PharMolix/UniProtQA huggingface dataset:
Protein: KPRS_NOSS1
Sequence: MLSSATFKLQPTATGLTENHRLRLFSGSSNVQLSQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPCCQPVNDHLMELLIMVDACRRASARQVTAVIPYYGYARADRKTAGRESITAKLVANLITQAGANRVLAMDLHAAQIQGYFDIPFDHVYGSPVLLDYLTSKQLHDIVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAVLVDDMIDTGGTIAAGAKLLREEGARQVYACATHAVFSPPAVERLSSGLFEEVIVTNTIPIPESDRFPQLVVLSVANLLGETIWRIHEDTSISSMFR
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_SHESR
Sequence: MGDNKNNGDSGKLLYCSFCGKSQHEVRKLIAGPSVYVCDECVELCNDIIREEIKEISPKRDNDKLPTPHELRAHLDDYVIGQDRAKKVLSVAVYNHYKRLRNSSPKDGVELGKSNILLIGPTGSGKTLLAETLARSLNVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLEKVIEQRAHVGSGIGFGAQVKGEKDKATISQTLSQVEPEDLVKYGLIPEFIGRLPVVATLTELDEEALVQILSEPKNALTKQYNALFEMEGVELEFREDALKAIAHKAMSRKTGARGLRSIVEGILLDTMYDIPSIEGVVKAVVDESVVNGESAPILIYERNDAQAASGEQ
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: SURE_BORPE
Sequence: MRILVSNDDGYNAPGLEALVEALSGLGELTVVAPETNHSGASNSLTLNRPLTVRTAANGFIYVNGTPSDCVHVALTGLMDARPDLVVSGINNGANMGDDTLYSGTVAAASEGYLFGIPSIAFSLIEKGWQHIESAARAARQVVERQIAQPLAAPVLLNVNIPNRRYEDMKGYAVTRLGKRHPSEPVVRTTTPYGDTVYWVGPVGLAADATPGTDFHATAQGQVSVTPLRLDLTQHSQLDDVRNWAEPLCVNA
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIAL_BOVIN
Sequence: MKTVLILLSILGMACALSMKNLNRRAKLEDSEENGVFKYRPQYYVYKHGYFYPALKRFAVQSSSDSSEENGNGDSSEEEEEEEETSNEEGNNGGNEDSDENEDEESEAENTTLSTTTLGYGEITPGTGDIGLAAIWLPRKAGATGKKATKEDESDEEEEEEEEEENEAEVDDNEQGINGTSSNSTEVDNGHGSSGGDNGEEDGEEESVTEANTEGITVAGETTTSPNGGFKPTTPHQEVYGTTPPPFGKITTPGEYEQTGTNEYDNGYEIYESENGDPRGDNYRAYEDEYSYYKGRGYDSYDGQDYYSHQ
What is the function of this protein?
Binds tightly to hydroxyapatite.  Appears to form an integral part of the mineralized matrix.  Probably important to cell-matrix interaction.  Promotes Arg-Gly-Asp-dependent cell attachment (By similarity).
What are the official names of this protein?
Bone sialoprotein 2, Bone sialoprotein II, BSP II, Cell-binding sialoprotein, Integrin-binding sialoprotein.
What are the subcellular locations of this protein?
Secreted.
