PharMolix/UniProtQA huggingface dataset:
Protein: RSXE_ECO5E
Sequence: MSEIKDVIVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTISTLRHWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPALSALDGFSIGMGATCAMFVLGSLREIIGNGTLFDGADALLGSWAKVLRVEIFHTDSPFLLAMLPPGAFIGLGLMLAGKYLIDERMKKRRTEAAAERALPNGETGNV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rsx electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GPMA_SALTI
Sequence: MAVTKLVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGFSFDFAYTSVLKRAIHTLWNVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPELTKDDERYPGHDPRYAKLSEKELPLTESLALTIDRVIPYWNDTILPRMKSGERVIIAAHGNSLRALVKYLDNMSEDEILELNIPTGVPLVYEFDENFKPIKHYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: LFTR_AERHH
Sequence: MSRYLTQLDDELCWFPDPEHALEEPNGLLAIGGDLSPARLLAAYHKGIFPWNEPHQPLLWWSPDPRGVIRPEQLHIGRTLRKFIRGTSFDISIDRAFNEVIAACAAPRRSASGTWISTPMIDAYRQLHRLGHAHSIEIWQEGQLQAGLYGLSLGRVFCGESMFSRIDNGAKLAMVALCQHFARHDGALIDCQMQNDFLATLGIEEWPRRQFLTTLAQLSRQPLAANCWQTGSILL
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_BURM9
Sequence: MAQTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKQPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGGYQRFSLDYVRRVLAQLKREHDGARVPAIAFTKGGGLWLEELAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDPTILFAPPEAIRAEARAVLDSYGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAGS
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UD2B7_HUMAN
Sequence: MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND
What is the function of this protein?
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10702251, PubMed:15472229, PubMed:15470161, PubMed:18674515, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:23756265, PubMed:26220143, PubMed:17442341).  Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15470161, PubMed:18674515, PubMed:23756265).  Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:2159463, PubMed:15472229, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:26220143, PubMed:17442341).  Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development (PubMed:10702251).  Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265).  Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515).  Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161).
What are the official names of this protein?
UDP-glucuronosyltransferase 2B7, UDPGT 2B7, UGT2B7, 3,4-catechol estrogen-specific UDPGT, UDP-glucuronosyltransferase 2B9, UDPGT 2B9, UDPGTh-2.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: FABH_BURCH
Sequence: MAQSTLYSRVLGTGSYLPPDRVTNQQLTDRLAKEGIETSDEWIVARTGIHARHFAAPDVTTSDLALEASRRAIEAAGVDPQSIDLIIVATSTPDFVFPSTACLLQNKLGIKNGGAAFDVQAVCSGFAYAMATADSFIRSGQHRTALIVGAETFSRILDFKDRTTCVLFGDGAGAVILSASEEPGVLGSALHADGSYSNILCTPGNVNRGVIDGSAFLHMDGQAVFKLAVNVLEKVAIEALAKANLAPEQIDWLIPHQANIRIMTSTCRKLGLPQERMVVTVDQHGNTSAASIPLALDAAVRDGRIQRGQHVLIEGVGGGFTWGASVFRF
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAHO_SHEEP
Sequence: LLLSTCVALLLQPPLGALGASLEPEYPGDNATPEQMAQYAAELRRYINMLTRPRYGKRDKEGTLDFLECGSPHSAVPR
What is the function of this protein?
Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2.
What are the official names of this protein?
Pancreatic polypeptide prohormone.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPA15_IPOBA
Sequence: MAKPNGIIYSSPKSPQHPKIYAKTQVIEHSTQSNGYLSMLRLKLSNKGFWRAYRAPSGYIATRGSSLRCHSAETRHAETEECVREYRDSSDTSSMQGKDKDPASLGKSGTPSPGLAEACKFVYNDAKFVNERAKNDIVLLSRGIMRLDARARQDVAFLGSEFLKLDARAREHTEKIDNDVKRKAERLHHVATILKNKAQSRLKNAADRHWSDGALEADLRRADFAAKQRAMEDALMALEFVKNIHDMMVSKMCNLKRSSLNPNKMTERITLEKNGKMLNFLPGEVSAERISAIQEAYWDIAAALSEADGIDYTDPEELELLVATLIDLDAMDGKSSVSLLAECSSSPDVNTRKALANALSAAPSMWTLGNAGMGALQRLAEDTTLNRCCCIENHQRIEEAVGNRGGGQLEVHGERKITRR
What is the function of this protein?
May be involved in the regulation of leaf senescence.
What are the official names of this protein?
Senescence-associated protein SPA15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the ATA15/OSA15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: U1_TIBVC
Sequence: MEQTWMITCKVEFRSSVMFELDYEDTVLNLLQALPTNQTNPAKFIINSLTIPLAVQNAFQNKDFWRDPTGSKGEFHLVIKVILDGLENNENDWADSITCHWLDQRSGFYVMVDSTFVGHKLSGEIMCTVDEKICECIEKFANIIPNKYNYYHHTNYRFHIQRYRVNISIG
What are the official names of this protein?
Protein U1.
What is the protein family that this protein belongs to?
Belongs to the tibrovirus protein U1 family.
Protein: MNMA_DEHMC
Sequence: MSDSSELVMVAMSGGVDSSVTAMLLLEQGYNVAGVSLQLKSNNEPYGNGYNLKLINRAREVAAALNIPHYVVDLSDIFSQRVIADFCQQYSQGRTPNPCIRCNYYVKIGALLNKIQDFKADYLATGHYARIVSDENGTHLLRGADGKKDQSYFLYTLPPESLSRLMFPLGQKYKKDIVRLATNMKLPVSQKESQDVCFIPDGDYKSFLATRMGFTPGKILDTTGKILGEHQGLPLYTVGQRQGLGLASNEKLFVSDMNADANTITVAGHDQLYTSRILLSNFIWRESGIPLDTSGMIVKVRYKAAPAEVKKISQSGDFYILELASPVWAATPGQAAVIYLDDMVLGGGIIESGGDTI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRGN_MOUSE
Sequence: MQVPVGSRLVLALAFVLVWGSSVQGYPARRARYQWVRCKPNGFFANCIEEKGPQFDLIDESNNIGPPMNNPVLMEGPSKDFISNYDDYGSGSGSGSGSGSGSGSGSGSGFLGDMEWEYQPTDESNIVYFNYKPFDRILTEQNQDQPEDDFII
What is the function of this protein?
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles.  Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes.  Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils.  Mediates processing of MMP2.  Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis.  Regulates the secretion of TNF-alpha and may also regulate protease secretion.  Inhibits bone mineralization.
What are the official names of this protein?
Serglycin, Mastocytoma proteoglycan core protein, Secretory granule proteoglycan core protein, gp600.
What is the protein family that this protein belongs to?
Belongs to the serglycin family.
What are the subcellular locations of this protein?
Cytoplasmic granule. Cytolytic granule. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T-lymphocytes from where it is secreted upon cell activation (PubMed:16046402). Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation (By similarity).
Protein: HXB7_BOVIN
Sequence: MSSLYYANALFSKYPAASSVFATGAFPEQTSCAFASNPQRPGYGAGSGASFAASMQGLYPGGGGMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDSAKAAGAKEQRDSDLAAESNFRIYPWMRSSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTSGPGTTGQDRAEAEEDEEE
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-B7.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MGRB_SALTI
Sequence: MKKFRWVVLGIVVVVCLLLWAQVFNIMCDQDVQFFSGICAINKFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LIPB_CAEEL
Sequence: MVYSSSSMSNTNIRRRSVPITIQKSRMDGFAEANQLLSSALEQLDDIIRNGNSTSRSTTTIGSAGPTPIIKKSFRDLLPPPPALRSTFSPRIMENGHSNLAHKQHINDDIDNGNADDERSSREINRQWISTDWKHRTDLGSDGSSGVESPPSDLPTSSSSLFSPPRVYQEFVKAIDEQTMTERPDLETRLKIMQWVAGRTSPSPSMSTVSCPEYPELQDKLHRLAMARDSLQLQVSVLSEQVGAQKEKIKDLETVIALKRNNLTSTEELLQDKYHRIDECQELESKKMDLLAEVSSLKLRYATLEREKNETEKKLRLSQNEMDHVNQSMHGMVVQQQLAHHTNGHSSGGYMSPLREHRSEKNDDEMSQLRTAVQRLMADNEHKSLQINTLRNALDEQMRSRSQQEDFYASQRNYTDNFDVNAQIRRILMDEPSDSMSHSTSFPVSLSSTTSNGKGPRSTVQSSSSYNSSLSAVSPQHNWSSAGAGTPRQLHPIGGNQRVNNITSAQYCSPSPPAARQLAAELDELRRNGNEGANHNYSSASLPRGVGKASSTLTLPSKKLSVASGTSVGELGGSMSSVAQPTPKRNYRAQMNRWINEKLRRKRAVSAPNLVESDDEIARGRNLNNATSQSNLKNFSRERTRSSLRNIFSKLTRSTSQDQSNSFRRGSAARSTSTARLGSTNHLGTVSKRPPLSQFVDWRSEQLADWIAEIGYPQYMNEVSRHVRSGRHFLNMSMNEYEGVLNIKNPVHRKRVAILLRRIEEDIMEPANKWDVHQTLRWLDDIGLPQYKDVFAENVVDGPLLLSLTANDAVEMKVVNAHHYATLARSIQFLKKADFRFNAMEKLIDQNIVEKYPCPDVVVRWTHSATCEWLRKIDLAEFTQNLLFAGVPGALMIYEPSFTAESLAEILQMPPHKTLLRRHLTSHFNQLLGPKIIADKRDFLAAGNYPQISPTGRVKVVKKGFSLTRKKAKNEICLEPEELLCPQVLVHKYPTGAGDNSSFESSNV
What is the function of this protein?
Involved in the regulation of synaptic function at neuromuscular junctions (PubMed:19290026).  Together with the liprin-alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse (PubMed:19290026).  Does not seem to be required for neuronal development (PubMed:19290026).  May regulate the disassembly of focal adhesions (By similarity).  Does not bind receptor-like tyrosine phosphatases type 2A (By similarity).
What are the official names of this protein?
Liprin-beta homolog, LAR-interacting protein beta.
What is the protein family that this protein belongs to?
Belongs to the liprin family. Liprin-beta subfamily.
Protein: PUR9_CAMJE
Sequence: MRALLSVSDKEGIVEFGKELENLGFEILSTGGTFKLLKENGIKVIEVSDFTKSPELFEGRVKTLHPKIHGGILHKRSDENHIKQAKENEILGIDLVCVNLYPFKKTTIMSDDFDEIIENIDIGGPAMIRSAAKNYKDVMVLCDPLDYEKVIETLKKGQNDENFRLNLMIKAYEHTANYDAYIANYMNERFNGGFGASKFIVGQKVFDTKYGENPHQKGALYEFDAFFSANFKALKGEASFNNLTDINAALNLASSFDKAPAIAIVKHGNPCGFAIKENLVQSYIHALKCDSVSAYGGVVAINGTLDEALANKINEIYVEVIIAANVDEKALAVFEGKKRIKIFTQESPFLIRSFDKYDFKHIDGGFVYQNSDEVGEDELKNAKLMSQREASKEELKDLEIAMKIAAFTKSNNVVYVKNGAMVAIGMGMTSRIDAAKAAIAKAKEMGLDLQGCVLASEAFFPFRDSIDEASKVGVKAIVEPGGSIRDDEVVKAADEYGMALYFTGVRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: CW15B_XENLA
Sequence: MTTAARPTFEPARGGRGKGESDLSQLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRSRDFRRELEERERVAVRDKNRDRPTREHTSSVSKKPRLDQIPAANLDADDPLTDEDADEDSDEDSDDDTAALLAELEKIKKERAEEQVRKELEQKAEEERIRMENILSGNPLLNLTGPAAQSQASFKVKRRWDDDVVFKNCAKGVDEMKKRQDKRFVNDTLRSEFHKKFMEKYVK
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome.
What are the official names of this protein?
Protein CWC15 homolog B.
What is the protein family that this protein belongs to?
Belongs to the CWC15 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYP1_STRAW
Sequence: MAQVQRMSRLMVKTLRDDPADAETLNHKLLVRADYVRRTAAGIWSWLPLGKKVLENVARVVREEMDAMGGQEVLLPALLPKEPYEATGRWEEYGPELFRLKDRKGAEYLLGPTHEEIFTQLVKDQCSSYKDLPVILYQIQAKYRDEARPRAGILRGREFLMKDSYSFDTADEGLAQSYALHREAYIKIFNRLGLDHRIVSAVSGAMGGSASEEFLAPAPAGEDTFVDCPACDYAANTEAVTFVAPAVESVEHPAVEELDTPDTPTIESLAEYLGVPASATLKNLLVKADGEIVAVGVPGDREVDLGKLGEHLAPAVVELVTAEDFEGRDDLVRGYVGPQGLEKVRYIADPRVAPGTAWITGANKINTHAKNVVAGRDFEVDDYLDVVVVEEGDPCPSCGTGLRLDRAIEIGHIFQLGRKYADAFQLDVLGKEGKPVRVTMGSYGIGVSRAVAALAEQTADEQGLCWPKEIAPADVHVVAAGKALQTELALDVAEKLGAAGVRVLVDDRAGVSPGVKFTDAELIGVPQILVAGRRSAEGVLELKDRKTGEREELTVEEAIARLSA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase 1, Prolyl-tRNA synthetase 1, ProRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARA_MYCTO
Sequence: MSKAVLVLEDGRVFTGRPFGATGQALGEAVFSTGMSGYQETLTDPSYHRQIVVATAPQIGNTGWNGEDSESRGERIWVAGYAVRDPSPRASNWRATGTLEDELIRQRIVGIAGIDTRAVVRHLRSRGSMKAGVFSDGALAEPADLIARVRAQQSMLGADLAGEVSTAEPYVVEPDGPPGVSRFTVAALDLGIKTNTPRNFARRGIRCHVLPASTTFEQIAELNPHGVFLSNGPGDPATADHVVALTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGHRGINIPVVDHATGRVAVTAQNHGFALQGEAGQSFATPFGPAVVSHTCANDGVVEGVKLVDGRAFSVQYHPEAAAGPHDAEYLFDQFVELMAGEGR
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: MKRN1_XENLA
Sequence: MAEAAAAPALLTSAASAGKAPLPAFPENPPVGVWTRHVTCRYFIHGVCKEGINCRYSHDLATSRSAMICRYFQRGCCAYGDRCRYEHNKPLQEDPTGDTCTAPSESLPEPSGNINSKAAELAASELASGGPRAQDWVNAVEFVPGQLYSGRAPEAYTQGTVKPDEGREEPADPELKKQLCPYAAMGECRYGENCVYLHGDPCDMCGLQVLHPVDTCQRSQHIKSCIEAHEKDMELSFAVQRSKDIVCGICMEVVYEKTNPSERRFGILSNCSHSYCLKCIRKWRSAKQFESKIIKSCPECRITSNFIIPSEYWVEEKEEKHKLIHKYKEAMSSKSCRYFDEGRGTCPFGGNCFYRHAYPDGRIEEPQPRQKSGMSSRYRIPSPSAGIDFGSLTSERAETRLRTRKTKL
What is the function of this protein?
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase makorin-1, RING-type E3 ubiquitin transferase makorin-1.
