PharMolix/UniProtQA huggingface dataset:
Protein: CLPC_STAHJ
Sequence: MLFGRLTERAQRVLAHAQEEAIRLNHSNIGTEHLLLGLMKEPEGIAAKVLESFNITEDKVIEEVEKLIGHGQDQTGTLHYTPRAKKVIELSMDEARKLHHNFVGTEHILLGLIRENEGVAARVFANLDLNITKARAQVVKALGSPEMSNKNATANKSNNTPTLDGLARDLTVIAKDGTLDPVVGRDKEITRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQAIVNNEVPETLKGKRVMSLDMGTVVAGTKYRGEFEERLKKVMEEIHQAGNVILFIDELHTLVGAGGAEGAIDASNILKPALARGELQCIGATTLDEYRKNIEKDAALERRFQPIQVDEPTVEDTIAILKGLRDRYEAHHRINISDEALEAAAKLSDCYVSDRFLPDKAIDLIDEASSKVRLKSHTTPNNLKEIEQEIEKVKNEKDAAVHAQEFENAANLRDKQTKLEKQYEDAKNEWKTTQGDQSTSLSKEDIGEVIAGWTGIPLTKINETESDRLLNLEQTLHDRVIGQNDAVTSISKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESMFGEEDAMIRVDMSEFMEKHAVSRLVGAPPGYVGHDEGGQLTEKVRRKPYSVILFDEIEKAHPDVFNILLQVLDDGHLTDTKGRQVDFRNTVIIMTSNVGAQELQDQRFAGFGGGSEGHDYETIRKTMMKELKNSFRPEFLNRVDDIIVFHKLSKDELKEIVTMMVNKLTQRLSEQDINIVVTDKAKEKIAEEGYDPEYGARPLIRAIQKTVEDNLSELILDGNQIEGKEVVIDHDGDEFKYNINEKNNGISDEGNEVTETEA
What is the function of this protein?
Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpC.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. ClpC subfamily.
Protein: SC5A3_BOVIN
Sequence: MRAVLETADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALFIQESMGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIVGALTLMVISMMEIGGFEEVKRRYMLASPNVTSILLTYNLSNTNSCNVHPKKDALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFADDIACINPEHCMQVCGSRAGCSNIAYPRLVMKLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFILVVVRLTLAFAYRAPECDQPDNRPVFIKDIHYMYVATALFWITGLITVIVSLLTPPPTKEQIRTTTFWSKKSLVVKESCSPKDEPYKMQEKSILRCSENSEVINHVIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKEAEDGSRYWKFIDWFCGFKSKSLSKRSLRDLMEEEAVCLQMLEEPPQVKVILNIGLFGVCSLGIFMFVYFSL
What is the function of this protein?
Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity).  Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity).  Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel.  In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (By similarity).  Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity).  Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity).  Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (By similarity).
What are the official names of this protein?
