PharMolix/UniProtQA huggingface dataset:
Protein: SYE_PELPD
Sequence: MSDIRVRFAPSPTGYLHVGGARTALFNWLLARKQGGTFILRIEDTDVERSTQESVDAILQGMEWLGLDWDEGPFYQTDNFPLYREYIQKLLDEGKAYRCYCTAEELEAKRELAMKEGRKPKYDGTCRDLTEQPADRPFVVRFRAPQDGGATSFNDLIKGTITFPNDELDDLIVQRSDGTPTYNFCVVIDDAIMKITTVIRGDDHVNNTPRQVQLYQALGFPVPQFAHVPMILGSDKARLSKRHGATSVIAYRDMGFLPEALMNYLVRLGWSHGDDEIFSRDEMVAKFDISNVGRSPSVFNPDKLLWLNAHYIKHGDPQRLADLLVPFLKMRGVDPANGGPQLAVAIKTLQERARTMLEMADSALFYYHAPESYDRTALAKFEKEHLLAVYATVAEKLSAATAVTAAEFDALFKEICAEKGWKMPQVGQPVRIALSGGTHAPGIGEIIVTLGKEETIQRIQRAREFVEKQ
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIR1_HHV2H
Sequence: MANRPAASALAGARSPSERQEPREPEVAPPGGDHVFCRKVSGVMVLSSDPPGPAAYRISDSSFVQCGSNCSMIIDGDVARGHLRDLEGATSTGAFVAISNVAAGGDGRTAVVALGGTSGPSATTSVGTQTSGEFLHGNPRTPEPQGPQAVPPPPPPPFPWGHECCARRDARGGAEKDVGAAESWSDGPSSDSETEDSDSSDEDTGSETLSRSSSIWAAGATDDDDSDSDSRSDDSVQPDVVVRRRWSDGPAPVAFPKPRRPGDSPGNPGLGAGTGPGSATDPRASADSDSAAHAAAPQADVAPVLDSQPTVGTDPGYPVPLELTPENAEAVARFLGDAVDREPALMLEYFCRCAREESKRVPPRTFGSAPRLTEDDFGLLNYALAEMRRLCLDLPPVPPNAYTPYHLREYATRLVNGFKPLVRRSARLYRILGVLVHLRIRTREASFEEWMRSKEVDLDFGLTERLREHEAQLMILAQALNPYDCLIHSTPNTLVERGLQSALKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIALGRQGSWWEMFKFFFHRLYDHQIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNQATLRAITGNVSAILARNGGIGLCMQAFNDASPGTASIMPALKVLDSLVAAHNKQSTRPTGACVYLEPWHSDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRLIRHLDGEKNVTWSLFDRDTSMSLADFHGEEFEKLYEHLEAMGFGETIPIQDLAYAIVRSAATTGSPFIMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVSRQTFDFGRLRDAVQACVLMVNIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKMGLDLESAEFRDLNTHIAEVMLLAAMKTSNALCVRGARPFSHFKRSMYRAGRFHWERFSNASPRYEGEWEMLRQSMMKHGLRNSQFIALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFGGKRLLDAMDGLEAKQWSVAQALPCLDPAHPLRRFKTAFDYDQELLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRLLVHAYKRGLKTGMYYCKVRKATNSGVFAGDDNIVCTSCAL
What is the function of this protein?
Ribonucleoside-diphosphate reductase holoenzyme that provides the precursors necessary for viral DNA synthesis.  Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).  The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability (PubMed:11773417).  Prevents host necroptosis by targeting host RIPK1 and RIPK3, thereby hampering the formation of necroptotic RIPK1-RIPK3 complexes (PubMed:25674983).  May form hetero-amyloid structures with host proteins RIPK3 or ZBP1, thereby preventing RIPK3- and ZBP1-mediated necroptosis (By similarity).  In addition, inhibits extrinsic apoptosis by targeting host CASP8 (PubMed:25674983).
What are the official names of this protein?
Ribonucleoside-diphosphate reductase large subunit, R1, Ribonucleotide reductase large subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
What are the subcellular locations of this protein?
Host cell membrane. Host endosome membrane. Note=Associates with the host cytoskeleton.
Protein: STP2_YEAST
Sequence: MPILSLSSTRNSVLTRIYDYLKALVQQVIVPNVEDDKSSKSTPFEKLEPAKQNHPQKDCCATEKDDLVDVSELFPKQNNKQLSLTSKSSVVPCALNLDNLETPFSIKIDNNGAVTTQLNLDEPILRGPSRGEPAKLQNDLISSPPLEESYINNDQYKALFPSNFLPITPVSSVITPASKKSIDESPLSDEVQGIADESSETLPYICHYCDARFRIRGYLTRHIKKHAKRKAYHCPFFDNSISQELRCHTSGGFSRRDTYKTHLKSRHFTYPEGVKPQDRNKSPGVCTQCGEHFSTSESWVENHIEAGSCKGLPEGYSEGIREKKKTSKMKMIKTSDGQTRFISSDESVSEPALQNKNCIEATVMQSKERPNDKIIPTKTEKNDFGIGTQWFERKQISRPTQTTQSRGPTEVQNLKEWSIISPPILSPQNASSVPQEYQSSRYTLHMDSPALSSASSALSPLSGDPITTTETNKSYPLDSEQSLLEPDKTEEDAINQSKESNMISINEMLQKQMDFELLGENHLKETQDYLALYKKAYGIEF
What is the function of this protein?
Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels.  Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases BAP2 and BAP3.  Binding to promoters is facilitated by DAL81 (By similarity).  Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response.  Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes.
What are the official names of this protein?
Transcription factor STP2.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Localizes to the cytoplasm in its unprocessed form and is targeted to the nucleus after proteolytic processing upon induction by amino acids.
Protein: ENGB_PECAS
Sequence: MTQQYNYHMTRFIISAPDIRHLETDNGIEVAFAGRSNAGKSSALNTLTNQKSLARTSKTPGRTQLINLFQVAEGVRLVDLPGYGYAEVPEQMKIKWQRALGEYLQKRNSLKGLVVLMDIRHPLKDLDQQMILWAVDVKLPVLVLLTKADKLASGARKAQLNMVREAVLPFMGDIQVEAFSSLKKIGVDKLQQKLDNWFSTLQHIEEEQDAE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: ORTA_ACESD
Sequence: MAKKGDWVLIHKIVLSPEERAPQVPDDTKKVPLEMWIKGYLNEDAQIGDQVSITTRTKRVEEGKLLEVNPYYTHDFGKFVPELLKISEQVREITFGGEGNE
What is the function of this protein?
Involved in the ornithine fermentation pathway.  Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine.  It is strictly specific for AKP.
What are the official names of this protein?
2-amino-4-ketopentanoate thiolase alpha subunit, AKP thiolase, AKPT.
What is the protein family that this protein belongs to?
Belongs to the OrtA family.
