PharMolix/UniProtQA huggingface dataset:
Protein: NU2M_PODAN
Sequence: MIFISIIGLLLSNAVTLRQDMSVNFNRIALIDLIYCILHDTMSLSIINKGIGLHGGLLHITNITLIFHIFIFFLSILILQLTSFYPRKAWIPEHSSLKDIIYQKFLNYRTKIFNKMGEHMKIIEYPLILLFVISGAVFLMSTNDLVSIFLSIELQSYGLYLLSTIYRNSELSTAGGLIYFLLGGLSSCFILLGTSLLYINSGTTSLDGLYILNSISDVKDGAADMPALTSWYKSYYLNFALLVFSIGFLFKVSAAPFHFWSPDVYDAIPTIVTTFVAIIAKISIFIFLLELVYHTNNYLSEFSWTYLLLISSLFSLIIGTVVGLTQFRIKRLLAYSTISHVGFILLALSGCSIESTQAFIFYLIQYSISNLNVFIIIITIGFSLYGYITTNKEYKDLLDKNNSPIQVISQLKGYFYINPLLSLSLAITIFSFVGIPPLVGFFAKQMVLSAALDNGYIFLTLIAILTSVIGAVYYLNIIKKIFFYLPDHSINPSIGEFLFKKGLIFEAGDFKGRITLISSPFSITISIITLVILLFIFMNKEWLSMGTILVQVLFSN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TS23M_MAIZE
Sequence: MAADEARSVSRLHSEEDMHGKHHSTLWGDFFLHHVPCRPGQYSIMKDNVKIMKEEVKKMLLDVGSSDLSHKLECIDTLERLGLDYHYTKEIDELMCNVFEARDQDLDLTTTSQLFYLLRKHGYHVSSDVFLKFGDDKGDIVTDDARCLLRMYEAAHVRVNGEEILDNILIHTKRQLQCIVDDLEPTLQEEVRYALETPLFRRLNRVQARQFISTYEKSTTRNNMLLEFSKLDFNILLTLYCEELKDLTMWWKEFQAQANTAIYARDRMVEMHFWMMGVFFEPQYSYSRKMLTQLFMIVSVLDDLYDSHCTTEEGNAFTAALQRWDEEGVEQCPTYLRTLYTNIRATVKAIEEDLNLQNNKHAKLVKGLIIDMAMCYNAETEWRDKKYVPATVDEHLKISARSSGCMHLVSQGFISMGDVATSEALEWASTYPKIVRAVCIIARLANDIMSYKREASNNTMVSTVQTCAKEYGTTTVEQAIEKIRELIEEAWMDITHECLRQPQPMALLERAVNLARTMDFLYKDVDGYTDSRSIKGILDSLYVDIID
What is the function of this protein?
Component of the volatile terpenes biosynthesis pathways (Probable).  Sesquiterpene synthase that converts farnesyl diphosphate to (E)-beta-caryophyllene (By similarity).  Involved in indirect defense by producing volatile signals attracting natural enemies of herbivores (By similarity).
What are the official names of this protein?
(E)-beta-caryophyllene synthase, Terpene synthase 23.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_CHLCH
Sequence: MKFVDSASVFVQAGDGGRGCVSFRREKFVPKGGPDGGDGGRGGHVWLETNSHLTTLLDFKYKNKYIAERGVHGQGARKTGKDGVEVVIQVPCGTIVRNAATGEVIADLTEDAQKILIARGGRGGRGNQHFATSTHQAPRHAEPGQKGEEFTLDLELKLMADVGLVGFPNAGKSTLISVVSAARPKIADYPFTTLVPNLGIVRYDDYKSFVMADIPGIIEGAAEGRGLGLQFLRHIERTKVLAILIAVDSPDIEAEYQTILGELEKFSATLLQKPRIVVITKMDVTDEPLALQLAGEQTPIFAISAVAGQGLKELKDALWRIIVAERAVPTNQVPQGGE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1522_BURVG
Sequence: MDIAHDLQSIGAQEQALVFPQFDPARAWALGNRMHALATARGHAIAIDIATFGQPLFFAALAGATPDNADWVRRKRNVVAHFRRSSYAIGLRMQQAGATLADKHGLPISEYSPHGGSFPLTVAGAGVIGSITASGLPQRADHEFVVEALCAELGHDYAVLALERS
What are the official names of this protein?
