PharMolix/UniProtQA huggingface dataset:
Protein: PROB_SINMW
Sequence: MTKARKALDKYRRVVIKIGSALLVDRKTGLKKSWLDAMCADIAALRAKGVEVLVVSSGAIALGRTVLDLSAGALKLEESQAAAAVGQIVLARAWSESLSTHAIVAGQILLTLGDTEERRRYLNARATIGQLLRLGSVPIINENDTVATTEIRYGDNDRLAARVATMVGADLLVLLSDIDGLYTAPPHLDPNARLLETVAEITPDIEAMAGGAASELSRGGMRTKIDAGKIATTAGCAMIIASGKPEHPLAAVEAGGRSSWFAPAGSPVTARKTWIAGQLLPAGSLSIDAGAETALRSGKSLLPAGVRQVTGSFGRGDTIAIIGASGREIARGLAGYDAEEARQIAGKKSAEIAVILGYAGRAAMVHRDDLVMTAPSGGRLAEESDEGKGKLHA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSGA_GEOKA
Sequence: MAEGQIIKALSGFYYVLSEGRVFQCRGRGVFRKKKVTPLVGDRVVFQATSETEGYILEIGERQNELVRPPIANVEQAILVFSAVSPDFSAKLLDRFLVLVESKRITPIIVISKIDLLDGESKEEIARYVHDYRRIGYDVIETSAVTKGGLDELALRLRGRVSVVAGQSGVGKSSLLNALRPDLRLKTGDISTHLGRGKHTTRHVELLEVAGGLVADTPGFSALEFNQIELDELPHYFPEFRTYGEGCKFRGCLHIAEPKCAVREAVEAGEIPSYRYDHYVSFVAEMKERKPRY
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_CHRVO
Sequence: MSTNVTMRQMLEAGVHFGHQTRFWNPKMAKYIFGSRNKIHIINLEKTLPLFVEAQEYVRRLAANKGTVMFVGTKRQAREIVREEAARCGMPFVDHRWLGGMLTNYKTVKQSIKRLEEKRAILEGAGETGYNKKELLDLQREVEKLERSLGGIKDMKGLPDAIFVIDTGYQKGTIVEAKKLGIPVIGVVDTNNSPDGIDYVVPGNDDSSRAIRLYARGIADAVLEGRAHSLQEIVAAAETAQAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: FADB_SHEPA
Sequence: MIYQSPTIEVELLEDNIAHLCFKAQGSVNKFDRETIDSLNAALDSIKQDSSIKALMLSSAKDAFVVGADITEFLGLFAEEDTVLQSWLEQANVVFNKLEDLPFPTISAINGFALGAGCETILATDFRIADTTARIGLPETKLGIIPGFGGTVRLPRVIGADNALEWITSGKDQRPEAALKVGAIDAVVAPEQLKPAALKMLKDALIEKLDWQTRRAKKQAPLTLPKLEAMMSFATAKGMVFKVAGKHYPAPMAVISVIEQAAQLDRAGALQVEHQAFIKLAKTEVAQALIGIFLNDQLVKGKAKKAGKLAKKVNSAAVLGAGIMGGGIAYQSASKGTPIVMKDIAQPALDLGLGEAAKLLTAQVKRGRSTPAKMAAVLNNITPALDYAPVKDADVVVEAVVEHPKVKSMVLAEVEQHVSEDAIITSNTSTISINLLAKSLKKPERFCGMHFFNPVHKMPLVEVIRGENSSDETVASVVAYASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSGLLADGADFAAIDKVMEKQFGWPMGPAYLLDVVGLDTGHHAQAVMAEGFPDRMGKTGKDAIDVMFEAERFGQKNSKGFYQYSVDRRGKPKKDLDPTSYELLQAEFGEQKAFESDEIIARTMIPMIIETVRCLEEGIIASPAEADMGLVYGLGFPPFRGGVFRYLDTMGVANFVALADKYAHLGGLYQVTDTMRELAANNGSYYQQA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: Y5916_DICDI
Sequence: MSNKEEEKEKERFSEEYIENAKTQINKLFFDRIGGLIGFSDQDNNQDINHKNTLNLNYQEREEEDDDEEETTQTVNVYSTIGINNNNNINKTFKINDNETIIINNNNNDNDNNNKEKEDNDEKEYQRIKSEYIKISKRYFELKEKRIIKKRNKE
What are the official names of this protein?
