PharMolix/UniProtQA huggingface dataset:
Protein: GATC_CLOBJ
Sequence: MSVSKKDVEYVAELARLEFKEEEKDNFVNDLNKILNYMEKLDELNTDDVDIVVNPYYIENKYREDNVEKSMELKEVIDNAPESLEEYVIVPKVID
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: GLPK_CAEEL
Sequence: MVLLAAIDQGTSSSRFLVFEADTGELVTSHQIEVRQLFPHGGWVEMDPMELYDTVVSCISKTIEKLENLGISADEIKSVGVANQRETSIVWDKETGKPLYNAIVWLDTRTSSLADEAISRTASKSKDEFRAKTGLPIHPYFSALKLKWLFQNVPEVKKAYADGNLMFGTVDTWLIWKLTGAYVTDVSNASRTLLLDLHKRKWSTQLCEFFDLPIEILPEIRSSAEVYGHFDKGPLEGVPLSGCLGDQQAAMVGHQCLNAGQTKNTYGTGTFMLCNIGTRPIISKNGLLTTVGFQFGADSPVVYALEGSGSIGGNVVRFLRDNFKFISDAKEMEGLCRSVEDTSGAYFVPSFTGLYTPYWDSTARGTILGLTQVTQREHICLAALRAVAFQSAEMIAAVEQDLEGGTKVTTLKVDGGMIANKLFNEIQADIMGRDIVTPKITEISGWGAAVAGGIGAQQISLDEFLQQSSEDNRYTPQKDDNWRSAELARWKEAVKRSCGWAQ
What are the official names of this protein?
Probable glycerol kinase, GK, Glycerokinase, ATP:glycerol 3-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: MANB_MYCPN
Sequence: MNSNAYLEAQRWLSHPRVKPNLKEVITAMSAEEIEHFFSLKKPSFGTAGVRGKMAPGYHGMNVFSYAYLTQGYVNYIQSLNPTKKPLRFLVARDTRKHGALFNGIVCDVITSMGHVVYMFDNNEPTPTPLVSYVIKKYHFDGGVNVTASHNPKTDNGFKIYDGHGAQLLDFQTDQLIAMLPPVVTMLDFEPRGNNELLHFLDNEVVYKNYFDDLKESLVVDNDSFKNLPVVFTGLHGTSVKLLPRFLTYLGYSNIISVQPQNVFDANFANADHLNPESKDTWELARQYASNTKAKLMMAIDPDADRFAIAEWNPQTQDWHYFSGNESGVMVAYYKLKHKQFKRQPYIVTTVVSTDLVDKIAKKYGAFVKRTNVGFKFIGQAVNHFSKDNELVVAFEEAIGMMASDGLNREKDSFQAAAIMLEIARYCHNKGISLLEFYRGEIFGEFGDYYNWTVPHTIHGVNWKEKMEQVLHQLTTATIKEVVGHKITKIKNYVDINLVEYVLENGNWIKFRISGTEPKLKLYFNLSNGYLAALKHEAKKMHEFLVRLLNLDKA
What are the official names of this protein?
Phosphomannomutase, PMM.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MNME_SALNS
Sequence: MSHNDTIVAQATPPGRGGVGILRISGLKARDVAQEVLGKLPKPRYADYLPFKDVDGSALDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTLPGVRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNGVIADLDAVRTEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLRDASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPADIWPDFIARLPKNLPITVVRNKADITGETLGISEVNGHSLVRLSARTGEGVDVLRNHLKQSMGFDTNMEGGFLARRRHLQALAEAAEHLEQGKAQLLGAWAGELLAEELRLAQQSLSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_STRSV
Sequence: MSVSFENKETNRGLLTFSISQEKIKPALDRVFNSVKKDIAVPGFRKGRLPRAIFNQRFGEEALYQDALNALLPEAYEAAVKEAGIEVVAQPQFDVESMEKGQDWVIKAEVVTKPEVKLGAYKDLEVTVEATKEVTDAEVDERIERERNNLAELVLKEGPAADGDTVVIDFVGSVDGVEFDGGKGDNFSLGLGSGQFIPGFEEQLVGHSAGETVDVVVTFPEDYQAEDLAGKEAKFVTTIHEVKEKEVPALDDELAKDIDEEVETLDELKEKYRKELSEAKETAYKDAVEAAAIDQAVANAEIVDLPAEMVHEEVHRAVNEFLGNMQRQGISPDMYFQITGTTQEDLHKQYEADAESRTKTNLVVEAVAKAEGFEASAEEIEAEVTSLASDYNMEVERVRQLLSEDMLKHDIAIKKAVELITSTAKVK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RL20_MYCAP
