PharMolix/UniProtQA huggingface dataset:
Protein: RS9_VIBC3
Sequence: MAENQYYGTGRRKSSAARVFIKPGSGNIVINKRSLEEYFGRPTSCMVVKQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRPVLRAAGYVTRDARRVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: XYLA_AGRVS
Sequence: MSTGFFGDITKIKYEGPDSTNPLAFRHYNPDEVVMGKRMEDHLRFAVAYWHTFVWPGTDPFGGNTFERPWFKDSMEAAKLKADVAFEFFQLLGTPYYCFHDADARPEGASFAENTKNLNEIVDYFAQKQADTGVKLLWGTANMFSHRRYMSGAATNPDPDVFAFAAATVKTCLDATQKLGGENYVLWGGREGYETLLNTDLKQELDHMGRFLNMVVEYKHKIGFKGAILIEPKPQEPSKHQYDYDVATVYGFLKTYGLEKEVKVNIEQGHAILAGHTFEHELALANALGIFGSIDMNRNDYQSGWDTDQFPNNVPEMALAYYQVLQAGGFTSGGTNFDSKLRRQSIDPADLLIGHIGGMDCCARGLKAAAKMVEDKALSGPLANRYAGWNSDGAKAMLASGTLESIAARVEGENINPQPVSGQQELLENVVNRYV
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_KLEP3
Sequence: MIDFSNFYQLIAKSPLSHWLETLPAQVAAWQREALHGKFREWERAVEFLPELTPWRLDLLHSVTAESETPLSEGHQLRVENLLKNLMPWRKGPYSLYGINIDTEWRSDWKWERVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALEAFDTVFSMGVLYHRRSPLDHLWQLKDQLAPGGELVLETLVVEGDENTVLVPGDRYAQMRNVYFIPSAAALKMWLEKCGFIDVRIVDACVTSTDEQRRTEWMTSESLADFLDPQDQRKTVEGYPAPLRAVIIATKPETQQSLAKKAR
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: MIAA_DESVM
Sequence: MSLSDNFADSLISAPPIRVICLVGPTGAGKTAAALHLARTFGGGVVNADSRQVYRDFPVITAQPSPEERAVCPHLLYGFLPSTEKISAGVWTDKATVVIEELCREEPGHNTSRQATSRPDGLVPLLVGGTGLYLKTLLDGIADIPRVDPAIGARLERECDALGAPALHARLASIDPDYAARIHPNDRQRAVRALEVHEGTGHALSWWHARPVPRPRYAALRIGMDMSLDELTPRLDRRIDLMLEAGALDEARAARTVCDDPAAPGWSGIGCAELYRYLTGELPWAEARLLWLRNTRAYAKRQLTWFRADKRIHWVRPDDLDAMAALACAFLRGETAE
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: APJA_XENLA
Sequence: METEGLSPMLYEDDYYYGNETGLQPCDETDWDFSYSLLPVFYMIVFVLGLSGNGVVIFTVWKSKPKRRSADTYIGNLALADLAFVVTLPLWATYTALGFHWPFGSALCKLSSYLVLLNMFASVFCLTCLSFDRYLAIVHSLSSAKLRSRSSIIVSLAVIWLFSGLLALPSLILRDTRVEGNNTICDLDFSGVSSKENENFWIGGLSILTTVPGFLLPLLLMTIFYCFIGGKVTMHFQNLKKEEQKKKRLLKIIITLVVVFAICWLPFHILKTIHFLDLMGFLELSCSTQNIIVSLHPYATCLAYVNSCLNPFLYAFFDLRFRSQCFFFFGFKKVLQGHLSNTSSSLSAQTQKSEIHSLATKV
What is the function of this protein?
Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:17412318, PubMed:16750822, PubMed:16876154).  Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (By similarity).  Promotes angioblast migration toward the embryonic midline, i. e.  the position of the future vessel formation, during vasculogenesis (By similarity).  May promote sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity).  Required for cardiovascular development, particularly for intersomitic vein angiogenesis by acting as a receptor for apln hormone (PubMed:17412318, PubMed:16750822, PubMed:16876154).  Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure (By similarity).  Acts upstream of the i/o type of G-alpha proteins in the differentiation of endothelium, erythroid cells, myeloid cells and cardiomyocytes (PubMed:16876154).
What are the official names of this protein?
Apelin receptor A, Angiotensin receptor-like 1a, xAngio1, Angiotensin receptor-related protein A, G-protein coupled receptor APJ-A, APJa, Mesenchyme-associated serpentine receptor, x-MSR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to apelin (apln) (PubMed:17412318). After exposure to apelin receptor early endogenous ligand (apela), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity).
