PharMolix/UniProtQA huggingface dataset:
Protein: NU5C_CRYJA
Sequence: MEFIYKYAWIVPFLPLSASVPIGLGSLFFPGATKSVRRTWALISIFLLSVAMFLSFNLFLQQITGGPIYRYFWSWVINNKFSLELGYLIDPLTSIMLVLVTTVGTMVMIYSDNYMSHDKTYVRFFAYLNFFNASMLGLVISPNLLQIYIFWELVGMCSYLLIGFWFTRPSAANACQKAFITNRAGDFGLLLGILGFYWVTGSFEFQYLSEKLNELTAIDGVGSFFVTSCAFLLFLGPVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGIFLVARLFPLFKALPLIMYLISWIGGITALLGATMALAQKDLKRGLAYSTMSQLGYMMLALGIDSYRIALFHLITHAYSKALLFLGSGSVIHSMEPIVGYCPRKSQNMALMGGLRKYMPITGITFLLGTLSLSGIPPFACFWSKDQILSDSKLYSPIFGGITWFTAGLTAFYMFRMYLLTFEGDFRVNLVNSYNNHITLYSTSMWGEEESRILNRTRADSMSNQIIGRNNSFSKEAFQISNKMEGLYKKNRGLVVTYPFFYKGSFAYPKESGKAMLFPLVVLGIFTLFVGLIGVPFFRSGMRYDILSQWFASSTAPFDKKHPENWSEFFIDAIPSVGIAFLGILIACILYRPIYFLSQDVYHKTNPHMKIIMDQSINIIYNWSFYQAYIDIYYDIILIKGIRGLAETSHSFDQWAIDGIPNGVGFLGLFVGEGMRCLGGGRISSYIFFSLFCVLISILIYYYSFSFYP
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: FABV_RUMCH
Sequence: MIVTPKFRGFICTTSHPVGCEYSVMNQVEYIKNQKKINGAKKVLVIGASTGYGLASRITAAFGCGAATIGIFFERPGSKNKTASAGWYNSAAFEKMAKEEGLYAKSINGDAFSNEIKQKTIDLIKKDLGKVDMVVYSLASPRRTHPVTGEVFNSVIKPIREAYTSKTVDFHTQLVSETTIEPASDDEIRQTIAVMGGEDWSMWMDALKKADVLEDNVMTLAYSYVGPEVTHSVYREGTIGKAKDDLEATAIKINENLRTIGGKAYVSINKAVVTQASAAIPVISLYVSALFKVMKEKNIHEGCIEQMYRMFNDRLYSGDLKLDSKGRICMDDLEMRPEVQNEVTKLWNEANNDNVKDITDIEGYRREFFRLFGFEFEDVDYNADVDIEVNIEGLY
What is the function of this protein?
Involved in the fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).
What are the official names of this protein?
Trans-2-enoyl-CoA reductase [NADH], TER.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: RSMJ_ECO57
Sequence: MKICLIDETGTGDGALSVLAARWGLEHDEDNLMALVLTPEHLELRKRDEPKLGGIFVDFVGGAMAHRRKFGGGRGEAVAKAVGIKGDYLPDVVDATAGLGRDAFVLASVGCRVRMLERNPVVAALLDDGLARGYADAEIGGWLQERLQLIHASSLTALTDITPRPQVVYLDPMFPHKQKSALVKKEMRVFQSLVGPDLDADGLLEPARLLATKRVVVKRPDYAPPLANVATPNAVVTKGHRFDIYAGTPV
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSM6_USTMA
Sequence: MSAAAQQPNAKAGSPNDFLKGVIGKNVNVRLNSGIDYRGVLSCLDGYMNIALEQTVEYVDGIKKNSYGDAFIRGNNVMYITALEK
What is the function of this protein?
