PharMolix/UniProtQA huggingface dataset:
Protein: PDLI4_MOUSE
Sequence: MTHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPENKNWPSAPDDKAQAHRIHIDPESQDCSPATSRRSSVSGISLEDNRSGLGSPYGQPPRLPVPHNGSSNEATLPAQMSALHVSPPTSADTARVLPRNRDCRVDLGSEVYRMLREPAEPTASEPKQSGSFRYLQGMLEAGEGGDRPGSGGPRNLKPAASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCENHAKARVKPPEGYDVVAVYPNAKVELV
What is the function of this protein?
Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation.  Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle.  Involved in reorganization of the actin cytoskeleton (By similarity).  In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers.  Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane.  Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton.  Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity).
What are the official names of this protein?
PDZ and LIM domain protein 4, LIM protein RIL, Reversion-induced LIM protein.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, dendritic spine. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Synapse, synaptosome. Note=Localizes to actin stress fibers in nonmuscle cells. Colocalizes with GRIA1 in early endosomes. Enriched in numerous but not all spine-like structures along dendritic branches. Colocalizes with actin and enriched at sites containing larger amounts of actin and alpha-actinin. Targeted efficiently to spines via its PDZ domain-mediated interaction with the alpha-actinin/actin cytoskeletal complex. Localizes to synaptosomes in brain (By similarity). Colocalizes with F-actin. Colocalizes with TRIP6 at cell-cell contacts and lamellipodia. In the cytoplasm, displays a fibrillar pattern with characteristic thick fibers and occasional clusters. Colocalizes with the actin stress fibers. Oxidative stress induces redistribution from cytoskeleton to cytosol. Colocalizes with SRC at the perinuclear region, but not at focal adhesions (By similarity).
Protein: PSBA_LOBMA
Sequence: MTAILERRESENLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLTAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEAPSTNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RS18_YERPS
Sequence: MARYFRRRKFCRFTAEGVVEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARCIKRARYLSLLPYTDRHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: AZOR2_BACAN
Sequence: MSKVLFVKANDRPAEQAVSSKMYETFVTTYKEANPNTEITELDLFALDLPYYGNIAISGGYKRSQGMELTAEEEKAVATVDQYLNQFLEADKVVFAFPLWNFTVPAPLITYISYLSQAGKTFKYTANGPEGLAGGKKVVVLGARGSDYSSEQMAPMEMAVNYVTTVLGFWGITNPETVVIEGHNQYPDRSQQIVEEGLENVKKVAAKF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 2, Azo-dye reductase 2, FMN-dependent NADH-azo compound oxidoreductase 2, FMN-dependent NADH-azoreductase 2.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: YIZK_SCHPO
Sequence: MTFQRSLRDGFHRLINFYFYPSYHDTVVHNLAFSTSDYIYFKHLTDRNDDALLKVDQTINKTNRFIFRKLKILCPSFLNYSFINIYCFGPYTMVGEEFLFF
What are the official names of this protein?
Uncharacterized protein C1002.20.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: EX7S_LACPL
Sequence: MAEQPTFEQNLSQLETIVNQLEQGDVPLEQALDQFQKGVALSKQLQATLEGAEKTLTKMMNENGDEVPFEQADANE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM52_PHATC
Sequence: MTTRVTGNERRGRQLLLRFSGFLSAALTVMALITATRALAPVVAYIAPQRVRSHFMRRAFASGNCRSRRFSVLRSTVGTETRNENNITTPYHSPLPTSRYVYQSSRTLSSRNPALPLESTLMHSNANELTDVELKNLVAHWRDHPVLNPMVTFRSWVVPIKGKMIQAILNSKSLQPYLASRHELLQEMHVRLKIVRDYTDSTDGTEKLILLHPDTPPLSELPADVQQLLRNCQIHENGPVMPTKFTYKDFTASYILSQLLPIAVHPPPTAFETIGHVAHLNLKERHWPYRFLIGQVLLETLPLIESVINKVGEVSGPYRTYDFGLLAGRNDTRVKLTESGVQLQFDLADVYWCSRLSEERQRLLRTFQPGQIIADPFCGVGALCLLAASLPQRNCTIWANDWNPKAVEYLRENARRNHVSDRIERLQCGDAYDFLMDMGLQQHQKASTRSRKEDVTNKDGNHVTPTEPMRLPDHVVMNYPVEAPKFLGALRWWPVPPSSRRGSTTRDGGIGSVIVPRVHVYTFARADPTTDRDAEEVAVDLVAANLLPLGNTIHCRTEMNEDYDCDIQVHPVRDVAPGKVVLCGDFR
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase 2, M1G-methyltransferase 2, tRNA [GM37] methyltransferase 2, tRNA methyltransferase 5 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Protein: XDH_FELCA
Sequence: MTADELVFFVNGKKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRFQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKSRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTIEEIEDAFQGNLCRCTGYRPILQGFRTFARDGGCCGGSGNDLNCCMNQKTDHKITLSPSLFNPEEFTPLDPTQEPIFPPELLRLKDTPQKQLRFEGERVTWIQASTLQELLDLKAQDPEAKLVVGNTEIGIEMKFKNMLFPKMVCPAWIPEPVEHGPEGISFGASCPLSLVEKTLLDAVANLPAHQTEVFKGVLEQLRWFAGKQVKSVASIGGNIITASPISDLNPVFMASGAKLTIVSTGTRRTVRMDHTFFPAYRKTLLAPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFNPGTAQVKELALCYGGMHDRTVSALQTTRKQISNFWNEELLQNVCAGLAEELSLAPDAPGGMVEFRRTLTLSFFFKFYLTVLQKLGIQNSKDKCGKLDPTHASATLLFQKDPPANVQLFQEVPKGQCEEDMVGRPLPHLAAAMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAQKVPGFVCFISADDVPGSNITGIGNDEMVFAKDKVTCIGHIIGAVVTDTREHAQRAAQAVRITYEDLPAIITIEDAIAKDSFYEPELKIEKGNLTKGFSEADNIVSGELYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTTKTQSFVANMLGVPANRILVRVKRMGGGFGGKETRSTVVSTAVPLAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGRVVALKVEHYSNAGNTLDLSQSIMERALFHMDNCYNIPNIRGTGRICKTNLPSNTAFRGFGGPQGMLIAEHWMSEVAVTCGLPAEEVRRKNMYKEGDLTHFNQKLEGFTLPRCWEECLASSQYHARKREADKFNEENCWKKRGLSIIPTKFGISFTVPFLNQAGALVHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVSTDINGQAVYEACQTILKRLEPFKKKNPSGSWEDWVTAAYLDAVSLSATGFYKTPNIGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPSEFRVSLLRDCPNKKAIYASKAVGEPPLFLAASIFFAIKDAICAARAGNPDCKTKKLFQLNSPATPEKIRNACVDQFTRLCVTGTAESCKPWSVRV
What is the function of this protein?
Key enzyme in purine degradation.  Catalyzes the oxidation of hypoxanthine to xanthine.  Catalyzes the oxidation of xanthine to uric acid.  Contributes to the generation of reactive oxygen species.
What are the official names of this protein?
Xanthine dehydrogenase/oxidase.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome. Secreted.
Protein: HSLV_NITEU
Sequence: MTTIVSVRRGRQVALGGDGQVTLGAVVAKASARKVRRLYHNKVLAGFAGGTADAFTLFERFEAKLEKHQGHLMRSAVELAKDWRTDRILRRLEAMLVVADHEATLIITGAGDVIEPEQGIAAIGSGGAYAQAAARALLENTDLSPKEIVTKALTIAGDICIYTNQVHVIEQLD
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHB2_YEAST
Sequence: MNRSPGEFQRYAKAFQKQLSKVQQTGGRGQVPSPRGAFAGLGGLLLLGGGALFINNALFNVDGGHRAIVYSRIHGVSSRIFNEGTHFIFPWLDTPIIYDVRAKPRNVASLTGTKDLQMVNITCRVLSRPDVVQLPTIYRTLGQDYDERVLPSIVNEVLKAVVAQFNASQLITQREKVSRLIRENLVRRASKFNILLDDVSITYMTFSPEFTNAVEAKQIAQQDAQRAAFVVDKARQEKQGMVVRAQGEAKSAELIGEAIKKSRDYVELKRLDTARDIAKILASSPNRVILDNEALLLNTVVDARIDGRGK
What is the function of this protein?
Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
What are the official names of this protein?
Prohibitin-2.
What is the protein family that this protein belongs to?
Belongs to the prohibitin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side.
Protein: MTRM_DROME
Sequence: MENSRTPTNKTKITLNRTPTLKERRWNTLKVNTSNVRCSTPIFGNFRSPNLSPIENMGTKGKSPVSPMRFATFKKVPTKVHPKQQQQQQHQHCHRTQLKPPPFVLPKPQEEIIEPEREIKSCSSPDTCSDDSNMETSLALESRRRSIKASNHSYVVNHAANVEQILMHMGLENYVTNFEEAHIDLVELASLERADLVKIGLNTDEDCNRIMDVLHTL
What is the function of this protein?
Polo kinase inhibitor required to maintain G2 arrest in the meiotic cell cycle in females (PubMed:18052611).  Holds heterochromatically paired homologs together from the end of pachytene until metaphase I (PubMed:14573476).  Haploinsufficient locus for homologous achiasmate segregation and may be required for the maintenance of heterochromatic pairings (PubMed:14573476).
What are the official names of this protein?
Protein matrimony, Cell cycle arrest protein D52.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SYC_LIGS1
Sequence: MLQLYNTLTNQKEKFEPLNPGKVTMYVCGPTVYNYIHIGNARSAVAFDTIRRYLEYRGFEVNYVSNFTDVDDKIIKASQEMNLSVKEITEKFINAFYEDTSALNVKKATLNPRVMDNMDDIIKFIEVLVQKGYAYESAGDVYYKTRKFKDYGKLSGQLIDDLEQGASSRVDDIDQDKKQDPLDFALWKKVKQGEISWNSPWGQGRPGWHIECSVMSTKYLGDTIDIHAGGQDLEFPHHENEIAQSEAKTGKKFARYWLHNGFVTIGEEDQKMSKSLGNFVTVHDLLKKVNPQVIRFFMSTTQYRRPIRYSSANLNEAKVNLNKLQTAYENLSYRLKDSVEGNDKEVEVNFANLEKDFVKVMDDDFNVQNGISVVYEMAKQLNVYSEKEKVYTDTINNLINTYKKVVEIFGISFSEEKELLDDTIEQLIQERNEARKNKNFKRSDEIRDLLKEQGIILEDTAQGTRWKRND
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGB_STAA3
Sequence: MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDNVSTFNLDEYVGLTASHPQSYHYYMDDMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDVLEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTESTIKANSRYFKNEDDVPKQAISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACPKNVAKIHVDEMD
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: BETA_ECOHS
Sequence: MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEGDSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGTECQTDEQLDEFVRNHAETAFHPCGTCKMGYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALPRSTAGYFVANGMPVRAKK
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: Y2636_MYCTU
Sequence: MINPTRARRMRYRLAAMAGMPEGKLILLNGGSSAGKTSLALAFQDLAAECWMHIGIDLFWFALPPEQLDLARVRPEYYTWDSAVEADGLEWFTVHPGPILDLAMHSRYRAIRAYLDNGMNVIADDVIWTREWLVDALRVFEGCRVWMVGVHVSDEEGARRELERGDRHPGWNRGSARAAHADAEYDFELDTTATPVHELARELHESYQACPYPMAFNRLRKRFLS
What are the official names of this protein?
Putative O-phosphotransferase Rv2636.
What is the protein family that this protein belongs to?
To S.violaceus chloramphenicol 3-O phosphotransferase.
