PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_SHESA
Sequence: MIEADRLIQPQLQGQDDVIDRAMRPKLLDEYTGQDDTRAQLKVFIQAAKNREEALDHMLIYGPPGLGKTTLAMIVANEMGVNIKSTSGPVLEKAGDLAALLTNLEAGDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGALTSPLRARFGIPLRLEFYNVKDLSTIVTRSAQVMGLAIDSEGATEIAKRSRGTPRIANRLLRRVRDYAEVKHDGAVTQKVAEQALDLLDVDGEGFDYMDRKLLLAIIDKFMGGPVGLDNLAAAIGEERETIEDVLEPFLIQQGFIQRTPRGRIATTRAYLHFGMIKPE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RK16_CARPA
Sequence: MLSPKRTRFRKQHRGRLKGISYRGNRICFGRYALQALEPTWITSRQIEAGRRAMTRNIRRGGKIWVRIFPDKPVTLRPTETRMGSGKGSPEYWVAVVKPGRILYEMSGVAENIARRAISIAASKMPIKTQFIISG
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: REN_TPCTV
Sequence: MDSRTGELLTYTQCQTGCYFDDIKNPIYFRLQNTTTMATGNKIITLQIRANHNLRKVLGLQICWLNLVVLSVSPRLSGEALLDRFKFHVMKHLNNLGVISINNVIRSINHFIDLFDQRVFYAPSFYYNIKMRLY
What is the function of this protein?
Increases viral DNA accumulation.  Enhances infectivity and symptom expression (By similarity).
What are the official names of this protein?
Replication enhancer protein, REn, 16.1 kDa protein, Protein C3, Protein L3.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae replication enhancer protein family.
Protein: RL24_ESCF3
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RECO_BURTA
Sequence: MTDEADADPQPFAVPPAPGAPAANKPARKPRRTVPRTSEFRIAEQPGFVLHSYPYRETSLVIDVLTRDHGRIALVAKGAKRPHSALRGVLQTFQPLSLSWSGKSELRTLTGAEWVGGMLPLAGDALLCGFYANELLVKFCAREDPHPPLFQHYLVTLTRLAHGEPPVQVLRSFERVLLRETGYAMTLKRTVARRAVEPGKLYVFDPERGVRDADSDVPPHWPVIAGQTLLDMEEDDYHRAQTVAQSKTLMRFLLNTYLGGTPLATRQILIDLQNL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: ILVD_STRPJ
Sequence: MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVISTWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDIIADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKDIDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLPGSSSHPAESADKKEDIEAAGRAVVKMLELGLKPSDILTREAFEDAITVTMALGGSTNATLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLLANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDGAVAKVSGVKVRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGDKVALLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWNMDKSGKK
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CMT2_CRYNH
Sequence: MAFNPNPEKTTSCCSTSKAQDKCTCPKGKCECETCPKSTKTPGSGPCNCGVKEKVSTCGCNGSGAACTCPPGQCACDSCPRKAKSVSTCGCGGSAAACSCPPGKCACDSCPKQAQEKVSSCACNGSGGACTCPPGKCSCSGCPAQAKENPADQPTTCGCQGVGVACTCPPGQCACDGCPAKAK
What is the function of this protein?
Copper metallothionein that protects the cell against copper toxicity by tightly chelating copper ions (PubMed:21819456, PubMed:23498952).  Required for antioxidant-mediated growth rescue in the presence of fluconazole (PubMed:31694529).  Acts as a critical factors for lung colonization and virulence (PubMed:23498952).
What are the official names of this protein?
Copper metallothionein 2, Cu-MT 2, Cu-metallothionein 2, Copper chelatin 2, Copper thionein 2.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex.