Protein: HEL2_SCHPO
Sequence: MSPSGPNLNNKEHNRASEKKNSRTHNKKTNRNQSKEKPVSSRSVETPKNAVCLEPVGTDPVSNVATVDASKEEQDEDEQICFICAEGITYSCVLPCNHRMCHVCALRLRALYKTKECTFCKTEWDTVLITKDHEIDIHDVDLAKLPFQDEKLGIVYSDEHAQEESNLLLQFNCPEDACDITCKGWFDLKLHAKVKHHKFFCDLCVKNKKVFTHEHTLFSKKGLTKHNEVGDQGSDLEITGFKGHPKCEFCNTHFYDDDELFKHCREKHERCYICDQVAGRPTHQYFKNYDSLERHFEKDHYICRERECLERKFVVFGTEIDLKAHQLDEHPHNFTQRELREARRIIPQFSYDPPGASGRNRRERTSSTPSEQSTSVNETANSLSNLHLSRGEIAHLRQEEYVREQQARHRDFGFTLSNPAPTSARPATSTRTISRGKTRTLRNEDFPSLAEVANQNSSSAPSVPVSAPRLSGKSASRNHVPSPPKGTKSPMASSEQAQHQQVIDRMQKLTNYDDHKINDFKFAVSSFRGNVMPAREAVARITKLVAKPHEQLSGVFNQIANLLENKEKSRELLEAWQEWKILNAKDDTRIGTTNSNLLRLKRSNRTAAQTASVWNRIERAAAHDGPSLSAPSSSINLANITSRPTNSSAANTPSWGVRKARASALNARSEEDFPALPPSTSKRISVQLGKKQARPVDSWGSTPNTSSNRNSNTMGVSKKKNGKKQTVLFHIG
What is the function of this protein?
Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones.  Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase hel2, Histone E3 ligase 2, RING-type E3 ubiquitin transferase hel2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_STRPM
Sequence: MDYSEIMVRHGELSTKGKNRMRFINKLKNNIQDVLAPFPAIAVRSDRDRTHVSLNGTDYQPIVEALKLVFGVQALSPVYKLEKSVPLLVTAVQDIMTSLYRDGLTFKIATKRSDHAFELDSRELNSLLGGAVFEVLPNIQAQMKHPDVTLKVEIRDEAAYISYEEIKGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGLDIEVVHFASPPYTSPGALAKAQDLTRRLTRFGGNIQFIEVPFTEIQEEIKNKAPEAYLMTLTRRFMMRITDAIREQRKGLVIVNGESLGQVASQTLESMQAINAVTSTPIIRPVVTMDKLEIIEMAQAIDTFDISIQPFEDCCTIFAPDRPKTNPKLGNAEKYEERFDIDGLVQRAVSGIVVTEITPEIVNDEVENLIDALL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABIL4_ARATH
Sequence: MASSTSLAIVLHQSSNHDELFMKQTLQFSETLKDLKNLRKQLYSAAEYFETSYGKAEHKETVIETLKEYAAKAVVNTVDHLGSVSDKFNSFLSDNSTHFSTTHLRLSSLEQRMRLCRDYMGKSGTHQHLLLFQYPRHHKRYFFPQQGRGTSFSAGDDSHRFTSAVRSTILENLPNTARKANKTGSFSFAPIVHNNINNRTPNKRSNSPMRFPLLRSGSLLKRSSSPSQPKKPPLALPEPQRAISVSRNTEIVEIKQSSSRKGKKILMFKALMSMSKSRN
What is the function of this protein?
Involved in regulation of actin and microtubule organization.  Part of a WAVE complex that activates the Arp2/3 complex (By similarity).
What are the official names of this protein?
Protein ABIL4, Abl interactor-like protein 4, AtABIL4.
What is the protein family that this protein belongs to?
Belongs to the ABI family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: OST4_DROSI
Sequence: MITDMQLAIFSNVLGVFLFLLVVAYHYINANTGKPSAKAK
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the OST4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: HSLV_ENTFA
Sequence: MVESQFHSTTICAVEKDGKFAMAGDGQVTMGESVVMKGTAKKVRRIYNDEVVVGFAGSVADAFTLEEKFEGKLNEYNGNLTRAAVELAQEWRTQQSMQKLEAMLIVMNKEEMLLVSGTGEVITPDDGILAIGSGGNFALSAARAMKNFGDKEMPAKEIAKNALNIAADICVFTNHNIIVEEL
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN_THEVO
Sequence: MGTDISDIVVSHQTSLKDQANQVFAIDTYNILYQLLSNVRQYDGTPLMDSSGNVTSHLYGIFYRTVNLVENGIKPIFVFDGKPSPLKNRTLEIRQLAKEKAKAELEEAISRGEENLKQYYSRINYITPQIVNDTKELLTYMGIPYVDAPSEGEAQASYMTRKDADGVISQDYDCLLFGAKKILRNFAIYGRRKVPRKNVYRTVYPEYVMLDEVLKKNGINQDQLIEIGILVGTDFNEGIKGIGAKKALALIKKEGNIKAVLNKIGKNIENLDEIIDFFKNPPVVDVKYVFGKPDPKKIEEFLCVVHDFSRDRILEHINTYVKYYNKSVQFRLDSF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: SP2G_BACSU
Sequence: MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGSSIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGIIGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQYEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIRNTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKCLIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS
What is the function of this protein?
Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation.  Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.
What are the official names of this protein?
Sporulation sigma-E factor-processing peptidase, Membrane-associated aspartic protease, Stage II sporulation protein GA.
What is the protein family that this protein belongs to?
Belongs to the peptidase U4 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localized to the sporulation septum.
Protein: ZBT42_MOUSE
Sequence: MEFPEHGVRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDQPASSRDTVRLNGDIVTVPAFSRLLDFMYEGRLDLHNLPVEDVLAAASYLHMYDIVKVCKGRLRKKDPDLETRTLGTELPGQPPHPLPSWSPAFCQAAPKAKHPSLGVKATHPLPTFGPPSWQVAEQSSGALDLSLKPSPRPEQVHPPCRLQTSLCSSVQQVAQPLVKAEQDSFSEQDSSSPQSADRSPPPVCASAAQGLAVDLEPLHIEGTGSQQLGLPAEPVLDSEELGPSRHLCICPLCCKLFPSTHALQLHLSAHFRERDSVRARLSPEGSVPTCPLCSKTFSCTYTLKRHERTHSGEKPYTCVQCGKSFQYSHNLSRHAVVHTREKPHACRWCERRFTQSGDLYRHVRKFHYGLVKPLLV
What is the function of this protein?
Transcriptional repressor.  Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 42, Protein simiRP58.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm. Note=In skeletal myofibers, highly enriched in subsynaptic nuclei at the neuromuscular junctions.
Protein: MACB_SHESA
Sequence: MSKPLLEVSACYRSFQAGEQQLTVLKDINLSIARGEMVAIVGASGSGKSTLMNILGCLDKPSKGSYFIDGQDTSQMDVDELAKLRREHFGFIFQRYHLLGDLNAVGNVEVPAVYAGKDRLERRERAESLLSRLGLGERLDHKPNQLSGGQQQRVSVARALMNGGDVILADEPTGALDSHSGEEMMRLLQELHREGQTIIIVTHDMHVAQHADRIIEIKDGVIISDEPNPASNIAAAPKTEVIPAKTKARARVAAWDRYAEALKMALLAMSTHRLRTFLTMLGIIIGIASVVSVVALGEGSQREILKSISSMGTNTIDIRPGSGFGDRRSARVRTLTASDANALKNLPYVDSVTPSIGSSATVRYGNKAVTATVNGVGPEFFRVRGYELAQGQFWDDDSVNALAQDAVIDENTRKQLFPNSSGAMNSAIGEVIFLGDLPVRIIGVTQPKESAFGNSDALNVWVPYTTVSGRMVGKKYLDGITVRLDESVPSNAAEQGIISLLKMRHGTQDFFTINTDTIRQNIEKTTATMTLLISAIAVISLVVGGIGVMNIMLVSVTERTREIGVRMAVGARQSDILRQFLIEAVLVCLCGGALGVALAYLIGVVFAQAGGSFQMIYSTTSIVAAFACSTLIGVLFGFLPARNAARLDPVDALARE
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SWET4_ORYSI
Sequence: MVSPDTIRTAIGVVGNGTALVLFLSPVPTFIRIWKKGSVEQYSAVPYVATLLNCMMWVLYGLPAVHPHSMLVITINGTGMAIELTYIALFLAFSLGAVRRRVLLLLAAEVAFVAAVAALVLNLAHTHERRSMIVGILCVLFGTGMYAAPLSVMKMVIQTKSVEYMPLFLSLASLVNGICWTAYALIRFDLYITIPNGLGVMFAVAQLILYAIYYKSTQQIIEARKRKEADHVAMTDVVVDSAKNNPSSGAAAAAANGRY
What is the function of this protein?
Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.
What are the official names of this protein?
Bidirectional sugar transporter SWEET4, OsSWEET4.
What is the protein family that this protein belongs to?
Belongs to the SWEET sugar transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FGF21_HUMAN
Sequence: MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPALPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS
What is the function of this protein?
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression).  Activity requires the presence of KLB.  Regulates systemic glucose homeostasis and insulin sensitivity.
What are the official names of this protein?
Fibroblast growth factor 21, FGF-21.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted.
