PharMolix/UniProtQA huggingface dataset:
Protein: CWC21_CANAL
Sequence: MSYNGIGLQSVRGSATSGHIQKNIANKISKPGHYESRKNQKSLMSKRADEAKQSQNKREAYKQIKSELTKHEQLRRIEVKCMDLQDELEEQGVEPDEIKARVDELRKKLNNKEFDENDAKSPTTTTPQPSRKDKQLKEDLENENKNKDGVFEYKRRYADKRN
What is the function of this protein?
Involved in pre-mRNA splicing.  May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome.  May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor CWC21.
What is the protein family that this protein belongs to?
Belongs to the CWC21 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y691_STAAS
Sequence: MENKYTHGVLFYHEHSGLKNINQGIGEVTTALSSICKHLSIQLSENEGDIIKYCQEIKTKNYAKDVDILFILGGDGTVNELINGVMTHDLQLPIGILPGGTFNDFTKTLNIAPNHKQASEQMISAQVGKYDVIKINNQYALNFVGLGLIVQNAENVQDGSKDIFGKLSYIGSTVKTLLNPTQFNYQLSIDDKTYSGETTMILTANGPFIGGSRIPLTDLSPQDGELNTFIFNEQSFSILNDIFKKRDSMNWNEITQGIEHIPGKKISLTTDPAMKVDIDGEISLETPIDIEVIPNAIQLLTVNDL
What is the function of this protein?
May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG).
What are the official names of this protein?
Putative lipid kinase SAS0691.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family.
Protein: ANMK_COXB1
Sequence: MPKERYIGLISGTSMDALDTALVQFDPLKIIATHGEPIPTELKKNLVALSTGTDNSIPSMGETDVALGRLFGEAVLTLLEKAKVSSDSIQAIGSHGQTIRHMPNGKHPFTLQIGDPNTIAALTGITTVADFRRRDMALGGQGAPLAPAFHEFLLRDQSENRLILNIGGIANLTFLPRDPEKSTIGFDTGPGNTLLDAWCLMNLNKDYDDQGQWAASGRVQEKLVAQLLAEPYFQTPPPKSTGREYFNLNWLKKNLNGEKFDPVDIQATLVELTARSVANCCRNFSMDSGSLWLCGGGARNHHLVNRLKVLCKPLRVTTTEEIGIHPDWLEAVCFAWLAKQTLEKKPGNLPSVTGAKKSAILGAIYWGEKFNY
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: SYDND_BURO0
Sequence: MSMRTEYCGLVTEHLLGQTVSLCGWVQRRRDHGGVIFIDLRDREGLVQVVCDPDRAEMFATAEGVRNEFCVQIKGLVRNRPEGTVNAGLKSGKIEVLCHELNVLNASVTPPFQLDDDNLSETTRLTHRVLDLRRPQMQHNLRLRYRVAIEARKYLDEQGFIDIETPMLTKSTPEGARDYLVPSRVNAGQFFALPQSPQLFKQLLMVANFDRYYQITKCFRDEDLRADRQPEFTQIDCETSFLGEQEIRDLFEDMIRHIFKTTIDVELDAKFPVMPYSEAMARFGSDKPDLRVQLEFTELTDAMKDVDFKVFSTPANAKDGRVAALRVPKGGELSRGDIDGYTEFVRIYGAKGLAWIKVNEKAKGRDGLQSPIVKNLHDASIAAILERTGAEDGDIIFFAADRAKVVNDSLGALRLKIGHSEFGKANGLVQAGWKPLWVVDFPMFEYDDEDARYVAAHHPFTSPKDEHLEYLETDPGRCLAKAYDMVLNGWEIGGGSVRIHREEVQSKVFRALKIGAEEAQLKFGFLLDALQYGAPPHGGIAFGLDRIVTMMAGADSIRDVIAFPKTQRAQDLLTQAPSPVDERQLRELHIRLRQPEQPKA
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
Protein: CA210_HUMAN
Sequence: MNETNKTLVGPSELPTASAVAPGPGTGARAWPVLVGFVLGAVVLSLLIALAAKCHLCRRYHASYRHRPLPETGRGGRPQVAEDEDDDGFIEDNYIQPGTGELGTEGSRDHFSL
What is the function of this protein?
May be involved in membrane trafficking between endosomes and plasma membrane.
What are the official names of this protein?
Type III endosome membrane protein TEMP, TEMP.
What are the subcellular locations of this protein?
Membrane; Single-pass type III membrane protein. Early endosome. Recycling endosome. Cell membrane. Note=Also localizes to tubular endosome structures.