Protein: RL5_STRS7
Sequence: MANRLKEKYTNEVIPALTEKFNYTSVMAVPKVEKIVLNMGVGDAVSNAKNLEKAAAELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLDKLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEINFDDVDKVRGLDIVIVTTANTDEESRELLKGLGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: GMT1_YEAS1
Sequence: MSELKTGHAGHNPWASVANSGPISILSYCGSSILMTVTNKFVVNLKDFNMNFVMLFVQSLVCTITLIILRILGYAKFRSLNKTDAKNWFPISFLLVLMIYTSSKALQYLAVPIYTIFKNLTIILIAYGEVLFFGGSVTSMELSSFLLMVLSSVVATWGDQQAVAAKAASLAEGAAGAVASFNPGYFWMFTNCITSALFVLIMRKRIKLTNFKDFDTMFYNNVLALPILLLFSFCVEDWSSVNLTNNFSNDSLTAMIISGVASVGISYCSGWCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPRNFLSILSIFIGFLSGIIYAVAKQKKQQAQPLRK
What is the function of this protein?
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.  Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins.  Involved in vanadate sensitivity (By similarity).
What are the official names of this protein?
GDP-mannose transporter 1, GMT 1, Low dye-binding protein 3, Morphogenesis checkpoint-dependent protein 3, Vanadate resistance glycosylation protein 4.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Recycles between the Golgi apparatus and the endoplasmic reticulum.
Protein: HGPB_HAEIF
Sequence: MTNFRLNVLAYSVMLGLTASVAYAEPTNQPTNQPTNQPTNQPTNQPTNQPTNQPTNQNSNASEQLEQINVSGSTENTDTKAPPKIAETVKTAKTLEREQADNIKDIVTYETGVTVVEAGRLAQSGFAIRGVDENRVAINIDGLRQAETLSTQGFKELFEGYGNFNNTRNGAEIETLKEVNITKGADSIKNGSGSLGGSVIYKTKDARDYLINKDYYVSYKKGYATENNQSFNTLTLAGRYKKFDVLVVTTSRNGHELENYGYKNYNDKIQGKKREKADPYKIEQDSTLLKLSFNPTENHRFTFGADLYEHRSRGQDLSYTLKYQKTDPNLAEVDSRHTNDKTKRRNISFSYENFSQTPFWDTLKITYSDQRIKTRARTDEYCDAGVRHCEGTDNPTGLKVTDGKITRRDGSELQFEKKNNTAHSNGETYDFKKFIDTDKKVIEDKLTLKNPNDTWYDCSIFNCENNAKIKVFEGNYSYGYDGKWKEVDLEIKTLNGKKFAKIKDPTNKIKSILPSSPGYLERLWQERDLDTNTQQLNLDLTKDFKTWHIEHNLQYGGSYNTAMKRMVNRAGNDASDVQWWATPTLGYNFYDQPYTCATAYSWNANLCPRVDPEFSYLLPIKTTGKSVYLFDNLVITDYLSFDLGYRYDNIHYQPKYKRGITPKLPDDIVKGLFIPLPKNSNSKPDEVKKNVQQNIDYIAKQNKKYKAHSYSFVSTIDPTSFLRLQLKYSKGFRTPTSDEMYFTFKHPDFTILPNADLKPEIAKTKEIAFTLHNDDWGFISTSLFKTNYKNFIDLIFKGEKDFPLVSGGSSLPFSLYQNINRDNASLKGIEINSKVFLGKMAKFMDGFNLSYKYTYQKGRMNGNIPMNAIQPRTMVYGLGYDHPNHKFGFDFYTTHVASKNPEDTYDIYAKDKKQTDTSIKWRSKSYTILDLIGYVQPIKNLTIRAGVYNLTNRKYITWDSARSIRSFGTSNVIEQSTGLGINRFYAPGRNYKMSVQFEF
What is the function of this protein?
Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake.
What are the official names of this protein?
Hemoglobin and hemoglobin-haptoglobin-binding protein B.
What is the protein family that this protein belongs to?
Belongs to the TonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: YCAR_SALSV
Sequence: MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLENEARSLTSDESKS
What are the official names of this protein?