Protein: SYP_BURTA
Sequence: MKASRFFIGTLKEAPADAEIVSHKLMVRAGMIRRVAGGIYNYLPVGLRSIRKVEAIVREEMNRAGAIELLMPAVQPAELWQESGRWEQYGPELLRFKDRKQNEFVIGPTHEEVVTDIARNQIKSYRQMPVNFYQIQTKFRDEIRPRFGVMRGREFIMKDAYSFDKDHESLKESYKKMYDAYVRIFTRIGLEFRPVAADNGSIGGSGSHEFHVIADTGEDAIAYCPTSDFAANVEAAEALPLLASRAAPAEAMQKVATPGKAKCEAVAELMGIPLERTIKSIVLATDNEGAEPTVWLLMLRGDHDLNEIKTAKLPGLAGYRFATEAEIVEWFGTPPGYLGPIGTKKPVRVVADRTVANMSDFVVGANEVDYHIAGVNWGRDLPEPVIADIRNVKAGDPSPDGKGVLDICRGIEVGHVFQLGTKYSDAMGATFIDESGKAQPMVMGCYGIGVTRILGAAIEQNFDDKGIIWPEAIAPFEVVLCPMGYDRSDAVREAADKLYADLAAAGIDVILDDRGERPGVMFADWELIGVPHRLVIGERGLKDGKIEYQGRRDAEATLLPADSAATAVAEKVRAALAR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1947_MYCTO
Sequence: MTTPEYGSLRSDDDHWDIVSNVGYTALLVAGWRALHTTGPKPLVQDEYAKHFITASADPYLEGLLANPRTSEDGTAFPRLYGVQTRFFDDFFNCADEAGIRQAVIVAAGLDCRAYRLDWQPGTTVFEIDVPKVLEFKARVLSERGAVPKAHRVAVPADLRTDWPTPLTAAGFDPQRPSAWSVEGLLPYLTGDAQYALFARIDELCAPGSRVALGALGSRLDHEQLAALETAHPGVNMSGDVNFSALTYDDKTDPVEWLVEHGWAVDPVRSTLELQVGYGLTPPDVDVKIDSFMRSQYITAVRA
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MT1947.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: UN13B_RAT
Sequence: MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGLSVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKNDEICGTKNPTPHKILLGTRFELPFDIPEEEARYWTYKLEQINALADDNEYSSQEESQRKLLPTAAAQCRHWTYLGWGEHQTFEDPDSAVDDRDSDYRSETSNSAPPPYHTTTQPNASAHQFPMPVPLPQQLFLQGSSRDSCNDSMQSYDLDYPERRALSPTSSSRYGSSCNVSRGSSLLSELDQYHEQDDDGRERDSIHSSHSYGSLSRDGQAGLGEQEKALEVACESQKEKTGESKERDDATVCPPSDLMLHKDLTLGPQESFPEEKASSPFTQARAHWFRAVTKVRLQLQEISDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDLAMSLVQSRKAGITSAMATRTSLKDEDLKSHVYKKTLQALIYPISCTTPHNFEVWSATTPTYCYECEGLLWGLARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVSKVAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQINVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVWIPDARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSHQYQLQEQPLEEPGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDRLCKSADYMNLHFKVKWLHNEYVRELPALQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGGLERDKRDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLIQYADILSKNFPAYCTKERLPCILMNNMQQLRVQLEKMFEAMGGKELDSEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPNARASVAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERVIVLPPLIDQTGTQLILTAAKELSQLSKLKDHMVREETRNLTPKQCAVLDLALDTVKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTAQVHDGKGIRFTANEDIRPEKGAGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNSWTPKYNETFHFLLGNEEGPEAYELQICVKDYCFAREDRVIGLAVMPLRDVAAKGSCACWCPLGRKIHMDETGMTILRILSQRSNDEVAREFVKLKSESRSIEEGS
What is the function of this protein?
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway.  Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity).  Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).  In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity).
What are the official names of this protein?
Protein unc-13 homolog B, Munc13-2.
What is the protein family that this protein belongs to?
Belongs to the unc-13 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Synapse. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.
