PharMolix/UniProtQA huggingface dataset:
Protein: SCX1_CENLI
Sequence: KEGYLVNKSTGCKYGCFWLGKNENCDKECKAKNQGGSYGYCYSFACWCEGLPESTPTYPLPNKSCS
What is the function of this protein?
Beta toxin that binds site-4 of sodium channels (Nav) and reduces peak current (observed on Nav1. 1/SCN1A, Nav1. 2/SCN2A, Nav1. 3/SCN3A, Nav1. 4/SCN5A, Nav1. 5/SCN4A, and Nav1. 6/SCN8A (IC(50)=44. 9 nM)), shifts the voltage of activation toward more negative potentials (observed on Nav1. 6, Nav1. 1 (weak), Nav1. 2 (weak), and Nav1. 7 (weak)), and induces resurgent currents at negative voltages following brief and strong depolarizations (observed on Nav1. 6, Nav1. 1 (weak), Nav1. 2 (weak), and Nav1. 4 (weak)) (PubMed:22200496).  This toxin is only active on crustaceans (PubMed:7727365).
What are the official names of this protein?
Toxin Cll1, Cll toxin 1, Crustacean toxin 1.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LBD37_ARATH
Sequence: MSCNGCRVLRKGCSENCILRPCIQWIETADAQGHATVFVAKFFGRAGLMSFISAVPDSQRPALFQSLLYEACGRTVNPVNGAIGMLWTGNWNICQAAVETVLRGGSLRPIPELLTHGGGFAGFPSPTSEEASEICTEMLNLQQNDSTDRNIYHHSRFSSSRSRSTMDSSSPTKRKRLSSEDQPSSELDLSLIPNFPIKQATPSSTRRRSVTPSMNSEDSGTTTTTTAFCDKGDVYGNGGGETTKLLNLFV
What are the official names of this protein?
LOB domain-containing protein 37, ASYMMETRIC LEAVES 2-like protein 39, AS2-like protein 39.
What is the protein family that this protein belongs to?
Belongs to the LOB domain-containing protein family.
Protein: NFI_NOCFA
Sequence: MQLSPVTLPTTAEEAMAVQDDLRARVVAANPRPPVFATVAGVDSAYDDAAGLVATAVVVLDTATLEPIESAVAHGPVRFPYVPGLLAFRELPTTLSALEQLRTTPDLLVCDAQGLAHPRRFGLACHVGVRTGLPTIGVAKNAWGAWTEPGRRRGDAAELVLDGEVVGLALRTRDDVKPVFVSVGHHIDLPTAREQVLALTPRYRQPETTRQADRLCRAALRAATGG
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_CHICK
Sequence: MEAMPCHNQRLGAAGGPRPQDEQTAPAGGCSRLIRFAEPSEGSSSGSPSPDSSSGSNGAAAAPSPAAEDCASPLGAQLKLLPMNDQIRELQTIIRDKTASRGDFVFSADRLIRLVVEERLNQLPYTECTVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD
What are the official names of this protein?
