PharMolix/UniProtQA huggingface dataset:
Protein: RR4_CHAVU
Sequence: MSRYRGPRLKIVRRLGPLPGFTQKLYKSKSQYLGSSTTSSSSNKKISQYNIRLLEKQKLRFYYGLTERQLLKYVTIARNAKGPTGQVLLQLLEMRLDNIVFRLGMAPTIPAARQLVNHRHILVNDFTVNIPSYSCKLGDKISVQKRFESKTNIFANSTQSASLKVPSHLTLNPAKNEGLVHQIVDREFIGAKINELLVVEYYSRQV
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LIPA_GEOUR
Sequence: MKITRRPEWLQKKISPSAHAEMERLLGDLQLHTVCQEAHCPNISECFRSRQATFLILGNICTRLCSFCNVTKQSPHHFDPDEPARVAAAVQKLQLSHVVITSPTRDDLPDGGAGLYAQTVTAIRKAAPQTAIELLIPDFMGDHGSIAAVVAACPDISGHNLETVPRLYHIRSGADYRRSLDVLKIIHDLDPRLLTKSGLMLGLGETEVEIFQVLDDLLAVGCSYLSLGQYLAPSRSHYPVQGYVPPEIFDNYRERALAMGFKHVESGPYVRSSYHAEQYGMKG
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE6_PCPV1
Sequence: MEKANASTSAKTIDQLCKECNLCMHSLQILCVFCRKTLSTAEVYAFQYKDLNIVWQGNFPFAACACCLEIQGKVNQYRHFDFAAYAVTVEEEINKSIFDVRIRCYLCHKPLCDVEKLRHILEKARFIKLNCEWKGRCFHCWTSCMENILP
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation.  In turn, apoptosis induced by DNA damage is inhibited.  E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: FER3_METJA
Sequence: MKIEINENFCKGCDICIVVCPRGVFEKSKKLNKKGIYPPIPVNPEKCTKCNLCILQCPDQAISIELSQE
What are the official names of this protein?
Uncharacterized ferredoxin MJ0146.
Protein: YFNF_BACSU
Sequence: MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHRVLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVTYIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISFKHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGHWNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQETLPHIIQHMQTLDPEFNGFASKDDNK
What are the official names of this protein?
Uncharacterized protein YfnF.
Protein: MP2K1_HUMAN
Sequence: MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
What is the function of this protein?
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation.  RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2.  Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade.  Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126).  Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements.  One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis.  MAP2K1/MEK1 has been shown to export PPARG from the nucleus.  The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Protein: EFP_MYCBT
Sequence: MATTADFKNGLVLVIDGQLWTITEFQHVKPGKGPAFVRTKLKNVLSGKVVDKTFNAGVKVDTATVDRRDTTYLYRDGSDFVFMDSQDYEQHPLPEALVGDAARFLLEGMPVQVAFHNGVPLYIELPVTVELEVTHTEPGLQGDRSSAGTKPATLQTGAQINVPLFINTGDKLKVDSRDGSYLGRVNA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOLE_CLOBA
Sequence: MFNSDKVKIGICPIGWTNDDMPDLGKENTFEQAISEMALAGFKGTEIGNKYPKDVKVLKKALEMRNLQIASAWFSSFLTTKPYEETEKEFIAYRDFLHAMGSKVIVVSEQGHSIQGQMETPIFDGKYHFNEEEWNLLANGLNKLGQLAADKGMKIVYHHHMGTGVQTTEEIDKLMSVTDENLVYLLFDTGHLVYSGENPVEILKKYVHRIKHVHLKDIRPEIVSKVKNEKLSFLKGVRAGAFTVPGDGSIDFEPIFKILAENNYEGWLMIEAEQDPSIANPLEYAIKGRQYIKEKASI
What is the function of this protein?
Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).
What are the official names of this protein?
Inosose dehydratase, 2-keto-myo-inositol dehydratase, 2KMI dehydratase.
What is the protein family that this protein belongs to?
Belongs to the IolE/MocC family.
