PharMolix/UniProtQA huggingface dataset:
Protein: RL11_CORDI
Sequence: MAPKKKVTGLIKLQIQAGQANPAPPVGPALGAHGVNIMEFCKAYNAATENQRGNVVPVEITVYEDRSFDFKLKTPPAAKLLLKAAGLQKGSGVPHTQKVGSVTMDQVKEIAQTKMEDLNANDIENAARIIAGTARSMGIEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ARAA_NOCSJ
Sequence: MTHHPDELEIWFLTGSQHLYGPEVIDQVAEHAARIVAALDASPHLPVRVVSKPVLTETDSIRRALLDATATDSCVGVIAWMHTFSPAKMWITGLDALRKPLLHLHTQANQALPWAEIDMDFMNLNQAAHGDREFASVQTRMGVARKTVTGHVEDPEVARRIGLWARAALGRHALAGMRLARFGDNMRNVAVTEGDKVEAERRFGVSVNTWGVNDLVAVVDEVADADVDKLCEEYADSYDVAAELLPSGERHESLRYGARIELGLRSFLTEGGFTAFTSNFEDLGGLRQLPGLAVQRLMADGYGFGGEGDWKTSVLLRTLKVVADGLPGGTSFMEDYTYHLVPGEERILGAHMLEVCPSIAEGRPSLEIHPLSIGGREDPVRLVFDAAPGPAVLLGLADLGERFRFVGNEVEVVAPTEPLPNLPVARAVWRPAPDLRTSTEAWLMAGGPHHTVLSTALGAEHLDDLAEMTGTELVLVDADTTIRGLAKELRWSAAYHRLAQGL
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: DGCQ_SALCH
Sequence: MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHLGSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDKRRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSCSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTANTLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLAKRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLADKRLYYAKQSGRNRICASDATQEREKK
What is the function of this protein?
Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity).  Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.  Involved in the regulation of cellulose production (By similarity).
What are the official names of this protein?
Probable diguanylate cyclase DgcQ, DGC, Cellulose synthesis regulatory protein.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL14_ECO24
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: APT_LEVBA
Sequence: MATDFTKYIASVPDYPEKGIMFRDISPLMADGQAFHAATDEIVAYAKDKDVEMVVGPEARGFIVGCPVAYEMGIGFAPARKEGKLPRETVKASYDLEYGQSALYLHKDAIKPGQKVLVTDDLLATGGTIGATIQLVEDLGGIVVGTAFLIELQDLHGRDKLKGYDIFSLMQY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR_PHOLL
Sequence: MSKVLVLKSSIMAQHSHTNQMADFFIEKWQTNHADDSITVRDLTAQSIPALDNELVHALRPSGNEMTARQKETLALSDELIAELQDNDVIVITAPMYNFHIPTQLKSYFDMIARAGVTFRYTENGPEGLLKGKQVIILTSRGGIHKDGPSDLLVPYLRLFLSFIGLTDIEFVFTEGVALGPDAANQAQQTAREVLQAIAS
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: PPE62_MYCTO
Sequence: MNYAVLPPELNSLRMFTGAGSAPMLAAAVAWDGLAAELGSAASSFGSVTSDLASQAWQGPAAAAMAAAAAPYAGWLSAAAARAAGAAAQAKAVASAFEAARAATVHPLLVAANRNAFAQLVMSNWFGLNAPLIAAVEGAYEQMWAADVAAMVGYHSGASAAAEQLVPFQQALQQLPNLGIGNIGNANLGGGNTGDLNTGNGNIGNTNLGSGNRGDANLGSGNIGNSNVGGGNVGNGNFGSGNGRAGLPGSGNVGNGNLGNSNLGSGNTGNSNVGFGNTGNNNVGTGNAGSGNIGAGNTGSSNWGFGNNGIGNIGFGNTGNGNIGFGLTGNNQVGIGGLNSGSGNIGLFNSGTNNVGFFNSGNGNLGIGNSSDANVGIGNSGATVGPFVAGHNTGFGNSGSLNTGMGNAGGVNTGFGNGGAINLGFGNSGQLNAGSFNAGSINTGNFNSGQGNTGDFNAGVRNTGWSNSGLTNTGAFNAGSLNTGFGAVGTGSGPNSGFGNAGTNNSGFFNTGVGSSGFQNGGSNNSGLQNAVGTVIAAGFGNTGAQTVGIANSGVLNSGFFNSGVHNSGGFNSENQRSGFGN
What are the official names of this protein?
