PharMolix/UniProtQA huggingface dataset:
Protein: GPC3_HUMAN
Sequence: MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH
What is the function of this protein?
Cell surface proteoglycan (PubMed:14610063).  Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity).  Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity).  Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449).  Positively regulates the non-canonical Wnt signaling pathway (By similarity).  Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity).  Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790).  Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity).  Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity).  Required for coronary vascular development (By similarity).  Plays a role in regulating cell movements during gastrulation (By similarity).
What are the official names of this protein?
Glypican-3, GTR2-2, Intestinal protein OCI-5, MXR7.
What is the protein family that this protein belongs to?
Belongs to the glypican family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Protein: ALR_STRCO
Sequence: MSETTARRDADAVLRARAEIDLAALRANVRALRERAPGAALMAVVKADAYGHGAIPCARAAVAAGATWLGTATPQEALALRAAEPGLPDDVRIMCWLWTPGGPWREAVEARLDVSVSAMWAMEEVTGAARAAGVPARVQLKADTGLGRGGCQPGADWERLVGAALRAEEEGLLRVTGLWSHFACADEPGHPSIAAQLTRFREMTAYAEQRGLRPEVRHIANSPATLTLPDAHFDLVRPGIAMYGVSPSPEIGTPADFGLRPVMTLAASLALVKQVPGGHGVSYGHHYTTPGETTLGLVPLGYADGIPRHASSSGPVLVDGKWRTVAGRIAMDQFVVDLGGDRPEPGAEAVLFGPGDRGEPTAEDWAQAAGTIAYEIVTRIGSRVPRVYVNE
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: NUOCD_BDEBA
Sequence: MNKLENLKQLLAGKFKIENFKFTHAVGDDVIEVPKEDAPALLLFLRESGQFDFLMDVCGADYPSREKRFDVVYNLFNSKDSSRLRVKAQVGEGESIGTAIPAYRGADWFEREAYDMFGIIFEGHPNLRKILTHHQFVGHPLRKDYDANNQQACTNSLPIHFNNEPGSPGDVLNDKYLPLNIGPSHTAMHGTLRVMAEMDGETIVRCNNEIGYLHRCFEKMAETHPYNQVIPYTDRLNYCSAPMNNIGYCKAVERLLGVEIPPKAQAMRVILAELSRIIDHTIAIGTGAMDLGALTSFFYMFGMREKVYGLFEKLCGARLTVSMTRIGGMAQDAPEGWFDEVLALVKEIRKGTDEMANMVIDNKIFIQRTKNVCPVSAADAIQWGYTGPMLRACGVNLDLRKAQPYYGYDALDFDVPVGTNGDIYDRYLVRFEEMRQSVRIIEQVCKNVPGGDYTIRDKGIVLPEKKDVYGNIEGLMNHFMLIIKGLRPPVGEVYDATEAANGELGFYLVSDGSANPYRLKVRPPCFAIYQSFPTVVKGAMLADAIATVASMNLIAGELDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D, NUO3/NUO4.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: DFP1_LONON
Sequence: MMFIYVVALVSAVAFTDAFPTGAPVSACFDMIPGHGTDPKPPPAPYTIGAVANSVKAGKSVEVVISGKTPEDTMLGILLEARQGDKIVGTWNVAPDDDFAQLLDCGAPGNAVTHKHVPNKQPKQTVSYVWNAPADGEGDVTFLVTIVKKYDTFWVKVSSAPIQIVHAH
What is the function of this protein?
May have antimicrobial activity.
What are the official names of this protein?
Putative defense protein 1, DFP-1.
What is the protein family that this protein belongs to?
