PharMolix/UniProtQA huggingface dataset:
Protein: TRMB_HISS2
Sequence: MTEQKITFADQKRKTVEIAEFTEDGRYKRKVRSFVLRTGRLSEFQRNMMNNNWATLGLEYQTTAFDFTQIYGNTNPVILEIGFGMGKSLVEMALQNPDKNYLGIEVHTPGVGACIAYAVEKQVKNLRVICHDATEILQDCIADNSLAGLQLFFPDPWHKTKHHKRRIVQPHFVEKIQQKLVPNGFVHMATDWENYAEYMLEVLTSAVGLHNTSATNDYIPRPDFRPLTKFEQRGHKLGHGVWDLFFIKNIT
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RSGA_OPITP
Sequence: MTLSSLGWDDFFAGAFQPFASENFLPARVALEHKHACVLLSARGEITATCTGRLLHETATRAALPAVGDWVAVRLRPESLASGAGVALVGDIHAVLPRRTAFTRRAVGDADAEQVLATNVDTVFLVTGLDRDFNLRRIERYLAVARASEAQPVVVLNKSDLHPDARGAEAEVRRITRTAPVVTLSAARGDGIAALAPWLVPGATVALLGSSGAGKSTLINRLLGKQRQDTGPLSHAMNKGRHTTTHRELLALPGGALVIDTPGLRELQLWGVDESAVAETFPEVAALAAECRFPDCTHQREPGCAVRAALDDGTLDPTRWASYEKLQREQAYAARRVDPVLARAERDRWKKIYQGQRARERIEGRWE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSQ_GEOSM
Sequence: MRDLHAKKQRVPHNRVKKPPKERKPINWGPILKFASRGFGGAALCAGLGFGGWQLYNLVSRTTLLRLEAIEVSPLKRVSREEIITLAGVRPGDSMLKVDLKTVVARLSKNPWLEEVQVRRYFPHTLSITVSERAPQAVANVGCLYYLDDKGVLFKSLVEGDRLDYPLITGFTEEELAQDPKGCQEALKNALALIDTLKNGGVFSLEDISEIHYSKGYGFTLFTMQGGVPVKLGNGGFGEKLTRLAGIYKELQPQMQALDYIDLDYADKIIVKKV
What is the function of this protein?
Essential cell division protein.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: COX3_DUGDU
Sequence: MTHQTHAYHMVNPSPWPLTGALSALLMTSGLVMWFHYHSTILVLLGLLTNILTMYQWWRDVVREGTFQGHHTPTVQKGLRYGMVLFIISEVFFFAGFFWAFYHSSLAPTPELGGCWPPTGIHPLDPMEVPLLNTSVLLASGVTITWAHHSLMEGNRKQMLQALFITISLGIYFTLLQASEYHEASFSISDGIYGSTFFMATGFHGLHVIIGSTFLAVCFLRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HSP7F_ARATH
Sequence: MASSAAQIHVLGGIGFASSSSSKRNLNGKGGTFMPRSAFFGTRTGPFSTPTSAFLRMGTRNGGGASRYAVGPVRVVNEKVVGIDLGTTNSAVAAMEGGKPTIVTNAEGQRTTPSVVAYTKSGDRLVGQIAKRQAVVNPENTFFSVKRFIGRKMNEVDEESKQVSYRVVRDENNNVKLECPAINKQFAAEEISAQVLRKLVDDASRFLNDKVTKAVITVPAYFNDSQRTATKDAGRIAGLEVLRIINEPTAASLAYGFDRKANETILVFDLGGGTFDVSVLEVGDGVFEVLSTSGDTHLGGDDFDKRVVDWLAAEFKKDEGIDLLKDKQALQRLTEAAEKAKIELSSLTQTNMSLPFITATADGPKHIETTLTRAKFEELCSDLLDRVRTPVENSLRDAKLSFKDIDEVILVGGSTRIPAVQELVRKVTGKEPNVTVNPDEVVALGAAVQAGVLAGDVSDIVLLDVTPLSIGLETLGGVMTKIIPRNTTLPTSKSEVFSTAADGQTSVEINVLQGEREFVRDNKSLGSFRLDGIPPAPRGVPQIEVKFDIDANGILSVSAVDKGTGKKQDITITGASTLPKDEVDQMVQEAERFAKDDKEKRDAIDTKNQADSVVYQTEKQLKELGEKIPGEVKEKVEAKLQELKDKIGSGSTQEIKDAMAALNQEVMQIGQSLYNQPGAGGPGAGPSPGGEGASSGDSSSSKGGDGDDVIDADFTDSQ
What is the function of this protein?
