PharMolix/UniProtQA huggingface dataset:
Protein: YCAD_SHIDS
Sequence: MSTYTRPVMLLLSGLLLLTLAIAVLNTLVPLWLAQEHMSTWQVGVVSSSYFTGNLVGTLLTGYVIKRIGFNRSYYLASFIFAAGCAGLGLMIGFWSWLAWRFVAGVGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYVGTFLGQLLVSKVSTELMSVLPWVTGLTLAGILPLLFTRVLNQQAENHDSTSITSMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLNHKGVSNASIGFWMAVLVSAGILGQWPIGRLADKFGRLLVLRVQVFVVILGSIAMLSQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFTAMLMQNFSDNLLFIMIASVSFIYLLMLLRNAGHTPKPVAHV
What are the official names of this protein?
Uncharacterized MFS-type transporter YcaD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NADR_ECOLI
Sequence: MSSFDYLKTAIKQQGCTLQQVADASGMTKGYLSQLLNAKIKSPSAQKLEALHRFLGLEFPRQKKTIGVVFGKFYPLHTGHIYLIQRACSQVDELHIIMGFDDTRDRALFEDSAMSQQPTVPDRLRWLLQTFKYQKNIRIHAFNEEGMEPYPHGWDVWSNGIKKFMAEKGIQPDLIYTSEEADAPQYMEHLGIETVLVDPKRTFMSISGAQIRENPFRYWEYIPTEVKPFFVRTVAILGGESSGKSTLVNKLANIFNTTSAWEYGRDYVFSHLGGDEIALQYSDYDKIALGHAQYIDFAVKYANKVAFIDTDFVTTQAFCKKYEGREHPFVQALIDEYRFDLVILLENNTPWVADGLRSLGSSVDRKEFQNLLVEMLEENNIEFVRVEEEDYDSRFLRCVELVREMMGEQR
What is the function of this protein?
This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase.  The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner.  As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes.  The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide.  The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD(+).  The NMN adenylyltransferase domain also functions as the NAD and ATP sensor.
What are the official names of this protein?
Trifunctional NAD biosynthesis/regulator protein NadR.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the bacterial RNK family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm.
Protein: LEG2_APLLA
Sequence: DHIDLEFDVGQCIQASYTAPTTGRTSVNIVASDGTVVLHVDYRKHWGGNPSTGKPWQNILIINSKLGGSWGTEEKVHDVETTIVNYDYTQCGQDADFSLELNQKDIATYAYRSPVNTVSRVQFDDQGYDAVLRKLCVVYPAPSK
What is the function of this protein?
Lectin that binds beta-galactoside and a wide array of complex carbohydrates.
What are the official names of this protein?
Galectin b, Gal-b, Aplysina lactuca lectin b, ALL-b, Beta-galactoside-binding lectin b.
Protein: WDR20_HUMAN
Sequence: MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRPGKVVSFNP
What is the function of this protein?
Regulator of deubiquitinating complexes.  Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336).  Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336).
What are the official names of this protein?
WD repeat-containing protein 20, Protein DMR.
Protein: CA1A_CONEP
Sequence: MFTVFLLVVLATTVVSFTSDRASDSRKDAASGLIALTIKGCCSDPRCNMNNPDYCG
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.  This native peptide blocks mammalian nicotinic acetylcholine receptors composed of alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-3-beta-4/CHRNA3-CHRNB4 subunits (PubMed:9624161).
What are the official names of this protein?
Alpha-conotoxin EpI.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HCE1_ORYLA
Sequence: MNLAPSTCLLLLFLLDIAQALPVWDEEGHEEGHEEGDGDDFVDITTRILTSNNNTDQLLLEGDLVAPTNRNAMKCWSSSCFWKKASNGLVVIPYVISSEYSGGEVATIEGAMRAFNGKTCIRFVRRTNEYDFISVVSKTGCYSELGRKGGQQELSINRGGCMYSGIIQHELNHALGFQHEQTRSDRDSYVRINWENIIPASAYNFNKHDTNNLNTPYDYSSIMHYGRDAFSIAYGRDSITPIPNPNVPIGQRNGMSRWDITRINVLYNCR
What is the function of this protein?
