PharMolix/UniProtQA huggingface dataset:
Protein: SERC_LACH4
Sequence: MTVYNFAAGPATLPDPVIKQIQEELPSLQGSGMSILEISHRSQMFDKIIDTAKQDIKDLMHVPDNYHILFFQGGGTGQFAAVPMNLATKHKRIALLDSGHWATRAGDEAANLGVTVDVLDSTKDKHYQELPHMPHAISASDYDYLHITTNNTIEGTAYHTLPEHGDVTLVGDLSSNFMAEEYQVSDFGLIFGGVQKNLGPAGVTVVIVRDDLVNHVDHIPSILNYELFVKKNSMFNTPPVFAIYATGLVLKWLKQQGGIAGIEALNKKKSALLYDFLDQSTLFHNDIKKTDRSLTNIPFKTTDPVLDKQVIAEADQAGLKNLKGHRSVGGLRASLYNAMPLAGVQALVDFLYNFEKQHKNNTMGKRYVSSKNI
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_BORBU
Sequence: MFKVIKCNELNEKLIDKKVEINAWVKKIRHHGKFIFLNIRDRYEKAQVLVNEEKLLKIAEKIKLEYCIKIQGLLIKRPPNMINANMKTGHFEILAKNIEIISKCNELPFMIEDDNNASENSKLEYRYLDLRRDSLKNKIILRCQATHLIRNFLIKRKFLELETPTFVKSTPEGARDFVIPSRIHKGSFYALPQSPQLYKQLIMIAGFDKYFQIARCYRDEDSRGDRQPEFTQLDLEMSFVKKENIFKLIENMLFLIFKNCININLPKKFKKITYKKAMNKYGSDKPDTRFELELQDISRNLKNSEFNIFKDTLKNKGSIKILIVKDKADKFSRAKINNLEEIAKLYKTQGLYFTKIENNKFSGGIAKFLKTEEQELIKTYSLENNDIIFFTANNNWETACKAMGQIRIKIANDLGLIDENKFEFLWVYDFPLFEYDENTKTYSPAHHMFSLPKKQYIANLEKNPKKTIGEIYDLVLNGVELGSGSIRIHNKELQQRIFKIIGFQKEKSEDRFGFFLKALEYGAPNHGGIAIGIDRLIMLMTKSTSIKDVILFPKNSFAASPLDNSPSKISNEQLKELGINIVDGDN
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_HAEI8
Sequence: MKNMEQQHIEVVGKLGSTYGIRGWLRIYSSTEQAESIFDYQPWFLKIKGEWQSIELENWRYHNHEIIVKLKGVDDRETAQILANVEIGVDLSVFPELEEGDYYWHDLIGCTVVNLEGYTMGTVTEMMETGSNDVLVVKANTKDAFGKQERLIPFLYEQVVKRVDLTTKTIEVDWDAGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_COPPD
Sequence: MKIAFFSSGTFGLPVLEELKKENHEIVLITKVDAPSGRGLKLQPSPPAVVAEALQIPIVKVNSLKNDFIEWYFSQGFDVAIVVDFGFYIPKQLFQADKPVMVNIHPSLLPKYRGPNPIRRAICSGELETGVTLIKISEKMDEGDIYLQERVLIDPDDDYVSLTPKLQHVSMELLKKFFLELKQGNLRAFPQLGDPSYAPKFTPDELWIDWQKPAHDIQNQVRALADVGAKTTLGSKLVKIFKVRISGMEDSLPPGHYVAEKESLYVGTGQGSLEILSLQQEGRKKQDAASFVKGLREKEGVFGG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: FLGI_THIDA
Sequence: MKLPHFFVLAALVLSGAAHAERIKDIAAIQGVRANQLFGYGLVVGLDGTGDQTTQTPFTTQSIANMLTQMGVNLPPGINMQLKNVAAVMVTADLPPFAQAGQAIDVTVSSIGNAKSLRGGTLVMAPLKGADGLVYAMAQGSLVVSGAGASANGSKVQVNHLSVGRIPAGATVERTVATALGESGSINLELRQSDFTTASRVVDVVNARFGADTARALNARVVAVKTPLGASERVAFLGAIEGLEVSPGQAMAKVIINARTGSVVMNQTVTLDPSAVSHGNLSVVISTAPVISQPAPFGRGETVVAAESQIEIRQQPGEVMMLKGGASLADVVKALNSIGATPQDLLAILQALKASGALRAELEVI
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: ARFV_ORYSJ
Sequence: MKEVGEVEEVRCLDPQLWHACAGGMVQMPAPRSRVYYFAQGHAEHADGGGGAAAAAAELGPRALPPLVLCRVEGVQFLADRDSDEVYAKIRLAPVAPGEAEFREPDELCPLGAAGDAAEPSPEKPTSFAKTLTQSDANNGGGFSVPRYCAETIFPKLDYRADPPVQTVLAKDVHGVVWKFRHIYRGTPRRHLLTTGWSTFVNQKKLVAGDSIVFLRTRHGELCVGIRRAKRMACGGMECMSGWNAPGYGGGGFSAFLKEEESKLMKGHGGGGYMKGKGKVRMADVVEAASLASSGQPFEVAYYPRASTPDFVVKAASVQAAMRIQWCSGMRFKMAFETEDSSRISWFMGTISSVQVADPNRWPNSPWRLLQVTWDEPDLLQNVKCVSPWLVELVSSIPPIHLGPFSSPRKKLRVPPHPDFPFEGHLLNPIFHGNPLGPSNSPLCCYPDTAPAGIQGARHAQFGLPLTDHQLNKLHLGLLHSGSFNRLDAITPPSRISKGFVVSSAPAHDNISCLLSISTPQVAEKSDDRKTTPHIMLFGKAIFTEQQITSSGSTETLSPGVTGNSSPNGNAHKTGNASDGSGSSICIGFSSQGHEASDLGLEAGHCKVFMESEDVGRTIDLSVFGSYEELYGRLADMFGIEKEEIINHLHFRDAAGVVKHPGEVPFSDFMKAARRLTIIAGDRERIERPLIECLVEQA
What is the function of this protein?
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
What are the official names of this protein?
Auxin response factor 22.
What is the protein family that this protein belongs to?
Belongs to the ARF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HAT_MYCTU
Sequence: MSFGFPTFSQNRFTEQYSGLCPIAPGRGAGLQPCRRDCPVARWLVADHPVFGSDCRCRMMVGVNRVRIGRHELTGA
What is the function of this protein?
Histone acetyltransferase, which by binding to the host chromatin, may manipulate the expression of host genes involved in anti-inflammatory responses to evade clearance and to survive in the intracellular milieu.  Acetylates histone H3 at the 'Lys-9' and 'Lys-14' positions.
What are the official names of this protein?
Histone acetyltransferase, HAT.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus. Note=Colocalizes with the chromatin in the nucleus of infected human macrophages.
Protein: SECM_PECCP
Sequence: MIGILNRWRQFGRRYFWPHLLLGMVAASLGLPTSLNDSQDITSLPNSSSSVSRQNNVSLSLTDLVALKEAHRRSSYSVDYWHQHAIRTVIRHLSFALTTPQTVNAQQADELEPHSLVLLDTLNALLTQDSQYPLVISPRAGRVTFYPQAHHQVGIWLAQIRGIRAGPSLLS
What is the function of this protein?
Regulates secA expression by translational coupling of the secM secA operon.  Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
What are the official names of this protein?
Secretion monitor.
What is the protein family that this protein belongs to?
Belongs to the SecM family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Periplasm. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.
Protein: SYI_CALS4
Sequence: MDYNKTLNLPKTDFPMKANLPVREPEILKKWEEMDIYRRVLEKNKGKEKYILHDGPPYANGDIHIGTAMNKVLKDIVVKYKTMRGYDSPYVPGWDTHGLPIEQQVIKILGVKRHEMNPVEFRKVCKDFAFSQIERQRQQFKRLGVRGDWEKPYLTLDPEYEAKQIEVFGEMAKRGYIYKGLKPVYWCPSCETALAEAEIEYFDETSDSIYVKFRVRDDLGKFKGIVEDLSNVYFVIWTTTTWTIPANLAIALNPEFDYSLTKFGDEVYIIAKDMIEEVRKETGLGDYEILATFKGKELEGMKAVHPIYNRDSIVVLGEHVTLDAGTGCVHTAPGHGEEDFLVGQEYGLEALNPIDEKGYFTDKAPGYEGLYYAEANKVIKEDLRKANALLAEKKITHSYPHCWRCKSPILFRATEQWFASVEGFREEALKAIKEVNWYPAWGEERITNMVRDRKDWCISRQRVWGVPIPIFYCENCGKPLINDETINAVKELFRQKGSDAWFEMSAEEILPEGIKCECGSTKFRKETDIMDVWFDSGSSHAAVLETHPDLKWPAELYLEGSDQHRGWFQSSLLTAVATRGKAPYKNVLTHGFVVDGEGRKMSKSLGNVVDPAEVIQEYGADVLRLWVVSADYTADMRTSPEILKQIAEVYRKIRNTARFLLGNLYDFDPDKDMLPYEELLEIDKWALYRLNRLVKQLTESFDKYEFYDFFHPVHNFCVVDMSSLYLDILKDRLYTYPAKSKERKAAQTTLYIILDTLVKLMAPVLAFTSEEIWWHMKHDRNNNFESVQLADWPQVKEEYDNPYIIEKWEKLFDIRKDISKALEIARSEKKIGHSLDAQVDIYPSSELYEFFKGFEDLQYVFIVSKVVLHDPQEVAPENAYVSEDYDLKITVTRAPGEKCERCWMYSETVGTIKEHPTICARCASHIEEQLKV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DLTC_STRP3
Sequence: MSIEETVIELFDRLFMEDVSEMMDEDLFDAGVLDSLGTVELIVELESTFNIKVPISEFGRDDWNTVTKIVQGVEELQHA
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_HELPY
Sequence: MRHYETMFILKPTLVEEEIKSKIEFYKEVITKHHGVIETSLDMGMRNLAYEIKKHKRGYYYVAYFKAEPSMIVELERLYRINEDVLRFIVIKYESKKEVEAWHALVDRANKKPSHAKEKHEKTEHTHSHHTEEAESVGSHSE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RM06_DICDI
Sequence: MKYSQNKSLNTFEIEYKIANKSVKIKSSGKMGVITKELKLKEPAIQSNNIYYLKNHGDSRIIIGTMKQQIQGVLAGFCIELKLVGLGFVVHKVGNTLVLDVGYSHYRSCLIPKEVVVKLEGSQIILYSINKEKVTTFASLLKTFKKINMYKGTGILGINEKIKLKKGKVR
What are the official names of this protein?
60S ribosomal protein L6, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: OEP24_ORYSI
Sequence: MKATVKGRYEGDKATAAATLAFTPSAADLRFKASATDAAFARGPSLEGLTLTLEKPGSFLLDLKPHSKDVRFQFMNSALLLDRRVSLTYTHSTTLSPGPAKPPARTALDGSLTFDPANKLSLSHTLGSSGCRVKYSYAHGQDRLTTIEPCFDTANNAWDFAVTRKFQGGDAIKATYQASTKLLALDWTRDSKIGASFKVAASFDLSDQSKAPKLIAESTWNYEI
What is the function of this protein?
High-conductance voltage-dependent solute channel with a slight selectivity for cations transporting triosephosphates, dicarboxylic acids, ATP, inorganic phosphate (Pi), sugars, and positively or negatively charged amino acids.
What are the official names of this protein?
Outer envelope pore protein 24, chloroplastic, Chloroplastic outer envelope pore protein of 24 kDa.
What is the protein family that this protein belongs to?
Belongs to the plastid outer envelope porin OEP24 (TC 1.B.28.1) family.
What are the subcellular locations of this protein?
Plastid, etioplast membrane; Multi- pass membrane protein. Plastid, chloroplast outer membrane; Multi-pass membrane protein. Note=Present in non-green root plastids.
Protein: CAPSD_PLRV1
Sequence: MSTVVVKGNVNGGVQQPRMRRRQSLRRRANRVQPVVMVTAPGQPRRRRRRRGGNRRSRRTGVPRGRGSSETFVFTKDNLVGNTQGSFTFGPSLSDCPAFKDGILKAYHEYKITSILLQFVSEASSTSSGSIAYELDPHCKVSSLQSYVNKFQITKGGAKTYQARMINGVEWHDSSEDQCRILWKGNGKSSDSAGSFRVTIKVALQNPK
What is the function of this protein?
Major capsid protein that self-assembles to form an icosahedral capsid with a T=3 symmetry, about 23 nm in diameter, and consisting of 180 capsid proteins monomers (PubMed:31611039, PubMed:34813955).  Most of the 180 monomers are the major capsid protein, but a small percentage contain the minor capsid protein, which has a long C-terminal extension (PubMed:31611039).
What are the official names of this protein?
Major capsid protein, Coat protein, CP, P3.
What is the protein family that this protein belongs to?
Belongs to the luteoviruses capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: PROF3_CORAV
Sequence: MSWQAYVDEHLMCDIDGQGQQLAASAIVGHDGSVWAQSSSFPQLKPEEITGIMKDFDEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVFGIYEEPVTPGQCNMVVERLGDYLVEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-3, Allergen Cor a 2, Pollen allergen Cor a 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ATX5_ARATH
Sequence: MIIKRKLKTLKRCNSTNEEDDIVRKKRKVNLNGGGSGGDYYYPLNLLGEIGAGIVPGKNGFSVSLCKQVSCSPKVEVVEEEEEEEEIKSTRLVSRPPLVKTSRGRVQVLPSRFNDSVIENWRKDNKSSGEEREEEIEEEACRKEKVKVSSNHSLKIKQQETKFTPRNYKYSSSSALCGEIDDEDKCEEIVRYGNSFEMKKQRYVDDEPRPKKEGVYGPEDFYSGDLVWGKSGRNEPFWPAIVIDPMTQAPELVLRSCIPDAACVMFFGHSGTENERDYAWVRRGMIFPFVDYVERLQEQSELRGCNPRDFQMALEEALLADQGFTEKLMQDIHMAAGNQTFDDSVYRWVEEAAGSSQYLDHVAPSQDMKKYRNPRACVGCGMVLSFKMAQKMKALIPGDQLLCQPCSKLTKPKHVCGICKRIWNHLDSQSWVRCDGCKVWIHSACDQISHKHFKDLGETDYYCPTCRTKFDFELSDSEKPDSKSKLGKNNAPMVLPDKVIVVCSGVEGIYFPSLHLVVCKCGSCGPERKALSEWERHTGSKAKNWRTSVKVKSSKLPLEEWMMKLAEFHANATAAKPPKRPSIKQRKQRLLSFLREKYEPVNVKWTTERCAVCRWVEDWDYNKIIICNRCQIAVHQECYGTRNVRDFTSWVCKACETPEIKRECCLCPVKGGALKPTDVETLWVHVTCAWFQPEVCFASEEKMEPALGILSIPSSNFVKICVICKQIHGSCTQCCKCSTYYHAMCASRAGYRMELHCLEKNGRQITKMVSYCSYHRAPNPDTVLIIQTPSGVFSAKSLVQNKKKSGTRLILANREEIEESAAEDTIPIDPFSSARCRLYKRTVNSKKRTKEEGIPHYTGGLRHHPSAAIQTLNAFRHVAEEPKSFSSFRERLHHLQRTEMERVCFGRSGIHGWGLFARRNIQEGEMVLEYRGEQVRGIIADLREARYRREGKDCYLFKISEEVVVDATEKGNIARLINHSCMPNCYARIMSVGDDESRIVLIAKTTVASCEELTYDYLFDPDEPDEFKVPCLCKSPNCRKFMN
What is the function of this protein?
Histone methyltransferase.
What are the official names of this protein?
Histone-lysine N-methyltransferase ATX5, Protein SET DOMAIN GROUP 29, Trithorax-homolog protein 5, TRX-homolog protein 5.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SAT_ALLVD
Sequence: MIKPVGSDELRPRFVYDPEQHHRLSSEAESLPSVIVSSQAAGNAVMLGAGYFSPLDGFMNLADALSSAQSMTLTDGRFFPVPLLCLLESADAIAGATRIALRDPNVEGNPVLAVMDVTAVEQVSDAQMALMTEQVYGTSDPKHPGVETFNSQGRTAISGPIQVLNFSYFQTDFPDTFRTAVEIRHEIQERGWQKIVAFQTRNPMHRAHEELCKMAMEAVEADGVVIHMLLGQLKPGDIPAPVRDAAIRTMAELYFPPNTVMVTGYGFDMLYAGPREAVLHAYFRQNMGATHFIIGRDHAGVGDYYGPFDAQTIFDDAVPTDVLAIEIFRADNTAYSKKLGRVVMMRDAPDHTPDDFIQLSGTRVREMLGQGEAPPPEFSRPEVAQILMDYYRSLPQS
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
Protein: SNX5_BOVIN
Sequence: MAAVPEVLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFSGVKEVDDFFEQEKTFLINYYNRIKDSCAKADRMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVESRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSRDVKLAEAHQQECCQKFEQLSESAKDELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
What is the function of this protein?
Involved in several stages of intracellular trafficking.  Interacts with membranes containing phosphatidylinositol lipids.  Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC).  Does not have in vitro vesicle-to-membrane remodeling activity.  Involved in retrograde transport of lysosomal enzyme receptor IGF2R.  May function as link between endosomal transport vesicles and dynactin.  Plays a role in the internalization of EGFR after EGF stimulation.  Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent.  Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation.  Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation.  Plays a role in macropinocytosis (By similarity).
What are the official names of this protein?
Sorting nexin-5.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Endosome. Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2). Detected on macropinosomes. Targeted to membrane ruffles in response to EGFR stimulation (By similarity).
Protein: BGLH_ASPOR
Sequence: MALEIDYVLSHISQEDKIALLAGIDFWHTHPIPELNVPSIRSTDGPNGIRGTKFFAGVPAACLPCGTALASTWDQNLLREVGVLIGKECLAKGAHCWLGPTINMPRSPLGGRGFESFAEDPHLAGAMAASMITGCESTGVISAVKHFVGNDQEHERRAVDVLVTQRALREIYLRPFQIVARDAGPGALMTSYNKINGKHVVESKEMLDMVRQEWKWNPLIMSDWLGTYTTIDSMNAGLDLEMPGPSRYRGRYVESALQARLIKESTIDSRARKVLEFVQQASRAPVSAVETGRDYPEDRALNRNLCANSIVLLKNQNDILPLPKTIKKIALVGSHVRTPAISGGGSASLEPYYTVSLYDAVSEALPHTEILYEVGAYAHKMLPVIDRLLTNAVMHFYNEPVGTERILRATQPMSKTAFQLMDFNAPELNRGLFYATLTGDFTPDVSGVWDFGLTVFGTGLLYVDDELVVDNTTHQTRGTAFFGKGTVQELGSKTLNAGQTYKIRIEYGSANTSPMKAIGVVHFGGGAAHLGACLHVDSAEMVRSAVKAAAEADYTILCTGLNHEWESEGFDRSHMDLPPGIDALITSVLDVAANKTVIVNQSGTPVTMPWADRARGIVQAWYGGNETGHGIADVIFGDVNPSGKLPLSWPVDVKHNPAYLNYASVGGRVLYGEDVYVGYRYYEKVGREVLFPFGHGLSYTTFTVSPDVVFSQEVFRPEEPPTAAVKIKNTGKVAGAQVLQLYISAPHSPTPRPTKELHGFTKVLLQPGEERVAHIRMDKYATNFWDEIEGMWKSEEGIYEALIGTSSQNILAKGTFRVDRTRYWLGL
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase H, Beta-D-glucoside glucohydrolase H, Cellobiase H, Gentiobiase H.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDUB9_MOUSE
Sequence: MAFCAPPAYLTHQQKVLRLYKRALRHLESWCIHRDKYRYFACLMRARFEEHKNEKDMMRATQLLREAEEEFWQNQHPQPYIFPDSPGGTSFERYECYKVPEWCLDYWHPSEKAMYPDYFSKREQWKKLRMESWDREVKQLQEETSPDGIMTEALPPARREGDLPPLWWHIVTRPRERPT
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9, Complex I-B22, CI-B22, NADH-ubiquinone oxidoreductase B22 subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: HISZ_NITEC
Sequence: MRNWLLPEYIEDVLPRDAYRIEKIRRLVMDKLFVHGYQFVMPPLLEYVESLLAGSGSGMNLRMFKVVDQLSGRMMGLRADMTPQAARIDAHLLNTNGVTRLCYASSVVHTVPDEITRTREPFQVGAELYGHSGIESDLEIQRLLLECLSVSGIQSIHLDLGHIRVFRSLIYGSGIRPEFEMELYAALWAKDTSALRELVYTGLNDLDKTVREALLLLPELYGDETVLLRARKYLPNFPEIREALDQLEHVAKALEPYVDRIIFDLADLRGYHYHTGMVFAAYTQGSPVAIALGGRYDEIGKSFGRARPATGFSLDLKQLSRLTDINDYPRGILAPWKPQDDELAAMIKQLRIAGHIVVTELPGENSKEVARCDRNLVLRNGKWEICPVSG
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPA_THEMA
Sequence: MRIILASSSPRRRQLMELLGIEFEVEKPDVEEEFLESPEETVRELSLRKAEWVFKKRKEEEILVIGSDTVVVLDGNILGKPESLEEAKGMLKKLSGKWHVVYTGVAFVSSETKDVIVSSTKVRFRELPESVIDYYVEKYRPLDKAGAYGIQDFAAVFVEKIEGDFFTVVGFPLGMVWQYLYEKGWWKVASKREDDKGGARVAFG
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSAA_STAEQ
Sequence: MSIYDIAVENYDGSTYLLKRYKGKVLIIVNTATNCTLNDQFNKLEMLYKKYHKYGLEILSFPCNDFNNQEPGLIKDIYRVYKYKFGITFPIHAKINVNGEHEHPLYTLLKCKQPGLFGSQIKWNFTKFVVDQQGNIVKRFLPCDNPNQMEKLIRQLLK
What are the official names of this protein?
Glutathione peroxidase homolog BsaA.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
Protein: PAX_I72A2
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEICFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKADYTLDDESRARIKTRLFTIRQEMANRGLWDSFVSPKEAKKQLKKDLKSQELCAGLPTKVSRRTSPALRILEPMWMDSNRTAALRASFLKCPKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: RL11_CHLPD
Sequence: MAKKIIGFIKLQIPAGAANPAPPVGPALGQKGVNIMEFCKQFNAKTQAEAGMITPVVITVYSDKSFTFITKTPPAAVLLLKEAQLKKGSGEPNRNKVGTVSREQVRRIAELKMPDLNAVDVAGAEQMVMGTARSMGIVVEN
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.