PharMolix/UniProtQA huggingface dataset:
Protein: RNPH_BACCN
Sequence: MRVDGREVRELRHVHIHTNYLKHPEGSVLIEVGDTKVICSATVEERVPPFMRGEGKGWVTAEYAMIPRATEQRTIRESSKGKVTGRTMEIQRLIGRALRAVVDLEVLGERTVWIDCDVIQADGGTRTASITGAYVAMVLAFEKLLQAEKVTKIPVKDYLAATSVGILEEQGVVLDLNYAEDSKADVDMNVIMTGKGHFVEVQGTGEEATFSRAQLNELLDAAEHGILQLIEKQKEALGDIVSHIE
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: Y1016_GEOSL
Sequence: MLSILLENPLLVLFLVAAIGYPLGRIKIRGSSLGVAAVLFVGLAMGSLHPELKLPEIVYVLGLALFVYTIGLSSGPAFVASLKREGIRNNALIIGMLLVAAGLVVGAQRLLGFKGTVTAGLFAGSLTNTPALAGALETIKHIASPELRELLLAEPVVGYSVAYPMGVMGVVLAISLVQKLWNVDYGEEGKRLRLAGTASEALRSMTVRIAWPGAGRHTVAELARHEKWDVIFGRIRRGDSYLLTGPQVRFQPGDLVTAVGTETELRRVAAFLGEVSEEEITVDRSEYDYRRIFVSNPRVAGRQLGELNLFENYGATVTRVRRGDDDFLPHDDMVLELGDRVRVVTHRDHMAEVTAFFGDSYRAVSEVDILTFSLGLALGLLLGIIPIPLPGGITLKLGFAGGPLIVALILGTIGRSGSMVWSLPYSANMTLRQIGLVLFLAGVGTRAGYGFVTTLAKGGGLAIFAAGAVVTCLTALATLWIGHKLMKIPMSILIGMVAGLQTQPAVLGYALEQTGNDLPNIGYASVYPVATISKILIVQILLTMLM
What are the official names of this protein?
Uncharacterized transporter GSU1016.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TATA_METC4
Sequence: MGSMSVWHWVIVAVVVMLLFGRGKVSELMGDVAKGIKAFKKGMADDETQPNTATSVPPVGPNDPVRTLPHQGAPGTAPQPPHVQPHVSAGDHKAV
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: GLNA_PYRHO
Sequence: MVRKVNIIKGNEGQGKRIKFVQLIFVDINGMPKGMEVPITRLEEAIEEGIAFDGSSVPGFQGIEDSDLVFKADPSTYVEVPWDNVARVYGYIYKDGKPYEADPRGVLRRTLERLEKLGIKVYIGPEPEFYLFKKNGSWELEIPDVGGYFDILTLDKAKDIKREIAEYMPYFGLTPEVLHHEVGKAQHEIDFRHDEALKTADNIVSFKYIVKAVAEMHGLYATFMPKPIYGMPGNGMHLHISLWKDGENIFKGEEGLSETALYFIGGLLKHAKALAAVTNPTVNSYKRLVPGYEAPVYISWGYKNRSALIRVPAFWGNGARIEYRCPDPSANSYLAFAAILMAGLDGIKHKIEPFAYVEENVYEMDEKRREEIGIDMLPENLGEALDELERDKVVKEALGGAYRNFVGYKRKEWEEYLDYLEAKNLPKDTKNVTEWELERYFFI
What is the function of this protein?
Probably involved in nitrogen metabolism via ammonium assimilation.  Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I alpha, GSI alpha.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_STRA1
Sequence: MSKQVFEMIFAGKKLVVETGQVAKQANGSVVVRYGDSTVLTAAVMSKKMSTGDFFPLQVNYEEKMYAAGKFPGGFNKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSFDENASAPMAAMFGSSLALSISDIPFNGPIAGVQVAYVDGNFIINPTAQEQEASALELTVAGTKEAINMVESGAKELSEEIMLEALLKGHEAVCELIAFQEEIVTAIGKEKAEVELLQVDPELQAEIIATHNIALQAAVQVEEKKAREAATEAVKEVVIGEYEARYAEHEEYDRIMRDVAEILEQMEHAEVRRLITEDKIRPDGRRVDEIRPLDAEIDFLPQVHGSGLFTRGQTQALSVLTLAPMGEAQIIDGLTPEYKKRFMHHYNFPQYSVGETGRYGAAGRREIGHGALGERALEQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGTNYTVLTDIQGLEDHFGDMDFKVAGTREGITALQMDIKIEGITPQILEEALAQAKKARFEILDVLHGAIAEPRPQLAPTAPKIDMIKIDVDKIKVVIGKGGETIDKIIAETGVKIDIDEEGNVSIFSSDQAAIDRTKDIIASLVREAKVGEVYHAKVVRIEKFGAFVNLFDKTDALVHISEIAWTRTANVADVLEIGEEVDVKVIKIDDKGRVDASMKALLPRPPKADNPKKES
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNUB_BUCAP
Sequence: MFELIYPGWLAGILLSFATGPLGSFIIWRRISSFGDTLSHSSILGLAISILFQIDSFYTELFFMSFLAIILVWMEQLLSVSLETILSIISHSSLSLGIICISLMSTSHHIDLSNYLFGDLLLVTVFDLCIIALGSLIVLTILFFRWNSILLLTVNEELAQIDGVNIFYARLTLMLTTAICISIAIKFVGVLLITSLLIIPPATAQIFSNSPEKTIGFSILISIISVTGGIFLSFFYNVPTSPSIVLFSSCVYLLSNIKKLI
What is the function of this protein?
Involved in the high-affinity zinc uptake transport system.
What are the official names of this protein?
High-affinity zinc uptake system membrane protein ZnuB.
What is the protein family that this protein belongs to?
Belongs to the ABC-3 integral membrane protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MATK_ATRLA
Sequence: MEKFQSYLGLDRSQQHYFLYPLIFQEYIYVLAHDHGLNRSILLENAGYDNKSSLLIVKRLITRMYQQNHLILSVNDSKQTPFLGDNKNFYSQVMSEVSSIIMEIPFSLRLISSLERKGVVKFDNLRSIHSIFSFLEDNFSHLNYVLDILIPYPAHLEILVQALRYWIEDASSLHLLRFFLHEYHNRDSLITSNSKKASSSFSKRNHRLFFFLYTSHVCEYESGFIFLRNQSSHLRSTSSGALLERIYFYGKIEHLAEVFTRAFQANLWLFKDPFMHYVRYQGKSILASKGTFLLMNKWKYYFVNFWKSYFYLWSQPGRIYINQLSNHSLDFLGYRSSVRLKPSMVRSQMLENAFLIDNAIKKFDTIVPIMPLIGSLAKSKFCNALGHPIGKAIWADLSDSDIIDRFGRIYRNLSHYHSGSSKKKSLYRVKYILRLSCARTLARKHKSTVRAFLKRFGSELLEEFFTEEEQVFSLTFPRVSSISRRLSRRPIWYLDIICINDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS11_CERS1
Sequence: MARDKTRMKRKERKNIAAGVAHVNSSFNNTKILISDVQGNAISWSSAGTMGFKGSRKSTPYAAQMAAEDAAKKAQDHGMKTIEVEVQGPGSGRESALRALAAAGLNITSIRDVTPMAHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: LPXC_CUPNH
Sequence: MLKQRTIKSLVKTVGIGLHSGRKVTLTLRPAPADTGIVFTRVDLPEAVEIPVAASAIGDTRLASVLQKDGARVSTVEHLMSACAGLGIDNLYVDVDAEEIPIMDGSAASFVFLLQSAGIEEQNALKTFIRVKKAVEVREGDKLARLEPFFGFKLSFTIDFRHPAVDKTGQTFSIDFADTSYVREIARARTFGFAHEVEALREMGLARGGSLDNAIVLDEHRMLNNEELRYGDEFVRHKILDAIGDLYVVGHPLIGAYVANKSGHGLNNQLLRALLADQEAYELVTFDRVEEAPVAFLPQAQPAFA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: COR13_PAPSO
Sequence: MESNGVPMITLSSGIRMPALGMGTAETMVKGTEREKLAFLKAIEVGYRHFDTAAAYQSEECLGEAIAEALQLGLIKSRDELFITSKLWCADAHADLVLPALQNSLRNLKLDYLDLYLIHHPVSLKPGKFVNEIPKDHILPMDYKSVWAAMEECQTLGFTRAIGVCNFSCKKLQELMAAAKIPPVVNQVEMSPTLHQKNLREYCKANNIMITAHSVLGAICAPWGSNAVMDSKVLHQIAVARGKSVAQVSMRWVYQQGASLVVKSFNEGRMKENLKIFDWELTAENMEKISEIPQSRTSSADFLLSPTGPFKTEEEFWDEKD
What is the function of this protein?
