PharMolix/UniProtQA huggingface dataset:
Protein: GRPE_BURP0
Sequence: MENTQENPTDQTTEETGREAQAAEPAAQAAENAAPAAEAALAEAQAKIAELQESFLRAKAETENVRRRAQDDVAKAHKFAIEGFAENLLPVLDSLEAAVGDTSGDLAKVREGVELTLRQLTSALEKGRVAALNPVGEKFDPHLHQAISMVPADQEPNTVVAVLQKGYTIADRVLRPALVTVAQPK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_METNO
Sequence: MSKRDYYEVLGVARTAGEGELKSAFRKLAMAYHPDRNPGDKEAEIKFKEVNEAYQTLSDGQKRAAYDRFGHAAFSQGAGGPGGPGFGADFGDFMSDIFDTFFGDARAGGAAGARGGRAGGRERGADLRYNLEITLEEAFTGKTETIRLPTSVTCEVCAGSGAKAGSKPRTCPTCGGYGRVRAAQGFFAIERTCPNCHGRGEIIDDPCTACGGAGRVTRERTLSVNVPAGVDDGLRIRLAGEGESGLRGGPAGDLYIFLSIKPHPFFQRDGADLFCRVPISMVTAALSGEITVPVIDGSHTTVRIPAGTQTNKQFRLKGKGMPVLRSRDVGDLYIQVFVETPQNLTKRQRELLQEFDQHGSQADNHPESAGFFSRVKEFFDGLSGSGRA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G5P_BPM13
Sequence: MIKVEIKPSQAQFTTRSGVSRQGKPYSLNEQLCYVDLGNEYPVLVKITLDEGQPAYAPGLYTVHLSSFKVGQFGSLMIDRLRLVPAK
What is the function of this protein?
Binds to DNA in a highly cooperative manner without pronounced sequence specificity.  During synthesis of the single-stranded (progeny) viral DNA, prevents the conversion into the double-stranded replicative form.  G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane.
What are the official names of this protein?
DNA-Binding protein G5P, G5P, Single-stranded DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the inovirus G5P protein family.
Protein: HDAC1_CHICK
Sequence: MALTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSAGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVISKVMETFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQPIPEDAVQEDSGDEEEEDPEKRISIRNSDKRISCDEEFSDSEDEGEGGRKNVANFKKAKRVKTEEEKEEEEKKDEKEEEKAKEEKAEPKGVKEETKST
What is the function of this protein?
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).  Histone deacetylases act via the formation of large multiprotein complexes (By similarity).  Also functions as deacetylase for non-histone proteins.  In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (By similarity).
What are the official names of this protein?
Histone deacetylase 1, HD1, Protein deacetylase HDAC1, Protein decrotonylase HDAC1.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATAD1_BOVIN
Sequence: MVHAETFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDEDEIRPVQQQDLHRAIEKMKKSKDAAFQNVLTHVCLD
What is the function of this protein?
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity).  Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity).  Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory.  Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).
What are the official names of this protein?
Outer mitochondrial transmembrane helix translocase, ATPase family AAA domain-containing protein 1, Thorase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. MSP1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. Postsynaptic cell membrane; Single-pass membrane protein.
Protein: LEPA_METSB
Sequence: MTAHPIKNIRNFSIVAHIDHGKSTLADRLIQQTGAVAARDMVEQVLDSMDIERERGITIKAQTVRLEYKAADGEAYILNLMDTPGHVDFAYEVSRSLAACEGSLLVVDASQGVEAQTLANVYHALDAGHEIVPVLNKIDLPAAEPERIKQQIEDVIGLDASHAVMISAKTGVGIDLVLEAIVTRLPPPQGDETAPLKALLVDSWYDAYLGVVVLVRVIDGVLRKGQKIKMMAADAHYEVDRIGVFRPKMQDAEQLSPGEIGFITAQIKQVADTRVGDTITDERRPCAQALPGFKPAQPVVFCGLFPVDAADFEDLRAAMGRLRLNDASFSYEMESSAALGFGFRCGFLGLLHLEIIQERLEREFNLDLIATAPSVIYKIVQRDGDTIELHNPADMPDPTKIETIEEPWIRATILTPDDYLGAVLKLCQERRGVQVDLNYVGKRAMAVYDLPLNEVVFDFYDRLKSISKGYASFDYAITDYRPGDLVKMSILVNAEPVDALSMLVHRDRADTRGRVMVEKLKELIPPHMFQIPIQAAIGGKIIARETVRALRKDVTAKCYGGDASRKRKLLDKQKAGKKKMRQFGKVEIPQEAFIAALKMDG
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MOBA_NEIMA
Sequence: MKTFALILADGQASRMGGEDKGLALLGGKALIDHVIDRVRPQVSHIAISTNRNLEEYARRSPHIFPDARQWQHFGPLSALCTAANDLQLATADWLLVVPCDMPYLPDDLVARFETVSKRTPLCNAYYVETPITMHYNIMYIRPQILQSAIPYLFSGMKTLRSWLQQQRARPVRFEFDGHFADLNTQTDLQEG
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSD_STAAM
Sequence: MAEHSFDVNEVIKDFPILDQKVNGKRLAYLDSTATSQTPMQVLNVLEDYYKRYNSNVHRGVHTLGSLATDGYENARETVRRFINAKYFEEIIFTRGTTASINLVAHSYGDANVEEGDEIVVTEMEHHANIVPWQQLAKRKNATLKFIPMTADGELNIEDIKQTINDKTKIVAIAHISNVLGTINDVKTIAEIAHQHGAIISVDGAQAAPHMKLDMQEMNADFYSFSGHKMLGPTGIGVLFGKRELLQKMEPIEFGGDMIDFVSKYDATWADLPTKFEAGTPLIAQAIGLAEAIRYLERIGFDAIHKYEQELTIYAYEQMSAIEGIEIYGPPKDRRAGVITFNLQDVHPHDVATAVDTEGVAVRAGHHCAQPLMKWLNVSSTARASFYIYNTKEDIDQLINALKQTKEFFSYEF
What is the function of this protein?
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.
What are the official names of this protein?
Probable cysteine desulfurase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
Protein: KRE29_YEAST
Sequence: MGSVNSSPNEEFETVPDSQISGFDSPLIPTSVGSYFRDDDDDEKVHPNFISDPENDSLNSDEEFSSLENSDLNLSGAKAESGDDFDPILKRTIISKRKAPSNNEDEEIVKTPRKLVNYVPLKIFNLGDSFDDTITTTVAKLQDLKKEILDSPRSNKSIVITSNTVAKSELQKSIKFSGSIPEIYLDVVTKETISDKYKDWHFISKNCHYEQLMDLEMKDTAYSFLFGSSRSQGKVPEFVHLKCPSITNLLVLFGVNQEKCNSLKINYEKKENSRYDNLCTIFPVNKMLKFLMYFYSDDDNDDVREFFLKAFICLILDRKVFNAMESDHRLCFKVLELFNEAHFINSYFEIVDKNDFFLHYRLLQIFPHLQSALLRRRFSEKQGRTETIQQNIIKEFNEFFDCKNYKNLLYFILTMYGSKFIPFGPKCQVTEYFKDCILDISNETTNDVEISILKGILNLFSKIR
What is the function of this protein?
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage.  Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
What are the official names of this protein?
