PharMolix/UniProtQA huggingface dataset:
Protein: MAK5_VANPO
Sequence: MVNKFLAGRLKKSKGKSFKGSSSKGNSKTVKSNNNDNVVVNAADLKWKPVEIPDTLDDFEGFYGLEEIDGVGVKIVGGQVQFVAHDDTKINGNEDNLDSKDKIEIDEDAPENDLVEFKNMDDMKDGELTDNSQSESEAEAESEAESEEEEEKTGDDEGEDGAEKVDNEVLKTNVFNTDIDLEDITPSDLPEWTEKVGELSFTTLHGLTKLGFNKPTLIQEEAIPMALKGEDIMGKASTGSGKTLAYGIPIIEKLMKSKSNTAPIGLIFTPTRELAKQVTDHLRKIASLIVDKSPHAILSLTGGLSIQKQERLLKYEGSGRIVVATPGRFLELIEKDKTLVERFSQISTLVLDEADRLLQDGHFDEFENILKYLGRESKNRKHNWQTMIFSATFATDLFDKLSHASWKNMKTPSKNENEMEIVLKHLMTKIHFKSKPILIDANPEDKVSSQIKESLIECAATERDLFCYYFVSMYPGKTLIFCNAIDSVKKLTAYLNNLNISCFQIHSSMTQKNRLRNLERYQQQSEKNKILGKPTVLVGSDVAARGLDIPGIQHVIHYHLPRTADVYIHRSGRTARANNEGVSVMICSPEEAMGPLRKLRKTLANKSGKDIIMGKKKWQKTVTMLPIDDTILSQLKERSRLASELADHDLASSSLQKDDTWMKKAAEDLGVDIDSDDEIKDTFLAKNINKKRNKTLGKDQKKVLVAQLNDLLKRPLRKDMRQRYLTGGLVNLADSLVKKRGHDHIIGHEKTDALETLKNKKRK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase MAK5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL15_CAMC5
Sequence: MALQNLTPAPGSTHATKRLGRGQGSGNGKTAGKGNKGQRARKGYNEKRGFEGGQQPLQRRLPKVGFTSKFEKPYVINVEKITAIKELSEITVATIASVHKISKSVTKIKLIGVSAKELASKVKDENVSVSGSK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: CEP83_HUMAN
Sequence: MVVSTFTDMDTFPNNFPPGGDSGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEELGSSGE
What is the function of this protein?
Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly.  May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly.
What are the official names of this protein?
Centrosomal protein of 83 kDa, Cep83, Coiled-coil domain-containing protein 41, Renal carcinoma antigen NY-REN-58.
What is the protein family that this protein belongs to?
Belongs to the CEP83 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to centrioles at all stages of the cell cycle, including mitosis.
Protein: NICA_DROME
Sequence: MEMRLNAASIWLLILSYGATIAQGERTRDKMYEPIGGASCFRRLNGTHQTGCSSTYSGSVGVLHLINVEADLEFLLSSPPSPPYAPMIPPHLFTRNNLMRLKEAGPKNISVVLLINRTNQMKQFSHELNCPNQYSGLNSTSETCDASNPAKNWNPWGTGLLHEDFPFPIYYIADLDQVTKLEKCFQDFNNHNYETHALRSLCAVEVKSFMSAAVNTEVCMRRTNFINNLGGSKYCDPLEGRNVYATLYPRKPAIENNLETVHTNEKFILVTCRLDTTTMFDGVGLGAMDSLMGFAVFTHVAYLLKQLLPPQSKDLHNVLFVTFNGESYDYIGSQRFVYDMEKLQFPTESTGTPPIAFDNIDFMLDIGTLDDISNIKLHALNGTTLAQQILERLNNYAKSPRYGFNLNIQSEMSAHLPPTSAQSFLRRDPNFNALILNARPTNKYYHSIYDDADNVDFTYANTSKDFTQLTEVNDFKSLNPDSLQMKVRNVSSIVAMALYQTITGKEYTGTKVANPLMADEFLYCFLQSADCPLFKAASYPGSQLTNLPPMRYISVLGGSQESSGYTYRLLGYLLSQLQPDIHRDNCTDLPLHYFAGFNNIGECRLTTQNYSHALSPAFLIDGYDWSSGMYSTWTESTWSQFSARIFLRPSNVHQVTTLSVGIVVLIISFCLVYIISSRSEVLFEDLPASNAALFG
What is the function of this protein?