Reduces codeinone to codeine in the penultimate step in morphine biosynthesis.  Can use morphinone, hydrocodone and hydromorphone as substrate during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrate during oxidative reaction with NADP as cofactor.
What are the official names of this protein?
NADPH-dependent codeinone reductase 1-3.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Note=Present in the cytosolic part of laticifer cells that secrete latex.
Protein: SDO1L_YEAST
Sequence: MSTVTKYFYKGENTDLIVFAASEELVDEYLKNPSIGKLSEVVELFEVFTPQDGRGAEGELGAASKAQVENEFGKGKKIEEVIDLILRNGKPNSTTSSLKTKGGNAGTKAYN
What is the function of this protein?
May play a role in RNA metabolism, rRNA-processing, and in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 3.
What is the protein family that this protein belongs to?
Belongs to the SDO1-like family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYI_SODGM
Sequence: MTDYKNTLNLPDTGFPMRGDLAKREPGMLERWYEQDLYGIICQARKGKKTFILHDGPPYANGSIHIGHSVNKILKDIIIKSKGLMGYDSPYVPGWDCHGLPIELKVEQLIGKPGEKVSAAEFRTACRRYAAEQVEGQKKDFIRLGVLGDWEHPYLTMNFATEANIIRALGKIIANGHLHKGAKPVHWCIDCRSALAEAEVEYYDRTSPSIDVAFAADDVRAVAAKFGAADFAGQISLIIWTTTPWTLPANRAIAVHPDFDYQLVEVEGQGYILAADLVDSVMARAGITCWTVLGSAKGSALELLRFRHPFMGFDVPAILGQHVTLDAGTGAVHTAPGHGPDDYVIGQQYGLEVANPVGPDGCYLPGTLPALDGLQVFKANDVVINLLCDSGALLHVEKLQHSYPHCWRHKTSIIFRATPQWFVSMDQRGLRKQSLAEIKDVQWIPGWGQARIETMVANRPDWCISRQRTWGVPMALFVHNETEALHPRTIELMESVAQRVEQDGIQAWWDLDPAEILGDDAAHYHKVPDTLDVWFDSGSTHSSIVAVRPEFEGHAPDMYLEGSDQHRGWFMSSLMISTAMHGKAPYRQVLTHGFTVDGQGRKMSKSVGNVVSPQQVMDKLGADILRLWVASTDYTGEMAVSDEILKRSADAYRRIRNTARFLLANLNGFDPARHSVSPEQMVVLDRWAVGRAQAAQAEIVAAYDSYDFHNVVQRMMQFCSVEMGSFYLDIIKDRQYTTKADSIARRSCQTALYHIIEALVRWMAPIMSFTADEIWGFMPGERAQYVFTEEWYDGLFGLDAAQPLNDAYWQILLQVRSETNKVIEQARADKRIGGSLEARVTLYAEPDLAASLRELGDELYFTLLTSNAVVADYADAGDDAVQCEGLKGLKIALAKAEGEKCPRCWHYETDIGQHADHPEICGRCVTNVAGPGEERKFV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDM2A_MOUSE
Sequence: MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQWPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLISVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKDFQKESLSMDMELNELESGNGDEEGVDREARRMNNKRSVLTSPVANGVNLDYDGLGKACRSLPSLKKTLSGDSSSDSTRGSHNGQVWDPQCSPKKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELASSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSDKAQKRKIEESDEEAVQAKVLRPLRSCEEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRPNPRVLMQHCPARNPQHGDEEGLGGEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRKELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPTDKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLFFLRRIANVTLIDLRGCKQITRKACEHFISDLSINSLYCLSDEKLIQKIS
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:32584788).  Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'.  May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation.  Required to maintain the heterochromatic state.  Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere.  Required to sustain centromeric integrity and genomic stability, particularly during mitosis (By similarity).  Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (By similarity).
