PharMolix/UniProtQA huggingface dataset:
Protein: RLMH_RUEST
Sequence: MRVHICAVGRLRAGPEKTLIDDYLQRFDRSGRALGLGPARVIEVEDKKNAGMGAEADLLRKALPKGALICTLDERGKVISSPDFAEKLAGWRDMGRQDLAFVIGGADGIDPSLRAEADFSISFGKMVWPHMMVRLMLAEQVYRSATILSGSPYHRV
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAN2_FUSV7
Sequence: MSKTSVDKLLRIPQSLRDSISRTRVDYRHLGNCGLRVSNPILGGLHIGNSRWLPWVLNEEDAMPILKAAYDRGINTWDTANVYSNGESEKVIAKALRKYNIPRSKVILMTKCYRVVCDSENFDPGSGVTMHHELADKSKDYVNQWGLSRAAIFNAVEASLERLGTHYIDIFQIHRFDPTVPIAETMSALNDLVKAGMVRYLGASSMWTYQFAAMQNLAHAKGWTKFVSMQNHYNLIYREEEREMIRYCNDTGVGLIPWAPLASGRLARRPSQQSVSIRASNSRNGSIYEADDSNTDKIVSRVEEIAVKRNWPMSHVALAWLNKRVTAPIIGFSTVQRIEEALAAVGKELSEDEERYLEELYAPRPIQGHS
What is the function of this protein?
Aldo-keto reductase; part of the gene cluster that mediates the biosynthesis of sansalvamide, a cyclic pentadepsipeptide that shows promising results as potential anti-cancer drug (PubMed:26936154).  The nonribosmal peptide synthetase NRPS30 produces sansalvamide by incorporating successively one phenylalanine, one leucine, one alpha-hydroxyisocaproic acid (HICA), one valine and one leucine before sansalvamide is released from by cyclization by the terminal C domain of NRPS30 (PubMed:26936154).  The HICA residue is probably provided by reduction of alpha-ketoisocaproate by the cluster-specific aldo-keto reductase (NECHADRAFT_45914) (Probable).
What are the official names of this protein?
Aldo-keto reductase NECHADRAFT_45914, Sansalvamide biosynthesis cluster protein NECHADRAFT_45914.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: RUVB_MARMS
Sequence: MIEQDRIISAELKGNDRQVDRAIRPQALAEYIGQPVVREQMEIFIQAARQRGEPLDHTLIFGPPGLGKTTLANIIGNEMGAEVRTTSGPVLERAGDLAALLTNLNEGDILFIDEIHRLSPAIEEVLYPAMEDYQLDIMIGEGPAARSIKIELPPFTLVGATTRAGLLTSPLRDRFGIVQRLEFYDVESLTTIVARSAGKMGVELDQSGCFEVARRSRGTPRIANRLLRRVRDVAQVSGEVLVGQKVAQRALDMLSVDSQGFDHLDRRMLLTMIEKFDGRPVGLDSVSAALGEDKDTIEDVIEPFLIQQGFIIRTPRGRQVTKRAYEHFNYQLPSDFK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RL33_UREPA
Sequence: MAIKRGVRLQCNESKSINYITTKNAKNNPDRLSLNKFCPKCRKVTTHVEIKKK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: SUCC_SINMW
Sequence: MNIHEYQAKALLKSYGAPVAEGVAIFSADEAAAAAKKLPGPLYVVKSQIHAGGRGKGKFKELGADAKGGVRLAKSADEVVAHAREMLGNTLVTKQTGPSGKQVNRLYIEDGADIDRELYLSILVDRSVGQVAFVVSTEGGMDIEAVAEHTPEKIVTVAIDPDKGVTADDLKTLTEALKLDGEARADAEKLFPILYKAFVEKDMSLLEVNPLIVMTNGRMRVLDAKVSFDGNALFRHEDVVALRDTTEEDEKEIEASKYDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGAEPANFLDVGGGASKEKVTQAFKIITADPAVKGILVNIFGGIMKCDVIAEGVIAAVKEVGLKVPLVVRLEGTNVELGKKIINESGLNVISADDLDDAAQKIVAAVKGA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: AROC_ALCBS
