PharMolix/UniProtQA huggingface dataset:
Protein: MANA_SALTY
Sequence: MQKLINSVQNYAWGSKTALTELYGIANPQQQPMAELWMGAHPKSSSRITTANGETVSLRDAIEKNKTAMLGEAVANRFGELPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSDIVSLLQPVAGAHSAIAHFLQVPNAERLSQLFASLLNMQGEEKSRALAVLKAALNSQQGEPWQTIRVISEYYPDDSGLFSPLLLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEPKPAGELLTAPVKSGAELDFPIPVDDFAFSLHDLALQETSIGQHSAAILFCVEGEAVLRKDEQRLVLKPGESAFIGADESPVNASGTGRLARVYNKL
What is the function of this protein?
Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide.
What are the official names of this protein?
Mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI.
What is the protein family that this protein belongs to?
Belongs to the mannose-6-phosphate isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3604L_ASFK5
Sequence: MNSLQVLTKKVLIENKAFSNYHEDDSFILQQLGLWWENGPIGFCKQCKMVTGGSMLCSDVDSYELDRALVKAVKENQTDLIKLFVLWGAEINFGIVCAKTKKMKDLCIQLGADPKFLDEGLYNMFVYLVKQKKVLLAIDIYYDNILILDSFDSHDFHMLIDFMYNRFILNLDEKEEMTRNTLVLKFWYKFAIDFNLIKPIRYLSKKFPHLDDWRLKTAIYLGNVDEIHHAYFQENIRLDPNHMMSFACIHPWNKLGIYYCFALGADIDNALDILLRFDETNKEINRETGRGISLYIEWGYLSNVYFCIGLGANPYIKKIQDTIKQKNSNIMILLFSRKKRILSPHSVLQNKILDPTDVRKMILTHENTENFYPFSELAVRLIQQANI
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-4L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: GCH1_ECODH
Sequence: MPSLSKEAALVHEALVARGLETPLRPPVHEMDNETRKSLIAGHMTEIMQLLNLDLADDSLMETPHRIAKMYVDEIFSGLDYANFPKITLIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILIALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRHEFLRAVRHHN
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: THYX_RICPR
Sequence: MHNTTKRVTVPALEAMLYETIKVLDHGFIRVIDYMGDDSSIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDIKFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPDPANIASQSVVNKQCRAGDSVPKKVSEKVLAILEEDARRCYRHYKELMNADEDGNILDENVSGIARELARINLTLNYYTEWYWKINLHNLLHFLRLRTDPKAQYEIRVYAEKILDIVKAWVPFTYEAFEEYRLQGANISRKGLEVIKRMIKGEKVIHETSGMNKREWEELVKIFR
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: EVL_PONAB
Sequence: MFAFEEFSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGGPSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVSCSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSVSGLAAAIAGAKLRRVQRPEDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQTEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKDEIIDAIRQELSGISTT
What is the function of this protein?
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells.  EVL enhances actin nucleation and polymerization (By similarity).
What are the official names of this protein?
Ena/VASP-like protein, Ena/vasodilator-stimulated phosphoprotein-like.
What is the protein family that this protein belongs to?
Belongs to the Ena/VASP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell projection, lamellipodium. Note=Targeted to the leading edge of lamellipodia and the distal tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F- actin collar and the distal tip of microspikes.
