PharMolix/UniProtQA huggingface dataset:
Protein: BIOH_ECOK1
Sequence: MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLRQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGLEILKTVDLRLPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFISHPVEFHHLLVALKQRV
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VMPA1_TITFA
Sequence: DDCIVVEYYIVTDSAFTKRFKSNSALTKYVTVMFTGVQNLMDTLELGIGVRLLGVTAFNEETEPSFIIDNLISGPPEAFDPDVLITAMSEYYCNHQIGLAKNTDLIFLITARGMGDPREDGTVDINTAGIANSAGVYKPCLKAGVATDDSDYNERVDTLAHESVHLLGSPHDGEGPDQVSLEGSPGAANCPAKAGYIMGNRNDKNKYKFSPCTKKCVEYLLSKPAASCIFEQCSGF
What is the function of this protein?
Acts as a metalloprotease.  Penetrates intact tissue and specifically cleaves the vesicle-associated membrane protein 2 (VAMP2) (part of the SNARE complex) involved in pancreatic secretion, thus disrupting the normal vesicular traffic (By similarity).
What are the official names of this protein?
Venom metalloproteinase antarease-like TfasMP_A, VMPA.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family.
What are the subcellular locations of this protein?
Secreted.
Protein: KGUA_HAEIN
Sequence: MSQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKEEFESLIEQDLFLEYAKVFGGNYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVKSIFILPPSLPELERRLIGRGQDSEEVIAERMSKAMSEISHYDEYDYVIVNDDFEKTLKDLQSILQSERLTKDYQQKQNAMLIQQLLAK
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_AERS4
Sequence: MQEQYVPQSIEPAVQKHWDAKKTFKAVEKVDKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVISRYQRLNGKNVLQPIGWDAFGLPAENAAVKNNTAPAPWTYENIEYMKNQLKMLGLGYDWDRELATCKPDYYRWEQWFFTKLYEKGLVYKKTSSVNWCPNDMTVLANEQVVDNCCWRCDTPVEQKEIPQWFIKITDYAEELLNDIDNLEGWPEMVKTMQRNWIGRSEGVNISFAIEGQAEQLEVYTTRPDTFMGVTYVGIAAGHPLALQAAATNPGLAAFIEECKNTKVAEAELATMEKKGMATGLYAIHPLDGRKVPVWVANFVLMNYGTGAVMAVPGHDQRDHEFATKYGLDIKAVIKPADGEVDVSDAAYTEKGVLFASGEFDGLDFQGAFDAIANKLEALGHGKRTVNFRLRDWGVSRQRYWGAPIPMLTLADGTVVPTPEDQLPVLLPEDVVMDGIQSPIKADAEWAKTTYNGQEAFRETDTFDTFMESSWYYARYCSPDYDKGMLDPAAANHWLPVDQYIGGIEHACMHLLYARFFHKLLRDAGLVNSDEPFKRLLCQGMVLADAFYYKDEKGGNVWVSPTDVKVERDEKGRITKAIDNDGREVIHSGMTKMSKSKNNGIDPQLMVERYGADTVRLFMMFASPAEMTLEWSDSGVEGAQRFLRRLWRLTFEHVSAGAVPALDVAALTSEQKAVRRELHKTIAKVSDDVGRRQTFNTAIAAIMELMNNLAKLGSDEQDRALMQEALETVVVMLSPITPHIGFELWKMLGKGDDVDHATWPVADEAAMVETEKLVVVQINGKMRGKLTVPAEISQADVEKLAMADASVQKFTDGLTVRKVIYVPGKLLNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_PHATC
Sequence: MVKTNLNKGYVTQIIGPVLDIKFSEGNLPPIYSAIKIILDDNTETIVEVQQLLGDNKVRAVSMRSTDGLKRGVEAIDLGTPINVPVGTPTLGRIFNVIGEPVDEQGEVKYDETLPIHRDAPAFTELETKPSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYEEMKESGVINEKNFAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNKQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGALQERITSTTQGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQVGIVTEEHYATAENVKETLQRYKELQDIIAILGIDELSEEDRLTVARARKVERFLSQPFFVAEIFTGSPGEYVSLEDTIKGFLMVLNGELDDLPEQAFYLVGNIDQAIAKAETLK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: GPR85_HUMAN
Sequence: MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKSRLPREPYCVI
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 85, Super conserved receptor expressed in brain 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Protein: PROA_CYAP4
Sequence: MSVTATPVNLTELAHRTRQAARDLAGLSPTARNQALEAVARSLENASDEILAANQTDCRLATETGLAPALYSRLKLDSTKLAGAIAGVRSVSQLADPIGAVQLQRELDTGLILKRMTCPLGVLGVIFEARPDAVVQISALAIKSGNGVLLKGGQEALHSCKALVAAIHQGLASAGLNPDSIALLTSREETLALLELDQQVDLIIPRGSNAFVRFVQEHTRIPVLGHAEGICHLYVDQTADLEQAVQIAIDAKTQYPAACNAIETLLVHRAIAPQFLPQLATALQALKVELRGDELTREIIPVAPAAESDWATEYSDLILSIKVVADLESAINHINTYGSRHTEAIVTADENAATTFLHEVDAAGVFHNCSTRFADGFRYGLGAEVGISTHKLPPRGPVGLEGLVTYKYQLVGQGQVVSTYSGPSAKPFTHRDL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_BRUA2
Sequence: MAQTHSFNGRKRVRKFFGKIPEVAEMPNLIEVQKASYDQFLMVEEPSGGRPDEGLQAVFKSVFPIQDFSGASMLEFVRYEFDPPKFDVDECRQRDLTYSAPLKVTLRLIVFDIDEDTGAKSIKDIKEQDVYMGDMPLMTDNGTFIVNGTERVIVSQMHRSPGVFFDHDKGKTHSSGKLLFAARVIPYRGSWLDIEFDSKDIVYARIDRRRKLPATTLLMALGMDGEEILSTFYKTVTYTRDGDNWRIPYSAERFKGMKIISDLVDADTGEVVLEAGKKLTARAAKQLAEKGLKAIKATEDDLFGSYLAEDVVNYATGEIYLEAGDEIDEKVLKTLIDTGETEINVLDIDHVNIGAYIRNTLAVDKNESRQEALFDIYRVMRPGEPPTMDSAEAMFHSLFFDSERYDLSAVGRVKMNMRLDLDAEDTVRVLRKEDILAVVKMLVELRDGRGEIDDIDNLGNRRVRSVGELMENQYRVGLLRMERAIKERMSSIEIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATFARVNKYGFIESPYRKVVDGKVTNDVVYLSAMEEAKHSVAQANVELDEQGGFVDEFVICRHAGEVMMAPRENVDLMDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVRAEAPFVGTGMEPIVARDSGAAIAARRGGIVDQVDATRIVIRATEELDPSKSGVDIYRLQKFQRSNQSTCINQRPLVRVGDRIHKGDIIADGPSTDLGDLALGRNVLVAFMPWNGYNYEDSILLSEKIVSDDVFTSIHIEEFEVAARDTKLGPEEITRDIPNVSEEALKNLDEAGIVYIGAEVHPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSMRMPPGTYGTVVEVRVFNRHGVEKDERAMAIEREEIERLAKDRDDEQAILDRNVYGRLADMIDGKVAAAGPKGFKKGTTITRELMTEYPRSQWWQFAVEDEKLQGELEALRSQYDDSKKLLEARFMDKVEKVQRGDEMPPGVMKMVKVFVAVKRKIQPGDKMAGRHGNKGVVSRILPVEDMPFLEDGTHADIVLNPLGVPSRMNVGQILETHLGWACAGMGKKIGELLDVYRKTANIEPLRQTLEHIYPDNDRNEPVRSYDDDAILMLANQVKRGVSIATPVFDGAVEADINAMLTDAGLATSGQSTLYDGRTGEPFDRQVTMGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYEAIVRGDDTFEAGIPESFNVLVKEMRSLGLNVELDDTREAEQPALPDAAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: DTD_ACTP7
Sequence: MIGLIQRVKWAKVEVEGQTVGEITQGLLVLLGVEQGDDQAKADKLLEKVLNYRVFSDEQGKMNLNVQQAGGSLLVVSQFTLAADTNKGLRPSFSRGAAPQEANALYEYFHQQAARKIHTQTGQFAADMQVSLQNDGPVTFWLQI
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDC_ECOSM
Sequence: MDRIIEKLDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLVQQQRRHDMGSVRQVIDLDVGLFQLAGRGVQLAEFYRSHKYCGYCGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGEIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCRAEYE
What is the function of this protein?
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.  The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing.  Has preference for mRNAs with a 5'-end purine.  Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
What are the official names of this protein?
NAD-capped RNA hydrolase NudC, DeNADding enzyme NudC, NADH pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudC subfamily.
Protein: RL31B_XANC8
Sequence: MKDNVHPSYNDVVFHDVTSDFKILTRSTMSSKETVKWEDGQDYPLIKVEISSASHPFYTGKHKVIDTGGRIDKFQKRYAR
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: MUTL_LEVBA
Sequence: MPKIHELASVLADQIAAGEVVERPASVVKELVENAIDAHSTQIDITVEEAGLQRIVVVDDGDGIADEDSEMAFKRHATSKITDRRDLFRIKSLGFRGEALPSIASVADVTLITSTGGVGTEIHNVGGIIQEHKAAEARKGTTVIVKELFGNVPARLKYLKSPATELARITDIVNRLALSYPTVAFSLVHNGRELTRTTGRGDLQQVIAGIYGVQSARKMVAISGQNPDFRVSGYVSLPELTRASRQYISLLLNGRYIHNFQLSKALIAGYGSKLMVGRYPLAVLDIQMDPLLVDVNVHPTKQEVRISQEAELTQLIQETVFKRLSQENLIPDVFDEVQTKQPETKTTDQLTMALNDVSAKYDMSDRQVLGAQQMPSESVAQPSDAAPVATSMGQPAPLQTPEEVPVEPVVVHDKRDFATPAVQRFDAKYRQEQVAAPLGQSAASAAVDQPAVEATAPIEPVQATPAQRFPTLRYLGQVHGTYLLAEADDGLYLVDQHAAQERVNYEFYRQAIGEVSDDEQKLLVPIVLDYPTTDVLELTNHLETLASVGIHLDSFGPNSFIVHEHPTWFKAGQETATIQEMIDWVLKDGKISVAAFREKTAIMMSCKRAIKANHHLDDQQARALLQKLATAENPFNCPHGRPVLVHFTDQDLEKLFKRIQDPHHSGDDWEEA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: COAD_HELP2
Sequence: MQKIGIYPGTFDPVTNGHIDIIHRSSELFEKLIVAVAHSSAKNPMFSLKERLKMMQLATKSFKNVECVAFEGLLANLAKEYHCKVLVRGLRVVSDFEYELQMGYANKSLNHELETLYFMPTLQNAFISSSIVRSIIAHKGDASHLVPKEIYPLISKA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUMPK_ARATH
Sequence: MAIPLPLTSCSPISTSSSISRTSFVPLTLRNRTFFSNQNYSRRVLISCSSSLSSDNGSSPDSMNGNGNGNGSSLNGQSSFPRLPSFDGTSKPPLKWRRVLLKVSGEALAGDEEQNIDPKVTMAIAREVAAVTRLGIEVAIVVGGGNIFRGSTWAGCSGLDRSSADYIGMLATVMNAIFLQATMESIGIPTRVQTAFRMSEVAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFTTDTAAALRCAEINAEVVLKATNVDGVFDDDPKRNPNARLLDSLTYQEVTSKDLSVMDMTAITLCQENNIPVVVFNLSEPGNIAKAIKGERVGTLIGGTWNSIVTTTS
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP (PubMed:30409856).  Required for specific post-transcriptional processes of many plastid transcripts (e. g.  PSI (PsaA, PsaF), PSII (D1, CP43, CP47), Cytochrome b(6)f (Cytb(6)), ATP synthase (AtpC), LHCs (LHCa3, LHCb2), and NDH (NdhH)), thus being essential for retaining photosynthetic activity in chloroplasts (PubMed:19037728, PubMed:30409856).  Associates with group II introns of the plastid transcripts trnG-UCC, trnV-UAC, petB, petD and ndhA to stabilize corresponding precursor RNAs (PubMed:30409856).
What are the official names of this protein?
Uridylate kinase PUMPKIN, chloroplastic, Plastid UMP kinase, Protein DEFECT IN PSAA/B TRANSCRIPT ACCUMULATION 1, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: LEXA_ACTSZ
Sequence: MSLVKPLTARQQEVYNFLKHYIETTGMPPTRAEISRELGFRSPNAAEEHLKALARKGAVEILAGTSRGIRLLLDAANDEPEGLPLIGQVAAGEPILAEQHIEGTYRVDPDMFKPQADFLLKVNGQSMKNIGILDGDLLAVHSTKDVRNGQVIVARIEDEVTVKRLERKGDVIYLHAENEEFAPIVVNLREQERFEIEGIAVGIIRNNAWM
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: GLYA_SHEB8
Sequence: MLKKDMNIADYDPELFKAIQNETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVVETLAIERAKELFSATYANVQPHSGSQANSAVYMALLKPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIIPYGIDESGKIDYDEMERLAVEHKPKMMIGGFSAYSGIVDWAKMREIADKIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTSTTHKTLAGPRGGVILSAADDEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKVYQQQVVNNAKAMVEVFLERGYKIVSGGTSNHLMLVDLIGRDLTGKEADAALGSANITVNKNSVPNDPRSPFVTSGVRIGTPAITRRGFKEAESKELTGWICDILDDANNPAVIERVKGQVLALCARFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_AERPE
Sequence: MKRPRSRLWYDGLENTPHRVYLRAIGFTSDDFQKPLIAVVAAWSEAGPCNFNVLPGSLRVKEGVRSAGGVPLAVPTIVVNDGINMGTPGMRYSLISRELIADTIEAQVASHGFDGWVGIGGCDKTQPGIMMAMARLDLPSIYIYGGTAEHGVLDGETVTVQSAFEAVGAYLKGLIDEERLYEIEKAAMPTPGTCQGLFTANTMAILAEALGLSPLGSASPPATSSERARELARAGALAVGLVETGLTPRRILTYEAFYNAIVTLMAISGSTNAVLHLLAIAREAGVKLALDDFDEASRKVPVIAALAPAGKYTMVDLHNVGGAPVILRKLLDRGLLYGEAVTVEGVEIGKLLSKWEPRTDYNILYDFDKPYKPHAGLRILRGSLAPRGAVMKIGASGILKFKGAAKVFDSEEEAFKAIERGYVEEGDVVVVRYVGPKGAPGMPEMLKITAAIVGAGLGEKVALITDGRFSGATRGVMVGHAAPEAAVGGPIALVENGDEIVIDGEKGTLDVLLGGDELARRRDKWSPPPLPKQGLLRKYAKLVTQADEGAVTH
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: SODF_LEPBY
Sequence: MAFTQPPLPFPKDALEPYGMKAETFDYHYGKHHAAYVTNLNKLVEGTPMESLSLEDVIKQSFGDSSKVGVFNNAAQVWNHTFFWNCLKAGGGGAPTGELAAKIDAAFGSLDKFKEEFSNAAATQFGSGWAWLVDDGGTLKVTKTPNAENPLVHGQKPLLTLDVWEHAYYLDFQNARPAFIKNFLDNLVNWDFVAQNLAA
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Fe].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPS4_ISORU
Sequence: MSSSSIVTSLLRPTTAADGVLPRQMAQVNSSCNIWRSKAKVGGINYFNPGNIKCVEEVHKSRQVVVAALKSLEYETEKPTNQDVVSEKMRVLSERIETMLQNMDEGEISISPYDTAWVALVEDTDGRPQFPTSLEWISNNQLADGSWGDRKFVIYDRILNTLACVVALTTWNMHPHKCNRGLRFIRDNMEKLENENEELMPIGFEVVFPSLIEAAQKLGIEIPHIDSPCIKKIQAMRDFKLKRIPMELLHKKPTSLLHSLEGMQGLVWEKLLDFRSDGSFLCSPSSTAYALQHTKDELCLQYLLKAVKKFNGGVPNVYPVDMFEHLWCVDRLQRLGICRYFRVQIKEMLDYVYKYWTDKGICWARNTNVQDVDDTAMGFRLLRMHGYDVSTDVFKQFEKAGEFCCFPGQSTHAITGMYNVYRTSQIMFDGEDILADAKNYSATFLHQKRLANELVDKWIITKDLPGEVGYALDVPFFASLPRLEARFFLEQYGGDDDVWIGKTLYRMPYVNSDTYLELAKLDYKKCQAVHQLEWKSIQKWYRDCKLGEFGLGEKRLLLAYFLAASTAFEPEKKGERLAWAKTAFLVETIASQQLSHEQKREFADEFEHGSSLNMENGGSYKTRTRLVEILSNTVSQLSFETLVAEGRDIKQQLSNTWQKWLKTWEEGGNLGEAEAQLLLQTLHLSSGLDESSFSHPKYHQLLEVTCKVCNQLRLFQNRKAHDAQGGISDLVIGTTFQIEASMQELVKLVFTKSSEDLDSITKQSFFAIARSFYYTAYCDAGAINSHIYKVLFENID
What is the function of this protein?
Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities (PubMed:28381502).  Catalyzes the conversion of (2E,6E,10E)-geranylgeranyl diphosphate (GGPP) to ent-copalyl diphosphate (ent-CPP) (PubMed:28381502).
What are the official names of this protein?
Ent-copalyl diphosphate synthase 4, Terpene synthase 5, IrTPS5.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsc subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MYPN_HUMAN
Sequence: MQDDSIEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDLPDLSAFLSQEELDESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL
What is the function of this protein?
Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
What are the official names of this protein?
Myopalladin, 145 kDa sarcomeric protein.
What is the protein family that this protein belongs to?
Belongs to the myotilin/palladin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Bound to sarcomere both at the Z-line periphery and in the central I-band region.
Protein: H2B1_PONAB
Sequence: MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Has broad antibacterial activity.  May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid (By similarity).
What are the official names of this protein?
Histone H2B type 1.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RS3A_MACFA
Sequence: MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGHVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGSSSGKATGDETGAKVERADGYEPPVQESV
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).  May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity).
What are the official names of this protein?
40S ribosomal protein S3a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: HDA_SHIFL
Sequence: MNTPAQLSLPLYLPDDETFASFWPGDNSSLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECIAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.