PharMolix/UniProtQA huggingface dataset:
Protein: SYN_LIGS1
Sequence: MKTISIIDAKHHVNEKVKIGVWLTNKRSSGKIAFLQLRDGSAYFQGVVVKNAVSEETFALAKEVKQETSLYVTGVIHEDKRSHFGYEIEIEEIEVVGESNEYPITPKEHGTDFLMDHRHLWLRSKKQFAIMQIRNEMIRATYEFFNKEGFIKLDAPILTGSAPEGTTELFHTEYFDRDAYLSQSGQLYEEAGAMAYGKVFSFGPTFRAEKSKTRRHLIEFWMIEPEMAFMHQEESLEIQERYVAYLVQSVLDNCQYPLQILGRDTEVLKRYTELPYPRISYDEAIELLQQSGKFPDVKWGEDFGSPEETYLAEHFSKPVFVMNYPKAIKPFYMKPHPTRDDVVICADMLAPEGYGEIIGGSERATDPKYLEEQIIKAGLDVKDYEWYLDLRRYGSVPHSGFGLGLERAVTWITGEDHIREAIPFPRLLNRIYP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_LACCB
Sequence: MDVHDVKLTISAVAAAQYPEDGHPEIAFLGRSNVGKSSLINKLIQRKAMARTSGVPGKTQTLNFYDLDSRLFFVDVPGYGYAKVSKTARAKFAAMIETYLTTRQPLRGVVLLVDSRHEPTADDISMYQYLKYYQLRTLVVATKIDKTPKSKRLHVAKQIKQRLDLNQTDDVILFSATTGEGYEAVWSWLEQTAGLEGR
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: Y5849_AGRVS
Sequence: MIALKHLAHWDVEPARAARARYRSGDVEPTSGVAPGFTQANMIVLPRDWAFDFLLYAQRNPKACPVLDVSDPGSHLTELAKGADLRTDLPLYRIWRDGKLAEETPDATAAWAEHPDLVSFLIGCSFTFETPMVEAGIEIRHMTDKSNVPMYLTNQPCRPAGRLHGNMVVSMRPIPASRVADAATISGRFPAVHGAPVHVGAPEQIGIVDLAKPQFGDPVRIEPGEVPVFWACGVTPQAAVMASGVPFAITHAPGHMFITDILDSAYHA
What are the official names of this protein?
Putative hydro-lyase Avi_5849.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: CCF1_ENTFL
Sequence: LVTLVFV
What is the function of this protein?
cCF10 is involved in the conjugative transfer of the hemolysin plasmid pCF10.
What are the official names of this protein?
Sex pheromone cCF10.
Protein: RPOC_XYLF2
Sequence: MKDLLNLFNQQRQTLDFDAIKIGLASPALIRSWSFGEVKKPETINYRTFKPERDGLFCAAIFGPIKDYECLCGKYKRMKHRGVVCEKCGTEVTLAKVRRERMGCIELASPVAHIWFLKSLPSRIGLMLDMTLRDIERVLYFEAYVVTEPGLTPLERRQLLTEEQYLQARQEHADDFDASMGAEAVYELLRMIDLQSEMARLREEIVVTGSETKLKRLTKRIKLIEAFIESGNRPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLCRLLELSAPDIIVRNEKRMLQESVDALLDNGRRGRAITGTNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSARSVIIVGPNLRLHQCGLPKKMALELFKPFVFAKLQRRGLATTIKGAKKLVEREEAEVWDILEEVISEHPVVLNRAPTLHRQGIQAFEPVLIEGKAIQLHPLVCTAFNADFDGDQMAVHVPLSLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMSRALENKKGEGMVFANTSELKRAYDNSVVELHAKVKVRITEIETDDQGLRNKASSIVDTTVGRALLSEILPEGLPFVLVNTEMTKKNISRLINSSYRMLGLKETVVFADKLMYTGYAYATRAGVSICIDDMLIPIEKKEILGEAEQEVLEIQEQYQSGLVTAGERYNKVVDIWSRTNERIAKAMMDTIGTERVVNADGEIVDQKSMNSLYIMADSGARGSPQQIRQLAAMRGLMVRPDGSIIETPIKANFREGLSVQEYFNSTHGARKGLADTALKTANSGYLTRRLVDVTQDLCVVQLDCGTAGGLTMTPIVEGGDVVEPLKDRVLGRVVAEDVLLPGNDDEPIVTRSTLLDEQWVAKLEEAGVQSVKVRSPITCESPFGVCALCYGRDLARGHLVNMGEAVGVIAAQSIGEPGTQLTMRTFHIGGTALSAAAIDNITVKTSGSVKFTNLKYVEHANGTLVAVSRSGEISVLDTHGRERERYKLPYGATINVKDMAEVKSGQILANWDPHNHPIVSEVAGFVRFIDFVDGVTVIEKTDDLTGLSSREIADLKRRGSQGKDLRPLVRIVDKKGNDLTIPGTDLSAQYLLPPRSIVNLQDGAPVGIGDVVAKIPQEASKTRDITGGLPRVADLFEARRPKDPAILAERSGVISFGKDTKGKQRLIIKDADGSEHEELIPKYRQIIVFEGEHVTKGETIVDGEPSPQDILRLLGIEPLAAYLVKEIQDVYRLQGVKINDKHIEVITRQMLRKVEIVDQGNSKFLNGEQVERQRVIDENAKLIARNELPAKYNPVLLGITKASLATESFISAASFQETTRVLTEAAVRGTRDNLRGLKENVIVGRLIPAGTGQTYHSQRRYSSVGLTESEMETLVGRSTSSGTEVTSPSKDAIPLGG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RFRNP_METBF
Sequence: MLKQRFVLDTTALTDLQTREVMGYASLCEGMKAILDLIADARLHFGISCYVPYPSVYKEMYEFASRNGCDREVVAKIDTWLVKKSPDRYRVSVTSQIFHEYVAYMRERINRGMGVAEDAIWEAATECLFMENPQNKKKEYKEEVEREVIGGIIGKFRNKYRAALRYGILDSAPDIDVLILAKELDAAVIASDYGIEKWAEQLGVRFVPANVFPMMIQEYLKHLPENENEPEYENRDKSKEGSSGEIEFI
What is the function of this protein?
RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.
What are the official names of this protein?
RNA-free ribonuclease P, RNA-free RNase P, Protein-only RNase P.
What is the protein family that this protein belongs to?
Belongs to the HARP family.
Protein: IXTPA_STRPN
Sequence: MLIATRNEGKTKEFRAIFDKLGYDVENLNDYPDLPEVAETGMTFEENARLKAETISQLTGKMVLADDSGLKVDVLGGLPGVWSARFAGVGATDRENNAKLLHELAMVFELKDRSAQFHTTLVVASPNKESLVVEADWSGYINFEPKGENGFGYDPLFLVGETGESSAELTLEEKNSQSHRALAVKKLLEVFPSWQSKPSL
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: ECL1_SCHPO
Sequence: MDLDFCTVCGATTQDGSLYCSSECHLLDFTKLDTQTTSNISVSSEYQFLVSEHLAHFHRKSMTSADFPTPRFSAYTKLHA
What is the function of this protein?
Involved in chronological cell aging.  Extends cell viability after entry into the stationary phase probably through affecting the Pka1-dependent pathway negatively.
What are the official names of this protein?
Extender of the chronological lifespan protein 1.
What is the protein family that this protein belongs to?
