PharMolix/UniProtQA huggingface dataset:
Protein: MEND_ECO57
Sequence: MSVSAFNRRWAAVILEALTRHGVRHICIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPTHSISLPRPTQDIPARWLVSTIDHALGTLHAGGVHINCPFAEPLYGEMDDTGLSWQQRLGDWWQDDKPWLREAPRLESEKQRDWFFWRQKRGVVVAGRMSAEEGKKVALWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKATSELQQAQIVVQLGSSLTGKRLLQWQASCEPEEYWIVDDIEGRLDPAHHRGRRLIANIADWLELHPAEKRQPWCVEIPRLAEQAMQAVIACRDAFGEAQLAHRISDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASGKPTLAIVGDLSALYDLNALALLRQVSAPLVLIVVNNNGGQIFSLLPTPKSERERFYLMPQNVHFEHAAAMFELKYHRPQNWQELETVLADAWRTPTTTVIEMVVNDTDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: SYL_LIGS1
Sequence: MSYKHIEIEKKWQRYWEEHKTFKTTEDDDKKNYYALDMFPYPSGQGLHVGHPEGYTATDIMARMKRMQGYNVLHPMGWDAFGLPAEQYALNTGNSPREFTKKNVNNFRRQIKSLGLSYDWDREVNTTDPAYYKWTQWIFEQLYKKGLAYEAEVPVNWSPDLGTVVANEEVIDGKTERGGFPVIRKPMRQWVLKITAYADRLIDDLDDLDWPEAIKEQQRNWIGRSVGAAINFPVSGDENTKIEVFSTRPDTIFGVAALVLAPEHELVKQLTTPEHENEVEAYIEKISHKSDLERTDLAKDKTGVFTGSYVVNPVSGEKLPIWIADYVLNSYGTGAVMVVPAHDERDHEFAQKFDLPIVQVIEGGDVQKEAYTGDGVHINSDFLNGMDKEEAIDAINNWLEENGVGEKKVNYRLRDWLFSRQRYWGEPIPVIHWEDGETTLVPEDELPLYLPKATDIKPSGTGESPLANLDDWVNVVDENGRKGRRETNTMPQWAGSSWYFLRYIDPHNNHEIADYEKLKEWLPVNLYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVEQYGADTLRLYEMFMGPLDASIPWSEEGLGGAHKFINRVWNLLIDENDNLRDRVTTINNHDLDKIYNETVKKVTEDYEAMHFNTAISQLMVFVNNAYKADSLPLEYVEGLVKLLSPVVPHITEELWSKLGHVGSIAYAKWPTYDESKLVEDVVEIVVQINGKVRQHLQVSKDASREELQALALNDERIKQELADKEVKKVIAVPGKLVSIVVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_ACIF2
Sequence: MNAERKYLVLLAPVISEKSTMVQQQANQFVFKVARDATKREIRSAVEKLFEVQVLSVQTCNYLGKEKRVGRHVGRRSSWKKAYVRLAEGSSIDYGVA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: GPMI_BACAN
Sequence: MRKPTALIILDGFGLREETYGNAVAQAKKPNFDGYWNKFPHTTLTACGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFDKNETFQSAIKSVKEKGTALHLFGLLSDGGVHSHMNHMFALLRLAAKEGVEKVYIHAFLDGRDVGPKTAQSYIDATNEVIKETGVGQFATISGRYYSMDRDKRWDRVEKCYRAMVNGEGPTYKSAEECVEDSYANGIYDEFVLPSVIVNEDNTPVATINDDDAVIFYNFRPDRAIQIARVFTNGDFREFDRGEKVPHIPEFVCMTHFSETVDGYVAFKPMNLDNTLGEVVAQAGLKQLRIAETEKYPHVTFFFSGGREAEFPGEERILINSPKVATYDLKPEMSIYEVTDALVNEIENDKHDVIILNFANCDMVGHSGMMEPTIKAVEATDECLGKVVEAILAKDGVALITADHGNADEELTSEGEPMTAHTTNPVPFIVTKNDVELREDGILGDIAPTMLTLLGVEQPKEMTGKTIIK
What is the function of this protein?
Essential for rapid growth and for sporulation.  Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: E2PLA_LITPA
Sequence: MFTTKKSMLLLFFLGTISLSLCEEERGADEEEGDGEKLMKRGLFSILKGVGKIALKGLAKNMGKMGLDLVSCKISKEC
What is the function of this protein?
Antimicrobial activity against the Gram-negative bacterium E. coli, the Gram-positive bacterium S. aureus and the yeast C. albicans.
What are the official names of this protein?
Esculentin-2PLa.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Esculentin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ALG8_ARATH
Sequence: MDHREKSDRRLLLWFFAVATAVKLLLIPSSRSTDFEVHRNWLAITNSLPLTKWYFDETSQWTLDYPPFFAYFERFLSIFARLVDPRIVDLQSGLDYNAESVIYFQRISVIVSDLCLLYGVYRLTRKLEPLKRNLICALVIWSPGLLIVDHIHFQYNGFLLGWLLLSISFLQEGRDLLGGFLFAVLLCFKHLFAVTAPVYFVYLLRHYCWSGLVTGFRRLVTIGAVVVAVFAAAYGPFIYHGQIQQVISRMFPFGRGLCHAYWAPNFWVFYIILDKGLAVLLRKLGYEIQIPSASFTGGLVGDSSPFAVLPQITPLTTFAMVLLAISPCLIKAWKKPHSGLVARWVAYAYTCGFLFGWHVHEKASLHFTIPLAIVAVQSLEDAKHYFLVSIVSCYSLYPLLYEPQEYPIKVLLLLLHSVVMWLGFAAQYTDYKAQKKETSEIKSKFRIGCFEKSYLMGLIIVEIVSQFLHPYFLGDKLPFLPLMLISTYCTVGIMYSWIWQLRKILT
What is the function of this protein?
Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
What are the official names of this protein?
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked glycosylation protein 8 homolog, Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG6/ALG8 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MURC_KLEP7
Sequence: MNTQDLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQITTYGFSDDADVRVEDYRQVGAQGHFRLVRQDKAILQVTLNAPGRHNALNAAAAVAVATEEGIDDRAILRALESFQGTGRRFDFLGEFPLAEVNGKPGSAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMVFQPHRYTRTRDLYDDFANVLTQVDALLMLDVYPAGEAPIPGADSRSLCRTIRGRGKVDPILVPDSTQAAEMLASVLTGNDLVLVQGAGNIGKIARHLAEIKLIPQKTEEERHG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPI18_GIBZE
Sequence: MNLLDYKSRPILSLTSIFAAWKSFLLAIALGASIGPDYDTSTSLFFAIVHGASSPRSLATRLTRWDALYFMHDAVKGKVYEQEWAFGIGMPAAVRSICGLLNLQRWEALVAIAISHVSHLVAVLALYQLTIVLCNDRKLAYLASVVHVLSPAGLFISAPYAESPFACMSFVGNLLYAISLKSSPDSLKRNLAVVGAGLSYGISCTLRSNGLFGGVLFAVETVKCLLALRNGFSISKILRLVAPLIGGILVAVGFVAPQVLAWMRYCNGNEEQRAWCGHRIPSIYTFVQAEYWDVGFLKYWTPNQIPLFLLAAPMLTILLKSGTETMREPSRGLGAVAMGTNEESRLLVRTLAAIQTLLAVLAITNYHVQIISRLSSGYPVWYWWVASCLMDKQRQSLGYGVIVFITMYAAIQGGLFASFLPPA
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 2, GPI mannosyltransferase II, GPI-MT-II, Glycosylphosphatidylinositol-anchor biosynthesis protein 18.
What is the protein family that this protein belongs to?
Belongs to the PIGV family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VP18_BPPRD
Sequence: MPFGLIVIGIILAIAAYRDTLGELFSIIKDVSKDAKGFGYWVLAAVILGFAASIKPIKEPVNAFMILLMIVLLIRKRGAIDQISNQLRGS
What is the function of this protein?
Component of the phage injection machinery.  Required for DNA injection in the membrane transformation event.  Involved in the formation of the membrane tail tube to connect the virus interior with the host cytosol.  Essential for viral infectivity.