Participates in the breakdown of the egg envelope, which is derived from the egg extracellular matrix, at the time of hatching.  Thus allowing the newly hatched fish to swim free.  HCE binds tightly to the egg envelope while it exerts the choriolytic swelling action.
What are the official names of this protein?
High choriolytic enzyme 1, Choriolysin H 1, HCE23, Hatching enzyme zinc-protease subunit HCE 1.
What are the subcellular locations of this protein?
Zymogen granule. Note=Stored as proenzymes in the zymogen granules.
Protein: VPX_LDVC
Sequence: MGGLEFCDQTSWYQIFIAFSLTYTPIAIYSLKVFRGTLAGIVNIFIFINCCVSFVYLMYHHSVTNTIALSLGAVIALVWGIYTLVKIVDWLVIRCRLCFLGRSYILAPPSHVDTSDGRQSLTTSLTTAFVVRKPGSTLVNGQLVPDFQRLVLGGKKAVSKGAVNLLKYVSK
What are the official names of this protein?
Protein X, Envelope protein, VpX.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein.
Protein: NO12A_MEDSA
Sequence: MASFLLSILVFFLSALVLVPQGFAEYYLNPAYRPPQTEPPVHKPPHKEPPVHKPPHKDPPVNKPPQKEPPVHKPPRKEPPTHRHPPSEDNIHF
What is the function of this protein?
Involved in the infection process during the plant-rhizobium interaction.
What are the official names of this protein?
Early nodulin-12A, N-12A, Early nodulin-NMS-8.
What is the protein family that this protein belongs to?
Belongs to the plant proline-rich protein superfamily. ENOD12 family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: SDCS_STAAN
Sequence: MAYFNQHQSMISKRYLTFFSKSKKKKPFSAGQLIGLILGPLLFLLTLLFFHPQDLPWKGVYVLAITLWIATWWITEAIPIAATSLLPIVLLPLGHILTPEQVSSEYGNDIIFLFLGGFILAIAMERWNLHTRVALTIINLIGASTSKILLGFMVATGFLSMFVSNTAAVMIMIPIGLAIIKEAHDLQEANTNQTSIQKFEKSLVLAIGYAGTIGGLGTLIGTPPLIILKGQYMQHFGHEISFAKWMIVGIPTVIVLLGITWLYLRYVAFRHDLKYLPGGQTLIKQKLDELGKMKYEEKVVQTIFVLASLLWITREFLLKKWEVTSSVADGTIAIFISILLFIIPAKNTEKHRRIIDWEVAKELPWGVLILFGGGLALAKGISESGLAKWLGEQLKSLNGVSPILIVIVITIFVLFLTEVTSNTATATMILPILATLSVAVGVHPLLLMAPAAMAANCAYMLPVGTPPNAIIFGSGKISIKQMASVGFWVNLISAIIIILVVYYVMPIVLGIDINQPLPLK
What is the function of this protein?
Mediates the transport of the dicarboxylates fumarate, malate, and succinate across the cytoplasmic membrane via a Na(+)-electrochemical gradient.
What are the official names of this protein?
Sodium-dependent dicarboxylate transporter SdcS, Na(+)/dicarboxylate symporter.
What is the protein family that this protein belongs to?
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PTPH4_MDBVW
Sequence: MEINKFICSQGPKKNSCEDFWRMVLEQESCIIVSLTETDDEDQVCYEYWVKEEDYELAFGRYVVKTLEIIEESSFTRTRLRLTDVSSDTSREIHHFWYPHWSDYGNPTNPAEILNLISKVNQKRKEMKKTADSQPGPIVVHCSAGIGRTGTFCTIDNALSQLRKEQTVCLPQTVLKIQKSKI
What are the official names of this protein?
