Protein: DPY21_CAEEL
Sequence: MRSTTFDKNSGAPEEPRRPRGPRTPDGEPTEANERPCSSSSSLSNDSFVPAPQGPQNGHTSSSHDNDYSEYRPRRGPKTPPLPPPDEPVKQQQQQQPIVAPYSYYPTYGSSTGYPYPYPTMMMPQQGIPGPSQHPATPSYYIQHPPPPSMSNGAPYYPHMNPSPYYQPRPNYVTQPPAPIIPPPQPPVMTASAAAAAYRDRLPPPPPKPPMPDLRTKEPIGIRSWNGSGIPPPPILPPVACLSSTMSPGMLRSPVPRERFNSVESNGSFSLHPPPPVPPPAKKPLNMDVRELLNGAHQTTVESVKKDPPAPQPRPRPIPVPPTTSYNSSFCGLLPPPPVPPDLRASAASAAASPPMVQDASFSSVLTPKTKAPEKIPSPPATVTSSTDSLEHMQRKRKKQQETEEQEKAAKKAKRHQEERERQKIEAEKRKKAILEEAAKVTRPPAEKKPPVVVEETIRAVPFVFKQEMPLPFVLAAAAAAAKEPETRPEPRPEPKQNGYHVKQAEPLQAEPPQNGYRLAAAQALQHEPRQASEPLQNVQPEPSKQASELVQNGYAAPQEPRRATPPPEPLRNELPKHSDLLNVSKPSEPAEPPKPSDAPREPEVAAAEAVIPEPSPAVSVEEPPRREERAASMAGIPPPPPTSSRHSPVPRREDRAEFMARSTPPAPGKDRKSLGGRMAMWRNKKNKTASMVGPPEPKELPAVVEVEAIVEPVVEDQPEPVVSEELKPTEPEPVEPEPMEVEPVVAKEVVEEVVEEVVETQEPWVPLSECSRSSSLELLAELPPPPRASEPPPPPPPPVATAPVPASMEEDEIIDIETIDEITSTSTKKPEKVEKIKKAPVVTKAALKMVGRPKKTPGRRRKKDRGASPSPSPSPPPPPETTLTPIVLPRKKQRIEKKKLTPPPPQQAPVTSHTPPPVEQLMSRKKQIMMEHSSLDHIQFKLIEIELAAKRRKAEAAAKAAAAVEQKDEKAEEVENRETPPGPSTSMRSSSLHTPNTSEEDEVIFVEPSTLEKPERRNGTTEERVMTADQRAMFDAKIEEARRSRMSTRDCSVVSTLGPVKSKASQRLHDIIEGKEELEDSMDDPTNNNGTLAGILYPMRSERAESVSSNHRSEGAGGSMSLKHHLARKNELKEEANVARRSEILKAVVKRQREIGVPTTLMSKSAIELVEEDEKERKNHKNNKTLSHPDYVRSKNEAEKAEFHGKGGTMRITNRNLKMLTRQFDLPKMSSRFRKFVRIRRHPNGMATIISCDYNQIKQHLGPNEMKHFERQFVRLGFAENNGVPLFAIGVMENAAEALHDQFEWLAKNSPNTQVKVGSLTNKQFIETMPMKKYYESAMETLDMGTFRFGPLMSLSMVGTKNEEAGGNFKEMLDALNAAPFLGPIMPWGDFSEVQGIKEDTSDDGPIFWVRPGEQMVPTDGKNRSTEPRHPLATRGNDRRETAFNDRTNAHADQVRESTEDDPTTTTTTTTTTSSSSSSSKSKKSAKSDPTFVKSTAAVGVLQGIRNPDANDDDEYYEDERKAVKEVIVFDAHDLHKVAHHLAMDLYEPPVSQCHRWVDDAILNTMRREGIRYAKLELHENDMYFLPRNVIHQFRTVSACSSVAWHVRLRHYYDVDQPASLSDPQFECDSDYSDDGDFDD
What is the function of this protein?
Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating the chromosome architecture (PubMed:28867287).  Promotes chromatin compaction by converting H4k20me2 to H4K20me1 leading to transcriptional repression (PubMed:28867287).  Required for X chromosome dosage compensation by enriching H4K20me1 on X chromosomes and thereby reducing X-linked gene transcription in hermaphrodites throughout development (PubMed:14660541, PubMed:23028348, PubMed:3779843, PubMed:3478715, PubMed:26641248, PubMed:22393255, PubMed:28867287).  X chromosome specificity is mediated by the recruitment through proteins of the condensin-like dosage compensation complex (DCC) (PubMed:14660541, PubMed:28867287).  Required for the enrichment of H4K20me1 on autosomes in meiotic germ cells leading to their compaction in a DCC-independent mechanism (PubMed:28867287).  Involved in 3-dimensional chromosome organization by strengthening the borders of topologically associating domains (PubMed:28867287).  Involved in the regulation of growth, fecundity and body fat metabolism downstream of the TOR complex 2 and the protein kinase sgk-1 pathway (PubMed:23884442).  Also involved in male tail development (PubMed:6537930).
What are the official names of this protein?
Lysine-specific demethylase 9, KDM9, Dosage compensation protein dpy-21.
What is the protein family that this protein belongs to?
Belongs to the round spermatid basic protein 1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Specifically localizes to the X chromosomes around the 300- to 350-cell stage in hermaphrodite (XX) but not in male (X0) embryos (PubMed:14660541, PubMed:28867287). Requires sdc-2, sdc-3, dpy-26, dpy-27 and dpy-28 for X chromosome localization (PubMed:14660541). Colocalizes with X chromosomes during interphase, but is diffusely distributed during mitosis (PubMed:28867287). Localizes to all autosomes but not to X chromosomes in pachytene nuclei (PubMed:28867287).