PharMolix/UniProtQA huggingface dataset:
Protein: RL14_DESOH
Sequence: MIQTETRLKVADNSGAKIVYCIKVLGGSRRRYATVGDVIVVSVKEAIPNSKVKKGDVLKAVIVRTKKEIKRPDGSYIRFDENSAVLISGNNEPLGTRIFGPVARELRAKRFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: TLYA_CAMJJ
Sequence: MRFDFFVSKRLNISRNKALELIENEEVLLNGKSFKASFDVKNFLENLKKTQDLNPEDILLTDGLKLDLLSEIYVSRAALKLKNFLEENGIEIKHKNCLDIGSSTGGFVQILLENQALKITALDVGNNQLHLSLRTNEKIILHENTDLRTFKSEEKFELITCDVSFISLINLLYYIDNLALKEIILLFKPQFEVGKNIKRDKKGVLKDDKAILKARMDFEKACAKLGWLLKNTQKSSIKGKEGNVEYFYYYIKN
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C1920 in 23S rRNA (PubMed:24796671, PubMed:29404277).  Enhances motility (PubMed:24796671, PubMed:29404277, PubMed:32134554).  Enchances biofilm formation (PubMed:29404277, PubMed:32134554).  Involved in the assembly of 70S ribosomes (PubMed:24796671).  Involved in virulence by promoting adherence and invasion to host cells (PubMed:18389311, PubMed:23971210, PubMed:32134554).  Involved in pathogenicity by modulating secretion of host-protective chemokine interleukin 8 (IL-8) (PubMed:32134554).  Involved in susceptibility to antibiotic capreomycin (PubMed:24796671, PubMed:32134554).
What are the official names of this protein?
23S rRNA (cytidine-2'-O)-methyltransferase TlyA, 23S rRNA (cytidine1920-2'-O)-methyltransferase, Hemolysin A.
What is the protein family that this protein belongs to?
Belongs to the TlyA family.
Protein: PSAJ_PSINU
Sequence: MQDVKTYLSTAPVLATLWFGFLAGLLIEINRFFPDALVSPLF
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX, PSI-J.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y342_CHLMU
Sequence: MFASISPYYGVSFFEFFIVFFSRLFSGKLFYDHLYIDDIQVIVFFAIAVSCSIIGTFLVLKKMAMYANVVSHTILFGLVCACLFTHQLTHLSMQNLTIAAISTTLLTGASIHFIRNVFKVAEEASTALVFSLLFSASLLLLVFLTRNAHVGTELVIGNADALAKTDIFPVFLVLLXNLGVSYCFFSSFICVSFDTVFAFSLGIRVKLIDYLMMFLLSASIVGAFKAVGVLMSLAFLLVPGLIAKLIASSVQEMMGYSMIFGVLSALIAPALSRSILSVHGIGLSTSGLAVCLLLVFYIGTLATVFVRRHILLQSKN
What is the function of this protein?
Part of an ATP-driven transport system TC_0338/TC_0339/TC_0341/TC_0342 for a metal.
What are the official names of this protein?
Probable metal transport system membrane protein TC_0342.
What is the protein family that this protein belongs to?
