PharMolix/UniProtQA huggingface dataset:
Protein: RL21_BORBU
Sequence: MYALVEINGKQYKAIEGEFLKIDKISPVEKDKLEFNSVLLINKDGEVKIGKPYVVNSLIRCTYKEDKKDKKVVSYRYRRRKSSERKVGHRQTYSYILVDEIVF
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: GPMI_PSEE4
Sequence: MTSTPKPLVLIILDGFGHSESPEYNAIFAANTPVYDRLRATQPHGLISGSGMDVGLPDGQMGNSEVGHMNLGAGRVVYQDFTRVTKAIRDGEFFENPVLTGAVDKAASAGKAVHILGLLSDGGVHSHQDHLIAMAELAAQRGAEKIYLHAFLDGRDTPPRSAQSSIELLDATFAKLGKGRIASLIGRYYAMDRDNRWDRVSAAYNLIVDSAAEYTADSALAGLQAAYAREENDEFVKATRIGEAVKVEDGDAVIFMNFRADRARELSRAFVEPDFNEFPRARLPKLAAYIGLTQYSAKIPAPAAFAPSSLDNVLGEYLAKNGKTQLRIAETEKYAHVTFFFSGGREEPFEGEERILIPSPKVATYDLQPEMNAPEVTDRIVEAIEQQRFDVIVVNYANGDMVGHTGVFEAAVKAVEALDSCVGRIVEALGKVGGEALITADHGNVEQMEDECTGQAHTAHTSEPVPFIYVGKRKVTVREGGVLADVAPTMLKLLGLEKPAEMTGTSILVDA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: QUEF_AQUAE
Sequence: MEAKEKKYGEIEIEKAQLEAWPNPNPERDYMIEITFPEFTCLCPRSGYPDFATIKIRYIPDKYIVELKSLKLWLNKFRNRYISHEAATNEIYQALYDLLKPRFLEVVGDFHPRGNVHTVVRVRSDENYG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_CUTAK
Sequence: MSRIGRLPIAVPSGVEVKLDGQYVEVKGPKGTLNFTVREPITVSKNDEGAILVERPDDERENRSLHGLTRTLINNMVIGVTEGYEKKLEIQGVGYRVLSKGPKQLEFNLGFSHPVIVDAPEGITFAVENPTKFSVQGIDKQVVGETAANIRKIRKPEPYKGKGVRYEGENVRRKVGKAGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RS19_ANAMM
Sequence: MSRSIKKPPFCAPHVLRLANRAIASNRNAIINIHSRSSVILHKFIGLTFGVHNGRTYVPVKVTDNIVGRKFGEFSPTRRFLGHAGDKKVSRKG
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: MTNN_GEOKA
Sequence: MKAAIIGAMEEEVAILRSRMEGCEETVIAGCEFSKGRLDGVEAVLLKSGIGKVNAAMGTTLLLDHFRPDFVINTGSAGGFLPSLRVGDLVISEEVVHHDVDVTAFGYAYGQVPGLPARYRADEALVEAAKQAAARLDGLQAVTGLIATGDSFMNDPKRVEFVRGQFPELCAVEMEAAAIAQVCVQFGTPFVIIRALSDIAGEESGVSFEQFLETAAKHSAELVLSMLSVMKQKRY
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: YHEU_ECOLC
Sequence: MLIPWQDLSPETLENLIESFVLREGTDYGEHERTLEQKVADVKRQLQCGEAVLVWSELHETVNIMPRSQFRE
What are the official names of this protein?
UPF0270 protein YheU.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: SODF_TETPY
Sequence: LNYEYSDLEPVLSAHLLSFHHGKHHQAYVNNLNATYEQIAAATKENDAHKIATLQSALRFNLGGHVNHWIYWDNLAPVKSGGGVLPDEHSPLTKAIKEKWGSYENFITLFNTRTAAIQGSGWGWLGYDTVSKSLRLFELGNQDMPEWSSIVPLLTIDVWEHAYYLDYQNLRPKYLTEVWKIVNWREVEKRYLQAIE
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Fe].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: DPO4_SALCH
Sequence: MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRERRGVISTANYPARQFGVRSAMPTAMALKLCPHLTLLPGRFVAYKEASRHVRDIFSRYTSLIEPLSLDEAWLDVTDSPHCYGSATLIAREIRQTIFNELQLTASAGVAPVKFLAKIASDLNKPNGQYVITPADVPGFLKTLPLAKIPGVGKVSAAKLENMGLRTCGDIQQCDLAMLLKRFGKFGRVLWERSQGIDERDVNSERLRKSVGVERTLAEDIHEWSDCEAIIEHLYPELERRLAIVKPDLLIARQGVKLKFNDFQQTTQEHVWPQLNKEDLIITARKTWNERRGERGVRLVGLHVTLLDPQLERQLVLGL
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMPG1_CHICK
Sequence: MHLKTGLIFLAICLALQVQGSREIPSKTNHGEAKQLADASGSDKTERTTKRSRVSTIRRIFDMAKHRTKRSPFFSTGVKICPQESVKQILASHQAYYRLRVCQEAVWEAFRIFLDRIPDTSEYQNWVTACQRETFCIFDIGKNFSNSQEHLEIIQRRVKHRTFQERKDEISTDKTGGKKLEDIPSVSTGPPSASLSTYTLVPNGTLLNEIVNETKTPVKELGTNTVPELPAEQMVEFSVTLTDQEYTAELSDPNSPQYRQLAAKFQLQMQKIFEKLPGFKEIHVLGFKQKKEKDGSSSTIARYMVNFERDGSEIKSTADDISTIGSNKVENEKVPLSAKEEREISATKLTVTDLQQLVATALHEDRSLPVDLGTLRFTDEPIKPSSDFDNDIQGMVTIPLAGPDLDDTISAELPLVYPSPITVDQTRDIFVDEFTTGITDLSREIGGPEDFDSNFITSEPAFPTKPSREPPHDRSPDTEDITTDYQRFTVPFSALVSTDSPAKPEDSYLPPPADESDSNDLITDESPTEQVITPAVYTTGSFTLPTFLQATDKDTEAEMKKELVGVTEPLFKEADRDSLSGQAVKMMDELESSGDDILVTTSTYKTLPFLIGSSDLFATQPEVTFAAALPPDQTLLPTVTSPFYSHSVVIDQSPEVPDTLMPAAASALPDRASTGVQDIAAELDGAGVKSTAVLDEAEHGSGYISVQTTEPAEVTQAPTLKYVTTSSMTTAAKGKELVVFFSLRVTNMHFSDDLFNRSSQEYKALEQQFMQLLLPYLQSNLTGFKQLEILNFRNGSVIVNSKMKFARTVPYNITEAVHCVLEDFCDAAAQHLNLEIDSYSLDIEPADQADPCKFMACDEFSKCIMNEWTKEADCLCKPGYASQDGLPCRSLCEMEPHLCDNGGKCELVPGRGAVCRSPDQFTEPGLTS
What is the function of this protein?
Chondroitin sulfate-, heparin- and hyaluronan-binding protein (PubMed:11991949, PubMed:18466325, PubMed:18786170).  May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity).
What are the official names of this protein?
Interphotoreceptor matrix proteoglycan 1, Sialoprotein associated with cones and rods, SPACR.
What are the subcellular locations of this protein?
Cell projection, cilium, photoreceptor outer segment. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Photoreceptor inner segment.
Protein: BOPE_BURTA
Sequence: MTYNPRIGGFTHVKQASFDVHVKRSEARPRTSFAQQIKRIFSKIGETLGQLFRHRAPDGAPGRVKLQGVRYVGSYRPTGDARQAIRHFVDEAVKQVAHARTPEIRQDAEFGRQVYEATLCAIFSEAKDRFCMDPATRAGNVRPAFIAALGDAARATGLPGADKQGVFTPSGAGTNPLYTEIRLRADTLMGAELAARPEYRELQSYARQQAIDLVANALPGERSNTLAEFRQTVQTLEATYRRAAQDASRDEKGAANAADGA
What is the function of this protein?
Activator for both CDC42 and RAC1 by directly interacting with these Rho GTPases and acting as a guanine nucleotide exchange factor (GEF).  This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, thus promoting bacterial entry into non-phagocytic cells (By similarity).
What are the official names of this protein?
Guanine nucleotide exchange factor BopE, Effector protein BopE.
What is the protein family that this protein belongs to?
Belongs to the GEF (guanine exchange factor) SopE family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the bsa type III secretion system.
Protein: GMHBB_PSEAE
Sequence: MSRSLLILDRDGVINLDSDDYIKTLDEWIPIPSSIEAIARLSQAGWTVAVATNQSGIARGYYDLAVLEAMHARLRELVAEQGGEVGLIVYCPHGPDDGCDCRKPKPGMLRQIGEHYGVDLSGIWFVGDSIGDLEAARAVDCQPVLVKTGKGVRTLGKPLPEGTLIFDDLAAVASALLQ
What is the function of this protein?
Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
What are the official names of this protein?
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase, D,D-heptose 1,7-bisphosphate phosphatase, HBP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the GmhB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTCA_BOVIN
Sequence: MAGPRVEVDGGIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIKGGVHTADTKTAGSVCLLMQVSMPCVLFAACPSELRLKGGTNAEMAPQIDYTAMVFKPIVEKFGFTFNCDIKMRGYYPKGGGEVIVRMSPVKQLSPINLTDRGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGAVDEYLQDQLIIFMALASGISRIKTGPVTLHTQTAIHFAEQLAKAKFTVKKSEDEEDASKDTYIIECQGIGMTNPNL
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase, RNA terminal phosphate cyclase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: UBIC_SHELP
Sequence: MSVTRLSFPYGESIQWHSPDQIPQLPPSPFREWLLASGSLTQKLKSHCNQFEVKVLGEAMLPPFPGELPHQGQAWIREVLLCLDGIPWVFARTLVPGAMMDSAQDNFLSLGTRPLGELLFTSGDFTPGKIEVGEFTACDSLAKLIDSLEQESHHPLWGRRRYFSHGDQQLIVSEIFLPKARQLIDRLA
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_BURO0
Sequence: MKPTVWHHLRLCPHGHPDETIDDAAIAVDETGTIAWLGALSALPHGYAHWQREDLHGAWVTPGLVDCHTHLVYGGTRADEFAQRLAGVSYEEIARQGGGIVSTVRATRAADETTLFVQAAARLQPLLAEGVTAIEIKSGYGLDLASERKMLRVARQLGERFPVTVYTTFLGAHALPPEYAGRADEYIEEVCDRMLPTLADEGLVDAVDVFCERIGFSLAQTERVFEAATRRGLPVKLHAEQLSNAGGTALAARYRALSADHLEFLDEAGIEAMKAAGTVAVLLPGAYYFIRETQLPPIELLRKHGVPIALATDHNPGTSPLESLLLTLNMGCTLFRMTVPEVLQGVTRHAAAALGRADRHGALEVGRQADFAAWSVGSLAELAYWIGRPLCEQVVRGGTTVFRRMNG
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
Protein: RDGC_ACTSZ
Sequence: MYWFKNAMIYRLTKKLDWSEEALQQNLTQNAYHPCGQSDMSRFGWSTPLRGAELLHFSVGKQILLVAHKEEKIIPSHVVKRELDNRIDELEQKENRKLKKTEKQALKDDVVSVLLPRAFSKNQQTAIWINTETNLIYIDAASSKRAEDVLALLRKSLGSLPVVPLAFANEPALMMTNWIARNEMPQYLTALEEAELKAADDKGIIRCKNQPLDSEEILSHLEKGKFITKLALDWETHLSFVLNDDGTLKRLKFADNIREKNDDILKEDYAQRFDADFILMTGELTALTENLLDDLGGEKTRL
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SYN_BUCBP
Sequence: MKTVSIFDIYLNKIKLNSKINIQGWVRNRRRSKLGLLFIDLYDGSCLYTMQVVVKDILSNYDSEISKLSVGCSINVFGVLISSIGTKQKYEIQAKVVKVIGIINNPGSYPISSKYHTMKHLRNVPHLRSRTNFFGAVSRVRNYLFNALHEFLFKNGYYWIPSPIITGLNSEGAGDMFKVSILDLNNIPKNKNGKINFKKDFFGKEAFLTVSGQLTLETYACSLSKVYSFGPIFRAENSNTRRHLSEFWMLEVETAFSNLCDIIKFSENMLKYAIGIILDKCVIDINFFRENVDEKIFCRLKDFSSKQFFQIEYKEAINILIKSNRFDHKVMFIGMELSSDHERFLVEEYFKFPLVITNYPKSLKAFYMRVNDDNKTVSAMDVLVPGVGEIIGGSEREERLNVLDRRFFELNLNKEDYWWYRDLRKYGTIPHSGFGLGFERLLSYILGIKNIRDVCPFPRTAYKADF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCSB_ECOLX
Sequence: MNNMNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDKYGDGITLIKYIKRHFPSLSIIVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKISAGGYGDKRLSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNYLSSVTLSPADKD
What is the function of this protein?
Component of the Rcs signaling system, which controls transcription of numerous genes.  RcsB is the response regulator that binds to regulatory DNA regions.  Can function both in an RcsA-dependent or RcsA-independent manner (By similarity).  Involved in regulation of K30 capsular polysaccharide synthesis.
What are the official names of this protein?
Transcriptional regulatory protein RcsB.
What is the protein family that this protein belongs to?
Belongs to the RcsB family.
Protein: TOP6B_THESM
Sequence: MANSEADKLFKEFKIQSVSEFFRRNAAMLGYTGKLRSLTTLIHEAVTNSLDACEEAGILPYVRVEIEELGTEHYKIIVEDNGPGIPEKFIAHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRIITSTGEEEIIEAWVGIDVDKNEGKIFKKIKHPNPTGWRGTRIEMEVKDVRYIRSKQGVYWYLKLTAIANPHAHIEFIEPDGKLIVFSRSSEELPEPPEEMKPHPKGIITDDIYRMAQRTTRTTVRTFLIGEFSRISDKKIDELVQYITALRLIKEEEEQNVKEQLMKRLVDGEVDKIIASFGKRGKKVLREVRKIMEKPPKKLTWHEAEEIVEAFKYMTFLAPPTHGLRPIGEENIEKGLTGILRPEFVTSVTRPPKVYRGGIPFQVEVGLAFGGELSSGFDLLRYANRVPLLFDAGSCVITSAARNIDWKRYRVDDVDRAPLALLVNVVSVHVPYTSTGKQSVANEEEIYEEIRLAVMDVARRLAKYLGGKHRKLYQVKRRKTLEKYVPEVSRALSILTGLPEGEIKKMLVTIIEKKFESIDEAVEAESDA
What is the function of this protein?
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit B, Type II DNA topoisomerase VI subunit B, TopoVI-B.
What is the protein family that this protein belongs to?
Belongs to the TOP6B family.
Protein: RNH2_ORITB
Sequence: MNPNLNIEQDNASEIVAGVDEAGRGPLAGPVVAAAVVVNQSIMIDDIKDSKVLSKSKRESCYDKITNSYYYSIGIASVQEIDKYNILEATKLACIRAVKNLAIIPTKVLVDGNMNFTDNRFISIVRGDQICYSISSASIVAKVTRDRIMQILHKEYPVYGWNQNCGYGTKLHIDAIKTYGQTIHHRVSFKFKGNINHSAILGNMV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRVP_HEMHA
Sequence: SVDFNSESTRREEKQKEIVDLHNXLRDXVX
What is the function of this protein?
Inhibits calcium-activated potassium channels (KCa), voltage-gated potassium channel (Kv), and the calcium release channel/ryanodine receptor (RyR).
What are the official names of this protein?
Cysteine-rich venom protein hematin, CRVP.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: GALT2_HUMAN
Sequence: MRRRSRMLLCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLNLQQ
What is the function of this protein?
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.  Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b.  Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.  Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP.  It participates in the regulation of HDL-C metabolism (PubMed:27508872, PubMed:32293671).
What are the official names of this protein?
Polypeptide N-acetylgalactosaminyltransferase 2, Polypeptide GalNAc transferase 2, GalNAc-T2, pp-GaNTase 2, Protein-UDP acetylgalactosaminyltransferase 2, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
Protein: SUMF2_MOUSE
Sequence: MRSEFWFPSMGSLLPPVLLLWLLSCPRLQLGHAQDPAMVHLPGGRFLMGTDAPDGRDGEGPAREVTVKPFAIDIFPVTNKDFREFVREKKYQTEAEAFGWSFVFEDFVSPELRKQENLMPAVHWWQPVPKAFWRQPAGPGSGIREKLELPVVHVSWNDAGAYCAWRGRRLPTEEEWEFAARGGLKGQVYPWGNRFQPNRTNLWQGKFPKGDKAEDGFHGLSPVNAFPPQNNYGLYDLMGNVWEWTASTYQPAGQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCASSAGRPKEDL
What is the function of this protein?
Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form.  Inhibits the activation of sulfatases by SUMF1.
What are the official names of this protein?
Inactive C-alpha-formylglycine-generating enzyme 2, Sulfatase-modifying factor 2.
What is the protein family that this protein belongs to?
Belongs to the sulfatase-modifying factor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: PSAI_MARPO
Sequence: MTASYLPSIFVPLVGLIFPAITMASLFIYIEQDEIL
What is the function of this protein?
May help in the organization of the PsaL subunit.
What are the official names of this protein?
Photosystem I reaction center subunit VIII, PSI-I.
What is the protein family that this protein belongs to?
Belongs to the PsaI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CH60_EHRCJ
Sequence: MANVVVTGEQLDKAIREVVHILEDAVGCTAGPKGLTVAISKPYGAPEITKDGYKVIKSIKPEDPLALAIANIIAQSASQCNDKVGDGTTTCSILTAKVIEEVSKAKAAGADIVCIKDGVLKAKEAVLDALMSMKREVLSEEEIAQVATISANGDKNIGVKIAQCVQEVGKDGVITVEESKGFKELDVEKTDGMQFDRGYLSPYFVTNSEKMLVEFENPYILLTEKKLNIIQPILPILENVARSGRPLLIIAEDVEGEALSTLVLNKLRGGLHVAAVKAPGFGDRRKDMLGDIAILTGAKHVISDDLAIKMEDLTLAELGTAKNIRITKDTTTIIGSVDNSSDNVQSRINQIKVQIESSTSDYDKEKLRERLAKLSGGVAVLKVGGSSEVEVKERKDRVEDALHATRAAVEEGVVPGGGAALLYTLSVLENLKSKNDDEQLGINIIKRALQAPIKRIIRNSGSENAPCVIAHLLKQNDKELIFNVDTMNFANAFTSGVIDPLKVVRIAFDFAVSLAAVFMTLNAIVVDVPSKDDAGAAGGAGGMGGMGGMGGF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_STUS1
Sequence: MEVILLEKIANLGNLGDKVNVKAGYGRNYLLPQGKATAATPANIAEFEARRAELEKAAAEKKASAETRAAQLAELEVTITATAGDEGKLFGSIGTADIADALTASGVEVAKSEVRLPNGTIRQTGEYDVAVHLHTDVEATVKLIVVAG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: LPXC_BURO0
Sequence: MLKQRTIKSIVKTVGIGVHSGRKIELTLRPAAPGTGIVFSRVDLPTPVDIPASAMSIGDTRLASVLQKDGVRVSTVEHLMSACAGLGIDNLYVDVTAEEIPIMDGSAATFVFLIQSAGIEEQNAPKRFIKVTKPVEIRDGDKFARLDPYFGFKLKFSIDFRHPAVDKTGQELEVDFATTSYVREIARARTFGFAHEAEMLREIGLARGGSMDNAIVLDEYRILNNDGLRYDDEFVKHKMLDAIGDLYVIGHPLLASYTAYKSGHGLNNALLRELLAHEDAYEIVTFDDPQAAPKGFAFDAQTAFA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: NUSB_SALEP
Sequence: MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLSGVATNSAYLDGLMKPYLSRLLEELGQVEKAVLRIALFELSKRSDVPYKVAINEAIELAKTFGAEDSHKFVNGVLDKAAPVIRPNKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: AROB_FRATW
Sequence: MISKLSVNPTFSPSYNIIVDSVLDFSHILEYVTNKQVLVVTNTTVAKLYLTKFLAALVDDLDVRTCILEDGEQYKSQQSLDKILSTLLENHFTRNSTVLVALGGGVIGDITGFAAAIYQRGIDFIQIPTTLLSQVDSSVGGKTAINHQLGKNMIGAFYQPKVVYTSIEFYKTLSQREYIAGMAEVVKYAFISKDFYLWLDSNRDKILAKDSVTLIEMVKRSCQIKAQVVAMDEKELTGARAILNFGHTFGHAIEKCQNYRGLKHGEAVGVGMAQAIDFSHYLGLISQQQAKDFNDFIVSFGISIDFPNDICQKEFLEAMLLDKKNSNKELKFILIENIGSLSLQKQSKNELEQFLDISR
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.