PharMolix/UniProtQA huggingface dataset:
Protein: SMLA_DICDI
Sequence: MEEIKETVEKKNKEKKYLNDYKIISEGNNIKVLQKKDFKPKFSLVSYKNYEQNFDFENAKIVSTNFAIDRHIKMKNPPDPFVFIKMPSSKLVQSQLKLYYENEGYKDIPVWITPCSAFMRYIKSYPIVGTVTETMEKKKGFTNRFLSTSETKASVSVGFFGCESSMEVTSGYEYEDTVTSEETRSWSQTLNEGSYIVYQNVLVYAYIIYGGSYKPYIDQMNKFNPGLNIKFFREDKCIFFVPINRDDAFTLRYQDNTWDPVEYDVLIDYLGQNQDKWFSGGLP
What is the function of this protein?
Knockout of the gene for this protein causes small aggregate formation.  May regulate the secretion or processing of a secreted factor that regulates aggregate size.
What are the official names of this protein?
Small aggregate formation protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_BUCCC
Sequence: MKTILITQIKSQIGRLPKHKATMKGLGLRNIGDTVERKDTAAIRGMIKKVYYMISIK
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: ACKA_BACSU
Sequence: MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLYSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRLAK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.  Appears to favor the formation of acetate.  Involved in the secretion of excess carbohydrate.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO3_STRP2
Sequence: MSNSFEILMNQLGMPAEMRQAPALAQANIERVVVHKISKVWEFHFVFSNILPIEIFLELKKGLSEEFSKTGNKAVFEIKARSQEFSNQLLQSYYREAFSEGPCASQGFKSLYQNLQVRAEGNQLFIEGSEAIDKEHFKKNHLPNLAKQLEKFGFPTFNCQVEKNDVLTQEQEEAFHAENEQIVQAANEEALRAMEQLEQMAPPPAEEKPVFDFQAKKAAAKPKLDKAEITPMIEVTTEENRLVFEGVVFDVEQKVTRTGRVLINFKMTDYTSSFSMQKWVKNEEEAQKFDLIKKNSWLRVRGNVEMNNFTRDLTMNVQDLQEVVHYERKDLMPEGERRVEFHAHTNMSTMDALPEVEEIVATAAKWGHKAVAITDHGNVQSFPHGYKAAKKAGIQLIYGIEANIVEDRVPIVYNEVEMDLSEATYVVFDVETTGLSAIYNDLIQVAASKMYKGNVIAEFDEFINPGHPLSAFTTELTGITDDHVKNAKPLEQVLQEFQEFCKDTVLVAHNATFDVGFMNANYERHDLPKISQPVIDTLEFARNLYPEYKRHGLGPLTKRFGVALEHHHMANYDAEATGRLLFIFIKEVAEKHGVTDLARLNIDLISPDSYKKARIKHATIYVKNQVGLKNIFKLVSLSNTKYFEGVSRIPRTVLDAHREGLILGSACSEGEVFDVVVSQGVDAAVEVAKYYDFIEVMPPAIYAPLIAKEQVKDMEELQTIIKSLIEVGDRLGKPVLATGNVHYIEPEEEIYREIIVRSLGQGAMINRTIGHGEHAQPAPLPKAHFRTTNEMLDEFAFLGEELARKLVIENTNALAEIFEPVEVVKGDLYTPFIDKAEETVAELTYKKAFEIYGNPLPDIVDLRIEKELTSILGNGFAVIYLASQMLVQRSNERGYLVGSRGSVGSSFVATMIGITEVNPLSPHYVCGQCQYSEFITDGSYGSGFDMPHKDCPNCGHKLSKNGQDIPFETFLGFDGDKVPDIDLNFSGEDQPSAHLDVRDIFGEEYAFRAGTVGTVAAKTAYGFVKGYERDYGKFYRDAEVERLAQGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTAEWQTTHFNFHDIDENVLKLDVLGHDDPTMIRKLQDLSGIDPNKIPMDDEGVMALFSGTDVLGVTPEQIGTPTGMLGIPEFGTNFVRGMVDETHPTTFAELLQLSGLSHGTDVWLGNAQDLIKQGIADLSTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGYIEAMKANKVPEWYIESCGKIKYMFPKAHAAAYVMMALRVAYFKVHHPIYYYCAYFSIRAKAFDIKTMGAGLEAIKRRMEEISEKRKNNEASNVEIDLYTTLEIVNEMWERGFKFGKLDLYRSQATEFLIDGDTLIPPFVAMDGLGENVAKQLVRAREEGEFLSKTELRKRGGLSSTLVEKMDEMGILGNMPEDNQLSLFDELF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMAN2_CANLF
Sequence: MAAEGWIWRWGWGRRCLGRPGLPGPGPGPATPLFLLLLLGPVVADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTILTSQYVRLTPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVMVNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIISMKLFQLMVEHTPDEENIDWTKIEPSVNFLKSPKDNVDDPTGNFRSGPLTGWRVFLLLLCALLGIIVCAVVGAVVFQKRQERNKRFY
What is the function of this protein?
Plays a role as an intracellular lectin in the early secretory pathway.  Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans.  Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans.
What are the official names of this protein?
Vesicular integral-membrane protein VIP36, Lectin mannose-binding 2, Vesicular integral-membrane protein 36, VIP36.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type I membrane protein.
Protein: SEP2_EMIHU
Sequence: MALRSLTLLCAAAGASAGAIELTPDNFDELVLKSGKAAFIKFLAPWUGHCKKMKPDWDSLASTFEDSKKVLIADVDCTTGGKPLCEKYGVRGYPTIKYFNPPDEEGEDYKGGRSLDELKKFAENELGPGCSVDLMDNCSEEQKGKLKEYIDMAPEKRTEMLETLKKELADAESTHEALLKELQATYKESMDKLEKLKEESAPKIKLLKAATPAPKAEGAKDEV
What are the official names of this protein?
Protein disulfide-isomerase-like protein EhSep2.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: MTGA_RHORT
Sequence: MRTMDGRWRWGRLVLLGLFIVFLGWPLSLLMVFRVAPVPATPLMVLRLLEGEGLAKDWVPLEAIAPALRRAVIASEDGRFCQHGGFDTKELEKAWSDYQRGDRLRGASTLSMQTAKNLMLWDGRNWLRKGLEAYDTVLLEALWPKRRILEVYLNIVEWGPGIYGAEAAARHHFGVSAAALSPRQAALLAVVLPNPREWSAGRPGAYVSRRAATIQARMGAVDLGKDGACG
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: HEM3_FRATT
Sequence: MKQITIASRESKLALWQTNFVKNRIQLELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLKDVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGDYDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCHVAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: LPXB_ECOHS
Sequence: MTEQRPLTIALVAGETSGDILGAGLIRALKEHVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: NIFH_ROSS1
Sequence: MRQVAFYGKGGIGKSTTQQNTAAALASMGYRLMVVGCDPKADCTRLLLRGVRQPSVLDTLRDVGPESVQLEKVVVQGYGGVKCVESGGPEPGVGCGGRGVITAIQTLETLGAYKDDLDYVFYDVLGDVVCGGFAMPIREGYAEEIYIVCSGEYMALFAANNICKGIKKFAERGYARLGGLICNSRLVENERALVEEFARRLNTKMIHFVPRSKDVQRAEINKKTVIDYDPELPQAHEYRELARKIDENDEFTIPTPITQDELEDLMREYGIVD
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein, Nitrogenase Fe protein, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: MB3L2_HUMAN
Sequence: MGEPAFTSFPSLPVLGKLKRNMMPWALQKKREIHMAKAHRRRAARSALPMRLTSCIFRRPVTRIRSHPDNQVRRRKGDEHLEKPQQLCAYRRLQALQPCSSQGEGSSPLHLESVLSILAPGTAGESLDRAGAERVRSPLEPTPGRFPAVAGGPTPGMGCQLPPPLSGQLVTPADIRRQARRVKKARERLAKALQADRLARRAEMLTGG
What is the function of this protein?
May displace the NuRD complex from chromatin.
What are the official names of this protein?
Methyl-CpG-binding domain protein 3-like 2, MBD3-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the MBD3L family.
Protein: DEF63_ARATH
Sequence: MDIRKTYVIIFFVGILTISFSSYNIGQTRLVVIQEQEPHCIGPCEIAFGNRPCNEECTSQQYAYGFCDYQTKGEDNPQCCCYTS
What are the official names of this protein?
Putative defensin-like protein 63.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSRP_STAA8
Sequence: MAKKKSPGTLAENRKARHDYNIEDTIEAGIVLQGTEIKSIRRGSANLKDSYAQVKNGEMYLNNMHIAPYEEGNRFNHDPLRSRKLLLHKREIIKLGDQTREIGYSIVPLKLYLKHGHCKVLLGVARGKKKYDKRQALKEKAVKRDVARDMKARY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RNPA_MACCJ
Sequence: MEKAYRIKKNEDFQKIYKNGKSVANRQFIIYRQKNSENEHFRLGISVSKKIGNAVTRNRIKRAIRESFTKHKEDIIKDDFIVIARQPSKEMTTNEINKSLEHVMKIAKGFNKRIT
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: ATPE_STAAR
Sequence: MNTLNLDIVTPNGSVYNRDNVELVVMQTTAGEIGVMSGHIPTVAALKTGFVKVKFHDGTEYIAVSDGFVEVRKDKVSIIVQTAETAREIDVERAKLAKARAESHLENDDDNTDIHRAERALERANNRLRVAELK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CBID_METCA
Sequence: MEKKPKGTRTGYTTGACSAAAARAATLGLVRGRVPDQVECELPNGQRVVFAVTDGRCEGATAHAVVIKDAGDDPDVTDKARLTADVALLPEAVGAVVLKGGEGVGTITRQGLGLEVGGPAINPVPRRNIEANVREAAGDLLERAGLEVVISVPGGEEIAKRTLNYRLGIVGGISILGTTGIVHPYSTAAFRASVIQAIEVAANQGQDVVVLTTGGRTERFVMNELPQLPPVCFVQMGDFLKYALDTVVRCGLRHVVIGGMVGKLTKIAQGETITHANRNAVDTDLLADIAAEVGAPAEVCADIRNSAMARYASERMEDLGLITAFYEALGRRVIRTLRERYPDRFTLRILMCDFEANKLAEVAEEDSPGLRLSSPLPRGED
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: GLPE_SALAR
Sequence: MEQFECITVEEAYQKLHQGAAVLVDIRDPQSYAMGHAPQAFHLTNDTLGAFMREYDFDTAVMVMCYHGNSSKGAAQYLLQQGYDAVYSIDGGFEAWHRHFPADVANGA
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED18_COCIM
Sequence: MHEHSLFAPVPAAQHHDLLQQLAGVTAMQPNRIYERRLVFKPYRKPGYLKPRPGGSQDVQAPEVQRLNKMLNGGLYHVQVVGEVKLTDFGTHPSTVDATMGGTDFGNQHQNEYDISNQSWRIEFKDIPDAGTGSAVTSRLISTSRVPYGDIVPVMKAWGYDYVSEYVLEGDMFILDDTVILLHRILNFPAKHHLQGLPAFYLPPLQEMVPLDSTGGYLLQASITVQDSGNPDLMKATTQRLLGLKEHLKSAVRLESADRLSLDTRVK
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 18, Mediator complex subunit 18.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YQCA_BACSU
Sequence: MSKLDEMTAYLPPFLTKLKEMAELLKAEAPEFEKQNNSIFDLTDQLFVTTATWGLERWEKILNVPRESGDTDEIRRLRLISKMSNIPPATYRAIEHALNRFLKNPSAQVRLLPGEYRFKVDIDIDDMQHMSELIETLENMKPAHLAYTLRAALNEPLQIKDTVILNNRRYRKASELKVGYSVTLNNNEVVLV
What are the official names of this protein?
Uncharacterized protein YqcA.
What is the protein family that this protein belongs to?
To B.subtilis XkdU.
Protein: Y1524_METMA
Sequence: MIPIKFKGRTISRGCAEGEVLISRDPISFLGSVDPRTGIVVEEKHSLAGKSIKGKVLVFPHGKGSTVGSYVMYQLKKNEAAPAAIINLETEPIVAVGAIISEIPLVDMLEKDPYEFLKDGDTVLVNGSEGYIELLKQGEGQAKK
What are the official names of this protein?
UPF0107 protein MM_1524.
What is the protein family that this protein belongs to?
Belongs to the UPF0107 family.
Protein: ZNT9_DANRE
Sequence: MFPCLAHRPWQVLCRVYLQQRAPLSQRSSKISKPCFGWQSRGGVHKLWFSFPDFRVTSLTWTQVQNCSTSGSGKDGSPTRPEEPKTTEKAQAAQPAAKGAGSKPQGLTKAESIQVKVRAVLKKREYGLKYTQNNFITAVRAMNEFCLKPSDLEHLRKIRRRSPHDDTEAFTVFLRSDVEAKALEVWGSQEALARERDQRKEVEREYQENIFRNQKLLKEYKDFWGNTKPRSRKRATFLQGPGKVVMVAICINGLNFFFKLLAWVYTGSASMFSEAIHSLADTCNQALLALGISQSVRNPDAIHPYGFSNMRYIASLISGVGIFMMGAGLSWYHGIMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAINEIKKSARTQGLSFYEYVMQSRDPSTNVVLLEDAAAVLGVVLAAGCMGLTSLTGNPYYDSLGSLGVGTLLGTVSAFLIYTNTEALLGRSIQAEHMQKLTEFLENDPAVRAIHDVKATDMGLSKVRFKAEVDFDGRVVTRSYLEKQDIEQILNEIQQVKTPEELENFMLKHGENIIDTLGAEVDRLEKELKQRNPEVRHVDLEIL
What is the function of this protein?
Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health (By similarity).  In nucleus, may function as a secondary coactivator for nuclear receptors (By similarity).
What are the official names of this protein?
Proton-coupled zinc antiporter SLC30A9, mitochondrial, Solute carrier family 30 member 9, Zinc transporter 9, ZnT-9.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Nucleus. Cytoplasm. Cytoplasmic vesicle. Endoplasmic reticulum. Note=Mainly in the cytoplasm. Partial co-localization with endoplasmic reticulum.
Protein: VIRF_YERE8
Sequence: MASLEIIKLEWATPIFKVVEHSQDGLYILLQGQVSWQNSSQTYDLDEGNMLFLRRGSYAVRCGTKEPCQLLWIPLPGSFLSTFLHRFGSLLSEIRRDNSTPKPLLIFNISPILSQSIQNLCAILERSDFPSVLTQLRIEELLLLLAFSSQGTLFLSALRHLGNRPEERLQKFMEENYLQGWKLSKFAREFGMGLTTFKELFGTVYGISPRAWISERRILYAHQLLLNCKMSIVDIAMEAGFSSQSYFTQSYRRRFGCTPSQARLTKIATTG
What is the function of this protein?
Transcriptional activator of the Yersinia virulence regulon.
What are the official names of this protein?
Virulence regulon transcriptional activator VirF.
Protein: TRPC_RUMCH
Sequence: MILDKIAASTKIRVENLKKEVSFSFVKSEASKLVNKSPFAFEKAVKDGELTFICEIKKASPSKGLISENFPYIDIAKDYEAAGAGAISVLTEPEFFLGSDQYLKDVKKTVSIPVLRKDFTIDPYQIYEAALIGADCVLLICALLDTDTLKEYIKIADGLGLSCLVEAHDENEVKSAIEAGSRIVGVNNRNLKTFEVDITNSIRLRELVPSDISFVSESGIRTAQDISALRRIGASAVLIGETLMRSGDTGAELAKLRGSA
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: RSBT_BACSU
Sequence: MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAISELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGAGLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR
What is the function of this protein?
Provides the crucial link between the upstream module (communication of environmental stress) and the downstream module (integration of the environmental signals with signals of energy stress) that compose the signal transduction pathway controlling the sigma-B factor.  Phosphorylates and inactivates its specific antagonist protein RsbS thanks to its serine kinase activity.  Upon phosphorylation of RsbS, RsbT is released to stimulate RsbU, a PP2C phosphatase, thereby initiating the signaling cascade that ultimately activates sigma-B.  The activity of the RsbU phosphatase may be stimulated by a long-lived interaction with RsbT and the serine kinase function of RsbT is not required to directly modify RsbU.  Also phosphorylates RsbR thanks to its threonine kinase activity, preventing it to phosphorylate RsbT.
What are the official names of this protein?
Serine/threonine-protein kinase RsbT, Anti-sigma-B factor RsbT, Switch protein/serine kinase.
Protein: RLMN_AGRFC
Sequence: MQAPAGLAVKAPLIANSDLMSGKPSLIGLTREEMGEALAEIGVPQKQVKMRVSQLWNWLYVRGVSDFDNMTNVAKELREKLKAAFTIARPEIVEEQISNDGTRKWLMRFPPRGAGRPVEIETVYIPEEGRGTLCISSQVGCSLTCSFCHTGTQRLVRNLTAEEILSQLLLARDRLGDFPDGSTPVGAYVPSEGRKVSNIVMMGMGEPLYNFEHVKTALLIATDGDGLSLSKRRVTLSTSGVVPEIFRTGDEIGVMLAISLHAVRDDLRDMLVPINKKYPLKELIEACRNYPGVSNARRITFEYVMLKDVNDSLEDAKMLVQLLKGVPAKINLIPFNPWPGTNYQCSEWAQIEKFADFINQAGYASPIRTPRGRDILAACGQLKSESERMRKTERLAFEAMMIANHGADD
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIM_SUHVK
Sequence: MPPSMIRVLYATDGCAITYSLMLLTGQEPSGAVYVVSYAWDGAGLDEAFSLPGERAEAELLARRPGVTFCLTGHVASVRVRPVFVAAATPAVVRALCRGEPLAARDVLEAMDEAATFALHDGLIAALTMVLEQVRPRTGNAEYAPERPLRSIAVGRRGLTSLFVHHETQTLAAFRRLYGNHNTPFWYVARFGPEEKTLVLATRLHLFHPRPAYDLRALKDLLLTYNPRVDPNPSGLDPAGLLSFAALSRFCCLSGYARGPAAAHAARYVDERVRADRAEMGVLRDYISHDRGSLKLPDREFVTYVYLAHFESFNRARLREHLDAVNVTDPAAPVGRSPLGERAAAAFFRHVRAQLNIRDYVAQNVTPSVARLAPAMGAGYVEDRTYAALAADAPRGLCDAAAGLARRVTAVEERLAPHGWVRAPDEEQQQPGADGAVLRRLLELAAAPGGGRARTALGALLGLPDACPPAPVYRVELAHRRQAFAVLAGDAWGRATARRDAAPEMAAHEPAAQMYVSRHEVFNARLAVTNIVLDVDFRLARPVPAGTLEAAMRGFRRAVLDALALLFPEADGDWAAHPCYVYKSACPPGGALAAAAGSASAASSDDGLEEAPWDDDAALADFGAAPGDEDWADWDAGVPAEVYTCDDDEVGVGIGGAGGDPGASALVRAPVPADERPPCGCRAKMGFRVCTPVPSPYAVAGADTVRGLARVLQQAVLLERDFIEPMGPYLQDFTFVDTGVYAHGRSLRLPFFAKVDGGGCHGRLLPFGDAPPGFDDPRNFHFHARPAHAVTRVLHSLGGEYESFFERKAARNREAFFARRTPLADMLRGLAVDAEDRRALEAFVADVAMAPVLRHLDAHFNGRAHEYAGATAQRVVAKPDWVLFQLCGSARFSCLRARHARSPPARTFVALSVDAHDRLCISLSQQCFATKCGSNATRTIFTAEVGQSCSSAGARCTSSSSG
What is the function of this protein?
Essential component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA primase family.
What are the subcellular locations of this protein?
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Protein: RS10_SYNPW
Sequence: MSTAIAQQKIRIRLKAFDRRMLDLSCDKIIETADTTAATAIGPIPLPTKRKIYCVLRSPHVDKDSREHFETRTHRRIIDIYSPSAKTIDALMKLDLPSGVDIEVKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: KPTA_ECOLU
Sequence: MAKYNEKELADTSKFLSFVLRHKPEAIGIVLDREGWADIDKLILCAQKAGKRLTRALLDTVVATSDKKRFSYSSDGRCIRAVQGHSTSQVAISFAEKTPPQFLYHGTASRFLDEIKKQGLIAGERHYVHLSADEATARKVGARHGSPVILTVKAQEMAKRGLPFWQAENGVWLTSTVAVEFLEW
What is the function of this protein?
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P).  May function as an ADP-ribosylase.
What are the official names of this protein?
Probable RNA 2'-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: GPDA_LEPCP
Sequence: MQITVLGAGAWGTAVAAQAALRHPTLLWGRDPAQMAEIAATRRNQRYLPDADLPARLVCSGDWDAALAHVSARAGTDADANGAGLVIVATPMAALREMLARIPQGLPTLWLCKGFEAGTGLLGHEIAREVAPQLACGVLSGPSFALEVARQQPTALVAASQHESVRDAAVRALHGASLRVYASDDPVGVEVGGAVKNVLAIATGIADGMGLGLNARAALITRGLAEMTRLGLALGARAETFMGLSGLGDLVLTATGDLSRNRRVGLRLADGQTLAQILAELGHVSEGVYSAGTVLERAGRLGVDMPITAAVVAVLQGGLAPRDAVAALMQREARAES
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_VIBA3
Sequence: MSLADQVLAVNDDLPIRTDKPVHSGKVRSVYWLTEEDSQRLIKEKGYDVAPDAPLAIMVISDRISAFDCIWRGEGNLKGVPGKGAALNAISNHWFKLFKDNGLADSHILDIPHPFVWIVQKARPVMIEAICRQYITGSMWRAYANGEREFCGIEMPEGLEKDKKLPELLITPSTKGILKGIPGVPEADDVNITRNNIEDNFAAFNFTQASDIAHYEKLLKEGFNVISQALANVDQTFVDTKFEFGYVNDAQGKEKLIYMDEVGTPDSSRIWDTQEYNKGNIVENSKEGFRQFLLNYFPDADILLNKERMPEREALARDNELPLDSLMSLSRTYLDIAAKITGAEIVLSENPKQEIIDVLRADYGLID
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: CYSE_STAEQ
Sequence: MLKRMRDDIKMVFEQDPAARSTLEVITTYAGLHAVWSHLIAHKLYKNRRYVAARMISQLSRFFTGIEIHPGAKIGKRLFIDHGMGVVIGETCTIGDNVTIYQGVTLGGTGKEKGKRHPDIGDNVLIAAGSKILGNIKIESNVNIGANSVVLQSVPSYTTVVGIPGHIVKQEGRRIGKTFDHRNLPDPLYEQIKHLERQLEKAKNGEIQDDYII
What are the official names of this protein?
Serine acetyltransferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.