PharMolix/UniProtQA huggingface dataset:
Protein: RDRP_I57A0
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVIESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTVSLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWDGLQSSDDFALILNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: IF2_CHESB
Sequence: MTDTKTGDDKTLSVNTKKTLTIKRPGVEQGTVRQNFSHGRTKAVVVETKKRKFSRSDERVEPVAPMRPKAPAPSPAPAPAPQPRETPRPQPQQSRSGVVLNELSADEIEARRRALQDAKLRETEERKRAEEEARRRAEEDERRQREREESARRQAEEEARLKAEAEARKRAEEEAKRRTPVVETPAVVAEAVEEEEERGGRGGLAKRGAVKPEAPVRPVKPRGEEERRRGKLTLNSALSDEESTRSRSLSSMRRRQEKFKRAMQQEQREKVSREVVIPETITIQELAQRMAERAVDVVKYFMKQGQIMKPGDVIDADTAELVAVEFGHTAKRVAESDVEEGLFNIEDRPEDLKPRPPVVTIMGHVDHGKTSLLDAIRKANVVAGEAGGITQHIGAYQVEQDGNTITFIDTPGHAAFTAMRARGAQATDIAILVVAADDSVMPQTVESINHAKAAGVPIIVAINKIDKPDANPQKVRTELLQHEVFVESMGGDVLDVEVSAIKGTNLDKLLEAILLQAEILELKANPDRTAEGVVVEAKLDRGRGSVATVLVQAGTLKPGDVIVAGSEWGRVRALVNERGEAVKVAPPSTPVEVLGLQGPPQAGDRFAVVDTEARAREISEYRQRKAREKAVARQAGQRGSLEQMMSQLQSSGMKEFPLIIKGDVQGSIEAIVNALEKLGTEEVRARIVHSGAGAITESDISLAETSDAAIIGFNVRANKQARDAAEQAGIEIRYYNIIYDLVDDIKAAMSGLLSPERRETFLGNAEILEVFNITKVGKVAGCRVTEGKVERGAGVRLIRDNVVIHEGKLKTLKRFKDEVSEVPAGQECGMAFENYEDIRVGDVIEAFRVEHVTRTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2501_XYLFT
Sequence: MFCHLLGDNYEAVIYSTENRFTPSVYSCGNSGCLVLQFADIQSSP
What are the official names of this protein?
Uncharacterized protein PDa0001.
Protein: ACKA_CLOB1
Sequence: MKILVVNCGSSSLKYQLIDMTSEEALAKGLVERIGIEGSILTQKVNGEKYIIEEPMKDHKKAIELVLKALVDKEHGVISDMSEIAAVGHRVVHGGEKYASSVLINDEVMKALEDCVKLAPLHNPPNIIGINACRELMPKTPMVAVFDTAFHQTLPDYAYMYPLPYELYEQNGIRKYGFHGTSHRYVSSVASEMMGKDLKDLKVITCHLGNGASLCAVKEGKSVETSMGFTPLAGLAMGTRCGDIDPAILLFMERELKMSPDEVDTVINKKSGVLGISGVSSDFRDIEGAAEEGNKRAKLALDVYHYTVRQTIGAYTAVLNGVDAIVFTAGLGENSAASREEILNGLEYLGIKIDAEKNKQRGKQIEISTEDSKVKVFVIPTDEELMIARDTKEITVK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_SYNPW
Sequence: MTDSNPQTNPNDIPSAADVPAAAEGQQEQRRGGGGRGDRGDRRGGRRGDRRNQERDSEWQERVVQIRRVSKTVKGGKKMSFRAIVVVGNERGQVGVGVGKAGDVIGAVRKGVADGKKHLVKVPLTRHNSIPTLSNGRDGAASVLIRPAAPGTGVIAGGSIRTVLELAGIKNVLAKRLGSKTPLNNARAAMVALDSLRTHKETAKERGISLEQIYS
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: NOE2_HUMAN
Sequence: MWPLTVPPPLLLLLCSGLAGQTLFQNPEEGWQLYTSAQAPDGKCICTAVIPAQSTCSRDGRSRELRQLMEKVQNVSQSMEVLELRTYRDLQYVRGMETLMRSLDARLRAADGSLSAKSFQELKDRMTELLPLSSVLEQYKADTRTIVRLREEVRNLSGSLAAIQEEMGAYGYEDLQQRVMALEARLHACAQKLGCGKLTGVSNPITVRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFIKGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYNNTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVMRSWDTGYPKRSAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRERALYTWNNGHQVLYNVTLFHVISTSGDP
What is the function of this protein?
Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation.  TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399).  Plays a role in AMPAR complex organization (By similarity).  Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF.  SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli.  SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).
What are the official names of this protein?
Noelin-2, Olfactomedin-2.
What are the subcellular locations of this protein?
Secreted. Synapse. Membrane. Nucleus. Cytoplasm. Note=Nuclear localization is induced by TGF-beta.
Protein: HECW1_HUMAN
Sequence: MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1.  Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS).  Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
What are the official names of this protein?
E3 ubiquitin-protein ligase HECW1, HECT, C2 and WW domain-containing protein 1, HECT-type E3 ubiquitin transferase HECW1, NEDD4-like E3 ubiquitin-protein ligase 1, hNEDL1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLC1_MOUSE
Sequence: MYDNMSTMVYIKEEKLENVTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQNVRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDSDSSKEPLDDLFPNDEDEPGQGIQHSDSSAAAARQGYEIPARLRTLHNLVIQYASQGRYEVAVPSCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDRTPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEAEFGSVDDENKPIWMHAEEREECKGKQKDGSAFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPESMEKRRSRESLNMDVVKYESGPDGGEEA
What is the function of this protein?
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.  The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
What are the official names of this protein?
Kinesin light chain 1, KLC 1.
What is the protein family that this protein belongs to?
Belongs to the kinesin light chain family.
What are the subcellular locations of this protein?
Cell projection, growth cone. Cytoplasmic vesicle. Cytoplasm, cytoskeleton.
Protein: KGUA_XANAC
Sequence: MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSADEFQGMIEAGDFFEYALVHGDWKGTARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFILPPSRQALDERMRKRGQDSEVVMAQRLAAAREEMLHFEEFDYVIINETFDTAVSEMCAIFTASRLRRQAQQQRHAGLIRALLD
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZUPT_ECOLU
Sequence: MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFGLDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSVMGFSLVLLQTAGIG
What is the function of this protein?
Mediates zinc uptake.  May also transport other divalent cations.
What are the official names of this protein?
Zinc transporter ZupT.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL17_BACAA
Sequence: MAYRKLGRTSAQRKAMLRDLATDLIINERIQTTETRAKELRSVVEKMITLGKRGDLHARRQAAAFIRNEVANAETGQDALQKLFADVAPRYAERQGGYTRIAKIGPRRGDAAPMVIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: WCAJ_ECOLI
Sequence: MTNLKKRERAKTNASLISMVQRFSDITIMFAGLWLVCEVSGLSFLYMHLLVALITLVVFQMLGGITDFYRSWRGVRAATEFALLLQNWTLSVIFSAGLVAFNNDFDTQLKIWLAWYALTSIGLVVCRSCIRIGAGWLRNHGYNKRMVAVAGDLAAGQMLMESFRNQPWLGFEVVGVYHDPKPGGVSNDWAGNLQQLVEDAKAGKIHNVYIAMQMCDGARVKKLVHQLADTTCSVLLIPDVFTFNILHSRLEEMNGVPVVPLYDTPLSGVNRLLKRAEDIVLATLILLLISPVLCCIALAVKLSSPGPVIFRQTRYGMDGKPIKVWKFRSMKVMENDKVVTQATQNDPRVTKVGNFLRRTSLDELPQFINVLTGGMSIVGPRPHAVAHNEQYRQLIEGYMLRHKVKPGITGWAQINGWRGETDTLEKMEKRVEFDLEYIREWSVWFDIKIVFLTVFKGFVNKAAY
What is the function of this protein?
Is the initiating enzyme for colanic acid (CA) synthesis.  Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl-pyrophosphoryl-undecaprenol (Glc-PP-C55).  Also possesses a weak galactose-1-P transferase activity.
What are the official names of this protein?
UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase, UDP-Glc:Und-P Glc-1-P transferase, Colanic acid biosynthesis UDP-glucose lipid carrier transferase, Glucosyl-P-P-undecaprenol synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial sugar transferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS19_SYNWW
Sequence: MGRSLKKGPYCEDKLLKKIELMNQSGQKKVIKTWSRRSTIMPEMIGHTLAVHDGRKHIPVYVTEDMVGMKLGEFAPTRTYRGHAGKSEKSSRAR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: FRDD_ACTP2
Sequence: MNKQDPKRSNEPPVWLMFSAGGTISAICFPVLLLILGVLLPLGLVPVENIVAFAHTWFGKLVILAVTIFPMWAGMHRVHHGLHDLKIHFPAGGWVFYGLSALYSVIVFFAVIAL
What is the function of this protein?
Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TFC3_YEAST
Sequence: MVLTIYPDELVQIVSDKIASNKGKITLNQLWDISGKYFDLSDKKVKQFVLSCVILKKDIEVYCDGAITTKNVTDIIGDANHSYSVGITEDSLWTLLTGYTKKESTIGNSAFELLLEVAKSGEKGINTMDLAQVTGQDPRSVTGRIKKINHLLTSSQLIYKGHVVKQLKLKKFSHDGVDSNPYINIRDHLATIVEVVKRSKNGIRQIIDLKRELKFDKEKRLSKAFIAAIAWLDEKEYLKKVLVVSPKNPAIKIRCVKYVKDIPDSKGSPSFEYDSNSADEDSVSDSKAAFEDEDLVEGLDNFNATDLLQNQGLVMEEKEDAVKNEVLLNRFYPLQNQTYDIADKSGLKGISTMDVVNRITGKEFQRAFTKSSEYYLESVDKQKENTGGYRLFRIYDFEGKKKFFRLFTAQNFQKLTNAEDEISVPKGFDELGKSRTDLKTLNEDNFVALNNTVRFTTDSDGQDIFFWHGELKIPPNSKKTPNKNKRKRQVKNSTNASVAGNISNPKRIKLEQHVSTAQEPKSAEDSPSSNGGTVVKGKVVNFGGFSARSLRSLQRQRAILKVMNTIGGVAYLREQFYESVSKYMGSTTTLDKKTVRGDVDLMVESEKLGARTEPVSGRKIIFLPTVGEDAIQRYILKEKDSKKATFTDVIHDTEIYFFDQTEKNRFHRGKKSVERIRKFQNRQKNAKIKASDDAISKKSTSVNVSDGKIKRRDKKVSAGRTTVVVENTKEDKTVYHAGTKDGVQALIRAVVVTKSIKNEIMWDKITKLFPNNSLDNLKKKWTARRVRMGHSGWRAYVDKWKKMLVLAIKSEKISLRDVEELDLIKLLDIWTSFDEKEIKRPLFLYKNYEENRKKFTLVRDDTLTHSGNDLAMSSMIQREISSLKKTYTRKISASTKDLSKSQSDDYIRTVIRSILIESPSTTRNEIEALKNVGNESIDNVIMDMAKEKQIYLHGSKLECTDTLPDILENRGNYKDFGVAFQYRCKVNELLEAGNAIVINQEPSDISSWVLIDLISGELLNMDVIPMVRNVRPLTYTSRRFEIRTLTPPLIIYANSQTKLNTARKSAVKVPLGKPFSRLWVNGSGSIRPNIWKQVVTMVVNEIIFHPGITLSRLQSRCREVLSLHEISEICKWLLERQVLITTDFDGYWVNHNWYSIYEST
What is the function of this protein?
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements.  Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function.  Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes.  TFC3 is essential for cell viability.  Cooperates with TFC6 in DNA binding.
What are the official names of this protein?
