PharMolix/UniProtQA huggingface dataset:
Protein: ATPE_RHIL3
Sequence: MADNFNFELVSPERLLLSEMVTEVVIPATEGEMTVMANHAPTMTTIKPGVVSVRSASGKKQDYVVFGGFADILPTGCTLLAESAVPVEELQKDELTRRIEAARQELEHAELHEHKSKLEHFIMEMTHLRGVVEQD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CSM4_STRTR
Sequence: MTYKLYIMTFQNAHFGSGTLDSSKLTFSADRIFSALVLESLKMGKLDAFLAEANQDKFTLTDAFPFQFGPFLPKPIGYPKHDQIDQSVDVKEVRRQAKLSKKLQFLALENVDDYLNGELFENEEHAVIDTVTKNQPHKDGNLYQVATTRFSNDTSLYVIANESDLLNELMSSLQYSGLGGKRSSGFGRFELDIQNIPLELSDRLTKNHSDKVMSLTTALPVDADLEEAMEDGHYLLTKSSGFAFSHATNENYRKQDLYKFASGSTFSKTFEGQIVDVRPLDFPHAVLNYAKPLFFKLEV
What is the function of this protein?
The subunit probably binds to the 5' handle of the crRNA, helping in discrimination between self- and non-self.
What are the official names of this protein?
CRISPR system Cms protein Csm4, CRISPR type III A-associated RAMP protein Csm4.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Csm4 family.
Protein: RECO_WOLPM
Sequence: MRWKDEGIIIAAKKYGDKNLILSLFTKNHGKRRGLTKLTNNSNYKFQISNLLHAEWSAKLPENLGFLKCELIESPFHHFFQDRLKSITIVSFSSILEKVLPESEPCAMLYDNLRYFIDVIKHNNQSWQSHYLNLELLLLTQLGFKLDLSKCAVTGVKENLQFISPKTGRAVSKKVGDYYADKLLPFPQMLHDVYNNNLQNSYSFQEFQLGLKVTGYFLNKYLFLQLNVKFPELRNLMLSL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: FRA18_FRAAN
Sequence: MGVFTYETEFTSVIPPPRLYKAFVLDADNLIPKIAPQAVKSAEIVQGDGGVGTIKKIHLGEGSEYSYVKHQIDGLDKDNFVYNYSIIEGDAIGDKVEKISYEIKLVASPSGGSIIKSTSHYHCKGEVEIKEEHVKAGKEKAAGLFKIIENHLLANPEAYN
What is the function of this protein?
Possesses ribonuclease activity in vitro.
What are the official names of this protein?
Major strawberry allergen Fra a 1.08, Class 10 plant pathogenesis-related protein Fra a 1.08, PR10-related protein Fra a 1.08.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
Protein: RK20_SORBI
Sequence: MTRVPRGYIARRRRTKMRSFASNFRGAHLRLNRMITQQVRRAFVSSHRDRGRQKRDFRRLWITRINAATRVYNVFNSYSKLIHNLSKKELILNRKMLAQVAVSNPNNLYTISNKIRTIN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EIF3B_SCLS1
Sequence: MAPSFDHLPDPEEDEYDEEELDISDLRERFEVQLEQGLDTFVVIDGLPEVNEDTKPKLIKFLLRKLDSVGQTKKDSIHMPIGPDGKSFKFAFVEYSSPAEAIAACKALDGVPLDKKHTLRVNKLTDIDRYGREGRIDENYTPPKIEEFTEKEHLRSWLADPAGRGRDQFVMYKDDRVQVFWNNEKDAPESIVDRQHWTESFVQWSPQGTFLTSMHQQGVQLWGGPSWTRQKRFAHPFVNLVDFSPGEKYLTTWSNRPISIGEEGHPALSVDDDGKNYVIWDIETGLPLRSFANLDLPSNSVDAEGNPVKRKIQWPAFKWSSDDKYVARLTQGSSISVYELPRMNLLDKTSIKIDGVMDFDWAPATPHREGVKNYEQLFCYWTPEIGSNPAKVGLMSIPSKEVVRTLNLFSVTDAKLHWQSDASYLCVKVDRHSKSKKSLATSLEIFRVKEKGVPVEVVDSIKDTVINFAWEPKGDRFVIITTAEVVAATAVPPKTSVSFFCPEKVKGNGVGNFKHIRTYDKKNSNAIYWSPKGRFVIVATVHSQQSFDMEFYDMDFEGEKPESDKDLTANLQLMNTADHYGVTDIDWDPTGRFVATSASIWKHTMENGYHLYDFKGEQLREEPVEKFKQWLWRPRPPTLLSKEEQKQIRKNLREYSKVFDQEDADRGASADLAVVEHRRRLLDEWLAWRANIEEDVQAEREDAGLPRDPLEPLKSKMASGDEGQAIEIEEIVEEIVEETEEIIS
