PharMolix/UniProtQA huggingface dataset:
Protein: RB11A_PONAB
Sequence: MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  The small Rab GTPase RAB11A regulates endocytic recycling.  Acts as a major regulator of membrane delivery during cytokinesis.  Together with MYO5B and RAB8A participates in epithelial cell polarization.  Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.  Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells.  Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane.  Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane.  Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity).  May also play a role in melanosome transport and release from melanocytes (By similarity).
What are the official names of this protein?
Ras-related protein Rab-11A, Rab-11.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle membrane. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis.
Protein: ZN668_MOUSE
Sequence: MEVEATEARSPGPCYKRSGRRYKCLFCTKTFPNAPRAARHAATHTPTDCTEEVREAQPKVDTEPKAEEASGDKVSASVAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAYGTLSKLKIHQRGHTGERPYACPDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSAAPVAGAGVGDAPAGLLGLPPESGGVVATQWQVVGMTVEHVECQDAGVGEAPSTLGDAGEVGGEETDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTHSSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGMPEEGSA
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 668.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ASCC1_MOUSE
Sequence: MDVLRPQIVTFDGRNYRKNPIQEKQYQHEEDEDFYPDSMEYSDEPCGAYEVAQTPHGFRATVSAPSLLYKHIVGKRGDTKKKIEVETKTSINIPKHGHEGEIVITGQHRNGVVSARTRIDVLLDTFRRRQPFTHFLSFFLNEVEVQERFLMFQEEVLRKCSKDRGVDSTIFQNPKKLHLTIGMLVLLSEQEIQQTCEILQRCKEEFINDISGGRPLEVEMAGIEYMNDDPAMVDVLYAKVHMKDGSNRLQELVDRVLERFQSLGLIVKEWTSVKLHATVMNTLLRKDPNAEGRYNLYTADGKYIFKERESFDGRNILKTFENFYFGSLRLNSIHISQRFTVDSFGNYASCGHVDFS
What is the function of this protein?
Plays a role in DNA damage repair as component of the ASCC complex.  Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.  In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin.  May also play a role in the development of neuromuscular junction.
What are the official names of this protein?
Activating signal cointegrator 1 complex subunit 1, ASC-1 complex subunit p50, Trip4 complex subunit p50.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Colocalizes with PRPF8 in nuclear speckles in the absence of DNA damage.
Protein: BAMD_VIBCH
Sequence: MKYQTLSGLLALSLLFGCSSSPDVVPDVPPSQLYSEAQTALQSGTWLTAIEKLEALDSRYPFGAYSEQVQLDLIYAYYKNDDLALGLATIERFTRLNPTHEKMDWVLYMRGLTHMAQDRNFMHDLFNIDRRDRDPEPVKAAFADFKKLLQRYPNSPYAEDAQRRMFALKNRLAEYDLATADFYLRREAWIAAINRTQELQKTYPDTEAARKSLEIQLEAYQQLGLTDAIERTKQLMQLNPL
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamD.
What is the protein family that this protein belongs to?
Belongs to the BamD family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: PYRH_YERP3
Sequence: MATNAKPVYQRILLKLSGEALQGAEGFGIDASVLDRMAQEVKELVELGIQVGVVIGGGNLFRGAGLAQAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDNYSWAEAISLLRHNRVVIFAAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVYSADPVKNPDATLYEQLTYQDVLEQELKVMDLAAFTLARDHNLPIRVFNMNKPGALRRVVMGENEGTLIAK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TP4AB_DICDI
Sequence: MDPGRSHIETIIESSTHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDASLFEGVKIHELCFKDGNVPPKDIIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIEDGMKPLQAVEFVRSKRKNAINSPQIKFLKEYKASKKAGCKIM
What are the official names of this protein?
Probable protein tyrosine phosphatase type IVA B.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor.
Protein: UBR2_YEAST
Sequence: MEDSDLSITNIRDFLTELPKLAKCEYSETTSYLLWKTLNLRLKHSDNDINWRSLVSILNSEAWENEKYRDILNGRKWRTLEFENDHHSVGNMHIGTACTRLCFPSETIYYCFTCSTNPLYEICELCFDKEKHVNHSYVAKVVMRPEGRICHCGDPFAFNDPSDAFKCKNELNNIPISNDNSNVTDDENVISLLNYVLDFLIDVTVSYKEEAEAHSSERKASSLMHPNQNSITDDIMEKHECEPLVNDENFVFFDNNWSNTRKEAHMEWAIQIEEEECNVHYMDLASTITRILNTPVEYAISITKALEDSHDVVTVLQSENFFEIDQIAKEFQKENIVVHVRKADDIFKRKLTDDLTDWLYSLCFKAATSLQNKYALRISMLDVWYSHFSKMRVSPTNTNPDFSKINLLGGFLISNEDSDESWFKPWSLENIEDERISKILTNYNERLIRAHSPNTVSHFYNFYGSRFQYIIINSINILSKKSKFKMLKIMASLFSLRDESRKFLAAQYIDVYLSVLYDAVASDAKECQVTLMSILGQYTFQDPSIANMTISSGFIERTIRFAFTLMAFNPEDLMSYLPISLYNGFKLPTETIRNRRTIICFKDLCTIMSANTVPEELLSNEAIFNAIIESFSEFSNVLPLKRETKEHVEVENFDFSAFYFFFSSILIMTDGYTRSISLVKDAAFRKQIVLKLLDVAQTREFESLTNSRKAISPDNASTNENDSNKATLSTVRETICNYVAETINFQVGVNTQYFFNPMSYLFKFVIQWSQCGRYEPIPASLTNYINLFEVFQDKQKALYISESALSTLVLIGQINVGFWVRNGTPITHQARMYTKYSMREFTYISDIFNVQFSMAMCNPDELMVTYLSRWGLKHWANGVPMYDYPDTETTVAVVNECILLLIQLLTEVRSLVMKSSKEGFERTFKSEIIHALCFDTCSYAQIVNCIPEHITKHPSFDIYLEKYANYTSPVSLTDNGIFVLKEKYKDEIDPYYIGLSSSRRYDVEKNIRLNMANLKKMKYEDTFVPAKKVKDLLKNTLFSGLYSISSVNTFGLFLKNTLDHIIKYDYDNLLPRVVHLIHLCVVNNLNEFMGILWHEYAIVDTEFCHYHSIGSILYYCLLKDNFSESHGKIREIFRYLMETAPHVNVNSYLREQTTSYTPGILWPTKEDKSHKDKEFERKKHLARLRKKKLMKKLAQQQMKFMENNSVDTSDISTPRTTSPSLSPTRINAENSSNTINSCCDDDCVFCKMPKDDDVFVYFSYQERNICDHGIDFTNPTDVNRINSLFSGKQTKDSAIQENPQDDDGTRLKFTSCEPVLRACGHGSHTKCLSGHMKSIRGIQNQTTKNIPLSYGSGLIYCPVCNSLSNSFLPKTNDIDKRTSSQFFMCIEKRSEAEENLDPMSSICIKAAMILGDLQGKKVTTIEDAYKVVNSVFINTISNTELRLRSHKKEGKIVNMERISSQCILTLHLVCELKSFIYKKFVNSKTFSSEISRKIWNWNEFLIKGNNVNLLLYMSQNFDNIDGGKTPQPPNLCIYEMFKRRFHQLLLLLARDMMRVNFYKDCRNKIKISSNGSEEPSTSFSYLFNTFKKYVDLFKPDDVRFDFTSLEKIKDFICSLLLESLSIFCRRTFLLFNIQYDDDGDGDNNNNRSNNFMDVKQREIELIFRYFKLPNLTHFLKDFFYNELTQNIERYNDGNDNLRIQQVIYDMVQNINTRAYPSPEHIQLIELPLNLSKFSLDNDEISNKCDKYEIAVCLLCGQKCHIQKSIALQGYLQGECTDHMRNGCEITSAYGVFLMTGTNAIYLSYGKRGTFYAAPYLSKYGETNEDYKFGTPVYLNRARYANLANEIVFGNMIPHIVFRLTDGSADLGGWETM
What is the function of this protein?
E3 ubiquitin-protein ligase which probably functions outside the N-end rule pathway, since it lacks the residues essential for the degradation of N-end rule substrates.  Mediates RPN4 ubiquitination and subsequent degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase UBR2, RING-type E3 ubiquitin transferase UBR2, Ubiquitin-protein ligase E3 component N-recognin-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the UBR1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_LEUCK
Sequence: MKELTSSEVRQMFLDFFASKGHEIVPSKNLIPQDDPTLLWINSGVATLKKYFDGSVIPKNPRITNAQKAIRTNDIENVGKTARHHTLFEMMGNFSVGDYFKAEVIPWAWELLTSPEWYGLDKDLLYVTVYPKDQEAKKIWLEKTDLPEGHIYEVEDNFWDIGEGPSGPDSEIFFDRGPAFQNLPDNDPEMYPGGENERYLEIWNIVFSQFNHLPGLTDNAQYPELPHKNIDTGMGLERLVSVFQNGRTNFDTDLFLPIIRATEKMSPDYTYDATKDSESNTSFKVIADHIRAITFAIGDGALPANEGRGYVIRRLLRRAVLHGQKLGIQGEFLTKLVPIVAEIMQSYYPEIADNTEKIQKTIAAEEKRFNATLTGGLSLLNDVIAKAKASGQQVISGADAFKLSDTYGFPLELTQEQAADEGLTVDVVGFNDALQAQRTRARAARSNDKSMGVQNAVLTDLKVPSDYVGWSETEVSNAAIVAIIGHDNQGVDALLANAEPGDSVQLVFDKTPFYAEMGGQVADQGEVLNKQGEVVARVTDTQSAPNGQHVHTVEVVTSFKLGDQVALKVNLARHVAISKNHTATHLLDQTLRNVIGGDVHQAGSLVEPEYLRFDFTHEGPVSEQNLEKIETMVNQVIANNLPITWVETDIESAKKMGAVAVFGEKYGDVVRVVSIGDFNKEFDGGTHAQTTAELGLFKIVSESGIGAGVRRIEAVTGLAALSQFKAEEQALKVIADSLKAQKLTDAPAKVEDLQVEIKTLQRHLTSVEAQLANAAAQDVFKDVKTQNGYQYITAQLQVSGMDGLRQVVDTWRENYPSDVLVLATHVDDKVSLIVAASPEANKKGFKAGDLIKAIAPKIGGGGGGRPDMAQAGGKNPAGINDAFSAVSTFLDELA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BMBP_THEPX
Sequence: MFRLTRLSNKPILSPIKEHEWEKEAVFNAAVIYEGNKFHLFYRASNNKFVLNTEKPEEKYKFVSSIGYAVSEDGINFERFDKPVLVGEIPQEAWGVEDPRITKIDNKYYMLYTGFGGRDWLDFRICMVWSDDLKNWKGHRIVLDEPNKDAALLSEKINGKYVLFHRRMPDIWIAYSDDLVNWYNHKIIMSPKSHTWESKKIGIAGPPIKREDGWLLIYHGVDNNNVYRLGVALLDLKDPSKVIARQKEPILEPELDWEINGLVPNVVFSCGAVEVNDMYYVYYGAADTHIGVAVIEKEKVKF
What is the function of this protein?
Probably involved in a salvage pathway for GDP-D-mannose biosynthesis (PubMed:25500577).  Catalyzes the reversible phosphorolysis of 1,2-beta-oligomannan.  In phosphorolytic reactions, prefers beta-1,2-mannobiose (beta-1,2-Man2) as substrate.  Produces alpha-D-mannose 1-phosphate, which is the precursor of GDP-D-mannose (PubMed:25500577).
What are the official names of this protein?
Beta-1,2-mannobiose phosphorylase, Beta-1,2-mannobiose:phosphate alpha-D-mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 130 family.
Protein: Y1366_LACP3
Sequence: MESWLFLLGILAIAIVGKNKSLIIGVSAVMVLKLIPQTQNFLKLLQTQGINWGVTVISAAIMVPIATGEIGFKELLNVIKSPAGWIAIGCGVLVAVLSAKGVGLLAMSPEMTVALVFGTIIGVVFLKGIAAGPVIASGLTYVILTVFNLVPGH
What are the official names of this protein?
UPF0756 membrane protein LSEI_1366.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NFIL3_BOVIN
Sequence: MQLRKMQSIKKEQASLDAGTNVDKMMVLNSALTEVSEDLTTGEELLLNEGSVGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKSTVSAFVDEHEPSMVASSCISVIKHSPQSSLSDVSEVSSLEHSQEGPVQNGCRSPESKFQVIKQEPMELESYAREPRDDRGAYRGAVYQNYMGNSFPGYSHSPPLLQVNRSSSNSPRTSETDEGAVGKSSDGEDEQQVPKGPIHSPVELQRVHATVVKVPEVNSSALPHKLRIKAKAMQIKVEAFDHEFDGTQKLSSPVDMTSKRHFELEKHTTPNLVHSSLTPFSVQVTNIQDWSLKSEHWHQKELNGKTQSSFKTGVVEVKDSGYKVSDPENLFLKQGIANLSAEVVSLKRLIATHQISASDSG
What is the function of this protein?
Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters.  Represses transcription from promoters with activating transcription factor (ATF) sites.  Represses promoter activity in osteoblasts.  Represses transcriptional activity of PER1.  Represses transcriptional activity of PER2 via the B-site on the promoter.  Activates transcription from the interleukin-3 promoter in T-cells.  Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF).  Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock.  Protects pro-B cells from programmed cell death (By similarity).  Represses the transcription of CYP2A5 (By similarity).  Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity).  Required for the development of natural killer cell precursors (By similarity).
What are the official names of this protein?
Nuclear factor interleukin-3-regulated protein.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. NFIL3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: UVRB_HELPJ
Sequence: MPLFDLKSPYPPAGDQPQAIEALTKSLKNNNHYQTLVGVTGSGKTYTMANIIAQTNKPALIMSHNKTLCAQLYSEFKAFFPHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIKVGEKRAYKSFLLKLVEMGYSRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALERNEIKRLDSVMLYAASQFAVGSERLNLAVKSIEDELALRLKFFKEQDKMLEYNRLKQRTEYDLEMISATGVCKGIENYARHFTGKAPNETPFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKLELELSQKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKSVVARGERVLITTLTKKMAEELCKYYAEWGLKVRYMHSEIDAIERNHIIRSLRLKEFDVLIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKTTQSMQKAFEITSYRRAKQEEFNKIHNITPKTVTRALEEELKLRDDEIKIAKALKKDKMPKSEREKIIKELDKKMRERAKNLDFEEAMRLRDEIAQLRTL
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODO1_PONAB
Sequence: MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPRSMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPSAELAWCQEEHKNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDIFKNFS
What is the function of this protein?
2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC).  Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC.  Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST).  Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids.  Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate.  Mainly active in the mitochondrion.  A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
What are the official names of this protein?
2-oxoglutarate dehydrogenase complex component E1, E1o, OGDC-E1, OGDH-E1, 2-oxoglutarate dehydrogenase, mitochondrial, Alpha-ketoglutarate dehydrogenase, Alpha-KGDH-E1, Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2- oxoglutarate dehydrogenase complex is required for histone succinylation.
Protein: ACPS_CHLTR
Sequence: MFGVGIDIIEIDRIRKSYQTYGDRFLKKIFTEGERVYCFSKSNPYASLAARFAAKEAVAKALGTGIGKLLKWKEIEMCRDSRQPQVVVPEALLCSLGVKRVLLSVSHSREYATAVAIAE
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_STRS2
Sequence: MGIKVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVALKSKAGRNNNGRITVRHQGGGHKRFYRLVDFKRNKDGVEAIVKTIEYDPNRSANIALVHYTDGVKAYIIAPKGLEVGQRIVSGPEADIKVGNALPLANIPVGTVVHNIELKPGRGGELVRAAGASAQVLGQEGKYVLVRLQSGEVRMILGTCRATVGTVGNEQHGLVNLGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNQK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: THIO_PSEAE
Sequence: MSEHIVNVTDASFEQDVLKADGPVLVDYWAEWCGPCKMIAPVLDEVARDYQGKLKVCKLNIDENQDTPPKYGVRGIPTLMLFKDGNVEATKVGALSKSQLAAFLDANI
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: BNP_CRODU
Sequence: MFVSRLAASGLLLLALLAVSLDGKPLQQWSQRWPHLEIPPLVVQNWKSPTQLQARESPAGGTTALREELSLGPEAALDTPPAGPDGGPRGSKAAAAAPQRLSKSKGASATSAASRDLRTDGKQARQNWGRLVSPDHHSAAGGGCGGGGGARRLKGLAKKRAGNGCFGLKLDRIGSMSGLGC
What is the function of this protein?
Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity.  Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity).
What are the official names of this protein?
