PharMolix/UniProtQA huggingface dataset:
Protein: TM131_HUMAN
Sequence: MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAITVHFKPITLKASESKYTKVASISFDASKAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIRDSPADPVERPIYLTNTFSFAILIHDVLLPEEAKTMFKVHNFSKPVLILPNESGYIFTLLFMPSTSSMHIDNNILLITNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGVLSATEASNILFAIINSNPIELAIKSWHIIGDGLSIELVAVERGNRTTIISSLPEFEKSSLSDQSSVTLASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHVVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNKEDLEPGKKSKIANIYFDPGLQCGDHCYVGLPFLSKSEPKVQPGVAMQEDMWDADWDLHQSLFKGWTGIKENSGHRLSAIFEVNTDLQKNIISKITAELSWPSILSSPRHLKFPLTNTNCSSEEEITLENPADVPVYVQFIPLALYSNPSVFVDKLVSRFNLSKVAKIDLRTLEFQVFRNSAHPLQSSTGFMEGLSRHLILNLILKPGEKKSVKVKFTPVHNRTVSSLIIVRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCTDSLKLREPNFTLKRTFKVENTGQLQIHIETIEISGYSCEGYGFKVVNCQEFTLSANASRDIIILFTPDFTASRVIRELKFITTSGSEFVFILNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAGGSSSRPSAGSHKQCGPSVHPHSSHSNRNSADVENVRAKNSSSTSSRTSAQAASSQSANKTSPLVLDSNTVTQGHTAGRKSKGAKQSQHGSQHHAHSPLEQHPQPPLPPPVPQPQEPQPERLSPAPLAHPSHPERASSARHSSEDSDITSLIEAMDKDFDHHDSPALEVFTEQPPSPLPKSKGKGKPLQRKVKPPKKQEEKEKKGKGKPQEDELKDSLADDDSSSTTTETSNPDTEPLLKEDTEKQKGKQAMPEKHESEMSQVKQKSKKLLNIKKEIPTDVKPSSLELPYTPPLESKQRRNLPSKIPLPTAMTSGSKSRNAQKTKGTSKLVDNRPPALAKFLPNSQELGNTSSSEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQRQTSPTPASPSPPAAPCPFVARGSYSSIVNSSSSSDPKIKQPNGSKHKLTKAASLPGKNGNPTFAAVTAGYDKSPGGNGFAKVSSNKTGFSSSLGISHAPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSAFGNSFNLTGEVFSKLGLSRSCNQASQRSWNEFNSGPSYLWESPATDPSPSWPASSGSPTHTATSVLGNTSGLWSTTPFSSSIWSSNLSSALPFTTPANTLASIGLMGTENSPAPHAPSTSSPADDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN
What is the function of this protein?
May play a role in the immune response to viral infection.
What are the official names of this protein?
Transmembrane protein 131, Protein RW1.
What is the protein family that this protein belongs to?
Belongs to the TMEM131 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CY24B_HUMAN
Sequence: MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF
What is the function of this protein?
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide.  It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior.  Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes.  It participates in the regulation of cellular pH and is blocked by zinc.
What are the official names of this protein?
Cytochrome b-245 heavy chain, CGD91-phox, Cytochrome b(558) subunit beta, Cytochrome b558 subunit beta, Heme-binding membrane glycoprotein gp91phox, NADPH oxidase 2, Neutrophil cytochrome b 91 kDa polypeptide, Superoxide-generating NADPH oxidase heavy chain subunit, gp91-1, gp91-phox, p22 phagocyte B-cytochrome.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=As unassembled monomer may localize to the endoplasmic reticulum.
Protein: GSH1_PSEPW
Sequence: MSDLLNRRLSLLGANLPLLKQCLHGIERECLRVTDEGRLAQTPHPESLGSALTNEQITTDYSESLLEFITPALPDPAQVLESLEQTHRFVYSKLGDELLWSPSMPCTLPAEEDIPIAEYGASNIGKLKHVYRKGLALRYGRTMQCIAGIHYNFSLPEALWPLLRASDGNEQSDRDYQSAAYIALIRNFRRYSWLLMYLFGASPALDKGFLRGRPHQLEELDAETLYLPYATSLRMSDLGYQSNAQAGLTPCYNNLASYTDSLRKAVGTPYPPYVEIGTHVDGEWVQLNTNILQIENEYYSNIRPKRVTYTGERPIQALTSRGVQYVEVRCLDINPFLPVGIDLTEARFLDAFLLFCALEDSPLLDNGECGQCTDNFLTVVKEGRRPGLELRRDGHPIELKAWASDLLGRIGQLAELLDRAQGGDEHAKALAAQQAKVDDASLTPSAQVLARMGEHEESFIQFSLRQSRLHAETFREQPLPTERQQAYETLARNSLAEQSRLEQEEVGDFDLFVGAYQASILAISN
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: O165_CONCL
Sequence: MKLTCVLIVAVLVLTACQFTAAIDSRDGQDNPALRSTGGMQRKSQTQRLSKKCIPDHHGCGLLHHSRYCCNGTCFFVCIP
What are the official names of this protein?
Conotoxin Cl6.5.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RIMM_XANCP
Sequence: MKPTERRILLGRIVGAFGVKGELKLESWTEPRSAIFRYQPWIVRTPSGQESVLSGVRGRDQGKNLIAVFPDITDRDTVEAMHGTEIYVARSALPPPKPDEYYWVDLEGLQVETVEGVKLGTVSHLFSTGSNDVVVVRGDRERMIPFVLPEYVKSVDFEANLIVVDWDPDF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGR6_CYCAE
Sequence: MPGSANWTADRFYIPDTLANWPWPRAINPAYEECKAASAAWCEKYGAFSARAQKAFNLCDFNLLASLAYAGLPADVNRVGCDLMNLFFVVDEHTDAMDARSVQDWVDIVVDALHHPHTPRPAGEPKVGEIARTFWENGIKCMGPTAQRRFVETFTTYLQSVVTQAQDRDKHLFRDVDSYMEVRRDTIGAKPSFALLEHDMELPDDVFYHPLLEKLREWAIDMLILGNDLCSYNVEQSRGDDGHNIIRLAMLQENTNVHGALRFVSKMHDDLAEKFLSNYQGMPSFTPQIDAWVTRYIDGLGNWVRANDSWSFESWRYFKGDVLRVQAERWVELLPPAPKDELTSSIPPESRWIKPAVEPSRARPNNVGIVALDTYTPTSEDDFQTLAVKTVSSLLSKYNINPVSVGRLDICIERAADPYIIYALRDAFASAGNTDVEAIVSSSKSVVGLFNAINWVESSSWDGRYAIVFAGDLSSGVSAALVGPDAPIVVEPTRGTYLGDPIASTDEAQGSYIDSLFQSYSHYRKKHPQFSKTSGAPNGAHTPTTTNGSIKSNGFVSGDTNGHANGNGHVQTRSSTPSSSSSSTSSPSFDYMILHDRHGKIPTGAGSIYLGLASLITDIAPETLAGKSIGVFGFANSTSTFFGIRVAGDCSVICKQLQA
What is the function of this protein?
Terpene cyclase that catalyzes the cyclization of farnesyl diphosphate (FPP) to delta(6)-protoilludene.
What are the official names of this protein?
Delta(6)-protoilludene synthase, Terpene cyclase Agr6.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: HR2_ARATH
Sequence: MPLTEIIAGAALGLALQILHEAIQRAKDRSLTTSCILDRLDSTILRITPLMAKVEKLNKESDESLRKVFEDLKHLLEKAVVLVEAYAELKRRNLLGKYRYKRRIKELEGSLKWMVDVDVKVNQWADIKDLMAKMSEMNTKLEKIMGQPIDCIISEDNTNMDIVERVDPSLEAKAGCSNSDSKPKIDIHLRWSKQSKDHGIRFVLN
What is the function of this protein?
Probable disease resistance (R) protein.
What are the official names of this protein?
RPW8-like protein 2, AtHR2.
What is the protein family that this protein belongs to?
