PharMolix/UniProtQA huggingface dataset:
Protein: CAS1A_METHJ
Sequence: MNSVLITGAGYRIRKRGDVLTIETGKDSDTAEPPRTLSPLGLDLLAIAGDHSISTAAVRLVTSHGGAIALMDGLGNPFGHFLPLGRSALIEQYEAQASAPEERRLEIARSICTGALENKRTLLSNLERIRGFDLSREIRLVEDAQDKALECQSLDSLRGVEGSGAHAYFQGFSLAFDEEWGFLGRSQNPATDPVNSLLSYGYGMLYIQARQALVLSGYSPYYGAYHETYKKQEALVYDLVEEFRQPVVDRTVVTFLAKHMATPDDFTYPDEGGCMIGTMAKKKYAAAVLTRIHGKVKYEEQTFQDIFKRQAERIGKALTEGDEYVPYRYRT
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Acts as a dsDNA endonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endonuclease Cas1 1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endonuclease Cas1 family.
Protein: BSHC_BACAH
Sequence: MEIKEISVPQQGVVADYMNGKKEIQSCFDYMLTEDAFKQRVQDLREREFFRQDLVTHLLEYNTKLQAGEATIQNVKALGDENTYVVIAGQQAGLLTGPLYTIHKIISVLQLAKEKEESLGVKVVPVFWIAGEDHDMDEINHTFVTKNKKIKKTIFHDRNPKKASASESELSLEDCRKWIEEIFKTYPETNFTKDVLQFVDDSLRKSNTYVDFFGHLIMKMFVNSGLILVDSHHPELRKLEVPFFKQIVSKYKEVQEGLHNQQEVIKELGYKPIIETKSNAVHIFMEIDNERVLLEDNQGKFVGKDGTYSFSYEELIEEMERSPERFSNNVVTRPLMQEYVFPTLAFIGGPGELAYWSELQQVFHTIGFRMPPVVPRITITYIERDIATDLHDLQLQERDPFLNNVDKLRENWLSNQIEEPIDDRFVEAKKEIMNIHTSLQQFVKEIDPGLSAFAGKNEFKINEQIELLERMLKRNVEKKHEVELNKFRRIQFALRPLGAPQERVWNVCYYLNQFGLDFVDHVMEKTFSWNGKHHVIKL
What is the function of this protein?
Involved in bacillithiol (BSH) biosynthesis.  May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.
What are the official names of this protein?
Putative cysteine ligase BshC.
What is the protein family that this protein belongs to?
Belongs to the BshC family.
Protein: GCH4_STAA2
Sequence: MTEFDLSTREGRWKHFGSVDPIEGTKPTTKNEMTDLQSTHKDFLFEIEEVGIKNLVYPVLVDQYQTAGTFSFSTSLTKDEKGINMSRIIESVEKHYDNGIELEFNTLYQVLRTLQTNMKQNAAGVDVSGKWFFDRYSPTTNIKAVGNADVTYGLAIDGDKVTRKELTIEATVTTLCPCSKEISEYSAHNQRGVVTVKTYINKDQNIVDDYKNKILDAMEANASSILYPILKRPDEKRVTERAYENPRFVEDLIRLIAADLVEFDWLDGFDIECRNEESIHQHDAFAKLKYRK
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: NUP93_DANRE
Sequence: MDTEGFGELLQQAEQLAAETEAVSELPHVERNLQEIQQAGERLRSRTLTRTSQDTADVKASILLGSRGLDIFHISQRLESLSAATTFEPLEPVKDTDIQGFLKNERDNALLSAIEESRRRTFLLAEEYHRDSMLVQWEQVKQRVLHTLLGAGEDALDFSQEVEPSFVSEVGVPGRSALDSVEVAYSRQIYVFNEKIVNGHLQPNLGDLCASVAESLDDKNVSEMWLMVKQMTDVLLVPAKDTLKSRVSVDMQMAFVRQALQFLENSYKNYTLVTVFGNLHQAQLGGVPGTYQLVCSFLNIKLPTPLPGRQDGEVEGHPVWALIYFCLRCGDLSAAMQVVNKAQHQLGDFKIWFQEYMNSPDRRLSPATENKLRLHYRRVLRNSADPYKRAVYCLIGKCDIGDNHGEVADKTEDYLWLKLNQVCFDEDGSSSPQDRMTLAQLQKQLLEDYGESHFSASHQPFLYFQVLFLTAQFEAAIAFLFRVERLRSHAVHVALVLYELKLLLKSSGQSAQLLSQEAGDPPMVRRLNFIRLLMLYTRKFESTDPREALQYFYFLRNEKDSQGENMFMRCVSELVIESREFDMLLGRLEKDGSRKPGVIDKFAGDTRAIITKVASEAENKGLFEEAVKLYELAKNADKVLELMNKLLSPVIAQVSEPQSNKERLKNMAVAIAERYRANGVAGEKSVDNTFYLLLDLMTFFDEYHAGHIDRAYDVIERLKLVPLSQDSVEERVAAFRNFSDEVRHNLSEVLLATMNILFTQYKRLKGAAAGTPGRPQRTLEDRDMLLRIQARALITFAGMIPYRMAGDTNARLVQMEVLMN
What is the function of this protein?
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
What are the official names of this protein?
Nuclear pore complex protein Nup93, 93 kDa nucleoporin, Dead eye protein, Nucleoporin Nup93.
What is the protein family that this protein belongs to?
Belongs to the nucleoporin interacting component (NIC) family.
What are the subcellular locations of this protein?
Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex. Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.
Protein: CARB_NEIMB
Sequence: MPKRTDLKSILIIGAGPIVIGQACEFDYSGAQACKALREEGYKVILVNSNPATIMTDPEMADVTYIEPIMWQTVEKIIAKERPDAILPTMGGQTALNCALDLARNGVLAKYNVELIGATEDAIDKAEDRGRFKEAMEKIGLSCPKSFVCHTMNEALAAQEQVGFPTLIRPSFTMGGSGGGIAYNKDEFLAICERGFDASPTHELLIEQSVLGWKEYEMEVVRDKNDNCIIICSIENFDPMGVHTGDSITVAPAQTLTDKEYQIMRNASLAVLREIGVDTGGSNVQFAVNPANGEMIVIEMNPRVSRSSALASKATGFPIAKVAAKLAVGFTLDELRNDITGGKTPASFEPSIDYVVTKIPRFAFEKFPAADDRLTTQMKSVGEVMAMGRTIQESFQKALRGLETGLCGFNPRSEDKAEIRRELANPGPERMLFVADAFRAGFTLEEIHEICAIDPWFLAQIEDLMKEEKAVSDGILSDLDFAALRRLKRKGFSDKRLAQLLNVSEKEVREHRYALKLHPVYKRVDTCAAEFATETAYLYSTYEEECESRPSDRKKVMILGGGPNRIGQGIEFDYCCVHAALALRESGFETIMVNCNPETVSTDFDTSDRLYFEPLTLEDVLEIVRTENPWGVIVHYGGQTPLKLANALVENGVNIIGTSADSIDAAEDRERFQKVLNDLGLRQPPNRIAHNEEEALVKAEEIGYPLVVRPSYVLGGRAMQVVHSAEELQKYMREAVQVSEDSPVLLDFFLNNAIEVDVDCVSDGKDVVIGGIMQHVEQAGIHSGDSGCSLPPYSLSEEIQDEIRRQTKAMAYALGVVGLMNVQFAVQDGVVFVLEVNPRASRTVPFVSKATGVPLAKVGARCMAGISLKEQGVEKEVVPDFYAVKEAVFPFIKFPGVDTILGPEMRSTGEVMGVGASFGEAYYKAQLGAGERLNPTGKIFLSVREEDKERVIKTAKNFQVLGYGICATRGTAQYLTEHGLIVQTINKVPEGRPHIGDALKNGEIALVVNTVSSDPQSVSDSHIIRQSALQQRVPQYTTTAGGEAMSEGAKSRDHLGVYSVQELHGRLKNRN
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: KKX13_HETSP
Sequence: GFGCYRSCWKAGHDEETCKKECS
What is the function of this protein?
Shows very weak blocking activity on voltage-gated potassium channels Kv10. 1/KCNH1/EAG1 (6. 2% inhibition by 40 uM of the toxin) (PubMed:27578329).  Has no effect on the other voltage-gated potassium channels tested (PubMed:15670585).
What are the official names of this protein?
Potassium channel toxin kappa-KTx 1.3, Kappa-hefutoxin 3.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ITR1_TRIKI
Sequence: MAAFVESARAGAGADEVIQLVSDGVNEYSEKMMEGVVACPRILMPCKVNDDCLRGCKCLSNGYCG
What is the function of this protein?
Inhibits trypsin.
What are the official names of this protein?
Trypsin inhibitor 1, TTII, Trypsin inhibitor I.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I7 (squash-type serine protease inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: HPS5_PITAZ
Sequence: FRPALIVRTKGTRL
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Hyposin-H5, HPS-H5, Hyposin-4, Hyposin-HA4.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Hyposin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: IIGP5_HUMAN
Sequence: MATSKLPVVPGEEENTILMAKERLEALRTAFESGDLPQAASHLQELLASTESIRLEVGVTGESGAGKSSLINALRGLEAEDPGAALTGVMETTMQPSPYPHPQFPDVTLWDLPGAGSPGCPADKYLKQVDFSRYDFFLLVSPRRCGAVETRLAAEILCQGKKFYFVRTKVDEDLAATRTQRPSGFREAAVLQEIRDHCAERLREAGVADPRIFLVSNLSPARYDFPTLVSTWEHDLPSHRRHAGLLSLPDISLEALQKKKAMLQEQVLKTALVLGVIQALPVPGLAAAYDDALLIHSLRGYHRSFGLDDDSLAKLAEQVGKQAGDLRSVIRSPLANEVSPETVLRLYSQSSDGAMRVARAFERGIPVFGTLVAGGISFGAVYTMLQGCLNEMAEDAQRVRIKALEDDEPQPEVSLEVASDNGVEKGGSGEGGGEEAPLSTCRKLGLLLKYILDSWKKHDSEEK
What are the official names of this protein?
Interferon-inducible GTPase 5, Immunity-related GTPase cinema 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
Protein: TGB3_CMVSI
Sequence: MLGTRNIPTTSGLPLPPPSSSLSAYIFPTILAIIFAVFALVAIHITTPEPFCTIHIDGASITITNCPDPAAILNKVAIGPWRGLSYHNNLK
What is the function of this protein?
Plays a role in viral cell-to-cell propagation, by facilitating genome transport to neighboring plant cells through plasmosdesmata.  May induce the formation of granular vesicles derived from the Endoplasmic reticulum, which align on actin filaments (By similarity).
What are the official names of this protein?
Movement protein TGBp3, 9.7 kDa protein, Triple gene block 3 protein, TGBp3.
What is the protein family that this protein belongs to?
Belongs to the Tymovirales TGBp3 protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane.
Protein: Y3793_PSEMY
Sequence: MTDSDVQPPKIEFPCERYPIKVIGTAGEGFSDLVIEVIQRHAPDLDASTLVMRDSRNGNFLSVQVLITATSVEQLQAIHVDLRATGRVHMVL
What are the official names of this protein?
UPF0250 protein Pmen_3793.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: VMA21_ASPCL
Sequence: MAGRHSQEKSYAEAAAAPAPEKPDSSDVTPAVPADVIYKLLGFTAAMIVGPIGMYFVTVDFGASSTVAGVTAAVTANVILFTYIYVAWLEDKEDREVAAKRKEKKAQ
What is the function of this protein?
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
What are the official names of this protein?
Vacuolar ATPase assembly integral membrane protein vma21.
What is the protein family that this protein belongs to?
Belongs to the VMA21 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Protein: TYSY_STAAE
Sequence: MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYKGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUS_ECOHS
Sequence: MARYDLVDRLNTTFRQMEQELAAFAAHLEQHKLLVARVFSLPEVKKEDEHNPLNRIEVKQHLGNDAQSLALRHFRHLFIQQQSENRSSKAAVRLPGVLCYQVDNLSQAALVSHIQHINKLKTTFEHIVTVESELPTAARFEWVHRHLPGLITLNAYRTLTVLHDPATLRFGWANKHIIKNLHRDEVLAQLEKSLKSPRSVAPWTREEWQRKLEREYQDIAALPQNAKLKIKRPVKVQPIARVWYKGDQKQVQHACPTPLIALINRDNGAGVPDVGELLNYDADNVQHRYKPQAQPLRLIIPRLHLYVAD
What is the function of this protein?
Trans-acting protein required for termination of DNA replication.  Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks.  The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
What are the official names of this protein?
DNA replication terminus site-binding protein, Ter-binding protein.
What is the protein family that this protein belongs to?
Belongs to the Tus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_HYPNA
Sequence: MAVPKSKKSKSRTRMRRSHDRLAMNTYIEDATSGELRRPHHIDLKTGMYRGKQILEPTDDI
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: CF206_TETTS
Sequence: MNQLEEIVKYVIYKCRENNHPVTETLAAFVTQTIYNPKTDRFYLEDKLTASQVDELKATVLQKLSQIDKPNMKTIQMQISYDSAYIESEIQRQERIKNQSIETGKLTDEVVSLEIKNAKDFEGLTVLFKKIFNFLLYKNKELMYDGTNKTGNQDSENQATQFNIEKEVAAGLESVIPRAALGPFVSLNPSEKVTQLVELSNLVIGIRLFNKWIQKGGIGLVPFQDLLEYEGRDLIERIRQEAFEVIENCDNYTIFFQNVGPGKIKISDEQFKQYKDELTFLRQYLSYILSIQEDVDISENSVDSNQTRYLKEIKDLETLLKQKSSAPKEQVYPKFATLAQAYIQLLEEKKLCLTRVKLFELLQEMRKGFKLTLPRNLILTAKNISQDPSNEEQVEIEYSEDCGIERLLPKNTPDFMQTPLDYLGFCLWSIVKRDGLLLPGKPALGVFRYKDKNCVFSDEKSINEFLSDPQQFIQGVINQCRKNPELIHLLRMDDSFKNVNLNIYVSGQEGGHQLSNKLMVDKGIETPLHFVEKRLDPNYCWNEWELRKKALQMANIRKRQTKACQTILSNFKVDSEAQTYLPKDNETNTGKTEWDIRKFAIEQAKKKGIIAGTDRAPYPIHPRNYITGLRDKDTN
What is the function of this protein?
May regulate cilium motility through its role in the assembly of the axonemal RS2 radial spoke.
What are the official names of this protein?
Cilia- and flagella-associated protein 206, Flagella-associated protein 206.
What is the protein family that this protein belongs to?
Belongs to the CFAP206 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: YO21_ADEG1
Sequence: MCTGSTGSLIPSVSDSANSVRRGNLSLCSVLLSWLICAMCLWNDARESLVNVRIANYVFDFAVLWTLLARVLGPPGRPVLQQHHPVQLPVPTEPSVFVKLCNQRVRL
What are the official names of this protein?
Uncharacterized protein ORF21.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: RS13_BORA1
Sequence: MARIAGINIPPQQHAEIGLTAIFGVGRTRARKICEAAGVPVTKKVKDLTDAELERIREHLGVFTVEGDLRREVQLSIKRLIDLGTYRGMRHKRGLPVRGQRTRTNARTRKGPRRAAASLKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: DER_NEIMF
Sequence: MKPTIALVGRPNVGKSTLFNRLTRTKDALVHDLPGLTRDRHYGHGKVGSKPYLVIDTGGFEPVVDSGILHEMAKQTLQAVDEADAVVFLVDGRTGLTPQDKIIADRLRQSPRPVYLAVNKGEGGNRAVLAAEFYELALGDPYVISGAHGDGVYYLIEDILETFPEPEAEEADAKHPVFAVIGRPNVGKSTLVNAILGEERVIAFDMAGTTRDSIHIDFEREGKPFTIIDTAGVRRRGKVDEAVEKFSVIKAMQAVEAANVAVLVLDAQQDIADQDATIAGFALEAGRALVVAVNKWDGISEERREQVKRDINRKLYFLDFAKFHFISALKERGIDGLFDSIQAAYNAAMIKMPTPKITRVLQSAIERQQPPRAGLVRPKMRYAHQGGMNPPVIVVHGNSLHAISDSYTRYLTQTFRKAFNLQGTPLRIQYNVSENPYENAEDKPKKKPLRRVSLSNRIEKREGRKEEKNRFKKKTKVSVKKQFSK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: RECA_STRSL
Sequence: AYARALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAAFVPRAEIDGDSGDSHVGLQARMMSQAMRKLSASINKTKTIAIFINQLREKVGIMFGN
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity).
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_GEOSL
Sequence: MLNELILTAVAYIVGSIPTGLLLARASGVDIRATGSGNIGATNVYRTLGRTVGIATLLGDCLKGLVPVLVARKLGFADPWVAAVGLAAFLGHVYTIFLGFKGGKGVATALGVFLGVSPLSVLGALALFIGIVATTRYISLGSIIAAAAMPLFVAAVERRPLLVGMTLVIAVIVIVKHRENIRRLREGTENRFKA
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SOCS3_MOUSE
Sequence: MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGTPSFSLPPTEPSSEVPEQPPAQALPGSTPKRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
What is the function of this protein?
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.  SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway.  Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors (PubMed:10821852, PubMed:12754505, PubMed:9889194).  Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling (PubMed:12754505, PubMed:9889194).  Suppresses fetal liver erythropoiesis (PubMed:10490101).  Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (PubMed:12847520).  Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Suppressor of cytokine signaling 3, SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, Protein EF-10.
Protein: SYN_STRSV
Sequence: MSKKIVTIIDVKNYVGQEVTIGAWVANKSGKGKIAFLQLRDGSAFFQGVAFKPNFIEKFGEEEGLAKFDTIKKLSQETSVYVTGVVKEDERSKFGYELDITDIEIIGESNDYPITPKEHGTDFLMDNRHLWLRSRKQVAMMQIRNAIIYATYEFFDKNGFMKFDSPILSGNAAEDSTELFETDYFGTPAYLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSYLTHDESLDLQEAYVKALIQGVLDRAPQALETLERDVELLKRYIAEPFKRVSYDEAIDLLQAHENDEDADYEHLEHGDDFGSPHETWISNHFGVPTFVVNYPAAIKAFYMKPVPGNPDRVLCADLLAPEGYGEIIGGSMREEDYDALVAKMNDLGMDTTEYEFYLDLRKYGTVPHGGFGIGIERMVTFVAGTKHIREAIPFPRMLHRIKP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_RHOCS
Sequence: MTRRLFGTDGIRGTANTDPMTAEMALKVAMATAAQFRRGSHRHVVVIAKDTRLSGYMLEPALTAGFVSMGMDVVLVGPLPTPAVAMLTRSLRADLGVMVSASHNPFHDNGIKLFGPDGYKLSDEMEAAIEARIAADGAAGGPAADLAGPRDLGRASRLEDAPGRYIEQVKASFPRGLRLDGLKIVVDCANGAAYRVAPKVLWELGAEVVPLAVGPDGFNINRDCGATAPAAMRAAVLEHKAHLGLALDGDADRLILADESGTQIDGDQIMALIGRSWAEDGRLKGGGVVATVMSNLGLELFLRDRGLTLVRTPVGDRYVVEHMREYGFNVGGEQSGHIVLSDFATTGDGLLAALQVLAEIQRTGRPASEVLRVFQPLPQLLRNVRFDPAGGVRPLEAAGVQAAIRAGEARLGGRGRVLIRKSGTEPLIRVMAEGEDEGLVASVVADIVAAVEAATVPRAAGEAATVTQVQPAE
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: TATA_RHOE4
Sequence: MGAMQPMHWLIVAVVVVILFGSKKLPDAARGLGRSLRIFKSEVKEMQNDDAAPASAPVAQPAPAQLPTANTAVVANGAAAPVAQPTEVKPL
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RR15_LEMMI
Sequence: MVKNSFISIISQEQEEKEENKGSVEFQVFSFTNKIRRLTSHLGLHKKDFSSQRGLRIILGKRQRLLAYLSKKNRVRYKKLIGQLDIREPKTR
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FAKD4_XENTR
Sequence: MAARLVQRCSRLLAASTAYAPATHTHIHECMKVCHPAQPVLPCSSLHSSSLCRHKDKALTKEQTVSSVPEHGKFESVLESLSSVEELLQLGVDREISGNQAAMIITQVSKVLMESKAQGGSVVQDERFQQLLVQAHNQISTIWNGNLVSLLKRLYILGIREDNKQLQAVENEVRWRLRRLSFKSLVQLSDLYVTFTRSPEQKHLVSDLVKNLELRWTEIEDAKSVVTLMTRVGFISKALMEKLEDKALEYAEQFTPDEMRKVALALAAQNRRTVPLLRALSYHLVQRHIGLSPAVVVDLAFAYGKLNFHQTQVFQKMASDLLPKVPEMSANDIARCVKSFAYLKWSNLPLFEAFAQASIDQSEKFTVPQLCNLVLAFGRLNFQPSKREEFYSMMHQKLHAELDLLDPYLLVDIVWSLCVLRQVDSSYISKVLEPGLYSRFFTDSSPRSANYRLKLAHINATALLEHPEYTGPHLPNESISTTHAVTANRKLSPLQSGLQEVLRELFPVEGTCRCGVNTVYGWYIDGEVVLDSDNKPLSLMDLEAPHLPHSQGKKPLPEGTRRFAFVAWDFPNFNSRSKDLLGRFVLTRRHLQAAGFLVVEVPYYEWLDLKSEWQKSAYLKDKINKVVAEEMAR
What is the function of this protein?
Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species.  May play a role in cell cycle progression.
What are the official names of this protein?
FAST kinase domain-containing protein 4, Protein TBRG4, Transforming growth factor beta regulator 4.
What is the protein family that this protein belongs to?
Belongs to the FAST kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: MURD_CYAP4
Sequence: MPHAHIIGLGQSGIAAARLLRREGWQVTISDRNSTPTLVEQQQRLDQEGIDVLLAHNFELDRDSHPPDLVVVSPGVPWQGAGLVQARAAGIETIGEIELAWRHLQQFPWVGITGTNGKTTTTALVAAMFQTAGLKAIACGNIGYSVCDLVLSEQAIDWVIAEISSYQLESLPRLAPKIAVWTTFTPDHLERHGTLECYRETKAVLLQQAEYKVLNGDDPYLRQELSDRWPEVWWTSCNGRAALPHGIERGIYLEEGWVKVQEQPIVPVSSWKMPGHHNLQNLLLAVAVAHLGGIPVAAIAEAVNNFGGVPHRLEPICTWSGIQFINDSKATNYDAAETGLVAVPAPVILIAGGQAKQGDDRRWLEMIQTKAAAVLLIGAAANLFAQRLQEVGYDRYEIVETMANAVPRAAELAKKYSANIVLLSPACASFDQYKSFEQRGDDFRQLCLSRFAK
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETN_SYNR3
Sequence: MLISLGWAALAATFTFSIAMVVWGRNGDGSINF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: CCD22_DROER
Sequence: MDEVDKIIMHQLHQVDAAIEPTEELSGFTPEQVVRAVSGCLAEISPDLQLPRTLPGGAMAQRFGVASSLAQGCKDSGYRGDIGYQTFLYPNAVELRRLLMFLIEQLPRERQSAEDGASKSQTLSHRQLLERKIRKELAQQLKTPWVPQFARSVGNRKLLGCSSLGIEFRPNINLNIPSANPEERSKEQQQYLDQQAPNLFQQTASSSADLIASVLHKNELDRWDQTLSDSTLLFVDSEEPAPPPISTVKPDASAEEEASPIQELSDQVEELRVQCETLLAERKAHAVAIAALKQRETKASEEISRIQPTLKLHERTSLVLADSEENLTKLEALLKSTQSKRITLTQQWQDYRKPLLESLEKLKTAKEAQEVQGIRNNIEQLEQELLAKTQQHNELNATLRNASQSLAPRKEYTRRIHEFIGNIRKQRADIYKVLDDTRQLQKQLNVVGAQLQRQFNYTDDLLFQSAKHDLHAKRAYKLLAQLHANCNELVECVSLTGNVTKQIRELEVQIDGEKLKNVLTSLQQITGDIQKFEQHIQELQEQIRTVEQPNAGS
What are the official names of this protein?
Coiled-coil domain-containing protein 22 homolog.
What is the protein family that this protein belongs to?
Belongs to the CCDC22 family.