PharMolix/UniProtQA huggingface dataset:
Protein: ADDA_STRA1
Sequence: MTFKPFLNPEDIAVIQTEEKNSDKKQKRTPEQIEAIYTFGNNVLVSASAGSGKTFVMVERILDKLLRGVPIDSLFISTFTVKAAGELKERLEKKINESLKSAESDDLKQFLTQQLVGIQTADIGTMDAFTQKIVNQYGYTLGISPIFRILQDKNEQDVIKNEVYADLFSDYMTGKNAASFIKLVKNFSGNRKDSKAFREMVYKVYAFSQSTDNPKRWMQTVFLKGAQTYTDFEAIPDQEVSSLLNVMQTTANQLRDLTDQEDYKQLTAKGVPTANYKKHLKIIENLVHWSQDFNLLYGKKGLTNLARDITNVIPSGNDVTVAGVKYPIFKQLHNRIVGLKHLEVIFKYQGESLFLLELLQSFVLDFSEQYLQEKIQENAFEFSDIAHFAIQILEENHDIRQLYQDKYHEVMVDEYQDNNHTQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNDKYKAYQDNPSQGKLIILKENFRSQSEVLDSTNSVFTHLMDEEVGDILYDESHQLKAGSPRQQERHPNNKTQVLLLDTDEDDIDDSDSQQYDISPAEAKLVAKEIIRLHKEENVPFQDITLLVSSRTRNDGILQTFDRYGIPLVTDGGEQNYLKSVEVMVMLDTLRSIDNPLNDYALVALLRSPMFGFNEDDLTRIAIQDVKMAFYHKVKLSYHKEGHHSDLITPELSSKIDHFMKTFQTWRDFAKWHSLYDLIWKIYNDRFYYDYVGALPKAEQRQANLYALALRANQFEKTGFKGLSRFIRMIDKVLENENDLADVEVALPQNAVNLMTIHKSKGLEFKYVFILNIDKKFSMVDITSPLILSRNQGIGIKYVADMRHELEEEILPAVKVSMETLPYQLNKRELRLATLSEQMRLLYVAMTRAEKKLYLVGKASQTKWADHYDLVSENNHLPLASRETFVTFQDWLLAVHETYKKQELFYDINFVSLEELTDHHIGMVNPSLPFNPDNKVENRQSEDIVRAISVLESVEQINQTYKAAIELPTVRTPSQVKKFYEPILDIEGVDVMETITKTSVDFKLPDFSTSKKQDPAALGSAVHELMQRIEMSSHVKMEDIQKALTEVNAETSVKAAIQIEKINYFFQETSLGKYIQEEVEHLHREAPFAMLKEDPESGEKFVVRGIIDGYLLLENRIILFDYKTDKFVNPLELKERYQGQMALYAEALKKSYEIEKIDKYLILLGGKQLEVVKMD
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: COX24_YEAST
Sequence: MLGRALRPGWLGITRTVVKKPSCGSYFNRTFQTAINTTMPPMQEGMLSTMMMMTATATRITGTVSEPLNGSNIVMQLDSVMRKRKKKMKKHKLRKRRKREKAERRKLSQGR
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081).  mS38 is also involved in the splicing of the COX1 mRNA (PubMed:16339141).
What are the official names of this protein?
Mitochondrial mRNA-processing protein COX24, Mitochondrial small ribosomal subunit protein mS38.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS38 family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Protein: ECHD1_DANRE
Sequence: MSMWGAVRCRLIQTRSAVRKILQQNRAFCSGSSVGIREKLLAFPGGSVELQKLQESGIAVLTVSNPPARMNAFSGCMMLELEQRVNELEIWTEGKAVIVQGAAGNFCSGSDLNAVRAIANPHDGMKMCEFMQNTLARLLRLPLISVALVEGRALGGGAELTTACDFRLMTSDAVIQFVHKHMGLVPGWGGAARLVGIIGSRNALKLLSGARKVDPDYGKQMGLVDEVLQCSSGEGKALAHAEHWIAPFIKGPAPVIQAIKKVVVSGRELSLDEALKCERSVFGTVWGGPANLEALASKPKHK
What is the function of this protein?
Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading.  Also has methylmalonyl-CoA decarboxylase activity at lower level.
What are the official names of this protein?
Ethylmalonyl-CoA decarboxylase, Enoyl-CoA hydratase domain-containing protein 1, Methylmalonyl-CoA decarboxylase, MMCD.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MASZ_NITHX
Sequence: MTRIDAHGLKIAPVLFDFIAREATPRTGIAPDAFWAGLAAIVRDLGPRNRELLAVRDTLQAQIDGWHRANKSRPFDMAAYTAFLKEIGYLLPEPATHAVETANIDDEIGKICGPQLVVPLTNARYALNAANARWGSLYDALYGTDAIAHEANEARGYDKARGDKVIAKAKAFLDSAAPLSAGSHADVAGYSVVNGHLSAKLRSGDATGLKTIAQFAGYQGAADAPSAILLVNHGLHIDIRIDRADRIGKDDPAGVADVIIEAAISTILDMEDSVAAVDADDKVLVYRNTLGLMNGTLTDTFEKGGKTVTRALNADRIYTSANGKEIALHGRSLLLMRNVGHHMVTDAVLDENGAEIPEGMLDAAVSSLLAIHDLMGISKTRNSRTGSVYIVKPKMHGPDEVALTCELFARVETMLGLPENTLKIGIMDEERRTTVNLKTCIQNASKRVCFINTGFLDRTGDEIHTSMEAGPMIRKNEMKAQPWMRAYEDWNVDIGLIDGLPGHAQIGKGMWAAPDRMADMLAQKVDHPQAGATTAWVPSPTAATLHALHYHQVDVLKQQQELKAGGQRAKLSDILTVPVSQSNWAPDDVRLEIDNNCQGILGYVVRWIDQGVGCSKVPDIHDVGLMEDRATLRISSQHLANWLHQNVVTSDQVMDSLKRMAVVVDKQNAGDPLYTPMAPTFDGVAFKAACDLVFKGREQPNGYTEYILTERRRQAKAESKGESEAAG
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPK5_LUCSU
Sequence: GGESSNEAKGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-5, FXPRL-amide, LucSu-Capa-PK.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GFA1_YEAST
Sequence: MCGIFGYCNYLVERSRGEIIDTLVDGLQRLEYRGYDSTGIAIDGDEADSTFIYKQIGKVSALKEEITKQNPNRDVTFVSHCGIAHTRWATHGRPEQVNCHPQRSDPEDQFVVVHNGIITNFRELKTLLINKGYKFESDTDTECIAKLYLHLYNTNLQNGHDLDFHELTKLVLLELEGSYGLLCKSCHYPNEVIATRKGSPLLIGVKSEKKLKVDFVDVEFPEENAGQPEIPLKSNNKSFGLGPKKAREFEAGSQNANLLPIAANEFNLRHSQSRAFLSEDGSPTPVEFFVSSDAASVVKHTKKVLFLEDDDLAHIYDGELHIHRSRREVGASMTRSIQTLEMELAQIMKGPYDHFMQKEIYEQPESTFNTMRGRIDYENNKVILGGLKAWLPVVRRARRLIMIACGTSYHSCLATRAIFEELSDIPVSVELASDFLDRKCPVFRDDVCVFVSQSGETADTMLALNYCLERGALTVGIVNSVGSSISRVTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSDDRVSKIDRRIEIIQGLKLIPGQIKQVLKLEPRIKKLCATELKDQKSLLLLGRGYQFAAALEGALKIKEISYMHSEGVLAGELKHGVLALVDENLPIIAFGTRDSLFPKVVSSIEQVTARKGHPIIICNENDEVWAQKSKSIDLQTLEVPQTVDCLQGLINIIPLQLMSYWLAVNKGIDVDFPRNLAKSVTVE
What is the function of this protein?
Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], GFAT, D-fructose-6-phosphate amidotransferase, Hexosephosphate aminotransferase.
Protein: RUVB_PSYA2
Sequence: MAKTMMQDRLINPLEGAADAPDANIRPALLAEYIGQPVVREQMEVFIQAARARDEALDHTLIFGPPGLGKTTLANIIAREMGGNLRSTSGPVLERAGDLAAMLTNLEAGDVLFIDEIHRLSPVIEEILYPAMEDFQLDIMIGEGPAARSIKLELPPFTLVAATTRAGLLTSPLRDRFGIVQRLEFYNIADLTTIVSRAARLMRVPMSEDGAVEIARRARGTPRIANRLLRRVRDYAQVRGDGSINGAIAGSALDMLAVDRRGLDHLDRRYIEILHERFDGGPAGVEAVAAAMAEDRGTLEDVIEPYLIQQGYVLRTARGRVLTQMAIDQMV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ATPF_BAUCH
Sequence: MNINATILGQAIAFTLFVLCCMKYVWPPLISIIEKRQQEIADNIKFIETTKKDLEKAKEEATKHLINIKLKAQDIIEQANKNKLQLIIEAKNEADITRKKILAQAQKQIETERKIAYEELRLQVIQLVILSTEKILENSIDKNLNSKIIDKILAKI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ARMET_DROME
Sequence: MKTWYMVVVIGFLATLAQTSLALKEEDCEVCVKTVRRFADSLDDSTKKDYKQIETAFKKFCKAQKNKEHRFCYYLGGLEESATGILNELSKPLSWSMPAEKICEKLKKKDAQICDLRYEKQIDLNSVDLKKLKVRDLKKILNDWDESCDGCLEKGDFIKRIEELKPKYSRSEL
What is the function of this protein?
Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity.  Essential for maintenance of dopaminergic neurons and dopamine levels.
What are the official names of this protein?
Mesencephalic astrocyte-derived neurotrophic factor homolog, DmMANF, MANF/CDNF-like protein.
What is the protein family that this protein belongs to?
Belongs to the ARMET family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL2_CHRSD
Sequence: MAVVKTKPTSAGRRHVVKVVSDELHKGRPYDGLLEKKSKSGGRNNNGRITTRHVGGGHRQHYRVVDFKRNKDGIAATVERLEYDPNRSANIALLKYLDGERRYIIAPRGVKVGDSLESGVNAAIKRGNALPLRNIPVGSTVHCIELKPGKGAQIARSAGASAQLVAREGNYATVRLRSGEMRKILAECRATLGEVGNSEHSLRQLGKAGAKRWRGVRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGIPTKGHKTRKNKRTDKLIVRRRKAK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RIMO_THEM4
Sequence: MNFYVEVLGCPKNEADCALLKSHLRKMGNNIVDNLSDADAVIIDTCGFILDAKKESIEEILSYVEYKKGKNLKVFVTGCLVQRFGKELKKEIPEVDGWFGVLPPKEIATHIGKRNVIPEVPEPVYNFEGRVDNGQYAYVKISDGCDRACSFCTIPLFKGSFKSRKIDDILKEIEFLIERKIKEIILVAQDTTGYGIDIYRKQMLPELLKRINDLSGDFWVRVMYMHPDHITDDIIEAFSYDKVLKYFDIPVQNGSDKILKLMNRSRKTRQLYSLFEKIRNFYSDAILRTSIIVGFPGETRKDFDETLKFIKEVKFDRLGAFIYSDEEEASSFSLSGKVPREIAEERLEELMDIQSQISFEKNEKLVGKKLKVLFDEEEDGVLIGRSYMDAPEIDANVFVRGEFKKGFFDVKITSADIYDLEGEIVEE
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYCP_HALH2
Sequence: AEPEDAIHYRQSALSVMGWQMGPMGAMAQGDIEYDADEFATRANNLAAVAHLPWEGFTEGTLQGDDHGVETDALADIGDDWEGFEERQETFKQEAATLAQMVDDGEEFSALRRQVGAVGKSCKGCHDDFRAE
What is the function of this protein?
Cytochrome c' is the most widely occurring bacterial c-type cytochrome.  Cytochromes c' are high-spin proteins and the heme has no sixth ligand.  Their exact function is not known.
What are the official names of this protein?
Cytochrome c'.
Protein: FETP_YERE8
Sequence: MSRTIFCTFLKKEAEGQDFQLYPGEIGKRIYNEISKEAWSQWVTKQTMLINEKKLSMMNVEDRKLLEQEMVNFLFEGQDVHIEGYTPPSQ
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: RUTA_ECO8A
Sequence: MQDAAPRLTFTLRDEERLMMKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGKGVNTPTAFAPTAVRMKQAAEQTGRDVGSYVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHLPALTQEVA
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
Protein: 14338_ORYSJ
Sequence: MKEREKVVRLAKLAEQAERYDDMVEFMKTLARMDVDMSAEERLLFSVGFKKTIGARRASWRILESLEQKVTAGDQPGVTINGYKKKVEDELRAVCNEVLSIIAIHCLPLANSGENVVFFYKMKGDYYRYLAEFSTGTEKKAATDQSLMAYQAWPCAQLFSLLEIMNSPERASQVAKQALDEATAEINSAGVEGYKDSMLMMQLLKENLALWTSELTGGETSKDDDVVMEG
What is the function of this protein?
Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.
What are the official names of this protein?