Protein: RIMM_SHIBS
Sequence: MVMMSKQLTAQAPVDPIVLGKMGSSYGIRGWLRVFSSTEDAESIFDYQPWFIQKAGQWQQVQLESWKHHNQDMIIKLKGVDDRDAANLLTNCEIVVDSSQLPQLEEGDYYWKDLMGCQVVTTEGYDLGKVVDMMETGSNDVLVIKANLKDAFGIKERLVPFLDGQVIKKVDLTTRSIEVDWDPGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_PSEAB
Sequence: MKHHLTPLDATQLDSWRALAAHRQELQDFRMRQAFIDDPERFKRFSFSACGLFLDFSKNLIRQDTIDLLVKLAEEARLSDAIRAMFDGEAINASERRPVLHTALRRPIGDKVLVDGVDVMPEVHRVLHQMTELVGYVHNGLWRGYTEKPITDVVNIGIGGSFLGPQLVSEALLPFAQKGVRCHYLANIDGSEFHELASRLNAETTLFIVSSKSFGTLETLKNAQAARAWYLAQGGTEEELYRHFIAVSSNKEAAIAFGIREENIFPMWDWVGGRYSLWSAIGLPIAMSIGISNFKELLSGAYNMDQHFQTAPFERNIPVLLGLLGVWYGDFWGANSHAILPYDYYLRNITDHLQQLDMESNGKSVRQDGTPVTSGTGPVIWGGVGCNGQHAYHQLLHQGTQLIPADFIVPVSSYNPVADHHQWLYANCLSQSQALMLGKSREEAEAELRAKGLPEAEVQRLAPHKVIPGNRPSNTLVVERISARRLGALIAMYEHKVYVQSILWGINAFDQWGVELGKELGKGVYSRLVGSEETPAEDASTQGLIDFFRGRHRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAT_HV1YB
Sequence: MEPVDPRLEPWNHPGSQPKTACNKCYCKKCCYHCMCCFTKKGLGISYGRKKRSQRRRPPKSSKDHQDPIPEQPLSRQQPGDQTGQKKQKKALEGKTEADPCD
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: DUSB_SHIFL
Sequence: MRIGQYQLRNRLIAAPMAGITDRPFRTLCYEMGAGLTVSEMMSSNPQVWESDKSRLRMVHIDEPGIRTVQIAGSAPKEMADAARINVESGAQIIDINMGCPAKKVNRKLAGSALLQYPDVVKSILTEVVNAVDVPVTLKIRTGWAPEHRNCEEIAQLAEDCGIQALTIHGRTRACLFNGEAEYDSIRAVKQKVSIPVIANGDITDPLKARAVLDYTGADALMIGRAAQGRPWIFREIQHYLDTGELLPPLPLAEVKRLLCAHVRELHDFYGPAKGYRIARKHVSWYLQEHAPNDQFRRTFNAIEDASEQLEALEAYFENFA
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
What are the official names of this protein?
tRNA-dihydrouridine synthase B.
What is the protein family that this protein belongs to?
Belongs to the Dus family. DusB subfamily.
Protein: GRPR_HUMAN
Sequence: MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
What is the function of this protein?
Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761).  Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation.  Contributes to the regulation of food intake.  Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain.  Contributes primarily to nonhistaminergic itch sensation.  In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity).  In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity).  Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
What are the official names of this protein?
Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRC_ROSDO
Sequence: MTKTLTIRRPDDWHLHLRDGAMLRAVLPETTAHFARAIIMPNLVPPVVTFAQAQDYHARILAALPEGAEFTPLMTLYLTEDTDPDDVAAAHANGLVHAVKLYPAGATTNSASGVANFDNIRAVLERMAEIGLPLCVHGEVTDDDIDIFDREAVFIDRVLDPIRQATPGLRVVMEHITTRNAVDYATAQDDTLGATITTHHLVINRNHILAGGIKPHYYCLPVAKREEHRLALRAAATSGDARFFLGTDSAPHTDANKLLPCGCAGCFTATNTMSILAHVFEEEQALERLEGFASLHGPAFYRLPANEARLTLTKTPATFPSHIETEDGPVTVFDPGFVPNWTVV
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: PANC_XANCP
Sequence: MIQTITDLSALRALVTGWKREGLRVALVPTMGNLHAGHYSLVMLARQYADRVVSSVFVNPTQFGPNEDFARYPRTPEADMRGLEDAGCDALWLPDVDTMYPLGTALATPIHAPGVSDVLEGVCRPGHFDGVCTVVARLFNQVQPDVAAFGKKDYQQLAVIRQMVADLAFPIEILGGSIVREADGLAMSSRNQYLSADDRPISAQIRKVLLQMRDSHAAGVPRLQVEAAATQALEAVGFRVDYTALRLPDLSEPDDGASNPAAGPRVALIAARIGSTRLIDNLEF
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U496K_ARATH
Sequence: MLKVKNFLGSRLKSFPTRKGKSDKECCRSLTSKLSVNEEYKEAFRTNSYLETRTKAEDQLGITSCSKLSSSSPSPSSSSDLSFHSHFTDYLLDPPQETLDALMQDSSLDNLIVTFFDLSSEACDVCETLLQCLQQIKINHNKIKRVMKIGKRVCNGAKTLECSPEMLCALIFQELSRFAALKNPLCRIVNEAQFRIVHDANSDLLTKLTSKKRRIRRKIRFFKFCKKLGGYSLVITHSAIVITLLIIALHSILGVFAAPALLGLCSFCLLRKKKAKGRMHKSNKDTTLEKLGTQIDIAAKGMFILINDLDTLSRLAGRLCDEIEHRKTVAAMCAKSRKIEVLKEALREFNGHEEKFSDQLQELEEHLYLCFHTINRSRRLVLAQITGQSS
What are the official names of this protein?