Belongs to the ABC-3 integral membrane protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLYA_NOVAD
Sequence: MTTATAAPEIRKAGFFTEHLETADAEVFAAIRGELKRQQTKIELIASENITSLAVLEATGSVFTNKYAEGYPGKRYYGGCEYADVVENLAIERAKKLFGCNFANVQPNSGSQMNQAVFLALLQPGDSFMGLDLNSGGHLTHGSPVNMSGKWFKPIPYGVRADDHLIDMDEVARLARENKPKLIIAGGTAYSRVWDFKRFREIADEVGAWLLVDMSHFSGLVAGGAHPSPFPHAHVVTSTTHKSLRGPRSGIILTNDEDLAKKFNMAVFPGMQGGPLVHVIAAKAVAFGEALRPEFKAYAAQIVANARALAEAVKDAGLSVVSGGTDNHLMLVDLSAKDVTGKAAEKGLDRAWLTCNKNGVPFDKRSPFVTSGIRLGTPAGTTRGFREEEFRKIGALIGEVVDGLARNGEEGDGQVEQRVRDRVAELCAQFPIYPEL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_RGDV
Sequence: MSGADVESYIFPRIREILTGGISGIREAYINELRVCEKLIQWRNGSDNQVDSTNDASVKGMVFHRVSERNELQNRYAGLYDDLFKLNNNNVDIDVITKHDETIDKIISKELKSKMWYELNDEDIHSSLLPEFQIQTLDDYYDNMKKYLSQDDRDEKGNDNREEEDVKNRNDNVTRIQWQTLMEKDRKVKLHDDLSFSNEVETSLSTYINLRTKEEMDPRYVYHPVPALFITLTLLKVLTGGKAFSYGVRYLEKLCKTISKGERSLATYPAIFGSNGELVATRLYSHYAIKMRLILNNMTYLLTYKSCHEFKDFYIDVNDEVLLYMLENPNGGRDLKKAVTRLNLYYGLRYNPKTTDSLKIIDGVDYHHEHPKYSDRSYDAPIIEPENHFSASEQCYEHNAKLLNQAVYSKTVKEYIDSDIKKVKDLNLPLLTKFTEKLVDMRCNKSIIYDIVFMRTLLNMGGYSRSNQITDFKGTIDDITKMNDEYLSDVSEGGKRAKMSEWMYPKMEACGYGLTKSILNGQMVGVSYPSASESKAHIESYITPNSAGIGNLRFDVDVGGKMYKVRTTSKSAFVNALGTNIFNIDTISMEPMFLSEYLTHLNQDEKMLLYDRRKNRQIQDIELMRLCGQNVIGSRSTTAWRPVRPIYINVIQAHLAQAFIIGPHINATVGRQRTPPKGLWFTGEDVGIGFATIYQNGTSDVISHAIEASASGRCLSVLADCSSWDQTFLTESIIPYYQGIKRAISEFGQADSENYYMYDNQRKDVVGMRLTETIDWFNEYQKKRIFNASYLGERYSFKVQYMWSGRLDTFFMNSVQNALITERIANQVSSSVAGSPSLVWFQVAGDDAIMVYNANSITSSDQVDAIRKTVVDEYTADNHIINPQKTVISHISGEYAKIYYYAGMHFRDPSIQLHESEKISKATNITEVMRGYAQVAFEYNKRAIGSLRINSLYARLLASLAYSINVKRSDDESIENKPNRRGSKAKARSTKTNNLRSFSSVKYYPPLTSVITPTGVKGGLGMSLSGISLNEILMIKELLLDLVEAGLKIVDQVSFEQNEIVSKSLMRHFLRDRKDLIKEMGLDKGTKPVMAVRYRSSDSAFSSGNFENGISMRLESLDSHKLSIARQSEAKLKSVGVNLPKMYTYENLPYSTINQSLKGITIDKDLSRMTNSDLVDQLRSIPESECKGNLISKYPVYGLFNARRIISMDEKVDNPIRYISTPDEGKALERLIGSRTGIQFKNQGYGGSPAIVRFIRRNGLTITEENLIDLVISSGAISLANPKQNMIELFQAISGDQQSSLELANFFMNEKPHWEDKAISITINGSILENCDSRISNISRFVSIDAIRIPGDIKKMFTYIAYVYMCQMFILDENTPSKIHISINEEQLRDFLISAKPISKNRMKQTIDMKFSNQNSGVTIEIDEESLSRTADLDYEVLKLVHPLSVPFLRNLSEGSPM
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with the capping enzyme P5 and protein P7, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase P1, Replicase.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Located inside the inner capsid. Found in the interior of spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RRF_LEGPL
Sequence: MINEIKQDSEKRMKKTIEALHTDMSKIRTGRANASLLDHVMVDYYGSPTPLSQVANITTSDSRTILVTPWEKSMVAAIEKAILNSDLGLNPATAGTAIRVPMPPLTEERRKELIKVVRHEGEQGRVSIRNIRRDANNQLKELVKEKAISEDDERRAAEAIQKLTDRYISEVDAVLAEKEKDLMEI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCC_PSEAE
Sequence: MLEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLSLADESVCIGPAPATQSYLQIPAIIAAAEVTGATAIHPGYGFLAENADFAEQIERSGFTFVGPTAEVIRLMGDKVSAKDAMKRAGVPTVPGSDGPLPEDEETALAIAREVGYPVIIKAAGGGGGRGMRVVYDESELIKSAKLTRTEAGAAFGNPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQKVIEEAPAPGIDEKARQEVFARCVQACIEIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVSEMVTGVDIVKEMLRIASGEKLSIRQEDVVIRGHALECRINAEDPKTFMPSPGKVKHFHAPGGNGVRVDSHLYSGYSVPPNYDSLVGKVITYGADRDEALARMRNALDELIVDGIKTNTELHKDLVRDAAFCKGGVNIHYLEKKLGMDKH
What is the function of this protein?
