PharMolix/UniProtQA huggingface dataset:
Protein: PURT_CHLPD
Sequence: MQKKIMLLGSGELGKEFVIAVKRLGHFVIAVDSYNDAPAQQVADRREVINMLDGAALDAIVARHQPDVIVPEIEAIRTERFYDYEKEGIQVVPSARAANFTMNRKAIRDLASKELGLRTATYRYAASKEELKRAIGEVGVPCVVKPLMSSSGKGQSTVKTEADIEHAWSYSQSGRRGDSVEVIVEAFVPFHTEITLLTVTQKNGPTLFCPPIGHRQERGDYQESWQPCRIGDAQLHEAQEIAEKVTRSLTGAGIWGVEFFLADDGLYFSELSPRPHDTGMVTLAGTQNFTEFELHARAVLGLPIPKIELLRVGASAVVSADREGKNPDYSGLEEALGEPCTDIRIFGKPATRPYRRMGVTLAYDEPGSDVDTVKAKAIANARKVRVTSE
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: AGO_THET2
Sequence: MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDPRKPIPHLTGLLVPVLTLEDLHEEEGSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV
What is the function of this protein?
First characterized as a DNA-guided RNA endonuclease.  Uses gDNA to bind complementary RNA target strands, resulting in cleavage of the target RNA.  The cleavage site is 10 nucleotides (nt) downstream of the target residue base-paired with the 5'-end of the guide DNA.
What are the official names of this protein?
Protein argonaute, TtAgo.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Long pAgo subfamily.
Protein: GUN16_TRIHA
Sequence: MRYALIASMLGQAAISVAMPSEPAHSPRAAGAQAYASNQAGNYKLTSIAAPVQGNGSPGPSTWNLSIDDTSSGYKQKIVGFGAAVTDATVSAFNELSASTLSQLLDELMTGAGASFSLMRHTIGASDLSGDPAYTYDDNGGNADPGMTGFNLGDRGTAMATMLAQMKGLNSNLQIFGSPWSAPGWMKLNNAIDGNTNNNNLNDGYLTNNGAQYSAAFAQYFVKYIQAFESHGATINAITLQNEPLNSQAGYPTMYMFSYEQGDLIQNYVAPALKAAGLSTKIWAYDHNTDQPDFPEQVMGIAADDVSAVAWHCYATNLDWTVLTNFHNSYPNTDQYMTECWTPSTGAWNQAASFTMGPLQNWARGVAAWTLGTTAQDGPHLSSGGCGTCTGLVTINNGQYTFQTAYYMMAQFSKFMPVGATVLSGTGSYTYSGSGGVQSVASLNPDGTRTVVIENTFGNDIYIHLSTSSGQEWSGNVPTNSVTTWVLPAV
What is the function of this protein?
Has highest activity on the linear beta-1,6-glucan pustulan.  Lower activity against yeast glucan and laminarin (beta-1,3-glucans with beta-1,6-branches).  No activity on colloidal chitin, pachyman, starch, cellulose, nigeran, dextran or gentobiose.
What are the official names of this protein?
Endo-1,6-beta-D-glucanase BGN16.3, Beta-1,6-glucanase BGN16.3, Glucan endo-1,6-beta-glucosidase BGN16.3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 30 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: REPN_STAAU
Sequence: MSKNNHANHSNHLENHDLDNFSKTGYSNSRLNRHTMYTPEPKLSFDAMTIVGNLNKNNAHKLSEFMSVEPQIRLWDILQTKFKAKALQEKVYIEYDKVKADTWDRRNMRVEFNPNKLTHEEMLWLKQNIIDYMEDDGFTRLDLAFDFEYDLSDYYAMTDKSVKKTIFYGRNGKPETKYFGVRDSDRFIRIYNKKQERKDNADIKIMSEHLWRVEIELKRDMVDYWNDCFNDLHILQPDWKTIERTSDRAMVFMLLNDEEEWGKLERRTKNKYKKLIKEISLIDLTDLMKSTLKANEKQLQKQIDFWQREFRFWK
What is the function of this protein?
This protein is probably a specific topoisomerase involved in initiating replication.  This protein is specifically required and may be rate-limiting for replication of the plasmid in vivo.
