PharMolix/UniProtQA huggingface dataset:
Protein: KVD15_HUMAN
Sequence: MEAPAQLLFLLLLWLPDTTGEIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASIRATGIPARFSGSGSGTEFTLTISILQSEDFAVYYCQQYNNWP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 3D-15.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: CBPYA_CHAGB
Sequence: MRIAASTVLFGAASAASFQQQAQHVLSGGFGKAQEAMKPISDAFTDAAGRPFESFEDAFSGMTAETKALWEEIKLLVPDSAFKDLSWLSKPKPHHRRDDWNHVVKGADVQGMWVQDANGKSHRQVDGRLEEYNLRVKAVDPSKLNVDSVKQYSGYLDDEANDKHLFYWFFESRNDPKNDPVILWLNGGPGCSSLTGLFLELGPSSIDKTLKVVNNDFSWNNNASVIFLDQPVNVGYSYSGSSVSNTVAAGKDVYALLTLFFHQFPEYAKQDFHIAGESYAGHYIPVFASEILAHKNRNINLKSVLIGNGLTDGLTQYEHYRPMACGEGGYPAVLGEAECRSMDNALPRCQSLINNCYESGSVWSCVPASIYCNNAMIGPYQRTGRNVYDIRGPCEDSSNLCYSGLGYISDYLNQQSVMDALGVEVSSYDSCNFDINRNFLFQGDWMQPFHRLVPKILEEIPVLIYAGDADYICNWLGNRAWTEALEWPGKKDFNAAKVKDLKLSGAEKEYGKVKASGNFTFMQVYQAGHMVPMDQPENSLDFLNRWLNGEWFAK
What is the function of this protein?
Vacuolar carboxypeptidase involved in degradation of small peptides.  Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).
What are the official names of this protein?
Carboxypeptidase Y homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: MASZ_RHOE4
Sequence: MTERVQVGSLQVAKVLYDFVVEEALPGTGVDAETFWAGADKVITELAPKNRDLLAKRDDLQAQIDQWHRDHAGAPIDAAAYKAFLQEIGYLLPTPAEFSVTTANVDTEITSTAGPQLVVPILNARFALNASNARWGSLYDALYGTNAISEENGAEKGSGYNKVRGDKVIAWAREFLDAAAPLASGSHADSTKYVIDGSELKITLADGTVTTLAQPEKFVGYLGAKDAPTSILLLNNGLHAEIQIDASSPIGSTDAAGVKDVVLESAVTTIMDFEDSVAAVDADDKVVGYRNWLGLNRGDLSEEIKKGAKSFTRTLNGDRKYTAVDGSELSLHGRSLLFVRNVGHLMTNPAILDADGNEVPEGILDALITSTCAVHGLSISDANGPLDNSRTGSIYIVKPKQHGPEEVAFTTELFGRVEQVLGLPENTLKVGIMDEERRTTVNLAACIKEAVDRVVFINTGFLDRTGDEIHTSMEAGAMVRKAEMKKQKWIGAYEDWNVDTGLACGLQGKAQIGKGMWAMTELMADMLEQKIGHPKAGANTAWVPSPTGATLHATHYHRVDVFAVQDSLKGKPRASVDDILTIPLAPSTDWTDAEKKEELDNNCQSILGYVVRWIDAGVGCSKVPDIHDVALMEDRATLRISSQLLANWLRHGIVSESDVVSALERMAPVVDRQNEGDAEYRNMAPDFDSNIAFQAAKELILEGAKQPSGYTEPILHRRRREYKAANA
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMP52_CANGA
Sequence: MSKQTAVVLGATGLCGEHLLKSAVASQAFEKVYSISRRSLPYVADCEQIVDKDSSSWASLLPKENFKFLFTSLATTRAAAGGFDKQYQIDHDLNLELAKASKANGCETIVLVSSTGANKNSWMPYLRMKGEIEEDIIALNFKHTIILRPSALLGDRRDHHKGFGNDLFVKIGNCFYRSRLQSIMGYPVQGEEVGIAGVQAALQEAEKNTESPTVRYVGSSEILELVDNFKNNS
What are the official names of this protein?
Protein FMP52, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the FMP52 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein.
Protein: SECB_PSEU2
Sequence: MTDQPNNDAVANEENGPQFSLQRIYVRDLSFEAPKSPAIFRQEWTPTVSLDLNTRQKQLEGDFYEVVLTLSVTVNNGDEVAFIVEVQQAGIFLIKGLDDGAMSHTLGAFCPNILFPYAREAIDNLVVRGSFPALMLAPVNFDALYAQELQRMQEAGETPTVQ
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFK1_SCHPO
Sequence: MDNDYTTSTTTSRRPRFWGFFFILFPLVSFLMWTIGLIVLLGLWSTQDKWHTPSEPDPVYLSDMGAYTKGFFIPMCVITGVFYFLTFIMIRLARQWGWIYPTGRKVETYLGWFAALTGAAAASCLISLSIRDDVHHDNVHWKFTAAFVVLAFVSAASNIFEWLSATRYYPQSSLLRVSFIFKFVIIVVGIICAIAFGGLHHNYRGRSARFEWVVCFLWSIYICLLCLDLAPALFYDSLASAPDLEKGAYATSVPESYVAPMEPPAAVLPDGEERYATPDLVPDTTAQYPYASATEPGVSNIPETRPERPVVYNMDVSQTTTTTRPVLA
What is the function of this protein?
May control the production of phosphatidylinositol 4-phosphate (PI4P).
What are the official names of this protein?
Protein sfk1.
What is the protein family that this protein belongs to?
Belongs to the SFK1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOE_STRS2
Sequence: MELNVFAGQEKSELSMIEVARAILEERGRDNEMYFNDLVNEIQNYLEKSNSEIRAALPTFYSDLNVDGSFIPLGENKWGLRSWYAIDEIDEEVITLEEDDEDAPKRKKKRVNAFMDGDDDAIDYGHDDPEDEDNYPGSVSSEYDDENPDDEKDEVESYDQKSTKLSQMTNWMKRMLI
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: U2A2B_NICPL
Sequence: MPDYEGNGEDIDNYTGGSSPPPKSRSSHGHGPTPDDYSDSKSQHSSRENEKDRDSSRSREKDRERGRDKDRDRDRDRDRGRDRDRGRDRDKDREREKDRDRHHGDRHRDRSDRREKERTRDRDDDDRHRTRDYDQQREHAKDRESRHRHRSRSRGRSEHRSRSRSRSRSKSKRISGFDMAPPTSAMLPGITAAAGQVPGTNPPIPGMFPNMFPLASGQFGALPVMPIQAMTQQATRHARRVYVGGLPAHANEQSVATFFSHVMSAIGGNTAGPGDAVVNVYINYEKKFAFVEMRSVEEASNAMALDGIIFEGAPCKVRRPSDYNPSLAATLGPSQPNPNLNLAAVGLSPGSAGGLEGPDRIFVGGLPYYFTEAQIRELLESFGPLRGFDLVKDRETGNSKGYAFCVYQDVSVTDIACAALNGIKMGDKTLTVRRANQGTTQPKPEQESVLLHAQQQIALQRLMLQPATLATKVLSLTEVISADELNDDEDYQDILEDMRTECGKFGSLVNVVIPRPSPNGEPTPGVGKVFLEYADVDSSSKARQSLNGRKFGGNQVVAVFYPENKFYEGDYDG
What is the function of this protein?
Necessary for the splicing of pre-mRNA.  Binds to the U -enriched regions of plant introns.
What are the official names of this protein?
Splicing factor U2af large subunit B, NpU2AF65b, U2 auxiliary factor 65 kDa subunit B, U2 small nuclear ribonucleoprotein auxiliary factor large subunit B, U2 snRNP auxiliary factor large subunit B.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RM03_RAT
Sequence: MPGWRLLAQGGAQVLGGGAGGLGAAPGLGSRKNILFVVRNLHSKSSTWWDEHLSEENVSFVKQLVSDENKAQLTSLLNPLKDEPWPLHPWEPGSSRVGLIALKLGMMPLWTKDGQKHAVTLLQVQDCHVLKYTPKEDHNGKTATLTVGGKTGSRLYKANSILEFYRDLGLPPKQTTKIFHVTDNAVIKQGTPLYAAHFRPGQYVDVTAKTIGKGFQGVMKRWGFKGQPASHGQTKTHRRPGAISTGDIARVWPGTKMPGKMGNQNRTVYGLKVWRVNTKHNIIYVNGSVGHRNCLVKIKDSTLPAYKDLGKSLPFPTYFPDGDEEELPEDLYDESVRQPSDPSITFA
What are the official names of this protein?
39S ribosomal protein L3, mitochondrial, L3mt, MRP-L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MLTF_SHESM
Sequence: MTRFLFAIILGFLLTACQQVTVEETEYVPHKLTELRVGTLYGPQIYMTSGQGNSGFDYDMAVLFAEYLDVPLKMVPYTNRAELYEALKKNEIDIIAAGMTETPARREQFRLGPPLYRVNQVLVYREGMPTPKDITDLKGKITVIADSSFVETLTQLQKRHPTLVWDQVTDKDSEELLAMIANKEIDYTIADSSSVQINRRYLPDLRSGLVLEEKLDVVWLLPPTHSDGLMSQLLAFWHQEKLAGTLDHLNEKYFGHVKRFDYIDTRAFLRAIETVLPRYRQLFETHAGDLDWRKLAATSYQESHWNPNARSPTGVRGMMMLTQPTAKEIGITNRLDAEESIRGGAAYLRDMINRLPESIPESQRMWFALASYNIGYAHVEDARKLAESMELNPNAWRDLKKVLPLLQKRKYYQKTRYGYARGSEAVHYVDSIRRYYDTLVWVDNQSKQQNSDEEEPSDLASEDGPAPVPGTLSPDKPK
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: RBSD_COPPD
Sequence: MKKTILINSRLSEVIASMGHTDTIAIADSGLPIPKGVERIDLALTRDIPRFLDTLRVILSELCVEEAIIATEMKEKSPETYAELLKILGNIPIKEVSHEELKVMTKECVAVVRTGEYTPYCNIILRSGVVF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRBP2_XENLA
Sequence: METLTELGDELTLGDIDEMLQFVSNQVGEFPDLFEEQLCQSYQGNNAMDTTLPKAYNQAAQQPYTTSAPQPQLLPVKAPPQATPQRTAPLLQPRPVVQTSPQPQLQQQTVMLTPNFSTAPQTRIIQQPLIYQNAATTSFQVLQPPVQSLMTTQQMQPVTIQQQVQTVQAQRVLTQAANGTIQTLTPATVQTVTPHVQQVPVLVQPQIIKTESLVLTAVKADGSPVMTAVQNPAITTLAGTLQTTALQVPTLMGSNGTILTTMPVMMGQEKMPIKQVPGSLKLAEVPKEGERRTTHNIIEKRYRSSINDKIMELKDLVMGTDAKMHKSGVLKKAIDYIKYLQQVNQKLRQENMALKLANQKNKYLKGIDLSSLVDTSIGMKIDEFNQNALMMSPPASDSGSPAVFSPYSVDSEPGSPLLDDEKVKDEPDSPTGLGMMDRSRMLLCTMTFLCLSFNPLTSLLHPESGQYSERAVQHGTGRTMLGVEMSGFYGSWFDWLIPTIILWLVNGVIVLSVFMKLLIHGEPVTRLHSRSSVKFWRHRKQADLDLAKGDFGAAALNLQTCLCVLGRSLPATRLDLACSLSWNIIRCSLQKISLVRWLLKHSPGYCKKAEFQDEATTSARDAALVYHKLHQLHLTGKLPSNWNCSGLNLALCAVNLAECAGNKISPTLLAEIHLTTAIQMKTSFPSRFRFLTAYFLGYAQNASSEETLPDPMRWLAHPLGKYFFINSNWALKSAAKDSLYTSTRNPANPVTQIHRAFCESLLEKAMYTMAKPETSKAASEEESCEFSRAQEYLKLLSGFADSVGNVASLPLGGSSPMSSADPICRWWYSVSSMAIGWLQGDDSVVKSHFAEVERIPKLLDSDNPLVKAVIHMCRAMQAAVLGKCDGQQNSFYHCEKASAFLWNSLNISSTGNTNLNKVVQLLICDLLLSLRTSLWQKQSSSPAAGDSIHAPTPALTGFQRDLSSLRRLSLTFKPAHCKLFLHEATVRLMADASPTRTHQLLQHSLQKCTALANKQGDLDSLPGQRERATAILLACRHLPLSFLSSPGQRAIMLAEAARTLEKVGDRRSYHDCQQMMVKLSGGTAMAAS
What is the function of this protein?
Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis.  Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3').  Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').  Regulates transcription of genes related to cholesterol synthesis pathway.
What are the official names of this protein?
Sterol regulatory element-binding protein 2, SREBP-2, Sterol regulatory element-binding transcription factor 2.
What is the protein family that this protein belongs to?
Belongs to the SREBP family.
What are the subcellular locations of this protein?
[Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane; Multi- pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed. SUBCELLULAR LOCATION: [Processed sterol regulatory element-binding protein 2]: Nucleus.
Protein: VMXCA_CROAT
Sequence: TPDHQRYVELFIVVDHGMYTKYNGD
What is the function of this protein?
Metalloprotease that is highly active against alpha-(FGA) and beta-chains (FGB) of fibrinogen molecules.
What are the official names of this protein?
Snake venom metalloproteinase catroxase, SVMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACOX_SYNY3
Sequence: MVTSPPTSSPSQRSYSPQDWLRGYQSQPQEWDYWVEDVEGSIPPDLQGTLYRNGPGLLEIGDRPLKHPFDGDGMVTAFKFPGDGRVHFQSKFVRTQGYVEEQKAGKMIYRGVFGSQPAGGWLKTIFDLRLKNIANTNITYWGDRLLALWEGGQPHRLEPSNLATIGLDDLGGILAEGQPLSAHPRIDPASTFDGGQPCYVTFSIKSSLSSTLTLLELDPQGKLLRQKTETFPGFAFIHDFAITPHYAIFLQNNVTLNGLPYLFGLRGAGECVQFHPDKPAQIILVPRDGGEIKRIPVQAGFVFHHANAFEENGKIILDSICYNSLPQVDTDGDFRSTNFDNLDPGQLWRFTIDPAAATVEKQLMVSRCCEFPVVHPQQVGRPYRYVYMGAAHHSTGNAPLQAILKVDLESGTETLRSFAPHGFAGEPIFVPRPGGVAEDDGWLLCLIYKADLHRSELVILDAQDITAPAIATLKLKHHIPYPLHGSWAQT
What is the function of this protein?
Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively.  Also shows activity toward lycopenals and the corresponding alcohols.  Does not cleave beta-carotene or lycopene.
What are the official names of this protein?
Apocarotenoid-15,15'-oxygenase, ACO, 8'-apo-beta-carotenal 15,15'-oxygenase, Diox1.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
Protein: THYX_MYCLE
Sequence: MAQIAPLRVQLIAKTEFLAPPDVSWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAAYIKHIIDVGHVAVLEHASVSFYISGISRSCTHELIRHRHFSYSQLSQRYVPEKDAQVVVPPDMEDDDELQQILIAAVEASRATYTELLVKLNAKLMAGELGGNRAVLRRKQARQAAHAVLPNANETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIVCLRRLVDVAPAVFADFEITALADGTEVATSPLATEA
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: SECB_RICPR
Sequence: MSTINTDTSEAMPHISVNAQYIKDLSLENPSAPSSLAALDQRPQIDLSLDINITNLSEENFYEVELNIEAIARNEKYKLFQIELKYAGVFNLINIDSEQHPILLSVHCPAMIFPFARKIIASCTQDAGFQPLMIDPIDFGALYHKKMSEHQN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POTA_UREPA
Sequence: MEKTLLHLRDITKIYDDGFAAVNKFDLKIKKGEFVTLLGPSGCGKTTMLKIIAGFEQPTNGKILYNGIDIKDMPIRLRPTSTVFQDYALFPNMTVKQNIKYGLKLMRKPKDNVDQSIYLQADKVYNSASKKANEKIKELKKQRRGLLAEIKKMDLKYQKNKNIFEIKEMRKNQYLGTLDELYQKQGINKNGKPGFLNYFKSWFSHEKLNLNDPIDREIFNLKKAYKEKSGLDKRYDKITYKYNDLDYWESYWATYPQLKKEQFENKNITRLLTKEEVEKEANRVINLVGLSARKDSYPSDLSGGMQQRVALARSLVIQPEIILLDEPLSALDAKVRKQLQDELKKLHKNLGITFILVTHDQEEALSLSDKVVVMSNGQIEQVGKPSDIYDSPNSLWVANFIGKTNIFEGHYIAKGEVEFDGITSKTDVINGFSENEACYIMIRPEDFDVVKKDEGSINARVESVLYKGLMWDIKCKYNDMIISVEGVNKVNEGDEIGLDWDDIDVHVIKKDYLNNEQAI
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: OST4_SCHPO
Sequence: MTDVQLQNIVTTFGISMMLLIILYHYLSRPQA
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 4 kDa subunit, OTase 4 kDa subunit, Oligosaccharyl transferase 4 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the OST4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: ENK11_HUMAN
Sequence: MPGAIDDHCPAQPGEEGTAFNVTMGYKYPPLCLGHATRCIHLETQVWAAYLLERLATGKWGHLVSGLSLCPLRQMKRGVIGDTPYFQYKPVGKLCPKNFEGPSKTLIWGDCVNSHAVVLKNDSYALVIDWAPKGYLKNTCSSGGGEFLEATYFISYWEDEDHHPTLHRWFGSFFTLKWEDKDITLHPQGLV
What is the function of this protein?
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.  Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity).
What are the official names of this protein?
Putative endogenous retrovirus group K member 11-1 Env polyprotein, Envelope polyprotein, HERV-K_1p13.3 provirus ancestral Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-8) env subfamily.
What are the subcellular locations of this protein?
Virion.
