PharMolix/UniProtQA huggingface dataset:
Protein: SGPP1_MOUSE
Sequence: MSLGQRLALLASRLQEPQRVASFQRLCGVEVPLSSPAADEDAETEVRGAPGEPRRRGRQPGAEDSPAKADCCGAPNGVRNGLAAEPGPTGPRRAGSQRRNSLTGEEGELVKVSNLPLYYLFCLGTELGNELFYILFFPFWIWNLDPFVGRRLVIIWVLVMYLGQCTKDIIRWPRPASPPVIKLEVFYNSEYSMPSTHAMSGTAIPIAMFLLTYGRWQYPLIYGLILIPCWSSLVCLSRIYMGMHSILDVIAGFLYTILILIIFYPLVDLIDNFNQTYKYAPLIIIGLHLILGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHAAYTLGLSLEPSLHMLPLAIPPLTVTLFGKAILRIVLGMLLVLFVRDIMKKITIPLACKLSSIPCHDIRQARQHMEVELPYRYITYGMVGFSITFLVPYVFSFIGIS
What is the function of this protein?
Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P (PubMed:10859351, PubMed:11756451).  Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid.  Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway.  Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:10859351, Ref. 2).  Involved in efficient ceramide synthesis from exogenous sphingoid bases.  Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase (PubMed:12235122, PubMed:17895250).  In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (PubMed:17895250).  Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (By similarity).  The modulation of intracellular ceramide levels in turn regulates apoptosis (PubMed:12235122).  Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries.  Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (By similarity).  Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (PubMed:23637227).
What are the official names of this protein?
Sphingosine-1-phosphate phosphatase 1, SPP, SPPase1, mSPP1, Sphingosine-1-phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the type 2 lipid phosphate phosphatase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mainly found in intracellular membrane fractions.
Protein: RNH2_PROM1
Sequence: MEDIKSLIAGVDEVGKGCLFGPVFAAAVILSKENEIELLNQGLKDSKKLSHRQRHNLVPLIKTNSIAWTIGQASAREIDVIGIRDATEKAMLRALEKFSSPPDLILVDGILPIRLWPGKQKTQVRGESHFASIAAASVLAKETRDELIKRLARKYNCYGLEKNKGYGTEIHRTNLIKEGATKLHRKSFISRLEIN
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PME63_ARATH
Sequence: MGYNYVSLIVTILLVVITSPVVFGNDAAPIPENKGRIEQWFNTNVKQNGRGHFKTITEAINSVRAGNTRRVIIKIGPGVYKEKVTIDRSKPFITLYGHPNAMPVLTFDGTAAQYGTVDSATLIVLSDYFMAVNIILKNSAPMPDGKRKGAQALSMRISGNKAAFYNCKFYGYQDTICDDTGNHFFKDCYIEGTFDFIFGSGRSLYLGTQLNVVGDGIRVITAHAGKSAAEKSGYSFVHCKVTGTGTGIYLGRSWMSHPKVVYAYTDMSSVVNPSGWQENREAGRDKTVFYGEYKCTGTGSHKEKRVKYTQDIDDIEAKYFISLGYIQGSSWLLPPPSF
What is the function of this protein?
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
What are the official names of this protein?
Putative pectinesterase 63, PE 63, Pectin methylesterase 63, AtPME63.
What is the protein family that this protein belongs to?
Belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: MNHG1_STAAN
Sequence: MIKIILISLALIFVIIGALISALAAIGLLRLEDVYSRAHAAGKASTLGAMSLLFGTFLYFIATQGFVNMQLIVAIIFVLITGPLSSHMIMKAAYNIKTPYTKKTKVDEISEDLKDTKL
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit G1, Mnh complex subunit G1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROQ_SHEHH
Sequence: MSSQPKILLVNGPNLNLLGRREPGHYGHHTLEQIVDDLKQSATQAGIQLDHIQSNAEHLLIEAIHNSDADMVIINPAAFTHTSVALRDALLGVAIPFIEVHLSNVHSREPFRHHSYFSDKAIGVICGLGAQGYQFALQAAIARIHAAEKQG
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: ARCC2_STAAR
Sequence: MKEKIVIALGGNAIQTKEATAEAQQTAIRRAMQNLKPLFDSPARIVISHGNGPQIGGLLIQQAKSNSDTTPAMPLDTCGAMSQGMIGYWLETEINRILTEMNSDRTVGTIVTRVEVDKDDPRFDNPTKPIGPFYTKEEVEELQKEQPGSVFKEDAGRGYRKVVASPLPQSILEHQLIRTLADGKNIVIACGGGGIPVIKKENTYEGVEAVIDKDFASEKLATLIEADTLMILTNVENVFINFNEPNQQQIDDIDVATLKKYAAQGKFAEGSMLPKIEAAIRFVESGENKKVIITNLEQAYEALIGNKGTHIHM
What are the official names of this protein?
Carbamate kinase 2.
What is the protein family that this protein belongs to?
Belongs to the carbamate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSN_VIBPA
Sequence: MNSAVEAQLAELGIEGYLKQHQYKSLLRFLTCGSVDDGKSTLIGRLLHDSKQIYEDQLAAVHSDSQRVGTTGEKPDLALLVDGLQAEREQGITIDVAYRYFSTQKRKFIIADTPGHEQYTRNMATGASTCDLAVILVDARKGILDQTRRHSFISNLLGLKHFVVAINKMDLVDYSQARFEEIRDEYLKFSENLTGDIDIQIIPISALEGDNVVDKGQNLNWFEGPSLLELLETVDVDYEKGAGEFRFPVQYVNRPNLDFRGFAGTVSSGSVKVGDAIKALPSGKTSTVARIVTFDGDIEEAQAGLAVTLTLNDEIDISRGDLIVLENAQVQTTNHLLADVVWMTEQPLQPGRDYDIKIAGKKTVGHVESIRHQYDINNLSTHGAAELPLNGIGLCEWSLNESVALDNYQDCADTGGFIIIDRLTNVTVGAGMVKESLTELERGLADVSAFELELNALVRKHFPHWEAKDLSQLLKK
What is the function of this protein?
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 1, ATP-sulfurylase large subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Protein: PSBL_METGY
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: T2D1_HERAU
Sequence: MFEQLNQPGLFGITNSNRDFTKKEAWGKNQFNNAFPIALACFMFSQNIKPIYIRLEKRNIEHNYFAVDQVFQINPLEAQAFFAFEHSYHPYTELIIGKTPAIDVVISNLQNSQIINAFEIKLTAIPDNTTANLPDNLQGCEIVIRPDTIVYLALSIAKVFQQNPLALLDILDPVCARIGDWEDATSIQPMIPLFCELLYTIFDRYQAVQIPILLQPIWKTQGKLSILHENCLDLFVWSNFALAKVFLDASIKPSEKSITRPERTTVWLIKMLYDFAQNGKIDYKRTLDRITFNLKNDKAFAASGMVTRKYMNSPELQNPRIKRHSIKHIIINGGQRYLSPERRLDSAIVSTPGLFEEIL
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GRCGYC-3' and cleaves after R-2.
What are the official names of this protein?
Type II restriction enzyme HgiDI, R.HgiDI, Endonuclease HgiDI, Type-2 restriction enzyme HgiDI.