Protein: COAD_FRATT
Sequence: MNKIAIYPGTFDPITNGHVDLVERALNIFDEIVVAVSTAYGKNTLFDIRIREQMIKEVFKDNQRVKVVSFQGLLVDTAVKHNACAIVRGLRAVSDFDYEFQMSSMNNKLNSDIQTIFLTPSEKFSCISSTLVRAVAIHNYKRVDEFVPECVFREIKLKYSKE
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I76AB
Sequence: MNPNQKIITIGSVSLTIATICFLMQIAILVTTVTLHFKQYECDSPANNQVMPCEPIIIERNITEIVYLTNTTIEKEICPKLVEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNDTIHDRTPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCVTGYDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTKILFIEEGKIVHTSPLSGSAQHVEECSCYPRYPGVRCICRDNWKGSNRPVVDINVKDYSIDSSYVCSGLVGDTPRKNDRSSSSYCRNPNNEKGTHGVKGWAFDDGNDVWMGRTISEDSRSGYETFKVIGGWSTPNSKLQINRQVIVDSNDRSGYSGIFSVEGKSCINRCFYVELIRGREQETRVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: PURA_PICST
Sequence: MCDVVLGSQWGDEGKGKLVDLLCDDIDVCARCQGGNNAGHTIVVGDVKYDFHMLPSGLVNPNCLNLVGSGVVVHVPSFFQELENLEKKGLNCRDRLFLSSRAHLVFDFHQRTDKLKEAELSENKKAIGTTGKGIGPTYSTKASRSGIRVHHLVSEDPEAWEEFKTRYHRLVNSRKQRYGEFDYDVEEELARYEKYRELLRPFVVDSIEFMHTALVQNKRILVEGANALMLDIDFGTYPYVTSSSTGIGGVLTGLGIPPKTINNIYGVVKAYTTRVGEGPFPTEQLNEFGEALQTIGAEYGVTTGRKRRCGWLDLVVLKYSTLINGYTSLNITKLDVLDSFKEIQVGVGYKLNGKSLASFPEDLIKLGKVEVEYKTLPGWETDITKIKTYDELPENAKSYLKFIEDYLGVPVQWVGTGPARDSMLEKPISK
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCKI_MESMA
Sequence: MKIFFAVLVILVLFSMLIWTAYGTPYPVNCKTDRDCVMCGLGISCKNGYCQGCTR
What are the official names of this protein?
Neurotoxin BmP08, Short-chain peptide BmKX.
What are the subcellular locations of this protein?
Secreted.
Protein: TAL_CLOK1
Sequence: MKLFIDTANVDEIRKANDMGIICGVTTNPSLIAKEGRNFKEVVKEITDIVDGPISAEVISLEWKEMVKEARELVKIHKNIVIKIPMTQEGLKAVKVLSQEEIKTNVTLIFSAAQALLAAKAGASYVSPFLGRLDDVGMDGIKLIEEIVTIFKVQNIVTEIIAASIRGPIHVVKCAALGSHIATVPYKVLVQMCKHPLTDIGIERFLKDWESVPDK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_WIGBR
Sequence: MKEKNSNKINEDKLNKKSEVKNKKEEEIINNKKQTTEKKINLNKNNISDEIIPEKINFNDQKNIIENLKKNLSKEKKSKHDLILRNQAEMENLMKRTQANIEKSYKFALEKFSIALLPIIDNLERTKNLLEKENEKNKNINPIEEGINLTLKEFIKVIHSFGIKEIDKKNIPFDPKIHEAMTVIDDKNKKTNQVVEIMQKGYILNGRLLRPAMVVVSK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN556_HUMAN
Sequence: MDTVVFEDVVVDFTLEEWALLNPAQRKLYRDVMLETFKHLASVDNEAQLKASGSISQQDTSGEKLSLKQKIEKFTRKNIWASLLGKNWEEHSVKDKHNTKERHLSRNPRVERPCKSSKGNKRGRTFRKTRNCNRHLRKNCCTSVRRYECSQCGKLFTHSSSLIRHKRAHSGQKLYKCKECGKAFSRPSYLQTHEKTHSGEKPYACQSCGKTFLRSHSLTEHVRTHTGEKPYECGQCGKGFSCPKSFRAHVMMHAGGRPYECKHCGKAFRCQKSFRVHMIMHAGGRPYECKQCGKAYCWATSFQRHVRIHNGEKPYKCGKCGKAFGWPSSLHKHARTHAKKKPVSGGSVGKSSARPRPSTDVKSQTREKVYKCETCGKTYGWSSSLHKHERKHTGEKPVNAASVGKPSGGLCSSKNVRTQIGQKPSKCEKCGKAFSCPKAFQGHVRSHTGKKSCTSK
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 556.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.