Protein: DNAJ_TRIV2
Sequence: MARDYYEILGVARDADKEEIKQAYRRLARKYHPDVNKEPGAEERFKEINRAYEVLSEPETRARYDRFGPEGVSGAGVGFQDMSDMGGFADIFESIFSGFAGGGMGGPTQQRRRGGPARGDDLRLDLKLDFREAVFGGEKEIRISHLETCETCSGSGAKPGTRPRTCSTCSGSGQVRRVTRTPFGSFTQVSTCPTCNGTGMVIEDKCDACDGKGTNQVTKKLKITIPAGVDNGTRLRIQQEGDAGQRGGPPGDLYVYLFVNEDEEFQRDGINVISEIKVSYLQAILGCRLEVNTVDGPVELIIPAGTQPNTVMKLENRGVPRLGNPVSRGDHLLTVLIDIPTKVIPEERELLEKLAKIKGDRTGKGGLEGFLGNLFK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMS_AERPE
Sequence: MCGIIGLAFAEGNSVAGALVRGLKRLEYRGYDSMGVAVIEPPGRLVVRKAAGKIGEVVRRTGVLSLRGRVGIGHTRWATHGPPNDVNAHPHTDCGGRVAVVHNGVIRNYASLRRELEARGHRLVSETDTELVAHLIEEYLGRGYSFLEALSLLGRVLRGSYALALLHLGEPDKVYFLRYKSPLVVGLGEGVNAVASDITAVLDVARDVIVLEDGEFGWISPEGVAIYRPRGDGGFEPLPPGALEERVKRVEWTPESASKAGYPHFMLKEIYEQPRALAETFEGIIEDPALLRAAGLVAGAGRLLIVGAGTSFHAGLVGHYYLSRLAGILGHPVVASEHKVYTPGVDGETVVVAVSQSGETYDTLEAVREWRGRGARVIGVTNVVGSALDREADVTLYLRAGPEIGVAATKTFLAQTILLQTLSIAAAGEAGRLTSGETRELTGVLEGAPDAARRAILASEGAAREAASLLKGAGSMYIIGRGLGGRLAMEAALKVKEVSYIHAEAYPAGESKHGPIALVEPGFKVYVVATSDSPEVMGNAIEMKARGASVTVVAPSDLQLDTPEGIEVLKMPPTGGETLLDPYSLTPYFQLLAYHLAVARGYDPDKPRNLAKTVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP1_SMIOO
Sequence: MARYRRHSRSRSRSRYRRRRRRRSRHHNRRRTYRRSRRHSRRRRGRRRGYSRRRYSRRGRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SUCC_KORVE
Sequence: MKIHEYQGKAILRKYGVAVPRGEMVTTREEAERVANDLMHDGAKGVVVKAQIHAGGRGKGGGVKIAKSVDEAGQLAGKILGMTLITHQTGPEGKKVQRLLIEETLPIERELYLSIVLDRSNGKPVFMASAAGGMEIEEVAAKDPNAIIKEWIEPGYGLGAFQARKIAFKLGLKPELIGQAVKFMQALYKTYDETDASLVEINPFITTSDNRLFALDAKFNFDDNGLFRHPDLKDLRDVTEEDPLEVEASKYGLNYIKLDGTVGCMVNGAGLAMATMDIIQYAGGMPANFLDVGGGANAEQVTHAFEILLSDKNVKAVLINIFGGILRVDTLATGVVQAATQTKIQLPIVLRLEGTNVEQGREILQKSGLNFIVAETMKDAAEKVVAAAKGVK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RSCA1_RABIT
Sequence: MSSSPPLDGSDHPAHSSGQSPEAGNPTSLARSVSASVCPVKPDNPDSTEPEAVTALEASDGFQINSKQTDRLPLQGHSPCAAAAAPSSAMPLRHSSEAAGVADSLEASAERRTQGLRFHLHTRQEVNLSITTTRMHEPQMFAGEEGWHPENQNPSQVNDLQQHQEPENARHEAGPRDAPSDTGDLELPGERQQKHEVADREATMRGGRLQQDAGLPDPGKGALPSGHCGRPDSETLMEVDAAEQSLVAVLSSSVGNGSASGLTLGNPLMEVELPTCSPSSEILNGSIPIQDLQPPEGSVEMPGTDRAYGGRASSSSVCGSSQPPAESAEESCSSITTALKELHELLVISSKPASEAAYEEVTCQSEGTAWGQTRVNPSERWTESERRTQDEDRPQVSHAIPECVKTEKLTDASPDTRIEDGENATFQGPGGGLSTDHGAPRSRGSVHESRSVTVTSAETSNQSHRTLGVEISPRLLTGEGDALSQTCEQTKSLLVKDLGQGTQNPAPDRPATREDVCRDAARPSLEVEAPPSHSSGPCILPPLGFPAADIDRILRAGFTLQEALGALHRVGGNADLALLVLLAKNIVVPT
What is the function of this protein?