Uracil phosphoribosyltransferase homolog.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS6_BURM9
Sequence: MRHYEIVFIVHPDQSEQVPAMIERYKSTITSHGGQIHRVEDWGRRQLAYMIEKLAKAHYVCMNIECDQTTLDELEHAFKFNDAVLRHLIVKMKKAETGPSPMMKEVQREEAKKAAAAQPTEAQA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: MNMG_YERPE
Sequence: MFYPDQFDVIIIGGGHAGTEAAMAAARMGRQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEIDALGGLMAKATDLAGIQFRILNASKGPAVRATRAQADRVLYRLAVRTALENQPNLMIFQQPVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLENYSGGRAGDPPSISLSQRLRELPLRVNRLKTGTPPRIDARTIDFSQLTPQLGDTPIPVFSFLGNAEQHPEQMACHITYTNEKTHEVIRNNLDRSPMYAGIIEGIGPRYCPSIEDKVMRFADRNSHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMKGLENARIIRPGYAIEYDFFDPRDLKPTLESKYIQGLFFAGQINGTTGYEEAAAQGLLAGLNAGRFANEEDGWSPRRDEAYLGVLVDDLSTLGTKEPYRMFTSRAEYRLMLREDNADLRLTETGRKLGLVDDIRWAHFSQKVEQIEKERQRLRDIWVHPHSENVSEINALLKAPLSKEANGEELLRRPEIDYRLLTSLTSFGPALTDPQSADQVEIQVKYEGYITRQQEEIEKQLRNENTLLPVDLDYQQVSGLSNEVIAKLNDHKPSSIGQASRISGITPAAISILLVWLKKQGLLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXG2_CANAL
Sequence: MMLFLIHLMALCCMFVAEVACEQFNSTSNSSSAQSSLIDFQYKGVSIGGWLVLEPYITPSLFNATLSSGETWTDLPVDEYHFCEKLGAKEAEKRLTDHWESMYNETDFKQIKEAGLNMVRIPIGYWSFEKLEGDPYVSGAQDYLDKAIEWSHANDLKVMIDLHGAPNTQNGFDNSGLRNLGYPGWQNKTEYVNHTYKVLQQMFQKYGTGKYASDYKNTIIGIEVLNEPLNPNMDKLKEFYIESYNDGREIQVINNTIFFQEAFQPIGYWDSFLEKGEIKVTETSNGTNHTTTKKADFKNIIIDHHHYEVFTESQVASNVSTHLENIKNYASAIGKEKAKAIVGEWSAALTDCAPWLNGVGLGSRYEGTAPYTNDRVGSCAEFNKSPDKWSKKQKKDYRRFVEMQLYEYSTNSQGWIFWCWKTEGATEWDFRALVKNGIMPQPLDNYKYVKNGTDTSSASAIASNKMTLLLAFLLVILVI
What is the function of this protein?
Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall.  EXG2 is not heavily involved in the exoglucanase function of the adhesion process.
What are the official names of this protein?
Glucan 1,3-beta-glucosidase 2, Exo-1,3-beta-glucanase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Protein: FABZ_AZOSB
Sequence: MDINEIVQYLPHRYPFLLVDRVLELEENKRILALKNVTMNEPFFPGHFPHHPVMPGVLIVEAMAQAAAVLSFKSMGVKPDQNSVVYFAGIDAVRFKRPVVPGDQLLMEVEITQSKRNIYKYKGVARVNGEIATEAELMCALKTLS
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_GLUOX
Sequence: MPLFNPHDLRNLLQSGQRVLGLDPGSKTIGVALTDVSLMLASPLIGLKRRKLGENAQELAKIVRTQDVGALVVGLPLSLDGSFGPAARAASDWTQALSEKLGIPAGLWDERLSSSAVNRFLIKDADMTRGRRAEVVDKMAAAYMLQGWLDASRPEAPEIF
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_STRSY
Sequence: MAKLTVKDVELKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYILEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVAFIAGATRGAELEAAINALEDGQVLLVENTRFEDVDGKKESKNDEELGKYWASLGDGIFVNDAFGTAHRSHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKTLLEKANGKLILPVDSKEANAFAGYTEVRDTDGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_MALP2
Sequence: MSSQVNTTRDSRRKILQGIVVSDKMQKTIVVQVERKSKHRLYKKLVITHKKYHAHDEKEECKIGDFVEIMETRPLSATKRWRLNKIIQKAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: ATR14_STAC4
