PharMolix/UniProtQA huggingface dataset:
Protein: AAEA_YERPB
Sequence: MSTFSLKIIRVGITVLVVVLAVIAIFNVWAFYTESPWTRDAKFTADVVAIAPDVSGLLTEVPVKDNQLVQKGQILFVIDQPRYQQALAEAEADVAYYQTLAAEKQRESSRRHRLGIQALSQEEIDQASNVLQTVQHQLAKAIAVRDLARLDLERTTVRAPAEGWVTNLNVHAGEFINRGATAVALVKKDTFYILAYLEETKLEGVKPGYRAEITPLGSNRILHGTVDSISAGVTNSSSSADSKGLATIDNNLEWVRLAQRVPVKIHLDSEDQQYLYPAGTTATVVITGPNDRDPHQASPMTKLMHRLREFG
What is the function of this protein?
Forms an efflux pump with AaeB.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeA, pHBA efflux pump protein A.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LIPA_MYCTA
Sequence: MSVAAEGRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYTELKNLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAELDRDEPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATVRAIKELNPSTGVELLIPDFNGEPTRLAEVFESGPEVLAHNVETVPRIFKRIRPAFTYRRSLGVLTAARDAGLVTKSNLILGLGETSDEVRTALGDLRDAGCDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGFAGVLAGPLVRSSYRAGRLYEQARNSRALASR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_BRUO2
Sequence: MSNNTDLSPVHVIGGGLAGSEAAWQIAQAGVPVVLHEMRPVRGTDAHKTEQLAELVCSNSFRSDDAETNAVGVLHAEMRLAGSLIMACADAHQVPAGGALAVDREGFSQAVTARLEAHPLITIEREEITGLPPTEWGTTIIATGPLTAPSLAEAIAAETDADALAFFDAIAPIIHFDSINMDVCWFQSRYDKVGPGGTGKDYINCPMDKEQYEAFVAALIEGDKTDFKEWEGTPYFDGCLPIEVMAERGPETLRHGPMKPMGLTNAHNPTVKPYAVVQLRQDNALGTLYNMVGFQTKLKYGSQTGIFKMIPGLENAEFARLGGLHRNTYLNSPVLLDNVLRLKSRQTLRFAGQVTGCEGYVESSAIGLLAGRFTAAEKLSQAAVPPPPTTAFGALLGHITGGHIVTDDEPGKRSFQPMNVNFGLFPPVDVPKPEGKRLRGKEKTIAKKRALSARALADCRNWLSLY
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRDX6_HUMAN
Sequence: MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:9497358, PubMed:10893423).  Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423).  Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860).  These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423).  Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423).  Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860).  Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860).
What are the official names of this protein?
Peroxiredoxin-6, 1-Cys peroxiredoxin, 1-Cys PRX, 24 kDa protein, Acidic calcium-independent phospholipase A2, aiPLA2, Antioxidant protein 2, Glutathione-dependent peroxiredoxin, Liver 2D page spot 40, Lysophosphatidylcholine acyltransferase 5, LPC acyltransferase 5, LPCAT-5, Lyso-PC acyltransferase 5, Non-selenium glutathione peroxidase, NSGPx, Red blood cells page spot 12.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome. Note=Also found in lung secretory organelles (lamellar bodies).
