PharMolix/UniProtQA huggingface dataset:
Protein: COX1_CAEEL
Sequence: MNLYKKYQGGLAVWLESSNHKDIGTLYFIFGLWSGMVGTSFSLLIRLELAKPGFFLSNGQLYNSVITAHAILMIFFMVMPTMIGGFGNWLLPLMLGAPDMSFPRLNNLSFWLLPTSMLLILDACFVDMGCGTSWTVYPPLSTMGHPGSSVDLAIFSLHAAGLSSILGGINFMCTTKNLRSSSISLEHMTLFVWTVFVTVFLLVLSLPVLAGAITMLLTDRNLNTSFFDPSTGGNPLIYQHLFWFFGHPEVYILILPAFGIVSQSTLYLTGKKEVFGALGMVYAILSIGLIGCVVWAHHMYTVGMDLDSRAYFSAATMVIAVPTGVKVFSWLATLFGMKMVFNPLLLWVLGFIFLFTLGGLTGVVLSNSSLDIILHDTYYVVSHFHYVLSLGAVFGIFTGVTLWWSFITGYVLDKLMMSAVFILLFIGVNLTFFPLHFAGLHGFPRKYLDYPDVYSVWNIIASYGSIISTAGLFLFIYVLLESFFSYRLVISDYYSNSSPEYCMSNYVFGHSYQSEIYFSTTSLKN
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LYTH_BACSU
Sequence: MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQIPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVFDGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISEFMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVKSTCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVGSSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK
What is the function of this protein?
L-Ala--D-Glu endopeptidase involved in production of single L-alanine side chains from tetrapeptides in the spore cortex peptidoglycan.  Therefore, is required for the endospore cortex maturation.
What are the official names of this protein?
L-Ala--D-Glu endopeptidase, Peptidoglycan hydrolase, Sporulation-specific endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M23B family.
Protein: LIPB_AERS4
Sequence: MSLQIPAQPQLLVRQLGRRPYQPVWDAMKAFTDNRTSDTPDEFWVVEHDPVYTQGQAGKAEHLLAPGDIPVVQSDRGGQVTYHGPGQLVLYVLVDVRRSKLSVRELVTCLETAIINTLAKSDIQAYAKADAPGVYVTNELGMEAKLASLGLRIRKGCSFHGLALNINMDMTPFLRINPCGYAGMAMTQTSALGGPQSVAEAQAILVAELASLIGYQTITNADDTP
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NWK_DROME
Sequence: MQPPPRKGNYVKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYPVLKQHIQYDFEACDNDPVRKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKCTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDIDQETAGSAFNGTSGNQLRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIKIITKTAHGVDDGWWEGELDGKFGNFPSLVVEECDEMGEPLSEGGDESPPPTAAPTFALPPAPALPPEYAHELELELTEDMFGSQDTADEDSGYIPNGAAAPSIPPPVLIQEPGMEDDLSDDGQPPPSLPPPQLAKAGGSAPGSGSKVEKGAAAGGANTLNLGMAQIIVTAATPMVEDGADKSFPPVGESDAQPVEPVSKEQPAEVAKKPDIAPKPLAKVAPQSAPAKEGNAGVRPVVSITLTEYPSCDAEDQQSFSEGTDSASVADVPVLQDAEDPFNEKAKGESGDGSGFEANFEANFDANFDDAFAGIGGGGGGGGGGGEQSNELDINGEAAGEAIVSGSAAGDEDIEAPKQVVGGRASIPEELDSNQLAHYHEHEIYYVDYSHGQL
What is the function of this protein?
Adapter protein that provides a link between vesicular membrane traffic and the actin assembly machinery.  Acts together with Cdc42 to stimulate actin nucleation mediated by WASp and the ARP2/3 complex (PubMed:18701694, PubMed:27601635).  Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and causes local membrane deformation (PubMed:23761074, PubMed:26686642).  Required for normal structure and function of synapses at the neuromuscular junction (PubMed:18701694, PubMed:14980202, PubMed:18498733, PubMed:21464232, PubMed:26686642, PubMed:26567222, PubMed:27601635, PubMed:29568072).  Plays a role in synaptic vesicle trafficking (PubMed:29568072).  Required for the release of a normal number of synaptic vesicles per action potential (PubMed:26567222).
What are the official names of this protein?
Protein nervous wreck, Nwk.
What are the subcellular locations of this protein?
