PharMolix/UniProtQA huggingface dataset:
Protein: MPRB_MYCTU
Sequence: MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDILFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGARSTDIENSRGSANVISVESQSTRAT
What is the function of this protein?
Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host.  In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA.  MprB/MprA is involved in regulation of numerous stress-responsive genes, including up-regulation of two sigma factors, sigE and sigB as well as pepD and mprA, and repression of multiple genes from regulons associated with hypoxia, starvation and iron metabolism.  The majority of genes regulated by MprB/MprA under a particular stress condition are different from those induced during normal growth, but several genes are commonly regulated under more than one condition.
What are the official names of this protein?
Signal transduction histidine-protein kinase/phosphatase MprB, Mycobacterial persistence regulator B.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ASSY_CERSK
Sequence: MSAPKKVVLAYSGGLDTSIILKWLQTEYGCEVVTFTADLGQGEELEPAREKAVMLGIKPENIFIEDVREEFVRDFVFPMFRANALYEGLYLLGTSIARPLIAKRLVEIAAQTGADAVAHGATGKGNDQVRFELTAYALDPAIKVIAPWREWDLTSRTKLLEFAEQNQIPIAKNKRGEAPFSVDANLLHTSSEGRVLENPGEEAPDYVYQRTVDPEKAPDAPEFVEIAFEKGDAVAINGEAMSPATILTKLNELGGKHGVGRLDLVENRFVGMKSRGIYETPGGTILLEAHRGIEQITLDSGAGHLKDSIMPRYAELIYNGFWYSPEREMLQALIDKSQEHVTGTVRVKLYKGFARTVARWSEHSLYSEKHVTFEEDAGAYDQKDAAGFIRLNALRLKLIATRNARVKG
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KS1_HYDVU
Sequence: MKLIIVLVMMLVCVYSMSIEKNIPKNHEVPAKKQFAETKVEKKKRSDDGDEEICDDDDEDCEDVVDIEECNEDDDDCVDGGETEECDEDDDDCQEEKKKKKRETKPKLKKRNDDEEEEECEEDDEDCEVEVDIEECDEEDDDCYDEDKKKKKENKLKKESKKKNSKKTVPKNAKKSSKRSTSTKKTSQKKQQDKRGAIQKNLKIKEANFKKKFNLNF
What is the function of this protein?
Responds to early signals of head formation in hydra.
What are the official names of this protein?
KS1 protein, Head-specific protein 1, Kopf-spezifisches protein 1.
Protein: Y2486_METPP
Sequence: MDTRLMDLLVCPICKGPLTHDHSSHELHCAADRLAFPIRDGIPVMLESEARALDESPSQAAPLSE
What are the official names of this protein?
UPF0434 protein Mpe_A2486.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: MYG_GLOME
Sequence: MGLSDGEWQLVLNVWGKVEADLAGHGQDILIRLFKGHPETLEKFDKFKHLKTEADMKASEDLKKHGNTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPAEFGADAQGAMNKALELFRKDIAAKYKELGFHG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: Y538_CORU7
Sequence: MTHGIGFDRDKYIQLQSEHINERREQIGGKLYLEMGGKLFDDYHASRVLPGFTPDNKIAMLENIKEDVEIVVCLNARDLERGKVRADLSIPYEEDALRLVDVFRDRGFRVNNVVLTQLEDSNHMAVAFAERLERLGLNVARHRVIPGYPTNTELVVSDGGFGLNDYVETSRDLVVVTAPGPGSGKLATCLSQVYHEFRRGVPAGYAKFETFPIWNLPLEHPVNLAYEAATADLDDINVIDPFHLQAYGKQVTSYNRDVEVFPLLKTLLEKLYGHSPYQSPTDMGVNMVGHCISDDELCREAAKQEIVRRYYKALVDERREDTDDTVSSRVAIVMSKVGASTKDRRVVAAANEVEERTGEPGSALELADGTIITGKTSELLGCSAAMLLNALKHLAGLDDDIHLLSPKSIEPIQTLKVDHLGSQNPRLHTDEVLIALSVSAAESEDARAALKQLKNLAGCDVHTTTILGSVDEGIFRNLGVLVTSEPKYWRKALYRKR
What are the official names of this protein?
UPF0371 protein cu0538.
What is the protein family that this protein belongs to?
Belongs to the UPF0371 family.
Protein: THIC_THEKO
Sequence: MTQLEEARKGVVTEEMKFIAEREGIDAEKLRRNVAKGYTVIFRNVRHDWVKPVAVGAGVRVKVNANIGTSRDIVDVKAEIEKAKVAVKYGADTIMDLSTGGDLDEIRKTIMHAVDVPVGTVPIYQAAEEMLAKGKAIIEMSEEDMWRAVEKHFKDGVDYTTIHVGVTKEVVEKMKRTKRAVGMVSRGGTFLAAWILHWGEENPFYKDYDYLLELAREYDVVLSLGDGLRPGGLPDAGDELQIAELYTLGRLVRRAREAGVQTMVEGPGHVPIDQIAAQVKLAKVATDNAPFYVLGPIVTDIFPGYDHITAAIGGAIAALNGADFLCYVTPAEHLGLPDVEHVRQGVIAAKIAAHAVNLTRFEADFKKDYLMALARGKLNWARQFELSMDKERFVEIRKERPTKTEACSMCGDLCAIKLINDMLAGERK
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: UVRB_LACLS
Sequence: MAIERITDNKFELVSKYDPAGDQGQAISELVENIENGEKAQILRGATGTGKTYTMSQVIAQTGKPTLVMAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYQDSVVSLRPGQEISRDQLLNDLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQVLGEVDHLAIFPATHFMTNDDRMEESIAKIEAELEAQLKVFRSEGKLLEAQRLEQRTNYDIEMLREMGYCNGVENYSRHMDGREEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGDRARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSATPGDYEMEQTDTIVEQIIRPTGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKYMHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVILYSDMAKALDENDPADKEILDSGYYTEYEGQKYKITRSMKHAMDETARRRDIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSGELEEVDASAMNKKERKALVKKLEKEMQQAAAALDFEGAAQLRDMVLELRAMD
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_RHOPS
Sequence: MSNLENLQTQILADIAASSDEAALEAVRVGALGKKGSISALLATLGKMDPEQRKTEGAAINLAKEAVTQALTARRDLLKAAALDAKLAAETIDVTLPLREPLAEQGRIHPLSQVWDELTAIFADMGFAIAEGPDIETDDNNFTRLNFPEGHPAREMHDTFYFNPKEDGSRLLLRTHTSPVQVRTMLSQRPPIRVICPGRTYRSDSDQTHTPMFHQVEGLVIDKGSHLGHLKWILAEFCKAFFEVDNVNMRFRPSFFPFTEPSLEVDIQCRRGNGEIRFGEGEDWLEILGCGMVHPNVLTACGIDPEVYQGFAWGMGIDRIAMLKYGMADLRQLFEADSRWLNHYGFKPLDIPSLAGGLSS
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAHH_AQUAE
Sequence: MEFDVKDLSLAEEGLKRIEWAEMDMPVLRQIRERFSKEKPLKGKKISACLHVTTETANLMRTLKEGGAEVYLTASNPLSTQDDVAAALVKYFEIPVFAIRGEDRETYYKHLRAVIEKEPDVVIDDGADLISTLHKEYPGLAEKVLGGMEETTTGVIRLRAMAEQGVLKFPIIAVNDAYTKHMFDNRYGTGQSTIDGILRATNRLLAGSYFVVAGYGWCGKGVAQRARGMGAIVIVTEVDPIKALEARMDGFLVMPMEEAAKLGDFFVTVTGNIHVIRREHFEVMKDGAIVANSGHFNVEIDIPALEEMAVEKREIRKEVTEYKLKDGRRIYLLAEGRLVNLAAAEGHPASVMDMSFSNQALSAEYIVKHHKELEKKVYRVPREIDEAVARLKLNALGIKIDELTEEQKKYLSSWEMGT
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y791_TREPA
Sequence: MIDDHEALLLLVLSSGPAALASLPLHPVLGKGYRNTPGALEEKAVRISCVRECLNVVQIGGRIPVLLTSAAELPRLGSCVR
What are the official names of this protein?
Uncharacterized protein TP_0791.
Protein: FST_BOVIN
Sequence: MARPRHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELQVQYQGKCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPTSSEQYLCGNDGVTYPSACHLRKATCLLGRSIGLAYEGKCIKAKSCDDIQCTGGKKCLWDFKVGRGRCSLCGELCPESKSEEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCNSISEDTEDEEEDEDQDYSFPISSILEW
What is the function of this protein?
Binds directly to activin and functions as an activin antagonist.  Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
What are the official names of this protein?
Follistatin, FS, Activin-binding protein.
What are the subcellular locations of this protein?
Secreted.
Protein: OPPF_BACSU
Sequence: MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGESGCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNPRMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIGIARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYISDRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQLKDGETMEFREVKPGHFVMCTEAEFKAFS
What is the function of this protein?
Component of the oligopeptide permease, a binding protein-dependent transport system.  Necessary for genetic competence but not sporulation.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Oligopeptide transport ATP-binding protein OppF, Stage 0 sporulation protein KE.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GATA_LACDB
Sequence: MNYLNETIDSLNDKLKSGAVSADQLAKDTIANIKKTDEKINAFITVDEDAKPAEDLDFNNKLAGVPIAIKDNIITNGLKTTAASHILYNFEPVYESTVVAKLKAAQATIIGKTNMDEFAMGSSTETSYFGDTKNPWNLNKVPGGSSGGSAAAVASGEVVAALGSDTGGSIRQPASFNGIFGIKPTYGRVSRWGLIAFASSLDQIGVMSKRVKDSAEVLNVIAGADDRDATVSEKEVPDYTSFLDKDVKGLRVAVPKEYMSDAVEEGVRKAVEAQIELLRANGAIINEVSLPHTKYVVPTYYIIASSEASANLERYDGIRYGYRAEAKNLDEVFLKSRSEGFGDEVKRRIMLGSFALSAGAYDKFFLQAAKVRTLICQDFDKIFEDNDVIVGPVSTETAFDLNSEISDQIKMYNNDILTISANMAGIPAASVPAGLSETTGMPVGFQIMAKRFDEGHVFQVADFIERSNKFYEQTPAGLED
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: DEGPL_BARHE
Sequence: MVKKTFFTTLAAVSFSAALETALFFSGCGSSLWTTKAHANSVFSSLMQQQGFADIVSQVKPAVVSVQVKSNKKKKEWFFSDFFSTPGFDQLPDQHPLKKFFQDFYNRDKPSNKSLQRSHRLRPIAFGSGFFISSDGYIVTNNHVISDGTSYAVVLDDGTELNAKLIGTDPRTDLAVLKVNEKRKFSYVDFGDDSKLRVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGTGVYDDFIQIDAAVNRGNSGGPTFDLNGKVVGVNTAIFSPSGGNVGIAFAIPAATAKQVVQQLIEKGLVQRGWLGVQIQPVTKEISDSIGLKEAKGALITDPLKGPAAKAGIKAGDVIISVNGEKINDVRDLAKRIANMSPGETVTLGVWKSGKEENIKVKLDSMPEDENMKDGSKYSNEHGNSDETLEDYGLIVAPSDDGVGLVVTDVDPDSDAADKGIRPGDVIVTVNNKSVKKVSDITDTIKNAQKLGRKAILLQVRTNDQNRFVALPIFKK
What is the function of this protein?
Could be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.
What are the official names of this protein?
Probable periplasmic serine endoprotease DegP-like, Antigen HtrA, Protease Do.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SMOC1_HUMAN
Sequence: MLPARCARLLTPHLLLVLVQLSPARGHRTTGPRFLISDRDPQCNLHCSRTQPKPICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKPLSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNIRNSEKVYSCDQERQSALEEAQQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDTGRPLPGTSTRYVMPSCESDARAKTTEADDPFKDRELPGCPEGKKMEFITSLLDALTTDMVQAINSAAPTGGGRFSEPDPSHTLEERVVHWYFSQLDSNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGCLGVSKEGRLV
What is the function of this protein?
