PharMolix/UniProtQA huggingface dataset:
Protein: GLD2_HUMAN
Sequence: MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKRQRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELCRTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSPAIQLHLVHQAPCNVPPYLSKNESNLGDLLLGFLKYYATEFDWNSQMISVREAKAIPRPDGIEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWHRLKNKRDLNSILPVRAAVLKR
What is the function of this protein?
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail.  In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731).  Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165).  Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856).
What are the official names of this protein?
Poly(A) RNA polymerase GLD2, hGLD-2, PAP-associated domain-containing protein 4, Terminal nucleotidyltransferase 2, Terminal uridylyltransferase 2, TUTase 2.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: KUP1_LEGPA
Sequence: MKKNRFTYGLALGALGIVFGDIGTSPLYALKVTLSGIPINQFNILGVLSLIFWSLIIVVSFKYLMIIFRADNDGEGGILALLALMKHKSTKYQPVFYIVAIFGAGLLLGDGMLTPAISVVSAVEGLGTLSDKLYPYVLPIASLILVLLFSLQAKGTARIGYLFGPLILIWFITIAILGILQILEHPVVLKAINPYYAIAFLVDEGLRGYFLLGGIFLVVTGGEALFADIGHFGKNPIRFSWFFIALPCLLLNYFGQGANLIVRPEEISNPFFMIAPPWFYLPLIIIATVATVIASQAVISATFSLTKQAVLLGLCPKIPIVQTSMLHSGQIYVPQINFILFIGTMAFCLAFKTSDNLAHAYGIAVNLEMLLVDAMVAYAAVSIWRWSTFNVIFLFGLFLLIDLAFLGANTHKFITGGWVPIVLAFFIAFIMYSWRYGLEYLRDNFYMNKEDISKILKQLQYKSLNQLPGVSAIFITDVYDKSGGSFLHFLKLNRSVPENVLIVNYIVDNIPYVHYSQRYEIVCLDEKVCKLVIHYGFMETINIPRSLEKACNKNILPFKFNVDTATFMVEIPNIMASKEKRSLSFYWQEKLFAFLMRNYSANLNIEFYKLPYNRTIAIGTYCIL
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 1.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTGES_MOUSE
Sequence: MPSPGLVMESGQVLPAFLLCSTLLVIKMYAVAVITGQMRLRKKAFANPEDALKRGGLQYYRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPLIAWIHFLVVLTGRVVHTVAYLGKLNPRLRSGAYVLAQFSCFSMALQILWEVAHHL
What is the function of this protein?
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway (PubMed:10869354, PubMed:11795891).  Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:11795891, PubMed:10869354).  Plays a key role in inflammation response, fever and pain (PubMed:12835414, PubMed:14566340).  Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2.  In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
What are the official names of this protein?
Prostaglandin E synthase, mPGES-1, Glutathione peroxidase PTGES, Glutathione transferase PTGES, Microsomal prostaglandin E synthase 1.
What is the protein family that this protein belongs to?
Belongs to the MAPEG family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cytoplasm, perinuclear region. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment.
Protein: GRNLG_PERFH
Sequence: MCSISQKVVIGLNKAAANNCLQNLDRRGFKTRRVSSSEAASCLRASSSLQLDVKPVEEGRRSGNYQPSIWDFNYVQSLNTPYKEERYLTRHAELIVQVKPLLEKKMEATQQLELIDDLNNLGLSYFFQDRIKQILSFIYDENQCFHSNINDQAEKRDLYFTALGFRLLRQHGFNVSQEVFDCFKNDKGSDFKASLSGNTKGLLQLYEASFLVREGEDTLELARQFATKFLRRKLDEIDDNHLLSRIHHSLEIPLHWRIQRLEARWFLDAYATRHDMNPIILELAKLDFNIIQATHQEELKDVSRWWQNTRLAEKLPFVRDRLVESYFWAIALFEPHQYGYQRRVAAKIITLATSIDDVYDIYGTLDELQLFTDNFRRWDTESLGGLPYSMQLFYMVIHNFVSELAYEILKEKGFIAIPYLQRSWVDLAESFLKEANWYYSGYTPSLEEYIDNGSISIGAVAVLSQVYFTLANSIEKPKIESMYKYHHILRLSGLLVRLHDDLGTSLFEKKRGDVPKAVEICMKERNDTEEEAEEHVKYLIREAWKEMNTATAAAGCPFMDELNVAAANLGRAAQFVYLDGDGHGVQHSKIHQQMGGLMFKPYV
What is the function of this protein?