Endomembrane system. Synapse. Cell projection, axon. Presynaptic cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Recycling endosome. Note=Detected at presynaptic axon terminals at the neuromuscular junction (PubMed:14980202, PubMed:18701694, PubMed:21464232, PubMed:26686642, PubMed:26567222, PubMed:27601635, PubMed:29568072). Colocalizes with Cdc42 and Rab11 (PubMed:18701694, PubMed:21464232).
Protein: MTND_XYLFA
Sequence: MSRLRIFDDHTPDTPFFVSKEQTQITAELHKIGITFERWEATQAIEPGATPEQVMAAYRADIDRLIATHGFKTVDVVSIAPDNPKREEMRAKFLEEHFHKEDEVRFFVAGSGLFTVHSGNKVYEIECVKNDLIAIPDGTQHWFDMGAAPYFVAIRFFTEPDGWVGHFTGTDIAQRFPRYIPEGCQSAH
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: QUEA_ECOK1
Sequence: MRVTDFSFELPESLIAHYPMPERSSCRLLSLDGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGKIEVLVERMLDEKRILAHIRASKAPKPGAELLLGDDESINATMTARHGALFEVEFNDDRSVLDILNSIGHIPLPPYIDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLEKLRAKGVEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQDVVEAVLAAKARGNRVIAVGTTSVRSLESAAQAAKNDLIEPFFDDTQIFIYPGFQYKVVDALVTNFHLPESTLIMLVSAFAGYQHTMNAYKAAVEEKYRFFSYGDAMFITYNPQAINERVGE
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERAP1_RAT
Sequence: MPSLLSLVLTFLAVSSPSCCQNSDTASPKASNGASFPWNNMRLPEYITPIHYDLMIHANLSTLTFWGKTEVEITVSQPTSTIIMHSHQLQISKATLRRGAEEMLPEEPLKLMEYSAHEQVALLTAQPLLAGSVYTVIITYAANLSENFHGFYKSTYRTQEGERRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVTVAEGLIEDHFDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLYDKEKSSASSKLGITMTVSHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVEEYFFGKCFNAMEVDALNSSHPVSTPVENPAQIREMFDEVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRNQHSSSTSHWRQEVIDIKSMMNTWTLQKGFPLITITVRGRNVHLKQEHYMKGSECFPETGSLWHVPLTFITSKSDSVQRFLLKTKTDVIILPEAVEWIKFNVGMNGYYIVHYGDDGWASLNGLLKEAHTTISSNDRASLINNAFQLVSIGKLSIEKALDLILYLKNETEIMPIFQGLNELIPMYKLMEKRDMVEVETQFKDFLLRLLKDLINKQTWTDEGSVSERMLRSQLLLLACVHRYQLCVQRAERYFREWKASNGNMSLPIDVTLAVFAVGAQNTEGWDFLYSKYQSSLSSTEKSQIEFSLCISQDPEKLQWLLDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLKENWNKIVQKFELGSSSIAHMVMGTTNQFSTRARLEEVKGFFSSLKKNGSQLRCVQQTIETIEENIRWMDKNFDKIRLWLQKERQELL
What is the function of this protein?
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides.  Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules.  Strongly prefers substrates 9-16 residues long.  Rapidly degrades 13-mer to a 9-mer and then stops.  Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus.  May play a role in the inactivation of peptide hormones.  May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity).
What are the official names of this protein?
Endoplasmic reticulum aminopeptidase 1, ARTS-1, Adipocyte-derived leucine aminopeptidase, A-LAP, Aminopeptidase PILS, Puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: YHBP_ECO55
Sequence: METLIAISRWLAKQHVVTWCVQQEGELWCANAFYLFDAQKVAFYILTEEKTRHAQMSGPQAAVAGTVNGQPKTVALIRGVQFKGEIRRLEGEESDLARKAYNRRFPVARMLSAPVWEIRLDEIKFTDNTLGFGKKMIWLRDSGTEQA
What are the official names of this protein?
