PharMolix/UniProtQA huggingface dataset:
Protein: SDHAB_XENLA
Sequence: MALLKVAPSRLLSRALQLTSTLQNCTATSIAARRNFHFTVYGRKDTSAKVSDSISTQYPVVDHDFDAVVVGAGGAGLRAAFGLSEAGFNTACITKLFPTRSHTVAAQGGINAALGNMEDDDWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVIELENYGMPFSRTEQGKIYQRAFGGQSLKYGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCMEDGSIHRFRAKNTVIATGGYGRTYFSCTSAHTCTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSEGERFMERYAPVAKDLASRDVVSRSMTIEMREGRGCGKDKDHVYLQLHHLPPSQLASRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVITHVNGEDRVVPGLYACGEAASASVHGANRLGANSLLDLVVFGRACALSIAEECKPGEALPSIKENAGEESVANLDKLRFANGSTRTSELRLNMQKTMQTHAAVFRTGSVLKEGCEKLSVINSAMDDLKTFDRGIVWNTDVVETLELQNLMLCALQTINSAEARKESRGAHAREDYKTRIDEYDYSKPIQGQQKKSFSEHWRKHTLSYVDSKGKVSLEYRPVIDATLNEDCASVPPAIRSY
What is the function of this protein?
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial, Flavoprotein subunit of complex II B, Fp.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RL5_PSEPW
Sequence: MARLKEIYRNEIAPKLKEELKLSNVMEVPRVTKITLNMGLGEAIGDKKVIEHAVADLEKITGQKPVVTFARKSIAGFKVREGWPIGVKVTLRREKMYEFLDRLLAISLPRVRDFRGLNAKSFDGRGNYSMGVKEQIIFPEIDYDKIDALRGLDITLTTTARSDDEGRALLRAFKFPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RECO_GRAFK
Sequence: MLIHTKAIIISALKYGEADLIVKAYTLSDGLCTYMLKGVLKSRKGKFKASMFQSLTQLEIVANHRGGGKMEYLKEAKVTGNYQSLHTHPIKLAMVMFLAEMLRNAIREEESNEPLFHYLEYSFQFLDSTDKIANFHLLFLLNLTRYLGFQPEMGIKDLPVFNLLDGIFQDFSSNDYCIEGKNVDLLKSFLGTDFDALQYIKMNQTSRNDFLSMLLLYYELHIEGFRKPKSLSVLNEIFG
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RXT2_YEAST
Sequence: MTIRSSMKNNAELESKSVLANESNIISTFTRRIIKEKSGNYQVLKRSLDGKLIYPEATGISSNRGNKLLQRSEVVTRRDLNNSKPMIEQTVFYNGSEHRLLQTNIVTDSRRKRIKFTPDINVEPVLVGDENDIDGSEKEDENITDEYYGEEDDDDLSKLVNVKEILTPILSLGDIINHKTISRTFSSPILKNLALQIILMIEKEQMSVVRYSQFLEVFLGDHPEPIYESNLNLPSYNHNLTLPEDRGASDEDDINNKNNINEVNSNSLSTEAGHINNGMEEFGEEDPFFALPRLEQSNALLSLLPSSSGSASISTLTAAEQQQLNEEIESARQLSQIALQRNKEFIRNLQKIRKSVIKANRIRGRILNWSREYLGISDDDITIPVALRVVKRGLISATTNKTTNFEEEIENTMEDGVVDDNEPDEEANRA
What is the function of this protein?
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
What are the official names of this protein?
Transcriptional regulatory protein RXT2.
What is the protein family that this protein belongs to?
Belongs to the RXT2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COF1B_XENLA
Sequence: MASGVMVSDDVVKVFNDMKVRHQLSPEEAKKRKKAVIFCLSDDKKTIILEPGKEILQGDVGCNVEDPYKTFVKMLPRNDCRYALYDALYETKETKKEDLVFVFWAPEEASLKSKMIYASSKDAIRKRFTGIKHEWQTNTYDDINDPCNLADKLGGNTVVSLEGKSLRS
What is the function of this protein?
May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity).  Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity.  Required for formation of the cleavage furrow during cytokinesis.
What are the official names of this protein?
Cofilin-1-B, ADF/cofilin-2, XAC2.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.
What are the subcellular locations of this protein?
Nucleus matrix. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Membrane. Note=Cellular localization varies throughout development and may be related to phosphorylation levels. Shows diffuse cortical cytoplasm localization in oocytes, with membrane-association increasing after fertilization, particularly in the vegetal hemisphere.
Protein: SYL_STAAM
Sequence: MNYNHNQIEKKWQDYWDENKTFKTNDNLGQKKFYALDMFPYPSGAGLHVGHPEGYTATDIISRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTKKNIQTFKRQIKELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEVIDGVSERGGHPVYRKPMKQWVLKITEYADQLLADLDDLDWPESLKDMQRNWIGRSEGAKVSFDVDNTEGKVEVFTTRPDTIYGASFLVLSPEHALVNSITTDEYKEKVKAYQTEASKKSDLERTDLAKDKSGVFTGAYAINPLSGEKVQIWIADYVLSTYGTGAIMAVPAHDDRDYEFAKKFDLPIIEVIEGGNVEEAAYTGEGKHINSGELDGLENEAAITKAIQLLEQKGAGEKKVNYKLRDWLFSRQRYWGEPIPVIHWEDGTMTTVPEEELPLLLPETDEIKPSGTGESPLANIDSFVNVVDEKTGMKGRRETNTMPQWAGSCWYYLRYIDPKNENMLADPEKLKHWLPVDLYIGGVEHAVLHLLYARFWHKVLYDLGIVPTKEPFQKLFNQGMILGEGNEKMSKSKGNVINPDDIVQSHGADTLRLYEMFMGPLDAAIAWSEKGLDGSRRFLDRVWRLMVNEDGTLSSKIVTTNNKSLDKVYNQTVKKVTEDFETLGFNTAISQLMVFINECYKVDEVYKPYIEGFVKMLAPIAPHIGEELWSKLGHEESITYQPWPTYDEALLVDDEVEIVVQVNGKLRAKIKIAKDTSKEEMQEIALSNDNVKASIEGKDIMKVIAVPQKLVNIVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_CLOBH
Sequence: MYTTGLIGKNINYSESPEIHNNYYKKNNIPFFYKIFNLKQDQIDDFIKNLHKNNIKGFNVTIPYKETILQYLNDIVYPADKIGAVNTVAVQEDKLIGYNTDYIGFIKSLQYYNIQVKNFKCLIIGSGGSAKCIYYALKELNARDICIVSRNPEKARLKFEKKVKILNIKDENKLDRYDLIVNCTPIGGPNLKEQKPIELKEIKKNCVVYDLNYTPKRSKLLKEAKENGAFIINGEKMLIFQAYSAIGLWCLNGIKGGR
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: DNAA_NITWN
Sequence: MSDTEQERWSRVKGRLRSTVGEDIYSSWFARMDLESVHGESVRLSVPTRFLKSWIQAHYAERVLSCWQAELPDVHRIDLTVRSAMRCAAPVREAPATDARHPERSEGRNGVELKTVATAPASANHDALGGSPLDPRLTFQSFVTGRSNTLAHAAARQVAEGRRGDSVMFNPLYIHAGVGLGKTHLLQAVTWAGNAGTERRVLYLTAEKFMYGFVAALKTQTALAFKEALRGIDVLVIDDLQFLQGKSTQAEFCHTLNALIDAGRQVVIAADRPPSDLESLDDRVRSRLAGGLVVEMGSLGEELRLGILRSRVEAARVHHASFDVPEPVLDYLAKAITHNGRDLEGAINRLLAHSKLNAQPVTLEMAEREVRDLVRPQEPRRIKIEDIQRVVARQYNVSRSDLLSSRRTANVVRPRQVAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRKIEALVSKDTTLSDEVELLKRQLQE
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGAL_COFAR
Sequence: MVKSPGTEDYTRRSLLANGLGLTPPMGWNSWNHFRCNLDEKLIRETADAMVSKGLAALGYKYINLDDCWAELNRDSQGNLVPKGSTFPSGIKALADYVHSKGLKLGIYSDAGTQTCSKTMPGSLGHEEQDAKTFASWGVDYLKYDNCNNNNISPKERYPIMSKALLNSGRSIFFSLCEWGEEDPATWAKEVGNSWRTTGDIDDSWSSMTSRADMNDKWASYAGPGGWNDPDMLEVGNGGMTTTEYRSHFSIWALAKAPLLIGCDIRSMDGATFQLLSNAEVIAVNQDKLGVQGNKVKTYGDLEVWAGPLSGKRVAVALWNRGSSTATITAYWSDVGLPSTAVVNARDLWAHSTEKSVKGQISAAVDAHDSKMYVLTPQ
What is the function of this protein?
Preferentially cleaves alpha-1,3 and alpha-1,4 glycoside linkages.  Involved in the hydrolysis of the galactomannan, it splits alpha-linked galactose moieties.  It is particularly suitable for the hydrolysis of guar gum to a gum with improved gelling properties.  Can cleave terminal alpha-1,3-linked galactose residues responsible for blood group B specificity from the surface of erythrocytes thereby converting these cells serologically to group O.
