PharMolix/UniProtQA huggingface dataset:
Protein: IFGA_PENRF
Sequence: MGSIEPPNASSCLVYQTITEFADFPDHDQKLWWHSTAPMFAEMLKVAGYDIHSRYKALGLYQKFIIPFLGVYPTKTNDRWLSILTRYGTPFELSLNCTHSVVRYTFEPINAATGSLKDPFNTHAIWDALDTLIPLQKGIDLEFFAHLKRDLTVNDQDTAYLLEKKKVGGQIRTQNKLALDLKGGEFVLKAYIYPALKSLATGKPVQELMFDSVHRLSHQYPTLAAPLRKLEEYVHSRGTSSTASPRLISCDLCDPRQSRIKIYLLELNVSLESMEDLWTLGGRRNDTQTLAGLEMIRELWDLINLPTGILSYPEPYLKLGEVPNEQLPLMANYTLHHDDPMPEPQVYFTTFGMNDGRVTDGLATFFRRHGYTHMLQTYRDSLRAYYPHVDHDTVNYLHAYISFSYRKGSPYLSVYLQSFETGDWPISSFGAPILEPVSKKMCRGHPVSFEVPLTKQQVVASE
What is the function of this protein?
Tryptophan dimethylallyltransferase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids (PubMed:28620689).  The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:28620689).  The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan (PubMed:28620689).  The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:28902217).  The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:28620689, PubMed:28902217).  The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:28620689).  Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A (PubMed:28620689).  Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 (PubMed:28620689, PubMed:28902217).  The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions (PubMed:28902217).
What are the official names of this protein?
Tryptophan dimethylallyltransferase ifgA, 4-dimethylallyltryptophan synthase, DMATS, All-trans-hexaprenyl-diphosphate synthase, Isofumigaclavine biosynthesis cluster A protein A, L-tryptophan dimethylallyl transferase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: METE_METTM
Sequence: MITTVVGSYPATPREPETLRERISSFIGSYDACRPAIETAVRDQVRAGVDIISDGQVRGDMVGHFAEAMGGMMVKDGVSIIFSRITPPAGSIGSDDLIYAIKILRKLTDDESKGVKGIITGPSTMAHASKIEGFYSPQKRERAIMDMADALRVEAEHLQDAGALMIQIDEPFLSTGMVDMGTARRAVKRISGALDVDVSLHVCGDISGVIGELLTFPVDMLDLEFAGRPSNLEVLAEKWRGDKKLGFGCVDTSTEVVESTDTIKNLIERGADIAGEDNLYIDPDCGMRKLPREAAFSKLRNMVKAASEF
What is the function of this protein?
Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation.  Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate.  It was proposed that, in vivo, a so-far-unidentified enzyme catalyzes methyltransfer from 5-methyltetrahydromethanopterin (5-CH3-H4MPT) to a corrinoid protein, and that the MetE gene product catalyzes the further transfer to L-homocysteine.  Is not active with L-cysteine, coenzyme M, coenzyme B, glutathione or dithiothreitol as substrate.
What are the official names of this protein?
Methionine synthase, Homocysteine methyltransferase, Methylcobalamin:homocysteine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the archaeal MetE family.
Protein: DAPE_JANSC
Sequence: MSQIPTHAPVDPVALTADLIRCNSVTPLEGGALVLLEALLSDAGFDCTRVDRGGIANLYARWGTRGNGKAFGFNGHTDVVPVGDEAAWTHPPFGAEVDGDWMYGRGATDMKSGVAAFAAAAIDFVRDTPPDGAIVLAITGDEEGESTDGTIALLDWMEEVGERIDVCIVGEPTCPEQMGDMMKIGRRGALTAFFEVIGKQGHSAYLHKVINPMPAVALLGHRLSTHTLDEGTDHFDPSTCAITTIDTGNPANNVIPAKTRMTVNLRFNDLHSGDSLTAWLREEADRVAEDTGTTIRMTTKLSGESFLTPPGDLSDLVGKAVQAETGRQPTLSTTGGTSDARFVKNHCPVVEFGLVGHRMHQVDERVRISDIEDLKRVYGRVLTEYFAG
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: ENO_CHLCV
Sequence: MLEVVISDIQAREILDSRGYPTLYVKVTTDAGTFGEACVPSGASTGIKEALELRDQDSSRFQGKGVLQAVKNVKEVLLPVLQGISIFDQILIDSIMVEADGTPNKEKLGANAILGVSLASAKAAAATLGRSFYRYLGGCFAHVLPCPMMNLINGGMHANNGLQFQEFMIRPIGATSLKEAVRMGADVFHSLKNILNEKNLATGVGDEGGFAPQLKSNSEALDLLVLAIEKAGFQPGEDISLALDCAASSFYDTKAETYDGKSYEEQVNILADLCDRYPIDSIEDGLAEEDFDGWELLTAELGESIQIVGDDLFVTNPELIADGISRGLANAVLIKPNQIGTLTETSEAIQLAHSQGYTTILSHRSGETEDTTIADLAVAFNTGQIKTGSLSRSERIAKYNRLMAIEEELGPEGLFKDSNPFSGE
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RUBR1_PSEOL
Sequence: MSRYQCPDCQYIYDENKGEPHEGFHPNTSWNDIPKDWACPDCAVRDKVDFIFLADSPSKETQLGVNSQLANSESGISDATPTGMAVLAAELVIPLNQENKNEGCAAKTEVLDQASTPQVVRKSSTRKKMRNK
What is the function of this protein?