What are the official names of this protein?
Protein P18, GpM, Protein M.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Note=Part of the capsid inner membrane.
Protein: TC753_ARATH
Sequence: MAAFSVNGQLIPTATSSTASTSLSSRRKFLSPSSSRLPRISTQSPRVPSIKCSKSLPNRDTETSSKDSLLKNLAKPLAVASVSSAASFFLFRISNLPSVLTGGGGGGDGNFGGFGGGGGGGDGNDGGFWGKLFSPSPAVADEEQSPDWDSHGLPANIVVQLNKLSGFKKYKVSDIMFFDRRRQTTIGTEDSFFEMVSIRPGGVYTKAQLQKELETLATCGMFEKVDLEGKTKPDGTLGVTISFAESTWQSADRFRCINVGLMVQSKPIEMDSDMTDKEKLEYYRSLEKDYKRRIDRARPCLLPAPVYGEVMQMLRDQGKVSARLLQRIRDRVQKWYHDEGYACAQVVNFGNLNTKEVVCEVVEGDITQLVIQFQDKLGNVVEGNTQVPVVRRELPKQLRQGYVFNIEAGKKALSNINSLGLFSNIEVNPRPDEKNEGGIIVEIKLKELEQKSAEVSTEWSIVPGRGGAPTLASFQPGGSVTFEHRNLQGLNRSLMGSVTTSNFLNPQDDLSFKLEYVHPYLDGVYNPRNRTFKTSCFNSRKLSPVFTGGPGVEEVPPIWVDRAGVKANITENFTRQSKFTYGLVMEEITTRDESSHIAANGQRLLPSGGISADGPPTTLSGTGVDRMAFLQANITRDNTKFVNGAVVGQRTVFQVDQGLGIGSKFPFFNRHQLTMTKFIQLREVEQGAGKSPPPVLVLHGHYGGCVGDLPSYDAFVLGGPYSVRGYNMGELGAARNIAEVGAEIRIPVKNTHVYAFVEHGNDLGSSKDVKGNPTAVYRRTGQGSSYGAGVKLGLVRAEYAVDHNNGTGALFFRFGERY
What is the function of this protein?
Essential protein.  Mediates the insertion of proteins targeted to the outer membrane of chloroplasts (By similarity).  Required for the import of protein precursors into chloroplasts.  Forms the voltage-dependent preprotein translocation channels (hydrophilic beta barrel) of the TOC complex in the chloroplastic outer membrane.
What are the official names of this protein?
Protein TOC75-3, chloroplastic, 75 kDa translocon at the outer-envelope-membrane of chloroplasts 3, AtTOC75-III.
What is the protein family that this protein belongs to?
Belongs to the TOC75 family.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane; Multi-pass membrane protein.
Protein: RMLC_MYCS2
Sequence: MTARELSIAGAWEITPVLRTDSRGLFFEWFTDAGFTEFAGHQFDMRQANCSVSARGVLRGVHFAQVPPSQAKYVTCVRGAVFDVVVDIRVGSPTFGQWDAVLLDDKDRRSIYISEGLGHAFLALDDDSTVMYLCSAPYAPQREHTVRPTDFGIEWPEVPELILSDRDAQAPSLAEAQAAGVLPTWADCQAFVETLRRNLVS
What is the function of this protein?
Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.  Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage.
What are the official names of this protein?
dTDP-4-dehydrorhamnose 3,5-epimerase, Thymidine diphospho-4-keto-rhamnose 3,5-epimerase, dTDP-4-keto-6-deoxyglucose 3,5-epimerase, dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase, dTDP-L-rhamnose synthase.
What is the protein family that this protein belongs to?
Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
Protein: SECA_CHLTE
Sequence: MLKIIAKIFGSKHEKDIKKIQPIVDRINEIYGTLNALPDEAFRNKGVELRKKVRDKLIPFETKIKETEHKLERPDMSHEEHEKLNIELEQLRNKYEEATAAILDEVLPETFALVKETCRRLKGHTYTVMGHEMVWDMVPYDVQLIGGIVLHQGKIAEMATGEGKTLVSTLPVFLNALTGRGVHVVTVNEYLAQRDMEWMRPVYEYHGLSTGVILAGLYSNQRRNAYLCDITWGTNSEFGFDYLRDNMAGSEEEMVQRDFYFAIVDEVDSVLIDEARTPLIISGPVPNSDTDTKYREIKPWIEQLVRAQQNLVATLLDQAEKTLKEKPNDFDAGLALLRVKRGQPKNKRFIKMLSQPGIGKLVQSVENEYLKDNSSRMHEVDDELFYAVDEKANTIDLTEKGREFLGKLSHQDQDLFLLPDVGSEIAAIEADKNLQPTDKIRKKDEVYRLYSERSDSLHTIGQLLKAYTLFAKDDEYVVQNGQVMIVDEFTGRVLAGRRYSDGLHQAIEAKENVKIEGETQTMATITIQNYFRLYSKLAGMTGTAETEASEFFEIYKLDVVVIPTNHPIARHDQDDLVYKTRREKYNAIVNKVQELNAKGQPVLVGTASVEVSETLSRMLRAKRIQHNVLNAKQHAREAEIVAMAGQKGAVTIATNMAGRGTDIKLGPGVREMGGLFILGSERHESRRIDRQLRGRAGRQGDPGESIFYVSLEDDLMRLFGSDRVIAVMDKLGHEEGDVIEHSMITKSIERAQKKVEEQNFAIRKRLLEYDDVMNQQREVIYTRRRKALKMGRLKNDIMDLLQDYCYTVAKKFHESNDPAGLEEQVLRELSVEFHVEASAFEREPFEQTAEALYKAASEFYHRKENSLPDEIMQQIEKYAVLSVIDQKWREHLREIDSLREGINLRAYGQKDPLLEYKQEAYKLFVELLREIEHETLSVAFRLFPVSQDESEEIEARQRRQAVRQERLVAQHAEAESTYKIAADGGMNATLWMPGDEIVVQQPVRTEKKPGRNDDCPCGSGKKYKNCCGANE
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: KV230_HUMAN
Sequence: MRLPAQLLGLLMLWVPGSSGDVVMTQSPLSLPVTLGQPASISCRSSQSLVYSDGNTYLNWFQQRPGQSPRRLIYKVSNRDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 2-30, Ig kappa chain V-II region RPMI 6410.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: Y2644_ACIAD
Sequence: MLPFKLWVDADALPRILREVILRASDRYQLEVTFVANQNVGITPSVRIKSIQVMSGADRADQEIVDRMQANDIVITQDIPLAAQVIEKGGIAIHPRGEVYTTANVKARLHLRDFMDTLRGAGVQTGGPPPISERDKREFSSALDQTILKQKRKTA
What are the official names of this protein?
UPF0178 protein ACIAD2644.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: NRDR_AROAE
Sequence: MKCPFCGDPNTQVADTRENEGGEVVRRRRRCPKCDKRFTTYERIDLKMPHIVKRNGNRSEFEHDKLAGSMKLALRKRPVTLEALDAAVDRIEAKLLALGEQEVPSEKVGELVMRELKKLDKVAYIRFASVYRNFADVDEFAEVIREVKARPKRNRPAEPPEPTSENDLFRS
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: THIM1_CLOBM
Sequence: MQIRQSVKFKKPLIHYITNPISINDCANMILAVGAKPIMAEHPLEVSEITSISESLGINLGNITDNKMKSMLISGKTSYEKKIPQVIDLVGVGCSKLRLDYAKKFISECHPNVIKGNMSEIKAIYGIKSSAKGIDVGECDIITEQNFDENIEMIKRLSMETDSVVAATGVVDIISNGTYTYIISNGCEMLSMITGTGSMLTGIIASYISSGNILEGTALAIAIMGICGELSQNVKGTGSFRNELIDNMFSISDDIIIKKIRINSY
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 1, 4-methyl-5-beta-hydroxyethylthiazole kinase 1, TH kinase 1, Thz kinase 1.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: GLMU_THESQ
Sequence: MRALVLAAGKGTRMKSKIPKVLHPLSGKPMIEWVVETAGKVAQKVGVVLGFEAELVRKTLPEWVDVFVQEEQLGTAHAVMCAKDFIEPGDDVLILYGDVPLISENTLKRMIEEHRKGADVTILVADLEDPSGYGRVIQDGDKYRIIEDADLPEELKSVTTINTGFYVFSGDFLLRALPEIKNENAKGEYYLTDAVNFAEKVRVVKTDDLLEITGVNTRKTLVWLEEQLRMRKIEELLENGVTILDPATTYIHYSVEIGMDTVIHPMTFIEGKSRVGENCEIGPMTRIVDCEIGNNVKITRSECFKSVIEDDVSVGPFARLREGTILKKSSKIGNFVEIKKSTIGEGTKAQHLSYIGDAFVGKNVNIGAGTITCNYDGKKKNPTFIEDGAFIGSNSSLVAPVRIGEGALIGAGSVITEDVPPYSLGLGRAMQVVKEGWVLKKRKEE
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_MARMM
Sequence: MNHALNIDARNGNAPRIDETTPRALPSLAGMTREELRLVAIDCGVEEKKAKMRAEQLWRWIYHYGVTSFDEMTNISKDLRAVIADKYALHRPKLIDRQVSVDGTRKYLIELAPGVECETVFIPDVARSGALCVSSQVGCTLNCTFCHTGTQALVRNLTAAEIVAQVMIARDDLDEWPTSNENRKITNIVFMGMGEPLYNLDHVATSIDIISDGEGIAISRRRTTVSTSGVVPKIEELGARTGTMLAISLHATNDTLRDELVPLNKKYPLVELMNAIRAYPGLGNSKRVTFEYVMLKGVNDSLAEAKALVKLLKGIPAKINLIPFNPWPKSPYECSDWDQIEAFADVVNKAGYASPIRTPRGRDIFAACGQLRSESQKVKASVLRKQRLADGASPQA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_CHESB
Sequence: MRSGVIAQKIGMTRVYNETGEHIPVTVLRMENCQVVAQRTEEKNGYTAVQLGVGLAKVKNTSKALRGHFAAASVEPKAKVAEFRVSPENLLDVGAEITADHFVPGQKVDVTGTSIGKGFQGVMKRHNFGGGRATHGNSVSHRTHGSTGQRQDPGKVFKGKKMAGHMGDRRVTTQNLEVVSTDTERGLILVRGAVPGSKGSWIMVRDAVKAPLPKEAPLPAAIRASNNNAEKAAATAAGEGAE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RL20_LIMRJ
Sequence: MRVKGGTVTRARRKRIMKLAKGYRGSKHRLFKTAKDQVMKSYAYAFRDRKVNKRKFRELWIARINAAARMNDISYSKLMHGLKVANIDINRKMLADLAVNDADAFKALVDEAKKALN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: WRK17_ARATH
Sequence: MTVDIMRLPKMEDQTAIQEAASQGLKSMEHLIRVLSNRPEERNVDCSEITDFTVSKFKKVISLLNRSGHARFRRGPVHSPPSSSVPPPVKVTTPAPTQISAPAPVSFVQANQQSVTLDFTRPSVFGAKTKSSEVVEFAKESFSVSSNSSFMSSAITGDGSVSKGSSIFLAPAPAVPVTSSGKPPLSGLPYRKRCFEHDHSEGFSGKISGSGNGKCHCKKSRKNRMKRTVRVPAVSAKIADIPPDEYSWRKYGQKPIKGSPHPRGYYKCSTFRGCPARKHVERALDDSTMLIVTYEGEHRHHQSTMQEHVTPSVSGLVFGSA
What is the function of this protein?
Transcription factor.  Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
What are the official names of this protein?
Probable WRKY transcription factor 17, WRKY DNA-binding protein 17.
What are the subcellular locations of this protein?
Nucleus.
Protein: G6PI_XANCP
Sequence: MTHTNGFDALHAHAQRLRGAAIPALLAAEPQRPTQYARQVGPLYFNFARQKYDRAALDALFAIARERDLAGAFQRLFRGEQVNVTEQRAALHTALRGDLTDAPVASDAYATAAEVRQRVGALIQQLEGTDVTDIVSVGIGGSDLGPRLVADALRAPSGARFRVHFVSNVDGAAMQRTLATLDPARTAGILISKTFGTQETLLNGSILHAWLGGSERLYAVSANPERAAKAFDIAPGRVLPMWDWVGGRYSLWSAVGFPIALAIGFERFEQLLDGAAQFDAHVLNTPLEENVAVLHGLTAVWNRNLLGSATHAVMTYDQRLALLPAYLQQLVMESLGKRVKLDGAAVDSDTVAVWWGGAGTDVQHSFFQALHQGTSVVPADFIGTVHNDDPYAENHVALMANVLAQTEALANGQDSSDPHRSYPGGRPSTVILLDALTPQALGALISMYEHSVYVQSVMWGINAFDQFGVELGKQLASQLLPALKGEAADVADPVTRELLAKLRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RE113_HUMAN
Sequence: MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSYGVPNSSEETATIENGP
What is the function of this protein?
Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript.  Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery.  This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).
What are the official names of this protein?
Endogenous retrovirus group K member 113 Rec protein, HERV-K113 Rec protein, HERV-K_19p13.11 provirus Rec protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity).
Protein: CB5D1_PONAB
Sequence: MSRRGLVAGPDLEYFQRRYFTPAEVAQHNRPEDLWVSYLGRVYDLTSLAQAYKGNLLLKPIVEVAGQDISHWFDPKTRDIRKHIDPLTGCLRYCTPRGRFVHVPPQLPCSDWANDFGKPWWQGSYYEVGRLSAKTRSIRIINTLTSQEHTLEVGVLESIWEILHRYLPYNTHAASYTWKYEGKNLNMDFTLEENGIRDEEEEFDYLSMDGTLHTPAILLYFNDDLTEL
What is the function of this protein?
Radial spoke stalk protein that binds heme under oxidizing conditions.  Required for the coordinated beating of multiple cilia maybe by functioning in a redox signaling pathway.
What are the official names of this protein?
Cytochrome b5 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b5 family.
Protein: SYL_MYCLB
Sequence: MTELPTTVPGYNSAVAQTDSDAMRYRYTAELAGRIESTWQDNWARLQTFNVPNPVGSLAPPDGSVVPADKLFVQDMFPYPSGDGLHVGHPLGYIATDVYARYFRMTGHNVLHAMGFDAFGLPAEQYAMQTGTHPRILTEANVVNFRHQLGRLGLGHDSRRTFSTTDVEFYKWTQWIFLQIYNAWFDVAANKARPIAELIAEFDSGERRLVDGRDWATLSAGERADVIDNCRLVYRADSMVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYADRLLDDLDLLDWPEQVKTMQRNWIGRSSGATVLFSAILSRSDAATTEVDVEVFTTRPDTMFGVTYLVLAPEHNLVDELVATVWPDRTDPRWTYGAATPGAAVAAYRRAIVAKSDLDRQESKEKTGVFLGRYATNPATGKPVPIFVADYVLVGYGTGAVMAVPGHDPRDWDFAHKFHLPIVEVIAGSDISEAAYVGDGVLVNSGYLDGMDVATAQEAITARLESEGRGHARIEFKLRDWLFARQRYWGEPFPIIYDSDGRPHALDEAALPVELPDVPYYSPVLFDPDDADSEPSPPLAKATEWVHVELDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNSERLCAKENEAYWMGPRPTEHGIDDPGGVDLYVGGAEHAVLHLLYARFWHKVLYDLGHVSSREPYRRLINQGYIQAFAYTDAHGSYVPANQVFQRGDGFFCPGPDGEIEVFQEFGKIGKSLKNSVSPDEICDEYGADTLRVYEMSMGPLEASRPWATKDVVGAYRFLQRVWRLVVDERTGETRVVDTAGELDTYTLRTLHRTIAGVSQDYAALRNNTATAKLIEYTNHLTKEHRGSVPRVAVEPLVLMLAPLAPHLAEELWLRLGHTTSLANGPFPQADPAYLVDDTVEYPVQVNGKIRGRIVVAADADYDTLKTVALADDKVQQFLAGATPRKVIVVAGRLISLVI
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.