PharMolix/UniProtQA huggingface dataset:
Protein: ASC8_DIDFA
Sequence: MVLQKLGDAQRILVFGDSTIENKLPVIRALWEASESHPLLKAFLQQAVEIIQEETQKLASHEGSLFLHCIDVLEVAEVYAEADEPDELIASVLALVARFGALVLDLERDDSNKRSVGPVSILGFCTGLLAGAVAACAEDMIKVFDLACEVLAISFRLVVALVRRSKAIEPNAGLWATTFIRISKEELEMQLDDYNLHHGLSQDKKAYIGVSSQSWNSVFAPPSVILHIARQCPILSQISQVPTTAAMAVHASHLSRPDVNWILGSLPGLETPVLPDRLIVSTSTGKPFLAKTLRELIQSIIADISMNILDIDGTIHGICSGLDMTKPVVISAMGPSPNIPALTRRLASGGVQLKTFAVIAGDRPRRVVPRRPSSSGYSS
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of the selective antifungal agent ascochitine, an o-quinone methide that plays a possible protective role against other microbial competitors in nature and is considered to be important for pathogenicity of legume-associated Didymella species (PubMed:31554725).  The pathway probably begins with the synthesis of a keto-aldehyde intermediate by the ascochitine non-reducing polyketide synthase pksAC from successive condensations of 4 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit (Probable).  Release of the keto-aldehyde intermediate is consistent with the presence of the C-terminal reductive release domain (Probable).  The HR-PKS (orf7) probably makes a diketide starter unit which is passed to the non-reducing polyketide synthase pksAC for further extension, producing ascochital and ascochitine (Probable).  The aldehyde dehydrogenase (orf1), the 2-oxoglutarate-dependent dioxygenase (orf3) and the dehydrogenase (orf9) are probably involved in subsequent oxidations of methyl groups to the carboxylic acid of the heterocyclic ring (Probable).  The ascochitine gene cluster also includes a gene encoding a short peptide with a cupin domain (orf2) that is often found in secondary metabolite gene clusters and which function has still to be determined (Probable).
What are the official names of this protein?
Ascochitine biosynthesis cluster protein 8, SAT domain-containing protein.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS9_YERPE
Sequence: MAENQYYGTGRRKSSSARVFLKPGSGKIVINQRSLEVYFGRETARMVVNQPLELVDMVTKFDMYITVKGGGISGQAGAIRHGITRALMEYDESLRGELRKAGFVTRDAREVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: LPLT_SALDC
Sequence: MSESVRTNTSIWSKGMLSVIVAQFLSAFGDNALLFATLALLKAQFYPDWSQPVLQMVFVGAYILFAPFVGQIADSFAKGRVMMVANGLKLAGAAGICLGVNPFVGYTLVGIGAAAYSPAKYGILGELTTGDKLVKANGLMEASTIAAILLGSVAGGVLADWHVIAALVACALAYAGAVAANLFIPKLVAARPGQSWRLSAMTRSFFSACVVLWRNGETRFSLVGTGLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAVGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVAIFSLQHALLPAYALLLLIGMLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGLYSLAVLVGVPAVAIGIGFGVLFALAIAALWIWQRRQASY
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y918_STAAC
Sequence: MAKKAPDVGDYKYGFHDDDVSIFRSERGLTENIVREISNMKNEPEWMLDFRLKSLKLFYKMPMPQWGGDLSELNFDDITYYVKPSEQAERSWDEVPEEIKRTFDKLGIPEAEQKYLAGVSAQYESEVVYHNMEKELEEKGIIFKDTDSALQENEELFKKYFASVVPAADNKFAALNSAVWSGGSFIYVPKNIKLDTPLQAYFRINSENMGQFERTLIIADEGASVHYVEGCTAPVYTTSSLHSAVVEIIVHKDAHVRYTTIQNWANNVYNLVTKRTFVYENGNMEWVDGNLGSKLTMKYPNCVLLGEGAKGSTLSIAFAGKGQVQDAGAKMIHKAPNTSSTIVSKSISKNGGKVIYRGIVHFGRKAKGARSNIECDTLILDNESTSDTIPYNEVFNDQISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAVEMNRLIKFEMEGSIG
What are the official names of this protein?
