PharMolix/UniProtQA huggingface dataset:
Protein: TS23B_MAIZE
Sequence: MAADEARSVSRLHSEEDMHGKHHSTLWGDFFLHHVPCRPGQYLIMKDNVEIMKEEVKKMLLDVGSSDLSHKLDCIDTLERLGLDYHYTKEIDELMCNVFEARDQDLDLTTTSQLFYLLRKHGYHISSDVFLKFRDDKGDIVTNDARCLLRMYEAAHVRVNGEEILDNILIHTKRQLQCIVDDLEPTLQEEVRYALETPLFRRLNRVQARQFISTYEKSTTRINMLLEFSKLDFNILLTLYCEELKDLTLWWKEFQAQANTTIYARDRMVEMHFWMMGVFFEPQYSYSRKMLTQLFMIVSVLDDLYDSHCTTEEGNAFTAALQRWDEEGVEQCPTYLRTLYTNIRATIKAIEEDLNFQNNKHAKLVKGLIIDMAMCYNAETEWRDKKYVPATVDEHLKISARSSGCMHLVSQGFISMGDVATSEALEWASTYPKIVRAVCIIARLANDIMSYKREASNNTMVSTVQTCAKEYGTTTVEQAIEKIRELIEEAWMDITHECLRQPQPKALLERAVNLARTMDFLYKDADGYTDSRSIKGILDSLYVHLID
What is the function of this protein?
Component of the volatile terpenes biosynthesis pathways (PubMed:30187155).  Sesquiterpene synthase that converts farnesyl diphosphate to (E)-beta-caryophyllene (PubMed:18296628).  Involved in indirect defense by producing volatile signals that attract natural enemies of leaf herbivores such as Chilo partellus and root herbivores like the western corn rootworm (WCR, Diabrotica virgifera) and fall armyworm (Spodoptera littoralis and Spodoptera frugiperda) (PubMed:18296628, PubMed:28428873, PubMed:29151152).  Deters leaf herbivores by triggering (E)-beta-caryophyllene production upon insect (stemborer C. partellus) egg deposition; (E)-beta-caryophyllene attracts the parasitic wasp Cotesia sesamiae which lays eggs on the larvae of C. partellus, which is ultimately fatal (PubMed:28428873).
What are the official names of this protein?
(E)-beta-caryophyllene synthase, Terpene synthase 23.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPK1_HELPJ
Sequence: MNRFFNRELSWLAFNTRVLNEAKDESLPLLERLKFLAIYDTNLDEFYMIRVAGLKQLYEHKIASKGIDGASPEEQLEKIKHYLAHEIEERELEFQKIQALLFKKGLCITPYNELNLEQKAKAKTYFKEQLYALVLPFKLDSSHTFPPLANLTFALFAHIKDKETQSASYALIKLPSFIFRFVELEKGLFALAEEIVEAHLEELFLEHEILDCMAFRVTCDADIAITEDEAHDYADLMSKSLRKRNQGEIVRLQTQKGSQELLKTLLASLRSFQTHSYKKHKLTGMHIYKSAIMLNLGDLWELVNHSDFKALKSPNFTPKIHPHFNENDLFKSIEKQDLLLFHPYESFEPVIDLIEQAASDPTTLSIKMTLYRVGKHSPIVKALIEAASKIQVSVLVELKARFDEESNLHWAKALERAGALVVYGVFKLKVHAKMLVITKKTDNQLRHFTHLSTGNYNPLSAKIYTDVSFFSAKNEIANDIIKLFHSLLTSSATSNTLETLFMAPKQIKPKIIELIQNEMNHKQEGYIILKANALVDSEIIEWLYQASQKGVKIDLIIRGICCLKPQVKGLSENIRVYSIVGKYLEHARIYYFKHENIYFSSADLMPRNLERRVELLIPATNPKIANKLLHILEIQLKDTLKRYELNSKGRYAKISNPNDPLNSQDYFEKQALKTL
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: FUZ7_USTMA
Sequence: MLSSGAGSSIRKKRNFKGLQLAESPLASPVDASATTPSHKPGEGSAASNASTIGKSSAVTPGGSLALPVKNGLDTEPNSGANYHNKLTQQLANLELGVEYKLDLKNEDLKTLSELGAGNGGTVTKVLHEKSGTVMAKKVVFIDAKPSVRKQILRELQILHECNSPYIVSFYGAYLNEPHICMCMEFMQKDSLDGIYKKYGPISPEICGKIAVAVSHGLTYLYDVHRIIHRDVKPSNILVNGAGQIKICDFGVSGELINSIADTFVGTSTYMSPERIQGDQYSVKSDVWSLGVSIIELALGRFPFAENEEDDDSDADNNYTNEDLAGTLSPTKPAPMISLGQNEKQRRRKSKPAGVSLEGSSHQMSILDLLQHIVNEPPPKLPEGRFPKHMEEFVNLCLLKDPAKRPTPKDLTKHQYVIDADAAKVDLQAWADGMK
What is the function of this protein?
