PharMolix/UniProtQA huggingface dataset:
Protein: LEUD_CLOBB
Sequence: MNVKGRVFKYGDNVDTDVIIPARYLNTSNHKELASHCMEDIDKEFVNNVKDGDIIVANKNFGCGSSREHAPIAIKAAGISCVIASTFARIFYRNSINIGLPILECDEAVKNINHGDELEVDFSTGIIKNLSKNEQYQGEAFPEFMQKIIDNDGLIGYIRNK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: NU5M_RHIUN
Sequence: MNIFPSLMLTSLFTLTLPIIASTLNIHKNSNTPHHMKNIISFAFIISLIPTMMFIYSGQEMIISNWHWMTTQTLKLSLSFKLDYFSMIFVPVALFVTWSIMEFSIWYMHSDPHITQFFKYLLMFLITMMILVTANNLFQLFIGWEGVGIMSFLLIGWWYGRTDANTAALQAILYNRIGDIGFIMSMAWFLSNMNSWDLQQIFTLDPNHTNLPLMGLLLAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFHPLMENNKTAQTLTLCLGAITTLFTAICALTQNDIKKIIAFSTSSQLGLMIVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLFKTMPFTATSLIIGSFALTGMPFLTGFYSKDLIIETANTSYTNAWALLMTLIATSLTAAYSTRMIFFTLLGQPRFPTLITINENNPHLTNSIKRLLIGSIFAGFFISNNIYPTTTPKMTMPSYLKLMALIVTILGFALALELSLATYNLKFKHPSNPLKFSSLLGYFPTIFHRLPPSMGLLASQKSASLLLDSMWLENILPKSISLFQMKSSTLVSNQKGLIKLYFLSFLITLTLSLLLLTPHG
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TPS30_ARATH
Sequence: MAVARTVFGLGTLSYLHQAPLFLKTSQSLFPRPSLSLKPMKHDFVCVKATTKSSTSDDLESGRPSILFSPSIWGDYFLSVSVDDSEFDDIAREIESVMKPYVRDRLISSHNSNKDKIRLIHLLISLGISYYFESEIEMILNKAFEELDMIIAEEDDLETISIMFEVFRLYQHKMSCDSFVRFKGEDGRLKESLVGDVRGMLQLYQAAHLGTPSDQYIMEEAKSFTRNHLESLVESTTIPPHFSSHIRDALYIDRYHNMEILVARKYISFYEQEEGHDLTLLKFGKLSFNYCRLHYIQELKTLTKWWKDQDIPSNLPCVRDRIVETYFPTLGLYFEPRFSLGRIIIAKMTIIVVALNDVCDSYATYPEAKSLIDSLQRWDIEAIDELPNYSRIVLRLILETIGEIEREMKPRGRSASVQHTIDETKSLGRAYLALSKWASEGYMPTFDEYMEVGEVTGGMDDFALYSFIAMEDCDEKPLYEWFDSKPKILQALSVLYRINNDIVTYEREMSKGEVVNGVNSYMNQHGVTKEEAVEELRKMARDNYKIVMEELLTITDVPRPVLVRCLNLARLFDVFCKHGNDEFTYPHGNLKDLITSIFIHPIPV
What is the function of this protein?
Involved in terpene biosynthesis in roots.  Possesses sesquiterpene (C15) synthase activity and diterpene (C20) synthase activity in vitro.
What are the official names of this protein?
Terpenoid synthase 30, AtTPS30.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7A2_ARATH
Sequence: MAPKKGVKVASKKKPEKVTNPLFERRPKQFGIGGALPPKKDLSRYIKWPKSIRLQRQKRILKQRLKVPPALNQFTKTLDKNLATSLFKILLKYRPEDKAAKKERLLNKAQAEAEGKPAESKKPIVVKYGLNHVTYLIEQNKAQLVVIAHDVDPIELVVWLPALCRKMEVPYCIVKGKSRLGAVVHQKTAAALCLTTVKNEDKLEFSKILEAIKANFNDKYEEYRKKWGGGIMGSKSQAKTKAKERVIAKEAAQRMN
What are the official names of this protein?
60S ribosomal protein L7a-2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
Protein: TRAF4_HUMAN
Sequence: MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
What is the function of this protein?
Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522).  Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854).  Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633).  Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935).  In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522).  Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors.  Required for normal skeleton development, and for normal development of the respiratory tract (By similarity).  Required for activation of RPS6KB1 in response to TNF signaling.  Modulates TRAF6 functions.  Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273).
What are the official names of this protein?
TNF receptor-associated factor 4, Cysteine-rich domain associated with RING and Traf domains protein 1, Metastatic lymph node gene 62 protein, MLN 62, RING finger protein 83.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family. B subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Protein: RUVA_THET8
Sequence: MIRYLRGLVLKKEAGGFVLLAGGVGFFLQAPTPFLQALEEGKEVGVHTHLLLKEEGLSLYGFPDEENLALFELLLSVSGVGPKVALALLSALPPRLLARALLEGDARLLTSASGVGRRLAERIALELKGKVPPHLLAGEKVESEAAEEAVMALAALGFKEAQARAVVLDLLAQNPKARAQDLIKEALKRLR
What is the function of this protein?
Binds Holliday junction (HJ) but not linear dsDNA.  The RuvA-RuvB complex promotes HJ branch migration in an ATP-dependent manner; ATP-gamma-S does not allow migration.  Stimulates the ATPase activity of RuvB in the presence of dsDNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: ENY2_CIOIN
Sequence: MADYGSDKKSRDNQMRSAINQQLVETGEREKLKELLRVRLAECGWRDQLKQLCKEIVRERGLEHVSVDDLVQDITPKARQLVPDTVKKELLQKIRNFLAQQANV
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes.  The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histones.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).
What are the official names of this protein?
Transcription and mRNA export factor ENY2, Enhancer of yellow 2 transcription factor homolog.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: LECM1_HYDHA
Sequence: MGRFLFASLGLLVVAFSLSGTGANLYCPFDWLSYNVSCYKLFYSLVTWDQAQRFCVEQQENSQLASIHDVGESVKLSNYISQRWGFFDVWMGLRLSKRNGIWEWSDGSNLTYTSWKEGEPNNLFNMEFCAVLSAGTRYLQWNDKKCTLLHPFLCQFQPRSEANG
What is the function of this protein?
Mannose-binding lectin which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids.  May be a calcium-dependent lectin (By similarity).
What are the official names of this protein?
C-type lectin 1, CTL.
What is the protein family that this protein belongs to?
Belongs to the true venom lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FOLD_CLOB8
Sequence: MGQIINGKEVALKVKEEIKNFVNNRKEKNLQVPKIASILVGNDGGSIYYMGSQEKVANSLGVEFLKLTLPETCNDEDVIAEINKLNEDNNIHGIILQLPLPNNFDEKKIIKQISPNKDIDCLTFESQGKLYMGEPKFLPCTPNSVITLIKSLNIDIVGKNVVVLGRSNIVGKPVAQLLLNENATVTICHSKTKNLREVCKNADILVVAIGRPKFIDETYVNENAIVIDVGTSSFEGKITGDVDFDKVIDKCRYLTPVPGGVGSLTTTLLIKNACEALQENEY
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: LCKB2_ARATH
Sequence: MLRSTCCTPLCPFTAKQPSFLRKQQRITSDRFTFRGGGGGDAAAVVSSSGLRDLVFVVNPQGANGRTAKEWKKLLPHLRSRLGKDCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNGFFWEGKPVGYLSGEASRSTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDKEGKDLHYFINVADVHLSAKAGFYASKYKKFGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEIYPQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVVVLQNFKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEEITDSGSIYVQSDGEHLGFLPRKFQVLPGAIDIIS
What is the function of this protein?
Involved in the production of sphingoid long-chain base (LCB).  Is required for the cold-induced accumulation of phytosphingosine-phosphate, the regulation of the cold-responsive MPK6 and reduction of root growth at moderate low temperature.
What are the official names of this protein?
Sphingoid long-chain bases kinase 2, mitochondrial, AtLCBK2, LCB kinase 2.