In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions.
What are the official names of this protein?
Heat shock 70 kDa protein 6, chloroplastic, Chloroplast heat shock protein 70-1, cpHsc70-1, Heat shock protein 70-6, AtHsp70-6.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 (TC 1.A.33) family. DnaK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: EFTU_BACC0
Sequence: MAKAKFERSKPHVNIGTIGHVDHGKTTLTAAITTVLAKAGGAEARGYDQIDAAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDGGILVVSAADGPMPQTREHILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLSEYGFPGDDIPVIKGSALKALQGEADWEAKIIELMAEVDAYIPTPERETDKPFLMPVEDVFSITGRGTVATGRVERGIVKVGDVVEIIGLAEENASTTVTGVEMFRKLLDQAQAGDNIGALLRGVAREDIQRGQVLAKSGSVKAHAKFKAEVFVLSKEEGGRHTPFFANYRPQFYFRTTDVTGIIQLPEGTEMVMPGDNIEMTIELIAPIAIEEGTKFSIREGGRTVGYGVVATIVE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VGP_EBORS
Sequence: MGSGYQLLQLPRERFRKTSFLVWVIILFQRAISMPLGIVTNSTLKATEIDQLVCRDKLSSTSQLKSVGLNLEGNGIATDVPSATKRWGFRSGVPPKVVSYEAGEWAENCYNLEIKKSDGSECLPLPPDGVRGFPRCRYVHKVQGTGPCPGDLAFHKNGAFFLYDRLASTVIYRGTTFTEGVVAFLILSEPKKHFWKATPAHEPVNTTDDSTSYYMTLTLSYEMSNFGGKESNTLFKVDNHTYVQLDRPHTPQFLVQLNETLRRNNRLSNSTGRLTWTLDPKIEPDVGEWAFWETKKNFSQQLHGENLHFQILSTHTNNSSDQSPAGTVQGKISYHPPTNNSELVPTDSPPVVSVLTAGRTEEMSTQGLTNGETITGFTANPMTTTIAPSPTMTSEVDNNVPSEQPNNTASIEDSPPSASNETIDHSEMNPIQGSNNSAQSPQTKTTPAPTASPMTQDPQETANSSKLGTSPGSAAEPSQPGFTINTVSKVADSLSPTRKQKRSVRQNTANKCNPDLHYWTAVDEGAAVGLAWIPYFGPAAEGIYIEGVMHNQNGLICGLRQLANETTQALQLFLRATTELRTYSLLNRKAIDFLLQRWGGTCRILGPSCCIEPHDWTKNITDEINQIKHDFIDNPLPDHGDDLNLWTGWRQWIPAGIGIIGVIIAIIALLCICKILC
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in GP2, releasing the fusion hydrophobic peptide.
What are the official names of this protein?
Envelope glycoprotein, GP1,2, GP.
What is the protein family that this protein belongs to?
Belongs to the filoviruses glycoprotein family.
What are the subcellular locations of this protein?
[GP2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In the cell, localizes to the plasma membrane lipid rafts, which probably represent the assembly and budding site. SUBCELLULAR LOCATION: [GP1]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=GP1 is not anchored to the viral envelope, but forms a disulfid-linked complex with the extravirion surface GP2. In the cell, both GP1 and GP2 localize to the plasma membrane lipid rafts, which probably represent the assembly and budding site. GP1 can also be shed after proteolytic processing. SUBCELLULAR LOCATION: [Shed GP]: Secreted. Note=GP2-delta bound to GP1 (GP1,2- delta) is produced by proteolytic cleavage of GP1,2 by host ADAM17 and shed by the virus.
