PharMolix/UniProtQA huggingface dataset:
Protein: RPOB_BORA1
Sequence: MPYSYTEKKRIRKSFAKREDVQNVPFLLATQLQSYLTFLQAETATADRVNEGLQAAFTSIFPIVSHNGMARLEFVSYALGEPVFDVKECQQRGLTYASPLRAKVRLVLLDREVSKPTIKEVKEQEVYMGEIPLMTTTGSFVINGTERVIVSQLHRSPGVFFEHDRGKTHSSGKLLFSARVIPYRGSWLDFEFDPKDVLFFRVDRRRKMPVTILLKAIGMTPESILAHFFDFDNFELKSEGAMMEFVPERWKGEMARFDITDRAGKVIVEKDKRINAKHLRDLANGGIQRISVPEDFLYGRVLAKNVVDPDTGEVIALANDEITESVLDAMRAAKVLDLQTLYTNDLDRGPYISQTLRTDETVDQTAARVAIYRMMRPGEPPTEEAVEALFQRLFYSEETYDLSRVGRMKVNSRLGRGDDANGPMTLTDEDILETIKVLVELRNGRGQIDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAETENLMPHDLINSKPISAAIKEFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSMALYARLNEYGFLETPYRKIIDGRVSDQIDYLSAIEESHYVIAQANAALDAEGRFVDDLVACREAGETMLTSPVNVHYMDVAPSQIVSVAASLIPFLEHDDANRALMGANMQRQAVPCLRPEKPLVGTGIERTVAVDSGTTVQALRGGLVDHVDAERVVIRVNDEENVAGEVGVDIYNLIKYTRSNQNTNINQRPIVKRGDRVAKGDVLADGASTDLGELALGQNMLIAFMPWNGYNFEDSILISERVVADDRYTSVHIEELTVVARDTKLGPEEITRDISNLAETQLNRLDESGIVYIGAEVSADDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMTGTVIDVQVFTREGIVRDKRAQSIIDDELRRYRQDLNDQLRIVENDQFDRIEKLLVGKTVNGGPRKLAKGATVTKAYLADLDRWQWFDIRLSDEPHAVVLEQAKESLEQKRHQFDLAFEEKRKKLTQGDELPPGVLKMIKVYLAVKRRLQPGDKMAGRHGNKGVVSRITPVEDMPHMADGTTADIVLNPLGVPSRMNVGQVLEVHLGWAAKGVGQRIADMLQDERTAQVKNIRAYLEKVYNTTGTGARISELSDEEVIELANNLKRGVPFATPVFDGATEDEITMMLELAYPDDVAKRMQLTPSRAQAWLFDGRTGEKFERPVTIGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYTLQEMLTVKSDDITGRTKVYENIVKGDHVIDAGMPESFNVLVKEIRSLALDMDLERN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: STHA_SALTY
Sequence: MPHSWDYDAVVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNAHFIDEHTLALECHDGTVETLTAEKFVIACGSRPYHPNDVDFSHPRIYDSDSILSLHHEPRHVIIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALENIGLETDSRGQLKVNSMYQTALPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_GLUDA
Sequence: MKQQANLIRAGQVIEHDGRRWTVLKQQIITPGKGGAFIQVEMRDLKTGNKTNERWRTADTVERLLTEEKEYTYSYMDGDNIVLMDPETFEQTLLPLDLLGDQAPFLQDNMVLVVNLVEGDPVGVTLPAQVTLEIIEADPVVKGQTASSSYKPAKLSNGVKTMVPPFIEAGERIVVRTEDASYVERAKG
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_SHESW
Sequence: MVTIRLARGGAKKRPFYNIVVADSRNARDGRFIERVGFFNPLARGQEETLRLDLARVEHWVSNGAATTERVAKLIKDARKATA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: PTPS_CAEEL
Sequence: MFRMPIVTMERVDSFSAAHRLHSEKLSDAENKETFGKCNNSNGHGHNYVWKVKLRGEVDPTSGMVYDLAKLKKEMSLVLDTVDHRNLDKDVEFFKTTVSTSENVAIYMFEKLKSVMSNPSVLYKVTIEETPKNIFTYKGC
What is the function of this protein?