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
What are the official names of this protein?
Biotin carboxylase, Acetyl-coenzyme A carboxylase biotin carboxylase subunit A.
Protein: Y081_NPVOP
Sequence: MNPNPFLPRKALSPTALNQNLATHRRRPKSKNWTSVNKIKYDSELLLQYLYEGFGADRPYSDINVIKVYKVKVKKTGASILAHYFAHVSTSTGYEFEFHPGSQPRTFQTVHTDGLIIKVHIMCDACCKAELRRYIEGENGFNVAFRNCESILCRRVSFQTLLLGSVILLLLFNVENFSALNLLVILLILLALFCHNNYIISNPHVVFCNHKNALKNHE
What are the official names of this protein?
Uncharacterized 24.9 kDa protein.
Protein: YF3E_SCHPO
Sequence: MDLYDYMAPTTTTEEDDEEGYEKLKEEMGSALNNLTNGKFGLFWNSMKEKSENFLDDTKGKASSGMQQLKSQLEENIPVNSAMENLRKVEETAGSFWSGFGSTVNGFLDQALQISPKEDDVSTPTHEASSSVFLNRHERQLLELVQNENTFTQIISEPSHGITFESWEKEISIDGKTEEISLLLEEYPDLRKQMESLVPSEVSYDDFWKRFFWHKEVVQPIKAIQSGNDEEEIFSWGDERSDEEESDNEQVNDEKKQSSEEDTTENNSAAEVIDETVNDLESAVSKGLQIETQPASHDGEVDGEVKEEEENKVSSSSNIEASQSSLEVKDEANRKVDDDDEDDDDWE
What are the official names of this protein?
BSD domain-containing protein C22A12.14c.
Protein: TRIM5_PYGNE
Sequence: MASGILVNIKEEVTCPICLELLTEPLSLHCGHSFCQACITANHKKSMLYKEGERSCPVCRISYQPENIRPNRHVANIVEKLREVKLSPEEGQKVDHCARHGEKLLLFCQEDRKVICWLCERSQEHRGHHTFLMEEVAQEYHVKLQTALEMLRQKQQEAEKLEADIREEKASWKIQIDCDKTNVLADFEQLREILDWEESNELQNLEKEEEDILKSLTKSETEMVQQTQYMRELISDLEHRLQGSMMELLQGVDGIIKRIENMTLKKPKTFPKNQRRVFRAPDLKGILDMFRELTDVRRYWVDVTLAPNNISHAVIAEDKRQVSSPNPQIMCRARGTLFQSLKNFIYCTGVLGSQSITSGKHYWEVDVSKKSAWILGVCAGFQPDAMYNIEQNENYQPKYGYWVIGLQEGVKYNVFQDGSSHTPFAPFIVPLSVIICPDRVGVFVDYEACTVSFFNITNHGFLIYKFSQCSFSKPVFPYLNPRKCTVPMTLCSPSS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.