Sequence: MRVKGGTVTRARRKKWIKLAKGYFGHKSIGYKVAKQAVVKSWTYAFRDRKQVKRDYRKLWISRISAAVRLEGLSYSKFINGLKKSNITINRKMLSELAINEPQVFSQLIAIARDSE
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: FTSKL_NOSS1
Sequence: MLEMYINNNNTEFQKQQLWTAIVQAKQDGLSNEEIIENVQEALPDAMVFYAETVLKQIDFRAKLSRPVVEFNLEFLFQVIYESVIAGTNDNEILSICAEHCTLNQYEFVRYALEYIHLHRMPSQWEQNNVYQKMIEIVSSSPIESLFEYIESIKNIYLKQIGYELVQENLYNLLLNNKPISYFTDLANQSKDKFIKNYCCRTAVLVARATGKPLDLKVTGDGSIILKETKYLNSEIANNGIVSSNILTMGQAGKLLVDTLEDFNINAKYVDAKNGPTFNRIRVKLERGVSYKKVEDIGNDLVQQLGEELGLKVAPMVSVVPGGVVFDIPRLDRQFAYFRDYFSFDGEPDIYSVSIPGGVDVDGTYVEIPLYSDNVTHILGGGRTRGGKSQFEKAAILYLVRRYPPSVVRLALSDVKRVTFGKFDGLPHLVAPVARDAESTANLLDYLVEEMELRYQEFERHSSIETIAQYNSRFAPDCIMPRVICLIDECFDLLSDDNYCDRIETALMKLLAKAGGAGIHVLLYTQRPDKNVIDPLIRSNFPAKTAFVTTRPEDSCIILGDDKDKRAVYLLGYGDFLYKTTEVLRLQALYVADDEDPEYFQQLLLEAKNQNDPYTAWKSGLDFDEFVASLYDESSSNDNGKFKATTATKTKQSKTDFEGSFSFKVQLDEEARNSIMNLHQKGYQLDEIVKAVFNLSRQDGRSYKKFRNVVEEFLNNFKGGGEDDI
What is the function of this protein?
Probable DNA motor protein.  May track DNA in a ATP-dependent manner by generating positive supercoils in front of it and negative supercoils behind it (By similarity).
What are the official names of this protein?
Uncharacterized FtsK-like protein all7666.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
Protein: GP161_MOUSE
Sequence: MDFVQHALLTASRGALTMSLNSSLSYRKELSNLTATEGGEGGAVSEFIAIIIITVLVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHQEPGYTIFWQIWCALFPFLIMLVCYGFIFRVARVKARKVHCGTVVTVEEDSQRSGRKNSSTSTSSSGSRRNALQGVVYSANQCKALITILVVIGAFMVTWGPYMVVITSEALWGKNCVSPTLETWATWLSFTSAICHPLIYGLWNKTVRKELLGMCFGDRYYRESFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQSLGHSSSTGDTGFSYSQDSGTDVMLLEDGTSEDNPPQHCTCPPKRRSSVTFEDEVEQIKEAAKNSLLHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLFTARTVPGAGFGGRRGSRTLVNQRLQLQSIKEGNVLAAEQR
What is the function of this protein?
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development.  Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling.  In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling.  Its ligand is unknown.
What are the official names of this protein?
G-protein coupled receptor 161.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex- dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded.
Protein: TAL1_GIBIN
Sequence: MSSSLEQLKATGTTVVSDSGDFVSIGKYKPQDATTNPSLILAASKKAEYAKLIDVAIDYAKQKGGSIDQQVDDALDRLLVEFGKEILKIIPGKVSTEVDARYSFDTEASVNKALHLIELYGEQGISKDRILIKIAATWEGIKAAEILQRDHGINTNLTLMFSLVQAIGAAEAGAYLISPFVGRILDWFKASTKKEYSKEEDPGVQSVKTIFNYYKKYGYNTIVMGASFRNTGEITELAGCDYLTISPNLLEDLLNSNEPVPKKLDASQAASLDIEKKSYINDEALFRFDFNEDQMAVEKLREGISKFAADAVTLKSILKEKLA
What is the function of this protein?