Not known.  Probably involved in an electron transport pathway, but not required for the hydrocarbon hydroxylating system.  Seems to be non-functional.
What are the official names of this protein?
Rubredoxin-1, Rdxs.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_LISMC
Sequence: MLFEQIAANKRKTIFIILGFFIFVLMVGAAIGIIVWNNYLNGLILAAVIGAFYILIMVMSSSSVVMAMNHAKEVTSKDQAPVLWDTVESMAMVAGIPMPKVYIVEDASPNAFATGISPEKGAVAVTRGLLNKLERYELEGVIAHEISHIRNYDIRLSTIAIALVAVIAILSDLAMRMIFWGSLTGGRNNRKSDNNNSGGAQAIIYIVALIFVILAPIIATAIQFALSRNREYLADASAVELTRNPDGLIQALQKISGDSKKMEEVSASSESIYFASPLKSKKNKPGLFDSHPPISSRIERLENM
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DKK4_HUMAN
Sequence: MVAAVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPRDEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGTHAEGTTGHPVQENQPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEGQVCSRRGHKDTAQAPEIFQRCDCGPGLLCRSQLTSNRQHARLRVCQKIEKL
What is the function of this protein?
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6.  DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation.  In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
What are the official names of this protein?
Dickkopf-related protein 4, Dickkopf-4, Dkk-4, hDkk-4.
What is the protein family that this protein belongs to?
Belongs to the dickkopf family.
What are the subcellular locations of this protein?
Secreted.
Protein: PIP_LACHE
Sequence: MEIIEGKMPFMGYETYYRIVGERSEKPPLVLLHGGPGSSHNYFEVLDELAQKDGRRIIMYDQLGCGESSIPDDHPELYTKETWVKELEALREHLALRKMHLLGQSWGGMLAIIYMCDYHPEGIQSLILSSTLSSASLWSKELHRMIKYLPIEEQAAIHRAELTGNFNDPDYLKANEHFMNQHAIDMTKTWPECVMRKKRGGTVAYETAWGPNEYTPEGNLHDYEYTDKLSKIKVPTLITSGTDDLCTPYVAKTMQDQIASSKWRLFEGCGHMSFVEKTDEYVALLQEWLDQHDE
What is the function of this protein?
Releases the N-terminal proline from various substrates.  Hydrolyzes only di- and tripeptides with proline in the first position.
What are the official names of this protein?
Proline iminopeptidase, PIP, Prolyl aminopeptidase, PAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family.
What are the subcellular locations of this protein?
Cell envelope.
Protein: OR2A_DROME
Sequence: MEKQEDFKLNTHSAVYYHWRVWELTGLMRPPGVSSLLYVVYSITVNLVVTVLFPLSLLARLLFTTNMAGLCENLTITITDIVANLKFANVYMVRKQLHEIRSLLRLMDARARLVGDPEEISALRKEVNIAQGTFRTFASIFVFGTTLSCVRVVVRPDRELLYPAWFGVDWMHSTRNYVLINIYQLFGLIVQAIQNCASDSYPPAFLCLLTGHMRALELRVRRIGCRTEKSNKGQTYEAWREEVYQELIECIRDLARVHRLREIIQRVLSVPCMAQFVCSAAVQCTVAMHFLYVADDHDHTAMIISIVFFSAVTLEVFVICYFGDRMRTQSEALCDAFYDCNWIEQLPKFKRELLFTLARTQRPSLIYAGNYIALSLETFEQVMRFTYSVFTLLLRAK
What is the function of this protein?