What are the official names of this protein?
Replication initiation protein.
What is the protein family that this protein belongs to?
Belongs to the plasmid replication initiation factor family.
Protein: VKOR1_RAT
Sequence: MGTTWRSPGRLRLALCLAGLALSLYALHVKAARARNEDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGADSILNQSNSIFGCMFYTIQLLLGCLRGRWASILLILSSLVSVAGSLYLAWILFFVLYDFCIVCITTYAINAGLMLLSFQKVPEHKVKKP
What is the function of this protein?
Involved in vitamin K metabolism.  Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.  Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
What are the official names of this protein?
Vitamin K epoxide reductase complex subunit 1, Vitamin K1 2,3-epoxide reductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the VKOR family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: BUK_LISMC
Sequence: MSFDVLTINPGSTSTKLAVYQGDKVLFEETVRHTMQELADFNNVQEQFDFRWQVLRRVMDAHGYDVKKLQAVVGRGGLLRPVAGGTYMVTEKMIDDLKENKYGEHASNLGALLAKKLADELTIPSFIVDPVVVDEMQEIARISGNAFIARKSIFHALNHKAAGRKIAKELGKDYEKMNFVIAHLGGGISVAAHRQGKAVDVNNALDGDGPFSPERSGSLPMNDFLEACFSGKWTKRELHELIVGRGGMISYLGTNSMLEVEAKVQAGDVKAIEAFDAMAYQVSKEIGACSVVLQGKVDAIILTGGLARSELFTNKIIEQTNWITSVIIEPGEDELEALNSGVQRVLAGLEKEKEY
What are the official names of this protein?
Probable butyrate kinase, BK, Branched-chain carboxylic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_LACPL
Sequence: MGKFEVLDHPLIQHKLTIIREKNCGTKVFREMVNEISTLMAYEVSRDMPLKDIEIETPIAKSTQKTLAGKKVAIVPILRAGLGMVDGFLNMIPAAKVGHVGMYRDEKTLKPVEYFVKLPSDISQRQLFVVDPMLATGGSAIMAMDMLKKRGASNIKFMCLVAAPEGVKALRDAHPDIDVYTAALDDHLNEDGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: NRFA_ECO27
Sequence: MTRIKINARRIFSLLIPFFFFTSVHAEQTAAPATPVTVEAKNETFAPQHPDQYLSWKATSEQSERVDALAEDPRLVILWAGYPFSRDYNKPRGHAFAVTDVRETLRTGAPKNAEDGPLPMACWSCKSPDVARLIQKDGEDGYFHGKWARGGPEIVNNLGCADCHNTASPEFAKGKPELTLSRPYAARAMEAIGKPFEKAGRFDQQSMVCGQCHVEYYFDGKNKAVKFPWDDGMKVENMEQYYDKIAFSDWTNSLSKTPMLKAQHPEYETWTAGIHGKNNVTCIDCHMPKVQNAEGKLYTDHKIGNPFDNFAQTCANCHTQDKAALQKVVAERKQSINDLKIKVEDQLVHAHFEAKAALDAGATEAEMKPIQDDIRHAQWRWDLAIASHGIHMHAPEEGLRMLGTAMDKAADARTKLARLLATKGITHEIQIPDISTKEKAQQAIGLNMEQIKAEKQDFIKTVIPQWEEQARKNGLLSQ
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ATPG_LEPBA
Sequence: MATPREIKKRINSVKNTRKITRTMEMVSTAKAKKATNKVNAAKPYADLTRELVSSLSSLASIIHSPYLRKPDKIRKVAILAIAANRGLCGGFNSNLLRMVKNRIEELKSKGVEVEVHAAGKKAISFFKFAKVELVTSYTNIDDKAGSKEANDLASYFMERFANESVDSVEIISTHYYSAANQKPETTTVLPLQMEETGSKGSSGPEVLYEPDPKTILENLLPMVIKTTFVKIILESVASEHIARRVAMKAATDAAGEMIKLLTRGYNRVRQAKITQEISEIVGGAEAIS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS15_ENDTX
Sequence: MTFEKKTVVDQFKVHATDTGSSEVQIAILTTRIKYLSDHFKKFPKDFASRVGFLKMIGQRRQLLDYLKKYNKDSYSSLIKRLYLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: TRHO_SYNSC
