PharMolix/UniProtQA huggingface dataset:
Protein: LPXK_NEIMA
Sequence: MPNCFKFHTVIERHWQKPYPVLSFLLKPLSGLFAKIAAKRRTDFLSGKRQSEKLPVPVVVVGNIHAGGTGKTPIVAALVSGLQEKGVKVGIISRGYGRKSKAVHVLNAESRAEDAGDEPLLLFRKTGAPTAVGSSRAEAGRALLAAHPDIGLIVADDGLQHYALRRDVEIAVFPAADTGRTDLDLLPNGNLREPLLRLDSVDAVVVSGGKADALFRPSENMFHSRIEAGRIYRLNNPSEILDTGRLKNQTVVAVAGIAKPARFFDSLRNMGITVKRTVALPDHADISAADLPDADAVIITEKDAVKFSDGICTDNVWVLPVCAIIEPDLAAFVLERLEDVPKAV
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: RLMH_PHOPR
Sequence: MKLQLIAVGTKMPKWVEEGYKEYSRRFPKDMPLELIEIPAGKRGKNADIARILQKEGEAMLATVAKGNRIVTLDIPGKRWDTGQLAQQLDSWKLDGRDVSILIGGPEGLSPACKAAAEQSWSLSPLTLPHPLVRVVMAESLYRAWSVTANHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAPC1_HUMAN
Sequence: MGSQGSGGVPLVQAPYTVLLLPLGTSRQDPGAQSFFLWLRRMQALEREQDALWQGLELLQHGQAWFEDHLREAQRQQLHLGALGENFLTDLHSEPGRPPLAQIQKVNICLQNLIHEKELSRQQKGVTQPKEEMAQRGCTKGPRGPTRV
What are the official names of this protein?
Suppressor APC domain-containing protein 1, Protein G7d.
Protein: DEOC_STAEQ
Sequence: MNKAKLIDHTLLKTDSTKEQIDTIINEAKAYQFKSVCVNPTHVQYASEQLKGTDVLVCTVIGFPLGATTTAVKSYETKDAINNGAQEIDMVINIGALKDGRFDKVQNDIEAVVQAANGKTVKVIIETVLLTEKEKIKACQLSEAAGAHFVKTSTGFAGGGATVEDVKLMKDTVGDRLEVKASGGVRNLEDFNNMIEAGATRIGASAGVQIIQGLESNTDY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCY2B_ARATH
Sequence: MSINMKTFTQALARTAAVIEKTVHTTVQEVTGPKALQDYELLDQIGSAGPGLAWKLYAAKARDSTRPQQYPTVCVWMLDKRALSEARVRANLSKAAEDAFLDLIRADAGKLVRLRHPGVVHVVQALDENKNAMALVTEPLFASVANALGNVENVGNVPKDLKSMEMSLLEVKHGLLQISETLNFLHNNANLIHRAISPENVLITSAGSWKLAGFGFAISAAQAGNLDNMQSFHYSEYDVEDSILPVQPSLNYTAPELMRSKSPSAGASSDIFSFGCLAYHLVARKPLFDCNNNVKMYMNTLNYITNESFSSIPSELVSDLQRMLSTNESFRPTALDFTGSNFFRSDARLRALRFLDHLLERDNMQKSEFLKALSDMWKDFDSRVLRYKVLPPLCAELRNLVLQPIILPMVLTIAQSQDRTDFELITLPALVPVLSTASGDTLLLLVKHADLITNKTDSEHLVSHVLPLLLRAYNDNDVRIQEEVLKRSTSVAKQLDGQVVRQAILPRVHGLALKTTVAAVRVNALLCLAELVQTLDKPAAIEILETIQRCTAVDRSAPTLMCTLAVANAILKQYGVEFTAEHVLTLMMPLLTAQQLNVQQFAKYMLFVKDILRKIEEKRGVTVNDSGVPEVKPHSAANGLQFQSSTQIPEKVASAAKSSPAWDEDWGSPSKDSAVGNPASSRHNTNDQFNKSTDQSQPSIMSTLPNKTTAPTTCPAVDIEWPPRQSSSLTAPATDNQTQLNTGTSFASGFDELDPFANWPPRPNNGASVASTGLKNGAASNFSNNLPGGTHFQTANNDNWAFSSASLSSLKPPQQGNQGISANNQDPLNSFGVPKQSQGMPSFTSGSYNNQKPADISSIFGSSKTEPSAMKLAPPPSIAMGRGRGRGRGGTGTSTSKPSGSQPSLLDLL
What is the function of this protein?