Protein: CMT2_ORYSJ
Sequence: METPPPDPVSPPPPAADEGSPGGDDGAEDAGGFSAGLDSLWTALFGSPEELEPMWSPPRGFGVGAEFAAAEVEPEIMDVAGGPWDGAPWRSSGVVAGEGAATALVPPTAAAGFAEFEPAAPIDSYPAGAAAASLGDVPEVSALDSGVDCSPDPPPSSSPPVDFDARGFDPVADSAPAMESPLPPSVASSEANLDGRMLDCTLNSVPSPPLASPYEVGLGAEDPIKDSSPSVAWGTTMDAKDPEVDATCANGTALRRSRRIMKIKSAASSMPLNQNGDSSRASKRRVADSRKSRSSEGSKLPAFTGPISVNTVDLINGVKVQGLQEIVAVENVSSSYDNNQKAGGLYNQVVVALPAASNSLLKDKGASVLPRRKTRLASKVLVNSDRVSAISPVVNGGPPVQKSDVCIPTKKHKLAVEECLTSLDGVDGGGIVLCNSKLKSAKSRVVSKTPQGRGRRSPQPPKTQRARTLSVKYLEKLKRAENNNNNGSMSKSPRVPMIPENNGSMSKSPRVPIIPELSTKHELVLDKHMVDSVMLETDDGSCFFVGDAVPDDEARKQWPHRYEINDQIMKKDKRTSSQTFANAGKAVLDVKCHYLQAKVSRYTFCIGECAFVKGPEGKPNYIGRLLEFFETKTGECYFRVQWFFTAEDTVIGEQAQSHDPRRLFYSDLTDDNLLDCIVSKVTIVQVPPSVDGKSKSVPSSDYYYDMKYSIDYSTFSTIEMEDTDDLMQSCYTSRINDKMKKIDVNKKHKSPVLEKMELSLLDLYCGCGGMSTGLCLGARGGGVNLSARWAIDDDEIACESFRNNHPETRVRNETTDDFLELLKEWEKLCKTYVKHSRTKACVDSTTESNNETPDCSTVPPEEFEVWKLVDICFGDPNKVSKHGLYFKVRWKGYGPHHDTWEPVEGLRNCKEAIRDFVIEGHRQRILPRPGDVDVVCGGPPCQGISGYNRNREFEAPFKCEKNKQIIVFMDVVQFLKPKYVYMENVLDILKFADATLARYALSRLVAMHYQARLGIMAAGCYGLPQFRMRVFLLGCHSKEKLPPFPLPTHEAIVKNGCPLAFERNLVGWPNDTPMQLARPIVLEDILSDLPEVANGESRDEMLYVKGPQTEFQRYIRSFNVEVHGPRAHVTKDSKSSKLYDHRPLVLDNDNYQRILQIPKRKGANFRDLSGVIVGPDNVARLDPTKERVLLPSGRPLVLDCILAYENGKSLRPFGRVWWDEVVGTVLTVPNARMQALIHPAQDRLLTIRESARLQGFPDNYRFRGTVKDRYRQIGNAVAVPVGRALGYALAMAYLKKSGDDPLMLLPPNFAFSHDLRGFA
What is the function of this protein?
Involved in CpXpG DNA methylation.
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase CMT2, Chromomethylase 2, OsCMT2.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDRP1_STAES
Sequence: MDNIKIIVASDSIGETAELVARAGVSQFNPKQCKHEFLRYPYIESFENVDEVIQVAKDTNAIIVYTLIKPEIKKYMISKVNEHALKSVDIMGPLMELLSNSIEETPYYEPGMVHRLDDAYFKKIDAIEFAVKYDDGKDPKGLPKADIVLLGISRTSKTPLSQYLAHKSYKVMNIPIVPEVTPPDGLFNVDPSKCIALKISEEKLNRIRKERLKQLGLGDKARYATEARIQEELDYFEKLVDKIGCPVIDVSDKAIEETANDIIHFIEQNKSK
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein 1, PPDK regulatory protein 1.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: PYRH_HAEI8
Sequence: MSQPIYKRILLKLSGEALQGEDGLGIDPAILDRMAVEIKELVEMGVEVGVVLGGGNLFRGAKLAKAGMNRVVGDHMGMLATVMNGLAMRDSLFRADVNAKLMSAFQLNGICDTYNWSEAIKMLREKRVVIFSAGTGNPFFTTDSTACLRGIEIEADVVLKATKVDGVYDCDPAKNPDAKLYKNLTYAEVIDKELKVMDLSAFTLARDHGMPIRVFNMGKPGALRQVVTGTEEGTTIC
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP5B1_HUMAN
Sequence: MGPLSRDAWAQRLGAFRASPSAFMAGPEGEDLGRDLLSDLRSEKLSEQTKVSLLALSMEYPAQLWPDASAAEVAATSLLDTLVLLPPRPSALRRPLLLAATTALAAGGALGPTSGASCRLLPLLLGLAAGSDLGRGFVPASEQRPLQATACECLRELESCKPGLLGGSLGLLRGLLGQEGPVQPLSLLLALALRNTLVLQSRVGAGLGGLLTDKVSPTGGGPWDWTLVEEGDGRLQPQAPSWPAAEEGEGERSLTAREHSPEEARELRAAVIQLLDTSYLLTPVAQAQLLWLLGWALRGLQGQPPALFKPQLVRLLGTAQLTLLHAMLALKAAFGEALFTAQDEALLLRRLTLAAQHPALPPPTHLFYLHCVLSFPENWPLGPEGEEAAPLLLGPQLCRGLLPSLLHDPMALLARLHLLCLLCAEEEEEEKGQLPSPRHYLEELLAGLRQRAALDGGPRALATLCFQASYLVACCLAGQPTVLTPLIHGLAQLYQARPMLAPHFVDLLDQVDSELREPLKVVLRQVVVSRPGRDEALCWHLQMLAKVADGDAQSATLNFLQAAAAHCTNWDLQQGLLRVCRALLRAGVRGGLVDLLQVLARQLEDPDGRDHARLYYILLAHLAAPKLGVALGPSLAAPALASSLVAENQGFVAALMVQEAPALVRLSLGSHRVKGPLPVLKLQPEALEPIYSLELRFRVEGQLYAPLEAVHVPCLCPGRPARPLLLPLQPRCPAPARLDVHALYTTSTGLTCHAHLPPLFVNFADLFLPFPQPPEGAGLGFFEELWDSCLPEGAESRVWCPLGPQGLEGLVSRHLEPFVVVAQPPTSYCVAIHLPPDSKLLLRLEAALADGVPVALRTDDWAVLPLAGDYLRGLAAAV
What is the function of this protein?
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.
What are the official names of this protein?
AP-5 complex subunit beta-1, Adaptor-related protein complex 5 beta subunit, Beta5.
Protein: MIAB_ACTSZ
Sequence: MTQKLHIKTWGCQMNEYDSAKIADLLLSTHGLELTEEAEQADVLLLNTCSIREKAQEKVFSQLGRWKTWKNEKPGLIIGVGGCVASQEGEHIRERAPFVDIIFGPQTLHRLPEMINQIRGGKSSVVDVSFPEIEKFDCLPEPKAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPLDDVLFEVAQLADQGVREINLLGQNVNAYRGPTHDGGICTFAELLRLVASIDGIDRLRFTTSHPIEFTDDIIDVYADTPELVSFLHLPVQSGADRILTMMKRGHTALEYKSIIRKLRKVRPDIQISSDFIVGFPGETNEEFEQTMNLIADVNFDMSFSFVYSARPGTPAADMPDDVSEEEKKQRLYLLQQRINNQAAKFSRAMLGTEQRVLVEGPSKKDIMELTGRTENNRIVNFKGTPDMIGKFVDIQITDVFTNSLRGDVIRTEDEMGLRVEQSPQSVIRRTRKEDELGVGKYVA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCO1_DICDI
Sequence: MEIDIEKLPIIDISSFQNNENDKNQVAKEINKACKEYGFFYIKNHGVDQELIENLQNVIKKFFSLPLEIKMKWKMGLTNREWLGFFKVGQEITYGQVDWKEGCYYSSEMDGDINTIHNVPLYPTAEQEEQYEIQGFKSTIHTYIEKLTHLSQQIIEAISLSLNLPQDYFFKNYTYDPFILMGLLHYPSFHHQEQEEEQEDDESNNGGKKSPNPDESKKPEVEKFGTGQHTDWGLLTVLYQDDVGGLQVKSKNSEEYIDAPPIPGTFICNIGDMLDKMTGGYYLSNLHRVKYNKSGRDRFSIPFFLDPSLNSIPKLIPNYDQLSQFADKPERWDKQNIHEFDGTYGQYFIKKIGRVFPDYVYKKSGELV
What is the function of this protein?
