PharMolix/UniProtQA huggingface dataset:
Protein: YCIC_ECO7I
Sequence: MSITAQSVYRDTGNFFRNQFMTILLVSLLCAFITVVLGHVFSPSDAQLAQLNDGVPVSGSSGLFDLVQNMSPEQQQILLQASAASTFSGLIGNAILAGGVILIIQLVSAGQRVSALRAIGASAPILPKLFILIFLTTLLVQIGIMLVVVPGIIMAILLALAPVMLVQDKMGVFASMRSSMRLTWANMRLVAPAVLSWLLAKTLLLLFASSFAALTPEIGAVLANTLSNLISAVLLIYLFRLYMLIRQ
What are the official names of this protein?
UPF0259 membrane protein YciC.
What is the protein family that this protein belongs to?
Belongs to the UPF0259 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NHL1_CAEEL
Sequence: MSSSPQNEAEAREKMRELMSRPPSSRPADFVNPLEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCADTLHRNLKCPECRAEHNIPYDGVKAFQPNYTLTGFLEIHLQATPESAAEIEEYIHRYNLERCKICDEKADCEPCAHCDRKACKECRQTHMDMLKRDMSRLLNQVKRLANRITEASDNLSKGVDMMTMNCETTKAEIKEYFHRYQRDLKKKEDNFLMEVDTFQATETRNMSNLRDVLEIESSNMSEAVSRLDAAIKGECSIEDSELVRMKNTFTEGLEYLRNFQPDADELFNRKLRFSAGDDAAKLPAAITTSGELCVLVPQFSGRYLPLEQSYLPRPFRLPLESDSYRVKSDERASMRDREADRTSSRHSHRNPEPDESSIRYRRRQQLEDEAWNRLRNSSAAPSLLTTSVTADSSSRTSPWAADRVTRSVEPTKSRPTSLIVPNTETPRTVSPASKPPLPPQSVERVERTEDASPAPLPQLPIRKPPLPRQQSSNDDSLNEKVETIRRAHQQRQDASRAASRAVSSEESEGEDFPVSTNRGRIRIVCRAASVNRDDGLMSMIPGTGTIINVPPPQHQLPASAPITNGTSEQVAIPVTHFTGEEDESDIVVPAWLQRRRQRFQRSRTNPDIQAQFTSARVQQLLAERQSRLDSSTTTDEEKEKLAVLRQRGRSASREAGEWRARGRPRAVFGRKGAKDGELNWPRGICALSGGLVATCDSSNHRVCVFDKDGKFVRQFGGYGAGAGQLDSAAGLASSKLRVIVSDRYNHRISVFGLEGDHLFSFGGHGQGNAKFNNPWGVAVDDLGSIYVADKDNHRVQVFDKNGQFIAKFGSFGHLPGQLNSPLFIAVSRVTHHVYVSDSSNHRISVFDPHGVHLFSFGEEGFHGGQFKFPRGIAIDSQENLIIADSGNNRIQVFDAQGQFVSSFGTWGGGAGQLKGVEDVCVTADGSIVVTDRENHRIQIF
What are the official names of this protein?
RING finger protein nhl-1.
Protein: GPMA1_BACC1
Sequence: MIKLVLIRHGQSLWNLENRFTGWTDVDLSENGLSEAREAGAILKKNGYTFDVAYTSVLKRAIRTLWIVLHEMDLAWIPVHKCWKLNERHYGALQGLNKDETAKKYGEEQVHIWRRSIDVRPPALTEDDPRYEMNDPRYKALKKGELPLTECLVDTEKRVLAYWHSEIAPSLKSGEKVIISSHGNTIRSLVKYLDNLSSDGVVSLNIPTSIPLVYELDDNLRPIRHYYLSMDGEVPEGEIPKHISF
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1, BPG-dependent PGAM 1, PGAM 1, Phosphoglyceromutase 1, dPGM 1.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: BIOF_BORPE
Sequence: MSKLDSLFTAALEQAAQRQVRRRLRHAAATPPGRLALDGRTLVNFSSNDYLGLARHPLLAERASLWATRHGAGAQASRLVCGNLDLHEQVEAKLARLKGTEAALLLASGWQANAAVLPALFKAAAAQGEPQVYTDRLNHASLHHGCQAAGVRQIRFRHNDLAHLEHLLAERAGAPGARFIVTESVFSMDGDRADVPALAALAARHHAFLYLDEAHATGVLGPRGMGLAGLAPGGVDLAMGTFSKGLGSFGAYVAGSRALCDYLVNACSGFIYTTALPPAVLGAIDAALDLVPRLDQARATLQGHGERLRASLAAQGIDCGASSTQIVPAIIGDAGHALALAAELERRGLLAVAIRPPTVPAGTSRLRIALSAAHGEAELDQLIEALAAGWRAVRQAA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: GBRAP_BOVIN
Sequence: MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL
What is the function of this protein?