Monoterpene synthase (mono-TPS) involved in the biosynthesis of monoterpenes natural products (PubMed:20447664).  Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) into geraniol (PubMed:20447664).
What are the official names of this protein?
Geraniol synthase Tps-5031G8, chloroplastic, PsTps-5031G.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsb subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PA2A2_PSETE
Sequence: MHPAHLLVPLGVCVSLLGAARIPPLPLSLVEFRILIKCANHNSRNVLDYADYGCYCGKGGSGTPVDELDRCCQAHDYCYDDAEKLPACNYRFSGPYWNPYSYKCNEGEVTCTDDNDECKAFICNCDRTAAICFAGAPYNDENFMITIKKKNICQ
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows moderate enzymatic activity and exhibits procoagulant activity.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 2, svPLA2, Phosphatidylcholine 2-acylhydrolase, Pt-PLA2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NS1_I83A4
Sequence: MDSNTVSSFQVDCFLWHVRKRFADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILEEEPDEALEMTIASVPAPRYLTDMTLEEMSRDWFMLMPKQKVAGSLCIRMDQAIMDKNITLKANLSVISDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAIGVLIGGLEWNDNTIRVSETLQRFAWRSSNENGRPPLPPKQKRKMARTIESEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: TAL_SHEFN
Sequence: MANALAQLKSFTTIVADTGDIEAIKRYQPEDATTNPSLILKASQIPEYAFLIENAIEWAKTQSHSIEQQIEDAGDKLAVNIGVEILKLVPGRISTEVDARLSFDKQRSIDKAHKLIKLYKDAGIDKSRILIKLASTWEGICAAKELEQEGINCNLTLLFSFAQARACAEAGVYLISPFVGRILDWYKKDTGQDYTAETDPGVVSVTEIYNYYKQNGYNTVVMGASFRNIGEIIELAGCDRLTIGPALLEELANTDVEIIQKLVATPATQSAPAALTEEQFRWVFNEDPMAVDKLAEGIRNFAIDQGKLEVMLKTKLS
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFTNT_MYCTU
Sequence: MTIGVDLSTDLQDWIRLSGMNMIQGSETNDGRTILWNKGGEVRYFIDRLAGWYVITSSDRMSREGYEFAAASMSVIEKYLYGYFGGSVRSERELPAIRAPFQPEELMPEYSIGTMTFAGRQRDTLIDSSGTVVAITAADRLVELSHYLDVSVNVIKDSFLDSEGKPLFTLWKDYKG
What is the function of this protein?
Antitoxin for tuberculosis necrotizing toxin (TNT).  Acts by binding directly to TNT, which inhibits NAD(+) glycohydrolase activity of TNT and protects M. tuberculosis from self-poisoning.
What are the official names of this protein?
Immunity factor for TNT, IFT, Tuberculosis necrotizing toxin antitoxin, TNT antitoxin.
Protein: ZNG1_DANRE
Sequence: MEDEDECPELVPIKEKPSGPTAQIPVTIITGYLGAGKTTLLNYILTEQHNKRIAVILNEFGEGSALEKSLAVSQAGELYEEWLELRNGCLCCSVKDNGLKAIENLMEKKGKFDYILLETTGLADPGAVASMFWVDAELGSDVYLDGIVTVIDAKYGLQHLTEEKPEGLINEAARQIALADLTIINKTDLVHETELLKLRDTVRSINALVKILETQKSRVDLSEVLDLHSFDTKDGERLTKKLQLVKTSQPHLDKSMLTITFEVPGSVSEDLLNIFIQELLWEKTFKNKAGLPMTVIRLKGILSLQQKQKKVMLQGVHELYELEETPEFWADQEPRLNRLVFIGRNLDGEILKKEFISAVSNKDSVE
What is the function of this protein?
Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (PubMed:35584702).  Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702).  Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (PubMed:35584702).  After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1 to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis.  GTP/GDP exchange is required for release of active METAP1 (By similarity).
What are the official names of this protein?
Zinc-regulated GTPase metalloprotein activator 1, Cobalamin synthase W domain-containing protein 1, COBW domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
Protein: ILVC_SULTO
Sequence: MAKVYIDKDASLDPIKDKTIAVLGYGSQGRAWALNLRDSGLKVLVGLEREGNSWKVAESDGFNPMHTEDAVKKSDIVIFLVPDMVQRYVYRERVAPYLRDGMDLVFAHGFNIHYKLIEPPKTVDVYMIAPKGPGPIVREYFAKGGGVPALVAVHQNYSGKAFEKALAIAKALGATRAGVIETTFKEETETDLFGEQVDLVGGITQLMRTAFQVLVEAGYQPEIAYYETINEMKMIVDLIYEKGFTGMLKAVSETAKYGGFTAGKYVINEDVKKRMKEVLDRIRSGKFAEEWIEEYNKGAPTLVNGMKEVENSLEEQVGRQIREISLRGKPKS
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RL15_STAES
Sequence: MKLHELKAAEGSRRVRNRVGRGAATGNGKTSGRGQKGQKARSGGKVRPGFEGGQLPLFRRLPKRGFTNINRKEYAIVNLDQLNKFEDGTEVTPALLVESGVVKNEKSGIKVLGNGSLDKKLTVKAHKFSASAAEAIDAKGGAHEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: SYGB_DECAR
Sequence: MSSKNLLVELFVEELPPKALKKLGEAFSAALANSLKNAGLAPATASITAYASPRRLAAHVTDVAAVAADKPVAQKLMPVAVGLDAAGNATPALLKKLAGLGIDADAAASVVASLRRENDGKADVLFFDSLAKGATLAEGLQKAIEAALAALPIPKVMTYQLQDGWSSVNFVRPAHGLVALHGGDVVPVAVLGLNAGRETHGHRFEATVDPVVFANADEYASKLATDGAVIASFAERRAEIARQLEGAAAKAGQATGAALRPIDDEALLDEVTALVERPNVLIGQFEQEFLAVPQECLILTMKANQKYFPLLDATGKLTNKFLVVSNISPEDASAVIGGNERVVRPRLADAKFFFDQDRKKSLESRVIGLSKVVYHNKLGTQGERMQRVAAIARAIGESLGGEALALHAEQAAVLAKADLLTDMVGEFPELQGTMGRYYALHDGLAAEIADAVEDHYKPRFAGDTLPRGIVGTVVALADKLETLVGMFGIGQIPTGDRDPFALRRHALGVIRMLAENNLALPLDHLLQTAAAPFASVDGFKAAEAPLADFIYDRLAGSLREQGYTAQEVDAVVSQRPQRLGDIPKRLAAVRAFSGLPESAALAAANKRVGNILKKVENAVEAVVDNALLKEAAEIALHDALVEVVPQADAAFVTGDYSESLQALAALRAPVDAFFDDVMVNAEDPALRANRLGLLAKLHAAMNQVADISKLSA
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UHRF1_RAT
Sequence: MWIQVRTMDGKETHTVNSLSRLTKVQELRKKIEELFHVEPQLQRLFYRGKQMEDGHTLFDYDVRLNDTIQLLVRQSLALPLSTKERDSELSDSDSGYGVGHSESDKSSTHGEGTADGDDKTVWEDTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKKALSEEEPCSSSAIMAPEDDIMYHIKYDDYPEHGVDIVKAKNVRARARTVIPWEDLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQTRTARELYGNVMLLNDSQLNNCRIIFVDEVLKIELPNERSPLIGSPSRRKSGPSCQYCKDDENKPCRKCACHICGGREAPEKQVLCDECDMAFHLYCLQPPLTCVPPEPEWYCPSCRTDSSEVVQAGEKLKKSKKKAKMASATSSSRRDWGKGMACVGRTTECTIVPANHFGPIPGVPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDNGNFFTYTGSGGRDLSGNKRTAGQSSDQKLTNNNRALALNCHSPINEKGAEAEDWRQGKPVRVVRNMKGGKHSKYAPAEGNRYDGIYKVVKYWPEKGKSGFIVWRYLLRRDDTEPEPWTREGKDRTRQLGLTMQYPEGYLEALANKEKNRKRPAKALEQGPSSSKIGKSKRKSTGPATTSPRVSKKSKLEPYTLPLQQANLIKEDKGNAKLWDDVLSSLQDGPYQIFLSKVKEAFQCICCQELVFRPVTTVCQHNVCKDCLDRSFRAQVFSCPACRYDLDHSSPTRVNQPLQTILNQLFPGYGSGR
What is the function of this protein?
Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification.  Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication.  In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins.  Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication.  Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications.  Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML.  It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo.  Plays a role in DNA repair by cooperating with UHRF1 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase UHRF1, Liver regeneration-related protein LRRG126, RING-type E3 ubiquitin transferase UHRF1, Ubiquitin-like PHD and RING finger domain-containing protein 1, Ubiquitin-like-containing PHD and RING finger domains protein 1.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions (By similarity).
Protein: RS5_YERE8
Sequence: MSHIEKQAGELQEKLIAVNRVSKTVKGGRIFSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRAMINVALDNGTLQHPVKGAHTGSRVFMQPASEGTGIIAGGAMRAVLEVAGVHNVLAKAYGSTNPINVVRATIAALEDMKSPEMVAAKRGKSVEEILGK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: SPRE_MERUN
Sequence: MESGGLGCAVCVLTGASRGFGRALAPRLAQLLAPGSVLLLCARSDSALRRLEEELGAQQPGLRVVRAAADLGTEAGLRQVLRAVRELPKPEGLQRLLLINNAGTLGDVSKGVLNVNDPAEVNNYWALNLTSMLCLTSGTLNAFPDSPGLSKTVVNISSLCALQPFKGWGLYCTGKAARDMLCQVLAAEEPSVRVLSYAPGPLDTDMQQLARETSMDPELRNRLQRLKSEGELVDCGTSAQKLLNLLQKDTFQSGAHVDFYDN
What is the function of this protein?
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.  The enzyme also catalyzes the reduction of benzil to (S)-benzoin.
What are the official names of this protein?
Sepiapterin reductase, SPR, Benzil reductase ((S)-benzoin forming).
What is the protein family that this protein belongs to?
Belongs to the sepiapterin reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARA_LACPL
Sequence: MKRYLVLEDGTIYPGTGFGATTATVGELVFNTGMSGYQESITDQSYNGEILMFTYPLIGNYGINRDDHESIKPTCKGVVVHEVARRASNWRNAQSLDDYLKQNAIPGIMDIDTRAVTKHIRTKGAMKATIVDNVLPDTVDRLKVTELNRAVVAQSSTNNAYPNPATGPNVVVVDFGLKHSILRELAKRQCNLTVLPYNTTASEIMALNPDGVMLTNGPGDPKDVPGALEMIREVEKHVPLFGICLGHQLFALANGADTFKMKFGHRGFNHPVREIATGRIDFTSQNHGYAVDRDSLAQTDLLITHEEINDGTVEGLRHRDYAAFSVQYHPDAAPGPHDADHIFDEFIDLMAANQATQKGSQFNA
What are the official names of this protein?
Carbamoyl-phosphate synthase pyrimidine-specific small chain, Carbamoyl-phosphate synthetase glutamine chain, CPS-P.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: IHFB_ROSDO
Sequence: MIRSELIQKIADENPHLYQRDVERIVNTIFEEVTGAMARGDRVELRGFGAFSVKKRDARIGRNPRTGETVHVEEKHVPFFKTGKLLRDRLNGKS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: MURD_LISMF
Sequence: MKKIEMYHHKKVLVLGLARSGVSAATIMHKLGAFVTVNDQKPFSENPEAQGLLEQGIKVICGSHPIELLDEGFELVIKNPGIPYNNPMIEKALKLKIPVITEVELAYQISEAPIVGITGTNGKTTTTTIIHHMLNAHKENSSLLAGNIGFPASAVAENATSDQYISMELSSFQLMGVETFKPHISVITNIYEAHLDYHTDRSEYVQAKWHIQKNQTADDFLVINWDQEELKNLTKQTKAQVIPFSTTQRLGQGSYVQNGNIMFNDEVIGARDNILLPGEHNLENVLASVAVAKTLGVTNEEIMHVLETFKGVEHRTQFVVEWQGRKFYNDSKATNILATQSALKGFKNPVVLLAGGLDRGNSFDELLPFFKNVKALIVFGETADKIGRVGKIAGIDVHYVDNVEAAVPVAYRESAPGDIILLSPACASWDQYRTFEVRGNAYMDAIGELIEEVEK
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_THEM4
Sequence: MALKFELLKTHKNARRGRIYLPHGVVETPTFMPVGTNANVKLMTPENLEEIGAQIILANAFHLYLKPGMEVLRHHNGIHDFMNWEKPILTDSGGFQVFSLRKGRKITKEGVLIKSPLDGSMRMITPELSMEIQNSIGSDIVMAFDYCAEPGISHQDAVVALELTTLWAERSLKSIRNMSDQSIFGIVQGAFYKDLRERSAKEITSMDFDGFAIGGLSVGEGYDITLEMTEFTVPLLPENKPRYFMGAGAPRLIVDLVNLGVDIFDSVLPTRVARHGQALTWKGKMNVRAAKYKFDKSPIDDECTCYTCRNYSRSYIRHLFDRGEVLGQMLLTIHNLHFMMDLSKKIRESIDGGYFEKLRGEVLKYYD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: CE064_HUMAN
Sequence: MLAPLFLCCLRNLFRKLISFQPPQLGRTNMHYSKLPRTAIETEFKQNVGPPPKDLTAEVYFPSIKSRSHLPAVFYNQYFKHPKCVGEYGPKNGAERQIEERKVLPTTMMFSMLADCVLKSTPIPILGVAM
What are the official names of this protein?
