PharMolix/UniProtQA huggingface dataset:
Protein: LEPA_PECCP
Sequence: MKHIRNFSIIAHIDHGKSTLSDRIIQICGGLTEREMAAQVLDSMDLERERGITIKAQSVTLDYKAQDGQTYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTALDMNLEVVPVLNKIDLPAADPDRVAQEIEDIVGIDATDAVRCSAKTGIGVPDVLDRLVRDIPPPEGSPDEPLQALIIDSWFDNYLGVVSLVRIKNGTMRKGDKIKVMSTGQVYNADRLGIFTPKQIDRDVLNCGEVGWLVCAIKDILGAPVGDTLTLARQPAEKALPGFKKVKPQVYAGLFPISSDDYESFRDALGKLSLNDASLFYEPESSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVETTAKETVYVDSPSKLPPLNNIQELREPIAECHMLLPQEYLGNVITLCIEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYSFKRFQTSDMVRVDVLINNERVDALALITHRDNSQYRGRELVEKMKDLIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDVSRKKKLLQKQKDGKKRMKQVGNVELPQEAFLAILHVGKDSK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PYRC_PHOLL
Sequence: MTTESYTIKIRRPDDWHIHFRDGEMLRTVVPYTSHYFGRAIVMPNLLTPITEVVSAKAYRGRILAAIPEGDNFQPLMTCYLTDTTESSQIEIGYKEGIFTACKLYPANATTNSSHGVSDIKNIYPLLAVMEKLGMPLLVHGEVTASHIDIFDREARFIEQVMEPLRNQFPALKVVFEHITTKEAAQYVLEGNNNLAATLTPQHLMFNRNHMLVGGIRPHLYCLPVLKRNVHQEALRAAVASGCDRFFLGTDSAPHAQQKKESSCGCAGVFNAPSALPAYATVFEEMNALPHFEAFCSLNGPKFYGLPVNEGFIELTRKPSTVIEHIDCNNEKLIPFLAGEDARWDVKVTD
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: COAE_CUTAK
Sequence: MRRTVIGDETTARDVARADWVAGAGGVVRVGLTGGIASGKSTVSQMLGERGAVIIDYDRLSRDVVAVGTQGLAQVVEAFGREVLVADGSLNRSALGSIVFADLQARRRLEAIIHPLVEEAAHRVDEEARAADGLVVVVHDIPLLVETGRADEFDVVMVTDVDPAEQVRRVVERDGCSQADAWARIHAQASREEHLAVADVIIDTSVPLEDLPEQIDRVWSRIAGALRFDRR
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJCH_BACSU
Sequence: MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQDGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFIAHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHVLEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEPFDGDHKWTYWQPLITPALKKML
What are the official names of this protein?
Uncharacterized protein YjcH.
Protein: CTU2_DANRE
Sequence: MCQVEEDYNGLECNQEKIPVSGLNRKCMKCKEGTAVLIIRVSDAFCRSCFKEYFIHKFRAMLGKNRVIFPQEKVLLAVSGGAASCTMLSQVQEGLSRDAPKKLRFMPGIVYIDDGGACGRSEDERQTSISQLKNIFTQTGFPYFIVPLEKVFSLPTSVLVPGTSDPDPSNPCYKQAVDKYLKEKQKLREEEAVCAVAQLNLEDSAYLPEHKLALQRLFSSLKTLSAKQEMLQTLRQHLILHVARENSYSKVMMGESCSRLAVKLLSNIALGRGAALASDTGFSDPRFGDVVIVRPMRDYSSKEITFYNRMFHVPSVFIPGLDTKSHDKASIQRLTESFVTNLQADFPSTVSTIYRTSEKLHTVRPPQSQSTEPEPASKCLLCLCALDTTADKASAFHATLISEQLSQLRLQEGSVDLVAGSSDQCCVEDQTCGTSGCCSSKRTPVQQDLKTLLCYSCRLTVKDMAAVNTLPPYILTEAEKRQRRSQMKVEISEYLLEEDQD
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  May act by forming a heterodimer with ctu1/atpbd3 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 2.
What is the protein family that this protein belongs to?
