PharMolix/UniProtQA huggingface dataset:
Protein: DRME_BACP9
Sequence: MLYSTSDKSLVHCSVPQQIFYRAEECMGDEIVGSLLCKENILLCTPRKYIFPHLVLRALNMDETMGFQKRENPSKRAEILVVTNRLEMLAFLETCRVNAERLFQICSNIHQYIGYCNMGDTYFARVYWRHILYHYYEGKLPQDVPLHYIYPVASGYRKFNALSRGNRNILGRKDSQNPTIYVTENLDMLNEQEHSFDYIFVDCSYIKKGLSNLPKSTLLFFDNLLDDRIPYLQKSAVKNYIVDGDCIQNIDENEIQQPMINIEELLHKVSIHSLDVEYVKSSFEQEIERLIHLLDKLRKGKFSRYDTNVAAKLVYILIRLPIGAGLYDLIASMQPYWDTVLGLLQELKDSESRYENDSFEEMVSLFEDILYKHSLDRSNPKGDELKAFILNEVKQGKSVCVVSNSRKNQLALKEFISLAMGMTIEELAEYDLQFFVSKDIWAQDITVHCDSLVMYSAINFRDLQSLLKISYKRAKLYLYSSEINLITQKLKTILEAENYALRHFVQNSTQQDSTNFYRYLYNRFNKFARQKVIGLNSAAADLLEKSTTVSPAVYRGEKDYKGTDAVKATLVHFTDGSVSFFTKNSAVYVLDNKNKRVTHKHFHEIGLKDTILFVDNDARKDLYRIFIQSVDAKDTSKQAYLSIKKWRELYEEKFMEKRMDDDRLFRLMRTAGWNKTTKSVLRNWRTGYSYGPRDREDIMVLGEVLGINTFVEDVQTYYNAMSKIRVERRKASRILNKLIYSSKQVLGNEDSAILARYNLTLEQLNESLVTKSIKEIVSDRMYYIKPAEVGLLYNVDAKE
What is the function of this protein?
Component of antiviral defense system DISARM (defense island system associated with restriction-modification), composed of DrmE, DrmA, DrmB, DrmC and DrmMII.  DISARM is probably a multi-gene restriction module, this subunit has an unknown function.  Expression of DISARM in B. subtilis (strain BEST7003) confers resistance to phages Nf, phi29, phi105, phi3T, SPO1, SPR and SPP1.  Protection is over 10(7)-fold against phi3T, 10(4)-10(5)-fold against Nf, phi29, phi105 and SPR, 100-fold against SPO1 and 10-fold against SPP1.  DISARM does not interfere with phage adsorption, but instead interferes with (phi3T) DNA replication early in its cycle, preventing replication, circularization and lysogeny and probably causes phage DNA degradation (DNA is degraded in SPP1-infected cells).
What are the official names of this protein?
DISARM protein DrmE.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_PROM9
Sequence: MVATPSTSSQTKGVVRQVIGPVLDVEFPAGKLPKILNALRIEAKNPAGQEIALTAEVQQLLGDHRVRAVAMSGTDGLVRGMEAVDTGAPISVPVGEATLGRIFNVLGEPVDEQGPVKTKDTAPIHRAAPKLTDLETKPKVFETGIKVIDLLAPYRQGGKVGLFGGAGVGKTVLIQELINNIAKEHGGVSVFGGVGERTREGNDLYEEFKESGVINADDLTQSKVALCFGQMNEPPGARMRVGLSALTMAEHFRDVNKQDVLLFVDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTDVGELQERITSTLEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLARALAAKGIYPAVDPLDSTSTMLQPSVVGDEHYKTARAVQSTLQRYKELQDIIAILGLDELSEEDRLTVDRARKIEKFLSQPFFVAEIFTGMSGKYVKLEETIAGFNMILSGELDDLPEQAFYLVGNIDEVKAKAEKLKSEK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: FMT_SHESR
Sequence: MKPLNIIFAGTPDFAARHLQALINSHHNVIAVYTQPDRPAGRGKKLTASPVKELAVSHDIPVYQPGSLRKEPAQQELAALNADIMVVVAYGLILPKVVLDTPRLGCINVHGSILPRWRGAAPIQRALWAGDKETGVTIMQMDVGLDTGDMLLKTYLPIEDDDTSATLYEKLAQQGPDALLQALEGLANGTLTAEKQDEALANYAEKLSKEEARLDWSKSATQLWQEVRAFNPWPVSYFEHQGNTIKVWQTQISTTSSNAAPGTIISASKKGIEVATGDGVLTLLSMQLPGKKPLSVADILNARGDWFTPNTRLNNEAQ
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: Y1730_STAA8
Sequence: MADESKFDQFKGNVKETVGNVTDNKELEKEGQQDKATGKAKEVVENAKNKITDAIDKLKK
What are the official names of this protein?
