PharMolix/UniProtQA huggingface dataset:
Protein: SPED_YERPS
Sequence: MSKLKLHGFNNLTKSLSFCIYDICYAKTADDRDGYIAYIDEQYNANRLTEILSETCSIIGANILNIARQDYDPQGASVTILVSEEPVDPRDVDTSEHPGPLPSAVVAHLDKSHICVHTYPESHPEAGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTMDYRVRGFTRDINGVKHFIDHKINSIQNFMSDDMKSLYHMMDVNVYQENIFHTKMMLKDFDLKHYLFNAKPEELSAEEKEQITCLLYKEMQEIYYGRNVPEV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: DER_NITWN
Sequence: MSFTIAIIGRPNVGKSTLFNRLVGQKLALVDDEPGVTRDRREGQARLGDLDFTVIDTAGLDEGPRGSLTARMQEQTEAAIAAADALMFVFDARAGLTPTDRSFADFARRADKPVVLVANKSEGRHGDAGALESYALGLGDPVGVSAEHDEGMSDLYDALRSVMPEPAEEVDEEEIVEPDMSRPIRVAIVGRPNAGKSTVINYLLSEERLLTSPEAGTTRDSISVELNWKGRDFRIFDTAGLRRRSRIEAKLEKLSVADTLRAVRFAEAVVLMMDAQNRFEEQDLRIADLIEREGRALVIAVNKWDLMKGGSARIASLRNDVDHWLPQIRGAPVVAISGLTGEGIDRLMIAIQTAYAVWNRRVATALLNRWFQQAVAASPPPAVSGRRLKLNYATQTKARPPSFVVFCSRADAVPESYLRYLVNSLRETFDLAGTPIRITLREKANPFAHKRKRKS
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PHF6_MOUSE
Sequence: MSSSIEQKKGSTRQRKCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEESFNEHELEPSSPKTKKKSRKGRPRKTNLKGLPEDSRSTSSHGTDEMESSSYRDRSPHRSSPNDTRPKCGFCHVGEEENEARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDERDEEDEERESKSRGRVAIDQQLTQQQLNGN
What is the function of this protein?
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.
What are the official names of this protein?
PHD finger protein 6.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Chromosome, centromere, kinetochore. Note=Nuclear, it particularly localizes to the nucleolus.
Protein: ERT1_ZYGRC
Sequence: MGGGSGPSDEFANILPHFSQVDSSVPVSSGKKSRRNTHVACVNCSKWHVSCEAKRPCHRCVVKGLGSTCVDAPRKKSKYLAGIPDASLIRSVHRDNGSQANNSSPDNAGVSHHQEQQNFRDPQHIVHKSKFLSNAADSEYSILSHIINQDTLVNKIPIDLLYSGKPNDNDAEAAAAVAAKEAANVDLSSPKVDVGPSNTAMSSTDVYSMLLGPNSREIVASRIDLFQNHFPLTPVESQYHSLSFKRLPTQDRSGSPKFNASINQYYLNKEISMLPEVINAAMRQQRSVGDKSVSFALECVSPDAYQLSGNSEWRHSLRYSTSMEIYQLINEPFSHTTGFHHLYTYLRKRFNRKDLIEMSGCLAEFRPIFIACTASLTEQDMIFMEQCYQRTLLEYAKFIAQIGTPTCVWRRNGQISYVNEEFEILSGWNKEELLNKMTFIVEIMDDESVRDYFKTFAKVAYKDFRGSERMKTCNLLTPTRGQIIPCCCMWTLKRDVSGLPLMILGNFMPIIA
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes (By similarity).
What are the official names of this protein?
Transcription activator of gluconeogenesis.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MGSA_THET8
Sequence: MKALALIAHDAKKDEMVAFCLRHKDVLARYPLLATGTTGARIQEATGLAVERVLSGPLGGDLQIGARVAEGKVLAVVFLQDPLTAKPHEPDVQALMRVCNVHGVPLATNLVAAEALIAWIRKGTPQ
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: ERA_DINSH
Sequence: MTENAAPTRAGFVALIGEPNAGKSTLTNAMVGAKVSIVTHKVQTTRARIRGVALEGAAQIVFVDTPGLFRPRRRLDRAMVAAAWGGAADADIVVLMVEAHRGMTDGVRAILETLNERRDPKQIVALAINKIDRVKSEVLLKLTQDLNAAYPFAETFMISAEKGYGVADLRAWLGASLPEGPWMYPEDQIADVPLRMIAAEITREKLTLRLHQELPYQLTVETENWEERKDGSVRIDQVVYVMRDGHKGILLGHKGETAKAVSKAAREELVEFLGRKVHLFLQVKVRPNWLEEKERFDEMGLDFRDGNA
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: VWA3B_HUMAN
Sequence: MEKSGPSSTISEQQLQRQEGWINTKTDLAEQSLISSEKWLQLHGLKSNKLTLKQILSQIGFPHCEDYVASLGRPVASRYADGLFPQLYRAEDGRVYNLTAKSELIYQFVEHLTQAVESYKQRMDWLTSKSRQIFGVILEQCVTIVLDFGGILEGELDLCREALTMVLQEQVAHITEFNIIRVSQEPVKWQENATPVTEQSIATAISWVEKLTVELTVSEAGRLDALLEAGRDKTIESIYYFVVGDVPEESKELLLQRALEIPCPVYTVSFNARGEGTIAFLKDLSAKTHSRFHAFAERTECVEFPAFSTKDGDNVMTWNSRKLKGKLPPGAGVREDVFLVWQEMEEACSTLAQIQRLVAEPPKPDVATVDCESETTSVEIASNPEDTWDSKTWLQKYGLKAQKLSLYDVLADCSFRHADGVVDIKAKPENESVQTSAETNKKTVHAKYCSRFVHAPWKDGSLVHVNITKEKCKWYSERIHTALARIRRRIKWLQDGSQSLFGRLHNDCIYILIDTSHSMKSKLDLVKDKIIQFIQEQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDIKIGSSTNTLSALKTAFADKETQAIYLLTDGRPDQPPETVIDQVKRFQEIPIYTISFNYNDEIANRFLKEVAALTGGEFHFYNFGCKDPTPPEAVQNEDLTLLVKEMEQGHSDLEKMQDLYSESLIMDWWYNAEKDGDSKHQKEICSMISTPEKCAKPQSDVDSTQTSSLNMLKGPWGLSDQKVQKKKVLHAESTKTSLLRSQMSSLRSSACSERKDGLSNASSRRTALSDKEMSILLAEEWLDDKSSEKVTREGSQVYDHDSSDVSSENWLKTYGLVAKKLTLMDALSVAAVPHSSTYVPVLDKHVVSKVFDEVFPLAHVCNDTNKMTLINPQGAKLNIYKRKVEQAIQSYEKRLNKIVWRALSQEEKEKLDANKPIQYLENKTVLNQALERLNWPISLKELSMLESEILAGKMYIQQAMELQEAAKKNYANKAPGEQQKLQGNPTKKTKSKRPDPLKGQKVIARCDENGFYFPGVVKKCVSRTQALVGFSYGDTKVVSTSFITPVGGAMPCPLLQVGDYVFAKIVIPKGFDFYVPAIVIALPNKHVATEKFYTVLKCNNRREFCPRSALIKISQNKYALSCSHIKSPPIPEDPEVEDVEARNSAFLFWPLKEADTQDSREPRREKPRRKKRPAKQPLQQAAPSDSDGSSHGISSHGSCQGTHPEPRTAHLHFPAAGRLGLSSHAIIATPPPRAALPCTLQATHSSKGLRSVPETL
What are the official names of this protein?
von Willebrand factor A domain-containing protein 3B, VWA domain-containing protein 3B.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHEA2_HEMAN
Sequence: MYTKIALLGLVGSAAAFNAPMMTVRRDAIATGAAAAVVAPMLRPAGAAMKKDSKAPCVEVFDERDGCKAAGTQKASGDDGFCVKVSMKAIKMNAAEATSVTKNYNTKLL
What is the function of this protein?