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases.  Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin (By similarity).
What are the official names of this protein?
Putative 6-pyruvoyl tetrahydrobiopterin synthase, PTP synthase, PTPS.
What is the protein family that this protein belongs to?
Belongs to the PTPS family.
Protein: DNLI1_YEAST
Sequence: MRRLLTGCLLSSARPLKSRLPLLMSSSLPSSAGKKPKQATLARFFTSMKNKPTEGTPSPKKSSKHMLEDRMDNVSGEEEYATKKLKQTAVTHTVAAPSSMGSNFSSIPSSAPSSGVADSPQQSQRLVGEVEDALSSNNNDHYSSNIPYSEVCEVFNKIEAISSRLEIIRICSDFFIKIMKQSSKNLIPTTYLFINRLGPDYEAGLELGLGENLLMKTISETCGKSMSQIKLKYKDIGDLGEIAMGARNVQPTMFKPKPLTVGEVFKNLRAIAKTQGKDSQLKKMKLIKRMLTACKGIEAKFLIRSLESKLRIGLAEKTVLISLSKALLLHDENREDSPDKDVPMDVLESAQQKIRDAFCQVPNYEIVINSCLEHGIMNLDKYCTLRPGIPLKPMLAKPTKAINEVLDRFQGETFTSEYKYDGERAQVHLLNDGTMRIYSRNGENMTERYPEINITDFIQDLDTTKNLILDCEAVAWDKDQGKILPFQVLSTRKRKDVELNDVKVKVCLFAFDILCYNDERLINKSLKERREYLTKVTKVVPGEFQYATQITTNNLDELQKFLDESVNHSCEGLMVKMLEGPESHYEPSKRSRNWLKLKKDYLEGVGDSLDLCVLGAYYGRGKRTGTYGGFLLGCYNQDTGEFETCCKIGTGFSDEMLQLLHDRLTPTIIDGPKATFVFDSSAEPDVWFEPTTLFEVLTADLSLSPIYKAGSATFDKGVSLRFPRFLRIREDKGVEDATSSDQIVELYENQSHMQN
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.  The mitochondrial form is required for mitochondrial DNA maintenance but is non-essential while the nuclear form is essential for cell viability.
What are the official names of this protein?
DNA ligase 1, DNA ligase I, Polydeoxyribonucleotide synthase [ATP] 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
What are the subcellular locations of this protein?
[Isoform Mitochondrial]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform Nuclear]: Nucleus.
Protein: SH21A_RAT
Sequence: MDAVTVYHGKISREMGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSARSPQAPTGRRDSDICLKAP
What is the function of this protein?
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7.  In SLAM signaling seems to cooperate with SH2D1B/EAT-2.  Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2.  However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1.  Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions.  Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation.  In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity).  May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (PubMed:16223723).
What are the official names of this protein?
SH2 domain-containing protein 1A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFH1_SCHPO
Sequence: MAQACKTTYSSRLKTGNTCLIQKNVAVSTRSHSSYTGRNSLRNVPAVNYAAFEQGEDFETPVETPEKEEEKFETDDRGLAVGRPTGNNIYPRFATKTRHIYVTDEQLKCAAEERDVYIPIRLDIELPNNYRLKDTFLWNMNEQVMTPDVFAQILCADLDLSTNVYGTQISSSIRAQIEEYAPVAEVPMPKGQEMLVVFNIQVQLAQLSYNDQVEWNLTSPLTPEEFSVLTCNDLGLSGESRPEIAYAIHECLLKLKKNACEGDLPDYDSDAVPGTKAGPRQDMDTLGALWQPVLETVSLEDAKKNENNRENLVKQWRREASKFGGFAADVSAERWRAAALGNLSQSETANLPSASVSDAQTLLEQERPRWRCRWCNVLGTGTFCVRRGPEGNKSLCNACGVAYAKTGQLPYWRKSLYT
What is the function of this protein?