DNA repair protein KRE29, Killer toxin-resistance protein 29.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: AROC_GLUDA
Sequence: MSHNSFGHLFRVTTWGESHGPAIGCVVDGCPPRLPLSEADIQPWLDRRRPGQSKFTTQRQEPDAVEILSGVFEGQTTGTPISLLIRNTDQRSRDYGDIAERYRPGHADVAYDLKYGIRDYRGGGRSSARETAMRVAAGAVARRVLGEGVRIRGALTQIGAHRVDRARWDWDAVDTNPFFCPDPAMVPVWEEYLGAVRKAGSSIGAVIEIVAEGVPAGWGAPVYGKLDSDLAMALMSINAVKGIEIGDGFAAAELTGEENADPMRMVDGRLTFGANHAGGVLGGISTGQPLVARFAVKPTSSILAPVDSVTRGGENVEVSTRGRHDPCVGIRAVPVGEAMMACVLADHFLRHRAQVGP
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: LRC14_BOVIN
Sequence: MHTLVFLSTRQVLQCQSAACQALPLLPRELFPLLFKVAFMDKKTVVLRELVHTWPFPLLSFQQLLQECAHCSRALLQERPSTESMQAVILGLTARLHTPETEPGTQPLCRKHTLRVLDMTGLLDDGVEQDPGTMSMWDCTAAVARTCIEQQQGRTAEPGQAPVPVEVRVDLRVNRASYAFLREALRSSVGSPLRLCCRDLRAEDLPMRNTVALLQLLDAGCLRRVDLRFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDSRQPSVDGEDNFRYFLAQMGRFTCLRELSMGSSLLSGRLDQLLSTLQSPLESLELAFCALLPEDLRFLARSSHAVHLKKLDLSGNDLSGSQLEPFQGLLQAAAATLLHLELTECQLADTQLLATLPVLTRCASLRYLGLYGNPLSVAGLRELLRDSVVQAELRTVVHPFPVDCYEGLPWPPPASVLLEASINEEKFARVEAELHQLLLASGRAHVLWTTDIYGRLAADYFSL
What is the function of this protein?
Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.
What are the official names of this protein?
Leucine-rich repeat-containing protein 14.
What is the protein family that this protein belongs to?
Belongs to the PRAME family. LRRC14 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU2C2_AMBTC
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFHGSFIFPECILIFGLILLLMIDSTSDQKDRPWFYFISSTSLVMSITALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKRDVRSNEATTKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALLSITVGIGFKLSPAPFHQWTPDVYEGSPTPVVAFLSVTSKVAASALATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFARIVSFGPRTGTDNIRDYAGLYTKDPFLALSSALCLLSLGGIPPLAGFFGKLHLFWCGWQAGLYFLVSIGLLTSVVSIYYYLKIIKLLMTGRNKEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPIIAIAQDTFF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL30_SALNS
Sequence: MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAVRGMVNAVSFMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RR11_AGRST
Sequence: MAKAIPKIGSRKKVRIGLRRNARFSLRKSARRITKGVIHVQASFNNTIITVTDPQGRVVFWSSAGTCGFKSSRKASPYAGQRTAVDAIRTVGLQRAEVMVKGAGSGRDAALRAIAKSGVRLSCIRDVTPMPHNGCRPPKKRRL
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y865_HERAR
Sequence: MPSFDTVSEANMVEVKNAVDQAGKEITTRFDFKGSDARVEQKERDLTVYADSEFQLNQVLDVLTNKLVKRNVDVRFLDRGKIEKIGGDKVKQVVKIKNGIETEAAKKIVRILKDSKMKVQASIQGDAVRVTGAKRDDLQDAMALLRKEVADLPLEFNNFRD
What are the official names of this protein?