UPF0051 protein SACOL0918.
What is the protein family that this protein belongs to?
Belongs to the UPF0051 (ycf24) family.
Protein: MURC_CLOBA
Sequence: MSFDFIKDRDKKVHFIGIGGISMSGLAAVLLNSGYKVSGSDFKESEILKKLRLSGADIYIGHSEKNIKDVDLVVYTAAIPENNPELIYAKENNIDLMNRAEFLGNIMKGHKYNVAISGAHGKTTCTSMLSNITLKANLDPTILVGGELDIIGGNFRIGSSDYFITEACEYKRSFLSFFPYVGVILNIDADHLDYYKDIDEITETFGQFADLIPNDGYLIGYIGDSRVKEILSKAKCNTLSYGFENADVTARNITFNEKGCASFDVYKHNDKLFDLTLSNPGEHNILNALSSICVSLIFDVNYDDIICGLSECKGAHKRFEYKGEVNGVTVIDDYAHHPVEIKATLNTSKKIPHNKTFCVFQPHTYTRTKTLFDEFTDAFFDADEVVLMDIYAAREKDTGLVSSNDLGVALRAKGVKCTNVHSHDEALEYLKNSAKPNDLLLTVGAGDVVIVGEKYLNQGK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBLN4_CRIGR
Sequence: MLPFASCLPGSLLLWALLLLLLGAASPQDSEEPDSYTECTDGYEWDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDEQESCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKVGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCNQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECETGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCFCPVSNPLCREQPSSIVHRYMSITSERSVPADVFQIQATSVYPGAYNAFQIRAGNTQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF
What is the function of this protein?
Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta.  In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin.  Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction.  Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling.
What are the official names of this protein?
EGF-containing fibulin-like extracellular matrix protein 2, Fibulin-4, FIBL-4, Protein H411.
What is the protein family that this protein belongs to?
Belongs to the fibulin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, extracellular matrix, basement membrane. Note=Localizes on the microfibrils surrounding ELN cores.
Protein: KCRB_SQUAC
Sequence: AKVLTLDLYKKLRDKSTPSGFTLDDIIQNEHLGYVLTCPSNLGTXLRAXVHV
What is the function of this protein?
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e. g.  creatine phosphate).  Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
What are the official names of this protein?
Creatine kinase B-type, B-CK, Creatine kinase B chain.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
What are the subcellular locations of this protein?
Basal cell membrane. Note=Basal membrane of the sodium chloride-secreting epithelia.
Protein: IRS4_CHAGB
Sequence: MGAGLAPRGANGALLAATQAARGHAAAGGGNKGVNEGGSAAAAVGAGTGSGSGLDGGHGHGGGLVGQRVLDLHAGSGSGGGGSTLLPPPAGRSGADGGGGGGGRKSSPSLIAATLAASRSVSPARGPIPQLDLNGGGGKVTRKRGQSVGAASVIVGSVGPRHEAEVLDTASIPPTTSLVSLFEGKREANDVDPVKKRAPSVRRKDMDTEEQARKERASQEPQKVKPKPVPKPKPKPEVATDVAVPKSSDDAHGASEGTSRLGGTGRSGHGDERGRAEAKPSQRRARSQHSEHKPAKKPKPAQHRPPTPPPSLPTRSPSNHVVSQPKRVAKTPRLEPPTPPVKTSTIAKMAEPIVQVTPVEPDIDQVDVFHHQDRNPKPRQVSQGSTSSNDSFVSASSVPSGAVSPVREVESTPRRPAPPARSPSSRSISTPNPPRQQASHPSTPNLTLSSLTNAMMASNLASARLTPTTPSQPPPLPAPRRSGRSPLQPHHTADSIGSQLTGGSKSPNHAAHQQKQRTGMLQTLRSPHASLSDDEDARRQHHHRRRSKVLSGGNRKHAHHEGSRRRWRDEITARERKRYEAVWASNRGLFLRPGWAAQYQNTTTATTGGASPTQQGHGPGTGEETQHQTRDQAVEASRASHGAEAELVVNVVARDIWSRSRLPADELAEVWDLVDRGARGALGRDEFVVGLWLIDQRLRGRKIPARVSQSVWDSAAGGYQGVVVPLPGGGAGGGGRKGRRA
What is the function of this protein?
