PharMolix/UniProtQA huggingface dataset:
Protein: NAGB_PECAS
Sequence: MRLIPLTTAADVGKWAARHIVEKINAFKPSAERPFILGLPTGTSPLEAYKSLVTMHKAGLVSFKHVVTFNMDEYVGLPTDHPESYHTFMHQNFFNHIDILRENINLLNGNAADTTAECRRYEEKIKSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTEETRIANSRFFGGDVSLVPKFALTVGVGTLLDAEEVMILVTGRNKAQALQAAVEGNVNHMWTISCLQLHAKAIMVCDEPSTMELKVKTVKYFRELETESMKNL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: CPCE_SYNE7
Sequence: MSEAGTPAEALTYEQAIANLRQTADTGDRYYAAWWLGRFRMKQPEAIALLIEALDDSLDRAPDGGYPLRRNAARALGKLESPEAIAPLIACLQCEDYYVREAATQSLGELQATVAVPALLKLLEGGPEAIAAIPGKPHLTQPADAVMETLGQLRATVAVPVVQAFLEHPIDKIRLAAARSLYQLTGDDHYAERVVQGLSDPKLQRRRSALMDLGAIGYLPAAPQIAQTLAENSLKLISLKGLLDTHLRQQTPEAIAELDESAIALMDLMDGLL
What is the function of this protein?
Required for the chromophorylation of the cpcA gene product.
What are the official names of this protein?
Phycocyanobilin lyase subunit alpha, Phycocyanin operon protein CpcE.
What is the protein family that this protein belongs to?
Belongs to the CpcE/RpcE/PecE family.
Protein: ECPA_ECOL5
Sequence: MKKKVLAIALVTVFTGTGVAQAADVTAQAVATWSATAKKDTTSKLVVTPLGSLAFQYAEGIKGFNSQKGLFDVAIEGDSTATAFKLTSRLITNTLTQLDTSGSTLNVGVDYNGAAVEKTGDTVMIDTANGVLGGNLSPLANGYNASNRTTAQDGFTFSIISGTTNGTTAVTDYSTLPEGIWSGDVSVQFDATWTS
What is the function of this protein?
Part of the ecpRABCDE operon, which encodes the E. coli common pilus (ECP).  ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition.  Major subunit of the fimbria (By similarity).
What are the official names of this protein?
Common pilus major fimbrillin subunit EcpA, MatB fimbrillin.
What is the protein family that this protein belongs to?
Belongs to the EcpA/MatB fimbrillin family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: VP61_NPVOP
Sequence: MMERQYQSVRSYLINNQHNAIAAGPFLQRVAGPEAHSVGRNVGDRAVRLNRQAVLDLLKLAEDIYADTAYMQADQPEASSRHFATLNRMRLLLIGVQDPDARRNLNSVLARIEALLRVDVVNDAEVNVLSGDFYEEYSKYISYQQTFAQTPTASASQQTQTSLPRPQTSLPRQTQASLPQQTPFDQPEMVSPPSFVHTTPAILPQTTQPPATDTFSRPSDEFVYVPGKERAVPDTRFKPPVPPKPEHLKSRPSSVATNAAGATPVAPPPPPFPSADVTTSMPPPPPPFPSADVTTSMPPPPPMVDLATSMPPPPPPPPPMVDLATSMPPPINNAINNLLIDAMVAETNKNAGDNRSALLDQIKQGKTLKKTQPADGAPATDPRSTLLSEIRQGKTLKKLRKIEDQSSTQTLLKDVDTTDKTKTILKNFVTNIDRISKQEQEEKDRLDTITKRRPAVEHTDGNSTGNNSDDWRDD
What is the function of this protein?
Probably plays an important role in the persistence and survival of the virus.  May be a structural component in the envelope of the polyhedron or the envelope of the polyhedra-derived virus (PDV) (By similarity).
What are the official names of this protein?
61 kDa protein homolog.
Protein: SPRT_ECOSM
Sequence: MKTSRLPIAIQQAVMRRLREKLAQANLKLGRNYPEPKLSYTQRGTSAGTAWLESYEIRLNPVLLLENSEAFIEEVVPHELAHLLVWKHFGRVAPHGKEWKWMMESVLGVPARRTHQFELQSVRRNTFPYRCKCQEHQLTVRRHNRVVRGEAVYRCVHCGEQLIAK
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_SYNAS
Sequence: MKKIAVYPGSFDPITNGHLDIIKRGLSMFDELIVLIAYNAAKSSLFTVQERIEMIQEALHDRKGVRVDSYDGLLVDYVRKEGGNVILRGLRAMSEFEYEFQLALMNRRLNRNIETVFLMTGYKWFYTSSTIIKEASRLGGSPKGLVPEVVFRKMQEKYPLMNKGK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMRA_STRPN
Sequence: MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSQQVAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYWLIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAELFGIRTVFLLVGSFLFLAAILTICFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLFLTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDKVGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPKAGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYHAVFYATSLCVAFSCLFNLIQFRTLLKVKEI
What is the function of this protein?
Efflux pump for various substrates.
What are the official names of this protein?
Multi-drug resistance efflux pump PmrA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YS31_CAEEL
Sequence: MQFSLSYLISIFYIILITSETTAFSPKRPNLYIWLAQNSYICDPTLLNKRTHRFLTPWESVRLRCSCGDPLATKSACGRKHGNSNQKLACFRLPDPCLREYAVIFEHGGNRLSVPLPPSKPHRIVTAVRKTVTTKHSQRTPKIVSTIPVGAVLRVKKVKEKL
What are the official names of this protein?
Uncharacterized protein ZK1321.1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TVA84_HUMAN
Sequence: MLLLLVPVLEVIFTLGGTRAQSVTQLGSHVSVSEGALVLLRCNYSSSVPPYLFWYVQYPNQGLQLLLKYTSAATLVKGINGFEAEFKKSETSFHLTKPSAHMSDAAEYFCAVS
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 8-4, T cell receptor alpha chain V region PY14.
What are the subcellular locations of this protein?
Cell membrane.
Protein: Y2122_DICDI
Sequence: MSTDNFEKIKGRPTQKEEWQLKEWEKEKDENNRLFQEQKQKTTNRKG
What are the official names of this protein?
Putative uncharacterized protein DDB_G0293796.
Protein: IRX4_MOUSE
Sequence: MSYPQFGYPYSSAPQFLMTTNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATARHELNSAAALGVYGSPYGSSQGYGNYVTYGSEASAFYSLNSFESKDGTGSSHAGLPPTAAAAYYPYEPALSQYPYDRYGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYGEGEEEEAGEEESREEPLKSAKSEGHAGKDDKELELSDLEDFDPLDAETSECELKTPFQSLDSGPERIPASSDGPGTGKEASTTLRMPLGTAGGAVMDGDLERARNCLRSTVVVPDSGAEGGPPACEAKLTFAQAGAPPNLETKPRIWSLAHTATAAAATALSQTEFPSCMLKRQGPTGVSATTPASSPAVTAPSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRNLGAGTNVLTTPLACSFPPTVPQDVPPAGASRELLATPKAGGKPFCT
What is the function of this protein?
Likely to be an important mediator of ventricular differentiation during cardiac development.
What are the official names of this protein?
Iroquois-class homeodomain protein IRX-4, Homeodomain protein IRXA3, Iroquois homeobox protein 4.
What is the protein family that this protein belongs to?
Belongs to the TALE/IRO homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CIKA_SYNY3
Sequence: MLPAFSPIFRRLLPAVTFERLLRFWRTLAQQTGDGVQCFVGDLPSSLKPPPGPSVLEAEVDHRFALLVSPGQWALLEGEQISPHHYAVSITFAQGIIEDFIQKQNLPVVAEAMPHRPETPSGPTIAEQLTLGLLEILNSDSTSFSPEPSLQDSLQASQVKLLSQVIAQIRQSLDLSEILNNAVTAVQKFLFVDRLVIYQFHYSQPSLTPLEENQIPAPRPRQQYGEVTYEARRSPEIDTMLGIMTENDCFSQVFSYEQKYLKGAVVAVSDIENHYSSSYCLVGLLQRYQVRAKLVAPIIVEGQLWGLLIAHQCHHPRQWLDSEKNFLGQIGEHLAVAIVQSLLYSEVQKQKNNFEKRVIERTKELRDTLMAAQAANLLKSQFINNISHELRTPLTSIIGLSATLLRWFDHPASLPPAKQQYYLLNIQENGKKLLDQINSIIQLSQLESGQTALNCQSFSLHTLAQTVIHSLLGVAIKQQINLELDYQINVGQDQFCADQERLDQILTQLLNNALKFTPAEGTVILRIWKESNQAIFQVEDTGIGINEQQLPVLFEAFKVAGDSYTSFYETGGVGLALTKQLVELHGGYIEVESSPGQGTIFTTVIPQQNFPPTTKGQVQDKLDAAMPFNSSVIVIEQDEEIATLICELLTVANYQVIWLIDTTNALQQVELLQPGLIIVDGDFVDVTEVTRGIKKSRRISKVTVFLLSESLSSAEWQALSQKGIDDYLLKPLQPELLLQRVQSIQQEPLR
What is the function of this protein?
Also functions in a two-component CikA/RpaA output pathway from the circadian clock, negatively regulating kaiBC expression independently of labA and of sasA.  One of three clock output pathways.  Dephosphorylates phospho-RpaA, enhanced by KaiB and KaiC, has only modest kinase activity on RpaA.
What are the official names of this protein?
Circadian input-output histidine kinase CikA.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the phytochrome family.
Protein: RL27_VIBVY
Sequence: MAHKKAGGSTRNGRDSESKRLGVKRFGGESVLAGNIIVRQRGTQFHAGNNVGLGKDHTLFALTDGKVKFEVKGPKNRKFVSIEAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: TILS_THEFY
Sequence: MSGPPPPVALVRTAVRRALRDLPAGSLVLVACSGGPDSLALAGATAFVAPRLGLRAGGVTVDHGLQEGSAERADTVAALLRNLGFDPVERVSVTVGTAGGPEAAARSARYAALEKTADVHQAAAVLLGHTRDDQAETVLLRLARGSGARSLAAMATRTGRYLRPFLDVDRRTVHEAASLMGFEPWSDPHNTDPAYTRSRVRHEALPVLERVLGPGITEALARTATLLRDDADALDAWADQAQQQVGRGPTALDAAGLAGLPRAIRTRLLRRIALAAGCPAGALTAEHVFALDRLVTEWRGQSHVDLPGARRGRRHDGQIIVSAD
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMDH2_HUMAN
Sequence: MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7903306, PubMed:7763314).  Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016).  It may also have a role in the development of malignancy and the growth progression of some tumors.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase 2, IMP dehydrogenase 2, IMPD 2, IMPDH 2, Inosine-5'-monophosphate dehydrogenase type II, IMP dehydrogenase II, IMPDH-II.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytosol. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine- nucleotide depletion.
Protein: Y1389_MYCBO
Sequence: MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
What are the official names of this protein?
Uncharacterized protein Mb1389c.
Protein: NUOI1_RHOP5
Sequence: MKGFGWLEGLLRVGRKLFVKAETVQYPEVRPYLPPRSRGRIVLTRDPDGQERCVACNLCAVACPVGCIDLAKAVAEDGRWYPEHFRINFARCIFCGYCEEACPTAAIQLTPDFELSEWRRDALVYDKHDLLIAGEGKVRGYRYWSVAGKAIQGKDKGEADHEAPPVDLKGLLP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I 1, NADH dehydrogenase I subunit I 1, NDH-1 subunit I 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL23_BARQU
Sequence: MKDLRHYDIIISPVITEKATMISEYNQVAFNVAPKATKPEIKAAVEALFSVKVKAVNTIIRKGKVKRFKGIVGRQSDVKKAIVTLASGQSIDVSTGL
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: UVSE_BACSU
Sequence: MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVTKANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKTHQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGNKDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYANPDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFRQWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS
What is the function of this protein?
Component in a DNA repair pathway.  Removal of UV LIGHT damaged nucleotides.  Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion (By similarity).
What are the official names of this protein?
UV DNA damage endonuclease, UV-endonuclease, UVED.
What is the protein family that this protein belongs to?
Belongs to the uve1/UvsE family.
Protein: MTUS2_HUMAN
Sequence: MSVPVAPKKSCYTQLRDNRNAARNNNESILSLGDTNANQIMLEVSSSHDESKTCDLGDEIGNTNSSEPENRTHFHKEFHQLQGFGKGSQAGSASLKDFRLSSTIQRELNEEHTVERGTDSLQTTRSIQGPSLSSWRNVMSEASLDVLAKRDAEIPRHVPKDKLAKTLDNEELRRHSLERASSSVAAVGSLTPQHPQPLSLDSREARGQIPGGGEGPQKTLPDHAVPAAFPATDSTSEGKSVRHPKPSTSESKQSTPSETQTVGAHVLQVCSEHTSHSAHPEPALNLTLASKEIPSKLEAQLGQGKGEAKLDLKYVPPRRVEQEGKAAQEGYLGCHKEENLSALEGRDPCGEAHPEATDALGHLLNSDLHHLGVGRGNCEEKRGVNPGEQDSLHTTPKQGSASLGGADNQPTGKISPCAGEKLGERTSSSFSPGDSHVAFIPNNLTDSKPLDVIEEERRLGSGNKDSVMVLVFNPSVGENKTEVPEPLDPQSGRSEARESKEVTTSVAENRNLLENADKIESTSARADSVLNIPAPLHPETTVNMTYQPTTPSSSFQDVSVFGMDAGSPLVVPPPTDSARLLNTSPKVPDKNTCPSGIPKPVFTHSKDTPSSQEGMENYQVEKTEERTETKPIIMPKPKHVRPKIITYIRRNPQALGQVDASLVPVGLPYAPPTCTMPLPHEEKAAGGDLKPSANLYEKFKPDLQKPRVFSSGLMVSGIKPPGHPFSQMSEKFLQEVTDHPGKEEFCSPPYAHYEVPPTFYRSAMLLKPQLGLGAMSRLPSAKSRILIASQRSSASAIHPPGPITTATSLYSSDPSADLKKASSSNAAKSNLPKSGLRPPGYSRLPAAKLAAFGFVRSSSVSSVSSTQSGDSAQPEQGRPATRSTFGNEEQPVLKASLPSKDTPKGAGRVAPPASSSVTAPRRSLLPAPKSTSTPAGTKKDAQKDQDTNKPAVSSPKRVAASTTKLHSPGYPKQRTAAARNGFPPKPDPQAREAERQLVLRLKERCEQQTRQLGVAQGELKRAICGFDALAVATQHFFRKNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR
What is the function of this protein?
Binds microtubules.  Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules.  May regulate the dynamics of microtubules at their growing distal tip.
What are the official names of this protein?
Microtubule-associated tumor suppressor candidate 2, Cardiac zipper protein, Microtubule plus-end tracking protein TIP150, Tracking protein of 150 kDa.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the MTUS1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules.
Protein: DAPA_SYNJA
Sequence: MNFGRVLTAMVTPFTPEGELNYEEAARLADYLVTHGSDGLVVCGTTGESPTLTWQEEYELFRVVRDAVAGRAKVIAGTGSNSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYQHFKAIAQASDLPIMLYNIPGRTGVSLQPETVAKLAELETIVAIKEASGIMDAVSEIRRLTPSHFGIYSGDDSLTLPILSLGGSGVVSVASHLVGPQLQELIQSYSRGQHDQALTYHLRLFPLFKALFIETNPVPIKAALEMQGWLVGQVRPPLVPLQGGSLQVLRQVLQEMGLLAEAQGSERRTAKAS
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_ALCBS
Sequence: MSFDHRKYRPVAVIDKPDRRWPNQRIEKAPLWAAVDLRDGNQALIKPMSVAQKRRFFQMLVELGFKEIEVGFPSASQIDFDFCRALIEEDLVPDDVHIQVLTQAREDLIARTFDSLKGAKNAIVHIYNATSPTFREQVFNVDKAGCKAIAVRAAEWVKENAAKQPDTHWSFQYSPETFSATETDFAIEVIDAVNAVWRPDQGQRVIINLPATVEVSTPNVFADQVEMVHDNIQYRDDVIISVHTHDDRGCGVAAAEMAVMAGADRVEGTLLGNGERTGNMDLVTAGMNLYSQGIDPGIDFSRMKEIVALVEEITDIQTHPRHPYAGDLVFSAFSGSHQDAIRKCLARYQEGDIWTAAYLPIDPADVGRRYEEVVRINSQSGKGGVAHVLERDFGIDLPRWLQQELAGVVQGDAEEDGGEITSERVHRRFNSDYLNVPMGWVLRSYDLNRSNEQVQAQISIGDDRQPVTLLSGRGDGAMSALVDALNRRIGGEVKVVSFDEYSLGDNTEANAMACVRVQVGDSTQSAVAMAVDTTAAALQAILSAVGRMQETSEQLIANS
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: YJHH_ECOLI
Sequence: MKKFSGIIPPVSSTFHRDGTLDKKAMREVADFLINKGVDGLFYLGTGGEFSQMNTAQRMALAEEAVTIVDGRVPVLIGVGSPSTDEAVKLAQHAQAYGADGIVAINPYYWKVAPRNLDDYYQQIARSVTLPVILYNFPDLTGQDLTPETVTRLALQNENIVGIKDTIDSVGHLRTMINTVKSVRPSFSVFCGYDDHLLNTMLLGGDGAITASANFAPELSVGIYRAWREGDLATAATLNKKLLQLPAIYALETPFVSLIKYSMQCVGLPVETYCLPPILEASEEAKDKVHVLLTAQGILPV
What is the function of this protein?
Functions as a 2-dehydro-3-deoxy-D-pentonate aldolase.
What are the official names of this protein?
Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_PSYIN
Sequence: MARIAGINVPDHKHAVIALTAIFGIGKTRSQIICAASGIAESTKLKDLDETQIEALRTEVATFTVEGDLRREVSMNIKRLMDLGCYRGLRHRRSLPVRGQRSKTNARTRKGPRKAIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RGYR_THEKO
Sequence: MKAVYREMCPNCWGRISDERLVMRNPCEECLDEPVHADSYFQLVSAVRNALKLRGTLKEWEKIYQLENQTREIEEFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHALKGKKSYIVVPTTPLVIQTVRKIEGIMENANADVRLAYYHGNLRKKEKEEMLERIKNEDYDILVTSAQWLARNYEEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFTDEIIQKAWEIIRLKKQMSRYLNGNSEDRNEKLNGLNREIEKLQREIEKFKRKNKIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTKDIKEHVEELLTRLGKGGLIFVPVDQGLGYAEELANYLSEKGFKIELVSSKNKKALEKFENGEADYLIGSATYYGSLVRGIDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSEEDRRQAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLRDEEVLRKLAEDPFISLVKEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEFKMVPFEELDLDEILRQIDEDREKVRLVMEGKISAKVKDLVRSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEISVGDRMLTILASGGHMFDLVTNEGYHGVLIQNEGDMLKFIPVYDTLKRCRDCGHQFVDWEKKGVCPRCGSTNVRDALENVIAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLAPYTPNIKRIEFHEVTRPAIMKAIQEARDVNENRVNAQIVRRIEDRWIGFELSQELQRVFESYNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTIELGKDGKDVEPPEYVTVEEVQLEERELNPAPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTLVSLADGRIMEIKDAVEKSEGNLLSVNGLKPKEAKALKFWEIDWNGPLKVIKLKNGHEIKATPDHGLLVMREGKLGWVSAKNVREGDYVAFAYNTGHRGRDEYTLLKLMIKLGITDVMVELDEEYFNEKVAPIVRERISTSTKYKYLRRRVLPLYLLQEWGLDDYEAHVKSLYRQRAGSKPIPNFKLDGRFWYVFGLVLGDGTLRDSKVLISQTPLKDVKSVLEDVFPFLRVFETTNQVGFSNSIIAEVFRRLGARKGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNDRKGPNFRGILTSKRGDVLRMLSVYLYQIGIMNYLRRDERTGVWDLIISNRSLEKFREKIYPYLRIRRAQFDEAYSVYRASRRAFEGDLLPVAPVFGKLKFKNGTKNRILKETGIDVWNWLKRPEGEIPRDKLSKVLEYAEESPEKEFLKSLVEAGVTWVKVKGVEEELYTGKLYDFTTTTENFLSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQELGEKYFKPRPWGEEGAHEAIRPTRPIDTGRLMQLIRDGIIQLPRNLTRNHYRLYDMIFRRFMTSQMTPAKILYEKAVINAGVGKAELEGYVEIIEDGWTRLRSPPLRELPKLEKGMKLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVETLMRRGYVVETKGRKKLLPTEKGIKVYHYLVSKYRDLVSEERTRELEEIMDRIEEGIEDYIKVLGELYSEIQRYVSG
What is the function of this protein?
Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process.  It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue.  May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity).
What are the official names of this protein?
Reverse gyrase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
Protein: PDXT_LISMH
Sequence: MKKIGVLAIQGAVDEHIQMIESAGALAFKVKHSNDLAGLDGLVLPGGESTTMRKIMKRYDLMEPVKAFAKEGKAIFGTCAGLVLLSKEIEGGEESLGLLDATAIRNGFGRQKESFEAELSVDVFDAPTFEAIFIRAPYLIEPSDEVTVLATIDGKIVAAKQANILVTAFHPELTNDNRWMRYFLEKIL
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.