PharMolix/UniProtQA huggingface dataset:
Protein: SPEH_LEPIN
Sequence: MNALGKHVIAEFYECDYETINNHELVEDIMLKSVDLSGATTIKSVFHRFSPYGVSGVVVVSESHFAIHTWPEYGYCAVDVFTCGDLIDNQAALDYLKEKFGSKNVSVVEMKRGVLNLGVDLHHKPVGN
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: SIDT2_HUMAN
Sequence: MFALGLPFLVLLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGMFQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEQFSFNTTAAQPQYFKYEFPEGVDSVIVKVTSNKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFAEDEPVDQGHRQKTLSVLVSQAVTSEAYVSGMLFCLGIFLSFYLLTVLLACWENWRQKKKTLLVAIDRACPESGHPRVLADSFPGSSPYEGYNYGSFENVSGSTDGLVDSAGTGDLSYGYQGRSFEPVGTRPRVDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSIIHIIATLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNVINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF
What is the function of this protein?
Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365).  Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980).  In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA.  Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity).
What are the official names of this protein?
SID1 transmembrane family member 2.
What is the protein family that this protein belongs to?
Belongs to the SID1 family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Cell membrane. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (PubMed:28277980). Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (By similarity).
Protein: MPP8_RAT
Sequence: MAAATEENMSVAALVMSVPDNIGRSPEVEGGGAAGEEKDAATKGTVAVGDSEEDGEDVFEVERILDMKCEGGKNLYKVRWKGYTSDDDTWEPEVHLEDCKEVLLEFRKKVAENKAKAVRKDIQKLSLNNDIFEADSDIDQQGDTKEDTSPRKKKKKIKYKEDKSPDDLRKKRAKMGKLKDKFKTELESTSEILGFDVKTKKRILEVKEELKDSKKPKKDEIKETKKTKRADIRDLKIKIREDVKDNRKTKKERYIDSPLESESPNDSFTLEDESEDFLSDNKEKQNVRTAKDKTGQDTVQESIFEKHLDDLISIEEAGTRVRRKKKQPRKFEEPKEIKKLENTNNFLERKMIPKKQRNQDKGRSNPELSKLPSPVFAQTMKSLRLSGEEKGLKSSDLAEEEKERKNEPKEKYQKRYDFDKEEKARKEPKGLKSFKEIRNAFDLFKKTAEEKNDLENNSKREEISLDYKITHDNKTKDKCSLREERNTRDETDTWAYIAAEGDQEVSDSVCQTDESSDGKQPILSLGMDLQLEWMKLEDFQKHLDGEDEPFITANRIPSNLLRDAVKNGDYIAVKVALNSNEEYNLDQEDSTGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALYFAKQCNNVLVYELLKSHLETLSRVAEETIRDYFESRLALLEPVFPIACHRLCEGPDFSTDFNYMPPQNMPEGSGVLLFIFHANFLGKDVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPFAKVKLLIGAYRVQLQ
What is the function of this protein?
Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression.  Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2.  Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene.  Mediates down-regulation of CDH1 expression.  Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark.  Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression.  The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed.
What are the official names of this protein?
M-phase phosphoprotein 8.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Detected on heterochromatin. Dissociates from chromatin during interphase and early mitosis. Detected on nucleosomes.
