PharMolix/UniProtQA huggingface dataset:
Protein: NPL4_LODEL
Sequence: MSLILRFRSKDGMFRVNTDSSSTFQTVVDQLSLKLPTTDYDQITVSDKPNNKNDLGSQAKTLLSILHQTISELQLKNGDLLFLNYSNAIPQGTLASTSSTKLQSGSIAINSSGGSSGPATASGANASTIRVSPTTHGPVKVSQLPIDDELDSQDGILSRPISSMCRHGAKGMCEYCSPLPPWDENYRKEHAIKHISYHAYLKQQMAKFNKKELSSSYIAPLENPNYAINLNCNEGHQSYPRGICSKCQPLPITLQLQKFRMVDHLEYASHTILNDFINVWRSTGVQRFGYLYGRYEKFDKVPMGIKAVVEAIYEPPQHDELDGLTLLDWEDEPIVDAIAAKLGLQKVGIVFTDLTDSGNRDGTVLCKRHKDSYFLTNLEIIMAAKFQIKNPNITKYANLGEFSSKFVTCVISGGLQGEIEPRSYQVSSSAEGLVKADIITGSTQPSQIYVNGNNDTRYVPDIQYSKINEYGLEVKSNAKPTFPGEFLLVSLTDSFPIDPKPLFTSKISYVIENREFLGHGDIDGLDHLQNLSSVAKFIKLNDSELFDFHWLVHVAKMGILSEEELSLLCKYVKEKKYDDYLQLMESGGWMTFLTILEQST
What is the function of this protein?
Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus.  Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).
What are the official names of this protein?
Nuclear protein localization protein 4.
What is the protein family that this protein belongs to?
Belongs to the NPL4 family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes mainly at the nuclear periphery and the endoplasmic reticulum membrane.
Protein: MIAA_BURM9
Sequence: MSERNAASARTVACLLGPTASGKTAAALALAARRPIEIVSVDSALVYRGMDIGTAKPTRDERAAVPHHLIDIVDPADAYSAAEFRADALRLVAQIAARGRTPLLAGGTMLYYRALTQGLNDLPAADPDVRATLDADAARDGWPALHARLAGIDPATAARLAPNDSQRIQRALEVYLLTGQPMSALLAAPPRDNDAAAGLRFVPVALEPSERAVLHARIAARFDAMLEAGFIDEVERLRRRDDLHLGLPSMRCVGYRQAWEYLDGCTDYRTMRDKGIFATRQLCKRQLTWLRAMPERIVVDCCAPDATVRAVDALERVLDGRAPA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RPOB_SYMTH
Sequence: MPKIVQAGRRQRLSFSRIDEVLEMPNLIELQRNSYQWFLREGLQEMFQDISPIQDFTGNLVLEFIDYSLGEPKYSIEECKERDVTYAAPLRVRVRLINKETGEVKEQEVFMGDFPLMTPTGTFIINGAERVIVSQLVRSPGVYFSEQIDPSGKKLFFATMIPNRGAWLEFESDVNDVIYVRVDRTRKLPATVLLRALGFGSDQEILDAVGDSEYIRRTLEKDSTESEEEALIEIYKRLRPGEPPAADNARQLLETLFFEPKRYDLMHVGRYRLNKKLALKRRIVGTSTVDRVVHPETGEVLAEAGVQIDKRLAEKIDEAGVDALTVRLRDGGIVRVVANGRPDIRVKTIVRQDIVAVINYMVSLFKGLGSVDDIDHLGNRRVRSVGELLQNQFRIGLARMERVIKERMTIQDVDIITPQALINIRPVVAAVKEFFGSSQLSQFMDQTNPLAELTNKRRLSALGPGGLSRERAGYEVRDVHTSHYGRMCPIETPEGPNIGLIGALATFARINEYGFIETPYRKVDQESGRVTDEIVYLTADEEDENIIAQANEPLNPDGTFARDRVTCRYRDEILQVPPSQVDYMDVSPKQVVSIATALIPFLENDDASRALMGSNMQRQAVPLLRTEAPYVGTGMEYRSAWDSGVCVIAENDGVVLRATASEVVVQYDDMQVKKYKLTKFTRSNQGTCMNQKPIVRAGDRVRKGDVIADGPSTDQGELALGRNVLVAYMCYEGYNYEDAIIINERLVREDVFTSIHIEEHECEARDTKLGPEEITRDIPNVGEDVLKDLDERGIIRIGAEVRPGDILVGKVTPKGETELTAEERLLRAIFGEKAREVRDTSLRVPHGESGIVVDVKVFTRENGDELSPGVNELVRVYMAQKRKISQGDKMAGRHGNKGVISVIVPEEDMPFMPDGTPIDIILTPLGVPSRMNIGQIMEIHLGWAAKTLGMYVASPVFDGANEQDIREMLLKAHLPPNGKTVLYDGKTGEPFDNEVTVGYKYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQELLTVKSDDVVGRVKTYEAIVKGENVPEPGVPESFKVLIKELQSLALDVKVLDESGNEIELRELDDEMDLSDRDLEIPTLGGAELAKPAPDAQAGEESGEAGEESEGEPEEEDVEEIDVPLDPEELEKVAGALKNPVRAGRRGAGGGLADDDQEMDEEDLFDEGDEDLADDVGLYRGRSRRLADDFGDEEEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CPAS1_DICDI
Sequence: MEFPTKYVYITSNLDKPKEWFTQSEMSLTTTTDTIQKSFVNNSGSSSSSKGFGEAVLLDILDTAGQEEYSAMRDQYVRTGDCFMIVFSIDSRSSFEEVSQLKQHIERVKDRDDVPIIIVGNKVDLESRRQVSRIEADQLARSLRVPYIETSAKTRSNIEEAFFTLVRHTPRNTVYKVVVMGGGGVGKSAIIIQFIQNHFVEEYDPTIEDSYRKQVTISGLPPIGGSLNKKSSSSSSSSSSSSGKTGLFNKIFSGKDKQPSPQQAASPSTIDRTGQISTNRLEANVLSYSMSNLSKEVPLITGDCVYCQGCNVILSRFSNLVKTGDDSFTWKCEFCKYSNSNILLEQGEIPNKDSVEYVLSSPSTSSTTDGSKREESIIIYCIDVSGSMGITTEVPSLQSEWVNAKKGVKGASSGPSYISRLECVQSSIPTMIDRLSIQYPNKRVVLVTFSDEVMIYTQSNSVDGPIVIAGDKLEDFDQLIEIGRSMTYDKLPTASGSSDFLKAKIKSLEPVQSTALGPALLVSAAIASQKMLSEVVICTDGVPNVGLGAIEDLPLGPAQEFYEKVTKLAQNNKTTINIIGISGSHIDLGVIGKVSEQTNGNITIIHPLELAREIRKLTQNPMIATDVEMSICLHPTLEINKYDSKQGLSRVVKQFPNVNSLTDLTLLYSSRNRPTEFVQIYPFQIQIKYTKLDGVRCLRVVSAQLQATPDFNTSTSNANISILAMAFTQQAAKIAQQQEYMESRLHLKAATKLIRSLCNTDEQWEEFYNFEVLREEMEAPLITCIKNKQQRVEKAATDDEIQVFYKMKNVHKSFVEGGRKKDISRRKGEAEINKQYYNIKFT
What are the official names of this protein?
Circularly permutated Ras protein 1, DdiCPRas1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. CpRas family.
Protein: AAXB_CHLCV
Sequence: MPYGTRYPTLAFHTGGIGESDDGMPPQPFETFCYDSALLQAKIENFNIVPYTSVLPKELFGNIVPVDQCIKFFKHGAVLEVIMAGRGASTSDGTHAIATGVGICWGQDKNGELIGGWAAEYVEFFPTWINDEIAESHAKMWLKKSLQHELDLRSVVKHSEFQYFHNYINIKQKYGFSLTALGFLNFENADPATIK
What is the function of this protein?
Part of the AaxABC system, catalyzes the decarboxylation of L-arginine.  The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response (By similarity).
What are the official names of this protein?
