PharMolix/UniProtQA huggingface dataset:
Protein: S41A3_RAT
Sequence: MVVTQLSLEFRFQGKKLRGFSCELTRSPHGVLPESVLSTTCQVAIPILLSGLGMMTAGLVMNTVQHWPVFRDVKDLLTLVPPLVGLKGNLEMTLASRLSTSANTGQIDDRQERYRIISSNLAVVQVQATVVGLLAAVASLMLGTVSHEEFDWAKVALLCTSSVITAFLAALALGILMICIVIGARKFGVNPDNIATPIAASLGDLITLSILALMSSFFYSHRDTWYLTPLVCIGFLALTPLWIFIAKQNPPIMKILKYGWFPIILAMIISSFGGLILSKTISKHQFKGMAVLTPVICGVGGNLVAIQTSRISTFLHMWSTPGVLPVQMKRFWPNPCFTFCSSEINSVSARVLLFLVVPGHLIFFYLICLVEGQSVTSSKIFVLLYLMAGMMQVVILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLGTSLLALCFLLDWLLRGRANLAELVSELVSVPP
What is the function of this protein?
Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane.
What are the official names of this protein?
Solute carrier family 41 member 3.
What is the protein family that this protein belongs to?
Belongs to the SLC41A transporter family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UCRI_SYNR3
Sequence: MTQISAKDVPGMGRRQFMNLLTFGSVTGVALGALYPVVNYFIPPKASGAGGGTTAKDELGNDVTASGWLADHKEGDRSLVQGLKGDPTYLIVDGPDSIGDYGINAICTHLGCVVPWNAGANKFMCPCHGSQYDATGKVVRGPAPLSLALAHVNVENDNVFVSQWSETDFRTDEKPWWA
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex iron-sulfur subunit, Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein, ISP, RISP, Rieske iron-sulfur protein.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein. Note=The transmembrane helix obliquely spans the membrane in one monomer, and its extrinsic C-terminal domain is part of the other monomer.
Protein: DGK1_ASHGO
Sequence: MANEEELQTAESAFVTGARRYSNDYSESESSSKHSGCSTPVEGTPAEAATTIGARASGGSTTWQRLRQLLMERGSDVHLPVTEIHLKSQEWFGDFITKHEVPRKVFHSSIGFFTLALYVRDVDYRNVRLPLIVGFVHVLLLDVIRLHWPAFNTLYCQVTGLLMRKKEVHTYNGVLWYLLGLIFAFSFFSKDVALVSLFLLSWCDTAASTVGRLYGHLTPRISRNKSLAGSLAAFVVGVISCAVFYGYFVPAYSHVNHPGEIMWNPETSRLSLVQLSLLGGFVASLSEGIDLFNWDDNFTIPVLSAIFMHTIIAFSQR
What is the function of this protein?
CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA).  Controls phosphatidate levels at the nuclear envelope.  May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus.
What are the official names of this protein?
CTP-dependent diacylglycerol kinase 1, Diglyceride kinase 1, DAG kinase 1.
What is the protein family that this protein belongs to?
Belongs to the DGK1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Protein: BST1_ASHGO
Sequence: MCSVLRFQRNMASWVKRHVFTFDLGDIQEKRGSDSGSGQSRSTADRYFNAVFGLGLLLFCIVCMAYLSPFLGSDLPQCRSVTMYPSYALVQGFDRRFSRLGRKYHLYLYREAGKDNGFSDDNEIHLDGIPVLFIPGNAGTYKQVRSIAAATANLYYGEMRDALNNNNTKNLDFFTADFNEDFTAFHGRTMLDQAEYCNDAIRYILSIYELSDKYRASGEPLPTSVLVVGHSMGGIVARVMTTLKNHIPQSINTILTLSSPHSTAPATFDGDILKIYNAMNAFWESKFRDRDKDPFYAENVSVISITGGVLDSVLPADYTSLEGIIPSDNGFTTYTTTIPWVWTPIDHLAIVWCDQLRIVVAKLLLELVDRTSASKTRPLPDRMRLARRSLLSGLESSASADFHLWDNEDYIFQPKVAPGALTTAQEMSPILLNVETYDTLNEYNYLAIPHNEPNLRFSLLTSLENLEELHILFCQNYNEHNSNGPIEYSSRCVSPSQDFIHVPRSFENSKYPSESSVGSASLPFKALHFNQTLLSKYDFIKFRKPSKSSFKDEDFVLVELSTTDWQTTVNCNPFQLLLSSAKFAHNASSAPFIQTFRFPYLSSSLVSYKLDVSYTGENLVFEPFIAQSIDSPFETKWHLRLRDSVTITIHSEAPFIPFESHYDKSVKLRLIAPPDCNINLSLSINWYMTLKFLFIRYRLAVAALPLSLVSFVLANQFALYYSSSFFPDFSTTLRAVTSKFWLKLTLSSILLTPILNISFIQRLIHSLDPSGVNSPFLIRKKNIMTAAYYLGIREIFMCWIGPLLSCITLSLVYMLAFGISTLESCVRRVSCYMSTAISKTRMKEIWLKDECEYEEGLVLRRRIGSGIMILAVVLYVPYQLVFVLLFLVQLNTVIKLNINYFNTKRHSNLRNYNSSYLLLMLCVLPINAPMVFVFLHNFGRRWVTSFRSHHNCLAILPIILLVCDNAGLRIPRSHCIERISKLITIGSFLYLSLYSVIYGIRNLFWAHHLVNLISGWLLFTSLDLTSNN
What is the function of this protein?
