PharMolix/UniProtQA huggingface dataset:
Protein: PTPJ4_MDBVW
Sequence: MDNKSQRRNNENQKKVEALDFLSFMRRPNCIAEILRQHTQIIEESNNYYYLKMKTKDNKSQGPLRSLLCLPKNVNQKTDSAFCSVDGYNVKNKFLCTRSPNQDSLYQFWSMAYKKNIHIIVMLSPIDNLMRHRYWSLEEDEVFECREFRIETLQVDVQAFYITTTLQLKHENGAVRKIVHFNYTGWPVDNISHHPKEFISFILTVNSARDEVDKLSARNSHTLGPIMVHCSDGFNNSCVYCLLDICISEFGATSNVSVPNTFSKIRQQNRHAISQPENYVYCYQALYVWISSISNSLHH
What are the official names of this protein?
Probable tyrosine phosphatase protein J4, PTP-J4.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
Protein: AKR1_YARLI
Sequence: MSTDAELQTISGLSVASKSAPSTQTEGVTASGKVESTTNAEEATSDVEEEENPLVVAARDGNTAEVKRLCESGSYSVLDTAEDGVTALHWAAVNNRISTCQYLVEQGAVVDAKGGQLNGTPLHWACRRGLVYIVHYLIQNGADPLRSDVQGYNALHLATHSSNVMLLVYLLHQGLPVDCQDPNGRTALHWAAYQGDALSVDVLLRWGSDVKITDTQGFLPLHWGIVNGSRNSLARLIEEGSDMYAKSSDGKTPHVMAAEMNTTAQLEGALDDCGRFPDGSQKTKYFDARTTNLLCFFTPFILILLGLVLCTFCGPIFGIILTVATLFGSIKLLKTLVLPSLYNGHAALLKSPFQAGIFTGSAFWVTVKYLTSVLPATFASHPILNFFFASIFGLAMYCFFRCMSMDPGYIPKLSGITEQKEVIETLIERGEFDTRHFCFVTYVRKPLRSKFCRQSKRVVARFDHFCPWVWNAIGVRNHRMFVLYVLFLQIGIPLWLALNSAYFGELLEIKRWDPLEFYLVIWISLQLIWITFLSFVQIFQICRSLTTSEAVNLQKYGYMGADDYSSVPLDHSAATASAKSVMNAHGHAAKSPCFSSVLKLLGVDQFVATAGEAIKHRDNRSWKEKNPTDSGAGTNCFDFWFPNGKFDLLAVFEAGKGGGAIGGHAVDYYKLWDFPDVSPNQQQTNNRSTREDGEALLAESQV
What is the function of this protein?
Palmitoyltransferase specific for casein kinase 1.
What are the official names of this protein?
Palmitoyltransferase AKR1, Ankyrin repeat-containing protein AKR1.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
What are the subcellular locations of this protein?
Early endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: PEPB_CROS8
Sequence: MTEAMKITLSHEPADARWGEKALYSFTQDGIALHLTGKDDLGLIQRAGRKIDGQGLKHVELAGDGWDVEKSWAFWMGYRGPKGKRTVTWAPLDDAQQKELNNRLKVIDWVRDVINAPAEEMGPEHLAQRAVDLLADVGGERVSYRITKGEDLREQNYMGLHTVGRGSERPPVLLALDFNPTGDANAPVFACLVGKGITFDSGGYSIKQTAFMDSMKSDMGGAALVTGSLAFAITRGLNKRVKLILCCADNMISGNAFRLGDIIRYRNGKTVEVMNTDAEGRLVLADGLIDASAQKPALIIDAATLTGAAKTALGNDYHALFSFDDALANRLLQSAQAENEAFWRLPLAEFHRNQLPSNFAELNNTAGGAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAAVEQWAAGATGIGVRTLANLLTAE
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMD_VIBCH