UPF0337 protein SAOUHSC_01730.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: MTPC1_ARATH
Sequence: MGIIRFQILNPTRICRSTIYYMSCRYLPSSSSSSSPLRVSSSSSQKPSFDFSRRWHFGHPDHHQQYQKPGEEGEKIFRLGLTADIGLSVAKALTGYLCGSTAIIADAAHSVSDVVLSGVALVSYRAANVPKDKEHPYGHGKFETLGALGISAMLLATGSGIAWHALDLLSIALSAAPEVIHSGHHHGIDMNHPILALTVTIASISIKEGLYWITKRAGEKQGSGLMMANAWHHRSDAISSLVALVGVGGSILGVNFLDPLAGLVVSTMIVNAGLKTGHQSILELVDAAIPAQQLEPIRQTILQVEGVKGCHRLRGRRAGSSLYLDVHIVVDPFSSVSVAHEVGEYVRRQINLNHPEVSEVFIHIDPAFLQFSCSTKDHDSITKESNICQEIKHVEATVSDIFSSQLSEKLTIKRITPHLLHSKILLQIVVAMPSTMSIQDVMIAAEHAEKEILKAAPNVARVSIQLSLNSE
What is the function of this protein?
Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.
What are the official names of this protein?
Metal tolerance protein C1, AtMTPc1, AtMTP6.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein: KATG_STRAM
Sequence: MSENHDAIVTDAKTEEAGGCPVAHGRAPHPTQGGGNRQWWPERLNLKILAKNPAVANPLGDGFDYAEAFGSLDLPAVKRDIAEVLTTSQDWWPADFGHYGPLMIRMAWHSAGTYRISDGRGGAGAGQQRFAPLNSWPDNGNLDKARRLLWPVKKKYGQSLSWADLLILTGNVALEQMGFETFGFAGGRADVWEAEEDVYWGPETTWLDDRRYSGDRELENPLGAVQMGLIYVNPEGPNGNPDPIAAARDIRETFGRMAMNDEETVALIAGGHTFGKTHGAGPADHVGDDPEAASMEEQGLGWRNSFGTGKGGDAITSGLEVTWTSTPTRWSNGFFKNLFEFEYELEQSPAGANQWVAKDAPEIVPDAHDPSKKHRPKMLTTDLSLRYDPIYEPISRRFYENPEEFADAFARAWYKLTHRDMGPKSLYLGPEVPEETLLWQDPLPEADGEPVDAEDVATLKTKLLESGLSVSQLVSTAWASASTFRGSDKRGGANGARIRLEPQRGWEVNEPDELAQVLRVLEGIQQEFNSGTKKVSLADLIVLGGTAAVEKAAKEAGFQVQVPFTAGRVDATEEHTDAESFEALEPVADGFRNYLGKGNRLPAEYLLLDRANLLTLSAPEMTVLVGGLRVLGANYQKSPLGAFTRTPGSLTNDFFVNLLDLGVTWKSTSEDQTTFEGRDAATGEVKWAGSRADLVFGSNSELRALAEVYASDDAKEKFVHDFVDAWVKVMNLDRFDLV
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: RT21_MOUSE
Sequence: MAKHLKFIARTVMVQEGNVEGAYRTLNRILTTDGLTEVISRRRYYEKPCRRRQRESYETCRRIYNMEMARKINFLMRKNRADPWLGC
What are the official names of this protein?
