PharMolix/UniProtQA huggingface dataset:
Protein: PETG_ILLOL
Sequence: MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SMG8_DROWI
Sequence: MIMDYHSWVYPNIPEDANRQLLKLGDSLVVVGVLGRSRNRHANKMQAFDMKPNSSNYQPIEGQILCYFTPGTSTLFLHFETPWDEVILSKLLLEEKDPEKFDFDQFYETTRNRFIRHMTLALHVCHILVYVETAQIFDMKLVTIFQLLKQVREQQIMQFAPQLLAELPLVGRGVKCRLCTPRILFLFENYPHDEEKTKETISAYEFQTEDSIYQLLRHHNIVTNSSSSSLLALPNNKQFVFYNAYEDLHPDRLLQAIDSLNRAIQKTDLKEDEEDLEILELSPFEGFVKPFGEFPVSRAILLNPKDEEEQYKKDHTAWHFLQRHVQDALQNCFDEGSFKQGSPQGQQFQRLNINDWHKWMDNLYKILIANVANSNYETNNEDYRVYLRNFDQSLNYERKFWLHLCELGLKKGISCYKHSVPAFYGQETHDKLLAEAILAFEEEGRGPPSEATRAKLSAICLKYWQDGRQQCEQLSLRRHPCTQAKEAPHEKHASGIIHVSSCNCGRTQGRREDPFTLRQANYEFYEYMAQICNLCVKVKQYQFPIFEPSVSDYRAAAFEAAFPLLHGGKPNAEGGEQAAGACEEDEQLTNGCSQPLSATFGSDLNMSIGDFDSLLEGSQVEEPEISYGSADEDDEESLSNTNESLSENTENELVLQFKGPQKAANNDDELDETETIVQSSGGYSNSTTEYLPGLVHTFSNPSLLPMFPSWSLACVGPSSIYSHNTGLQEHFQSGFLSGANFLLPWDVHVRLVQAQKNQHHLQQMGKKHLQRYRKSHLSGGDRLTLKIFVGFEYECSRGHRFMMCSPERVLRGGADIERDTSHKVVHQNMPLYYPCPCRSQSNYLAQLMRIHVVTPKAPVNIILDPRVCVGQYTFTLGTVSPPRLSQSAYWMLRLPYVYQGDDNLLTPPQKLEADDILSGGYLLAGMFGVAETEANATSAPTLDTPATANFMRI
What is the function of this protein?
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity).
What are the official names of this protein?
Nonsense-mediated mRNA decay factor SMG8, Protein smg-8 homolog.
What is the protein family that this protein belongs to?
Belongs to the SMG8 family.
Protein: PYRD_CUPPJ
Sequence: MLNALYPLFRPALFSMDAEDAHHFTLNNLLRAQRLGLGGCIGNRIAEDPRTVMGVRFPNPVGLAAGLDKDGAYIDGLASFGFGFIEVGTVTPRAQPGNPRPRMFRLPQADALINRMGFNNGGVDAFIANVKASRWKAEGGVLGLNIGKNADTPIERAADDYLYCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAPDLDADQIGNIGDALVRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEQSTHVVRALRQVVGDAVPIIGVGGIFSGADARAKIDAGAKLVQVYSGLIYRGPTLVRDCAAALRA
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FIS_ECO45
Sequence: MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: NADK_VIBCH