Sequence: MARFFQPKKHSTLDTKHQPVTIERLDHQGSGLAFLHKKPLFVDGALPGEEVLIQLTENKSKYARGQLIKVLKPSAERVAPFCAHYAQCGGCDLQHLDRAGQIHHKQQALSQLMVKFAGQSLALSAPVCSDDQGYRRRARLSLMWDKKTQQLQLGFRRKQSKAIVNVTHCPVLEPSLNALLPDLNALLSEWSQPERLGHVELVKGDNTRVLVLRHLGALIEQDQQRLTDFASQNQLTLYLMLEAGELQHVQGEAPYCEETGSRLSFLPSHFIQVNRAVNQHMVVQALNWLEVSPQERVLDLFCGLGNFTLPLAKQAQAVVGVEGVDEMVQHATHNAKLNQINNVAFYQANLEQDMTSASWAQQKFAKVLLDPARAGAEGIVDQLSALGAKRVVYVSCNPATLARDSQSLLSQGFRLEKLGMLDMFPHTSHLESMALFVKKG
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: EFNMT_XENLA
Sequence: MDLLPKSSKEFAAPEYWEQFFRRRGERAFEWYGGYLELCGLLHKYIKPRDKVFVVGCGNSELSEQLYDAGCQNLTNIDVSEVVIRQMNERNSNRRPNMTFQVMDATQTTFDDSCFQAVLDKGTLDAIMTDTDKGTLETADKLMSEIGRVLTCGGRFLCVSLAQAHVLEKLVRHFSQGGWMVRVHQVMQGSTSETGSQFPMPVFVFVMTKVRQISGFPTVLEMMPDEEGGKPVRWGSPEEFMEAVKERQRYALIRNRLNQNQSSQEVSLDLCDGDSRKSRYTFYIVDSPAVRLSHSNHFAIFIIPHGRETEWLFGSEQGRKQLAGSVGFNRLIIVALHRDQQYTDMKAIQSELSAKVLELAPPGLPDNQQIPFLSAGEDIGSRTIQHRGKSEFSGEYVVEDVRGDGNSSYRRLIFLSNQNVVQSEARLLPISTHIGQKKRKDKKKQQKPVKDLEQPTITRIDKSYLCCEHHKAMISGLALLPNPGLLPECQASVLVIGLGGGSLSLFIHDYFPGSRVEVVEIDPSVLDVASNWFNFCQDERMKVHLADGLVHINSLADNGEACYDVIMFDVDSKDPSVGMSCPPPAFVEKMFLQNVHNILNANGVFILNLVCRDTDLRLKVLNVLHEVFPLIYAQKIDEEVNEILFCRPNSERKFSSLELKESAKNLEKKLRKPGVQWDSTYSLAEMLKSVQIV
What is the function of this protein?
Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (eef1a1 and eef1a2) at two different positions, and is therefore involved in the regulation of mRNA translation.  Via its C-terminus, methylates the N-terminus of eef1a1 and eef1a2.  Via its N-terminus dimethylates lysine residues of eef1a1 and eef1a2.
What are the official names of this protein?
eEF1A lysine and N-terminal methyltransferase, Methyltransferase-like protein 13.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: RS8_DEHM1
Sequence: MISDPIADMLTRIRNGVMAKHEVVIMPASRMKQYLAKVMKQEGFIAGYEVIGAKPKRQLKIVLRYDEGGASFVSGLERISKPGLRVYVQRGEIPRVYGGLGIAIVSTSKGVMTGSQAWRQGLGGELLCKVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PURQ_STAA8
Sequence: MKFAVLVFPGSNCDRDMFNAAIKSGVEAEYVDYRETSLSGFDGVLIPGGFSFGDYLRSGAMASVAPIISEVKRLAAEGKPVLGVCNGFQILTEIGLLPGALLHNDSHLFISRNEELEIVNNQTAFTNLYEQGEKVIYPVAHGEGHYYCTDEIYQQLKANNQIILKYVNNPNGSYDDIAGIVNEKGNVCGMMPHPERALETLLGTDSGVKLFEAMVKSWREQHV
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUN2_RHIHE
Sequence: MVLCCFALLITAVLVASKGAEEKPTCDPDHENKKVLWTCWTDDYNTTCFERSFYYNRQTDRCEEFLYEGCGGNDNNFPSIEDCLSNCKTNMTDYEIKFFQRLNKTLSCTSTYEKGSISRYILNETSQECQRADVKNGDIHFPSFRKCVYDCKPNSTSNPYCNSIKENGTKPRAPWNCYRQDGYKALFCYKPKNSK
What is the function of this protein?