UPF0234 protein HEAR0865.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: KAD_COREF
Sequence: MRLVLLGPPGAGKGTQAAILSEKLGIPHISTGDLFRANIGEGTPLGIEAKQYIDAGKLVPTDVTARMVQSRLAEADAAEGFLLDGFPRTVEQADILADLLDKAGNPLDGVINYQVSEDVVVERMLSRGRADDNEETIRTRLGVYRDETAPLISHYGDKIINIEAEGSVEDINARTLEALGK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HAUS3_MOUSE
Sequence: MSCGNEFVETLKKIGYPKADILNGEDFDWLFEDVEDESFLKWFCGNVNEQNVLSEKELEAFSDLQRSGKPILEGTALDEVLRTCKTFDLKTCKLDDKEIQILEDEVQTLQKLNNSKIQRRNKYQLMVSETSYRFLALNAKQEEATKKLKQKQGFLNSVNTKLSNELQGLTEEVNNLMIFFRNSNLSERTNPMVFLSQFPLGKYISQEEQSTAALTLYTKKQFFQGMHEVVESSNEDNFQLLDIQTPSICDNEEILRERRLEMARLQMACICVQKQIIYLKTSNLSMKSSIKWAEENLNRLTNEVIDKENLDAEISSLNSEILKLEEQITHIKDKVLPAVVKEYAQLLNMPVVKGDFELQIAKQDYYTARQELVLNELIKQKASFELVQLSYEIELRKHWDTYRQLESLVQQLSQRNTVLCQHLAVLSDIPASEQLTSRTPIDTKDHSTHRLYELLEGDNKKKELFITHEHLEEVAEKLKQDVSVIQDQLAVSTQEHFFFLSKLNNDVDMLCDALYRGGNQLLLCDQELKEHFHQVESQLNELHHLLTDILADVKTKRRILATNKLHQVER
What is the function of this protein?
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
What are the official names of this protein?
HAUS augmin-like complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the HAUS3 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Protein: FEN1_DROGR
Sequence: MGILGLSKLIADLAPLAIRESEIKNFFGRKVAIDASMCLYQFLIAVRSEGAQLAAVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGAPPDMKSGELAKRAERRDEAEKALKAATEAGDEAQIEKFNRRLVRVTKEHSREAKELLKLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSCKLLRYLTYSEARKMPVKEFSYDKVLQGLELTSKEFIDLCILMGCDYCESIRGVGPKRAIELIKSYRDIETILENIDTNKYAVPENWNYKRARELFIEPDVTDASTIDLKWTDPDEDGLVQFLCGDRQFNEERVRNGAKKLLKSKQAQTQVRLDSFFKTLPSSPNAIAAAKRKAEESKKSANSKKAKIGGGSGAGRGRRPK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: RL103_ARATH
Sequence: MGRRPARCYRQIKGKPYPKSRYCRGVPDPKIRIYDVGMKRKGVDEFPFCVHLVSWEKENVSSEALEAARIACNKYMVKSAGKDAFHLRIRVHPFHVLRINKMLSCAGADRLQTGMRGAFGKALGTCARVAIGQVLLSVRCKDNHGVHAQEALRRAKFKFPGRQKIIVSRKWGFTKFNRAEYTKLRAMKRIVPDGVNAKFLSNHGPLANRQPGSAFISATSE
What are the official names of this protein?
60S ribosomal protein L10-3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: V18K_MLVAB
Sequence: MEPGGVGSSSCVVHQLPCTFPAQPRRQPPLLTACGWVSCSEDYIWPAWPPGFSLPGASDPAPRSAWSALPCPCRTTSSDGPSCHQGMGAPVLTVPAPLMLTNCPREPVLTVFSLEGSCRFKGHEVLKPGAQMGGHWKQELGSVVCHLLSVSSAVCPADLGQQA
What are the official names of this protein?
18 kDa protein.
Protein: ZN747_HUMAN
Sequence: MTDPSLGLTVPMAPPLAPLPPRDPNGAGSEWRKPGAVSFADVAVYFSREEWGCLRPAQRALYRDVMRETYGHLGALGVGGSKPALISWVEEKAELWDPAAQDPEVAKCPTEADPDSRNKEEERQREGTGALEKPDPVAAGSPGLKAPQAPFAGLEQLSKARRRSRPRFFAHPPVPRADQRHGCYVCGKSFAWRSTLVEHIYSHRGEKPFHCADCGKGFGHASSLSKHRAIHRGERPHRCPECGRAFMRRTALTSHLRVHTGEKPYRCPQCGRCFGLKTGMAKHQWVHRPGGEGRRGRRPGGLSVTLTPVRGDLDPPVGFQLYPEIFQECG
What are the official names of this protein?