UPF0306 protein YhbP.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: IF2_THEAB
Sequence: MARLRVYELARQLEMDTRELMKELHELGIEIKSHMSYIDEETVNLLLEMYGTQEEEEELIEEYEEYEEIDEEVNGKHFKNKEGSLEKLQTNKKKNSVKITEEDLKLDKFAEKIGIPQNKIIQDFFMKGEILKPGQSLNLQLAKKIAKMYDVRISFENEEKEEVIENPLIEIEKYFEEKYKNPENLKERPPVVTVMGHVDHGKTTLLDYIRNTRVAEREEGGITQSIGAYQVEVNGKKITFIDTPGHEIFTEMRARGAQATDIVVLVVAADDGVMPQTIEAYNHAKSANVPIIVAINKIDKPNANVEKTKQELVNKLNLIPEEWGGDTIVVPISAKKGQNVDTLLEMILLVAEMQEIKGIPDGPVRAVTIESKLDKGFGPVANVIVKDGILKIGDYIISGKVMGKVKALVNDQGKRVKEAGPSTPVMIVGFEELPDSHGIVYSVDSLDKAREISEKIREIEQKELRRKRHMKLEEILKMMEQSERKELRLVLKADTQGSLMALSGAINKLRSEEISINIIHSGVGSITVSDVMLATASDAIILGFRVKADSQARKMAEAEGIQIKTYTIVYKLIEELQAALEGMLEPEEIEEITGRGEIKKVFKIKKVGSIAGVQMIEGYVEKDGLVKVYRSGKLVYEGKIESLKHYQQDVKRVDAPQECGIKLENFDDIKEGDELEFSVLKKVARKLTFEEDKGEK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROP_ECOLI
Sequence: MMEGQQHGEQLKRGLKNRHIQLIALGGAIGTGLFLGSASVIQSAGPGIILGYAIAGFIAFLIMRQLGEMVVEEPVAGSFSHFAYKYWGSFAGFASGWNYWVLYVLVAMAELTAVGKYIQFWYPEIPTWVSAAVFFVVINAINLTNVKVFGEMEFWFAIIKVIAVVAMIIFGGWLLFSGNGGPQATVSNLWDQGGFLPHGFTGLVMMMAIIMFSFGGLELVGITAAEADNPEQSIPKATNQVIYRILIFYIGSLAVLLSLMPWTRVTADTSPFVLIFHELGDTFVANALNIVVLTAALSVYNSCVYCNSRMLFGLAQQGNAPKALASVDKRGVPVNTILVSALVTALCVLINYLAPESAFGLLMALVVSALVINWAMISLAHMKFRRAKQEQGVVTRFPALLYPLGNWICLLFMAAVLVIMLMTPGMAISVYLIPVWLIVLGIGYLFKEKTAKAVKAH
What is the function of this protein?
Permease that is involved in the active transport across the cytoplasmic membrane of all three aromatic amino acids, phenylalanine, tyrosine and tryptophan.
What are the official names of this protein?
Aromatic amino acid transport protein AroP, Aromatic amino acid:H(+) symporter AroP, General aromatic amino acid permease, General aromatic transport system.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FUMC_STRCO
Sequence: MSEYRIEHDSMGEVRVPADAKWRAQTQRAVENFPVSGQRIERAHIEALARIKSAAAKVNAELGVLDEDVAGAIQEAAGEVAEGKWDEHFPVDVFQTGSGTSSNMNTNEVVATLATERLGRDVHPNDHVNASQSSNDVFPSSIHIAATAAVTRDLIPALDHLAGALERKAGEFADVVKSGRTHLMDATPVTLGQEFGGYAAQVRYGIERLQASLPRLAELPLGGTAVGTGINTPPGFSAAVIEEVARATGLPLTEARDHFEAQGARDGIVETSGQLRTIGVGLTKIANDLRWMASGPRTGLAEISLPDLQPGSSIMPGKVNPVIPEAVLMVAAQVTGNDATVAAAGAAGNFELNVMLPVIAKNVLESVRLLANVSRLLADRTVDGIVAHPERAREYAESSPSVVTPLNKYLGYEEAAKVAKRALAERKTIRQTVLEGGYVERGDLTREQLDQALDVLRMTRP
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_RHIWR
Sequence: MAIRLILEAPDPRLRTISTPVEAVDDELRALIADMFETMYDAPGIGLAAIQVGVPKRVLVIDLQEEEDAEGKPIRHPRVFINPELFDPSEEQSVYNEGCLSVPEQYAEVERPAVIHARWLDEQGAKHEERLEGLLATCLQHEMDHLEGILFIDHLSRLKREMVMKKLEKARRARKAA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: METXS_BURP1