Putative uncharacterized protein DDB_G0279989.
Protein: Y1552_DROME
Sequence: MYQLEKIWVLLCLALVGVLGFGQFHMKHYQLQRNYNTQEDSGENDNSVLRTFRRCMWEQSKFLPRRLVLLSLCSNLFCENNHIMPRSRSIFVVEKMSRPNDCLDILPEQCEQGDEEELMYKPFPDCCPVYCNLKRRMQRLRTMHFRHRLLRNKQDGSAGSAGGGSAGGDGPNNSLLSEFVYNNY
What are the official names of this protein?
Uncharacterized protein CG1552.
Protein: FPG_MANSM
Sequence: MPELPEVETAKNGITPYLEGYLIEKIIVRQPKLRWEVSPQLAQISQQKITALSRRAKYLIIHTEQGYIIGHLGMSGSVRIVSARDPVDKHDHLDIVMNNGKIMRYNDPRRFGTWLWSANLDEFHLFLKLGPEPLSDEFNAEYLFKKSRKKQTPVKNFLMDNSVVVGVGNIYANETLFMCGLHPEKITAKLTKAQCALLVEKIKQELKRAIEQGGTTLKDFLQPDGRPGYFAQELQIYGKKGAPCPNCGTKIESLVVAQRNSYFCPKCQKK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: MVK_PYRFU
Sequence: MKVIASAPAKVILFGEHSVVYGKPAIAAAIDLRTFVEAELIREKKIRIEAHDIKVPGLTVSFSENEIYFETDYGKAAEVLSYVREAINLVLEEADKKNVGIKVSITSQIPVGAGLGSSAAVAVATIGAVSKLLGLELSKEEIAKMGHKTELLVQGASSGIDPTVSAIGGFIFYEKGKFEHLPFMELPIVVGYTGSSGPTKELVAMVRKRYEEMPELIVPILEAMGKVVEKAKDVILSNVDKEEKFERLGVLMNINHGLLDALGVSTKKLSELVYAARVAGALGAKITGAGGGGCMYALAPNKQREVATAIRIAGGTPMITEISREGLKIEEVIK
What is the function of this protein?
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP).  Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
What are the official names of this protein?
Mevalonate kinase, MK, MVK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA1_GEOSL
Sequence: MTRLNILMAASECVPFAKEGGLADVVGVLPKYLAHMGHDVRVVMPLYSRIDPERFGLERLPGVLVVPMGIMGNQYCGVWEGRLPGSAVPVYFLEHEGYYGREGLYEEDNVGYMDNDNRFIFLSRAAMELPKLIGFAPDVFHAHDWHTAAVPVFLNTLYRDDPLVGGAASVLTVHNMQHQGNFYPGAMEVLGIGWEHFTFLGLEKDNQTNLLKGGLYHATVLNTVSEGYAREMQTPEYGWGLDGVVRARSADLVGILNGVDYEEWNPETDPHIVANYSRSDLSGKKLCKRDVQRFFGLPERDDVPLFGLVGRLVKQKGIDILAEAIHRILALDVQVVMLGAGEPWSHFYFGDVRNEYPEKFGLYIGYNNGLSHRIEAGSDFFVMPSAFEPCGLNQMYSLRYGTLPIVRATGGLDDSVENFDEQNLTGNGFKFWSHDADALFDTVGWTVHTWYRRKDAMAALIGNAMAKRFTWEDSAARYEELYCRALRKRLGVGVFVRRFGG
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase 1, Starch [bacterial glycogen] synthase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: RUVC_RHIEC
Sequence: MQNTIRIIGIDPGLRRTGWGIIDTLGNSLKFVASGTVTSDGEMDLASRLCQLHDGLADIVHAHKPDEAAVEQTFVNKDAVATLKLGQARGIAMLVPARAGLPVSEYAPNAVKKAVIGVGHGEKQQIHMMLKILMPKAEFKGDDAADALAIAICHAHNRGGHRMRQALAG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: KDSB_THEYD
Sequence: MVTICVIPARYGSTRFPGKPLAFLKNKPIIQHVYERAKSSKMIDEVFVATDDSRILHTVESFGGKAIMTSSKHPSGTDRIAEAVDKLLQEGYNLQESSIVINLQGDEPLIKKEMIDQLIDLMKNENDSIGTLAKRIEKEDDFFNPNIVKVVFDKNGYALYFSRSPIPFDREKFIKGFSKNNFMYKHIGIYGYNVRILKNFVGLPMSRLEEIESLEQLRALENGIKIKVGLTEYDSFGIDTPEDLEVAEKCLNTYS
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAAA_NATPD
Sequence: MTRIVVVDNHGQFTHLEHRALRDLGVDTELIDNDTPPEEIDADGIVLSGGPDMDRIGHSPAYLDLDIPVLGICLGMQLMAAELGGRVGAGDYGGYADVTVSIEDESDPLIGSLAPETRVWASHADEVKELPDGFERTATSEVCNIEAMSDTDRNRYGVQWHPEVAHTEAGEEVFENFRDICAGD
