PharMolix/UniProtQA huggingface dataset:
Protein: SYY_ANAPZ
Sequence: MEFNSEFLATLCARGYLHQLTDATALDGIMSSGAVTAYIGFDCTANSLHIGSLMQIMLLRYLQRFGHKPIVLLGGATTKVGDPSGKEKTRAMLSEDNISANKEGILRVIKKFLSEDVVVVDNAEWLGNYGYLDFLREIGSKFSVNVMLGLESVKSRLSRDQQLSFLEFSYVLLQSYDFVELHKRYGCILQIGGSDQWGNIVSGIDLARKMGCPQLYGVTTPLLLNSSGAKMGKTADGAIWLDETLYSPYNYWQYFRNVPDQDVGRLLRLFTELPLSEIERLEALKGEELNEAKKILATAVTSICHGAEVALQVENQALKVFEHNDHDELRSITFSRKTLGQGIPISKLLHMWGLEESISAGRRLIRGGGCKINGGVVLDEEKLLNCGDFDDNGGYVAVFCGKKRRLKVVLED
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMUV_JANSC
Sequence: MLTVENIEVTLGATPVLHGIDMVAQPGQVTAIVGHNGSGKTTLLRAMTQETPYTGTIRLDGADLASFKPWELATRRAVLPQASRIAFPFTVLEVVRLGLLAGRDGARKALPQEALARVGLSGFEGRYYQELSGGEQQRVQLARVLAQVWEPVQDGQPRWLFLDEPVSSLDIGHQLEVMEIAREYARGGGGVIAVMHDLNLTAMFADHVVLLADGRCLSAGRPAQVMTDVTLSQAYGCTLQVNTSPPGDATYLLPHLARRTGGAHHARRTG
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MPH3_YEAS6
Sequence: MKNLSFLINRRKENTSDSNVYPGKAKSHEPSWIEMDDQTKKDGLDIVHVEFSPDTRAPSDSNKVITEIFDATEDAKEADESERGMPLATALNTYPKAAAWSLLVSTTLIMEGYDTAILGAFYALPIFQRKFGSQNDKTGEWEISASWQIGLTLCYMAGEIVGLQLTGPSVDLVGNRYTLIIALFFLAAFTFILYFCNSLGMIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWLFGQLFAAGIMKNSQKKYADSELGYKLPFALQWILPVPLALGIFFAPESPWWLVKKGRFDEARRSLRRTLSGKGPEKEILVTLEVDKIKVTIDKEKRLTSKEGSYSDCFEDKINRRRTRITCLCWAGQATCGSILIGYSTYFYEKAGVSTEMSFTFSIIQYCLGICATFLSWWASKYFGRYDLYAFGLAFQTIVFFIIGGLGCSSTHGSKMGSGSLLMAVAFFYNLGIAPVVFCLVSEMPSSRLRTKTIILARNTYNVVSIICSVLILYQLNSKKWNWGAKSGFFWGVLCFCTLIWAVVDLPETAGKTFVEINELFKLGVSARKFKSTKVDPFVVKNPPKDVSHNDPKGDIEASIAEE
What is the function of this protein?
High-affinity uptake of maltose and maltotriose.  Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose (By similarity).
What are the official names of this protein?
