PharMolix/UniProtQA huggingface dataset:
Protein: RPO7_SULAC
Sequence: MFKLVRAKGIVRIPPEYFGQSVDEIAIKILRQEYQEKLIKDIGVVLGIVNAKASEEGFIIFGDGATYHEVEFDMLVYTPIIHEVIEGEVSQVDNYGVYVNMGPVDGLVHISQITDDNLKFDSNRGILIGEKSKKSIQKGDRVRAMIISASMSSGRLPRIALTMKQPYLGKIEWINQEIAKASK
What is the function of this protein?
Reconstitution experiments show this subunit is required for basic activity.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo7, DNA-directed RNA polymerase subunit E.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INSL3_PANTR
Sequence: MDPRLPAWALVLLGPALVFALGPAPTPEMREKLCGHHFVRALVRVCGGPRWSTEARRPAAGGDREWLQWLERRHLLHGLVANSNLTLGPGLQPLPQTSHHHRHHRAAATNPARYCCLSGCTQQDLLTLCPY
What is the function of this protein?
Seems to play a role in testicular function.  May be a trophic hormone with a role in testicular descent in fetal life.  Is a ligand for LGR8 receptor (By similarity).
What are the official names of this protein?
Insulin-like 3, Leydig insulin-like peptide, Ley-I-L, Relaxin-like factor.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GRRA_EMENI
Sequence: MARSRQPTRFSSEAPSESSSSTSPERAADDDTDFFTLQANDSQSSIGAGNPRDSHIQNDPETVLPPIAYLPPEILISIFSKLSSPRDLLSCLLVCRIWALNCVGLLWHRPSCNNWDNLKKIAAAVGEEDSFFLYSSLIKRLNLSALTEDVSDGTVVPFSQCNRIERLTLTNCRKLTDIGVSDLVVGSRHLQALDVSELRSLTDHTLFKVAENCNRLQGLNITGCVKVTDDSLIAVSQNCRLLKRLKLNGVSQVTDKAILSFAQNCPSILEIDLQECKLVTNQSVTALMTTLQNLRELRLAHCTEIDDSAFLDLPRHIQMTSLRILDLTACENIRDEAVERIVSSAPRLRNLVLAKCKFITDRAVWAICKLGKNLHYVHLGHCSNINDSAVIQLVKSCNRIRYIDLACCSRLTDRSVQQLATLPKLRRIGLVKCQLITDASILALARPAQDHSVPCSSLERVHLSYCVNLTMVGIHALLNSCPRLTHLSLTGVAAFLREELTVFCREAPPEFTRQQREVFCVFSGEGVNRLRNHLNREAAPQRDANEATMYDDEEELDEDEGQVTGLMHAAAINDDDYINITPPHA
What is the function of this protein?
Involved in meiosis and required for ascospore formation.  Involved in substrate recognition in ubiquitin-dependent degradation.
What are the official names of this protein?
SCF E3 ubiquitin ligase complex F-box protein grrA, F-box and leucine-rich repeat protein grrA, F-box/LRR-repeat protein grrA, SCF substrate adapter protein grrA.
What are the subcellular locations of this protein?
Cytoplasm. Note=In the cytoplasm of ascogenous cells. Within these cells, defined areas that resembled immature ascospores were excluded from the staining.
Protein: Y1296_SHEB2
Sequence: MKPQWQQYINIIKQVVKPALGCTEPIAAAYAAAVARALLGVEPDSIAVQVSDNLYKNSMGVFVPGTGKIGLAIAAAAGAIAGNPDAGLEVLAVITPEQVARAQALIDAGKVTVERTETAEFIYCCVIAKKGDREALVKICGGHTLIAEKRLNGESVFSVDSTQAKATGSICEGVDITIESIYRFAQEVPFEEIKFILEASELNGKLSDEGMANPYGLEVGRTMKSGIAAGIIGEDLLNKIVMLTAAASDARMGGANLPAMSNLGSGNQGIAATIPVVLTAQCYKVSEEQLARALIMSHLGAIYIKSHYPPLSAFCGNTVTSAAASMAMVYLAGGSFEQSCFAIQNVISDSSGMVCDGAKASCAMKVSTSSSAAVRSFLMALSSHNVSGQGIIATDVEKTIKNIGKMILNGMSSTDVTIIDIMSA
What are the official names of this protein?