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
What are the official names of this protein?
GPI inositol-deacylase.
What is the protein family that this protein belongs to?
Belongs to the GPI inositol-deacylase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: OBP_EHV1B
Sequence: MPSIGPIPTIPDEGSRGSSATAAPRRAMASYRDTTLGGRAEGVAFSAVEDSYTSSVSLARMLYGGDLEEWVRHTRPGVSLEIQSRAPVRFPPPNNPSSRRVTVVRAPMGSGKTTALLKWLGEALDAPDISALVVSCRRSFTRTLAKRFNDAELPGFATYFTSTDYTMAGEPFRRLLVQIESLHRVDDNLLNNYDILVLDEVMSTIGQLYSPTMVHLNKVDALLTRLLKTCPRVIAMDATANAQLVDFLASARGERSVHVIINSFAAPGFSQRDGTLLRTLGTDVLRAALGFVLVDDENGTKVMETDSRPISARLREVNSAGFFGRLMDRLVAGRNVCVFSSTVSFSEIVARFCSQFTDSILVLNSLRPSEDVAFWGGVRVLIYTTVVTVGLSFDTAHFHSMFAYVKPMSHGPDMVSVYQSLGRVRELIHNELLVYVDSSGARAEPIFTPMLLNHVVSRQGGWPAEFSQVTDALCCQFKARCGPAYRTASTRGLALFVRFKYKHFFERCTLASVGDSINILYTLLESNQMRVAIEGCQFPLTAAGFCDFLQDLRLDAYAARKEIKQLRGPGGIAATPTEVFENDDVAVFIQKYLRPGVAHDEILALLVELNSPIVREQFVNVAVLGACLRLPAALESPEVFAGVYKHYASGVVPVISDAGALESVSITPDVNVLARWDLYKSCTRHARDLAWDPSRGGSGLDMSEDFITNTLSADYNRFQSLLVEIAKCNVTPLEMLAAGAVRGVTTALSGRPKSRVPLSKGEHAVSLFKVLWEDVFGAKLAKSTQTFPGGVRVKNLRKDEIVALLESVNVNHSECKTHRELYALLMCNRKLFAGPRYKLRAPKWSRNLCFLELDNTGTCKTPLDAALADLAPSAWPQVYGAVDFDAL
What is the function of this protein?
Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins.  In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication (By similarity).
What are the official names of this protein?
Replication origin-binding protein, OriBP, OBP.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae OriBP family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: PG029_VACCW
Sequence: MNAYNKADSFSLESDSIKDVIHDYICWLSMTDEMRPSIGNVFKAMETFKIDAVRYYDGNIYELAKDINAMSFDGFIRSLQTIASKKDKLTVYGTMGLLSIVVDINKGCDISNIKFAAGIIILMEYIFDDTDMSHLKVALYRRIQRRDDVDR
What is the function of this protein?
Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factors 3/IRF3 and 7/IRF7, transcription factors critical for the induction of interferons alpha and beta.  This blockage is produced through the inhibition of host TBK1, by binding host TBK1 adapter proteins TBKBP1 and AZI2, thereby producing a strong inhibition of the phosphorylation and activation of IRF3 and IRF7.  Acts also as an inhibitor of the cellular response to type I IFN by interacting with host STAT2.  Mechanistically, exerts its inhibitory effect after host ISGF3 complex (composed of STAT1, STAT2 and IRF9) binding to the interferon stimulated response element (ISRE).
