PharMolix/UniProtQA huggingface dataset:
Protein: CNTN2_HUMAN
Sequence: MGTATRRKPHLLLVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVENMAVRPAPHPGTVISHSVAMLILIGSLEL
What is the function of this protein?
In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region.  May be involved in cell adhesion.
What are the official names of this protein?
Contactin-2, Axonal glycoprotein TAG-1, Axonin-1, Transient axonal glycoprotein 1, TAX-1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. Contactin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons.
Protein: UL92_HHV8P
Sequence: MKSVASPLCQFHGVFCLYQCRQCLAYHVCDGGAECVLLHTPESVICELTGNCMLGNIQEGQFLGPVPYRTLDNQVDRDAYHGMLACLKRDIVRYLQTWPDTTVIVQEIALGDGVTDTISAIIDETFGECLPVLGEAQGGYALVCSMYLHVIVSIYSTKTVYNSMLFKCTKNKKYDCIAKRVRTKWMRMLSTKDT
What is the function of this protein?
Plays an important role in the expression of late genes (PubMed:25810551, PubMed:28336944).  May play a role in viral replication (PubMed:15163752).
What are the official names of this protein?
Protein ORF31.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL92 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Mainly localizes in host nucleus and partially in host cytosol.
Protein: RL2_AFIC5
Sequence: MALKTFNPTTPGQRQLVMVDRSALYKGKPLKKLTEGKHSNGGRGNTGRITVRFRGGGHKQTYRLIDFKRTKVDVPATVERLEYDPNRTAFIALIKYADGELSYILAPQRLAVGDTVVAGSYVDVKPGNAMPMGNMPVGTIVHNVEMKIGKGGQMARSAGTYAQIVGRDHDYVILRLNSGEQRMVHGRCMATIGAVSNHDHMNTSIGKAGRTRWLGRRPHNRGVVMNPIDHPHGGGEGRTSGGRHPVTPWGKPTKGKKTRSNKSTNKFILISRHKRKKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: VEGFA_RAT
Sequence: MNFLLSWVHWTLALLLYLHHAKWSQAAPTTEGEQKAHEVVKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNVTMQIMRIKPHQSQHIGEMSFLQHSRCECRPKKDRTKPEKKSVRGKGKGQKRKRKKSRFKSWSVHCEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
What is the function of this protein?
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.  Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.  Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin.  May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis.  Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).  Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
What are the official names of this protein?
Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
What are the subcellular locations of this protein?
Secreted. Note=VEGF-A120 is acidic and freely secreted. VEGF-A164 is more basic, has heparin-binding properties and, although a significant proportion remains cell- associated, most is freely secreted. VEGF-A188 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin (By similarity).
Protein: RS3_SORC5
Sequence: MGQKTHPYGFRVGVIKTWSSKWYEDGAAYQKWLHQDIRIKRAIKQYLYNANIAGVEIERAANRAKVIVFTARPGMVIGKGGKGIETLKSGNVGTASKGETLFPGVSSFTDNEVFIDVQEVRKAETNAQLVAENIATQLERRIAFRRAMKKAVSTAMKFGAKGIRVRCAGRLGGSEMSRVETYREGRVPLHTLRADIEFGLAEARTKVGIIGVKVWMFKGEVLQRKARRIQ
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: NADD_XYLFT
Sequence: MPSLHVFYGGTFDPVHVGHLAIARAAHAALQAPIALIPSADPPHRPTPGSSSMDRLRMLQLAVSKEPGLSADPRELQRAARQNRSSYTVDTLTEVRSELGPKTSIIWLLGADAFVNLSNWKDWQMLPELTHLVIANRPGITLQTQLPPKMATVFNHRWVQDPATLRKTPHGHLWLLNQHPNPSSASKVRAAISAAAHWEADLTPEVAQYIRTHGLYGIHDIN
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: TYSY_PSYIN
Sequence: MKQYLGLCQRIVDKGIWIENQRTGKRCLTVINADLEYDVGNNQFPMITTRKSFYKSAIAELIGYLRGYDNAADFRKLGTKTWDANSNLNNAWLNNPYRKGEDDMGRVYGIQGRSWAKPDGGFIDQLKKVVDDLSNGIDDRGEIVTFYNPGEFEMGCLRPCMHTHTFSLLGDTLHLTSYQRSCDVPLGLNFNQVQVFALLALMAQITGKKAGMAYHKIVNAHIYEDQLALMRDVQLPRLPFASPQLKINPKIKSLQDLETWVTMDDFEVEGYQCHDAIKYPFSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_TREPS
Sequence: MYSAHTPWYDGQVMDYPRRTIACGELRRCHVGTVVVLNGWVHRKRSHGTVSFFNMRDRSGIVQVIVSQEENASLWSTVNRIRLECCLAVEGVVRERPPSMINRALHTGEVEVHARTLYVLSENAVLPFRVDDVVHAHEDIRLKYRYLDLRSQRMQERIALRSRVALAIRQFLSMKGFIEIETPTFICSTPEGARDFVVPSRVCPGRFYALPQSPQLYKQLLMVAGFDRYFQLARCYRDEDARGDRQPEFTQIDLEMSFVSRDDVMRVNEDMLRYVFRTSIGVELPTFFPRLTYAQALDQYGTDKPDMRFKPVLQNADFMGMLGTFTPFEEVVAQGGSIRALVLPGKARCYSRRQIEALESIARAHEAHHLFWLKATGGGLEGGIARFFAGVESEVRRRLSAQDEDLLLFVADCRHRVCCVALGAVRSALIRDESFPEKELFSFVWIVDFPLFEWNPAENKWDPAHHMFSAPQEQYLETLEQDPGSVKGDLYDLVLNGYELASGSIRIHDTQLQKRIFKIVGLDPEEAGEKFGFLTEAFKYGAPPHGGIAHGLDRLVMLMTGSESIRDVIAFPKNTLAASPLDNCPSVLDKRQLDELHLTVHV
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOH_NOVAD
Sequence: MTEFFMGLGLSYEWAWGISTIAGILLIALPLMLGVAMIIYADRKIWAAMALRRGPNVVGPLGLLQSFADGLKVFLQETIIPTAANKGLFLIAPIITFTVALMAWAVIPFNSGAVLANINVGLLYVLAISSLGVYGVVIAGWSSNSKYPFFSAMRASAQMISYEVSIGFILICVVLWAGTFNLNDIVKAQQSHVWIINGFVANPLLFPMWVMFLISGMAETARAPFDLTEAESELVAGYQTEYSSMAFALYWLGEYANVLLMCALNAVLFWGGYLPPLDIPVLYLVPGFVWLLLKILFFFFIFSWVKATVPRYRYDQLMRLGWKVFLPVSLLFVFLVSGYLMATGHFA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACKR1_SAPAP
Sequence: MGNCLHQAELSPSTENSSQLNLEDLWDFPYNGNDSFPEINYDASLEAAAPCYSCNLLDDSSLPFFILASVLGILASSTVLFMLFRPLFRWQLCPGWPVLAQLAVGSALFSIVVPILAPGLGNTRSSALCSLGYCVWYGSAFAQALLLGCHASLGPKLGAGQVPGLTLGLTVGLWGAAALLTVPITLASGASDGLCTPIYSTELKALQATHTVACFAIFVLLPLGLFGAKGVKKALGMGPGPWMTILWIWFIFWWPHGVVLGLDFLVRSKLLLLPTCLAQQVLDLLLNLAEALTIVHCVATPLLLALFCHQATRTLLPSLPLPERWSSPVDTLGSKS
What is the function of this protein?
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor.  Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines.  Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC.  May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).
What are the official names of this protein?
Atypical chemokine receptor 1, Duffy antigen/chemokine receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).
Protein: RS4_STRGC
Sequence: MSRYTGPSWKQARRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFTYGVGEKQFRNLFVQATKIKEGILGFNFMLLLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSYRVTPGQVISVREKSLKVPAILEAVEATLGRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RL19_CLONN
Sequence: MLDIIKAIEAEQVKTDITEFNVGDTVRVNVRIKEGNKERLQAFEGTVIKRQNGGIRETFTVRRVAYGTGVERTFPVNSPMLESIKVVRRGKVRRSKLYYLRNRVGKAAKVKEALNR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: SERC_COXBN
Sequence: MSRVYNFSAGPAAIPEEVLFTVRDELLDWHGIGMSIAEVSHRGEEFIGVAEEAERDLRELLAVPESYHILFLQGGSRLQFAMVPMNLLANHKKAVYIDSGVWSNLAIREAKNYCDPHLATNAKELNYTGIPDQATWDMPNEAAYFYYVDNETVNGIEFPFIPDTDLTLVCDMSSNLLSRPFDVSRYGLIFACAQKNMGLAGLTIVIVHDDLLKRSPLPTTPSYLQYALHAKERSFINTPPTFAWYLAGLIFKWVKNQGGVAVLAERNQRKAAKLYKFIDKSNFFDNPINPTYRSRMNVIFRLADEILNSLFLKEATENGLANLKGHRLLGGMRASIYNAMTEEGVDALINFMGQFEKRHG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LTN1_SCHPO
Sequence: MKKKSTDLYGRKNPGMQSMSGSFSSLQIALDESSSNFSTIYEPPDLSGLDAEMIVIVKNLQKRDIVTKCRALQDLIQWNDPSQFDNEQFLNALAVLFPRLSIEVERHVRLKIFVFMSVLSSALQKKLAPWLKFYITPWVMGFFDSDRAVSVSAKDSFKNLLSEEKWPHVWLKFGSTIAPIVTDVFLHEDKESLTDLRFFSNEEAESKVTRVKSSCLLTLSFLFKQTADLENLETDKKIDKQTFKSSLYENLSTLFKSDEFWSLVSSPQDGVTVSLSDLLLIILKYDKPFVTQYKEKYFKRVSRMISRLTSLTCVPMLRLLSNMISNFPNEVHQFANDSKRPLSKLFSNLITKRISLPNSGFYTSLLNLFKSIGAMQLVPSIESVDELCDAFLETANQEQRFLSTEVYDCLLNFLSFVYTDSSDPQIKDHVRDRLRTIFTRYFKGEFVLRCSTSDFDHCLQSVFDKNSDFASLWNEVLFGFFNDESMDIETIPFDSLSRNLSLTVQTVLYLKNRNFQTGNEVMSILGPCLSFLMKLSTHKNERIACLSASQLITVCHIFSDTTLIKPVKELFQKYLVNDLPSSILKLGPQSPAFTLLRDILLLLKDYADLSEPWENVANQFTVSFDELENIRVLNSLPSLFADGKLRGKISLVKTLVEYYDTAVFAIMQNPGNDWDMIRACIGSKEILVPEETIKNILFTTLEYFLTNDWVDNHLIILCASLHSLKAHLPTIFDENKSLYSLLPVILFSKPEDDGHVAAHFESIFSLLKEKALEDSGFSLKLCSEVQEWSLNKVLNGSINEKLAADKCVLVFNSFGKLPSNFFTFPASFWDAKISSCIPFFSNKLFIDQDFILGFLDLVASEPINVDMTDVGTQFVHIFHASLYTLYYVETTGCDGDALFNLTFAYLLIRIYLQNGIQSIIDVPIRDAGIFVESFECYFKGEVVKFMRDKDALTVLNELLIDDIDGKMPVLFKRFKNLSSAENTTSFSIFAAQGLTDFLIVVSNLLEMDEKHVDVVLGKLGLSSSKSPIFVSSILEGLKPLEVDSEIIQRIRFKAVNDLTGKLHSANEVSKSLLILNAATTQQITEKPLLPITRCRLFLENITNWCSESGIKSLELLPVCCFLRFMYYFLPTVFSLSGSYWNSIFDYIKYAMKMSVVDAPIVKSFELFALRLYNALSKNYEMNSDIKDCIVESNESMNYLLLKRFLFTHESTLRNSVTARMCNQYLVKLLENCPGKVVRSFQYQEFFPSLCNSNDLQMESVCMKFLREKLSHELKELTVYYMVESDYEPDVSLCPELLSLAIDFPGDPFVMVSKMEKYEHALRVYLLVWDLIFYHFEETTYNIKLSIINQLHAMDLLRPLLNTLVEILNLSYDRPINVDKYPKIDYNLMDYSSATDRIRCLAIHIYYQCLRHLSSSVRSYWSEVKNRAFTSTVESFTGYNVSPLLISASLDDVERSIESEDFQSVGDVNVKVNRNTREISFIYNVDEHKLEMAIKIPSVYPLQNVQVEGIERVGVNERQWRSWILASQSILSSQNGSITDALLVLKKNISMHFEGVEECAICYSVLSVERTLPNKRCGTCRHKFHASCLYKWFKSSNSSRCPLCRSSFTFV
What is the function of this protein?
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.  Ubiquitination leads to cdc48 recruitment for extraction and degradation of the incomplete translation product.
What are the official names of this protein?
E3 ubiquitin-protein ligase listerin, RING-type E3 ubiquitin transferase listerin.
What is the protein family that this protein belongs to?
Belongs to the LTN1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: HSP30_ONCTS
Sequence: MLCSRGFQSSLSPLMDFYWPVRSLWPEVRPLLSQRDLLQRNLLEVKSSLELMAKLQQQIFEELDNVPSSLTIQPVSYKHDKDGEGFALTLDTKDFSPEELSVKQVGRKLRVSGKTEKKLDDGEGSYSYRCQEFRQEFDLPEKVNPETVTCSLAHDGKLHIQAPKNTLSGEEEVAERVVPINCSLDVKTPQFLSKTEGSITDTQKKQENTISKED
What are the official names of this protein?
Heat shock protein 30, HSP 30.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: PDS5E_ARATH
Sequence: MGPLVEATEFSKEQALTDAAENLLKPHFSTDATLSLLEVMESLLATVEQDLSSSVQKALHPPMRALVSADLLRNPDSDVRVSVVSCLTEIMRITAPEAPYNDEQMKDIFQVTIEAFEKLADASSRSYRKAEVILETVAKVRSSLVMLDLECDDLVLEMFQRFLKIIRPDHPQLVLVSMETIMITVIDESEEVPMDLLEILLTTVKKDSQDVSPAALTLVEKVLSSCTCKLQPCIMEALKSSGTSLDMYSPVVSSICQSEFATTQAHNDVKPKDNEADEKISEGQVVPSDSLEDKLNLGLSRKGTRSKRSARGGTRRANGDEKVITANEGLSESTDAETASGSTRKRGWKPKSLMNPEEGYSFKTSSSKKVQEKELGDSSLGKVAAKKVPLPSKVGQTNQSVVISLSSSGRARTGSRKRSRTKMEETDHDVSSVATQPAKKQTVKKTNPAKEDLTKSNVKKHEDGIKTGKSSKKEKADNGLAKTSAKKPLAETMMVKPSGKKLVHSDAKKKNSEGASMDTPIPQSSKSKKKDSRATTPATKKSEQAPKSHPKMKRIAGEEVESNTNELGEELVGKRVNVWWPLDKKFYEGVIKSYCRVKKMHQVTYSDGDVEELNLKKERFKIIEDKSSASEDKEDDLLESTPLSAFIQREKSKKRKIVSKNVEPSSSPEVRSSMQTMKKKDSVTDSIKQTKRTKGALKAVSNEPESTTGKNLKSLKKLNGEPDKTRGRTGKKQKVTQAMHRKIEKDCDEQEDLETKDEEDSLKLGKESDAEPDRMEDHQELPENHNVETKTDGEEQEAAKEPTAESKTNGEEPNAEPETDGKEHKSLKEPNAEPKSDGEEQEAAKEPNAELKTDGENQEAAKELTAERKTDEEEHKVADEVEQKSQKETNVEPEAEGEEQKSVEEPNAEPKTKVEEKESAKEQTADTKLIEKEDMSKTKGEEIDKETYSSIPETGKVGNEAEEDDQRVIKELEEESDKAEVSTTVLEVDP
What is the function of this protein?
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex (PubMed:26648949).  Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin (PubMed:26648949).  May couple sister chromatid cohesion during mitosis to DNA replication (By similarity).  Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (PubMed:26648949).
What are the official names of this protein?
Sister chromatid cohesion protein PDS5 homolog E, Precocious dissociation of sisters protein 5-E, AtPDS5E.
What is the protein family that this protein belongs to?