Protein: FENR_ENTFA
Sequence: MSDEKDIYDLTIIGGGPVGLFAAFYAGIRKAKTKIIDSLPQLGGQLTMLYPEKYIYDIPGFPAIKAGELIANLEKQMQPFQHDVCLEEEVTHLAQEADGLLRLDTTKGTHYSKTVIFAIGNGAFQPRRLAIENVEAFEGESIHYYVTDMKKFAGKKVAIAGGGDSAIDWALMLENVAEEVSIIHRRPQFRGHEHSVEQLEKSSVSIRTPYIISDILKENETFTGIQLTETKGDQTLDLPLDDLIINYGFTSSLTHLKEWGLDVSRNAINVHSDMSTNIPGVYAVGDICSYEGKVKLIATGFGEAPTAVNNALHYLRPDARRQPVHSTSLFENGVPK
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: LGT_TOLAT
Sequence: MLFWNADPILIQLGPIAVHWYGALFATGFLLGYQLMQRIYRQEGRPTEQLDKLLTYIFIGTVVGARLAHTLIYEPEYYLAHPIDILKIWEGGLASHGGGIGVLLAIWLFVRQHPENKFLWLADRLAIPTALTGCFIRLGNFMNSEIIGNSTDGSWGVVFERIDTLPRHPVQLYEAASYFAIFVLLLMLFRTTKSKQTGFLFGLFLTLVFAARFIIEYFKTPQAAYEAGNLISVGQWLSVPFVLAGIVLMLLSAKEKAR
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HUTI_VIBCM
Sequence: MNCVLTEARLVTMQPGVQGYQITEPQTLIIEQGRIQHIGQHIDLPSDAHPISCAGKLVTPGLIDCHTHLVYAGSRANEFELRLQGVPYQTIAAQGGGILSTVNATRKASEEALIELALPRLDGLLRSGVTSVEVKSGYGLTLKDELKMLRAAKALEQHRRVKITTTLLAAHALPPEFQGRSDDYIAHICQEIIPRVAEEQLATSVDVFCESIGFSVAQTERVFHAAQAHGLQIKGHTEQLSNLGGSALTARMGGLSVDHIEYLDEAGVKALAQSSTVATLLPGAFYFLRETQKPPIEWLRQYRVPMAISTDLNPGTSPFADLSLMMNMGCTLFDLTPEETLRAVTCHAAQALGYPANRGQIAEGYDADLAIWNIEHPAELSYQVGVSRLHARIVNGELSYES
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METXA_MYCLB
Sequence: MTISKVPTQKLPAEGEVGLVDIGSLTTESGAVIDDVCIAVQRWGELSPTRDNVVMVLHALTGDSHITGPAGPGHPTPGWWDWIAGPGAPIDTNRWCAIATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVEADIAALAAMGITKVAAVVGGSMGGARALEWIIGHPDQVRAGLLLAVGVRATADQIGTQTTQIAAIKTDPNWQGGDYYETGRAPENGLTIARRFAHLTYRSEVELDTRFANNNQGNEDPATGGRYAVQSYLEHQGDKLLARFDAGSYVVLTETLNSHDVGRGRGGIGTALRGCPVPVVVGGITSDRLYPLRLQQELAEMLPGCTGLQVVDSTYGHDGFLVESEAVGKLIRQTLELADVGSKEDACSQ
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_SULDN
Sequence: MGENIAKNKKAYFDYFLEEKFEAGLVLKGSEIKAIRAGRVNLKDSFIRFVQGEAFLFNAHIGRLETTHHFYAHEERGSRKLLLHKKQIQKMIKAVEKDGYTVVPLQLYFNDRNIVKIQIAIAKGKQLHDKRNDLKEKDMKRDMERSMKDY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MSRB_ALKEH
Sequence: MVEVEKSDAEWRAQLTDEQYAVCRQGGTEQPFSGAYYHCKEPGTYHCVCCDAPLFSSRAKYDSGSGWPSFWAPISDDHLRILEDRSLGMVREEVRCARCDAHLGHVFPDGPMPTGLRYCINSVCLDLKRSG
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: DHE4_PYRCJ
Sequence: MSQNGQFLEYTLQVIRRGVEMGGFPEDFYKLLSRPKRIIQVSIPVKMDNGSYEVFEGYRVQHNDALGPFKGGIRFHPEVTLADDIALAMLMTLKNSLAGLPYGGAKGAVRVDPRRLSRRELEELARGYARAVAPLIGEQLDIPAPDVGTDSQVMAWMVDEYSKLAGRNAPAVFTSKPPELWGNPVREYSTGFGVAVAAREVAKRLWGGIEGKTVAVHGAGNTGAWAAYWLEKMGAKVVAISDTRGTVVNKAGIPGEQILKVYMEKKRDKSATVLALEGEKIADSNASLYQDVDILVPAAIENVVREDNVGLVRARLVVEGANGPTTPGAERRLYERGVVVVPDILANAGGVIMSYLEWVENLQWLFWDEEETRRRLEAIMSNNVARVYARWEKEKSWTMRDAAVVTALERIYNAMKTRGWI
What is the function of this protein?
Catalyzes the reversible oxidative deamination of L-glutamate to 2-oxoglutarate and ammonia, thereby playing a key role at the intersection of the carbon and nitrogen metabolic pathways.  Shows a high preference for NADP(+)/NADPH as the acceptor/donor over NAD(+)/NADH.  May function in vivo in the synthetic direction.  Also catalyzes at very low rates the oxidative deamination of L-2-aminobutyrate, and the reductive amination of 2-oxovalerate and 2-oxobutyrate.
What are the official names of this protein?
NADP(+)-dependent glutamate dehydrogenase, NADP-GDH.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: M2_I81A4
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVAAASIIGILHLILWILDRLFFKCIYRRFKYGLKRGPSTEGVPESMREEYRQKQQSAVDVDDGHFVNIVLE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: CTAA_EHRCR
Sequence: MKIASDNREVCVGVKIWLCICCIGILLMVLVGGITRLTHSGLSITEWNPVIGVFPPIGERAWIREKIKYMATPEFKYLNFNITLRGFRKLYLIEYFHRLLGRIVGLTFLIPFLYFTYKKKLHRNLIINFIVICLLILFQGVVGWFMVKSGLIDRPHVSHYKLTAHLLLALLIFYLLWRQFLLSTISKVTYNIKVNGTLIFSVISVLIVTQITFGSLVAGLNAGLLDKTIPFLAGKLMLEDLLFIKPLWYNIFENPVTVQFIHELIATLIFLVVIITLLILRLNLFPAYLLLICLCLQLTLGVLTFIYNVPIVLASLHQVTAFILFAVNTYLLHYMKLSKLQYVK
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CNTB_STAA8
Sequence: MFKFILKRIALMFPLMIVVSFMTFLLTYITNENPAVTILHAQGTPNVTPELIAETNEKYGFNDPLLIQYKNWLLEAMQFNFGTSYITGDPVAERIGPAFMNTLKLTIISSVMVMITSIILGVVSALKRGKFTDRAIRSVAFFLTALPSYWIASILIIYVSVKLNILPTSGLTGPESYILPVIVITIAYAGIYFRNVRRSMVEQLNEDYVLYLRASGVKSITLMLHVLRNALQVAVSIFCMSIPMIMGGLVVIEYIFAWPGLGQLSLKAILEHDFPVIQAYVLIVAVLFIVFNTLADIINALLNPRLREGAR
What is the function of this protein?
Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP).  Involved in the import of divalent metals ions such as nickel, cobalt and zinc.  Probably responsible for the translocation of the substrate across the membrane (PubMed:23279021, PubMed:29581261).  Plays a major role in nickel/cobalt import in zinc-depleted conditions.  Contributes to virulence.  Required for full urease activity in vitro (PubMed:23279021).
What are the official names of this protein?
Metal-staphylopine import system permease protein CntB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EGLX_ASPCL
Sequence: MAPSSLLLSVGSLIASSLASATSLQIREQSQSYQLTESWQGESFINDWNFFDRGDPTNGYVTYVNQSVAESSGLVKVTQSGSFYMGVDYESKLNPDGPGRESVRIESKKYYTQGLYVVDIAHMPGSICGTWPAFWSVGANWPHDGEIDIIEGVNKHDANEIVLHTSGSCDVAGSHDMTGSLTSGECGDASGTIGCVVKGTQGSAGDPFNAQGGGVYAIEWTDSFLKIWFFPRNSIPASITAGKPDSSAFGTPMAHLQGTCDFAERFKEQKFILDTTFCGDWAGNVFGESGCPLSDASSPMRSCVDYVAQNPAAFKEAYWEINSIKIYQLGAAPAPATVASPNTASEVHSASELAPATQTEKPTVPTAAETTVVPPASQTSTVAEETPIAPLATAATVTAVNPAPPATQPTAEPATAVTVTDGGDSFRTIFLTSTTTICPEAQSSSSAAAHGGNKNAPVGAVPGQPSGADAVGNPNPSTTTEAVAETETSQPELTAGGISELPKSAPAPTASQPTSEFKPSDVPDVPKPSPEAEHPAPPAAAGSSIINTPSSSAIFGSSTAVGTFTSLARVSRPTGGATFVPTIATATGSPTVGEDGSSGSATASATLTAPTGILFTAGARKLSVGLSGLVGALAVAALA
What is the function of this protein?
Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.
What are the official names of this protein?
Probable endo-1,3(4)-beta-glucanase ACLA_073210, Mixed-linked glucanase ACLA_073210.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: CRT_PLAYO
Sequence: MTVIKKGKNKKKNLKNDDRYKELDSLITNGSEIGDNSGRSCIKRFFKIIGNEMKNNVYVYFLSILYLCVCVMNKVFAKRTLNKMGNYSFVTSETHNIICIVVFQLLYFIYRKTSTSGYKNESQKNFGWQFFLISLLDASTVIISMIGLTRTTGNIQSFIMQLIIPVNMYFCFMFLGYRYHLFNYLGAFIILITIAVVETFLSFETQSENSIIFNLIMISALIPLSFSNMTREVVFKKHKINILRLNAMVVLFQFFTSLLVLPVYNIPFLKEIYMPFSEMSTNINNGLRCLFYGQNTVVENCGVGMVKMCDNCEGAWKTFITFSFFNICDNLLACYIIDKFSTMTYTIVSCIQGPAITIAYYFKFLAGDAVRKPRILDFLTLFGYLFGTIIYRIGNIILEKKKMVKSQNSNDSEAELTCIETSTA
What is the function of this protein?
May regulate endogenous transporter.
What are the official names of this protein?
Putative chloroquine resistance transporter, Probable transporter cg10, cg10.
What is the protein family that this protein belongs to?
Belongs to the CRT-like transporter family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Localizes to the parasite digestive vacuole, the site of chloroquine action.
Protein: SECA_HELPJ
Sequence: MIKAIIGKIIGTRNDRWIKQYKKKVLAINALEPTYEKMSDVELQNAFEELKKRVRSVEKDLQEKTLLEVLPESFAITREASKRILKMRHFDVQLIGGMVLNDGKIAEMKTGEGKTLVATLAVALNAMKGESVYVVTVNDYLAHRDSKEMEPLYQFLGYSVGTITASVRDDDERLEIYSKDIVYGTNNEFGFDYLRDNMKYSLEHKVQKSHAFAIVDEVDSILIDEARTPLIISGPVDRRMENYNKADEVAKSMQVEVDFTIDEKNRAILITEEGIKKAENLFGVDNLYKIENAALSHHLDQALKANYLFFIDKDYIVANNEVVIVDEFTGRLSEGRRFSEGLHQALEAKEGVSIKEESQTLADITFQNYFRMFSKLSGMTGTAQTEATEFLEIYNLEVVSIPTNLAIKRKDLNDLIYKSEKEKFDAVILKIKELHDKGQPVLVGTASIEKSETLHALLKKERIPHTVLNAKQHTKEAEIIKDAGLKGAVTIATNMAGRGVDIKLTDEVKELGGLYIIGTERHESRRIDNQLRGRSGRQGDPGVSQFYLSLEDNLLRIFGSDRIKGVMEKLGLKDGEHIESKLVTRAVENAQKKVENLHFESRKHLLEYDDVANEQRKSVYKFRDELLDINYDISAKIAENREYALNQIFSKLKAFDHQNLSEEELLGLKNILKEDFNASVELEDLEKASPIEKFVAEKLKSDYENKMKALDSEQRSRIERIVYLQILDNAWREHLYTMDNLKTGINLRGYNQKDPLVEYKKESYNLFLELIGDIKIEAIQTFSKIQFENEQDSSDAERYLDNFSEEREHESVTYRHEEALDEDLNVAVKAFSKTPKRNEPCPCGSGKKYKDCCAKSGPKKGLFAK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: PIPNA_BOVIN
Sequence: MVLLKEYRVILPVSVEEYQVGQLYSVAEASKNETGGGEGVEVLVNEPYEKDGEKGQYTHKIYHLQSKVPTFVRMLAPEGALNIHEKAWNAYPYCRTVITNEYMKEDFLIKIETWHKPDLGTLENVHKLEPEAWKHVEVIYIDIADRSQVLSKDYKAEEDPAKYKSIKTGRGPLGPNWKQELVNQKDCPYMCAYKLVTVKFKWWGLQNKVENFIHKQERRLFTNFHRQLFCWLDKWVDLTMDDIRRMEDETKRQLDEMRQKDPVKGMTADD
What is the function of this protein?
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:7654206).  Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity).  Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity).
What are the official names of this protein?
Phosphatidylinositol transfer protein alpha isoform, PI-TP-alpha, PtdIns transfer protein alpha, PtdInsTP alpha, Phosphatidylinositol-transfer protein 35 kDa isoform, PI-TP 35 kda isoform.
What is the protein family that this protein belongs to?
Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HDAC3_XENTR
Sequence: MAKTVAYFYDPDVGNFHYGTGHPMKPHRLSLTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPNNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYVDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYRHLFQPVIKQVIDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVQYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVDETISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPSDILSYERTDEPDPEERGSEDNYSRPEASNEFYDGDHDNDKESDVEI
What is the function of this protein?
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates.  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression.  Also functions as deacetylase for non-histone targets.  In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively.
What are the official names of this protein?
Histone deacetylase 3, HD3, Protein deacetylase HDAC3, Protein deacylase HDAC3.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MDH_BACC7
Sequence: MTIKRKKVSVIGAGFTGATTAFLLAQKELADVVLVDIPQLENPTKGKALDMLEASPVQGFDANIIGTSDYADTADSDVVVITAGIARKPGMSRDDLVATNSKIMKSITRDIAKHSPNAIIVVLTNPVDAMTYSVFKEAGFPKERVIGQSGVLDTARFRTFIAQELNLSVKDITGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERLEAIVERTRKGGGEIVGLLGNGSAYYAPAASLVEMTEAILKDQRRVLPAIAYLEGEYGYSDLYLGVPVILGGNGIEKIIELELLADEKEALDRSVESVRNVMKVLV
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: Y1756_PYRFU
Sequence: MVNIMDEIIVVTTPTIPGYKIIEVKGIARGGIVMATHLGRDILALLRNIKGGEVKEYTQMMAEAREEALRRMIEHAKKLGANAVVNFRFATSNVGGGMAEVYAYGTAVVVEREK
What are the official names of this protein?
UPF0145 protein PF1756.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: SYI_CAMC5
Sequence: MDYKDTLLLPATDFPMRGDLPKNEPIRLKSWYEERKIYEKMKSKRAGAAKNFAIHDGPPYANGHLHIGHALNKILKDIITKTHYFFGENVRYVPGWDCHGLPIEQQVEVKLGDKKKELSKTQIRELCRAHAREFIDIQREEFKALGIIGDFENPYMTMKFEFEADIYRSLCEIAKKGLLIERSKPVYWSWAAKSALAEAEVEYEDKEDYSIYVAFELDSDALAKLGVKLAKAVIWTTTPWTLPANQAISLKPDEIYVLTSENLIFAKPLLESLVNLGLTKGEILKEFVSNELENTHAINPLNDRKSRFLLGDHVLMDGGTGLVHTAPGHGEDDYYICLRYGFKEILMPVDDGGLYDETLKAHSLLRADVVDSFVGMHIFKANEKIIELLGENLLHVSKFTHSYPFCWRTHKPVIYRATKQWFIAMDEPKLGGKTLREVARGELENVKFYPSVGIKRIGSMIENRPDWCISRQRDWGVPIAFFRRKDTKEPIFEPKILEHIAKIFEQKGADAWWDMSVEELLAPDSGFEAKNLEKVMDILDVWFDSGSTWHAVLNSKNYDAGSYPADMYLEGSDQHRGWFQSSLLVSTAINSHAPYKNILTHGFTVDENGQKMSKSKGNVVAPQDVAKSYGVEILRLWVGLSDYSSDLKISENILKQVSEQYRKIRNTIRFLLANVNDLETIGTDFGFLDQWILGRAKRVFDEASKCFRAYDFSKGFNLLLNFLSADLSGIYLDICKDRLYCDAKDSPRRRSAQSAMAIITKSLLPLIAPTLTYTVDEVMDYAPAIIKGDAKDAFDLVYEPINFDFDVEDELLFASREKFFELIDALKKDKKIKSTLELVLETTSSKILDYDSVERADIYMVSDVHRYSGNEGLGEFEIDGEKFKIVLSDASKCPRCWKFNAIIDGSTCERCSEVLNSVC
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.