PharMolix/UniProtQA huggingface dataset:
Protein: GPMI_KORVE
Sequence: MPTPKPLVLIILDGWGYAPPSNANAISLARKPNYDKLLTDFPNTLIHTSGRYVGLPPGQMGNSEVGHLNIGAGRVVYMDITKIDLAIENKSLFKNQTLLDAMKHAANGRQLHFFGLLSDGGVHSHQNHLYALLRMAKENGVERVFVHPFMDGRDTLPTNGVKYVDQLQQKMREYGIGKIASISGRYYAMDRDKKWDREKLASDAMLHGRGEGGRYKDPVQGIKESYNKGVTDEFIIPFVCVDDNDQPIGVIRDGDACINFNFRADRARQITRVLARNSGITKDGGRELDAADTLDATIPRDTIPKDLHYTCMTQYDPKFTLPIVIPPDTLTHILANEMAAMNMRNLRVAETEKYAHVTYFFNGGIEKPYPGEERELVQSPKVATYDLKPEMSANGIADVIEHAVEKGAFDVIVVNFANADMVGHSGKIPPTITAVETVDSCLGRVYNVVRKKGGAMLITADHGNAEQMIDPETGGPQTAHTTNPVPFIFVAEDAKKRFSLRPDGALQDISPTMMGILGIPQPKEMTGHDLRVDLTVKK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: UREG_STAAB
Sequence: MANPIKIGIGGPVGAGKTQLIEKVVKRLSKEMSIGVITNDIYTKEDEKILVNSGVLPESRIIGVETGGCPHTAIREDASMNFAAIDELLERHDDIELIFIESGGDNLAATFSPELVDFSIYIIDVAQGEKIPRKGGQGMIKSDFFVINKTDLAPYVGASLEQMAEDTKVFRDKRPFTFTNLKTDEGLDEVIDWIKRDTLLKGLS
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_LEGPL
Sequence: MLESDRLISSQSIVSEDAMDRAIRPLSLSEYVGQDSVSSQMQIFINAARKRNDPLDHVLIFGPPGLGKTTLANIIAHEMGVNIRQTSGPVIERAGDIAAILTNLQQNDVLFIDEIHRLSPVIEEILYPAMEDYKLDIMIGEGPAARSIKLELPPFTLIGATTRAGLLTSPLRDRFGIVQRLEYYSVDSLTQIVARSAHLLGVPTKPEGAREVALRSRGTPRIANRLLRRVRDYSEVKGNGIITVDMAQQALEMLEVDQHGFDLMDRKLLLAVIEHFNGGPVGIDSIAAAIGEEKGTIEDVLEPFLIQQGFLMRTPRGRIATSKAYQHFGFSAIEQE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RPIA1_YERPE
Sequence: MTQDELKKAVGWAALDYVKPGTIVGVGTGSTAAHFIDALGSIKHQIEGAVSSSDASTAKLKSYGIPVFDCNDVDVLDIYVDGADEINGQMQMIKGGGAALTREKIIAAIARKFICIADESKQVGVLGKFPLPVEVIPMARSYVARELIKLGGLPEYRQNVLTDNGNVILDVHNLSILDAIALENQINGIAGVVTVGLFANRGADVALIGTANGVKVIG
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A 1, Phosphoriboisomerase A 1, PRI 1.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: COAX_MYCSS
Sequence: MLLAIDVRNTHTTVGLISGSGDHAKVVQQWRIRTESEATADELALTIDGLIGEDSERLTGAVGLSTVPSVLHEVRLMLEQYWPSVPHVMIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYHRFGTAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELTRPRSVIGKNTVECMQSGALFGFAGLVDGLVNRIREDVAGFSGTDVAVVATGHTAPLVLPDVHTVAHYDRHLTLDGLRLVFERNRDGQRGRR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_DEHMB
Sequence: MDKQEKSLIINEFKKSESDTGSTEVQVALLTARIHQLTTHMIANKHDFHTKRSLLTLVGRRRRLLSYMRNSNGAGYQELIANLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: HGGL1_MAIZE
Sequence: MAPLLAAAMNHAAAHPGLRSHLVGPNNESFSRHHLPSSSPQSSKRRCNLSFTTRSARVGSQNGVQMLSPSEIPQRDWFPSDFTFGAATSAYQIEGAWNEDGKGESNWDHFCHNHPERILDGSNSDIGANSYHMYKTDVRLLKEMGMDAYRFSISWPRILPKGTKEGGINPDGIKYYRNLINLLLENGIEPYVTIFHWDVPQALEEKYGGFLDKSHKSIVEDYTYFAKVCFDNFGDKVKNWLTFNEPQTFTSFSYGTGVFAPGRCSPGLDCAYPTGNSLVEPYTAGHNILLAHAEAVDLYNKHYKRDDTRIGLAFDVMGRVPYGTSFLDKQAEERSWDINLGWFLEPVVRGDYPFSMRSLARERLPFFKDEQKEKLAGSYNMLGLNYYTSRFSKNIDISPNYSPVLNTDDAYASQEVNGPDGKPIGPPMGNPWIYMYPEGLKDLLMIMKNKYGNPPIYITENGIGDVDTKETPLPMEAALNDYKRLDYIQRHIATLKESIDLGSNVQGYFAWSLLDNFEWFAGFTERYGIVYVDRNNNCTRYMKESAKWLKEFNTAKKPSKKILTPA
What is the function of this protein?
Is implicated in many functions such as ABA metabolism, hydrolysis of conjugated gibberellins, conversion of storage forms of cytokinins to active forms.  Also acts in defense of young plant parts against pests via the production of hydroxamic acids from hydroxamic acid glucosides.  Enzymatic activity is highly correlated with plant growth.  The preferred substrate is DIMBOA-beta-D-glucoside.  Hydrolyzes the chromogenic substrate 6-bromo-2-naphthyl-beta-D-glucoside (6BNGlc) and various artificial aryl beta-glucosides.  No activity with cellobiose, arbutin, gentiobiose, linamarin or dhurrin as substrates.
What are the official names of this protein?
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic, Beta-D-glucoside glucohydrolase, Beta-glucosidase 1, ZmGlu1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ATPA_GEOSW
Sequence: MSIRAEEISALIKQQIENYESEIQVSDVGTVIQIGDGIARAHGLDNVMSGELVEFSNGVMGMALNLEENNVGIVILGPYTGIKEGDEVRRTGRIMEVPVGEALIGRVVNPLGQPVDGLGPIETTETRPIESPAPGVMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTSIAIDTIINQKDQNMICIYVAIGQKESTVRTVVETLRKHGALDYTIVVTASASQPAPLLFLAPYAGVTMGEYFMYKGQHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDIFYLHSRLLERAAKLSDAKGGGSLTALPFVETQAGDISAYIPTNVISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGAAQIKAMKKVSGTLRLDLAAYRELEAFAQFGSDLDKATQAKLARGARTVEVLKQDLHAPIPVEKQVAIIYALTHGFLDDIPVEDIRRFEKEFFLWLDQNGQHLLEHIRTTKELPNEEDFNKAIEAFKKTFVVSQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MQO_ECOLI
Sequence: MKKVTAMLFSMAVGLNAVSMAAKAKASEEQETDVLLIGGGIMSATLGTYLRELEPEWSMTMVERLEGVAQESSNGWNNAGTGHSALMELNYTPQNADGSISIEKAVAINEAFQISRQFWAHQVERGVLRTPRSFINTVPHMSFVWGEDNVNFLRARYAALQQSSLFRGMRYSEDHAQIKEWAPLVMEGRDPQQKVAATRTEIGTDVNYGEITRQLIASLQKKSNFSLQLSSEVRALKRNDDNTWTVTVADLKNGTAQNIRAKFVFIGAGGAALKLLQESGIPEAKDYAGFPVGGQFLVSENPDVVNHHLAKVYGKASVGAPPMSVPHIDTRVLDGKRVVLFGPFATFSTKFLKNGSLWDLMSSTTTSNVMPMMHVGLDNFDLVKYLVSQVMLSEEDRFEALKEYYPQAKKEDWRLWQAGQRVQIIKRDAEKGGVLRLGTEVVSDQQGTIAALLGASPGASTAAPIMLNLLEKVFGDRVSSPQWQATLKAIVPSYGRKLNGDVAATERELQYTSEVLGLNYDKPQAADSTPKPQLKPQPVQKEVADIAL
What are the official names of this protein?
Malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: Y2566_VIBVY
Sequence: MKIWVDADACPKVIRETIVRAAERTSVECTFVANHVVPVPRRPNIHSLQVPAGFDIADNEIVKRVEPNDLVITSDIPLADEVITKGGLALSSRGELYTKDTIKARLNIRDFMETMRSSGIQTGGPAALSQTERREFANHLDRILAKR
What are the official names of this protein?