Protein: HEM3_CLOBM
Sequence: MNFIIATRRSKLAQVQTEIIIDLLNKKHDIECEKLLIETVGDKILEVSLDKIGGKGLFVKDIEVAMLEQRADAAVHSMKDVPYEMPKGFEIIAIPEREDVRDAFISLDNIKFKDLREGAKIGTSSRRRAAQLKLLRPDLDIVPIRGNVQTRIEKIKKENLDGIILAVAGLKRVNLDHLITDYFDTKEMVPAIGQGALGIEVMEEHPKKELFKDLDHYNSKICVLAERAFMRELDGDCHSTIGAYASIKDNIMHIIGIFERKNKIVKKEITGTKDQYEKLGIALAEHILKD
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: MEP7_ARTGP
Sequence: MRFSVFLPAIAALSSAVAAQRSCGSIPHKAFSNELKEAMENSRTSSFSNVTSNVTINTYFHVITDGNTGKISDETLQKQIAVLNSDYKASGFSFKLVASDSVDNPTWAAGEDDMGMKSALRKGGYDTLNVYFVPMLREGLLGFCYFPMKNPSEGQKIKDGCVINSNSVPGGSAQNYNEGKTTTHEVGHFMGLYHVFNEQEGNCQQDGDMIEDTPVQGSASSGCPTGKDSCPQQGVDSIHNYMDYSYDSCLTEFSPGQIKRMQMLWQFRAGSGSGSVTRPRPKPPVLMDYEHRL
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Plays a pivotal role as a pathogenicity determinant during infections and contributes to the ability of the pathogen to persist within the mammalian host (By similarity).
What are the official names of this protein?
Extracellular metalloprotease MGYG_00389.
What is the protein family that this protein belongs to?
Belongs to the peptidase M43B family.
What are the subcellular locations of this protein?
Secreted.
Protein: HUTG_GEOKA
Sequence: MYQPPDAGHWTGRIDSVKDERAFRLHQRIRLLDLSQPLETAAERAAAFIGFACDEGVRRNQGRQGAKEAPAAVKAALARLPWHLPEGVVVYDAGDVVCIDERLEQSQTELGKAVARLLKNGMASIVIGGGHETAYGHYLGVREALGTDARLGILNIDAHFDLRPYDDGPTSGTMFRQILDQDDQVSYFCLGIQRLGNTAALFADAETYRCRYMLEDELTAGPIEAAYEQIEKFAADHDAVMLTFCMDAISAAAAPGVSAPSPFGLAPSLARALIRRIVSHPKTISVDLCEVNPLLDEGGKTVALAAAFCMEALLHFQRLQPRR
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: NDK_NITHX
Sequence: MAIERTFSILKPDATARNLTGAINALIEKAGLRIVAQKRIRMTREQAETFYAVHKARPFFGELVDFMISGPVVVQVLEGENAVLKHREIMGATDPSKAADGTIRKLHATSVGENSVHGSDATETAAVEIAQFFSGNEIVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSK_ARATH
Sequence: MMKGISSVSQSINYNPYIEFNRPQLQISTVNPNPAQSRFSRPRSLRVLSLSADPSANRNPKSAVDAHAPPLVVVGSANADIYVEIERLPKEGETISAKTGQTLAGGKGANQAACGAKLMYPTYFVGRLGEDAHGKLIAEALGDDGCGVHLDYVRSVNNEPTGHAVVMLQSDGQNSIIIVGGANMKAWPEIMSDDDLEIVRNAGIVLLQREIPDSINIQVAKAVKKAGVPVILDVGGMDTPIPNELLDSIDILSPNETELSRLTGMPTETFEQISQAVAKCHKLGVKQVLVKLGSKGSALFIQGEKPIQQSIIPAAQVVDTTGAGDTFTAAFAVAMVEGKSHEECLRFAAAAASLCVQVKGAIPSMPDRKSVLKLLKFSI
What is the function of this protein?
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium.  The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway (By similarity) (PubMed:27601466).  Can also use xylose and fructose as carbohydrate substrates with a low efficiency (PubMed:27601466).  Can use GTP, and, to a lower extent, CTP and UTP as alternative phosphoryl donors (PubMed:27601466).
What are the official names of this protein?
Ribokinase, AtRBSK, RK.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma, chloroplast nucleoid.