UPF0597 protein Sbal223_1296.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: WASC2_RAT
Sequence: MNRTSPDSEQPPASEPVWERPWSVEEIRRSSQNWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIQETKATHCRLHNVFNDFLMLSNTQFIENRVYDEEVEDQALKTEAEKAEQEKTREQKEIDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEEDANERVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDSEDEKEEEESDDFASHSDNEQNQHITQMSDEEEDDDADLFADSEKEGDDIEDIEESAKSKRPTSFADELAARIKGDVSNQRKEGHTDGKPQRTVKEKKERRTPADDEEDILFPPPTLTDEDFSPFGSRGGLFSDRQGLFDDDDESDLFKEAPRGQPAQGPVSEESPPSPKPGKKIPAGAVSVFLGYTDVSGSTSAPSLKEFQKHEQSTPGKSPHLPAPTGLFDDDDNDSDEDDNFFMPSSSKPSKTDKVKPTTIIFDDDEGDLFKEKTTALPAASVSQTDENKARTDKTITLPSSKNPKLVSETKTQKGLFSDEEDSEDLFSSQSSSKTKSASVLSSQPPASVSLFGDEDEEDNLFGSAAAKKQTSSLPPQSQEKAKPSEQPPKKASALFSSDEEDQWSVADSQTKLASERKSKGERWDAGTNQGQEAKAVKKTNLFEEEDDDGVDLFAIAKDSQKKTQRTSLLFEDDTDSGSSLFSLPPTSVPPAATKKESIPKVPLLFSDEEDSEVPSGVKPVDLKAENAAASPEVGSADVANVAQKEGLLPTSDQEAGGPSDIFSSSSPLDKGAKGRTKTVLSLFDEDEDKVEDDSNTCAPQGGLEKGVKTDRRPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKTRLSMPSGGSLFGDDDDDDLFSTAKTQPAQPVVPEKKGTLRKDHKPPELTEGSKEKSTWKAETAQDSSGLTPFKSREPSSRIGKIQANLAINPATLLPSVAPQIPGAKPASCELAFPSSEPARSHIREAVPTLPGSEEAGVSFDLPAQADTLHSANKGRVKVRGKRRPQTRAARRLAAQESSEAEDVTIDRGPVTQLSSSPVLPNGHQPLLQPRMASGETSSEKAMAVPWEGGPVLSAVDRSFFVKSLPQTGNEAHLFDSGDIFPKSTGSQSMEGASVKAGETPAHSSAGRKEKSLVFPDLSEASGVDDLFQSAKPRPTKKRNPFPLLEDEEDLFADQKGKKNQWKSDSHQDVVSKTQDIFEDDIFATEAIKKPFPKKREKERTLEPNLFDDNIDIFADLTVKPKEKPKKKVTAKSMFDDDTDDIFSSGLQAKASKPKSQSAEAVSELRSENKVSNIFDDPLNAFGSQ
What is the function of this protein?
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.  Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC.  Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission.  Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2).  Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1.  Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35.  Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L.
What are the official names of this protein?
WASH complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the FAM21 family.
What are the subcellular locations of this protein?
Early endosome membrane. Cell membrane.
Protein: RECO_STRA5
Sequence: MRVSQTYGLVLYNRNYREDDKLVKIFTETEGKRMFFVKHASKSKFNAVLQPLTIAHFILKINDNGLSYIDDYKEVLAFQETNSDLFKLSYASYITSLADVAISDNVADAQLFIFLKKTLELIEDGLDYEILTNIFEVQLLERFGVALNFHDCVFCHRVGLPFDFSHKYSGLLCPNHYYKDERRNHLDPNMLYLINRFQSIQFDDLQTISVKPEMKLKIRQFLDMIYDEYVGIHLKSKKFIDDLSSWGSIMKSD
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: UPP_METPP
Sequence: MPVLEVLHPLVRHKVGLLRAADISTKKFREITAEIARLLAYEATADFPLEQVTVECWSGPTAVDQIKGKKVTIVPILRAGLGMMDGVLDMIPNAKISVVGLSRNHDTLQPEHYFENLVGSLEERTALIIDPMLATAGSMIATVDLLKRKGCRDIRALVLVAAPEGVKALSAAHPEVRCWTAAIDSHLNEVGYIIPGLGDAGDKIFGTKG
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: HPS_MYCGS
Sequence: MKLQVAIDLLSTEAALELAGKVAEYVDIIELGTPLIEAEGLSVITAVKKAHPDKIVFADMKTMDAGELEADIAFKAGADLVTVLGSADDSTIAGAVKAAQAHNKGVVVDLIGIEDKATRAQEVRALGAKFVEMHAGLDEQAKPGFDLNGLLAAGEKARVPFSVAGGVKVATIPAVQKAGAEVAVAGGAIYGAADPAAAAKELRAAIA
What is the function of this protein?
Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate.
What are the official names of this protein?
3-hexulose-6-phosphate synthase, HPS, D-arabino-3-hexulose-6-phosphate formaldehyde lyase.
What is the protein family that this protein belongs to?
Belongs to the HPS/KGPDC family. HPS subfamily.
Protein: HEL_HAEIN
Sequence: MKTTLKMTALAALSAFVLAGCGSHQMKSEGHANMQLQQQAVLGLNWMQDSGEYKALAYQAYNAAKVAFDHAKVAKGKKKAVVADLDETMLDNSPYAGWQVQNNKPFDGKDWTRWVDARQSRAVPGAVEFNNYVNSHNGKVFYVTNRKDSTEKSGTIDDMKRLGFNGVEESAFYLKKDKSAKAARFAEIEKQGYEIVLYVGDNLDDFGNTVYGKLNADRRAFVDQNQGKFGKTFIMLPNANYGGWEGGLAEGYFKKDTQGQIKARLDAVQAWDGK
What are the official names of this protein?
Lipoprotein E, Outer membrane protein P4, OMP P4.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: E13K_TOBAC
Sequence: MCSIQIIGAQSIGVCYGKAANNLPSDQDVINLYNANGIRKLRIYYPDKNIFKALNGSNIEIILGVPNQDLEALANSSIANGWVQDNIRSHFPYVKFKYISIGNKVSPTNNDQYSEFLLQAMKNVYNALAAAGLQDMIKVSTVTYSGVLANTYPPERSIFREEFKSFINPIIQFLARNNLPLLANVYPYFVHVSNTADVSLSYALFTQQGTNSAGYQNLFDAILDSMYFAVEKAGGPNVEIIVSESGWPSEGSSAATIENAQTYYRNLINHVKSGAGTPKKPGKTIETYLFAMFDENDKIGEITEKHFGLFSPDQRAKYQLNFNYLPIYILR
What is the function of this protein?
Is thought to be an important plant defense-related product against fungal pathogens.
What are the official names of this protein?
Glucan endo-1,3-beta-glucosidase, acidic isoform GL161, (1->3)-beta-glucan endohydrolase, (1->3)-beta-glucanase, Beta-1,3-endoglucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: MEP6_ARTOC
Sequence: MRLSLFLSGLAAAGSIVSAERTCGAVPPRGYEKEFSEAFAALGPEATSDLTAGITIDTYLHVLTSGTTGNIPDSQLQAQINAMNQHYGPSGVQFRLVKATRTNNANWASGRDEAGMKSALHMGTYSSLNIYFIPNLSSGLLGICYFPRANPSQTTITMDGCMVRSGTVPGGETTNYNQGKTATHEVGHFLGLYHVFSENGSCVDADMVADTPPQSKKTSGCPNSQDSCPGGGVDSIHNYMDYSYDVCMNQFTRGQASRIAQAWQAFRAGH
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Plays a pivotal role as a pathogenicity determinant during infections and contributes to the ability of the pathogen to persist within the mammalian host (By similarity).
What are the official names of this protein?
Extracellular metalloprotease MCYG_04966.
What is the protein family that this protein belongs to?
Belongs to the peptidase M43B family.
What are the subcellular locations of this protein?
Secreted.
Protein: TBB1_SOLTU
Sequence: MREILHIQGGQCGNQIGSKFWEVICDEHGVDPTGRYKGTAAESDLQLERINVYFNEASGGRYVPRAVLMDLEPGTMDSIRSGPYGQIFRPDNLVFGQSGAGNNWAKGHYTEGAELIDAVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKVREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPLPRLHFFMVGFAPLTSRGSQQYISLTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPTGLKMASTFVGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDPVAEYQQYQDATADDEEEYDDEAADDHQYES
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-1 chain, Beta-1-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ATPE_RHILW
Sequence: MADNFNFELVSPERLLLSEMVTEVVIPATEGEMTVMAHHAPTMTTIKPGVVSVRSASGKKQDYVVFGGFADILPTGCTLLAESAVPVEELHKDELTRRIEAARKELEDTELHEHKSKLEHFIMELTHLRGVVQQD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SMG_ECOBW
Sequence: MFDVLMYLFETYIHTEAELRVDQDKLEQDLTDAGFEREDIYNALLWLEKLADYQEGLAEPMQLASDPLSMRIYTPEECERLDASCRGFLLFLEQIQVLNLETREMVIERVLALDNAEFELDDLKWVILMVLFNIPGCENAYQQMEELLFEVNEGMLH
What are the official names of this protein?
