PharMolix/UniProtQA huggingface dataset:
Protein: SSRP_MYCSS
Sequence: MAAKKAGKAGATKDRNNQVVASNRRARHNYAILDTYEAGIALMGTEVKSLRDGQASLADAFATVDDGEIWLRNLHIPEYQHGSWTNHAPRRNRKLLLHRREIDNLIGKIRDGNLTLVPLSLYFTGGKVKVELALARGKQAHDKRQDLARRDAEREVVRELGRRAKGMS
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PHL2_BACCE
Sequence: MKGKLLKGVLSLGVGLGALYSGTSAQAEASTNQNDTLKVMTHNVYMLSTNLYPNWGQTERADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNYSSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENNNDSEYASMFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSYIENKVLQPKSPQWTVTSWFQKYTYNDYSDDYPVEATISMK
What is the function of this protein?
Required, with sphingomyelinase, to effect target cell lysis (hemolysis).
What are the official names of this protein?
Sphingomyelinase C, SMase, Cereolysin B, SMPLC, Sphingomyelin phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the neutral sphingomyelinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: MILT_DROME
Sequence: MTHVNNGEVMEKEMEPTGERERDRETAAGSGVHHRFLASASERDANSGNALEAAATKTKTGTTITNLEDLAFEACQNWSDLHQDFFITDDELEYEDELSLGSSIGGNIATTTTADAAVEGLITGEHQNEQLLMEVLCGNRVSQMTRAYDDIEAVTRLLEEKEKDLELTVQIGKELLTQNNALEARVADLETDLKASNDDRAQLVHELHKKNELISVLTNDADDGTDTDTPTMSKSITLDLLQRKVNSLLDENKSLKCEATQLAHQTDEVEEHERQLMADISAQLNDANSQYDNLSLELERQREENRLQHEQIVNLTARLAEAEMRLHQLTQDNDEHLSLLHVTKENQNALALELVEFKQRYEEVLALLHSAQDQLKQQRKRSQPQARSSFLGGLGTSGAGMGGSLFPPDSLHCELMESSLYSENSLDSGISGDSQRSADRISRMMMHMPSGGMSSSTMGGSVYAGAGNVPPYKRVFDTVRCAGKSGNYMDSGNVSMTQLGAMSMSSSSGPRMASMAYPAGSYYRGGSNQSLGVKTLSSESLNSQSDDGYPAQPSGVPGAPGAKELEAALKRLTPAEVLARRAMLSYAPAGTYNYDEPMGHGTGNVRNSDLPLGVRTPDSIMSTGSSGMSGSTNHMSASMTHQWRLPEKLQIIKPMEGSQTLHHWSRLATPTLSGLLDERPGVTIRGGRGLDDLGMQIYTLSDVEEDVSDDLPGKQFEAPGCTFTYTNSMVMHPDDGFVNDLSFLSQSQMSSRMASTSTSRQPSCPATPRAGLSRKNSCSTFSVNLGLAGMLNERGIKAVTPSALNTPAGPNFSPTVTPCNSPEGSPPRAQSPEPLFGLLSCGADLIRRKIVGDQHQQQQQKQRSSLSKQQQQKIMLSHLERRALRSLNLIEKVESIGLENIISAQRGLGSGIANRSSSPLSSGSLQSLHTSSNSIVDDIHFDRAQIKGVLHRGLKSPTPATASTSAAAAASGPGISTSSSTSAYNSDDSDDQGLVMKIKPSKSATPTTTGAAQSQPSSATTSNGTASETRLKQMQRQKSRRQLKNGMANQRPDLGTISGAGGGGRVRPDLGKVADSGSSSKLSTKRSEAKPAEEEEATPQTITQAFVGSVSSLLFGRKGGWL
What is the function of this protein?
Required for kinesin-mediated axonal transport of mitochondria to nerve terminals (PubMed:12495622, PubMed:16887820, PubMed:16717129).  The oocyte acquires the majority of its mitochondria by competitive bidirectional transport along microtubules mediated by the Milton adapter.  Mitochondria enter the young oocyte en mass from interconnected germ cells to generate the large aggregate known as the Balbiani body (PubMed:16887820).  Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria (PubMed:16717129).
What are the official names of this protein?
Trafficking kinesin-binding protein milt, Protein milton.
What is the protein family that this protein belongs to?
Belongs to the milton family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HXC6_MOUSE
Sequence: MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAVAQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-C6, Homeobox protein Hox-3.3, Homeobox protein Hox-6.1.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PXPA_STAA3
Sequence: MRVDLNCDLGEAFGNYSFGGDHQIIPLITSANVACGFHAGDENVMNETVKLAKAHNVAVGAHPGLPDLKGFGRRNIDISNDEIYNLMIYQLGALQGFCRIHQVKINHVKPHGALYQMGAKDREIANVIAQAVYDFDPSLVLVGLANSYLISEAKNVGLITASEVFADRRYEDDGQLVSRKESDAVITDTDEALKQVLKMVKENKVISKNNKEVTLQADTICVHGDGEHALLFVSKIREILMKEGIDIQSL
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: NU6M_ALBTU
Sequence: MMSLSFMLGLIFPVFFMFTLANPMSLLLLLLIMSLCAVLWLGSIMSSWFAYILFIVYIGGILVLFIYVCMISSNYITGLYKYKTLLYVGMVVALMS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: MCM2_YEAST
Sequence: MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPDIDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERDRLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREELTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELKNNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIYTLGH
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity; specifically the MCM2-MCM5 association is proposed to be reversible and to mediate a open ring conformation which may facilitate DNA loading.  Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity.  Necessary for cell growth.
What are the official names of this protein?
DNA replication licensing factor MCM2, Minichromosome maintenance protein 2.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MFA2_PORG3
Sequence: MNKRKHMDIRRLIISLPAIMALWGGLASCDKMIYDNYDDCPRGVYVNFYSQTECAENPSYPAEVARLNVYAFDKDGILRSANVFEDVQLSAAKEWLIPLEKDGLYTIFAWGNIDDHYNIGEIKIGETTKQQVLMRLKQDGKWATNIDGTTLWYATSPVVELKNMEDGADQYIHTRANLREYTNRVTVSVDSLPHPENYEIKLASSNGSYRFDGTVAKADSTYYPGETKVVGDSTCRAFFTTLKLESGHENTLSVTHKPTGREIFRTDLVGAILSSQYAQNINLRCINDFDIRLVAHHCNCPDDTYVVVQIWINGWLIHSYEIEL
What is the function of this protein?
Anchoring subunit of the minor fimbriae.  Regulates fimbrial length (PubMed:19589838).  These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome.  Fimbriae of P. gingivalis are major virulence factors (Probable).
What are the official names of this protein?
Minor fimbrium anchoring subunit Mfa2, Minor fimbrial antigen 2.
What is the protein family that this protein belongs to?
Belongs to the bacteroidetes fimbrillin superfamily. FimB/Mfa2 family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: PTH_BUCBP
Sequence: MKEIKLIVGLANPIKKYNDTRHNVGSWLVNSLVTQQNKKLKKNNKFLGYSTEINILSKNIHVLVPDTFMNLSGISVLAISNFYNIKLHEILVVHDELDLKPGNVKFRLRSSHNGHNGIRNVLAVLGTNIKFLRIQIGIGRPINSGYKISKFVLSKPNVSEKLLINRAILCAIRVIYDSINQRNVIMTESSLNSMLDHYMNSCVIHHN
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAD1_YARLI
Sequence: MSRVSMFPTEDKRSYFERQRDQYIKNISASMEDVLNNLNALNRSLEHTVGLSQKSEELAEMWSHFYNTVNEDLVKTEDGDIEVDTTKE
What is the function of this protein?
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
What are the official names of this protein?
DASH complex subunit DAD1, Outer kinetochore protein DAD1.
What is the protein family that this protein belongs to?