Mediates transcriptional and post-transcriptional regulation of SLC5A1.  Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1.  Also involved in transcriptional regulation of SLC22A2.  Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity).
What are the official names of this protein?
Regulatory solute carrier protein family 1 member 1, Transporter regulator RS1, rRS1.
What are the subcellular locations of this protein?
Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Localizes at the inner side of the plasma membrane.
Protein: REST_BORBU
Sequence: MPPKVKIKNDFEIFRKELEILYKKYLNNELSYLKLKEKLKILAENHKAILFRKDKFTNRSIILNLSKTRKIIKEYINLSVIERIRRDNTFLFFWKSRRIKELKNIGIKDRKKIEELIFSNQMNDEKSYFQYFIDLFVTPKWLNDYAHKYKIEKINSYRKEQIFVKINLNTYIEIIKLLLNQSRDIRLKFYGVLMAIGRRPVEVMKLSQFYIADKNHIRMEFIAKKRENNIVNEVVFPVFADPELIINSIKEIRYMEQTENLTKEIISSNLAYSYNRLFRQIFNNIFAPEESVYFCRAIYCKFSYLAFAPKNMEMNYWITKVLGHEPNDITTAFHYNRYVLDNLDDKADNSLLTLLNQRIYTYVRRKATYSTLTMDRLESLIKEHHIFDDNYIKTLIVIKNLMLKDNLETLAMVRGLNVKIRKAFKATYGYNYNYIKLTEYLSIIFNYKL
What is the function of this protein?
Catalyzes the conservative, sequence-specific DNA breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate.  Breaks two phosphodiester bonds in a single DNA duplex and joins each end with the opposite DNA strand to form covalently closed hairpin telomeres (PubMed:11804598, PubMed:12753185).  In vitro relaxed-circular, open-circular and linearized plasmids, but not supercoiled DNA, are all substrates (PubMed:11804598).  Cleavage is position-dependent relative to conserved sequence elements (PubMed:12753185).
What are the official names of this protein?
Telomere resolvase ResT.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Found at the end of hairpin DNA molecules in the area equivalent to eukaryotic telomeres.
Protein: BAMC_PSYIN
Sequence: MSKFYKSGRVTTAVIVALSLSACARFDARTQANGDFDYVQTPRGEHYQTAHFTQNEARDIYDIPALTEQQKRIGFLSSNVDIRPPTQLIPVIDGVVLEANNSDKTTVLFNAFNHTENMKDKVWTLLESYIAANNIEVAAKDSNLTQIETGMFRHQQAYGSFLFRTKVVRESSYRFTLNQPQGGQNAALTVEVLSYSEKNDNVDLKVNLTARSKKSIELRLVNDLLKYAYQLKESSELQVANSQPLPIKLGYDDNNQMVWIVDADFIVSWTKLPDLLALLRFEQVDADKNLGYYLVKFKAPNAKYWPENNLNSFELDNAEYFIQLGELNSGSTSITWLDADKKPLADEKVTEIYFSITSKIRDVLLLNENQSKAL
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamC.
What is the protein family that this protein belongs to?
Belongs to the BamC family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: Y358_RHOP5
Sequence: MAKTNPSPPPAPERIAAFRTGLSAETRAAAYLMAKGYRILARRFRTPYGEIDIVAKKRGLVAFIEVKARAKLDDAAYAVTPRQQQRIVDAASAWLMTHPEHADLELRFDALLIAPRSLPRHLIAAFDAST
What are the official names of this protein?