Uncharacterized PPE family protein PPE62.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: AAEB_EDWTF
Sequence: MLHPRVIRLRFACKLTLAIVLSLLLGFYFGLQTPRWSALTAALVAAGPAFAAGGEPFAGAIRYRGWLRIIGTVLGSLCALLLMMLLIRAPLLMILLCCLWAGVCTWLSSLVRMENAYALGLSGYTALIIVVSCLGEPQFILQLALERCGEIVLGIACAVLADTLLAPRSVKGEVDRVVGGMLLGQLCLLQRCVDGRDSDAVDRSWHGLIRESHTLEGMRASLALESSRWPRACRRLAALHTLSLTLITRACEIFLTQRQTPTALPAPFLTLIAAPVKTPAEAYQRLKQLRRLLAAHGGHQLPPALIGWIDGASQLQLLAKGVASNVRIGRHEAAILAHDAAPRQIYSAQGHHALINGLRTWLATSLGALFWLWSGWNAGSGCMIMIAVVTSLAVRTPNPRMAAIDFLMGSLVALPVGALYYTVILPATQQSLVLLCLSLGALTFICGMEVQKRRLGSLGTLASTLNILVLSNPMRFPIESFVDSAIGQVIGCLLALVVLLAVRDRSRARTGRTLMRRLAFGAVAALRGEGTRGNLLPALYRQLFLLLTLFPDDIGRYRLALTLIVLQQRLAHSALPCDAERLRAIDAAATRLLTGRGAARRRGALLQLTTGLSDYADALVRQGAAGAALQPLHQLADVLHRYRGVLLG
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity).
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPSS_METM6
Sequence: MEINTDKYKNITRNLEREMINLNPIQRGGIIPTESKKIIYEYWDGYSVCDYCSGRLDKIETPPINEFLEDMSKFLGMDITRPTHGARESKYAVMNSVCKEGDYVVLDGNAHYTSYVALERAKLNYEKTDIEEYPTFRVIPESYAEKIDMLEDSKKNIGLILLTHVDGNYGNVADVKKVGKIAKSKGYPFLLNCAYSAGRMPIDGKKLNVDFIAASGHKSMAASGPCGLLSINKSYEDEVLETSKVNAVKELQMLGCTSRGIPILSLMASFEHLIERVKQWDLEVEKTRKVVNELEPLGFNQIGEKPRNHDIIRFETPILDEIAEKDKRRGFFFYEELKKRGIGGIRRGVTKEFKMSVYGLTNSQVDYVINSMKSIINELR
What is the function of this protein?
Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
What are the official names of this protein?
O-phospho-L-seryl-tRNA:Cys-tRNA synthase, Sep-tRNA:Cys-tRNA synthase, SepCysS.
What is the protein family that this protein belongs to?
Belongs to the SepCysS family.
Protein: HDHD2_PONAB
Sequence: MAACRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRGTSVIVRFVTNTTKESKQDLLERLRKLEFDISEDEIFTSLTAARSLLEQKQVRPMLLVDDRALPDFKGIQTTDPNAVVMGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGMLGILVKTGKYRASDEEKINPPPYLTCESFPHAVDHILQHLL
What are the official names of this protein?
Haloacid dehalogenase-like hydrolase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
Protein: GEMI6_SCHPO
Sequence: MDSHTTEKRRGSYLRVLFKNGRLPVEGFLWNCDPLTGTLILIQPLTPNTDEVEDTHYRFYGIMSDAIQTIEPDESMSPLNQQSLAEYDSLLTS
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:33754639).  Most spliceosomal snRNPs contain a common set of Sm proteins smb1, smd1, smd2, smd3, sme1, smf1 and smg1 that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity).  In the cytosol, the Sm proteins smd1, smd2, sme1, smf1 and smg1 (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone saf5 (By similarity).  To complete assembly of core snRNPs, the SMN complex accepts 5Sm from saf5 (By similarity).  Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of smd3 and smb1 to complete assembly of the core snRNP (By similarity).
What are the official names of this protein?
Uncharacterized protein new12.
Protein: ENO_CAMJR
Sequence: MLVIEDVRAYEVLDSRGNPTVKAEVTLSDGSVGAAIVPSGASTGSKEALELRDNDERFGGKGVLKAVANVNETIADEILGLDAFNQTQLDDTLRELDGTNNYSNLGANATLGVSMATARAAAAALGMPLYRYLGGANASILPVPMCNIINGGAHANNNVDFQEFMIMPFGFTSFKEALRSVCEIYVILKKELANSGHSTALGDEGGFAPNLANNTEPIDLLMTCIKKAGYENRVKIALDVASTEFFKDGKYHMEGKAFSSEDLIERYVELCAKYPICSIEDGLAENDFEGWIKLTEKLGNKIQLVGDDLFVTNEDILREGIIKKMANAVLIKPNQIGTITQTMRTVRLAQRNNYKCVMSHRSGESEDAFIADFAVALNTGQIKTGALARGERTAKYNRLLEIELESDEYLGEKL
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: DCVR_ORYSI
Sequence: MAALLLSSHLTAASSSSTTSPTARPAPSFVSFRAANAAPKGARRGWPFLASSVEPPPAASAAQPFRSLAPSETTVLVTGATGYIGRYVVRELLRRGHPVVAVARPRSGLRGRNGPDEVVADLAPARVVFSDVTDAGALRADLSPHGPIHAAVCCLASRGGGVRDSWRVDYRATLHTLQAARGLGAAHFVLLSAVCVQKPLLEFQRAKLRFEGELAAEASRDPSFTYSIVRPTAFFKSLGGQVETVKNGQPYVMFGDGKLCACKPISEEDLAAFIADCISDEGKANKILPIGGPGKALTPLEQGEMLFRLLGREPRFIKVPIQVMDAAIWVLDALAKVFPGVEDAAEFGKIGRYYASESMLVLDPDTGEYSDEMTPSYGSDTLEQFFERVIREGMAGQELGEQTIF
What is the function of this protein?
Catalyzes the conversion of divinyl chlorophyllide to monovinyl chlorophyllide.  Reduces the 8-vinyl group of the tetrapyrrole to an ethyl group using NADPH as the reductant.  Can use (3,8-divinyl)-chlorophyllide a (DV-Chlidea) > (3,8-divinyl)-chlorophyll a (DV-Chla) > (3,8-divinyl)-protochlorophyllide a (DV-Pchlidea) > (3,8-divinyl)-magnesium-protoporphyrin IX monomethyl ester (DV-MPE) > (3,8-divinyl)-magnesium-protoporphyrin IX (DV-Mg-Proto) as substrates.
What are the official names of this protein?
Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HBA_CATCL
Sequence: SLSDKDKADVKIAWAKISPRADEIGAEALGRMLTVYPQTKTYFAHWADLSPGSGPVKHGKKVIMGAIGDAVTKFDDLLGGLASLSELHASKLRVDPSNFKILANCITVVIMFYLPGDFPPEVHASVDKFFQNLALALGQKYR
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: Y3613_BACHK
Sequence: MAMRFLNIGYGNIVSAHRIIAIVSPESAPIKRTVQEAREHNALLDATYGRKTRAVIVMDDGHVVLSPIQPETIAHRLNNKEDLSEEG
What are the official names of this protein?
Putative regulatory protein BT9727_3613.
What is the protein family that this protein belongs to?
Belongs to the RemA family.
Protein: TRPI_PSESY
Sequence: MSRDLPPLNALRAFEATARLNSVSQAAEQLHVTHGAVSRQLKVLEEHLGISLFVKDGRGLKLTDAGARLRDASAEAFERLRDVCAELTQSSADAPFVLGCSGSLLARWLIPRLGRLNADLPDLRLHLSAGDGDLDPRRPGLDALLVFAEPPWPADMQVYELTSERIGPVMSPRFAGYERLSHAPAAALCGEALLHTTSRPQAWPSWAQQHGIEPGALKHGQGFEHLYYLLEAAVAGLGVAIAPEPLVAEDLRAGRLVAPWGFSETPAHLALWLPNARRDGRAGQLAQWLKAELLRQPY
What is the function of this protein?