Belongs to the CTU2/NCS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_SALPA
Sequence: MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMMHVLNNIWRAAEVEKELQRKAQNKENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: PQQC_XANOM
Sequence: MSALLSPDQLEADLRAIGARLYHDQHPFHALLHHGKLDRGQVQAWALNRFEYQRCIPLKDAAILARMEDPTLRRIWRQRIVDHDGNSATDGGIARWLHLTDALGLDRTLVESGRALLPGTRFAVQAYLQFVSEKSLLEAIASSLTELFAPNIIGQRVAGMLKHYDFVSSDALAYFEHRLTEAPRDSDFALDYVKQHADTVEKQALVKAALHFKCSVLWAQLDALHVAYVTPGIVWPDAFVPDRDASRVAA
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: PYRE_SYNS9
Sequence: MPTSPGLTEEQRSDLMRRLATSAYKRGNFTLASGRQSEHYVNCKPVSLSGTGLLLISTAMLSHVEDQSVAVAGLTLGADPLVSGVAVAGSLAHRDLDALIVRKAAKGHGTGAWLEGPLPQPGALITVLEDVVTTGGSSLKAVNQLREAGYVVNRVITIVDREEGGAAAMDAAELELISLFRLSEISAFAAELNQ
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: KPYK_CHLT2
Sequence: MIARTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVESPIKVQPGDRLTLVSKEILGSKESGVTLYPSCVFPYVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSPYLEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGVYPMLTLESNRTVWRHQACVYGVEKGILSNYDKILVFSRGAGMQDTNNLTLTTVHDALSPSLDEIVP
What are the official names of this protein?
Pyruvate kinase, PK.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
Protein: GBS76_DROME
Sequence: MNDPGDIPLTHTSTPDSRPPCSIISIIPTIGMSSCRGRAEAFARSLSSKLRTLGSQTTEEGEGNAEDEPIINGTSTNTWVNSHDSEQTVTDLQPLRHESDSFFDFDCELESPGSPVDECEYLRLIETASNTPHNSTAESGYACASMASSHSSSNDGPYFDASASTSTAAAAQDQTLPASEHKEYVNTLQLNGKHGLANGVQEEQPAFQDDVQEDEAFLQAQILNELQKHSNSLTEVEQTKPEEGKLTNGHLEKVEELELKDVLEVAGTTNRAPKVIAAPQEVEAFADRSQEQSPNDRVQKESSQERVPEGTPFEGVQGESPSDRVQTDASDERVQEEISNDTVQVESNHKSATESISTEVTTLERSPEESRNDELSPDSGVDETDKSASNLTVDVDLAQIEQAKQDATEAVEKSGAPSRGTTVDTTDDEDDCRPQRIRRCSSLKTGKTPPGTPGRKKIVRFADVLGLDLADVKTFLDEIPTIPKSAFEDLEILESEPPLQLGPKSDKLLMPLFQQPGGLPKFLDAVREKQVSLENAAVTDNINQTISGSVRVRNLDFHKSVHIRYSLDGWRSYADLQANYVENSCDGFSDIFTFVLFGNSLHVGQRLEFAVRFQCKGQQFWDNNYGANYCFQCLPSSTHTAGGSTASPPSVATGAVSTGHSASLVGLLSPTAGDAWCSSFY
What are the official names of this protein?
Glycogen-binding subunit 76A, CBM21 domain-containing protein CG9619.
Protein: SL9A5_MOUSE
Sequence: MLSAALLLLPGLPLAGAGATEEPTQESGPLGEPPPGLALFRWQWHEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGVALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNQTLFIIIFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTAVKYTMKTLASCAETVIFMLLGISAVDSSKWAWDSGLVLGTLFFILFFRALGVVLQTWALNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLRVKRSDYHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCGRHFISEDAQERQDKEIFQQNMKRRLESFKSTKHNICFTKSKPRPRKTSHKKKDGVANPEATNGKPPRDLGFQDTAAVILTVESEEEEESDSSETEKEDDEGIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCTQPPTLTRLPPHPLVTEEPQVPIDLSSDPRSSFAFPPSLAKAGRSRSESSADIPQQELQPLMGHKDHTHLSPGTANSHWCIQFNRGGRL
What is the function of this protein?
Plasma membrane Na(+)/H(+) antiporter.  Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry.  Responsible for regulating intracellular pH homeostasis, in particular in neural tissues.  Acts as a negative regulator of dendritic spine growth.  Plays a role in postsynaptic remodeling and signaling.  Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking.
What are the official names of this protein?
