PharMolix/UniProtQA huggingface dataset:
Protein: UPP_PSEFS
Sequence: MPTREIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLETYDIEGWAGTVQVEKIAGKKITVVPILRAGIGMLEGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPEINERLAMIIDPMLATGSSMVATIDLLKKAGCKDIRAMVLVAAPEGIAAVEKAHPDVQIYTASIDERLNEHGYIIPGLGDAGDKIFGTKQKDA
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: LBD20_ARATH
Sequence: MADQQRGHNTSDSRRKSLAGKRTSQQTPTSSLSSGGVSMAAATTGTGTASPCGACKFLRRKCVSGCIFAPHFGSDQGAARFAAVHKVFGASNVSKLLHHIPVNRRHDAVVTISYEAQARLSDPVYGCVSTILALQQQVASLQAELSVVQSQLINSRVAMANVMQQQTHHQQQQQQLVVMQQPEYSNNSSASTTLAGAAMNSFTMTADAAAVSYDVMAPTNLEHSLQPMPPHQQRRGDYQHEDEEESGADFSVAVGSTAVASKVIFPAEDFHRR
What are the official names of this protein?
LOB domain-containing protein 20, ASYMMETRIC LEAVES 2-like protein 21, AS2-like protein 21.
What is the protein family that this protein belongs to?
Belongs to the LOB domain-containing protein family.
Protein: CRTNC_METID
Sequence: MKIAIAGGGIGGLISALMLRKKGYEVSLFEKRDRLGGRLAFTEEQGYRIDEGPTIVLLPEMLTSILNEAGISRDQYELININPLYKLHFKDGSSYTKYNSIERQIQEIKENFPGNEEGFVQFMKDMEIRFNLGKDQFLEKSFHDKRTFWTRNNLKTLVHLKAYKSVNNSLKAYFQDERIRQAYSLQTLYIGGNPLDSPALYSLISFSEHKHGIYYLKGGYASLVTVLENALLNSGVKVMKNATVERVVTEGEQAAALIVNGEEVKADAFVLNGDFPGASKMIPKESMPARNYTASSSCVLLYFGLDKVYRDSPVHQFFMGSNFQQHMKEIFETKEVPSDPSIYAFHPSVIDSSLAPEGHGVLYALVPVPSGSPINWGEQEGFVEKVIDQLEERGFPGLRKSIQWKKVRTPDDKEMEGLFQGGSFGIAPTLFQSGVFRPQVKPSKLTNVYAAGASIHPGGGIPIVMQGAKLMVSAILSDHQNKEREGVSLSG
What is the function of this protein?
Involved in the biosynthesis of the major C30 carotenoid methyl 4'-[6-O-(acylglycosyl)oxy]-4,4'-diapolycopen-4-oic acid via 4,4'-diapolycopen-4-oic acid intermediate.  Catalyzes the oxidation of 4,4'-diapolycopen-4-al to yield 4,4'-diapolycopen-4-oic acid.
What are the official names of this protein?
4,4'-diapolycopen-4-al dehydrogenase, 4,4'-diapolycopen-4-al oxidase, 4,4'-diapolycopen-4-oate synthase, 4,4'-diapolycopene aldehyde oxidase.
What is the protein family that this protein belongs to?
Belongs to the carotenoid/retinoid oxidoreductase family. CrtN subfamily.
