PharMolix/UniProtQA huggingface dataset:
Protein: ZTP50_ARATH
Sequence: MFVRSNILRALIFTVLEKTCLEIKMMHSSCKGLVLLLFLFVVVFIGNTDANAQWEVSHKVRASPHENMGRNVIDGSGVEKTLHDIGMGEKRGTHNKVSVSTVALFTLAMAAATGLGAVPFFFVELDPQWAGICNGMAAGVMLAASFDLVKEGQEHGSGNWVVTGILAGALFIWLCKQILEQYGEVSMLDIKGADATKVVLVIGIMTLHSFGEGSGVGVSFAGSKGFSQGLLVTLAIAVHNIPEGLAVSMVLASRGVSPQNAMLWSIITSLPQPLVAVPAFLCADAFSKFLPFCTGFAAGCMIWMVIAEVLPDAFKEASPSQVASAATISVASMEALSTLFESFTHDYNSEDASGFFVSLLFGLGPLLGGVFLVASAVTFRLQHALLMGVASGIAFVLGLWRPLQLLLSAKMGLIPLVSLLAIGAGLSHFTSSTILNVTGRKKSRAGSLINPVTNFPTSVITLQSLLACGAVGFHALAEGLALGVAAPNAYGLGRHMVLPVSLHGLPRGTAVASCVFGATDSWHAALAAAALIGFVGPISAIGSILAGIDYSGLDHVMVVACGGLLPSFWQVIKRAVRLERRKGSVGMVLGLACAVVCLTFTRLVCLHTPYCNSAPEAVR
What is the function of this protein?
May transport zinc.
What are the official names of this protein?
Putative zinc transporter At3g08650.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ST_POVBO
Sequence: MELTSEEYEELRGLLGTPDIGNADTLKKAFLKACKVHHPDKGGNEEAMKRLLYLYNKAKIAASATTSQVWYFLIIGYISLKNKNIYLPKIFWLRFQNMAPHSGNSGGKNSIKALMSKICIVMRN
What is the function of this protein?
Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle.
What are the official names of this protein?
Small t antigen, ST, ST-AG.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: RNZ_LATSS
Sequence: MELEFLGTGAGVPARQRNVTSIALKLLDERNEVWLFDVGEATQHQILKTTLKPRKVKKIFLTHLHGDHLFGLPGFLSSRSFQGGDEPLTIYGPKGTEEYVRTSLKLSESHLTYALKFVVLPENGVIIDDKTFRVECAKLDHRIASYGFRIVEKDHPGELQVEKLQADGVPSGPVYARIKNGETVTLSDGREIDGRNYIGNAQKGRIVTIIGDTRNCEAITRLAENADVLVHESTFGKQEQKIARQYYHSTNINAAKVAKTAHVKRLLLTHISARYLGQAVRELQNDARDIFKNTRVVSDLDLYDIPFHGRKE
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: HSLV_CHESB
Sequence: MSDNLTMHGTTIVTVRKGGKVVIAGDGQVSLGQTVMKGNARKVRRIGKGNVIAGFAGATADAFTLLERLEKKLEQYPDQLMRASVELAKDWRTDRYLRRLEAMMLVADKNVTLALTGTGDVLEPEEGVMAIGSGGNYALAAARALIDTDKSAEEIARKAMEIAASICVYTNSNIIVETLDAG
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FJX1_MOUSE
Sequence: MGRKMRGAAAAAGLWLLALSSLLTLWGGLLPPRTELPASRPPEDRLPPHPIQSGGPAPEPRFPLPPPLVWDARGGSLKTFRALLTLAAGADNPPRRHQDDRGRHEPSGLSWPEERRAVHGGVFWSRGLEEQVPRGFSEAQAAAWLEVARGARVVALDRGGCGRSSNRLARFADGTRACVRYGINPEQIQGEALSYYLARLLGLQRHVPPLALARVEARGAQWVQVQEELRTAHWTEGSVVSLTRWLPNLTDVVVPEPWRSEDGRLRPLRDAGGELTNLSQAELVDLVQWTDLILFDYLTANFDRLVSNLFSLQWDPRVMHRATSNLHRGPGGALVFLDNEAGLVHGYRVAGMWDKYNEPLLQSVCVFRERTARRVLELHRGQDAAARLLRLYSRHEPRFPELAELSEPHAQLLQRRLDFLAKHILHCKAKYGRRPGDLITLRGREGLGYE
What is the function of this protein?
Acts as an inhibitor of dendrite extension and branching.
