PharMolix/UniProtQA huggingface dataset:
Protein: PROA_LEGPC
Sequence: MNIDIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLANDVRKVADLPNPLGVNLLEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIKNTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKIINNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYQVLDKNYPKQLLIKAKPQDFGHEFLDYKLAIKTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVDAAAVYANASTSFTDGGEFGLGAEIGISTQKVHARGPMGLDALTSYKWVIRGTGQIRN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_SHEB8
Sequence: MAELKNDRYLRALLKEPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVTLQPLRRYDLDAAILFSDILTVPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLSIPDPEDELGYVMKAVSTIRRELNGAVPLIGFSGSPWTLATYMVEGGSSKTFEKIKKMAYAEPMALHMLLDKLADSVILYLNAQVANGAQSLMIFDSWGGALSHSAYREFSLHYMQKIIDGLTRFADGRKVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVGHILAGYGEGTGHVFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_RHIME
Sequence: MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHDVIDGKGVLNNRISEYIFTHLNKIGIPTHFIRRLNMREQLIKEVEIIPLEIVVRNVAAGSLAKRLGIEEGTVLPRSIIEFYYKADALDDPMVSEEHITAFGWASPQELDDIMALAIRINDFLSGLFLGVGIQLVDFKVECGRLYEGDMMRIVLADEISPDSCRLWDIETKEKMDKDRFRRDMGGLVEAYQEVARRLGIINENEPPRGSGPVLVK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: U6A_CONER
Sequence: DDCIKPYGFCSLPILKNGLCCSGACVGVCADL
What is the function of this protein?
Delta-conotoxins bind to site 6 of voltage-gated sodium channels and inhibit the inactivation process.  This toxin inhibits sodium channel inactivation in neuronal membranes from amphibians and mammals (Nav1. 2a/SCN1A, Nav1. 3/SCN3A and Nav1. 6/SCN8A) upon binding to receptor site 6.
What are the official names of this protein?
Delta-conotoxin EVIA, Delta-EVIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPA_DESHY
Sequence: MNLRPEEISSIIKQQIERYDSAVEVVDVGTVIQVGDGIARVHGLEKAMSGELLEFPGGIYGMAMNLEEDNIGCIILGKFTEIREGDQVKRTGRIVEVPVGEAMIGRVVNALGQPIDGKGEIKTDKFRPIENTAPGVVYRKSVHEPLQTGLKSIDAIVPIGRGQRELIIGDRQTGKTAVAVDTIINQKGKDVICIYVAVGQKASTVAGVVKTLADHGAMDYSIVVSATASEPAPMLYIAPYSGCAMGEEFMYNGKHVLIIYDDLTKQAAAYRELSLLLKRPPGREAYPGDVFYLHSRLLERAAKLSPDLGSGSMTALPIIETQAGDVSAYIPTNVISITDGQIFLETDLFNAGFRPAINVGISVSRVGGSAQIKAMKQVAGQLRLDLAQYRELAAFAQFGSDLDKITQMRLTRGERMMEILKQKQYEPMVVEEQVVVLYAAVKGFLDDIPVDKIKSFEEDYLRTMRTTKADLLAKIRTEKALNDELNAEIEKAITEVKEGFLG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DIVIB_LISMO
Sequence: MAENKRVISIENRIPELKKYRKKKLVRHLAILIGIFVILIAITLYFLSPLSKLDKIAVSGNKQLTENEVRKESGLEIGEFVIGISNGKTEDALKKNTLIKDATVSKEGLNDVQINITEFKTIGYQQQDGKYYDVLESGIMLTDQPRQFPIGNDLLFQNFKNGKTLEKMVDQINKLPKDVVSSISEVIYSPTKSDKNHIKLYMNDGNQVSADISTFAEKMQHYPAIVAQLAKGQKGVIDIEVGSYFQSYYQQNAEKKATEEAAKEKKETNE
What is the function of this protein?
Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.
What are the official names of this protein?
