PharMolix/UniProtQA huggingface dataset:
Protein: IR25A_DROME
Sequence: MILMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSNAADHPGKLVDGVILGHSGEKFEKSKAALRPRFNQYPATFKPRF
What is the function of this protein?
Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection (PubMed:21220098, PubMed:27161501, PubMed:27656904).  Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b (PubMed:21220098).  Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27126188, PubMed:27161501, PubMed:27656904).  Required in chordonotal organ neurons for behavioral synchronization to low-amplitude temperature cycles and mediates circadian clock resetting by temperature (PubMed:26580016).  Together with Ir40a and Ir93a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behavior (PubMed:27161501, PubMed:27656904).
What are the official names of this protein?
Ionotropic receptor 25a.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Perikaryon. Cell projection, cilium. Note=Low levels detected in the axon segment adjacent to the perikaryon in some sensory neurons of the antenna but not detected along axons as they enter the brain or at synapses within antennal lobe glomeruli. In coeloconic neurons, prominently expressed both in the perikaryon and in the distal tip of the dendrite which corresponds to the ciliated outer dendritic segment innervating the sensory hair. Relatively low levels detected in inner dendrites (PubMed:19135896). Detected in dendritic bulbs of the dorsal organ cool cells (PubMed:27126188).
Protein: RL2_METI4
Sequence: MGIKDFRPLTPVQRFTSLDDFSDITKTEPEWDLTEPYKKKGGRNNYGRITARHRGGGHKQRYRIIDFKRDKTGIFATVEAIEYDPLRTARIALLRYDDQEKRYIIAPQELKVGSRVVSGPDAPPEVGNSLPLKNIPSGLPIYNIELVPGKGGQLVRSAGSSARMMGLDKEYAIVKLPSGEIRKVCAECYATVGQVSNPDHFNKSLGKAGRTRWLGWRPRVRGVAMNPVDHPNGGGQGKSKGGGGWQQLESPWGKPAKGKKTRHKRKNSTKFIIERRPKKKKKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ARCA_STRGC
Sequence: MSTHPIHVFSEIGKLKKVMLHRPGKELENLMPDYLERLLFDDIPFLEDAQKEHDNFAQALRNEGIEVLYLEKLAAESLTSPEIRDQFIEEYLDEANIRGRQTKVAIRELLQGIKDNQELVEKTMAGVQKAELPEIPEAAKGLTDLVESDYPFAIDPMPNLYFTRDPFATIGNAVSLNHMYADTRNRETLYGKYIFKYHPVYGGNVELVYNREEDTRIEGGDELVLSKDVLAVGISQRTDAASIEKLLVNIFKKNVGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIQGNLRVFSVTYENEQLKIVEEKGDLAELLAENLGVEKVTLIPCGDGNAVAAAREQWNDGSNTLTIAPGVVVVYDRNTVTNKKLEEYGLRLIKIRGSELVRGRGGPRCMSMPFEREEI
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_SULAC
Sequence: MSKKYLVAYMTLGYPNVNDFYKFIDNIEDFGVDILEIGIPPKYAKYDGPVIRKTYKIVSNNIKNYYEILYEVKQRIKIPVVILTYLEEYVDKLGDFLLKLKESRVDGVLFPDLLIDYVDEYEKYVNLIKNEGIKTVLFTAPLMPDDLIIKASKLTDLFLYYGVRPTTGVVIPISIDSLINRIRTMVQSKLVVGFGLNSIEDIKKAMSVGADGIAVGTSLIEEVDKNGVNGALELIKKLRGVLDEY
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: MX2_SHEEP
Sequence: MSMSYRALKFRRHAPTSTQHHPKEDMNFHQQPPGLPGPALGQTMSPPPWQMGESNPDFLPNNFNQLNLDPQQPEADGGQQRSKGSENNLYRKYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIITRCPLVLKLTKRECEWTGKITYRNVTQQLHNPSEVEREIRRAQNIIAGNGVGISHELINLEVTSPEVPDLTLIDLPGITRVAVENQPQDIGLQIKALIKTYIQRQETINLVVVPCNVDIATTEALSMAQEVDPDGDRTIGILTKPDLVDKGTEKGVLKVMQNLTYHLKKGYMIVKCRGQQDITNKLSLAEATRKEVMFFQTHPYFRVLLDEGKATVPLLAERLTTELIWHINKSLPLLENQIKEKHQRATEELQQYGDDIPSNEGDKMFFLIEKIKLFNEDIEKLIEGEEIVIETESRLCNRIREEFTRWVLILTTNIEKVKSILNEEVSKYETKYRGKELLGFVNYKTFETVVKHYLGQLIDPALKMLQKAMEIIWQTFKDTAKKHFAEFCNLHQTVQNKIEDIKTKQMAEAANLIQLQFRMEKLVFCQDQIYGVVLNKVREEIFNSVGKASENPQSKHPFLNNQSSVSSIVEIGVHLNAYFTETSKRLANQIPFIIQYFMLQENGDKVQKAMMQLLQETQHYSWLLQEQSDTATKRKFLKEKIFRLTQAQQALYEFPHFKSI
What is the function of this protein?
