PharMolix/UniProtQA huggingface dataset:
Protein: KR151_HUMAN
Sequence: MSYNCSSGNFSSCCFGSYLRYPVSTYNLFYPSNAIYSPNTCQLGSSLYNGCQETYCEPTSCQTSCTLARSYQTSCYCPKNSIFCSPRQTNYIRSLGCGNTGLGSLGCGSTGFQSLDCGSSFYHPTTFSSRNFQATCY
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 15-1.
What is the protein family that this protein belongs to?
Belongs to the PMG family.
Protein: DNMT3_ARATH
Sequence: MKTKAGKQKKRSVDSDDDVSRERRPKRATSGTNFKEKSLRFSEKYETVEAKKEQIVGDDEKEEKGVRFQSFGRVENWTISGYEDGSPVIWISTVIADYDCRKPSKKYKKLYDYFFEKACACVEVCKNLSTNPDTSLKELLAAVVRSMNGRKIFSSGGVIQEFVISQGEFIYNQLAGLDETSKNHETKFVDNRVLVSLRDESRKIHKAFSNVALRIDESKVLTSDQLMDGGEDEDLKYAKLLQEEEHMKSMDRSRNKRSSTTSAPNKFYIKINEDEIAHDYPLPSYYKNTKDETDELVLFNAGYAVDARNLPCRTLHNWALYNSDLMLISLEFLPMKPCADIDVTYLGQIKEWKIDFGEDMIFVLLRTDMAWYRLGKPSEQYAPWFEPILKTVRIGTSILALLKNETRMAKLSYTDVIKRLCGLEENDQAYISSTFFDVERYVIVHGQIILQFLTECPDEYIKRCPFVTGLASKMQDRHHTKWIIKKKRKMLQKGENLNLRRGKAPKVSKMKAMQATTTRLINRIWGEFYSIYSPEDPLEEIGAEEEFEEVEDVEEEDENEEEDTIQKAIEVQKADTLKKIRGSCKEMEIRWEGEILGETCAGEPLYGQALVGGRKMDVGGAVILEVDDQGETPLIYFVEYMFESSDNSKKLHGKLLQRGSETVLGTAANERELFLTNECLTVQLKDIKGTVSFEIRSRPWGHQYKKEHMAADKLDRARAEERKAKDLPIEYYCKSLYSPEKGGFFSLPRSDMGLGSGFCSSCKIRENEEERSKTKLNDSKTRFLSNGIKYSVGDFVYQIPNYLSKDRGKRRPVFKYGRNVGLRAFVVCQILDIVDLKEPKKGNTTSFEVKVRRFYRPDDVSAEEAYASDIQEVYYSEDTYILPPEAIKGKCEVMKKTDMPLCREYPILDHVYFCDRFYDSSNGCLKKLPYNMMLKFSTIKDDTLLREKKTETGSAMLLKPDEVPKGKRLATLDIFAGCGGLSYGLEKAGVSDTKWAIEYEEPAAQAFKQNHPKTTVFVDNCNVILRISWLRLLINDRAIMEKCGDVDDCISTTEAAELATKLDENQKSTLPLPGQVDFISGGPPCQGFSRLNRFSDGSWSKNQCQMILAFLSFADYFRPKYFLLENVKTFVSFNEGHTFHLTVASLLEMGYQVRFGLLEAGAYGISQPRKRAFIWAAAPNEVLPEWPEPMHVFNNPGFKIPLSQGLHYAAVQSTKFGAPFRSITVRDAIGDLPPIESGESKINKEEMRGSMTVLTDHICKKMNELNLIRCKKIPKTPGADWRDLPDEHVNLSNGIVKNIVPNLLNKAKDHNGYKGLYGRLDWHGNLPTCITNLQPMGLVGMCFHPDQDRIISVRECARSQGFPDSYKFSGNIKDKHRQVGNAVPPPLAFALGRKLKEALHLRNI
What is the function of this protein?
Maintains chromatin CpG methylation that plays a role in genomic imprinting, regulation of embryogenesis and seed viability.  Required for proper patterns of CG DNA methylation in dividing cells (By similarity).  Required during the endosperm development in seeds.
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase 3, DNA methyltransferase 3, DNA methyltransferase III, Protein MATERNAL EFFECT EMBRYO ARREST 57.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSCB_AZOVD
Sequence: MGNASHFALFDLEPDFRLDQDRLAVRYRELVRRVHPDRFAGAPEREQRLALEEAARLNEAYQTLKSPSQRARYLLSLQGEELSQETTVQDPAFLMQQMELREELQELQDSADLAGVARFKRRLVQDQEQLNEGFAACWADPRRRDEAERLARRMQFLDKLFAEVRQLEERLDD
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: BRNP2_MOUSE
Sequence: MRWPCSSWFRGLWPEAAPWAVLLALGVPGWVLAVSATVAAVVPEQHVSSAGQAPLDWLLTDRGPFHRAQEYADFMERYRQGFTTRYRIYREFARWKVNNLALERRDFFSLPLPLAPEFVRNIRLLGRRPNLQQVTENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSRKSETTGGIPVVGGTGNSSAVSLETLHQLAASYFIDRESTLRRLHHIQIATGAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKVQLLGLQVLLPEHLRERFVAAALSYITCSSEGELVCRENDCWCKCSPTFPECNCPDADIQAMEDSLLQIQDSWATHNRQFEESEEFQTLLKRLPSDRFLNSTAISQYWTMDSNLQHRYQQLGASLKVLLKKMHRIVRRLFNLCKRCHRQPRFRLPKERSLSFWWNRIQSLLYCGESTFPGTFLEQSHSCTCPYDQSSCQGPIPCALGEGPACAHCASDNSTRCGSCNPGYVLAQGLCRPEVAESLENFLGLETDLQDLELKYLLQKRDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSLQICLTKNSTLEPVMAIYVNPFGGSHSESWFMPVNEGNFPDWERTNVDAAAQCQNWTITLGNRWKTFFETVHVYLRSRIKSLDDSSNETIYYEPLEMTDPSKNLGYMKINTLQVFGYSLPFDPDAIRDLILQLDYPYTQGSQDSALLQLIELRDRVNQLSPPGKVRLDLFSCLLRHRLKLANNEVGRIQSSLRAFNSKLPNPVEYETGKLCS
What is the function of this protein?
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.
What are the official names of this protein?
BMP/retinoic acid-inducible neural-specific protein 2.
What is the protein family that this protein belongs to?
Belongs to the BRINP family.
What are the subcellular locations of this protein?
Secreted.
Protein: DRE2_VANPO
Sequence: MTLGDRLGLILIHPAVTTVPGLLEAKKLELSKKNYVIGDQFLINKLNDNSVTLEKDKYDLIYYLTPEKVEDIKFPVKLIPVIQSALKTNGSFYGLTEAFKVDALVNGFEIVSVEDNDYHWIKKAGSANANVVQLKTKKKLGNEVKSGKLPTFKSKLPTFKKKDAGNNEQVVKLSVEDVEDDLDDDPEVSNELLSKAKFFNSLSLNQDAEIDENNLIKSTDGDGITMITCGKTNTKKRRACKDCTCGMKELEEEEIDNIRTQQDKVVQFTSEELTEIDFTIEGKLVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPISLSSISDDL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein DRE2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: NUOA_YERPA
Sequence: MRMSTTTEIIAHHWAFAVFLIGAVGLCGLMLLGAYFLGGRAQARAKNVPYESGIDSVGSARMRLSAKFYLVAMFFVIFDVEALYLYAWSISIRESGWIGFIEAAIFILVLLAGLFYLVRIGALDWTPTRSNRRVSKPSTVRYASSHPQDISQELSVAGSQQANESR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SRK2I_ARATH
Sequence: MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDIDSSGEIVYAL
What is the function of this protein?
Together with SRK2D, key component and activator of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as seed germination, Pro accumulation, root growth inhibition, dormancy and seedling growth, and, to a lesser extent, stomatal closure (PubMed:17307925).  In response to ABA, phosphorylates the ESCRT-I complex component FREE1, which is required for ABA-induced FREE1 nuclear import (PubMed:30962512).
What are the official names of this protein?
Serine/threonine-protein kinase SRK2I, OST1-kinase-like 2, Protein ATHPROKIN B, SNF1-related kinase 2.3, SnRK2.3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: MECI_MAMSC
Sequence: MDNKTYEISSAEWEVMNIIWMKKYASANNIIEEIQMQRDWSPKTIRTLITRLYKKGFIDRKKDNKIFQYYSLVEESDIKYKTSKNFINKVYKGGFNSLVLNFVEKEDLSQDEIEELRNILNKK
What is the function of this protein?