Sequence: MESIGVVAPHTMHFAEPLRLQSGSVLGNYQLVVETYGELNAVRSNAVLVCHALNASHHVAGVYADDPRSTGWWDNMVGPGKPLDTNRFFVIGVNNLGSCFGSTGPMNIDPATGTPYGARFPVVTVEDWVHAQARVADALGIERFAAVMGGSLGGMQALAWSLLYPERVAHCIDIASTPKLSAQNIAFNEVARSAILSDPDFHGGDYYAHGVKPRRGLRVARMIGHITYLSDDDMAEKFGRALRRADGALDAYNFNFDVEFEVESYLRYQGDKFADYFDANTYLLITRALDYFDPAKAFNGDLSAALAHTKAKYLIASFMTDWRFAPARSREIVKALLDNRRSVSYAEIDAPHGHDAFLLDDARYHNLVRAYYERIAEEVGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_SALHS
Sequence: MKAKELREKSVEELNTELLNLLREQFNLRMQAASGQLQQSHLLKQVRRDVARVKTLLTEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: PEX2_PODAS
Sequence: MSDSKPPKDSSSPSAAVPDVAAAAASSTPTPAPVAITPPSNPQSAHSFAQAQQRLIARRQTRDAQEAARVAAQQSESQLRARIAASQSPLLRRLGASTLSLWDTISSREGTRPAFRVGQVDAELLDEELVELMKGQVGEAVRYYGGGGGGDNNIKHEWDAEISLALRAVIFKLTIWDHDATYGAALQNLKYTDARHTGSVLVPPSKWQKGLYGLMTVGGRYMWSKWENWLREQDGGYDEPSPTVQRLSSMTDRLSTLHAAASFASFLVFLLQGRYRTLLDRVLRMRLAPPTSQVSREVSFEYLNRQLVWHAFTEFLLFVLPLVGINRWRRWLARTWRKTKKIMSTTGGEGAEEKKGEFAFLPERTCAICYQDQNQATNENELMAAATSKTGVVGSAQTDVTNPYETIPCGCVYCFVCLATRIEREEGEGWNCLRCGELVKECKPWSGDVLEHESKSPAQKTVVFADDVKDASDDEQENSQVLVQQEDDDEYPEEEGEEGGEEEEEEEEGSRSLEDLRTESASEESSEQEADSEGDESEDYEAEEEELGADLDED
What is the function of this protein?
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity).  The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity).  PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity).  PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-6', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity).  Involved in caryogamy (nuclear fusion), a process required for sexual sporulation (PubMed:7600573).
What are the official names of this protein?
Peroxisomal biogenesis factor 2, Peroxin-2, Peroxisomal protein CAR1.
What is the protein family that this protein belongs to?
Belongs to the pex2/pex10/pex12 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: PYRR_HALH5
Sequence: MSRLILDEQAIRRATTRIAHEIIERNKGVSDCLLVGIKTRGIYLANRLQERIETIEGIKLPVGEVDITLYRDDLTVKSTTEEPILQGTDVPVDVTGKKVILIDDVLYTGRTVRAALDALMDLGRPEQIQLAVLIDRGHRELPIRPDYVGKNVPTSKQEQIVAKLSEVDGIDEVTIEQKTS
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: SAT_BACHK
Sequence: MSTVNELVNRVDETYDVLQIEKEIVLDNIALSDLELLATGGYSPLTGFLRKKDYDSVVETLRLANGSVWSIPITLPVTEEVAETLKVGEEVKLVNGGNVYGVIQIEDIFVPDKEKEALLVYKTTDEAHPGVKKLYERPNVYVGGAIVLTKRFENNPFPSYHLDPIETREEFKKRGWKTVVGFQTRNPVHRAHEYIQKSALEIVDGLFLNPLVGETKSDDIPADVRMESYEVLLQNYYPKDRVFLSVFPAAMRYAGPREAIFHALVRKNFGCTHFIVGRDHAGVGDYYGTYEAQEIFTNFTVEELGITPLFFEHSFYCTKCEAMASTKTCPHGKEDHVILSGTKVRELLRNGEIPPSTFSRKEVVEVLIKGLKKEVVTE
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
Protein: RS19_SYNR3
Sequence: MGRSLKKGPFVADSLLRKVEKLNAAGEKPVIKTWSRASTILPMMIGHTIAVHNGKAHVPVFVTEQMVGHKLGEFAPTRTFKGHIKDKKGGR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: COBT_FUSNN
