PharMolix/UniProtQA huggingface dataset:
Protein: SOX14_MACFA
Sequence: MSKPSDHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDTDPLKAAGLPVGASDGLLSAPEKARAFLPPASAPYSLLDPAQFSSSAIQKMGEVPHTLATGALPYASTLGYQNGAFGSLSCPSQHTHTHPSPTNPGYVVPCNCTAWSASTLQPPVAYILFPGMTKTGIDPYSSAHATAM
What is the function of this protein?
Acts as a negative regulator of transcription.
What are the official names of this protein?
Transcription factor SOX-14.
What are the subcellular locations of this protein?
Nucleus.
Protein: YDIF_ECOLI
Sequence: MKPVKPPRINGRVPVLSAQEAVNYIPDEATLCVLGAGGGILEATTLITALADKYKQTQTPRNLSIISPTGLGDRADRGISPLAQEGLVKWALCGHWGQSPRISELAEQNKIIAYNYPQGVLTQTLRAAAAHQPGIISDIGIGTFVDPRQQGGKLNEVTKEDLIKLVEFDNKEYLYYKAIAPDIAFIRATTCDSEGYATFEDEVMYLDALVIAQAVHNNGGIVMMQVQKMVKKATLHPKSVRIPGYLVDIVVVDPDQTQLYGGAPVNRFISGDFTLDDSTKLSLPLNQRKLVARRALFEMRKGAVGNVGVGIADGIGLVAREEGCADDFILTVETGPIGGITSQGIAFGANVNTRAILDMTSQFDFYHGGGLDVCYLSFAEVDQHGNVGVHKFNGKIMGTGGFIDISATSKKIIFCGTLTAGSLKTEITDGKLNIVQEGRVKKFIRELPEITFSGKIALERGLDVRYITERAVFTLKEDGLHLIEIAPGVDLQKDILDKMDFTPVISPELKLMDERLFIDAAMGFVLPEAAH
What is the function of this protein?
CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons.  May play a role in short-chain fatty acid metabolism in E. coli.
What are the official names of this protein?
Acetate CoA-transferase YdiF, Short-chain acyl-CoA:acetate CoA-transferase.
What is the protein family that this protein belongs to?
Belongs to the 3-oxoacid CoA-transferase family.
Protein: JIPH_ATRCA
Sequence: MASTQAMGMTEQQKKSVDEMVEKATNMGVNVQAQNSAVVSMINQTNVSMTFNENHNWSGSVVGTGYPKSIPTKQSRQFIHQGDAKDGSQGAVVYYGSNANGEPCGWLLAWCAPTNVTPTKPNRVYVDCGAQSKFDTISWDTIKAKLDVGPATTNFTDVDTETTIAAGVTSTGSFASVGAAFGLST
What are the official names of this protein?
Jasmonate-induced protein homolog.
What is the protein family that this protein belongs to?
Belongs to the jasmonate-induced protein family.