Belongs to the plant RPW8 protein family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NUOC_MYCPA
Sequence: MSSPDQDPREAIAQGDDEVIDVRRGMFGAAGTGDTSGYGRLVRTVTLPGSSPRPYGSYFDDVVDTLTESLQSNGIEFHQAIEKVVVYRDELTLHVDRAALPHVAQHLRDDPRLRFEMCLGVSGVHYPHETGRELHAVYPLQSITHNRRVRLEVAVPDEDPHIPSLYRIYPTTDWHERETYDFFGIVFDGHPSLTRIEMPDDWHGHPQRKDYPLGGIPVEYKGAQIPPPDERRAYN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SMG9_CAEBR
Sequence: MKKVEILKTPVIQQRPVAPSRTSSPPVTAPRIAIKPRPPPASGNSGIPENNGPISPPDSSVSKSSGMKESVRFLNDIGEITDSISDLLTNSPNFNVISAIGPQGAGKSTILSMLAGNNSRQMYREYVFRPVSREANEQSRHQTTQIDIYVTNHQIFLDCQPMHSFSIMEGLPKLRGGRLDEATAMSDTLRLTAFLLFISHTVLVISETHFDKTIIDTIRTSEQIRPWLHQFRPKLSIERMTNLVFIKTKASSIDTAPSVIRERAQLLRLAFRDSKWLKISKEPFKCLLVLEEIRVKREHLYEGEDEIDETMLNEFDEHIAQLRVMLQRNRDDFTVETAAMDEKKWLEMCQEVIRDKTFHRILKEFHRSDRDRSSIYAENGDR
What is the function of this protein?
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes (By similarity).
What are the official names of this protein?
Nonsense-mediated mRNA decay factor SMG9, Suppressor with morphogenetic effect on genitalia protein 9.
What is the protein family that this protein belongs to?
Belongs to the SMG9 family.
Protein: MNMG_XANCP
Sequence: MSDSFYRYDVIVIGGGHAGTEAALAAARAGARTLLLTHNIETVGAMSCNPAIGGIGKGHLVKEIDALGGAMAKAADLAGIQWRTLNASKGPAVRATRCQADRNLYRSAIRRIVEAQPNLTVFQAAVDDLIIHNGAAEGDSVRGVITQTGLRFEATAVVLTAGTFLAGKIHVGETQYAAGRMGDPPATTLAARLRERPFAIDRLKTGTPPRIDGRTLDYTMMDEQPGDDPLPVMSFMGQVSDHPTQVSCWITHTTEQTHDIIRGALHRSPLYSGQIEGIGPRYCPSIEDKVVRFADKTSHQIFVEPEGLDVTEIYPNGISTSLPFDVQLALVRSIRGFAQAHITRPGYAIEYDFFDPRGLKASLETKAVGGLFFAGQINGTTGYEEAAAQGLLAGLNAARQAQALPAWSPRRDEAYLGVLVDDLITHGTTEPYRMFTSRAEYRLQLREDNADLRLTGVGRAMGLVDDARWARFSSKQEAVQRETARLSALWATPGNALGREVVDTLGVPMSRETNVLDLIKRPELSYAALMRVPTLGPGVDDAQVAEQVEIGVKYAGYLNRQRDEIARQQRHETTPIPEGFDYAGVRGLSMEVQQKLERVRPQSIGQAQRIPGMTPAAISLLLVHLERARRSQVA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_MAGSA
Sequence: MARVTVEDCVLKVPNRFELVLIAGQRARDISAGAKLTVERDNDKNPVVALREIADDTVPLDALQNALIQNLQKHVEVDEPEEDEMEGFIADRDLAFENVANEDEMIEDGMSINDTGADFDVDSGDE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: DAPB_LIMF3
Sequence: MTKVLIAGFAGAMGQQAVTLVKSLPGFELSAVVGHHLTDLDPTSYGLENSTTVYADREQVETGAADIWLDFTVPAAVFENVSYALRHGMAPVVGTTGLSDEQVEELQQLAKQNGLGGLIAPNFGMSAVLLMKFAKEAAAYFPEVEIIEMHHEDKKDAPSGTALATAKLISENRPAHETAPDSTESLPGARGGDYQGIKLHAVRLPGYVAHEQVLFGGSGEALTIRQDSFDRSSFMSGVKVGLEKVGTLTELVVGLENVL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AB17A_HUMAN
Sequence: MNGLSLSELCCLFCCPPCPGRIAAKLAFLPPEATYSLVPEPEPGPGGAGAAPLGTLRASSGAPGRWKLHLTERADFQYSQRELDTIEVFPTKSARGNRVSCMYVRCVPGARYTVLFSHGNAVDLGQMSSFYIGLGSRLHCNIFSYDYSGYGASSGRPSERNLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRVAFPDTKKTYCFDAFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDIELYSQYLERLRRFISQELPSQRA
What is the function of this protein?