Activates the expression of the trpBA genes, which encode the two tryptophan synthase subunits, and represses initiation at its own promoter.
What are the official names of this protein?
HTH-type transcriptional regulator TrpI, TrpBA operon transcriptional activator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: TKTL1_HUMAN
Sequence: MADAEARAEFPEEARPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVLFFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRVFCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRERADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALAKLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFASTFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCMLLN
What is the function of this protein?
During fetal neocortex development, may be essential to maintain the full number of basal radial glia (bRG).  bRG are neural progenitor cells that undergo asymmetric divisions, generating a bRG (self-renewal) and a neuron, in contrast to basal intermediate progenitors (bIPs), which typically divide once to give rise to 2 neurons.  bRG generate more cortical neurons over time than bIPs.
What are the official names of this protein?
Transketolase-like protein 1, Transketolase 2, TK 2, Transketolase-related protein.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic and to a lesser extent also nuclear (PubMed:16969476).
Protein: NS3A_CVPPU
Sequence: MDIVKSIYTSVDAVLDELDCAYFAVTLKVEFKTGKLLVCIGFGDTLLAAKDKAYAKLGLSIIEEVNSHIVV
What are the official names of this protein?
Non-structural protein 3a, ns3a, Accessory protein 3a, X2a protein.
Protein: ACPM_MYCTO
Sequence: MPVTQEEIIAGIAEIIEEVTGIEPSEITPEKSFVDDLDIDSLSMVEIAVQTEDKYGVKIPDEDLAGLRTVGDVVAYIQKLEEENPEAAQALRAKIESENPDAVANVQARLEAESK
What is the function of this protein?
Acyl carrier protein involved in meromycolate extension.
What are the official names of this protein?
Meromycolate extension acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_GEODF
Sequence: MRLIVAGGGTGGHLFPGIAVAEEFLARNSANEVLFIGTERGIEARLLPKLGYRLECISASGIKGQSPLTKVKSAALLLYGYSQSRKILKEFRPDVVLGVGGYASAPVVLSARGLQIRRFIHEQNAIPGLTNKVLARIADKVFISIEESRKFFPEDRTMLTGNPLRKEILWNVQQGKTEPKGGSLRLLVFGGSAGAHRINTAMVEALPHLAKVKEHLLITHQTGEKDHGEMKKAYGAAGFNAEVTPFIDNMAAAYAAADFIVCRAGATTLAEVAVSGKACIFIPYPYAADDHQRRNAEALLKEDAGFMILERELTGDTLAGQIIRLMQEPELVEKTAANIRKFGQLDAAQVIVDEMTGKQEPLCTEK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YL326_YEAST
Sequence: MSGFIKSTLLGLGQDYLEDQYQEFAEQHFQPTRDPFYETNKDGKKHRRRLPYYCTKDESKAWKKVQNKAWLHDKSLCGCCCWTNTIGWAPLLALLPVIGPLLMYWVHDKLIELADDRYKLPAEIKVKMHGNIVIDLLISLVPILGSVFAWLHACSTRNAAIVYNFVGKRALERKQAELMHQKEENEKHSNANTAPPVVGGNKNVNGNRNNSKMYNRPPVTAPPAPAYTRSTNGRPQRGYR
What are the official names of this protein?
Uncharacterized membrane protein YLR326W.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ACP_CHLAA
Sequence: MASPEMEERLRKIIVDQLGVEPEQVVPSASFTKDLNADSLDLVELIMSIEEEFGVEISDEEAEKIQTVADALNYLETHQSNE
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYUG_HUMAN
Sequence: MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAEEAQSGGD
What is the function of this protein?
Plays a role in neurofilament network integrity.  May be involved in modulating axonal architecture during development and in the adult.  In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity).  May also function in modulating the keratin network in skin.  Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
What are the official names of this protein?
Gamma-synuclein, Breast cancer-specific gene 1 protein, Persyn, Synoretin, SR.
What is the protein family that this protein belongs to?
Belongs to the synuclein family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
Protein: RIMM_STAAS
Sequence: MRVEVGQIVNTHGIKGEIKVKSNSDFTDVRFQPGQVLTVVHNNNDLEYTVKSHRVHKGLHMLTFEGINNINDIEHLKGSSIYQERDHEDIVLEENEFYYSDIIGCTVFDDQETPIGRVINIFETGANDVWVIKGSKEYLIPYIADVVKEVDVENKKIIITPMEGLLD
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQO1_SCHPO
Sequence: MMSNENFDNDYNLPPPNDSAEDLKIFIKRYERSVDSTLLEIDENKREALEKYIEERDRKMKYEIECNERLQGWKKLAIEREISEEQSGEVQFPRWIDEWANTKLGGIFERIFSKMDSMQNDMNSRFDAMQNEMNSRFDAVQNEMTSMKGEMAEMKVEMVEMKRETIRLNTRIDLLEQKTEARFQSIEQRFNSIDQRFNSIDRRFDSMEQRLDSMDQKMETIDARSCRSIMLTRKLENTTRSDQGYLASPVPFLNGNEPANSGLPPIERVEDIDELSKEQCVQYLKGYGIMFSPAETIKLKKRLRDAVGLWSKASTEYEFHQFH
What are the official names of this protein?
UPF0612 protein C569.01c.
What is the protein family that this protein belongs to?
Belongs to the UPF0612 family.
Protein: RL20_SALEP
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: MYOC_HUMAN
Sequence: MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRELGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM
What is the function of this protein?
Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration.  Promotes substrate adhesion, spreading and formation of focal contacts.  Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.  Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways.  Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling.  Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling.  Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling.  Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex.  Involved in positive regulation of mitochondrial depolarization.  Plays a role in neurite outgrowth.  May participate in the obstruction of fluid outflow in the trabecular meshwork.
What are the official names of this protein?
Myocilin, Myocilin 55 kDa subunit, Trabecular meshwork-induced glucocorticoid response protein.
What are the subcellular locations of this protein?
Secreted. Golgi apparatus. Cytoplasmic vesicle. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Secreted, extracellular exosome. Mitochondrion. Mitochondrion intermembrane space. Mitochondrion inner membrane. Mitochondrion outer membrane. Rough endoplasmic reticulum. Cell projection. Cell projection, cilium. Note=Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum (PubMed:9169133). It is only imported to mitochondria in the trabecular meshwork (PubMed:17516541). Localizes to the Golgi apparatus in Schlemm's canal endothelial cells (PubMed:11053284). Appears in the extracellular space of trabecular meshwork cells by an unconventional mechanism, likely associated with exosome-like vesicles (PubMed:15944158). Localizes in trabecular meshwork extracellular matrix (PubMed:15944158). SUBCELLULAR LOCATION: [Myocilin, C-terminal fragment]: Secreted. SUBCELLULAR LOCATION: [Myocilin, N-terminal fragment]: Endoplasmic reticulum. Note=Remains retained in the endoplasmic reticulum.
Protein: RBFA_GLOC7
Sequence: MATDRRVSRVSSLIKREVSQMLLHGIKDDRVGAGMVSITDVDVSGDLQHAKIFVSIYGTEQAKAETMEGLKSSVGFVRRELGQRIRLRRTPEVVFLEDTSLERGDRTLHLLNQLQDARKEEDEYIEPAQDD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENG_TROWT
Sequence: MGTNIHIDMVIHGKHTAEIRKMFNRVAQAYDRTNLVLSFLQDAHWRRAACKMLGVTAGEEVLDVGAGTGASTRTVARTGAAVTGIDISPRMLQIARNRCKRFQNITWRLTNGDLPFPDKSFDAILMVFCLRNVSNIQGFLCDAARVLKPGGRLVVCEFSHPRRFVAPFYRLYLRYVLPRLAKLISSDPAAYEYLTESIEDWYEVDELAFMLEQCGFQNTSWKRLSFGAVALHRALRGPE
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.