PharMolix/UniProtQA huggingface dataset:
Protein: TFIP8_PONAB
Sequence: MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIRRHLTAKSHGRVNNVFDHFSDCDFLAALYNPFGNFKPHLQKLCDGINKMLDEENI
What is the function of this protein?
Acts as a negative mediator of apoptosis.  Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).
What are the official names of this protein?
Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8.
What is the protein family that this protein belongs to?
Belongs to the TNFAIP8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_AERS4
Sequence: MVTIRLQRGGAKKRPFYQVVVSDSRCARDGRFIERVGFFNPVASGSAETLNLDLARIEHWVATGAAVSDRVAKLIKDATKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: GREA_CAMJD
Sequence: MQKEPMSQFGYDKLAAELKDLKDNQRPAVVIEIDTARSHGDLKENAEYHAAREKQALIESRIVELSDLLARAQVIDPSSYEHDSVKFGSSVVIMDLDTEKESKYTLVGICEGDLDKGYISIASPIARAMLGKKEGDDFKVRLPKGESEFEILSINYEPLKF
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: DLX2_HUMAN
Sequence: MTGVFDSLVADMHSTQIAASSTYHQHQQPPSGGGAGPGGNSSSSSSLHKPQESPTLPVSTATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYAPYGTSSSPANNEPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPSEQHPGASASPPCASPPVSAPASWDFGVPQRMAGGGGPGSGGSGAGSSGSSPSSAASAFLGNYPWYHQTSGSASHLQATAPLLHPTQTPQPHHHHHHHGGGGAPVSAGTIF
What is the function of this protein?
Acts as a transcriptional activator.  Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina.  Likely to play a regulatory role in the development of the ventral forebrain.  May play a role in craniofacial patterning and morphogenesis.
What are the official names of this protein?
Homeobox protein DLX-2.
What is the protein family that this protein belongs to?
Belongs to the distal-less homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SPO14_SCHPO
Sequence: MAELHLSFPAYSLCWINNHQMAVGGGGGTTKSGVKNKLKLLSYEDYEPEVGEGHTKFIEHGEIELKHSDDAVMSLGYFKNELIAGINNTIDGKLIDHLRLYGRKDKLFEEKNALRLTDFDNDEQYQRLCLFEPLHDAICISCTNKSFFIISKNDHKVLFEKHGSDVYDVSSTEDKLAIAVDDRVEIYDWNTFELVQVLYMPVERATVRGVSFLPNQSIVAAYNYIKDSKRFASLVRFDYSSKNQLWRFGMIRDLKNAKGVTCFCCDKENGMIIVAGADCSIRFMSLDLTKLSQVYKHSLPVTDMQLSPDSEALVSVSADGLLCLQFVGKFKNLSAVKLEDAGVILRLSLMFPFVLAILYFYLQLLFPDEKLDAIHRFFSFILHIFSKYTIRNYDL
What is the function of this protein?
Required for the formation of transport vesicles from the ER.  This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein sar1.
What are the official names of this protein?
Membrane glycoprotein spo14, SEC12-like protein, Sporulation-specific protein 14.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein. Note=Cycling between endoplasmic reticulum and the early Golgi.
Protein: LOV1C_ARATH
Sequence: MAEGVVLFGVHKLWELLNRESARLNGIGEQVDGLKRQLGRLQSLLKDADAKKHESERVRNFLEDVRDIVYDAEDIIESFLLNEFRAKEKGIKKHARRLACFLVDRRKFDSDIKGITKKISEVIGGMKSLGIQEIIDGASSMSLQERQREQKEIRQTFANSSESDLVGVEQSVEALAGHLVENDNIQVVSISGMGGIGKTTLARQVFHHDMVQRHFDGFAWVFVSQQFAQKHVWQRIWQELQPQNGDISHMDEHILQGKLFKLLETGRYLVVLDDVWKEEDWDRIKAVFPRKRGWKMLLTSRNEGVGIHADPKSFGFKTRILTPEESWKLCEKIVFHRRDETGTLSEVRVDEDMEAMGKEMVTCCGGLPLAVKVLGGLLATKHTVPEWKRVYDNIGPHLAGRSSLDDNLNSIYRVLSLSYEDLPMCLKHCFLYLAHFPEYYEIHVKRLFNYLAAEGIITSSDDGTTIQDKGEDYLEELARRNMITIDKNYMFLRKKHCQMHDMMREVCLSKAKEENFLEIFKVSTATSAINARSLSKSSRLSVHGGNALQSLGQTINKKVRSLLYFAFEDEFCILESTTPCFRSLPLLRVLDLSRVKFEGGKLPSSIGDLIHLRFLSLHRAWISHLPSSLRNLKLLLYLNLGFNGMVHVPNVLKEMQELRYLQLPMSMHDKTKLELSDLVNLESLMNFSTKYASVMDLLHMTKLRELSLFITDGSSDTLSSSLGQLRSLEVLHLYDRQEPRVAYHGGEIVLNCIHLKELELAIHMPRFPDQYLFHPHLSHIYLWCCSMEEDPIPILERLLHLKSVILTFGAFVGRRMVCSKGGFPQLCFLKLEELEELEEWIVEEGSMPLLRALTICNCRKLKLPGGINYITSLKELTIVGMKWKEKLVPGGEDYYKVQNIPNVQFINCDE
What are the official names of this protein?