Protein: SIA1A_MOUSE
Sequence: MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes.  Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP.  Confers constitutive instability to HIPK2 through proteasomal degradation.  It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling.  Has some overlapping function with SIAH2 (By similarity).  Required for completion of meiosis I in males (PubMed:11884614).  Induces apoptosis in cooperation with PEG3 (PubMed:10681424).  Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus.  GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity).  Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (PubMed:24809345).  Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1.
What are the official names of this protein?
E3 ubiquitin-protein ligase SIAH1A, RING-type E3 ubiquitin transferase SIAH1A, Seven in absentia homolog 1a, Siah-1a, Siah1a, mSiah-1a.
What is the protein family that this protein belongs to?
Belongs to the SINA (Seven in absentia) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Protein: Y142_AERPE
Sequence: MSRGRADTAGDCSKNGRRSRILHYLMAIYLLNGLPGGEYARFIKIARLLDVSPSTVSIMTRRLQMKGLVELIPNMGVRLTEQGLKILSNYLWKSAILEVLLARAGVDIDNCRGMGLRMAEGLSDEDAWILYKVLGEPKYCPHKKPIIPPDEINAENARQIALCCGISILQIPNNRLQPPS
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator APE_0142.
What is the protein family that this protein belongs to?
Belongs to the DtxR/MntR family.
Protein: RECF_CHLTE
Sequence: MRLDSISIANFRNHTLLEFEPGHSITNIYGRNGSGKTSILEAIHYCALTRGFSGNNDREYLKFGEELFTIRSSFTSGQGIATKVSITYSPKREKRILVNEQELQTFSSHIGTIPCVTFTPREMVIINGAPAERRRFIDTAICQYDRKYLSDLLLYRRILQQRNALLSSEQDPRVIDSALDVLTDQLVAIATEIVLVRKRFIEHFTSMLGGVYQWIPEGAEPSILYQSSLGHHENLYEKDKIQQVFRERFETLKQQELQRRQTLAGPHRDDLQFYLNKREIRKYASQGQQRAFLVAMKMTLQGYLYEASGEIPITLLDDLFSELDEVVSGTMVETLATKGQVIITSTEKKKGKGISFFSVDDYKSSKEP
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA2_FRATH
Sequence: MTNNTDKQTLKKLERQILRKTTQVINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFPEEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLCSRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYNGSIKAMPTKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKALSNISPSQMLDKELFDFINISKDDIQR
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase 2, Two-thiocytidine biosynthesis protein A 2, tRNA 2-thiocytidine biosynthesis protein TtcA 2.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DURC_STRGP
Sequence: CANSCSYGPLTWSCDGNTK
What is the function of this protein?
Is a potent inhibitor of human phospholipase A2.  Exhibits only a weak antibacterial activity against B. subtilis, and does not display antimicrobial activity against S. aureus, S. mitis, E. coli, K. pneumoniae, P. vulgaris and C. albicans.
What are the official names of this protein?
Lantibiotic duramycin C.
What is the protein family that this protein belongs to?
Belongs to the type B lantibiotic family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2965_BORPE
Sequence: MSSHSQEPVGEENFDDSEYDRPNKSQVKREMHALLDLGKELVELSPERLRQLPLEERLYEAIREAQRTTGREGRRRQIHFVGKLMRSAPAEAIRAQLDTWRNGSREETAAMHRLEALRERLLTDDDALTAVLQRNPDADIQHLRALIRAARKEAAANAALSQGQEPQRKQYRALFQALKNLSA
What are the official names of this protein?
UPF0307 protein BP2965.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: FMT_CHLTA
Sequence: MSLRVVYLGTPQFAATVLKTLLDAHTHIVGIVTRADKPQKRSSKLISSPVKQLALSKNIPLLQPIKTTDPAFLAQLREWQADVFIVVAYGVILKQELLDIPTYGCYNLHAGLLPAYRGAAPIQRCIMDGGVLSGNTVIRMDAGMDTGDIANVNYVAIGEDMTAGGLAEALAASGGELLLKTLQEIEAGTVRHVPQNEAMATLAPKLTKEEGGIHWDAPASQVYAHIRGVSPAPGAWTRYLSQGKGARRLGVLSARMESFSGNYGDPGEVLGVSGEDLLIACRQGALRLRMVQPEGKALMKAKDFFNGQSRLVSKLF
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: GLPK_SYMTH
Sequence: MNKGYVLALDQGTTSSRAILFNRDGRLVGQVNHEFRQIYPQPGWVEHDPREIWSTQLRAVQDVLARTGVRLSEVAAIGITNQRETTVVWDAETGEPVYNAIVWQCRRTAPICAELAARGWAPRIREKTGLVIDAYFSGTKVKWILDNVPGVREKAEQGRLRFGTIDAWLIWNLTGGRVHATDYSNASRTMLFNIHQLAWDEEILHELGIPASLLPRALPSSHVYGETDPAVLGAAIPIAGVAGDQQAALFGQACFQPGDAKNTYGTGCFMLMNTGDRAVPSESGLLTTIAWGIGDRVEYALEGSIFIGGAAVQWLRDELRFFDRAADSEALALSVPDSGGVYVVPAFVGLGAPYWDMYARGIVVGLTRGTGRAHITRATLESIAYQTRDVLGAMEKDSGIRLNRLKVDGGAVANNFLMQFQSDILGVPVERPKIAETTALGAAYLAGLATGFWRSQAELADKWALDRGFTPALPAEERERLYAGWRRAVERARGWAAE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: TPIS_JANMA
Sequence: MRRKLVAGNWKMNGSLAANTLLLTEIKSGLGNATSDVAVCVPSPYFAQCQGLLNGAAIALGAQDVSSHEAGAYTGEVSTSMLQEFDCRYVIVGHSERRAYFAETNELIAQKTVRALNAGLTPIVCVGETLDQREAGQTDSVVAEQLNVVLASIAASDLAKIVVAYEPVWAIGTGKTATPAMAQEVHAMLRKQLQAKNAEAAMQVRILYGGSMKPENAKELLAMSDIDGGLIGGAALKAADFLAIVHAA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_THEKO
Sequence: MAKLALIRLRSGIRARGEVRDTLAMLRLHRINHLVIVDDTPSYRGMIQKVKDYITWGEIDKETLAKLLRKRGRLIGNKPITDEYVKEKLGMTIEEFAEKVVNGEMKLRDLPNIKPVFRLHPPRGGLKGSKKRSFKEGGALGYRGEKINELIERML
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: VIF_SIVMB
Sequence: MENRWQVMIVWQVDRMRIKTWNSLVKHHMYVSRKARNWFYRHHYESNNPKISSEVHIPLGEAKLVITTYWGLTTGERAWHLGHGVSIEWRQRSYRTQIDPDLADQLIHLYYFDCFAESAIRKAILGQIVSPRCEYPTGHNKVGSLQYLALSTLIKSKPRRPPLPSVRKLAEDRWNNSQKTRDHKGNHIMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: PFKA_SALPK
Sequence: MIKKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAKRLTEMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFIVVPEVEFNREDLVAEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLEGHGGRCVGIQNEQLVHHDIIDAIENMKRPFKSDWMECAKKLY
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEAM1_MOUSE
Sequence: MELASAHLHKGQVPWGGLLLTASLLASWSPATTAEVTIEAVPPQVAEDNNVLLLVHNLPLALGAFAWYKGNTTAIDKEIARFVPNSNMNFTGQAYSGREIIYSNGSLLFQMITMKDMGVYTLDMTDENYRRTQATVRFHVHPILLKPNITSNNSNPVEGDDSVSLTCDSYTDPDNINYLWSRNGESLSEGDRLKLSEGNRTLTLLNVTRNDTGPYVCETRNPVSVNRSDPFSLNIIYGPDTPIISPSDIYLHPGSNLNLSCHAASNPPAQYFWLINEKPHASSQELFIPNITTNNSGTYTCFVNNSVTGLSRTTVKNITVLEPVTQPFLQVTNTTVKELDSVTLTCLSNDIGANIQWLFNSQSLQLTERMTLSQNNSILRIDPIKREDAGEYQCEISNPVSVRRSNSIKLDIIFDPTQGGLSDGAIAGIVIGVVAGVALIAGLAYFLYSRKSGGGSDQRDLTEHKPSTSNHNLAPSDNSPNKVDDVAYTVLNFNSQQPNRPTSAPSSPRATETVYSEVKKK
What is the function of this protein?
(Microbial infection) In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein.
What are the official names of this protein?
Carcinoembryonic antigen-related cell adhesion molecule 1, Biliary glycoprotein 1, BGP-1, Biliary glycoprotein D, MHVR1, Murine hepatitis virus receptor, MHV-R.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. CEA family.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Lateral cell membrane. Apical cell membrane. Basal cell membrane. Cell junction. Cell junction, adherens junction. Note=Canalicular domain of hepatocyte plasma membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions. Found as dimer in the solution. Predominantly localized to the lateral cell membranes. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Lateral cell membrane. Apical cell membrane. Basal cell membrane. Cell junction. Cell junction, adherens junction. Cytoplasmic vesicle, secretory vesicle. Note=Predominantly localized to the lateral cell membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity). Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (By similarity). SUBCELLULAR LOCATION: Cell projection, microvillus membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Note=Localized to the apical glycocalyx surface (By similarity). Colocalizes with CEACAM20 at the apical brush border of intestinal cells (PubMed:25908210).
Protein: UB2Q2_RABIT
Sequence: MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPPPAPPLLTLHCNITESYPSSSPIWFVDSDDPNLTSVLERLEDSKNNNSLRQQLKWLICELCRLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEEEEEEEMAEDIEDLDHYEMKEEEPINGRKSEDEGIEKENLAILEKIRKSQRQDHLNGAVSGSVQASDRLMKELRDIYRSQSYKTGIYSVELINDSLYDWHVKLQKVDPDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  In vitro catalyzes 'Lys-48'-linked polyubiquitination.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 Q2, E2 ubiquitin-conjugating enzyme Q2, Ubiquitin carrier protein Q2, Ubiquitin-conjugating enzyme UBCi, Ubiquitin-protein ligase Q2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSI_BACLD
Sequence: MGNEILKAPEGPPSDVERIKKESDYLRGTLKESMLEPLSAGISDDDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVATPEQWLVMDELARKYGNGTLKLTTRETFQMHGILKWNMKKTIQSIHSAMLDTIAACGDVNRNVMCTSNPYQSEIHREVYEWSKKLSDDLLPRTRAYHEIWLDEEKVAGTPDADEVEPMYGPLYLPRKFKIGIAVPPSNDIDVFSQDLGFIAIVEDDKLIGFNVAIGGGMGMTHGDKATYPQLAKVIGFCKPEQLYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLETVKNELENRLGWSLAEAKPYHFEHNGDRYGWVKGVKGRWHFTMFVEGGRVTDYDDYKLMTGLREIAKVHTGDIRLTANQNLIIANVTSQKKKKISELIEQFGLTDGKHYTALRRSSIACVALPTCGLAMAEAERYLPKLIDKIDEIVEENGLKNEEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLGAAFDGSRLSKMYRENIGEEEILKELRNILPRYAKERNEGERFGDFVIRAGIVKETTDGTNFHD
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: RL23_CLOBK
Sequence: MKLTNYDIIRRPLITEKTMASMADKKYTFVVDIHANKSQIKNAIETIFDVKVEDVKTARIMGKTKRVGVHIGKRPDYKKAIVKLTEDSKTIEFFEGL
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: MSCL_HISS2
Sequence: MSFIKEFREFAMRGNVIDMAVGVIIGGAFGKIVSSLVADVIMPILSFFTSSVDFKDLHIVLKEATDKTPAMTLKYGMFIQNIFDFIIIAFAIFLMIKALNKLKKEEPKVEKVITPSNEEKLLTEIRDLLKK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARGC_CALS8
Sequence: MIKASIIGASGYVGIELIRLLLKHPEVEISSIISSSNKDISIENTNPQFKKILNLTFKEFDIDLVKEADVVFCALPHGVSQEYVKVAYDLGKVVIDLSSDFRYKDLTRYSKDYGNHKYPELLNESSYGLCEIFREEIKSSKIVGNPGCYPTSAILGLAPLLKNKLIQKDSIIIDSKSGVSGAGKKADFAYSFCEVDENFKAYGVAKHRHTSEIEEKCSFLFGEDLNLSFTPHLLPVKRGILSTIYATFTKSLNKNELIEIYKEFYRDEFFIRIYEDSLPELKYVTGTNFVDIGLEVDKKTNRVIVISCIDNLIKGAAGQAIQNMNIKFSLNEKTGLVIVGEYF
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_PROM5
Sequence: MNILQNLKKSDPIISNLINSEKNRQETHLELIASENFASMAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIERAKQLFDADWANVQPHSGAQANAAVFLSLLNPGDTILGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVDKETNKLNFNVIRDIALATKPKLIICGYSAYPRTIDFKSFRSIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLILCKDKEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPNFVNYSKQVIKNAKVLSSTLINRGIDIVSGGTDNHIVLLDLRSINMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNDEAFIEVGEIIADRLLNPDDLLIEKECKERVLSLCNSFPLYEAKLESSIK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.