UPF0434 protein YcaR.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: COX41_PIG
Sequence: MLATRVFNLIGRRAISTSVCVRAHGSXVKSEDYALPVYVDRRDYPLPDVAHVKNLSASQKAXKEKEKASWSSLSMDEKVELYRLKFNESFAEMNRST
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial, Cytochrome c oxidase polypeptide IV, Cytochrome c oxidase subunit IV isoform 1, COX IV-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase IV family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: OMT3_DICDI
Sequence: MNNKTSNGDITNDEPTVGSKRSWTDVNYKFCEDKEKQVVEEIQTETSWADVDWDSVRESIAKSITEKETDIIGEEDKIHHEDNAMDYWDKFYKKNQNKFFKDRTYLHLEFPELNPLKITRDETFIFFEDDDAAAEGAENGGGGGGSDNLYQDKDDLEKQEKEREKKMANLLSKNVDIKELKNRWVKDIQELTNDESKKLTVLEIGCGTGATVYPLLKLNPEKYFYVFDFSPHAVNLVKSNSLYNEAKLNAFVCDIATEQIPTSIVKDNSIDMMLMIFVLSAISRDKMHAVANSLFKSLKPGGVLYIRDYGLYDMTQLRFISKKGKKIDENFYLRADGTRTYFFTTQVLSEIFEAAGFKTLVSKYDTRELRNRKRMISMYRVWVRGKFMKPLDNENTENNSKILSIYNDPINNNNNNNNNNNNNNNNTTTTTSTTTTN
What is the function of this protein?
Probable methyltransferase.
What are the official names of this protein?
O-methyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METL family.
Protein: GSFC_PENAE
Sequence: MTLDQISRIQALVAEIADLSQTFEGPSERFMVDGLPFLRKSEELVTLVQSPAEHATSLIIKTMETAVIRTLLSLNVLQTIPTTGSITLQSLAVATETQESLLERLLRVVTKTGFIIRENGGYSHSHTSLAYAGPLGALFAPCYDEGIRALVRLPEYLSVKDKEEAKNARYSLFTWNEGQEGKATFEILSTMPARTEGIHTLAMNVQHLRPYTGFFDYSKLVSEDRERPVFVDVGGGNGHVIKEILQAFPQIRPEQCVLEDRAETLELARTTGLLPAGVQLLEHDYLTRQPVSNAKAYHLRAVAYNLGDAELVQLLKQIVPVMGADSKVLIAENILFDDNSTVFSTVSDMIMLGIGGKERTEQNFREVLYEAGLTIEGIHRAPGLEYGIMEASLATS
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections (PubMed:20534346, PubMed:23978092).  The first step of the pathway is the formation of the heptaketide backbone by gsfA which is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units (PubMed:20534346, PubMed:23978092).  The resulting benzophenone can undergo a spontaneous dehydration to form norlichexanthone (PubMed:23978092).  However, the true precursor for the griseofulvin biosynthesis is not norlichexanthone, but the heptaketide benzophenone that is O-methylated at 3-OH by gsfB to produce griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C (PubMed:23978092).  Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B (PubMed:23978092).  The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin (PubMed:23978092).  Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin (PubMed:23978092).
What are the official names of this protein?
O-methyltransferase gsfC, Griseofulvin synthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: ABEC4_MOUSE
Sequence: MEPLYEEILTQGGTIVKPYYWLSLSLGCTNCPYHIRTGEEARVPYTEFHQTFGFPWSTYPQTKHLTFYELRSSSKNLIQKGLASNCTGSHNHPEAMLFEKNGYLDAVIFHNSNIRHIILYSNNSPCNEAKHCCISKMYNFLMNYPEVTLSVFFSQLYHTEKQFPTSAWNRKALQSLASLWPQVTLSPICGGLWHAILEKFVSNISGSTVPQPFIAGRILADRYNTYEINSIIAAKPYFTDGLLSRQKENQNREAWAAFEKHPLGSAAPAQRQPTRGQDPRTPAVLMLVSNRDLPPIHVGSTPQKPRTVVRHLNMLQLSSFKVKDVKKPPSGRPVEEVEVMKESARSQKANKKNRSQWKKQTLVIKPRICRLLER
What is the function of this protein?
Putative C to U editing enzyme whose physiological substrate is not yet known.
What are the official names of this protein?
