PharMolix/UniProtQA huggingface dataset:
Protein: PIGX_RAT
Sequence: MAASALAWLLLWAAGLVGRLAADISDARFSDGVRATCSEIILRQEFLKDGFHRDLLIKVKFGESIEDLQTCRLLIKHYIPTGLFVDPYELASLRERNITEAVMVSESFNLEAPNYLSTESAVLIYARQDAQCIDCFQAFLPVHYRYHRPHKKDGDTLIVVNNPDLLMHCDQEFPILKCWAQSEVAAPCSLKSEEICQWKNMQYKSILKNLTVQVPVGLTIHTSLVCSVTLLITVLCSTLILLAVFKYGHFSL
What is the function of this protein?
Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis.  Probably acts by stabilizing the mannosyltransferase PIGM.
What are the official names of this protein?
Phosphatidylinositol-glycan biosynthesis class X protein, PIG-X.
What is the protein family that this protein belongs to?
Belongs to the PIGX family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: GLIS2_HUMAN
Sequence: MHSLDEPLDLKLSITKLRAAREKRERTLGVVRPRALHRELGLVDDSPTPGSPGSPPSGFLLNSKFPEKVEGRFSAAPLVDLSLSPPSGLDSPNGSSSLSPERQGNGDLPPVPSASDFQPLRYLDGVPSSFQFFLPLGSGGALHLPASSFLTPPKDKCLSPDLPLPKQLVCRWAKCNQLFELLQDLVDHVNDYHVKPEKDAGYCCHWEGCARHGRGFNARYKMLIHIRTHTNEKPHRCPTCSKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKAHGHFVSHEQQELLQLRPPPKPPLPAPDGGPYVSGAQIIIPNPAALFGGPGLPGLPLPLAPGPLDLSALACGNGGGSGGGGGMGPGLPGPVLPLNLAKNPLLPSPFGAGGLGLPVVSLLAGAAGGKAEGEKGRGSVPTRALGMEGHKTPLERTESSCSRPSPDGLPLLPGTVLDLSTGVNSAASSPEALAPGWVVIPPGSVLLKPAVVN
What is the function of this protein?
Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context.  Acts as a repressor of the Hedgehog signaling pathway (By similarity).  Represses the Hedgehog-dependent expression of Wnt4 (By similarity).  Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity).  Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway.  May act by recruiting the corepressors CTBP1 and HDAC3.  May be involved in neuron differentiation (By similarity).
What are the official names of this protein?
Zinc finger protein GLIS2, GLI-similar 2, Neuronal Krueppel-like protein.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm.
Protein: Y112_NPVAC
Sequence: MTKRQFALLFVWHHDNQFVCNTDEYPFWHNIEYHARRYKCIVLYCVENDGSLQLPVCKNINLINYKKAYPHYYGNCVDSIVKRAGKN
What are the official names of this protein?
Uncharacterized 10.5 kDa protein in HE65-PK2 intergenic region.
Protein: PPAC_PIG
Sequence: MAEQVTKSVLFVCLGNICRSPIAEAVFRKLVTDQNVSDNWVIDSSAVSDWNVGRSPDPRAVSCLRHHGINTAHKARQITKEDFATFDYILCMDESNLRDLNRKGNQVKNCRAKIELLGSYDPQKQLIIEDPYYGNDSDFEAVYQQCVRCCRAFLEKVR
What is the function of this protein?
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.
What are the official names of this protein?
Low molecular weight phosphotyrosine protein phosphatase, LMW-PTP, LMW-PTPase, Low molecular weight cytosolic acid phosphatase.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPC1L_HUMAN
Sequence: MARMAVLWRKMRDNFQSKEFREYVSSTHFWGPAFSWGLPLAAFKDMKASPEIISGRMTTALILYSAIFMRFAYRVQPRNLLLMACHCTNVMAQSVQASRYLLYYYGGGGAEAKARDPPATAAAATSPGSQPPKQAS
What is the function of this protein?
Mediates the uptake of pyruvate into mitochondria.
What are the official names of this protein?
Mitochondrial pyruvate carrier 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PROFE_OLEEU
Sequence: MLWQAYVDDHLMCDIEGHEGHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVFGIYEEPVTPGQCNMVVERLGDYLLEQGL
What are the official names of this protein?