Protein: EIF3L_DROGR
Sequence: MYGGEDFNNTQQDFYDDYAHTGDPALDLEYERNYYANRMPENVKYFLINFCQAIKEGNLYDIQNMYENTFPQISDHHFDKSAWPEEQEVGAIVDNDKVFLILYKELYYRHIHARIPGGPKLDQRINSFFNYCDFFNLIISAQNPVLLELPDIWLWELVDEFVYQFQNFAQYRARLTDKSQDEIQQLCVNHSNVWSILCILNVLHSLVDISNIKKQLEAISQGIDPQTVAGDFGKLAFYKMLGYFSLVGLLRVHSLLGDYYQAIKVLEPIEIHKKSAYSHIPACQISTSYYVGFAYMMMRRYADAIRTFSDILLYIQRTKQLYSTRSYQNDQINKQAEQMYHLLAICLVLHPQCIDESIQQVLREKNYHDAMFKMQCGDLEVFKSFFVFACPRFVSPCPPVADAPLEDYVKDPMEHQLLVFMDEVRQQKDLPTTRSYLKLYTTLPLTKLASFIDPNANEDDVSKLLIRLLCFKHKMRNLVWSKGPSGLEGTFKSGSELDFYIDDDMIHIADTKVSHRYGDFFVRKIMKFNDLNRKLKNINI
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit L, eIF3l.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARC_SANKS
Sequence: MTSSDLTQRKGLTMSDSTPDTPRSTPEDAARRLAVLSAQNERLAQVLGEARGKIVELQQQIEEFAKPPGTFAVFLAEHGDGTLDVMSAGRKMHVGASPSVDLTQLRPGQEVSLNEAFVVVAAGGFEPVGEIVTVKELLDDGRALVVGRSDEERVVRLAGSLAGAPLRAGDALTVDTRSGFVYERIPKAEVEDLVLEEVPDIDYGDIGGLGPQIEQIRDAVELPFNHPDLFREHGLRPPKGILLYGPPGCGKTLIAKAVANSLAAAVARRAAAAAEAGGTVDGSPVLVETANQAKSYFLNVKGPELLNKYVGETERHIRLIFSRAREKASQGYPVVVFFDEMESLFRTRGTGLSSDVETTIVPQLLSEIDGVERLDNVIVIGASNREDMIDPAILRPGRLDVKIKIERPDPEGAREIFAKYLTTDLPIHADDLAEHQGDTAAVVDGMIQRVVERMYADTEENQFLEVTYASGDKETLYFKDFNSGAMIQNIVDRAKKSAIKDFLATGQRGIRVEHLVTACVDEFKENEDLPNTTNPDDWARISGKKGERIVFIRTIVQDKNGSGRSAAGRTIETATSTGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Proteasomal ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: NLPD_SALTI
Sequence: MSAGSPKFTVSRIAALSLVSLWLAGCTSSSNPPAPVTSVDSGSSSNTNSGMLITPPPKMGATPQQAPQIQPVQRPVTQPMQTQPVTEQPVQMENGRIVYNRQYGNIPKGSYTGGSTYTVKKGDTLFYIAWITGNDFRDLAQRNSISAPYSLNVGQTLQVGNASGTPITGGNAITQADAAQQGVVTRSAQNSTVAVASQPTITYSEGSGEQSANKMLPNNKPAGTVVTAPVTAPTVSTTEPNASSTSTSAPISAWRWPTDGKVIENFGASEGGNKGIDIAGSKGQAIVATADGRVVYAGNALRGYGNLIIIKHNDDYLSAYAHNDTMLVREQQEVKAGQKIATMGSTGTSSTRLHFEIRYKGKSVNPLRYLPQR
What is the function of this protein?
Activator of the cell wall hydrolase AmiC.  Required for septal murein cleavage and daughter cell separation during cell division (By similarity).
What are the official names of this protein?
Murein hydrolase activator NlpD.
What is the protein family that this protein belongs to?
Belongs to the E.coli NlpD/Haemophilus LppB family.
What are the subcellular locations of this protein?
Cell inner membrane; Lipid-anchor. Note=Localizes at the septal ring.
