PharMolix/UniProtQA huggingface dataset:
Protein: TVB74_HUMAN
Sequence: MGTRLLCWVVLGFLGTDHTGAGVSQSPRYKVAKRGRDVALRCDSISGHVTLYWYRQTLGQGSEVLTYSQSDAQRDKSGRPSGRFSAERPERSVSTLKIQRTEQGDSAVYLCASSL
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 7-4.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RNPH_FRATW
Sequence: MRPSGRNNDQLRNLKVTHNFTKHAEGSVLIEFGDTKVICTASVVAGVPKFKKDSGEGWLTAEYGMLPRSTHTRMDREAARGKQSGRTQEIQRLIGRALRASVDLTAIGENTIKVDCDVIQADGGTRTASITGASLAIADAIEYMKQNGMLDEQANPLLSQVAAISVGIYNNEPVLDLDYDEDSNAETDMNVVMNSNGGIIEIQGTAEGKDFSEEEFAKMLGLAKKGIKEIFATVF
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: BIOB_VIBC3
Sequence: MEVRHNWTVAEVKALLDKPFMDLLFEAQQVHRLHHPHNHVQVSTLLSIKTGACPEDCKYCPQSAHYRTDVDKERLMEVERVLDAAQKAKNSGSTRFCMGAAWKNPKERDMPLLKEMIRGVKDMGLETCMTLGMLTPDQAQQLAQAGLDYYNHNLDTSPEFYGNIITTRTYQDRLDTLSHVRDAGMKICSGGIIGMGESTNDRAGLLVELANLPTHPESVPINMLVKVKGTPLEQVDDVEPFDFVRLIAVARIMMPKSAVRLSAGREKMNEQMQALCFMAGANSIFYGCKLLTTPNPAEDSDMLLFKKLGINREQVAQKPDEITENELLDRVVERVAARPTASDLFYDAAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: SYR_POLSJ
Sequence: MLQIKQDLLDALGQALKTMAPDSGVAAVFESPKVAAHGDFASTAAMQLAKPLKLNPRQVAENLRGLLLQAPAFARWVDAIEIAGPGFLNIRLKPEAKQQVVREVLQGADQYGMQLADSPHRMVVEFVSANPTGPLHVGHGRQAALGDAICNLFDTQGWDVWREFYYNDAGVQIQTLATSTQARAKGLKPGDAGWPEPAYNGDYIADIANDFLAKKTVKSDDREFTASGDVEDIDAIRQFAVAYLRHEQDLDLRAFSVRFDNYYLESSLYSSGRVDSAVQKLKDAGKTYEQDGALWLKSTDYGDDKDRVMKKGDGSYTYFVPDVAYHLAKWERGFSKAINIQGMDHHGTIARVRAGLQAASAGIPQGYPDYVLHTMVRVVRHGEEVKISKRAGSYVTLRDLIEWTSADAVRFFLLSRKPDTEYVFDIDLALAKNNENPVYYVQYAHARICSILGTWAAQGGDASQLKSVDLSALDGPQAQALMLLLAKYPDMLSNAAAGLAPHDVAFYLRELAACYHSYYDAERILVDDEAIKLARLALVAATAQVLHNGLKVLGVSAPHKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURF6_DICDI
Sequence: MSDLKSRLKETSNWMSSMFNIIKDPTSESASFSNRVNSVAPPPRRSSSSSSISFSELTNSNENKTTTTTTTTTTSTTATTSQPPQKSPVEQNKEELKKLLQQQLAEMKLKRQGKNSNINDSNNSNNNNNNTDKNKNDNKKEIIKNKKIKEEEESEGEEVEEEEEEESDISDSEDNNSSNNNGSLNGDYDDYGDEISESGSEMDLINNKNLNKEKRKKQEEDLQFSTFDFSSGKAMPTYLMNKGRKTSKKELLEKAEEKERILANSKRNGTNKELADTIRWSTAFDKVQGIKVKDDPALLRKSIKKVEKTKLKSAREWVQRKKEKDEKLKVRIAKREANIKAKIEEKKERRMGIKKKKTNNNNNKSGGGGGNSHASRQRAGFEGKKKFHFNPKKLIN
What is the function of this protein?