Profilin-2, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: YPE4_LACLC
Sequence: MSQNTKGKLSLVGLSLMI
What are the official names of this protein?
Uncharacterized protein in pepT 3'region, ORF4.
Protein: SCO1_BOVIN
Sequence: MAGLLLAPGRIMRLPGSQLWRLFPRGFGVWGPGKETASVLLGRLCARPEEAWRASGLAACCLGSRPLSTAMPPPPGSSGPEWKGSGDPMRPSKPGPVSWKSLAVTFAIGGALLAGMKYFKKEKTEKLEKERHRSIGKPLLGGPFSLTTHTGEPKTDKDYLGQWVLIYFGFTHCPDICPEELEKMIQVVDEIDSIPTLPNLTPLFITIDPERDTKEAIANYVKEFSPKLIGLTGTKEEIDQVARAFRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKKNAEIAGSIAAHMRTHRKKS
What is the function of this protein?
Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2).  Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation.  Involved in transporting copper to the Cu(A) site on MT-CO2/COX2.  Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1.
What are the official names of this protein?
Protein SCO1 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the SCO1/2 family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane; Single- pass membrane protein.
Protein: PCEP8_ARATH
Sequence: MAKALFFNFCISLLIIAILVSHEIIPTEARHLRTHRKSIKNSTLTVHEGAGGLRTGGGSVKTDISKEEHGVDEFRPTTPGNSPGIGH
What is the function of this protein?
Extracellular signaling peptide that may regulate primary root growth rate and systemic nitrogen (N)-demand signaling (By similarity).  Mediates up-regulation of genes involved in N uptake and assimilation pathways (PubMed:25324386).
What are the official names of this protein?
Precursor of CEP8, PCEP8.
What is the protein family that this protein belongs to?
Belongs to the C-terminally encoded plant signaling peptide (CEP) family.
What are the subcellular locations of this protein?
[C-terminally encoded peptide 8]: Secreted, extracellular space, apoplast. Note=Accumulates in xylem sap.
Protein: IPK2_CENMR
Sequence: AEDCVGRKACTREWYPVCGSDGVTYSNPCNFSAQQEQCDPNITIAHMGEC
What is the function of this protein?
Serine protease inhibitor.  Strongly inhibits human neutrophil elastase and trypsin, also inhibits porcine pancreatic elastase and subtilisin A.  Does not inhibit chymotrypsin, plasma kallikrein, pancreatic kallikrein, thrombin or papain.
What are the official names of this protein?
Protease inhibitor 2, CmPI-II, Protease inhibitor-II.
Protein: OR4KF_HUMAN
Sequence: MNETNHSRVTEFVLLGLSSSRELQPFLFLTFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDVCVASFATPKMIADFLVERKTISFDACLAQIFFVHLFTGSEMVLLVSMAYDRYVAICKPLHYMTVMSRRVCVVLVLISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACIDTYVVSLLIVADSGFLSLSSFLLLVVSYTVILVTVRNRSSASMAKARSTLTAHITVVTLFFGPCIFIYVWPFSSYSVDKVLAVFYTIFTLILNPVIYTLRNKEVKAAMSKLKSRYLKPSQVSVVIRNVLFLETK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 4K15, Olfactory receptor OR14-20.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NRP32_POPTR
Sequence: MPVEENYQPLLQEEEERAYDSDEKVLIIGVDSDTESGGSTVLPPFSWKKLWLFTGPGFLMSIAFLDPGNLEGDLQAGAIAGYSLLWLLLWATAMGLLVQLLSARLGVATGRHLAELCREEYPTWASMVLWIMAELALIGADIQEVIGSAIAIKILSNGFVPLWAGVTITACDCFIFLFLENYGVRKLEAVFAVLIGIMAVTFGWMFADAKPSASELFLGILIPKLSSRTIQQAVGVVGCIIMPHNVFLHSALVQSREIDHNKKDRVQEALRYYSIESTTALVISFVINLFVTTVFAKGFYGTELANSIGLVNAGQYLQDKYGGGFFPILYIWGIGLLAAGQSSTITGTYAGQFIMGGFLNLRLKKWLRALITRSCAIIPTMIVALVFDTSEDSLDVLNEWLNVLQSIQIPFALIPLLCLVSKEQIMGTFKIGPILKMVAWLVAALVMVINGYLLLDFFFNEVTGVAFTTVVCGFTGAYVAFIIYLISRGFTCFSRCCPSKQIEVE
What is the function of this protein?