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway.  Involved in rDNA silencing (By similarity).
What are the official names of this protein?
Increased rDNA silencing protein 4.
What is the protein family that this protein belongs to?
Belongs to the IRS4 family.
Protein: NAA50_XENTR
Sequence: MKGRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGELAKLAYFNDIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEKDGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVLQKNLKISSPGQNADVQKSEN
What is the function of this protein?
N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine.  Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position.  Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins.  The relevance of N-epsilon-acetyltransferase activity is however unclear.  Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin.
What are the official names of this protein?
N-alpha-acetyltransferase 50, N-acetyltransferase NAT13, N-epsilon-acetyltransferase 50, NatE catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. GNAT subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes to the cytoplasm in interphase cells.
Protein: PYRC_GEOMG
Sequence: MNLLIQGGRVIDPSQGIDEVLDILVENGAVKELGKGVKAPSGTETIDASGLIVTPGLIDMHVHLRDPGHEYKEDIVSGTKAAAAGGFTSVACMPNTKPVNDNKAVTSYIIAKAKAEGSVNVFPVGSITQGSKGELLSEMGELKESGCVAVSDDGHPVTNSELMRRALEYAKGMGIMVISHAEDLSLVGAGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTDSPLHIAHVSTKGSLRIIRNAKARGVKVTCETAPHYFSLTDDAVRGYDTNAKMNPPLRTADDVTAVKEALKDGTIDAIATDHAPHHIDEKDLEFNEALNGIVGLETSLTLSLRLVEEGVLTLPVLVDKMACNPAKILGIDRGTLKPGSVADITVIDPKATWTVDADKLASKSKNSPFLGWEVKGAAAFTIVGGKVVYKR
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: STU1_CHAGB
Sequence: MSEILTDDQVANLIALLRADVSIDTKVQQVTVVKSSIKQHMVPESCIVPVFEALHLASSSQHALLVNAGFTALNHLFTRLVRQDPRSLTKEGTRALPLIVEKLGDQKEKFRQLASQALATLYKVAPVEVERSVRNIAMVGKNARAKEASLHWLLQMHQEQGLQFRAYVPTMMELLEDADGMVRDVAKSTVIELFRNAPGPAKSDLKKQLKNFKVRPAIEQAIVKELNPTSSAPASQPDPESVEPSYVNTTRELDEIFREMHGYFEGKETEQNWLKREESVTKLRRLIAGNAATDFHDQFLTGLRALLDGIIKAVVSLRTSLSKEGCSLIQEIAKAYGPAMDPMVEILMQTFIKLTAATKKIASAQANTTVDTIISKVTYNNRIMQHVWLACQDKNVQPRLYASGWLRTLLAKEAHHKNHVEHTGGLDLIEKCIKKGLSDANPGVREKMRATYWMFAGVWPAKAEAIMNGLDSTAARLLQNDPNNPKSPKKPEGGARPGLGLSKSTMGTSKPSVREAMMAQKRAMTTKTVPTRPGSAMSHFSPAKSVSSLSQPPPAAPTVRARPESAMLGSTGGISGAPMRPGRRKVETARPATAGPYSVRSHDQPSAEQTSPPSRPKPKAVTPKSITSSPKRTAPKMARSATVSGEPQLPTPTRAGSPKVMGSPRATPSRSVPPTVAPPSSSPSKRHEDFSLVVPIMTSSASPPREEQRFVKPVEDEDMDMSPSDTPSKPGQHSPDAPASPPQTVAAVDEEPISITTPLRSVEVAVPSPPSASRSLEVYEDPLTREQLTTPKLIFGPVLEDRSVNEDAAILQQAVRQQQEQQQQQQQQNGAANGMALSPEKLKQNQRLLDSGISKVQQRSLDVHGFRKLQGIIRDSDTKPTTGTALLTDDKFDALVAGLFDFLESPLTNLAPEKTQDVKAQVLATIKLLLKRTRASFQPHVSRGLESLLRARAVYEGRTHIVSGLELLAADLAGLGDASEIVLVLCRMLSDLDVDSAAHAAAGGVGGGAGRSLSMGLHVLREMLDARGAAFVPSDAELAALAALAGGCLESLESAVRMDAVLLCVALHARVGDARFWEALKGVKEDPKSLITYYIVKRQREVGAAGVGQAA
What is the function of this protein?
