PharMolix/UniProtQA huggingface dataset:
Protein: VPS35_YEAST
Sequence: MAYADSPENAIAVIKQRTALMNRCLSQHKLMESLQHTSIMLTELRNPNLSPKKYYELYVIIFDSLTNLSTYLIENHPQNHHLADLYELVQYTGNVVPRLYLMITVGTSYLTFNEAPKKEILKDMIEMCRGVQNPIRGLFLRYYLSQRTKELLPEDDPSFNSQFIMNNFIEMNKLWVRLQHQGPLRERETRTRERKELQILVGSQLVRLSQIIDDNFQMYKQDILPTILEQVIQCRDLVSQEYLLDVICQVFADEFHLKTLDTLLQTTLHLNPDVSINKIVLTLVDRLNDYVTRQLEDDPNATSTNAYLDMDVFGTFWDYLTVLNHERPDLSLQQFIPLVESVIVLSLKWYPNNFDNLNKLFELVLQKTKDYGQKNISLESEHLFLVLLSFQNSKLQLTSSTTAPPNSPVTSKKHFIFQLISQCQAYKNILALQSISLQKKVVNEIIDILMDREVEEMADNDSESKLHPPGHSAYLVIEDKLQVQRLLSICEPLIISRSGPPANVASSDTNVDEVFFNRHDEEESWILDPIQEKLAHLIHWIMNTTSRKQTMKNKIQFSLEAQLEILLLIKSSFIKGGINVKYTFPAIITNFWKLMRKCRMIQEYLLKKRPDNKTLLSHYSNLLKQMFKFVSRCINDIFNSCNNSCTDLILKLNLQCAILADQLQLNEISYDFFSQAFTIFEESLSDSKTQLQALIYIAQSLQKTRSLYKEAYYDSLIVRCTLHGSKLLKKQDQCRAVYLCSHLWWATEISNIGEEEGITDNFYRDGKRVLECLQRSLRVADSIMDNEQSCELMVEILNRCLYYFIHGDESETHISIKYINGLIELIKTNLKSLKLEDNSASMITNSISDLHITGENNVKASSNADDGSVITDKESNVAIGSDGTYIQLNTLNGSSTLIRGVVATASGSKLLHQLKYIPIHHFRRTCEYIESQREVDDRFKVIYV
What is the function of this protein?
Plays a role in vesicular protein sorting.  Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10.  Vacuolar carboxypeptidase Y (CPY) sorting is completely dependent on the presence of functional VPS35.  The latter may play a role in the function, modification or packaging of a CPY-specific receptor complex.  Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.  The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 35, Vacuolar protein-targeting protein 7.
What is the protein family that this protein belongs to?
Belongs to the VPS35 family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: NADK1_LISIN
Sequence: MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDEIEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIGKKEAEYLALNESTVKSSGGPFVVDVVINDLHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKVHFARFRSFPFWRRVHDSFIED
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase 1, ATP-dependent NAD kinase 1.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CISD2_LITCT
Sequence: MVLEILARVIKVQLPAYLKRLPVPDSIAGFIRLTVSEWLRLLPFLGVLALLGYLAIRPFLPKKKQQKDSLINLKIQKENPKVVNEIDIEDLRIAKVAYCRCWRSKTFPVCDGSHNKHNELTGDNVGPLILKKKEV
What is the function of this protein?
Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum.  Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity).
What are the official names of this protein?
CDGSH iron-sulfur domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the CISD protein family. CISD2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein.
Protein: TCPB_ARATH
Sequence: MPIDKIFKDDASEEKGERARMASFVGAMAISDLVKSTLGPKGMDKILQSTGRGHAVTVTNDGATILKSLHIDNPAAKVLVDISKVQDDEVGDGTTSVVVLAGELLREAEKLVASKIHPMTIIAGYRMASECARNALLKRVIDNKDNAEKFRSDLLKIAMTTLCSKILSQDKEHFAEMAVDAVFRLKGSTNLEAIQIIKKPGGSLKDSFLDEGFILDKKIGIGQPKRIENANILVANTAMDTDKVKIYGARVRVDSMTKVAEIEGAEKEKMKDKVKKIIGHGINCFVNRQLIYNFPEELFADAGILAIEHADFEGIERLGLVTGGEIASTFDNPESVKLGHCKLIEEIMIGEDKLIHFSGCEMGQACSIVLRGASHHVLDEAERSLHDALCVLSQTVNDTRVLLGGGWPEMVMAKEVDELARKTAGKKSHAIEAFSRALVAIPTTIADNAGLDSAELVAQLRAEHHTEGCNAGIDVITGAVGDMEERGIYEAFKVKQAVLLSATEASEMILRVDEIITCAPRRREDRM
What is the function of this protein?
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.  Known to play a role, in vitro, in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit beta, TCP-1-beta, CCT-beta, Chaperonin CCT2.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPR1_MUSTR
Sequence: MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDVQKESSGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVIHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVFAAVFKLETDRTVWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPIYVYPLALYGLMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSFELKWDESKGLLPNDPQEPEFCHKYSYGVRAIVQCIPAWLRFIQCLRRYRDTRRAFPHLVNAGKYSTTFFTVTFAALYSTHKEQNHSDTVVFFYLWVFFCIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITATTFKPHVGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQEDGVRNRQKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANT
What is the function of this protein?
Plays a role in phosphate homeostasis.  Mediates phosphate export from the cell.  Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (By similarity).  Potential receptor for xenotropic and polytropic murine leukemia retroviruses.
What are the official names of this protein?
Xenotropic and polytropic retrovirus receptor 1.
What is the protein family that this protein belongs to?
Belongs to the SYG1 (TC 2.A.94) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL21_ANADE
Sequence: MYAVIRTGGKQYRVAQGDRVKIEKLAGDVGGKVNFDVLLVGGEGEAKVGKPTLAGVTVEGEIVAQGKHKKVIHFRKKKEGWTKKRGHRQPYTEVLITTVRA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: RS6_ALISL
Sequence: MRHYEIVFMVHPDQSEQVAGMIERYTGSITEAGGTIHRLEDWGRRQMAYPINKLHKAHYVLMNVESEQAAIDELETAFRYNDAVLRNMIMRTKAAITEPSVMMKAKEERTAKREDAAPRAEEAAAE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RAB13_DANRE
Sequence: MAKKYDFLFKLLLIGDSGVGKTCLIIRFAEDNFNSTYISTIGIDFKVKTIEVEGKKVKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSYENIQNWMKSIKENASAGVSRMLLGNKCDIEAKRKVSKETGEKLAKEHGIRFFETSAKSSINVEESFTSLARDILLKSNKKPGPSGREVKLTSTEKKSSSKCLLL
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  That Rab may be involved in endocytic recycling and may regulate the transport to the plasma membrane of transmembrane proteins.  May regulate the assembly and the activity of tight junctions.  May play a role in angiogenesis through regulation of endothelial cells chemotaxis.  May be involved in neurite outgrowth.  Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome.  Finally, it has been involved in insulin-induced transport to the plasma membrane of glucose transporters.
What are the official names of this protein?
Ras-related protein Rab-13.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (By similarity). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity).
Protein: RL1_MYCSS
Sequence: MSKNSKAYREAAEKVDKTKLYSPLEAAKLAKETSSKKQDATVEVAIRLGVDPRKADQMVRGTVNLPHGTGKTARVAVFAVGDKAEQAAAAGADIVGSDDLIEQIQGGMLDFDAAIATPDQMAKVGRIARILGPRGLMPNPKTGTVTADVAKAVSDIKGGKINFRVDKQANLHIVIGKASFDEKKLAENYGAALDEILRAKPSASKGRYLKKIVVSTTTGPGIPVDPQVTRNFAEA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: THND_TRIHA
Sequence: MHVLIAGAGLGGLTLAQNLRKRGISYEIFERDEHKDARFQGWAIALHTITDELVASMPSDMPDLRQATDHMSPLKIPTQICLYPAESNVRVGWEDCPETPFIRAERYRLRNHLATNIPIQWGKRVQRIEHDDQGVAVYFEDGTGAKGDILVGADGVKSVVRQQLLQKSHDEVLKIIPLAAIVGELKLSGEAFKRQLQLSHGSYSLIDSEKGYLTFCSLHDVAPDGKSARYYWIMSRSDPTIADPDHWLHKATQQEKLDHAREVMSNREPKFREIFDLTPVEGVKKETHIWRDLELSSLPAGRVVLMGDAAHVMTPFRGEGGYNTFIDAMALAKILDRLDKEDKTHDIESIKNSVNEYNAEMLERGVKSVQLSREWVDGSKVNSKKPLLAPMKVIPFSEVPLEVAA
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that produces the tetronate natural products trihazones (PubMed:33570538).  Transcription analysis of thnD confirmed this gene is expressed, hence its role in the biosynthetic pathway remains cryptic (PubMed:33570538).  The pathway begins with the formation of trihazone A by the hybrid PKS-NRPS synthetase thnA and the trans-enoyl reductase thnE.  Trihazone A is further decarboxylated by the 2-oxoglutarate-dependent dioxygenase thnC to produce trihazone D.  The function of the FAD-dependent monooxygenase thnD has still to be identified (PubMed:33570538).