Cell division protein DivIB.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. DivIB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: GADH2_PANCY
Sequence: MMKSILALVLGTLSFAALADDQANDALVKRGEYLARAGDCVACHSVKGGQPFAGGLPMATPIGTIYSTNITPDKTTGIGDYSYDDFQKAVRHGVAKNGDTLYPAMPYPSYAVVSDEDMKALYAYFMHGVAPVAQANKDSDIPWPLSMRWPLAIWRGVFAPDVKAFQPAAQEDPVLARGRYLVEGLGHCGACHTPRSITMQEKALSNDGAHDYLSGSSAPIDGWTASNLRGDNRDGLGRWSEDDLRQFLRYGRNDHTAAFGGMTDVVEHSLQHLSDDDITAIARYLKSLGAKDASQTVFTQDDQVAKALWKGDDSQTGASVYVDSCAACHKTDGSRLSALLPGAAWQPGGAGEPDPTSLIHIVLTGGTLPGVQGAPTAITMPAFGWRLNDQQVADVVNFIRGSWGNGAKATVTAKDVASLRKDETVQAHQGNADIKVLEQQQ
What is the function of this protein?
Part of the heterotrimer that catalyzes the conversion of D-gluconate to 2-dehydro-D-gluconate.
What are the official names of this protein?
Gluconate 2-dehydrogenase cytochrome c subunit, GA 2-DH cytochrome c subunit, GADH cytochrome c subunit.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Periplasmic side.
Protein: Y693_STRTD
Sequence: MRNIYDLANELERGIRALPEYKNLVEKKEAIATDAEASALFKEFTDFQEDFYAKMQAGTMPTAEEQAAVQELGQKVEANALLKEYLTAQQSLSVYLNDIERIIFKPLQELNN
What are the official names of this protein?
UPF0342 protein STER_0693.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: RBSD_STAAE
Sequence: MKKSAVLNEHISKAIATIGHFDLLTINDAGMPIPNDHRRIDLAVTKNLPRFIDVLATVLEEMEIQKIYLAEEIKEHNPTQLQQIKQLISSEIEIIFIPHEEMKSNLAHPLNKGNIRTGETTPYSNIALESNVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_STRP8
Sequence: MPELPEVETVRRGLETLVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYLLIDLGQLVLVSHLRMEGKYLLFPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAKSQLSAFFAKRKLGPEPKKETFKLKTFEAALLSSQKPIKPHLLDQTLVAGLGNIYVDEVLWAAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVYGQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRP
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RSMA_SALNS
Sequence: MNNRVHQGHLARKRFGQNFLNDRFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDKLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTMNFGELSAQLGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCQVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPYPVKDIRVLSRITTEAFNQRRKTIRNSLDNLFSVETLTEMGIDPAMRAENISVAQYCQMANYLSENAPLKES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPG_ALKEH
Sequence: MATDAHKETLEFQAEVQQLLHLMIHSLYSNKDIFLRELISNASDAIDKLRFQSLQDESLLEGEGDLRIRVSVDKDARTITVADNGIGMTRDEVAENLGTIARSGTKAFLDQLTGDQQKDAKLIGQFGVGFYSAFVVAEHVTVHTRKAGLGAEHGVRWSSDGKGAYTLENEEVAERGTRVVLTLPESQSEYLDDWRLKGIIRRYSDHIDVPIQMPAQAEDKDEPEDEAEKAEAAETWETVNNTNALWMRPKSEISDDDYKAFYKHVAHDFDDPMVWLHNHVEGRQSYTSLLYIPKNPPFDLYEREPAHGIKLYVRRVFIMEDTEKLMPRYLRFVRGLVDSDDLPLNVSRELLQHNPLLDKIRSASVKRILDRLEKMAKNEPEQYAEFYGNFGKVLKEGVAEDFANRERIAKLLRFSTTQDENETPDVSLDDYIARMKEGQEAIYYVTAESFNAARNSPHLEVFRKKGVEVLLLPDPVDEWVITHLNEYDGKPLKSVAKGGLDLGELEDQAEKKAAEEATESHKDLLEKLKGALEDKVSEVRVSTRLTDSPACLVVGEYDFGMGMQRLLKAAGHAMPQGKPALEINIDHPIVQRMDTGLDDARFSDWAAVLYDQALLTEGGQLEDPAAFVKRVNALLTEQARAGEAKSNAARGD
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_RICRO
Sequence: MSNKKDIAVKISGGKKIREAREKVKSDTLYNLTNAVERLKSASYVKFDPTLEIVMKLGIDSRHSDQMVRGVVNLPAGTGKTVRVAVICKEEREEEAKSAGADLVGSTNIIDEIKAGKINFDVCIATPDVMAAIGSVARILGPKGLMPNPKLGTVTLDIKNAIKNAKSGQVEYRAEKAGIIHAGLGKLSFSDQDLLKNLNAFIEAVIKAKPAGLKGSYLKAMYLSSTMGASVQIDLTSIA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: LACD_STAAN
Sequence: MSKSNQKIASIEQLSNNEGIISALAFDQRGALKRMMAKHQTEEPTVAQIEQLKVLVAEELTQYASSILLDPEYGLPASDARNKDCGLLLAYEKTGYDVNAKGRLPDCLVEWSAKRLKEQGANAVKFLLYYDVDDAEEINIQKKAYIERIGSECVAEDIPFFLEVLTYDDNIPDNGSVEFAKVKPRKVNEAMKLFSEPRFNVDVLKVEVPVNMKYVEGFAEGEVVYTKEEAAQHFKDQDAATHLPYIYLSAGVSAELFQETLKFAHEAGAKFNGVLCGRATWSGAVQVYIEQGEDAAREWLRTTGFKNIDDLNKVLKDTATSWKQRK
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase, D-tagatose-1,6-bisphosphate aldolase, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: ARLY_CLOB1
Sequence: MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIKGSIAHVKMLTNQNIIKEEEKEKILLGLEEILKEIDEGILKIEGDYEDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYAKKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQVVTFRYHLLAYFEMFKRDEKRLENALEILNESPLGSGALAGSTYNIDKEYTAKLLGFRKPVDNFLDGVSDRDYIIELISKFSIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKIGRVYGDLISILTVMKSLPLAYNKDMQEDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKKGFLNATEAADYLVNKGMAFRDAHKVIGEVVIYCEDKNSAIEDLSLEELKQFSDLFCEDIYEFIDYKNSINKGIKKEMGYF
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIE_BORBR
Sequence: MKTLRFPAGLYGITPEWDDTDRLLAAVRAAAAGGMTALQLRRKLADERLRAAQARALAPLCRELGVVFLVNDHWKLALDVGADGAHLGRDDADPATVRAQAGAGLLLGVSCYNDLRRADALLAAGADYVAFGTVFASPTKPEAVHAPLQTLTEARARLLACPAPRPAVVAIGGITPANVSQVAQAGADSAAVISGLFEAPDIQAAARACAAAFSVNP
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: LEPA_ECOBW
Sequence: MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIKAQSVTLDYKASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSAKTGVGVQDVLERLVRDIPPPEGDPEGPLQALIIDSWFDNYLGVVSLIRIKNGTLRKGDKVKVMSTGQTYNADRLGIFTPKQVDRTELKCGEVGWLVCAIKDIHGAPVGDTLTLARNPAEKALPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVETTSREVIYVDSPSKLPAVNNIYELREPIAECHMLLPQAYLGNVITLCVEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQASDMVRVDVLINGERVDALALITHRDNSQNRGRELVEKMKDLIPRQQFDIAIQAAIGTHIIARSTVKQLRKNVLAKCYGGDISRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDNK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YNJB_ECOLI
Sequence: MRHCGWLLGLLSLFSLATHASDWQEIKNEAKGQTVWFNAWGGDTAINRYLDWVSGEMKTHYAINLKIVRLADAADAVKRIQTEAAAGRKTGGSVDLLWVNGENFRTLKEANLLQTGWAETLPNWRYVDTQLPVREDFSVPTQGAESPWGGAQLTFIARRDVTPQPPQTPQALLEFAKANPGTVTYPRPPDFTGTAFLEQLLIMLTPDPAALKEAPDDATFARVTAPLWQYLDVLHPYLWREGKDFPPSPARMDALLKAGTLRLSLTFNPAHAQQKIASGDLPASSYSFGFREGMIGNVHFVTIPANANASAAAKVVANFLLSPDAQLRKADPAVWGDPSVLDPQKLPDGQRESLQSRMPQDLPPVLAEPHAGWVNALEQEWLHRYGTH
What are the official names of this protein?
