PharMolix/UniProtQA huggingface dataset:
Protein: UL141_HCMVM
Sequence: MCRRESLRTLPWLFWVLLSCPRLLEYSSSSFPFATADIAEKMWAENYETTSPAPVLVAEGEQVTIPCTVMTHSWPMVSIRARFCRSHDGSDELILDAVKGHRLMNGLQYRLPYATWNFSQLHLGQIFSLTFNVSTDTAGMYECVLRNYSHGLIMQRFVILTQLETLSRPDEPCCTPALGRYSLGDQIWSPTPWRLRNHDCGMYRGFQRNYFYIGRADAEDCWKPACPDEEPDRCWTVIQRYRLPGDCYRSQPHPPKFLPVTPAPPADIDTGMSPWATRGIAAFLGFWSIFTVCFLCYLCYLQCCGRWCPTPGRGRRGGEGYRRLPTYDSYPGVKKMKR
What is the function of this protein?
Evasion of NK cell killing.  Blocks surface expression of PVR which is a ligand for NK cell-activating receptors.  Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface.  Targets also the natural killer cell activating ligand NECTIN2 for proteasome-mediated degradation.  Additionally promotes intracellular retention of TNFRSF10A/TRAIL-R1 and TNFRSF10B/TRAIL-R2 and thus down-regulates their cell surface expression.
What are the official names of this protein?
Protein UL141.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: Y215_GEOUR
Sequence: MRIVYFDCFAGIAGDMTVAALIELGVPIDYLREELAKLPLPLSAYSISVEQVQRKGIAATRFHVRAEEHQPHRHYTDIAAMIEQSTLSDRVKEMAQRVFFRLAEAEARVHGVEIGHVHFHEVGGVDSIVDIVGAAICLDYLGIGELHVSPLPLGSGFVETAHGRLPVPAPATAELLRGIPVHGDVGPGERVTPTGAAIVAALADSFGRAPAMRVVAVGCGAGSKDFDDMPNVVRLVMGEKTAILLKDEIYVIETHIDDMNPEILGFLMERLLACGALDVAFSPLQMKKNRPGSKLTILSSFDKLDELARLVLTESTAIGVRYYPVARMILSRAMEERDTSLGRVKVKVVSDEAQLLRIVPEFEECRRLAREKGLPLMEVYRIIERETAGQ
What are the official names of this protein?
Putative nickel insertion protein.
What is the protein family that this protein belongs to?
Belongs to the LarC family.
Protein: SYC_SYNP6
Sequence: MTLSLYNTLTRQKQRFEPLQAGSVSLYCCGVTVYDYCHLGHARSYIVWDTLRRYLLWLGYRVRYVQNFTDIDDKILRRSRQEGTTMQAIADRYTQAYFEDMARLNILEADDYPRATHTLDGIQRLIAELEDKGFAYAADGDVYFSVRRFQDYGKLSGRKLEDLKAGASGRVESAEESLKHDPFDFALWKAAKPEEPAWDSPWGPGRPGWHIECSAMVRDRLGDSIDIHVGGADLVFPHHENEIAQSEAVTGHPLARYWLHNGMVNVGGEKMSKSLGNFTTIRQLLDEGGISPMVLRLFVLQANYRKPIDFTDEALQACQNGWETLQEGLHFGEHWGDRLGWTESVTVDPDLSDRFRMAMDDDLNTPAALAVLFELAKELRRQQNLLIHEGHLDGDAQQLHQHWVTLVQLAGVLGLEAEPELAETNELDEAAIEDWIAKRHAARQAKDFAEADRIRHYLADLGITLIDQAGGITRWSRT
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLST_MYCBP
Sequence: MNSEHPMTDRVVYRSLMADNLRWDALQLRDGDIIISAPSKSGLTWTQRLVSLLVFDGPDLPGPLSTVSPWLDQTIRPIEEVVATLDAQQHRRFIKTHTPLDGLVLDDRVSYICVGRDPRDAAVSMLYQSANMNEDRMRILHEAVVPFHERIAPPPFAELGHARSPTEEFRDWMEGPNQPPPGIGFTHLKGIGTLANILHQLGTVWVRRHLPNVALFHYADYQADLAGELLRLARVLGIAATRDRARDLAQYATLDAMRSRASEIAPNTTDGIWHSDERFFRRGGSGDWQQFFTEAEHLRYYHRINQLAPPDLLAWAHEGRRGYDPAN
What is the function of this protein?
Involved in the synthesis of cell wall sulfolipids.
What are the official names of this protein?
Glycolipid sulfotransferase BCG_1434.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
Protein: PSTB_STAHJ
Sequence: MANTNVKEKELAKHTDQSQESISTVVSSNEVKHNKESDSNKKVVYSTQNLDLWYGDTHALQNINLDILENNVTAIIGPSGCGKSTYIKTLNRMVELVPSVKTAGKILYRDQNIFDENYSKEKLRTNVGMVFQQPNPFPKSIYDNITYGPKTHGIKDKKLLDEIVEKSLRGAAIWDELKDRLHTNAYGLSGGQQQRVCIARCLAIEPDVILMDEPTSALDPISTLRVEELVQELKENYSIIMVTHNMQQAARVSDKTAFFLNGYVNEYDDTDKIFSNPSDKQTEDYISGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: IE1_NPVAC
Sequence: MTQINFNASYTSASTPSRASFDNSYSEFCDKQPNDYLSYYNHPTPDGADTVISDSETAAASNFLASVNSLTDNDLVECLLKTTDNLEEAVSSAYYSESLEQPVVEQPSPSSAYHAESFEHSAGVNQPSATGTKRKLDEYLDNSQGVVGQFNKIKLRPKYKKSTIQSCATLEQTINHNTNICTVASTQEITHYFTNDFAPYLMRFDDNDYNSNRFSDHMSETGYYMFVVKKSEVKPFEIIFAKYVSNVVYEYTNNYYMVDNRVFVVTFDKIRFMISYNLVKETGIEIPHSQDVCNDETAAQNCKKCHFVDVHHTFKAALTSYFNLDMYYAQTTFVTLLQSLGERKCGFLLSKLYEMYQDKNLFTLPIMLSRKESNEIETASNNFFVSPYVSQILKYSESVQFPDNPPNKYVVDNLNLIVNKKSTLTYKYSSVANLLFNNYKYHDNIASNNNAENLKKVKKEDGSMHIVEQYLTQNVDNVKGHNFIVLSFKNEERLTIAKKNKEFYWISGEIKDVDVSQVIQKYNRFKHHMFVIGKVNRRESTTLHNNLLKLLALILQGLVPLSDAITFAEQKLNCKYKKFEFN
What is the function of this protein?
Regulatory transcriptional protein, which trans-activates gene expression from early baculovirus promoters.  Can also trans-activate its own promoter, suggesting an autoregulation during infection of host cells.  Promotes also viral DNA genome replication via the N-terminal region.
What are the official names of this protein?
Trans-activating transcriptional regulatory protein, Immediate early protein 1, IE-1.
What is the protein family that this protein belongs to?
Belongs to the nucleopolyhedrovirus IE-1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: IMDH1_BOVIN
Sequence: MADYLISGGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFTADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKIRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRNELVVAPAGVTLKEANEILQRSKKGKLPIVNDRDELVAIIARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.  Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism.  It may also have a role in the development of malignancy and the growth progression of some tumors.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase 1, IMP dehydrogenase 1, IMPD 1, IMPDH 1.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SCX17_CENTE
Sequence: MNSLLMITACLVLIGTVWAKKDGYLVDKTGCKKTCYKLGENDFCNRECKWKHIGGSYGYCYGFGCYCEGMSDSTPTWPLPNKRCGKK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity).  Is possibly lethal to mice, freshwater shrimp and crickets (PubMed:27130039).
What are the official names of this protein?
Beta-toxin Ct17.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SRPB_YEAST
Sequence: MLSNTLIIACLLVIGTTIALIAVQKASSKTGIKQKSYQPSIIIAGPQNSGKTSLLTLLTTDSVRPTVVSQEPLSAADYDGSGVTLVDFPGHVKLRYKLSDYLKTRAKFVKGLIFMVDSTVDPKKLTTTAEFLVDILSITESSCENGIDILIACNKSELFTARPPSKIKDALESEIQKVIERRKKSLNEVERKINEEDYAENTLDVLQSTDGFKFANLEASVVAFEGSINKRKISQWREWIDEKL
What is the function of this protein?
Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity).  Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).  May mediate the membrane association of SR (By similarity).
What are the official names of this protein?
Signal recognition particle receptor subunit beta, SR-beta.
What is the protein family that this protein belongs to?
Belongs to the SRP receptor beta subunit family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: LDF1B_XENLA
Sequence: MASAEKLYREKMQELQKQLNKFMQTINNHSKVDAFLNSPFGQYLDEHPFVTLSLLVFVSLSVVPAGLFLTLVAGTAIAVCLAVLIIEGIVISVSGIALLCILCGLAVMSLGVAAILCVSYVAGSSVFNYMHAYRVAVGTRERSGPISLNHKMTMAEKSLSSS
What is the function of this protein?
Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis.
What are the official names of this protein?
Lipid droplet assembly factor 1-B, Promethin-B, Transmembrane protein 159-B.
What is the protein family that this protein belongs to?
Belongs to the LDAF1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet.
Protein: Y370_RICPR
Sequence: MILNMTINYIKKDRYKVLNLVLITISIIALSTAYIAEYIFHYTPCPLCVYERFPYLMLIKISLTALIIRQLNKYTLILILITILSSCILSTYHSFVERGIVQPSAICSSMIRIPQGLSIQHIKQMFYSQPITSCTKPAIKILGISMTEYNLLLNICLLIFLGLILFYPKSNK
What are the official names of this protein?
Uncharacterized protein RP370.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSD_HELPY
Sequence: MVALSNALSRVFGSLAGYKFPSFIQKGINALYVKIFKIDLSEFEPLENYRSLNALFTRSLKKERPFDKSPNICIAPCDALITECAFLDNDSALQIKGMPYKAHELVGEINPLSPSFFYANFYLSPKDYHHYHAPCDLEILEARYFAGKLLPVNKPSLHKNNNLFVGNERVTLVAKDIQGNRLYFVAVGALNVGKMRFNFDKNIQTNAKARFTQTYSYNPPIKVKKGDNLGNFEMGSTIVLFIQNTAFKDLKEKNVKFGESIGEFHAN
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TGT_CLOP1
Sequence: MTKKRYTLLKKDGKARRGEFVTPHGTIQTPVFMNVGTLAAIKGAVSSMDLKEIGCQVELSNTYHLHLRPGDKIVKQMGGLHNFMNWDRPILTDSGGFQVFSLAGMRKIKEEGVYFNSHIDGRKIFMGPEESMQIQSNLGSTIAMAFDECIPNPSTREYVEKSVARTTRWLERCKKEMDRLNSLDDTVNKEQMLFGINQGGVYEDIRIEHAKTIREMDLDGYAIGGLAVGETHEEMYRVIDAVVPHLPEDKPIYLMGVGLPSNILEAVERGVDFFDCVLPARNGRHGHVFTKEGKINLMNAKFELDARPIDEGCQCPACKNYTRAYIRHLFKAKEMLAMRLCVLHNLYFYNKLMEDIRDAIDGGYFAEFKAKKLEEWNGRA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: UREE_PSEA8
Sequence: MLVIHQRLPARSPRWDEELHLTYEARSKSRLRCFAASGEEVGLFLERGQPPLADGDCLEARDGRLVRVVARSERLLHVTCASPLELTRAAYHLGNRHVALQVGDGWLRLLDDYVLKAMLEQLGATVEAIEAPFQPEHGAYGGGHHHSHHGEAEFNYAPRLHQFGVRR
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRP_KLEAE
Sequence: MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR
What is the function of this protein?