Involved in ethylene biosynthesis.  Overexpression induces overproduction of ethylene.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate oxidase, ACC oxidase, Ddaco, Ethylene-forming enzyme, EFE.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: BAMC_PHOAA
Sequence: MAILLQKSKVMKIAGMSLAMLLAACSSDQSYKRQVNGDYAYLEAPPLKALNVPAGMILPLQNGEYDIPPTISKGLIGKELDIRPPSQALALLSGSRTENSIKSSKLLLENTPENSNLWSQINNVLLKKGDKISQRDDANQTLVTDWIEWQRTDEDVPYQTRHRISIAHQNYQIELSVANEGLRQGGQQVTDPVEIQRYNALMLNELIEGVNRQRERMSDNPAAHNLGPLDVQSGGDTSGLPQMIVRAPYNIVWDRLPAALEKVGMKVGNRSRSTGSITVAYKSLSTSEWKSMGVNEPSISEGDYKLQIGDLNNRSSLQFISDKGKPLTQVQNDELVAVLKAAFSQTAGL
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamC.
What is the protein family that this protein belongs to?
Belongs to the BamC family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: SSPA_STRGC
Sequence: MNKRKEVFGFRKSKVAKTLCGAVLGAALIAIADQQVLADEVTETNSTANVAVTTTGNPATNLPEAQGEATEAASQSQAQAGSKEGALPVEVSADDLNQAVTDAKAAGVNVVQDQTSDKGTATTAAENAQKQAEIKSDYAKQAEEIKKTTEAYKKEVEAHQAETDKINAENKAAEDKYQEDLKAHQAEVEKINTANATAKAEYEAKLAQYQKDLAAVQKANEDSQLDYQNKLSAYQAELARVQKANAEAKEAYEKAVKENTAKNAALQAENEAIKQRNETAKANYDAAMKQYEADLAAIKKAKEDNDADYQAKLAAYQAELARVQKANADAKAAYEKAVEENTAKNTAIQAENEAIKQRNAAAKATYEAALKQYEADLAAAKKANEDSDADYQAKLAAYQTELARVQKANADAKAAYEKAVEDNKAKNAALQAENEEIKQRNAAAKTDYEAKLAKYEADLAKYKKELAEYPAKLKAYEDEQAQIKAALVELEKNKNQDGYLSKPSAQSLVYDSEPNAQLSLTTNGKMLKASAVDEAFSHDTAQYSKKILQPDNLNVSYLQQADDVTSSMELYGNFGDKAGWTTTVGNNTEVKFASVLLERGQSVTATYTNLEKSYYNGKKISKVVFKYTLDSDSKFKNVDKAWLGVFTDPTLGVFASAYTGQEEKDTSIFIKNEFTFYDENDQPINFDNALLSVASLNRENNSIEMAKDYSGTFVKISGSSVGEKDGKIYATETLNFKQGQGGSRWTMYKNSQPGSGWDSSDAPNSWYGAGAISMSGPTNHVTVGAISATQVVPSDPVMAVATGKRPNIWYSLNGKIRAVNVPKITKEKPTPPVAPTEPQAPTYEVEKPLEPAPVAPTYENEPTPPVKTPDQPEPSKPEEPTYETEKPLEPAPVVPTYENEPTPPVKTPDQPEPSKPEEPTYETEKPLEPAPVAPTYENEPTPPVKTPDQPEPSKPEEPTYDPLPTPPVAPTPKQLPTPPVVPTVHFHYSSLLAQPQINKEIKNEDGVDIDRTLVAKQSIVKFELKTEALTAGRPKTTSFVLVDPLPTGYKFDLDATKAASTGFDTTYDEASHTVTFKATDETLATYNADLTKPVETLHPTVVGRVLNDGATYTNNFTLTVNDAYGIKSNVVRVTTPGKPNDPDNPNNNYIKPTKVNKNKEGLNIDGKEVLAGSTNYYELTWDLDQYKGDKSSKEAIQNGFYYVDDYPEEALDVRPDLVKVADEKGNQVSGVSVQQYDSLEAAPKKVQDLLKKANITVKGAFQLFSADNPEEFYKQYVSTGTSLVITDPMTVKSEFGKTGGKYENKAYQIDFGNGYATEVVVNNVPKITPKKDVTVSLDPTSENLDGQTVQLYQTFNYRLIGGLIPQNHSEELEDYSFVDDYDQAGDQYTGNYKTFSSLNLTMKDGSVIKAGTDLTSQTTAETDAANGIVTVRFKEDFLQKISLDSPFQAETYLQMRRIAIGTFENTYVNTVNKVAYASNTVRTTTPIPRTPDKPTPIPTPKPKDPDKPETPKEPKVPSPKVEDPSAPIPVSVGKELTTLPKTGTNDSSYMPYLGLAALVGVLGLGQLKRKEDESN
