PharMolix/UniProtQA huggingface dataset:
Protein: QUEG_ROSLO
Sequence: MSGLKEKLVARALEEGFIACRICRPDAVPDVAARLKAFVDAGYHGQMTWMADRMHWRGDPTQLWPQARSVIMLAESYGPEHDPMAVLQQPERGAISVYAQGRDYHDVVKKRLKRLARWLMAEAADADPQVKVFVDTAPVPEKALGQAAGLGWQGKHTNLLSREWGNWAFLGAVFTTLDIAPDAAEVDHCGSCRACLDVCPTDAFPAPYKLDARRCISYLTIEHKGPVPTDLRPLLGNRIYGCDDCLAVCPWNKFATAARDMRLSARPELTAPRLADLAALDDAAFRALFSGSAVKRIGRNRFVRNVLYAIGNSGEASLRQIASELTDDPDDAVADAARWAVAQLGG
What is the function of this protein?
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
What are the official names of this protein?
Epoxyqueuosine reductase, Queuosine biosynthesis protein QueG.
What is the protein family that this protein belongs to?
Belongs to the QueG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH4_DESVH
Sequence: MEDVQNSPAQVAMPIDRVGVKNLQLPLVVSDRAQGRQHTVATVDIGVDLPAHFKGTHMSRFVEALENWTEELDYASMKRLLEDVKTRLEARKAYVLFRFPYFIRKKAPATGSPGLVCYQCRLTGELEEGRPSFLLEVEVPVMTVCPCSKAISDEGAHSQRAVVRIAVRMTRFSWLEEFIDLAEVSGSSPVYTLLKREDEKYVTEDAFAHPTFVEDVVRAAAQRLERHPQISWFRVEVESFESIHCHNAFASIERTITPETQPGS
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: TNI3K_HUMAN
Sequence: MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
What is the function of this protein?
May play a role in cardiac physiology.
What are the official names of this protein?
Serine/threonine-protein kinase TNNI3K, Cardiac ankyrin repeat kinase, Cardiac troponin I-interacting kinase, TNNI3-interacting kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Expressed at lower levels in the cytoplasm.
Protein: UVRB_BORAP
Sequence: MIDFFLKSEYLPAGDQPKAIKEIENSILLGNKYQTLKGVTGSGKTFTIANIIKNLNRPALVVSHNKTLAAQLYREFKDFFPNNAVEYFVSYYDYYQPESYVPSKDLFIEKEATINSEIEIKRIRTVTSLAKRRDVIVVATVSSIYALGSPDFFKKSAREFFVGQRISIKEISDIFVELYYERTLINLERDKFSIKGDIIEIWPSSEHGEFAYRICLDFDEIVKIYRISSFSKKNLGATNSFTLFAKSYFVIPYQNVLEAIPKISYDLDLQCQYFKDNGKLVEAERLKQRVEYDLEMLRETGFCSGIENYSKYLSGSTMGRPYCLFDFFPKDYLLFVDESHVTLPQFRGMYNGDYSRKLNLVNFGFRLPAALENRPLKYDEFDALINQVVFVSATPGFEENEKSSVTVDQIIRPTGLVDPEIITRHSDGQMEDLYIEIQKRVALKERVLITTLTKKMSEDLTEYLVTLGVKAKYLHSELDTLERVEVISLLRKSEIDVIVGINLLREGLDIPEVSLVAILDADKVGFLRSATSLIQTIGRAARNSNGLVIMYYDKISVAMREAIEETNRRRQIQIDYNKKNNITPKTIVKKIQNILEKELNNKNKNISYDFEKMVSGEKLSKKKLIDKLKFELEEAVNDERFEDAIVLRDKIKELGSKISVARNK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLVE_ASPFN
Sequence: MPGKQFPLKEYIAALAKFLDTIEYQDDNFSHEQRVESLRYVYQHTAKHFDQPIEKAAVTVSPKRLQAVMRTSTLVTVYCWVKCPLDVMVGVSIYFAYIIMLDDSSDTPTTEMKTFCEDLIKGRPQKHLFWQRMNAHLTNFLRYYDGFCAITIFRSTLDFFQGCWIEQNNFGGFPGSSYFPHFLRRLNGLGGISSATLFPRSEFDEGTVFEEIVTAIAQIEPQLTLCNDLISFYKEYDSPRDQINLVSNLAHCNGVSWEIAFEELTRDTILYCEQLVTVFKGKDPKVEATVRAFVHGYVTWHLCDPRFRMQEVYEQAGQSEADLKFRHFYEQATSIGVIDFKLWASPSRLSSDKRKHEQAFGDDPQNGKTRVLESIGQANASEAVALAPLA
What is the function of this protein?
