PharMolix/UniProtQA huggingface dataset:
Protein: TOM70_HUMAN
Sequence: MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWSRQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL
What is the function of this protein?
Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792).  Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629).  Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199).  Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812).
What are the official names of this protein?
Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, Translocase of outer membrane 70 kDa subunit, Translocase of outer mitochondrial membrane protein 70.
What is the protein family that this protein belongs to?
Belongs to the Tom70 family.
Protein: ORF9_HAPV1
Sequence: MGGGGPPARVQGTEGSQTGGGAVAVSYHPNNLDTKPLSCLPILSNFLLISSNSSLTSSTSSPLLMSSRYASAVEIPSSSAYSSTNSIVASLSRIDTTSFELLMVSRLRSSTPGKPFCSVPSVA
What are the official names of this protein?
Uncharacterized protein 9.
Protein: RPOA_ELYCL
Sequence: MVREEVAGSTQTLQWKCVESRVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGEIEGTCITRAKFWSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRDASICVKGPRYITAQDIILPPSVEIVDTAQPIANLTEPIDFCIDLQIKRDRGYQTELRKNYQDGSYPIDAVSMPVRNVNYSIFSCGNGNEKHEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHAEEEGTSFEENKNRFTPPLFTFQKRLTNLKKNKKGIPLNCIFIDQLELTSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFHMEDRKHIWDTLEKHLPIDLLKNKLSF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NIKR_THESM
Sequence: MKIIRFGVSMPEDLLEKFDTIMEEKGYANRSEAIRDLVRDFIVRHEWEEGDKEVAGTITIVYNHDEADVVKELLDMQHDYVNEIISSLHVHMDEHNCLEVIVVKGKGSRVKTIAERLISLKGVKHGKLVMTTTGKELV
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: RS16_LEIXX
Sequence: MAVKIRLKRLGKIRAPHYRIVVADSRTKRDGRVIEEIGLYHPTEEPSRIEVDSDRAQYWLGVGSQPTEQVLVLLKLTGDWGTFKGDKNAVSTVKVAGAKEAFVADEKKKPVLKPKAAKPAEAEAVIEAEEAAEVEVVAEAGDIADEAADGEKA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: Y4FK_SINFN
Sequence: MQIDARHGSADKTSHQVMPLPFGKLVLCLLVAGTIAALIAVLLYPPLNPLALFSMLDWNLIAAAEPLVRQCGSLPLLDKFPSLGWNTVLFCATLPSTDEPLRTDSFVAHTRDTILANLGSVEPNWRWKVSSETPEACSLAYHRQRVLSAWLASAEHSVCLQALARRDTRLISFYFVLSGHIEITDRRTRKTLSISPNHVASARERAGNRMTIQSESSWLAFHIPESALRRSFEDLTGRPYVHEFVLPATCFSQDDVQGLYQTLRQAERDLNSAASKAMPLLAKAYKQLALVKLFSTMPHNLAEAFCQGTSGAAPRQLLKAEAFMRENLTNPVTIEDLAAAARCTPRALQRMFRTYRGGSPMSVLCNYRLAAAHGAIKAGRAGSITELALNLQFSNPGRFSVLYKSAYGLSPSSALRFTRNEGSVEQA
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator y4fK.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RIMM_CUPMC