Sequence: MAGNSFGERFKITTFGESHGPALGAIVDGCPPGLEISEEDLQVELDRRKPGTSRYTTQRREPDQVKILSGVFEGKTTGTTIGLLIENTDQKSKDYSNIAGTFRPGHADYTYTQKYGFRDYRGGGRSSARETAMRVAGGAIARKFLEQRLGIRIYGGCTQIGDVKAESLDWSTVNNNPFFFPDESKVPALEDLINALRKDGSSIGARVEVFADGVPPGWGEPVFDRIDADLAKAMMSINAVKGVEIGDGFAVVNQRGEQHRDEMTPQGFLSNHSGGVLGGISSGQTMRVAMALKPTSSILIAGKSIGLNGEAAEVVTKGRHDPCVGVRATPIAEAMLAIVLLDHYLRHRGQNADVVPPFPPIPG
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RL1_BDEBA
Sequence: MAGKKFAAVAKKVDSAKKYTVEEAFKLVVETAPAKFDESIDVALRLGIDPKQSDQQVRGAIALPHGLGKEVKVVVFAKGPKEAEAKAAGADFVGADDLVAKIQGGWLDFDKCIATPDMMATVSKVAKILGPRGLMPNPKIGTVTMNVGEAVTAEKKGKLDFRVDKAGIVHAGIGKKSMGDAKLKDNFMTLLGAIVKAKPASSKGIYLRSIAVASTMGPGVKIEPNAAAAATGAN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: LALBA_RAT
Sequence: MMRFVPLFLACISLPAFQATEFTKCEVSHAIEDMDGYQGISLLEWTCVLFHTSGYDSQAIVKNNGSTEYGLFQISNRNWCKSSEFPESENICDISCDKFLDDELADDIVCAKKIVAIKGIDYWKAHKPMCSEKLEQWRCEKPGAPALVVPALNSETPVP
What is the function of this protein?
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme.  This enables LS to synthesize lactose, the major carbohydrate component of milk.  In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
What are the official names of this protein?
Alpha-lactalbumin, Lactose synthase B protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLME_SALPK
Sequence: MTGKKRSASSSRWLQEHFSDKYVQQAQKKGLRSRAWFKLDEIQQSDKLFKPGMTVVDLGAAPGGWSQYVVTQIGGKGRIIACDLLPMDPIVGVDFLQGDFRDELVMKALLERVGDSKVQVVMSDMAPNMSGTPAVDIPRAMYLVELALEMCRDVLAPGGSFVVKVFQGEGFDEYLREIRSLFTKVKIRKPDSSRARSREVYIVATGRK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR_STRP8
Sequence: MISSFHRPTVARVNLQAIKENVASVQKHIPLGVKTYAVVKADAYGHGAVQVSKALLPQVDGYCVSNLDEALQLRQAGIDKEILILGVLLPNELKLAITRQVTVTVASLEWLAMAKQEWPDLKGLKVHIKIDSGMGRIGLRSVTEVDNLIAGLKSMGADVEGIFTHFATADEADDTKFNQQLQFFKKLIAGLEDKPRLVHASNSATSIWHSDTIFNAVRLGIVSYGLNPSGSDLSLPFPLQEALSLESSLVHVKMISAGDTVGYGATYTAKKSEYVGTVPIGYADGWTRNMQGFSVLVDGQFCEIIGRVSMDQLTIRLSKAYPLGTKVTLIGSNQQKNISTTDIANYRNTINYEVLCLLSDRIPRIY
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: Y552_BIFA0
Sequence: MLNILEVHETNQMIEQEKLDVRTITMGIDLMDCVSTDLQTTCDLIYNKITSYAKDLVSTGESIERDFGIPIVNKRITVTPIALVGASCCKTSADFVQIAHALDRAAKTVGVDLIGGYSALVSKSMTPAEELLIRSLPAALSETDIVCSSVNVGSTKTGIDMNSVELLGHIIKEIAEATADIDSYGCVKFVAFCNAPDDNPFMAGGFHGVTEGDAVINVGVSGPGVVSRALDAAKGKDFEFLCETIKRTAFKITRVGQLVAQEASKRLGIPFGIIDLSLAPTPAVGDSVGEVLEKIGLAQVGAPGTTAALAMLNDQVKKGGIMASSYVGGLSGAFIPVSEDKNMIDAAESGCLTIEKLEAMTCVCSVGLDMIAIPGDTTASTISGIIADEAAIGMVNQKTTAVRVIPVVGKTVGQMANFGGLMGYAPIMPVNTASCEAFVTRGGRIPAPIHSFKN
What are the official names of this protein?
