PharMolix/UniProtQA huggingface dataset:
Protein: AROC_PROM0
Sequence: MSSSFGKIFRVSTFGESHGGAVGVILDGCPPKLKIDINLIQNELDRRRPGQSDITTPRNEEDKIEILSGIKEGLTLGTPIAMLVRNKDQRPADYNNMEQVFRPSHADGTYHLKYGIQASSGGGRASARETIGRVAAGAVAKQLLKTFCNTEILSWVKRIHDIDSDINKEKISLKKIDSNIVRCPDEKVSTEMIERIKELKRQGDSCGGVIECLVRNVPSGLGMPVFDKLEADLAKALMSLPATKGFEIGSGFSGTYLKGSEHNDSFIKSDDSSKLRTTSNNSGGIQGGISNGENIEMKIAFKPTATIGKEQKTVNAEGKEVLMKAKGRHDPCVLPRAVPMVDAMVALVLADHLLLNHAQCDLINN
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PPR80_ARATH
Sequence: MVMRPISNKGLIYRHNICLRCNSTLAVSNHEPITQKTRNFLETTTTSTAIFQCNSQISKHARNGNLQEAEAIFRQMSNRSIVSWIAMISAYAENGKMSKAWQVFDEMPVRVTTSYNAMITAMIKNKCDLGKAYELFCDIPEKNAVSYATMITGFVRAGRFDEAEFLYAETPVKFRDSVASNVLLSGYLRAGKWNEAVRVFQGMAVKEVVSCSSMVHGYCKMGRIVDARSLFDRMTERNVITWTAMIDGYFKAGFFEDGFGLFLRMRQEGDVKVNSNTLAVMFKACRDFVRYREGSQIHGLVSRMPLEFDLFLGNSLMSMYSKLGYMGEAKAVFGVMKNKDSVSWNSLITGLVQRKQISEAYELFEKMPGKDMVSWTDMIKGFSGKGEISKCVELFGMMPEKDNITWTAMISAFVSNGYYEEALCWFHKMLQKEVCPNSYTFSSVLSATASLADLIEGLQIHGRVVKMNIVNDLSVQNSLVSMYCKCGNTNDAYKIFSCISEPNIVSYNTMISGYSYNGFGKKALKLFSMLESSGKEPNGVTFLALLSACVHVGYVDLGWKYFKSMKSSYNIEPGPDHYACMVDLLGRSGLLDDASNLISTMPCKPHSGVWGSLLSASKTHLRVDLAELAAKKLIELEPDSATPYVVLSQLYSIIGKNRDCDRIMNIKKSKRIKKDPGSSWIILKGEVHNFLAGDESQLNLEEIGFTLKMIRKEMELI
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g53600, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HTPX_MANSM
Sequence: MMRILLFLATNAAVLIVFNIILSLTGIRGQDAMGLLIMAALFGFTGSIISLLMSKRSALAATGAEVIEQPRNDTERWLLQTVHSQAEKAGLPKPDVAIYHSNDVNAFATGASKNNSLVAVSTALLNNMTRDEAEGVLAHEISHIKNGDMVTMTLLQGVLNTFVIFAARMIARMVANNRSSEESNSGIYFLVAMVLEVVFGFLASMIAMWFSRFREFRADAGSAELAGKQKMIAALKRLQAIHEPQEMDGKLAAFAINGKRGGFTSLFLSHPPLEKRIEALETSK
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DPO3B_MYCPA
Sequence: MDAATTTAGLSDLKFRLVRESFADAVSWVAKSLPSRPAVPVLSGVLLSGTDEGLTISGFDYEVSAEAQVAAEIASPGSVLVSGRLLSDIVRALPNKPIDFYVDGNRVALNCGSARFSLPTMAVEDYPTLPTLPEETGTLPADLFAEAIGQVAIAAGRDDTLPMLTGIRVEISGDTVVLAATDRFRLAVRELTWSAASPDIEAAVLVPAKTLAEAARTGIDGSDVRLSLGAGAGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPAEHTAVATINVAELTEAIKLVALVADRGAQVRMEFSEGSLRLSAGADDVGRAEEDLAVDFAGEPLTIAFNPTYLTDGLGSVRSERVSFGFTTPGKPALLRPASDDDSPPSGSGPFSALPTDYVYLLMPVRLPG
What is the function of this protein?