Putative C->U-editing enzyme APOBEC-4, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: UPP_BACC2
Sequence: MGKLYVFDHPLIQHKITYIRDKNTGTKDFRELVDEVASLMAFEITRDLPLKDIEIETPVSKATTKVIAGKKLGLIPILRAGLGMVDGILKLIPAAKVGHVGLYRDPKTLQPVEYYVKLPTDVEERDFIVLDPMLATGGSAAEAINSLKKRGAKQIKLMCIVAAPEGVKVVQEEHPDVDIYVAALDEKLNDHGYVVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: ATPG_WOLSU
Sequence: MGSNLKEIRKKITSVKNTQKTTKAMKLVSTSKLKKAEEMAKRSRVYAERITAVFQEIKAKIEQNGFSGLESPYFTAGEDREVKMVDIVFVTADKGLCGGFNSTTIKEVTRLMAEYKSQNVKVRLRAIGKKGISFFGFNEVELLDKVSDLSATPDYERAAEFVNKATTDFINGVTDKVILVHNGFKNMISQELKVQDLLPIKADAIEAKESLGMMEVEPSEQEREILDQLAKKYIEFNMYYALIDSLAAEHSARMQAMDAASNNAGELVKSLTIAYNKARQEAITTELVEINTGVESMK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TX117_LYCSI
Sequence: MMKVLVVFALLVTLISYSSSEGIDDLEADELLSLMANEQTRKECIPKHHECTSNKHGCCRGNFFKYKCQCTTVVTQDGEQTERCFCGTPPHHKAAELVVGFGKKIFG
What are the official names of this protein?
U1-lycotoxin-Ls1b, Toxin-like structure LSTX-A17.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 04 (U1-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYA_MOOTA
Sequence: MTGNELRERFLKFFASKGHTIVHSSSLVPANDPTLLFTNAGMVQFKDVYLGLDRRPFTRATTAQKCVRAGGKHNDLDTVGRTARHHTFFEMLGNFSFGDYFKREAITYAWEFLTRVLELPPERLWVTVYQEDDEAYQLWQEIAGIPAERIVRMGEKDNFWAMGDTGPCGPCSEIIYDRGPEHACSSTPCALGACDCDRWLEIWNLVFMQYERDSNGNLSPLPRPSIDTGMGLERVASVLQGVDSNFDTDLIAPLIKAVEKITGRTYDPGEAGFPFRVIADHARSCTFLIADGILPGNEGRSYVLRRILRRAARFGKALGIDEPFLYRLVDTVVAIMGGAYPEVAEQQEHIARVIEQEEIRFHETLNDGLKVLNGILERARQEGREVVSGLEAFTLYDTYGFPLDLTEEIAGEGGFKVDRDGFEKAMAAQRERARAAREDVKAYDFALAFAGALEDISGTAFTGYDQLEDKGTVLALFQEGARVTSLEANATGYVVLDRTPCYPEGGGQVGDRGELKWSGGQARVEDTRRLPDGKIVHQINVTAGTLVVGQEVEIAVDRERRQATARNHTVTHLLHRALKNILGEHVNQAGSLVTPERLRFDFTHFAPLTGEELRAVEAEVNQKILANLPVTTLETSYQEAKAMGATALFGEKYGERVRVVKIDAYSMELCGGTHLGSTSEAGSFRLVSESGIGAGVRRVEAVTGAAALEMALQDRQELATIAGLLKVPPDQAIQRVRHLLEQNKENERELAQLRNELASYTIDKLLDRVQEVAGVPVLPARVQITDPEALREMAERLRSRLGSGVVILGSQHNGRVNFVAMVSKDLVQRGIHAGNLLREVARIASGGGGGRADMAQAGGKDPGKLDQALAYSLKVVAAQVR
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_RHOPT
Sequence: MSTTKRCYYETLEVERNADDSTLKSAFRKLAMKWHPDRNPGDPQCEIKFKEINEAYEVLKDGDKRAAYDRYGHAAFEQGGFGGGAGFGAGFASSFSDIFEDLFGMAAQRGRGTGRERGADLRYNMEITLEDAFKGKTAQIEIPVSVTCEACSGTGAKAGTKPKTCSTCGGAGRVRQAQGFFTLERTCPSCQGRGQTIEDPCPSCTGSGRVTKERTLSVNIPQGVEDGTRIRLAGEGEAGLRGGPPGDLYIFLSLANHAIFQRDGADLHCRVPISMVTAALGGEFEVPTIDRGKTKVKVPSGTQTGRRFRIAGKGMPVLRSRQVGDMYVQVVVETPQNLTKKQQELLAEFEKLSSGETQPEAVGFFSKVKEFFGSRASAP
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTNB1_DANRE
Sequence: MALTNTTITSWKLQEIVAHSSNVSSLVLGKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYSGSENTLRVYGWEPDRCFDVVHVGWGKVSDLAISNNQMIAVSYSHTNVSWYVVDLNRVKKSGSVIQGLIQDKPIPAPSSALGTTLRRNYERPTTSCTGQEMKQSSEADRRSPEGERRSPSSEDEKEDKESSAEITNPEDYKEIFQPRSVISRTPPKTTEPFPAPLEHSFSESVLEKPGPVVKIVTPVIDRAGQLKGPITSSTPVQRVEPTVIAAAPRPVAVVTTSASSPSRPVVNTTKPKPSTGIILSTRNEPIGLNAGDFLSHARNAKASAMGDEEALAQIRKGHDTMCVMLSSRSKNLDSVRSVWASGDVKTSLDSAVSMNDLSIVVDVLNIINLKPSLWKLDLCTSILPQIEELLQSRYESYVQTGCMSLKLILKRFWPLISDTLNAPPSVGVDITREERHQKCKACYKQLKNLSNVVKNRAEQVGRHGSTFRELQLLMAPLDY
What is the function of this protein?
