Protein: AR283_ARTOA
Sequence: MTSTPATSLGDMDHEYNQDDIAIIGMACRLAGGIQSIEQFWNAILSKKDASGEIPEMRWEPYFRRDSRNAEILKKTTSRGYFLDRLENFDASFFGISPLEAELMDPQQRIALEVTWEALEHAGISVTSLAGSDTAVFMGVNSDDYSRLLLEDVPGVEAWMGIGTAFCGIPNRISYTLDLHGPSTAVDAACASGLVAVHHGRQALLAGESKLAIVGGVNALIGPGLTRVLDEAGAVTPEGRCRSFDDSASGYGRGEGASVLVLKRLSEAIIDGDKVLAVLKGSAVGQDGKTNGIMSPNQVAQEEVARKALSVARVDPLSVAFVEAHATSTPVGDPCEVAAIASVYGSGAGRPKDLPCKIGSVKPNVGHLEAGAGSTSLIKAVLAVSNGIFPPQANFQTPNRKMDWDNNSLEVIRGVSDWVQDRKRAGICSYGYGGTVAHAVIEQAPAPNFGPEDQVGDVVYADAAPYLLFWSAPQSQRLRETAAQLASWVGETEQPLADIANTLAYRRSQHQHRCAVVADNREEAVKLLELGSQNADSPWMIKEKVSNYGKKGAVWVFSGHGAHWTDMGKELLASEPAFYGAVSSIDNIVRDILNFSPLEALENGDLKTTDKQQVLTYAMQVGLSAVLRSKGAQPAAVIGHSVGEIAASVTAGCLTIQEGAFIVSQRAKLYRLVAGRGAMILVDLSPEDAVKELEEQGQTGAVAVAIHSSPNTCVLSGGIEAINELEQSLKDKHIQARRVKTDVAFHSPVLNELAEPLLELISGHIKPQQPKIRLYSTSLTQARGDNLRDEKYWIDNMIQPVLLTNAVKAALEDDFGIFLEVSSHPIIAHSINETIIEADSDGVIFPTLRRDKPSRKCILFALGKLHCHGAPIDLRANFSGDWTRDVPTTVWKHNPFWRKVGTGSLQPNKSVTHDVKSHVLLGAKHQVVGSDTTMWTTTLDESTRPFPGSHPLHGTEIVPAAVLLNTFLHTGEEYNALKDVILRVPVAMSAPRNIQIVKEQGRVRIVSRLQASEGENNNTESSWLTHTTGHVANNEWSKSSLDISATKKKLPSVKPSFATDYLASVGVPDMGFPWKVTEHYGEGDEMLSRVDTAPESSEKSIPWDVSSWAPILDAATSIGSSIFYKEPVLRMPAQIDEVAITPGSIPKVAYIHTTVETGMWRVNVAILNEEGHEVAHINGMRFSAVEGTPGASGSVESLVHQMSWPPAKLEEEGFQLKNVVFVSEQSDRVAAYIQDLQKRKVSTTVVPNPAGLEEQNLSSEGTIVAYLPSGSDLEEDTAKFSSTFCSEVLDIAKLLVNQKSPSKLWCITQGLFEAFSPSSLSQGPLVGLSRIIASEHPEVWGGLVDTDDESFPLQAVKYVKSVDVISVRDSVARVARLRPVPRSKIVTGREKTFTPTAEGTYLITGGLGALGLETAKWMVESGARRLILVSRRGLPPRRKWVDSNDDSAISTIRKLERLGASIHVVAADISKPDGAERLEQALDLLDLPSISGVVHAAGVLEDQLVAETTKESFDRVLAPKVSGAMALHQLFPPKTLEFFVLFSSCGQLLGFPGQASYASGNAFLDTFADFRRNQGDNIVSFLWTSWNGLGMASSTEYINAELEAKGITSVSRDEAFRAWEHAIKHDIHQAVVLRALPVEENGIPPLPILDEIAPRKRAESSGTEAVSKGEVSEKAPVPKSGPELKEYLQNAISECVAKTLRLPSAADVDPSTALTEMGMDSVMTVSLRKHLQTSLKVTVPPTLIWGHPTVNHLVKWFEEKI
What is the function of this protein?
6-methylsalicylic acid synthase; part of the gene cluster that mediates the biosynthesis of sesquiterpenyl epoxy-cyclohexenoids (SECs) such as anthrobotrisins and arthrosporols, metabolites that possess a novel hybrid carbon skeleton consisting of a polyketide-derived epoxycyclohexenol combined with a terpenoid-derived monocyclic sesquiterpenol substructure (PKS-PTS hybrid) (PubMed:26422178, PubMed:27723963, PubMed:33823587).  The SEC pathway plays an important role for fungal soil colonization via decreasing fungal nematode-capturing ability (PubMed:33823587).  Within the pathway, the polyketide synthase (PKS) AOL_s00215g283 catalyzes the biosynthesis of 6-methylsalicylic acid (6-MSA) via condensation of 1 acetate and 3 malonate units (PubMed:26422178, PubMed:27723963, PubMed:33823587).  AOL_s00215g283 performs a series of programmed reactions including Claisen condensation, dehydration, reduction, and cyclization to yield 6-MSA (PubMed:26422178, PubMed:33823587).  The pathway begins with the biosynthesis of 6-methylsalicylic acid (6-MSA), the first precursor of the polyketide-derived epoxycyclohexenol in arthrosporols, by the polyketide synthase (PKS) AOL_s00215g283.  The 6-methylsalicylic acid decarboxylase AOL_s00215g281 then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol.  The cytochrome P450 monooxygenase AOL_s00215g282 further oxidizes m-cresol to yield toluquinol.  With the assistance of the oxidoreductase AOL_s00215g277, the polyprenyl transferase AOL_s00215g276 catalyzes the farnesylation of toluquinol to produce farnesyl hydroquinone, the hybrid precursor for biosynthesis of SECs.  Farnesyl hydroquinone undergoes epoxidation and then subsequent dehydrogenation to form farnesyl epoxy-quinone, the first and simplest SEC.  The cytochrome P450 monooxygenase AOL_s00215g278 and the FAD-dependent monooxygenase AOL_s00215g279 might be involved in the oxygenation of the phenol moiety, most likely in the epoxy formation.  The cytochrome P450 monooxygenases AOL_s00215g274 and AOL_s00215g280 are involved in specific regional ketone reductions at respectively C-4 and C-1 of farnesyl epoxy-quinone PubMed:33823587 (Probable).
What are the official names of this protein?
6-methylsalicylic acid synthase AOL_s00215g283, 6-MSAS, Sesquiterpenyl epoxy-cyclohexenoids cluster protein AOL_s00215g283, SECs cluster protein AOL_s00215g283.