Alpha-glucosides permease MPH3, Maltose transport protein 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL22_YERPA
Sequence: METIAKHRHARSSAQKVRLVADLIRGKKVSQALETLTYTNKKAAGLVKKVLESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CH60_BUCTC
Sequence: MAAKDVKFGNEARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPSITKDGVSVAREIELEDKFENMGAQMVKEVASKANDVAGDGTTTATLLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVINAVSELKQLSVPCLDSKAITQVGTISANADETVGTLISEAMEKVGNDGVITVEEGTGLEDELEVVKGMQFDRGYLSPYFINKPETGIVELENPYILMVDKKISNIRELLPILEAVAKSSKPLLIISEDLEGEALATLVVKSMRGIVKVAAVKAPGFGDRRKAMLQDISILTAGTLISEELAMDLEKSTLEDLGQSKRVVITKDTTTIIDGSGSKKDIKNRISQIKQQIQESTSDYDKEKLNERLAKLSGGVAVLKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALVRVAQKISKILGQNEDQNVGIRVALRAMEAPLRQIVSNSGEEPSVVTNNVKDGIGNYGYNAATDEYGDMIKFGILDPTKVTRSALQYAGSVAGLMITTECMVTDLPKEEKSDLSVPPQGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_BURCH
Sequence: MAVQQNKKSPSKRGMHRSHDFLTAAPLAVEPSTGEVHLRHHVSPNGYYRGKKVVKTKND
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: TILS_PSYWF
Sequence: MTTPVCISQAFMDSFHAHHAQLLGKRVWLACSGGRDSLGLALLCRTLFDQGRLPFLPQLIHVNHGMQAANDEWAQQVAQWAQQHDMACQIIGLNLTHKSEQAARDGRYQAMMQLMNQDDVLILGHHQDDQVETLLMRLFNGAGVTGLGAMREWTSKQAHTAQSPPDVNKPRQRIFLWRPWLEISRDQITEYAQRHNLKYIDDPTNVAQSPSKLALQTLNDRAWLRSVLLPHITERYPQASEAMARTAQLMQQASDSIDEQVTQDLAQVALAATEQQSVIALDKLAGLSAPRQAALIHHWLAPYPNQLPPSKRLVDEVLALSFRQDSNHQTCLYFDAGSEQYQVRRYQNKLYRLQHAYAQWLQMMPHQIHLPLAHNAEELSLNLADTDVLSLKQSGLEFDWQLTGVRGLMAHLARLLNSADAKVTPCQLIFEPLPRTIKLALAGRSGRKSGKKLLQALDQPSFMRGSVVLCRLDMMGSDGILQDSSTAVPLFIICIDRIWVLQSQFTALINQLLATEVLSTQILEC
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAD8D_ORYSJ
Sequence: MEHNGTAALGWAARDTSGHLSPFSFTRRVQQEDDVTIKVLYCGICHTDLHIIKNEWGNAMYPVVPGHEIVGVVTGVGAGVTKFKAGDTVGVGYFVDSCRACDSCGKGYENYCPTMVITSNGTDYGGATTQGGFSDVMVVRQDYVVRVPASLPPDGAAPLLCAGVTVYSPMVEYGLNGPGKHLGVVGLGGLGHLGVKFGKAFGMKVTVISSSPAKRGEALGRLGADAFLSSRDGEGMAAAAATMDGIIDTVSAGHPLVPLLSLLKPKGQMVVVGAPAMPLQLPAYAIIEGGKRVAGNGVGSVAECQAMLDFAGEHGIAADVEVVAMDAVNAALGRLERNDVRYRFVVDVAGTMHAAAAAAASS
What is the function of this protein?
Involved in lignin biosynthesis.  Catalyzes the final step specific for the production of lignin monomers.  Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
What are the official names of this protein?
Probable cinnamyl alcohol dehydrogenase 8D, OsCAD8D.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: HEM2_BRADU
Sequence: MAIKYGRPIELREVSRRDGAAASPALDLAIRPRRNRKAEWARRMVRENVLTTDDLIWPLFLIDGNNKREQIASMPGVERLSVDQAVREAERAMKLTIPCIALFPYTDPSLRDEEGSEACNPNNLVCQAVRAIKKEFPEIGVLCDVALDPFTSHGHDGLIADGAILNDETVAVLVRQALVQAEAGCDIIAPSDMMDGRVAAIREGLDQAGLIDVQIMAYAAKYASAFYGPFRDAIGSAKTLTGDKRTYQMDSANTDEALREVELDISEGADMVMVKPGMPYLDVVRRVKDTFAMPTFAYQVSGEYAMIAAAAGNGWLDGDRAMMESLLAFKRAGADGVLSYFAPKAAEKLRTQG
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.  Required for nodule development.
