PharMolix/UniProtQA huggingface dataset:
Protein: LIPA_NEOSM
Sequence: MERTIEKPRIRVSADNRAFLETSRLVSACGLNTVCQEAACPNISECWSSKHVTVMILGSVCTRACRFCNVTTGKPELLDPHEPEKLASAVGKLGLRHVVITSVDRDDLDDGGAEHFASCVRRIRETSPGTSIEVLTPDFLGKVGARDIIIAAAPDVFNHNVETVPRLHPKIRIKARYFNSLSLLEEVKRKDPRIFTKSGLMLGLGEERSEVLQVMDDMRVAGIDFLTIGQYLRPSKKHMEVQRYATDEEFQYYKEAAYARGFLMVASSALTRSSYHADEDFLHLKNARAGALAKLV
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_KORVE
Sequence: MNLSNLRAPRKANEKKKRVGRGMGSGMGKTSARGHKGQRSRSGSRMMRGFEGGQMPLHRRLPKRGFTNIFRVEYAVVNLDRLAELGLTEITPEVLIKHKLAGKNDKIKVLGNGEIKGAVTVRAHKFSKTAEEKIAKAGGKAEVL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: GSPD_VIBCH
Sequence: MKYWLKKSSWLLAGSLLSTPLAMANEFSASFKGTDIQEFINIVGRNLEKTIIVDPSVRGKVDVRSFDTLNEEQYYSFFLSVLEVYGFAVVEMDNGVLKVIKSKDAKTSAIPVLSGEERANGDEVITQVVAVKNVSVRELSPLLRQLIDNAGAGNVVHYDPANIILITGRAAVVNRLAEIIRRVDQAGDKEIEVVELNNASAAEMVRIVEALNKTTDAQNTPEFLKPKFVADERTNSILISGDPKVRERLKRLIKQLDVEMAAKGNNRVVYLKYAKAEDLVEVLKGVSENLQAEKGTGQPTTSKRNEVMIAAHADTNSLVLTAPQDIMNAMLEVIGQLDIRRAQVLIEALIVEMAEGDGINLGVQWGSLESGSVIQYGNTGASIGNVMIGLEEAKDTTQTKAVYDTNNNFLRNETTTTKGDYTKLASALSSIQGAAVSIAMGDWTALINAVSNDSSSNILSSPSITVMDNGEASFIVGEEVPVITGSTAGSNNDNPFQTVDRKEVGIKLKVVPQINEGNSVQLNIEQEVSNVLGANGAVDVRFAKRQLNTSVMVQDGQMLVLGGLIDERALESESKVPLLGDIPLLGQLFRSTSSQVEKKNLMVFIKPTIIRDGVTADGITQRKYNYIRAEQLFRAEKGLRLLDDASVPVLPKFGDDRRHSPEIQAFIEQMEAKQ
What is the function of this protein?
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.  Required for secretion of cholera toxin through the outer membrane.  This subunit forms the outer membrane channel.
What are the official names of this protein?
Secretin GspD, Cholera toxin secretion protein EpsD, General secretion pathway protein D, GspD, Type II secretion system protein D, T2SS protein D.
What is the protein family that this protein belongs to?
Belongs to the bacterial secretin family. GSP D subfamily.
What are the subcellular locations of this protein?
Cell outer membrane. Note=Most of the protein is in the periplasm which it traverses to contact proteins of the cell inner membrane.
