PharMolix/UniProtQA huggingface dataset:
Protein: RS212_PARXL
Sequence: MTTIRVKDNEPFEVAMRRFKRTMEKTGLLTELRAREFYEKPTAERKRKKAAAVKRHFKRLRGQMLPKKFY
What are the official names of this protein?
30S ribosomal protein S21 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: E1074_IXORI
Sequence: MAFNMITFLQMAVFVVILFNINLHSASAGSKESSAHQSSDDSIKAEFCDAKCTMKTDGKWTQCHGGCFCVHVGNETEGRCMRLDGDYDYPSTQPEE
What is the function of this protein?
Salivary chemokine-binding protein which binds to host chemokines CXCL1 and CXCL8.
What are the official names of this protein?
Evasin P1074.
What are the subcellular locations of this protein?
Secreted.
Protein: Y379_THEGJ
Sequence: MRVIPLASESLGVRSLATFVEAGGIKILIDPGVALGPKRYGLPPAKIELETLQKMRRKIQGYARRADVVTISHYHYDHHTPFFEGLYESSSEEYAREIYAGKLLLIKHPRENINFSQRKRAWAFLKNAEPIARRIEFADGRAFDLGGVTLEFSPAVPHGSEGSRLGFVVMVLIDDGSERIIHASDIQLLNRKAVEWIIEKNPDLLITGGPPTYLGKRAEGSWETGIKNLNEIIRETNAEIILDHHIVRDKRYPEFFDELEKRPKTFAGFLKVEDKPLEAYRRELHKRERGESVELPFRVG
What are the official names of this protein?
UPF0282 protein TGAM_0379.
What is the protein family that this protein belongs to?
Belongs to the UPF0282 family.
Protein: ARNF_PSEAB
Sequence: MNALRGWLAALGSMLLASAAQLGMRWGMSRLPLPEAWAGQTPERAALLAVALAVTAYAASLLCWLAALRHLPLGRAYSLLSASYALVYLLAASLPAFDETFSTSKTLGVGLVVLGVLTVNARRTAAAPAHHPSRKAP
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PURA_LEGPN
Sequence: MGKNVVVLGTQWGDEGKGKIVDLLTQDAQVVVRYQGGHNAGHTLKINGVKTVLRLIPSGMLRPNVTCYIANGVVLSPQALLSEIKELEGNGINVRERLRISLACPLILPYHIALDKARETHMGKSAIGTTGRGIGPAYEDKVARRALRVGDLFHRDRFANKLTELLDYHNFVLTQYFKQPAVDLESLLGESLQWAEELRPMVCDVSACLHEHRKQGENILFEGAQGVYLDIDHGTYPYVTSSNTCVGSVINGAGFGPRYIDYVLGITKAYTTRVGGGPFPTELLDDVGKRIAERGQEFGAVTGRPRRCGWFDAVLLKRSIELNSISGLCVTKLDVLDGLEVLRIAVAYKDRDGNILSRPPLAADDFNDLLPVYEELPGWQESTADVTVMSDLPANARAYLKRIEEILGIPIDMLSTGPERDSTITLRGPFL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDIQ_ECOLI
Sequence: MKIITCFKLVPEEQDIVVTPEYTLNFDNADAKISQFDLNAIEAASQLATDDDEIAALTVGGSLLQNSKVRKDVLSRGPHSLYLVQDAQLEHALPLDTAKALAAAIEKIGFDLLIFGEGSGDLYAQQVGLLVGEILQLPVINAVSAIQRQGNTLVIERTLEDDVEVIELSVPAVLCVTSDINVPRIPSMKAILGAGKKPVNQWQASDIDWSQSAPLAELVGIRVPPQTERKHIIIDNDSPEAIAELAEHLKKALN
What is the function of this protein?
May play a role in a redox process.
What are the official names of this protein?