What are the official names of this protein?
IFN signaling evasion protein OPG029.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG029 family.
Protein: DAPA_CHLPN
Sequence: MHLLTATVTPFFPNGTIDFASLERLLSFQDAVGNGVVLLGSTGEGLSLTKKEKQALICFACDLQLKVPLFVGTSGTLLEEVLDWIHFCNDLPISGFLMTTPIYTKPKLCGQILWFEAVLNAAKHPAILYNIPSRAATPLYLDTVKALAHHPQFLGIKDSGGSVEEFQSYKSIAPHIQLYCGDDVFWSEMAACGAHGLISVLSNAWPEEAREYVLNPQEQDYRSLWMETCRWVYTTTNPIGIKAILAYKKAITHAQLRLPLSIEDFDLENVSPAVESMLAWPKLRTSVFSYS
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: R7BP_BOVIN
Sequence: MSSAPNGRKKRPSRSTRSSIFQISKPPLQTGDWERRGSGSESAHKSQRALDDCKMLVQEFNTQVALYRELVISIGDVSVSCPSLREEMHKTRTKGCEMARQAHQKLAAISGPEDGEIHPEICRLYIQLQCCLEMYTTEMLKSICLLGSLQFHRKGKEPGGGSKSLDCKIEECAETPALEDSSPSPVDIQQHSWQVSTDIENTERDMREMKNLLSKLRETMPLPLKNQDDSSLLNLTPYPLVRRRKRRFFGLCCLVSS
What is the function of this protein?
Regulator of G protein-coupled receptor (GPCR) signaling.  Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes.  When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits.  When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling.  May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation.
What are the official names of this protein?
Regulator of G-protein signaling 7-binding protein, R7 family-binding protein.
What is the protein family that this protein belongs to?
Belongs to the RGS7BP/RGS9BP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane; Lipid-anchor. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation.
Protein: YIDC_PSEMY
Sequence: MDIQRSILIVALAVVSYLMVLQWNEDYGQAALPAEVSSSTAATPALPDTPADTASTGGDDIPTAVAEPTAAAVAPTAAASDELIRVKTDVLDLAIDPRGGDIVQLRLPQYPRRQDRPDVPFQLFDNGSERTYLAQSGLIGQNAPDKSSGRALWSSEKQSYEMADGQDSLVVDLTYSENGVSYIKRYSFKRGLNPQCSAREQQLKKPGCVDPSAYQVDVRYLIDNQSDQAWSGNLFAQLKRDNSGDPSSTTATGTATYLGAALWTSDEPYKKVSMKDIDKQSFKETVQGGWVAWLQHYFVTAWVPSKDSTNLVQTRKDSQGNYIVGFTGPAVQVAAGAQGETGAILYAGPKLQEHLGKLSPGLELTVDYGFLWFLAQPIFWLLEVIHGLLGNWGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWMFWITDLSIKDPFFILPIIMGATMFIQQQLNPTPPDPMQARVLKLMPIIFTFFFLWFPAGLVLYWVVNNILSIGQQWYITRKIEAAAKPANA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RLMN_PROM1
Sequence: MTKLPKLSSNSSLLGLSSEDLEEFARQEGEKSFRGRQIHEWIYQRGAKSLDSISVLPKKWRDSLVRKGIQIGRLDEINRVVAEDETLKLLMGTFDGEIVETVGIPTDKRLTVCVSSQIGCPMGCKFCATGKGGLNRSLDVNEIVDQVISVRETMNRRPTHVVFMGMGEPLLNIQNVLDSIECLTSDIGIGQRKITVSTVGIPNTLSDLAKLAQDRLGRVQFTLAVSLHAPNQTLRELIIPSASSYPINSLLKDCKKYIDLTGRRVSFEYILLGGLNDKDIHAEQLANLMRGFQSHVNLIAYNPIAEENFKRPSQSRVNAFRELLENRGVAVSVRASRGRDKDAACGQLRRQTIDKIKIN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_ACTP7
Sequence: MAWVQIRLNSTDKQAEQISDFLEEIGAVSVTFMDSQDTPIFEPLPGETRLWGNTDVVGLFDAETDMKAIVEALIASRLVEADFVHKIEQIEDKDWEREWMDNFHPMQFGKRLWICPSWREVPDPNAVNVMLDPGLAFGTGTHPTTALCLQWLDSLDLTGKTVIDFGCGSGILAIAALKLGAKQAIGIDIDPQAILASGNNAEANGVADRLQLFLAKDQPQDLQADVVVANILAGPLKELAPNIITLVKPQGDLGLSGILATQAESVCEAYAPDFNLDPVVEKEEWCRITGVKK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_RICB8