Bradykinin potentiating and C-type natriuretic peptides, BPP-CNP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURI_MYCS2
Sequence: MSDRLAPIGIFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPYGPLTIPQIRAHSLAIGDDLVSRGVKALVIACNTASSACLRDARERYSPVPVVEVILPAVRRAVAATRNGRIGVIGTQATIASGAYQDAFAAARDTEVFTVACPRFVDFVERGVTSGRQVLGLAEGYLEPLQLAEVDTLVLGCTHYPMLSGLIQLAMGDNVTLVSSAEETAKDLLRVLTELDLLRPHPDDPSVTAVRRFEATGDPEAFTALAARFLGPTLDGVRPVRRHAGAGR
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: YLX7_SCHPO
Sequence: MSEDLFVSINFPNGKSVKQPIGLYINGEWHKSAETWETVDPSIEEVIAKVYLAGEKEIDYAVKSAKEAFKTWKKVPGSEKGELLMKLAELTEKHADTLAAIEAMDSGKPLVSNARGDVDGTIALLRYCAGWADKIYGQVIPTGPEKLAYAKRTPIGVCGQIVPWNYPLNMAGWKIAPALAAGNCIIIKSAETTPLSLLYFATLVEEAGFPKGVVNIISGLGTVAGSYMAKHPGIDKIAFTGSTKVGVIVQQLAASNLKAVTLECGGKSPFLVFEDADLDQAVKWAALGIMYNSGQICTSNSRIYVQDSVYDKFIELFKKHVIQDYIVGMPFDDNTVVGPVVNKTQYNRIKNYIEQGKKEGAKLVLGDEPLPLKQGYFISPTIFADCSENMTIVKEEIFGPVVAISKFKTEDEAIEKANNTTYGLAAMCFTKDLERAHRVSDELEAGMVFINSTENSDIQAPFGGIKMSGIGNELGSNGIEMYTQIKAVHINFNNKL
What are the official names of this protein?
Putative aldehyde dehydrogenase-like protein C922.07c.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HEM1_AZOSB
Sequence: MQLYALGLNHHTAPLAIRERVAFQPDRLDQALQALTDSRTVSEAAILSTCNRTELYFAAEQPQRAADWLAGFHQLPLAQVSPYLYSYPQRDAVRHVFRVASGLDSMVLGEPQILGQVKEAARRAEEAGTLGTLLHKLFQNTFAVAKEVRSTTAIGANIVSMAAAAVHLTGRIFERVSDQHVLFIGAGEMIELCAAHFAGAGPRSMTVANRTEARAEALAARLGAQTMRLDAIADALPRFDVVVSCTASPLPIVGLGMVERAVKVRRHRPIVMVDLAVPRDVEPEVGQLDDVFLYTVDDLAQVVDAGIESRQQAVVEAEGIIDQRVDGFLHWLHARDAVPTIRALREHAETLRRGEIERALRQLAKGEDPQAVLDALSHGLTNKLMHGPTRFLTQAEGEGQAEASRVVQQLFNLSRHD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: Y1866_MYCTU
Sequence: MLDLSDGCSAGGTDMVTRLLADLGADVLKVEPPGGSPGRHVRPTLAGTSIGFAMHNANKRSAVLNPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVALSITDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATAAVQAAWAVLVAYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGIRSTGRWRGRPKNQDAYPIYPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQDPKYDVIGARLAAWPQISVLVAKLCAEKTMKELVAAGQALGVPITAVLTPSRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRAGFRTPAPAAGQDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDLGAEVIKVESADHPDGLRQTRVGDAMSESFAWTHRNHLALGLDLRNSEGKAIFGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNRGPWSTRMGYGPLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVVGRVGALLALAALIHRDRTGGGAHVHISQAEVVVNQLDTMFVAEAARATDVAEIHPDTSVHAVYPCAGDDEWCVISIRSDDEWRRATSVFGQPELANDPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAGVAAGPMNRPSDILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQAPQRPAPLPGQDSVQICRKLLGMTADETERLINERVMFGPAVTA
What is the function of this protein?
Probable CoA-transferase.
What are the official names of this protein?
Probable CoA-transferase Rv1866.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family.
Protein: Y1140_PSEPW
Sequence: MSVSVCPCGSGNLLDACCGHYHAGTPAPDAQALMRSRYSAYVLGLIDYLVATTLPAQQAGLDRNAIAAWSAQSTWLGLEVENAEVLGGQPEHAFVTFTARWHDLEGDHQHRERSAFVQHDGRWYFIDPTVELKAGRNDPCPCNSGQKFKKCCASYWGNRA
What are the official names of this protein?
UPF0225 protein PputW619_1140.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.