PharMolix/UniProtQA huggingface dataset:
Protein: METK_METEP
Sequence: MPRSDYLFTSESVSEGHPDKVSDRISDTVVDAYLSAMPEARLGVETLTTTNRVVIAGEVRGPDSVTFKDLEELTREAVRDIGYEQSGFHWKNNDVAIHLHAQSADIAQGVDAAGNKDEGAGDQGIMFGYAADETPALMPAPIFYAHKILKDLADARKAKQGDAAKLGPDAKSQVTVRYANGRPVEVTQIVLSTQHLDESLDSADVRAIVEPYILKALPQGWVNEGTVWHVNPTGKFVIGGPDGDAGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYAARYLAKNVVAAGLARRATIQLSYAIGVAKPLSIYVDLHGTGTVDEAKLETVLMDALDLSPRGIRTALQLNKPIYARTSAYGHFGREPDADGGFSWEKTDLADKLKSAF
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_SYNJA
Sequence: MSRYTGPRLKIIRRFGGLDLPGLTRKRPKNTNPPGMHGAERKKKSEYAIRLEEKQKVRLNYGVSERQMLRYMRKARRSKGSTGLALLQMLEMRLDCIVFRLGMAPTIPAARQLVSHGHIEVNGRKVTIPSYGCKVGDVITVRNKESSRKLVAAYAEYPGLFLPDYLEFDKEKLRGRIKELPPREQICAPVNELLVVEFYSRKL
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RASL3_HUMAN
Sequence: MDPPSPSRTSQTQPTATSPLTSYRWHTGGGGEKAAGGFRWGRFAGWGRALSHQEPMVSTQPAPRSIFRRVLSAPPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQEAPELEPEPELEPPTPQIPEAPTPNVPVWDIGGFTLLDGKLVLLGGEEEGPRRPRVGSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQVHNVRGLLKRLKEKKKARLEPRDGPPSALGSRESLATLSELDLGAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFHFEALPPARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWFPLLGAPAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDTLEPLPTILRAIEEGQPVLVSVPMRLPLPPAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRARPWTRDSASLPRKPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAALREEQKVLSRLVESLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEHNLTSNEGHSLKNLEHRLNEMERTQAQLRDAVQSLQLSPRTRGSWSQPQPLKAPCLNGDTT
What is the function of this protein?
Functions as a Ras GTPase-activating protein.  Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway.
What are the official names of this protein?
RAS protein activator like-3.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cell cortex.
Protein: PCAK_PSEPU
Sequence: MNQAQNSVGKSLDVQSFINQQPLSRYQWRVVLLCFLIVFLDGLDTAAMGFIAPALSQEWGIDRASLGPVMSAALIGMVFGALGSGPLADRFGRKGVLVGAVLVFGGFSLASAYATNVDQLLVLRFLTGLGLGAGMPNATTLLSEYTPERLKSLLVTSMFCGFNLGMAGGGFISAKMIPAYGWHSLLVIGGVLPLLLALVLMVWLPESARFLVVRNRGTDKIRKTLSPIAPQVVAEAGSFSVPEQKAVAARSVFAVIFSGTYGLGTMLLWLTYFMGLVIVYLLTSWLPTLMRDSGASMEQAAFIGALFQFGGVLSAVGVGWAMDRYNPHKVIGIFYLLAGVFAYAVGQSLGNITVLATLVLIAGMCVNGAQSAMPSLAARFYPTQGRATGVSWMLGIGRFGAILGAWSGATLLGLGWNFEQVLTALLVPAALATVGVIVKGLVSHADAT
What is the function of this protein?
Transports 4-hydroxybenzoate (4-HBA) and protocatechuate across the membrane.  Driven by the proton motive force.  Functions also as a chemoreceptor, which is required for chemotaxis to aromatic acids.
What are the official names of this protein?
4-hydroxybenzoate transporter PcaK.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2.A.1.15) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MINC_PSELT
Sequence: MTIDLIDFKMTKEGLVLVIKDYDNLEDVVNQLTSKISQMSGFFAAGDKIMLMIENNEKHSHDMPRIISILKKMGIEVSQILMGVTAKEGINVRGRMKMVEEGETKSGTKVVKKNLRSGQALVHSGDVIVIGNVHSGAEIMAGGSIVVFGNVKGILRAGLNESDSIVAALSMEPSLIQISEYILREAGSYDEPVVVHVKQNKIVIESAKDVKFQ
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: PG161_MONPV
Sequence: MMTPENDEEQTSVFSATVYGDKIQGKNKRKRVIGLCIRISMVISLLSMITMSAFLIVRLNQCMSANKAAITDSAVAVAAASSTHRKVVSSTTQYDHKESCNGLYYQGSCYILHSDYKSFEDAKANCAAESSTLPNKSDVLTTWLIDYVEDTWGSDGNPITKTTSDYQDSDVSQEVRKYFCT
What is the function of this protein?
Forms a complex with OPG162 and OPG190 to coordinate the incorporation of OPG164 into wrapped enveloped virion (EV) membranes and, subsequently, the production of actin tails.  Therefore plays an essential role in efficient cell-to-cell spread of viral particles.
What are the official names of this protein?
Protein OPG161.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG161 family.
Protein: RON_HUMAN
Sequence: MELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVTYEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDTKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDCRFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCGYINSHITICGQHLTSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTVGGESCQHEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLGILLPLLLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQFSPMPGNVRRPRPLSEPPRPT
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand.  Regulates many physiological processes including cell survival, migration and differentiation.  Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1.  Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site.  Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages.  Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
What are the official names of this protein?
Macrophage-stimulating protein receptor, MSP receptor, CDw136, Protein-tyrosine kinase 8, p185-Ron.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: OBG_AZOSB
Sequence: MKFFDEARIEVVAGDGGNGAATFRREKFIPRGGPDGGDGGRGGSVYAVADRNLNTLVEYRFKRSFRAERGENGGSKDCYGKGGEDITLHFPVGTVISDLDSGEPIADLDVDGKRVLLAQGGRGGLGNLHFKSSVNRAPRKRTMGQEGERRNLHLELKVLADVGLLGMPNAGKSTFIRAVSAARPKVGDYPFTTLQPNLGVVRTDENRSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTHVLLHLVDLAPFDPEVDPVRDALAIVEELRKYDESLYNKPRWLVLNKLDLLEPEDRAPRVAAFLEAYGEVERHFEISALQGEGCRGLIFALQDFLDSERANIHAQQAAREAEERQRLAAAQSARSAAEAEALEADLAEDALAEDALAEDALAEDALDDDADGEDADPNAR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_STRPM
Sequence: MTNSFQNSRRDLRERAFQALFNIEMGAELLAASQFAYGYDKVTGEDAQVLELPIFLLSLVTGVNNHKEELDNLISTHLKKGWSLERLTLTDKTLLRLGLFEIKYFDETPDRVALNEIIEVAKKYSDETSAKFINGLLSQYVSEAPSANKS
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RL20_ZYMMO
Sequence: MARVKRGTTTRAKHNRILDQAKGYYGRRKNTIRIARQAVEKAGQYAYRDRKVKKRSFRALWIQRINAAVRAEGLTYGVFMYGLKLAGLDLDRKVLADLAMNESAAFGAIIAQVKSALPEGARVAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NSUN6_PYRHO
Sequence: MAMNYLEAFPKELREYYKNLFGKEEANKIMKKLREPVEHYYIRVNTLKISREKLIGELKKEGLKPLRSPYLPEGLYFVREGPNFSDDFEPKLPVVVANKYAAESVYQGAMLYAPGVLKADKNIKEGDEVQIRDPKGLLVGIGIARMDYKEMTEATRGLAVEVTLPKFKLPSLSELKAFEKGYFYPQGLPSMVTARVLEPKEDDVIIDMAAAPGGKTTHIAQLLENKGEIIAIDKSKNRLRKMEENIKRLGVKNVKLVQMDARKLPDLGIKADKILLDAPCTALGVRPKLWEERTLKHIEATARYQRAFIWAAIKSLRRGGVLVYSTCTLSYEENEGNVKFMIRKGMKLEEQSIFIGSPGIGMNKVQRFYPHKHLTQGFFIAKLRKVKDI
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.  This modification appears to slightly promote the thermal stability of P. horikoshii tRNAs, but does not affect their amino acid accepting activity.  Four elements in the acceptor stems of tRNAs are essential for substrate recognition by this enzyme: the target site C72, the 3'-CCA terminus, U73 or G73, and the second base pair C2:G71.
What are the official names of this protein?
tRNA (cytosine(72)-C(5))-methyltransferase, tRNA:m(5)C72 MTase, PhNSun6.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Protein: LIVH_ECOLI
Sequence: MSEQFLYFLQQMFNGVTLGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTGWLLVAAGFVGAIVIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQNYVSLTEGSRDVALPSLFNGQWVVGHSENFSASITTMQAVIWIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGMKAFTAAVLGGIGSIPGAMIGGLILGIAEALSSAYLSTEYKDVVSFALLILVLLVMPTGILGRPEVEKV
What is the function of this protein?
Part of the binding-protein-dependent transport system for branched-chain amino acids.  Probably responsible for the translocation of the substrates across the membrane.
What are the official names of this protein?
High-affinity branched-chain amino acid transport system permease protein LivH, LIV-I protein H.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL36_ENTFA
Sequence: MKVRPSVKPMCEHCKVIRRKGRVMVICPANPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: Y337_SPHAL
Sequence: MAGHSKFKNIMHRKGAQDKKRSALFSKLSREITVAAKMGLPDPDANARLRAAVNAAKAQSMPKDNIQRAIDKASGGDGDNYEEIRYEGYGPGGVSLIVEALTDNRNRTATNVRTAFSRNGGNLGTSGSVSHGFDRLGLISYPPGVGDADTVFEAALDAGADDVESSDDGHDIWTSIDSLHEVAKALEAKLGEAEGVKLAWRPTMKSEVADEATAQTLFKLIDTLDDDDDVQTVWGNYEIPDAVMEKLG
What are the official names of this protein?
Probable transcriptional regulatory protein Sala_0337.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_HELPH
Sequence: MAKRCALTFKGPMVGNHVSHANNKNKRRSLPNLRSIKIQLDDGTTKRIKVAASTLRTMRKGA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: TRADD_BOVIN
Sequence: MAAGPNGLEEWVGSAYLFVESSLDKVVLSDAYAHQQQKVAMYGALQTALAESGGSPDVLQMLKIHRSDPQLIVQLRFSGRQACSRFLRAYREGALRATLQGCLARALALNSVPLQLELRAGAEQLDALLTNEERCLNCICAQKPDRLRDEELTELENALRNLTCGSAGGQGSDVQGTPAPLQSLAPSPPEEKPPPPQPGQTFLFQGQPIVNRPLNLQDQQKFARSVGLKWRKVGRSLQRSCRALRDPALDSLAYEYERDGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLANPDGSLA
What is the function of this protein?
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD.  Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity).  The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity).
What are the official names of this protein?
Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus.
Protein: PUR7_CHESB
Sequence: MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEYIFEHLNRIGIPTHFIRRLNMREQLIKEVEIVPLEIVVRNIAAGSLAKRLGIEEGTVLPRSIIEFYYKADALDDPMVSEEHITAFGWASPQEIDDIMALSIRVNDFLTGLFLGVGIQLVDFKIECGRLWEGDMMRIVVADEISPDSCRLWDINTRDKLDKDRFRRDMGGLVEAYQEVARRLGIMNENEPPKPAGPVLVSSKPDGETRH
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RNFE_EDWI9
Sequence: MSEAKNLFINGLWKNNSALVQLLGLCPLLAVSSTATNALGLGLATTLVLVLTNSAVSALRRWVPGEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVIGRAEAYAAHHPVGMAALDGLATGLGATAALFVLGALREILGNGTLFDGADLLLGHWARALRIELFHTDTPFLLAILPPGAFLGLGFMLAFKYVIEQKRRQRQAQRSAVGQALRGAAPTDNHEQA
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENOPH_DROWI
Sequence: MLGNEIKVILLDIEGTTTSIGFVHHILFPYAKQNVEEYLKKEWDSDEIKQIVQDLQQVPSFEVYKATLVDSSASSITVELITGFVRYLIDKDLKVTPLKTLQGLIWANGYESGELKGHVYDDVKEAFEHWNNSGLKLAIYSSGSVAAQKLIFGYSTSGNLLPYLSAHFDTHVGHKQEKDSYINIAKSLETNPEHILFLTDIPGEADAARAAGLQAIILQRFGNAPLTDDEKSLNKIINDFSVLKVDK
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS10_BORDL
Sequence: MITKDKIRVRLFSFDVKILDQSAESIVRAVQKSKAQIKGPIPLPTKIKKYTVLRSPHVNKKSREQFEMRTHKRLIDILEPTSALMDSLMKLELPAGVEVDIKQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: URE1_MORMO
Sequence: PQISRQEYGGLFGPT
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_BURP0
Sequence: MVIIRLARGGSKKRPFYNIVATDSRNRRDGRFIERVGFYNPVATKGEALRIAQDRLTYWQGVGAQLSPTVERLVKQAQKAQPAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RL331_MYCGA
Sequence: MAQKRGTRLGCNDCNEINYITRKNAKKNPEKLSLNKYCSRCRGTTVHKEVKRK
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: GCH1L_YERPE
Sequence: MRNVELETVLNNQLNIGAFQDYAPNGLQVEGRRDIQRVVTGVTASQALLDAAVAHQADAILVHHGYFWKNEPVVVRGMKRNRLKTLLTHDINLYGYHLPLDAHPELGNNAQLAKLLEIQVLGEIESLLPYGEFTTPLNAVALRERLEKQLGRSVLHCGDRAPAEVRRIAWCTGGGQGYIQQAAEFGVDAFITGEVSEQTIHIAREMKVNFYAAGHHATERYGIKALGEWLAEQYQLDVTFIDIPNPA
What are the official names of this protein?
GTP cyclohydrolase 1 type 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
Protein: G3P3_MUCCL
Sequence: MSTINTGINGFRSHWPYCLACSLENPKVKVVAINDPFIDLEYMVYMFKYDSTHGRFKGTVEHKDGKLVVNGHEIAVHAERDPAQIPWGSHGADYVIESTGVFTTKDAASAHLKGGAKKVIISAPSADAPMFVVGVNLDKYTSDLTVISNASCTTNCLAPLAKVIHDNYGILEGLMTTVHATTATQKTVDGPSNKDWRGGRGAGANIIPSSTGAAKAVGKVIPELNGKLTGMAFRVPTPDVSVVDLTVRLEKPASYDEIKATIKKASESEELKGILGYTEDQVVSTDFVGDAHSSIFDAKAGIQLSPTFVKLISWYDNEFGYSTRVVDLLAYVAGKDGAL
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 3, GAPDH 3.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASCJ_ACREG
Sequence: MTDIHIQDGDLSSLKDKVVVITGGSSGIGLATTNLLLDLGAKVVIGDLQPPTTRVDSERCSFHKVDVTVWSDQLTLFKEARELHGRIDHVFANAGVGPKADYLSTALDQNGDLVEPTFLTLDVNLKAVIYTATIACYYMREEQQSPAGGSIVIVSSVAGVSRFRAVDYATAKHGNLGFARGLHQRLTAENSPTRVNLIAPSWTNTGFMPPQIMAAVGVEPQEPASVGRAAAYLMADDSRKGQMIHIAKGRYREVEESIMLPAAEKVVDVENGGVMEDDTLAKIIETMGIFKAKATQ
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the asc-2 gene cluster that mediates the biosynthesis of ascofuranone, a strong inhibitor of cyanide-insensitive alternative oxidases and a promising drug candidate against African trypanosomiasis (PubMed:30952781, PubMed:35418536).  The first step in the pathway is performed by the non-reducing polyketide synthase ascC that produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:30952781, PubMed:35418536).  Orsellinic acid is then prenylated by the prenyltransferase ascA to yield ilicicolinic acid B (PubMed:30952781, PubMed:35418536).  Ilicicolinic acid B is further reduced to ilicicolin B by the reductase ascB (PubMed:30952781, PubMed:35418536).  The halogenase ascD then chlorinates ilicicolin B to produce ilicicolin A which is converted to ilicicolin A epoxide by the cytochrome P450 monooxygenase ascE that catalyzes stereoselective epoxidation of the terminal double bond of the prenyl group (PubMed:30952781, PubMed:35418536).  Ilicicolin A epoxide is the last common precursor for the biosynthesis of ascofuranone and ascochlorin (PubMed:30952781, PubMed:35418536).  The terpene cyclase ascF produces a monocyclic terpene, and the cyclization reaction is proposed to be initiated by protonation of the terminal epoxide of ilicicolin A epoxide to generate a monocyclic tertiarycation, which is followed by a series of hydride and methyl shifts with abstraction of proton, leading to the formation of the (14S,15R,19R)-trimethylcyclohexanone ring structure of ilicicolin C, which is finally reduced to ascochlorin by the dehydrogenase ascG (PubMed:30952781).  On the other hand, ilicicolin A epoxide is hydroxylated by the cytochrome P450 monooxygenase ascH, and the resultant product is cyclized by the terpene cyclase ascI to ascofuranol via protonation-initiated epoxide ring opening, which facilitates the 6-endo-tet cyclization to form the tetrahy-drofuran ring (PubMed:30952781, PubMed:35418536).  Finally, ascofuranol is oxidized into ascofuranone by ascJ (PubMed:30952781, PubMed:35418536).
What are the official names of this protein?
Short-chain dehydrogenase/reductase ascJ, Ascofuranone/ascochlorin biosynthesis clusters protein J.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: SNU71_VANPO
Sequence: MSNRDIVYVSPQAYLSSSQDWCLNSQQKGYIPILQNDLLNFKKILDLKKPKTTSINRDHENVASSNSKNSNTNHLGENNASTNGNNLNLQNLNDNINNNDVEKLSYQNMKLFHPISTIDQLYTVSLVGVPTALSDITLETIFKSISNDNVLSWSAFVSAVLDSKIVYLRFKSTLSKIEFKKTLLSIQSILESKDINLGELHYDSNVKDFLNSIDLKNEPIPNTSQEKLINTLVKIISENVPNSNDTKNKIDSDHPESYEIDLGTLSDIPSDSIEQLCKDIIDFRTKVIKIEREKKIKQSLEESRLSKQKLDKIFNQIKKTRNLTPIDSTKSMEGGVLAATATEEEARDDYEEEEDEDEDEEDDLKILNKSIAQEKEESNQRYLMLLNNLNKSIEPNLKKLSHSVLESTNYLDIITSNRSLFNKELQILSTDVYYDHNTSFRQEEIRKDDIDRELNPHVKLITTESIMSKSVEESKESLDKNEQASKSIITQNENISVTSDIKIKLAFKTKIDKSSEIYSSSETESDEEIKHLQTSIRESKNKTTDIVTSSGKDNSILTFTDDELQKRLTQLRESKIVDELVNEYLGVYEDELVDYIFDNIKENKNKHLLLVDLKETFDDDAIKIVDTIWKHQAMLP
What is the function of this protein?
Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA.  Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (By similarity).
What are the official names of this protein?
U1 small nuclear ribonucleoprotein component SNU71.
What is the protein family that this protein belongs to?
Belongs to the SNU71 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.