PharMolix/UniProtQA huggingface dataset:
Protein: CYB_GENJO
Sequence: MTDIRKSHPLAKIINESFIDLPAPSNISAWWNFGSLLGVCLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHAGRGVYYGSYTFTETWNIGILLMFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRLFAFHFILPFIISALAAVHLLFLHETGSNNPSGMMSDSDKIPFHPYYTIKDILGILLLILVLMLLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAIIPFLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFITIGQLASILYFSIFLILMPVSGIIENRLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NLT13_PARJU
Sequence: MRTVSARSSVALVVIVAAVLVWTSSASVAPAPAPGSEETCGTVVGALMPCLPFVQGKEKEPSKGCCSGAKRLDGETKTGPQRVHACECIQTAMKTYSDIDGKLVSEVPKHCGIVDSKLPPIDVNMDCKTLGVLHYKGN
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
What are the official names of this protein?
Probable non-specific lipid-transfer protein 1, LTP, Allergen Par j I, Major pollen allergen Par j 1.0201, Protein P1.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: MNMA_NATTJ
Sequence: MMMSNRVLVAMSGGVDSSVAALMLKEQGYEVIGAHMRIWYREEDEELYEQNVKGCCSLAAVHDAKRVADKIGIPFYVLNFKEPFYDWVVKNFIDEYLQGRTPNPCIACNRFIKWEEFLKRAMALECDYIATGHYSKIVYDNLKNRYLLYRGKDKTKDQSYMLSQLTQEQLARTLFPLGDYYKEDVRNIAEQNELGVADKPDSQEICFVPNNDYGEFLQSVVPEHINPGPILDAQGNKLGEHKGIAFYTIGQRRGLGISLGRPVYVIDIDADNNALIVGDKEELYSDGLIAEEINLIPYEQIENSIDIECKIRYNSRNVSSTLQPYGNDQLLVKFNQPVEAVTPGQGVTFYQDDLVIGGGTILKATTKK
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTQA_ECOL6
Sequence: MMDLDNIPDTQTEAEELEEVVMGLIINSGQARSLAYAALKQAKQGDFAAAKAMMDQSRMALNEAHLVQTKLIEGDAGEGKMKVSLVLVHAQDHLMTSMLARELITELIELHEKLKA
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2).
What are the official names of this protein?
PTS system N,N'-diacetylchitobiose-specific EIIA component, EIIA-Chb, EIII-Chb, IIIcel, N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_THEPX
Sequence: MRLAIDAMGGDHAPEEIIKGSLEALKHFHDIEIVLIGKEEVLRGLQGKEKRLKLVYASEVIENDEVPVTAVRKKKDSSMIVGLELLKKEEVDAFLSAGNTGALMAGALLTLGRIKGIDRPALAPILPTLNGATVLLDAGSNTNCDAQNLVQFAAMGHVYAQKMFGIERPRVGLFNIGVEEEKGNEVVKKAFEELKKSKLNFIGNVEGRDIPYGVCEVVVCDGFVGNAILKSMEGIASVISQLLKEELTRNIFTKLGALLIMGGLKRITKKMDYTEYGGAPLLGIKKPVIKAHGNSKAKAIFNAIKQAKNFVDNDVLNHIKEEIESMGDELSV
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: Y4MI_SINFN
Sequence: MRKKLNGWLAMAAGAALAALSSVSHAEDRKTVAYLAPSLDISYWQWVGFGVKQKAQELGMDYVEFTSENSPAKQMDNARTAVTKGVDAIVIGPVSSTSTPPLLAYLKSQNIPIAFAGIGPQPGQTDYTSSVTANNYETGKAQGSFVCALAKERGGNKVGMLSLPQDRENAQKYLKGAQEAFAADGCELVQMLETRGLTVNEAVTQANDMLTAHPDIKAIYGMYDEAGTGAAKVLETRGLTGKIGIAVADGSPTTIALLKATAIQGIFFQEAVGQGIDGTLQVFNALTNAPVEKDLALVMPLVTADKIDTAEAKAVIARVFPPSN
What is the function of this protein?
Probably part of the binding-protein-dependent transport system y4mIJK.  This system probably transports a sugar.
What are the official names of this protein?