Terpene cyclase; part of the gene cluster that mediates the biosynthesis of flavunoidine, an alkaloidal terpenoid with a tetracyclic cage-like core connected to dimethylcadaverine via a C-N bond and acylated with 5,5-dimethyl-L-pipecolate (PubMed:31885262).  The tetracyclic core is synthesized by the terpene cyclase flvE and the cytochrome P450 monooxygenase flvD (PubMed:31885262).  The terpene cyclase flvE catalyzes the cyclization of farnesyl pyrophosphate (FPP) to form (1R,4R,5S)-(+)-acoradiene and the cytochrome P450 monooxygenase flvD is then responsible for oxidative conversion of (1R,4R,5S)-(+)-acoradiene into the tetracyclic cage present in the final product flavunoidine (PubMed:31885262).  In parallel, the N-methyltransferase flvH dimethylates L-lysine to give N,N-dimethyl-L-Lysin which is decarboxylated by flvG to afford dimethylcadaverine (PubMed:31885262).  The terpene cyclase-like protein flvF is the enzyme that attaches the dimethylcadaverine precusor at the C-7 of the tetracyclic cage to yield pre-flavunoidine (PubMed:31885262).  The cytochrome monooxygenase flvC hydroxylates the C-10 position of pre-flavunoidine whereas the NRPS flvI acylates the terpenoid core at the hydroxylated C-10 with dimethylpipecolate to yield final flavunoidine (PubMed:31885262).  The bifunctional enzyme flvA and the dehydrogenase flvB are responsible for the synthesis of the dimethylpipecolate precursor (PubMed:31885262).  The PLP-dependent lyase domain of flvA might use L-O-acetyl-homoserine and alpha-keto-isovalerate to form an intermediary ketone that can cyclize intramolecularly to yield an imine (PubMed:31885262).  The imine can be reduced by flvB to yield the 6-carboxylated pipecolate (PubMed:31885262).  The C-terminal alpha-KG-dependent oxygenase domain of flvA is then proposed to catalyze the decarboxylation to yield dimethylpipecolate (PubMed:31885262).
What are the official names of this protein?
Terpene cyclase flvE, Flavunoidine biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the trichodiene synthase family.
Protein: TIG_SALPB
Sequence: MQVSVETTQGLGRRVTITIAADSIETAVKSELVNVAKKVRIDGFRKGKVPMNIVAQRYGASVRQDVLGDLMSRNFVDAIIKEKINPAGAPNYVPGEYKVGEDFTYSVEFEVYPEVELTGLESIEVEKPVVEVTDADVDVMLDTLRKQQATWKEKDGAADAEDRVTIDFTGSVDGEEFEGGKATDFVLAMGQGRMIPGFEDGVKGHKAGEEFTIDVTFPEEYHAENLKGKAAKFVINLKKVEERELPELTEEFIKRFGVEDGSVAGLRAEVRKNMERELKGAVRNRVKSQAIEGLVKANDIDVPAALIDSEIDVLRRQAAQRFGGNEKQALELPRELFEEQAKRRVVVGLLLGEVIRTNELKADEERVKGLIEEMASAYEDPKEVIEFYSKNKELMDNMRNVALEEQAVEAVLAKAKVSEKATSFNELMNQQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RS10_METRJ
Sequence: MNGQNIRIRLKAFDHRILDASTKEIVSTAKRTGATIRGPIPLPTHIAKFTVNRSPHIDKKSREQFEMRTHKRVLDIVDPTPQTVDALMKLDLAAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: KAD_CLOBB