Microtubule binding protein that promotes the stabilization of dynamic microtubules.  Required for mitotic spindle formation (By similarity).
What are the official names of this protein?
Protein STU1.
What is the protein family that this protein belongs to?
Belongs to the CLASP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.
Protein: TPC2_HUMAN
Sequence: MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWLCR
What is the function of this protein?
(Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC), by endocytosis.
What are the official names of this protein?
Two pore channel protein 2, Two pore calcium channel protein 2.
What is the protein family that this protein belongs to?
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Protein: CDND2_ENTCL
Sequence: MELQPQFNEFLANIRPTDTQKEDWKSGARTLRERLKNFEPLKEIVVSTFLQGSIRRSTAIRPLGDKRPDVDIVVVTNLDHTRMSPTDAMDLFIPFLEKYYPGKWETQGRSFGITLSYVELDLVITAIPESGAEKSHLEQLYKSESVLTVNSLEEQTDWRLNKSWTPNTGWLSESNSAQVEDAPASEWKAHPLVLPDREKNEWGRTHPLAQIRWTAEKNRLCNGHYINLVRAVKWWRQQNSEDLPKYPKGYPLEHLIGNALDNGTTSMAQGLVQLMDTFLSRWAAIYNQKSKPWLSDHGVAEHDVMARLTAEDFCSFYEGIASAAEIARNALASEEPQESAQLWRQLFGSKFPLPGPQGGDRNGGFTTPSKPAEPQKTGRFA
What is the function of this protein?
Protects E. coli against phage T2 infection.  When the cdnD-cap2-cap3-cap4 operon is introduced in E. coli there is a more than 10(3) decrease in the efficiency of T2 plaque formation.  The operon does not protect against phage T5 and only about 10-fold against T7.
What are the official names of this protein?
Cyclic AMP-AMP-GMP synthase, cGAS/DncV-like nucleotidyltransferase, CD-NTase038.
What is the protein family that this protein belongs to?
Belongs to the CD-NTase family. D02 subfamily.
