PharMolix/UniProtQA huggingface dataset:
Protein: NVFD_ASPN1
Sequence: MLKPAIIIVPGALHRPEHYQGIVSRLHKLQYEAVAVSMPSLSSSPPQPTWTEDVEAIRKAIFKFSESGQDVVLVGHSYSGILISEASKGLSRKDLPHGEGAVVRLIYMCAIAVPVGESLTGQLEPRTPQEVEAFREEGSISLLDADKVRDVLYNKCEPKVADWAISLLGKQPVTTMSTPATHAAWLEIPSTYLICEDDLAVPECVQLRMAKQGNGAFDIVRCQEGHAPCLSNPDLVVRMIRNAAGEAIEI
What is the function of this protein?
Alpha/beta hydrolase; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety (PubMed:29968715).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase nvfA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (PubMed:29968715).  DMOA is then converted to farnesyl-DMOA by the farnesyltransferase nvfB (PubMed:29968715).  Epoxydation by FAD-dependent monooxygenase nvfK, followed by a protonation-initiated cyclization catalyzed by the terpene cyclase nvfL leads to the production of asnavolin H (PubMed:29968715).  The short chain dehydrogenase nvfC then as a 3-OH dehydrogenase of asnovolin H to yield chemesin D (PubMed:29968715).  There are two branches to synthesize asnovolin A from chemesin D (PubMed:29968715).  In one branch, chemesin D undergoes Baeyer-Villiger oxidation by nvfH, methylation by nvfJ, and enoyl reduction by the nvfM D enoylreductase that reduces the double bond between C-5'and C-6', to form respectively asnovolin I, asnovolin K, and asnovolin A (PubMed:29968715).  In the other branch, the methylation precedes the Baeyer-Villiger oxidation and the enoyl reduction to yield asnovolin A via the asnovolin J intermediate (PubMed:29968715).  Asnovolin A is further converted to fumigatonoid A by the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfI that catalyzes an endoperoxidation reaction (PubMed:29968715).  The alpha/beta hydrolase nvfD then acts as an epimerase that converts fumigatonoid A to its C-5' epimer, which then undergoes spontaneous or nvfD-catalyzed lactonization (PubMed:29968715).  The following step utilizes the ketoreductase nvfG to produce fumigatonoid B (PubMed:29968715).  The dioxygenase nvfE further converts fumigatonoid B into fumigatonoid C (PubMed:29968715).  Finally the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfF catalyzes two rounds of oxidation to transform fumigatonoid C into the end product, novofumigatonin A (PubMed:29968715).
What are the official names of this protein?
Alpha/beta hydrolase nvfD, Novofumigatonin biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: PGLT1_HUMAN
Sequence: MEWWASSPLRLWLLLFLLPSAQGRQKESGSKWKVFIDQINRSLENYEPCSSQNCSCYHGVIEEDLTPFRGGISRKMMAEVVRRKLGTHYQITKNRLYRENDCMFPSRCSGVEHFILEVIGRLPDMEMVINVRDYPQVPKWMEPAIPVFSFSKTSEYHDIMYPAWTFWEGGPAVWPIYPTGLGRWDLFREDLVRSAAQWPWKKKNSTAYFRGSRTSPERDPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLVDHCKYKYLFNFRGVAASFRFKHLFLCGSLVFHVGDEWLEFFYPQLKPWVHYIPVKTDLSNVQELLQFVKANDDVAQEIAERGSQFIRNHLQMDDITCYWENLLSEYSKFLSYNVTRRKGYDQIIPKMLKTEL
What is the function of this protein?
Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322).  Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322).  Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076).  Notch glucosylation does not affect Notch ligand binding (PubMed:21490058).  Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity).
What are the official names of this protein?
Protein O-glucosyltransferase 1, CAP10-like 46 kDa protein, hCLP46, KTEL motif-containing protein 1, Myelodysplastic syndromes relative protein, O-glucosyltransferase Rumi homolog, hRumi, Protein O-xylosyltransferase POGLUT1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 90 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: VP4_ROTGA
Sequence: MLTYLRREWQSFGETVTIKNTFNAQEDNNQSGRKTDNRPVKTEGRYCYKADVNRSKYYHDVQGFSLGQSDLHIDPTQFIMYSGTISNGISYVNQAPSCVQLSLKFTPGNSSLIEDLHIEPYKVEVLKIEHVGNVSRATLLSDIVSLSIAQKKLLLYGFTQLGIQGLTGDVVSVETKRIPTPTQTNLLTIEDSMQCFTWDMNCANVRSTKQDSRLIIYEQEDGFWKIVTETLSIKVKPYFKAYGTMGGAFKNWLVDSGFEKYQHDLAYVRDGVTVNAHTITYVNPSGKAGLQQDWRPATDYNGQITVLQPGDGFSVWYYEDKWQINQAIYAKNFQSDTRAQGYLENVGTLKFKMNYIPAFAEIRNKPGKVNYAYLNGGFAQVDASGYTGMSIILNFVCTGERFYASDNNSRVDNKITPFISYIGDYYTLSGGDFYRQGCCAGFAAGYDDVSPEHGITVSYTVMKPSDPDFITGGENYGESITSDLEVSIRNLQDQINSIIAEMNIQQVTSAVFTAITNLGELPGLFSNITKVFSKTKEALSKLKSRKKTSPMPIAATSIIDKTTVDVPNLTIVNKMPEEYELGIIYNSMRTKKLIEQKKHDFSTFTVATEVKLPYISKATNFSDQFMTSISSRGITIGKSDIIQYDPMNNILSAMNRKNAQIINYKIDPDLAHEVLSQMSTNATRSLFSLNVRKQLHINNSFDTPTYGQLVERILDDGQLLDILGKLNPNSVEELFSEFLHRIQHQLREY
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles.
Protein: FPPS1_ARTSI
Sequence: MSSSKSIDLKSKFLKVYDTLKSDLINDPAFEFDDDSRQWIQKMLDYNVPGGKLNRGLSVVDSYQLLKGGELSDDEIFLSSALGWCIEWLQAYFLVLDDIMDESHTRRGQPCWFRLPKVGMIAANDGILLRNHVPRILKKHFRGKPYYVDLVDLFNEVEFQTASGQMIDLITTLVGEKDLSKYSLSIHRRIVQYKTAYYSFYLPVACALLMFGEDLDKHVEVKNVLVEMGTYFQVQDDYLDCFGAPEVIGKIGTDIEDFKCSWLVVKALELANEEQKKTLHENYGKKDPASVAKVKEVYHTLNLQAVFEDYEATSYKKLITSIENHPSKAVQAVLKSFLGKIYKRQK
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl pyrophosphate (IPP) with the allylic pyrophosphates, dimethylallyl pyrophosphate (DMAPP), and then with the resultant geranylpyrophosphate (GPP) to the ultimate product farnesyl pyrophosphate (FPP).  Has a 4. 5 time greater affinity for GPP versus DMAPP.
What are the official names of this protein?
Farnesyl diphosphate synthase 1.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: PDXT_MYCVP
Sequence: MSAPQVGVLALQGDTREHLAALREAGAEARTVRRLDELNSVDALVIPGGESTAMSHLLREFGLLEPLRARLAEGMPAYGSCAGMILLATEIADAGVAGREALPLGGIDMTVRRNAFGRQVDSFEEDVEFEGLDGPVHAVFIRAPWVERVGPDVEVLARAGGHPVAVRQGKMLATAFHPEVTGDRRVHRLFVASLS
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: NCPP_ALIF1
Sequence: MKVIIASQNPAKIAAVESAFNLAFPNDTFSFEGVSVKSGVPDQPMSCEETKQGAMNRINNAKIKLPNCDYYVGLEAGIEGNSTFAWMIIDNGLTVGESRSSSLPLPPQVIDEVKKGKELGDVMDEQFNTDNIKQKGGAIGLLTNNLLTRTSVYQQALILALIPFLHPTRF
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: KAD_CARHZ
Sequence: MKLLIMGPPGAGKGTQAEKIVKEFGITHISTGDMFRAALKNQTPLGLKAKEYMDKGELVPDEIVIAMVEERISAPDCAKGFLLDGFPRTIPQAEALDKKLAEMGITLDGVINIEVPREELIERLTGRRVCRQCGATYHVKFNPPKVEGVCDACGGELYQRSDDSLETVSNRLDVYEAQTAPLKDYYAKTGLLKNIDGTKSIEEVFASIKNALQK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JHAMT_BOMMO
Sequence: MNNADLYRKSNSLQKRDALRCLEEHANKIKWKKIGDRVIDLGCADGSVTDILKVYMPKNYGRLVGCDISEEMVKYANKHHGFGRTSFRVLDIEGDLTADLKQGFDHVFSFYTLHWIRDQERAFRNIFNLLGDEGDCLLLFLGHTPIFDVYRTLSHTEKWHSWLEHVDRFISPYHDNEDPEKEVKKIMERVGFSNIEVQCKTLFYVYDDLDVLKKSVAAINPFNIPKDILEDFLEDYIDVVREMRLLDRCNNNVGESVSIKFNYKVISVYARKLCLSLM
What is the function of this protein?
O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis (PubMed:14530389).  Also able to methylate farnesoate to methyl farnesoate (PubMed:14530389).
What are the official names of this protein?
Juvenile hormone acid O-methyltransferase, Juvenile hormone acid methyltransferase, BmJHAMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: MEGL_PSEPU
Sequence: MHGSNKLPGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLKDMTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKASA
What is the function of this protein?
Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia (PubMed:8586629, PubMed:6742420).  Is involved in L-methionine catabolism (PubMed:9190812).  In fact, shows a multicatalytic function since it also catalyzes gamma-replacement of L-methionine with thiol compounds, alpha,gamma-elimination and gamma-replacement reactions of L-homocysteine and its S-substituted derivatives, O-substituted-L-homoserines and DL-selenomethionine, and, to a lesser extent, alpha,beta-elimination and beta-replacement reactions of L-cysteine, S-methyl-L-cysteine, and O-acetyl-L-serine (PubMed:6742420, PubMed:22785484).  Also catalyzes deamination and gamma-addition reactions of L-vinylglycine (PubMed:6742420).  Thus, the enzyme is able to cleave C-S, C-Se, and C-O bonds of sulfur, selenium, and oxygen amino acids, respectively (PubMed:6742420, PubMed:22785484).
What are the official names of this protein?
L-methionine gamma-lyase, MGL, Homocysteine desulfhydrase, L-methioninase.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family. L-methionine gamma-lyase subfamily.
Protein: RHO_STRCO
Sequence: MSEVLFPAVRRRVVRPLARLFPSLRMSHARVLERTDHMTTTLEHPPVQHAQADIASGVLDIETGGKGRLRGRNLQPEPADPALSPALIRRHGLRRGDLVEGVCGDRRTLTDVVRVNGRTPDRRSRPHFADLTPLHPHERLRLEHPAAGLAGRVVDLLAPVGKGQRGLIVAPPKTGKTVLLQQFAAAVAGNHPEARLMVVLLDERPEEVTDMRRSVRGEVYSSTFDRSARQHIALAELVIERAKRLVEAGEDVVILLDSLTRLCRAHNNAASSGGRTLSGGVDAGALLGPKRFFGAARKAEEGGSLTILATALVETGSRADDFYFEELKSTGNMELRLSREPASRRVFPAVEPVGSGTRREELLLSGAETTALRGLRRALVARDGQSGLETLLERLRRTPDNATFLRQVQPTLPAG
What is the function of this protein?
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
What are the official names of this protein?
Transcription termination factor Rho, ATP-dependent helicase Rho.
What is the protein family that this protein belongs to?
Belongs to the Rho family.
Protein: VPS25_XENLA
Sequence: MGFEWPWQYNFPPFFTLQPNVDTRQKQLSAWSSLVLSYCRQNKLYTMNLMEIQESPLFNNKKIQRKLSLESVQVVLEELRKKGNLEWIDKNKSRFLIMWRRPDEWGKVIYQWVSKNGMTNSVFTLYELISGDDTEGEEFHGLDEAMLLRSLEALQQEHKAEIITLNESRGVKFF
What is the function of this protein?
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.  The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation.  The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).
What are the official names of this protein?
Vacuolar protein-sorting-associated protein 25, ESCRT-II complex subunit VPS25.
What is the protein family that this protein belongs to?
Belongs to the VPS25 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADR_YERE8
Sequence: MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHDSVPQLIDNLLAVRTNIATIFVRTAIRNHPEKAQEILAQAQTVDDNAESFTALDYGIFRGLAFASGNPIYGLILNGLKGLYTRVGRYYFSNPEARKLALTFYSRLSTLCDEKAYDQVLDCLRAYGKESGAIWHSMQGTMPSDLAEARR
What is the function of this protein?
Multifunctional regulator of fatty acid metabolism.
What are the official names of this protein?
Fatty acid metabolism regulator protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GST67_DICLA
Sequence: NPRGLPAFKHGNXVLNESYAXMYLESQFGSXGXLIPDADVIYYNWKVPEGERHD
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase 6.7, GST-6.7, GST class-theta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECCC4_MYCTO
Sequence: MNSGPACATADILVAPPPELRRSEPSSLLIRLLPVVMSVATVGVMVTVFLPGSPATRHPTFLAFPMMMLVSLVVTAVTGRGRRHVSGIHNDRVDYLGYLSVLRTSVTQTAAAQHVSLNWTHPDPATLWTLIGGPRMWERRPGAADFCRIRVGVGSAPLATRLVVGQLPPAQRADPVTRAALRCFLAAHATIADAPIAIPLRVGGPIAIDGDPTKVRGLLRAMICQLAVWHSPEELLIAGVVSDRNRAHWDWLKWLPHNQHPNACDALGPAPMVYSTLAEMQNALAATVLAHVVAIVDTAERGNGAITGVITIEVGARRDGAPPVVRCAGEVTALACPDQLEPQDALVCARRLAAHRVGHSGRTFIRGSGWAELVGIGDVAAFDPSTLWRNVNQHDRLRVPIGVTPDGTAVQLDIKEAAEQGMGPHGLCVGATGSGKSELLRTIALGMMARNSPEVLNLLLVDFKGGATFLDLAGAPHVAAVITNLAEEAPLVARMQDALAGEMSRRQQLLRMAGHLVSVTAYQRARQTGAQLPCLPILFIVVDEFSELLSQHPEFVDVFLAIGRVGRSLGMHLLLASQRLDEGRLRGLETHLSYRMCLKTWSASESRNVLGTQDAYQLPNTPGAGLLQTETGELIRFQTAFVSGPLRRASPSAVHPVAPPSVRPFTTHAAAPVTAGPVGGTAEVPTPTVLHAVLDRLVGHGPAAHQVWLPPLDEPPMLGALLRDAEPAQAELAVPIGIVDRPFEQSRVPLTIDLSGAAGNVAVVGAPQTGKSTALRTLIMALAATHDAGRVQFYCLDFGGGALAQVDELPHVGAVAGRAQPQLASRMLAELESAVRFREAFFRDHGIDSVARYRQLRAKSAAESFADIFLVIDGWASLRQEFAALEESIVALAAQGLSFGVHVALSAARWAEIRPSLRDQIGSRIELRLADPADSELDRRQAQRVPVDRPGRGLSRDGMHMVIALPDLDGVALRRRSGDPVAPPIPLLPARVDYDSVVARAGDELGAHILLGLEERRGQPVAVDFGRHPHLLVLGDNECGKTAALRTLCREIVRTHTAARAQLLIVDFRHTLLDVIESEHMGGYVSSPAALGAKLSSLVDLLQARMPAPDVSQAQLRARSWWSGPDIYVVVDDYDLVAVSSGNPLMVLLEYLPHARDLGLHLVVARRSGGAARALFEPVLASLRDLGCRALLMSGRPDEGALFGSSRPMPLPPGRGILVTGAGDEQLVQVAWSPPP
What are the official names of this protein?
ESX-4 secretion system protein EccC4, ESX conserved component C4, Type VII secretion system protein EccC4, T7SS protein EccC4.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HTPG_WIGBR
Sequence: MQKKETLEFQSEVKQLLNLMIHSLYSNKEIFLRELISNASDALDKLRFLSISDEKIKIKQNKLCIFIDYDKNKKSITIQDNGIGMSKKEVIENLGTIAKSGTKSFIKSIEKSNSEKNNQLIGKFGVGFYSVFIVSEKVLVLTRSFKENEKNGVLWESSGKGEYTISNIIKKDVGTEITIFLKESEKEFCDELNIKNIVLKYSNHINFPIKLKTKITKDNKILTPEEKKSYTWKQINTGKSLWSKKKSEIKDIEYKEFYKNFFNDNYDPLIWSHNHVEGKQEYVSLLYIPRKASWDIWNREHKHGLKLYVKKVFIMDQSSEFIPNYLRFIKGIIDSNDLPLNVSREILQNNENIYKIKINLTKKALLMLENLSKNHPDEYKLFWKEFGLILKEGPSEDIKNYENVIKLFRFSSTYINSENQEVSLEDYVKRMQSGQNKIFYITSDNYLSAKNNPHLEKLKEKKIEVLLLFDRIDEWMMNYMTEFKKIKFQSISKYSSYLENIFKDENNDQKNTEQKLSTIILRIKSYLKDRVKDVRFTSKLTNSPSTVTTDENDITTQMSKLLISTGQESPEIKYIFELNANHPIIKHVFNIEDKNIFNNWIELLFEESILSERGNLDDPNKFIHRINNLLLSNIIRLN
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_YERE8
Sequence: MLAKRIIPCLDVKDGQVVKGVQFRNHEIIGDIVPLAQRYAQEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSVEDAGQILTFGADKISINSPALADPTLITRLADRYGVQCIVVGIDTWYDEESDSYQVYQFTGDEKRTKATTWQTEDWIKEVQLRGAGEIVLNMMNQDGVRNGYDLRQLKQMRTICHVPLIASGGAGTSEHFLEAFRDADVDGALAASVFHKQIINIGELKKYLSEQGVEIRVC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_LYSSC
Sequence: MSKVYVFDHPLIQHKLTYIRDKNTGTKEFRELVDEVATLMAFEITRDMPVEEIEIETPVTIAKTKVLSGKKLAIVPILRAGIGMVDGVLKLIPAAKVGHIGLYRDPETLKPVEYYAKLPADVEERDFIIVDPMLATGGSAVEAIHSLKKRGAKNIKFMCLIAAPEGVKAIQEEHSDVDIYIAALDEKLNDHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: YN91_YEAST
Sequence: MSIAQDRGIVFKLLSIYRAAAGIFMALAQLIVIFFGYCDFKIKGYRIASYNAPTFASSFIILAVCLLLVVVLENPEVKVTNSENSLFSALKQFFRVERKKLISCLILLWSMFLSSFIMSEVVYFMPLFLTLHVNWDTKFQGIAFMVASILGVTGSYFAPKLINVGCSCGRAKDGGLEESDTTGSETVEVKKKDSLYSGQVFLSIFALFVSLLGQAFMIGASEALKHKSMPPTNSGIFFSAGMSITLLGYNFLASSIPALFSMYIDPKLKVQLMPSIGAISGIGKLVAPIVLAALYGTRLGLSIAVGFGMILVAVSIPPLIWLRKKRC
What are the official names of this protein?
Uncharacterized membrane protein YNR062C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y3417_XANOM
Sequence: MSRVKKLHQWKERLRDRARTVSFGRFLWRRFLDDRLFQAAASLAYTTVFALVPLAIVVFGVLSAFPAFNEWKDALTDFIFTNFVPGAARSVQNYLNRSLEDLGKFTVAGMVALVASLLITLHSIEQTFNSIWRVAAARPKVTRFLIYWTVLTLGTMLAAASMAMAAYVFALPLFRTTEGQWLAEFAWRLAPMAVEFICIVLIYRVVPQHVVRLRHALPGALLAVILMEIVKWGFGVYLGNFQTYQRIYGALSALPILLLWIYLSWVSVLLGASLASSMAAFRYQPEAMRLPTGFEIYGLLRLLGRFRQARIHGEGLDEDRILALEPMLTDTLMQELLCELKRMRLLRRDERGQWLLARDLDLVPLAELYENCQLRVPIEDRPLPCRDDAYGQAAAAALEQLRQPLRSVLAQPVGDLYTHLPGDPP
What are the official names of this protein?
UPF0761 membrane protein XOO3417.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ERMP1_RAT
Sequence: MEWSSESAAVRRHRGTAERREGQAAASHPQREASAQEDARGGGRMRGRTESGGESRGAKTALSEARTALALALYLLALRALVQLSLQRLVLSRTSGLQGEFDARQARVYLEHITAIGPRTTGSAENEILTVQYLLEQITLIEEQSNSLHRISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPQDGAKYAVLANCHFDSVANSPGASDDAVSCAVMLEVLRVMAASPEPLQHAVVFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRILIDSIQRAGDNILAVLKYLATSDMLASSSEYRHGSMVFFDVLGLLVIAYPSRVGSIINYMVVMAVVLYLGRKLLRPNHSNSNYVRDFLCGLGITFISWFTSLVTVLIIAVFVSLIGQSLSWYNYFYIAVCLYGTATVAKIILIHTLAKRFYYVNASDLYLGELFFDTSLFVHCGFLVALTAQGFCSAFMSAVWVAFPLLTKLCVYKDFKKHGAKGRFIALYLLGMFIPYLYGLYLIWAVFEMFTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLVCSGAFFPYSSNPDSPKPKRVFLQHVSRTFHNLEGSVVKRDSGIWINGFDYTGMSHVTPHIPEINDTIRAHCEENAPLCGFPWYLPVHFLIRKNWYLPAPEISPRNPAHFRLVSKEKMPWDSIKLTFEATGPSHMSFYVRTHKGSTLSQWSLGNGIPVTSRGGDYFVFYSHGLQASAWQFWIEVQVSEEQPEGMVTVAIAAHYLSGENKRSSQLDALKEKFPDWSFPSAWVSTYSLFVF
What is the function of this protein?
Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures.
What are the official names of this protein?
Endoplasmic reticulum metallopeptidase 1, Felix-ina.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
Protein: YBJM_ECO57
Sequence: MKHKQRWAGAICCFVLFIVVCLFLATHMKGAFRAAGHPEIGLLFFILPGAVASFFSQRREVLKPLFGAMLAAPCSMLIMRLFFSPTRSFWQELAWLLSAVFWCALGALCFLFISSLFKPQHRKNQ
What are the official names of this protein?
Inner membrane protein YbjM.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UPK3L_BOVIN
Sequence: MGLGRGQSPLLMALLLLLACLQMGMSLERISYVPQLSSATLAGRLTQSTFTLEQPRGQFSHPSISDSDAIWLVVAHSNATQKFTAPQKVEDTPVPADFPQRGYYLTLRASRALYPGGPPSNQLRVLRVGNDTRCSPRTRGCNRPLPGPGPYRVKFLVMSDRGPMAETEWSSETRLQQAEVLQAAPGPQTAGTVVIIAILSVLLAVLLAALLALLIFTWYDTCGSTPISGPGELVFVRKYDTHHMSRPSTVGGS
What are the official names of this protein?
Uroplakin-3b-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the uroplakin-3 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: OOEP_BOVIN
Sequence: MVDNAGDYEARGDRLLGFPLPSPRVRIRPWWFPAQELRNPLVFFLEAWLADLIFGPDRALVPEMEWMSQALLMVDAVDAGNLVEVTVFARPAVQRQVKSVLLSQASVHREQRARAEKMEQLEEFLKAQAPGPQVPQHPVA
What is the function of this protein?
As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity).  Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (By similarity).  Thereby contributes to oocyte survival and the resumption and completion of meiosis (By similarity).  As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity).  Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).
What are the official names of this protein?
Oocyte-expressed protein homolog.
What is the protein family that this protein belongs to?
Belongs to the KHDC1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.