PharMolix/UniProtQA huggingface dataset:
Protein: DAPD_YERPB
Sequence: MQQLQNVIETAFERRADITPANVDTVTREAITHVIDLLDTGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVMEGAETRYYDKVPMKFAGYDEARFQHEGFRVVPPATVRKGAFIARNTVLMPSYVNIGAFVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFVGARSEVVEGVIVEEGSVISMGVFIGQSTRIYDRETGEVHYGRVPAGSVVVSGNLPSKDGSYSLYCAVIVKKVDAKTRSKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCP_GEOSL
Sequence: MGMFCNQCEQAAKGVGCEIMGVCGKNPEVAALQDLMLYGLKGLAIYADKARELGARDEAIDLFMIEGLFTTVTNVDFDPVSLAGKLRTCYDMKEKAKSLYETAYREKNGGHAPAIAAGPAAWVIASDLEGLVKQGLEHGINTHHTDADVRSAIEILIYGLKGMAAYADHAYILGKKDEEVFAFFHKAMAATADPAKGLMDFVGLSMECGKLNIKVMGMLNEGHVDHYGHPVPTKVPTGTRRNKGILVSGHDLRMLEELLKQTAGKGIDIYTHGEMLPAHGYPGLKQKYPHLYGNFGGAWQDQAKEFPLFPGAIIFNTNCIQRPADSYKDRLFSWGQVGWPGVKHISGWDFSEVINKALECPELADAPEKEILTGFGHNAVLGVADKVIEGVKAGAIKHFFLIGGCDGAKPGRNYYTELAEKVPQDCVILTLACGKYRFNKLEFGDIGGIPRLLDIGQCNDAYSALQIALALANAFNCGVNDLPLSMILSWYEQKAVVILLSLLHLGIRNIKIGPSLPAFVTPNVLNFLVENFNLGPITTVEADLKAALGQ
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLYB1_POLPI
Sequence: SADIVKKLWDNPAL
What is the function of this protein?
Venom component which lacks hemolytic or antibiotic properties, but produces an inflammatory response via mast cell degranulation and produces a chemotactic effect on leukocytes.
What are the official names of this protein?
Polybine-1, Polybine-I.
What are the subcellular locations of this protein?
Secreted.
Protein: ROK1_ASPNC
Sequence: MDAFKLLTRSTKFKAGNSLSSTLPSKGKAENPQLFRDAEAEKLLESNAFGKKRKRTQAAGDSDAEDGNAGDLDFFGSGKRSAASAPSKKDEDGPSEQKDASDSEGDDSMDEVERRTILNSHKIKVTDMRDFEELQPTQPQKEESKKKKKKRKQQEEEPAQTLTKKEQKKARRLFPEPLVSFKQLRTKYNISRRLAENIAEQGFTVPTEVQLGSLPLLLGDQSVPQKSGTEKSTEPDLLVVAPTGSGKTLSFMIPVINKIVRHHHEKPEERGILSVVIAPTKELASQIVNEGRKLALGTGVKITLMKKGMRVVERDDEDDSKDVLDEDDSESLGSEDDEKATAKNSKGKAPVTKSDILVTTPLLLVNALSANRTKPLATLPLVRNVVLDEADVLLDPLFRDQTLDIWRSCTHPELRASLWSATMGSNVEDLAKSTIKERKDTLSETKSYPLLRLVVGLKDSAIPNIKHKLVYAATEQGKLLGLRQLLHPAAASSTDIRLRPPFLIFTQTIPRAVALHSELRYDIPPEAGGSSRIAVLHSELSDGQRSEIMKQFRKGEIWILVTTDLLARGVDFRGINGVVNYDIPNSAAVYVHRVGRTGRAGREGGIAVTYYTKEDIPYVKSIANVIDVSEKLRGTDEEKSVQKWLLDALPDLSKKKKEELKKHGVKARQTQGTKDDKKTRISTKSGYERRQENKKKALISASRNRKSQPKSGADSGSDDDNQGWQGLED
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase rok1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: BIOB_DESAP
Sequence: MNLQEKTAWITHVARRVIDGDTLSFEEATALLQLPDAVTPFLLGWADVVRKCFHGNRVDLCAIVNARAGRCSEDCRFCTQAACYHTRAPVYPLLPAEGIIRRARAVRSQGIKRFSLVTSGRDPGGDFEKILGITRQLKREVPELKLCASLGIISPTEARALKEAGLDRYHHNLETAASFFPEVCTTHRYEDRVATIRAAQKVGLEVCAGGIIGLGEKPEQRVELALALRELGVTSVPVNILHPVPGTPLATQPPLPALEILRTLAVFRLLLPATTIRYAGGREHNLRDTQVLGLAGGVDALITGDYLTTAGQGTARDRQLIRDLGLEG
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: AHPC_MYCS2
Sequence: MALLTIGDQFPEYDLTAVVGGDLSKVDAKQPDDYFTRVTSKDYEGKWRIIFFWPKDFTFVCPTEIAAFGKLNEDFEDRDAKVLGVSVDNEFVHFQWRAQHEDLKTLPFPMVSDLKRELTAACGVLNADGVADRATFIVDPNNEVQFVSVTAGSVGRNVDEVLRVLDALQSDELCACNWKKGDPTINAGELLAGAV
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.  Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system.  Does not however seem to play a role in detoxification of isoniazid.
What are the official names of this protein?
Alkyl hydroperoxide reductase C, Peroxiredoxin, Thioredoxin peroxidase.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_RHOCS
Sequence: MSMAPIVLAAGGTGGHLFPAEALARELLERGHRVVLVTDVRGTAFGDALREVPVHRIRSATLGGGLLGKARTALELGIGTLQARRLLSRLEPAIVVGFGGYPSFPAVYAAAGLRIPVAIHEQNAVMGRANRMLARRARLICTSFPEVQGMDNVDRARAVRTGNPVRPAVLALRDRPYEAPLPGGSLDILVTGGSQGATVFGEIVPRAVAMLPEDLRLRLGIVQQARAENLQAARDGYAALGVQATLAPFFRDLPERLARCHLMIGRAGASTVAELTVAGRPSILVPYPHATDDHQTANARAVAAAGGAWIMPQPEFTAEALAARLTALLTDPAPLAPAAAAAAAWGLPDAARRLADAVLGAAGLGNGRSTPDSQMRAAE
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ISPE_AERS4
Sequence: MATIRWPAPAKLNLFLNVNGRRPDGYHELQTLFIFLDHGDWLEFEPLPDTDQLTLSPAIPGVPDEQNLIIRAARLLQARLPSPQGAHIRLEKLLPMGGGIGGGSSDAATTLVALNHLWQAGLGEDELAELGVQLGADVPVFVRGRAAFAEGVGERLQPVELPGAWYLVLKPDCHVATAAVFQDPDLPRATPKMAFHNLLEGEWKNDCELLVKKRYPEVANALGWLLEYAPSRMTGTGACVFAQFEDEKAAREVLAKVPKRWDGFVAKGENISPLFVTLQQISDWDIAKR
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: FABH_STRS2
Sequence: MRNHAKISQVAHYLPKKIVTNDDLAQRMETSDEWIRSRTGIGQRHIVTGETTSDLASQVARKLLEKSQLDASEIDFIIVATITPDASMPSTAAMVQAAIGAKNAFAYDLVAACSGFVFALSTAEKLLASGVYKRGLVIGAETLSRSVDWSDRSTAVLFGDGAGGVLLEACEQPTFLAEILRTDGGRGASLTAGIDQKETPFSTQSCQQPFIQMEGRAIFEFATRDVTATMAELLEQADMTVDCVDYFLLHQANIRILDKMARKLGVAREKFPANMDKYGNTSAASLPILLSECVESGMLRLDGSQTILMAGFGGGLTWGTLLLQL
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK20_PIPCE
Sequence: MTRVRRGYIARRRRTKIRLFASTFRGAHSRLTRTITQQKMRALVSAHRDRGRKKRDFRRLWITRINAVIRGSGVSYSYSRLIHDLYKRQLLLNRKILAQIAISNRNCFYMISNQIIKSGECEEFNGII
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: 3DHQ_EMENI
Sequence: MEKSILLINGPNLNLLGTREPHIYGSTTLSDVEESSKGHAASLGASLQTFQSNHEGAIVDRIHAARGNTDAIIINPGAYTHTSVAIRDALLGVEIPFIELHVSNVHAREPFRHHSYFSDKASGIIVGLGVYGYKVAVEHVALNFKPLEKKAAL
What is the function of this protein?
Is involved in the catabolism of quinate.  Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.
What are the official names of this protein?
Catabolic 3-dehydroquinase, cDHQase, 3-dehydroquinate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: FIXF_SINFN
Sequence: MDTMANSILGQEITFLKLDTRVIKNFDKVLTNNIEVVETSLWSVVRKNALKKGAAKALQACASSVLHKRSDYEFLTTGNVLRKKIRLPRLFGNKVISAAYSWIKRVQAALLLDYLKEHLSQYDWDQLIVVVFNGSNYPESVLAEASKGFKRVFVEDGFFPGTLQIDPVGINAANSVPRCSAFYKSGRDFSEGGLPTAVTNRSSKRKFTPVDLAPGFVFVPFQVPSDMQVTLHSPWVKDMYNFYDIVVNAAEQNPEEMFVIKEHPRFKRSVIGSRPPHPRVKFANGNITSELISNARTVVTINSTVGIEALLLGKQVITLGDSCYNIQDLVLRGNDMGRLNAALALRGWLPDDELRRQFLGFLWNYYLVKGSFTEPPTALASRILDCFELDSEVRGAIANLNN
What are the official names of this protein?
Protein FixF.
Protein: LEUD_HAEIG
Sequence: MAGFKQLSGLVVPLDAANVDTDAIIPKQFLQAITRVGFGKHLFHEWRYLDVDGTKPNPEFVLNYPQYQGATILLARKNLGCGSSREHAPWALADYGFKVMIAPSFADIFYNNSLNNHMLPIRLSEEEVEEIFQWVWANESKQIHVDLEAMTVTVGDKVYTFELDEFRRHCLLNGLDNIGLTLQHEDKISAYEKNIPAFLR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: TRUA_RALPJ
Sequence: MTRIALGIQYDGAAFSGWQSQPHGNTVQDALESALRQFAGVALPTTVAGRTDAGVHALGQVVHLDTDLVREPFSWVRGTNAFLPPTVAVRWAQEMPEDFHARFSAHRRTYYYALTFGPTRAPLLEDKAGYVMLPPGQSLDVAAMNEAAQVLVGEHDFSSFRAAECQAKSPVKTMYSIEVRGEGEWVFVRIRGSAFLHHMVRNIMGCLVAIGRGRQPVSWMGDVLAARSRVAAAPTFMPDGLYLAEVGYPDAFSLPASPASSSLFRGVFDEHAGL
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: EFTU_CORGB
Sequence: MAKAKFERTKPHVNIGTIGHVDHGKTTTTAAITKVLADAYPELNEAFAFDSIDKAPEEKERGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKCDMVEDEEIIELVEMEVRELLAEQDYDEEAPIVHISALKALEGDEKWGKQILELMQACDDNIPDPVRETDKPFLMPIEDIFTITGRGTVVTGRVERGTLNVNDDVDIIGIKEKSTSTTVTGIEMFRKLLDSAEAGDNCGLLLRGIKREDVERGQVIVKPGAYTPHTEFEGSVYVLSKDEGGRHTPFFDNYRPQFYFRTTDVTGVVKLPEGTEMVMPGDNVDMSVTLIQPVAMDEGLRFAIREGSRTVGAGRVTKIIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPR_KLEP7
Sequence: MTQQSPYSAAVAEQRHQEWLRFVALLQQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKNELGAGIATITRGSNSLKSAPVELRQWLEQTLLASDK
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_FRATM