Protein: MNMC_SHESW
Sequence: MTAEPNKPCQIKRDYPQLINLYPATAHNDAHYLSKLSIYQQRVFEAHSQQKLLVLGQMGLGNGLELLSWWRTQTNPNQRLLLKVFEPHPINAYELKLLWDQSASLAKVPELELLAQRLLHTEPTAIIGCQRLIFDDGRTTIDLHFGDIQSQLSSLIHSPLHPVQHWLVLPHLQNGLHQQIHWQMAKLSDDSATVATIGLNESSGLSETTVNRFQACGFEVRDFTCAEIQTNPQPDAILLHERHVLRRQDAKAYAFNPMAAILSSDAPSSIAIIGGGLASAHLALSLAERGQSTQIFCKDAKLGQGASGNRQGAIYPLLTPENDELSRFFQQAFLFSRRRVQALTSAPAPNQTPISHNFCGVLQTAHDERSQLRLDKIIQSQNWPSEIAYRVDAQQANCLANINIDKSGFFYPLAGWVCPYEYAEAALQKAQQLTEVKLHLETEILEIEHQSEGWYLITAKHRFGPFAQVVLANGAALTQFDASNKLQISPFRGQVSHVPAQFQLSQLATVLCANGYLTPSHEGLHCLGASYVKEPKHLDFCPQEQQENLAKMHESYPDQGWLDDIDMSGNNARVGVRMVTRDHFPMMGCAPDVPKIIKDYAQHQLTKESRHYWQTTPAPVHEGLYILGGLGSRGLSSGPLAAECLAAQLCSEPIPLDKATLCKLNPNRMWLRKLLKGKSL
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPD_RHOBA
Sequence: MNCAASVSVIMPAAGSGQRFGSQSNKLFAHLDGKPLWQHAIDRFQHRGDVRQIVLAVSEEDESRFREQIAAISSAVPIHLVRGGATRSESVGAALEQVKRFAAESAAANASTQTLVAIHDAARPLVRQSDLDRVIAKAAETGAAILAAPVSGTLKRATGDGSETVDRRNTYVALTPQVFAIDVICQAYARDRGRMATDDAQLVERTSHPVQLVTGSADNLKITFPEDLRIAEAILNECRSEFV
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: UL20_PSHV1
Sequence: MADASAPDKKNAPTNALKPDLIKIAVERVLAAIDTENNEDLILAAAREPREVVAARAPDLFTSAAYSWSEEDELGTRMRASSFFPVASMFAKIICCLFLLWAKSCTGHGAMVTGLTACTGAYAIASLLCSFVVYYNVRTDNMPFGTYTKLFQIAACIGCGCYALGLTMEKLFGDSEMYFALFPDAKNSPLVGATAKGSALILPQGCSVAPYVPLAVSVAYCAAVVYDIADTIFPLLWVRTTLNEFAVF
What is the function of this protein?
Plays an essential role in egress of virus particles from the nucleus, cytoplasmic envelopment and virus-induced cell fusion.  Forms a functional protein complex with gK and this interaction is absolutely essential for their coordinate intracellular transport, gK glycosylation, expression on host cell surface, and function.  Together, they modulate gB-mediated virus-induced cell fusion and virion egress and therefore actively participate in these processes (By similarity).
What are the official names of this protein?
Protein UL20.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae UL20 family.
What are the subcellular locations of this protein?
Virion. Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host nucleus membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with gK to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN) (By similarity).
Protein: TTDT_SHISS
Sequence: MKPSTEWWRYLAPLAVIAIIALIPVPAGLESHTWLYFAVFTGVIVGLILEPVPGAVVAMVGISIIAILSPWLLFSPEQLAQPGFKFTAKSLSWAVSGFSNSVIWLIFAAFMFGTGYEKTGLGRRIALILVKKMGHRTLFLGYAVMFSELILAPVTPSNSARGAGIIYPIIRNLPPLYQSQPNDSSSRSIGSYIMWMGIVADCVTSAIFLTAMAPNLLLIGLMKSASHATLSWGDWFLGMLPLSILLVLLVPWLAYVLYPPVLKSGDQVPRWAETELQAMGPLCSREKRMLGLIVGALVLWIFGGDYIDAAMVGYSVVALMLLLRIISWDDIVSNKAAWNVFFWLASLITLATGLNNTGFISWFGKLLAGSLSGYSPTMVMVALIVVFYLLRYFFASATAYTSALAPMMIAAALAMPEIPLPVFCLMVGAAIGLGSILTPYATGPSPIYYGSGYLPTADYWRLGAIFGLIFLVLLVITGLLWMPVVLL
What is the function of this protein?
Catalyzes the uptake of tartrate in exchange for intracellular succinate.  Essential for anaerobic L-tartrate fermentation (By similarity).
What are the official names of this protein?
L-tartrate/succinate antiporter, Tartrate carrier, Tartrate transporter.
What is the protein family that this protein belongs to?
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOC_SALRD
Sequence: MPYGNSKEIETDFDSITISLASPEDILERSYGEVMKPETINYRSFKPEMGGLFCEKIFGPVKDYECHCGKYKRIRYKGIICDRCGVEVTRKAVRRERMGHISLSVPVVHIWYFKTLPNKIGHLLGLKSKDLEKVIYYENYIVIQPGTAERLGVEENQLLTEEEYYEILYQIRDDNNRLQDDNEEKFIAKIGGEAVETMLERLELDKLAQELRYQVRTETSQQRKSKALKRLDVVEAFREANEDGTNKPEWMVMRVIPVIPPELRPLVPLDGGRFATSDLNDLYRRVIIRNNRLKRLIDIKAPEVILRNEKRMLQEAVDSLFDNSRKSNSVRGSSNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVSGPHLELHQCGLPKEMAVELFKPFIIRRLIERGIVKTVKSAKKYVDKKTEDVWDILEKVIQGRPVLLNRAPTLHRLGIQAFQPVLTENKAIEIHPLVCPAYNADFDGDQMAVHVPLSHEACLESMVLMLSSHNVRSPADGGPLAVPSQDMILGLYYITKAKSNQKGEGMRFANVQEVRQAFDQDQVALHAKIQLRDPDGSGEMIDTTVGRVIFNETLPDTLDYVNEVLSTKNVRPVIARVLKQTGFEETADFLDAIKDMGFRRSTTSGMTFSLSDIIIPDEKEELIEEANETVEEAEQNYSMGFITDNERYNQVIDVWTKTNNKVSEVLFDALKEHKEGFNPIFTMADSGARGSQEQIRQLGGMRGLMAKPQKNIGEGGGGGEILENPILSNFKEGLTVQEYFISTHGSRKGLADTALKTADAGYLTRRLVDVSQSVTVTEHDCGTLRGINVGALKDNEEVVAPLSDRITGRVSVRDVYDPHTDELIVEANELITDEIADDIAQTSIEEIEIRSVLTCEAERGVCTLCYGQNLATGRMVEVGESVGVVAAQSIGEPGTQLTLRTFHTGGTATREVGESTIQAKFAGTLEFENLRTVTYEDTDGPKEVVLSRQGEVRIMDTDGDRRELTSYVVPYGAELLVDEGEDVEDGDVLASWDPYNSLILTEANGTVRFEDIIEDTTYREETDEQTGHKEKVIVESRERTLTPAVIVETEDGEQREYNMPVDARIQVDEGDEVQAGQTLAKMPRQAAQTSDITGGLPRVEELFEARTPDEPAVVSEIDGIVSFGDQKRGSQEVIVTSRDGDMEKSYMVSLSKHMLVHEGDYVEAGDRLCDGQIAPHDILSIKGPRAVQEHLLNEVQEVYRLQGVDIDDKHFEVVIRQMMKRVKITEPGDTNFLEEDQVDRQKMASINDDLYDKFVVKDPSDANVEIGEVIGRRRLRELNSELKREDKPEIEVREARPAVGEPLLLGITKASLATDSMISAASFQETTKVLTNSAIRSRTDPLEGLKENVVAGHSIPAGTGQREYRDLVVGSKSELEELQAAIGGDGESPSGDGAAGDGAPSEEDVEQIEASGSEN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: COIA1_HUMAN
Sequence: MAPYPCGCHILLLLFCCLAAARANLLNLNWLWFNNEDTSHAATTIPEPQGPLPVQPTADTTTHVTPRNGSTEPATAPGSPEPPSELLEDGQDTPTSAESPDAPEENIAGVGAEILNVAKGIRSFVQLWNDTVPTESLARAETLVLETPVGPLALAGPSSTPQENGTTLWPSRGIPSSPGAHTTEAGTLPAPTPSPPSLGRPWAPLTGPSVPPPSSGRASLSSLLGGAPPWGSLQDPDSQGLSPAAAAPSQQLQRPDVRLRTPLLHPLVMGSLGKHAAPSAFSSGLPGALSQVAVTTLTRDSGAWVSHVANSVGPGLANNSALLGADPEAPAGRCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLLLVPPCGSVPPPAPPPCCQFCEALQDACWSRLGGGRLPVACASLPTQEDGYCVLIGPAAERISEEVGLLQLLGDPPPQQVTQTDDPDVGLAYVFGPDANSGQVARYHFPSLFFRDFSLLFHIRPATEGPGVLFAITDSAQAMVLLGVKLSGVQDGHQDISLLYTEPGAGQTHTAASFRLPAFVGQWTHLALSVAGGFVALYVDCEEFQRMPLARSSRGLELEPGAGLFVAQAGGADPDKFQGVIAELKVRRDPQVSPMHCLDEEGDDSDGASGDSGSGLGDARELLREETGAALKPRLPAPPPVTTPPLAGGSSTEDSRSEEVEEQTTVASLGAQTLPGSDSVSTWDGSVRTPGGRVKEGGLKGQKGEPGVPGPPGRAGPPGSPCLPGPPGLPCPVSPLGPAGPALQTVPGPQGPPGPPGRDGTPGRDGEPGDPGEDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVGERGPPGPQGPPGPPGPSFRHDKLTFIDMEGSGFGGDLEALRGPRGFPGPPGPPGVPGLPGEPGRFGVNSSDVPGPAGLPGVPGREGPPGFPGLPGPPGPPGREGPPGRTGQKGSLGEAGAPGHKGSKGAPGPAGARGESGLAGAPGPAGPPGPPGPPGPPGPGLPAGFDDMEGSGGPFWSTARSADGPQGPPGLPGLKGDPGVPGLPGAKGEVGADGVPGFPGLPGREGIAGPQGPKGDRGSRGEKGDPGKDGVGQPGLPGPPGPPGPVVYVSEQDGSVLSVPGPEGRPGFAGFPGPAGPKGNLGSKGERGSPGPKGEKGEPGSIFSPDGGALGPAQKGAKGEPGFRGPPGPYGRPGYKGEIGFPGRPGRPGMNGLKGEKGEPGDASLGFGMRGMPGPPGPPGPPGPPGTPVYDSNVFAESSRPGPPGLPGNQGPPGPKGAKGEVGPPGPPGQFPFDFLQLEAEMKGEKGDRGDAGQKGERGEPGGGGFFGSSLPGPPGPPGPPGPRGYPGIPGPKGESIRGQPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTISVPGPPGPPGPPGPPGTMGASSGVRLWATRQAMLGQVHEVPEGWLIFVAEQEELYVRVQNGFRKVQLEARTPLPRGTDNEVAALQPPVVQLHDSNPYPRREHPHPTARPWRADDILASPPRLPEPQPYPGAPHHSSYVHLRPARPTSPPAHSHRDFQPVLHLVALNSPLSGGMRGIRGADFQCFQQARAVGLAGTFRAFLSSRLQDLYSIVRRADRAAVPIVNLKDELLFPSWEALFSGSEGPLKPGARIFSFDGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSATGQASSLLGGRLLGQSAASCHHAYIVLCIENSFMTASK
What is the function of this protein?
Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295).  May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity).  Inhibits VEGFA-induced endothelial cell proliferation and migration.  Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2.  Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity).  May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123).
What are the official names of this protein?
Collagen alpha-1(XVIII) chain.
What is the protein family that this protein belongs to?
Belongs to the multiplexin collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, extracellular matrix, basement membrane. SUBCELLULAR LOCATION: [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane. Secreted. SUBCELLULAR LOCATION: [Endostatin]: Secreted. Secreted, extracellular space, extracellular matrix, basement membrane.