Divalent metal transporter (PubMed:35700212).  Can transport manganese (Mn) and iron (Fe) (PubMed:35700212).  Involved in the release of metals stored in the vacuole (PubMed:35700212).
What are the official names of this protein?
Metal transporter Nramp3.2, PotriNRAMP3.2, PtNRAMP3.2, Natural resistance-associated macrophage protein 3.2.
What is the protein family that this protein belongs to?
Belongs to the NRAMP (TC 2.A.55) family.
Protein: MEND_GRAFK
Sequence: MKYSKIPVARSVVALCVAKDIKHVVISPGSRNAPLTIGFTHHDEITPYSIVDERCAAFFALGLAQELKKPVALVCTSGSALLNYYPAIAEAYYSDIPLVIISADRPIERIDIGDGQTIRQKNVFENHILYSANLYSELVLENQSQDPKLQQKQFEAQKHNEREVNLALNKAIEEKGPVHINVPFYEPLYDTVENINVNPLQIFPEIKERHYSEKQLQNYANEWNRAERKMVIVGVAQPNAVEQKFLEGLATDPSVIVLTETTSNLHQEQFFTRIDTLIGPIEKDENREELFNRLQPDILLTFGGMIVSKKIKSFLRNYSPQHHWHIDSKKAYNTFFCLNKHFETDVNSFFSEFFPLTKRTESDYGSFWKDIKGKRQHRHEDYMAEIPYSDLKAMQEIYQKIPKNSVLHFGNSSTIRYAQLFEWDKSLKIYCNRGTSGIDGSVSTAVGASVSSEEPVTIITGDLSFFYDSNALWNNYIPSNFRIIILNNNGGGIFRILPGNKNSENFEKYFETTHNLKAKPICDLYNFDYEKANSEEEIQKVMKDFYSESGKPKLLEIFTPRKINDEVLLEYFNFMKS
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: UVRC_RICBR
Sequence: MTMELTGNELIKSKLIDIPERSGVYRMFDANKQVIYVGKAKNLKKRLTNYIKTDLDTKTLRMVANTCSLEYSITNSEVEALLLEAQLIKKFQPKFNILLKDDKSFPFIKLRLDHDFPQLLKYRGRALNDGKFFGPFASATEVNTTLSELQKIFKLRSCTDNYFNSRTRPCLQYEIKRCYAPCVGKINKKDYAELVGQVKDFLQGRSKELQENLSKKMEELSEQMRFEEAAEIRDRIKALSYVQLKAGITDIVKDADIIAIVEKNGHYCVEVFLYRIGQACGNIPYFPTSTENSTKEEVLKHFLLQFYQKQQVPPGIIINHEIDDKDNIIEAIRNINDFAKLSITIPASGGKLKLVQNAQENALFSLEQYLKKFAKNQELMFEVKELFNLPEIPERIEVYDNSHIQGKFAVGVMIVAGKSGFDKKEYRVFSLSSRDSITGSSKSTNNDSISCFLDTVDKPRYDTKGDDYEMLRQVLTRRLTRLKQEPHRLPSLMIIDGGKGHLGIVKEVMNKLQMDIPFVCMSKGPDRNAGLEQFHMVGREVFTLNKNLPLMKYLQILRDEAHNFAIKNHRLSRSRAIKVSSLDEIEGIGDTRKKALLHYFGSYKAVSDATLDELSKVKGISKSLAKMIFNALHKN
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANIA_NEIGO
Sequence: MKRQALAAMIASLFALAACGGEQAAQAPAETPAASAEAASSAAQATAETPAGELPVIDAVTTHAPEVPPAIDRDYPAKVRVKMETVEKTMKMDDGVEYRYWTFDGDVPGRMIRVREGDTVEVEFSNNPSSTVPHNVDFHAATGQGGGAAATFTAPGRTSTFSFKALQPGLYIYHCAVAPVGMHIANGMYGLILVEPKEGLPKVDKEFYIVQGDFYTKGKKGAQGLQPFDMDKAVAEQPEYVVFNGHVGSIAGDNALKAKAGETVRMYVGNGGPNLVSSFHVIGEIFDKVYVEGGKLINENVQSTIVPAGGSAIVEFKVDIPGSYTLVDHSIFRAFNKGALGQLKVEGAENPEIMTQKLSDTAYAGSGAASAPAASAPAASAPAASASEKSVY
What is the function of this protein?