Sequence: MFITSLKNQKEFELINKLGKKFHEKYFILVIAKNIPKIFLESKYNIFLGIKVSKKLNKKAVVRNKIKRRIKHLIRLICNNSNLKKLAMIIIPRKGFDTADFSVLNHELSKAILDFYNPKK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: NPIA7_HUMAN
Sequence: MFCCLGYEWLSGGCTTWHSAWVINTLADHRHRGTDFGGSPWLLIITVFLRSYKFAISLCTSYLCVSFLKTIFPSQNGHDGSTDVQQRARRSNRRRQEGIKIVLEDIFTLWRQVETKVRAKIRKMKVTTKVNRHDKINGKRKTAKEHLRKLSMKEREHREEERQVSEAEENGKLDMKEIHTYMEMFQRAQALRRRAEDYYRCKITPSARKPLCNRVRMAAVEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSIIDNSLSLKTPSECVLYPLPPSADDNLKTPPECLLTPLPPSALPSADDNLKTPAECLLYPLPPSADDNLKTPPECLLTPLPPSAPPSADDNLKTPPECVCSLPFHPQRMIISRN
What are the official names of this protein?
Nuclear pore complex-interacting protein family member A7.
What is the protein family that this protein belongs to?
Belongs to the NPIP family.
Protein: AMIB_BUCAP
Sequence: MIDPGHGGQDPGAINSLGLQEKKITLKIGIKLKNLLQNSDLFYPVLTRNDDSYVSLKKRRDFLKNNHVSFLISIHADSSKKRYVSGASIWITTNDRMHREINNFIKNREENIYFPKNIQNLIQKNKHDFFLKKTVLDLQFNNFQKMEINLSRYIFQQLKKIIKLDKINLNYASLGILSSINTPSMLIETGFITNFLEEKKLRTNKYQNKIANAIYIALKNYFQDRLLSNLRNT
What is the function of this protein?
Cell-wall hydrolase involved in septum cleavage during cell division.
What are the official names of this protein?
Putative N-acetylmuramoyl-L-alanine amidase.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDHK_JASNU
Sequence: MNSIEFPLLDQTVQNSVFSTTLNDLSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAVIDAITKLRKKISREIYEDRIRSQQANRCFTTNHKFHVGRSMNTGNYDQGFLYQPPSTSEIPTETFLK
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: Y803_PSEMY
Sequence: MMLSIPDVLNAEQLQQCRAALEGGNWQDGRLTAGHQAVNVKANQQLAQDDPLTQQLGDFILACLAQHPRFMAAALPLKVVPPRFNRYAEGGTYGDHIDNAVFSVPGTPHRIRADLSATLFFSEPEEYEGGELVVQDKRIKLPAGHLILYSSGSLHRVEPVTRGARLASFFWVQSLVRQDEQRSVLLELDDSIQALRQQVPDSPELVRLTGIYHNLLRQWTQT
What are the official names of this protein?
PKHD-type hydroxylase Pmen_0803.
Protein: RAE1L_RAT
Sequence: MSLFGTTSGFGTGGTSMFGSTTTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLNSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPVAACGFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAEELKPRNKK
What is the function of this protein?
Plays a role in mitotic bipolar spindle formation.  Binds mRNA.  May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
What are the official names of this protein?
mRNA export factor, Rae1 protein homolog, mRNA-associated protein mrnp 41.
What is the protein family that this protein belongs to?
Belongs to the WD repeat rae1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited from interphase nuclei to spindle MTs during mitosis.
