885659).  The aldolase tasA catalyzes the aldol condensation of 2 molecules of pyruvic acid to yield the intermediate 4-hydroxyl-4-methyl-2-oxoglutarate (HMOG), which can then be stereoselectively transaminated, may be by tasG, to form HMG (PubMed:25885659).  The Diels-Alderase tas3 then uses the Dieckmann product of tasS as substrate and catalyzes the Diels-Alder cycloaddition to form the decalin ring of Sch210971 and Sch210972 (PubMed:25885659).
What are the official names of this protein?
Amidohydrolase tasK, Tetramic acid Sch210971/2 biosynthesis cluster protein K.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: METE_CHRSD
Sequence: MALAHILGYPRIGANRELKKAVEAYWKGDIDQAELERRGQALRAEHWQASRDAGLDFVTVGDFAFYDQVLNVSAMLGAVPPRFGAIDGDVDLDTTFRMARGRAPSGTPAAACEMTKYFDTNYHYLVPELHAGQRFRVASTRLFDEVAEAQAAGHPVKVALLGPVSWLWLGKEKSAGLDRLTLLDDVLSVYGEILERLAAQGVEWVQLDEPALVQDLPRDWRQAFESAYNKLQSAPVKLLLATYFGALGDNLGLAAGLPVAGLHIDTVRAPEQLDAVLDRLPTYKVLSLGAIDGRNIWRADLAALRERLQVARARLGERLWISASCSLLHVPVDLDAETDLDAELKSWLAFARQKLDEIVTLAHLLDGRATPEDTARLEAATSALDARRQSPRIHKPAVGERLAAVSADDAERASPYATRAKAQHRHLDLPLFPTTTIGSFPQTQDIRAARRAFKSGELSRDDYEARMRDEIAHAVERQEALAIDVPVHGEPERNDMVEYFGELLDGFAFTRFGWVQSYGSRCVKPPVIFGDVSRPGPMTVRWSEYAQSLTDKPMKGMLTGPVTILQWSFVRDDQPRDATCRQIALSLRDEVADLEAAGIKIIQIDEPALREGLPLRQGEWQEYLDWAVKSFKLSAAVARDETQIHTHMCYSEFNDIIAAIAALDADVITIETSRSDMELLDAFQDFAYPNEIGPGVYDIHSPNIPEVEWMVSLMEKAAEKIPAERLWVNPDCGLKTRGWAEVEPALANMVEAARELRRRYG
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: DEGPL_PSEMY
Sequence: MRNLKSVTPLLMAALLWGQSLLAQASLPDFTALVEEASPAVVNISTRQKMPERSVAAQPGLPDLEGLPPMFREFFERSIPQMPRNPGGRQREAQSLGSGFIISADGYVLTNNHVVADADEIIVRLSDRSELEAKLIGADPRSDVALLKVEGKGLPTVRLGKSDELKVGEWVLAIGSPFGFDHSVTAGIVSAKGRNLPSDSYVPFIQTDVAINPGNSGGPLFNLKGEVVGINSQIFTRSGGFMGLSFAIPMEVALQVSEQLKADGKVTRGWLGVVIQEVNKDLAESFGLDRPAGALVAQVLEDGPADKGGLQVGDVILSLNGKPIVMSADLPHLVGGLKPGEKAEMDVVRDGSRKKLKVTIGTLPEEGQELAAAGSTKGGERSSNRLGVTVVELTAEQKKGLDLRGGVVVKEVLSGPAAMIGLRPGDVITHLNNQAIDSTATFAKVAQELPKNRSVSMRVLRQGRASFITFKLAE
What is the function of this protein?
Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.
What are the official names of this protein?
Probable periplasmic serine endoprotease DegP-like, Protease Do.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Periplasm.
Protein: YJGA_SALG2
Sequence: MTKQPEDWLDDVPGDDIEDEDDEIIWVSKSEIKRDAEELKRLGAELVDLGKNALDKIPLDADLRDAIELAQRIKMEGRRRQLQLIGKMLRQRDVEPIRQALDKLKNRHNQQVVLFHKLEHLRDRLIVEGDDAVVEVLTLWPHADRQQLRSLIRNAKKEKEGNKPPKSARQIFQYLRELAENEG
What are the official names of this protein?