Probably inactive kinase (PubMed:28751315).  Component of the AP2-containing clathrin coat that regulates clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (PubMed:28751315).  Together with SCYL2B, required for cell growth, plant growth and development (PubMed:28751315).  Essential for polarized root hair development probably by mediating the root hair tip localization of cellulose synthase-like D3 (CSLD3) (PubMed:28751315).
What are the official names of this protein?
SCY1-like protein 2 B, Inactive protein kinase SCYL2B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Prevacuolar compartment membrane. Note=Colocalizes with the clathrin heavy chain 1 (CHC1).
Protein: RS20_BURP0
Sequence: MANSAQARKRARQAAKANSHNSALRSKFRTAIKAVRKAIDAGDQAKAAELFKAATKTIDTIADKKIVHKNKAARHKSRLSAAVKGLQAQAAQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: PYGL_SHEEP
Sequence: MAKPLTDQEKRRQISIRGIVGVENVAELKKGFNRHLHFTLVKDRNVATPRDYFFALAHTVRDHLVGRWIRTQQYYYEKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQIEEADDWLRHGNPWEKARPEFMLPVHFYGRVEHTEAGTKWIDTQVVLALPYDTPVPGYLNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDVIRRFKASKFDSSNSAETAFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWEITQKTFAYTNHTVLPEALERWPVELVENLLPRHLQIIYEINQKHLDKIAALFPKDVDRLRRMSLIEEEGVKRINMAHLCIVGSHAVNGVAKIHSDIVKTQVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLNSFLGDDIFLREISNVKQENKLKFSQFLEKEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVVTMYNRIKKDPKKLFVPRTVIIGGKAAPGYYMAKLIIKLITSVAEVVNNDPMVGSKLKLIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMQNGALTIGTMDGANVEMAEEAGEENLFIFGMRVEDVAALDKKGYEAKEYYEALPELKLAIDQIDKGFFSPKQPDLFKDLVNMLFYHDRFKVFADYEAYVKCQEKVSQLYMNPKAWNIMVLKNIAASGKFSSDRTIKEYARDIWNMEPSDIKISLSGEPSGGANKANGK
What is the function of this protein?
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
What are the official names of this protein?
Glycogen phosphorylase, liver form.
What is the protein family that this protein belongs to?
Belongs to the glycogen phosphorylase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: IOLA2_BACCZ
Sequence: MTVQTAPQIVKNYIGGEWVESISTKMEAVYNPATGEVIAQVPLSTKVDVEQAVSAANEAFKSWSKTAVPKRARILFKYQQLLVDNWEELAKLITIENGKSYNEAYGEVLRGIECVEFAAGAPTLMMGKQLPDIATGIESGMYRYPIGVIGGITPFNFPMMVPCWMFPLAIACGNTFVLKPSERTPLLAARLAELAEEAGLPKGVLNIVNGAHDVVNGLLEHKLVKAISFVGSQPVAEYVYKKGTENLKRVQALAGAKNHSIVLNDANLELATKQIISAAFGSAGERCMAASVVTVEEEIADQLVGRLVEEANKIVIGNGLDEDVFLGPVIRDNHKERTIGYIDSGVEQGATLVRDGREDTAVKGAGYFVGPTIFDHVTKEMKIWQDEIFAPVLSIVRVKSLDEAIEIANESRFANGACIYTDSGASVRQFRETIESGMLGVNVGVPAPMAFFPFSGWKDSFYGDLHANGTDGVEFYTRKKMLTSRWEK
What is the function of this protein?
Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.
What are the official names of this protein?
Malonate-semialdehyde dehydrogenase 2, MSA dehydrogenase 2, Methylmalonate-semialdehyde dehydrogenase 2, MMSA dehydrogenase 2, MSDH 2.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. IolA subfamily.
Protein: WECG_ECOSE
Sequence: MNNNTTAPTYTLRGLQLIGWRDMQHALDYLFADGQLKQGTLVAINAEKMLTIEDNAEVRELINAAEFKYADGISVVRSVRKKYPQAQVSRVAGADLWEELMARAGKEGTPVFLVGGKPEVLAQTEAKLRNQWNVNIVGSQDGYFKPEQRQALFERIHASGAQIVTVAMGSPKQEIFMRDCRLVHPDALYMGVGGTYDVFTGHVKRAPKIWQTLGLEWLYRLLSQPSRIKRQLRLLRYLRWHYTGNL
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: ZDS_SOLLC
Sequence: MATSSAYLSCPATSATGKKHVFPNGSPGFLVFGGTRLSNRLVTRKSVIRADLDSMVSDMSTNAPKGLFPPEPEHYRGPKLKVAIIGAGLAGMSTAVELLDQGHEVDIYESRTFIGGKVGSFVDRRGNHIEMGLHVFFGCYNNLFRLLKKVGAEKNLLVKEHTHTFVNKGGEIGELDFRFPVGAPLHGINAFLSTNQLKIYDKARNAVALALSPVVRALVDPDGALQQIRDLDNVSFSEWFLSKGGTRASIQRMWDPVAYALGFIDCDNMSARCMLTIFALFATKTEASLLRMLKGSPDVYLSGPIKKYIMDKGGRFHLRWGCREVLYETSSDGSMYVSGLAMSKATQKKIVKADAYVAACDVPGIKRLVPQKWRELEFFDNIYKLVGVPVVTVQLRYNGWVTELQDLERSRQLKRAAGLDNLLYTPDADFSCFADLALASPDDYYIEGQGSLLQCVLTPGDPYMPLSNDEIIKRVTKQVLALFPSSQGLEVTWSSVLKIGQSLYREGPGKDPFRPDQKTPVENFFLAGSYTKQDYIDSMEGATLSGRQASAYICNVGEQLMALRKKITAAELNDISKGVSLSDELSLV
What is the function of this protein?
Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene.  It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'.
What are the official names of this protein?
Zeta-carotene desaturase, chloroplastic/chromoplastic, 9,9'-di-cis-zeta-carotene desaturase, Carotene 7,8-desaturase.
What is the protein family that this protein belongs to?
Belongs to the zeta carotene desaturase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, chromoplast.
Protein: RLMD_PHOAS
Sequence: QLNMALMLFLAPSSDELDHVLGEQPYYDIDDVRLTFSPKDFIQVNRDVNVKMVEQAINWLDIQPQDRVLDLFCGLGNFSLPLARRAKAVVGVEGVDEMVARATANAAANGLDNATFYQANLDEDVTKLVWAQEQFDKILLDPARAGAAGVMQHIVNLAPSKVVYVSCNPATLARDSQMLLQQGYKLARLGMMDMFPHTGHLESMTLFVKTNHHKKNSNVM
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: RL34_NOSS1
Sequence: MQRTLGGTNRKRKRTSGFRARMRTPDGRNVIRARRKRGRHRLSV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: YLF2_CAEEL
Sequence: MIICASRVSHLALQKFRNQIPTMKLHKVRTVNCSADYPDVECNGYTAYDTAQKVIVISFRGTKGPNQNNQIVEGMTRDGLLPYFGNGSGKIFKVLYDSFMLLWNEWYSNKFPSSFHIIHRLDLIPRVPAIDPHTNTTVMFHPRTEVWYNNYMRLNDTYQICEEADGNNCSDAVTEGLNMNDHGFYFDINIANWGKDGCPKNTTGYSQP
What are the official names of this protein?
