PharMolix/UniProtQA huggingface dataset:
Protein: HPM2_HYPSB
Sequence: MVIKLYGSAMSTARVLVTLLEKELPYEHILVDISKGDQNKEEYLKLQPFGKVPVLDDNGFIMYESRAICRYLARKYDSGTKLIPDVDDHEAYGRFEQGCSIEYSYFAAAAETLGTELVIKKYKGLGEPDMTRVAQAEADFDKVFFEYDKILAKQKYLTGDEISLVDLFHLPNASALKAFGYQGTFEKYPNVNRWFSGLQARETWIKATAEAR
What is the function of this protein?
Glutathione S-transferase; part of the gene cluster that mediates the biosynthesis of hypothemycin, a resorcylic acid lactone (RAL) that irreversibly inhibits a subset of protein kinases with a conserved cysteine in the ATP binding site such as human ERK2 (PubMed:18567690).  The first step is performed by both PKSs hmp3 and hmp8 and leads to the production of 7',8'-dehydrozearalenol (DHZ) (PubMed:18567690, PubMed:20222707).  The highly reducing PKS hpm8 synthesizes the reduced hexaketide (7S,11S,2E,8E)-7,11-dihydroxy-dodeca-2,8-dienoate, which is transferred downstream to the non-reducing PKS hpm3 (PubMed:20222707).  Hpm3 then extends the reduced hexaketide to a nonaketide, after which regioselective cyclization and macrolactonization affords DHZ (PubMed:20222707).  The next step is the conversion of DHZ into aigialomycin C and is performed by the O-methyltransferase hmp5, the FAD-binding monooxygenase hmp7, and the cytochrome P450 monooxygenase hmp1 (PubMed:18567690).  The wide substrate tolerance of the hmp5 and hmp7 implies that the reactions from DHZ to aigialomycin C can occur in any order (PubMed:18567690).  The steps from aigialomycin C to hypothemycin are less well established (PubMed:18567690).  The FAD-linked oxidoreductase hmp9 presumably catalyzes oxidation of the C-6' hydroxyl to a ketone (PubMed:18567690).  The timing of this oxidation is important, since the resulting enone functional group is a Michael acceptor that can react spontaneously with glutathione, an abundant metabolite in fungal cells (PubMed:18567690).  The glutathione S-transferase hmp2 catalyzes cis-trans isomerization of the 7',8' double bond with equilibrium favoring the trans isomer (PubMed:18567690).  The hpm6-encoded transporter might preferentially pump hypothemycin out of the cell relative to the trans isomer aigialomycin A.  The cis-to-trans isomerization may be coupled with C-4' hydroxylation, since all known hypothemycin analogs containing the enone functional group also have hydroxyl groups at both C-4' and C-5' (PubMed:18567690).
What are the official names of this protein?
Glutathione S-transferase hmp2, Hypothemycin biosynthesis cluster protein hpm2.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
Protein: EX7L_VIBCH
Sequence: MSSSLANRNIYTVSRLNSEVRLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSQAQVKCAMFKGNNRLVNFKPQNGQQVLVKARLSLYEPRGDYQIILESMQPEGDGRLQQQFEQLKMQLAAEGLFAQTRKKPLPENPRCVGIITSRTGAALHDILHVLKRRDPNLPVVIYPTLVQGEEAAIQIAQAIGRANTRAECDVLIVGRGGGSLEDLWCFNHEIVARTIAASEIPIISAVGHEIDVTIADFVADVRAPTPSAAAELVSRDHRHKQQALHQWQAKLASTMRHYLAQQETQFARLQHKLDKQHPQARLERQQQQLDELSLRLEQKMQQRLATQQQRWDRLSHKIELHSPIHLIRQQRFNLIQQEQRINQSIQRYLIQSRHQLALLSEKLDAVSPLATLARGYSVTRTTQGELVRQSAQVKPGDTLVTQLMDGEILSTVNSR
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWE1_CANAL
Sequence: MDSNPCQDVSGDTSSTPMANNNPTNDSTISSQNHSKIGLRKHQQQHYHQHSHSQMHSHSQQSPYINQLEYFTNNQFSRSFNSLILEDANDANTNNSSTTTLNKKTINKSPPFNIKQDLLNDSIDTFLDNSNTETIEDGDVTTTDDDHDFDDEDIEDPEAVQYTPTLNILKSKKVDSFDIISSKHRKSNSQITYNSHVRKPSEEDTSSSMATIRLSNNSQSSIKRSSKYLNLSIDSNLKTVDGGKIPDEIDDISLNEIDVAVAPNDFSSPLSARKPDIFAAITAANGNSNNQFKRPHKLVSQSPSPSSKNKFRISSSTTSSPQSNLHSPSKLGSKGFKMFKNANRDAIMSSSRVMTPEKPKMVSKIFGKSAKIRRAYTPTHTSTPMAVSSLNPPSSSTSNSTTAAITSTSPPANEHYDIDNDFDSPSKNRKSSNISASSIIIYQDENHIKSNHARKSSNPIPYPPTEPLPTNISASVAETGKGSTTTKSNLSKGCPLFDDKENKASYQFVKPLQTAFNSSGLVKKNSISGSSDRKLPPETPIKRNPLMILNTNKVVPPYSSGFAEGKDVMGDQHDIYSHIPCQNQRFPGSVNPNTTTNNNNTQQHHDSDLSIEVGRNNSYDASSSTINNTSYIKIFPSSELKKEQVLQRPQEDLELVFNSDIELDDNIIPETPTKKSLLPNQHHQHHLPLYTQSKSPLLKFDTEKDGRRNLSIVLDKSNATKREISEPPSTPINMSFAKNSFKKPMNNAERGDDPDSIIAQRIDIMPSLDEADSVSVYPSKIDEHLIEKFGMKNIKYIGSGAFSIAFECLFNNEKFAIKRTKKPLIGKLEKQTIKREIEALRVLTSIKEDEATNMQEQEEGKEYLVYFIEAWDFNNYYYIMTEFCEGGTLFDFLEENKHYKIDEFRIWKILIEILNGLKFIHSKNYLHLDLKPANIFITFEGSLKIGDFGLATKLPILEKDFDLEGDRNYIAPELINDKIYTPFADIFSLGLIILEIAANIILPDNGTPWRKLRSGDLSDAGRLSSDNISMFLQHNPNTNSNISGSGSRSGSGSTGGNGSAGDGSTNSTNFSYNSLSGNSLTLNPPVKAVHGTSDTNNTLASELSKNIEGLIPSWAPDFLVHGDSMNLDKLVNKMLRPNPFDRPSACNILEMPECLIVENRRKCGATIFEGEFGSPPDE
What is the function of this protein?
Protein kinase that acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylating and inhibiting the mitosis-promoting cyclin B-bound CDC28 at 'Tyr-18'.  SWE1-mediated inhibition of CDC28 acts in a cell size or morphogenesis checkpoint to delay mitosis in response to defects in growth, actin organization or bud formation.  Plays an important role in filamentous growth.
What are the official names of this protein?
Mitosis inhibitor protein kinase SWE1, Wee1 homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
What are the subcellular locations of this protein?
Bud neck. Nucleus.
Protein: GATY_ECO45
Sequence: MYVVSTKQMLNNARRGGYAVPAFNIHNLETMQVVVETAASMHAPVIIAGTPGTFTHAGTENLMALVSAMAKQYHHPLAIHLDHHTKFDDIAQKVRSGVRSVMIDASHLPFAQNISRVKEVVDFCHRFDVSVEAELGQLGGQEDDVQVNEADAFYTNPVQAREFAEATGIDSLAVAIGTAHGMYASAPALDFSRLENIRQWVNLPLVLHGASGLSTKDIQQTIKLGICKINVATELKNAFSQALKNYLTEYPEATDPRDYLQSAKSAMRDVVSKVIADCGCEGRA
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires GatZ subunit for full activity and stability.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.
Protein: SRP54_ASPNG
Sequence: MVLQDLGRRINAAVNDLTRSNNLDEKQAFDDMIKEICAALLSADVNVRLVQSLRKSIKSSVNFASLPPAVNKKRLIQKAVFDELVSLVDPHAEPFRPKKGRSNVIMFVGLQGAGKTTTCTKLARHYQMRGFKTALVCADTFRAGAFDQLKQNATKAKIPYYGSLTQTDPAIVAAEGVAKFKKERFEIIIVDTSGRHKQEEELFTEMTQIQTAVTPDQTILVLDSTIGQAAEAQSSAFKATADFGAIIITKTDGHAAGGGAISAVAATHTPIIYLGTGEHLMDLERFEPKAFIQKLLGMGDMAGLVEHVQAVTKDSASAKETYKHISEGIYTLRDFRENITSIMKMGPLSKLSGMIPGLSNLTAGLDDEDGSMKLRRMIYIFDSMTAAELDGDGKMFVEQPSRMVRIACGSGTTVREVEDLLSQHRMMAGMAKRVGGQKKQMQRAQNMLKGGNKEQQLAAMQKRMAAMGGAGGGGFPGMPGMGDMAKMMQMLQGQGGGGGGGLPGLGGMDLQSMMSQMSGLMGGGGGGGGRGRGR
What is the function of this protein?
Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane.  SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences.  It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting.  srpA/srp54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes.  srpA/srp54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit srp101.  Both, srpA/srp54 and srp101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon).  After signal sequence transfer, srpA/srp54 and srp101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.
What are the official names of this protein?
Signal recognition particle subunit SRP54, Signal recognition particle 54 kDa protein homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRLE_DICDI
Sequence: MGKKKIDINTREDLFLSYYKEIEKNKFDLLKICSDKNFSKSNFLKAVHCLFSLSYFCKIKDENEEEEGKEEEINDYKVKKSTTGNYYRNSEGKLFKKSNEKDQIDDVSIFYKRLPTIQDFKDTYDKYENCLNSVYYIIRKIKLLHLEYFWEILASCYGTISFIKFFNIFSNEIFSPSENGDSVFIMVGKFFRRKVRAETHYDLIFLKIILANASIPMILKLGVKDIGRFTEKEDIIVSYYRNFSIIHSLRFDNVKEFALVYKTLKNNYPSKKKKKITLFEENGKINVKTSKKDLMLFEFVCKFDCVKIFKKYFLPKPQIINNNDNNEMLECISSGSYSGFDEKSKRKIRIFFSICCRQISPKILKCIVDYVKDDIGFLDLQNRQDIYIGDSAPEKVLFLNCFFGNHKEQRVIDFFNLLTSKSIIICNTIKEKPELYDYRYITLSTVDSTFYFSDSHKGADFGVYTDEINVIINNDDIDYDYIGDDDNDEEIEETKDYGSSSSDIDDFYNVFEPKASMIPNILDSCSLEILKAYIQNITGNGLFKISPSLFLAHDVTRLVRNPKPKTETVVKILEFINTISRLSELSTNGVPFTFLTNRFEIVTSIIMSLHDERSISNSVEPVQWLRALAPFVSNDEMKLIIYKVRTLYNYEPHSNGEIKYTELVRLFDVQYLLTKGKFSLSQFNGFETSIFLNPKLLDGTINSNILNSMIIKDKEKLDLKELFFKEKPLSEAELKEKFEIATKNEKELLDQLKKENDAEKLKKKNKLKKQKNQQQQQQAKQQAQQQKQQHQQNIQQNYENQHIEDQRKFNQQTKGRPISPSSIQNQNLNPTLLQNQNQTSNPTPNLESTKKATPTTTTTTTTNSNTSAIINEIKNQDLNQQQNITENINEIYDVSIGKFKFNKKESNILGRGSNGTLVFKGIWNNRIPVAIKQMQKMFNPLISKEIEILIGLTNKNLNLVGYIDQEEDENCVYLGLTLCDGSLQSLYDQSKLNEFINQNNNQNNNNNNNRVLDLIIGMINGVIFLHDQNIVHNDLNPRNILVKDNRLIISDLGLSKMNVSSTYNFSTNAIPTGQDGYHPVEVLLEKRKTKSVDVFSLGCLIYFIMTNGAHPFGDKFSRLRYITKSKYNLSQLSNLNLVATHLIELMISYDESKRPTLSSVLKHPLFWDSLKKIKFLESSLRLLGDHDFKKFNINKILISCNSNSSSSNSICNSSNSSSSSSSSISSSSCKISSSSCYCVPLPWNQSLDYQLVDSLSNQIEKKVASYKFDQLHDLIRFIRNTLQHYNQIYRDLKQILPNSDILESLKSQQSALNYFESKFPTLIIFLFNHFSAIPEIKNSIHFSNDTCSIF
What are the official names of this protein?
Probable serine/threonine-protein kinase irlE, Inositol-requiring protein-like protein kinase E.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ACE1_CAEEL
Sequence: MRNSLLFFIFLPSTILAVDLIHLHDGSPLFGEEVLSQTGKPLTRFQGIPFAEPPVGNLRFKKPKPKQPWRIPLNATTPPNSCIQSEDTYFGDFYGSTMWNANTKLSEDCLYLNVYVPGKVDPNKKLAVMVWVYGGGFWSGTATLDVYDGRILTVEENVILVAMNYRVSIFGFLYMNRPEAPGNMGMWDQLLAMKWVHKNIDLFGGDLSRITLFGESAGAASVSIHMLSPKSAPYFHRAIIQSGSATSPWAIEPRDVALARAVILYNAMKCGNMSLINPDYDRILDCFQRADADALRENEWAPVREFGDFPWVPVVDGDFLLENAQTSLKQGNFKKTQLLAGSNRDESIYFLTYQLPDIFPVADFFTKTDFIKDRQLWIKGVKDLLPRQILKCQLTLAAVLHEYEPQDLPVTPRDWINAMDKMLGDYHFTCSVNEMALAHTKHGGDTYYYYFTHRASQQTWPEWMGVLHGYEINFIFGEPLNQKRFNYTDEERELSNRFMRYWANFAKTGDPNKNEDGSFTQDVWPKYNSVSMEYMNMTVESSYPSMKRIGHGPRRKECAFWKAYLPNLMAAVADVGDPYLVWKQQMDKWQNEYITDWQYHFEQYKRYQTYRQSDSETCGG
What is the function of this protein?
Rapidly hydrolyzes acetylcholine and releases choline into the synapse (Probable).  It can hydrolyze propionylcholine and butyrylthiocholine in vitro (Probable).
What are the official names of this protein?
Acetylcholinesterase 1, ACE-1, AChE 1.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Synapse. Secreted. Cell membrane; Peripheral membrane protein. Note=May be secreted or membrane associated via a non-catalytic subunit.
Protein: LIAS_ORYSI
Sequence: MHGRRHLAASLARALTYAPSRSISSTPSLLQTLDPSTPSPAAAPPTAGRLAELRQRLQADAPSLGDFTYSVEVGTRKKPLPKPKWMKETIPGGAKYAGIKAKLRELKLHTVCEEARCPNLGECWSGGETGTATATIMILGDTCTRGCRFCNVKTSRTPPPPDPDEPSNVAQAIASWGLEYIVITSVDRDDLPDQGSGHFAETVQKLKVLKPEMLIEALVPDFRGDPACVEKVATSGLHVFAHNIETVEELQRNVRDHRANFKQSIDVLKLAKEYAPAGTLTKTSIMLGCGETPDQVISTMEKVRAAGVDVMTFGQYMRPSKRHMPVSEYVTPEAFERYRSLGVDMGFRYVASGPMVRSSYKAGEFYIKAMIEADRAKATTAI
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MED14_CANGA
Sequence: MNGTRAAPGVTPSEVAMNGKNEMEVVEQAPIPKTNANIGLKSPVNTVEDVNQEDSTNSPPPIPHVEINQMPLSMIIRNLTVYTVKEISQYMKTTVHMNTADTSTARKMRFLNLLIFIRNQFLKLYVLIKWCRTIKENNFNIMIDLLNWFRGTNMTVNNCIWALKSTLESTTNAKLPNVDLVTALEVLTLGRPNLPTHDFKLSGENNEYETVNGQLRIPTKLIMQRLKDLNIIVMIKISSIDIPKQFNNYEIRDGRVYITVPGEFEIQLSTIDRHSPFFFVDFKLLFAGTDSLFNKPRLEKIINDVLLRNKKPLYSLYSLLHRYVLTLQLYMIHLELLNLENDGKFSGGNLVHSYNAKKSLIVMKYWRNGKLGNKTKIIIGVDRKSEDLVLKWDNENAKQSMHMPLVYTHVVGNVEAILDEIMFNHSRLIRADLLSRGVFQEDEEDPSVLLFQLPTTCLSTAPIQLKIDLVSGVFYFKNPSPLLLEYVSQINRAETPEDLTSVLQRLKLDKIVHIIRNMFDKTGWVCSKVIKLDNPIATSVNSEEIKTNLLQNDMFIRLASWPVNWYLILTIVSSNSSCIIEKRIGKIISTSGKWKVQYLDTTNVLSLKLESITYKKIISLQKSTLNRIINHTLIDSLNHLKTRNKVCSPDLIVNSLPKHLLEDEVDDKVPHSIENYHHISLITIELESFLEGSKALSGILESTMFLRMDYKKFEIRLYGKFKRSTMAFHCQCDDLLINFVEREPLAFYLAETFTNLNEIVQYLTLFRQKLMQLVVLTDVVERLHKNFASDHFKIISLKPNEVTFKYLKSSTDDKDCTINIITNEQTIKNLTVKLSDKNPQHIIQPFIDNQQFEYQFIFSYLQFTSPLFCCLKEILDESNKEERLENAKEESDSTRTSTSITLGLHNLSEYQLVYFNPELGYKITLILELKEVSINGKKKIQFYVHFSQDEHITTKSSAYPLIHQVRNEIFMLEMKKRDGTPSLIKLDNTRNVIRLGNGISCDSDSIVEVLMSINKILLGDSKSAPQITTVPPTNKTI
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 14, Mediator complex subunit 14.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPP_STAAT
Sequence: MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLI_METVS
Sequence: MLFNEFCKIIEKIENTPKRLEKIDYFVEIIDFVKNHGKPENLKEICQVSIGRVFAEYENREIGIGPNLLIEAIKTTGISENDLNLKIKETGDIGISVEHLSSKIKQISLFNEPLTFEEVYSTIKKLSTIEGTSSQKKKIRIISNLLIIANPIESRYISRLILEDMRIGMNIPTILAAFSNYFGIEKEKIEKVYAVTNDIGLIGKKLLENSNFEEDPELNLTVFRPIKPMLAQLTPSIEEAVIEMKNPQFETKYDGARVQVHKSNGEVKIYSRRLEDITNSVPELVLEIKNLEVDNVILEGECVAMNLENGKPRPFQDILRRFRRKYDIDKMTEEVSLRIYFFDILYHNKGLIDLPLFERRNILENIFGTNNWDLELKKIENEIKSNKMLFTSFKVSSTDLKIAKEFFKWSLSIGHEGIMVKNLNAIYTPGSRVKTMCKIKQTLENLDVVVTRAKIGMGKRKDWYGSYEISVKGDDESLHVIGNVGSGLTEEDLEKLTKIANEIKIEDLGGEVILEPKIVLEVTYEEIQTSEKYEMGYALRFPRVVGIREDKSINDINSLDDVKKIYEIERKRK
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: ITP_HHV2H
Sequence: MSDSALQVPAPAGMTPPSAPPPNGPLQVLLGSLTNLRRPPSPSSEPAGSADEPAFLSAAKLHAATAAFLLSGAAVGPAEARACWHPLLEQLCALHRAHGLPETALLAENLPGLLVHRMAVALPETPEAAFREMDVIKDTVLAITGSDTTHALEAAGLRTTAALGPVRVRQCAVEWIDRWRTVTQSCLAMNPRTSLEALGEMSLKMSPVPLGQPGANLTTPAYSLLFPSPIVQEGLRFLALVSNWVTLFSAHLQRIDDAALTPLTRALFTLALVDDYLTTPDRGAVVPPPLLAQFQHTVREIDPAIMIPPLEATKMVRSREEVRVSTALSRVSPRSACAPPGTLMARVRTDAAVFDPDVPFLSASALAIFRPAVTGLLQLGEPPSAGAQQRLLALLQQTWALVQNSNSPSVVINTLTDAGFTPAHCTQYISALEGFLVAGVPARTPPGHGLSEIQQLFGCIALAGANVFGLAREYGHYAGYVKTFRRIQGASEHTHGRLCEAVGLSGGVLSQTLARIMGPAVPTEHLASLRRTLVGEFETAERRFSAGQPSLLRETALIWLDVYGQTHWDLTPTTPATPLSALLPVGPPSHAPSVHLAAATKIRFPALEGIHPNVLADPGFVPYVLALVVGDALRATCNAAYLPRPIEFALRVLAWARDFGLGYLPTVEGHRTKLGALITLLEPATRAGVGPTMQMADNIEQLLRELYVIARGAVEQLRPAVQLPPPQPPEVGSSLLLISMYALAARGVLQELAERADPLVRQLEDAIVLLRLHMRTLAAFFECRFESDGHRLYAVVADAHERLGPWRPEAMGDAVSQYCGMYHDAKRALVASLAGLRSVVTETTAHLGVCDELAAQVSHEGNVLAVVRREIHGFLAIVSGIHARASKLMSGDQVPGFCYMSQFLARWRRLSAGYQAARAATGPERVAEFVQELHDTWKGLQTERALVVARFASSADQRTAAIQEVMAHATEDAPPSPAADLVVLTNRHDLGAWGDYSLGPLGQPTVVPDSVDLSPQGLAATLSMDWLLINELLQVTDGVFRASAFRPSAGPGAPGDLEAQDAGGSTPEPTTPGPQDTQARAPSTRPAGRETVPWPNTPVEDDEMTPQETPPVHP
What is the function of this protein?
Plays an essential role in cytoplasmic secondary envelopment during viral egress.  Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs.  Modulates tegumentation and capsid accumulation at the viral assembly complex.
What are the official names of this protein?
Inner tegument protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae inner tegument protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus, host trans-Golgi network.
Protein: NUOD_THEM4
Sequence: MGEVKLFFGPNHPGMHGNFSVHMYVEGDTVVKARPLPGFLHRGFEKLMERRLWYQNLALIPRICVPEPDINELCYALAVEKIAKIDVPERAQWIRMIVLELARIANHLWSFSGIGGPIGLYTGSFWGTADRDRILDIFENLTGARVYHMYIVPGGVRKDLTPKIEKMILETLDYIESRLPDYEKLILKNRIVHTRLKGIAKLDRETALEMGVTGVGLRATGVPYDIRKVDPYLFYDKVDFEVPFSTDGDAFARVYLKFREIFQSIKIVKQALEKMPVGKVNTPISEGSALRFRVPKGQAYVHIESTRGEYGYYMVSDGGEKPYRVVVRGASYPQTFIGVEKYLPGTRIEDVPIWLSTMDVCAPEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL13_METBU
Sequence: MTVIDANGLIMGRLASNVAKMLLSGEEVSIVNAERAVISGSKVTTFEEYDVIRNMGTREFGPYFPRRPDRILKRTVRGMLPYKRARGKDAMGRLKVYVGIPYEYQDAEFVSVEGAEMTRLSSNKYVTIGDVSRQLGSKF
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: YCCT_SALTY
Sequence: MKTGALATFLALCLPVTVFATTLRLSNEVDLLVLDGKKVSSSLLRGAESIELENGPHQLVFRVEKTIRLPGNEERLYISPPLVISFDTQLISQVNFQLPRLENEREASHFNAAPRLALLDGDAMPIPVKLDILAITSTAKVVDYEIETERYNKSAKRASLPQFATMMADDSTLLSDVSELDTVPPQSQTLTEQRLKYWFRLADPQTRHHFLQWAEKQPPS
What are the official names of this protein?
UPF0319 protein YccT.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: SSPI_BACCR
Sequence: MSFNLRGAVLANVSGNSQDQLQETIVDAIQSGEEKMLPGLGVLFEVIWKNADENEKHEMLETLEQGLKK
What are the official names of this protein?
Small, acid-soluble spore protein I, SASP I.
What is the protein family that this protein belongs to?
Belongs to the SspI family.
What are the subcellular locations of this protein?
Spore core.
Protein: 3L21_OXYSC
Sequence: MKTLLLTLVVVTIVCLDLGYTRRCFTTPSVRSERCPPGQEVCYTKTWTDGHGGSRGKRVDLGCAATCPTPKKKDIKIICCSTDNCNTFPKWP
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Long neurotoxin 1, LNTX-1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CAPP_PROMP
Sequence: MESMKQFKNNNVDLISNNDPLDKNRALIEDLWESVLREECPDDQANRLIQLKELSYSNKVEEYSPKNFKTEIVDIVNSMDLAESISAARAFSLYFQLVNILEQRVEEDRYIQSFTNQNVKKSHDNLDPFAPALARQNAPVTFKELFFRLRRLNVPPGKLEELLQEMDIRLVFTAHPTEIVRHTIRHKQTRVANLLQKIQVEKFLTIEDIKSLKIQLKEEIRLWWRTDELHQFKPSVIDEVDYALHYFQQVLFDAMPQLRGRISSALTENYPDVQMPTESFCTFGSWVGSDRDGNPSVTPEITWRTACYQRQLMLERYIKATSNLRDQLSVSMQWSQVSSSLLESLETDRVKFPEIYEARATRYRSEPYRLKLSYILEKLRLTHERNNLLSEGGWKLSLERESDNKNLELVEKLHYKSVDEFTYDLELIKNSLNSTDLTCEAVNKLLTQVHIFGFSLASLDIRQESTRHSDAIQELTNYLELPKQYDQMSEKDRIQWLNEELNTKRPLIPSEVNWNKSTEETFSVFKMVKRLQEEFGSRICHSYVISMSHSASDLLEVLLLAKEMGLIDQGSQKSTLLVVPLFETVEDLQRAPDVMEQLFQLDFYKSLLPKVGESFKPLQELMLGYSDSNKDSGFLSSNWEIHRAQIALQNLSSRNNILLRLFHGRGGSVGRGGGPAYQAILAQPSGTLKGRIKITEQGEVLASKYSLPELALYNLETVTTAVIQNSLVNNRLDATPEWNDLMTRLAETSRIQYRKLVHENPNLLTFFQEVTPIEEISKLQISSRPARRKKGAKDLSSLRAIPWVFGWTQSRFLLPSWFGVGTALSVELKSDPEQIELLRVLHQRWPFFRMLISKVEMTLSKVDLEVAKYYVDTLGSKENSKSFEEIFDVISKEYNLTKSLVLEITGKNKLLESDRDLRSSVNLRNKTIIPLGFLQVSLLRRLRDQTRQPPISEFIEDRIESKRAYSRSELLRGALLTINGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: PUR5_BURM1
Sequence: MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVVKGIAQGCELSGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLALMQKIAVKGMAHITGGGLVENIPRVLREGLTAELDQKAWPLPPLFKWLQEHGGVADAEMHRVFNCGIGMAVIVSAADADAAVSDLTAAGEQVWKIGTVRASREGEAQTVVV
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CITG1_SALTY
Sequence: MNVSVVTERRTPAYSSLAAGELNGLVARALLTEARLTPKPGLVDIRNSGAHRDMDLAAFERSTTAIAPWMEKFFIMGNNTAALAAENVLVMLRPLGMACENDMLQATNGVNTHRGAIFAFGLLSAAIGRLLARGEPLEQNRICDQVARLSRNIVAHELSAKKAGKLTKSETHFQCYGLSGARGEAESGFRTVRTQALPVFNRVVQEHDDTHLALLQTLLHLMAWNDDTNLVSRGGLEGLYYVQQQAQKLLWQGGVLVEGGIEAMQSLDDELILRNLSPGGSADLLAVTWFLSHFPAGSLYPE
What are the official names of this protein?
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase 1, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase 1.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: ASR_SHIFL
Sequence: MKKVLALVVAAAMGLSSAAFAAETATTPAPTATTTKAAPAKTTHHKKQHKAAPAQKAQAAKKHHKNTKAEQKAPEQKAQAAKKHAGKHGHQQPAKPAAQPAA
What is the function of this protein?
Required for growth and/or survival at acidic conditions.
What are the official names of this protein?
Acid shock protein.
What is the protein family that this protein belongs to?
Belongs to the Asr family.
What are the subcellular locations of this protein?
Periplasm.