What are the official names of this protein?
Alpha-galactosidase, Alpha-D-galactoside galactohydrolase, Melibiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
Protein: RL9_RIPO1
Sequence: MSKRVQIVLNKTINKLGQTGDLVEVAPGYARNYLIPQGMGVIATPGILRQVEQRKEKEMQRLLAEKQAAEARKVALSTIGRFTIRKQVGEGEAIFGTVTTQEVADAIQAATNQEVDRRGITLPEISQTGFYKATVKLHPEVTAEIEIQVAPL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: CKP2L_HUMAN
Sequence: MVGPGPTAAAAVEERQRKLQEYLAAKGKLKSQNTKPYLKSKNNCQNQPPSKSTIRPKNDVTNHVVLPVKPKRSISIKLQPRPPNTAGSQKPKLEPPKLLGKRLTSECVSSNPYSKPSSKSFQQCEAGSSTTGELSRKPVGSLNIEQLKTTKQQLTDQGNGKCIDFMNNIHVENESLDNFLKETNKENLLDILTEPERKPDPKLYTRSKPKTDSYNQTKNSLVPKQALGKSSVNSAVLKDRVNKQFVGETQSRTFPVKSQQLSRGADLARPGVKPSRTVPSHFIRTLSKVQSSKKPVVKNIKDIKVNRSQYERPNETKIRSYPVTEQRVKHTKPRTYPSLLQGEYNNRHPNIKQDQKSSQVCIPQTSCVLQKSKAISQRPNLTVGRFNSAIPSTPSIRPNGTSGNKHNNNGFQQKAQTLDSKLKKAVPQNHFLNKTAPKTQADVTTVNGTQTNPNIKKKATAEDRRKQLEEWQKSKGKTYKRPPMELKTKRKVIKEMNISFWKSIEKEEEEKKAQLELSSKINNTLTECLNLIEGGVPSNEILNILSSIPEAEKFAKFWICKAKLLASKGTFDVIGLYEEAIKNGATPIQELRKVVLNILQDSNRTTEGITSDSLVAETSITSVEELAKKMESVKSCLSPKEREQVTATPRIAKAEQHNYPGIKLQIGPIPRINGMPEVQDMKFITPVRRSSRIERAVSRYPEMLQEHDLVVASLDELLEVEETKCFIFRRNEALPVTLGFQTPES
What is the function of this protein?
Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells.
What are the official names of this protein?
Cytoskeleton-associated protein 2-like, Radial fiber and mitotic spindle protein, Radmis.
What is the protein family that this protein belongs to?
Belongs to the CKAP2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle pole. Note=Uniformly distributed along each microtubule bundle of spindles in addition to centrioles during mitosis, expression promptly diminishes at interphase.
Protein: Y1419_STACT
Sequence: MAVNLQEHAHKLEDALRNSEEYKAIKDAYDKVKAHEESKKLFDEFRETQLKFQQMQMQGEQIEEEDLKKAQEQAQAIEKDENIAELMAAEQQMSQVFQEINQIIVKPLDEVYAD
What are the official names of this protein?
UPF0342 protein Sca_1419.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: ASAH1_MOUSE
Sequence: MRGQSLLTWVLAAAVTCAQAQDVPPWTEDCRKSTYPPSGPTYRGPVPWHTINLDLPPYKRWHELLAQKAPALRILVNSITSLVNTFVPSGKLMKMVDQKLPGMIGSLPDPFGEEMRGIADVTGIPLGEIISFNIFYELFTMCTSIITEDEKGHLLHGRNMDFGIFLGWNINNNTWVVTEELKPLTVNLDFQRNNKTVFKATSFVGYVGMLTGFKPGLFSLSLNERFSINGGYLGILEWMFGRKDAQWVGFITRSVLENTTSYEEAKNTLTKTKIMAPVYFILGGKKSGEGCVITRERKESLDVYELDPKHGRWYVVQTNYDRWKNTLFIDDRRTPAKKCLNHTTQKNLSFATIYDVLSTKPVLNKLTVFTTLMDVTKGQFESHLRDCPDPCIGW
What is the function of this protein?
Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:9653654, PubMed:11829492).  Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:9653654).  Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity).  Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity).  For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity).  Has also an N-acylethanolamine hydrolase activity (By similarity).  By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity).  Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (PubMed:10974027).  By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity).
What are the official names of this protein?
