PharMolix/UniProtQA huggingface dataset:
Protein: DVL2_MOUSE
Sequence: MAGSSAGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDTPQPEVAPPAHESRTELVPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRDRPRRRDSSEHGAGGHRPGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRMERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESELSSRGGSLRRGGEPGGTGDGGPPPSRGSTGAPPNLRALPGLHPYGAPSGMALPYNPMMVVMMPPPPPPVSTAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM
What is the function of this protein?
Plays a role in the signal transduction pathways mediated by multiple Wnt genes.  Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors.  Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
What are the official names of this protein?
Segment polarity protein dishevelled homolog DVL-2, Dishevelled-2, DSH homolog 2.
What is the protein family that this protein belongs to?
Belongs to the DSH family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Nucleus. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization (PubMed:21189423). Localizes to cytoplasmic puncta. Interaction with FOXK1 and FOXK2 induces nuclear translocation (By similarity).
Protein: RL5_CLOBA
Sequence: MTRLQEKYSKEVIPAMIEKFGYKNVMEIPKLEKIVINMGVGEAKENQKVLESAVSDLSLIAGQKPILTRAKKSVANFKIRENMALGCKVTLRKAKMYEFADKLMSIALPRVRDFRGVSAKAFDGRGNYSLGIKEQLIFPEIEYDKIDKVRGMDIIFVTTANTDEEARELLRFLGMPFAQ
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: HSCB_YERPE
Sequence: MDYFTLFGLPARYLIDGNQLTTRYQELQRQFHPDRFATQPERERLASMQQAATINDAYQTLKHPLKRAEYMLSLQGFDLGNEQHTMRDTAFLMEQLELREELDAIERKPDAETLLAEFSRRVAQMTTTRTQQMVEQLDAQLWVQAADTVRKLRFLDKLQQQVEQLEERLFDDFA
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: GM_EBVA8
Sequence: MKSSKNDTFVYRTWFKTLVVYFVMFVMSAVVPITAMFPNLGYPCYFNALVDYGALNLTNYNLAHHLTPTLYLEPPEMFVYITLVFIADCVAFIYYACGEVALIKARKKVSGLTDLSAWVSAVGSPTVLFLAILKLWSIQVFIQVLSYKHVFLSAFVYFLHFLASVLHACACVTRFSPVWVVKAQDNSIPQDTFLWWVVFYLKPIVTNLYLGCLALETLVFSLSVFLALGNSFYFMVGDMVLGAVNLFLVLPIFWYILTEVWLASFLRHNFGFYCGMFIASIILILPLVRYEAVFVSAKLHTTVAINVAIIPILCSVAMLIRICRIFKSMRQGTDYVPVSETVELELESEPRPRPSRTPSPGRNRRRSSTSSSSSRSTRRQRPVSTQALISSVLPMTTDSEEEIFP
What is the function of this protein?
Envelope glycoprotein important for virion assembly and egress.  Plays a role in the correct incorporation of gH-gL into virion membrane.  Directs the glycoprotein N (gN) to the host trans-Golgi network.
What are the official names of this protein?
Envelope glycoprotein M, gM.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein M family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.
Protein: Y019_PROM1
Sequence: MAGFGLPNFGQLTEAFKKAQQIQQNAQKLQEELEVMEIEGTNDDNRAKIWMSGNQKPLRVEIDPSLLSEGKAIIEEAILEAMKSAHEVSTSTMKERMEDLTGGFKLNLPGMGEES
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein NATL1_00191.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PYRH_PSEU2
Sequence: MAQQGSGYQARYKRILLKLSGEALMGSEEFGIDPKVLDRMALEVGQLVGIGVQVGLVIGGGNLFRGAALSAAGMDRVTGDHMGMLATVMNALAMRDALERANITAIVMSAISMVGVTDHYDRRKAMRHLSAKEVVIFAAGTGNPFFTTDSAACLRAIEIDADVVLKATKVDGVYTADPFKDPNAEKFDHLTYDEVLDRKLGVMDLTAICLCRDHKMPLRVFNMNKPGALLNIVHGGAEGTLIEEAQ
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FI_LAMBD
Sequence: MTKDELIARLRSLGEQLNRDVSLTGTKEELALRVAELKEELDDTDETAGQDTPLSRENVLTGHENEVGSAQPDTVILDTSELVTVVALVKLHTDALHATRDEPVAFVLPGTAFRVSAGVAAEMTERGLARMQ
What is the function of this protein?
Stimulates the interaction of procapsid with the terminase-DNA complex, thereby increasing the overall rate of DNA packaging.  Before packaging, it likely coats the surface of the procapsid through binding mediated by C-terminal domain.  FI presumably dissociates from the capsid once it inflates upon DNA packaging, and is not present in the mature virion.
What are the official names of this protein?
DNA-packaging protein FI.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: RRF_STRS2
Sequence: MSKEIIAKAQERMNQSHQSLAREFSHIRAGRANASLLDRISVEYYGSPTPLNQLAGITVPEARVLLITPFDKSILKDIERALNASDLGLTPQSDGTVIRLVIPALTEETRKNLAKDVKKVGENSKVAIRNIRRDAMDEAKKAEKAKEITEDELKTLEKDIQKVTDDAIKTIDKMTADKEKELLEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RACF2_DICDI
Sequence: MQNIKCVVVGDGAVGKTCMLISYTTNGFPSEYLPTVFDNYCANLMLDGKPYSLGLWDTAGQEEYDRLRPLSYPQTDVFLICFSIISQSSFENVSTKWFKEVNHHAPGVPIVLVGTKQDIRNDNDSIKKLKERNIELVPYEKGLEKAKEINAIYLEASALTQRGVKNVFDQCIRSVIYPNKLNKKPKKKTCTIM
What are the official names of this protein?
Rho-related protein racF2.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: SIR_DESVH
Sequence: MSDEPKGAILQRDKLTYAIVPRTPCGLLTPDVLDAVSRVCRKYEVPIIKITSGQRLALVGMKKEAVEPMWEELRLDVGRAVELCVHYVQACPGTAVCRFGLQDSLGIGVAIEEEYVGHDFPAKVKFGISGCPFCCGESYLRDVGLVGTKKGWTLIVGGNSGGHPRIGDVLAEELSTDEAKGLIRKFMEFYRDNSGKRLRVSKFVEKTGIEAIRQAVLG
What is the function of this protein?
This enzyme catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase, assimilatory-type.
Protein: DCYD_SALTY
Sequence: MPLHHLTRFPRLEFIGAPTPLEYLPRLSDYLGREIYIKRDDVTPIAMGGNKLRKLEFLVADALREGADTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALTDPDAQLQTLATRIEAQGFRPYVIPVGGSSALGAMGYVESALEIAQQCEEVVGLSSVVVASGSAGTHAGLAVGLEHLMPDVELIGVTVSRSVAEQKPKVIALQQAIAGQLALTATADIHLWDDYFAPGYGVPNDAGMEAVKLLASLEGVLLDPVYTGKAMAGLIDGISQKRFNDDGPILFIHTGGAPALFAYHPHV
What is the function of this protein?
Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives.  It could be a defense mechanism against D-cysteine.
What are the official names of this protein?
D-cysteine desulfhydrase.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: YK165_YEAST
Sequence: MQFPVFFFRCFSYGISSMPLKNKVVFNENMERKDTFYQLILKVLSALLLLSVRNSSGHTRHFVQSSEKIYRRSLFKQ
What are the official names of this protein?
Putative uncharacterized YKL165C-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PAFA_MYCBO
Sequence: MQRRIMGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATAECDSLVQLVTHDRAGEWVLEDLLVDAEQRLADEGIGGDIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKAATYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMSETTTMLKVGTAALVLEMIESGVAFRDFSLDNPIRAIREVSHDVTGRRPVRLAGGRQASALDIQREYYTRAVEHLQTREPNAQIEQVVDLWGRQLDAVESQDFAKVDTEIDWVIKRKLFQRYQDRYDMELSHPKIAQLDLAYHDIKRGRGIFDLLQRKGLAARVTTDEEIAEAVDQPPQTTRARLRGEFISAAQEAGRDFTVDWVHLKLNDQAQRTVLCKDPFRAVDERVKRLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: AGALB_ASPCL
Sequence: MSRFHLPLAAAVVLVSCLWSANALVRPDGVGKLPALGWNSWNAFGCDIDDAKIMTAAKEIVNLGLKDLGYEYINIDDCWSVKSGRDKTTKRIVPDPAKFPDGIAGVADRIHDLGLKVGIYSSAGLTTCAGYPASLGYEEIDAQTFAEWGIDYLKYDNCGVPSNWTDAYTFCVPDPGSASTNGTCPDNENPAPQGYDWSTSLTAQRHQRMRDALLGVEHTIFYSLCEWGQADVSAWGNATGNSWRMSGDITPSWDRIAAIANENSFLLNHVDFWGHSDPDMLEVGNGDLTLAENRAHFALWAAMKSPLIIGTALDGIDPAHLEILLNKYLIAFHQDPVIGRPAYPYKWGYSPDWTFDPAHPAEYWSGPSSTLDGTLVLMLNSEGSRQTRTAVWKEIPELKDALGRKGRRQTGFRVTDVWTGKDLGCVRDHYTVTLESHDVAALLVGKGC
What is the function of this protein?
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
What are the official names of this protein?
Probable alpha-galactosidase B, Melibiase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RK20_CUSGR
Sequence: MTRIKRGSIARARRTKIRFFASKFRGSHSRLTRTIIQQGLRAFVSSQRDRHKKKRDFRRLWITRLNAAIRAIGVGYSYSASIHNLYKSQLILNRKILTQIAISNRNCLYMISNEILKSGV
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20, plastid.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid.
Protein: PETD_PEA
Sequence: MGVTKKPDLTDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTIACNVGLAVLEPSMIGEPADPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMVSVPAGLLTVPFLENVNKFQNPFRRPVATTVFLIGTVVALWLGIGATLPIEKSLTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: P2RY2_MOUSE
Sequence: MAADLEPWNSTINGTWEGDELGYKCRFNEDFKYVLLPVSYGVVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLHSLRWGRARYARRVAAVVWVLVLACQAPVLYFVTTSVRGTRITCHDTSARELFSHFVAYSSVMLGLLFAVPFSVILVCYVLMARRLLKPAYGTTGGLPRAKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTEPTPSPQARRKLGLHRPNRTVRKDLSVSSDDSRRTESTPAGSETKDIRL
What is the function of this protein?
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system.  The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
What are the official names of this protein?
P2Y purinoceptor 2, P2Y2, ATP receptor, P2U purinoceptor 1, P2U1, Purinergic receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PFA5_ASPFU
Sequence: MARRAADKRVNLAVSRIIPPILIGVFGYASYAITKPLCVDYLIHPAHHYDRRSRSGAGAAILAIYYVLLIPVLATYLRLLYNVVLSPGYLPRGTACTQNQTGSDGSKHRHRRHRRRKSGHHLSKTTEKTDRSDGGDVERGLEYSARAKAYPLDAEGLESFYTKDVFVCQPDGRPVYCSTCCQFKTDRAHHCREVDRCVRKMDHFCPWVGGVVSETSFKFFIQFIVYTMIYCIFVLIVFAIYTAELRREAGRTNVHWIVCLALSSLFGFFTFGVAISSVQLAANNLTTIENLNRRSAVWTLAIRVPRHILSKRWAPTFRTITYPLPPVPPAESEVARESPGGEQHVFAILQTLPGENPFDLGSPLKNIQQVMGFSLLEWLLPIKQSPCADHSSNESAFALGPVVTRLKKEAGLEVSTESESADPVGAAETPQHEQRRGKHRRRN
What are the official names of this protein?
Palmitoyltransferase pfa5, Protein fatty acyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DB119_MACFA
Sequence: MKFLFLFLAILLATKIPVISGKRHNLRCMGNSGICRASCKKNEQPYLYCRNYQACCLQSYMRISISGKEENTDWSYEKQWPRLP
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 119, Beta-defensin 120, Defensin, beta 119, Defensin, beta 120.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: BATF3_HUMAN
Sequence: MSQGLPAAGSVLQRSVAAPGNQPQPQPQQQSPEDDDRKVRRREKNRVAAQRSRKKQTQKADKLHEEYESLEQENTMLRREIGKLTEELKHLTEALKEHEKMCPLLLCPMNFVPVPPRPDPVAGCLPR
What is the function of this protein?
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system.  Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity).  Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
What are the official names of this protein?
