PharMolix/UniProtQA huggingface dataset:
Protein: K22E_RAT
Sequence: MSCQISCKSRRGGGGGGGGGFRGFSSGSAVVSGGSRRSTSGFSCLSRHGGGRGGSGGGGFGSQSLVGLGGYKSISSSVAGYGGGFGGRSYGGFGGGSGFGGSGGFGGGSGFGGGRGFGGGSGFGGGSGFGGGSGFGGGSGFGGGGFGGGRFGGGPGGFGGPGGFPGGGIHEVSVNQSLLQPLDVKVDPEIQNVKSQEREQIKTLNNKFASFIDTVRFLEQQNQVLHTKWELLQQLDVGTRTTNLDPVFQAYIGILKKQVDRLTAERNSQDSELNNMQDLVEDFKKKYEDEINKRTSAENDFVTIKKDVDSCYMDKTELQAKMEMLTQEVDFLRTLYDTELSQLQQNVTDTNVILSMDNNRNLDLDSIIAEVQSQYEIIAHKSKAESEELYHSKANEELQVTAVKHGDSLKEIKMEISELNRTIQRLQGEISHVKKQCKGVQDSIADAEQRGEHAIKDARGKLTDLEEALQQGRENLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDFSDNVSVSVTSSTISSSVASKAGFGSGGQSSGGRGSYGGRGGGSTYGSGGRSSGVRGSGSGSGGGGYSSGGGSRGGSGGGGYSTGGGSRGGSSSGGGGYSSGGGSRGDSSSGGGSRGGSGGGSRGGSGGGGYSSGGGSRGGSSSGGAVSGSERGGSGSGEGCGSGVTFSFR
What is the function of this protein?
Probably contributes to terminal cornification.  Associated with keratinocyte activation, proliferation and keratinization (By similarity).  Required for maintenance of corneocytes and keratin filaments in suprabasal keratinocytes in the epidermis of the ear, potentially via moderation of expression and localization of keratins and their partner proteins (By similarity).  Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).
What are the official names of this protein?
Keratin, type II cytoskeletal 2 epidermal, Cytokeratin-2e, CK-2e, Epithelial keratin-2e, Keratin-2 epidermis, Keratin-2e, K2e, Type-II keratin Kb2.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSCA_ACTP7
Sequence: MALLQIAEPGQTAAPHQHRLAVGIDLGTTNSLVASVRSGQTQVLLDDQERALVPSVVHYGEQQKTVGIEAFTQASLDPQNTVISAKRLIGRSLADVQTRYPDLPYQFIASDNGLPLIQTKQGNKSPVEVSADILSHLNRFAEQRLGGELSGVVITVPAYFDDAQRQSTKDAARLAGLNVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDTALGGDDFDHLLADWIAQQANYKPQNANEQRELLTLATQTKVALSQAVETEVKFANWQGTVSREQFNELIQPLVKRSLMTCRRALKDAGVEGEEIREVVMVGGSTRVPFVREQVGEFFGKQPLTSIDPDKVVALGAAIQADILVGNKPDSEMLLLDVVPLSLGIETMGGLVEKIIPRNTTIPVARAQEFTTAKDGQTAMSVHVLQGERELVEDCRSLGRFTLRGIPPMVAGAATIRVTYQVDADGLLSVTAMEKSTKVQASIQIKPSYGLTDEEVTQMIKSSMTNAKEDMEARQLAEQRVEADRTIDTVISALQQDGAEVLSVEEFKLIEAEIAKLIQLKQGTDRQAIAQGVKDLDLATQTFAAKRMNLSIQKALAGKAVDEII
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PYRH_SACD2
Sequence: MPNTPDRKYKRILLKLSGEQLMGDEGFGIDPKVLDKMALEIGQLVGIGVQVGLVIGGGNLFRGAALSRAGLDRVTGDHMGMLATVMNALAMRDALERSNISSTVMSAIPMHGVTDQYDRRKALRLLDNGEVVIFSAGTGNPFFTTDSAACLRGIEVNAELVLKATKVDGVYSADPMKDPTAVRYSKLTYEKVLTEQLGVMDLTAICLCQDHNMPVRVFQMDKQGALLNIVVGGDEGTLIQGKETEEA
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7L_LISIN
Sequence: MEQDKYLTVAAITKYIEKKFEVDPYMKQVFVRGEISNLKQPASGHLYFTVKDEFAMLRSVMFQKAVQKIGFVPEDGMNVLITGRIGVFTKAGRYQFYAEHMEPDGVGALYIQLEQLKSQLEKEGLFAEAHKKVLPSFPSKVAVVTSKTGAAVRDILTTIHRRMPSVEVIVYPTVVQGDKAAQRIVENIGRINQRNDIDVMIIGRGGGSLEELWAFNEEPVVRAVYDSDVPVISAVGHETDFALSDFSADVRAATPTAAAELAVPDYRDLEERLAERKYRLLAVTRQLLERKERALEQLKQHLILNGPKHQLEQQMERTDYFAERLKNAFSKQVLLKQTTFNRLNDRLHYYHPKKEIALQKEQIILRKQALDKAMKQQLKDKQQAFIRQVEALEHLSPLALLKRGFGVTYKAGELVKTVQELEIGDNIQVKMQGGHIDAHITAKEEDTSGN
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EAS_DROME
Sequence: MGTETKSNSYTGQISTSGGNPKVMKDSLSLVRQTVNQQTLSLSQSNQVQNQLNSHSNSNSYPNPSGSENKNENEQNSRDIRAKPEDKSRKEAIVPFVPIFVEEADVIQGAKELLKVIRPTWDLSHVEFKIRVVPQIEDRYPAQNAMVMMTLYSFTDGITNKLVGCFHKEISKLNDENGGSYLPIKTQGLSPVQSEDPVIIEKEDDDEFTDDRAADDGSPVQYSDNVVLVRIYGNKTDLLIDRKAETQNFLLLHTYGLAPSLYATFKNGLVYEYVPGTTLNTDSVLCPEIWPLVARRMAEMHRKVRKHGDSSATKPMPMIWKKTQSFLDLVPERFSDAEKHKRVKETFLPIGRLREEFNKLYEYLEALDSPIVFSHNDLLLGNVIYTQSLNTVNFIDYEYADYNFQAFDIGNHFAEMCGVDEVDYSRYPKREFQLQWLRVYLEEYLQRSNIQNDEVELLYVQVNQFALASHIFWTVWSLLQAEHSTIDFDYVGYAFLRYNEYLARKVEFLSLTAAKNNK
What is the function of this protein?
Highly specific for ethanolamine phosphorylation.  May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
What are the official names of this protein?
Ethanolamine kinase, EK, Protein easily shocked.
What is the protein family that this protein belongs to?
Belongs to the choline/ethanolamine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM183_PONAB
Sequence: MARGPGPLGRPRPDTVAMPKRGKRLKFRAHDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPTEEALSGAGEPCDIIDSSDEMEAQEESIHERTVSRKKKSKRHKEELDGAGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCTGGLQPPVQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQDSPVHGGRKPRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRALLLPIPWGQPRV
What are the official names of this protein?
Transmembrane protein 183.
What is the protein family that this protein belongs to?
Belongs to the TMEM183 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS2_AZOVD
Sequence: MSQVTMRDMLKAGCHFGHQTRYWNPKMGRYIFGARNKIHIINLEKTLPMFNEALSFVEKLAAGKNKILFVGTKRSAGRLVREEAARCSMPYVDHRWLGGMLTNYKTIRASIKRLRELETQSQDGTFAKLTKKEALMRTRDLEKLERSLGGIKDMGGLPDAMFVIDVDHERIAISEANKLGIPVIGVVDTNSSPEGVDYIIPGNDDAIRAVQLYLGSVADAVLRGRQNAGTGDEFIEEVAASEAAEG
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: MTNA_BOVIN
Sequence: MTLEAIRYSRGSLQILDQLLLPQQSRYEAVGSVRQAWEAIRAMKVRGAPAIALVGCLSLAVELQAGAGGPGLAALVAFVQDALSFLVTARPTAVNMARAARDLADLAAQEAEREGATEEAVRERVICWAEDMLDKDLRDNRSIGDLGAHHLLKRAAPQGGKVTVLTHCNTGALATAGYGTALGVIRSLHNLGRLEHAFCTETRPYNQGARLTAFELVYEQIPATLIADSMAAAAMAHQGVSAVVVGADRVVANGDTANKVGTYQLAIAAKHHGIPFYVAAPSSSCDLRLETGREIVIEERPDQELTDVNGVRIAAPGIGVWNPAFDVTPHDLITGGIITELGVFAPEELQAALSATIS
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NOC_BACCQ
Sequence: MKNTFSRLFGFGDKESEFELQDESHEEIDKKVYEEIQEIPIVNITPNRYQPRTVFDDARIEELALTIRTHGLIQPIVVRQYEDEKYEIIAGERRFRAATKLGWEKVPAIIKNLNDTETASVALIENLQREELTAIEEAVAYQKLIELHNLTQEALAQRLGKGQSTIANKLRLLKLPEEIKNALLEKSITERHARALIPLKNEELQLKVLQEIVEKQLNVKQTEERIAKLLEEAKPKRKAKQKAVSRDTRIAMNTIRQSLQMVADSGLNVNSEEEEFDEYYQITIQIPKKK
What is the function of this protein?
Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle.  It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage.
What are the official names of this protein?
Nucleoid occlusion protein, Noc.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SEPF_LACPL
Sequence: MAGFISNFFGVGDSDSQYEEPTEASQAAAPTESATNTRSTPKVVPMQGGKSVNSKIALFEPKIYSDVKEIATQLLKNQAVIINFDHVDDEMARRIVDFLTGTVFAINGEIERIGDEIFLCIPENYEVSGSTTSQFDTSKL
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: YR526_MIMIV
Sequence: MTDYQSKYSLYKRKYLSLKQKQNGGNNTADNTADNIDPIVKKFVDSIKDAKPVYEVTPEEARKNLNSIQSDQSYKTTVDMENVVVNDKNVNATIIRPKGNRDRLPVVFYVHGAGWVMGGLQTHGRFVSEIVNKANVTVIFVNYSLAPEKKFPTQIVECYDALVYFYSNAQRYNLDFNNIIVVGDSVGGNMATVLAMLTREKTGPRFKYQILLYPVISAAMNTQSYQTFENGPWLSKKSMEWFYEQYTEPNQNLMIPSISPINATDRSIQYLPPTLLVVDENDVLRDEGEAYAHRLSNLGVPTKSVRVLGTIHDFMLLNPLVKSPATKLTLEIVVNEIKRITTPNKN
What are the official names of this protein?
Putative alpha/beta hydrolase R526.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase 3 family.
What are the subcellular locations of this protein?
Virion.
Protein: CODY_LISIN
Sequence: MTLLEKTRKINAMLQNAAGKTVNFKEMADTLTDVIEANTYIVSRKGKLLGYSEALPIENDRMKQMLTERQFPEEYTQSLFNVGETSSNLEVSSQYTAFPIENSDLFTKGLTTIVPIVGGGERLGTLILSRLESNFTDDDLLLAEYGGTVVGMEILHEKAEEIEEEARSRAVVQMAISSLSYSELEAIEHIFDELNGKEGLLVASKIADRVGITRSVIVNALRKLESAGVIDSRSLGMKGTFIRVLNDKFLVELEKLKNN
What is the function of this protein?
DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability.  During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 36012_ASFM2
Sequence: MLPSLQSLTKKVLAGQCLPTDQYYLLKCYDLWWYDSPITFDHNLGLIKSAGIKDGLDLNTALVKAVRENNYNLIKLFTEWGADINYGLVSVNTEHTRDLCRELGAKETLNEEEILRIFIDLKFYKTSSNIILCHEVFSNNPLLQKVNNLKMRIEIFWELRELIKKTDLLNNEFSLNTLLLKYWYAIAVRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKIYMDLEEMMRVACIKDHNLSTIYYCYVLGANINQAMLASIQYYNIENMFFCMDLGADVFEENMPVGEGYELIRNILSLKIYSPSTAPLPKNTDPEIIDHVLKNYKSKNMMTFLSYDLR
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-12L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: LGMN_BOVIN
Sequence: MIWEFTVLLSLVLGTGAVPLEDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIVHRNGIPDEQIIVMMYDDIANSEDNPTPGIVINRPNGSDVYQGVLKDYTGEDVTPKNFLAVLRGDAEAVKGVGSGKVLKSGPRDHVFVYFTDHGATGILVFPNEDLHVKDLNETIRYMYEHKMYQKMVFYIEACESGSMMNHLPPDINVYATTAANPRESSYACYYDEQRSTFLGDWYSVNWMEDSDVEDLTKETLHKQYQLVKSHTNTSHVMQYGNKSISAMKLMQFQGLKHQASSPISLPAVSRLDLTPSPEVPLSIMKRKLMSTNDLQESRRLVQKIDRHLEARNIIEKSVRKIVTLVSGSAAEVDRLLSQRAPLTEHACYQTAVSHFRSHCFNWHNPTYEYALRHLYVLVNLCENPYPIDRIKLSMNKVCHGYY
What is the function of this protein?
Has a strict specificity for hydrolysis of asparaginyl bonds.  Can also cleave aspartyl bonds slowly, especially under acidic conditions.  Required for normal degradation of internalized EGFR.  Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity).  Required for normal lysosomal protein degradation in renal proximal tubules.  May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
What are the official names of this protein?
Legumain, Asparaginyl endopeptidase, Protease, cysteine 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C13 family.
Protein: CNG12_ARATH
Sequence: MNHRRSKFARIDSMGVDGKLKSVRGRLKKVYGKMKTLENWRKTVLLACVVALAIDPLFLFIPLIDSQRFCFTFDKTLVAVVCVIRTFIDTFYVIHIIYYLITETIAPRSQASLRGEIVVHSKATLKTRLLFHFIVDIISVLPIPQVVVLTLIPLSASLVSERILKWIILSQYVPRIIRMYPLYKEVTRAFGTVAESKWAGAALNLFLYMLHSYVFGAFWYLSSIERKSKCWRAACARTSDCNLTVTDLLCKRAGSDNIRFLNTSCPLIDPAQITNSTDFDFGMYIDALKSGVLEVKPKDFPRKFVYCFWWGLRNISALGQNLETSNSAGEIFFAIIICVSGLLLFAVLIGNVQKYLQSSTTRVDEMEEKRRDTEKWMSYRVIPEYLKERIRRFEDYKWRETKGTEEEALLRSLPKDLRLETKRYLYLDMLKRVPWLNIMDDGWLLEAVCDRVKSVFYLANSFIVREGHPVEEMLIVTRGKLKSTTGSHEMGVRNNCCDLQDGDICGELLFNGSRLPTSTRTVMTLTEVEGFILLPDDIKFIASHLNVFQRQKLQRTFRLYSQQWRSWAAFFIQAAWRKHCKRKLSKTRDNENIPQGTQLNLASTLYVSRFVSKALQNRRKDTADCSSSPDMSPPVPHKPADLEFAKAEA
What is the function of this protein?
Probable cyclic nucleotide-gated ion channel.
What are the official names of this protein?
Probable cyclic nucleotide-gated ion channel 12, Cyclic nucleotide- and calmodulin-regulated ion channel 12.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS16_BORRA
Sequence: MSVRIRLKRMGAKKRPYYRIVVMDSSSPRDGRAIEELGYYHPVERQNQVKINKNKFQEWVDKGAIPSDTVKRILNKSNFKVDN
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RL6_FLAPJ
Sequence: MSRIGKNPIAIPAGVTVEVNNSIVTVKGKLGQLTQNYTNNVTVKVEEGQVIVERAADSKQERAQHGLYRALINNMVAGVSTGFTKELELVGVGYRASNQGQKLDLALGFSHNIVLEIASEVTLETISEKGKNPIVKLTSFDKQLLGQVAAKIRGFRKPEPYKGKGVKFVGEVLRRKAGKSA
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RL18_SHIDS
Sequence: MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: GLPK_BACCZ
Sequence: MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIATCLSEADVKPEQIAGIGITNQRETAVVWDKTTGKPIYNAIVWQSRQTAEICDELKEKGYGEMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLLFGTIDTWLVWKLSGGKAHVTDYSNASRTLMFNIHDLQWDDELLDMLTVPKSMLPEVRPSSEVYGETIDYHFFGQNVPIAGVAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGMRMFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVRGAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGIELKTLRVDGGAVKNNFLMKFQSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAETSEELYAGWKKAIEATKAFK
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: SYS_CLOBK
Sequence: MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSEVPKLKKEGKDVSNIVAEMKNLSEEIKGFDATLAKIDEKIQYIMLRIPNIPNPQVPDGETDEDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKVTGSRFTFYKGLGARLERAVISYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTNLYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYRVVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILENYQSEDGSVTIPEVLRPYMGGREVIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPAH_PENBR
Sequence: MSTEKFTITEHLVPGSHIREYPGSTVNQQDVLKIHVKNYTPKREGPVPDDAITFIATHGVGLPKELYEPLWDELLDQASGFHIRAIWMADVASMNQSGIHNEDKLSMDCSWMDHARDLLLMINHFRDQMPRPLVGIGHSFGGNIITNLAYLHPRLFTTLLLLDPLIQLSPPSLGFGTDAPSAINYTLWRDDVWPSREEAIRANRAIMQGMDPRCLDRMTKHFFRDLPTPLYPDVEAIKARFGTTADSTTTPVTLTTPKYHELVAQIRQNFNARDPKTGRIEVPRDTHADMDPLVAYIPLYRPEPRSTFRRLETLRPSCLWVIAGATFLNIDEIREGVKICGSGIGGSGGVPDGRVREVVLPGFGHLMPFQEVKTVAGTCVVWLQQEMDRFRQTERQWKEDRDGKSHQAVEENWYKVLKPIPTGRKKRSDKGKL
What is the function of this protein?
Type I acyl-CoA thioesterase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (PubMed:21398490).  MpaH acts as a peroxisomal acyl-CoA hydrolase that converts MPA-CoA into the final product MPA (PubMed:21398490).  The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC.  5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE.  MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB).  MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP.  The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP).  The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate.  The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C.  After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight.  Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps.  The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process.  Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (PubMed:21398490, PubMed:22544261) (Probable).
What are the official names of this protein?
Type I acyl-CoA thioesterase mpaH, Mycophenolic acid biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MpaH hydrolase family.
What are the subcellular locations of this protein?
Peroxisome matrix. Note=The mpaH' location in peroxisomes is required for the unique cooperation between biosynthetic and beta-oxidation catabolism machineries to produce final MPA.
Protein: CIPKN_ORYSJ
Sequence: MSVSGGRTRVGRYELGRTLGEGTFAKVKFARNADSGENVAIKILDKDKVLKHKMIAQIKREISTMKLIRHPNVIRMHEVMASKTKIYIVMELVTGGELFDKIASRGRLKEDDARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDASGTLKVSDFGLSALSQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLMSLYKKIFKADFSCPSWFSTSAKKLIKKILDPNPSTRITIAELINNEWFKKGYQPPRFETADVNLDDINSIFNESGDQTQLVVERREERPSVMNAFELISTSQGLNLGTLFEKQSQGSVKRETRFASRLPANEILSKIEAAAGPMGFNVQKRNYKLKLQGENPGRKGQLAIATEVFEVTPSLYMVELRKSNGDTLEFHKFYHNISNGLKDVMWKPESSIIAGDEIQHRRSP
What is the function of this protein?
CIPK serine-threonine protein kinases interact with CBL proteins.  Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity).
What are the official names of this protein?
CBL-interacting protein kinase 23, OsCIPK23.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Protein: 3MGH_SYNE7
Sequence: MLESPWHPLLSQPATEAAIALLGCWLVRRFADGRVIRGRIVETEAYEAGDPACHGYRRQTARNRSMFGPPGQVYVYQIYGRYHCINLATEAADLASAVLIRALEFPDTEAIAGAGPGRLCRFLAIDRQLDGSWLGPTSPLDLEAADYPLGTLIQTTRIGLTRGVDLPWRWYLAESPAVSRRDRRAEAEQMGVSV
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: RECF_SHEHH
Sequence: MSLTRLHIETFRNISLAQLDPGDGLNLIYGQNGSGKTSILEAIYFLGMGRSFRSHLSQRVIQHNDDKLTLFANLSVCEQESKIGLRRFRNGETEVKINGDNIKRLSTLAETLPIQVITPESFSLLFEGPKSRRQFIDWGAFHSDKSFHLAWANVRRILKQRNQLLKNQVSYSQIQYWDKELVRYSEQVTEIRKQYVDSLNEQLKGIIGEFLPLVEVKVSFTRGWDSKTDFGQLLETQYLRDVAAGNTGSGPHKADLRLRVGVLPVQDALSRGQLKLLVCALRIAQGKLLKQQTDKNSIYLVDDLPSELDAQHRKLLLQQLMDTGAQVFVTAIEPAAIVDSLATPPSKMFHVEQGCVTVIDKPTRE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.