Sequence: MTGNASGRKPLNLAATQGGASGRQKKLPAALLFTDTLPDDLVEVGYVGAAYGIRGWIKVQPHADDASALLHARRWWLLRAPPAGVVSAPAQSAEAVSIKISQSREHSGTVVAQPAGVSDRSVAEMLKGRRVWVRRADFPAAEEGEFYWVDLIGCAVVNEQGEALGEVTGLIDNGAHQILQVAYELPDGKAAERLIPFVDAFLRTVDTPARRIVVDWGLDY
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_BACAN
Sequence: MPKVTVYNQTGSQVGEIELAEAIFGIEPNEAVLFEAVMMQRASLRQGTHKVKTRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGTVFGPTPRSYAYKLPKKVRRLAIKSALATKVVENNIVVLEDLVLNAPKTKDMLAVLKGLTVEKKALIVTADANESVELSARNIPGVTVITADGVNVLDVLHHDKLIMTKAAVEKVEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: DNLI_METM6
Sequence: MLFIDFCKILDKIEKTTKRLEKTDYFVELIDFIKNNGKAENLKQVSQITIGRVFAEFENKEIGIGPNLLIEAVKTTGISEKDLKAEIKKTGDIGIAVENLSSNIKQVSLFSQPLTLEEIYSTLKKLSEIEGNSSQKKKTRIISNLLILSNPVESRYISRLILEDMRIGMNIPTILASFSNYFNVNKEAVEKIYAVTNDIGLIGKKLISGSDIENDSELKLKVFRPIKPMLAQLTPSIEDAIIETKMPQFETKYDGARVQVHKSNGKVNIYSRRLENITNSVPELVEEINKIDIDNIILEGECVAMDLSSGKPRPFQDILRRFRRKYDIDKVAEKIALRIYFFDVLYYEKGLIDTPLKNRREILEKLFGTNNWDSELEKIQKEIFSNKMLFSSFKLNSDDPDLAKEFFNWSLSIGHEGIMIKNPDAPYTPGSRVKTMYKVKPTLENLDVVVTRAKIGMGKRKDWYGSYEISVKDDEDNLHVIGNVGSGLTEDDLERLTTIVNEIKIEDLGEEVILEPKIVLEVTYEEIQTSEKYEMGYALRFPRVVQIREDKSINDINTLDDVKKIYEIERNRK
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: Y658_CHLPN
Sequence: MDISGAVKQKLLQFLGKQKKPELLATYLFYLEQALSLRPVVFVRDKIIFKTPEDAVRILEQDKKIWRETEIQISSEKPQVNENTKRIYICPFTGKVFADNVYANPQDAIYDWLSSCPQNMEKQGGVRIKRFLVSEDPDVIKEYAVPPKEPIIKTVFASAITGKLFHSLPPLLEDFISSYLRPMTLEEVQNQTKFQLESSFLSLLQDALVEDKIAAFIESLADDTAFHVYISQWVDTEE
What are the official names of this protein?
Protein CPn_0658/CP_0089/CPj0658/CpB0684.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0658/CT_538/TC_0825 family.
Protein: RL31B_RALPJ
Sequence: MKEGIHPNYREVVFQDMSSDFKFITRSTIQTKEMITLDGKEYPLAKIEVSSESHPFYTGQQKVLDTAGRVEKFRNKFGSKIGKAAK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: RL11_PSET1
Sequence: MAKKVEALIKLQVNAGMANPSPPVGPALGQHGVNIMEFCKAFNARTESIEKGAPVPVVISVYGDRSFTFDMKTPPAAYLLLKAAGVKSGSGRPNTEKVGTVTRAQLEEIVETKRADLTASDLEAAVRTIAGSARAMGLSVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: TRPF_CAUSK
Sequence: MVQAKICGLSTLDAVTAAVAGGAAFVGFVFFEKSPRNLDPEAAARLVASLRQSPVKTVAVTVDPDDALIDRLMATMKPDLIQVHGRETPSRVRQIAERSGAGVIKAFSVSSAADVDQAGAFDGLVEHLMFDARPVEGSVLPGGTGARFDWSLLQGRRFSRPHFLAGGLDPWNVAEAVKASGAPLVDVSSGVERGPGLKDPALITAFLDAVKRV
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: C_SEND6
Sequence: MASATLTAWIKMPSFLKKILKLRGRRQEDESRSRTLSDSSMLSCRVNQLTSEGTEAGSTTPSTLPKDQALLIEPKVRAKEKSQHRRPKIIDQVRRVESLGEQASQRQKHMLETLINKIYTGPLGEELVQTLYLRIWAMEETPESLKILQMREDIRDQVLKMKTERWLRTLIRGEKTKLKDFQKRYEEVHPYLMKEKVEQVIMEEAWSLAAHIVQE
What is the function of this protein?
