PharMolix/UniProtQA huggingface dataset:
Protein: ITBP1_MOUSE
Sequence: MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSGQSNSNLDTCAEFRIKYVGAIEKLAVSEGKSLEGPLDLINYIDVAQQDGKLPFVPLEEEFILGVSKYGIKVSTTDQHGVLHRHALYLIIRMVCYDDGLGAGKSLLALKTTDASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSDKS
What is the function of this protein?
Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1.  Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis.  Stimulates cellular proliferation in a fibronectin-dependent manner.  Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner.  Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin.  Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool.  Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin.  Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis.  Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway.  Promotes transcriptional activity of the MYC promoter.
What are the official names of this protein?
Integrin beta-1-binding protein 1, Bodenin.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle. Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in an integrin- dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin- rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen (By similarity).
Protein: CRYD_VIBCH
Sequence: MSKKIGLYWFTNDLRVNDNPLLEQASQQVDRLICLYCYPSITPFLARYAQQTQWGEAKKRFLNQTLADLDHSLSTLGQKLWVTPLLPYQALRHLLTQVEITDIYVDAVAGSDERQAIARIHQDFSSVHIHQQALHSLLSEPQLPFALEALPSTFTQFRKQVETISLSAPMGYPHVLPPIEQGWQLPLMDIVTEPNHSAFVGGEQAGLTHCQNYFSSLLPSRYKETRNGLDGMDYSTKFSPWLALGAVSPKTIYAMLQRYEAVHGANDSTYWIFFELLWREYFYWYARRYGAKLFRFSGIGEKKPLTSFYAQRFLQWKHGETPFPIVNACMRQLNQTGYMSNRGRQLVASCLVHELGLDWRYGAAYFETQLVDYDVGSNWGNWQYLAGVGADPRGSRQFNLEKQAHTYDPKGEFVAKWCGTACDKLNALENLALDSVDMVDWPIAASAYLLIHHPQNKESSS
What is the function of this protein?
May have a photoreceptor function.  Binds DNA; probably functions as a transcriptional repressor (By similarity).  Has no photolyase activity.  Upon purification from either V. cholerae or E. coli an approximately 60 nucleotide RNA is associated with the protein.
What are the official names of this protein?
Cryptochrome DASH.
What is the protein family that this protein belongs to?
Belongs to the DNA photolyase class-1 family.
Protein: SYP_MESFL
Sequence: MKQLEKITPRDVDFSQWYTDTVINAKLASYGPVKGTIIFRPYGYAIWELIQKYLDAKFKELEVQNVYFPLLIPQSLFQKEKDHIEGFSPEIATVTRVGDTPLPEPLFIRPTSEVLMANFFKNEVKSYRDLPLIFNQWTNVMRWEKTTRPFLRTSEFLWQEGHTVHSERKEASDLTLKILDTYTEFAQNALLLPVIPGKKTEKEKFAGADSTYTIESLMHDGQALQCGTSHYFADNFSKPYEIKFQNKEGKLEHAYSTSWGVSTRLIGAIIMTHSDDNGLVLPSMVSPVQVRLIQIKETDEVIKVTEDIKEALKNKYRVDIDKTDKSFGFKISEAEIKGIPLRIEIGPRDLENNQVTISRRDTREKIQVNVNEVTNIVDQMIKEYDANLYAKALKNREERTSRANSIEEYKNILAQNQGFVLVPFCGEIECEDDVKKQTSTNSRCIPFDQDNKTEKCFNCNKDTTLKVYFARAY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_SHEPC
Sequence: MSLDISQFPVLAQANTPNELRQLPQALLPQVADELREFLLKSVGMSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKMHTIRQKNGLHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLVVLNDNEMSISENVGALNNHLAQLMSGRFYTTLREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPGTLFEELGFNYIGPIDGHDVDALVETMRNMRNLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPTQFKKPSTTPGLPTFSQVFGKWLCDIAEQDDKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGYKPVVAIYSTFLQRGYDQLIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYNAGPSAVRYPRGSATGATQVEAMTALPIGKGVIKRVGKRIALLNFGTTLASALTAADNLDATVVDMRFVKPLDAELVTEMAQTHDILVTVEENAIMGGAGSGVLELLQKLKMPKPVLQIGLPDEFIKHGSPEEVTHDLQLDAEGILAQINAYLAQ