UPF0303 protein Bcep1808_1522.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: TGT_MOUSE
Sequence: MAAVGSPGSLESAPRIMRLVAECSRSGARAGELRLPHGTVATPVFMPVGTQATMKGITTEQLDSLGCRICLGNTYHLGLRPGPELIRKAQGLHGFMNWPHNLLTDSGGFQMVSLFSLSEVTEEGVHFRSPYDGEETLLSPERSVEIQNALGSDIIMQLDHVVSSTVTGPLVEEAMHRSVRWLDRCIAAHKHPDKQNLFAIIQGGLNADLRTTCLKEMTKRDVPGFAIGGLSGGESKAQFWKMVALSTSMLPKDKPRYLMGVGYATDLVVCVALGCDMFDCVYPTRTARFGSALVPTGNLQLKKKQYAKDFSPINPECPCPTCQTHSRAFLHALLHSDNTTALHHLTVHNIAYQLQLLSAVRSSILEQRFPDFVRNFMRTMYGDHSLCPAWAVEALASVGIMLT
What is the function of this protein?
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:19414587, PubMed:29862811).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase catalytic subunit 1, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Weakly associates with mitochondria, possibly via QTRT2.
Protein: GLYA_ACET2
Sequence: MFNLNEISKIDPEVAKAIELEVNRQRNKIELIASENFVSKAVIEAMGTPLTNKYAEGYPGKRYYGGCEFVDIIENLAIERAKKIFGAEHANVQPHSGAQANMAVFFAVLNPGDTILGMNLSHGGHLSHGSPVNMSGKYYNVISYGVRKEDCRIDYDEVRKLAKEHRPKLIVAGASAYPRIIDFKAFRDIADEVGAYLMVDIAHIAGLVAAGLHPNPVPYAHFVTTTTHKTLRGPRGGLILCGNEHAKMIDKAVFPGIQGGPLMHVIAAKAVSFAEVLTDEFKQYQQQIVKNAKTLANALMEKGIDLVSGGTDNHLMLVDLRNKGLTGKYVQHILDEVCITVNKNGIPFDPESPFVTSGIRIGTPAVTARGMKEEDMVEIADLINLTITDYENSKEKVKERVRMLCEKYPLYQ
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUA1_ARATH
Sequence: MSLVWLEAMLPLGIIGGMLCIMGNSQYYIHKAYHGRPKHIGHDEWDVAMERRDKKVVEKAAAPSS
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA1 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: TSAD_CLOBB
Sequence: MDKKLILAIESSCDETSAAVVVNGREVLSNVISTQIDTHKKFGGVVPEVASRMHIEIIDYVVKKALEDANVSLDDIDAIGVTYGPGLIGALLVGLQYAKGLAFASKKPLIGVNHIQGHISANFIQYKDLKPPFISLVVSGGHTFIVSVNDFCDFEVIGKTRDDAVGEAYDKVARSLGLGYPGGPKIDKLAKEGDPDAISFPRAKFHEDTLDFSFSGVKSAVLNYLNKANMKGIEVNNADVAASFQKAVIDVLKDNVFLTCKKKNVNKIAIAGGVASNSCLRETLKKEGALRNIEILFPEPVLCTDNAAMIGSAAYFNYEKNYVSSFDINAKPNLKLGER
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LLDD_XANC5
Sequence: MIISAASDYRAAAQARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRLSTELFGETLAMPVALAPVGLTGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPTPGARYRDAHSGMSGPNASLRRMLQAVTHPRWAWDVGLLGRPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWIREFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLALGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMTLTGTHSIAEISADALSRVTRERAETISP
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MTR1_TRYB2
Sequence: MPAVADCTVVFPLRHDPASTHPDVSGLVGKAFERVNWRDAFDTFLAEERSALWAAKTAFDNTDTSAYIAARDALFPQAVSGVHGAVAFRNRAGHKLHETMEAVGLWEYLKGGATRAKGTFTFVDVCGGPGAFSQALFAMGKEHKLRLRGFGLTLRNVKGLDWYTDLPSRSFFPCYGIDGTGDVFKLENIESLCSLTCKENVRLVVADGGFDVPTEVVNFQETISCRIVYGQWLSAVKLLRPGGCFVLKLFDCFSPFTRAILFLTTHLYESVQVVKPRHSRVVNSERYLVCIGFIGAPKQWLEHFERCYQEGFVDNDNIPTVLPTSLFSGDKIFGADVERMSATIASNQVSGLHAILEKLQSKPAMEEVKS
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of spliced leader and U1 small nuclear RNAs.  Methylates the ribose of the first nucleotide of a m(7)GpppG-capped RNA to produce m(7)GpppNmp (cap1).  Cap1 modification is linked to higher levels of translation.  Recognizes a guanosine cap on RNA independent of its N(7) methylation status.
What are the official names of this protein?
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, Cap1 2'O-ribose methyltransferase 1, MTr1, TbMTr1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLMH_METM7
Sequence: MNITIISVGKIKEKYLSDAINEYSKRISRYSKIDIIEVADEKTPENPSEVEKSKILEKEAERILKYLKKDSFLITLEILGKELTSESLAKKINDLSISGKSDITFIIGGSLGLSKNISEISDFKLSFSKMTFPHQLMRVILLEQVYRSFRIINGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Putative ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_CHLTR
Sequence: MSLDKGTKEEITKKFQLHEKDTGSADVQIAILTEHITELKEHLKRSPKDQNSRLALLKLVGQRRKLLEYLNSTDTERYKNLIARLNLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: TRPE_ACETH
Sequence: MFYPTLDEVKIMAKDYNIIPVTMEVYADMETPISLFKRFEESSCCFLLESVEGGEKWARYSIIGKNPFLVVESYKNKTIIRERNGSQREVEGNPVEIIKGIMGKFKGANLPNLPRFNGGAVGYFGYDLIRHYENLPNVPEDDMGLPECHFMFTDEVLVYDHLKQKIHIIVNLHVNGNIERAYISAVDRIKTIHREILDTRWKTADNSVLSYNKKKNELAVTSNISKEDFCRNVLKAKQYIRDGDIFQVVLSQRLCVETNENPFNIYRALRVINPSPYMYYLKFGGYRIIGSSPEMLVRVENGIVETCPIAGTRKRGRTKEEDEALEKELLSDEKEIAEHVMLVDLGRNDIGRVSKFGTVAVKNLMHIERYSHVMHVVTNVQGEIREDKTPFDALMSILPAGTLSGAPKVRAMEIIDELETVKRGPYGGAIGYLSFNGNLDSCITIRTIILKDGKAYVQAGAGIVADSVPEREYEECYNKAMALLKAIEEAGEIR
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
What are the official names of this protein?
Anthranilate synthase component 1, AS, ASI.
What is the protein family that this protein belongs to?
Belongs to the anthranilate synthase component I family.
Protein: ADPRS_LATCH
Sequence: MSAVGRLAAVSLAQVRGALCGALLGDCMGAEFEGSDAVELPDVLEFVRLLEKEKKAGTLFYTDDTAMTRAVIQSLIAKPDFDEVDMAKRFAEEYKKEPTRGYGAGVVQVFKKLLSPKYSDVFQPAREQFDGKGSYGNGGAMRVASIALAYPNIQDVIKFARRSAQLTHASPLGYNGAILQALAVHFALQGELKRDTFLEQLIGEMERIEGGEMSASDAGEHDRPNEVKLPFCSRLKKIKEFLASSNVPKADIVDELGHGIAALESVPTAIYSFLHCMESDPDIPDLYNNLQRTIIYSISLGGDTDTIATMAGAIAGAYYGMDQVTPSWKRSCEAIVETEESAVKLYELYCKQLKTP
What is the function of this protein?
ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose (PubMed:30472116).  Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (PubMed:30472116).  Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity).  Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds (By similarity).  Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:30472116).  Also hydrolyzes free poly(ADP-ribose) in mitochondria (By similarity).  Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (By similarity).  Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers (By similarity).
What are the official names of this protein?
ADP-ribosylhydrolase ARH3, ADP-ribose glycohydrolase ARH3, LchARH3, ADP-ribosylhydrolase 3, O-acetyl-ADP-ribose deacetylase ARH3, Poly(ADP-ribose) glycohydrolase ARH3, [Protein ADP-ribosylarginine] hydrolase-like protein 2, [Protein ADP-ribosylserine] hydrolase.
What is the protein family that this protein belongs to?
Belongs to the ADP-ribosylglycohydrolase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Mitochondrion matrix. Note=Recruited to DNA lesion regions following DNA damage; ADP-D-ribose-recognition is required for recruitment to DNA damage sites.
Protein: SMO_MOUSE
Sequence: MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWLVEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLVAANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLMEAEILDADSDF
What is the function of this protein?
G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling.  Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched (By similarity).  When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes (PubMed:33886552).  Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia.  Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602).
What are the official names of this protein?
Protein smoothened.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, cilium.
Protein: ALKB8_XENTR
Sequence: MGSIDGTRPKLSKDNKKLLKKQAKAKHILLKHEGIETVLHLSQSLVVANGGLGNGVSRQQLLAVLERCGKVETLLMPPNKPYAFVTYSSAEEAIKAYSSLSGQELCGEDAEQPITLYLSFVEKVVVKEVLSPSLPPGLIIVEDFVSPEQERTMLESIDWDSETSSQKSLKHRQVKHYGYEFRYDNNNVDKDKPLPGGLPDFCTEALRKCVQRGLIKHDPDQLTINQYEPGQGIPPHVDTHSAFEDEILSLSLGAEIVMDFKHPNGSVVPVMLPQRSLLIMSGESRYLWTHGITPRKFDVIQVSEGQTVGTISGNSGELTLSKRSTRTSFTFRKVRHSPCDCAFPSECDSQQTQKEKSPPTVGELGASTLEREYVHKVYDDIAGHFSSTRHTPWPKIGDFLASLPKGSLVADVGCGNGKYLGVNKDLCMIGCDRSKNLVDICRERTFEAFVCDALSVPFRAGAFDACISIAVIHHFATEERRIAALQELIRLLRKGGKALIYVWALEQEYKKNKSKYLKESKTSQGPSSDALGTNLAVKAPLPIHTNRTSFHSQDLLVPWHLKPTNKSKVTPENKEQNEKEHGPDSVYHRFYHVFCEGELEAMCNRLSNVAVQHSYHDQGNWCVILEKL
What is the function of this protein?
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain.  Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA.  Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys).  Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly).  Required for normal survival after DNA damage.  May inhibit apoptosis and promote cell survival and angiogenesis (By similarity).
What are the official names of this protein?
Alkylated DNA repair protein alkB homolog 8, Probable alpha-ketoglutarate-dependent dioxygenase ABH8, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8.
What is the protein family that this protein belongs to?
Belongs to the alkB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Protein: RLR16_PLAVT
Sequence: MRGAFYIAIALLIVRSRTATGNAKSDVSRPYVVATGGESTKATPKRYLRGGLALSATNEERMDATVLSKDAKALATEGEDWLRLSLGPVGHSQTPQLKRKFDSLSAIDESSPSKKLATPDRAFTRRFRAEDPQLPKYSKIHQTFLNIPHMPHKISLTEAVLMYRMVNWKNGSSPTKQKSAEALLRLVERTSADDLERALGPTSVRLASQKKIRDEYFKNLTTMYARVHAFCHANPAECTNESTHSPLERKMKAPPDIVLFPLFNR
What is the function of this protein?
Effector that acts as an elicitor that induces cell death and promotes ROS accumulation in Nicotian benthamiana (PubMed:27242731, PubMed:28410577).  RxLR16-triggered cell death is dependent on SGT1, HSP90 and RAR1, but independent of the somatic embryogenesis receptor-like kinase SERK3/BAK1, indicating that it acts independently of the detection of cell surface pattern recognition receptors (PubMed:28410577).  Enhances the expressional levels of defense-associated genes involved in the salicylic acid-, jasmonate acid-, and ethylene-mediated signal transduction, resulting in disease resistance (PubMed:28410577).  However, as some other Plasmopara viticola RxLR effectors including RxLR1, RxLR10, RxLR30 and RxLR25, can suppress defense responses and disease resistance induced by RxLR16, it may not trigger host cell death or immune responses during physiological infection under natural conditions (PubMed:28410577).