Sequence: MKKPFNVLAIIGKPRDQQAIQTHKEIYHWLRSLGYTVFIDDRLREILTDLPTEHFASLIELGKKADLAIVVGGDGNMLGAARVLSRFDISVIGVNRGNLGFLTDLNPEDFQQRLQEVLDGHYLQETRFLLEAEIHRHGQVKSHNAALNEAVLHPGKIAHMIEFEVYIDDNFAFSQRSDGLIVSTPTGSTAYSLSGGGPILSPSLNAITLVPMFPHTLSCRPLVVGGNQRIKLVVSPENRGTQEVSCDGQVSLPVSPGDEIHIYQSPNVLKLIHPQDYSYYHVLRTKLGWSSKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_SYNS3
Sequence: MAVARSSRSAAATPRSGAEIRAAFLSFYEERGHKVMASASLIPEDPTVLLTIAGMLPFKPVFLGQQKRPAPRATSSQKCIRTNDIENVGRTARHHTFFEMLGNFSFGDYFKQQAIEWAWELSTDLFGIDPKHLVVSVFREDDEAEQIWRDVVGVNPKRIIRMDEADNFWASGPTGPCGPCSEIYYDFNPELGDEGIDLEDDDRFIEFYNLVFMQYNRDAEGTLTPLANRNIDTGLGLERMAQILQKVPNNYETDLIFPLIQAAADLAGVDYHQLDDAGQTSLKVIGDHSRAVTQLICDGVSASNLGRGYILRRLLRRVVRHGRLLGIHQPFLVTMGQASIALLKDAYPSVIERQEVILAELQREESRFLETLERGEKLLADVLESKPKQISGAQAFELYDTYGFPLELTQEIAEEHGLDVDLAGFEQAMEQQRQRAKAAAVSIDLTLQDAIDQVAADLNATSFEGYDLLVQSSSTVQALLVNGEAAASASDGDVVQVVLDNTPFYGEGGGQVGDRGLLVGDGPDGNGLIVVIEGVSRNRGVFVHSGRVQLGRLGVGDVVHGQVDRACRRRAQANHTATHLLQAALKQVVDEGIGQAGSLVNFERLRFDFHCPRAVKPEELEQIETLINGWISDAQSLEVNEMAIDQAKAAGAVAMFGEKYADVVRVVDVPGVSMELCGGTHVGNTAEIGLFKIVSESGVAAGIRRIEAVAGASVLAYLNEREVVVKQLGDRFKAQPGEIVERVVALQEELKNSQKALTAARSELAVAKSAALAVQAVAVGKHQLLVARLDGVNGDGLQGAALGLLDQLGDATAVVLGGLPDPSDQGKVILVAAFGKAVIATGQQAGKFIGAIAKLCGGGGGGRPNLAQAGGRDGAALDAALNTARAELKKTLG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEGS_SALNS
Sequence: MANFPASLLILNGKSADNQPLREAITLLRDEGIQIHVRVTWEKGDAQRYVDEARRLGVETVIAGGGDGTINEVSTALILIRDGVAPALGLLPLGTANDFATSAGIPEALDKALKLAIAGNAMEIDMARVNDKTCFINMATGGFGTRITTETPEKLKAALGGVSYLIHGLMRMDTLTPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPTALINDGLLQLRIFTGEELLPALFSTLTQSDDNPNIIDGASAWFDIHAPHEITFNLDGEPLSGQEFHIEVLPGALRCRLPPDCPLLR
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_ENCCU
Sequence: MGRRPGRCYRYLSKKAYPKSRFNRGVPDSKIQIFDLGRRKAGVLEFPLLVNCISNERENLSAEALEAARICANKYMVKHAGKDNFHLRIRVYPFHVLRINKMLSCAGADRLQTGMRGSFGKPYGRAARVVFNQPILSIRTKESFRDAAVEALRRAKNKFPGHQKIQVSSKFGFTNMFSDEFNKLNESGRIILRGGSFSVIREKGSIDKFKRDLEYAANN
What are the official names of this protein?