Protein: RSMA_HAMD5
Sequence: MNRKLYQGHFAKKRFGQNFLTDEFVIDQIISSIHPSPEQTLIEIGPGLGALTLPLADQMDKILVIELDRHLADRLNQHPQLKDKLILYQQDVMTVNFSELSATFKQPLRILGNLPYNISTPLLFHLFKDIHRIDDMHFMLQREVVNRLLAAPNTKAYGRLSVMVQYHCKVIPILEVPPDAFTPIPKVYSAMIRLLPYRSLSHPYPVTDIERLNLVTRQAFNQRRKTLHNSLGALFTDQELAETGICPKLRAENVSVEQYCLLANRLH
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD70_PIG
Sequence: MEEEGSGCNVPRLPWASILRAALLLLLIGMVIYCFLCGQRFTQQQLDSTGWDLAELLLNHTESRQDPRLRWQGSPALGRSFVHGPELDNGQLRIQRTGIYRLHIQVTLTNCSSSTWTVMPRQATLTLGICSPTTHSISLLRLNFHHTCRVASQRLTPLAKGDVLCTNLTLPLLPSRNADETFFGVQLVRP
What is the function of this protein?
Cytokine which is the ligand for CD27.  The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses.  Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
What are the official names of this protein?
CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Membrane; Single- pass type II membrane protein.
Protein: PIRC1_DANRE
Sequence: MSTNEIKNDYSAKEETAGPGDSNTSEIKTSDVYKVDKNLPSRFNNPDCFRYSHKTTNPLYRTTNQAYGSKKPTVHEMPTSFNGSRHRFSEHLLKSGMYRDNGFNTMLDKSRLSRPNETSVFYDRINFHSLYHTAGKS
What is the function of this protein?
Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.  Functions at the initial step of left-right asymmetry specification of the visceral organs.
What are the official names of this protein?
Piercer of microtubule wall 2 protein, Pierce1, UPF0691 protein C9orf116 homolog.
What is the protein family that this protein belongs to?
Belongs to the PIERCE1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: FLTOP_XENLA
Sequence: MATHYSANQYQSAFTPKQLHCWSIPKDFKQHPSTHDDYTQFIANERGHLLAGVPRSQKNPWGTFLGTWDLPTKIPPSKLSLTSRSAEASKRLTNWIQNSEELLHACNGLQPQISGKASGKTDPPRDSSQGQQDPPVEESNKQTPLYRGRSKAESNRSSHRSVSSEKGGITAGDKVLQAQS
What is the function of this protein?
Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells.
What are the official names of this protein?
Protein Flattop, Cilia- and flagella-associated protein 126.
What is the protein family that this protein belongs to?
Belongs to the Flattop family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Apical cell membrane. Cytoplasm, cytoskeleton, cilium axoneme. Note=Localizes to the apical cell membrane, the basal body and the primary cilium in monociliated node cells (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By similarity).
Protein: KGSDH_ACIAD
Sequence: MSENNGKQFINGQRVAANAPTIESINATDYQPTGYLFSQATLDEVDQAAQAAYQAFLKYQHTTQQQRADFLDEIAIQIENLGSKLQEVAAQETGLPLVRLQGETGRVTGQLRLFAELLRRGDFYGARIDTALPERKPLPRVDLRQYKIGVGPVAVFGASNFPLAFSTAGGDTVAALAAGCSVVFKAHSGHMATAELVAQAIEKAILNSGIPSGTFNMIFGSRVGANLVEHPLIQAAGFTGSLEGGMALFNLAQNRPQPIPFFAEMSSVNPVIVMPEALNARGEKVAQDTVASFNMGCGQFCTKPGLIIGIKSPAFDQFVTALIDTTRTAVPQIMLNQGTLKSYQQGIDALLNEQGFKCIASGQAPELISQAQPHLFQADQSVLLSGNPKLQHEVFGPMSIVIAVDDEATLLNGLEKLAGQLTATIIADESDLPQAKELLNLLTRKAGRVLFNGFPTGVEVSDAMVHGGPFPATSDSRGTSVGTGAIERFLRPVCYQNTSQVLLPDVLKDGNPLHITRLVNGVLTQN
What is the function of this protein?
Catalyzes the NAD(P)(+)-dependent oxidation of alpha-ketoglutaric semialdehyde (alphaKGSA) to alpha-ketoglutarate in the D-glutarate degradation pathway.
What are the official names of this protein?
