PharMolix/UniProtQA huggingface dataset:
Protein: CCU41_ARATH
Sequence: MAELENPSVMSKLIAFLSSLLERVAESNDLTRRVATQSQRVSVFHGLSRPTITIQSYLERIFKYANCSPSCFVVAYVYLDRFTHRQPSLPINSFNVHRLLITSVMVAAKFLDDLYYNNAYYAKVGGISTKEMNFLELDFLFGLGFELNVTPNTFNAYFSYLQKEMTLLQPLSLVVVPSSRSLITFNDDEASHQKQQQQQLAV
What are the official names of this protein?
Cyclin-U4-1, CycU4;1, Cyclin-P4.1, CycP4;1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin U/P subfamily.
Protein: SYP_SYNSC
Sequence: MRVSRLLLVTLRDVPAEAEITSHQLLLRAGYIRRVGSGIYAYLPLMWRVLQKITAVVREEMNRAGAQETLLPQLHPAELWQKSGRWQGYTAGEGIMFHLEDRQGRELGLGPTHEEVITSLAGELLRSYRQLPVNLYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFHASEADLRETYGAMDQAYRRIFERCGLDAVPVDADSGAIGGAASQEFMVTADAGEDLILISDDGQYAANLEKAVSIPSAASPLPDGPEESIPTPGLGSIESLCDTKCWDPSQVVKVLLFVATLDDETLQPLLVSLRGDQELNPTKVVNAVSRTLNKGVLDCRPITPDYTNRQQIDPIPFGSIGPDLSDDVLKGAKTWQPTFLRLADETASELGSFICGANQPDLHRFNTSWTAIEQKPTTLDLRNARAGDVCQHNLESRLTEKRGIEVGHIFQLGRKYSEAMESGFTNENGKTEPFWMGCYGIGVSRLAQAAVEQHHDDSGICWPTAIAPFEAIVVVANIQDDTQGQLGEALYAELQAADVDVLLDDRKERAGVKFKDADLIGIPWRIVVGRDASEGIVELVRRSSREVRKLPHAEAVSCLIKALHP
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NBR1_RAT
Sequence: MEPQVTLNVTFKNETQSFLVSDPENTTWADVEAMVKVSFDLNTIQIKYLDEENEEISINSQGEYEEALKMANIKQGNQLQMQVHEGCHVVDEVLPQTVVEKQATARTGKKPLAHYSSLVRVLGSDMKTTEEPTAEARSPVPCDTDKPQDKPPDWFTSYLEMFREQVVKETVEKLEQRLQEKLVLQKPPFSSSPSEVSMPISEEETLFLPENQFSWHIACSHCQKRIVGVRYQCSLCPSYNICEDCEAGPYSHDTNHILLKFRRPVVISSEPFFYSKYPTPRLPAALEQVRLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCAPVMPTLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWSADTKLKFMWGNLTLASTEKKDVLVPCLKAGHIGVVSVEFIAPTLEGTYTLHWRLSHKGQQFGPRVWCSIIVDPFPSSESPVNLERDGISSSKADDFTCEQEEAFLLAEEEIPLGEVTKQTEGTGSSAPQKTQHAASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDVTPRMSPLPHDSPLIEKPGLGRIQEESEGAGLKASPDSTVLTKRKAETPASVEETEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQRSPQRELQLYSTEEQQPLMLPGFCRKDSSLKFALPEEGPHGDEREEIVHIAEEEAIEEEDVQDEEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGEPGIESGQEPAEARERLPERESQPKEQSISDILTTSQHLDTVPLVPEVAGLPAALSRSAPCGQYEAPRVDSPVTIQEVLPVPDHVRGEPRGSTGLANSRQKSCDHSRHHNGSSIAGGLVKGALSVAASAYKALFSGPPVTAQPVISEDQTAALMAHLFEMGFCDRQLNLRLLRKHNHNILQVVTELLQVNNNDWYSHRY
What is the function of this protein?
Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis.  Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates.  Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity).  In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity).  In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity).  Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity).
What are the official names of this protein?
Next to BRCA1 gene 1 protein, Neighbor of BRCA1 gene 1 protein.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line. Note=In cardiac muscles localizes to the sarcomeric M line (PubMed:15802564). Is targeted to lysosomes for degradation (By similarity).
Protein: TETR4_SALOR
Sequence: MARLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPAAPDENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIVGGDKLIIPFC
What is the function of this protein?
TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA.  Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
What are the official names of this protein?
Tetracycline repressor protein class D.
Protein: C2AIL_HUMAN
Sequence: MVGGEAAAAVEELVSGVRQAADFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGSGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKHQS
What are the official names of this protein?
CDKN2AIP N-terminal-like protein, CDKN2A-interacting protein N-terminal-like protein.
What is the protein family that this protein belongs to?
Belongs to the CARF family.
Protein: ANMK_SYNS3
Sequence: MRVLGLMSGTSADGVDAVLVELSGSADHPRWSLLRSASLDYPTSTRQLILAVGQGEAKTASSLLNLSETITKIQAAAALQCDPEEQAQLVGCHGQTLWHRPPKRAGTGELQRGASWQMLQAPLLAQLLNRPVIFDFRAADLALGGQGAPLVPKADAALLGRTKGWRALLNLGGIANLTLIPPDAGPDRLQPVRGWDCGPANSLIDLAMEQFSEGEESCDQGGRLAETGHCDEALILRWLAEPYFQLNPPKSTGREVFGRADLTRRLRDMQGQPIANQIATLTAFSAAVVAQDLQQLSNQNHPLPIELVVAGGGSKNLTLMRELNTRCRGLRLRRSDELQLPSQSREAMVFALLAWWHHLGYPGNAPAITGAQHEVVLGVRVNPA
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RECR_LEPIC
Sequence: MAENLANHLLDEMIEALSSLPGIGRKSAFRISFHLLRLEQGLFNQFIHQLTDTKNKIKFCKRCGSYAETEICEICVSEKRDSHTFCVVEQPEDIFFIENTREFQGKYHVLNGVISPLEGIGPRDLRIKELLERIEPEQVKEVLIATNPTLEGDATADYLANQLKPISVNVTRIAYGITVGGSIELADQYTLGRAIRSRLQL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: URK_PSYIN
Sequence: MDSKNCVVIAIAGASASGKSLIANTIYQELCEELGTNQIGMISEDSYYRDQSHLELELRKLTNYDHPKAFEHELLCSHLKMLKENCSVNIPVYSYTEHTRTLESETMTSKKVIILEGILLLNDSALREQIDVSIFIDTPLDICLMRRLVRDMAERERTMDSVLLQYTKTVRPMFLQFIEPSKQHADIIVPRGGKNRIAKDLLKTRIKYLLGK
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP135_MOUSE
Sequence: MTTAAERKYINIRKRLDQLGYRQTLSVDSLPLVEKLFSDLVHTTESLRQCRLSSGKAEKESANLDFVLEPYKLENTRLNKENNELYLELMKLRECSDKHIKDLKTTLKKCSRETADLKFLNNQYVHKVKVLEKESKAKDEKIQQLQEKNLRAVVQTPGGRKRNIAFRRQRMQIDEPAPPSEVSAYPVPQPEDPYIADLLQVADNRIQELQEEVQQLQEKLAQMEKGVLDYSKQIELREREIQRLSLALDGGCSPDVLSLETRNKTNEKLIAHLNVQVDFLQQANKELEKHIQELMETKETVTTEVVNLSNRNEKLCQELTEIDQLAQRLERHKEQVLETADKELGEAKKEIKRNLCEMRNLEEKMSKLQWELDLSHKEKERLNSELLLKSDLETVVHQLEQEKQRLSKKLQSFAVTERELTLEVERMRLEHGIKRRDKSPSRLDTFLKGIEEERDYYKKELEKLQHLIQRRSCAINYSAREKPPVVKCSEKGDCSTDVHLITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLNVLYKEAKEELSTLRKESTNSTSPNHLVSCVEKEKERALSELRRITAEKEALREKLKNIQERNAVGKSDLEKTIEHLTYINHQLENEKYELQSKMLMMKETVESLENKSKLQAQKLSHVTGDSSHQKTEMTSLRIVSEQLQRSLDDCQHRLSIKRGELESAQEQIKMLEQKLENLSHRMTVQSEETHAMKKTIGVMDKEKDFLQETVDEKTEKIANLQESLLSKEKVIAQLKVTVAEYETSLNQLQETLTTRDREINSLRRQLDASHKELDDVGKSREISFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENKDLLDRFQMLHSRAEDWEVKAQQAEGENSSVRLELLSIDTERRHLRERVDLLEKEIQEHINAHHAYESQISSMAKAMSQLEEELRRHESEKATMLGDVSSLRELCIKLDSGKDVMTQQLNSKSLELERAVAELENVKSESELLKKQLTNERQTIKNLESLLATNRDKEFQSHLTSHEKDTEIQLLKEKLNLSESKLTTQSRETSMLRTKVTQLQTDYDNLKRQMSNEKYERERAIQEMRRLGLPTSPLSSTLKSPVQTPDHINA
What is the function of this protein?
Centrosomal protein involved in centriole biogenesis.  Acts as a scaffolding protein during early centriole biogenesis.  Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles.  Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole.  Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity).
What are the official names of this protein?
Centrosomal protein of 135 kDa, Cep135, Centrosomal protein 4.
What is the protein family that this protein belongs to?
Belongs to the CEP135/TSGA10 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
Protein: ENGB_BRADU
Sequence: MTDDKDAKLIEAGRKLFARDWQFIWASPSIQTLPPMDGVEIAFAGRSNVGKSSLINALTGRNALARTSHTPGRTQELIFFEVPGKKDLRLVDMPGYGYAKAPKSQVASWTELIHKFLLGRASLARVYVLIDARHGLKDVDLEILGTLDRSAVSYQIVLTKADQVKPSELASRIAETEAALAKHPAAFPNVLATSSRSATGMAELRAAMAKLLEERSS
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: ACOA_CUPNH
Sequence: MTARASQDSAALPLDKETLLTVYRKMRTIRDFEERLHVDFGRGDIPGFVHLYAGEEAAGVGILHHLNDGDRIASTHRGHGHCIAKGVDPVAMMKEIYGKKGGSCNGKGGSMHIADLSKGMMGANGILGAGAPLICGAALAAKFRGKGEVGITFCGDGASNQGTFLESLNLAAVWNLPVIFVIENNGYAESTSRDYGTAVDSYVDRAAGFGIPGVTVDGTDFFAVHEAAGEVIRRAREGGGPSLLECKMVRFYGHFEGDAQTYRAAGELDDIRANKDCLKLFGRAVTQAGVVAREELDTIDREVAALIEHAVQEAKAAPQPGPEDLLTDVYVSY
What is the function of this protein?
Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde, in vitro.  The alpha subunit is probably the catalytic subunit of the enzyme.
What are the official names of this protein?
Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha, Acetoin:DCPIP oxidoreductase-alpha, Ao:DCPIP OR.
Protein: RS6_GLUDA
Sequence: MPLYETVFIARNDVSQQQVEAVADGIAALLETDGGAVKKREYWGLRSLAYRIKKNRKGHYMLLGLDAKPETIKEIERQLGLNEDVMRVLTLRVDEIDEAPSVILSRKGDERERGFRGPKPAGRFESGRGGAGGARRGYDDREEFRARNEREDGRDTDGEAE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RS4_NEOSM
Sequence: MTTTIRRKFRVSRQMKASLWGSQKDPVHKRNYAPGQHGRAPVKKISDFYKQNAAQRAFRTYYVIGKKQFANVFSKAYRGKGNTNDNLISLLESRVSSVLYRSGMVPTIFAARQLISHKHVTVNGEIVNICSFTLKEGDVVQIRDRASNIPCVVAALNSNSESPHYLEVDREKRSVKLLVLPKFEDVPYPVVMEPNLVTEYFSSKM
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: ACR7_CAEEL
Sequence: MMVQSIQIVLPVALFFLIVFNGFTVEGSKKEAQLYRDLLTNYSYLVRPVRNPKKALTVTMKVFIQQVLLVDAKHQMIEVNAWLKYIWTDFRLRWNPLDYENITSVRFQGEDQIWQPDILLYNRYIEDEQESFDITYKTNAVAYSDGVINWIPPGIFKLSCKMDITLFPFDEQICFMKFGSWTYHGFALDLRLDVVKGQEPSADLSTYITNGEWHLLSAPARREEKFYKCCKEPYPTVKFYLHLRRRTFYYVFNVVLPTLLVSFMSLLAFCLPATDLSEKIGLQTTILLSVCFFLTILSEMTPTTSEAVPLLGVFFSALTFIVAMSTTFTILVLNIRYRQITNHYLSPMFRSIFLECLPWLMMMKRPDHKFRRGSSYRDSSADQCVQCAKNAELKSILRGTDNQQQIETNTFYPFPTETLSLNRKVGDGLFIQRRCQIHEEARSEKFTHGMLACEKSLRENGSELANILVTILKMYEVMVSQVERIRKRIALKRKRKDIQDEWKFAAQAVDRFCLIIFTIVFIICCFIFVAIPPIKILD
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit alpha-type acr-7.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: SYM_ECO27
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKAPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYKTFTDAAEVIGEAWESREFGKAIREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMKQVEALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDAGAKPGHQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2435_PHOPR
Sequence: MSESFQNKAFKTKIVFDEAKPTDSDAELTAQVQFAESNTFLPEVKADDDIEEQLSHTLASKTKKRSSWFKGLLIAGAAMTGWQTVDYVVSAYQTGDWLALGWSVIVAGIATMGITALGRELFKLRRLKQRQTEREQAQVLLDADGIGQGKAFCMKLAKLSDIRDEHAGYDRWVQSLAATHNDREVLELYDQMVLSHQDRLSRQLVAKYSSEAAVMVAMSPLAVADMLLVAWRNFKLIEQVSVVYGVELGYWSRIKLVKLVLANMAFAGATEVIADTGMDMLSMDLAGRVSTRVAQGVGVGLLTGRLGLKAITLMRPLPWQPDQQPKLSEIRRDLLLKLTHKNESSKNN
What are the official names of this protein?
UPF0283 membrane protein PBPRA2435.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RM54_HUMAN
Sequence: MATKRLFGATRTWAGWGAWELLNPATSGRLLARDYAKKPVMKGAKSGKGAVTSEALKDPDVCTDPVQLTTYAMGVNIYKEGQDVPLKPDAEYPEWLFEMNLGPPKTLEELDPESREYWRRLRKQNIWRHNRLSKNKRL
What are the official names of this protein?
39S ribosomal protein L54, mitochondrial, L54mt, MRP-L54, Mitochondrial large ribosomal subunit protein mL54.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL54 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UBE4_ARATH
Sequence: MATSKPQRSPAEIEDIILRKIFYVTLTESTDSDPRIVYLEMTAAEILSEGKELLLSRDLMERVLIDRLSGDFSDAEPPFPYLIGCHRRAYDESKKIQSMKDKNLRSEMEIVTKQAKKLAVSYCRIHLGNPDMFGNSDKPSGGLDNRLKKRNVSPVLPLIFAEVGSGSLDMFGASSSGVQAPPGFLDEFFKDSDFDSLDSILKELYEDLRSTVINVSVLGDFQPPLRALKYLVSLPVGAKSLVSHEWWVPRGAYMNGRAMELTSILGPFFHISALPDNTLFKSQPDVGQQCFSEASERRPADLLSSFSTIKNFMNILYSGLHDVLMILLKSTDTRERVLQFLAEVINANASRAHIQVDPVSCASSGMFVNLSAVMLRLCEPFLDPHLTKRDKIDPKYAFCGHRLKLSDLTALHASSEEVTEWIGKDAMANANDAGRENGNESRLLQSKEATSSSSNASGQNAKSATKYTFICECFFMTARVLNLGLLKALSDFKHLAQDISRGEDNLATLKAMRDQAPSPQLELDISRMEKELELSSQEKLCHEAQILRDGDFIQRALSFYRLMVVWLVGLVGGFKMPLPSTCPMEFSCMPEHFVEDAMELLIFASRIPKALDGVPLDDFMNFIIMFMASPEYVRNPYLRAKMVEVLNCWMPRSSSSSSATSTLFEGHQLSLEYLVRNLLKLYVDIEFTGSHTQFYDKFNIRHNIAELLEYLWQVPSHRNAWRRIAKDEEKGVYLNFLNFLVNDSIYLLDESLNKILEIKQIEADMSNTAEWEQRPTQERQERTRLFHSQENIVRIDMKLANEDVTMLAFTSEEITAPFLLPEMVERVANMLNYFLLQLVGPQRKSLSLKDPEKYEFRPKQLLKQIVRIYVNLARGDTVNIFPGAISSDGRSYNEQLFNAGADVLRRIGEEGRIIQEFMELGTKAKAAASEALDAEAALGEIPDEFLDPIQYTLMRDPVILPSSRITVDRPIIQRHLLSDNHDPFNRAHLTSDMLIPDIELKAKIDEFVKSHQSKKRTSGEDSSNKERIQTTNSDMLID
What is the function of this protein?
Ubiquitin-protein ligase that may function as an E3 ligase in conjunction with specific E1 and E2 ligases.  May also function as an E4 ligase mediating the assembly of polyubiquitin chain assembly on substrates monoubiquitinated by another E3 ubiquitin ligase.
What are the official names of this protein?
Probable ubiquitin conjugation factor E4, Plant U-box protein 1, RING-type E3 ubiquitin transferase E4, U-box domain-containing protein 1, Ubiquitin-fusion degradation protein 2-like, UB fusion protein 2-like.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin conjugation factor E4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CLP1_HUMAN
Sequence: MGEEANDDKKPTTKFELERETELRFEVEASQSVQLELLTGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSVQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGSGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDLEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK
What is the function of this protein?
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids.  dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component.  Plays a key role in both tRNA splicing and mRNA 3'-end formation.  Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810).  Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810).  Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation.  Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC).  However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
What are the official names of this protein?
Polyribonucleotide 5'-hydroxyl-kinase Clp1, Polyadenylation factor Clp1, Polynucleotide kinase Clp1, Pre-mRNA cleavage complex II protein Clp1.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HTPG_CUPTR
Sequence: MTAPHETMSFQAEVKQLLHLMIHSLYSNKEIFLRELVSNASDATDKLRFEAIANPSLLENDADLAIRIEADAKARTLKITDNGIGMSRDEAIRNLGTIARSGTKEFFQQLSGDQQKDAALIGQFGVGFYSAFIVADKVTVETRRAGLGAEEAVRWESTGDGEFTVDAIARAERGTTITLHLREGEDDFLSAWRLKSIIQKYSDHISLPIRMPKEVWDAEASTYKRTDEWESVNQASALWTRAKSDITDEQYTAFYQHIAHDNEAPLAWTHNRVEGRSEYTQLLYIPARAPFDLWDRNHKAGLKLYVKRVFIMDDAEQLLPGYLRWVKGVVDSADLPLNVSRELLQESRDVKAIREGCTKRVLSMLETLADSEDEAERAKYATFWQQFGQALKEGVGEDQANQERVAKLLRFASTHNDTAEQNVALAAYVGRMKEGQDKIYYVTADTWSAAKNSPHLEVFRKKGIEVLLLTDRVDEWMLSYLREFDGKELVSVARGDLDLGKLADEAEKAEQEKAEADWKDVIERARAVLAGKAKDVRVTLRLTESASCLVSDEGDMSGYLQRLLKQAGQKAPDAQPILELNPEHALVKKLRDLPEGEAFSDRLQVLFDQALLAEGGMLEDPAAYVQRVNKLLA
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATD_CAEEL
Sequence: MSGGGKDRIAVFPSRMAQTLMKTRLKGAQKGHSLLKKKADALNLRFRDILRKIVENKVLMGEVMKEAAFSLAEAKFTAGDFSHTVIQNVSQAQYRVRMKKENVVGVFLPVFDAYQDGPDAYDLTGLGKGGANIARLKKNYNKAIELLVELATLQTCFITLDEAIKVTNRRVNAIEHVIIPRIENTLTYIVTELDEMEREEFFRMKKIQANKKKLKEQEAAQKALEGPGPGEDAAHSENNPPRNLLASEEDNLPVLFN
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit D, V-ATPase subunit D, Vacuolar proton pump subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: COQ6_DROME
Sequence: MLGVLRIQGALASAGQARLLSVRLLASKSTTDMTTNRGESTQSTSTEHFDIIIGGGGLVGTTLAAALAKNSTLADKKVLLLEGAPEFRGFNPTGPYQNRVSAINHNSIELFKSIDAWKHIESARYKPVKQMQVWESNTDALIQFQHDNFASDVACIIENDLILDAVYALAKESPNVEILNKARIQCVRLPRDSNSNHSELQLEDGRNFSCDLLIGADGANSVVRKEMNVDVFSLNYDRMGLVATLELGEDACDNSVAWQRFLPNGPVALLPLTDRLSSLVWSTTNEQAKMLQALPPTEFVDALNEAFCRQYPRVELADKAVQALNSLFGHNGSQHQVQYPPRVCGVLDKSRATFPLGFLHASSYVCNGAALVGDAAHRVHPLAGQGVNLGFSDVRYLVESLAAGAYAGFKLGDKQHLIKYERKCLAKNVPIMLGVHGLHTLYATQFSPVVLLRSLGLQLTQNLPPVKNLFMRGAMGQ
What is the function of this protein?
FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis.  Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid.  The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
What are the official names of this protein?
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the UbiH/COQ6 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: MSRA_HUMAN
Sequence: MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKVLSEHGFGPITTDIREGQTFYYAEDYHQQYLSKNPNGYCGLGGTGVSCPVGIKK
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Mitochondrial peptide methionine sulfoxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase, Protein-methionine-S-oxide reductase, PMSR.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
What are the subcellular locations of this protein?
[Isoform 1]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm. Membrane; Lipid-anchor.