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates.  Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.  Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs.  LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6. U5 tri-snRNP, and free U6 snRNP).  It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes.  LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm6.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYL_PSYIN
Sequence: MQELYNPKEIEKKFQTNWDENQSFKATEDPSKEKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENAAIKNNTAPAGWTYENIAYMKTQLKQLGFGYDWSRELATCQPEYYRWEQWFFTKLVEKDLVYKKMATVNWDPVDQTVLANEQVIDGRGWRSGALVEQKEIPQWFIKITAYAQELLDDLDKLDEWPEQVRTMQRNWIGRSEGVEMDFKVSGKEESFSVYTTRPDTVMGVTYVAVAAQHPLALEAAKNNPTLAAFCKKCKNVKLAEAEIATMAKEGVDTGFKAIHPISGLEVPIWTANFVLMGYGSGAVMSVPAHDQRDYEFAKKYDLTIKAVIKPANTDLDISVEAYTEKGVCFDSGEFDGLDFSAAFDAVETKLVAENKGKRQVNFRLRDWGVSRQRYWGTPIPMLNLEDGSVVPVPENELPVILPEDVQMNGIVSPIKADPDWAKTTYNGQPATHETDTFDTFMESSWYYARYCSPQSDDAMLDPEKANYWLPVDQYIGGIEHAILHLLYSRFFHKLLRDFGLVDCDEPYKKLLTQGMVLADAYYYEDAKGGKVWIAPTDVETETDEKGKVISAATKDGQTVIYDGMSKMSKSKNNGVDPQVMIDKYGADSVRLFMMFAAPADQTLEWSDSALEGSLRFLKRLWKIAFDHLALGAVADLDLKSHTEAQKTLRRELHKTIAKVTDDIGRRQTFNTAIASVMELMNKLTKTATKTEQDRAILQEALLAITKLLAPITPHICAELFEVLGQTEEILNAPWPTVDESALVEDSKLIVVQVNGKLRAKLTVAADAQQETVQAIAMENENVSKFTDGKTIRKIIFVPGKLLNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_BORHD
Sequence: MAVITMKSLLEAGVHFGHQVKRLDPRMKRFIFSERNEIHILDLQKTLQGIKDSYELVQSVIKSGKKVLFVGTKKQASEIIEQEAKRSDMPYVNNRWLGGMLSNFNTIKKSVQKLKKLEKMEIDGTFEMISKKEVSQLNREKLKLSKNLTGIKDMEELPGAVFIIDPKREQIVINEARKLGIPIISVVDTNCNPDVIDCPIPGNDDAIRSVALFTKIISDAILESDKEVGIQIVENLNEEDLMSEIEVKNEKKEL
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SYFB_STRCO
Sequence: MRVPLSWLREYVDLPATETGRDVQAKLISAGLEVETVEHLGADLKGPLVVGQVLTIEELEGFKKPIRFCTVNVGQANGTGEPQEIVCGARNFAVGDKVVVVLPGATLPGGFSISARKTYGKTSHGMICSSDELGMGDDGTHGIIVLPPETEVGKDAIELLELVDEVLDIAVTANRGDCLSIRGVARETAIAYGLPLRDPALLDVPGPNAYGYPVKIADPTGCDRFTARTVTGLSAEARSPIWLQRRLQKVGMRPISLAVDVTNYVMMELGQPLHAYDRSLVQGTIGVRRAQEGEKIVTLDGTERKLHAEDLVITDDRGPIGLAGVMGGANTEIADHDAAENGGNATSDVVIEAAHFDQVSIARTARRHKLSSEASRRFERGVDPQAAAAAAQRTVDLLVLLAGGTAEAGVTEISAPSAPHTISVPADHPDKVAGVEYGRETVVRRLQEVGCDVYGQDELIVTVPSWRPDLDDINDLAEEVIRLEGYENLPSTLPRPPAGRGLTSRQRLHRRVGRALAGAGYVEALNYPFVGEQVFDQLGLDADDPARRVVRLVNPLSDEEPALRTSLLPGLLAALRRNDGRGAHDLALFETGLVFHPRDEQRVAADLPVDRRPSEDDLAALDAALPDQPRHVAVVLAGAREQAGWWGKGRPADWADAVESARTVAREARAELGVRKGQYGPWHPGRCAELFVTVDGEERVVGHAGELHPRVLKTLGLPARTCAMELDLDALERVGDDIPQAPGISTFPVATQDVALVVDAFVPASEVEAALREGAGELLESIRLFDVYDNAEQLGEGRKSLAYALRFRAKDRTLTVDEASAARDAAVALAGERVGAVLRS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUSD1_MOUSE
Sequence: MEPGSMENLSIVYQSSDFLVVNKHWDLRIDSKTWRETLTLQKQLRHHFPELADPDTCYGFRFCHQLDFSTSGALCVALNKAAAGSAYKCFKERRVTKAYLALVRGHVQESQVTINYAIGRNSTEGRTHTMCIEGTHGCENPKPSLTELLVLEHGLYAGDPVSKVLLKPLTGRTHQLRVHCSALGHPIVGDLTYGQAEDQEDQPFRMMLHAFYLRIPTQAERVEACTPDPFLPALDACWSPSTCVQPLEQLIQALRTDPDPDPMSGGPRPCSPSTPQPRPGRPPPETEAQRASCLQWLSEWTLEPDN
What are the official names of this protein?