Protein: RS3_MYCUA
Sequence: MGQKINPHGFRLGITTDWKSRWYADKQYADYVKEDVAIRRLLSSGLERAGIADVEIERTRDRVRVDIHTARPGIVIGRRGTEADRIRADLEKLTGKQVQLNILEVKNPESQAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRQPNVKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGLYEAKTTFGRIGVKVWIYKGDIVGGKRELAAAVPAGADRPRRERPAGSRPRRSGASGTTATGTEAGRAVGSEEPAAAESATTPEAQSTES
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: TRMD_RICRS
Sequence: MSILHATILTVFPEMFPGTLGHSLAGQALNKNIWSYDVINIRDFGLTKHKNIDDEAYGGGNGLIMRPDVLGSSIDHALALNPNAEMYYPSPRGRVFTQSFAKEMLKNKNLIFLCGRYEGIDERVIEEYNVKEISVGDYILSGGEIPTLTILDCLIRLLPGVLMNQNTLSSESFEEDGEFKGGLECSLYTRPEIWRNRAVPSVLLSGNHRLINEWKKAQSHMITKLRRPELLKDL
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_IDILO
Sequence: MTAPALKNDRYLRALAKQPVDRTPVWMMRQAGRYLPEYKEVRGQAGDFMSLCRNTELACEVTMQPLRRFDLDAAILFSDILTIPDAMGLGLYFEAGEGPKFKDPVRSMAAIKNLAVPDMEDELGYVMDAVRAIRRELNGSVPLIGFSGSPWTLATYMVEGGSTKNFSKVKQLMFADPEAMHTLLNVLAESVTQYLNAQIAAGAQSVMIFDTWGGVLSPRDYKAFSLAYMEKIVAGLTREADGRKVPVTLFTKNGGQWLEAMAASGADALGVDWTTDLSDARARVGGQVALQGNMDPSVLYAKPARIEEEVQSILQSYGSGTGHVFNLGHGIHPEVDPEHAAAFIEAIHKYSPAFHSND
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_CLOB1
Sequence: MITKRIIPCLDVDMGRVVKGVNFVNLKDVGDPVEIAEFYNKEGADEIVFLDISATHEGRATMIDVVRKTAEKLFIPLTVGGGIKNINDFRDILRAGADKISVNSSAIRNPKLIKKAAECFGSQCVVVAIDGKKRKDKDGWNVFINGGRIDTGLDAIEWARKVEKLGAGEILLTSMDADGTKEGYDLEFTNEVSKAVNIPVIASGGCGKLKHFGEIFEKSSADAALAASLFHFKELSIKEVKNYLKKEGFSVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR12_HELAN
Sequence: MPTIKQLIRNTRQPIRNVTKSPALRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNSQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSSAL
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PHNC_ANADE
Sequence: MPQRPEAARAGPVAGPDAASKPAPGPALTLRGAGRAYGPVRALRPLTLEIRRGERVALLGPSGAGKSTLLRLLDTSLAPSEGTVEVLGQPVADTDARRLRALRARIGTVHQQLLLVPQATAMQNVVAGRLGRTSLARTLAALVSRREAARVRAVLDEVGIGDKIFERVDRLSGGEQQRVAIARTLYQDPELILADEPLASVDPARAADIAALLARAFAGRTLVVSTHRIEPLLAHVDRVVALREGALAFDKPAAALTLRDLGELYEARRGAADPARAPAARPPSDPVVAPGGTLRIGASSTPGEHLLPSIVRAFARAYPGTRVSLSLSDSAAVTAAVRDGALDLGFVGARDDDPALAYEDVARDEIVLVAAPVLELPPEPITLEVAARLPRVDREPGSGTRAVVEQHLANMGAALDPAAVVLEAGALVALKAAVVSGMGVAFVSRRAVEDDLRGGHVRTVRVEGLSIPRHVFAVLRRSPVPSAAARAFLEVARAEVPP
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL4_HAEDU
Sequence: MELQVVGANALTVSETTFGREFNEALIHQVVVAYAAGARQGSRAQKTRAEVSGSGKKPWRQKGTGRARSGDIKSPIWRSGGTTFAAKPQDHSQKVNKKMYRGAIKSILSELVRQERLVVVEKFEVEAPKTKFLVQKLKDLALNDALIITASLDENLFLAARNLYKVDVRDVQGIDPVSLIAFDKVVITTDAVKQIEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: FLGH_BURO1
Sequence: MKQVRLPSSATVRAACAVAVAALAGCAQIPRDPIIQQPMTAQPPMPMSMQAPGSIYNPGYAGRPLFEDQRPRNIGDILTIMIAENINATKSSGANTNRQGNTDFNVPTAGFLGGLFAKANLSATGANKFAATGGASAANTFNGTITVTVTNVLPNGNLVVSGEKQMLINQGNEFVRFSGVVNPNTISGANSVYSTQVADAKIEYSSKGYINEAETMGWLQRFFLNIAPW
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
Protein: YEGS_ECO27
Sequence: MAEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAVRFVEEARKLGVATVIAGGGDGTINEVSTALIQCEGDDIPALGILPLGTANDFATSVGIPEALDKALKLAIAGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGGVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEIIPTLVSTLKSDEDNPNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y5128_PARPJ
Sequence: MNDTSRTTAVCEPGCSNGVTRRAQAPVGTSFKHEHLSSILADGLKDGFFEVHAENYMGAGGPPHRALAAIREAYPISLHGVCMSIGGPGALDLTHLSRFRDLVTRYEPVLVSEHLAWSSHGGTFFNDLLPLPYTKATLEHVCEHISQVQDAIKRPLLLENPSTYVAFASSTLSETEFIRAVVQHTGCGLLLDLNNVFVSATNHGFSAEAYLEGLPLEQVGEIHLAGHSEQRDDENELLLIDSHDCAISDPVWHLYRDLVARIGPTPTLIEWDSKLPAWPVLRAQALSARHITAEEDVSLAEEVSHAG
What are the official names of this protein?
UPF0276 protein Bphyt_5128.
What is the protein family that this protein belongs to?
Belongs to the UPF0276 family.
Protein: ADM2_MOUSE
Sequence: MAQLLMVTVTLGCISLLYLLPGTLSGSLGKGLRHSRPREPPAKIPSSNLQPGHPSLQPVVWKSRRHAPQPQGRGNRALAMVHLPQGGGSRHPGPQRPTGSRRPHAQLLRVGCVLGTCQVQNLSHRLWQLVRPAGRRDSAPVDPSSPHSYG
What is the function of this protein?
May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes.  Activates the cAMP-dependent pathway.
What are the official names of this protein?
Protein ADM2, Intermedin.
What is the protein family that this protein belongs to?
Belongs to the adrenomedullin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMH_BIFLB
Sequence: MTDFSQIHKPVLLQECVDLVTPALHASDSVAVDCTLGLAGHTIAFLKAAPNATVIGIDRDEEALDKATARIAQEGLSARFVPVHAAFDQFDEVLRAQGVSRVQAVFMDLGLSSLQIDERERGFSYAHDAPLDMRMDTSQALTAREILATYDADRLAHIFKEYGEERFSKPIAKRIVQQRQSSPLETSSQLTALVDAVIPAARRGSGNPAKRVFQALRIEVNGELDKLRRTLPQIGLHLAVGGRLVVESYHSLEDRTVKNFMAQGLRVDAPADMPVIPPDMQPFFKALTKGAVKADAGEIAYNPRSASVRLRAVELTRPLPQRWVHAFELESQGSEDGVRGAHGHRRRTQARRG
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNNCA_HOMAM
Sequence: MDSLDEEQIGALQKAFDSFDTDSKGFITPETVGVILRMMGVKISEKNLQEVIAETDEDGSGELEFEEFVELAAKFLIEEDEEALKTELREAFRVYDKEGNGYITTDVLKEILRELDNRLTEEDLDSIIEEVDEDGSGTLDFNEFMEMMNG
What is the function of this protein?
Troponin is the central regulatory protein of striated muscle contraction.  Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.  The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
What are the official names of this protein?
Troponin C, isoform 2A.
What is the protein family that this protein belongs to?
Belongs to the troponin C family.
Protein: NTPPA_BACLD
Sequence: MTRQLILASQSPRRKELLDLLQIPYSIVTSNAEEKLIRNFSPAENVKWLAEQKVRAVAEQYPDAVVLGADTIVYYDGAYLGKPKDAEDAERMLSMLSGQTHSVLTGVCIKDGERCETFFEETEVSFWPLEEKEISAYIATGEPFDKAGSYGIQGKGALFVKQIKGDYYTVVGLPISKTMRMLKTFDLHSF
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GROA_RAT
Sequence: MVSATRSLLCAALPVLATSRQATGAPVANELRCQCLQTVAGIHFKNIQSLKVMPPGPHCTQTEVIATLKNGREACLDPEAPMVQKIVQKMLKGVPK
What is the function of this protein?
Has chemotactic activity for neutrophils.  Contributes to neutrophil activation during inflammation.
What are the official names of this protein?
Growth-regulated alpha protein, C-X-C motif chemokine 1, Cytokine-induced neutrophil chemoattractant 1, CINC-1, Platelet-derived growth factor-inducible protein KC.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: IL1B_TRIVU
Sequence: MAMVPEITCDEVDFYRDDDDRQFYEADGPNQKKGYFQYPDLCSKESLLEEDGIQLKFTTQPHQFHQTVMVIVAIEKMKHLNGLSSQFFQDNDLMNIFTNIFQEEPITFKNCDIYESDSSFRLVSSQDCTIQDINQKCLALSKASELRALHLNGRNISQQVIFSMKYLLGDIGSQKTHVVLCIKKNNLYLSCVRRGEKPILQLEQIANFPSINVEKRFIFNKVEINNTTEFESAEYPNWYISTSQMDEQPVFLGNIRGGKDITDFILADF
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Promotes Th17 differentiation of T-cells.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.  Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta, IL-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: ATOSB_PONAB
Sequence: MRHVQAEPSPSSEPEAGPSQPPVRQGALQGGLLMGYSPAGGATSPGVYQVSIFSPPAGTSEPHRALKRQAPPTEGPRELKRGPGLGAREGLPPEEPSTVGLLGPEGLGLGLGVASQHFSHRGLCVVEQRSSVTSSWTSGAWSPPCPPSNASCNTLHTRDWASPDPGGQGSLGESPGPAPPGQLHTLDTDLHSLAQIGGKSPVAGVGNGGSLWPRESPGTANGHSPEHTPPGPGPPGPCPTKRRLLPAGEAPDVSSEEEGPAPRRRRGSLGHPTAANSSDAKATPFWSHLLPGPKEPVLDPTDCGPMGRRLKGARRLKLSPLRSLRKGPGLLSPPSASPVPTPAVSRTLLGSFEESLLRGRFAPSGHIEGFTAEIGASGSYCPQHVTLPVTVTFFDVSEQNAPAPFLGIVDLNPLGRKGYSVPKVGTIQVTLFNPNQTVVKMFLVTFDFSDMPAAHMTFLRHRLFLVPVGEEGNANPTHRLLCYLLHLRFRSSRSGRLSLHGDIRLLFSRRSLELDTGLPYELQAVTEAPHNPRYSPLP
What is the function of this protein?
Transcription regulator that may syncronize transcriptional and translational programs.
What are the official names of this protein?
Atos homolog protein B.
What is the protein family that this protein belongs to?
Belongs to the ATOS family.
Protein: SNPC5_HUMAN
Sequence: MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRRGDEMLSSHTVPEQSHDMLVHVDNEASINQTTLELSTKSHVTEEEEEEEEEESDS
What is the function of this protein?
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes.  Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes.  Recruits TBP and BRF2 to the U6 snRNA TATA box.
What are the official names of this protein?
snRNA-activating protein complex subunit 5, SNAPc subunit 5, Small nuclear RNA-activating complex polypeptide 5, snRNA-activating protein complex 19 kDa subunit, SNAPc 19 kDa subunit.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y740_STRP3
Sequence: MSTHLRKLPGLLLCLLLALPAWYLGRLFPIIGAPVFAILLGMLLALFYHHRDKTKEGISFTSKYILQTAVVLLGFGLNLTQVMAVGMQSLPIIISTIATALLVAYGLQKWLRLDVNTATLVGIGSSICGGSAIAATAPVIKAKDDEVAKAISVIFLFNMLAALLFPSLGQLLGLSNEGFAIFAGTAVNDTSSVTATATAWDALHHSNTLDGATIVKLTRTLAILPITLGLSLYRAKKEHDIVTEENFSLRKSFPRFILFFLLASLITTLMTSLGVSADSFHSLKTLSKFFIVMAMAAIGLNTNLVKLIKTGGQAILLGSICWVAITLVSLAMQLSLGIW
What are the official names of this protein?
