PharMolix/UniProtQA huggingface dataset:
Protein: PPTA_EMENI
Sequence: MVQDTSSASTSPILTRWYIDTRPLTASTAALPLLETLQPADQISVQKYYHLKDKHMSLASNLLKYLFVHRNCRIPWSSIVISRTPDPHRRPCYIPPSGSQEDSFKDGYTGINVEFNVSHQASMVAIAGTAFTPNSGGDSKLKPEVGIDITCVNERQGRNGEERSLESLRQYIDIFSEVFSTAEMANIRRLDGVSSSSLSADRLVDYGYRLFYTYWALKEAYIKMTGEALLAPWLRELEFSNVVAPAAVAESGDSAGDFGEPYTGVRTTLYKNLVEDVRIEVAALGGDYLFATAARGGGIGASSRPGGGPDGSGIRSQDPWRPFKKLDIERDIQPCATGVCNCLS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of an acyl-carrier-protein.  The enzyme is able to transfer the cofactor to a broad range of enzymes with acyl- or peptidyl-carrier protein domains.  Required for primary biological processes such as growth and asexual/sexual development, and activates target enzymes involved in the synthesis of metabolites such as fatty acids, polyketides and nonribosomal peptides, lysine, siderophore, penicillin, sterigmatocystin, shamixantone, dehydroaustinol, and pigments.
What are the official names of this protein?
4'-phosphopantetheinyl transferase NpgA, PPTase.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily.
Protein: CCME_CAUSK
Sequence: MNFLPKSRKARRRLTILAVAAPVVALAVGLALWGMRDAISLFYTPAQAAAAHVPAGRKVQLGGLVKAGSVVKHPDGLVEFVVADQRSTALVHYKGDLPDLFREGQGIVASGAFDESGTFVANQVLAKHDERYMPREVAKALKEQGEWRGDGQAPSYQGYKPGKPNT
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: RS20_CALBD
Sequence: MANTKSAKKKIKVIRRRTIENKIQKFKMKKAIKEVKKALLSGDIEKAKELYSKAAKLIDQTAAKGVIHKNNASRKKSRLMKLINKYAALSSPQPESKAQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: HTPG_BACFN
Sequence: MQKGNIGVTTENIFPIIKKFLYSDHEIFLRELVSNAVDATQKLNTLASISEFKGELGDLTVHVSLGKDTITISDRGIGLTAEEIDKYINQIAFSGANDFLEKYKNDANAIIGHFGLGFYSAFMVSKKVEIITKSYKEGAQAVKWTCDGSPEFTLEEVEKADRGTDIVLYIDDDCKEFLEESRISALLKKYCSFLPVPIAFGKKKEWKDGKQVETAEDNVINDTIPLWTKKPSELSDEDYKKFYRELYPMSDEPLFWIHLNVDYPFHLTGILYFPKVKSNIDLNKNKIQLYCNQVYVTDSVEGIVPDFLTLLHGVLDSPDIPLNVSRSYLQSDSNVKKISTYISKKVSDRLQSIFKNDRAQFEEKWNDLKIFINYGMLTQEDFYDKAQKFALFTDTDGKHYTFEEYQTLIKDNQTDKDKNLIYLYANNKDEQFAYIEAAKNKGYNVLLMDGQLDVAMVSMLEQKLEKSRFTRVDSDVVDNLIVKEDKKSDVLEASKQEALSAAFKSQLPKMEKVEFNVMTQALGENGSPVMITQSEYMRRMKEMANIQAGMSFYGEMPDMFNLVLNSDHKLVKEVLADEEKECSAAIAPIQTELEDVTKRRDALKKKQEGKKDEDIPTAEKDELNDLDKKWDELKQQKDSIFAGYAGKNKVVRQLIDLALLQNNMLKGEALNNFVKRSIELI
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP4R2_DICDI
Sequence: MTLVEYSETLKKSLEEFCKQDKKVVTPELNSIIENISKTGITCYPWNILKELFYFKLNEILDIFEKEYIATSSTTTTSTTTTTTNTSSSSTNSPQSPQSPQSPQLNVNIKDEEMQKIKNQVNLSGLIKMKKEFLDSFKESKLSPFTVQRLCELIINYKMYTSFSKYLCAVEKMLNVSTLPHLTPEEVIEFNKNQNSGSRLNSSTNTTTTTTTTTTTTTPTEKGNNDQPNLDSFAFSSSFTTSFPSDTTSSTSTSLSTDQEMKDLDVEQQKDDTDNTANENESK
What is the function of this protein?