The different products prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways.  They inhibit IFN-alpha/beta induced tyrosine phosphorylation of STAT1 and STAT2.  Blocking the IFN-alpha/beta pathway requires binding to STAT1 in the cytoplasm.  They inhibit IFN-gamma induced serine phosphorylation of STAT1.  Block the IFN-gamma pathway by binding to and stabilizing the parallel form of the STAT1 dimer, further inducing high-molecular-weight complex formation and inhibition of transcription by IFN-gamma.  May also have a role in preventing the cell to enter apoptosis.  Modulate regulation of viral transcription and replication.  Overexpression inhibits the viral RNA polymerase.  The absence of all C', C and Y2 proteins leads to viral delayed growth.  Plays an important role in virion particles release.  Modulates virion shape.
What are the official names of this protein?
Protein C'.
What is the protein family that this protein belongs to?
Belongs to the respirovirus protein C family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Protein C' seems to localize around the Golgi.
Protein: KGX43_CENEX
Sequence: DRDSCVDKSKCGKYGYYGQCDECCKKAGDRAGICEYYKCKCNP
What is the function of this protein?
Reversibly blocks Kv11/ERG potassium channels.
What are the official names of this protein?
Potassium channel toxin gamma-KTx 4.3, CexErgTx2, CexErg2, ErgTx2, Ergtoxin-like protein.
What is the protein family that this protein belongs to?
Belongs to the ergtoxin family. Gamma-KTx 4 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HSP1_MACGI
Sequence: MARYRHSRSRSRSRYRRRRRRRSRYRSRRRRYRGRRRRRSRRGRRRRGYSRRRYSRRRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SEML_HUMAN
Sequence: MYCQDSNICAVFAVQGGKVGRKHGIKRGRRPSIRSPAQRARGPWIHESKHPAFAKQQINLEMPNSRATTELAWVCSSTSRKKKWARSLTLSTAPLSPPPSLVHCEDCSCLPGCHSGDLYNLAPAERTC
What are the official names of this protein?
Putative protein SEM1, isoform 2.
Protein: UREG_ACIBY
Sequence: MTERSPLRVGIGGPVGSGKTALTLNLCRALRDKYNMAVVTNDIYTKEDSNFLTRNEAMSPDRIVGVETGGCPHTAIREDASINLAAIDDLCEKFDGLELIIIESGGDNLAATFSPELSDLTLYVIDVAGGEKIPRKGGPGITKSDLLIINKTDLAPMVGANLDVMDQDAKRMRGEKPFLFSNMKTQDGLEEIIQFIEKQGLFKA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_METKA
Sequence: MARMHSRDRGKSGSTRPPRVAPPSWVEYSPEEVESLVVDLAKQGYEPAMIGIKLRDEYGIPDVKLITGKKITEILEEHGLAPELPEDLLNLIRRAKRVREHLKRHPKDLHSKRGLQLIESKIHRLVKYYKRKGVLPEDWKYDPEALHVE
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: ATPE_CLOK1
Sequence: MAEVLKLTILTPDREFYKGEVLEVITDSIQGNITILPGHMPLITTLKSTDTRIVEKSGKELKAFTSNGILEIKNNELKILCDVCEWPGEIDLKRAEEAKKRAEQRLAHKDGIDVKRAQLALNRALARINLLK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MINC_CROS8
Sequence: MSNTPIELKGSSFTLSVVHLHDAHPEVIRKALEEKIAQAPAFLKNAPVVVNVAGLDGSINWQQLHQTFIDSGLHLVGISGCQDDALKAEISRAGLALLTEGKASAPRAAKPAETPAPPAAALRTRLIDLPVRSGQRIYAPGADLVVTSHVSAGAELIADGNIHVYGTMRGRALAGAGGDKEAQIFSTNLAAELVSIAGVYWLSDQIPAEFYNKAARLRLADGALTVQPLN
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: GRPE_LEPBP
Sequence: MAEETNQSLEDQNVQVEEGQTISDEAIEQAVEGAEKELDNAKKEIESLKDSWLRERAEFQNYKRRTANDLLNARKESIKKFAEGLTGALDNLERVSNVPNQTPEVVAFVEGIKMVQKEFYSVLEKEGIKRLDPKGQPFDPMLMEAIASEESAEFTEETVVETYQAGYYHEEGESKQSIRPARVKVGKPQS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNAA_BOVIN
Sequence: MDNSGKEAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGSAFCQAAHVHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAAQLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKRIKKLLEAHEEQNVDSYTEAVKEYDSISRLDQWLTTMLLRIKKTIQGDEEDLR
What is the function of this protein?
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (PubMed:8455721).  Together with GNA12 promotes CDH5 localization to plasma membrane (By similarity).
What are the official names of this protein?
Alpha-soluble NSF attachment protein, SNAP-alpha, N-ethylmaleimide-sensitive factor attachment protein alpha.
What is the protein family that this protein belongs to?
Belongs to the SNAP family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FARP1_PONAB
Sequence: MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLECPDHKKITVWLDLLKPLVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELYSEVLEQSQQSASLTFGEGAESPGGQSCQQGKEPKVSPGEPGSHPSPVPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSAVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAVHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRHMHYKQVLERLCKHHPPSHADFRDCRAALAGITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIKESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKNSSLAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSVAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPTESENIHKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRVHVSSHKESLVY
What is the function of this protein?
Functions as guanine nucleotide exchange factor for RAC1.  May play a role in semaphorin signaling.  Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).
What are the official names of this protein?
FERM, ARHGEF and pleckstrin domain-containing protein 1, FERM, RhoGEF and pleckstrin domain-containing protein 1.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Synapse. Synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine. Note=Recruited to the cell membrane via interaction with CADM1.
Protein: RQC2_YEAST
Sequence: MKQRISALDLLLLARELKQDLEGYRLSNIYNIADSSKQFLLKFNKPDSKLNVVVDCGLRIYLTEFSRPIPPTPSGFVVKLRKHLKAKRLTALKQVDQDRILVLQFADGHFYLVLEFFSAGNVILLDENRRIMALQRVVLEHENKVGQIYEMFDESLFTTNNESADESIEKNRKAEYTSELVNEWIKAVQAKYESDITVIKQLNIQGKEGAKKKKVKVPSIHKLLLSKVPHLSSDLLSKNLKVFNIDPSESCLNLLEETDSLAELLNSTQLEYNQLLTTTDRKGYILAKRNENYISEKDTADLEFIYDTFHPFKPYINGGDTDSSCIIEVEGPYNRTLDKFFSTIESSKYALRIQNQESQAQKKIDDARAENDRKIQALLDVQELNERKGHLIIENAPLIEEVKLAVQGLIDQQMDWNTIEKLIKSEQKKGNRIAQLLNLPLNLKQNKISVKLDLSSKELNTSSDEDNESEGNTTDSSSDSDSEDMESSKERSTKSMKRKSNEKINVTIDLGLSAYANATEYFNIKKTSAQKQKKVEKNVGKAMKNIEVKIDQQLKKKLKDSHSVLKKIRTPYFFEKYSWFISSEGFLVMMGKSPAETDQIYSKYIEDDDIYMSNSFNSHVWIKNPEKTEVPPNTLMQAGILCMSSSEAWSKKISSSPWWCFAKNVSKFDGSDNSILPEGAFRLKNENDQNHLPPAQLVMGFGFLWKVKTSGNEDNGDDDEEEEEEEEEEEEEEEEEEEEEEEEKEEEEKEEEQQQDEDDSNEVNGLEKGGDSNDSTKNNSFEHDNLEKDIEKHCTISSDTDSDSGNAKAKNDNSSTQRILDEPGVPISLIENINSNVRGKRGKLKKIQKKYADQDETERLLRLEALGTLKGIEKQQQRKKEEIMKREVREDRKNKREKQRRLQALKFTKKEKARVNYDKHKSELKPSLDKGDVVDDIIPVFAPWPALLKYKYKVKIQPGSAKKTKTLTEILHYFKSRPLDGSSTDNEMDWPQEHEMIKGLKEQDLVLLLCVDKLKVTIAGQKSTKNGGNSSKKGKKKR
What is the function of this protein?
As part of the ribosome quality control complex (RQC), a ribosome-associated complex, mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation.  Thereby, frees ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:23178123).  RQC2 is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety (PubMed:25349383).  RQC2 is important for the stable association of the E3 ubiquitin-protein ligase RKR1/LTN1 to the complex (PubMed:23479637).  RQC2 is also able to recruit alanine- and threonine-charged tRNA to the A site and directs the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal Ala and Thr extensions (CAT tails) (PubMed:25554787, PubMed:32934225).  CAT tails induce a HSF1-dependent heat shock response (PubMed:25554787).  CAT tails also promote the RKR1/LTN1-mediated ubiquitination of incompletely synthesized nascent polypeptides and their subsequent proteasomal degradation (PubMed:32934225).
What are the official names of this protein?
Ribosome quality control complex subunit 2, Translation-associated element 2.
What is the protein family that this protein belongs to?
Belongs to the NEMF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_STAS1
Sequence: MAKLQITLTRSVIGRPETQRKTVEALGLKKTNSSVVVEDNPAIRGQINKVSHLVTVEEK
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: CH60_CUPTR
Sequence: MAAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGIDKAVGAAVEELKKISKPTTTSKEIAQVGAISANSDASIGERIAEAMDKVGKEGVITVEDGKSLADELEVVEGMQFDRGYLSPYFINNPEKQVVALDNPFVLLFDKKISNIRDLLPVLEQVAKAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGTVIAEEVGLTLEKATLNDLGQAKRIEIGKENTIIIDGAGDAAGIEGRVKQIRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALLRARAAISALQGDNADQNAGIKIVLRAMEEPLRQIVLNAGEEASVVVAKVIEGKGNYGYNAASGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAETPKEESAPAMPGGMGGMGGMEGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CGT2_CAEEL
Sequence: MGDKITGLEVEIIPEISEVQPESLQEQNASSLYYPLFSQYIPLLLTGTKKILEDIDYCTCFAVFGVVFVSALYFLHIVGLCYGKYRLHRPTKPNPSLPGVSIIKPIIGADANLYTNLETFFTTQYHKFELLFCFDRSDDPAVKVVESLVKKYPSVDSTMFFGGEKIGLNPKINNMMPAYRIAKYQLIMISDSGIFMKSDAVLDMASTMMSHETMALVTQTPYCKDRKGFASVFEQIYFGTSHARIYLAGNCLQFNCPTGMSSMMKKEALDECGGFAAFSGYLAEDYFFGKKLASRGYKSGISTHPALQNSAAVTMTSFTDRVCRWVKLRMAMMPQIIFVEPLQDCFPSALIISFSLNYIANIDMLTTIMLHVVFWITMDCMVMCKMQNKKMSFSPLKFLLIWLLRELFAPLVFIKAALDPSIRWRDNVFHLAWGGKIRSQTSI
What is the function of this protein?
Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide to produce glucosylceramides (GlcCer).  GlcCer are known to contribute to the physical properties and physiological functions of membranes and may regulate signal transduction (PubMed:11443131, PubMed:19240113, PubMed:21325339).  Only branched-chain sphingoid bases like 15-methylhexadecasphing-4-enine are used for generating complex sphingolipids in Caenorhabditis elegans (PubMed:7651085).
What are the official names of this protein?
Ceramide glucosyltransferase 2, CGT-2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CLPS_CUPNH
Sequence: MATRLANVPQREAGTILERKEQALKPPAMFKVVLLNDDYTPMEFVVMILQQYFSRDRETATQIMLTVHREGKGVCGIYTRDIAATKVELVSTHARQAGHPLQCVMEEA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: MAZE9_MYCTU
Sequence: MKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Upon expression in E. coli and M. smegmatis neutralizes the effect of cognate toxin MazF9.
What are the official names of this protein?
Antitoxin MazE9.
Protein: PSD_NEIMB
Sequence: MNRLYPHPIIAREGWPIIGGGLALSLLVSICCGWWSLPFWVFTVFALQFFRDPAREIPLNPEAVLSPVDGRIVVVERARDPYRDVDALKISIFMNVFNVHSQKSPADCTVTKVVYNKGKFVNADLDKASTENERNAVLATTASGREITFVQVAGLVARRILCYTQAGAKLSRGERYGFIRFGSRVDMYLPVDAQAQVAIGDKVTGVSTVLARLPLTAPQTESEPESEPALQTAPVETAANPSAEQRQIEAAAAKIQAAVQDVLKD
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.