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates.  The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration.  May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
What are the official names of this protein?
Odorant receptor 2a.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TDRD7_CHICK
Sequence: MQEPDLVAKALRSVLHSSKHGIPLSELQDEYRSLTGEWIPFRHLGYATLEAYVASIPEVVRIERNQTGEVTCHAVACPETIYVRVWAVAHKRTSPIFLLFCCRQNIEKTLQMIRVLDICAIFKDPRWSSEVSFVVSVSVCLRRDQLSHHGFKRSCTFTCPEGLPLIQMVSFPIKSILSEKGLIPAYEKNHSNSEFYFSLTDNLNASGVETHTVASGRSVPNISEIQNRIKEILSKYRNGVWLSKIAQVYEETYREELSTTVLRQLEHWPHVCTVEKVRTGDQTYRILYPSKRIPPAVKSNTEQDQASQNVTSSKAGPVLKTSREAESASCSSDFKQNVVNILVKYPCGLWADALPKLYQDAYQRKFPEGILNNLQLLSDVCVVDYVSNVPQKAILYVKTQSCTDENLNVTEKVQIPDGAKATAEQQHEESKEQYPESISSVPPLVIPSEGPVSVLVIDVNNPNELIIRYVGKDYSGAQEQMEDKMKAYYSKNSTASQITFPSVGQLVAVHTEEEAWLRAQIISVEDKRLKLSCFCTYFGCITFRMCKPKENTHCCMKQCTSHKCKLTGLEVFSDDPLLLKAVELQAYHKICAVEILERSDIPVFVLYDTSGEDDININATCLKALYDKSFELNLQVDTLYTNVRVTSILSDGNMYCQLPSEGLSKLSEVLQKIEYYLLHQETSEFNVSQPYCGKICLFLCKGKWTRVEITIIHSRRALGVRFIDTGRVAYVKVTDLREIPSQFLREVIKIPPQAIKCCLADLPPDTGMWTPEAVLWLRDNVMDYAEFSMQVSVMEKRCVLKFWKAFIPISYLLADRSINRRINAVLWKHQKDVFLSVTSQGLAPPKHLNQGRLEKSDSLEPAVESRGVESATDVPPPLPLSEVGGFMDVYVSVACHPGHFIVQPWKEIHNLEALMEEMILYYSMAEERPVNIGTNKLYAAKIENRWYRVIVKGILRKGFLSVYVLDYGKHEVISIDKVQPLLDKFRKLPFQAIKAELAGVKSQQWSEEASIIFRNRVEKKPLVAQIQAINESTNSWDRKVVTYLVDTSIPDTDVWIHDFVCQSLAELSEAD
What is the function of this protein?
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation.  Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens.  Also required during spermatogenesis.
What are the official names of this protein?
Tudor domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the TDRD7 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to cytoplasmic RNA granules.
Protein: FTSB_SALDC
Sequence: MGKLTLLLLALLVWLQYSLWFGKNGIHDYSRVNDDVVAQQATNAKLKARNDQLFAEIDDLNGGQEAIEERARNELSMTKPGETFYRLVPDASKRAATAGQTHR
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: PETN_SYNP6
Sequence: MELLTFGWAALLAVFTFSLAMVVWGRNGDGSIGF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: VKT3_ANTAF
Sequence: HSSNDFCYLPAVRGRCRGYFPRYFFSSETGKCERFIYGGCGGNRNNFESAQECGSTCYPRE
What is the function of this protein?
Protease inhibitor.
What are the official names of this protein?
PI-actitoxin-Axm2b, PI-AITX-Axm2b, AXPI-III.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RS3_STRP7
Sequence: MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFVQKELADAAVSTIEIERAVNKVNVSLHTAKPGMVIGKGGANVDALRAKLNKLTGKQVHINIIEIKQPDLDAHLVGEGIARQLEQRVAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGADIARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RL18E_PYRAB
Sequence: MKRTGPTDPNLRRLIRYLRKKSNEEKVKIWKDIAWRLERPRRQRAEVNVSRINRYAKDGDMIVVPGSVLGAGKIEKKVIVAAWKFSETARRKIEEAGGEAITIEELIKRNPKGSGVIIME
What are the official names of this protein?
50S ribosomal protein L18e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL18 family.