Protein: NUON_SALAI
Sequence: MSELKLPSIDYVALAPTLILLGAALVGVLVEAFVPRRLRHMVQLTVAMLAVLSALTMVVVNANDRLITIGGAIAVDGPALFLQGAILVLAAMALLLIGERSVERGGAFVAQAAVTAESADDRRQAEGRPGATEVYPLTSFAVGGMLIFVAANDLLTMFIALEVLSLPLYLLCALARRRRLLSQEAAMKYFLLGAYASAFFLFGVALVYGYTAGVPDRAAGVDFATIDAAVSESQSSSVLLFGGMALIAIGLLFKAAAAPFHVWTPDVYQGAPTPITGFMAACTKVAAFGALLRVFHVAFEGARWDFTPILGVVAVLTMLVGAVLAVTQTDIKRLLAYSSIANAGYLLVGVLAPSSEGVSGTMFYLVAYGFSVLAAFAVVTLVRDGDGEATHLSRWAGLGQRSPFYAGLFTFILLAFAGIPLTSGFTSKFAVFSAAFDGGQGWLVVAGVLTSMVLAFPYLRVVVLMWLSEPGESTPAVVMPGWLTSAALTIGVVATLVLGVVPQPLLDLAAGAAEFVR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BDNF_RAMSP
Sequence: SCMKAAPMKEVSLRGQGNLAYPGLRTQANLENLGGPNDATRGLTSLADTFEQVIEELLDEQQAIQPSKENKDADLYSSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCESTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCSSKGYTKEGCRGIDKRYWNSQCRTTQSYVRALTMDNKKRVGWRFIRIDTSC
What is the function of this protein?
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: S39A2_HUMAN
Sequence: MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFMVQNRSASERNSSGDADSAHMEYPYGELIISLGFFFVFFLESLALQCCPGAAGGSTVQDEEWGGAHIFELHSHGHLPSPSKGPLRALVLLLSLSFHSVFEGLAVGLQPTVAATVQLCLAVLAHKGLVVFGVGMRLVHLGTSSRWAVFSILLLALMSPLGLAVGLAVTGGDSEGGRGLAQAVLEGVAAGTFLYVTFLEILPRELASPEAPLAKWSCVAAGFAFMAFIALWA
What is the function of this protein?
Mediates zinc uptake.  Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin.  May also transport other divalent cations.  May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.
What are the official names of this protein?
Zinc transporter ZIP2, 6A1, Eti-1, Solute carrier family 39 member 2, Zrt- and Irt-like protein 2, ZIP-2, hZIP2.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FBPAP_THEON
Sequence: MAIGEKITISVIKADIGGWPGHSRVHPQLIEAAEEVLAKAKEEGTIIDFYVAYAGDDLQLIMTHKKGVDSPDIHGLAWKAFEEATEIAKEFGLYGAGQDLLKDAFSGNIRGMGPGIAEMEITLRKSEPIVTFHMDKTEPGAFNLPIFRMFADPFNTAGLVIDPNMHMGFRFEVWDIKEHKRVILNTPEEIYDLLALIGAKSRYVIKRVYPKEGHKISKDEPVAVISTEKLYEIAGEYVGKDDPVAIVRAQSGLPALGEVLEPFAFPHLVSGWMRGSHNGPIMPVPMHQANPTRFDGPPRVVALGWQISPEGKLVGPVDLFDDPAFDYARQKALEITEYIRRHGPFEPHRLPLEDMEYTTLPGVLKKLEERFEDIE
What is the function of this protein?
Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) (By similarity).  Can also dephosphorylate, with lower activity, other related substrates including fructose-1-phosphate, fructose-6-phosphate, glucose-1-phosphate, glucose-6-phosphate, glycerol-2-phosphate, phosphoenolpyruvate, 5'-AMP, 6'-ADP and 7'-ATP (PubMed:21221938).
What are the official names of this protein?
Fructose-1,6-bisphosphate aldolase/phosphatase, FBP A/P, FBP aldolase/phosphatase.
What is the protein family that this protein belongs to?
Belongs to the FBP aldolase/phosphatase family.