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: RL30_LEPBA
Sequence: MEEVIVTQDRSSIGIIPMHKKTLIALGLKKKGQSKKHKMTPQLKGMLRQVGYLLKVEKV
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: PYRG_METAC
Sequence: MKYIVVTGGVMSGLGKGITIASIGRNLKNKGYKVTAIKIDPYINIDAGTMSPYQHGEVFVLRDGGEVDLDLGNYERFLDTELTRDHNLTTGKIYQEVIAKERRGDYLGKTVQIIPHITNEIKSRIRKVAARSGADVCLVEIGGTVGDIESMPFLEAVRQMHREEPSENIVFIHVTLVMEDLQGEQKTKPSQHSVKELRALGLSPEVIVTRSKTPLQESAKEKIALFCDVPQELVISAHDAADIYEVPLEIEEQGLTTRLMKHLKLESSVEDNGWREMVSRMKSTTEEVKLAIVGKYTNLEDSYLSILEAVKHGGIDNGCKVEVNMVEAETLEEDPAEIEKLRQFDGILIPGGFGGRGTEGKMLAIKFARENDVPFLGICLGMQLAVIEFARNVVNLENANSTEFDEDTPYPVIDILPEQTGVADMGGTMRLGDYDAILKDGSLATKLYGTNYIVERHRHRYEVNPEFVDRLESFGIVFSGKNKNRMEIAEIPDKRFFFASQFHPEFRSRPGRPSPPFKGLVRAMCKYNKEKEGQ
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: RL13_BRUA2
Sequence: MATFSQKPAEVVKKWVLIDAEGLVVGRLASLVANRLRGKHKATFTPHVDDGDNVIIINADKVVLTGKKYTDKKYYWHTGHPGGIKERTARQILEGRFPERVLEKAIERMIPRGPLGRRQMKNLRVNAGPNHQHEAQQPEVLDVAALNRKNKGNA
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: CYSG_ACIAD
Sequence: MEIFPISLKLQQQRCLIVGGGHIAYRKAILLVKAGAILDIVAPDIDPQLMSLIEQSAGTAYVKLFEDHDLDRVYRLVIAATDNADVNKRVFEQAELRNLLVNSVDDIPNCRFMVPAIIDRSPLLISVASNGASPVLSRQLRTQIETLVPHGMGKLAEFSGQWRSRVKAQITNPDERRIFWEELYASPLKEQVFNDNLDIANQMMTQSLAEWTAPKGEVYLVGAGPGDPELLTLKALRLMQQADVVIYDRLVSAPILELCRRDAEKVYVGKARSNHSVPQEGINALLVKYAQAGKRVCRLKGGDPFIFGRGGEEIQELFAAGIPFQVVPGITAASGCSAYAGIPLTHRDYAQSVRFLTGHLKEGSPELPWSELVYENQTLVLYMGLVGLEHICQQLIAHGQRPDMPVALVSKGTTPEQKVVVGTLSNIASKIAEYQIHAPTLTIIGEVVSLREQLQWL
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: SECF_DICTD
Sequence: MKKEINFLGKRVRRVFMILSLLFVIIGMYFFFTKGLNYSIDFQSGSVIYYKLSSPLNSNQIANLRDIARSFYSKSTIQTGSNGKEVWIRTKFLEENELKRLTSEVEKVIVKYEGREITTIEPTISRELREKAILAAVLAIIVMLVYITVRFRFDFAISAIINEAFVLLATISIFAISQWEVSPSFIAAILTLLGYAINDNIIVFDRIRENSKKYPKEDFTIIANRSINQTLARTLYTVITTLLAITPLLIWGGVVLRPFILAIYLGIIIGTYSTIYIASAILCEWRELQK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecF.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NCAP_I89A3
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTVERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYKRVGGRWMRELVLYDKEEIRRIWRQANNGDDATRGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGIGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFSARSALILRGSVAHKSCLPACVYGPAVSSGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRLLSFIRGTKVSPRGKLSTRGVQIASNENMDNMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFEKSTVMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEVSFRGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RHAM_SALPB
Sequence: MIRKAFVMQVNADAHEEYQRRHNPIWPELEAVLKSHGAHHYAIYLDQERNLLFATVEIESEERWNAVASTDVCQRWWKHMRDVMPANPDNSPVSAELKEVFYLQ
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPX6_RAT
Sequence: MTQQFWGPCLFSLFMAVLAQETLDPQKSKVDCNKGVAGTVYEYGANTLDGGEYVQFQQYAGKHILFVNVASFCGLTATYPELNTLQEELRPFNVSVLGFPCNQFGKQEPGKNSEILLGLKYVRPGGGFVPNFQLFEKGDVNGDNEQKVFSFLKSSCPPTSELLGSPEHLFWDPMKVHDIRWNFEKFLVGPDGAPVMRWFHQTPVRVVQSDIMEYLNQTRTQ
What are the official names of this protein?
