PharMolix/UniProtQA huggingface dataset:
Protein: RL4_STAHJ
Sequence: MANYDVLKVDGSKSGSVELSDSVFAIEPNNSVLFEAINLQRASLRQGTHAVKNRSAVRGGGRKPWRQKGTGRARQGTIRAPQWRGGGIVFGPTPRSYAYKMPKKMRRLALRSALSFKVKENNFTIVDNFGFEAPKTKEFKNVLTTLEQPKKVLVVTDSEDVNVELSARNIPGVQVSTAQGLNVLDITSADSVIITESAAKKVEEVLG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ZN883_HUMAN
Sequence: MESEKIYMTANPYLCTECGKGYTCLASLTQHQKTHIGEKPYECKICGKSFTRNSNLVQHQRIHTGEKPYECNECGKAFSQSTNLIQHQRVHTGEKPYECNECEKTFSHRSSLRNHERIHTGEKPYPCNECGKAFSHISALTQHHRIHTGKKPYECTECGKTFSRSTHLIEHQGIHSEEKSYQCKQCRKVFCHSTSLIRHQRTHTGEKPYECNECGKAFSHTPAFIQHQRIHTGEKPYECNACGKAFNRSAHLTEHQRTHTGEKPYVCKECGKTFSRSTHLTEHLKIHSCVKPYQCNECQKLFCYRTSLIRHQRTHTGEKPYQCNECGKSFSLSSALTKHKRIHTRERPYQCTKCGDVFCHSTSLIRHQKTHFRKETLAE
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 883.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNAJ_BRUA4
Sequence: MKIDYYEALGVERTADDKVLKTAFRKLAMEYHPDRNPNNPEAERKFKEIGEAYETLKDPQKRAAYDRFGHAAFENGGMGGGFGNGFGGSGGFADIFEDIFGEMMGGGRRRSNGGRERGADLRYNMEVTLEEAYAGKTAQIRVPTSITCDECSGSGAKAGSQPTTCTMCSGSGRVRAAQGFFSVERTCPTCNGRGQIIKDPCGKCHGQGRVTQERSLSVNIPAGIEDGTRIRLSGEGEAGMRGGPSGDLYIFLSVKPHEFFQRDGSDLYCKVPISMTTAALGGQFEVSTLDGTQTRVKVPDGTQNGKQFRLKGKGMPVLRQAAVGDLYIQIDIETPQNLSKRQRELLEEFEKLSSQENSPKSAGFFSRMKEFFEGIGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CJE2_CONFR
Sequence: MPSVRSVTCCCLLWMMLSVQLVTPGSPGTAQLSGQRTARSSGSTVCKMMCRLGYGHLYPSCGCRGKRDVVSSSMAV
What is the function of this protein?
Highly inhibits both nicotinic acetylcholine receptors (neuronal (alpha-3/beta-4) and muscular (alpha-1/beta-1/epsilon/delta) subtypes) and the voltage-gated potassium channel Kv1. 6/KCNA6 subtype.
What are the official names of this protein?
Alpha/kappa-conotoxin-like fe14.2.
What is the protein family that this protein belongs to?
Belongs to the conotoxin J superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CLPT1_MOUSE
Sequence: MAAAQEADGAGSAVVAAGGGSSGQVTSNGSIGRDTPAETQPQNPPPQPAPNAWQVIKGVLFRIFIIWAISSWFRRGPSPQDQSGPGGAPRVASRNLFPKDTLMNLHVYISEHEHFTDFNATSALFWEQHDLVYGDWTSGENSDGCYEHFAELDIPQSVQQNGSIYIHVYFTKSGFHPDPRQKALYRRLATVHMSRMINKYKRRRFQKTKNLLTGETEADPEMIKRAEDYGPVEVISHWHPNITINIVDDHTPWVKGSVPPPLDQYVKFDAVSGDYYPIIYFNDYWNLQKDYYPINESLASLPLRVSFCPLSLWRWQLYAAQSTKSPWNFLGDELYEQSDEEQDSVKVALLETSPYLLALTIIVSIVHSVFEFLAFKNDIQFWNSRQSLEGLSVRSVFFGVFQSFVVLLYILDNETNFVVQVSVFIGVLIDLWKITKVMDVRLDREHRVAGIFPCPTFKDKSTYIESSTKVYDDMAFRYLSWILFPLLGCYAVYSLLYLEHKGWYSWVLSMLYGFLLTFGFITMTPQLFINYKLKSVAHLPWRMLTYKALNTFIDDLFAFVIKMPVMYRIGCLRDDVVFFIYLYQRWIYRVDPTRVNEFGMSGEDVSAAASRAQASTAAGALTPAPSTAVSGEDASTVPKATSGACTASQPQEAPPKPAEDKKKD
What is the function of this protein?