UPF0210 protein BLA_0552.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: DNLJ_MANSM
Sequence: MTIMDINQQIKQLRDTLRYHEYQYHVLDDPKIPDAEYDRLFHQLKALEQQHPELITADSPTQRVGAKPLAGFAQITHELPMLSLDNAFSDEEFNAFVKRIQDRLIVLPQPLTFCCEPKLDGLAVSIFYVNGVLTQAATRGDGTTGEDITLNIRTIRNIPLQLLTDNPPARLEVRGEVFMPHEGFNRLNERALEHGEKTFANPRNAAAGSLRQLDPKITSRRPLVFNAYSVGIAEGVELPATHYERLQWLKSVGIPVNSEVQLCDGSEKVLEFYRSMQQKRPTLGYDIDGTVLKINDIGLQRELGFISKAPRWAIAYKFPAQEELTRLNDVEFQVGRTGAITPVAKLAPVFVAGVTVSNATLHNGDEIARLDIAIGDTVVIRRAGDVIPQIIGVLHERRPANAQAIVFPTQCPVCGSKIVRIEGEAVARCTGGLFCDAQRKEALKHFVSRRAMDIDGVGAKLIEQLVDKELIRTPADLFKLDLITLMRLERMGEKSAQNALDSLEKAKNTTLARFIFALGIREVGEATALNLANHFKNLDALQAASPEQLQEVADVGEVVANRIYVFWREQHNIDAVNDLIAQGIHWETVETKEAGENPFKGKTVVLTGTLTQMGRNETKDLLQQLGAKAAGSVSAKTHFVIAGDNAGSKLTKAQELGVAVMSEAEFLAIVNAYKR
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: NDUF3_RAT
Sequence: MATALGFRCLYRTRPATLGRYVDRLWRSPSRGHRLSPADDELYQRTRISLLQNEFPQAVYIDSYNSRGFTINGNRVFGPCALLPQTVVQWNVGSHQDITEESFSIFWMLEPRIEIVVVGTGNKTERLHSQVLQAMRQRGIAVEIQDTPNACATFNFLCHEGRVTGAALIPPPGETALASSGQTTE
What is the function of this protein?
Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3, Nuclear protein E3-3.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Nucleus.
Protein: SECE_STAAW
Sequence: MAKKESFFKGVKSEMEKTSWPTKEELFKYTVIVVSTVIFFLVFFYALDLGITALKNLLFG
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ABR_RAT
Sequence: MEPLSHRGLPRLSWIDTLYSNFSYGAEDYDAEGHEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGESISPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEMSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKVKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTTEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVESKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
What is the function of this protein?
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins.  The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42.  Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form.  The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1.  Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity).  Functions as an important negative regulator of neuronal RAC1 activity (By similarity).  Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity).
What are the official names of this protein?
Active breakpoint cluster region-related protein.
What are the subcellular locations of this protein?
Cell projection, dendritic spine. Cell projection, axon. Synapse.
Protein: LST_PASMU
Sequence: MNLIICCTPLQVLIAEKIIAKFPHMPFYGVMLSTVSNKKFDFYAKRLAQQCQGFFSMVQHKDRFNLLKEILYLKRTFSGKHFDQVFVANINDLQIQFLLSAIDFNLLNTFDDGTINIVPNSLFYQDDPATLQRKLINVLLGNKYSIQSLRALSHTHYTIYKGFKNIIERVEPIELVAADNSEKVTSAVINVLLGQPVFAEDERNIALAERVIKQFNIHYYLPHPREKYRLAQVNYIDTELIFEDYILQQCQTHKYCVYTYFSSAIINIMNKSDNIEVVALKIDTENPAYDACYDLFDELGVNVIDIRE
What is the function of this protein?