What is the function of this protein?
Adhesin that mediates binding of bacteria to a variety of host cells.  Plays a role in the bacterial invasion of dentinal tubules (PubMed:9393810).  A host immunostimulatory component, it modulates the innate immunity response.  Plays a protective role against some antibiotics and cationic antimicrobial peptides (histatin-5, HTN3, but not beta-defensin 4A, DEFB4A).  Purified soluble protein stimulates human epithelial cells to produce IL-6 and monocyte chemotactic protein (MCP-1, CCL2) probably via interaction with integrin beta-1 (ITGB1) (PubMed:22609749).
What are the official names of this protein?
Streptococcal surface protein A, Adhesin SspS.
What is the protein family that this protein belongs to?
Belongs to the antigen I/II family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Cell surface; Peptidoglycan-anchor.
Protein: TYSY_THISH
Sequence: MQPYLDLMRQLLEHGTVKSDRTGTGTRSLFGHQMRFDLSKGFPLVTTKKLHLKSIIHELLWFLKGETNIAYLKDNGVRIWDEWATEDGELGPVYGRQWRAWPTPDGRHIDQISQVVEQIRTRPDSRRLIVSAWNVAELPDEGISPKDNARAGRMALAPCHTFFQFYVADGRLSCQLYQRSADVFLGVPFNIASYALLTLMVAQVTDLEPGDFVHTFGDVHLYSNHVEQAKEQLSREPYPLPKMHLNPEVKSLFDFRYEDFTLEGYQAHPHIKAPVAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APRN_ENTHI
Sequence: VQVSIGKCNHNPSDQWLDNISRWSNDRMPIDSIGIDLGLQTTQPYSINDTFKIGSPIGGMIYLRFDTTFTNSFYVTFYNVGRASIINYNITMNEEWNSVLKNAPGNVAEIRTPGNRLVFTSRHIRNLEDAQYISDYWLKAISISNYAVTLENIPITLNFDQRVDAGAAVAFVDRWFTQHPSDWASGCVNKEGLINSGNWGPLHEMNHHMQGPYLRGGNWGIKEPGEETNNVMTSINYILYTNIAGHRNQGLSGWNYVSDGYSTIYKILNGENDQPHLRSYVNIAHAFGTDTLIALVKSYYGLWYENNYEGEYSIKRDSTSAFCLLAAIATKRDTRYLCSLFKYDIQQNVSEAIKNMNYPTYYPFFNVYAMSYNGNYYGRTYKIPYGTTRLNFTATTAIDPSATSVSYTIKSGLTKGKLEQVEENVYDYTPNFGADENDTFVLNIDCIVNGEKVHIEQDGTFELDPHQVEYEVYKDVKTKDMEQALNTIQNKTSNYTGTSTFFDIGNYDDGTMQSMLVEKGKLIVPTSGYYTLFMKADDLGRLLLNVNGEYEQLLNVKTYLGGYSKTINGTYATVKLEKDTEYPFILYNLNTGGQGFIRIGYCYQGTDQSSVNVSKCSVLDIGSSMILNEKVKAGAKEPEF
What are the official names of this protein?
Antigenic protein NP1, Non-pathogenic protein 1.
Protein: SYV_THEVO
Sequence: MDLDIDQMEKKWLKYWEDNDIYTFIPSEREKVFTIDTPPPTVSGKMHMGHSFSYSHIDFIARYKRMRGYHVFFPWGFDDNGLATERYVEKETGIKPTDGNVEHFINLCREFSQASEKALIEGWKRMGMSCYFKDYYVTSSPESVKISQSMFLDLVKKNRVYRDLAPTIRCPTCKTSISQIEMKDEMLKSKLVYINFDVEGSKLTIATSRPELLGSCVALFVNNEDERYKNIIGREATVPLFGHKVPIMGDESIDKDFGTGAEMVCTFGDQNDLDLWKKYSLPLRISIDKDGKMNENAGPLNGLSINDGRKKIIELLKSEGFVVKEEDIKHSVNTHERCGTPVEIFIEKQWFIRYLDLKKDFIDSGRAVKWIPDYMRTRYENWVNGLKWDWCISRQRYYGVPFPVWYCSDCGNTVFADDKDLPVDPRLQPPSKRCDKCGSSNLVPERDVMDTWATSSLTPRIALSHFGLFDKYYPEDLRGQGHDIISFWAFTTIARSKIHDNTIPWLTLMISGNVFDMYGEKMSKSKGNIVDIYAITDKYGADALRFWASTVSQGEDIRVKEQDFVRGRRTVIKMYNANRLIDILRNGRPLKNVDEPKHPVNLWILTEESKVVKLVTDSMDNYEVSKARSALDVFFWNTFCDNYLEMIKAIVQAANEKNDLGTVDETIYTASKVMRDVVKMYAPIMPFITEEIYQSIEIEGKKKSVHIDCWPMENREYVEASEVRYVTSIIDKIRAAKSNAKVSVGTPVRKALIKCNASIAEKYRDMLSRMMRIGSIDIEDSDKLEVSVEP
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYH7_MESAU
Sequence: MADREMAAFGAAAFLRKSEKERLEAQTRPFDLKKDVFVPDDKEEFVKAKIVSREGGKVTAETENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKDGYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPAHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFIPQGETTVASIDDSEELMATDSAFDVLGFTSEEKNSIYKLTGAIMHFGNMKFKQKQREEQADRDGTEEEDKSAYLMGLNSADLLKGMCHPRVKVGNEYVTKGQNVQQVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMRIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPVDKGKGKAKKGSSFQTVSVLHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGLLSRMEFKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKDKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDEKLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNTLAHALQSARHDCDLLREQYEEETEAKAELQCVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSTGKSIHELEKIRKQLEAEKMELQSALEEAEASLEHEEGNILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKGLNEE
What is the function of this protein?
Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction.  Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
What are the official names of this protein?
Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, Myosin heavy chain, cardiac muscle beta isoform, MyHC-beta.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere. Note=Thick filaments of the myofibrils.