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit A, Glutamine amidotransferase.
Protein: BR2B_RANTE
Sequence: MFTMKKSLLLFFFLGTISLSLCQEERNADEDDGEMTEEEKRGILDTLKHLAKTAGKGALQSLLNHASCKLSGQC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Brevinin-2Tb.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: CALM1_RAT
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
What is the function of this protein?
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding.  Calcium-binding is required for the activation of calmodulin.  Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.  Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.  Is a regulator of voltage-dependent L-type calcium channels.  Mediates calcium-dependent inactivation of CACNA1C.  Positively regulates calcium-activated potassium channel activity of KCNN2.  Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding.  Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2.
What are the official names of this protein?
Calmodulin-1.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium, flagellum. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
Protein: RR8_BUXMI
Sequence: MGRDTIANIITSIRNADMDKKGTVRIASTNITENIVKILLREGFIENVRKHRESNKYFLVSTLRHRRSRKGPYRTILKRISRPGLRIYSNYQRIPRILGGMGIVILSTSRGIMTDREARLEGIGGEILCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PLS4_PITNO
Sequence: FLSLIPHAINAVSAIAKHF
What is the function of this protein?
Has antiparasitic activity against trypomastigote form of T. cruzi (IC(50)=0. 34 uM) and against promastigote form of L. infantum (IC(50)=10. 06 uM) (PubMed:24113627).  Probably acts by permeabilizing cell membranes (PubMed:24113627).  In vitro, shows slight cytotoxicity against macrophages (IC(50)=34. 42 uM) (PubMed:24113627).  Has antibacterial activity (By similarity).
What are the official names of this protein?
Phylloseptin-N4, PLS-N4, Phylloseptin-7.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EPPI_MOUSE
Sequence: MKLSGFVSILVLFGLLARVQGPSLADLLFPRRCPRFREECEHQERDLCTRDRDCPKKEKCCVFNCGKKCLNPQQDICSLPKDSGYCMAYFRRWWFNKENSTCQVFIYGGCQGNNNNFQSQSICQNACEKKSSLT
What is the function of this protein?
Serine protease inhibitor that plays an essential role in male reproduction and fertility.  Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity).
What are the official names of this protein?
Eppin, Epididymal protease inhibitor, Serine protease inhibitor-like with Kunitz and WAP domains 1.
What are the subcellular locations of this protein?
Secreted. Cell surface. Note=Present on the surface of spermatozoa both before and after capacitation.