Protein: SECA_BARQU
Sequence: MVGLGVFARKFFGSAYERRLKALRQKVAQINALEEQFQKLNDTQLCQKTDEFRKRLTEGETVDLLLPEAFATVREAAKRVYDMRPFDVQLIGGMVLHNCGIAEMRTGEGKTLMATLPIYLNALEGKGVHVVTVNDYLARRDAETMGKIFSFLGLTTGVILHDLDSDARRSAYACDITYATNNELGFDYLRDNMAFDRSQMVQRGHHYAIVDEVDSILIDEARTPLIISGPLEDRTDFYNLIDTFIPSLTPEDYEIDEKQKTITFTEVGTEKIEKMLEQAGHLKGKSLYDIENVAIIHHINNALKAHKLFVRDKDYIVRNNEIVIIDEFTGRMMPGRRYSEGLHQALEAKEHVAIQPENQTLASITFQNYFRMYRKLSGMTGTATTEAEEFSNIYDLEVVEIPTNLPIQRRDEDDEIYRTAEEKYRAIVRDIRQAHEKGQPILVGTTSIEKSEQLAERLRKEGITDFRVLNARYHEQEAYIIAQAGVPGALTIATNMAGRGTDIQLGGNVEMRIRQELQDMPEGIERTAKIEEIKKDVKQLKEKALAAGGFYVIATERHESRRIDNQLRGRSGRQGDPGRSKFFLSLQDDLMRIFGSNRMDGMLQKLGLKENEAITHPWINKALEKAQKKVEARNFEIRKNLLKYDDVMNDQRKVIFEQRMEIMNADDLIEMILEMRNEVIEDLVETYIPSETYSEKWDVKALQEEIHHLFNLELPVEEWAKEDGIAEEQILERISNAVTKLENERAERYSPEILAYFHKAVLLETIDTLWREHLVNLDHLRSVVGFRGYAQRDPLNEYKTESFELFQAMLRNLRRIVTSKLMRFEIIQQPTESLIPEQVDGNDSALNDQRKGNDSPLWMQIQENRVVVNPKDRNPKDSTTWGKVGRNERCPCGSEKKYKHCHGAFV
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: OPSD_CRIGR
Sequence: MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVICKPMSNFRFGENHAIMGVVFTWIMALACAAPPLVGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVILMVVFFLICWFPYAGVAFYIFTHQGSNFGPIFMTLPAFFAKSSSIYNPVIYIMMNKQFRNCMLTTLCCGKNILGDDEASATASKTETSQVAPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  Required for photoreceptor cell viability after birth (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: NS1_I77AF
Sequence: MDSNTVSSFQVDCFLWHVRKRFADQEMGDAPFLDRIRRDQKSLKGRSITLGIDIEAATRAGKLIIERILDEESDEALKMNIASVPASRYVTDMTPEEMSRDWFMLMPKQKFAGPLCIRMDQAILDKNIVLKANFSVAFDRLETLILLRAFTSEGAIVGEISQLPSLPGHTSEDVKNAIGILIGGLEWNDNTVRVSETLQRFAWGSSNENGRPPFAPKQERKMAGTVESEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: ILVD_THESQ
Sequence: MRSDVIKKGLERAPHRSLLKALGITDDEMRRPFIGIVSSWNEIIPGHVHLDKVVEAVKAGVRMAGGVPFVFPTIGICDGIAMDHRGMKFSLPSRELIADSIEIVASGFPFDGLVFVPNCDKITPGMMMAMGRLNIPSVLISGGPMLAGRYNGRDIDLITVFEAVGGYKVGKVDEETLKAIEDLACPGAGSCAGLFTANTMNSLAEALGIAPRGNGTVPAVHAKRLRMAKEAGILVVELVKRDIKPRDIVTLDSFMNAVMVDLATGGSTNTVLHLKAIAESFGIDFDIKLFDELSRKIPHICNISPVGPYHIQDLDDAGGIYAVMKRLQENGLLKEDVMTIYLRKIGDLVREAKILNEDVIRPFDNPYHKEGGLGILFGNLAPEGAVAKLSGVPEKMMHHVGPAVVFEDGEEATKAILSGKIKKGDVVVIRYEGPKGGPGMREMLSPTSAIVGMGLAEDVALITDGRFSGGSHGAVIGHVSPEAAEGGPIGIVKDGDLIEIDFEKRTLNLLISDEEFERRMKEFTPLVKEVDSDYLRRYAFFVQSASKGATFRKP
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: HEM3_SYNFM
Sequence: MTDRVIRIGTRGSMLALKQSGNVKAAMEALWPGLRVELQVVRTTGDKILDVPLAKVGGKGLFVKEIEDALLARTVDLAVHSMKDVPAILPEGLEIGAIPKREDPRDVIVTRTGKGIADLPMGGRVGTSSLRRASQIRKLRPDIEIANLRGNIETRLRKLTEGAFDAIILAAAGLHRMGWQNRVTSYLDPADFLPAIGQGAIGIELRCDDGEVRELLAPLHDPDTHVAVEAERSLLRTLEGGCQVPIGGHAHLVDGTLTLSGMVASIDGEELFRASRAGSPAQARKIGRDVGMELLDSGARRILEEIYRA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: NOLC1_HUMAN
Sequence: MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSIKFDSE
What is the function of this protein?