Transcription factor tau 138 kDa subunit, TFIIIC 138 kDa subunit, Transcription factor C subunit 3.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: LYSX_MYCVP
Sequence: MTPTSLARARPTSSHRWVPAAAGWIVGVIATLSLLASVSPLVRSLIRVPREWVDDYIFNFPDTSFAWAFVLALLAAALAARKRIAWWILVGYMIAAAGWNIAGLAEGRERWFAEVGEVIGLAFHLAAIAFLLLARKEFWARVRRGALLKAAATLVASMAVGTLIGWGLLELFPGSLARSDRFLYALNRVSAFAGADAASFSGHPHVFVNALLGLFGAVALMVTAIVLFQSQRADNALTGEDESAIRGLLELYGKNDSLGYFATRRDKAVVFAPSGRAAITYRVEVGVCLASGDPVGDPRSWPQAIDAWLKLCQAYGWAPGVMGASAAGAQAFREAGLNALQLGDEAILHPEDFRLSGPDMRAVRQAVTRARRAGATVRIRRHRELPADEMAAVIERADAWRDTDDERGFSMALGRLGDPADGDCLLVEAVQADQVVAMLSLVPWGGNGVSLDLMRRSPQSPNGTIELMVSELCMQSEDIGITRISLNFAMFRSAFEQGAQLGAGPVARLWRWLLVFFSRWWQLETLYRSNMKYQPEWVPRYACYDDARLVPRVGVASVIAEGFLVLPFSRRHEQPHTGHHIAAPGTLVATGLLHSDGTAPDGMGLQADLADDDQPRLPEQVRVRMAKLKALQAQGVDAYPVANPPSHTVAQALAAEDGADVAVAGRVLRSRDYGGVLFAQLRDWSGETQLVLDNSLLADGSTADFTRTIDLGDLIEVTGTMGRSRSGKWSLLVSGWRLIGKCLRPLPDKWKGLTDQEARVRARYVDLAVNTDARELIRARSAVLHAIRETLVAKDFLEVETPILQQIHGGANARPFLTHINAYDLDLYLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYHVWIDGCRELIQNAAQAANGAQVFMRPRADGVLEPVDISGPWTVKTVHGAVSEALGEQIGPDTDLATLRLLCDRAGIPYLTHWDAGAVVLELYEHLVEDQTREPTFYKDFPTSVSPLTRPHRSIPGVAERWDLVAWGVELGTAYSELTDPVEQRRRLQEQSLLAAGGDPEAMELDEDFLQAMEYAMPPTGGLGMGVDRVVMLITGRSIRETLPFPLAKPR
What is the function of this protein?
Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge.  LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M. tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins).  In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides (By similarity).
What are the official names of this protein?
Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YTFE_SALG2
Sequence: MAYRDQPLGELALSIPRASALFRQYDMDYCCGGKQTLARAAARHDVDIDIIEAQLAQLAEQPIEKDWRAVPLADIIDHIVVRYHDRHREQLPELILQATKVERVHADKPNVPRGLTKYLTALHEELSSHMMKEEQILFPMIKQGMGRQATGPISVMESEHDEAGELVDVIKHVTQNVTPPPEACTTWKAMYNGINEMIDDLMEHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_ENTFA
Sequence: MTTLQEKIIQELGVLPTIDPKEEVRKSIDFLKAYLTKHPFLKTFVLGISGGQDSTLAGRLAQLAMTEMREETGDMSYQFIAIRLPYGEQADEADAQAALAFIQPDVSLRVDIKPAVDAMVGSLENAGVQISDFNKGNMKARQRMITQYAVAGENAGAVIGTDHAAENVTAFFTKYGDGGADILPLFRLNKRQGKALLKELGAPEALYLKIPTADLEDDKPLVADEVALGVTYDAIDDYLEGKKVSETDQQTIENWYKKGQHKRHLPITIFDDFWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: NADE_BURMS
Sequence: MSRPDQAARRRAIAAELHVSPTFDARDEAERRIGFVADYLRTAGLRACVLGISGGIDSSTAGRLAQLAVERLRASGYDARFVAMRLPYGAQHDEADARRALAFVRADETLTVDVKPAADAMLAALAAGGLAYLDHAQQDFVLGNIKARERMIAQYAVAGARNGVVIGTDHAAESVMGFFTKFGDGGADVLPLAGLTKRRVRALARMLGADEPLVLKTPTADLETLRPQRPDEHAYGITYEQIDDFLEGKPMDDAVAETVLRFYDATHHKRALPYTMFDWPGHPA
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: ZNT4_MOUSE
Sequence: MAGPGAWKRLKSLLRKDDTPLFLNDTSAFDFSDEVSDEGLSRFNKLRVVVADDDSEAPERPVNGAHPALQADDDSLLDQDLPLTNSQLSLKMDPCDNCSKRRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYMANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMGFLLYEAVQRTIHMNYEINGDVMLITAAVGVAVNVIMGFLLNQSGHHHSHAHSHSLPSNSPSMVSSGHNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKSTAIVHMQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTIQLQSYRQEVIRTCANCHSSST
What is the function of this protein?
Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (PubMed:9354792).  Controls zinc deposition in milk (PubMed:9354792).
What are the official names of this protein?
Probable proton-coupled zinc antiporter SLC30A4, Lethal milk protein, Solute carrier family 30 member 4, Zinc transporter 4, ZnT-4.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Note=Enriched in vesicles within the basal region of epithelial cells.
Protein: RBGA_MYCPN
Sequence: MDTFTSAVKINWFPGHMKKTHDQLKKLASSLDGVIEVVDARAPTLTQNPEITAYFTNKPKLTLALKADLAQTVANSNILWGTLKQGLQLKRLVIKKLQTLFQAKKNQLKAKGLLVHQFRLAVIGMPNVGKSSLINLLLNKNHLQVANRAGVTKSMSWNQISSEFYLSDTPGVFFKRIDEMAVGYKLVLTNVIKREVVPLEDVGAFAFCYLSKHYPQLLPYEGTDFTEFLHKFAISRKLLQKSNQLNINLACELFVSELINGKYGKLSFELD
What is the function of this protein?
Required for a late step of 50S ribosomal subunit assembly.  Has GTPase activity.  Binds to the 23S rRNA (By similarity).
What are the official names of this protein?
Probable ribosome biogenesis GTPase A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFA1E_ARATH
Sequence: MEVSLTAGAIGKIMNGEVTTEADMIPVLQVTDLKQIMAQQDPTRERFRMVLSDGTYLHQGMLGTDLNNLVKEGTLQPGSIVRLTRFVGDVIKGRRIVIVPQLEVLKQISDIIGHPVPGGKHNDQRGADSGIKFNTTEQQGSGIRQVNNIEPGRSNAAISPQVGGTGSSVPASTTPSTRAYSNPSSGNGVTRQDYARDPPTSYPHQPQPPPPMYANRGPVARNEAPPKIIPVNALSPYSGRWTIKARVTNKAALKQYSNPRGEGKVFNFDLLDADGGEIRVTCFNAVADQFYDQIVVGNLYLISRGSLRPAQKNFNHLRNDYEIMLDNASTIKQCYEEDAAIPRHQFHFRTIGDIESMENNCIVDVIGIVSSISPTVTITRKNGTATPKRSLQLKDMSGRSVEVTMWGDFCNAEGQRLQSLCDSGVFPVLAVKAGRISEFNGKTVSTIGSSQLFIDPDFVEAEKLKNWFEREGKSVPCISLSREFSGSGKVDVRKTISQIKDEKLGTSEKPDWITVSATILYLKFDNFCYTACPIMNGDRPCSKKVTDNGDGTWRCEKCDKSVDECDYRYILQLQIQDHTDLTCVTAFQEAGEEIMGISAKDLYYVKNEHKDEEKFEDIIRKVAFTKYNFKLKVKEETFSDEQRVKATVVKVDKLNYSADTRTMLGAMDKLRTRDANSLPINPEGSDYNADVVNTGIGSSGTRDPSSVQRRDFGLHAHQSGQSGNHYSGGGATTSCNVCGNSGHVSAKCPGATKPQEQGQYMGGSYRGTTGSYGGGLPRQHVGSY
What is the function of this protein?
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication.  The activity of RPA is mediated by single-stranded DNA binding and protein interactions.  Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity).
What are the official names of this protein?
Replication protein A 70 kDa DNA-binding subunit E, AtRPA70E, AtRPA1-1, Replication factor A protein 1E, Replication protein A 1E, AtRPA1E.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 1 family.
What are the subcellular locations of this protein?
Nucleus.