What are the official names of this protein?
FAD-dependent monooxygenase thnD, Trihazone biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
Protein: DAPD_COXBN
Sequence: MTDLKTIIEEAYQNKDSFTTDTVPKKIHQAIHQTIELLDNGELRIAEKQNGQWNTNEWAKMAILLYFKTEPLKTFDAGYTFFYDKIPLKYTNNTSQPQSGVRVVPHAIVRKGAYLAPNTVLMPSYINIGAYVDSGTLIDTWATVGSCAQIGKNVHLSGGAGIGGVLEPLQAHPTIIEDDCFIGARSEIVEGVMVEKGSVISMGVFVGQSTPIYNRQTQEITYGRIPAGSVVIPGSLPSKDGHYNRYSAIIVKQVDEKTRSKVSLNELLREG
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_ECOSE
Sequence: MATKLQDGNTPCLAATPSEPRPTVLVFDSGVGGLSVYDEIRHLLPDLHYIYAFDNVAFPYGEKSEEFIVERVVAIVTAVQERYPLALAVVACNTASTVSLPALREKFDFPVVGVVPAIKPAARLTANGIVGLLATRGTVKRSYTHELIARFANECQIEMLGSAEMVELAEAKLHGEDVSLDALKRILRPWLRMKEPPDTVVLGCTHFPLLQEELLQVLPEGTRLVDSGAAIARRTAWLLEHEAPDAKSADANIAFCMAMTPEAEQLLPVLQRYGFETLEKLAVLG
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: HCAF_ECO5E
Sequence: MSAQVSLELHHRISQFLFHEASLLDDWKFRDWLAQLDEEICYTMRTTVNAQTRDRRKGVQPPTTWIFNDTKDQLERRIARLETGMAWAEEPPSRTRHLISNCQISETDIPNVFAVRVNYLLYRAQKERDETFYVGTRFDKVRRLEDDNWRLLERDIVLDQAVITSHNLSVLF
What is the function of this protein?
Part of the multicomponent 3-phenylpropionate dioxygenase.  Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.
What are the official names of this protein?
3-phenylpropionate/cinnamic acid dioxygenase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.
Protein: MCD4_CANAL
Sequence: MDRNRQLLLVIGVLFHFFYLWSIFDIYFVSPLVHGMDHHKSTWTPPAKRLFLIVGDGLRADKTFQKLTHPRTGEEKYLAPYLRSLALNNGTWGISNTRMPTESRPGHVAMIAGFYEDVSAVTKGWKENPVDFDSFFNQSKHTYSFGSPDILPMFAFGDGVVPGRIDVCMYGHEFEDFTASSIELDAYVFHHLDELMHNSTTNATLNEELRQDGNVFFLHLLGPDTAGHAYRPYSAEYYENIEYIDRKLEEVIPQINKFFGDDQTAFVFTADHGMSDFGSHGDGHPDNTRTPLIAWGAGVKKPIHLQDVSNLEEQLLKQSPENSGFESTYFDTWELDHLVRNDVNQADIASLMAYLIGANYPANSVGELPLGYIDADPVTKARALYANSLAIVEQYFVKEQEVYNHQFKFKPYSPFEEKSIQKYQQEIESLIDQLEKSGSGSKDEIEKKVIAKIEELMKTTLDGLTYLQTYNWLLLRSIVTLGFFGWIVYSFNIFLKLFVLNEDELKIPPEFSVTLVGIFGALAISINYLLFYQNSPFNYYMYAAFPLYFWYTILNEKKYLITGIESFLHGISNTTKFLIVVSFIGMYEGIAYGFFERVMFSIILIIIGLYPLLVHGAHKVSGLMKTIWFITCLLMCTFTNLDPVKIESLFQINVGTILALIVSIMGTKQVFKRTQVGPIQKQLIIAQIAIIPIILFATNISVLSLQARTGLPLYSQILGWITFIVSLIVLPILHFLNPSSDYQLRLLIIFLTFVPTFIILTISFELLFYVGFSLILLQWLSIEELLKFSHKDLVETFEKTGKLPKGYWLQVIRITIIGFFFLQLAFFGTGNIASISSFSLDSVYRLIPIFDPFSMGALLMIKLIIPYVLLSTCLGIMNHQLEIKKFTISTLIISTSDFLSLNFFFLVRTEGSWLDIGVSISNYCLAILSSLFMLILELISSVVLSGVEYNSDGTKLDFEPISYRVRKRKVT
What is the function of this protein?