Sodium/hydrogen exchanger 5, Na(+)/H(+) exchanger 5, NHE-5, Sodium/hydrogen exchanger, Solute carrier family 9 member 5.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Protein: PRDM6_HUMAN
Sequence: MLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGAGPLKGSGAAGLLSAPQPLQPPPPPPPPERAEPPPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAALAGLSALPVSQLPVFAPLAAAAVAAEPLPPKELCLGATSGPGPVKCGGGGGGGGEGRGAPRFRCSAEELDYYLYGQQRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHGPLHSLRRLVGTSSAAAAAPPPELPEWLRDLPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIPLQCIAQDENLNVPSTVMEAMCRQDALQPFNKSSKLAPTTQQRSVVFPQTPCSRNFSLLDKSGPIESGFNQINVKNQRVLASPTSTSQLHSEFSDWHLWKCGQCFKTFTQRILLQMHVCTQNPDRPYQCGHCSQSFSQPSELRNHVVTHSSDRPFKCGYCGRAFAGATTLNNHIRTHTGEKPFKCERCERSFTQATQLSRHQRMPNECKPITESPESIEVD
What is the function of this protein?
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression.  Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells.  Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation.  It is unclear whether it has histone methyltransferase activity in vivo.  According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a.  According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro.  'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.
What are the official names of this protein?
Putative histone-lysine N-methyltransferase PRDM6, PR domain zinc finger protein 6, PR domain-containing protein 6.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: S35E4_HUMAN
Sequence: MCRCPPEHHDGRMTSAEVGAAAGGAQAAGPPEWPPGSPQALRQPGRARVAMAALVWLLAGASMSSLNKWIFTVHGFGRPLLLSALHMLVAALACHRGARRPMPGGTRCRVLLLSLTFGTSMACGNVGLRAVPLDLAQLVTTTTPLFTLALSALLLGRRHHPLQLAAMGPLCLGAACSLAGEFRTPPTGCGFLLAATCLRGLKSVQQSALLQEERLDAVTLLYATSLPSFCLLAGAALVLEAGVAPPPTAGDSRLWACILLSCLLSVLYNLASFSLLALTSALTVHVLGNLTVVGNLILSRLLFGSRLSALSYVGIALTLSGMFLYHNCEFVASWAARRGLWRRDQPSKGL
What is the function of this protein?
Putative transporter.
What are the official names of this protein?
Solute carrier family 35 member E4.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35E subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYT_PARP8
Sequence: MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKIDGELVDTSALIDHDVALAIVTDKDADGLDIIRHSTAHLLAYAVKDLFPEAQVTIGPVIDNGFYYDFSYSRPFTPEDLEKIEKRMQELAKKDEPVSRRVVSRDEAADYFKSIGEKYKAEIIESIPASDDIKLYSHGGFTDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTKKEDQDAYLHMLEEAEKRDHRKLGKQLDLFHMQDESPGMVFWHPRGWTLWQQVEQYMRRRVNEAGYLEIKTPMIMDRSLWEASGHWQNYRDNMFTTESEKRDYAIKPMNCPGHVQVFNHGLRSYRDLPLRYAEFGSCHRNESSGALHGLMRVRGFVQDDAHIFCTEDQFISESIAFNTLAMSVYKDFGFDNVEIKLSLRPDARAGTDEIWDRAEQGLRDALTACGVTWEELPGEGAFYGPKVEYHIKDALGRSWQCGTLQLDMVLPERLGAEFVAEDNSRRRPIMLHRAIVGSMERFLGILIEHHAGAMPAWLAPMQVVVMNIAESQAEYAQSLAQSLQKQGVRVEADLRNEKISYKIREHTLEKVPYLLVVGDKERDAQTVAVRARGGIDLGVMPVDAFSERLRQDVQTFN
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_ERWT9
Sequence: MALQQDIIEALGVKPTIDADEEIRISVDFLKSYLKRYPFLKSLVLGISGGQDSTLTGKLCQMAMTELRAESGDSDYQFIAVRLPHGVQADEQDCQDAITFIQPDRVLTVNIKAAVQASEQALREAGITLSDFIRGNEKARERMKVQYSIAGMNAGVVVGTDHAAEAVTGFFTKYGDGGTDINPIFRLNKGQGKRLLNALGCPEHLWLKHPTADLEDDRPGLQDEVALGVTYEMIDRYLQGESIDPAAAKIIEGWYVKTEHKRRTPITVFDDFWKK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: DAPB_ACICJ