Protein: ISPF_MYCGA
Sequence: MNIRIGQGFDSHKLKTKKNSRVFLGGIPVRTDQQLIANSDGDVVLHALSDAVLGCGSFGDIGMYFDENDLSNKGLDSKTILNYCLKLIKKLKLEFVNIDLTIFAQDIRIDPIRFEIKSSLMKLTGCNSVNVKAKSYEEPKNEIACSCVVLMNTNK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: DCUP_CHLAA
Sequence: MRDRFLRACRRQPVDRTPIWLMRQAGRYMPEYRAIRERYGFLQMVKTPEVAAEVTLQPVQAFGVDAAIIFADILPPLEGLGLQLTYEKGEGPVIHNPIRSPHDVSVLRSCDPRETVAYTLAALQLVKRELNGLPLIGFSGAPFTLASYAIEGGGSREYRLTKRFMYEQPAAWHDLMERLSRLVADYLIAQIEAGADAVQIFDSWAGALSPADYRAYVLRHTQALVQTIRARLGDVTPPIIYFGTDMAGLAGEVRQIGADVLGVDWRIDLDVAWAQYGFNHAVQGNLDPMTLFAPPSIIAARARDILERAGGRPGHIFNLGHGILTETPVDHVRYLVEFVQSYPLPATAPVLQEVV
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP7_ROT46
Sequence: MYGIEYTTVLTFLISLVFVNYILKSVTRAMDFIIYRFLLVIILLAPFIKTQNYGINLPITGSMDTPYMNSTTSETFLTSTLCLYYPNEAATEIADTKWTETLSQLFLTKGWPTGSVYFKGYADIASFSVEPQLYCDYNIVLMKYDGNLQLDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISMGTSCTIKVCPLNTQTLGIGCSTTDINSFEIVANAEKLAITDVVDGVNHKLDVTTNTCTIRNCKKLGPRENVAVIQVGGPNILDITADPTTAPQTERMMRINWKRWWQVFYTIVDYVNQIVQVMSKRSRSLNSAAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: NCAP_I72A4
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYKRVDGKWMRELVLYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRKTRGAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGPAVASGYNFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACNSAAFEDLRLLSFIRGTKVSPRGKLSTRGVQIASNENMDTMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPAFSVQRNLPFDKSTIMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEVSFRGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: SYY_ANAD2
Sequence: MQNLLEALVSRSLVHDQTPGLQARLAQGPITGYVGFDPTADSLHVGHLLAVMSLAWLQRCGGTPIIVVGGGTGMVGDPSGKRSERPVLSVEEIDRNVAAIRAQLERFVSFEGQNAARVRNNADWLRAIGLMEFLRDVGKHFTVNYMLAKDSVKGRMESGISFTEFSYQLIQAYDFWHLFRSEKCELQMGGSDQWGNITAGAELVSRKDGASVHGLTFPLLTTASGTKFGKTEGGAVWLDPARTSPYKFFQFWLNTDDRDVERLLKFFTFLSVEEIAALLAEQARDPGKRPAQRRLAEDVTARVHGPDVTRSVVEASRILFGGTDLRAASADVLEVLAGEIPSATVTGDELAALTVADLLVKVGLAASKGEVRRGVAGRGFSLNGAVLESGDAKVAAGDLLAGGYALLQKGKRNYALVKVR
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEP_I77AA
Sequence: MDPNTVSSFQDILMRMSKMQLGSSSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNGKWREQLGQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLFEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: CTSRD_MACFA
Sequence: MLMLMLVAAVTMWLRPLVTAQPLCRARTVRTGKVFNVIQDVQGDRLYFRSTTTRLIKHPCKKNIALYLGKQVFFTTDNFETSLLPFTIPTSMQVGVPEVTSAHFTGSLLLLVVNHKVYTYDYESNSWNLSLGIKHPVTHVSGDNCCYTGSLFCVDVSNLVFAYFRGDQISQTYIYYSNTGGFSFWKYHYDRQAEIVGSLGGIFHLFSLSQVGMLVVDQGKGMFKYSDHPLNRSLGLSFDYNGTLDIVIAPGQKGILLLWFEKSLLFSRNAGQLVDTVRVKKGEQTLFTSIFEAQITIHNIAVNENELAVITREDNLYYGNLGIVPSSIIKFAHQHIWSEDAALMFRSSGILEILTPVRDTAFAAFDFQKCLLNIQAILMDPDLHVGRCNIEFLKGEFTYRMYTIDMHSQLELTALLIPQPGTSLIPLVMVSNPHSLGFQATFYESGYTSDGNTKYKLDIYLKQQQHWGRTDFNFTSSLKRATMSTLTVDIANKEISCVDIKPLSTLISVGCDLDKKIVIQNTVSACSKGVLDALALQDNYSFIIEKEFYDPGFQGRQSSKDLHVFYSYQQLGCPLLVYYDTPWKPVVELWKKDRFQEVVDAEYVLLEVNGQFSYSYSLTAKSAMCTSQPQNWTTMIKESGGPFFWNRENYVSCHDPNNDAPLRWPDVQYQILGGRTANQIVFSHNNGFYVFYISIVDPYYSYCQLETVFSIYVYGAFPVQLVSAGVVMVLLISSILGSVWLAYMIPRLLRTARGRRMTSFVAQLYGRCKTVCQFRASATARTGSKPMGRHRSS
What is the function of this protein?
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.  Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.  Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.
What are the official names of this protein?
Cation channel sperm-associated auxiliary subunit delta, CatSper-delta, CatSperdelta, Transmembrane protein 146.
What is the protein family that this protein belongs to?
Belongs to the CATSPERD family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein. Note=Specifically located in the principal piece of sperm tail.