Catalyzes the reduction of nitrite to nitric oxide (NO), probably with azurin as electron donor.  Essential for growth and survival in oxygen-depleted environments.  Can also provide protection against killing by normal human sera.
What are the official names of this protein?
Copper-containing nitrite reductase, Major outer membrane protein Pan 1.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: FADA_CITK8
Sequence: MEQVVIVDAIRTPMGRSKGGAFRNVRAEDLSAHLMRSLLARNPALEATAIDDIYWGCVQQTLEQGFNIARNAALLAEIPHSVPAVTVNRLCGSSMQALHDAARMIMTGDAQTCLIGGVEHMGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLSRMHGISREMQDAFAARSHARAWAATQSGAFKNEIIPTGGHDADGVLKQFSYDEVIRPETTVEALSTLRPAFDPVSGTVTAGTSSALSDGAAAMLVMSESRARELGLQPRARIRSMAVVGCDPSIMGYGPVPASKLALKKAGLAASDIDLFEMNEAFAAQILPCIKDLGLMEQIDEKINLNGGAIALGHPLGCSGARISTTLLNLMERKDAQFGLATMCIGLGQGIATVFERVQS
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_SHEB2
Sequence: MSGNSIGQNFVVTTFGESHGVALGCIIDGCPPGLELTEADMQHDLDRRRPGTSRYTTARREPDEVRILSGVFEGKTTGTSIGLLIENTDQRSQDYSNIKDLFRPGHADYTYQQKYGMRDYRGGGRSSARETAMRVAAGAVAKKYLKQVHGIEIYGFMSQLGPICAETIDLDQIEQNAFFFPDASKLEALDEYMRELKKSGDSIGAKISVIATGVPVGLGEPVFDRLDADIAHALMGINAVKGVEIGDGFGVVTQKGSEGRDLMSPQGFESNHAGGVLGGISSGQPIIAHIALKPTSSISVPGQSMTAQGEMAEVVTKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRHRAQNQDVRSHTPVLGMR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: SYI_RALPJ
Sequence: MSDSKKPTPEKSKYPVNLLDTPFPMRGDLPKREPLWVKQWQDKQLYKKIRAARKGAKKFILHDGPPYANGDLHIGHAVNKILKDMVIKARGLTGLDAVYVPGWDCHGMPIEIQIEKQFGKGLPVKEVQEKARAYATGQIARQKADFERLGVLGDWADPYLTMNFRNEADEVRALGKILEKGYVFRGLKPVNWCFDCGSALAEAEVEYADRTDLSIDVGFPFADIDALASAFHVGADVLKAKPGWIVIWTTTPWTIPSNQALNLHPEIEYALVDTSRGLLIVAKERVEACLQSWKLEGTVLATCEGAALNGVRFHHPLAKMDAGYDRTSPVYLGDYVTIDTGTGIVHSAPAYGVEDFQSCKAHNMPDSEIINPVMGNGVYASTLPLFGGQMIWDANPKIVEVLRESGNLFDAHKYAHSYMHCWRHKTPIIYRATSQWFAGMDVQPNDGNATLRETALAGIDATAFYPSWGKQRLHNMIANRPDWTLSRQRQWGVPMAFFVHKETGALHPRTPELLEQVAQRIEKSGIEAWQTLDPRELLGDEADMYEKNRDTLDVWFDSGTTHWHVIRGSHAADLYDASADLPDGRLADLYLEGSDQHRGWFHSSLLTASMLYGKPPYKGLLTHGFTVDGEGRKMSKSIGNTIAPQEIANKMGAEIIRLWVASTDYSGELAISDEILKRVVEGYRRIRNTLRFLLANLTDYDHAKHALPTEQWLEIDRYAVALTDALQKEVLSHYDVYEFHPVVAKLQTFCSEDLGGFYLDVLKDRLYTTAPDSVARRSAQNALYHITQAMLHWMAPFLSFTAEEAWQVFAHGTEHTDTIFTSTYYNAPVPQGASALLEKWAAIRNVRGEVTKQLEALRIDGKIGSSLQAEVTVSAGESVHDALASLGDDLRFVLITSAAKLERAPEGGDLLITVVPSTHSKCERCWHYRADVGHDHAHPTLCKRCTDNLFGSGEQRSAA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T4BA_WEICA
Sequence: MVNEKTSTDQLVRRFIEDLGVTYEEQGSSNIQIKQALRSASKSKSQSGVGKPEFIFFSGNHLIIVEDKLAIDKLEYKNNDGIIDTEFPFRRDYAVNGAVHYARHIIEKTNSYKEVIAIGIAGDGLHYQIHPYFVSETELKKLPEMKSLEDISPENIEEFYKVAVLGELPKEERELREVNKIAADMHEDLRNYGQLEGEKKATVVSAILLALEEPTFSLNQLIGSDRVGGTDGEIIFNAVRVYLENAGIVPYAKVGEMLDQFIFIQRDVTLNTVNSNLEMTPLKYFATTLEAEIMDKIKSNTDFDILGNFYGEFVKYGGNDGNPLGIVLTPRHITSLMAELIGINKSDFVLDPACGTGAFLISAMNRMLGQAENDDERRDIKQNRLYGIEIQQKLFTIATTNMILRGDGKSNLIRDNCLTFDNTIMNGYGINKILMNPPYSQAKNDQTQHLSELSFIQQALEMLVVGGKLCAIVPQSTMVGKNRHDKARKKQILKQHTLETVITLNKDTFHGVGVNPCIVIFKAGIKHPENKRVSFVNFEDDGHVVRKHVGLVGDGTEKGKREHLLAVLAGDEDDGTDLIVKTAIKDTDEWLHSFYYFNDGIPSEDDFYKTVANYLTFQFDMTANGKGYLFEGVEENE
What is the function of this protein?
A B, G, H and S subtype restriction enzyme that recognizes the double-stranded sequence 5'-CGAN(6)TGC-3' and cleaves bilaterally and symmetrically 10 base pairs upstream and 12 base pairs downstream of the sequence to release a 34-base pair fragment.  Methylation of the recognition sequence occurs on the adenine in either one or both strands; seems to methylate restricted DNA (PubMed:8451198, PubMed:8276869, PubMed:12654995).  This subunit has no methylation or DNA restriction activity on its own (PubMed:8276869).
What are the official names of this protein?
Type II restriction enzyme and methyltransferase RM.BcgI, Restriction enzyme BgcI subunit A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the N(4)/N(6)-methyltransferase family.
