PharMolix/UniProtQA huggingface dataset:
Protein: OR5DI_HUMAN
Sequence: MLLTDRNTSGTTFTLLGFSDYPELQVPLFLVFLAIYNVTVLGNIGLIVIIKINPKLHTPMYFFLSQLSFVDFCYSSIIAPKMLVNLVVKDRTISFLGCVVQFFFFCTFVVTESFLLAVMAYDRFVAICNPLLYTVNMSQKLCVLLVVGSYAWGVSCSLELTCSALKLCFHGFNTINHFFCEFSSLLSLSCSDTYINQWLLFFLATFNEISTLLIVLTSYAFIVVTILKMRSVSGRRKAFSTCASHLTAITIFHGTILFLYCVPNSKNSRHTVKVASVFYTVVIPMLNPLIYSLRNKDVKDTVTEILDTKVFSY
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 5D18, Olfactory receptor OR11-143, Olfactory receptor OR11-152.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOC_PARP8
Sequence: MKALLDLFKQVQQEEVFDAIKIGLASPDKIRSWSFGEVKKPETINYRTFKPERDGLFCAKIFGPIKDYECLCGKYKRLKHRGVICEKCGVEVTLAKVRRERMGHIELASPVAHIWFLKSLPSRLGMVLDMTLRDIERVLYFEAYVVIDPGMTPLKARQIMTEEDYYNKVEEYGDEFRAEMGAEGVRELLRAINIDEQVETLRSELKNTGSEAKIKKYAKRLKVLEAFQRSGIKPEWMILEVLPVLPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELKAPEIIVRNEKRMLQEAVDSLLDNGRRGKAMTGANKRPLKSLADMIKGKGGRFRQNLLGKRVDYSGRSVIVVGPTLKLHQCGLPKLMALELFKPFIFNKLEVMGVATTIKAAKKEVENQTPVVWDILEEVIREHPVMLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQMEARTLMLASNNVLFPANGDPSIVPSQDIVLGLYYATREAINGKGEGMTFTGVSEVLRAYENKEVELASRVNVRITEMVHNEDKSEGAPAFVPKISLYATTVGRSILSEILPPGLPFSVLNKPLKKKEISRLINTAFRKCGLRETVIFADQLMQSGFRLATRAGISICVDDMLVPPQKETIVGDAAKKVKEYDRQYMSGLVTAQERYNNVVDIWSATSEAVGKAMMEQLSTEPVTDRDGNETRQESFNSIYMMADSGARGSAVQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVTQDLVVVEDDCGTSQGVAMKALVEGGEVVEALRDRILGRVAVADVVNPETQETLYESGTLLDESAVEEIERLGIDEVRVRTPLTCETRYGLCASCYGRDLGRGSLVNVGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRAAVASSVEAKSNGTVRFTATMRYVTNAKGEQIVISRSGEALITDDHGRERERHKVPYGATLLQLDGAQIKAGTQLATWDPLTRPIITEWGGTVKFENVEEGVTVAKQIDDVTGLSTLVVIDAKRRGSQSSKSVRPQVKLLDANGEEVKIPNSEHSVQIGFQVGALITVKDGQQVQVGEVLARIPTEAQKTRDITGGLPRVAELFEARSPKDAGILAEVTGTTSFGKDTKGKQRLVITDLEGNQHEFLIAKEKQVLVHDGQVVNKGEMIVDGPADPHDILRLQGIEALSRYIVDEVQDVYRLQGVKINDKHIEVIVRQMLRRVQITDNGDTRFIPGEQVERSDMLDENDRMNAEDKRPATYENILLGITKASLSTDSFISAASFQETTRVLTEAAIMGKRDDLRGLKENVIVGRLIPAGTGLAFHKARKTKEMADRERFDQIAAEEAFEFGTPETPAAEQTPHTNE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RUTC_ECOK1
Sequence: MPKSVIIPAGSSAPLAPFVPGTLADGVVYVSGTLAFDQHNNVLFADDPKAQTRHVLETIRKVIETAGGTMADVTFNSIFITDWKNYAAINEIYAEFFPGDKPARFCIQCGLVKPDALVEIATIAHIAK
What is the function of this protein?
Involved in pyrimidine catabolism.  Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously.  RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.
What are the official names of this protein?
3-aminoacrylate deaminase RutC, 3-AA deaminase.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: PSRP_POLSJ
Sequence: MSQRTVFFISDGTGITAETFGNAILAQFEFKPRHVRLPFIDSVDKAHQAIRQINHAAEVEGKRPIVFTTLVNMEILAVIKTHCNGMLLDMFGMFVAPLESELGIKSNHRVGRFSDASKSKEYDDRIEAINFSLAHDDGQSNKDLAGSDVILVGVSRSGKTPTSLYLAMQYGLKASNYPLIPEDFERRQLPPALVPHRKKIFGLTIAPERLSQIRNERRPHSTYASLANCRHEIHEAEAMMRREGIRWLSTTTKSIEEISTTILQEIRPERLEY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: TRMA_IDILO
Sequence: MTYKRIDTSEYPQQLAQKADRVREMFRPFHLNEVEVFESPASHYRMRAEFRVWHEGDDLYYIMFNPETREKIRMNEFIPGSLLINELMKELISLLKPNDVLRRKLFQVDFLTTTTGEAIISLLYHRPLDDQWEQEAIQLREALTSIAKVEVIGRARKQKRVLYKESVTEEVKVDGKSYLSLQTENSFTQPNAIINQQMISWAKRHAGNNSHDLLELYCGNGNFTLPLAENFNRVLATEISKSSVAAARENAELNNIKNVTVVRMSAEEFSAALSGELESKRAADAEIHSFDCQTVLVDPPRAGLDKDTLKLVSQYQRIIYISCNPETLTENIHDLSSSHKVTAAAMFDQFPYTDHIETGVVLERKS
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: HLDD_CUPNH
Sequence: MTIIVTGAAGFIGSNLVKGLNDRGETNVIAVDNLTRADKFHNLVDCEISDYLDKQDFLARFARGEFGKVRAVFHEGACSDTMETDGRYMMENNYRYTLSLMESCLEQGTQFLYASSAATYGASQVFREDREFERPLNVYGYSKFLFDQIVRRRLPSALSQIVGFRYFNVYGPRETHKGRMASVAFHNFNQFRADGTVKLFGEYGGYAPGMQSRDFISVEDVVKVNLHFFDHPDKSGIFNLGTGRAQPFNDIAATVVNTLREAEGKPRLSLDELVQEGLLEYVKFPDALRGKYQCFTQSDVSKLRSAGYSEPFLSVEEGVARYCRWLIERAG
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: IL12B_BUBCA
Sequence: MHPQQLVVSWFSLVLLASPIVAIWELEKNVYIVELDWYPDAPGETVVLTCDTPEEDGITWTSDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEALSRSLLLLHKKEDGIWSTDILKDQKEPKAKSFLKCEAKDYSGHFTCWWLTAISTDLKFSVKSSRGSSDPRGVTCGAASLSAEKVSVDHREYNKYTVECQEGSTCPAAEESLLIEVVVEAVHKLKYENYTSSFFIRDIIKPDPPKNLQLRPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKNKREKKLFMDQTSAKVTCHKDANVRVQARDRYYSSFWSEWASVSCS
What is the function of this protein?
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
What are the official names of this protein?
Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40.
What is the protein family that this protein belongs to?
Belongs to the IL-12B family.
What are the subcellular locations of this protein?
Secreted.
Protein: MAS5_SCHPO
Sequence: MVKETKLYEVLNVDVTASQAELKKAYRKLALKYHPDKNPNAGDKFKEISRAYEILADEEKRATYDRFGEEGLQGGGADGGMSADDLFASFFGGGMFGGGMPRGPRKGKDLVHTIKVTLEDLYRGKTTKLALQKKVICPKCSGRGGKEGSVKSCASCNGSGVKFITRAMGPMIQRMQMTCPDCNGAGETIRDEDRCKECDGAKVISQRKILTVHVEKGMHNGQKIVFKEEGEQAPGIIPGDVIFVIDQKEHPRFKRSGDHLFYEAHVDLLTALAGGQIVVEHLDDRWLTIPIIPGECIRPNELKVLPGQGMLSQRHHQPGNLYIRFHVDFPEPNFATPEQLALLEKALPPRKIESAPKNAHTEECVLATVDPTEKVRIDNNVDPTTATSMDEDEDEEGGHPGVQCAQQ
What is the function of this protein?
Probably involved in mitochondrial protein import (By similarity).  Plays a role in microtubule cytoskeleton organization.
What are the official names of this protein?
Mitochondrial protein import protein mas5.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PA_I51A0
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKTTPRPIRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPYVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDDCKDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: SCPA_BACSU
Sequence: MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLYVHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLIEYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKVLKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFLAVLELMKNQLVLIEQEHNFSDIYITGSESIHGA
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: GCST_BACC2
Sequence: MITLQRTPLFDVYAKYGGKTIDFGGWELPVQFSSIKEEHEAVRTAAGLFDVSHMGEVEVKGVDSLAFLQRVVTNDVSTLKVGGAQYTAMCYENGGTVDDLLIYKRGEEDYLLVINASNIEKDYEWLASHVIGDATVVNVSSEVAQLAIQGPKAEGILQKVVSEDLKEIKFFKFKNNILVDGIPALVSRTGYTGEDGFEIYCKSEDAAKLWEKLLEVGAEEGLKACGLGARDTLRFEATLPLYGQELSKDITPIEAGIGFAVKTNKEADFFGKATLKEQKENGAPRKLVGIEVIERGIPRTHYPVFIGEEKIGEVTSGTQSPTLKKSIGLALIDVKYAAVDTEVEIEIRNKRVKAVVVPTPFYKRSK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: NORW_AERHH
Sequence: MSTTTQSDAGISREIVVIGSGFAAQQLVKSLRKLDAEQPIRLITADSGDEYNKPDLSHVVSRGCAAAAMTRQSGSDFAEQQRIALLPHCPVLGIDPVRRLVLTEQGEFPYGQLVLATGASAVRPELPGSEHLVTLNSQQEYAAVEGAIQQARRILVLGAGLIGCELAMDMASDGREVTLLDLADSPLSALLPATLTQPLQQALRSQGVSLQFGTGLARIDGQPGDGWRVTLTDGRTSEQDLVIAAIGLRPNLALARGAGLAVERGILVGDRLQTSDPHIFALGDCVQWQGQLLPFLQPIVLGANALARTLLGTPTPLALPPMLVKVKTPRYPLQLAGRTQGEDLAWQCRWNSHGMVAEARDQAGELCGFVVGGDQMSAAFPLLRQLPR
What is the function of this protein?
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase.  Reduces the rubredoxin moiety of NO reductase.
What are the official names of this protein?
Nitric oxide reductase FlRd-NAD(+) reductase, Flavorubredoxin reductase, FlRd-reductase, FlavoRb reductase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EI2BG_YEAST
Sequence: MSIQAFVFCGKGSNLAPFTQPDFPFQTQNKDSTAATSGDKLNELVNSALDSTVINEFMQHSTRLPKALLPIGNRPMIEYVLDWCDQADFKEISVVAPVDEIELIESGLTSFLSLRKQQFELIYKALSNSNHSHHLQDPKKINFIPSKANSTGESLQKELLPRINGDFVILPCDFVTDIPPQVLVDQFRNRDDNNLAMTIYYKNSLDSSIDKKQQQKQKQQQFFTVYSENEDSERQPILLDVYSQRDVTKTKYLQIRSHLLWNYPNLTVSTKLLNSFIYFCSFELCQLLKLGPQSMSRQASFKDPFTGNQQQQNPPTTDDDEDRNHDDDDDYKPSATSIQPTYFKKKNDLILDPINCNKSLSKVFRDLSRRSWQHSKPREPIGIFILPNETLFIRANNLNAYMDANRFVLKIKSQTMFTKNIQIQSAAIGADAIVDPKCQISAHSNVKMSVLGTQANIGSRCRVAGSLLFPGVHLGDEVILENCIIGPMAKIGSKCKLSNCYIEGHYVVEPKNNFKGETLANVYLDEDEEDELIYDDSVIAGESEIAEETDSDDRSDEDSDDSEYTDEYEYEDDGLFER
What is the function of this protein?
Acts as essential component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2.  It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA.  It may promote either repression or activation of GCN4 expression depending on amino acid availability.  GCD1 stabilizes the interaction between eIF-2 and GCD6 and stimulates the catalytic activity in vitro.
What are the official names of this protein?
Translation initiation factor eIF-2B subunit gamma, GCD complex subunit GCD1, Guanine nucleotide exchange factor subunit GCD1, eIF-2B GDP-GTP exchange factor subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B gamma/epsilon subunits family.
Protein: COAD_STAA8
Sequence: MEHTIAVIPGSFDPITYGHLDIIERSTDRFDEIHVCVLKNSKKEGTFSLEERMDLIEQSVKHLPNVKVHQFSGLLVDYCEQVGAKTIIRGLRAVSDFEYELRLTSMNKKLNNEIETLYMMSSTNYSFISSSIVKEVAAYRADISEFVPPYVEKALKKKFK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PB2_I18A0
Sequence: MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIMEMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWNRNGPTTSAVHYPKIYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMIGILPDMTPSTEMSMRGVRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEVNGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: MEND_ECOSE
Sequence: MSVSAFNRRWAAVILEALTRHGVRHICIAPGSRSTPLTLAAAENSTFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPTHSISLPRPTRDIPARWLVSTIDHALGTLHAGGVHINCPFAEPLYGEMDDTGLSWQQRLGDWWQDDKPWLREAPRLESEKQRDWFFWRQKRGVVVAGRMSAEEGKKVALWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKATSELQQAQIVVQLGSSLTGKRLLQWQASCEPEEYWIVDDIEGRLDPAHHRGRRLIANIADWLELHPAEKRQPWCVEIPRLAEQAMQAVIARRDAFGEAQLAHRICDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASGKPTLAIVGDLSALYDLNALALLRQVSAPLVLIVVNNNGGQIFSLLPTPQSERERFYLMPQNVHFEHAAAMFELKYHRPQNWQELETAFADAWRTPTTTVIEMVVNDTDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: CO3_RABIT
Sequence: MNKTVAVRTLDPENLGQGGVQKEEIPSADISDQVPGTESETKILLQGTPVAQMTEDAIDGERLKHLIVTGSGCGEQNMIAMTHTVIAVHYLDHTEQWDKFSLEKRQEALELIKKGYTQQLAFKQPNSAYAAFLNRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLIMEKQKPDGVFQEDAPVIHQEMIGGQRNSVEKERALTAFVLIALQEAREICEEQVNSLAASINKSRDFLAANYMNLQRPYSVAIAAYAWAQQDKLRGAFLNKFLSKAKEKNRWEEPGQRLYNVEASSYALLALLLLRDFDSVPPVVRWLNEQRYYGGGYGSTQATFMGFQALAQYQTDVPDHKDLNMVVSIQLPSRSSPVKHRIVWDSASLLRSEETKENQGFSLTAQGKGQGTLSVVTTYFAKVKGKVTCKKFDLRVNIKTAPETVKKPQDAKSTMILGHCTRYLGDEDATMSILDISMMTGFVPDTDDLNLLSTGVDRYISKYELNKAFSNKNTLIIYLDKISHSREECLAFKVHQYFNVGLIQPGAVKVYSYYNLEETCTQFYHPEKEDGMLSKLCHKEMCRCAEENCFMQQLDEKITLNDRLDKACEPGLDYVYKTKLVQVERADDFDEYLMVVENTIKSGSDEVQAGQPAPFISHIKCRDALKLKDGKHYLMWGLSSDPVGEKPNTSYIIGKDTWVEFWPEKEECQDEENQKHCEDLGAFAESMVVFGCPN
What is the function of this protein?
C3 plays a central role in the activation of the complement system.  Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways.  After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
What are the official names of this protein?
Complement C3 alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: LIAS_NEMVE
Sequence: MNTVTENVFPPREPKPKWLRVKLPTGKNYTELRGLVDKYKLNTICASGSCPNMGECWGEGTATFMILGNICTRSCGFCGVKTGRPETVDWDEPEKVARSIKLMKIKHAVITSVDRDDLKDMGSIIWAETVKAIRRMNPNTTLETLIPDFQGNTRNLDRIIEVAPEVVSHNMETVKRLTREVRIQAKYEKSLEVLRYLKAQGIKRTKSGIMLGLGEKEEEVIQVLHDLRDANVDIVTIGQYLQPSKKHLPVKEYISPEQFEKYEKIGKELGFRHVESGALVRSSYHAEKHIH
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HCAB_ECOSE
Sequence: MSDLHNESIFITGGGSGLGLALVERFIEEGAQVATLELSAAKVASLRQRFGEHILAVEGNVTCYADYQRAVDQILTRSGKLDCFIGNAGIWDHNASLVNTPAETLETGFHELFNVNVLGYLLGAKACAPALIASEGSMIFTLSNAAWYPGGGGPLYTASKHAATGLIRQLAYELAPKVRVNGVGPCGMASDLRGPQALGQSETSIMQSLTPEKIAAILPLQFFPQPADFTGPYVMLASRRNNRALSGVMINADAGLAIRGIRHVAAGLDL
What is the function of this protein?
Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.
What are the official names of this protein?
3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase, 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase, 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase, CI-dihydrodiol dehydrogenase, Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase, Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase, PP-dihydrodiol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: COX2_LOCMI
Sequence: MATWSNLSLQDGASPLMEQLSFFHDHTMIDLLLITMIVGYSLSYMLLTKYTNRNMLHGHLIETIWTALPAITLIFIALPSLRLLYLLDDSSDAMITIKTIGRQWYWSYEYSDFINVEFDTYMTPENELNTDEFRLLEVDNRTTLPMNTEVRVLTSASDVLHSWAVPALVLKIDATPGRLNQGMFMINRPGLFFGQCSEICGANHSFMPIVIESTSIKLFIKWLSNMM
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MLS2_YEAST
Sequence: MVKISLDNTALYADIDTTPQFEPSKTTVADILTKDALEFIVLLHRTFNSTRKQLLANRSNLQSKLDSGEYRFDFLPETEQIRNDPTWQGAIPAPGLINRSSEITGPPLRNMLVNALNAEVTTYMTDFEDSSSPTWENMIYGQVNLYDAIRNQIDFKTPRKEYRLKDDISRLPTLIVRPRGWHMVEKHLYIDDEPISASIFDFGLYFYHNAKELVKIGKGPYFYLPKMEHHMEVKLWNDIFCVAQDFIGMPRGTIRATVLIETLPAAFQMEEIIYQIREHSSGLNCGRWDYIFSTIKKLRNLPEHVLPNRDLVTMTSPFMDAYVKRLINTCHRRGVHAMGGMAAQIPIKDDPKANEAAMNKVRNDKIREMKNGHDGSWVAHPALAPICNEVFSNMGTANQIYFVPDVHVTSSDLLNTKIQDAQVTTEGIRVNLDIGLQYMEAWLRGSGCVPINHLMEDAATAEVSRCQLYQWVKHGVVLSDTGDKVTPELTAKILNEETAKLASASPLGEKNKFALAAKYFLPEVTGKIFSDFLTTLLYDEIIKPSAKPVDLSKL
What is the function of this protein?
Allantoin metabolism-specific malate synthase involved in the recycling the glyoxylate generated during allantoin degradation by the ureidoglycollate (UG) hydrolase reaction.
What are the official names of this protein?
Malate synthase 2, Degradation of allantoin protein 7.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family.
What are the subcellular locations of this protein?
Peroxisome matrix. Note=Imported in peroxisome via recognition by the peroxisomal targeting signal receptor PEX9.
Protein: RS14Z_METJA
Sequence: MAKKPWKKKYGYGIRPCQRCGHVGPGLIRKYGLNLCRQCFREIAHKLGFKKLD
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: NTPPB_AROAE
Sequence: MRYSKLVLASTSAYRRLLLERFQLPFETARPDVDETPLPNEMPPDTANRLAVEKARAVAVRHPDALVIGSDQVAALNGEIFGKPGTVAAAIGQLQRMRGATVIFHTAVAVVNARTGQVRCENVPTRVKFRELSDDEIVRYVDKERPLDCAGSAKSEALGITLLDSLSGDDPTALVGLPLIALSRMLRAEGLLLP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.