Protein: Y3148_ARATH
Sequence: MSLNRQLLFTYYFIVSLILFSDFVSSATLPKEEVDALQSVATALKKSNWNFSVDPCDETLSEGGWRNPNAAKGFEDAVTCNCSSVICHVTNIVLKAQDLQGSLPTDLSGLPFLQELDLTRNYLNGSIPPEWGASSLLNISLLGNRISGSIPKELGNLTTLSGLVLEYNQLSGKIPPELGNLPNLKRLLLSSNNLSGEIPSTFAKLTTLTDLRISDNQFTGAIPDFIQNWKGLEKLVIQASGLVGPIPSAIGLLGTLTDLRITDLSGPESPFPPLRNMTSMKYLILRNCNLTGDLPAYLGQNRKLKNLDLSFNKLSGPIPATYSGLSDVDFIYFTSNMLNGQVPSWMVDQGDTIDITYNNFSKDKTEECQQKSVNTFSSTSPLVANNSSNVSCLSKYTCPKTFYGLHINCGGNEITSNETKYDADTWDTPGYYDSKNGWVSSNTGNFLDDDRTNNGKSKWSNSSELKITNSSIDFRLYTQARLSAISLTYQALCLGKGNYTVNLHFAEIMFNEKNMYSNLGRRYFDIYVQGKREVKDFNIVDEAKGVGKAVVKKFPVMVTNGKLEIRLQWAGKGTQAIPVRGVYGPLISAVSVDPDFIPPKEPGTGTGGGSSVGTVVGSVIASTVFLVLLIGGILWWRGCLRPKSQMEKDFKNLDFQISSFSLRQIKVATDNFDPANKIGEGGFGPVHKGIMTDGTVIAVKQLSAKSKQGNREFLNEIAMISALQHPHLVKLYGCCVEGDQLLLVYEYLENNSLARALFGPQETQIPLNWPMRQKICVGIARGLAYLHEESRLKIVHRDIKATNVLLDKELNPKISDFGLAKLDEEENTHISTRVAGTYGYMAPEYAMRGHLTDKADVYSFGVVALEIVHGKSNTSSRSKADTFYLLDWVHVLREQNTLLEVVDPRLGTDYNKQEALMMIQIGMLCTSPAPGDRPSMSTVVSMLEGHSTVNVEKLLEASVNNEKDEESVRAMKRHYATIGEEEITNTTTTDGPFTSSSTSTANANDLYPVKLDSAYWNTRT
What are the official names of this protein?
Probable leucine-rich repeat receptor-like serine/threonine-protein kinase At3g14840.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: MET16_MOUSE
Sequence: MALSKSMHARNRYKDKPPDFAYLASKYPDFKQHIQINLNGRVSLNFKDPEAVRALTCTLLREDFGLSIDIPLERLIPTVPLRLNYIHWVEDLIGHQDSDKTTLRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQNNLSDLIKVVKVPQKTLLMDALKEESEIVYDFCMCNPPFFANQLEAKGVNSRNSRRPPPSSVNTGGITEIMAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKEELRIQGVPKVTFTEFCQGRTMRWALAWSFYDDVTVPSPPSKRRKLEKPRKPITFVVLESVMKELSLKASSLGSETAEGIVVVTTWIEKILTDLKVQHKRIPCGREEVSLFLTAIENSWIHLRRKRRERVRQLREVPRAPEDVILALEERKSTPKELSSGQDVAHSPQESALCGLDVPGGEAAADGGHCLSQKLLCQEETPEATEDERDEERGGMEAMESCKGSSNGAQDGEASEKGDRLDGAAGRYLFKCLVNIKKEAGDAVVEMHWVEGQNRDLMNQLCTYVRNQILRLVAS
What is the function of this protein?
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:29262316, PubMed:30197299).  Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (By similarity).  In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (By similarity).  Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (By similarity).  In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:29262316).  In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (By similarity).  Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (By similarity).  Specifically binds the 3'-end of the MALAT1 long non-coding RNA (By similarity) (PubMed:29262316, PubMed:30197299).
What are the official names of this protein?