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch.  It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
What are the official names of this protein?
Nicastrin.
What is the protein family that this protein belongs to?
Belongs to the nicastrin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: NFI_ECOUT
Sequence: MDLASLRAQQIELASSVIREDRLDKDPPDLIAGADVGFEQGGEVTRAAMVLLKYPSLELVEYKVARIATTMPYIPGFLSFREYPALLAAWEMLSQKPDLVFVDGHGISHPRRLGVASHFGLLVDVPTIGVAKKRLCGKFEPLSSEPGALAPLMDKGEQLAWVWRSKARCNPLFIATGHRVSVDSALAWVQRCMKGYRLPEPTRWADAVASERPAFVRYTANQP
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCD2_YEAST
Sequence: MVEKDTWKLITATALFTVAVTTITDYAWTSWQAQKQVIAQQKNKNKGGQTKSDTDKYHQYDEQFIRQSLKNNVEFLGEDTIEKLSNQYVVVVGAGGVGSWVVNSLVRSGCRKIRVVDFDQVSLSSLNRHSCAILNDVGTPKVECLRRHMREIAPWCEIDPINELWTLQNGERLTLGNGTPDFIVDCIDNIDTKVDLLEFAYNHGIKVISSMGASAKSDPTKLNVGDLATTEEDPLARVVRRKLKKRGILSGIPVVFSAEKPDPKKAKLLPLPDEEYERGKVDELSALKDFRVRILPVLGTMPSLFGLTITTWILSNISDKPLEPVEGKNRIKVYDGIYQSLAGQMSRVGIPSQRIPLALKDVSYLVEEVFKGKSPISGISTRLTLTKWDPSKPISLQNVVVLTKNEQKVHEDRVLKGKESLQDVYDAKVLKLVSQRFREEAYYSQFR
What is the function of this protein?
Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
What are the official names of this protein?
tRNA threonylcarbamoyladenosine dehydratase 2, t(6)A37 dehydratase 2.
What is the protein family that this protein belongs to?
Belongs to the HesA/MoeB/ThiF family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: POL_FIVSD
Sequence: KKFGKLEGGASCSPSESSAANSNAICTSNGGKIIGFINYNKVGTTTSLEKRPEILIFVNGYPIKFLLDTGADITILNRRDFQVKNSIENGRQNMIGVGGGKRGTNYINVHLEIRDENYKTQCIFGNVCVLEDNSLIQPLLGRDNMIKFNIRLVMAQISDKIPIVKVKMKDPNKGPQIKQWPLSNEKIEALTEIVERLEREGKVKRADPNNPWNTPVFAIKKKSGKWRMLIDFRELNKLTEKGAEVQLGLPHPAGLQMKKQITVLDIGDAYFTNPLDPDYAPYTAFTLPRKNNAGPGRRFVWCSLPQGWILSPLIYQSTLDNIIQPFIRQNPQLDIYQYMDDIYIGSNLSKKEHKEKVEELRKLLLWWGFETPEDKLQEEPPYKWMGYELHPLTWTIQQKQLEIPEKPTLNELQKLAGKINWASQTIPELSIKSLTNMTRGNQNLNSTREWTEEARLEVQKAKRAIEEQVQLGYYDPSKELYAKLSLVGPHQISYQVYQKCPEKILWYGKMSRQKKKAENTCDIALRACYKIREESIIRIGKEPRYEIPTSREAWESNLINSPYLKAPPPEVDYIHAALNIKRALSMIKDPPISGAETWYIDGGRKLGKAAKAAYWTDTGKWQVMELEGSNQKAEIQALLLALKAGPEEMNIITDSQYMINILSQQPDKMEGIWQEVLEELEKKTAIFIDWVPGHKGIPGNEEVDKLCQTMMIIEGDGILDKRTEDAGYDLLAAKEIHLLPGEVKVIPTGVKLMLPKGHWGLIMGKSSIGSKGLDVLGGVIDEGYRGEIGVIMINLSKKSITLLEQQKIAQLIILPHKHEALEQGKVVMDSERGEKGYGSTGVFSSWVDRIEEAETNHEKFHSDPQYLRTEFNLPKMVAEEIRRKCPVCRIRGEQVGGQLKIGPGIWQMDCTHFDGKIILVAIHVESGYIWAQIISQETADCTVKAVLQLLSAHIVTELQTDNGPNFKNQKMEGVLNYMGVKHKFGIPGNPQSQALVENVNQTLKVWVHKFLPETTSLDNALALAVHCLNFKQRGRIGGMAPYELLAQQESLRIQDYFSAIPQKLQAQWIYYKDQKDKKWKGPMRVEYWGQGSVLLKDEEKGYFLIPRRHVKRVPEPCALPEGDE
What is the function of this protein?
