PharMolix/UniProtQA huggingface dataset:
Protein: EAK6_CAEEL
Sequence: MTNIREDENIFMFLCEKWILINKNHIWNRINQRINIIADFDRYQRARTISEGQRTENIHRNIYGAVPYDYNLVNLTSTQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDFMAFYNTMKEVGVPLLAVMKNNCMSSFFKKYHHTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQLRHLEKYLEAHANTVRMIDSTNTEDVDKFIKPRDWIVDFDERDRLIGKLQFRKRLKIEKDQVSEQKLVHLKSQLHLFQDTYKYESYVLQ
What is the function of this protein?
Putative phosphatase which, together with eak-4 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1.
What are the official names of this protein?
Tyrosine-protein phosphatase non-receptor type eak-6, Enhancer of akt-1 null 6.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: RS2_PROMS
Sequence: MAVVSLSEMMEAGAHFGHQTRRWNPKMSKYIYCARNGVHIIDLVKTALCMNNAYKWTRNAAKSGKRFLFVGTKKQASDVVAQEATRCGAAYVNQRWLGGMLTNWTTMKARIERLKDLERMESSGSIAMRPKKEAAVLRRELERLQKYLGGLKGMRRLPDVVVLVDQRRESNAVLEARKLDISLVSMLDTNCDPDLCEVPIPCNDDAVRSVQLILGRLADAINEGRKGSNAERKN
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: ISPD_PORG3
Sequence: MKQKRYALIVAGGHGLRMGADRPKQFLLLAGLPVLMHTLNRFAPHVDAIVLVLPTDHHAYWQELCRKYDFSVSHRVVAGGNTRFASVRNGLQVVPDGVLVAVHDGVRPLVSAETIDACFDLAELKGAVAPCRPMTESLRYYATDGNYAVDRSRYVTVQTPQTFRSEWLREAYRQPYEEYFTDDCSVYEHHFGRPVALIVGNIENIKLTTPLDLSLAKLLLTS
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: APAH_SALA4
Sequence: MATYLIGDVHGCYDELIALLQQVEFTPDTDTLWLTGDLVARGPGSLDVLRYVKSLGNSVRLVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQVDEEKKLVMAHAGITPQWDLQTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELSGLARLRFITNAFTRMRYCFPNGQLDMYSKASPENAPAPLKPWFAIPGPVSEAYSIAFGHWASLEGKGTPEGIYALDTGCCWGGELTCLRWEDKQYFVQPSNRQMDMGEGEAVNA
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: CY550_NOSS1
Sequence: MFRRLIGVVVATALLTFQLIVGSATALELDEATRTVPLNAQGDTVTLSLKQVKEGKRLFQYACAQCHVGGVTKTNQNVGLEPEALALATPNRNNIEGLVDYMKNPTTYDGVEEISEIHPSLKSADIFTAMRNLTDKDLESIAGHILLQPKILGDKWGGGKIYY
What is the function of this protein?
Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II.
What are the official names of this protein?
Cytochrome c-550, Cytochrome c550, Low-potential cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PsbV subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with photosystem II at the lumenal side of the thylakoid membrane.