Confers DNA tethering and processivity to DNA polymerases and other proteins.  Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA.  Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity.  The beta chain is required for initiation of replication as well as for processivity of DNA replication.
What are the official names of this protein?
Beta sliding clamp, Beta clamp, Sliding clamp, Beta-clamp processivity factor, DNA polymerase III beta sliding clamp subunit, DNA polymerase III subunit beta.
What is the protein family that this protein belongs to?
Belongs to the beta sliding clamp family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y856_MIMIV
Sequence: MEIINACLKNVGVEENMIEKVIETFQKENDECYNLVHIFNKAAIVFHRNGQHKKSLEMYEKAFGNIFNGEFALSDLFYSVNGMASMYQALGDYDIAIKKYNSVIKIIKDMCLDNNSDLVYALMGIASISQIKGNYDEALSKYNEALEINEKLYGRNHIETAFVLNRLGMLYHELDDNDKSIDHFNESLKIYREKYPNKLFNIAFTISRLAQSLLKMGNDSEALEKYQESIDIFNKIFTISHQAVAFSLYGIGTVYEFRSEYSKALEKYQESLQTYKNVYERSEKYQHYDIASCLYKIGLVYKLSGNDNESTTYLNQANQMFESTSTNINDKNYQACKKFLQD
What are the official names of this protein?
Putative TPR repeat-containing protein R856.
Protein: WZYE_SALDC
Sequence: MSLMQFSGLLVVWLLSTLFIATLTWFEFRRVRFNFNVFFSLLFLLTFFFGFPLTSVLVFRFDVGVAPPEILLQALLSAACFYGVYYVTYKTRLRKRVVDVPRKPLFTMNRVETHLTWVILMGIALVSVAIFFMHNGFLLFRLHSYSQIFSSEVSGVALKRFFYFFIPAMLVVYFLRQDSKAWLFFLVSTVAFGLLTYMIVGGTRANIIIAFAIFLFIGIIRGWISLWMLAAAGVLGIVGMFWLALKRYGLNVSGDEAFYTFLYLTRDTFSPWENLALLLQNYHNIDFQGLAPIVRDFYVFIPTWLWPGRPSIVLNSANYFTWEVLNNHSGLAISPTLIGSLVVMGGALFIPLGAIVVGLIIKWFDWLYELGNREPNRYKAAILHSFCFGAIFNMIVLAREGLDSFVSRVVFFLVVFGASLLVAKLLFWLFDSAGLIHKRTTSLPQAQVEGKL
What is the function of this protein?
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
What are the official names of this protein?
Probable ECA polymerase.
What is the protein family that this protein belongs to?
Belongs to the WzyE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SCPA_BACCQ
Sequence: MQYNFKVEAFEGPLDLLLHLIHRYEIDIYNIPVAEITEQYLSYVHTMKELQLDVASEYLVMAATLLQIKSKMLLPKHEEDVLDNGDDFIDDPRQELMERLIEYKKYKQVATELKEREQERAQLYTRPPIDFTSLQQEEETSLPLDVTLYDMLAAFQKLMRRKKAKKPVTTRITRQEIPIEQRMTDILKLLEIQGGRQSFYDLFVDDEREIMVVTFLAVLELMKNQQIVIEQEHNFDEIFVSSYTKSA
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: CXCR3_HUMAN
Sequence: MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
What is the function of this protein?
Mediates the activity of CXCL11.
What are the official names of this protein?
C-X-C chemokine receptor type 3, CXC-R3, CXCR-3, CKR-L2, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, IP-10 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Multi-pass membrane protein.
Protein: FIS1_RAT
Sequence: MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS
What is the function of this protein?
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:15979461).  Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (By similarity).  May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity).  Also mediates peroxisomal fission (By similarity).  May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity).  Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity).
What are the official names of this protein?
Mitochondrial fission 1 protein, FIS1 homolog, rFis1, Tetratricopeptide repeat protein 11, TPR repeat protein 11.
What is the protein family that this protein belongs to?
