PharMolix/UniProtQA huggingface dataset:
Protein: ATG19_YEAS7
Sequence: MNNSKTNQQMNTSMGYPLTVYDECNKFQLIVPTLDANIMLWCIGQLSLLNDSNGCKHLFWQPNDKSNVRILLNNYDYGHLFKYLQCQRKCSVYIGEGTLKKYNLTISTSFDNFLDLTPSEEKESLCREDAHEDPVSPKAGSEEEISPNSTSNVVVSRECLDNFMKQLLKLEESLNKLELEQKVTNKEPNHRISGTIDIPEDRSELVNFFTELKTVKQLEDVFQRYHDYERLSQECDSKTEIASDHSKKETKIEVEPPNERSLQITMDQRDNSLYFQLFNNTNSVLAGNCKLKFTDAGDKPTTQIIDMGPHEIGIKEYKEYRYFPYALDLEAGSTIEIENQYGEVIFLGKYGSSPMINLRPPSRLSAESLQASQEPFYSFQIDTLPELDDSSIISTSISLSYDGDDNEKALTWEEL
What is the function of this protein?
Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy.  Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole.  Involved in the organization of the preautophagosomal structure (PAS).  ATG19 association with cargo protein is required to localize ATG11 to the PAS.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress.  Also plays a role in regulation of filamentous growth (By similarity).
What are the official names of this protein?
Autophagy-related protein 19, Cytoplasm-to-vacuole targeting protein 19.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Also found in other perivacuolar punctate structures.
Protein: MRAZ_GLUOX
Sequence: MSMFLGTHQNRFDAKGRVSIPASFRAALKSQAQPGDPLVILRPSHLHPCIEGWTVGAFASLATPLDEYDPFSEDHEDLAASLYADAYPLDSDKEGRIILPENLRTHAALTDEVSFMGLGRTFQIWNPEAAAERRQAARSRARTLATSRRPASAPAAGNTAGAAE
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SPEE_HELPG
Sequence: MWITQEITPYLRKEYTIEAKLLDVRSEHNILEIFKSKDFGEIAMLNRQLLFKNFLHIESELLAHMGGCTKKELKEVLIVDGFDLELAHQLFKYDTHIDFVQADEKILDSFISFFPHFHEVKNNKNFTHAKQLLDLDIKKYDLILCLQEPDIHKIDGLKRMLKEDGVFISVAKHPLLEHVSMQNALKNLGDFFAVAMPFVAPLRILSNKGYIYASFKTHPLKDLMAPKIEALTSVRYYNEDIHRAAFALPKNLQEVFKDNIKS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_BACNA
Sequence: MDITFNTGLMGSGKSKKLIDDYLIDPKEKVALSVSLTEDTFSRGKIESRDGRSLRSINLNRDQFKQNISLLEIIIFMTNTQTIYIDESQFLPKETVEKFVSLSESYHVPIHFYGLDLTFTGELFDSSSHLLTILPSENINRISRGCEASKCSKIAQYNARIVDGKVSRSGETFVEEKSYYLALCSDHYYNDEKII
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAT_MYCBO
Sequence: MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT
What are the official names of this protein?
Probable L-lysine-epsilon aminotransferase, L-lysine aminotransferase, Lysine 6-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: NRAM_I67A0
Sequence: MNPNQKIITIGSVSLTIATVCFLMQIAILVTTVTLHFKQHECDSPASNQVMPCEPIIIERNITEIVYLNNTTIEKEICPKVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPVKCYQFALGQGTTLDNKHSNDTVHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLAGSAQHVEECSCYPRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSGLVGDTPRNDDRSSNSNCRNPNNERGTQGVKGWAFDNGNDLWMGRTISKDLRSGYETFKVIGGWSTPNSKSQINRQVIVDSDNRSGYSGIFSVEGKSCINRCFYVELIRGRKQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: HBB_PASMO
Sequence: VQWTAEEKQLITGLWGKVNVAECGGEALARLLIVYPWTQRFFASFGNLSSPTAVLGNPKVQAHGKKVLTSFGEAVKNLDSIKNTFSQLSELHCDKLHVDPENFRLLGDILVVVLAAHFGKDFTPDCQAAWQKLVRVVAHALARKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: DAPD_RHOPS
