PharMolix/UniProtQA huggingface dataset:
Protein: DTD2_CHICK
Sequence: MAAARPVLARALLQQCLFARLQVKPPEHGAEAEWEEIQRGLVIYICFFKGADEDLVPKIVNVLLNVKLSEDENGEYVSVLDLPGNVLIIPQATLGGKLKGRKMQYHTNIEKEKGMELYSQFVSLCEKELAANPKCMEAGVLVKHGTYGNRQVLKLDTNGPYTHLVEF
What is the function of this protein?
Deacylates mischarged D-aminoacyl-tRNAs (By similarity).  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity).  Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity).  Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity).  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.  In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4. U69) by alanine-tRNA ligase AARS (PubMed:29410408).  Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408).  Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity).
What are the official names of this protein?
D-aminoacyl-tRNA deacylase 2, Animalia-specific tRNA deacylase, ATD, D-tyrosyl-tRNA(Tyr) deacylase 2, L-alanyl-tRNA deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU6M_URILO
Sequence: MTYFVLFLGLCFVLGGLAVASNPSPYYGVVGLVLASVAGCAWLLSLGVSFVSLVLFMVYLGGMLVVFVYSVSLAADPFPEAWGDWRVVGYGMGFVAVLVMGMVVGGFECWDLGVVTVDSVGMFSVRLDFGGVAMFYSCGVGMFLVAGWGLLLTLFVVLELVRGLTRGAIRAV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: STAU2_RAT
Sequence: MANPKEKTPMCLVNELARFHSIQPQYKLLNESGPAHSKMFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKPFPNYRANYNFRGMYNQRYHCPMPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPEKSPQNGESGKEMDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLPPLPVIEKPKLFFKKRPKTIIKAGPEYGQGMNPISRLAQIQQARKEKEPDYVLLSERGMPRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLGYKASTSLQDQLDKTGENKGWSGPKPGFPEPANNTPKGILHLSPDVYQEMEASRHRVTSGTTLGYLSPKDMNQPSSSFFSVESPSPTSSAPAARELLMNGTSPAAEAIGLKGSSPTPPCSSVQPSKQLEYLARIQGFQAALSALKQFSEQGLESIDGVVNVENGSLEKQAKHLREKADNNQANPGSITQDCKKSKSVI
What is the function of this protein?
RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite.  As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body.
What are the official names of this protein?
Double-stranded RNA-binding protein Staufen homolog 2, r-staufen protein.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and may require the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1- independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted.
Protein: COMTA_DANRE
Sequence: MLWVVLAVVVVLASVLVLLRQSSGLLALLWHDVVHQRLLNFFTGLSRPQRILKAVQKNATKGNPESVIAAIDHYCRHSEWAMNVGDEKGLILDSVVTEVNPSTALELGTYCGYSTVRIARLLSPGTKLITLEFNPDYAAIARQIIAYAGLQDKVILVEGPSGDLIPKMKQQHGIKSFDFVFLDHWKDRYVPDTKLLEECGLLRKGSVLLADNVICPGTPEYLKYVRNDPRYESRYFKSNLEYTKVEDGLEKSVFLG
What is the function of this protein?
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.  Shows highest activity towards catecholestrogens and dobutamine.  Also has lower activity towards L-DOPA, dopamine and epinephrine.  Active towards the xenobiotic compounds methyl-DOPA, carbidopa, isoproterenol, and apomorphine.
What are the official names of this protein?
