PharMolix/UniProtQA huggingface dataset:
Protein: HSE1_CRYNJ
Sequence: MFSTAASPYDDLVIKATDENLASEDWALNMDVCDKVSSDGQNGARQAVTALQKRLSHRNPNVQIYALELANSLAQNCGKDLLGELSSRNWTSALDRLINDRATSTPVKKKALSFVKSWAKQIEETGDPNLGLMGELYDQLRAKNHVFDEPEPTPESAEEVRRRQEEEELQRVLELSKQDKGGRSLFTYQPSGSAGASSSSAANNNTSPSIPQSQAQPLAQDQAQSQAAPQVTGYAPQPQKIYSPQPLEPEPPRVDLNTATRVRAIYPFTGQEVGELDFERGDVIKVLDRGFKEWWRGACNGKIGIFPVTYVEALPEPTPKELQEKAQEEARVFASLGLVDQLLQTLKGIDPARGDKLDDHPEIEEMYQASVALQGQINTLIKKYSDQKAELEHMNANFIRAMGQYEELRNGPPLVQAQPFGYVPPQPQPLLQQQNSYSYQQYPQQPQQQPQPYAQAPYAQQAQPQLQPEQYAQQTPSPAAQSQASYTAQQQPYPAQVQQDPAAASPPPNQPFYHHGGSTTSVNRIPSAQTAVQPQPHGAPSFPPSSPPTRQVTEPGVAGLGAGDQQAWDQYYQQHGQQAPHSSQHPSQPQSQPQSQPQSQPQSQQGSYYPAHAQAQGYQAAYATVPDGRAYASPPLPGTQQGQGVEGVTAGMDRMSVHAP
What is the function of this protein?
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
What are the official names of this protein?
Class E vacuolar protein-sorting machinery protein HSE1.
What is the protein family that this protein belongs to?
Belongs to the STAM family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: COX2_DROPS
Sequence: MSTWANLGLQDSASPLMEQLIFFHDHALLILVMITVLVGYLMFMLFFNSYVNRFLLHGQLIEMIWTILPAIILLFIAMPSLRLLYLLDEINEPSITLKSIGHQWYWSYEYSDFNNVEFDSYMIPTNELSNDGFRLLDVDNRIVLPMNSQIRILVTAADVIHSWTVPALGVKVDGTPGRLNQTNFFINRPGLFYGQCSEICGANHSFMPIVIESVPVNYFIKWISNSVNS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GWT1_CANGA
Sequence: MSSLKERKEAFVSGLEGGSILEINVVTSIALTSYLCANLISYNDTQNIPLGIDFVLNWVAMLLSFTLYSQDIYLLTTLCLIPSIGWFLLNYKRNLKQSKNTVKHTTKEAVQKFELTKKPFLTAYRSGMLILTCLAILAVDFQIFPRRFAKVETWGTSLMDLGVGSFVFSNGIVSSRGLFREKMKDKKDKASSIKKIFAATRSGTTLLILGLSRLFFVKNLEYQEHVTEYGVHWNFFITLSLLPPVLVLIDPITSYIPQCILAMLFSTVYQLFLIKDDSLLTYLVLSDRNTFINANREGLISFVGYCSIFLWGQTIGFFILGNKKTTNNLYKCSVTVSRDKKNRTLWDRLTTVGPSLGLLIWFIITYALSEGLYLIHPQTVSRRFANMPYVLWVVCYNTAFLLCYSLVDKLFGNSSNFYRISTLLEAMNCNGLAMFLISNVSTGLVNMCIPTIDQNDKVSIVILLIYAAFLAMVSFSLYKHKIFIKL
What is the function of this protein?
Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.
What are the official names of this protein?
GPI-anchored wall transfer protein 1.
What is the protein family that this protein belongs to?
Belongs to the PIGW family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: KRFJ_CHICK
Sequence: MSCYSPCQTAACGPAPLANSCNEPCVLRCADSSVAIQPPPVVVTLPGPILSSFPQSTAVGSTASAAVGSSLSAGSVPIGAGGSLGLGGFGWSGLGRGLCGTLGRGNLLC
What are the official names of this protein?
Beta-keratin-related protein.
What is the protein family that this protein belongs to?