Basic leucine zipper transcriptional factor ATF-like 3, B-ATF-3, 21 kDa small nuclear factor isolated from T-cells, Jun dimerization protein p21SNFT.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HTPG_MYCA1
Sequence: MNARVEQLEFQAEARQLLDLMVHSVYSNKDSFLRELISNASDALDKLRLEAFRNKDLDVDTSDLHIQIEVDKDARTLTIRDNGIGMTRAEVVDLIGTLAKSGTAELRQQLREAKNAQNEAASEELIGQFGIGFYSSFMVADKVELLTRKAGESEATKWESSGEGTYTIESVENAPQGTSVTLHLKPEDTEDELHDYTSEFKIKSLVKKYSDFIAWPIRMEVERRTPATEEGGEETVTREVETLNSMKALWARPKDEVSEEEYKEFYKHIAHAWDDPLEVIAMKAEGTFEYQALLFIPSHAPFDLFNRDAHTGIQLYVKRVFIMGDCDQLMPEYLRFVKGVVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKELQSERPDDYRTFWTQFGRVVKEGLLSDFDNQETLLQLCSFASTHSEEEATTLAQYVERMKEGQTQIFYATGETRQQILKSPHLEAFKAKGYEVLLLTDPVDEVWVGTVTEFDGKPLQSIAKGEVDLSAEGEESQAEREEQQKEFADLLAWLKDTLSDHVKEVRLSNRLTDSPACLITDAFGITPALARLYRASGQDIPVGKRILELNPKHPLVTGLRQAHQDRADDPSVAETAELLYGTALLAEGGALDDPARFAEILADRLARTL
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDN4_ODOLI
Sequence: MFTMKKSLLVLFFLGTISLSLCVEERDADEEDNGEVEEVKRGVFTLIKGATQLIGKTLGKELGKTGLELMACKITNQC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Lividin-4.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL31B_BIFLS
Sequence: MQEGIHPEYGPVVFYDRSADKYFLTKSTLVAKAVNLPTIDWEDGNTYPLVNVEVSSYSHPFYTGKNVVIDAAGQVQKFNARYGRK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: MFM8_PHOSM
Sequence: MDFPGNSRFASFVRADFEYSRVEDHPLIASVLSPRKAEESAQRQSPVLVFWHGGGFVVGGRLYEPWWSEWLIEYALSQDAIIVAPDYRLLPEATGADIFDDVEAFWIWLHKSLPSLAQSNSWHAKPDLTRILCVGQSGGGSMAVHSALLHPEFNIKAIVSLYAPLYHNVPNLTVPRPRRILGTMPPPPRKAEGLIRSYIKQSKGSVRTGGDPLDMWELLLCLLQQGRLISLMNLKPDSRLDTPSLLRQVGKLPPLWLIHGEDDSVIPFKCSEMFLDELRVIAPSTSVLVSARTGEHNFDTSLTMKEDWIRNGCDFLSTHW
What is the function of this protein?
Probable carboxylesterase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS) (PubMed:27056201).  SQS1 is composed of a 2,8-dioxobicyclic[3. 2. 1]octane-3,4,5-tricarboxyclic acid core that is connected to two lipophilic polyketide arms (PubMed:27056201).  These initial steps feature the priming of an unusual benzoic acid starter unit onto the highly reducing polyketide synthase pks2, followed by oxaloacetate extension and product release to generate a tricarboxylic acid containing product (By similarity).  The phenylalanine ammonia lyase (PAL) M7 and the acyl-CoA ligase M9 are involved in transforming phenylalanine into benzoyl-CoA (By similarity).  The citrate synthase-like protein R3 is involved in connecting the C-alpha-carbons of the hexaketide chain and oxaloacetate to afford the tricarboxylic acid unit (By similarity).  The potential hydrolytic enzymes, M8 and M10, are in close proximity to pks2 and may participate in product release (By similarity).  On the other side, the tetraketide arm is synthesized by a the squalestatin tetraketide synthase pks1 and enzymatically esterified to the core in the last biosynthetic step, by the acetyltransferase M4 (PubMed:11251290, PubMed:15489970, PubMed:28106181).  The biosynthesis of the tetraketide must involve 3 rounds of chain extension (PubMed:11251290, PubMed:15489970, PubMed:28106181).  After the first and second rounds methyl-transfer occurs, and in all rounds of extension the ketoreductase and dehydratase are active (PubMed:11251290, PubMed:15489970, PubMed:28106181).  The enoyl reductase and C-MeT of pks1 are not active in the final round of extension (PubMed:11251290, PubMed:15489970, PubMed:28106181).  The acetyltransferase M4 appears to have a broad substrate selectivity for its acyl CoA substrate, allowing the in vitro synthesis of novel squalestatins (Probable).  The biosynthesis of SQS1 requires several oxidative steps likely performed by oxidoreductases M1, R1 and R2 (Probable).  Finally, in support of the identification of the cluster as being responsible for SQS1 production, the cluster contains a gene encoding a putative squalene synthase (SS) R6, suggesting a likely mechanism for self-resistance (Probable).
What are the official names of this protein?
