PharMolix/UniProtQA huggingface dataset:
Protein: VEX1_XENTR
Sequence: MEKRPYSVAWLSESSQRKPLCTNVDLLGYKSGNPDLPPNREYNVSLPSRVILPTPDYREKENYCGRNVHNGERSPPVRDQLHFHPAPQELTTSRRTSIEVSAESSTDQRVIGMTDTNKKTISVCDEDAASRARTKFTAEQLEELEKSFKENRYIGSSEKRRLSKVLKLSENQIKTWFQNRRMKFKRQTQDARVEAFFSGLYLPYYGYPDLPTPGYSVQSEFPVLAPQTMAASSIPFGPLHSTVMSPGLHPAIPSANLGSYPCSSMLVRPILNEPTRQRYSPY
What is the function of this protein?
Transcriptional repressor.  Acts in a ventral signaling pathway downstream of bmp4 to antagonize the Spemann organizer and ventrally pattern the embryonic mesoderm.  Represses transcription of the dorsal genes gsc and otx2 (By similarity).
What are the official names of this protein?
Homeobox protein vex1, Homeodomain transcription factor vex-1, Ventral homeobox protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEPA_BACLD
Sequence: MTDKEKRLQRQSRIRNFSIIAHIDHGKSTLADRILEKTAAITQREMKEQLLDSMDLERERGITIKLNSVQLKYQAKDGEEYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPSGDPEAPLQALIFDSLYDAYRGVVAYIRVVQGTVKAGQKIKMMATGKEFEVTEVGVFTPKAVPADELTVGDVGFLTAAIKNVGDTRVGDTITSAENPAPEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSALQYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKIVVDNPSNMPDPQKIDRVEEPFVKATMMVPNDFVGAVMELCQGKRGQFIDMQYLDANRVSIVYEIPLAEIVYEFFDQLKSNTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSFIVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGTKIVARSTIKAMRKNVLAKCYGGDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSGPKS
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PFP3_TRIV3
Sequence: MSAEAPVLGILCGGGPAPGLNGVIAGATLYALRLGWKVIGFMEGFKYLCTGDVDVVKAHTIDLTYDIVSRIHFQGGTIIQTSRANPRKSTELQENVRKCLRALKVRYFLTIGGDDTASSAVSVAQGMDGNEISVISCPKTIDNDLPLPSDQSTFGFHTARSLGMEIIRNLMVDSKSAPRWFLVEAMGRSAGHLALGMAEASGAHLCLIPEEFKQDEIEFEDVVELVEATILKRLAYGKNYGVCVLAEGLVSKMSKKALYRLFGNREPPTDPHGHILLDDAELARSLSEELLKRLGNLGIRITPKKIGYELRCADPVAFDAVYTRELGYGAIDAFLNGHSAALIVRENGQVKPVQFKDLLDPATGRVRTRLVDVTSQSFKVARVYMWR
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis.  Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis.  Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
What are the official names of this protein?
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase 3, 6-phosphofructokinase, pyrophosphate dependent 3, PPi-dependent phosphofructokinase 3, PPi-PFK 3, Pyrophosphate-dependent 6-phosphofructose-1-kinase 3.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Short' sub-subfamily.
Protein: FETP_COXB1
Sequence: MTRRIICQKLGKEADALNYSPYPGELGERIYNHISEQAWQAWLSHQTMLINEYRLSLIDPKARQFLEQEMINFLFGTGSEKPAGYTSEKE
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: UL24_VZVO
Sequence: MSASRIRAKCFRLGQRCHTRFYDVLKKDIDNVRRGFADAFNPRLAKLLSPLSHVDVQRAVRISMSFEVNLGRRRPDCVCIIQTESSGAGKTVCFIVELKSCRFSANIHTPTKYHQFCEGMRQLRDTVALIKETTPTGSDEIMVTPLLVFVSQRGLNLLQVTRLPPKVIHGNLVMLASHLENVAEYTPPIRSVRERRRLCKKKIHVCSLAKKRAKSCHRSALTKFEENAACGVDLPLRRPSLGACGGILQSITGMFSHG
What is the function of this protein?
May participate in nuclear egress of viral particles.  Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1.  Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli (By similarity).
What are the official names of this protein?
Protein UL24 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL24 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus, host nucleolus. Host Golgi apparatus.
Protein: MY1R1_SOLTU
Sequence: MSSVYSDKSSSTPAVTGGGFGGEIMLFGVRVKVDPMRKSVSLNDLSQYEHPNANNNNNGGDNNESSKVAQDEGYASADDAVQHQSNSGRERKRGVPWTEEEHKLFLLGLQKVGKGDWRGISRNFVKTRTPTQVASHAQKYFLRRSNLNRRRRRSSLFDITTDSVSVMPIEEVENKQEIPVVAPATLPTTKTNAFPVAPTVGPIIFPVQIDKSREYPTLLRHDHGNSSMLVGPVPMFSMPNPSTAIDLNANHNSTIEPSSLSLRLSLSLDQGQASSTRHSAYNVMSSFSNGESIIRVA
What is the function of this protein?
Binds selectively to the DNA sequence 5'-[GA]GATAA-3' and may act as a transcription factor involved in the regulation of drought-responsive genes.  Enhances stomatal closure in response to abscisic acid (ABA).  Confers drought and salt tolerance.
What are the official names of this protein?
Transcription factor MYB1R1, Myb-related protein R1, StMYB1R-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Note=Localizes predominantly to the nucleus and, to a lesser extent, to the cytosol.
Protein: NAP1A_ARATH
Sequence: MSNDKDSFNVSDLTAALKDEDRAGLVNALKNKLQNLAGQRSDVLENLTPNVRKRVDALRDIQSQHDELEAKFREERAILEAKYQTLYQPLYVKRYEIVNGTTEVELAPEDDTKVDQGEEKTAEEKGVPSFWLTALKNNDVISEEVTERDEGALKYLKDIKWCKIEEPKGFKLEFFFDTNPYFKNTVLTKSYHMIDEDEPLLEKAMGTEIDWYPGKCLTQKILKKKPKKGSKNTKPITKLEDCESFFNFFSPPEVPDEDEDIDEERAEDLQNLMEQDYDIGSTIREKIIPRAVSWFTGEAMEAEDFEIDDDEEDDIDEDEDEEDEEDEEDDDDEDEEESKTKKKPSIGNKKGGRSQIVGEGKQDERPPECKQQ
What is the function of this protein?
May modulate chromatin structure by regulation of nucleosome assembly/disassembly (By similarity).  Contributes to the regulation of cell proliferation and cell expansion.  May function in nucleotide excision repair (NER).  Involved in somatic homologous recombination.
What are the official names of this protein?
Nucleosome assembly protein 1;1, AtNAP1;1, Nucleosome/chromatin assembly factor group A1.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly located in cytoplasm. Shuttles between cytoplasm and nucleus depending on stage of the cell cycle. Farnelysation favors the location to the nucleus early in leaf development.
Protein: CHX4_ARATH
Sequence: MEFNGDRIPYLRDTWRDANMICGILPINPSSSGLWPSPKLPDPQANIEFWNYMFPHVQIIFLIVTILWQFFHFFLRRLGMIRFTSHMLTGILLSKSFLKENTPARKFLSTEDYKETLFGLVGACSYMMFWFLMGVKMDLSLIRSTGRKAVAIGLSSVLLSITVCALIFFLILRDVGTKKGEPVMSFFEIIFIYLIQCLSSFPVIGNLLFELRLQNSELGRLAMSSAVISDFSTSILSAVLVFLKELKDDKSRLGSVFIGDVIVGNRPMKRAGTVVLFVCFAIYIFRPLMFFIIKRTPSGRPVKKFYIYAIIILVFGSAILADWCKQSIFIGPFILGLAVPHGPPLGSAILQKFESVVFGTFLPFFVATSAEEIDTSILQSWIDLKSIVILVSVSFIVKFALTTLPAFLYGMPAKDCIALSLIMSFKGIFEFGAYGYAYQRGTIRPVTFTVLSLYILLNSAVIPPLLKRIYDPSRMYAGYEKRNMLHMKPNSELRILSCIYKTDDIRPMINLLEATCPSRENPVATYVLHLMELVGQANPVLISHRLQTRKSENMSYNSENVVVSFEQFHNDFFGSVFVSTYTALSVPKMMHGDICMLALNNTTSLIILPFHQTWSADGSAIVSDSLMIRQLNKSVLDLSPCSVGIFVYRSSNGRRTIKETAANFSSYQVCMLFLGGKDDREALSLAKRMARDSRITITVVSLISSEQRANQATDWDRMLDLELLRDVKSNVLAGADIVFSEEVVNDANQTSQLLKSIANEYDLFIVGREKGRKSVFTEGLEEWSEFEELGIIGDLLTSQDLNCQASVLVIQQQQQMI
What is the function of this protein?