UPF0324 membrane protein SpyM3_0740.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNPA_VIBVY
Sequence: MNTYAFNRELRLLTPEHYQNVFQQAHRAGSPHFTIIARNNNLSHPRLGLAVPKKQIKTAVGRNRFKRLARESFRNTQHQLPNKDFVVIAKKSAQDLSNEELFKLFDKLWHRLSRPSRG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: TRPA_VIBVY
Sequence: MDRYQATFERLAAQKQGAFVPFVTVCDPNPELSLKIMDTLVQAGADALELGIPFSDPLADGPTIQGANIRALDSGATPDICFDLIGQIRAKYPDLPIGLLMYANLVYSRGIENFYQRCAQAGIDSVLIADVPTNESAEFVAAAEKFGVHPIFIAPPTASDETLKQVSQLGGGYTYLLSRAGVTGAETKANMPVGDMLAKLEQFNAPPALLGFGISEPEQVKQAIDAGAAGAISGSAVVKIIESHLNEPDAMLTALANFVSSMKSATQK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: OMCB_CHLCV
Sequence: MSKLFRRVVTVLALTSMASSFASGKIEAAAAESLATRFIASAENSDDNISQRKAKKVRFGRNKYQKQEQKNNGPYCDKEFYPCQDGSCQSSVDTKQEPCYGKMYCVRVSDDSNVEISQAVPEYATVGSPYPIEILAVGKRDCVNVVITQQLPCEVEFISSDPATTPTSDSKLIWTIDRLGQGERCKITVWVKPLKEGCCFTAATVCACPELRSYTKCGQPAICIKQEGPECACLRCPVCYKIEVTNTGSAIARGVVVDNPVPDGYSHPSGQRVLSFNLGDMRPGDTKCFTVEFCPQKRGKITNVATVSYCGGHKCSANVTTVINEPCVQVNISGNDWSYVCKPVEYTIVVSNPGDLKLYDVVIEDLIPSGITILEAPGAEICCNKAVWCIKEMCPGETLQFKVVAKAQTPGKFTNQVSVKTNSDCGSCTSCAEVTTHWKGLAATHMCVIDTNDPICVGENTVYRICVTNRGSAEDTNVSLILKFSKELQPVSSSGPTKGTITGNTVVFDALPKLGSKESVEFSVTLKGVAPGDARGEAILSSDTLTVPVADTENTHVY
What is the function of this protein?
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin.  It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan.  It is present but the disulfide bonds are reduced in reticulate bodies (RBs) (By similarity).
What are the official names of this protein?
Large cysteine-rich periplasmic protein OmcB, Large-CRP, 60 kDa CRP, 60 kDa outer membrane protein, Cysteine-rich outer membrane protein.
What are the subcellular locations of this protein?
Periplasm.
Protein: AUSC_ASPCI
Sequence: MEMRGIENKSDIALAEFRLTGINGPDKDSSGSTYPDAAAVEAKYEAERQIQLRAHETVSDIEITVDDGWTDLAQDPWAGCPDPAGETPHLLTQRSHLLSQHRHRVLIVGAGFGGLLFAVRLLQTGQFKASDIVIADTAAGFGGTWYWNRYPGLMCDTESYIYMPLLEETGYMPRDKYASGSEIRQHAERIARYWGLETRAMFRTSVRDLAWDEDKKIWNVAGRLLGDVMDTEQFRMAADIVLLASGSFASPRVPNYPDIAKYKGKLFHTARWDYQFTGGSLENPKLTGLADKRVGIIGTGASAVQIIPHLARYSRSLIVFQRTPAAVDARDNRPTDPVWWKEEMASQGAGWQQRRQKNFNAFTCNETPLPGNNCVGDGWTRMPSFSLLIGGPQNLAPDYIDQMRAVDLVRQAQIRERAHALVQDPVAADLLTPWYPGWCKRPCFHDDYLSALNEENVRLVDLRHGGLSHFTPSGVVANGEEYELDLIVLSTGYTVPVTRASPGSRGNISITGRNGMTMEAKWANGLATLHGVMTRDLPNLFFAGTSQAGACVNLTYSVDQNATHVAYILGKAFERRPPNCDKVVLQPTHEGEEQWAGEVLARAAAFRGIAGCTPGYLNGYGKSLDSLSPEQQVNMARLAAWGEGIASYVNRLEEWREKGELEGVEMTFLN
What is the function of this protein?
FAD-binding monooxygenase; part of the gene cluster that mediates the biosynthesis of calidodehydroaustin, a fungal meroterpenoid (PubMed:28233494, PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:28233494).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:28233494).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:28233494).  The cytochrome P450 monooxygenase ausR then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:28233494).  The hydroxylation catalyzed by ausR permits the O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:28233494).  The short chain dehydrogenase ausT catalyzes the reduction of the double bond present between carbon atoms 1 and 2 to convert 7-dehydrodehydroaustin into 1,2-dihydro-7-hydroxydehydroaustin (PubMed:28233494).  AusQ catalyzes not only an acetylation reaction but also the addition of the PKS ausV diketide product to 1,2-dihydro-7-hydroxydehydroaustin, forming precalidodehydroaustin (PubMed:28233494).  Finally, the iron/alpha-ketoglutarate-dependent dioxygenase converts precalidodehydroaustin into calidodehydroaustin (PubMed:28233494).
What are the official names of this protein?
FAD-binding monooxygenase ausC, Austinoid biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.