During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme.  RNase H activity is associated with the reverse transcriptase.
What are the official names of this protein?
Pol polyprotein.
What is the protein family that this protein belongs to?
Belongs to the retroviral Pol polyprotein family.
Protein: XYLC1_ACIGI
Sequence: PNIQTKIIEQIWKEHIFQGTVVK
What are the official names of this protein?
Benzaldehyde dehydrogenase [NAD(+)] I.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: PRS6B_ARATH
Sequence: MASAAVASMVLDPKASPALMDLSTADEEDLYGRLKSLERQLEFTDIQEEYVKDEQKNLKRELLRAQEEVKRIQSVPLVIGQFMEMVDQNNGIVGSTTGSNYYVRILSTINRELLKPSASVALHRHSNALVDVLPPEADSSISLLSQSEKPDVSYNDIGGCDIQKQEIREAVELPLTHHELYKQIGIDPPRGVLLYGPPGTGKTMLAKAVANHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEVDAIATARFDAQTGADREVQRILMELLNQMDGFDQTVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLVFQVCTSKMNLSDEVDLEDYVSRPDKISAAEIAAICQEAGMHAVRKNRYVILPKDFEKGYRANVKKPDTDFEFYK
What is the function of this protein?
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins.  The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
What are the official names of this protein?
26S proteasome regulatory subunit 6B homolog, 26S protease subunit 6B homolog, 26S proteasome AAA-ATPase subunit RPT3, Protein BMAA insensitive morphology 409, Regulatory particle triple-A ATPase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ANF39_ORNAN
Sequence: MHLSHLLAWALLLTLLSLRAEAKPPSPQPQVPRSPGDEASEAVAANGGGKKGDKEPKGDRPRLLRELRLDTRSRGSRGVWTRLLHDHPNPRKYKPANKKGLSKGCFGLKLDRIGSTSGLGC
What is the function of this protein?
Venom peptide 1 induces slow and continuous calcium influx in IMR-32 human neuroblastoma cells.  Venom peptide 4 weakly induces calcium influx in IMR-32 human neuroblastoma cells while venom peptide 2 was not observed to induce calcium influx.
What are the official names of this protein?
C-type natriuretic peptide, CNP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: DCTN5_PIG
Sequence: MELGELLYNKSEYIETASGNKVSRQSVLCGSQNIVLNGKTIVMNDCIIRGDLANVRVGRHCVVKSRSVIRPPFKKFSKGVAFFPLHIGDHVFIEEDCVVNAAQIGSYVHVGKNCVIGRRCVLKDCCKILDNTVLPPETVVPPFTVFSGCPGLFSGELPECTQELMIDVTKSYYQKFLPLTQV
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
What are the official names of this protein?
Dynactin subunit 5.
What is the protein family that this protein belongs to?
Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
Protein: CTAA_RHIE6
Sequence: MAVANLTTEQAILTEVRKQNRNRRALRLWLGFVLLALFCLVLVGGATRLTNSGLSITEWKPIHGVIPPLSAAEWDEEFRLYQRIPEFQQLNSAMTVDEFKGIFWWEWAHRLIARGIGVIFALPLIFFWLTGRIEKRLRWPLVGILALGGLQGFIGWWMVSSGLSVRTDVSQYRLATHLVMACLIFAGCMWIMRGLSPHSNDPAPARSSRGFAAAIAIFALFQIYLGALVAGLDAGFSYNTWPLMDGAVIPSDLLIQQPFWINAFENPKTVQFIHRIGAYTLFALTLINMVIALRAAPWTTHARRAVVLFSLVTLQAAIGIATLLMQVPLHWGLLHQAGALVVFGFAVANWRGFYGEYPHATAIAERD
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GATD_SACS2
Sequence: MQENYKGKAYDILKNLNIEEGDLIEIKKGDLRIRGILLPSYSKDDRIFVIKLDNGYNIGISIDNITEIKPIEKKSSKDRESERREVHNGAKSEIKIISTGGTIVSRVEYETGAVRPALTTEEIIQFLPEINEIAKVDAEVLFSILSENMKPEFWVKIAESVKKAFDEGNTGIVIAHGTDTMAYTASALAFSLRSLQGPVVLVGSQRSSDRPSSDSAINLLSAVITAKYAPFGEVVVNMHAESSDTYALVHRGVKVRKMHSSRRDAFQSVNDKPLAKVLWKERKLVMLNEKYISKKDETLLDAKFDNRVFLLYYYPGLDRDFLEQMLTNTKIRGIIIAGTGLGHTSSDHIELFRKATKDGIFIGMTTQCLFGRVNMNVYTTGRQLLDAGVTPLEDMLPEVALVKLMWVLAHEQDLEKIQNLMITNLVGEINPRHTLDLFPRWSYE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit D, Glu-ADT subunit D.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family. GatD subfamily.
Protein: PYRI_PHOLL
Sequence: MTQDHKLQVEAIRCGTVIDHIPAQVGFKLLSLFKLTETDQRITIGLNLPSNRLGKKDLIKIENTFLTEQQANQLAMYAPNATVNCIENYEVVKKLPINLPKCIDNVLVCPNSNCISHNEPVESSFRVKVTVEDVVLTCKYCEKEFDRNVVILND
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: NUOD1_CHLT3
Sequence: MKTRDEKITVSDGLERLPEPALKSDERKMARQKIYALLEDRDATLTFEEDDPLEQTMVLNMGPQHPATHGVLRVVLKLDGERVVHAVPELGYLHRAMEKLAENKSYHEFMPYTDRLDYMSPYSNNTALCLAVEKLAEIEVPERATYIRTIACELARISSHLLSIGALVMDTGALSVFLWTFQEREKIYDIFDLLTGARFTISHCRVGGIASDLSKECAELIIRWLKQFKPKIQEWRKLLDRNRIFIERLEGVGVISKEDAIAIGLSGPNLRASGVHYDIRRDEPYLAYNDLDFEIPTFENGDSYARYQMRMLEMEESVKIIEQALRKLPKGEVRNEDAKKTFPWKDEIYHSMESLIHDFMMTDSGIQMPKGEIYHAIEAPKGELGFYIQSRGEGVPWRLKIRSPSFCNLQALPKLVEGGMIADVVIIIGSLDPVMGEADK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D 1, NADH dehydrogenase I subunit D 1, NDH-1 subunit D 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MUTS_PSEPK
Sequence: MSDLSAHTPMMQQYWKLKNQHPDQLMFYRMGDFYEIFYEDAKKAAKLLDITLTARGQSAGQSIPMCGIPFHSLEGYLAKLVKLGESVVICEQIGDPATSKGPVERQVVRIITPGTVSDEALLDERRDNLIAALLGDERLFGLAVLDITSGNFSVQEIKGWENLLAELERLNPVELLIPDDWPRDLPAEKRPGARRRAPWDFDRDSARKALCQQFATKDLKGFGCDKLTLAIGAAGCLLTYAKETQRTALPHLRSLRHERLDDTVILDGASRRNLELDINLAGGRDNTLQSVIDRCQTAMASRLLSRWLNRPLRDLKVLQARQDSIRCLLDSYRFEKLQPQLKEIGDIERILARIGLRNARPRDLARLRDALGALPELQNAMTELEAPHLARLAAITGTYPELASLLERAIIDNPPAVIRDGGVLKAGYDNELDELLAISENAGQFLIDLEAREKARTGLANLKVGYNRVHGYFIELPTKQAEQAPGDYIRRQTLKGAERFITPELKAFEDKALSAKSRALAREKMLYDALLETLISHLAPLQDSAAALAELDVLSNLAERALNLDLNCPRFVDEPCLRIEQGRHPVVEQVLTTPFVANDLGLDNSTRMLIITGPNMGGKSTYMRQTALIVLLAHIGSFVPAASCELSLVDRIFTRIGSSDDLAGGRSTFMVEMSETANILHNATDRSLVLMDEVGRGTSTFDGLSLAWAAAERLAQLRAYTLFATHYFELTVLPESEPLVANVHLNATEHNERIVFLHHVLPGPASQSYGLAVAQLAGVPTAVIQRAREHLGRLETTSLPHEQPAAHKAKDAPQVPHQSDLFASLPHPAIEKLGKLQLDDMTPRQAIEMLYQLKNLL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: DNAA_CAMJE
