PharMolix/UniProtQA huggingface dataset:
Protein: LEPA_LACGA
Sequence: MDIKKLQDYQKHIRNFSIVAHIDHGKSTIADRILELTDTVSERQMKNQLLDDMPLERQRGITIKLNSVEVKYHAKDGETYIFHLIDTPGHVDFSYEVSRSLAACEGALLVVDATQGVQAQTLANTYLAIDDDLEILPVINKIDLPSADPEMCKNEIEEMIGLDASDAVEVSGKTGQGIPELLEEIVKKVPAPNGDLNAPLKALIFDSKYDDYRGVVLSVRIEEGTVKPGDRIRIMNTGKEFEVTEVGVSSPHPVKKDMLIAGDVGYLTANIKSVRETRVGDTITSAENPTEKPLPGYRQIPPMVYSGMYPVDNQKYDDLKEALQKLQLNDAALEFEPETSQALGFGFRCGFLGLLHMDVVQERLEQEFGMDLIMTAPSVDYHAIMNDGSTKLIDNPADLPDAGEYKEVQEPYVKAEVMVPNDFVGPVMELCQRKRGEFVTMDYLDKYRVNVIYNMPLAEIIYDFFDELKSSTKGYASLDYEITGYRATDLVKIDMLLNKEPIDALSFIAHREEAQNRARQMTTMLKKLIPRQNFEVDIQGAIGAKIISRATIKPYRKDVTWKIHTGDPDRRAKLLEKQRRGKKRMKAVGKVEVPQDAFMAVLKMNDDDIKGK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PBL35_ARATH
Sequence: MGFDSVKVMENWQSKTSNENEKKKKKRRRKKNNNVRNSEHYEEEANGCWVKFRYIVCCASSTSDVETSLTLSTSTVGSQSAIVQSNDQPVGPVSSTTTTSNAESSLSTPIISEELNIYSHLKKFSFIDLKLATRNFRPESLLGEGGFGCVFKGWVEENGTAPVKPGTGLTVAVKTLNPDGLQGHKEWLAEINYLGNLLHPNLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSLPLPWSIRMKIALGAAKGLSFLHEEALKPVIYRDFKTSNILLDGEYNAKLSDFGLAKDAPDEGKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMLTGRRSMDKNRPNGEHNLVEWARPHLLDKRRFYRLLDPRLEGHFSVKGAQKVTQLAAQCLSRDSKIRPKMSEVVEVLKPLPHLKDMASASYYFQTMQAERLKAGSGSGSGRGFGSRNGQPVFRTLSSPHGQAGSSPYRHQIPSPKPKGATT
What is the function of this protein?
Involved in chitin-triggered immune signaling and is required for reactive oxygen species (ROS) production (PubMed:29907700).  Acts downstream of SD129 in defense signaling triggered by the pathogen-associated molecular pattern (PAMP) 3-OH-C10:0, a medium-chain 3-hydroxy fatty acid (PubMed:31922267).
What are the official names of this protein?
Serine/threonine-protein kinase PBL35, PBS1-like protein 35, Receptor-like cytoplasmic kinase PBL35.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: NDHI_DAMCA
Sequence: MFPMVTEFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RISB_CORGL
Sequence: MAKEGLPAVELPDASGLKVAVVTARWNAEICDRLHKHAVDAGRAAGATVSEYRVIGALELPVVVQELARTHDAVVALGCVVRGGTPHFDYVCDSVTEGLTRIALDTSTPIGNGVLTTNTEEQAVERSGGEGSVEDKGAEAMVAALDTALVLSQIRATEG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: BPT_PSESM
Sequence: MTELARLKFYATQPHTCSYLPEEQATTLFLDPSQPMDVQVYADLSDMGFRRSGDHLYRPHCQNCSACVPARIPVNLFVPDRQQKRILKRNADIQVSSAKPVFTQEYFDLYQRYIEQRHADGDMFPPSREQFSTFLVRDLPFSRFYEFRVDQRLLAVAVTDLLPNGLSAVYTFYEPDEERRSLGRYAILWQIGEATRLQLQAVYLGYWIKNCKKMNYKTQYRPIELLTNQRWVTLY
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNX_EXIS2
Sequence: MTIRILCDFDGTVTEHDNIIALMTEFAPPEAFEPLKKGVLDQSLSIQSGVGQMFRLLPSDRKQDYIDFLEQRAVIRPGFKTLLAFAKSNGIDFAIVSGGIDFFVQPILQELLTDEAIYCNGSDFSGETIRIEWPHTCDAACNNQCGCCKTSIARKLKQDGDIIVTIGDSVTDFELAKQADHVYARDYLITLCEQHGIAYTPFETFYDIVDHLQTTEVYA
What is the function of this protein?
Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase, HK-MTPenyl-1-P phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MtnX family.
Protein: GCP3_MOUSE
Sequence: MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQFAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLNLSEDPRKQASKVTSYASLFAQALPRDAHSTPYYYARPQTLPLNYQDRSTQAQSSGSLGSSGISSIGMCGLSGPTPVQPFLPGQSHQAPGVGDGLRQQLGPRLAWTLTGNQPSSQTPTSKGFPNALSRNLTRSRREGDPGGTLEVTEAALVRDILYVFQGIDGKNIKMSSTENCYKVEAKANLNKSLRDTAVRLAELGWLHNKIRKYADQRSLDRSFGLVGQSFCAALHQELKEYYRLLSVLHSQLQLEDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMKSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFITMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPRDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLEHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNRVQQAQDLDHIIAAHEAFLNTITSRCLLDSNSRVLLNQLRAVFDQIIELQNAQDVMYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIREFQDSIPKMCSQLRILTHFYQGVVQQFLVLLTTSSDESLQFLSFRLDFNEHYKAREPRLRVSLGSRGRRSSHT
What is the function of this protein?
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
What are the official names of this protein?
Gamma-tubulin complex component 3, GCP-3.
What is the protein family that this protein belongs to?
Belongs to the TUBGCP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: COBS_PROMM
Sequence: MRAPLWLRDLAGAWIFYSVLPAWPGLKPRFERIARFAPWIGLVLGGLQSFLWLVLIRADWPTSAVTLLVIGLGAWLSGGLHLDGLMDTADGLAAGRERCLQAMDDSCVGASGVQALLVVVLLQIASLLRLGSLAPLALLIAAFWGRCAPLWAMARFFYLREGQAGTASFHRRYRKGWQEALPACLVLLLALTVVPSLMIVGWPSQMVLMAGIGVGVLPAFLVPELLGRRLGGHSGDSYGASVVLVETITLLLLAVLLPAG
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NU2M_WICCA
Sequence: MLILSLFILIIYSSIINNIDTINLLSSSNKIGWKLQNYNIIRIGIIIILYSLYIFKDISLSYIFNNYNNNNDLNIYIFNDLYKLNIFNIYIIFLLLIVIISLLSINTTYLTKIQIKNNNNNISIGKSDNYIELNIYYISIIIFNIIGLILLLTSNNLISIFISIELQSYSLYILTGIIPKSQKSGHNSLFYYLIGGIGSIIILYGISLLYYITSNIFINNINLIYSLDIYNINNNILIGWLFIIIGLLIKIGAAPMYNWSILLYSNSNTIITSYISLIPKISILSYILLIILNLYNLNNLNNLFNNNNNNNLIYILSIIIILSLIIGSIGGLTQIKIKNILAYSGLLNIGYFLLIILSLINNNNINSILAYIIYITQYCFNHISIFILLIIAIIYNNNYNNFITNKNLIYIYELNYIKNNRYLIFCLIIIIGSFIGIPPLFGFYGKYYLLISSINSNYLFLSLLLIISSIISSIYYLYFLNITLFDNNNNKNNNNNNNNESLLIPSFNIINDIKNNTSLSLSNKLKNNQVGNYITYILSSYILIILFNFIQWKNILKGTYLISILLF
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CSTF1_PONAB
Sequence: MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHADAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRIAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD
What is the function of this protein?
