PharMolix/UniProtQA huggingface dataset:
Protein: EFG_ECO8A
Sequence: MARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMAKQYEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVNQIKTRLGANPVPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELANEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVEANVGKPQVAYRETIRQKVTDVEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDEAPSNVAQAVIEARGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXC_ECOSE
Sequence: MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: GCH1_COXBU
Sequence: MSNTIADHVKAILIALGEDPNREGLRDTPKRYEKALEHLTKGYHEKLPSVVKKAVFQSGMDEMVILKDIELYSLCEHHLLPFIGRCHVAYLPSGKIIGISKLARIVDMFAKRLQVQENLTKQIAEAILTATEAKGVGVIIEAKHLCMMMRGVEKQNSEMTTSVMLGTFRKDDRTRSEFLSLIRK
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: SUCC_CROS8
Sequence: MNLHEYQAKQLFARSGLPTPVGYACSTPREAEEAASKIGSGPWVVKCQVHAGGRGKAGGVKVVKSKEEIRAFAEHWLGKRLVTYQTDANGQPVNQILVEAATDIAKELYLGAVVDRGSRRVVFMASTEGGVEIEKVAEETPHLIHKVAIDPLTGPMPYQGRELAFKLGLEGKLVQQFTKVFMGLANIFLERDLALIEINPLVITSQGDLICLDGKLGADGNALFRQPDLREMRDQSQEDPREAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGEPANFLDVGGGATKERVTEAFKIILSDDKVKAVLVNIFGGIVRCDLIADGIIGAVAEVGVNVPVVVRLEGNNAELGAKKLADSGLNIIAAKSLTDAAQQVVAAVEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: REM17_ARATH
Sequence: MADQSLLHSPINPHFFQPILTESRTHLNIPVAFFSKHVEGRNNQNKTVTLRSDASDKTWLVKMDGLKLTDGWEDFAFAHDLRTGDIVVFRLEGEMVFHVTALGPSCCEIQYHTSSHNINDDDRNDQINIASRNSSRVKKNPRKKVESSLDHSRFVAKVSAWCLSNDRLYIPLSFARLNGLNKINSKKIYLQNEEGRSWKLVLRHDKSGMQTFVQSGWRRFCSENGIRQGQYTFKLVRKSAPPVIRLCRAKAKPKQRSVAEYSSDHSCFEGSVTPSSLRNDLLYLPRSFVNSNRLDKRCSEIVLKNEQGVKWPLVLKRFKSVTYLPKGWTSFCQVNRIKAGDSFKFKLVGTWKKPVLSLCPTQSNNHKTPLECSEGNKSEESEEDCLEVKKKKYWSRCRASVENMDDDQTNIGNSSRKKRVSKNPREKVESSSDHSSFVGSVNPSSLYKDQLYLPRNFVSSNFLDKRCSEIVLKNERGEKRTLVLKHFKKDLTFLKKGWTSFCQVNRIKAGDSFKFKLVGTWNKPVLSLCPTETNYHKTPLACSEGNKSEESEEEGTEDKNTSQDCLEVKKRKYWSTCRASAENIDDDQTNIGNSSKEKRVKKNPVKKAESSSDHSSFVANVTASSLNYDRLYLPLSFVSSNGLDKMNGKEIVLLNEEGLSWKFNLKYNQAGKHTYVRPGWSRFCDANGMSQGQQFTFKLVQKHGPPVMYLSLSEHRPKSESSSHRSYFVGSVTASSIKKDKLYLWKSFVSSNGLDKGCKKIILKNKWGREWKLVLKHYKSNCFTIIKRGWTSFCQGNGLKAGDSFKFKLVGTGEKPVLSLCPAESSHEKIPLECPEGIDDVNSLSSNPSSGDDSSRSEESEEENMEDKNISQDCLETKKRKYCSSSSYSQNRFVTLTLTRSAFQTYKLVSFFNNYASRLS
What are the official names of this protein?
B3 domain-containing protein REM17, Protein REPRODUCTIVE MERISTEM 17.