Protein: ACPS_SHEPA
Sequence: MIVGLGTDIVEIARIESRIPAAGDEALLTCRLAKRVLTETEFALFVGSTQPARYLAKRFAAKEAAAKALGTGIGRGVSFQHIEISNNDNGAPQVVFTDGASERLSQLGGVKAHLSIADEQHYATATVILES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAAB_METBU
Sequence: MVKVEKFIPNAIDRIKEQAKGKTIIALSGGVDSSVCAVLAYQAIKDDLIPIYIDTGLMRKGETERIKEIFADMNLQTIDAKDRFLDALVGIKDPEEKRKVVGETFIRVFEEEAREINAQYLIQGTIYPDRIESDGGIKSHHNVGGLPEHIDFKGIIEPIDDLYKDEVREVAWALDLPEEICERMPFPGPGLSVRIIGEVTEEKVDVVREANAIVEEELLEQFKPWQTFAAVIGKGTGVKGDVRVHGWIIAVRAVGSRDGMTAEALELPWETLMKIESRISGEIASVARVLYDLSPKPPATIEFE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase.
Protein: RS14_ERWT9
Sequence: MAKQSMKAREVVRVKLADKYRAKREELKAIISSVNSSDEDRWNAVLKLQSLPRDSSPSRQRKRCRQTGRPHGYVGKFGLSRIKLREAAMRGEVPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RSMG_RICRS
Sequence: MEVPREIIEKLEIFQKLVKKWNKSINLVSDNTIHNFWQRHILDSLQLIQYIDNKEIHLVDIGSGAGLPGIVLSIAGVAQVSLIEADLRKCIFLEKASKISNNNVQIINQRIEKVEIDCSILTCRAFSNLNTIFNCIKNISVREKFLLLKGKNYLTEIVEAKERWLFGYLIHQSITCEEGKILEVSNLTKMI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURT_FLAPJ
Sequence: MKILLLGSGELGKEFAIAAQRIGQTIIAVDNYPNAPAMQVAHQFEVINMLDGSELDRIVAKHQPDFIVPEIEAIRTERFYEYEKQGITVVPSAKAANFTMNRKAIRDLAAKELGLKTANYRYATSAEELQKGVQAVGMPCVVKPLMSSSGKGQSTIKTVEDIEKAWNYAVEGSRGDVVEVIVEAFVKFNSEITLLTVAQNNNPTLFCAPIGHRQERGDYQESWQPARISDKDLHEAQDMARKVTEALGGAGLFGVEFFLTNDGVYFSELSPRPHDTGMVTLAGTQNFNEFELHLRAILSLPIFDITLEKAGARAVILASENSNNPTYSGIENIACLPKSDFRIFGKPTSRPYRRMGVVLTNDTLETPIEEIVTRAKKMATLVKVNL
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: APT_BDEBA
Sequence: MDLKSLIRDVPDFPKPGIIFRDMSPLLQNAEALSFVSHNLLKHVDLTHVDYFAGIESRGFILAAHMAATHKKGFLPIRKAGKLPPPTRKVSYALEYGTAEIELPPGRGNVVIVDDVLATGGTLQAAIDLCLLAGYSVESVAVLVNLTFLNKMTYNDQKVASLVQY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSW_MARN8
Sequence: MQAGVSVPHYQGMAGELQPLPVLIITSVALLVTGVVMISSASMDMAAATLGNSYHYVIRQILFAGLGCATALVAVNVPVSWWERSGWLLLGIGLLVLVLVLTPLGRTVNGSTRWIPMGLFNVQVSEVAKLCLIAYLAGYVVRRREELLHTWPGFLKPLGVLGVASVLLVIQPDFGATVVLVTAAAGMIFLSGVRLSRFMPLIGVLAALGTILVVTQPYRLKRVISYLDPWKDQFDSGYQLTQSLIAFGRGEWVGVGLGNSVQKLFFLPEAHTDFIYAIIAEEFGLLGALVVLGLFAALVVSGLVIARRAEKAGMAFGACFSYGITLLIGLQAGINMAVSTGLLPTKGLTLPLVSYGGSSLMVTCIGIAVIARVELERQDRARVASETKGNRTKGGAVYD
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell division.
What are the official names of this protein?