What are the official names of this protein?
Four-jointed box protein 1, Four-jointed protein x1, Four-jointed protein homolog.
What is the protein family that this protein belongs to?
Belongs to the FJX1/FJ family.
What are the subcellular locations of this protein?
Secreted.
Protein: FTSP_SALTI
Sequence: MSFSRRQFLQASGIALCAGAIPLRANAAGQQQPLPVPPLLESRRGQPLFMTLQRAHWSFTQGTRAPVWGVNGRYLGPTIRVWKGDDVKLIYSNRLAENVSMTVAGLLVPGPLMGGPARMMSPNADWAPVLPIRQSAATLWYHANTPNRTAQQVYNGLAGMWLVEDDISKTLPIPNHYGVDDFPVIIQDKRLDNFGTPEYSEPGSGGFVGDTLLVNGAQSPYVEVSRGWVRLRLLNASNSRRYQLQMSDGRALHVISGDQGFLPAPVSVKQLSLAPGERREILVDMTNGDEVSITCGEAASIVDRIRGFFEPSSILVSTLVLTLRPTGLLPLVTDNLPMRLLPTEIMSGAPVRSRDISLGDDPGINGQLWDVNRIDITAQQGTWERWTVRADMPQSFHIEGVSFLIRNVNGAMPFPEDRGWKDTVWVDGQVELLVYYGQPSWPHFPFYFNSQTLEMADRGSIGQMLVNPAS
What is the function of this protein?
Cell division protein that is required for growth during stress conditions.  May be involved in protecting or stabilizing the divisomal assembly under conditions of stress.
What are the official names of this protein?
Cell division protein FtsP.
What is the protein family that this protein belongs to?
Belongs to the FtsP family.
What are the subcellular locations of this protein?
Periplasm. Note=Localizes to the division septum.
Protein: DGOD_ECO7I
Sequence: MKITKITTYRLPPRWMFLKIETDEGVVGWGEPVIEGRARTVEAAVHELSDYLIGQDPSRINDLWQVMYRAGFYRGGPILMSAIAGIDQALWDIKGKVLNAPVWQLMGGLVRDKIKAYSWVGGDRPADVIDGIKTLREIGFDTFKLNGCEELGLIDNSRAVDAAVNTVAQIREAFGNQIEFGLDFHGRVSAPMAKVLIKELEPYRPLFIEEPVLAEQAEYYPKLAAQTHIPLAAGERMFSRFDFKRVLEAGGISILQPDLSHAGGITECYKIAGMAEAYDVTLAPHCPLGPIALAACLHIDFVSYNAVLQEQSMGIHYNKGAELLDFVKNKEDFSMVGGFFKPLTKPGLGVEIDEAKVIEFSKNAPDWRNPLWRHEDNSVAEW
What is the function of this protein?
Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
What are the official names of this protein?
D-galactonate dehydratase, GalD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: IOVO_LOPDI
Sequence: LAAVSVDCSEYPKPACTMEYRPLCGSDNKSYDNKCNFCNAVVESNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: NRDJ_LEPIC
Sequence: MKMNRHFTVPQNGESSTIQWTKRNSKITNPDGSKVFEANDILVPEDWSQVAVDILAQKYFRRKGVPKYLKKVQEDGIPEWLQKSIPDTEKLESLKPEDRFGGETSALEVFHRLAGCWTYWGYKYKYFSDEESAKIFYDEIVYMLATQMAAPNSPQWFNTGLNWAYGIDGKSQGHYYVDPSTGKLVKSTSAYEHPQPHACFIQSVDDDLVNEGGIMDLWVREARLFKYGSGTGTNFSNLRGENEPLSGGGKSSGLMSFLKIGDRAAGAIKSGGTTRRAAKMVCLDVDHPDIENFIDWKVTEEKKVASLVTGSMLNNRHLNAIMSACYEMEGEDRFNPKKNSSLKKTIQDAKKVLIPDNYIKRVIDLARQGYKEILFEELTTDWQSDAYNTVSGQNSNNSIRLTNEFMAAVEQDQPWNLYFRTEKEKAKVEGRKAKPSQTLRARELWEKISYAAWASADPGTQYHTTINEWHTCPEDGPINASNPCSEYMFLDNTACNLASANLQKFVNLETLNFDVEGFRYLCKLWTIILEISVTMAQFPSKEIAELSYKFRTLGLGYANLGSVLMVLGIPYDSQQAMAITGAISSIMHMTAYATSAEMAKEQGPFVGYAKNQKHMLRVIRNHRRAAYNAPSGDYEGLTITPIGINPAFCPSYMLKAAQEDADLALSLGEKYGFRNAQVTVIAPTGTIGLVMDCDTTGIEPDFALVKFKKLAGGGYFKIINQSVPYGLKKLGYSPSEIEAIVNYCKGHATLNGAPVINTQALKEKGFTNEILEKVEASLPLAFDINFAFNKFNLGENFLTKNLGISKEIFDSPGFSLLEHLGFTKEDINKANDYVCGTMTIENAPFLKEKDYPVFDCANKCGKYGKRFLSYESHIRIMAAAQPFISGAISKTINLPEEAVIEDIKNAYFLSWKMMIKANALYRDGSKLSQPLNSVLELLNGIEIDDQEEIREATISKDPVQIAEKIVTKYISHRRKLPSRRAGYTQKAIVGGHKVYLRTGEYEDGQIGEIFIDMHKEGAAFRSLMNAFAISVSLGLQHGVPLEEYVDAFTFFKFEPNGIVSGNKHIKMSTSVIDYIFRELAITYLGRYDLGQVAPEDLRGDEIGSKRATAESNGQEKETLSSMTAVIEPTPKKEVETISYSQMISKEKPSSSPSGISLLEEVKLAKIKGYTGDSCSECGSFEMVRNGSCLKCMSCGSTTGCS
What is the function of this protein?
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides.  May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen (By similarity).
What are the official names of this protein?
Vitamin B12-dependent ribonucleotide reductase, Ribonucleoside-diphosphate reductase NrdJ.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase class-2 family.
Protein: MBOA4_DANRE
Sequence: MIDLLWISSDGHPQLFYQFINIPFAFLFHCLSSQGHLSIINRYVYLAMGGFMLAIATMGPYSSLLFLSAIKLLLLIHYIHPMHLHRWILGLQMCWQTCWHLYVQYQIYWLQEAPDSRLLLAISALMLMTQRISSLSLDFQEGTISNQSILIPFLTYSLYFPALLGGPLCSFNAFVQSVERQHTSMTSYLGNLTSKISQVIVLVWIKQLFSELLKSATFNIDSVCLDVLWIWIFSLTLRLNYYAHWKMSECVNNAAGLGVYFHKHSGQTSWDELSDGSVLVTEASSRPSVFARKWNQTTVDWLRKIVFNRTSRSPLFMTFGFSALWHGLHPGQILGFLIWAVTVQADYKLHRFSHPKLNSLWRKRLYVCVNWAFTQLTVACVVVCVELQSLASVKLLWSSCIAVFPLLSALILIIL
What is the function of this protein?
Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (By similarity) (PubMed:18443287).  In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (By similarity).
What are the official names of this protein?
Ghrelin O-acyltransferase, Membrane-bound O-acyltransferase domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CPRT_SBWMN
Sequence: MAVNKGYTGYNKELNAMAATHAYIRLSTLMSQIESWQATRASVLTHLGVMLNGVSKLGERSFFSRTKRFGAHTSDGDEIFCDLGGEAVTQILSRLTVALQSARGEGAQTRNAKRGAAPGTSQVENEEQGQTDQTLAISNAVAELMIFVRTKDFTMNECYTQDSFEAKYNLKWEGSSXRDGVSGKLRAQIVEEFQNRLIIADDLGIFPRRDVDGVIIRNEPEVVYSELEDKLLSFESSVYHPKAVTVEFEVPVATGTTTTDDEITTEDVEMVIVTEVLVDDESDYYWLYFVLLLTSFLITCFILLSRRFIHFLGNRGGPGAPLCRRFATRLWSIRLWLLRKATRRYGNLGVVRKTHSQTTMRKYLRDYNFQLEEWETAIGCTPREALIVADQHILVRAVQRIVDSVGDVDSVDAVRKVFNGYKVRNFKIEKWLNKQTVNSALAVLNDSTVPENVVLSEGMLSLQTATFEEVLRCNVESQRESAYFNELIALQFAFRLVGTPEFSDFVLAYKGPAYPCYVEAINRHGTCIIQHHVDEDQKRKNDRAIEWLLMAGQGAFVVSSVVTTGVVVFKIHKWLKQRLLLRALSMLPSVGGGGNGGGGGSLPPQALELFDRAGTFEERLAALQNGLDLSPENMEVFTPEELKTEIRHVVQAYADSSYHVADEPYLRGVGVTVVTGLPEAVGEITTTGSEVSSVDTSISLGVPGRARRRAVSKNTRMYPSTSGQSYNSYKSPRVSGKSGVGSMKMKIASKPMAS
What is the function of this protein?