What are the subcellular locations of this protein?
Nucleus.
Protein: MAO1_COLP3
Sequence: MPQSQRPLYIPYAGPSLLETPLLNKGSAFSKEERGSFNLTGLLPPRFESIDEQAERAFRQYSCFQTNINKHIYLRAIHDNNETLFFKLVQNNLAEMMPIIYTPTVGDACEQFSDIYRSSRGLFISYEDRFNIDDMLRNATKNKVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAHTLPVMLDVGTNNQKLLDDPMYMGARHKRIDQDSYDEFLELFISAVKRRWPNVLLQFEDFAQPNAMPLLQRYKDRICCFNDDIQGTASVTVGTLLAACRSKGSKLSELNVAFVGAGSAGCGIAEQIISQMMNEGLGAEQARSQVFMVDRFGLLTQGMGELRDFQQKLVQSNEAIAEWDIAGEFASLVEVMHGAKPDILIGVSGQAGLFTEKVITAMKSHCEMPIIFPLSNPSRQVEATPSQVINWTQGQVIIATGSPFDPIEYQGKTFPIAQCNNSYIFPGVGLAVVAANISRITDGMLQVASETLAAASPLANGESDELLPPLTSIAQLSRDIAFAIAKVAYKQGLALELTDDELLAKIEHNFWKPEYRQYRRTSL
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: RL35_ANADF
Sequence: MPKLKTKSGAKKRFIPKKSGKVKFRRAGVRHLATFGKTKKQKRHLRGTDHLAPMDAKKIKECFPYAR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: GA4_GIBF5
Sequence: MSIFNMITSYAGSQLLPFYIAIFVFTLVPWAIRFSWLELRKGSVVPLANPPDSLFGTGKTRRSFVKLSREILAKARSLFPNEPFRLITDWDFADEIRNDPRLSFSKAAMQDNHAGIPGFETVALVGREDQLIQKVARKQLTKHLYIIARISSRIYLGDQLCRNEAWLKITKTYTTNFYTASTNLRMFPRSIRPLAHWFLPECRKLRQERKDAIGIITPLIERRRELRRAAIAAGQPLPVFHDAIDWSEQEAEAAGTGASFDPVIFQLTLSLLAIHTTYDLLQQTMIDLGRHPEYIEPLRQEVVQLLREEGWKKTTLFKMKLLDSAIKESQRMKPGSIVTMRRYVTEDITLSSGLTLKKGTRLNVDNRRLDDPKIYDNPEVYNPYRFYDMRSEAGKDHGAQLVSTGSNHMGFGHGQHSCPGRFFAANEIKVALCHILVKYDWKLCPDTETKPDTRGMIAKSSPVTDILIKRRESVELDLEAI
What is the function of this protein?
Gibberellin 20-oxidase; part of the gene cluster that mediates the biosynthesis of gibberellins (GAs), diterpenoids that may provide a selective advantage during infection of the preferred host plant, rice (PubMed:23825955, PubMed:9917370, PubMed:10347043, PubMed:12750377, PubMed:15925394).  Gibberellins (GAs) are diterpenoids and are synthesized via the mevalonate pathway (PubMed:12750377).  Biosynthesis of the major metabolite GA3 (gibberellic acid) from geranylgeranyl diphosphate (GGPP) requires 13 steps (PubMed:12750377).  The GGPP produced by the geranylgeranyl diphosphate synthase GGS2 is converted to ent-kaurene via ent-copalyldiphosphate in a two-step cyclization reaction performed by the bifunctional ent-copalyl diphosphate synthase/ent-kaurene synthase enzyme (CPS/KS) (PubMed:9745028, PubMed:10803977, PubMed:12750377).  Ent-Kaurene is metabolized to GAs by a series of oxidation reactions catalyzed by cytochrome P450 monooxygenases (PubMed:9917370, PubMed:12750377).  Cytochrome P450 monooxygenase P450-4 is an ent-kaurene oxidase that catalyzes the three oxidation steps between ent-kaurene and ent-kaurenoic acid (PubMed:11472927).  The highly multifunctional cytochrome P450 monooxygenase P450-1 then catalyzes four steps involving oxidation at two carbon atoms, in the main pathway from ent-kaurenoic acid to GA14 via GA12-aldehyde as well as producing kaurenolides and fujenoic acids as by-products (PubMed:11320210).  The cytochrome P450 monooxygenase P450-2 then converts GA14 to GA4 by removal of C-20 (PubMed:11943776).  GA4 is further converted to GA7 by the GA4 desaturase DES via 1,2-desaturation before cytochrome P450 monooxygenase P450-3, a 13-hydroxylase, hydroxylates GA7 to GA3, the final product of the GA-biosynthetic pathway (PubMed:12750377).