Protein kinase that is necessary for a-locus-dependent processes, such as conjugation tube formation, filament formation, and maintenance of filamentous growth, and for a-locus-independent processes, such as tumor induction and teliospore germination.
What are the official names of this protein?
Dual specificity protein kinase FUZ7.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Protein: AT2B4_HUMAN
Sequence: MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKTSPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPEDENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKEEITKDAEGLDEIDHAEMELRRGQILWFRGLNRIQTQIDVINTFQTGASFKGVLRRQNMGQHLDVKLVPSSSYIKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEENPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV
What is the function of this protein?
Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416).  By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity).
What are the official names of this protein?
Plasma membrane calcium-transporting ATPase 4, PMCA4, Matrix-remodeling-associated protein 1, Plasma membrane calcium ATPase isoform 4, Plasma membrane calcium pump isoform 4.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Protein: SECA_CLOBL
Sequence: MGILNKIFGTYSERELRRVNPIVNKIEALDEKMQSLKDEDFKLKTEEFKSRLEKGEKLDDILPEAFALVREAANRTIGLKHYREQLIGGVVLHQGRIGEMKTGEGKTLVATLPAYVNALTGKGVHIVTVNDYLAKRDRDLMAPVYEFLGLKVGVILHNLNNEERQEAYGSDITYGTNSEFGFDYLRDNMVVYKEERVQRKLNFSIVDEVDSILIDEARTPLIISGQGEKSTEFYKVADYFTKSLIAEKDFTIDEKANSAMLTDEGVNKAENFFKVDNYADAENMEIQHHVVQALKANYVMKKDKDYMIKDGEILIVDEFTGRAMEGRRYSDGLHQAIEAKEGVRVERESKTLATITYQNYFRMYNKLSGMTGTAQTEENEFREIYGLDVIVIPTHEPIARIDNADVVYKSEKGKFKAIVDEIVERYKKGQPMLVGTVSIEKSEMLSSMLKKKGVPHQVLNAKYHEKEAEIISHAGEYGMVTIATNMAGRGTDIKLTKEAEEAGGLMIIGTERHESRRIDNQLRGRSGRQGDPGESRFFVSLEDDLMRIFGSERIQGIVDKLGLAEDEAIESKMVSSAIESAQKKVEGNNFDIRKTLLQYDDVINKQREIIYKQRSEVLEGEDLKDQIRDMIRDVVYTAVNSHISGVEEEFETELQNLVNYLEDICLPKALVKVKDISNLSDEEIKEKLLEAVENIYIHKEKEIGEEQIREIERVILLRVVDTKWMDHIDDMDHLKQGIGLRAYRQQDPVQAYQFEGSEMFEEMIYNIKVDTVRYLFHVEVEKAPEREKVAKETSTNYDEDSVKKQPIKKENRIGRNDMCPCGSGKKYKNCCGRMA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: CHEY1_HELPY
Sequence: MKLLVVDDSSTMRRIIKNTLSRLGYEDVLEAEHGVEAWEKLDANADTKVLITDWNMPEMNGLDLVKKVRSDSRFKEIPIIMITTEGGKAEVITALKAGVNNYIVKPFTPQVLKEKLEVVLGTND
What is the function of this protein?