Involved in GABAergic but not glutamatergic transmission (PubMed:29395912).  Binds and traps GABAA receptors in the endoplasmic reticulum (ER) (PubMed:29395912).  Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors (PubMed:29395912).  Altered GABAergic signaling is one among many causes of cleft palate (PubMed:29395912).  Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity).  Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (By similarity).  May play a role in T-cell development (PubMed:9218588).
What are the official names of this protein?
Putative lipid scramblase CLPTM1, Cleft lip and palate transmembrane protein 1 homolog, Thymic epithelial cell surface antigen.
What is the protein family that this protein belongs to?
Belongs to the CLPTM1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BETB_KLEP3
Sequence: MSRMAEQQLYINGGYTSATSGRTFETINPATGEVLATVQAAGREDVDRAVESAQRGQKIWAAMTAMERSRILRRAVDLLRQRNDELARLETLDTGKPLSETAAVDIVTGADVLEYYAGLIPALEGSQIPLRDSSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYSEAGLPDGVFNVLPGIGAETGQYLTEHPGIAKISFTGGVASGKKVMANSAASSLKEVTMELGGKSPLIIADDADLDLAADIAMMANFYSSGQVCTNGTRVFVPAKQKAEFEHKILERVGRIRPGDLFADDTNFGPLVSFPHRDNVLRYIESGKREGARLLCGGEALKGDGFDNGAWVAPTVFTDCSDEMTIVREEIFGPVMSILSYTDEAEVIRRANATEYGLAAGVVTPNLNRAHRLIHQLEAGICWINSWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVEMGKFQSIF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: RL4_CLOTE
Sequence: MPTVGLFNKEGQKVGDFQLSDKVFGVEVNKEVLHQVIVAQLANKRQGTQSSKTRAEVSGGGRKPWRQKGTGRARQGSIRAPQWIKGGVVFAPKPRDYSMAIPKSMKRVAMKSALSSKVQENEIVILESLEADAPKTKEIVKMLAAFNAKKTLIVTEESNKNIYKSARNIEGVTVLPVNNINVYDILRYDKFIITKDAVSKIEEVYA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: BRE1_NEUCR
Sequence: MPVATSPSAVPRPTTVKMEDRKRPAANADDVAPPSKRQAVNGTSKSKDDSNDSREEAWIEEYQKGAIYRQMLEYKRSKVDLEHRLQEAEKSAAFHDDHLRVIKYWLSQLTQELELIVEGSLKSIALKPVDSNWVSSLAFKDSKEFRQHLDDIKKPVILKVESLLNKLASSRGEVKPDVAQLEAQVKSLLANQKELAVKIDRLQAENATLSEQYDTATLKVIKAERKLDRVRSAQVQKLEQQALANSTTRQTTNDENGTSSIAENGDGAEYKTKYKEAIAVANKQKEQIESLLAEIKTLQEENASFKIKKEGISEEDYARTDVFKQFKAQNEDLIKRINNLEAVNKQFREDAEKLRAERTSYRATLEQEAQALTSDLEDQIQQKDQDLTRIRSARDELLAELAMRKASQEQEKTASAHLNELVEAMTDRVTQLESELERLRPTEDVAKAAPTDDLSTLSAEELREKFAKLERDYEAINKELPALEKSYRKAMGIAHKKVMDFTALEERVAILTAEKSKADQKYFAARKDMDIRIAEIRTLRGQNSKSSEIISQLKDVETQHRALITTLEKQIADLKQSNITIVTESKKLESLSSEATRRADSVKSQIENLQNLVKSKDTAGRELKEKAIDKEQEAEKLKVRLDKVSSERDKWKTKCQSNSTEEEEMLRNLVLCSVCRSNFKNTILKGCGHVFCNECVDNRLANRMRKCPSCNKAFDRSDAMPAHL
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1.  H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
What are the official names of this protein?
E3 ubiquitin-protein ligase bre1, RING-type E3 ubiquitin transferase bre1.
What is the protein family that this protein belongs to?
Belongs to the BRE1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOB_RICRS
Sequence: MVSLRDNIEAQPLSHNRRIRKNFGHINLVADIPNLIEIQKNSYEKNFLQLNIKDSERKNKGLQSILNSIFPISDSSNVANLEFVKYEFDTPKYDVEECSQRSLSYAAPLKVTLRLSIWDIDEDTGTREIKGIKEQEVYMGDIPLMTKNGTFIINGTERVVVSQMHRSPGVFFYHDEGKVHSSGKLLYSARVIPYRGSWLDLEFDAKDVIYFRIDRKRKLYATTLLRAIGMSTEEIIKFYYNSVTYKLVKNKGWAVKFIPQHITAHRLTSDLVDADTGNILLKAGQKITPRLAKKYFGEGLNNILVAHETLIGKYLSEDLRDPASDEVLAKIGEMITADMLNVINDLKIKNVNVLVINPQSGPYIRNTLFADKNQDREAALCDIFRVLRPGEPANIEAAESLFYNLFFDTERYDLSEVGRIKMNSRLELNISEEVTVLTIDDIKNIVRVLVELKDGKGIIDDIDHLGNRRVRSVGELIENQFRIGLVRMEKSVIERMSAGDVDTVMPHDLVNSKILVSVVKEFFSTSQLSQFMDQTNPLSEITHKRRLSALGPGGLSRDRAGFEVRDVHPTHYGRICPIETPEGQNIGLINSMATYARINKHGFIESPYRRVKDGCVTDEVVYLSAIEEGKYKIGQANSKINKDGKLQGEFINCRVEGGNFVMVEPYEVDFIDVTPMQVVSVAASLIPFLENDDANRALMGSNMQRQAVPLIKTDAPFVGTGVEGVVAKDSGASVLALHDGIVEQVDSNRIVIRTLEQKVDGSPSVDIYNLLKFQKSNHNTCINQKPLVKVGHYVKKNDIIADGPSTDNGEIALGRNVLVAFLPWNGYNFEDSILISERIVKEDVFTSIHIEEFEVIARDTRLGPEEITRDIPNVSEEALRHLDEVGIIYIGAEVKAGDILVGKVTPKSESPITPEEKLLRAIFGEKAFDVKDSSLHVPSGVSGTVVEVRVFSRRGVEKDQRAIAIEKQQIEKFAKDRDDELEIIEHFVFSWLEKLLVGQVIINGPKQVKVGQTITTEMLKGLSKGQFWQITVEDANVMNEIEQIKTHYDEKKEALDKRFATKVEKLQSGDDLPQGALKVVKVFIATKHKLQPGDKMAGRHGNKGVISRIVPEEDMPFLEDGTVVDIVLNPLGLPSRMNIGQILETHLGWASINLAKKISTLVKEYKNKHIGIEQIKKFLIELYGENINSILERPEEEIIAFCKKVSKGVHFATPVFDGAKVQDVKDMLKLAGQDPSGQVKLIDGRTGEYFDRLVTVGQKYLLKLHHLVDNKIHSRSIGPYSLVTQQPLGGKSHFGGQRFGEMECWALQAYGAAYTLQEMLTVKSDDVNGRIKTYDSIVRGENNFESGIPESFNVMIKEFRSLCLNVKLEVTSS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: NRDR_LACLM
Sequence: MRCPKCSSEESKVVDSRQAEDAIRRRRVCESCGFRFTTFERIEEMPLLVIKKDDKREPFNREKIVRGLVRSAYKRPVSSEDIETTVANVERKIRQLDSNEVESDVIGEFVMQELAELDDITYIRFASVYRSFKDVSELEELLKNITKK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: SYS_BACLD