Uncharacterized protein C40H1.2.
Protein: Y4ZD_SINFN
Sequence: MHGGIQRISLRGSMLMPPQSNWQDNRFSSVAAQVDVPRAHIRGHARFSI
What are the official names of this protein?
Uncharacterized protein y4zD.
Protein: TOLB_PSE14
Sequence: MINLFRGLLVVLCFASAMVSAEEKNILVTSGSDRAAPIAVVPFGWQGGNVLPEDMAEIVSNDLRNSGYYAPIPKQNMISLPTQASEVIFRDWKALGAQYVMVGNITPAGGRLQIQYALFNVATEQQVLTGNVSGTNDQLRDMAHYIADQSFEKLTGIKGAFSTRMLYVTAERFSENNTRYTLQRSDYDGARAVTLLQSREPILSPRFAPDGKRIAYVSFEQKRPRIFVQHIDTGRREQITNFEGLNGAPAWSPDGSKLAFVLSKDGNPEIYVINLASRQLSRVTNDSSIDTEPFFGKDGSTLYFTSDRGGKPQIYKTNINGGGAERVSFVGNYNANPKLSADEKTLVMIHRQDGFTNFKVAVQDLARGSVKILTDSNLDESPTVAPNGTMVIYATRQQGRGVLMLVSINGRVRLPLPTAQGEVREPSWSPYLN
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DAPH_STRP2
Sequence: MTATKMNAQEIIQFIANAEKKTSVKVTFEGQLATAVPSSVVKLGNVLFGDWKDVAPLLEGLVENQDYVVEQDARNSAVPLLDKRAINARIEPGAIIRDQVEIGDNAVIMMGAVINIGAEIGAGTMIDMGAILGGRAIVGKNSHVGAGAVLAGVIEPASAEPVRVGDNVLIGANAVVIEGVQIGSGSVVAAGAIVTQDVPENVVVAGVPARIIKEIDAQTQQKTALEDALRTL
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: MURD_FRATT
Sequence: MFSFYFNDNKITKLLMVGYGSTGKSVCDFLANFIDITVDISQNDDEFVNYDLNSYDLITVSPGIPLNKSPYRALTKFKDKIVSDIDIFYQYIKDTKAKTIAVTGSNGKSTVVTMTDFVLKDLGYKSILVGNIGTPALNKIGEKFDYCVVEVSSFQINLFNCVRFDLGCIINVSPDHLDRYQNFEQYKQSKLNLAKFSNDFFVYDVHNGIKYAGEYQIIRGAIYRNSTKLLDIVETKLFGEHNLENIIVVLNILDRLGLDINQAIDSIKKFKGLEHRCKIVKKVNSTTYINDSKGTNVGATIAALNSITNSKNIILLLGGVAKGGDFSLMIKSLDKYVKYVYIYGADKEYIESYIKGYCKYQLCNNMKQAFELSSQKANSNEIVLLSPACASFDEFSGYAQRGEVFQNLVAQLEQKS
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_STRP3
Sequence: MRIADYSVTKAVLDRHGFTFKKSFGQNFLTDTNILQKIVDTAEIDQNVNVIEIGPGIGALTEFLAENAAEVMAFEIDDRLVPILADTLRDFDNVQVVNQDILKADLQTQIKQFKNPDLPIKVVANLPYYITTPILMHLIESKIPFQEFVVMMQREVADRISAEPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMMRRDQPLIEVKDEDFFFRVSRLSFVHRRKTLWNNLTSHFGKSEDIKAKLEKGLALADIKSSIRGEALSIQDFGKLADALKEVGL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP1_LAGHI
Sequence: MARYRHSRSRSRSGYRRQRRRRSRYRSRRRRYRRRQRRSRRGRRRGYSRRRYSRRRYSRRRRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RR19_PHAAN
Sequence: MTRSLKKNPFVANHLLRKINKLNTKAEKDIILTWSRASTIIPTMIGHTIAIHNGKEHLPIYITDRMVGHKLGEFSPTLNFRGHAKNDNRSRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PLSX_SHESH
Sequence: MTNLTLALDAMGGDYGPRITVPAALQALRLYSFLNFYLVGNKTDIEKYLSQVESDVLRRIEIIHTTEVVTMSDRPAHALRNRKQSSMRLAIELVRDGKAQACLSAGNTGALMAMSKVLLKTLPGIDRPALVSCLPAVNKTPVYLLDLGANVSCCSETLFQFAVMGSVLCEAVDKNCSPKVALLNVGIEEIKGNDQVQQAGQLLQQSPQINYTGFIEGNDLFSGRVDVIVCDGFVGNITLKTSEGIARLLVHQLEKGLTKGFFVRLMAKMIAPRINSVLNQMNPDHYNGASLIGLRGIVVKSHGSADESAYLQAISLAVTEAQRRLPQMIEERLESILLDINN
