PharMolix/UniProtQA huggingface dataset:
Protein: LIGO1_PONAB
Sequence: MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPGGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI
What is the function of this protein?
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors.  Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.  Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
What are the official names of this protein?
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: CYAA_SCHPO
Sequence: MDQSKRLLKSAVPNPPEHFKTGISWLDDLDEKDDDSATSVNYDIPEITEANLCNDSHEALSPCTQPVGNSGRPVEAFKTYPSTPAVPSKSVLFHFYEPDENFSLSDTGRTKSDTALAARESSEKSEVPRDTRSAGIKPYKENNSSNCAISKEAGLRRLIDKDRESFDKNLNQSFTNLTFPEPISDDSDSVEFQRDSLNNNWPASLEGSIHELPRNSDDDGIPASAAHILDLDYHRDSYDSPWKKFLPYPSILSDDSWKAPESWGTSLPTEAIPKQVFTTRFFARPSLGNRKKEFFLRVYRDDRTSVSFICPIGIQTHEVIKLLARLFFLPSSANFYLLLIQFNTERILLPHEQPCIIFERLLSLFGCKVTSDEEINEEDNYSVARLVFTTMDIGADVLRKFSEKKITANLDISRSNLEVIPVKIYPYAHELISLNVSHNLSLDLPLDFMERCVKLKRLDISNNLRSPRGKPITALRQLEVLNMSRNDIYELDPLIFSGLSRNSLKELNIANNKLFFLPHSTRYLVNLTYLDLSYNNFVTFPLIITELSQLETLNFSHNLLSQISSKIGSLVKLKHLYLQFNDLSNRLPQEIGLLKNLETIDLSYNAITNIASLSECPKLNSINVACNLLSFYEYSNPSATFIDFSFCPLTTIDPAFSYSNLVYFDISHAKLIGLKDSVIETLVNVETVKVNYNHFTSISDAISAMQNLKYLSCTNCEMSYVSPNLGKLKHLVHLDLHANNIKIFPEEVWQVSSLKVVNLSSNILEKIKLPVATSKKLTRTISQLKIMRTLSGNPVSSLSSQEFVMPTVEELYLVDNRLGNDCFTALEYFKCLKVLNLSYNYLTEIPSKFFQNFSDLKHLFVSGNELANLSISSTAQVLLETLYANGNRLSSFPKNEALSKSLRFLDISTNNLQNLAVEKAEKKSLTKLPQLEYLNLSGNTWFRFSEHEDTNFTKSYLKNLKFLSIMDLNTKFSNAPSDVLNHFIQRNSPQPNILRYGVCGYLSRSIPVISACELVVNNFLHPQSSLYCVLDSDISAGKNNRVLKFVYDNLASCLAHEINAADSSSEQICNALRRGFLRLNKKLGNVIHYDLRKSSEGDVDSNYVTTMNISEKGYSMDSSCLDIGVSIILVYVRDTRAFVANVGTSMAIMSTRNDSEPTTLSVMHDVYNRDEIRRIVDSCGFISGEIKSTTTRAIGRLSQFPGVQAVPYVNVQYLSELNEFIILANQEFWSVLSKRTVIDVVRANRHSPLLASTKLRDYAIAYGAEKNVLVVIVELNGLFEENSLNFNQLRGDEKTLAISEKNDNMSFVQDLPDDSSLARMNREVSPPKGCIAMVFTDIKNSTLLWERHPIAMRSAIKTHNTIMRRQLRATGGYEVKTEGDAFMVCFQTVPAALLWCFSVQLQLLSADWPNEIVESVQGRLVLGSKNEVLYRGLSVRIGVNYGVTVSELDPITRRMDYYGPVVNRTSRVVSVADGGQIAVSAEVVSVLNQLDSETMSSEKTNVNEMEVRALKQIGYIIHNLGEFKLKGLDTTEMISLVYPVQLQGRLERLIKSRSLGTPTALPETQTYTPVRSRSNSLRPMLARLSDSKSVHGEEGGSGKRSVSSLRNVSPSESTGGYEGCIFDDQQYQLLYELCERLEDHAAILHGFPEPPPCDTGLAAPVNQAEEYSLFYRLTLRIENTIYCVSQMLGHTG
What is the function of this protein?
Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
What are the official names of this protein?
Adenylate cyclase, ATP pyrophosphate-lyase, Adenylyl cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAIB_PARMW
Sequence: MSPRKTYILKLYVAGNTPNSMRALKTLRNILETEFRGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRRIIGDLSDRERVLIGLDLLYDELADNAFSSG
What is the function of this protein?
A metamorphic protein which reversibly switches between an inactive tetrameric fold and a rare, thioredoxin-like monomeric fold (KaiB(fs)).  KaiB(fs) binds phospho-KaiC, KaiA and CikA.  KaiA and CikA compete for binding to KaiB(fs), and KaiB(fs) and SasA compete for binding to KaiC, thus the clock oscillator and output signal pathway are tightly coupled.
What are the official names of this protein?
Circadian clock oscillator protein KaiB.
What is the protein family that this protein belongs to?
Belongs to the KaiB family.
Protein: GT7_ARATH
Sequence: MVSPETSSSHYQSSPMAKYAGTRTRPVVCISDVVLFLGGAFMSLILVWSFFSFSSISPNLTVKNEESSNKCSSGIDMSQDPTDPVYYDDPDLTYTIEKPVKNWDEKRRRWLNLHPSFIPGAENRTVMVTGSQSAPCKNPIGDHLLLRFFKNKVDYCRIHGHDIFYSNALLHPKMNSYWAKLPAVKAAMIAHPEAEWIWWVDSDALFTDMDFTPPWRRYKEHNLVVHGWPGVIYNDRSWTALNAGVFLIRNCQWSMELIDTWTGMGPVSPEYAKWGQIQRSIFKDKLFPESDDQTALLYLLYKHREVYYPKIYLEGDFYFEGYWLEIVPGLSNVTERYLEMEREDATLRRRHAEKVSERYAAFREERFLKGERGGKGSKRRPFVTHFTGCQPCSGDHNKMYDGDTCWNGMIKAINFADNQVMRKYGFVHSDLGKTSPLQPVPFDYPDEPW
What is the function of this protein?
Probable glycosyltransferase that may be involved in the biosynthesis of xyloglucan.
What are the official names of this protein?
Putative glycosyltransferase 7, AtGT7.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 34 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: BIOB_METFK
Sequence: MRDSVIDIRGLDRVQRARVQAKEEAPKRWSVDDIVALFELPFSDLMHRAQSVHRENFDPNGVQVSTLLSIKTGGCSEDCGYCPQAARYHTDVEKQDLMQLEEVLAAARAAKENGASRFCMGAAWRSPKQRDLEPVLAMIREVKAMGLETCATLGMLKDGQAEQLKEAGLDYYNHNLDTAPEYYGEVITTRTYQDRLDTLDRVREQDINVCCGGIIGMGESRVQRAGLLAQLANMERPPESVPINLLTQVEGTPMYGMDELDPFEFVRTIAAARITMPQSFVRLSAGRQSMHEGIQALCFLAGANSIFYGEKLLTTGNPEAEADRKLFDKLGIHPL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: VATD_METBU
Sequence: MGAKEVKPTRSELIELKKKIKLSEGGHKLLKMKRDGLILEFFDILSKAKDVRSELDAAYEKANVKIGIAESVEGRITIKSTAFAMKDAPQIVLESHNIMGVVVPKIESSSVRKPINKRGYGLLGTSSYIDEAVDSYEELVEKIILAAEIETTMKKLLDDIEKTKRRVNALEFKVIPELTEAMVFIRLRLEEMERENTFRLKRIKKA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: ATP6_BORPA
Sequence: MAAPSGASPQSEYIQHHLVHLNNIGEKQSVIAQFNVINYDSLFWSILMGLLVVFCLWLAARRATAGVPGRFQGFIEMIVDMVDDQAKSIVTNAKSRLFVAPLALTVFLWIILMNALDLLPVDLLPSIWRMTGLGAEHGDPLYYHRILPTADLNVPMGMSLGVLLLMFYYGIKIKHPGGFVKELFTAPFHAHGLASLVLAPFNLLLNLIEYAAKSVSLGMRLFGNMFAGELIFMLIALLGGAWTGFNGASIGLGIGHVLAGSVWAIFHILIVLLQAFIFMMLTLVYIGQAHEGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPD_YERPB
Sequence: MSNFAVSLPEVIAVLPAAGIGSRMLADCPKQYLTVGGKTIIEHAIFSLLHHPRIQRVIVVIHPQDTQFSRLSVAQDPRISTVYGGDQRANSVMAGLQLAGQAEWVLVHDAARPCLHLDDLSRLLSITECSQVGGILAAPVRDTMKRAEPGIQAIAHTVDRQDLWHALTPQLFPLELLKLCLSRALREGVAVTDEASALEHCGYHPILVTGRSDNIKVTRPEDLALAEFYLTQRQSLNNDSL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: Y1899_THENN
Sequence: MKKIKSFGGKSLGGGKQEKLLKDFMKMQEELQKKMQEMEESFSEMEVEASVGGGAVRIVATCDRRVKEIEIDEDLKEDLETLKDLLAAAVNEIMEKIEKRREEEMSKITQQFGIPGLM
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein CTN_1899.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MOAA_ECOSM
Sequence: MASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPSGVTNKGFLTVDEIRRVTRAFASLGTEKVRLTGGEPSLRRDFTDIIAAVRENDAIRQIAVTTNGYRLERDVANWRDAGLTGINVSVDSLDARQFHAITGQDKFNQVMAGIDAAFEAGFEKVKVNTVLMRDVNHHQLDTFLNWIQHRPIQLRFIELMETGEGSELFRKHHISGQVLRDELLRRGWIHQLRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSIGKLHLCLFGEGGVNLRDLLEDDTQQQALEARISAALREKKQTHFLHQNNTGITQNLSYIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: FEN1_ASPFC
Sequence: MGIKHLFQVIQENAPDAIKAGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTARKAEATEAHEEAKETGTAEDVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLNRALEGLGMDRKQFIDLCILLGCDYLEPIPKVGPNTALKLIREHGSLEKVVEAIENDPKKKYVIPEYWPYQDARELFLHPDVREADHPECDFKWEAPDVEALVEFLVKDKGFNEDRVRNGAARLQKNLKTAQQSRLEGFFKPVARTDEEKASLKRKHDEKLQEQKKRKKEEAKAKKEAKAKPRGAA
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: ASNA_CLOPE
Sequence: MEKLFIPKGYKPLLSLRETEVAIKELKDFFEDSLAKNLNLTRVSAPLFVNKGSGLNDDLNGIERPVSFDMKAMPEFNIQIVHSLAKWKRLALHRYEFEHGEGLYTDMNAIRRDEDLDNIHSIYVDQWDWEKIIDKEERNLETLKETVKSIYGTFKATEDFIVAKYPHIEKILPEDITFITSQELEDRYPDLTSKERETAICKEFGAVFIIGIGGKLASGEKHDDRSPDYDDWTLNGDLLFYYPLFDEAVELSSMGIRVDEESLLKQLKIAECEERKELPFHQMLLEGKLPYTIGGGIGQSRICMFFLRKAHIGEVQASMWDEDMIRTCEENNIHLL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELO_SHEDO
Sequence: MDAPSRSHLASPILVANYRSLPSFMYRDSLPEAAVSPQLLALNTRLLETLEQDLAWFNSSDALEQLSGKTYYGSNLPFALAYSGHQFGGWSPVLGDGRAHVLGQLKTAADELIDVQLKGSGATPFSRGGDGRATLGAVIREYLLSEAMAGLNISTTGSLAVIATGEDVWRNGAYPGAILVRTAKSHLRVGSFQYAAVHQGPEAVKTLADFALAQYYPELSHDENPYQALLAQVIKGQAELVAQWMLVGFIHGVMNTDNSSITGETIDYGPCAFMDEFNPNKVFSSIDSQGRYAWGNQGAIAQWNMARLGETLLPLLDSDEAKALEIAQAQLGDFNRLFAEHFYQGMARKLSLDASDPELIPFVDSTLQLMTNTRVDFCQFFNALTEYHSTHREQDAGLVALFSTEAFPSLSSTPAQLLQDWLSQWQAKACDSQAALAAMIKANPKFIARNHKVEAAISAAEQNNDYSLFLDMARVLANPYVLAEQDKHYQDAPTPDQRVKQTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: YIDD_BURMA
Sequence: MQTVLIALLRFYKLAVSPLLGSRCRFYPSCSDYAREAIQYHGAARGTYLAARRLCRCHPFSAGGVDLVPPPNSDARNAPHEAEASSHRL
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACCA_ACTP2
Sequence: MSQEYLDFELPIAELEAKIESLRAVSEQDGKIDLDDEIKRLQKKSEELTKKTFANLDAWQVSRMARHPNRPYTLDYIEHIFTEFDELAGDRAFADDKAIVGGIARLDGRPVMVIGHQKGRTTKEKVRRNFGMPAPEGYRKALRLMEMADRFNMPIITFIDTPGAYPGIGAEERGQAEAIARNLREMAQLKVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSAEKASTAAEVMGLTAQRLKELNLIDSIVAEPLGGAHRDVAQMAENLKQQILADLQDLAPLSTEDLLDRRYQRLMSYGYV
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFH_ECO5E
Sequence: MPGKIAVEVAYALPKKQYLQRVTLQEGATVEEAIRASGLLELRTDIDLTENKVGIYSRPAKLSDSVHDGDRVEIYRPLIADPKELRRQRAEKSANK
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: AAR2_CAEEL
Sequence: MGGALPPEIVDYMYRNGAFLLFLGFPQASEFGIDYKSWKTGEKFMGLKMIPPGVHFVYCSIKSAPRIGFFHNFKAGEILVKKWNTESETFEDEEVPTDQISEKKRQLKNMDSSLAPYPYENYRSWYGLTDFITADTVERIHPILGRITSQAELVSLETEFMENAEKEHKDSHFRNRVDRENPVRTRFTDQHGLPIMKIREGYEIRFQDIPPLTVSQNRVGIEYSDRLYRLLRALGGDWKQLLAEMQIAFVCFLQGQVFEGFEQWKRIIHLMSCCPNSLGSEKELFMSFIRVLFFQLKECPTDFFVDIVSRDNFLTTTLSMLFANVRDSAHAGDDLKKKTAQFKQYLTNQFKWDFNCD
What are the official names of this protein?
Protein AAR2 homolog, AAR2 splicing factor homolog.
What is the protein family that this protein belongs to?
Belongs to the AAR2 family.
Protein: SELO_BACAA
Sequence: MTKNNEAGWNLDHSYTTLPQSFYTEIPPTPVSSPELVKLNHSLAISLGFNPEELKKEAEIAIFAGNALPEGAHPLAQAYAGHQFGHFNMLGDGRALLIGEQMTPSGKRFDIQLKGSGPTPYSRRGDGRAALGPMLREYIISEAMYALDIPTTRSLAVVTTGEPTYRETKLPGAILTRVASSHIRVGTFQYAAARGSIEDLQSLADYTIKRHYPEIEAHENRYTALLQEVIKKQASLIAKWQLVGFIHGVMNTDNITISGETIDYGPCAFMDNYDQGTVFSSIDTQGRYAYGNQPYMAAWDLARLAESLIPILHEDEEEVLKIAQDEISKFSVQYEKQWFLGMKKKLGLFSNEEQDQSLIEQLLKMMEKFKADYTNTFRSLTLNTIENTALFESPEFKEWYKLWQSRLERQEESKENAYEMMKNNNPSIIPRNHRVEEALEAAVTNGDYSVMEKLLEALSNPYAYATEQEEYCVPPVPTNRPYRTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: RUVB_BURM1
Sequence: MIETDKLAAERIIAATPASSHEEVFERALRPRQLDDYVGQEKVRGQLEIFIEAAKRRREPLDHVLLFGPPGLGKTTLAHIIAREMGVNLRQTSGPVLERAGDLAALLTNLEANDVLFIDEIHRLSPVVEEILYPALEDYQIDIMIGEGPAARSVKLDLQPFTLVGATTRAGMLTNPLRDRFGIVARLEFYDADQLSRIVQRSASLLNAQIDPNGALEIAKRSRGTPRIANRLLRRVRDYAEVKADGQITAAIADAALAMLDVDPVGFDLMDRKLLEAILHKFDGGPVGIDNLAAAIGEERDTIEDVLEPYLIQQGFLQRTPRGRVATLLTYRHFGLAAPDAGSPVQSIWDTPDAQ
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: AROB_PELPD
Sequence: MSVLTVNLGENSYDILIDGGTLPSLGRHCLERGLSGRVAVISNPAVAELYAEQVRASLVESGNQVTLILIPEGEEHKNAATLNLVYDQLIQAGLDRNSYIVALGGGVVGDLAGFAAATFLRGIPFVQVPTTLLAQVDSSVGGKTAIDHPRGKNLIGAFYQPRLVLIDVETLTTLPQREFRAGLAEVIKYGVAMDLAFYELLERDSGRILEMDADCLERIVLRCCELKARVVEQDEKESGLRAILNYGHTLGHAIETLAGYGTLVHGEAVAIGMVLAARISLAGGYCSEGDVSRIVALLGRFGLPCIPPRIDQGRLAETLLTDKKSRSGIIRFICNRGIGDCVVVNLTAEQLLTLSGLEV
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_STAAM
Sequence: MRVEVGQIVNTHGIKGEIKVKSNSDFTDVRFQPGQVLTVVHNNNDLEYTVKSHRVHKGLHMLTFEGINNINDIEHLKGSSIYQERDHEDIVLEENEFYYSDIIGCTVFDDQETPIGRVINIFETGANDVWVIKGSKEYLIPYIADVVKEVDVENKKIIITPMEGLLD
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_SALDC
Sequence: MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHIGQMLLTRADMEDRERFLNARDTLRALLDNHIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQQGLFTADPRSNPQAELIKDVYGVDDALRSIAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIASGSKPGVIGDVMEGISVGTRFHAQASPLENRKRWIFGAPPAGEITVDEGATAAMLERGSSLLPKGIKSVTGNFSRGEVIRICNLQGRDIAHGVSRYNSDALRRIAGHHSQQIDAILGYEYGPVAVHRDDMITR
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_FRATM
Sequence: MNLLRPKLKYFILAILIIAADLYTKYLANTYLEFAQSLKITSFFNLTLLYNHGAAFSLLSNDQTSWQMIMFSTISLIAAIVLIYLIIKQPITEKINLFSFALILGGALGNFYDRAFQGYVIDFLDFHIGNYHWPSFNIADSAITCGVVILIAASLFTKKKS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MDH_METMA
Sequence: MVKISVIGAGNVGSTTVQRLAELEPGEIVMTDIVEGMPQGKALDLMQAGAINGYDTRITGTNDYADIANSDLVIITAGIARKPGMSREDLIKTNSKIIGDVAGNIAKYAPNSIVINVTNPLDIITYVAMKATGFDPEKVFGMSGVLDAGRFASFIAEELKCSKRDVEAMVIGGHGDLMVPLPQYTTVSGIPLPELLPEKTIDRLVERTVNGGAEIVELLKQGSAFYAPSAAIVRMAEAVIKDSRRVLPASAYLEGQYGQKGIYFGVPVKLGANGIEEILELKLEDSQCEILKKSSETIRKGISKLEI
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily.
Protein: DHE4_NEUCR
Sequence: MSNLPSEPEFEQAYKELAYTLENSSLFQKHPEYRTALTVASIPERVIQFRVVWEDDNGNVQVNRGYRVQFNSALGPYKGGLRLHPSVNLSILKFLGFEQIFKNALTGLSMGGGKGGADFDPKGKSDAEIRRFCCAFMAELHKHIGADTDVPAGDIGVGGREIGYMFGAYRKAANRFEGVLTGKGLSWGGSLIRPEATGYGLVYYVGHMLEYSGAGSYAGKRVALSGSGNVAQYAALKLIELGATVVSLSDSKGALVATGESGITVEDINAVMAIKEARQSLTSFQHAGHLKWIEGARPWLHVGKVDIALPCATQNEVSKEEAEGLLAAGCKFVAEGSNMGCTLEAIEVFENNRKEKKGEAVWYAPGKAANCGGVAVSGLEMAQNSQRLNWTQAEVDEKLKDIMKNAFFNGLNTAKTYVEAAEGELPSLVAGSNIAGFVKVAQAMHDQGDWWSKN
What are the official names of this protein?
NADP-specific glutamate dehydrogenase, NADP-GDH, NADP-dependent glutamate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: HISZ_PROMT
Sequence: MTLQPASGARDLNPQQVRKNHLIASKLSSLYQLWGYERISPPHIERLDTLTAAGGISNNEILKIVSDEPLGLRPEITASIVRAASTRFNEYERPLRFWSAGTSFKCNQSIDGGIDIEESFQSGVELIGTKAINAEIELLSLLIESLEVIEIDQKYKMTLLIGNTYLLELILSSFDSTKIDQIKKILSDLDYIALTTLDVKEEQRMFIKTIMNMRGKPEKVLTNLQNIYGSNSYIDKLEELFTIIEPLAKEKGIEVQLDPTLGTKYKLYSGLTFSLVSSSTSAPVTIAKGGRYDDLVKKFSSSAQNCYGIGFSISVDKVRELVSTSKEKLVNNVKVLIAYKQSANLYKALKQQKELHRKGIISVISHEPLKTIDETNQLLKTNRCNKIEWID
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_PARUW
Sequence: MRGHYHFIGIGGIGMSGLARILLQQNLSVSGSDIAFNYTIEGLIKSGATIYKGHSPSYITSGSTVIYSSDIKTDNPEYLAAKNLQCSLLHRAELLALLTRQKKSLAVTGTHGKTTTSSLLATTLLEANCDSSFAVGGIIPQFQSNAKHGLGDLFVFEADESDRSFLKYFPYGAIVTNIDNDHLNSYENSEDVLIQSFQQFTSQISSPNHLFWCGDDTHLKFLNGIGQSYGFGEHCNWRISNVFQKDFNLEFDLEGNEKKYPSIKLNLIGRHNLLNGAAVFGLAMSLNISEASIRHTFERFCGVLRRCEYKGEFENTIFLDDYAHHPTEIQTTLEGIRKAIKSKRLIAVFQPHRFSRIKDCLGMYGKIFNNADEVFVTDVYGAGETPIEGISQQQIIQEISENSSVPVKYVPRTALGHKLSEFIQPLDVIVTLGAGDVTKVASETLSLLENGKRF
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMHA_GEOSM
Sequence: MLEEIKAQLRAHCEVMTALQGELSPAIESAVSLVVDAYRAGNKLLVMGNGGSAADAQHFVAEMVGRFKLERRALPAIALHTDTSILTAIGNDYGFDRIFSRQVEAHAAAGDVVVGISTSGNSPNVQLALELAREKGCRTVALLGKDGGSIKSVAELPLIVPSNDTPRIQEGHITIIHIICDLVERELFLKGN
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.