28S ribosomal protein S21, mitochondrial, MRP-S21, S21mt.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EFEO_ECO57
Sequence: MTINFRRNALQLSVAALFSSAFMANAADVPQVKVTVTDKQCEPMTITVNAGKTQFIIQNHSQKALEWEILKGVMVVEERENIAPGFSQKMTANLQPGEYDMTCGLLTNPKGKLIVKGEATADAAQSDALLSLGGAITAYKAYVMAETTQLVTDTKAFTDAIKAGDIEKAKALYAPTRQHYERIEPIAELFSDLDGSIDAREDDYEQKAADPKFTGFHRLEKALFGDNTTKGMDQYADQLYTDVVDLQKRISELAFPPSKVVGGAAGLIEEVAASKISGEEDRYSHTDLWDFQANVEGSQKIVDLLRPQLQKANPELLAKVDANFKKVDTILAKYRTKDGFETYDKLTDADRNALKGPITALAEDLAQLRGVLGLD
What is the function of this protein?
Involved in Fe(2+) uptake.  Could be an iron-binding and/or electron-transfer component (By similarity).
What are the official names of this protein?
Iron uptake system component EfeO.
What is the protein family that this protein belongs to?
Belongs to the EfeM/EfeO family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS12_BARQU
Sequence: MPTVNQLIRKPRVTPVKRNKVPALQSNPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTSGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGLLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: GON3_SALFO
Sequence: MDLSNRTVVQVVVLALVAQVTLSQHWSYGWLPGGKRSVGELEATIKMMDTGGVVALPEETSAHVSERLRPYDVILKKWMPHK
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Progonadoliberin-3, Progonadoliberin III.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYTC2_MOUSE
Sequence: MAAQALAAQAVASRLQRQEEDIRWLCAEVQRLRDEQLRGPERGQAEGPRLTREVAQLQAENRDLHQRLCGLRLRLAEQRRTEAGRAAAHEPPTQNQEKDTKKKRLKQSEPGREVKQPNFIKERLQLFETLKTDHQLLPATQEKKNTNNVISVRVAGGKTVQGERWKTTPYQVAAGISKELAEHTVIAKVNGVLWDLDRPLEGDSTVELLMFDNEEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRVVSSTELSALENICKTIIKEKQPFERLEVSKDTLLEMFKYNKFKCRILKEKVDTPTTTVYRCGPLIDLCKGPHVRHTGKIKAIKIFKNSSTYWEGNPEMETLQRIYGISFPDSKMMKDWEKFQEEAKSRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNALMDFIREEYHKRNFTEVLSPNMYNSKLWETSGHWQHYSNNMFTFDVEKDTFALKPMNCPGHCLMFAHRPRSWREMPVRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCMVEQIEEEIKGCLHFLQSVYSTFGFSFQLNLSTRPEHFLGEIEIWDEAERQLQNSLVEFGKPWKINPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKNRPVIIHRAILGSVERMIAILSENYGGKWPLWLSPRQVMVIPVGPACENYALQVSKECFEEGFMADVDLDDSCTLNKKIRNAQLAQYNFILVVGEKEKINNAVNVRTRDNKIHGEISIASVIEKLKNLKKSRTLNAEEDF
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.
What are the official names of this protein?
Threonine--tRNA ligase 2, cytoplasmic, Threonyl-tRNA synthetase, ThrRS, Threonyl-tRNA synthetase protein 3.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Also detected at lower levels in the nucleus.
Protein: PETG_ORYSJ
Sequence: MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PI51B_MOUSE
Sequence: MSSTAENGDAVPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRAMRMHLTYDLKGSTYKRRASRKEREKPNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHILDHSLKDKEEEPLQNVPDAKRPGMQKVLYSTAMESIQGPGKSADGIIAENPDTMGGIPAKSHKGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVGEHYPHDRTTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLDLQDDASVLDVYL
What is the function of this protein?
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8798574, PubMed:9367159, PubMed:9535851, PubMed:22942276).  PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity).  Mediates RAC1-dependent reorganization of actin filaments (PubMed:10679324).  Contributes to the activation of phospholipase PLD2 (PubMed:11032811).  Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (PubMed:18772378).
What are the official names of this protein?
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta, PIP5KI-beta, PtdIns(4)P-5-kinase 1 beta, 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta, Phosphatidylinositol 4-phosphate 5-kinase type I alpha, PIP5KIalpha, Phosphatidylinositol 4-phosphate 5-kinase type I beta, PIP5KIbeta.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane. Endomembrane system. Note=Associated with membranes.
Protein: RL14_SYNJA
Sequence: MIQQQTMLTVADNTGARKLMCIRVLGSSGRRYASLGDVIVGVVKDALPNMPVKKSDVVKAVVIRTVDTVRRPDGMCIRFDDNAAVIINDDGNPRGTRVFGPVARELREKNFTKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SPED_SALPB
Sequence: MKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPIDPKLIDQTEHPGPLPETVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDVNGMKHFIDHEINSIQNFMSEDMKSLYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTETERQEITAALWKEMREIYYGRNISAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: DBH1_HALH5
Sequence: MNKTDLINAVAEQAELSKKDASKAVDAVFESITGALKEGGKVQLVGFGSFEVRERSARKGRNPQTGEEIEIPATKNPAFKPGKQLKDAVN
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU-1.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: KA262_LYCMC
Sequence: MKTIFVVILVLFVLSAMLASSPDTTAEAAGCRGNCVTICRDKGKVGGKCYNGKCFCFN
What is the function of this protein?
Inhibits voltage-gated potassium channels.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 26.2, Neurotoxin KTx13.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 26 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ECHA8_MYCTO
Sequence: MTYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELDDDPDIGAIIITGSAKAFAAGADIKEMADLTFADAFTADFFATWGKLAAVRTPTIAAVAGYALGGGCELAMMCDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTMDAAEAERSGLVSRVVPADDLLTEARATATTISQMSASAARMAKEAVNRAFESSLSEGLLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR
What is the function of this protein?
Could possibly oxidize fatty acids using specific components.
What are the official names of this protein?
Probable enoyl-CoA hydratase echA8.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: DPPD_ECOLI
Sequence: MALLNVDKLSVHFGDESAPFRAVDRISYSVKQGEVVGIVGESGSGKSVSSLAIMGLIDYPGRVMAEKLEFNGQDLQRISEKERRNLVGAEVAMIFQDPMTSLNPCYTVGFQIMEAIKVHQGGNKSTRRQRAIDLLNQVGIPDPASRLDVYPHQLSGGMSQRVMIAMAIACRPKLLIADEPTTALDVTIQAQIIELLLELQQKENMALVLITHDLALVAEAAHKIIVMYAGQVVETGDAHAIFHAPRHPYTQALLRALPEFAQDKERLASLPGVVPGKYDRPNGCLLNPRCPYATDRCRAEEPALNMLADGRQSKCHYPLDDAGRPTL
What is the function of this protein?
When a foreign outer membrane heme receptor is expressed in E. coli, DppABCDF can also transport heme and its precursor, 5-aminolevulinic acid (ALA), from the periplasm into the cytoplasm.
What are the official names of this protein?
Dipeptide transport ATP-binding protein DppD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RRF_METS4
Sequence: MATPTFDLADIKRRMQGAVNSLKHDLGSLRTGRASPTLLDPIQVEAYGAAMPMAQVATISVPEPRLLSVAVWDRGMVSAVEKAIRESDLGLNPMTEGQTIRLRIPEMNEQRRKEMVKVAHKYAEEARVAVRHVRRDGLDLLKKLEKDGAISQDDEKRQADQVQKVTDQHIAEVDQTLAAKEKEIMQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLCN4_HUMAN
Sequence: MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN
What is the function of this protein?
Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:18063579, PubMed:28972156, PubMed:23647072, PubMed:27550844, PubMed:25644381).  The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874).  The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874).
What are the official names of this protein?
H(+)/Cl(-) exchange transporter 4, Chloride channel protein 4, ClC-4, Chloride transporter ClC-4.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamily.
What are the subcellular locations of this protein?
Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Localizes to late endosome membrane, lysosome membrane and recycling endosome membrane in the presence of CLCN3.
Protein: PHS_SULIM
Sequence: MSGISSKGLEELKNNGWLILEDGKKIKKEFKFKDFKQSIDFLKDIQPSADALDHHPDVCIYYNRVIVELTTHDMGGLTDLDYKLAIKIDELYKMKTSNL
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: KBL_ECOLI
Sequence: MRGEFYQQLTNDLETARAEGLFKEERIITSAQQADITVADGSHVINFCANNYLGLANHPDLIAAAKAGMDSHGFGMASVRFICGTQDSHKELEQKLAAFLGMEDAILYSSCFDANGGLFETLLGAEDAIISDALNHASIIDGVRLCKAKRYRYANNDMQELEARLKEAREAGARHVLIATDGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVGFVGENGRGSHEYCDVMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNSLAPAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVAQKFARELQKEGIYVTGFFYPVVPKGQARIRTQMSAAHTPEQITRAVEAFTRIGKQLGVIA
What is the function of this protein?
Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
What are the official names of this protein?
2-amino-3-ketobutyrate coenzyme A ligase, AKB ligase, Glycine acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: GLGA_LACAC
Sequence: MRVLFTGAECAPFFKTGGLGDVLGSLPNQLAKEGVDVGVVLPLYQDLPEKYRKNLKYQGNFIVPVGWRNQYCGIFTLKLNGVNYFFIDNEYYFKRPGIYGYYDDGERYAYFQQAVIMMMERFDFIPDVLHCNDYHTAFIPFLLHEKWGFVDAYKGIKTILTIHNLEFQGKYNAKTLPDFFGMNYDWFDSGIVRMDNDVNWMKTGILYADRVTTVSPSYAREIQTVEFGQGLDAILRMCSHKLTGILNGIDFEKYNPKTDPVIKKNYDVYHLHHKSKDKIALQKELDLPIKPNIPLIGMVSRLTAQKGCQLLLDELDNILQFNVQIVILGNGDPYYEHRLMEIAERYPDKLKVILAFDVKLAQRIYAGADSFLMPSAFEPCGLSQLIALRYGTLPIVHEIGGLADTVWVYDETTNEGTGFGFKEFSGYQMVQAIKKMLALYQQKNNWLKIQKIAMKSDFSWKNSADKYKWMYGELIG
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: FAA28_MYCTO
Sequence: MSVRSLPAALRACARLQPHDPAFTFMDYEQDWDGVAITLTWSQLYRRTLNVAQELSRCGSTGDRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQGGVTDERSDSVLSDSSPVAILTTSSAVDDVVQHVARRPGESPPSIIEVDLLDLDAPNGYTFKEDEYPSTAYLQYTSGSTRTPAGVVMSHQNVRVNFEQLMSGYFADTDGIPPPNSALVSWLPFYHDMGLVIGICAPILGGYPAVLTSPVSFLQRPARWMHLMASDFHAFSAAPNFAFELAARRTTDDDMAGRDLGNILTILSGSERVQAATIKRFADRFARFNLQERVIRPSYGLAEATVYVATSKPGQPPETVDFDTESLSAGHAKPCAGGGATSLISYMLPRSPIVRIVDSDTCIECPDGTVGEIWVHGDNVANGYWQKPDESERTFGGKIVTPSPGTPEGPWLRTGDSGFVTDGKMFIIGRIKDLLIVYGRNHSPDDIEATIQEITRGRCAAISVPGDRSTEKLVAIIELKKRGDSDQDAMARLGAIKREVTSALSSSHGLSVADLVLVAPGSIPITTSGKVRRGACVEQYRQDQFARLDA
What is the function of this protein?
Involved in the biosynthesis of phthiocerol dimycocerosate (PDIM), a cell wall-associated lipid found only in pathogenic mycobacteria.  Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase Mas for further chain extension.
What are the official names of this protein?
Long-chain-fatty-acid--AMP ligase FadD28, Acyl-AMP synthetase, Long-chain fatty acid adenylyltransferase FadD28.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: PYRR_NOSS1
Sequence: MATPAKVIEILSAEDLRRTLTRLASQIVERTRDLSQLVLLGIYTRGVPLAELLARQIETLEGINVGVGALDITFYRDDLDQIGLRTPAKTSITLDLTGKTVVLVDDVIFKGRTIRAALNAVNEYGRPEVIRLAVLVDRGHREVPIHPDFVGKQLPTAKEEVVKVYLQDWDGRDAVELVGY
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: RPOA_LATSS
Sequence: MIEFEKPNITKVDESTNYGKFVVEPLERGYGTTLGNSLRRILLASLPGTAVTDIQIDGVLHEFSTIDGVLEDVTQIILNIKKLALKLHVEEDKTIEIDVKGPATVTAADIISDDDVEVLNTDQYICTVAEGGNFHVRMTVKKGRGYVAAVQNKSDDMPIGVLPIDSIYTPISRVNYQVESTRVGRRNDFDKLTLDVWTNGSISPREAISLAAKIMTEHLAIFVDLTDEAKNAEIMVEKEETHKEKMLEMTIEELDLSVRSYNCLKRAGINTVQELTDKSEADMMKVRNLGRKSLEEVKNKLFDLGLGLRTEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.