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to lactosyl lipids as preferred acceptor substrates in vitro, forming alpha-2,3-linked sialosides.  Beta-1,4-linked galactosyl lipids are better substrates than beta-1,3-linked galactosyl lipids.  The natural acceptor substrate may be cell surface oligosaccharides in lipooligosaccharide (LOS), whose sialylation has been demonstrated vital for the virulence of P. multocida.
What are the official names of this protein?
CMP-N-acetylneuraminate:beta-galactoside alpha-2,3-sialyltransferase, CMP-Neu5Ac:beta-galactoside alpha-2,3-sialyltransferase, Glycolipid alpha-2,3-sialyltransferase, PmST2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 52 family.
Protein: YCR2_PSEVU
Sequence: MSELIEHANAIEWRFERQILRLEPWGKNSLRVRATCAPEFTSALHALLTPESCQAEILRDAETLTLRNGNISAVLNLKGQLAFYNQRGELLLEEMWRQRSTVGIGASEKSQDKYVSALKLDGREFKPLPGGKYQLTVRFEARQGEKLYGMGQYQQPWLDLKGCSLELAQRNSQASVPFVQSSLGYGLLWNNPAIGEASFAKNHSQWTSRVTQEMDYWITAGDSVMEITRQYAKATGTPPAAPEFISGLWQCKLRYRTQQEVLDVAREYHRRNLPLSVMVIDFFHWPNQGTWCFDPVDWPDPRAMVEELESMGIRLMVSVWPTVEARSPLFPQMKAKGWLVTSDRGVQVNLDFMGNTTFFDATHPQARQFVWDTVKKNYFDYGIKLFWLDEAEPEYRAYDFDNYRYHAGPVLEVGNRYPRDFAQGFYDGLRAEGENEIVNLVRCSWAGSQRYGVLAWSGDVHSSFHSFRNQLAAGLNMGLAGIPWWTTDIGGFQGGNIHDPAFHELLIRWFQWAVFCPVLRMHGYREPRI
What are the official names of this protein?
Uncharacterized family 31 glucosidase ORF2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 31 family.
Protein: Y1513_LISMC
Sequence: MDSKDQTMFYNFGDDSIEEDVKKLMKQVYVALEEKGYNPVNQIVGYLLSGDPAYIPRHKDARSMIRRLERDEIIEELVKAYLKNNEIGEK
What are the official names of this protein?
UPF0297 protein Lm4b_01513.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: SHRM4_HUMAN
Sequence: MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVNINGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFPSEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQNMYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGSRRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASEPVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLMQASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASHLQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQVDDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDCSSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRKAQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMMLRARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCGVRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEESSKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHATDQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDPCIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPRKLTVQEFPGDKWNPITGNRKTSQSGREMAHSKTSFSWATPFHPCLENPALDLSSYRAISSLDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRRELFSKGDETQSDLLGARKKAFPPPRPPPPNWEKYRLFRAAQQQKQQQQQQKQQEEEEEEEEEEEEEEEEEEEEAEEEEEELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLPPIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYYNISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQEKLVLIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLRESLLLGPSNF
What is the function of this protein?
Probable regulator of cytoskeletal architecture that plays an important role in development.  May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity).
What are the official names of this protein?
Protein Shroom4, Second homolog of apical protein.
What is the protein family that this protein belongs to?
Belongs to the shroom family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Shows partial colocalization with the cytoplasmic pool of F-actin.