Alpha-ketoglutaric semialdehyde dehydrogenase, alphaKGSA dehydrogenase, 2,5-dioxovalerate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: CXCL9_HUMAN
Sequence: MKKSGVLFLLGIILLVLIGVQGTPVVRKGRCSCISTNQGTIHLQSLKDLKQFAPSPSCEKIEIIATLKNGVQTCLNPDSADVKELIKKWEKQVSQKKKQKNGKKHQKKKVLKVRKSQRSRQKKTT
What is the function of this protein?
Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response.  Chemotactic for activated T-cells.  Binds to CXCR3.
What are the official names of this protein?
C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, HuMIG, MIG, Small-inducible cytokine B9.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: HTPX1_SACS2
Sequence: MDVRQRLISSMVISLGLTIISEGIVLIGIASLLHISLFFIFPALVIFWLFQWIISPYVVGRGGYEVSPNDPQYGWLYNLVRRIAEESKIKPPRVFVIDAPYPNAFAYGNRLGGMRVGITLPLLNILDVDELTAVIAHEVGHIKHRDVEIGMTIGLIPTVLGYISTLLMNFGYLALFLAADEIELLFAIAALAIGFVIFVVTFILQIFVLWFNRLRESYADYNSFLVLGEGSKALATALAKIEIYMQNIRIDPFTGIIVTAPPVKVEEKDPHLLVEQWLRTKVSAFKDILSTHPYPARRAQMIYRLIYGSNI
What are the official names of this protein?
Protease HtpX homolog 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL17_METS4
Sequence: MRHGYRGRRFNRTTEHRKAMFANMSAALIKHEQIVTTLPKAKDLRPVVEKLITLGKRGDLHARRQAIAQIRDEAMVKKLFEVLGPRYQARPGGYCRIMKAGFRYGDNAPLAVIEFVDRDVDARGRDSGPTQAAAEAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RIHB_ECOSE
Sequence: MEKRKIILDCDSGHDDAIAIMMAAKHPAIDLLGITIVAGNQTLDKTLINGLNVCQKLEINVPVYAGMPQPIMRQQIVADNIHGETGLDGPVFEPLTRQAESTHAVKYIIDTLMASDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGNFTPSAEFNIFADPEAARVVFTSGVPLVMMGLDLTNQTVCTPDVIARMERAGGPAGELFSDIMNFTLKTQFENYGLAGGPVHDATCIGYLINPDGIKTQEMYVEVDVNSGPCYGRTVCDELGVLGKPANTKVGITIDTDWFWGLVEECVRGYIKTH
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.  Has a clear preference for cytidine over uridine.  Strictly specific for ribonucleosides.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihB, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihB subfamily.
Protein: A312_LOXLA
Sequence: ADNRRPIWNLAHMVNAVAQIPSFLDLGANALEADVTFKGSVPTYTYHGTPCDFGRDCIRWEYFNVFLKTLKEYTTPGNAKYRDGFILFVLDLKTGSLSNDQVRPAGENVAKELLQNYWNNGNNGGRAYVVLSLPDIGHYEFVRGFKEVLKKEGHEDLLEKVGYDFSGPYLPSLPTLDATHEAYKKAGVDGHIWLSDGLTNFSPLGDMARLKEAIKSRDSANGFINKIYYWSVDKVSTTKAALDVGVDGIMTNHPNVLIGVLKENGYNDKYRLATYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) with high activity (56. 8 U/mg) (PubMed:16759681).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).  Is lethal to mice (PubMed:16759681).
What are the official names of this protein?
Dermonecrotic toxin LlSicTox-alphaIII1ii, Ll1, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D 1, SMD 1, SMase D 1, Sphingomyelinase D 1.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HDAC9_MOUSE
Sequence: MHSMISSVDVKSEVPMGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDSKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNLVTSFKKRVFEVAESSVSSSSPGSGPSSPNNGPAGNVTENEASALPPTPHPEQLVPQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSPLNASNSLKDKQKCETQMLRQGVPLPSQYGSSIAASSSHVHVAMEGKPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQSMEDRAASKDNSARSDSSACVEDTLGQVGAVKVKEEPVDSDEDAQIQEMECGEQAAFMQQVIGKDLAPGFVIKVII
What is the function of this protein?
Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3.  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development.  Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
What are the official names of this protein?
Histone deacetylase 9, HD9, Histone deacetylase 7B, HD7b, Histone deacetylase-related protein, MEF2-interacting transcription repressor MITR.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus.