PharMolix/UniProtQA huggingface dataset:
Protein: ACSA_MYCTO
Sequence: MSESTPEVSSSYPPPAHFAEHANARAELYREAEEDRLAFWAKQANRLSWTTPFTEVLDWSGAPFAKWFVGGELNVAYNCVDRHVEAGHGDRVAIHWEGEPVGDRRTLTYSDLLAEVSKAANALTDLGLVAGDRVAIYLPLIPEAVIAMLACARLGIMHSVVFGGFTAAALQARIVDAQAKLLITADGQFRRGKPSPLKAAADEALAAIPDCSVEHVLVVRRTGIEMAWSEGRDLWWHHVVGSASPAHTPEPFDSEHPLFLLYTSGTTGKPKGIMHTSGGYLTQCCYTMRTIFDVKPDSDVFWCTADIGWVTGHTYGVYGPLCNGVTEVLYEGTPDTPDRHRHFQIIEKYGVTIYYTAPTLIRMFMKWGREIPDSHDLSSLRLLGSVGEPINPEAWRWYRDVIGGGRTPLVDTWWQTETGSAMISPLPGIAAAKPGSAMTPLPGISAKIVDDHGDPLPPHTEGAQHVTGYLVLDQPWPSMLRGIWGDPARYWHSYWSKFSDKGYYFAGDGARIDPDGAIWVLGRIDDVMNVSGHRISTAEVESALVAHSGVAEAAVVGVTDETTTQAICAFVVLRANYAPHDRTAEELRTEVARVISPIARPRDVHVVPELPKTRSGKIMRRLLRDVAENRELGDTSTLLDPTVFDAIRAAK
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.  M. tuberculosis may use AcsA for both acetate and propionate assimilation (By similarity).
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: ALL4_CALVO
Sequence: DRPYSFGL
What is the function of this protein?
May act as a neurotransmitter or neuromodulator and play a role in the integration of information within the brain.  May be involved in the control of visceral muscles due to its ability to behave as potent inhibitors of peristaltic movements.  May also fulfill a neurohormonal role on muscles of the gut and heart.
What are the official names of this protein?
Callatostatin-4, Leu-callatostatin-4.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KDPA_RHORT
Sequence: MDANAILQVVLFCAIILGLTPLLGGYMARVFSGERVLLSVVFGPLERGLYRLSGVRPKEEQHWAAYALSMLVFNLAGLLGLYLILRVQGWLPLNPAGLGAVAPDLAFNTAVSFVTNTNWQAYGGESTLSYFSQMVGLTVQNFVSAATGIAVLVALIRGFARRSARTLGNFWVDLTRTVLYLLLPLAFVTALVLVWQGAPQTLGDYVQAAPLEGGSQVIALGPVASQEAIKQLGSNGGGFFSVNSAHPFENPTPLSNLIEMVLLLAVAAGLTNTFGRMVGDTRQGWALFAAMSLMFVVGLGVTLWQESAANPAMVVAGIEAGGGNMEGKEVRLGVANSAIWAVATTAASNGSVNAMHDSFMPLAGMVPMINMMLGEVIFGGVGAGLYGMLIFVMVTVFIAGLMVGRTPEYLGKKIEAREMKLAVISLLVPPLCILGFGAVALTWPQAAASVQDPGPHGLTEALYAYVSGTANNGSAFAGFAANVFPHNLMIGLAMLIGRFLVILPVLAIAGSLGAKKIVPVSAGTFPTHGGLFIGLLVGVIVVVGGLTYFPVLALGPILEQLMLRSGSLF
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS16_LEGPH
Sequence: MVVIRLSRAGAKKRPFYHMVVTDSRKRRDGNYIERIGYFNPVARGQEVKLHIDMDKMTHWQKVGAQLSDRVSALLKEHSKKSETAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: YOHJ_ECO27
Sequence: MSKTLNIIWQYLRAFVLIYACLYAGIFIASLLPVTIPGSIIGMLILFVLLALQILPAKWVNPGCYVLIRYMALLFVPIGVGVMQYFDLLRAQFGPVVVSCAVSTLVVFLVVSWSSQLVHGERKVVGQKGSEE
What are the official names of this protein?
UPF0299 membrane protein YohJ.
What is the protein family that this protein belongs to?
Belongs to the UPF0299 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y061_SULTO
Sequence: MDLQNILENNDRVFKFLEVKILDVKPGYSKIQIPYKEEFCRRGNVLNGGIIMTAIDFAGGLATLSVNDGIDQVTQELKVNFLEPMYKGPFTVEGKVVRKGRTAVIVQIEFRDSEGKLGAIALGTWYIIRDRVVKKEGG
What are the official names of this protein?
Putative esterase STK_00610.
What is the protein family that this protein belongs to?
Belongs to the thioesterase PaaI family.
Protein: BRXC_ECOHS
Sequence: MNIEQIFKKPLKRNINGVVKAEQTDDASAYIELDEYVITRELENHLRHFFESYVPATGPERIRMENKIGVWVSGFFGSGKSHFIKILSYLLSNRKVTHNGTERNAYSFFEEKIKDALFLADINKAVHYPTEVILFNIDSRANVDDKEDAILKVFLKVFNERIGYCADFPHIAHLERELDKRGQYETFKAAFADINGSRWEDERDAYYFISDDMAQALSQATQQSLEASRQWVEQLDKNFPLDINNFCQWVKEWLDDNGKNILFMVDEVGQFIGKNTQMMLKLQTITENLGVICGGRAWVIVTSQADINAAIGGMSSRDGQDFSKIQGRFSTRLQLSSSNTSEVIQKRLLVKTDEAKAALAKVWQEKGDILRNQLAFDTTTTTALRPFTSEEEFVDNYPFVPWHYQILQKVFESIRTKGAAGKQLAMGERSQLEAFQTAAQQISAQGLDSLVPFWRFYAAIESFLEPAVSRTITQACQNGILDEFDGNLLKTLFLIRYVETLKSTLDNLVTLSIDRIDADKVELRRRVEKSLNTLERLMLIARVEDKYVFLTNEEKEIENEIRNVDVDFSAINKKLASIIFDDILKSRKYRYPANKQDFDISRFLNGHPLDGAVLNDLVVKILTPKDPTYSFYNSDATCRPYTSEGDGCILIRLPEEGRTWSDIDLVVQTEKFLKDNAGQRPEQATLLSEKARENSNREKLLRVQLESLLAEADVWAIGERLPKKSSTPSNIVDEACRYVIENTFGKLKMLRPFNGDISREIHALLTVENDTELDLGNLEESNPDAMREVETWISMNIEYNKPVYLRDILNHFARRPYGWPEDEVKLLVARLACKGKFSFSQQNNNVERKQAWELFNNSRRHSELRLHKVRRHDEAQVRKAAQTMADIAQQPFNEREEPALVEHIRQVFEEWKQELNVFRAKAEGGNNPGKNEIESGLRLLNAILNEKEDFALIEKVSSLKDELLDFSEDREDLVDFYRKQFATWQKLGAALNGSFKSNRSALEKDAAAVKALGELESIWQMPEPYKHLNRITLLIEQVQNVNHQLVEQHRQHALERIDARIEESRQRLLEAHATSELQNSVLLPMQKARKRAEVSQSIPEILAEQQETKALQMDADKKINLWIDELRKKQEAQLRAANEAKRAAESEQTYVVVEKPVIQPVPKKTHLVNVASEMRNATGGEVLETTEQVEKALDTLRTTLLAAIKAGDRIRLQ
What is the function of this protein?
BREX systems (bacteriophage exclusion) provide immunity against bacteriophage.  Part of a type 1 BREX system which protects against dsDNA phage.  This system allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA.  Methylation of bacterial DNA by PglX guides self/non-self discrimination.  When the brxA-brxB-brxC-pglX-pglZ-brxL genes are transformed into a susceptible E. coli strain (BW25113) they confer very high resistance to infection by bacteriophage VR7 and VpaE1, about 100-fold protection against lambda, T5 and T7 and no protection against RNA phage Qbeta, ssDNA phage M13 or dSDNA phage T4 and VR5.  Glycosylated phage DNA is not susceptible to BREX.  The BREX system does not confer resistance to lysogenic lambda phage, i. e.  prophage that are integrated into the chromosomal DNA and then induced to form phage.
What are the official names of this protein?
Probable ATP-binding protein BrxC, BREX protein BrxC.
What is the protein family that this protein belongs to?
Belongs to the BrxC family.
Protein: CENPN_YEAST
Sequence: MSNELRLEDNYVPTSDTLVVFKQLMKLPVTVLYDLTLSWFAKFGGSFDGDIYLLTETLDLLIEKGVRRNVIVNRILYVYWPDGLNVFQLAEIDCHLMISKPEKFKWLPSKALRGDGKPYVVKLQPAKFIENLQTDLAKIYHCHVYMFKHPSLPVLITRIQLFDSNNLFLSTPNIGSINKESLYNKLDKFQGKPLISRRPYYVAFPLNSPIIFHSVDKDIYARLVLQSISRTISERETIIFKPVQKIPVKSIHNIMTLLGPSRFAESMGPWECYASANFERSPLHDYKKHQGLTGKKVMVREFDDSFLNDDENFYGKEEPEIRRLRLEKNMIKFKGSANGVMDQKYNDLKEFNEHVHNIRNGKKNEDSGEPVYISRYSSLVPIEKVGFTLKNEINSRIITIKLKFNGNDIFGGLHELCDKNLINIDKVPGWLAGENGSFSGTIMNGDFQREQVAKGGLL
What is the function of this protein?
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis.  Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
What are the official names of this protein?
Inner kinetochore subunit CHL4, CENP-N homolog, Chromosome loss protein 4, Chromosome transmission fidelity protein 17, Constitutive centromere-associated network protein CHL4, Minichromosome maintenance protein 17.
What is the protein family that this protein belongs to?
Belongs to the CENP-N/CHL4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Protein: CCG3_BOVIN
Sequence: MRMCDRGVQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTHSGLWRTCCLEGAFRGVCKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFHRSRHNVILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRAKSHSELLKKSTFARLPPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKITMGTLLNSDRDHAFLQFHNSTPKEFKESLHNNPANRRTTPV
What is the function of this protein?
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs).  Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization.  Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.  Thought to stabilize the calcium channel in an inactivated (closed) state.
What are the official names of this protein?
Voltage-dependent calcium channel gamma-3 subunit, Neuronal voltage-gated calcium channel gamma-3 subunit, Transmembrane AMPAR regulatory protein gamma-3, TARP gamma-3.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Note=Displays a somatodendritic localization and is excluded from axons in neurons.
Protein: RSMB_ECO24
Sequence: MKKQRNLRSMAAQAVEQVVEQGQSLSNILPPLQQKVSDKDKALLQELCFGVLRTLSQLDWLINKLMARPMTGKQRTVHYLIMVGLYQLLYTRIPPHAALAETVEGAIAIKRPQLKGLINGVLRQFQRQQEELLAEFNASDARYLHPSWLLKRLQKAYPEQWQSIVEANNQRPPMWLRVNRTHHSRDSWLALLDEAGMKGFPHADYPDAVRLETPAPVHALPGFEDGWVTVQDASAQGCMTWLAPQNGEHILDLCAAPGGKTTHILEVAPEAQVVAVDIDEQRLSRVYDNLKRLGMKATVKQGDGRYPSQWCGEQQFDRILLDAPCSATGVIRRHPDIKWLRRDRDIPELAQLQSEILDAIWPHLKSGGTLVYATCSVLPEENSLQIKAFLQRTADAELCETGTPEQPGKQNLPGAEEGDGFFYAKLIKK
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_ONYPE
Sequence: MARQFSLEKTRNIGIIAHIDAGKTTTTERILFHTGKIHKIGETHDGASQMDWMEQEQERGITITSAATTAFWKDHRINIIDTPGHVDFTVEVSRSLRVLDGAVTVIDAQAGVEPQTETVWRQASEYKVPRVIFVNKMDKVGADFAYAIETLKQRLGVHASAIQWPIGSENDFNGIIDLVEMNAFEYDNTSPETGKVVPIPSDLESITQTKRNELIETLSTLDEELMMYYLEEKPISSEMLKNSIRKATLQASFFPVLCGSSFKNKGVVKMLDAIVDYLPAPCDVAAIVGFDSDNQEIVRTGLDEEPFIALAFKVMTDPYVGKLTFFRIYSGSVKAGSYVTNTTKGTKERFGRLLQMHANSREEVKEAYTGDILAVVGLKATTTGDTLASEGQTIVLESMNFPEPVIEIAVEPKTKADQDKMGIALAKLAEEDPTFKVFSNHETGQTIIAGMGELHLDIIIERLKREFKVQANVTEPQVAYRETITQETETEGKFIRQSGGRGQYGHVWMRFEPNPGKGFEFVNKIVGGVVPREYVPAVQKGIQEALAGGILAGYQIIDVKATLFDGSYHDVDSSEMAFKIAASMALKETKTKGNPVILEPIMDVEVVTPNDYVGNVIGDLTSRRGRLENQESRANAVAIRAFVPLSEMFGYATVLRSNTQGRATFIMQFAKYEKAPKSITEEIIKKRA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COF4_DICDI
Sequence: MNSCASINDEVITKYNELILGHISKGIIIKFSDDFKEVVFEDSFNGESFEDYINKFPQDDCRYGVYDFSYMDNKENKKNKIFFISWCPVETKIKNKIVHTATEQSIYKKLVGIDAIIKATDNTEISQSLVEERCK
What is the function of this protein?
Controls actin polymerization and depolymerization.
What are the official names of this protein?
Cofilin-4.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: OPSD_LOLFO
Sequence: MGRDIPDNETWWYNPYMDIHPHWKQFDQVPAAVYYSLGIFIAICGIIGCVGNGVVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFMKYWVFGNAACKVYGLIGGIFGLMSIMTMTMISIDRYNVIGRPMSASKKMSHRKAFIMIIFVWIWSTIWAIGPIFGWGAYTLEGVLCNCSFDYITRDTTTRSNILCMYIFAFMCPIVVIFFCYFNIVMSVSNHEKEMAAMAKRLNAKELRKAQAGANAEMKLAKISIVIVTQFLLSWSPYAVVALLAQFGPIEWVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFRERIASNFPWILTCCQYDEKEIEDDKDAEAEIPAGEQSGGETADAAQMKEMMAMMQKMQAQQQQQPAYPPQGYPPQGYPPPPPQGYPPQGYPPQGYPPQGYPPPPQGPPPQGPPPQAAPPQGVDNQAYQA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Signaling mediates the activation of phospholipase C (By similarity).  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Note=Detected on the rhabdomere membrane in the photoreceptor outer segment.
Protein: PANB_PYRAB
Sequence: MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEILGAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESVLRKVD
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_DINSH
Sequence: MAVPQNKITKSRRGQRRSHDALVAGNPNECPNCGELKRPHHVCAACGHYADREVIAQADEIDLDEDAA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RIMK_STUS1
Sequence: MKIAVLSRNPRLYSTRRLVEAGEQRGHEVVVIDTLRAYMNIASHKPQIHYRGKPLEGFDAVIPRIGASVTFYGCAVLRQFEMQGVFPLNESVAIARSRDKLRALQLLSRRGVGLPVTGFAHSPDDIPDLIRMVNGAPLVIKVLEGTQGIGVVLCETEKAAESVIEAFMGLKQDIMVQEYIKEAGGADIRCFVVGDKVIAAMKRQAKPGEFRSNLHRGGSASLIKITPEERMTAIRAAKVMGLNVAGVDILRSNHGPLVMEVNSSPGLAGIEETTGKDVAGLIIQYLEKNGGPHLTRTKGKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: APT_BIFA0
Sequence: MSQTDIHVANAASMSQDDARYLISLIRTVPDFPREGILFRDFMPVFADSRGLRILLDALIAALPVHTDEFDAVAGLEARGFLFGPALAAQLGKGFIAIRKAGKLPPPVHACSYALEYGKATLEIEDTSVRNNERILIVDDLIATGGSAAAAKDLIESAGGKVAGYEFVMELEGLDGRTALGDYPYGSLLKMPA
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GW2_ORYSI
Sequence: MGNRIGGRRKAGVEERYTRPQGLYEHRDIDQKKLRKLILEAKLAPCYMGADDAAAAADLEECPICFLYYPSLNRSKCCSKGICTECFLQMKPTHTAQPTQCPFCKTPSYAVEYRGVKTKEERSIEQFEEQKVIEAQMRMRQQALQDEEDKMKRKQNRCSSSRTITPTKEVEYRDICSTSFSVPSYRCAEQETECCSSEPSCSAQTSMRPFHSRHNRDDNIDMNIEDMMVMEAIWRSIQEQGSIGNPVCGNFMPVTEPSPRERQPFVPAASLEIPHGGGFSCAVAAMAEHQPPSMDFSYMAGSSAFPVFDMFRRPCNIAGGSMCNLESSPESWSGIAPSCSREVVREEGECSADHWSEGAEAGTSYAGSDIVADAGTMPQLPFAENFAMAPSHFRPESIEEQMMFSMALSLADGHGRTHSQGLAWL
What is the function of this protein?
E3 ubiquitin-protein ligase involved in the regulation of grain size.  May limit grain width and weight by restricting cell proliferation of the spikelet hull.  Possesses E3 ubiquitin-protein ligase activity in vitro.
What are the official names of this protein?