Protein: NRX11_ORYSJ
Sequence: MADAAGIATVLAADGRDFLLRNSADQVKISSIEASTVALYFSASWCPPCRRFTPKLIEAYNELVSQGKNFEVVFVSGDKDQEAFDAYFAKMPWLAVPFSDSECRAKLNKRFKVRGIPHLVILNATSGEVYTEDGVELVTVHGTEAYPFTTERINELKEQEKAAKDNQTVQSVLGTPTRDYLLSNKGDRVPISDLEGKYVGLCFVVNGYGPVVQFTSLLAKFYEKLKEVGEKFEVVAVSLDSDEELSNESFAGMPWLAIPQEDKMGEKLARYFELRGLPTLVLIGPDGKTLNNNVADIIDEHGQDAWEGFPFTAEKMEILAEKAKAKAELQTLESLLVIGDLDFVLGKDGAKVPVSELVGKTVLLYFSAKWCGPCRAFLPKLVDEYNKIKEKHNDFEIIFISSDRDQSSYDEFFSGMPWLALPLGDERKQHLSKTFRVRGIPSLVAIGADGRTVARDAKTPLTAHGADAFPFTEERLLEMERKIDEMAKGWPGKLKHELHDEHELVLTRCTTYGCDGCDEMGSSWSYRCRECDFDLHPKCALGKEEEKKGDDEAEAEADPACEGGVCRKA
What is the function of this protein?
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
What are the official names of this protein?
Probable nucleoredoxin 1-1, OsNrx1-1.
What is the protein family that this protein belongs to?
Belongs to the nucleoredoxin family.
Protein: PACA_ONCNE
Sequence: MSSKATLALLIYGIIMHYSVYSSPLGLNYPNLRLENEVYDEDGNSLPALAFDSDQIAIRSPPSVADDLYTLYYPPEKGTERHADGMFNKAYRKALGQLSARKYLHSLMAKRVGGGSTMEDDTEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYRQRYRNKGRRLGYL
What is the function of this protein?
PACAP plays pivotal roles as a neurotransmitter and/or a neuromodulator.
What are the official names of this protein?
Glucagon family neuropeptides.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: ASQH2_EMENI
Sequence: MDRNSFTAYGPATGAITESGEQENDHTKPHTWKTFAKYACFESEAERQWWNDSGALIARFLSLTNGDIDQQYQCLLFVRQVLIPALGPYPPVRRCCINTTEIGMELSLNFQGPGEPVFRVSIDPVSRMTGTPMDPLNINTVNNMITRLASMGIKGFDRTLHHHFTREFCMSEQSMQSYQRDSGEAIAWSQTILAFDFKGGDVVTKQYIWTRHAARASGLHPHSLIRRAISRVENQMHCSAAVELVLEYMETFNADIPVPFFSWDLVDPTQSRFKIYGISWQWSWAKAEEVCTLGGKLNHHDIDLLKKLWHILKLDEFTPTMGFTWNYEIRPGQPKPEVRLYLAICDRSDEEVAQAVVQWFELLGWHERAQSYPETLRYLHKTKSAHTWLSVTVSEKGVYTSLYYHPLGNGSDDFKIRENWF
What is the function of this protein?
Prenyltransferase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934).  Within the pathway, the prenyltransferase asqH2 performs the second alkylation with DMAPP at delta(3') double bond to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain (By similarity).  The first step of the pathway is catalyzed by the nonribosomal pepdide synthetase asqK that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin.  4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ.  AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin.  The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase asqI.  4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B.  The prenyltransferase asqH1 then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase asqF to yield conjugated aryl diene.  The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase asqH2 to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain.  The FAD-dependent monooxygenase asqG performs epoxidation of the terminal C7'-C8' olefin.  Finally, after dehydratation of the epoxide at C3 by asqC, the quinolone epoxide rearrangement protein asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone (Probable).
What are the official names of this protein?
Prenyltransferase asqH2, 4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqH2, Aspoquinolone biosynthesis protein H2.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: BJAI_BRADU
Sequence: MIHAISAVNRHLYEDVLEQHFRLRHDIFVEERHWETLRRPDGREVDSYDDEDTVYLLALEGRRVVGGHRLYPTTKPSMMSEVFPHLAAVRGCPSDPLIWEWSRYFVVRDRRDGALNLQLMAAVQEFCLDQGIAQVSAIMETWWLPRFHEAGFVVTPLGLPALVENAWTMAATVDIRRQTLDVLHDRIGMPSIVQQDGPRLDAVARANLCGLAAAQRKSA
What is the function of this protein?
Catalyzes the synthesis of IV-HSL (isovaleryl-homoserine lactone), a quorum-sensing (QS) autoinducer molecule which binds to BjaR1 transcriptional regulator to activate expression of QS-dependent genes.  Is active with isovaleryl-CoA but cannot use isovaleryl-ACP as acyl donor.
What are the official names of this protein?
Isovaleryl-homoserine lactone synthase, IV-HSL synthase, Autoinducer synthesis protein BjaI.
What is the protein family that this protein belongs to?
Belongs to the autoinducer synthase family.
Protein: UXUA_SALCH
Sequence: MKQTWRWYGPNDPVTLSDVRQAGATGVVTALHHIPNGEIWSVDEIQKRKAIVEEAGLEWSVVESVPIHEDIKTHTGQYDLWIKNYQQTLRNLAQCGIYTVCYNFMPVLDWTRTDLEYVLPDGSKALRFDQIEFAAFELHILKRPGAEADYTAEEIAQAERRFATMSEEDKARLTRNIIAGLPGAEEGYTLDQFRQHLATYKDIDKAKLREHFAYFLKAIIPVADEVGVRMAVHPDDPPRPILGLPRIVSTIEDMQWMVETVNSMANGFTMCTGSYGVRADNDLVDMIKQFGPRIYFTHLRSTLREENPKTFHEAAHLHGDVDMYEVVKAIVEEEHRRKAEGSDDLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEVRGVELAIQRAFFSK
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: GLYA_ECOL5
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLEPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLVAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGSEELYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKTYQQQVAKNAKAMVEVFLERGYKVVSGGTDNHLFLVDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRVGTPAITRRGFKEAEAKELAGWMCDVLDSINDEAVIERIKGKVLDICARYPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y0419_RHIME
Sequence: MTRMKILTEAELRGIVPLDREAVACVEDAFRALATKAVAMPPILRLDIPEHRGEVDVKTAYVPGLDGFAIKISPGFFDNPKIGLPSTNGMMVLLSSKTGLVQALLLDNGYLTDVRTAAAGAVAARRLSREDSSVAAVFGAGMQARLQLEALALVRPIREARIWARDAAKAEAAAIALGGKLGFAVKAETDPRAAITGADIIVTTTPSETPVLKAEWLEPGQHVTAMGSDAEHKNEIDPHAIARATYVADSLKQTRRLGELHHAIAAHLMSAEAEFPELGQVIAGLKPGRTRADEITIADLTGTGIQDTAIATLAFARANAADAGTTFES
What are the official names of this protein?
Putative dehydrogenase RB0419.
What is the protein family that this protein belongs to?
Belongs to the ornithine cyclodeaminase/mu-crystallin family.
Protein: SYW_ALIF1
Sequence: MSKPIVLSGVQPSGELSIGNYLGALRQWQQMQDDYDCQYCVVDLHAITVRQDPKALHEATLDALAICLAVGVDPKKSTLFVQSHVPEHAQLGWLLNCYTQMGELSRMTQFKDKSARHSNDVNVGLFDYPVLMAADILLYGAHQVPVGSDQKQHLELARDIATRFNNIYSPEAPIFTVPEPYIPQVNARVMSLQDATKKMSKSDDNRKNVITLLEEPKSILKKINKAQTDAEMPPRIAHDWENKAGISNLMGLYSAATGKTFEEIEAQYQGVEMYGPFKKDVGEAIVTMLEPIQEEYKRIREDRAYMDAVMKAGAEKASERAAVTLKKAYEAVGFVTRP
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCW14_YEAST
Sequence: MRATTLLSSVVSLALLSKEVLATPPACLLACVAQVGKSSSTCDSLNQVTCYCEHENSAVKKCLDSICPNNDADAAYSAFKSSCSEQNASLGDSSSSASSSASSSSKASSSTKASSSSASSSTKASSSSASSSTKASSSSAAPSSSKASSTESSSSSSSSTKAPSSEESSSTYVSSSKQASSTSEAHSSSAASSTVSQETVSSALPTSTAVISTFSEGSGNVLEAGKSVFIAAVAAMLI
What is the function of this protein?
Component of the inner layer of the cell wall.
What are the official names of this protein?
Covalently-linked cell wall protein 14, Inner cell wall protein.
What is the protein family that this protein belongs to?
Belongs to the CCW14 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI- anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI- CWP).