Belongs to the FIS1 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
Protein: RS7_HALSA
Sequence: MSDEQPAEDETEEAAAESEDTQEVAANAKLFGKWDVAEIHYEDPSTRRYLAVTPVAHTMGRHAQKQFKKSEISIVERLANRLMKTGANAGKKQQALKIVRDAFDIVHERTDENPIQVLVSAVENAAPREETVRLKYGGISVPQAVDTAPQRRVDQALKFLADGAHSASFKTPTDAAEALANQLAGAADYNVQTYAIGQKKEKERVAAAAR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: BAT1_HUMAN
Sequence: MGDTGLRKRREDEKSIQSQEPKTTSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAIICLSFSEYVCAPFYVGCKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIIIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLLFYFLFVHYKFGWAQKISKPITMHLQMLMEVVPPEEDPE
What is the function of this protein?
Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:8663357, PubMed:16825196, PubMed:32817565, PubMed:32494597).  Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (PubMed:8663357, PubMed:16825196, PubMed:32494597).  Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (PubMed:8663357).  Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules.
What are the official names of this protein?
b(0,+)-type amino acid transporter 1, b(0,+)AT1, Glycoprotein-associated amino acid transporter b0,+AT1, Solute carrier family 7 member 9.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: Y655_SYNWW
Sequence: MSNVNSYDKAHELARAITKSEPYLNYCQAKKEVEKNPEWTSKLLELRQRQAEFNRAQILGNDIPKETVQELSLEFAHINQINEIAEFFRAETAFVQMFNDIQEIINKAIESGLEA
What are the official names of this protein?
UPF0342 protein Swol_0655.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: BUK2_CALS4
Sequence: MFKVLVINPGSTSTKVALYEDEKEIVRSDITHDVETLKNYKSVIEQLDLRLEAINKWLSENGIKVLELSAIVVRGGLIKPVQSGTYVVNDIMLEDLRKGVGGEHPSNLGGIIGRALADPYGIPVYTLDPVAVDEMEDVARISGLPELPRKSQSHALNIKACIHRYARENNLKEEELNMIVAHMGGGISVAAIKGGRIVDVNNANQMGPFSPERTGSLPSMKVVEMCYSGKYTLEEMKKKIVGMGGLVAHLGTNDAREVVKRIEAGDKKAKLVFEAMAYQIAKEIGRMAAVLKGDVKTIILTGGLAYSKPLIEIIIDMVGFIAPITLYPGGDEMEALRDGALRVLRGQETPKIYG
What are the official names of this protein?
Probable butyrate kinase 2, BK 2, Branched-chain carboxylic acid kinase 2.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STXB_SYNHO
Sequence: MPSDILVVAALGRPFTLGMLYDARNDKLIPGFTLWEDEVIEESTLESSQPSSAFEIIASDSTDDKSSLMDIEASLKASFLGGLVEVGGSAKYLNNQKKFKNQSRVTLQYKATTSFKQLMTNLGTKHVEYSELFENIQATHVVIGILYGANAFFVFDSNKVDSTNVQEIQGQMEAVIKKIPSVEISGKASVQLTGEETDITNSFSCEFHGDFFLTTNPTTFEDAVKTYQQLPQMMGKDNAVPMTVWLVPMVNFYSEAPQLMADSSTPILRKVRNTLEAIVQVQMRCNDALDDPTVNLFTEVQKKLSDFQKICDDHMSKLQATIAKKLFAIRSGDEDESALLNLFEENLQSPFNIESLNMWMEFEEREINVLRSCMDILTKAKPKVIFNQGVLFKGLYDSKVKHALCYVFTNVTKNDVFLNVLNEFLDSPQSRPKKLRPSPKDYWYSYDDIPETMREKAYLFRNLAKEMNNRCVHFFVTAIHNPKQEGAGIHYYRESIQIIDEFTKPYMPGVESIKDRRELQWYDCELTLDPETAHQVLTLSEGNKKAVSGNTKSPTDHLEKFSHFQQVMCTKGLSGRHYWELEWSGYVGAGVTYKGIGRKTSTSDSSLGKNEKSWLFEYSTKSGYQQIHNSKKTRVTVSSTGFKLLGVYLDWPAGTLSFYMVNKAWVTHLHTFHTKFNEAVYPAFLIGDAQQKVNGQIKLL
What is the function of this protein?