Protein: TBB5_WHEAT
Sequence: MREILHIQGGQCGNQIGSKFWEVVCDEHGIDPTGRYVGTSDLQLERVNVYYNEASCGRFVPRAVLMDLEPGTMDSVRTGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQMYRSLTVPELTQQMWDSKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIAPRGLSMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVAEYQQYQDATADEEEELYEDEDDADLQE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-5 chain, Beta-5-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: DB123_MACMU
Sequence: MKLLLLTLTVLLLLSQLTPGGTQRCWNLYGKCRHRCSKKERVYVYCLNNKMCCVKPKYQPKEKWWPF
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 123, Defensin, beta 123.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CAPSD_TTVB1
Sequence: MPPFYYRRRWYSNPWRRKRLRFRRRRLRRPIRKRFRRRRWVRRRRFFRFKRKLRKIRIDQWQPETIRKCHVKGNLCLLTCGRGNINHNYILTSESYVPTSEPGGGSWSILQMTTRVLYDEYKAARNWWTKSNSLLPLTKYIRCKLKFYRSDQTDYIVTIQRTGPFEVTLESYLSTQPSRHLMNHKAFIVPKLGRGPNKETYVKKIVRPPALFQSKWYFSQDIYNTPLFILTVSSCSLDQMYAPQDQISTNISLFSLNTNVFQINNWHKQPYTTKAASTLETYLYCYHNGHEPTQELKWKDIILLGNMTNYTDGKKYNTSGTTPLDLFKTENKPYWGNVFTNLNQDQDVIIYYGTKPKQDDNWTSTAPILPITSLYVECRYNPFKDKGTGNKVYLVPTDSGLGSFLTLPTKSELIITDLPLWLITWGWIEWLKKSRPVAHIEEEYQVVIQSKYIHPQLPCYVLIDKYFRHPPEGQHYITELSETDKLHWHPKYSMQTEQLELIAETGPAAPKINNTKQIEAHLNYDFLFKWGGSPAPMETITDPAEQEKFPSPSNQLQGLQIESPGKPKQYYLYTFDEKRSELTMPAAKRLKKDFTTPTFFTDFGTKDIPLKTQEETDQISEDEEIETSLPKEDHLKQQLQRTRQYYREGIRKLLKTKKLFPL
What is the function of this protein?
Self-assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins.  The capsid encapsulates the genomic DNA.  Capsid protein is involved in attachment and entry into the host cell (By similarity).
What are the official names of this protein?
Capsid protein.
What is the protein family that this protein belongs to?
Belongs to the anelloviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: NPSR1_MACMU
Sequence: MPANFTEGSFDSNGTGQMLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKRKSRMTFFVTQLAITDSFTGLVNILTDIIWRFTGDFMAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCGERRSQDSIMTFRERTERHEMQILSKPEFI
What is the function of this protein?
G-protein coupled receptor for neuropeptide S (NPS).  Promotes mobilization of intracellular Ca(2+) stores.  Inhibits cell growth in response to NPS binding.  Involved in pathogenesis of asthma and other IgE-mediated diseases.
What are the official names of this protein?
Neuropeptide S receptor, G-protein coupled receptor 154.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NDK_CAUVN
Sequence: MTERTFSIIKPDATRRNLTGAINAVIEAAGLRIVAQRRVKLTEAQAKKFYEVHAERPFYGELVGQMTAEPVVVQVLQGDNAVLKYREVMGATNPENADEGTIRKLFALSIGENSVHGSDSLENAGIEIAQFFTEDEIVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_LEPBA
Sequence: MKDSLVLKTIQEKIKNLGSLPGCYLWKNELGQVIYVGKALKLQSRVRSYLNPNQKDRKTRALFVELYDLDWIATGTEKEALLLEATLIKKYNPKFNVRLKDDKKYPFLCVSTSEDYPMVFLTRKVKDNGDRYFGPFTDVKAARDTLELIHRIFPIRKTKLKLPLPKPQRPCLNFHMGRCLGPCQGNVTKDTYSELVDEILRFLEGKKERLVADLKKAMMDASSKMEYERAGFLKQRIEKINQLREKQTVVSMDGGDEDILGISKREDEGQILILEVRGGRLEGKKSFPLTGLSFSDDEEAFTSFLRDYYLNVTVLPSVVYLPTSAKGNYDVFLEAILEKFGTSIKLKFPEMGPKKSLLRLAEKNADLSLTERILATKLRDQTVAMKELQEKLNLPTLPRTIECYDISHFQGSLPVASGVMFVEGKPYKPGYRHYKMRGYEGINDPGMIHEVIARRLSHLVNEEEPLPDLIVIDGGLTQLSRAAEAANALDLGHIPMVGLAKKREEIYFPGEKHPYSFDQHSPMMRLLRNLRDEAHRFGVTFQRLQRKKKALKSILDDIPDIGASRRKSILMYFQAKKKVTDATRQELEKVQGIGPVLAEKIFTNIQNLKKIEPK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLP2_BOVIN
Sequence: MADSERLTAPGCWAACTSFSRTRKGFLLFAEIILCLVILICFSTSTSGYSFLSVIEMIFAAIFFVVYMCDLHTKIQIINWPWSDFFRTLVAAILYLITSIVVLVERGNGSKIAAGALGLCAAGLFGYDAYITFPLRQQRHTAAPTDPADGPV
What is the function of this protein?