Glutathione peroxidase 6, GPx-6, GSHPx-6, Odorant-metabolizing protein RY2D1.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMN_ALIB4
Sequence: MAKEALPSIYDYTLDELKEILKPSFRAKQVYNWLYKKYASSYDEMKNLPKELVEDLKENYPIDIMQIVKKEQSRDGSIKYLFKLRDNHTVEAVLLLMKDKKIDEDGQIVRSEKYTVCISSQVGCKVGCSFCLTAKGGFVRNLTVGEYIAQIVNIKRDNDIAENKALNIVYMGMGEPLDNFDNFTKAVEIFSELDGLAISRRRQTVSTSGIATKIKKLGEKDLQIQLAISLHAVDDELRSELIPMNKAYNIASIIQAVKAFPVDTRKKVMFEYLVIKDKNDSIEAAKKLVSLLNGIQAKVNLIYFNPYPGTSYQRPQEKDMLKFKDFLNQKGVICTIRESKGLDISAACGQLKEKEANGNS
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUON_ECO24
Sequence: MTITPQNLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGAMDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNKDEFYLLVLIAALGGILLANANHLASLFLGIELISLPLFGLVGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQSGDLSFVALGKNLGDGMLNEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVSTFLATASKIAIFGVVMRLFLYAPVGDSEAIRVVLAIIAFASIIFGNLMALSQTNIKRLLGYSSISHLGYLLVALIALQTGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPYRGPDADSLFSYRGLFWHRPILAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQAHLWWLVGAVVVGSAIGLYYYLRVAVSLYLHAPEQPGRDAPSNWQYSAGGIVVLISALLVLVLGVWPQPLISIVRLAMPLM
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PFDB_SULIK
Sequence: MAEKLPPEVQAQLAKFQQLKDQLDRLLLEKSTIENELREINKVLEELSVLNADATIYKIVGNLLVKSDKTSVEKELNDRKELLELRSRTYQKQESILRKQLEDLQAKINEMLSKYYPQGGQTGIKA
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA1_HAHCH
Sequence: MQDHASSKDDRALQRTRHWISGYSPDVRIQERGVLVSVGDGVAWIKGLPSARMEELLDFEDGSLGMVFDLCEELVGAVILQQTGSLTAGQEVHRTRRPLGLLAHDSLLGRVIDPTGRPLDGQSPLHEGAWVNLNSPTPAIVERDFVHEPLYTGIRMIDAMIPIGRGQRQLIIGDEGLGRTSIALNAVLHQKDKDVRCIYVLIGQKRGAAVNVMQTLQRHGADAYTTLVVADAGSPPGLQYLAPFAGSALASHWMRQGRHVLMVYDDLSSHARSYRELSLLLRRPPGREAYPGDVFSVHARLLEQATCLSPEQGGGSLTALPIAETQQGEIAAYIPTNLISITDGQIYLERSLFAAGVRPAIDVGRSVSRIGGKAQHPAIKHEAIRMKLDYSRFLELEIFTRFGAKLDPGMQTVIKRGQLLRELLKQDRFERFSPEQELAWMIAYNEGLLDEHPLTDIPAALLQIQSRLDARLSLETPREDWTAALQKMLTTADV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 1, ATP synthase F1 sector subunit alpha 1, F-ATPase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: POL4_DROME