Putative electron transfer flavoprotein subunit YdiQ.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: THII_SERP5
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILSTSIRNVLKQYDETLAVVRHWDHIEVRAKDENQRPVIADALTRIPGIHHILEVEDRDYTDIHHIFEQTLEAYREQLEGKTFCVRVKRRGKQDFNSQDVERYVGGGLNQHIESARVKLSHPQVTVNLEIENDKLMLVKARREGIGGYPVGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFASSHKVRFIAIDFEPVVGEILEKVEDGQMGVVLKRMMVRAASQIAERYGVQALVTGEALGQVSSQTLTNLRLIDNASDTLILRPLISHDKEHIIKVAREIGTEDFAKTMPEYCGVISKSPTVKAIKAKIEEEEGHFDFSILDRVVSEAKNVDIRTIAEQTQEQVTEVETVAEFDADQVILDIRSNDEQEDKPLKLDQVEVKPLPFYKLSTQFGDLDQSKTYLLYCERGVMSRLQALYLLEQGFTNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1499_BURPS
Sequence: MMKGQLAGLMKQAQQMQENMKKMQEQLALIEVEGQSGAGLVKVTMTCRNEVRRVAIDPSLLADDKDMLEDLVAAAFNDAVRKAEATSQEKMSGMTSGLPLPPGFKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein BPSL1499.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: HSLV_RHIEC
Sequence: MTTIITVRKGGKVVMAGDGQVSLGQTVMKGNARKVRRIGKGDVIAGFAGATADAFTLLERLEKKLEQYPGQLMRAAVELAKDWRTDKYLRNLEAMMLVADKSITLAITGNGDVLEPEHGTTAIGSGGNFAFAAARALMDTDKPAEEIARRALDIAADICVYTNHNIVVELLDVES
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNZ_STRA3
Sequence: MEIQFLGTGAGQPAKARNVSSLVLKLLDEINEVWMFDCGEGTQRQILETTIKPRKVKKIFITHMHGDHVFGLPGFLSSRAFQANEEQTDLDIYGPVGIKSFVMTGLRTSGSRLPYRIHFHEFDESSLGKIMETDKFTVYAEKLDHTIFCMGYRVVQKDLEGTLDAEALKLAGVPFGPLFGKVKNGENVTLEDGREIIAKDYISEPKKGKVITILGDTRKTDASIRLALGADVLVHESTYGKGDERIAKSHGHSTNMQAADIAKQANAKRLLLNHVSARFMGRDCWQMEEDAKTIFSNTHLVRDLEEVGI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: PSBD_PIPCE
Sequence: MTIALGRFTKEEEKDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFALIGFMLRQFELARSVQLRPYNAIAFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLVFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NTAQ1_DROMO
Sequence: MATDFLFPKIADCSYVSCYCEENVWKLCEQVQRTRPEELSKCYAVFVSNEGRTVPLWRQKAGRGDDQVVIWDYHVFFMHNPLPNRCLVYDLDTTLPFPTYFHKYVTETFRSDLALRPEHHRFFRVIPADTYLIEFSSDRRHMRRPDGSWIKPPPSYPPILSNTNMHCLGDFICMSAGKGPGAVYSLSEFVQYFYKSPHVVAQHNK
What is the function of this protein?
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation.  Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.  Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
What are the official names of this protein?
Protein N-terminal glutamine amidohydrolase, Protein NH2-terminal glutamine deamidase, N-terminal Gln amidase, Nt(Q)-amidase, Protein tungus.
What is the protein family that this protein belongs to?
Belongs to the NTAQ1 family.