Belongs to the ecl1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OS9_ASPFU
Sequence: MIRRIRTLTPLLVLACAGSGAWASKKAFNIQDDLLAYPQFQVFFPDEYILDARARELLQNQQESSSASADKTFSEGNDAQVYLGSRKDQSEDVNKETIEGSGFTYEEMLLEGQRYLCSIPQVDNGNRDQTNGAESTSKEDEQREIARATDRGLELLREMEGKCMYYISGWWSYSFCYKKQIKQFHALPSGPGVPNYPPIEDSTTHSFVLGRFPNSGDDEDLEGDAEHKKTTTDVAELQTKGGSRYLVQRLGGGTKCDLTGKDRKIEVQFHCHPQSTDRIGWIKELTTCSYLMVIYTPRLCNDVAFLPPQQDEAHAIECREILSEEEVSDWEANREYHLAQQLVESAITPEFPVVGDIEVGAHKWVGSEGKQIEKGRVASIGEEKIEVVAKRQNGEITRLSKEELKKYGLDPEKIETLKSRLEELAKGKDWTLEIVESNGERGLVGTVDSNDDEKEDHAAQGSISQPAQGTTADKGESNAETGEEKKKADEKIDHYEPEKSGPTTDDADDGSEEIFFKDEL
What is the function of this protein?
Lectin involved in the quality control of the secretory pathway.  As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).
What are the official names of this protein?
Protein OS-9 homolog.
What is the protein family that this protein belongs to?
Belongs to the OS-9 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Protein: TRUA_BURVG
Sequence: MRIALGVQYDGAAFCGWQAQPHGKTVQDALERALGEFACVPLHTTVAGRTDTGVHGLGQVVHFDTALDRAEFSWVRGTNAFLPPTVSVQWAKAMPDTFHARFSAFERTYYYALYVHPVRSPMLAGRAGWIHTPLDDDAMRAAAVHLIGEHDFSSFRSSECQSKTPVKHLYQIDVRRSGHFIHFRFRANAFLHHMVRNLMGCLVAVGRGRYPADWLADVLAGRDRNLAAPTFMADGLYLAHVGYPAEFAVPPAQLGSVPWSSVWADLDPQP
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: RF2_STRGC
Sequence: MDISEIRQKIDANREKLASFRGSLDLEGLEEEIAILENKMTEPDFWDDNIAAQKTSQELNELKQTYENFHQMTDLFDESEILLDFLAEDDSVQEELEEKLAELEKMMTSYEMTLLLSEPYDNNNAILEIHPGSGGTEAQDWGDMLLRMYTRFGNAKGFKVEVLDYQAGDEAGIKSVTLSFEGPHAYGLLKSEMGVHRLVRISPFDSAKRRHTSFTSVEVMPELDDTIEVEIREDDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPTGIVVQSTVDRTQYGNRDRAMKMLQAKLYQLEQEKKAAEVDSLKGDKKEISWGSQIRSYVFTPYTMVKDHRTSYEVAQVDKVMDGDLDGFIDAYLKWRLN
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_CAMC5
Sequence: MQVCGIDEAGRGALAGPMAVAACVLNAGISGLNDSKKLTPKRRKELFHLITQNSRYLIVYFSNEQIDELGLSECLRRALNLFKLYFAGCELLYDGNQNYGTGVQTMVKADAKVEEVGAASILAKVSRDELMCAWDKIYPNFGYKSHKGYGTKAHLEAITKYGQNEISRKSFVIKNFQPSLELF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_HALHL
Sequence: MAKRRGGRNVTGVLLFDKPAGVTSNKALQQVKRLFGARKAGHTGSLDPLATGLLPICFGDATKVSGFLLDADKRYVVTCKLGVATDTGDAEGTERDRAEVPALDEEAVERGLTGFRGPIDQLPPMYSAIKHQGQRLYDLARQGVEVEREPRRVEIYDLQLVAVRGDELELSVHCSKGTYIRTLAEDIAQALGTVGHVCALRRLGLGPYQDPAMWTEEMLAARAEQGREALDATLLPMDSALQQYTGVELADDLAYFVVQGQPVFVPKAPSEGWLRLYDRGGNFLGMGQALDDGRIGPKRLVARR
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RS4_ACIC1
Sequence: MARYLGADCKLCRREKMKLFLKGSKCESPKCPIEERPYPPGEHGRTRAKESEYLLQLREKQKCARIYGVLEKQFRRYYEEASRKTGRTGENLLRILESRLDNVVYRAGFAASRDQARQLVRHGHFLVNGRRVDIPSYRVSENDVIEVAEKSRELTPFVIARAVAGERTVPPWLEVIPNRLRILVHSLPSRQVIDTPVQEQLIVEFYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: DNLJ_BORBZ