Sequence: MNVADIAMDLFRGAKGETISIFAIAKVTVTGVSRGLSKLVFGVVDQANLVNLGQYVVYSVVSMIYNITLHPLASFPGPVFWGASRWPSIWRLFKGRLVHDVHALHGQYGHVVRIAPNELAFSSAQAWKDIYGHKRGNNSMEEMPKFHKFYSGISKTPSIVSEPTRDGHRFIRRILSPAFSDKNLRELEPIVQGYISQFIDQLRSHCEDSTGSKVPLDLVSWYNSATFDIVGDLTFGRPFGSLEQGEEDPFIKDINHFAAVGGAMLIFTSHFPGRGILRFLASLGKVFQNGQEKHVTKMEESLVDRMKNKSSRPDIIDGLVKEKDGFQIDYDRVLENAAAITMAGSETTASQLSGLTALLLQNPNCLERLKKEVRSAFKSDKDITSTSSLVGVWQYSANHSPRNFTYPDEFRPDRWLDDRDQKEYEHDHGDAMQPFSVGPRDCPSQK
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the core atranone cluster (CAC) which products are predicted to catalyze most or all steps of mycotoxin atranone synthesis, starting from geranylgeranyl pyrophosphate (GGPP) (PubMed:25015739).  The initial cyclization of GGPP to dolabellane is probably performed by the terpene cyclase ATR13 (PubMed:25015739).  The Baeyer-Villiger oxidation near the end of the atranone synthesis, which converts atranones D and E to atranones F and G is predicted to be catalyzed by the monooxygenase ATR8 (PubMed:25015739).  Of the CAC's other predicted gene products, the reducing PKS ATR6 might synthesize a polyketide chain (PubMed:25015739).  This polyketide is probably transferred onto the atranone backbone by the polyketide transferase ATR5 (By similarity).  Other predicted CAC products include 4 oxygenases (ATR2, ATR3, ATR4, and ATR14), 3 short-chain reductases (ATR7, ATR9, and ATR10), and a methyltransferase (ATR12) (PubMed:25015739).  These may all be involved in the various steps of atranone biosynthesis, although their specific roles must await experimental determination (PubMed:25015739).
What are the official names of this protein?
Cytochrome P450 monooxygenase ATR14, Core atranone cluster (CAC) protein 14.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: POLX_BACSU
Sequence: MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSLSEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIAKLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALRIAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKSVIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGERISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQIKGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKEIDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKRLETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRTEHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFLKRND
What is the function of this protein?
Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA.  The fact that PolX is able to conduct filling of a single-nucleotide gap, allowing further sealing of the resulting nick by a DNA ligase, points to a putative role in base excision repair (BER) during the B. subtilis life cycle.  Moreover, also possesses a 3'-5' exonuclease activity able to edit unpaired 3'-termini in a gapped DNA substrate and likely involved in resecting unannealed 3'-termini during DNA repair.  The same PolX molecule could perform the subsequent gap-filling step.  Does not display 5'-deoxyribose 5'-phosphate (dRP) lyase activity, as predicted by the lack of the lysine and tyrosine residues responsible for the dRP lyase activity in some other PolX members.
What are the official names of this protein?
DNA polymerase/3'-5' exonuclease PolX.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PHP family.
Protein: GB_RHCM6
Sequence: MSKNWFPLLCASVLVVYVSIASSSTGTASGAVTPTSPTENTTGPLIENTTLRTHEVFKINMSKFPYRVCSMAQGTDLLRFEQNINCDSFKPTKEDFEEGIMVVYKRDIRPYTFKVHMYQKILTFRQSYSFIRENHLLGFSQEHLAVPMWEVHYINKLNRCYNSVVRNVAGATYVNYHRDSYVNETMLLVEDDFSNTHSSRFVTVKELWHKPGSTWLYTTSCNVNCMVTVTTARSKYPYDFFVTSDGKVVDISPFYNGSNNKHFGENRDKFSVRKNYSMIAYYGRDNAPEVAHPLVGFFERPDVLMSWDIVEEANNTCEYTFWEQSERTIRSEADDTYHYTSSSMTATFLTSKEELNESDPSFQCIKDKANEQLQLIFNTSYNETYVQSGNVSMYETTGGLIVFWLPVKEKSILEMEELAVAYNNTNSSTRRKRSTDSASDSNKTSEEVLKSIVYAQLQYTYDTLRNYINRALRQIAEAWCKDQKRTLEVFKELSKINPSAMLSAIYDKPIAARFVGDVISLAKCVEVDQNSVKVLRDMRTKESGVCYSRPVVLYTFKNSSHVQYGQLGEYNEILLGRHRTEACEYPSLKIYIAGNSSYEYVDYLYKRMIPLDSISTVDTMISLDIDPLENTDFKALELYSEDELRSSNVFDLEDIMREFNTYKQRMIHVEGKVFDKVPGYLRGLDDMMSGLGSAGKALGVAIGAVGGAVASFVEGVVGFIKNPFGSFTVILFLLAVLGVIYLIYMRQKRAYEKPFEHFFPYVVPPTTVKEAPPSYEQSQYENIKEKAASATKEFSLEEAYQMLLALQKLDQEKRRKAEADDEDFASNGQSAGFLDRLRNRRRGGYQKIQNEYEV
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: THII_YERP3
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTTNIRNVLKHLEDDTLAIVRHWDHIELRTKDDNLGPEICDALTRIPGIHHILEVEDRSYSDMHNIFEQTLEAYRETLVGKTFCVRVKRRGKHEFSSGDVERYVGGGLNQHIESAKVNLTRPQVTVNLEVDQDKLILVKARHEGLGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGSAHEIGVKQVAHYLWNRFGSSHRVRFIAIDFEPVVGEILEKVEDGQMGVVLKRMMVRAASQVAERYGVQALVTGEALGQVSSQTLTNLRLIDNASDTLILRPLISHDKEHIINLARQIGTEDFAKTMPEYCGVISKSPTVKAVKAKIEEEESHFDFSILDRVVSEAKNVDIREIAQQSREQVVEVETVAELADTDVLLDIRAPDEQEEKPLKLDQVEVRSLPFYKLSSQFADLDQSKTYLLYCDRGVMSRLQALYLREQGYTNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFA_ANAD2
Sequence: MTKADIIESVYEKVGFSKKEAAEIVEMVFDTIKETLERGEKIKISGFGNFIVRDKKSRVGRNPQTGEEIEISARRVLTFRPSQVLKNALNGEVSDETTEGADDDDDEEGEGDE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: ATPL_BACP3
Sequence: MSLGVLAAAIAVGLGALGAGIGNGLIVSRTIEGIARQPELRPVLQTTMFIGVALVEALPIIGVVFSFIYLGR
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of 10 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISPT_GEOKA
Sequence: MFNKMRKTKEKDVPVTKEEVLRHPMPNHVAIIMDGNGRWAKKRALPRAAGHYEGMQVVRKITRFANELGIQILSLYAFSTENWKRPKSEVDYLMKLPEQFLTTFLPELVAENVKVQVIGHTEALPDHTRRAVEKAVKETSGNTGLVLNFALNYGSRAEIAAAVKQIAKDVERGMLAPEDITEPLISSYLMTSGLADPDLLIRTSGEIRLSNFMLWQLAYTELWFTDVLWPDFTEQHFLEAIAAYQRRDRRFGGVSAR
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: CYK2_YEAST
Sequence: MSYSYEACFWDPNDNGVNILLGHISQGIRSCDSMILFFKQRSELEKDYARRLGAITGKLDKDIGTNMDYGKLNETFNVVLSVEKARAQSHSKQSEILFRQIYTDTKAFAANLQARYTTLSGKIERLRMDKFNKKKGCEVLQKKLQDAQIRFRDLQLNENNMIGAKRVEHNKRELLKWESNSQEYKVQLDVLKQEYKASQKFWIHEWAQLSCELQEMENARISFLQSKLQQFATSSMETYILEQTKMDMLTNHLNSFTAADEISTFSKENGTGRLKHKTSKGDMNSSANWAQMSSISTTSKKTESYMDNIRKLSSQLKETENKRKLASIDKYEKPLPSPEVTMATQFRNSTPVIRNETKVVANPTLSLRSSPVQLQSNVDDSVLRQKPDKPRPIVGEEQLKPDEDSKNPDEKGLMVHKRNQSLSSPSESSSSNPTDFSHIKKRQSMESMTTSVSSMANSIDDSQRFAKSWNSSNRKRKSMSHLQVPSSASSRSDDGGRTPNSAHNLNEDDYNTRRDTSTSTILFKPPVAVRGTSRGHTHRQSMIMQDSSNPIEDALYEMERIQSSSKPGTKTGNIMDERGVVRDRGITVTLPIVTSEGFPVIEYAKAMYPLIGNEAPGLANFHKGDYLLITEIVNKDWYKGEVYDNDRIDRNHRIGLIPYNFIQLLHQGL
What is the function of this protein?
Throughout most of the cell cycle it forms a double ring that coincides with the septins.  After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring.  Mediates cytoskeletal rearrangements required for cytokinesis.  In conjunction with the medial actin ring exhibits contraction-like action.
What are the official names of this protein?
Cytokinesis protein 2, Homolog of CDC15 protein 1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Bud neck.
Protein: ULAB_SALTI
Sequence: MTVRILAVCGNGQGSSMIMKMKVDQFLTQSNIDHTVNSCAVGEYKSELSGADIIIASTHIAGEITVTGNKYVVGVRNMLSPADFGPKLLEVIKAHFPQDVK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II UlaABC PTS system is involved in ascorbate transport.
What are the official names of this protein?
Ascorbate-specific PTS system EIIB component, Ascorbate-specific phosphotransferase enzyme IIB component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSCL_TRIL1
Sequence: MLQEFKTFIMKGNVLDLAVGVIIGAAFGKIVNSAVNDLIMPVVGLALGKVDFSNLFISLKGGEYATVAAAKAAGAPTLNYGIFLNTTLDFLIMALVIFMIIKAANKVRKTEEPAPAPVPRECPFCKSAVHDEASRCPHCTSQLNATA
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FBSP1_AEDAE
Sequence: MDDDLTEYAPDIPDNVLELIFSYLKLQDLRNCSLVCKSWNRFLNDENNEVWRAQCMQKLSPDAFKTDLLSVVPTYKAKLRAFFHAWNPYDCSRHVYIKPNGFTLHRNPVAQSTDGSRGKIGFQHGRHAWEVRWEGPLGTVAVVGIATKDAAIQCHGYYALLGADDQSWGWNLVDNLLLHNGDAHGIYPLLNNAPKYKVGERIRVILDCDDNTLSFEKNYEFLGVAFTDLPDKVFYPTVAAVYGNTEISMVYLGPPLDG
What is the function of this protein?
Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ).
What are the official names of this protein?
F-box/SPRY domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the FBXO45/Fsn family.
What are the subcellular locations of this protein?
Synapse.
Protein: HNMT_RAT
Sequence: MASFMRSLFSDHSRYVESFRRFLNNSTEHQCMQEFMDKKLPGIIARIGETKAEIKILSIGGGAGEIDLQILSKVQAQYPGICINNEVVEPNAEQIVKYKELVAKTSNMENIKFAWHKETSSEYQKRVVEEDEEPPKWDFIHMIQMLYYVKDIPATLKFFHGLLAANAKILIILVSGTSGWEKLWKKYGFRLPRDDLCQYVTSSDLAQILDDLGIKYECYDLLSTMDITDCFIDGNENGDLLWDFLTETCNFIKTAPLDLKEEIMKDLQEPEFSVKKEGKVLFNNNLSFIVVEANV
What is the function of this protein?
Inactivates histamine by N-methylation.  Plays an important role in degrading histamine and in regulating the airway response to histamine.
What are the official names of this protein?
Histamine N-methyltransferase, HMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDK12_HUMAN
Sequence: MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY
What is the function of this protein?
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation.  Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.  Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'.  Required for RNA splicing, possibly by phosphorylating SRSF1/SF2.  Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
What are the official names of this protein?
Cyclin-dependent kinase 12, Cdc2-related kinase, arginine/serine-rich, CrkRS, Cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, Cell division protein kinase 12, hCDK12.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: BTUD_SALTI
Sequence: MSQLMQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGGAPLEAWATATLAQHRAYLAQQQNPPFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKLGRSVNQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEPMNSLDVAQQNALDRVLHHLCQAGIAIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVEGHPMLISAT
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Vitamin B12 import ATP-binding protein BtuD, Vitamin B12-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.