Protein: SYT_LEVBA
Sequence: MADISIKFPDGAVKAFPAGTTPADVAKSISISLAKKAVAAKLDGQLVDYLTPLASDGSIEIVTKDSDDGLTVLRNTTAALLRIALKKEFPAIRLGKVSADEDGFFVDTDKDDQQVSVDELDALAVIVEKLVSDKLDIERITVSKADALADAKDDQFTTALINAVDGDSVPFLKIGDYQILSDGAQLTNTGDVKKFKLLSVAGAYWQGKSSNPMLQRIYGTAFYKQADLDADLARRQEARERDHRVIGNQLDLFFVDPKVGAGLPYWMPNGATIRRTIERYIIDKEVSNGYQHVYTPVLANLDLYKQSGHWAHYREDMFPPMDMGDGEMLELRPMNCPSHIQVYNHHIRSYRELPLRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVAPEQIQDEFKSILDLMVKVYADFDIKDYTFRLSYRDPKNTEKYFDDDEMWNNAQAMLKGAMDDLGLPYVEAEGEAAFYGPKLDVQTKTALGNEETLSTIQLDFMLPERFDLHYVGADGEEHRPVMIHRGLVSTMERFTAYLTEIYKGAFPTWLAPKQVTIIPVSEEKHGAYADKLAAELKAADIRVNVDKRGEKMGYLIRDAQTHKIPYTLVVGEDEMSNGSVSVRKYGENQTTSMSSDAFVKEILADIASYSREND
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIPA_HISS2
Sequence: MDLNAILIILGVIALIILVAHGIWSNRREKSQYFENSKNFTREARIREPQENQQYQTADQSQSDFQRNLLETDNDCFSSESAHNSHQPLYHYSEQSAVQSVDQIKIRLPDSEPNYVMQEQFSPKHTDYASMSIEELEKSIDLDEGINSSSQHLRQELAQISGQSIADDKVNIEEHIFTESSISFVEPQTNTEFQQVVEKTKSGNSSFIMLYVVASENQGFSGLQLTKTLDELGFIFGKKQIYHRHVDLSITSPVLFSVANIEQPGTFDLTNIADFYTVGIALFMQLPSYGNVTANLRMMIRAAKTIAQDLDGVVVTEQQEIFDEQAERDYLARVS
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: RL14_SALAR
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVILNNNSEQPIGTRIFGPVTRELRNEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: F16PC_CLOBH
Sequence: MTLYDENNLHIIKDNLRYLKLLSKQYPSISSASSEIINLQAILNLPKGTEHFISDVHGEYESFTHMLKNASGVIKRKIDDVFGTSLRECDKKNLATLIYYPEQKLDLIKKSEKNLEDWYKITLYRLIRLCQIVSSKYTRSKVRKSLPSDFAYIIEELLNEQGDRVDKQEYYNSIIETIIDIDRASEFIIAISNVIQRLVVDKLHIIGDIYDRGPGAEIIIEALSKHHSIDIQWGNHDIVWMGAAAGCEACIANVIRISLRYANLSTLEDGYGINLLPLATFAMDFYKEDNCENFKPRTIDKNLNETDIKLLSKMHKAISIIQFKLEGKIIKRRPEFKMGERLLLDKINIKEGTLNLNEKIYKLIDTNFPTLDKENPYELNERERDLVEKLTNSFINSEKLQRHIKFLYSNGNLYLKYNSNLLYHGCIPLNEDGSLKEVTLCKETLKGKSLLDKLDRLAREAYFFKKDPESKLYGMDMMWYLWCGSNSPLFGKKKMTTFERYFLDDKNTHKEQKNPYYKYRNDEKMCTMIFEEFELDADNSHIINGHIPVKTKEGENPIKANGKLLVIDGGFCKAYQPQTGIAGYTLIYNSYGLLLTSHEPFSSIHKAIVEGNDILSSTTILEHVSSRKRVLDTDSGEEIKKQIHDLEMLLVAYRKGLIKEENEANIRF
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 3, FBPase class 3, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 3 family.