Sequence: MSLSALENTINTAFDARDTISAATKGEVRDAVDQALDLLDRGEARVAERDASGTWTVNQWLKKAVLLSFRLNDMHTIAGGPGGATWWDKVPSKFEGWGESRFREAGFRAVPGAIVRRSAFIAKNAVLMPSFVNLGAYVDEATMVDTWSTVGSCAQIGKRVHISGGVGIGGVLEPLQAGPVIIEDDCFIGARSEVAEGVIVRRGAVLAMGVFLGASTKIVDRETGEVFIGEVPEYAVLVPGALPGKPLKNGTPGPSTACAVIVKRVDERTRSKTSINELLRD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSA_SALDC
Sequence: MKQKVVNIGDIKVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTFGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVILCDRGANFGYDNLVVDMLGFSVMKKVSGNSPVIFDVTHALQCRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPDPANAKCDGPSALPLAKLEQFLTQIKAIDDLVKSFDELDTEN
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_HAEIG
Sequence: MIDFRPFYQQIATTNLSDWLETLPLQLKEWETQTHGDYAKWSKIVDFLPDLHADEIDLKSAVKSDRTSPLSEGEKQRIIHHLKQLMPWRKGPYHLFGIHVDCEWRSDFKWDRVLPHLAPLQGRTILDVGCGSGYHMWRMVGEGAKMVVGIDPTELFLCQFEAVRKLLNNDRRANLIPLGIEQMQPLAAFDTVFSMGVLYHRKSPLDHLSQLKNQLVKGGELVLETLVVDGDVNTVLVPIDRYAKMKNVYFIPSVAALINWLEKVGFTNVRCVDVATTTLEEQRKTDWLENESLIDFLDPNDHSKTIEGYHAPKRAVILANK
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: RS2_STAAB
Sequence: MAVISMKQLLEAGVHFGHQTRRWNPKMKKYIFTERNGIYIIDLQKTVKKVDEAYNFLKQVSEDGGQVLFVGTKKQAQESVKSEAERAGQFYINQRWLGGLLTNYKTISKRIKRISEIEKMEEDGLFEVLPKKEVVELKKEYDRLIKFLGGIRDMKSMPQALFVVDPRKERNAIAEARKLNIPIVGIVDTNCDPDEIDYVIPANDDAIRAVKLLTAKMADAILEGQQGVSNEEVAAEQNIDLDEKEKSEETEATEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: HEM3_ECODH
Sequence: MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAPA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RLMN_PSEFS
Sequence: MTTSTVKTNLLGLTQPEMEKFFDSIGEKRFRAGQVMKWIHHFGVDDFDAMTNVSKALRDKLKAIAEVRGPEVVSEDISSDGTRKWVVRVASGSCVETVYIPQGKRGTLCVSSQAGCALDCSFCSTGKQGFNSNLTAAEVIGQVWIANKSFGSVPATVDRAITNVVMMGMGEPLLNFDNVIAAMHLMMDDLGYGISKRRVTLSTSGVVPMIDELAKHIDVSLALSLHAPNDALRNQLVPINKKYPLKMLLESCQRYMATLGEKRVLTIEYTMLKDINDKVEHAVEMIELLKNTPCKINLIPFNPFPHSGYERPSNNAIRRFQDQLHQAGYNVTVRTTRGEDIDAACGQLVGQVMDRTRRSERYIAVRELNAADDLPQIAVNRI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMPA_XENLA
Sequence: MGCTRGWRLLLLLGLVCVGALQGRGQEESREVSLQYNPGSSDTSVNVVHVRAVGNGSTIHYVWSTIGTPTVLLIFTHSETSQLQVNWTKLLSPAPQGALRIEPAESVSYATALLFTRIFEYQDVNNTANFSGTDEKYFYPAYNLSDFLWDSANATINATSLSANLTGYNASDPTDSFHNGSVSFRISAYSSSGRDSSSPRLRHTANCTKLEFLVAGVRPRGNNSRFALEMVTIEKEGRKKMESVHSIDDEYTPTIFEMMQLVPDAPNSSHARGFLQWKSVAYGSPSGTRADILPCQLHPLRPFNTTFPAGSIAHAYFGDDLADAYKLEAFNISFGIADGDFYDKNRFLSWSALIGYGEPPRDSFSILVICIMAVALGTPLLLLIVGTLVVTALRHKVYSNYEPIN
What is the function of this protein?
Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.
What are the official names of this protein?
Glycosylated lysosomal membrane protein A, Lysosomal protein NCU-G1-A.
What is the protein family that this protein belongs to?
Belongs to the GLMP family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass type I membrane protein; Lumenal side.
Protein: MTCA2_MYCTO
Sequence: MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV
What is the function of this protein?
Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
What are the official names of this protein?
Carbonic anhydrase 2, Beta-CA 2, Carbonate dehydratase 2, mtCA 2.
What is the protein family that this protein belongs to?
Belongs to the beta-class carbonic anhydrase family.
Protein: YHFA_ECOLI
Sequence: MQARVKWVEGLTFLGESASGHQILMDGNSGDKAPSPMEMVLMAAGGCSAIDVVSILQKGRQDVVDCEVKLTSERREEAPRLFTHINLHFIVTGRDLKDAAVARAVDLSAEKYCSVALMLEKAVNITHSYEVVAA
What are the official names of this protein?
Protein YhfA.
Protein: THIO_CYACA
Sequence: MPSPIQVTDFSFEKEVVNSEKLVLVDFWAPWCGPCRMISPVIDELAQEYVEQVKIVKINTDENPSISAEYGIRSIPTLMLFKDGKRVDTVIGAVPKSTLTNALKKYL
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ES2RA_PELRI
Sequence: GILSLVKGAAKLLGKGLAKEGGKVGLEFIACKVTNQC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Esculentin-2Ra.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Esculentin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPT_BACCR
Sequence: MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQVVKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRVIGQKDRLPTHTRRAMEKAMEDTKENTGLILNFALNYGSRDEIVSAVQHMMKDNEEGKIRSEEVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFKEEHLLNAITDFQHRGRRFGGV
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: HFQ_YERP3
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQVESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNTPSGSTNNYHGSNPSAPQQPQQDSDDAE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: BDNF_EPICE
Sequence: SCMKAAPMKEVSIRGQGSLAYPGLRTQGNLETLSGPNDATRGLTSLADTFEHVIEELLDEQQVIQPSKENKDADLYSTRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCSSKGYAKEGCRGIDKRYWNSQCRTTQSFVRALTMDNKKRVGWRFIRIDTSC
What is the function of this protein?
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y57M_ECOLX
Sequence: MAKGESERIVLEVEPELKKALYSVLAMEQKTLKDWFVDKAQEHICEKKSELIERFSKVDNEI
What are the official names of this protein?
Uncharacterized 7.3 kDa protein in Eco57IM 5'region, ORF S.
Protein: MGSA_GEOKA
Sequence: MKIALIAHDQKKEEMVAFATAYAPVLANHELYATGTTGLRIQEATGLPVHRFQSGPYGGDQEIGAMIARNEMDLVIFFRDPLTAQPHEPDISALMRLCDVYAVPLATNIGTAELLIRALERGDLAWRSIVRGQTKGGEESKTER
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: YWIC_BACSU
Sequence: MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYLAVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMYFARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVKSVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTIGILEIVNACFFLAVMCLFITR
What are the official names of this protein?
Uncharacterized protein YwiC.
What is the protein family that this protein belongs to?
To H.influenzae HI_1626.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TYW4_YEAST
Sequence: MKNLTTIKQTNKNVKQERRKKYADLAIQGTNNSSIASKRSVELLYLPKLSSANNFQMDKNNKLLEYFKFFVPKKIKRSPCINRGYWLRLFAIRSRLNSIIEQTPQDKKIVVVNLGCGYDPLPFQLLDTNNIQSQQYHDRVSFIDIDYSDLLKIKIELIKTIPELSKIIGLSEDKDYVDDSNVDFLTTPKYLARPCDLNDSKMFSTLLNECQLYDPNVVKVFVAEVSLAYMKPERSDSIIEATSKMENSHFIILEQLIPKGPFEPFSKQMLAHFKRNDSPLQSVLKYNTIESQVQRFNKLGFAYVNVGDMFQLWESADEATKKELLKVEPFDELEEFHLFCHHYVLCHATNYKEFAFTQGFLFDRSISEINLTVDEDYQLLECECPINRKFGDVDVAGNDVFYMGGSNPYRVNEILQLSIHYDKIDMKNIEVSSSEVPVARMCHTFTTISRNNQLLLIGGRKAPHQGLSDNWIFDMKTREWSMIKSLSHTRFRHSACSLPDGNVLILGGVTEGPAMLLYNVTEEIFKDVTPKDEFFQNSLVSAGLEFDPVSKQGIILGGGFMDQTTVSDKAIIFKYDAENATEPITVIKKLQHPLFQRYGSQIKYITPRKLLIVGGTSPSGLFDRTNSIISLDPLSETLTSIPISRRIWEDHSLMLAGFSLVSTSMGTIHIIGGGATCYGFGSVTNVGLKLIAIAK
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.  Catalyzes the final 2 independent reactions, methylation of the alpha-carboxy group of wybutosine-72 to form wybutosine-58, and methoxycarbonylation of alpha-amino group of wybutosine-58 through the fixation of CO(2) to complete wybutosine.
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 4, tRNA yW-synthesizing protein 4, tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LCMT family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: VKT1_VIPAA
Sequence: MSSGGLLLLLGLLTLWAELTPVSGQDHPKFCYLPADPGRCKAHIPRFYYDSASNKCNKFIYGGCPGNANNFKTWDECRQTCGASAMGRPT
What is the function of this protein?
Serine protease inhibitor that principally inhibits trypsin (Ki=0. 34 nM).  Also inhibits alpha-chymotrypsin (Ki=270 nM), plasmin, plasma and pancreatic kallikrein.
What are the official names of this protein?
Kunitz-type serine protease inhibitor 1, Venom basic protease inhibitor 1, Venom trypsin inhibitor I, cVamTi.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y162_MYCPN
Sequence: MKLNLRFPSYFLPVVAASAFLVSCATPNTYEVQRAALIQLVEEDERQNYIQKGSMGANAVMTAAKAETKTAEKTATSTKAASIELKKTDTDIKTTTTTENKSASGYKLDTLFGDYILWVVDHLSGLLFSPKTNNSTTTQKIQLITEDKMILDGGNLTVEKNHEHGHTHKNGETHEHDHDHHEGEEEVIVGRALSFANGLFLVVDLKEEKHEEKKEAKSEMSMNSKDMVMMTKTEMMSKEMKSEQKMEKKEEHEHPHKKLSLSTTAYKFGQSFNILEFTGAMHHKTAHNNETEFKNLGKKYGGMTEYTIVDFDFNPPKPTK
What are the official names of this protein?
Uncharacterized lipoprotein MG149 homolog.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: P73_MOUSE
Sequence: MAQTSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGTSEASGSEESNMDVFHLQGMAQFNLLSSAMDQMGSRAAPASPYTPEHAASAPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLAQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILVIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRAFKQSPPAIPALGTNVKKRRHGDEDMFYMHVRGRENFEILMKVKESLELMELVPQPLVDSYRQQQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGVNKLPSVNQLVGQPPPHSSAAGPNLGPMGSGMLNSHGHSMPANGEMNGGHSSQTMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKVPDQYRMTIWRGLQDLKQSHDCGQQLLRSSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGAGAVTGPDEWADFGFDLPDCKSRKQPIKEEFTETESH
What is the function of this protein?
Participates in the apoptotic response to DNA damage.  Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms.  May be a tumor suppressor protein.  Is an activator of FOXJ1 expression, essential for the positive regulation of lung ciliated cell differentiation (PubMed:26947080).
What are the official names of this protein?
Tumor protein p73, p53-like transcription factor, p53-related protein.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.
Protein: ZAPD_ECODH
Sequence: MQTQVLFEHPLNEKMRTWLRIEFLIQQLTVNLPIVDHAGALHFFRNVSELLDVFERGEVRTELLKELDRQQRKLQTWIGVPGVDQSRIEALIQQLKAAGSVLISAPRIGQFLREDRLIALVRQRLSIPGGCCSFDLPTLHIWLHLPQAQRDSQVETWIASLNPLTQALTMVLDLIRQSAPFRKQTSLNGFYQDNGGDADLLRLNLSLDSQLYPQISGHKSRFAIRFMPLDTENGQVPERLDFELACC
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: CH602_COREF
Sequence: MAKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLRNVAAGSNPMGIKRGIEQAVATVTEKLLESAKEVETEEQIAATAGISAADPAIGAQIAKAMYAVGGGKLNKDSVITVEESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLLEKVMQSGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAILTGGQVISEEVGLSLETADLPLLGQARKVVVTKDDTTIVDGAGSEEQIEGRVNQIRAEIENSDSDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALIQAAHVLDNDLDLTGDEATGVRIVRDALTAPLKQIAANAGLEPGVVADKVSRLPEGEGLNAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAMPGADEMGGMGGF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALBA1_ARCFU
Sequence: MAENSVFVGNKPVMNYVLAVLTQFNSGATEVSIKARGRAISRAVDVAEIVRKRFLPDVDVKDIKISTEQIDSEQGTANVSAIEIILAKK
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity).
What are the official names of this protein?
DNA/RNA-binding protein Alba 1, Af2.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.