What are the official names of this protein?
Secreted RxLR effector protein 16.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Note=Host nuclear localization is required to elicit cell death.
Protein: MOAB_STAEQ
Sequence: MHKHQHQNIHLNRPIHVAILTVSDTRDYDSDKGGQLIQSLINQHENHVDINHYRIVKDDIEAITHQLKLWLTSSNQLDVIITTGGTGISQRDVTIEAVRPLLTKELEGFGELFRYLSYTEDVGTRALLTRAIAGTCDSTLIFALPGSTGAIKLAIEKLIKPELSHLVFELNKDIRN
What is the function of this protein?
May be involved in the biosynthesis of molybdopterin.
What are the official names of this protein?
Molybdenum cofactor biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the MoaB/Mog family.
Protein: Y3704_OLEA2
Sequence: MLTDREVISTLDMLRNEHLDVRTVTLGISLFDCASDNFDRFATRVQDKISRYAEHLVATCDEVGEKYGIPVVNKRISISPMAVVGAPFGPDDMVRAAQVLDKAACNAGVDFLGGFTALVEKGMTKGDRALIDALPEALATTGRVCSSVNVGSSRSGINMDAVALMGDTIVQIAGRTADRDGIGCAKLVVFTNIPQDVPFMAGAYLGTGEPDVVINVGVSGPGVVKKAIDRAMQSGDRSLGDIAEVIKRTAFKVTRVGEIIGREVAERLGVPFGVADLSLAPAPQVGDSVGEIFQSVGLASIGVPGSTAVLAMLNDAVKKGGAFASSHVGGLSGAFIPVSEDLNIAEAAATGRLTLEKLEAMTSVCSVGLDMVAIPGDTPAATIAAIIADEMAIGMINNKTTAVRIIPVPGKKAGDTVSFGGLLGESAIMPVPGSGGSEKFIRLGGRMPAPIHSLKN
What are the official names of this protein?
UPF0210 protein Dde_3704.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: PNX36_SCODE
Sequence: MKVFIAVLSIAIVLIIIVSIQETTANTGEAETTFAVPNKKFTREDCKKECARRFTNGVLSKVIIAKLTGTKCYCKYKT
What are the official names of this protein?
Scoloptoxin SSD996.
What is the protein family that this protein belongs to?
Belongs to the scolopendra neurotoxin 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FL1_TOBAC
Sequence: MDPEAFSASLFKWDPRGAMPPPTRLLEAAVAPPPPPPVLPPPQPLSAAYSIRTRELGGLEELFQAYGIRYYTAAKIAELGFTVNTLLDMKDEELDDMMNSLSQIFRWELLVGERYGIKAAIRAERRRLEEEELRRRSHLLSDGGTNALDALSQEGLSEEPVQQQEREAVGSGGGGTTWEVVAAVGGGRMKQRRRKKVVSTGRERRGRASAEEDEETEEGQEDEWNINDAGGGISERQREHPFIVTEPGEVARGKKNGLDYLFHLYEQCRDFLIQVQNIAKERGEKCPTKVTNQVFRYAKKAGASYINKPKMRHYVHCYALHCLDEEASNALRRAFKERGENVGAWRQACYKPLVAIAARQGWDIDTIFNAHPRLAIWYVPTRLRQLCHSERSNAAAAASSSVSGGVGDHLPHF
What is the function of this protein?
Probable transcription factor that act to specify determinacy in the progenitor cells for both flowers and leaves.
What are the official names of this protein?
Floricaula/leafy homolog 1, NFL1.
What is the protein family that this protein belongs to?
Belongs to the FLO/LFY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLC2L_HUMAN
Sequence: MEPAREPPSRARPPPPLAARPAPAPAAPRPRSPAEAEARGPEGLLRRSGSGYEGSTSWKAALEDTTTRLLLGAIAVLLFAILVVMSILASKGCIKCEAPCPEDWLLYGRKCYFFSEEPRDWNTGRQYCHTHEAVLAVIQSQKELEFMFKFTRREPWIGLRRVGDEFHWVNGDPFDPDTFTIAGPGECVFVEPTRLVSTECLMTRPWVCSKMAYT
What are the official names of this protein?
C-type lectin domain family 2 member L.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.