This lethal (towards mammals) heterodimer induces hemolytic activities due to its ability to form pores in the cell membrane (PubMed:1790672, PubMed:9271089, PubMed:12177053, PubMed:26627714).  The pore may be composed of 10 SNTX-alpha/beta heterodimers (PubMed:26627714).  The toxin elicits potent hypotension which is endothelium-dependent and appears to be mediated by the nitric oxide pathway and activation of potassium channels (PubMed:8310447, PubMed:11931843).  In addition, it displays edema-inducing activities, increases vascular permeability.  It also shows myotoxic activities and interferes irreversibly with neuromuscular function (PubMed:8079369).  It also induces irreversible platelet aggregation in rabbit or rat but not in human or mouse whole blood (PubMed:8533137).  In addition, it has been observed to increase spontaneous quantal acetylcholine release from isolated frog cutaneous pectoris motor endings (PubMed:8921306).
What are the official names of this protein?
Stonustoxin subunit beta, SNTX subunit beta, DELTA-synanceitoxin-Sh1b, DELTA-SYTX-Sh1b, Trachynilysin subunit beta, TLY subunit beta.
What is the protein family that this protein belongs to?
Belongs to the SNTX/VTX toxin family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into the venom gland lumen (PubMed:8810331). The secretion is proved by the fact that the complete sequence shown in this entry is found in the venom gland's lumen, although no signal peptide has been found (PubMed:8810331). This protein may follow a novel secretion pathway (PubMed:8810331). It has been reported that venom-secreting cells of stonefishes do not possess Golgi apparatus and rough endoplasmic reticulum (PubMed:8810331).
Protein: NANR_CITRI
Sequence: MKTFDSQAENSPAVIGRSLRNRPLARKKLSEMVEEELEQMIRRKEFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTIIGELSGMAKDFLAHPGGIAHFEQLRLFFESSLVRYAAENATDAQIDLLAKALEINSQSLDDNALFIRSDVDFHRVLAEIPGNPIFKAIHVALLDWLIAARPTVPDRELYEHNSVSYQQHIAIVDAIRQRDPDAADRALQTHLNSVSATWHALGQQSKRKK
What is the function of this protein?
Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids.
What are the official names of this protein?
HTH-type transcriptional repressor NanR.
What is the protein family that this protein belongs to?
Belongs to the NanR family.
Protein: BSSS_ECOLI
Sequence: MEKNNEVIQTHPLVGWDISTVDSYDALMLRLHYQTPNKSEQEGTEVGQTLWLTTDVARQFISILEAGIAKIESGDFQVNEYRRH
What is the function of this protein?
Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media.  Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways.  Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway.
What are the official names of this protein?
Biofilm regulator BssS.
Protein: PDXH_SALA4
Sequence: MSDNDQLQQIAHLRREYTKGGLRRRDLPAEPLTLFERWLGQACDARLADPTAMVVATVDDKGQPYQRIVLLKHYDEKGLVFYTNLGSRKAHQIEHNPRISLLFPWHMLERQVMVTGKAERLSTLEVVRYFHSRPRDSQIGAWVSKQSSRISARGILESKFLELKQKFQQGEVPLPSFWGGFRVSIEQMEFWQGGEHRLHDRFLYQRDDGAWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: PEPT_SHEPA
Sequence: MKQQLLERFLSYVSFDTQSDGQNQNVPSTHSQFVFAQHLRQELVSLAFEDVQLSDKGYLTATVPANVEGVPSIGFIAHLDTAPDYSGKNVSPQVIENYNGEDIQLGLAEVLSPKQFSSLNQYIGQTLITTDGTSLLGGDDKAGIAEIISALHHLLTHPEIPHGKIRLCFTPDEEIGRGADHFDVESFGAQWAYTIDGGQVGELEYENFNAATAMITATGNNCHPGTAYGVMVNAQTIAARFHAKMPLKDTPEHSRDYDGFFHLLGMEGVTEKATLTYIIRDFDLELFEKRKQWLTELVEKYNADLSIGQLTIDVQDSYLNMKQQVLPHPHIIDIAKQAMQNLGIEPIIKPIRGGTDGSRLSYMGLPCPNLFTGGHNFHGKHEYVCVESMVKATETIIEIAKLTAEHK
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_THET2
Sequence: MRVVVVGTRGSALALAQTRFVVERLKETWPETEFKIRTIKTRGDQGASPREEAIFVKEIQEALLSREIDIAVHSLKDLPTESPRGLKIASVPRRQDPRDVFLGKAAKRLKDLPPGAVVGTSSVRRKAQILALRPDLVVRDLRGNVDTRLAALGNGEYDGIVLAAAGLIRLDLRNRIDEFLDPGEVLPAPGQGALALEVREGDDLAEELCYALHHPPSYHRVRAERAFLRGLGAGCLAPVGALAHVEEDGTLRLEGVLLTPDGKSFIRAEIEGDVSEAEELGLDLARDVLEQGGREILAQIR
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: GLMU_ACHLI
Sequence: MKNYALVLAAGKGTRMKSDIPKVAFPILRKPMIEYIVENIEKSSVEEIYLVLGYKREVVEGIVKDRAKYVYQEEQLGTGHAAMMAAPVLSKLDGNTFIMPGDVPLIWYKSIDRMFAVHEDNGNDFTIVTAHYEDPEGYGRIVRNEQGVIQRIVEEKDANDFEKEIKEVNTGIYIVNNKKFFSLLKNLNNNNAKGEYYITDMVELMKKDYKIGSYMIKNNSLAMGVNDLYAISKAEKYLREYINKDHMLNGVSMINPETITIGHNVIIEPGVTINPNTTITGDTVIKAGAIVGPNTEIHNSRIDSHVVVRHSLVYDSIVREGTTVGPFAHLRDHADIGTHNRIGNFVEVKKSSTGHNTKASHLAYIGDSVVGESVNFGCGSVTVNYDGKLKHKTEIGDNVFIGCNTNLIAPIKIGDNVFIAAGSTVTKDIPDNGFAIARSRQVTKEDYSKYLISPKPKKEE
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHI_STERE
Sequence: MFPMVTEFMNYGQQTVRAARYIGQGFIITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RPB1_IIV3
Sequence: MTFQPEIADIAKISFGVLSPEEILKMSCCKVTSVKVSDKGENIYSKFMGTIENGENCKTCDRDVWECPGHFGHFHLEVPVVNPIFINDACNILRCICFNCYKFIVSVDHLKLENLVRRFQDILLYVKNIKHCYNCESEKLPLSVVNEIIVDEDKNPLDTRKLLRVLENVDDETVRFLGFNPTMSHPKNFIFTVFPILPPCCRPYVMSEENCCDDDLTYQLIEIIKNNQYLGDEFLKKAELKRKKSLLQSSLPPTTDIKQKHLTNLWFRISTYFNNSKKKAKHAATAKPITGLKERIAGKEGQIRHNLLGKRCDQSGRTVVGPDPTLRLNELCVPKEMAEILTIPVHVTPFNRDALTQLVNSNKANFLIKAANPKRSINLKNVINYRGTLLYFGDIIERDGTRITITDTKFVLQPGDTIIRNGKALKEIRYPERKQIELEVGDVIKRQLMDGDYVLLNRQPTLHKASMMAFKVVIKPVKTLKINLAITKPFNCDFDGDEMNIHVPQSYEAIAELKELSCASKCIMSVQNGKPNVAIVQDSLIGLWFLSRDQWFCQTLKRSQFFNLLLTIDKAQNFLTRMDQICHVLKSKFPSKGNWEGSGLDGDGRVSPKVGRMVFNGRGLLSFLFPYDFDYCGGDGLSIESGVFLEGTLEKNVVNTLIKYIYKDYGETVVADFVDNIQFLTNHYLVDRGFTINASDCLKNESIAPEIVSLTRATFSKATTVRDVTINPFIQEQKTLAILNSCTDQCMKLSKECLSSDNNFCVTTESGSKGSIFNICQITSLLGQQTIDGKRVYGLLHPQDNEFQDRGFIANSFVEGLSPREFLHHAMAGRKGVIDTALLTSVSGYGQRQGVKLNEDIKIYPDYTVRDVNGRLYQYIFGEAGYDPSQTIVVDGHQTICNVYRLVNRLNRSYDSSALRPLTEDEIEWMVDFIQPRREYEYIPPDVEQRICSIRRDPIVGQLRRIQTVDALVPILKSHLEKCFYQTLMSPGECVGIIGAQSMGEFSTQATLNTFHVAGSTTTGAVTNCLTRFQEINNATKNPKNITCKVYFTKGNGTIEEIRRRGKDVKHIVFRDVVEKWTVEPATAEWWYATFKQLYAAPIAESGTVTKRVRFHLKRDIVFAYRISPQEIKQSLESKFDVSCIFSPFDEGLILDVFGKIEPHKLEAFVALMLPTYISGLEGIKAISYHKCDELKIWYIQTSGGTLSDFYTLDDIDVEHTTTNNIWDIYHTLGIEAAREFRIKELVEIIGTGVDLSHIKLRADRLTFTGTIQSLTRYTMRGEKPFSKVGFEEIMENFYKTARDAEVDDLTGVSASIMCGKRAKVGTSMFDIKLNLDAILCPPSTSPLLTTEDGTTSATTPIAATTPEQEDDEAFVDYDYT
What is the function of this protein?
Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Forms the polymerase active center together with the second largest subunit (By similarity).
What are the official names of this protein?
Probable DNA-directed RNA polymerase II subunit RPB1 homolog.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: PBLD_RAT
Sequence: MKLPIFIADAFTVTAFHGNPAAVCLLESILQEDAHQQIAREMNLSETAFIRKLQPTDSFSQSSCFGLRWFTPVSEVPLCGHATMASAAVLFHKIKNVNSTLTFVTLSGELKARRAEDGIVLDFPLYPTFPQDFHEVKDLIKAAIGDTTVQDIQYSPDTRKLLVRLSDSYDRSFLESLKVNTEPLPGIEKTGKVKGLILTVKGESGGQTTPYDFYSRYFAPWVGVPEDPVTGSAHTVLSSYWSQQLGKKEMRAFQCSCRGGELDISLRPDGRVDMKGGAAVVLEGMLTA
What are the official names of this protein?
Phenazine biosynthesis-like domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the PhzF family.
Protein: ATL4_MOUSE
Sequence: MESWLGRLWLCMMLLLPLPQPCQDQELFGPSHQLPSEEGQVPEGLWGPWGRWASCSQPCGVGVQRRSRTCELHPALPLPPRPPRHPEAHRPRGQGSRPQTPRDPQSLYRPQPRGRGGPLRAPASQVGREETQEPQGAQRFRVRDPIKPGMFGYGRVPFALPLHRSRRHPHRPGQPKNSSTGEGMVPSQPPSTELASEKHGPHMQPPEPRSHSAETPRSGTAQTEVLPRTSSAPSYTGTPAPTSSFGDSRSFQGSLGPRMPPSPGSWSSPQGAERRHPPPFSPVPRSQQSRRHWRPPGPHRSPDGWLPLTRDSSPLWSIFAPSIPAPNCSGESEQMRACSQEPCPPEQPDPRALQCAAFDSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGSLDICVAGRCLSPGCDGVLGSGRRPDGCGVCGGDGSTCRLVSGNLTDRGGPLGYQKILWIPAGASHLHISQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYTAIGTVFQYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEDNPGVFYQYVISSPPAVLESPSTKPPALQPQPEMLRGEPLLPSAPRPVRAPGTLQRQVRIPQVPPPTRVRTAMGSSAGYWKQVGHSECSASCGKGVWHPIFLCISRESGEELDEQSCAVGARPPASPEPCHGPPCPPYWEAGEWTSCSRSCGPGTQHRQLLCRQEFGGGGSSVPPERCGHLPRPNITQPCQLHLCGHWEISSPWSQCSVRCGRGQRSRQVRCVGSNGDEVDKQECASGPPPPPSREACDMGPCTTAWFYSDWSSKCSAECGTGIQRRAVVCLRSGETLQGDPEAGSTEQGCPLRSRPPDMRACSLGPCERTWRWFTGPWSECSSECGSGTQHRDIICVSKLGAEFNVTSPSNCSHLPRPPALQPCQGQACEDKWFSTLWSPCSRSCQGGMQTREVQCLSGNQTLSSRCPPHLRPSRKRPCNSQPCNQRPDDQCKDSSPHCPLVVQARLCVYPYYTTTCCRSCAHVLEQSQLEPA
What is the function of this protein?
Positive regulation of apoptosis.  May facilitate FBN1 microfibril biogenesis (By similarity).
What are the official names of this protein?
ADAMTS-like protein 4, ADAMTSL-4, Thrombospondin repeat-containing protein 1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Note=Colocalizes with FMN1 microfibrils in the eye ECM.