Light-harvesting photosynthetic tetrapyrrole chromophore-protein from the phycobiliprotein complex.
What are the official names of this protein?
Phycoerythrin alpha-2 subunit, Phycoerythrin PE555 alpha-2 subunit, PE555A-2.
What is the protein family that this protein belongs to?
Belongs to the phycoerythrin family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side.
Protein: ATPG_BORBR
Sequence: MPGIKEIRTKIKSVQNTRKITKAMEMVAASKMRKAQERMRAGRPYATKVREIAAHLMQANPEYSHPYLVEREVKAVGVVLVTTDKGLCGGLNTNISRVTLSKLKEFEQRSIKVQATAFGNKGLGLLTRIGAKLVSQEVQLGDKPDLDRLLGAIKVQLDDYLEGRIDALYVATTRFVNTMRQEPVFLRLLPLSNGLDDPFQSGVETLAKTAEIKSDYSWDYIYEPDAKSVIDDLLQRYVEGLLYQAVAENMASEQSARMVAMKSASDNAKKVIGDLQLVYNKTRQAAITKEISEIVGGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: XYND_GIBZE
Sequence: MHFLGLVVAFAPAALAQSAIWGQCGGTGWSGSTTCQSGLKCEKINDFYYQCIPGSDNGGGTTPDPGTPSPGNGNADATGLDAKIRAKGKIYFGTEIDHYHLSNNPLINIVKKDFGQVTNENSMKWDAIEPSRGQFTFSNADKVVDFAQANGKKIRGHTLLWYSQLPQWVKNIRDRATMTSVIENHVKTVVTRYKGKILHWDVVNEIFAEDGNMRNSEFYQVLGEDFVGIAFRAARAADPAAKLYINDYNLDIANYAKVTRGMVDHVNKWVSQGIPIDGIGSQAHLAKPGGWNPASGFPAALKVLAGANVKEVAITELDIDGAAANDYVTVVNSCLTTPKCVGITVWGVSDKDSWRSESNPLLFDRNYQPKAAYTAVSNALN
What is the function of this protein?
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.  Plays an important role in causing fusarium head blight (FHB) on cereal crops.
What are the official names of this protein?
Endo-1,4-beta-xylanase D, Xylanase D, 1,4-beta-D-xylan xylanohydrolase D.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MDCG_XANAC
Sequence: MAGRHALVWLREDAQWQAVTSGAQPRLQQWFAAGLPAVVARGDGSQAPGTLRLGVPLPPSEGKQRLALQAHVAGIARCTAPLTLDAVMPHAPLAVQPALQALLAQAHAHALHPHVFGSFAWQALTGLTYVHAQSDLDLLWSIQTPEQACAVLTLVQRWEQQHGLRADGELRLPDDNAVNWREYAGNAQQVLVKSNQDCRLLPRAALFPARSAA
What is the function of this protein?
Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-[acyl-carrier-protein] of the malonate decarboxylase to yield holo-[acyl-carrier-protein].
What are the official names of this protein?
Phosphoribosyl-dephospho-CoA transferase, Malonate decarboxylase holo-[acyl-carrier-protein] synthase, Holo-ACP synthase.
What is the protein family that this protein belongs to?
Belongs to the MdcG family.