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.  Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.  Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.  Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction.  Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation.  Involved in apoptosis.
What are the official names of this protein?
Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Endomembrane system. Cytoplasm, cytoskeleton. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity).
Protein: RL22_RICCK
Sequence: MVQENKNFATAKAKSIRVSPRKLNLVAAFIRNMKVSEALVQLTFSPKRIAKVVKTCLQSAIANAENNLGLDIDRLVVTKATVGKALVMKRVMPRAKGRATRINKFFSNLYITVTEKEDN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CY551_CHLP8
Sequence: MDNKSNGKLIALAIGGAVLMGTLFFLVSFLTGYSPAPNHSAILTPLRSFMGWFLLIFCASLIIMGLGKMSGAISDKWFLSFPLSIFVIVMVMFFSLRFYWEKGRTTTVDGKYIRSVEQLNDFLNKPAATSDLPPVPADFDFAAAEKLTDAKCNKCHTLGSVADLFRTKYKKTGQVKLIVKRMQGFPGANISDDEVIEIGTWLQEKF
What is the function of this protein?
Monoheme cytochrome which is the immediate electron donor to P840 of the photosynthetic reaction center complex.
What are the official names of this protein?
Photosynthetic reaction center cytochrome c-551, Cytochrome c551.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SUFE_PECCP
Sequence: MASLPEPQKLARNFARCNDWEEKYLYIIELGERLDPLPDEWRNPDNLISGCQSQVWIVAQPDEQGVIVLHGDSDAAIVKGLIAVVFSLYQGLTAQEIVELDVRPFFESLALNQHLTPSRSQGLEAMLRAIRAHAAALL
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPT5_YEAST
Sequence: MINNEPFPSADSASILTTSTSNNSLMSYNHQPQLSINSVQSLLEPVTPPPLGQMNNKRNHQKAHSLDLSGFNQFISSTQSPLALMNNTSTSNSANSFSPNPNAASNSTGLSASMANPPAILPLINEFDLEMDGPRRKSSHDFTVVAPSNSGVNTSSLIMETPSSSVTPAASLRNFSNSNNAASKCGVDNSSFGLSSSTSSSMVEISALPLRDLDYIKLATDQFGCRFLQKKLETPSESNMVRDLMYEQIKPFFLDLILDPFGNYLVQKLCDYLTAEQKTLLIQTIYPNVFQISINQYGTRSLQKIIDTVDNEVQIDLIIKGFSQEFTSIEQVVTLINDLNGNHVIQKCIFKFSPSKFGFIIDAIVEQNNIITISTHKHGCCVLQKLLSVCTLQQIFKISVKIVQFLPGLINDQFGNYIIQFLLDIKELDFYLLAELFNRLSNELCQLSCLKFSSNVVEKFIKKLFRIITGFIVNNNGGASQRTAVASDDVINASMNILLTTIDIFTVNLNVLIRDNFGNYALQTLLDVKNYSPLLAYNKNSNAIGQNSSSTLNYGNFCNDFSLKIGNLIVLTKELLPSIKTTSYAKKIKLKVKAYAEATGIPFTDISPQVTAMSHNNLQTINNENKNPHNKNSHNHNHNHNHNHAHNNNNNNNQKSHTRHFSLPANAYHRRSNSSVTNNFSNQYAQDQKIHSPQQIMNFNQNAYPSMGAPSFNSQTNPPLVSHNSLQNFDNRQFANLMAHPNSAAPIHSFSSSNITNVNPNVSRGFKQPGFMMNETDKINANHFSPYSNANSQNFNESFVPRMQYQTEGANWDSSLSMKSQHIGQGPYNQVNMSRNASISNMPAMNTARTSDELQFTLP
What is the function of this protein?