Chemotactic response regulator protein that modulates the rotation direction of bacterial flagellar motors.  Plays an important role in the colonization and infection of Helicobacter pylori (PubMed:10722597).  Upon phosphorylation by CheA, interacts with the flagellar motor protein FliM to cause clockwise flagellar rotation and bacterial reversals, as opposed to straight swimming when CheY1 is not phosphorylated (PubMed:20207758).
What are the official names of this protein?
Chemotaxis protein CheY1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZC11A_CHICK
Sequence: MSKQGDDCYFYFYSTCNKGDNCPFRHCEAALGNETICTLWKEGRCFRNVCRFRHMEIDKKRSEIPCFWENQPGGCQKSNCAFHHTKGRYVDGLFLPPSKTTLPSPPESADDDLKAAQITLQQNKLSVQSNPSPQLRGVMKVENSENVPSPTHPPVVINAADDDEDDDDQLSEEGEETKTPVQQPAEENHNGLRIISTRKSNADTKQDDSLNFGIKTLEEIKLKKQKEKTKKQSEGPSGVPAHPLQSRTVPVPEKENVRTVVRTVTLSAKQGEEPVIRLNIAEKPGKRKGSVADVSGLPLKRSLAERLGRKIEVDKAPRREKGAKPAGEIHVKTLEEIRLERANQRGETLTAPQAEVCCKVEDPSSGVRPPPAVRIKTFSEALAERKQRRLEEEKQKLEEFLTEKRAEGERKKQRILPPSVPGKVKLEEPTRKIKPLEEVHIKTLEEIKQEKALRMQQSGENVPAPAAQPGPAPAGRKLLRITKLAAPGKEEKKTVELSRASPKAVSAPAEPSNQSAPNSKAQVKSLEGTVKEKLQLRQPEKLKKEVAAVPSATEETVKAKCKVCVKPSDSKASTPTKRALKRKAAEISPSAVAAVKPLSSTETEEPPAKKAALTAAPALPEDSLLTKPGVEKPPSSLELQLGSQADSVEQSGDSSSASASSQSVAKAQQLSSTGAGKAPLSVEDDFEKLIWEISGGKLEAEIDLDPGKDEDDLLLELSEMIDS
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 11A.
Protein: OR4D6_HUMAN
Sequence: MDQINHTNVKEFFFLELTRSRELEFFLFVVFFAVYVATVLGNALIVVTITCESRLHTPMYFLLRNKSVLDIVFSSITVPKFLVDLLSDRKTISYNDCMAQIFFFHFAGGADIFFLSVMAYDRYLAIAKPLHYVTMMRKEVWVALVVASWVSGGLHSIIQVILMLPFPFCGPNTLDAFYCYVLQVVKLACTDTFALELFMISNNGLVTLLWFLLLLGSYTVILVMLRSHSGEGRNKALSTCTSHMLVVTLHFVPCVYIYCRPFMTLPMDTTISINNTVITPMLNPIIYSLRNQEMKSAMQRLQRRLGPSESRKWG
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 4D6, Olfactory receptor OR11-250.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PLSX_SHELP
Sequence: MTNLTLALDAMGGDFGPRITVPATLQALRLYPFLHVIMVGDRSQIEPLLSHLESDLLSRIELVHTTEVVKMCDRPVHALRNCKQSSMRLAIELVRDKKAQACLSAGNTGALMAISKVLLKTLPGIDRPALVSCLPAVNHKPVYLLDLGANVSCCSETLFQFAVMGSVLCEAVDKNPAPKVALLNVGIEEIKGNDQVQQAGQLLQQSPQLNYAGFIEGDDIYSGNVDVIVCDGFVGNITLKTSEGIARLLVHQLKKGLTQGFFVRLLAKLIAPRINSVLNQMNPDHYNGASLIGLRGIVVKSHGSADESAYLQAISLAVTEAQRRLPKMIEERLESILLDINN
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: TX130_LYCSI
Sequence: MMKVLVVVALLVTLISYSSSEGIDDLEADELLSLMANEQTRKECIPKHHECTSNKHGCCRGNFFKYKCQCTTVVTQDGEQTERCFCGTPPHREAAELVVGFGKKIFG
What are the official names of this protein?
U1-lycotoxin-Ls1o, Toxin-like structure LSTX-A30.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 04 (U1-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: INT13_MOUSE
Sequence: MKIFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELMAALATVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRPKKELSPVLTSEVHSVRAGRHLATKLNVLVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLRSGDSHSGSSSREGPFKETVTLKWCTPRTNSIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLTPFLDPRYKIDASLEIPLERAKDQLEKHTRYWPMIISQTTIFNMQAVVPLAGVIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPVSTVGTRGKGPKRDEQYRIMWNELETLVRAHISNSEKHQRVLECLMACRSKPPEEEERKKRGRKREDREDKSEQAGKEHGTEKARPDADRLKGILERGKEELAEAEVIKDSPDSPEPPNKKPLVETDETPHMEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEENGEEVGLTGGPRTAIPFLKCPRSPVVNRMETTENGKASRQ
What is the function of this protein?
Crucial regulator of the mitotic cell cycle and development.  At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling.  At G2/M phase, may be required for proper spindle formation and execution of cytokinesis.  Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
What are the official names of this protein?
Integrator complex subunit 13, Cell cycle regulator Mat89Bb homolog, Protein asunder homolog, Spermatogenesis-associated protein 30.
What is the protein family that this protein belongs to?
Belongs to the asunder family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M.
Protein: PSD_COLP3
Sequence: MSSKNSLSDKIKITFQYIMPKHAISRLVGKLAAAKMGWLTTKLISMFIKAYGINMNEAKLKKASDFDTFNNFFTRELEEGARIIDNDENTICYPVDGAISQQGDIIDGQLIQAKGFNYSVTSLLGGDEKTAAPFQGGKFSCIYLAPKDYHRIHMPMAATLREMIYVPGELFSVNPLTAQNVPDLFARNERVVAIFDTEMGELAMVLVGATIVASIETTWAGTITPPAGKDIFRWQYPKDGADAITFEKGDEMGRFKLGSTVVSTFAPNMISEFATDAGPGTVTRLGEIYAALDKSAS
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CHO2_BOTFB
Sequence: MSTSSMKSQDSNGLRERINNGSATNDDNMTARCGSEPPSEDFELDKDKKTFGRTPDGTIPQTHDMVSQLLDPRQPKNLSDLIVLVILALHIFALYALPSSLKRPVFAVIFLFWRGCYNVGIGYLLHIQSHHKRIVAWAKKWNLFENPVTGKNPRPWLYQLIKTELETKIPEDYKFEQAPIEYNTWLVFRRVVDLILMCDFTSYCLFAIACGGAPSDEGLVMSTLRWGAGIILVLFNLWVKLDAHRVVKDYAWYWGDFFYLIDQELTFDGVFEMAPHPMYSVGYAGYYGISMMAASYSVLAISIVAHMAQFAFLLVVENPHIDKTYNPPPPRKHQDNPTPSDIDHANALASSKEGLEYSLDSSPTQTPPLNTTQPLAVHNLMGLGNIDLFRITDVSILLLLGYVFLITALTPSTPVYQALFVINAMFWRLWYSVGLGIILDRQSSKKMWTRHFVKYGDSTEEAWRQWKGMYHLSMTMCYASFIAATWKMYSIPSDWAYGLVLLRHVLGAGLVSLQLWTAISIYESLGEFGWFFGDFFFDHAPKLTYSGIYRYLNNPERIIGLAGIWGAVFITGSRAIFCLALLSHTLTLAFLQFVEKPHMQKLYGRNLRSEAGLSKSIKRSLPPQIKKWHGNVDRVLEETGHFVEEFLDAARPKLAAGVSTIFRDTSALFSQYPARLTLTRIAPDLAGYDPRDYSVTIEGTSSDSALHKRTTSKEGITARIPQERMDGFKPLVFEYGAPIKVKWTAPTKHSKADWIVTRIPSAGRWVATVPNEYESSPADQGILVSNRFVSGSKRIDGSTQDYVEGEMIFEGDKLFWTQGVFEFRYHHDGKHNVMAISLPFEIRIPRFDDENSNVNITLDSDNSQSQSLIRSAVEQALLPVVRNCFDRDPDIAPNSVDESFGVLVARDGKYPRRVVHAVHFMFGIEFAPEVVRADGNVRNLAWRICNAKQVLAPYSMSHSKGTNTPDVDGEKA
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NLK_BOVIN
Sequence: MPNVFQNLVSCKRVFRELKMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
What is the function of this protein?