Protein: SYH_YERPN
Sequence: MAKNIQAIRGMNDYLPADTAIWQRIESILKQVLSGYGYSEIRMPIVEQTPLFKRAIGEVTDVVEKEMYTFDDRNGESLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRYERPQKGRYRQFHQLGAEVFGLPGPDIDAELILLTARWWRALGIFEHVKLELNSIGSLAARADYREALVAFLEQHVEVLDEDCKRRMYSNPLRVLDSKNPDVQQLLDDAPKLSDYLDEESKQHFAGLCELLDKASIPYTVNERLVRGLDYYNRTVFEWVTHSLGAQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNADFQVPATVDAYVISSGEGAQSAAMLLAESLRDALPTLKIMTNYGGGNVKKQFTRADKWGARVALMLGESEVAAQQVVVKDLRNGEQETLAQADVAARLALMLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_BORRA
Sequence: MAVITMKSLLEAGVHFGHQVKRLDPRMKRFIFSERNEIHILDLQKTLQGIKDSYELVQSVIKNGKKVLFVGTKKQASEIIEQEAKRSEMPYVNNRWLGGMLSNFNTIKKSVQKLKKLEKMEVDGTFEMISKKEVSQINREKLKLAKNLTGIKDMEELPGAIFIIDPKREQIVINEARKLGITIIAVVDTNCNPDVIDCPIPGNDDAIRSVALFTKIISDAILESDKEVGIQIVENLNEEDLMSEIEVKNERKES
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SYM_PYRAE
Sequence: MAKYVIGSAWPYVQTVPHLGNMIGSVLSADVYARYLRLKGHEVVFVSGSDVHGTPVEVEAIQLGVDPAEYSMKMHAIVAELFKKWNISFDLYTHTHSETHIKFVQDFYLKIYENGYIFTKEDEVPYCPRDKIYLPDRFIIGKCPYCGYERARGDQCENCGRLLDPKQLIEPKCAVCGSKPEWRITKHWYLDLRRLEDRIRKYVEENPHLPPNAKEMSLAMLKEGLRPRAVTRDNKWGIPAPFPGAEGKTIYVWFEAVLGYISAVVEYFKKIGREEEWKRFWLDPETKVVFFVGKDNVPFHVIILPALLLANGGGYVMPTTTASTEYLLYEGDKFSKSRRWGVWIDEALQLLPADYWRFVLIYIRPENRDTNFSWSTALEIINKVLNDDVGNYANRVLSFIKNRMGGAVPPRGKPSRDDEEFIEKVKRLFEKAEAHYEAIELKDAVHTVVEIAREGNKYLNARAPWDLVKKDVDAANAVMYHAYWSLKFLAVGLAPAIPESAEQLWKMMGLDAPLTWEEAKRPPAVGKALGEVRPLFRKITEEEVKALLAKLEELRNQKYSRKYPWEQVVI
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_SHIB3
Sequence: MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQGYDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDSELQPSRGQARKTIASNAITINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCLICWK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_CORK4
Sequence: MAIRKYKPTTPGRRQSSVSGFDELTRSTPEKSLLRPLHKTGGRNVHGHITTRHKGGGHKRQYRLIDFRRNDKDGVPAKVAHIEYDPNRTANIALLHYFDGEKRYIIAPRNLKQGTVVESGANADIKVGNNLPLRNIPTGTTIHAVELKPGGGAKLARSAGSSIQLLGKEGKYAILRMPSTEIRRVDARCRATVGEVGNADQINIRWGKAGRMRWKGVRPTVRGVVMNPVDHPHGGGEGKSSGGRHPVSPWGQPEGRTRKPNRPSDGLIVRRRRSNKNKKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: YL583_MIMIV
Sequence: MTSVETILNYLAYFNRGDYVIVLVIKQIIEKYNDKVKELDTLKNQYQNLQQDYENLKQQVSLQRQTMISTTNDIKQIVNDFKENYVNIHPEYISDSQTNCHQVE
What are the official names of this protein?
Uncharacterized protein L583.