Protein: HPCL4_BOVIN
Sequence: MGKTNSKLAPEVLEDLVQNTEFSEQELKQWYKGFLKDCPSGILNLEEFQQLYIKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSVTSRGSFEQKLNWAFEMYDLDGDGRITRLEMLEIIEAIYKMVGTVIMMRMNQDGLTPQQRVDKIFKKMDQDKDDQITLEEFKEAAKSDPSIVLLLQCDMQK
What is the function of this protein?
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
What are the official names of this protein?
Hippocalcin-like protein 4, Neurocalcin-beta.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
Protein: RPAB1_RAT
Sequence: MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYVLEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRESQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  Pols are composed of mobile elements that move relative to each other.  In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template.  Seems to be the major component in this process (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerases I, II, and III subunit RPABC1, RNA polymerases I, II, and III subunit ABC1, DNA-directed RNA polymerase II subunit E, RPB5 homolog.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZN33B_HUMAN
Sequence: MNKVDQKFQGSVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVGYCAHKPEVIFRLEQGEEPWRLEEEFPSQSFPEVWTADHLKERSQENQSKHLWEVVFINNEMLTKEQGNVIGIPFNMDVSSFPSRKMFCQYDSRGMSFNTVSELVISKINYLGKKSDEFNACGKLLLNIKHDETHTREKNEVLKNRNTLSHRENTLQHEKIQTLDHNFEYSICQETLLEKAVFNTRKRENAEENNCDYNEFGRTFCDSSSLLFHQIPPSKDSHYEFSDCEKFLCVKSTLSKHDGVPVKHYDCGESGNNFRRKLCLSQLQKGDKGEKHFECNECGKAFWEKSHLTRHQRVHTGEKHFQCNQCGKTFWEKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRTHTGEKPYQCNACGKTFYQKSDLTKHQRTHTGQKPYECYECGKSFCMNSHLTVHQRTHTGEKPFECLECGKSFCQKSHLTQHQRTHIGDKPYECNACGKTFYHKSVLTRHQIIHTGLKPYECYECGKTFCLKSDLTIHQRTHTGEKPFACPECGKFFSHKSTLSQHYRTHTGEKPYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKTFCQKSQLTQHQRIHIGEKPYECNECGKAFCHKSALIVHQRTHTQEKPYKCNECGKSFCVKSGLILHERKHTGEKPYECNECGKSFSHKSSLTVHHRAHTGEKSCQCNECGKIFYRKSDLAKHQRSHTGEKPYECNTCRKTFSQKSNLIVHQRTHIGEKPYE
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 33B, Zinc finger protein 11B, Zinc finger protein KOX2.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL9_RUMCH
Sequence: MKVILKQDVKGLGKKEQMVEASDGYARNFLLPKGLAVEATSANVNIMKTKKEAEAQKKEREVAQAKELAKKIKDITVTLKVKAGENGKLFGSITSKDVAEALKTQQKLDIDKKKLVMPDSVKSIGTFDVEVKLYPEINSKFTVKIENL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: PRIB_SALPA
Sequence: MTNRLALSGTVCRAPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIVSGHENQAITHSITVGSRITVQGFISCHKAKNGLSKMVLHAEQIELIDSGD
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).  During primosome assembly it facilitates the complex formation between PriA and DnaT.
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: RPOB_BRUO2
Sequence: MAQTHSFNGRKRVRKFFGKIPEVAEMPNLIEVQKASYDQFLMVEEPSGGRPDEGLQAVFKSVFPIQDFSGASMLEFVRYEFDPPKFDVDECRQRDLTYSAPLKVTLRLIVFDIDEDTGAKSIKDIKEQDVYMGDMPLMTDNGTFIVNGTERVIVSQMHRSPGVFFDHDKGKTHSSGKLLFAARVIPYRGSWLDIEFDSKDIVYARIDRRRKLPATTLLMALGMDGEEILSTFYKTVTYTRDGDNWRIPYSAERFKGMKIISDLVDADTGEVVLEAGKKLTARAAKQLAEKGLKAIKATEDDLFGSYLAEDVVNYATGEIYLEAGDEIDEKVLKTLIDTGETEINVLDIDHVNIGAYIRNTLAVDKNESRQEALFDIYRVMRPGEPPTMDSAEAMFHSLFFDSERYDLSAVGRVKMNMRLDLDAEDTVRVLRKEDILAVVKMLVELRDGRGEIDDIDNLGNRRVRSVGELMENQYRVGLLRMERAIKERMSSIEIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATFARVNKYGFIESPYRKVVDGKVTNDVVYLSAMEEAKHSVAQANVELDEQGGFVDEFVICRHAGEVMMAPRENVDLMDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVRAEAPFVGTGMEPIVARDSGAAIAARRGGIVDQVDATRIVIRATEELDPSKSGVDIYRLQKFQRSNQSTCINQRPLVRVGDRIHKGDIIADGPSTDLGDLALGRNVLVAFMPWNGYNYEDSILLSEKIVSDDVFTSIHIEEFEVAARDTKLGPEEITRDIPNVSEEALKNLDEAGIVYIGAEVHPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSMRMPPGTYGTVVEVRVFNRHGVEKDERAMAIEREEIERLAKDRDDEQAILDRNVYGRLADMIDGKVAAAGPKGFKKGTTITRELMTEYPRSQWWQFAVEDEKLQGELEALRSQYDDSKKLLEARFMDKVEKVQRGDEMPPGVMKMVKVFVAVKRKIQPGDKMAGRHGNKGVVSRILPVEDMPFLEDGTHADIVLNPLGVPSRMNVGQILETHLGWACAGMGKKIGELLDVYRKTANIEPLRQTLEHIYPDNDRNEPVRSYDDDAILMLANQVKRGVSIATPVFDGAVEADINAMLTDAGLATSGQSTLYDGRTGEPFDRQVTMGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYEAIVRGDDTFEAGIPESFNVLVKEMRSLGLNVELDDTREAEQPALPDAAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: MTGA_BACFR
Sequence: MKLRKPFRILRNLILFFFISSIGAVIFYRFVPVYVTPLMIIRSVQQLVSGEKVVCKHTWVPFDKISPSLPMAVIASEDNRFASHNGFDMIEIKKAMKENETRKKKRGASTISQQTAKNVFLWPQSSWIRKGFEVYFTFLIETCWSKERIMEVYLNSIEMGKGIYGAQATAKYKFKTTAAKLTRGQCALIAATLPNPIRFDSAHPSPYIKRRQGQILRLMNLVPKFPPVDKEKAKGQDTKKQKNKKKKK
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: Y1524_MYCBO
Sequence: MQGAVAGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYSRTVSGQLTLLVPFIDRVRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQVTVPQAAVYEISNYIVGVEQLTTTTLRNVVGGMTLEQTLTSRDQINAQLRGVLDEATGRWGLRVARVELRSIDPPPSIQASMEKQMKADREKRAMILTAEGTREAAIKQAEGQKQAQILAAEGAKQAAILAAEADRQSRMLRAQGERAAAYLQAQGQAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPEMARGDANKVWVVPSDFNAALQGFTRLLGKPGEDGVFRFEPSPVEDQPKHAADGDDAEVAGWFSTDTDPSIARAVATAEAIARKPVEGSLGTPPRLTQ
What are the official names of this protein?
Uncharacterized protein Mb1524.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PREX1_HUMAN
Sequence: MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL
What is the function of this protein?
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP.  Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein.  May function downstream of heterotrimeric G proteins in neutrophils.
What are the official names of this protein?
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns(3,4,5)-dependent Rac exchanger 1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Protein: PG159_VACCW
Sequence: MASILNTLRFLEKTSFYNCNDSITKEKIKIKHKGMSFVFYKPKHSTVVKYLSGGGIYHDDLVVLGKVTINNLKMMLFYMDLSYHGVTSSGAIYKLGSSIDRLSLNRTIVTKVNNYDDTFFDDDD
What are the official names of this protein?
Protein OPG159.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG159 protein family.
Protein: SYP_PORGI
Sequence: MAKELKELTPRSESYSQWYQDLVIKADLAENSAVRGCMVIKPYGYAIWEKMQRQLDDMFKETGHVNAYFPLFIPKSFLSREAEHVEGFAKECAVVTHYRLKANPDGDGVVVDPQAKLEEELIVRPTSETIIWNTYKNWIQSHRDLPILCNQWANVVRWEMRTRLFLRTAEFLWQEGHTAHATKEEAEEEARRMLEVYATFAEEYMAMPVVKGVKSANERFAGAVDTYTIEALMQDGKALQSGTSHFLGQNFAKAFNVTFADKDGNRDFVWATSWGVSTRLMGALIMSHSDDNGLVLPPKLAPYQVVIIPIYRNEEQLAQIDEKATQITQALRAKGISVKYDNSDNKKPGWKFAEYELKGIPVRLAMGARDLENNTIEIARRDTLTKETVGLDGIEETVATLLDDIQKNIFQKALNYRKEHTITVDSYEEFKEKIEDGGFILAHWDGTSETEERIKAETKATIRCIPLNGDMTPGKCMVTGKPSPQRVLFARAY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DESA2_MYCTU
Sequence: MAQKPVADALTLELEPVVEANMTRHLDTEDIWFAHDYVPFDQGENFAFLGGRDWDPSQSTLPRTITDACEILLILKDNLAGHHRELVEHFILEDWWGRWLGRWTAEEHLHAIALREYLVVTREVDPVANEDVRVQHVMKGYRAEKYTQVETLVYMAFYERCGAVFCRNLAAQIEEPILAGLIDRIARDEVRHEEFFANLVTHCLDYTRDETIAAIAARAADLDVLGADIEAYRDKLQNVADAGIFGKPQLRQLISDRITAWGLAGEPSLKQFVTG
What is the function of this protein?
May be a desaturase involved in mycobacterial fatty acid biosynthesis.
What are the official names of this protein?
Putative acyl-[acyl-carrier-protein] desaturase DesA2, Putative acyl-ACP desaturase DesA2.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 2 family.
Protein: ENAP2_ARATH
Sequence: METTTPQSKSSVSHRPPLGREDWWSEEATATLVEAWGNRYVKLNHGNLRQNDWKDVADAVNSRHGDNSRKKTDLQCKNRVDTLKKKYKTEKAKLSPSTWRFYNRLDVLIGPVVKKSAGGVVKSAPFKNHLNPTGSNSTGSSLEDDDEDDDEVGDWEFVARKHPRVEEVDLSEGSTCRELATAILKFGEVYERIEGKKQQMMIELEKQRMEVTKEVELKRMNMLMEMQLEIEKSKHRKRASASGKKNSH
What is the function of this protein?
Probable transcription regulator (By similarity).  Promotes histone acetylation during ethylene signaling in an EIN2-dependent manner, thus regulating positively ethylene-responsive genes (By similarity).
What are the official names of this protein?
Trihelix transcription factor ENAP2, Trihelix DNA-binding protein ENAP2, Agrobacterium tumefaciens VirF-interacting protein 5, EIN2 nuclear associated protein 2.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm.
Protein: SYP_PROM5
Sequence: MRVTTSFPLGTLRDTPSEAEIISHQLLLKGGYIRRVNSGIYAYMPIMLKVIEKISNIIEKELNNNGCSKLLLPQLHPAELWKRSERWEGYTAGEGIMFNLKDRQGKEFGLAPTHEEVITNIASEIINSYKQLPLCFYQIQTKFRDEIRPRFGLMRSREFIMKDGYSFHSSKEDLSSFYEKMERSYENIFKNCGLDTVGVDADSGAIGGAASKEFMVTADAGEDYILFTESGSYAANIEKAISLPSKEIPLKSFETEWLETPNQKSIVDICKENDLDASQIVKVVIFVAKFENKSQLPILTCIRGDQHINEIKLFNLISKKYSSNLISLEIIEDNATIEKNLTNFPLGYIGPDINDEVIKNSSSWDKSWIRIADHSANNLSSFVSGSNKVNFHKVFQTFSFIDNQFLISDIRNAKKGDRISLESNEELKEKRGIEIGHIFQLGQKYSEKLNAKFSDKDGKLKNLWMGCYGIGVTRIAQAAIEQNHDENGISWPIQISPFEILIIPTNLKDPYQTKLTEEIYKEFESKKIDVLLDDRDVRAGVKFKDADLIGIPFQIIIGRDSINKEVEFICRSSKRKIKISSQNLLEKFISESKILYNENS
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.