PharMolix/UniProtQA huggingface dataset:
Protein: APT_STRU0
Sequence: MNLTHYIASIENYPKEGITFRDISPLMADGKAYSYAIREICQYAADKEIDMIVGPEARGFIIGCPVAVELGIGFAPVRKPGKLPREVVSADYEKEYGLDTLTMHSDAIKPGQRVLIVDDLLATGGTVKATIEMVEKLGGVVAGCAFLIELDGLNGRQALGDIDYKVLMNFPG
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_NEIG1
Sequence: MQYAKISGTGSYLPANRVSNDDLAQKVDTSDEWITARTGIKFRHIAAENEKTSDLAAEAARRALADAKLNINDIDLIIVATATPDMQFPSTATIVQQKLGITNGCPAFDVQAVCAGFMYALTTANAYIKSGMAKNALVIGAETFSRIVDWNDRTTCVLFGDGAGAVVLSASDKPGIIHSKLKADGNYLKLLNVPGQIACGKVSGSPYISMDGPGVFKFAVKMLSKIADDVIEEAGYTAEQIDWIVPHQANRRIIESTAKHLGLSMDKVVLTVQDHGNTSAASIPLALDAGIRSGQIKRGQNLLLEGIGGGFAWGAVLLQY
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL1_HPV32
Sequence: MSVWRPSDNKVYLPPPPVSKVVSTDEYVQRTNYFYHASSSRLLAVGHPYYTIKKTPNRTSIPKVSGLQYRVFRVRLPDPNKFTLPETNLYNPETQRMVWACVGLEVGRGQPLGVGLSGHPLLNRLDDTENGPRYAAGPGTDNRENVSMDCKQTQLCLVGCKPAIGEHWGKGAACSAQSNGDCPPLELQNSVIQDGDMADVGFGAMDFSALQTSKAEVPLDIMNSISKYPDYLKMSAEAYGDNMFFFLRREQMFVRHLFNRAGTLGEPVPEDMYIKASNGASGRNNLASSIYYPTPSGSMVTSDAQIFNKPYWLQQAQGHNNGICWGNQVFLTVVDTTRSTNMTVCATVTTEDTYKSTNFKEYLRHAEEYDIQFIFQLCKITLSVEVMSYIHTMNPDILDDWNVGVAPPPSGTLEDSYRFVQSQAIRCQAKVTAPEKKDPFSDYSFWEVNLSEKFSSDLDQFPLGRKFLLQAGLRARPKLTAVKRTASSSQKSSSPAKRRKTRK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: CH10_POLSJ
Sequence: MKLRPLHDRVIVKRVENETKTASGIVIPDSAAEKPDQGEVLAVGPGKKNDKGDLSPMAVKIGDRVLFGKYSGQTVKVDGDELLVMKEEDLFAVVEK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSH_ECOUT
Sequence: MSKLDLNALNELPKVDRILALAETNAQLEKLDAEGRVAWALDNLPGEYVLSSSFGIQAAVSLHLVNQIRPDIPVILTDTGYLFPETYRFIDELTDKLKLNLKVYRATESAAWQEARYGKLWEQGVEGIEKYNDINKVEPMNRALKELNVQTWFAGLRREQSGSRANLPVLAIQRGVFKVLPIIDWDNRTIYQYLQKHGLKYHPLWDEGYLSVGDTHTTRKWEPGMAEEETRFFGLKRECGLHEG
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_CANAX
Sequence: NVCHGSDSVESANKEIDLWFK
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, NDPK.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_CLOPS
Sequence: MPKVGLFNKEGQQVGDIQLNEQVFGVEVNKYALHQVVVAQLANKRQGTQSAKTRSEVRGGGIKPWRQKGTGRARQGSIRAPQWIKGGVVFAPKPRDYRMSIPKSMRKVAMTSALTSKVADMVVLEDLNFEAPKTKEAVKMLNAFEAKKTLIITAEVNENVYKSARNIEGVTVMPVNNINVYDLLNCKTLMITKEAVNKIEEVYA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: MNMA_CLOPS
Sequence: MTKKKVVIGMSGGVDSSVAAYLLKEQGYDVIGVTMQIWQEDKEYEEREGGCCSLSAVDDARRVAQKLDIPFYVLNFRDSFKRNVIDYFVDEYIQGRTPNPCIACNKYLKFDELLQKAKGIGADYVATGHYAKIEERDGRFQLIRSKDDRKDQTYALYNLTQEQLEHTLMPCGEFTKDKIREIAKEIGLDVHNKKDSEEICFIPDNNHGRYICEAAPNKVRTGNFVDKYGNVLGKHKGIVYYTIGQRKGLGLALGRPVFVTDINPVTNTVVVGPEEDIFKTDLVCKDINFISIDKLEDPMEVEAKIRYSAKPAKATISPMENGRVKVSFEDKQRAITKGQSVVFYKDDLVVGGGIIESLL
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_RAT
Sequence: MASSQLALFSVSDKTGLVEFARNLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLIRVVVCNLYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYGAVAAEMQGSGNKDTSLETRRHLALKAFTHTAQYDEAISDYFRRQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLAIAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGSYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEGEDLVKWKALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH
What is the function of this protein?