Protein: HEM3_STAAB
Sequence: MRKLVVGSRRSKLALTQSQQFIDKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLFVKEIQHELFEKNIDMAIHSLKDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTEDYDAIILAAAGLRRMGWSDDIVTSYLDIDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGSCQVPIAGYATISDQKEIEFTGLIMTPDGKERFEYTMNGTDPVELGKKVSNKLKEQGAYEIIKRLNEQH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: YIDC_ACTSZ
Sequence: MNSSRSLLALALLFISFLVYQQWEIDKAPKPVVRETAVSQSDTPNSSSASTSAVDSQAKGRVITLQNDVFRLKVDTLGGDVIESELLNYAQELNGEERFTLLENKDGTTYVAQSGLVGKNGIDSAAGRADYQVNGDNFVLAEGQDELSVPFTFEKDGVIYRKIFMLKRGSYDIAVNYEIRNQSDETIEVQPYGQLKHTLVESSGSMAMPTYTGGAYSSSETNYKKYSFDDMKGANLSVNTKAGWVAVLQHYFVSAWIPNQDADNQLYTTTNNGMGFIGFRGPTVTVPAGATETVKTALWTGPKLQNQMGEVAEHLDLTVDYGWAWFIAKPLFALLTLIQSLVSNWGLAIIGVTLVVKAILYPLTKAQYTSMAKMRMLQPKLQEMRERFGDDRQRMSQEMMKLYKEEKVNPLGGCLPLLIQMPIFIALYWTFMEAVELRHAPFFGWIQDLSAQDPYYILPLLMGGSMFLLQKLSPTPVADPMQQKVMNFMPVIFTVFFLWFPAGLVLYWLVSNVITIIQQQLIYRGLEKKGLHSRKSK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL6_DESRM
Sequence: MSRIGKKPIPVPQGVDVKINGNVISVKGPKGQLEQEFHQDMNIKLEEGNLVVERPSDAKDHRALHGLTRTLLNNMVEGVTNGFQRNLELVGVGYRAAKQGNKLVLTIGYSHPVEIEPPAGIEIEVPAATKIAIKGSDKQAVGQLAANIRAVREPEPYKGKGIKYENEIIRRKAGKAGGKGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: PHOSP_PI1HD
Sequence: MDQDAFFSERDPEAEGETPRKQESLSDVIGLLDVVLSYKPTEIGEDRSWLHSIIDNSKENKPSCKADDNNKDRAISTPTQDHRSSEESGISRRTGESKTETHARILDQQGIHRASRRGTSPNPLPENMGNERNTRIDEDSPNERRHQRSVPTDEDRKMAENSNKREEDQVEGFPEEVRRGTPLSDDREGRTNNNGRSMETSSTHSTRITDVITNPSPELEDAVLQRNKRRPTTIKRSQTRSERTQNSELHKSTSEDSSNLEDHNTKTSPKVLPSKNEESVATQKNNHNHRKTKYTTNNANNNTKSLPTPEHDTTANEEGTSNTSVDEMAKLLVSLGVIKSQHEFELSRSASHVFAKRMLKSANYKEMTFNLCGMLLSVEKSLENKVEENRTLLKQIQEEIDSSRDLHKRFSEYQKEQNSLMMANLSTLHIITDRGGKTGDPSDTTRSPSVFTKGKDNKVKKTRFDPSMEALGGQEFKPDLIREDELRDDIRNPVLEEHNNEPQASNASRLIPSTEKHTLHSLKLVIENSPLSRVEKKAYIKSLYKCRTNQEVKNVMELFEEDIDSLTN
What is the function of this protein?
This protein is probably a component of the active polymerase.  It may function in template binding.
What are the official names of this protein?
Phosphoprotein, Protein P.
What is the protein family that this protein belongs to?
Belongs to the respirovirus P protein family.
Protein: SIBG_STRSJ
Sequence: MRILVNGGGPAGMAFAMFAARSGRGDEITVRDWTGPGDTYGFGVILPPAAVEVFRDAEPDLADELNSHITAWDRLSVHRHGRTASIPAPRLGAMDRRTLLKVLRRRCAERGVRFEHGAVDPALGDHDLVVAADGARSVTRRHRAAAFGTTTREIGPAYIWLGADRALEHLRFLVAETPDGPAVAHAYPYSPDRSTFLVEADGAPPPAVLAEWFAGPLGGARLLENRSRWSRFQEIHNRTWSAGNVVLIGDAAHTAHYSIGSGTRLALDDARALADALCAQPRLADALKGYEDARRPIVEHTQRIGRLSATWFTRLPDVPMERLLDDLATRGGQISWRDLATEGSGAVPVRG
What is the function of this protein?
Involved in the biosynthesis of the antitumor antibiotic sibiromycin (PubMed:19270142, PubMed:21612226).  Hydroxylates the C5 position of the peptidyl carrier protein (PCP)-bound 4-methyl-3-hydroxyanthranilic acid (4-MHA or 3H4MAA), leading to the formation of the fully substituted anthranilate moiety found in sibiromycin (PubMed:21612226).
What are the official names of this protein?
3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase, FAD/NADH-dependent hydroxylase SibG.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family.
Protein: GATB_THEM4
Sequence: MRFKPVIGLEIHVQLNTKTKAFCSCPADVFELEPNNAICPVCTGQPGALPVPSKQMYEFGILLAAALNCKIHEFTRFDRKNYFYPDLPKGYQITQYFYPLATNGYLKLNGKKIRINRIHLEEDAGKLLHSSETITQAESTLVDMNRCGVPLAEIVTEPDIESPEEARKFLEKLRQILRYLGVSTGDMEKGALRCDANISVIDLENNVQSNKVEVKNMNSFKFVEKALEYEFNRIKKHLKKGENVVKETRGWDLASKKTISMRSKEEANDYRYFPEPDIPPVVIPKEEINKIIEKIPELPDEKINRFKIQYGLTDYEAGILTTSINLANYFEECVKETKNPKETSNWFLTELLKYISPEEVFENLKIKPKHFKELFDLISSGKITRNIAKEIFKEIFETGKNPEEIVKEKGIEVIGDESLIEDMLKKIMAENEDKVNAYKNGKKGLLGFFVGQIMKQTKGKADAKKANEIAKRLLGD
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: COQ7_FRAT1
Sequence: MRKLSFLDRVIEELDSYARFTKVPLNPSKKSPSSDTIDGKLSEIEKKHSAGLMRVDYTGEICAQGLYRGQASVAKSPQTKEHLYHAAAEEYDHLAWCGERLQELGARPSLLNPFWYWTSFGIGAVAGSISDSLSYGFVVETEKQVMKHLDSHLKSLPVNDNRSREILKQMYIDESEHAVEAEKAGGKKLPKTVKAIMKLQSKVMTTLAYRF
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SMAL1_RAT
Sequence: MSLPLTEEQRKKIEENRQKALARRAEKLWAEQPQSTASGSSAARPSQCKQNSLLNLPAEPSKPEGHATISKGQNLNNSLPAAQRPHSSPCFQPSTAEEAKGLWKSEGKMSAACPNPSPPEVSNQQLLGSKSSEGHPQATQDTAASCPRPFPRDPKLEAKAGRPSTSGQSISDTFYALGEKTPKTDGRPAKALQTSPQKASCLRGMCLRTGDRFRVKIGYNKELIEVFKSLPSRRYDSFTKTWDFSMSDYRALMKAVERLSTVSLQPLEEVDGTGGQTSLPSAPSLTFVTGRCMLISRARFEVDIGYSEVVIALFKQMESRNYDPKTRKWNFLLEEHNKLIARSRELKQVQLDPLPKTLTLAFASQLEKTSLQSKADVPEADLSGVDAKLVSNLMPFQREGVSFAISKRGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPEDINVVVTGKGRLTAGLVNIVSFDLLSKLEKQLKTPFKVVIIDESHFLKNIKTARCRAAVPILKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRLPWGWDYSGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQRKMVVVNPGRISTRAKAALDAAAKEMTKDKTKQQQKEALLVFFNRTAEAKIPCVIEYILDLLESGREKFLVFAHHKVLLDAIAKELERKNVQHIRIDGSTPSADREDLCQQFQLSKGHTVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTNSVGIHYLVAKGTADDYLWPLIQEKIKVLGEAGLSETNFSEMTEATDYLYKDPKQKTIYSLFQQSFEDDGNDMEFLEAAESFELGSTSGTSGNSSQELGDITDENALADSPPKKRRFEFFDNWDSFTSPF
What is the function of this protein?
ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA.  Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA).  Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA.  May play an important role in DNA damage response by acting at stalled replication forks (By similarity).
What are the official names of this protein?
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1, HepA-related protein, Sucrose nonfermenting protein 2-like 1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Recruited to damaged DNA regions.
Protein: SODM_STRP6
Sequence: MAIILPELPYAYDALEPQFDAETMTLHHDKHHATYVANANAALEKHPEIGENLEELLADVTKIPEDIRQALINNGGGHLNHALFWELLSPEKQDITPDVAQAIDDAFGSFDAFKEQFTAAATGRFGSGWAWLVVNKEGQLEITSTANQDTPISEGKKPILALDVWEHAYYLNYRNVRPNYIKAFFEIINWKKVSELYQAAK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
What are the subcellular locations of this protein?
Secreted.
Protein: TAL_HELPY
Sequence: MQEFSLWCDFIERDFLENDFLKLINKGAICGATSNPSLFCEAITKSAFYKDEIAKLKGKKAKEIYETLALKDILQASSALMPLYEKDPNNGYISLEIDPFLEDDAAKSIDEAKRLFKTLNRPNVMIKVPASESGIEVVSALTQASIPVNVTLVFSPKIAGEIAQILAKEAQKRAVISVFVSRFDKEIDPLVPKNLQAQSGIINATECYYQINQHANKLTSTLFASTGVKSNSLAKDYYIKALCFKNSINTAPLEALNAYLLDPNTECQTPLKTTEIEAFKKELKVHNIDLENTAQKLLKEGLIAFKQSFEKLLSSF
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_PARDP
Sequence: MSQTIPQITTGPLPGSRKIHVPGSLHDIRVPMREIAVSNEPPLVVYDSSGPYTDAAVQADIARGLPDLRGDWQLRRGDVAPYPGRQVTAADNGFAEGARLTPAFPLRRDPLRAAAGRAVTQLAYARAGIVTPEMEFAAIRENEGRLVAHARDGAPMGAELPDLVTPEFVRAEIAAGRAIIPANINHRELEPMIIGRNFKVKINANIGNSAVTSSMEEEVEKMVWAIRWGADTVMDLSTGRNIHNIRDWIIRNAPVPIGTVPLYQALEKVGGVAEDLSWEVFRDTLVEQAEQGVDYFTIHAGVRLHMIPLTARRVTGIVSRGGSIMAKWCLHHHRESFLYERFDEICEIMQAYDVSFSLGDGLRPGSIADANDEAQCAELRTLGELTKIAWARDCQVMIEGPGHVPMHKIKANMEEQLRHCHEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPDRDDVKTGVITYKLAAHAADLAKGHPGAQRRDDALSRARFEFRWQDQFNLGLDPDTAQAMHDETLPKEAHKLAHFCSMCGPKFCSMRISHDIRAEAEKQAGMARMAEKFREGGALYLPVAESVAEAAD
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: FADR_ENT38
Sequence: MVIKAQSPAGFAEEYIIESIWNNRFAPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQHPDKALEVLATANAIEDHADAFATLDYNIFRGLAFASGNPIYGLIINGMKGLYTRIGRHYFANPEARSLALGFYHKLSEICSEGMHDQVYETVRRYGRDSGEIWHRMQKNLPGDLAIHGH
What is the function of this protein?
Multifunctional regulator of fatty acid metabolism.
What are the official names of this protein?
Fatty acid metabolism regulator protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_NEIG1
Sequence: MNRLYPHPIIAREGWPIIGGGLALSLLVSMCCGWWSLPFWVFTVFALQFFRDPAREIPQNPEAVLSPVDGRIVVVERARDPYRDVDALKISIFMNVFNVHSQKSPADCTVTKVVYNKGKFVNADLDKASTENERNAVLATTASGREITFVQVAGLVARRILCYTQAGAKLSRGERYGFIRFGSRVDMYLPVDAQAQVAIGDKVTGVKTVLARLPLTDSQADPVSQAASVETAANPSAEQQQIEAAAAKIQAAVQDVLKD
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y1110_XANAC
Sequence: MRGNIAQLMQQAQKMQENLQRAQEELAKLEVTGTAGGGMVSVTLTGAKECRKVRIDPSILSDQEMAEDLIAAAFNDASNKIDAESKDRMGSATAGMQLPPGMKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein XAC1110.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL22_ECO8A
Sequence: METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKVLESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: NCAP_SHRV
Sequence: MAFQKEFFGLRDVKVDLSAGEGLDFDPSEVELTVYRTGADTDGNTIIKALAAVGGPKTNEALSVLLAFVTLGTDQDEYETRIKILKEIGFSVKEVPMAKDASSGIEAPLENVAALVKPETVYQVIRGVLYTCALFVKYNVEKMQKYIKNKLPALATSYGVPELEEFPTESSALKKLASCIRPGQRITNALYAFLLVEMARPETQQGARALAAMRINGTGMTMVGLFTQAAKNLGATPSDLLEDLCMRSLVDSARRIVRLMVQVSQAETIQARYAVMMSRMLNENYFKAYGLNDNSRISAILVAVNGHFSEDTIEALEGIKVSAEFADLARRIAIALIEKYDNASDGGEGASEIIKSAVRGSSGAFKGSRGKPQGRRQEASGEGDLDSEDDDDQDYSKYA
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA.  Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation.  The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace.  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication.  Protein N binds protein P in the NC through a different interaction, and can be phosphorylated.  Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N.  During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
What are the official names of this protein?
Nucleoprotein, NP, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the novirhabdovirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: GLYA_POLNA
Sequence: MYHRNILIEQTDPEIFAAIQAENARQEHHIELIASENYASPAVMAAQGSQLTNKYAEGYPGRRYYGGCEHVDVAEQLAIDRVKQIFGADAANVQPHCGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNDKEEIDYEAMERKAHETKPKLIIAGASAYSLAIDFERFARVAKDVGAIFMVDMAHYAGLIAAGIYPNPVPHADIVTSTTHKSLRGPRGGIILMKAQHEKIINSAIFPGLQGGPLMHVIAAKAIAFKEALSPEFKIYQQQVLKNAQIVAETLTQRGLRIVSGRTESHVMLVDLRAKGITGKEAEAVLGSAHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFGDEEARMTANLVADVLDNPRDAANIEAVRAKVHALTSRFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVB_SCHPO
Sequence: MTVLAPLRRLHTRAAFSSYGREIALQKRFLNLNSCSAVRRYGTGFSNNLRIKKLKNAFGVVRANSTKSTSTVTTASPIKYDSSFVGKTGGEIFHDMMLKHNVKHVFGYPGGAILPVFDAIYRSPHFEFILPRHEQAAGHAAQAYSRVTKKPGVVLVTSGPGATNVITPIADALADGTPLVVFSGQVATSAIGSDAFQEADMVGISRSCTKWNVMVKDVADLPRRIDEAFEIATSGRPGPVLVDLPKDVTASVLKEPIPILSSVPSMNRRMKEVLEEGSKNVTAKIDRVANLLKLAKKPVIFCGHGVLANPECPTLLRKFSERLQIPVTTSLLGLGAVDERSDLSLHMLGMHGSGYANMAMQEADLILALGVRFDDRVTGNVSLFAPQARLAAAEERGGIIHFDISPKNIGKVVQPTEAIEGDVYESLKLLDSATKNIKIPSRFDWLSQIQTWKERFPFTFTRSAPGELVKPQEVIQELDKQTSDIKDKVTITTGVGAHQMWAATFYRWTKPSSLVTSGGLGTMGFGLPAAIGASVAAPKDIVIDIDGDASFSMTGMELATVRQFDIPVKILILNNEEQGMVTQWQNLFYEKRYSHTHQKNPNFVKLADAMGIKALRVEKREDLAKKMKEFLSTKGPVLMEVLVAQKEHVYPFVPGGKALHQFILHESLS
What are the official names of this protein?
Acetolactate synthase, mitochondrial, AHAS, ALS, Acetohydroxy-acid synthase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: LLDD_SALG2
Sequence: MIISAASDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNETLSMPVALAPVGLCGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWIREFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAYLYALATAGKAGVANLLDLIEKEMKVAMTLTGAKTISEISGDSLVQELGKSLPAALAPMSKGDTA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YIGI_SHIFL
Sequence: MSAVLTAEQALKLVGEMFVYHMPFNRALGMELERYEKEFAQLAFKNQPMMVGNWAQSILHGGVIASALDVAAGLVCVGSTLTRHETISEDELRQRLSRMGTIDLRVDYLRPGRGERFTATSSLLRAGNKVAVARVELHNEEQLYIASATATYMVG
What is the function of this protein?
Displays thioesterase activity against medium- to long-chain acyl-CoA substrates (By similarity).  Is involved in the thioesterase-dependent beta-oxidation pathway of (9Z,11E)-octadecadienoate (conjugated linoleic acid or CLA), along with TesB and FadM (By similarity).
What are the official names of this protein?
Medium/long-chain acyl-CoA thioesterase YigI.
What is the protein family that this protein belongs to?
Belongs to the YigI thioesterase family.
Protein: YYBN_BACSU
Sequence: MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYGYGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQGSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW
What are the official names of this protein?
Uncharacterized protein YybN.
Protein: HTRAL_STAAW
Sequence: MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKHERFKNSLSSHLEQRNRDVNENKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDTEKSKYYEQNSEATLSTKSTDKVESTDMRKLSSDKNKVGHEEQHVLSKPSEHDKETRIDFESSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPEEQKLKRQQSQNEQTKTYTYGDSEQNDKSNYENDLSHHMPSISDDKDNVMRENHIVDDNPDNDINTPSLSKTDDDRKLDEKIHVEDKHKQNADSSETVGYQSQSSASHRITEKRNNAINDHDKLNGQKPNAKTSANNNQKKATSKLNKGRATNNNYSDILKKFWMMYWPKLVILMGIIILIVILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKASQDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKATSSDSSVKEIAIGDSNNLVLGEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNKYDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISMPNVENMSFAIPVNEVQKIVKDLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKGDVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK
What are the official names of this protein?
Serine protease HtrA-like.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: KPYM_MOUSE
Sequence: MPKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNAWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
What is the function of this protein?
Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth.  In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity.
What are the official names of this protein?
Pyruvate kinase PKM, Pyruvate kinase muscle isozyme, Threonine-protein kinase PKM2, Tyrosine-protein kinase PKM2.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
What are the subcellular locations of this protein?
[Isoform M2]: Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli. Nuclear translocation is promoted by acetylation by EP300. Deacetylation by SIRT6 promotes its nuclear export in a process dependent of XPO4, thereby suppressing its ability to activate transcription and promote tumorigenesis. SUBCELLULAR LOCATION: [Isoform M1]: Cytoplasm.
Protein: RF1_RHIL3
Sequence: MAKLPVEKMRELERRFGEIEARMSAGPAADVYVKLASEYSELQPVVTKIRVYEKAVTELADLETLLEDRSVDREMRDLAELELPEVKEQIEALEQEMQILLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAAEKGWKVEVLSASEGEAGGYKEIIATITGKGVFAKLKFESGVHRVQRVPETEAGGRIHTSAATVAVLPEAEEIDIEIRAEDIRIDTMRSSGAGGQHVNTTDSAVRITHLPSGIVVTSSEKSQHQNRAKAMQVLRSRLYDAERQRADSERSADRKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDRMMEGEIEEVVDALMADYQASQLAQLGEQQ
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.