Protein: NADB_LISIN
Sequence: MTKERVIIIGSGIAGCTAALRLMQDYDVTIITKGHKEQSNSMLAQGGVAAAISKSDTPKKHFSDTFQAGCFHNKVRAVNQLVTCGPIVIQKLINEGMTFDEKDGELSLGLEGAHQLPRILHSGGDQTGKFLTTFLQEKLTKVNWQEQKMAIEIIKHDGRAIGVHCLDKENQLHTYYGEHIILASGGLGQLFPVTTNAATISGDGLALAYRADATLSDMEFIQFHPTLLFLNGRCHGLISEAVRGEGATLIRADGSAIMETVHPLADLAPRDVVAATLFEEIERGNQVFLDITKVAHFEKRFPAITTSLDEHQVPFRETKRIPVHPGAHFLMGGVRTDLNGKTNIPHLYAIGEVANTGVHGANRLASNSLLETLVFGEKVAEYIHTQKNNRIIAPENPPTYQTTMPHLPEKHILQEKIWETLGITRKPEKITEFLHWLETFDYANHTRETAEISHMIITSKLIAESALKRTESLGAHRILKGVTK
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase, LASPO, Quinolinate synthase B.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_LISMC
Sequence: MIEIEKPKIETIEISDDAKYGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVTSIQIDGALHEFSVIEGVVEDVTTMILNIKKLALKIYSDEEKTLEIDMQGPGVVTAADINYDSDVEILNPDLHIATLSDNAKFHVRLNATRGRGYTPADQNKRENMPIGVLPVDSIFSPVIRVNYQVENTRVGQSTNYDKLTFDVLTDGSISPEEAVSLGAKILSEHLSIFVNLTDEAQKAEIMIEKEESHKEKVLEMTIEELDLSVRSYNCLKRAGINTVQELADKSEDDMMKVRNLGRKSLEEVKVKLADLGLSLRNEN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: MEP5_TRIRU
Sequence: MHGLLLAAAGLLSLPLHVVAHPQPSTSLAGRGVDLDAYRMADRSSYMSSDDMKLKQPAIASLSGGNYVDTATEVVKRMMPGMTFRMADDHYVGESGISHLYFRQTMHGMDIDNADFNVNIGKDGKVLSFGHSFYTGPAPDRAPVEKRDFSGPMRAFHGACKALNLPINADKATIQTMNEHEVMFVGTSGAMSDPQGKLCYMAKEDGTLALTWRVETDMGDNWLLSYVDAKETDKVHNVVDYVSHATYQVYRWPIPDPTEGKREIVENPWNLKTSPFTWISDGKTNYTTTRGNNAIAQANFDGGEDYLNNYRPNSKNLKFEYPYAPNMSPPKSYIDASVTQLFYSANIVHDLYYMLGFTEKAGNFQVNNHGQGGKGNDFVILNAQDGSGTNNANFATPPDGKPGRMRVYIWTKAKPARDSSFEAGTVIHEYTHGLSNRLCGGPANSGCLNGMESGGMGEGWGDFFATAIRLKPNDNRNANYVHGEWVNNSPKGNRLYPYSTNLQTNPLVYTSCNKYNEVHAIGTVWCSILYEVLWNLIDKHGKNDGPTPVFENGVPNDGKYLAMKLVLDGMAIQPCKPTFVQARDAIIDADMNLTKGSNKCELWKAFAKRGLGVGAKYDPKNRTGSKAVPKECQ
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 5, Fungalysin MEP5.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: OHR_XANAC
Sequence: MASPEKVLYTAHATATGGREGRAVSSDKALDAKLSTPRELGGAGGDGTNPEQLFAAGYAACFIGAMKAVAAQDKLKLPGEVSIDSSVGIGQIPGGFGIVVELRIAVPGMDKAELQTLVDKAHQVCPYSNATRGNIDVTLTLA
What is the function of this protein?
Organic hydroperoxide detoxification protein.  Confers increased resistance to tert-butyl hydroperoxide killing (By similarity).
What are the official names of this protein?
Organic hydroperoxide resistance protein.
What is the protein family that this protein belongs to?
Belongs to the OsmC/Ohr family.
Protein: EFTS_THEP3
Sequence: MISAQAVKELRERTGAGMMDCKKALMEANGDMEKAIDILREKGLAAAAKKAGRVANEGLVDAYIHSGGRIGVLVEVNCETDFVANTDEFKNFVKEICMQIAAANPKYISREDVPQAVLEKEREILKAQALNEGKPQNVVDRIVEGRIEKFYKENCLLEQEYIRDPEKTVKDLLNETIAKLGENIVIRRFVRFERGEGIETSSNE
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSB_YERE8
Sequence: MSGWRKIYYKLLNLPLKLLVKSKVIPADPVTELGLDPSRPILYVLPYNSKADLLTLRAQCQAQDLPDPLIPLEIDGVQLPSHVFIDNGPRVFRYYAPKQESVKIFHDYLDLHRNNPELDIQMLPVSVMFGRSPGREGHGTPHLRVLNGVQKFFAVLWLGRDSFVRFSTTVSLRRMASEHGTDKTIAHKLARVARMHFSRQRLAAVGPSLPARQDLFKKLLTSKAIEKAVADEARTKKISHEKAQQNAITLMEEIAADFSYEAVRLSDRVLSWTWNRLYQGINVHNAERVRQLAQDGHEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFTRGYSVEYFVEGGRSRTGRLLEPKTGTLSMTIQAMLRGGSRPITLVPIYIGYEHVMEVGTYAKELRGATKEKESLLQMLRGLRKLRNLGQGYVNFGEPIPLTTYLNTNVPQWRDAIDPIEAQRPSWLTPAVNDLAGKIMVRINNAAAANAMNLCSTALLASRQRSLTREQLLEQLDCYLQLMRNVPYAKDVTVPDKTPEELLNHALNMNKFEVEKDNIGDIIILPREQAVLMTYYRNNIQHLLILPSLIASMVMYQRRITRAELLRQISMIYPMLKAELFLHYSKEQLPQTLDTLIDELARQQLICDKGSELVLNPARIRPLQLLAAGVRETLQRYAITLSLLSANPSINRGALEKESRIMAQRLSVLHGINAPEFFDKAVFSTLVGTLREEGYISDSGDAIQEHTLEVYNMLSALMTPEVKLTIESVSMPAETNNLLPEPEAEDKEEN
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ISU1_ASHGO
Sequence: MLGFRQTATAIVRPVGTIGYARRCYHPKVIDHYTNPRNVGTLDKKLTNVGTGLVGAPACGDVMRLQIQVDDSTGVIENVKFKTFGCGSAIASSSYMTELVRGKTLADAEKIKNTEIARELSLPPVKLHCSMLAEDAIKAAIKDYRSKRKATELR
What is the function of this protein?
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.  First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISU1.  In a second step, the cluster is released from ISU1, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins.  Cluster assembly on ISU1 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH.
What are the official names of this protein?
Iron sulfur cluster assembly protein 1, mitochondrial, Iron sulfur cluster scaffold protein 1.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RPOC_YERPS
Sequence: MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERRQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKNMDLEAECEILREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERIYRAGLASLHARVKVRITEEIRNTEGESITRTSIIDTTVGRAILWMIVPQGLPYSIVNQPLGKKAISKMLNTCYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPEAKAGIIEEAETEVAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMDNLSVEDVVNRDGVVEQQVSFNSIFMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHNGIVMTPVIEGGDVKEPLRDRVLGRVTAEEVIKPGSADILVPRNTLLDEKWCDLLEENSVDSVKVRSVVSCETDFGVCANCYGRDLARGHIINKGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSLKLSNVKFVTNAAGKLVITSRNTELKLIDEFGRTKESYKVPYGAVMAKGDGAEVQGGETVANWDPHIMPVVTEVSGFIRFADMVDGQTITRQTDELTGLSSLVVLDSAERTGSGKDLRPALKIVDAKGNDVLIPGTDMPAQYFLPGKAIVQLEDGIQIGAGDTLARIPQESSGTKDITGGLPRVADLFEARRPKEPAILAEISGIISFGKETKGKRRLVISPLDGSDAYEEMIPKWRQLNVFEGEVVERGDVVSDGPESPHDILRLRGVHAVTRYITNEVQEVYRLQGVKINDKHIEVIVRQMLRKGTIVDAGSTDFLEGEQAEMSRVKIANRKLAAEGKIEATFTRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRKAQGEAPVVPQVSADEATANLAELLNAGFGNNKG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: LPDA_MYCTU
Sequence: MVTRIVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTELRRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELIDSTPGLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERILTWRQLYDLDALPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAERGVRLFKNARAASVTRTGAGVLVTMTDGRTVEGSHALMTIGSVPNTSGLGLERVGIQLGRGNYLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRLRTVAATVFTRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTGVVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEAARRLMAHDDLDCTAAQDAAEQLALVPHHLPTSN
What is the function of this protein?
May contribute to virulence by increasing resistance to reactive oxygen intermediates.  It can reduce 2,6-dimethyl-1,4-benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione.  NADPH is the physiological reductant rather than NADH.
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), NAD(P)H quinone reductase, NAD(P)H: menadione oxidoreductase, NADH-menadione reductase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Protein: RL3_VARPS
Sequence: MSLSNSLGLLGRKVGMMRLFTDDGDAVPVTVVDVSNNRVTQIKSQETDGYVALQVTFGSRKASRVTKPQAGHLAKAGVEAGEIIREFRVTADTAGQHKAGAVIAASSVFSVGQKVDVQGTSIGKGYAGTIKRHNMSSQRASHGNSRSHNVPGSIGMAQDPGRVFPGKRMTGHLGDVTKTTQNLDVFRIDEARQLLLIKGAIPGSKGGFVTVRPAIKAKPQAAEGAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: P20D1_PARBP
Sequence: MKLQYLVALLSVQAVPPVTAGYIHQYALVGSAIRQPIDQKTQREDLNKLVSDSPLLSLHRTICEIESVSNREGAVGEVLLKYLRDRGFTVEKQIVPADRGTNSTAERFNIWAYPKGCPRPKIILTSHIDTVPPHIKYSLHAPDGDFDRAKVRIMGRGTVDAKASVAAQIIAALKHLKSNKDIPLGLLFVVSEEVGGSGMVHFSNSELNTNPPFFHTLIFGEPTDLTLVDGHKGNLRVTIEAKGVAAHSGYPWLGRSAISEILPILARMDELGDIPVETGGLPSSEKYGRTTVNIGTIKGGAADNVVPETASASIAVRLAAGTPEEAEEIIRRAVYDVSGGSTNITVNFPDSMPYPPIDLDVDVEGFDISTVNYGTDIPKLEIHDEELEVKVKRYLYGPGTIFVAHGAEEGITVGDLEKAVEGYSKLIDAAVKRGWPREVVVN
What are the official names of this protein?
Probable carboxypeptidase PABG_01461, Peptidase M20 domain-containing protein PABG_01461.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
What are the subcellular locations of this protein?
Secreted.
Protein: TOP1_PASMU
Sequence: MSKSLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTVGSSNGEKAKAISTKGLSAEEKSAIKQEKDRNALVKRMGIDPYHQWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAIQQAFEKPEQLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEYWEIDVLTQTQAKQALRLAVTQFKGKKFEPKNATQAQSAVDFLQHADYVVSDLETKPTHSRAKAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALKMVRGYIQSHYGESYLPSKPVFYSSKENAQEAHEAIRPSDVNTLAEQLTGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVRAGEYELKAKGRILRFDGWTKVLPTMSKNAEDQVLPDVQLNEKLHLEHVLPEQLFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNQSFTALMNYDFTANMENILDQIANGEKNWKTELNQFFKDFSQQLSQAELDELEGGMKPNSLVPTDINCPTCGRKMAIRTASTGVFLGCSGYALPPKERCKTTMNLIPEAELLNVLDEASETKALMERKRCPKCGTAMDSYLIDPERKIHICGHNPNCDGYVLEQGSFKIKGYDGPIVECDKCGADMHLKLGRFGKYMGCTSCDNTRKILKSGEVAPPKEEPTHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELALYRDRLPEKLRYLADAPQHDPEGNDAIVRFSRKEKRQYVTSEKNGKATKWIVDYLGNQWVERKK
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: SAP15_ORYSJ
Sequence: MAQESCDLNKDEAEILKPSSSSSPSPSPTTASPSPPTAQMTEPPPPQSTPPTPPAAAAAASAAAAPQFSAKNCEGILIEVSKKRKLAEATATDANAVVVAAVAEPLSPVLFVNRCNVCRKRVGLTGFRCRCGELFCPRHRHSETHECSFDYKTAGREEIARANPVIRAAKIIKI
What is the function of this protein?
May be involved in environmental stress response.
What are the official names of this protein?
Zinc finger AN1 domain-containing stress-associated protein 15, OsSAP15.
Protein: KDSA_GEOSL
Sequence: MTREITIGSVKIGGDRPLVLIAGPCVIENEAATLRCAERLMTICNGVSVSLVFKASYDKANRTSVTSFRGPGMQEGLRILQKVKDSLGIPVISDIHSIEQVKPAAEVLDIIQVPAFLCRQTDLVVEVGRTNRVVNVKKGQFMAPWDMENVVGKILSTGNERIILTERGVTFGYNNLVSDMRSLPIMRRIGFPVVFDATHSVQLPGGQGGSSGGQREFVEYLSRAAVATGIDGIFMEVHEDPEKALCDGPNSVKLDDLPALLKKLKAIDAIVK
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y715_PSYIN
Sequence: MYSNLKSIGVVNYDNIDKYTLRQEGDTDILKIYFRKASRQFLAKSLKFKFPRQRKKISQDHGSSGFRNVSEIGSTLRYVLKELDSLTEHVKEEKELKVQVLEDLKHLESVVASKIKEIERKLEQM
What are the official names of this protein?
UPF0325 protein Ping_0715.
What is the protein family that this protein belongs to?
Belongs to the UPF0325 family.
Protein: PG115_VACCC
Sequence: MDIFIVKDNKYPKVDNDDNEVFILLGNHNDFIRLKLTKLKEHVFFSEYIVTPDTYGSLCVELNGSSFQHGGRYIEVEEFIDAGRQVRWCSTSNHISEDIPEDIHTDKFVIYDIYTFDAFKNKRLVFVQVPPSLGDDSHLTNPLLSPYYRNSVARQMVNDMIFNQDSFLKYLLEHLIRSHYRVSKHITIVRYKDTEELNLTRICYNRDKFKAFVFAWFNGVSENEKVLDTYKKVSNLI
What is the function of this protein?
Late protein which is part of a large complex required for early virion morphogenesis.  This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions.
What are the official names of this protein?
Core protein OPG115, 27 kDa virion core protein.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG115 family.