Sequence: MSKLIYGLAGPTASGKTSLSILLAKKINAEIISVDSSLVYKGMDIGTAKPTLQEQDGIKHHLIDIIEPTGNFSVADFISSVNKLKKEIWARGREVLLVGGTMLYFKGLIEGLSALPESQAEIREALEYQKKAKGLQYLHQQLNEIDPQSAQKINPNDQQRIFRALEVIMISGKKYSELVKTSKVGGLDEDLKLCALVPNDRSILHKNIESRFRQMLDQGFLDEVQNLHKNPMLTKETTAIRSVGYRQAWEYLDGDISYDEFVKKGIVATRQLAKRQLTWIRNWQSSINIVAMENETKELDILKYFGYK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: IF3_STAES
Sequence: MSTIAKDQTQINEKIRAKELRLIGQDGEQIGVKSKREALEMAERVDLDLVVVAPNAKPPVARIMDYGKYKFEQQKKEKEMKKKQKVINVKELRLSPTIEEHDFQTKLKNGRKFLSKGDKCKVSIRFRGRAITHKEIGQRVLEKFADECKDIATVEQKPKMEGRQMFIMLAPINEK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPP_ANAMM
Sequence: MLKIEGLVLASSSKYRLALLEQIGVVPGEVVSPNIDESLLKGELPRRYCMRMARTKADAEAALRSDKFVLGADTVAYCGKRVLSKTESEDCAVRYLEMLSGRRHRVCTSVCLRSPGGIVHERSVVSVVKFKSMSKGEIEYYISSGQWRGKAGGYGIQGFAGALISWIQGSYSSIAGLPLHETYCLLGGYFDLKHIP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHA_ACIC1
Sequence: MPRWLSAPEHARHRTVAASAGAPWTPRRVAMIAVHTSPLEIPGCGDAGGLNVYVAQIARRLASRGIDVDVFTRATRRDLPPQQRLAPGVTVRNVVAGPLEPLPKDELPVHLCAFTAAVLRAEAMREPGWYDVIHSHYWLSGEVGRVASQRWGVPLVHTMHTLAKVKNAALAEGDVPEPGRRVIGEADVVAAADRLVTNTWTEARQLVDLYGAEPDRIRVVPPGVETAIFRPGDSARARRRLGLPIDGCVVLFVGRLQPLKGPDIAVRAAAEFLSTHPGMRSTFRLVIVGGPSGSRSTEPERLRALAADLGVADAVIFAPPMPPDRLVEFYRAATVTIVPSHSESFGLVALESQACGTPVVAARVGGLTTAVRDGESGLLVDGHDPARYAGAIGRLLDPGLRAELVRGAVAHAMRFHWDNTVEGILGVYRDALAERRTAATQRLASRVG
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: TWHH_DANRE
Sequence: MDVRLHLKQFALLCFISLLLTPCGLACGPGRGYGKRRHPKKLTPLAYKQFIPNVAEKTLGASGKYEGKITRNSERFKELIPNYNPDIIFKDEENTNADRLMTKRCKDKLNSLAISVMNHWPGVKLRVTEGWDEDGHHLEESLHYEGRAVDITTSDRDKSKYGMLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSGTVTLGDGTRKPIKDLKVGDRVLAADEKGNVLISDFIMFIDHDPTTRRQFIVIETSEPFTKLTLTAAHLVFVGNSSAASGITATFASNVKPGDTVLVWEDTCESLKSVTVKRIYTEEHEGSFAPVTAHGTIIVDQVLASCYAVIENHKWAHWAFAPVRLCHKLMTWLFPARESNVNFQEDGIHWYSNMLFHIGSWLLDRDSFHPLGILHLS
What is the function of this protein?
The dually lipidated tiggy-winkle hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development (By similarity).  Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes (PubMed:7583153).  Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity).
What are the official names of this protein?
Tiggy-winkle hedgehog protein, TWHH, Sonic hedgehog protein B, SHHB.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
[Tiggy-winkle hedgehog protein N-product]: Cell membrane; Lipid-anchor. Note=The dual-lipidated tiggy-winkle hedgehog protein N-product (TWHHN) is firmly tethered to the cell membrane where it forms multimers (By similarity). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides. SUBCELLULAR LOCATION: [Tiggy-winkle hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Co-localizes with HHAT in the ER and Golgi membrane.
Protein: LGT_NEIG2
Sequence: MIIHHQFDPVLISIGPLAVRWYALSYILGFILFTFLGRRRIAQGLSVFTKESLDDFLTWGILGVILGGRLGYVLFYKFSDYLAHPLDIFKVWEGGMSFHGGFLGVVIAIWLFSRKHGIGFLKLMDTVAPLVPLGLASGRIGNFINGELWGRITDINAFWAMGFPQAHYEDAEAAAHNPLWAEWLQQYGMLPRHPSQLYQFALEGICLFAVVWLFSKKPRPTGQTAALFLGGYGVFRFIAEFARQPDDYLGLLTLGLSMGQWLSVPMIVLGIVGFVRFGMKKQH
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: P320_TRYBB
Sequence: SEYRQKRTVGEEVTTDMRHVDESHFLTTTHEAYKPIDPSEYRQKRTVGEEVTTDMRHVDESHFLTTTHEAYKPIDPSEYRQKRTVGEEVTTDMRHVDESHFLTTTHEAYKPIDPSEYRQKRTVGEEVTTDMRHVDESHFLTTTHEAYKPIDPSEYRQKRTVGEEVTTNMRHVDESHFLTTTHEAYKPIDPSEYRQKRTVGEEVTTDMRHVDESHFLTTTHEAYKPIDPSEYRQKRTVGEEVTTDMRHVDESHFLTTTHEAYKPIDPSEYRQKRTVGEEVTTDMRHVDESH
What are the official names of this protein?
Microtubule-associated protein P320.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: YBEY_CAMJR
Sequence: MILSDEKCDFLESIASFLSPKDVELVFVDSKEMQEINLEQRKQDKTTDVLSFPLENIDESLPLGSVVINVDLAKEKAKELGHSYEEEISLLFIHAMLHLLGFDHENDNGEMREKEKELIEHFNLPKSLIVRTLED
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_HELPS
Sequence: MKEFDLESYDYDLPKELIANYPILPKEKAKLLVYERRSQKITHTTFEHVLDFFPKNALVVLNDTKVIKARIFGSKHAFLPSKTTEVFFHRFFKDNTALTQIKGKIKVGDKIFFDAHYHAEVLELLHNGQRLIAFYGNKTPLNQANILKLLEQYGHMPLPPYIKRADESLDAHEYQSVFAKHMGAVAAPTASLHFSQNTLEKLLKDFKHAFLTLHVGAGTFLGVETKDIREHQIHTEVLRIPKKSQEILQKSQEILCIGTTALRSVEYFKRLENPNQEAFECDIFLHLANPILHVNYLLTNFHLPKSSLLMLVSAMVGLEKTKEIYQIAIEKKYRFYSYGDGMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMAA1_CAEEL
Sequence: MVVRSLLRVSRLTSASCRHASLAVSSTPKPYIPSVTGVQKSMPFDNLLEQYSRVHWDDSVTYDDPNVQKLFKSLMSGSRAALASAITLVESRHPTKRAQGNMLLKMVLDEEREKYKKFGRDSMIFRVGISGSPGVGKSSFIEALGAELTENRGKKVAVLTIDPTSAMTGGSVLGDLTRMQELSRNPKAYIRQSPTSGSLGGVTRGIHEAVILCEGAGYDIVIIETVGVGQSETSVSDMCDMMCLLLSPAHGDELQGVKRGIMEMSDLLVVTKDDGDLKAKAKMTQAEYISALKFMRPRLDVWRPKVMRSSIMDKESVSEVCSSLYEFWDTIGESGDLERRRQDQMKKWMWNHVKDEIMSVFQKHPKIAHLAPKLENEIRSGKITPGLAAETMIRTFFGV
What is the function of this protein?
May have GTPase activity.  May also bind and hydrolyze ATP.  May function as chaperone (By similarity).  Likely to have a role in propionyl-CoA and adenosylcobalamin metabolism.
What are the official names of this protein?
Methylmalonic aciduria type A homolog, mitochondrial, Methylmalonic aciduria type A protein 1.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GTAT_DICDI
Sequence: MGKRKPIPSINIGNNLNKKLKFSKQDSDQQQQQQQEQQPQQPQQPIIKYKSKREKEIHEKIDKIKSERKFIYKNAERHVKLSLEYAGLALSLPAVLKDLHRALEKFDALESSLIAELESLKIPVKNASTIPVLHPPINHVNTSIATTAAASINNNNNNDNTITTTTTTTTISNDNLASTTNSLPVNSVPRTTATLSDVNSLITATLGPTTAPTIGSSATTGDTTAIDGTNTNVTTDTTTIETTMKKKGRPPLFKEIPENCYVCGVTETPYWRRGTDEGVMVDLCNACGLRYMKLEKKERLLKQKNSTSNVLN
What are the official names of this protein?
GATA zinc finger domain-containing protein 20.
Protein: PIK1A_CANAL
Sequence: MPVAPHELRDTIKSRDLGLFQCIDLLKQHNDNIGVHHQLVQKLYSYSYDELEFFIPQFIQLLVNFETDSMALEDFLLHYCNQFPHFSLIVFWYLQAFLFELRNEPKSYSFQTVRKFINKLQNILFNVETSFHIRGPEFRENMQPALILCGSVASAFSSPLVNEYALPIVRSQGKQQKSFVFKLASFQKSLTRNLTMKNQRLSADAITPVISDDDSKVSNRIQESQRLKTKYSKKKISAALQLDDSENYTTDEEELGYVQTLSRPKIREMKYTEVEENLKINTIIRSKKNRSKTTVNSISFFSDTDQSASMEEYNRSAQSLPELVRTRSRLDLYSSESEAALGTSRNSAELIISKKKFMGSEVKTRPYKELLKILQVNYSKKETSFIMSLQNISLRLSSVPKVARLSALRAELSIINESILPSEIDIPQLLPVTSNKNKKFHKILKLNINEACVLNSAERVPYLLLIEYLSDEIDFNPFSDQNQKIINDCVRKPEVKPNDQISGDDDTSVVSSIQEEMFLDNNASENYNEDGDLGEISLLHSRSSSRDWAKSTPGSPVARSSQEDEKFYGNVSSTTGGTIESSVLADQMRIASLMLQQLESSGQSNTQQFVSIRNRIIESMISLQDQFDFIDYETLKELKTDEQDAGKRKLENDFKLAEDWNEKKHRIRKSSIYGHLENWDLCSVIVKNGDDLPQEAFACQLISLISNIWKKHKVDFWTKRMKILITSANAGLVETITNAMSIHSIKKSLTELSIENGENAKGRIFTLKDYFQKLYGSVDSSKYVKAQENFAISLASYSIICYVLQIKDRHNGNIMLDHEGHIIHIDFGFLLSNSPGSVGFEAAPFKLTSEYVEVLGGLESKAYLKFVDTCKNCFKALRKEWGQIVSIVELMQKGSSLPCFNNGDNTSVLLQQRLQLHLSDEEIDSFIEVYLIEKSVGSMYTRLYDQFQMITQGIYS
What is the function of this protein?
Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.
What are the official names of this protein?
Phosphatidylinositol 4-kinase PIK1a, PI4-kinase, PtdIns-4-kinase.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
What are the subcellular locations of this protein?
Nucleus.