Pyruvoyl-dependent arginine decarboxylase AaxB, PvlArgDC, Biodegradative arginine decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the pyruvoyl-dependent arginine decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDH3_SCHPO
Sequence: MFATRSFCLSSSLFRPAAQLLRPAGRSTLRNVWRRSIATEHLTQTEANSRLASQRVHRPNSPHLTIYEPQLTWYLSSLHRITGCVVAGTLYAFAMGYLVAPLAGYSLDTATISGLIQQVPTWIKVPAKFVISYPLTFHIFNGIRHLIWDTTKELSLKGVYRTGYAVLALSVLTSGYFAMI
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase cytochrome B subunit, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b560 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MURE_BRUSU
Sequence: MKLKEIALFNELASGEAGEVEITGITSDSRAVQRGFLFAALKGVKADGAVFAADAVKRGAVAIIAGKDTAIADAGVPVLHVDDPRHVLAIAAAQFYGKQPEVMVAVTGTSGKTSVASFTRQIWAYAGFPAANIGTTGVFSPTRSDYNSLTTPDPVELHRVLAELTSEGVTHAAMEASSHGLDQRRLDGVRLAAGAFTNLGRDHMDYHATIDEYLGAKMRLFNALLPKGAPAIIFADDQFSAQAIEAATLAGCDVKTVGRKGNFIALKRVEHERFRQHVEVRIGEEIFEIELPLAGDFQVANALVAAGLAMVTGVPAAAAMRALALLKGAPGRLDLVGATEDGAPAYVDYAHKPEALENVLTSVRPFTTGRVIVVFGCGGDRDKGKRPIMGEIASRLADVVIVTDDNPRSEVPAQIRSEIMAAATGATEIGDRREAIFTAVSMMQPGDTLVVAGKGHEEGQIVGNITLPFSDHAEVAAALAARLEEHPK
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_ECO55
Sequence: MASENMTPQDYIGHHLNNLQLDLRTFSLVDPQNPPATFWTINIDSMFFSVVLGLLFLVLFRSVAKKATSGVPGKFQTAIELVIGFVNGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHVLGLPALRVVPSADVNVTLSMALGVFILILFYSIKMKGIGGFTKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COAX_XYLFT
Sequence: MNDWLFDLGNSRFKCASLREGVIGPVTVLPYLTETMDAFALQELPRGRVAYLASVAAPAITTHVLEVLKIHFEKVQVAATVAACAGVRIAYAHPERFGVDRFLALLGSYGEGNVLVVGVGTALTIDLLAANGCHLGGRISASPTLMRQALHARAEQLPLSGGNYLEFAEDTEDALVSGCNGAAVALIERSLYEAHQRLDQSVRLLLHGGGVASLLPWLGDVVHRPKLVLDGLAIWAAVAANV
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED29_BOVIN
Sequence: MAASQQQASATTSTASVSGPGSAGGSGPQQQPQPPAQLVGPAQSGLLQQQQQDFDPVQRYKMLIPQLKESLQTLMKVAAQNLIQNTNIDNGQKSSDGPIQRFDKCLEEFYALCDQLELCLRLAHECLSQSCDSAKHSPTLVPTATKPDAVQPDSLPYPQYLAVIKAQIACAKDIHTALLDCANKVTGKTPAPPTGPGGTL
What is the function of this protein?
Component of the mediator complex, a complex that can either repress or activate transcription.  Mediator complexes are essential for basal and regulated expression of nearly all RNA polymerase II-dependent genes.  They may act as a bridge, conveying regulatory information from enhancers and other control elements to the promoter (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 29, Intersex-like protein, Mediator complex subunit 29.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 29 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLMD_HAEI8
Sequence: MVLLYTPKQKTNNVQTITADILDLDYQGLGVAKINGKTWFIENALPHEKVECRILEDKRQYGHATAKKWRVKSSERLEPKCAHFMRCGGCQGQHIPIEMQRKAKQSALFKRLSKLQSEPISFQPMICGDAWAYRRRVRLSLWFNPNTKQIDMGFRQKNTNDLIPVQSCEVAEPAINYLLPKLTALLEKFSTPKQLGHIELVAADNGVAMLLRYTKNLAEIDRTLLLKFAEQEKLMLFLQSDKGIEQIYGDAPYYQFSDGIKLHFDIRDFIQVNSALNERMINTALDWLELSQQDCVLDLFCGMGNFTLPLAKRVKSAVGIEGVFEMVQKAAQNAARNQIKNIEFFQADLDQSFVEQPWANQSFNKILLDPPRSGAAFALNALCELKAEKILYVSCNPATLVRDAEILCDFGYKIEKSAVIDMFPHTGHLESITLFTTK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: RK22_AETCO
Sequence: MIKKKKKKSYTSVYALGQYISMSTHKARRVIDQIRGRSYEEALMILELMPYRGCYPIFKLVYSAAANASHNKGFKETNLVISKAEVNQGNTVKKLKPRARGRSYPIKRPTCHITIVLEDRSFDQQYDEYLMYLKNPGYRNAKINLPCYETYSSGGLWDKK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BRL2_ORYSJ
Sequence: MDILIPLLLSSIYVSSSAAAAETDAAALLRFKAFVHKDPRGVLSSWVDPGPCRWRGVTCNGDGRVTELDLAAGGLAGRAELAALSGLDTLCRLNLSGNGELHVDAGDLVKLPRALLQLDLSDGGLAGRLPDGFLACYPNLTDVSLARNNLTGELPGMLLASNIRSFDVSGNNMSGDISGVSLPATLAVLDLSGNRFTGAIPPSLSGCAGLTTLNLSYNGLAGAIPEGIGAIAGLEVLDVSWNHLTGAIPPGLGRNACASLRVLRVSSNNISGSIPESLSSCHALRLLDVANNNVSGGIPAAVLGNLTAVESLLLSNNFISGSLPDTIAHCKNLRVADLSSNKISGALPAELCSPGAALEELRLPDNLVAGTIPPGLSNCSRLRVIDFSINYLRGPIPPELGRLRALEKLVMWFNGLDGRIPADLGQCRNLRTLILNNNFIGGDIPVELFNCTGLEWVSLTSNQITGTIRPEFGRLSRLAVLQLANNSLAGEIPRELGNCSSLMWLDLNSNRLTGEIPRRLGRQLGSTPLSGILSGNTLAFVRNVGNSCKGVGGLLEFAGIRPERLLQVPTLKSCDFTRLYSGAAVSGWTRYQTLEYLDLSYNSLDGEIPEELGDMVVLQVLDLARNNLTGEIPASLGRLRNLGVFDVSRNRLQGGIPDSFSNLSFLVQIDISDNNLSGEIPQRGQLSTLPASQYAGNPGLCGMPLEPCGDRLPTATMSGLAAAASTDPPPRRAVATWANGVILAVLVSAGLACAAAIWAVAARARRREVRSAMMLSSLQDGTRTATTWKLGKAEKEALSINVATFQRQLRKLTFTQLIEATNGFSTASLIGSGGFGEVFKATLKDGSCVAIKKLIHLSYQGDREFMAEMETLGKIKHKNLVPLLGYCKIGEERLLVYEFMSHGSLEDTLHGDGGRSASPAMSWEQRKKVARGAARGLCFLHYNCIPHIIHRDMKSSNVLLDGDMEARVADFGMARLISALDTHLSVSTLAGTPGYVPPEYYQSFRCTVKGDVYSFGVVLLELLTGRRPTDKDDFGDTNLVGWVKMKVGDGAGKEVLDPELVVEGADADEMARFMDMALQCVDDFPSKRPNMLQVVAMLRELDAPPPATAI
What is the function of this protein?
May be involved in brassenosteroid (BR) perception.
What are the official names of this protein?
Brassinosteroid LRR receptor kinase BRL2, BRI1-like receptor kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: HSLO_SHESR
Sequence: MIQDILHRYLFDNADVRGELVQLQDSYQQVIGSHAYPPVLQILLGELLAATSLLTATLKFSGDISVQLQGNGPVSLAVINGSNQQQLRGIARWDGELADDASLADLFGQGYMVITLTPDEGERYQGVVALDKPTLAACVEDYFNQSEQLPTALWLFADGKQAAGMFLQVLPSQEDHNADFEHLCQLTATIKAEELFTLEAQEVLHRLYHQEDVRLFDPIEVCFKCTCSRERSAAAIKTIDQAEVEAILAEDGKVEMGCEYCNAKYVFDGIDIAAIYANGTASNTQQ
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALKMO_RAT
Sequence: MRNPGAQDNVSVSQGMRAMFYMMKPSETAFQTVEEVPDYVKKATPFFIFLILLELVVSWILKGKPSGRLDDILTSMSAGVVSRLPNLFFRSLEVTSYIYIWENYRVCELPWDSPWTWYLTFLGVDFGYYWFHRMAHEINIIWAAHQAHHSSEDYNLSTALRQSVLQQYSSWVFYCPLALFVPPSVFAVHIQFNLLYQFWIHTEVIRTLGPLELVLNTPSHHRVHHGRNRYCIDKNYAGTLIIWDRIFGTFEAENEQVIYGLTHPIGTFEPFKVQFHHLLYIWTTFWATPGFCHKFSVLFKGPGWGPGKPRLGLSEEIPEVTGQEVPFTSSASQFLKIYAVLQFAVMLVFYEETFANTAVLSQVTILLRICFIILTLTSIGFLLDQRPKAAIVETLRCLLFLTLYRFGHLKPLIESLSFAFEIFFSVCIAFWGVRSITHLASGSWKKP
What is the function of this protein?
Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids.  Ether lipids are essential components of brain membranes (By similarity).
What are the official names of this protein?
Alkylglycerol monooxygenase, Transmembrane protein 195.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family. TMEM195 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: AMPA_TOLAT
Sequence: MEFGVKSGSPEKQRSACIVVGVFEPRRLSAVAEQLDRVSDGYLSSLLRRGDLEGKTGQMLLLHQVPGVLSERVLLVGCGKERELDERQFKQIIQKTISTLNETGSMEAVCFLTELHVKGRDAYWKVRQAVETAQNSLYTFDQFKTNKAELRRPLRKLVFNVATRRELSIGEKAIAHGLAISNGMKICRDVANMPPNICTPAYLASQARRLADSCQYITTKVIGEQQMAELGMNAYLAVAKGSSNEAMMSVMEYKGHPDAKPIVLVGKGLTFDSGGISIKPAEGMDEMKYDMGGAASVLGTMTALAELKPPINVIGVLAGAENMPDGKAYRPGDILTSMSGQTIEVLNTDAEGRLVLCDVLTYVERFEPESVVDIATLTGACVIALGSHASGLMSNHNPLAHELLNASELSGDKAWRLPLWDEYQEQIESPFADMVNTGGRPAGAITAGAFLSRFTKKYNWAHLDIAGTAWKSGKEKGSTGRPVPLLTQFLLNRAGVEVED
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_STAAB
Sequence: MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQRAQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETLHNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLATYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVIQQLDVAKQLLSQ
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOA_RICBR
Sequence: MLQNSELLQEYLPIAIFFGIATLVSSLIMILPNLLATKKYNKDKLEPYECGFEPFDDARSKFDIRFYLVAILFIIFDLEITFLVPWAISLGTIGKIGFFSMMFFLFVLTIGFVYEWKKGALDWE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PNP_DESAH
Sequence: MEQVFKTELNGKEFSLRAGKIAKQASGSVIVQYGETIVLVTAVAAKEARDSVSFLPLTVEYQEKIYAAGRIPGNYFRREIGRPSEKETLTARLIDRPIRPLFEKGWASEIQVIATVISTDKENDPDVLALVGASAALQMSDIPFAGPIAGLRVGRIDGKFIANPTVQEMENSDIELVVAGSKTGVVMVEGGADVVSEADMLEAIFFGHQAMQPLIQLQEDLKKALGKEKRAYTPPLVDEELMAKVVELAQDKIHTAVQTQGKFERVKALDDVRTEVIETLGEAFADRINEIKSMFGDLVKKVSRKIVLTENQRIDGRAFDEVREITCEVGVLPRPHGSALFTRGETQVLGVLTLGSGPDEQRIETLNGNETRNFMLHYNFPPFSVGECRRAGGPSRRDVGHGNLAHRALARVLPDQADFEYTIRLVGEVMESNGSSSMGTVCAGTLALMDGGVPIAAPVSGIAMGLVSDADNTVVLTDILGDEDHFGDMDFKVAGTEQGITALQMDIKIRELPKAVLVKALDQARIGRLHILKRMLATLEIHRDKMSPYAPKIITVKINPDKIREIIGPGGKMIRSIQADTNTNIEVDDSGLIKIAAENQEDGEAAAKIVSDIGMDPEIGGIYEGEVVKTTDFGAFVRIKTGTDGLVHISELANHRVKKVTDVVKEGEVIRVKVLEITRDGKIRLSCKALEEEEK
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRI_ECOHS
Sequence: MTHDNKLQVEAIKRGTVIDHIPAQIGFKLLSLFKLTETDQRITIGLNLPSGEMGRKDLIKIENTFLSEDQVDQLALYAPQATVNRIDNYEVVGKSRPSLPERIDNVLVCPNSNCISHAEPVSSSFAVRKRANDIALKCKYCEKEFSHNVVLAN
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: RPOC_RICTY
Sequence: MSVVNFYGQLSNTQQFDQIRINIASPDQVRSWSFGEVTKPETINYRTFKPEKDGLFCARIFGPVKDYECLCGKYKRMKNRGITCEKCGVEVTVSRVRRERMGHIELAAPVAHIWFLKSLPSRISTLLDMTMRDVEKILYFENYVVVDPGLSILQKGELLTEEELQKAKDKYGEDAFTASIGAEVIQQMLKELDFSKLKQELYDELHITSSEVKKKKLVKRLKLVEDFLESENKPEWMIMDVLPVIPPEIRPLVMLDGGRFATSDLNELYRRVINRNNRLKKLIESKAPDIIVRNEKRMLQEAVDALFDNGRRGRAAKNANKRPFKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFIYSKLELYGIATTIKAAKRMVEAEKPEVWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPLLIEGKAIQLHPLVCAAFNADFDGDQMAVHIPLSIEAQLEARVFMMSTNNILSPANGRPIIVPDKDIVLGLYYLTIAFDNEVGEGMMFSDLAEMEHALYNKFITIHTKIKYRRDQLNAEGKMVPVIIDTTYGRLMVGELLPSNPNIEFKCINKQLTKKDISLVIDLVYRHCGQKATVIFADQLMKLGFKYACSSGISFGMDDMVVPESKSTHINETQLEIKEFEQQYSNGLITYGEKYNKVVDAWSRCTDRVANDMMKEIATPPINDYPNHQRINAIYMMAISGARGSFQQIKQLGGMRGLMTKSNGQIIQTPIISNFKEGLTEFECFNSANGMRKGQIDTALKTASSGYLTRKLVDVAQDCIITEKDCGTDKGIEVKSVIEGGEIIVPLAEKILGRTAAIDIFHPVTNDLILNKGELINESKLEQIESAGLDRIMIKSVLTCESSTGICSICYGRDLATGTLVSEGEAIGVIAAQSIGEPGTQLTMRTFHIGGAATKGAEVSSVEASYDAKVKIISRNVVINSEERKIVMSRNCELLLLDDNGNEKARHKIPYGARLLVDDGDIVIKTQKLAEWDPYTIPIITEKSGKVLFKDMVEGISIRDVTDEATGIPSKVIIESKQYSRGAELRPRIQLLDSKGEVITLSNGLEARYYLPVGAVLSVEDGIQISVGDIIARIPKESTTTKDITGGLPRVAELVEARRPKDHAVIAEVDGRVEFGKDYKSKRRIIIHPIDGTLSIEYMVPKGKHVVVNEGDFVKKGDLLIDGNPVLQDILKVMGVEVLANYIVKEVQAVYRLQGVKIDDKHIEVIIRQMLQKVEVTDSGGTTLLVGEKIDRHEFDEINEKAMKNGLKPAEAQLILQGITKASLQTRSFISAASFQETTRVLTEAAIAGKVDKLRGLKENVIVGRLVPAGTGYFMDKMRKAAVKLDEENV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: CXCR4_CANLF
Sequence: MEELHIYPSDNYTEEDLGSGDYDSMKEPCFREENAHFNRIFLPTVYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVLTLPFWAVEAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVREADDRYICDRFYPNDSWLVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGYQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFEKTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
What is the function of this protein?
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation.  Involved in the AKT signaling cascade (By similarity).  Plays a role in regulation of cell migration, e. g.  during wound healing.  Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels.  Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity).  Involved in hematopoiesis and in cardiac ventricular septum formation.  Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells.  Involved in cerebellar development.  In the CNS, could mediate hippocampal-neuron survival (By similarity).
What are the official names of this protein?
C-X-C chemokine receptor type 4, CXC-R4, CXCR-4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) (By similarity).