PharMolix/UniProtQA huggingface dataset:
Protein: SYL_PROM3
Sequence: MTESFPSTSASSHSSARYDPIELETRWQKEWLRQGLDRTPVAETNQKRFYALSMFPYPSGKLHMGHVRNYVITDVIARVQRMRGDAVLHPMGWDAFGLPAENAAIARNVDPGDWTDQNIAQMRAQLDRLGLSIDWDRQQATCHQDYYRWTQWLFLELFAGGLAYQKEATVNWDPIDKTVLANEQVDGEGRSWRSGALVEQRQLKQWFLRITDYADALIDDLDELTGWPERVRTMQANWIGRSHGAEIKFRVAGQTNSIITVFTTRPDTLHGASYVVLAPEHPLVEALTSPQQRIAVTAFCDLISQLSVKDRTAEDQPKRGVPIGAQVINPVNGESLPVWIADYVLADYGSGAVMGVPAHDERDFIFARSHELPIRIVVQMPDSDEHHNDGQAWTGAGVLVNSGAFDGLSTEEGKVAITTHGASKGWAQSKVQYRLRDWLISRQRYWGCPIPIIHCASCGIVPVPQEDLPVTLPRDIDLSGKGGSPLAQEQDWVEVKCPICGEKAHRETDTMDTFMCSSWYYLRFADPLNSQRPFDKDIVDEWLPVDQYVGGIEHAILHLLYARFFTKALHDRNLIGFKEPFNTLLTQGMVQGLTYRNTKNGSYISPELVSDEGDPRDPESGDKLEILFEKMSKSKYNGVDPAVVIDRYGADTARMFILFKAPPEKDLEWDDADVEGQFRFLQRLIRLIDSFVWPKTDEDNASISSANLTISSADLSEEEINMRRATHMAIEAITEDLSGDIQLNTAISELMKLSNSLGGKLDKVRTEVAAEALSVLVRLMAPFAPHLAEEFWMKLHGQGSIHQQSWPIIDPSALVLETIELVIQVKGKVRGTIQVPANADKTALEELALKSDIAVKWLEGQSPRRVIIVPGKLVNLVP
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPAR2_MOUSE
Sequence: MGQCYYNETIGFFYNNSGKELSLHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGMAYLFLMFHTGPRTARLSIKGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVTLIVGVWAAALGLGLLPAHFWHCLCDLDSCSRMVPLFSRSYLAAWALSSLLVFLLMVAVYTRIFFYVRRRVERMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLDCKSCNVLAVEKYFLLLAEANSLVNAVVYSCRDAEMRRTFRRLLCCMCLRWSSHKSARYSASAQTGASTRIMLPENGRPLMDSTL
What is the function of this protein?
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.  Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins.  Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity).
What are the official names of this protein?
Lysophosphatidic acid receptor 2, LPA receptor 2, LPA-2, Lysophosphatidic acid receptor Edg-4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
Protein: FLAV_NOSSM
Sequence: SKKIGLFYGTZTGKTESVAEIIDEFGDEVVTLDID
What is the function of this protein?
Low-potential electron donor to a number of redox enzymes.
What are the official names of this protein?
Flavodoxin.
What is the protein family that this protein belongs to?
Belongs to the flavodoxin family.
Protein: GPPA_ECOHS
Sequence: MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQESQWQSYVHWPLEVH
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: CH60_PHOPR
Sequence: MAAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFQNMGAQMVKEVASQANDAAGDGTTTATVLAQSIIAEGLKAVAAGMNPMDLKRGIDKAVIAAVAALKELSVPCEDTKAIAQVGTISANADATVGNLIAEAMEKVGRDGVITVEEGQALHDELDVVEGMQFDRGYLSPYFINNQEAGSIDLESPFILLVDKKVSNIRELLPALEGVAKASRPLLIIAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKSMLQDIAVLTAGTVISEEIGLELEKVQLEDLGQAKRITITKENTTIIDGAGEETMIQGRVAQIRQQIEDATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVQDALHATRAAVEEGVVAGGGVALIRAASKVAASGLEGDNEEQNVGIRVALRAMESPLRQIVKNAGDEDSVVANNVRAGEGNYGYNAATGVYGDMIAMGILDPTKVTRSALQFAASVAGLMITTEAMITDMPAKDASAMPDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECOT_ECODH
Sequence: MKTILPAVLFAAFATTSAWAAESVQPLEKIAPYPQAEKGMKRQVIQLTPQEDESTLKVELLIGQTLEVDCNLHRLGGKLENKTLEGWGYDYYVFDKVSSPVSTMMACPDGKKEKKFVTAYLGDAGMLRYNSKLPIVVYTPDNVDVKYRVWKAEEKIDNAVVR
What is the function of this protein?
General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
What are the official names of this protein?
Ecotin.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SYH_STRA3
Sequence: MKLQKPKGTQDILPGESAKWQYVENVIRNLFKQYHYDEIRTPMFEHYEVISRSVGDTTDIVTKEMYDFHDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQKPTKMYYIGSMFRYERPQAGRLREFHQVGVECFGSNNPATDVETIAMGHHLFEDLGIKNVKLHLNSLGNPESRQAYRQALIDYLTPIREQLSKDSQRRLNENPLRVLDSKEPEDKLAVENAPSILDYLDESSQAHFDAVCHMLDALNIPYIIDTNMVRGLDYYNHTIFEFITEIEDNELTICAGGRYDGLVSYFGGPETPAFGFGLGLERLLLILDKQGISLPIENTIDLYIAVLGSEANLAALDLAQSIRHQGFKVERDYLGRKIKAQFKSADTFNAKVIMTLGSSEVDSKEVGLKNNQTRQEVKVSFENIKTDFSSVLKQLGL
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_SHEFN
Sequence: MAKEDNIEMQGTILETLPNTMFRVELENGHVVIAHISGKMRKNYIRILTGDKVTVQLTPYDLSKGRIVFRAR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_SULIN
Sequence: MLIIIRPSGEIALKSPRSRRNFEHTLANNIRSVIKEGKIWRSQGVLFLEVNDNNKNIEELSKVFGIASFSPVMSIKSYNNNLEDIINKAKEVFAEIVKGKIFSVRAKRIGSHNFTSLDVQRKVGEALYPFSRGVNLENPEVEVFIEIRNDVAYFYYKIIKGPRGLPVGVAGKTVVLFSGGIDSPVATWMMMKRGSIPVILNFNLGGSVHRKFVLEELSVLRKWSGGHKLKLFIVNGTDVLIKLSQIEKRNRVVMLKRVMYKVAERLCDKANAKSITTGESLSQVSSQTMTNLYVTEYGIKYPIFRPLIGFDKEEIVELARKIGTYEYSIKLPEYCAISTKARTSVELDEVLKDEENLNIDYEKVLENSEVIEI
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_FLAPJ
Sequence: MNHYETVFILNPVLSETQVKETVSKFEDYLTSKGATMVSKEDWGLKKMAYEIQNKKSGFYHLFEFTVPGEVLIGFETEFRRDERVMRFLTVSLDKHAISWAERRRAKLKATKA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: NAC_METJA
Sequence: MFPGKVNPRMLKKMQKMMKDFGMETEDLDVRKVIFVFDDEEWVFEEPKVQVMDILGVKTYSITGKPKKIKKEKVEEEEEVKVEITEEDVELVAKQCNVSKEEARKALEECNGDIAEAILKLEEEKEEN
What is the function of this protein?
Contacts the emerging nascent chain on the ribosome.
What are the official names of this protein?