A global transcription regulator.  Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription.  Induces a severe bend in DNA.  Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.  Plays a major role in carbon catabolite repression (CCR) (By similarity).
What are the official names of this protein?
cAMP-activated global transcriptional regulator CRP, Catabolite activator protein, CAP, Catabolite gene activator, cAMP receptor protein, CRP, cAMP regulatory protein.
Protein: GALT1_STRR6
Sequence: MKTIIDNFVDRVIEYGMYNEIDKIYVKNRVLALIGEEGTDRISDENDLKQIKDYLVEIALKNGKIKDLIEEKECLGAELMNFIVPLPSRLNDIFWSSYDISPQEAVEEFYKLSKDSDYIKTSAIAKNIEFRASTKYGELEITINLSKPEKDPKTIAAEKLVKATNYPKCLLCMENEGYQGRINYPARSNHRIIRLKLGDEVWGFQYSPYLYFNEHAIFLNSQHVPMAITSKTFEQLLEIVDILPGYFAGSNSDLPISGGSILSHNHYQGGKHIFPMEKAKFESEFRFKDFEDVNAGIVKWPMSVIRLQSENKNRLLDLATKILNKWREYSDLEVDIIAMTEDVPHHTVTPIARKVDGRYELDIVLRDNHTTEQYPDGVFHPHQDVQHIKKENIGLIEVMGLAILPPRLKPELEEVGKYLLGEDNAIADYHLEWADQLKEKYPRINKEEVNSVVQHEAGQVFARVLEDAGVYKNTPSGHEAFMRFVKSVGIN
What are the official names of this protein?
Galactose-1-phosphate uridylyltransferase 1, Gal-1-P uridylyltransferase 1, UDP-glucose--hexose-1-phosphate uridylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_AERHH
Sequence: MTPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGQAKLGELEFIVVDTGGIDGTEEGIELKMAEQSLLAIEEADVVLFMVDARAGLTAADQAIAEHLRKTHKKVFLVANKTDGIDGDSAVSEFYGLALGEVYQMAAAHGRGVLSLLELALAPHLETLVDAATQETAQDEEEEDFDEEALLRMVAAGELDTKEDTKETPFADLPIKFAIVGRPNVGKSTLTNRMLGEDRVIVYDMPGTTRDSVYIPMERDEQKYVIIDTAGVRRRGKVHETVEKFSVIKTLKAIEDANVCLLVIDAQETITDQDLSILGFVLNTGRSVVLVVNKWDGLDQKVKEDVKNELDRRLGFIDFARVHFISALHGSGVGHLFESIQEAYQSATRRTSTAMLTRIMQMAQEDHQPPMVNGRRVKLKYAHAGGYNPPRIVIHGNQLNDLPDSYKRYLINYFRKSLKIMGTPVRVEFQESANPFEGKKNTLTLSQERQRKRLLKAKAKK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: FMT_THEM4
Sequence: MRILFLGTPDFASVHLEFLMKNGFDVVAVISQPDKPKGRGKKILPTPVKEVALKYNIPVFQPKKLNKEGLKIIENLKPDIGIVVAYGKLLKPPFLNTLEFYNVHASLLPSYRGAAPIQRVLENGEKRTGITIFKIGEGMDDGPIALKKEVEVGEFETFGELYEKLLDLGKKALIEFLNNYPIELIPQEGKVSFAPKITKEDLKLDFSKDVTFVKNKIRAYDPLPGVRVLFKRKIVKLFGVFSVLENSSREIGKIISIDKEGALISCENGSVKVRYIQFPGKRKMTFFEAKNGCLIKEGECFDC
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: YIFL_ECO57
Sequence: MKNVFKALTVLLTLFSLTGCGLKGPLYFPPADKNAPPPTKPVETQTQSTVPDKNDRATGDGPSQVNY
What are the official names of this protein?
