PharMolix/UniProtQA huggingface dataset:
Protein: GLPK_CALS4
Sequence: MAKYVMALDQGTTSSRAIIFDHSGKMIASLNKEFRQIYPKPGWVEHDPMEIWESQIEVAKGVIEKAGIKPEDIAAIGITNQRETTVVWDKNTGKPIYNAIVWQCRRTAPICDDLKNKGFDKKIREKTGLVVDAYFSGTKVKWILDNVEGAREKAERGELLFGNIDTWLIWNLTRGKVHVTDYSNASRTMLFNIHELKWDKEILEELNVPENMLPEVKPSSHVYGYTDKSIFGVEIPIAGDAGDQQAALFGQACFKPGMAKNTYGTGCFMLMNTGEKAVPSKTGLLTTIAWGIDGKVEYALEGSIFITGAAIQWLRDELRIIDNAPQSEEYALKVEDTNGVYVVPAFVGLGAPYWDMYARGVIVGLTRGAKREHIIRATLESIAYQTRDVLEAMQEDSGIKLQALKVDGGASANNFLMQFQADILGVPVDRPQVIETTALGAAYLAGLAVGFWNSREEIEKNWNIDRRFEPAMEEEKREKLYRGWKKAVERAMKWAEE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RH37_ORYSJ
Sequence: MRSSWADSVANAEESAPATGAAPTPVANHQNSRPTRSAYVPPHLRGQAPTTTAAPAPAPGPAAVQPSASVQPSGYAAIVGGSRWAGPASGDGTGAVGGPRQSVGGRGGGGGGGGGWNSRPGWDRRDREPNPFANSEAEEATEVDFDTANTGINFDAYEDIPVETSGHDVPPPVNTFAEIDLGDALNENIRRCKYVKPTPVQRYAIPISIAGRDLMACAQTGSGKTAAFCFPIISGIMSSRPPQRPRGSRTAYPLALILSPTRELSVQIHEEARKFAYQTGVRVVVAYGGAPIHQQLRELERGVEILVATPGRLMDLLERARVSLQMVKYLALDEADRMLDMGFEPQIRKIVEQMDMPPRGVRQTMLFSATFPKEIQRMASDFLADYIFLAVGRVGSSTDLIAQRVEFVLEADKRSYLMDLLHAQKANGTHGKQALTLVFVETKRGADALENWLYTNGFPATSIHGDRTQQEREYALRSFKSGATPILVATDVAARGLDIPHVAHVINFDLPNDIDDYVHRIGRTGRAGKSGLATAFFNEGNLSLARPLCELMQEANQEVPQWLERYSARSSFGGGGGRNRRSGGARFGGRDFRRDNRGGGGGGYGGGGGGYGGGGYGGGGGYGGGYGGGQGSTSSWD
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 37, OsPL10a.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
Protein: PYRE_HAHCH
Sequence: MHDYQKAFIEFAIQREVLKFGQFTLKSGRSSPYFFNAGLFNTSTTLAQIGHFYAAALTSSPLQYDMLFGPAYKGIPLVSALAVTLANEKSMDVPYAFNRKEAKAHGEGGVIVGAPLKGKVLIVDDVITAGTAIREVISIIKANGAEPAGVLIALDRQERGQHQLSAIQEIEQNYQIPVTAIIQLDQILEFLKSDPHFSDNYKQVAEYRAVYGVQS
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: SAS5_CAEBR
Sequence: MSNYDRVPCSIAIPNQQVEIQQQPRVFEDQESPVKTKVQQPPPEQVRVPPTVIGATATAKKKSCLSTTSSRKEPPAHPALRRKTVAFGRTVNVSQTVEGTSRHTKKAIASPSQNHRMTEENQEENWRDVMKNEFEVMRKEMQEEATKKQEELNAQNLNKMQEMMSQFFQQITVAKPSAEESQDREKENWYEQSRHARQQKPANKIAKAREIIKREGSIPPEALPILEQRIRTDPMFRQQIDNVLADAECDANRAAYSPLPPLSPPSGRYANGSSGNPALMRETLTVERSIRYDNGLSSIDSRQWTSERNDNRTHDNYRPYEPDPQLQSMYQKGQSVSYYPSEAVGKAHRNNRLEYHVEEVPEYEEEETEVGGRGRGRKYHEPMETESAAERERRIREKYSRRK
What is the function of this protein?
