PharMolix/UniProtQA huggingface dataset:
Protein: DOPD_MOUSE
Sequence: MPFVELETNLPASRIPAGLENRLCAATATILDKPEDRVSVTIRPGMTLLMNKSTEPCAHLLVSSIGVVGTAEQNRTHSASFFKFLTEELSLDQDRIVIRFFPLEAWQIGKKGTVMTFL
What is the function of this protein?
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
What are the official names of this protein?
D-dopachrome decarboxylase, D-dopachrome tautomerase.
What is the protein family that this protein belongs to?
Belongs to the MIF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_CHLP8
Sequence: MNITSADFFCSYSSLNGLPSDGRPEIVFVGRSNVGKSSLLNSLCARKGLAKTSSTPGKTRLINYFLINENLYFVDLPGYGYAKVGHGERESWGKLLTDYVVKRDEIALVVLLVDARHPGMGSDREMMEFLDYCGRPFGIVLTKWDKLKQAEKSKARRTIESCASNARFIVNYSSLSGAGRDKLLERLDLFSQ
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: GPDA_BRUO2
Sequence: MSTKIAVLGGGAWGTALAAMAAKGGHESWLYARDAETVVAINKDRRNPCYLGDITLADGIRASTDAAAVVTGADAVLAVIPAQAMRNGLSELGTLIPQASPIVLCAKGIEQNTGRLMSEVVAEILPDHRIAALSGPSFASDVARGLPTAVTVACEDANTADRLAALLSGPAFRCYSTTDLKGVETGGALKNVLAIAAGAAIGRGYGASAQAALVTRGFAELRRIGQAMSARPETIMGLSGLGDLMLTCSSSQSRNYSYGLALGRGEDLTSRPLAEGVATAPIAAELCRKHNISAPIIDAVGALLDGKITIDEAVTALLNRPLKTED
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TV23A_HUMAN
Sequence: MKQALVDDTEDVSLDFGNEEELAFRKAKIRHPLATFFHLFFRVSAIVTYVSCDWFSKSFVGCFVMVLLLLSLDFWSVKNVTGRLLVGLRWWNQIDEDGKSHWIFEARKVSPNSIAATEAEARIFWLGLIICPMIWIVFFFSTLFSLKLKWLALVVAGISLQAANLYGYILCKMGGNSDIGKVTASFLSQTVFQTACPGDFQKPGLEGLEIHQH
What are the official names of this protein?
Golgi apparatus membrane protein TVP23 homolog A.
What is the protein family that this protein belongs to?
Belongs to the TVP23 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FETP_PSEF5
Sequence: MTRTVMCRKYQEELPGLERPPYPGAKGQDIFDHVSAKAWADWQKHQTLLINEKRLNMMNADDRKYLQGEMDKFFSGEEYAKADGYVPPAE
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: ARAB_ECOLI
Sequence: MAIAIGLDFGSDSVRALAVDCATGEEIATSVEWYPRWQKGQFCDAPNNQFRHHPRDYIESMEAALKTVLAELSVEQRAAVVGIGVDSTGSTPAPIDADGNVLALRPEFAENPNAMFVLWKDHTAVEEAEEITRLCHAPGNVDYSRYIGGIYSSEWFWAKILHVTRQDSAVAQSAASWIELCDWVPALLSGTTRPQDIRRGRCSAGHKSLWHESWGGLPPASFFDELDPILNRHLPSPLFTDTWTADIPVGTLCPEWAQRLGLPESVVISGGAFDCHMGAVGAGAQPNALVKVIGTSTCDILIADKQSVGERAVKGICGQVDGSVVPGFIGLEAGQSAFGDIYAWFGRVLGWPLEQLAAQHPELKTQINASQKQLLPALTEAWAKNPSLDHLPVVLDWFNGRRTPNANQRLKGVITDLNLATDAPLLFGGLIAATAFGARAIMECFTDQGIAVNNVMALGGIARKNQVIMQACCDVLNRPLQIVASDQCCALGAAIFAAVAAKVHADIPSAQQKMASAVEKTLQPCSEQAQRFEQLYRRYQQWAMSAEQHYLPTSAPAQAAQAVATL
What are the official names of this protein?
