PharMolix/UniProtQA huggingface dataset:
Protein: FLIW2_HELAH
Sequence: MNYFLKAPILGFEHISGVRLEKIDSLFSRLMGQTNSPMALDMVLVNPYCLREYSFVIPKYIELLLELDSHSKVEVYCVVVLQKNLEDSMVNFLAPLVFNSKNGFGAQVALSMMDYPDFGFRDPLKSFVIKERERA
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW 2.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTC24_HUMAN
Sequence: MSSPNPEDVPRRPEPEPSSSNKKKKKRKWLRQEASIQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRDTPVLQACAFNLGAAYVETGDPARGLELLLRAHPEEKAQGRRHGDQCFNVALAYHALGELPQALAWYHRALGHYQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAAALALGAAAGCMLKSGRHRVGEVVQVLEKSRRLAERSTERRLLGHLYNDLGLGYSQLQLFPLAVEAFLQALPLCWVPGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRERLVAKLADTVRTRLAQVGLVQTHTLTSAPGRLQAPGGASQAEGTPAKAGSSTAGVQHRSSSGWEDEEFEEGHQKKKEERSANVPVRAGPGRPELCFLPGTVNHSHHLASSCPTFTKHTPCRGTVLGKASIYSPGPRAHLPFVGPGPPRAEYPSILVPNGPQANRSSRWPRESLSRSRQRRPMESGICTIV
What are the official names of this protein?
Tetratricopeptide repeat protein 24, TPR repeat protein 24.
Protein: DLGD_HAEIG
Sequence: MRVSYDELKNEFKRVLLDRQLTEELAEECATAFADTTQAGAYSHGVNRFPRFIQQLEQGDIVPNAIPTKVLSLGSIEQWDAHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWMRGGSYGWQAAEKGYIGICWTNALAVMPPWGAKECRIGTNPLIIAVPTTPITMVDMSCSMYSYGMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKNRRLLPMGFWKGSGLSIVLDMIATLLSNGESTVAVTEDKNDEYCVSQVFIAIEVDRLIDGKSKDEKLNRIMDYVKTAERSDPTQSVRLPGHEFTTILSDNQANGIPVDERVWAKLKTL
What is the function of this protein?
Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
What are the official names of this protein?
2,3-diketo-L-gulonate reductase, 2,3-DKG reductase, 3-dehydro-L-gulonate 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSG_TOLAT
Sequence: MDYLPLFARLNNRAVLLVGGGDIALRKARLLLDAGANLTVVAPSLHEELTELLVGHTYIPSRFTAAYLNDQMLVIAATDDEEVNAEVAAAADAANIWVNVVDDPDRSSFIFPSIIDRSPIMVAVSSGGKAPVLVRMLRERLEALLPKHLGALANLSGEWRNQIKQKLGDITSRRRFWEKAFASPQLATLLETEQHDSAEQWMADQLQADDYAGGEIVLVGAGPGDAGLLTLKGLQQIQQAEVVLYDQLVSPEVLNLVRRDAERISVGKKAGHHSVPQHEINELLLSHARAGKRVVRLKGGDPFMFGRGAEELQAARAEGIPFSVVPGITAAAGATAYAGIPLTHRDSAQSAVFITGHCKQDGEEPDWAALAASNQTLVIYMGLIGSPAITERLIAHGRRPETPVALIERGTTVRQRVLRGTLQELPELAKDAHSPSLIVIGEVAALADTLSWFGGDTASGKEHLINLA
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: COPE_CAEEL
Sequence: MADKLFSIRNYFFLGSYQSCIGEALKFSSKNEEEKQEKDVYLYRSYIAQGQAFIPLKEIPAATKSADLAAVRRYAEFRNNPAAKKKILAEVQEEVASRNIKSEIAAVLAATILNEADLSQDAFRAVSRFEGLEARASKVFILIKMNKRKLAIGEVKKMNQIDEDATLSQLANALVTSFGASGKVKDALYIYSEMSDKYGRTTDLEMHQAVVSILTQDYAAAEELLESALERDNKDADVLINSIVSAQLNEKDDDVVERFISQLKHEHPNHPWVIDFNEKEAEFDRVASDSRA
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit epsilon, Epsilon-coat protein, Epsilon-COP.