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALAD, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: ACCA_RHOP2
Sequence: MSEPMRSYLDFEKPVAELDSKIDELRALAASGSDIHEEVAKIEEKAVQALNELYATLTPWQKTQVARHPQRPHCVDYIEGLITEFTPLAGDRKFGEDEALIGGFGRFRGESICVIGQEKGSSTETRLKHNFGMARPEGYRKAVRLMDMADRFGIPVLSLVDTAGAYPGIGAEERGQAEAIARSTDACLSLGVPNVAVVIGEGGSGGAIAIATANKVLMLEHAIYSVISPEAASSILWRDGTKAQEAANSMKITAQDLLRFGVIDQILPEPKGGAHRDPAAMIATTGDAIAAAFAELAGLDAGTVRARRRQKFLEIGRKLG
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CML44_ARATH
Sequence: MDCSFITTNDLRRMFKTLDKNQDGLVTLDELLWILDKLGWAEHTPDELELIVGKQSLDLDEFLRFYYDAVLDSKGSKKNIDVVADNDEAIARAFNVFDVNGDGYISAEELRDVLERLGFEEEAKAWDCGRMIRVHDKNLDGFVDFEEFKNMILHV
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML44, Calmodulin-like protein 44.
Protein: CAB2_ECHGR
Sequence: MPSAVEAFLQSVDKDGSGTIDTKELLAALGESGLDEKLVQEFINEHDKDHDGQLNLKELKDFLVPSCGCL
What are the official names of this protein?
Calcium-binding protein 2, Calcium-binding protein II, CaBP-II, EgCaBPII.
Protein: TAP50_TETTS
Sequence: MKLLLQNQNIFQKLKNTLNGCIKKFYDTYQDLEQMQKFEMIVEDKLLFRYSCSQSEMFSAQIQAHYLEKRVLQLTDGNVKYIVNFRDKGVLDKANFFDTPNNSLVIIRQWSYEIYYTKNTFQINLVIDEMRCIDIITTIFYCKLELDFTQGIKGISKSSSFSNQIYEYSAQYYKAIQLLKKLLINDSYISELYNSTKSKQQPRLFIFQSFKPKMNLAEQNLSRQFEQCQQDDFGDGCLLQIVNYTHQSLKQIENKNNSNQIVNGQNEISKKKRVLKSNEDLYKISLQKQLKIFQEEEIELHSQSTIRNQTNQQLETFESDTSKRNSEKILHSINELNTSKQKVNQMNSSQHQIQKLENNNLNKNILNQINENDIKNELEERQQQHLTQSFNSKAQLKKIITLKKNQDILLFKPQEQEGSKKY
What is the function of this protein?
Tethering component of the holoenzyme telomerase ribonucleoprotein (RNP) complex (PubMed:23552895).  Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:23552895).  In the telomerase holoenzyme complex, acts as a hub that anchors the two heterotrimeric subcomplexes with the catalytic core (PubMed:23552895, PubMed:23918804).
What are the official names of this protein?
Telomerase-associated protein of 50 kDa, p50.
What are the subcellular locations of this protein?
Chromosome, telomere.
Protein: Y113_ADE07
Sequence: MAGRAKKKCPWNDSCKTTIKIWPDVRMMLGGWLIACASNKPDPKTWCSSPPSAVLKLPILISSPAASSHPRKRGKEKKERTPTERLAAPARKKQCSAYLAIATG
What are the official names of this protein?
Uncharacterized 11.3 kDa early protein.