Involved in a nucleolar function.
What are the official names of this protein?
Surfeit locus protein 6 homolog.
What is the protein family that this protein belongs to?
Belongs to the SURF6 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PLSY_YERPN
Sequence: MSAIALGMIIFAYLCGSISSAILVCRVARLPDPRTHGSGNPGATNVLRIGGRTAAVAVLLFDILKGMLPVWIAYLLHIPPLYLGLTAIAACLGHIYPVFFHFKGGKGVATAFGAIAPIGWDLTGLMTGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVAMLSCLILMRHHDNIQRLWRGKEGKIWDKLRKKKQKTPAEEAAELEEKED
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FNTB_DICDI
Sequence: MSSIEEIDTDETFTSDYVSARKDEVDDIITATTIAQKKMENSILEKLNSTENGNIIEKKKILNFLMNGIEKIPMSHQGLDSSKVWISFWILNGMDMLDSLDSYPNISSRASKYLSILQNDDNNGNNNNRENNQNGGGFGGGNSHTSHVVSTFAAVSALYVIGTEESYKTIDREAMYKFLMRMKTKEGAFTSEDGGEYDSRTTYCAIAVASMLNILTAELERGVVDFLLSCQTYEGGFGAYPFNEAHGGYTFCSVAALSILNSLHKIDMNSLHRWITYRQSNDGGFEGRTNKLVDTCYSYWQGAVYIIIQSYFNYYKKQQQDDGDGKEGDQQEEGLLFNQAKLQEYVIRFCQQSDKKYSGFSDHPHRGKDYYHTCYGLSGISLSQYNEIGKAIQSLNTFTNTFEQPSPPINKKSTNVFTISNNNNNNNNKNNNSDDNNNNSNNNNNNSENQLVEPVHPIYNIKLSKCEKGFEIDLFLFQKEFKDASVSLGTLFFYAKFILK
What is the function of this protein?
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins.  The beta subunit is responsible for peptide-binding (By similarity).
What are the official names of this protein?
Protein farnesyltransferase subunit beta, FTase-beta, CAAX farnesyltransferase subunit beta, Ras proteins prenyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the protein prenyltransferase subunit beta family.
Protein: TBB_PNECA
Sequence: MREIVHLQTGQCGNQIGASFWSTISGEHGLDSTGVYQGTSDLQLERMNVYFNEASGGKYVPRSILIDLEPGTMDAVRSGPFGNLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRREAEACDCLQGFQITHSLGGGTGAGMGTLLISKIREEYPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLPDPGYGDLNHLVSAVMSGITTCLRFPGQLNSDLRKLAVNMVPFPRLHFFIVGFAPLTSKGSHSFRSLTVPELTQQMFDAKNMMAASDPRHGRYLTVAAIFRGRVSMKEVEDQMHSVQQKNSSYFVEWIPNNVQTALCSIPPRGLKMSSTFIGNSTSIQELFKRVGDQFSAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYEIAGVDEEVELDDEIET
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: HLDE_PSET1
Sequence: MDLSLLKNLSAARILVVGDVMLDRYWYGDSGRISPEAPVPVVKVSKLEDKAGGAANVAKNIARLDGKVGLLGLIGEDEGGQILEGILEGEKINSQLVSVCDLPTISKMRVISRHQQVVRLDLEETFTEQHSQLLLNRLELVLDEYDFIVFSDYNKGSLSLIENMISLAKKAGKTVLVDPKSSDLHLYRGADYITPNLNEFKLAGGQTDSEEGLATSARKLISDAGIKAMLLTRSEQGMSLISATEKYDFAAQELEVSDVTGAGDTVIATLAVMLGAGMTPKNAVEIANLAAGIAVSKLGAATVSPEELSRKLGQYLHATGEHYQTPFDDVLQHIEFAKQNGETIVFTNGCFDILHAGHVRYLAQAKARGDRLVVGLNNDASISRLKGADRPINPLDERAMVLSALSSVDWVIPFGSADENDTPAKLIEQISPDILVKGGDYTVEQIAGAEHVLLHGGKVEVLEFLDGCSTSKVISKIKQ