Sequence: MKDKNCLFDLINKIESIDNVSIKKAQTELDRKMKPKDSLGVLEDICKKTAGIYGYPLKKLEKKCHIVVAADNGIIEEGVSSCPIEYTSIVSEAMLNQIACIGIFTKTLGIDLNVVDIGMKNDIKRNYPNLIHKKIRRGTNNFYKERAMSINECLEAIFTGIDIINEKSKDYDMFSNGEMGIANTTTSSALLYSVTRQNIDDIVGRGGGLSDEGLNKKKKVIIEACERYNTFEMDAVEMLASVGGFDLACMLGIYVGAALNKKLILVDGFISSVAALLACSLNKNIQDYLLFTHKSEEPGVNIILDYLKEKTFLNMNMRLGEGTGAVLACPIIDCAIEMINTMKSPEEVYNLFNK
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: SYP_CUPPJ
Sequence: MKASQFFISTLKEAPADAEIVSHKLMMRAGMIKKLGAGIYNYMPVGLRVIRKVENIVREEMNRAGAVELSMPVIQPAELWQETGRWDKMGPELLRLKDRHERDFAVQPTSEEVVTDIARSEIRSYKQLPVNFYQIQTKFRDERRPRFGIMRGREFTMKDAYSFDRDAEGLKKSYENMYDAYVRIFQRFGLEFRAVAADNGAIGGSGSHEFHVIADTGEDAIVYCPTSDYAANMEAAEALPLVAERAAPTQALEKTFTPEKVKCEQVAEFLGIPLERNVKSIVLAKDTEAGAEIWLLLIRADHELNEVKASKVPGLADFRFATENEIVDAFGSPPGYLGPIDMKKPVKVVADRTVANMSDFCCGANYRDYHFTGVNWGRDLPEPIVADLRNVVAGDASPDGKGTLEICRGIEVGHVFMLGTRYSESMNATFLDENGKTQPMQMGCYGIGVTRILGAAIEQNFDERGIIWPAAIAPFEVVVCPVGYDRSEAVKAEADRIHAELLAAGVDVIIDDRGERPGVMFADWELIGVPHRVVVGDRGLKEGKVEYQGRRDAQATQVAVADVVGHVRGQIGK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAG2D_AGEOR
Sequence: MRAIIYLLLISAMVFSMTKAVPEEEGLQLSEDERGGCLPHNRFCNALSGPRCCSGLKCKELSIYDSRCLG
What is the function of this protein?
Insect active toxin causing rapid but reversible paralysis in crickets.  No activity shown in mammals.  Does not show effect on mammalian voltage-gated calcium channels (By similarity).
What are the official names of this protein?
U2-agatoxin-Ao1d, U2-AGTX-Ao1d, Agel_03.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 01 (U2-agtx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: YJDM_ECOLI
Sequence: MSLPHCPKCNSEYTYEDNGMYICPECAYEWNDAEPAQESDELIVKDANGNLLADGDSVTIIKDLKVKGSSSMLKIGTKVKNIRLVEGDHNIDCKIDGFGPMKLKSEFVKKN
What are the official names of this protein?
Protein YjdM.
What is the protein family that this protein belongs to?
Belongs to the YjdM family.
Protein: TRMB_ASPOR
Sequence: MSTPPAKRQKRDQYRKRAAAAANEDTGKVKLPQKKFYRQRAHANPFSDHQLDYPLSPAHMDWSSHYPAFVNPDPEQKNLAGARKLLKDVEVVDIGCGFGGLLVGLAPLLPETLMLGMEIRTQVIEYVENRIQALRTQQNQLKNSSTTASESPAPAIPAEPATDGASPDAASTPETSNSPVPGGYQNISALRSNTMKFFPNFFGKQQLSKIFICFPDPHFKAKKHKARIISENLNAEYAYALKPGGLLYTITDVEEYHHWVLRHFREEGEHEASEGGVKDLFERVSEEELASDPCVEVMRESTEEGKKVTRNKGNKYVAVFRRKADPEWPA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, Transfer RNA methyltransferase 8, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPA_LAWIP
Sequence: MGQIQFQGAITALVTPFKKGEIDLECYREIIEWQIEQGINGLVSCGTTGESATLTYEEYKLLIKACVEQTKSRVPVIAGAGSNDTAKAIQLTKIAKELGADGVLHVTPYYNKPTQEGLFQHFKTIASQESIPILLYNVPGRTGCNLLPETVARIVQDIPEVVGIKDATGNLEQFSEIIEFCPIGFQVLTGDDFTILPSMILGGCGVISVISNIVPAMVVELCSLIEKNKLEEARQIHYNLAPLCRLMFVETNPIPVKTALSLMEKLELEFRLPLTELSPINFTKLESTLKNIGIISK
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.