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis.  Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR).  Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction.  Also catalyzes the cyclization of FAICAR to IMP (By similarity).  Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).
What are the official names of this protein?
Bifunctional purine biosynthesis protein ATIC, AICAR transformylase/inosine monophosphate cyclohydrolase, ATIC.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: LEUD_ROSDO
Sequence: MDKFTTLTGIAAPLPLINVDTDMIIPKQFLKTIKRSGLGVNLFDEMRYDDDGNEIPDFVLNQDAYRKAEIIVAGDNFGCGSSREHAPWAIKDFGIRCVIAPSFADIFYNNCFKNGILPIALPQEQVDVLMKDAEKGANARMTVDLETQTVTTSDGEVFSFDLDPFKKRCLMEGLDDIGLTMEKISAIDSFEQSAAQARPWV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RS7_CALBD
Sequence: MPRKGPVKKREILPDPVYNDKVVAKLINKVMYDGKKSIAQKIVYGAFDIIREKTGKDPLEVLEAALNNVMPVLEVRPRRVGGATYQVPIEVAPDRRLSLGIRWLVEYARERKDKRTMKEKLAAEIMDAANNTGGAVKKKEDTHRMAEANRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: GEFA_DICDI
Sequence: MITPTSFEPVELLYSKKKVNRTNWKKNVLKSNPEINNLCERIYPINRAIQFGKQFHPGKAEVKQKLDKTAIIQLILQHLSTKGLKQTKQTLEKEARTTTPIVEGLNESRLVTYIRNALKDTDRIYDLSMEHTEYSKEERQSKITEREELLFQMDLLEDEDEDDGVNIWDEPTENIITEKVHTTEYDINKSKENKDDQDDEVVKFASLNKLVEHLTHDSKHDLQFLKTFLMTYQSFCTPEKLMSKLQQRYNCPSGHDEMATRNIQIRVINVLKGWVDNYYSDFDDKLIAMLRTFIDQIQIKFPAPASAVNKSLTKMVEKLSPVNDSKHIFNEKTPEPMVPKNIFSNNLSIYDIDEEEIARQLTLIEFEIYRNIKPPELLNQSWNKTKLKSRAPNVLKMIDRFNSVSMWVATMIIQTTKVKARARMMTRFIKIADHLKNLNNYNSLMAIIAGLNFSSVYRLKYTREELSAQTMRTYSDLEKIMNSEGSFKTYRTRLQNVPPMLPYLGVHLTDLTFIDENPNNFVTDVGGKQVSLINFTKRTLVFKIISLIQETQVVPYNLQPVHQIQEFLLNIRSDLKAHTLDQYQQELYRESLKREPKKAQRSDVL
What is the function of this protein?
Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase (PubMed:17380187).  Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay (PubMed:8793298, PubMed:16234315, PubMed:20493808).  The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway (PubMed:20493808).
What are the official names of this protein?
Ras guanine nucleotide exchange factor A, Aimless, RasGEF domain-containing protein A.
What are the subcellular locations of this protein?
Cell membrane. Note=The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells (PubMed:20493808). Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1 (PubMed:20493808).