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning.  Controls particularly membrane and organelle development genes.
What are the official names of this protein?
Chromatin structure-remodeling complex subunit sfh1, RSC complex subunit sfh1, SNF5 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the SNF5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RL30_CERS1
Sequence: MAKTIIVKQVRSAARRPAVQTAVLKGLGLNKMHRTRELEDTPSIRGMVAKIPHLVEIIEERG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: SYD_SALHS
Sequence: MRTEYCGQLRLSHVGQQVTLCGWVNRRRDLGSLIFIDMRDREGIVQVFFDPDRADALKLASELRNEFCIQVTGTVRARDAKNVNADMATGEIEVLASSLTIINRADSLPLDANHVNTEEARLKYRYLDLRRPEMAQRLKTRAKITSLVRRFMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQVREVMEALVRHLWLEVKGVDLGDFPVMTFAEAERRYGSDKPDLRNPMELVDVADLLKSVEFAVFAGPANDPKGRVAALRVPGGAQLSRKQIDDYGNFVKIYGAKGLAYIKVNERAKGLDGINSPVAKFLTADIVDAILERTGAQDGDMIFFGADNKKVVADALGALRLKLGKDLSLTDEDKWAPLWVIDFPMFEDDGEGGLTAMHHPFTAPRDMTASELKTAPEEAVANAYDMVINGYEVGGGSVRIHNGEMQQTVFGILGINEQEQREKFGFLLDALKYGTPPHAGLAFGLDRLTMLLTGTDNIRDVIAFPKTTAAACLMTEAPSFANQAALTELGIQVVKKAENN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLUQ_PSYA2
Sequence: MPITRTLPQPIGRFAPSPTGELHLGSLTTALASFCHIKSIDGKWLLRIEDTDTERCDRQFTEQILIDLEALGLNWDDDVIFQSERIDIYNDYISSVLRPLTYSCQCSRKRLERYWTQQEQQTALTDANISTDLSVSVNNDKRVDSHLLPNRQRYPRFCIKANLSPTQNKLRIQLPDYCIGFNDGIQGIQWDNPQQTLGDMVARRQDGMINYILAASLDDGLQQVTHIMRGLDILPMTTAQISIMQAARLPTISHWYHLPLICNPDGQKLSKQNLAQPIDTRHPSKLLAYALKLLGQLPVDHDTPERMLNQAISQWDNAPLQGRQSLNMATIVGEK
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity).
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: MPA92_POAPR
Sequence: MAVHQYTVALFLAVALVAGPAASYAADVGYGAPATLATPATPAAPAAGYTPAAPAGAAPKATTDEQKLIEKINAGFKAAVAAAAGVPAVDKYKTFVATFGTASNKAFAEALSTEPKGAAAASSNAVLTSKLDAAYKLAYKSAEGATPEAKYDAYVATLSEALRIIAGTLEVHAVKPAGEEVKAIPAGELQVIDKVDAAFKVAATAANAAPANDKFTVFEAAFNDAIKASTGGAYQSYKFIPALEAAVKQSYAATVATAPAVKYTVFETALKKAITAMSQAQKAAKPAAAVTATATGAVGAATGAVGAATGAATAAAGGYKTGAATPTAGGYKV
What are the official names of this protein?
Pollen allergen KBG 41, Allergen Poa p IX, Pollen allergen Poa p 9.
What is the protein family that this protein belongs to?
Belongs to the Poa p IX/Phl p VI allergen family.
