PharMolix/UniProtQA huggingface dataset:
Protein: END4_BIFLD
Sequence: MMELYIGSHLSTAGGWNALLERSHEEGGTAFAFFPRSPYGKRSKALDPAGAAAFGARLKAEGYGPLVVHAPYVYNLAGKDEAKRTFAIEALAEDIELLTAIREAGQEVYINIHPGAHVGQGTETGCRLISEGLNQVFERTTGVMVLLETMAGKGTECGRNFEELATIMNGVENKANVGVTFDTCHVLDAGYDLVHDYDGVMRQLDEAIGLAEVKAIHVNDSQFGLGSHKDRHANIGQGQLGIPFFTRLVNDPTMAKLPMILETKEQTPTTHRDEIALLRGLVD
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: THIE_STAES
Sequence: MFDSKQLSVYFICGTQDIPKNKSIEQVLKEALEAGITLYQFREKGPNALKGEKKKQLALKLKQLCHSYHVPMIVNDDVQLAQEINADGIHVGQDDMEIQQFASQFKNKIIGLSVGNLKEYQQSDLSKVDYIGVGPMYTTSSKDDASKPVGPSMISQLRLYIHDFPIVAIGGINETNVQPIVDEGADGISVISAITRSTNIDKTVKYFLRYFT
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: MATP_ECOLU
Sequence: MKYQQLENLESGWKWKYLVKKHREGELITRYIEASAAQEAVDVLLSLENEPVLVNGWIDKHMNPELVNRMKQTIRARRKRHFNAEHQHTRKKSIDLEFIVWQRLAGLAQRRGKTLSETIVQLIEDAENKEKYANKMSSLKQDLQALLGKE
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLC4C_HUMAN
Sequence: MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVVPHNFMYSKTVKRLSKLREYQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERCAIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI
What is the function of this protein?
Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448).  Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448).  Binds to serum IgG (PubMed:25995448).  Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283).  May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719).  May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283).
What are the official names of this protein?
C-type lectin domain family 4 member C, Blood dendritic cell antigen 2, BDCA-2, C-type lectin superfamily member 7, Dendritic lectin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: ATPA_BACHK
Sequence: MSIRAEEISALIKQQIENYQSEIEVSDVGTVIQVGDGIARAHGLDNVMAGELVEFSNGVMGLAQNLEENNVGIIILGPYTEIREGDEVRRTGRIMQVPVGKELIGRVVNPLGQPVDGLGPINTTNTRPIESPAPGVMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTAVALDTIINQKDEDMICIYVAIGQKESTVRNVVETLRKHGALEYTIVVTASASQPAPLLYLAPYAGVTMGEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFIETQAGDVSAYIPTNVISITDGQIFLQSDLFFSGVRPAIDAGTSVSRVGGSAQIKAMSKVSGTLRLDLASYRELEAFAQFGSDLDKATQAKLNRGARTVEVLKQGLHKPLRVEKQVIILYALTRGFLDDIPVVDITRFEEEFHAWLDSNATDLLEEIRTTKKLADDDKFAAAINGFKKVFVASE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TATD_DICD3
Sequence: MFDIGVNLTSSQFRSDREQVVARARQAGVTGLLLTGTSVEESEQACLLAAQYPDYCGSTAGVHPHDASGWNDDTADLIHQLAGREQVLAIGECGLDFNRNFSTPQEQEQAFSAQLAIAAERAMPVFLHCRDAHARFMALLTPWLDKLPAAVLHCFTGSGDELDDSLRAGLMIGITGWVCDERRGLALRALLPRIPDDRLLLETDAPYLLPRDLHPKPASRRNEPCFLPHIVRQVAAWRGQDAEWLGRNVDENARRIFRPGQRGE
What is the function of this protein?
3'-5' exonuclease that prefers single-stranded DNA and RNA.  May play a role in the H(2)O(2)-induced DNA damage repair.
What are the official names of this protein?
3'-5' ssDNA/RNA exonuclease TatD, DNase TatD.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUD19_MOUSE
Sequence: MSSSSSWRRAATVMLAAGWTHSSPAGFRLLLLQRAQNQRFLPGAHVFPGGVLDAADSSPDWVRLFAPRHTPPRFGLGPEPPRQPPFPGLSHGDADPAALPDDVALRICAIREAFEEAGVLLLRPRDAAPASQEPSQALSPPAGLAEWRSRVRSDPRCFLQLCAHLDCTPDIWALHDWGGWLTPYGRTIRRFDTTFFLCCLRDIPRVEPDVAEVVGYQWLSPSEATECFLSKEIWLAPPQFYEMRRLENFASLSALYRFCSDRPSEVPEKWLPIILLTSDGTIHLLPGDELYVKDSDFLEKNMSTDKKTEEIVKEGKVLNRVVIHSPYVYEIYMTLPSENKHVYPRNYIVNKRCTAHL
What is the function of this protein?
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (PubMed:16185196, PubMed:29378847).  Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (PubMed:16185196, PubMed:29378847).  Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (PubMed:16185196).  Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673).
What are the official names of this protein?
Acyl-coenzyme A diphosphatase NUDT19, Androgen-regulated protein RP2, Nucleoside diphosphate-linked moiety X motif 19, Nudix motif 19, Renal CoA diphosphohydrolase, Testosterone-regulated RP2 protein, RP2p.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: NTPP_HELPG
Sequence: MELILGSQSSARANLLKEHGIKFEQKALYFDEESLKTTDPREFVYLACKGKLEKAKKLLTNHCVIVVADSVVSVDNRMQRKAKNKQEALEFLKRQNGNEIEVLTCSALISPVLEWLDLSVFRARLKAFDSSEIEKYLESGLWQESAGCVRLEDFHRPYIKSSSKNLSVGLGLNVEGLLGALKLGAKLSLL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMT1_MAIZE
Sequence: MAALAGEDKDVDAFLADCTASGDAAYGAAKAVLERLHAPATRPAARRLLGAVRRRFAASRAAGEDCFRTFHFRIHDVVLDPHVQGFQQMKKLTMMEIPSIFIPEDWSFTFYEGLNRHPDSIFRDKTVAELGCGNGWISIALAEKWCPSKVYGLDINPRAVKIAWINLYLNALDDDGLPIYDGEGKTLLDRVEFYESDLLSYCRDNKIELDRIVGCIPQILNPNPEAMSKIVTENSSEEFLYALSNYCALQGFVEDQFGLGLIARAVEEGISVIKPSGIMVFNMGGRPGQGVCERLFRRRGFRITKLWQTKIMQXADTDISALVEXEKNSRHRFEFFMDLVGBQPICARTAWAYMKSGGHISHALSVYSCQLRQPNQVKKIFEFLKDGFHEVSSSLDLSFDDDSVAEEKIPFLAYLASFLKENKSNPCEPPAGCLNFRKLVAGFMKSYHHIPLTPDNVVVFPSRSVAIENALQLFSPALAIVDEHLTRHLPKQWLTSLAIEGRADCNHADGTVTVIEAPRQSDLLIELIRKLQPQVVVTGMAQFEAITSAAFENLLNVTKDVGSRLFLDISEHLELSSLPSSNGVLKYLAGKTLPSHAAILCGLVKNQVYSDLEVAFAISEDAAVYKALSQTIELLEGHTSLISQHYYGCLFHELLAFQIADRHPQQERQPAEVIPQQMIGFSDPAVSTLKATEFFVPGSAESSIIHMDLDRSFLPVPSAVNASVFESFVRQNITDSETDVRSSIQQLVKDSYGLSAAGCAEIIYGNTSVALFNKLVLCCMQEQGTLLFPLGTNGHYVSAAKFVNASTVTIPTNPSSGFRIEPKVLADTLKNVSRPWVYVCGPTINPTGFLYSDSDIRELLSVCAEYGARVVIDTSFSGLEYETDGWRQWNLAGCLSSLKRSEPSFSVVLLGELSFALTAGGHDFGFVILGDSSLAETFHSFSSLSRPHTTLKYTFKKLLGLKNQKDQHFSDLIVEQKEELKNRANQLIQTLESCGWEAAIGCGGISMLAKPTAYMGKAFKAAGFDGELDASNIREAILRATGLCINSSSWTGIPGYCRFSFALERGEFERAMGCIARFKELVLGGAQMNGA
What is the function of this protein?
Catalyzes the S-methylmethionine (SMM) biosynthesis from adenosyl-L-homocysteine (AdoMet) and methionine.  SMM biosynthesis (by MMT1) and degradation (by HMT-1, HMT-2 and HMT-3) constitute the SMM cycle in plants, which is probably required to achieve short term control of AdoMet level.  Also able to catalyze the selenium-methylmethionine (SeMM) from AdoMet and selenium-methionine (SeMet).  May play a role in phoem sulfur transport; such function is however not essential.
What are the official names of this protein?
Methionine S-methyltransferase, AdoMet:Met S-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y768_OCEIH
Sequence: MAKTKPPVNKNEIYTLTFEDLTHEGNGVAKIEGYPLFVPEVLPDEQAKVKVVKVNKNFGFGKLLELTKTSSHRVEPTCHVHCGGCQLQHMSYDLQLQMKQGQVHNVMKKVAHLDQVPVHPILGMEEPSHYRNKVQIPVGEKNGEVIVGFYQKRSHRILQNQDTCHIQDEAINEVLPFTRQLMNKYGIQAYDEKSHRGQLRHIMVRVGHYTKDIMIVFVTKTSKFPEKDRIIKELTEQFPQVKSIVQNVNDQRTNVVLGKKTKVLWGENYIYDKIGDLTFAISPKSFFQVNPVQTKVLYDKALEYANIDKDDVVIDAYCGIGSISLFLAQKAKKVYGIEVVPEAIEDAKMNAEINGMNNVEFSVGQAEKVMPKWKEQGLDPDVIVVDPPRKGCDVDFLEAMIAMKPKRIVYVSCNPSTLARDLRILEDGGFETKQVQPVDMFPSTNHVECVAELTLKLSN
What are the official names of this protein?
Uncharacterized RNA methyltransferase OB0768.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: MURB_BARBK
Sequence: MNFQPIDGKKLLAWLQPVLSDIKGKITPNVEMRKVTWFRTGGLAELFYQPADEDDLALFFKVLPEFVPVTIVGIGSNLLVRDGGIPGVVIRLSTKSFGQIKQVSSTRFLVGAATADKHLASAALEAEISGFHFYHGIPGGLGGALKMNAGANGVETAERVVEVYALDRKGERHILNLRDMNYAYRHCNIPEGLVFTAALLEGDVGNKDDIRAAMHEVALHRETVQPIREKTGGSTFRNLEDISAWKVIDEAGCRGLQIGGAQMSEMHCNFMINMGEATGYDLEKLGETVRARVFNHSAHHLEWEIQRIGQFEQDRIVLPFDQFH
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD2_PYRFU
Sequence: MITRGRVWKFGDNISTDAITPGRYNLTKDPNELAKIAFIEERPEFSKEVKPGDVVVGGKNFGIGSSRESAALALKAAGVGGVIAKSFGRIFFRNAVNLGLPLLIGNTDPLLDGEIVEVNWRSGEVKKEDGEVLKFKPLDSFLLAIVEEGGIIEYIRRRGDLWIQ
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit 2, Alpha-IPM isomerase 2, IPMI 2, Isopropylmalate isomerase 2.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: ZNF24_PANPA
Sequence: MSAQSVEEDSILIIPTPDEEEKILRVKLEEDPDGEEGSSIPWNHLPDPEIFRQRFRQFGYQDSPGPREAVSQLRELCRLWLRPETHTKEQILELVVLEQFVAILPKELQTWVRDHHPENGEEAVTVLEDLESELDDPGQPVSLRRRKREVLVEDMVSQEEAQGLPSSELDAVENQLKWASWELHSLRHCDDDGRTENGALAPKQELPSAVESHEVPGTLNMGVPQIFKYGETCFPKGRFERKRNPSRKKQHICDECGKHFSQGSALILHQRIHSGEKPYGCVECGKAFSRSSILVQHQRVHTGEKPYKCLECGKAFSQNSGLINHQRIHTGEKPYECVQCGKSYSQSSNLFRHXXXHNAXKLLNVVKV
What is the function of this protein?
Transcription factor required for myelination of differentiated oligodendrocytes.  Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state.  In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle.  Specifically binds to the 5'-TCAT-3' DNA sequence.  Has transcription repressor activity in vitro (By similarity).
What are the official names of this protein?
Zinc finger protein 24.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS14Z_BACP2
Sequence: MAKKSMIAKQQRKQKFKVQEYTRCERCGRPHSVIRKFKLCRICFRELAYKGQIPGVKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: PETM_NOSS1
Sequence: MSGELLNAALLSFGLIFVGWALGALLLKIQGAEE
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 7, Cytochrome b6-f complex subunit PetM, Cytochrome b6-f complex subunit VII.
What is the protein family that this protein belongs to?
Belongs to the PetM family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PRIO_HYLLA
Sequence: MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDQYSSQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: YTFE_ECO57
Sequence: MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLARAAARKELDVEVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHARHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHNTNNVTPPPEACTTWKAMYNGINELIDDLMDHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XYLB_LACPE
Sequence: MSAVVLGIDLGTSAVKVSAIDKQGNVVAQASAKYALQQPHPGYSEQDPEDWVTQTTQAIRELLQQSEVTADQIEGLSYSGQMHGLVLLDESATVLRPAILWNDTRTTSQCRELESQFGDDFIKITGNRPLEGFTLPKLLWVKENEPNIWKRARTFLLPKDYLRYRMTGKLAMDKSDATGTVLLDITTSQWSETLCNQLDIPLTLCPPLIESTAYVGHINQTYAQLSGLSVNTKVFGGAADNAAGAVGAGILSSDKALVSIGTSGVVLKYEDNAQTDYRGVLQYERHAFPGKYYSMGVTLAAGYSLNWFKQTFAPDEDFGTVVASAEQSTIGANGLLFAPYIVGERAPYADATIRGSFIGVDGSHQRADFVRAVLEGIIFSFEDLIKLYQHNGAEFKTIVSIGGGAKSALWLQIQADIFNCKVVSLKNEQGPGMGAAMIAATGLGWFKTLADCAQTFVHYGKAYYPVTAHVAQYQEMYRLYQQIYVQTQPITAGLLEQRKQH
What is the function of this protein?
Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.
What are the official names of this protein?
Xylulose kinase, Xylulokinase.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RL36_LIMF3
Sequence: MKVRPSVKRMCDSCKIVKRRGRVMVICINPKHKQRQGK
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: LACB_STRPC
Sequence: MKIAVGCDHIVTYEKIAVVDYLKSQGHKVIDCGTYDNVRTHYPIFGKKVGEAVASGEAELGVVICGTGVGITNAVNKVPGIRSALVRDMTSAIYSKEELNANVIGFGGKIIGGLLMNDIIDAFLAAEYKPTEENKKWIEKMDSLQHASQDQNNPHFFDEFLEKWDRGEYHD
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacB.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: IL1R1_HUMAN
Sequence: MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHVPLG
What is the function of this protein?
Receptor for IL1A, IL1B and IL1RN (PubMed:2950091).  After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways.  Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.  Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.  Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).
What are the official names of this protein?
Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80.
What is the protein family that this protein belongs to?
Belongs to the interleukin-1 receptor family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cell membrane. Secreted.
Protein: CADH4_CHICK
Sequence: MRTGSRLLLVLLVWGSAAALNGDLTVRPTCKPGFSEEDYTAFVSQNIMEGQKLLKVKFNNCAGNKGVRYETNSLDFKVRADGTMYAVHQVQMASKQLILMVTAWDPQTLGRWEAIVRFLVGEKLQHNGHKPKGRKSGPVDLAQQQSDTLLPWRQHQSAKGLRRQKRDWVIPPINVPENSRGPFPQQLVRIRSDKDKEIHIRYSITGVGADQPPMEVFSIDPVSGRMYVTRPMDREERASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYMVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTTSTYSGEVPENRVEVVVANLTVMDRDQPHSPNWNAIYRIISGDPSGHFTIRTDPVTNEGMVTVVKAVDYEMNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISVTDVNEAPYFPTNHKLIRLEEGVPTGTVLTTFSAVDPDRFMQQAVRYSKLSDPANWLNINATNGQITTAAVLDRESDYIKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNVINITAADADIDPNVGPFVFELPSVPSAVRKNWTITRLNGDYAQLSLRIMYLEAGVYDVPIIVTDSGNPPLYNTSIIKVKVCPCDENGDCTTIGAVAAAGLGTGAIIAILICIIILLTMVLLFVVWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPETMDHVLNKAPGVRRVDERPIGAEPQYPIRPVIPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.  May play an important role in retinal development.
What are the official names of this protein?
Cadherin-4, Retinal cadherin, R-CAD, R-cadherin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: DCUR_ECOL6
Sequence: MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIFNSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVISSAADAVTIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEQDPRRLPKGLTPQTLRTLCQWIDAHQDYEFSTDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRIQAEHYSLLKQYCQ
What is the function of this protein?
Member of the two-component regulatory system DcuR/DcuS.  Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc. ).  Weakly regulates the aerobic C4-dicarboxylate transporter dctA (By similarity).
What are the official names of this protein?
Transcriptional regulatory protein DcuR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OXLA_CROAD
Sequence: MNVFFMFSLLFLAALGSCAHDRNPLEECFRETDYEEFLEIAKNGLTATSNPKRVVIVGAGMAGLSAAYVLAGAGHQVTVLEASERVGGRVRTYRKKDWYANLGPMRLPTKHRIVREYIKKFDLKLNEFSQENENAWYFIKNIRKRVREVKNNPGLLEYPVKPSEEGKSAAQLYVESLRKVVEELRSTNCKYILDKYDTYSTKEYLLKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFGYEKRFDEIVGGMDQLPTSMYEAIKEKVQVHFNARVIEIQQNDREATVTYQTSANEMSSVTADYVIVCTTSRAARRIKFEPPLPPKKAHALRSVHYRSGTKIFLTCTKKFWEDDGIHGGKSTTDLPSRFIYYPNHNFTSGVGVIIAYGIGDDANFFQALDFKDCADIVINDLSLIHELPKEDIQTFCHPSMIQRWSLDKYAMGGITTFTPYQFQHFSEALTAPFKRIYFAGEYTAQFHGWIDSTIKSGLTAARDVNRASENPSGIHLSNDNEF
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:6067195).  Is active on L-Arg, L-Phe, L-Met, and L-Leu and is weakly active on L-Val (PubMed:6067195).  Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation.  Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation.  These different effects are probably due to different experimental conditions (By similarity).
What are the official names of this protein?
L-amino-acid oxidase, LAAO, LAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HXKA_YEAST
Sequence: MVHLGPKKPQARKGSMADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKKGGNIPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSGNHTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDFMVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKRELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTGHIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSEKRIAEGKSLGIIGA
What is the function of this protein?
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:332086).  Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:332086).
What are the official names of this protein?
Hexokinase-1, Hexokinase PI, Hexokinase-A.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.