Putative 14-3-3-like protein GF14-H, G-box factor 14-3-3 homolog H.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: YIR4_YEAST
Sequence: MPIIGVPRCLEKPFCAPAKFPFSVKKNIRILDLDPRTEAYCLSLNSVCSKRLPCKKYFYLLNSYNIKRVLGVVYC
What are the official names of this protein?
Putative UPF0377 protein YIL174W.
What is the protein family that this protein belongs to?
Belongs to the UPF0377 family.
Protein: TSAD_FUSNN
Sequence: MIILGIESSCDETSIAVVKDGKEILSNNISSQIEIHKEYGGVVPEIASRQHIKNIATVLEESLEEAKITLDDVDYIAVTYAPGLIGALLVGVSFAKGLSYAKNIPIIPVHHIKGHMYANFLEHDVELPCISLVVSGGHTNIIYIDENHNFINIGETLDDAVGESCDKVARVLGLGYPGGPVIDKMYYKGDRDFLKITKPKVSRFDFSFSGIKTAIINFDNNMKMKNQEYKKEDLAASFLGTVVDILCDKTLNAAVEKNVKTIMLAGGVAANSLLRSQLTEKAAEKGIKVIYPSMKLCTDNAAMIAEAAYYKLKNAKNEKDCFAGLDLNGVASLMVSDEKAI
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIHD1_XENLA
Sequence: MESDKSLLSAELNSEFEQALYEQMLLKAKQEMQNRLPNTPESKQIRPQPGFCIKTQTSEKAKIFINICKTNDIPAPPDLSEAELVNILESDDPSGYRVPMSIGEPHVEVDNSGNGCTVYDIVINSTFFDKMKSNELFREFFITVAMEGLENKYEMELSRDWRMLKNRKFMGSISDQNIRTKSKPIIQELDTSSSQTLQSKPLISEIQSSPKVPEYTIAAEPSEGHPSFLVAEISLPNVTSVRSLVLDLGEDRIVLWGRPDLYHLDIFLPYNIVQEESGAQFNRDTKVLTITMPVQTI
What is the function of this protein?
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity).  Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity).  Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity).  Positively regulates the assembly and activity of the mTORC1 complex (By similarity).
What are the official names of this protein?
PIH1 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PIH1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TTL11_CAEEL
Sequence: MGCKISTEFCSDNPVGSISTSKVHPTDLSTPSYAIKPVEFYEEPLKDDQLFYKVALAKKEYREKEKDKKEQLSSNRRVSLQVEPNKLPIPLTRSSSLSSIMENRPPSGISNSSFIRSRNTASRRFTIDTSRAKSNQYVVSLCSKKIGIIEYPDGRSDKQPCDVYWHNVVLSDMNKIVTSPQSRVNKFPGMTELAKKISLTHSISSMQKLFPDEYAFYPNSWFLPAHLADFHAFYRKAQALGKTEMWFIVKPDEGAQGTGIYLINSPNQIRNVDQRQLVQEYVADPLLMNDKLKFDFRVYGVIKSINPLSIYVAREGMARFCTEKYEKPDSSNFKNLYAHLTNYSLNKANEAYVHSNTLQDQTRGSKRLLSTVFHQLESRGVKTKRLWHDIKLILVKTTLAMLPEIMLHYEHHFYDSTGPQCFQIMGFDVMIREDGTPILLEVNAAPSLTADHIVPHPGRTLLEGGQRVRSIVDEVIKIPLVRDTLLLVLGLMEEEYQNNSLKGETKSLDDMQTIKQRRKPHLSEIFPTRYGAHSGHLLFLDKAMYIYMQFVQLRSNVNITNAGLKQFVRKCNLIDIIPVVHVDAKVSEINYYFTGEKRTNGNGLPFHAFLMFLFFIAEKKFVLENDLLSKVQRLLSFCDMSLRRYGVRSARLRRAEVDSTIGNVEIYMLPSRMARNRSGTNGRKQNFTDDNNNPNSFAHLPKINERL
What is the function of this protein?
Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles (PubMed:29129530).  Regulates the localization of TRP channel pdk-2 in male CEM, HOB and RnB neurons (PubMed:29129530).  Regulates the environmental release of bioactive extracellular vesicles in cilia (PubMed:29129530).
What are the official names of this protein?
Tubulin polyglutamylase ttll-11, Tubulin--tyrosine ligase-like protein 11.
What is the protein family that this protein belongs to?
Belongs to the tubulin--tyrosine ligase family.
