Protein: POLG_HE71B
Sequence: MGSQVSTQRSGSHENSNSATEGSTINYTTINYYKDSYAATAGKQSLKQDPDKFANPVKDIFTEMAAPLKSPSAEACGYSDRVAQLTIGNSTITTQEAANIIVGYGEWPSYCSDNDATAVDKPTRPDVSVNRFYTLDTKLWEKSSKGWYWKFPDVLTETGVFGPNAQFHYLYRSGFCIHVQCNASKFHQGALLVAVLPEYVIGTVAGGTGTENSHPPYKQTQPGADGFELQHPYVLDAGIPISQLTVCPHQWINLRTNNCATIIVPYMNTLPFDSALNHCNFGLLVVPISPLDFDQGATPVIPITITLAPMCSEFAGLRQAVTQGFPTELKPGTNQFLTTDDGVSAPILPNFHPTPCIHIPGEVRNLLELCQVETILEVNNVPTNATSLMERLRFPVSAQAGKGELCAVFRADPGRDGPWQSTMLGQLCGYYTQWSGSLEVTFMFTGSFMATGKMLIAYTPPGGPLPKDRATAMLGTHVIWDFGLQSSVTLVIPWISNTHYRAHARDGVFDYYTTGLVSIWYQTNYVVPIGAPNTAYIIALAAAQKNFTMKLCKDTSDILETATIQGDRVADVIESSIGDSVSKALTPALPAPTGPDTQVSSHRLDTGKVPALQAAEIGASSNASDESMIETRCVLNSHSTAETTLDSFFSRAGLVGEIDLPLKGTTNPNGYANWDIDITGYAQMRRKVELFTYMRFDAEFTFVACTPTGRVVPQLLQYMFVPPGAPKPDSRDSLAWPTATNPSVFVKSSDPPAQVSVPFMSPASAYQWFYDGYPTFGEHKQEKDLEYGACPNNMMGTFSVRTVGSSKSEYSLVIRIYMRMKHVRAWIPRPMRNQNYLFKSNPNYAGDSIKPTGTSRTAITTLGKFGQQSGAIYVGNFRVVNRHLATHTDWANLVWEDSSRDLLVSSTTAQGCDTIARCNCQTGVYYCNSRRKHYPVSFSKPSLVFVEASEYYPARYQSHLMLAEGHSEPGDCGGILRCQHGVVGIVSTGGSGLVGFADVRDLLWLDEEAMEQGVSDYIKGLGRAFGTGFTDAVSREVEALKNHLIGSEGAVEKILKNLVKLISALVIVIRSDYDMVTLTATLALIGCHGSPWAWIKSKTASILGIPMAQKQSASWLKKFNDMANAAKGLEWIFNKISKFIDWLKEKIIPAAKEKVEFLNNLKQLPLLENQVSNLEQSAASQEDLEAMFGNVIYLAHFCRKFQPLYATEAKRVYALEKRMNNYMQFKSKHRIEPVCLIIRGSPGTGKSLATGIIARAIADKYRSSVYSLPPDPDHFDGYKQQVVAVMDDLCQNPDGKDMSLFCQMVSTVDFVPPMASLEEKGVSFTSKFVIASTNASNIIVPTVSDSDAIRRRFYMDCDIEVTDSYKTDLGRLDAGRAAKLCTENNTANFKRCSPLVCGKAIQLRDRKSKVRYSVDTVVSELIREYNNRSAIGNTIEALFQGPPKFRPIRISLEEKPAPDAISDLLASVDSEEVRQYCREQGWIIPETPTNVERHLNRAVLVMQSIATVVAVVSLVYVIYKLFAGFQGAYSGAPKPILKKPVLRTATVQGPSLDFALSLLRRNIRQAQTDQGHFTMLGVRDRLAILPRHSQPGKTIWVEHKLINVLDAVELVDEQGVNLELTLVTLDTNEKFRDITKCIPEVITGASDATLVINTEHIPSMFVPVGDVVQYGFLNLSGKPTHRTMMYNFPTKPGQCGGVVTSVGKIIGIHIGGNGRQAFCAGLKRSYFASEQGEIQWMKPNRETGRLNINGPTRTKLEPSVFHDVFEGNKEPAVLTSKDPRLEVDFEQALFSKYVGNTLHEPDEYVTQAALHYANQLKQLDINTSKMSMEEACYGTEYLEAIDLHTSAGYPYSALGIKKRDILDPVTRDTSRMKLYMDKYGLDLPNSTYVKDELSSLDKIRKGESRLIEASSLNDPVYPRLTFGHLYEVFHANPGTVTGSAVGCNPDVFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALELVLREIGYSEEAVSLIEGINHTHHVYRNKTYCVLGGMPSGCSGTSIFNSMINNIIIRTLLIKTFKGIDLDELKMVAYGDDVLASYPFPIDCLEWGKTGKEYGLTMTPADKSPCFNEVTWENATFLKRGFLPDHQFPFLIHPTMPMREIHESIRWTKDARNTQDHVRSLCLLAWHNGKEEYEKFVSTIRSVPIGRALAIPNLENLRRNWLELF
What is the function of this protein?
Replicates the viral genomic RNA on the surface of intracellular membranes.  May form linear arrays of subunits that propagate along a strong head-to-tail interaction called interface-I.  Covalently attaches UMP to a tyrosine of VPg, which is used to prime RNA synthesis.  The positive stranded RNA genome is first replicated at virus induced membranous vesicles, creating a dsRNA genomic replication form.  This dsRNA is then used as template to synthesize positive stranded RNA genomes.  ss(+)RNA genomes are either translated, replicated or encapsidated.  Facilitates the assembly of NLRP3 inflammasome complex and stimulates the cleavage of host pro-CASP1 and the secretion of IL-1beta (PubMed:28060938).
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the picornaviruses polyprotein family.
What are the subcellular locations of this protein?
[Capsid protein VP0]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein VP4]: Virion. SUBCELLULAR LOCATION: [Capsid protein VP2]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein VP3]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein VP1]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Protein 2B]: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably localizes to the surface of intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication. These vesicles are derived from the endoplasmic reticulum. SUBCELLULAR LOCATION: [Protein 2C]: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably localizes to the surface of intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication. These vesicles are derived from the endoplasmic reticulum. SUBCELLULAR LOCATION: [Protein 3A]: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably localizes to the surface of intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication. These vesicles are derived from the endoplasmic reticulum. SUBCELLULAR LOCATION: [Protein 3AB]: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably localizes to the surface of intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication. These vesicles are derived from the endoplasmic reticulum. SUBCELLULAR LOCATION: [Viral protein genome-linked]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Protease 3C]: Host cytoplasm. Host nucleus. SUBCELLULAR LOCATION: [Protein 3CD]: Host nucleus. Host cytoplasm. Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably localizes to the surface of intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication. These vesicles are derived from the endoplasmic reticulum. SUBCELLULAR LOCATION: [RNA-directed RNA polymerase]: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Host cytoplasm. Note=Probably localizes to the surface of intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication. These vesicles are derived from the endoplasmic reticulum.