PharMolix/UniProtQA huggingface dataset:
Protein: MUTL_CLOBL
Sequence: MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSKINSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKFLKSARSDSSSISDIVNRFILAHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKPEISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFDAVHGAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLSNNTELLKNIGIKEKNTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDTLYLNEHNTNSSSINIKENKPNNFYVDMKIIGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIENRYVISQILLSPVVIELSEDEFNIYEENKDIFKNSGFSVETFGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETSTIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNPYTCPHGRPTMIKFTLKDLEKKFKRIQ
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: GP146_HUMAN
Sequence: MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCYNALLVLANLHSKASMTMPDVYFVNMAVAGLVLSALAPVHLLGPPSSRWALWSVGGEVHVALQIPFNVSSLVAMYSTALLSLDHYIERALPRTYMASVYNTRHVCGFVWGGALLTSFSSLLFYICSHVSTRALECAKMQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDTPLDRDTGRLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMNQSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 146, G-protein coupled receptor PGR8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EXO5_DANRE
Sequence: MMDASRSQQPLDAWDDISDSEFLNIPSDEESIESQLPLIGETKGKHSVNLDKPSSSSSFHKCSEEAPKQEAVKTDDVRGLKRKSLHENSFSPMQRFRKQHLSVTLLCDQTWCEMKSVYNLLKPHIKRKEMQRTEVQIGQEIHLSRELEIQDVVPVDIRTREDGEAVKLLNMLHMIPLLEAGQRVREFPVFGVQEGVFIMGVIDELMYNQKGELVLNELKTRRQNSLPSSAQDKVNCFQVGLYKLLFDGLVRGEMKKNHIFDHLKLRSAQILGAGVQAHAKNLGVHARTFEELVETLLITVSCSDLPCIDLLQIEYFHQGSNGPIGTRVAPFDEAQIRGELQAYLSYWTGQREPKGVDIEEAWKCRSCLYEEICEWRKNRFTVSDQQAAHSSSHL
What is the function of this protein?
Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair.  Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage.  Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends (By similarity).
What are the official names of this protein?
Exonuclease V, Exo V.
What is the protein family that this protein belongs to?
Belongs to the EXO5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: CH10_STRR6
Sequence: MLKPLGDRVLLKIEEKEQTVGGFVLAGSAQEKTKTAQVVATGQGVRTLNGDLVAPSVKTGDRVLVEAHAGLDVKDGDEKYIIVGEANILAIIEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABCG5_DICDI