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination.  Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2.  Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1.  The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing.  The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs).  Negative regulator of the canonical Wnt/beta-catenin signaling pathway.  Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1.  Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes.  Negative regulator of the Notch signaling pathway.  Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1.  Negative regulator of the MYB family of transcription factors.  Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP.  Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself.  Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1.  Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members.  Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner.
What are the official names of this protein?
Serine/threonine-protein kinase NLK, Nemo-like kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity).
Protein: NUOH_SALPB
Sequence: MSWITPDLIEILLSILKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLSFAIVPVSPNWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTVSYEVFLGLSLMGVVAQAGSFNMTDIVNNQAHLWNVIPQFFGFVTFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTVSALMVTLFFGGWHGPFLPPFVWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKVCLPLTLINLLVTAAVILWQAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBIB_VIBCH
Sequence: MKPAELKRLYRIVKVQLEYGLDELLPEHHLTRAPLLARKSLFWLRNQHADKALGDRLRLALQELGPVWIKFGQMMSTRRDLFPPHIADPLAMLQDKVAPFDGLQAKQLIEEELGAPLETWFDDFDIKPLASASIAQVHTAKLKSNGRDVVLKVIRPDIRPQIDADIKLMYRVARIVAKALPEARRLKPVEVVREYEKTLLDELDLRREAANAIQLRRNFENSEELYVPEVLTDFCNETVMVSERIYGIQVSDLAGLHANGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPNHPENPQWIGLDCGIVGTLNSEDKRYLAENFLAFFNRDYRRVAQLHVDSGWVPLDTNVDEFEVAIRMVCEPIFAKPLCEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGLGRQLYPQLDLWQTAKPFLEKWMANQVGPQAFLHALKERAPLWFEKMPELPELLYDSLKQGRNLNQRLDNLYQGYRQSKRQQGTGKFLFGVGATLVVCSAIWISNQLEPLAIGSATIGVLCWLLSWRAYRQ
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CG30_NPVAC
Sequence: MEFVKLQCNICFSVAEIKNYFLQPIDRLTIIPVLELDTCKHQLCSMCIRKIRKRKKVPCPLCRVESLHFNVYSVNRNVVDVIKCSASSVAQWNKINANFDAASLASVLFEKSLLDDAEDNNANADDTMLSEAQAILKKLQVDIAEQTQLNIKQQLDLDKLQQTSVSMQEKLDKIKSDYNNMHKSFKELQLKRITTEKALKSLNDDYAKLASKNAKLSSENKVLSNKNIELIKHKNLLQNEYTTLQSYKCITNATITTNVTINVD
What is the function of this protein?
Plays a role in the proper expression of late and very late genes.
What are the official names of this protein?
Zinc finger protein CG30.
What are the subcellular locations of this protein?
Host nucleus.