Probable carboxylesterase M8, Squalestatin S1 biosynthesis cluster protein M8.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
Protein: MSH5_YEAST
Sequence: MSHEWLISASETMRSIGNGEGLRDKGAVVANNDGEFNEGDTNREEDSSTIFSFDFDEEIVMCIDFSGGKLGCSILDYHTKTLKAFDQDYVVNKTTISSHDLIDDADMSSNDISLLLGLLIMEANPTVCLVPARLEDWIFDYIKTKCDEINCRLELQPIKRFKKWDLLQSLQLRGHDNQTILNDILSNSKFTTTVTLGTVGCILANHEQLGEYNDSTASSNMVTGRLVQNAFEDVIHGIRYIDIRDRMVLDENTISALHIFPTAHKLGHDKMMRNGFFSVFELFNQVSSDYARRILKSWLINPLTNKKRIETRYSIIRTLLDKQNAIIFSDLSQSIKRCPDAFGFINQLRSGKSTLGTWSKVASFLEKGIAIFQLVSSLKLGSDEANILHDIKNKVDISALKECLRKVETVIDFDTSRDTKTLTINTGVDNRLDECRNIYNHLEGILLDVARETQIFLLNTMPQEDCKTTKSLEKLVNAVYIPQLGYLVTISVLMEPLLDGIPNLQWEEIFRSSENIYFKNGRVLELDETYGDIYGAISDFEIEILFSLQEQILRRKTQLTAYNILLSELEILLSFAQVSAERNYAEPQLVEDECILEIINGRHALYETFLDNYIPNSTMIDGGLFSELSWCEQNKGRIIVVTGANASGKSVYLTQNGLIVYLAQIGCFVPAERARIGIADKILTRIRTQETVYKTQSSFLLDSQQMAKSLSLATEKSLILIDEYGKGTDILDGPSLFGSIMLNMSKSEKCPRIIACTHFHELFNENVLTENIKGIKHYCTDILISQKYNLLETAHVGEDHESEGITFLFKVKEGISKQSFGIYCAKVCGLSRDIVERAEELSRMINRGDDVVQQCGNLTEKEMREFQKNQEIVKKFLSWDLDLETTTTSENLRLKLKNFLR
What is the function of this protein?
Involved in meiotic recombination.  Facilitate crossovers between homologs during meiosis.
What are the official names of this protein?
MutS protein homolog 5.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: Y6364_DICDI
Sequence: MIINNQNSPQSINTPSSVSSRQHINKSKKKKENVIKRMLIRLSNSNNRSLATVFGVIGGLVLGIVLVCKEYENFPLVGKGLPLVYRIVGIFLSAGTGGNLSSYIGGTIDIITGDKTVVDLYKSFKRYFKKVKDKNHRSPIPLTNLNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSGGSGSTDNNNNNNEPIFSNNNSNNNNDNNSDLEIPIPI
What are the official names of this protein?
Putative uncharacterized protein DDB_G0285135.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS20_STRPN
Sequence: MANIKSAIKRAELNVKQNEKNSAQKSAMRTAIKAFEANPSEELFRAASSAIDKAETKGLIHKNKASRDKARLSAKLVK
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: YHAM_BACCQ
Sequence: MKKKIAEYEVGEQVDVFLLIKTATKGIASNGKPFLTVILQDPSGDIEAKLWDVSPEVEKQYVAETIVKVAGDILNYKGRIQLRVKQIRVANENEVTDISDFVEKAPVKKEDMVEKITQYIFEMRNPNIQRLTRHLLNKHQNEFLDYPAATKNHHEFVSGLAYHVVSMLDLAKAISNLYPSLDKDLLYAGVILHDLGKVIELSGPISTTYTLEGNLLGHISIMVNEIGKAADELQIDAEEVLILQHIVLSHHGKAEWGSPKPPLVKEAEILHYIDNLDAKMNMMDRALGRTKPGEYTERVFALDNRSFYKPSFHN
What is the function of this protein?
Shows a 3'-5' exoribonuclease activity.
What are the official names of this protein?
3'-5' exoribonuclease YhaM.
What is the protein family that this protein belongs to?
Belongs to the YhaM family.
Protein: LECB1_MACPO
Sequence: NGPNGKSQSIIVGPWGDRVTN
What is the function of this protein?
D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc.
What are the official names of this protein?
Agglutinin beta-1 chain, MPA.
What is the protein family that this protein belongs to?
Belongs to the jacalin lectin family.