What is the protein family that this protein belongs to?
Belongs to the COPE family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: PIMT_METMP
Sequence: MPLNEIIPVIENLISRGYIKKQSVIDAILSVPRHKFISKSMESYAYVDSPLEIGYGQTISAIHMVGIMCEELDLDEGQNVLEVGTGSGYHAAVVSKIVGESGKVTTIERIPELFENSKKTLSELGYNNVEVVLGDGTKGYLENAPYDRIYVTASGPDVPKALFKQLNDGGILLAPVGAHFQTLMRYTKINGSISEEKLLEVAFVPLIGENGF
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP228_ARATH
Sequence: MLLQFRAKTFFNNIAQDSLVTLITKRVGLGYRFLSSLCQPKNTALDSEGYKILFQTAAKSGSVVLGKLAHGHMIKSSLNPCLYLLNNLLNMYCKCRELGFARQLFDRMPERNIISFNSLISGYTQMGFYEQAMELFLEAREANLKLDKFTYAGALGFCGERCDLDLGELLHGLVVVNGLSQQVFLINVLIDMYSKCGKLDQAMSLFDRCDERDQVSWNSLISGYVRVGAAEEPLNLLAKMHRDGLNLTTYALGSVLKACCINLNEGFIEKGMAIHCYTAKLGMEFDIVVRTALLDMYAKNGSLKEAIKLFSLMPSKNVVTYNAMISGFLQMDEITDEASSEAFKLFMDMQRRGLEPSPSTFSVVLKACSAAKTLEYGRQIHALICKNNFQSDEFIGSALIELYALMGSTEDGMQCFASTSKQDIASWTSMIDCHVQNEQLESAFDLFRQLFSSHIRPEEYTVSLMMSACADFAALSSGEQIQGYAIKSGIDAFTSVKTSSISMYAKSGNMPLANQVFIEVQNPDVATYSAMISSLAQHGSANEALNIFESMKTHGIKPNQQAFLGVLIACCHGGLVTQGLKYFQCMKNDYRINPNEKHFTCLVDLLGRTGRLSDAENLILSSGFQDHPVTWRALLSSCRVYKDSVIGKRVAERLMELEPEASGSYVLLHNIYNDSGVNSSAEEVRELMRDRGVKKEPALSWIVIGNQTHSFAVADLSHPSSQMIYTMLETMDNVDFVDYTLVHFCSVT
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At3g13880.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
Protein: YCF12_EUGMY
Sequence: MNIELIVQLTSLILISIAGPIIIALLFVKQGNL
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PDXT_STAA1
Sequence: MKIGVLALQGAVREHIRHIELSGHEGIAVKKVEQLEEIEGLILPGGESTTLRRLMNLYGFKEALQNSTLPMFGTCAGLIVLAQDIVGEEGYLNKLNITVQRNSFGRQVDSFETELDIKGIATDIEGVFIRAPHIEKVGQGVDILCKVNEKIVAVQQGKYLGVSFHPELTDDYRVTDYFINHIVKKA
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: RSMA_LACP7
Sequence: MAYLGDPKQTIEVLNRYRFIFQKKFGQNFLIDTHVLEKIIRSAEITKDDLVLEIGPGIGTMTQYLCENAREVVAVEIDKNLIPILEQDTLSSYDNVTIINEDILKVDINQIVKEKNGGKPIKVVANLPYYITTPIIMGLFEAHVPIDNITVMVQKEVADRMQSGPGSKDYGALSLAVQYYADPYIVANVPPNCFMPRPNVGSAVIRLTLHQDAPVKVKNENLLFKLIRASFNQRRKTLANGLNNSPEISLPKEMISEAIEELGVVATIRGEALTLEQFAKLADIIDEKMK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARSC_BACCZ
Sequence: MENKKTIYFLCTGNSCRSQMAEAWGKQYLGDKWNVYSAGIEVHGVNPNAIKAMNEVNIDITNQTSDIIDANILNRADLVVTLCSHADSVCPSTPPDVNRVHWGFDDPAGKEWSEFQRVRDEIGERIKRFSETGE
What is the function of this protein?
Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].
What are the official names of this protein?
Arsenate reductase.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_DEIGD
Sequence: MRLMARTATNRTATVRRTTKETDITVTLDLDSPVSTPPTTGHGFLDHMLDALARHGRLGLSVRATGDLHIEPHHLIEDVGITLGQALNQALGGRRGIERYGSAFVPMDETLAHVVLDLSGRAHLAFEPERLDVWGDAGGMTHYHLREFLRGFCNHAGVTLHVRLLAGREAHHVIEAMVKAFARALRDAVRVTSEELASTKGLL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y038_CLOBJ
Sequence: MARGGFPNMGGANMNNLMKQAQKLQQDMEKMQGEMEKKEFSATVGGGAVTAVANGKKQIVDIKIEPEVVDEDDIEMLEDLIMSACNEALKKAEEDTSSEVKRLTGGMNLPGMF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein CLM_0038.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SYA_ACTP2
Sequence: MKTTSEIRQSFLDFFHSKGHTVVPSSSLVPENDPTLLFTNAGMNQFKDVFLGLEKRPYTRATTAQRCVRAGGKHNDLENVGYTARHHTFFEMMGNFSFGDYFKHDAIQFGWEYLTSPQWLGLPKEKLYVTVYETDDEAYDIWNKIVGVPTDHIIRIGDNKGAPYASDNFWAMGDTGPCGPCTEIFYDHGETFWGGLPGSPEEDGDRYIEVWNIVFMQFNRLADGTMEKLPKPSVDTGMGLERMTAVMQHVNSNYETDIFQTLIKEVAGLLNVSDLDNKSLRVVADHIRACSYLIADGVVPSNEGRGYVLRRIIRRAVRHGNLLGAKEAFFYKLVPTLATVMGHAGEVLTQKQAHIQKTLKAEEEQFARTLERGLALLEDALTKVENNTLSGEVAFKLYDTYGFPLDLTADVCRERELTIDEAGFEAEMTAQRERAKASSNFGTDYNNVIKVEGQTDFIGYDNLEAQATIVGLFSNGKAVDTIQSGESAVIILDQTSFYAEMGGQVGDSGLISTEICNFAVNDTQKYGQVFGHIGQLTSGSLSIGDKVTATVHATRRIAITANHSATHLLHSALREVLGDHVAQKGSLVSENILRFDFSQPEAISKSQLEEIERIVNRKIRENIQVTIETMDIESAKKKGAMALFGEKYGDVVRVVGMTEFSIELCGGTHVQRTGDIGLFKLVSEGAVAAGIRRVEAVTAETAIEWLHNQQKVLQQSAEFLKADSNSLVEKIQQLQDKAKRTEKELQQLKDKLAAQAGSELVKQANKINGVNVVVQKLENVEVKSLRTMVDDLKNQLESAIVVFGTVADEKVNLIVGVTKDLSSKVNAGELVGAMAQQVGGKGGGRADMAMAGGSEPQNLDNALKFAEEWIQAKL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMK_PSESM
Sequence: MKIAVLSRNPRLYSTRRLVEAGIERGHEMVVIDTLRAYMNIASHKPQIHYRGKPLEGFDAVIPRIGASVTFYGCAVLRQFEMMGVFPLNESVAIARSRDKLRSLQLLSRRGIGLPVTGFAHSPDDIPDLIQMVNGAPLVIKVLEGTQGIGVVLCETATAAESVIEAFMGLKQDIMVQEYIKEAGGADIRCFVVGDKVIASMKRQAKPGEFRSNLHRGGSASLIKITPEERMTALRAAKVMGLSVAGVDILRSNHGPLVMEVNSSPGLEGIEVTTSKDVAGMIIEYLEKNSGPHMTRTKGKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: GACII_DICDI
Sequence: MVRKLFNTSHKKELILDVDTTIVKIGTPKNVVLLTKWLDANGAIKEEGVFRVNGNTTTMEQIKKNFSQGKDDLTKYTSADIHSMAGCLKFILRELPEPIFTWDFYPIFIKIQCLQDESRKLFFLKMLIHGLPYTSRTLVFQLFGFLSKFSVHQDQNKMTPKNLATVFAPNVLRPKKEEDNFQLMNNQDSIGVIETLIEEFQYISNIQKNTLNSQEIKVKSVLPFDETTNAITQQSLVEDYLIAKANTPQESSSFKKNLPFKKGDIIKLLYIKNDGNFIGEINGITGNLSQTYVDIIDISELAEAFTLTPPPIPTLPIASTILHTPPTSSSSSSSSSSSSILLTDNQPKLCSSTPRINNSPSSFSPSLSSTTPQLLVQQSPRQSPRQIPSISLIVEPNNTNQPSFGHGTLQRTSTGYFSSKPLSISQPINMSKPTNMSPPTHHAMSMHNLPPSNTTRENHLPPLPTKPPPLTIPSSSSLPTTPIKQQPQQPIQQPLTPQNHHHHHHHNNLSSSVNTANTGNCANILSPNSDRYLSSRSQSSVHLSGSSSSSSSSSSSSSSSSSSSSSTSNRKFDFSLKSKSSKNSPSKNLPPQPTTTSTLTPPPPPTITTTTTTTTTTTTTTIATTPPPPSKPLPNIPVKDQQFNTLKRSTIEIPPPTITSTNINNNNNTINPRTLNYSFSSFSITYNNSQLGGQLSQEEPPGGVKSQSSYLDNNNLPSRNTNIPNLPPRPPPLNIPQQQQQYKPLPSPPQLQSPQSSLNQSLQIPLQQQQQVQQQKLTTHYILPPQNTNLSGKNLQRSSTSMLLNKLPPPPFSFNKN
What is the function of this protein?
Rho GTPase-activating protein involved in the signal transduction pathway.
What are the official names of this protein?
Rho GTPase-activating protein gacII, GTPase activating factor for raC protein II.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLUQ_BORPA
Sequence: MARRPVLARHRIDFRNRVNYIGRFAPSPSGPLHAGSLVAALASWLDARAHHGLWRLRIEDVDTPRTVPGAAGVIMDQLRALHLHWDGEIMWQSRRGAAYQQAFDALAARGLIYGCGCTRREIADSALRGTADVDGERPYPGTCREGLPASRQARAWRVRVPPGVETFVDRWLGPQQQDVAAAVGDFALRRADGLWAYQLAVVVDDADQGVTDVVRGADLLGSTARQRVLGRLLGLAPPRVMHVPLIVDPATGLKLSKQNGAPALDCSQPLRMLQQAWSGLGFAPLAAATPEAFLQAAAAQWAQRFGMRHAAVPASPKAD
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: CYSH_VIBA3
Sequence: MHNSVASKLKLAELLALTKTEQILRLGQINAELEQLTALERVKWALENLEGTHVVSSSFGIQAALMLHLVTQAKSDIPVILTDTGYLFPETYRFIDELSQKLTLNLQVFRAQQSSNWQEAQYGKLWDQGIEGIEKYNKLNKVEPMRRALDELEAGTWFSGLRREQSQSRANLPILSIQNGVFKFLPVIDWTNKDVHYYLEEHGLSYHPLREQGYLSVGDTHTTKKWEPGMTEEETRFNGLKRECGLHEDDGEQYGSGI
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRHL3_HUMAN
Sequence: MSNELDFRSVRLLKNDPVNLQKFSYTSEDEAWKTYLENPLTAATKAMMRVNGDDDSVAALSFLYDYYMGPKEKRILSSSTGGRNDQGKRYYHGMEYETDLTPLESPTHLMKFLTENVSGTPEYPDLLKKNNLMSLEGALPTPGKAAPLPAGPSKLEAGSVDSYLLPTTDMYDNGSLNSLFESIHGVPPTQRWQPDSTFKDDPQESMLFPDILKTSPEPPCPEDYPSLKSDFEYTLGSPKAIHIKSGESPMAYLNKGQFYPVTLRTPAGGKGLALSSNKVKSVVMVVFDNEKVPVEQLRFWKHWHSRQPTAKQRVIDVADCKENFNTVEHIEEVAYNALSFVWNVNEEAKVFIGVNCLSTDFSSQKGVKGVPLNLQIDTYDCGLGTERLVHRAVCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNSGVKGCLLSGFRGNETTYLRPETDLETPPVLFIPNVHFSSLQRSGGAAPSAGPSSSNRLPLKRTCSPFTEEFEPLPSKQAKEGDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGFPEENIYKVYKKCKRGETSLLHPRLSRHPPPDCLECSHPVTQVRNMGFGDGFWRQRDLDSNPSPTTVNSLHFTVNSE
What is the function of this protein?
Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity).  Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468).  xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity).  Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others.  Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury.  Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation.  Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity).  Also required for proper development of the oral periderm (PubMed:24360809).  No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).
What are the official names of this protein?
Grainyhead-like protein 3 homolog, Sister of mammalian grainyhead, Transcription factor CP2-like 4.
What is the protein family that this protein belongs to?
Belongs to the grh/CP2 family. Grainyhead subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: YCF78_CHLRE
Sequence: MITFTFMSLVTSVKDYVEITHKLIEIEPLKNYTEFGAVFTYFIFSIGEFFKNFFSFSFLNNIWSIPIIIPDIASAMISEVSVLDGYFHNAFTFLETSVNTTTNPSLVIFEKFVIGIINSLFLILPTSTSHLITLRRFVMQGLEAGYMAGLGTLAGNFLWLASIILGWRFFVIPWLSLDIFRYLLGFVLLVKYIWDSSKERRMALEDLSKWKIFLLNFLLALTEQSCIYPFISNLSFGPDASILEGFPVDNYPQFLLIHGAYLLGILFGSFSLLQFTCWFWENPAFSIYLWITTKSSLKISTSSYYKILNFTFLYATMLCAIASIPYYGLDYTITNPIGLVPQDRILNQKKSQSDPDKLITETAFLNLNPTDKNSRIRDGVHARRERWKQRLIKYQAFDASTYDQGVYDFLTIEDLNYGFDRFWLRRKMRNHQIRFRLFPGPWMRSLKKQLNNPANPSLETSTKAASGPRVEFFRILFEQFYHPNFHDRAAMQTNPAEARNKFISTSPLASTESKKALNSTFSLGNINNSSTGIEGLVLTNTQATLLPTDLQTKRTIKPGLIYTNSALRKFVRNVNTRLNLKLLNSKETNLTTKYKSQFIYSKRWKSIFSKIQPLQNGTTRKSYQLFRNVAKQILVTPDAKSLKLITINQKLSLKERKLLELRTQYNNNSTLTTTAPLTLVRPLNVYLQKEEAFKRKLRYYGTMPMRKLTVGNQAPYFKALMKRGFYYYKPTLRWRKTLYVASLRRGFRKKSRKQRILVMPSNQQNFNNTLDNTKTNINQNNLANPLGGNEVPMYGADGENSLITKPTHSYTVLGKRASRYRHQIYKDVLQHWYYTPFNRLLMKFDVDAFINRQPKSHFLTKNEERALHIRRFLLSEHYDTLRWYTYMQHYKTMKTNIGGTKSFANRAYNQQFQGTFKKIRHLFAITPKQGDFYTLKFDQPLYNDNKLKDNLYFHEELLTDYYNGTNLQTNQTSNISVNSTTTFIDNSLRTTQLPVPSSSFDIVNQSSTLIGLTTMQNALRKNVVESTLTSLNSDGEAATSQPKLNFVYSELFVKLIKECKKRIHDQTFLKNYITHRIEKREQLNQEQTKELNKRLEKLKVWLNSDKGSISKLQNTPVQDPNISSPDKVLTTAMQKAVNESISLSGIMPSDKIKTTYGNLTNAYTIKTENAILTKLNVINQLTNNETTTQKNTLIKSIGVNKIQTVLQTIITNFKSSLYNQTQLLRVKTDKDLQWWRTKQRVITKRKSARKRDRFKKQIAVVNKKLAALSKKVETEKSNLYQTLYGNYEISDYLLRNVPTGSSAVIDSTVLRKKQDNQAYLPKETNNVQFNSFVDSNNNVWQTFFAKKLRKKISSKGRRYRSLSLARYLTATRKPRLVGLDNLTKIDNITTLQGAFITKEEKQDSLNLTIQRKQELTNSLKKSQIKKRSRHSWKKRSRHQFSRNHYKYRKRHTHGNGKLRVMNKKLKKFKATNELRQWWWNSFLPRYLSNLQVNNSTLTNKNVSFKPLSNTNSVPSTNMASPTTSRNLLDNLNSSNQISTSASMNQNIVTESVKVETNQVYLPEGEKSFDITSMTTTLPFYAGWDESLKKFVVTNRLLSRRDAGLSVNNNPQEINFTNPPIQGLNEGSFLYWQTEMPFNSYNIDQFITTNQSFYAPLGWRRFEFRHSILKTWVNNTKAGNNNIKKKTLIISLKNLQPLKSSQQKQNQIKTKKLVARRIKKRYKLLKQMPNQLMYSPTGPLLTEVLPSHYISVFDQQYRLPRNRYLKRNPLKTLKKTTLLALMDSSKQTNGVNKEFTLRKRVKPRRKYHRKRFIKKDGLIFPRRTKFNTNTTLTGNALITNNVNSIEEDDLRWRPSSRTKQKRKDNTRSSAASKTKSNKRVKTNPLRLRQLRRREFQQVLKPLQRYIPQNGGFTWPGDYLRLEIVEMPKLKSINIKKTSLKQKINVQPVGIMPRKYLIEKHNIKVLKKKLSQAYSTQQLTKVVQEYKNLIQNSPPAI
What is the function of this protein?
Essential for cell growth.  May be involved in binding chloroplast DNA to either the chloroplast envelope or the thylakoid membrane.
What are the official names of this protein?
Uncharacterized membrane protein ycf78, ORF-S, ORF1995, ORFA.
What is the protein family that this protein belongs to?
Belongs to the ycf78 family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: NICK_NOSS1
Sequence: MVSTLDDTKRNAIAEKLADAKLLQELIIENQERFLRESTDNEISNRIRDFLEDDRKNLGIIETVIVQYGIQKEPRQTVREMVDQVRQLMQGSQLNFFEKVAQHELLKHKQVMSGLLVHKAAQKVGADVLAAIGPLNTVNFENRAHQEQLKGILEILGVRELTGQDADQGIWGRVQDAIAAFSGAVGSAVTQGSDKQDMNIQDVIRMDHNKVNILFTELQQSNDPQKIQEYFGQIYKDLTAHAEAEEEVLYPRVRSFYGEGDTQELYDEQSEMKRLLEQIKAISPSAPEFKDRVRQLADIVMDHVRQEESTLFAAIRNNLSSEQTEQWATEFKAAKSKIQQRLGGQATGAGV
What is the function of this protein?
Acts as a DNA nickase.
What are the official names of this protein?
DNA nickase, Alr3199 protein.
What is the protein family that this protein belongs to?
Belongs to the hemerythrin family.
Protein: PLT1_ARATH
Sequence: MNSSGVEQGVVIAESEPPRGNRSRYAFACAILASMTSIILGYDIGVMSGASIFIKDDLKLSDVQLEILMGILNIYSLVGSGAAGRTSDWLGRRYTIVLAGAFFFCGALLMGFATNYPFIMVGRFVAGIGVGYAMMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYFFSKLPEHLGWRFMLGVGAVPSVFLAIGVLAMPESPRWLVLQGRLGDAFKVLDKTSNTKEEAISRLDDIKRAVGIPDDMTDDVIVVPNKKSAGKGVWKDLLVRPTPSVRHILIACLGIHFAQQASGIDAVVLYSPTIFSKAGLKSKNDQLLATVAVGVVKTLFIVVGTCVVDRFGRRALLLTSMGGMFLSLTALGTSLTVINRNPGQTLKWAIGLAVTTVMTFVATFSIGAGPVTWVYCSEIFPVRLRAQGASLGVMLNRLMSGIIGMTFLSLSKGLTIGGAFLLFAGVAAAAWVFFFTFLPETRGIPLEEMETLFGSYTANKKNNSMSKDNEVVDGQ
What is the function of this protein?
Plasma membrane sugar-proton symporter.
What are the official names of this protein?
Putative polyol transporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SRTA_BACAN
Sequence: MNKQRIYSIVAILLFVVGGVLIGKPFYDGYQAEKKQTENVQAVQKMDYEKHETEFVDASKIDQPDLAEVANASLDKKQVIGRISIPSVSLELPVLKSSTEKNLLSGAATVKENQVMGKGNYALAGHNMSKKGVLFSDIASLKKGDKIYLYDNENEYEYAVTGVSEVTPDKWEVVEDHGKDEITLITCVSVKDNSKRYVVAGDLVGTKAKK
What is the function of this protein?
Transpeptidase that anchors surface proteins to the cell wall (PubMed:15968076).  Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal.  Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (PubMed:15968076).  This sortase recognizes a Leu-Pro-x-Thr-Gly (LPXTG) motif, which is cleaved by the sortase between the threonine and glycine residues (PubMed:15968076).  Important for growth in macrophages.  May be critical in the early stages of inhalation anthrax (PubMed:16041044).
What are the official names of this protein?
Sortase A.
What is the protein family that this protein belongs to?
Belongs to the bacterial sortase family. Class A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: P2R3D_MOUSE
Sequence: MPERPPIRALRRDPDDPAVAQALASLARGSDLVFPSRFQKWLRDFRQVHAHRKEEPPPQSPPPGHTVPAFYFPCGRPPPRPQDTEDAIALVECAFEGLPRGRAGLGDMAVVAKACGCPLYWKAPLFYAAGGERTGSVSVHMFVAMWRKVLLTCHDDAARFVRLLGHPGCSGLIQEDFVPFLQDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQLEVEPDINRMTSFFSYEHFYVIYCKFWELDLDRDLTIDRSDLARHGDGAISSRMIDRIFSGAVTRARLPRKVGKLSYADFVWFLLSEEDKTTPTSTEYWFRCMDLDGDGALSMFELEFFYEEQAQRMAARGVEPLPFHDLARQVLDLVAPRCPGRITLRDLKQCGLAGEFFDAFFNVDKYLAREQREQAGTPQDTDSDPAASAWDRYAAEEYDFLVAEEAMAEDDDDHDEGSDPIDLYGLADEDCDDLEPL
What is the function of this protein?
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.  Interacts with retinoblastoma-related protein p107 (in vivo).  May target PP2A core dimer to p107 resulting in dephosphorylation of p107.
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta, PP2A B''-PR59, PP2A PR59, Protein phosphatase 2A, 59 kDa regulatory subunit B, Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha.