PharMolix/UniProtQA huggingface dataset:
Protein: TRUA_METAR
Sequence: MKTALKIAYVGTNFYGSQAQPGLPTVESELRKALEEAGAIKLGTKIAMAGRTDAGVHALGQVVAFEQADPKLTAPRIINSKLPKDLWAYARAEVPDDFDPRRHATSREYRYILYAPDVIERRLKECSSRFLGTHDFTNFSSVEAGKYPVRTVTRLDIAKRGDFYIIDIEADSFLWNMVRKIVTALRLVGENKRPDGWIEKMFDPEYREGIPPAAPGGLYLSRVNYDGIAFEEDEYARQRAYQRMLNSFEWHHTIAEIYKEFKDAMK
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: RF2_RHOE4
Sequence: MHPDVIADLNALDTTLRTCESVVDVEELRRRIDELEHQAADPGLWNDQEHAQQVTSQLSHAQAELRRIVALRERLDEMPILYELAEDEGPDAVADADAERASLRDDIAAMEVKTMLSGEYDERDALINIRSGAGGIDAADWAEMLMRMYIRWAEKHDYGVEVYDTSYAEEAGLKSATFAIKGPYTYGTLSVEMGTHRLVRISPFDNQGRRQTSFAEVEVLPVVETTDHIEINENDIRVDVYRSSGPGGQSVNTTDSAVRLTHIPTGIVVTCQNEKSQLQNKVSAMRVLQAKLLAVKRQEERAEMDALKGDSGSSWGNQMRSYVLHPYQMVKDLRTEYEVNNPSAVLDGDIDGFLEAGIRWRMSENQSA
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_STAHJ
Sequence: MEAKAVARTIRIAPRKVRLVLDLIRGKNAGEAIAILKLTNKASSPVIEKVLMSALANAEHNYDMNTDELVVKEAYANEGPTLKRFRPRAQGRASAINKRTSHITIVVSDGKEEAKEA
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL18_ECOLU
Sequence: MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ZNTB_SALNS
Sequence: MEAIKGSDVNVPDAVFAWLLDGRGGVKPLEDNDVIDSQHPCWLHLNYTHPDSARWLASTPLLPNNVRDALAGESSRPRVSRMGEGTLITLRCINGSTDERPDQLVAMRLYMDERFIVSTRQRKVLALDDVVSDLQEGTGPVDCGSWLVDVCDALTDHASEFIEELHDKIIDLEDNLLDQQIPPRGFLALLRKQLIVMRRYMAPQRDVYARLASERLPWMSDDHRRRMQDIADRLGRGLDEIDACIARTGIMADEIAQVMQESLARRTYTMSLMAMVFLPSTFLTGLFGVNLGGIPGGGWRFGFSLFCILLVVLIGGVTLWLHRSKWL
What is the function of this protein?
Zinc transporter.  Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.
What are the official names of this protein?
Zinc transport protein ZntB.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: 7LESS_DROME
Sequence: MTMFWQQNVDHQSDEQDKQAKGAAPTKRLNISFNVKIAVNVNTKMTTTHINQQAPGTSSSSSNSQNASPSKIVVRQQSSSFDLRQQLARLGRQLASGQDGHGGISTILIINLLLLILLSICCDVCRSHNYTVHQSPEPVSKDQMRLLRPKLDSDVVEKVAIWHKHAAAAPPSIVEGIAISSRPQSTMAHHPDDRDRDRDPSEEQHGVDERMVLERVTRDCVQRCIVEEDLFLDEFGIQCEKADNGEKCYKTRCTKGCAQWYRALKELESCQEACLSLQFYPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADGQSTPLTIRWAMHFPEHYLASRPFNIQYQFVDHHGEELDLEQEDQDASGETGSSAWFNLADYDCDEYYVCEILEALIPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEHLMGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAGRGSYIFSQLQAGTNYTLALSMINKQGEGPVAKGFVQTHSARNEKPAKDLTESVLLVGRRAVMWQSLEPAGENSMIYQSQEELADIAWSKREQQLWLLNVHGELRSLKFESGQMVSPAQQLKLDLGNISSGRWVPRRLSFDWLHHRLYFAMESPERNQSSFQIISTDLLGESAQKVGESFDLPVEQLEVDALNGWIFWRNEESLWRQDLHGRMIHRLLRIRQPGWFLVQPQHFIIHLMLPQEGKFLEISYDGGFKHPLPLPPPSNGAGNGPASSHWQSFALLGRSLLLPDSGQLILVEQQGQAASPSASWPLKNLPDCWAVILLVPESQPLTSAGGKPHSLKALLGAQAAKISWKEPERNPYQSADAARSWSYELEVLDVASQSAFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWPLGPHRLRWASRQGSVIHTNELGEGLEVQQEQLERLPGPMTMVNESVGYYVTGDGLLHCINLVHSQWGCPISEPLQHVGSVTYDWRGGRVYWTDLARNCVVRMDPWSGSRELLPVFEANFLALDPRQGHLYYATSSQLSRHGSTPDEAVTYYRVNGLEGSIASFVLDTQQDQLFWLVKGSGALRLYRAPLTAGGDSLQMIQQIKGVFQAVPDSLQLLRPLGALLWLERSGRRARLVRLAAPLDVMELPTPDQASPASALQLLDPQPLPPRDEGVIPMTVLPDSVRLDDGHWDDFHVRWQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRTAWRSGDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAPEQGQEAPMQALEYHISCWVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAPEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVPGSAPAKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLNLPMITASEDCPLPIPGVRYQLNLTLARGPGSEEHDHGVEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPEDENLTLREVPLKDKQLYANEGVSRL
What is the function of this protein?
Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor.  The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell.
What are the official names of this protein?
Protein sevenless.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: GLMM_HELPS
Sequence: MKIFGTDGVRGKAGVKLTPMFVMRLGIAAGLYFKKHSKTNKILIGKDTRKSGYMVENALVSALTSIGYNVIQIGPMPTPAIAFLTEDMRCDAGIMISASHNPFEDNGIKFFNSYGYKLKEEEEKAIEEIFHDEELLHSSYKVGESVGSAKRIDDVIGRYIVHLKHSFPKHLNLQSLRIVLDTANGAAYKVAPVVFSELGADVLVINDEPNGCNINEQCGALHPNQLSQEVKKYRADLGFAFDGDADRLVVVDNLGNIVHGDKLLGVLGVYQKSKNALSSQAIVATSMSNLALKEYLKSQDLELKHCAIGDKFVSECMQLNKANFGGEQSGHIIFSDYAKTGDGLVCALQVSALVLESKQVSSVALNPFELYPQSLINLNIQKKPPLESLKGYSALLKELDKLEIRHLIRYSGTENKLRILLEAKDEKLLESKMQELKEFFEGHLC
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: DNLI_METM7
Sequence: MLFIDFCKILDKIEKTTKRLEKTDYFVELIDFIKTNGKPENLKQVSQITIGRVFAEFENKEIGIGPNLLLEAVKTTGISEKDLKSKIKETGDIGIAVENLSSNIKQVSLFSQALTLEEVYSTLKKLSEIEGNSSQKKKTRIISNLLILATPVESRYISRLILEDMRIGMNIPTILASFSNYFNINKETVEKIYAVTNDIGLLGEKLISGSNIENDSELQLKVFRPIKPMLAQLTPSIEAAIIETKMPQFETKYDGARVQVHKSDGNVKIYSRRLENITNSVPELVEEIKKIDIDNIILEGECVAMDLSSGKPRPFQDILRRFRRKYDIDKMAEKIALRIYFFDVLYYEKGLIDTPLKDRREILEKLFGTNNWDTELSKIEKEIFSNKMLFSSFKLNSDDPILAKEFFNWSLSIGHEGIMIKNPDAPYTPGSRVKTMYKVKPTLENLDVVVTRAKIGMGKRKDWYGSYEISVKDYEDNLHVIGNVGTGLTEDDLEKLTKIVNEIKIEDLGEEVILEPKIVLEVTYEEIQTSEKYEMGYALRFPRVVQIREDKSINDINTLDDVKKIYEIERNRK
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: Y232_SYNY3
Sequence: MGWEFFSLETLQELARQYGYGAVFFGIALENAGIPIPGETITLLGGFLAGSGDLSYGGVLIAAIAGAVLGDSCGYWVGRWGGWPLLTRAAQLFNIPQEKLDQARHKFSQNGAAAVFFGRFVTLLRIFAGPMAGIVRMPYGKFLLYNIGGASVWAAITVSLAYFLGRVVTIEQIIAWTTQFSWFALAAVVGMVGIYFVFHFLQKRFDQTIESTIGDRPQ
What are the official names of this protein?
Uncharacterized membrane protein slr0232.
What is the protein family that this protein belongs to?
Belongs to the DedA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROA_PSE14
Sequence: MRPQATLTVLPVERPLVGRVSPPGSKSITNRALLLAGLAKGTSRLTGALKSDDTRVMSEALRLMGVQVDEPDDSTFVVTSSGHWQAPQQALFLGNAGTATRFLTAALANFEGDFVVDGDEYMRKRPIGPLVDALQRMGVEVSAPSGCPPVAIKGKGGLEAGRIEIDGNLSSQYVSALLMAGACGKGPVEVALTGSEIGARGYVDLTLAAMQAFGAEVQAIGETAWKVSATGYRATDFHIEPDASAATYLWAAQALTEGDIDLGVASDAFTQPDALASQIIASFPNMPAVIDGSQMQDAIPTLAVLAAFNRQPVRFVGIANLRVKECDRISALSHGLCAIAPGLAVEEGDDLLVHANPALAGTTVDALIDTHSDHRIAMCFALAGLKIAGIRILDPDCVGKTYPGYWDALASLGVRVQR
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_PARDP
Sequence: MLRTGVIAKKLGMTRLFLEDGRQVPVTVLHVDNVQVIAQRTAEQDGYVALQLGAGEAKAKRTTAALRGHFAKANVAPKRKIAEFRVSPENLVEVGEEIVADHYFEGQYVDIAGTSIGKGFAGAMKRHNFGGLRASHGVSISHRSHGSTGQCQDPGKVFKGKKMAGHLGAVRVTTQNLQVVKTDAERGLIMVKGSVPGSKGGWVTIKDAVKKPLAESTVFPAATRSKAVQAEAAAPAEAAAPEGDN
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: YBN7_YEAST
Sequence: MFKGSVSLYILCFALGLRNTFLIYNVCNNIKNNCMDNTSGPIGDTIFLIYGIIIIIGPRRCFFFYLKRVVLLQGTHEWCTQGLFPWLKKLEITNVHCHLRRFIICQLHLI
What are the official names of this protein?
Uncharacterized protein YBR027C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LFTY1_MOUSE
Sequence: MPFLWLCWALWALSLVSLREALTGEQILGSLLQQLQLDQPPVLDKADVEGMVIPSHVRTQYVALLQHSHASRSRGKRFSQNLREVAGRFLVSETSTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPRTALRRQKRLSPHSARARVTIEWLRFRDDGSNRTALIDSRLVSIHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPGTWSSHKLVRFAAQGTPDGKGQGEPQLELHTLDLKDYGAQGNCDPEAPVTEGTRCCRQEMYLDLQGMKWAENWILEPPGFLTYECVGSCLQLPESLTSRWPFLGPRQCVASEMTSLPMIVSVKEGGRTRPQVVSLPNMRVQTCSCASDGALIPRRLQP
What is the function of this protein?
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
What are the official names of this protein?
Left-right determination factor 1, Protein lefty-1, Lefty protein, Stimulated by retinoic acid gene 3 protein, Transforming growth factor beta-4, TGF-beta-4.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: UREE_MARMS
Sequence: MLDIYERLGTHCHDPVYTTVTLTHEQRDRGRLKLVGENNEEVRVFLERGKPLLVGEFLKSECGKIVQVAGAVEDVAHASCEDWEAFSKACYHLGNRHTKIQIGERWLRIKPDHVLEDMLHMLGLIVTHEEAVFVPESGAYSHGHSHH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLM8_PLABA
Sequence: MNKFFVFPLLLILNSIVLVKSLTENLRVSRYSKPGVSTIILKGGYINRQFIGEISIGNPPQSFKVLFDTGSTNLWIPSKNCYAKACYNKKKYDYNISKNYRISSSKNPVNIFFGTGKVQIAYATDDIHLGSIKVRNQEFGIANYMSDDPFSDMQFDGLFGLGISEDIKRKGLIYDNIPRNSSRKNVFSIYYPKSVDDNGAITFGGYDKKYIEPNSNIDWFVVSSRKYWTIKMTGIKINGLFLEVCSGNIEGYCDAVIDTGTSSIAGPQNDLILLTKLLNPVKSCQNKTLLKNFSFVFSDENGVEKEYELTSNDYIVNSFKVDPILKNPCNFAFMPINISSPNGYLYILGQVFLQKYYAIFEKDNMRIGLAKSI
What is the function of this protein?
During the development in the mosquito vector, plays an essential role in sporozoite egress from the oocyst and sporozoite gliding motility, which is required for the invasion of salivary glands and subsequent transmission to the host.
What are the official names of this protein?
Plasmepsin VIII, PbPMVIII, Plasmepsin 8.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
Protein: MPAA3_AMBEL
Sequence: GKVYLVGGPELGGWKLQSDPRAYALWSARQQFKTTDVLWFNFTTGEDSVAEVWREEAYHACDIKDPIRLEPGGPDRFTLLTPGSHFICTKDQKFVACVPGR
What are the official names of this protein?
Pollen allergen Amb a 3, Allergen Amb a III, Allergen Ra3.
Protein: RL17_PROM3
Sequence: MRHQCRVPKLGRPTDQRKAMLRGLTTQLIREGRVTTTKARAKALRDEAERMITLAKNGSLASRRRAIGYIYDKQLVHALFDKAQDRYGDRQGGYTRIIRTVPRRGDNAEMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: HBEAG_WHV4
Sequence: MYLFHLCLVFACVPCPTFQASKLCLGWLWGMDIDPYKEFGSSYQLLNFLPLDFFPDLNALVDTATALYEEELTGREHCSPHHTAIRQALVCWDELTKLIAWMSSNITSEQVRTIIVNHVNDTWGLKVRQSLWFHLSCLTFGQHTVQEFLVSFGVWIRTPAPYRPPNAPILSTLPEHTVIRRRGGARASRSPRRRTPSPRRRRSQSPRRRRSQSPSANC
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.  This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein, p25.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: Y019_ONYPE
Sequence: MSKDDSIKKTVTIGLSAAIFFVLSCFASIPVGFNVSIETSVAFLAFIAVAFGPAVGFYVGLIGNTIKDFILFGNVSWNWVLCSALIGFIYGLPHKIIDLKYQVFTKKKIVYFWLYQVAFNFIIWGFFAPQSDLLIYGQPPKLVYLQSFLIVISNILAYSVVGIKLMSMYSCHYNKQATLIKINNS
What are the official names of this protein?
UPF0397 protein PAM_019.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: C521A_DICDI
Sequence: MILLTLLYLIIFYIIIDFIKKNYKTKNQLPSPLGIALPIIGHLHLLRTDPYKTLAKASKKTEHGILKCWNGEHLMVVVDNPSIIKQMYVNTNNFTDRPQTKVFEIISRNYKNSGFANGEKWKHLRGLYAPSFTKIKSRPHENIILKYVNFEIKSLKNHAITNSIYNPFLIENINSFGTKVITEIIFGREFSENEVYSLIGPMNKLFGILDTPFPSESISFLKPFYRRSYKECDKQCEELFKLVEKVYDDHLLNLDKDNPKDVMDVMIVETDFKEKDHVICICCDLLMGTKDTFNTIVLWFFVLMINYQDVQLKGYQEIIKVLECTGRDHVTIEDIDKLPYIDGIIKEISRIHPAGPLSVPRTAINDIMINGYFIPKGCHVFQNTYGAVYNYMKESDEPCKMKPERWIENEKLRKDGKLDPTNDLALISLPFSSGIRNCPGVGFAEYELFLLFSNIILNFHLSSPNNLKLNESGHFGLTMKPFPFLVDLKLR
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the trisnorsesquiterpene discodiene which has a function during later stages of multicellular development, during the transition from fingers to Mexican hats (PubMed:31063135).  The terpene synthase tps8 converts its substrate farnesyl diphosphate (FDP) into the bicyclic sesquiterpene alcohol discoidol (PubMed:31063135).  The cytochrome P450 monooxygenase cyp521A1 then catalyzes the oxidative degradation of discoidol to form the trisnorsesquiterpene discodiene (PubMed:31063135).
What are the official names of this protein?
Cytochrome P450 monooxygenase 521A1, Discodiene biosynthesis cluster protein cyp521A1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: UVRB_METTH
Sequence: MMKFKLVSDYRPLGDQPKAIRSLVNGIKAGMREQTLLGVTGSGKTFTVANVIAEVQKPTLVISHNKTLAAQLYEEFREFFPENAVEYFVSYYDFYQPEAYIPQTDTYIDKEASINDEIDRMRHSATQSLLSRDDVIVVSSVSCIYGIGAPTDYGEFTLHLEVGSGPGREEVLEGLINMQYERNDVEFDRGQFRVRGDTVEINPIHGTPPIRIEFFGDEIDSISTVHRVTGRRIQKLDRVTIFPAKHFVIPEDRLQRAIESIEAELEERLTELRSQNKLLEAQRLEQRTRFDMEMLREMGYCQGIENYSMHLSGRKWGEKPNTLLDYFPEDFLTVIDESHVTVPQIRGMYNGDRARKDTLVEYGFRLPSARENRPLRFDEFQESVNQVIYVSATPGRYELSRSQNIVEQIIRPTGLVDPEVRIRPVKGQVDDLLSEIRRRVERGERVLVTTLTKRMAEDLTDYYSRVGVKVRYLHSEIDTLERVEIIDDLRRGEFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSETSLIQTIGRAARNVNGEVLIYAGRFTDSVMAAVETTNRRRKLQMEYNRRHGIKPRSTRRTLREEEGPLRNLKVDEIPDHELELIIKDLEAEMRDAARNLEFERAARIRDRIMSLKSN
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPSR_CANLF
Sequence: MTQRWGPQRLAGGQPQAGLEESTQASIFTYTNSNATRDPFEGPNYHIAPRWVYHLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAIADLAETIIASTISVVNQIYGYFVLGHPLCVVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIAGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMTTCCIIPLSVIILCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAYCLCWGPYTFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDSSELSSASRTEASSVSSVSPA
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.
What are the official names of this protein?
Long-wave-sensitive opsin 1, Red cone photoreceptor pigment, Red-sensitive opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: UL49_ALHV1
Sequence: MPVMGCSVCSAFAELSRWAHGYPGGQTDAVAIEGDLWQLNLQILDVLEIDHASFVNFVFLGKGLTCIPWGTRGEFFTSWIQGLLERCSCPSVDIHKQLFYYGIYMCYFLTVYLLLYPSPVIIKYARSFFRGEQLWHLLCKFEWVIEKFMEYVFKINFNHPVIKINEGDLESYMFLRKKLKRQYLTPQLAVPPLFTRLPPSLQFIDEGHTHLDTHGEALASALKSCCEDVPCGSPFDSMVKNLALRCALSHQFSVIPVSDQSPNIVTQIREKILSISVLACVVRVPILSATVWSLVETKRPTFFVYCGECKHCLNFGKGKFLKVNFNPTHAFYCRDQKEKQCNVCATTGRIYCSFCGSADIHTASLTQMLDGVPIIRAVMANNAAFMLDTAQRSVDFILPCLGTHAKCEGSVLRRLSLLQLLYLTLNASELMCARCQS
What are the official names of this protein?
Uncharacterized gene 66 protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL49 family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: DNLJ_MIMIV
Sequence: MDIIKKIKKSKSLWAILPSLNATDIEEALSVSSEYYHNTGTSLISDQEYDILMDRLKELNPSSKIFAQVGAPVKGKKVKLPFWMGSMNKIKADEKAVNKWLNEYSGPYVISDKLDGISCLLTIKNNKTKLYTRGDGTYGQDITHLLGLINIDIGLLEEIDQDIAIRGELIMSKKNFEKYQEIMANARNMVGGIVNSKPESVNKDHAADVDLIFYEVIKPNDKLSRQLKILKEWGLKVVYYNIYKTFDVNILESVLSERKKKSGYEIDGIIVTDNNKHVRNISGNPSYSFAFKGDTPTIDTVVKRVIWTPSKDGVLVPRIKFKKVRLSNVDLEYTTGFNAKYIVDNKIGSGAIINVVRSGDVIPYITHVVKPAKKPDLPNIEYVWDKNGVNIILADINDNETVIIKRLTKFMRNIGAENISEGITTRLVEAGFDTIPKIINMTEEDFLTIDGFQERLAEKIYNNLQNSLDNLDILTLMDASNIFGRGFGTKKFKKILDVYPNIVNQYTKETDNIWRKKLLDIEGFDTITVNKFLGEMPNFQKFYKVINKTITIKPYISEVNSEGIFQNQTVVFTGFRNADWQKFIENEGGKVSGSVSKNTSLLVYNDGEESSAKYQKAKQLGIKTMTKSSFSKKFEK
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase, NAD-dependent DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family.
Protein: AQP10_HUMAN
Sequence: MVFTQAPAEIMGHLRIRSLLARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFLAGSLAVTIAIYVGGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQLLSAFCASGATYVLYHDALQNYTGGNLTVTGPKETASIFATYPAPYLSLNNGFLDQVLGTGMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLSMGANCGIPLNPARDLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGTATYQLLVALHHPEGPEPAQDLVSAQHKASELETPASAQMLECKL
What is the function of this protein?
Water channel that mediates water transport across cell membranes, but that is not permeable to glycerol.
What are the official names of this protein?
Aquaporin-10, AQP-10, Aquaglyceroporin-10, Small intestine aquaporin.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Lipid droplet. Note=Detected around lipid droplets.
Protein: B2MG_CALGO
Sequence: MARFVVVALLVLLSLSGLEAVQRAPKIQVYSRHPAENGKPNFLNCYVSGFHPSDIEVDLLKNGKKIEKVEHSDLSFSKDWTFYLLYYTEFTPNEKDEYACRVSHVTFSTPKTVKWGRNI
What is the function of this protein?
Component of the class I major histocompatibility complex (MHC).  Involved in the presentation of peptide antigens to the immune system (By similarity).
What are the official names of this protein?
Beta-2-microglobulin.
What is the protein family that this protein belongs to?
Belongs to the beta-2-microglobulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: IBP5_BOVIN
Sequence: MVLTAVLLLLAACAGSAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQAKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQKSEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE
What is the function of this protein?
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.  They alter the interaction of IGFs with their cell surface receptors.
What are the official names of this protein?
Insulin-like growth factor-binding protein 5, IBP-5, IGF-binding protein 5, IGFBP-5.
What are the subcellular locations of this protein?
Secreted.