Sequence: QQSEQLQQKQCQCTSNPRTGQLATAFRYSVEEDRRVYTINYNLNIFSTFIHAKTGVKLVFLLDTGADISILKENSDKFSNIQITNKINIQGIGQQKIQSRGQTFIEIQTGKYVIPHDFHLVDKNFPIPCDGIIGIDFIKKYNCQIDLNQEEDWFIIRPNNLKFPIYIPIAYSSGINTTLLPARSQVVRRLIVSSKDDNILIPNQEIQTGIYVANTIATSSNTFVRILNTTDSDQLVNMDTLKYEPLSNYNVVQANSEHRNKTVLSQLKKNFPELFKSQLENICSEYIDIFALESEPITVNNLYKQQLRLKDDEPVYTKNYRSPHSQVEEIQAQVQKLIKDKIVEPSVSQYNSPLLLVPKKSSPNSDKKKWRLVIDYRQINKKLLADKFPLPRIDDILDQLGRAKYFSCLDLMSGFHQIELDEGSRDITSFSTSNGSYRFTRLPFGLKIAPNSFQRMMTIAFSGIEPSQAFLYMDDLIVIGCSEKHMLKNLTEVFGKCREYNLKLHPEKCSFFMHEVTFLGHKCTDKGILPDDKKYDVIQNYPVPHDADSARRFVAFCNYYRRFIKNFADYSRHITRLCKKNVPFEWTDECQKAFIHLKSQLINPTLLQYPDFSKEFCITTDASKQACGAVLTQNHNGHQLPVAYASRAFTKGESNKSTTEQELAAIHWAIIHFRPYIYGKHFTVKTDHRPLTYLFSMVNPSSKLTRIRLELEEYNFTVEYLKGKDNHVADALSRITIKELKDITGNILKVTTRFQSRQKSCAGKEQLDLQKQTKEIASEPNVYEVITNDEVRKVVTLQLNDSICLFKHGKKIIARYDVGDLYTNGILDLDQFLQRLELQAGIYDISQIKMAPWKKIFEHVSIDKFKNMGNKILKNLKVALLNPVTQINNEKEKEAILSTLHDDPIQGGHTGITKTLAKVKRHYYWKNMSKYIKEYVRKCQKCQKAKTTKHTKTPMTITETPEHAFDRVVVDTIGPLPKSENGNEYAVTLICDLTKYLVAIPIANKSAKTVAKAIFESFILKYGPMKTFITDMGTEYKNSIITDLCKYLKIKNITSTAHHHQTVGVVERSHRTLNEYIRSYISTDKTDWDVWLQYFVYCFNTTQSMVHNYCPYELVFGRTSNLPKHFNKLHSIEPIYNIDDYAKESKYRLEVAYARARKLLEAHKEKNKENYDLKVKDIELEVGDKVLLRNEVGHKLDFKYTGPYKIESIGDNNNITLLTNKNKKQIVHKDRLKKFHS
What are the official names of this protein?
Retrovirus-related Pol polyprotein from transposon 412.
Protein: SSPP_STAAS
Sequence: MKRNFPKLIALSLILSLSVTPIANAESNSNIKAKDKKHVQVNVEDKSIPTEVRNLAQKDYLSYVTSLDKIYNKEKASYTLGEPFKIYKFNKKSDGNYYFPVLNTEGNIDYIVTISPKVTKYSSSSSKYTINVSPFLSKVLNQYKDQQITILTNSKGYYVVTQNHKAKLVLKTPRLEDKKLKKTESIPTGNNVTQLKQKASVTMPTSQFKSNNYTYNEQYVNKLENFKIRETQGNNGWCAGYTMSALLNATYNTNKYHAEAVMRFLHPNLQGQRFQFTGLTPREMIYFGQTQGRSPQLLNRMTTYNEVDNLTKNNKGIAVLGSRVESRNGMHAGHAMAVVGNAKLDNGQEVIIIWNPWDNGFMTQDAKNNVIPVSNGDHYQWYSSIYGY
What is the function of this protein?