Plays essential roles in both eye and limb development.  Probable regulator of osteoblast differentiation.
What are the official names of this protein?
SPARC-related modular calcium-binding protein 1, Secreted modular calcium-binding protein 1, SMOC-1.
Protein: NDHJ_BARVE
Sequence: MQGTLSVWLAKRGLVHRSLGFDYQGIETLQIKPEDWDSIAVILYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIEYGVNQAEEVCIKVFTHRSNPRIPSVFWVWKSTDFQERESYDMLGITYDSHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAY
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: EDN1_ATEAB
Sequence: MDYFPMIFSLLFVAFHGAPETVVLGAELSTESEQGGEQPSPSPPWRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPLRSRRSLKNSFPTKAADHRNRCRCASQKDKKCWNFCQAGKGLRLQDTMEKDWNNQKKGKDCSKLGDKCIHQQLVEGRKIRRLEAISNSIKTSFHIAKLKAELYREKKVTHNGTH
What is the function of this protein?
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity).  Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity).  Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
What are the official names of this protein?
Endothelin-1, ET-1, Preproendothelin-1, PPET1.
What is the protein family that this protein belongs to?
Belongs to the endothelin/sarafotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GSPF_ECOLI
Sequence: MNYRYRAMTQDGQKLQGIIDANDERQARLRLREEGLFLLDIRPQKSSGVKTRRPRISHSELTLFTRQLATLSAAALPLEESLAVIGQQSSNKRLGDVLNQVRSAILEGHPLSDALQHFPTLFDSLYRTLVKAGEKSGLLAPVLEKLADYNENRQKIRSKLIQSLIYPCMLTTVAIGVVIILLTAVVPKITEQFVHMKQQLPLSTRILLGLSDTLQRTGPTLLATVFIVAVGFWLWLKRGNNRHRFHAMLLRVALIGPLICAINSARYLRTLSILQSSGVPLLDGMNLSTESLNNLEIRQRLANAAENVRQGNSIHLSLEQTAIFPPMMLYMVASGEKSGQLGTLMVRAADNQETLQQNRIALTLSIFEPALIITMALIVLFIVVSVLQPLLQLNSMIN
What is the function of this protein?
Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
What are the official names of this protein?
Putative type II secretion system protein F, T2SS protein F, General secretion pathway protein F, Protein transport protein HofF.
What is the protein family that this protein belongs to?
Belongs to the GSP F family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RF1_NITSB
Sequence: MLKEKLHPFIQRYNEINELLSSPEITQDIKKMTALSKEQSEIEPIVEKAKEYMNILEAIEENRSLIEDEELGELAKEELKELEPKKEQLEEEIKVLLISKDPNDEKDIYLEIRAGTGGEEAALFASDLFKAYARYAEKKGWRVEIVSSSESDSGGYKEIIAKIKGQGVYSRLKYEAGTHRVQRVPETESQGRIHTSAVTVAIMPEVDDVDVEINPNDLKIDVYRSSGHGGQSVNTTDSAVRITHIPTGIVVAMQDEKSQHKNKEKALKILKARIFEKRMREQQEALAKDRKEQVGSGDRSERIRTYNFPQNRVTDHRIGLTLYKLEEVMQGDLDQIIEPLIAHYQAQKIQEAGL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_HALOH
Sequence: MKVEEFDYELPEELIAQKPLPNRDDSRLMVLHRKTGEIEETVFKNIIKFLEPGDLLVLNDTKVIPARLFGEKIPSGTRIEVLLLKSITEGLWEVLVRPGRRMKKGNRVSFGDGKLVGIVKDYTDFGGRIMQFEYDGDFDKVIEELGEMPLPPYITRKVEDKGRYQTVYARKKGSVAAPTAGLHFTDRLLKKIKEQGIGIIYLTLHVGLGTFRPVRAENVEDHKMHSEYFEVSTDVVNRIKETKEKGKKVIAVGTTVTRALESAAVEKRHLKAMRGWTDIFIYPGYNFKVIDGLITNFHLPKSTLLMLVSAFAGKDMVMSAYKLAIKNKYRFFSFGDAMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_MYCTO
Sequence: MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: OPTN_PONAB
Sequence: MSHQPLSCLTEKEDSPTESTGNGPPYLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTSRALSKYRSRSAEGAKNYLEHEELTVSQLLLCLREGNQKVERLEIALKEAKERVSDFEKKASNRSEIETQTEGSTEKENDEEKGLETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKSKLTVLQMTHNKLLREHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEQALASKQLQMDEMKQTIAKQEEDLETMTVLRAQMEVYCSDFHAERAAREKIHEQKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSGADQQAYLVQRGAEDRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
What is the function of this protein?
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8.  Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation.  Negatively regulates the induction of IFNB in response to RNA virus infection.  Plays a neuroprotective role in the eye and optic nerve.  Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death.  May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD).  Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment.  Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
What are the official names of this protein?
Optineurin.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans- Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy.
Protein: ELYS_HALSO
Sequence: MKLLVLCIFAMMATLAMSRRWHYVPPKFLNKAFEVALKVQIIAGFDRTLVKWLRTHGGTLSHVQKKALYFVNRRYMQTHWANYMLWINKKTDALGRTPVVGDYTRLGAEIGRRIDMDYFYNFLKGRNMIPKYLPYMEEINRMRSADIPVKYMGK
What is the function of this protein?
Dissolves the egg vitelline layer nonenzymatically during fertilization.  It creates a hole of about 3 mu-m in diameter through which the sperm pass.
What are the official names of this protein?
Egg-lysin, Sperm-lysin.
Protein: SSR5_RAT
Sequence: MEPLSLASTPSWNASAASSGNHNWSLVGSASPMGARAVLVPVLYLLVCTVGLSGNTLVIYVVLRHAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVVSYWPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKMASAAVWVFSLLMSLPLLVFADVQEGWGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAGMRVGSSRRRRSEPKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPEEPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKVLCLRRGYGMEDADAIEPRPDKSGRPQATLPTRSCEANGLMQTSRI
What is the function of this protein?
Receptor for somatostatin-28.  The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.  Increases cell growth inhibition activity of SSTR2 following heterodimerization.
What are the official names of this protein?
Somatostatin receptor type 5, SS-5-R, SS5-R, SS5R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RM34_DROME
Sequence: MLQGMLQRTCLAVVSTAQTLIVRDKHAFNRAVLKPKVRCHFPKPMEVKRINVHGWNARMSTPEGRRVLMNRILKGRHNLSH
What are the official names of this protein?
39S ribosomal protein L34, mitochondrial, L34mt, MRP-L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: VKT1_ANTEL
Sequence: INSICLLPKKQGFCRARFPRFYYNSSTRRCEMFYYGGCGGNANNFNTLEECEKVCLGYGEAWKAP
What is the function of this protein?
Dual-function toxin that inhibits both serine proteases (trypsin Kd=124 nM) and voltage-gated potassium channels rKv1. 1/KCNA1 (IC(50)=0. 9 nM).  The activity on the Kv1. 1/KCNA1 is selective and reversible.  The toxin presumably acts by blocking the channel pore in the open state.
What are the official names of this protein?
KappaPI-actitoxin-Ael3a, KappaPI-AITX-Ael3a, Kunitz-type serine protease inhibitor APEKTx1.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: KGUA_VIBVU
Sequence: MGKGTLYIVSAPSGAGKSSLISAMLEKNPTYAMKVSVSHTTRGMRPGEQDGVHYHFVEKEHFEDLITKGEFLEYAEVFGNYYGTSRVWIENTLDKGIDVFLDIDWQGARQIREQMPHAKSIFILPPSNGELERRLNTRGQDSEAVIAKRMAEAKSEISHYNEYDYVIINDDFDTALMDFKAIIRAERLKQDKQAAKYSGMLDALLAE
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.