Ribulokinase.
What is the protein family that this protein belongs to?
Belongs to the ribulokinase family.
Protein: HRCA_BRUSI
Sequence: MMRPPEHQLLSSLDQRSRDIFRLIVETYLNDGDPVGSRNLSRLLPHTLSPATIRNVMSDLEHLGLIYAPHISAGRLPTQIGLRFFVDAFLEVGDLPPEERSSIEAQVRAAGTSNSVESVLTEASQVLSGLSRGAGLVLTNKTDVALKHIEFVRLEPMRALAVLVMQNGDVENRVIDLPAGISTSQLIEASNFLNAHIHGHTLSEAKSELRKLSEETRRELDQLSQELVAKGLAVWSGAGADQPARLIVRGRANLLENVHAQEDIERLRHLFDDLETKDGMVQLLDLAEAGSGVRIFIGSENKLFSLSGSSLVVAPYRDSEQRVIGALGVIGPTRLNYARIVPMVDYTAQIVSRLLR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: SODL_VACCW
Sequence: MAVCIIDHDNIRGVIYFEPVHGKDKVLGSVIGLKSGTYSLIIHRYGDISQGCDSIGSPEIFIGNIFVNRYGVAYVYLDTDVNISTIIGKALSISKNDQRLACGVIGISYINEKIIHFLTINENGV
What is the function of this protein?
Superoxide dismutase-like protein with no enzymatic activity.
What are the official names of this protein?
Cu-Zn superoxide dismutase-like protein OPG175.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Accumulates predominantly in cytoplasmic viral factories.
Protein: CSLF3_ORYSI
Sequence: MASPASVAGGGEDSNGCSSLIDPLLVSRTSSIGGAERKAAGGGGGGAKGKHWAAADKGERRAAKECGGEDGRRPLLFRSYRVKGSLLHPYRALIFARLIAVLLFFGWRIRHNNSDIMWFWTMSVAGDVWFGFSWLLNQLPKFNPVKTIPDLTALRQYCDLADGSYRLPGIDVFVTTADPIDEPVLYTMNCVLSILAADYPVDRSACYLSDDSGALILYEALVETAKFATLWVPFCRKHCIEPRSPESYFELEAPSYTGSAQEEFKNDSRIVHLEYDEFKVRLEALPETIRKRSDVYNSMKTDQGAPNATWMANGTQWPGTWIEPIENHRKGHHAGIVKVVLDHPIRGHNLSLKDSTGNNLNFNATDVRIPMLVYVSRGKNPNYDHNKKAGALNAQLRASALLSNAQFIINFDCDHYINNSQALRAAICFMLDQREGDNTAFVQFPQRFDNVDPKDRYGNHNRVFFDGTMLALNGLQGPSYLGTGCMFRRLALYGIDPPHWRQDNITPESSKFGNSILLLESVLEALNQDRFATPSPVNDIFVNELEMVVSASFDKETDWGKGVGYIYDIATEDIVTGFRIHGQGWRSMYCTMEHDAFCGTAPINLTERLHQIVRWSGGSLEMFFSHNNPLIGGRRLQPLQRVSYLNMTIYPVTSLFILLYAISPVMWLIPDEVYIQRPFTRYVVYLLMIILMIHMIGWLEIKWAGITWLDYWRNEQFFMIGSTSAYPTAVLHMVVNLLTKKGIHFRVTSKQTTADTNDKFADLYEMRWVPMLIPTMVVLVANIGAIGVAIGKMAVYMGVWTIAQKRHAIMGLLFNMWVMFLLYPFALAIMGRWAKRPIILVVLLPIIFVIVALVYVATHILLANIIPF
What is the function of this protein?