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ILVD_NITWN
Sequence: MPAYRSRTSTHGRNMAGARGLWRATGMKNEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFHTIAVDDGIAMGHDGMLYSLPSREVIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPSVFVSGGPMESGKVTLNGKVKSVDLIDAMVAAADDSVSDADVEAIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSVLATHADRKGLFVEAGHLIVDMARRYYEQNDERVLPRSVASFKAFENAMTLDISMGGSTNTVLHLLAAAYEGEVPFTMADIDRLSRRVPVLCKVAPSVADVHLEDVHRAGGIMGILGELDRAGLIDASLPTVHSNSLREALERWDIKRTKSESVRTFYTAAPGGVRTEIAFSQDKRFEELDADRAKGCIRDAEHAFSKDGGLAVLYGNIARDGCIVKTAGVDDSILTFSGPARVFESQDAAVDAILGNRIKPGDVVLIRYEGPRGGPGMQEMLYPTSYLKSKGLGKQCALITDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEEGDLIAFDIPNRKVHLDVSDAELERRRAAMEAKGDKAWKPAAPRTRRITMALKAYAAHTTSAALGAVRVVKD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: GRHL1_PONAB
Sequence: MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRSSTAKPEVEHPEPDHSKRNSIPIVTEQPLISAGENRVQVLKNVPFNIVLPHGNQLGIDKRGHLTVPDTTVTVSIATMPTHSIKTETQPHGFTVGIPPAVYHPEPTERVVVFDRNLSTDQFSSGAQAPNAQRRTPDSTFSETFKEGVQEVFFPSDLSLRMPGMNSEDYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSNEGIHHPISKVRSVTMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQIDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVPLLPSHKRMDITVFKPFIDLDTQPVLFIPDVHFASLQRGTHVLPIASEELEGEGSVLKRGPYSTEDDFAVPPSAKLARIEEPKRVLLYVRKESEEVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQIEEAGGSYKLTLIEI
What is the function of this protein?
Transcription factor involved in epithelial development.  Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (By similarity).  Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier.  There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity).  May play a role in regulating glucose homeostasis and insulin signaling (By similarity).
What are the official names of this protein?
Grainyhead-like protein 1 homolog, Transcription factor CP2-like 2.
What is the protein family that this protein belongs to?
Belongs to the grh/CP2 family. Grainyhead subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ASPA_PARMW
Sequence: MTRCDVLVVGGTHGNEINGAWLVDQWRDQHDLLDAAGLSLALEIGNPEARTANRRYVDRDLNRCFTADLLNQGGQEQELQRARQLLAWHGPDGATPCRVALDLHSTTAAMGSCLVVYGRRPADLALAARVQGALGLPIYLHEADAAQTGFLVEQWPCGLVIEVGPVPQGVLDALVVRQTRIALETCCQELAAARAGTGRDPHNLVVHRHLGSVDLPRDQRDCAAAMVHPQLQGQDWRPLMDGAAMFELPRGGTVPLQADEGETWPLFINEAAYAEKRIAFSLTRREVWPIDPSWGQALEQLMG
What are the official names of this protein?
Probable aspartoacylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Protein: PSB28_THEVB
Sequence: MGAMAEIQFIRGINEEVVPDVRLTRARDGSSGQAMFYFDNPKIVQEGNLEVTGMYMVDEEGEIVTRDVNAKFINGQPVAIEATYTMRSPQEWDRFIRFMDRYAASHGLGFQKSENS
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LTX2A_NEOCU
Sequence: FVKELWDKVKKMGSAAWSAAKGAFA
What is the function of this protein?
Membrane-perturbating peptide with multiple activities (PubMed:34302796).  It is insecticidal, since it induces reversible paralysis in insects (L. cuprina) after 1 hour, but fails to kill them (PubMed:34302796).  It shows moderate antibacterial activity against some Gram-positive and Gram-negative bacteria (PubMed:34302796).  It is also antiparasitic, since it moderately inhibits the larval development of the major pathogenic nematode of ruminants (H. contortus, IC(50)=23. 2 uM), but fails to reduce the motility of adult males of the other nematode B. malayi (PubMed:34302796).  It also shows moderate cytotoxic activity against HEK293 cells (EC(50)=48-57 uM) but does not induce hemolysis in human erythrocytes (PubMed:34302796).  It also causes a moderate increase in intracellular calcium concentration on neuronal and epithelial cell lines, which supports a non-specific membrane perturbation mechanism of action (PubMed:34302796).
What are the official names of this protein?
M-poneritoxin-Nc2a, M-PONTX-Nc2a, Poneratoxin, Ponericin Nc2a.
What is the protein family that this protein belongs to?
Belongs to the ponericin-L family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Adopts an alpha- helical conformation in membrane-mimetic environments.
Protein: NUSB_YERPP
Sequence: MKPAARRRARECAVQALYSWQLSKNDIADVELQFLSEQDVKDVDIAYFRELLSGVAVNAASLDALMAPFLSRQLEELGQVERAVLRIALFELSKRDDVPYKVAINEAIELAKTFGAEDSHKFVNGVLDKVAPTVRKRK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RL7_ACHLI
Sequence: MAKLTKQAFVEALKEMSLLEIKELVDGLKEEFGIDPSAVAVAAGPAAAAEVEEKTEFNVVLKSFGDKKIEVIKVTREVTGLGLVEAKKLVETADAVIKENAKKDEAEALKAKFEAAGAVVEIV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: PDXA_STRM5
Sequence: MRPELALVPGEPAGIGPELCVRLVQQPREDCRLLAFADPDTLRAAAAALNLPLQLLPEDAEARVPGDLRVRAVPNAVPSHFGHADPANAGAVIGALLGAGQACLSGELHGVVTGPVHKAVINEGGIAYSGTTELLADQAGVKVVMMLANHIVRVALATTHLPLRDVADAITAPGLEHTLRTVHAALRREFGLAAPRIAVLGLNPHAGEDGHLGREELDLVIPLLQRLRAEGMDLVGPLPADTAFLPAKLAGFDTVLAMYHDQGLPVLKYSGFEQAVNLTLGLPYPRVAVDHGTALDLAGRGIADPSSLQAATTLCAQLARQRTLSA
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_GLOVI
Sequence: MIALYPGSFDPLTYGHLDIIERAARLFDRVVVAVLRNPAKVPLFTVEERLSQIQKAVRHLDNVEVEAFHGLTVTVARRLDARVLLRGLRAVSDFEAELQMAQTNRTLATEIETLFLSTSTEHSFLSSSLVKNIAAAGGPVSHMVPEHIEKELRTRFAGAPL
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.