Protein: HIS4_SHELP
Sequence: MIIPAIDLIEGQVVRLYQGDYAQQTTFDLSPLAQLQAYQAQGATWLHIVDLTGAKDPDRRQTRLIGELVENLEANIQVGGGIRSEAQVKELLDLGVKRVVIGSLAVKQPELVQSWLETYGSDAICLALDVNINQAGEKIVAVSGWQSGGGKTLESLVATFAPYGLKHALVTDISRDGTLQGSNTQLYQEIVARYPDIEWQASGGIATLDDVSAVRNSGASGIIIGKALLINNFTVQEAIACWPNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_EIMTE
Sequence: MNFQLKNFLILKTLKTFYIEYYKVLIYYLINSIKNYLGDKLYLYYKKNKYTIYILSDFLFFKTTNLTSNITDTVQEFNSKILIFLPLKIKNLKNNKYKIIYYLLGEIPKYTIEKNLIINGLKKTFISKLMFNYIGIFFNKFIKNNNNILYAKIIFNDKFIINIVLEENKCYCIFNNYKYDLICFLYLLGISMQDIFIFSRYNKSFYLKKLLLTLPSLNINNIINYNIFKYLSFFFNLSFKLNTYYIFNKVLNKNNSLYSYIKNFSNSNNLIALDFINILDILLDIKYNKKNITDLDLLEYRSIFTLGNYFTNQYSFYLKKFSNILHNDIFKCIKNLEKYKLNTNSFKSKLYFNLKEYLTVNPLVQYLEQINSFSEIIHKNRVTNYNSKLKQNLQIRNINLNQLGSLCLIDTTEGINCGLVISFTKNIKIEKRNNFQFPYLPVLNIKTKNFITFINSFLQQTYIVLFNNYYLRKNKLFNFFNLSLNKNSFKLKNISIQNMIYIKPMDMFSFAENLIPFIFYNDPARVLMGAKMQSQIVPILKNKRSIIITGYEKNLLNSTNLILKAYQEGIVVYVSSYKIIIRDLYNRKITYFLDKYKRSNHFTILHSKPNVWQGERIFCGQILTSTQDILFSEYIGGNNLLVSYGNFFGYNFEDAIVLNKKIIYSQLFTSLHFKVYEIIFNSLNKFSFEISTINLPKKSFYSKRNLDFFGIIKEGSKVLNNDILVSKIFITNINISLLPLYNLIYILFGKEIKNIKDKSILVSFGNSGRIVKTELFSYSSKIKSYLGYYLKCRVYICKQRLLSVGDKLCGRYGNKGIIAYILPSNDLPYTNTGIIPDIISDSLGIPSRMNIGQLFENLFGLSCYFLNKRLCISNTFNLPKVYIKTILYNYINNIKEKSGNLWIYNSYSPGKILLRDGRQGYKLSEPSFLGISKYSKLIHMIKDKIHYRTIGPYTELMQQPVKGRNKKGGQRFGEMEIWAIEAYGSSYNLRELLNYKSDDIIARTSLLSNLDNNIILDNITTTESFRTLIREIHSMNLNIEAFSSIDQLEGKILPININF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, apicoplast.
Protein: ME53_NPVOP
Sequence: MNWFKENNIFDNKLAKKPAASKLGASPTASRPAGSPAPRRVKPLNKSELAHAAIVKRIGRGSDRLNEISASFVPPEYGFRFDEVPACSHKLEYACERDLREHFLSDNEREAMKSLLRFATNYVLGYINSKDMLTFGRAAGLKLKNELEYVQESECTMCGYKFKDNTRVWMLYVIVRHPPRAASADEEFVPSPNTPDCFEFACCDCADNYPDQLNSHQVYPGINSLHAQRLVEAGFFYQYVFPLEYKTEYFTYNDVKIVHHEGPFKIIQRLLREYKRPNEHIVSITLRTTGGVVLKEINHNVRLMRYRNIYKEPTASDDVNCFTVSSSSELMKALDSGAFDSIQGTVFAEIYGFAIQEFVTGVITFPVRPVKGNYCAVCKKNKMYYSNPVLCCSKCGFTNRYIFNGKYDDLYFHPEAVQTHATHSTHGEFVRYYNLKLHAKICRERLEEYEAQNLQ
What are the official names of this protein?
Early 53 kDa protein, ME-53.
Protein: OBG_BUCA5
Sequence: MKFIDQAIIHVIAGNGGNGCVSFRREKYIPKGGPDGGNGGDGGNIWLEANNNLNTLIDLRFKKKFQAQNGQNGSSRKSSGKKGDDIKIHVPIGTKVINYQTREIIGDLIQHKQKMLIAKGGWHGLGNARFKSSTNRTPRQSTLGSIGEKRDIQLELMLLADVGTLGMPNVGKSTLVTNISGAKTKISDYPFTTLHPVLGSVNIQKNKKFIIADIPGIIKGASYGAGLGIRFLKHLERCKLLLHIIDLVPQNNCHPSDNIKTVLNELKKYSLKLYNKPRWFIFNKIDLLSVEELNQIIKEIIFQFKIHEKYYLISSMKKIGIKKLCSDITKYLKK
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFFO2_HUMAN
Sequence: MVNSLLFGEMALAFGCPPGGGGGGCPGGGGGGGGAGPGPSPVTAALRDDLGSNIHLLKGLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLRYKTFSREQAVQTGPELLRPPAPGGGHGLSSGAAAGANANAVALGGLPPGGGSHPQHYGRLPGTIWSYTQVRRTGGGGVETVQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVASSDSGSTDEIQDEFEREADVEPMVS
What are the official names of this protein?