Inactive disease susceptibility protein LOV1, Disease resistance protein RPP8-like protein 1, Protein LONG VEGETATIVE PHASE1.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family. RPP8/HRT subfamily.
Protein: RNH_SYNWW
Sequence: MKEIIIYTDGACSGNPGPGGWGAVLAYGEHQKEIAGAEADTTNQRMELMAVIEALKAIKGSGWEIRVYSDSAYFINAIQKGWLENWQRNGWKNSKKEDVANQDLWKALIPLLRKNRVRVEKVKGHSGDRWNERCDQLARNAIKSLG
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QACC_STASS
Sequence: MPYIYLIISISTEVIGSAFLKSSEGFSKFIPSLGTIISFGICFYFLSKTMQHLPLNITYATWAGLGLVLTTVVSIIIFKEQINLITIVSIVLIIVGVVSLNIFGTSH
What is the function of this protein?
Multidrug exporter.  Is implicated for the resistance to bacteriocidal quaternary ammonium compounds.
What are the official names of this protein?
Quaternary ammonium compound-resistance protein QacC, Quaternary ammonium determinant C.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TADA_SALTY
Sequence: MSDVELDHEYWMRHALTLAKRAWDEREVPVGAVLVHNHRVIGEGWNRPIGRHDPTAHAEIMALRQGGLVLQNYRLLDTTLYVTLEPCVMCAGAMVHSRIGRVVFGARDAKTGAAGSLIDVLHHPGMNHRVEIIEGVLRDECATLLSDFFRMRRQEIKALKKADRAEGAGPAV
What is the function of this protein?
Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
What are the official names of this protein?
tRNA-specific adenosine deaminase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: RL14_SYNAS
Sequence: MIQMQTVLNVADNSGAKKVACIKVLGGSKRRYAGVGDVIVVAVKEAMPNSKVKKGDVMKAVIVRTAKEVRRQDGSYLKFDDNSAVLISNQMEPIGTRIFGPVARELRARQFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ASTA_TALWO
Sequence: MEQREIILLGLAALAVTYQVIVWIYNAWFHPLSGYPGPKLFGASYLPGLYHRIRGDYVLVHTALHERFGEVIRVSPNELSYINPQAWKDITGQGSGRQDMEKDPLSFGRPMPNAPSIFNAHRMDHSRIRRTMSHAFSASALRRQESLIQSHVKMMIQCLREHNEEVVDMVSWYNFTTFDMFGDLAFGESFGCLTNSLYHPWVKMLIMSMKAGYFIIQAQKYPIFEKVLMSFIPRMMRQRRRDHLALTQAKLAKRMAKPEERPDFLSFILRHQDEATGMSLPELEINASTLIVAGSETTATLLSGCTYYLLRNPRVMEKLLNEVRTTFKSEDEIDITTVNGLKYMLAVLDEALRVYPPAPGNFHRLVPKEGSVICEKFVPGETQVSVCHYAAYHSPCNFHQPDEFIPERFLGESKFENDRRDVLQPFGTGSRACLGRNLAYFEMRLILTHVLWNFDLELMPQSKYWANQKVFAIWDKPELYVKLKPRAGLEVRA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the asperterpenoids, sesterterpenes that exhibit anti-tuberculosis activity (PubMed:30548032).  The first step of the pathway is performed by the sesterterpene synthase astC that possesses both prenyl transferase and terpene cyclase activity, converting isopentenyl diphosphate and dimethylallyl diphosphate into geranylfarnesyl diphosphate (GFPP) and further converting GFPP into preasperterpenoid A, respectively (PubMed:30548032).  The cytochrome P450 monooxygenase astB then dually oxidizes preasperterpenoid A to produce asperterpenoid A along with a minor product, asperterpenoid B (PubMed:30548032).  Finally, the cytochrome P450 monooxygenase astA converts asperterpenoid A into asperterpenoid C (PubMed:30548032).