Catechol O-methyltransferase A.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLGA_LACP3
Sequence: MLKVLFTAAESAPFYKTGGLGDVTYALPKAIKKQGVDIRVAIPFYEKKFPAKYLPKVKDLTHFTLEMDGRPVYVGLKTIKLGDVTYYLIDNRQYFDRDGLYGYWDDGGRFGYFQMAVIEMLQVIEWIPDVIHANDWHTAFIPVLLKEKYGWIKPYQQIKTQLTIHNLQFQGWFPPSTLATVFGIGREGFNDDGFGQDGSINWLKGGINYADLVSTVSPSYAKEIQTPAFGEHLDGTLRKQSGKLVGILNGIDSEVYNPATDQNLAYNYDAKNLAGKAKDKKALQDEMHLPKRTDPLFAMVSRLTRQKGADLLVDALENFLVQNNVQVVVLGTGDQDLEEDLSSLQDRFPGQLAVRIDFDEGLAQRIYAGADYFMMPSAFEPSGLAQMMAMRYGTLPIVHETGGLRDSVLAYNAETGAGDGFSFWDYNAGVLTNILRMAKSVYADQPKVYAKLQQHAMVKDFDWHHSAAEYLKGYQRILGKA
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: UD110_HUMAN
Sequence: MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
What is the function of this protein?
Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
What are the official names of this protein?
UDP-glucuronosyltransferase 1A10, UGT1A10, UDP-glucuronosyltransferase 1-10, UDPGT 1-10, UGT1*10, UGT1-10, UGT1.10, UDP-glucuronosyltransferase 1-J, UGT-1J, UGT1J.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: SRY_APOFL
Sequence: PMNAFMVWSCGERRKLAQQNPSMQNTQISKQLEYGWKSLTEAEKRTLFQEAQRLKTL
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: FABA_BRUC2
Sequence: MAEQKSSYGYEELLACGRGEMFGPGNAQLPLPPMLMIHRITEISETGGAFDKGYIRAEYDVRPDDWYFPCHFQGNPIMPGCLGLDGMWQLTGFFLGWLGEPGRGMALSTGEVKFKGMVRPHTKLLEYGIDFKRVMRGRLVLGTADGWLKADGELIYQATDLRVGLSKEGSAQ
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFD1_CANAL
Sequence: MSSELLQEVPKSIEHVKHIILILSGKGGVGKSSVTTQVALTLVNKGFNVGVLDIDLTGPSLPRMFGVENKQVHQSTQGWVPVSVYNNNNNQGTDSKRGNLSLMSLGFLLGDRGNSVVWRGPKKTAMIKQFLKDVVWGSTETPLDYLLIDTPPGTSDEHIAIAEELRWANPIDGAIIVTTPQQVATADVRKEINFCKKVNFQILGIVENMSGFICPHCSECTNIFSSGGGKALSEQLNLTYLGNVPIDPQFVELVELQNEQENKKLIELYDDCELKPILNGIVDKILDKNLPSRI
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.  Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor CFD1, Cytosolic Fe-S cluster-deficient protein 1.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYNC3_ARATH
Sequence: MGDEIVPPANQLAADNLENDGSTVQKAQFSDRVLIRSILGGGAKLAGQKVRIGGWVKTGRQQGKGTFAFLEVNDGSCPANLQVMVDSSLYDLSRLVATGTCVTVDGVLKIPPEGKGLKQSIELSVETVIAVGTVDPTTYPLPKTKLTPEFLRDVLHLRSRTNLISAVARIRNALAFATHSFFQEHSFLYIHTPIITTSDCEGAGEMFQVTTLINHTERVEQDLIDNPPPTEADVEAARLIVKERGEAVAQLKVAKASKEEITASVAQLSVAKASLAHVEERLRLKPGLPKNDGKIDYSNDFFGRQAFLTVSGQLQVETYACALSSVYTFGPTFRAENSHTSRHLAEFWMVEPEIAFADIHDDMNCAEAYVKYMCKWLMDKCGDDMELMDKNVDEGCTKRLNMVAKASFKRVTYTEAIERLEKAVAQGKVVFDNKVEWGIDLASEHERYLTEVEFDQKPIIVYNYPKGIKAFYMRLNDDEKTVAAMDVLVPKVGELIGGSQREERYDVIKQRIEEMGLPMEPYEWYLDLRRYGTVKHCGFGLGFERMIQFATGIDNIRDVIPFPRYPGKADL
What are the official names of this protein?
Asparagine--tRNA ligase, cytoplasmic 3, Asparaginyl-tRNA synthetase 3, AsnRS 3.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: APAH1_PSEAE
Sequence: MLSVYSDDHRLHFGQSELVDGKLQPCFEMPSRADTVLARVKSQNLGEVIAPKDFGREPLLRLHDAAYLDFLQGAWARWTAEGHSGDLVSTTFPGRRLRRDGPIPTALMGELGYYSFDTEAPITAGTWQAIYSSAQVALTAQEHMRQGARSAFALCRPPGHHAGGDFMGGYCFLNNAAIATQAFLDQGARRVAILDVDYHHGNGTQDIFYRRDDVLFASIHGDPRVEYPYFLGYADERGEGAGEGCNHNYPLAHGSGWDLWSAALDDACVRIAGYAPDALVISLGVDTYKEDPISQFRLDSPDYLRMGERIARLGLPTLFIMEGGYAVEAIGINAVNVLQGYEGAAR
What is the function of this protein?
Catalyzes the deacetylation of acetylated polyamines such as N-acetylputrescine, N-acetylcadaverine, N(1)-acetylspermine and N(1)-acetylspermidine.  Plays an important role in the metabolism of acetylated polyamines in P. aeruginosa.  Is involved in the degradation pathways of N-acetylputrescine and N-acetylcadaverine, that allow P. aeruginosa to utilize these acetylpolyamines as a carbon source under glucose starvation.  In vitro, can also hydrolyze artificial trifluoroacetylated and acetylated lysine-derivatives.
What are the official names of this protein?
Acetylpolyamine amidohydrolase 1, APAH 1, Acetylcadaverine deacetylase, Acetylpolyamine deacetylase, Acetylputrescine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family.
Protein: ARCA_PSEAE
Sequence: MSTEKTKLGVHSEAGKLRKVMVCSPGLAHQRLTPSNCDELLFDDVIWVNQAKRDHFDFVTKMRERGIDVLEMHNLLTETIQNPEALKWILDRKITADSVGLGLTSELRSWLESLEPRKLAEYLIGGVAADDLPASEGANILKMYREYLGHSSFLLPPLPNTQFTRDTTCWIYGGVTLNPMYWPARRQETLLTTAIYKFHPEFANAEFEIWYGDPDKDHGSSTLEGGDVMPIGNGVVLIGMGERSSRQAIGQVAQSLFAKGAAERVIVAGLPKSRAAMHLDTVFSFCDRDLVTVFPEVVKEIVPFSLRPDPSSPYGMNIRREEKTFLEVVAESLGLKKLRVVETGGNSFAAEREQWDDGNNVVCLEPGVVVGYDRNTYTNTLLRKAGVEVITISASELGRGRGGGHCMTCPIVRDPIDY
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_DESAP
Sequence: MAKHLFTSESVTEGHPDKVADQISDAILDSILSKDPLARVACETLVTTGLVLISGEITCKCYVDIPNIVRETVRDIGYTRAKYGFDCDTCAVLTSIDEQSPDIAMGVDEALEAREGLDDLFSRVGAGDQGIMVGYATDETPTLMPMPIYLAHRLARRLASVRKNGTLPYLRPDGKTQVTVQYDNGRPVKVDTVVISAQHHPAVDLGTIRADLIEKVVEPIIPVGLITNSTRYLINPTGRFVIGGPQADTGLTGRKIVVDTYGGMARHGGGAFSGKDPTKVDRSASYAARYVAKNIVAAGLASRCEVHVAYAIGVAKPVALRVDTFGTGLINEERLEKLVLEHFDLRPAAIIHHLDLRRPIYRQVAAYGHFGRGDLNLPWERIDKAEELRAAGTGG
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAF2_RAT
Sequence: MLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALSDAKRELRFLLVYLHGDDHQDSDEFCRNALCAPEVISLINSRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPDSVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCVPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE
What is the function of this protein?
Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.  By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.  Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.
What are the official names of this protein?
FAS-associated factor 2, UBX domain-containing protein 8.
What are the subcellular locations of this protein?
Cytoplasm. Lipid droplet. Endoplasmic reticulum.
Protein: BLK_MOUSE
Sequence: MGLLSSKRQVSEKGKGWSPVKIRTQDKAPPPLPPLVVFNHLAPPSPNQDPDEEERFVVALFDYAAVNDRDLQVLKGEKLQVLRSTGDWWLARSLVTGREGYVPSNFVAPVETLEVEKWFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDITTQGEVVKHYKIRSLDNGGYYISPRITFPTLQALVQHYSKKGDGLCQKLTLPCVNLAPKNLWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTREPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVLEDFYTATEGQYELQP
What is the function of this protein?
Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling.  B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (PubMed:2404338, PubMed:7690139, PubMed:7608542, PubMed:9636152, PubMed:14662906, PubMed:12563261).  Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:2404338, PubMed:7690139, PubMed:7608542, PubMed:14662906, PubMed:12563261).  Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (PubMed:2404338, PubMed:7690139, PubMed:7608542, PubMed:14662906, PubMed:12563261).  Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (PubMed:7592958, PubMed:9177269).  Phosphorylates also the immunoglobulin G receptor FCGR2 (By similarity).  With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (PubMed:14662906, PubMed:12563261).  Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (PubMed:7565679).  In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (By similarity).  Phosphorylates CGAS, promoting retention of CGAS in the cytosol (By similarity).
What are the official names of this protein?
Tyrosine-protein kinase Blk, B lymphocyte kinase, p55-Blk.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Present and active in lipid rafts (By similarity). Membrane location is required for the phosphorylation of CD79A and CD79B.
Protein: RL15_BIFLO
Sequence: MADNEILQMHDLKPAPGAKKDRTRVGRGEGSKGKTSGRGAKGQTKRNHVRPGFEGGQLPLYMRLPKLRGFKNPFKVEFQVINIARLVELFPEGGEVAVADLIAKGAVRDNAPVKVLGDGETTVAFTLKGVKASASAKSKIEAAGGSVSED
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RASLC_DANRE
Sequence: MSLMFGKARTCNIVTVPEHEPSEVNIVILGAMGSGKSALTVKFLTKRFISEYDPNLEDTYSSEEVVDQQPVLVKVMDTADQEGPVNGERYLGWANAFIIVYSIDNRSSFEVCQQYLETVSLYSKGLQPEAPVILLGNKVDMERYRQVSKADGAALALRFGCLFFEVSACLDFLSVQHIFHEAVREVRRETERSIRPLFISEDKSAISLSSAPPLTACYKELPTPATAKLVTVKSSRAQSKRRAPTLTLLKGFKIF
What are the official names of this protein?
Ras-like protein family member 12, RAS-like protein Ris.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
Protein: BR2C_RANTE
Sequence: GLWETIKNFGKKFTLNILHKLKCKIGGGC
What is the function of this protein?
Antibacterial activity against representative Gram-negative and Gram-positive bacteria.
What are the official names of this protein?
Brevinin-2Tc.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: TAF1A_MOUSE
Sequence: MMSDFGEELTKLAVAEDNPETSVLSKTGMHFPWLHKHVEAVVTGGKKRKDFAQTTSACLSFIQEALLKHQWQQAAEYMHSYLQTLEDSDTDKRQAAPEIIWKLGSEILFYHPKSNVETFNSFADRMKNIGVLNYLKISLQHALYLLHHGMLDDANRNLSKAETWRYGEKSSSQEVLINLVQAYKGLLQYYTWTRKKMELSKLDEDDYAYAAKTRTMLSQSCKTSTNICALVKTPGVWDPFVKSYVEMLEFYGDQDGAREMLTNYAYDEKFPSNPNAHVYLYEFLKREKAPRAKLISVLKILHEIVPSHTLMLEFHTLLRKSDTEEHQKLGLSVLFEVLDFAGCNKNITAWKYLAKYLKQILVGSHHEWVEEEWKSRRNWWPAFHFSFFWAKSDWKADTDLACEKAFVAGVLLGKGCKYFRYILKQDHETLKKKIKRMKKSVKKYTIVNPGVHT
What is the function of this protein?