Belongs to the avian keratin family.
Protein: YBED_ECOLU
Sequence: MKTKLNELLEFPTPFTYKVMGQALPELVDQVVEVVQRHAPGDYTPTVKPSSKGNYHSVSITINATHIEQVETLYEELGKIDIVRMVL
What are the official names of this protein?
UPF0250 protein YbeD.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: ATG1_VANPO
Sequence: MIISGKYVIEKEIGKGSFATVLKGYIIDDNDNNGNDTNNEDVEVNDDKRKYTTRNQIAVKAVPRSKLKNKKLLENLEVEIAILKKIKHPHIVRLIECERTSTDFYLIMEYCALGDLTFLIKKRQEIMENHPLLKSVFKRFPPPSKNHNGLHRAFILNYLQQLSSSLKFLRSKNLVHRDIKPQNLLLATPFVDYHDSKSFHDLGYVGISSLPILKIADFGFARFLPNTSMAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLYEMCYGKPPFKASNHLELYKKIKKANNTISYSNDCEIEDDLKDLINALLTFDPNKRIGFQEFFDNKLVIEDLSKYEVANEVYSELELKSKSVLESNMFISEYLPSEKKKDDTDNMIISNLSTNDRINNITIFSNILPTVNENENDKTNDNSTTNYNNNDNENNDNNNTNHNYNNDKVNNKSNDNNEKSDINRSNSNYKQHSTKQTTNELIPNTNTITTNINDNSNSEMNSQSARMMQKSKNYKSLRNNKLRNSKNDIINNSNSDLILEKEYVVVEKKSVEVNTLADEMAQIGQINNLNYKVPYPSRSPTLAGNVLQNNESLQHYQPFSVKSPRTSLSSNGSGNSRRASLVDRRLSISSLNPSNALSRALGVASTKLFGSNVLPNQNAGVGNANNINTSMPLLNPQVFQDLTENILLRVDQLQGKDRINIDSNSIVQILESLAAKAFVVHSFAEVKFSQTIPLKSLSTSTVNRPANDRRLNDRGCAIEEDDNIQTETYDTYIPSLKGRSLSSLSQTSICSQDLPHGELYQLSKEAIILYMKTLSILATAMQITSNWWYQSNEKNCSLRLNLLVQWIRDKFNECLERADFLRIQILELEECENKSNELNSDHTDVETSGVNETVHNNDNDANEEDQIYVEKLLYDRALEISRTAAKLEIQGDHLNNCELAYATSLWMLEILLDDRIEDDNFNEFSSKNSAVLDDQDREIIKKYIDSIANRLKALREKISQGGS
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes.  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
What are the official names of this protein?
Serine/threonine-protein kinase atg1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: SHFL_BOVIN
Sequence: MSQEGVELEKSVRRLREKFHGKVSSKKAGTLMRKFGSDHTGVGRSIVYGVKQKDGQELSNDLDTQDPPEDMKQDRDIQAVATSLLPLTEDNLRMFQRAQEDLIPAVDRQFACSSCDHVWWRRVPQRKEVSRCRKCRKRYDPVPSDKMWGVAEFHCPKCRHNFRGWAQMGSRSPCYGCGFPVYPTRILPPRWDRDPDRRSTHTHSCSAEDCYNRREPHVPGTSCAHPKSRKQNHLPKVLHPSNLHISSGSTVATCLSQGGLLEDLDNLILEDLKEEEEEEEEEEEEGGHGE
What is the function of this protein?
Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes.  Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (By similarity).  May exhibit antiviral activity (By similarity).
What are the official names of this protein?
Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog, SHFL, Repressor of yield of DENV protein homolog, RyDEN.
What is the protein family that this protein belongs to?
Belongs to the SHFL family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly found in the cytoplasm.
Protein: SSB2_STRP8
Sequence: MINNVVLVGRMTKDAELRYTPSQVAVATFTLAVNRTFKSQNGEREADFINCVIWRQPAENLANWAKKGALIGITGRIQTRNYENQQGQRVYVTEVVADNFQMLESRATREGGSTGSFNGGFNNNTSSSNSYSAPAQQTPNFGRDDSPFGNSNPMDISDDDLPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein 2, SSB 2.
Protein: SYFB_SALTI
Sequence: MKFSELWLREWVNPAIDSDALANQITMAGLEVDGVEPVAGSFNGVVVGEVVECAQHPNADKLRVTKVNVGGERLLDIVCGAPNCRQGLKVAVATIGAILPGDFKIKAAKLRGEPSEGMLCSFSELGISDDHSGIIELPADAPLGTDIREYLKLDDNTIEISVTPNRADCLGIIGVARDVAVLNKAPLQEPEMAPVTATISDTLLITVEAVDACPRYLGRVVKGINVNAPTPLWMKEKLRRCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIDGGIVVRMAKEGETVVLLDGSEATLNADTLVIADHHKALGIAGIFGGEHSGVNGETQNVLLECAYFNPLSITGRARRHGLHTDASHRYERGVDPALQYKTIERATRLLLDICGGDAGPIIDVSNEATLPKRATITLRRSKLDRLIGHHIADEQVSDILRRLGCEVTEGQDEWKAVAPTWRFDMEIEEDLVEEVARVYGYNNIPDEPIQAGLIMGTHREADLSLKRVKTMLNDKGYQEVITYSFVDPKVQQLIHPGAEALLLPNPISVEMSAMRLSLWSGLLATVVYNQNRQQNRVRIFETGLRFVPDTQANLGIRQDLMLAGVICGNRYDEHWNLAKETVDFYDLKGDLEAVLDLTGKLGDIQFKAEMNPALHPGQSAAIYLKDERIGFIGVVHPELERKLDLNGRTLVFELEWNKLADRIVPQAREISRFPANRRDIAVVVAENVPAADILSECKKVGVNQVVGVNLFDVYRGKGVAEGYKSLAISLILQDTNRTLEEEEIAATVAKCVEALKERFQASLRD
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CR1HA_BACTU
Sequence: MEIINNQNQYVPYNCLSNPENEILDIESLSSRSREQVAEISLGLTRFLLESLLPGASFGFALFDIIWGVIGPDQWNLFLAQIEQLIDQRIEAHVRNQAISRLEGLGDSYEVYIESLREWEASPNNEALQQDVRNRFSNTDNALITAIPILREQGFEIPLLSVYVQAANLHLSLLRDAVYFGQRWGLDTVTVNNHYNRLINLINTYSDHCAQWFNRGLDNFGGVSARYLDFQREVTISVLDIVALFPNYDIRTYPISTQSQLTREIYTSPVAEPGASLNANLQNILREPHLMDFLTRLVIYTGVQSGIYHWAGHEISSRTTGNLSSNIQFPLYGTAASADRAFNMNIHHSETIYRTLSAPIYSVSGGISPNRTRVVEGVRFLIARDNNLDSLPFLYRKEGTLDSFTELPPEDESTPPYIGYSHRLCHARFARSPVILEPSNFARLPVFSWTHRSASPTNEVSPSRITQIPWVKAHTLASGASVIKGPGFTGGDIMTRNNINLGDLGTLRVTVTGRLPQSYYIRLRYASVANSSGVFRHLPQPSYGISFPRTMGTDEPLTSRSFALTTLFTPITLTRAQEEFNLTIPRGVYIDRIEFVPVDATFEAGYDLERAQKAVNALFTSTNQRGLKTDITDYHIDQVSNLVECLSDEFCLDEKRELSEKVKHAKRLSDGRNLLQDRNFISINGLLDRGWRGSTDITIQGSDDVFKENYVTLPGTFDECYPTYLYQKIDESKLKAYTRYQLRGYIEDSQDLEIYLIRYNAKHEIVNVPGTGSLWPLSVENSIGPCGESNRCAPHLEWNPNLDCSCRDGEKCAHHSHHFSLDIDVGCTDLNEDLGVWVIFKIKTQDGHARIGNLEFLEEKPLVGEALARVKRAEKKWRDKRKKLEFETNIVYKEAKESVDALFVNSQYDKLKADTNIAMIHAADKRVHRIREAYLPELSVIPGVNADIFEELEGRIFTAYSLYDARNVIKNGDFNNGLLCWNVKGHVDVEEQNNHRSVLVVPEWEAEVSQEVRVCPGRGYILRVTAYKEGYGEGCVTIHEIEDNTDELKFSNCVEEEVYPSNTVTCNDYTANQEEYEGTYTSRNQGYDEAYESNSSVPANYASVYEEKAYTDGRRENSCEFNRGYRDYTPLPAGYVTKELEYFPGTAKVWIEIGETEGTFIVDSVELLLMEE
What is the function of this protein?