Belongs to the DASH complex DAD1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Protein: EF3_SCHPO
Sequence: MSAKSENKQSVKALEELLKHLTVCDAAEEADAAKALASFVNGPIEEQDAPSQVFSAISKQLNDKNATARERVLKGLEAVANHGSVAADVEPYLVELLPAVIAKVADKQNAVRDAAIAASKAIVRCTTPYAVKAIVPSVLESIHTTGKWNEKMNSLQLLDVLVEVAPSQLSYSLPQIIPVVSESMWDTKAEVKKQSKETMTKVCTLIANADIDRFIPELINCIAHPEEVPETIHSLGATTFVTEVQAPTLSIMVPLLARGLNERSTPIKRKTAVIIDNMSKLVEDPQVVAPFLPKLLPGLYHIKDTIGDPECRSVVQRAITTLERVGNVVDGKIPEVSTAANPEVCLETLKAVLGEIKVPTNEEVIAKYVANIAAQLVEEKDNENESWVLNITPYLTAFIDEAHIHKIVEQLRTRSIAKIPGGASHAEEEEEGEDLCNCEFSLAYGAKILLNRTRLRLKRGRRYGLCGPNGSGKSTLMRAIVNGQVEGFPTHLRTVYVEHDIDESEADTPSVDFILQDPAVPIKDRDEIVKALKENSFTDELINMPIGSLSGGWKMKLALTRAMFKNPDILLLDEPTNHLDVVNVAWLENFLVNQKDVSSIIVSHDSGFLDHVVQAIIHYERFKLRKYLGNMSEFVKKVPSAKSYYELGASEMEFKFPEPGFLEGVKTKQRAIIKVQHMSFQYPGTSKPQLNDISFQVSLSSRIAVIGPNGAGKSTLIKVLTGELLPTVGEIYQHENCRIAYVAQAAFTHLGHHPDKTPSEYIQWRFQSGEDLEAMDKASRVISEADEEAMKNKIFKIEGTQRKILGIHSRRKLKNSYEYECSFLVGENIGMKSERWVPMMSSDNAWLPRGELMETHAKMVAEVDRAEALKSGQFRPLVRKEIEEHCSLLGLDAELVSHSRIKGLSGGQKVKLVLAACTWLRPHVIVLDEPTNYLDRDSLGALSKGLKNFGGGVVLVTHSREFTEGLTEEVWAVNNGHMTPSGHNWVSGQGSGPRIQEKEEGDTFDAFGNKIEKAKKAKKLTGAELRKKKKERMARRKAGLEVSDDEL
What is the function of this protein?
Ribosome-dependent ATPase that functions in cytoplasmic translation elongation (PubMed:29300771).  Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity).  Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity).
What are the official names of this protein?
Elongation factor 3, EF-3.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_LIMF3
Sequence: MKVIFTEDVKGRGKRGEIKNVPDGYAQNFLIPRGKAKEANKAAMSELAGQERSREKHEAEELAAAKELKKVLEDDKTVVELTGKAGTDGRMFGSVSTKQIATALEKQYQIKLDKRKMELAAPIRALGYVNVPVKLHHDVEATLRVHIAEK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RL33_AQUAE
Sequence: MAREIITLACTECKRRNYTTTKNKQKHPERLELRKYCKWCRKHTIHREVK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: MATK_PARAU
Sequence: MEEFQAYLELDRSRQHDFLYPLIFREYIYALAYDHGLNSSILLENLGYENKYSLLIVKRLITRMYQQNHLIISANDSNKNPFWGYNKNLYSQIISEGFAVSVEIPFSLQLISSLEEAEIIRSYNLRSIHSIFPFFEEKFPYLNYVSDVRIPYPIHLEILVQTLRYWVKDASFFHLLRLFLYEYCNWNSLITQKKWISTFSKRNPRFFLFLYNFYVCEYESIFLFLRNKSSYLRLTSSGVLFERIYFYAKIEHFVEVFDKDFPSTLWFFKDPFIHYVRYQGKSILASKNTPFLMKKWKYYLIHLWQCHFFVWSQPGKIHINQLSEHSFYFLGYFSNVRLNPSVVRSQMLENSFIIENVMKKLDTIIPIIPIIRSLAKARFCNVLGHPISKPVWADSSDFDIIDRFLLICKNLSHYYNGSSKKKNLYRIKYILRLSCIKTLARKHKSTVRVFLKRLGSELLEEFFTEEEEILSLIFPRASSTFQRLYRGRIWYLDIFYFHQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YIDD_PSEAE
Sequence: MKFLLIGLIRFYQYAISPLIGPRCRFYPSCSHYTLEAIRVHGALRGGYLGARRLLRCHPWHPGGYDPVPERQEQACACHRTAKPGK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PYRC_ECODH
Sequence: MTAPSQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSIDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVKQ
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: RS18_PSEF5
Sequence: MARFFRRRKFCRFTAEDVKEIDYKDLNTLKAYVSETGKIVPSRITGTKARYQRQLATAIKRARFLALLAYTDSHGR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: LNT_PSESM
Sequence: MRWITRPGWPGNLLALAAGGLTTLALAPFDFWPLVLVSVAMFYLGLRELSPRQALARGWCYGFGLYGAGTSWIYVSIHTYGGASALLAGLLMLLFIAAIALFFALPAWVWARWLRRNEAPLADSLAFAALWLWQEAFRGWFLTGFPWLYSGYSQLDAPLAGLAPVGGVWLISFALGLTAALLCNLHRLRARKSFLAMGVLLLLAPWVAGLALKDHAWTSPSGPPLKVAAMQGNIEQSMKWDPQKLNDQLALYRDMTFRSQQADLIVWPETAVPVLKESAEGYLSMMGKFAADRGAALITGVPVREPTGRGEYSYYNGITVTGQGDGTYFKQKLVPFGEYVPLQDLLRGLISFFDLPMSDFARGPNDQALLQAKGYHIAPFICYEVVYPEFAAGLSAQSDLLLTVSNDTWFGTSIGPLQHLQMAQMRALEAGRWMIRATNNGVTALIDPFGRITVQIPQFERGVLYGEVVPMHELTPYLHWRSWPLAIVCLLLFGWALLAARISKTV
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDXS_HAEDU
Sequence: MSVILGSDLVKRGMAQMQKGGVIMDVVNAEQARIAEAAGAVAVMALERVPSDIRAAGGVARMANPRIVKEVMEAVSIPVMAKARIGHITEARVLEAMGVDYIDESEVLTPADEEFHLLKSEYTVPFVCGCRDLGEALRRIGEGASMLRTKGEPGTGNIVEAVRHMRKVNSQVRKVVNMSTDELMTEAKILGAPFELLLQIKQLGKLPVVNFAAGGVATPADAALMMELGADGVFVGSGIFKAENPEKFARAIVQATTHYQDYDLIARLSEELGEPMRGLEISKLSVQDRMQERGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: PNP_STRAT
Sequence: MENETHYAEAVIDNGAFGTRTIRFETGRLAKQAAGSAVAYLDDDTMVLSATTASKNPKDQLDFFPLTVDVEERMYAAGKIPGSFFRREGRPSEDAILTCRLIDRPLRPSFKKGLRNEIQVVATIMALNPDHLYDVVAINAASASTQLAGLPFSGPYGGVRVALIRGQWVAFPTHTELEDAVFDMVVAGRVLEDGDVAIMMVEAEATEKTVQLVKDGAEAPTEEVVAAGLDAAKPFIKVLCKAQADLAAKAAKPTGEFPVPSSTTRTTSEALSAAVRPELSAALTIAGKQDREAELDRVKALAAEKLLPEFEGREKEISAAYRPWPSSSSAERVIKEKKRIDGRGVTDIRTLAAEVEAIPRVHGSALFERGETQILGVTTLNMLRMEQQLDTLSPVTRKPYMHNYNFPPISVGETGRVGSPKRREIGHGALAERAIVPVLPTREEFPYAIRQVSEALGSNGSTSMGSVCASTMSLLNAGVPLKAPVAGIAMGLISQEINGETHYVALTDILGAEDAFGDMDFKVAGTKEFVTALQLDTKLDGIPASVLAAALKQARDARLHILDVMMEAIDTPDEMSPNAPRIITVKIPVDKIGEVIGPKRQMINQIQEDTGAEITIEDDGTIYIGAADGPAAEAARATINGIANPTSPEVGERILGSVVKTTTFGAFVSLLPGKDGLLHISQIRKLAGGKRVENVEDVLGVGQKVQVEIAEIDSRGKLSLIPVIEGEEAASDEKKDDAEQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCPB_STRPF
Sequence: MTYLSQIEALLFVAGEEGLSLRHLASMLSLTPTALQQQLEKLSQKYEKDQHSSLCLIETANTYRLVTKEGFAELLRAYAKTPMNQSLSRASLEVLSIVAYKQPITRIEIDDIRGVNSSGALSKLLAFDLIREAGKKDVVGRPHLYATTDYFLDYMGINHLDELIEVSAVEPADEEIALFRTQD