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832).  Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).  Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786).  It has intrinsic GTPase and ATPase activities (PubMed:9016786).
What are the official names of this protein?
Nucleolar and coiled-body phosphoprotein 1, 140 kDa nucleolar phosphoprotein, Nopp140, Hepatitis C virus NS5A-transactivated protein 13, HCV NS5A-transactivated protein 13, Nucleolar 130 kDa protein, Nucleolar phosphoprotein p130.
What is the protein family that this protein belongs to?
Belongs to the NOLC1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase.
Protein: HTT5_ARATH
Sequence: MALPPYDPNFTLAFSYGRRDNVFENDPEHDESASAAIVAVELISSARLALKLDSVRTEYSAQYLVDKAGSRNLRRRRKLTVKDCLNFALKKGGIPRAEDWPPLGSESKTPSSYEPALVSMKGEVIEPKDMDEVPELLVHQSAVGAKLHVFTPHIELQQDAIYLPRQVSMRATLDLEMG
What is the function of this protein?
Mediates both basal and acquired thermotolerance.  Involved in the mechanisms necessary for quick response to heat and subsequent heritable transgenerational memory of heat acclimation (global warming) such as early flowering and attenuated immunity; this process includes epigenetic regulation as well as post-transcriptional gene silencing (PTGS) (PubMed:30778176).  In response to heat, HSFA2 is activated and promotes the expression of REF6 which in turn derepresses HSFA2, thus establishing an heritable feedback loop able to trigger SGIP1 and subsequent SGIP1-mediated SGS3 degradation; this prevents the biosynthesis of trans-acting siRNA (tasiRNA) and leads to the release of HTT5, which drives early flowering but attenuates immunity (PubMed:30778176).
What are the official names of this protein?
Protein HEAT-INDUCED TAS1 TARGET 5.
What is the protein family that this protein belongs to?
Belongs to the heat induced plant HTT protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CD054_MOUSE
Sequence: MLSVHFWQTPVRPTDAASSLANGIQTPTHRRCQTSNWTGQLSSRTLATIAARAAAPWLQTTSAASFGSPPTSLWLAEAPPQGLKNWAVVATVAVVPTALGPAQARGNLFQATLWPLRDQRGTQDSPSAHHCLILSLKPGQGLRMEGGTSDMNSQTSLTPAEDPVSRPQDSPEPRQQLRPLPEPSASTLPEAKYVETCASAGLRRESPQTLKLPPEQQASRSPKTKAQDEPSGHAPEAPAPGESPASSQCLPSQACENDFSSSSSSSSSLVDSAEDNGLSKMDDPTKLLGVLATSSSSLGFESDPETSCRQHREEAGDRAGAGEDKRGGVDDGIASCKDIIAKSHSKRGPLRNEDAHYITTHEIQLTEVEQGMDFDVGLASRWDFEDNNVIYSFVDYASFGGSDETPGDITTEEDDDNSCYVSTTPSTNTTRTPSPISSDLARPGAGSSGRDTSSTEVGSGPSDSDTVPPPTGPGTATPPEPLLELREAALGASATAASSCGSAASQILLSIKPTSRAINEPSNVRAKQNIIYAAKHEGDMSLRVSSAAEHNSSSLKQNSAAAVAQDHAKKFIAVPARLQTRCGAIRAKELVDYASGASSAVSELDDADKEVRNLTSRAFRSLAYPYFEALNISSRESSTTLSEVGFGRWSTFLDLKCGGVGARVEQSLLRSSAASVAAGLRKGGGTRATADQLYLQTKKSQTKALEFVVSKVEGEIKHVETPLCFQKQVQTGSRVVTLLEPLNLRSESKASSATGPCRITKGSSKGPGSVYTDDGSETSESSKPASRSDGPQKKSKFASSLLKNVISKKMQREHEFKMERGEVTDTSHRNPPSTKETEGPPGAEKPWERGLQRQSSRHSEASSEYTVVSVSDAGGEGSVVGSKSPIFKASTPRESHTGSGQNVSDGHTEVCEIKKSASETVKGIFLRSQNSAFRTWKEKEAEKLEEKAPVGRLKLRKGGDWRADLGEISASKSTIMSRLFVPNIQQTPKDKQPEKQATKYPAAAAQATSVAVIRPKAPEIKIRLGSVQQPSSDFNIAKLLTPKLASGSSSKLFKTIEDNSRTQQKLFRGGDNLEKVPQFQVRDVRDKSKASGPLHQVRDVRKLIKGSGDSSDKGSVTPEQGLTGPKPRQLTPASGGSRSLSPMVIMCQAVANPREEGVDREPREGVSQVSNGGRLLNSSPEGTVLVHRASGRLPVATIAPNKSEQGSYLPVLKIVSKASAQRTPEKPKEEEAKEEGKAPKPARNALEKLTAAVRSMEELYSFNRNEWKRKSDPLPMMADSHVLSLIASEEKEGVAGPEGGDPDKLAKQLGQVEERDTGHKGGVVLRAAPIERLQRRNSNPSTESVSARAAAFENMARERPRSLYIPPVHKDVERTQPLQPLPPLPGNRNVFTVSSSSTQKTGGVAGKFPQGPSPEGLSTAKGIKAQGLRSLKISPATRAPPEDASNRKTAVSLEKSNSDCENYLTIPLKGSAASAELLGRPGASRDGPPSSSAATLCSLPPLSARSQVPSNPKGSQVSGTSRPAWRTKPDNHRETVVAAPTGPQSPEHTPTAVYHQQALPFTLQGAQPQVLCFSPPGMPAPAPAGPAAVPTDPFQQPQPQQTQRKMLLDVTTGQYYLVDTPVQPMTRRLFDPETGQYVDVPMTSQQQPVAPMSLPVPPLALSPGAYGPTYMIYPGFLPTVLPPNALQPTPMAHTPGGSELSVATEPPSKETAAAFTEAPYFMASSQSPASSSSSAPAATPQLVGAKGFAQLHGKPVISITSQPLGPRIIAPPSFDGTTMSFVVEHR
What are the official names of this protein?
Uncharacterized protein C4orf54 homolog.
Protein: ERA_XANCP
Sequence: MSETSPHRSGSVAVIGRPNVGKSTLTNALVGAKVSIVSNRPQTTRHRLLGIATFPEGQLMLVDTPGLHREQKRAMNRVMNRAARGSLEGVDAAVLVIEAGRWDEEDTLAFRVLSDADVPVVLVVNKVDRLKDKTALFPFLAQVSEGRTFAAVHPVSALKRKGLEALVSDLLKLVPEAEAMYGEDEITDRSQRFLAGELVREQLMRQLGEELPYATTVEIERFAEDGALLRIGAVIWVEREGQKAIVIGKGGTRLKDIGGKARLQMERLFGAKVFLETWVRVREGWSDDEAALKAFGYD
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: HTPX_SALTY