Sequence: MLDVKLLRANFEEIKQKLAHRGEDLSDFDQFEELDTKRRELIVKVEELKGKRNEVSQQVAALKREKKDADHLIKEMREVGEDIKKLDEELRTVESSLDKIMLSIPNIPHESVPVGETEDDNVEVRKWGELPEFSFEPKPHWDIADQLDILDFERAGKVTGSRFVFYKGLGARLERALYNFMLDLHVDEYGYTEVIPPYMVNRASMTGTGQLPKFEEDAFKIREEDYFLIPTAEVPITNLHRDEILSADELPINYAAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNQAEKVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWIPSQNTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRTVAALLENYQQEDGSVIIPKALRPYMGNRDVIQP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFLAR_MOUSE
Sequence: MAQSPVSAEVIHQVEECLDEDEKEMMLFLCRDVTENLAAPNVRDLLDSLSERGQLSFATLAELLYRVRRFDLLKRILKTDKATVEDHLRRNPHLVSDYRVLLMEIGESLDQNDVSSLVFLTRDYTGRGKIAKDKSFLDLVIELEKLNLIASDQLNLLEKCLKNIHRIDLNTKIQKYTQSSQGARSNMNTLQASLPKLSIKYNSRLQNGRSKEPRFVEYRDSQRTLVKTSIQESGAFLPPHIREETYRMQSKPLGICLIIDCIGNDTKYLQETFTSLGYHIQLFLFPKSHDITQIVRRYASMAQHQDYDSFACVLVSLGGSQSMMGRDQVHSGFSLDHVKNMFTGDTCPSLRGKPKLFFIQNYESLGSQLEDSSLEVDGPSIKNVDSKPLQPRHCTTHPEADIFWSLCTADVSHLEKPSSSSSVYLQKLSQQLKQGRRRPLVDLHVELMDKVYAWNSGVSSKEKYSLSLQHTLRKKLILAPT
What is the function of this protein?
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells.  Acts as an inhibitor of TNFRSF6 mediated apoptosis.  A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex.  Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis.  Lacks enzymatic (caspase) activity (By similarity).
What are the official names of this protein?
CASP8 and FADD-like apoptosis regulator, Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
Protein: PUR9_SALG2
Sequence: MQQRRPVRRALLSVSDKAGIIEFAQALSARGVELLSTGGTARLLAEKGLAVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDAIMEQHHIAPIDMVVVNLYPFAETVARVGCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYDAIIKEMDANEGSLTLDTRFDLSIKAFEHTAAYDSMIANYFGSMVPAYHGESKEAAGRFPRTLNLNFIKKQDMRYGENSHQQAAFYIEENVKEASVATAQQVQGKALSYNNIADTDAALECVKAFNEPACVIVKHANPCGVAVSTSILDAYDRAYKTDPTSAFGGIIAFNRELDAETAQAIISRQFVEVIIAPSATEEALKITAAKQNVRVLTCGQWAQRVPGLDFKRVNGGLLVQDRDLGMVSEAELRVVSKRQPTEQELRDALFCWKVAKFVKSNAIVYAKENMTIGIGAGQMSRVYSAKIAGIKAADEGLEVKGSAMASDAFFPFRDGIDAAAAVGVSCVIQPGGSIRDDEVIAAADEHGIAMIFTDMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: HAP1_YEASK
Sequence: MSNTPYNSSVPSIASMTQSSVSRSPNMHTATTPGANTSSNSPPLHMSSDSSKIKRKRNRIPLSCTICRKRKVKCDKLRPHCQQCTKTGVAHLCHYMEQTWAEEAEKELLKDNELKKLRERVKSLEKTLSKVHSSPSSNSLKSYNTPESSNLFMGNDEHTTLVNANTGSASSASHMHQQQQQQQQQEQQQDFSRSANANANSSSLSISNKYDNDELDLTKDFDLLHIKSNGTIHLGATHWLSIMKGDPYLKLLWGHIFAMREKLNEWYYQKNSYSKLKSSKCPINHAQAPPSAATRKCPVDHSAFSSGMVAPKEETPLPRKCPVDHTMFSSGMIPPREDTSSQKRCPVDHTMYSAGMMPPKDETPSPFSTKAMIDHNKHTMNPPQSKCPVDHRNYMKEYPSDMANSSSNPASRCPIDHSSMKNTAALPASTHNTIPHHQPQSGSHARSHPAQSRKHDSYMTESEVLATLCEMLPPKRVIALFIEKFFKHLYPAIPILDEQNFKNHMNQMLSLSSMNPTVNNFGMSMPSSSTLENQPITQINLPKLSDSCNLGILIIILRLTWLSIPSNSCEVDLGEESGSFLVPNESSNMSASALTSMAKEESLLLKHETPVEALELCQKYLIKFDELSNISNNNVNLTTVQFAIFYNFYMKSASNDLTTLTNTNNTGMANPGHDSESHQILLSNITQMAFSCGLHRDPDNFPQLNATIPATSQDVSNNGSKKANPSTNPTLNNNMSAATTNSSSRSGSADSRSGSNPVNKKENQVSIERFKHTWRKIWYYIVSMDVNQSLSLGSPRLLRNLRDFSDTKLPSASRIDYVRDIKELIIVKNFTLFFQIDLCIIAVLNHILNVSLARSVRKFELDSLINLLKNLTYGTENVNDVVGSLINKGLLPTSEGGSVDSNNDEIYGLPKLPDILNHGQHNQNLYADGRNTSSSDIDKKLDLPHESTTRALFFSKHMTIRMLLYLLNYILFTHYEPMGSEDPGTNILAKEYAQEALNFAMDGYRNCMIFFNNIRNTNSLFDYMNVILSYPCLDIGHRSLQFIVCLILRAKCGPLTGMRESSIITNGTSSGFNSSVEDEDVKVKQESSDELKKDDFMKDVNLDSGDSLAEILMSRMLLFQKLTKQLSKKYNYAIRMNKSTGFFVSLLDTPSKKSDSKSGGSSFMLGNWKHPKVSNMSGFLAGDKDQLQKCPVYQDALGFVSPTGANEGSAPMQGMSLQGSTARMGGTQLPPIRSYKPITYTSSNLRRMNETGEAEAKRRRFNDGYIDNNSNNDIPRGISPKPSNGLSSVQPLLSSFSMNQLNGGTIPTVPSLTNITSQMGALPSLDRITTNQINLPDPSRDEAFDNSIKQMTPMTSAFMNANTTIPSSTLNGNMNMNGAGTANTDTSANGSALSTLTSPQGSDLASNSATQYKPDLEDFLMQNSNFNGLMINPSSLVEVVGGYNDPNNLGRNDAVDFLPVDNVEIDGLVDFYRADFPIWE
What is the function of this protein?
Regulation of oxygen dependent gene expression.  It modulates the expression of Iso-1 (CYP1) and Iso-2 (CYP3) cytochrome c.  In response to heme, promotes transcription of genes encoding functions required for respiration, controlling oxidative damage and repression of anaerobic genes.  Binds to the sequence 5'-CGGNNNTNNCGG-3'.  Is non-functional in terms of iso-1 cytochrome c expression in strain S288c and its derivatives (By similarity).
What are the official names of this protein?
Heme-responsive zinc finger transcription factor HAP1, CYP1 activatory protein, Heme activator protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: H2A6_WHEAT
Sequence: MAGRKGGERKKAVTRSVKAGLQFPVGRIGRYLKKGRYAQAVGSGAPVYLAAVLEYLAAEVLELAGNAAKDNKKTRIIPRHLLLAVRNDQELGRLLAGVTIAHGGVIPNINSVLLPKKAAGAAEKESTKSPKKKAATKSPKKKTAATKE
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Protein H2A.6, wcH2A-3.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: NU3M_ORYPA
Sequence: MNMLLIMLTNIVLSSLLISVAFWLPQPNSYVLKASPYECGFDPMSSACLPFSMKFFLVGITFLLFDLEIALLLPIPWAMQYTDTHLTMAASFILVSILTLGLAYEWLNKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TSAD_LATSS
Sequence: MTEKKELILAFESSCDETSVAVIENGQRILSNVIATQIKSHQRFGGVVPEVASRHHVEQITLCTQEALEQAGVTYDDLTAVAVTYGPGLVGALLIGVTAAKAIAYAHHLPLVPVNHMAGHIYAARFVKPLEYPLLALLVSGGHTELVYMPAAGQFEIIGDTRDDAAGEAYDKIGRVLGVPYPAGKEIDRLAHLGQDTFNFPRAMLKEDNLDFSFSGLKSAFINTVHHADQIGETLDQADLAASFQASVVEVLVTKTLRAAQSLKVKQLVVAGGVAANQGLREGLAAGIESAGLDLDLIMPPLRLCGDNGAMIGAAAHIALAQNTLADLDLNAIPSLDFPYQNEL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGLS_RUMAL
Sequence: MIKLDWNEYLEKAAEVNAEGAVLLVNNGVLPLDKNAVTQVFGRIQLDYYKSGTGSGGMVNVAKVTGITDGLIEAGAKLNEDVLKAYKDYVAEHPYDYGEGWGGEPWCQEEMPLDDSLVKRAAESSDTAICIIGRTAGEEQDNSCKAGSYLLTDGEKAILRKVRDNFSKMVILLNVGNIIDMGFIDEFSPDAVMYVWQGGMTGGTGTARVLLGEVSPCGKLPDTIAYDITDYPSDKNFHNRDVDIYAEDIFVGYRYFDTFAKDRVRFPFGYGLSYTQFEISAEGRKTDDGVVITAKVKNIGSAAGKEVVQVYLEAPNCKLGKAARVLCGFEKTKVLAPNEEQTLTIEVTERDIASYDDSGITGNAFAWVEEAGEYTFYAGSDVRSAKECFAFTLDSTKVIEQLEQALAPVTPFKRMVRTAEGLSYEDTPLSKVDEAARRLGYLPAETAYTGDKGIALSDVAHGKNTLDEFIAQLDDNDLNCLVRGEGMCSPKVTPGTAAAFGGVAKHLEELGIPAGCCSDGPSGMRLDVGTKAFSLPNGTLIAATFNKSLITELFTYLGLEMRANKVDCLLGPGMNIHRHPLNGRNFEYFSEDPFLTGTMAAAELEGLHSVGVEGTIKHFCANNQETNRHFIDSVASERALREIYLKGFEIAVRKSKARSVMTTYGKVNGLWTAGSFDLNTMILRKQWGFDGFTMTDWWANINDRGCAPDKNNFAAMVRAQNDVYMVCADGESGSDNVIAALADGRLTRAELQRSARNILSFMMSTHAMARKLGEDEAVEVINKPAETVDDGEGDRVFLLDGDLTIDMSGVKTERNLDYSFTVDVAQFGQYRMEMTASSTQSELAQMPVTVFSMGTAWGTFTWNGTGGKPVTFAVEEMPMFSRYTIFRLHFGLGGLDMDKIVFKKIRPAEAQVCRLRISERWLQTQTYFWLKANFQSKKLLRGRRAYR
What are the official names of this protein?