Protein: KBAZ_ECOHS
Sequence: MKHLTEMVRQHKAGKTNAIYAVCSAHPLVLEAAIRYASANQTPLLIEATSNQVDQFGGYTGMTPADFRGFVCQLADSLNFPQDALILGGDHLGPNRWQNLPAAQAMANADDLIKSYVAAGFKKIHLDCSMSCQDDPIPLTDDIVAERAARLAKVAEETCLEHFGEADLEYVIGTEVPVPGGAHETLSELAVTTPDAARATLEAHRHAFEKQGLNAIWPRIIALVVQPGVEFDHTNVIDYQPAKASALSQMVENYETLIFEAHSTDYQTPQSLRQLVIDHFAILKVGPALTFALREALFSLAAIEEELVPAKVCSGLRQVLEDVMLDRPEYWQSHYHGDGNARRLARGYSYSDRVRYYWPDSQIDDAFAHLVRNLADSPIPLPLISQYLPLQYVKVRSGELQPTPRELIINHIQDILAQYHTACEGQ
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of KbaY.  When expressed alone, KbaZ does not show any aldolase activity.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. KbaZ subfamily.
Protein: HLYC_RICB8
Sequence: MLKSSKKEDDSKKNHDNKSIFHLRKLFSPIKSLFSNKVPDDFFSVIKRLKTNSQKMTLDERNILANLLKLKGKTIEDIMVPRSDIAAIKLTTNIEELNESIKVKIPHTRTLIYDGTLDNIVGFIHIKDLFKALVTKQNFRLKKLIRKHIIAAPSMKLLDLLAKMRREKTHIAIVIDEYGGTDGLVTIEDVMEALVGRIDDEHDQKSEYDNYKVINNSTIISNARVEVEVLEEIIGEKLKDDDDDEFDTIGGLVLTKMGNVPAVGTKINVSENIEIEVTDANPRSLKQVKITLKNSLKRAKSS
What are the official names of this protein?
Possible hemolysin C.
What is the protein family that this protein belongs to?
Belongs to the UPF0053 family. Hemolysin C subfamily.
Protein: NOP9_EMENI
Sequence: MPRENQKRGRRATEKAKKEASKRKRDEGIEEPTLKRLKPSADEDNAVTAGADYVPLEGEEYDDQYATGAADEMPFYGLLDSEEQEYFSRANEMLELNQFGDAEERRLFVDSVFREARGKELKIACSQSCSRLMEKLISVSDIHQIWRLFNKFIGHFLTLVQHRFASHCCERLFISAAPGVTQKASKTKSKKDDDIEMDEDEEPEPELPLAEMFMKVVEELQGNWGYLLTERFASHTIRVLLLVLAGEPVDVSSNDSVVASRKKERLGVVGGETQENNPSGEKRSVPESFEATLKKVMQDMVSVLDDTYLRALATHPVGNPVLQVLVRLELSHFGKSSAKQPTSIIKRLIPDENFEDDSETTRFIRGLLYDPVGSRLLETMVRCMPGKMFKSLYRNYLRDQMSSLARNQTAGYVVLRVLERLGRDDLHAVMEQIVPKIPSLIERSRTIVPKVLIERCLARGVDTKPIAKALESSYDSDPARRLEQMLRLETAMADNKEKSDKNGPPGESNPGSAAAEKLHGSLLAQTIVTAPGQLSELVFSSLLALSPEVLLSICKDPTASRVIQQALTSPASSPQFRRQFTTRFTSHMNELALDSSGSHVVDALWPATKDIYFIKERMAQELAQNELALRDSFVGRAVWRNWAMDLYKRRRGEWAAKAKGRDITNDSAEKPKSRLDMARARYAAKQSEATGANAVAAKQ
What is the function of this protein?
RNA-binding nucleolar protein required for pre-rRNA processing.  Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity).
What are the official names of this protein?
Nucleolar protein 9, Pumilio domain-containing protein nop9.
What is the protein family that this protein belongs to?