Interferon-induced dynamin-like GTPase with antiviral activity.
What are the official names of this protein?
Interferon-induced GTP-binding protein Mx2, Myxovirus resistance protein 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HISZ_BRUA2
Sequence: MTMVGSRTSPIFNALRVELNAREAELVEIPLIQPADPFLDMAGEDLRRRIFLTENENGDSLCLRPEFTIPVCRNHIALNAATPKRYAYLGEVFRQRRDGAAEFLQAGIEDLGAADEAASDARSLADALSCVKAIAPDAPLEIVLGDQSVFAGMLKALGLPQGWRKKLLRSFGDAHSMDLALAELTGTQRRDPLPESLAVLVAEGDEIGLARMLEAEMLEAGISPGAGRTPVEIARRLIEKEDLAATHFPAAALDLLRQFLAIRVSLDMAAVTLRAFAADNALDLGAVLQKFEARADAIAQAGIEMKDIIYDASFGRPLDYYTGLVYEIRDASNRQDGVLAGGGRYDRLLTMLGACEAIPGVGFSIWLDRLQALAGEKQ
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_NEIG1
Sequence: MKTARRRSRELAVQAVYQSLINRTAAPEIAKNIREMSDFAKADEELFNKLFFGTQTNAADYIQKIRPLLDRDEKDLNPIERAVLLTACHELSAMPETPYPVIINEAIEVTKTFGGTDGHKFVNGILDKLAAQIRPDEPKRR
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: TYW4_NEUCR
Sequence: METTEEVVAPATTQQPATEVGSAKPTTSTYSKKQKKPKATTTTTTTDGTTPTHNEHASAKDPRKAQDDQVMGTNNSSIVSKRSVEKLYYPNEPHFFRFFVKKFQRRAPLINRGYHFRLHVIDVLVRNFLQEQRTGDAKGKRKVVVNLGCGSDVLPWQCLARYPDACRSGEKDGAKFVDVDFPDLIERKKRTVLETPELLGPLTNVVVPEFAPVPSTPAATTTAAATTTTTTELKTTAATASSTSTEAPQKPKKSPKPKDKSKAARAPAPTTAPTGIVFTSDQYVQIGCDLRDLATLQDSLTRAVGGDLSSCTFLFVAEVSITYMETPGADAVIQWASSLGDSEFVLLEQLLPSGPTHPFASTMLSHFHKLNTPIKSVDVYPTVASQVERFRSRGWGSGDVRVWTLWEAWADAEDTFVNAAERRRLDEVEPFDEWEEFALFASHYCVVRARTVARDGQNKKKERGIPNGRELGLPVEKVKVRWDDVPGQRGQRRFAAGAVLTSSSPSSEKKEEVKLLNVMGLGTKSRLQNCDVYGRKKVGDADEADGTDEEKTAVPFTFREGGPSTRMCHSLTDFGTAQLLVGGRASPSTPLKDCWLLEKTNGSESEWAWKRTNDLPIPLYRHSVTRLGKTDMALLAGGRGVADIFPDWLLYEPKLGWIRCEIAGDVKPTSVYGATLACLRQESDSFSGVFTGGLSDDGLIADQLLAWNLDVSNSSRPVVTFVPLQVKSGDDGREEALSRLLLTRFGASCLPQSRTDFLVFGGVIKDHLLDMEDEILLCSLKGDGELTITRRLVPEAANAKSPSHPGPLLLVGTSPVVTPDDGSLMIVGGGATCFSMGTFWNKGISTLELALPAAVENEASPIPAYGWVHEKTVDIIPGEPRSLPLRNQAPNGAEGNANGSVSVRIQPIPRVRLENAEDFARIVREGRPVVLEGLNLGDCVSQWGNGDYVAKKVGTDRKVVIHESTTPAMDFTTKNFRYVTTEFGDFMRRVEKGDRLYLRALSTDKPTEKPAVLSDDFPSLATDFVLPPELALVGDRLFSSVLRVSGPVNMWLHYDVMANVYCQIGGSKRMILFPPSDVEHLGFAPGASSSSIDVFSTLFGESSDSRYLAQVTHPHEAVMTPGDVLFLPPLWLHTATPTSDSSIAVNVFFRDLEGGCYAAGKDVYGNRDLAAYEKGRTDLTRIANSFQKLPAEAREFYLLRLADELRRKAKGAQ
What is the function of this protein?