May catalyze both beta-1,3 and beta-1,4 glycosidic linkage on beta-D-glucan.  Essential for (1,3;1,4)-beta-D-glucans synthesis in grasses and cereals (Poaceae).  The mixed-linked glucans (which are not present in walls of dicotyledons or most other monocotyledonous plants) are particularly important constituents of the walls of the starchy endosperm and aleurone cells of cereal grains such as oats, wheat, rice and barley.  They can account for up to 70% by weight of the wall (By similarity).
What are the official names of this protein?
Probable mixed-linked glucan synthase 3, 1,3;1,4-beta-D-glucan synthase 3, Cellulose synthase-like protein F3, OsCslF3.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like F subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: THIE_SALDC
Sequence: MYQPDFPTVPFRLGLYPVVDSVAWIERLLEAGVRTIQLRIKDKRDEEVEADVIAAIALGRRYNARLFINDYWRLAIKHRAYGVHLGQEDLETTDLKAIQAAGLRLGVSTHDDMEIDVALAAKPSYIALGHVFPTQTKQMPSAPQGLAQLASHIERLADYPTVAIGGISLERATAVLATGVGSIAVVSAITQAADWRAATAQLLDIAGVGDE
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: Y2417_NATTJ
Sequence: MPRPPRKRTVEFVPEINYFKPAGVPLRELQEEVLNVDELEAVRLKDIEGLDQQDAAKKMNVSRSTFQLILTNAREKISKALVSGKAIRIEGGIYQVRDCQCGCEQHRHRGGPKSS
What are the official names of this protein?
UPF0251 protein Nther_2417.
What is the protein family that this protein belongs to?
Belongs to the UPF0251 family.
Protein: CYH1_HUMAN
Sequence: MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
What is the function of this protein?
Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6.  Promotes the activation of ARF factors through replacement of GDP with GTP.  Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.
What are the official names of this protein?
Cytohesin-1, PH, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog B2-1.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol. Cell junction, tight junction. Cell junction, adherens junction. Note=Colocalized with TJP1 during epithelial polarization.
Protein: CRP_HAEIN
Sequence: MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLGAGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQTLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR
What is the function of this protein?
A global transcription regulator required for bacterial competence.  Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to regulate transcription at 54 promoters (PubMed:15769466).  There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression.  CRP-S sites bind DNA but do not activate transcription in the absence of Sxy.  Probably induces a severe bend in DNA.  Probably acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.
What are the official names of this protein?
cAMP-activated global transcriptional regulator CRP, Catabolite activator protein, CAP, cAMP receptor protein, CRP, cAMP regulatory protein.
Protein: VIAA_SALPB
Sequence: MLTLDTLNTMLAVSEEGMVEEMILALLASPQLVIFFEKFPRLKNAVTADLPRWREALRSRLKDARVPPELTEEVMCYQQSQLLSTPQFIVQLPQILALLHRLHSPYAAQAKQLTESNSTFTPALHTLFLQRWRLSLVVQATTLNQQLLEEEREQLLSDVQERMTLSGQLEPTLAENDNAAGRLWDMSAGQLKRGDYQLIVKYGEFLAAQPELMQLAEQLGRSREAKSVPKKDAPMETFRTLVREPATVPEQVDGIQQGDDILRLLPPELATLGITELEYEFYRRLVEKQLLTYRLHGEAWREKVTERPVVHQDVDEQPRGPFIVCVDTSGSMGGFNEQCAKAFCLALMRVALADNRRCFIMLFSTDVVRYELSGPEGIEQAIRFLSQRFRGGTDIASCFRAIIERMQGREWFDADAVVISDFIAQRLPDDVVSKVGELQRLHQHRFHAVAMSAHGKPGIMRIFDHIWRFDTGMRSRLLRRWRR
What are the official names of this protein?
Protein ViaA, VWA domain protein interacting with AAA ATPase.
What is the protein family that this protein belongs to?
Belongs to the ViaA family.
Protein: LIPB_RHOPA
Sequence: MINISTSPRQTLDWTALKPADGSPAVEWRISDSPVPYPEAVATMEARAAAIAAGEATELVWLLEHPPLYTAGTSGHASDLLEERFPLFTTGRGGQLTYHGPGQRVAYVMLDLKRRRPDVRAYVAALEQWIIATLDAFNIRGERREDRVGVWVRRPDKGVGYEDKIAAIGVRLKRWVSLHGIAINVEPDLSHFKAIVPCGISDPRYGVTSLVDLGLPVVMTDVDIALRAAFENIFGETRAAAPAGI
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WTX1A_NEOGO
Sequence: WLGSALKIGAKLLPSVVGLFKKKKQ
What is the function of this protein?
Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S. cerevisiae.  Has insecticidal and hemolytic activities.
What are the official names of this protein?
M-poneritoxin-Ng1a, M-PONTX-Ng1a, Poneratoxin, Ponericin-W1.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Medium-length antimicrobial peptide (group 3) family. Ponericin-W subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MURD_PETMO
Sequence: MKICLVGYGKSNNELLTKLLKSNHEIFVSQDKDFTKTDEIYFKKNNIQYETNHNDLLKNCDLAIVSPGIPPNSKAAKIIFENNIDYTTELEYSWQNIKKENKKAVFIGITGTDGKSTTTSLIGHILKFADPLTFVGGNIGVPLAKASETLNYYVVEVSSFQIFWSKTFTPEISVLTNLAPDHLNWHKDLNDYYQTKAKLLLRTLKSGGVAVVNEDAVNLLNLKDYQASERIITFSKNMIEGNYIKYKDKKIQVNNKIFELDIFKEDILASAVTTLNLGISEKIIEEAINSFKPLKYRLELIKSKNGVNYYNDSKATNVHSAYNAYKSFRGMHYIAILSGIPKNEDLTPLIEELKTYAKAVIVFGEMEKEVKKYPLNSKFIFKNNLEEVFLYLSEICEVGDNVVFSPAGASFDKYKNYEERGEHFNLLVEKS
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHOB_SHIDY
Sequence: MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRDIPVVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIEMQGLSLDPTSHRVMTGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTGYRFSTRF
What is the function of this protein?
This protein is a positive regulator for the phosphate regulon.  Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.
What are the official names of this protein?
Phosphate regulon transcriptional regulatory protein PhoB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDIB_ECOK1
Sequence: MDVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPFTYMAFEVDNDSFPAAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIKGKTMVLLGAGGASTAIGAQGAIEGLKEIKLFNRRDEFFDKALAFAQRVNENTDCVVTVTDLADQQAFAEALASADILTNGTKVGMKPLENESLVNDISLLHPGLLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFTLWTGKDFPLEYVKQVMGFGA
What is the function of this protein?
The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate.  Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively.  It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.
What are the official names of this protein?
Quinate/shikimate dehydrogenase, NAD-dependent shikimate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: MURE_PSEPK
Sequence: MMTMPLSKLFAHASRDPLIRELTLDSRSVRPGDLFLAVPGAKVDGREHIADALARGAAAVAYEEQGANVLPLTDVPLIPVKGLIAQLSDIAGRFYGEPSRQLNLVGVTGTNGKTSVTQLVAQALDLLGQRCGLIGTLGTGFYGELQSGRLTTPDPIAVQSTLNDLKKGGARAVAMEVSSHALEQGRVAALEFDIAVMTNLSRDHLDYHGSMEAYEAAKAKLFAWPSLRCQVVNLDDDFGRRLAADFARRPSVDHIETRLLSYSLESPEASLFCREAVFSDDGVRATLVTAQGERILRSQLLGRFNLSNMLAAVATLLALDYALDEILKVTPQLQGPVGRMQRLGGGDKPLVVVDYAHTPDALEKVLEALRPHAHGKLLCLFGCGGDRDRGKRPLMAEVAERLADRVLVTDDNPRTEDPSRIFDDIRPGFTRPDDVEFVAGRGEAIAHLIATAAANDVIVLAGKGHEDYQEINGERHDFSDLTEAEKALAAWEAPHA
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPCE_AERHY
Sequence: MSGKARLHYPVTRQSEQLDHYFGQAVADPYRWLEDDRSPETEAWVKAQNRVTQDYLAQIPFRDAIKGKLATSWNYAKEGAPFREGRYHYFFKNDGLQNQNVLCGQLAGKPAEVFLDPNLLSPDGTTALDQLSFSRDGKTLAYSLSLAGSDWREIHLMDVESKQPLETPLRDVKFSGISWLGNEGFFYSSYDKPDGSELSARTDQHKLYFHRLGTAQEEDRLVFGAIPAQRHRYVGATVTEDDRYLLISAADSTSGNRLYVKDLTREGAPLLTVQGDLAADVSLVDNKGSRLYLLTNRDAPNRRLVTVEADNPGPEQWRDLIPERQQVLTVHSGGGYLFAEYMVDATARVEQFDHDGKRVREVGLPGLGSVSGFNGKQDDPALYFGFENYAQPPTLYKFEPNSGAISLYRASAAPFKPEDYVSEQRFYRSKDGTRVPLIISYRKGLKLDGSNPTILYGYGGFDVSLTPSFSVSVANWLDLGGVYAVANLRGGGEYGQAWHLAGTRMNKQNVFDDFIAAAEYLKAEGYTRTDRLAIRGGSNGGLLVGAVMTQRPDLMRVACQAVGVLDMLRYHTFTAGAGWAYDYGTSADSEAMFDYLKGYSPLHSVRAGVSYPSTLVTTADHDDRVVPAHSFKFAATLQADDAGPHPQLIRIETNAGHGAGTPVAKLIEQSADIYAFTLFEMGYRQLPRQP
What is the function of this protein?
Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.  Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond.
What are the official names of this protein?
Prolyl endopeptidase, PE, Post-proline cleaving enzyme.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9A family.
Protein: ZIC1_XENLA
Sequence: MLLDAGAQYPAIGVTTFGSSRHHSAGDVTDREVALGINPFADGMGAFKLNPSSHDLASGQTAFTSQAPGYAAAALGHHHHPGHVSSYSSAAFNSTRDFLFRNRGFGEAASAQHSLFASAAGGFPGPHGPHADTTGHLIFPGLHEQAASHASPNVVNGQMRLGFSGDMYGRPDQYGQVTSPRSEHYASSQLHGYGPMNMNMAAHHGAGAFFRYMRQPIKQELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICVWEECPREGKPFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHEASSQGSQPSPAASSGYESSTPPTIVSPSAENQSTSSLSPSSSAVHHTSNHSTLSSNFNEWYV
What is the function of this protein?
Transcriptional activator that induces expression of multiple genes including pax3, en2, snai2/slug, feb and a subset of wnt genes.  Has multiple key roles in the regulation of neural induction and neurogenesis: acts as a neural competence factor, sensitizing the presumptive neuroectoderm to respond to subsequent neuralizing signals.  Promotes both preplacodal cell fates and neural crest cell fates, two of the cell populations that arise from the neural plate border.  Cooperates with pax3 in concert with wnt signaling to determine neural crest fate.  Synergizes with the bmp-inhibitor noggin/nog and acts through the wnt pathway to induce expression of en2.  May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
What are the official names of this protein?