Sequence: MVKQDPRDKSSYSPNLSIPINNQEEPTLNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNNNNNIKHKDEENDFEDSIYQIAKEHEGEEDDEYFPIPLDELMPNHENDELTKKIKQTRPEDKTGLYVYCRNATYTVKHRENKKVKIKLLDDVSFFLRPKQMTLILGTPGCGKSTIFQMLAGQLKDKHFEGELLFNGHPINHKNHHRDISYVTQDDIHVPTLTVKETFRFALDCLGKKELTREEKQVSVDNCMKLLGLKHAENTLVGDNFIRGISGGQKKRVTIGVGVIKGSNLLLMDEPTSGLDSSTSFEILSDVKKFVTYGYSPALITLLQPSVQLTSLFDNLMIMSKGKICYFGPMNRALGYFKKLGFACPSHNNPAEFFQEVVDAPERYSFIHPPKCKTSDDFVKAYRESDIYLELMEKMDANKDGIVDDNKPKVLVDSTAKELGMYPHGIGYQTKICLKRGFIMISRNYYNFATRVFKGIFFGLLLGTLYWRIGHNQSGGMERFGLLFFIMTTIIFSSFAAVNSFFGERKVFYSQKALHYYKTGAYFISSIICDIPAGLIEVAFFGPIVYWLANLRPVFIRFVYFMILLFITDNLSLSFAKMCAAISPTIEIANVTASVILSIWLLFSGFTAPKNDIGGWWIWLYYISPYTWIFQGLSINEFTYQAYGCKDSELIPPRTPQNLLPYPEGFGGNQVCQYTSGEQIMDAFGINNPDYFKWIVYAILGAYIVFFYSVCFFALKYLNFEDKKSKLAVKKLKKKKKVIVCKEDEEPNCKVTTEALERVSDDNDDNADISNYDDDTVIDMKSPLTSPNYNNNNNLSGSGNNIKRRKVKTPSTLSPMVNSPLTNLSPMVNTPSKNGNHSKQKPISTSQKDISSETGSYLQFKKLCYAVDVKADDPDNPKKKKSQRLQLLTDIDGYVKPGQMLALMGPSGAGKSTLLDVLAQRKTGGHITGEILINGKPPSEFTNRIRAYVEQMDVLPPTQTVREAIAFSARCRLPPEVTKEEREIFVDKIVEVLSLSSIKDLKIGVLGNGLSVSQRKRVNIGVELASNPEILFLDEPTSGLDSGDAFKVIDVVNKIAKVMNRTVICTVHQPSAAIFEFFDQLLLLKKGGETIYFGPLGNQSSVILDYCDKLGMHIKPHINPADFVMTLADEGKMVEGPNGEQEHLDAKKAYFESNICKKEYEIMEGQLIPDDFVVKTYDSRFASSWMTQFRALCMRSWLSRLRRPAIFVSNCLRSILLAVLLGTLFVRMDYEQKDARSRVSLLFFSFLFAGMVAIGNIPTTVLERGVFYREVTAGFYHSTAYMISYVLTSYPFILSTGILYIIPTFWIAGLDSGRHSSKFWYCLFIFIITYIMYDAFALCLAVCLPNEVMASTICGIGLSLATLFGGFVIARPNYPSAYYWCHYLDWLRYPLEASCTNEFTGLTFVCTNNKGAVPIPIIENGVQIAIKYYCPITNGDDFMLTYGFHKFMRYIDIAAIFGYIFIFVGLSFWGFKKVRWLNR
What are the official names of this protein?
ABC transporter G family member 5, ABC transporter ABCG.5.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GLPK_CERS4
Sequence: MNHILAIDQGTTSSRAMVFDEALTLKSVAQEEFPQIYPRPGWVEHDPSDLWSSVAATARAAVERAEIDGSLAAIGITNQRETVVVWERASGHPIHNAIVWQDRRTADLCHALAEAGHEPTITERTGLLLDPYFSATKLKWLLDHVEGARARARRGELLFGTVDSYLIWKLTGGRAHVTDATNAARTMLFDIGRGIWDPEICGLLDIPMEMLPEVRDCAAPFGMTRADLFGREIPILGVAGDQQAATCGQACFRPGMMKSTYGTGCFALLNTGEERVTSRARLLTTIAYQLGGKRTYALEGSIFIAGAVVQWLRDGLKIIREAGETQGLALSSDAAQDLVIVPAFTGLGAPWWKPESRGAVFGLTRNSGPAEFARAALESVGYQTRDLLEAMRADWAAGAEGVLRVDGGMAASDWSLQFLADIIGAPVDRPVVRETTALGVAWLAGMQAGLCPGPEEFAADWALERRFEPQMEASVREAKYDRWGRAVRAVMAV
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: TRUA_STAAW
Sequence: MRILVEIAYQGNNFLGFQIQQNGRTVQQQFEKLLQRMHKRHVRIHPSSRTDRGVHAIQQYFHFDTELNIPMSQWQYAMNRTLPDDIYVNNVVTVDDDFHCRYDCVGKRYRYKVYQAQHRDPFQSGLKTFIPETLDLDKMNRAAQQFIGTHDFTGFCSQKTEVESKVRTLYQSEIVKTDDGFDYIVTGSGFLYNMVRVLVAFLIEVGKGRHEISDVPKLLESKNRKNVPFTATAEGLYLEKIYLDENELLKDFGNDIKIHRKKSLQND
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: CH10_CLOB1
Sequence: MNIRPLGDRVVIKRVEAEETTKSGIVLPGAAKEKPQVAEVIAVGPGGLVDGKEVKMELKVGDKVLFSKYAGNEVKIEGEEVTILKQDDILAVVEG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METL1_ARATH
Sequence: MKKKQEESSLEKLSTWYQDGEQDGGDRSEKRRMSLKASDFESSSRSGGSKSKEDNKSVVDVEHQDRDSKRERDGRERTHGSSSDSSKRKRWDEAGGLVNDGDHKSSKLSDSRHDSGGERVSVSNEHGESRRDLKSDRSLKTSSRDEKSKSRGVKDDDRGSPLKKTSGKDGSEVVREVGRSNRSKTPDADYEKEKYSRKDERSRGRDDGWSDRDRDQEGLKDNWKRRHSSSGDKDQKDGDLLYDRGREREFPRQGRERSEGERSHGRLGGRKDGNRGEAVKALSSGGVSNENYDVIEIQTKPHDYVRGESGPNFARMTESGQQPPKKPSNNEEEWAHNQEGRQRSETFGFGSYGEDSRDEAGEASSDYSGAKARNQRGSTPGRTNFVQTPNRGYQTPQGTRGNRPLRGGKGRPAGGRENQQGAIPMPIMGSPFANLGMPPPSPIHSLTPGMSPIPGTSVTPVFMPPFAPTLIWPGARGVDGNMLPVPPVLSPLPPGPSGPRFPSIGTPPNPNMFFTPPGSDRGGPPNFPGSNISGQMGRGMPSDKTSGGWVPPRGGGPPGKAPSRGEQNDYSQNFVDTGMRPQNFIRELELTNVEDYPKLRELIQKKDEIVSNSASAPMYLKGDLHEVELSPELFGTKFDVILVDPPWEEYVHRAPGVSDSMEYWTFEDIINLKIEAIADTPSFLFLWVGDGVGLEQGRQCLKKWGFRRCEDICWVKTNKSNAAPTLRHDSRTVFQRSKEHCLMGIKGTVRRSTDGHIIHANIDTDVIIAEEPPYG
What is the function of this protein?
Probable non-catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs (PubMed:28503769).  Associates with MTA, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences (PubMed:28503769).  N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:28503769).
What are the official names of this protein?
N6-adenosine-methyltransferase non-catalytic subunit MTB, Methyltransferase-like protein 1, Protein EMBRYO DEFECTIVE 1691, Protein METTL14 homolog.
What is the protein family that this protein belongs to?
Belongs to the MT-A70-like family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm.
Protein: RNB_ECO5E
Sequence: MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPEELVEPFLTRFVGKVQGKNDRLAIVPDHPLLKDAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPWWVTLARHNLEKEAPDGVATEMLDEGLVRKDLTALDFVTIDSASTEDMDDALFAKALPDDKLQLIVAIADPTAWIAEGSKLDKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEFFAATIESKAKLVYDQVSDWLENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDKAGTDTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOH_HYDCU
Sequence: MFDALQAWLSSFLFDWLAVLITLVLQAVAVILPVMITVAWLTYAERKVIGYMQVRMGPNRVGPGGWLQPIADAIKAMTKEVVIPAQSNKYLFIIAPILALAPAVAAWAVIPFDANGVVAADINAGVLYVLAVASIGVYGIVISGWASNSKYAFLGALRASAQKISYEIAMGFALVTVLMVADTMNLTGIVEGQQGGIWNWYWIPLLPMFFVYFISGLAETNRAPFDVAEGESEIVAGFHVEYSGMAFAVFFLAEYAMMILISFMTAIMFLGGWYSPFEGIAGLESVFSWVPGFVWLFAKVAFLLFLFLWFRATFPRYRYDQIMRLGWKVLIPVTIVWVFVVGVMEYFKVSPWFN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RF1_ECODH
Sequence: MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLL7_DROME
Sequence: MAAILLLLLGFSWSLAVESALAPKESESSASAMLGAGTGAAATVSLSGDYSSLLSNVPAASPVPANPSQPSGPANQCSWSYNGTSSVHCALRLIERQPGLDLQGADGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGVRVFGPRCEESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRDLAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSDRHFWEKLRYALPVDYPTFRGNNYTLELDHHNHERVKQPASPGLLYRQAPPPAYCGPADAVGIGAVPQVVPVNASVPAEQNYSTATTATPSPRPQRRGEQPGSGSGGNHHLHAQYYQHHGMRPPSEHIYSSIDSDYSTLDNEQHMLMMPGAPGGLAMEAAQRAQTWRPKREQLHLQQAQAGTLGSKASQAAHQQQQQQQQQQQQQPNPTAVSGQQQGPHVQAYLV
What is the function of this protein?
Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553).  Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169).  This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169).  Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726).  Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726).  Also involved in the targeting of other classes of ORN axons (PubMed:25741726).  Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553).  May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).
What are the official names of this protein?
Toll-like receptor 7.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: CCKNA_XENLA
Sequence: MYSGICICLLLAMLSASSKAHQSEDAVVTEMDQLTLSQLPRYARASSAGQKKSFQRTDGDQRSNIGNVLVKYLQQSRKAGPSGRYVVLPNRPIFDQPHRINDRDYMGWMDFGRRSAEEYEYSS
What are the official names of this protein?
Cholecystokinin A, Cholecystokinin type 1.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: JMJ27_ARATH
Sequence: MEKMRGKRIRPRDSGELVEDGRSESERKTRKKENDVVSKGRIGRGRGRGEVSKRSIEIDISNPEKDIKPDGSRKCLGSTCHHCKILTSESDLIFCSKCNKKCYCFDCIKRSYSERTHEEVRAACPFCMMTCICRACLRLPLVIKPPSEKDTDVKLKQLQYLLVKVLPVLKDIYTEQNRELEIESTIRGHPVTEANIKRCKLDPSERIYCDLCRTSIANFHRSCPNKNCSVDICLSCCKELSEGFHQERDGKKNAEGKGYECRIPAGQGKDSDAYVPLHFSTWKLNSDSSIPCPPKECGGCGTSTLELRRLWKRDWVEKLITNAEKCTLNFRPTDVDIVHECSSCSTNSDSIRRQAAFRKNAHDNFLYSPNAVDLAEDDIAHFQFHWMKAEPVIVRNVLEKTSGLSWEPMVMWRACREMDPKRKGTEEETTKVKALDCLDWCEVEINLHQFFEGYLEGRMHKNGWPEMLKLKDWPPSDLFEKRLPRHNAEFIAALPFFDYTDPKSGILNLATRFPEGSLKPDLGPKTYIAYGFHEELNRGDSVTKLHCDISDAVNVLTHTAKVEIPPVKYQNIKVHQKKYAEAMLQKQQYSGQVKEASELENKSMKEVDESKKDLKDKAANEEQSNNSSRPSGSGEAEKVIISKEDNPTQPAVSTSVESIQEQKLDAPKETDGNTNERSKAVHGGAVWDIFRREDVPKLIQFLKRHEHEFRHFNNEPLESVIHPIHDQTMFLSDSQKKQLKEEFDIEPWTFEQHLGEAVFIPAGCPHQVRNRQSCIKVALDFVAPESVEECLRLTQEFRRLPKDHSSSEDKLELKKIALYAASSAIREVKGLMQSSRRSDT
What is the function of this protein?
Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me1 and H3K9me2 (PubMed:28650521, PubMed:34197643).  No activity on H3K4, H3K27, H3K36, H3R2 and H4R3 methyl marks, but weak activity on H3K9me3 (PubMed:28650521, PubMed:34197643).  Involved in regulation of gene expression (PubMed:28650521).  Regulates flowering time by repressing the major flowering regulator CONSTANS (CO) and promoting FLOWERING LOCUS C (FLC) (PubMed:28650521).  Exhibits a positive impact on abscisic acid- (ABA), hydrogen peroxide- (H(2)O(2)) and calcium- (Ca(2+)) induced stomatal closure (PubMed:34197643).  Promotes stomatal-closure-dependent drought-stress responses through its histone demethylase activity toward at least GOLS2 and RD20 loci, thus protecting them from silencing by removing H3K9me2 marks in drought conditions (PubMed:34197643).  Required for plant defenses leading to resistance against the virulent bacterial pathogen Pseudomonas syringae pv.  tomato DC3000 (Pst DC3000) via a negative regulation of WRKY25 (a repressor of defense) and by triggering the expression of several pathogenesis-related (PR) proteins (e. g.  PR1, PR3, PR4 and PR5) (PubMed:28650521).
What are the official names of this protein?
Lysine-specific demethylase JMJ27, Jumonji domain-containing protein 27, AtJMJ27, Protein JUMONJI 27, Lysine-specific histone demethylase JMJ27, [histone H3]-dimethyl-L-lysine(9) monodemethylase JMJ27.
What is the protein family that this protein belongs to?
Belongs to the JARID1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly observed in the nucleus, but also, to a lower extent, in the cytoplasm.
Protein: ACPS_SHIFL
Sequence: MAILGLGTDIVEIARIEAVIARSGERLARRVLSDNEWAIWKTHHQPVRFLAKRFAVKEAAAKAFGTGIRNGLAFNQFEVFNDELGKPRLRLWGEALKLAEKLGVVNMHVTLADERHYACATVIIES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBM47_RAT
Sequence: MTAEDSTTAMNSDPTVGSSTKVPEGVAGAPNEAALLALMERTGYNMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFETVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKRGEILEEIAKVTEGVLNVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMQTVKILYVRNLMIETTEETIKRSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAAKGGGGSAEAVAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKTGSIRGRGRGAAGNRTPGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEISAVNPVAIKPGTVAIPAIGAQYSMFQAAPAPKIIEDGKIHTMEHMISPIAVQPDPATAAAAAAAAAAAAVIPAVSTPPPFQGRPITPVYTVAPNVPRIPTAGIYGASYVPFAAPATATIATLQKNAAAAVYGGYAGYIPQAFPAALQVPIHDVYQTY
What is the function of this protein?
Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing.  Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1.  With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules.  Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10.  Also involved in the alternative splicing of several genes including TJP1.  Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons regulating their exclusion and inclusion into mRNAs (By similarity).  Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity).
What are the official names of this protein?
RNA-binding protein 47, RNA-binding motif protein 47.
What is the protein family that this protein belongs to?
Belongs to the RRM RBM47 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL18_EHRCR
Sequence: MVYNCGTRLERRKKRVRLKLKRNSSLLRLSIFKSNRHFYVQLIDDKCGRTFASASTLEREVVALTNRRVNSDSVKIVAKLMSDRLNKLDNCKKFIFDRGLYKYTGIVSEFANELRSYGFEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: MGMT_KLULA
Sequence: MSHLLVYDFMEHDLANVLIVVKPSTKSLVFVSLSGTKPKLLGDAKKFVSKVNSLSKNKGSIYTLKNKSILKSDDVAWLEQLSFDFLQILAGGIDSQTNIKCEYLLGTEFQKKVWETTKTIKAGATISYQQLAVLLGNPKAVRAIGSALAKNNIAVVIPCHRIIGSKGKLTGFRWGIELKESLLRQEQAI
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, DNA repair MTase, O-6-methylguanine-DNA-alkyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SRC_AVIST
Sequence: MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYLGILAWTPWEDKQEGPRGETASNKQERPGEDTLAADES
What is the function of this protein?
This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro.
What are the official names of this protein?
Tyrosine-protein kinase transforming protein Src, pp60v-src, p60-Src, v-Src.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.