PharMolix/UniProtQA huggingface dataset:
Protein: RS14_HAEIE
Sequence: MAKQSMKARDVKRVKLAEKFYAKRVELKKIISDVNASDEDRWDAVLKLQTLPRDSSPSRQRNRCRQTGRPHGVLRKFGLSRIKVREAAMRGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RL17_LIMF3
Sequence: MSYRKLGRTSSQRKALLRDLTTSLIVNGSITTTEPRAKEVRKTMDQMITLAKKGDLASRRKAAAFVRNVVADVKEDGDDIKIQSALQNLFEDIAPKYADRNGGYTRILKTMPRRGDGAKMVILELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RSMH_CUPTR
Sequence: MSPTGTPATPALQHRTVLLDEAVDALVWRPDGVYVDGTFGRGGHSRAVLARLGPDGALVAFDKDPAAIAEAGTIKDARFSIEHASFAAMAERLAGRGHVAGVLLDLGISSPQIDEAARGFSFRFEGPLDMRMDTTRGITAAQWLAQADEQDIARVIRDYGEERFAVQIAKAIVARRSESGDGGPVATTADLAALVAKAVKTREKGQDPATRTFQALRIHVNQELEDLERGLKAAYDLLQVGGRLVVISFHSLEDRIVKRFMAAHARPQQDADPALRRAPLRAADLPQPTLRLLGRYKPGAEEVAANPRARSAVMRVAEKLAPAGGGARA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRC6_LACTC
Sequence: MTTGLSLDEGKVIEGRPKALRDKVLIVFSNKVFNREEILFEVFGVEDNAGKQVHRGVDWTTKYYTVTIDVYVDSFSNLEDWTNEFCDPDFDELRDVIAGWIIVLPFSGNIEEETKALSRLVNNATSEDFFTAILATELNVGKNERAFLEYNVLAGAVELVHNELDSDGELKEVNGVDRVKEIIDTCDWHPRLLRTAHLESETGMESACTGISLAQIMGSLREARTKYMAMDPGLDREEFANEMANELSKLL
What is the function of this protein?
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
What are the official names of this protein?
Increased recombination centers protein 6.
What is the protein family that this protein belongs to?
Belongs to the IRC6 family.
Protein: GPR34_PANPA
Sequence: MRSHTITMTTTSVSSWPYSSHRMRFITNHSDQPPQNFSATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKST
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 34.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UN45B_DANRE
Sequence: MTMGEIGDSVQLKEEGNKHFQAGEIDQAIDCYTKAIKTCKKEDKKALAVIYRNRSACFLKKENYSNAASDATKAIDVDAADIKALYRRCQAFEKLGKLDMAFKDVQRCATIEPKNKTFLETLRRLGAEIQQKLKTTFSTDSRVQNMFDILFSDEPDKEKREKAANNLIVLAREDAGAERIFQNNGVPLLMQLIDTGKPEMILAAIRTLSGMCTGHRARATAIIHSVGISKLCSIMAVDNEEIALATANLFQCVNDSLSGGDKRNYGKEEALVLDSSKDLKDILLALLEMIASKNVSGHGRDQALNLLTKNVPRQNKKSTDNSKCLFTIDHGLKKILKVCGQVPDLPDQLPMTENTQLIASVLLSKLYDDLRCDPERDQFRDICDDYIKSKFDPNDMDKNIHAINTLSGILQGPFDLGNVLAGRQGVMEMMVALCGSEREVDQLVAVEALIHASTKTSKASFFISNGVSLLKEMYKKTKNEKIKIRALVGLCKLGSAGGDDYSMRQFAEGSTEKLAKQCRKWLCNPTLDVRTRKWAIEGLAYLTNDADVKDDFAEDEPAMRAMFELTKSNDKTILYAVACTLVNCTNSYDKKEIIPEMVQLAKFSKQHVPEQHPKDKKDFIVRRVKRLLKAGVTSALAVMVKADNSILTDQTKEMLARVFLALTEDVKDRGIIVAQGGGKALIPLALEGTDKGKIKASHALAKIAAVSNPEIAFPGERIYEVVRPLVSLLGTDRDGMENFEALRGLTNLAGLNDKLRVKILKEKALPEIENYMFEDHEQIRQAATECMCNLVCCKEVQDRYLEDGNDKLKLLVLLCGEDEEKLQRAAAGALAMLTAAQKKLAVKMTKVTEQWLEILQRLCIHDNPEIQHRGLVTVFNMLDADDQLAKKLVESDMLEILTYVAKLEDNPKKQNAIDAARACLSKAMDNGLIKPFSN
What is the function of this protein?
Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity).  Plays a role in sarcomere formation during muscle cell development.  Required for myoseptal integrity, myofiber attachment, motility and craniofacial development (PubMed:17189627, PubMed:17586488, PubMed:20440001, PubMed:20849610).  Is necessary for normal early lens development (PubMed:24549050).
What are the official names of this protein?
Protein unc-45 homolog B, Unc-45B, UNC45-related protein.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere, A band. Cytoplasm, perinuclear region. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage.
Protein: Y382_LISIN
Sequence: MKNLFLTSSFKDVVPLFTEFESNLQGKTVTFIPTASTVEEVVFYVEAGKKALEKLGLFVVELDVATESLDHIAATLRKNDFIYVTGGNTFFLLQELKRTGADKLILEEIAAGKLYIGESAGAVITSPNIAYIQSMDSPKKAEQLTNYDALNLVDFCTLPHYNNIPFKKITQKIVADYTKSLKMHPISNHEAILVRDEEVITKLANGKTD
What are the official names of this protein?
Uncharacterized peptidase Lin0382.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
Protein: NOXA1_MOUSE
Sequence: MSSLGDQIRDWHRGVLAVAREDWDSALCFFSDVREPLARMYFNRGCVHLMAGDPEAALRAFDQAVTKDTCMAVGFLQRGVANFQLQRFQEAVSDFQLALAQLRDNAVIDYTQLGLNFKLQAWEVLYNMASAQCQAGLWTKAANTLVEAISKWPEGAQDILDIAMDKVQKQVPLQLQQVPKGEVFQPPRRYLKHLEPMDFLGKAKVVASVIPDDHNAQPQQRSQAEHAGHQPSSSMCKRVLSTTGGHTSPGLYDSLLASRRPGPGPSEVSSGSEGAATKDPESLVTVTVQCHFTVPLKVPRGTGLSSFQTLLAQALLHQTQTGQLSYKAPGEERSWIPISTEESLQSIWRNVPVGPGGLQLQCQGVWGRPVLYQVVAQYNYRAQRPEDLDFHQGDTVDVLCEVDEAWLEGHRDGCVGIFPKCFVVPAGAYVEAMLVLGPQPGDQN
What is the function of this protein?
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase.  Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction.  May also activate CYBB/gp91phox and NOX3.
What are the official names of this protein?
NADPH oxidase activator 1.
What is the protein family that this protein belongs to?
Belongs to the NCF2/NOXA1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
Protein: CISH_CHICK
Sequence: MILCVPGPHPLLAEEKIQRLSLRGIAEDLTEHIMQPLPVPAFPEEPAPTFAAPEPDGSAPQTRDPEEDLLCIAKTFSYLRESGWYWGSITASEAKQHLQKMPEGTFLVRDSTHPSYLFTLSVKTNRGPTNVRIEYADSKFRLDSNYLSKPRILAFPDVVSLIQHYVTSCTTESKSEAPYPPPAPLPPVQKEVAVAAVHLKLLRPLGRRDSIPSLQHLCRLRINRCTTEVERLPLPRRMGDYLKQYPFQL
What is the function of this protein?
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.  CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor.  Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation.  May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Cytokine-inducible SH2-containing protein, CIS, CIS-1, Suppressor of cytokine signaling, SOCS.
Protein: EFTU_SODGM
Sequence: MSKEKFQRTKPHVNVGTIGHVDHGKTTLTAAITTVLAKAYGGSARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFMNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPVIRGSALKALEGDEAWTAKIIELAEALDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKDTTKTTCTGVEMFRKLLDEGRAGENVGVLLRGTKRDDVERGQVLAKPGSIKPHTQFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVNLIAPIAMDDGLRFAIREGGRTVGAGVVAKVIA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_BIFLO
Sequence: MSRKRPQPPVKPFKKKPNPLKAAKVTEIDYKDVALLRKFISDRGKIRSRRITGVTVQEQRELSKAIKNAREMALLPYATSGR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: QUEC_METMA
Sequence: MKAITLLSSGLDSVAALAIAAESLEIEMAITFDYGQRAGQREMEYSEKVCEHFGIEQRIIKLDWLGEITHTSLVNRDEEVPSLSFEDIDENSPSMITEYSAKAVWVPNRNGVMLNIAGSFAESRGCDYIVVGFNGEEAGTFPDNSRDYIQAVDNAFSYSTQNGVKVLAPLAEMGKTEIVKKALEAEAPLEYSWSCYHGGEIPCGKCESCVRRARAFKNIGIKDPLLERLGI
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, Archaeosine biosynthesis protein QueC, PreQ(0) synthase.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RL2_ACIBY
Sequence: MPIQKCKPTSPGRRFVEKVVHDHLHKGAPYAPLVEAKKRTGGRNNNGHITTRHVGGGHKQHYRIVDFKRNKDGVPAVVERIEYDPNRTAHIALLKYADGERRYIIAPKGLRAGDKVQSGNDAPIRPGNCLPLRNMPIGSTLHNVELKIGKGAQLARSAGASVQLLGRDGSYAIIRLRSGEMRKVHVECRAVIGEVSNQENNLRSLGKAGAARWRGVRPTVRGMAMNPIDHPHGGGEGRNKGIQPVSPWGQKAKGYKTRTNKRTTKMIIRDRRVK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: LV136_HUMAN
Sequence: MAWSPLFLTLITHCAGSWAQSVLTQPPSVSEAPRQRVTISCSGSSSNIGNNAVNWYQQLPGKAPKLLIYYDDLLPSGVSDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNG
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
What are the official names of this protein?
