PharMolix/UniProtQA huggingface dataset:
Protein: IN35_HUMAN
Sequence: MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPMVTTIQMSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNIPDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG
What is the function of this protein?
Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881).  In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963).  In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464).  In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881).  Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465).  Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465).
What are the official names of this protein?
Interferon-induced 35 kDa protein, IFP 35, Ifi-35.
What is the protein family that this protein belongs to?
Belongs to the NMI family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted. Note=Cytoplasmic IFI35 localizes in punctate granular structures (PubMed:10950963). Nuclear localization increased is stimulated by IFN- alpha (PubMed:8288566, PubMed:10950963). Extracelullar following secretion by macrophage (PubMed:29038465).
Protein: RIBX_SHIBS
Sequence: MPVRAQRIQHVMQDTIINFYSTSDDYGDFSNFAAWPIKVDGKTWPTSEHYFQAQKFLDEKYREEIRRVSSPMVAARMGRNRSKPLRKNWESVKEQVMRKALRAKFEQHAELRALLLATAPAKLVEHTENDAYWGDGGNGKGKNRLGYLLMELREQLAIEK
What is the function of this protein?
Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products.  Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do.  Helps maintain flavin levels.  May act on other substrates in vivo.  Has no activity against GTP, nucleoside monophosphates or ADP-ribose.  Is Required for swarming motility.
What are the official names of this protein?
N-glycosidase YbiA, Riboflavin biosynthesis intermediates N-glycosidase.
What is the protein family that this protein belongs to?
Belongs to the YbiA family.
Protein: RDH54_SCHPO
Sequence: MKRRATFQCPLIESTIKHQSTNYTKTETATTSHEVSENANEHKGKSNIDINKIAYYNVVWRKITMKKHKTWEGDGFLVREDSNLTLYNSDFTRLGSCHSRVPQIKEGELLRISGKEISIEKEISAESYEAGTHIDDSLRDVHMPEMKRKFKPPLRPNTMYQTISALPKPRHDPTVLGALVMSRPKTWDPRTHVDVVIDPFLSKHLYSHQREGVSFLYDCLLGMEGKCGYSAILADEMGLGKTLQTITVVWTLLKQSYYANRSSTINNAMVVAPVTLLKNWENEFYNWLGHERIHVYIARCAEDFQEFTSNKTYSIIITGYETVCTYLRNYGCGIDIDLLICDEAHRLKSMSSQTWITLNKLKTRKRLLLTGTPLQNDLSEYFSMVNFIIPGSLGTPNSFKAQYERPILRSRSMNASSRDISLGAARLQRLFEFTSNFTLRRKANILAKHLPPRTDIVLFIKPTHQQENVYGHVLDGFKSSVDQKGYYLKILTRLSKICNSTILLRNEKENFLSTELQDKHVFEQENMLLSSSKLQILAALLKSFQRGCQKAVIVSQYKETLELIELFLSILHVRFCKLLGSTPFSERDLIVHNFNTSSFKEFSVLLLSSKAGGCGLNLTGSTRLIIYEPSWNPAQDLQALSRIYRSGQKRPVCIYTFLSSGMLDERIFIRQNTKQGLSSSFIDSDASQKKNFFTGEDIKTLFSYSKTETCLTYELAFDSDEIDSLTKKKDPLTKIDHTIDSPNTKEKDKEISSWKKASEYMDTNLGKKCPENAFQGWTWQFPNDLSIMNGVEDYIPLEPLPINCLMHKKFE
What is the function of this protein?
Acts with rhp54 to repair meiotic double strand breaks via homologous recombination.  Involved in meiotic DNA recombination.
What are the official names of this protein?