Belongs to the NOP9 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HSCB_VIBC1
Sequence: MNHFELFGLPSQFQLDGSLLSSQFRELQKRFHPDNFATASERDRLMAVQKAAQINDAYQVLKHPISRAEYILAENGTEIRGEQQTMQDPMFLMEQMELREELEDIADSSDPESALFDFDSKVSKMYKQHLASVEQELDQGLWAEAADRVRKLKFIAKLKNEIELVEDKLLG
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: PSTS_STAES
Sequence: MKKWQLVGTTVLGASVLLGACGGNDGGSGDGKDLKGSAKGEGSSTVAPIVEKLNEKWAKDHKDAKISSGQAGTGAGFQKFIAGETDFSDASRPIKDEEKKKLEDKGIKYHEFKIAQDGVTIAVNKDNDFVKELTKSQLKDIYSGKAKTWKDVNSSWPDKKINAVSPNSSHGTYDFFEEEVMDKQDIKAEKNADTNAIVSSVTKNKEGIGYFGYNFYEQNKDKLKEVKIKDDNGKVTEPTKKTIQNGSYALSRPLFIYAKDKSLKDNKVMSEFMKFVLEDEGKAAEDAGYVASPKKTYKSQLDDLKDFLDKHQKSDKKDDKKSEDK
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.
What are the official names of this protein?
Phosphate-binding protein PstS, PBP.
What is the protein family that this protein belongs to?
Belongs to the PstS family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: TOP1_VACCC
Sequence: MRALFYKDGKLFTDNNFLNPVSDDNPAYEVLQHVKIPTHLTDVVVYEQTWEEALTRLIFVGSDSKGRRQYFYGKMHVQNRNAKRDRIFVRVYNVMKRINCFINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKNKHIEISPDEIVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLFNKLSERKVYECIKQFGIRIKDLRTYGVNYTFLYNFWTNVKSISPLPSPKKLIALTIKQTAEVVGHTPSISKRAYMATTILEMVKDKNFLDVVSKTTFDEFLSIVVDHVKSSTDG
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1B, TopIB, DNA topoisomerase I, Late protein H6.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
Protein: RLR69_PLAVT
Sequence: MHSSTILFVLGAAILAVNGVTTALIDDEVDKGTQEKHRLLRSNLMKHETGEERFELPAWFIGSKAYKQRKRERYEQAKRYYYTLVQDKNHDETFRELDTKRKTLKSALKFIAWNYKGFSNYTKRRIRKKYTAYRIKNPRPW
What is the function of this protein?
Secreted effector that completely suppresses the host cell death induced by cell death-inducing proteins.
What are the official names of this protein?
Secreted RxLR effector protein 69.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: HTPX_TROW8
Sequence: MMYSFIARNKINTFLILFVFILACGGFGLLAGRFLGMSFFLFILLLAAGYACVQYFFSGRLAVLMSGARKISRNDNPRLWNTVENLSITTGLPMPEVYIVDDPAPNAFATGRDPKHAKVAATSGLLEILDDSELEGVMAHEMGHVKNYDIRVSTIVFGLVSAVGLISDMVLRALIWGDNRREGNSAFSFAIVLFFSLLAPIAAMLVQLAVSREREYLADATGALTTRYPAALASALAKLEGNARPLQRQSSSMAHLWISNPMPRGFFRKLFSTHPPTEERIRRLKEMGNQF
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS3A_KOMPG
Sequence: MAVGKNKRLSKGKKGLKKKVVDPFQRKEWYDIKAPTTFENRNVGKTLINKSTGLKNAVDGLKGRVVEVSLADLQGSEDHSFKKIKLRVDEVQGKNLLTNFHGFDFTSDKVRSLVRKWQSLVEANVTVKTADDYVLRIFCIAFTRRHQNQIKKTTYAQSSQLSAIRKKMVEIMQREVSNVTLAQLTSKLIPEVIGREIEKAAEGIYPLQNVHIRKVKVLKQAKFDLGALLALHGESVTEENGKKVGSEFQDVVLETV
What are the official names of this protein?