Protein: ARGB_CHRSD
Sequence: MSENARDPRLVVEILSEALPYIQRFSGKTVVVKYGGNAMTEDTLIDSFARDMVLMKEVGINPVVVHGGGPQIGELLERLNIESRFVGGMRVTDAETMDVVEMVLGGLVNKSIVNLINRSGGKAIGLTGKDGAQITARQLRVEHQTPEMTAPEIIDIGHVGEVEHIATDLIEMLAARDFIPVIAPIGVDAEGHSYNINADLVAGKVAEALGAEKLMLLTNVAGLMNAEGEVMTGLSTAQVDAMIGDGTIHGGMLPKIRCALEAVKGGVASSHIIDGRVPHATLLEIFTNAGVGTLITDTASDVSPED
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU1_PHOLL
Sequence: MSKEKFERKKPHVNVGTIGHVDHGKTTLTAAITTVLAKTFGGNARAFDQIDNAPEEKARGITISTSHVEYDTPSRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPVIRGSALKALEGDAEWEAKIIELAEALDSYIPEPERAIDQPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKDTTKTTCTGVEMFRKLLDEGRAGENVGVLLRGTKRDEIERGQVLAKPGSIKPHTTFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIQMKVTLIAPIAMDQGLRFAIREGGRTVGAGVVAKVIA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 1, EF-Tu 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUS_MPV15
Sequence: MIPGRIFLVLLVIFNTKPIHPNTLTEKYYESTCSVETAGYKSALRTGWHMTVMSIKLSQINIESCKSSNSLLAHELAIYSSAVDELRTLSSNALKSKRKKRFLGLILGLGAAVTAGVALAKTVQLESEIALIRDAVRNTNEAVVSLTNGMSVLAKVVDDLKNFISKELLPKINRVSCDVHDITAVIRFQQLNKRLLEVSREFSSNAGLTHTVSSFMLTDRELTSIVGGMAVSAGQKEIMLSSKAIMRRNGLAILSSVNADTLVYVIQLPLFGVMDTDCWVIRSSIDCHNIADKYACLARADNGWYCHNAGSLSYFPSPTDCEIHNGYAFCDTLKSLTVPVTSRECNSNMYTTNYDCKISTSKTYVSTAVLTTMGCLVSCYGHNSCTVINNDKGIIRTLPDGCHYISNKGVDRVQVGNTVYYLSKEVGKSIVVRGEPLVLKYDPLSFPDDKFDVAIRDVEHSINQTRTFFKASDQLLDLSENRENKNLNKSYILTTLLFVVMLIIIMAVIGFILYKVLKMIRDNKLKSKSTPGLTVLS
What is the function of this protein?
Major determinant of the species specificity of RSV infection.  The trimer of F1-F2 (F protein) also facilitates the attachment and entry into the host cell.  Later in infection, F protein expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.
What are the official names of this protein?
Fusion glycoprotein F0.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
[Fusion glycoprotein F0]: Host Golgi apparatus membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: [Fusion glycoprotein F1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein. Note=Localized at the host apical membrane. SUBCELLULAR LOCATION: [Fusion glycoprotein F2]: Virion membrane. Host cell membrane. Note=Localized at the host apical membrane.
Protein: GUAA_MYCTA
Sequence: MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLERISTRITNEVAEVNRVVLDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RIHB_ESCF3
Sequence: MEKRKIILDCDPGHDDAIAIMMAAKHPAIDLLGITIVAGNQTLDKTLINGLNVCQKLEINVPVYAGMPQPIMRQQIVADNIHGETGLDGPVFEPLTRQAENTHAVKYIIDTLMASDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGNFTPSAEFNIFADPEAARVVFTSGVPLVMMGLDLTNQTVCTPDVIARMERAGGPAGELFSDIMNFTLKTQFENYGLAGGPVHDATCIGYLINPDGIKTQEMYVEVDVNSGPCYGRTVCDELGVLGKPANTKVGITIDTDWFWGLVEECVRGYIKTH
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.  Has a clear preference for cytidine over uridine.  Strictly specific for ribonucleosides.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihB, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihB subfamily.
Protein: LGT_MAGSA
Sequence: MTFALAYPHIDPIALQIGPIAIRWYALAYIAGLMLGWRYVKFLVARPPNAMTELEVDDFLVWATMGVVLGGRLGYVLFYKPLYYLENPLEIPMVWQGGMSFHGGALGVIVGIIAFSRFRGRNLFQVGDVICCAVPIGLFFGRIANFVNGELFGRVAPDVDWAMVFPGGGPLPRHPSQLYEAGLEGAVLFLVLFGLWRLTGIRHRAGALSGVFLAGYGLARIASEFFRQPDAHLGFLWGGATMGQLLSIPQVLVGLALLAWALRRGAKAA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSBRC_BACSU
Sequence: MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIHNLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRDLYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDMITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVIDTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASDLKLKKV
What is the function of this protein?
Negative regulator of sigma-B activity.  Non-phosphorylated RsbS binds to RsbT, preventing its association with RsbU.  Requires any one of RsbRA, RsbRB, RsbRC or RsbRD to sequester RsbT.  When RsbS and the RsbR paralog(s) are phosphorylated, they release RsbT, which can then bind and activate RsbU.
What are the official names of this protein?
RsbT co-antagonist protein RsbRC, Stressosome protein RsbRC.