UPF0102 protein RPE_0358.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RF2_MYCA9
Sequence: MDLDCQADIADLDTTLTTVERVLDVDGLRARIKTLEEAAADPNLWDDQARGQQVTSQLSHAQGELRRVEELRSRLDDLPVLYELAEESEDNSVVAEADAERVKLREDIEAMEVRTLLSGEYDEREAVVTIRSGAGGVDAADWAEMLMRMYIRWAEAHKYPVEVFDTSYAEEAGIKSATFAVHAPFAYGTLSVEQGTHRLVRISPFDNQSRRQTSFADVEVLPVVETTDHIDIPEGDLRVDVYRSSGPGGQSVNTTDSAVRLTHIPTGIVVTCQNEKSQLQNKVAAMRVLQARLLERKRQEERAEMDALKGDGGSSWGTQMRSYVLQPYQMVKDLRTEYEVGNPAAVLDGDIDGFIEAGIRWRNRRDD
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B3GA3_HUMAN
Sequence: MKLKLKNVFLAYFLVSIAGLLYALVQLGQPCDCLPPLRAAAEQLRQKDLRISQLQAELRRPPPAPAQPPEPEALPTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPLVSGLLAASGLLFTHLVVLTPKAQRLREGEPGWVHPRGVEQRNKALDWLRGRGGAVGGEKDPPPPGTQGVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGRVVGFHTAWEPSRPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLLSHLVDPKDLEPRAANCTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV
What is the function of this protein?
Glycosaminoglycans biosynthesis (PubMed:25893793).  Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate.  Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans.  Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins.  Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc.  Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation (PubMed:24425863).
What are the official names of this protein?
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3, Beta-1,3-glucuronyltransferase 3, Glucuronosyltransferase I, GlcAT-I, UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase, GlcUAT-I.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 43 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus, cis-Golgi network.
Protein: RK14_COFAR
Sequence: MIQPQTHLNVADNSGARELMCIRIIGASNRRYAHIGDVIVAVIKEAVPNMPLERSEVVRAVIVRTCKELKRDNGMIIRYDDNAAVVIDQEGNPKGTRIFGAIARELRQLNFTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y4596_BACCR
Sequence: MISQSTLFLFILLIIGLIAKNQSLTVAIGVLFLLKFTFLGDKVFPYLQTKGINLGVTVITIAVLVPIATGEIGFKQLGEAAKSYYAWIALASGVAVALLAKGGVQLLTTDPHITTALVFGTIIAVALFNGVAVGPLIGAGIAYAVMSIIQMFK
What are the official names of this protein?
UPF0756 membrane protein BC_4596.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL30_LYSSC
Sequence: MANKLEITLTKSVIGTKPAQRKTVEALGLRKLHQTVEKADNAATRGMLDKVAHLVTVKEI
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: ST7L_DANRE
Sequence: MADSSGSNPQSPGFTEKLKSWLCWSWTYICALWFAMVLTMVYVLRSPLKLQETVNAASVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVENSGSAGLFSSVNGDAEPRSNVAECKVWRNPLNLFRGAEYSRYTWVTGKEPLTYYDMNLSAQDHQTFFLGDTQQLRPEDSVMQKAWRERNPQARIRAAYQAIELNRECAAAYVLLAEEEATTITEAERLFKQALKSAGKDTNLVVYIKRRLAMCARKLGRIKEAVKMMRDLMKEFPLLGMLNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTSALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAVAYAFFHLQHWKRAEGALNLLHCTWEGTFRIIPYPLEKGHLFYPYPGCTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFCAMLAMLTHQFPELMGVFVKAFFSTLFAPLGFFADKMESFMPSCLWHQLTNV
What are the official names of this protein?
Suppressor of tumorigenicity 7 protein-like.
What is the protein family that this protein belongs to?
Belongs to the ST7 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.