Uncharacterized lipoprotein YifL.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: CYSG_SHIBS
Sequence: MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTLVEGPFDESLLDTCWLAIAATDDDTLNQRVSEAAEARRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFTTMSERRRFWEKLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEHGMPGEMPVAIVENGTAVTQRVIDGTLTQLGELAQQMNSPSLIIIGRVVGLRDKLNWFSNH
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: H2A6_ORYSJ
Sequence: MDVGVGGKAAKKAVGRKLGGPKKKPVSRSVKAGLQFPVGRIGRYLKKGRYAQRVGTGAPVYLAAVLEYLAAEVLELAGNAARDNKKNRIIPRHVLLAIRNDEELGKLLAGVTIAHGGVLPNINPVLLPKKTAEKADKPAKASKDKAAKSPKKQARS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Probable histone H2A.6.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: AGUA_ASPCL
Sequence: MRSVITTLTLVASVGLAVAENGFDGWLRYAPVSCHGACQKSLPSHIVTLDPTESSPISVAGQEIQDGLQRMFKMHATVEPKGCSTRSSVIIGTLDAYNHACKDADPVPELEEDGFWLNTKDGKVQIIGQSERGALYGAYEYLSMLSQGNFAPVSYTTSPHAPIRWVNQWDNMDGSMEHGYGGLSIFFKDGVIPQDLSRVKQYARLLASIRINGIIVNNVNANASLLKPENMDGLARIADIFRPYGVKVGISLNFASPSTLGGLNTYDPLDESVISWWGGITDELYKRVPDMAGYLVKANSEGQPGPTTYNRTLAEGANLFARALKPHGGIVMFRAFVYDHHISEENWYNDRANAAVDFFKPLDGKFEENVVVQIKYGPIDFQVREPVSPLFANLYKTNTAIELQVTQEYLGQQSHLVYLPPLWQTILGFDLRVDGKPSPTRDIISGQRFNRPLGGWAAVVNVGTNTTWLGSHLALSNLYAYGRLAWEPTLDSQDILQDWIRMTFGLDRRVLDTITKMSMESWPAYENYSGNLGIQTLTDILYTHYGPNPASQDGNGWGQWTRADHEAIGMDRTIKNGTKFTGQYPAEVAQVYENIETTPDDLLLWFHHVPYTQRLQSGKTVIQHFYDAHYAGADTAQTFVSQWESLRGKIDPERYEHVLTRLIYQAGHSIVWRDAINEFYHNLSGIADEKQRVGHHPWRIEAEDMKLDGYVPYDVNPFETASNTKAIVTATNSTTGTASTQLDFKTGKYDLGINYYDFYGGKSQWTAYLNDRLVGQWQGNNEDVLSHELSVYLDGHSATRITFRDVKIHKGDRLKIVGKPDGMEPAPLDYVVLLPQGIVD
What is the function of this protein?
Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.  Releases 4-O-methylglucuronic acid from xylan (By similarity).
What are the official names of this protein?
Probable alpha-glucuronidase A, Alpha-glucosiduronase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 67 family.
What are the subcellular locations of this protein?
Secreted.
Protein: C_VSIVC
Sequence: MRLKHNGRKSPIMNCSKRTDRKSILSPLIFRQQMILIQNLNQKLKTIKACLYQTWKLSRLKALYRSL
What is the function of this protein?
May play a role in viral pathogenesis or transmission by insects vectors.
What are the official names of this protein?
Protein C'.
What is the protein family that this protein belongs to?
Belongs to the rhabdoviruses C protein family.
