PharMolix/UniProtQA huggingface dataset:
Protein: RRAAH_MYCLB
Sequence: MIVSFRPTADLVDSIGVDVRSCDLQFRQFGGCSEFAGPISTVRCFQDNALLKSVLSQTSAGGVLVVDGAGSLHTALVGDVIAELAHSNGWAGLIVNGAVRDAAALRGIDIGIKALGTNPRKSTKIGTGERHVEVNLGGVTFVPGEVVYSDDDGIVVV
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: TGTL_PLAFA
Sequence: EFLEKVQIIKNTNLSNSLCILSIPCTVDIDTVITETINKYDSIIDGILLSGLGYDESNETRTNAFKNILNILPNNKLKFIQLSNGNPIEILHAIYHGIDVIEPNFPYYLAKNGKAINMNLKMDNLQDGNEYNLQDKNNDNIYDINLLDFKNDVNFIIDLNNPKYVLDHSTITCNSPRKESKSYIHHLLKCHELTAHVILTYHNLYIYRSFFQEIQLHIKENNFLSYINWFIEKNELNKKEE
What are the official names of this protein?
Queuine tRNA-ribosyltransferase-like protein.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: NU3C_SYNPW
Sequence: MFVLPGYDAFLGFLLIAAAVPVLALVTNKLLAPRSQDGERQLTYESGMEPIGGAWIQFNIRYYMFALVFVIFDVETVFLYPWAVAFHRLGLLAFIEALIFIAILVVALAYAWRKGALEWS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3, NDH-1 subunit 3, NDH-C.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: FABV1_VIBVU
Sequence: MIIKPKIRGFICTTTHPVGCEANVKEQIAYTKAQGPIKNAPKRVLVVGASSGYGLSSRIAAAFGGGAATIGVFFEKEGSEKKPGTAGFYNAAAFEKLAREEGLYAKSLNGDAFSNEAKQKTIDLIKEDLGQVDMVVYSLASPVRKLPETGELIRSALKPIGQTYTSTAVDTNKDIIIEASVEPATEQEIQDTVTVMGGEDWELWINALAEAGVLADGCKTVAYSYIGTELTWPIYWDGALGKAKMDLDRAASALNDKLSATGGSANVAVLKSVVTQASSAIPVMPLYIAMVFKKMREEGVHEGCMEQIYRMFSQRLYKEDGSAAEVDEKNRLRLDDWELRDDIQEHCRNLWPQITTENLKELTDYVEYKEEFLKLFGFGIDGVDYEADVNPDVATDFIAI
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH] 1, ENR 1.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: RL1_PARP8
Sequence: MAKLSKRLQAFASKVDRQKLYAIEEALSLVKECASAKFDESIDVAVQLGIDAKKSDQVVRGSVVLPAGTGKSVRVAVFAQGEKAEQARAAGAEIVGMEDLAEQVKAGNLNFDVVIASPDTMRVVGTLGQILGPRGLMPNPKVGTVTPDVATAVKNAKAGQVQFRVDKAGIIHATIGRASFEPTALRSNLNALVEALQKAKPATSKGVYLRKIALSSTMGVGVRVDQATLAAQ
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: RL18_AFIC5
Sequence: MSKLKITNARRKQRVRIALRRAAGGRPRLSVFRSSKHIYAQVIDDQKGETLASASSLEKTMREGGKTGANIDAAKAVGKLLAERAVKNGVKEVVFDRGGYLYHGRVKALADAARESGLSF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RNFC_YERPN
Sequence: MFKLFTARQHDKIWDFDGGIHPPEMKLQSSTVPMRIAPLPDQLIIPLQQHLGPEGELRVRAGEQVLKGQPLTVGRGRTVPVHAPTSGMITAIAPHTTAHPSGLAELCVHITPDGEDRWREQQPWADYRQRDKMALLDRIHQAGIAGLGGAGFPTASKLQGGLNGIITLIINAAECEPYITADDRLMQEHADEVITGIHILRHLLQPQQVLIGIEDNKPEAIAALQRALRGQDDIHLRVVPTKYPSGGAKQLTKILTGKEVPFGKHSSSIGVLMQNVGTVVAIKRAVIDDEPLIERVVTLTGDALSSPGNFWARIGTPVLYLLKLAGFKPQNPPMVIMGGPLMGFTLPSLDVPIVKISNCILAPAETEMGLSEPEQSCIRCGLCVDACPAGLLPQQLYWFSRGEEHEKARNHNLFDCIECGACAYVCPSNIPLVQYYRQEKAEIRALDQESARAAEAKARFEAKQARLAREKLARELRHKQAAVKLTDADQQTVDAAVSRLTRQSDGSESVINIPAGQMPDNSAVIAAREARKAQARARQAEKQQARSTEETTDVVDPRQAAVAAAIARVKAKKAVQAQHVTTDVAEAGSEAMAEDPRKAAVAAAIARVKAKKAAQAQHVTTDVAEAGSEAMAEDPRKAAVAAAIARVKAKKAAQAINPD
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rnf electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FAT5_CAEEL
Sequence: MTQIKVDAIISKQFLAADLNEIRQMQEESKKQVIKMEIVWKNVALFVALHIGALVGLYQLVFQAKWATVGWVFLLHTLGSMGVTGGAHRLWAHRAYKATLSWRVFLMLINSIAFQNDIIDWARDHRCHHKWTDTDADPHSTNRGMFFAHMGWLLVKKHDQLKIQGGKLDLSDLYEDPVLMFQRKNYLPLVGIFCFALPTFIPVVLWGESAFIAFYTAALFRYCFTLHATWCINSVSHWVGWQPYDHQASSVDNLWTSIAAVGEGGHNYHHTFPQDYRTSEHAEFLNWTRVLIDFGASIGMVYDRKTTPEEVIQRQCKKFGCETEREKMLHKLG
What is the function of this protein?
Delta(9)-fatty acid desaturase that acts preferentially on palmitoyl-CoA (hexadecanoyl-CoA) producing the monounsaturated palmitoleoyl-CoA ((9Z)-hexadecenoyl-CoA), which can be elongated to (11Z)-octadecenoyl-CoA (the most abundant monounsaturated fatty acid in Caenorhabditis elegans phospholipids and triacylglycerols).  Also acts on pentadecanoyl-CoA, heptadecanoyl-CoA and myristoyl-CoA (tetradecanoyl-CoA), the monounsaturated fatty acids (MUFAs) produced are further used as substrates to synthesize polyunsaturated fatty acids (PUFAs) by several other desaturases and elongases (PubMed:16839188, PubMed:10872837, PubMed:29237573).  Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (By similarity).
What are the official names of this protein?
Delta(9)-fatty-acid desaturase fat-5, Fatty acid desaturase 5, FAT-5, Palmitoyl-CoA fatty acid desaturase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SECA_STRMU
Sequence: MANILRTIIENDKGEVRKLTKIAKKVEGYANEMEALSDEELQAKTDEFKERYQNGETLDDLLPEAFAVVREASKRVLGLYPYRVQIMGGVVLHHGDVPEMRTGEGKTLTATMPVYLNALAGEGVHVVTVNEYLATRDATEMGELYSWLGLSVGINLAAKSSSEKREAYNCDITYSTNAEIGFDYLRDNMVVRKENMVQRPLNFALVDEVDSVLIDEARTPLIVSGPVSTETNQLYHRADSFVKTLSEDDYAIDTPTKTIGLKDSGIDKAEEYFHLENLYDIDNVALTHYIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRFSDGLHQAIEAKEGVPIQDESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREIYNMRIIPIPTNRPVARIDHQDLLYPTLEAKFRAVVADVKERHEKGQPVLVGTVAVETSDLISKMLVQAGVPHEVLNAKNHFKEAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDELMRRFGSERIKAFLDRFIEEDNDVVIKSRMLTNQVESAQRRVEGNNYDTRKQVLQYDDVMREQREIIYAERYDVITAERDLAPEIKAIIKRTIERTVDSHSQLDRKESLDAILNFAKTNLLPEDTISLHDIEDLNYEDIKDLLYDAALKNYDRQIAKLRDEEAVREFQKVLILMVVDNKWTDHIDALDQLRSSVGLRGYAQNNPIVEYQSEGFRMFQDMIGAIEFDVTRTMMKAQIHEQEREKETESRTTAEQNISAQSTISPQDPIFKNVGRNDKCPCGSGKKFKNCHGRKRF
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: RL24_STRTD
Sequence: MFVKKGDKVRVIAGKDKGTEAVVLKALPKVNKVVVEGVAIIKKHQKPSAENPQGAIVEKEAPIHASNVQVLDKNGVAGRVGYKVVDGKKVRYNKKSGEVLD
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: MTNK_ERWT9
Sequence: MSQYRTFAAADAVEYARQFGGVDNPNSLVDALEVGDGNLNLVFRIFDTAGVSRVIVKQALPWVRCVGESWPLTLDRARLEAEVLIEHGKFCPQHTVNILHYDPLLAVTVMEDLSDHAIWRADLVKGIDWPQAAGQLGDYLAQTLFHTSDFFQHPHQKKADVIRFTNPELCDITEELFFNEPYEVHARNAYPRALEPLAESLREDHELRVAVAGLKHRFYSNAEALLHGDVHSGSIFVAEGSLKVIDAEFGFYGPIGFDIGSALGNLLISYCAAPGLLPPREAADAREKRLNDVRQLWQSFAEGFLALAAEKSRDRALAVPGYASTFLAKIWRDSVGYSGTELIRRTVGMSQVADIKGIQDDAMRVECVRQAITLGRSLILLADHVADIDALIARIRQNG
What is the function of this protein?
Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
What are the official names of this protein?
Methylthioribose kinase, MTR kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: YETS4_MOUSE
Sequence: MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQTKDI
What is the function of this protein?
Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity).  Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (By similarity).  Also able to recognize and bind crotonylated histone H3 (By similarity).  May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (By similarity).  Plays a key role in histone variant H2AZ1/H2A. Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A. Z (By similarity).  H2AZ1/H2A. Z deposition is required for maintenance of embryonic stem cell (PubMed:29900004).
What are the official names of this protein?
YEATS domain-containing protein 4, Glioma-amplified sequence 41 homolog, Gas41.
What are the subcellular locations of this protein?
Nucleus.
Protein: TNFC_HUMAN
Sequence: MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGAVMVG
What is the function of this protein?
Cytokine that binds to LTBR/TNFRSF3.  May play a specific role in immune response regulation.  Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.  Isoform 2 is probably non-functional.
What are the official names of this protein?
Lymphotoxin-beta, LT-beta, Tumor necrosis factor C, TNF-C, Tumor necrosis factor ligand superfamily member 3.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: Y796_NEIMB
Sequence: MLEIEIVYGLPDRQVLKTMQLAEGTTVRAAALQSGLDGIFEDLNLHSAPLGIFGKAVKDDTPLRDGDRIEVYRPLLIDPKEARRKRVQNQEE
What are the official names of this protein?
UPF0125 protein NMB0796.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: CLH1_HUMAN
Sequence: MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM
What is the function of this protein?
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.  Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.  Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582).  The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825).  Plays a role in early autophagosome formation (PubMed:20639872).
What are the official names of this protein?
Clathrin heavy chain 1, Clathrin heavy chain on chromosome 17, CLH-17.
What is the protein family that this protein belongs to?
Belongs to the clathrin heavy chain family.
Protein: Y2839_SINFN
Sequence: MSDAQGFARDQLRAFIERIERLEEEKKTIADDIKDVYGEAKSMGFDTKILRKVISIRKQDADERLEQEAILDTYLQALGMVPAAEEAA
What are the official names of this protein?
UPF0335 protein NGR_c28390.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: Y3711_VIBCM
Sequence: MIVTTTPNIEGKRIVRYCGVIAGEAILGANIFKDLFAGIRDIVGGRSGTYERELEKARAIALEELQQHAVALGANAVVGIDLDYETFGKANGMLMVSVSGTAVVVE
What are the official names of this protein?
UPF0145 protein VCM66_A0911.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: COX1_PLABE
Sequence: MVLNRYALITNCNHKTLGLYYLWFSFLFGTYGFLLSVILRTELYSSSLRIIAQENVNLYNMIFTIHGIIMIFFNIMPGLFGGFGNYYLPILCGSSELAYPRINSISLLLQPIAFILVILSTAAEFGGGTGWTLYPPLSTSLMSLSPVAVDVIIIGLLVSGIASIMSSLNFVTTVLHLRAKGLSLGVLSVSTWSIIITSIMLLLTLPVLTGGVLMLLSDLHFNTLFFDPTFAGDPILYQHLFWFFGHPEVYILILPAFGVISHVISTNYCRSLFGNQSMILAMGCIAVLGSVVWVHHMYTTGLEVDTRAFFTSTTILISIPTGTKVFNWLCTYMSSNFGITHSSSLLCLLFICTFTFGGTTGVILGNGAIDIALHDTYYVIAHFHFVLSIGAIIALFTCVSFFQESFFGKTLRENTLIVLWSILFFIGVILTFLPMHFLGFNVMPRRIPDYPDALNGWNMICSIGSTMTLFGLLIFK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PARP_SARPE
Sequence: MEIDLPFKVEYSKSSRASCKGCKNKIEAGILRIAAMVQSAFHDGKQPNWFHEQCFFQKQRPTSAGDIENFENIRFEDQERIKKAIDNCTTVISAGGSKKGAKRSKGENNAIKDFGIEYAKSGRASCRGCEQKILKDQIRIRKTVFDTEVGMKYGGQPLWHHVECFAQLRGELGWLDTGENLPGFQTLKSDDKADVKKALPVIKDEGVSSAKKAKIEKIDEEDAASIKELTEKIKKQSKRLFKFRDEIKNEMSKDDMVALLEANNMEPVKGDSEKLLDQVADLLTFGALLPCTDCKGRQLLFHKSGYLCNGDLTEWTKCTKLLKEPERKSCKIPGYLKYKFLKDVRKNPEVRAIRYIPPSTSTILKNISLKKGDELDGPKVKRERPPLYNIEIALIAPKEREGIVKDRISKLGGTVSTKITEKTTVVLSTPEEVERMSSRMKKAKTLGLHVIPEDYLEAVEQNGAGAINYISSMSLCDWGTDPATRITQEESKSSKSKSIYTKSVPKSMTLKIKDGLAVDPDSGLEDVAHVYVSRNKEKYNVVLGITDIQKNKNSFYKLQLLESDMKNRFWVFRSWGRIGTTIGGNKLDNFSNLVDAIVQFKELYLEKSGNHFENRENFVKVAGRMYPIDIDYAEDSKIDLSAEHDIKSKLPLSVQDIIKLMFDVDSMKRTMMEFDLDMEKMPLGKLSQKQIQSAYKVLTEIYELIQGGGTNAKFIDATNRFYTLIPHNFGTQSPPLLDTTEQVEQLRQMLDSLIEIECAYSLLQTEDSKADINPIDKHYEQLKTKLEPLDKNSEEYILLQKYVKNTHAETHKLYDLEVVDIFKVARQGEARRYKPFKKLHNRRLLWHGSRLTNFAGILSHGLKIAPPEAPVTGYMFGKGIYFADMVSKSANYCCTSHHNSTGLMLLSEVALGDMMECTAAKYVTKLPNDKHSCFGRGRTMPNPSESIIREDGVEIPLGKPITNDSLKSSLLYNEFIIYDIAQVNIQYMLRMNFKYK
What is the function of this protein?
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.  Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
What are the official names of this protein?
Poly [ADP-ribose] polymerase, PARP, NAD(+) ADP-ribosyltransferase, ADPRT, Poly[ADP-ribose] synthase, Protein ADP-ribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ARTD/PARP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PFKA_SALSV
Sequence: MIKKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAKRLTEMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFIVVPEVEFNREDLVAEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLEGHGGRCVGIQNEQLVHHDIIDAIENMKRPFKSDWMECAKKLY
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAW_STAA8
Sequence: MKVGIDAGGTLIKIVQEQDNQRTFKTELTKNIDQVVEWLNQQQIEKLCLTGGNAGVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTGTSLHYFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRNTIDLKVRHIYKDTEPPIPGDLTAANFGHVLHHLDADFTPSNKLAAVIGVVGEVVTTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYYVENGAFSGAIGALYLEK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type II pantothenate kinase, PanK-II, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type II pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_HAES1
Sequence: MAIVKCKPTSAGRRHVVKIVNPELHKGKPYAPLLGIKSKTGGRNNLGRITTRHIGGGHKQHYRVIDFKRNKLDIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLSAGDQIQSGINAPIKIGNSLPMRNIPVGSTVHNVELKPGKGGQIARSAGAYVQIIAREGNYVTLRLRSGEMRKVLSECVATIGEVGNSEHMLRVLGKAGANRWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRHNKRTDKYIVRRRGK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RL15_STRSV
Sequence: MKLHELQPAAGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGGGVRLGFEGGQTPLFRRLPKRGFLNINRKEYAIVNLDQLNAFEDGAEVTPVVLIEAGIVKAEKSGIKILGNGELTKKLTVKAAKFSKSAEEAITAKGGSVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RIMO_ACTPJ
Sequence: MSTTPNIGFISLGCPKNLVDSERILTELRTDGYNIIPSYENADLVIVNTCGFIDSAVQESLEAIGEALEENGKVIVTGCLGAKENQIREVHPKVLEITGPHSYEAVMKHVHKYVPRPERNIYTSLVPAQGVKLTPKHYAYLKISEGCDHRCTFCIIPSMRGDLDSRPIVQVLDEAKRLADSGVKELLIVSQDTSAYALDQSKENQNKTVFWNGVPIKNNLITLCEQLGTLGIWVRLHYVYPYPHVDDLIPLMAQGKILPYLDIPLQHASPKVLKAMKRPGAIDRTLERIKKWREICPELTLRSTFIVGFPGETEEDFQMLLDFLEEAQLDRVGCFKFSPVEGAVATEMADQVSEDVKEERFHRFMQVQQRISAARLQQKVGKTLAVIIDEIDEEGIIGRSMADAPEIDGVVYVDNLSEQEVKVGQVISVSITNADEYDLWGTC
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_MYCPU
Sequence: MSNTEQHQKKGQKNKVLLNNDIPFSKVFLIGEDGEKIGIKTKEEALDIARGEKKDLVLISVQPKPIARILDYGKFKYDRKKKEKEQKEKQTNINNRQIRLTPLIGDHDLLTKAKKTRELLLKGDRIKVSLKFKGREIARKELGIDTLNRFYEQVEDIAKIDKEPKLNQDRFLDMYLHPDKQKIAKYLKEKGEDNAKNEK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.