RNA N6-adenosine-methyltransferase METTL16, Methyltransferase 10 domain-containing protein, Methyltransferase-like protein 16, N6-adenosine-methyltransferase METTL16, U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: PF36P_PLABA
Sequence: MKRRRIFMYYCFCFLLKYVAFSNVTNPNTTLGHFEICKINIYSGDAEECVLENEFGKMFLFICDIDYNEMSKNIVLPSECAKKTYIDHVNPNGTSPEVNTYDIFPDLIGANESKFRDKFYFYGTPYSSKDIDFICLCFSEVKPDIKHIIKMSFKKMTKKIKGCDFGDNVPTKKDLTNGKALYENSSCHIYAYPGDVIGINCYKKDINNIYNNNLELSPNNCFHNVYYENDILLSSKNLIPNSRVIPDPSNDVKLSKMHSYMSYIILPDEINENVKISCSCKRNEYVGTMFLYVNTSKNILTYTGNNSIISNHANKKYYEHMKIYKGNKMDPSDEDESNENAHNGNRANKDANYSEKMVDNRRQKNNSLNHTNYHGNYNENDNEINISTHDKYYEDHHLGSNRPLRKKRTFWQNLFGTSSSYYEVFNYFSIAFILIIHMLLW
What is the function of this protein?
Involved in sporozoite infection of hepatocytes and replication therein.
What are the official names of this protein?
Sporozoite surface protein P36p, Sporozoite surface protein P52, Sporozoite surface protein Pbs36p.
What are the subcellular locations of this protein?
Cell surface. Cell membrane; Lipid-anchor, GPI-anchor. Note=Present on the surface of sporozoites.
Protein: TADBP_MOUSE
Sequence: MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKDYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSPDEPLRSRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDKVAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGGNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
What is the function of this protein?
RNA-binding protein that is involved in various steps of RNA biogenesis and processing.  Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs.  In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases.  Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts.  Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening.  In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (By similarity).  Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263).  Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980).  Negatively regulates the expression of CDK6 (By similarity).  Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563).
What are the official names of this protein?
TAR DNA-binding protein 43, TDP-43.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, Stress granule. Mitochondrion. Note=Continuously travels in and out of the nucleus. Localizes to stress granules in response to oxidative stress. A small subset localizes in mitochondria.
Protein: DF286_ARATH
Sequence: MNNFRITIVAFLAVLVFTTTVTNSLDEPNMDTISKSREYKCKIDLDCSNHIACRHCSYRNCKCDHGTCKCMP
What are the official names of this protein?
Defensin-like protein 286.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: GAT25_ARATH
Sequence: MFGRHSIIPNNQIGTASASAGEDHVSASATSGHIPYDDMEEIPHPDSIYGAASDLIPDGSQLVAHRSDGSELLVSRPPEGANQLTISFRGQVYVFDAVGADKVDAVLSLLGGSTELAPGPQVMELAQQQNHMPVVEYQSRCSLPQRAQSLDRFRKKRNARCFEKKVRYGVRQEVALRMARNKGQFTSSKMTDGAYNSGTDQDSAQDDAHPEISCTHCGISSKCTPMMRRGPSGPRTLCNACGLFWANRGTLRDLSKKTEENQLALMKPDDGGSVADAANNLNTEAASVEEHTSMVSLANGDNSNLLGDH
What is the function of this protein?
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
What are the official names of this protein?
GATA transcription factor 25, Protein TIFY 1, Protein ZIM.
What is the protein family that this protein belongs to?
Belongs to the type IV zinc-finger family. Class C subfamily.
Protein: ZDH17_RAT
Sequence: MADGPDEYDTETGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHVDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGGNVDAQNVKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLSFLSIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCVSYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQITCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes.  Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity).  Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (By similarity).  Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (By similarity).  Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity).  May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (By similarity).  May play a role in Mg(2+) transport (By similarity).  Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity).  Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation (By similarity).
What are the official names of this protein?
Palmitoyltransferase ZDHHC17, Acyltransferase ZDHHC17, Zinc finger DHHC domain-containing protein 17.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Presynaptic cell membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.
Protein: OCCM_RHIRD
Sequence: MPFDPAFLWQTFVALLSGIPLALQLAVFSVALGTVLAFGLALMRVSRLWWLDLPARFYIFAFRGTPLLVQIYIIYYGLSQFPDVRHSFIWPFLRDAYWCAMAALALNTAAYTAEIMRGGLLSVPAGQIEAAKACGMGRVKLFRRIVIPQAIRQMLPGYSNEVILMVKSTSLASTITIMEITGIAAKLISESYRTVEVFSCAGAIYLILNFIVARLFTLLEWALWPERRNNRLTTDPVDRKGELHA
What is the function of this protein?
Component of the octopine active transport system probably consisting of four subunits: Q, M, P and T.
What are the official names of this protein?
Octopine transport system permease protein OccM.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSBF_GOSHI
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.