Protein Smg.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: PPY_DROME
Sequence: MAVLTTHEIDCIIKELTSLNGSECTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPCHKYKMIATDANQMPTNEEE
What are the official names of this protein?
Serine/threonine-protein phosphatase PP-Y.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-Y subfamily.
Protein: PTH_PROM1
Sequence: MLSDELKLLVGLGNPGTEYEKTRHNVGFMVLEEIARKNNCSFRESKKIFGRTCEYGSGIEKTRLLMPNTYMNESGKSVRLAKDWFNFQNNQLIVLVDDMDLPLGKIRVRSKGSSGGHNGLKSIINHLGTAEFKRLKIGIGAPSNDQQERKSKTVSHVLGRFSKEEFIILNFIIQEIISCIESITSNNWEKISTRLNSYKPDN
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_SYNE7
Sequence: MDFYRLLLRPLLLSQLNVDPEWLTRNALGFLATLARSRSPLAANLRSYLRQTYGFQDPRLAMSLWGLTFATPVGLAAGFDKDGIAAPLWSDLGFGFAELGTVTALAQPGNPRPRLFRIPQDLAAFNRMGFNNASAEALADTLRGYFPEGQRSIPIGINLGKSKLTPLSGAVSDYVSSFRSLRSLGDYFVVNVSSPNTPGLRSLQAVTELEPILAALQAENTEQRPLLLKIAPDLVDEEVVAIAHLAQRQQLAGIIATNTTIDKSLLSVEHLPGRREPLATEAGGISGAPLRSRSTEVIRLLHRTTQGQLPIIGVGGIFSAEDAWQKIVAGASLVQVYTGWVYEGPLLVKTIQQGLLERLDSAGLPNLAAAVGSAAIDS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FUCM_ECO57
Sequence: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
What is the function of this protein?
Involved in the anomeric conversion of L-fucose.
What are the official names of this protein?
L-fucose mutarotase, Fucose 1-epimerase, Type-2 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. FucU mutarotase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRR_STRPM
Sequence: MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVFLARRIQERLHQLEGLDLPIGELDIKPFRDDMRVEEDTTLMSVDITGKDVILIDDVLYTGRTIRAAIDNLVSLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSSVEEIVVEVVEVDGRDRVSIIDPT
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: ARCC_STAEQ
Sequence: MAKIVVALGGNALGKSPQEQLELVKNTAKSLVGLITKGHEIVISHGNGPQVGSINLGLNYAAEHDQGPAFPFAECGAMSQAYIGYQLQESLQNELHSMGIDKQVVTLVTQVEVDEGDPAFNSPSKPIGLFYTKEEANRIQQEKGYQFVEDAGRGYRRVVPSPQPISIIELESIKTLVENDTLVIAAGGGGIPVIREQHDSFKGIDAVIDKDKTSALLGADIHCDQLIILTAIDYVYINYHTDQQQALKTTNIDTLKTYIEEEQFAKGSMLPKIESAISFIENNPNGSVLITSLNQLDAALEGKIGTLITK
What are the official names of this protein?
Carbamate kinase.
What is the protein family that this protein belongs to?
Belongs to the carbamate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCTR_RABIT
Sequence: MCPRPGPPLGLWLLLGFACAAHLVGAPPRLCDVLWVLQEERDQCLQELERERLGEEQPVPGCQGLWDNVSCWPSSAPGRMVELECPRFLRMLTNSNGSLFRNCTQDGWTETFPRPDLACGVSMNDSSHERQHAYLLKLKVMYTVGYSSSLVMLLVALGILCAFRRLHCTRNYIHMHLFLSFILRALSNFIKDAVLFSSDDAIHCDAHRVGCKLVMVFFQYCIMANYAWLLVEGLYLHSLLVVSFFSERKCLQGFVVLGWGSPAMFVTSWAVTRHFLEDSGCWDINANAAIWWVIRGPVILSILINFILFINILRILTRKLRTQETRGQDMNHYKRLARSTLLLIPLFGVHYIVFVFSPEGAMEIQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWQQWHLWEPPLCPVALSSSFSNGTSSLNSTKACPSGRSRDTCKVSII
What is the function of this protein?
Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).  Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity).  In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation.  Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation.  Also able to stimulate lipolysis in white adipocytes.  Also plays an important role in cellular osmoregulation by regulating renal water reabsorption.  Also plays a role in the central nervous system: required for synaptic plasticity (By similarity).