Sequence: MNPSQILENLKKELSENEYENYLSNLKFNEKQSKADLLVFNAPNELMAKFIQTKYGKKIAHFYEVQSGNKAIINIQAQSAKQSNKSTKIDIAHIKAQSTILNPSFTFESFVVGDSNKYAYGACKAIAHKDKLGKLYNPIFVYGPTGLGKTHLLQAVGNASLEMGKKVIYATSENFINDFTSNLKNGSLDKFHEKYRNCDVLLIDDVQFLGKTDKIQEEFFFIFNEIKNNDGQIIMTSDNPPNMLKGITERLKSRFAHGIIADITPPQLDTKIAIIRKKCEFNDINLSNDIINYIATSLGDNIREIEGIIISLNAYATILGQEITLELAKSVMKDHIKEKKENITIDDILSLVCKEFNIKPSDVKSNKKTQNIVTARRIVIYLARALTALTMPQLANYFEMKDHTAISHNVKKITEMIENDASLKAKIEELKNKILVKSQS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_BACVZ
Sequence: MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQREMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDVIGLDASDAVLASAKAGIGIEDILEQIVEKVPAPAGDPEAPLKALIFDSLYDAYRGVVAYIRVVEGTVKPGQKIKMMATGKEFEVIEVGVFTPKAQPADELTVGDVGYLTAAIKNVGDTRVGDTITSAVKPAAEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSLQYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFKIDLITTAPSVIYDVYMTDGEKIIVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRVSIVYEMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSFIVHRDYAYERGKVIVEKLKELIPRQHFEVPIQAAIGQKIVARSTIKAMRKNVLAKCYGGDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SUCC_SHEPW
Sequence: MNLHEYQAKSLFAEYGLPVSEGFACDTAQEAVEAAGHIGGDMWVVKCQVHAGGRGKAGGVKVTGDKEEIRAFAENWLGKNLVTYQTDEKGQPVAKILVESCTDIANELYLGAVVDRATQRVVFMASTEGGVEIETVAEETPELIHKAIIDPLTGPQPYQARDLGFKLGLTPTQMKQFTKVFMGLAKMFEDHDFALLEINPLVITDEGNIHCLDGKIGIDGNALFRQPKIREMHDPSQDDAREAHAAKFELNYVALDGNVGCMVNGAGLAMGTMDIVNLHGGKPANFLDVGGGATKERVAEAFKIILSDSNVKAVLVNIFGGIVRCDMIAEGIIGAVKEVGVEVPVVVRLEGTNADLGREVLANSDLDIIAATSLTDAAEQVVKAAESK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: CEP43_RAT
Sequence: MAATTAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFHPETSTIQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTSVEGALDLSDGHPPSKSPEGKTSVNSTPSKIPRYKGQGKKKTSGQKSGDKKTSSETSQSEPSVSLSESKSKSSLHSLVHETRIASFLSNSTVDAKDKSALCPDEDDVEGDSFFDDPIPKPEKTYGWRSEPRKQVGGLASLSDKPHLRSGLSSLAGAPSLTDAESKRGSTVLKDLKLVGEKIGSLGLGSGEDEDYVDDFNSASHRSEKSELSIGEEIEEDLSMGVEDVNTSDKLDDLTQDLTVSQLSDVADYLEDVA
What is the function of this protein?
Required for anchoring microtubules to the centrosomes.  Required for ciliation.
What are the official names of this protein?
Centrosomal protein 43, FGFR1 oncogene partner.
What is the protein family that this protein belongs to?
Belongs to the CEP43 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Associated with gamma- tubulin. Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole. Localizes to the distal end of the centriole partly to the subdistal appendage region.