Sodium/myo-inositol cotransporter, Na(+)/myo-inositol cotransporter, Sodium/myo-inositol transporter 1, SMIT1, Solute carrier family 5 member 3.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COX1_ALBTU
Sequence: IYGSKVQYTASMYWVLGFIFLFTLGGLTGIVLSNSSLDIMLHDTYYVVAHFHYVLSMGAVFAIFAGFNFWFPVMTGLVLHERLAKAQFIVMFIAVNMTFFPQHFLGLAGMPRRYSDYPDSYFMWNQLSSYGSLMSVFAVLLFVLIVWEAFLSQRSLLFVDATLYSREWSDGYFPPDFHSNIYQSYITIYKTYYSK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PUR5_ACIAD
Sequence: MSNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGYEEPVLVSGTDGVGTKLRLALNLNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLNVDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYDLAGFAVGVVEQSKIIDGSKVKAGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQEIDGRSLADAAMEPTRIYVKPVLELCKQVDVHAMAHITGGGLPGNLPRVLPNGAQAVIDEASWEWPELFKLLQREGGVEQFEMYRTFNCGVGMVIAVDAADADKTIQVLNAQGEKSWKIGHIQDNAESIEGADEKIRVIFA
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_SYNAS
Sequence: MELYQLTIHELQNKIRQGGVTSTAIVNSVFGRIDAVEENVHSYITLMRESALEEAQKADEQIRTGEINALTGIPVALKDIYCTRGVRTTCGSLILDNFIPPYDATVVVKLREAGAVFTGKTNMDEFAMGSSTETSYYGFTRNPWDLERIPGGSSGGSAAAVAADECIAALGSDTGGSIRQPAALCGVVGMKPTYGRVSRFGLIAFASSLDQIGPFTKDVEDCAILLNVIAGYDLRDSTSVPVDVPDYRDYLNRGIEGWTVGIPKEYFIEGIDPEVRGAIEQAIRTVEGLGARCREISLPHTDYCVAVYYIIAPAEASSNLARYDGVKYGFRAADCRDLLDMYKKTRSAGFGTEVKRRVMLGTYSLSSGYYDAYYKKASQVRGLIKRDFEEALKDCNVILTPTTPTPAFTIGEKTDDPMQMYLSDIFTISANLAGIPGISVPCGYTQSGLPVGIQFLAGHFEEGKLLQIASAYERNAHIEKRRPIL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: ESC_DROVI
Sequence: MSSEKVKNDNEPDDTDDSCGDESASFTTNSTTSRSKSPASSTRSKRRGRRSHKSKPKSGAAYKYDTHVKENHGANIFGVSFNTLLGKDEPQVFATAGSNRCTVYECPRKGGLTLLHCYADPDPDEVFYTCAWSYDLKTSAPLLAAAGYRGVIRVIDIEQNEAVDNYIGHGQAINELKFHPHKLQLLLSGSKDHAIRLWNIQTHVCIAIFGGVEGHRDEVLSIDFNMRGDRIVSSGMDHSLKLWCLNTQEFQHKIELSQTFSQEKSTLPFPTITKHFPDFSTRDIHRNYVDCVQWFGNFVLSKSCENAIVCWKPGQLHQSFEQLKPSDSSCTIIAEFEYDECEIWFVRFGFNPWQKVIALGNQQGKVYVWEMDPSDPEGAHMTTLHNLRSVATVRQIAFSRDASVLVYVCDDATVWRWNRRHAAAI
What is the function of this protein?
Polycomb group (PcG) protein.  In contrast to other PcG protein, it is specifically required during the first 6 hours of embryogenesis to establish PcG silencing.  PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.  PcG proteins are not required to initiate repression, but to maintain it during later stages of development.  They probably act via a methylation of histones, rendering chromatin heritably changed in its expressibility.  Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.  The Esc/E(z) complex is necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression (By similarity).
What are the official names of this protein?
Polycomb protein esc, Protein extra sex combs.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ESC family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACNB_SALTY
Sequence: MLEEYRKHVAERAAQGIVPKPLDATQMAALVELLKTPPVGEEEFLLDLLINRVPPGVDEAAYVKAGFLAAVAKGDTTSPLVSPEKAIELLGTMQGGYNIHPLIDALDDAKLAPIAAKALSHTLLMFDNFYDVEEKAKAGNEYAKQVMQSWADAEWFLSRPPLAEKITVTVFKVTGETNTDDLSPAPDAWSRPDIPLHAQAMLKNAREGIEPDQPGVVGPIKQIEALQKKGYPLAYVGDVVGTGSSRKSATNSVLWFMGDDIPNVPNKRGGGLCLGGKIAPIFFNTMEDAGALPIEVDVSNLNMGDVIDVYPYKGEVRNHETGELLATFELKTDVLIDEVRAGGRIPLIIGRGLTTKAREALGLPHSDVFRQAKDVAESSRGFSLAQKMVGRACGVKGIRPGAYCEPKMTSVGSQDTTGPMTRDELKDLACLGFSADLVMQSFCHTAAYPKPVDVTTHHTLPDFIMNRGGVSLRPGDGVIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFAAATGVMPLDMPESVLVRFKGKMQPGITLRDLVHAIPLYAIKQGLLTVEKKGKKNIFSGRILEIEGLPDLKVEQAFELTDASAERSAAGCTIKLNKEPIVEYLTSNIVLLKWMIAEGYGDRRTLERRIQGMEKWLADPQLLEADADAEYAAVIDIDLADIKEPILCAPNDPDDARLLSDVQGEKIDEVFIGSCMTNIGHFRAAGKLLDNHKGQLPTRLWVAPPTRMDAAQLTEEGYYSVFGKSGARIEIPGCSLCMGNQARVADGATVVSTSTRNFPNRLGTGANVFLASAELAAVAALIGKLPTPEEYQTYVAQVDKTAVDTYRYLNFDQLSQYTEKADGVIFQTAV
What is the function of this protein?