Sequence: MMRIALFLLTNLAVMVVFGLVLSLTGIQSSSVQGLLIMALLFGFGGSFISLLMSKWMALKSVGGEVIEQPRNERERWLMNTVATQARQAGIAMPQVAIYHAPDINAFATGARRDASLVAVSTGLLQNMSPDEAEAVIAHEISHIANGDMVTMTLIQGVVNTFVIFISRIIAQIAAGFLGGNRDEGEGSNGNPLIYFAVATVLELVFGILASIITMWFSRYREFHADAGSAKLVGREKMIAALQRLKTSYEPQEATSMMAFCINGKSKSLSELFMTHPPLDKRIEALRSGEYLK
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BGL30_ARATH
Sequence: MAKGSWFFIILFIISMLENMINSLELDRHSFPDDFIFGTAASAFQYEGATSEGGKSPTIWDHFSLTYPERTKMHNADVAIDFYHRYKDDIKLMKELNMDAFRFSISWSRLIPSGKLKDGVNKEGVQFYKDLIDELLANDIQPSMTLYHWDHPQSLEDEYGGFLSPKIVEDFRDFARICFEEFGDKVKMWTTINEPYIMTVAGYDQGNKAAGRCSKWVNEKCQAGDSSTEPYIVSHHTLLAHAAAVEEFRKCEKTSHDGQIGIVLSPRWFEPYHSDSTDDKEAAERALAFEIGWHLDPVIHGDYPEIVKKYAGNKLPSFTVEQSKMLQNSSDFVGINYYTARFAAHLPHIDPEKPRFKTDHHVEWKLTNHSGHIIGPGEERGFLFSHPEGLRKVLNYIKERYNNMPVYIKENGINDNDDGTKPREEIVKDTFRIEYHKTHFEELHKAIVEDGCDVRGYYAWSLMDNFEWEHGYTARFGLYYVDFVNGLKRYPKDSVKWFKRFLKKSVVGESNKEEVEEMSRAEGNKTFKGFEESAGFFASFMAMNQSRRDEENNRCSFDFPHTHFGVLQGIENPSSFY
What are the official names of this protein?
Beta-glucosidase 30, AtBGLU30, Protein DARK INDUCIBLE 2, Protein SENESCENCE-RELATED GENE 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: RAPA_SHESA
Sequence: MPFALGQRWISDTESELGLGTVVQVEGRMVTVLFPATGENRMFSRNEAPLTRVIYNPGDTVESHEGWSLSVEELTEKDGLVVYHGIHSETGEKVSLRETLLNHNIRFNKPQDRLFAGQIDRLDRFGIRYQCQLLRHQLATSDLLGLQGPRVGLIPHQMWIAHEVGRRYAPRVLLADEVGLGKTIEAGLIIHQQLLTGRAERVLIIVPDTLRHQWLVEMLRRFNLRFSVFDEDRCVEAFADHDNPFYTEQLVICSLELLRKKKRLDQALDADWDLLVVDEAHHLEWTEEAPSRAYQVVEALSEVVPGVLLLTATPDQLGHESHFARLRLLDPDRFYDYDAFLAEENSYKDVAVAAEALAGDAKLSDAAINSLTELLSEKDIAPSIRLIQAEDIDSELQQAARSELLQELLDRHGTGRVLYRNSRASVKGFPKRIFNAYPHAMPEQYLTAARVNEMMGGRKSLEAQAAQALSPEKLYQEFEDNSASWWKFDPRVDWLIEFLKSHRSKKVLIIASGADTALSLEEALRTREGIQATVFHEGMSIIERDKAGAYFAQEEGGAQALICSEIGSEGRNFQFASHLVLFDLPLNPDLLEQRIGRLDRIGQKNDIQIHLPYLQDTAQERLLNWYHQGLNAFELTCPSGHVLYSEFAEDLLNVLVGGDEDELTNLLNHTQSRYKELKHAMEQGRDKLLEINSHGGDKAKAIVERLAQSDQDTKLIGSVIRLWDIIGVDQEDKGENSIILRPSEHMMFPTYPGLHEDGVTVTFDRDTALSRDDIALITQEHPLVQTGLDLITGSDTGTTSVAILKNKALPAGTLFLELIYMADASAPKSSQLYRYLPPTPIRVLLDKNGNDLSAKVDYTSFDKQLSAVNRHIGSKLVTASQPILHPLFAKGEEYAQTAVNELVAQAREKMTSQLTGELDRLESLKAVNPNIREEELEYLRNQMQELSTYLDASQLQLDAIRMVLVSHV
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.