Probable tyrosine phosphatase protein H4, PTP-H4.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
Protein: PPNP_GEOSM
Sequence: MSEFNNVSVVKEANIYFDGKVTSRTVIFPDGSRKTLGVMLPGEYTFNTGSAELMEILSGEMTVVLPGSPDPVAIKGGEAFEVPENASFKVNVTAVSDYICSFL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: COX2_NOCFA
Sequence: MCGDQEGVSVAHKASEEIGARPVRGRQGRILRRAGLAVSLGITAMLVSGCSIDNVWLRFGWPSGVTPQATRMRELWTWSIIAALAMGVLVWGLTFWTVVFHRKKKDSPEFPRQTGYNVPLELTYTAIPFVIIAVLFYFTVVVQNYVHEKVADPDVTVDVTAFQWNWKFGYREVDFKDGGYQFNGIDTAREEAAQAQLKEYEERVDTEHGHPQPGPVHGKPENDILSYLHYDTVETVGTSTEIPVLVLPTGKVIEFQLAAADVIHAFWVPEFLFKRDVMPNPKENHSDNVFQITEIEKEGAFVGRCAEMCGTYHSMMNFEVRAVSPEKFTRYLDERRAGKTNAEALAAIGESPVATSTRPFNTDRTVKSAAAPEAE
What is the function of this protein?
Subunits I and II form the functional core of the enzyme complex.  Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).
What are the official names of this protein?
Probable cytochrome c oxidase subunit 2, Cytochrome aa3 subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OSB7_DICDI
Sequence: MEADPSLVSYADQHGEWETREISIFGVVKSFISQLSIGQELTKVSMPSIFLMPYSILELAASRHLKYIHLLISAQHEEDPLKRMAIIIQYFFSCVRDGNFQKKPYNALLGEVHKCFVKYPSYDGQSTSTAQFIGEQVTHHPPLTAFNITTSEGITLDCNVQFSAKFHMNSVSVVTTGAVKICIPVKVGNQIIKETYIIDKGLPDALVKNVIFGTRSIYWTDSVDIMCEDSKTSATVHFDKNEYVKGEVSVYNTELEVEEHRASLKGYISDVVNIDYLESKSSEAAPASSASKKEKKKEKKKAKHSKHTCSPSDTILMDTKQLEPNSTLYPKQTDPITSLGTWKEVTKQIVAGDMQAADQIKKEIEDEQRKRLQITKEEEKKERAYFKYNDDKEIWEFKSTQTLAPVSNSTSSTASDAASGSN
What are the official names of this protein?
Oxysterol-binding protein 7, OSBPg.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
Protein: RLMD_PSESM
Sequence: MAKHERGLRFQPTGGVKSVQIPAGKKQRLSIERLSDDGRGIAFLEGKTWFVAGSLAGEEVEARVLNARGKVVEARTERVFVASDLRRAPACDYFGRCGGCSVQHVPHEEQLALKQRMLAEQLLRVANVVPDEWAAPLSGAELAYRRRARVAVRWDAKAKRLDVGFRAAASQDIVSIEECPVLVQALQPIMSQLPAMLKSFSKPQVLGHVELFSGSSTAVLLRHTAPLAEADLATLQAFCKTHGAQLWLHGEGEPQPASPGDTLGYRLEPWNLQLAWRPGDFIQVNAAVNTAMIEQALHWLAPAADERVMDLFCGLGNFALPLASLAKDVVAVEGVATMVERAAVNAMSNDLHNVRFFQADLSQPLTHADWAAEGFSAVLLDPPRDGAFEVVRQIRKTGAQRLLYVSCNPATLARDTVELVKQGYRLKRAGILDMFPQTAHVEAMALFEVSK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: DBP4_COCIM
Sequence: MAPAHSRTGKPQKPFRQNNRSLKRKRNEDDLSSLTQRVGELDPKSLAESFSELPLSDATLQGLSASHFKTLTDIQSRAVPHAIKGRDILGAAKTGSGKTLAFLVPVLENLYRKQWTEYDGLGALILSPTRELAIQIFEVLRKIGRYHTFSAGLVIGGKSLQEEQERLGRMNILVCTPGRMLQHMDQTAAFDTAHIQMLVLDEADRIMDMGFQSTVDAIVEHLPKERQTMLFSATQTKKVSDLARLSLRDPEYISVHEAASSATPASLQQHYVVTPLPEKLDTLWSFIRNTLKSKILVFFSSSKQVRFVYEAFRHMQPGIPLLHLHGRQKQSARIDITSKFSRAKYSCLFSTDVAARGLDFPAVDWVIQLDCPEDADTYIHRVGRTARYERDGRAVLFLDPSEEEGMLKRLEQKKIPIERINIKAKKQQSIMNQLQNMCFKDPALKYLGQKAFTSYVKSVHIQKDKDVFNVKSLPLEEFASSLGLPGAPRIKFIKGEDTKSRKNAPRHLAVVPSSDEDSDEEGLTKKKKENEVRTKYDRMFERRNQDVLTEHYTKLIRDEDEIDPDEKDNPAADADEDDGFLSVKRRFDAGDENLGEGLGSEAEIDGIKKGKAVQIDGKEPLIIDSKRREKLLKSKKKLLKYKGKGTKLVYDDEGNAHEIYEMEDEQQFKAQGDADAQRAKYLELEAERTRLADIRDKEIAKQKKREKKEKRRARARAEREAEDGPVAVLAPYEEDEGLREDDFSAEDRGSEDGRAPPSKKQKKWFQSDSDVDGEDGGKKRKRPRAQSPAQVETLEDLEALAAELLE
What is the function of this protein?
ATP-dependent RNA helicase required for ribosome biogenesis.  Involved in the release of U14 snoRNA in pre-ribosomal complexes.  Required for pre-rRNA cleavage at site A2 (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HBEAG_HBVGO
Sequence: MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAILCWGELMTLASWVGNNLEDPASREQVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETAVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.  This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein, p25.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: RPOC_CHLPB
Sequence: MIFSQGVSPFKGDFSKIKFSIASPESILAHSRGEVLKPETINYRTFKPERDGLMCEKIFGPTKDWECYCGKYKRVRYKGIICDRCGVEVTMKSVRRERMGHISLAVPVVHTWFFRSVPSKIGALLDLSTKELERVIYYEVYVVINPGEPGEKQGIKKLDRLTEEQYFQIITEYEDNQDLDDNDPAKFVAKMGGEAIHTLLKGLELDTQAVDLRKILRESGSEQKRADALKRLKVVEAFRKSFEPVKKTRKKSTGLFPEDEAPEPYVYEGNKPEYMVMEVIPVIPPELRPLVPLEGGRFATSDLNDLYRRVIIRNNRLKKLIDIRAPEVILRNEKRMLQEAVDALFDNSRKANAVKTGESNRPLKSLSDALKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHECGLPKSMAIELFQPFVIRRLVERGIAKSVKSAKKLIDKKDPIVWDVLEKVIDGRPVLLNRAPTLHRLGIQAFQPVLIEGKAIQIHPLVCTAFNADFDGDQMAVHVPLSQEAQLEATLLMLSSHNLILPQSGKPVTVPSQDMVLGMYYLTKSRLGEKGQGKLFYGTEEVMIAFNEERIGLHALVFVHYDGRIEQKFDPLRMLDIIPDDQPEQKEWLKTKIGENKILVTTVGRVLFNRYVPEKIGFINKVIDKKGAKDLISKLSSEVGNVATAEFLDNIKQVGFHFAMKGGLSIGLADAIIPEVKVQHIKKATKESTKIVREYNRGTLTENERYNQIVDVWQKVTNLVAEESYQKLRKDRSGFNPLFMMLDSGARGSREQVRQLTGMRGLIARPQKSMSGQPGEIIENPIISNLKEGLTVLEYFVSTHGARKGLSDTSLKTADAGYLTRRLHDVAQDVIVTEDDCGTTRGIHVERGIEEETGGQIKFSEKIRGRVASRDIVDNLNDVVILPAGGIITDEIADAIQKNAGVVEADIRSVLTCEAKQGICSKCYGTNLSVHKLVEIGEAVGVIAAQSIGEPGTQLTLRTFHQGGTAQGGIAETETKSSMDGQVEFESIRSVEQETINEDGMPETVTLVIQKNGKINILDPDSGKFLKRYEVPHGAHLVCKNGDIVKKDDVLFSSEPNSTQIIAEVEGEVKFVDIDKGVTYKEEVDPQTGYVQHVIINWRTKLRASETREPRILIVDKEGETLKTYPVPIKSNLFIENGKKVKIGDMLAKVPRNLDRVGGDITAGLPKVTELFEARIPSDPAIVSEIDGYVGFGPQRRSSKEIKVKNEFGEEKNYYVQVGKHVLANEGDEVTAGEPLTDGAVSPQDILRIQGPNAVQQYLVNEIQKVYQINAGVEINDKHLEVIVRQMLQKVRVEEPGDTELLPGDLIDRTMFIRANSDVSEKVRVTSKGDAPARIHEGQLYKTREIIKLNRELRRNSKQLIDVEPALQATSHPVLLGITSAALQTESVISAASFQETTKVLTDAAVAGKIDNLAGLKENVIVGKLIPAGTGLKKYLKLSLDMLAEGKESADALAEEEAGAAESGEDDA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: PEO1_HUMAN
Sequence: MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEIRQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEGSWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMFGLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPRPSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQFRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTALPAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSGKTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNSEICSGQAPTPDQPDTSKRSK
What is the function of this protein?
Lack DNA unwinding and ATP hydrolysis activities (PubMed:18039713).  Does not bind single-stranded or double-stranded DNA (PubMed:18039713).
What are the official names of this protein?
Twinkle mtDNA helicase, Progressive external ophthalmoplegia 1 protein, T7 gp4-like protein with intramitochondrial nucleoid localization, T7-like mitochondrial DNA helicase, Twinkle protein, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion matrix, mitochondrion nucleoid. Note=Colocalizes with mtDNA in mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins associated with mtDNA, probably involved in mtDNA maintenance and expression.
Protein: G6PI_PSEU2
Sequence: MAYYRTPSDVTALPAWQALNKHRQAMQNFSMREAFNTDPQRFSQFTLSSAGLFLDYSKNLITTETRDLLVSLAGEVGLKDAIKAQYDGELVNSSEGRPALHTALRRPVGDKLKVNGVDVMPDVHRVLNQMTELVGRIHDGLWRGYTEKPITDVVNIGIGGSFLGPELVSEALVAYAHKGVRCHYLANIDGSEFHELSMKIRAETTLFIVSSKSFNTLETLKNAQAARAWYLAQGGSEVELHRHFIAVSSNNAAAVAFGIREENIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKELLSGAYTMDQHFQSAPFEQNMPVLLGLLGVWYGNFWNAQSHAILPYDHYLRNITKHLQQLDMESNGKSVRQDGTPTSTDTGPVIWGGVGANGQHAYHQLLHQGTQMIPADFIVPIVSFNPVADHHQWLYANCLSQSQALMMGKTRAEAEAELREKGMDEQEVQKLAPHKVIPGNRPSNTLVVERISPRRLGALVAMYEHKVFVQSVIWGTNAFDQWGVELGKEMGKAVYQRLTGGTEEQADDASTQGLINYFRGRHRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHB2_ARATH
Sequence: MSFNKVPNIPGAPALSALLKVSVIGGLGVYALTNSLYNVDGGHRAVMFNRLTGIKEKVYPEGTHFMVPWFERPIIYDVRARPYLVESTTGSHDLQMVKIGLRVLTRPMGDRLPQIYRTLGENYSERVLPSIIHETLKAVVAQYNASQLITQREAVSREIRKILTERASNFDIALDDVSITTLTFGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDRRSAVIRAQGEAKSAQLIGQAIANNQAFITLRKIEAAREIAQTIAQSANKVYLSSNDLLLNLQEMNLEPKK
What is the function of this protein?
Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
What are the official names of this protein?
Prohibitin-2, mitochondrial, Atphb2.
What is the protein family that this protein belongs to?
Belongs to the prohibitin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass type II membrane protein.
