PharMolix/UniProtQA huggingface dataset:
Protein: U520_MOUSE
Sequence: MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDMNKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRREIDLLLGQTDDTRYHVLVNLGKKITDYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEPEKERIVGKMEADPELSKFLYQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGGHNYTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD
What is the function of this protein?
Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.  Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).  Involved in spliceosome assembly, activation and disassembly.  Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome.
What are the official names of this protein?
U5 small nuclear ribonucleoprotein 200 kDa helicase, BRR2 homolog, U5 snRNP-specific 200 kDa protein, U5-200KD.
What is the protein family that this protein belongs to?
Belongs to the helicase family. SKI2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPF_ACIAD
Sequence: MVVQIRIGQGMDVHAFEEGDHVTLAGIKIPHTHGLKAHSDGDVVLHALSDALLGALALGDIGQHFPDTDVQFKGADSRVLLKHVYQLILDRGYALNNADITVACERPKLAKYNLEMRQSIADVLDVDVTQISVKATTTEKLGFTGRQEGILATATVLVSYQAK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RUTA_KLEP7
Sequence: MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSKIQIYATAATLTLPPAIVARMASTIDSISGGRFGVNLVTGWQKPEYDQMGMWPGDDYFASRYDYLTEYVQVLRDLWGTGRSDFKGDYFTMNDCRVSPRPSQPMKVICAGQSDAGMAFSAQHADYNFCFGKGVNTPTAFAPTAARMMQAAEKTGRDVGSYVLFMVIADETDEAARAKWEHYKAGADEEALAWLTEQSQKDTRSGSDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGTDGVLLTFDDFLAGIDAFGERIQPLMRCRNHIASVTREVA
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
Protein: FOGG_ASPRC
Sequence: MAVTFDISPEKEAGVLRLFHSQLFVTPPPLTRRDVDLSGKTAIVTGANGGLGLETAHQLLDLGCKVILAVRRVERGEAARQKLLEGRDAQATEIEVWPLDLSSYESVVGFAERAKTLSRLDIAILNAGLYKVNQTMTASTGYEESIHVNYLANALLITLLAPIFKNKKTGNTPGRIVLVSSDLAAWAKFKERKSNPILPTFKQKMTPKWDYLERYGTSKVLGQFFVTELAKRVSPDAVLVTTTNCGLCHGSELSREGQGHLIGYVFNVVSRLFGRSCSVGARVFVHAAANPVLGASVHGQYVEDAKLKPMSPLIYKPGDLQLGSKLWEETMDELSFAGAREIIDSLTK
What is the function of this protein?
Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of flavoglaucin and congeners (including aspergin, dihydroauroglaucin and auroglaucin), prenylated salicylaldehyde derivatives carrying a saturated or an unsaturated C-7 side chain (PubMed:32134669).  The PKS fogA releases the carboxylic acid (8E,10E,12E)-3,5,7-trihydroxytetradeca-8,10,12-trienoic acid as its product, as well as derivatives with one and two double bonds (PubMed:32134669).  FogA is indeed able to reduce the initial triketide, thus being at least partially responsible for the differently saturated heptyl side chains of flavoglaucin congeners (PubMed:32134669).  The oxidoreductases fogB, fogC and fogD modify the nascent polyketide in fogA-bound form and, together, fogA, fogB, fogC and fogD are necessary for the formation of the aromatic core and the cyclized PKS products are released as salicyl alcohols (PubMed:32134669).  In particular, fogB is responsible for oxidation of a hydroxyl group or reduction of remaining double bond(s) at the C-7 residue whereas fogD is probably involved in the reductive release of the modified PKS products (PubMed:32134669).  The cytochrome P450 monooxygenase fogE is then responsible for the hydroxylation at C-3 of the benzene ring (PubMed:32134669).  The fogE products are substrates of the prenyltransferase fogH and the prenylated benzyl alcohols are subsequently oxidized by the fogF to produce the final aryl aldehydes flavoglaucin and congeners (PubMed:32134669).  The short-chain dehydrogenase fogG does not seem to be involved in the biosynthesis of the prenylated salicylaldehyde derivatives (PubMed:32134669).
What are the official names of this protein?