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit B, eIF3b, Eukaryotic translation initiation factor 3 90 kDa subunit homolog, eIF3 p90, Translation initiation factor eIF3, p90 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 6PGL_MYCTU
Sequence: MSSSIEIFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQARRALLNHVDIPSNQVHPMAASDGDFGGDLDAAALAYEQVLAASAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAVLESTRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSVPAAGAVGRQNTLWLLDRDAAAKLPS
What is the function of this protein?
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6PGL.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Protein: PSAB_SYNP2
Sequence: MATKFPKFSQDLAQDPTTRRIWYGIATAHDFETHDGMTEENLYQKIFASHFGHLAIIFLWTSGTLFHVAWQGNFEQWIKDPLNVRPIAHAIWDPHFGQGAIDAFTQAGASNPVNIAYSGVYHWFYTIGMTTNADLYQGAVFLLILSSLFLFAGWLHLQPKFRPSLAWFKDAESRLNHHLAGLFGVSSLAWTGHLVHVAIPESRGVHVGWDNFLSVKPHPAGLMPFFTGNWGVYAQNPDTAGHVFGTSQGAGTAILTFLGGFHPQTESLWLTDIAHHHLAIAVLFIIAGHMYRTKFGIGHSIKEILNAHQPPSGKLGAGHKGLYDTVNNSLHFQLGLALASLGVITSLVAQHMYSLPSYAFIAKDYTTQAALYTHHQYIAGFLMVGAFAHGAIFFVRDYDPEANKDNVLYRMLEHKEALISHLSWVSLFLGFHTLGLYVHNDVVVAFGTPEKQILIEPVFAQFVQAASGKALYGFDVLLSNADSIASNASAAYLPGWLDAINSGSNSLFLNIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAMFWMLNTLGWLTFYWHWKHLGIWQGNVAQFNENSTYLMGWFRDYLWANSAQLINGYNPYGVNNLSVWAWMFLFGHLVWATGFMFLISWRGYWQELIETIVWAHERTPLANIVRWKDKPVALSIVQARLVGLAHFTVGYVLTYAAFLIASTSGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: RSMH_METEP
Sequence: MSRAPRTARAELPKGAQARHVPVLLAEVLAALSLDRPGLAVDGTFGAGGYTRALLEAGPEVRVIAIDRDPTAIRGGADLVTASGGRLRLVQGRFGDLDTLIADQDEPQADWVVLDIGVSSMQIDEAQRGFSFRQDGPLDMRMGGEGPSAADLVNGEEETTLADILYHFGEERRSRAVARAIVEARRRAPIETTAQLADLVAGVVRPEPGSPIHPATRSFQGLRIAVNDELGELVRGLHAAERVLKPGGRLAVVTFHSLEDRIVKQFFSARSGRAAQASRHVPGVERPAPKSFKLVTKGPVLPSEAETDVNPRSRSAKLRAGERTDAPAPPPLSAIETLASLPAPQGRGPRR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCUR1_HUMAN
Sequence: MDCGSVGGQRTQRLPGRQRLLFLPVGLSGRPGGSETSARRCLSALSDGLGALRPRAPAARGGVSRASPLLLLLLVPSPRLAAAAPRRQLGDWERSRLGYAAPPAGRSSAWRCSPGVAAAAGALPQYHGPAPALVSCRRELSLSAGSLQLERKRRDFTSSGSRKLYFDTHALVCLLEDNGFATQQAEIIVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDMIILEKSEFSALRAENEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEKSRVKELYSLNEKKLLELRTEIVALHAQQDRALTQTDRKIETEVAGLKTMLESHKLDNIKYLAGSIFTCLTVALGFYRLWI
What is the function of this protein?
Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564).  Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883).  Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846).
What are the official names of this protein?
Mitochondrial calcium uniporter regulator 1, MCU regulator 1, Coiled-coil domain-containing protein 90A, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the CCDC90 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RBL_MAGLA
Sequence: PVAGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEALYKAQAETGEIKGHYLNATAGTCEEMMKRAIFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGERDI
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ALF_PLAFA
Sequence: MAHCTEYMNAPKKLPADVAEELATTAQKLVQAGKGILAADESTQTIKKRFDNIKLENTIENRASYRDLLFGTKGLGKFISGAILFEETLFQKNEAGVPMVNLLHNENIIPGIKVDKGLVNIPCTDEEKSTQGLDGLAERCKEYYKAGARFAKWRTVLVIDTAKGKPTDLSIHETAWGLARYASICQQNRLVPIVEPEILADGPHSIEVCAVVTQKVLSCVFKALQENGVLLEGALLKPNMVTAGYECTAKTTTQDVGFLTVRTLRRTVPPALPGVVFLSGGQSEEEASVNLNSINALGPHPWALTFSYGRALQASVLNTWQGKKENVAKAREVLLQRAEANSLATYGKYKGGAGGENAGASLYEKKYVY
What is the function of this protein?
Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (PubMed:2190085).  Independently of its catalytic activity, connects the actin filaments, and thus the actomyosin motor, to cell surface adhesins of the thrombospondin-related anonymous protein (TRAP), the erythrocyte binding ligand (EBL) and reticulocyte binding homolog (RH) protein families; this interaction is probably involved in transducing the motor force across the parasite surface required for sporozoite and ookinete gliding motility and merozoite invasion (By similarity).  Stimulates actin polymerisation (By similarity).
What are the official names of this protein?
Fructose-bisphosphate aldolase, PfAldo, 41 kDa antigen.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Host cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MSRA_HALWD
Sequence: MSETATVGGGCFWCTEAAMKELAGVNTVTSGYAGGDIDNPTYKQVCSGTTDHAEVVQIEYDPTKIEYSELLEVFFATHDPTQLNRQGPDVGTQYRSIILTHTAEQRATAEAYIEALNDHYDDAIVTEIESLERFWSAEEYHQDYFEKNPSDAYCRMHAQPKVEKVRETFTEKLT
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: SYR_STRP3