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity).  May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity).
What are the official names of this protein?
Cleavage stimulation factor subunit 1, Cleavage stimulation factor 50 kDa subunit, CSTF 50 kDa subunit, CstF-50.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH60_WOLPM
Sequence: MTNVVVSGEQLQEAFREVAAIVDSTVAITAGPRGKTVGINKPYGAPEITKDGYKVMKGIKPEKPLNAAIASIFAQSCSQCNDKVGDGTTTCSILTSNMIMEASKSIAAGNDRVGIKNGIQKAKDVILKEIASMSRTISLEKIDEVAQVAIISANGDKDIGNSIADSVKKVGKEGVITVEESKGSKELEVELTTGMQFDRGYLSPYFITNNEKMIVELDNPYLLITEKKLNIIQPLLPILEAIVKSGKPLVIIAEDIEGEALSTLVINKLRGGLKVAAVKAPGFGDRRKEMLEDIATLTGAKYVIKDELGIKMEDLTLDDLGTAKNVKITKDNTTVVSENSDSDSVKARIEQIKSQIETSTSDYDKEKLRERLAKLSGGVAVLKVGGATEVEVKERRDRVEDALHATRAAIEEGIVPGGGVALLYASSVLDKLKGASDEEQIGINIIKKVLSAPIRRLVKNAGLESAVIIDYLIKQNDKELIYNVEAMNYANAFTAGVIDPAKVVRIAFETAVSVASVLITTESMIVDVPSKENASSPMGAGEMSGMGGF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y040_MALP2
Sequence: MALAIGLCLGLGIPISLIIGAVIGYYFAGKYFKKQLKENPPITESQIRAMYQQMGRKPTEKQIKQIMATFKKNNK
What are the official names of this protein?
UPF0154 protein MYPE400.
What is the protein family that this protein belongs to?
Belongs to the UPF0154 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DYR_SCHPO
Sequence: MSKPLKVLCLHGWIQSGPVFSKKMGSVQKYLSKYAELHFPTGPVVADEEADPNDEEEKKRLAALGGEQNGGKFGWFEVEDFKNTYGSWDESLECINQYMQEKGPFDGLIGFSQGAGIGAMLAQMLQPGQPPNPYVQHPPFKFVVFVGGFRAEKPEFDHFYNPKLTTPSLHIAGTSDTLVPLARSKQLVERCENAHVLLHPGQHIVPQQAVYKTGIRDFMFSAPTKEPTKHPRDLTMIVAVSSPNLGIGKKNSMPWHIKQEMAYFANVTSSTESSGQLEEGKSKIMNVVIMGRSCYDSLPKKNRPLKDRINIVITRNSNYNFGLTKKEKMPENLYAADCIDSALDLVAEKYGADSDIQVGKVFIIGGSFLYGSALYHPLTKNLLFTRIHKEYPCDSFFPFEPAESSDWVRKAHPELEKFVGIPVEEGRLKAASSNKEEVEIEFELYGKNDDVNVALEKLSIC
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: AF9_GIBZE
Sequence: MAPQNQLGKRVKLTQVRRPFIVGSTAKPFSDTNPRPAGIPDNHTHSWQVFVKGLDDTDITYWLRRVQFKLHESIPNYVRMVEGEPGKPFTVEETGWGEFDITIKLYYVNDSGEKPQTLYHYLRLHPYGRNEEEKQAMISSNGEICSWSYEEQLFNEPYEVFYNLLTQGAIPKGWKPSGGKGKGKTRAPPPFPTDNNEVWEHSAMIPAHNRPGQPFSLETEAAEIRKLAEAQGQAEDMAKKILAELKAKEEQLATLKGENQAAAAAAKS
What is the function of this protein?
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A.  The NuA4 complex is also involved in DNA repair.  Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).
What are the official names of this protein?
Protein AF-9 homolog.
What is the protein family that this protein belongs to?
Belongs to the YAF9 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS6_BURVG
Sequence: MRHYEIVFIVHPDQSEQVPAMIERYKTTITTHGGQIHRVEDWGRRQLAYMIEKLAKAHYVCMNIECDQTTLDELEHAFKFNDAVLRHLIVKMKKAETGPSPMMKEVQREEAKKAAAAQPTEAQA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: MS2B_DROME
Sequence: MNYFAVICIFSCICLWQFSDAAPFISVQSSSQSRSQKVMNGMLRTLYDYSVQDSVNDATGHLIQTHKADFNSDVMSPDEIESVRQQLNMA
What is the function of this protein?
This protein is transferred from male to female during mating and may affect egglaying and behavior after mating.
What are the official names of this protein?
Accessory gland-specific peptide 26Ab, Male accessory gland secretory protein 355B.
What are the subcellular locations of this protein?
Secreted, extracellular space. Cytoplasm.
Protein: LNT_BRUSU
Sequence: MIARLAGRIILLSGWRRALAAFLSGAFATLTQPPFDIFVAGFVSFPVLVWLIDGAIARTDAGPLRRLLPAAKVGWWFGFGYFVSGLWWIGTALLVDADQFAWALPLAVLGLPAFLALFYAFAAMIARLLWSDGLGRILALAFGFALAEWLRTFIFTGFPWNLIGYAAMPVPLLMQSVAVIGLVGMSALAVFVFAAPALLTGGHFARTGIGLAIFLALAHVGFGAWTLSRAPAIVDENGPLAVRIVQPSIAQAMKWDNAERRAIFDKLVGLTEEAPAEGKPRPDVIVWPETAIPYILESTPQALAHIGDALQEGQVLLAGAVREEKGADGGEPRYYNSIYTIDDRGRIVSTADKVHLVPFGEYLPFESFLRGLGLQEVVEMPGGFTAGTTRHALAVKDGRSFLPLICYEAIFPDELGYEGAGASAIINVTNDAWYGDTPGPYQHFRQAQVRAVEQGLPLIRAANNGLSAIVNTYGRITGSLALDAVGVVDSYLPSPRDPFWGRPPGWIQTVLILLTLLAASVGLILYSRRRFH
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SAHH_STRFR
Sequence: IPGIVKDEVKPQVHTWTFADGKKIIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELYTKPEQYPTDVYVLPKHLDEKVARLHLDALGVKLTTLRPEQAEYIGVEVEGPYKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_SULIN
Sequence: MGLNLLPIEMDDIRKRLDREPNEIEWRVIDAVWSEHCSYKSSKIFLKSFSIDSPNVIMGIKDWQDAGAVDIGDGWAIVIKVESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALMDMIRVGNLKIRKNVWLLKNIIAGIAAYGNSIGVPVVGGELSFDDTYNDNPLVDVAAIGIVRKDKIKPSIVDKAGLKLVLAGLTGIDGLGGASFASRKLSGEDEIGAVQIADPFAGKIILDVTLEIADKVEAIKDLGGGGLAVAVTEMANGLGAIVDIEKIPLRVKNMDPADVIISETQERMLYAVEEKNVEEVCKAFEEYEYPCSVIGEITSEPIIKFRYFGKDLVSLPTNALLEPPKFLWPIKNVRKNVEEKNVDLSLESTIYTVLSHPDLVSKEWVYSQFDYEVNTSTVVKPGDANGAVVSLPNGKLLAIKADGNPDLCSEDAYECGKGIVAEAYRNLATVGARGMVAVDHLQFGDPKKPEVYYTFVEAIRGIGEATRFFNIPIVGGKVSFYNENSQGKPIKPTPLIVMAGLVQGKLLKNRVEDSSYVVLLGYTRKELGGSLLSKIFKVPSQAPKVRLQEDLLSSEVVIDAINEEKITFAKDISRGGLAASLFNIIVHGYGVEISTKSILSDTDNVVENLFSESSGRFVILTNEPEWIVEKSRSKGIVASIIGKVNKKTSILTIDNTDYDLKTIVNNYFNFLEEVIGNG
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DML1_CANAL
Sequence: MSEIITLSYGSICNNTVTHLYNTQESLISYTPSSKPNHDLQVFLTRFKSTSVSYSPRALIYDLRNGLGALNKYEYHETLPVDLNFSLLSTNTTAPAGAETGAGSSLESGYNLKKSRVEKNEYQQKLDQGVTDGSSLNVNNTKYWTDYNKLIYNPKSLTTVNNFVHNENNHESGYHYNFNSLKYDSFNIGQEEFKACNNGNGGYGYDDNDNNKSIENFRYFLEKTDRLQGLQLLTNLNDAWGGFTSEMLIDLIDEFFNNTSSDKQNLWIYGIMNSTKLSEKTQSIRTKLSFIKTLIELTKQSSLIFPMNLNNSKDESWHNNYSMLTDKYNSGSNWHQSSLYATFINSIWGLNNQLKNQISMTHLQNDIVKLNPNQKIINQIKIKQEKSGNGDKQNQLFGSDLNQFNLKDIVNLKDLSNLGKSSDTSATQREINLGISKNASTNTGNDAYHNFVQNRISSSTSQNEKMMKDKEQEQNGIINNYLNPYIDNIFQVETFPVDILKSSSNAINISTEFNVNDGLKSYLKPYIKLVSNIRNQHREYLDIIEDKEELLEDLNNISQEYSYGYESDDEDYE