May operate as a cation/H(+) antiporter.
What are the official names of this protein?
Cation/H(+) antiporter 4, Protein CATION/H+ EXCHANGER 4, AtCHX4.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DNAK_DELAC
Sequence: KIIGIDLGTTNSXVA
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: DEF_AMOA5
Sequence: MIYPIVPYGESILRQTAAPIELGTDLETLIESMFITMNAAKGLGLAAPQIGKSIQLFVVDVSPFVGDGMVQPDKHRKVYINPVLEIYQPNTITHYEEGCLSIPGIYVDVPRNKRVRIKFFDRNWQAQEEDLVDMPARVVQHEYDHLYGKLHIDYLRADRRLRLKSKLENIKQGRVEVAYKMSFTGNKV
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: ODO1_BACVZ
Sequence: MFQNNMKQRMNWEDFYGPNLGYALELYDQYAEDPDSIDPDLKDMFDELGAPPSQIKEASGTKEQGRVTADLIQKIAAAVKLAEDIRTYGHLNASVNPLRKDPKKSELFPLSDYGLTEEEMKAIPASVICKDAPANITNGLEAIQHLRNTYKRTISFEFDHVHDFEERAWITKMVESGELFRKNSPEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIEGLDALVPVLDDIIAQSVKAGTTNVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNKDLVPSEGSTGISYGWTGDVKYHLGADRQLQDAETKSARITLANNPSHLEFINPIVEGSTRAAQETRTQKGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHIIANNMIGFTTESDESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKRFNKDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKRIFAEKLVSEGLISEEKAQNIETAVTKRIEDAYKKVPAKKEDAVREIELPEPVSNGFPDVDTAIDFDVLRKLNGELINWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSERGTFAQRNLVLHDSETGEEFVALHHLDDCAASFTVHNSPLSEGSVLGFEYGYNVYSPETLVMWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRVERFLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEVQELSESRFKPVYEQSGLSHAYEKVTRVVLSSGKVSIDISDHFNKMEGDKDWLHIARIEQLYPFPAKDTKELFAKLPNLQEIVWVQEEPQNMGAWSYISPYLSEIAPKGVNVQYIGRRRRSSPAEGDPTVHKKEQERIVSDSLTRKN
What is the function of this protein?
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
2-oxoglutarate dehydrogenase E1 component, Alpha-ketoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
Protein: TATA_VIBVY
Sequence: MGGISIWQLLIIAVIVVLLFGTKKLRGIGSDLGGAIKGFKKAMNEEESEKKDADFEPKSLEQQNKQAATESKKDKEQA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: Y3079_CHRVO
Sequence: MSIASWPESERPREKLLSQGAATLNDSELLAIFLRTGIKGVNAVELARRLLQEFGSLSALLAAPLPAFKAKPGLGEAKYAQLMACTELARRALSEQMRLGDALSSPQQVRDYLRLSIGRREVETFVVIFLSAQNRLIEVEEVFKGTLTETRVYPREVLRRALRHNAAALIIAHNHPSGVSEPSSADRVLTDTLKRALELVDIRLLDHFVVTGGHAESFAERGWL
What are the official names of this protein?