Uncharacterized protein C5orf64.
What are the subcellular locations of this protein?
Secreted.
Protein: CD2H_ASFM2
Sequence: MIIILIFLIIPNIVLSIDYWVSFNKTIILDSNITNDNNDINGVSWNFLNNSLNTLATCGKAGNFCECSNYSTSLYNIAHNCSLTIFPHNDVFGTPYQVVWNQIINYTIKLLTPVTPPNITYNCTNFLITCKKNNGTNTIIYFNINDTNVKYTNESILEYNWNNSNFNNFTATCIINNTINSSNDTQTIDCINTLLSSYLDFFQVASYMFYMIIFIATGIIASIFISIITFLSLRKRKKHVEEIESPSPSESNEEEQCQHDDTTSIHEPSPREPLLPKPYSRYQYNTPIYYMRPLTQPLNPSPLPKLCPPPKPCPPPKPCPPPKPCPPPKPCPSSESCSPPESYSLPKPLPNIPLLPNIPPLSTQNISLIHVDRII
What is the function of this protein?
May play an immunosuppressive role by inhibiting lymphocyte proliferation and subsequently facilitating viral replication and generalization of infection (PubMed:9525608).  Responsible for viral hemadsorption, which may help viral spread (By similarity).  Increases virus replication in the tick vector at the step of virus uptake or replication in the tick gut (By similarity).  May play a role in the host Golgi reorganization to yield viral factories (By similarity).  May play a role in host cell penetration (By similarity).
What are the official names of this protein?
CD2 homolog, CD2H, 5HL, CD2v, T-lymphocyte CD2 receptor-like protein, CD2-like protein, pEP402R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus CD2 homolog protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein. Virion membrane. Host Golgi apparatus. Note=Localizes around the cytoplasmic viral factories which are probably derived from the host Golgi membrane (By similarity). Both proteolytic fragments localize to membrane compartements (PubMed:21248037). A minor fraction localizes on the host plasma membrane and on the outer viral envelope of budding particles (By similarity).
Protein: HSPA_BRADU
Sequence: MRTYNISPLWRSTIGFDRVFDLVDAARHTAGEANYPPCNVERLSDDRYRISLALAGFSPDEITVTAEQSVLTIEGRKGEKGRRDFVYRGISSRPFKRQFGLAAHVRVEGARFDNGLLQIELVREIPDAMKPRRIPIDNLAASDVQQIEREAA
What are the official names of this protein?
Small heat shock protein HspA.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: HDFR_ESCF3
Sequence: MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARKEVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDTHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGTDEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLHTVVDSTTLSRPLYAIWLQNSDKHALIRDLLKINVLDEVY
What is the function of this protein?
Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
What are the official names of this protein?
HTH-type transcriptional regulator HdfR, H-NS-dependent flhDC regulator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: Y2257_LISMF
Sequence: MSVLFTILLMAVIGGFIGAMTNYIAIRMLFRPYKAIYLFNKRLPFTPGLIPKRRDELAEHIGKVVVSHLLTEDAIRARLLDENLQKEITDTITKMFHEKMQLETTPNELLHHFGYENAEIRSMTWVEKTLEKEINHFLTTKKTTKMSDLIPTMLESELTTKLPHVTERITSKMTLFVSSEEGKIQIKQMLQKFFEEHGKMGSMARMFINIDSFSEKIQQEGLKLIGQEDTKNLINQLLTTEWKNFEAKELQELIPTEKQAHLAGQLTSELIQTFPHEKLFNQPIQVMLRGYEAAITEKVIPFAVERMLDFVATHSAEIVERMDLAKLVETQIATFSLPEIEKLVVEISGRELKMITYLGGILGGFIGIIQGVLAMWI
What are the official names of this protein?
UPF0754 membrane protein LMOf2365_2257.
What is the protein family that this protein belongs to?
Belongs to the UPF0754 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.