60S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: UGPA_SALCH
Sequence: MSSFRPVFRSRWLPYLLVAPQLVITVIFFIWPAGEALWYSLQSVDPFGFSSQFVGLENFVALFHDSYYLDAFWTTIKFSALVTFSGLLVSLFFAALVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLGEFGYDWNHAQNSGQAMFLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFRLSLPLIAPVSFFLLVVNLVYAFFDTFPVIDAATAGGPVQATTTLIYKIYREGFTGLDLSASAAQSVVLMFLVIILTVVQFRYVESKVRYQ
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpA.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TPCG_ASPFU
Sequence: MPYAVLGATGNCGTALIQNLLQSSTSKVHAYCRDRRKLLYLLPHLADNKQVDIFDGSIHDLPLITECVRNCHAVFLVISTNDNVPQCRMALDTATAVIQALRILHGEGASMPKLVLLSSATLDDQLSQNTAPWVRWILLKSASQVYQDLSQAEAFLRQQQDWISTIFIKPGGLSVDVQRGHRLSLTEEKSPLSYLDLAAAMIEAADDPDGRYDLRNVGVAYTDGPARFPRGAPMCIFMGLVRHFLPFLHPYLPATGPNQGFLC
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process (PubMed:26278536, PubMed:26242966).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC (PubMed:26242966).  The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC (PubMed:26242966).  The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone (PubMed:26242966).  The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin (PubMed:26242966).  Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:26242966).  Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (By similarity).  Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH.  Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin (PubMed:26242966).  Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death (PubMed:22319557).  The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway (PubMed:26242966).
What are the official names of this protein?
Oxidoreductase tpcG, Trypacidin synthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the avfA family.
Protein: RLMKL_FRATM
Sequence: MQKFTFFVSCAKGIELLLKDELERLGISSQEKLAGVEFEGSIKDAYKVCIYSYLASQVMLKVATDKVINQQDLYEFISSINWMDYFAVDKTFKIIISGKHYDFNNTMFVSQKTKDAIVDQFRNVTNQRPNIDTENPDNVIKLHLHKQFVNVFLCLNIDSLHKRSYRQFQGQAPLKESLAAAILIKAGWLEELKKHQPILIDPMCGSGTILIEAALMAKNIAPVLLNKEFKIFNSKFHNQELWDNLLEIAKNSQKVTNAIICGFDIDNNVLDKAQRNIYQAGVEDVVTVKCQDIRDLENEFESEGLIVTNPPYGERLYGDQLDELLDIFNGFGDRLSQDFYGWKVAVLTSFADSIKELQLRTTERNKFYNGAIETILYQFEINEHAQFKHETQLEKNIRIAEASAQKSDEHIDFANKLKKNLKSLKPWLKQTGFECYRLYDADIPTFAVAVDVYSEHIFLQEYRADATIDQNIAKQRFYQAIYQIHKTLDIKYENIHTRVRQRQKGKEQYQKENDKNKFHIINEFDAKFYVNFDDYLDTGIFLDHRKIRQLVAKAAKNKTLLNLFSYTCTASVHAALKGAKTTSVDMSNTYLEWGKNNFTLNNINAKKHSFIQADCISWLKTNKDKFDVIFLDPPTFSNSKRMDDILDIQRDHELLINLAMDSLKKDGILYFSNNYRRFKMSPQILEKFNCENIDKICLSRDFLSNKNIHNCWEIKYK
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1C_TUPAK
Sequence: MRLAPIKLVVNYYVLFGKSLNQEKENLIEMKGVITQCLSNGMFRVKLENGFKVIAHISGKIRRNFIRILLGDSVIVELSPYDLTRGRIIYRLKPTNSSTETLRFNTNLK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MYO1_ARATH