UPF0307 protein YjgA.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: ILVC_HAEIE
Sequence: MANYFNTLNLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMPLMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKESLGFLYYKHMDDIISGHFSATMMADWANGDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVLMIAMVKAGVELAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSNVATPILAKEIIPNLQKGDLGEPTPAVEVDNITLRDVNDAIRNHPVELIGQELRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SRY_AXIPR
Sequence: MFRVLNDDVYSPAEIQQQNPLAFGKASSLFTDNRSANDQCETGENVRESGQDHVKRPMNAFIVWSRERRRKVALENPKMQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAVHRDKYPGYKYRPRRKTKRQQKLLPADSSKLCKQMHIETLQPFIYRDGCANTTGSRMESQLSLSQSVTITNSFFQNEHHRSWTNLGHNRVTLATQISADFPFYQSLQPGLSCAYFQY
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: NU1M_DROTR
Sequence: MEFILSLVGSLLLVICVLVSVAFLTLLERKVLGYIQIRKGPNKVGLMGIPQPFCDAIKLFTKEQTYPLLSNYLSYYISPIFSLFLSLFVWMCMPFFVKLYSFNLGGLFFLCCTSLGVYTVMVAGWSSNSNYALLGGLRAVAQTISYEVSLALIGFKILLFSLL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PDXH_AGRVS
Sequence: MSQNELTTGDFTDEHEPFGLFETWLTEAKASEINDPNAVALATVDESGLPNVRMVLLKDFDQNGFVFYTNFESQKGTEILSQKKAAMCFHWKSLRRQVRLRGEVEVVSDAEADAYYQTRPIGSRIGAWASKQSRPLESRFALEKAVAEYTARYALGSIPRPAHWSGFRIKPLTIEFWRDGKFRLHDRIEFRREALGQPWNKVRMYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: Y1856_VIBVU
Sequence: MYPHLTGLGIHDPSQIERYSLRQEAHKDVLKIYFHKQKGEFFAKSVKFKYPRQVKNVLVDSGSHQYKEVTEINRNLTLVIDELNKITKPPKQEDVDIKQKILTDLKHLEKVVASKIAEIEADLEKLK
What are the official names of this protein?
UPF0325 protein VV1_1856.
What is the protein family that this protein belongs to?
Belongs to the UPF0325 family.
Protein: DPOL_WHV1
Sequence: MHPFSRLFRNIQSLGEEEVQELLGPPEDALPLLAGEDLNHRVADALNLHLPTADLQWVHKTNAITGLYSNQAAQFNPHWIQPEFPELHLHNELIKKLQQYFGPLTINEKRKLQLNFPARFFPKATKYFPLIKGIKNNYPNFALEHFFATANYLWTLWEAGILYLRKNQTTLTFKGKPYSWEHRQLVQHNGQQHKSHLQSRQNSSVVACSGHLLHNHLPSEPVSVSTRNLSNNIFGKSQNSTRTGLCSHKQIQTDRLEHLARISCRSKTTIGQQGSSPKISSNFRNQTWAYNSSWNSGHTTWFSSASNSNKSRSREKAYSSNSTSKRYSPPLNYEKSDFSSPGVRGRIKRLDNNGTPTQCLWRSFYDTKPCGSYCIHHIVSSIDDWGPCTVTGDVTIKSPRTPRRITGGVFLVDKNPNNSSESRLVVDFSQFSRGHTRVHWPKFAVPNLQTLANLLSTDLQWLSLDVSAAFYHIPISPAAVPHLLVGSPGLERFNTCLSYSTHNRNDSQLQTMHNLCTRHVYSSLLLLFKTYGRKLHLLAHPFIMGFRKLPMGVGLSPFLLAQFTSALASMVRRNFPHCVVFAYMDDLVLGARTSEHLTAIYTHICSVFLDLGIHLNVNKTKWWGNHLHFMGYVITSSGVLPQDKHVKKLSRYLRSVPVNQPLDYKICERLTDILNYVAPFTLCGYAALMPLYHAIASRTAFVFSSLYKSWLLSLYEELWPVVRQRGVVCSVFADATPTGWGIATTCQLLSGTFAFPLPIATAELIAACLARCWTGARLLGTDNSVVLSGKLTSFPWLLACVANWILRGTSFCYVPSALNPADLPSRGLLPVLRPLPRLRFRPPTSRISLWAASPPVSPRRPVRVAWSSPVQNCEPWIPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: UBIC_PECCP
Sequence: MSDDVSTLLRTISWFAEPPSVLPEHIGDWLMETSSMTQRLEKYCAQLTVTLCREGFVSPQSLGEESEQLPPDERYWLREVVLYGDERPWLFGRTIVPQQTLDGTDSALTKIGNQPLGRYLFEQKSLTRDYIHTGCCEGLWARRSRLCLSGFPLLLTELFLPESPVYYTPSDEGWQVI
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.