Sequence: MNPSNLEPGLANDSRLLVAAFYAFTPLDDERRETLLSSLPTLARNGSVLGSVLVAHEGVNGTISGPESAVDAVLDHLRTSFDLGDEHYARLEVKRSWAEKPVFRRFKARRKKEIVTIGVASVDPSTSVGTYVEAEHWNALVDDPDTLVIDTRNSYETAIGTFEGAIDPSTESFRDFPQWAESTLRPLIEQKSSKRIAMFCTGGIRCEKASSYLQQQGFGEVHHLRGGILKYLEQVPEAESRWQGECFVFDQRVALNHQLEPGEHSLCHACGLPVSAQQRELPSYIKGVQCLHCVDRFSDADRERFAMRQRQIDQRQIEQHKINRQQG
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: PGPP1_ARATH
Sequence: MQTPSMAASTTSYYPIPKSFLLSPPRHKRNPNLISCSTKPICSPPPPSSSSSSPLQTTTTHRSQKQNLRLPTFEDSFLLYQFSSPTEDPGFSNRIPEQFDGEPRELVLPRVEDNNKGLAISSNMWWADLKAALGQRINIEGIVSSVSVVVKDRQFVLPHVSVKDLRYIDWEVLKRKGFKGVVFDKDNTLTAPYSLAIWPPLRPSIERCKAVFGHDIAVFSNSAGLTEYDHDDSKAKALEAEIGIRVLRHRVKKPAGTAEEVEKHFGCTSSELIMVGDRPFTDIVYGNRNGFLTVLTEPLSRAEEPFIVRQVRRLELALLKRWLRKGLKPVDHSLVSDITQFVKVPSDL
What is the function of this protein?
Phosphatidylglycerophosphate (PGP) phosphatase involved in the biosynthesis of phosphatidylglycerol (PG), a phosphoglycerolipid predominantly present in chloroplastic thylakoid membranes and which has important photosynthetic function; seems to use PGP 34:3, PGP 34:2 and PGP 34:1 as substrates (PubMed:27541283, PubMed:27614107, PubMed:29476828).  Required for thylakoid membranes development and chloroplast function (PubMed:27541283, PubMed:27614107).  Necessary for normal cell growth (PubMed:27614107).  Required for root growth and columella cells organization (PubMed:29476828).
What are the official names of this protein?
Phosphatidylglycerophosphate phosphatase 1, chloroplastic/mitochondrial, AtPGPP1, PGP phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast. Mitochondrion. Note=Localized in chloroplast of leaf mesophyll cells, but in mitochondrion of root cells.
Protein: TIKI1_HUMAN
Sequence: MSPWSWFLLQTLCLLPTGAASRRGAPGTANCELKPQQSELNSFLWTIKRDPPSYFFGTIHVPYTRVWDFIPDNSKEAFLQSSIVYFELDLTDPYTISALTSCQMLPQGENLQDVLPRDIYCRLKRHLEYVKLMMPLWMTPDQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTEVDIKSRGVPVLDLFLAQEAERLRKQTGAVEKVEEQCHPLNGLNFSQVIFALNQTLLQQESLRAGSLQIPYTTEDLIKHYNCGDLSSVILSHDSSQVPNFINATLPPQERITAQEIDSYLRRELIYKRNERIGKRVKALLEEFPDKGFFFAFGAGHFMGNNTVLDVLRREGYEVEHAPAGRPIHKGKSKKTSTRPTLSTIFAPKVPTLEVPAPEAVSSGHSTLPPLVSRPGSADTPSEAEQRFRKKRRRSQRRPRLRQFSDLWVRLEESDIVPQLQVPVLDRHISTELRLPRRGHSHHSQMVASSACLSLWTPVFWVLVLAFQTETPLL
What is the function of this protein?
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins.  Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.  Able to cleave WNT3A, WNT5, but not WNT11.  Required for head formation.
What are the official names of this protein?
Metalloprotease TIKI1, TRAB domain-containing protein 2A.
What is the protein family that this protein belongs to?