Anticoagulant protein that inhibits the serine proteases trypsin and elastase, but not thrombin (PubMed:25708749).  The anticoagulant effect of this recombinant protein on blood clotting is found only in the activated partial thromboplastin time (APTT) assays, but not in the prothrombin time (PT) assays (PubMed:25708749).
What are the official names of this protein?
Anticoagulant protein rhipilin-2.
What are the subcellular locations of this protein?
Secreted.
Protein: ADCY5_HUMAN
Sequence: MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
What is the function of this protein?
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542).  Mediates signaling downstream of ADRB1 (PubMed:24700542).  Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).
What are the official names of this protein?
Adenylate cyclase type 5, ATP pyrophosphate-lyase 5, Adenylate cyclase type V, Adenylyl cyclase 5, AC5.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, cilium.
Protein: YQGA_ECOLI
Sequence: MVIGPFINASAVLLGGVLGALLSQRLPERIRVSMTSIFGLASLGIGILLVVKCANLPAMVLATLLGALIGEICLLEKGVNTAVAKAQNLFRHSRKKPAHESFIQNYVAIIVLFCASGTGIFGAMNEGMTGDPSILIAKSFLDFFTAMIFACSLGIAVSVISIPLLIIQLTLAWAAALILPLTTPSMMADFSAVGGLLLLATGLRICGIKMFPVVNMLPALLLAMPLSAAWTAWFA
What are the official names of this protein?
Uncharacterized protein YqgA.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYY_HAEDU
Sequence: MAQSIEAILAELKRGVENIYSEEDLIAKLKENRPLRIKLGADPTAPDIHLGHTVVINKLRQFQQLGHEVIFLIGDFTGMVGDPSGKNTTRPPLTREDVLRNAETYKQQLFKILDPNKTRVVFNSAWLNELGTEGMIRLTSNYTVARMLERDDFKKRFTNNQPIAIHEFIYPLLQGYDSVALQADVELGGTDQTFNLLVGRELQKSAEQKPQVAITLPLLVGLDGEKKMSKSLGNYIGVTEAPNEMFGKVMSISDELMWDWYNLLSFRPLAEITQLKADVDAGKNPRDVKILLAKEIITRFHSEAEADLAEQHFINRFQKGAIPDEMPEFCFNGEIGLATLLKEAGLVASTSEAIRSAQQGGVKIDGQKIDDVRANAQLGTFVYQVGKRKFARVTVK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_BART1
Sequence: MRLTVVGANGRMGRELITAIRQRKDVELCAVLVRKNSPFVGKDASVLIGSDSLGIRITDDPENAFSSTEGIVDFSHPQASLLYADYAAQKKLVHIIGTTGFSKTEEEKIAEFAKYTTIVKSGNMSLGINLLANLVKKAAKALEADDFDIEIYEMHHANKVDAPSGTALLLGQAAAEGRNVMLQDVRINERNGYTGKREKGSIGFSCSRGGTVIGEHSVIFAGSHERIVLSHTAQERSIFANGALKAASWAKNHANGLYSMLDVLGLNDQF
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_PELTS
Sequence: MTAELEAQARTEKTRSFTHSLREKGMIPAVVYGKNVGSLSIAVDAGELQKILEGAGSNALIRMKIKENGKIRKHNVLVKEVQRDPVRRELIHADFHQVSLKDRVHATVPVHLTGSAAGTVEGGVLTPLLRRVEMECLASEIPEAITVDVSGLRIGDTITVADLPLPPGVRALEDPEAPVVTVTAGERPAAEPAAAPGAAPAAGPEEAEE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: RL10_BRASO
Sequence: MERAAKKEAVEQLHEVFKTTGVAVVAHYSGLTVAQMQNLRKQMKQAGASVKVSKNRLAKIALEGTDVVGIGPLLKGPTVIATSNDPVAAPKVAIEFAKANEKFVILGGSMGSTVLNVDSVKALASLPSLDELRGKLVGLIQAPATKLAQLANAPAAKVARVIQAHASKGEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: MEND_KINRD
Sequence: MNPSTALATVLVDTLVRLGLRHLVLSPGSRSAPLAYAAARAADEGRLTLHVRVDERSAGFLALGLARAGELVAVVTTSGTAVANLHPAVLEAHHAGVPLVVLSADRPHELRGSGASQTADAQARMFLPSVRYSADVPAPVDPDRQAPAWRSLLSRAVAFARGLRGDGPGPVHLNVGFADPLTPSPGDVPPGPGLTQVHGPGAPAPVALERGPRTLVLAGDAPDPATGAAARELAESAGWPLLAEPSSGARGGERAVGPYRLLLDAVDAEGPLGAVERVVLFGHPTLSRPVTRLLARDDVELVVVSAAGTWSDAGFRAARVVPAAQVQGPPGAGEQEFAARWDRAGKLAADAVDAALDAEAGLSGPWAAREVVAACAADGSTLVVAASNAIRDVDLTARPLGVRTVSNRGLAGIDGTTATAEGVALATGPTRLLLGDLAFLHDANALLPVPGEVRPDLTVVVVNDDGGGIFETLEHASAVDRATFERVVATPHGVDVAALCAAFGVAHSRPATRAEALAALTARPRGLRVVELVTARDRVRPRLERIAAAVRAAVA
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: MIRO2_HUMAN
Sequence: MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDEELREEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEAVLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEELNAFQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPVELQSLFSVFPAAPWGPELPRTVRTEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPGYAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVACLMFDGSDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLATMAAFPHLVHAELHPSSFWLRGLLGVVGAAVAAVLSFSLYRVLVKSQ
What is the function of this protein?
Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657).  Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657).
What are the official names of this protein?
Mitochondrial Rho GTPase 2, MIRO-2, hMiro-2, Ras homolog gene family member T2.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial Rho GTPase family.
Protein: NEIL1_HUMAN
Sequence: MPEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASARGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRFYTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRNLADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEALQQHRPSPELTLSQKIRTKLQNPDLLELCHSVPKEVVQLGGKGYGSESGEEDFAAFRAWLRCYGMPGMSSLQDRHGRTIWFQGDPGPLAPKGRKSRKKKSKATQLSPEDRVEDALPPSKAPSRTRRAKRDLPKRTATQRPEGTSLQQDPEAPTVPKKGRRKGRQAASGHCRPRKVKADIPSLEPEGTSAS
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil.  Has marginal activity towards 8-oxoguanine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.  Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.  Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
What are the official names of this protein?
Endonuclease 8-like 1, DNA glycosylase/AP lyase Neil1, DNA-(apurinic or apyrimidinic site) lyase Neil1, Endonuclease VIII-like 1, FPG1, Nei homolog 1, NEH1, Nei-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Chromosome. Note=During mitosis, associates with centrosomes and condensed chromatin.
Protein: GLPK_STRGC
Sequence: MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAGWVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKNTGLPIYNAIVWQSRQTAPLAEQLKSQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEGAQERAEKGELLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAMLPEVRSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYALNSHNNDEVYVVPAFTGLGAPYWDQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDIIDTMQVDAKTAIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGLSVGYWKDLDELRTLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEIDD
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: ARGB_ACIC5
Sequence: MKYVVKLGGAALENPEIFMACARAVADLVKDGHQVALVHGGGVQLTRTLKQLGKQSEFIAGLRVTDAETRDAALMVLSGRVNKSLVAALGSLGQAAMGLSGGDGLIFRARKKRTVPDLGFVGEIVASDPRWLEAIWKMNAVPVISSIALGFDGEYYNVNADEMAAACAAACRADALVFLTDVPGVRGADGTIMRWLTVDQIPVLSQTEVISGGMLPKLGACREALLNGVKRVRILPAEAAHVLPDLCSARVTDGTEVMAS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLA_SALTI
Sequence: MKKMAIACALLSSVVASSVWADAASSLKSRLDKVSSFHATFTQKVTDGSGAAVQEGQGDLWVKRPNLFNWHMTQPDESILVSDGKTLWFYNPFVEQATATWLKDATGNTPFMLIARNQASDWQQYNIKQDGDNFVLTPKASNGNLKQFTINVGRDGTIHQFSAVEQDDQRSAYQLKSQQNGAVEPSKFTFTPPQGVTIDDQRK
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ARGR_MYCMM
Sequence: MNGAKQAPEISVNRAGRQARIVAILSTESVSSQSELAALLAVQGIEATQATLSRDLEELGAVKLRGADGGVGVYVVPEDGSPVRGVTGGTGRLARLLGELLVSSDASANLAVLRTPPGGAHYLASAIDRAALPYVVGTIAGDDTVFVAAREPMTGAELAIALEKLK
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FER2_RICMO
Sequence: MSGKIKVTFIINDGEEKTVEAPIGLSILEIAHSNDLDLEGACEGSLACATCHVILEEEFYNKLKKPTEAEEDMLDLAFGLTDTSRLGCQIILTEELDGIKVRLPSATRNIKL
What is the function of this protein?
Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
2Fe-2S ferredoxin, Adrenodoxin-like protein.
What is the protein family that this protein belongs to?
Belongs to the adrenodoxin/putidaredoxin family.
Protein: TRMB_RUEPO
Sequence: MSKTTPDRPRRNFYGRIKGKTLKPNQRTYLDEDLTPLAPGPVSWQDNPTRQPLDLNALFGGRETWLEIGFGGGEHLVHQAASNPGIGIIGAEPYINGVAMLLGKIRAAGGDNVRVHPGDVRDLFDVLPAQSISRAFLLYPDPWPKKRHHRRRFVTPEHLEPLARVLKPGAIFRVATDIPDYVRQTLEEVPRAGFEWLAERPADWRQPWGDWISTRYEQKALREGRVPHYLTFRRLEG
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: OXYR_SHEEP
Sequence: MEGAFAANWSAEAVNGSAAPPGTEGNRTAGPPQRNEALARVEVAVLSLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLAVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTEAAAAEASAGAEGAAADCAGRAALARVSNVKLISKAKIRTVKMTFIVVLAFIVCWTPFFFKQMWSVWDADAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFQDLVQRFLCCSFRRLKGSQLGETSVTKKIHSYTFVLSRHSSSQRSCSQPSTV
What is the function of this protein?
Receptor for oxytocin.  The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Oxytocin receptor, OT-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUDC_HAEIG
Sequence: MKILQQDDFGYWLLTQGSNLYLVNNELPFGIAKDIDLEGLQAMQIGEWKNHPLWLVAEQESDEREYVSLSHLLSLPEDEFHILSRGVEINHFLKTHKFCGKCGHKTQQTQDELAVQCTHCGYQTYPVICPSIIVAVRRGHEILLANHKRHYSPNGGIYTTLAGFVEVGETFEQAVQREVFEETGISIKNLRYFGSQPWAFPNSQMVGFLADYESGEITLQESEIYDAQWFSYDQPLPELPPTGTIARKLIHATLELCKAEHKCD
What is the function of this protein?
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.  The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing.  Has preference for mRNAs with a 5'-end purine.  Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
What are the official names of this protein?
NAD-capped RNA hydrolase NudC, DeNADding enzyme NudC, NADH pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudC subfamily.
Protein: KAD_STRTD
Sequence: MNLLIMGLPGAGKGTQAAKIVEEFGVAHISTGDMFRAAIANQTEMGRLAKSFIDKGELVPDEVTNGIVKERLAESDIAEKGFLLDGYPRTIEQAHALDETLKALDIKLDGVINIEVNPESLVERLSGRFICRSCGSTYHKVFNPTKVEGTCDVCGGHEFFQREDDKPETVKRRLDVNIAQGEPIIAHYRELGLVSDIQGNQDIDDVFADVKKAIAAIK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.