Sequence: MKIVLLGPPGAGKGTQAKSISNRYSIPHISTGDIFRKNISENTPLGMEARSYMDKGLLVPDEVTINMVKDRLQEEDCLSGYLLDGFPRTVAQAEALNEFLENRNEQLDTALLIDVPSEFILDRMTGRRVCTSCGGSFHIKFNPPTIDGKCNLCGSDIVQRKDDTVETVKERIDVYDKQTQPLIEFYKSKNLLSMVDGTKAIDQVFEDICKLLGEQ
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_MYCUA
Sequence: MTESPTTTPGSTSGAPSGVPSGVNDAESDAPRHRYTAELAAGVERTWQQNWARLGTFNVPNPVGSLAPSDGSPVPEDKLFVQDMFPYPSGEGLHVGHPLGYIATDVFARYHRMKGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANVVNFRRQLGRLGLGHDSRRSFSTTDVEFYKWTQWIFLQIYNAWFDAAANKARPISELVAEFDSGARSLVDGRDWSTLSAGERADVIDDHRLVYRADSMVNWCPGLGTVLANEEVTSDGRSDRGNFPVFRKRLRQWMMRITAYSDRLLDDLDVLDWPDQVKTMQRNWIGRSTGASALFTATRSNGETVGLEVFTTRPDTLFGATYLVLAPEHDLVDDLVGAGWPAGVDPLWTGGGATPAEAVAAYRRAIAVKSDLERQESKEKTGVFLGSHAINPATGQPVPIFIADYVLAGYGTGAIMAVPGHDQRDWDFARALGLPVVEVIAGGDISQAAYTGDGVLVNSGFLDGMSVGEAKQAITARLESDGYGQARIEFKLRDWLFARQRYWGEPFPIVYDADGRPHALDESALPVELPDVPDYSPVLFDPDDANSEPSPPLGKATEWLHVELDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNADRFCAKENETYWMGPRPAEHGPDDPGGVDLYVGGAEHAVLHLLYARFWHKVLYDLGHVSSREPYRKLINQGYIQAFAYTDARGSYVPAEEVIERDGGFVYPGADGEIEVFQEFGKIGKSLKNSISPDEICDDYGADTLRVYEMSMGPIEASRPWATKDVIGAHRFLQRVWRLVIDENTGEILVADTPAELDTDTLRALHRAIAGVAEDYAALRNNTAVAKLIEYTNFLTKRHRDAVPRAVIEPLVLMVAPLAPHLAEELWQRLGHTTSLAHGPFPAADPAYLIDDTVEYPVQVNGKVRGRVVVAADADDDAVKAAALADQKVQAFLAGASPRKVIVVAGRLVNLVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETL_NEOYE
Sequence: MSVFLGYIIFLAAFFGLATGLFLGLKAIKLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PYRG_SHIBS
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLSEWEQVIFEEANPVSEVTIGMVGKYIELPDAYKSVIEALKHGGLKNRVSVNIKLIDSQDVETRGVEILKGLDAILVPGGFGYRGVEGMITTARFARENNIPYLGICLGMQVALIDYARHVANMENANSTEFVPDCKYPVVALITEWRDENGNVEVRSEKSDLGGTMRLGAQQCQLVDDSLVRQLYNAPTIVERHRHRYEVNNMLLKQIEDAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAASEFQKRQAK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: ATPE_STAA3
Sequence: MNTLNLDIVTPNGSVYNRDNVELVVMQTTAGEIGVMSGHIPTVAALKTGFVKVKFHDGTEYIAVSDGFVEVRKDKVSIIVQTAETAREIDVERAKLAKARAESHLENDDDNTDIHRAERALERANNRLRVAELK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NCPP_KLEAE
Sequence: EALGPVMSQHTGIDQIGRKEGAIGVFTAGKLTRSSVYHQAVVLALSPFHNAIYR
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: NUP62_RAT
Sequence: MSGFNFGGTGAPAGGFTFGTAKTATTTPATGFSFSASGTGTGGFNFGTPSQPAATTPSTSLFSLATQTSTTQTPGFNFGTTPASGGTGFSLGISTPKLSLSSTAATPATANTGSFGLGSSTLTNAISGASTSSQGTAPTGFVFGSSTTSAPSTGTTGFSFTSGSASQPGASGFNIGSVGSLAQPTALSGSPFTPATLATTTAGATQPAAATPTAATTSAGSTLFASIAAAPASSSTTVLSLSAPATTAATPTAGTLGFSLKAPGAAPGASTTSTTTTTTTTTTTASTSSSTTTTGFALSLKPLVPAGPSSVAATALPASSTAVGTTTGPAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEESVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNMAGGPADTSDPLQQICKILNAHMDSLQWVDQSSALLQRRVEEASRVCESRRKEQERSLRIAFD
What is the function of this protein?