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of insects.
What are the official names of this protein?
Pesticidal crystal protein Cry1Ha, 133 kDa crystal protein, Crystaline entomocidal protoxin, Insecticidal delta-endotoxin CryIH(a).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: FTZ_DROME
Sequence: MATTNSQSHYSYADNMNMYNMYHPHSLPPTYYDNSGSNAYYQNTSNYQGYYPQESYSESCYYYNNQEQVTTQTVPPVQPTTPPPKATKRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAPNGAGDFNWSHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDRTLDSSPEHCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAYPAYSHSHSHGYGLLNDYPQQQTHQQYDAYPQQYQHQCSYQQHPQDLYHLS
What is the function of this protein?
May play a role in determining neuronal identity, may be directly involved in specifying identity of individual neurons.  Required during embryogenesis for the process of body segmentation.  Homeotic protein, required in alternating segment primordia, it specifies the correct number of segments.
What are the official names of this protein?
Segmentation protein fushi tarazu.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
Protein: 5HT2A_MOUSE
Sequence: MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores.  Affects neural activity, perception, cognition and mood.  Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances.  Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
What are the official names of this protein?
5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Presynapse.
Protein: SELA_CAMJR
Sequence: MNKFRTFPQINTLIEDESLKSYPFYIKVFFCKKVVAKLKENFSQDEISKDKLLLEIKKEIKTFYRKDLQSVINASGVVIHTNLGRSVIHEELYEACKDIICNYSNVEFDLENGKRGSRYALVLEKLKMLFECEDALVVNNNAAAVFLVLNSLCYDKEVISSRGELVEIGGSFRVPEVIKAAGVKLCEVGTSNKTHLKDYEQAIGENTALILKTHKSNFALMGFHSEVNIKDLHELAKEKGLLSYYDLGSGWCENLNEKLIKNEPKIKKLVQECDILSFSGDKLFGSAQAGIILGKKELIEKLKQNQLLRMLRVDKLTLSFLNESLKAYLQKDYKKIITLKLLNDDLSFIEKKALRVQKELNFQTQLKKSKSLVGGGSMPDKSLDTYILTFQGDALKLQTRFRKENIIGRIENDEFVLDFRTIRENELQKLILTINQMENL
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_AZOSB
Sequence: MNKKETRLRRARKTRAKLAELKAVRLAVFRTNCHIYAQVISGCGSRVLAAASTVESAVRSQVANGGNKQAAEVVGKLIAERAKAAGIETVAFDRSGFLYHGRVKALAEAAREGGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ZAP70_MOUSE
Sequence: MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCQFYSQDPDGLPCNLRKPCNRPPGLEPQPGVFDCLRDAMVRDYVRQTWKLEGDALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGQQTDGKFLLRPRKEQGTYALSLVYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYRLKEVCPNSSASAAVAAPTLPAHPSTFTQPQRRVDTLNSDGYTPEPARLASSTDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLLGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRMRNYYYSLASRAEGPPQCEQVAEAACG
What is the function of this protein?
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response.  Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development.  Contributes also to the development and activation of primary B-lymphocytes.  When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD3Z through ITAM motif at the plasma membrane.  This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation.  Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK.  Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2.  In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.  Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC.  ZAP70 is also required for TCR-CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2.  Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface.  During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative).  Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR).
What are the official names of this protein?
Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In quiescent T-lymphocytes, ZAP70 is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes.