Intermediate filament family orphan 2.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: FTSK_SPOUR
Sequence: MAKKRAKKRAPAKKRQQKKQQSQMQPLWFEILGVVLIGIAIIMIFEFGIIGRGLSAFSRFLLGNWYVALPFLIIVQALIFMIKRQIGGYKHRIVIGCLFILGSMLLFSHVHLFQTLYESKVLMSNSALKETWKVLITNDGIHDQTGTLGGGMLGAVLFAMFYSLVDSSGATVAGVLLLLIGIILLTGKALIPFLVEQTPILMNDIKKKWAAREKKSVKSPEEKRKESARSNRKSKPKPVDTSEMEAVQENPEPASEPIISSFTAKIEQATQPEIVQEKQSKAQEDSTLDPKDPVTDYPVMGGEQENESYVLPSAKLLEPPVASDQSGEYDLIQANAKKLEKTFLSFGVKTRVTQVHLGPAVTKYEILPDTGVKVSRIVSLADDIALALAASGIRIEAPIPGKSAVGIEVPNNAVAMVSLREVLESKENNPPEAKLLVGLGRDVTGQAMMTELNKMPHVLIAGATGSGKSVCVNGIIMSIIMRAKPHEVKMMMIDPKMVELNVFNGIPHLLAPVVTDPRKAAQALQRVVSEMERRYELFSHTGTRNIEGYNNHIEQWNEDHDEKHPRMPYIVVIVDELADLMMVASSDVEDSITRLAQMARAAGIHLIIATQRPSVDVITGIIKANIPSRIAFAVSSAIDSRTILDGAGAEKLLGRGDMLFLPAGASKPTRIQGAFVSDEEVEAVVNFVIEQQKAQYQEEMIPTEVEVVAPHEETDELYDEAVQMVVDMQTASVSMIQRRFRVGYARAARIVDQMEARGVVGPPEGSKPRHVLLTKSKLEM
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).  Also involved in chromosome segregation into the prespore compartment during sporulation.
What are the official names of this protein?
DNA translocase FtsK, DNA translocase SpoIIIE.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: SPX5_ORYSJ
Sequence: MKFGKRLKRQIEESLPEWRDHFLNYKELKRRLNAVSSPDPAAEARFLALLHAEVDKFNAFFLEQEEDFVIRQRELQERIQSSSSAAAEMEGRVRREVVDLHGEMVLLLNYSSINYTGLAKILKKYDKRTGGVLRLPVIAGVLRQPFYATDLLSSLVRDCEAIMDAVFPSLPSPSAAAAAAARAAAEQAIFRNTVAALLTMQEVRSGSSTYGHFSLPPMTPLPDSDWLIQSVQPPPPPPPSSPLIIPT
What is the function of this protein?
Functional repressor of PHR2 (PubMed:24368504).  Involved in maintaining cellular Pi homeostasis when plants are exposed to an external change in Pi (PubMed:24368504).  Negatively regulates root-to-shoot Pi translocation redundantly with SPX3 (PubMed:24368504).
What are the official names of this protein?
SPX domain-containing protein 5, Protein SPX DOMAIN GENE 5, OsSPX5.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: TRYA_MANSE
Sequence: MRLFLALLALGFAAVAAVPAYPQRIVGGSTTTIQQYPTIVALLFSRNGNTFFQACGGIILNNRNVLTAAHCPHGDAVNRWRVRSGSTYANSGGAVHNLNRVRIHPNFNRRTLDNDIAIMRTTSNIAFNNAAQPARIAGANYNLGDNQVVWAAGWGAIRSGGPSSEQLRHVQVWTVNQATCRSRYASIGRSVTDNMLCSGWLDVGGRDQCQGDSGGPLYHNGVVVGVCSWGEECALARFPGVNARVSRFANWIRNNS
What are the official names of this protein?