Short-chain dehydrogenase fogG, Flavoglaucin biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: OAS1B_MOUSE
Sequence: MEQDLRSIPASKLDKFIENHLPDTSFCADLREVIDALCALLKDRSFRGPVRRMRASKGVKGKGTTLKGRSDADLVVFLNNLTSFEDQLNQQGVLIKEIKKQLCEVQHERRCGVKFEVHSLRSPNSRALSFKLSAPDLLKEVKFDVLPAYDLLDHLNILKKPNQQFYANLISGRTPPGKEGKLSICFMGLRKYFLNCRPTKLKRLIRLVTHWYQLCKEKLGDPLPPQYALELLTVYAWEYGSRVTKFNTAQGFRTVLELVTKYKQLQIYWTVYYDFRHQEVSEYLHQQLKKDRPVILDPADPTRNIAGLNPKDWRRLAGEAAAWLQYPCFKYRDGSSVCSWEVPTEVGVPMKYLLCRIFWLLFWSLFHFIFGKTSSG
What is the function of this protein?
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA (PubMed:12396720, PubMed:27663720).  The full-length protein displays antiviral activity against flaviviruses such as west Nile virus (WNV) via an alternative antiviral pathway independent of RNase L (PubMed:12080145, PubMed:16371364, PubMed:17904183, PubMed:27663720).  The truncated form of the protein lacks antiviral activity (PubMed:12080145, PubMed:16371364, PubMed:17904183).
What are the official names of this protein?
Inactive 2'-5'-oligoadenylate synthase 1B, (2-5')oligo(A) synthase 1B, 2-5A synthase 1B, 2'-5'-oligoadenylate synthase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the 2-5A synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Protein: MNMA_SINMW
Sequence: MNSLDFDRKPEDTRVVVAMSGGVDSSVVAGLLKREGYDVLGITLQLYDHGAAVHRAGSCCAGQDIDDARRVCETIGIPHYVLDYEARFRETVINPFAESYIAGETPIPCVACNQTVKFADLLATAKELGADALATGHYIRSRPSPMPRYPGQRALYRPADADRDQSYFLFATTQEQIDYLRFPLGGLPKSETRALAEEMGLVVAKKADSQDICFVPQGKYSDIVSKLKPNAALAGEIVHLDGRVLGAHEGILHYTIGQRRGIGVATGEPLYVVYLDARSRRVVVGPKEALETRRVYLRDVNWLGDEELEAAARSGFECFAKVRSTRRPAPAVLSCDAEGLYVELVEGEAGVAPGQACALYSGIGEDARVYGGGFIRRSEREPAAEAALKALLQAPAAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYP0_RAT
Sequence: MAPGAPSSSPSPILAALLFSSLVLSPTLAIVVYTDREVYGAVGSQVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPSWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGILGVVLLLLLLFYLIRYCWLRRQAALQRRLSAMEKGKFHKSSKDSSKRGRQTPVLYAMLDHSRSTKAASEKKSKGLGESRKDKK
What is the function of this protein?
Is an adhesion molecule necessary for normal myelination in the peripheral nervous system.  It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
What are the official names of this protein?
Myelin protein P0, Myelin peripheral protein, MPP, Myelin protein zero.
What is the protein family that this protein belongs to?
Belongs to the myelin P0 protein family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ILL3_ARATH
Sequence: MANSSIVALLLLFVIASSVNGGDQEYPNQYLTEALGDKEWLVSVRRQIHENPELLFELHKTSALIRRELDELGVSYSYPVAKTGIVAQIGSGYPPVVALRADMDALPLQELVEWDHKSKIDGKMHACGHDSHTTMLLGAAKLLSKRKRMLNGTVRLLFQPAEEGGAGAFHMIKEGALGDSEAIFGMHVHTGLPTGELATISGPALASTSIFSVRMSGKSPASSETYSCVDPVLAASSTILALQLIISREVDPLLSHVLSVTFMKSGGSEFDVIPAYVEFGGTLRSLTTNGINWLIKRLKEVVEGQAEVQRCKADIDMHEDDHPMYPATVNDHKLHEFTEKVLKLLLGPEKVKPANKVMAGEDFAFYQQKIPGYYIGIGIRNEEIGSVRSVHSPYFFLDENVLPIGSATFAALAEMYLQEHQNQTKSGD
What is the function of this protein?
Hydrolyzes certain amino acid conjugates of the plant growth regulator indole-3-acetic acid (IAA).
What are the official names of this protein?
IAA-amino acid hydrolase ILR1-like 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20 family.
Protein: UPP_KLEP3
Sequence: MKIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLATEKVTIEGWNGPVEVEQIKGKKITVVPILRAGLGMMEGVLEHVPSARISVVGIYRNEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKNAGCTSIKVLVLVAAPEGIAALEKAHPDVELYTASVDKGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: ARGJ_ZYGRC
Sequence: MKFSSVLKQSAKYAAHVPKSGVFPRGFQVGSIASGVKKNGNLDLGVLVNTNKSYESSAASVFTTNKFKAAPVILSQRVLEEKNGKGINAIVVNSGCANSVTGEVGLQDATQMAKLIDEKLGATSPSTLIMSTGVIGQRLQMDKISKGVSQLFANNSFGSDFNSWLNIAKSICTTDTFPKLITSNFTLKNGTQYTLTGMAKGAGMICPNMATLLGFIVTDLPIESKALSKMLKFATDRSFNCISVDGDMSTNDTINMIANGAVKTDEITEDSPEFLQVRDQVTQFAQKLAQLVVRDGEGATKFVTVKVQNSSTFADAKIIAESISNSMLVKTALYGKDANWGRILCAIGYAKLDNLDSLQTDKLNVSFVATDNSEPRELKLLVNGVPQLNIDEERASQILALPDLEVLVDLGTGNEEAQFWTCDLSHEYVTINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CSRA_DESVM
Sequence: MLILTRRPGESLYLGDNIRITILGMQGKQVKIGLDVPGDMVVYREEVYRRVMEENRMALETSNADLLAATQIWHDRTKE
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDA_CLOBJ
Sequence: MSSTKWTDEQRQAIFTKNCNLLVAAGAGAGKTAVLVQRIIEKILDKEEPIDIDKLLVVTFTNAAAAEMRERIGDAISKGLDEDPESKVLRKQLTLLNKSNIMTIHSFCLQVIKNNFHTIEIDPNFRICDETEGILMKQEAIDELFDELYEIENEDFINLVESYASRKDIRLQEVVLELHRFAKSAPFPYTWLLNMAEGFNVGENFNFEETLWADMIMEDMKVLLHGFKNMLQQSIDVILNSEGIDYYYEPFKMDLSFINSLLEKSSFKEFRGEIIAYDFPKLPLKRNKDADKEAKERVKKLRDRVKKRIIELRITLNSYENEFTKKEFIFLYPSMKALSNLVILFDKKYEAKKRERDLIDFNDIEHLCLSILTDKNSEGHIIPSDIALNYRKKFAEVLIDEYQDSNLVQEVIMSMVSRVKGYWSFYNGQLIFNEEEINLEEPQIGLDIPNRFMVGDVKQSIYRFRQAKPEIFLDKYNEYSEEEGTKNRKVKLFKNFRSREEVINGVNYLFKQIMSKTIGELDYTEEEALKVGASYGEEVKGEPIELCLMDKKYEISEEVLKEYNVDEEEALDNIQLEGRLVAKKIQKLVGNNLEGGLKVFDRKLGEYRNLQYRDIVILMRATSNWAPVFVEELAKEGIPVFADTNSGYFDTAEIKTMISLLQIIDNPLQDIPLLSVLRSPIASFTDDELIDIRMVNKNITFYECMEIIYRLYKNEKLDSYYSFYIEDENKINKIIKDMNEKLKNKICSFIEKLKLWREKSIHIDIDEFIWFLYVETGYYGYAGALQAGEQRQANLRILFQRAKQYAKTSYKGLFNFINFINKLKFSSGDMGSAKILGENENVVRIMSIHKSKGLEFPVVILSGTGKNFNMMDLNKNILFHRDLGYGPDYVDTERRIAYPSLVKNIIKNKIRLETLSEEMRILYVALTRAREKLIITGLINNMDKTVEDWLNLSEDKNKVPEYAVMSGKTYLDWIGPALIKHKDAVSFREELKMTSELSNIVDDKSKWKIELWNKRELLKEKVEEDEVEISEKIKETLMNLEESDYKEEIYKRLSFKYKYDNASSIPTKLSVSDVKKQFILDEKENTEELFKKLELRKPMFMEEKKKISPSERGTIIHLFMQHLDLKKAENEEDIKEQINRLIEREFITYEQSKVISSYKILKFCRGELGKRILNSNNVNKEMPFSIEIPALEIYKELDKEIYKDEKLIIQGVIDCYFEEEDGLVLLDYKTDYVNDIEEIKNRYEIQIKYYEEALNRITGKNVKDKYLYLFSVDNYIKID
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: CYSN_BUCAI
Sequence: MNINMKDNFKKWLDLQQKKTLLKFLTCGSVDDGKSTLIGRLLHDTKQIYDDQLFFLKSDSKRHGTQGNEIDLALVVDGLQSEREQGITIDVAYRYFSTNKRKFIIADTPGHEQYTRNMATGASTCDLSILLVDARKGLSEQTYRHSFISTLLGIKYLIVAINKMDLVNYKQEIFENIKKDFLIFSKKLANDLNIIFIPMSALLGENIVFKTKLMPWYQGVTLLSFLETIKIKNSISSEELRFPVQYINRPNSDFRGYSGILLSGRMHVGQTIKILPENINSRVSRIVTFDKELKKAEIGESITVVLKDEIDINRGDFFVNIDSILQPSQEAIIDIVWMTDNILLAGESYNVKLSGKKIRVYIKEILFKLDVNTLKKVKSHSLVLNSIGRVKIYFSKPVIFDNYSENRMTGNMIFIDLLTNITVGAGMIVNSLDKKGKIPSNKQKDFESDFYDLIIRHFPHWNIPKILMKKVYK
What is the function of this protein?
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 1, ATP-sulfurylase large subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Protein: TCPZ_MOUSE
Sequence: MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIRKKDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGIALNSFDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLVKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVALAEALIKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLSTGEPMVAAEMGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.  The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.  The TRiC complex plays a role in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit zeta, TCP-1-zeta, CCT-zeta-1.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFC25_SCHPO
Sequence: MRRPNLDRLRLKSRQGFETSVSKPSTPSYSTYSLSPTFSDKSVLSPSTMSDSYALSSTYTAGSSYQNGESDYFGSLPTPSSDKSSTSPFPYLKGSFDDRFSSTHSLTRQPSPRSPLTPLKGNTRASPEIRYVSDFTPPSSPFEDMQASVHSLPLSGCSIGPVRTNHSSSLSNSSNSLLQTESSLRPNSSFVNSPFFPLPSSDDLFLNDRVINLFLFYEKFSYLFTHLLSAIKSRDALSIPSLVLSLQEELFNLCQQTGTFYLLQHNLLQNFEFENPIKLHFDKIIPYFSRLTVLTFSNRAFIFPDHTFPRLQQSAEDFLYHLQFFFTLCANNSLYLSRFCYYPSFVPNTPFGGKWTNNGLSAVSSAYRTRLLEPCLPELDKCVWFLLKNCDEFIENFSDFADEEYVFEICSTITSHSEQIFNKLESWDMSIYFDKDLSECEQATNFAVQSYFVTKQRCYDLLTDLVCSSQDLMMEHSNDFSTMPTMIASIAVAFQTLFENVCDFLKVRAALVDEMQELATKEFENKFSNANTAKDDEPARQTNKGTTRISRSSDFTAVSEMSKDTLTLGRNSLQSILMLDNLLTNKVVQSDNNVKGGTLPALVHYLVQNVHLNKDFRHSFLLTYKTFTTPQELFTLLVILFHELPPPGLDATAYSSWEKGDNFVTKKNVCTVMNLWVQKYFFEDLKARNTLYLISEMRTFLRDHVVPSFHIGSVILSEIDNLWTEEPPDSLTQRLLSSPMATFISLNVYAYTPEEFASQMTLLEFDYLKQIPSREWIFRSWVSRDSRSAVRNYINFSNCFTYWIINCILEKKNTKARTAVISFFIQTAYKCLSLQNFSTLMSIVSALNSAPIYRLHAAYKLVKAEDIICLSGLREIVETKKNFSTYRALLRKAELPCVPFLGVILSDLTFIDEGNPDVLDSSPHLLSFNKRHRLADVVADVCRFQSSSYEMQSNTDLQSYILHRCRFVNQDLSYLFDKSLSLEPRSS
What is the function of this protein?
Has a role in chromosome segregation and cell morphology upstream of the ras1-scd1 pathway.  Promotes the exchange of ras1-bound GDP by GTP leading to its activation.
What are the official names of this protein?
Ras guanine nucleotide exchange factor efc25, Exchange factor cdc25p-like protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_CHLTE
Sequence: MPTIQQLIRHGRSMKASKTASPALEKCPQKRGVCTRVYTTTPKKPNSALRKVARVRLSNKIEVTAYIPGEGHNLQEHSIVLIRGGRVKDLPGVRYHIVRGSLDTSGVADRKQSRSKYGAKVPKAGAAPAKKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RL16_ALIB4
Sequence: MLMPKRTKFRKMMKGRNRGMAHRGNSLAYGDFGIKAVEHGRIDSRQIEASRIAMTRKVKRQAKVWIMVFPDKPLTAKPLETRMGKGKGSVDKWVMNIKPGRICFEMAGVGEELAREALALAMHKLPFKTKIVTRDSENELY
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RBL_VITVI
Sequence: MSPQTETKASVGFKAGVKDYKLTYYTPEYETKPTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEESQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIFKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDFVEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIRAASKWSPELAAACEVWKEIKFEFPAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NFUA_ACIBT
Sequence: MSTENTNTAVAEEIPNLLITPSAQEYLHELLAKQNTPGIGVRIFVEHPGTPRAECCMAYSAPEEVVPTDYKQDYPDFPAYIDAPSIPYLLDAVIDYNKDRFGGQLTFRAPNSKVPRVGPDASIEERITYVLQAEINPGLAGHGGNCSLVEVQDDPEHGLTAVLKFGGGCQGCSAIDVTLKQGVETTLKEHIPELQRVVDQTDHTQAEGAYFK
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: EFP_ECODH
Sequence: MATYYSNDFRAGLKIMLDGEPYAVEASEFVKPGKGQAFARVKLRRLLTGTRVEKTFKSTDSAEGADVVDMNLTYLYNDGEFWHFMNNETFEQLSADAKAIGDNAKWLLDQAECIVTLWNGQPISVTPPNFVELEIVDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQIGEVIKVDTRSGEYVSRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_PSEA6
Sequence: MNIIEGNIRATGKKFALVVSRFNSFVVESLVEGALDTLERHGEVNSQDITLVRVPGAYELPIAAKKLAEKGTFDGIIALGAVIRGGTPHFEFVAGECNKGLAQVSLEFGIPVSFGVITTDSIEQAIERSGTKAGNKGAEAALGALEMVNVMANIEGAE
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RSF1_YEAS7
Sequence: MKDLNPEMGKFATTKGPPQDNRGMVDIATLPNFPANRSGTPREEMYLAPNKMETPRILNMNMVPDYLQKENFSPDFSSATVSAKSSPVNVTHDESLPLGTIESNSTKDSKYAVQRQQQQVVDFIENNMQLLSSETLNFRSDIMKTLELPIPKRRDIKGNHLSKLLFAKSPLTINTYCQFYDRRTKRICNQEMIWKDKNSREKHGSRKYQRHLSKVHDVQLTPNNFTEFFDHNSPLFQECYDYQSRLMRDLLVEPDAKFKEKKKKKKGDVNGNHPETGSSLINHQVQQQNVRELQSKIAMNDLIEILIDLNIPFSVLDYQPMRNWLIKYSIISTDTLPDEVYFKTDPGVNELEHNSSNLNNSNSGTPHNHNQNQHTN
What is the function of this protein?
Mitochondrial and nuclear transcriptional activator required for respiratory growth.
What are the official names of this protein?
Respiration factor 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion.