PharMolix/UniProtQA huggingface dataset:
Protein: MED29_XENLA
Sequence: MAMLLNQAQPPQTRDGGGTQGASLGPGVPVGQQQLGLQQQQQDFDPVQRYRMLIPQLKESLQNLMKIAAQNLAQNTNIDNGQKSADGPVQRFDKSLEEFYALCDQMELCLRLAYECLSQSYDSAKHSPTLVPTATKPDAVQTESLPYTQYLSMIKSQISCAKDIHNALLECSKKIMGKTPNTQGGL
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 29, Intersex-like protein, Mediator complex subunit 29.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 29 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VAPC6_MYCBO
Sequence: MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAATQRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.
What are the official names of this protein?
VapC ribonuclease Mb2004c, RNase Mb2004c, Toxin Mb2004c.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: TBA1_PELFA
Sequence: MRECISIHIGQAGIQVGNACWELYCLEHGIQPNGQMPADNTTGGGDDAFNTFFSETGAGKHVPRAVYVDLEPTVCDEVRTGSYRQLYHPEQIISGKEDAANNYARGHYTIGKEIVDIVLDRIRKLSDNCTGLQGFLVFHATGGGTGSGLGSLLLERLSVDYGRKSKLSFAITPAPQVATAVVEPYNSVLSTHALLEHTDCTFCLDNEALYDVCRRNLDIERPTYTNLNRLVAQVISSLTASLRFDGALNVDVTEFQTNLVPYPRIHFMLTSYAPIISAEKAYHEQLSVAEITNSVFEPAGMMTKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTAVPGGDLARVQRAVCMVANTTAIAEALSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLVALEKDYEEVGAETADGDGEEEEFGEEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-1 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: IF2_PSYIN
Sequence: MSDMSLKDLAKDLNKSEEILVKQFADAGIKKSASDKVSLAEKQTLTSFLQKQHGGESKTKMTLQRKTKSTLNVKGSTGQAKAVQVEVRKKRTYVKRSDSETQETQAAELADQQAANDKLQAEIEAKKLLVEKALAEKLAAKKEADEKAKKAAAANKEKQTAVKSEKTAEQIASEKESAALLKKADQEASAKAEKETAQQAADAKKLVEENSARWAEEETARKKAAEGGDYHITSSKEAQAAEDVLDSKAEGPSRRKKKKKAPVEEKFQGRRTRRGKKQRPATPSALQQAFEKPAAPVERNVRIGETITVAELANKMAVKATEVIKAMMKMGAMATINQVIDQETATIVAEEMGHKVILTKENELEEAVMAEAQQGGDRTSRAPVVTIMGHVDHGKTSLLDYIRRAKVADGEAGGITQHIGAYHVETDKGMISFLDTPGHAAFTSMRSRGAKATDIVILVVAADDGVMPQTIEAIQHAKAAKVPLIVAVNKIDKEGADFDRVKSELSQHNIISEEWGGENIFTYVSAKVGTGVDGLLESILLQAEMLDLSAVAKGPAAGVVIESRLDKGRGPVASILVQHGELKLGDILLCGLEYGRVRAMRDENGKPIEVAGPSIPVEVLGLSGVPMAGDEATVVKDEKKAREVALYRQGKFRDIKLARQQKAKLDNMFANMEAGEVSELNIVLKADVQGSLEAICESLNKLSTDEVKVNIIGRGVGGITETDASLASASGAIVIGFNVRADASARKLIENEGVDLHYYSIIYGLIDEVRAAMSGLLAPEYRQEITGIADVREVFKSPKIGAIAGCMVTEGTIKRNNPIRVLRENIVIYEGVLESLRRFRDDLSEVRNGMECGIGVKNYNDVRVGDQIEVFETIEIKRTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMED4_MOUSE
Sequence: MAGVGVGPLQGMVRFGLLVLTVCAACARGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
What is the function of this protein?
Involved in vesicular protein trafficking, mainly in the early secretory pathway.  Involved in the maintenance of the Golgi apparatus.  Appears to play a role in the biosynthesis of secreted cargo including processing.  Involved in endoplasmic reticulum stress response.  May play a role in the regulation of heat-shock response and apoptosis (By similarity).
What are the official names of this protein?
Transmembrane emp24 domain-containing protein 4, Endoplasmic reticulum stress-response protein 25, ERS25, p24 family protein alpha-3, p24alpha3, p26.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: GIP3_PHYSO
Sequence: VLTLEKPSKFAPIKLPKADGSDIFPRVWSKVMGWGVTSYPNGKPSNELQSVDVRVWGDNACENKLGVDKSSLCAGGEAGKDSCVGDTGDPLIKENGRGDADDILLGLSGWGTGCGDKDMPSVYSRVSAGIEWINSVIKK
What is the function of this protein?
Secreted effector that suppresses host plant glucan elicitor-mediated defense responses (Probable).  Targets host endoglucanases and inhibits the endoglucanase-mediated release of elicitor-active glucan oligosaccharides from P. sojae cell walls (Probable).
What are the official names of this protein?
Glucanase inhibitor protein 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RO60_HUMAN
Sequence: MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQEPMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKTFKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLPMIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTGALDVIRNFTLDMI
What is the function of this protein?
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853).  Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853).  Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853).  May play roles in cilia formation and/or maintenance (By similarity).
What are the official names of this protein?
RNA-binding protein RO60, 60 kDa SS-A/Ro ribonucleoprotein, 60 kDa Ro protein, 60 kDa ribonucleoprotein Ro, RoRNP, Ro 60 kDa autoantigen, Ro60 autoantigen, Sjoegren syndrome antigen A2, Sjoegren syndrome type A antigen, SS-A, TROVE domain family member 2.
What is the protein family that this protein belongs to?
Belongs to the Ro 60 kDa family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: PURA_LIMRD
Sequence: MSSVVIVGSQWGDEGKGKMTDYLSQEADVVVRSQGGNNAGHTIAFDGKKFALRLVPSGIFAKDKLAVIGNGVVINPPALLKELHYLQDNGIDISGLRISSRSHITFPYHILLDKCQEEAKGDHKVGTTKNGIGPTYMDKVSRVGIRMCDLLEKDTFKEKLERNLAEKNELFTKLYHVDPISFDDIFESYYEYGQELKQYVTDTAQIVNDALDQDKKVLFEGAQGVMLDVDQGTYPYVTASNPIAGGVCTGVGVGPNKIETVVGICKAYSTRVGAGPFPTELTDEIGDQIRETGHEYGTVTGRPRRVGWFDSVAMRHARRVSGISCLSLNLLDVLTGLKTVKICTSYKLDGKQIDYYPASLKELERCEPVYEELPGWDEDITGAKKFEDLPINAQNYLKRVSELSESPLATVSVGADRIQTIIVKDPWEFAHK
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_PHOPR
Sequence: MTDQVQDENKLIAERRAKLDMIRKNCKANGHPNDFRRDSLAADLQATFGEKTKPELEEEGHIVAIAGRVMAKRGPFLAIQDVSGRIQAYADKTVQKELKEKYSGLDIGDIIGVKGQLHLSGKGDLYVTMDNYELLTKALRPLPEKFHGLTDQETRYRQRYVDLIVNEDSRNTMIMRSKVVSAIRNFMMKKDFMEVETPMMHVIPGGATARPFITHHNALDIDMYLRVAPELYLKRLVVGGFERVFEINRNFRNEGLSPRHNPEFTMMEFYMAYADYNDLMDLTEEMLSSIATDLHGSPKLPYGDAIVDFGGPYPRISMLNAIKQYNPDNAEIQALTYEQVADRELMANIARGLDIYVEKFWTCGQLLEEIFGETAEPQLMQPTFITEYPADISPLARRNDTNDFITDRFEFFIGGREVANGFSELNDAQDQDQRFKAQVNAKDAGDDEAMYYDADYITALEHGLPPTAGQGIGIDRLVMLFTNTHTIRDVILFPALRPQNKA
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCNF_XENLA
Sequence: MKGGGLHCRCSKCFAAPPRRRIKRRPRVLTLLSLPEDVLLYVLECLPAVDILSMREVHPHLRSLVDSHSSVWARASFQDVWPSSENLNLFERAAECGNFEACVKLGIAYLYNEGLSVSDDGRAEVNGLKASRFFSLTERLNAGADPFVWLFIRPPWSSSGSCCKAVVFDSLNEECGTVTSGEGATGALKGSIQYCLAKVLSLFEDDDKKREALGMLESSASNGCLHSAYLLWETKQKAALSDPGRYLQSFRQLRDYAARGCWDAQISLAKACGHKNPLNQEQRSAGELVNQVFQSSLPINKSSIFTTQKGMNDTMRYILIDWLVEVATMKDFSSLCLHMTVGLVDRYLKLRSVPRAKLQLVGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIISALEGKIRMPTVVDYKDVLSHLIPLDRNTLHLCSYISELSLLYTELSMYSPAQLAAGALLLARILHRQARPWPAQLAETTGFTLEHLTPCVVLLHKKCFHDDAPRDYRQVSLTAVKQRFQDDLYDQISKEKVMDHTHLCELLGVPCHDSESPATCPNAADFHQFLCSPSGNKTKRRREESIQEDRGSFVTTPTAELSNQEEDLLGDFLDWSLETSCSGYEGDRESEGEREGEVTAPSGVLDLSLLLTEHPQCQDSTTDDDSITLHPIPLLSKAENGTDSIEGCVEKSSGYSSVSSGGSPTSSSSPGLPFTPTPGLNHSKLTPIPFPQPCSPLLKASRRQVKRKNQAQHSEDNLSDEL
What is the function of this protein?
Substrate recognition component of the SCF(CCNF) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity).  Mediates the substrate recognition and the proteasomal degradation of various target proteins during G2 phase involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity).
What are the official names of this protein?
Cyclin-F.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localizes to the nucleus in G2 phase.
Protein: FADI_SERP5
Sequence: MSKALPLVTRHGDRIAIVNGLRTPFAKQATAYHGIPAVDLGKTAVSELLARTGIDPALIEQLVFGQVVQMPEAPNIAREIVLGTGMSVHTDAYSVSRACATSFQAIANVAESIMAGSISIGIAGGADSSSVLPIGVSKALARTLVDVNKARTLSQRLKLFSRLKFRDLMPVPPAVAEYSTGLRMGDTAEQMAKSHGITREEQDALAHRSHQLAAKAWEQGLLHDEVMTAYVPPYRTQISEDNNVRKDSSLASYAKLKPAFDRKHGSVTAANSTPLTDGAAAVLMMSESRAKELGLQPLGYLRSFAFSAIDVWEDMLLGPSYATPLALDRAGIGLADLTLIDMHEAFAAQTLANLKMFASDEFAQQKLGRSRAIGEVDMDKFNVLGGSIAYGHPFAATGARMITQTLHELKRRGGGLGLTTACAAGGLGAAMIVEVE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URK_STRZP
Sequence: MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYKDQSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQEPQDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQYLGVVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBXL8_BOVIN
Sequence: MAEPGEQLPEEVLALIFRHLPLPDRAAAARVCRAWAAAATCSAVWHDTSISCDCELEGMLPPYLSACLDHVQNLWLEFEPSRKSSRRAATDLLTALTGRTPGLRGLCLECRGEKPLFDAGRDVLDAVHALCGAASALRHLDLRRLPFSLDDALVLQVAHGCPELRSLFLDNRTLVGSVGPGSVLELLEACPCLRALGLHLASLSRTALEALAAPERAPFELLALRCACPEDARAPPLPDEAWAALSLRHPGLQVELELEPVLPAESVTRVLQPAVPVATLRLSLSGDTVGPVRFAARHYAATLRALEVRAAASAELDAALEELAARCARLREVHCFCVVRPSVLHAFRARCPRLRSYTLKVTREPHPWRPTLVA
What is the function of this protein?
