PharMolix/UniProtQA huggingface dataset:
Protein: RSSB_ECO57
Sequence: MTQPLVGKQILIVEDEQVFRSLLDSWFSSLGATTVLAADGVDALELLGGFTPDLMICDIAMPRMNGLKLLEHIRNRGDQTPVLVISATENMADIAKALRLGVEDVLLKPVKDLNRLREMVFACLYPSMFNSRVEEEERLFRDWDAMVDNPAAAAKLLQELQPPVQQVISHCRVNYRQLVAADKPGLVLDIAALSENDLAFYCLDVTRAGHNGVLAALLLRALFNGLLQEQLAHQNQRLPELGALLKQVNHLLRQANLPGQFPLLVGYYHRELKNLILVSAGLNATLNTGEHQVQISNGVPLGTLGNAYLNQLSQRCDAWQCQIWGTGGRLRLMLSAE
What is the function of this protein?
Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells.  Acts by binding and delivering RpoS to the ClpXP protease.  RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation.
What are the official names of this protein?
Regulator of RpoS.
What is the protein family that this protein belongs to?
Belongs to the RssB family.
Protein: SSRP_CUPNH
Sequence: MTIADNKKAFFDYFIEERYEAGIVLEGWEVKAIRAGRVQIKEGYVVVRDAEMFLIGAHISPLQSASTHVNPDPVRTRKLLLKADEIKKLIGKVEQRGYTLVPLNLHYTRGRVKCEIGLAKGKKQFDKRETEKQRDWQREKARIMKGDAKD
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: GPMA_LACP7
Sequence: MKLVLLRHGESEWNKENLFTGWMDVDLSETGKAEAASAGITLKQKGYDFDVCYTSYLKRAIHTLNLALDEMDRVWLPVVKSWKLNERHYGTLQGLNKSETAERYGEEQVKIWRRSYDIAPPLLKEEDERNPRFQEQYRQEKCEILPLGESLKDTIARVVPYYNEVILKDMMAGKRVLIAAHGNSLRALMKYLEDMSPEDILNVNLPTGIPLVYELDEEGKFISKEYLGDAEYVKAKIEKVSAQGKVTIE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: MURC_LEGPL
Sequence: MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVRSSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQLGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQRPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQGVGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDALSLSDELLLMDIYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSB_PEA
Sequence: MTDSFAHCASHINYRHKMKTMFIFSTPCCSPSTAFFSPFRASNSKPLRSTLSLRSSISSSSITSTSHCSLAFNIVKHKEKNVVSANMTSSVSSRTFLNAQNEQDVLSGIKKEVEAGTLPASIAAGMEEVYLNYKSAVIKSGDPKANEIVLSNMTALLDRIFLDVKEPFVFEAHHKAKREPFDYYMFGQNYIRPLVDFETSYVGNMPLFIQMEEQLKQGHNIILMSNHQSEADPAIIALLLEMRLPHIAENLIYVAGDRVITVPLCKPFSIGRNLICVYSKKHMLDNPELVDMKRKANTRSRKEMAMLLRSGSQIIWIAPSGGRDRPVANSGEWAPAPFDSSSVDNMRRLVDHSGPPGHIYPLAILCHDIMPPPLKVEKEIGEKRIISYHGTGISTAPEISFSNTTAACENPEKAKDAYTKALYDSVTEQYDVLKSAIHGKKGLQASTPVVSLSQPWK
What is the function of this protein?