Protein: RECX_XANC8
Sequence: MSEQAPAPKRGRRFKEQTPVQRALGLLVRREHSKKELNRKLQARGIEPEAAQAAVERLAGEGWQDDVRFAASVVRNRASSGYGPLHIRAELGTHGLDSDAVSAAMATFEGDWTENALDLIRRRFGEDGPVDLAQRRKAADLLARRGFDGNSIRLATRFDLED
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDS_AQUAE
Sequence: MNVGIFSRWNATCGVSLHAEMIGRELLRRGYPITVFAPYLESASRWWHHKLIRPDEEYVVRCYEELSPDGKEGKIDIEKVLEREIDFLIVESYEKLPYKDVEKLVKILKDKGIPSIAIIHEGDYEDIRYTDMNIFEKVCVFDERYVKEVLKDRVSEEKVEIIPYPCYPVREGSREFAEDGVIKFFSFGRQPKEEYCPYIEGLKVFKRDFPNVKYRIVRAMEPLKIFEDFVEQEERILDYEEIVKELHSADFHLLPKGNTKRVVVSSTLYQVLGTLTLTVVPDNRFFETLPHGEEAPVIFYRDVLELVKELKKASADEEYRKKIRENASKFVEENSVERITDRFENLINSILVKNVH
What is the function of this protein?
Catalyzes the transfer of the mannosyl group from GDP-mannose to di-myo-inositol-1,3'-phosphate (DIP), producing mannosyl-di-myo-inositol phosphate (MDIP) (PubMed:19648237).  Can also use MDIP as an acceptor of a second mannose residue, yielding di-mannosyl-di-myo-inositol phosphate (MMDIP) (By similarity).
What are the official names of this protein?
GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase, MDIP synthase.
What is the protein family that this protein belongs to?
Belongs to the MDIP synthase family.
Protein: PPTA_ECOBW
Sequence: MPHIDIKCFPRELDEQQKAALAADITDVIIRHLNSKDSSISIALQQIQPESWQAIWDAEIAPQMEALIKKPGYSMNA
What are the official names of this protein?
Tautomerase PptA.
What is the protein family that this protein belongs to?
Belongs to the 4-oxalocrotonate tautomerase family. PptA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLUF_SALTY
Sequence: MLTDTSTRLNKYISESGICSRREADRFIEQGNVFINGKRAAIGDQVVAGDIVKVNGRLIEPREADDLVLIALNKPVGIVSTTEDGERDNIVDFVNHSKRIFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPITDEFIRGMGAGVPILGTVTKKCKVKKEAPFVFRITLVQGLNRQIRRMCEYFGYEVTKLERTRIMNVSLSGIPLGEWRDLTDDELIDLFKLIERSSSEAKPKAKAKPKTTGIKRPVVAIEKSNEKARPTSSGKRFTSPGRKKKGR
What is the function of this protein?
Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-2604 in 23S ribosomal RNA and from uracil-35 in the anticodon of tRNA(Tyr).
What are the official names of this protein?
Dual-specificity RNA pseudouridine synthase RluF, 23S rRNA pseudouridine(2604) synthase, Ribosomal large subunit pseudouridine synthase F, rRNA pseudouridylate synthase F, rRNA-uridine isomerase F, tRNA(Tyr) pseudouridine(35) synthase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RsuA family.
Protein: TRKA_ECOL6
Sequence: MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKFDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNMVACQVAYSLFNTPNRIARIRSPDYVRDADKLFHSDAVPIDHLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKAYYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGGGNIGAGLARRLEKDYSVKLIERNQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMSAMLAKRMGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRRGVAEAIEAVAHGDESTSRVVGRVIDEIKLPPGTIIGAVVRGNDVMIANDNLRIEQGDHVIMFLTDKKFITDVERLFQPSPFFL
What is the function of this protein?
Part of the constitutive potassium transport systems TrkG and TrkH.  May regulate the transport activity of TrkG and TrkH systems.  Binds to NAD(+) and NADH (By similarity).
What are the official names of this protein?
Trk system potassium uptake protein TrkA, K(+)-uptake protein TrkA.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripherally bound to the inner side of the inner membrane via the TrkG and TrkH proteins.
Protein: DOHH_CRYNB
Sequence: MSVQVSPEQMATLKATLLNTPGNVPLHERFRALFMLKAVGGDEVVDIVSEGLKDPSPLLKHELAYVLGQLLNTRALPTLSRVLENPTGEHCSMVRHEAAEALGAIGAEESLPILRKYMQDENREVRETCEIAVGKIEFDLSEEGKKANANPDFPTIDPAPSAAPSDIPSLRADLLNTSLPLFQRYRAMFALRDFGAGSKEAVEALADGFRDGSALFRHEIAYIFGQLSSPYSIPSLLSRLRDAKEDDMVRHEAAEALGGIASDGVESENPEVVLPEDERLPEGGVLAVLREWAVKADAPTVVRESCQVAIDMWEYENSADQFNPLDSLSAKQEEREKTEKVNTTGMERSAHAAVAAMGIAA
What is the function of this protein?
