PharMolix/UniProtQA huggingface dataset:
Protein: RADH_LENKE
Sequence: MTDRLKGKVAIVTGGTLGIGLAIADKFVEEGAKVVITGRHADVGEKAAKSIGGTDVIRFVQHDASDEAGWTKLFDTTEEAFGPVTTVVNNAGIAVSKSVEDTTTEEWRKLLSVNLDGVFFGTRLGIQRMKNKGLGASIINMSSIEGFVGDPTLGAYNASKGAVRIMSKSAALDCALKDYDVRVNTVHPGYIKTPLVDDLEGAEEMMSQRTKTPMGHIGEPNDIAWICVYLASDESKFATGAEFVVDGGYTAQ
What is the function of this protein?
NADP-dependent (R)-specific alcohol dehydrogenase (ADH) with a broad substrate specificity, able to catalyze in vitro the stereoselective reduction of several aliphatic and aromatic ketones as well as beta-keto esters to the corresponding enantiomerically pure alcohols.
What are the official names of this protein?
NADP-dependent (R)-specific alcohol dehydrogenase, (R)-specific ADH, Ketoreductase, KRED.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: AKIP1_MOUSE
Sequence: MEYCLAAAALNGVDRRSLQRSARLGREVLERAKRRAVDWHSPERSRGNVGVLYRQGPYQERWSVPGSQRLLGEREERCPTLSSSFGAMAEFMDYTSSQCGKYYLSMPEEGGATHVYRYHRRKPPEMHMYSDTGHSQEQRNCRGETSVGQESIYQTSEHSQESSWPTENISKDLYIEVYPGTYSVTVGSSALSKKTHVVAVDPGQSVDLVFPV
What is the function of this protein?
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA.  Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity).
What are the official names of this protein?
A-kinase-interacting protein 1, Breast cancer-associated gene 3 protein, PKA-interacting protein, Proline-rich protein BCA3.
What are the subcellular locations of this protein?
Nucleus. Note=Locates to punctate spots.
Protein: Y532_BUCBP
Sequence: MQLKIYSSNKNYIQRGTKAFTEVTIAFFLAGFSTFSTLYCVQPILFLFSKEFSLNPAQSSLSLSASTAMMAFGMLFTGPLSDSIGRKVVMSSSLFLASFCTFCCSNMNSWESIIFMRALTGLALSGVAAVAMTYLSEEMHPSVLSFSIGLYISGNTIGGFLGRFLSSLFSEYFSWNIALEFISFLAFTSAVLFVYLLPKSKNFCSSPLDLRKILLYFIFQWRDPVLSKLFFMGCILMGSFITLFNYVGYRLISQPFFLGQTTIGLLSIIYLIGVYSSPQAGVLIERYRKGVILTLALTMMIFGVLITQCNIVLLIIVGLTLFAAGFFAAHSVTSTWISQCSKINKGSTSSIYLFSYYLGSSIFGTFSGIFWITEKWLGISIFIITFLCIGILLSIRLLQYKNI
What are the official names of this protein?
Uncharacterized transporter bbp_532.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL25_TOLAT
Sequence: MSFTFQTEVRADLGKGASRRLRRAEQVPAILYGAGQEAVSLVLDHNKVITAQQEAAFYSEVLTLVVDGKEVKVKVAAVQRHPVKPKVVHLDFIRA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: APAH_SALTY
Sequence: MATYLIGDVHGCYDELIALLQQVEFTPDTDTLWLTGDLVARGPGSLDVLRYVKSLGNSVRLVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQVDEEKKLVMAHAGITPQWDLQTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELSGLARLRFITNAFTRMRYCFPNGQLDMYSKASPENAPAPLKPWFAIPGPVSEAYSIAFGHWASLEGKGTPEGIYALDTGCCWGGELTCLRWEDKQYFVQPSNRQMDMGEGEAVNA
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: ADPRM_ORYSJ
Sequence: MMAVTNGVIHASSREPLFSFGVIADVQYADIPDGRSFLGVPRYYRHSISVLQRAVSTWNKQHNIKFSINFGDIIDGYCPKDKSLWAVQKVLDEFEKFDGPTYHMFGNHCLYNLPRGKLVSLLKMPTDSDRAYYDFSPCPEYRFVVLDAYDFSALGWPRDHPVTAEAMKFLEEKNPNSDKNSPDGLVGVDRRFVMFNGGVGKEQLSWLNDVLQDASARRQNVILCSHLPMDPGSASFAALMWNYDEVMAIVRQYKCVKACFAGHDHKGGHSVDSHGVHHRTLEAALECPPGTSAFGHIEVYPDKLLLVGSDKMADTEMCFEP
What is the function of this protein?
Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose.
What are the official names of this protein?
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase, ADPRibase-Mn, CDP-choline phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the ADPRibase-Mn family.
Protein: NPD2_CALS4
Sequence: MFFMDSKNLFKKAAELIKSSQKTMVLTGAGISTESGIPDFRSPGTGLWENMDPTEVLSTKVLFNSPEEFYRVGFKILSSMRNAEPNEAHYILSEMEKEGIIAGVITQNIDNLHQKAGSKKVYEVHGNTREGSCLRCGEKVSFELLEEKVAKEEIPPRCDRCGGMLRPDVVLFGDPMPHAFDLALKEVQESDLLIVIGSSLVVAPVNFLPGMVDGLIIINATETPYDYKADVVIREKASYALRNIWNLIKS
What is the function of this protein?
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
What are the official names of this protein?
NAD-dependent protein deacetylase 2, Regulatory protein SIR2 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class U subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1551_STAAS
Sequence: MTEHNHDSQLEINNEEELLTLFDEEGNEVLYRKVLEFYHPEFKKEYVILAEEGAQSDEDDMIELVPMINEPDESGDGGKLVPIETDEEWDMIEEVVNTEMEE
What are the official names of this protein?
UPF0473 protein SAS1551.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: ATPE_BURM7
Sequence: MATIKVDVVSAEEQIFSGQAKFVALPGEAGELGILPGHTPLITRIRPGAVRIESESGDEEFVFVAGGILEVQPGAVTVLADTAIRGKDLDAAKAEEARKRAEETLQNAKSDIDLAKAQSELATAMAQLEAIQRLAKIRGKH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YP170_YEAST
Sequence: MTERITTPNADRTVQHHALPVDTTGLIFFAVFASSFVLYRRGSCFESYLFFSFPLSYFSNNRKKSRVQSDKQFFSVFKKNDPEQQHLYYAALMQFLTQLVESPTLFCVCTQ
What are the official names of this protein?
Putative uncharacterized membrane protein YPR170C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: OSTA_LEUER
Sequence: MDVAHPEEVTRFSPDILMEKFNVSEACFLPPPISIQLILQLTWLDIGVFAALTAMTVLTIAIYLEIVCYLMDKVKCPIKRKTLMWNSAAPTVIAITSCLGLWVPRAIMFVDMAAAMYFGVGFYLMLLIIVQGYGGEEAMLQHLATHTIRISTGPCCCCCPCLPHIHLTRQKYKIFVLGAFQVAFLRPALFLLGVVLWTNGLYDPDDWSSTSIFLWLNLFLGVSTILGLWPVNVLFRHSKVLMADQKLTCKFALFQAILILSSLQNSIIGTLAGAGHIGCAPPYSARTRGQQMNNQLLIIEMFFVGILTRISYRKRDDRPGHRHVGEVQQIVRECDQPAIADQQADHSSISHI
What is the function of this protein?
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for the translocation of bile acids (such as taurocholate), steroids (such as estrone sulfate), and eicosanoids (such as prostaglandin E2).
What are the official names of this protein?
Organic solute transporter subunit alpha, OST-alpha, Solute carrier family 51 subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the OST-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: REV_HV112
Sequence: MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: FLAV_TREPA
Sequence: MAKVAVIFWSGTGHTETMARCIVEGLNVGGAKADLFSVMDFDVGTFDSYDRFAFGCSAAGSEELESSEFEPFFTSIEGRLSGKKVALFGSYEWAGEGEGGEWMVNWVERCKAAGADVFEGKGEIAYDDPSEEAQASCKAFGERFAR
What is the function of this protein?
Low-potential electron donor to a number of redox enzymes.
What are the official names of this protein?
Flavodoxin.
What is the protein family that this protein belongs to?
Belongs to the flavodoxin family.
Protein: VINC_XENLA
Sequence: KWSSKSPGNYDYPAPQGREAVISEVEQAQEEEEEEASVEFALSSDIEDDYEPELLLVPEGQPVNQPMLAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGNKRALIQCAKDIAKASDEVTKLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWARKTPWYQ
What is the function of this protein?
Involved in cell adhesion.  May be involved in the attachment of the actin-based microfilaments to the plasma membrane.
What are the official names of this protein?
Vinculin, Metavinculin.
What is the protein family that this protein belongs to?
