PharMolix/UniProtQA huggingface dataset:
Protein: OBP3_RABIT
Sequence: HSHSEVSQISGEWYSVLLASDHREKIEYNGSMRVFVEYIH
What is the function of this protein?
Binds the chemical odorant, 2-isobutyl-3-methoxypyrazine.
What are the official names of this protein?
Odorant-binding protein 3, Odorant-binding protein III, OBP-III.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
Protein: CORA_ECOLI
Sequence: MLSAFQLENNRLTRLEVEESQPLVNAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL
What is the function of this protein?
Mediates influx of magnesium ions.  Can also mediate cobalt and manganese uptake (PubMed:780341).  Alternates between open and closed states.  Activated by low cytoplasmic Mg(2+) levels.  Inactive when cytoplasmic Mg(2+) levels are high (By similarity).
What are the official names of this protein?
Magnesium transport protein CorA.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: METE_ALIFM
Sequence: MTTESKTKTVTHILGYPRVGAQRELKFAQEKYWRGEIEQKELLAVGSELRQRHWKDQSASGLDFVTAGDFAWYDHVLTTSLLLGHVPARHNNGFPDLDTLFKVGRGQSQNSCGCGEAASDMTKWFNTNYHYIVPEFSKNDKFNVSWSQLFDEIAEAQKQGHNVKPVLLGPLSYLWLGKEVNDEEVEQGFDRLSLLPRLLTAYQAIFSKLSALGVEWVQIDEPILALELPKAWADSFKLAYQVIQSDVKLLLTTYFDGVEHHLDKITKLAVNGLHIDVSAAPDQLDAIVSALPKEWVLSVGAVNGRNVWRADLERLHERLQPVKEALGDKLWIASSCSLLHSPVDLEQETELSKETLQWFAFAKQKLREVTLLADALDGNQNAILACHQYSQPLRERESAEHINKPAVQQRLAAITPALAERAEAYSVRAQHQAEKLGLPLLPTTTIGSFPQTSDIRQQRSAYRTGKLNEQDYVTAMKGHIADAVERQERLDLDVLVHGEAERNDMVEYFAENLNGFQATRFGWVQSYGSRCVKPAIVVADIEREAPITVSWTQYAQSLTTKQMKGMLTGPVTILGWTFPREDITRKEIAQQLALVLRDEVSDLQQAGINIIQIDEPAIREGLPIKKSDQKAYLDWAVEAFKISAASAKSETQIHTHMCYSEFNEIIESVAALDADVITIETSRSNMELLKAFEDFNYPNEIGPGVYDIHSPNIPSQEWIVDLIETAAARVPVERLWVNPDCGLKTRNWKETEAALENMVKAAKALRKKWQSNAA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: MUTYH_MOUSE
Sequence: MKKLQASVRSHKKQPANHKRRRTRALSSSQAKPSSLDGLAKQKREELLQASVSPYHLFSDVADVTAFRSNLLSWYDQEKRDLPWRNLAKEEANSDRRAYAVWVSEVMLQQTQVATVIDYYTRWMQKWPKLQDLASASLEEVNQLWSGLGYYSRGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFDQVTGVVDGNVLRVLCRVRAIGADPTSTLVSHHLWNLAQQLVDPARPGDFNQAAMELGATVCTPQRPLCSHCPVQSLCRAYQRVQRGQLSALPGRPDIEECALNTRQCQLCLTSSSPWDPSMGVANFPRKASRRPPREEYSATCVVEQPGAIGGPLVLLVQRPDSGLLAGLWEFPSVTLEPSEQHQHKALLQELQRWCGPLPAIRLQHLGEVIHIFSHIKLTYQVYSLALDQAPASTAPPGARWLTWEEFCNAAVSTAMKKVFRMYEDHRQGTRKGSKRSQVCPPSSRKKPSLGQQVLDTFFQRHIPTDKPNSTTQ
What is the function of this protein?
Involved in oxidative DNA damage repair.  Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone.  Possesses both adenine and 2-OH-A DNA glycosylase activities.
What are the official names of this protein?
Adenine DNA glycosylase, MutY homolog, mMYH.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: RL11_VEREI
Sequence: MAKKIVGFIKLQVPAGKANPSPPIGPALGQRGLNIMEFCKAFNAQTQGVEPGLPLPVVITAFADKSFTFIIKTPPATTLIKKAIKLEKGSASALSTKVGKITRAQLEEIAKTKMKDMNAANVDAAVRTLAGSARSMGVTVEGL
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: GAN_MOUSE
Sequence: MAEGSAVSDPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLASFKPRGYSECIVTIGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVLGGQDENKQTLSSGEKYDPDANTWTALPPMHEARHNFGIVEIDGMLYILGGEDGDRELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP
What is the function of this protein?
Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture.  May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Controls degradation of TBCB (By similarity).  Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
What are the official names of this protein?
Gigaxonin.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton.
Protein: RS2_CORK4
Sequence: MAVVTMRQLLDAGVHFGHQTRRWNPKMKRYIITERNGIYIIDLQQTLTYIDSAYEFVKETVAHGGNILFVGTKKQAQEAVATEAERVGMPYVNHRWLGGMLTNFQTVHKRLGRLKELQAMDAAENGYEGRTKKEVLMLTRERQKLERVLGGISDMNKVPSAIWIVDTNKEHIAVSEAQKLNIPVVAILDTNCDPDVVDYPIPGNDDAIRSAALLTGVIASAVEDGKKARAERAQAEAKAAAGDNDAPVSSEGESTEVASDAASTASETTATSSDESAAESSEAESK
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: MDCB_PSEU2
Sequence: MSALQWSPHPASLAERLADLAVDALIDEADLSPKPALVDRRGSGAHTDLHLGLMHSSALSLWPTFKWMADAATQFGVVGQPLREALGRLGREGEATMLRTTSGVNTHRGAIWALGLLVTAAALDAQECAPEAICARAGALARIKDRQVLTQNSHGDQVVRRYGVMGAREQAQQGFPAVRLFALPQLQRSRAAGSGEQNARLDALLAIMTTLDDTCVLHRAGIEGLNAMQQGAQRVLYAGGSVSLAGRRALNALDQHLLALNASPGGAADLLAACLFIDGLEPALGPVSRSA
What is the function of this protein?
Involved in the formation of 2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase.
What are the official names of this protein?
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: SRY_EUMJU
Sequence: MFGVLNSDDRRAAIQQPNILAFGRTSSDLWTSNPTSNYWCETRGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAVHREKYPDYKYRPRRKALPQKSDKLLPAASSSLLCRQVLVDKWYPFTYRDSCSRATHSHMEDQLSSSQPVNIANSLLQQEHHYSSTSLRGSPETLATHLSADPPFYPK
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: RPOA_SHEB5
Sequence: MQGSVTEFLKPRLVDIEQVNSTRAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSSKEGVQEDILEILLNLKGLAVTIEGKDEAMLTLSKSGAGPVIAADITHDGDVTIVNPDHIICHLTGNNDISMRIRVERGRGYVPASARAQTEDDDRPIGRLLVDASFSPVARIAYNVEAARVEQRTDLDKLVIDMTTNGTIDPEEAIRRSATILAEQLDAFVELRDVTEPELKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASLADDL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: MIAA_FRATH
Sequence: MSKLIYGLAGPTASGKTSLSILLAKKINAEIISVDSSLVYKGMDIGTAKPTLQEQDGIKHHLIDIIEPTGNFSVADFISSVNKLKKEIWARGREVLLVGGTMLYFKGLIEGLSALPESQAEIREALEYQKKAKGLQYLHQQLNEIDPQSAQKINPNDQQRIFRALEVIMISGKKYSELVKTSKVGGLDEDLKLCALVPNDRSILHKNIESRFRQMLDQGFLDEVQNLHKNPMLTKETTAIRSVGYRQAWEYLDGDISYDEFVKKGIVATRQLAKRQLTWIRNWQSSINIVAMENETKELDILKYFGYK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RS3_SALRD
Sequence: MGQKTHPIGFRLGAIRGWDSNWYSETNFQDKLVEDEELRRYLHTRLKRAGLSRAVIERTPERVILTLHTSRPGVVIGRGGSEVEKLKGELETLTGKDIQINISEIKRPELDATLVAKNIVQQLEGRISFRRAMKQAMQAAMRMGAEGVRIRAAGRLGGAEMGRTEEYMEGRVPLHTIRADIDFAQETALTIYGTIGVKVWIHRGEILGKPDLSPNVQAQQRKMKESPQQRRQRRGG
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PIT1_USTMA
Sequence: MERHDGEEYIPAIFGGQPPHASQVISLMKFSQETTTWNLPIMIAQALLVSEVIRTYPAELRMLHRLFQRKHPNMAEIFFILIKYLTIFAVIFDILVTETFAARTDFDCRSWAWTSSTFYFMCSTLVFCVIGWRARIIFRTSQVASWSLSVGLMGQFAVAMWTNYRVDKADALTPAGTCAPAAQVHADASQRNAALQLHFWQSSTFWFLLYNTIFESSILMACCIKLRKTSSGPSGLTKIAKVLFSNNVHYMAGVETCNVIELVMLLGWTSSLPPVHITSIAIQIVVGLQMLIGEQEAVYSPTCSQLSYSQYSSDSGGYINKHHAATSSSNGTFSTPSRTLSYVKRPGTGTTVADIGCADASGGGQHGRKGTFSSISSVPAYVKANPIVETVSPQMPSKAQSQSIPYKREVEVTVDMSPVPPPPGPSPAPLPAPYM
What is the function of this protein?
Plasma membrane virulence factor required for spreading and inducing tumors in infected leaves.
What are the official names of this protein?
Virulence factor PIT1, Proteins important for tumors 1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MTNN_BACC4
Sequence: MRIAVIGAMEEEVRILRDKLEQAETETVAGCEFTKGLLAGHEVILLKSGIGKVNAAMSTTILLEKYKPEKVINTGSAGGFHHSLNVGDVVISTEVRHHDVDVTAFNYEYGQVPGMPPGFKADEALVALAEKCMQAEENIQVVKGMIATGDSFMSDPNRVAAIRDKFENLYAVEMEAAAVAQVCHQYEIPFVIIRALSDIAGKESNVSFDQFLDQAALHSTNFIVKVLEELK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: TGT_SHESR
Sequence: MKFELDTTDGRARRGRLIFERGTVETPAFMPVGTYGTVKGMTPEEVRATGADILLGNTFHLWLRPGEEIMRKHGDLHDFMNWQRPILTDSGGFQVFSLGDIRKITEEGVHFRSPINGEKIFLDPEKSMQIQHALGSDVVMIFDECTPYPATEDEARKSMQMSLRWAKRSRDEFDRLENPNSLFGIIQGSVYEDLRDESLKGLVEIGFDGYAVGGLAVGEPKEDMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFTSEGVIKIRNARHRDDTSPLDPKCDCYTCKNYSRAYLYHLDRCNEILGARLNTIHNLRYYQMLMEGLRGAIETGTLDAFVKDFYTSQGREVPELVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RL10_JANMA
Sequence: MSLNLNDKKAVVAEISAKVASAQTIVVAEYRGIQVGHLTQLRAKARDQGVYLRVLKNTLARRAVEGTAFASLASEMTGPLIYSISDDAVAAAKVISDFSKTNDKLVVKAGNYAGKPLDKAAVTALANIPSREVLLAQVLGMMLVPVASFTRGLAALAAKKAEGAEPVAAAAPAAESTEAAAE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: HADI_CLODI
Sequence: MYTMGLDIGSTASKGVILKNGEDIVASETISSGTGTTGPSRVLEKLYGKTGLAREDIKKVVVTGYGRMNYSDADKQISELSCHARGVNFIIPETRTIIDIGGQDAKVLKLDNNGRLLNFLMNDKCAAGTGRFLDVMAKIIEVDVSELGSISMNSQNEVSISSTCTVFAESEVISHLSENAKIEDIVAGIHTSVAKRVSSLVKRIGVQRNVVMVGGVARNSGIVRAMAREINTEIIVPDIPQLTGALGAALYAFDEAKESQKEVKNI
What is the function of this protein?
Involved in the reductive branch of L-leucine fermentation.  Required for the activation of (R)-2-hydroxyisocaproyl-CoA dehydratase.  The reduced activator transfers one electron to the dehydratase concomitant with hydrolysis of ATP.  This protein is extremely sensitive towards oxygen.
What are the official names of this protein?
2-hydroxyisocaproyl-CoA dehydratase activator.
What is the protein family that this protein belongs to?
Belongs to the HadI activator family.
Protein: IDD2_ARATH
Sequence: MPVDLDNSSTVSGEASVSISSTGNQNPLPNSTGKKKRNLPGMPDPESEVIALSPKTLLATNRFVCEICNKGFQRDQNLQLHRRGHNLPWKLRQKSNKEVKKKVYVCPEVSCVHHDPSRALGDLTGIKKHFCRKHGEKKWKCDKCSKKYAVQSDWKAHSKICGTKEYKCDCGTLFSRRDSFITHRAFCDALAEENARSHHSQSKKQNPEILTRKNPVPNPVPAPVDTESAKIKSSSTLTIKQSESPKTPPEIVQEAPKPTSLNVVTSNGVFAGLFESSSASPSIYTTSSSSKSLFASSSSIEPISLGLSTSHGSSFLGSNRFHAQPAMSATALLQKAAQMGAASSGGSLLHGLGIVSSTSTSIDAIVPHGLGLGLPCGGESSSGLKELMMGNSSVFGPKQTTLDFLGLGRAVGNGNGPSNGLSTLVGGGTGIDMATTFGSGEFSGKDISRRKS
What is the function of this protein?
Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling.  GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins.
What are the official names of this protein?
Zinc finger protein GAI-ASSOCIATED FACTOR 1, Protein indeterminate-domain 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: AZOR_SHESR
Sequence: MSKVLVLKSSILGGYSQSALLVDHLIGKWEDQGATITVRDLAGKDVLPMVDGEIASGLRGGDDLTARQQEMLDLSNALVEELKANDTIVITAPMYNFNIPTQLKNWIDFVARAGVTFTYTENGPKGLVEGKRAVLITTRGGAHKDGPTDHIVPFLKTFLGFIGITDVEVVYGEALNMGPEANQKGISEAKQSLDALTV
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: DNAJ_BURP6
Sequence: MAKRDYYEVLGVAKNASDDEIKKAYRKLAMKYHPDRNPDSKDAEEHFKEAKEAYEMLSDGQKRAAYDQYGHAGVDPNVGAAGAQGFGGFADAFGDIFGDIFGQAAGGGRARGGPQVYRGADLRYSMEITLEQAAHGYDTQIRVPSWAACGVCHGSGAKPGTKPETCPTCHGQGTVRMSQGFFSIQQTCPKCHGTGTYIPEPCAHCHGSGKVKETKTLEVKIPAGIDDGMRIRSAGNGEPGINGGPSGDLYVEIHIKPHAVFERDGDDLHCQMPIPFTTAALGGEIEVPTLAGRASFTVPEGTQSGKTFRLRGKGIKGLRSSIAGDLYVHVQVETPVKLTDQQRDLLKQFEKSLAEGGPRHSPQSKSWFDRVKSFFE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSRP_XYLFM
Sequence: MSTIRPVFYVSDGTGITAETIGHSLLTQFSGFTFVTERMVFIDDAEKARDASQRILAASERYRVRPIVVNSCVNPYLSVILAESGALMLDVFAPFIGLLEHELNTSRHSRVGRAHGMVDFETYHRRINAMNFALAHDDGVAASYDEAEVVLVAVSRAGKTPTCIYLALHYGIRAANYPLIDEDLNSDQLPLRLRPYRKKLFGLTINPERLQQIRQERRPNSRYAALDTCKREVAAAERMFSAERITTLSTTHTSIEEISSKVLVTLGLQREMF
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: TIG_RUEST
Sequence: MQVTETLNEGLKRGYAITIPATELEEKVNAKLAEAQPEIEMKGFRKGKVPMPLLKKQFGARLMGEVMQEAVDGAMNKHFEESGDRPALQPDVKMTNEDWKEGDDVNVEMSYEALPAIPEVDVSGVELEKLVVKAEDAAVTEALENLASSAQEFEAREEGAASEDGDQVVIDFVGKVDGEAFDGGSAEDYPLTLGSNSFIPGFEEQLVGVKAGDAKDVTVTFPEEYGAEHLAGKEAVFSCTVKEVKAPKAAEINDELAKKFGAEDLDQLKGQISERLEAEYAGAARQVMKRAALDALAELVSFDLPPSLVEAEAKQIAHQLWHEENPDVQGHDHPEIEPTDEHNKLAERRVRLGLLLAEMGQKAEVEVTDQEMTQAIMQQARQYPGQERQFFEFIQQNAQMQQQLRAPIFEDKVIDLVFDQAKVSEKEVSKEDLQKAVEALEEE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: TSN3_PONAB
Sequence: MGQCGITSSKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASNCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGTYA
What is the function of this protein?
Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.
What are the official names of this protein?
Tetraspanin-3, Tspan-3.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
Protein: MINC_SHIFL
Sequence: MSNTPIELKGSSFTLSVVHLHEAEPKVIHQALKDKIAQAPTFLKHAPVVLNVSALEDPVNWSAMHKAVSATGLRVIGVSGCKDAQLKAEIEKMGLPILTEGKEKAPRPAPAPQAPAQNTMPVTKTRLIDTPVRSGQRIYAPQCDLIVTSHVSAGAELIADGNIHVYGMMRGRALAGASGDRETQIFCTNLMAELVSIAGEYWLSDQIPAEFYGKAARLQLVENALTVQPLN
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: GPA6_CAEEL
Sequence: MGAGATGLRGARLSPEERANSSKSRAIDRALSKDHTDDLNRFKILLLGTAESGKSTIFKQMRVLHLDGYAKEDALEYLSIIHSNCMEALTQLVDACTAFGINHDITVQEDVNRFEDFKRKLRDPEGLVIPVVIGRCMDRVWHSPSLQLCYDTRRFRFALLDSAKYFMDNIVRLTEDNYVPSIQDIVHCRISTTGINELAFNYKKMDFKMVDVGGQRSERRKWIHCFDNVDMILFIVSMSDYDQLDPEDNKYNRMKQSYEIFKTIVHSDLFRHASIVLFLNKYDVFVEKLKTSPLRRSFKNYEGDNSEESAREFIKKLFRRCITDRHKFFVFETTATDTGNIDLVFGSAVAHIVNENLRSAGLHE
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-6 subunit.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: SAM50_MOUSE
Sequence: MGTVHARSLEPLPSSGTDFGALGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIICEIGEVFKAKNLIEVMRRSHEAREKLLRLGIFRQVDVLIDTCHGEDALPNGLDVTFEVTELRRLTGSYNTMVGNNEGSMVLGLKLPNLLGRAEKVTFQFSYGTKETSYGLSFFKPQPGNFERNFSVNLYKVTGQFPWSSLRETDRGVSAEYSFPLWKTSHTVKWEGVWRELGCLSRTASFAVRKESGHSLKSSLSHAMVIDSRNSSILPRRGALFKVNQELAGYTGGDVSFIKEDFELQLNKPLALDSVFSTSLWGGMLVPIGDKPSSIADRFYLGGPTSVRGFSMHSIGPQSEGDYLGGEAYWAGGLHLYTPLPFRPGQGGFGELFRTHFFLNAGNLCNLNYGEGPKAHIRKLAECIRWSYGAGVVLRLGNIARLELNYCIPMGVQGGDRICDGVQFGAGIRFL
What is the function of this protein?
Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes.  Required for the assembly of TOMM40 into the TOM complex.
What are the official names of this protein?
Sorting and assembly machinery component 50 homolog.
What is the protein family that this protein belongs to?
Belongs to the SAM50/omp85 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm. Mitochondrion.
Protein: VAPC1_HAEIN
Sequence: MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLHYGKWANTLKKQGRPIGNNDLWFACHALSLNAVLITHNVKEFQRITDLQWQDWTK
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Acts as an RNase, its toxic effect is neutralized by VapB1 antitoxin (By similarity).
What are the official names of this protein?
Ribonuclease VapC1, RNase VapC1, Toxin VapC1.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.