PharMolix/UniProtQA huggingface dataset:
Protein: NDK_FRAT1
Sequence: MTKQRTLSIIKPDAVEKNVIGEIYSRFEKAGLRIIAAKMKHLSKAEAERFYAVHKDRPFFSALVEFMISGPVMIQVLEGENAIAKNRELMGATNPKEAKAGTIRADFADSIDANAVHGSDAEDTAAQEIRYFFSDTEIFG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCA3_MESMA
Sequence: MNYLVFFSLALLLMTGVESVRDGYIADDKNCAYFCGRNAYCDDECKKKGAESGYCQWAGVYGNACWCYKLPDKVPIRVPGKCNGG
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Toxin BmKa3, Alpha-toxin 3, BmKalpha3.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LCL2_AJECN
Sequence: MVRIFTSILLGLLLLVTGTRSQFQFFEQMFGGGQQQQHDSREQNVPSDSDWYQRTYDNARCSNYLCPGTLACVAVPHHCPCQHPAVEDKFELGDGSAICVSKGGFKFGEAARKVELARKGLL
What is the function of this protein?
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
What are the official names of this protein?
Long chronological lifespan protein 2.
What is the protein family that this protein belongs to?
Belongs to the LCL2 family.
Protein: BBS1_CAEEL
Sequence: MAKPVNVNQSKWTVPVLLKECEIYCPSTCVAFGPILSDNDSKLIIAHGGHRGVNMKLKVFQQLEQLSESSLADMPTALVHFINDLSSIPSIAVAAGPSLLIYKNLKPFYKFTVPSSAINPTESEAWKAVVNKKINGDTLLTVLKRLEDDVAFSKLTPISQTYLRADKETQVVLVEHYGTKIANSATITCIAKLTKSTAEPLDILVIGTEHCEIFLIDSQAFTILETIKIGSVPVNICAYGTYDVDYRLFVQTRASLIFCMKRGEADYQPIVISQSMITSMVLVNKMIVYTTVENLIHFASFRGKKMNTVKCPSKIKMLEPFIYPLKQLAAVIAVFDKEIRMYNEHYLLDTVQYEKPLAWVKYGCYGREDSTLVVAFKDGSIAIQIFRRKANFDTKLDYNQVPQAHALKLQIPKKTKVFIDLTQREVQLGNRIHKVYQKNLFDVKYRLAASYLELTSSASATVSTTTVLPVEISVDIHGFGPTFRMTIHLLSSSKQNLYDMHLSIISDPELYDFDTPLIPVHLLASGQSYSFTTLLYCKDPEKAANCDVRALLVHAKRATPIVTAVIKMPFSEFPLD
What is the function of this protein?
Component of the BBSome complex (By similarity).  The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity).  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity).  Required for proper BBSome complex assembly and its ciliary localization (PubMed:22922713).  Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:15231740, PubMed:22022287, PubMed:22922713).
What are the official names of this protein?
Bardet-Biedl syndrome 1 protein homolog.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme.
Protein: Y210_METM6
Sequence: MREVLLSECIDLLYESHFVISKPFGRSCFDLIAKKADLRFLIKILKNIDSLSTEQSEELLNIAKMLQAVPIIIGTRTRNSVMEEGAVYERYGIKAITFNTFRDQLSGEPPVVYANRGGFFVNIDGAVLRETREKLKISVGELAEISRVSRKTIYKYEQNEANPSAEVAIKIEEYLDVPLIKGINIVDYMEGLKSQKSREEAFEKILKEGEDFKIRVIDILGDMGFNLLETTKAPFDAVAEESKIEDSENQNIIFTNIQETENEEIRRKAMIVDEISKMLNSHSLLVLEKKTNENKRITSMSISELEKIGDTVDLLEFIEKRKKSKEI
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein MmarC6_0210.
Protein: NRFA_SALHS
Sequence: MARKTLRARRFFSLIFPFFFITSVYAEQTPESAKTVTVEAKNEMFAPQHPDQYQSWKATSEQSAREDALAEDPRLVILWAGYPFSRDYNKPRGHAYAVTDVRETLRTGAPKTAEDGPLPMACWSCKSPDVARLIQQEGEDGYFHGKWARGGPEIVNDLGCADCHNTASDDFAQGKPALTLSRPYAERAMEAIGKPFDKAGRFDQQSMVCGQCHVEYYFDGKNKAVKFPWDEGMKVENMEQYYDAIAFSDWTNSLSKTPMLKAQHPEYETWSAGIHGKNNVTCIDCHMPKVQNAEGKLYTDHKIGNPFDNFAQTCANCHTQDKASLQKVVAERKQAIHDLKIKVEDQLVHAHFEAKAAWDAGATDAEMKPILNDIRHAQWRWDLAIASHGIHMHAPEEGLRMLGSAMDKAADARTKLARLLATKGITHEIPLPDISTKEKAQKAIGLNMQQINAEKQDFLKTVVPQWEDQARKNGLLSQ
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: COX2_PANPA
Sequence: MAHAAQVGLQDATSPIMEELIIFHDHALMIIFLICFLVLYALFLTLTTKLTNTSISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSFTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRLVLPVEAPVRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KTHY_TRIL1
Sequence: MFITFEGIEGCGKSTQIALLAASLQQAGQRVLLTREPGGCPIADQIRSVLLDAANTALVPMAELMLYAASRAQHLAEVVSPALAEGVIVLCDRFSDATRAYQSFGRGIDRQVIETLNSLACDGISPDLTVLLDCPVETGLGRARQRIDSTSGPREERFELESLAFHQRVRDGYLQLAAEEPGRFVIVDATVQPAQVASAISDAVLSRLAVPV
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RPOB_SHESM
Sequence: MVYSYSEKKRIRKDFGKRPQVLDIPYLLSIQLDSFKKFTDQDPTGERGLEAAFRSVFPIKSFSGNSELQYVSYKLGEPVFDVKECQIRGVTYSAPLRVKLRMVLYDREAAAGTVKDIKEQEVYMGDIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDHDRGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDALFVRIDRRRKLPATIILRALEYSTQEILDLFFERVEFKIKKDTLVMTLVPERLRGETASYDIKDAEGSVLVEAGRRITARHIRQLEKTNTTELEVPVEYIVGKYAAQDYIDPDTGEVLVSANSEISLEDLAKLSLAGIKELSTLYINELDHGAYISDTLRIDPTTNRLEALVEIYRMMRPGEPPTKDAAEALFQNLFFSEERYDLSKVGRMKFNRRLSIPDDEGSGVLSKEDIVAVMKNIIHIRNGFDEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVRERLSLGDLNELMPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHPTHYGRLCPIETPEGPNIGLINSLASFARTNSYGFLETPYRKVVDGVITDDVEYLSAIEEGRYVIAQANIEVDSQGRMVEEQIACRHKGESTFMRASDIQYMDVSPQQIISVAASLIPFLEHDDANRALMGANMQRQAVPTLKSEKPLVGTGIERTLAVDSGVVVAAKRGGVIDYVDASRIVVKVNEDELRPGEAGIDIYNLTKYTRSNQNTCINQRPCCSVGEPVVRGDVLADGPSTDLGDLALGQNMRIAFMPWNGYNFEDSILISERVAQEDRFTTIHIQELSCIARDTKLGSEEITADIPNVGESALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVKGTIIDVQVFTRDGVEKDKRAIEIEEMHIAQARKDLGEEFKILEEGVLSRARNLLLSAGFTEAQIAALPRKDVLVQVIDDETKQTELEQLAEQHEELKADFDKKFEIKRRKITQGDDLAPGVLKIVKVYLAVKRTIQPGDKMAGRHGNKGVISKINPIEDMPYDEQGNPVDIVLNPLGVPSRMNIGQVLEVHLGAAAKGIGNKIAAMLEDQREKGLAEVRSYIKQVYELGDEVQQRVDIDSFTDDELLRLANNLKGGIPVATPAFDGAKEKEIKQMLELAGLPTSGQLKLFDGRTGNEFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTQMYKNIVDGNHQMQPGMPESFNVLLKEIRSLGINIELDQE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: SECA_FINM2
Sequence: MGVFESIFGSANKKELKKIEPIIKKIESYDKSMQQLSDDELKHKTVEFKERLKNGETLDDILPEAFAVVREASYRVLGMKQYRVQLIGGVVLHQGRIAEMKTGEGKTLVATLPAYLNALSGKGVHVVTVNDYLAKRDKEWMGKVHEFLGLTVGVIVYGLDNDERRENYACDITYGTNNQYGFDYLRDNMVIYKKDKVQRGLNFAIVDEVDSILIDEARTPLIISGQGDESTDMYMRANMFANGLTGRIMDPEEDKPDIFDREFKDETVDFLVDEKRKTASLTEVGTRKAEEYFGVENLSDPNNMELAHHINQALKANNTMKRDIDYVVKDDEILIVDEFTGRIMEGRRYSDGLHQAIEAKEGVEVKSESKTLATVTFQNYFRMYNKLSGMTGTAKTEEAEFNEIYKMDVVEIPTNKPVARVDEQDRVYINENAKFNAIVEEIKEIHKTGQPILVGTISIEVSERLSNLLKKNGIKHDVLNAKQHEREAEIVAQAGMFDKVTIATNMAGRGTDILLGGNPDFMAKHDMKKQGYGDYVIESLDSFLPSTDEELVAARNVYNELHKKYKKMTDENKKKVLEVGGLYIIGTERHESRRIDNQLRGRSGRQGDPGRSRFFVSLGDNLMRLFGGETIQKYAESGKFPEDEPMEFRTITKAIERAQTKVESNNFGIRKNVLKYDDVMNAQRKVIYTERDKVLDGEDMHESIVAMIKDIISNAIDTYCQDPKSENWEMEALMTYLNTFIPEGTLDLTRLNSYNKKTFTDYVIQKALEVYNAKEEAIGKEKFREIERVILLMVVDRKWMDHIDAMDQLRQGIGLRAFGQQDPVRAYNNEGFEMFEDMNHSIKEDTVRGMFNVQPVEEIERKQVAHETSATGGEEEINKPVVKGKKIGRNDPCPCGSGKKYKNCCGKNR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: YIDD_SHEB2
Sequence: MAQTQSPLQWLATTLIRGYQVFISPILGPRCRFNPTCSHYAIEAIKVHGTAKGCWFALKRILKCHPLHPGGSDPVPPKNDRCNK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: COBQ_MYCPA
Sequence: MSGALLVAGTSSDAGKSVVVAGLCRLLARRGVRVAPFKAQNMSNNSAVTVEGGEIGRAQAIQARAAGLEPSVRFNPILLKPGSDRTSQLVIKGQVAESVTATSYVQHRDRLAALVLNELTCLRDEFDAVICEGAGSPAEINLRATDLANMGLARAADLAVILVGDIDRGGLLAHLFGTVAVLDPQDQALIAGFVVNKFRGDPALLQPGLRRLHDITGRPTYGVLPYADRLWLDAEDSLSVLAHRVVGAPDPPLGDDWLRVAAVRLPRISNSTDVEALACEPGVLVRWVSEPSDVADADLVVIPGSKATVADLSWLRERGLAAAITAHAAAGRPVLGICGGFQMLCRRIDDRVESGAGEVAGLGLLDADIAFHPAKTLRRWQRPLAGYEIHHGRVSRCAEHSWFDSDAEPQGLVRGAVFGTHWHGLLDNDDFRRAWLVRVADAAGRRFVPGDTDVAARRDAQLDLAADLLAAHLDVDAVLGLLDGPPPRPRLATRLCR
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: CLFA_STAA8
Sequence: MNMKKKEKHAIRKKSIGVASVLVGTLIGFGLLSSKEADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSSSTNATTEETPVTGEATTTTTNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQDTSTEATPSNNESAPQSTDASNKDVVNQAVNTSAPRMRAFSLAAVAADAPVAGTDITNQLTNVTVGIDSGTTVYPHQAGYVKLNYGFSVPNSAVKGDTFKITVPKELNLNGVTSTAKVPPIMAGDQVLANGVIDSDGNVIYTFTDYVNTKDDVKATLTMPAYIDPENVKKTGNVTLATGIGSTTANKTVLVDYEKYGKFYNLSIKGTIDQIDKTNNTYRQTIYVNPSGDNVIAPVLTGNLKPNTDSNALIDQQNTSIKVYKVDNAADLSESYFVNPENFEDVTNSVNITFPNPNQYKVEFNTPDDQITTPYIVVVNGHIDPNSKGDLALRSTLYGYNSNIIWRSMSWDNEVAFNNGSGSGDGIDKPVVPEQPDEPGEIEPIPEDSDSDPGSDSGSDSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSDNDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSDSDSDSDSDSDSDSDSDSASDSDSGSDSDSSSDSDSESDSNSDSESVSNNNVVPPNSPKNGTNASNKNEAKDSKEPLPDTGSEDEANTSLIWGLLASIGSLLLFRRKKENKDKK
What is the function of this protein?
Cell surface-associated protein implicated in virulence.  Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen.  Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing.  Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed.  Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis.  Enhances spleen cell proliferative response in vitro, contributing significantly to the immunostimulatory activity of S. aureus.
What are the official names of this protein?
Clumping factor A, Fibrinogen receptor A, Fibrinogen-binding protein A.
What is the protein family that this protein belongs to?
Belongs to the serine-aspartate repeat-containing protein (SDr) family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Found in a ring-like distribution on the cell surface (PubMed:18800056). Does not localize with SasF (PubMed:18800056). Exchanging the ClfA and SasF signal peptides retargets the mature protein on the cell surface (PubMed:18800056). Anchored to the cell wall by sortase A (Probable).
Protein: NP1L4_MOUSE
Sequence: MAENSLSDGGPADSVEAAKNASNTEKLTDQVMQNPQVLAALQERLDNVSHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAESAWHSENEEEDKLAGDMKNKVVIAEKEAATVEELNPKGIPEFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNPVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGTVRTITKQVPNESFFNFFSPLKASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGDEEGEDEDDADVNPKV
What is the function of this protein?
Acts as histone chaperone in nucleosome assembly (PubMed:28366643).  In condensing spermatids, mediates the loading of the heterodimer composed of histones H2AB1 and H2BC1/TH2B onto the nucleosomes, thereby promoting the replacement of histones to protamine in male germ cells (PubMed:28366643).
What are the official names of this protein?
Nucleosome assembly protein 1-like 4.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Present in the cytoplasm and excluded from the nucleus during G0/G1 phase, then relocates to the nucleus by the time cells are in S phase. Phosphorylated form localizes in the cytoplasm during the G0/G1 transition, whereas dephosphorylation leads to relocalization into the nucleus at the G1/S-boundary.
Protein: YI20A_YEAST
Sequence: MPHSEKLKGKKEKAFFFLPRKFNLPTGVPIGVRKRSLGITAVRTYSGAGVGTQSGIPKVLWYKTPYLKHKTNLTRGSFYS
What are the official names of this protein?
Putative uncharacterized protein YIR020W-A.
Protein: UPP_STREM
Sequence: MGKCQVISHPLIQHKLSILRRQDTSTKDFRELVNEIAMLMGYEVSRDLPLEDVEIQTPVAKTVQKQLAGKKLAIVPILRAGIGMVDGFLSLVPAAKVGHIGMYRNEETLEPVEYLVKLPEDIDQRQIFIVDPMLATGGSAILAVDSLKKRGAANIKFVCLVAAPEGVKKLQEAHPDVDIYTAALDERLNDHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: HJC_HALVD
Sequence: MSSNRKGDRRERELVNALDEAGFAVMRAPASGSATTRELPDVLAGNGEVFYAIEAKASSGRPIYLSGEEVEALVYFSRNFGAKARIAVRFDREDWYFFHPGDLYVTDGGNYRVKKETALAEGEDFESFTGGPTQTKLGGD
What is the function of this protein?
A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination.  Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products (By similarity).  Has a role that partially overlaps that of Hef endonuclease; double deletions cannot be constructed.  In the presence of site-directed mutations that (probably) abolish Hef helicase or nuclease activity, a hjc deletion cannot be constructed.
What are the official names of this protein?
Holliday junction resolvase Hjc, Hjc.
What is the protein family that this protein belongs to?
Belongs to the Holliday junction resolvase Hjc family.
Protein: M2_I80AA
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRLFKHGLKRGPSTEGVPESMREEYREEQQNAVDADDGHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: PSBD_NEPOL
Sequence: MTIAIGTPEEKRGLFDDMDDWLRRDRFVFVGWSGLLLLPCAYFAVGGWLTGTTFVTSWYTHGLASSYLEGCNVLTAAVSTPANSMAHSLLLLWGPEAQGDFTRWCQLGGLWTFIALHGSFGLIGFMLRQFEIARAIGLRPYNAIAFSGPISVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGIAFSNKRWLHFFMLFVPVTGLWMSAIGVVGLALNLRAYDFVSQELRAAEDPEFETFYTKNLLLNEGIRAWMAAQDQPHEKLVFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y5550_RICCK
Sequence: MVNFNQFLKQAQSMQKKMQEAQEQMVNARYTGKAGGRLVEITITGRSEVEKVSIDESLLKAEEKEMLEDLIKVAFNDAKQKCDEDSQNSLSGALNGINLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein A1E_05550.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RECO_DESAP
Sequence: MKQYQTEAIVLRASAVREADRTLVLLTRDRGKLRVWAHGAARPTSRKRGAVQPFCRSRFLLERGREIDVVRQAEALEEFPALHADLEALALAGYVCELAEGFAAEGQAEPGIYGLLLQVLRRLAEDKSGLPVRFFEARILALTGFGPELGSCAGCGAQPVVPARFSPALGGVLCRGCRDRDPPARPCRSAVVQVLGKLLEWPLDRLKVLRIDAATGREVADILQACVCHHLEREPRSLAFLRKMGISSS
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: TR16L_HUMAN
Sequence: MQFGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRSAEMEKSKQELETMAAISNTVQFLEEYCKFKNTEDITFPSVYIGLKDKLSGIRKVITESTVHLIQLLENYKKKLQEFSKEEEYDIRTQVSAIVQRKYWTSKPEPSTREQFLQYVHDITFDPDTAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGTYVGLTCKGIDQKGEERSSCISGNNFSWSLQWNGKEFTAWYSDMETPLKAGPFWRLGVYIDFPGGILSFYGVEYDSMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPSLVGTAP
What are the official names of this protein?
Tripartite motif-containing protein 16-like protein, Tripartite motif-containing protein 70.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_COXBU
Sequence: MSGGVKLIAGLGNPGDQYARTRHNVGAWFLETLAQQRNQSLAKENKFHGFVAKCNDYWLLKPTTFMNESGQAVAALAHFYKIKPSEILIAHDELDFPAGDIRLKEGGGHGGHNGLRNIIQHLGSSDFYRLRIGINHPGHKDRVTPYVLSPPSENDRIAILAAIEKGLRLIPELVQGDFQKVMRELHS
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFE_CLOLD
Sequence: MKNLWNIFKKGLIAENPIFVLALSLCPALATTSTAVNGFTMGICVLFVITCNNTVVSIIKNVVNPKVRVPVYITCIATIVTVVELVMQAYAPLLYKQLGIYLALVVVFAIILARAETFASKNPVVPSFFDGLGMGCGFTLALTIIGMIRELFGSGAIFGVNVFGASYNPALIMILPPGGFILIGYLVAIVKVYNQHMEKIKMQKLEKANGGEA
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Couples electron transfer from reduced ferredoxin to NAD(+) with translocation of H(+) out of the cell.  Essential for energy conservation during autotrophic growth.  Contributes to ATP synthesis during heterotrophic growth.
What are the official names of this protein?
Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL32_CUPMC
Sequence: MAVQQNKKSPSKRGMHRSHDHLSVAPLAVEPTTGETHLRHHVSPNGYYRGRKVIKTKND
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.