What are the official names of this protein?
Lysine-specific demethylase 2A, F-box and leucine-rich repeat protein 11, F-box/LRR-repeat protein 11, JmjC domain-containing histone demethylation protein 1A, [Histone-H3]-lysine-36 demethylase 1A.
What is the protein family that this protein belongs to?
Belongs to the JHDM1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Chromosome. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2 (By similarity).
Protein: FUT5_HYLLA
Sequence: MDLLGAAKPQWPWRRCLAGLLFQLLVAVCFFSYLRVSRDDATGSPRPRLMAVEPVTGAPNGSRCQDSMAAPARPTLLILLWTWPFNTPVALPRCSEMVPGAADCNITADSNVYPQADAVIVHHWDIMRTPSANLPPPTRPQGQRWIWFSMESPSNCRHLEALDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWEPGSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLAPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAWFN
What is the function of this protein?
Catalyzes preferentially the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl-beta-D-glucosamine (GlcNAc) of an N-acetyllactosamine unit (type 2 chain) of an oligosaccharide, or a glycoprotein- and a glycolipid-linked N-acetyllactosamine unit via an alpha (1,3) linkage and participates in the surface expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.  Preferentially transfers fucose to the GlcNAc of an internal N-acetyllactosamine unit of a poly-N-acetyllactosamine chain acceptor substrate.  Also catalyzes to a lesser extend the transfer of L-fucose to the GlcNAc of a type 1 (beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl) or H-type 1 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc) chain oligosaccharide via an alpha (1,4) linkage.  Preferentially catalyzes sialylated type 2 oligosaccharide acceptors over neutral type 2 or H type 2 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc) oligosaccharide acceptors.  Lactose-based structures are also acceptor substrates.
What are the official names of this protein?
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5, Fucosyltransferase 5, Fucosyltransferase V, Fuc-TV, FucT-V, Galactoside 3-L-fucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 10 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Protein: ATG7_HUMAN
Sequence: MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGTALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEALECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQYPGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYEREGFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine.  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.  Required for autophagic death induced by caspase-8 inhibition.  Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (PubMed:34161705).  Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.  Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.  Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, APG7-like, hAGP7, Ubiquitin-activating enzyme E1-like protein.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
Protein: KHPB_CLOSY
Sequence: MDMVTVTAKTVEEAVTKALIELQTTSDKLTYEIVEKGSAGFLGIGSKPAIIRAKRKETLQDKAIEFLEQVFDAMNMAVDISVEYNETEKEMNVNLKGDDMGILIGKRGQTLDSLQYLVSLVVNKSSSDYIRVKLDTENYRERRKETLETLAKNIAYKVKRTKRSVSLEPMNPYERRIIHAALQNDKYVVTRSDGEEPFRHVIISLKRENRRDRNDRSDRNEK
What is the function of this protein?
A probable RNA chaperone.  Forms a complex with KhpA which binds to cellular RNA and controls its expression.  Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
What are the official names of this protein?
RNA-binding protein KhpB, RNA-binding protein EloR.
What is the protein family that this protein belongs to?
Belongs to the KhpB RNA-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_RICRS
Sequence: MSEILELEAESRTEFGTGAARALRRAGRVPAIIYGAGKTPVSISLEEKEITKYYRKPAFISQLINLTIDKKKYKVLPKAVELHPVTDIVRHVDFVFLEKKTQKMEVPVVYEGKERALGVKRGGYFNIVKRRVTLLCDVNNIPRNITIDVTNMPMATSLKSSKIELPKGCSFVTKKEFVLATIIGRRGAKTEAEGEQQAAEAGK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: MSHD_ARTS2
Sequence: MSPAHPENWPVLVVKGGVDDELLRDFTALAAAAEESDGNPPLSEQTFVTLRAGESGTHSLLSLALYAPDEESDPATAQDLAGFAVVVEEADGTGVLELAVHPSYRNQGVADRLVATLKASRGFDGLKAWSHGNHEAAADLAAKYGYAPIRELWKMRLTASDAELPDAALPDNVSLRAFIPGQDEEAWLAANKAAFSHHPEQGNMTRQDLAARMAEDWFDPAGFLLAVDPSGRILGFHWTKVHPGHGGHPAIGEVYVVGVTPEAQGMGLGKALTVAGIKYLQDKGLHAVVLYTDADNTPAVSLYRRLGFTRWDADVMYGPKNGG
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: MATK_TSUCA
Sequence: MDEFHRYGKEDSSWQQCFLYPLFFQEDLYAISHDHYLDVSSSSEPMEHLSSNDKLSFLIVKRLIGQIRKQNNSIFLFVNCDPNPLVNHNKSSYSESVLEGLTLVLEVPFSIRSKYSVEGINEWKSFRSIHSIFPFLEDKFPHSNYILDTRIPYSIHPEILVRTFRRWIRDAPSLHPLRSVLYKYRNSPENLKRSIIVVPRVNTRFLLFLWNNYVYECESILVPLLKRSFHPRSSSYGSFPERTHFHRKVKHIIRNFRRNSLKSIWSLKDPKIHYVRYGERPIIAIRGTHLLVKKCRYHLPIFRQCYFHLWSEPYRVCSHQLSKNCSSSLGYSLRVRMKPLLVRTKMLDKLFITDLITDEFDPIVPIVPIIGLLAKEKFCDISGRPISKLSWTSLTDDDILDRFDRIWRNIFHYYSGSFGRDGLYRIKYILSLSCAKTLACKHKSTIRVVRKELGPELFKKYFSKEREFDYPAFSSKAAAHSQRERIWHSDIPQINPLANSWQKIQDLRIERKLI
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LHDAG_HDVV3
Sequence: MSQPDARPGSKAREEALEQWVEERKKKRIAEKELRRINKKIKKLEDENPWLGNIVGMLRKKKDEEGGPPAKRPRREDMEIDSTPGRKSKARGFTDQERRDHRRRKALENKKKQLAGGGKNLSREEEEELRRLARDDDERERRVAGPRPGGVNPMDGPPRGAPGGGFVPSLQGVPESPFSRTGEGIDIRGTQQFPWYGFTPPPPGYYWVPGCTQQ
What is the function of this protein?
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal.  Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding.  Packages the HDV ribonucleoprotein in hepatitis B virus empty particles.  Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg.  May inhibit viral RNA replication (By similarity).
What are the official names of this protein?
Large delta antigen, L-HDAg, p27.
What is the protein family that this protein belongs to?
Belongs to the hepatitis delta antigen family.
What are the subcellular locations of this protein?
Virion. Host nucleus, host nucleolus. Note=isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place (By similarity).
Protein: VEGP1_RAT
Sequence: MKALLLTFGLSLLAALQAQAFPTTEENQDVSGTWYLKAAAWDKEIPDKKFGSVSVTPMKIKTLEGGNLQVKFTVLIAGRCKEMSTVLEKTDEPAKYTAYSGKQVLYIIPSSVEDHYIFYYEGKIHRHHFQIAKLVGRDPEINQEALEDFQSVVRAGGLNPDNIFIPKQSETCPLGSN
What is the function of this protein?
Could play a role in taste reception.  Could be necessary for the concentration and delivery of sapid molecules in the gustatory system.
What are the official names of this protein?
von Ebner gland protein 1, VEG protein 1.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: UBC2_DICDI
Sequence: MSTAARRRLMRDFKRLQSDPPAGISGAPLENNILMWQAVIFGPDDSIWEGATFKLSLQFSEEYPNDAPTVKFLSKMFHPNVYADGSICLDILQNQWSPIYDIAAILTSIQSLLCDPNPNSPANSESARLFRENKREYNRKVKEIVEQSWSS
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 2, E2 ubiquitin-conjugating enzyme 2, Ubiquitin carrier protein ubc2, Ubiquitin-protein ligase ubc2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: CRCB_VIBC3
Sequence: MSFAILGFIALGGAVGACARFLVSEICVTLFGRGFPIGTLTVNVVGSFIMGVLIACVENEWLSPYPWKQVIGLGFLGALTTFSTFSMDNVLLMQQGAFFKMGANVLLNVILSISAAWIGFHWLMKS
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.