PharMolix/UniProtQA huggingface dataset:
Protein: CTAA_RHOPS
Sequence: MTAAAELRPRRVRPVRIWLTLVAMLIAVMVLVGGATRLTESGLSIVEWKPVTGTLPPLNDAQWRDAFEGYKTIPQYRELNAGMTLGEFKTIFWWEWGHRLLGRVIGIAYLLPLLWFLWRGAIAPEWKRALWAIFALGALQGAVGWWMVASGLSQRTEVSQVRLAIHLTLALVIYAAIVWTLRRLAGRPPIVAAARLKFTAIALLALTLVQLFLGALVAGLRAGRMFNTWPLIDGALIPEASRLWFEQPWWKNLFDNHLTVQFDHRMMAYALWALAAWHAIDALRARAGGAAGGALWLFAALSLQAVLGILTLLYQVPIGLALAHQAVGIVVLTLAVLQVERLTASKSKEAPRVMPAPASQRG
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SL9A9_HORSE
Sequence: MERQRRFMSEKDEYQFQHQGAVELLVFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIESGTVYDCGKLAFSPSTLLINITDQVYEYKYKREISQHNINPHLGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMVYAGQLKNGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDAAAFFQSVGNFLGIFAGSFAMGSAYAVVTALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNNLSLDSKMRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFVARACNIYPLSFLLNLGRKHKIPWNFQHMMMFSGLRGAIAFALAIRDTESQPKQMMFSTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDEDLKERPSSHQEANNLEKSTTKTESAWLFRMWYGFDHKYLKPILTHSGPPLTTTLPEWCGPISRLLTSPQAYGEQLKEDDAECIVNQDELAMNYQEQAASPCSPPTRLGLDQKAAPQTPGKENIYEGDLGLGGYELKLEQTPGQSQLN
What is the function of this protein?
Endosomal Na(+), K(+)/H(+) antiporter.  Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (PubMed:33118634).  By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification.  Regulates organellar pH and consequently, endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters (By similarity).  Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (By similarity).  Regulates synaptic transmission by regulating the luminal pH of axonal endosomes.  Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages.  Can also be active at the cell surface of specialized cells, e. g. , in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH (By similarity).
What are the official names of this protein?
Sodium/hydrogen exchanger 9, Na(+)/H(+) exchanger 9, NHE-9, Sodium/hydrogen exchanger, Solute carrier family 9 member 9.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Protein: GSH1_CROS8
Sequence: MIPDVSQALAWLTEHPEALKGIRRGLERETLRVTPEGELATTGHPESLGAALTHKWITTDFAEALLEFITPVDGDIDHMLTVMRDIHRHTARALGDERMWPLSMPCYIKEGQDIELAQYGTSNIGRFKTLYRSGLKNRYGALMQTISGVHYNFSLPLAFWQAKCQVDDAESGKEAISAGYFRLIRNYYRFGWVIPYLFGASPAICSSFLQGKPTKLPFEKTDCGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLHGYVAGLKRAIKTPSEEYAKLGLKKDGEYLQINTNILQIENELYAPIRPKRVTRDGESPSDALLRGGIEYIEVRSLDINPFSPIGVDENQVRFLDLFMVWCALADAPEMSSDELLCTRTNWNRVILEGRKPGLTLGIGCETAQFPLEKVGKDLFRDLRRVAQTLDGIHGGQEYQQVCDRLVACFDDPELTYSAQILRSMIENGIGGTGRMLADRYRTMLREEPLQALHEEDFRQEQAASLARQREIEAADTEPFDEWLAKQA
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: GLMS_PYRAE
Sequence: MCGIFGIIFAERPRRPLGEILRRGLERLEYRGYDSAGVAVVDRGLVVKKDAGKVAEVAQRYGFDSLQGVVGLAHTRWATHGKPDQVNAHPHVDCRGVIAVVHNGIIEKYAELKEELMKRGHVFRSETDTEVIAHLVEEYKKQGLDTFSAFKKALSRVRGAYAIALIDAENPRAIYFARNLSPLIIGVGEGFNIVASDIPTVLDHTKRVIAVRDGEYGYITAGEVYIEADGVPQDVAARIEEIPWSAEMATKGGYPHFMLKEIYEQPESLASTAAGLEPAQIETVANALLAARNVYIVGAGTSYHAGLTLAFILPRLRITPIPVISSEYAIYEDLYDKDDLAIAISQSGETIDTIKAVKAMRERGVKVVAVTNVVGSTLSRESDVVLYTRAGPEIGVAATKTFTTQVLTLAAVYLTALRALGHDVAEHQRELKAVPDLARKTIEKTAGTAKELAKRLRQRHSAYYLGRGAALPVAMEGALKLKEVAYLHAEAYPAGESKHGPIALVEEGFPVIFVFSDPNTGEKTLSNVAEMKARGALTIGTVPARSDYAKKLDVAIEVPQTSELFAPILHVIPLQMLAYFTAVERGYDPDKPRNLAKTVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_CAEBR
Sequence: MNNFFQGYNLLFQHSLFASYMDWFHAFNCSLLLGVLVFVTLLFGYLIFSTFYFKSKKIEYQFGELLCSIFPTIILLMQMVPSLSLLYYYGLMNLDSNLTVKVTGHQWYWSYEYSDIPGLEFDSYMKSLDQLNLGEPRLLEVDNRCVIPCDTNIRFCITSADVIHAWALNSLSVKLDAMSGILSTFSYSFPMVGVFYGQCSEICGANHSFMPIALEVTLLDNFKSWCFGTME
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ML329_ARATH
Sequence: MATSGTYVTEVPLKGSADKHYKRWRDENHLFPDAIGHHIQGVTVHDGEWDSHEAIKIWNYTCDGKPEVFKERKEIDDENMVITFRGLEGHVMEQLKVYDLIYQFSQKSPDDIVCKITMIWEKRTDDSPEPSNYMKFLKSVVADMDEHVLKA
What are the official names of this protein?