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity).
What are the official names of this protein?
GPI ethanolamine phosphate transferase 1.
What is the protein family that this protein belongs to?
Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HSP72_MESAU
Sequence: VEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFDAKRVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKSTAGDTHLGGEDFDNRMVSHLAEEFKRARFEELNADLFRLDKGQIQEIVLVGGSTRLLQDFFNGKELNKITITNDKGRMVQEAERYKGKISEQDK
What is the function of this protein?
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes.  Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation.  This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones.  In the ATP-bound form, it has a low affinity for substrate proteins.  However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins.  It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.  Plays a role in spermatogenesis.  In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells.
What are the official names of this protein?
Heat shock-related 70 kDa protein 2.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with SHCBP1L at spindle during the meiosis process.
Protein: YO263_YEAST
Sequence: MSVNFFSLITSSWERGLFLKSCKNNSGTDSNRFFSFSVPPNLLDNLLPPLLVRKTLSSSSSKSCGIGGIYFKSSAVNVSEDGLTASTFFSILLPKNFLGITKLFCRIFLLSCPHNYKWFIHLINPFEYENFINIE
What are the official names of this protein?
Putative uncharacterized protein YOR263C.
Protein: JEFA_MYCTU
Sequence: MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAGYSLGMAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTVARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPALGGLMVDGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQLTLIPAVALIAYTIIEAPRFDRQSAGFVAALLLAAGVLLWLFVRHEHRAAFPLVDLKLFAEPLYRSVLIVYFVVMSCFFGTLMVITQHFQNVRDLSPLHAGLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCLAAMFIGLAIFAISMDHAHPVALVGLTIFGAGAGGCATPLLHLGMTKVDDGRAGMAAGMLNLQRSLGGIFGVAFLGTIVAAWLGAALPNTMADEIPDPIARAIVVDVIVDSANPHAHAAFIGPGHRITAAQEDEIVLAADAVFVSGIKLALGGAAVLLTGAFVLGWTRFPRTPAS
What is the function of this protein?
Involved in resistance to ethambutol and isoniazid.
What are the official names of this protein?
Drug efflux pump JefA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LPXB_COXB1
Sequence: MSNKSVLLIAGEPSGDLLGAHLAQSLKSLEPNLKLAGMGGKRMREAGVEVFINADKLAVVGLLEILRQFRDIRHAMQTLKRYFKKTPPDLVVFIDYPGFNLHMAKQAKKAGIKVLYYVSPQIWAWRYGRIKKIKKYVDHMAVLFDFEEKLYQKENVPVSFVGHPLANAPTPSLSRNEICKQFNLDLDKPIVALFPGSREQEINKLLPMMVQAGKLIQTQIPTVQFILPLALNLALDKIRPFLSPEIKVIQNDISHVLAIAHAAVAASGTVTLEIALQQVPLVIIYKVAPLTFWLGKKLIRLSFIGLCNLVSPEPVAVELLQQDATPQAIADEVFQLLNNHNYRQSIIGKLGHLRPQLDRGNAAQNVAKVVHNLIFS
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: QUEF_CAUVC
Sequence: MTDLNVTQLGRVVDAPESPEAAVLERVPNPQSDVLYLARFVAPEFTSLCPVTGQPDFAHLVIDYAPGDWLIESKSLKLYLTSFRNHGSFHEDCTVKVARKIVEIAQPRWLRIGGYWYPRGGIPIDVFWQTGPAPEGLWVPDQGVAPYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXA_ECO24
Sequence: MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTDRAAMLGLPLTLRPYSPNSPAQPQTTGTLTLLPVALRESVTAGQLAIENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLDELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGEADVGSFITALNLAIKMIVNTQ
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACEA_ACICA
Sequence: MTYQTAIDAVRELKA
What is the function of this protein?