UPF0758 protein CV_3079.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: NRFA_SALDC
Sequence: MARKTLRARRFFSLIFPFFFITSVYAEQTPESAKTVTVEAKNETFAPQHPDQYQSWKATSEQSAREDALAEDPRLVILWAGYPFSRDYNKPRGHAYAVTDVRETLRTGAPKTAEDGPLPMACWSCKSPDVARLIQQEGEDGYFHGKWARGGPEIVNDLGCADCHNTASDDFAQGKPALTLSRPYAERAMEAIGKPFDKAGRFDQQSMVCGQCHVEYYFDGKNKAVKFPWDEGMKVENMEQYYDAIAFSDWTNSLSKTPMLKAQHPEYETWSAGIHGKNNVTCIDCHMPKVQNAEGKLYTDHKIGNPFDNFAQTCANCHTQDKASLQKVVAERKQAIHDLKIKVEDQLVHAHFEAKAAWDAGATDAEMKPILNDIRHAQWRWDLAIASHGIHMHAPEEGLRMLGSAMDKAADARTKLARLLATKGITHEIPLPDISTKEKAQKAIGLNMQQINAEKQDFLKTVVPQWEDQARKNGLLSQ
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: YAF2_HUMAN
Sequence: MGDKKSPTRPKRQPKPSSDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRKPRPVSQLVAQQVTQQFVPPTQSKKEKKDKVEKEKSEKETTSKKNSHKKTRPRLKNVDRSSAQHLEVTVGDLTVIITDFKEKTKSPPASSAASADQHSQSGSSSDNTERGMSRSSSPRGEASSLNGESH
What is the function of this protein?
Binds to MYC and inhibits MYC-mediated transactivation.  Also binds to MYCN and enhances MYCN-dependent transcriptional activation.  Increases calpain 2-mediated proteolysis of YY1 in vitro.  Component of the E2F6. com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.
What are the official names of this protein?
YY1-associated factor 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL28_CAMC5
Sequence: MSRRCAITGKGPMVGNNVSHANNKTKRRFLPNLRTIRVTLEDGTTRKIKVAASTLRTMKKQSN
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: DNAK_NITWN
Sequence: MGKVIGIDLGTTNSCVAVMDGKTPKVIENAEGMRTTPSIVAFSDDGERLVGQPAKRQAVTNPERTIFAVKRLIGRRYDDPTVEKDKQLVPYKIAKAGNGDAWVEADGKTYSPSQISAFTLQKMKETAEAHLGQKVDQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKSKAGTIAVYDLGGGTFDVSVLEIGDGVFEVKSTNGDTFLGGEDFDMRLVNYLADEFQKEQGINLRNDKLALQRLKEAAEKAKIELSSTTQTEINLPFITADQSGPKHLTMKLTRAKFEALVDDLVQKTIEPCRKALKDAGLTAGEIGEVVLVGGMTRMPKVQEVVKQLFGKEPHKGVNPDEVVAIGAAIQAGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRIIDRNTTIPTKKSQVFSTAEDNQNAVTIRVFQGEREMAADNKILGQFDLMGIPPAPRGMPQIEVTFDIDANGIVNVSAKDKATGKEQQIRIQASGGLSEADIEKMVKDAEANAAEDKKRREAVDAKNQADSLVHSTEKALTEHGSKIEESERRAIEDAVSDLKEALKGDDAEAIKAKTNTLAQASMKLGEAMYKQQAEADAAKDAAKDDVVDAEFTEVDDDKKSA
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: UVRC_STAAR
Sequence: MEDYKKRIKNKLNVVPMEPGCYLMKDRNDQVIYVGKAKKLRNRLRSYFTGAHDAKTTRLVGEIRRFEFIVTSSETESLLLELNLIKQYQPRYNILLKDDKSYPFIKITKEKYPRLLVTRTVKQGTGKYFGPYPNAYSAQETKKLLDRIYPYRKCDKMPDKLCLYYHIGQCLGPCVYDVDLSKYAQMTKEITDFLNGEDKTILKSLEERMLTASESLDFERAKEYRDLIQHIQNLTNKQKIMSSDKTIRDVFGYSVDKGWMCIQVFFIRQGNMIKRDTTMIPLQQTEEEEFYTFIGQFYSLNQHILPKEVHVPRNLDKEMIQSVVDTKIVQPARGPKKDMVDLAAHNAKVSLNNKFELISRDESRTIKAIEELGTQMGIQTPIRIEAFDNSNIQGVDPVSAMVTFVDGKPDKKNYRKYKIKTVKGPDDYKSMREVVRRRYSRVLNEGLPLPDLIIVDGGKGHMNGVIDVLQNELGLDIPVAGLQKNDKHQTSELLYGASAEIVPLKKNSQAFYLLHRIQDEVHRFAITFHRQTRQKTGLKSILDDIDGIGSKRKTLLLRSFGSIKKMKEATLEDFKNIGIPENVAKNLHEQLHK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_LEGPC
Sequence: MSTIQLEAQSRTDMGKGASRRLRRLENKVPAVIYGGSKKPMAIHFSHNKVIKALETESIYSSVFDITVDGKVEHVILKALQRHPYKPIVLHMDLQRVSSKDILVKLVPVHFINEEQSPGIKAGGIVQHTMTQVEIRCQAKDLPEFIEVDMSKVGMDDVVHLSDLKLPKGVQLTVDVTDGSHDAPVVSIHAAKVSSTELEETPEVPASAVPTTDQGESAE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: DLDH_CHATD
Sequence: MLSQRLIGRTAVKSAFRPSGLPTVVNASRWRRGYATEADRDLVIIGGGVAGYVAAIKAGQEGMKVTCIEKRGTLGGTCLNVGCIPSKSLLNNSHLYHTILHDTKHRGIEVGDVKLNLGQLMKAKEQSVSGLTKGIEFLFKKNGVEYLKGTGSFEDPHTVKVELNDGGETRVTGKNILIATGSEVTPFPGLEIDEKTIISSTGALSLDHVPKKFLVIGGGIIGLEMASVWSRLGSEVTVVEYLDQIGGPGMDTEISKNIQKILKKQGINFKTGTKVLNGEKTGDGVKINVEAAKGGKPETLEADVVLVAIGRRPYTKGLGLEKIGIELDERGRVIIDQEYRTKIPHIRCVGDATFGPMLAHKAEEEAVAVVEYIKKGYGHVNYGCIPAVMYTFPEVAWVGQSEQDLKKAGIPYRVGTFPFSANSRAKTNLDTEGFVKMLADPETDRLLGIHIIGPNAGEMIAEGTLALEYGASSEDIARTCHAHPTLAEAFKEAAMATYSKAIHF
What is the function of this protein?
Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes (By similarity).  This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine (By similarity).  The 10-megadalton pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) and catalyzes the overall oxidative decarboxylation of pyruvate to form acetyl-CoA and CO(2) (PubMed:33567276, PubMed:34836937).  Within the complex, pyruvate and thiamine pyrophosphate (TPP or vitamin B1) are bound by pyruvate dehydrogenase E1 subunits alpha and beta and pyruvate is decarboxylated leading to the 2-carbon hydrohyethyl bound to TPP.  The E2 component contains covalently-bound lipoyl cofactors and transfers the hydroxyethyl group from TPP to an oxidized form of covalently bound lipoamide, and the resulting acetyl group is then transferred to free coenzyme A to form acetyl-CoA and reduced dihydrolipoamide-E2.  Finally, the flavoprotein dihydrolipoamide dehydrogenase (E3) re-oxidizes the lipoyl group of dihydrolipoamide-E2 to form lipoamide-E2 and NADH.  A fourth subunit, E3BP, is responsible for tethering E3 in proximity to the core, forming the entire metabolon (Probable).
What are the official names of this protein?
