PharMolix/UniProtQA huggingface dataset:
Protein: LOLB_SALA4
Sequence: MTLPDFRLIRLLPLASLVLTACTLPGHKGPGKSPDSPQWRQHQQEVRHLNQYQTRGAFAYISDDQKVYARFFWQQTGQDRYRLLLTNPLGSTELELNAQPGNVQLVDNKGQRYTADDAEEMIGKLTGMPIPLNSLRQWILGLPGDATDYKLDDQYRLSEVNYRQDGKNWKVVYGGYDSKTQPAMPANMELSDGSQRIKLKMDNWIVK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: TDA11_VANPO
Sequence: MDSDNVDESVGMLDLKTKFDVFIENGDKNLEMDTGTRATTVPNTPTSDTKNSNSHSSVSPLRSFSRRSGTGSSVGSTAGKTNLSPQLLTPVRLNEGEHPLKDIPSANGSNVKSKSNNKSKRRSLIQPITAPISPDHHGNNFSSAGPVASETRKLSGHQRVISNTSMHSRRSSSQSIMNDVSQDGSLGISSLLQSLASKELELLETKQRIEDLRRQLASEENAYNQGALELKSLKEQVSSYLNPTTFGSNNNNHSIQIADGQDYVIDSTTNELIPTISRAESETKLNIPKSSNSISSGNSKIHSRALSNLSPKQEEGQEDEANESIWSKSLSMFTRLDQIIQQEVEKSLNWESSPEPTASTFAPITEEPGQYYDQNSNSFVRESSRQQNSHNSSEANDNSYSSRSIWNFVSEVKTGLLGKPDDELKGSKPQINTKTDSLEFSNASDDANDSPTIEYNIKQFKTRRKVTGDVEVENSSSKLRDVSIGDNVEEDDNENRIRQVNNRRKVVEMIDFN
What are the official names of this protein?
Topoisomerase I damage affected protein 11.
What is the protein family that this protein belongs to?
Belongs to the TDA11 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NISC_LACLL
Sequence: MRIMMNKKNIKRNVEKIIAQWDERTRKNKENFDFGELTLSTGLPGIILMLAELKNKDNSKIYQKKIDNYIEYIVSKLSTYGLLTGSLYSGAAGIALSILHLREDDEKYKNLLDSLNRYIEYFVREKIEGFNLENITPPDYDVIEGLSGILSYLLLINDEQYDDLKILIINFLSNLTKENNGLISLYIKSENQMSQSESEMYPLGCLNMGLAHGLAGVGCILAYAHIKGYSNEASLSALQKIIFIYEKFELERKKQFLWKDGLVADELKKEKVIREASFIRDAWCYGGPGISLLYLYGGLALDNDYFVDKAEKILESAMQRKLGIDSYMICHGYSGLIEICSLFKRLLNTKKFDSYMEEFNVNSEQILEEYGDESGTGFLEGISGCILVLSKFEYSINFTYWRQALLLFDDFLKGGKRK
What is the function of this protein?
Could be implicated in the processing or the export process of the nisin lantibiotic.
What are the official names of this protein?
Nisin biosynthesis protein NisC.
What is the protein family that this protein belongs to?
To B.subtilis SpaC and S.epidermidis EpiC.
Protein: DTD_ERWT9
Sequence: MIALIQRAQQASVSVAGETTGEIGPGLLILLGVEKGDTPESASKLADKVLGYRIFGDENDKMNLNVQQAGGSVLVVSQFTLAADTKKGMRPGFSAGAAPAEAEKLYDYFAACCREKGATTETGRFAADMKVSLINDGPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_ACIAD
Sequence: MRNVSMTERIIEVVRNTNETKIRVRLNLDGSGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGDLEIDDHHTVEDCGITLGQAFAQALGDKKGLRRYGHFYAPLDESLSRVVVDLSGRPGLFMDIPFTRARIGSFDVDLFSEFFQGFVNHALMTLHIDNLKGKNSHHQIESVFKAFARALRMACEIDPRAAGSIASTKGSL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_RICPU
Sequence: MNNFSIISEYKPAGDQPKAIDEIIAGLSSKKRSQMLLGITGSGKTFTMANIIERTNRPTLIMAHNKTLAAQIYSEMKSLFPKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEQIDLMRHAATRSLLERRDVIVVSSVSCIYGLGSPDLYYQMMVNLEPGQSYLRDQLLNDLINLQYERNDIGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFGNELEYIHEFDPLTGEKLAKLDKAMVFGNSHFVMPQETVNNAISGIEEELQKRLEFLKSQDKPLETQRLNQRTQYDLEMLTETGSCKGVENYSRFFTGRHAGEPPPTLFEYLPEDALLFVDESHVSVPQIRAMYNGDRARKKVLVEHGFRLPSALDNRPLKFEEWDKFRPQTVFVSATPGPFELEETGGTVVELIIRPTGLLDPECIIKPATNQVEDLISEIQTTIAQGFRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVHTLERIEILRDLRQGTIDVLVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGRAARNSAGRVILYADKMTKSIDKAVSETLRRRQIQQEYNEKHGIIPKTINRAIHALAEFEKIDSKLDKKQAHTLFDNPAKLKTHIDKLKKEMLKAASNLEFEQAVKLRDQLKTLEAAALELS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_RUTMC
Sequence: MTKKKSTEKEDINPTIKAVSQTPKEKEDNLKEQLIQAQQSAKDNWDKLLRSQAEMENLKRRNAKDVENAHKFALDSFVKALLEVKDSLSMGIKTAQEEKATVKHIVEGLEMTNKVFLSTLEKFGVVMINPEDEAFNPELHEAVTMIPMPGKDSNSVLEVVQFGFTLNGRLVRPAMVVVAQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAAH_LARHH
Sequence: MDFLTADLCDEFSDRLQILAPGYASFGGHARFAGRIATLKVFEDNSRVREMLSEPGEGRVLVVDGGGSRRCALVGDQLGALAVRNGWAGIVVYGCIRDSVALGLLPLGVRALATHPLKSVKNGVGERELAVTFDGATFRPGDWLYADEDGVITSPDPLL
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: H32_BRANA
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRFRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.2.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: AROE_VIBC3
Sequence: MASQIDQYAVFGNPINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEGAL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: GCH4_SYNC1
Sequence: MRDMQMERDTRNIAIDKVGVKDIRYPIVVMDKNKDQQHTVARINMYVDLPHHFKGTHMSRFVEILNQYRGEITMRNMGELLQEMKNRLDASCAHLKMDFPYFIEKQAPVSKARSLMEYRCRLRGTLDKQKDFVLGVEVPLTALCPCSREISERGAHNQRSAVKVEVRMSKFIWIEDLISWIEECGSAPVYALLKREDEKAVTEQAYDNPMFVEDIVRAVTLKLKSAPEITWFRVECENFESIHNHSAYAMVEFPPRTEDAEPAPAP
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: H2B2D_HUMAN
Sequence: MPEPAKFAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKRVHPDTGIWCKAMGIMNSFLNDIFERIAGEASRLAHYNKRSTITSRRSRRPCACCCPASWPSTPCPRAPRRSPSTPAPSESLPGPGARSLPPSLPPRVAGCFVSKGSFQGHLTPLVK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Putative histone H2B type 2-D, H2B-clustered histone 19 pseudogene.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: QUEF_PROMM
Sequence: MSSTQAQASKTLYGERVIAEGELICFDNPRPERPYEISIELPEFTCQCPFSGYPDFAVLRLLYQPGSRVIELKAIKLYVNSYRNCTISHEEAANKILDDLVVACNPVWMQLEADFNPRGNVHTVVRVSHGSRQPC
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPH4_DEBHA
Sequence: MDPYIEDRDIQKRSHYKVLGVVPTCNDLDIKSAYKEMLLAHHPDKNGNASTTINSIQEAYKTLIDPELRDQYDDSLKRSIQRQGFNITGDGLDIYCLDDFEMEEEEECKWLKDCPRCQFPKSIKFKESDLIENGTEDGDNGFDIIVQCESCSLWIKVKYYEINEEDDE
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue.  Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
What are the official names of this protein?
Diphthamide biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the DPH4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HUA2_ARATH
Sequence: MAPGRKRGASKAKAKGQLVLGDLVLAKVKGFPAWPAKISRPEDWDRAPDPKKYFVQFFGTEEIAFVAPPDIQAFTSEAKSKLLARCQGKTVKYFAQAVEQICTAFEGLQNHKSNALGDEDSLDATEPGLTKAEIVDGTDHIVIESERTDNFNFRVDPCFPKLDENNGEERKAEIRKLDSSSFLESKVKTTSPVSESLEHSSFDPKIKKEDFDKGTDGSACNEHFGNGQKKLANGKRIKKEAGGSDRKGEDTVHRDKSNNSHVPGGRTASGNSDSKKSKGLLTEKTSSKVSADKHENSPGIKVGVSGKKRRLESEQGKLAPRVDESSRAAKKPRCESADNKVKCEIDDGSDSTGTVSDIKREIVLGLGARGGNFQYDKEAVAYTKRQRQTMEHATSPSFSGSRDKSGKGHLEQKDRSSPVRNVKAPAAQSLKKRRAVCIYDEDDDEDPKTPLHGKPAIVPQAASVLTDGPKRANVCHSTSTKAKISAGSTESTEVRKFPLRKHCEDASRVLPSNAENSTNSLPVVKPINELPPKDVKQILQSPKMSPQLVLTNKHVAGQHKVVKSSVKVSGVVMAKKPQSDSCKEAVAGSDKISSSQSQPANQRHKSASVGERLTVVSKAASRLNDSGSRDMSEDLSAAMLDLNREKGSATFTSAKTPDSAASMKDLIAAAQAKRKLAHTQNSIFGNLNPSFLSISDTQGRSHSPFMVQNASASAAISMPLVVQGHHQQGSSPSNHGHQSLSRNQIETDDNEERRLSSGHKSVGGSLSCSTEAAISRDAFEGMLETLSRTRESIGRATRLAIDCAKYGLASEVVELLIRKLESESHFHRKVDLFFLVDSITQHSHSQKGIAGASYVPTVQAALPRLLGAAAPPGTGASDNRRKCLKVLKLWLERKVFPESLLRRYIDDIRASGDDATGGFSLRRPSRSERAVDDPIREMEGMLVDEYGSNATFQLPGFFSSHNFEDDEEDDDLPTSQKEKSTSAGERVSALDDLEIHDTSSDKCHRVLEDVDHELEMEDVSGQRKDVAPSSFCENKTKEQSLDVMEPVAEKSTEFNPLPEDSPPLPQESPPPLPPLPPSPPPPSPPLPPSSLPPPPPAALFPPLPPPPSQPPPPPLSPPPSPPPPPPPPSQSLTTQLSIASHHQIPFQPGFPPPTYPLSHQTYPGSMQQDRSSIFTGDQIVQGPGNSSRGGLVEGAGKPEYFVQQSSSFSPAGVCSSREPSSFTSSRQLEFGNSDVLFNPEASSQNHRFQPSTPLSQRPMVRLPSAPSSHFSYPSHIQSQSQHSYTHPYPFPPQRDDARRYRNEEPWRIPSSGHSAENQNGAWIHGRNSHPGLPRVTDSFFRPPPERPPSGTMNYQPSAASNLQAVPAIPGHTAPQMLPSRPDIPTVNCWRPA
What is the function of this protein?
Transcription factor that functions as repressor of flowering by enhancing the expression of several genes that delay flowering including FLC, FLM/MAF1, MAF2 and SVP (PubMed:15659097).  Also acts in the floral homeotic AGAMOUS (AG) pathway, specifically by processing the AGAMOUS pre-mRNA (PubMed:10198637, PubMed:12530963).  Functions in association with HUA1 and HEN4 in AG pre-mRNA processing (PubMed:12530963).  Involved in all three aspects of the AG functions, the specification of stamen and carpel identities, the control of floral determinacy, and the spatial restriction of AP1 expression (PubMed:10198637, PubMed:12530963, PubMed:15659097).  Acts as transcription regulator that controls anthocyanin accumulation (PubMed:25425527).
What are the official names of this protein?
ENHANCER OF AG-4 protein 2, Protein AERIAL ROSETTE 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: MENG_LACLA
Sequence: MCYNKSMTKVNEERVQEIFNSISSDYDKMNAIISFKQHDLWRAKTMKRMGDLTGLSILDLCCGTGDWTFDLSESVGPSGKVIGLDFSENMLEIAKAKLKEEAKKNIEFLQGNAMALPFEKGSFDVVTIGYGLRNTPDYLTVLKEIFRVLKPGGRVVCIETSHPTLPIYKQAFELYFKNVMPFLGKVFAKSLKEYQWLQKSAEDFPDAKTLEELFRKAGFVAVEYQKHGGGAIASHFATKSQKPKSNIRIGKK
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: RM10_DROPS
Sequence: MANLMQRSLPLTTTRTPVLQFLRFRGKINIQRPKEPHYERARVVAVTQPKYPELPKARSCFQTRAERTKEQLENPYNEIIAREVRNWLNHSQLVAIFHLNSITADEIFRVRVQLHKQNLHLKSYGRKIIDQAVTGTPYEAIMPLFHSNHCIVFSPNQQQIGALLKITRRVPQMVLLGGIVEKTLLSRNELMAYAQMPNLQGAQAQLVQTLNLAAGQLVQHLQTHQANLVQVLDVHAKGNGDTNTNTTETADES
What are the official names of this protein?
39S ribosomal protein L10, mitochondrial, L10mt, MRP-L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL14_YERPB
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGIGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVILNNNSEQPIGTRIFGPVTRELRNEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: PEPT_LACLC
Sequence: MKYEKLLPRFLEYVKVNTRSDENSTTTPSTQALVEFAHKMGEDMKALGLKDVHYLESNGYVIGTIPANTDKKVRKIGLLAHLDTADFNAEGVNPQILENYDGESVIQLGDTEFTLDPKDFPNLKNYKGQTLVHTDGTTLLGSDDKSGVAEIMTLADYLLNINPDFEHGEIRVGFGPDEEIGVGADKFDVADFDVDFAYTVDGGPLGELQYETFSAAGAVIEFQGKNVHPGTAKNMMVNALQLAIDYHNALPEFDRPEKTEGREGFFHLLKLDGTPEEARAQYIIRDHEEGKFNERKALMQEIADKMNAELGQNRVKPLIKDQYYNMAQIIEKDMSIIDIAKKAMENLDIAPIIEPIRGGTDGSKISFMGLPTPNLFAGGENMHGRFEFVSVQTMEKAVDTLLEIIRLNNEVAK
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.  Has a broad specificity for tripeptides with no clear preference for a particular tripeptide.  Tripeptides with proline in the second position are an exception and are not hydrolyzed.  Does not hydrolyze dipeptides, tetrapeptides, or oligopeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_ECOLI
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (PubMed:6251075, PubMed:7629147, PubMed:7629176, PubMed:9753435, PubMed:10551856, PubMed:10660564).  Is essential for growth (PubMed:11952912).
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQA1_HUMAN
Sequence: MKLALLLPWACCCLCGSALATGFLYPFSAAALQQHGYPEPGAGSPGSGYASRRHWCHHTVTRTVSCQVQNGSETVVQRVYQSCRWPGPCANLVSYRTLIRPTYRVSYRTVTVLEWRCCPGFTGSNCDEECMNCTRLSDMSERLTTLEAKVLLLEAAERPSSPDNDLPAPESTPPTWNEDFLPDAIPLAHPVPRQRRPTGPAGPPGQTGPPGPAGPPGSKGDRGQTGEKGPAGPPGLLGPPGPRGLPGEMGRPGPPGPPGPAGNPGPSPNSPQGALYSLQPPTDKDNGDSRLASAIVDTVLAGVPGPRGPPGPPGPPGPRGPPGPPGTPGSQGLAGERGTVGPSGEPGVKGEEGEKAATAEGEGVQQLREALKILAERVLILEHMIGIHDPLASPEGGSGQDAALRANLKMKRGGAQPDGVLAALLGPDPGQKSVDQASSRK
What are the official names of this protein?
Collagen alpha-1(XXVI) chain, Alpha-1 type XXVI collagen, EMI domain-containing protein 2, Emilin and multimerin domain-containing protein 2, Emu2.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: EFM3_YEAST
Sequence: MNEDLFYDRLHQRCPGKYLLEELETSKSNDVLHASRFVCEMELVQKTNAYYCKTIVKMLLDHEWIFAKAFTIVNDGEDEIEIYDYLYEKYIKLLSTGKPDPMMKDVVRYRFDEDVKIKIEETPNLISAASTTGFRTWEAALYMGDFLIHKPLQELAPVQGQDDGKKKLNVLEVGAGTGIVSLVILQKYHEFVNKMYVTDGDSNLVETQLKRNFELNNEVRENEPDIKLQRLWWGSDRVPEDIDLVVGADVTYDPTILPDLCECLAECLALDRCKLCLLSATIRSESTVQLFSQECNKLGLKCTIVTSTEYDANNEIRAMKALQFKPLIAPIRIYKITKQ
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono-, di- and trimethylates elongation factor 2 (EFT1/EFT2) at 'Lys-509'.
What are the official names of this protein?
Protein-lysine N-methyltransferase EFM3, Elongation factor methyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIL1L_HUMAN
Sequence: MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQPLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSKTSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSPEPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRPASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVEPLLLPH
What is the function of this protein?
Acts as a regulator of the antiangiogenic activity on endothelial cells.  When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis.  Inhibits melanoma growth When expressed in tumor-associated vasculature.
What are the official names of this protein?
Filamin A-interacting protein 1-like, 130 kDa GPBP-interacting protein, 90 kDa GPBP-interacting protein, Protein down-regulated in ovarian cancer 1, DOC-1.
What is the protein family that this protein belongs to?
Belongs to the FILIP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Nucleus.
Protein: SYP_VIBCH
Sequence: MRTSNYLLSTLKETPNDAEVVSHKLMLRAGMIRKLASGLYTWLPTGLRVLRKVENIVRQEIDNAGAIETLMPVVQPFELWEETGRSEKMGPELLRFTDRHERPFVLSPTAEEVITALVRNEVSSYKQLPLNLYQIQTKFRDERRPRFGVMRAREFCMMDAYSFDIDKAGLEKSYEAMHVAYCKAFDRMGLDYRPVLADTGAIGGNGSHEFHVLAESGEDLIAFSTESDYAANIEKAEAVAPAIERPAPTQAMTLVDTPNAKTIAELVEQHGLPIEKTVKTLFVKASDEIDAPIVALIIRGDHELNEIKAEKLAEVASPLEMASEEEIRALIGAGPGSLGPVGLKLPFIVDRTVAVMNDFGAGANIDGKHYFGINWGRDVELGKVEDLRNVVEGDPSPCGKGTLMLKRGIEVGHIFQLGTNYSEKMNCGVLDSNGKNVILEMGCYGIGVSRVVAAAIEQNHDDYGIIWPDAIAPFQVAIVPMNMHKSERVQQAAEKLYAELTAAGIEVLFDDRKERPGVMFSDMELIGVPHTIIIGDRSMDEGHFEYKNRRQGEKEAVAMESIIDFIQAKLA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPH_SHEB5
Sequence: MRPSNRTPAQTRPITITRQFTAHAEGSVLVEFGETKVLCTASFTEGVPRFLKGQGQGWVTAEYGMLPRSTHSRMDREAARGKQSGRTQEIQRLIGRALRACVDMKALGENTIVIDCDVIQADGGTRTASITGACVALVDALNWARGKGIIKSNPLKFLIAAVSVGIYKGEAISDLEYIEDSAAETDMNVVMTETGKIIEIQGTAEGEPFSHEELLELLALAKNSIREIVDVQKAALN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.