What are the official names of this protein?
Cytochrome P450 monooxygenase astA, Asperterpenoid biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ZN358_HUMAN
Sequence: MRRSVLVRNPGHKGLRPVYEELDSDSEDLDPNPEDLDPVSEDPEPDPEDLNTVPEDVDPSYEDLEPVSEDLDPDAEAPGSEPQDPDPMSSSFDLDPDVIGPVPLILDPNSDTLSPGDPKVDPISSGLTATPQVLATSPAVLPAPASPPRPFSCPDCGRAFRRSSGLSQHRRTHSGEKPYRCPDCGKSFSHGATLAQHRGIHTGARPYQCAACGKAFGWRSTLLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLRTHGGPRPHKCPVCAKGFGQGSALLKHLRTHTGERPYPCPQCGKAFGQSSALLQHQRTHTAERPYRCPHCGKAFGQSSNLQHHLRIHTGERPYACPHCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKHKRVHEGAAAAAAAAAAAAAAAAAGLGLGPGLSPASMMRPGQVSLLGPDAVSVLGSGLGLSPGTSSGRNPDPGSGPGTLPDPSSKPLPGSRSTPSPTPVESSDPKAGHDAGPDLVPSPDLDPVPSPDPDPVPSPDPNPVSCPDPCSPTRGTVSPALPTGESPEWVQEQGALLGPDG
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 358.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FGM2_GIBZE
Sequence: MQIDHSGDSSEASQAHDSKLHHSHLLGNIPLGLPEARRRVKILVSVDFDAVSGWMGTGQHSRNCLSDYSAGIFAGRVGVGRLLKILDRVGIAEKVTWFIPGHSMETFPLETKAIVDSGAEIALHGYCHEDCTQLDPQQQQDILDKCITLAESLTGKRPVGFRAPLYRIDHDTISLLERKGFLYDTSLSGHDAQLYYLDSGFPLDVVDYSKSASTWMKPSPQPRQLSVVEIPANWYMEDMTPMQFLPNVTNSHGFVSSEAIEKMWKDRFNWLWNWGPDGSGPGDFVFPLVLHPDTSGMAHVAGTIEGMLRWLKEWGPQVEFVTYEEAAREFLLDKEVPA
What is the function of this protein?
Peptidoglycan deacetylase-like protein; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501).  The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892).  During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892).  The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892).  Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892).  The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).
What are the official names of this protein?
Peptidoglycan deacetylase-like protein FGM2, C64 cluster protein NRPS5, Fg3_54 cluster protein FGM2, Fusaoctaxin A biosynthesis cluster protein FGM2.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
Protein: RIMM_GEOUR
Sequence: MSSGNETVLIGKVSATHGVRGQLRITPFSGDVDSLLTLRSIMVKKPGGEMEIFAVAASKAHGKKVIITLKAFDNINQVLHLVGRELYALREQLPELPEDEYYWCDLLGLQVVTEEGESLGELVDIIVTGSNDVYVVQGSGREILIPALADVVLDVDSDAKRMTVSLPEGLLDL
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLAS_FRIAG
Sequence: MASLTSAAVTIPSFTGLKAGRAPTTPSTSIKPPTPMSFSVKASFKEAIGTALVATAAGAVLASNALAVEVLLGGSDGSLAFVPSNIEVAAGETVVFKNNAGFPHNVLFDEDEVPKGVDAGAISMKEEDLLNAPGETFSVTLKEKGTYSIYCSPHQGAGMAGKITVN
What is the function of this protein?
Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I.
What are the official names of this protein?
Plastocyanin, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the plastocyanin family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Loosely bound to the inner thylakoid membrane surface in chloroplasts (By similarity).