Protein: RECF_RICM5
Sequence: MKNIFLHSLSLENYRNFKNLELKTDNTPIILIGENGSGKTNILEAISLFYPGRGLRSAKLADICKTSEDHCLVKALLQSKLGLAEFTTQFKRSSNRRITEYNESKIANNELSKFTSMVWLTPHMEGIFTSSSSDRRKFLDRIVYNFDPKHTELVSKYEYYMHERNKILVEDIRDDNWLKIIEEKMADISNHIANNRLKTLEFMQHAIDDLENEFPKADLSIDGIVEQKILNGEENIVSFITAELYQTRNNDKLLGRTSFGVHKSDFLVKHQKKNILAKFCSTGEQKAILIAIILAEMNYAIKLTKIAPILLLDEVFVHLDDKRRQYLIEFFTGLNMQLWVTTTNLEGIENFATKAQLIKL
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBB_YERE8
Sequence: MNQTLLSDFGTPVERVERAIDALRNGRGVMVLDDESRENEGDMVFAAEAMTVEQMALTIRHGSGIVCLCITDERRQQLDLPMMVANNSSQFQTAFTVTIEAAKGVTTGVSAADRLTTIRAAIADNAKPTDLNRPGHVFPLRGQPGGVLSRRGHTEASIDLATLAGYKPAGVLCELTNDDGSMAHAPEVIEFAKLHDMPVVTIDDLAEYRQSQEKKAS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: RS12_MACCJ
Sequence: MPTINQLVKKPRTSKVKKSTAPALNKGYNSHKKKATDLASPQKRGVCTRVGTMTPKKPNSALRKYARVRLSNNIEVNAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTSGVDGRMQGRSLYGAKKPKEKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: ATPL_STRPS
Sequence: MNLTFLGLCIACMGVSVGEGLLMNGLFKSVARQPDMLSEFRSLMFLGVAFIEGTFFVTLVFSFIIK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNAJ_YERPE
Sequence: MAKRDYYEVLGVSRDAEEREIKKAYKRLAMKFHPDRQSEDKNAEEKFKEAKEAYEILTDAQKRAAYDQYGHAAFEQGGMGGGGFGGGGGGADFSDIFGDVFGDIFGGGRRQQRASRGSDLRYNMDLTLEEAVRGVTKEIRIPTLDECDVCHGSGAKPGSSPVTCPTCHGAGQVQMRQGFFTVQQACPHCHGRGQIIKDPCNKCHGHGRVEKSKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPSGDLYVQVQVKAHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKIPAETQTGKMFRMRGKGVKSVRGGSQGDLLCRVVVETPVSLSEKQKQLLRELEESFVGAAGEKNSPRAKSFLDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCR10_MOUSE
Sequence: MGTKPTEQVSWGLYSGYDEEAYSVGPLPELCYKADVQAFSRAFQPSVSLMVAVLGLAGNGLVLATHLAARRTTRSPTSVHLLQLALADLLLALTLPFAAAGALQGWNLGSTTCRAISGLYSASFHAGFLFLACISADRYVAIARALPAGQRPSTPSRAHLVSVFVWLLSLFLALPALLFSRDGPREGQRRCRLIFPESLTQTVKGASAVAQVVLGFALPLGVMAACYALLGRTLLAARGPERRRALRVVVALVVAFVVLQLPYSLALLLDTADLLAARERSCSSSKRKDLALLVTGGLTLVRCSLNPVLYAFLGLRFRRDLRRLLQGGGCSPKPNPRGRCPRRLRLSSCSAPTETHSLSWDN
What is the function of this protein?
Receptor for chemokines SCYA27 and SCYA28.  Subsequently transduces a signal by increasing the intracellular calcium ions level.
What are the official names of this protein?
C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, Chemokine C-C receptor 9, G-protein coupled receptor 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AGAP3_HUMAN
Sequence: MNFQAGGGQSPQQQQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQWSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSATEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSLL
What is the function of this protein?
GTPase-activating protein for the ADP ribosylation factor family (Potential).  GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.
What are the official names of this protein?
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3, AGAP-3, CRAM-associated GTPase, CRAG, Centaurin-gamma-3, Cnt-g3, MR1-interacting protein, MRIP-1.
What is the protein family that this protein belongs to?
Belongs to the centaurin gamma-like family.
What are the subcellular locations of this protein?
Cytoplasm. Note=In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies.
Protein: IF1_ECOUT
Sequence: MAKEDNIEMQGTVLETLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVELTPYDLSKGRIVFRSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECTC_ALIF1
Sequence: MIVRTLDECRDSERRVASETWESVRMLLKNDNMGFSFHITTIYQDTETHIHYKNHLESVYCMSGEGEIEVVGGETYPIKPGTLYILDKHDEHYLRAYKDKEMVMACVFNPPITGAEVHDENGVYPVLD
What is the function of this protein?
Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.
What are the official names of this protein?
L-ectoine synthase, N-acetyldiaminobutyrate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the ectoine synthase family.
Protein: LYAR_MOUSE
Sequence: MVFFTCNACGESVKKIQVEKHVSNCRNCECLSCIDCGKDFWGDDYKSHVKCISEGQKYGGKGYEAKTHKGDAKQQAWIQKINELIKKPNVSPKVRELLQQISAFDNVPRKKAKFQNWMKNSLKVHSDSVLEQVWDIFSEASSSEQDQQQPPSHTAKPHAEMPITKVPSAKTNGTTEEQTEAKKNKRERKEERQKNRKKEKKELKLENHQENLRGQKPKKRKKNQEAGHEAAGEEAAEASGPPEKKKAQGGQASEEGADRNGGPGEDAAEGQTKTAAGKRKRPKHSGAESGYKKKKMKLPEQPEEGEAKDHEAPSKGKFNWKGTIKAVLKQAPDNEISVKKLKKKVIAQYHAVMNDHHTSEEELLAIFNRKISRNPTFKVLKDRVKLLK
What is the function of this protein?
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity).  Also acts at the level of transcription regulation.  Along with PRMT5, binds embryonic globin promoter (By similarity).  Represses the expression of embryonic globin Hbb-y gene (PubMed:25092918).  In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity).  Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity).  Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity).  In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (By similarity).  Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (PubMed:25735755).  Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (PubMed:19489080).
What are the official names of this protein?
Cell growth-regulating nucleolar protein, Ly1 antibody-reactive protein, Protein expressed in male leptotene and zygotene spermatocytes 264, MLZ-264.
Protein: Y1169_AERHH
Sequence: MYENLKSLGIQEPTSVDSYTLRQEANHDILKIYFKKQKGEFFAKSVKFKYPRQRKTMLVDSGTHEYKDVTEINANLKYVVDELDNLTQGVHVQADPDIKQKILRDLRHLEKVVQNKISEIERDLEKL
What are the official names of this protein?
UPF0325 protein AHA_1169.
What is the protein family that this protein belongs to?
Belongs to the UPF0325 family.
Protein: S18B1_RAT
Sequence: MDTAGPPAPAGTEGDGPGGSTGETSRRLSKEQIFVLVSAASMNLGCMMTYSILGPFFPKEAEKKGASNTTIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPEGPIFIAMCFLVRIVDAIGFGAAITASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLCILPSYESDAGKQSFWKLVTLPKIGLIAFVIISLSSCFGFLDPTLSLFVMKKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPNLRKWFLVFGNLITAGCYMLLGPIPLLHIKSQLWLLVLVLVINGVSAGMSIIPTFPEMLSCAYANGFEDGISTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAIQGLWTLLSGVAMALFYLWEDSTMRRSKAQNILGTEEEQAALLPNDT
What is the function of this protein?
Proton-coupled polyamine antiporter involved in the translocation of polyamines from cytosol into secretory vesicles prior to their release via exocytosis.  Uses the electrochemical proton gradient generated by a V-type proton-pumping ATPase to couple the efflux of protons with the uptake of a polyamine molecule (PubMed:25355561) (By similarity).  Facilitates vesicular storage of spermine and spermidine in astrocytes with an impact on glutamatergic neuronal transmission and memory formation (PubMed:25355561) (By similarity).  Upon antigen stimulation, regulates polyamine accumulation and release in mast cell secretory granules, which in turn potentiates mast cell degranulation and histamine secretion (By similarity).
What are the official names of this protein?
MFS-type transporter SLC18B1, Solute carrier family 18 member B1, Vesicular polyamine transporter, VPAT.
Protein: CYB_LEPAI
Sequence: MTNIRKTHPLMKIINNSLIDLPAPSNISSLWNFGSLLGACLTIQIITGLFLAMHYTADTTTAFSSVTHICRDVNYGWTIRYLHANGASLFFLCLFIHVGRGLYYGSFVLLETWNIGIMLLFSVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGTDLVEWIWGGFSVSKPTLTRFFALHFILPFIISALTMIHLLFLHETGSNNPLGMSSNPDKIPFHPYYTTKDFLGLLLLILLLMTLTLFYPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVVALIMSILILAIMPFLQPNKQQTMMFRPLSQFLFWILVADLLTLTWIGGQPVENPFINIGQMASILYFSLMVFIMPMTCLVENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.