RNA-binding protein involved in post-transcriptional regulation.  Negatively regulates expression of HO by binding to the 3'-UTR of HO mRNA.  Predominantly binds to mRNAs encoding chromatin modifiers and spindle pole body components.  Recognizes and binds to 5'-TGTAA[CT]A[AT]TA-3' in the 3'-UTR of target mRNAs.  Multicopy suppressor of POP2 mutation.  Required for high temperature growth.
What are the official names of this protein?
Suppressor protein MPT5, Protein HTR1, Pumilio homology domain family member 5.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GH109_SHEAM
Sequence: MAGIDRRGFLKASMASVAAAALAGCASQQGTSATPKAAGKSVMGLVVPKMAEVRVGLIGVGERGVGFIHHFNNIEGARITAICDTDPLVISRAQKIMADYGRSQPAYYSKGQQAYLDLVAREDVDIVVIATPWALHHPMAKAAMLAGKHAFVEVPMGMTIEELWDLVDTAELTQRNCMMMENVCYGRDELMVLNMVRQGLFGELLHGEAAYIHELRWQMKELDRKTGSWRTGYHAQINGNLYPTHGLGPVAQYMNINRGDRFDYLSSMSSPALGRAAYAQREFPKDHQRNQLNYICGDMNTSLIKTVKGRTIMVQHDTTTPRPYSRHNLIQGTNGVFAGFPNRIALENHGRGSFHEWDQDMEHWYGKYDHPLWTRMGREAEQNGGHGGMDFLMCWRMIYCLRNGEPLDQDVYDGAAWSAVQPLSAASVADRGNSRDFPDFTRGVWQSATPLGIVE
What is the function of this protein?
Glycosidase.
What are the official names of this protein?
Glycosyl hydrolase family 109 protein.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.
Protein: LACS2_ARATH
Sequence: MSLAADNVLLVEEGRPATAEHPSAGPVYRCKYAKDGLLDLPTDIDSPWQFFSEAVKKYPNEQMLGQRVTTDSKVGPYTWITYKEAHDAAIRIGSAIRSRGVDPGHCCGIYGANCPEWIIAMEACMSQGITYVPLYDSLGVNAVEFIINHAEVSLVFVQEKTVSSILSCQKGCSSNLKTIVSFGEVSSTQKEEAKNQCVSLFSWNEFSLMGNLDEANLPRKRKTDICTIMYTSGTTGEPKGVILNNAAISVQVLSIDKMLEVTDRSCDTSDVFFSYLPLAHCYDQVMEIYFLSRGSSVGYWRGDIRYLMDDVQALKPTVFCGVPRVYDKLYAGIMQKISASGLIRKKLFDFAYNYKLGNMRKGFSQEEASPRLDRLMFDKIKEALGGRAHMLLSGAAPLPRHVEEFLRIIPASNLSQGYGLTESCGGSFTTLAGVFSMVGTVGVPMPTVEARLVSVPEMGYDAFSADVPRGEICLRGNSMFSGYHKRQDLTDQVLIDGWFHTGDIGEWQEDGSMKIIDRKKNIFKLSQGEYVAVENLENTYSRCPLIAQIWVYGNSFESFLVGVVVPDRKAIEDWAKLNYQSPNDFESLCQNLKAQKYFLDELNSTAKQYQLKGFEMLKAIHLEPNPFDIERDLITPTFKLKRPQLLQHYKGIVDQLYSEAKRSMA
What is the function of this protein?
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.  Acts in the cutin pathway.  Preferentially uses palmitate, palmitoleate, oleate and linoleate.  Required for repression of lateral root formation through its role in cutin biosynthesis and subsequent aerial tissues permeability.
What are the official names of this protein?
Long chain acyl-CoA synthetase 2, Protein Botrytis resistant 1, Protein LATERAL ROOT DEVELOPMENT 2.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: PORTL_BPKHP
Sequence: MDFTTLQNDFTNDYQKALIANNEFLEAKKYYNGNQLPQDVLNIILERGQTPIIENMFKVIVNKILGYKIESISEIRLSPKQEEDRALSDLLNSLLQVFIQQENYDKSMIERDKNLLIGGLGVIQLWVSQDKDKNVEIEIKAIKPESFVIDYFSTDKNALDARRFHKMLEVSEQEALLLFGDSVIVNYSNVNHERIASVIESWYKEYNEETQSYEWNRYLWNRNTGIYKSEKKPFKNGACPFIVSKLYTDELNNYYGLFRDIKPMQDFINYAENRMGNMMGSFKAMFEEDAVVDVAEFVETMSLDNAIAKVRPNALKDHKIQFMNNQADLSALSQKAEQKRQLLRLLAGLNDESLGMAVNRQSGVAIAQRKESGLMGLQTFLKATDDMDRLIFRLAVSFICEYFTKEQVFKIVDKKLGDRYFKINSNDDNKIRPLKFDLILKSQLKTESRDEKWYNWNELLKILAPIRPDLVPSLVPLMLNDMDSPITNDVLEAIQNANALQQQNAEANAPYNQQIQALQIQKLQAEIMELQAKAHKYAEQGALSQTTNESEKINQAVAITEMQQQNANNANNEESNNKPKKKLKTSDKTTWRKYPSAQNLDY
What is the function of this protein?
Forms the portal vertex of the capsid.  This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection.  The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel.
What are the official names of this protein?
Portal protein, Head-to-tail connector gp8, Putative portal protein ORF17.
What are the subcellular locations of this protein?
Virion.
Protein: SPA33_BOVIN
Sequence: MRAERLSPLLALGLLVAGIRSVHCLPENVVVKDRHRRVDGHTLASSNTDFAFSLYKQLALKNPNKNVMFSPLSVSMALAFLSLGARGPTLTEILEGLKFNLTEIQETQIHQGFQHLLQALNRPRNQLQLSVGNAMFVQEELKLLDKFIEDARVLYSSEAFPTNFRDPEAAKSLINDYVKNKTQGKIEELFKDLSPRTELVLVNYVYFKAQWKTRFDPKHTEQAEFHVSDNKTVEVPMMTLDLETPYFRDEELGCTLVELTYTSNDSALFILPDKGKMQDLEAKLTPEMLTRWRNSLQPRRIHELYLPKFSIKSNYELNDTLSQMGIKKIFTDADLSGITGTADLVVSQVVHGAALDVDEEGTEGAAATGIGIERTFLRIIVRVNRPFLIAVVLKDTQSIIFLGKVTNPSEA
What is the function of this protein?
Serine protease inhibitor.  Strongly inhibits elastase and trypsin stoichiometrically at the molar ratio of 1:1.  Acts as a moderate inhibitor of plasmin and chymotrypsin.  Does not inhibit thrombin, urokinase, kallikrein, tissue plasminogen activator, cathepsin G or the cysteine proteases papain, cathepsin B or cathepsin L.
What are the official names of this protein?
Serpin A3-3, Endopin-1B, Muscle endopin-1B, mEndopin-1B.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Secreted.
Protein: KITH_SALPA
Sequence: MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNTSLFEEIRAESARQTIHCVLVDESQFLTRQQVYQLSEVVDKLDIPVLCYGLRTDFRGELFVGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQDGRPYNEGEQVVIGGNERYVSVCRKHYKDALEEGSLTAIQERHRHI
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KD3AA_XENLA
Sequence: MVLTQQENLSVLVGQRFTCLLGTDLQLDPDGVSKWPWKSGIVRAASHKDLHCPEIKIFVEFDDEAWEKRTWIELYGATVKMFLVEHNLVLADRVSPSNSVPVQCPAMVYKVLVGKFSLGTATCLQFLGDKDKLFLSKELVKPVRDRETLKQFMQENKTFNKAFQELIRKSVDESRLQQATRNIIGMPINVYSMDPSMQWFSATISNVRTASRALEIKCEQLPSLKIIDPALLHVVLVHNYGDLNDKSRKPRAPKRKSQDTESEDQTELKQTRNEEVPSKDVTQKTSFLTYRRDDGKTLVVVDNPKATNNLFNYINTTTEDQQKVQQQSLSSKQSVPVGFGEALLGCAATTPGILNAATPPQANSPPSFGAATPQGKGTQNLPGDTTLLNGEAKREETNLFLSAAASQGNKRSLGFGMMESPSTFSSLSSMPSWSGQPKSENGPKSENLFAAFTNSSTVFPKGFEFSVKSFPEQKMLSVTDSPKTAPPMTCVQQQEQKVVKKPENNHTSVRAIKPQEPPYPKSPNKNDGVTYPRSILLDPQKLKRLQQSGDCFVQDGSCNDIAPHLHKCRECRLDRFGRSREQRDSAVFCRFFHFRRLHFNKHGMLKEGGFLTPNKYDAEAINLWLPLASNVVDLDLDTAKYILANIGDHFCKLVMSEKEVMSATDPSKQVAWKRAVRGVREMCDACDTTIFNLHWVCPKCGFGVCVDCYRMKKKSLSSGEDGNETFSWLKCVKGQLHEPENLMPTQIVPGKALYDVGDIVHSVRGRWGIKSNCLCSNKHVRPVVKPVVKEEVKPSTPEPEPTKAPLAQPNVCTAPDPIAIPSTPPTPACSSPLSWLTNLSQTTVNKENKDNLFASNLEHKPLPSFASFGKPVSALQTFGSSILTPTTSNNSGFLRNLLNSSTLKQETNEKSTPKILDDIFASLVQSRPLSDFARKPQGLPIQPSLMGFNTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVIVSGIHNNLNSELWRPESFRREFGDQEADLVNCRTNDIITGATVGDFWEGFEDISARLKNDKGEAMVLKLKDWPPGEDFRDTMLSRFEDLMNNIPLPEYTRREGKLNLAARLPAYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDATNVMVYVGIPKGEHDQEQEVIRTIQDGDADELTIKRYIEFKEKPGALWHIFAAKDTEKIRQFLKKVAEEQGHENPPDHDPIHDQSWYLDNTLRKRLLQEHGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSHTHTNHEDKLQVKNVIYHAVKDSIAILKANEASLGKL
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.  Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'.  Demethylation of Lys residue generates formaldehyde and succinate (By similarity).
What are the official names of this protein?
Lysine-specific demethylase 3A-A, JmjC domain-containing histone demethylation protein 2A, Jumonji domain-containing protein 1A-A, [histone H3]-dimethyl-L-lysine(9) demethylase 3A-A.
What is the protein family that this protein belongs to?
Belongs to the JHDM2 histone demethylase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ISPH_HAMD5
Sequence: MKILLANPRGFCAGVYRAISIVESALKIYGPPIYVRHEVVHNRYVVEDLRKRGAIFIEHISQVPDGSVLIFSAHGVSQAVKAQAKARQLKILFDATCPLVTKVHMEVLRASRKGQEAILIGHAGHPEVEGTMGQYDNASAGVYLVESVEDVNQLKVKDENNLCFMTQTTLSVDDTLEITSALQKRFPKIIGPRKDDICYATTNRQQAVRELSEKSDMVLVVGSKNSSNSNRLAELAKRMGKPAYLIDSDADIHADWLKNIKYIGVTAGASAPDVLVQKVIITLQSLGADESIEMMGQEENIVFEIPKQLRIHATEISCS
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: A1K_LOXRE
Sequence: ANKRPAWIMGHMVNAVAQIDEFVNLGANSIETDVSFDKNANPEYTYHGIPCDCGRTCTKWENFNDFLKGLRKATTPGDSKYHEKLVLVVFDLKTGSLYDNQAYDAGKKLAKNILQHYWNNGNNGGRAYIVLSIPNLAHYKLITGFKETLTSEGHPELMEKVGYDFSGNDDIDKVGNAYKNAGVTGHVWQSDGITNCLLRGLSRVKEAVKNRDSSNGFINKVYFWTVDKRASTRDALDAGVDGIMTNYPDVIADVLSESAYKANFRIATYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) with high activity (18. 3 U/mg) (PubMed:16759681).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).  Is lethal to mice (PubMed:16759681).
What are the official names of this protein?
Dermonecrotic toxin LrSicTox-alphaIB1, Lr1, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D 1, SMD 1, SMase D 1, Sphingomyelinase D 1.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily. Class IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMFO_BART1
Sequence: MLKTFDTPIHIIGGGLAGCEASWQIAQSGIPVILHEMRPQKKSDAHKTDKLAELVCSNSFRCDDSSTNAVGLLHAEMRLAKSLIMKAADANKVPAGSALAVDRDGFSKTVTSALENHSLITIKREEVQEISKDWKHVIVATGPLTSPAFAQELKAITGIKALSFFDAIAPIIHTDSIDMNICWYQSRYDKIGPEGTGKDYLNCPLNKEQYETFVEALKNAEKTEFRDFEKTPYFDGCLPIEIMAERGLETLRHGPMKPMGLTNAYNPTVKPYAVVQLRQDNKLGTLYNMVGFQTKLKYGEQVRIFRMIPGLEKAEFARLGGLHRNTYLNSPIILDQTLRLKQKKQLRFAGQITGCEGYVESAAIGLLAGRFAAAEYHHNCPCLPPQTTAFGALLNHITGGHIIDEEAERPSFQPMNINFGLFPPISPIRYSGKRLPSKEKKLAKKQAITARALNDCIQWLADKESKSSCLSKNT
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXK_RHOPB
Sequence: MREPGFWYRPPSLLSSLLRPLGAIYGAVAAHRMAQPGTAVGVPVLCIGNFHGGGAGKTPTALALARLLLELGERPVVLSRGYGGRLHGPVSVDPGRHGAADVGDEPLMMARDIPVVVARDRVAGAALARSRGASVILMDDGFQNPAVAKDAALIVIDGDRGLGNGYVIPAGPLRAPLPPQLARTDALIVVGRGRAADPVAAAVKDNGGLLLRARFLPAEASLAALCDRPVLAFAGIGDPARFFATLRTAGINVAAERVFADHHPYAKQDLAGLTEIAGRDGFTLVTTEKDLARLRSDPAHAAFARSVVPFAVTLEFDDAKALRDFVIEKLTQARDKHRRAGRS
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: TTYH1_HUMAN
Sequence: MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGSKIPSPGGGCVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPRTELVAAARGARRQAEAAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEETGLSSDILSYYLLCNRAVSNPFQQRLTLSQRALANIHSQLLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI
What is the function of this protein?
Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume.
What are the official names of this protein?
Protein tweety homolog 1, hTTY1.
What is the protein family that this protein belongs to?
Belongs to the tweety family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DPH4_DICDI
Sequence: MTNSSNNSNKCENKNYYEILKVSIDADIEEIKKSYRKLALLYHPDKLNKEENIEENINNFSNCLVNNNNNNNNSNTKDFNDIQIAWETLKDDLLRKQYDSLLLEQKRQKYSVSDEIDLDDMEFIEENSEYVYPCRCGDHYIITEDQLSEGSDVVCCSGCSLSIKVIYQME
What is the function of this protein?
Stimulates the ATPase activity of several Hsp70-type chaperones.  Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (By similarity).
What are the official names of this protein?
DPH4 homolog, DnaJ homolog subfamily C member 24.
What is the protein family that this protein belongs to?
Belongs to the DPH4 family.
Protein: PLSY_STRS7
Sequence: MKLILLILTAYLLGSIPTGLWIGQYFYNINLREHGSGNTGTTNTFRILGLKAGAATLLIDIFKGTLATLLPVLVGASNVSPIAIGFFAVLGHTFPIFAGFKGGKAVATSAGVLLGFAPLYLLFLAAVFVLTLYLFSMISLASLTASVVAVISVLTFPAAHFLLPGYDWLLTITIVVLAAIIILRHQDNMKRIKQQSENLIPWGLNLSKQQPTNHH
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LUXS_OCEIH
Sequence: MTKKMNVESFNLDHTKVKAPYVRLVGVTEGANGDKVHKYDIRIKQPNKAHMEMPGLHSLEHLMAENIRNHSDAVLDIGPMGCQTGFYLSLINHDDYDDVLTMIEKTLEDVLQATEVPACNEVQCGWAANHSLLGAQEIAKEMLNEKASWSEVF
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: GCH4_MARSD
Sequence: MEDVQNSPAKVAMSIDRVGVRDLTLPLVVRDRESGSQSTMAKVALSVDLPAHFKGTHMSRFVEALEDWSEELDYQSFYNLLSDILRRLEAERAHAELSFPYCLQKKSPVSGRKGIMSYECTVEGEMVGDNLEFTLGVKVPVMTVCPCSKAISDEGAHSQRAVVHIRTKSKGFVWIEDLVEIAEASGSCEVFSLLKREDEKHVTEKSFSNPTFVEDVVRNAAMGLEKHSKILWYQVDVESFESIHNHCAFASIAKPK
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.