Protein: RF1_AERS4
Sequence: MNPSLIRKLEGLIERHEEVQAMLGEPGVASDQDRYRALTREYAQLEDIVHAFQRFRQAEENLEATKLMLEEDDADLREMAQEELPLAKSTLEEQEQALQVMLLPRDPKDDNNCYLEIRAGAGGDEAAIFAGDLFRMYSRYAERQGWRISIVSCNDGEHGGYKEVIAKVDGEHVYGRLKFESGGHRVQRVPETESQGRVHTSACTVAVLPEVPEAEQIEINANDLKIDTFRASGAGGQHVNKTDSAIRITHLPTGLVVECQDERSQHKNRAKAMSVLSARLQAAEDERHRAAEQSTRRNLVGSGDRSERIRTYNYPQGRLSEHRINLTLYRLGEIMEGDLDCIISPMIQEYQADQLASLAENS
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBS_RHIEC
Sequence: MKIKDYAVDTARAVAFLSRLPMPPALFNGYDGRLNRLVRAFPFAGLLIGFVPAVTLLLLLSLRTDPLVAALVALSVQALVTGALHEDGLADTADGIGGGSSREQSLIIMKDSRIGTYGAIALILSFAIRAAALAAIIRHSSPLAAALAIPAVAALSRGAIAWHWQRLPPAKPDGVAASNGQPNEAAMHFALVSAGLLAALLIWPPFGLRPLVAGLLVAGVAGFAFTVFIRRKLAGHTGDTLGATQQICEIATLCALATAL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1347_HALLT
Sequence: MELTWHGHSTWHVVVDDTELLIDPYFDNPKTDVDPEELDPDYLLLTHGHSDHIGDVDRYEGATVVATPELTGYIQENFGHENAVGGMGMNIGGTVECGDAWVTMVRADHSNGIDTGYGTSAGMPAGFVIGDKKPTQESDPDCTTFYHAGDTGLMSEMVDVIAPYLEPDAAALPTGDHFTMGPAGAGIAADWVGADVVFPMHYDTFQPIEIDTREFVNEVKAAGAAAEPVVLEGDETYVLENEFGSDGD
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Hlac_1347.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: MCR1_YEAST
Sequence: MFSRLSRSHSKALPIALGTVAIAAATAFYFANRNQHSFVFNESNKVFKGDDKWIDLPISKIEEESHDTRRFTFKLPTEDSEMGLVLASALFAKFVTPKGSNVVRPYTPVSDLSQKGHFQLVVKHYEGGKMTSHLFGLKPNDTVSFKGPIMKWKWQPNQFKSITLLGAGTGINPLYQLAHHIVENPNDKTKVNLLYGNKTPQDILLRKELDALKEKYPDKFNVTYFVDDKQDDQDFDGEISFISKDFIQEHVPGPKESTHLFVCGPPPFMNAYSGEKKSPKDQGELIGILNNLGYSKDQVFKF
What is the function of this protein?
The outer membrane form may mediate the reduction of outer membrane cytochrome b5 (PubMed:8001120).  The soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria (PubMed:8001120).  Involved in the reduction of D-erythroascorbyl free radicals (PubMed:11420140).  May play a minor role in complementing the function of CBR1 as a DPH3 reductase in the first step of diphthamide biosynthesis and tRNA Wobble base mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine) formation (PubMed:27694803).
What are the official names of this protein?
NADH-cytochrome b5 reductase 2, Mitochondrial cytochrome b reductase, p34/p32.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
[NADH-cytochrome b5 reductase p32 form]: Mitochondrion intermembrane space. SUBCELLULAR LOCATION: [NADH-cytochrome b5 reductase p34 form]: Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion intermembrane space.
Protein: TIG_RUBXD
Sequence: MTANVTKLEDNKVRLDVEVPPEAVREGVEAKLRELRKQVRVPGFRPGKAPRRVLETHLGRDYIYMEALQESLPAWYSRAVIDADIRPIDRPEIHFDDPLDEKKGFRFSATVEVRPEARLGEYKGLEVPKREVEVTEEQVEERLEELRGQFATLAAVEDRPVREGDFVILDFKGERMAGGELPGAEAEDYMLEVGRGELLEDFEKNLVGMKAGERKQFAVTFPMDYREESLRGQSVLFRVHVKEIKERDLPPLDDEFAKEASEFETLEELRAAIREQLEEAARRRAEGEFRARVLEAVAERAEVEVPEVMVEDKAEEMVRSFERSVSAQGIKPEDYYRIAGTGREEFKRQVRDDAADTVKKELVLDAVVAAEGIEADEEAVRHEIEHLAEDSGRSPEEVEKSLRENGTYALLREELARQKALDFLVEHARAVPMPPEDEQMPGSGEEPGGGEGVVEARVESAAETEAERDEEGESR
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.