Protein: IFET1_CAEEL
Sequence: MTSHLDDEGLHPMVSTLLGGGTLPTVPFKAYTRERMMELRTTKASMTRPENLSEDFNGEDGKFSPLKWLEHRWEIEGIKNRPMSKKIDSLCAGADENTGLSPQRRAFSSGCKAPTDDKGRDGEYERLGGHGKNWRNGSTGGADKFASRGNDFKPSFQKGNQLERGTRGAEWKKDTTRGAKFAPRREERLTSLSGSEKLPEWADGPTTMDDMIELRGFDEPKKVKNKKNPKEKKEKEAVKAPEPVECVGSRPSSTGLKTSEPIDDPAIAYSSSGGGALPATDQELAALLGCLDIQKTSRKIDGDDMAWAHKSEETAGGTSRLSRFFAKKNKSPELDAMLSSVGGGNDENVANPMLARLFGHSGGDNNASSSGAGDIKGGMRLEDLEKGMESKEPSKVSPLQDPSQQAQLLQHLQKFAKQQAESGQHIHHHRQPTPPNGGPQHQQHLHHPMVHPGMQIIADPSLLASFAQNPVILNAYVENQLQEAVNAAIRANNGQQLPPQLHEQLRMASMRNKAFLQSQTLTFVSLQQQHQNIQQHQQQQQHHQHKGRTPAMIPASVQRQLQKSSSNADQKKEKTSQSPPESNQETSDAHNQSDAMNQLKKLHMQQNYANMVQAMNSGVGWARGNGVVNGQQQHPQQQLPPNVQMLMAQHQQAQMQHLKMMMSRAQQQHMLMAKIAQMQQQQAQMANMQERQGPSHNQQQHQPVVPSELSQVGPIQTPLEKLLASVGVQGSQFTGSGDRIPSSVRPMSLEDLEKQLTAVPK
What is the function of this protein?
Involved in translational repression of multiple mRNAs in the distal gonad (PubMed:23264733).  Recruited to the 3' untranslated region (UTR) of zif-1 by oma-1 and is required for translational repression of zif-1 (PubMed:20826530).  May also be involved in translational repression of mei-1 through recruitment to the mei-1 3' UTR by oma-1 (PubMed:19786575).  Required for oogenesis but not spermatogenesis, for P granule formation and for the localization of car-1 and cgh-1 to P granules (PubMed:23264733).  Required for normal spindle orientation in early embryos (PubMed:19786575).
What are the official names of this protein?
Translational repressor ifet-1, Spindle orientation defective protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Note=In one-cell embryos, expressed highly and diffusely throughout the cytoplasm and is associated with P granules.
Protein: YCF3_SYNP2
Sequence: MPRTQRNDNFIDKSFTVMADIILKILPTNNRSKEAFAYYRDGMSAQADGEYSEALENYEEALRLEDDPNDRSYILYNMGLIYASNGDHHKALELYHEAIDLNPRMPQALNNIAVVYHYQGEKAKQSGNEDESEALFDKAAEYWKQAIRIAPNNYIEAQNWLKTTGRSEMDVFF
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: PURQ_ARCFU
Sequence: MDREEIKVAVLRMEGTNCEDETVKAFRSLGVEAEAVHIKQFYSDMIRFEEQRSVFDYQCLVFPGGFSAGDYIRAGAIFSARVKSVLRKDIEEFIKMGYPILGICNGFQVLVELGALPGFDEDKPLAEKPEMALAMNDSSRFECRPTLLKKESEKCIFVKNLKKDVVMFPVAHAEGKVVFPSGKEDEYLERLTSNDQIVFRYVDEKGDYAGYPWNPNGSFYNIAGICNATHTVFGLMPHPERAFFGYQVGRREGYGDGYCIFRSVVDYLEKL
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGA11_ORYSJ
