PharMolix/UniProtQA huggingface dataset:
Protein: RIMM_ACTP2
Sequence: MSEQKIEVVGKLGSTYGIRGWLRLYSSTEETESIFDYQPWFLKIKGQWQPIELESWRYHNNDLIVKLKGSDDRESAQLLTNAEIGVDLSVFPELEEGDYYWHDLIGCQVINLEDYSMGVVTELMETGSNDVLVVRANSKDAFGKQERLIPFLYEQVVKRVDLATKTITVDWDAGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP4D1_DROSI
Sequence: MFLVIGAILAGALFVGLLLYQLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVDVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIREGSSQESSKDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNSFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKDPLMFKVRERVY
What is the function of this protein?
Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Cytochrome P450 4d1, CYPIVD1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: PRI2_SCHPO
Sequence: MFRTTKSRVVEKNQNFSSASFESLSYPTRLNFYKKPPVSEISIEEFETWAIDRLVVLGEIESAMLRNKTKNELNGIIKKILDKRLPMSSNMARTVKGNSLDEERRKDHYSHFILRLAFSRSDELRIRFLRAESTLFRFRFVNEETRERQAFIDSLDFQWESVSQEEKDVFYEKLQASSQRNIENESFFKVPFFKVPDLVERRAVFVHKGYAYVPFSEQVSLVVEEFEENLKKALESTAKSLPRLDEDDRLLPILNHLSKGFVAPESSIVAPKSGAITAGQVDSFVSHFPLCAKHLHEVLKRDKHLRHFGRLQYGLFLKDIGLSVDEALVFWRKSFTNVTEDKFNKEYRYNIRHTYGLEGNRKNYKGYNCQQILTGPQLGPGDAHGCPYRTYSVNNLVSALASMGIAPDSAGCREVVEAVKARHYHIACTRVFELTHPNVGSLEESIHHPLQYFQLSLES
What is the function of this protein?
Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (By similarity).  During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit pol1, an accessory subunit spb70/pol12 and two primase subunits, the catalytic subunit spp1/pri1 and the regulatory subunit spp2/pri2) is recruited to DNA at the replicative forks (By similarity).  The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity).
What are the official names of this protein?
DNA primase large subunit, DNA primase 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase large subunit family.
Protein: MUC20_HUMAN
Sequence: MGCLWGLALPLFFFCWEVGVSGSSAGPSTRRADTAMTTDDTEVPAMTLAPGHAALETQTLSAETSSRASTPAGPIPEAETRGAKRISPARETRSFTKTSPNFMVLIATSVETSAASGSPEGAGMTTVQTITGSDPREAIFDTLCTDDSSEEAKTLTMDILTLAHTSTEAKGLSSESSASSDSPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGLHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSWSPGSDVTLLAEALVTVTNIEVINCSITEIETTTSSIPGASDTDLIPTEGVKASSTSDPPALPDSTEAKPHITEVTASAETLSTAGTTESAAPDATVGTPLPTNSATEREVTAPGATTLSGALVTVSRNPLEETSALSVETPSYVKVSGAAPVSIEAGSAVGKTTSFAGSSASSYSPSEAALKNFTPSETPTMDIATKGPFPTSRDPLPSVPPTTTNSSRGTNSTLAKITTSAKTTMKPPTATPTTARTRPTTDVSAGENGGFLLLRLSVASPEDLTDPRVAERLMQQLHRELHAHAPHFQVSLLRVRRG
What is the function of this protein?
May regulate MET signaling cascade.  Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation.  Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway.  Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
What are the official names of this protein?
Mucin-20, MUC-20.
What are the subcellular locations of this protein?
Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane.