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate.  The enzyme from chilling-resistant plants discriminates against non-fluid palmitic acid and selects oleic acid whereas the enzyme from sensitive plants accepts both fatty acids.  This is an oleate-selective acyltransferase.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, chloroplastic, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: KATG_HERSS
Sequence: MSNEAKCPFNHTAGSGTSNRDWWPKQLRVDLLAQHSSKSNPMGEDFDYAEAFKSLDLAAVKADLAKVMTDSQDWWPADFGHYGPLFVRMAWHSAGTYRIGDGRGGAGRGQQRFAPLNSWPDNVNLDKARRLLWPVKQKYGNKISWADLLILTGNVALETMGFKTFGFAGGRADVWEPDLDVYWGTESTWLGGDDRYGKGKGSSSQGEIPADAHRHGQEQARTAPAGRNLENPLAAVQMGLIYVNPEGPEGNPDPLAAAHDIRETFARMAMDDEETVALIAGGHTFGKTHGAGDAKHVGREPEGEDMDSQGLGWKSSFGSGVGGDTISSGLEVTWTQTPAQWSNYFFENLFKYEWELTKSPAGAHQWVAKGADAVIPHAHGGAPLLPTMLTTDLSLRFDPAYEKISRRFLEHPEQFADAFARAWFKLTHRDLGPRSRYLGPEVPAEELIWQDPLPQAEGAQIDAADVAALKAKVLGSGLSVPELVATAWASASTFRGGDMRGGANGARIRLAPQKDWAANQPAQLAKVLKTLEGIQSAFNQGGKKVSLADLIVLAGSAAVEKAAQDAGVAVAVPFRAGRVDASQEQTDAASFAPLEPIVDGFRNFQKQRYAVRGEDMLIDKAQQLTLSAPEMTVLVGGLRVLGNNVGGSTKGMFTDRVGVLSNDFFVNLLDMATEWKSTSPAQEEFEGRDRKTGAVKWAGTRVDLVFGSNAVLRALAEVYASADAKEKFVKDFVAAWVKVMELDRFDLK
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: RPOA_TOLAT
Sequence: MLGSVTDFLKPRLVDIEQLSPTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVAEVEIDGVLHEYSSKEGVQEDILEILLNLKGIAVKLEGKDEVILSLTKSGAGPVTAGDIIHGDDVVIVNPEHVICHLTGANAEISMRLRVQRGRGYVPASARLHTDDEDRPIGRLLLDAAFSPVVRIAYNVEAARVEQRTDLDKLVIDMETNGTLDPEEAIRRAATILAEQLDAFVDLRDVSVPEKKEDKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASLADN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RL23_MYCPA
Sequence: MATVTDPRDIILAPVISEKSYSLLDDNVYTFVVHPDSNKTQIKIAIEKIFSVKVASVNTANRQGKRKRTRTGFGKRKSTKRAIVTLAPGSKPIDLFGAPA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: SUE1_YEAST
Sequence: MILLKRTKIRGVSVSFVSLQRRTHSRLVNPIRQQHQQITKQRSSKILKNAHFYDFRSLPKVPTTQYLEARELTRDILYSGYRPVMYPVKENPLFRDKKRKSLQTLLTMNEKTNAEAKTIDEKKHKNILFGERGTGGIMSGGVNGTWKYNPTVPNELLPFNWWSTSSMGMEYFPEWKNVPPYMMRKLKPFDKALQMRLTHKSKKKMK
What is the function of this protein?
Required for degradation of unstable forms of cytochrome c.
What are the official names of this protein?
Protein SUE1, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion envelope.
Protein: NUOH_BRUSU
Sequence: MEGIFAAYVLPALIIALKSVVLLVVLLIVVAYLLYADRKIWAAVQLRRGPNVVGPWGLFQAFADLLKFVFKEPIIPSGANKGVFLLAPFISAVLAMATWAVIPVNEGWAVANINVGILYIFAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVIVTVLLTVGSLNLTDIVLSQNTGLGTMLGLPASFLDWNWLCLFPMFVVFFISALAETNRPPFDLVEAESELVAGHMIEYSSTPFLLFFLGEYVAITLMCALMTVLFLGGWLPPVDVWFLSWVPGIIWFMLKLCFCFFLFAMVKAFVPRYRYDQLMRLGWKVFLPISLFMVVATATFLKVFGLA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PNP_CERS1
Sequence: MFNVTKKSIEWGGETLTLETGKVARQADGSVIATLGETSVMANVTFAKAAKPGQDFFPLTVHYQERYYAAGKVPGGFFKREARPSEKETLTSRLIDRPIRPLFVDGFKNEVLLIVTVLSHDLVNEPDIVAMIAASAALTISGVPFMGPIGAARVGFAGGEYVLNPDVDDMQKLRENPEQRLDLVIAGTKDAVMMVESEAYELSEAEMLGAVKFGHEAMQPVIDMIIDFAEEAAHEPFDFSPPDYAALYAKVKSLGETQMRAAFAIREKQDRVNAIDAARAAIKAQLSEAELADENLGTAFKKLESSILRGDIINGGARIDGRDTKTVRPIISETSVLPRTHGSALFTRGETQALVVTTLGTGEDEQIIDALHGNSRSNFLLHYNFPPYSVGEVGRFGPPGRREIGHGKLAWRALQAVLPAATDFPYTIRVVSEITESNGSSSMASVCGGSLSMMDAGVPLKAPVAGVAMGLILEDDGKWAVLTDILGDEDHLGDMDFKVAGTENGITSLQMDIKVAGITPEIMEQALAQAKDGRMHILGEMSKALSSANSFSAYAPKIETLTIPTDKIREVIGSGGKVIREIVETSGAKVDINDDGVIKIASNDQAAIKKAYDMIWSIVAEPEEGQIYTGKVVKLVDFGAFVNFFGKRDGLVHVSQIANKRLTHPNEVLKEGQEVKVKLLGFDERGKVRLGMKMVDQETGQEIQPEKKEKEEAGEA
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAA_ACTPJ
Sequence: MQSIPIKNVGTDNISQLIDRFERQYVYLRLSITDVCNFRCNYCLPDGYKPPSHKQQFLSVSEIQRVVRAFADLGTEKVRITGGEPTLRKDFLEIAHTVSQTNGIKKVALTTNGYRMERDIDLWQQAGITDINVSVDSLDTRQFQLITGENKLQSILKGIDRAFEIGYRKIKVNAVLMKQYTAPELDKFLVWIKDKPIQMRFIELMETGEMDSFFQAQHLSGQSVMQRLLQEGWQLQPKALSDGPAKVLSHPDYQGEIGLIMPYEKNFCASCNRLRVSALGKLHLCLFGEEGIDLRDLLSEDTQQAQLEARLKAALQGKREHHYLHIGDSGIRNNLASIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: LIPL3_CAEEL
Sequence: MCSSLCALLLVILAVHNVHAKSDPELHMTTPQIIERWGYPAMIYSVTTDDGYILELHRIPHGKTNVTWPNGKQPVVFMQHGLLCASTDWTMNLPEQSAAFIFADAGFDVWLGNMRGNTYSMKHKNLKASHSDFWEWSWDEMATYDLPAMIDKVLEVTGQESLYYMGHSQGTLTMFSHLSKDDGIFAKKIKKFFALAPVGSVKDIKGFLSFFAHYFSLEFDGWFDVFGAGEFLPNNWAMKLAAKDICGGLKIESDLCDNVCFLIAGPESDQWNSTRVPVYASHDPAGTATQNIVHWIQMVRHGGVPAYDWGSKENKKKYGQANPPEYDFTAIKGTQIYLYWSDADWLADKTDITNYLLTRLNPAIIAQNNYFTDYNHFDFVFGLRAPNDIYLPIVDICTKDYNGK
What is the function of this protein?
Lipase that, together with lipl-1, plays a role in the response to nutrient deprivation by controlling lipid metabolism (PubMed:23604316).  Specifically, involved in the breakdown of lipids during lipophagy, a process during which lipids contained in lipid droplets that have been delivered to lysosomes by autophagy are degraded (PubMed:23604316).
What are the official names of this protein?
Lipase lipl-3, Lipase-like 3.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted. Lysosome lumen. Note=Secreted into the intestinal lumen.
Protein: M3K7_HUMAN
Sequence: MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
What is the function of this protein?
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Plays an important role in the cascades of cellular responses evoked by changes in the environment.  Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR).  Ceramides are also able to activate MAP3K7/TAK1.  Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7.  These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK).  Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK.  MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis.  In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B.  Promotes TRIM5 capsid-specific restriction activity.  Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.
Protein: SYNP2_RAT
Sequence: MGTGDFICISMTGGAPWGFRLQGGKEEKQPLQVAKIRSQSKASDSGLCVGDEVVSINGNPCADLTYPEVIKLMESITDSLHLLIKRPTSGTSEALDSETENTNHQHLPHGGPMESTTLQIQHAAKTQGKDFLLASVQTSAPRTEDQGNAWGYAECTTEDQVSQMPGSQEGHLVEEVILRKKPEAGQPGHVVELQLSLSKERQRCTSDPIVTLLGNEKFKSPDPDWGTQHGRTVHINSIPAPEKADTSLTSGTTVQTSSGRELTVIQGRDPGGTGLPQVEVILDCSDRLKAEECRLQAGRGCVASPVEGGRSEAPPSLVSFAVSSEGTEQGEDQRSGKDQGRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREEEEEDQEAGDKDEISDLAFLGTSESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKRLNRGDKMEMLPDTTGKGALMFAKRRERMEQFTAQNEEEKTGGLAGGGSDALQTDGLRTMTSYQRKEESVRMQSSVSESSFQMGRSLGSVPQQNGFSGVSETAGPQRMIPMNRTAKPFLGSVNQTAAPFSPTQSVTSPIPDFPAPPPYSAVSPPPEAFSRGISSPVAGPAQPPPWPQPAPWSQPAFYDSSEQIASRDERIAVPAKRTGILQEAKRRGTTKPMFTFKETKVSPNPELLSLLQNAEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSAKQKTPPPVAPKPAVKTSSSSQPVAPVSPVWSPGVAPAQGPAFSTTNPPNPPQVTAVSSIKIAQPTCPPARPASALNLAGPFKGPQAAVVSHNYTPKPSAPTPLVNAAPAGAGGPSNELPGMSGKGAQLFAKRQSRMEKYVVDSDTVQAHTVRAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAAIKSQPPGAQASKTSKKKGKKPLNTLDVMKHQPYQLNASLFTFQPPDSKDGLPQKSTVKVSSVAPAMKQALPPRQADIGSPTNAKASSVYSVPAYTSQPNFFAEATSPVSASPVPVSVPTSPKQETTSTSYFVAPRPKFSAKKSGVTVQENWRSLSLPGRAAPPIMSAPPWLCQPAYSYSSKPTLEQEKANKRPTPWEAAAKSPLGLVDEAFRPRNIEESIVANVVSAARRKVFAGSQEDWKERLSFVPQTQKTSMSFSERREYNVPSPVNSHVSSHSLYSSQLPYVCYRKESRNDLKAMSMDTRSEYCLPLGGYDYNPHPRGWRHQP
What is the function of this protein?
Has an actin-binding and actin-bundling activity.  Can induce the formation of F-actin networks.  At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines (By similarity).  Involved in autophagosome formation.  May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (PubMed:23434281).  Involved in regulation of cell migration.  May be a tumor suppressor (By similarity).
What are the official names of this protein?
Synaptopodin-2, Myopodin.
What is the protein family that this protein belongs to?
Belongs to the synaptopodin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell junction, focal adhesion. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. In undifferentiated myoblasts strongly expressed in the nucleus, after induction of myotube differentiation is located to both nucleus and cytoplasm along acting filaments, and in differentiated myotubes is located at the Z lines. Upon stress redistributes from cytoplasm of myoblasts and myotubes to the nucleus. Nuclear import is KPNA2-dependent and promoted by phosphorylation by PKA and/or CaMK2, and inhibition of calcineurin. The nuclear export is XPO1-dependent. Localized in a fiber-like pattern, partly overlapping with filamentous actin (By similarity).
Protein: RK5_SPIOL
Sequence: MASTSLLQSTSSSFAGVRFHCRTSAAPRVGLSSFTVKAAAGTAVFVDKAEAETINRLKTNYIEKMVPLLKEEFSYSNILEVPKVVKIVVNCGIGDASQNAKGLDAAINELALITGQRPVKTKAKTSIAGFKVREGMTLGIAVTLRGNLMYSFLDRLINLALPRTRDFQGVNPNSFDGHGNYSVGFREQSVFPEIKPEIVGKARGMDVCITTTAKTDKEAYKLLSLMGMPFREGSGPSTLVRKKKLKSHHFDAKKGRRY
What is the function of this protein?
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
What are the official names of this protein?
50S ribosomal protein L5, chloroplastic, Chloroplastic large ribosomal subunit protein uL5c.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RLMM_ECOLC
Sequence: MNKVVLLCRPGFEKECAAEITDKAGQREIFGFARVKENAGYVIYECYQPDDGDKLIRELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELLKFCRKFTVPLRAALRDAGVLANYETPKRPVVHVFFIAPGCCYTGYSYSNNNSPFYMGIPRLKFPADAPSRSTLKLEEAFHVFIPADEWDERLANGMWAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFKFRPTRSNISWMVCDMVEKPAKVAALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYIQAQLDEHGINAQIQARQLYHDREEVTVHVRRIWAAVGGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_CAUSK
Sequence: MTKLLLVAAGGALGSVARYLVGVQALRLFGSNWPYGTFIVNLTGGLLMGLLAAWLALRGGAQQEHWRVLLGVGVMGGFTTFSAFSLETALMIEKRAYAQAFTYTTASVILSVAAIFAGLLIARRIFSV
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FABZ_CAMC1
Sequence: MIDVVEIQKILPHRFPFLLIDRVVELEPAKNIVAYKNVTIGEPIFQGHFPGHPIYPGVMIIEGMAQAGGVLAFKSMSDEHQAGIENKVVYFMSIDGAKFRHPVRPGDRLEYRLNVLKHKGNIWVLEGKAYVDDVLCAEAELKAMIVDK
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_NITMU
Sequence: MALVKVKPTSPGRRAVVKVVNAGLHKGAPYPHLVEKQNRTAGRNNKGQITTRHIGGGHKQHYRIVDFRRNKDGIAARVERLEYDPNRSANLALLCYSDGERRYVIAPKGIVPGMQLMSGADAPIKNGNALPLRNIPVGSIIHCVEMMPGKGAQLARSAGASVQLLAREGDYAQLRLRSGEIRRVHVNCRATIGEVGNEEHNLRAIGKAGAQRWRGIRPTVRGVAMNPIDHPHGGGEGKTAAGRHPVSPWGTPSKGFRTRVNKRTDGMIVRRRYSNKG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: H33_PONAB
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLAREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes.  Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL22_PROM2
Sequence: MTKTSETTKIAIAHGNYIRGSASKVRRVLDQIRGRSYRDALIMLEFMPYRSTDPITKVLRSAVANAEHNLGMDPSTLIISSAWANSGPVMKRYRPRAQGRAFSIKKQTCHISISVESAPNKTNAEVQN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: YUFK_BACSU
Sequence: MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGMLDYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGSMIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLFWFTFVIGILFIFIKLYNSIMASLPV
What are the official names of this protein?
Uncharacterized membrane protein YufK.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.