Protein: MURI_SALEP
Sequence: MATKLQDENTPCLAATPSEPRPTVLVFDSGVGGLSVYDEIRRLLPDLHYIYAFDNVAFPYGEKSETFIVERVVEIVTAVQQRYPLSLAVIACNTASTVSLPALREKFAFPVVGVVPAIKPAARLTANGVVGLLATRATVKRPYTHELIARFANECQIAMLGSAELVELAEAKLHGDSVSLEELRRILRPWLRMPEPPDTVVLGCTHFPLLRDELLQVLPEGTRLVDSGAAIARRTAWLLEHEAPDAKSTDANIAYCMAMTPGAEQLLPVLQRYGFETLEKLPV
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: BTUD_ECO55
Sequence: MSIVMQLQDVAESTRLGPLSGEVRAGEILHLVGPNGAGKSTLLARMAGMTSGKGSIQFAGQPLEAWSATKLALHRAYLSQQQTPPFAMPVWHYLTLHQHDKTRTELLNDVAGALALDDKLGRSTNQLSGGEWQRVRLAAVVLQITPQANPAGQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNHTLRHAHRAWLLKGGKMLASGRREEVLTPPNLAQAYGMNFRRLDIEGHRMLISTI
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Vitamin B12 import ATP-binding protein BtuD, Vitamin B12-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RHY1_CAEEL
Sequence: MSSSPHTHTLIIMERLSEVRLYSSPMTSVLNSNLSSCLTNAFIPDTVRMASSPLLAWMTLVVIGTLAPVSVFSCLSLKRSVKELLTERSSKLDVLDIFRFVAILWVMLNHTGSEGRIDILDRLPSADAFKSAMHDHPIFGALMGNSALGVEIFLVLSGLLAARSWLRKADEPFFQHWKSFIARRLLRLAPSMFIFVYIAAGPIMNALLPRYSSSMVSACGFWGILSHVTFTSNWQSTPTCMGYLWYLGLDMQLYMVAPIFLNLLHKFPKRGMALTITTIIASMVIRAGYCTAYGTCNQSDVDIPFISYPGQDAETLKSIYAGLWDMYSRPYTKCGPFLIGLLLGYITVSSKYIMVSTTSKTLFRSSLIVAIATIYAILPEYWNPNAGNTLYNTVYTAVFRSVFAMAISGMIAALYFRQEYRPTNPIFAMLAKLTYNAYLLHMPVVYIFNWLPFLQAATSPIHLLLVLPFVAILSFIAALIFYLFIEAPIGHLTSQYATRLGL
What is the function of this protein?
Involved in the response to variation in environmental oxygen levels by inhibiting hif-1-mediated gene transcription in a vhl-1-independent manner (PubMed:16980385).  Plays a role in susceptibility to killing mediated by P. aeruginosa and by pore-forming toxins produced by B. thuringiensis (PubMed:20011506, PubMed:20865124).  Probably by preventing hif-1 transcriptional activity, regulates behavioral responses, such as locomotion speed following acute reoxygenation (PubMed:22405203).  Plays a role in normal egg-laying probably by regulating spermatogenesis and in body morphogenesis (PubMed:16980385).
What are the official names of this protein?
Regulator of hypoxia-inducible factor 1.
Protein: TRMB_LODEL
Sequence: MSSTAPLDSKATEQITTAAESKHNETQATRRKRYREAQEQTRNKHLRFQASPTPEEASPELPSDEVAKLPQKRFYRQRAHSNPFSDHNLEYPVLPSQMDWSTIYPHYTPASLRKVEIADIGCGFGGLLIDLGPQFPESLILGMEIRVQVTNYVQDRLIALREIHKADAYNYDNLGVIRGNAMKFLPNFFTKGQLSKMFFCFPDPHFKQRKHKARIITNTLLSEYAYVLREGGVVYTITDVEDLHNWMVKHLDEHPLFERLSKEWEEQDPCVKIMYNSTEEGQKVARNQGSKYVACYKRLPNPDDCE
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, Transfer RNA methyltransferase 8, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS20_BEII9
Sequence: MANTPSAKKAVRKIERRTAINKSRRSQMRTYIRKVEEAIASGDAAAATSALQSAAPLVMRAAQKGIVHKNTASRKVSRLSKRVKALA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RDUF1_ARATH
Sequence: MMPNSRSATITPTTESTTTTTTTTTTLTTSYWCYSCTRFISVWEDQDANAGVLCPYCNGGFIEEIEDSSNSTVAAIPASTPEVRSVEETHRSIIRRRRSNRRTSFNPVIVLHGGGGGGAGERVENEEGDGATRERRAYEFYYDDGSGSGLRPLPDSVSEILMGSGFERLLEQLSQIEASGNGIGRSGNPPASKSAIESLPRVEISDCHTKAEANCAVCTEVFEAGIEGREMPCKHIFHGDCIVPWLSIRNSCPVCRFELPSDPIQRSNEEEHAVGMTIWRLPGGGFAVGRFNAGVREGERILPVVLTEMDGGGLGSNEGPRRISWVRAHETPEMSRNGGRSGNGGRLRRAVRGMVSFMRRVRPSRGSSNSNVIDLDSDGETRVMNRSTSLIRRFF
What is the function of this protein?
E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid-dependent drought stress responses (PubMed:22405823).  Involved in the positive regulation of responses to salt and osmotic stresses during seed germination and early seedling development (PubMed:23951086).  Possesses E3 ubiquitin ligase activity in vitro (PubMed:22405823, PubMed:23951086).