Protein: AROG_SOLLC
Sequence: MALSTNTTTNSLLSNKSLLQNQPLLSSPSKNAFFSNKSTKTVRFVQPIAAVHSSDSNKNPIVSDKPTKSSPPAATATTAPAPAVTKTEWAVDSWKSKKALQLPEYPDQEELRSVLKTIDEFPPIVFAGEARSLEERLGEAAMGRAFLLQGGDCAESFKEFNANNIRDTFRILLQMGAVLMFGGQMPVIKVGRMAGQFAKPRSDSFEEKDGVKLPSYRGDNVNGDAFDVKSRTPDPQRLIRAYCQSAATLNLLRAFATGGYAAMQRINQWNLDFTEHSEQGDRYRELASRVDEALGFMTAAGLTMDHPIMKTTEFWTSHECLLLPYEQSLTRRDSTSGLHYDCSAHFLWVGERTRQLDGAHVEFLRGIANPLGIKVSDKMDPSALVKLIEILNPQNKAGRITIITRMGAENMRVKLPHLIRAVRRAGQIVTWVSDPMHGNTIKAPCGLKTRPFDSIRAEVRAFFDVHDQEGSHPGGVHLEMTGQNVTECIGGSRTVTFDDLSSRYHTHCDPRLNASQSLELSFIIAERLRKRRLGSQSTLGQ
What is the function of this protein?
Involved in maintaining the supply of chorismate for the biosynthesis of the aromatic amino acids and other chorismate-derived metabolites.
What are the official names of this protein?
Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 2, DAHP synthase 2, Phospho-2-keto-3-deoxyheptonate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II DAHP synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RPOC_HISS2
Sequence: MKDLVKFLKAQSKTSEDFDVIKIGLASPDMIRSWSYGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQAKVRRERMGHIELASPVAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYIVIEPGMTDLERGQLLTEEQFLDAEDRWQDEFDAKMGAEAIQALLRDMDLEVECETLREELQSTNSETKRKKITKRLKLLESFIQSGNKPEWMVMTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLIAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNRRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLHLHQCGLPKKMALELFRPFIYAKLESRGFATTIKAAKKMVEREDAIVWDILADVIREHPILLNRAPTLHRLGIQAFEPILIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDKVNGKGEGMLLQDSREAEKAYRTGQAELHSRVKVRITEYVKNAIGEFEPQTHLVDTTIGRAILWMIAPKGMPFSLFNQTLGKKAISKLINESYRRLGLKESVLFADHIMYTGFAYAARSGSSVGIDDMVIPQKKYEIISAAEEEVAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMENLSQEEVINREGQPEKQASFNSIFMMADSGARGSAAQIRQLAGMRGLMARPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVIIEDDCGTHEGIVMTPLIEGGDVKEALRDRVLGRVAAEDILKPGTNEVLISRNTLLDEKLCDVIDENSVDSIKVRSVVTCDTDFGVCAKCYGRDLARGHLINQGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASAAAKESSVQVKNTGTLRLTNVKFVTNKEGKLVLTSRNTELTIIDTFGRTKEHYKVPYGAVLNHADGEEVTAGETVANWDPHTMPVISEVSGFVKFVEIVDGLTVTRQTDELTGLSSIVVQDVGERATAGKDLRPALKLVDAQGNDIFIPGTDVMAQYFLPGKAIVSLDDGAEVFVGEPLARIPQESVGTKDITGGLPRVADLFEARKPKEPAILAEISGIVSFGKETKGKRRLLITPMEGETYEEMIPKWRQLNVFEGELVQRGDLISDGAETPHDILRLRGVHAVTDYIVNEVQEVYRLQGVKINDKHIEVIVRQMLRKAIITNAYDSEFLEGEQVEVARVKIVNRKRAEEGKPLVEFERELLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGFAYHQNRQKNRLVGGMENTTEVKLSAVDEEEIASEFTFSAEDATANLAEMLNMADDAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.