May play a role in cell differentiation in the intestinal epithelium.
What are the official names of this protein?
Proteolipid protein 2.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CARB_ECO57
Sequence: MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEKERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATADAIDKAEDRRRFDVAMKKIGLETARSGIAHTMEEALAVAADVGFPCIIRPSFTMGGSGGGIAYNREEFEEICARGLDLSPTKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAMGIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETGGSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIAKVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALRGLEVGATGFDPKVSLDDPEALTKIRRELKDAGAERIWYIADAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVGITGLNAEFLRQLKRKGFADARLAKLAGVREAEIRKLRDQYDLHPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSTDREKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQHAVDRLKLKQPANATVTAIEMAVEKAKEIGYPLVVRPSYVLGGRAMEIVYDEADLRRYFQTAVSVSNDAPVLLDHFLDDAVEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQKLAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSKATGVPLAKVAARVMAGKSLAEQGVTKEVIPPYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGSNSTMKKHGRALLSVREGDKERVVDLAAKLLKQGFELDATHGTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTSGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATAMALNADATEKVISVQEMHAQIK
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: RL24_FRACC
Sequence: MATLKIKKGDTVQIITGKDRGLKGKVIRAYPEQNKVLVEGANRITRHTRVQQGTRGSQSGGIITQEAPIHVSNVMIVDPSDGKPTRIGYRINDDGTKVRVSRRTGTEL
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: MSRA_XANCP
Sequence: MLGIGAFKQRMPRSGEALPGRTQALPLHNTHLINGHPLRGEFTGLAQVQFGLGCFWGAERKFWNVPGVYTTAVGYAGGKTPNATYSEVCSGQTGHTEAVLVVYDAQAVSFEQLLRTFWESHDPTQGMQQGNDVGTQYRSAIYCSTQAQYDAAIASRDAYQQQLTAAGYGDITTEILYPAPTFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: IF2_MYCLB
Sequence: MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASSTVEAPVARRLRESFGGIKPAADKGAEQVATKAQAKRLGESLDQTLDRALDKAVAGNGATTAAPVQVDHSAAVVPIVAGEGPSTAHREELAPPAGQPSEQPGVPLPGQQGTPAAPHPGHPGMPTGPHPGPAPKPGGRPPRVGNNPFSSAQSVARPIPRPPAPRPSASPSSMSPRPGGAVGGGGPRPPRTGVPRPGGGRPGAPVGGRSDAGGGNYRGGGVGALPGGGSGGFRGRPGGGGHGGGGRPGQRGGAAGAFGRPGGAPRRGRKSKRQKRQEYDSMQAPVVGGVRLPHGNGETIRLARGASLSDFAEKIDANPAALVQALFNLGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLEPFDLTYGEDQGDEDELQVRPPVVTVMGHVDHGKTRLLDTIRKANVREAEAGGITQHIGAYQVGVDLDGSERLITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEYGLVAEDFGGDTMFIDISAKVGTNIEALLEAVLLTADAALDLRANSGMEAQGVAIEAHLDRGRGPVATVLVQRGTLRIGDSVVAGDAYGRVRRMVDEHGVDIEAALPSSPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNALAARSRKRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIQVDDEVALRVIDRGVGGITETNVNLASASDAIIIGFNVRAEGKATELASREGVEIRYYLVIYQAIDDIEKALRGMLKPIYEENQLGRAEIRALFRSSKVGIIAGCIISSGVVRRNAKVRLLRDNIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKEGDVIESYELVEKQRA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL2_HYDMR
Sequence: MDQSNRYADLTLTEEKLVADGNHLLVAYRLKPAAGYGFLEVAAHVAAESSTGTNVEVSTTDDFTRGVDALVYEIDEAAFGDKGGLMKIAYPVDLFDPNLIDGHYNVSHMWSLILGNNQGMGDHEGLRMLDFLVPEKMVKRFDGPATDISDLWKVLGRPEVDGGYIAGTIIKPKLGLRPEPFAKACYDFWLGGDFIKNDEPQANQNFCPMEVVIPKVAEAMDRAQQATGQAKLFSANVTADFHEEMIKRGEYVLGEFAKYGNEKHVAFLVDGFVTGPAGVTTSRRAFPDTYLHFHRAGHGAVTSYKSPMGMDPLCYMKLARLMGASGIHTGTMGYGKMEGHNDERVLAYMLERDECQGPYFYQKWYGMKPTTPIISGGMDALRLPGFFENLGHGNVINTCGGGSFGHIDSPAAGGISLGQAYACWKTGAEPIEAPREFARAFESFPGDADKIFPGWREKLGVHK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase, RuBisCO.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type II subfamily.