UPF0496 protein At1g20180.
What is the protein family that this protein belongs to?
Belongs to the UPF0496 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ARGC_KOSOT
Sequence: MIRVGIIGATGYTGLELVRILTNHPDVKITFLSSRSFAGKKLNDVYPFSLKNETLEEIDPEKISKNCDVVFTALPAGVSYEIARKLKDVRIIDLGADFRFDDPAVYEEWYSKKLPDYDPTERVYGLTELYREKIKNARFVGNPGCYPTSVLLATAPLLKNGSLDEETIIVDSKSGVSGAGKKESIDYSFSELSGSLKAYNVSKHRHVPEMEQEMSKLCGKRLKLVFTPHLVPMVRGILSTIYVKTDLSLDEVYELYREYYGKEKFIHVLQPGVYPSTKWTYGSNHAFISMAKDDRTDTLILISVIDNLVKGASGQAVQNMNVMFSLAEDAGLSFNPIYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_CHLT3
Sequence: MKQDKMAEVQSHACNQKARVYLETYGCQMNFSDTEIISSILSDAGYAIAESEQVADIIFLNTCAVRENAEQRIRNRLQNLRPLKKQNPKLIVGVLGCMAERLREKLFQEEKIVDLIAGPDAYRTLPNLLDLAESGEKAANVMLSLEETYADINPLRKNGHSAFLAIMRGCDNMCAFCIVPYTRGRERSRPMTSILDELKQLSDEGTREVTLLGQNVNSYYDENSGTRFANLMDKASLVNPNMRIRFTTSHPKDISSELIDVIAERKNLCEFIHLPVQSGSSRMLELMNRGHTREDYLEKIALIKSKIPNCSISTDMISGFCTETEADHAATLSLLREVRYDYAFTFVYSVRPNTPAATRLNDDVPDDVKQRRLSEVIALQQKISAELYRNDIGNTHEVLIEGESKRSSDMWMGRARNNRVVVFPKNGAQVGDFVNVKITDATSATLIGNAL
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUP4_ARATH
Sequence: MSDGRVNADPQQEENMVKPPVKRSLTLLIVTYFFLFFGSIASSLLAKYYFVYGGSSRWVSTWVQSAGFPLLLILIYFPHYVLKTTTRRPFTRFTLRHLIFSVLIGLVLGFNNFLFSWGTSYLPVSTSSLLLSTQLVFTLILSRIIVKQKITFSNLNCVVLLTLSSVLLALDSSKDKPSGLTKTKYFIGYVSTIGAGLLFALYLPVTEKLYRTVYCYAMVMEVQLVMEFAATVFATIGMACEGGFKEMVKEANHVFTKGPTFYWTFAILANVVTWQLSFAATSGMVYLTSGITGGICMTALLAMNVIGGVVAYGDVFGGVKIVSTVLCIWGFSSYTYGMYMKMKKEEKEKGEYSGVKTTEDSGEMEVEMGNVKDDVAAADDRA
What are the official names of this protein?
Probable purine permease 4, AtPUP4.
What is the protein family that this protein belongs to?
Belongs to the purine permeases (TC 2.A.7.14) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RUVA_ACHLI
Sequence: MYRYIKGIVTQINPQHIVVENNGVGYLVLSPVPYQYKIGEETTVVTYLHVREDIFQLYGFKDEETLNLFLKLISVSGIGPKSAMSIVAFDDTNKIIAAIETSDAKYLTKFPGIGMKSAQQIILDLKGKLVNDELDMQLLSDNSKDVAAALEALGYNKKEIAKSLKHVNFDQDLNKALKEALAILLK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: SCNA1_PERAM
Sequence: MADNSPLIREERQRLFRPYTRAMLTAPSAQPAKENGKTEENKDNSRDKGRGANKDRDGSAHPDQALEQGSRLPARMRNIFPAELASTPLEDFDPFYKNKKTFVVVTKAGDIFRFSGEKSLWMLDPFTPIRRVAISTMVQPIFSYFIMITILIHCIFMIMPATQTTYILELVFLSIYTIEVVVKVLARGFILHPFAYLRDPWNWLDFLVTLIGYITLVVDLGHLYALRAFRVLRSWRTVTIVPGWRTIVDALSLSITSLKDLVLLLLFSLFVFAVLGLQIYMGVLTQKCVKHFPADGSWGNFTDERWFNYTSNSSHWYIPDDWIEYPLCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFLSVFRLVTLDYWEDLYQLALRSAGPWHILFFIIVVFYGTFCFLNFILAVVVMSYTHMVKRADEEKAAERELKKEKKAASVANNTANGQEQTTIEMNGDEAVVIDNNDQAARQQSDPETPAPSVTQRLTDFLCVWDCCVPWQKLQGAIGAVVLSPFFELFIAVIIVLNITFMALDHHDMNIEFERILRTGNYIFTSIYIVEAVLKIIALSPKFYFKDSWNVFDFIIVVFAILELGLEGVQGLSVFRSFRLLRVFRLAKFWPTLNNFMSVMTKSYGAFVNVMYVMFLLLFIFAIIGMQLFGMNYIDNMERFPDGDLPRWNFTDFLHSFMIVFRALCGEWIESMWDCMLVGDWSCIPFFVAVFFVGNLVILNLLIALLLNNYGSFCTSPTSDEEDSKDEDALAQIVRIFKRFKPNLNAVKLSPMKPDSEDIVESQEIQGNNIADAEDVLAGEFPPDCCCNAFYKCFPSRPARDSSVQRMWSNIRRVCFLLAKNKYFQKFVTAVLVITSVLLALEDIYLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGFKKYFTSKWYWLDFIVVVAYLLNFVLMCAGIEALQTLRLLRVFRLFRPLSKVNGMQVVTSTLVEAVPHIFNVILVGIFFWLVFAIMGVQLFAGKFYKCVDENSTVLSHEITMDRNDCLHENYTWENSPMNFDHVGNAYLSLLQVATFKGWLQIMNDAIDSREVHKQPIRETNIYMYLYFIFFIVFGSFFILKLFVCILIDIFRQQRRKAEGLSATDSRTQLIYRRAVMRTMSAKPVKRIPKPTCHPQSLMYDISVNRKFEYTMMILIILNVAVMAIDHYGQSMEFSEVLDYLNLIFIIIFFVECVIKVSGLRHHYFKDPWNIIDFLYVVLAIAGLMLSDVIEKYFISPTLLRILRILRVGRLLRYFQSARGMRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGMEFFMHIRDAGAIDDVYNFKTFGQSIILLFQLATSAGWDGVYFAIANEEDCRAPDHELGYPGNCGSRALGIAYLVSYLIITCLVVINMYAAVILDYVLEVYEDSKEGLTDDDYDMFFEVWQQFDPEATQYIRYDQLSELLEALQPPLQVQKPNKYKILSMNIPICKDDHIFYKDVLEALVKDVFSRRGSPVEAGDVQAPNVDEAEYKPVSSTLQRQREEYCVRLIQNAWRKHKQQN
What is the function of this protein?
Mediates the voltage-dependent sodium ion permeability of excitable membranes.
What are the official names of this protein?
Sodium channel protein PaFPC1, PaFPC1, NavPaS.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRD_RHIME
Sequence: MIGQLEHLARRGLFLFDPEAAHGLSIKALKSGLVPSCAAPADPRLGQTVAGLVFSNPIGMAAGYDKNAEVPEALLKIGFGFTEIGTVTPRPQAGNDKPRLFRLVEDEAVINRLGFNNEGHGAALARLKACSREALIGVNIGANKDSADRIADYVTGIRTFYAVARYFTANISSPNTPGLRDLQARESLSALLSAVLAARDDEARKGGRQVPVFLKIAPDLTEEGMDDIAAEVLAHGLDGLIVSNTTLSREGLKDRRQANEAGGLSGKPLFEKSTAVLARMRKRVGPHLPIIGVGGVCSAETAAEKIRAGADLVQLYSCMIYEGPGLPGRIVRGLSALCEREKLASIRDIRDSRLDYWSGRNV
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ILVC_CUPTR
Sequence: MKVFYDKDADLSLIKGKNVTIIGYGSQGHAHALNLKDSGVNVTVGLRKSGASWNKAVNAGLQVKEVAEAVKNADVVMILLPDEQIADVYKNEVHANIKEGAALAFAHGFNVHYGAVIPRADLDVIMIAPKAPGHTVRATYTQGGGVPHLIAVHQNKSGAARDIALSYATANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYEGGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLKDIQTGEYAKSFLLENKAGAPTLISRRRLNAEHEIEVVGEKLRAMMPWIAKNKMVDQSKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.