RNA pseudouridylate synthase domain-containing protein 1, Ribosomal large subunit pseudouridine synthase C-like protein.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: SPRT_PSEA8
Sequence: MPEHLNARVEACYRQAEHFFQRSFPRPTVSFRLRGQKAGVAHLDENLLRFNPQLYRENREHFLEQTVAHEVAHLIAHQLFGPRIRPHGEEWQLIMRGIYGLPPDRCHTYAVKRRATTRYLYRCHCPEHNDFPFSPQRHTLVAKGRRYYCRRCKATLVFTGEVLRE
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESYT3_HUMAN
Sequence: MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSITWLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEWANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTNTCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTVFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECALGMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALKKGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKRLAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQPRS
What is the function of this protein?
Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).  Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
What are the official names of this protein?
Extended synaptotagmin-3, E-Syt3, Chr3Syt.
What is the protein family that this protein belongs to?
Belongs to the extended synaptotagmin family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:30220461). Recruited to the cell membrane via the third C2 domain.
Protein: DOP1_HUMAN
Sequence: MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKKLTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMSVKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSAFYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSVLVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGAIIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISLLDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIKTANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLLDIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKILSKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSESGFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQGTATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSKWDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLETDCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQPLSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQLHNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLFIMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYWNKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLSLLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMPKESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDSIQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKSRQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQTSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSRTLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIPVDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTELAKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFSEDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPHQPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVVSVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTTQYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTINLGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLVELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDSWASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGAIAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTLLSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGYQYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSSLNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQVFLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYTGGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRRQGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLEGMIKT
What is the function of this protein?
May be involved in protein traffic between late Golgi and early endosomes.
What are the official names of this protein?
Protein dopey-1.
What is the protein family that this protein belongs to?
Belongs to the dopey family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein.
Protein: VIF_HV1SE
Sequence: MENRWQVMIVWQVDRMRIRTWHSLVKHHMYVSKKARGWFYRPHYASRHPRVSSEVHIPLGDATLVVTTYWGLHTGEKDWQLGHGVSIEWRQRRYRTQVEPDLADHLIHLHYFDCFSDSAIRKAILGQIVSPRCEYQAGHNQVGSLQYLALKVLVTSKRSRPPLPSVTELAEDRWNKPQKTRGHRENPTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: RLMN_AGRRK
Sequence: MSAIDVMTPSKLKPMPVSQPVELSPKPSLIGLTREEMGAALKEKGVADKQVKMRVSQLWNWIYVRGVSDFDAMANVSKDMREMLKAHFTIARPEIVEEQVSNDGTRKWLLRFPPRGAGRPVEVETVYIPEEGRGTLCVSSQVGCSLTCSFCHTGTQRLVRNLTAEEILSQLLLARDRLGDFPDREAPQGTIMPAEGRKVSNMVMMGMGEPLYNFESVKTALLIASDGDGLSLSKRRITLSTSGVVPEIYRTGDEIGVMLAISLHAVRDDLRDMLVPINKKYPLKELMDACRAYPGLSNARRITFEYVMLKGVNDSLEDAKGLIQLLKGIPSKINLIPFNPWPGTNYQCSDWEQIEKFADFINAAGYASPIRTPRGRDILAACGQLKSDSERMRKTERLAFEAMMIANHGED
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THRC_CORGL
Sequence: MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALAAEVISLFVDDIPVEDIKAITARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDMAMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRGREGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYYVSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTHETSSPSMDISRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDANFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHTADGVHVARQWRDEVNTPIIVLETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIANTSVK
What is the function of this protein?
Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
What are the official names of this protein?
Threonine synthase, TS.
What is the protein family that this protein belongs to?
Belongs to the threonine synthase family.