Protein YnjB.
Protein: PYRG_BARBK
Sequence: MARYVFITGGVVSSLGKGIAAAALAALLQARGYRVRIRKLDPYLNVDPGTMSPYQHGEVFVTDDGSETDLDLGHYERFTGRSANRHDNITTGRIYRNIIERERRGDYLGATVQVIPHVTDEIKNFITTGNEESDFVLCEIGGTVGDIEAMPFLEAIRQLHNELPRQSVVYMHLTLMPYISSAGELKTKPTQHSVKELQSVGIAPDILLVRADRPIPESERCKLSLFCNVRPSAVIQALDVSTIYDVPIAYHKEGLDSEILSAFGIDSAPEPKMDRWEDIAYRIHHPEGEVTIAIVGKYTGLKDAYKSLIEAVAHGGLANKVKVNIEWIEAEIFEKEDPALFLQKVHGILVPGAFGVRGSEGKIRAIQFARNHKIPFLGICFGMQLACIEAVRNLAGIENASSSEFCETKDSVVGLMTEWLKGDVFEKRTASGNLGGTMRLGAFIAQLKKDSHISKIYGTTSICERHRHRYEVNIHYKDILERFGFVFSGMSPDGVLPEAIEYNNHPWFIGVQYHPELKSRPFDPHPLFSSFIAATVEQSRLF
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: NRDR_HAEIE
Sequence: MRCPFCDTEETKVIDSRLVSDGYQVRRRRECGHCHERFTTFEMAELIIPKIIKTDGTREPFNEDKLRSGIQHALEKRPVSADDVEKAINHIILQLRATGEREVPSKLVGKLAMNELKKLDKVAYIRFASVYLSFDDIDQFTIEIEKLKD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: DNAJ_YERE8
Sequence: MAKRDYYEVLGVKKDADEREIKKAYKRLAVKYHPDRNQDENDTGENFKEVKEAYEILTDPQKRAAYDQYGHAAFEQGGMGGGGFGGGGADFTDIFGDVFGDIFGGGRRQRASRGSDLRYNMDLTLEEAVRGVTKEIRIPTLNECDVCHGSGAKPGSSPVTCSTCRGAGQVHMRQGFFTVQQACPTCHGSGQIIKDPCNKCHGHGRVEKSKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKAHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPAETQTGKLFRMRGKGVKSVRGGSQGDLLCRVVVETPVHLSEKQKQLLRELEESFVGAAGEKNSPRSKSFLDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FICD_DANRE
Sequence: MAALAVLRYAGSSPLLWGWGPILFGLLGSVFVLLLPLVGIEEQCCATLKGLALLRCQMWGGIQRPVVHTTSLAVPFTALDLLPQKVKPSKETQLEAKAALQQALEMKKSGKREKAHKLLVHALNMNPEFVEALTELGTILEEEKDVVQADHLYTKALAISPCHEKALVSRDRTLPLVEEIDQRHFGIIDGKVRRLMSIPKGNSALRRVMEETYYHHIYHTVAIEGNTLTLSEIRHIIETRYAVPGKSLQEQNEAIGVDVAMKYINTTLLSRDGAITVNDILEIHRRVLGYADPVEAGRFRVNQVFVGHHIPPHPQDLDKHMQELVQWLNSEETLHLHPVEFAALAHYKLVYVHPFVDGNGRTSRLLMNLILMQASYPPITIRKEQRAEYYAALDTANEGDVRPFIRFIAKCTEMTLDTLLIATTEHAVGLPGASNHACPDCKQTIPVHS
What is the function of this protein?
Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins.
What are the official names of this protein?
Protein adenylyltransferase FICD, AMPylator FICD, FIC domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the fic family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: T23O_BURMA
Sequence: MQPPGDDAAPRCPFAGAHAPDAPHVPEAAGDDVQAGWHRAQLDFSQSMSYGDYLSLDPILDAQHPRSPDHNEMLFIIQHQTSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRELEFILGNKNAQMLRPHAHRPAIHAHLEASLQAPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDRTVETAWLAVYREPNAHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGSTSGAPYLRKMLDVVLFPELWHVRTTL
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: AROC_PSEP1
Sequence: MSGNTYGKLFTVTTAGESHGPALVAIVDGCPPGLEISLADLQHDLDRRKPGTSRHTTQRQEADEVEILSGVFEGRTTGCSIGLLIRNTDQKSKDYSAIKDLFRPAHADYTYHHKYGIRDYRGGGRSSARETAMRVAAGAIAKKFLATQGITVRGYMSQLGPIEIPFKTWESVEQNAFFSPDPDKVPELEAYMDQLRRDQDSVGAKITVVAEGVMPGLGEPIFDRLDAELAHALMSINAVKGVEIGAGFASVAQRGTEHRDELTPEGFLSNNAGGILGGISSGQPIVAHLALKPTSSITTPGRSIDVDGNPVDVITKGRHDPCVGIRATPIAEAMMAIALMDHLLRHRAQNADVQVNTPVLGQR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: ATP6_CANPA
Sequence: MFYSPLDQFELKPLLLITDNLTFSITNYTLYLIIVSLIIIFYSSIIRHNYLGSSRWGVSVIAIYDTILNLVNGQIGRKGGYYFPLIFTIFNFILIANLISMIPYSFAISAQLVAVVSFSLTLWIGNVVLGLYLHGWGFFALFVPSGTPLALVPVLVLIEALSYASRAISLGLRLGANILSGHLLMLILGSLIISLMSSSFLGFVSGIIPILAVVAITILEFGIAIIQAYVFSILLSGYIKDSVELH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase subunit 6, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LYSX_RHOE4
Sequence: MESPPENPRQARRFRKGRFSQVPHISGLILGVFSVLVFLWSISPVLRHILRVPREYIDSYYFDAPDTSLSWALVVALLAAALASRKRIAWWLLTIYLALITLTNIASTIVDKNPNNAVAAVVLLVVIGILIAARPEFYTRVRRGAGWKALGVLIGGMAVATVIGWGLVELFPGDLPQNQRFLWALNRVTAAASVDNEVFDGHPRVFVNTVLGLLGAIALLAAVMTLFRAQRSNNALTGNDESAIRGLIQNFGADDSLAYFATRRDKAVIFAPSGKAAITYRVEIGVCLASGDPIGDPEAWPHAIEAWQDLASQYGWATAVMGASETGATAYKKAGLSVLQLGDEAILRTREFNLNGRDMRPVRQAVTRVRRHGVTVRMRRHRDIPPEDMAAVIIRADDWRDTDTERGFSMALGRLGDHLDGDCLLVEAVMGEGTEDESVVGMLSLVPWGPNGVSLDLMRRKPTAPNGVVELMVSELATRSDEIGVVRVSLNFAVFRSVFEEGSRIGAGPILRIWRSVLVFFSRWWQLEALYRSNVKYQPDWEPRFLCFEDNRELPRVGFASAIAEGFVVLPSFGRKSSQVVKHTGTHAAVPAALVTSEGLHADGSPPDSAPSFTTNGPRRPEQVRVRMNKLAQLADEGIAAYPVAYPPTHTIAAAAKSPEGTRVRIAGRLLRVRDYGGVVFTDVRDWSGDIQVLVDQDNVGREKLAEFAAEFDLGDLIEVSGTIGRSRKGELSLIAVEWRMNGKCLHPLPDKWKGLSDPETRVRQRYLDIALNPKARELLEARSAVVKSLRDSLGGRGYLEVETPILQQVHGGANAAPFLTHINAYNLDLYLRIAPELYLKRLCVAGMEKVFEIGRVFRNEGVDFKHNPEFTILEAYEAHSDYEGMMRMCRELIQAAAVAAFGREIIMRPGPDGELVEVDISGEWPVKTMHGAVAEKLGVDVSPETSLEDLQKLCDANEIPYQSSWDTGAIAQEMYEHLVEDYTEFPTFYTNFPTSMSPLTRPHRSIPGVAEKWDLVAWGVELGTAYSELTDPVDQRNRLTEQSMLAAGGDPEAMELDEDFLQALEHAMPPTGGLGMGVDRIVMLITGGSIRETLAFPLAKPRQ
What is the function of this protein?
Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge.  LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M. tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins).  In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides (By similarity).
What are the official names of this protein?
Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.