Acid ceramidase, AC, ACDase, Acid CDase, Acylsphingosine deacylase, N-acylethanolamine hydrolase ASAH1, N-acylsphingosine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acid ceramidase family.
What are the subcellular locations of this protein?
Lysosome. Secreted. Note=Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent.
Protein: SNX4_DEBHA
Sequence: MSSDDQFTSIQWDRDELGPNKETKVNKQETITEDDEHHNNDNEDKDNDTTKSNEPENIQEDDETKDDNEPTDSLILSKTGDENISNIESQNEGDHIVGEPDVNQEPSSDSQTEAYEINVVVTSPLRDLDSSSKPYISYLLTTATNHPSVMKLSTVKKEQGKEVVEITARRRYGDFRFLFDCLSNDHPEVMMPPLPSKSNFKYLTGDTFSTEFVHKRLHSLDRFVRFITCHKVLSQSSIFHLFVSDSADWSTFQKNLKISKVGVQESDADKGNSSMTSNVVNKVVNEDLLTETIMNFLTPSKHKRETNKEILEISDKLKKLYENLIKLDKIFTKLNKKNHDLSVDYEQFSQQIMKLSVIQNSSDETNEPTTPEINEQKQFATNFKVFASSLSYFSDNWSNLHKYIDESFLVSLKDCAKYIISLTNLIELQHNKKIDLQVLQDYLNKAKSELQGLGGSHNAPPNPIITHNNGGIVNNTTQLIRDTLSTSATPNIGSSVTESKVTKLQNRITELENEISVQSQLVLDLTNKIINEEYPNWDKFNKIELKESLLGLCNEEISFYKGLVDNWSDIELKLLKRLDELK
What is the function of this protein?
Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells.  Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), autophagy, mitophagy, and pexophagy.
What are the official names of this protein?
Sorting nexin-4, Autophagy-related protein 24.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Preautophagosomal structure membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures. Associates to phosphatidylinositol 3-phosphate, necessary for peripheral membrane localization to the perivacuolar punctate structures.
Protein: SFSA_SINMW
Sequence: MKFTGPLVPATLVQRYKRFLFDAILTDGTAITGSCPNTGSMRGLTTPGSRIWLSEHDSTTRKYRHMLEIVEADGTLVGINTGLPNRIAEEAISAGQVSNLDSYDTLRREQRYGRNSRIDILLSDAEKGLAYVEVKNVHFSRLSGLAEFPDSPTERGAKHLEELGDMVAAGHRAIMLYLVQRDDCSRFRICRELDPVYARAFERASTRGVEAYAVKCQVSPLQIVATGPMMVDEAVPAVL
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: RS15_CHLL2
Sequence: MSLTKENKSNIITQFGGAVQNTGKAEVQVALFSGRITDLTGHLQKHPKDKHSRRGLLMLVGKRKKVLNYLKNVDIDRYRKVIADLDLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: CYSD_AERHH
Sequence: MDRERLTHLQQLEAESIHIIREVAAEFENPVMMYSIGKDSSVMLHLARKAFYPGKIPFPLLHVDTDWKFKEMIKFRDETARKYGLDLIVHKNPDGLAMGINPFVHGSGKHTDIMKTEGLKQALNKYGFDAAFGGARRDEEKSRAKERVYSFRDKSHRWDPKNQRPELWRVYNSQVNKGESIRVFPLSNWTELDIWQYIYLENIDIVPLYFAAMRPVVERNGIKIMVDDERMPIGPEDEVKQELVRFRTLGCYPLTGAIESAATTLPEIIEEMLLTTSSERQGRLIDHDQAGSMEQKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: NOS3_SHEEP
Sequence: VAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFRYQP
What is the function of this protein?
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway.  NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).
What are the official names of this protein?
Nitric oxide synthase, endothelial, Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, eNOS, NOS type III, NOSIII.
What is the protein family that this protein belongs to?
Belongs to the NOS family.
What are the subcellular locations of this protein?
Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Cell membrane. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
Protein: SPEB_SALPB
Sequence: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHHRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLSAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPHHSVQIGIRTEFDKDNGFTVLDACQVNDRGVDDILAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: DNAJ_AZOSB
Sequence: MSKRDYYEVLGVNRDAGDDEIKKAYRKLAMKYHPDRNPDSKEAEEKFKEAKEAYEVLSDAQKKGAYDRYGHAGVDPSMGGGGGGQGFEGFADAFGDIFGDLFGGRGGGGGRSNVYRGADLRYNLEISLEEAARGAEKTIRIPTVEECGTCHGSGAKPGTQPKTCPTCGGAGQVRIQQGFFSIQQTCPKCHGTGRIIPDPCGDCGGAGRVKKQKTLEVKIPAGIDEGMRLRHSGHGEPGVNGGPPGDLYVEIHIRQHPVFERDHDDLHCEMPISFATAALGGEIEIPTLEGMARIKIPAETQSGKVFRLRGKGIKNVRSHTHGDLMCHVVVETPVNLTERQKELLREFEEVSKGDAERHNPKAKSWMDKVRDFFAT
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_THEKO
Sequence: MAFDRQKLVEAVKEAKARAKPRNFTQTVEMAVNLKDVDLRKPENRFKLEVVLPHGRGKEPKIAVIADGAVAEAAKKLGLDVISGEELEELAKSPRQARKLAKKYDFFIAAAPLMPKIGRYLGRYLGPRNKMPVVVPPTMTNLEPIVEKLKKTVRIQLKNNPVVHAPIGTEDMDDEKLAENAEAVLNAIINKLERGENQVKSVYIKTTMGPAVKVER
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: ILVC_CLOBB
Sequence: MTKMYYEEDTDLNLLKGKTIAVIGYGSQGHAHALNAKESGGNVIIGLYEGSKSWAKAEAQGFEVFSTAEAAKKADIIMILINDELQAAMYKKDIAPNLEAGNMLMFAHGFNIHFDQITAPNDVDVTMIAPKGPGHTVRSEYQLGKGVPCLVAVHQDATGRALETALAYANAIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETLVEAGYDERNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGSKIITEETKKTMKKVLKDIQDGTFAKDFLLDMSEAGGQAHFKAMRKLAAEHQSEAVGSEIRKLYCWNNEDKLINN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: PGLZ_BACCH
Sequence: MNTKEINRVLQDTFNKELTEGKKRHIVFWYDEAGEFIEDIDELNLEGVRIWKLTPHNMFATKLEVEKNDVNSNFLIYANMAKPSAREDWLLDVYKYSQEFATDKMTVMMRELGITNDAALRDVFKKYTKFFKSKEREALFKSFSVPEYTEEQIDLVVLASLCKCNIVNLDEVIKALFREQLKETNKYWENIRKFGNEETFWNLVEKTYGYNLQDKSINSLLIFFLLTNVSETLSGDIPKTWQPYISAIPMNAIVFMNQFMNHSADEVIYNELANTVEKQVKVTEHLQSKEIKDYITSDTFCCFDTNIITYITKQLMNAIHDYTSYIEIIAARRKLHWFSVFRNEYEALYQAIQLFQQIYEMGNAITESQPFDLFKAYESKYHNIDTAYRKFYVAFDQIEDKDGFRALRDKVENIYTNVYINDLAIKWSDALEGEQEEYWPIAGLESQHTFYRSFVQPFVNKEERVFVIISDALRYEVAKELSNMLNVERKASTDIVAMQGVLPSYTDLGMATLLPYKSITFNENAEVYVNDYKASSTENRATILSKHYKDSTAIQYKDLAAMNRQQFRDVFSGKKVSYIYHNVIDARGDHAATEHEVFHAVEQTLKDIRSLVDQLINTVSASNIVITADHGFIYNRDTLQASDKVKKDFLNTDIEKRRFIISSESNSIEGTMNFSMDYVLGEGSGKYVKVPRGANRFAVQGTGANYVHGGAMLQEIVVPVIKFKNDRSKSSKNDVRKVEVKLTSLTRKITNSITYLEFFQTEKIEGKKTPLRLKVYFTDEEGNRISNENIIIADSQSSKPEDRTFKEKFVLKSMTYDKTKKYYLVLEDEEEAVENIYEKVAFPIDIAITNDFGF
What is the function of this protein?
BREX systems (bacteriophage exclusion) provide immunity against bacteriophage.  A core protein of a type 1 BREX system.  This system allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA.  Methylation of bacterial DNA by PglX probably guides self/non-self discrimination.  When the brxA-brxB-brxC-pglX and pglZ-brxL operons are transformed into a susceptible B. subtilis strain (BEST7003) they confer resistance to bacteriophages SPbeta, SP16, Zeta, phi3T and SP02 and partial protection to phages SP01 and SP82G (these include lytic and temperate phage).  They do not protect against phages phi105, rho10 or rho14.  Additionally confers a very slight reduction in efficiency of plasmid transformation.
What are the official names of this protein?
Alkaline phosphatase-like protein PglZ, BREX protein PglZ.
What is the protein family that this protein belongs to?
Belongs to the alkaline phosphatase superfamily.