Immunoglobulin lambda variable 1-36.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: CHB4_BOMMO
Sequence: IGCGRGCGGRGYGGLGYGGLGYGGLGYGGLGGGCGRGFSGGGLPVATASAAPTGLGIASENRYEGTVGVCGNLPFLGTAAVAGEFPTVGIGEILYGCGNGAVGITREGGLGYGAGYGGGYGLGYGGYGGGYGLGYGGYGGCGCGCGY
What is the function of this protein?
This protein is one of many from the eggshell of the silk moth.
What are the official names of this protein?
Chorion class B protein B.L1, 410.
What is the protein family that this protein belongs to?
Belongs to the chorion protein family.
Protein: PUR5_GEOMG
Sequence: MGAKGITYKDAGVDIDAGNTFVKMIKPFVRATSRPEVISDIGGFGGLFSLNTNKYKNPVLVSGTDGVGTKLKIAMMADRHDTVGIDLVAMCVNDIVVQGAEPLFFLDYFATGSLSPERGAAVVKGISEGCIQAGCALIGGETAEMPGFYQDGEYDLAGFTVGVVDRDKIIDGSSITVGNTLIGLASSGLHSNGYSLARKIIFDTLGFGINDMLPGHDRSVADELLTPTRIYVKSVLNLLRDFRVNGIAHITGGGLLENVPRILPKGCKAIIRRDSWTMPEIFRILQNGGNMEWTEMYRTFNCGIGMVLAVPENDVDEVLIRLSGLQEKAFVIGEVAKCEAGTESVEMI
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MHPB_ECO5E
Sequence: MHAYLHCLSHSPLVGYVDPAQEVLDEVNGVIASARERIAAFSPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPVELAEACAHAVMKSGIDLAVSYCMQVDHGFAQPLEFLLGGLDKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFTSTLNKRVLFLGSGGLSHQPPVPELAKADAHMRDRLLGSGKDLPASERELRQQRVISAAEKFVEDQRTLHPLNPIWDNQFMTLLEQGRIQELDAVSNEELSAIAGKSTHEIKTWVAAFAAISAFGNWRSEGRYYRPIPEWIAGFGSLSARTEN
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: YEBG_BACSU
Sequence: MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKKENGSIQIVPCGKKIVFEGKLI
What are the official names of this protein?
Uncharacterized protein YebG.
Protein: Y464_SYNE7
Sequence: MAGKGFGFSLGKMKELADAFKKAQQVQEGAKQVQEDLNNMEIEGQAQGGLVKVWVSGNQEPLRAEIAPEALNEGAEVLSELVAAAMKDAYQKSTAAMKEKMEALTAGLGIPGL
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Synpcc7942_0464.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ACP_AYWBP
Sequence: MIFEKIKDLIATQLSLDTSTITLDTRFKEDLGLDSLDALELVMEAEKTFQINISDATLQNFKTVQDIVFYITKNTS
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S35A4_XENTR
Sequence: MYSVNIEPDGSNHSPSRKRLKQILWGLMLVLSVTIYGSHAPLIYLCKVNGEIPFSSSAVVLLIELSKFVISLVFFLIQDWKSLKASVSWHLAAPYAVPAVLYGANNNLVVYIQHFMDPSSFQVLSNLKIVSTAVLYSLFLRQRLSVRRWLSVFLLLAAGVFYSYGGIQDLEKVSSDTNLYVTLPGLLLMLAYCLISGLSAVYTEMTLKTQKIPLNMQNLYLYSFGIIINLTAHLTSSKNSDFFDGFSVWVWVIILSQALNGLIMSLVMKLSNNITRLFIISFSMLANGFLSFILFQLQLTALFFLAVVLIGLAVYMYYGMK
What is the function of this protein?