Important for the balance of metabolites in the pentose-phosphate pathway.  Involved in xylose fermentation to ethanol.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
Protein: PROF2_PARJU
Sequence: MSWQAYVDDHLMCDVGDGNTLASAAIIGHDGSVWAQSANFPQLKPEEVTGIMNDFNEGGFLAPTGLFLGGTKYMVIQGESGAVIGKKGSGGATLKKTGQAIVIGIYDEPMTPGQCNLVVERLGDYLLEQGM
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin-2, Pollen allergen Par j 3.0102.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RSMH_RICB8
Sequence: MQQPHIPVMLNEMLKFLAPKAGESYLDCTFGAGGYSKALLENCDCYVTALDRDPNVIKKAEEIKHNYKDRFDFVETNFGNCFAKLESKKFDGIVLDLGVSSMQLDIPDRGFSFLHDGPLDMRMSGQGLSAEEFINTAEEKDLADVIYKYGDETFSRRIAKKIVEVRKAARIDSTGKLADIVHSCIGFRKGKIDPATKTFQAIRIYINNELGELEQFLANVKNILKKDGRLVVVSFHSLEDRIVKNFFKENSEKPVARSKYAKEDIMLNPDKWLKIITNKAEIPSDKEISLNVRARSAKLRAAKKI
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_LATSS
Sequence: MRTIATYQNQSVLVLGLGKSGVNATKLLLQLGAKVTVNDGQDQEDTPAVAELRALGATVITGSHPVALFEEGFHYLFKNPGIRYDNPMVAEAIKREIPVLTEPELAYEVSEADWVSVTGSNGKTTTTTLIALMLNYQRAQGHAYAAGNIGIPLSEVAQKATAKDTMVTELSSFQLMGTTTVKPKVAVLTNIYEAHLDYHGTRENYVQAKMRIVQNQTASDYFVVNWDLPELRTLSQQTKAQVVPFSRLGTSEEGAYVKDGQLCFKGEVIMPVTDINVPGDHNVENALAALAAAKLMGQSNEAIIEVLTTFTGVKHRMQFVKEFAGRRFYNDSKATNMEATEVALKSFKQPIVLIAGGLDRGFTFEPLTDLLKAHVKAIILYGETKQLLAQTAKEAGIETIEIVDQLTEAVPAAYAASQEGDVILLSPACASWDQFKTFEERGDVYIDAVEQITE
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPG_VIBPA
Sequence: MSETVSQNKETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDASDKLRFQALSNPDLYEGNADLGVKLSFDESANTLTISDNGIGMSRNDVIEHLGTIAKSGTAEFFSKLSEEQSKDSQLIGQFGVGFYSAFIVADAVTVRTRAAGLPADEAVQWHSAGEGEYTIENITKESRGTDIILHMRDEGKEFLNEWRLRDVISKYSDHIGIPVSIQTVVRDEDGKETDEKKWEQINKAQALWTRNKADISDEEYQEFYKHVSHDFADPLVWSHNRVEGKNDYTSLLYIPSKAPWDMMNRDHKSGLKLYVQRVFIMDDAEQFMPSYLRFVRGLIDSNDLPLNVSREILQDNKVTQSLRNACTKRVLTMLERMAKNDEEKYQSFWKEFGLVLKEGPAEDFANKEKIAGLLRFASTEVDSAEQTVGLASYVERMKEGQDKIYYLTADSYAAAKNSPHLEQFKAKGIEVILMFDRIDEWLMNYLTEFDGKQFQSITKAGLDLSKFEDEADKEKQKETEEEFKSVVERTKSYLGDRVKDVRTTFKLASTPAVVVTDDYEMGTQMAKLLAAAGQAVPEVKYIFEINPEHELVKRMADEADEEAFGRWVEVLLGQAMLAERGSMEDPTQFLGAINKLLTKV
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBA1_OTOCR
Sequence: MVLSPTDKSIVKAAWEKVGAHAGDYGAEALERMFLSFPTTKTYFPQFDLSHGSAQVKGHGKKVADALTNAVLHVDDMPSALSALSDLHAHKLTVDPVNFKLLSHCLLVTLACHLPAEFTPAVHASLDKFMASVSTVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-A, Alpha-A-globin, Alpha-I, Hemoglobin alpha-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: IL6_TAKRU
Sequence: MASISYLLAPLVLAAVLQPTAGAPLDAPTESPAGETSGEEAETGSPDDALAVALESVLGATKLHKNEFLVEFQGEVKYDFLDRYKIPSLPAKCPYSNFGKDACLRRLLEGLLIYSVLLKRVEEEFPSSSILSEVRFYSNILIKELENKVRDRDQVMRLTSSQEEQLLKDTDYPDTFHRKMTAHGILYNLHYFLVDCRRVINKRAKHRESAGSRVVRAVTFYHPKKRS
What is the function of this protein?
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism.  Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway.  The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'.  Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
What are the official names of this protein?
Interleukin-6, IL-6.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DODA_AMAMU
Sequence: MVPSFVVYSSWVNGRQRYIRQAFASILFYIIRDTTLSFPSHTTMSTKPETDLQTVLDSEIKEWHFHIYFHQNNAAEHQAALELRDAVLRLRQDGAFVAVPLFRVNMDPMGPHPVGSYEIWVPSETFASVFSYLCMNRGRLSILVHPLTREELRDHEIRNAWIGPSFPLNLANLPIKSDEIPLQYPSLKLGYSSTAHKMSLEERRKLGDDIEAVLRGEKEAARAPHRDA
What is the function of this protein?
Extradiol dioxygenase that opens up the cyclic ring of DOPA between carbons 4 and 5 thus producing an unstable seco-DOPA that rearranges non-enzymatically to betalamic acid.  Can also catalyze the formation of muscaflavin (a pigment found in the hygrocybe mushrooms family and of some amanita species only) by a 2,3-extradiol cleavage of DOPA.
What are the official names of this protein?
DOPA 4,5-dioxygenase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL71_PARTE
Sequence: MSQKKQKIQVEQKVPENVAKKTQRDSKLRDAVAKRRTERLAANKTRRAQWEKTAQAYEAEYKAADKSLVDNLRKAKTEGGFYVPAEAKLILVVRIRGINTLNPQVRQTLRLLKLRQLHNAAFVRVNKATIEMIRKVEPYVTYGYPSRAVIKNLIYKRGYAKINGQRIPITNNNVIEQQLGKVGIHSVEDLIHEITTVGPHFKEANRFLWAFKLRGPRGGFIAKRKSFINQGDWGNREDLINDLVKRMI
What is the function of this protein?
Binds to G-rich structures in 28S rRNA and in mRNAs.  Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity).
What are the official names of this protein?
60S ribosomal protein L7 1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: ATPA_GEOSL
Sequence: MEIRAEEISEIIRKQIKEYGKEVEVAETGTIISVGDGIARIHGLDKAMAGELLEFPGGVSGMVLNLEEDNVGAAILGEDNENIKEGTTVKRTGRIVEVPVGEALIGRVVNAIGQPIDGKGPINTTTFGKVEVKAPGIVKRKSVHQPMQTGLKAIDSMVPIGRGQRELIIGDRQTGKTAVAIDTIINQKGGDLICIYVAIGQKRSTVAQVVSKLQEYGAMDYTIVVSASASEPAPLQFIAPYTGVTMGEYFRDNGKHALIIYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDCGAGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLESDLFYSGVRPAINVGLSVSRVGGSAQVKAMKQVAGTLRLNLAQYREMAAFAQFGSDLDKATQMQLARGERLVEILKQPQYRPIPNEKQVLVIFAANNGFVDEYPVSSLRRYESELYSFFDSRKADILAELRDKKAIDDDLKAKMIAALEELKKEFTA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: USO1_RAT
Sequence: MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTDRSDSEIIAYALDTLYNIISNDEEEEVEENSTRQSEDLGSQFTEIFIKQPENVTLLLSLLEEFDFHVRWPGVRLLTSLLKQLGPPVQQIILVSPMGVSKLMDLLADSREIIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIITEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKAWFEVGDENPGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGIPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNEKGQGEIVATLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQGNATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLENYTKEKLKQLIEKRIGKENYIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELKQQVSTLKCQNEQLQTAVTQQASQIQQHKDQYNLLKVQLGKDNHHQGSHSDGAQVNGIQPEEISRLREEIEELRSHQVLLQSQLAEKDTVIENLRSSQVSGMSEQALATCSPRDAEQVAELKQELSALKSQLCSQSLEITRLQTENSELQQRAETLAKSVPVEGESELVTAAKTTDVEGRLSALLQETKELKNEIKALSEERTAIQKQLDSSNSTIAILQTEKDKLYLEVTDSKKEQDDLLVLLADQDQKILSLKSKLKDLGHPVEEEDESGDQEDDDDELDDGDRDQDI
What is the function of this protein?