Protein: RL29_BUCAT
Sequence: MKALVGFRKKNKKDLYTELLQLLREQFNLRMQSVSGKLKQPHLLRKVRRNIAQVKTLLDSKEEIK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: COAA_SINMW
Sequence: MSIAAKDIEPADIPGNLQGGEYSPYHVFSAEEWSRFRADTPLTLTADEVQRLRSLNDPVDLDEVRRIYLSLSRLLSAHVEASQILFRQRTRFLSMSNETKTPFVIGVAGSVAVGKSTTARILAELLARWPSSPKVDLVTTDGFLYPNAVLQRESLMDRKGFPESYDIGALLRFLSAIKAGRPNVKAPTYSHLTYDVIPDQFQLVDRPDILVFEGINVLQSRDLPADGKIVPMVSDFFDFSIYIDAEESLIHSWYVNRFMRLRETAFQNPQSFFHRYATISEDAARAIAEGLWHNINLKNLHQNILPTRPRADLILQKGPSHLTQTVALRKL
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KMT5B_MOUSE
Sequence: MKWLGDSKNMVVNGRRNGGKLSNDHQQNQSKLQQHSGKDTLKTGRNAVERRSSRCHGNSGFEGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPSRSSRHISKADSFSHNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKNSDSQSVSSNTDADTTQEKDNATSNRKSSVGVKKSSKSRALTRPSMPRVPAASNSTSPKLVHTNNPRVPKKLRKPAKPLLSKIRLRNHCKRLDQKSASRKLEMGSLVLKEPKVVLYKNLPIKKEREPEGPAHAAVGSGCLTRHAAREHRQNHGRGAHSQGDSLPCTYTTRRSLRTRTGLKETTDIKLEPSPLDGYKNGILEPCPDSGQQPTPEVLEELAPETAHREEASQECPKNDSCLSRKKFRQVKPVKHLAKTEDCSPEHSFPGKDGLPDLPGSHPDQGEPSGTVRVPVSHTDSAPSPVGCSVVAPDSFTKDSFRTAQSKKKRRVTRYDAQLILENSSGIPKLTLRRRHDSSSKTNDHESDGVNSSKISIKLSKDHDSDSNLYVAKLSNGVSAGPGSSSTKLKIQLKRDEESRGPCAEGLHENGVCCSDPLSLLESQMEVDDYSQYEEDSTDESSSSEGEEEEEDCEDDFDDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
What is the function of this protein?
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:28114273, PubMed:24049080, PubMed:15145825).  In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity).  H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (PubMed:15145825).  Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions (PubMed:15145825).  KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (PubMed:16612004, PubMed:15750587).  Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823).  Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).  May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273).
What are the official names of this protein?
Histone-lysine N-methyltransferase KMT5B, Lysine-specific methyltransferase 5B, Suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1, Suv4-20h1, [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B, [histone H4]-lysine20 N-methyltransferase KMT5B.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin.
Protein: PYRR_STAAW
Sequence: MSERIIMDDAAIQRTVTRIAHEILEYNKGTDNLILLGIKTRGEYLANRIQDKIHQIEQQRIPTGTIDITYFRDDIEHMSSLTTKDAIDIDTDITDKVVIIIDDVLYTGRTVRASLDAILLNARPIKIGLAALVDRGHRELPIRADFVGKNIPTSKEETVSVYLEEMDQRNAVIIK
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: MPI_ECHMU
Sequence: MLRLKCASQRYDWGKVGVNSIVYKLQVASENPDISHVDLPYAELWMGTHPSGSSCLWDNPHVTLAAHIQENPASLGKPSLIYFGRRLPFLFKVLSVAKALSIQAHPDKKMAVRLHAEQPDLYKDGSHKPEMAIALTDFEALLGFRPLNQILAFIQAFPELAELTTLELPSPEEKRDVQPPSIKQLYSNLMRSSPEKVESTIKSLLNRFTTGSKSVCDPPLSILGVDLQEEDVQALVDLFLRLTQAFPGDVGCLSIFFLNYIRLKSGEAIFLKANTPHAYLSGDCVECMANSDNVVRAGLTPKFKDVERLLEMLDYTPLTDSLRLGATQPIPTPEGISMKSFIPPVSEFAVDVIQFDAESRGFSLPSVPTASILLFLHGQGTITCPSTGEACSQETKFGPGFVYFVPADMIVNLVSKEDRKGSLHAFRAYVNRK
What is the function of this protein?
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
What are the official names of this protein?
Probable mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI.
What is the protein family that this protein belongs to?
Belongs to the mannose-6-phosphate isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.