Participates in a complex which severs microtubules in an ATP-dependent manner.  May act to target the enzymatic subunit of this complex to sites of action such as the centrosome.  Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
What are the official names of this protein?
Katanin p80 WD40 repeat-containing subunit B1, Katanin p80 subunit B1, p80 katanin.
What is the protein family that this protein belongs to?
Belongs to the WD repeat KATNB1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.
Protein: XCR1_HUMAN
Sequence: MESSGNPESTTFFYYDLQSQPCENQAWVFATLATTVLYCLVFLLSLVGNSLVLWVLVKYESLESLTNIFILNLCLSDLVFACLLPVWISPYHWGWVLGDFLCKLLNMIFSISLYSSIFFLTIMTIHRYLSVVSPLSTLRVPTLRCRVLVTMAVWVASILSSILDTIFHKVLSSGCDYSELTWYLTSVYQHNLFFLLSLGIILFCYVEILRTLFRSRSKRRHRTVKLIFAIVVAYFLSWGPYNFTLFLQTLFRTQIIRSCEAKQQLEYALLICRNLAFSHCCFNPVLYVFVGVKFRTHLKHVLRQFWFCRLQAPSPASIPHSPGAFAYEGASFY
What is the function of this protein?
Receptor for chemokines SCYC1 and SCYC2.  Subsequently transduces a signal by increasing the intracellular calcium ions level.  Receptor for XCL1/Lymphotactin.
What are the official names of this protein?
Chemokine XC receptor 1, G-protein coupled receptor 5, Lymphotactin receptor, XC chemokine receptor 1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACDB2_METAC
Sequence: MAEFPFEISPMFEGERVRKEGMFVELGGPKSLGLELVRAKPMDEIEDDKVTIVGPDLKEMEEGKTYPWAMIFNIGGELVEPDLESVVERRVHDFINYCQGIMHLNQRYDVWMRVSKDTAAKMDSFEPFGQAVMMLFKTELPFIEKMQVTFYTEQAEVEKQLEEAKAIFKARDERTKDLHDEDVDVFYGCTLCQSFAPTNVCVVSPDRVSLCGAINWFDGRAAAKVDPEGPQFEITKGDLIDAEKGEYTGVNDIAKKLSAGEFDKIKLHSFFDAPHTSCGCFEVVGFYIPEVDGIGWVNREYQGMAPNGIGFSTMAGQTGGGKQIVGFLGIGINYFYSPKFIQADGGWNRVVWLPSMLKDKIAETIPEDLKDKIATENDATDIESLKAFLQEKGHPVVATWAAAEEEEEEEEEEEEEVAVAAAPMMMPAAGFQMPAMPMMSGGSSGGIKLTFKNAKITIDKMIISEKKEKK
What is the function of this protein?
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.  The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA.  The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).
What are the official names of this protein?
Acetyl-CoA decarbonylase/synthase complex subunit beta 2, ACDS complex subunit beta 2, ACDS complex acyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the CdhC family.