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane (PubMed:7831323, PubMed:7831324, PubMed:10679020).  May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (PubMed:7831323, PubMed:7831324, PubMed:10679020).
What are the official names of this protein?
General vesicular transport factor p115, Protein USO1 homolog, Transcytosis-associated protein, TAP, Vesicle-docking protein.
What is the protein family that this protein belongs to?
Belongs to the VDP/USO1/EDE1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Note=Recycles between the cytosol and the Golgi apparatus during interphase.
Protein: RF1_LACCB
Sequence: MDKIFEQLDGLLDRYEELQELMSDPEVISDTKRYLALSKEEGGMRDVVAAYKKYKQVLSDIKESEEVLRESKDDDMEALAKEDLEDLQKQKADLEDQIKVLMLPKDPNDDKNIIMEIRGAAGGDEASLFAGDLLNMYMHYAERQGWKTEIIDATPTEVGGYKEVVVMITGDNVYSKLKYENGAHRVQRVPVTESAGRVHTSTATVGVMPEYDEVDLKIDPKDIRTDVYRSSGAGGQHVNKTSSAVRMTHIPSGIVVSMQDERSQQENRARAMQILRSRVYDYYETQNQEKYDQNRKNAIGTGDRSERIRTYNYPQNRVTDHRIGLTLNKLDRIMNGELDEIIDALIVHDQAQKMESLNV
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NBL1_YEAST
Sequence: MIPALTPEERQKLRSAILHRMQLELETTEKLIENIKEETLKKLNLLQQPDATSAPQSKELIREVLEQEGRRIE
What is the function of this protein?
Component of the aurora kinase complex, also called chromosomal passenger complex (CPC), essential for chromosome segregation and metaphase chromosome alignment.  Mediates the SLI15-BIR1 interaction within the CPC.
What are the official names of this protein?
N-terminal-borealin-like protein.
What is the protein family that this protein belongs to?
Belongs to the borealin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Note=In G1, localizes along nuclear microtubules and at spindle poles. In late S phase to metaphase, is seen as a few small nuclear foci and also localizes diffusely within the nucleus. Also found along the spindle in early anaphase, at the spindle midzone in late anaphase, and finally concentrated at the plus ends of depolymerizing microtubules before mitotic exit.
Protein: IF2G_HUMAN
Sequence: MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD
What is the function of this protein?
As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis.  In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation.  The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing.  This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP.  Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome.  In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity).  Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 2 subunit 3, Eukaryotic translation initiation factor 2 subunit gamma X, eIF-2-gamma X, eIF-2gX.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: TRM5_LEIIN
Sequence: MPAKQSRSTAESRTAPHSYRERVNSTVELAALVYRPLTASGALLSILRGKLYRRRSVRNVLDVVAVHSISGGQGHSAESKVRVEYLAPAEGNANGNSISNIGAAPCADIQGSSDIAATGNSLSTPAQPALLEGRCKMCLLDPTVLKATELWPDPASAAQHRVPVFSLGAAIAGSHVTQQLEAALQAGQLSRKAADLLQQLHERLSRGPSSVSLTEDRDGSEQPQGSPRAAAAPPPPSSKRRASYTGAVEVTFTPRAVELNYQAYTMSELLSMVLPLREHADLVALSGFEQVGHIAHVNLSAAHLPYADIIGQVILDCNETVSVVVNKVDAISSVFREFKMDIIGLRCRTDGVDGNAVAGADLDEFGEAGGSLTAAERQAIALEALSPTYSLAEARIHRLLTATVRQHGCSFRVPYNRVYWNSRLSFEHTRLVDRMGPGDMLFDVMAGVGPFAVPAAKKGVQVFANDLNPVAAQYMKVNAELNHLPANSLRVFNMDGRDFLNSVLFDSVTRAADAPFPGHLCTGRRHVTMNLPAIAVEFLDVFQPLSSTCASASGQQCNASAAAIVNERWNHLPAHVDPNAIDRCTLFHVYCFSAAEDLITDAVRQVEVNLGYTLPPENIEETLMVRDVAPTKRMMCVSFTLPPAFWENLLASRPGQGEEPRGAHAETASTLVEEEEVEQAAKKAKTDKM
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.