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route).  Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate.  Also catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate.  The apo form of AcnB functions as a RNA-binding regulatory protein which regulates FliC synthesis via interaction with the ftsH transcript to decrease the intracellular levels of FtsH.  The lower levels of FtsH protease activity then influence sigma-32, DnaK and ultimately FliC production.
What are the official names of this protein?
Aconitate hydratase B, ACN, Aconitase, (2R,3S)-2-methylisocitrate dehydratase, (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase, 2-methyl-cis-aconitate hydratase, Iron-responsive protein-like, IRP-like, RNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: RNS3_PETHY
Sequence: MFRLQLISAFFILLFSLSPVSANFDYFQLVLTWPASFCYPKNKCQRRSNNFTIHGLWPEKKRFRLEFCTGDKYKRFLEEDNIINVLERHWIQMRFDETYANTKQPLWEHEYNRHGICCKNLYDQKAYFLLAMRLKDKLDLLTTLRTHGITPGTKHTFGEIQKAIKTVTSNNDPDLKCVENIKGVMELNEIGICYTPAADRFDRCRHSNTCDETSSTKILFRG
What is the function of this protein?
Self-incompatibility (SI) is the inherited ability of a flowering plant to prevent self-fertilization by discriminating between self and non-self pollen during pollination.  In many species, self-incompatibility is controlled by the single, multiallelic locus S.
What are the official names of this protein?
Ribonuclease S-3, S3-RNase, Stylar glycoprotein 3.
What is the protein family that this protein belongs to?
Belongs to the RNase T2 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: COAA_MYCGI
Sequence: MARLSEPSPYVEFDRAQWRALRMSTPLKLTEDELVRLRGIGEKIDLLEVEEVYLPLARLIHLQVAARQALFATTADFLGEPQQNPDRPVPFVIGVAGSVAVGKSTTARVLQALLARWEHHPRVDLVTTDGFLYSNSELSRRNLMHRKGFPESYDRRGLMRFVTTVKSGSDVACAPVYSHLLYDIVPGEKQIIEHPDILILEGLNVLQTGPALMVSDLFDFSVYVDARIEDIENWYISRFLKMREGAFADPASHFHHYSTLTDEQAVFAARDIWHSINRPNLIENILPTRPRATLVLRKDSDHSINRLRLRKL
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG057_VACCW
Sequence: MWPFASVPAGAKCRLVETLPENMDFRSDHLTTFECFNEIITLAKKYIYIASFCCNPLSTTRGALIFDKLKEASEKGIKIIVLLDERGKRNLGELQSHCPDINFITVNIDKKNNVGLLLGCFWVSDDERCYVGNASFTGGSIHTIKTLGVYSDYPPLATDLRRRFDTFKAFNSAKNSWLNLCSAACCLPVSTAYHIKNPIGGVFFTDSPEHLLGYSRDLDTDVVIDKLKSAKTSIDIEHLAIVPTTRVDGNSYYWPDIYNSIIEAAINRGVKIRLLVGNWDKNDVYSMATARSLDALCVQNDLSVKVFTIQNNTKLLIVDDEYVHITSANFDGTHYQNHGFVSFNSIDKQLVSEAKKIFERDWVSSHSKSLKI
What is the function of this protein?
Major envelope protein that plays a role in the biogenesis of the viral double membrane and in egress of virus from the host cell (PubMed:8999886, PubMed:17475658, PubMed:27466413).  Produces the wrapped form of virus that is required for cell-to-cell spread (PubMed:27466413, PubMed:29540596).  Acts as a lipase with broad specificity including phospholipase C, phospholipase A, and triacylglycerol lipase activities (PubMed:9405398).
What are the official names of this protein?
Envelope phospholipase OPG057, 37 kDa protein, Envelope phospholipase F13, Palmitoylated EV membrane protein, p37K.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG057 family.
Protein: VAM3_YEAST
Sequence: MSFFDIEAQSSKGNSQQEPQFSTNQKTKELSNLIETFAEQSRVLEKECTKIGSKRDSKELRYKIETELIPNCTSVRDKIESNILIHQNGKLSADFKNLKTKYQSLQQSYNQRKSLFPLKTPISPGTSKERKDIHPRTEAVRQDPESSYISIKVNEQSPLLHNEGQHQLQLQEEQEQQQQGLSQEELDFQTIIHQERSQQIGRIHTAVQEVNAIFHQLGSLVKEQGEQVTTIDENISHLHDNMQNANKQLTRADQHQRDRNKCGKVTLIIIIVVCMVVLLAVLS
What is the function of this protein?
Required for vacuolar assembly.  Provides the t-SNARE function in a late step of the vacuolar assembly.  Required for homotypic vacuole membrane fusion, autophagy and fusion of biosynthetic transport vesicles with the vacuole.  Required for the delivery of alpha-factor receptor-ligand complexes to the vacuole.
What are the official names of this protein?
Syntaxin VAM3, Vacuolar morphogenesis protein 3.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type IV membrane protein.
Protein: EFP_RICPR
Sequence: MKISANSIRTGNILVYNNDLWVVSKTPEHTQPGKGGAYVQVEMKNLKTGTKRNDRFSSSDYLEKAELEQKDCQFLYFEGNNLVLMDTKHFDQINVPKEILEAKLPFLTENMIVKVEFYNDKPLTIVLPPTVILAISETDPVIKGATVTSSYKPAILENGIKVKVPQYLAIGEKIVVKTDDMTYVERAK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXD1_MOUSE
Sequence: MDPSSDYHFLNQILWRRVKLTLVSGIFEGVLQHVDPNKIVVLKNVRNAESGRSVPGVKVFFGHEILNVELMDEAEGASGEKASAVSINTERAGMEKVKNEDVNVCEPASPAPEVPTSSLLSDLKYCPSEEEEVTYTVIDQFQQKFGAAMLHIKKQSVLSVAAEGANVCRHGKLCWLQVATNSRVYLFDIFLLGSRAFNNGLQMILEDKRILKVIHDCRWLSDCLSHQYGIMLNNVFDTQVADVLQFSMETGGFLPNCISTLQESLIRHLKVAPRYLFFLEERQKRIQENPEIWLTRPLPPSLLKILALETTYLLPLRLVLLDEVMSDLTTLVDGYLNTYREGSADRLAGTEPACMELPAELLQLQDFQKQRRERAVKEYRVNARGLLIRTPLHPKEPTACTAGKEERVQGFLFYKTDGGDQVPRFLCPKSHEDEKFLDKESKQTTAKSQIVPPRKEGEAHKDSKNKPGCWESAGPEDPRAQKAHALPPTWASQSQFSLKEEIEQLTVVGNKGALTSPKEGALVSPSLLQETWEAPTDTFHLPEKAEVSTLPPCPALEKTDSWISPSLNLF
What is the function of this protein?
RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis.  The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (PubMed:26669262).  The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.  In the PET complex, EXD1 probably acts as an RNA adapter.  EXD1 is an inactive exonuclease (By similarity).
What are the official names of this protein?
piRNA biogenesis protein EXD1, Exonuclease 3'-5' domain-containing protein 1, Exonuclease 3'-5' domain-like-containing protein 1, Inactive exonuclease EXD1, mExd1.
What is the protein family that this protein belongs to?
Belongs to the EXD1 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis.
Protein: TIG_SHEDO
Sequence: MQVSVETTEGLGRRLTISVPAEQIEKMVKDGITREAKRARLPGFRPGKVPLSEINKRYGQAIRQDVMGEVMQRNFIEAIIAEKLNPAGAPTFMPGKSVGESFEFVATFEIYPEITLTGLDTIAVEQPKAEVNDADLDAMIETLRKQHATFAVVERASAAGDKVKMNFVGSIDGEEFDGGKADDFELEIGSNRMIPGFETGVTGHKAGETFDIEVSFPEDYHAENLKGKAAKFAITLTEVQAAQLPEVNDEFATLFGITSGGVDALKAEIRKNMTRELEQALKANVKEQVINGLLAANDVTIPSALIDGEVEVLRKQAMQRFGGQTKNMPELPAELFTEQAERRVKIGLLLGEVIKTSELKAEDSRVQALIASMASAYEDPAEVVAYYNSNKEMMQNMRNVALEEQAVEALLKSAKVTTKEVAFEEFMNKASGRA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: NSK1_SCHPO
Sequence: MAYKLSLSAVEPLLIFPAAPFSTKKEKSTFQNNLISSDVFSSALKPLSPLKSLVADFSTHSNPSKDNQLISPPKINHREFLNEEKESDTQTRYLKQLINICNSPSKNHETSLSPSKSTIDNNERKLDNEIDNYKHDVKYSPYKGQGKTSNPSQGTTKCPGIFEEDNFFSVSPKRRKNLFEKYGKTDLGKPARVPSPKKSLSSTIKSPPSRVKLPTSILSKSPPLKVPNKNRSSTFSPLRTPTSSSKTFVIVDHSTPSPPSIRTKLEAFAPNSTFATQKRLRRLATLESSPALRSTLKSLQSKSSPVKLLKLKEEKAKIKNQLFKSEEEKDPVGKQKLPLESSLSPLDHSSAEKEMQKAPAKNKRRRTGSLETGLYPKESPTPSKKRSKRVLWSLKHIVSPGNREKHSLNSTPESIMKKDTKWPQNLAKNNINSEPNTPTKSNIDTGKAHSARAHKTRKNIQS
What is the function of this protein?
Ensures chromosome alignment and accurate chromosome segregation during mitosis.  Promotes proper kinetochore-microtubule (k-MT) interactions during anaphase B.  The phosphorylation status of nsk1 affects the proper k-MT coupling, ensuring that it interacts stably only at the correct time during mitosis.
What are the official names of this protein?
Kinetochore protein nsk1, Nucleolus spindle kinetochore protein 1.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Undergoes cell cycle-dependent localization changes, nucleolar during interphase, distributed in the nucleoplasm during metaphase, and increased at kinetochores and the spindle during anaphase.
Protein: RL6_BURO0
Sequence: MSRVGKSPIALQGAEVKLADGAITVKGPLGTITQAINPLVNVANNDGTLNLSPVDESREANALSGTMRAIIANAVHGVTKGFERKLTLVGVGYRAQAQGDKLNLSLGFSHPVVHQMPEGVKAETPTQTEIVIKGINKQQVGQVAAEVRGYRPPEPYKGKGVRYADEVVILKETKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: TXP2_PARSR
Sequence: YCQKWMWTCDEERKCCEGLVCRLWCKRIINM
What is the function of this protein?
Potent and specific blocker of Kv4. 2/KCND2 (IC(50)=34 nM) and Kv4. 3/KCND3 (IC(50)=71 nM) potassium channels (PubMed:10051143).  Acts by altering the gating properties of these channels (PubMed:10051143).