Sequence: MNGADLRIGIAGITGRMGKLLAEAVPLAGATLAGGIGRDGDLAALARESDVVIDFTVAATVSRHAGILAAAGTPWVLGTTGFDPAAEADIADAAARIPVFQAANFAPGVNLVIALAERLGATLAAETHDAEILEMHHRQKIDAPSGTALAIGAAVARGRGVDLAAVKDSGRDGHTGKRETGAIGFAALRGGQIVGSHSAIFTSAVEQITLTHHALDRRIFAEGAVRAALWLAGRAPGRYGMRDLLGL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRL7L_ARATH
Sequence: MILPFSTQFTCPVQDNGFSPSSLLSHCKRDRFEVTSLRYDSFGSVKTASSSKWNVMRSRRNVKAFGLVDKLGKKVWRKKEEDSDSEDEEDEVKEETFGGKEASLDDPVERREWRKTIREVIDKHPDIEEDEEIDMVEKRRKMQKLLADYPLVVNEEDPNWPEDADGWGFSFNQFFNKITIKNEKKEEEDDDEDSEGDDSEKEIVWQDDNYIRPIKDLTTAEWEEAVFKDISPLMVLVHNRYKRPKENEKFREELEKAIQVIWNCGLPSPRCVAVDAVVETDLVSALKVSVFPEIIFTKAGKILYREKGIRTADELSKIMAFFYYGAAKPPCLNGVVNSQEQIPLVDVSVN
What is the function of this protein?
Plays an essential role in early steps of chloroplast development (PubMed:21515910, PubMed:24111559).  Involved in the regulation of plastid gene expression (PubMed:21515910, PubMed:24111559).  Required for the proper function of the plastid transcriptional machinery and protein accumulation in thylakoid membranes (PubMed:21515910, PubMed:24111559).  May function as molecular chaperone to ensure proper organization of the nucleoids in chloroplasts (PubMed:21515910, PubMed:24111559).  Is a necessary component of phytochrome signaling for photosynthesis-associated plastid-encoded genes (PhAPGs) activation (PubMed:31201314).  Mediates the degradation of two repressors of chloroplast biogenesis, PIF1 and PIF3 in nucleus (PubMed:31201314).  Promotes the assembly of the plastid-encoded RNA polymerase (PEP) complex for PhAPG transcription in plastids (PubMed:31201314).
What are the official names of this protein?
Thioredoxin-like fold domain-containing protein MRL7L, chloroplastic, Protein MESOPHYLL-CELL RNAI LIBRARY LINE 7-LIKE, AtMRL7-L, Protein NUCLEAR CONTROL OF PEP ACTIVITY, Protein SUPPRESSOR OF VARIEGATION 4-LIKE.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Nucleus.
Protein: RS4_STRR6
Sequence: MSRYTGPSWKQARRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFTYGVGEKQFRNLFVQATKIKGGILGFNFMLLLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSYRVTPGQVISVREKSLKVPAILEAVEATLGRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RS4_ENCCU
Sequence: MPTGHRDHLKRKTAPKSWMLDKQGGTFALMPASGPHKKTECIPLGYLISRFLRYASNFKELSIILAEKNIKVNGRVRTNSHFPVGLFDVVSIEKTGEHFRVLYNVHKKFHLHRISSEEASYRLTKVTKKYENQGIPYIVSSCGLSIRFCDPAIDLGYTIKISNETSKVIEYIVPGPDKVIFVSRGKARGRVGVINTISTQGKETVYGMTDFAGNTFSCTSKSCILIGESSENIWITLPKERGIRQSELEKINAQLGEMIDTEVAEVSE
What are the official names of this protein?
40S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y095_MYCGE
Sequence: MKLKFYKLPLITTAFSFVFLTACSTPQSSFFLPAQTTISTLKINGMENKTGYFLETQRSRGSYNPTASLTMIKLGDEKEFKNVDTTKQDEVLFANIYGGISSLLNFRIIQPMLTYWNLVNNSLSQIGSTNDLITFKDSGYKDQLAKALANNLIVADEGNNNFWFGLKALKFDTVKLQANNTATSSTRASTTQNTNNKIDAREKITINGNGGTNNDQNATVQKLIGIENIEVEFSFVKTGFNGNEIKFEDYVTDSSPTTSLLKQVWKSKWNTELTHTSFKFKLNSFNVLLTYQLEANQKSQYLPNGFSFLFPSNLEGKIDSSKSYWNNLVDFSKRTTNEENTMLLTDLQKKQDQVNRFVGFIGQNHFTLSANSINEKQFNDASTADFFKAIFQKVSINE
What are the official names of this protein?