E3 ubiquitin-protein ligase GW2, Protein GRAIN WIDTH AND WEIGHT 2, RING-type E3 ubiquitin transferase GW2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I54A0
Sequence: MNPNQKIITIGSICMAIGIISLILQIGNIISIWVSHSIQTGSQNHTGICNQRIITYENSTWVNQTYVNISNTNVVAGKDTTSMTLAGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPIGEAPCPYNSRFESVAWSASACHDGMGWLTIGISGPDDGAVAVLKYNGIITETIKSWRKQILRTQESECVCVNGSCFTIMTDGPSDGPASYRIFKIEKGKITKSIELDAPNSHYEECSCYPDTGTVMCVCRDNWHGSNRPWVSFNQNLDYQIGYICSGVFGDNPRPKDGKGSCDPVNVDGADGIKGFSYRYGNGVWIGRTKSNSSRKGFEMIWDPNGWTDTDSNFLVKQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPREKTTIWTSGSSISFCGVNSDTVNWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: KDSB_BORPE
Sequence: MSFTVLIPARLASTRLPDKPLADIAGKPMVVRVAERAALSGAERVMIATDDARVQQAAAAHGHAAILTRPDHPTGTDRLSEAVDALGLPDDAIVVNVQGDEPLIEPALIDAVAAQLVAAPHADIATCACPLADAEALFNPNVVKVVCTADRRALYFSRAPIPWARDALAGGARVLAPGLPAWHHIGIYAYRVAFLRRFPALSQGQLERYESLEQLRAMEHGHVIVVHHTDSAPAAGVDTPADLERARAAYTNRL
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA1_PSEPK
Sequence: MQAVDFNSDMGEGFGPWTIGDGVDNELMGYISSANIATGFHAGDPGTMRRTVERAKALGVAVGAHPGFRDLVGFGRRHINASAQELVDDMLYQLGALREIARAQGVRLQHIKPHGALYMHLARDEEAARLLVENLRVIEPELLLYCMPGSVICRIAQELGQPVIREFYADREYDLSGSIVFTRNVRGYEPQAVAERVLRACRQGVVRTVEGQDLAIEFDSICLHSDTPGALDLVEATRKALDAAGIVVRAPR
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A 1, 5-OPase subunit A 1, 5-oxoprolinase (ATP-hydrolyzing) subunit A 1.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: DIPP_ASFK5
Sequence: MQLKTSIGLITCRMNTQSNQIETILVQKRYSLAFSEFIHCHYSINSNHSHLIKMFNNMTINERLLIKTLDFDRMWYHIWIETPVYELYHKKYQKFKKNWLIPDNGKKLISLINQAKGSGTLLWEIPKGKPKENESDLACAIREFEEETGIAREDYQILPAFKKSMSYFEGKTEYKHIYFLAVLCKSLEEPNMNLSLQYETRIAEISKISWQNMEAVRFISKHQSLNLEPIIGPAFNFIKNYLRYKH
What is the function of this protein?
Decapping enzyme required for the removal of the 5'-end m7GpppN cap tethered to viral and host mRNAs to allow their decay in cells.  May therefore accelerate viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins.  Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis.  In addition to the mRNA cap, g5R also efficiently hydrolyzes diphosphoinositol polyphosphates.  Down-regulation of the level of PP-InsP5 (diphosphoinositol pentakisphosphate) may play a role in viral manipulation of the cellular secretory pathway, a step necessary for the formation of virions.  Binds viral and cellular poly(A) mRNAs, thereby decreasing both types of mRNAs.
What are the official names of this protein?
mRNA-decapping protein g5R, g5Rp, ASFV-DP, Diphosphoinositol polyphosphate phosphohydrolase, DIPP.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. DIPP subfamily.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum. Note=Accumulates at the periphery of the viral factories.
Protein: PANC_ECOK1
Sequence: MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSSIADKLQAGERDLDEIIAIAGQELNEKGFRSDDIQIRDADTLLEVSENSKRAVILVAAWLGDARLIDNKLVELA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOC1_ODORO
Sequence: MRLFLSLPVLVVVLAMVLEGPAPAQAAPEISSTLERIPDKLKEFGNTLEDKTRAAIESIKQSDIPAKTRNWFSETFKKVKEQLKTAFS
What is the function of this protein?
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor.  Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL.  Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP).  Binds free fatty acids and reduces their intracellular esterification.  Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
What are the official names of this protein?
Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C1 family.
What are the subcellular locations of this protein?
Secreted.