Probable regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 regulatory subunit 2.
What is the protein family that this protein belongs to?
Belongs to the PPP4R2 family.
Protein: YBJQ_ECOSM
Sequence: MQFSTTPTLEGQTIVEYCGVVTGEAILGANIFRDFFAGIRDIVGGRSGAYEKELRKAREIAFEELGDQARALGADAVVGIDIDYETVGQNGSMLMVSVSGTAVKTRR
What are the official names of this protein?
UPF0145 protein YbjQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: EFG_CLOK5
Sequence: MGREYPLEKFRNIGIMAHIDAGKTTTTERILFYTGRTHKIGEVHEGQATMDWMAQEQERGITITSAATFCKWKGYAINIIDTPGHVDFTVEVERSLRVLDGAVTVLDAKSGVEPQTETVWRQADNYGVPRLVYVNKMDSTGADFYMCVNTLRDRLHCNAIPIQIPIGSESEFKGIVNLVKNEAIIYEDDLGTVMDEVEIPGDLKDEAEKYRTELIEAISELDEDIMMKYLEGEELTEEEIISAIRKGVISNKIVPVLCGSSYKNKGVQPMIDAVVDFMPSPLDIPPIKGTDPETGEETDRPADDNQPLSALAFKIATDPFVGKLAFTRIYSGIMKSGTYVYNSTKGKKERIARLVKMHSNRREEVDELRAGDLGAIVGLKDTTTGNTLCDEQNAVVLESMEFPEPVIHVAIEPKTKAGQEKMGIALSKLAEEDPTFKTHTDQETGQTIISGMGELHLEIIVDRLQREFKVECNVGKPQVAYKETIRKTVKAEGKFVRQSGGHGQYGHCWIEMSPSEEGYSFENAIVGGTIPKEYISPIDEGIKQASETGTVAGYPAINFKVKLYDGSYHDVDSSEMAFKIAASMAFKNAMSKADPVLLEPMMRVEVTVPEEYMGDVIGDINSRRGRIEGMDPRAGAQVIRSFVPLSEMFGYATVLRSRTQGRGVYSMTFDHYEEVPKSIQEKITGEKK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_HALOH
Sequence: MNRVAVIHGPNLNLLGRREPEVYGTKSLENINKEIEKRANNLKIEVDIFQSNHEGEIIDFIHDNYKALSGIIINPGGLTHYSIALRDALAAVRLPVVEVHISNIHKREDFRHRSVIASVAVGQITGLGTEGYLYALEAIVNIIKKGSY
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: MKRN4_HUMAN
Sequence: MAEAAAPGTTVTTSGAGAAAAEAAETAEAVSPTPIPTVTAPSPRAGGGVGGSDGSDGSGGRGDSGAYDGSGACGGSDACDGSGDSSGDSWTKQVTCRYFKYGICKEGDNCRYSHDLSDRLCGVVCKYFQRGCCVYGDRCRCEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTNEAESRNSNFATVVAGSEDWANAIEFVPGQPYCGRTVPSCTEAPLQGSVTKEESEEEQTAVETKKQLCPYAAVGQCRYGENCVYLHGDLCDMCGLQVLHPMDAAQRSQHIQACIEAHEKDMEFSFAVQRSKDKVCGICMEVVYEKANPNEHRFGILSNCNHTFCLKCIRKWRSAKEFESRIVKSCPQCRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKACKYFDEGRGSCPFGENCFYKHMYPDGRREEPQRQQVGTSSRNPGQQRNHFWEFFEEGANSNPFDDEEEAVTFELGEMLLML
What is the function of this protein?
May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
What are the official names of this protein?
Putative E3 ubiquitin-protein ligase makorin-4, Makorin RING finger protein pseudogene 4, Makorin RING finger protein pseudogene 5, RING finger protein 64, RING-type E3 ubiquitin transferase makorin-4, Zinc finger protein 127-Xp, ZNF127-Xp, Zinc finger protein 127-like 1.
Protein: ATPG_CUTAK
Sequence: MASNLRELRERRNSVATTKKITRAMELIASSRIIKAQNTVKAAGPYSLELTRALSAVAAHTHEEHPLTSMNPDPKRSAVLVITSDRGLAGAYSSNVIRTAEELTTALQPKQEIATYLCGRKAVQYFEFRGRKVDHLWSGFSDSPSYRDAKDIADHLIEDFLRPTEEGGVDEIHMVYTEFESMLTQTPKVIRLLPLAVVDPQDTPEGQLAEGDPGVGANAEEIFHEYRFEPNPVSVLDELLPLYVANRVHYALLQSAASELASRQRAMKAATDNAEQLIQTLTRQANQARQAAITQEITEIVGGAAALAESAPQE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y1004_LEUCK
Sequence: MTVNIYDNANEMASVLKETEQYTAWQNAFNAIQADEEAKQLFTKFQSVQVAVQQMMQSQQQPSADQEKEWDAIAADVQKNELITALLSTEQALNTLLTEINDIVTKPVADAYAKLRQK
What are the official names of this protein?
UPF0342 protein LCK_01004.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: TCPE2_AVESA
Sequence: MALDFDEYWRPFIILREQEKKSRLQGLDAQKANIAAGKSVARILRTSLGPKGMDKMLQSPDGDVTITNDGATILELMDVDNQIAKLMVELSRSQDYDIGDGTTGVVVMAGSLLEQAEKLLERGIHPIRVAEGYEMASRIAVDHLESISTKYEFSATDIEPLVQTCMTTLSSKIVSRCKRALAEIAVKAVLAVADLERKDVNLDLIKVEGKVGGKLEDTELVQGIIVDKDMSHPQMPKRIEDAHIAILTCPFEPPKPKTKHKVDIDTVEKFQTLRGQEQKYFDEMVQKCKDVGATLVICQWGFDDEANHLLMQRELPAVRWVGGVELELIAIATGGRIVPRFQELSTEKLGKAGLVREKSFGTTKDRMLYIEKCANSKAVTIFIRGGNKMMIEETKRSIHDALCVARNLIINNSIVYGGGSAEISCSIAVEAAADRHPGVEQYAIRAFADALDAIPLALAENSGLPPIDTLTVVKSQHVKENNSRCGIDCNDVGTNDMKEQNVFETLIGKQQQILLATQVVKMILKIDDVITPSEY
What is the function of this protein?
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.  Known to play a role, in vitro, in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit epsilon, TCP-1-epsilon, CCT-epsilon, TCP-K36.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR83_MOUSE
Sequence: MAFPEPKPRAPELPQKRMKTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKPEPVQTLDEARDGISSVKVSDHEILAGSVDGRVRRYDLRMGQVSSDYVGSPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQQYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSNVVQSLAYHPTEPCLLTAMGGSIQYWREETYEAEGGAG
What is the function of this protein?
Molecular scaffold protein for various multimeric protein complexes.  Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3.  May promote degradation of HIF1A.  May act by recruiting signaling complexes to a specific upstream activator (By similarity).  Also acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists.  At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation.  May also be involved in pre-mRNA splicing.
What are the official names of this protein?
WD repeat domain-containing protein 83, Mitogen-activated protein kinase organizer 1, MAPK organizer 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MORG1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Protein: TIG_KORVE
Sequence: MTTEASNPEVNATAEVAVPVNPLLRSVTVEIPSDVVDAERNKHVQQYAKLARVPGFRKGKVPPSVIRTRFAQDINEEIVRTLIPHYFREETGKQNLQPVSQPQVTDLHLHDGEPLKFTAEFEILPEIPTTGYENIKVEHPPVEVTDAEIEDTIKSLQEQRATYDPIEDRAAEDGDFVQISFEGRDKSDPEAKPVEVPSIMVELGGSNTVQEFTENLRGTKAGDEKTFDVVYPADYGDQRLAGKSVEYHVSVKSLKKKIFPELDEAFISELGADVKTPDELRAKIREGAEHEKKHHAEHEGKDKLVDALVKLNDFPVPESMVNSQIEIRLERGLRALAQQGMRTEDMKKMDFGKLREGQREAATREVKASLLLEKIADAEKIEVSDEELDRQIAGLARQSQQSPEQVRARLTQDGSLDRIRTQIRNEKTLDLLYSRSA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: MNME_CARHZ
Sequence: MMEDTIAAISTPLGEGGIGIVRVSGPGAIEAVKNVFIPRQSKDLSKVPSFTLHYGKIVDPADGKIVDEVLVSVMRAPKSYTGEDVVEINCHGGIVAVEKVLELILKQGIRLAEPGEFTKRAFLNGRIDLSQAEAVIDIIRAKTEASLKLAGRQLSGELREKINAVRQKIINILAFIEVSIDYPEYEFDEVTPETALKNIDEIINDVRRLLSSYERGRILREGITAVIAGKPNVGKSSLLNALLRKKRAIVTDIPGTTRDVIEDYLNLKGIPVKIVDTAGIRETEDLVEKLGVEKTREYLNQADVTLFVVDVSIGIDEDDEKILSLINKDKSLLVINKIDLLQGKVNFEQYAVKTGIKNFVPFSARNFEGLEILENKLYEILIPEQEGEGESALISNLRHKNYLEKALNSLLSAKESIASGEPVDLVAIDLNEALRELGAITGDALGDEIINEIFSQFCVGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARF_NEUCR
Sequence: MGNTLSIFGKLFDGLFGKKEMRILMVGLDAAGKTTILYKLKLGEVVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVVEAREELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLSSLRQRSWYIQATCATTGDGLFEGLDWLSTELKKKSP
What is the function of this protein?
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: ORSA_EMENI
Sequence: MAPNHVLFFPQERVTFDAVHDLNVRSKSRRRLQSLLAAASNVVQHWTASLDGLERADIGSFEDLVELAERQTTQTRGSIVADLVLLTTVQIGQLLVLAEDDPAILSGHAGARAIPMGFGAGLVAAGVAAAATSADGIVNLGLEAVSVAFRLGVELQRRGKDIEDSNGPWAQVISSATTIADLEQALDRINASLRPINQAYIGEVMTESTVVFGPPSTLDALAKRPELAHATITSPASALAQVPLHGAHLPPISATMIAASSSQQATELWKLAVEEVANKPIDVHQAVTALIHDLHRANITDIVLTAIGASTETSGIQSLLEKNGLAVELGQLSPTPRPYGNDLDSIPADAIAVVGMSGRFPNSDTLDEFWRLLETATTTHQVIPESRFNVDDFYDPTRAKHNALLARYGCFLKNPGDFDHRLFNISPREAMQMDPVQRMLLMTTYEALEMAGYSPPTPAAPGDSEQAPPRIATYFGQTIDDWKSINDQQGIDTHYLPGVNRGFAPGRLSHFFQWAGGFYSIDTGCSSSATALCLARDALTAGKYDAAVVGGGTLLTAPEWFAGLSQGGFLSPTGACKTYSDSADGYCRGEGVGVVILKRLADAVRSKDNVIAVIAGASRNCNAGAGSITYPGEKAQGALYRRVMRQAAVRPEQVDVVEMHGTGTQAGDRVETHAVQSVFAPSNGNQREKPLIVGALKANIGHSEAAAGIISLMKAILILQHDKIPAQPNQPIKMNPYLEPLIGKQIQLANGQSWTRNGAEPRYIFVNNFDAAGGNVSMLLQDPPAFALPAPASGPGLRTHHVVVTSGRTATAHEANRKRLHAYLSAHPDTNLADLAYTTTARRIHNVHREAYVASSTSDLVRQLEKPLADKVESAPPPAVVFTFTGQGAQSLGMGGALYSTSPTFRRLLDSLQSICEVQGLPTKFLNAIRGSGAEGATVTEVDMQVATVALEIALARYWRSLGIRPTVLIGHSLGEYAALCVAGVLSASDALALAFRRATLIFTRCPPSEAAMLAVGLPMRTVQYRIRDSAATTGCEVCCVNGPSSTVVGGPVAAIQALDEYLKSDGKVSTTRLRVQHAFHTRQMDVLLDELEASAAQVPFHAPTLPVASTVLGRIVRPGEQGVFDANYLRRHTREPVAFLDAVRACETEGLIPDRSFAVEIGPHPICISLMATCLQSAKINAWPSLRRGGDDWQSVSSTLAAAHSAQLPVAWSEFHKDHLDTVRLISDLPTYAFDLKTFWHSYKTPAAAVSAASATPSTTGLSRLASTTLHAVEKLQREEGKILGTFTVDLSDPKLAKAICGHVVDESAICPASIFIDMAYTAAVFLEQENGAGAALNTYELSSLEMHSPLVLREDIEVLPQVWVEAVLDIKSNAVSVHFKGQTSKGAVGYGSATMRLGQPDSAVRRDWSRIQSLVRARVQTLNRSVRPREVHAMDTALFYKVFSEIVDYSAPYHAVQEAVIAADFHDAAVTLQLTPTADLGTFTSSPFAVDALVHVAGFLLNADVRRPKNEVHIANHIGSLRIVGDLSSPGPYHVYATIREQDQKAGTSLCDVYTTDSQDRLVAVCSDICFKKLERDFFALLTGATRGRSTKPVAAAPAKSMAKRARQLAPSPSPSSSSGSNTPMSRSPTPSSVSDMVDLGTELLQAVAEQTGVSVAEMKSSPGTTFTEFGVDSQMAISILANFQRTTAVELPAAFFTNFPTPADAEAELGGSALDDLEEDITKPTPSPEQTQARKQGPAPSQHLLSLVAQALGLEASDLTPSTTFDSVGMDSMLSIKITAAFHAKTGIELPAAFFSANPTVGAAQEALDDDAEEESAPAQTSTNPAKETTIDSSRQHKLDAAVSRASYIHLKALPKGRRIYALESPFLEQPELFDLSIEEMATIFLRTIRRIQPHGPYLIGGWSAGSMYAYEVAHRLTREGETIQALIILDMRAPSLIPTSIVTTDFVDKLGTFEGINRARDLPEDLSVKERAHLMATCRALSRYDAPAFPSDRQPKQVAVVWALLGLDNRPDAPIASMGRPGLDIGKSMYEMNLDEFERYFNSWFYGRRQQFGTNGWEDLLGDHIAVYTVNGDHFSMMCPPYASEVGDIVIETVTRAVE
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B (PubMed:19666480, PubMed:20174687).  The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:19666480, PubMed:20174687).  Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B (PubMed:20174687).  The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B (PubMed:20174687).
What are the official names of this protein?
Orsellinic acid synthase, OAS, Non-reducing polyketide synthase orsA, Orsellinic acid/F9775 biosynthesis cluster protein A.
Protein: ACHN3_CARAU
Sequence: MKLQISGLLLVTAVAYATIEAPEEFVSLAEMEDTLLRNLFRGYQKWVRPILHANDTITVRFGLKISQLVDVDEKNHLMTTNVWLWQEWTDYKLRWNPEDYGGITSIRVPSETIWLPDIVLYENADGRFEGSLMTKAIVRFNGTIMWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLTLLDAYVDRKDFFDNGEWEILNATGQRGSRRDGIYSYPYVTYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLLLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTLFVINVHHRSSATYHPMAPWVKSLFLQRLPRLLCMRGHTDRYQYPDIELRSPELKRGMKKGQQKSAGGGRGGLKEDENQAWIALLEKATHSVHYISRHIKKEHFIREVVQDWKFVAQVLDRIFLWVFLTASVLGTILIFTPALHMYLST
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit non-alpha-3, GFN-alpha-3.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: GEP7_CLAL4
Sequence: MSLAMLTRNMLRRTSVRAFASSASNFTAGKDSARKLSPEEAKAEAAKLAIQSLKDVGSVFSSGSDDAVQPIDTRPVFENPELFGTLNLLHQGQVLKELQEKYDKNWNKLTDEEKKLGYYIAYGNWGPREKFINWNTQEAPYDLPFRVPSKVRLSNPQANDVVHKLEPLYLSETPVRKEQFDTSKMDPVTKTFIYITLFVMLFAISRDKNTGESGKPQEIIIEDRYMKSKLEKEQKEKEKEIEEENRKNQEKQARRKWYYLWLK
What is the function of this protein?
Involved in respiratory growth and required for cell survival in the absence of prohibitins.
What are the official names of this protein?
Genetic interactor of prohibitin 7, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the GEP7 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: FABH_RICPR
Sequence: MTCKIIGSGGYLPPKIISNDELTKFVDTNDKWIRTRTGILQRHIAGDAEYTSHLAFKSAQKAIEDAMISVDDIDLIIICTTTPDNSFPSVATKLHGYLGLTNIPSFDLQAVCAGFIYGLQLAHSLIVSGKYKTILLIGAEKMTSLLDWNDRSTCVLFGDGAGSVILQRSNDDSGLIDSNIFSSGTDYEILYTSGGTSMNGTSGKIVMQGQKLFRHAIEKMLQSIEDLLYANQFSVSDIDYFIPHQANIRIINKLAELLNIEEHKVVKTVEKHANCSAASIPLALSALKESGKIKKGDILLFSAIGAGLTWGGALIRW
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTU_SACEN
Sequence: MSSARPVRAARGTTLTARSWSTEAPLRMLQNNLDPEVAERPDDLVVYGGTGKAARNWASFDAIVRELTTLSDDETLLVQSGKPVGVLRTHEWAPRVLLANSNLVGDWANWPEFRRLDALGLMMYGQMTAGSWIYIGTQGILQGTYETFAAVAERRFGGTLAGTLTITAGLGGMGGAQPLAVTMNEGVALVVECDPERAHRRVKHGYLDEVADGLDQAIEKAEAAKAQRRAYSVAVIGNAAEVLPELLRRGVRADIVTDQTSAHDPLSYLPLGVELEDWEDYASKKPEEFTDRARDSMAKHVEAMVGFMDAGAEVFDYGNSLRGEAQLAGYGRAFDYPGFVPAYIRPLFCEGKGPFRWAALSGDPADIAATDRAILDLFGDDDHLARWIRLAGEKVSFQGLPARICWLGYGERHLAGLRFNEMVASGELKAPLVLGRDHLDCGSVASPYRETEGMADGSDAIADWPLLNALVNTASGATWVSLHHGGGVGMGRSLHAGQVTVADGTALAAQKLERVLTNDPGMGVIRHVDAGYDRAREVATERGVRVPGLA
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_RALSO
Sequence: MSTIPITKRGAEMLKDELQRLKTKERPAVVNAIAEARAQGDLSENADYDAAKERQGFIEGRILEIESKLAAAQVIDPAGLDADGRIVFGATIDLEDLDSGKPVTYQIVGDDEADLDSGKISISSPIARALIGKYEGDVATVVAPGGEREYEVRAVKYL
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: TSAD_THENN
Sequence: MRVLGIETSCDETAVAVLDDGKDVIVNFTVSQVEVHRKFGGVVPEVAARHHLKNLPFLLKETFKKVDPQTVDVVAATYGPGLVGALLVGLSAAKGLSISLKRPFVGVNHIEAHVHAVFLANPTLTPPFVVLMVSGGHTQLMKVNEDYSMEILGRTLDDSAGEAFDKVARLLGLGYPGGPIIDEVAKKGDPKKYSFPRPMMDEPNYNFSFAGLKTAVLYFLKKEKDYRVEDVAASFQEAVVDILVEKTFRLARNLGIRKIAFVGGVAANSRLREKVNDRAKRWGYEVFFPPLSLCTDNALMVARAGYEKAKRGIFFPLYLNADPNLSV
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YE046_YEAST
Sequence: MQNIFYRSAYVHTVCPARLEYYLLLPLLLYYYYYYHHHEPDDPNCEAHFSYFTNPSWDTEGLIYTKLFLKSTRPMGLIISLSVSNNLSPRSRSGPMAASFAKDVISLPE
What are the official names of this protein?
Putative uncharacterized protein YER046W-A.