Protein: TOLB_RHOPA
Sequence: MSFDLNRRQLMISAATAAGALALGPARDAFGQARVQITEGNVAPLPIAIPNFVAGTPSDAEVGTGVSQVITNNLKRSGLFAPIDQAAYLEKITNIDVPPQFKSWASINAQALVTGRMTRQGDGRLKAEFRLWDVATGQQLAGQQYFTSPEYWRRIAHIISDQIYERLTGEKGYFDSRVVFIDESGPADRRVKRLALMDQDGANVRYLTRGSDLVLTPRFSPTNQEITYMEFGQGEPRVYLFNVETGQREIVGNFPGMSFAPRFSPDGQRIIMSLQQGGNSNLFVMDLRSKATTRLTDTPAIDTSPSYAPDGSRICFESDRGGKPQIYIMPASGGQAQRISFGDGSYSTPVWSPRGDYIAFTKQGGGQFAIGIMKPDGSGERILTSGFHNEGPTFAPNGRVLMFFRDPGGNAGPSLFTVDVSGRNELRVPTPGYASDPAWSPLLS
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: IBP2B_DANRE
Sequence: MSLALLCSLLLVHGSLGEIVFRCPSCTAERQAACPKLTTSCEIVREPGCGCCPVCARQKGELCGVYTTRCGSGLRCYPSANSELPLEQLIQGLGRCENKVDLEPTMTNQESAAHSGEVNGTRSPPMKKPGKDYQYIKEIAVNKHHNNKRTRMYNTQDDPKTPHPKQSQCQQELDKVLENISRMAFHDNKGPLENLYDLKFPNCDKTGQYNLKQCHMSTHGQRGECWCVNPYTGVQIPSSDKVRGDPNCSQYYGGPELEPPTAQQK
What is the function of this protein?
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.  They alter the interaction of IGFs with their cell surface receptors.
What are the official names of this protein?
Insulin-like growth factor-binding protein 2-B, IGF-binding protein 2-B, IGFBP-2-B, IGFBP-2b.
What are the subcellular locations of this protein?
Secreted.
Protein: NDA8B_ARATH
Sequence: MSSAVDATGNPIPTSAVLTASAKHIGMRCMPENVAFLKCKKNDPNPEKCLDKGRDVTRCVLGLLKDLHQKCQKEMDDYVGCMYYYTNEFDLCRKEQEAFEKVCPLK
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-B.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA8 subunit family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion intermembrane space.
Protein: RSMC_ECOSM
Sequence: MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPARLDTAASRAHTQQFHHWQVLSRQMGDNARFSLVATANDVADCDTLIYYWPKNKPEAQFQLMNLLSLLPVGTDIFVVGENRSGVRSAEQMLADYAPLNKVDSARRCGLYFGRLEKQPVFDANKFWGEYNVDGLTVKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSVAFARHSPKIRLTLCDVSAPAVEASRATLAANGIEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPDVLDETFGFHEVIAQTGRFKVYRAIMTRQAKKG
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMO_HUMAN
Sequence: MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTELMDADSDF
What is the function of this protein?
G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling.  Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched.  When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes (By similarity).  Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253).  Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
What are the official names of this protein?
Protein smoothened, Protein Gx.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium.
Protein: NU4LM_CANLU
Sequence: MSMVYINIFLAFILSLMGMLVYRSHLMSSLLCLEGMMLSLFVMMSVTILNNHLTLASMMPIVLLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: E321_ADE03
Sequence: MISTTIFIITSLAAVTYGRSHLTVPVGSTCTLQGPQEGYVTWWRIYDNGGFARPCDQPGTKFSCNGRDLTIINITSNEQGFYYGTNYKNSLDYNIIVVPATTSAPRKSTFSSSSAKASTIPKTASAMLKLPKIALSNSTAAPNTIPKSTIGIITAVVVGLMIIFLCIMYYACCYRKHEQKGDALLNFDI
What is the function of this protein?
E3 proteins seem to be dispensable for virus growth in tissue culture cells.  They are potentially important for virus growth under special conditions; E3 region may help adenoviruses to evade the immune surveillance of the host.
What are the official names of this protein?
Early E3 20.5 kDa glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E3_20 family.
Protein: RRF_RHOE4
Sequence: MIDEALFEAEEKMEKAVTVAKDDLGSVRTGRANPGMFSRIVIDYYGSITPITQLASINVPEARMVIVKPYEASQLNAIETAIRNSDLGVNPSNDGSIIRISVPQLTEERRRELVKQAKSKGEDSKVTLRNIRRKAMDELGRIQKDGEAGEDEVGRAEKELDKTTAKYVHTVEELVKHKEAELMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.