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
What are the official names of this protein?
F-box/LRR-repeat protein 8, F-box and leucine-rich repeat protein 8.
Protein: TORD_VIBCH
Sequence: MMQELKILNEKRAEIYWWLSSLFFKELSEQDIARYHSAEVRTFLSGLADEQSLNREVKHLVEALNRLQNRQDAQLELAADFCDLFLKSDRDSALPYASVYTDKGLLNGKPAQQMRELLGAHGVKVEQNLNEPEDHLAIQLDFLAHLAISANQIEHSAQLSSALQAQSDFISQHLLTWLPAFAERCTQFDAFGLYSAAARLALAFIQQDKHCLDELFQETH
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG1_BDEBA
Sequence: MSEHFEKRRPVFLQLGFNEAALPQLKAYLDLLWSSNEELNLISRKMTYEELIDNHVIDCLLPIKDFPKDVKVAADFGSGGGLPGVIYAIQFPNVEYHLFEKSKLKQDFLNRCVSIAPNLRIHGEIPPKLEKIEVVTSRAFKPVDVILEFSRDYYKKGGKYFLLKGRKEKIDEEVALARKKFKDLKVTVQPLSSPVLEVERHLVLI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G 1, 16S rRNA 7-methylguanosine methyltransferase 1, 16S rRNA m7G methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYVE1_MOUSE
Sequence: MLQHTSLVLLLASIWTTRHPVQGADLVQDLSISTCRIMGVALVGRNKNPQMNFTEANEACKMLGLTLASRDQVESAQKSGFETCSYGWVGEQFSVIPRIFSNPRCGKNGKGVLIWNAPSSQKFKAYCHNSSDTWVNSCIPEIVTTFYPVLDTQTPATEFSVSSSAYLASSPDSTTPVSATTRAPPLTSMARKTKKICITEVYTEPITMATETEAFVASGAAFKNEAAGFGGVPTALLVLALLFFGAAAVLAVCYVKRYVKAFPFTTKNQQKEMIETKVVKEEKADDVNANEESKKTIKNPEEAKSPPKTTVRCLEAEV
What is the function of this protein?
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane.  Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS).  May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10187853).  Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (By similarity).
What are the official names of this protein?
Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1, Extracellular link domain-containing protein 1.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
Protein: CSI5_BACIU
Sequence: MRNIKVKPFLN
What are the official names of this protein?
Cold shock protein CSI5, 11 kDa cold shock protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THYX_HELPJ
Sequence: MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGCKDRDLIHRVGNIFRHSSTLEHLYYNFEIKGLSRGALQELSRHRIASLSVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVDDEKVNEMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLAYSINARSLQNLLTLRSSNKALKEMQDLAKALFDALPYEHQYLFEDCLKH
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: PGAM5_DROSE
Sequence: MRKLTSFACGTGAGLAAYYLQRLRDPQTAVQNSWTHSDKPVDPWALWDTNWDCREPRALVRPLRNSQPEEENRYNAELEKAKAKKARHIILVRHGEYLDVGDSDDTHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMMRAQETSDIILKQIDFEKEKVVNCAFLREGAPIPPQPPVGHWKPEASQFLRDGSRIEAGFRRYFHRAYPDQEKESYTLIVGHGNVIRYFVCRALQFPAEGWLRININHASITWLTISPSGNVSIKYLGDSGFMPAELLTNRIPRDVKNVV
What is the function of this protein?
Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase.  Has apparently no phosphoglycerate mutase activity (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase Pgam5, mitochondrial, Phosphoglycerate mutase family member 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: MRAY_GEMAT
Sequence: MLYFLLQPLARDVRLFNLLNYITFRAAAAFVTALLVSFILGPAIIRRLRAMAVHQVVREGTPDTHAGKGTTPTMGGLIILAATFAPVLLWSRLSNRYVLLAMAVTAWMGVIGFLDDYLKLKQKREGKKNEGLVERYKLAGQVLCGLGLGAYLLLSPISTLPGASTTLPFFKYVLVVPAVAWAAWLYIPWVTFILTGVSNAVNLTDGLDGLSSGLVAIAVLTLGLFAYVLGRVDTSAYLQVFYLRGAGELTVFCAAVVGACIGFLWYNAHPAQVFMGDTGSLALGGAVGAIAILLKSEFLLLFVGAVFFAETVSVILQRTVFKYRLRRYGREYAQKHRVFRRAPLHHHFEMMGWPETQVVVRFWIIGILCAILALSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VL1_HPV69
Sequence: MALRRTSDSKVYLPPTPVSRVVRRMNMYTHRIYYYAGSSRLLTLGHPYFPIPKSGSTAEIPKVSAYQYRVFRVHLPDPNKFGLPDPQLYNPETERLVWACVGVEVGRGQPLGVGLSGHPLFNKLDDTENSHLATANADTDNRDNVCVDNKQTQLCIIGCTPPLGEHWGVGTVCKNAQSQVQRGDCPPLELISSVIEDGDMIDTGFGAMDFTALQATKCDVPLDINQSICKYPDYLKMSADTYGNSMFFFLRREQLFARHFFNKAGTIGDSVPVSMYIKGAGQGREPPTTSIYSRTPSGSMVTSDAQLFNKPYWLQRAQGHNNGICWGNQLFVTCVDTTRSTNLTISTVSAQSASATFKPSDYKQFIRHGEEYELQFIFQLCKITLTTDVMAYIHTMNSTILENWNFGLTLPPTASLEDAYRFIKNSATTCQRDAPAQPKEDPFSKLKFWDVDLKEKFSIDLDQFPLGRKFMLQAGIQRRPKLGTKRPASSLSASSSSTTRKKRKLTK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: HEM3_HELPH
Sequence: MGNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGEIDLAVHSLKDVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGEFDAIILAEAGLCRLEIQGAKYRKAFSVKEMIPSMGQGALGVEMLKNHKHFITLQKLNDEKSAFCCRLEREFIKGLNGGCQIPIGVHASLMGDRVKIQAVLGLPNGKEVIAKEKQGDKTKAFDLVQELLEEFLQSGAKEILEKAQLF
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RCNR_CITK8
Sequence: MSHTIRDKQKLKARASKIQGQVVALKKMLDEPHECAAVLQQIAAIRGAVNGLMREVIKGHLTEHIVHQSDEVKREDDLEVILKVLDSYIK
What is the function of this protein?
Repressor of rcnA expression.  Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt.  In the presence of one of these metals, it has a weaker affinity for rcnA promoter (By similarity).
What are the official names of this protein?
Transcriptional repressor RcnR.
What is the protein family that this protein belongs to?
Belongs to the FrmR/RcnR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WSB1_DANRE
Sequence: MASFPDCVNENEIGKAKFIGELIPPVAPFDQKSGRETWTVAFAPDGSYFAWSQGHRIVRLVPWKKCLASFSVRKEDRSSGAGPRRLSRQNSEGSLLPGEPREHTIDCGDIVWGLAFGSSVPEKQSRCVNIEWHRFKFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLMDHTDIVRDLTFAPDGSLVLVSASRDKTLRVWDLKDDGNMVKVLRGHQNWVYCSAFSPDSSVLCSVGAGKAVFLWDMDKYTLIRKLEGHHNDVVCCEFSPDGALLATASYDTRVIVWDPHTATVLLELGHLFPPPSPIFAGGANDRWVRSVAFCHDGRHIASVTDDRLVRFWSIDEKSPQAIGPLTNGLCCAFSTDGSVLSAGSRDGSVHFWASPRSIASLQHLCRMTLRRVMPTQQVYTLPIPFSMQDYLAYKTL
What is the function of this protein?
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
WD repeat and SOCS box-containing protein 1, WSB-1.
Protein: H2A_CHITH
Sequence: MSGRGKGGKVKAKAKSRSSRAGLQFPVGRIHRLLRKGNYGERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTESKKA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.