Belongs to the vinculin/alpha-catenin family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, adherens junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Protein: KTI12_HUMAN
Sequence: MPLVVFCGLPYSGKSRRAEELRVALAAEGRAVYVVDDAAVLGAEDPAVYGDSAREKALRGALRASVERRLSRHDVVILDSLNYIKGFRYELYCLARAARTPLCLVYCVRPGGPIAGPQVAGANENPGRNVSVSWRPRAEEDGRAQAAGSSVLRELHTADSVVNGSAQADVPKELEREESGAAESPALVTPDSEKSAKHGSGAFYSPELLEALTLRFEAPDSRNRWDRPLFTLVGLEEPLPLAGIRSALFENRAPPPHQSTQSQPLASGSFLHQLDQVTSQVLAGLMEAQKSAVPGDLLTLPGTTEHLRFTRPLTMAELSRLRRQFISYTKMHPNNENLPQLANMFLQYLSQSLH
What are the official names of this protein?
Protein KTI12 homolog.
What is the protein family that this protein belongs to?
Belongs to the KTI12 family.
Protein: TSN11_BOVIN
Sequence: MAHYKVEQDDWLTVYLKYLLFIFNFFFWVGGAAVMAVGVWTLVEKSGYLGVLASSTFAASAYILIFAGALVMVTGFLGFGAVIREDRGCLSAYFCLLLAIFLVELVAGVLAHVYYQRLSDELKQHLTRTLAENYRQPGAAEITASVDRLQQDFKCCGSNSSADWLQSSYILSPEAEGRRVPDSCCKTVVARCGQRAHPSNIYKVEGGCISKLEQFLADHLLLMGAVGIGVACLQICGMILTCGLHRRLQLHFY
What are the official names of this protein?
Tetraspanin-11, Tspan-11.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: OSTP_PIG
Sequence: MRIAVIAFCLWGFASALPVKQTNSGSSEEKLLSNKYTDAVATLLKPDPSQKQTFLAPQNTISSEETDDFKQETLPSKSNESPEQTDDVDDDDDEDHVDSRDTDSEEADHADDADRSDESHHSDESDELVTDFPTDTPATDVTPAVPTGDPNDGRGDSVVYGLRSKSKKFRRSEAQQLDATEEDLTSHVESEETDGTPKAILVAQRLHVASDLDSQEKDSQETSQPDDRSVETRSQEQSKEYTIKTYDGSNEHSNVIESQENPKVSQEFHSHEDKLVPDSKSEEDKHLKLRVSHELESASSEIN
What is the function of this protein?
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
What are the official names of this protein?
Osteopontin, Bone sialoprotein 1, Secreted phosphoprotein 1, SPP-1.
What is the protein family that this protein belongs to?
Belongs to the osteopontin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TARD_BRADU
Sequence: MSVRIVDVREITKPISSPIRNAYIDFTKMTTSLVAVVTDVVREGKRVVGYGFNSNGRYGQGGLIRERFASRILEADPKKLLNEAGDNLDPDKVWAAMMINEKPGGHGERSVAVGTIDMAVWDAVAKIAGKPLFRLLAERHGVKANPRVFVYAAGGYYYPGKGLSMLRGEMRGYLDRGYNVVKMKIGGAPIEEDRMRIEAVLEEIGKDAQLAVDANGRFNLETGIAYAKMLRDYPLFWYEEVGDPLDYALQAALAEFYPGPMATGENLFSHQDARNLLRYGGMRPDRDWLQFDCALSYGLCEYQRTLEVLKTHGWSPSRCIPHGGHQMSLNIAAGLGLGGNESYPDLFQPYGGFPDGVRVENGHITMPDLPGIGFEGKSDLYKEMKALAE
What is the function of this protein?
Catalyzes the dehydration of D-tartrate to oxaloacetate.
What are the official names of this protein?
D(-)-tartrate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family.