Belongs to the PDS5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BIOB_XANCB
Sequence: MSVVVRHDWDRKELHALFALPFPELLHRAASVHRAHFDPAEVQVSTLLSVKTGGCPEDCAYCPQAQRYDTGVSAQKLMDTEDVVAKARQAKAAGASRFCMGAAWRSPKDRDIPKVAAMIREVKAMGLETCATLGMLDAGQARALKDAGLDYYNHNLDTAPDYYDSIIHTRQYQDRLNTLEHVRDVGLKTCCGGIVGMGETREHRVGLLHALATLPAHPDSVPINQLVQVPGTPLHGTEPLDAFEFVRMIAVARIAMPKSMVRLSAGREAMSDELQALCFLAGANSIFYGEKLLTTGNPDTERDQGLFQRLGLRPMQITVDAAEHDHPGTVHADITCGAACEHAA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: TYSY_RHOPA
Sequence: MIQYQDLLERILSDGAEKHDRTGTGTLSVFGHQMRFDLAAGFPMLTTKRLPLKAIVHELLWFLQGDTNIKYLHDHGVTIWDEWADANGDLGPVYGAQWRSWPTADGGSIDQIANVVEMIKRNPDSRRLMVTAWNPADVEKMALPPCHCLFQFYVANGKLSCQLYQRSADVFLGVPFNIASYALLTLMVAQVTGLKPGEFVHTLGDAHLYSNHLEQARLQLTRAPRALPVMTINPAVKDIFGFRYEDFTLTGYDPHPHIKAEVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_AFIC5
Sequence: MRIIVIAVGRLKQGPERELAERYRERFESLGRKLGFRGLDIVELPESRHADATGRIAEEANAIAAHIPEHAAVVALSERGDNLDSATLARHLGRWRDDSVPCAVFLIGGADGLSAELSRVAKIRLAFGKATWPHQIVRILLLEQIYRAGTILAGHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_CHLPD
Sequence: MELSRSAAWSALVFHKHEVDKKTMRDMFAGDSDRFVKFSLSWKEMLLDYSKNRITSRTMELLLELAHSAGVDEKRQQMFQGAPINFTENRSVLHTALRRPPGYVLEVDGLNIGDEIAGVLFQMKNFCEKVISGKWKGYTGKSITDVVNIGIGGSDLGPYMVTEALKPFAHGGLDVHFVSNIDGTHIRETLKRLDPETTLFIIASKTFTTQETLTNAMSAREWFLARAVEEEYIKKHFAAVSTNQEKVVEFGIDDANMFRFWDWVGGRYSLWSSIGLSIALYLGFNRFEELLAGAHAMDEHFLNEPFNRNIPVILALLGIWYRNFFDAASHAVIPYDQYLHRFPAYLQQLDMESNGKRVDENGHTVTHATGPVIWGEPGTNAQHAFFQLLHQGPDLIPADFIVPLKSQNPSGEHHDMLLANCFAQTEALMKGKTEQEVRAELSDAGYDEADIQKLFQHKVFSGNRPTNTILVHELNPFMLGSLIAMYEHKVFVQGVIWRINSFDQWGVELGKQLARTILPEIQSAEAVTAHDASTNALINMARTFREENIRKESAQLSFF
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSV2_CANAL
Sequence: MVLAHSINTNPNTNTNTNNTSTTSSTTTIPNDSKILCINFNQDQGCFAISHEQGFLVYNTDPIELRVKRNFIVNSHTTSSRSNHSNGSNSNNNHRNNSTGSNGSVSSSGSNNETTLGYKSTHKSASGSGSGSGSGIGHISMLHRTNYLALIGGGENPKFPINKLIIWDDLKRKTSLSLEFDTPVLNVLLSRVRIIVVLIDQIIVYGFAAPPKKFQTFNTINNPLGIADLSVNSQQSNVHLYNNYSSNSAQAQVSGTTTTTHYDFSKRKSLSPTNSSNSSSTSLKENGTNLTTYPSPSSTTSASASVATITNTPEAATTANPTTATTTATTTATTTTTTTSAKPLVNGIGSSYQTLAFPGRSMGQIQIVDVGNNHHSGTNIKPTINIIKAHKSNIRCLCLNRTGTLIASASITGTIIRIHSTRTTALLYEFRRGIDRAIITSMKFSHDDSKLAVLSDKHTLHVYNIDETQYPNDGGSGGTKDGGGGGRGSKNRHHLLNGLLPYLPNYFQSTWSFCSVNTNKYHTSDLEDNSQQQQQQWVANGTGGGGVDEGVIGWSGNDSIIIIWKLKKIWEKYVIVETENHQYDLIRSSWKRLDS
What is the function of this protein?
Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
What are the official names of this protein?
SVP1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Vesicular and vacuolar.
Protein: SURE_METS3
Sequence: MKALISNDDGVNATGILAAKNAIEDLCEVCVVAPETQQSGIGHAITLYDPLRINPTTLRDKSQAYGVTGTPTDAVTFGLFEIMGEKPDIMISGINTGFNIGKAELTTSGTIGAALEAASFGIPSIAISQEVTRDYIKFENGTVDIDFSFAGKMLRKLVKIVFKKGLPDGIDLLNVNIPENPVDEEFEVAKLGNRMYTPIIQRRLDPRGKPYYWIGGDPYNSDCEGTDGHCLKKLNKATITPLTIDLTGEMDLIKEWLK
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.