MLP-like protein 329.
What is the protein family that this protein belongs to?
Belongs to the MLP family.
Protein: KDPA_CITK8
Sequence: MAAQGFLLTASFLLILFVLARPLGVGLARLINDIPLPGTASVERLLWRGLGISTQEMDWKQYLLAILTLNLLGLTVLFLMLLGQNLLPLNPQQLPGLSWHLALNTAISFVTNTNWQSYGGETTLSYFSQMAGLTVQNFLSAATGIAVIFALIRAFTRQNIDTLGNAWMDLVRITLWILLPLALLIALLFIQQGALQNLLPYQSFTSVEGVKQLLPMGPVASQEAIKMLGTNGGGFFNANSSHPFENPSALTNMVQMLAIFLIPAALCFAFGDASGDRRQGQMLLWAMSIIFVVCVAVVMSAEVQGNPHLLKFGTDSSLNMEGKESRFGVLVSSLFAVVTTAASCGAVIAMHDSFTALGGMVPMWLMQIGEVVFGGVGSGLYGMLLFVLLAVFIAGLMIGRTPEYLGKKIDVREMKMTALAILITPTLVLLGTALAMMTETGRSGMLNPGPHGFSEVLYAVSSAANNNGSAFAGLNANTPFWNCLLAFCMFVGRFGVIIPVMAIAGSLVGKKRQPASPGTLPTHGALFVGLLIGTVLLVGALTFIPALALGPVAEHLSLY
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: INO1_PLAF7
Sequence: METYKGIQFFSNKGTVKNAFKKSNLGYEVMLDRKEDENFIYSNYEHVETQVEKDSKGMVVCKKYKNTYEILVEKVKEKRLGVLLVGIGGNNATTMLGGICANAKDLSYMNKCDLKRSNYLGSVFLSSNIRLGYNEKDKEHAYAPIYKLIDIYNPENIVYGGWDINNMNLKDCLVRNKVFDNEVIEKIKDDLDYVPLKSVYFKGNFIAGNQQRRVNNILYGKNKLEILEQVREQIRNFKKQNNLNELIVLWSGNTEKNIPHIPGVNDTFLNILHACKKNHESVSPSVIYALAAILENSPFINSSPQNTLVSAVVQLAQQKGIFIIGNDLKTGQTKIKNFLLDFYFGTGLKPKSIVSYNHLGNNDGKNLSSDLQFYSKKVSKSNLICDYVRANENLYVDDEKDTNVLVKKSIDYCEGDSLNEKGKVSADIEDDCTYVESLEKQKVNSEIVIKYVPYVGDDKKAIDEYISEIFMNGKNTIVLYNICQDSMLASPILIDLILLVELSQRVFFKPNQEKKTNEDEHLLNENIQIEDYKLSHTILKPKYSSFKNLDSVLFLSSLFCKSPFNSTVYKTRHSFFSQLESLWNFVRIISGLPIDAHIDLPYMI
What is the function of this protein?
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (By similarity).  Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).  De novo-synthesized myo-inositol is essential for incorporation into GPI (glycosylphosphatidylinositol) glycolipids during intra-erythrocytic development (PubMed:24350823).
What are the official names of this protein?
Inositol-3-phosphate synthase 1, IPS 1, Myo-inositol 1-phosphate synthase, MI-1-P synthase, MIP synthase, MIPS.
What is the protein family that this protein belongs to?
Belongs to the myo-inositol 1-phosphate synthase family.