Belongs to the TIKI family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NRN1_BOVIN
Sequence: MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGGGNGAAGPLLPALPVLLVSLSAALATWLSF
What is the function of this protein?
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
What are the official names of this protein?
Neuritin.
What is the protein family that this protein belongs to?
Belongs to the neuritin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Synapse.
Protein: RL13_BURP1
Sequence: MKTFSAKAHEVTREWYVIDATDKVLGRVASEVARRLRGKHKPEFTPHVDTGDFIIVINASKLKVTGNKTLDKKYYRHSGYPGGIYETTFGKMQERFPGRALEKAVKGMLPKGPLGYAMIKKLKVYAEATHPHSAQQPKALEI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: GFCE_ECO57
Sequence: MKKNIFKFSVLTLAVLSLTACTLVPGQNLSTSNKDVIELPDNQYDLDKMVNIYPVTPGLIDQLRAKPIMSQANPELEQQIANYEYRIGIGDVLMVTVWDHPELTTPAGQYRSASDTGNWVNADGAIFYPYIGRLKVAGKTLTQVRNEITARLDSVIESPQVDVSVAAFRSQKAYVTGEVSKSGQQPITNIPLTIMDAINAAGGLTADADWRNVVLTQNGVKTKVNLYALMQRGDLRQNKLLHPGDILFIPRNDDLKVFVMGEVGKQSTLKMDRSGMTLAEALGNAEGMNQDVADATGIFVIRATQNKQNGKIANIYQLNAKDASAMILGTEFQLEPYDIVYVTTAPLARWNRVISLLVPTISGVHDLTETSRWIQTWPN
What is the function of this protein?
May be involved in polysaccharide transport.
What are the official names of this protein?
Putative polysaccharide export protein GfcE, Group 4 capsule protein E homolog.
What is the protein family that this protein belongs to?
Belongs to the BexD/CtrA/VexA family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: PLSB_SHEB8
Sequence: MPKHDSLWLKSLRWIQKHLVHTIVVPQDPFADLNLDASRPLAYVMKTESLSDIAALSEITAKLGLPSPYEPLVANGVIAPRVVCLQGRKPLFGERAGNEPFLECFMRLLAVHKERPELDIQLVPVSLYWGRTPGKEDDTMKAAVFERENPTWLRKCLMILFLGRHNFVQFSNAVSLRYMADEHGTDMGIAHKLARVARVHFRRQRKVMTGPVLPNRQALFHSLLKSESLRKAIQEEAANKKISETQARETAIEYLDEIAADYSDSLVRIAERFLTWLWNKLYSGINIKGAEQVRQLHHDGHEIVYVPCHRSHMDYLLLSYILYYQGMVPPHIAAGINLNFWPAGPMFRRGGAFFIRRSFNGNKLYTAVFREYLDQLFAKGYSVEYFSEGGRSRTGRLLAPKTGMIAMTMNSVLRGIERPVTLVPVYLGYDHVMEVATYHKELSGKKKKKESVWQVFGAIRKLGNFGQGYVNFGEPITLQNFLNERAPNWRTELADDPEQKPSWLTPAVNVLANRVMTNINDAAAASSVTLTSLVLLATDQNALERSLLERQLDLYLTLLKKVPYTTYTSVAEGDGKHLVQQGLELNKFVVCADPLGEIVSIEASQAVSMTYYRNNIIHLFIVPSLIASCLTHNEQIPRQQVVSIVADFYPLLKAELFMGIKDVPAYVNQVLDFFIEQGLVVETDTLTVVPEHTSQLLLLASSVSETLQRYAIIFNLLANRPKMERSELESESHLLAQRLGALHGITAPEFYDKKLYGTLSVKLKELGYLADNQDKSNINRIRDQANSLLRPSVKQTIVASVTAEHTV
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NRAM_I90A1
Sequence: MNPNQKIITIGSVSLGLVVLNILLHIVSITITVLVLPGNGNNGSCNGTVIREYNETVRIEKVTQWHNTNVIEYIERSESDHFMNNTEALCDAKGFAPFSKDNGIRIGSRGHVFVIREPFVSCSPTECRTFFLTQGSLLNDKHSNGTVKDRSPYRTLMSVEIGQSPNVYQARFEAVAWSATACHDGKKWMTIGVTGPDAKAVAVVHYGGIPTDVINSWAGDILRTQESSCTCIKGECYWVMTDGPANRQAQYRAFKAKQGKIIGQAEISFNGGHIEECSCYPNEGKVECVCRDNWTGTNRPVLVISPDLSYRVGYLCAGLPSDTPRGEDSQFTGSCTSPMGNQGYGVKGFGFRQGNDVWMGRTISRTSRSGFEILKVRNGWVQNSKEQIKRQVVVDNLNWSGYSGSFTLPVELTKRNCLVPCFWVEMIRGKPEEKTIWTSSSSIVMCGVDHEIADWSWHDGAILPFDIDKM
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: MSRA_PSEAB