Cysteine protease that plays an important role in the inhibition of host innate immune response.  Cleaves host elastins found in connective tissues, pulmonary surfactant protein A in the lungs, and the chemokine receptor CXCR2 on leukocytes.  Proteolytic cleavage of surfactant protein A impairs bacterial phagocytosis by neutrophils while CXCR2 degradation blocks neutrophil activation and chemotaxis.  Additionally, promotes vascular leakage by activating the plasma kallikerin/kinin system, resulting in hypotension.
What are the official names of this protein?
Staphopain A, Staphylococcal cysteine proteinase A, Staphylopain A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C47 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DER_LEUMM
Sequence: MSAPIVAIVGRPNVGKSTIFNRMAGERIAIVEDMPGVTRDRLYAPAEWLNYEFRMIDTGGIEIGDAPFLAEIRGQVELAINEADVIVMVVSGREGLTEADEVVARMLYKSDKPVVLAVNKVDNPEMRHDVYDFYALGLGDPFPVSGSHGLGLGDLLDEIVKHFPDEAAEQEDDAIRFSIIGRPNVGKSSIVNAMLGEKRVIVSDIEGTTRDAIDTRFVTEEGDEFVMVDTAGMRKRGKIYENTEKYSVMRAMKAIDDSNVILMVIDAEAGIREQDKHVAGFAHEAGRAMIIVVNKWDAIEKNDRTMSDFENLIREEFKFLDYAPIVFVSAKTGQRLDRLPQMVKDVDDNHRKRITSSTLNDVIMDAIAINPTPSDNGRRLRVYYATQVATQPPTFVIFVNDVELMHFSYERFLENKIRESFDFTGTPIKLIVRARK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: ATPG_NATTJ
Sequence: MAQSTREIKRRISSVNSTKQITRAMEMVAAAKLRRAQQRVEDNRPYEEKMRQAIFRILNQAKTISHPLMESKGQDLPAGHIIMAADRGLCGGYNVNVAKAAAEHIGENKESTKIIAVGKYVRDYFKKRDYNVISEYLDIEDYPSFDRPQMIAEAVEQMFSDGVIGEVYLTFAEFQNAMIQRPVTRKILPMSKEAFLPPEEESENADDTEQNNQDPAETAGLEDQIYKFEPSAGAVLGGLLSSYMKSTLFRALLESKASEQGARMTAMKNATDNAEDMIEELTLSYNKARQGAITQEILEVVSGAEAAK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ENPP2_BOVIN
Sequence: MARRRSCQLHQVISLFTFAVGVNICLGVTANRIKRAEGWGEGPPTVLSDSPSINISGSCKGRCFELQEAGPPDCRCDNLCKSYSSCCLDFDELCLKTAGGWECTKDRCGEVRNEDHACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKTPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDAHFNLRGREKFNHRWWGGQPLWITATKQGVIAGTFFWPVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLRDIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDIILVPGTLGRIRPKFNNHAKYDPKVIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDVHLLVERRWHVARKPLEVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTVPEEVTRPNYPGVMYLQSDFDLGCTCDDKAEPKNKLDELNKHLHIKESTEAETRKFRGSKNEIKENVNGNFEPRKERHLLYGRPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQADVSDIPAHLTNCVRPDVRVSPSFSQSCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRIWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTQDKIKQYVEGSSVPVPTHYYSILTSCLDFTQPADRCDGPLSVSAFVLPHRPDNDESCNSSEDESKWVEELLKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLQTYESEI
What is the function of this protein?
Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids.  Major substrate is lysophosphatidylcholine (PubMed:12119361).  Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility.  Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP.  Involved in several motility-related processes such as angiogenesis and neurite outgrowth.  Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation.  Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.  May have a role in induction of parturition.  Possible involvement in cell proliferation and adipose tissue development.  Tumor cell motility-stimulating factor (By similarity).  Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity).  Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity).
What are the official names of this protein?
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, E-NPP 2, Autotaxin, Extracellular lysophospholipase D, LysoPLD.
What is the protein family that this protein belongs to?
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
What are the subcellular locations of this protein?
Secreted.