Zinc finger protein ZIC 1, XZic1, XlZic1, ODD-paired-like, Xopl, ZIC-related protein 1, ZIC-r1, Zinc finger protein of the cerebellum 1.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: PCKA_SELRU
Sequence: MANIDLSQYGITGTTGILHNPSYKTLFEEETKEGLTGYEQGQVSELGAVNVKTGIFTGRSPKDKFIVDDETSHDTVWWDSEDYHNDNHRATPETWNALKEIAKKELSNKKLYVVDAFCGANKDTRMAVRFIVEVAWQAHFVTNMFIQPTEEELANFKPDFVVYNASKAKVENYKELGLHSETAVVFNLTSREQVIINTWYGGEMKKGMFSMMNYFLPLKGIAAMHCSANTDKQGQNTAIFFGLSGTGKTTLSTDPKRLLIGDDEHGWDDEGVFNFEGGCYAKVINLDMESEPDIYGAIKRNALLENVTLDDKGNIDFADKTITENTRVSYPIDHIKGTVKGFVNDKSAAPAAKSVIFLSADAFGVLPPVSILTPEQTKYYFLSGFTAKLAGTERGITEPTPTFSACFGQAFLELHPTKYAEELVKKMEANGTKAYLVNTGWNGSGKRISIKDTRGIIDAIHSGAIKKAPTKKIPFFNLEVPTELEGVDTNILDPKDTYANPADWEAKAKDLAQRFIKNFDKYTKNNEAGKALVAAGPQL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCFA_DICDI
Sequence: MVINNQNNNNQNNNQNNNNKNDNLNNSTTTTTTTATTTKSSTLFHSNDFFSGLIAGIVSRTLTAPLERIKILNQVEVILKDGTKYNRIIPAFKVIIKEEGIAGLFRGNFVNIIKAGPQSAIRFYSYGAFKRMASEPDGSISVINRMWAGASSGVVSVALTHPLDVIKTHITVIAPTAATIKNVTKGIYRDLGIIGFFRGLSAGILNIAPFAALNFTFYETIKEKTQQYILKSPPLYAPSIYGAISGGLTMTILYPLDVVKRRIMLQHFDRNQLPIYKNFIDAIIKITKTEGISALYKGIRPAYLKVIPTVSINFLIYEGAITLFEKK
What is the function of this protein?
Calcium-dependent mitochondrial solute carrier.  Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (By similarity).
What are the official names of this protein?
Mitochondrial substrate carrier family protein A.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YBEY_NOVAD
Sequence: MSAPILEMDIDPVWGDAIDWEDIASRAAEAAAKVAPELAHENLLVSVVLADDDEVHALNKQWRAKDKPTNVLSFPMLSREEVLHAAADEGAPGMLGDMILAHGVCTREAAEKGVSVETHATHLVVHGLLHLAGYDHELGEAEAEEMENLERKALALMGIADPYAVED
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17B_YEAST
Sequence: MARYGATSTNPAKSASARGSYLRVSFKNTRETAQAINGWELTKAQKYLDQVLDHQRAIPFRRFNSSIGRTAQGKEFGVTKARWPAKSVKFVQGLLQNAAANAEAKGLDATKLYVSHIQVNQAPKQRRRTYRAHGRINKYESSPSHIELVVTEKEEAVAKAAEKKVVRLTSRQRGRIAAQKRISA
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L17-B, L20, Large ribosomal subunit protein uL22-B, YL17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RNPA_BURMA
Sequence: MQASAAFPKAARLLKTDEFSSVFRLRPWRRTAHFVIYGKPTGRDARLGLVIGKKYAARAVTRNLVKRLAREAFRTRRAEFAGWDILLRLHTRFDKKAMPSAASAPLAALCAGEIRELLDRAAREVARRNGAKPASE
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RECO_RICAE
Sequence: MNIKDIGVIIAKKTLKENTFIITVFTKNHGLYSGVVKEFSKKSKFIYQEGNIIDFLWQARLHEHIGMAKCELIKSYTGYFITNKAKLYAFNSVISLIKELFHEREEHSKFFSFLINYLDNLSKNFCFRDYINFELALLAETGYKLDLTKCGVSHVTTDLIYVSPKSARALSYAVGKPYKDKLLMLPRFLLSDNSEITLEEKRQALALTNYFFNRYLFHNNRQVEARQTFIEYTLNNF
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.