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: BASI_RAT
Sequence: MAAALLLALAFTFLSGQGACAAAGFLKAPMSQEQWAGGSVVLHCEAVGSPMPEIQWWFEGNEPNDSCSQLWDGARLDRVHIHATYRQHAASTLSVDGLAAEDTGTYECRASSDPDRNHLTRPPRVKWVRAQASVVVLEPGTIVTSVQEVDSKTQLTCFLNSSGIDIVGHRWMRGGKVLQEDTLPDLQMKYTVDADDRSGEYSCIFLPEPVGRGNINVEGPPRIKVGKKSEHASEGEFVKLICKSEASHPPVDEWVWFKTSDTGDQTISNGTEANSKYVIISTPELSELIISDLDMNVDPGTYVCNATNSQGSARETISLRVRSRLAALWPFLGIVAEVLVLVTIIFIYEKRRKPDQTLDEDDPGAAPLKGSGSHLNDKDKNVRQRNAT
What is the function of this protein?
Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity).  Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1 and SLC16A3 to the plasma membrane (PubMed:10921872).  Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity).  Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity).  Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (By similarity).
What are the official names of this protein?
Basigin, Glycoprotein CE9, OX-47 antigen.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein.
Protein: ATPG_STAAC
Sequence: MASLKEIDTRIKSTKKMKQITKAMNMVSSSKLRRAEKNTKQFTPYMDKMQDAITAVAGASSNTNHPMLRPRKITRSGYLVITSDKGLAGAYSANVLKKLITDIEAKHQDSSEYSIVVLGQQGVDFLKNRGYDIEYSQVDVPDQPSFKSVQALANHAIDLYSEEEIDELNIYYSHYVSVLENKPTSRQVLPLSQEDSSKGHGHLSSYEFEPDKESILSVILPQYVESLIYGTILDAKASEHATRMTAMKNATDNATELIDDLSLEYNRARQAEITQQITEIVGGSAALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: THIL_MACFA
Sequence: MAVLAALLRGGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLSLLPTTKLGSIAMQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPARQAVLGAGLPISTPRTTINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNRGSTPYGGVKLEDLIVKDGLTDVYNKIHMGSCAENTAKKLNIARDEQDAYAINSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTITAANASTLNDGAAALVLMTAGAAKRLNVTPLARIVAFADAAVEPIDFPIAPVHAVSMVLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEIDPQKVNINGGAVSLGHPIGMSGARIVGHLTHALKQGEYGLASICNGGGGASAMLIQKL
What is the function of this protein?
This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA.  Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms.  The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA.  Thereby, it plays a major role in ketone body metabolism.
What are the official names of this protein?
Acetyl-CoA acetyltransferase, mitochondrial, Acetoacetyl-CoA thiolase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Mitochondrion.