Protein: SSPN_MOUSE
Sequence: MGRKPSPRAQELPEEEARTCCGCRFPLLLALLQLALGIAVTVLGFLMASISPSLLVRDTPFWAGSIVCVVAYLGLFMLCVSYQVDERTCVQFSMKVFYFLLSALGLMVCMLAVAFAAHHYSLLAQFTCETSLDSCQCKLPSSEPLSRAFVYRDVTDCTSVTGTFKLFLIIQMVLNLVCGLVCLLACFVMWKHRYQVFYVGVGLRSLMASDGQLPKA
What is the function of this protein?
Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix.  Preferentially associates with the sarcoglycan subcomplex of the DGC (By similarity).
What are the official names of this protein?
Sarcospan, K-ras oncogene-associated protein, Kirsten-Ras-associated protein.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions.
Protein: HIS7_PEA
Sequence: MELYAASHSLPNYPSSFLFKPKITTFHTTLFPTKFAPFKASFFSPNHLTLTTPMNPPTTSLSSAAFVEHNNGSTSTSLPFHPETRVGEVKRVTKETNVSVKINLDGSGVADSSTGIPFLDHMLDQLASHGLFDVHVKATGDVHIDDHHTNEDVALAIGTALLQALGDRKGINRFGDFSAPLDEALIHVSLDLSGRPHLSYNLDIPTQRVGTYDTQVVEHFLQSIVNTSGMTLHIRQLAGRNSHHIIEATFKAFARALRQATEYDPRRRGSVPSSKGVLSRS
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, chloroplastic, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRUB_BURP0
Sequence: MARRALDGVLLLDKPVGLSSNDALMRAKRLYQAKKAGHTGTLDPLASGLLPLCFGEATKFSQDLLEADKTYEATMRLGVRTTTGDAEGDVLDTRDVSCDEAAVRAALARFVGEIVQVPPMYSALKRDGKPLYEYARAGQTVEREGRTVTIRALALVSCALPDVTFRVTCSKGTYVRTLAEDIGEALGCGAHLTMLRRTGVGPLTLEHAVTLDALDAATQDERDARLAPVDALLSTFPCVKLDAALATRFLHGQRLKLSELAARPDAAEGGRVRVYDADDRLLGVARASEGVLAPERLVVTGA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RAA2A_ARATH
Sequence: MARRPDEEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFCLESKSTIGVEFATRTLQVEGRTVKAQIWDTAGQERYRAITSAYYRGALGALLVYDVTKPTTFENVSRWLKELRDHADSNIVIMLIGNKTDLKHLRAVATEDAQSYAEKEGLSFIETSALEALNVEKAFQTILSEVYRIISKKSISSDQTTANANIKEGQTIDVAATSESNAKKPCCSSS
What is the function of this protein?
Intracellular vesicle trafficking and protein transport.
What are the official names of this protein?
Ras-related protein RABA2a, AtRABA2a, Ras-related protein Rab11C, AtRab11C.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Endosome membrane. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Note=During cytokinesis located to the growing margins of the cell plate.
Protein: RL5_PYRAB
Sequence: MAITIPNREEILADWEAHPMRKPRIEKVTINIGVGESGERLTKAEIMLERLTGQKPIRRKAKKTNRDFGIRRGEPIAVKVTLRGPKAYEMLKRLLAAVDNRLKASSFDEHGNVCFGIDEHINIPGVEYDPEIGIFGMDVCVTLERPGFRVARRKRKRAKIPTRHKLTKEEGMVYMMEEFGVEIVEEEG
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RL11_LISMF
Sequence: MAKKVIKEVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNARTADQAGLIIPVVITVFEDRSFTFITKTPPAAVLLKKAAKVEKGSGEPNKTKVASVTRAQVQEIAETKMPDLNAANVESAMLMVEGTARSMGITIQD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: CLPP_DAUCA
Sequence: MPIGVPKVPFRSPGEEDASWVDVYNRLYRERLLFLGQEVDSEISNQLIGLMVYLSIENDTKDLYLFINSPGGWVIPGVAIYDTMQFVRPDVQTICMGLAASMGSFILAGGEITKRLAFPHARVMIHQPASSFYEAQTGEFILEAEELLKLRETLTRVYVQRTDKPLWVVSEDMERDVFMSATEAQAYGIVDLVAVVE
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: COX1_CRAZI
Sequence: MFINRWLFSTNHKDIGTLYMIFGAWAGMVGTGLSILIRAELGQPGSLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLSSSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAITQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTIGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFTGYTLNDTWAKIHFTIMFVGVNMTFFPQHFLGLAGMPRRYSDYPDAYTTWNTISSMGSFISLTAVILMVFIIWEALASKRVVKSIPLTSTNLEWMHGCPPPFHTFEEPAFIKSSIK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DEOC1_YERPS