Probable ABC transporter periplasmic-binding protein y4mI.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 2 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DTD_LEGPL
Sequence: MLTVLQRVKEARVDIDGQTVGKINHGLLILCGFEPNDSLENIKRMLDKCINYRIFEDPSGKMNLSLKDVNGGLLLVPQFTLMADTQKGLRPSFSNAASPELGRELFDNLLTLAQKCHQNTQSGCFGANMQVYLCNDGPVTFLLQF
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_RICBR
Sequence: MKKNPKILLIGSGNIGGTLAHLISLKNLGDIVLFDVAEGIPQGKALDIMQANTLAGSDIKIKGTNDYKDIEGSDAIIITAGLPRKPGMSRDDLISVNTGIMKSVAENVKKYAPNAFVIVITNPLDVMVYVMLKESGLPHNKVIGMAGVLDSSRFNFFLAEEFKVSTNSVSSIVLGGHGDAMVPLARYSTVKGVPIPDLVKMGLSTNERIEKIIDRTRNGGGEIVALLKTGSAYYAPAASAVEMLESYLQDKRQILTCAAYLQGEYGVKDLYAGVPIIIGKNGVEKVIELQLTTNEQALFDKSVDGVRKLIEAVK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: DUT_NEIM0
Sequence: MNIEVEMKVLDERMADFIPAYATEGSAGLDLRACLDEEVVLQPGETFLVPTGLAIYLANPAYAAVLLPRSGLGHKHGIVLGNLVGLIDSDYQGELKVSLWNRGSEPFAVKPFERIAQMVIVPVVQAGFKRVEEFVGSSRGEGGFGSTGSH
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: FER6_USTMA
Sequence: MTPEASANWFSLCWFAWIDPILTAGYTRPMEKDDLYLLQPHRCSEHLGSQLLAALEKRRKQRQDYVEANPNKTDKPAKIPPLMWAMNDIVFRYFWIGGLLKLLADVGTITSPLLVRALINFGRDSYNLRGDRDQAPNLGSGVGLAIGLFLVQALCVFLNVHAFNRGFGTGIILRGALIQAIFQRGMNLSTRARTVGGLGVSKLVTLISADATRIDYAGQFFHMAWTSAVQIIICVALLIWSLSYSALPGIAVLVLMSPIQTAITKRLFALRKKSMVWTDKRNKAVNEVVGGIRVVKQFAWEEPYSVRIAELRRKEMSFHRVRLYLRSLNLALAFATPTIATVLSFVTYALVGNELDAAILFSSLSFFTLLRTPLQFLPIAWNAIVDAKNAADRIEKVFDAEIQRDQIIRDCSATNGIQLEDASFTWETAQAADTAKPVNEKKGQDSPSNEKETPVDRASTLDSLNLTVPRGTLCAIVGGVGSGKSSLISALAGEMRQIAGKVTLSGSTAVCAQTAWIQSTTIRNNIVFGNAFDPERYRYVLEVCCLLPDLDTLADGDQTIVGEKGVSLSGGQKQRLNIARALYHNSEIVLLDDCLSALDARVGADIFANVIAGDAMAGKTRLLVTHSLNVLRSCDWIVHMEEGRITEQGTYAELVESKGRVAELLLTHTKDHFEEEKKEPSKHPIDEIQETAESILDAGSASNRNSEASESTTTTVNAESKDTSNAEGVTNKTEKKDLVAPPAQAKSKALMQDEERFSGSVSRTTYLSYLNAAPLSILLPLFLVAVLVFQGSTIMSPVWLLWWQNGHFGLQQGVYMGIYAVFGITQSLGLLSMGVIFSTFTIKSATTLHHRALQRVLHAPFSFFDTTPQGRITHRFSKDMDTLDNIIGEAMRTLIGTIVQVIGSIVLIAILTPYFLIPVAVILVLYFWIAAYYRSTARELRRIDAGLRSNMHEHFSESLHGLVTIRAFGNVDAFIAENCRRIDKQNRAYWLAQTCQRWLSVRLDFLGSLLILSVAILVVASRFDISPGETGVALSYILTAQSIFGWMIRHAAELENNMSAVERVLHYANHIEQEKPYHIPQVDDALEAREWPERGEIRFEGVEAKYGSSERNVLDKLDLHIAPGEKIAFCGRTGAGKSTLVTTLLRTLELSAGTITIDGIDIASMGLHRLRSSLSLIPQDAVIYSGTLRYNLDPLDQHEDATLHDALQRTSLTDLSLDMTITEEGGNLSAGQRSLISLARAMVRKTRIVILDEATASIDQETDVQIQEVLRNEFDGITTLTVAHRIQTILHSDRVCVLDKGVIVEIGSPAELWAKEKGAFRALCDSANIRYQDGEWK
What is the function of this protein?