Dihydrolipoamide dehydrogenase, Lipoamide dehydrogenase component of pyruvate dehydrogenase complex, Pyruvate dehydrogenase complex E3 component.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MAMO_MAGSA
Sequence: MIEVGETMGELPTNKIVFCERSWKTPVSILAFLIFVTFAWGIYLLDHYDEDDNFHGADDLSVGQFLVRNIAMPHVQRLYHTVPPAVVGVGGGGVNAGPVASGAIVGTNGYVITTLHSVSKLPEISVQVATTGGIRRFPAQVVKTIPGHDLALLKMQTTEKFLHFRMADVQTVVPGQQVFAFGRNMAGAPLVRQGLVQSADAPLAVGATQITHLLRSDAVYSWEQTGGPLVNAQGDLVGINIAATGPTGKVEGFTVPAQVIVSHLQDVVRFKKGSATAPGQPQTQTVAAGSTNWWSKARAVVGGPTAIPGMGMNVVQGNVVKGNVAPSIPSGMPFIDTDHVGGAKIGGYSVADIVGLVMLALAAGVTGGMMTMGGGVLQVAGMMVFFGYGMYLIRPVVFLTNVVVYGAASLRNDKAQLVQWDKVKPLIPWGIAGVILGYFIGNAIGDSVVGILLGLFALIMAGKAVMEILQPNAGEETAESISATEAEDEMDELMALADGTSRPKASGLALPEGHARSAVLGLPMGLFSGILGISGGVIEVPLQRYVGRISLQNAIANSSVLVFWASVAGSVVAFLHGSSTGLIHWEAPVTLALVMIPGAYVGGIIGARLMRVLPVRVLKGVYAATMAAIALKMLTSV
What is the function of this protein?
Plays 2 roles; promotes magnetite nucleation/formation and activates the MamE protease (Probable).  Despite its near conservation of a protease-like sequence, this is probably not a protease (PubMed:26981620) (Probable).  Required in conjunction with MamP for proteolysis of at least MamE, itself and MamP (PubMed:26981620).  May transport a solute that controls MamE's protease activity.  May place individual iron atoms into the magnetite lattice (Probable).
What are the official names of this protein?
Probable membrane transporter protein MamO.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
What are the subcellular locations of this protein?
Magnetosome membrane; Multi-pass membrane protein.
Protein: RL5_HAES1
Sequence: MAKLHDYYRDTVVNELKAKFNYSSVMQVPRIEKITLNMGVGEALTDKKLLDNAVADLAAISGQKPLVTKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLNTKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKSDEEGQALLAAFNFPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: GLYA_PELPD
Sequence: MSILSTLDPEVADAIRLEADRQEYNLELIASENFVSTAVLEAQGSVLTNKYAEGYPGKRYYGGCHNVDIVEALAIERAKQLFDAEHANVQPHSGSQANMAVYFSALKPGDTILGMNLSHGGHLTHGSPVNFSGRFFNVVPYGVSPETQTIDYAEVERLALEHKPKMIVVGASAYPRTIDFAAFRAIADKVGALVMVDMAHIAGLVAAGLHPSPIPHAEFVTTTTHKTLRGPRGGMILCQERFAKSINSQIFPGIQGGPLMHVIAAKAVAFKEALQPEFKQYQQQVVNNARTLAEELVKRGFKLTSGGTDNHLMLLDFSGTEITGKAAEEALDKAGITANKNTVPFETRSPFVTSGIRIGTPAATTHGLKEAEMVLVAGFIADAVANIGSDETLAAIKLQVNQLMKKFPLYAKG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIER2_HUMAN
Sequence: MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDELLALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSASSDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKIYENEDQLLWDPSVLPEREVEEFLYRAVKRRWHEMAGPQLPEGEAVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLGRRKYVPSGTTDADQDLDGSDPDGPGRPRPEQDTLTGMRTDPLSVDGTAGGLDEPGVASDGLPSSEPGPCSFQQLDESPAVPLSHRPPALADPASYQPAVTAPEPDASPRLAVDFALPKELPLISSHVDLSGDPEETVAPAQVALSVTEFGLIGIGDVNPFLAAHPTCPAPGLHSEPLSHCNVMTC
What is the function of this protein?
Transcriptional repressor.
What are the official names of this protein?
Mesoderm induction early response protein 2, Mi-er2.
What are the subcellular locations of this protein?
Nucleus.