Sequence: MDTKTLIASEIAKVVPELEQDAIFNLLETPKNSDMGDLAFPAFSLAKVLRKAPQMIASELAEQIDESQFEKVVAVGPYINFFLDKAKISSQVLEQVITAGSDYAQQDEGQGRNVAIDMSSPNIAKPFSIGHLRSTVIGDSLAHIFAKMGYKPVKINHLGDWGKQFGMLIVAYKKWGDEAAVQAHPIDELLKLYVRINAEAETDPTVDEEAREWFRKLEDGDKEATELWQWFRDESLLEFNRLYDQLHVTFDSYNGEAFYNDKMDEVLELLEAKNLLVESKGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKRTYDFAKSVYVVGNEQAAHFKQLKAVLKEMGYDWSDDMTHVAFGLVTKGGAKLSTRKGNVILLEPTVAEAINRAASQIEAKNPNLADKEAVAHAVGVGAIKFYDLKTDRMNGYDFDLEAMVSFEGETGPYVQYAHARIQSILRKADFTPSATTTYSLADAESWEIIKLIQDFPRIIKRTSDNFEPSIMAKFAINLAQSFNKYYAHTRILDDNSERDNRLALCYATATVLKEALRLLGVDAPNEM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y086_RHOPS
Sequence: MADFLGMMKQAAQLQSKMKAMQAELDQIEVEGSSGGGLVQVRMSAKMEVRGVSIDPSLLKPDEGGVLEDLLVAAHADAHRKAEAAMQEKMQALTGGLGLPPGLGLG
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein RPD_0086.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CRS2L_ORYSJ
Sequence: MAMTAASVFGSGGCLELLTSSKAMRGKLWTRLAPFISKRHASTSQTSLSSSSSSCSVINPWLFVGLGNPGEKYQCTRHNVGFDMIDMFAQSQGISLTRHPFKALFGEGMVEGVPVLLAKPQTYMNLSGESVGPLAAYYKLPLNRVLVAFDDMDLPCGVLRLQPKGGYGRHNGSVDFIIMCFNEVIC
What are the official names of this protein?
CRS2-like protein, chloroplastic, Chloroplastic RNA splicing factor 2-like protein.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NAGB_VIBC3
Sequence: MRLIPLKAAAQVGKWAAAHIVKRINEFQPTAERPFVLGLPTGGTPLATYKALIEMHKAGEVSFKHVVTFNMDEYVGLAADHPESYRSFMYNNFFNHIDIQEENINLLNGNTDDHEAECKRYEDKIKSYGKINLFMGGVGNDGHIAFNEPASSLSSRTRIKTLTEDTRIANSRFFDGDINQVPKYALTIGVGTLLDAQEIMILVTGHNKALALQAAVEGSVNHLWTVSALQLHPKAVIVCDEPSTQELKVKTVKYFTELEAKNIVGF
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: KPRS_AERPE
Sequence: MEGPEQWVIVGGWGSASAEFSEGLSRNMGLKLVKPVFKLFPDEEEYVRIEGDISGFTGAIVVQSFERPASRSLVYSLLIADALKEAGVGRIVLMAPYMGYTRQDRVFLPGEPVSVRAVMRALASSGYNALASIEVHKEYVLDYFDGSTLNIFPFTYMLKETGISCGDNTIIVAPDKGSLPRVERLARETGCRSYGYLVKERDRITGEVRLAKSTVDPRGKNAIVVDDIISTGGTIALASQWLLENGANSVFVLAAHYLGIGNAEEKMMKAGVSRVVTGNTLPRKPSKIVTYVDLTGLAAGQLTKLVSNL
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALG13_CANAL
Sequence: MFDWRRLKPLRPHQIFFFYTTIQNYSDNGYQYSYKSNQIKSNQIKLNQQQQTSRQLIRINNQLPPSVVLHNIIMKSILITTGATITFKSLIQIILSPQFLNNLIRLKINKLIIQYGHEIKNSINLSESFFNETINKYDLINLFNLEIEETPIGDDDDDEGIRLFKNSDIEILAFSYSSNINKYIENVDLIISHAGTGSIIDCLHLNKPLIVIVNDKLMDNHQLEIAQQFTKLNYCIYYSIKELEQYVNNNDNNKDSRFWNQLNQLINGELQLNKLPQTDGSIIETIICEELEK
What is the function of this protein?
Involved in protein N-glycosylation.  Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity).
What are the official names of this protein?