Multidrug resistance protein; part of the gene cluster that mediates the biosynthesis of siderophore ferrichrome A which is contributing to organismal virulence (PubMed:17138696, Ref. 4).
What are the official names of this protein?
Multidrug resistance protein fer6, ATP-binding cassette sub-family C member fer6, Fe-regulated protein 6.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SCRK_LACLC
Sequence: MSVYYGSIEAGGTKFVLAIADEHFNIIKKFKFATTTPQETISKTIKYFKENRVSAIGLGSFGPIDLNLSSKTYGYITSTPKVGWKNINLVGQLKEALDIPIYFTTDVNASAYGEMKNTGIKNLVYLTIGTGIGGGAIQNGYFIGGIGHSEMGHQRINRHRDVLTFEGICPFHGDCLEGVAAGPSLEARTGILGEKISSDDPIWDILSYYIAQAAINATLTLAPECIILGGGVMEKPNMISLIQKQFISMLNNYIDLPCSVEKYIRLPTVKENGSATLGNFYLAYSLFTKE
What are the official names of this protein?
Fructokinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family.
Protein: 116L_IIV6
Sequence: MNQNPLTSEQLNNAYFNLLTPQQKQMVADFGKNMYSDFTKYEAPKTTTSTPLNDEEEIEWLVRQIMSGLQLCDINAKGKKLLQKKYGKTWKSKLF
What are the official names of this protein?
Uncharacterized protein 116L.
Protein: BID_MOUSE
Sequence: MDSEVSNGSGLGAEHITDLLVFGFLQSSGCTRQELEVLGRELPVQAYWEADLEDELQTDGSQASRSFNQGRIEPDSESQEEIIHNIARHLAQIGDEMDHNIQPTLVRQLAAQFMNGSLSEEDKRNCLAKALDEVKTAFPRDMENDKAMLIMTMLLAKKVASHAPSLLRDVFHTTVNFINQNLFSYVRNLVRNEMD
What is the function of this protein?
Induces caspase activation and apoptosis (By similarity).  Allows the release of cytochrome c (PubMed:9873064).
What are the official names of this protein?
BH3-interacting domain death agonist, p22 BID, BID.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion membrane. Mitochondrion outer membrane. Note=When uncleaved, it is predominantly cytoplasmic. SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p15]: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p13]: Mitochondrion membrane. Note=Associated with the mitochondrial membrane.
Protein: UPPP_ALBFT
Sequence: MDIVLLIKAAIMGLVEGLTEFLPISSTGHLILAGTLLGFDNEVGKVFDIAIQTGAIFAVILVYWQKIRDTLVALPTEKQAQRFSLNVLIAFVPAVVLGLLFGKAIKAHLFTPVVVASTFIIGGFIILWAERRQEKNPAAVRIHDVESMTPMDALKVGLAQCLAMIPGTSRSGATIIGGMLLGLSRKAATDFSFYLAIPTLIGAGVYSLFKERALLSMADLPTFAVGLVVSFFSAWLCIRWLLRYIASHSFVGFAYYRIVFGVVVLATAWSGAVTWAA
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUTB_ECOL5
Sequence: MTTLTARPEAITFDPQQSALIVVDMQNAYATPGGYLDLAGFDVSTTRPVIANIQTAVTAARAAGMLIIWFQNGWDEQYVEAGGPGSPNFHKSNALKTMRNQPQLQGKLLAKGSWDYQLVDELMPQPGDIVLPKPRYSGFFNTPLDSILRSRGIRHLVFTGIATNVCVESTLRDGFFLEYFGVVLEDATHQAGPEFAQKAALFNIETFFGWVSDVETFCDALSSTSFARIA
What is the function of this protein?
Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate.  The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.
What are the official names of this protein?
Ureidoacrylate amidohydrolase RutB.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family. RutB subfamily.
Protein: FGD_NOCFA
Sequence: MGDLELGFKASAEQFGPRELVDIAVLAEEHGMDSATVSDHFQPWRHKGGHAPFSLAWMAAVGARTERIKLGTSVLTPTFRYNPAVIAQAFATMGCLYPGRVMLGVGTGEALNEIATGYQGEWPEFKERFARLREAVELMRALWTGDRVDFDGQYYRTVGASIYDVPEGGVPIYIAAGGPLVARYAGRAGDGFICTSGKGMELYTDKLMPAVAEGAAKAGRSVDSIDRMIEIKISYDTDPELALENTRFWAPLSLTAEQKHSITDPIEMEAAADALPIEQIAKRWIVASDPDQAVEQIKPYLDAGLNHLVFHAPGHDQRRFLDLFQRDLAPRLRALA
What is the function of this protein?
Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone.
What are the official names of this protein?
F420-dependent glucose-6-phosphate dehydrogenase, FGD, G6PD.
What is the protein family that this protein belongs to?
Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family.
Protein: GBLP_ORENI
Sequence: MTEQMTVRGTLKGHSGWVTQIATTPKYPDMILSASRDKSIIMWKLTRDETNYGIPQRSLKGHSHFVSDVVISSDGQFALSGAWDGTLRLWDLTTGLTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLGVCKYTIQDEGHTEWVSCVRFSPNSSNPIIVSCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDSGDVINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELRQEVISTNSKAEPPQCTSLAWSADGQTLFAGYTDNLIRVWQVTIGTR
What is the function of this protein?
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules.  Interacts with a wide variety of proteins and plays a role in many cellular processes.  Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta-2-like 1, Receptor of activated protein kinase C, RACK.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUI1_IGNH4
Sequence: MGTLDPSVCGGLPPEVCEQLMMDQQELIKIKLEKRKWGREVTIIEGLNLDNERLKKVAKQLKSKLATGGTVKNGRIELQGDHRDRVKKLLEEMGYPPENIVIVG
What are the official names of this protein?
Protein translation factor SUI1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: HTPX_ACIB5
Sequence: MMRIGLFLLTNLAVLVVAGIILSLFGVGSYHGAGGLNLGNLLVICFVFGMVGSLVSLFMSKWMAKKTTGTELIDPNAPRNQAESWLLQTVAELSQRAGINMPEVGIFPSYQSNAFATGWNKNDALVAVSSGLLERMNKDELRAVLAHEIGHVANGDMVTLALIQGVVNAFVMFFARVVGDFIDRNVFGRQDNEAPGMGYFIITMVLDIVFGILASAIVMWFSRYREYRADEAGARLAGKQAMISALLRLQAETELPDQMPKEMKAFAIAEGKEQGFSLAALFQTHPTIEQRVAALHQLDCP
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYAY_PSEPG
Sequence: MSLSEARFHDLVDATQQALEDLFDESGMDLDMENSAGVLTVKFEGGAQLIFSRQEPLRQLWLADRSGGFHFDYDEESKKWVCEKSEELLGEMLERIVWERAGEKLDFDEI
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: FICD_DROAN
Sequence: MGATDQALEAESKTTEPPKTPPVPEQHDRPFLGRQANLCHLLVLLFSGGLAAITLHIFTSSNVGWRLRQLHHLPTAHYLQTRDEFAVYSVDELNAFKEFYDRSISDSVGSSYSEAEETNIKEALGALRLAQDMYLAGKDDKAARLFQHSLALAPRHPTVLLRYGEFLEHSQRNIVLADQYYFQALSISPSNSEALANRQRTADVVQSLDERRLESLDSKRDALSAIHESSAALRRAKKEAYFQHIYHTVGIEGNTMTLAQTRSILETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKMEITIKDILELHRRVLGHVDPIEGGEFRRNQVYVGGHVPPGPGDLALLMQRFERWLNSEHSSSMHPVNYAALAHYKLVHIHPFIDGNGRTSRLLMNTLLMRAGYPPVIIPKQQRSKYYHFLKLANEGDIRPFVRFIADCTEKTLDLYLWATSDLPHQIPMLIQSTSEAGEGVPQLQSSQMGGGASIPEFHESGSGSLP
What is the function of this protein?
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity).  The side chain of Glu-252 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity).  Acts as a key regulator of the unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of Hsc70-3/BiP.  In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of Hsc70-3/BiP at 'Thr-518', thereby inactivating it.  In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from Hsc70-3/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity).
What are the official names of this protein?
Protein adenylyltransferase Fic, De-AMPylase Fic.
What is the protein family that this protein belongs to?