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
What are the official names of this protein?
Deoxyhypusine hydroxylase, DOHH, Deoxyhypusine dioxygenase, Deoxyhypusine monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine hydroxylase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DEOD_PASMU
Sequence: MTPHINAPAGAFADVVLMPGDPLRAKYIAETFLQDVKEITNVRNMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITEYGVKKIIRVGSCGAVRMDVKLRDVVIGFGACTDSKVNRIRFKNHDFAAIADFDMTMAAVQAAKAKGLNVHVGNLFSADLFYTPDVEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTPEERQLTFNDMIEIALESVLIGDNA
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: PDRP_CITBB
Sequence: MYHVYLLSDATGETVERVARAALTQFRDVDIRLRRMGQIRNREDILRALDEVDRAPGIIFYTLVNTELAQFVRNEVEARQLEAVDLITPLLYKLAEFLEMRPQKLPGLQYEMNSEYYRRMEAVDFTVKQDDGQEPRNLHKADIVLIGVSRSSKTPLSMYLAHKGYKVANVPIIQGIDPPGELEEVEPERVVGLIIDTQRLVDIRSARLRNLRQSPRGSYADYRQVEEELAYCRRFYRAHPAWLVIDVTNKSVEESAAEILSRLHGDIRHD
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: MUTS_ECO8A
Sequence: MSAIENFDAHTPMMQQYLKLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGDPATSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAELQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESISPNAAATQVDGTQMSLLSVPEETSPAVEALENLDPDSLTPRQALEWIYRLKSLV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: ARGR_EDWI9
Sequence: MRNTTKQEDLIKAFKALLKEEKFSSQGEIVQALQELGFDSINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDVDHNDAIVVIHTSPGAAQLIARLLDSLGKSEGILGTIAGDDTIFTTPAKGFAVEQLYAAILALFEQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_LACLS
Sequence: MTLQEEIKKRRTFAIISHPDAGKTTITEQLLKFGGAIREAGTVKARKTGNFAKSDWMDIEKERGISVTSSVMQFDYAGKRVNILDTPGHEDFSEDTYRTLMAVDAAVMVIDSAKGIEAQTKKLFQVVKRRGIPVFTFINKLDRDGREPLDLLSELEEILGIASVPMNWPIGMGKNFQGLYDFTHGRVEVYQPEDGKRFVEFDENGEVPTSHPLTKNPFFTQALEDAELLLDAGNQFSEDEVVAGQLTPVFFGSALTSFGVETFLETFLEYAPEPHSHKTVDEEEIEPLNPDFSGFIFKIQANMDPRHRDRIAFVRIVSGEFERGMDVNLVRTGKKVKLSNVTQFMAESRENVENAVAGDIIGVYDTGTYQVGDTLTTGKLKKSFEPLPTFTPELFMRVQAKNVMKQKSFQKGIDQLVQEGAIQLYKSYTTGDIMLGAVGQLQFEVFKDRMEREYNSETIMTPMGSKTVRWIKEEDLDEKMSSSRNILARDRFDHPLFLFENEFAMRWFKDKYPDIELMEQFSV
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_DESVM
