PharMolix/UniProtQA huggingface dataset:
Protein: UPPP1_STRCO
Sequence: MSAISIGQAVVLGAVEGVTEFLPVSSTGHLKIVEGLMGIPVDDDAVIGFSAVIQVGAIAAVLVYFSKDIMRIVSAWGRGLRDREERYHHDYRFAWWVIYATIPIVLVGLAAKPLIKGPLASLWVVAGSLIVGSGVMWWADRTGRHKRGEDDTSFKDAMLVGGSQILALLFPGFSRSGATMSTALMLDLDRVAATRLSFFLGIPALTGAGLYELKDALGTGAGAAPLAVGTLVSFVVAYASIAWLLKFVAKHTFNSFVVYRIAVGVLLFGLLGTGVLHS
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 1, Bacitracin resistance protein 1, Undecaprenyl pyrophosphate phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MTAD_SYMTH
Sequence: MERLVIEGGTVLPMTGQADVYENGVVLVEAGRIVYAGPRDGAPHLAGARRIDASGRIVMPGIVNTHCHAAMTLLRGYADDMRLMEWLQTKIWPAEARMTADDVYWGTALGAYEMLSGGITTFLDMYFPADAVARAIQDTGIRGIVARGIIGVGGPSEALSRLDESREAFHRWNGKAGGRITFMVGPHAPYTCPPDALQACAELADELGVGIHIHLSETRDEVEEARRNWGKSPIRHVYDLGLMKGRHVVAAHCVHVDDDDIAILAETGTGVCHCPVSNLKLASGRTPVAKMRRKGVAVGFGTDGASSENMLHILGSEMRIGAIQAKELEGDPAVYTAYDAVAMATIEAARVLGMESEIGSLEPGKKADLILIDAERPHLTPNHDVFALIAYSALPGDVVMTIVDGRIVYEDGRLTTMDGREIMARVREAAARLVRE
What is the function of this protein?
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively.  Is also able to deaminate adenosine.
What are the official names of this protein?
5-methylthioadenosine/S-adenosylhomocysteine deaminase, MTA/SAH deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
Protein: KAD_DESAP
Sequence: MNLLIMGPPGGGKGTQCEVLVRELKITHISTGDMFRENVKGGTELGLKAKEYMDAGQLVPDELVVAMVKDRLSKPDCANGFLLDGFPRTVPQAEALDATLKDMGIILDAVLNIAVPRGKLLDRLTGRRVCRVCGATFHVLFNAPKEDGKCDKCGGELYQRSDDTEATVNQRLDVYEAQTQPLIEYYGKQGLLKEINGDQEIGKVTQDLLASLGR
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_STRT2
Sequence: MIFDKEDYKAFDPELWNAIDAEAERQQNNIELIASENVVSKAVMAAQGTLLTNKYAEGYPGKRYYGGTAVIDVVETLAIERAKKLFGVKFANVQPHSGSQANAAVYMSLIQPGDTVMGMDLSAGGHLTHGAPVSFSGKTYNFVSYNVDKESELLDYDAILAQAKEVRPKLIVAGASAYSRIIDFAKFREIADAVGAYLMVDMAHIAGLVASGHHPSPVPYAHVTTTTTHKTLRGPRGGLILTDDEDIAKKLNSAVFPGLQGGPLEHVIAAKAVALKEALDPAFKEYGENVIKNAAAMADVFNQHPDFRVISGGTNNHLFLVDVTKVVENGKVAQNVLEEVNITLNKNSIPYEQLSPFKTSGIRVGSPAITSRGMGEAESRQIAEWMVEALENHDKPEVLERIRGDVKVLTDAFPLY
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCMA_RICBR
Sequence: MLSFHQLKFNIYQKQLFDNLSITFLDSAITYIKGANGCGKTSLLRMIAGIMQPSNGNIFYKNLNINNIAKPYCTYIGHNLGLKLEMTVFENLKFWSEIYNSVETLDAAIHYFKLYDLLDEKCYTLSSGLQKVVALARLIACQSDLWLLDEVETNLSKENRDLLNNLIVMKANSGGIVLLSSHTENHIKSAQILQLT
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PDE5A_MOUSE
Sequence: MERAGPNSVRSQQQRDPDWVEAWLDDHRDFTFSYFIRKATRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLQQSPHADNTTPGAPARKISASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTPPRFDSDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFHMECEEVGKPSDPLTREQDANKINYMYAQYVKNTMEPLNIPDVTKDKRFPWTNENMGHVNTPCIGSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQALSAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIDEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALAEQQEKMLLNGESSQGKRD
What is the function of this protein?
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides.  This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.  Specifically regulates nitric-oxide-generated cGMP.
What are the official names of this protein?
cGMP-specific 3',5'-cyclic phosphodiesterase, cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family.
Protein: CAD22_RAT
Sequence: MRPRPAGALRAGAALSPVLLLLLLLQLLGHLWAASTPAPSSLSPGTQQDNQLGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGTIKYTISGEGAGTIFLIDELTGDIHATERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLREESGSGGDAFKVTTDSDTQEAIIVVQKHLDFESQQVHTVVLEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRDSDLEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEEPSNPHFSLLDIEDNTAAVHTQHVGFNRQEQDVFLLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLALLILTLRRHHKSHLSSDVDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDPGGGAASPPQAASSSERHSLPRGPSSPEPDFSVFRDFISRKVALADADLSVPPYDAFQTYAFEGAGSPAASLSSLHSGSTGSEQDFAFLRAWGPRFRPLAALYAGHRGDDEAPAS
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.  PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.
What are the official names of this protein?
Cadherin-22, Pituitary and brain cadherin, PB-cadherin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NS3A_BCHK5
Sequence: MMSMRSRRSMFIEHFNELMMRVQRPPTLLLILLVANAFSKPIGTPMPEHCSTLVGREFQSCIRQAQFDTAGMYTNRVIVLDRARTHRYPIDRDTTTAHDTSYDTSDPQLLSDIGYSFDYGK
What are the official names of this protein?
Non-structural protein 3a, ns3a, Accessory protein 3a.
Protein: COX41_RAT
Sequence: MLATRALSLIGKRAISTSVCLRAHGSVVKSEDYALPSYVDRRDYPLPDVAHVKLLSASQKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNKGTNEWKTVVGLAMFFIGFTALVLIWEKSYVYGPIPHTFDRDWVAMQTKRMLDMKVNPIQGFSAKWDYNKNEWKK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial, Cytochrome c oxidase polypeptide IV, Cytochrome c oxidase subunit IV isoform 1, COX IV-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase IV family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: NCBP2_SINCH
Sequence: MSVKLNALTSDSYIDVSQYRDQHFKGNRYDQEKLLKQSHTLYVGNLSFYTTEEQVHELFSKSGDVKRIIIGLDKVKKTACGFCFVEYYTRAGAENAMRFINGTRLDDRIIRADWDAGFKEGRQYGRGKSGGQVRDEYRQDYDPARGGYGKLAQQHRPTEAIRNTF
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export.  The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore.  The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus.  The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E.  The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs.  The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2.  The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD).  During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference.  The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation.  In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure.  The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 2, 20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, CBP20.
What is the protein family that this protein belongs to?
Belongs to the RRM NCBP2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MUTS2_EXIS2
Sequence: MNANALRVLEYDKLKELLAKQTASSLGAQFVRKMEPAEDFEQVKALLALTTEATTVYRLRDRYPFGGLTDVRSEVKRAEIGSVLSTSELLAVADVVYSGRQVKAFQERLHEDHPDLRLPALDSRIEQITKLVEIEQGIRHAIDDQGTVQDSASDKLRALRSQLRSLEGQVRSKIDGVLRNKSKMLSDAIVTMRNDRYCVPVKQEYRQAFGGIVHDQSASGATLFIEPQAVVAANNEIQEARLKERAEIERILAQLSALVGSVGDSLRINVDVLAELDFIMAKALYGHTIRAVEPRLNENRHIVLKEARHPFIPDDEVVPITVSLGGEFTSLVITGPNTGGKTVTLKTIGLLQLMVQSGLYVPAADETELSVFDAIYADIGDEQSIEQNLSTFSSHMTNIVSMMGKIDFMSLVLFDELGAGTDPTEGAALAIAILDEVKRRGARVAATTHYSELKAYGYNREGVVNASMEFDVESLSPTYRLLIGVPGRSNAFEISKRLGLEDRVIDAARDQVGTDAQSVETMIGRLEEAKQRAESLERELLQEQQRLVEEREEFEREQAEIHQEKNEILAKAEEKATRAVERAQKEAEAVIKRLKELRDAGAVKEHELIEARKQLEQAKPSLQDQRIAKVKAKTNQAPVFAKGEEVKVTTFNQKGYIINQNSNGEYTVQVGIMKVNVKPSDLAKVGEVKSASKTKKRSGGTSITKQSAASAELDLRGVRVEEGLAKLDRFMDQALLSNYEQIRVIHGLGTGAMRQGVQEYLRGNRHVKTHRLGGQGEGGHGVTIIELK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: ISPD_ECO7I
Sequence: MATTHLDVCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKHVVIAISPGDSRFAQLPLANHPQITVVDGGEERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRTIHQENT
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: MK67I_RAT
Sequence: MAEYSGPAKPTLALNPREDSQFEKDLTQIQRRAKKKKEEKLNSGVVYLGHLPSTLSESHIYDYCAQFGDIRRFRLSRSKRTGNSRGFAFVEFESEDVAKIVAETMDNYLFGERLLSCKFMPREKVHKDLFNQCNVPFHPPSFPAVKRYNQKRGHLQMLKMEYRFKKKEKLLRKKLAKKGIDYSFPSLVLPKPKKEISSIANTHGDSEANQDPTPVCTPTFLERRKSQLMEINDDDEIILKLPVSPVKEDTQKTPAPESSGKKRLRKRKSKQ
What are the official names of this protein?
MKI67 FHA domain-interacting nucleolar phosphoprotein, Nucleolar protein interacting with the FHA domain of pKI-67.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.
Protein: RR12_EUGLO
Sequence: MSTIQQLVRKRRKKIKKKKKLAALDSCPQKKCICLKVHTITPKKPNSALRKVTRVKIISISKMFTTAYIPGIGHNLQEHSMVLIRGGRVKDLPGVKYKVIRGCLDAAGVKNRKNGRSKYGVKRPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
Plastid 30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid.
Protein: RECO_STRPN
Sequence: MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSKLAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQDNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAFDFSFKYGACLCPEHYHEDKRRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQFMDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: O14I1_HUMAN
Sequence: MDNLTKVTEFLLMEFSGIWELQVLHAGLFLLIYLAVLVGNLLIIAVITLDQHLHTPMYFFLKNLSVLDLCYISVTVPKSIRNSLTRRSSISYLGCVAQVYFFSAFASAELAFLTVMSYDRYVAICHPLQYRAVMTSGGCYQMAVTTWLSCFSYAAVHTGNMFREHVCRSSVIHQFFRDIPHVLALVSCEVFFVEFLTLALSSCLVLGCFILMMISYFQIFSTVLRIPSGQSRAKAFSTCSPQLIVIMLFLTTGLFAALGPIAKALSIQDLVIALTYTVLPPFLNPIIYSLRNKEIKTAMWRLFVKIYFLQK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 14I1, Olfactory receptor 5BU1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL32_LATSS
Sequence: MAVPARRTSKTKKRMRRGHIKLNTPNVQFDATNGEYRVSHRVSPKGFYKGEQVVTPKAND
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: MTE1_ECOLX
Sequence: MARNATNKLLHKAKKSKSDEFYTQYCDIENELQYYREHFSDKVVYCNCDDPRVSNFFKYFAVNFDNLGLKKLIASCYVENKEGFSSSEAAKNGFYYEYHKENGKKLVFDDISVSSFCGDGDFRSSESIDLLKKSDIVVTNPPFSLFREYLDQLIKYDKKFLIIANVNSITYKEVFNLIKENKIWLGVHLGRGVSGFIVPEHYELYGTEARIDSNGNRIISPNNCLWLTNLDVFIRHKDLPLTRKYFGNESSYPKYDNYDAINVNKTKDIPLDYNGVMGVPITFLHKFNPEQFELIKFRKGVDEKDLSINGKCPYFRILIKNKRLQK
What is the function of this protein?
A methylase that recognizes the double-stranded sequence 5'-GAATTC-3', methylates A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease.
What are the official names of this protein?
Type II methyltransferase M.EcoRI, M.EcoRI, Adenine-specific methyltransferase EcoRI, Modification methylase EcoRI.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: SSEJ_SALTY
Sequence: MPLSVGQGYFTSSISSEKFNAIKESARLPELSLWEKIKAYFFTTHHAEALECIFNLYHHQELNLTPVQVRGAYIKLRALASQGCKEQFIIESQEHADKLIIKDDNGENILSIEVECHPEAFGLAKEINKSHPKPKNISLGDITRLVFFGDSLSDSLGRMFEKTHHILPSYGQYFGGRFTNGFTWTEFLSSPHFLGKEMLNFAEGGSTSASYSCFNCIGDFVSNTDRQVASYTPSHQDLAIFLLGANDYMTLHKDNVIMVVEQQIDDIEKIISGGVNNVLVMGIPDLSLTPYGKHSDEKRKLKDESIAHNALLKTNVEELKEKYPQHKICYYETADAFKVIMEAASNIGYDTENPYTHHGYVHVPGAKDPQLDICPQYVFNDLVHPTQEVHHCFAIMLESFIAHHYSTE
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  This protein is required for endosomal tubulation and negatively regulates the formation of Salmonella-induced filaments (Sifs) in epithelial cells.  Has both deacylase and esterification activities in vitro, but esterification is probably the dominant activity in host cells.  Significantly contributes to cholesterol esterification, which reduces cellular cholesterol in cells and abrogates the ability of SifA to associate with cholesterol and LAMP-1 vesicles.
What are the official names of this protein?
Secreted effector protein SseJ, Salmonella-translocated effector J, STE J.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. Localizes to the Salmonella-containing vacuole (SCV) at early time points following invasion and subsequently traffics away from the SCV along Salmonella-induced filaments (Sifs) in epithelial cells.
Protein: RPOB_SOLUE
Sequence: MDLQNYGAAPERVDFSKIKTSIPIPNLIEVQKKSYERFLQMDLLPNEREDIGLQTVFNSVFPISDFRGVSDLEFVDYSIGNWECKCGNLKGLHHLRSTCRNCGATIRTDPFHAGDILCHHCGTFNKNVVTFCNKCGDPVGLQLKYDMQECQERGMTYAAPLKVTIRLTVYSKDPETQKKSVRDIKEQEVFFGEIPLMTDNGTFIINGTERVIVSQLHRSPGVFFERVPAQGYFLGKIIPYRGSWVEFEYDNKNILYVRIDRKRKFYGSVFLRALGLKTDEQILRAFYRVSKMEIRDKKIYWNVDEGLTGLKLSHAITTKSGDTVVGQGKKITASLFKELQKAKIEKVEVAPNDLEGAHVVADVVDMTTGEVMIDANSELTTTVMSKLIEAGITEFEIFFPERDDVGTVIAATIRKDAVKTQNEALIEIYRKLRPGDPPTLDTATQLFQGMFFDPRKYDFSRVGRMKFNIKLYDRSDATALDKRTLDSDDFKSTIRYLLKLRKGIGAVDDIDHLGNRRVRAVGELLENQFRIGLVRMERAIKEKMSVYQEMSTAMPHDLVNAKPVMAAIREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLSRERAGFEVRDVHPTHYGRICPIETPEGPNIGLISSLSCFARINEYGFIESPYRKVIKGAVVDEVKVLNPGDTDYKVGDIVRRGDMDEANRKLGGKKQAAEFEAHCEYLSAWEEDKWTIAQANVELDEKGRIVPDLSNARQAGNFVLKPKEEIEYIDVSPKQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLRADAPYVGTGMEMVTARDSGAVVLNKRAGVVDSVDSERIIVRVEGAAHEGQLSREVGADIYQLTKFKRSNQNTCINQKPIVRVGQRVPKGAVLADGPCTDLGELALGRNVLVAFMPWRGYNFEDAILVSEKLVKEDYYTSIHIEEFEIEARDTKLGPEEITRDIPNIADSFLRNLDESGIIRIGATVKPGDILVGKVTPKGETQLTPEEKLLRAIFGEKAGDVKDASLYCPPGIEGTIVDCKIFSRKGQEKDERSKAIEESQIQRLQRNLQDEIRILTDERAKRLGTLLDGKKLLADLHDEKTNKRLLSKDTELTRELIEKMKSRDLKRMRLANKDPRLNEQIDEIEEMTSRQIAVLEKITDEKIAKLRKGDELPPGVIKLVKVYIAMKRKLSVGDKMAGRHGNKGVIARILPEEDMPYLPDGTPVEIVLNPLGVPSRMNVGQILETHLGWAAKALGVQFATPVFDGATEREIKKNLTAAGLPTSGKTALFDGMTGTQFEQPVTVGYIYMLKLSHLVDDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYILQELLTAKSDDVYGRAKIYEAIVKGEAAIEPGVPESFNVLIRELQSLCLDVELMKKPREVPDTALAAD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PSAA_NICSY
Sequence: MIIRSPEPEVKILVDRDPVKTSFEEWARPGHFSRTIAKGPDTTTWIWNLHADAHDFDSHTSDLEEISRKVFSAHFGQLSIIFLWLSGMYFHGARFSNYEAWLSDPTHIGPSAQVVWPIVGQEILNGDVGGGFRGIQITSGFFQIWRASGITSELQLYCTAIGALVFAALMLFAGWFHYHKAAPKLAWFQDVESMLNHHLAGLLGLGSLSWAGHQVHVSLPINQFLNAGVDPKEIPLPHEFILNRDLLAQLYPSFAEGATPFFTLNWSKYADFLTFRGGLDPVTGGLWLTDIAHHHLAIAILFLIAGHMYRTNWGIGHGLKDILEAHKGPFTGQGHKGLYEILTTSWHAQLSLNLAMLGSLTIVVAHHMYSMPPYPYLATDYGTQLSLFTHHMWIGGFLIVGAAAHAAIFMVRDYDPTTRYNDLLDRVLRHRDAIISHLNWACIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPVFAQWIQNTHALAPGATAPGATASTSLTWGGGDLVAVGGKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNAISVVIFHFSWKMQSDVWGSVSDQGVVTHITGGNFAQSSITINGWLRDFLWAQASQVIQSYGSSLSAYGLFFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPATQPRALSIIQGRAVGVTHYLLGGIATTWAFFLARIIAVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: WCAA_ECOLI
Sequence: MKNNPLISIYMPTWNRQQLAIRAIKSVLRQDYSNWEMIIVDDCSTSWEQLQQYVTALNDPRITYIHNDINSGACAVRNQAIMLAQGEYITGIDDDDEWTPNRLSVFLAHKQQLVTHAFLYANDYVCQGEVYSQPASLPLYPKSPYSRRLFYKRNIIGNQVFTWAWRFKECLFDTELKAAQDYDIFLRMVVEYGEPWKVEEATQILHINHGEMQITSSPKKFSGYFHFYRKHKDKFDRASKKYQLFTLYQIRNKRMTWRTLLTLLSVRNGKRLADGIRGR
What are the official names of this protein?
Putative colanic acid biosynthesis glycosyl transferase WcaA.
What is the protein family that this protein belongs to?
To R.meliloti ExoO.
Protein: MNMA_CAMJR
Sequence: MKILVAMSGGVDSTVTAYKLKNLGHEVIGCYMKLHGKPNYHEENIKKVEKVANFLQIPYHILDLQEDFKNKVYMPFVDTYKEGKTPNPCALCNRFIKLGKLLEFAKSLGCEKLATGHYARLENNLIKTAVDESKDQSYFLASADKEALKYLIFPLGEMKKEDVKKFASTIEVLKSFATQKESSEICFVEDTYVQVLDQFMDTKIPGEVLDSSGKVVGKHEGYMHYTIGKRRGFEVRGAHEPHFVLKINPKQNQIIVGTKEELKISEFNLKNINLFIDAKELDCEVKIRYRSKSTPCKVEIYEDKSAKIILKDPVYGLASGQMAVFYDHDKVIASGFIE
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.