Protein: RL18_PSEPF
Sequence: MTDKKVTRLRRARKARLKMHELEVVRLCVFRSSQHIYAQVISADGNKVLASASTLDKELRDGATGNIDAATKVGQLVATRAKAAGVSQVAFDRSGFKYHGRVKALADAAREAGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: HISZ_BACC7
Sequence: MTKWKRANPNGTRDYLFEECTLIEEVEQKLRRTFLERGYEEIRTPTIEFYDVFAFQSRPIDEEKMYKFFDEKGRIIVLRPDMTIPLARVIGTQRCDTPLKVTYSGNVFRANESLTGKYNEIVQSGIEIIGIDNVRAEIECVISVIQSLQKLKVQSFTIEIGQVQLYKCIVKKLSIHEEEEKVLRTYIESKNYAALSNFIRDKKLDRCDETVKLLEKLPRLFGNLEVIEEAEKLASSNEMKMAITRVKEIYEAIDKLGYGSYISIDLGMIQHLDYYTGVIFKGYIYEIGEEIVSGGRYDELIGNFGEMLPAVGLAVQVNQIVKALQEQQKPYERKRIDIMIHYELNRLAEAERLRNLLQKDGKKVALSLFSNLNDTFQFARKNQIVTVVEAKNESLVEYVWKEKWVVQKEGETSCVTFKLR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GFA_PENRW
Sequence: MAPSLHPLIDNGITPGSGSFAGGKLRCHCASDRVEVTLNSNVAHNHACGCSKCWKPSGSLFSIVGVVPRDAVSVTANASKLSVVDKEATIQRYGCKDCGVHLFGRIEKDHPFRGLDFVHVELSDEKGWQEPQFAGFVSSIIEQGSHPKEMDEVRAKFKALGLQTYDVLSPALMDLISTFTAQASGIRFANL
What is the function of this protein?
Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.
What are the official names of this protein?
Putative glutathione-dependent formaldehyde-activating enzyme, S-(hydroxymethyl)glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the Gfa family.
Protein: Y1033_BRUAB
Sequence: MTISLKTAPLLEVSNLSVDFRTDGGWINAVDDVNFTLAPRETLGLVGESGSGKSVTALSLLRLHDQRNSRLGGSVRYKGEDLFTLATSRLRQIRGHEIAMVFQDPIHTLNPVLTIGRQIEEGLRLHHGLQGREARKRAIELLDRVRIPDAARRIDEYPHRMSGGQRQRVMIAIAIAGDPKILIADEPTTALDVTVQAQIMELLRNLRDELSMSVILISHDLGLVSEFADRAMVMYAGQPVETGPIDKIFDEPLHPYTEGLLSAIPDLDDDLDRLPTIPGSIPEPSRRPPGCRFAPRCTFAQASCVKPQPIMSLTGGRASRCPPRLPTEECVL
What is the function of this protein?
Probably part of an ABC transporter complex that could be involved in peptide import.  Probably responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative peptide import ATP-binding protein BruAb2_1033.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TEPA_HALH5
Sequence: MDYGRQDEQPEQPQQPEQPQQEPSQEGKPSGIIEKIQQLGQTNVPEMEQSNIHCITVVGQIEGHMQLPPQNKTTKYEHIIPQLVAAEQNKKIEGLLIILNTVGGDVEAGLAIAEMVATMSKPTVTLVLGGGHSIGVPIAVAANYSFIAETATMTIHPVRLTGLVIGVPQTFEYLDKMQERVVSFVTKHSHISEEKFKELMFSKGNLTRDIGTNVIGTDAVTYGLIDEVGGIGKAMQKLTELIEKQQPPHPEGEMMQ
What is the function of this protein?
This activity is required for efficient translocation of pre-proteins across the membrane.
What are the official names of this protein?
Translocation-enhancing protein TepA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family. TepA subfamily.
Protein: Y1669_MYCLB
Sequence: MMPSTPRTSIPSITLNDENTMPLLGLGVAELSEDETERAVLAALEIGCRLIDTAAAYGNEAAVSRAIAASGIPRAQLFVTTKLATPDQGFTKSQDACNASLDRLGMDYVDLYLIHWPAPPVGQYVDAWGGMIQSRGEGHARSIGVCNFTEEHLSAIIDLTFVTPAVNQIELHPLLNQDEMRKSNAQHNVITQSYTPLVLGRLMDNSTLTAIAAEYGKTPAQVLLRWNLQLGNAVVFRSAKAEHIASNFDVFDFELAVNHMDAMNELHDGTRLRPDPETYAGS
What are the official names of this protein?