Minor capsid protein involved in virus transmission by the vector.
What are the official names of this protein?
84 kDa readthrough protein, CP-RT.
What is the protein family that this protein belongs to?
Belongs to the virgaviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Note=Associated with one extremity of viral particles.
Protein: AROC_BIFAA
Sequence: MLRWQTAGESHGEALVAMIEGLPAGIHVTTEDIVGALARRRLGYGRGARMKFEQDKVRMLTGVRFGETIGSPVAIEIANTEWPKWTEVMSADPLDHDIPREGRNAPLSRPRPGHADLTGMRKYGFDDARPVLERSSARETASRVALGEVAKQFLEQTLGIRTVSHVLSIGGAGITDPQNAVLPKPEDLEALDASPVRTLDKTAEQQMIARIDEAKENADTLGGVIEVVVYGVPAGIGTYVESDRRLDAALASAVMGVQAIKGVEIGDGFLEAMRPGSQAHDEMAVGDDGRITRLSNRAGGIEGGMSNGQPIVVRAAMKPIPSIPKALRTVDVTTGEAAQAINQRSDNTAVPAAAVVAEAMVRLTIAQYVLEKFGGDSVAETKRNAESYVASWPEHMR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: 1A_CMVNT
Sequence: MATSSFNINELVASHGDKGLLATALVDKTAHEQLEEQLQHQRRGRKVYIRNVLGVKDSEVIRNRYGGKYDLHLTQQEFAPHGLAGALRLCETLDCLDSFPSSGLRQDLVLDFGGSWVTHYLRGHNVHCCSPCLGIRDKMRHAERLMNMRKIILNDPQQFDGRQPDFCTHPAADCKVQAHFAISIHGGYDMGFRGLCEAMNAHGTTILKGTMMFDGAMMFDDQGVIPELNCQWRKIRTAFSETEDATPLSEKLNSTIFSHVRKFKTMVAFDFINESTMSYVHDWENIKSFLTDQTYSYRGMTYGIERCVIHAGIMTYKIIGVPGMCPPELIRHCIWFPSIKDYVGLKIPASQDLVEWKTVRILTSTLRETEEIAMRCYNDKKAWMEQFKVILGVLSAKSSTIVINGMSMQSGERIDINDYHYIGFAILLHTKMKYEQLGKMYDMWNASYISKWFAALTRPLRVFFSSVVHALFPTLRPREEKEFLIKLSTFVTFNVECSFDGGEEWDVISSAAYVATQAVTDGKVLAAQKAEKLAEKLAQPVIEVSDRPEAPSSTPDDTADVCGKEQEVSELDSLSAQTRSPITRVAERATAMLEYAAYEKQLHDTTVSNLKRIWNMAGGDDKRNSLEGNLKFVFDTYFTVDPMVNIHFSTGRWMRPVPEGIVYSVGFNERGLGPKSDGELYIVNSECVICNSESLSTVTRSLQAPTGTISQVDGVAGCGKTTAIKSIFEPSTDMIVTANKKSAQDVRMALFKSSDSKEACTFVRTADSVLLNECPTVSRVLVDEVVLLHFGQLCAVMSKLKAVRAICFGDSEQIAFSSRDASFDMRFSKIIPDETSDADTTFRSPQDVVPLVRLMATKALPKGTHSKYTKWVSQSKVKRSVTSRAIASVTLVDLDSSRFYITMTQADKASLISRAKEMNLPKTFWNERIKTVHESQGISEDHVTLVRLKSTKCDLFKQFSYCLVALTRHKVTFRYEHCGVLNGDLIAECIARA
What is the function of this protein?
Involved in the virus replication.  Contains a helicase domain and a methyltransferase domain.  The methyltransferase domain is probably involved in viral RNA capping.  Involved in the formation of ER membrane spherular invaginations in which RNA replication complexes form (By similarity).
What are the official names of this protein?
Replication protein 1a.
What is the protein family that this protein belongs to?