Protein: HTRA1_RAT
Sequence: MQFLRTALLSLLLLLLAAPSLALPSGISRSAPAATVCPEHCDPTRCAPPPTDCEGGRVRDACGCCEVCGALEGAVCGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDAKTYTNLCQLRAASRRSEKLRQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKTVTKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVTANDVSDVIKKENTLNMVVRRGNEDIVITVVPEEIDP
What is the function of this protein?
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin.  HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production.  May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin.  Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space.  Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins.  Inhibits signaling mediated by TGF-beta family members.  This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded.  By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development.  Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity).
What are the official names of this protein?
Serine protease HTRA1, High-temperature requirement A serine peptidase 1, Serine protease 11.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell membrane. Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane.
Protein: YO2B_SCHPO
Sequence: MQFDDIITKILKVGIISILFIINMAKNAVNSHFGIRTPRSVCHVRNRENIYLYWTTFDAHKLPNGGNADMAHFSANCLHAGHTVKFVSADRLGSTTWECNIKFGILSFPNFGKDDAAQNCFAEPSMKSISADTQHISAREYISGTSKGFKTATPKLLNI
What are the official names of this protein?
Uncharacterized protein C14C8.11c.
Protein: RL28_MYCPU
Sequence: MSRRDDLTGKGPMFGNNRSHALNATRRRFNLNLQKVSVVVNGRKVNLKVSAKTAKTLRRKNLI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: FPRA_MOOTA
Sequence: MSQPVAITDGIYWVGAVDWNIRYFHGPAFSTHRGTTYNAYLIVDDKTALVDTVYEPFKEELIAKLKQIKDPVKLDYLVVNHTESDHAGAFPAIMELCPDAHVLCTQRAFDSLKAHYSHIDFNYTIVKTGTSVSLGKRSLTFIEAPMLHWPDSMFTYVPEEALLLPNDAFGQHIATSVRFDDQVDAGLIMDEAAKYYANILMPFSNLITKKLDEIQKINLAIKTIAPSHGIIWRKDPGRIIEAYARWAEGQGKAKAVIAYDTMWLSTEKMAHALMDGLVAGGCEVKLFKLSVSDRNDVIKEILDARAVLVGSPTINNDILPVVSPLLDDLVGLRPKNKVGLAFGAYGWGGGAQKILEERLKAAKIELIAEPGPTVQWVPRGEDLQRCYELGRKIAARIAD
What is the function of this protein?
Has nitric oxide reductase activity in combination with Hrb; probably involved in nitrosative stress protection.
What are the official names of this protein?
Nitric oxide reductase, FMN protein FprA, Flavoprotein A, Type A flavoprotein FprA.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.
Protein: RLMD_SHEB5
Sequence: MAQFFKAKPNSSKQLSAKLSLSVNQLDHLGAGIAQHQGKVVFIPGALPDETVTVQFTEQKKNYARAKLIKVDTPSSERVEPECPHYHTCGGCDLQHMSLSGQREHKEAALLDIMAKFAGAEGGTLSPELTGEGWHYRRRARLATLFDKNTKHLSLGFRAASSSNVVPISQCQVLAKPLSDLIVPFAKLLNQLTAKASLGHLELIAADNGHFAVLRITKALNDKDLAKLSAFAEQHQIHICLQDNEGQFQGVGAELVLPVYQLLDDKAESDAVSLSFTPGNFVQVNGQINKAMVAQAMDWLAPALDERILDLFCGMGNFSLPLAKMGADVIGVEGVAEMVTQARVNAKANNLDKLTFFHGDLSADLSLEPWMGKIDKLLLDPARAGAFESLQWLKKMKPRKVVYVSCNPASLARDSAVLLERGYRLQQLGLIDMFPQTHHIEAMALFELTK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: RNZ_STAAR
Sequence: MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIFITHMHGDHIFGLPGLLSSRSFQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIEIDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTINVEALKNIGLEPGPKYQEVKSHDTFEHNGQVYQSKDFRGESKQGPIVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKHLANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQTLIQNEDTPNFNFVKDFDSFKI
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: LIPA_YEAST
Sequence: MYRRSVGVLFVGRNTRWISSTIRCGTSATRPIRSNALNTDSDNASVRVPVGNSTEVENATSQLTGTSGKRRKGNRKRITEFKDALNLGPSFADFVSGKASKMILDPLEKARQNTEEAKKLPRWLKVPIPKGTNYHKLKGDVKELGLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRTPSKPDPMEPENTAEAIKRWGLGYVVLTTVDRDDLVDGGANHLAETVRKIKQKAPNTLVETLSGDFRGDLKMVDIMAQCGLDVYAHNLETVESLTPHVRDRRATYRQSLSVLERAKATVPSLITKTSIMLGLGETDEQITQTLKDLRNIQCDVVTFGQYMRPTKRHMKVVEYVKPEKFDYWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRNMK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SLCIA_MACLB
Sequence: MGRSISVSFGLLVVFLSLSGTGADQDCLPGWSFYEGGCYYVFDVKTWEDAEKFCQKQSNGKHLATIEWLGKANFVADLVTLNSDPRLDWIGLRVEDKRQQCSSHWTDGSAVSYENVVHNTKCFGLDQKTGYRTWVALRCELAYHFICSRVPR
What is the function of this protein?
Inhibits human breast cancer cells (MDA-MB231) migration and proliferation, as well as their adhesion to fibrinogen and fibronectin.  This inhibition may be due to the binding to receptors of the integrin family, probably alpha-v/beta-3 (ITGAV/ITGB3) (40% inhibition of cell adhesion) and alpha-5/beta-1 (ITGA5/ITGB1) (by comparison with lebectin).
What are the official names of this protein?
Snaclec lebecin subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: HDA_ECOLC
Sequence: MNTPAQLSLPLYLPDDETFASFWPGDNSSLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECIAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: THI4_SCHPO
Sequence: MAPATAVVTPQTAFKTDLPVEKTAHNTVVKSEMGALSKAYPTYSLDESFSFAPIRESTVSRAMTRRYFSDLDKYAESDIVIVGAGSAGLTAAYYIGTRRPDLKIAIIEASVAPGGGAWLGGQLFSAMVVRKPADLFLNEIGVPYEDEGDYVVVKHAALFTSTVMARTLALPNVKLFNATAVEDLIVKEGKDGKQRIAGVVTNWTLVSLNHGLQSCMDPNTINAHLVVSATGHDGPFGAFCVKRLASAQLVSNLHDMRPLDMNRAEDLIVKGTREVFPGMIVGGMELSEFDGANRMGPTFGGMMFSGIKAAQEALAIFDERKAVNEKYL
What is the function of this protein?
Involved in biosynthesis of the thiamine precursor thiazole.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate.  The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.  May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
What are the official names of this protein?
Thiamine thiazole synthase, Thiazole biosynthetic enzyme.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS21_PSEP1
Sequence: MPAVKVKENEPFDVALRRFKRSCEKAGVLAEVRSREFYEKPTAERKRKAAAAVKRHAKKVQREQRRAVRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.