Probable peptidoglycan glycosyltransferase FtsW, PGT, Cell division protein FtsW, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. FtsW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Protein: ASSY_LACE2
Sequence: MKEKVILAYSGGLDTTAIIPWLKETYNYDVVCVCADCGQEEELDGLEQRALSCGAAKLYIEDITDEFCDNYIVPCVQAHAVYENKYLLGTSMARPLIAKRLVEIARKEGAVAICHGATGKGNDQIRFELTIKALAPDIKIIAPWRDSNWKLQSREDEIEYCRQHGIHLPFSTDCSYSRDRNIWHISHEGLELEDPANEPNYKHLLVLGCTPEEAPDEPEYVTMTFEKGVPKSVNGKAMKVSDIIRELNRLGAKHGIGIIDIVENRVVGMKSRGVYETPGGTILYEAHQQLEELVLDRDTTTFKMDVGNKFAQVVYEGKWETPLREALQAFVEKTQEYVTGEVKFRLYKGNIIKAGTTSPYSLYNESIASFKTGDMYDHHDADGFINLFGLSLKVRAMKKLENEKKNNK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECQ1_PONAB
Sequence: MASVSALTEELDSITSELHAVEIQIQELTERQEELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWNKEDFPWSGKVKDVLQNVFKLQKFRPLQLETINVTMAGKEVFLVMPTGGGKGLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNTEDFIEDIVKLINGRYKGQSGIIYCFSQKDSEQVTVSLRNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNISKCRRLLMAQHFDEVWNSEACNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTLPREDLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNSFRVESSQTCHSEQGDKKMEEKNSGNFQKKAANMLQQSGSKNTGAKKRKIDDA
What is the function of this protein?
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens.  Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
What are the official names of this protein?
ATP-dependent DNA helicase Q1, DNA-dependent ATPase Q1, RecQ protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRR14_BOVIN
Sequence: MDLPGDSSTPGRQRLCRQPHAGALWGAKSPKRPKLQPLGAPSPLEKASRRVLAVVLEDVMAARMVPLEPQEESSTPRHHSNHRDSVRSQPPASPPRQAMWSPQARPPDPLHLCREPLSRIRRPPSTPRRQSRTTPGPDEGPSQKVDQVHQPTLVVMLQDIASSRPRAEGFADEAPNFIIPARRAEPKVMVHQPKPPSRDLPAPSRPSALSANPLASPPPAPDPVLEPPSTPPPSSLLRPRLSPWGLAPLFHSVRSKLESFADIFLTPNKAPRPPPPSPPMKLELKIAISEAGQPGASEGTVTVSPRPPIRQWRAQDQNPSATLTKPSLGRSHSCPDLGPPGPDPCSWPPVPAPSSRPRPRRHTVGGGEMAKAPPPPRPCLRKEVFPLGGVGASPPLVTSCSSTASTSSFSEPAEPRLSSTKRKEPRAPEDQVLPDSETKTIGKVSRFRIRRTPARSQINLTPMGLPRPVRLNKKEFSLEEIYTNKNYQSPTTRRTFETIFEEPRERNGTLIFTSSRKLRRTVEFRDSSLPRSRRPSRGARATAGRTLPPSLAPSPDVEPLLQQRLQELDASLLEEEEEGDQDQPHRT
What is the function of this protein?
Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha.  Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit.  Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha.  Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (By similarity).
What are the official names of this protein?
Proline-rich protein 14.
What are the subcellular locations of this protein?
Chromosome. Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Note=During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase.
Protein: SYGB_PSEU2
Sequence: MSAQDFLVELGTEELPPKTLVSLADAFLAGIEKGLAGAGLTYSAKQVYAAPRRLAVLITALATQQPDRSVNLDGPPRQAAFDADGNPTQAALGFAKKCGVDLSEIDQSGPKLRYSQTILGKPTTSLLPTIVEDSLNDLPIAKRMRWGARKEEFVRPTQWLVMLFGDQVVDCTILAQSAGRHSRGHRFHHPQDVRISSPAGYLSDLRAAHVLADFNERRQIISKRVDELATQQEGTAIVPPSLLDEVAGLVEWPVPLVCSFEERFLEVPQEALITTMQDNQKYFCLLDVDGKLLPRFITVANIESKDPAQIIAGNEKVVRPRLTDAEFFFKQDKKQKLETFNDRLKNVVFQAQLGSVFDKAERVSKLAAYIAPRIGGDAQRAARAGLLSKCDLSSEMVGEFPEMQGIAGYYYAKADGEPEDVALALNEQYMPRGAGAELPTTLTGAAVAIADKLDTLVGIFGIGMLPTGSKDPYALRRAALGILRILIEKKLDLNLVETVKFAVAQFGAKIKPAGLAEQVLDFIFDRLRARYEDEGVDVAVYLSVRALQPASALDFDQRVQAVQAFRKLPQAAALAAVNKRVSNLLSKAEGSIAQTVEPKYFDNANEFSLYSAIQQADHAIQPMAAERQYSESLARLAMLREPVDAFFEAVMVNAEDANVRANRYALLSRLRGLFLGVADISLLG
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB6A_RAT
Sequence: MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVNEGGCSC
What is the function of this protein?
Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).  Has a low GTPase activity.  Involved in COPI-independent retrograde transport from the Golgi to the ER.  Recruits VPS13B isoform 2 to the Golgi membrane.  Plays a role in neuron projection development.
What are the official names of this protein?
Ras-related protein Rab-6A, Rab-6.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Note=BICD2 facilitates its targeting to Golgi apparatus membrane.
Protein: MFRN_CAEBR
Sequence: MGGGGEDEYESLPTHSIPVHLAAGALAGAVEHCVMFPFDSVKTRMQSLCPCETKCPTPVHSLMSIVKREGWLRPLRGVNAVAAGSMPAHALYFTVYEKMKSFLTGNTAGHEHTLAYGASGVVATLIHDAVMNPAEVVKQRMQMAYSPYGSSLECARCVYNREGFAAFYRSYTTQLAMNVPFQAIHFMGYEFWQQVLNPEHKYDPKSHLIAGGLAGGLAAAVTTPMDCVKTVLNTQQAAEADPSNRRIFLKARYRYRGISDAVRTIYSQRGMAGFSCGLQARVIFQVPATALSWSVYELFKFMLSFEGGHSS
What is the function of this protein?
Mitochondrial iron transporter that mediates iron uptake.  Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly.
What are the official names of this protein?
Mitoferrin.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: XYL1_HYPJE
Sequence: MASPTLKLNSGYDMPQVGFGLWKVDNAVCADTVYNAIKAGYRLFDGACDYGNEKECGEGVARAIKDGLVKREDLFIVSKLWQTFHDEDKVEPITRRQLADWQIDYFDLFLVHFPAALEYVDPSVRYPPGWFYDGKSEVRWSKTTTLQQTWGAMERLVDKGLARSIGVSNYQAQSVYDALIYARIKPATLQIEHHPYLQQPDLVSLAQTEGIVVTAYSSFGPTGFMELDMPRAKSVAPLMDSPVIKALADKHRRTPAQVLLRWATQRGIAVIPKTSRPEVMAQNLDNTSFDLDSEDLAKIADMDLNIRFNKPTNYFSANKLYLFG
What is the function of this protein?
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol.  Xylose is a major component of hemicelluloses such as xylan.  Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.  Also major aldose reductase in pentose and D-galactose catabolism.  Reduces the pentose L-arabinose and the hexose D-galactose to their respective polyols.  Responsible for extracellular beta-galactosidase formation and cellulase induction during growth on lactose.
What are the official names of this protein?
NAD(P)H-dependent D-xylose reductase xyl1, XR.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: MMDA_PROMO
Sequence: MSVAAKKIQDLQKKKEKIALGGGIKRIEKQHASGKMTARERLAYLFDEGTFVEMDAFVQHRCTNFGMDKQDLPSESVVTGYGMVDGRVVYAFSQDFTVTGGALGEMHAKKICKAMDMAGKVGAPVVGLNDSGGARIQEAVDALSGYGDIFYRNSIYSGVVPQISAILGPCAGGAVYSPALTDFIFMVDQTSQMFITGPQVIKTVTGEEVTAEQLGGAMTHNSTSGCAQFISQDDKACIDDIRRLISFLPSNNMEKAPEFGCEDDLNIQFPELDALMPDNPNKAYNMFDVITKIVDNGDYMEYQPHYSKNIITCFARVNGKSVGIIANQPQVMAGCLDIDSGDKCAKFIRTCDAFNIPLLTIVDVPGFLPGVTQEYGGIIRHGAKILYAYSEATVPKVTLITRKAYGGAYVAMCSKSLGADVVLAWPTAEIAVMGPAGAVNIIFRKDIKDAKDPAATTKQKLDEYTTEFANPYQAARRGLVDDVIEPKTSRQRIVDAFNMLEGKREKLPAKKHGNIPL
What is the function of this protein?
Carboxyltransferase subunit of the sodium ion pump methylmalonyl-CoA decarboxylase, which converts the chemical energy of a decarboxylation reaction into an electrochemical gradient of Na(+) ions across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis (PubMed:9428714).  The alpha subunit catalyzes the Na(+)-independent carboxyltransfer from methylmalonyl-CoA to the prosthetic biotin group located on the gamma subunit (By similarity).
What are the official names of this protein?
Methylmalonyl-CoA decarboxylase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: CYSK_STAEQ
Sequence: MAQKPVDYVTQIIGNTPVVKLRNVVDDDAADIYVKLEYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIGLAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEIHELTTGPELVEQFEGRQIDAFLAGVGTGGTLSGVGKVLKKEYPNVEIVAIEPEASPVLSGGEPGPHKLQGLGAGFVPDTLNTEVYDSIIKVGNDTAMDMARRVAREEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERYLSTPLYSFDN
What are the official names of this protein?
Cysteine synthase, CSase, O-acetylserine (thiol)-lyase, OAS-TL, O-acetylserine sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Protein: YBAT_ECOLI
Sequence: MMNTEGNNGNKPLGLWNVVSIGIGAMVGAGIFALLGQAALLMEASTWVAFAFGGIVAMFSGYAYARLGASYPSNGGIIDFFRRGLGNGVFSLALSLLYLLTLAVSIAMVARAFGAYAVQFLHEGSQEEHLILLYALGIIAVMTLFNSLSNHAVGRLEVILVGIKMMILLLLIIAGVWSLQPAHISVSAPPSSGAFFSCIGITFLAYAGFGMMANAADKVKDPQVIMPRAFLVAIGVTTLLYISLALVLLSDVSALELEKYADTAVAQAASPLLGHVGYVIVVIGALLATASAINANLFAVFNIMDNMGSERELPKLMNKSLWRQSTWGNIIVVVLIMLMTAALNLGSLASVASATFLICYLAVFVVAIRLRHDIHASLPILIVGTLVMLLVIVGFIYSLWSQGSRALIWIIGSLLLSLIVAMVMKRNKTV
What is the function of this protein?
Probable amino-acid or metabolite transport protein.
What are the official names of this protein?
Inner membrane transport protein YbaT.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYB_DACDA
Sequence: MTNMRKSHPLIKIINHSFIDLPAPSNISAWWNFGSLLGVCLALQIITGLFLAMHYTADTTTAFSSVTHICRDVNYGWLIRYAHANGASMFFIFLYFHIGRGIYYGSYTFMETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGPTLVEWIWGGFSVDKATLTRFFAFHFILPFIITAMVMIHLLFLHETGSNXPSGLNSDXDKIPFHPYYTIKDILGILFMALALLMLTLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAVLRSIPNKLGGVLALALSILILMLFPSLHLSKQRSMSFRPLSQCLLWILVANLIILTWIGGQPVEPPFITIGQLASISYFCIILILMPTMSLMENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.