What are the subcellular locations of this protein?
Cell projection, axon. Perikaryon. Cell projection, dendrite. Cell projection, cilium. Extracellular vesicle.
Protein: VP2_ROTHS
Sequence: MAYRKRGARREANLNNNDRMQEKNDEKQDSNKIQLSDKVLSKKEEVVTDSHEEVKITDEVKKSTKEESKQLLEVLKTKEEHQKEIQYEILQKTIPTFEPKETILRKLEDIKPELAKKQTKLFRIFEPKQLPIYRANGERELRNRWYWKLKKDTLPDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRDAGKVVDSETASICDAIFQDEETEGAVRRFIAEMRQRVQADRNVVNYPSILHPIDYAFNEYFLQHQLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIVNTIIYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFVNNNQFRQAVIDGVLNQVLNDNIRNGHVINQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKMKAIVEDFLKRLYIFDVSRVPDDQMYRLRDRLRLLPVEIRRLDIFNLILMNMDQIERASDKIAQGVIIAYRDMHLERDEMYGYVNIARNLEGFQQINLEELMRSGDYAQITNMLLNNQPVALVGALPFITDSSVISLIAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVPTSTTKVYKQVPQQFDFRNSMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL
What is the function of this protein?
Inner capsid protein that self-assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices.  This capsid constitutes the innermost concentric layer of the viral mature particle.  It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels formed by VP2 N-termini.  VP2 is required for the replicase activity of VP1 polymerase.  Probably recruits a copy of a VP1-VP3 complex, potentially along with a segment of plus-strand RNA, as a decamer of VP2 assembles.  May activate the autoinhibited VP1/RNA complex to coordinate packaging and genome replication.
What are the official names of this protein?
Inner capsid protein VP2.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP2 family.
What are the subcellular locations of this protein?
Virion. Note=Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: HPSE_BOVIN
Sequence: MLACRKPGLRPPLLLLLPLLGPLGPCSPGTPAAAAPADDAAELEFFTERPLHLVSPAFLSFTIDANLATDPRFFTFLGSSKLRTLARGLAPAYLRFGGNKGDFLIFDPKKEPAFEERSYWLSQSNQDICKSGSIPSDVEEKLRLEWPFQEQVLLREQYQKKFTNSTYSRSSVDMLYTFASCSGLNLIFGVNALLRTTDMHWDSSNAQLLLDYCSSKNYNISWELGNEPNSFQRKAGIFINGRQLGEDFIEFRKLLGKSAFKNAKLYGPDIGQPRRNTVKMLKSFLKAGGEVIDSVTWHHYYVNGRIATKEDFLNPDILDTFISSVQKTLRIVEKIRPLKKVWLGETSSAFGGGAPFLSNTFAAGFMWLDKLGLSARMGIEVVMRQVLFGAGNYHLVDGNFEPLPDYWLSLLFKKLVGNKVLMASVKGPDRSKFRVYLHCTNTKHPRYKEGDLTLYALNLHNVTKHLELPHHLFNKQVDKYLIKPSGTDGLLSKSVQLNGQILKMVDEQTLPALTEKPLHPGSSLGMPPFSYGFFVIRNAKVAACI
What is the function of this protein?
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.  Participates in extracellular matrix (ECM) degradation and remodeling.  Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group.  Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety.  Essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes.  Facilitates cell migration associated with metastasis, wound healing and inflammation.  Enhances shedding of syndecans.  Acts as procoagulant by enhancing the generation of activated factor X/F10 in the presence of tissue factor/TF and activated factor VII/F7.  Independent of its enzymatic activity, increases cell adhesion to the extracellular matrix (ECM).  Enhances AKT1/PKB phosphorylation, possibly via interaction with a lipid raft-resident receptor.  Plays a role in the regulation of osteogenesis.  Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF.  Implicated in hair follicle inner root sheath differentiation and hair homeostasis (By similarity).
What are the official names of this protein?
Heparanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 79 family.
What are the subcellular locations of this protein?
Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity).
Protein: YBEY_BURO1
Sequence: MTLHVGAEFAPREDDPEDEPRALELDLSVQYGDEITSDVRKTLPKRKLIAEWIEPALFASAQLTVRFVGENEGRTLNAGYRHKDYPTNVLTFAYDAAPDGTVIGDLVLCCPVVEKEAHDQGKPLAAHYAHLLVHGALHAQGYDHETSDEDAAEMEALEVDILAKLGFPNPYQ
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.