Trypsin, alkaline A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: HYAL_ECHOC
Sequence: MYHLWIKCLAAWIFLKRFNGVHVMHAKAPMYPNEPFLVFWNAPTTQCRLRYKVDLDLKTFHIVANANDTLSGSAVTIFYPTHLGIYPHIDDRGHFFHGIIPQNESLTKHLDKSKSDINRIIPLKTFHGLGVIDWENWRPQWDRNWGNKNVYRNRSIQFARDLHPELSENKIRRLAKAEYEKAAKSFMRDTLLLAEEMRPDGYWGYYLYPDCQNYDYKTKGDQYTGKCPDIEMSRNDQLLWLWRESTALFPNVYLEIILRSSDNALKFVHHRLKESMRIASMAREDYALPVFVYARPFYAYTFEPLTQEDLVTTVGETAAMGAAGIVFWGSMQYASTVDSCQKVKKYMNGPLGRYIINVTTAAKICSHALCRKNGRCVRKHSDSNAFLHLFPESFRIMVHANATEKKVIVKGKLELENLIYLRENFMCQCYQGWQGLYCEEYSIKDIRKI
What is the function of this protein?
Snake venom endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments.  In venom, it is not toxic by itself, but increases the diffusion of other venom proteins by degrading the extracellular matrix.  In addition, it displays antiedematogenic activity (By similarity).
What are the official names of this protein?
Hyaluronidase, Hy, Hyaluronoglucosaminidase, Venom spreading factor.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 56 family.
What are the subcellular locations of this protein?
Secreted.
Protein: EST5_RAT
Sequence: MCLRSLFLVSLATCVVCGNPSSPPVVDTMKGKVLGKYASLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQDATKGQRMNDLLTNRKEKVHLQFSEDCLYLNIYTPADFTKDSRMPVMVWIHGGGLTQGGASTYDGQVLSAYENVVVVAIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSPLSKNLYHRAISESGVVLITELFTKDVRPAAKQIADMAGCKTTTSAIIVHCLRQKTEEELLEIMEKMNLIKLSSQRDTKESYHFLSTVIDDVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMRFVPPDVKLDKKMAIMLLEKFASIYGIPEDIIPVAIEKYRKGSDDPIKIRDGILAFIGDVLFCIPSVMVSRDHRDAGAPTYVYEYQYYPSFSSPQRPKDVVGDHADDVYSVFGAPILRDGASEEEIKLSKMVMKFWANFARNGNPNARGLPHWPQYDQKEEYLQIGATTQQSQRLKAEEVAFWTQLLAKRQPQPHHNEL
What is the function of this protein?
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
What are the official names of this protein?
Liver carboxylesterase B-1, Liver microsomal carboxylesterase.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Note=Microsomal membrane, lumen of endoplasmic reticulum.
Protein: RL15_PHOV8
Sequence: MNLSNLKPAEGSTKTRKRIGRGPGSGLGGTSTRGHKGAKSRSGYSKKIGFEGGQMPLQRRVPKFGFKNINRVEYKAINLETIQKLAEAKNLTKVGMNDFIEAGFISSNQLVKVLGNGSLTTKLDVEANAFSKSAVAAIEAVGGNAVKL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: TGT_HYDCU
Sequence: MKFELDKQDGRARRGRLIFKRGVVETPAFMPVGTYGSVKGMMPEEVADTGAQIILGNTFHLSIRPGTDIIEQHGDLHDFMNWKGPILTDSGGFQVFSLGKMRKITEEGVHFRNPVNGSKIFMGPEESMDVQRKLGSDIVMIFDECTPYPATHDVAADSMRLSLRWAERSKQAHGDNPSALFGIVQGGMYEDLRQESIKGLTDIGFDGYAIGGLSVGEPKEEMMGTLDFTEPHMPKDKPRYMMGVGKPEDIVEAVRRGIDMFDCVIPTRNARNGFLFTHSGVVKIRNAVNKTSLEPLDAKCDCYTCQNYTRAYLHHLDKCGEIQGARLNTIHNLHYYQLLMKGLREAIASETLDTFVSEFYQARGEDVPAL
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PYRF_SHIF8
Sequence: MTLTASSSSRAVTNSPVVVALDYHNCDDALSFVDKIDPRDCRLKVGKEMFTLFGPQFVRELQQRGFDIFLDLKFHDIPNTAAHAVAAAADLGVWMVNVHASGGARMMTAAREALVPFGKDAPLLIAVTVLTSMEASDLADLGVTLSPADYAERLAALTQKCGLDGVVCSAQEAVRFKQVFGQEFKLVTPGIRPQGSEAGDQRRIMTPEQALAAGVDYMVIGRPVTQSVDPAQTLKAINASLQRSA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: RL19_CUPMC
Sequence: MNIIEQIEKEEIARLTANKTIPAFAPGDTVIVNVNVVEGNRKRVQAYEGVVIAKRNRGLNSSFIVRKISSGEGVERTFQLYSPLIAGIEVKRRGDVRRAKLYYLRERSGKSARIKEKLVMKAKPAAVAAE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.