Protein: RPOB_DELAS
Sequence: MAYSYTERKRIRKSFGSRDSVLEVPYLLQMQKDAYTAFLQSDVAPKKRTIEGLQAAFNSAFPIVSHNGFVEMKFVEYNLAKPAFDVRECQTRGLTFASAVRAKVQLIIYDRESSTSQSKVVKEVKEQEVYMGEVPLMTEKGSFIINGTERVIVSQLHRSPGVFFEHDKGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDLLFFRVDRRRKMPVSILLKAIGLTPESILANFFVNDNFRLMDSGAQMEFVSERLRGEVARFDITDKSGKVVVAKDKRVTARHTRELEQSGTKFISVPEDFLIGRVVAKNIVDPDTGEIIAKANEELTESLLKKLRSAGIQDLQCIYTNELDQGAYISQTLRTDETVDEFAARVAIYRMMRPGEPPTEDAVQALFQRLFYNPDTYDLSRVGRMKFNAKVGRDGATGPMVLSNEDILAVVKILVDLRNGKGEVDDIDHLGNRRVRCVGELAENQYRTGLARIEKAVKERLGQAEQEPLMPHDLINSKPISAALKEFFGASQLSQFMDQTNPLAEITHKRRVSALGPGGLTRERAGFEVRDVHVTHYGRVCPIETPEGPNIGLINSLALYARLNEYGFIETPYRRVADGKVTMEIDYLSAIEEGKYIIAQANAELDAEGRLIGDLVSAREKGDSTLVSAERVQYMDVSPAQIVSVAASLIPFLEHDDANRALMGANMSRQAVPVLRPEKPMVGTGIERVAAVDSGTVVTATRGGIVDYVDATRIVVRVNDAEAVAGEVGVDIYNLIKYQRSNQNTNIHQRPIVKRGDKLAKGDVVADGASTDLGEIAIGQNMLIAFMPWNGYNFEDSILINERVVAEDRYTSIHIEELVVMARDTKLGAEEITRDIPNLSEQQLNRLDESGIIYVGAEVQPGDVLVGKVTPKGETTLTPEEKLLRAIFGEKASDVKDTSLRVDQGSQGTVIDVQVFTREGIQRDKRAQQIIDDELKRYRLDLNDQLRIVEADAFDRIEKLLNGRVANGGPQKLAKGAKIDKAYLDGVEKFHWFDIRPAEDEVATQLESIKNSLEQTRHSFDLAFEEKRKKLTQGDELPAGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPVEDMPYMADGSTADIVLNPLGVPSRMNIGQVLEVHLGWAGKGLGQRIGDMLQQEARAAEIRTFMEEIYNSRGRKEDLTQLDDKEIVSMAQALTTGVPFATPVFDGASEQEIQDMLHLAYPEELAQRKGLTESRTQAYLYDGRTGDRFERPTTIGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYVLQEMLTVKSDDVVGRTKVYESIVKGEHAIEAGMPESFNVLVKEIRSLGLDIELERS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: KLD10_RAT
Sequence: MSAAQGWDRNRRRGGGAAGGASGVSGAGAAGGGRGTGQLNRFVQLSGRPHLPGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKRPSRIYGQAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQELIERLK
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.  The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) at the C-terminus, leading to their ubiquitination and degradation (By similarity).  Participates in the oxidative stress-induced cell death through MAP3K5 activation.  Inhibits PPP5C phosphatase activity on MAP3K5.  Acts as a regulator of necroptosis (By similarity).
What are the official names of this protein?
Kelch domain-containing protein 10.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: SEMG2_MACNE
Sequence: MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLSSGSSRFPHRHRSQHYSGQKDKQHTESKGSFSIQHTYHVDANDHDRTRKSQQYYLNAQHKTTKSKQHLRRRQRLLNYKQKGRGRVKPKRHFHLIVIHRKGGQVHHGTQNPSQDQGNSPSGKGIFRQYSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQLETKNSHQNKGHYQNVVDVREEHSGKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLNQDQEHGQKAHKISYQSSRTEERQLNHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKISYQSSSAEERRLNSGEKGIQKGVXKGSISIQTEEKIYGKSQNQVTIPSQDQEHGHKENKISYQSSSAEERRLNSGEKGIQKGVXKGSISIQTEEKIYGKSQNQVTIPSQDQEHGHKENKISYQSSSTEQRQLNYGRKSIQKDVIQSSLSFQTEKLVEGKSQIQTPNPNQGQWSGQNAKGNSGKSADGEQDLLSHEQEGRYQQEFSGAHNTVNIEHEVAYDDLLTQQYNEDRNPIST
What is the function of this protein?
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
What are the official names of this protein?
Semenogelin-2, Semenogelin II, SGII.
What is the protein family that this protein belongs to?