Belongs to the insect defense protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMB_POLNA
Sequence: MIESSSPTPPALHEGAPADVSHPRNIRSFVRRTGRTTVGQAKAFADVGPRFLLAYSGLPMDFSAVYGRDAPTILEIGFGMGEATAHIAGLMPEKNFLCCEVHTPGVGALLKRIDEQALTNIRILQHDAVEVIDHMLPLGSLDGAHIFFPDPWHKTKHNKRRLIQAPLIAKLAARLKPGGYLHCATDWQPYAEQILEVLSAEPLLKNTADAASDGYAPKPGYRPLTKFENRGIKLGHGVWDVVFTRA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RS3A_PARBD
Sequence: MAVGKNKRLSKGKKGLKKRTQDPFSRKDEYSVKAPSTFAIRDVGKTLVNRTTGLKNANDALKGRIFEVSLADLQNDEDHAFRKVKLRVDEVQGKNCLTNFHGLDFTSDKLRSLVRKWQTLIEANVTVKTTDDYLLRLFAIAFTKRRPNQIKKTTYAQSSQIRAIRKKMVEIIQREAGTRSLAQLTKLIPEVIGREIEKATHGIYPLQNVHIRKVKLLKSPKFDLGALLALHGESSTDDKGQKVEREFKETVLESV
What are the official names of this protein?
40S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DB134_HUMAN
Sequence: MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLECCVKGNPAP
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 134, Defensin, beta 134.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FRDD_ECOLI
Sequence: MINPNPKRSDEPVFWGLFGAGGMWSAIIAPVMILLVGILLPLGLFPGDALSYERVLAFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTLIGVVTI
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones (PubMed:10373108).  The QFR enzyme complex binds 2 quinones in or near the membrane; 1 near the [3Fe-4S] cluster (QP is proximal to the [3Fe-4S] cluster, on the cytoplasmic side of the membrane) while QD (the distal cluster) is on the other side of the membrane.  It is not clear if both of the quinol-binding sites are functionally relevant (PubMed:10373108, PubMed:11850430).
What are the official names of this protein?
Fumarate reductase subunit D, Fumarate reductase 13 kDa hydrophobic protein, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIG1B_HUMAN
Sequence: MSANRRWWVPPDDEDCVSEKLLRKTRESPLVPIGLGGCLVVAAYRIYRLRSRGSTKMSIHLIHTRVAAQACAVGAIMLGAVYTMYSDYVKRMAQDAGEK
What are the official names of this protein?
HIG1 domain family member 1B, Protein CLST 11240.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RT04_DICCI
Sequence: MRIRKNITKFIKRAYIDMGELKQVKGYTKTRLNIISNKVFLLKQELYPLKKQKKVGKLKKKRVTTYTRKKLKRILSLLFRIGGKIYRRKIKKKKINLKKKEEHFTNNLILYRLFRKFYINLKLKQFKRLYKKYKGNEKIIIQQLEKRIDMILLRSGFVRSIYEARQLINHKHILVNGNIARIPSYTLNVGDIISIKEGSHKQNLIHRLKKILLPKVVPEHKKNLIHRFVSKGMDKYKYNYKQKYQPNDKAKYQQNYKYQAKRRRESKKKRRIRATGPKYLEISHALLLISLIEEPKLTAIKYPFTLQPENNIKFISLLNKYKRIR
What are the official names of this protein?
Ribosomal protein S4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: F199X_DANRE
Sequence: MSEGVYEKFLAPEEPFPLLSQRGNFSEDATLDVSDFGCQLSSCHRTDPLHRFHSSRWNLTSCGTSVASSECSEELFSSVSVGDQDDCYSLLDDQELTSFDLFPEGSVCSDVSSSISTYWDWSDSEFEWQLPGSDIASGSDVLSDIIPSVPSSPCLVSKRKSKPHRNLDELPWSAMTNDEQVEYIEYLSRKVSTEMGLREQLDIIKIIDPSAQILPTDSEFIIELNCLTDEKLKQVRSYIREHSPRQRPNITRDNWKRSMASNGSTSGVSAHSSSNASMVSSTSSSTASTGSNSSTNISRAHSDGNLATAAERIRDSKKRSKQRKMQQKALRKRQLKEQRQARKERLSGLFMNEEVLSLKVTEEEDHCDDVDVLM
What are the official names of this protein?
Protein FAM199X.
What is the protein family that this protein belongs to?
Belongs to the FAM199 family.
Protein: ATPB_MESFL
Sequence: MAAKKTTSKNTVNSANGFVFQILGPVVDVKFSEDNIPMIYDALVVDNNGVELVLEVEQHMGDEVVRTIAMGPTEGLAKGLPVINTNAPILAPVGDDVLGRMFNVTGHAIDEKPEFTGKRMPIHRDAPAYEELITNAEILETGIKVIDLMIPFAKGGKIGLFGGAGVGKTVLIQELINNIAKAHSGVSVFAGVGERTREGNDLYHEFIEAGVLDKTSLVFGQMNEPPGARMRVALTGLTIAEHFRDEKNMDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTNKGSITSVQAVYVPADDLTDPAPATTFTHLDAKIVLDRSIASLGIYPAVDPLSSSSRMLDPEIIGEEHYNVALGVQGTLQKYQDLQSIIAILGMDELSAEDKLIVQRARKIRNFLSQSFYVGEKFTGRPGQYVKVSDTVRSFKMILDGEMDDIPEILFLYKGTAEDVIQAYNETKVKNKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: S12A2_MOUSE
Sequence: MEPGPARPRLAPAARPGWGRAAGCRRRGGPARHGRASGQEDATTAGRQAGGGVRGEGTPAAGDGLGRPLGPTPSQSRFQVDPVSENAGRAAAAAAAAAAAAAAAGAAGKETPAAGKAGGESGVAKGSEEAKGRFRVNFVDPAASSSADDSLSDAAGVGGDGPNVSFQNGGDTVLSEGSSLHSGGGSGHHQQYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVAYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIADFVIGTFISLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTVVYIGIAVSVGSCVVRDATGNVNDTITTELTNCTSAACKLNFDFSYCESNTCSYGLMNNFQVMSMVSGFAPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQARYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQFGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVNVDYSKKSDQDTCKSSGEKSITQKDEEEDGKTPTQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFDDMIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPVLLVRGNHQSVLTFYS
What is the function of this protein?
Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:32658972).  Plays a vital role in the regulation of ionic balance and cell volume.
What are the official names of this protein?
Solute carrier family 12 member 2, Basolateral Na-K-Cl symporter, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein.
Protein: ATPG_BACP2
Sequence: MASLRDIKSRITSTKKSSQITKAMQMVSAAKLNRAENNAKSFVPYMEKIQEVVAAIATGTSAKHPMLLSRPVKKTGYLVITSDRGLAGPFNSSILRAAYQTIQSRHQSADEYAVIVIGKIGRDFFKKRGIPVISEVTGLGDEVAFADIKELASSTVQMFSDEAFDELYMFYNHFVSAISQEVTEKKLLPLTDISAAATPNKRSASYEFEPSEEEILEVLLPQYAESLIFGALLDSKASEHAARMTAMKSATDNAKELIDSLTLSYNRARQAAITQEITEIVGGAAALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CYB_MYORP
Sequence: MTNIRKSHPLMKIINSSFIDLPAPSNISSWWNFGSLLGICLGLQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWVLRYLHANGASMFFICLYLHVGRGLYYGSYMYTETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIIAAMVMVHLLFLHETGSNNPTGIPSNADMIPFHPYYTIKDILGLLLMIMVLLTLVLFSPDLLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILIIIPLLHTSKQRSMTFRPLSQCLFWLLAADLFTLTWIGGQPVEHPYVIIGQLASILYFSIIIILMPLTSLMENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ASTD_SALPC
Sequence: MTLWINGDWITGQGERRRKTNPVSAEILWQGNDANAAQVAEACQAARAAFPRWARQPFTARQAIVEKFAVLLEAHKADLTEVIARETGKPRWEAATEVTAMINKIAISIKAYHARTGEQKSELVDGAATLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTLIFKPSELTPWTGETVIKLWERAGLPAGVLNLVQGGRETGQALSSLDDLDGLLFTGSASTGYQLHRQLSGQPEKILALEMGGNNPLIIEDVTNMDAAVHLTLQSAFITAGQRCTCARRLLVKQGAQGDAFLARLVDVAGRLQPGRWDDDPQPFIGGLISAQAAQHVMEAWRQREALGGRTLLAPRKVKEGTSLLTPGIIELTGVTDVPDEEVFGPLLNVWRYAHFDEAIRLANNTRFGLSCGLVSTDRAQFEQLLLEARAGIVNWNKPLTGAASTAPFGGVGASGNHRPSAWYAADYCAWPMASLESPELTLPATLSPGLDFSRREAV
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: RL27_STAA2
Sequence: MLKLNLQFFASKKGVSSTKNGRDSESKRLGAKRADGQFVTGGSILYRQRGTKIYPGENVGRGGDDTLFAKIDGVVKFERKGRDKKQVSVYAVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: ALR_XYLFT
Sequence: MCSVRPAHAVIDLDALRHNYRFARRLGGGKALAVVKADAYGHGAVRCAQALEAEVDGFAVACIEEALELRQAGIQAPILLLEGFFEVEELELIAKHNLWTVIASSWQVRALAAFHSPSPIGVWLKLDSGMHRLGLEPKEFRDAWMSLHSLPQVGEVVLMTHLARADELDNPRTNEQASVFAHASQGMVAPASVCNSSGLLGWAGLYSDWGRPGLMLYGVNPISQESTSLSGPLRPVMMVYSKLIAVRELPAGEPVGYGASFVTERPTRVGVVAMGYADGYPYFAVNGTPLLVDGRVCPLIGRVSMDMLTVDLTDHPQADVGSQVQLWGVQPGVAELAAHCNLSAYQLLCGLKRVRRYYLGEMGAV
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: THS2_HALVD
Sequence: MSQRMQQGQPMIIMGEDAQRVKDRDAQEYNIRAARAVAEAVRSTLGPKGMDKMLVDSMGDVTITNDGVTILKEMDIDNPTAEMIVEVAETQEDEAGDGTTTAVAIAGELLKNAEDLLEQDIHPTAIIRGFNLASEKAREEIDDIAERVDPDDEELLKKVAETSMTGKSSELNKELLADLIVRAVRQVTVEANDGSHVVDLENVSIETQTGRSASESELLTGAVIDKDPVHDDMPVQFDEADVLLLNEPVEVEETDIDTNVSIESPDQLQKFLDQEEAQLKQKVDQIVDSGADVVFCQKGIDDLAQHYLAKQGILAVRRTKKSDIRFLKNITGAAVVSDLDSIEAAVLGRASVRRDEAGELFYVEGIGDDVHGVTLLLRGSTDHVVDELERGVQDALDVVASTVADGRVLAGGGAIEVELASRLRNYADSVSGREQLAVEAYADALELVPRVLAENAGLDSIDTLVDLRAAHEDGQVRAGLNVFTGEVEDAFDAGVVETAHAKEQAVASASEAANLVLKIDDIIAAGDLSTGGDDDEEGGAPGGMGGMGGMGGMGGAM
What is the function of this protein?
Molecular chaperone that assists in the folding or refolding of nascent or denatured proteins along with ATP hydrolysis (Probable).  ATPase activity is highest in thermosome assemblies containing CCT1:CCT2, followed by assemblies containing CCT1:CCT2:CCT3.  Seems to contribute to thermosome ATPase activity.  Not required for growth.
What are the official names of this protein?
Thermosome subunit 2, Heat shock protein CCT2.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
Protein: RIPA_PHYAM
Sequence: MKMMVVVVVMMLSWLILKPPSTWAINTITFDVGNATINKYATFMKSIHNQAKDPTLKCYGIPMLPNTNLTPKYLLVTLQDSSLKTITLMLKRNNLYVMGYADTYNGKCRYHIFKDISNTTERNDVMTTLCPNPSSRVGKNINYDSSYPALEKKVGRPRSQVQLGIQILNSGIGKIYGVDSFTEKTEAEFLLVAIQMVSEAARFKYIENQVKTNFNRAFYPNAKVLNLEESWGKISTAIHNAKNGALTSPLELKNANGSKWIVLRVDDIEPDVGLLKYVNGTCQATYQSAMFPHL
What is the function of this protein?