Zinc finger protein 747.
Protein: QVR_DROWI
Sequence: MSLPAGNAVGNWLLILTAIFGFLTLIWIPQASAECQTRSIYCYECDSWTDARCKDPFNYTALPRDQPPLMTCNGCCVKMVRHQRSRYEVVRRMCTSQLQINLFMVDHVCMMESSGNGHMCFCEEDMCNSSKNLYTKNGYQHLINIMIIWLIGILLNQLSNR
What is the function of this protein?
Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation.  Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability (By similarity).
What are the official names of this protein?
Protein quiver, Protein sleepless.
What is the protein family that this protein belongs to?
Belongs to the quiver family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: MURC_WOLTR
Sequence: MRILNYTIINLVISKSLLLNMNGIKKGIIHIIGIGGIGMSAIAEILHNSNYKVQGSDAQSNNNVDRLQKLGIEIYIGHNANNIKQAQVVVYSSAIKSDNVELVAARNNNKTILHRSGILAEIMKDKYVIAVSGSSGKTTTTAMIASIFDHSNTDATVIVGGILNSYQNNSKLGKSDILLIEADESDETMLKIPANIAVITSINNDHIDHYGTFDNIKNAFSQFINSADFAILPDSVGINDSESVSIKFGFEGVYPFVIQSPFVVPVHDIGIKKKKSASCSIKASNVKANNIRQHNNSIEFDVLIDGCSIDRSHWIPASCTETTAVLPLSSTQITSLRSRIIKNVVLSNAIGMHKVSNALAAISVAIKLGINDVDIKKGLLEFKGVARRFSLVADIKDVKLIEDYAHHPSEIQATLTAARSITKGKIIGIIEPFRFARIRNFFDEFIRIFMMFDYVILVPVHPPEDKPILGCRIDDIQEALISNGFNNVKIMNDALLISNFISDSTNSGDIVLFIGAGINVARLARETVVFMSGVEI
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_HELPY
Sequence: MLAKMSFMQNVKNIQEVEVSHKRVLIRVDFNVPLDENLNITDDTRIRESLPTIQYCIDNKAKDIILVSHLGRPKGVEEKLSLKPFLKRLERLLNHEVVFSQNIVQLKQALNENAPTRIFLLENIRFLRGEEENDENLAKDLASLCDVFVNDAFGTSHRKHASTYGTAKFAPIKVSGFLLKKEIDSFYQAFNHPLRPLLLIVGGAKVSSKLTLLKNILDLIDKLIIAGAMSNTFLKALGYDVQDSSVEDALINDALELLQSAKEKKVKVYLPIDAVTTDDILNPKHIKISPVQDIEPKHKIADIGPASLKLFSEVIESAPTILWNGPLGVHEKQEFARGTTFLAHKIADTYAFSLIGGGDTIDAINRAGEKDNMSFISTGGGASLELLEGKILPCFEVLDKRH
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGO3_DANRE
Sequence: MEIGTTGAVGAAPQFSVPRRPGYGTMGKPIKLLANCFQVDIPKMDVYLYDVDIKPEKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKKSLYTAQPLPVASAGVDLDVTLPGEGGKDRIFKVTIKFVSLVSWHMLHEVLTGRSTPDPLELDKPISTNPVHAVDVVLRHLPSMRYTPVGRSFFSSPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYNSDPFVQEFQFRVRDEMAEVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEVLKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADNVEPMFRHLKNTYAGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEVIQDLASMVRELLIQFYKSTHYKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKEYQPGITYIVVQKRHHTRLFCADRAERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYYVLWDDNCFTADEFQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTLRTMYFA
What is the function of this protein?
Required for RNA-mediated gene silencing (RNAi).  Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them.  Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
What are the official names of this protein?
Protein argonaute-3, Argonaute3, Argonaute RISC catalytic component 3, Eukaryotic translation initiation factor 2C 3, eIF-2C 3, eIF2C 3.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Ago subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body.