Required for centrosome duplication.  Essential for daughter-centriole formation.  Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis (By similarity).
What are the official names of this protein?
Spindle assembly abnormal protein 5.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles. Shuttles between centrioles and the cytoplasm throughout the cell cycle. Requires zyg-1 for centriole localization (By similarity).
Protein: AROE_NITHX
Sequence: MMTAETKGRAACLIGWPAAHSRSPLIHHYWLRLHGIAGGYNIEAIPPEGLAEFIMHLSTHGFVGANVTIPHKERALQLTAPDERARAIGAANTLYYDGKTLRSTNTDVEGFIGNLDAAAPGWDRTGDALVLGAGGSSRAVVFGLIERGIKRIHLVNRTMERAQALADQFGATVMPLAWSGLGDVLPRAGLLVNTTSLGMKGQPPLDIELPLLPLDAVVADLVYVPLETPLLAAARARGLRTADGLGMLLHQAVRGFELWFGQRPAVSPELRALVEADLRIPHPAT
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: ACPS_CUPTR
Sequence: MIYGIGTDIIQIARVQGVMTRTNGRFAEKVLGPDELAKYHARKARSEKRGLAFLATRFAAKEAFSKAIGLGMRWPMTWRAMELMNLPSGEPTAVCHGELAAWLAERGLVVRVSVSDEHDYAVAFAIAERSGAAVSQPTAL
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN662_HUMAN
Sequence: MLENYGAVASLAAFPFPKPALISQLERGETPWCSVPRGALDGEAPRGISSGYPFLKPAGISHPEQVEEPLNLKLQGEGPSLICPEGVLKRKKEDFILKEEIIEEAQDLMVLSSGPQWCGSQELWFGKTCEEKSRLGRWPGYLNGGRMESSTNDIIEVIVKDEMISVEESSGNTDVNNLLGIHHKILNEQIFYICEECGKCFDQNEDFDQHQKTHNGEKVYGCKECGKAFSFRSHCIAHQRIHSGVKPYECQECAKAFVWKSNLIRHQRIHTGEKPFECKECGKGFSQNTSLTQHQRIHTGEKPYTCKECGKSFTRNPALLRHQRMHTGEKPYECKDCGKGFMWNSDLSQHQRVHTGDKPHECTDCGKSFFCKAHLIRHQRIHTGERPYKCNDCGKAFSQNSVLIKHQRRHARDKPYNCQISHLLEH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 662.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYP_BACMK
Sequence: MKQSMVFSPTLREVPADAEIKSHQLLLRAGFMRQNASGIYSFLPFGLKVLHKVERIVREEMERAGAVELLMPAMQASELWQESGRWYSYGSELMRMKDRNAREFALGATHEEVITDLVRDEIKSYKKLPLTLYQIQTKFRDEQRPRFGLLRGREFLMKDAYSFHATQESLDEVYSGLYKAYSNIFARCGLNFRAVIADSGAMGGKDTHEFMVLSDVGEDTIAYSDTSDYAANIEMAPVVATYTKSDEAEKALEKVATPDQKAIEEVSAFLNIAAEKCIKSMVFKVDAKLVVVLVRGDHEVNDVKVKNVYGASVVELASHEEIKELLNCEVGSLGPIGVTGDIEIIADHAVASIVNGCSGANEEGFHYVNVNPERDFKVSQYTDLRFIQEGDQSPDGNGTILFARGIEVGHVFKLGTRYSEAMNATFLDENGKTKPLIMGCYGIGVSRTVAAIAEQFNDENGLVWPKSVAPFHVHVIPVNMKSDAQREMGENIYNSLQEQGYEVLLDDRAERAGVKFADADLFGLPVRVTVGKKADEGIVEVKVRATGESEEVKVEELQTYIANILK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTGDS_GORGO
Sequence: MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPAADGGLNLTSTFLRKNQCETRTMLLQTAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCLTEQ
What is the function of this protein?
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation.  Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes.  Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter.  Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier.  It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity).  Involved in PLA2G3-dependent maturation of mast cells.  PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
What are the official names of this protein?
Prostaglandin-H2 D-isomerase, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS, PGDS2.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
Protein: MIER1_PONAB
Sequence: MAEPSVESSSPGGSATSDDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIHELLSLYGYGSTVRLPEEDEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVASQDAQEIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGICRYKENEKVYENDDQLLWDPEYLPEDKVIIFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCNFDTEEALRRLRFNVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSNSQSEKEDGTVSTTNQNGVSSNGPGEILNKEEVKVEGLHINGPTGGNKKPLHADMDTNGYETDNLTTDPKLAHMTARNENDFDEKSERPAKRRRVNSNGKESPGSSEFFQEAVSHGKFEELENTDD
What is the function of this protein?
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes.  Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing (By similarity).
What are the official names of this protein?
Mesoderm induction early response protein 1, Early response 1, Er1, Mi-er1.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYY2_ENTFA
Sequence: MNSAFFEELKARGLVYQVTDEEALQKQLNEESVKLYIGFDPTADSLHIGHLLPILMLRRFQQNGHVPIALVGGGTGMIGDPSFKDAERSLNTLDTVKAWSESIKGQLSRFIDFEDEKNPAILANNYDWLGELSLIDFLRDVGKNFTINYMMSKESVKRRIETGISYTEFAYQLLQAYDFLKLYETEGCLLQLGGSDQWGNITSGIELLRREQEVQGFGLTMPLITKADGTKFGKTEGNAVWLDAEKTSPYEFYQFWINTDDRDVVKFLKYFTFLTLDEIATIEEEFTANPGQRAAQKALAKEVTTLVHGEAAYHQAVKISEALFSGDIQSLTAEEIKQGFKDVPTYEVQPEDQLSLVDLLVTSKIEPSKRQAREDVQNGAIYVNGERRQDLAAELTETDKIEGQFTVIRRGKKKYFLLKY
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase 2, Tyrosyl-tRNA synthetase 2, TyrRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIGL6_HUMAN
Sequence: MQGAQEASASEMLPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLPTTLPASYYGYGYWFLEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQISLSLFVHWKPEGRAGGVLGAVWGASITTLVFLCVCFIFRVKTRRKKAAQPVQNTDDVNPVMVSGSRGHQHQFQTGIVSDHPAEAGPISEDEQELHYAVLHFHKVQPQEPKVTDTEYSEIKIHK
What is the function of this protein?
Putative adhesion molecule that mediates sialic-acid dependent binding to cells.  Binds to alpha-2,6-linked sialic acid.  The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
What are the official names of this protein?
Sialic acid-binding Ig-like lectin 6, Siglec-6, CD33 antigen-like 1, CDw327, Obesity-binding protein 1, OB-BP1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: TRMFO_AQUAE
Sequence: MKEKVIVIGGGLAGSEAAWRLANEGHRVILYEMRPKKMTPAHKTGNLAELVCSNTLGGLELTTGAGLLKAEMQKLGSLVIEAAKVARVPAGGALGVDRKIFSEYITEKIESHPNITLIREEVKEIPEDEVVVIATGPLTSDALSEKIKELVGYDTLYFYDAIAPIVEAESVDFSKGFWGSRYGKGGDDYFNCVLTEEEYKKFYEELLKAEKVKPKDFEKAVHFEGCLPIEEMAERGYKTLLFGPMKPVGLVDPRTGKEPFAVVQLRKENKEGTLLSLVGFQTKLTYKEQKRVFRLIPCLRNAVFVRLGSMHRNTFIQSNKVLTHYLNLKKKENIFFAGQITGVEGYVASSATGILAGINAGRLARGEKPLKAPTETMLGALVNYIVTKEGELQPMNPVFGLLPPLEKKVRDKKKRKELMAKRALETMEKWIKENNLVPEGLVKVC
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UXAC_ECOLC
Sequence: MTPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHYKWRAMRTNGVAERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDPIDSLEHHAEIAKDGSFTIKVLPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHALDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGALRNNNLRQFKLLGPDVGFDSINDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLGTMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLGLLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: TGT_YERP3
Sequence: MKYELQKTDGRARRGRLVFERGVVETPAFMPVGTYGTVKGMTPEEVKETGAQILLGNTFHLWLRPGQEIMKLHGDLHDFMQWHGPILTDSGGFQVFSLGAMRKIKEEGVHFKNPINGDSVFLSPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAARSRQRFDELNNKNALFGIIQGGVYEDLRDVSVKGLVDIGFDGYAVGGLAVGEPKEDMHRILEHVCPQIPEDKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKHKDDTATLDEHCDCYTCRHYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRQAIEEGKLEHFVEDFYGRIGKPVPPLNV
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RS15_THEP3
Sequence: MLDKEKKAEIINKFKLHDTDTGSPEVQIALLTERINNLNAHLQVHKKDHHSRRGLLKMVGQRRALLNYLMKTDMERYRAIIEKLDLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: Y3579_MYCTO
Sequence: MPGNSRRRGAVRKSGTKKGAGVGSGGQRRRGLEGRGPTPPAHLRPHHPAAKRARAQPRRPVKRADETETVLGRNPVLECLRAGVPATALYVALGTEADERLTECVARAADSGIAIVELLRADLDRMTANHLHQGIALQVPPYNYAHPDDLLAAALDQPPALLVALDNLSDPRNLGAIVRSVAAFGGHGVLIPQRRSASVTAVAWRTSAGAAARIPVARATNLTRTLKGWADRGVRVIGLDAGGGTALDDVDGTDSLVVVVGSEGKGLSRLVRQNCDEVVSIPMAAQAESLNASVAAGVVLAEIARQRRRPREPREQTQNRMI
What are the official names of this protein?
Uncharacterized tRNA/rRNA methyltransferase MT3685.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: SURA_XANC8
Sequence: MTKPFSVLLASLLVITSTVSPLASAQQSQPLDRIAAIVDEDVVLQSELDRAVRNVKSQYAGRDNQLPPDDVLQRQVLERLVLVKLQVGRAEGSGIRVSDEELNRAIASIAQQNGTSVDGLRQKLAADGMGYADFRASVRDEIIVQRLRQSFAQSRISVSEGEVDTALAQQATTGSQYHLAHILVGLPEGATAEQIATGQKKVDGVKALIDKGELDFSAAAVRYSDSPNALEGGDLGWRSLDEIPNAFAQLIRDMQPGQVAGPLRGPSGFQLLKLVEMRDANAGGEKKVLTEYNARHILVRIGDNQTEAQAKAKIDTLRARIVGGADFQATAKESSEDTNSRGQGGDLGWFPADAFGPDFGKQVEGLTDGAVSEPFRTQAGWHIVQRVGTRQTDVSAENQRAQIRETIGRRKLEEEYNRYLQELRGEAFVSFRTGDRADADATAAPEPAAAPAAPTPPPAQPTR
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: RLMC_PHOLL
Sequence: MQCAHYSAGHCHSCQWLEKPYSQQLEDKQQNLKQLLPQAIVKQWLPPIASQQDAFRNKAKMVVSGSVERPLLGMLHRDGTAVDLCHCPLYPAHFQPVFDVVKSFIACAGLTPYNVARKRGELKYLLLTESRHSGEMMLRFVLRSETKIAQLERALPRLHEQLPQLTVISANIQPIHMAILEGEKEILFTEQKAFKEQFNGIPLYIRPHSFFQTNPKMASELYATAGRWVRELKISSMWDLFCGVGGFGLHCADKNTCLTGIEISSEAIDCARDSAKTLGLENIEFQALDSTHFAVAKDQIPQLVLVNPPRRGIGKVLCDYLSKMVPDYILYSSCNAQTMAKDIAALANYRVEKTQLFDMFPHTEHYEVLTLLVLNHN
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: DPOL_HPBDB
Sequence: MPQPLKQSLDQSRWLREAEKHLRELENLVDSNLEEEKLKPQLSMGEDVQSPGIGEPLHPNVRAPLSHVVRAATIDLPRLGNKLPAKHHLGKLSGLYQMKGCTFNPEWKVPDISDTHFDLQVINECPSRNWKYLTPAKFWPKSISYFPVQAGVKAKYPDNVMQHEAIVGKYLNRLYEAGILYKRISKHLVTFKGKPYNWELQYLVKQHQVPDGTTTSKINGRAENRRRRAPAKSISRPHDSERDCNMVGQISNNRSSIRPCANNGGGKHYATTRRLACWGGKTIGTDQSYSSRDTSATVDSRGRSESSRGFSTISGRKATGNHHHCSNVTNSVETTTRGRSTPGKQVVTRDSSALPESRASRACHKDSSPQKEENAWYLRGNTSWPNRITGKLFLVDKNSRNTTEARLVVDFSQFSKGKNAMRFPRYWSPNLSTLRRILPVGMPRISLDLSQAFYHLPLNPASSSRLAVSDGQHVYYFRKAPMGVGLSPFLLHLFTTALGSEIARRFNIWTFTYMDDFLLCHPNARHLNSISHAVCSFLQELGIRINFDKTTPSPVNDIRFLGYQIDQKFMKIEESRWKELRTVIKKIKIGAWYDWKCIQRFVGHLNFVLPFTKGNIEMLKPMYAAITNKVNFSFSSAYRTLLYKLTMGVCKLAIRPKSSVPLPRVATDATPTHGAISHITGGSAVFAFSKVRDIHIQELLMVCLAKIMIKPRCILSDSTFVCHKRYQTLPWHFAMLAKQLLSPIQLYFVPSKYNPADGPSRHKPPDWTALTYTPLSKAIYIPHRLCGT
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery (By similarity).
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: GRPE_RALPJ
Sequence: MKHTSDTPSNSDMPSDSQATQPNASATGQAAHAYSSQAQRASADAQAVAGDEAAVAEAVADVDVAELRRQLEAAEEKARQNYENWARATAEGENIRRRGQDDVAKAHKFAIEGFAEYLLPVMDSLQAALADTSGDATKLREGVELTLKQLYAAFEKGRVTELNPVGEKFDPHRHQAISMVPADQEANTVVAVLQRGYTLADRVLRPALVTVAAPK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAKP_CERS4
Sequence: MDRRSFITKAAVGGAAASALAAPALAQSAPKVTWRLASSFPKSLDTIFGGAEVLSKMLSEATDGNFQIQVFSAGELVPGLQAADAVTEGTVECCHTVGYYYWGKDPTFALAAAVPFSLSARGINAWHYHGGGIDLYNEFLSQHNIVAFPGGNTGVQMGGWFRREINTVADMQGLKMRVGGFAGKVMERLGVVPQQIAGGDIYPALEKGTIDATEWVGPYDDEKLGFFKVAPYYYYPGWWEGGPTVHFMFNKSAYEGLTPTYQSLLRTACHAADANMLQLYDWKNPTAIKSLVAQGTQLRPFSPEILQACFEAANEVYAEMEASNPAFKKIWDSIKAFRSEHYTWAQIAEYNYDTFMMVQQNAGKL
What is the function of this protein?
Part of the tripartite ATP-independent periplasmic (TRAP) transport system TakPQM involved in the uptake of alpha-keto acids.  This protein specifically binds alpha-keto acids including pyruvate, oxobutyrate, oxovalerate and 4-methyl-2-oxovalerate.  Ligand-binding affinity increases with the increasing chain length of the aliphatic backbone of the ligand.  Is not able to bind alpha-ketoglutarate.
What are the official names of this protein?
Alpha-keto acid-binding periplasmic protein TakP, Extracytoplasmic solute receptor protein TakP, TRAP transporter alpha-keto acid-binding subunit P, TRAP-T family sorbitol/mannitol transporter, periplasmic binding protein, SmoM.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 7 family.
What are the subcellular locations of this protein?
Periplasm.