Protein: AROK_PYRFU
Sequence: MRGLGKGSSAITVVNAFATGKGGAIGIDLWTEAKVKITDGEVKGKILVNGLEFNDFRVVNAVLDVMRRYSGIEFGIEFEINSEIPVGKGLKSSSAVANALVEAIARALRLNIPGIKVVKLGVEAAKKAGVTLTGAFDDACASYFGGLCLTDNLRVELLKRIEIDELPVVILVPNETVLTEELKGVDFLKIAPYVEEAFKLAIKGEWKKALVLNGLIYSTFLSYPPEPISKALHLGAVVGLSGKGPSVFAITDEPERIEEVWREFGDVIITSTR
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_BURP1
Sequence: MQLLTIGINHHTAPVALRERVAFPLEQIKPALSTFKSVFLGHPAPNAPEAAILSTCNRTELYCATNDRAARDAAIRWMSDYHRIPADELAPHVYALPQSEAVRHAFRVASGLDSMVLGETQILGQMKNAVRTASEAGSLGTYLNQLFQRTFAVAKEVRGTTEIGAQSVSMAAAAVRLAQRIFEQVAQQRVLFIGAGEMIELCATHFAAQGPRELVVANRTAERGAKLAERFGGRAMPLADLPARMHEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVGKLKDVFLYTVDDLGAIVREGNASRQAAVAQAEAIIETRVQNFMQWLDARSIVPVIRHMHTQADALRRAEVERARKMLARGDDPDAVLDALSQALTNKLIHGPTSALNRANGADRDSLIDLMRGFYQHAPRSSDTSDR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: VG21_ICHVA
Sequence: MSATQGPLTEAANGCDDTGLGKTKNHWDGAVPRTTGEPRSLLGENRASSVLTTGLGPKPGPVWVDPRIRFHGVSESLPLTDTPWGPPPSPMDALGHGVMTPSGLKWCPPPPPKTESRSFLELLAMHQKAQADRDDTVTGETETTAREEDDVIFVEETNVNNPDVIEVIELKDVTETGHGTLKRRYPMRVRRAPKRLVLDEQVVDDYPADSDDDTDAESDDAMSVLSDTCRTDDDASSVSSCGSFITDGSGSEESEDSASDETDDSDFDTDELTSESEEEESESESESESESESESE
What are the official names of this protein?
Uncharacterized protein ORF21.
Protein: NRDR_LACGA
Sequence: MECPNCHKNASRVIDSRPSDENRAIRRRRECENCGFRFTTFERVERSPLLVIKNDGTREAFNRDKILHGVMMAAQKRPISSEQLDTLVDHVENEIRKQGLNEISSKDIGNLVMKELANLDDVAYIRFASIYRQFKDVSGFMEAMEDMMAKHDKE
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RECQ5_HUMAN
Sequence: MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYFGDALPACAKGCDHCQNPTAVRRRLEALERSSSWSKTCIGPSQGNGFDPELYEGGRKGYGDFSRYDEGSGGSGDEGRDEAHKREWNLFYQKQMQLRKGKDPKIEEFVPPDENCPLKEASSRRIPRLTVKAREHCLRLLEEALSSNRQSTRTADEADLRAKAVELEHETFRNAKVANLYKASVLKKVADIHRASKDGQPYDMGGSAKSCSAQAEPPEPNEYDIPPASHVYSLKPKRVGAGFPKGSCPFQTATELMETTRIREQAPQPERGGEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGSAHYGGPSPEKKAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLASAPEAEGACPSCEGVQGPPMAPEKYTGEEDGAGGHSPAPPQTEECLRERPSTCPPRDQGTPEVQPTPAKDTWKGKRPRSQQENPESQPQKRPRPSAKPSVVAEVKGSVSASEQGTLNPTAQDPFQLSAPGVSLKEAANVVVKCLTPFYKEGKFASKELFKGFARHLSHLLTQKTSPGRSVKEEAQNLIRHFFHGRARCESEADWHGLCGPQR
What is the function of this protein?
DNA helicase that plays an important role in DNA replication, transcription and repair (PubMed:20643585, PubMed:22973052).  Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability (PubMed:20231364).  Associates also with POLR1A and enforces the stability of ribosomal DNA arrays (PubMed:27502483).  Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress (PubMed:22013166).  Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis (PubMed:28575661).  Required for efficient DNA repair, including repair of inter-strand cross-links (PubMed:23715498).  Stimulates DNA decatenation mediated by TOP2A.  Prevents sister chromatid exchange and homologous recombination.
What are the official names of this protein?
ATP-dependent DNA helicase Q5, DNA helicase, RecQ-like type 5, RecQ5, RecQ protein-like 5.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
[Isoform Beta]: Nucleus, nucleoplasm. Nucleus. Note=Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks. Re- localizes from the nucleolus into the nucleus after replicative stress and significantly associates with WRN during S-phase (PubMed:23180761). SUBCELLULAR LOCATION: [Isoform Alpha]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform Gamma]: Cytoplasm.