Sequence: MSSKVQQEIADLKKLIRKWDKEYYVDSLPSVEDFVYDKHILRLQELESKYPEYKTLDSPTLKFGSDLLNDFKEVEHSAPILSLDKVYDLDLLKSWIDKIDFNNSFNISVEPKIDGCSIVLYYKDGVLEKALTRGNGKFGNDVTINVRTIRYIPLFLDEKVDLVLRGEVYITKENFLKINKFLEKPYTNSRNLASGILRRVDSREVANFPLNIFIYDFLNAGLEFKTNDLATARLKKLGFKVNPLIRFFDLKNSIGEVLNYIADIIKKRDSFEYEIDGVVLKVSDFALRERLGYTAHHPKWAMAYKFEALSDFSRVNSIVVQVGRSGKITPVANIDKVFVSGAFITSATLHNQDYIRSIGLNVGDVVKVSRRGDVIPAVEMVINKFSTGFFKVPDNCPACKTAVVKEGAHFFCPNNNCPSVAVERIKYFCSKNCMDIEGFSDKIISFLFEKKFIFSEIDLYTFDFYKLLEFKGFKDRKINNLINSIEASKKKPFSKLLLSMGIKDLGENTIMLLFLNNLNSFSKLFKLCQDRYFAFSTLLKIKGIGEKIALNIIEAFNDSVMLNKFKFFENLEFKMEEVVAIDGENKLLAGKKFCITGTFNGYSRSIVIDKLKNKGAIFNTCVTGSLDFLIVGEKAGSKLKKALSLNIKIMSFEDIKSYLD
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RNC_SHEB8
Sequence: MEPIKNLPRLCRTLGYEFKNIELLTQALTHRSAANKHNERLEFLGDSILSIVISDALYHQFPKATEGDLSRMRATLVRGDTLTIIAQEFKLGDYLYLGPGELKSGGFRRESILADAVEAIIGAVYLDSDLEVCRALLLKWYAERLAEIQPGISQKDAKTLLQEHLQGFKKPLPDYQVINIEGDAHDQTFTVECRIEDLSQSVIGVASSRRKAEQIAAAQVLELLKK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2270_ARCFU
Sequence: MEPAIGICNLGGTAESRVVFEPVILTKEDIAEIFSDKKSKKFLSHIKFVDFDKMKGELILIDDGVVAVCRQRQENKVFVLVKIIGKEEDFLMAYEVEDSSYRIYLESSCSEISVSKFCRNSACWAVPVYILFPSL
What are the official names of this protein?
Uncharacterized protein AF_2270.
Protein: PSB_HALSA
Sequence: MFNPNNGSEFARNRARLDDTPNPYEPEVGSLPEGDRSQAGSDTVNKTGTTIVGLTTQDGVLMASDMRASLGGRVISNKNVQKVEEIQPNAALSISGSVGGAQSFIRSLRAEANLYEARRGEYMSIDALSTMASNLLRGGPFFRVVPILGGVDDDGGHVFSLDPAGSSMSDTYTAQGSGMPYALGVLEQEYSEDLTMADAEQVAAHAVKSASERDTASGNGIHITKITHDGLTTVGHKEFDALL
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PsmB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_BACP2
Sequence: MLDIKQLRTDFDQIKEKLAHRGEDLADFDKFGELDQKRRELIGKTEVLKSRRNEVSQQVAVLKREKKDADHIIQEMREVGDEIKKLDDELRTVEESLQHILFSIPNIPHDTVPVGETEDDNVEVRKWGEQPAFSFEPKPHWDVADELNILDFERAGKVTGSRFVFYKGLGARLERALYNFMLDLHVDEFGFTEVLPPYMVNRASMTGTGQLPKFEEDAFKIREEDYFLIPTAEVPITNMHRDEIIEGEQLPINYAAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVKFVRPEDSYEELEKLTNQAEKVLQLLNLPYRVMSMCTGDLGFTAAKKYDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRPEPKAKPEHVHTLNGSGLAVGRTVAAILENYQQEDGTVIIPEVLRPYMGNKEVMK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNG1_HUMAN
Sequence: MEGGAYGAGKAGGAFDPYTLVRQPHTILRVVSWLFSIVVFGSIVNEGYLNSASEGEEFCIYNRNPNACSYGVAVGVLAFLTCLLYLALDVYFPQISSVKDRKKAVLSDIGVSAFWAFLWFVGFCYLANQWQVSKPKDNPLNEGTDAARAAIAFSFFSIFTWAGQAVLAFQRYQIGADSALFSQDYMDPSQDSSMPYAPYVEPTGPDPAGMGGTYQQPANTFDTEPQGYQSQGY
What is the function of this protein?