Belongs to the bromoviridae replication protein 1a family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: THIG_VIBVU
Sequence: MLKIADKQFHSRLFTGTGKFANSQLMSQAIEQSGSQLATMALKRVDIHNQQDDILSPLLSAGVNLLPNTSGAKNAKDAIFAAHLAREALGTNWLKLEIHPDPKYLMPDPIETLAAAEQLVKDGFVVLPYCHADPVLCKRLEEVGCAAVMPLGAPIGSNKGLVSQDFLQIIIDQAKVPVVVDAGIGAPSHAAYAMELGADAVLVNTAIAAARDPIAMARAFKLAVEAGRLAYESGLAGKVSHAVASSPLTSFLDECLS
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBL9_ARATH
Sequence: MGVLLPIFFGVLLLFTVTPPSMSQLPPTIMVPAPAPAPISPSDLCNGIFLSYDFILGRKIPPNDTADQPYRFESVLTVLNNGREELKEWRVFVGFQHNEILISATDALIVNGTELPALVGNGTIFGGYPVSDLKTAIQTAGDLKQMTAEIELVGTQFMVAPPAVPLPSNISLVNEGWLCPVPTLQSKRELTTCCIRDASIIVNTTITTKFLPRQPGDLTIMYDVIRAYDQNYLTEVTMENHNPLGRLDHWELSFDWMRDEFIQKMQGAYPTVVDATKCIFGPQSLIYTGLDFADVLTCERRPIIIDLPPTKKDDSTLGNIPSCCRNGTILPRIMDPSKSVSVFTMQVAKMPPDFNRSALFPPQNWRIKGTLNPDYSCGPPVRVTPTFYPDPSGMPTNKSSFASWQIVCNITQAKTEIPKCCVSFSAFFNDSIIPCNTCACGCVSETRRTCSAETPSLLIPPDALLLPFENRTALTLAWNALKHKTLPNPMPCGDNCGVSINWHMASDYRGGWTVRITIFNWGEIDFPNWFLAVQMKKPALLGFEKAYSFNASLLSVDGGVNNTIFMEGLPGLDYLVAEADEKDPKKKNIRIPGKQQSVIQFSKKLTPGINVAERDGFPAKVIFNGEECLLPDLLPMASGGRRNGAITVLSFITFYVAAFMVLL
What are the official names of this protein?
COBRA-like protein 9.
What is the protein family that this protein belongs to?
Belongs to the COBRA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: S22AB_HUMAN
Sequence: MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTSL
What is the function of this protein?
Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds (PubMed:10660625, PubMed:11907186, PubMed:15291761, PubMed:15037815, PubMed:15102942, PubMed:15576633, PubMed:17229912, PubMed:18501590, PubMed:26277985, PubMed:28027879).  May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus (PubMed:12409283).  Maybe also be involved in placental urate homeostasis (PubMed:17229912).  Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates (PubMed:15037815, PubMed:17229912).  Organic anion glutarate acts as conteranion for E1S renal uptake (PubMed:15037815, PubMed:17229912).  Possible transport mode may also include DHEA-S/E1S exchange (PubMed:28027879).  Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-) (PubMed:17229912).  Also mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186).  Also able to uptake anionic drugs, diuretics, bile salts and ochratoxin A (PubMed:10660625, PubMed:26277985).  Mediates the unidirectional efflux of glutamate and aspartate (PubMed:28027879).  Glutamate efflux down its transmembrane gradient may drive SLC22A11/OAT4-mediated placental uptake of E1S (PubMed:26277985).
What are the official names of this protein?
Solute carrier family 22 member 11, Organic anion transporter 4, OAT4, Organic anion:dicarboxylate exchanger OAT4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Protein: T23O_XENTR
Sequence: MSGCPFMGKKHHFNFSELSLEDKNEDSSQEGLNKASKGGLIYGDYLQLDKVLNAQELQSEKKGNKIHDEHLFIVTHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVTRIHRISMILKLLVEQFSVLETMTAMDFFDFRDYLSPASGFQSLQFRLLENKIGVPEILRVPYNRRHYRDNFKGETNELLLKSEQELTLLGLVEAWLERTPGLEEEGFHFWGKLEANIFRGLEEELQTVKTKPDSEEKEEQLAELQKQKELFGALFDERRHEHLLSKGERRLSYKALKGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMIGSKAGTGGSSGYQYLRSTVSDRYKVFVDLFNLSTYLVPRHWVPRLNPSIHKFLYTAECCDSSYFSSDDSD
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: NCTR2_HUMAN
Sequence: MAWRALHPLLLLLLLFPGSQAQSKAQVLQSVAGQTLTVRCQYPPTGSLYEKKGWCKEASALVCIRLVTSSKPRTMAWTSRFTIWDDPDAGFFTVTMTDLREEDSGHYWCRIYRPSDNSVSKSVRFYLVVSPASASTQTSWTPRDLVSSQTQTQSCVPPTAGARQAPESPSTIPVPSQPQNSTLRPGPAAPIALVPVFCGLLVAKSLVLSALLVWWGDIWWKTMMELRSLDTQKATCHLQQVTDLPWTSVSSPVEREILYHTVARTKISDDDDEHTL
What is the function of this protein?
