PharMolix/UniProtQA huggingface dataset:
Protein: NDHI_SACOF
Sequence: MFPMLTGFISYGQQTIRAARYIGQGLIITLSHTNRLPITIHYPYEKSITSERFRGRIHFEFDKCIACEVCVRVCPIDLPLVDWKFEKDIKRKQLLNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALSRLPISIMGDYTIQTIRNSPQSKIDEEKSWNSRTITDY
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: HRCA_CORDI
Sequence: MAGATDQRRQEVLRAIVADYIASQEPVGSKALLERHNLKVSSATIRNDMAVLESEGYIVQQHASSGRIPTEKAYRTFVDSINDIKPLSVAERRAILGFLERGVDLEDVLKRSVQLLSQLTRQAAVIQLPNLNVSRVKHCEVVLLSPVRLLLVLITDNGRVEQRNVEVDQICEPEHVAKMRDVLNRALDNKTLSDASASLAELAAGEILVDPDIQPMILRCATVLIETLVEQPNDRLILAGASNLTHIAREMPSSLPAMLEALEEQVVVLKLLTNVRDLGHVSVLIGEENEDEQLRGTSVVTTGYGAQGATLGGLGVVGPTFMDYSGTMSKVYAVAHYVSRVLSGG
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: PYRR_MACCJ
Sequence: MDKRIILDDKAIDRTLTRIAHEILENNKGAHDLVLLGIRTRGIYLAQRIQSKIEKIDGITVPTGVLDVTQYRDDITDRVSQDVVAYKIDTDMNNRHVVIVDDVLYTGRTVRASLDAILDHVRPKRISLATLIDRGHRELPIRADFIGKNIPTALSEEIVVMLDEVDDKTQVYIK
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: BRMS1_HUMAN
Sequence: MPVQPPSKDTEEMEAEGDSAAEMNGEEEESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQRSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLQGELQERIQRLEEDRQSLDLSSEWWDDKLHARGSSRSWDSLPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKSDGP
What is the function of this protein?
Transcriptional repressor.  Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'.  Promotes HDAC1 binding to promoter regions.  Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B.  Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis.  May be a mediator of metastasis suppression in breast carcinoma.
What are the official names of this protein?
Breast cancer metastasis-suppressor 1.
What is the protein family that this protein belongs to?
Belongs to the BRMS1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly nuclear.
Protein: SPEE_SHIDS
Sequence: MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDLRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAVHTAAFALPQYLQDALAPQPS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NNRE_NEUCR
Sequence: MALKTLSAKAAAALDRELMSTGAFSIDQLMELAGLSVSQAVARVHPTKQGRRVLVAVGPGNNGGDGLVAARHLFHYGYQPAIYYPKRPKNDLYQRLVKQCEDLEIPFVDDFFAALESTDHVVDAIFGFSFSGEVREPFPAVINAMAETKVPVTSVDAPSSWDINEGPPKSGVGSNFHPNVLVSLTAPKPLVKYFKGRHFVGGRFVAPSIAKKYDFDVPKYEGIDQIVEITDNQVKI
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: RL9_PSELT
Sequence: MKVVLLKDIPGIGKTGDMKEVKDGYARNFLIPRGLAKMATEGEIKRIRNEKILKEHKEDLTKKKSEEILKTLQKQIHKVPAKVGGGGKLFGALTSTNLSEILSKNSGVEIDKKWINMDKPLKETGLYDIEMRLPGGVRGTIKVEIVGEEKG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RS11_SHEDO
Sequence: MAKVPSRSPRKRVRKQVADGMAHIHASFNNTIVTITDRQGNALSWATSGGSGFRGSRKSTPFAAQVAAERAGIAAQDYGLKNLEVFVKGPGPGRESAIRALNAVGYKITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: Y1843_MYCBO
Sequence: MITNLRRRTAMAAAGLGAALGLGILLVPTVDAHLANGSMSEVMMSEIAGLPIPPIIHYGAIAYAPSGASGKAWHQRTPARAEQVALEKCGDKTCKVVSRFTRCGAVAYNGSKYQGGTGLTRRAAEDDAVNRLEGGRIVNWACN
What are the official names of this protein?