Protein: MURD_CHLL2
Sequence: MDVHGKKASIIGAKRSGVAAAELLAKSGAKVFVSELGEPGASEAERLADCGIPWEQDGHTDRVCDADFCVVSPGIPRTAGIIRRVLEQGIPLYSEIEAASWFCKARIAGITGTDGKTTTSTLLHRIAEADGMKNDYRAFSVGNIGVPFSSLVLDMAPADLAVVELSSYQLEGCETFRPDVSVITNITPDHLDRYNGDMQLYAAAKFRIYASQRASDTLVYNFDDPLLRAQFSGNGRGFPFRIVPFGIGNDVPGSGSEEAFFYDEGMIRHLTAKGISEVFSGEDFLKSSFRGRHNIYNALAALAAAAALGIEESVARKAISGFSGVEHRQEFVCSLDGVEWINDSKATNVNALLQALDAVPGSIVLIAGGRDKGNDYTVLFDVVRRKVVTVIAIGEAREKILQVFEGITRTAGADTLDDAVALARESAEKGQTVLFSPGCASFDMFENFEERGRLFKRSILALNPC
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: E2AK1_RABIT
Sequence: MLGGSAGTRGGEAEGDGAGAVGAVAPPPAIDFPAEVSDPKYDESDVPAELQVLKEPLQQPAFPFAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHHNRAITHLMRSARERVRQDPCADNSHIQKIRSREVALEAQTSRYLNEFEELSILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVHVQADRVPIQLPSLEVLSDQEEDRDQYGVKNDASSSSSIIFAEFSPEKEKSSDECAVESQNNKLVNYTTNLVVRDTGEFESSTERQENGSIVERQLLFGHNSDVEEDFTSAEESSEEDLSALRHTEVQYHLMLHIQMQLCELSLWDWIAERNRRSRECVDESACPYVMVSVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACADIIQKNAARTSRNGERAPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSVGVILLELFQPFGTEMERAEVLTGVRAGRIPDSLSKRCPAQAKYVQLLTRRNASQRPSALQLLQSELFQNSAHVNLTLQMKIIEQEREIEELKKQLSLLSQARGVRSDRRDGELPA
What is the function of this protein?
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:3745199).  Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (By similarity).  EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (By similarity).  Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity).  This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity).  Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity).  In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity).  It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity).  Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 2-alpha kinase 1, Heme-controlled repressor, HCR, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Heme-regulated inhibitor, Hemin-sensitive initiation factor 2-alpha kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOL6_ARATH
Sequence: MASSSASATVAVDKATSDLLLGPDWTTNMEICDSVNSLHWQAKDVVKAVKKRLQHKSSRVQLLALTLLETLVKNCGDYLHHQVAEKNILGEMVKIVKKKADMQVRDKILVMVDSWQQAFGGPEGKYPQYYWAYDELRRSGVEFPRRSPDASPIITPPVSHPPLRQPQGGYGVPPAGYGVHQAGYGVPQAGYGIPQAGYGVPQAGYGIPQVGYGMPSGSSRRLDEAMATEVEGLSLSSIESMRDVMDLLGDMLQAVDPSDREAVKDEVIVDLVERCRSNQKKLMQMLTSTGDDELLGRGLDLNDSLQILLAKHDAIASGSPLPVQASGSPLSVQASKPADSSPKSSEAKDSSSIAGSSSPIPATVSTGKSPIDEEYEEEEDEFAQLARRHSKPPASVTTDPTSLESHNAASNALALALPDPPPPVNTTKEQDMIDLLSITLCTPSTPPAPSSQPSPPPPAGSDQNTHIYPQPQPRFDSYVAPWAQQQQPQQPQAQQGYSQHQQHQQQQGYSQPQHSQQQQGYSQLQQPQPQQGYSQSQPQAQVQMQPSTRPQNPYEYPPPPWASTSANAYYTPRANASASYTDTSALAGRSLQQSNSFPTRAGDPQATSTASNSGVSVGQKPFVPSYRLFEDLDVFGSADGKHNKPANSSNGSQNLSGSQTQQSMIGGRKMI
What is the function of this protein?
Acts as a gatekeeper for degradative protein sorting to the vacuole.  Plays a role in recognition of ubiquitinated PIN2 auxin carrier at the plasma membrane and further to its endocytic sorting.  Binds ubiquitin in vitro (PubMed:24316203).  Might contribute to the loading of the ESCRT machinery (Probable).
What are the official names of this protein?
TOM1-like protein 6.
What is the protein family that this protein belongs to?
Belongs to the TOM1 family.
What are the subcellular locations of this protein?
Endosome, multivesicular body. Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Protein: RL19_MYCLE
Sequence: MNRLDFVDQASLRDDIPAFSPGDTINVHVKVIEGVKERIQVFKGVVIRRQGGGIRETFTVRKESYGVGVERTFPVHSPNIDHIEMVIRGDVRRAKLYYLRELRGKKAKIKEKR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: YR825_MIMIV
Sequence: MDCVPLEKWLNTTNMSDIINTLNIIDCIPLEIWLRITNMSGEINLLLTCTKLFGLFEYVNINAPINECEIAIKSIIKYNEISVLKFIINNKFSFRLKYTYFGHMYPPRLMHLSCEKGNLQIVKLLHSIKNNIIQLDSYLIQAVKSKSINVVEYIFNNFGNICQEKINLALLESCRDSWLDGIKYLISKGADINANKCIAFIEAIKTGDLEIIKYFVAQGANYNDHATSIWYWTLHPIKSRVIKYMMSINTQINLDDVYIFHPIIQQEIIELIKYAVSKGYRFDMEKTVHFARILNRSSIIEYLESIINDER
What are the official names of this protein?
Putative ankyrin repeat protein R825.
Protein: GLYA_ALTMD
Sequence: MFSREMNIADFDPELANAMANEVERQEHHIELIASENYCSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEHVDVVEQLAIDRAKELFGADYANVQPHAGSQANSAVFMALLDAGDTVLGMSLSEGGHLTHGSHVNFSGKTYNAVQYGLDKETGEIDYAQVEALAKEHKPKMIIGGFSAYSGIVDWAKFREIADSVGAYLLVDMAHVAGLVAAGVYPNPLPHAHVVTTTTHKTLAGPRSGLILSSCGDEAIYKKLNSSVFPGNQGGPLCHVIAAKAVAFKEALQPEFKAYQQQVVANAKAMVSVMQERGYNIVSGGTDNHLFLLDLIDKDITGKDADAALGAANITVNKNSVPNDPRSPFVTSGLRIGSPAITRRGFKEEQAKQVATWICDILDNMGDESVIKRVQSEVVALCAQFPVYK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBED_ECO5E
Sequence: MKTKLNELLEFPTPFTYKVMGQALPELVDQVVEVVQRHAPGDYTPTVKPSSKGNYHSVSITINATHIEQVETLYEELGKIDIVRMVL
What are the official names of this protein?
UPF0250 protein YbeD.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: PGK_STAAS
Sequence: MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPELGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_BRUA1
Sequence: MDIRAAEISAILKEQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLESDNVGVVIFGADRDIKEGDVVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPIKAKERRRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAIILDTFLNQKPIHDNGPDKDKLYCVYVAVGQKRSTVAQFVKVLEERGALEYSIVVAATASDPAPMQYLAPFAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDENGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETNLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIYAGVNGYLDKLAVNQVGKFEEGLLASLRTEHKDVLEGIRNEKALTDDLKAKLKAAIDAFAKSFV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FDH_SOLTU
Sequence: MAMSRVASTAARAITSPSSLVFTRELQASPGPKKIVGVFYKANEYAEMNPNFLGCAENALGIREWLESKGHQYIVTPDKEGPDCELEKHIPDLHVLISTPFHPAYVTAERIKKAKNLQLLLTAGIGSDHVDLKAAAAAGLTVAEVTGSNTVSVAEDELMRILILVRNFLPGHHQVINGEWNVAAIAHRAYDLEGKTVGTVGAGRIGRLLLQRLKPFNCNLLYHDRLKMDSELENQIGAKFEEDLDKMLSKCDIVVINTPLTEKTKGMFDKERIAKLKKGVLIVNNARGAIMDTQAVVDACNSGHIAGYSGDVWYPQPAPKDHPWRYMPNQAMTPHISGTTIDAQLRYAAGTKDMLDRYFKGEDFPAENYIVKDGELAPQYR
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide (PubMed:8278546).  Involved in the cell stress response.  Involved in formate-dependent oxygen uptake coupled to ATP synthesis (PubMed:9490763).
What are the official names of this protein?
Formate dehydrogenase, mitochondrial, FDH, NAD-dependent formate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
What are the subcellular locations of this protein?
Mitochondrion.