What are the official names of this protein?
E3 ubiquitin-protein ligase RDUF1, RING and DUF1117 domain-containing protein 1, AtRDUF1, RING-type E3 ubiquitin transferase RDUF1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: ARLY_MARMM
Sequence: MADDTSNDAGQKASSAMWGGRFSAGPSAVMEAINASIDIDQRMADQDIDGSLAHSRMLAATGVISSADAAAIQRGLEQVRSEIHAGDFPWSKALEDVHMNVEARLKEIIGEPAGRLHTARSRNDQVATDFRLWLRDACDRIDAMLAAYQTALVKQAETHADQVMPGFTHLQTAQPVSLGHHLLSYVEVAQRDRGRFADARKRLNESPLGCAALAGTAFPIDREMTASDLGFDRPMANSLDGVAARDFALEVLSAASICAVNLSRFAEEIVLWCTRRFGFATLSDAWSTGSSIMPQKRNPDAAELVRAKPGRIIGSLTGLLTVVKGLPLAYSKDLQEDKAPVFQAIDDLELALLSMAGMAGDLSFFPEALEEAAGEAYSDATDLADYVVRELGKPFRDAHHISGSIVKLAEARGVPLAELSLAEMQSVEPAIDETVFSVLSARASMMSRTSFGGTSPIRVREQVAIWKDRLGC
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SODM1_STAA3
Sequence: MAFELPKLPYAFDALEPHFDKETMEIHHDRHHNTYVTKLNAAVEGTDLESKSIEEIVANLDSVPANIQTAVRNNGGGHLNHSLFWELLSPNSEEKGTVVEKIKEQWGSLEEFKKEFADKAAARFGSGWAWLVVNNGQLEIVTTPNQDNPLTEGKTPILGLDVWEHAYYLKYQNKRPDYIGAFWNVVNWEKVDELYNATK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.  Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site.
What are the official names of this protein?
Superoxide dismutase [Mn/Fe] 1.
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: MYG_NOTNE
Sequence: MADFDMVLKCWGPMEADYATHGGLVLTRLFTEHPETLKLFPKFAGIAHGDLAGDAGVSAHGATVLNKLGDLLKARGAHAALLKPLSSSHATKHKIPIINFKLIAEVIGKVMEEKAGLDAAGQTALRNVMAVIIADMEADYKELGFTE
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SCXN1_MESEU
Sequence: MNSLVMISLALLVMTGVESVRDGYIADDKNCAYFCGRNAYCDEECKKKGAESGYCQWAGQYGNACWCYKLPDKVPIKVSGKCNGR
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.  This toxin inhibits inactivation of Nav1. 6/SCN8A (EC(50)=3. 1 uM) and drosophila DmNav1 (EC(50)=1. 17 uM) (PubMed:21969612, Ref. 2, PubMed:33051988).  It also shows a weak inhibition of inactivation on Nav1. 2/SCN2A Nav1. 3/SCN3A, and Nav1. 7/SCN9A (PubMed:21969612, PubMed:33051988).  The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels (PubMed:21969612).  The toxin has also been shown to dose-dependently stimulates intracellular signaling in DRG neurons through activation of two kinases (type II protein kinase A (PKA-II) and MAP kinases 1/3 (MAPK1/MAPK3)) (PubMed:33051988).  Nav1. 2/SCN2A is strongly suggested to be the target channel predominantly involved in this activation (PubMed:33051988).  In vivo, the toxin induces a dose-dependent thermal hyperalgesia lasting 30-45 minutes (PubMed:33051988).
What are the official names of this protein?
Sodium channel neurotoxin MeuNaTxalpha-1.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: B3A2_MOUSE
Sequence: MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEEDELRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEEEASEAEGFRAPPQQPSPATTPSAVQFFLQEDEGAERKPERTSPSPPTQTPHQEAAPRASKGAQTGTLVEEMVAVASATAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQAAREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKEFSFPRNISAGSLGSLLGHHHAQGTESDPHVTEPLIGGVPETRLEVDRERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPPGAGLEPKSAQDKALLQMVEVAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTKDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNELEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSGSNDSEAGSSSSSNMTWATTILVPDNSSASGQSGQEKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTMRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTEREMKCLDANEAEPVFDECEGVDEYNEMPMPV
What is the function of this protein?
Plays a critical role in male fertility and spermiogenesis.
What are the official names of this protein?
Anion exchange protein 2, AE 2, Anion exchanger 2, Band 3-related protein, B3RP, Non-erythroid band 3-like protein, Solute carrier family 4 member 2.
What is the protein family that this protein belongs to?
Belongs to the anion exchanger (TC 2.A.31) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.