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.  May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity).
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 4, tRNA-yW synthesizing protein 4, Leucine carboxyl methyltransferase 2, tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LCMT family.
Protein: EMRY_ECOLI
Sequence: MAITKSTPAPLTGGTLWCVTIALSLATFMQMLDSTISNVAIPTISGFLGASTDEGTWVITSFGVANAIAIPVTGRLAQRIGELRLFLLSVTFFSLSSLMCSLSTNLDVLIFFRVVQGLMAGPLIPLSQSLLLRNYPPEKRTFALALWSMTVIIAPICGPILGGYICDNFSWGWIFLINVPMGIIVLTLCLTLLKGRETETSPVKMNLPGLTLLVLGVGGLQIMLDKGRDLDWFNSSTIIILTVVSVISLISLVIWESTSENPILDLSLFKSRNFTIGIVSITCAYLFYSGAIVLMPQLLQETMGYNAIWAGLAYAPIGIMPLLISPLIGRYGNKIDMRLLVTFSFLMYAVCYYWRSVTFMPTIDFTGIILPQFFQGFAVACFFLPLTTISFSGLPDNKFANASSMSNFFRTLSGSVGTSLTMTLWGRRESLHHSQLTATIDQFNPVFNSSSQIMDKYYGSLSGVLNEINNEITQQSLSISANEIFRMAAIAFILLTVLVWFAKPPFTAKGVG
What is the function of this protein?
Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs.
What are the official names of this protein?
Probable multidrug resistance protein EmrY.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EmrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS6_AZOVD
Sequence: MRHYEIIFLVHPDQSEQVGGMVERYTKLIEEDGGKIHRLEDWGRRQLAYAINNVHKAHYVLINVECSGKALSELEDNFRYNDAVIRNLVIRRDEAITGQSEMLKAEENRSERRERRERPEHGGHEGLDGDSDKADE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RL20_DINSH
Sequence: MSRTKGGTVTHARHKKVTDAAKGYYGRRKNTFKVARQAVDKANQYATRDRKNRKRQFRALWIQRINAAVRAHDEALTYSRFINGLSLAGIEVDRKVLADLAVHEPEAFSAIVDQAKAALPA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RS6_FRAP2
Sequence: MKHYEIVLMIHPDQSEQLDAMLSKYRGIIEEKGGKIHRFEDWGRRQLAYPIEKLHKAHYVLFNVECDVESLEKLQENLKYNDAVLRRLVISKKEAVTEPSIMMETNEKEVI
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: MURD_THEP1
Sequence: MRIGFLGFGKSNRSLLKYLLKHQEAKFFVSEAKTLDGETKKFLEEHSVEYEEGGHTEKLLECDVVYVSPGIKPDTSMIELLSSRGAKLSTELQFFLDNVDPKKVVGITGTDGKSTATALMHHVLSERGFKSFLGGNFGTPAVEALEGEYDYYVLEMSSFQLFWSERPYLSNFLVLNISEDHLDWHSSFEEYVDSKLKPVFLQTEGDLFVYNKHIERLKDLEGVRSRKIPFWTDENFATEKELIVRGKRYTLPGNYPYQMRENVLAVSVLYMEMFNELESFLELLRDFKPLPHRMEYLGQIDGRHFYNDSKATSTHAVLGALSNFDKVVLIMCGIGKKENYSLFVEKASPKLKHLIMFGEISKELAPFVGKIPHSIVENMEEAFEKAMEVSEKGDVILLSPGGASFDMYENYAKRGEHFREIFKRHGGDEV
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_MYCTA
Sequence: MGRLFGTDGVRGVANRELTAELALALGAAAARRLSRSGAPGRRVAVLGRDPRASGEMLEAAVIAGLTSEGVDALRVGVLPTPAVAYLTGAYDADFGVMISASHNPMPDNGIKIFGPGGHKLDDDTEDQIEDLVLGVSRGPGLRPAGAGIGRVIDAEDATERYLRHVAKAATARLDDLAVVVDCAHGAASSAAPRAYRAAGARVIAINAEPNGRNINDGCGSTHLDPLRAAVLAHRADLGLAHDGDADRCLAVDANGDLVDGDAIMVVLALAMKEAGELACNTLVATVMSNLGLHLAMRSAGVTVRTTAVGDRYVLEELRAGDYSLGGEQSGHIVMPALGSTGDGIVTGLRLMTRMVQTGSSLSDLASAMRTLPQVLINVEVVDKATAAAAPSVRTAVEQAAAELGDTGRILLRPSGTEPMIRVMVEAADEGVAQRLAATVADAVSTAR
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: FOLD_ORITI
Sequence: MTVIMDGKKLAELRLVETKNDLLALKDKYQITVKLVIILVGNNDASLIYVNNKVAKAKAIGMDSEIIRLFEFIEEKKLLSVIDDLNCDSTVHGIIVQLPLPPHIDALKIFARIDSRKDVDGLNPINIGYLNIGANHGLIPCTALGCIDLLQYYVTDLKGKHVVVIGKSNIVGKPLSALLLRHSCTVTICHSATVDLALHTRTADIVISAVGKANFLTNKHFSGNLAFIDVGISHIYDLQTHKRKLVGDGDFLKIKDLVKFITPVPGGVGPMTVAYLLKNTLTAAKLIYASIIDNDDEKHLC
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL23_BACC4
Sequence: MRDPRDIIKRPVITERSMEMMAEKKYTFDVDVKSNKTEVKDALEAIFGVKVEKVNIMNYKPKAKRVGRHAGFTSRRRKAIVKLTADSKEIEIFQGV
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: EFG_THIDL
Sequence: MARKTPIERYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTCFWKGMDLSLPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWRQANKYKVPRLAFVNKMDRTGANFFKTTSQMEGRLGQPVPVVFPIGAEENFRGVIDLLKMKAIIWDEASQGMKFEYQDPAELLSDAEKWRSAMVEAAAEANEELMNRYLESGELSEEEIKAWLEKRVLNAEQILAYALRTAFKNKGVQAMLAVIDFLPSPVDIPPCNGTDDNEHDTVRRASDDEKFSALAFKLMTDPYVGQLTFIRVYSGILQSGDTVYNPIKGKKERIGRFVQMHANQRDEIKEVRAGDIAPAIGLREITTGETLCDPESIITLEKMVFPEPVISQAVEPKTKADQEKMGIALQRVAQEDPSFRVKTDEESGQTIISGMGELHLEILVDRMKREFGVEANVGKPQVAYRETIRKTVDDVDGKQAKHSGGRGHYGHVVIAMYRLDRESKPKGYDCMNDIKGGVSPGEYIPPVDNGIHEQLNSGVLAGYPVVDVKVTLHFGSYHEVDSSEQAFKMAASIGFKEGCRKANPVILEPMMAVEVETPEDYAGNVMGDLSSRRGMVQGMDEIVTGGKVIRAEVPLSEMFGYSTTLRSMSQGRATYSMEFKHYAEAPRNVAERSSARVQGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_HYDCU
Sequence: MSRIAKSPITLPSGVDVTINGTDVSVKGSKGALSKTFNHAVSVSLEDGVVTVAPKNESKNAWAQAGTARSIINNMVLGVTEGFEKKLQLVGVGYRAQAQGKVLNLTLGFSHPVNHELPEGVTVETPSQTEIVVKGADKQVVGQVAAEIRGYRPPEPYKGKGVKYADEYILRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RL14_SACEN
Sequence: MIQQESRLRVADNSGAKEILTIRVLGGSGRRYAGIGDIIVATVKDAIPGANVKKGEVVKAVIVRQKKEKRRADGSYIRFDENAAVLIKPSGEPRGTRIFGPVGRELRDKKYMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: DC12A_XENLA
Sequence: MTRRSVSRKRRANPGSGPGEQSDWDHSAHKRKRLPPEKKSLVFYLKSRELKPHNDSTYLHLLRGHAACTLPSILSEREFHLGNLNKVFASQWLNHRQVVCGTKCNTLFVVDVQTGQITRIPILKDREPINGSHQSCGIHAIEINPSRTLLATGGDNPNSIAVYRLPTLDPVCVGDGGHNDWIFSIAWISDTMAVSGSRDGSMGLWEMTDEVVNKSDFQHGLSRVPVYSHISHKALKDIPKESSNPVNCKVRALAFNSNNKELGAVSLDGFFHLWKAEQTLSKLLSTKLPYCRENVCLAYGLEWSLYAVGSQAHVSFLDPRQPPHCAKSVYCREQGSGIRSVSFYEHIVTVGTGQGALLFYDIRAQRFLEDSTGNCRNAKKKGDTLKLSTGKGWLNHNEMWLNYFSDIDCCPNAVYTHCYDSSGTKLFVAGGPLPTGLHGNYAGLWS
What is the function of this protein?