Uncharacterized oxidoreductase MLBr01669.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: C79D2_MANES
Sequence: MAMNVSTTATTTASFASTSSMNNTAKILLITLFISIVSTVIKLQKRASYKKASKNFPLPPGPTPWPLIGNIPEMIRYRPTFRWIHQLMKDMNTDICLIRFGKTNVVPISCPVIAREILKKHDAVFSNRPKILCAKTMSGGYLTTIVVPYNDQWKKMRKVLTSEIISPARHKWLHDKRAEEADQLVFYINNQYKSNKNVNVRIAARHYGGNVIRKMMFSKRYFGKGMPDGGPGPEEIMHVDAIFTALKYLYGFCISDYLPFLEGLDLDGQEKIVLNANKTIRDLQNPLIEERIQQWRSGERKEMEDLLDVFITLQDSDGKPLLNPDEIKNQIAEIMIATIDNPANAVEWAMGELINQPELLAKATEELDRVVGKDRLVQESDIPNLNYVKACAREAFRLHPVAYFNVPHVAMEDAVIGDYFIPKGSWAILSRYGLGRNPKTWPDPLKYDPERHLNEGEVVLTEHDLRFVTFSTGRRGCVAALLGTTMITMMLARMLQCFTWTPPPNVTRIDLSENIDELTPATPITGFAKPRLAPHLYPTSP
What is the function of this protein?
Involved in the biosynthesis of the cyanogenic glucosides linamarin and lotaustralin.  Can use L-valine or L-isoleucine as substrate.
What are the official names of this protein?
Valine N-monooxygenase 2, Cytochrome P450 79D2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein.
Protein: ATG4_ASPNC
Sequence: MNTVDIGRCSKRIVQYLWDPEPRNDEDPNSSIWCLGIEYHPDKDANTRETPDKNNTRENVMGTTNYRKPSEHAWPESFLLDFESRIWMTYRSNFPPIPRVEGDDKSASMTLGVRLRSQLVDTQGFTSDTGWGCMIRSGQSLLANALSMLVLGRDWRRGARFEEESQLLSLFADTPTAPFSVHRFVKHGAESCGKYPGEWFGPSATAKCIEALSSQCGNPTLKVYVSNDTSEVYQDKFMDIARNTSGAFQPTLILLGTRLGIDNITPVYWDGLKAALQFPQSVGIAGGRPSASHYFVGAQGSHLFYLDPHYTRPALPDRQEGELYSKEEVDTYHTRRLRRIHVRDMDPSMLIGFLIRNQEDWADWLKRIEAVKGRPIIHVLKQMNPDHDQEAGALDQVEALDDIE
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Probable cysteine protease atg4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: CDH_MYCBO
Sequence: MPKSRRAVSLSVLIGAVIAALAGALIAVTVPARPNRPEADREALWKIVHDRCEFGYRRTGAYAPCTFVDEQSGTALYKADFDPYQFLLIPLARITGIEDPALRESAGRNYLYDAWAARFLVTARLNNSLPESDVVLTINPKNARTQDQLHIHISCSSPTTSAALRNVDTSEYVGWKQLPIDLGGRRFQGLAVDTKAFESRNLFRDIYLKVTADGKKMENASIAVANVAQDQFLLLLAEGTEDQPVAAETLQDHDCSITKS
What are the official names of this protein?
Probable CDP-diacylglycerol pyrophosphatase, CDP-diacylglycerol phosphatidylhydrolase, CDP-diglyceride hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Cdh family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: AAEB_SALNS
Sequence: MGIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIAALIIIISMIRAPLLMILVCCVWAGFCTWISSLVRIENSYAWGLSGYTALIIVITIQTEPLLTPQFALERCSEIVIGIGCAILADLLFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKALNTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGERETPVTLYSWVGAATRYLLLKRGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGNGAMVMIAVVTSLAMRLPNPRMVCIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVISAGSDDKRRRYFGQLLDELDIYQEKLRIWEAPPQVTEPVKRLTGMLHKYQNALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.