Beta-glucosidase, Beta-D-glucoside glucohydrolase, Cellobiase, Gentiobiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
Protein: RL14_STRA3
Sequence: MIQQETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVKQATPGGAVKKGDVVKAVIVRTKTGARRPDGSYIKFDDNAAVIIRDDKTPRGTRIFGPVARELREGGYMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: IF6_METPE
Sequence: MIRTLAYEGDPHIGIFTRVLEDIAVVPPEASADYCAALKEALGVTLVKTHVQGSSIIGSLVSGNSRGAIVSGLAYPDEIRAIEEYREVMLLEGSMNAAGNVILANDQMAAVHPDMDNATIEQIHSVLGVPVIRLTLSGIKTVGMAGYATNRGILVHARSAGRELATLESTTDLPVGTGTINMGSGLVGTGLLANSTGYLAGIETSGFEMGRIADVFGFVEG
What is the function of this protein?
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
What are the official names of this protein?
Translation initiation factor 6, aIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
Protein: TGL_BACHK
Sequence: MIVIGRSIVHPYITNEYEPFAAEKQQILSIMAGNQEIYSFRTSDELSFDLNLRVNIITSALELFQSGFQFRTFQQSFCNPQYWKRTSLGGFELLPNIPPSIAIQDIFKNGKLYGTECATAMIIIFYKALLSLYEKETFNRLFANLLLYTWDYDQDLKLITKTGGDLVPGDLVYFKNPQVNPATIEWQGENTIYLGNFFFYGHGVGVKTKEEIIYALNERRVPYAFISAFLTDTITRIDSRLMSYHASPSTPQTSIGFIPIRDDAIVATVGNTTTVY
What is the function of this protein?
Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links.
What are the official names of this protein?
Protein-glutamine gamma-glutamyltransferase, Transglutaminase, TGase.
What is the protein family that this protein belongs to?
Belongs to the bacillus TGase family.
Protein: NEC2_RAT
Sequence: MEGGCGSQWKAAGLLFCVMVFASAERPVFTNHFLVELHKDGEEEARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKRQLERDPRIKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNSDASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANVDLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLQTNACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGLLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKQELEEELDEAVERSLQSILRKN
What is the function of this protein?
Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.  Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity).
What are the official names of this protein?
Neuroendocrine convertase 2, NEC 2, KEX2-like endoprotease 2, Prohormone convertase 2, Proprotein convertase 2, PC2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family. Furin subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Localized in the secretion granules.
Protein: PITA_ECOL6
Sequence: MLHLFAGLDLHTGLLLLLALAFVLFYEAINGFHDTANAVATVIYTRAMRSQLAVVMAAVFNFLGVLLGGLSVAYAIVHMLPTDLLLNMGSSHGLAMVFSMLLAAIIWNLGTWYFGLPASSSHTLIGAIIGIGLTNALMTGTSVVDALNIPKVLSIFGSLIVSPIVGLVFAGGLIFLLRRYWSGTKKRARIHLTPAEREKKDGKKKPPFWTRIALILSAIGVAFSHGANDGQKGIGLVMLVLIGVAPAGFVVNMNATGYEITRTRDAINNVEAYFEQHPALLKQATGADQLVPAPEAGATQPAEFHCHPSNTINALNRLKGMLTTDVESYDKLSLDQRSQMRRIMLCVSDTIDKVVKMPGVSADDQRLLKKLKSDMLSTIEYAPVWIIMAVALALGIGTMIGWRRVATTIGEKIGKKGMTYAQGMSAQMTAAVSIGLASYTGMPVSTTHVLSSSVAGTMVVDGGGLQRKTVTSILMAWVFTLPAAVLLSGGLYWLSLQFL
What is the function of this protein?
Low-affinity inorganic phosphate transporter.
What are the official names of this protein?
Low-affinity inorganic phosphate transporter PitA.
What is the protein family that this protein belongs to?
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS3_ECOSM
Sequence: MGQKVHPNGIRLGIVKPWNSTWFANTKEFADNLDSDFKVRQYLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSITSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEKPAAQPKKQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.