Protein: PHOP2_RAT
Sequence: MKVLLVFDFDNTIIDDNSDTWIIQCAPDKKLPIELQDSYQKGLWTEFMGRVFKYLRDEGVKEEELKRAVTSLPFTSGMIELLSFLRMNKDRFDCIIISDSNSIFIDWVLEAAAFHDVFDTVFTNPASFDSTGRLTVRNCHTHACTRCPKNLCKNTVLGEFIDKQLQKGVRYTRIVYIGDGGNDVCPVTFLKKNDVAMPREGYTLHRTLDKMSQNLEPMASSIVVWSSGMEIISHLQFLIQM
What is the function of this protein?
Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP).  Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.
What are the official names of this protein?
Pyridoxal phosphate phosphatase PHOSPHO2.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
Protein: LSRB_ECO57
Sequence: MTLHRFKKIALLSALGIAAISMNVQAAERIAFIPKLVGVGFFTSGGNGAQQAGKELGVDVTYDGPTEPSVSGQVQLINNFVNQGYNAIIVSAVSPDGLCPALKRAMQRGVRVLTWDSDTKPECRSYYINQGTPAQLGGMLVDMAARQVNKDKAKVAFFYSSPTVTDQNQWVKEAKAKIAKEHPGWEIVTTQFGYNDATKSLQTAEGILKAYSDLDAIIAPDANALPAAAQAAENLKNDKVAIVGFSTPNVMRPYVERGTVKEFGLWDVVQQGKISVYVADALLKKGSMKTGDKLDIQGVGQVEVSPNSVQGYDYEADGNGIVLLPERVIFNKENIGKYDF
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
What are the official names of this protein?
Autoinducer 2-binding protein LsrB, AI-2-binding protein LsrB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 2 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HLDD_NEIG1
Sequence: MTIIVTGAAGFIGSNIVKALNQRGITDIVAVDNLTKGEKFKNLAECEIAHYLDKHEFIRQVREHILPYQNIEAVFHQGACSDTMNHDGLYMMENNYQYTLDLLDWCQDERIPFLYASSAAVYGKGEIFREERELEKPLNVYGYSKFLFDQVLRRRMKEGLTAQVVGFRYFNVYGQHEQHKGRMASVAFHHFHQYREHGYVNLFGSNDGYGNGEQTRDFVSVEDVAKINLYFFDHPELSGIYNLGTGRSQQFNELAAAAVNACRAAEGKSELSLKELVEEELIRYIPFPDALKGKYQGFTQADITKLREAGYKEEFFDVKAGVNRYVKWMLENLA
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: DUS6_MOUSE
Sequence: MIDTLRPVPFASEMAICKTVSWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPTPQLYFTTPSNQNVYQVDSLQST
What is the function of this protein?
Inactivates MAP kinases.  Has a specificity for the ERK family (By similarity).  Plays an important role in alleviating acute postoperative pain (PubMed:24155322, PubMed:28405172).  Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (PubMed:24155322).  Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (PubMed:28405172).
What are the official names of this protein?
Dual specificity protein phosphatase 6, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_STRP8
Sequence: MQLLEERILTDGNILGENILKVDNFLTHQVDYRLMKAIGKVFAQKYAEAGITKVVTIEASGIAPAVYAAEAMDVPMIFAKKHKNITMTEGILTAEVYSFTKQVTSTVSIAGKFLSKEDKVLIIDDFLANGQAAKGLIEIIGQAGAQVVGVGIVIEKSFQDGRRLIEDMGIEVTSLARIKNFENGNLNFLEADA
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETB_PSEA7
Sequence: MARFEEQKLYIGGRYVEASSGATFETINPANGEVLAKVQRASREDVERAVQSAVEGQKVWAAMTAMQRSRILRRAVDLLRERNDELAALETLDTGKPLAETRAVDIVTGADVLEYYAGLVPAIEGEQIPLRETSFVYTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYTEAGVPDGVFNVLTGSGREVGQWLTEHPLIEKISFTGGTSTGKKVMASASSSSLKEVTMELGGKSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQARFEAKVLERVQRIRLGDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVTEGAFGNGAYVAPTVFTDCSDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAGVVTQDLARAHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGLTTLAHYTRIKSVQVELGDYASVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.