Protein: CTAA_LISMC
Sequence: MKKFLKVWSVLTIICMTVVVFGGALVTKTGSADGCGNSWPLCNGQLVRLTDVTPEKLIEFMHRMTTGISSIFVIVLAICAWIYMKNRRETKPLAIIAVLFLIIQALMGMAAVVWGQNPYIMALHFGISIICYASIVLLALMIFEVDRKFDARNLVMGTKLRINIYALTIYTYLAVYTGALVRHEKASMAVPVWPFENGHFIMPTSVQDYVQYFHRLAAFILIVWLLYVTWLVFRDYRRYRVLTFSMVLSLVFIALQAVTGALSVYTGVNLYIALAHSLIITMLFALLCYLCLLASRSKSNRLRIK
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARFO_ARATH
Sequence: METGNVVNAQPELSGIIDRSKSYMYEQLWKLCAGPLCDIPKLGEKVYYFPQGNIELVEASTREELNELQPICDLPSKLQCRVIAIHLKVENNSDETYAKITLMPDTTQVVIPTQNENQFRPLVNSFTKVLTASDISANGVFSVPKKHAIECLPPLDMSQPLPAQELLAIDLHGNQWSFRHSYRGTPQRHLLTTGWNEFTTSKKLVKGDVIVFVRGETGELRVGIRRARHQQGNIPSSIVSIDCMRHGVIASAKHAFDNQCMFIVVYKPRSSQFIVSYDKFLDAVNNKFNVGSRFTMRFEGDDLSERRYFGTIIGVSNFSPHWKCSDWRSLEVQWDEFASFLRPNKVSPWEIEHLMPALNVPRSSFLKNKRLREVNEFGSSSSHLLPPILTQGQEIGQLSVASPMNISLLYRETTEDAMNPSRLLMSYPVQPMPKRNYNNQMVTQIEENITTKAGTNFRLFGVSLATPPVIKDPIEQIGSDISKLTEGKKFGQSQTLRSPTKIQSKQFSSTRTCTKVQMQGVTIGRAVDLSVLNGYDQLILELEKLFDLKGQLQTRNQWKIIFTGSDEDEMLVGDDPWPEFCNMVKRIYIQKRR
What is the function of this protein?
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).  Could act as transcriptional activator or repressor.  Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.
What are the official names of this protein?
Putative auxin response factor 15.
What is the protein family that this protein belongs to?
Belongs to the ARF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUTC_ENTCC
Sequence: MPKSVIIPPGTSTPIAPFVPGTLADGVVYVSGTLPFDKDNNVVFINDPKAQTRHVLETIKTVIETAGGTMEDVTFNSIFITDWKNYAAINEIYAEFFPGDKPARFCIQCGLVKPDALVEIATVAHIGK
What is the function of this protein?
Involved in pyrimidine catabolism.  Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously.  RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.
What are the official names of this protein?
3-aminoacrylate deaminase RutC, 3-AA deaminase.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: PHNN_JANMA
Sequence: MHGSTGFVQGTRPAGDQADPLPVVRVSSESMTRYALYFTPVDDSPWAQAGSSWLGRHPASPEPVQQVNIPGIPRILLSSLTADARRYGFHATLKAPFRLFEGFNEEHLLQMARAFCAAQKAIVLDEVRVRPLMDFLALQVNGPLDEIGGLAMRCVTYFDLLRAPLTEPELAKRRRAGLNARQSALLQRWGYPYTEEFYRFHMTLTDALMHADADVIFTIRKAAEQHFAAAVAAVPLAIDALTIAREEYPGAPFVEWQRIPFSGQGERASLPHSGRIFFCVGPSGVGKDSLLNWVREHSAGDEKLVFAQRTITRATQANEAHEAVDTASFWRLAAGGQFAMVWQANDLCYGIRRGIEADLKAGRDVVINGSRAYVPQLLQAFPDAIVIWIDASENLLRERLEARQREQGPALLKRLKRAKEFAPSEQAQVIRLDNSGALEAGGQKLLDILRQAK
What is the function of this protein?
Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
What are the official names of this protein?
Ribose 1,5-bisphosphate phosphokinase PhnN, Ribose 1,5-bisphosphokinase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ribose 1,5-bisphosphokinase family.
Protein: TUSD_SHIDS
Sequence: MRFAIVVTGPAYGTQQASSAFQFAQALIAEGHKLSSVFFYREGVYNANQLTSPASDEFDLVRGWQQLNAQHGVALNICVAAALRRGVVDETEAGRLGLASSNLQQGFTLSGLGALAEASLTCDRVVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.