What are the official names of this protein?
Cytochrome P450 monooygenase 2, P450-2, Gibberellin 20-oxidase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AGR4_CYCAE
Sequence: MSALPSQFKLPDLLSTCPLKDGTNPAYKKAAAESRAWIGSYNMFADRKRAFFIQGQNELLCSHVYCYAGYEQLRTTCDFVNLLFVVDEVSDEQSGEDARATGQVFVNAMKYADWHDGSKLAKLTKDFRVRFLRLAGPKNVARFVALCESYTACVGKEAELRESGQVLGVKEFIPLRRQNSAVLLCFSLVEYILGIDLDDEVYRDENFLNAYWAACDHVCWANDVYSYDMEQSKGLSNNNIVTVLMEENHTSLQDTSDYIGEKCAEFVQIYLTSKKRLSPSLGPDAALFLESIGSWMVGNLAWSFETSRYFGSRHLEVKETGIVILRPRELPEDGSSSDSDEE
What is the function of this protein?
Terpene cyclase that catalyzes the cyclization of farnesyl diphosphate (FPP) to various sesquiterpenes, including beta-copaene, alpha-cubebene, cadina-1(6),4-diene, gamma-muurolene, delta-cadinene, epizonarene, epicubenol and cubenol (PubMed:32233445).  Agr4 is also able to use the monoterpene precursor geranyl diphosphate (GPP) as substrates to synthesize the monoterpene beta-myrcene (PubMed:32233445).  Delta-cadinene is the major product of Agr4 (PubMed:32233445).
What are the official names of this protein?
Bifunctional terpene synthase Agr4, Terpene cyclase Agr4.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: KV113_HUMAN
Sequence: MDMRVPAQLLGLLLLWLPGARCAIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 1-13.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: IDI2_RICTY
Sequence: MLEEQNSDIERKQDHIEINLKQNVNSTLKSGLASIKFIHNALPEINYDNIDTTTTFLGKYMKAPILISSMTGGTTRAKDINYRLAQAAQKSGIAMGLGSMRILLTKPDTIKTFTVRHVAPDIPLLANIGAVQLNYGVTPKECQYLIDTIKADALILHLNVLHELTQPEGNRNWENLLPKIKEVINYLSVPVIIKEVGYGLSKQVAKKLIKVGVKVLDIAGSGGTSWSQVEAYRAKNSMQNRIASSFINWGITTLDSLKMLREVSKDITLIASGGLQSGIDGAKAIRMGANIFGLAGQLLKAADIAESLVSEEIQLIIEQLKITMLCTGSCTLKDLAKAEIML
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_RUTMC
Sequence: MQRGKFITIDGVEGSGKSTQIDFICDYLVTKKINVILTREPGGTELGEKIRTLLLSTDIQSIHGDTELLLLFAARNEHIRTKIIPSLEKGDWVLSDRFTDASYAYQGGGRGLSIERITQLEKWVLQDFTPDVTLLLDVSVALGMSRVESRGRKDRIELETNDFFKRVRNSYIERSKQFPKRIKLIDASKTLEQTAQQIKIILQVL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: IF6_METMJ
Sequence: MTGTIDLAGDPNIGVYARVFEDIAIVYPGAPAEFTAALARELDVEIVSTFIQGSSIIGSLVSGNSQGLVVSGLATDEELAVLSEYRDVFLLKGPMNAAGNIILANDCVAAVHPEMQIDVAEEIGSFLEVPVVRLTLGGIKTVGMAGFATNKGILVHPRANDTEIANLERIVDLPIGLGSVNMGSGLVGTGLLANSKGYVAGSVTTGFELGRIEEVFGFLE
What is the function of this protein?
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
What are the official names of this protein?
Translation initiation factor 6, aIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
Protein: FUMOB_CORFA
Sequence: MALSAAASTLARLGYYEKLAGILGIIGLVLLFWQRTRQPFYPDLPLAGETPHRRWFSLRTRFRYYTDCASLFNEAYHTVRFHASTSSSSTLSRLNAHASQYTKHGKGVLLPSVGVHTAVVMPESALDWAMSQPDSALSITHAFADLNQTRYSLGDARYWRDPWQLTLVKAHLAAVTPALVPQLNDELADALAKRLGTDTDSWREMELETTLRRVVAQTLSRLIVGPELCRDEGYLDLAYKVVLGVMTTIFATLPYPDLVRAVTGPLASWHTQRRISRIQRHLEPLYRERLAILRSAKEDQPPDLLMAMMRFAQKKRPEELADPAIIARRVCAANFVAMHQTTIVLTNIILHVLGSDAEFSTIAALRSEAAAHLLSSERITKDAFAQMKVADSVAREATRLNFPLGGRASPRTVMRDGLVSPEGIRLQRGTTVSWLAGCAQLDPEAFPEPRRFDPFRFSRGDGDGEGERDTFVKTSARYLPWGHGKHACPGRFVVDYVVKMALAQLVTKYDLAWPEDYGGKQPPSVWLAELSVPPPRARIMVRRRKV
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumosorinone, a 2-pyridone alkaloid that acts as an inhibitor of protein tyrosine phosphatase 1B which is implicated asa negative regulator of insulin receptor signaling and a potential drug target for the treatment of type II diabetes and other associated metabolic syndromes (PubMed:25857260).  The polyketide-amino acid backbone of fumosorinone is first assembled by the PKS-NRPS hybrid fumoS (PubMed:25857260).  The PKS modules condense one acetyl-CoA starter unit with 7 malonyl-CoA units, programmed C-methylations occurring after the first 3 and the sixth extensions, and cycles of full reduction occurring after the first 2 extensions (Probable).  Because fumoS lacks a designated enoyl reductase (ER) domain, the required activity is provided the enoyl reductase fumoC (Probable).  Upon formation of the polyketide backbone on the thiotemplate, the polyketide is transferred to the NRPS module and linked to tyrosine to produce the acyltetramic acid intermediate called prefumosorinone A (Probable).  The cytochrome P450 monooxygenase fumoA then probably catalyzes an unprecedented oxidative ring expansion of prefumosorinone A to form prefumosorinone B which contains the 2-pyridone core of fumosorinone (Probable).  The cytochrome P450 monooxygenase fumoB might hydroxylate the nitrogen of prefumosorinone B, but not the acyltetramic acid prefumosorinone A, to form fumosorinone (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase fumoB, Fumosorinone biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: K1B11_MOUSE
Sequence: MWFLILFLALSLGGIDAAPPVQSRIVGGFNCEKNSQPWHVAVYRYNKYICGGVLLDRNWVLTAAHCHVSQYNVWLGKTKLFQREPSAQHRMVSKSFPHPDYNMSLLIIHNPEPEDDESNDLMLLRLSEPADITDAVKPIALPTEEPKLGSTCLVSGWGSITPTKFQTPDDLQCVSIKLLPNEVCVKNHNQKVTDVMLCAGEMGGGKDTCKGDSGGPLICDGVLHGITAWGPIPCGKPNTPGVYTKLIKFTNWIKDTMAKNP
What is the function of this protein?
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
What are the official names of this protein?
Kallikrein 1-related peptidase b11, Glandular kallikrein K11, mGK-11, Tissue kallikrein-11.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Kallikrein subfamily.
Protein: HOME1_BOVIN
Sequence: MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDLTQNSEPRPEPTQNALPFTHSSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLERS
What is the function of this protein?
Postsynaptic density scaffolding protein.  Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3.  By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release.  May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity).  Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity).  Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway.  Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
What are the official names of this protein?
Homer protein homolog 1, Homer-1.
What is the protein family that this protein belongs to?
Belongs to the Homer family.
What are the subcellular locations of this protein?
Cytoplasm. Postsynaptic density. Synapse. Cell projection, dendritic spine.
Protein: NDUF7_XENLA
Sequence: MSGLARLQRLQKFGFLMVSASANRPIQRYQCSRTEKPQKRTSANALLNHLIFKIKSTGPITVSEYMREVLTNPVKGYYMHNDMLGEHGDFVTSPEISQIFGELLGVWCISEWVSAGKPKAIQLVELGPGRGTLTDDLLRVFSNFGRLLDSCDISVHLVEVSPKLSDIQAQRLTGKSIEVELDSNSPVYKNGITKTGRPVCWYQDIQDVPNGYSFYIAHEFFDALPIHKLQKIKDGWREMLIDIDPKLPDKLRFVLGSNMSLVAKTFVQDDEPRDHVEVCPSAAVIIQKLAQQINSYGGAALIADYGHMGEKTDTFRGFRAHQLHDVLTDPGTADLTADVDFNFMRRMVGEAASCLGPVTQHVFLKNMGIDIRLKVLLEKSNDVTVQKQLIHGYNVLMNPDQMGQRFKFFSVVPHSRLKNTLKTKMPPVAGFSTLLMT
What is the function of this protein?
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).  Acts by mediating symmetric dimethylation of 'Arg-118' of ndufs2 after it assembles into the complex I, stabilizing the early intermediate complex.
What are the official names of this protein?
Protein arginine methyltransferase NDUFAF7, mitochondrial, NADH dehydrogenase [ubiquinone] complex I, assembly factor 7, Protein midA homolog.
What is the protein family that this protein belongs to?
Belongs to the NDUFAF7 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PYREL_METMA
Sequence: MKNIEDLIQKAVELQNNGLGTGQIADELNVSRETVTWLLTRSKKEVAAPAPKDISVNWSSIGKSATRLHYISLALCDMVIETLEKTNTEVDVVVGVAASGIPLASMMANELGADFALYHSRKGQDMVQPGQKGTISRNFGSVAGKNCVIVDDVITTGSTTMEVIEQLREMDAKPRAVVVLVDKKGADTIANVPIQSLVRIVRVD
What are the official names of this protein?
PyrE-like protein.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: YCGL_ECOL6
Sequence: MPKPGILKSKSMFCVIYRSSKRDQTYLYVEKKDDFSRVPEELMKGFGQPQLAMILPLDGRKKLVNADIEKVKQALTEQGYYLQLPPPPEDLLKQHLSVMGQKTDDTNK
What are the official names of this protein?
Protein YcgL.