Sequence: MTIESGRIRIFDTTLRDGEQSPGATMNLQEKIRLARQLETLGVDIMEAGFPASSQGDFEAVQAIARAVKGVEVAGLCRAMPADIDRAWEAVKVAENPRIHTFLATSPVHMQYKLRKEPDQVVEMAVAAVRHAAKYTSNVEFSAEDASRSNPDFLVRVFEAVINAGATTINVPDTVGYAQPEEFGRLIRYVIENTPNSHKAVFSVHCHNDLGMGVANTLAALKAGARQAEVTISGIGERAGNASLEEIVMALHTRRDFYQLDCGVVTEQLFPTCRLLSMIIGQPIPPNKAIVGANAFAHESGIHQDGMLKNRETYEIMTPESIGKTKTDLVIGKHSGRNAVKNKLDELGYRLEEAQLVTVFEAVKKLADKKKQIYDEDIEALVLEEVYRLPDLYRLVNLSVQCSDTGMPPTAAVVMDVMGEVKRAAGFGVGPIDAVFNVIGEIVGRAPVLERYSVTAITGGTDAQGEVTVRLRQNGSSAVGRGSDPDIILASARAYVNALNRLAKKEEEQEKEGI
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: SELA_ESCF3
Sequence: MTTETRSLFSQLPAIDRLLRDSAFLTLRETYGHTRVVDLLRQMVDEAREMIRATQALPAWCDNWACEADARLQKEAQSALRPVINLTGTVLHTNLGRALQAEEAVAAVSQAMRSPVTLEYDLDGAGRGHRDRALAELLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCALHEVGTTNRTHAKDYRQAVNENTALLMKVHTSNYSIEGFTKAVDEAELVSIGKELDIPVVTDLGSGSLVDLSQYGLPKEPMPQELIAAGVSLVSFSGDKLLGGPQAGIIVGKKEMIARLQSHPLKRALRADKMTLAALEATLRLYLHPEALSEKLPTLRLLTRQQEKIQVQGQRLLAPLLAHYGEEFAVAVMPCQSQIGSGSLPVDRLPSAALTFTPHDGRGSRLETLAARWRELPVPVIGRIYDGRLWLDLRCLEDETRFLEMLLK
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSP_MYCBP
Sequence: MSDHSTFADRHIGLDSQAVATMLAVIGVDSLDDLAVKAVPAGILDTLTDTGAAPGLDSLPPAASEAEALAELRALADANTVAVSMIGQGYYDTHTPPVLLRNIIENPAWYTAYTPYQPEISQGRLEALLNFQTLVTDLTGLEIANASMLDEGTAAAEAMTLMHRAARGPVKRVVVDADVFTQTAAVLATRAKPLGIEIVTADLRAGLPDGEFFGAIAQLPGASGRITDWSALVQQAHDRGALVAVGADLLALTLIAPPGEIGADVAFGTTQRFGVPMGFGGPHAGYLAVHAKHARQLPGRLVGVSVDSDGTPAYRLALQTREQHIRRDKATSNICTAQVLLAVLAAMYASYHGAGGLTAIARRVHAHAEAIAGALGDALVHDKYFDTVLARVPGRADEVLARAKANGINLWRVDADHVSVACDEATTDTHVAVVLDAFGVAAAAPAHADIATRTSEFLTHPAFTQYRTETSMMRYLRALADKDIALDRSMIPLGSCTMKLNAAAEMESITWPEFGRQHPFAPASDTAGLRQLVADLQSWLVLITGYDAVSLQPNAGSQGEYAGLLAIHEYHASRGEPHRDICLIPSSAHGTNAASAALAGMRVVVVDCHDNGDVDLDDLRAKVGEHAERLSALMITYPSTHGVYEHDIAEICAAVHDAGGQVYVDGANLNALVGLARPGKFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVRAHLAPFLPGHPFAPELPKGYPVSSAPYGSASILPITWAYIRMMGAEGLRAASLTAITSANYIARRLDEYYPVLYTGENGMVAHECILDLRGITKLTGITVDDVAKRLADYGFHAPTMSFPVAGTLMVEPTESESLAEVDAFCEAMIGIRAEIDKVGAGEWPVDDNPLRGAPHTAQCLLASDWDHPYTREQAAYPLGTAFRPKVWPAVRRIDGAYGDRNLVCSCPPVEAFA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: RL25_BRUME
Sequence: MSETYVLKADLRTRVGKGSSRELRRNGQIPAVIYGDKQEPLAIAVSYKEIFYKIHGGGFKTTVATIEVDGKKIQVLPKDYQLDPVRDFPQHVDFLRVSAKSVVHVNVPVHFKNEEAAPGIKRGGVLNVVRHDVELIVPANAIPEALEIDLSGLEIGDSVHISAVKLPKGATPAIQDRDFTIATIAAPAGLKSEENAEGAAEEAKDGE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.