PharMolix/UniProtQA huggingface dataset:
Protein: GGN4_GLARU
Sequence: MFTMKKSLLFLFFLGTISLSLCEEERSADEDDGGEMTEEEVKRGILDTLKQFAKGVGKDLVKGAAQGVLSTVSCKLAKTC
What is the function of this protein?
Has a non-hemolytic activity.  Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa.
What are the official names of this protein?
Gaegurin-4.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NFAM1_HUMAN
Sequence: MENQPVRWRALPGLPRPPGLPAAPWLLLGVLLLPGTLRLAGGQSVTHTGLPIMASLANTAISFSCRITYPYTPQFKVFTVSYFHEDLQGQRSPKKPTNCHPGLGTENQSHTLDCQVTLVLPGASATGTYYCSVHWPHSTVRGSGTFILVRDAGYREPPQSPQKLLLFGFTGLLSVLSVVGTALLLWNKKRMRGPGKDPTRKCPDPRSASSPKQHPSESVYTALQRRETEVYACIENEDGSSPTAKQSPLSQERPHRFEDDGELNLVYENL
What is the function of this protein?
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters.  Activates the transcription of IL-13 and TNF-alpha promoters.  May be involved in the regulation of B-cell, but not T-cell, development.  Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
What are the official names of this protein?
NFAT activation molecule 1, Calcineurin/NFAT-activating ITAM-containing protein, NFAT-activating protein with ITAM motif 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Partially recruited to lipid rafts upon BCR stimulation.
Protein: ERF1_MOUSE
Sequence: MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGFGGIGGILRYRVDFQGMEYQGGDDEFFDLDDY
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity).  Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity).
What are the official names of this protein?
Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, eRF1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
Protein: NACC1_RAT
Sequence: MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHPEEAPSSEPQSPVAQILGWPACSTPLPLVSRVKTEQELDSVQCTPMAKRLWDSSQKEAGGSGGNNGSRKMAKFSTPDLAPNRMPQPVSVATATAAVAVVAVGGCVSGPSMSERTSPGTSSAYTSDSPSSYHNEEDEEEDAGEEGTDEQYRQICNMYTMYSMLNVGQTVEKVEALPEQVVLESHSRIRVRQDLASLPAELINQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAGTRHKVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMNAIAADMCTNARRVVRKSWLPKTKPLHLVEGDNYSSFISDTGKIEPDMMSMEHSFETASHDGEAGPSAEVLQ
What is the function of this protein?
Functions as a transcriptional repressor.  Isoform 1 is a stronger transcriptional repressor than isoform 2.  Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4.  Contributes to tumor progression, and tumor cell proliferation and survival.  This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1.  Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
What are the official names of this protein?
Nucleus accumbens-associated protein 1, NAC-1, BTB/POZ domain-containing protein 14B.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Punctate distribution in nucleus. In differentiated PC12 cells diffusely distributed in the cytoplasm and is dependent on phosphorylation.
Protein: CGT_RAT
Sequence: MKSYTPYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVFLLSEGRDIDPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRMGVSFLVLPKYERIMQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVDGAQEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLDIAFVLLLGAVALYFIVSYVTKFIYRKVKSLCSRSTHSTVNGHYQNGILNGRYKGNGHIKHEKKVK
What is the function of this protein?
Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.  Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (PubMed:8713090).
What are the official names of this protein?
2-hydroxyacylsphingosine 1-beta-galactosyltransferase, Ceramide UDP-galactosyltransferase, CGalT, Cerebroside synthase, UDP-galactose-ceramide galactosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Endoplasmic reticulum.
Protein: QUEC_PROMM
Sequence: MSSMIHSTTIALLSGGLDSATAAALAVEAGQKVIGLSFDYGQRHRKELQAADALAAHMGLSEHHVISVNLGSWGGSSLTDLTQTVPSEGVVDGVIPNTYVPGRNTVFIAIGLSLAEARNANQLVLGINAMDYSGYPDCRPDYLRAYQSLADLANKAGREGHGIKLWAPLIDWNKKQIVQEALRLGVPIDKTWSCYSGGDHACGICDSCRIRDAALSEAGRSDLCSKSTP
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: Y2505_BACCQ
Sequence: MNKLSTKLVVAIGIGAALYGILGLWGFSIAPNTFIKPALAILTVFGALFGPVAGLLIGLIGHTVTDTIAGWGIWWGWVISSGIIGFAMGFIQKRVGFSVKNGTYNKGDISYLAITGLIGIVIAIIFAGAFDIIVMGEPFDKIVIQVLGATIADVIVFLVLGLPITIGLAKSNKKHAHLKIEK
What are the official names of this protein?
UPF0397 protein BCQ_2505.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SWC4_GIBZE
Sequence: MTSSDVRDVLNLGDGTVGPRSSKKQKLAAPRPNLKGLAREVQNLGGDNPIAIVPEVTHFKKRRFTSRKPTAKWEMRPFKNSARSDSNFTLRHWRRKDEKQEGIDESQEQISQGDQPQPQKNELEDSAFAKYNVQVSVPQYSEGQYQQSLQHVDWTKEETDYLLELAQDFDLRWPLIWDRYEWNPPATNGEADDDGDESKAIVPATRSRTLEDLKARYYEVASKMMAAQKPVQYMTQPEFSLHELMAHFNPQQEKLRKEFALNALTRSREEAREEESLLLEIKRILARSERFNDERRELYNRLDYPRSDTDINAFKSSAGLQNLLQNLVTADKTKKRKSLMPGDVNSPAGTVPPQTAAAASAAATAAAVAQEAGRRESTAASTGPRESTGPAPTPAAANNKKGQQQQQERRKLTTQEELLYGVTHHDRLGSGPTFRTEKINKLFSHKSNQQQMRITNVLNELDVPNKLIMPTAATTHQYEQLLAAVNSLLDARKVSDKLDQEIKTEQAKKAERQKAMAPPEAESTAENGQTGQEKKDGDDGEACAAAVTADTSKEETNGDATSAAGDATKDGLETAVLTSEAPDAPPKETEQNIDERPGSSGAPHKRSASVLSNVSDKSNKRQKK
What is the function of this protein?
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).
What are the official names of this protein?
SWR1-complex protein 4.
What is the protein family that this protein belongs to?
Belongs to the SWC4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPP_CAMJR
Sequence: MFIPYVIEKSSRGERSYDIYSRLLKDRIIMLSGEIHDELAASIVAQLLFLEAEDPTKDIYLYINSPGGVITSGFSIYDTMNYIKPDVCTICIGQAASMGAFLLSCGAEGKRFALPNSRIMIHQPLGGARGQATDIEIQAKEILRLKTILNDILAKNTKQKVAKIAKDTERDFFMSAQEAKEYGLIDKVLEKSFK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALGX_PSESM
Sequence: MHAHLIKLLSLSSLTAALMAAAGVARADDAQAPTFKAEPCCSLCPAAHDAKNYTTRYQQNFTTLVQAQGDWLFRTQEDLRTEFDTTPGGYRRMKELHDAFKSKGVELVVVYQPTRGLVDRNKLFPAERDKFDYDKALKNYQAMLGRFSKMGYWVPDLSPLTNEQQAHDFYFRGDQHWTPYGAQRTAKIVAETVKKVPGYSSIPKREFESHISGRMGKTGTLHNMAGQLCGTSYAVQYMDQFTTEPKGEAGDGDLFGDAGNPEITLVGTSHSGKNYNFAGFLQEYMGADVLNVAFPGGGLEGSMLQYLGSEDFQKRPPKILIWEFSPLYRLDQETIYRQMMALLDNGCEGKPAVMSASTTLKPGNNEVLVNGKNGIKDIRNGSNQIDIRFDDTSVKTLQARLWYMNGRHEDLKIEKPETSDTDGRFAFELREDEDWADQQLLALEIQGPEAGTAPQKVAAKVCKRNVFPSAAKHTAQAGL
What is the function of this protein?
Plays two roles in the biosynthesis of the exopolysaccharide alginate: protects alginate from degradation as the polymer traverses the periplasm, and also plays a role in its O-acetylation.  Probably has acetyltransferase activity in vivo (By similarity).
What are the official names of this protein?
Alginate biosynthesis protein AlgX, Probable alginate O-acetyltransferase AlgX.
What is the protein family that this protein belongs to?
Belongs to the AlgX family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GLB1_ARTSX
Sequence: DISHFQNFRVTLLEYLTENGMNGAQKASWNKAFDAFEKYIIMGLSSLERVDPITGLSGLEKNAILDTWGKVRGNLQEVGKATFGKLFAAHPEYQQMFRFFQGVQLAFLVQSPKFAAHTQRVVSALDQTLLALNRPSDQFVYMIKELGLDHINRGTDRSFVEYLKESLGDSVDEFTVQSFGEVIVNFLNEGLRQA
What are the official names of this protein?
Extracellular globin-E1.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: AAMS_STRVT
Sequence: MAKMSTTHEEIALAGPDGIPAVDLRDLIDAQLYMPFPFERNPHASEAAAGVDHWLSTWGLTDDPAVAAMISCTRPAELAAFNGPDMDSGLLQIAANQIAYQFVFDDRAEDIGRHSPGRLLPMLSESVAILRDGQPPTTPLGAALADLHRQVQERCTPAQAARWAWNSREYVHGLLYEAVAQAHPAPVESGLCRSIRSLIAGVEPFYPLCEAAQRCELAPEELHHPAMRRLSRLSADAAVWIPDLFSAVKEQRAGGMINLALAYRRTHRCSLPAAVTLAVRHINSTIREFEDLYGEVRPELSPSGIGYVEGMAGWIRGCYFWSRTVPRYADTLTAPAGL
What is the function of this protein?
Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene (1R,6S,7S)-(-)-alpha-amorphene via a probable 1,6-cyclization, which could involve the abstraction of the pyrophosphate from FPP to yield a (R)-bisabolyl cation (PubMed:23307484, PubMed:27666571, PubMed:27829890).  The only accepted substrate is (2E,6E)-farnesyl diphosphate (FPP) (PubMed:27829890).
What are the official names of this protein?
(-)-alpha-amorphene synthase ((2E,6E)-farnesyl diphosphate cyclizing), Terpene synthase, Type I terpene cyclase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: PAN2_CANAL
Sequence: MDGWSEVLRIPSSVFATDNYNNPTTIVNITSLQFDSVQNFIWCGDSRGYTRSFTGSFATNSLYGNLQLYPYTKFHTSDVNYNNPIKQILSHREGILSLSNNAISFNSRRGLSKLQVTSKTFNNNATTENKFNNLQAMTFNCNSFNDVVVGTDTSMMKFDLNKPNVLSSFDHQGGISLLNNLGKFLTIANSNGSLDIFDPVSNSTMKTFSAHNGFISNLDVRGNYIATCGYSIKPKRYYHNQPAEYIVDPLVNIYDTRIMRAIAPVPFPAGAASVKFHPKLPNIIIIASTSGQMQFVDIFDQTNVYLYQADLAIPTTTTTTINNKPRMSNLEISENGDFLVFNDNCDNMHLWSISPSSKDFVNFPQPVEQPDIIDSNFEIIDIDANVPLSIVGMPYYKELLLSNYPNDLRFVKETAKLPEPIDIELILENETRNNGTKKFFPYDKLKYGPGNVYKPYQSLKDNKENKEISIPKFISERSTTTTTTTKELKADNDGKFIDDSIFQYKFQGKLNKVPNCYSRLQIQYSKFGIKDFDFSYYNKTKECCGLENHTDNSYINSLLQLYRFQSSIYNQVVGSLSKEWLPNDITTIITTNNPEGSSILNELGYLFDMMFKAQSNNVKIYNLSQVLNHHPNAQKLLNNNELLNLNSQQVRDLVIEFNNFLLTTLHQDFQTQFQENFNLTELKYEIEIKGNGTSCPMYDKHQGSMFSLELITPPSNMLNKMSILINNNNNNNNPQYQPEPISSLDNIRRNLNILTYLEYSMNQYKTIPCQQHNHSYPHNLEIQTSIVHLPSVLTINVNLSNPEFKIINNFTQWLVPEFYAVKSKSISGKNGYSFKEIDHPTPNSATQESGKYKYKYELLGYVCEINHQSDIVSGAHNLVAFIKVNNNGGWYLFNDFLVMPIPEEEVFDLQPSWKKPIVIMYQQTNQPSFNYLTTTTTTTTTTTTFSNAGKYDDSILYRDHFAEGIRKGHQLEYELLTRKESPQPGSLVAIDAEFVMLKPEELEIHYDGYKKLIKPKQLSLARISVLRENGIPFIDDYIVHTSDIYDYLTNFSGIEPNDLNLTLSNRENLVTLQTAYRKLWLLLNLGVIFVGHGLYNDFRTINLQVPERQIRDTAVIYYKSDFKRQLSLKFLAYVMLKEKVQSGNHDSIEDANTALLLYKKYQNLYNKEDFESILNYIYSEGQQLRFKVPE
What is the function of this protein?
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex catalytic subunit PAN2, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. PAN2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IQCF5_HUMAN
Sequence: MGPEEKTIMTERSAAVFIQAWWRGMLVRRTLLHAALRAWIIQCWWRQVLEKLLAKRRRMVLEFYVQQEWAAVRLQSWVRMWCVRQRYCRLLNAVRIIQVYWRWHSCHSRVFIEGHYELKENQLNIQLEISLGLQACKVQQCIPLPLKE
What are the official names of this protein?
IQ domain-containing protein F5.
Protein: RAB3B_RAT
Sequence: MASVTDGNTGIRDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVIPTEKGRLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSMDTDPSVLGASKTTRLSDTPPLLQQNCSC
What is the function of this protein?
Protein transport.  Probably involved in vesicular traffic (By similarity).
What are the official names of this protein?
Ras-related protein Rab-3B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Note=Colocalizes with GAS8/DRC4 in the Golgi apparatus.
Protein: BUB3_HUMAN
Sequence: MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYEMDDTEHPEDGIFIRQVTDAETKPKSPCT
What is the function of this protein?
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments.  Promotes the formation of stable end-on bipolar attachments.  Necessary for kinetochore localization of BUB1.  Regulates chromosome segregation during oocyte meiosis.  The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20.  This complex can also phosphorylate MAD1L1.
What are the official names of this protein?
Mitotic checkpoint protein BUB3.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BUB3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I- anaphase I (MI-AI) transition.
Protein: YTHA_BACSU
Sequence: MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKDDHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAFFVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNGKITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRKALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDPNEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLILYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLKTSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES
What is the function of this protein?
May have a role in sporulation.  Can compensate for the loss of cytochrome aa3.
What are the official names of this protein?
Putative cytochrome bd menaquinol oxidase subunit I.
What is the protein family that this protein belongs to?
Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPPH_VARPS
Sequence: MLDRDGFRPNVGIILLNQRNQVFWGKRIRTHSWQFPQGGIDRGESPEQAMFRELHEEVGLHPEHVRIVARTRDWLRYEVPDRFIRRDARGHYKGQKQIWYLLQLIGHDWDLNLRATDHPEFDAWRWHDYWVPLDVVVEFKRGVYEMALTELARYLPRQDFRNRFLRSNVRAREFERHMPDGGAPAGLDLPPGGSFDPHPDITSASDDPSPPPHNKAPFLPSQR
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: YECE_ECOLI
Sequence: MIYIGLPQWSHPKWVRLGITSLEEYARHFNCVEGNTTLYALPKPEVVLRWREQTTDDFRFCFKFPATISHQAALRHCDDLVTEFLTRMSPLAPRIGQYWLQLPATFGPRELPALWHFLDSLPGEFNYGVEVRHPQFFAKGEEEQTLNRGLHQRGVNRVILDSRPVHAARPHSEAIRDAQRKKPKVPVHAVLTATNPLIRFIGSDDMTQNRELFQVWLQKLAQWHQTTTPYLFLHTPDIAQAPELVHTLWEDLRKTLPEIGAVPAIPQQSSLF
What are the official names of this protein?
UPF0759 protein YecE.
What is the protein family that this protein belongs to?
Belongs to the UPF0759 family.
Protein: CAPSD_TCV
Sequence: MENDPRVRKFASDGAQWAIKWQKKGWSTLTSRQKQTARAAMGIKLSPVAQPVQKVTRLSAPVALAYREVSTQPRVSTARDGITRSGSELITTLKKNTDTEPKYTTAVLNPSEPGTFNQLIKEAAQYEKYRFTSLRFRYSPMSPSTTGGKVALAFDRDAAKPPPNDLASLYNIEGCVSSVPWTGFILTVPTDSTDRFVADGISDPKLVDFGKLIMATYGQGANDAAQLGEVRVEYTVQLKNRTGSTSDAQIGDFAGVKDGPRLVSWSKTKGTAGWEHDCHFLGTGNFSLTLFYEKAPVSGLENADASDFSVLGEAAAGSVQWAGVKVAERGQGVKMVTTEEQPKGKWQALRI
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins.  Also acts as a suppressor of RNA-mediated gene silencing known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  May suppress other innate immunity by binding to host TIP protein, thereby preventing it to migrate in the nucleus where it could trigger an antiviral response (PubMed:11041886, PubMed:24418554).
What are the official names of this protein?
Capsid protein, Coat protein, p38.
What is the protein family that this protein belongs to?
Belongs to the icosahedral plant coat protein family.
What are the subcellular locations of this protein?
Virion.
Protein: PHCB2_PSETP
Sequence: MLDAFTKVVAQADTRGRFVSDSQIDALKQLVADGTKRLDVVNRITASSSSIVTDAARALFEDQPQLIAPGGNAYTNRRIAACMRDMDIILRYVTYAVFSGDASVLEDRCLNGLRETYSALGVPGGSVAVGIDKMKAAAIALANDPNGVTRGDCSALMSELASYFDKAAAAVG
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex (phycobilisome, PBS).  Phycocyanin is the major phycobiliprotein in the PBS rod.
What are the official names of this protein?
C-phycocyanin-2 beta subunit.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Part of the phycobilisome rod.
Protein: CWP06_ARATH
Sequence: EYFIGVN
What are the official names of this protein?
42 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: PFD1_ARATH
Sequence: MADEATRAAFMEIQASMIELTGKLKQVQNQMRNKEGDRKRAFLTLEELRPLPEETNTYKSIGRTFVLEPKTVLEGEQEQKLKDSEAAVASLQTSKEYLEKQVAEVENNLRELLQQEPGIAQQIMSMSM
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it (PubMed:19825635).  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (PubMed:19825635).  Together with other chaperonins, contribute to the regulation of gene expression by modulating the spliceosome function on pre-mRNA splicing post-transcriptionally by acting as a co-chaperone of Hsp90 to control levels of LSM8 (By similarity).  Required for microtubules (MTs) organization and dynamicity (By similarity).  Involved in the process leading to microtubules dissociation in response to gibberellic acid (GA) probably due to the DELLA proteins-mediated translocation of the prefoldin co-chaperone complex from the cytoplasm to the nucleus (By similarity).
What are the official names of this protein?
Prefoldin subunit 1, Gene involved in microtubule biogenesis 6.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the presence of gibberellic acid (GA) and at room temperature, the prefoldin complex stays in the cytoplasm and is functional (By similarity). But in the absence of GA or in response to cold, the prefoldin complex is localized to the nucleus in the presence of DELLA proteins, which severely compromises alpha/beta-tubulin heterodimer availability, thus affecting microtubules (MTs) organization (By similarity). This changing subcellular localization follows a daily rhythm coordinated oscillation (By similarity).
Protein: 3SO3_MICPY
Sequence: LLCLQKYSPGRETSQTCLAGENICFKKWKKGEKTSRXGCAVTCPKXK
What are the official names of this protein?
Short neurotoxin D2A.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group III sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: REN_PHUV
Sequence: MDLRTGVPITAAQAANGVFIWELRNPLYFKIRLVETPMYTRSRVFHIQVRANHNMRTALGLHKAYFNFQVWTTLTTISGQIYLNRFKLLVMFYLDNLGLISVNNVIRAVSFATDKRYVNAVLENHEIIYKLY
What is the function of this protein?
Increases viral DNA accumulation.  Enhances infectivity and symptom expression (By similarity).
What are the official names of this protein?
Replication enhancer protein, REn, Protein AC3, Protein AL3.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae replication enhancer protein family.
Protein: RUVA_PSYIN
Sequence: MIGRLRGVLLEKQPPEVLIEVSGIGYEVQLPMSSFYALPDAGQEAIIYTHFVVREDAQLLYGFADKHERAMFRELIKVNGVGPKLALAILSGMSANQFVQCIHNDAVTTLVKLPGVGKKTAERLVVEMKDRLKNWTGADLLTPASDKMVFENEFTNSAASGNAKDEAISALVSLGYKPVLAEKAIQQVYVEGMDCEALIRSSLKSML
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.