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913).  Has depalmitoylating activity towards NRAS (PubMed:26701913).  Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913).  May have depalmitoylating activity towards MAP6 (By similarity).
What are the official names of this protein?
Alpha/beta hydrolase domain-containing protein 17A, Abhydrolase domain-containing protein 17A.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. ABHD17 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Endosome membrane; Lipid-anchor; Cytoplasmic side. Cell projection, dendritic spine. Postsynaptic density membrane.
Protein: LON1_MYXXA
Sequence: MFFGRDDKKEAQKRGLTVPLLPLRDIIVFPHMVVPLFVGREKSIAALKDAMAHKGPDDKAVILLAAQKKAKTNDPTPDDIFHFGTLGHVIQLLPLPDGTVKVLVEGVRRAKVKKFHPNDAFFMVEVEEVEEQTEKTVELEALVRSVHSVFEAFVKLNKRIPPEMLMQVASIDDPARLADTIVAHLSLKLNDKQALLETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEYYLNEQMQAIQKELGERDEFKNEIQEIEEKLKNKRMSKEATLKVKKELKKLRMMSPMSAEATVVRNYIDWIISLPWYDETQDRLDVTEAETVLNEDHYGLKKPKERILEYLAVQQLVKKLKGPVLCFVGPPGVGKTSLARSIARATGRKFVRLSLGGVRDEAEIRGHRRTYIGAMPGKLIQSLKKAGSNNPVFLLDEIDKMSTDFRGDPSAALLEVLDPEQNHTFNDHYLDLDYDLSKVMFICTANTMHNIPGPLQDRMEVIRIAGYTEPEKLSIARRYLIPKEQEANGLSDLKVDISDPALRTIIHRYTRESGVRSLEREIGGVFRKIARDVLKNGKRDIDVDRKMAMKFLGTPRYRYGMAEAEDQVGIVTGLAWTELGGEILTTEATIMPGKGKLIITGKLGEVMQESAQAAMSYVRSRAERFGIDRKVFENYDIHVHLPEGAIPKDGPSAGVTICTALVSALTRVLIRRDVAMTGEITLRGRVLPIGGLKEKTLAAHRAGIKTVLIPKANKKDLKDIPLKIRKQLRIVPVEFVDDVLREALVLEKPEEFGRKPTTDGGKLGGTTELPASPAVAPA
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease 1, ATP-dependent protease La 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_THET2
Sequence: MKYKRVLLKLSGEFLTRNGFGIEPEATQALAREIKAAYDTGVQLAIVIGAGNLWRGARQGVGMDRATADYIGMLATIMNALALQDALESLGVPTRVQTALTITQVAEPYIRRRALRHLEKERIVIFGGGTGNPFFSTDTAAALRALEVGAEVVLMAKNKVDGVYSDDPRKNPEAVRFDELTYLEVLNRGLQVMDTTAITLCMEAGLPIVVFDIFKPGALVGIIQGEKVGTLIH
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACEK_BURL3
Sequence: MNHFPKLLSSQIGFDVAQTMLENFDRHYRIFREAAVEAKTLYEHGDWHGLQRLARERITSYDDRVKECVEVLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGLATTLERIVTNFQLEPAFDDLPRDIGCVMQAIHDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRIINADRVLPFAVPIRHVRPGVLSLDTVLLRRDQLMIIFGFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPIARLDHALVRELEKEVPSLLEYEDGNLVIEHLYIERRMTPLNLYLQNGSDSDVEHGVKEYGNAVKELMKANIFPGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRVRDVFMKHHADFFDPALWQASKDKLIQGELPDFYPYDTALRFCTRYPARFGATDQNDGAGDAQRAA
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_SALNS
Sequence: MSNRKYFGTDGIRGRVGNAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSASFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDDVEEAIEAEMEKEITCVDSAELGKASRIVDAAGRYIEFCKGTFPNELSLNGLKVVVDCANGATYHIAPNVLRELGATVIAIGCEPNGVNINEEVGATDVRALQARVLAEKADLGIALDGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKLQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMVRNHMSLHDLCSGMKMFPQILVNVRYTAGSGDPLENEAVKAVTADVEATLGNRGRVLLRKSGTEPLIRVMVEGEDEAQVTAFAHRIADAVKAV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: APAG_BORPE
Sequence: MSNRERPVKPYDLTVSVTPRYVPEQSDPSQQQYVFAYTVRITNTGSHPAQVISRHWIITDGEERVQEVRGLGVVGQQPLLAPGETFEYTSGCPLPTPIGTMRGTYHCVGENGIPFEVPIAEFLLAMPRTLH
What are the official names of this protein?
Protein ApaG.
Protein: ADCF_DICDI
Sequence: MEIIKENNENDGENINNIPKKKSGSKRQLSFKKKWKASFKKNDFVNSHGINYNKSVGVGGNSGMPQRRNSIVAKPIGLTSYKINHNHNYQSQKLTWKYTSPTNSSLNLKNSDLKYLNNENKNISDNSNFDDGEEDDTDNKKNINNKNNNNNNPLTDIINIEEKIANTTTTTTNTTTINTETKNDIDTTISKLNNFYDNDETNNNIQNETDGNNNNSFSISNNLIIKEKNNNNNKNDNGDSDDDEDCKIIILDKPHIENLNDKNKQILSQPHTLTQPLTPTSNNTHKSTLFKKLELPPAPPSPPQPPVFQNLNNCDNIIQHQLENNCDAKNKSINIYNNEFDFKNNNNNIIENNENFEKNLNLLNNNNNFYHNNNLKKSKDNILKKSNNNINNINNININNNNNNNKKSKSKIKIFKKLLNNNIDRLNKNNMDNVLMKSQIIQINGAEIDDGNNYFNKNDQQHIEDNLMFLNETSQTNNATCEIDNLIDSIKINLSNGYFIAGQKVTGNLEISLNQDIKTSGLNLKWKVFEHVIINHYQSPQSPQKLNKKDKEKEKEKEKENDNDNENNNSESLIRDQSFELIDASSLKSFSNSSNCGSSLRNSQSINLNNYNFNNYKGGTLKKNSKIFNVLKNSSSITNFLKINPLTSSSSDFSLNSSSNYNLNLFNENRLIYKNQEKKTIYESGDSIFQTDDNGGIMNSGLHIIPFSFLLPSHLPSSFSDFTIDKETNEKILSAIIYKLSISFQDILYEEEDNDENNNNNFYNQHDDNEDNENIRNKKEYLKSLYELLKDYKIKKSFTVCEPSIIAAKVNEIPIRMEKKKSFLVNSGQISLKVALKRTIFFANEKIPINIKIENASSRSIDYILISIKKIQNISLSLIKKSKNNNEKQQQQIEKDNDEQQPNITDLTLSPSSSSFLSNSSNTSSSKNNNNNNNNLIFKKCTFKTSQRFNGVDAHCNFSDTILFDTNEIKGFNQTTNGTLIKCHYNIVIQCFVKRAFNVVCRIPILFGALPENNLTSIFNDEYQLNLLNM
What are the official names of this protein?
Arrestin domain-containing protein F.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
Protein: NHAB_EDWI9
Sequence: MTITYTQAFAKNFLGNAPGWYKIAILAFLIINPLVFSLSPFYAGWLLVIEFIFTLAMALKCYPLQPGGLLALEAVFIGMTSPEKIAHEVAANLEVLLLLIFMVAGIYFMKQLLLFVFTKLLLNIRSKIVLSLAFCLAAAFLSAFLDALTVIAVVISVAVGFYGIYHQVASGGGSNVALSDDSLLTDSAKRDALDQFRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIAKNADWHFVSFLLRMAPVTVPVFCCGILTCYLVERFSLFGYGAQLPDRVRQILLNFDRESTNSRSRQDKLRLMIQALVGVWLVSALAFHLAEVGLIGLSVIVLVTSLCGVTDEHLIGKAFQESLPFTALLTVFFSIVAVIIDQHLFTPVIQFVLQSPPDRQLTLFYLFNGLLSSISDNVFVGTVYIHEAKAALESGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTVVMTLVGLLCVIFTLEPATQLMSQWHLLTLPPAQDVLSSGL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MIR1_HHV8P
Sequence: MEDEDVPVCWICNEELGNERFRACGCTGELENVHRSCLSTWLTISRNTACQICGVVYNTRVVWRPLREMTLLPRLTYQEGLELIVFIFIMTLGAAGLAAATWVWLYIVGGHDPEIDHVAAAAYYVFFVFYQLFVVFGLGAFFHMMRHVGRAYAAVNTRVEVFPYRPRPTSPECAVEEIELQEILPRGDNQDEEGPAGAAPGDQNGPAGAAPGDQDGPADGAPVHRDSEESVDEAAGYKEAGEPTHNDGRDDNVEPTAVGCDCNNLGAERYRATYCGGYVGAQSGDGAYSVSCHNKAGPSSLVDILPQGLPGGGYGSMGVIRKRSAVSSALMFH
What is the function of this protein?
Membrane-bound E3 ubiquitin ligase expressed during late stages of lytic replication to mediate polyubiquitination of various host membrane proteins related to the immune response (PubMed:24899205).  Promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, DC-SIGN and DC-SIGNR, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes (PubMed:10859362, PubMed:11756476).  Binds target molecules through transmembrane interaction.  E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein.  The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed.  Induces ubiquitination not only on lysines, but also on cysteine residues.
What are the official names of this protein?
E3 ubiquitin-protein ligase MIR1, IE1B protein, Modulator of immune recognition 1, ORF K3, RING-type E3 ubiquitin transferase MIR1.
What are the subcellular locations of this protein?
Host cell membrane; Multi-pass membrane protein. Host endoplasmic reticulum. Note=Probably exerts its effects at the plasma membrane during viral infection.
Protein: ERA_AQUAE
Sequence: MKVGYVAIVGKPNVGKSTLLNNLLGTKVSIISPKAGTTRMRVLGVKNIPNEAQIIFLDTPGIYEPKKSDVLGHSMVEIAKQSLEEADVILFMIDATEGWRPRDEEIYQNFIKPLNKPVIVVINKIDKIGPAKNVLPLIDEIHKKHPELTEIVPISALKGANLDELVKTILKYLPEGEPLFPEDMITDLPLRLLAAEIVREKAMMLTREEVPTSIAVKINEIKPGDANPNMLVIKGEIIVDRENLKPIIIGKKGQRLKEIGKRARQELELILGRPVYLELWVKVVPDWRRRPEYVRLFGYAL
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity).  The GTPase is stimulated about 6-fold in the presence of a 12 nucleotide 16S rRNA C-terminal fragment.  Mutations in the rRNA sequence obviate stimulation.  RNA-binding depends on GTP-binding by the GTPase domain.  May function as a checkpoint for assembly of the 30S ribosomal subunit.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: FTHS_METEP
Sequence: MPSDIEIARAATLKPIAQVAEKLGIPDEALHNYGKHIAKIDHDFIASLEGKPEGKLVLVTAISPTPAGEGKTTTTVGLGDALNRIGKRAVMCLREPSLGPCFGMKGGAAGGGKAQVVPMEQINLHFTGDFHAITSAHSLAAALIDNHIYWANELNIDVRRIHWRRVVDMNDRALRAINQSLGGVANGFPREDGFDITVASEVMAVFCLAKNLADLEERLGRIVIAETRDRKPVTLADVKATGAMTVLLKDALQPNLVQTLEGNPALIHGGPFANIAHGCNSVIATRTGLRLADYTVTEAGFGADLGAEKFIDIKCRQTGLKPSAVVIVATIRALKMHGGVNKKDLQAENLDALEKGFANLERHVNNVRSFGLPVVVGVNHFFQDTDAEHARLKELCRDRLQVEAITCKHWAEGGAGAEALAQAVVKLAEGEQKPLTFAYETETKITDKIKAIATKLYGAADIQIESKAATKLAGFEKDGYGKLPVCMAKTQYSFSTDPTLMGAPSGHLVSVRDVRLSAGAGFVVVICGEIMTMPGLPKVPAADTIRLDANGQIDGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: RS19_RICAE
Sequence: MARSIWKGPFVDGYLIKKVQKLMESGKSEMIKTWSRRSTILPIFVGFTFSVHNGNKFIPVSVNEEMVGRKLGEFAPTRTFHGHGADKKIKRK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.