Nascent polypeptide-associated complex protein.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: DXR_YERPA
Sequence: MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEHSAKSLRLLLAEQGSDTEVYSGETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQVLLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSLPERIQRQLGYSSLNENGVSRIILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFCKVGALTFTTPDYQRYPCLKLAIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVINRTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: YPC1_ECOLX
Sequence: MDKLLNKKIKVKQSNELTEAAYYLSLKAKRVLWLCLMQTYFTASVSEDDDEMAVLGDSTFKVKVADYQQIFQVSRNQAIKDVKEGVFELSRSAVIFYPKEGSFDCVARPWLTEAGSRSARGIWEIEFNHKLLRYIYGLTNQFTTYSLRDCGSLRNPRTIRLYESLAQFKSSGLWVTTHAWLNDRFLLPESQQKNLAELKRSFLDPALKQINEKTPLLAKYSIDDSGKFLFSIIDKQNPV
What is the function of this protein?
Mutations in ORF 239 affects the incN plasmid pUC1 E. coli polA-independence but not its autonomous replication ability.
What are the official names of this protein?
Uncharacterized 27.6 kDa protein, ORF 239.
What is the protein family that this protein belongs to?
Belongs to the initiator RepB protein family.
Protein: ACYP_SHIBS
Sequence: MSKICIIAWIYGRVQGVGFRYTTQYEAKRLGLTGYAKNLDDGSVEVVACGEEGQVEKLMQWLKSGGPRSARVERVLSEPHHPSGELTDFRIR
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: MET_NEONE
Sequence: MKAPAVLAPGILVLLFTLVQKSYGECREALVKSEMNVNMKYQLPNFTAETPIQNVVLHKHHIYLGAVNYIYVLNDKDLQKVAEYKTGPVLEHPDCFPCQDCSHKANLSGGVWKDNINMALLIDTYYDDQLISCGSVHRGTCQRHVLPPSNTADILSKVHCMYSPQADEESSHCPDCVVSALGTKVLISEKGRFINFFVGNTINSSYLTDHSLHSISVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKYIHAFESNRFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGAHLAKQIGANLNDDILYGVFAQSKPDSAEPMNRSAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRSDEYRTEFTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGSSTPHVNFRLDSHPVSSEAIVEHPLNQNGYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPPFVQCGWCHDKCVQLEECPSGTWTQEICLPTIYEVFPTSAPLEGGTMLTVCGWDFGFRRNNKFDLKKTRVFLGNESCTLTLSESTTNMLKCTVGPAVNEHFNISIIISNGRGTAQYSTFSYVDPVITSIFPSYGPKTGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQTIPTEFPIKLKIDLANREMNSFSYQEDPIVYAIHPTKSFISGGSTITAVGKNLNSVSVLRMVISVHETRRNFTVACHHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGIHSKYFDLIYVHNPVFKPFEKPVMISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCETIYSDSEAVLCKVPNDLLKLNNELNIEWKQAVSSTILGKVIVQPDQNFTGLIVGVISISIILLLLLGVFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDLSPMLNSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDSDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAELRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNIDGEGDT
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.  Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.  Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.  Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.  During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation.  In adults, participates in wound healing as well as organ regeneration and tissue remodeling.  Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
What are the official names of this protein?
Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: APOA1_PANTR
Sequence: MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ
What is the function of this protein?
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).  As part of the SPAP complex, activates spermatozoa motility (By similarity).
What are the official names of this protein?
Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: SFGH1_ECOL5
Sequence: MELIEKHASFGGWQNVYRHYSQSLKCEMNVGVYLPPKAENEKLPVLYWLSGLTCNEQNFITKSGMQRYAAEHNIIVVAPDTSPRGSHVADADRYDLGQGAGFYLNATQAPWNEHYKMYDYIRNELPNLVMHHFPATARKSISGHSMGGLGALVLALRNPDEYASVSAFSPIVSPSQVPWGQQAFAAYLGENKDAWLDYDPVSLISQGQRVAEIMVDQGLSDDFYAEQLRTPNLEKICQEMNIKTLIRYHEGYDHSYYFVSSFIGEHIAYHANKLNMR
What is the function of this protein?
Serine hydrolase involved in the detoxification of formaldehyde.  Hydrolyzes S-formylglutathione to glutathione and formate (By similarity).
What are the official names of this protein?
S-formylglutathione hydrolase FrmB, FGH.
What is the protein family that this protein belongs to?
Belongs to the esterase D family.
Protein: DNAJ_PARDP
Sequence: MAKRDYYEVLGVARGASADEIKKAYRAKAKQLHPDRNKDCKVSEAAFKEVNEAYECLKDDQKKAAYDRFGHAAFENGGGGFGRGNGHGDFGSAFADVFEDLFGDMMGRRAGGGGRSRASRGQDLRYNLRVSLEEAYNGAQKTINVPGSVACAACNGTGAEGAVEPATCPTCSGMGKVRATQGFFTVERTCPTCSGHGQIVKNPCQECRGAGRVQKERTLSVNIPAGVETGTRIRLAGEGDAGMRGGPAGDLYIFIEVREHPIFMRDGRMLACQVPVSMTTAALGGEIEVPTIDGGRSRVKVPPGTQSGKQLRLRGKGMPPLRHGPGLNGEAGDMLIELAVETPVNLTARQKELLREFEAINADNNPQTQGFFQKIKGFWDEMKG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMEK_DICDI
Sequence: MEPLRKRVKVYQLDNSGKWDDKGTGHVSCIYVDALCAMGLIVRSESDNSVILQTRLSAEDIYQKQQDSLIVWTEPDSQLDLALSFQDSLGCQDIWENILQYQNQRTGSCDSVDLDLPPVSINNLQTINELLEASLPMLDKDKIINSIFKEDLVRSLLDLFDEIEKSGEGGVHLFQIFNIFKNLILFNDTSILEVILSEDYLVRVMGALEYDPEISENNRIKHREFLNQQVVFKQVIKFPSKSLIGTIHQTFRIQYLKDVVLPRVLDDVTFSSLNSLIYFNNIDIVSQIQNDSDFLENLFSEIQKSEKNSEERKDLILFLQDLCNLAKGLQIQSKSTFFTVVVSLGLFKTLSAILDDENVQTRVSCTEIVLSTLLHDPEILRSYLCSPTSGNSKFLVQLINLFITDKDIGVKNQIVEIIKTLLEADSYDSSDFFRLFYDKGIDLLVSPLNEVYKGEPTIPGDPSSNLDSFVLYNIMELVIYCIKHHCYRIKHFIVEEGIAKKILRYTNPTGSGGGGGGGGNSERYLILGSIRFFRSMVNMKDDLYNQHIIQENLFEPIIEVFKSNISRYNLLNSAIIELFQYIYKENIRDLIVYLVERYRELFESVTYTDVLKQLILKYEQIKDSSFESPETSCNNNDSSSNDIDSKPIIGNNKINHNYQRTQREIDEEEEEAYFNRDDDSEDSDDEDELIPISINNNNNNNNNNKQICTNNENNMEKNDDNIEKDNENTNNGNGSSHIKIVDYEDEDDEDDEINKSVESDDIVEKHEIIDKNEKKDEIMKENNDSDNDDNDNNDNDNDNDNNSDIENKNHLNNNGNNENNENNDDVQDKSNNKNNSDKINEDEKIEKQDEMKENLEMEEIDEKVKEKQPKDIKKENQSQPDETVFNGKSNNSNNNNNNNNNNSNNQEIGDNRKTTPKRKLDYEKNESVVSKKIDKSNGPTSIDKDINGCDESPNKKLNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNQNDENELSSASEEEEEQLENGKHIKKFKRGKKDSNNSSNNSNNSSPTPSELHV
What is the function of this protein?
Suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects.  Required for proper cytokinesis during vegetative growth, timely exit from the mound stage during development, and myosin II assembly.  May be a regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) and may control localization of PP4 to the nucleus.  Involved in the regulation of some ppp4c functions, such as developmental progression, chemotaxis, expression of stress response genes and cell movement.
What are the official names of this protein?
Suppressor of Mek1, SMEK.
What is the protein family that this protein belongs to?
Belongs to the SMEK family.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Nucleus. Note=Localizes to the cell cortex in vegetative cells but translocates to the nucleus during starvation and development (PubMed:16107728).
Protein: PMP1_SCHPO
Sequence: MSQKLPPLKIYTSQLPLVSHKNMLENEEEASHSQLFTPCPVPPSFPKASKPNSNQPYPNGPVCIYPPNIYLYAKPTMPIIQSFDVVINVAKEVLHPFRTDGRHYRDSKHNLDIQVFDHIEYVHIHWDHDTQFALELDKLVSFVAYNAMQLNKKVLINCQMGISRSACLMIAFIMKTLNLNVSDAYEYVKERSPWIGPNMSLIFQLSEYQQIIRKNSSQGPYQSSSLKQSKRKSEGNLLFPEKPHSAQLPLVSPSTSESSMFTNLRRTRSSGSISNDAS
What is the function of this protein?
Dual specificity phosphatase that dephosphorylates MAP kinase pmk1 on a Tyr.  Has a role in chloride ion homeostasis by inactivating this pmk1 MAP kinase pathway.
What are the official names of this protein?
Tyrosine-protein phosphatase pmp1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Protein: IF3M_MOUSE
Sequence: MAVLLMRLMLQTTKLDHNLIGRCLQRHAVKPDPAQLSLSASTPKLLYLTSAKGFSTAGDPQGERKQKRRDAFSNTGRKISERIIRVLDEKGMDLGMMHRADVIRLMNKQDLRLVQRNTSSEPPEYQLMTGEQIHQERLKLREQEKAKPKTGPTMTKELVFSSNIGQHDLDTKSKQIQQWIEKKYHVQVTIKRRKDAEQSEEETEEIFNQILQTMPDIATFSSRPKAIRGGTASMCVFRHLSKKEEKAYRESQESQRRDTLSKDDDGNSKESDVVCQ
What is the function of this protein?
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3, mitochondrial, IF-3(Mt), IF-3Mt, IF3(mt), IF3mt.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MUTS_LEPIC
Sequence: MNLESTATSAEYWSDLADALNTPMMKQFLAIKKDFPDTILFFRMGDFYEMFLEDAKIASSILDIALTKRQNAVPMCGIPYHSKDNYISRLLNAGKKIAICEQSKPEEAGSKLMTRDVVRIITPGTVIEENLLSGFQNNYLAVLHLKKSLIYFAIADFSTGEVFYSSVSVTGLERLIAELEKFKPSEICVPKSEHTFFQELEYFKNREFTVLKNQIETSEKDSFQVLSKYLNEYIRETYRDNKLVLREPKILSSGKFLEMDRETIRNLELVENEKEKNNTLYSIFNFCNTAKGKRLLKQRILFPECDPVVLYSRWEKQDILLKTVLAPYITALKDFGDLERILTRFRGNHAYPRDFRSLLNSISSGIKLKEELEKVSYPFLIPIEELKKISDFIQERLHPGDDLPVILGNGIFLKKGFSQKLDQAREAGVKGKDWILDLETKEKKRTGLNTLKIRYNKIVGYFIEISRAQAEQAPKDYLKKQTLVGSERFTMPKLEEIERTILEADEIIQEIERTEFNRMVEEVLKFSSSLLSFSEEIGDLDFQISLLTAKDKFGWIRPKLSEDRSLDLNDSRHPVVEATLPPGQEFIPNSVYLDTQDKAIAVLTGPNMAGKSTFMRQIALNQILFQIGAFVPAKSAKLPIVDKLFTRIGAGDNLTAGESTFFVEMKETANILNHYTEDSLILFDEVGRGTSTYDGMSIAWSILEYLSSLSVRPKTIFATHYHELTELSRLGGIFNLYLETLEKEDRVLFLRKVKVGKAKKSFGIYVAKIAGVPEPIVKRAAELLTDLESKKKEIKIQEAQPTLFTEPETKNFNSQTEESILKLKLEEMTPIEALKTLEDFQKKLRKQK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RGLT_ASPFU
Sequence: MQFDSLPLPPSSSHDTTSVPPLKRHAACDECRKRKLKCSGEATGCSRCLKQSLPCHYSLQKPMGRPPKKRPREDNDASVYEITDNGMWADIDDGGILTEEAGAEATAASDALRLCPPVYTAPMRMPQAFPNLLSTDDSHNHLWQLESGRSLDPIPATTGPWPDFSSVTAATSSPFTLPSSLTLIDSPSVSSPSSDGGNSSQCTCLSYLYLCLSHLSSLAPFPISQHTLCSLFIAAKTARAVIRCEVCPTSFALGMQNVMFTGTLLNVIADAWLRVSQADAEELGKLAAPPAYVASVTQNSPNPAEAWKDWLRQTVRSAITGGPADPAGQVKCSDSPTLLSLIEEMEARQHRWHRTRTVESPNEPGSCSPVSHEDHREEDMLCFRVIRSARDVIAKFEFAPHEYPEGVVPV
What is the function of this protein?
Transcription factor that is involved in protection against oxidative stress (PubMed:32667960).  Binds to promoter regions of the gliotoxin (GT) biosynthetic genes gliZ, gliF, gliT, gliM, gliA and gtmA (PubMed:32667960).  Two related but different DNA motifs (5'-TCGG-3' and 5'-CGGNCGG-3') are specifically enriched among rglT binding sites in GT-inducing conditions (PubMed:32667960).  Also indirectly regulates the expression of gliP, gliG, gliH and gliN (PubMed:32667960).  Plays a key role in resistance against exogenously-added GT and GT biosynthesis, mainly through the direct regulation of gliT (PubMed:32667960).  Furthermore, rglT is important for virulence in chemotherapeutic mice with invasive pulmonary aspergillosis (IPA) (PubMed:32667960).
What are the official names of this protein?
Transcription factor rglT, Regulator of gliotoxin.
What are the subcellular locations of this protein?
Nucleus.
Protein: C513F_DICDI
Sequence: MILSLLFLFVITLYFLIPSRISKINKNIPGPIGYPIVGNLFQINKNVVKSIDGFYKEFGPVYRLRMGNIETVVLTGIDTLEESFLFNKHSFVDRFVKKSRKINNGLDIIHSNGEYWKILKTIFQTQMTPRKIKSYQFEIQSQVDLMAEQLYKSKNNDNIVTNINENMKFMLFNIMSILIFGKQSIYCNNTNNINNKDDDDVDKEKKHIIFSIGRFFKTSGSLFYSDFIPILLPFDLINLSRNNFFKDFQVLTNFVSKNVNQQLSKLNDNNNNNKEKEGEERKSIVEAYLENYLNGEIKFESVLSSCTNLLLAGTDSSANTLSFLLVSLINNPEIQEKVYNEIITNLKNDEISINDRFKCPYTCAVIKETHRLYSIAPLSEPHYCSNDVEIKGFKIAKGTQIIQNIYSSSRSEQYWDKPLSFIPERFIDNANIKEKNKNIVSFGLGLRGCIGKSFAEYMIFLTVVRLIKNYKFSNPSPNQPLKEIGEYGLVMNCANYNAKIEKRK
What are the official names of this protein?
Probable cytochrome P450 513F1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.