Belongs to the semenogelin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRHO_SHEB5
Sequence: MTKVVVCALYKFVSLPHFESIRAPLLAMMEQAEIKGTLLLASEGINGTVAGTQEAIEALLVWLNSQNGLDNIVHKLSFDDEMPFYRTKVKLKNEIVTMGVEGIDPLKVVGTYVKPQDWNALISDPDVILVDTRNDYEVQIGTFKNAVNPVTETFREFPEYVKQNLDPAKHKKVAMFCTGGIRCEKSTAYLKEQGFDEVYHLEGGILKYLEEVKAEESLWEGECFVFDNRVAVNHDLKKGQYDQCNACRMPITEVEKQSPAYVQGVSCPHCIDKISDEQRKRFVERERQVNLAKARNEAHIGSDVNQVIEARREKKEAQRRLAAEKNNAKKSQVL
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: RL14_SALCH
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVILNNNSEQPIGTRIFGPVTRELRNEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RK22_NUPAD
Sequence: MIKKTQGTEIRALARHIGMSAQKARRVIDQIRGCSYEQTLMILELMPYRACYPIFKLVYSAAANASHNRGLKEADLFISKAEVNEGVIVKRLKPQARGRSYPIKRPTCHITIVLSERPNFTLKNI
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYT_BURCJ
Sequence: MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSTVIDRDASLAIVTDKDADGLDIIRHSTAHLLAYAVKELYPDAQVTIGPVIDNGFYYDFSYNRPFTPEDLEKIEKRMQELAKKDEPVTRRVVSRDEAAGYFRSIGEKYKAEIIESIPQSDEIKLYSHGGFTDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTKKEDQDQYLHMLEEAEKRDHRKLGKQLDLFHMQEESPGMVFWHPKGWALWQQVEQYMRRRVNEAGYLEIKTPMIMDRSLWEASGHWQNYRENMFTTESEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSCHRNEASGALHGLMRVRGFVQDDAHIFCTEDQFISESIAFNTLAMSVYKDFGFDHIDIKLSLRPDQRAGTDETWDRAEQGLRDALTACGLTWEELPGEGAFYGPKIEYHIKDALGRSWQCGTLQLDMVLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPYQAIVLNIAESQAEYAQSLAQSLQKQGVRVAADLRNEKISYKIREHTLEKVPYLLVVGDKERDAQTVAVRARGGVDLGVMPVEAFVERLQEDLRSFK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBOA7_HUMAN
Sequence: MSPEEWTYLVVLLISIPIGFLFKKAGPGLKRWGAAAVGLGLTLFTCGPHTLHSLVTILGTWALIQAQPCSCHALALAWTFSYLLFFRALSLLGLPTPTPFTNAVQLLLTLKLVSLASEVQDLHLAQRKEMASGFSKGPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQPFPGAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLEAVREDAFYARPLPARLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGAYPVAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRDGMRYWNMTVQWWLAQYIYKSAPARSYVLRSAWTMLLSAYWHGLHPGYYLSFLTIPLCLAAEGRLESALRGRLSPGGQKAWDWVHWFLKMRAYDYMCMGFVLLSLADTLRYWASIYFCIHFLALAALGLGLALGGGSPSRRKAASQPTSLAPEKLREE
What is the function of this protein?
Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128, PubMed:18094042).  Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:18772128, PubMed:18094042).  In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259).
What are the official names of this protein?
Lysophospholipid acyltransferase 7, LPLAT 7, 1-acylglycerophosphatidylinositol O-acyltransferase, Bladder and breast carcinoma-overexpressed gene 1 protein, Leukocyte receptor cluster member 4, Lysophosphatidylinositol acyltransferase, LPIAT, Lyso-PI acyltransferase, Membrane-bound O-acyltransferase domain-containing protein 7, O-acyltransferase domain-containing protein 7, h-mboa-7.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria.
Protein: DDL_TRIL1
Sequence: MTRDELKQKRIGVLMGGLSAERDVSLKSGMAVHQALLAMGYDSTALDVRHNVALILREEKIDLAFIALHGRYGEDGCIQGLLELMQIPYTGSGVLASALAMHKLYSKQAFAAAGLTITPYATVRQGDRCNAEQLPFGLPVVVKPVQEGSSVGVTIVKKPEDLQAALDEAFRYDTLVLVEKYIKGQEVQVGILANQPIGAIEIVPKNEFYDFEAKYSDGMAEHIFPARLAEPLYQKVQQQGLQAHQALGCDGYCRVDFLVTENGDCYLLEVNTLPGMTALSLLPEIAQKGAGLSFEALVEQIACSAALKTGQAG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPAT_CITBB
Sequence: MAKINDNYLKLKAGYLFPEIGRRVRAFAAANPEAKVIRLGIGDVTQPLTPTILKAFHDAVDDLASENSFMGYGPEQGYDFLIDAIIEKSYKPLGVDLKTTEMFISDGSKCDCANILDIFALDNTVAIGDPVYPVYNDTNVMIGRTGDADDKGYYKGLVYMPCTEENGFFPAYPKEKVDMIYLCFPNNPTGAVATKAQLKGWVDYALANDSIILFDAAYEAFITDPSIPHSIYEVEGAKKCAIEFRSFSKTAGFTGVRCGLVVVPDELEGTTSNGEKYSFNKLWLRRQTTKFNGASYPVQKAAAAVYTEQGWKETQANIDYYMENARIIREGLSAAGVTVYGGVNAPYIWLKTPAGLTSWDFFDKLLNDCHVVGTPGSGFGPSGEGYFRLSAFGNRDNVVEAVERIKKNLKK
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
What are the official names of this protein?
LL-diaminopimelate aminotransferase, DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: EFTU_DESDA
Sequence: MGKEKFERKKPHVNIGTIGHIDHGKTTLTAAITKVANLKSGGKFISYDEIDKAPEEKERGITIATSHVEYETDKRHYAHVDCPGHADYIKNMITGAAQMDGGILVVAATDGPMPQTREHILLARQVGVPQLVVFLNKCDLVDDEELLELVELEVRELLSSYDFPGDDVPVIRGSALKALESDDPNSAEAKCILDLLDACDSFIPEPVRDIDKPFLMPIEDVFSISGRGTVVTGRVERGVIKVGEEVEIVGIKPTVKTTCTGVEMFRKLLDQGEAGDNIGALLRGTKRDDVERGQVLAAPKSITPHKKFKAEVYVLSKEEGGRHTPFFTGYRPQFYFRTTDITGVISLPEGVEMVMPGDNSQFIVELIAPIAMEAGLRFAIREGGRTVGSGVVTEINE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_STRPD
Sequence: MAHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPPRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGAYARKKKAFITNPKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_CASCR
Sequence: MLLENIGYDNKSSLLIVKRLITTMYQQNYLIISANDSKQNPFFGYNKNLHSKILSEGFAIIVEIPFYLRLISSLEGAEIVRFYNLRSIHSIFPFLEEKFPHLNYSADILIPYPAHLEILVQTLRYRVKDASYLHLLRFFLHEYSNCNSLIITNKSISIFSKSNPRFFLFLYNSYICEYESIFLFLRNQSSHLRLTSSGVLFERLCLYRKIEHFAEVFANDFPVIPCFLKDPFMHYVRYQGKSILASKDTPLLMNKWKSYLVNLWQCHFDVWSHAASIRINQLSKHSLDFLSYFSSVRRNPAVVRNQMLENSFPLNNAPNKLDTIVPIIPLIGSLAKAKFCNAVGHPISKLTRADLSDFEIINRFLHICRNLSHYYSGSSKKKNMYRIKYILRLSCVKTLARKHKSTARAFLKRVDSEFFQEFFTEEGGFISLIFPRASFALRRLYSGRVWYLDIIFINGLSNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BRX1_BOVIN
Sequence: MAATKRKRRGGLAVQAKKLKRDAKDGKLPAKANDVSEEAAEEEKDRIPGPVCKGKWKNKERILIFSSRGINFRTRHLMQDLRMLMPHSKADTKMDRKDKLFVINEVCEMKNCNKCIYFEAKKKQDLYMWLSNSPHGPSAKFLVQNIHTLAELKMTGNCLKGSRPLLSFDPAFDELPHYALLKELLIQIFSTPRYHPKSQPFVDHVFTFTILDNRIWFRNFQIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPHYQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKTILPHDPTADVFVTPAEEKPVEIQWVKPEPKVDLKARKKRIYKRQRKMKQKMSSGNAK
What is the function of this protein?