Protein: URED2_STRGG
Sequence: MAALASVPDTLAPGSPAKVGILDLAFAVRGGRTELVERYQKTPLQIMRPLWIDPEQPGMSYVYIMATGAGVAQADRYRMDFRCGPDTQVHLTTQAATKIFRMEHDYASQRVHLSAEAGSYVEYLPDPLIPFKGSRFYQRTEVTVAPGATVVVADTLTAGRLARGERHAYRVLATDLHISRPDGTLLAIDTLRLVPGRRGGGVLGPAVFAGHDLVASLFAVTDRVPATVLADALHDALAGLGLLHGVSVLPRDCGAWVRVLDDSPIRIAGAQEAVRQAVRRLLTGRPAPDLRKP
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD 2.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_MESH7
Sequence: MRFVDYVSIEVVAGKGGDGIISFRREAHVDKGGPDGGDGGWGGSIYFVGDSGMNTLLPFYQTKKIFGYNGENGRPKRQTGANGKDIFIKVPLGTQVFLKKSLICDIILEKKYLIAKGGRGGLGNFHFRNSKNKAPRISENGELGQNFYLDLQLKVMADIGLVGKPNAGKSTLLSLISNSKPKIANYEFTTLVPQLGVVKIYENSFVTADLPGLIQGASSGKGMGIIFLKHIERCRAIVHVIDFGSDNKNPIKDFIEIKSELEKFNKKLLDLNQIVIANKCDLPNFQFNLANFKRKFPKIKIIKSSLISAKQNEINIIKEKMFGLLGENQKKLEIQEINTSKIEFNLKAPFLIKSRNNGFFEITGELIQKIIQKIPLNSQENILRFNAKVKKIGLWDELIKKGIKPGDLVRIYEFEFHWN
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y073_NPVOP
Sequence: MTPQAALLDVQSEALHLASEVNAFLTTPNSTDFELILTKLSFRARAISFDEVAEPRRSFYESLKLNCIVCINVLIDIVLLKINM
What are the official names of this protein?
Uncharacterized 9.4 kDa protein.
Protein: TRPD_FLAPJ
Sequence: MKNILNRLINHETLSKQEAKNMLVNISNGSYNPSQIASFLTVYMMRNITINELAGFREALLELCIPIDLSAYNTIDLCGTGGDGKDTFNISTLASFVTAGAGIKVAKHGNYGVSSISGSSNVMENLGIKFSNDPIFLEKCIDQAGICVLHAPLFHPAMKNVAPIRKELAVKTFFNMLGPMVNPSFPKNQLVGVFNLELARMYSYLYQNTKTNYTILHSLDGYDEISLTGNTKTITNKMEGMLKPEDFGVNLLSQTDIQGGTTIQESAQMFVTILSGKGTEAQNNVVCANAGMAIATVNNLNPIQGFELAKESLLSGKGLETLKKLQQLSL
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RL24_CLOBK
Sequence: MSKIHVRKKDTVVVISGKDKGKIGEVLSVLPKKGKVIVKDVNVVTKHQKPNRENMQGGIIHKEAPIFSSKVMLYCDKCKSATRISNKILEDGTKVRVCKKCGETF
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: FPPS2_ARTSI
Sequence: MSIDLKSRFLQVYDSLKSDLIHDPAFEFDDDSRNWVERMLDYNVPGGKLNRGLSVVDSYKLLKQEELTEDEVFLACALGWCIEWLQAYFLVLDDIMDESHTRRGQPCWFRLPKVGMIAVNDGVVLRNHIPRILKKHFRGKAYYADLLDLFNEVEFQTASGQMIDLITTLFGQKELSKYSLSTHQRIVKFKTAYYSFYLPVACALLMFGENLDDHVQVKDVLVEMGTYFQVQDDYLDCFGSPEVIGKIGTDIEDFKCSWLVVKALELADEQQKKLLNENYGRKDPASVAKVKELYHTLNLQGVFEDYENKSHEKIIKSIETHPSKAVQEVLKSFLGKIFKRQK
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl pyrophosphate (IPP) with the allylic pyrophosphates, dimethylallyl pyrophosphate (DMAPP), and then with the resultant geranylpyrophosphate (GPP) to the ultimate product farnesyl pyrophosphate (FPP).  Has a greater affinity for DMAPP versus GPP.
What are the official names of this protein?
Farnesyl diphosphate synthase 2.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: DNAJ_EHRRG
Sequence: MSKSDYYDLLGLSKNATPEEIKKAYRKMALKYHPDKNPGDKAAEEKFKELSEAYDVLIDKDKRAAYDRYGHSAFSDGSGRGGFDFNSGFSTDFSDIFNDLFGGGFRGGRSSSKRQDGGTVGSDLRLDIEITLEDSFNGTKVPINYVTHVKCSSCSGSGSEGSVKSVQCNTCHGAGNTRTQQGFFTIERTCHVCNGEGEIIKNKCKKCSGSGRVRDEVNLLVTVPKGIESGDKIRLNGKGEAGYRGAQSGDLYVYPNIKKHKFFTRNGADLYCNVPIKMILATLGGHIEMPSIDGTWTKVKVPEGSQNGDKLRLKEKGMPVINSSRRGDMYIQITVETPINLTKQQKELLKKFDEEPNTVECNPQSTGFFQKVKSFWNDIRSS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS1_NEMVE
Sequence: MAAGFRTNVWDPVLIISQIIAIQCTFYISLGVWVLIVDYWSGSIHSLDQFFAYKELDISSLKGKLLMIAFCLNSLTGAMALWFIVKRAKQCLDFTTTAHIVHLVFCCIYAGFPFSWTWWLLNIICLALMAVIGEFVCMKTELKAIKVSAGSSGKNSV
What is the function of this protein?