UPF0178 protein VV2566.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: GBLP_MEDSA
Sequence: MAEGLVLRGTMRAHTDVVTAIATPIDNSDMIVTASRDKSIILWHLTKEDKTYGVPRRRLTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLNAGTSARRFVGHTKDVLSVAFSIDNRQIVSASRDRTIKLWNTLGECKYTIQDGDAHSDWVSCVRFSPSTPQPTIVSASWDRTVKVWNLTNCKLRNTLAGHSGYVNTVAVSPDGSLCASGGKDGVILLWDLAEGKRLYSLDAGSIIHALCFSPNRYWLCAATESSIKIWDLESKSIVEDLKVDLKTEADAAIGGDTTTKKKVIYCTSLNWSADGSTLFSGYTDGVVRVWGIGRY
What is the function of this protein?
Plays a role in hormone-mediated cell division.
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta-like protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
Protein: IF2_HAES1
Sequence: MTDEIKKENAPKKLSIQRRTKTTVSGTSTTGKSKEVQVEVRKKRTVTTDLERKAQEQAKLKAKEEAEKRAAEEKLAEKAKREAEKAKAEQIKVEKAKAEQAKASKKNVDVEKEKRRAEEAELRRKADEVARQKAEEKAQKAAEEAKRYADFDDSDNDNGKLDDYSDYHLTSSYALEAENEEERRNENRGRSKNKVVKAKKGGRDDENGNKNERQSDRRNQKDVKGKGKHAKKASALQQAFTKPAQVAKADVVIGETITVAELAAKMAVKATEIIKTMMKMGEMVTINQVIDQDTAQLVAEEMGHKVILRKENELEEMVMEDRDVNAEKVHRAPVVTIMGHVDHGKTSLLDYIRKAKVAAGEAGGITQHIGAYHVETNDGKMITFLDTPGHAAFTSMRARGAKATDIVVLVVAADDGVMPQTIEAIQHAKAANAPLVVAVNKIDKPEANPDRVEQELLQHEVISEKFGGDVQFVPVSAKKGLGIDDLLEAILLQSEVLELTAVKDGMASGVVIESYLDKGRGPVATILVQSGTLNRGDIVLCGFEYGRVRAMRDENGKDIQSAGPSIPVEVLGLSGVPAAGDEATVVRDEKKAREVALYRQGKFREVKLARQQKAKLENMFSNMAEGDVAELNVIVKADVQGSVEAIVQALHELSTAEVKVKVVGSGVGGITETDATLAAASNAIMVGFNVRADATARRVIENENIDLRYYSIIYELLNEIKAAMSGMLQPEFKQEIIGLAEVRDVFRHPKFGAIAGCMVTEGLVKRNNPIRVLRDNVVIFEGELESLRRFKDDVSEVRSGMECGIGVKNYNDVKVGDQIEVFEVVEVKRAI
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_FRASN
Sequence: MARLFGTDGVRGVANADLTAELALALASAAVEEVADRGTPPPGPVDGVPVARSAHGIDHRPLVVVGRDTRPSGEFLEAAVVAGLARAGADVTRIGVVPTPAVSYVVAATGADLGVMLSASHNPMPDNGIKLFAAGGLKLPDDVEDAIERRMAGPAARRPVAAAVGRVRDDSMLVDGYVDHLLATLPGGPGGLRGLRVVVDCAQGAASDLAPRVLRAAGADVIALHADGDGLRINDRSGATHLDSLRDAVVAHGADAGIAHDGDADRCLAVDSAGEIVDGDQILALCALALAERGELERGTVVVTVMSNLGFHHAMRDAGIDVVTTPVGDRYVLEAMRSGAYSLGGEQSGHVVFLRHAGTGDGLLTALQILGRMAETSQPLHELAKAMTRLPQVLVNVRGVDRARAETSDELRAAVADAEAELAGAGRVLLRPSGTEPLVRVMVEAPTDELARDVAGRLADVVQRALR
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: IL27A_PIG
Sequence: MGQMADDLGWRLSLLLLSLLLARAGVWGFPRPPGRPPLSLQELQREFKVSLHLARKLLSEVRVQARHFAESHLPGVNLDLLPLGEQLPNVSLNFQAWRGLSDPERLCFLSMTLRPFHTLLGGLGSQGFWTSSERMQLWAIRLDLRDLQQHLRFQVLAAGFNLPGQEEEENEAGRELLPGAPGGPSKPAAQVSWPRLLYTYQLLHSLELVLSRAMRDFLLLSRAGNPAPALGFPTPSSPP
What is the function of this protein?
Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity.  Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells.  Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17).  It drives rapid clonal expansion of naive but not memory CD4 T-cells.  It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction.  IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation.  It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways.  It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment.  It suppresses the expression of GATA3, the inhibitor TH1 cells development.  In CD8 T-cells, it activates STATs as well as GZMB.  IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production.  Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells.  While IL-27 suppressed the development of pro-inflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1.  IL-27 has also an effect on cytokine production, it suppresses pro-inflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3.  Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells.  Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9.  In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II (By similarity).
What are the official names of this protein?
Interleukin-27 subunit alpha, IL-27 subunit alpha, IL-27-A, IL27-A, p28.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted. Note=Does not seem to be secreted without coexpression of EBI3.
Protein: FABZ_SYNFM
Sequence: MDIAKIMGYLPHRYPFLLVDRILELTSEEIVGLKNVTINEPFFQGHFPGEPIMPGVLIIEALAQTGGVLAFTLVSDFRGKPIYFMGMDKVRFRKPVRPGDQLILKLKILKRRGPTFKMSAEAFVEEQLVAEAELLATIGAAKSEREA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBT_SYNP6
Sequence: MESLVYIFVFVVALGVLFFAIAFREPPRIGK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: CYB_MARBR
Sequence: MTNTRKIHPLIKIINHSFIDLPAPSNISTWWNFGSLLGLCLAIQIFTGLFLAMHYTSDTMTAFSSVAHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYTYSETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSATPYIGTTLVEWIWGGFSVDKATLTRFFAFHFVLPFIIAALVMVHLLFLHETGSNNPSGLISDSDKIPFHPYFTIKDILGAVLLILILMILVLFSPDLLGDPDNYTPANPLNTPFHIKPEWYFLFAYAILRSIPNKLGGVLALIFSILILMLFPLLHLSKQRSMMFRPLSQCVFWILVADLITLTWIGGQSTEYPYNIIGQLASILYFAIILLILPTISLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RUTA_ECO44
Sequence: MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVLFMVIADETDDAARTKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHLPTLTQEVA
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
Protein: PSBJ_PANGI
Sequence: MADTTGRIPLWIIGTVAGILVIGLIGIFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RACG_DICDI
Sequence: MKSIKVCVVGEGGIGKTSMLLSYTSNSISNEYQPTVFDNYSTLLMHNKKPYNLSLWDTAGQEEFSKLRRLSYPQTDVFLLCFSLINPSSFSNILDSWVQELNENCPNTPIVLVGTQMDLKSNSVILDRLCEKKQLPISTQQGIELSKKINAFDFVECSALTQKNLHLVFEKAIDACEAHQKCQSKEKKKNNKKFKKNCIIM
What are the official names of this protein?
Rho-related protein racG.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: RS4_BORRA
Sequence: MNRKSIAKGKLVRRFGVNIFEQPKYDKLLKKKTNPPGMHGRSRRTKVTEYGKQLIEKQKVKFTYGVSERQLTNVFKEARRQHGVTGDNLLALLERRIDNIVYRAGFAISRAHARQIVSHGIIILNGRRVTIPSITLRANDIIQVKEKDSFKKLVRSNIEKTSTLRKLPDWIEVNADALNVKIIRTPSRDEIPTLANEQMIVEYYSKRA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: IFNG_CERAT
Sequence: MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGDPDVADNGTLFLDILRNWKEESDRKIMQSQIVSFYFKLFKSFKDDQRIQKSVETIKEDINVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAVHELIQVMAELSPAAKIGKRKRSQTFRGRRASQ
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL37A_DESA1
Sequence: MGKTKVVGIAGRYGTRYGSTLRKKIRDILEKRYSPHTCPFCGHKGKVYRLSTGVWACKKCGAKWAGGAYMPKTESAKLFSDIIIRE
What are the official names of this protein?
50S ribosomal protein L37Ae, Ribosomal protein L43e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL43 family.
Protein: Y740_AQUAE
Sequence: MNKLSLFVYLFFFLSFLFLFLYLLQPFFNPIVWAIVFGIVLYPLYGFIKRKLKSENLAAFLVIFIVLVAIVIPFTIFAVITAQQIIVFSIKVVNFVQTHSVNDLINSLKEIPFLKEKRESLEPLLNYLQSEEFRRALINALNSILTFVGDRLRSYVYTAGTSLFHVFVFLLTLFFILRDGEKVLKEIINSIPMKREDLEEILKTIYRTVLAVIYGTVGTAVAQSIMGFIGYSLAGVEFALIWALITFFAAFVPPFGAAFVWVPMDIYLFTTKGIKEGLILLFFGTFLISTMDNIVRPLVMKQGIKLPYVALFFSTIGGLIKFGFIGVFLGPIILSTMLASVKIYRRRVIHSGI
What are the official names of this protein?
Putative transport protein aq_740.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.