PharMolix/UniProtQA huggingface dataset:
Protein: EFG_COXB1
Sequence: MATAREIPLNRTRNIGIMAHIDAGKTTTTERVLYYTGVSHKMGEVHEGSAVMDWMEQEQERGITITSAATTCYWLGMDQQYPKHRINIIDTPGHVDFTIEVERSLRVLDGAVAVFCSVGGVEPQSETVWRQANRYHVPRLGFVNKMDRAGANFLRVVNQVKDRLNANPIPIQLPIGAEEDFKGVIDLIREKAIYWNEADRGRTYELADIPEDMKAEVQKWREKMIEAAAESSEELMDKYLEAGDLSPEQIRQGLRQRTLANEIVPILCGSAFKNKGVQALLDAVIDYLPSPTDVPAIRGEEDDGSEGSRSASDDEPFAALAFKIASDPFVGTLTFFRVYSGILKSGDSVYNPIKGKKERIGRLLQMHSNSREEIKEVRAGDIAAAVGLKTVTTGDTICNQQNIITLEKMDFPEPVISVAIEPKTKADQEKMGVALGKLAQEDPSFRVHTDEESAQTIIEGMGELHLEIIVDRMRREFNVEANVGKPRVAYRETIRRSIEQQGKYIRQTGGRGQYGDVWLRIEPREPGAGFEFENAIVGGVVPREYIPAVEKGVREQMENGIRAGYPVVDVKVTIFEGSYHDVDSSEMAFKIAGSMAFKEGASKADPVLLEPIMKVEVVTPEEYMGDVVGDLNRRRGMIQGMDESPAGKIVDVEVPLAEMFGYATDLRSLSQGRATYTMEFLKYAEAPSNIAEAIIKQQS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y716_STRM5
Sequence: MEPLDTLNLWMERARDRARAISFGRFLWHRFLDDRLFQAAAALAYTTVFALVPLAIVVFGVLSAFPVFDRWSDQLSDYVFSNFVPNAARAAEGYLRQFSASAGQLTAAGFIALVVSLLITLNSVEETFNQIWRVGSTRPKLTRFLVYWTVLTLGAMLAAASLAVSARVFAMPLFGTQEGRWLADLALRLAPILIEFVCITLMFRVVPHHTVKWRHAVPGAILAAVILELVKWGIGAYLGSFQSYQKLYGTVAFVPILLLWIYLCWVAVLLGASLSSSMAAFRYQPVELRLPQGYEFYGLLRLLGRFHHARAKGKGLADDEILRLEPMLTDSLLQDLACNLQEIGLLRRDERGEWLLARDLEQVSLSDLYECTQLRIPVAEQHLPYRDDTLGRVALAALDDLRLPLRERLKRKVSDIYTDSGDTP
What are the official names of this protein?
UPF0761 membrane protein Smal_0716.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLPX_LACE2
Sequence: MAGRNIDEKLRCSFCNKTQDQVKKLIAGHNGVYICDECVEICSDILDEEFETEADAKEVVDGMNINLLKPKQIKEFLDDYVIGQDEAKKVLAVAVYNHYKRIMSQSDLDVELQKSNILMLGPTGSGKTFLAQNLARLLNVPFAIADATTLTEAGYVGEDVENILLKLIQAADYDVEKAQYGIIYIDEIDKITKKSENVSITRDVSGEGVQQALLKILEGTIASVPPQGGRKHPQQELIPIDTTNILFICGGAFDGLEKIIESRMDKSSIGFNSELKEKSNDDVGEMFHKALPQDLIKFGLIPEFVGRVPVVVSLDSLDEEALVRILKEPKNAIIKQYQALFGLDEVALEFTDEAVEAVAHKSFERKTGARGLRSILESVMNEVMYEIPSDETISKCIITKEAVEGSAKPLLEYRTDAVKKAQ
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: PHO18_ARATH
Sequence: MKFGKEYVAQMIPEWQQAYMDYTCLKTILREIKTSQKRSESQGVLKRKLSGRRNFSGLTKRYSRTFSSRDLENHDIMVHATTGDDGFEKYETTILKVSEVGRESELVFFKTLDLEFDKVNRFYRSNVEELVKEAVVLNRQMDALIAYRIKLDQPSTSWSCSETVSVDINALDSKEQKGKTLAEEMGIKVEENVSNGGDSTKETAPEALSVLDRIRLNKNQENPLSTIRNVLKLSNKEDIKFTKENLKKIEERLKNVFIEFYRKLRHLKNYSFLNTLAISKIMKKYDKIALRNAAKLYMEMVDKSYLTSSDEINKLMLRVESIFVEHFAGSNRSKGMNLLRPKVTKEKHRITFSTGFFVGCTVSLVIALGLFIHARNIMGAVGHKLYMETMFPLYSLFAFVVLHMIMYASNIYFWKRYRVNYPFIFGFKEGTELGYGHVLLLSFGLGTLALCAVLVNMDMEMDPNTNDYKTITELVPLFVVALVIAISVCPFNIFYRSSRFFFLMVLFRCIAAPLYKVNLPDFFLADQLTSQVQALRSLEFYICYYGWGDFKQRQSTCKSSDVYSTFYFIVAVIPYWSRFLQCVRRLIEEKDVSQGFNALKYLLTIVAVCLRTAFSINRGNDWKIAAWVFSGLATFYGTYWDIVYDWGLLHRPSKSWLREKLLVPHKSVYYVAMVVNVVLRLAWLQTVLDFNISFLHRETMVALIAILEIIRRGIWNFFRLENEHLNNVGKFRAFKSVPLPFNYDEEEDRDS
What is the function of this protein?
May transport inorganic phosphate (Pi).
What are the official names of this protein?
Phosphate transporter PHO1 homolog 8, Protein PHO1 homolog 8, AtPHO1;H8.
What is the protein family that this protein belongs to?
Belongs to the SYG1 (TC 2.A.94) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MNMC_CAMFF
Sequence: MITFRGDGLYNSKFDDIYFNTNEPLIECEHTYSSVLDEINAKFIVVAEAGFGTGLNFFSTVLKFLSLNSTELHYIAVEKYPFKKSELREIYLKFEILKPFFDEFIEQYEILDGALIRIKLLNERVILDLYFGDILDAFDELSFRADAWYLDGFSPTKNPDMWSKEVFDRLSKFCKNRAKVRTFSSAKIVQNRFLEHGFSIKKLKGHYKKREILEASLEHSSPKILKEPWYALPNISKFSDVLIIGAGVAGLAAAFKFKKAGFNVCIAEKMSEAATNGSSNLAGILMPLITKPKVALGNMHMSAFLFARHFYANSPFADFCGVYDYGVNDLEKTRLSLWDSEIFKFENDFEPYPRAFIKSAAQIRPKELCMSLASEFDIKYGYEFESIEKSTGGYVVKFKNSKNIFSSLVIFAMGDVSTNLFQNVFADEFMQLSSVRGQVTHLNKVLNLNSAFSARGYMCKDVRGIQVVGATYDRNDNRSAARATDDEKNIDSLSEFITNLDVKVVGSNVGFRGYSGDRFPIVGAVHNASEFKKIYKSLLWTKHSKNNEFAVHHENILISSAHGSRGLGTAIFGAEILLDIALNRPVCTTNSILNSLNPARFLVRKLKRGLVR
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BACH_HALS3
Sequence: MSITSVPGVVDAGVLGAQSAAAVRENALLSSSLWVNVALAGIAILVFVYMGRTIRPGRPRLIWGATLMIPLVSISSYLGLLSGLTVGMIEMPAGHALAGEMVRSQWGRYLTWALSTPMILLALGLLADVDLGSLFTVIAADIGMCVTGLAAAMTTSALLFRWAFYAISCAFFVVVLSALVTDWAASASSAGTAEIFDTLRVLTVVLWLGYPIVWAVGVEGLALVQSVGVTSWAYSVLDVFAKYVFAFILLRWVANNERTVAVAGQTLGTMSSDD
What is the function of this protein?
Light-driven chloride pump.
What are the official names of this protein?
Halorhodopsin, HR.
What is the protein family that this protein belongs to?
Belongs to the archaeal/bacterial/fungal opsin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RASF2_MOUSE
Sequence: MDYTHQPALIPCGQDKYMPKSELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISWGLRRPIRLQMQDDHERIRPPPSSSSWHSGCNLGAQGTTLKPLTMPTVQISEVDMPVEGLETHSPTDSRGLKPVQEDTPQLMRTRSDVGVRRRGNVRTSSDQRRIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQRLKSSDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVEKLMRKYTVLRLMIRQRLEEIAETPETI
What is the function of this protein?
Potential tumor suppressor.  Acts as a KRAS-specific effector protein.  May promote apoptosis and cell cycle arrest.  Stabilizes STK3/MST2 by protecting it from proteasomal degradation (By similarity).
What are the official names of this protein?
Ras association domain-containing protein 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.
Protein: CH60_SHEDO
Sequence: MAAKEVKFGNDARVKMLAGVNILANAVKVTLGPKGRNVVLDKSFGSPVITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQSIVVEGLKAVAAGMNPMDLKRGIDKAVIAAVAELKKLSQECSDTKAIAQVGTISANSDESIGEIIATAMEKVGKEGVITVEEGQALENELEVVEGMQFDRGYLSPYFINKPETGSIELDSPFILLVDKKISNIRELLPILEGLAKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVAILTGGTVIAEEIGLELEKATLEDLGTAKRVVITKDNTTIIDGSGEHTQITSRVAQIKQQMEDSSSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALVRVASMIADIEVLNEDQKHGVVIALRAMEAPLRQIATNAGQEASVVANTVKNGTGNYGYNAGNDTYGDMLEMGILDPTKVTRSALQFAASIAGLMITTEAMIAEIPQESAPDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_PSESM
Sequence: MQIYKVGGAVRDRLLGQPVTDIDWVVVGASTEDMLVKGYRPVGTDFPVFLHPLTNEEYALARTERKSGVGYGGFVFHASPDVTLEQDLIRRDLTINAMAEDKDGNLTDPYNGQQDLEARVLRHVSPAFAEDPLRVLRVARFAARYAGHGFTVAPETLELMRQLSESGELKALTAERSWKEISRALMEDQPQVFIQVLHDCGALSELMPEVEALFGVPQPAAHHPEIDTGVHVLSVLEQSAIHKHPLTVRWACLLHDLGKGLTPESEWPRHIAHEHTGLRLIKAVNERFRVPRDCQELALLVGQYHTHGHRALELKPSTLLELLHSFDVYRRPQRFEEFIAACEMDARGRHGFEQRSYPQADYLRGAAHAARTVSVQPLLEKGLKGKELGDALKNERLKALKTYKAGHVA
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: GIMD1_BOVIN
Sequence: MNSNKMTINLALFGMTQSGKSSAGNIILGSTDFHSSFAPCSVTRDCSLGRSCHFRSFMRRGGQEVTLQVQVLDTPGYPHSRLSKKHVRQEVREALAHHFGQEGLHLALLVQRADVPLCGQEESSPVQMIQELLGHTWMNYTAILFTHAEKIEEAGFNEDEYLREASETLLKLLNSIQHRYIFQYKKGNSLSEQRLKILERIIEFVKENCYQVLTFK
What are the official names of this protein?
GTPase IMAP family member GIMD1, GIMAP family P-loop NTPase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
Protein: NUON_AZOPC
Sequence: MDFSNFLCIEQELKLIALLVILFLYDTFCSKEWKKYFQNIAIVGFAIVIISEFPPYFTMYGEAFGGIHISSQLTFFMKSILNVATFLVFLQANKWLSSEKMLLRQGEFYVIMLISLLGMYFMISAENFVMLYIGMETASLPLACLVAFDKYQEKSAEAAVKYILTSALSSGVMLFGLSFLYGSLGSFYYSDIALNIVSSPLVKLGFVFFFGGLGFKLSLVPFHLWTADVYEGAPTSVTAYLSVVSKGAATFALIFVLYKVFGRIELIWNNILCWLLLATIVLGNLFAIRQQNIKRFFAFSSISQAGYILLGIIAGTAQGMTSTIFYTLVYLFSNLAAFGVIASVEYQTNGDTRIVSFNGLYRSNPGLAFVMMLAVFSLGGIPPFAGFFSKFFIFMAAAEQKQYILVFIALLNTVMSLYYYLLIVKAMFIEKRGEVVLEKIGIDNYNRISMVICTIGIFVIGFLSAIYEYIETISFGVLQK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GGTA1_SAPAP
Sequence: MNVKGKVILSMLVVSTVIVVFWEYINSPEGSFLWIYHSKNPEVDDSAQKGWWFPDWFNNGIHNYQQEEEDIDKEKGREEEQRKEDDTTELQLWDWFNPKKRPEVVTVTKWKAPVVWEGTYNKAILENYYAKQKITVGLTVFAIGRYIEHYLEEFVTSANRYFMVGHKVIFYVMVDDVSKVPFIELGPLRSFKVFEVKPEKRWQDISMMRMKTIGEHILAHIQHEVDFLFCMDVDQVFQDHFGVETLGQSVAQLQAWWYKADPDDFTYERRRESAAYIPFGQGDFYYHAAVFGGTPIQVLNITQECFKGILLDKKNDIEAEWHDESHLNKYFLLNKPSKILSPEYCWDYHIGLPSDIKTVKLSWQTKEYNLVRNNV
What is the function of this protein?
Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid.  Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isogloboside 3 (iGb3) (By similarity).
What are the official names of this protein?
N-acetyllactosaminide alpha-1,3-galactosyltransferase, UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase, Galactosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 6 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Protein: PIMT_PYRAR
Sequence: MAKKLVDDLEREGVLKSERVKKALLSVPREEFVMPEYRMMAYEDRPLPLFADATISAPHMVAMMCELIEPRPGMSILEVGTGSGYHAAVCAEAIERRGKVYTVEIVKGLAIYAAQNLERLGYWGVVEVFHSDGKRGLEKFAPYDAIIVTAAAASIPSALVNQLKDGGIMVIPVEEGFGQVLYKVVRRGEKTEKKAVTYVLFVPLR
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_ECODH
Sequence: MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHVGQMLLTRADMEDRERFLNARDTLRALLDNNIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQKGLYTADPRSNPQAELIKDVYGIDDALRAIAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIAAGSKPGVIGDVMEGISVGTLFHAQATPLENRKRWIFGAPPAGEITVDEGATAAILERGSSLLPKGIKSVTGNFSRGEVIRICNLEGRDIAHGVSRYNSDALRRIAGHHSQEIDAILGYEYGPVAVHRDDMITR
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPO_MOUSE
Sequence: MAAPAASGLSRQVRSFSTSVVRPFAKLVRPPVQVYGIEGRYATALYSAASKEKKLDQVEKELLRVGQLLKDPKVSLAVLNPYIKRTVKVKSLNDITKREKFSPLTANLMNLLAENGRLGNTQGIISAFSTIMSVHRGEVPCTVTTASPLDDAVLSELKTVLKSFLSPNQILKLEIKTDPSIMGGMIVRIGEKYVDMSAKSKIQKLSKAMREML
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
What are the official names of this protein?
ATP synthase subunit O, mitochondrial, ATP synthase peripheral stalk subunit OSCP, Oligomycin sensitivity conferral protein, OSCP.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: QCRB_GEOTD
Sequence: MLNKLYDWVDERLDITPLWRDIADHEVPEHVNPAHHFSAFVYCFGGLTFFVTVIQILSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVIVMMFLHTLRVFFQGAYKKPREMNWIVGVLIFMVMMGLGFTGYLLPWDMKALFATKVGLQIAEAVPLIGPAIKTLLAGDPEIVGAQTLARFFAIHVFFLPAALLGLMAAHFLMIRRQGISGPL
What is the function of this protein?
Component of the menaquinol-cytochrome c reductase complex.
What are the official names of this protein?
Menaquinol-cytochrome c reductase cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MUTL_ECOSE
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGRNHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVCAQPLLIPLRLKVSAEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RBL3_ARATH
Sequence: MAVGDDDLENRMSAKDRGIGSRGGDRNRIGPPPLPVALSSSTEFGDNALSSRWTSWLVPMFVVANVAVFVVAMFVNNCPNHFESHRLRGHCVAKFLGRLSFEPLRTNPLFGPSSHTLEKLGALEWSKVVEKKEGWRLLTCIWLHAGVIHLGANMLSLVFIGIRLEQQFGFVRIGVIYLLSGIGGSVLSSLFIRNSISVGASGALFGLLGSMLSELFTNWTIYSNKIAALLTLLFVILINLAIGILPHVDNFAHVGGFVTGFLLGFILLARPQFKWLAREHMPQGTPLRYKYKTYQYLLWLLSLVLLIAGFVVALLMLFRGENGNDHCRWCHYLRCVPTSSWRCDDV
What is the function of this protein?
Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
RHOMBOID-like protein 3, AtRBL3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Note=Not localized in cytosol, mitochondria or chloroplast.
Protein: ISPH_STRMK
Sequence: MDVLLANPRGFCAGVDRAIEIVKRAIETLGAPIYVRHEVVHNRFVVDDLKQRGAIFVEELDEVPDNNTVIFSAHGVSQAVRQEAERRGLKVFDATCPLVTKVHFEVARHCRAGRDVVLIGHAGHPEVEGTMGQWNREAGTGQIYLVEDVEQVATLQINQPENFAYTTQTTLSVDDTRGIIDALRERFPAMQGPKNDDICYATQNRQDAVRDLAKRCDLVLVVGSPNSSNSNRLSELARREGVESYLIDGAHEIDPAWVAGKQHIGVTAGASAPQVLVDGVLARLAELGATGVGELDGEPESMVFALPKELRLRLVD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: HN_NDVM
Sequence: MDRTVNQVALENDEREAKNTWRLVFRIATLLLIVMTLAFSAAALAYSMEASTPGDLVGIPTAISRAEEKITSALGSNQDVVDRIYKQVALESPLALLNTESIIMNAITSLSYQINGAANNSGCGAPVHDPDYIGGIGKELIVDDASDVTSFYPSAFQEHLNFIPAPTTGSGCTRIPSFDMSATHYCYTHNVILSGCRDHSQSHQYLALGVLRTSATGRVFFSTLRSINLDDTQNRKSCSVSATPLGCDMLCSKVTETEEEDYNSVTPTSMVHGRLGFDGQYHEKDLDVTTLFGDWVANYPGVGGGSFIDSRVWFPIYGGLKPNSPSDTAQEGRYVIYKRYNDTCPDEQDYQIRMAKSSYKPRRFGGKRVQQAILSIKVSTSLGEDPVLTVPPNTVTLMGAEGRVLTVGTSHFLYQRGSSYFSPALLYPMTVNNKTATLHSPYTFNAFTRPGSVPCQASARCPNSCVTGVYTDPYPLVFHANHTLRGVFGTMLDDERARLNPVSAVFDNVSRSRITRVSSSSTKAAYTTSTCFKVVKTNKTYCLSIAEISNTLFGEFRIVPLLVEILKDDKV
What is the function of this protein?
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
What are the official names of this protein?
Hemagglutinin-neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein.
Protein: CAC1S_RABIT
Sequence: MEPSSPQDEGLRKKQPKKPLPEVLPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNVIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMDVEDLREGKLSLEEGGSDTESLYEIEGLNKIIQFIRHWRQWNRVFRWKCHDLVKSRVFYWLVILIVALNTLSIASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGLRQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSRGLPDKTEEEKSVMAKKLEQKPKGEGIPTTAKLKVDEFESNVNEVKDPYPSADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKVRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSTISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHYHQSEEMNHISDILNVAFTIIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTVQIQAGLRTIEEEAAPEIRRTISGDLTAEEELERAMVEAAMEERIFRRTGGLFGQVDTFLERTNSLPPVMANQRPLQFAEIEMEELESPVFLEDFPQDARTNPLARANTNNANANVAYGNSNHSNNQMFSSVHCEREFPGEAETPAAGRGALSHSHRALGPHSKPCAGKLNGQLVQPGMPINQAPPAPCQQPSTDPPERGQRRTSLTGSLQDEAPQRRSSEGSTPRRPAPATALLIQEALVRGGLDTLAADAGFVTATSQALADACQMEPEEVEVAATELLKARESVQGMASVPGSLSRRSSLGSLDQVQGSQETLIPPRP
What is the function of this protein?
Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle (PubMed:9465115, PubMed:15201141, PubMed:25548159, PubMed:27621462, PubMed:29078335, PubMed:29467163).  Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction (PubMed:9465115, PubMed:15201141, PubMed:27621462).  Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
What are the official names of this protein?
Voltage-dependent L-type calcium channel subunit alpha-1S, Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle, Dihydropyridine receptor alpha-1S subunit, DHPR, Voltage-gated calcium channel subunit alpha Cav1.1.
What is the protein family that this protein belongs to?
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma, T-tubule; Multi-pass membrane protein.