Meiotic recombination protein rdh54, ATP-dependent helicase rdh54, Meiotically up-regulated gene 34 protein, RAD54 protein homolog 2.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DCD_ANAPZ
Sequence: MSVMPDHWIKERALKDGMISPFVDHKEGTGVLSYGLSSYGYDARLDNKFKIFANTHSVVVDPKNFSQDSFVDREGDFCIIPPNSFMLAKTVEYFNIPRDVMVVCVGKSTYARCGIVVNVTPLEPGWSGYVTLEFSNTSPLPVKVYAFEGACQFLFFSGKERCSKSYDEAGGKYMGQSDVTLPIIS
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: RS6_BUCBP
Sequence: MRHYEIILLIHPDCSEKLPIMIEKFKKLVIGYKGRIHRLEDWGRRQLAYSINKLHKAHYFLMNIEVPSNCIQDLSNTFRYDDLVIRNIIMHVKKSVTEISPMLKSKEDKLDKKDRVVVS
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: V011_FOWPN
Sequence: MQKIKLKVSPFFKNLFGPPIEIEEAAGMVSHAANLFASVQLWECAGKAFFKSGDMLLQKNKNSIAAASSFVDAANAFKKIDSYEAINCLSKAIEVYTCLGKFYTVARCHMNIAAIYENDILELDKAIFHYENASGYYGGEGYNKLSDDCMLLIARLSIQKEDFDRAGKIFEQVGYNRMNTMLSKYESRHQLLYAIMCYLCSDVSRAKRSLDKYKDIFPAFKDFKECKFIEKILAACETKNIETFTSAIEEYDHGNTIDEALMSMLLTIRKATFEDEVE
What are the official names of this protein?
Soluble NSF attachment protein homolog FPV011.
What is the protein family that this protein belongs to?
Belongs to the SNAP family.
Protein: CCND2_HUMAN
Sequence: MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL
What is the function of this protein?
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739, PubMed:18827403).  Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739, PubMed:18827403).  Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739, PubMed:18827403).  Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739, PubMed:18827403).
What are the official names of this protein?
G1/S-specific cyclin-D2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin D subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: NHAA_CAMC1
Sequence: MGGIKEFLKHEASGGILLMIATVAALLCQNTFLSDFYNEFLKTKFTVSFGEYGLSKPLILWVNDGLMAVFFFLIGLELKREVLEGELKNPSQIALPAIGAAGGLIVPAVIFYLFTKHDSFALGGWAIPTATDIAFALGILSLLGPRVPTSLKIFLMTLAIVDDLCAIVIIALFYTSELSAQMLAVASVCLAALFALNRLGVKSKAAYLIVGAVMWVAVLKSGVHATLAGVVAAFFIPISFKDEPGKSMLKSIEHDLHGWVAFGVLPIFAFVNAGISLRGVGLDEILSPVALGTALGLFVGKQVGVFSFSFLAIKFKLAKLPEGSNFIQLYGIAVLCGVGFTMSLFINSLAYNDTDAFAYADKLAILLGSVVSGAAGFILLKFSAKNQSARIKECKIQIETIVEKCEIKE
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAT31_SOYBN
Sequence: MEISGSVLRQLSYVSGYGTPTRSRGVASRVGLRMGTGSGFCDEGHLQYYQDTKKILTPKKLKLLKGFSKLGLASDPEKLAMFHDLQQNLTSDAGEVLLRELEAARAKEKEMKKKRKQEIKAKLKASKMNCESSSSSSSESSDSDGDCDQVVDMNCFRAGAGVVVPAPVEESPLPKTPIVEDTNAKAHRDAMALCSKNDISVSSVRDCIKSESAVVTAAPQKRIEVCMGTKCKRSGAAALMQEFERVVGVEGGAVVSCKCMGKCKTAPNVKVQNSVDHSLARGLDDSVNIPANPLCIGVGLGDVDAIVARFLGESHTDIGMIGAATAT
What is the function of this protein?
Involved in triacylglycerol (TAG) biosynthesis (By similarity).  Catalyzes the acylation of the sn-3 hydroxy group of sn-1,2-diacylglycerol using acyl-CoA (By similarity).
What are the official names of this protein?
Diacylglycerol O-acyltransferase 3-1, GmDGAT3-1.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol acyltransferase family.
Protein: MUTL_KLEP3
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGSGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVARLTLTSRTAEQQEAWQAYAEGRDQAVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFGHIDEVVRRIALARFDVTINLNHNGKVIRQYRAVAQDGQRERRLGTICGAAFLEHALAIEWQHGDLTLRGWVADPLHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLDAPLAEKDDPPTPRQMPENRIAAGGNQFARPSEAREAATRFSITSSREPAASGGSSGGASWPHAQPGYQKQQGALYRQLLDTPAAPRPAQPSAAPAELAGHSQSFGRVLTIVGGDCALLEREGSLALLSLTVAERWLRQAQLTPGTEAVCAQPLLIPLRLKVTEGEKRALAAAQSALTQLGIELHTDALHVTVRAVPLPLRQQNLQILIPELIGYLAQQNAFDVGNIAQWMARNLTSEQASWNMAQAIALLADVERLCPQLVKTPPGGLLQPVDLHSAMNALKDE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RIMP_CORJK
Sequence: MVMAFPNKEQLEDSLRGLVNEFGLLIEGIKITKAGAKSAIRIAVDTADPRAERPDLDQLEELSREVSKHLDDAEAAGEMSFGAGYTLELTTPGVDFPLVEQRHWVRNIGRLVRLAGGVERIAQVEGEDVVLITPDKKQPSVRRVRFADVAGAVVEVEFSQAPAAEADLVGLAIDAYGLPGAEDQQDSPAED
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CGEC_BACSU
Sequence: MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLVFAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF
What is the function of this protein?
May be involved in maturation of the outermost layer of the spore.
What are the official names of this protein?
Protein CgeC.
Protein: Y7838_ORYSJ
Sequence: MPLPSCRRREQRPRQSCFQNPECHLRLRARQQRPQESAVQSTLSSSIYFSDHFVLTPPPFQITPTSIQNSTWLPIPTSPAVAAPPLPRCLGGVDGEGAPCAPPPSPIPAGPASSTVSAASSAPATRDYLGGITGHRLGQEDDSGGHEYTSVSGIHVPSSSGVAFVSFGQCPQEVISTDLCLGLGPIAATAPLQPPPPPAAAAAAGSPSATTPEPGHGEATPTTSSSAQFQTQAQQVTRDMWMACAAPKSGRLPTVGSLVYYFPDGHAEQCLSRPQEPLPGRIFLCKVTDVRLGAAATNEALATISLVPIAADDHAFQLQAPADPDPAPAQSQSLVSFVKPLTYTDVTKNRFMVPKDDAAAGVLPHIQLNDDVPLRIKDLSGKEWAFNYTWKAHTRMFRNGWMEFSNANGLVTGDNAVFMRRGNGEMFMAVRRTRNRPAPFSVEEVIEAVWRAARREPFEVSYCLRQDGDEFVVPRDIVDDGLRARFAPGMAVNFVWAVEDGKLPTIGPQGEVISIENYATSIGA
What are the official names of this protein?
B3 domain-containing protein Os07g0183700.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYDP_ECOSM
Sequence: MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: TESA_MYCTO
Sequence: MLARHGPRYGGSVNGHSDDSSGDAKQAAPTLYIFPHAGGTAKDYVAFSREFSADVKRIAVQYPGQHDRSGLPPLESIPTLADEIFAMMKPSARIDDPVAFFGHSMGGMLAFEVALRYQSAGHRVLAFFVSACSAPGHIRYKQLQDLSDREMLDLFTRMTGMNPDFFTDDEFFVGALPTLRAVRAIAGYSCPPETKLSCPIYAFIGDKDWIATQDDMDPWRDRTTEEFSIRVFPGDHFYLNDNLPELVSDIEDKTLQWHDRA
What is the function of this protein?
Involved in the synthesis of both phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs), which are structurally related lipids non-covalently bound to the outer cell wall layer of M. tuberculosis and are important virulence factors.
What are the official names of this protein?
Thioesterase TesA.
What is the protein family that this protein belongs to?
Belongs to the thioesterase family.
Protein: IF4A7_TOBAC
Sequence: MAGLAPEGSQFDARQYDAKMTELLGTEQEEFFTSYDEVYDSFDAMGLQENLLRGIYAYGFEKPSAIQQRGIVPFCKGLDVIQQAQSGTGKTATFCSGVLQQLDYSLVECQALVLAPTRELAQQIEKVMRALGDYLGVKVHACVGGTSVREDQRILQSGVHVVVGTPGRVFDMLRRQSLRPDHIKMFVLDEADEMLSRGFKDQIYDIFQLLPPKIQVGVFSATMPPEALEITRKFMNKPVRILVKRDDVTLEGIKQFYVNVDKEEWKLETLCDLYETLAITQSVIFVNTRRKVDWLTDKMRTRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTQPENYLHRIGRSGRFGRKGVAINFVIKDDERMLSDIQRFYNVVIEELPANVADLL
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
Eukaryotic initiation factor 4A-7, eIF-4A-7, ATP-dependent RNA helicase eIF4A-7.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
Protein: CDSA_HELPJ
Sequence: MKEELFKEKSRYITGVVLIVVAGLILYADNLLLFWAVLGGIYAVGFFEALRLFQVKASFSLYLILVLSWVAAYFNGHPVECALISAMVMASVIAYQKAHHSEAILPFLYPGVGFFALFGVYKDFGAVAIIWLLVVVVASDVGAFFGGKLLGKTPFTATSPNKTLEGALIGVVLASVLGSFVGMGKLSGGFLMALLFSFLIALMAVFGDLYESYLKRKVGVKDSGKILPGHGGVLDRLDSMLFGALSLHVLLYFLEIWKETAVFLGD
What are the official names of this protein?
Phosphatidate cytidylyltransferase, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NCDN_XENLA
Sequence: MPNTTEEQSDEVNNLALEKCLKVLQEAQTDNEQFAALLLVTKCAQAQEINNETRRRIFDAVGFTFPNRLLFSNSVPEGCPQNLFKSLGITLLACFSTDPVLAVHPQVVNKIPIFNETINISCQSGNKEVVSMVEDAYQCLLGILASPQGPKNLLSHGSIPYLCQAYMNRNHFWEKALQILTSLLTVLPPKCWKKSCTDLQLLLTRLSEEFGKEEGEWKFQLADLLPIFLPPSPILLETSWGKQCLKQLCKGLLKILSNKLSISQRDPALKLAACLANSYGSSWIMAENKVVRSRFLALIVNLACVEVRMALEEPEPLTSRQSVITACYALVEMGILACTKEEKHPVLGKEQKLQLIGVMQEACAAIIYYLQQVGWEKQEDPFLLASVRLLGAWLAEETACLKLEVIQLLPFLVHYMRTCHQRSVICSKLPKEVSQVALLSNSWGNIWPGDAIRFLLPALCHLSAEEVPRKVLISEGVPALLCDYFQLQWDVLFAEDEPEGLQSAAELSLQTCCGVFLNLVVTEPTFVGQESCFVSLMKLLMQSLPTLLTKEGHLVLVANFSTLGLMMSRLLAENSVLHESNAEEFFKAAIHFLSHSHVPSCQTDAGKPVITLSESYSEAWEEISELWFLGVQAFSSCVHLLPWLSALVLRSSWLQDTLCLLDNVSPKSVDSDLVTALQGMLTELAQSSSCCRDVIREKGGAEKANLYGMAALEQCLAELS
What is the function of this protein?
Probably involved in signal transduction, in the nervous system.  Required for the spatial learning process.  May also be involved in neurite outgrowth (By similarity).
What are the official names of this protein?
Neurochondrin.
What is the protein family that this protein belongs to?
Belongs to the neurochondrin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell projection, dendrite. Postsynapse.
Protein: DAPE_XANOR
Sequence: MNDVLDLTCDLIARASVTPEDAGCQALLAGRLTAAGFACEHLRLGEVDNLWATHGSGAPVLVLLGHTDVVPPGPREAWTSDPFDPQIRDGVLYGRGVADMKGSVAAFVVAAEQFVAAHRAHAGTLAVLLTSDEEGDAIDGVRRVANLFLERGQAIDWCITGEPSSTERLGDLLRVGRRGSLSGTLTVKGVQGHVAYPHKARNPIHLAAPALAELVARQWDDGFESFPPTSLQVSNIHAGTGANNVIPGELQVAFNLRYTPHWDAPRLEAEITALLDRHALDYALRWHRSGEPFYTPEGRLRSVAREVLGAFAGAPPEESTGGGTSDARFIAPLGAQCIEVGPVNASIHQVDEHVRVADLQALPALYRTLIERLLIE
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: WRP73_HUMAN
Sequence: MNFSEVFKLSSLLCKFSPDGKYLASCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMYKRGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGRYMALAERRDCKDYVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAVWDTCLEYKILLYSLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEFGHPAAINDPKIVVYKEAEKSPQLGLGCLSFPPPRAGAGPLPSSESKYEIASVPVSLQTLKPVTDRANPKIGIGMLAFSPDSYFLATRNDNIPNAVWVWDIQKLRLFAVLEQLSPVRAFQWDPQQPRLAICTGGSRLYLWSPAGCMSVQVPGEGDFAVLSLCWHLSGDSMALLSKDHFCLCFLETEAVVGTACRQLGGHT
What is the function of this protein?
The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome.  Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777).  Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90.  Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole.  Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238).
What are the official names of this protein?
WD repeat-containing protein WRAP73, WD repeat-containing protein 8, WD repeat-containing protein antisense to TP73 gene.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Enriched in the proximal end of the mother centriole (PubMed:26545777). During ciliogenesis also associated with the basal body of the adjacent centriole (PubMed:26675238).
Protein: SYE1_XANP2
Sequence: MSQIVTRFAPSPTGFLHIGGARTALFNWLYARHTGGKMLLRIEDTDRQRSTKEAIAAIIEGLEWLGITCDGDPIYQFARAERHRAAVEEMLAKGNAYRCYATPQELDEMRELARKEGRPPRYDGRWRDRDPSEAPKDRDPVIRLRAPQEGETVIDDMVQGTVTFPNKDLDDLVLLRSDGNPTYMLAVVVDDHDMGVTHVIRGDDHLTNAARQTQIYRALGWEVPRMAHIPLIHGPDGAKLSKRHGALGVDAYRDMGYLPAALRNYLVRLGWSHGDQEVFSTEEMVSFFDLDKVGRSAARFDFQKLESLNGHYMRASSDAELLSAIDALVPHLPDAEHRLARMTPERRAQLAAAMPGLKERAKTLVELVDNAEFIFVERPLPLDDKAAALLSPEARAHLARLVPALEQVEWTAAATEAAVRAYAEAQGVKLGAVAQPLRAALTGKPTSPPIFDVLMVLGRDESLARLKDQAA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHMP5_MOUSE
Sequence: MNRFFGKAKPKAPPPSLTDCIGTVDSRAESIDKKISRLDAELVKYKDQIKKMREGPAKNMVKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKTTVDAMKLGVKEMKKAYKEVKIDQIEDLQDQLEDMMEDANEIQEALGRSYGTPELDEDDLEAELDALGDELLADEDSSYLDEAASAPAIPEGVPTDTKNKDGVLVDEFGLPQIPAS
What is the function of this protein?
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.  ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.  The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis.  ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 5, Chromatin-modifying protein 5, SNF7 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Midbody. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Flemming body.
Protein: KGUA_THET2
Sequence: MRGRLFVMTGASGVGKGTVRAKVLERTRLFYSISMTTRPPRPGEVDGVDYYFVDRPTFEALVREDGFLEYAEYVGHLYGTPRAPVERALSRGEDVLLEIEVQGALQVKRAVPEAVLIFLLPPSLSELKRRLVYRGKDSPEKIQKRLEQAEWEIRNAHLFDYVVVNDVLEEAVADFLAILTAERRRSGRMGEALEMALRRDLALEAELDEILRRRYGGTGH
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI2_RICAE
Sequence: MLKDQNLDIERKQDHIEINLTKNVESTLKSGFESIHFIHNALPEINYDSVNTTTTFLGKSLQAPILISSMTGGTTRARDINYRLAQVAQKAGIAMGLGSMRVLLTEPDTIKTFAVRHIAPDIPLLANIGAVQLNYGVTPKECQYLVDAIKADALILHLNVLQELTQPEGNRNWEKLLPKIREVVNYLSIPVIVKEVGYGLSKKVAESLIDAGVKVLDIAGSGGTSWSQVEAYRATNSLQNRIASSFINWGIPTLDSLKMVREVSKDIPIITSGGLKSGIDGAKAIRIGANIFGLAGQFLKAADTSESLLSEEIQLIIEQLKITMLCTGSRTLKDLAKAEIRL
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_CERSK
Sequence: MNDPLGDMLTRIRNAQLRGKSTVSTPASRLRAWVLDVLQAEGYIRGYEKKETENGQGELVISLKYFEGTPVIRELKRVSKPGRRVYMATKDLPSVRNGLGVSIISTPKGVMSDASARSANVGGEVLCTVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.