Essential component of the nuclear pore complex (PubMed:2190987, PubMed:8707840).  The N-terminal is probably involved in nucleocytoplasmic transport (By similarity).  The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (By similarity).  Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (By similarity).  It might be involved in protein recruitment to the centrosome after nuclear breakdown (By similarity).
What are the official names of this protein?
Nuclear pore glycoprotein p62, 62 kDa nucleoporin, Nucleoporin Nup62.
What is the protein family that this protein belongs to?
Belongs to the nucleoporin NSP1/NUP62 family.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle.
Protein: RARB_NOTVI
Sequence: RHSAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQRCFEVGMSKESVRNDRNKKKKEPIKQECIESLEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNS
What is the function of this protein?
Receptor for retinoic acid.  Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.  The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity).
What are the official names of this protein?
Retinoic acid receptor beta, RAR-beta, Nuclear receptor subfamily 1 group B member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: INP5E_DROME
Sequence: MQHSSAGSEERITSSTSSPRSGHKTASSLFGLLSKRPSKVEPHPVTPESPRLQQRPVSACGQYDVSFAKCNADTSANHVNNNGSTLKSQTLPLEKSHSGLISFHRRAKPSSSKGKNHSHRHSTDAGSQSDGGADVVMRRKSPKHRSPNHNRFSHQFSLCCKAEKKPMTPPVTVRYNSIPDSNSVLRRDNLSLSWSMVDNNSGSLHSSEGSSHRPRPSSECASAPESPVASKTFFAHCSPAAASASVARSESLQNRSPIRPMAVSACRSRLRLKLYPPGQELPPLQAATEPGDIKRATTPQHMSSPNIATQPDGIEHIEEQPGVRFMSHENMTLQRQGSGSNLARQTLMAAHALNLIPADNARERSYLDGRLGSTSLLGPSELSRVLPQKEITVFVGTWNMNGHSPPKQLNDFVLPANVEHVPDIVVMGTQESTPDRFEWEVTIQETLGPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFRTKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWALFRTLIRAGTDAIPLAAGLFSRDIYLEGMRRRLNNQYSGASAVCVLQ
What is the function of this protein?
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to phosphatidylinositol 4-phosphate (PI-4-P).  By controlling the phosphoinositide composition of the cilia membrane of auditory receptor neurons, regulates the cilia localization of ktub and consequently the transient receptor potential channels iav and nompC.
What are the official names of this protein?
Inositol polyphosphate 5-phosphatase E, Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, Phosphatidylinositol polyphosphate 5-phosphatase type IV.
What is the protein family that this protein belongs to?
Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type IV family.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Localized to the transition zone, which marks the boundary between the plasma membrane and the ciliary membrane.
Protein: EUTH_LISM4
Sequence: MSINEIIIYLMVIFMILGAIDKIIGNKFGLGAQFEEGIMAMGSLTLAMVGIITLAPVLAKILSPIVVPIYTALGADPAMFATTLLANDMGGFALAQELALTPDAGLFAGAILGSMMGPTIVFTIPVALGIIKKEDHKYLATGVLSGIITIPIGCLIGGLVAGFSPIMIFKNLVPIILVAALIMLGLWFKPEGMIKGFTIFGKGVVIVATIGLVAGAIQQLTGLTIIPGIAPIGEGIEIVGGIALVLAGAFCLVFVITKVFNKPLMKMGKLLGMNEVAAAGMVATLANSIPMFQMLKDMDERGKIINVAFAVSAAFVLGDHLGFTAGVAQDMIFPMIVGKLVGGVTAVAVGIYMANRMMKKNKAKEQTAVKDNG
What is the function of this protein?
Probably involved in the diffusion of protonated ethanolamine (EA) into the cell at low pH.  At low pH most EA is protonated, and this permease becomes necessary (By similarity).  Contributes to bacterial survival and replication in acidic macrophage vacuoles, but not to bacterial uptake by macrophages (PubMed:29531136).
What are the official names of this protein?
Probable ethanolamine permease EutH, Ethanolamine utilization protein EutH.