Sequence: MSQKVTPFMQSLKSLPADYRFDGSPVSDRLENSSGASVRLTNSNVPRKGGLRNGVSRTDTAAGDSEDSPYSGHGVFVEEQSLTDDVDSGAATMPLPQSDERRWSDTSAYARKKILQSWIQLPNGNWELGKILSTSGEESVISLPEGKVIKVISETLVPANPDILDGVDDLMQLSYLNEPSVLYNLNYRYNQDMIYTKAGPVLVAVNPFKEVPLYGNRYIEAYRKKSNESPHVYAIADTAIREMIRDEVNQSIIISGESGAGKTETAKIAMQYLAALGGGSGIEYEILKTNPILEAFGNAKTLRNDNSSRFGKLIEIHFSESGKISGAQIQTFLLEKSRVVQCAEGERSYHIFYQLCAGASPALREKLNLTSAHEYKYLGQSNCYSINGVDDAERFHTVKEALDIVHVSKEDQESVFAMLAAVLWLGNVSFTVIDNENHVEPVADESLSTVAKLIGCNINELTLTLSKRNMRVRNDTIVQKLTLPQAIDARDALAKSIYSCLFDWLVEQINKSLAVGKRRTGRSISILDIYGFESFDKNSFEQFCINYANERLQQHFNRHLFKLEQEEYIQDGIDWTRVDFEDNQNCLSLFEKKPLGLLSLLDEESTFPNGTDLTLANKLKQHLQSNSCFRGDKGKLFTVVHYAGEVTYETTGFLEKNRDLLHSDSIQLLSSCSCLLPQAFASSMLIQSEKPVVGPLYKAGGADSQRLSVATKFKSQLFQLMQRLGNTTPHFIRCIKPNNIQSPGVYEQGLVLQQLRCCGVLEVVRISRSGFPTRMSHQKFSRRYGFLLVENIADRDPLSVSVAILHQFNILPEMYQVGYTKLFFRTGQIGVLEDTRNRTLHGILRVQSSFRGYQARCLLKELKRGISILQSFVRGEKIRKEFAELRRRHKAAATIQSQVKSKIARIQYKGIADASVVIQSAIRGWLVRRCSGDIGWLKSGGAKTNELGEVLVKASVLSELQRRVLKAEAALREKEEENDILQQRLQQYENRWSEYETKMKSMEEIWQKQMRSLQSSLSIAKKSLAVEDSARNSDASVNASDATDWDSSSNQFRSQTSNGVGSRLQPMSAGLSVIGRLAEEFEQRAQVFGDDAKFLVEVKSGQVEANLDPDRELRRLKQMFETWKKDYGGRLRETKLILSKLGSEESSGSMEKVKRKWWGRRNSTRY
What is the function of this protein?
Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation.  Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables (By similarity).  Involved in endocytosis via its action in endosomal trafficking.
What are the official names of this protein?
Myosin-1, AtATM1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Plant myosin class VIII subfamily.
What are the subcellular locations of this protein?
Cell junction, plasmodesma. Cytoplasm, cytoskeleton, phragmoplast. Endosome. Endoplasmic reticulum.
Protein: RL21_ACIBT
Sequence: MYAVIQSGGKQHRVVEGETLKVELLKAESGATITFDDVLMVVNGDNIQIGAPVVAGAKVTAEVIGHGRHDKIRIIKMRRRKHYRKQQGHRQWFTELKITGISG
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: UREG_SINMW
Sequence: MPSKNGPLRVGIGGPVGSGKTALTEKLCKAMRERYSLAVVTNDIYTKEDAEALVRMQALPSERIVGVETGGCPHTAIREDASINLQAIADLNRRLPELDLVFIESGGDNLAATFSPDLADLTIYVISVCQGEEIPRKGGPGITKSDLLVINKKDLAPHVGADLEIMERDAARMRGEKPFVFSDMKRGDGVERIVDFLILHGGL
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_PSEPF
Sequence: MQNQQIRIRLKAFDHRLIDQSTQEIVETAKRTGAQVRGPIPLPTRKERFTVLVSPHVNKDARDQYEIRTHKRVLDIVQPTDKTVDALMKLDLAAGVEVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PROX_SALTY
Sequence: MRHTVIFASAFATLVTASAFAADLPGKGITVQPIQSTISEETFQTLLVSRALEKLGYTVNKPSEVDYNVGYTSIASGDATFTAVNWQPLHDDMYAAAGGDNKFYREGVFVSGAAQGYLIDKKTAEQYNITNIAQLKDPKIAKIFDTNGDGKADMMGCSPGWGCEAVINHQNKAFDLQKTVEVSHGNYAAMMADTITRFKEGKPVLYYTWTPYWVSDVMKPGKDVVWLQVPFSSLPGEQKNIDTKLPNGANYGFPVNTMHIVANKAWAEKNPAAAKLFAIMKLPLADINAQNAMMHAGKSSEADVQGHVDGWINAHQQQFDGWVKEALAAQK
What is the function of this protein?
Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake.  Binds glycine betaine and proline betaine with high affinity.
What are the official names of this protein?
Glycine betaine/proline betaine-binding periplasmic protein, GBBP.
What are the subcellular locations of this protein?
Periplasm.
Protein: SHF_HUMAN
Sequence: MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL
What is the function of this protein?
Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.
What are the official names of this protein?
SH2 domain-containing adapter protein F.
Protein: SYI_BUCAP
Sequence: MNDYKNTLNLPKTQFSMRANLSQKEPKILKNWYDNNLYKLIRQKKEGKKIFFLHDGPPYANGNIHIGHAVNKILKDIIIKSKNMSGFDAPYIPSWDCHGLPIEQKVEEQMGLKSNNIITTIFQKKCRKYAEKQIKKQKKDFIRLGVIGDWENAHLTMDFKNEANIIKTLSKIIEKKYLYKESKPIHWCLKCYSSLSDAEIEHFDKESDSIFVAIKSKNNKILKEVLNLNISSEKDIYLPIWTTTPWTLPSSQAITVNPIFEYQIIETKKYNLILAKELVKNVMKILEINHWNILSSFKGKILEGKKFLHPFLENISLPVILGDHVNLDSGTGAVHTAPDHGPDDYIVSQKYKIKTMNLVDFKGNYINNIHPKLNGVNIFQANEIIINLLIKKDCLLHHNILKHSYPHCWRHKTPVIFRATEQWFINIDQKKLRYKTLEEIKKVSWIPKWGGSRIEEMIKKRPDWCVSRQRKWGVPMCLFLHKKTGKIHPENTLLIKKIIKKVELEGIEAWWKINLKEMLGETYNMYNQTFDILDVWFESGNTHTVIKYKNKKYSKNHADMFLEGSDQHRGWFMSSLIISMLVKNQSPYSEVLTHGFVVDKNGQKMSKSIGNTISPNEVVKTLGGDILRLWVASSNYSNDISISNEILKRSSDIYRRIRNTARFMLANINDFNPQKNTVLKENMVLLDRWAISQAKIVQEEIIEFYKKYNFHAIIKRLMYFCSIEMGSFYLDIIKDRQYTLKTNSQERRSCQTAIYYIINALVRWIAPILSFTADEIWNHLPGKHAQYVFTEEWFNKLFDLDKNDLFNREFWKNLIEMKNEINKFLETEIKNKNINNSLEACLILYVTPEVKKTLNILGEELKFIFLTSKVKIELYNTAPINSTKSKKISNFKIFLKKIKEKKCPRCWHYNIFIENNNDKICTRCILNTKGNGEKRFFI
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_STRA1
Sequence: MKIIAKKDLFINDEIRVREVRLVGLEGEQLGIKPLSEAQAIADDANVDLVLIQPQATPPVAKIMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPVIDKGDFETKLRNGRKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEATQDIAIIEQRAKMDGRQMFMQLAPIPDKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_BUCAT
Sequence: MNFEVLYQDNNARCGVFNFNQEIIETPVFMPVGTYGAVKSISTEEIKNTGSRIILSNAFHLYFRPGLEIIKLHGNLHNFMNWSGPILTDSGGFQVFSLSRFCKINEEGVIFQNHIDGKKTFLTPKISMKIQSDLGSNIVMIFDQCIEYNQNWEKTKNAMERSLYWAKKSRIYFDSYKNKNSLFGIIHGGIYPSLRDISLQELIKIDFDGYALGGLAVGEPKIEMYKLLDHICPQIPKNKPRYLMGVGKPEDLIEGVRRGVDMFDCVIPTRNARNGHLFVTNGVIKIRNKKYKKDLSCLDNTCACYTCRYYSRSYLHHLDACNEILGARLNTIHNLHYYQTLMSNIRNSIKNNTFEQFSLNFYKQKNKIDF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: GSHB_VIBCH
Sequence: MIKLGIVMDPIASINIKKDSSFAMMLEAQRRGYEIHYMEMNDLHLEQGVALADTKVVELKEDPSGWYQFKSEQTIALSELDAILMRKDPPFDTEYIYATYILERAEDEGVLVVNKPQSLRDCNEKLFTAWFPELTPITMVTRKAEKIKAFREQHGDVILKPLDGMGGASIFRVKEGDPNLSVIIETLTNHGQNYCMAQTFVPDISNGDKRILVVDGEPMPYCLARIPAKGETRGNLAAGGRGEPRPLSETDKKIALAVAPTLKEKGLLFVGLDVIGDKLTEINVTSPTCIREIEAAYDISITGKLMDAIERRLKATAM
What are the official names of this protein?
Glutathione synthetase, GSH synthetase, GSH-S, GSHase, Glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic GSH synthase family.
Protein: TORD_SALBC
Sequence: MQHSSVTSPRAAIYQWFSQLLFQELTEAQLVTLGGRESRAWIASLSTIPGLASDVKRFERSLTRVLHREAREQELAADFASLFLLAPPVGVSPYAGHYPHTTPAQERRQMNALLVEQALAPRENEASDHIAIQLALMAEQISREASVATQYYFLQHHILCWAPLFMASCQQREAEGFYVLAVAMIVHFMHEDAQYLESLLMDNVYCRNH
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMO_SHEB8
Sequence: MTVETFKPKQTTTLDIPVKTLEAASTNAVTTGNRIGFVSLGCPKNLVDSERILTQLRIDGYEVTNSYDNADLVIVNTCGFIDAAVEESLDAVREALEENGKVIVTGCLGAKENQIREVHPDVLEITGPHSYEAVLKHVHKYVPKPEHNPFTSLIPQTGVKLTPKHYAYLKISEGCDNRCTFCIIPSLRGDLDSRPAGSILDEAKRLVESGVQEILVVSQDTSAYGKDKGGRTDFWNGMPVKQDITSLARQLGKMGAWVRLHYIYPYPWVDDLIPLMAEGLILPYLDIPMQHASPRILKMMKRPGRVDRQLEAIQRWREICPDLVIRSTFIVGFPGETEEDFQILLDFLKEARLDRVGCFKYSEVDGAVANTIAELISEDVKEDRYHRFMEVQAEISAERLARFVGRTLDILIDDVDEEGAIGRSFADAPEIDGMVFINGETELEPGMLVRARITHSDEHDLWAEVVDADTQD
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGLA_ECOLI
Sequence: MIVKKLTLPKDFLWGGAVAAHQVEGGWNKGGKGPSICDVLTGGAHGVPREITKEVLPGKYYPNHEAVDFYGHYKEDIKLFAEMGFKCFRTSIAWTRIFPKGDEAQPNEEGLKFYDDMFDELLKYNIEPVITLSHFEMPLHLVQQYGSWTNRKVVDFFVRFAEVVFERYKHKVKYWMTFNEINNQRNWRAPLFGYCCSGVVYTEHENPEETMYQVLHHQFVASALAVKAARRINPEMKVGCMLAMVPLYPYSCNPDDVMFAQESMRERYVFTDVQLRGYYPSYVLNEWERRGFNIKMEDGDLDVLREGTCDYLGFSYYMTNAVKAEGGTGDAISGFEGSVPNPYVKASDWGWQIDPVGLRYALCELYERYQRPLFIVENGFGAYDKVEEDGSINDDYRIDYLRAHIEEMKKAVTYDGVDLMGYTPWGCIDCVSFTTGQYSKRYGFIYVNKHDDGTGDMSRSRKKSFNWYKEVIASNGEKL
What is the function of this protein?
Catalyzes the hydrolysis of phosphorylated beta-glucosides into glucose-6-phosphate (G-6-P) and aglycone.  It has a high affinity for phosphorylated aromatic beta-glucosides (p-nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin), with the exception of phosphorylated salicin, and a low affinity for phosphorylated beta-methyl-glucoside.  Apparently, it has only a very limited role in the utilization of external beta-glucosides.
What are the official names of this protein?
6-phospho-beta-glucosidase BglA, Phospho-beta-glucosidase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.