Inhibits viral infection of plants, and protein synthesis in vitro.  Has also been shown to inhibit the replication of mammalian viruses.  The protein may provide a means of cellular suicide upon invasion by a virus.
What are the official names of this protein?
Antiviral protein alpha, PAP-alpha, Ribosome-inactivating protein, rRNA N-glycosidase.
What is the protein family that this protein belongs to?
Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RIBL_NATPD
Sequence: MRRVVAQGTFDLLHPGHLYYLTEAKSMGDELHVIVARSQNVTHKQPPIVPDEQRREMVAGLDPVDSARLGHTDDFFVPIRDIDPDVIVLGHDQHHDDERLAEMLTEEGIDCEVARASARDGDDKILSTGRIVDRICEERC
What is the function of this protein?
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
What are the official names of this protein?
FAD synthase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase.
What is the protein family that this protein belongs to?
Belongs to the archaeal FAD synthase family.
Protein: ATPD_ECOHS
Sequence: MSEFITVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENGQNLIRVMAENGRLNALPDVLEQFIHLRAVSEATAEVDVISAAALSEQQLAKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: COFI_KLULA
Sequence: MSRSGVAVADESLNAFNDLKLGKKYKFILYALNDSKTEIIVKETSAEQDYDKFLEQLPENDCLYAVYDFEYELGNNEGKRSKIVFFTWSPDTAPVRSKMVYASSKDALRRALNGVSSDIQGTDFSEVAYESVLEKVSRAAGSH
What is the function of this protein?
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner.  It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin.  Binding to F-actin is regulated by tropomyosin.  It is the major component of intranuclear and cytoplasmic actin rods.  Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends.  In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments.  Involved in the maintenance of the contractile ring once formed.  In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton (By similarity).
What are the official names of this protein?
Cofilin, Actin-depolymerizing factor 1.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Note=Throughout the cytoplasm (but not on the cytoplasmic cables) and major component of the cortical actin cytoskeleton.
Protein: FABZ_NITOC
Sequence: MDTLDIHEILKHLPHRYPFLLIDRVIECIPGKSLVAIKNVSYNEPYFQGHFPGLPIMPGVLILESLAQATGILAFKTTETMPSEEAIYYFAGIDRARFKRPVGPGDQMRLEVELVRSLRRLWKFTGRVTVDGSLVASAEVMCSYQETYK
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_PROM9
Sequence: MIENQSDNIDIKENDVLNQDNAPEDNSSAAEKTIENDELSPQKTEEINTEELKNTISNNDARLEQLEKEHETLKNQYVRISADFDNFRKRQSRDQDDLKVQLVSKTLTAILPIVDNFERARQQLKPESEEAQALHRSYQGLYKQLVEVLKQQGVSPMRVVGQQFDPNLHEAVLREPSEEFKEDLIVEELQRGYHLEGKVLRHALVKVSMGHGQQNSQEEVEKDTVEEDIDSEENTSEDV
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECHA6_MYCLE
Sequence: MIGITQAEGVMTIELQRPERRNALNSQLIEKLREAVQKASSADSEVSTRVIVLTGQGTVFCAGADLSGDAFAADYPDRLIELHRVMDAVPMPVIGAINGPAIGAGLQLAMQCDLRVVAPDAYFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLTAEKLTADIALQTGMANRIGALADAQAWAAEVTGLAPLAIQHAKRVLNDDGSIEEAWPEHKKLFDKAWTSQDVIEAQVARVEKRPPKFQGA
What is the function of this protein?
Could possibly oxidize fatty acids using specific components.
What are the official names of this protein?
Probable enoyl-CoA hydratase echA6.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.