May play a role in regulated exocytosis.  Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity).  Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
What are the official names of this protein?
Synaptogyrin-1.
What is the protein family that this protein belongs to?
Belongs to the synaptogyrin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein: RPPH_SODGM
Sequence: MIDDDGYRPNVGIVICNLDGQVLWARRYGQHSWQFPQGGINAGETAEQAMYRELFEEVGLSRKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFLLQLLCPDADINMQRGGIPEFDGWRWVSFWYPVRQVVSFKRDVYRRVMKEFSGVVMPLQETAAQRSASAHRRKRG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: PO113_HUMAN
Sequence: NKSRKRRNRVSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLIIIDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRALQPVRDKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHYLGMQIENRKIKPQKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYVMSNLFSILRGDSDLNSKRMLTPETTKEIKLVEEKIQSAQINRIDPLAPLRLLIFATAHSPIGIIIQNTDLVEWSFLPHSTVKTFTLYLDQIATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAWQIGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRREPLENALTVFTDGSSNGKAAYTGLKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYVVQATRDVETALIKYSMDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEQADLLVSSALIKAQELHALTHVNAAGLKNKFDVTWKQAKDIVQHCTQCQVLHLPTQEAGVNPRGLCPNALWQMDVTHVPSFGRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAFQKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLAPYTLNFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSPGENQLPVWMPTRHLKFYNEPIGDAKKSTSAETETPQSSTVDSQDEQNGDVRRTDEVAIHQEGRAADLGTTKEADAVSYKISREHKGDTNPREYAACSLDDCINGGKSPYACRSSCS
What is the function of this protein?
Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA.  The RNase H domain of the reverse transcriptase performs two functions.  It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid.  Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome.  Endogenous Pol proteins may have kept, lost or modified their original function during evolution.
What are the official names of this protein?
Endogenous retrovirus group K member 113 Pol protein, HERV-K113 Pol protein, HERV-K_19p13.11 provirus ancestral Pol protein.
What is the protein family that this protein belongs to?
Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.
Protein: MDFA_YERPZ
Sequence: MQTSFSPATRLGRRALLFPLCLVLFEFAAYIANDMIQPGMLAVVAEFNASVEWVPTSMTAYLAGGMFLQWLLGPLSDRRGRRPVMLAGVAFFVVTCLAILLVNSIEQFIAMRFLQGIGLCFIGAVGYATIQESFEEAVCIKITALMANVALIAPLLGPLAGAALIHVAPWQTMFVLFAVLGAISFAGLWRAMPETASLKGEKLSVANMWRDYKQVLANRRFLCGSLALGFASLPLLAWIAQSPVILISGEQLSTFEYGILQVPIFGALIIGNLTLARLSGKTSIPQLIRYGAGPMIVGLMIAAGSTLYSSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDISKGTVSAAMGMISMMIFTLGIELAKVAYLWGDSRGFNLFNLMSGLLWLGLVMVFIRRQPEAVATE
What is the function of this protein?
Efflux pump driven by the proton motive force.  Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity).
What are the official names of this protein?
Multidrug transporter MdfA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. MdfA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AEP1_YEAS1
Sequence: MITTVQEINKWRNLCFIRMQSRKWYPVLKKTPLVADGRKIIKHADKVPHPGEIIHPFYQPTAIEQFTACATEYNPSLLDGKKIAPSLIKHPVSLKTILVDSKLKFDDIRGVNRWLMEFVARRQHQRNIVLTPASKSVRSFHVLHLSSTDIAKLRGLENVLSEIENTNDLQSRVESVNNELQNIFDRDSKQTRLFCEDILAYLIKNYGNSTENLILLINVTEMQLFSRLDQMKAMNIILYHILCKVEANENPPYSPTLVTALENLLAAINNRFFPGRCENSLHPIVIEQLLSYFIITGNLNESKNFLGHLIKKGILPEATIINRYLEAIDVHFDKSTKIFDIRSKFAFIADLAPIIENYGTIDLFKFLIPMCRHFDELCSLLNIIRKSNNAKQAVDSTLPIFIKKVLTFTKDPMINSGNLSTVFNIVSPIYGQNVPSEFVEKFILSFALQGNYTMMAHMIDTYKIKLSHKYQLQIIRALKNSERNHALKNTGAVGYNKEFKKYFIEKYLNCTEREALRP
What is the function of this protein?
Required for translation of the mitochondrial OLI1 transcript encoding subunit 9 of mitochondrial ATP synthase.
What are the official names of this protein?
ATPase expression protein 1, mitochondrial, Nuclear control of ATPase messenger RNA expression protein 1.
What is the protein family that this protein belongs to?
Belongs to the AEP1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CPEB2_HUMAN
Sequence: MPPPSPDSENGFYPGLPSSMNPAFFPSFSPVSPHGCTGLSVPTSGGGGGGFGGPFSATAVPPPPPPAMNIPQQQPPPPAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQRNSYNHHQPLLKQSPWSNHQSSGWGTGSMSWGAMHGRDHRRTGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPSLTPKSWIEDNVFRTDNNSNTLLPLQVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYDSLNMHSLENSLIDIMRAEHDPLKGRLSYPHPGTDNLLMLNGRSSLFPIDDGLLDDGHSDQVGVLNSPTCYSAHQNGERIERFSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGARCGGKFAPFFCANVTCLQYYCEFCWANIHSRAGREFHKPLVKEGADRPRQIHFRWN
What is the function of this protein?
May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids.  Binds to poly(U) RNA oligomers (By similarity).  Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195).
What are the official names of this protein?
Cytoplasmic polyadenylation element-binding protein 2, CPE-BP2, CPE-binding protein 2, hCPEB-2.
What is the protein family that this protein belongs to?
Belongs to the RRM CPEB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_I96A3
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGRWTKNTETGAPQLNPIDGPLPKDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLIANESGRLIDFLKDVMESMDRDEVEITTHFQRKRRVRDNVTKKMVTQRTIGKKKHKLDKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISFTITGDNTKWNENQNPRMFLAMITYITKNQPEWFRNILSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNDSTKKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNYAGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGVNESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWDQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVMMPAHGPAKNMEYDAVATTHSWVPKRNRSILNTSQRGILEDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKTCSTIEDLRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: HYCA_ECOLI
Sequence: MTIWEISEKADYIAQRHRRLQDQWHIYCNSLVQGITLSKARLHHAMSCAPDKELCFVLFEHFRIYVTLADGFNSHTIEYYVETKDGEDKQRIAQAQLSIDGMIDGKVNIRDREQVLEHYLEKIAGVYDSLYTAIENNVPVNLSQLVKGQSPAA
What is the function of this protein?
Regulatory protein for the formate hydrogenlyase system.  Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence (PubMed:1625581).  Also down-regulates expression of the hyf operon (PubMed:12426353).
What are the official names of this protein?
Formate hydrogenlyase regulatory protein HycA.