Protein: MNMA_MYCS2
Sequence: MRVLVAMSGGVDSSVAAARMVDAGHDVVGVHLALSSAPGTLRTGSRGCCSKEDASDARRVADILGIPFYVWDFADRFKDDVIDDFVESYARGETPNPCVRCNERIKFSALAARALALGFDAVATGHYARLSDGRLRRAVDADKDQSYVLGVLTAEQLRHALFPIGDTPKPQIRAEAAERGLAVAEKPDSHDICFIPTGDTKAFLGARIGVRPGAVVDGSGTVLAEHDGVHGFTIGQRKGLGIAGPGADGRPRYVTAIDAETGTVRVGPAEDLEVWELTGERPVFTSGVEPGGPIECQVQVRAHGGITDTVAELRDGKLELSLRAPLRGVAPGQTMVLYRPDPDGDEVIASATITRR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXX01_LYCSI
Sequence: MKLSLIIIATSLVIAVVAFPSKDSAATDFDKTESLENVEERVETALDERPRACSKNPGESCTNNCECCGATVVCASVYVAGVEKKSCKSKTSDNGFLNIIGQAANAVQNAASLCV
What are the official names of this protein?
Toxin-like structure LSTX-R1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 25 family. F7 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRM56_METMP
Sequence: MAIEILRLGHRGERDKRISTHVALTSRALGAEKIIFTEEDKHVKESVERIVEAWGGEFKFEVVKSWRSYAKRFKDNGIVVHLTMYGENINKIMTEIREDISKTNKNLLLIIGAEKVPREAYDLADYNLSVGNQPHSEVAALAIFLDRFTEGKTLYSEYDDAKIKVTPSKSEKCVFVEKD
What is the function of this protein?
Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
What are the official names of this protein?
tRNA (cytidine(56)-2'-O)-methyltransferase, tRNA ribose 2'-O-methyltransferase aTrm56.
What is the protein family that this protein belongs to?
Belongs to the aTrm56 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIB1_ARATH
Sequence: MTHKKQKKEMSDSEKKTFNEDSKHSILAVDLVRLILERLSFVDFHRARCVSSIWYIASKTVIGVTNPTTPWLILFPKGDVEIKKDSCKLYDPHENKTYIVRDLGFDLVTSRCLASSGSWFLMLDHRTEFHLLNLFTRVRIPLPSLESTRGSDIKIGNAVLWVDEQRKDYLVVWNISSLFGYHKKGDDRWKVFKPLENERCIIAMVFKENKLYVLSVDGNVDVFYFSGNDSPVRCATLPSSPLRKGHKVVVTLSGEVLIIVAKVEPYPRTRLCFFAVYKMDPKSSRWETIKSLAGEALILDLGITVEAKVMKNCIYFSNDQFHRYNENSLWNVSNKSGVFVYHFRSANVVQLVELLTASSRTSKILFKDARCFFPTFTSKWLL
What is the function of this protein?
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.  Required for brassinosteroid (BR) signal transduction.  Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e. g.  BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation.
What are the official names of this protein?
F-box/kelch-repeat protein KIB1, Protein KINK SUPPRESSED IN BZR1-1D 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Mostly localized in the nucleolus, and, to a lower extent, in the cytoplasm.
Protein: IND10_ECOLI
Sequence: MWTGKKVDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI
What is the function of this protein?
Involved in the transposition of the insertion sequence IS2.
What are the official names of this protein?
Transposase InsD for insertion element IS2-10.
Protein: RL9_MOOTA
Sequence: MKVILTADVAKLGNRGTLVEVSEGYARNYLLPRGLAVEATAGRLKELDLEKKRREKKENQELENARRQAARLDGAVVKITTRAGETGKLFGSVTNKEIAEAIKNTFQISLDRRKIDLKEPIKALGSYEVTLKLHPTVQAHLRVQVVAEGS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ATPB_CHAVU
Sequence: MTTVNLDLQNSLVAEKNRGKITQIIGPVMDISFLPGQMPNIYNCLTVKGKNASGDFIDVTCEVQQLLGDNKVRAVAMSATDGLMRGMEVIDTGSPLSVPVGETTLGRIFNVLGEPVDNLGPVDTSITFPIHRAAPAFTQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESKVINEENISESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGTLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRNLAAKGIYPAVDPLDSTSTMLQPWIVGEEHYETAQGVKETLQRYKELQDIIAILGLDELSEEDRLIVARARKIERFLSQPFFVAEVFTGSPGKYVSLIDTIKGFQMILSGELDHLPEQAFYLVGDIEEATAKAATIQVQSE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.