Protein: RL27_SHESA
Sequence: MAHKKAGGSTRNGRDSESKRLGVKRFGGESVLAGNIIVRQRGTKFHAGVNVGIGRDHTLFALTDGKVKFEVKGPNNRKFISIEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: AROB_XANOR
Sequence: MTLPRSSRSVAVDGAQPYTITIAPGLLADDARLARHVRGRHALLLSDSQVAPHYAAGVRAALLSARPDLQIGELVIAAGEASKTLDTFGSAITALAELGATRDACVFALGGGVVGDLAGFAAACWMRGVDCVQLPTSLLAMVDSSVGGKTAVDIPQGKNLVGAFHPPRAVLADTDTLRTLPARELRAGLAEVIKYGAIRDPLFFQWLHAERHALLDSDPAALAQAIARSCEHKAEIVARDPLEKGERALLNLGHTFGHAIETEQGYGAPGNDNLNHGEAVAVGMVLAARLSATLGMSDAQDTEALRALLHDFELPTDIPPGLPPEALLARMRLDKKNIAGRLRLVLWRGIGKAEVVPDVEEAAVLKILAG
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_STRPD
Sequence: MKKTYRVKREKDFQAIFKDGKSTANRKFVIYHLNRGQDHFRVGISVGKKIGNAVTRNAVKRKIRHVIMALGHQLKSEDFVVIARKGVESLEYQELQQNLHHVLKLAQLLEKGFESEEKH
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RL24_BACSH
Sequence: MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKHSKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: DGOD_ECO81
Sequence: MKITKITTYRLPPRWMFLKIETDEGVVGWGEPVIEGRARTVEAAVHELSDYLIGQDPSRINDLWQVMYRAGFYRGGPILMSAIAGIDQALWDIKGKVLNAPVWQLMGGLVRDKIKAYSWVGGDRPADVIDGIKTLREIGFDTFKLNGCEELGLIDNSRAVDAAVNTVAQIREAFGNQIEFGLDFHGRVSAPMAKVLIKELEPYRPLFIEEPVLAEQAEYYPKLAAQTHIPLAAGERMFSRFDFKRVLEAGGISILQPDLSHAGGITECYKIAGMAEAYDVTLAPHCPLGPIALAACLHIDFVSYNAVLQEQSMGIHYNKGAELLDFVKNKEDFSMVGGFFKPLTKPGLGVEIDEAKVIEFSKNAPDWRNPLWRHEDNSVAEW
What is the function of this protein?
Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
What are the official names of this protein?
D-galactonate dehydratase, GalD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: MCMD2_MOUSE
Sequence: METLQMKEAALVYLDRSGGLQKFIDDCKSYNDSKQSYAVYRFSILIDPCDVVELDADLGNHILHHPLKAARVFQSVCFVAVKTLSLIGQLQTETQINIVLKLTHLPALPSYTLDLCEFPLNYASQRFYMMQGIVIAMTTITKYTQGARFLCSDGVCPLSKGFQYVRVHVPGATESATVRNDFLCSLCSSSLQEDRKFRVLGDKQIVEIITTKMFHAFQGDSKNQPFRFQSLGIFLRDELVNKMKIGNEYKIIGIPVCVKTSQTALCVEANNITPHTAKVPLGISDNFRRLLSLTSSSCWKFTAMLANVFASQIVAPGTYNLLKLCLLMSLVQTRDCNREREDCLDILVITSDTLLVDRLLNFSMNLVSRGIRHPVCTEVFPTVSRNKYGTGAVSIQAGSALLAKGGICFIGDLTSHKKDKLEQLQSALESRSVTVFIPGKKFGDDFDQQMTFPIQCSFWSFVDMDSSSRRNVQKTSTLIGQMDCSLIPANLAEAFGLLINCSEASPCHPLLPTVQHTLKKAVEPEGLLYLASKQFTTEDFEKLLAFAKSLNMEFSLEAERMIHGYYLASRRIRTDSIHGSKLSASALKYLVSLSEAHARLSLRTTVLREDALIAALLLEISLTLRYGATPFCVAPNALFPFELYNEEYLEQRDLYLTQCQQQLQQFIATCGPGTTVFSSDE
What is the function of this protein?
Plays an important role in meiotic recombination and associated DNA double-strand break repair.
What are the official names of this protein?
Minichromosome maintenance domain-containing protein 2, MCM domain-containing protein 2.
Protein: YE18_YEAST
Sequence: MMPTYLGKLTWSYFFTTLGLACAYNVTEQMEFDQFKSDYLACLAPEHRNIVVDLASNGFITISPMANATIDFEDVTSDYFNCTDVNTNVQVTIASFYNEYGFGPDDNGYYHAMEEPSEFERHDMDVRLYRPYYPGEFVMGRRSDALGVTGFDQKDCAGEGFYDEQTAATSCQNIGSTQYAKSVRSYNYGCCGGAVWIRIWPHHNCSKGHDHHFKIRPGQMLCWNVNPYSWMQPESGWNP
What are the official names of this protein?
Uncharacterized protein YER188W.
Protein: SERC_ECO45
Sequence: MAQIFNFSSGPAMLPAEVLEQAQQELRDWNGLGTSVMEVSHRGKEFIQVAEEAEKDFRDLLNVPSNYKVLFCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAASAIKEAKKYCTPNVFDAKVTVDGLRAVKPMSEWQLSDNAAYMHYCPNETIDGIAIDETPDFGKDVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIGPAGLTIVIVREDLLGKANIACPSILDYSILNDNDSMFNTPPTFAWYLSGLVFKWLKANGGVAAMDKINQQKAELLYGVIDNSDFYRNDVAKANRSRMNVPFQLADSALDKLFLEESFAAGLHALKGHRVVGGMRASIYNAMPLEGVKALTDFMVEFERRHG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMC4_DANRE
Sequence: MTSSAGQGGGALSTRGGAATKRMKWAVELSLGNSRSRSDRQGKDGDVMYPVGYSDKPVPDTSVQEADRNLVEKRCWDVALGPLKQIPMNLFIMYMSGNTISIFPIMMVCMMAWRPIQALMSMSATFKLLESSSQQWLQGLVYLIGNLLGSALAIYKCQSMGLLPTHSSDWLAFIEPPQRLEIMGGGMVM
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
What are the official names of this protein?
ER membrane protein complex subunit 4, Transmembrane protein 85.
What is the protein family that this protein belongs to?
Belongs to the EMC4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: Y1236_BURVG
Sequence: MTELIRIAALFAVTAVAEIVGCYLPWLVLKGGRPVWLLVPAALSLALFAWLLTLHPSAAGRTYAAYGGVYIGVALLWLRVVDGVALTRWDAAGAALALGGMAMIALQPRA
What are the official names of this protein?
UPF0060 membrane protein Bcep1808_1236.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GATA4_MOUSE
Sequence: MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSAAAAGTTSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYGSGGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPGRHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPAGETLPPSSGASSGNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGPSIHPVLSALKLSPQGYASPVTQTSQASSKQDSWNSLVLADSHGDIITA
What is the function of this protein?
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:35182466).  In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (By similarity).  Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity).  Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).  Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153).  Promotes cardiac myocyte enlargement (By similarity).  Required during testicular development (By similarity).  May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity).
What are the official names of this protein?
Transcription factor GATA-4, GATA-binding factor 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: SLYX_HISS2
Sequence: MPQTQELDQRIAELEMKIAFQENTLEELNQALIDQQFVLDKMQLQLRYMASKLKDLQSSNIASQAEETPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: LUXD1_PHOLE
Sequence: MENTQHSLPIDHVIDIGDNRYIRVWETKPKNKETKRNNTIVIASGFARRMDHFAGLAEYLANNGFRVIRYDSLNHVGLSSGEIKQFSMSVGKHSLLTVIDWLKERNINNIGLIASSLSARIAYEVAAEIDLSFLITAVGVVNLRSTLEKALKYDYLQMEVNTIPEDLIFEGHNLGSKVFVTDCFENNWDSLDSTINKICELDIPFIAFTSDGDDWVCQHEVKHLVSNVKSDKKKIYSLVGSSHDLGENLVVLRNFYQSMTKAAVSLDRQLVELVDEIIEPNFEDLTVITVNERRLKNKIENEIINRLADRVLASV
What is the function of this protein?
Acyl transferase is part of the fatty acid reductase system required for aldehyde biosynthesis; it produces fatty acids for the luminescent reaction.
What are the official names of this protein?
Acyl transferase, ACT, C14ACP-TE, Myristoyl-ACP-specific thioesterase.
What is the protein family that this protein belongs to?
Belongs to the LuxD family.