Protein: RHBG_TAKRU
Sequence: MTDAATNMRLKLPITCFILEIILIILFGTLVQYDYETDAKEWHNTSHQDYENDFYFRYPSFQDVHVMIFVGFGFLMTFLQRYGFGSVGFNFLIAAFSLQWATLMQGFFHGMHGGKIHIGVESMINADFCTGSVLISFGAVLGKTSPIQLLTMAIFEVTLFAVNEFILLSLLGTKDAGGSMTIHTFGAYFGLMVTRILYRPNLDKSKHRNSSVYHSDLFAMIGTVYLWMFWPSFNSAITAHGDDQHRTALNTYYSLAACTLATYGMSAITSHDGKLDMVHIQNAALAGGVAVGTAGEMMLTPFGSMIVGFMAGIISVLGFKFLSPILEDKLKIQDTCGIHNLHGMPGVLGAIVGAVTAALATTDVYGQGMADVFPAVADGSVNATKQGGIQALSLAITLGIAVLGGLIVGFVLKLPVFGTPPDTLCFEDSVYWEVPGSESPEEGELTSVKPEETEHLNS
What is the function of this protein?
Functions as an ammonia transporter.  May play a role in the elimination of ammonia in the gill.
What are the official names of this protein?
Ammonium transporter Rh type B, FRhbg, Rhesus blood group family type B glycoprotein, Rh family type B glycoprotein, Rh type B glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
What are the subcellular locations of this protein?
Apicolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: BHE22_MOUSE
Sequence: MERGLHLGAAAASEDDLFLHKSLGTSAAKRLEAAFRSTPPGMDLSLAPPTRERPASSSSPLGCFEPADPEGAGLRLPPPGGGGGASGGGGGVSVPGLLVGSAGVGGEPSLSSLPAGAALCLKYGESAGRGSVAESSGGEQSPDDDSDGLCELVLRAGGPDPRASPRAGGGSAKVAEGCSNAHLHGGSGLPPGGPTSGGGSGGGGGGSSKKSKEQKALRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQAISAASLPSSAAAAAAAAALHPALGAYEQAAGYPFSAGLPPAASCPEKCALFNSVSSSLCKQCTEKP
What is the function of this protein?
Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors.  Despite the presence of an intact basic domain, does not bind to DNA (By similarity).  In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization.  May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis.  Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes.  Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184).
What are the official names of this protein?
Class E basic helix-loop-helix protein 22, bHLHe22, Class B basic helix-loop-helix protein 5, bHLHb5, Protein BETA3.
What are the subcellular locations of this protein?
Nucleus.
Protein: NIFW2_TRIV2
Sequence: MTWDIEQFNKLVSAEEYFEFFQLPYDPRVVQVSRLHILKQFSQSIQEIDANNSQASQAEKLDLYCTALKQAYEVFLSSTPLEQKLFKVFKQKPKNIVMLTEIATS
What is the function of this protein?
May protect the nitrogenase Fe-Mo protein from oxidative damage.
What are the official names of this protein?
Nitrogenase-stabilizing/protective protein NifW 2.
What is the protein family that this protein belongs to?
Belongs to the NifW family.
Protein: WIPI2_HUMAN
Sequence: MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
What is the function of this protein?
Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy.  Isoform 4 is also required for autophagic clearance of pathogenic bacteria.  Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
What are the official names of this protein?
WD repeat domain phosphoinositide-interacting protein 2, WIPI-2, WIPI49-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
Protein: RS10_LACP3
Sequence: MAKQKIRIRLKAYEHRILDQSADKIVETAKRTGATISGPIPLPTERTLYTVLRSPHKYKDSREQFEMRTHKRLIDIVNPTPKTVDALMKLDLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RECX_LISMC
Sequence: MKITSISVQQKNKERYNIFIDEKYNFSVDEEVLARYQLMKGKVLTEAKIEEIKQADMVRKGLNKAINFLSHRVRSEKEIRDYLRKQEMEAFAIDEILKKLADMDYINDLEFAELYTKTQIKTTLKGPRTIERELVEKGLTREIITQVIEEYSDEAQLENATKQAIKIMKRNNKSAKKMLQQKIITDLIQKGYTSELAKVAATEATSELDVADEAEILQKQIEKTMRKNKRYKPSIAKQKTITSLMQKGFSYDTIQSYLTENEISFEEEE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.