PharMolix/UniProtQA huggingface dataset:
Protein: PGXB_NEOFI
Sequence: MKFLALAALFASTVSSIAVDGLIPGARVIPANDVVALKKVGAHHQKHPHRRTVIIRPSFNDEDDVSADFLWGIKWANRGGRLLLQKGKKYVIGKKLDLTFLKDIEVQLDGELKFTNDVPYWQANNFYYDFQKSISFWRWGGEDIKIFGSGVLNGNGQRWYNEFAGQEILDPNNKYYRPILFVTENATRVSVEGITQLNSPCWTNFFVRTKDISFNNVFIHAYSTNASALPKNTDGFDTLNVDGLTVTNTRVDIGDDCLSPKPNTTNVFVQNLWCNGTHGTSMGSIGQYPGVLDIIENVWIENVTLLNGENGARLKAWAGPNVGYGRINNVTYKNIHVENTDNPIVLDQCYFNINATQCAAYPSRVNFTNIVFENIYGTSSGKHGKVVADLTCSPNAVCSGIRLKNIHLTSPAGSPPVIVCDGIQGDIGVECQSSTNLTTKRSIGLARNLKYKA
What is the function of this protein?
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
What are the official names of this protein?
Probable exopolygalacturonase B, Galacturan 1,4-alpha-galacturonidase B, Poly(1,4-alpha-D-galacturonide)galacturonohydrolase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYC_DECAR
Sequence: MLKIYNSLKREKQVFTPIEPNKVRMYVCGMTVYDYCHLGHARVMVVFDMVYRWLKASGYDVTYVRNITDIDDKIIKRAIENGETIQQLTNRFIAFMHEDADALGVQRPDYEPRATEYVPEMLDLIGKLEANGLAYQASDGDVNYAVRKFPGYGKLSGKSLDDLRAGERVEVDSAKQDPLDFVLWKHAKPGEPAWQSPWGDGRPGWHIECSAMSSKLLGQHFDIHGGGQDLQFPHHENEIAQSEGANCCNFVNYWMHNGFVRVDNEKMSKSLGNFFTIRTVLEQFDAEVVRFFILRAHYRSPLNYSDAHLDDARRSLDSLYFALRDVPPAAADIDWSNEFAGRFAAALNEDFDSHGAIAVLFELAAEVNRQKSAGLSCLLKGLGGVIGLLEREPSAYLQGGAGVGGLDEAAVGQMIVDRAAAKKAKNFAEADRIRDELKAAGIILDDSPQGTTWRRA
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_LACJO
Sequence: MKKKGLNYLMQVAIDGPASAGKSTVAKIIAHNLGYIYIDTGAMYRACTLIAHDNNVDYGDEKAILNLIDHSTIDFKQEDGEQKVYVNGKDVSIDIRTPEITENVSQVSALRSIREKMVELQREMAGKHDVIMDGRDIGTTVLPDAEVKIFLIASVASRAKRRFLDFQEKGIHQDLKDIEHDIEVRDYKDSHREISPLKKADDAIELDTTNLTIDEVVAKITEIIQKKQKN
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_FRATO
Sequence: MKQITIASRESKLALWQTNFVKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAILSNKADIAVHSLKDVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGDYDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCHVAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: HEM1_SCHPO
Sequence: MERVVKLAAKHCPFVSKADPSALRRMAGAGLIRAGARCPVVRHALPVAAATGADVSRGFKSDSKQMAMEPSLDEIHLKAGVVNTGSRTCRHADAVKAAAEAATTTPVTKKHQMPKHYASDLNGVGPATTPRFDYDTFYREELDKKHRDKSYRYFNNINRLAKEYPLAHLADPNTRVEVWCSNDYLNMGGHKKIREAMHQCIETYGGGAGGTRNIAGHNQHAVRLEKSLADLHQKPAALVFGSCYVANDATLSTLGRKLPNCIFLSDEMNHASMINGIRNSRCEKIIFKHNDLVDLEAKLASLPLNRPKIIAFESVYSMSGNVAPISEICDLAKKYGAITFLDEVHAVGMYGPRGAGVAEETPGLLSRVDIITGTLAKSYGCVGGYIAASSTLVDMIRSLAPGFIFTTSLPPHVMVGALTAVEHLKVSNVEREQQRSAVRRVKQSLSEIGIPVLSNDTHIVPAMVGDAHLAKLASDSLLHDHNIYVQSINFPTVSVGTERLRITPTPAHNTEHYVQSLTNAMNDVWSKFNINRIDGWEKRGIDVGRLCKFPVLPFTTTH
What is the function of this protein?
Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
What are the official names of this protein?
5-aminolevulinate synthase, mitochondrial, 5-aminolevulinic acid synthase, Delta-ALA synthase, Delta-aminolevulinate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: ISPH_HISS2
Sequence: MKIILANPRGFCAGVDRAISIVELALEIHGAPIYVRHEVVHNRFVVNGLRERGAIFVEELDEVPNGAIVIFSAHGVSQAVRQEAKERNLKVFDATCPLVTKVHMQVARASRKGTKAILIGHEGHPEVIGTMGQYDNDKGGIYLVEDVEDIAKLTLRNDEDITFMTQTTLSIDDTAGVIEVLKQKYPAIQGPRKNDICYATTNRQQAVRELAKLSDLVIVVGSKNSSNSNRLAELASRMGVTAKLIDDANDIEVSWLDNVTVIGLTAGASAPEILVQSVISRLKELGVDKVEELEGCEENTVFEVPKELRIKEVE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RK18_SPIOL
Sequence: MAAATSLSFFHSTLASSSSSSVQQLSLPPKFVNFRPQTLPLIQAKAHTRREDRTARHVRIRKKVEGTPERPRLCVFRSNKHLYVQVIDDTKMHTLAAASTMQKAISENIDYSAGPTVEVAQKIGEMIAKSCLEKGITKVAFDRGGYPYHGRVKALADAAREHGLVF
What is the function of this protein?
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
What are the official names of this protein?
50S ribosomal protein L18, chloroplastic, CL18, Chloroplastic large ribosomal subunit protein uL18c.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RIFK_METAC
Sequence: MRLKIKAIWVPTVPDIEYLKKLALRGAVNKTVKVSSSEFHKHTGDSSKTAARKLKQMEEERLIERKIVPGGQLIKMTEKGIEILKNEYIEYSRIFSSEPDVLELEGNVLKGLGEGQYYINIPGYRNQFEEKLNFVPFPGTLNVQLSESSSALRNRLKEMPAVRIDGFNDGERTFGGGNCYPIKVEGIEAAVVVPDRTHYPADLIEIIAPVKLRDALKLKDGDRIVTRVKKQGMEGQK
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: BL1S5_PIG
Sequence: MSGGGTETPTGCEAPSGGGGGGGRKRDSLGTTSSPAHLIIKDLGEIHSRLLDHRPVIQGETRYFVKEFEEKRGLREMRALENLKNMIHETNEHTLPTCTETMEDSLSHVLQRLQAATASVCRLQQREQERKKVHNDHLIASEKQHIMQWEDFMKEQHSKQADVDEEHRKAMEKLKEQYAEMEKDLAKFSTF
What is the function of this protein?
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes.  In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.  The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension.  Plays a role in intracellular vesicle trafficking (By similarity).
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S5 family.
Protein: SSRP_SALCH
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANIGDSYVILKDGEAWLFGANFTPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRINREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDLKEREWQLDKARIMKNAGR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: DNAE2_XANOR
Sequence: MSWDDAIEGVDRDTPGGRMPRAWNVAARLRAANDDISHAHVADGVPTYAELHCLSDFSFLRGASSAEQLFARAQHCGYSALAITDECSLAGIVRGLEASRVTGVRLIVGSEFTLIDGTRFVLLVENAHGYPQVCGLVTTARRAASKGAYRLGRADVEAQFRDVAPGVFALWLPGVQPQAEQGAWLQQVFGERAFLAVELHREQDDGARLQVLQALAQQLGMTAVASGDVHMAQRRERIVQDTLTAIRHTLPLAECGAHLFRNGERHLRTRRALGNIYPDALLQAAVALAQRCTFDISKISYTYPRELVPEGHTPTSYLRQLTEAGIRKRWPGGITAKVREDIEKELALIALKKYEAFFLTVQDVVRFAREQNILCQGRGSSANSAVCYALGITAVNPDETRLLMARFLSEKRDEPPDIDVDFEHERREEVLQYVYRKYGRERAALAATVICYRGKSAVRDVAKAFGLPPDQIALLANCYGWGNGETPMEQRIEEAGFDLANPLINKILLVTEHLRDHPRHLSQHVGGFVISDEPLSLLVPVENAAMADRTIIQWDKDDLETMKLLKVDCLALGMLTCIRKTLDLVRGHRGRDYSIATLPGEDLPTYKMIQRADTVGVFQIESRAQMAMLPRLKPAEFYDLVIEVAIVRPGPIQGDMVHPYLRRRQGREDVSYPSPAVEDILKPTLGVPLFQEQVMELLMHAADYTESEADNLRRSMAAWRRGGDMEQHRMRVRERMQGKGYASTFIDQIFEQIKGFGSYGFPQSHAASFAKLVYASCWLKRHEPAAFACGLLNAQPMGFYSASQIVQDARRGSPERERVEVLPVDVVHSDWDNTLVGGRPWRSAADPGEQPAIRLGMRQVAGLSDVVAQRIVAARTQRAFADIGDLCLRAALDEKACLALAEAGALQGMVGNRNAARWAMAGVEARRPLLPGSPEERPVAFEAPHAGEEILADYRSVGLSLRQHPMALLRPQMRQRRILGLRDLQGRPHGSGVHVAGLVTQRQRPATAKGTIFVTLEDEHGMINVIVWSHLALRRRRALLESRLLAVRGRWERVDGVEHLIAGDLHDLSDLLGDMQLPSRDFH
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FH2_ORYSI
Sequence: MSSSARGITLLCLLLIVSSTVLHFSIGGGSNGEKRRDDGDGDGDDEKVRLLLGANALGERDRRHGHGHGGGVSSAPAPAPAPARAHLPPPLLHKNARLPDPVPGRVGLGHRRGNATAAHRRRSEREGKKSTPLVVVAAGAALSGAAAVLLVVLVVFLACRRFQRRAMPGADQSGTNKVSFDPGPDVFYLDAVKPYVEADHGGGGGVVKTAPELAGPKEEPRCEEEDSGVALSDDGADSVHSSCCFHSSHFSYSELRDTKPGSNGVSPSPSGRSRRRSSAPVTPSEKNKAASPYSPQCPRTPSNRERSSRAHSPSSSVSDLTSVSTSVVKDHEVRRAVHSLMFPEAQSGGAGHVKEDEAESGNMRPPPPPPPPPPPPPPAVTQQQDVKTSCGPAVPPPPPPTPPPPPPLLAPKQQSSGGPILPPAPAPPPLFRPWAPAVGKNGAPLPKLKPLHWDKVRAAPNRRMVWDRIRSSSFELDEKMIESLFGYNARCSTKHEEVQSRSPSLGHHVLDTKRLQNFTILMKAVSATAEQIFAALLHGNGLSAQQLEALIKMAPAKDEADKLSAYDGDVDGLVPAERLLKVVLTIPCAFARVEAMLYRETFADEVGHIRKSFEMLEEACRELMSSKLFLKLLEAVLKTGNRMNVGTARGGAMAFKLDALLKLADVKGTDGKTTLLHFVVQEMTRSRAAEAADIAAGLGAELTNVRKTATVDLDVLTTSVSGLSHGLSRIKELVGSDLSGDERNQCFVAFMAPFVAHAGEVIRELEDGERRVLAHVREITEYYHGDVGKDEASPLRIFVIVRDFLGMLERVCKEVRGAKNCHGGNPALNLNNV
What are the official names of this protein?
Formin-like protein 2, OsFH2.
What is the protein family that this protein belongs to?
Belongs to the formin-like family. Class-I subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MTA_CARCW
Sequence: MDPCDCAKTGPCNCGATCKCTNCQCTTCKKSCCSCCPSGCSKCASGCVCKGNSCGSSCCQ
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein A, MT-A.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: AROC_PELUB
Sequence: MSFNTFGKQFRFTTWGESHGPALGCVVDGCPPNINLKEQDIQVELDKRKPGQSKFTTQRKEDDKVQILSGVFEGKTTGTPISLIIYNQDMRSKDYGDIKDKFRPGHADFTYFKKYGIRDYRGGGRSSARETAARVAAGAIAKKVLENKLGKKFKVVGAVTQLGILGCDTRKWNDLTINKNPFFCPDKNMLKLWEKYLLDIRKSGSSCGAVIEVRARGIPVGLGAPIYSKLDMDIASAMMSINAVKGVNIGSGMNSAQLSGEQNSDEISQKGKKLKFDSNNAGGILGGISTGQEIVVSFAVKPTSSILTTRKTINKFGKNTTISVKGRHDPCVGIRAVPVGEAMMNCVLLDHYLMNKAQCS
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PORTL_BPPH2
Sequence: MARKRSNTYRSINEIQRQKRNRWFIHYLNYLQSLAYQLFEWENLPPTINPSFLEKSIHQFGYVGFYKDPVISYIACNGALSGQRDVYNQATVFRAASPVYQKEFKLYNYRDMKEEDMGVVIYNNDMAFPTTPTLELFAAELAELKEIISVNQNAQKTPVLIRANDNNQLSLKQVYNQYEGNAPVIFAHEALDSDSIEVFKTDAPYVVDKLNAQKNAVWNEMMTFLGIKNANLEKKERMVTDEVSSNDEQIESSGTVFLKSREEACEKINELYGLNVKVKFRYDIVEQMRRELQQIENVSRGTSDGETNE
What is the function of this protein?
Forms the portal vertex of the capsid (PubMed:10801350) (PubMed:19744688, PubMed:21570409).  This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection (By similarity).  The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel (PubMed:11812138, PubMed:21570409).  Binds to the 6 packaging RNA molecules (pRNA) forming a double-ring structure which in turn binds to the ATPase gp16 hexamer, forming the active DNA-translocating motor (PubMed:15886394, PubMed:11130079).  This complex is essential for the specificity of packaging from the left DNA end.
What are the official names of this protein?
Portal protein, Connector protein, Gene product 10, gp10, Gene product 19, gp19, Head-to-tail connector, Probable portal protein, Protein p10, Upper collar protein.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus portal protein family.
What are the subcellular locations of this protein?
Virion. Note=Present in 12 copies in the virion.
Protein: EIF3F_MOUSE
Sequence: MASPAVPANVPPATAAAAPAPVVTAAPASAPTPSTPAPTPAATPAASPAPVSSDPAVAAPAAPGQTPASAPAPAQTPAPSQPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPNPIHLTVDTGLQHGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL
What is the function of this protein?
Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit F, eIF3f, Deubiquitinating enzyme eIF3f, Eukaryotic translation initiation factor 3 subunit 5, eIF-3-epsilon, eIF3 p47.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit F family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIO5_DICDI
Sequence: MYKEPKNESEYEAELKNAPVAVVYLTATWCGPCRAIAPVFTNISNAPENSKITFFKVDVDALKKLPVCESLQGVPTFIAYRNGEEQERFSGANKVALENMVKKLL
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Putative thioredoxin-5, Trx-5.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: RL35_MANSM
Sequence: MPKIKTVRGAAKRFKKTASGGFKRKQSHLRHILTKKTTKRKRHLRHKSMVAKADQVLVVACLPYV
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: DEMA_MOUSE
Sequence: MERLQKQPLTSPGSVSSSRDSSVPGSPSSIVAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRECSLSPKSTSPPPSPEVWAESRTLGIISQASTPRTTGTPRTSLPHFHHPETTRPDSNIYKKPPIYKQRESVGGSPQSKHLIEDLIIESSKFPAAQPPDPNQPAKIETDYWPCPPSLAVVETEWRKRKASRKGAEEEEEEEDDDSEEEIKAIRERQKEELSKVTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPFHTSLHSGTSKSSSLPSYGRTTLSRLQSTEFSPSGSEAGSPGLQNGEGQRGRMDRGNSLPCVLEQKIYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF
What is the function of this protein?
Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization.  Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA).  Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane.  Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties.  Also plays a role as a modulator of actin dynamics in fibroblasts; acts as negative regulator of the RhoA activation pathway.  In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation.  Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration.  Acts as a tumor suppressor and inhibits malignant cell transformation.
What are the official names of this protein?
Dematin, Dematin actin-binding protein, Erythrocyte membrane protein band 4.9.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane. Membrane. Endomembrane system. Cell projection. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane (By similarity).
Protein: CCMA_NITEU
Sequence: MTTGPSPIEMLTARNLECIRGEHRLFSNLSFSVNPGELMFVGGPNGSGKTSLLRLLCGLSLPDDGEIYWNGTDIRKLGVDYRDVMTYLGHLGGIKDDLTAIENLRISCALAGCEIDEDQAADALGQIGLAGREMLPARVLSQGQRRRVALARLLVTRTKLWILDEPLTALDVAAVELIKGILEHNLAKGGMVIMTTHQELVMSTVTVHHLVLS
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CLPB_WOLSU
Sequence: MNAFEKMTHQLRETLEQALSLALHAKNPEVDLPHMAWALLINSTSILNQALNKMGVDKSALELEAKSLVDRLPQSSSLTKENIKISKRLADSLTQAEALGVKGGDKFIAVDTWLLANLKEEPLKSLFSKYLDVNELKKNLESIRGGAKIESATDDENLESLAKYGIDLTQKALENKLDPVIGRDEEISRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIIAKEVPLSLQNKRVVALDMSALIAGAKYRGEFEDRLKKVVEEVKKAGNVILFIDEIHTIVGAGASEGSMDAANILKPALARGELHTIGATTLKEYRKYFEKDAALQRRFQPIFLNEPTINEALQILRGIKERLEAHHNVTIYDSALVAAAKLSSRYITDRYLPDKAIDLIDEAAAELKMQIESEPTELSLIKRQIQRLEVEKEALLMEKESTHSEARIKEIQAELENAKERQRTLLAQFENEKAVFNEIASIKAKADELRRESELAKRSGDYNKAAEIDYGKIPELENREKELNTQWNRMQESGTLLKNAVSEESIAGIVSRWTQIPVKKMLQGEKEKVLGVEEELRKDVVGQDEALHAIARAIKRNKAGLSENNRPIGSFLFLGPTGVGKTQSAKTLAKFLFDSDKNLVRIDMSEYMEKHAASRLVGAPPGYVGYEEGGQLTEAIRRKPYSVVLFDEIEKAHPDVFNILLQVLDDGRLTDNKGVTVDFRNTIIILTSNIASDKIMENSDKERRESAVKAELKRYFKPEFLNRLDDIIIFNPLGLAQIVEIVEIMFEGIREKLKERQITLELTQSAKEQIAEVGFDPVYGARPLKRALYEEVEDRLAELILEDKISEGSHVVFDAQGGKIIARI
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_RHOCS
Sequence: MPSLKDIRNRIGSVKSTQKITSAMKMVAASKLRRAQEQAEAGRPFADRMARMLASLAANVSGATGGPRLMTGTGSDQVHLLVVVTSDRGLCGGFNSTIVREARRTIKRLTGEGRTVKLLCVGRKGRDLLRREYAGMIVHSFEDVGRRRLSFADADRITAKVLELFEAGEFDVATVIYNKFRSAITQVVTAQQVIPFAPAVATEPAETAEAKPLYEFEPNEEKILAELLPRNLAVQVYSALLESAASEQGARMTAMDNATRNAGDMIKKLTLVYNRTRQASITKELIEIISGAEAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PYRF_PROM4
Sequence: MTLVNPSEKLILALDGMDVLEALSFIDKVPDLIWVKVGLELFATSGLEIFTELRARGKKVFLDLKFHDIPNTMAGACYRAARNGAELITVHACAGSKALLVANEAAKKGAASVGLPSPTLLGVTVLTSWTSYEFGDELDIHHSLEKRVEHLAQLAFKAGLGGCICSPCEVKRLREIFPESFELITPGIRFLDSGLDDQARVMQPRDAFTSGASRLVLGRIITRSTNPAEAFTRVCRDIQTD
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: ZC3HF_MOUSE
Sequence: MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCRHFLEAIENNKYGWFWVCPGGGDNCMYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYIQGTGGDEVDDSMGVNDIDISLYVPRDVEETGITVASVERFSTYAPDKDENKLSEASGGLAENGERSDLDEDSGGGGQENGSIDAVPVDENLFTGEDLDELEEELNTLDLEE
What is the function of this protein?
Protects DRG1 from proteolytic degradation (PubMed:15676025).  Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity).
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 15, DRG family-regulatory protein 1, Epo-immediate response gene protein FM22.
What is the protein family that this protein belongs to?
Belongs to the ZC3H15/TMA46 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.