What are the official names of this protein?
Kappa-theraphotoxin-Ps1b, Kappa-TRTX-Ps1b, PaTX2, Phrixotoxin-2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 30 (phrixotoxin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: T4S18_HUMAN
Sequence: MGSRKCGGCLSCLLIPLALWSIIVNILLYFPNGQTSYASSNKLTNYVWYFEGICFSGIMMLIVTTVLLVLENNNNYKCCQSENCSKKYVTLLSIIFSSLGIAFSGYCLVISALGLVQGPYCRTLDGWEYAFEGTAGRFLTDSSIWIQCLEPAHVVEWNIILFSILITLSGLQVIICLIRVVMQLSKILCGSYSVIFQPGII
What are the official names of this protein?
Transmembrane 4 L6 family member 18.
What is the protein family that this protein belongs to?
Belongs to the L6 tetraspanin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DSE_BOVIN
Sequence: MRTHTRGAPSVFFICLFCFVSACVTDENPEVMIPFTNANYDSHPMLYFSRAEVAELQLRAASSHEHIAARLTEAVNTMLSSPLEYLPPWDPKEYSARWNEIYGNNLGALAMFCVLYPENMEARDMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQQEKFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLVLMNQGYLQEAYLWTKQVLTIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLVQRHFDINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPESQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLWYDASLKSVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALYGPKYTFFNNVLMFSPAASKSCFSPWEGQVTEDCSSKWSKYKHDPAASCQGRVVAAVEKNGVVFIRGEGVGAYNPQLHLRNVQRNLILLHPQLLLLVDQIHLGEDSPLERAASFFHNVDFPFEETVVDGVHGALIRQRDGLYKMYWMDDTGYSEKGTFASVTYPRGYPYNGTNYVNVTTHLRSPVTRAAYLFIGPSIDVQSFSIHGDAQQLDVFVATSEHAYATYLWTGETAGQSAFAQVIADRQKILFDRSSAIRSSVVPEVKDYAALVEQNLQHFKPVFQLLEKQILSRVRNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQQQQQQQSKSKKNRRGGKRYKFVDAVPDIFAQIEVNERKVRQKAQILAQKELPVDEDEEMKDLLDFADITYEKHKNGDVMNGRFGQARMVTTHSRAPALSASYTRLFLILNIAIFFVMLAMQLTYFQRAQSLHGQRCLYAVLLIDSCILLWLYSSCSQSQC
What is the function of this protein?
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.  Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
What are the official names of this protein?
Dermatan-sulfate epimerase, DS epimerase, Chondroitin-glucuronate 5-epimerase.
What is the protein family that this protein belongs to?
Belongs to the dermatan-sulfate isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Protein: HAT2_ASPFU
Sequence: MEPYDDAVVEEHEEQEEERTEEKIINEEYKTWKKNAPFLYDMILSTALEWPTLTTQWLPDKQEVPDKPYSTHRLLIGTHTSSDAQNYLQIAHVQLPNPSAPNPDDYDEERGEIGGYGGSSKKAPMEIKFNIVQKIDHKGEVNKARYQPQNPNIIATMCTDGRVMVWDRSKHPSLPTGQVNPQMELIGHTKEGFGLSWSPHTAGQLATGSEDKTVRIWDLTTYSKGNKLLKPSRTYTHHSSIVNDVQYHPLHSSLIGTVSDDITLQILDIRESETTRAAASTEGQHRDAINAIAFNPAAETVLATGSADKTIGLWDLRNLKTKLHSLESHTDSVTSISWHPFEEAVLASASYDRKIAFWDLSRAGEEQTPEDAQDGPPELLFQHGGHTNRISDFSWNLNDPWVLCSAAEDNLLQVWKVADAIVGKDLEDVPTEELEP
What is the function of this protein?
Regulatory subunit of the histone acetylase B (HAT-B) complex.  The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing.
What are the official names of this protein?
Histone acetyltransferase type B subunit 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.