What is the protein family that this protein belongs to?
Belongs to the EutH family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RSMF_ECO57
Sequence: MAQHTVYFPDAFLTQMREAMPSTLSFDDFLAACQRPLRRSIRVNTLKTSVADFLRLTAPYGWTLTPIPWCEEGFWIERDDEDALPLGSTAEHLSGLFYIQEASSMLPVAALFADGNAPQRVMDVAAAPGSKTTQIAARMNNEGAILANEFSASRVKVLHANISRCGISNVALTHFDGRVFGAALPEMFDAILLDAPCSGEGVVRKDPDALKNWSPESNQEIAATQRELIDSAFHALRSGGTLVYSTCTLNREENESVCLWLKETYPDAVEFLPLGDLFPGANKALTEEGFLHVFPQIYDCEGFFVARLRKTQAIPALPTPKYKVGNFPFSPVKDREAAQIRQAAASVGLNWDGNLRLWQRDKEVWLFPVGIEALIGKVRFSRLGIKLAETHNKGYRWQHEAVIALASPDNENAFELTPQEAEEWYRGRDVYPQAAPVADDVLVTFQHQPIGLAKRIGSRLKNSYPRELVRDGKLFTSNA
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_CERSK
Sequence: MGIQAAEISAILKEQIKNFGQQAEVAEVGRVLSVGDGIARVHGLDNVQAGEMVEFPGGIRGMALNLEVDNVGVVIFGDDRSIKEGDTVKRTKSIVDVPAGDALLGRVVDGLGNPIDGKGPIAATERRVADVKAPGIIPRKGVHEPMATGLKSVDAMIPIGRGQRELIIGDRQTGKTAIALDTILNQKSYNEAAGDDESKKLYCIYVAIGQKRSTVAQLVKKLEETGAIDYTLVVAATASDPAPMQFLAPYAATAMAEYFRDNGRHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERSAKLNKDHGAGSLTALPIIETQGGDVSAFIPTNVISITDGQIFLETELFYQGIRPAVNTGLSVSRVGSSAQTDAMKSVAGPVKLELAQYREMAAFAQFGSDLDAATQQLLNRGARLTELMKQPQYAPLTNAEIVCVIFAGTKGYLDKVPVKDVGRWEQGLLKHLRTNAKDLLADITNNDRKVKGELEDKIRAALDTYAKDFA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YO22A_YEAST
Sequence: MESQQLHQNPHCPHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQEETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQDQHSEVPQAKTKVRNNVLPPHPHTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYSDILTVLCKSVSKMQTNNQELKDWIALANLEYNGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYHRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLRPATERI
What is the function of this protein?
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.  The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules.  CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
What are the official names of this protein?
Transposon Ty2-OR2 Gag polyprotein, TY2A, TYA, Transposon Ty2 protein A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_EXISA
Sequence: MRLRHKPWAKEYMEAQEHVFIQHPEQLKGNWSTEFGNDHPLFIEVGSGKGQFILGMAKQHPDVNFIAIELFESVAVSIVQKLVETPMPNVRVLTVDAKRLVDYFEAGEVDRVYLNFSDPWPKTRHAKRRLTYKTFLATYEAILPKAGEIHFKTDNRGLFEYSLQSMSQYGMFFTEISLDLHVNEPEDNIRTEYEERFSALGQPIYRMEAVFRPKN
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: TRPA_XANAC
Sequence: MRRIDSCFAELRANGRKALIPFITAGDPSLEATVPVMHALVRAGADVIELGVPFSDPMADGPTIQRSSERALARGAGLAYVLEAVHEFRREDATTPVVLMGYLNPIEIHGTRRFAEAAVAAGVDGVLLVDLPPEEAGETRTIFTEVGLALIALASPTTSEQRLDMLCSTAQGYLYYVSFAGVTGASNLLDTHAASDRLRQLRRRAGAPVVAGFGIKDAASAAAMAVDADGVVVGSALVAALAEVNDVRSARERAEAFLAPLRQALDQG
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: NRDR_SHIF8
Sequence: MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREPFNEEKLRSGMLRALEKRPVSSDYVEMAINHIKSQLRATGEREVPSKMIGNLVMEQLKKLDKVAYIRFASVYRSFEDIKEFGEEIARLED
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.