Involved in the metabolic adaptation in response to environmental changes.  Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.
What are the official names of this protein?
Isocitrate lyase, ICL, Isocitrase, Isocitratase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Protein: Y1076_METJA
Sequence: MRFYNREKELNYLKNYVQLEPNSILFVYGPKSSGKSTVMMRVIKELENSNIVFFYYNLRKYATPTKDEFLSIFFEKSDKKYLLNKLEINLKIFKFGIEENFDFNNIKLNDVFAKINESINTVIKDGKRPVLVIDELQKLKNIYFNSGKSLLNELFNLFVSLTKMEHLCHVICLTSDTLFIDNVYRNSSLSEASEYYLIDWLKKDDIKKILKEEGFNKKEIDYCLNYLSLPYEISQLINNKKLGLSVEETIKRWINIEADGIKYLIDTSDLNEEEIYKVLSKFKDKIKINYKKDVKKEEMKYIKFLIENEILFYDVINGIIKPTSVKKWYAIKEILDK
What are the official names of this protein?
Uncharacterized ATP-binding protein MJ1076.
What is the protein family that this protein belongs to?
Belongs to the archaeal ATPase family.
Protein: RL25_ENT38
Sequence: MFTINAEVRAVQGKGASRRLRAANKFPAIIYGGEAAPVAIEMDQDKVWNQQTKEGFYTEVLTIVIDGKEEKVKVQAVQRHPFKPKLSHVDFVRA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: GLMM_BURVG
Sequence: MGRRYFGTDGIRGTVGDTPITPDFVLRLGYAAGKVLAGAADGATGARPTVLIGKDTRVSGYMLEAALEAGFSAAGVDVMLAGPMPTPGVAYLTRALRLSAGVVISASHNPYQDNGIKFFSADGNKLPDETEAEIEAWLDKPLECASSDRLGKARRLDDAAGRYIEFCKSTFPAAYDLRGLKLVIDCAHGAAYQIAPHVFHELGADVIPIGVAPNGFNINDGVGATAPDALVRAVRANHADLGIALDGDADRLQVVDSSGRLFNGDELLYVLVKDRIATAGKVEGAVGTLMTNLAVEVALQREGVEFVRAAVGDRYVLEQLRERGWQLGAEGSGHILSLDRHSTGDGIVSALLVLAALKRSGRTLAQMLDGVTLFPQKLINVRMKPGADWKGSASIRAAIDAAESALAGHGRVLIRASGTEPVLRVMVEAQQAADATRHAEAIADAVREATS
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: KIF22_MOUSE
Sequence: MSLRAKTCPQRREMASATSGPGRCVSKGGLGRRPPLARVRVAVRLRPFMDGETEAKELPCVRAIDSCSLEVANWKKYQETLKYQFDAFYGEKSTQQEVYVGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLAREESAEGRPWDVSVAMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLTQKPITSFSDFEQHFLPASRNRAVGATRLNQRSSRSHAVLLVKVDQRERLTPFRQREGKLYLIDLAGSEDNRRTGNQGIRLKESGAINTSLFVLGKVVDALNQGLPRIPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALNFTARSKEVINRPFTNESLQPHALAPVKLSQKELLGPSEAKKAKGPEEESTGSPESTAAPASASQKLSLLQKLSNMDPAMLENLLSMERLLGSQGSQGTPLLNTPKRERMVLMKTVEEKNLEIERLKMKQKELEAKVLAQEAPDPREKENTPTILQPPASYSGTVAKPLKKAVVMPLQRIQKQRESSNQIQLLKKGPKRKLEPSPESEAVEKDEDYWEVQISPELLAHGRKKLLDLLNEGSARELRSLQRIGQKKAQLIVGWRELHGPFSEVEDLEQVEGISGKQVESFLKANLLSLAASQHSGPS
What is the function of this protein?
Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis.  Binds to microtubules and to DNA.  Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
What are the official names of this protein?
Kinesin-like protein KIF22.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton.