PharMolix/UniProtQA huggingface dataset:
Protein: NTPPB_RHILO
Sequence: MTEKIILASGSPFRKAMLINAGLDVEAVPADVDERALEAPLQDSGVSPEDVALVLAEAKATEVSERRPGALVLGCDQTLSLGDEVFHKPADMEGARRHLLALSGRTHQLNSAAVLVRDGKVLWRHVGIAGMTMRMLDPGFIGRHLALVGAKALASVGAYQIEGEGIQLFEKIEGDYFTIVGLPLLPLLAELRTLGAIDG
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IPA9_SHIBS
Sequence: MLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPLALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS
What is the function of this protein?
Effector E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell.  Interacts with IKBKG (NEMO) and TNIP1 (ABIN-1), a ubiquitin-binding adapter protein, which results in TNIP1-dependent 'Lys-27'-linked polyubiquitination of IKBKG.  Consequently, polyubiquitinated IKBKG undergoes proteasome-dependent degradation, which perturbs NF-kappa-B activation during bacterial infection.  Mediates polyubiquitination of host U2AF1, leading to its proteasomal degradation.  Catalyzes 'Lys-48'-linked polyubiquitination and subsequent degradation of a subset of host guanylate-binding proteins (GBP1, GBP2, GBP4 and GBP6), thereby suppressing host cell defense.  In contrast, host GBP3 and GBP7 are not ubiquitinated by IpaH9. 8.  Uses UBE2D2 (UBCH5B) as an E2 ubiquitin-conjugating enzyme.
What are the official names of this protein?
E3 ubiquitin-protein ligase ipaH9.8, Invasion plasmid antigen ipaH9.8.
What is the protein family that this protein belongs to?
Belongs to the LRR-containing bacterial E3 ligase family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus. Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm. Transported into the host nucleus (By similarity).
Protein: DLTA_STRPJ
Sequence: MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTGKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSLPIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLATLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMKNPEKTAEAFFEFEGLPAYHTGDVGTMTDEGLLLYGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDIMMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAGD_HUMAN
Sequence: MSQVLGKPQPQDEDDAEEEEEEDELVGLADYGDGPDSSDADPDSGTEEGVLDFSDPFSTEVKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKICREDVSNSSFVNFQIWDFPGQIDFFDPTFDYEMIFRGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSTPVDMQTYELCCDMIDVVIDISCIYGLKEDGAGTPYDKESTAIIKLNNTTVLYLKEVTKFLALVCFVREESFERKGLIDYNFHCFRKAIHEVFEVRMKVVKSRKVQNRLQKKKRATPNGTPRVLL
What is the function of this protein?
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:34607910).  Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form (PubMed:24095279).  In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279).  This is a crucial step in the activation of the TOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279).
What are the official names of this protein?
Ras-related GTP-binding protein D, Rag D, RagD.
What is the protein family that this protein belongs to?
Belongs to the GTR/RAG GTP-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942).
Protein: TDH_BURMA
Sequence: MKALAKLERGPGLTLTRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVLITGAGPIGVMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMSGVPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAVDDYEKGFAAMLSGESGKVILDWADA
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_PSEA6
Sequence: MIEADRLIQPTALREDEVIDRAIRPKMLADYTGQDHVCEQMDIFIQAARKRSDALDHLLIFGPPGLGKTTLANIVANEMGVSIKTTSGPVLEKAGDLAALLTNLEENDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLELPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYNIKDLTQIVKRSAHFLELNLDEEGAMEIAKRSRGTPRISNRLLRRVRDYAEIKANGEISSDVASAALDMLDVDKEGFDYMDRKLLTTIIDKFMGGPVGLDNLAAAIGEERDTIEDVIEPFLIQQGFLQRTPRGRIVSQRAYLHFGYDYEPN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: Y1769_HAEDU
Sequence: MKKQIFNEENVSIEKKIEPKQEFDATKVSVEDETEQLTAELIIEKGFTPSRFWIRGLLAVLVLFGLAVIARSVQCLIDSVQAHQWIDLAFAIVFFMVSLAGIGAIIREWYWLVYLRKHQDTQHISKQLLMDELLVTSGQDNVVICHQILADLKSLPHIAVAKQRWQSQLNEAYNAKEVLYLFSENVLKPLDTQVKQIIAKSATENAIIVAVSPLVIVDMLMIAWRNIALVNKISRLYGMRLGYLSRLKLFKMVLTNMVFAGATEMATDVGMDFFSQNLTAKVSLRAAQGIGVGLLTARLGIKAMEFCRPIAFQKEERPKISEIRQQLLIAVKNRFFAKNEA
What are the official names of this protein?
UPF0283 membrane protein HD_1769.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYT5_MOUSE
Sequence: MFPEPPTLGSPAPKTPPDSSRIRQGAVPAWVLATIVLGSGLLVFSSCFCLYRKRCRRRMGKKSQAQAQVHLQEVKELGRSYIDKVQPEIEELDRSPSMPGQQVSDKHQLGRLQYSLDYDFQTGQLLVGILQAQGLAALDLGGSSDPYVSVYLLPDKRRRHETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVNLGRPVQAWRELQVAPKEEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAVGGAGLRHWADMLANPRRPIAQWHSLRPPDRARPIPAP
What is the function of this protein?
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.  Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells.  Required for export from the endocytic recycling compartment to the cell surface.
What are the official names of this protein?
Synaptotagmin-5, Synaptotagmin IX, Synaptotagmin V, SytV.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Note=In mast cells, localizes to the endocytic recycling compartment.
Protein: HMG15_ARATH
Sequence: MASSSCLKQGSVPMNNVCVTPEATYEAVVADPRLFMTSLERLHSLLGTKFMVPIIGGRDLDLHKLFVEVTSRGGINKILNERRWKEVTATFVFPPTATNASYVLRKYYFSLLNNYEQIYFFRSNGQIPPDSMQSPSARPCFIQGAIRPSQELQALTFTPQPKINTAEFLGGSLAGSNVVGVIDGKFESGYLVTVTIGSEQLKGVLYQLLPQNTVSYQTPQQSHGVLPNTLNISANPQGVAGGVTKRRRRRKKSEIKRRDPDHPKPNRSGYNFFFAEQHARLKPLHPGKDRDISRMIGELWNKLNEDEKLIYQGKAMEDKERYRTEMEDYREKKKNGQLISNAVPLQQRLPEQNVDMAEADLPIDEVEEDDEEGDSSGSSGESEPHDDQSIETDPELEEPSLNPSGPNLNPNPTEIVVAPKEKNGDVVMETSPLKKADEPTVAVTAEQN
What is the function of this protein?
Binds preferentially DNA with A/T-rich content.
What are the official names of this protein?
High mobility group B protein 15, Nucleosome/chromatin assembly factor group D 15.
What is the protein family that this protein belongs to?
Belongs to the HMGB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SCPA_STRZJ
Sequence: MDIKLKDFEGPLDLLLHLVSKYQMDIYDVPITEVIEQYLAYVSTLQAMRLEVTGEYMVMASQLMLIKSRKLLPKVAEVTDLGDDLEQDLLSQIEEYRKFKLLGEHLEAKHQERAQYYSKAPTELIYEDAELVHDKTTIDLFLAFSNILAKKKEEFAQNHTTILRDEYKIEDMMIIVKESLIGRDQLRLQDLFKEAQNVQEVITLFLATLELIKTQELILVQEESFGDIYLMEKKEESQVPQS
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: LKB1A_MANHA
Sequence: MEANHQRNDLGLVALTMLAQYHNISLNPEEIKHKFDLDGKGLSLTAWLLAAKSLALKAKHIKKEISRLHLVNLPALVWQDNGKHFLLVKVDTDNNRYLTYNLEQDAPQILSQDEFEACYQGQLILVTSRASVVGQLAKFDFTWFIPAVIKYRKIFLETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNIITVALAIVIIFEIVLSGLRTYVFSHSTSRIDVELGAKLFRHLLSLPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLLFSFIFFAVMWYYSPKLTLVILGSLPCYILWSIFISPILRRRLDEKFARSADNQAFLVESVTSINMIKAMAVAPQMTDTWDKQLASYVSSSFRVTVLATIGQQGVQLIQKTVMVINLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTEQYQGKLSLPEIKGDISFKNIRFRYKPDAPTILNNVNLEIRQGEVIGIVGRSGSGKSTLTKLLQRFYIPENGQVLIDGHDLALADPNWLRRQIGVVLQDNVLLNRSIRENIALSDPGMPMERVIYAAKLAGAHDFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMQNMQKICQGRTVILIAHRLSTVKNADRIIVMEKGEIVEQGKHHELLQNSNGLYSYLHQLQLN
What is the function of this protein?
Part of the ABC transporter complex LktBD involved in leukotoxin export.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).
What are the official names of this protein?
Leukotoxin translocation ATP-binding protein LktB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASTD_CHRVO
Sequence: MSSLFIDGKWLAGDGEAMAKTNPADNAPLWQGRAASAAQVDAAVRAARAAFPAWARMGLEERAKVVRRFGERLTERKAELARVIAQETGKPLWEATTEVTTMVGKIDISLKALAERTGERAAAMGDAQAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNSVIFKPSELTPWTAEETVKLWAEAGLPAGVIGLVQGAKDTGVALAGHEGLDGLFFTGSSATGALLHKQFSGRPDKILALEMGGNNPLIVGEVADVDGAVHHVIQSAFVSAGQRCTCARRLLVPQGEWGDAFVARLVEVAGKLRVGKFDAEPAPFLGAVISNAAADALLKAQDDLVAAGGTPLLAMRRLEEGAAMLTPGIIDTTAAVRPDEEFFGPLLQVIRYADFDQAIAIANDTRFGLAGGVLSDSRELYDRYWLESRAGVVNWNKPLTGASSAAPFGGIGASGNHRPSAYYAADYCAYPVASLECDSLALPAQLSPGIVL
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: GYRB_STAAS
Sequence: MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX34A_PHONI
Sequence: MKVAILILSILVLAVASETIEEYRDDFAVEELERATCAGQDKPCKETCDCCGERGECVCALSYEGKYRCICRQGNFLIAWHKLASCKK
What is the function of this protein?
Inhibits voltage-gated sodium channels (Nav) (By similarity).  Causes scratching, lacrimation, hypersalivation, sweating and agitation followed by spastic paralysis of the anterior and posterior extremities and death at dose levels of 1. 62 mg/mouse.  Insecticidal to the larval and adult forms of the house fly.
What are the official names of this protein?
U2-ctenitoxin-Pn1a, U2-CNTX-Pn1a, Neurotoxin Tx2-1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 03 (Tx2) family. 04 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOB_TROWH
Sequence: MSLFGVGFLAFAKGKRVCAIGRSSLGKISDPLEVPNLLDLQLDSFDWLIGGPRWRAALDAYRKNPSGAPIAEKSGLDEVFDEISPIEDSAGNMQLNFSKPVLEAEELSVRECRVRGRTYSAPLYVEAEFMNHDTGEIKTQTVFMGDFPLMTDKGTFVINGTERVVVSQLVRSPGVYFERTPEKNSEKDLFSGRIIPARGAWLEFEVDRHDQLGVRVDRKRRQPVIFFLRAIGMTDDEIRDAFGEFESISVQHEKNIGLSRDDALREIYRRVRPGEQASAEAGRALLENFYFTSRRFDLARVGRYKVNRKLGVDVDPTRMVLTRSDIIATIRYLAALHLGFSEVAVLNSNKSVPISTDDIDHLGNRRIRPVGELVQNQLRAGLARMERVVRERMTTQDIEAIIPQTLINVMPIVAALKEFYGTSQLSQFMDQNNPLAGLTHKRRLSALGPGGLSRERAGVEVRDVNPSHYGRMCPIETPEGPNIGLIGSLACYSRVNSFGFIETPYRRVVNGKVTDDIEYMTATQEDEHAIAQASTPLRPDNSFVDERVLVRRKGGEVEVVPADQVDYMDVSGRQMVSVATSLIPFLEHNDANRALMGSNMQRQAVPLLVTESPLVGTGMERYVAIDAGDVLIAEDPGIVGDVSADVVTVKQDDGKHRDYHVGKFVRSNQGNCYNQRVVVRSGDRVEKGTVLADGPCTDKGELSLGRNLLVAFMPWEGYNFEDAIIISQNLVKDDTLSSIHIEEHEVSTRDTKLGSEEITRDLPNVSMDYIKDLDERGIIRIGAEVGPGDILVGKVTPKGETELSAEERLLRAIFNEKSMEVRDTSLKVPHGQQGTVIDVKLFDAVDGEDKLGAGINQRVVVYIAHKRKITEGDKLAGRHGNKGVISKILPVEDMPFMADGTPVDIILNPLGVPARMNFGQVLETHLGWISKQGWKIEGDPDWAKDIRVREAQPDSRVSSPVFDGISEGEITGLFSSVFPNRDGERAVGSDGKAILYDGRTGEPFPEPISVGYMYVLKLHHLVDDKIHARSTGPYSMIIQQPLGGKAQFGGQRFGEMEVWALEAYGAAHALQELLTIKSDDVVGRVKVYDAIVKGYPIPTPGVPESFKVIVKEMQSLCINIEVVSDGEDDVSADAETLQIEEGLDTSPKVEVGSLEEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: SSTT_STRPC
Sequence: MKKIYDLWVRVSLIKKIGIGVVIGVMLGILAPDLTGFSILGKLFVGGLKAIAPLLVFALVSQAISHQKKGKQTNMTLIIVLYLFGTFASALVAVLTAYLFPLTLVLNTPVNTELSPPQGVAEVFQSLLLKLVDNPINALATANYIGVLSWAIIFGLALKAASQETKHLIKTAAEVTSQIVVWIINLAPIGIMSLVFTTISENGVGILSDYAFLILVLVGTMVFVALVVNPLIAVLITRQNPYPLVLRCLRESGLTAFFTRSSAANIPVNMQLCQKIGLSKDTYSVSIPLGATINMGGAAITINVLTLAAVHTFGIPIDFLTALLLSVVAAVSACGASGVAGGSLLLIPVACSLFGISNDLAMQVVGVGFIVGVIQDSCETALNSSTDVLFTAIAENAFWKRKKA
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LYSZ_SULIY
Sequence: MIVVKIGGRVVKNSLDKVILDIANINDKVILVHGGGDIVTDYTKRLGIEPVFVTSPEGIRSRYTTKEELEVYIMAMSLINKTITSKLCSLGKNAIGITGVDGGLLLAERKKRIIVIDERGKKRIIEGGYTGKVKEVRSEVINHLMKLFDIIVVSPLALDVEESTPLNIDGDQAAFAISKAVKVNVLVILSDVEGVLVEGKVVDRLTPEEAKELSKKIGPGMNRKLLMAAESVENGVNKVIIGSGVKDRPVSSALELNGTVIVNG
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.  Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
What are the official names of this protein?
[LysW]-aminoadipate/[LysW]-glutamate kinase.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. LysZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GYRA_MYCS2
Sequence: MTDTTLPPEGEAHDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLGELAEAVYWCLENYEADEEATCEAVMERVKGPDFPTSGLIVGTQGIEDTYKTGRGSIKMRGVVEIEEDSRGRTSIVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVVELKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQLIRLYVDHQLDVIVRRTRYRLRKANERAHILRGLVKALDALDEVIALIRASQTVDIARAGLIELLDIDDIQAQAILDMQLRRLAALERQKIVDDLAKIEAEIADLEDILAKPERQRGIVRDELKEIVDKHGDARRTRIVPADGEVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDMVNHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIKSYEDAPYLVLATRNGLVKKSKLSDFDSNRSGGIVAINLREGDELVGAVLCSAEDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNEDDRLLSLNVVRPDTYLLVATSGGYAKRTSIDEYSVQGRGGKGILTIQYDRKRGSLVGALIVDDDTELYAITSTGGVIRTAARQVRKAGRQTKGVRLMNLAEGDTLIAIARNADEDEAAESISESDADTAESPEA
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner (PubMed:8878580) to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYBC_BRADU
Sequence: MSGPSDYQPSNPALQWIERRLPILGLMHSSFVAYPTPRNLNYWWTFGAILSFMLGMQILTGVILAMHYTPHADLAFKSVELIVRDVNYGWLLRNMHACGASMFFFAVYVHMLRGLYYGSYKEPREVLWILGVIIYLLMMATGFMGYVLPWGQMSFWGATVITNLFSAIPYFGESIVTLLWGGYSVGNPTLNRFFSLHYLLPFLIAGVVVLHVWALHVAGQNNPEGVEPKSEKDTVPFTPHATIKDMFGVACFLLLYAWFIFYMPNYLGDADNYIPANPGVTPPHIVPEWYYLPFYAILRSIPNKLAGVIGMFSAIIILCFLPWLDAAKTRSSKYRPLAKQFFWIFVAVCILLGYLGAQPPEGIYVIAGRVLTVCYFAYFLIVLPLLSRIETPRPVPNSISEAILAKGGKAVASVAIALVAAGALFLGSLQDARANEGSDKPPGNKWSFAGPFGKFDRGALQRGLKVYKEVCASCHGLSYIAFRNLAEAGGPSYSVAQVAAFASDYKIKDGPNDAGDMFERPGRPADYFPSPFPNEQAARAANGGAAPPDLSLITKARSYGRGFPWFIFDFFTQYQEQGPDYVSAVLQGFEEKVPEGVTIPEGSYYNKYFPGHAIKMPKPLSDGQVTYDDGSPATVAQYSKDVTTFLMWTAEPHMEARKRLGFQVFVFLIIFAGLMYFTKKKVWADSH
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.  c1 functions as an electron donor to cytochrome c.
What are the official names of this protein?
Cytochrome b/c1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS1_VARPS
Sequence: MITLALSKGRIFEETMPLLAAAGIEVTEDPEKSRKLILATTRPDVRVVLVRASDVPTYVQYGGADLGVTGLDVLLENGNQGMYQPLDLRIAACRLSVAVRADYDYASAVKQGSRLRVATKYVGLAREFFASKGVHVDLIKLYGSMELAPLTGLADAIVDLVSTGNTLKANHLVEVERIMDISARLVVNQAALKLKREPIRRIIDAFASAIPTA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.