Mediates the transport of CDP-ribitol (By similarity).  Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (By similarity).
What are the official names of this protein?
Probable UDP-sugar transporter protein SLC35A4, Solute carrier family 35 member A4.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: IHFB_THISH
Sequence: MTKSELIEILARKQSHLAYKDVELSVKTMLEHLSQALATGDRIEIRGFGSFSLHFRPPRVGRNPKTGETVSLPGKYVPHFKPGKELRERVNAVHEQ
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: KAD_LIMRJ
Sequence: MNLVLMGLPGAGKGTQAQKIVENFPIPHISTGDIFRAAMKNETPMGIEAKKYIDKGELVPDEVTNGIVKERLAQDDTKDGFMLDGFPRNLNQAAALDEMLAESNRHLDAVINIHVEPDVLVERLSGRFICRNCGATYHKLYNAPKVEGTCDVCGHHEFYQRDDDKPETVKNRLDVNIKLNTPLVDYYQKKGVLHEINGEQDIDKVYEDIKKVLTNLN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_THET2
Sequence: MREVLILLIRFYRRFLSPLKPRTCRFHPTCSAYALEALERHGAFWGSYLAVRRVLRCHPWNPGGLDPVPVLFPPGKVRGGAE
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ORTB_UNKP
Sequence: MAKDTSYDAVMDRRAEIMSRALGLNYDEFIISDIAFDYEGMMAKAGYSLEEVRQIQSESGVGNTPLLELRNITDLARKTSKRGFGARILIKDEAANPSGSFKDRRASVSIHHAKKLGYPGVLAATSGNYGAAVASQAAMKNLGCIIVQEVFDSRHVGQPEIIEKSRKCEAYGAEVVQLTVGPELFYVSLILLEETGYFNASLYSPFGISGVETLGYELVEQIRARYDKDPAYIVVTHAGGGNVTGTARGALKAGAKNSTIIGASVDLSGLHMASDNDFNKKSFTTGHTGFGVPFATWPDRTDVPKNAARPLRYLDRYVTVTQGEVFYVTEALAQVEGMERGPAGNTSLAAAIALARELPEDEIVVVQETEYTGAGKHPWAQLDFAKQNGIAVKRGAPKENKPGKTIVIPQNFSQITATEMDLNRMRRSYIRNALERNKVKNVTEEDIRFLAEDTKTDADFVTSVIRDLGVRL
What is the function of this protein?
Involved in the ornithine fermentation pathway.  Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine.  It is strictly specific for AKP.
What are the official names of this protein?
2-amino-4-ketopentanoate thiolase beta subunit, AKP thiolase, AKPT.
What is the protein family that this protein belongs to?
Belongs to the threonine synthase family.
Protein: AA1R_RAT
Sequence: MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
What are the official names of this protein?
Adenosine receptor A1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: QUEF_RHIL3
Sequence: MPNTDVSSLSMLGQQTETAQSPEEAVLEKVPSNHAGTDYVVRFTAPEFTSLCPMTGQPDFAHIVIDYIPGEWLVESKSLKLFLHSFRNHGAFHEDCSIYIAKRIVELLDPRWLRIGAYWYPRGGIPIDVFWQTGKPPEGVWLPEQGVATYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDAC5_PONAB
Sequence: MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQLLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSSNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEALLGEGALTMPREGSTESESTQEDLEEEDEEEDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSTWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKVDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWIGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C.  During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity).  Serves as a corepressor of RARA and causes its deacetylation (By similarity).  In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity).
What are the official names of this protein?
Histone deacetylase 5, HD5.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1 (By similarity).
Protein: ARGI_ASHGO
Sequence: MAQRNCWRRSWLGVGGGLCLGAHGAARGPRQLFHLTAKQSSAASDAKCRRWRAAGRGGGAGGVYNGRGAAAGSRQTSGMAHNEHPHYKFFESKKASLVMAPFSGGQGKSGVEDGPKYLLKQGLREGVEGLGWEIEVQRPLDGHDFEERKQRATEVVGRAKNPTLVGEATHLIHDAVRAAAHAGRLPVTLGGDHSIAIGTVSGVLDRYPDAGLLWVDAHADINTLASTESGNLHGCPVSFLMGLERESWPAPLAWVPGTLRPSKIAYIGLRDVDPEEKEILRRLGITAFSMYHVDRYGINKVVEMALAAINPDGTGPVMVSYDVDAIDPMYVPATGTPVRGGLTLREGLFIVERVAETGNLVALDVVECNPELAAHDLHVVDTVQTGCSIARCALGETLL
What are the official names of this protein?
Arginase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
What are the subcellular locations of this protein?
Cytoplasm.