Protein: PVK2_BLADU
Sequence: GSSGLISMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, BlaDu-PVK-2, PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS20_AFIC5
Sequence: MANTTSAKKATRKIARRTAVNKSRRTQMRGSVRLVEAAILKGDRAAAVEAMKQAEPQLMRAAQRSIIHKNTASRKVSRLVAQIAKLAQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: WDR12_CAEBR
Sequence: MDLSESMEVDNGTTSENLKHVQITFFSKDKDLPEIPDAVFDVPTVAECDDLNLLLNKTIQATDDAWKEKKFEFLVGETFLRTSLAEFIEEYEVETETILKIECIIGIEAPKPLHDIQAPDWVSSVQVANGHTKSTNLFSIFSTTYGGDIVIVDRKGKETKLSVNSANRILKCSGIVRTTKKVQLEGTEFIVGGENQLLTLYEIEKGALVEKIVFRGHERAVECVSVNSDATRAISGSVDTNLKVWNLDPSDEATIYEKEEEESSAKKKRKKDTRTKVPMVTIGGHRDKVSSVVWCPWKSGHAFSCSWDHTVVQWDLELAGEVSRIKGPKSFTSIDIHPTSNLLISSCTDAIPRLYDPKNRDGAMVKQSFIGHQNGWVESVKWNPVDENQFVSVSTDKTAKMWDVRSSKSSLFDIHGHEDRILCAAWNEGLIATGSADCSIKIFETS
What is the function of this protein?
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein WDR12 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR12/YTM1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: CTF1_RAT
Sequence: MSQREGSLEDHQTDSSFSFLPHLEAKIRQTHNLARLLTKYADQLLEEYVQQQGEPFGLPGFSPPRLPLAGLSGPAPSHAGLPVSERLRQDAAALSALPALLDAVRRRQAELNPRAPRLLRSLEDAARQVRALGAAVETVLAALGAAARGPVPEPVATSALFTSNSAAGVFSAKVLGLHVCGLYGEWVSRTEGDLGQLVPGGVA
What is the function of this protein?
Induces cardiac myocyte hypertrophy in vitro.  Binds to and activates the ILST/gp130 receptor.
What are the official names of this protein?
Cardiotrophin-1, CT-1.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRHO_BACHK
Sequence: MATTKPYRVLLYYMYTTIENPEEFAAEHLEFCNSLELKGRILVAKEGINGTCSGTVEQTEKYMEAMNNDPRFDGIVFKIDEADGHAFKKMHVRPRPELVTLRLEDDINPHEITGKYLEPKDFYEAMKQEDTVIIDARNDYEFDLGHFKGAIKPDIESFRELPDWIRENKEVLEGKKILTYCTGGIRCEKFSGWLVREGYEDVSQLHGGIVTYGKDPEVQGELWDGQCYVFDERIAVPVNQKEHVIVGKDHFTGEPCERYVNCANPECNKKILCSEENEAKYLRACSHECRVSPRNRYVIQHELTEEQVAAALEQIEAGK
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: PROQ_SALHS
Sequence: MENQPKLNSSKEVIAFLAERFPHCFSAEGEARPLKIGIFQDLVERVGGEMNLSKTQLRSALRLYTSSWRYLYGVKPGATRVDLDGNPCGELEEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAAAAGEKEDAPRRERKPRPVARRKEGAERKPRADKPTTKAPRAPREEKHTPVSDISVLTVGQSLKVKAGNNAMDATVLEITKDGVRVQLNSGMSLIVRAEHLVF
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.  May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBB_SHEEP
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRMRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC
What is the function of this protein?
Exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
What are the official names of this protein?
Polyubiquitin-B.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. Mitochondrion outer membrane; Peripheral membrane protein.
Protein: HEM6_RICBR
Sequence: MNKKNREVTSSWFTNLRDLVCAEFEKIEEEYAKAKGLKPGKFVRSSWERDGGGGGVMSVMKGKVFEKVGVNISTVFGEFSKAFRAEIPGAELDGKFFATGISLVAHLKSPLIPAMHFNTRYIETSKNWFGGGGDLTPFYPEEDETAKFHAAFKEACDKYDSGYYPKFKKQCDEYFYLKHRKEPRGVGGIFYDYLNSGNFEQDFSFTQDVGKALLSVYPEIVRNKLFLPWTDEQKEYQLIRRGRYVEFNLLYDRGTKFGLMTDGNVEAILMSLPPEVKWA
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_BACFN
Sequence: MKTTLIVVGRTVEQHYITAINDYIERTKHFISFDMEVIPELKNTKSLTPEQQKEKEGELIAKALQPGDVVVLLDEHGKEMRSVEFARWMEKKLVNVNKRLVFIIGGPYGFSQKVYDAAHEKISMSKMTFSHQMIRLIFVEQIYRAMTILNGGPYHHE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.