Protein: SPICE_HUMAN
Sequence: MSFVRVNRCGPRVGVRKTPKVKKKKTSVKQEWDNTVTDLTVHRATPEDLVRRHEIHKSKNRALVHWELQEKALKRKWRKQKPETLNLEKRRLSIMKEILSDQYQMQDVLEKSDHLIAAAKELFPRRRTGFPNVTVAPDSSQGPIVVNQDPITQSIFNESVIEPQALNDVDGEEEGTVNSQSGESENENELDNSLNSQSNTNTDRFLQQLTEENFELISKLWTDIQQKIATQSQITPPGTPSSALSSGEQRAALNATNAVKRLQTRLQPEESTETLDSSYVVGHVLNSRKQKQLLNKVKRKPNLHALSKPKKNISSGSTTSADLPNRTNSNLDVLKHMIHEVEHEMEEYERWTGREVKGLQSSQGLTGFTLSLVSSLCRLVRYLKESEIQLRKEVETRQQLEQVLGDHRELIDALTAEILRLREENAATQARLQQYMVTTDEQLISLTHAIKNCPVINNRQEIQASESGATGRRVMDSPERPVVNANVSVPLMFREEVAEFPQEELPVKLSQVPDPPDNMNLAKNFPAHIFEPAVLLTPPRQKSNLKFSPLQDVLRRTVQTRPAPRLPPTVEIIEKEQNWEEKTLPIDTDIQNSSEENRLFTQRWRVSHMGEDLENKTQAPFVNLSQPLCNSHSNTQQSRSPTFSEELPVLGDGQQLRTNESLIQRKDIMTRIADLTLQNSAIKAHMNNIIEPRGEQGDGLRELNKQESASDMTSTFPVAQSLTPGSMEERIAELNRQSMEARGKLLQLIEQQKLVGLNLSPPMSPVQLPLRAWTEGAKRTIEVSIPGAEAPESSKCSTVSPVSGINTRRSSGATGNSCSPLNATSGSGRFTPLNPRAKIEKQNEEGWFALSTHVS
What is the function of this protein?
Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.
What are the official names of this protein?
Spindle and centriole-associated protein 1, Coiled-coil domain-containing protein 52, Spindle and centriole-associated protein.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle.
Protein: RECA_ACHLA
Sequence: MSDNKKQQALELALKQIEKQFGKGSIMKLGDGADHSIEAIPSGSIALDIALGIGGYPRGRIIEVYGPESSGKTTLTLHAMASAQKQGGTVAFIDAEHALDPNYAKALGVDLDNLVLSQPDTGEQALDIAEALIKSGSIDMIVIDSVAALVPEAEIAGDMSANHVGLQARMMSQAMRKMSGVISKSNVVAIFINQIREKVGVMFGNPETTPGGRALKFFSSVRLEIRRAEAIKQGSEMIGIKSNVKVVKSKVAPPLKTASIDIMYGTGISRSGEVLDLSVELNLVNKSGAWYNIGEEKLGQGRDNAKQYLEDKPELLNELEKKVRTHFKLTK
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARAG1_BURTA
Sequence: MAAALRFDNIGKVFPGVRALDGISFDVQAGQVHGLMGENGAGKSTLLKILGGEYQPDSGGVLVDGQAMRFPSAAASIAAGVAVIHQELQYVPDLTVAENLLLGRLPSALGWVRKHTAQRFVRERLAAMGVDLDPQAKLRRLSIAQRQMVEICKALMRNARVIALDEPTSSLSHRETEVLFKLVDDLRRDGRALIYISHRMDEIYRLCDACTIFRDGRQVASHASLAQVPRETLVRQMVGREISDIYHYEPRALGDVRLSARALEGDALRSGASFDVRAGEIVGFFGLVGAGRSELMRVIYGADRRTGGALTLDGKPLDIRSTRDAIRHGIVLCPEDRKEEGIVAHASVAENINISCRRHALRAGLFLDLKREAETAERFIKLLKIKTPNRRQKIRFLSGGNQQKAILARWLAEPDLKVVILDEPTRGIDVGAKHEIYGVIYELAKRGCAIVMVSSELPEVLGVSDRIVVMREGRIAGELARGEANEEAVLNLALPQGAIAHAA
What is the function of this protein?
Part of the ABC transporter complex AraFGH involved in arabinose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Arabinose import ATP-binding protein AraG 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TFA_BPP2
Sequence: MQHLKNIKSGNPKTKEQYQLTKNFDVIWLWSEDGKNWYEEVKNFQPDTIKIVYDENNIIVAITRDASTLNPEGFSVVEVPDITSNRRADDSGKWMFKDGAVVKRIYTADEQQQQAESQKAALLSEAENVIQPLERAVRLNMATDEERARLESWERYSVLVSRVDPANPEWPEMPQ
What is the function of this protein?
Acts catalytically in the formation of tail protein dimers.
What are the official names of this protein?
Probable tail fiber assembly protein, GpG.
What is the protein family that this protein belongs to?
Belongs to the tfa family.