Belongs to the fic family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: MSHR_NOMCO
Sequence: MAVQGFQRRLLGSLNSTPTAIPQLRLAANQTGARCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPTYCFICCLALSDLLVSGGNVLETVVILLLEASALAARAAVVQQLDNVIDVITCSSMVSSLCFLGAIAVDRHVSIFYALRYHSIVTLPRARQAIAAIWVASVLFSALFIAYCDHAAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIAQLHKRQRPLHQGFGLKGAVTLSILLGIFFLCWGPFFLHLTLIVLCPQHPTCSCIFKNFNLFLTLIICNAIIDPLIYAFRRQELRRTLKEVLTCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS6_CORJK
Sequence: MRQYEMMIIIDPSQDERTVAPSLDKYLDIVRKENGSVEKVDIWGKRRLEYPINKKDEGIYVVLDLKCESATVLEIDRLLNINDQILRTKVLRKDQ
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: GRHL3_XENTR
Sequence: MSNELDYRPVMLLQNDINLKYSSPNDDEAWSKYLENPMTAATKAMMRANGDDDGVAALSLLYDYYRVPKEKRIITQGSTGRCDQVKRSCIEYDSDISTYDSTQLMRFLNDNNSSTHEYSETHKKNSYLSLDCLINPSKLPLSSGKLDNNAHDDFMATSCDVYEKNPLTTLFDPIHVPPPQQRWQPDSTFKEDTPEPLIFNDILRSQAESTCSEDYIPGEANRDFECTLESPKAIHIKSGESPMAYLNKGQFYPVNLRTAETRKCVHLTSNKVKSVVMVVFDNEKNPEEQLKRWKHWHSRQPTAKQRVIDVADYKENCNTVENIEEVAYNALSFVWNINEEAKIFIGINCLSTDFSSQKGVKGVPLNLQIDTYDFETGVKRLIHRAVCQIKIFCDKGAERKMRDEERKQFRRKGKSADQNNKDIKASVLPGYRGSDFTYLRPVTDMETHPVLFIPNIHYSNLQRCGVVLQSAADNSDRLSLKRSSQSFPESFEAPPSKQQTNEDPQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYELPEERICRVYKKCKRGILVNMDNNIIQHYSNHVAFLLDLTDVDGKIQVTLKEL
What is the function of this protein?
Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin.  Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes.
What are the official names of this protein?
Grainyhead-like protein 3 homolog, Transcription factor CP2-like 4.
What is the protein family that this protein belongs to?
Belongs to the grh/CP2 family. Grainyhead subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SFI1_SEGFL
Sequence: KECMTDGTVCYIHNHNDCCGSCLCSNGPIARPWEMMVGNCMCGPKA
What is the function of this protein?
Insecticidal toxin (PubMed:11689233).  It inhibits insect voltage-gated sodium channels (Nav) by partially blocking the channel pore (1 uM inhibits 55. 7% sodium current in DUM neurons from the American cockroach), not by acting as a gating modifier (PubMed:25559770).  The inhibition is only partially reversible (about 25% recovery) after prolonged washout (PubMed:25559770).  In vivo, the toxin causes flaccid paralysis followed by death when injected into Heliothis virescens larvae (PubMed:11689233).  It also causes uncoordinated movements followed by full paralysis to sheep blowflies (Lucilia cuprina) (PubMed:25559770).
What are the official names of this protein?
Mu-segestritoxin-Sf1a, Mu-SGTX-Sf1a, F5.6, Toxin SFI1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 16 (SFI) family.
What are the subcellular locations of this protein?
Secreted.
Protein: COF_SHISS
Sequence: MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: COA3_DROME
Sequence: MSASEQGPKIKYGESAPKLDKAQLQFMKLIEEQNLDRVQKLKRIRRNNLLTAGALGVSVLAIYGYSIFSVQQEKFLDDFEEPKKVSS
What is the function of this protein?
Plays a critical role in the biogenesis and activity of cytochrome c oxidase (COX) (complex IV).
What are the official names of this protein?
Cytochrome c oxidase assembly factor 3, mitochondrial, Coiled-coil domain-containing protein 56 homolog.
What is the protein family that this protein belongs to?
Belongs to the COA3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: TYSY_YERPN
Sequence: MKQYLDLMKKVLEEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLNGDTNIAYLKENNVSIWDEWADENGDLGPIYGKQWRAWGAADGRKIDQLSNVVNQLKQDPDSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWTGGDTHLYSNHIDQAHLQLSREPRVLPKLVIKRKPDSLFDYHFDDFDIEGYDPHPGIKAPIAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_DESAP
Sequence: MGQKVDPRGLRLGIVRDWDAKWYAGKKDFSNLLLEDVKIRDYIKSKLLAAGISRIHIERTANRVRIAIHTAKPGVVIGRGGTEVEVLRKELEKLTGRQISINIVEIKTPELDAQLVAENVAAQLQRRVAFRRAMKQAVGRAMKLGAKGIRISVAGRLAGAEIARTEWYSEGKVPLHTLRADIDYGFSEAKTTYGKIGVKVWIYRGEILPERAAREGGR
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.