Sequence: MSAAAVLAVVAAAVAALAAAASGYELTKNGTVITYDRRSLIIDGHREIFFSGSIHYPRSPPDTWPDLISKAKEGGLNVIESYVFWNGHEPEQGVYNFEGRYDLIKFFKLIQEKEMYAIVRIGPFVQAEWNHGGLPYWLREIPDIIFRTNNEPFKKYMKQFVTLIVNKLKEAKLFASQGGPIILAQIENEYQHLEVAFKEAGTKYINWAAKMAIATNTGVPWIMCKQTKAPGEVIPTCNGRHCGDTWPGPADKKKPLLWTENWTAQYRVFGDPPSQRSAEDIAFSVARFFSVGGTMANYYMYHGGTNFGRNGAAFVMPRYYDEAPLDEFGLYKEPKWGHLRDLHHALRHCKKALLWGNPSVQPLGKLYEARVFEMKEKNVCVAFLSNHNTKEDGTVTFRGQKYFVARRSISILADCKTVVFSTQHVNSQHNQRTFHFADQTVQDNVWEMYSEEKIPRYSKTSIRTQRPLEQYNQTKDKTDYLWYTTSFRLETDDLPYRKEVKPVLEVSSHGHAIVAFVNDAFVGCGHGTKINKAFTMEKAMDLKVGVNHVAILSSTLGLMDSGSYLEHRMAGVYTVTIRGLNTGTLDLTTNGWGHVVGLDGERRRVHSEQGMGAVAWKPGKDNQPLTWYRRRFDPPSGTDPVVIDLTPMGKGFLFVNGEGLGRYWVSYHHALGKPSQYLYHVPRSLLRPKGNTLMFFEEEGGKPDAIMILTVKRDNICTFMTEKNPAHVRWSWESKDSQPKAVAGAGAGAGGLKPTAVLSCPTKKTIQSVVFASYGNPLGICGNYTVGSCHAPRTKEVVEKACIGRKTCSLVVSSEVYGGDVHCPGTTGTLAVQAKCSKRPPRSAATAQ
What are the official names of this protein?
Beta-galactosidase 11, Lactase 115.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: GBB_PINFU
Sequence: MSSELEALRQETEQLKNQIREARKAAADTTLNQAAVNVEQVGRIQMRTRRTLRGHLAKIYAMHWASDSRNLVSASQDGKLIVWDGYTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIVTSSGDMSCALWDIETGQQTTAFTGHTGDVMSLSLSPDMRTFVSGACDASAKLWDIRDGMCKQTFSGHESDINAITYFPNGYAFATGSDDATCRLFDIRADQEIGMYSHDNIICGITSVAFSKSGRLLLGGYDDFNCNVWDVLRQERAGVLAGHDNRVSCLGVTEDGMAVATGSWDSFLRIWN
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta, pfGbeta1, G protein subunit beta-1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_IDILO
Sequence: MKYQGSPGFSHGQADKIGVLVTNLGTPEAPTKKALKPYLKEFLSDPRVVEVPRLLWFLILNGVILRFRPKRSAEAYKTVWTDRGSPLLFHTQDQASAIEAKLKQTWGDNIVVDFAMRYGNPALSEVVEKMMQKGVRKLLVLPLYPQYSASTTASTFDALAKDFTKRRWLPELRFITHYHDFSPFIEAAAQRIEKHWDAHGRADKLLFSYHGIPLRYLKNGDPYHCECYKTSRLLAERLGLGKDEYLTTFQSRFGREEWLQPYTDMTMKALPGKGVKSVQVFCPGFSSDCLETVEEIGEENREYFMESGGERYEYISALNAESGHIDALSQLIENNLQGWSVEDVTEQRQQRADQVKKQSLPYDD
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPAST_BOVIN
Sequence: MNSPGGRGKKKGSGGPSSPVPPRPPPPCQARSRPAPKPAPPPQSPHKRNLYYFSYPLFLGFALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPASASPPAPVPGGEAERVRAFHKQAFEYISVALRIDEDEKVGQKDQAVEWYKKGIEELEKGIAVVVTGQGEQCERARRLQAKMMTNLVMAKDRLQLLEKLQPSLQFSKSQTDVYNDSTNLTCRNGHLQSESGAVPKRKDPLTHASNSLPRSKTVMKTGPTGLSGHHRAPSCSGLSMVSGVRQGPGSAAATHKSTPKTNRTNKPSTPTTAARKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFTKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTNGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV
What is the function of this protein?
ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated.  Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold.  Severing activity is not dependent on tubulin acetylation or detyrosination.  Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.  It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia.  SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex.  Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex.  Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase.  Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling.  Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing.  Probably plays a role in axon growth and the formation of axonal branches.
What are the official names of this protein?
Spastin.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Spastin subfamily.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Endoplasmic reticulum. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Cell projection, axon. Note=Forms an intramembrane hairpin-like structure in the membrane. Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B. Enriched in the distal axons and branches of postmitotic neurons. Localizes to endoplasmic reticulum tubular network. Mainly nuclear in interphase cells and becomes associated with the centrosomes, spindle microtubules, midzone and finally the midbody during cell division (By similarity).
Protein: RL27_NEIMB
Sequence: MASKKAGGSTRNGRDSEAKRLGVKAYGNELIPAGSIIVRQRGTKFHAGDNVGMGKDHTLFAKVDGYVEFKTKGALNRKTVSIRPYTGSEE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: IXTPA_STRP3
Sequence: MSEKIYEYKDENNWFIGKMTGHNLISGWGVKHTTIKKIDDLLDGIAATLDWENPKGYDVSVVRYQSPLSLITFIIDMINQETQREIKVTPHAGTILLIENAKLLAVYLPEGGVSTATFFATSEQGFGDIILIATRNEGKTKEFRNLFGQLGYRVENLNDYPELPEVAETGTTFEENARLKAETISRLTGKMVLADDSGLKVDALGGLPGVWSARFSGPDATDAKNNTKLLHELAMVFDQKKRSAQFHTTLVVAAPNKDSLVMEAEWPGYIATQPKGENGFGYDPVFIVGETGRHAAELEADQKNQLSHRGQAVRKLMEVFPAWQAKQS
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: SUMO7_ARATH
Sequence: MSAADKKPLIPPSHITIKIKSQDDICVYFRIKRDVELRTMMQAYSDKVGQQMSAFRFHCDGIRIKPNQTPNELDLEDGDEIDAFVDQIAGFSHRH
What is the function of this protein?
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer.  Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (By similarity).
What are the official names of this protein?
Putative small ubiquitin-related modifier 7, AtSUMO7.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RIMO_FRAAA
Sequence: MSTHVPRRVALVTLGCSRNEVDSEELAGRLAAQGWELVADAADADAVLVNTCGFVDAAKKDSIDALLAADDLRAGDGEPAGAGPRAVVAVGCLAERYGNELAASLPEADAVLGFDAYPSIGEHLDAVLGGATVPAHTPRDRRTLLPITPVERGASANVAVHVPGHARGVAGGSAAGSPGRRRLTAGPVAALKISSGCDRRCAFCAIPSFRGSHVSRPADDVLAEAEWLAGEGARELVLVSENSTSYGKDLGDLRALEKLLPQLAAVPGIVRVRTVYLQPAELRPSLLEVLLTTPGLAPYLDLSFQHASPAVLRRMRRFGGSEHFLDLLDRGRGLLPGLGARSNVIVGFPGETEADVDILAEFLEAAELDAVGVFGYSDEEGTEAVSLPGKIAEEEIERRRVQITDLVEQLTATRAQERIGSRVQVLVEEITDGIAAGCAGHQQPDADGSCLVRLPGPAGAAAGPPAGGPSGTGQPGLPGQPGQPGVEVGDLIEARVVATEGVDLVAEFTAVLDRARPSAGRGEAAPSATGARATVLVGRPRADGT
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.