UDP-N-acetylglucosamine transferase subunit ALG13, Asparagine-linked glycosylation protein 13.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: GLMS_CLOPE
Sequence: MCGIVGYVGQKKATDILVEGLSKLEYRGYDSAGVAVLEDNKIKAEKHKGRLANLEGMLNENPIEGGIGIGHTRWATHGEPSDVNSHPHLNNKETIAVVHNGIIENYNELRNWLMEKGYEFKSETDTEVIPNLVDFYYKGDLLDAVMEATKHMEGSYAIGVICNDEPEKLVAVRKDSPLIVGLGEKEYFIASDIPAVLNHTREVYLLEDKEFVVLTNDGVTLFDEEKNPVEKEVYHITWNVDAAEKGGYEDFMLKEINEQPKAIKDTMTSRIMEEKEVTLDDISITKEYLDNVDRVYIVACGTAYHAGVIGKYAIEKLVRIPVEVDIASEFRYRDAVITDKTLIIVLSQSGETADTLAVLRDGQAKGARVLAVTNVVGSSVSREANDVLYTWAGPEIAVASTKAYVTQLIAMYTLALHFAELKGSKSVEEIEEIKKAMLELPEKVEEILKNTDLIKEFAVKASTEKDLYFLGRGMDYGVAMEGSLKLKEISYIHSEAYAGGELKHGPIALIEKDIPVISLLTQRELMDKMISNVQEVVTRGANVLGVCFKGDMEESKRKMFEGLIEIPETLSLLSPVLSVVPLQLFSYYVAKAKGFDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_METVS
Sequence: MKVFYDADIKLDALKSKTIAVIGYGSQGRAQSLNMKDSGLNVVVGLRKNGASWENAKNDGHEVLTIEEASKKADIIHILIPDELQAEVYESQIKPYLTEGKTLSFSHGFNIHYGFIIPPKGVNVVLVAPKSPGKMVRKTYEEGFGVPGLICIEVDATNTAFETVSAMAKGIGLSRAGVIQTTFREETETDLFGEQAVLCGGVTELIKAGFETLVEAGYSPEMAYFETCHELKLIVDLIYQKGFKNMWHDVSNTAEYGGLTRRSRIVTADSKAAMKEILKEIQDGRFTKEFVLENQAKMAHLKAMRRLEGELQIEEVGSKLRKMCGLEKDE
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SSRP_MYCSJ
Sequence: MAAKKAGKAGATKDRNNQVVASNRRARHNYAILDTYEAGIALMGTEVKSLRDGQASLADAFATVDDGEIWLRNLHIPEYQHGSWTNHAPRRNRKLLLHRREIDNLIGKIRDGNLTLVPLSLYFTGGKVKVELALARGKQAHDKRQDLARRDAEREVVRELGRRAKGMS
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RL16_STRPZ
Sequence: MLVPKRVKHRREFRGKMRGEAKGGKEVSFGEYGLQATTSHWITNRQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKVMFEIAGVSEEIAREALRLASHKLPVKCKFVKREAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: END3_RICPR
Sequence: MQAQIMNKIFEIFSKNNPKPQTELIYKNDFTLLVAVILSARATDISVNLATKHLFETYNTPEKFLELGEEGLKKYIKSIGLFNSKAKNIIALCQILIKNYQTSIPNNFKELVKLPGVGRKTANVVLNCLFAMPTMAVDTHVFRVSKRIGLAKGNTAAIVEKELLQIIDEKWLTYAHHWLILHGRYICKARKPGCNICPIKEYCEYYINTFSS
What is the function of this protein?
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity.  The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site.  The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
What are the official names of this protein?
Endonuclease III, DNA-(apurinic or apyrimidinic site) lyase.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
Protein: PHF5A_MOUSE
Sequence: MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR
What is the function of this protein?
Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency.  Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells.  Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes.  Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes.  Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies.  Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (PubMed:27749823).  Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex.  SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.  Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity).  Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (By similarity).  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
What are the official names of this protein?
PHD finger-like domain-containing protein 5A, PHD finger-like domain protein 5A, Splicing factor 3B-associated 14 kDa protein, SF3b14b.
What is the protein family that this protein belongs to?
Belongs to the PHF5 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.