PharMolix/UniProtQA huggingface dataset:
Protein: RUVA_SALRD
Sequence: MIDYVSGTLVDKTTDSALVDVNGLGYRVHVPTSTYKRLPDTDEEVTLHTYHYLREDDESLYGFATKAERTVFETMTGVSRVGPKLALSALSAMTPTELRDHVMEGDKSRLTQISGVGTKTADRLIVELRDRLADLDVLEDTSPLSGGSDARAEARADALEALTELGLSKADAERSIRQVLRDNAGIQSADELVRRALKADQE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: EMC4_YEAST
Sequence: MSEQEPYEWAKHLLDTKYIEKYNIQNSNTLPSPPGFEGNSSKGNVTRKQQDATSQTTSLAQKNQITVLQVQKAWQIALQPAKSIPMNIFMSYMSGTSLQIIPIMTALMLLSGPIKAIFSTRSAFKPVLGNKATQSQVQTAMFMYIVFQGVLMYIGYRKLNSMGLIPNAKGDWLPWERIAHYNNGLQWFSD
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151).  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151).  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151).  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
What are the official names of this protein?
ER membrane protein complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the EMC4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TRUD_CITK8
Sequence: MTEFENLTYLHGKPQGAGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQIEGCKVLEYARHKRKLRLGALKGNAFTLVLREVSHRDDVEARLQAINTRGVPNYFGAQRFGIGGSNLQGALRWAQSNAPVRDRNKRSFWLSAARSALFNQIVNERVKKPDFNQVVDGDALQLAGRGSWFVATQEEQAELQRRVDEKELMITAALPGSGEWGTLRDALAFEEAAIADEGELQSLLLREKVEAARRAMLLYPQQLRWNWWDDVTVELRFWLPAGSFATSVVRELINTMGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: DPO3A_RICBR
Sequence: MQTEFIHLRTQSSYSFLASALTTEKIVELASSYKMAAICLTDKENLFGSLEFALYAIKKGLQPIHGVILNIQYETGVFAEILLIAKDETGYKNLLKLSSITFTTNDRKICNHITFEDLKEHQEGLITLCCYTEGVIGKCLLANKEEQAEMFARNLQEIFGDRFYFEIMRHDLPEEQLIEDNYIKIASKLNIPLVATNKVLFSKKSMHDAHDVLLCISAGVTKEYPDRKTVSENCYFKSAKEMIELFADLPSAIENTVNLTQRCYFAAHTNPPMLPNFATKDISETDLIRKEAKDGLLARLDTKFKSEHISIEHQESIKTEYFARLDYELNIICSMNFAGYFLIVSDFIKWSKKQGILVGPGRGSGAGSVVAWSLLITDLDPIKFGLLFERFLNPDRISMPDFDIDFCQERREEVINYVRSKYGNNRVGQIITFGKMQAKAVIKDVARVLSLPYKFADYLTELVPFSAINPVTLEQAIREVPELANAAKGNGLYNLEGELELIKLVLDTSLILEGLHRHSSTHAAGIVIAGTDLVDIVPVYKDANSDMLVVGYSMKYCELAGLIKFDFLGLQTLTVITDCKKLLKEQNIEIDFNDMTFDDEKTYQMLCKGKGVGVFQFESVGMKDALRRLKPDSIHDLIALGALYRPGPMENIPTYIACKHKLQQPDYLHELLKPILEETYGVVIYQEQVQRIAQVLAGYTLGAADLLRRAMGKKIKAEMEQQEEIFVKGAIANNISEAQAKSIFATVAKFAGYGFNKAHAAAYGVISYQTAYLKANYPAEFVVACLNLELNNHDKINLFLQEAKDNNIKIIAPNINISGGYFSVKSVIPRLDCGIHGDQLKDTAVKPQYDIDSSIIFALGAIKGVTPNFGKLVTDERNARGAFKSIVDFIERLPPKAINSKLLENLIKAGCFDELHDNRLQLFLSISKLLAYSVSYHEEQASNQFSLIKVSSLSKEILVSSDYADKNTLAFYEFEAMGLFISNHPLTEYKEIFNRLNILSSADLHNNLPDGTNRVMIAGVIQKKDSRMSARGRFVTLVLSDPENIFELSIFSEEVLKDYVHLLDVKSLVVVNCDIIKDEGGIKITAKSFSSIENATGNQQFDLQLYPKNDEELEQIITLLSARINNDEQSNTIATIYLSNKSVKNFVAKITFPEKFFLKGQDFEILSIYQNT
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The alpha chain is the DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase III subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_BARHE
Sequence: MEIVDTRTPNSKRFISGVTGDWEVIIGMEVHAQIISNSKLFSGASTKFGAEPNNHVSLIDAAMPGMLPVLNQECVRQAVRTGLGLKARINLRSVFDRKNYFYPDLPQGYQISQFRYPIVGEGKIIISIGPDSNGQFEDIEVGIERLHLEQDAGKSMHDQHPTMSFVDLNRSGVALMEIVSKPDMRSADEAKAYMTKLRTIVRYLGTCDGNMDEGSMRADVNVSVRRPGESFGTRCEIKNVNSIRFIGQAIEYEARRQIAILEDGGVIDQETRLFDAAKGETRSMRSKEEAHDYRYFPDPDLLPLEFDQAFVDALAAELPELPDDIKIRFINEMGLTAYDASILVTEKAIANYFEKVAHGRDGKTVANWVINDLLGALNKDNREIEETPVSPDQLGSIIDLIKEGTISGKIAKDLFEIIWHEGGDPRQIVEERNMKQVTDTKAIERAVDEIMANNSDKVAQAKQKPALAGWFVGQVMKTTGGKANPQTVNELVKLKLGID
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: PSTB1_YERPE
Sequence: MGLLTPNSLPLLDVQHLTDEQTALAVERLNLFYGDKQVLHDISFCVPKHRVTALIGPSGCGKSTLLRCFNRMNDLLDNCHFDGEIRLGDEIITDKTTDVAALRRRVGMVFQRPNPFPKSIYENVVYGLRLQGVRDRRVLDEAVERSLRAAALWHEVKDRLRENAFRLSSGQQQRLVIARAIAIEPEVLLLDEPTSALDPISTLTIEELITTLKQQYTVVLVTHNMQQAARVSDYTAFIHQGRLVEYNNTDALFTSPYQRQTEDYITGRYG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-specific transport component 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: THGA_ECOLI
Sequence: MNMPMTERIRAGKLFTDMCEGLPEKRLRGKTLMYEFNHSHPSEVEKRESLIKEMFATVGENAWVEPPVYFSYGSNIHIGRNFYANFNLTIVDDYTVTIGDNVLIAPNVTLSVTGHPVHHELRKNGEMYSFPITIGNNVWIGSHVVINPGVTIGDNSVIGAGSIVTKDIPPNVVAAGVPCRVIREINDRDKHYYFKDYKVESSV
What is the function of this protein?
Catalyzes the CoA-dependent transfer of an acetyl group to the 6-O-methyl position of a range of galactosides, glucosides, and lactosides (PubMed:14009486, PubMed:4630409, PubMed:7592843).  May assist cellular detoxification by acetylating non-metabolizable pyranosides, thereby preventing their reentry into the cell (Probable).
What are the official names of this protein?
Galactoside O-acetyltransferase, GAT, Acetyl-CoA:galactoside 6-O-acetyltransferase, Thiogalactoside acetyltransferase, Thiogalactoside transacetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_CHLCH
Sequence: MSKEKIAIAYSGGLDTSVMIKWLKDKYDADIVAVTGNLGQQKEIENLESKALATGASSFHFVDLRTEFVEEYIWRALKAGALYEDVYPLATALGRPLLAKALVDVAVAENCTMLAHGCTGKGNDQVRFEVTFASLAPHMKILAPLRVWEFTSREAEIAYAMEHNIPVSATKKNPYSVDENIWGISIECGVLEDPMIAPPEDAYQITTSPEKAPDTPAVVELEFVEGVPVAMDGKKMNGLDIIVQLNTIGAAHGIGRLDMIENRVVGIKSREIYEAPAATILHFAHRELERLTLEKSVFQYKKNISQDYANIIYNGTWFSPLRTSLDAFVNETQKPVTGLVRLKLYKGNVTLLGRTSPYSLYNEALATYTEADTFNHKAAEGFIHLYGLGLKTFNQIHKG
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP5AC_BACSU
Sequence: MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQNFYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMASAALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS
What are the official names of this protein?
Stage V sporulation protein AC.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RECO_RUEST
Sequence: MDWRDQGILLTVRRHGESSALIEVFTEDHGLHAGLVRGGASRKMAPHLQPGAQLDLTWSARLEDHLGTYKAEPLRSRAGMALSGRLALAGLNAVCALLAFALPDRAPYPALYHRSSALLDLLDSEDLWPLAYLRWELSLLEDLGYGLDLSACAATGVTQDLRYVSPKTGRAVSGAAAGEWADRLLPLPPVMRGEGAAEDIEILTALRTTGFFLESKLAPALGNRPIPEARGRFLDALARRV
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: LPXA_BLOPB
Sequence: MIHQSAIIHPSSIIEEGAIIHDNVHIGPFCFIGAQVEIGARTLLKSHIVINGITQIGEDNQIYQFASLGEVNQDLKYAKESTRIEIGHYNQIRESVTIHRGTIQGKKVTKIGNSNLFMINVHIAHDCIIGDHCVMANNVTLGGHVRVDNHTIIGGMTAIHQFCIIGTHVMIGGCSGVVQDIPPFIIAQGNHATPFGLNIEGLKRRGFSRSSVHAIRDAYKILYRSSKTVESAKEALKALAAEHPIINEFVDFLIRSQRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_POLNA
Sequence: MYSLLETINSPADLRRLPRAQLKALADELRAYVIDSVSQTGGHLSSNLGTVELTVALHYVFNTPDDRLVWDVGHQTYPHKILTGRRERMGTLRQLGGLSGFPRRDESEYDTFGTAHSSTSISAALGMALAAEFKGENRNAVAVIGDGSMSAGMAFEALNNAGVHDHCKLLVVLNDNDMSISPPVGALNRHLAQLMSGRFYASARHVGKKVLQVAPPLLELARRLESHAKGMVVPAAVFESFGFNYIGPIDGHDLESLIPTLENIRHLMATGAGPQFLHVVTKKGQGYKLAEADPIAYHGPGKFDPSMGLQKSSAPAKQTFTQVFGRWLCDMAEHDPRLVGITPAMREGSGMVEFHKRFPKRYHDVGIAEQHAVTFAAGMACEGLKPVLAIYSTFLQRGYDQLIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIPYLRCIPNMGIACPADENECRKLLTTAFEQDSPVAVRYPRGAGAGVEPEAGLKSLPFGKGEIRREGSGIAILAFGTLLYPALQAAEKLGATVVNMRWAKPLDTELLLKVAAGHEVLVTLEEGAIMGGAGSAVGEALQAAGVVKPLLQLGLKDEFIEHGEVAVLLALQGLDAAGIEAAVRSRFGSFKSTDPLAKVMLKSVA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: 3SA3_NAJSP
Sequence: MKTLLLTLVVVTIVCLDLGYTLKCNKLVPLFYKTCPAGKNLCYKMFMVATPKVPVKRGCIDVCPKSSLLVKYVCCNTDRCN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pore in lipid membranes.  In vivo, increases heart rate or kills the animal by cardiac arrest.  In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
What are the official names of this protein?
Cytotoxin 3, Cardiotoxin-3, CTX-3, Ctx3.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: ATPE_FRATM
Sequence: MTKKYLKVDVVSPLGSVFKGEADMVSLRGSAGEMGIAYGHTELLSTLPAGVVNVRKDQHTDVLYVSGGIVEVTPTRVTIMVDDMERAENLNQAEAEKARVRAKEVLKNPDASKLDIEAANKRLKEADARLKALNSSNGLYYSKDD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYH_METFK
Sequence: MSDKFQSIKGFYDILPADTALWQRIEDSARQVLSQYGYRNIRLPIVEPTELFIRGVGEHTDIVEKEMYSWEDKLNGDRLTLRPEGTAGCVRAVVEHSLTYNGPQRLWYMGPMFRHENVQKGRQRQFHQIGAEAFGYTGPDVDAEQISMLARLWRELGVANEVELQLNTIGDASERAQYRQVLIRYFEQHESLLDDDAKRRLYANPLRILDSKNPAMQTMIEAAPKLLDSLGEESRAHFDGVTRQLDQLGIKWTLNTRLVRGLDYYNRTVFEWVTNKLGSQGTIAGGGRYDSLVQSLGGKETPACGFGIGLERVFLLMRECGIEAFHSPDVYLVNVGDAANKAALPIAEALRDSGLSVSLHAGGGSFKSQMKKADQSGAQYALILGDDEIAANEVCLKPLRENGEQRRMSLSQAIEALHT
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_PSESM
Sequence: MAALRLLLGIDYGTKQIGVAVGQAITGQARELCTLKAQNGVPDWDKVQALINEWKPDAIVVGLPLNMDGTPSEMSARAEKFSRKLNGRFGVTVYTHDERLTTFEAKGERMARGGQKGSYRDNPVDAIAAALLLQGWLDEHPELLNV
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSN6B_BRAOL
Sequence: KLHPLVMLNISDHLTKALMDINESPVYVLLNPTINHAQKKMLNSRIRVLHQYLGSMQK
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF.  It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 6b, Signalosome subunit 6b.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CTSR_STAHJ
Sequence: MHNMSDIIEQYIKKLFEESNEDVVEIQRANIAQRFDCVPSQLNYVIKTRFTNEHGYEIESKRGGGGYIRITKIENKDATGYINHLLQIIGPSISQQQAYYILDGLLDKGLISEREARMIQVIVDRETLKMDVVARDIIRANILKRLLPIINFY
What is the function of this protein?
Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region.
What are the official names of this protein?
Transcriptional regulator CtsR.
What is the protein family that this protein belongs to?
Belongs to the CtsR family.
Protein: GCSH_VIBPA
Sequence: MDKTLKFTDSHEWVRDNGDGTVTIGISEHAQEMLGDVVFVDLPDVEDEVEAGESFSLVESVKAASDIYSPVTGEVVEINEELEDSPELINEEPYEGGWIVKVKLSDPSELDDLKDAEEYLSSIEEE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RNH_CHLL2
Sequence: MKKRVTIYTDGACSGNPGRGGWGALMMYGTVNRELSGYEPATTNNRMELTAAIEGLDALKEPCVVDLYSDSAYLVNALNQGWLKRWTTNNWTTSAKKSVENIDLWKKILKLVTLHQVTFHKVKGHSDNPFNNRCDELARQAIKNNS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLDA_ECOL6
Sequence: MDRIIQSPGKYIQGADVINRLGEYLKPLAERWLVVGDKFVLGFAQSTVEKSFKDAGLVVEIAPFGGECSQNEIDRLRGIAETAQCGAILGIGGGKTLDTAKALAHFMGVPVAIAPTIASTDAPCSALSVIYTDEGEFDRYLLLPNNPNMVIVDTKIVAGAPARLLAAGIGDALATWFEARACSRSGATTMAGGKCTQAALALAELCYNTLLEEGEKAMLAAEQHVVTPALERVIEANTYLSGVGFESGGLAAAHAVHNGLTAIPDAHHYYHGEKVAFGTLTQLVLENAPVEEIETVAALSHAVGLPITLAQLDIKEDVPAKMRIVAEAACAEGETIHNMPGGATPDQVYAALLVADQYGQRFLQEWE
What is the function of this protein?
Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone).  Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions.
What are the official names of this protein?
Glycerol dehydrogenase, GDH, GLDH.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family.
Protein: MURD_CUPPJ
Sequence: MFGELQKPHVLVLGLGESGLAMARWCGLNGCAVRVADTREAPANLVFLQAELMSAEFVGGPFAESLLDGIGLVAISPGLSPLEANTGELLAAARQRGIPVWGEIELFARALAHLQAESGYAPKVLAITGTNGKTTTTALTGRLVERAGKSVAVAGNISPSALDKLSACIASATLPDVWVLELSSFQLETTHTLAPHAATVLNVTQDHLDWHGSMEAYAASKARIFGPAGTACVQVLNRNDRLTMDMARPGTAPVTFGTDLPETPGSFGVLREGGMPWLVLAEPDSEAEGEGKPRRRKADATAQEAVPVRHKRLMPADALHIRGMHNATNAMAALALCRAIDLPLNALLHGLREYRGEPHRVEWVATIDEVEYFDDSKGTNVGATVAALSGLDKRVVLIAGGEGKGQDFSPLAAPVAQYARAVVLIGRAAGELRDALQGSGASLVDAATLEEAVNKAAELAEGGDVVLLSPACASLDMFRNYVHRAEVFRSAVEELALSRGIMP
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPP60_RAT
Sequence: MARATGPEQRLLAIYTGGTIGMRSEGGVLVPGRGLAAVLRTLHMLHDEEYARAHSLPEDTLVLPPASSDQRIIYKVLECQPLFDSSDMTITEWVQIAQTIERHYTQYQGFVVIHGTDTMAFAASVLSFMLENLQKPVILTGAQVPIHELWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRTTKVDARRFAAFCSPNLPPLATVGADVTINRELVRKASWKSHLVVHSNMEPDVGLLRLYPGIPASLVRTFLQPPLKGVVMETFGSGNGPTKPDLIQELRAAAERGLIIVNCTHCLQGAVTSDYAPGMAMAGAGIISGFDMTSEAALAKLSYVLGQPGLSLSDRKKLLAKDLRGEMTLPTTDDLLGDDMLGCRATWLLSMNGSQDADAMKDVLLPGLALAAAHAGDLDTLQAFVELGRDLNLKDYSGQTPLHVAARRGHASVVAMLLQKGVDVDACNEDGQSPLLLAVRGRHQSVIRLLRAAGAHLSPQELEDVGTELCRLASRADSEGLRAWWQAGADLGQPDYDGHCALQVAEAAGNADVVALLQSLEDRVSAQPQPH
What is the function of this protein?
Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (PubMed:9575212, PubMed:8119970, PubMed:10320809).  Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (PubMed:10320809).  Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (PubMed:10320809).
What are the official names of this protein?
60 kDa lysophospholipase, Lysophospholipase-transacylase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the asparaginase 1 family.
Protein: FLO11_YEAST
Sequence: MQRPFLLAYLVLSLLFNSALGFPTALVPRGSSEGTSCNSIVNGCPNLDFNWHMDQQNIMQYTLDVTSVSWVQDNTYQITIHVKGKENIDLKYLWSLKIIGVTGPKGTVQLYGYNENTYLIDNPTDFTATFEVYATQDVNSCQVWMPNFQIQFEYLQGSAAQYASSWQWGTTSFDLSTGCNNYDNQGHSQTDFPGFYWNIDCDNNCGGTKSSTTTSSTSESSTTTSSTSESSTTTSSTSESSTTTSSTSESSTSSSTTAPATPTTTSCTKEKPTPPTTTSCTKEKPTPPHHDTTPCTKKKTTTSKTCTKKTTTPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVTSSTTESSSAPVTSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPAPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSTPVTSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPAPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVTSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSSAPVPTPSSSTTESSVAPVPTPSSSSNITSSAPSSTPFSSSTESSSVPVPTPSSSTTESSSAPVSSSTTESSVAPVPTPSSSSNITSSAPSSIPFSSTTESFSTGTTVTPSSSKYPGSQTETSVSSTTETTIVPTKTTTSVTTPSTTTITTTVCSTGTNSAGETTSGCSPKTVTTTVPTTTTTSVTTSSTTTITTTVCSTGTNSAGETTSGCSPKTITTTVPCSTSPSETASESTTTSPTTPVTTVVSTTVVTTEYSTSTKPGGEITTTFVTKNIPTTYLTTIAPTPSVTTVTNFTPTTITTTVCSTGTNSAGETTSGCSPKTVTTTVPCSTGTGEYTTEATTLVTTAVTTTVVTTESSTGTNSAGKTTTGYTTKSVPTTYVTTLAPSAPVTPATNAVPTTITTTECSAATNAAGETTSVCSAKTIVSSASAGENTAPSATTPVTTAIPTTVITTESSVGTNSAGETTTGYTTKSIPTTYITTLIPGSNGAKNYETVATATNPISIKTTSQLATTASASSVAPVVTSPSLTGPLQSASGSAVATYSVPSISSTYQGAANIKVLGNFMWLLLALPVVF
What is the function of this protein?
Homophilic binding protein that enables kin discrimination in heterogeneous yeast populations by mediating homotypic cell-cell interactions during flocculation, a reversible and asexual process in which cells adhere to form aggregates (flocs) (PubMed:32286952, PubMed:25960408, PubMed:27547826, PubMed:17921350, PubMed:22129043).  Plays a role in cell-substrate adhesion, haploid invasive growth, diploid pseudohyphae formation and biofilm (flor) development (PubMed:18001350, PubMed:11027318, PubMed:11157168, PubMed:16043420, PubMed:17921350, PubMed:20619652, PubMed:8710886, PubMed:8955395).  Adhesive activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose (PubMed:16043420, PubMed:22129043).
What are the official names of this protein?
Flocculation protein FLO11, Flo11p, Flocculin-11, Mucin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the flocculin family. Highly divergent.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=The protein is attached to the cell wall via a GPI-anchor and is also shed liberally into extracellular fluid; increased shedding is associated with biofilm mat expansion but decreased invasive growth.