Uncharacterized lipoprotein MG095.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: YG3Z_YEAST
Sequence: MHRLRAYCVISALSDTLLAFCTSSAELYEGPLRQYRIKATQIRRWFGRRACRTIPIRHDPVECPEPRSCPCSYHSRLWSKRLGRTQISRRLQTARRLNPERSTAWSYLARQVLYY
What are the official names of this protein?
Putative uncharacterized protein YGR176W.
Protein: THIG_BIFLO
Sequence: MEDKPLNLGGHEFQSRFILGSGRYDLNLIKATVEHAGTQIVTMALRRAQTTENSVLDYIPEGITLLPNTSGARNAEEAVRIARLAREVCHTDFVKVEIEHETKYLLPDNAETIRATEMLAKEGFVVMPYMFPDPIAARQLEEAGAAAVMPLGSLIGSNMGLRMRDFIEIIIANAHVPVIIDAGIGRPSQACDAMEMGADAVMAYTAVASAGNIPLMAEAFKHAIDAGRAAYLSGLGKVTEGQAVPSSPTTGYLH
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_STRAW
Sequence: MSVTVRVPAKVNVQLAVGGARPDGFHDLANVFLAVGLYDEVTATPADELRITCEGPDAAQVPLDRTNLAARAAIALAARHGLAPDVHLHIAKDIPVAGGMAGGSADAAGALLACDTLWGTNASRGELLDICAELGSDVPFSLVGGAALGTGRGERLRELEVGGTFHWVFAVADGGLSTPAVYGEFDRLSEGVRVPEPVASQELLDALAKGDAVALAAAVSNDLQPAALSLFPSLSDTLEAGRAAGALAALVSGSGPTTAFLTRDADGADAVAQALLASGTCRTARVAPSPAPGATVL
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RSMJ_PSEFS
Sequence: MSEQPAASRIQVEALGDGFKARAEQWASLLGLPLQLADADFSLQVGEHGLQLQQLGPDAPGPVRVDFVEGGAAHRRLYGGGSGQMIAKAVGIAQGVRPRVLDATAGLGKDAFVLASLGCEMSLIERQPLIGALLEDGLARGADDFEVAPIVARMQLLKGNSIDVMRNWEGEPPQVIYLDPMFPHREKTALVKKEMRLFRPLVGDDPDAPALLAAALALASHRVVVKRPRKAPCIDGPKPSHALDGKSSRYDIYPKKALKP
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CABP_SCHMA
Sequence: MVNRTEAAQLLKHLDRDKSGKISSQELMEFLHTVNCPFKKEQVEKFIKQHDKDGDGQLNTDELLDVLCS
What are the official names of this protein?
Calcium-binding protein, CaBP.
Protein: MPAG2_PENBR
Sequence: MSAASPASIIQELASAAKQYENNESGAREALIAQSRALIASLEVPSEFIQHTFWSQPALSAIVRLATDVNLFQYLKDAQEEGLNAEALASKTGMDVSLFARLARHLVAMNVITSRNGVFYGTALSNGLAAENYQQSIRFCHDVSRPSFGAFPSFFKGNGYKTPALGTTDGPFQSAHKVDISFPQWLVGNPPYLQYFNSYMSAYRAGKPNWCDNGFYPVADRLLNGFDASVSDVLLVDVGGGRGHDIATFGSQFSPLPGRLVLQDREQVINSIPADESRQFEATTHDIFTTQPVKHARAYYMHSVPHGFGDEDAVKIMANLVPALAKGYSRVLLNEIVVDEERPVMSATNMDLIMLAHMGAKERTEADWRSILTRAGLKVVNIYSYPGVAESLIEAELA
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (PubMed:25630520, PubMed:31209052).  MpaG' methylates farnesyl-DHMP-3C (FDHMP-3C) to yield MFDHMP-3C (PubMed:25630520, PubMed:31209052).  The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC.  5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE.  MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB).  MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP.  The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP).  The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate.  The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C.  After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight.  Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps.  The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process.  Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (PubMed:31209052) (Probable).
What are the official names of this protein?
O-methyltransferase mpaG', Mycophenolic acid biosynthesis cluster protein G'.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.