Protein: NDUF4_DROME
Sequence: MGQVVSMVARRANRFNVENRAHRVLEREKPTPAPKFDSNLRDMERTLELDPKFVDKLNMKDSSLDGRLKDVYVTSQDRFIKRVQERQAAEAAADNVEQRPLPLERKTPDDFEYGYLEPNRISPGHCTLRQALKFINDHQLDPESWPAKKIANEYKLKEPLVENILHYFKTFNMYIPDQKYKDTMLTQATQPLLRVKSSSEGNP
What are the official names of this protein?
Protein NDUFAF4 homolog.
What is the protein family that this protein belongs to?
Belongs to the NDUFAF4 family.
Protein: IF2_CHLMU
Sequence: MEHAKLTKNLKLKIKNAQLTKAAGLDKLKQKLAQAGSSDTKNSPVSKAQTKEKSSKKTAGTTASAPEIESGATESTARRIRAKDRSSFAAEEPSTTVALPGDASHLTLDALPSADSTEPLSNSSQEKIVEDAVETPNSPQEDGKELQEEVANEQPARNEETPIIRTRTEPKSVVSIKPKFGPTGKHINHLLAKTFKAPAKETKAAAPAEETTQQTRPSVETASTKQQQPSGTNTRPAQSAPAYRRESTNNNNNSKRGPDRDRTKRSDENVKAFTGRDRYGLNEGSSEEDKWRKKRVHKTKKQSEEHVVQCPSHIKIALPITVKDLAAEMKLKASELIQKLFIHGMTYVVNDVLDSQTVVQYIGLEFGCTIEIDSSEKEKLCLVENTVRDEINETNPQKLVIRSPIVAFMGHVDHGKTTLIDALRQSNMAASEAGAITQHMGAFKCSTPVGEITVLDTPGHEAFSAMRARGAEVCDIVVLVVAGDEGIKEQTVEAIEHAKAANITIVVAINKCDKPNFNEETVYRQLAELNLLPEAWGGSIATINTSAKTGEGLQDLLEMLALQAEVLELKADPSARARGLVIESELHKGLGAVATVLVQNGTLHLGEALVFNDCYGKIKTMHNEHNQLLQSASPSTPVLITGLSAIPKAGDPFIVVKNEKVAKEIISARLAGQQRSAALQKKRPNFDAVLQNKKTLKLIIKADVQGSIEALAHSILNIRSEKVDVEILSSGVGDISESDIRLASASKATVIGFHTSVESHAESLIKSLNVKVCLFDIIYHAVDAIKEIMTGLLDPIAEEKNLGAAEIKATFKSSQLGTIYGCLVTEGTMVRNQKVRIIRDKEVLWKCSLSSLKRLKEDVKEVKKGMECGILLDNYQQAQIGDTLQCYEVIYHPQKL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4395_PSEAE
Sequence: MPSFDVVSELDKHELTNAVDNAIKELDRRFDLKGKCSFEAKDKSVTLTAEADFMLEQMLDILRSNLVKRKVDSQCMEIKDAYPSGKVVKQDVNFREGIDKDLAKKIVGLIKERKLKVQAAIQGEQVRVTGKKRDDLQEAIALLRGESLGMPLQFTNFRD
What are the official names of this protein?
UPF0234 protein PA4395.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: PUR9_BAUCH
Sequence: MQRPIIIRRALLSVSDKTNICELAKSLLKRGVQLISTNGTARLLVNAGIHVTEVSNYTGFPEIMDGRVKTLHPKIHGGILARRNIDDTIMQQYKIEHIDMVVVNLYPFAEVVASATCNHEKVVENIDIGGTALLRSAAKNYSNVVVVVSINDYISIINEIDCNNGAVSLETRLNLAIKAFQHTATYDSQIKDYFTSQVYTDSSKCSSIFPPILNINFVKKQDMRYGENQHQLAAFYLDTRNKEKSIATTKQLQGRALSYNNIADADAALECVKEFSEPACVIVKHINPCSVAMGKTILVAYQRAYETDPTSAFGGVIAFNRSLDLCTAQEIIARQFIEVIIAPTVDQEALLILAKKKNIRVLSSGQWNKPIPNLNFRQVNGGLLVQERDLVMINLHDLRIVSQRQPTTMEIQDALFCWKVVKFVKSNAIVYARNQRTIGIGAGQMSRIDSAKIASIKAIDNKLNIRGSTMASDAFFPFRDGLDSAAKVGVSCVIQPGGSIRDQEVITAANEHNIAMIFTNIRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.