Transcriptional repressor that constitutively blocks the transcription of the gene for the penicillin-binding protein MecA.  Binds DNA as a dimer (By similarity).
What are the official names of this protein?
Methicillin resistance regulatory protein MecI.
What is the protein family that this protein belongs to?
Belongs to the BlaI transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBG_CANGA
Sequence: MTGEIITIQVGQCGNHVGKYFWNQLLKEHGIDKDGYSKYNDDLTHIREDDTNPFFKQITNNRYVPRAIMIDLEPAAVTDVQSSFNDLFNPRNTWVSSEGLGAGNSWSTGYDRGVQNQDRIMDIIDRELDSTDNFEGFQLLHSVAGGTGSGLGSSLLEALTDRYSKSFITTYSVFPSKQSEVVVGPYNTVLTLRRLCEDADASIIFDNNALLNLTARTFRDPNTSYEHTNQLISSALSSITNSLRFPSYMYNSMASIFSTLIPTPELHFLTPNFTPFTPDYIIGGQRYKKNTAYDVLLDLLDPFNSLVTQRSDMVTHFNVFSTVIGEVDQNHILRALPKMQQRLNMPSWSTSALNVNIGRRSPYLPPLESRENSVSGLMLSNTSAITSVFERSASAFDKLFYKGAFLNQFESGQLFQNGLDEFVESREVITRMMEEYSNAEQDTYLDDILNEDDIMIGGFDNEGDS
What is the function of this protein?
Tubulin is the major constituent of microtubules.  The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly (By similarity).
What are the official names of this protein?
Tubulin gamma chain, Gamma-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: OGT_MYCLE
Sequence: MIHCRSMDSPIGPLILAGHGSVLTNLQMVDQTYEPSRVGWLPENGAFAEAVSQLDAYFAGELTEFAIELDLCGTEFQQRVWQALLTIPYGETRSYGEIAEQVGAPGAARAVGLANSRNPIAIIVPCHRVIGASGQLIGYGGGLNRKLTLLELEKHQVLTSLTLFD
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_ASHGO
Sequence: MSLSSKLTVKDLSLAGKRVFIRVDFNVPLDGKTITSNQRIVAALPTIKYVLEQGPKAVVLASHLGRPNGERNEKYSLAPVAAELEKLLGQKVNFLDDCVGEHVTAAVNGAAAGSVFLLENLRFHIEEEGSRKVDGEKVKASAEDVQKFRQGLMSLADVYVNDAFGTAHRAHSSMVGFELPERAGGFLLSRELEYFSKALENPTRPFLAILGGAKVADKIQLIDNLLDKVDSIVIGGGMAFTFKKVLENMEIGNSIYDKAGAEIVPKLAEKAKKNGVKIVLPVDFVIGDDFSQDANTKIVSASEGIPSGWEGLDCGPESRKLFSETIASAKTIVWNGPPGVFEIPKFSEGTQAMLAAAVKASEAGSTVIIGGGDTATVAKKYGVVEKISHVSTGGGASLELLEGKDLPGVTFLSSKQ
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXI3_HUMAN
Sequence: MALYCGDNFGVYSQPGLPPPAATAAAPGAPPAARAPYGLADYAAPPAAAANPYLWLNGPGVGGPPSAAAAAAAAYLGAPPPPPPPGAAAGPFLQPPPAAGTFGCSQRPFAQPAPAAPASPAAPAGPGELGWLSMASREDLMKMVRPPYSYSALIAMAIQSAPERKLTLSHIYQFVADSFPFYQRSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRRSEASNGSTVAAGTSKSEEGLSSGLGSGVGGKPEEESPSTLLRPSHSPEPPEGTKSTASSPGGPMLTSTPCLNTFFSSLSSLSVSSSVSTQRALPGSRHLGIQGAQLPSSGVFSPTSISEASADTLQLSNSTSNSTGQRSSYYSPFPASTSGGQSSPFSSPFHNFSMVNSLIYPREGSEV
What is the function of this protein?
Possible transcriptional factor.
What are the official names of this protein?
Forkhead box protein I3.
What are the subcellular locations of this protein?
Nucleus.
Protein: HEM2_CHLMU
Sequence: MTRLPLLKRPRRNRKSAAIRSMIRETNMVSSDLIWPIFLKEGSGIREEIPSMPGVYRWSLDTISRELERLCLIGLKAVILFPVIEDQKKDQFGAYASHPYNIVCRGIQEIKKSFPQLCVISDIALDPFTTSGHDGIFYNNEVLNDESVRVYGDIATLHAEMGADIVAPSDMMDGRVRHIREKMDQMGFVNTGILSYSAKYASYLYGPFRDALSSHPQSGDKRQYQMDPANVREALLECRLDEEEGADMVMIKPAGFYLDVIMKAQECTHLPVVAYQVSGEYSMIMAASLHGWLSKEGAISESLLAIKRAGATAIISYATPWVLEWLARDALPF
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALAD, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: HDT1_SOYBN
Sequence: MEFWGVEVKVGQTVTVDPMDPVDSYIHISQVALGEAKKDKPNEPVVLYLKVGEQKIVLGTLSRDGIPHLSLDLVLDSDSELSHTSKSASVFFCGYKVLTGNDNASDFSDSSEEDEELALEGQDNGKPELKAEGAKVTKPSKSIPKIGAPAKAADPKKDEDDDSDDESDDDLAGEDESGSSDEMDDDSNSEEESDGDDEETPAKKVDQGKKRPNESAAKTPISAKKAKTATPEKTDGKKSVHVATPHPSKKGGKTPNSTKGQTPNSAGQLSCASCKKSFTNEAGLQQHKKAKHGGQ
What is the function of this protein?
Mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).
What are the official names of this protein?
Histone deacetylase HDT1, Histone deacetylase 2a, HD2a, Nucleolar histone deacetylase HD2-p39.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase HD2 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: BMX_MOUSE
Sequence: MESKSILEELLLKKSQQKKKMSPNNYKERLFVLTKTSLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRCQWLKALQKEIRGNPHLLIKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYADLHIAISDEKHRAPTFPERLLKIPRAVPVLKMDASSSGAILPQYDSYSKKSCGSQPTSNIRYIPREDCPDWWQVRKLKSEEDIACSNQLERNIASHSTSKMSWGFPESSSSEEEENLHAYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQMGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPVSVALGSGIWELKREEITLLKELGNGQFGVVQLGQWKGQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQIMYSCWHELPEKRPTFQQLLSAIEPLREQDKP
What is the function of this protein?
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis.  Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins.  Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation.  Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility.  Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis.  Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation.  Also involved in interleukin-6 (IL6) induced differentiation.  Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts.  May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1.  May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
What are the official names of this protein?
Cytoplasmic tyrosine-protein kinase BMX, Bone marrow tyrosine kinase gene in chromosome X protein homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
Protein: RUVC_CAMHC
Sequence: MKILGIDPGTRNMGYAVLEKNVNKISLIEAGLIKMKPENLQFQLTQMCEAIDQIFEFHKIDEVAIESMFYAYNPQSVLKLAQFRGGLSLKILQVFGNFAEYTPLQIKKNVTGKAKADKTQVAFMVKKMLGISKDIKPLDVTDAIAIAITHAHNLRGVK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: CRK12_ARATH
Sequence: MPLLFLWFFLTSTSLVSALQTLPCINTTYFIPNSTYDTNRRVILSLLPSNVTSHFGFFNGSIGQAPNRVYAVGMCLPGTEEESCIGCLLSASNTLLETCLTEENALIWIANRTICMIRYSDTSFVGSFELEPHREFLSIHGYKTNETEFNTVWSRLTQRMVQEASSSTDATWSGAKYYTADVAALPDSQTLYAMMQCTPDLSPAECNLCLTESVVNYQSCCLGRQGGSIVRLSCAFRAELYPFGGAFTVMTARPLSQPPPSLIKKDSGKFSTETIAAIVVPIIVVAIIFLVLLVLSRLFARRRKSYQEIDLDQSGITTLHFQQLDFKTIEVATENFAKTNKLGQGGFGEVYKGTLVNGTEVAVKRLSKTSEQGAQEFKNEVVLVAKLQHRNLVKLLGYCLEPEEKILVYEFVPNKSLDYFLFDPTKQGQLDWTKRYNIIGGITRGILYLHQDSRLTIIHRDLKASNILLDADMIPKIADFGMARISGIDQSVANTKRIAGTFGYMPPEYVIHGQFSMKSDVYSFGVLILEIICGKKNRSFYQADTKAENLVTYVWRLWTNGSPLELVDLTISENCQTEEVIRCIHIALLCVQEDPKDRPNLSTIMMMLTNSSLILSVPQPPGFFVPQNKERDSFLSSQFTMGCTSQTKNDVTITNLDPR
What are the official names of this protein?
Putative cysteine-rich receptor-like protein kinase 12, Cysteine-rich RLK12.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL16_FINM2
Sequence: MLMPKRVKYRRVHRGRMKGKALKGNTLTYGDYGIQALGSCWLTANQIEAARRAMTRYIKRGGNIWIKVFPDKPVSKKPIGIRMGSGKGAPEYWVAVIKPGRVLFEMAGVPEDVAREAMRLAQHKLPIKTKFIAREEFGEKDGEADEN
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: YOJO_ECOLI
Sequence: MHTPIGVKPVAGSKEWREAWQKRAFAHISNGYKYIYIAIDSPEIFLLVCSLIRI
What are the official names of this protein?
Protein YojO.
What is the protein family that this protein belongs to?
Belongs to the YojO family.
Protein: MCSP_HUMAN
Sequence: MCDQTKHSKCCPAKGNQCCPPQQNQCCQSKGNQCCPPKQNQCCQPKGSQCCPPKHNHCCQPKPPCCIQARCCGLETKPEVSPLNMESEPNSPQTQDKGCQTQQQPHSPQNESRPSK
What is the function of this protein?
Involved in sperm motility.  Its absence is associated with genetic background dependent male infertility.  Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).
What are the official names of this protein?
Sperm mitochondrial-associated cysteine-rich protein.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis.
Protein: EFP_CUPTR
Sequence: MKIAQELRVGNVFMIGGDPMVVQKAEYNKSGRNAAVVKMKYKNLLTDAPGESVFKADDKFEVVVLERRECTYSYFADPMYVFMDADYNQYEVEKDSMGDSLNYLEDGMNVEVVFYNDKAISVEMPTTLVREIVYTEPAVKGDTSSGKVLKGAKINTGFELQVPLFCNIGDKIEIDTRTGEYRSRAN
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_RICCN
Sequence: MADLAKIEEQLSSLTLMQAAELVKMLEEKWGVSAAAPVAVAAVGAAAPAAEAVAEKTEFEVVLTAAGDKKVEVIKVVKDITGLGLIEAKKLVDEAPKPIKSNVKKAEADEIKGKLEAAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: ZSCA4_PONPY
Sequence: MALDLRTIFQCEPSENNLGSENSEFRQSQGPAVQREEGISEFSRMVLNSFQDSNNSYARQELQRLYRIFHSWLQPEKHSKDEIISLLVLEQFMIGGHCNDKASVKEKWKSSGKNLERFMEDLTDDSINPPALVHVHMQGQEALFSEDMPLKDVIVHLTKQVSAQTPREANMGTPSQTSQDTSLETGEGCEDEQDGCNSSLKTTQVNENITNQGNQIVSLIIIQEENGPRSEEGGVSSDNPNNSKRAELVTARSQEGSINGITFQGVPMEMGAGCISQPEQSSPESALTHQSNEGNSTCEVHQKGSHGVRKSYKCEECPKVFKYLCHLLAHQRRHRNERPFVCPECQKGFFQISDLRVHQIIHTGKKPFTCSMCEKSFSHKTNLRSHERIHTGEKPYTCPFCKTSYRQSSTYHRHMRTHEKITPPSVPSTPEAS
What is the function of this protein?
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency.  Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation.  Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
What are the official names of this protein?
Zinc finger and SCAN domain-containing protein 4.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: RL21_RHOBA
Sequence: MYAIFVDGGRQYRVEPGMELDVDYRDIAAGENLKFETVLAVGAEDGLKLGAPTLDGVSVSASVLGMSQDKKIYIQKFRRRKHSKKRTGHRQKNTRIRIEEIAGV
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: TUSB_SALNS
Sequence: MLHTLPHCASSVDFPALLRLLKEGDALLLLQDGVTVAIEGNRFLESLRDAPITVYALKEDIDARGLGGQISDSVVRVDYTEFVRLTVKYANQMAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.