PharMolix/UniProtQA huggingface dataset:
Protein: ECCC5_MYCTO
Sequence: MKRGFARPTPEKPPVIKPENIVLSTPLSIPPPEGKPWWLIVVGVVVVGLLGGMVAMVFASGSHVFGGIGSIFPLFMMVGIMMMMFRGMGGGQQQMSRPKLDAMRAQFMLMLDMLRETAQESADSMDANYRWFHPAPNTLAAAVGSPRMWERKPDGKDLNFGVVRVGVGMTRPEVTWGEPQNMPTDIELEPVTGKALQEFGRYQSVVYNLPKMVSLLVEPWYALVGEREQVLGLMRAIICQLAFSHGPDHVQMIVVSSDLDQWDWVKWLPHFGDSRRHDAAGNARMVYTSVREFAAEQAELFAGRGSFTPRHASSSAQTPTPHTVIIADVDDPQWEYVISAEGVDGVTFFDLTGSSMWTDIPERKLQFDKTGVIEALPRDRDTWMVIDDKAWFFALTDQVSIAEAEEFAQKLAQWRLAEAYEEIGQRVAHIGARDILSYYGIDDPGNIDFDSLWASRTDTMGRSRLRAPFGNRSDNGELLFLDMKSLDEGGDGPHGVMSGTTGSGKSTLVRTVIESLMLSHPPEELQFVLADLKGGSAVKPFAGVPHVSRIITDLEEDQALMERFLDALWGEIARRKAICDSAGVDDAKEYNSVRARMRARGQDMAPLPMLVVVIDEFYEWFRIMPTAVDVLDSIGRQGRAYWIHLMMASQTIESRAEKLMENMGYRLVLKARTAGAAQAAGVPNAVNLPAQAGLGYFRKSLEDIIRFQAEFLWRDYFQPGVSIDGEEAPALVHSIDYIRPQLFTNSFTPLEVSVGGPDIEPVVAQPNGEVLESDDIEGGEDEDEEGVRTPKVGTVIIDQLRKIKFEPYRLWQPPLTQPVAIDDLVNRFLGRPWHKEYGSACNLVFPIGIIDRPYKHDQPPWTVDTSGPGANVLILGAGGSGKTTALQTLICSAALTHTPQQVQFYCLAYSSTALTTVSRIPHVGEVAGPTDPYGVRRTVAELLALVRERKRSFLECGIASMEMFRRRKFGGEAGPVPDDGFGDVYLVIDNYRALAEENEVLIEQVNVIINQGPSFGVHVVVTADRESELRPPVRSGFGSRIELRLAAVEDAKLVRSRFAKDVPVKPGRGMVAVNYVRLDSDPQAGLHTLVARPALGSTPDNVFECDSVVAAVSRLTSAQAPPVRRLPARFGVEQVRELASRDTRQGVGAGGIAWAISELDLAPVYLNFAENSHLMVTGRRECGRTTTLATIMSEIGRLYAPGASSAPPPAPGRPSAQVWLVDPRRQLLTALGSDYVERFAYNLDGVVAMMGELAAALAGREPPPGLSAEELLSRSWWSGPEIFLIVDDIQQLPPGFDSPLHKAVPFVNRAADVGLHVIVTRTFGGWSSAGSDPMLRALHQANAPLLVMDADPDEGFIRGKMKGGPLPRGRGLLMAEDTGVFVQVAATEVRR
What is the function of this protein?
Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.
What are the official names of this protein?
ESX-5 secretion system protein EccC5, ESX conserved component C5, Type VII secretion system protein EccC5, T7SS protein EccC5.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYY_ORITI
Sequence: MHFINEFINRGYFYQSTDLTRLTQISNSSQIVAYIGFDCTAQSLHVGNLMQIMILRLLQQCGHKSIVVIGGATTKIGDPSEKDKLRRIITNDEIQQNISGIKRSLKKFIKFDETKNDVLLLNNQEWLDSINYINFLRDYGRAFSVNKMLTMNSVKSRLERHTPLSFLEFNYMLLQAYDFYYLNKYYNCNLQIGGSDQWGNITMGVDLVKKLSNNEVFGLTTPLITNSSGEKMGKTADGAVWLNEDMCSPYNYFQYWRNIEDNDVIRFAKLYGEFSEVELSKLTELFFNNVNEAKKQIAYKITLLCHGRDEANKALNTAIQMFEHKKADENLPTFTIKDCNNLKVGIPITELLVTIGLAKTKSEGKRLIQGNGIRINNIKVNNINLVVQLHDFIDQVITVSLGKKCHILVKIAK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOGA1_COCIM
Sequence: MVPRVPQPGIWCPAVTFFDSKTDTLDLASQERYYAYLARSGLTGLVILGTNAEAFLLTREERAQLIATARKAVGPDFPIMAGVGAHSTRQVLEHINDASVAGANYVLVLPPAYFGKATTPPVIKSFFDDVSCQSPLPVVIYNFPGVCNGIDLDSDMITTIARKNPNVVGVKLTCASVGKITRLAATLPPAAFSVFGGQSDFLIGGLSVGSAGCIAAFANVFPKTVSKIYELYKAGKVDQAMELHRKAALAESPCKSGIATTKYAAAIFSAKAAGIEDAEEKLRPRKPYDPPSEAAKQEVRKVMAEVAAIEAGLS
What is the function of this protein?
May catalyze the final step in the metabolic pathway of hydroxyproline.
What are the official names of this protein?
Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial, Dihydrodipicolinate synthase-like, DHDPS-like protein.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
Protein: RS5_PSELT
Sequence: MDEILEEELEKKESEEFEERIVEIRRTAKVTKGGKTLSFRVLAVVGNRKGKVGVGVGKAREVPEAIRKAIAAARASVVEIPLYKTTIPHEVFGRQDASKVLLRPAAPGTGIIAGSTVRAVVELAGVQNVLTKCLGSTASVNLALATLNGLKDLVSPEKAAKLRDITPAQVLYGARKEA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: SSRP_HELPY
Sequence: MKLIASNKKAYFDYEILETLEAGLALLGSEVKALRQTRVNLKDNFVKIIKGEAFLFGVHISYLDTIHAYYKPNERRERKLLLHKKQLLKWQIEASKERLSIVGLKLYFNQRNRAKIQIALVKGKRLHDKRQSLKEKALNKEILADLKHHFKG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes (Probable).  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation (PubMed:19043582).
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: TRMD_DICT6
Sequence: MLRIDIITIFPEMFRGPFDVSILKKAQDRGFVEIKVHNLRDFTEDKHRTVDDYPYGGGSGMVMKPEPIFKAVKTLRKEKSEVILLSPSGDLFNQKIAEELSKKDHLILICGRYEGVDERVKKIITREISIGDYVLTGGEIPAMVLVDAIVRLIPGVLGDPNSLKEESFQWGILEYPQYTHPREFEGMEVPEILLSGNHKEIRRWRRKEALRKTFLKRPDLLEKVELTQEDLELLEEIKKELREEV
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFR1_MOUSE
Sequence: MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAADEEENADNNMKASVRKPKRFNGRLCFAAIALVIFFLIGFMSGYLGYCKRVEQKEECVKLAETEETDKSETMETEDVPTSSRLYWADLKTLLSEKLNSIEFADTIKQLSQNTYTPREAGSQKDESLAYYIENQFHEFKFSKVWRDEHYVKIQVKSSIGQNMVTIVQSNGNLDPVESPEGYVAFSKPTEVSGKLVHANFGTKKDFEELSYSVNGSLVIVRAGEITFAEKVANAQSFNAIGVLIYMDKNKFPVVEADLALFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPNIPVQTISRAAAEKLFGKMEGSCPARWNIDSSCKLELSQNQNVKLIVKNVLKERRILNIFGVIKGYEEPDRYVVVGAQRDALGAGVAAKSSVGTGLLLKLAQVFSDMISKDGFRPSRSIIFASWTAGDFGAVGATEWLEGYLSSLHLKAFTYINLDKVVLGTSNFKVSASPLLYTLMGKIMQDVKHPVDGKSLYRDSNWISKVEKLSFDNAAYPFLAYSGIPAVSFCFCEDADYPYLGTRLDTYEALTQKVPQLNQMVRTAAEVAGQLIIKLTHDVELNLDYEMYNSKLLSFMKDLNQFKTDIRDMGLSLQWLYSARGDYFRATSRLTTDFHNAEKTNRFVMREINDRIMKVEYHFLSPYVSPRESPFRHIFWGSGSHTLSALVENLKLRQKNITAFNETLFRNQLALATWTIQGVANALSGDIWNIDNEF
What is the function of this protein?
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity).  Endosomal acidification leads to iron release.  The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.  Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).  Upon stimulation, positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).  Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity).  When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity).  When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
What are the official names of this protein?
Transferrin receptor protein 1, TR, TfR, TfR1, Trfr.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Melanosome.
Protein: ARLY_SYMTH
Sequence: MTKLWGGRFTKPADKTAEGFTSSLAFDRRLYKQDIRGSIAHVRMLGRQGIIPAADAARIEQGLREIEAEIEAGQFPFRQEYEDIHLNIEKRLIEKIGPAGGRLHTARSRNDQVVTDVHLWVKDEIAAVQRLVSDLQGTLLDRAREQMGAVMPGYTHLQRAQPVLLSHHLMAYFWMLERDYGRFADALRRADVSPLGAGALAGTTFPIDREFTAAELGFAGVYPNSMDAVSDRDFIVEFVAAAAICQMHLSRLAEELVMWSSTEFGFVEMDDAYATGSSIMPQKKNPDVAELVRGKTGRIYGDLMALLTVLKGLPLAYHTDLQEDKERLFDAVDTLKACLTVMTGMLATLKFNRERMAQAVRRDFSNATDMADYLVKKGMPFREAHEVVGKAVLYCVERGKFLADLTLEEFKAFSALFEADIYQAIAPETCVSQRTSLGGTAPAEVERQLALAAEILSRRMG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTH_ECO24
Sequence: MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALAGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQVERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_METVS
Sequence: MEEERIYTIPLRDVTNKSPTTKRAPRAIRAIRAFLMKHMKSDVVKLDNSINEKVWERSLNKIPAKVRVKAVKEGDVVKATLIE
What are the official names of this protein?
50S ribosomal protein L31e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL31 family.
Protein: TRPD_BRADU
Sequence: MDDLKSIIGKVATGASLSRDEAASAFDAMMSGEATPSQMGGLLMALRVRGETVDEITGAVAAMRSKMLTVTAPPDAVDIVGTGGDGSGSVNVSTCASFIVSGAGVPVAKHGNRALSSRSGAADVLASLGVRIDLRPEQVGRCVRECGIGFMFAPAHHPAMKNVGPTRVELATRTIFNLLGPLSNPAGVKRQMVGVFSRQWVQPLAQVLKNLGSESAWVVHGSDGLDEITLTGPTFVSSLHNGEIRNFEVTPEEAGLPRCEPGALKGGDADANAIALQSVLNGKPSAYRDVALMNAAAALVVAGRAKDLKEGVALGAKSLDSGAANARLKHLIAVSNG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: HSP5_OCTVU
Sequence: YRRRRRRGRRGRRRRGRRRRSRGRRRAHGG
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P5, Po5.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: KR212_HUMAN
Sequence: MCCNYYRNCCGGCGYGSGWSSGCGYGCGYGCGYGSGCRYGSGYGTGCGYGCGYGSGCGYGCGYSSSCCGYRPLCYRRCYSSCY
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 21-2.
Protein: MMP3_MOUSE
Sequence: MKGLPVLLWLCVVVCSSYPLHDSARDDDAGMELLQKYLENYYGLAKDVKQFIKKKDSSLIVKKIQEMQKFLGLEMTGKLDSNTMELMHKPRCGVPDVGGFSTFPGSPKWRKSHITYRIVNYTPDLPRQSVDSAIEKALKVWEEVTPLTFSRISEGEADIMISFAVGEHGDFVPFDGPGTVLAHAYAPGPGINGDAHFDDDERWTEDVTGTNLFLVAAHELGHSLGLYHSAKAEALMYPVYKSSTDLSRFHLSQDDVDGIQSLYGTPTASPDVLVVPTKSNSLEPETSPMCSSTLFFDAVSTLRGEVLFFKDRHFWRKSLRTPEPEFYLISSFWPSLPSNMDAAYEVTNRDTVFIFKGNQFWAIRGHEELAGYPKSIHTLGLPATVKKIDAAISNKEKRKTYFFVEDKYWRFDEKKQSMEPGFPRKIAEDFPGVDSRVDAVFEAFGFLYFFSGSSQLEFDPNAKKVTHILKSNSWFNC
What is the function of this protein?
Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans.  Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9.  Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway.  Acts also intracellularly.  For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage (PubMed:17116747).  In addition, plays a role in immune response and possesses antiviral activity against various viruses (PubMed:35940311).  Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311).
What are the official names of this protein?
Stromelysin-1, SL-1, EMS-2, Matrix metalloproteinase-3, MMP-3, Transin-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: URE1_BURMA
Sequence: MTLRLSRRAYAEMYGPTTGDRIRLADTELLIEVERDHTLYGEEVKFGGGKVIRDGMGQSQLPAADVADTVITNAVILDHWGIVKADIAIKHGRIAAIGKAGNPDIQPGVTIAIGAATEIIAGEGLIVTAGGIDTHIHFISPQQIDEALASGVTTMIGGGTGPATGTNATTCTPGPWHMERMLQAADGWPINLGFLGKGNASRPQPLVEQIEAGAIGLKLHEDWGTTPAAIDNCLTVADDTDTQVAIHTDTLNEAGFVEATVAAFKGRTIHTYHTEGAGGGHAPDILKVCGEANVLPSSTNPTRPYTINTLDEHLDMLMVCHHLDPSIAEDLAFAESRIRRETIAAEDILHDLGALSMLSSDSQAMGRVGEVIIRTWQTAHKMKVQRGALAGDGARNDNFRAKRYVAKYTINPALTHGIAHEVGSIEPGKWADLVLWEPAFFGVKPAMIVKGGMIAVAQMGDPNASIPTPQPVHYREMFATRGGALARTSLTFVSQLALDAGIGARYGLAKRLVPVRGCRTVTKRDMIHNAWQPAIRVDPETYDVVADGALLTCEPAAVLPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YKO4_CAEEL
Sequence: MLRFFQMTWTTALYFLVFLSFGNSMPQKSKPFWLSADINSIEWQEGCLTTVLCSHPRFQLLKDLLPISERASISWPVTEQFLEHTVAPFVSYWPSGRIEDVSLSAQVVGVDTTYGFPRTCDQTPAVRIFPVDLYELAPESAENKTIHLKAKCFEATITVTKHVERCPWCPDPQEILISNEIPQQINLQQSALESGIHSFVGIFYKSSTSESLQVGICLLAALAFFASLAFIIMLSVYLKSKKSSRRNVSVNVQPRLIPYNSRCDDYDTRYDMPWDQQRPLTYWMSKSTVTSPNSLRSEAYQTYRIPPPPNFAPPV
What are the official names of this protein?
Uncharacterized protein C05B5.4.
Protein: TTLL9_RAT
Sequence: MSRQKSQTSKGHGASKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKQLEREAGKTEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIMDWRKGTAGKKVTSVETQATRANVNPSGSHDTRSSDDQKDDIPVENYVAQRYVENPYLIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDHYVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPKAVETLFSDMDNIFIKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGKEKRVGGFDLMWNDGPVSREEGPCDLSGMGNFVTNTHLGCINDRKEQLRQLFRSLQVQKKASS
What is the function of this protein?
Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins.  Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity.  Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern.
What are the official names of this protein?
Probable tubulin polyglutamylase TTLL9, Tubulin--tyrosine ligase-like protein 9.
What is the protein family that this protein belongs to?
Belongs to the tubulin--tyrosine ligase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: SAHH_BRUAB
Sequence: MTASQDFVVKDISLADWGRKELDIAETEMPGLMAAREEFGKSQPLKGARISGSLHMTIQTAVLIETLKVLGAEVRWASCNIFSTQDHAAAAIAATGTPVFAVKGETLEEYWTYTDQIFQWPDGEPSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEEEEVLFAQIKKRMAATPGFFTKQRAAIKGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRGTDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAAMDGFEVVTLDDAASTADIVVTTTGNKDVITIDHMRKMKDMCIVGNIGHFDNEIQVAALRNLKWTNVKPQVDLIEFPDGKRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLGQIELFTRTDAYKNEVYVLPKHLDEKVARLHLDKLGAKLTVLSEEQAAYIGVTPQGPFKSEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHOSP_RABVH
Sequence: MSKIFVNPSAIRAGLADLEMAEETVDLINRNIEDNQAHLQGEPIEVDNLPEDMRQFHLDDEKLSNLGEMVRVGEGKYREDFQMNEGEDPNLLFQSYLDNVGVQIVRQMRSGERFLKIWSQTVEEIISYVSVNFPNPPGRSSEDKSTQTTGRELKKETTSILSQRESQPSKAGMVAQVASGPPSLEWSATNGEDDLSVEAEIAHQIAESFSKKYKFPSRSSGIFLYNFEQLEMNLDDIVKEAKNVPGVTRLAHDGSKIPLRCVLGWVALANSKKFQLLVEADKLSKIMQDDLDRYTSC
What is the function of this protein?
Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication.  Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA.  Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus.  Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity).  Inhibits interferon induction pathways by interacting with host TBK1 and preventing the formation of dynamic cytoplasmic condensates that have liquid properties and that are essential for interferon production (By similarity).
What are the official names of this protein?
Phosphoprotein, Protein P, Protein M1.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus protein P family.
What are the subcellular locations of this protein?
[Phosphoprotein]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Isoform P2]: Host cytoplasm. SUBCELLULAR LOCATION: [Isoform P3]: Host nucleus. SUBCELLULAR LOCATION: [Isoform P4]: Host nucleus. SUBCELLULAR LOCATION: [Isoform P5]: Host nucleus.
Protein: CB21_PEA
Sequence: TTKKVASSSSPWHGPDGVKYLGPFSGESPSYLTGEFPGDYGWDTAGLSADPETFAKNRELEVIHSRWAMLGALGCVFPELLSRNGVKFGEAVWFKAGSQIFSEGGLDYLGNPSLVHAQSILAIWATQVILMGAVEGYRIAGGPLGEVVDPLYPGGSFDPLGLAEVPEAFAELKVKELKNGRLAMFSMFGFFVPAIVTGKGPLENLADHLADPVNNNAWSYATNFVPGK
What is the function of this protein?
May channel protons produced in the catalytic Mn center of water oxidation into the thylakoid lumen.
What are the official names of this protein?
Chlorophyll a-b binding protein AB96, LHCII type I CAB-AB96, LHCP, Major 15.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: RS18_MYCCT
Sequence: MQVKKIKKRKKVNFFQKNNIKYIDYKDVELLKKFISPNGQILPRRITGTSLKDQRQLALAIKRARQMALLPYVIE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RL24_STRP3
Sequence: MFVKKGDKVRVIAGKDKGTEAVVLKALPKVNKVIVEGVGMIKKHQKPNTENPQGAIVEKEAPIHVSNVQVLDKNGVAGRVGYKVVDGKKVRYSKKSGEVLD
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RS5_VIBA3
Sequence: MAKEQQQANDLQEKLIAVNRVSKTVKGGRIMSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRNMVTVALNEGTLHHPVKGRHSGSKVYMQPAAEGTGVIAGGAMRAVLEVAGVHNVLSKAYGSTNPINVVRATIGALVDVKSPEMVAAKRGLTVESISE
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: STMX_STOCA
Sequence: MNFYKYLVVLVVLVLCLSATQTEARGFRKHFNKLVKKVKHTISETAHVAKDTAVIAGSGAAVVAATG
What is the function of this protein?
May play an important role in protecting the stored blood in the anterior midgut from microorganisms prior to digestion.  Adopts an amphipathic alpha-helical structure only in the presence of an organic solvent that mimics a phospholipid membrane.
What are the official names of this protein?
Stomoxyn.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA_SPHAL
Sequence: MFAGLAKSLFGSSNDRYVNSIRKIVERINAFEPAMQALDDAGLQGQTATFRARLAAGETLDDILPEAFATVREAAVRTLGMRHFDVQMIGGVVLHRGEIAEMATGEGKTLMATLPCYLNALSGKGVHVVTVNDYLARRDAEWMGAVYGFLGLTTGVIVPNLNETQRREAYNSDITYATNNELGFDYLRDNMKFDRAQMVHRPFNFGIVDEVDSILIDEARTPLIISGPTDDKSELYIRVNEVVLQLTEEDYEKDEKSKSINLTEEGTEHVERLLEAAGLLQGSNLYDIENTQVVHHVNQALKAIQMFRIDTDYIVKDGKVVIIDEFTGRMMEGRRWSDGLHQAVEAKEGVQIEPENQTLASITFQNYFRMYPKLSGMTGTAATEAAEFFDIYKMNVVTIPTNRPIARIDEEDEFYKNINDKFGAIARTIREAQERGQPVLVGTVSIEKSELLSSFLEKEGVAHSVLNARFHESEARIVAQAGRSGAVTIATNMAGRGTDIKLGGNEEFRIEDELKDMPAGPERDAAEARIREEVAAEREAVKAAGGLFVLATERHESRRIDNQLRGRSGRQGDPGLSKFYLCLDDDLLRIFGPDTLFAKMMNKNLEDGEAIGSKWLSKAIETAQKKVEARNYDIRKQVVEYDNVMNDQRKVIYEQRGEIIDSETVDDVMAAMRAETVNAIVADACPPGSYPEQWNVEGMKERVANILNLHPPIDEWMQEDAVDPEMFEERLQRMADATAAEKAALVDAETWKGIEKSILLQTLDHHWKEHLATLDALRQVVFLRAYAQKQPINEYKQEAFALFERMLSNIREDVTRTVARIDFQFQEPEPMPLPELPDFLTTHIDPFTGEDNSADVDAGSLGVIADTLPPMQVPKHDIARGENPYAAMEISRNAPCPCGSGRKYKHCHGAI
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: COBD_BRUA4
Sequence: MEIKLIILSLALLLDRFVGDPPQLWQKVPHPVVLFGKAISWGEKRWNNRNLSASVLRRNGMWLTIGLVMACVVLGLVLELSLPFAGTAGAVAEILIVTVLLAQKSLADHVQAVALALREEGIEGGRRAVSMIVGRNPEHLDEGGVSRAAIESLAENASDGIVAPAFWFLVGGLPGLFAYKLINTADSMIGHLNDRYRDFGRFAAKLDDVANYIPARLTGLLASLATAITKDRLSGKEAFSVMRRDARLHRSPNAGWPESAFAGGLGLALAGPRQYGAEKVEGPMLNASGKRDANADDIDAALHLFWSTMSLMTGLVIAASLIGLLVG
What is the function of this protein?
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
What are the official names of this protein?
Cobalamin biosynthesis protein CobD.
What is the protein family that this protein belongs to?
Belongs to the CobD/CbiB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.