Involved in protein trafficking.
What are the official names of this protein?
Protein SYS1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SYS1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: METK_SHEFN
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEVTTSAWVDIEEITRKTVREIGYTNSDMGFDADSCAVLNAIGKQSPDINQGVDRSDPAEQGAGDQGLMFGYASNETDVLMPAPITYAHKLVKRQSEVRKDGTLPWLRPDAKSQVTFAYDDGKIIGIDAIVLSTQHREDVTQADLIEAVMETIIKPVLPAQWLNKDTKYFINPTGRFVIGGPVGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCELQVSYAIGVAEPTSISIETFGTGKVSEEVLIKLVRQHFELRPYGLTAMLDLARPIYQQTAAYGHFGRDIFPWEATDKAEALRADAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_FRASN
Sequence: MGQKVNPHGFRLGITSEFTSRWYADKQYKAYVGEDVKIRKMMSKGMERAGISRVDIERTQGRLRVDIHTARPGIVIGRRGAEADRIRGDLEKLTGKQVQLNILEVKNPEIDAQLVAQGVAEQLSSRVSFRRAMRKAMQSAMKSGAKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGFYEARTNFGRIGVKVWIYKGDIVQSRAEREAQEALLRQQRRERPRRGPRSGSSGTTQGGTDAGRAAARAGDRRGRGGSGGGGGSAEKASAAEKAPAEKPATESAAVEGTPVETPAVTPETTAAPAAVTTAEAQGAPEKAEG
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RIMM_OLEA2
Sequence: MDKYVQIGLITKPHGLRGEVCVVSYADSPFLMQERIFLQAGKGPCVPYRVRSSRRHSGTELLLLEGIDDRNAAEKLRQHKVLIPHAELPELEDDEVYIEDILGFTVVLDEDGSTLGTLTAFSAPTPEQEVWEITTPDGKEVLFPAAEEFVAEIDVDSETIRITPPPGLLEIYLSGS
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAZG_ECO57
Sequence: MNQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDICAAISDKLERRHPHVFADSSAENSSEVLARWEQIKTEERAQKAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLGPVVDKVYEEIDEVMYEARQAVVDQAKLEEEMGDLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMTGVDLETMEEVWQQVKRQEIDL
What is the function of this protein?
Involved in the regulation of bacterial cell survival under conditions of nutritional stress.  Regulates the MazE-MazF toxin-antitoxin (TA) system that mediates programmed cell death (PCD).  This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF.  Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA (By similarity).
What are the official names of this protein?
Nucleoside triphosphate pyrophosphohydrolase, NTP-PPase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside triphosphate pyrophosphohydrolase family.
Protein: SYC_BUCCC
Sequence: MLRIFNTLTKKKEIFDFLLNKKINIYVCGVTTYDFCHIGHARTFIIFDIIIRYLQYLGYNTFYIRNITDIDDKIINKAKINNESIHILVNRMIKLMHKDFLSLNLIKPDQEPRVTQHISNIISSIKLLLKNNYAYVSDNKDILFKLNNFKEYGFLSNRMFNCSEKNFTTISKEKNYINNINDFVLWKHSNQLSIDTCTNWSSPWGAGRPGWHIECSSIINNFFKDGVVDIHGGGIDLLFPHHENEIAQLKSMNNSFSVNFWIHSGMVINKNHKMSKSFSNSVSIQYLLKKYDSEIIRWYFLATHYRHPLYYSEKNLLMMKNIFIKIYRSLLDCVVTINTKIDYEYHLRNKIKRKFFSAMNDDFNTPKACSILQKISKLIYKNKKNNTYLANILASDLVYLGKILGLFQNDPKNFFLKDNFCNKSTDLLIIVEKLFHMRNFYRSKKQWNLSDIIRKKLFCLGVIVEDNSYSSYYRFI
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.