PharMolix/UniProtQA huggingface dataset:
Protein: MLTF_SACD2
Sequence: MTKILLNTASTVLTRLWKLSLLGLVFAVAAATLVSSRIPTTLEEVKSSGKLIVISRNGPTTYYEGPAGHTGFEYVMAKAFAKHLGVDLEVREIEDLGEMLDKVGTKAGHLAASGLTVTEKRARKVLFAEPYLQVTQQLIYRSGESKPETIEDLYGKRVMVISNSSHSERLKELQREYRDLAWEEQHDVDMLDLLEMVHNGKIDYTIVDSNAYQINRPVYPKATVAFDISEPQDLAWAFPQQKDASLYNEAQKFFKDIKQTGAIDDAMETFYGHLGEIDYSGAILFAHRLQSRLPKWETHLKAAAEKNDLDWQLLAALSYQESHWNPKAKSPTGVRGFMMLTLNTAKEVGVKNRLNAEQSIYGGARYFKSLHGRLPERIKEPDRTWLALAAYNIGLGHLEDARILTEHFGGNPDKWADVKQQLPLLAKRKYYKFTKHGYARGWEAVDYVQNIRNFHTIIAWNEIENQRLQQLAQNENHVSDYAQFSPTVTEAVKSISGTSSL
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: PHK_BRADU
Sequence: MKVGRNMTNQQQSAAASSDLDLLDRYWRAANYLSVGQIYLLDNPLLREPLRAEHIKPRLLGHWGTTPGLNFIYAHLNRVIRALDLNVLYVCGPGHGGPGMVANTYLEGSYSEIYPNIARDADGLRKLFRQFSFPGGIPSHAAPETPGSIHEGGELGYALVHAYGAALDNPDLVVACVVGDGEAETGPLAASWHSNKFLNPAHDGAVLPILHLNGYKIANPTVLGRMSDSEIRDLFRGFGHEPLFVEGDDPKLMHRIMADALDVAFASIRSIQQHARDGRKNIERPRWPMIVLRSPKGWTGPKEVDGKKVEGFWRAHQVPVASCRENPAHLKVLEDWMRSYEPEKLFDASGALVPELQALAPEGNRRMGANPHANGGLLKKELKLPDFRSFAVEVPQPGAVTGEATRELGRFLRDVIRLNAQERNFRIMGPDETASNRLDAVFETTERVWMEPIEPYDVHLAQDGRVMEVLSEHLCQGWLEGYLLTGRHGFFSCYEAFIHIVDSMFNQHAKWLKVTRHLPWRRPIASLNYLLTSHVWRQDHNGFSHQDPGFVDLVANKKADIVRIYFPPDANTLLWIADHCLRTYNRINVIVAGKQPAPQWLSMQDAATHCDVGIGIWTWAGTEDAGGEPDVVMACAGDVPTLETLAAVDLLRKALPDLNIRVVNVVDLMTLQPQDQHPHGLSDRDFDSLFTRDKPVIFAYHGYPHLIHRLTYNRTNHAGLHVRGFAEEGTTTTPFDMVVLNELDRYHLAIEAIERVPGLATRAAQVKQQLRDKLLEHSRYVREHGEDMPEIRDWVWPGKPG
What are the official names of this protein?
Probable phosphoketolase.
What is the protein family that this protein belongs to?
Belongs to the XFP family.
Protein: BIOB_BACP2
Sequence: MGKPITLSWEAITEKALKNERITLQEGLDILEADDRELLSIMHAAYQVRFHFFQNKVKLNMIFNAKSGYCPENCGYCSQSIISNAPVERYTMLDQKTIVAGAREALKRKAGTYCIVASGRAPSHRELDEVTAAVKEITETMPLKVCACLGLLNEDKAKRLKEAGVHRYNHNINTHQDHHPHITTTHTYHDRLSTLKKVKQSGMSPCSGVIIGMGETNQQIVEMAFALRAIDADSIPVNFLHAIEGTPLEHQERTHPIKALKVLALMRFVNPTKEIRVSGGREFNLRTLQPLALYAANSIFVGDYLTTKGQQVQTDHHIIEDLGFDIEECAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: PUR7_NITOC
Sequence: MATKKQSELYSGKAKTVYITDDPTQLILYFRDDTSAFDGKKIERFSRKGEINNKFNAFIMEKLAAAGIPTHFERLLSEQESLVKRLEMFPIECVVRNIATGSLCRRLGVQDGLDLDPPVFEFFLKDDARHDPMINEYHIRTFGWANPKQVEQMKEYTFRINDILKVLFLEAGLLLVDYKLEFGDVQGQVLLGDEFTPDGCRLWDVKTREKLDKDRFRHGLGGVTEAYEEVARRLGMSL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RS12_BACC2
Sequence: MPTINQLVRNGRTDKVWKSKSPALNKGFNSLKKKSTDISAPQKRGVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTAGVDKRMQGRSKYGTKRPKPAKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RNPH_ECO57
Sequence: MRPAGRSNNQVRPVTLTRNYTKHAEGSVLVEFGDTKVLCTASIEEGVPRFLKGQGQGWITAEYGMLPRSTHTRNAREAAKGKQGGRTMEIQRLIARALRAAVDLKALGEFTITLDCDVLQADGGTRTASITGACVALADALQKLVENGKLKTNPMKGMVAAVSVGIVNGEAVCDLEYVEDSAAETDMNVVMTEDGRIIEVQGTAEGEPFTHEELLTLLALARGGIESIVATQKAALAN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RL32_SULIA
Sequence: MTEEKIQSYRKKIYVIRQKLKAKKPRFLRYDSDKFFRLGRQEKWRRPYGRDNKTRLKVRGFPAIVSVGYRLPKEVRGFHPSGLRQVIVHNVNDLVKVQNQKDSVIVTIASSVGFKKRLEILNKARELGLKVSNEGVSA
What are the official names of this protein?
50S ribosomal protein L32e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
Protein: UNG_VACCW
Sequence: MNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDYSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEIINVLLELDNKAPINWAQGFIY
What is the function of this protein?
Plays an essential role in viral replication as a component of the DNA polymerase processivity factor (PubMed:17605817, PubMed:20861259).  Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (PubMed:21572084).
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
Protein: NNMT_MOUSE
Sequence: MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAVKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGAFDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVSLPPADCLLSTLCLDAACPDLPAYRTALRNLGSLLKPGGFLVMVDALKSSYYMIGEQKFSSLPLGWETVRDAVEEAGYTIEQFEVISQNYSSTTSNNEGLFSLVGRKPGRSE
What is the function of this protein?
Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:26168293, PubMed:29483571).  Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases (By similarity).  Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3.  In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (By similarity).  Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis (PubMed:24717514, PubMed:26168293).  In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (PubMed:24717514).  Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (PubMed:26168293).  Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (By similarity).
What are the official names of this protein?
Nicotinamide N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSP_PROJR
Sequence: VIGGDECNINEHRFLVALYDF
What is the function of this protein?
Thrombin-like snake venom serine protease that has fibrinogen-clotting activity (217 NIH units/mg).  It releases fibrinopeptide A and a small amount of fibrinopeptide B from fibrinogen alpha (FGA) and beta (FGB).
What are the official names of this protein?
Thrombin-like enzyme jerdonobin, SVTLE, Fibrinogen-clotting enzyme, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TPPC1_HUMAN
Sequence: MTVHNLYLFDRNGVCLHYSEWHRKKQAGIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGIKVVMNTDLGVGPIRDVLHHIYSALYVELVVKNPLCPLGQTVQSELFRSRLDSYVRSLPFFSARAG
What is the function of this protein?
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
What are the official names of this protein?
Trafficking protein particle complex subunit 1, BET5 homolog, Multiple myeloma protein 2, MUM-2.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. BET5 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
Protein: RK16_CICAR
Sequence: MLSPKKTRFRKQHRGRMKGKACRGNKICFGKYALQALEPAWITSRQIEAGRRAMSRNVRRGGQIWIRIFPDKPVTVRPTETRMGSGKGSPEYWVAVIKPGKILYEMGGVAENIARKAISLAASKMPIRTQFILLEESHN
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RRP36_SCHPO
Sequence: MKSSSLENGTLANAGVYEDDLDSDEELVSEEEFENFNNEDSEDDEDSNNESKTAKSQLAEIPFDTLLNAQRDLLKEQQKTKIDRKNMKHTEKVDKKFLAKERNTPLKNCQVKNQFLVFAKFDSLSGNLSKDKVKKNYGFLNEYRVSEIQQLRDELKICKDQERAESIRQTLKSLLSKMERHLEEERAERVMHEFRAQEKERVKEGKKPFYLKRNEQKKLIQMDKYKSMEGTKALDKYIEKKRRRRAQKEKKHLPRARPSANSQNK
What is the function of this protein?
Component of the 90S pre-ribosome involved in the maturation of rRNAs.  Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
What are the official names of this protein?
rRNA biogenesis protein rrp36, Ribosomal RNA-processing protein 36.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NU1C_PHAVU
Sequence: MIIDLTEIQDIHFFFRLEFFKEIYEILWVFVPILIFIVGITISVLAIVWLEREISAGIQQRIGPEYTGPFGVLQALADGTKLLFKENLIPSRGDIRLFSFGPAISVISIILSYSVIPFGYNFVLSDLNIGVFLWIAISSIAPIGLLMSGYGSNNKYSFLGGLRAAAQSISYEIPLTLCVLSISLLSNSLSTVDIVDAQSKYGFWGWNLWRQPMGFLVFLISSLAECERLPFDLPEAEEELIAGYQTEYSGIKFGLFYVASYLNLLVSSLFVTVLYLGGSNISIPYIFVSNFFEINKTYGVFVTIIGIFITLVKTFLFIFVSITTRWTLPRLRIDQLLNLGWKFLLPISLGNLLLTTSSQLFSL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic, NAD(P)H dehydrogenase subunit 1, NDH subunit 1, NADH-plastoquinone oxidoreductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RHMD_SALPA
Sequence: MENIMTLPKIKHVRAWFIGGATAEKGAGGGDYHDQGGNHWIDDHIATPMSKYRDYEQSRQSFGINVLGTLIVEVEAENGQTGFAVSTAGEMGCFIVEKHLNRFIEGKCVSDIKLIHDQMLGATMYYSGSGGLVMNTISCVDLALWDLFGKVVGLPVYKLLGGAVRDEIQFYATGARPDLAKEMGFIGGKMPAHWGPHDGDAGIRKDAAMVADMREKCGPDFWLMLDCWMSQDVNYATKLAHACAPFNLKWIEECLPPQQYEGYRELKRNAPAGMMVTSGEHHGTLQSFRTLAETGIDIMQPDVGWCGGLTTLVEIAALAKSRGQLVVPHGSSVYSHHAVITFTNTPFSEFLMTSPDCSTLRPQFDPILLDEPVPVNGRIHKSVLDKPGFGVELNRDCHLKRPYSH
What is the function of this protein?
Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).
What are the official names of this protein?
L-rhamnonate dehydratase, RhamD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
Protein: FA20C_MOUSE
Sequence: MKMILVRRFRVLILVVFLLACALHIAVDLLPKLDRRATRSSGEPGCSCAQPAAEAAGPGWAQARSRPGESAGGDAGWPNKHTLRILQDFSSDPASNLTSHSLEKLPSAAEPVDHAPRGQEPRSPPPRDPAHRPLLRDPGPRPRVPPPGPSGDGSLLAKLFEHPLYQGAVPPLTEDDVLFNVNSDIRFNPKAAENPDWPHEGAEGAEFLPTGEAAVNLYPNWLKFHIGINRYELYSRHNPAIDALLRDLGSQKITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMINMTKEIRDVTRDKKLWRTFFVSPANNICFYGECSYYCSTEHALCGRPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSGHRILDIMDMTVFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILAPLHQCCRIRRSTYLRLQLLAKEEHKLSLLMAESLQHDKVAPVLYQLHLEALDRRLRIVLQAVRDCVEKDGLSSVVEDDLATEHRASTER
What is the function of this protein?
Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22900076, PubMed:22732358, PubMed:25789606).  Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (By similarity).  Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (By similarity).  Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding (By similarity).  During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone (By similarity).  This is critical to maintain ER proteostasis and reduce cell death under ER stress (By similarity).  Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response (By similarity).  Required for osteoblast differentiation and mineralization (By similarity).  Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:25789606).  In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (By similarity).
What are the official names of this protein?
Extracellular serine/threonine protein kinase FAM20C, Dentin matrix protein 4, DMP-4, Golgi-enriched fraction casein kinase, GEF-CK.
What is the protein family that this protein belongs to?
Belongs to the FAM20 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Endoplasmic reticulum. Note=Resides in the Golgi apparatus membrane and is secreted following propeptide cleavage. Retained in the endoplasmic reticulum (ER) in response to ER stress where it phosphorylates P4HB.
Protein: Y245_TREPA
Sequence: MLQGRCLPLAGGVFALVLSLDSSGRRFWVACSCAPYQHKRRVHTVGGLLSDPHNFARACALFREFSAREERSGVVRAELKCPVDVRDSFLRASREIDPRAAHSLQQEEVLGDGRAALCSADCLLLQAFTHFHNTELARYRARLADIDARIVYERFLRDWECAVACAHFGIHRRSTVFTRVHSDAIRDLEEQRAALALETPESFFVLHAAQWLGEVERVSSGVFAQTPSVSAALERIATSLARGDAVLLRGHLGTGKTELAVLAAERFALHKLITEDVRCALNEWCTAATGGSCAEIRGSERGVSDALQNSQEARTQFQRLFSQRAAYYEQALRLGDERLLQRIKPLFISGSKHIDTEDLFLEKTLVLKNSLEGKTPEHCYQDVHAFTERGYAFDPMLDIYLAKYGNFGTEVQKIEREVLRAVKEGRPLVIDEINAIPMQHLIALNDILQKRVGDFAYIPGVGPVKIAAGFGVIATGNISSGLVHYEGTGALNPAFASRFNTFEYDYPPQSTEGLYTNQAHPEKNELFRIILARLASSGGSLCLPDIDGSLDKLFKLAQLAKVTQQVFSGKWKDSTGGSETHDGLGDVEPELREAVLSIRNVIRVLDEWNRGEEKDVDQALWDGFIGGVLNADDQNYILSQAVRFGFFQEKDGWSVRPKGIGAGFTSYEEIRTRPYEYTRLPDGVKTLAEVVVLLFGHGPTYAMHTQNTVPDVVDAGAMLVLHDRIHELVRVCAAFRLLQEKSYARECADRIAHLQCSCDQLVSEHARLRSEGGTPRALWDDLARAEQTSDALIQELLPEFRHCFPDICGDECTYSDVFFEFGKSITAAIPLAEDSVLIAGGTDDIRLLYRVHDQWLVAESTHKSVKTDWRICALISMGDGEVVVVTEGGETIVLSIQERSKKAERRRVSFEVVARVEGVYERVLCVEKVNAHRVVVGDETGALFILEKSAHGYEYRGPILGLGGGIRVVRALNTAQLVVFSGFSGTRLLHNEEYSDAIYGFENPYTEAVVLSEDRVVVFGDDGESRVLRHEHGMAAGDYAYGEWITGFKSVVLCALALSSRMVLVFGRGGEARLLSFDATGTAQYSRSFGNTTGAVVSAFLLQSEHPSVFNVFIAAENGTCRLLTVHEFCEPSMFKERLSKIVAPPLHDNE
What are the official names of this protein?
Uncharacterized protein TP_0245.
Protein: Y2341_ARCFU
Sequence: MLAIKNTVYEVVETPKYITMYESYQNREKSYRMKIASATGWRKDAIKNLMKKLKIQEKTDDVEKAMRIYVAIKVLNSMKRAEQRYKLVDTVLNLPPEEVFFWA
What are the official names of this protein?
Uncharacterized protein AF_2341.
Protein: YR651_MIMIV
Sequence: MESGEHDSETMYEPYIPPIINKVNTILRSHCRQCVLDLIFKKIKEENVHCYGDYVRYMLIGYDSNRIRVRFKSEFQATFFRKQLEIYLSVKNYGDYEDSNCSTMRVRPKYSNKYFRNFILSNEYIMKLFEQIHQSRTSYLLNKLRKQFKKTRFYLEFYYETSLNYTNYEYIPVNCDFDVDTLMVDKQIYEKPNPEDFIVINPKCKVENVINNINNMQFIILTKNGSPLIQHYSEDIVTGNYDDDYYKFYLDELMGRSHCIDRYSASGKRILSRKEIMEDEGWVCINLPCPNQNCVLFENTIGICCDNDETVSSNSLNMVNFGPDDKNSATNPTHLSKESQNNSESNSESITESPLNSFIQRSGNREDSEISQDNDTVQIDKSTSSDSVHNYFDNSVDNSVHDSVHDSVDTIGQTRRDNASTNRPLYSEYDNFLRTTMDTIKTVYQKKIFDGDSDKIKHSRFSVNQIYDRVEYTDNHDCHDHHDSEISTNNIFG
What are the official names of this protein?
Uncharacterized protein R651.
What is the protein family that this protein belongs to?
Belongs to the mimivirus R69 family.
Protein: DNAJ_HALSA
Sequence: MSEDFYDVLGVSRDATEDEIMQAYRDQVSEYHPDVSDDPDAEEKFKKIQKAKDVLTDEETRQQYDQLGHERFEEAEKRGATGNGGGGAGGMGGAGGPFGGGMGGGAGGGMGDIFEQFFGGAGGGGGRGRSGPEQGRDLRTDLTVTLSEAYRGVSKQVTVRRPESCADCGGSGYPEDADVRTCPQCDGQGVVTQVRQTPLGRVQQRQECSRCGGEGELHSETCSTCGGQGQTRERATLTVDIPEGIRTGQTLRMDGEGAPGEPGAPNGDLLVDVTVEEHPDFERDGDDLHHRHAVSFPQAVFGAEIEVPTLDGAATFDLDAGTQSGETFRLKGKGMPRLRRRGNGDLYVTVQVVTPESLSDEQRDALEQFAEAGGEEIDVEQGFFEKLKNSF
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DFB22_MOUSE
Sequence: MKSLLSTLVIIMFLAHLVTGGWYVKKCANTLGNCRKMCRDGEKQTEPATSKCPIGKLCCVLDFKISGHCGGGGQNSDNLVTAGGDEGSSAKASTAAMVGAAAMAGTPTKTSAPAKTSAPAKTSTTTKASNAAKASTTTKASNAAKASAATMAGNTTKVSTAAIASTPAQASTPTKANST
What is the function of this protein?
Probable component of sperm glycocalyx.  Likely protects and facilitates transport of sperm in the female reproductive tract.  Probably released from the sperm surface during capacitation.
What are the official names of this protein?
Beta-defensin 22, Defb22.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted, extracellular space. Note=In the corpus epididymis, located in vesicles below the apical surface of the plasma membrane. Secreted by epididymal cells and absorbed to the surface of sperm during transit through the epididymis. Coats the entire surface of ejaculated sperm although presence on the equatorial segment is less intense.
Protein: SYP_BORA1
Sequence: MRASNYHINTLKEAPADAEVASHQLMTRAGMIRKLAGGIYSYMPLGLKVIRKVEHIIREEMNASGAIELLMPVVQPAELWQESGRWEQYGQELLRIKDRHQRDFVLQPTSEEVITDIARNEIHSYRQLPVNFFHIQTKFRDERRPRFGVMRGREFTMKDAYSFDRDEAGAGRSYDIMFDAYHRIFRRLGLAFRAVAADTGSIGGSRSHEFQVIADTGEDLLVFNPDSDYAANIELAEAVSLLTERARPAEALQEVATPGAAKCEAVAELLGLPLSQTVKSIVLATESEKDGVQIWLVLLRGDHELNEVKVGKVPGLQNFRLATEAEIVEHFGCKPGYLGPIATAKPVRIIADRTVANMADFVCGANRPDFHLRGVNWGRDLPEPELVTDLRNVVAGDPSPDGKGTLAIQRGIEVGHVFFLGTKYSEALKATFLDETGKPALMQMGCYGIGVTRIVGAAIEQNFDNRGIIWPRAIAPFEVVICPVGWGKSETVRNKSEALYQALREQGIDVILDDRDARPGVMFAEWELIGVPLRVTIGDRGLNDGVIELQGRRDTETVKISVDSALKEILNKLETL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_CLOB1
Sequence: MANIKSAKKRIKVIETKTLRNKMLKSSLKTTIKNFLTVVEGKNVEEAKAAYKTAARALDMSVSKGIVHKNKAARTKSRLAAKLNALNA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: GSHAB_STRT2
Sequence: MTLNQLLQKLEATSPILQANFGIERESLRVDRQGQLVHTPHPSCLGARSFHPYIQTDFCEFQMELITPVAKSTTEARRFLGAITDVAGRSIATDEVLWPLSMPPRLKAEEIQVAQLENDFERHYRNYLAEKYGTKLQAISGIHYNMELGKDLVEALFQESDQTDMIAFKNALYLKLAQNYLRYRWVITYLFGASPIAEQGFFDQEVPEPMRSFRNSDHGYVNKEEIQVSFVSLEDYVSAIETYIEQGDLIAEKEFYSAVRFRGQKVNRSFLDKGITYLEFRNFDLNPFERIGISQTTMDTVHLLILAFLWLDSPENVDQALAQGHALNEKIALSHPLEPLPSEAKTQDIVTALDQLVQHFGLGDYHQDLVKQVKAAFADPNQTLSAQLLPYIKDKSLAEFALNKALAYHDYDWTAHYALKGYEEMELSTQMLLFDAIQKGIHFEILDEQDQFLKLWHQDHVEYVKNGNMTSKDNYVVPLAMANKTVTKKILADASFPVPSGDEFTSLEEGLAYYPLIKDKQIVVKPKSTNFGLGISIFQEPASLDNYQKALEIAFAEDTSVLVEEFIPGTEYRFFILDGRCEAVLLRVAANVIGDGKHTIRELVAQKNANPLRGRDHRSPLEIIELGDIEQLMLAQQGYTPDDILPEGKKVNLRRNSNISTGGDSIDVTETMDSSYQELAAAMATSMGAWACGVDLIIPDETQIATKENPHCTCIELNFNPSMYMHTYCAEGPGQAITTKILDKLFPEIVAGQT
What is the function of this protein?
Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.
What are the official names of this protein?
Glutathione biosynthesis bifunctional protein GshAB, Gamma-GCS-GS, GCS-GS.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.
Protein: FLGD_YEREN
Sequence: MAITNSLTDSDYGINSTTGTSSTTGSSSQDLQNSFLTLLVAQLKNQD
What is the function of this protein?
Required for flagellar hook formation.  May act as a scaffolding protein.
What are the official names of this protein?
Basal-body rod modification protein FlgD.
What is the protein family that this protein belongs to?
Belongs to the FlgD family.