Sequence: MVLRSEILTKKSELPTPDQALPGRESAMPVPEAHFVNGRPLTAPFPAGLQQVLFGMGCFWGAERRLWQQPGVWVTAVGYAGGYTPNPTYDEVCSGLTGHSEVVLVVYNPQETSFEQLLKVFWEAHDPTQGMRQGGDIGTQYRSVIYTFDAAQKAAAMASRENFQAELAKAGYDRITTEIADVPPFYYAEAYHQQYLAKNPNGYCGLGGTGVCLPA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: PDXH_SHIFL
Sequence: MSDNDELQQIAHLRREYTKGGLRRRDLPADPLTLFERWLSQACEAKLADPTAMVVATVDEHGQPYQRIVLLKHYDEKGMVFYTNLGSRKAHQIENNPRVSLLFPWHTLERQVMVIGKAERLSTLEVMKYFHSRPRDSQIGAWVSKQSSRISARGILESKFLELKQKFQQGEVPLPSFWGGFRVSLEQIEFWQGGEHRLHDRFLYQRENDAWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: GPDA2_MYCPA
Sequence: MAAQMREPKVVVLGGGSWGTTVASICARRGPTLQWVRSRETADDINENHRNSRYLGNDVVLSDTLRATTDFCEAANTADVVVTGVPSHGFRGVLTELARELRPWVPVVSLVKGLEQGTNMRMSQIVEEVLPGHPAGILAGPNIAREVAEGYAAAAVLAMPDQHLATRLSGLFRTRRFRVYTTDDVVGAEMAGALKNVFAIAVGMGYSLGIALVIARALREMTKLGVAMGGSPDTFPGLAGLGDLIVTCTSQRSRNRHVGEQLGAGKPIDEIIASMNQVAEGVKAASVIMEFGLTMPIAREVDAVINHGSTVEQAYRGLIAEVPGHEVHGSGF
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase 2 [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDK8_AEDAE
Sequence: MDYEFKMKTQQERAKVEDLFEYEGCKVGRGTYGHVYKAHRKESNDTKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKATKKPVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIRKMPEHHTLTKDFKRSNYANCSLVKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDPYFSEDPMPTADVFAGCPIPYPKREFLTDEDQDDKGESKRQQQQQQQQQANQQAQQNQQQQANHQNQQQNQQQQANQQNQQSQQQQQQQQMQQQQQAQAGGMDHSAAKRVRMSGPNGQPGNGMNQQDYQVQQAQQAAAAAAAAQQQQQQQQQQQMMFNNQQQGGFQQRY
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.  Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit Cdk8, Mediator of RNA polymerase II transcription subunit Cdk8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RHOH_BOVIN
Sequence: MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVLMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKNKWIGEVRSNLPCTPVLVVATQTDQREVGPHRASCVNAIEGKRLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRRFFSINECKIL
What is the function of this protein?
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.  Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF.  Inhibits activities of RAC1, RHOA and CDC42.  Negatively regulates leukotriene production in neutrophils.  Negative regulator of hematopoietic progenitor cell proliferation, survival and migration.  Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70.  Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways.  Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling.  Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection.  Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction.  Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells.
What are the official names of this protein?
Rho-related GTP-binding protein RhoH.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Colocalizes together with ZAP70 in the immunological synapse.
Protein: RS18_STRSV
Sequence: MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKILPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: HEMH_ECO81
Sequence: MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALEMAPEKVMMTFQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.