What is the function of this protein?
Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
What are the official names of this protein?
Protein DML1.
What is the protein family that this protein belongs to?
Belongs to the misato family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EFTU1_THET8
Sequence: MAKGEFVRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEQMHRNPKTRRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRRTVVTGVEMHRKTLQEGIAGDNVGVLLRGVSREEVERGQVLAKPGSITPHTKFEASVYVLKKEEGGRHTGFFSGYRPQFYFRTTDVTGVVQLPPGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE
What is the function of this protein?
Protects glycyl-tRNA(Gly) from hydrolysis by E. coli D-aminoacyl-tRNA deacylase (dtd) (PubMed:27224426).
What are the official names of this protein?
Elongation factor Tu-A, EF-Tu-A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQ3_RAT
Sequence: MWRGGRLSSRGVRFLETLGFACPSAVAEPPRVTSWTAFSGNQLTRNLQIKPWEFSGHRTMWLRSYRITFSCLTRLKTYRSSWKKLYSTSQTVDSKEVKTFQALAHSWWDEQGKFAPLHSMNDLRVPFIRDNLLKTSTNHDPGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVLDKRIQYRVCSLEETLNENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFITTVNKTQLSYVLGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGMVYNPFSGYWHWTENTSLNYAAHAVRARAQEHLEPAESA
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, mitochondrial, 3-demethylubiquinol 3-O-methyltransferase, Polyprenyldihydroxybenzoate methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: M2_I03A1
Sequence: MSLLTEVETPTRNEWECRCSDSSDPLVVAASIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTAGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: FADB_SALG2
Sequence: MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGQALEVLEKQHDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTLAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRLPRMLGADSALEIIAAGKDVGAEHALKIGLVDGVVKQEKLIEGAIAVLRQAITGDLDWRAKRQPKLEPLKLSKIEAAMSFTIAKGMVAQTAGKHYPAPMTAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDIETPKQAAVLGAGIMGGGIAYQSAWKGVPVIMKDINDKSLNLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDVVVEAVVENPKVKKAVLAETEQKVRPETVLASNTSTIPIGELASALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKVDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKEYRDAIDALFDASRFGQKNGLGFWRYKEDSKGKPKKEEDAAVDDLLASVSQTKRDFSDDEIIARMMIPMINEVVRCLEEGIIASPAEADMALVYGLGFPPFHGGAFRWLDTQGSAKYLDMAQQYQHLGPLYEVPEGLRNKARHNEPYYPPVEPARPVGSLKTA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.