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.  The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus leading to their ubiquitination and degradation.  Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins leading to their ubiquitination and degradation.
What are the official names of this protein?
DDB1- and CUL4-associated factor 12-A, WD repeat-containing protein 40A-A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat DCAF12 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: RF3_DICNO
Sequence: MSDILSQDWRDRRTFAIISHPDAGKTTLTEKLLLFGGAIALAGAVKGRKAAHHATSDWMKMEQERGISVTSSVMQFPYHGKVINLLDTPGHEDFSEDTYRTLTAVDSALMVIDCAKGVEERTIKLMEVCRLRTTPIFTFVNKLDRDGREPMEILDEIERVLHIQCAPVTWPIGMGRSLKGIYHLARDTVYFYTTGKGGASINHGETVVGLDNPRLDTLLPDIIDDFREEIHFLREVGNPFDHEAYLRGELTPVYFGSAISNFGVEEMLTDFAQLAPPPRPHRTTEREVAPQEEKLTGFVFKIQANMDLKHRDRIAFMRVNSGTFRAGMKLWQVRLGREVKIPDALTFLAAEREHAQEAFAGDIIGIHNHGTIRIGDTFTEGESLQFTGIPDFAPELFRRVQLKDPLKMKALLKGLAQLCEEGATQFFKPLIGSDLILGAIGVLQFEVVQQRLETEYNVKCQFESVAVATARWIEAPNDKALKQFIDKNQANLAHDHYEQLVYIAPSRVNLQLTQERFPDIVFSQTRDHLAQ
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides but is not codon-specific.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity).
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERPA_THIDA
Sequence: MNATTEMESPLVFTDSAASKVKSLIDEEGNPDLKLRVFVSGGGCSGFQYGFTFDEAQNADDTVMVKNGVTLLVDSMSFQYLVGAEIDYSEGLEGAQFVIKNPNATTTCGCGSSFSA
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: CPLX4_MOUSE
Sequence: MAFFVKNMISNQVKNLGFGGGSEEKKEEGGTSDPAAAKGMTREEYEEYQKQMIEEKMERDAAFTQKKAERACLRVHLRDKYRLPKSEMDETQIQLAGDDVDLPEDLRKMVDEDQDEEEEKDSILGQLQNLQNMDLDTIKEKAQATFTEIKQSAEQKCSVM
What is the function of this protein?
Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (PubMed:19386896).  Required for the maintenance of synaptic ultrastructure in the adult retina (PubMed:19386896).  Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (PubMed:15911881, PubMed:19386896, PubMed:27335398).  Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (PubMed:22694764, PubMed:27335398).
What are the official names of this protein?
Complexin-4, Complexin IV, CPX IV.
What is the protein family that this protein belongs to?
Belongs to the complexin/synaphin family.
What are the subcellular locations of this protein?
Synapse. Cell membrane; Lipid-anchor. Note=Enriched at the synaptic terminal.
Protein: HLDD_YERPB
Sequence: MIIVTGGAGFIGSNIVKALNNIGYKDILVVDNLKDGTKFVNLVDLDIADYMDKEDFVASIVAGDDMGDIDAIFHEGACSSTTEWDGKYMMDNNYQYSKDILHFCLDRSIPFLYASSAATYGGRTDNFIEDRQYEQPLNVYGYSKFLFDQYVREILPQADSQICGFRYFNVYGPREGHKGSMASVAFHLNNQINAGERPKLFAGSENFKRDFIYVGDVADVNLWFWQNGVSGIFNCGTGRAESFQAVADAVVDYHQSGPVEYIEFPEKLKGRYQAYTQADLTKLRAAGYGKPFKTVAEGVKEYLAWLNRSV
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: H4_ORENI
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.