Sequence: MTTNYAHYIDHTLLAMDATEAQIIKLCEEAKQHHFYAVCVNSGYVPVAAQQLAGSSVKVCSVIGFPLGAGLTAAKAFEAQAAINAGAQEIDMVINVGWLKSGKIADVKADIKAVRDNCAATPLKVILETCLLSDEQIVQVCEMCRELDVAFVKTSTGFSTGGAKEEHVKLMRATVGPVMGVKASGAVRDRATAETMIQAGATRIGTSSGVAIVSGQQAAASGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase 1, DERA 1, 2-deoxy-D-ribose 5-phosphate aldolase 1, Phosphodeoxyriboaldolase 1, Deoxyriboaldolase 1.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALM_CHLRE
Sequence: MAANTEQLTEEQIAEFKEAFALFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMISEVDADGNGTIDFPEFLMLMARKMKETDHEDELREAFKVFDKDGNGFISAAELRHVMTNLGEKLSEEEVDEMIREADVDGDGQVNYEEFVRMMTSGATDDKDKKGHK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: F175B_CAMFO
Sequence: MADSDLLVTISGAALSLLFFENVRSVGNQMGFLLGEALEFIVKTYTDSDNQVETVKIHINVEAIVTCPLADLLHDSTNHINKEKLKDFVRDKSKQVIGWFCFRRNTTNLTLTLKDKLLHKQFASHFSGVNGCKEDFFLTCLLNASTSETSGTHKFRHVFLRHNKRGMFEPISLKINNLGDDASRHDGSDYKPTPVRKSTRTPDSFTKLIESLNLDVARIDGLDSAMLIQKAAEHHLMSLIPKVCESDLEVAELEKQVHELKIKIATQQLAKRLKINGENCDRISKASKDNCFSEKIDSSKKNEVRIGDDACLQREHIPSCTQSVGPNNRTVCRNTAACIAKSAEKSRRAGRSNLQESGNQQQETQNFFTNSRRSIPEIATESICQEGSEISMGRGRGSGRGSHEFTPGMKKIRRTPGTSHMHSSRERSTTPPEQDFSDAECPISSPVLRSYSQVTKKTNLDKCNSMAPLDI
What is the function of this protein?
Component of the BRISC complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:26344097).  Does not have activity by itself, but the catalytic subunit BRCC3/BRCC36 needs to be associated into a heterotetramer with FAM175B for minimal in vitro activity (PubMed:26344097).  May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity).  Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity).  Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1 (By similarity).
What are the official names of this protein?
BRISC complex subunit FAM175B, BRISC complex subunit KIAA0157 homolog.
What is the protein family that this protein belongs to?
Belongs to the FAM175 family. Abro1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=A minor proportion is detected in the nucleus. Translocates into the nucleus in response to DNA damage. Directly binds to microtubules and is detected at the minus end of K- fibers.
Protein: NGFV_MACLB
Sequence: MSMLCYTLIIAFLIGIWAAPKSEDNVSLGSPATPDLSDTSCAKTHEALKTSRNTDQHYPAPKKAEDQEFGSAANIIVDPKLFQKRRFQSPRVLFSTQPPPLSRDEQSVEFLDNADSLNRNIRAKRATHPVHNRGEFSVCDSVSVWVANKTTATDIRGNVVTVMVDVKLNNNVYRQYFFETKCKNPSPVSSGCRGIDAKHWNSYCTTTDTFVRALTMEGNQASWRFIRIDTACVCVISRKNDNFG
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).  It promotes neurite outgrowth in rat PC12 pheochromocytoma cells (PubMed:19463841).
What are the official names of this protein?
Venom nerve growth factor, v-NGF, vNGF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: LIPA_BEII9
Sequence: MPPLADASTETLSPAEQAAVRHPEKAHRPDQPIARKPDWIRVKAPGSPEWVETQKIVKEHKLVTVCEEAGCPNIGECWAKKHATFMIMGDTCTRACAFCNVKTGLPNGLDPHEPAHIADAVQKLGLSHVVITSVDRDDLADGGAEHFAQVIRAIREASPKTTIEVLTPDFLRKDGALEIVVAARPDVFNHNLETVPAKYLSVRPGARYFHSIRLLQRVKELDPTIFTKSGIMVGLGETRNEVLQLMDDLRTADVDFLTIGQYLQPTRKHHAVEAFITPDEFAAYAEVANAKGFLLVSASPLTRSSHHAGEDFARLKAARLERLGR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_NOCSJ
Sequence: MTLPGPEAPGLSEALALIADVPDFPQPGILFKDITPLLAEHAALEAVVAALAAPGRDQTGAPVVDKVLGMESRGFILGAPVALALGVGFVPVRKAGKLPRATYAVSYALEYGEATLEVHQDALEPGDRVLLVDDVLATGGTARATIDLVEKCGASVHAVAILMELGFLPGREALGTVPLTTLLTV
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.