Required for biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein BRX1 homolog, Brix domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the BRX1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RNPH_METEP
Sequence: MRPSKRAADAMRDVTLERAVARYAEGSCLVTFGNTRVLCTASLEERGPPWLRGSGKGWVTAEYAMLPRATHERTRREVNSGKPSGRTQEIQRLIGRSLRAVTNLPALGERQITVDCDVIQADGGTRTASITGAWVALHDCFAWMRARSIISVDPLKDHVAAVSCGIYKGQPVLDLDYAEDSAAETDANFVVTGKGGIVEVQGTAEMEPFTDEQFLELLRLAKGGVAGLVELQRKAIA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: PTCD2_HUMAN
Sequence: MVRDSMAAAFRPSNRVLLQALQILVYPGVGGSGSVSCRCPLGAKRYLLTDNVVKLKEFQQKKVAVACNLSGTKETYFRNLKKKLTQNKLILKGELITLLHLCESRDHVELAKNVIYRYHAENKNFTLGEYKFGPLFVRLCYELDLEESAVELMKDQHLRGFFSDSTSFNILMDMLFIKGKYKSALQVLIEMKNQDVKFTKDTYVLAFAICYKLNSPESFKICTTLREEALLKGEILSRRASCFAVALALNQNEMAKAVSIFSQIMNPESIACINLNIIIHIQSNMLENLIKTLKNAAEGNLSKFVKRHVFSEEVLAKVREKVKDVPALVAKFDEIYGTLHITGQVTTDSLDAVLCHTPRDRKSHTLLLNKRMVSRRTFQPLSQSLLAE
What is the function of this protein?
Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function.
What are the official names of this protein?
Pentatricopeptide repeat-containing protein 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PTCD2 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GPDA_SHEFN
Sequence: MNNAAEITVLGAGSYGTALAISLASNGHKTLLWGHDPKSMQVLAESRSNERFLPGIQFPDCLSIEADLGKALAASKNILVVVPSHVFGDVLKQAKPLLRDDARIVWATKGLEPETGRLLQDVAREQLGEHYPLAVLSGPTFAKELAAGLPTAISVAGTCPQFTHDLVELLHSPKRLRVYANDDFIGIQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLVELSRLGEAIGADASTFIGMAGLGDLVLTCTDNQSRNRRFGLALGQGKDVITAQEEIGQVVEGYRNTKEVFTLAKRLGVEMPITEQIYQVLYQGKAPVEAAKELLSRDKKSETLKK
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBX1_HUMAN
Sequence: MMFPGLLAPPAGYPSLLRPTPTLTLPQSLQSAFSGHSSFLVEDLIRISRPPAYLPRSVPTASMSPPRQGAPTALTDTGASDLGSPGPGSRRGGSPPTAFSPASETTFLKFGVNAILSSGPRTETSPALLQSVPPKTFAFPYFEGSFQPFIRSSYFPASSSVVPIPGTFSWPLAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNRRMKWRNSKERELLSSGGCREQTLPTKLNPHPDLSDVGQKGPGNEEEEEGPGSPSHRLAYHASSDPQHLRDPRLPGPLPPSPAHSSSPGKPSDFSDSEEEEEGEEQEEITVS
What is the function of this protein?
Could have a role in patterning the central nervous system during embryogenesis.  Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons.  Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).
What are the official names of this protein?
Homeobox protein DBX1, Developing brain homeobox protein 1.
What is the protein family that this protein belongs to?
Belongs to the H2.0 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ILVD_LISMO
Sequence: MRSDKIKKGVEQAPARSLLHATGQIKSPGDMDKPFIAICNSYIDIVPGHVHLRELADVAKEAIREAGGIPFEFNTIGVDDGIAMGHIGMRYSLPSREVIADAAETVINAHWFDGVFYIPNCDKITPGMLLASVRTNVPAIFCSGGPMKAGLSAHGKALTLSSVFEAVGAFKDGSMSQEDFLDMEANACPTCGSCAGMFTANSMNCLMEILGMAVPGNGTTLAVSDARRDLIRESAFHLMDLVKKDIRPRDIITKDAIDDAFALDMAMGGSTNTVLHTLALANEAGIEDYDLERINDIAKRVPYLSKIAPSSSYSMHDVHEAGGVSAIVKELVDLGGAIHPDRITVTGKTIRENVADAKINNTDVIHPKENPYSPVGGLSMLFGNIAPKGAAIKVGGVDPSVQVFKGEAICFSSHDEAVEAIDNHTVREGHVVVIRYEGPKGGPGMPEMLAPTSSIVGRGLGKDVALITDGRFSGATRGIAVGHISPEAAAGGPIALVHDGDIITIDLPNRTLNVDVPDEVLEERRKELPKFKAKVKTGYLARYTALVTSAHTGGILQIPEDLID
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.