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
What are the official names of this protein?
Natural cytotoxicity triggering receptor 2, Lymphocyte antigen 95 homolog, NK cell-activating receptor, Natural killer cell p44-related protein, NK-p44, NKp44.
What is the protein family that this protein belongs to?
Belongs to the natural cytotoxicity receptor (NCR) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NUOD_ROSDO
Sequence: MMDGTKGFEDALTGEQKIRNFNINFGPQHPAAHGVLRLVLELDGEIVERCDPHIGLLHRGTEKLMESRTYLQNLPYFDRLDYVAPMNQEHAWCLAIEKLTGVEVPRRASLIRVLFCEIGRILNHILNITTQAMDVGALTPPLWGFEEREKLMVFYERASGARLHAAYFRPGGVHQDLPPALIDDIETWAHEFPRVIDDIDGLLTENRIFKQRNADIGVVTEEDILEYGFSGVMVRGSGLAWDLRRAQPYERYDEFDFQIPIGKNGDCYDRYLVRMEEMRQSLSIILQAIAKLRAPEGQGDVLARGKITPPSRSDMKTSMESLIHHFKLYTEGFHVPAGEVYACVEAPKGEFGVYLVADGTNKPYRAKIRAPGFLHLQAMDHMSRGHQLADVAAIIGTMDVVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NUOD_HYDCU
Sequence: MSEIRNYTLNFGPQHPSAHGVLRLVLELDGETIVRSDPHIGLLHRGTEKLAEYKPFNQSIGYMDRLDYVSMMANEHAYVMGIEKMLGIEVPERAQYIRVMFDEITRILNHLMWLGAHALDIGAMTVFLYAFREREDLMDCYEAVSGARMHATYYRPGGVYRDLPDTMAKYEESKWHSGKKLDQLNETREGSLLDFIEAFTERFPGYVDEYETLLTDNRIWKQRTVDIGIVSPERALQLGFTGPMLRGSGIAWDLRKKQPYEVYDKLDFDIPVGATGDCYDRYLVRVAEMRESNKIIKQCVKWLKENPGPVISDDHKVTPPSREDAKSNMEALIHHFKLFTEGYSVPEGESYTAVEHPKGEFGIYMVSDGANKPYRLKVRAPGFAHLASLDEMAKGHMIADVVAIIGTQDIVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MCM5_ARATH
Sequence: MSGWDEGAVYYSDQPQFPEAGDAATISPHAVLTKFKEFIRNFEIEQNCFPYREALLDNPKRLVVHLEDLLSFDSDLPSLIRSAPADYLPVFEKAAGEVLTGLKMREANEGGVMEEPLTRDVQILLTSREDPVSMRLLGAQYISKLVKISGISIAASRVKAKATYVFLVCKNCKKTREVPCRPGLGGAIVPRSCDNIPQPGEEPCPLDPWMVVPDRSQYVDQQTLKLQENPEDVPTGELPRNMLLSVDRHLVQTIVPGTRLTVMGIYSIFQASSSSNSHKGAVAIRQPYIRVVGLEDTNEASSRGPANFTPDEEEEFKKFADSQDVYKNICTKIAPSIFGHEDVKRAAACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDIRKYSQDKEIASHIIRVHASANKFSDENTDSKEDNWLKRYIQYCRARCHPRLSKDAAENLQRKYVTIRMDMKRRAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHEATPDDVDKAFKLFDTSTMDAARSGINQQINITGEMANEIKQAETQIKRRMGIGARLSERRLIEDLARMGMNDSMVRRALLIMHQRGEVEYQRERRSIVRKA
What is the function of this protein?
Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.
What are the official names of this protein?
DNA replication licensing factor MCM5, Minichromosome maintenance protein 5, AtMCM5.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localized in the nucleus during G1, S and G2 phases of the cell cycle, and released into the cytoplasmic compartment during mitosis.
Protein: CLPX_SALPA
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRTHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVIANRVETGSGIGFGATVKAKSDKASEGELLSQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIARKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIAGQSKPLLIYGKPEAQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.