Uncharacterized protein Mb1843c.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv1269c.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GH109_STRNV
Sequence: MNDAAPQNPGQDEAKGTGEKDNGGSMSPRSALRTTAGVAGAGLGLSALGTGTASASVPEAAQTAVPAAESDESAAPKRQGRTMAGVPFERRSTVRVGIIGLGNRGGSMIDLFLAVPGVRVVALCDTVRDKAASAAAKVVKAGQPAPAVYTKDEHDYEQLCARGDVDFVYVATPWDFHFEMAKTAMLNGKHVGVECPVAMRLDELWKLVDLSERTRRHCMQLENCAYGKNEMRVLRMAHAGLFGDLLHGAGAYNHDLRGLMFDPDYYEGPWRRLWHTRLRGDLYPNHGFGPVANYLDINRGDRAVSITSMGTPALGLAQYREENMPPGDASWKETYVSSDRTISLVQTAKGRVVRLEHDVSTPHPYSRINSLGGTRGVFEDYPERIYIEPDHANDEWGDFAAYADWDHWLWKEHANPPGGHGGMDYIMVFRLMQCVRLGLVPDFDVYDAATWTAPVPLSHASIKANGKPQQIPDFTRGEWKKSRPGTDSEKPSEP
What is the function of this protein?
Glycosidase.
What are the official names of this protein?
Glycosyl hydrolase family 109 protein.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.
Protein: RS10_BRUSI
Sequence: MNGQNIRIRLKAFDHRILDASTREIVSTAKRTGANVRGPIPLPTRIEKFTVNRSPHIDKKSREQFEMRTHKRLLDIVDPTPQTVDALMKLDLSAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: TPIS_YERPA
Sequence: MRHPLVMGNWKLNGSTHMVNELIAGLRKELSTVDGCGVAIAPPAIYLNQAKHELAGSRIALGAQNVDVNLSGAFTGETSAEMLKDIGAQYIIIGHSERRTYHQESDELIAKKFGVLKEIGLIPVLCIGESEAENEAGQTEAVCAKQLDAVLNTLGVKAFEGAVIAYEPIWAIGTGKSATPAQAQAVHKFIRDHIAKQDAAVAAQVIIQYGGSVNDKNAAELFTQPDIDGALVGGASLKADAFAVIVKAAAKAKKA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_FLAPJ
Sequence: METNRQKKIGGVIQKDLVDILQGEIRKNGISNLVISVSKVSVTTDLGVARVYLSVFPQEKAPEILESIKSNMYLIKHDLSQRVRLQLRKVPNLAFYIDDSLDYIEKIDNALAGKENPIENRDLLEKRKKI
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_LISW6
Sequence: MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGEVPKPQEIRHILSDYVIGQERAKKALAVAVYNHYKRINSNETKEEEVELSKSNICLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGNILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKEDETYLSRVVPEDLLKFGLIPEFIGRLPVIATLEQLDEAALVSILTEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERKTGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGEEEPQLQLEDGSIIPIKTSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: SPRTL_STAAM
Sequence: MNNDKLQRMVENLSEEKFGRTFRHCAYFNKRLRTTGGRYLLKSHDIEINPKQYEHYGEDAVVKIILHELCHYHLHIAGKGYQHKDQDFKRLSQQVGAPRFCNSIESYQQRANYEYYCTKCHAKYIRIRKVDTNRMRCGHCNGKLRMKRQLK
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NP04_VZVD
Sequence: MKNPQKLAITFLPLYVIPTYTLCIKALYKNTHAGLLFSFLGFVLNTPAMSISGPPTTFILYRLHGVRRVLHWTLPDHEQTLYAFTGGSRSMAVKTDARCDTMSGGMIVLQHTHTVTLLTIDCSTDFSSYAFTHRDFHLQDKPHATFAMPFMSWVGSDPTSQLYSNVGGVLSVITEDDLSMCISIVIYGLRVNRPDDQTTPTPTPHQYTSQRRQPETNCPSSPQPAFFTSDDDVLSLILRDAANA
What are the official names of this protein?
Nuclear protein UL4 homolog, ORF56 protein.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae HHV-1 UL4 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ALR_VIBPA
Sequence: MKAAKACIDLSALQHNLQRVKAQAPESKVMAVVKANGYGHGLRHVAKHANHADAFGVARIEEALQLRACGVVKPILLLEGFYSPGDLPVLVTNNIQTVVHCEEQLIALEQADLETPVVVWLKIDSGMHRLGVRPEQYDEFISRLKTCPNVAKPLRYMSHFGCADELDSSITPQQIELFMSLTSGCQGERSLAASAGLLAWPQSQLEWVRPGIIMYGVSPFSDKTAQDLGYQPVMTLKSHLIAVREVKQGESVGYGGIWTSERDTKVGVIAVGYGDGYPRSAPNGTPVWVNGRTVPIAGRVSMDMLTVDLGPDATDKVSDEAILWGKELPVEEVANHIGTIAYELVTKLTPRVEMEYTK
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: TRMN6_SALEP
Sequence: MSQSGSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVADVKRILDIGTGSGLLALMLAQRTDDNVPIDAVELDAGAAMQAQENVAHSPWPHRITVHTDDIQSWAPRQTVRFDLIISNPPYYEPGVECATPQREQARYTATLDHQTLLAIAADCITEDGFFCVVLPEQIGNAFTQQALNMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGSDQHYSESYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI_AGRRH
Sequence: MTLPANQSPEMVILCNELGEATGTAPKSEIHHSDTPLHLAFSVYIFNGDNKLLVTRRASDKITWPGVLSNSCCGHPQPGEPLTEAIERRVHEELRIRADDIRLVLPEFSYRASMTNGITENELCPVFAAHCKTSGVNPDLNEVSAWEWVHWQWFFESVQAERLLVSPWCRAQVDLLAPLGANPSQWPVAEERRLPKAARTKIDVQLKVS
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1961_STRT1
Sequence: MSHNHDHNHDHEVISLVDEQGNETLFEILLTIDGREEFGKNYVLLVPAGAEEDADGEIEIQAYSFTENEDGTEGDLQPIPEDSDAEWDMIEEVFNSFIDEN
What are the official names of this protein?
UPF0473 protein str1961.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: RRF_PSEP1
Sequence: MINDIKKDAQERMGKSIEALSRNLAAIRTGRAHPSILDSVKVTAWGSEMPLNQVAAITVEDARTLKIVAHDKNLSAAIEKAILTSDLGLNPSSAGTTIRVPMPALTEETRKGYTKQASGVAEDAKVAVRNVRRDALADLKKLTKDKEISEDEERRAADEIQKLTDKFVAEVDAAFKAKEKDLMAV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3168_MYCTO
Sequence: MANEPAIGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAPEVTVESGVDSTGMSSETIILTARWQQDGRSIQQKLVARVAPAAEDVPVFPTYRLDHQFEVIRLVGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVPPDVMPYTFGDNWFADAPAERQRQLQDATVAALATLHSIPNAQNTFSFLTQGRTSDTTLHRHFNWVRSWYDFAVEGIGRSPLLERTFEWLQSHWPDDAAAREPVLLWGDARVGNVLYRDFQPVAVLDWEMVALGPRELDVAWMIFAHRVFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSGVMWACVFMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH
What is the function of this protein?
Might catalyze the phosphorylation of aminoglycosides and confer aminoglycoside antibiotics resistance.
What are the official names of this protein?
Putative aminoglycoside phosphotransferase, Putative aminoglycoside antibiotics resistance enzyme.
What is the protein family that this protein belongs to?
Belongs to the aminoglycoside phosphotransferase family.
Protein: Y419_PSEMY
Sequence: MLKNALAALVLGSALIGGQAMAADYAIDKQGQHAFVNFKISHLGYSWLYGTFKDFDGKFSFDAANPEASKVSVTLNTASVDTNHAERDKHIRSADFLNVSKHGTATFESTSVKSTGEGTADITGDLTLNGVTKPVVIAAKFIGEGKDPWGGYRAGFEGTTTLKLKDFDITKDLGPASETVELILSIEGIRQ
What are the official names of this protein?
UPF0312 protein Pmen_0419.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: FIB37_BPM1
Sequence: VYITNAGDITLSPKGVEMAHVNNVRLYVHGERWTASQPGDWGSQWQVEAPIFVDHGYVSQDCYYPIIKGRSVITNQGFVTAVDLGIRRVNNNWGQAIIRVGSAEACPAAGHPNAVFEFHYDGTFYSPGNGHFNDVYIRSDGRLKINKKELENGALEKVCRLKVYTYDKVKSIKDRSVIKREVGIIAQDLEKELPEAVSKVEVDGSDVLTISNSAVNALLIKAIQEMSEEIKELKTPLFTKIARKISKYFKF
What is the function of this protein?
Structural component of the distal-half tail fiber.  It constitutes the part of the long tail fibers that recognizes the bacterial receptor.
What are the official names of this protein?
Long tail fiber protein p37, Protein Gp37, Receptor-recognizing protein.
What is the protein family that this protein belongs to?
Belongs to the tail fiber family.
What are the subcellular locations of this protein?
Virion.
Protein: LOLC1_EPIUN
Sequence: MTVDTITSTSNGNQDVPKEFFPKEFETQLLHVGRFPDILGSCAVPVYSSAAFEFNSVAHGARLLNLTQFGNIYSRFTNPTVNVLQNRLAGLEGGVAACAVASGSAAVVVTVMALAGVGDNFVSSFHVHAGTFHQFESLAKQMGIECRFVKSRDPADFAAAIDDKTKFVWLETISNPGNVILDLEAVSMVCHTKGIPLICDNTFGCAGYFCRPINHGVDIVVHSATKWIGGHGTTVGGVIVDGGTFDWGQHPDRFPQFHDPRTRLWERFSRRAFAVRCQFEILRDTGSTLSAPAAQQLLVGLESLAVRCERHAQNAAKIADWLREHPLVAWVSYVGHPNHPDHQGALKYLKRGFGSVICFGLRGGFEAGALFCDALKMVITTTNLGDAKTLILHPASTTHEHFSSEHRAEAGVTDDMIRLSVGIEQIKDIKADFEQAFEQVLRGKKSLRKPCIGKILLQDEINEDLFGPSACRT
What is the function of this protein?
Sulfhydrylase-like protein; part of the gene cluster that mediates the biosynthesis of loline alkaloids, potent insecticidal agents composed of a pyrrolizidine ring system and an uncommon ether bridge linking carbons 2 and 7 (PubMed:15654104).  Lolines are structurally differentiated by the various modifications of the L-amino group and include norloline, loline, N-methylloline, N-acetylloline, N-acetylnorloline, and N-formylloline (PubMed:15861432, PubMed:25531527).  The first committed step is the condensation of O-acetyl-L-homoserine (derived from L-aspartic acid) and L-proline, probably catalyzed by the gamma-type pyridoxal 5'-phosphate(PLP)-dependent enzyme lolC, to give the diamino diacid, NACPP (PubMed:15861432, PubMed:16755627).  Ensuing cyclization, decarboxylation, and acetylation steps yield 1-exo-acetamidopyrrolizidine (AcAP)(PubMed:24374065).  LolO is required for installation of the ether bridge upon the pathway intermediate, 1-exo-acetamidopyrrolizidine (AcAP) (PubMed:29537853).  In sequential 2-oxoglutarate- and O(2)-consuming steps, lolO removes hydrogens from C2 and C7 of AcAP to form both carbon-oxygen bonds in N-acetylnorloline (NANL), the precursor to all other lolines (PubMed:24374065, PubMed:29537853).  The enzymes lolD, lolE, lolF and lolT have also been proposed to be involved in the ether-bridge installation (PubMed:15654104).  Further processing of the exocyclic moiety of NANL by fungal N-acetamidase (LolN), methyltransferase (LolM), and cytochrome P450 (LolP) enzymes, with occasional involvement of a plant acetyltransferase, generates the other known lolines (PubMed:25531527, PubMed:18655839).  LolN transforms NANL to norlonine which is monomethylated and dimethylated to respectively lonine and N-methyllonine (NML) by lolM (PubMed:25531527).  LolP catalyzes hydroxylation of the methyl group in N-methylloline (NML) and further oxygenation to N-formylloline (NFL) (PubMed:18655839).  A plant acetyltransferase is responsible for the acetylation of loline to form N-acetylloline (NAL) (PubMed:25531527).  LolA might interact with aspartate kinase to prevent feedback inhibition of its activity by these end products and thereby promote production of L-homoserine from L-aspartate (PubMed:15654104).
What are the official names of this protein?
Sulfhydrylase-like protein lolC1, Loline biosynthesis cluster 1 protein C.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
Protein: SYH_BRUA1
Sequence: MADKADKMKARLPRGFVDRVPDDLRAAEKMMATIREVYDLYGFEPVETPLVEYTDALGKFLPDQDRPNEGVFSFQDDDEQWLSLRYDLTAPLARYVAENFETLPKPYRSYRNGWVFRNEKPGPGRFRQFMQFDADTVGAPNVSADAEMCMMMADTLERLGIQRGDYAIRVNNRKVLDGVLDAIGLEGEGNAAKRLNVLRAIDKLDKFGPEGVRLLLGKGRLDESGDFTKGAQLPEAAIEKVLAFTAAGGADGAQTIANLQAVVAGNAKGEEGVQELADMQALFFAGGYEGRVKIDPSVVRGLEYYTGPVFEAELLFDVTNEDGQKVVFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSRLMTALKNLGKLDVSDTVGPVVVLVMDKDTQNLGRYQKMVSDLRKAGIRAEMYVGGSGMKAQMKYADRRAAPCVVIQGSQEREAGEVQIKDLVEGKRLSAEIEDNVTWLESRPAQITVREDGLVDAVREILDAQARDRAEQSK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPT1A_RAT
Sequence: MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFIRFKNGIITGVFPANPSSWLIVVVGVISSMHAKVDPSLGMIAKISRTLDTTGRMSSQTKNIVSGVLFGTGLWVAVIMTMRYSLKVLLSYHGWMFAEHGKMSRSTKIWMAMVKVLSGRKPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEEDFQRMTALAQDFAVNLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMEMLYITPTHIQAARAGNTIHAILLYRRTLDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHIKDSRHIVVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDPSEPQPGEAKLAALTAADRVPWAKCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFDRWFDKSITFVVFKNSKIGINAEHSWADAPVVGHLWEYVMATDVFQLGYSEDGHCKGDTNPNIPKPTRLQWDIPGECQEVIDASLSSASLLANDVDLHSFPFDSFGKGLIKKCRTSPDAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTMESCNFVQAMMDPKSTAEQRLKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPWRLSTSQTPQQQVELFDFEKNPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKFSSPETDSHRFGKHLRQAMMDIITLFGLTINSKK
What is the function of this protein?
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:16908527, PubMed:21990363).  Plays an important role in hepatic triglyceride metabolism (PubMed:18349115).
What are the official names of this protein?
Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, Carnitine O-palmitoyltransferase I, liver isoform, CPT I, CPTI-L, Carnitine palmitoyltransferase 1A.
What is the protein family that this protein belongs to?
Belongs to the carnitine/choline acetyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: SIXC_ODODO
Sequence: QSTGGKAPECLLSNYCNNECTKVHYADKGYCCLLSCYCFGLSDDKKVLEISDSRKKYCDYTIIN
What is the function of this protein?
Excitatory insect beta-toxins induce a spastic paralysis (PubMed:32442468).  They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity).  In vivo, this recombinant protein is lethal to Locusta migratoria larvae after injection, but has no significant effect when orally administered.  Is not toxic to mice after intracerebroventricular injection (PubMed:32442468).
What are the official names of this protein?
Beta-insect excitatory toxin OdTx12, Sodium channel toxin NaTx12.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: THIC_SHEDO
Sequence: MSSRRETRASAQTFIENLKPLQHPNSEKVFLSGSRPDLRVGMRQIHQTDTLHAKTNGETLREQNPPIMVYDCAGAYSDPNADINVHAGLEKFRQSWIEERQDTELLKGVSSQFTQQRLADDGLDHLRFDALVKPRRAKAGRCVTQMHYARRGIITPEMEYIAIRENMAREHVPEGVLTQKSAGESFGACIGEPITAEFVRSEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWIIRNSPVPIGTVPIYQALEKVNGVAEDLNWEVFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKESFLYEHFREICELCAAYDVSLSLGDGMRPGCIADANDEAQFAELETLGELVKIAWEYDVQTIIEGPGHVPMHLIKVNMEKQLEHCDEAPFYTLGPQTTDIAPGYDHFTSGIGAAQMAWYGCAMLCYVTPKEHLGLPNKEDVKQGLIAYKIAAHAADIAKGHPGAQVRDNALSKARFEFRWEDQYNLGLDPDTARAYHDESLPQESAKVAHFCSMCGPKFCSMKITQEVREYAADQEAKALLAQAPLAQANIQDVELISPDEYKARQATEADLAKAMAQKSAEFKSQGSALYHSIDSSGINDNKNDQQDASVVRVPSLEIEG
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.