What are the official names of this protein?
Secretin receptor, SCT-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFTS_PROMT
Sequence: MAEITAKLVKELRDKTSAGMMDCKKALIENKGDMDKSIEWLRQKGIASAEKKSGRVAAEGAVGSYIHTGSRVGVLLELNCETDFVARGDLFQGLLRDLSMQVAACPSVEYVSVDQIPESIANKEKEIEMGRDDLSGKPDQIKAKIVEGRIGKRLKEMALLEQPFIKDSSINVEELVKQVAGKIGENIRVRRFTRYILGEGIEVQGPDFAEEVASMTSG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOD_HELPH
Sequence: MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMAMGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELSAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: PELF1_ASPTN
Sequence: MKTATFSTLLALSASAVNAQVSGTAFGFAAGTTGGGSAAPETPSSIDELVEWLTDDTARTIMIDRTWDFTGTEGTTDGQCCSTRTTTCEGGTSAGQAWIQDTCDDGTWVSCTYDNAAKNPINVGSNKSIVGVGSDGVLKGKGLRITGGNSNVIIQNIHITDLNPQYVWGGDAITLDDADLVWIDHNKISLIGRQFIVSGWGKAGRVTISNNEFDGVTDWSAGCNGKHYWTLLLIGEQDFYTFSDNWVHDVSGRAPHMGTDMTESTIFFHGVNNYFQNIGGHAFDIDTNTWALLEGNYFESVDTPLTETSLTSGALIYNVPTVDSASACTSPLGYICEWNRLAGSGTWTERTDADVLTMASQYIDSLIDHIPVADVPTTVVANAGVGKL
What is the function of this protein?
Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins (By similarity).
What are the official names of this protein?
Probable pectin lyase F-1, PLF-1.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: EZRA_BACMK
Sequence: MDSILTIVIIVVSSILVLLMIELVIRNRSYKDIEALEQWKQEIKDKPVADELKRVKDLNMTGQTEELFGKWREEWDEIVSTSLPKAEKDLGQARKFASQFSFRKAKHAMKESISGLDDADNRITDILNELQQLLESHEKNSAEIEGLRDTYRSMKKSVLAHRHMYGAAEQKIEEMLDVESEKFKTFEEATDNGDYLKAREIVISLEEGLASLEIVIHQIPDLLVECQATLPVQLEDLLQGHDDMIRQGYVLEYLEIPKEVRDMTTQLHTCLMDIQELHITEAAEKVENLKTRLDSFYDQLEQEVHAKHYVEQKTLSVYEDLEEIRTETIETKIETQLVKQSYQLQDKDIESQKVIEKQMHILMKRFEVLQIRVAEQDIAFSIIREELEEVYEQCETLKVLHAEYKEMLQTMRKEEFEAREKLQEMRNTIFETKRFMQKSNLPGLPESIMEDLQKGQMAMQAVYEQLEVKPLNMNTVNSSLEEAYTVVNGVSEMTEEVIGQAYLVEKLIQYGNRYRSHDENLAESLNYAEKLFREYQYDAALEQAASILEQLEPGVVQKIAEYVDNEQTL
What is the function of this protein?
Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation.  Inhibits FtsZ ring formation at polar sites.  Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
What are the official names of this protein?
Septation ring formation regulator EzrA.
What is the protein family that this protein belongs to?
Belongs to the EzrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Colocalized with FtsZ to the nascent septal site.
Protein: HDAC5_MOUSE
Sequence: MNSPNESDGMSGREPSLGILPRTPLHSIPVAVEVKPVLPGAMPSSMGGGGGGSPSPVELRGALAGPMDPALREQQLQQELLVLKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLLGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGTGPGVSSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMIPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDTSPHGHASLLQHVCSWTGRQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQMQLGKILTKTGELSRQPTTHPEETEEELTEQQEALLGEGALTIPREGSTESESTQEDLEEEEEEEEEEEEDCIQVKDEDGESGPDEGPDLEESSAGYKKLFADAQQLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGSMKSPTDQPTVVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLGKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAMLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLSVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAQEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPSVNAVATLEKVIEIQSKHWSCVQRFAAGLGCSLREAQTGEKEEAETVSAMALLSVGAEQAQAVATQEHSPRPAEEPMEQEPAL
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C.  During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity).  Serves as a corepressor of RARA and causes its deacetylation (By similarity).  In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity).
What are the official names of this protein?
Histone deacetylase 5, HD5, Histone deacetylase mHDA1.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-250 and Ser-488 by AMPK, CaMK1 and SIK1.