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription.  The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter.  SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.  Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity).
What are the official names of this protein?
TATA box-binding protein-associated factor RNA polymerase I subunit A, RNA polymerase I-specific TBP-associated factor 48 kDa, TAFI48, TATA box-binding protein-associated factor 1A, TBP-associated factor 1A, Transcription initiation factor SL1/TIF-IB subunit A.
What are the subcellular locations of this protein?
Nucleus.
Protein: ROQN_PENRW
Sequence: MTRATNFTELYAGKGILDTYMVAEKITRYYTQDLIQLSGLSESSLTPLVILDLACGTGVVSDALHDMLNFQPKGNWELTCGDISTELTGHVKQKILERGWENSIAKVVDAQNTELPTGHYTHVFAALAFTSFPDTYAAMKEVMRILQPGGTLTISTWQRTEWLAVVEAAVAIIPADLPFPTTKEFMSCMNPGWDSEDYVHSRFEEAGFHSVQVTTISKQFETSVEDLYKIAQPVIPIIVSKWWNQEQRDKYENDILPALQRHLNETYGENGLVPQEWTAVFATGQKGS
What is the function of this protein?
Glandicoline B O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the mycotoxin meleagrin (PubMed:22118684, PubMed:23776469).  The first stage is catalyzed by the dipeptide synthase roqA which condenses histidine and tryptophan to produce histidyltryptophanyldiketopiperazine (HTD) (PubMed:22118684, PubMed:23776469).  HTD is then converted to roquefortine C through two possible pathways (PubMed:23776469).  In the first pathway, prenyltransferase roqD transforms HTD to the intermediate roquefortine D, which is in turn converted to roquefortine C by the cytochrome P450 monooxygenase roqR (PubMed:23776469).  In the second pathway, HTD is first converted to the intermediate dehydrohistidyltryptophanyldi-ketopiperazine (DHTD) by roqR which is then prenylated by roqD to form roquefortine C (PubMed:23776469).  Roquefortine C can be further transformed to meleagrin via three more reactions including oxydation to glandicolin A by roqM, which is further reduced to glandicoline B by roqO (PubMed:23776469).  Finally, glandicoline B is converted to meleagrin by the glandicoline B O-methyltransferase roqN (PubMed:22118684, PubMed:23776469).  More studies identified further branching and additional metabolites produced by the roquefortine/meleagrin cluster, including roquefortine F, roquefortine L, roquefortine M, roquefortine N and neoxaline (PubMed:24225953).
What are the official names of this protein?
Glandicoline B O-methyltransferase roqN, Roquefortine/meleagrin synthesis protein N.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily.
Protein: CC070_MOUSE
Sequence: MSAATAPERGWKSEKVDEAQALARSCAARRPDFQPCDGLSICATHSHGKCFKLHWCCHLGWCHCKYVYQPMTPVEQLPSTEIPAKPREPTNTIQISVSLTEHFLKFASVFQPPLPPDSPRYCMISDLFIDNYQVKCINGKMCYVQKQQAPHSQKMSPEEVSAHDALISKESDTPKLGHCSSPSGSEDSGINAIGAHYVESCDEDTEEGAELSSEEDYSPESSWEPDECTLLSPSQSDLEVIETMETTV
What is the function of this protein?
May play a role in neuronal and neurobehavioral development.
What are the official names of this protein?
UPF0524 protein C3orf70 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0524 family.