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: RPOB_XYLFT
Sequence: MKDLMTSYSFTEKKRIRKDFGKHRSILKVPFLLAIQVDSYRAFLQGDVESSQRKDIGLHGALKSVFPIVSYSGNAALEYVGYKLGEPMFDERECRQRGMSYGAPLRVTVRLVIYDRESSTKAVKYIKEQEVYLGEIPLMTENGTFIVNGTERVIVSQLHRSPGVFFDHDRGKTHSSGKLLYSARIIPCRGSWLDFEFDPKDALFTRIDRRRKLPVSILLRALGYSNEEILGEFFEINTFHINPDEGVQLELVPERLRGEILSFNLTDGGSVIVEAGKRITARHVKQLEASGISALAVPDEYLIGRILSHDVIDATTGELLASANSEVNEDRIIAFRKAGIESVGTLWVNDLDRGAYLSNTLRIDPTRTQLEAQVEIYRMMRPGEPPTKEAAQNLFHNLFFTFDRYDLSMVGRMKFNRRVGRKEVAGEPVLYDKKYFSDRNDEESRRLVSKLGETSDILDVIKGLCEIRNGRGVVDDIDHLGNRRVRSVGEMAENVFRVGLVRVERAVKERLSMAESEGLTPQELINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHLSHYGCLCTIETPEGPNIGLINSLAVFARTNQYGFLETPYRKVVEGRVTDEVEYLSAIEENQYVIAQANTLTDDNGQLTESFVPCRFQGESLLKPPSYVHYMDVSPMQTVSVAAALVPFLEHDDANRALMGANMQRQAVPTLRAQKPLVGTGIERTVARDSGVTVNARRGGVIDQVDAGRIVVKVNESEIIGATDAGVDIYGLIKYTRSNQNTCINQRPLVNVGDIVASGDVLADGPSTDIGELALGQNMLIAFMPWNGYNFEDSILLSERVVEEDRYTTIHIEELTCIARDTKLGSEEISADIPNVSEQALNRLDESGVVYIGAEVRAGDILVGKVTPKGESQLTPEEKLLRAIFGEKASDVKDSSLRVPPGMDGTVIDVQVFTRDGIEKDKRAHQIEEYEIKRVKKDFDDQFRILEGAIYARLRSQIVGKVVNSGVDIKKGEVITDPYLDGLKKSDWFALRMKDEVAVEAIDRAQKQIQAYQKEFDQRFSDKRSKITQGDDLAPGVLKMVKVFLAVKRCIQCGDKMAGRHGNKGVISNVVPVEDMPFMEDGTPVDIVLNPLGVPSRMNIGQILEVHLGWAAKGLGHRIQRMLEANAAIADLRKFLNEIYNHDKSLVGERVDLSQFSDDELLNMAKNLTDGVPMASPVFDGASEQEIKRMLDLAELPAGGQTQLYDGHTGEPFDRKTTVGYMHYLKLNHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVQGRNQMYKNIVDGDHQMVAGMPESFNVLVKEIRSLAINIELEDN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: ATPA_DICCI
Sequence: MQLERILTETNIERSKFKQYKVLSKYINAVAKKYTLNNVSNKYGKVLFIKDGVVKVSGLSQIKIGEKVEFVGKNLFGMALNLEATSVGIVIFGEDTAIYEGVIVKRCEQNFAIKVDKTMLGRVVDVLGQPIDGLGELKDTKTTRVMSVERKAPGIVTRKSVHESMLTGVKMVDALLPIGRGQRELIIGDRQTGKSAIAVDAILNQQVNKDIVCIYVAVGQKKSTVRRLVEMLNTKGALEYTIVVVSTASDAAPLQFLAPYTGCTIGEYFRDEGKHALIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKLNEKYGCGSLTAFPIVETQAGDVSAYIPTNIISITDGQIFLEKELFNKGIRPAVNVGLSVSRVGSAAQSAVMKKLAGALKLELAQYRELARFEQFSSNADAVTTQILKKGKLTIELLKQVNNNPMAVGMEALMIFAMSTSYFQNLDLSLVRAEEAKLLQYIHSVSSFKLYAACVDAVKAFNPKDTVFTEMCQSYVK
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Subunits alpha and beta form the catalytic core in F(1).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.  Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
What are the official names of this protein?
ATP synthase subunit alpha, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: TRUA_NEOSM
Sequence: MRYKAIVEYVGTGFSGWQKQMSAPSVQEELESVLSFLLKEKIAVNVAGRTDAGVHALGQVFHFDARESTLQPFQIVNAVNYHLKEKLIVLLKIEIVDETFDARFSAIRRHYQYKITNRKTPLAVFKNRSWHVPQTLNLDLIREQAQYLVGKHDFQSFRSSKCGASNAIRTLDRLEVEKNGEEMIFHASAKSFLHHQVRIMVGTLVAIASGKLMSVTEILSKKNRRYAGPTAPPCGLYLLKVDY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: Y1824_MYCTU
Sequence: MGSDTAWSPARMIGIAALAVGIVLGLVFHPGVPEVIQPYLPIAVVAALDAVFGGLRAYLERIFDPKVFVVSFVFNVLVAALIVYVGDQLGVGTQLSTAIIVVLGIRIFGNTAALRRRLFGA
What are the official names of this protein?
Uncharacterized protein Rv1824.
What is the protein family that this protein belongs to?
Belongs to the sbp family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FSCB_BOVIN
Sequence: MEEKDESEQSISAGRQEIRKRRRPSQPMVDKSQQTEVTEKKKQLSIPQSSGPKAALSIGNIPGSKLNYECHRVSSQLQQTWIKRKRVQDMADKSLQTETIAEEKKEEIKLVCEAVVPEEKPAAVEVGPEFPESVREVEVPPNRYSVQVKIDRSQQTTCTGDWTMMNFPQKEKLDKEQQTYFSESEIVVIGWPTNSFSKSKEGAQKRKSSGNIFLSEHPEFQPTTSSNEEIRRPSISRTVSISPTKKDSPVPLEDEKDVPVEVQPPAAEEISAEEQLPLAETTSEEVPVAVQPPPAEEPPLEAQPSPTEEAPGDEAPAKVEPTPAEEALSEKPPAEEALVEIQPSPVEEAAGDEAPAKVEATSSEETLLKEPLTEVQPPAAEEAPIQDTPELQLSPAVEAPAEEAPAEAEPPPAEEAPAEEAPEVQSPPAEEAPAEEPPEIQSPPAEEAPAEEPPEVQSPPAEEAPAEEAPEVQSPPAEEAPAEEPPEVQSPPAEEVPAGEPPEVQSPPAEEAPAEEAPEVQSPPAEEVPAEEALAEVEPPPAEEAPAGEPSEVQSPPAEEAPAEEAPEVQSPPSEEAPAEEAPEVQSVPAGQAPAEEPLEVQPPPAEDATEEEASEVQSLPTDEAPAEEGLGFQSPPADKAPEEEAPEVQSPPAEEAPAEEPPEVQSLPADEAPAEEATEEVQSPPTEESPAEEAPAELQPPSTEETTSEMVSVEKQPSLTEEPFITPISLEETSAEVLLPPFEQTPADEALVENVSPVDQAPKEADVLVEKLESGNLDDKPKSEEPLERDTIPKDSSGTKNEGVSFEIKGVIHIELE
What is the function of this protein?
May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation.  Inhibits ROPN1 and ROPN1L SUMOylation.  Binds calcium.
What are the official names of this protein?
Fibrous sheath CABYR-binding protein.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Note=Localizes to cortex of the fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.
Protein: MIAB_MYCA1
Sequence: MTCGFSRADRSPYHGPVTSTVARDVSGVRTYQVRTYGCQMNVHDSERLAGLLEAAGYRRAAEGAEVADVVVFNTCAVRENADNKLYGNLSHLAPRKRSNPQMQIAVGGCLAQKDREAVLRRAPWVDVVFGTHNIGSLPTLLERARHNKAAQVEIAEALQQFPSSLPSARESAYAAWVSISVGCNNSCTFCIVPSLRGKEVDRSPDDILAEVRSLVADGVLEVTLLGQNVNAYGVSFADPALPRDRGAFARLLRACGEIDGLERVRFTSPHPAEFTDDVIEAMAQTPNVCPALHMPLQSGSDRVLRAMRRSYRAERYLGIIDRVRAAMPHAAITTDLIVGFPGETEEDFAATLDVVRRARFAAAFTFQYSKRPGTPAAELDGQIPKAVVQERYERLVELQESISLQGNQALVGQTVELLVATGEGRKDSATARMSGRARDGRLVHFAADDRVRPGDLVTTVITGAAPHHLIADAGILSHRRTRAGDAHAPAGARAASVSACPPSGRRRPGPTRWMCLMNDDRNHDDPRLGALRTEIEAAERRVAGGIDPGARGFVVSILVFVLLGSFILPHTGDVRGWDVLFGTHDAGAAAVALPSRVFGWLALVFGVGFSTLALVTRRWALAWIALAGTAIAGAAGMLAIWSRQTVPAGHPGPGWGLIVAWITVLVLIYQWARVVWSRTIVQLAAEEQRRRVAAQQQSTTLLDDLPKPEDPAAGT
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LRC39_RAT
Sequence: MTESVVCTGAVSTVKEVWEERIKKHHEDVKREKEFQQKLVRIWEDRVSLTKLKEKVTREDGRIILRIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDISDLPTELSKLLKLTHLDLSMNQFTTIPLAVLDMPALEWLDMGSNSLQQLPDTLDRMQSLHTLWLQRNEITCLPETIRNMKNLGTLVLSNNKLQDIPGCMEEMTSLRFVNFRDNPLRLEVTLPPSDDVDGEEEQELFGLQFMHAYIQESRRTEDQVNCLTHTPSSTRSDG
What is the function of this protein?
Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress.  May regulate expression of other M-band proteins via an SRF-dependent pathway.  Important for normal contractile function in heart.
What are the official names of this protein?
Leucine-rich repeat-containing protein 39, Myosin-interacting M-band-associated stress-responsive protein, Myomasp.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, M line.
Protein: NUP85_SCHPO
Sequence: MESSDEVDLPVYHLQNAPIENGKLNDWRSKGRTVAFKLHPFLRKGLAYINNKEFDENTLKSDKFEEVESLVYEFSTPSTLIEPNYLLTAWHELWEELQDTYMTPILDSEANLLLLTQFYGKISSLFRSKIIQVLEELQSRINEGEKDCQPVLDSLWEVESAWRCAEAIYFPPSSPYTLSTGILDWVNAYDPQPIADDGLEIMAYRIPYQHPEFWPYVNKTAIRGLFEQTISCLEMSGLTKEWPVLKETVDELIDILRYSPCTHQKRIRSVSDFERRWKLWRSRLANLRHVVKKHRDIDSEVLDDFVVLLDILNGNKEVIMLSCAHWQEYFSALAFLYGPLDCKNPEDISLLYQLATGEDSKFYVNGTIEYEQICVNLCSNEPLNAIKHAYLLDLGLAVHLADLLSKSGHLRDYITEEYPITLREHLILEYGQCVLESRNLWQTSFAYWKCVADSGYQRIKACIPYVPLSDVDAKETALQLCKQLKLRDEAQLVLTHWADELIARNHYGEALIALDNAANYSALNRVTWELFDICIAEKKSFSPDKDELLYELFSSPKACTPTLASIISPAATIHQYFFYLQHKKELNASELLVGLLTMVDFPSSRFPKLLELLHEFLNNPLQSNSTDFKLSLVNVYDCIAVLQDQQSTVKDQQLLLSIHERLSSAISWYFLHLKK
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.
What are the official names of this protein?
Nucleoporin nup85, Nuclear pore protein nup85.
What is the protein family that this protein belongs to?
Belongs to the nucleoporin Nup85 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus, nuclear pore complex. Note=Localizes to the nuclear envelope and spindle pole body.
Protein: TPIP1_HUMAN
Sequence: MGSSSEASFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQTHTPGWVSDPLVLGAQVHGGCRGIEALSVSSGSWSSATVWILTGLGLGLSRPFLPGATVLRDRPLGSAFELSYDQKKAPLRLQ
What is the function of this protein?
May play an important role in mediating p53/TP53-dependent apoptosis.
What are the official names of this protein?
p53-regulated apoptosis-inducing protein 1, p53AIP1.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ARGC_MYCLE
Sequence: MSYAIRVAVVGASGYAGGEILRLLLGHPAYADDRLTIGTLTAAASSGDTLGEHHPHLTPLAHRVLESTELTVLAGHDVVFLGLPHGHSAALAERLGPETLIIDCGADFRLTDAGAWGRFYESPYAGSWPYGLPELPGGRERLQKARRIAVPGCYPTAILLALLPAMAEGLIEPAVTVFAVSGISGAGRAAKTKLLGSEVIGSARAYNIGGTHRHTAEIIQGLRVVTDRAVTVSFTPVLIPTSRGILAACTARTSSSLSKLRTAYEKAYQVEPFVYLMPEGQLPFTGAVIGSNAAHIAVAVDEAAETFIAISAIDNLVKGTAGAAVQSMNLALGWPEAEGLSVVGVAP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTGES_BOVIN
Sequence: MPPSGLELMNGQVLPAFLLCSALLVIKMYVVAVITGQVRLRKKAFANPEDAQRHGGLQYCRNDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVARMHFLVFFLGRMVHTVAYLGKLRAPTRSLAYTLAQLPCASMALQIVWEAARHL
What is the function of this protein?
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway.  Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity).  Plays a key role in inflammation response, fever and pain (By similarity).  Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2.  In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
What are the official names of this protein?
Prostaglandin E synthase, Glutathione peroxidase PTGES, Glutathione transferase PTGES, Microsomal prostaglandin E synthase 1, MPGES-1.
What is the protein family that this protein belongs to?
Belongs to the MAPEG family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cytoplasm, perinuclear region. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment.
Protein: RS10_YERPN
Sequence: MQNQRIRIRLKAFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHKRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: KAPA_YEAST
Sequence: MSTEEQNGGGQKSLDDRQGEESQKGETSERETTATESGNESKSVEKEGGETQEKPKQPHVTYYNEEQYKQFIAQARVTSGKYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEEDINYGVQGEDPYADLFRDF
What are the official names of this protein?
cAMP-dependent protein kinase type 1, PKA 1, CDC25-suppressing protein kinase, PK-25.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RUVC_MAGMM
Sequence: MSSASPIRVIGIDPGSNVTGWGVIDGLGQRQQVVEYGTIRLDGKEPLPMRLHQIHAQLVSLIQRLQPHEMAVEEVFVSQNVQSALKLGHARGAAIVAGAQMGLPIAEYTAMQVKKAVVGYGRAEKNQMQEMMRMLLNLDKKPAQDAADGLAIAMCHLNQRQWHQQTLPAAILGLQRGGRA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.