40S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOLC1_BACCZ
Sequence: MNPLIFKENRPFDLIAVGRLCVDLNANETQRPMEETRTFTKYVGGSPANIAIGAARLGLQTGFIGKVSDDQMGRFITGYLKDNKINTDQIRIDCTGAVTGLAFTEIKSPEDCSILMYRDNVADLNLDPTEVSEDYIKQSKALLISGTALAKSPSREAVFLALEYARKHDVVVFFDVDYRPYTWQSEAETAVYYNLAAEKSDVIIGTREEFDMMEKLLNYEQSNDQVTAERWFSHYAKIVVIKHGGDGSIAYTRDGQSHRGGIFKTKVLKTFGAGDSYASAFIYGLIQGLEIPQAMRLGGASASIVISKHSCSDAMPTRAEISAFMETAEELV
What is the function of this protein?
Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).
What are the official names of this protein?
5-dehydro-2-deoxygluconokinase 1, 2-deoxy-5-keto-D-gluconate kinase 1, DKG kinase 1.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: CDK1_HUMAN
Sequence: MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
What is the function of this protein?
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.
What are the official names of this protein?
Cyclin-dependent kinase 1, CDK1, Cell division control protein 2 homolog, Cell division protein kinase 1, p34 protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
Protein: RK20_PROWI
Sequence: MTRVKRGNIARNRRNEILDLAKGFRGSSSKLYRTAQQRTIKALTNSYKDRKNKKREFVKIWVSRINAAVRLSGLNYSSFQNQLKFHKIRLNRKICSQIALQDQESFTKLLDLII
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, plastid.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid.
Protein: GRGF_PENSQ
Sequence: MTASTLPRSDVEFTTLDGLTLRGWLFPASQRGPALIMSPGFNMPKDAILPDIAKWFQEHGITCLLYDPRGIGASDGEPRNDIDARQQAEHLHDAVTWFKENPLVNEKQIALWGLCFGGNVTLAAAAFDKRVAAAIAVAPLIDSTGNPERRQPILELAMHDRASRLDGEEPMYLPYVNEDGSIPNGLQLAAEMMPALERLGIPVENRISVQTYYKSLSWNILNVVQYISPTPAMMVTPELDVSCPTEDQLNCFEHMKEPKELDILKGKGHLDWVFGDVESILNRQLDFLKRHMAF
What is the function of this protein?
Polyketide transferase; part of the gene cluster that mediates the biosynthesis of gregatin A, a fungal polyketide featuring an alkylated furanone core (PubMed:32275405).  The PKS grgA synthesizes C11 and C4 polyketide chains in the presence and absence of the trans-enoyl reductase grgB, respectively (PubMed:32275405).  The polyketide transferase grgF is then responsible for the fusion of the two carbon chains to produce the furanone skeleton of gregatin A (PubMed:32275405).  GrgF first undergoes a conformational change to an open form, and the active site Cys-115 is acylated by the C11 chain.  After the elimination of the phosphopantetheinyl chain, the second polyketide chain of four carbons long is delivered adjacent to the enzyme-bound C11 chain.  The catalytic histidine, His-269, deprotonates a proton from C-2 of the long chain, and the resultant carbanion attacks the C-1 carbonyl of the crotonyl group to perform Claisen condensation, by which the phosphopantetheinyl chain is released.  Eventually, hydrolysis of the thioester linkage probably by a His-269-activated water molecule completes the reaction to afford the grgF final product (PubMed:32275405).  Next, the cytochrome P450 monooxygenase grgG accepts the unstable grgF final product as substrate and performs the oxidative cyclization to furnish the gregatin scaffold and leads to the formation of desmethylgregatin A (PubMed:32275405).  Finally, the O-methyltransferase grgD methylates the carboxyl group of desmethylgregatin A to provide gregatin A (PubMed:32275405).
What are the official names of this protein?
Polyketide transferase grgF, Gregatin A biosynthesis cluster protein F, Hydrolase grgF.
What is the protein family that this protein belongs to?
Belongs to the polyketide transferase af380 family.