PharMolix/UniProtQA huggingface dataset:
Protein: CITG_ECOSE
Sequence: MSMPATSTKTTKLATSLIDEYALLGWRAMLTEVNLSPKPGLVDRINCGAHKDMALEDFHRSALAIQGWLPRFIEFGACSAEMAPEAVLHGLRPIGMACEGDMFRATAGVNTHKGSIFSLGLLCAAIGRLLQLNQPVTPTTVCSTAASFCRGLTDRELRTNNSQLTAGQRLYQQLGLTGARGEAEAGYPLVINHALPHYLTLLDQGLDPELALLDTLLLLMAINGDTNVASRGGEGGLRWLQREAQTLLQKGGIRTPADLDYLRQFDRECIERNLSPGGSADLLILTWFLAQI
What is the function of this protein?
Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.
What are the official names of this protein?
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: Y012_SIFVH
Sequence: MPAFGECQKIINPQGLPLEALSQSERIFLEFCELYDSYPEEIKEAIKQW
What are the official names of this protein?
Uncharacterized protein 12.
Protein: SYY_SALCH
Sequence: MASSNLIKQLQERGLVAQVTDEDALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVAKIRKQVAPFLDFDCGENSAIAANNYDWFGSMNVLTFLRDIGKHFSVNQMINKEAVKQRLNRDDQGISFTEFSYNLLQGYDFACLNKLHGVALQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMDIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLVAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDAELQPSRGQARKTIASNAVTINGEKQSDPEYIFNDEDRLFGRYTLLRRGKKNYCLICWK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P10_ASFWA
Sequence: MPTKAGTKSTANKKTTKGSSKSGSARGHTGKTHAPPSMHSGMLYKDMVNIARSKGIPIYQNGTRLTKSELEKKIKRSK
What is the function of this protein?
May play a role in genome packaging through direct interaction with viral DNA.  Binds to ssDNA and dsDNA with the same apparent affinity in vitro.
What are the official names of this protein?
Structural DNA-binding protein p10, p10.
What is the protein family that this protein belongs to?
Belongs to the asfivirus P10 family.
What are the subcellular locations of this protein?
Virion. Note=Found in association with the viral nucleoid.
Protein: RPOC2_DRANE
Sequence: MAERANLVFHNKVIDGTAIKRLISRLIDHFGMAYTSHILDQVKTLGFQQATATSISLGIDDLLTIPSKGWLVQDAEQQSLILEKHHHYGNVHAVEKLRQSIEIWYATSEYLRQEMNPNFRMTDPFNPVHMMSFSGARGNASQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVVRRTDCGTIRGISVSPRNKNRMMSERIFIQTLIGRVLADDIYIGSRCVAFRNQDLGIGLVNRFITFGTQSISIRTPFTCRSTSWICRLCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEHVRAPYNGKIKFNEDLVHPTRTRHGHPAFLCYIDLSVIIESDDIIHNVTIPPKSFLLVQNDQYVESEQVIAEIREGASTFHFKERVRKYIYSGSEGEMHWSTDVSHAPEFTYSNVHLLPKTSHLWILSGGSCGSSLIRFSIHKDQDQMNIPFLSAQIKSISSLSVNNDQVSQKFCSSDFYDKKKSGITDYSELNGIVGTSHYNFIYSTIFHENSDLLAKRRRNRFLIPFQSIQEQEKEFIRHSGISIEIPINGIFRRNSIFAFFDDPRYRRKSSGILKYGTLRADSIIQKEDMIEYRGGQKFKTKYEMKVDRFFFIPEEVHILPESSVIMVQNYSIIGVNTRITLNIRSQVGGLIRVERKKKRIELKIFSGDIHFPDKTDKISRHSGILIPPGRGKTNPKESKKLKNWIYVQRITPTKKKFFVLVRPVGTYEIANSINLATLFPQDLFREKDNIELRVFNYILYGNGKPTRGISDTSIQLVRTCLVLNWDQDTKNSSLEEVRAFFIEVSTKGLIRDFIRIGLVKSHISYIRKRNNPPDSGLISADHINPFYSISPKAFILQQSLRQNHGTVRMFLNSNKESPSLLILSSSNCFRIGLFNHVKYHNVINQSIKKNPLITIKNSSGPLGTAIQISNCYSFLPLLTYNKISAIKYLQLDKVKYSFQVINSYLIDENGRSFNLDRYSNGVLNPLKLNWYFLHQNYYHNYCEETSTIISLGQFFCENLCIAKKEPHLKSGQVLIVQKDSIVIRSAKPYLATPGAKVHGHYREILYEGDTLVTFIYEKSRSGDITQGLPKVEQVLEVRSIDSISLNLEKRIKGWNKCITRILGIPWGFLIGAELTIVQSRISLVNKIQKVYRSQGVQIHNRHIEIIVRQITSKVLVSEEGMSNVFLPGELIGLLRAERTGRALEEAICYRAILLGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVLGGMIPAGTGFNKGLVHCSRQHTNTLLEKRTKNLSLFEGDMKDILFYHREFFDSSISISKSSFSRI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: N4BP3_RAT
Sequence: MATASGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDGLLRKGLGQREFFSYLHLPKKDGKTAKRAPRNEPDYTTLYYREHPRAGDFSKTSLPERGRFDKCRIRPSVFKPPVSTGKGFLSMQSLAAHKGQKLWRSNGSLHTLACHPPLSPGPRASQARAQLLHALSLDEGGPEPSLSDSSSGGSFGRSPGTGPSPFSSSLGHINHLGGSLDRASRSPKESGPLAVLSCLPEPPPPYEFSCPTTEEVAVLPDTCEELKRDLGDQDVSNPFTQVLEERQRLWLSELKRLYVDRLHEVAQKAERSERNLQLQLFMAQQEQRRLRKELRAQQGLAPEPRTSGPPMEADPNARPEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELARLREAVRSLQEQAPREEAPGSCETDDCKSRGLLGEAGGNEAREGAEQLRAELLQERLRGQEQALRFEQERQTWQEEKERVLRYQREIQGSYMDMYRRNQALEQELRVLREPPTSWSPRLESSKI
What is the function of this protein?
Plays a positive role in the antiviral innate immune signaling pathway.  Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (By similarity).  Also plays a role in axon and dendrite arborization during cranial nerve development (PubMed:24044555).  May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (PubMed:24044555).
What are the official names of this protein?
Nedd4 binding protein 3, N4BP3.
What is the protein family that this protein belongs to?
Belongs to the N4BP3 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle. Cell projection, axon. Cell projection, dendrite. Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites.
Protein: GCSH_IDILO
Sequence: MSNIPADLKYASTHEWVRDEGDGTFTVGISEHAQELLGDMVFVELPDVGDKVATGDDIAVAESVKAASDIYAPMTGEVVAINEDLEDAPETVNNDPYGDGWLFRIKADDSSELDNLLDANTYEASIDED
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RLMH_FRATF
Sequence: MMAFLLDIITFLQISFSTNIFRINYKWVSDGYDEYKKRLSKLIPLELIELPIAKRTKTGNPKLWMEQEAKTILGKLNDSDHLVILDVNSKIISTEELADKMQNWKFNNPNVVILIGGPDGIDQSIKDIAKEKISISKMTFPHPLVRIIAEQLYRAYTILEGHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_RHORT
Sequence: MSVRTYRDISRRVSRKIRVGSVFVGGDAPVSVQTMTNTLTTDVAATVAQIRRAQEAGADIVRVSCPDEESTAALKAIISQVEVPIVADIHFHYKRAIEAAEAGAACLRINPGNIGSAERVREVVRAAKDHGCSMRIGVNAGSLEKELLEKYGEPCPEAMVESALSHARILEDNDFTEFKISVKASDAFLAVAAYKALAEACDYPLHLGITEAGGLRGGTVKSAIGIGSMLWAGIGDTIRVSLSAQPEEEVKVGFEILKSLNLRHRGVRVVSCPSCARQGFDVIKTVEVLESRLSHIQTPITLSIIGCVVNGPGEARETDIGLTGGGNLAKEGALNKVYVSGIPDHTINNEAMVDHLVALVEKKAAEIEALEAARKAKEPATAAE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: KTHY_XANOP
Sequence: MTIELKPGGLLIAIEGIDGAGKTTLARRLTTTLEAAGARVVLSKEPTNGPWGTKLRQSAATGRLSADEEAELLIRDRHEHVDTLIAPALARGDIVILDRYFPSMVAYQGAAGLPLDELLELNAFAPRPDVLLLLDLPPPTGLARIRARGDAPNHFETQDNLERCRTIFAGLELPGKHVVDASADADSVLRQAHAIIVAALADRLSGDGAPADTGKAALELLSAGRPA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: JZT49_CHIGU
Sequence: MKTLVLFIIFGLAALFLLSSANELEETERGCGLLMDACDGKSTFCCSGYNCSPTWKWCVLDCPNLFLLPPTKTLC
What is the function of this protein?
Probable ion channel inhibitor.
What are the official names of this protein?
U9-theraphotoxin-Cg1a, U9-TRTX-Cg1a, Jingzhaotoxin-49, JZTX-49, Peptide F2-41.53.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 43 (Jztx-49) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBN_ORYSI
Sequence: METATLVAISISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SYM_LACLA
Sequence: MTENKTFYITTPIYYPSGKLHLGSSYTTIACDVLARYKRLMGFDTFYLTGLDEHGMKIQRKAEELGMTPKEYLDPMAADVQELWKKLDISYDKFIRTTDTYHEEAVAKAFEQLLEQDDIYLGKYAGWYSVSDEEFFTETQLEEIFRDESGNITGGIAPSGHEVEWVEEETYFFRMGKYADWLLQYYDEHPDFIQPEVRKNEMVNNFIKPGLEDLALTRTSFTWGIPVPSNPKHVVYVWFDALLNYITALGYNSDNDSNFKKYWPGINMVGKEIVRFHTIYWPIMLHALGLPAPKKIFAHGWLLMKDGKMSKSKGNVVYPEMLIERYGLDAVRYYLMRAISFGQDGIFTPEDFVGRINFDLANDLGNLLNRTVSMINKYNDGKIEATGVSTEFDASLEEVVEETISHFHKAMDKFEFNVALADVWTLISRTNKYIDETAPWVLAKSEDDKAKLNNVLYHLAENLRIAGALLQPFMRATSGKIFEQLGMDERSFSLENLSFGYSFTHPVVAKGQPIFPRLDVEEEVAYIKLQMAGGVLPEKEWVPEEVELNLTLPQIKFDDFEKIELKVAEVLEVEPVEGSDKLLRFKLDAGDSEPRQILSGIAQFYPNEQELVGKKLQIVANLKPRKMMKKYVSQGMILSAEFDGKLSVLTVDDDVPAGSLIG
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_TRIV2
Sequence: MVSSITRIQNYVIDGAATSDGLATVLESNFAPSLISLPATPLFGTDGIRGKVGELLSAPLALQIGFWAGVVLRSHAGQLRPVILGQDSRNSSDMLAMALSAGLTAAGLEVWYLGLCPTPCVAYLTSVSEAIGGVMISASHNPPEDNGIKIFGANGGKLSQALQAEIEKGLRGNLPITSNVSNCGRHYSRRELVKDYGEALKRPWQNKVNLQGMKVVLDLAWGAAVGLAPSVFAEMGAEVISLHNAADGDRINVNCGSTHLEMLQAAVQEHNADLGFAFDGDADRVLAVDPTGRPVNGDYILYLWGLHLKQQNQLPDNLIVSTVMANLGFEKAWQQQGGKLIRTAVGDQYVQAEMIKTGAMLGGEQSGHILCSHYGMTGDGLLTALHLASLVKQSGVSLAELIDQSFQTYPQLLRNVRVVDRDRRLNWQNCTPVQQAIALAEKAMGDTGRILVRASGTEPVIRVMVEAANAELANYWTNELVAQVQQHLAP
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: URE1_YERPP
Sequence: MPQISRQEYAGLFGPTTGDKIRLGDTNLFIEIEKDLRGYGEESVYGGGKSLRDGMGANNNLTRDNGVLDLVITNVTIVDARLGVIKADVGIRDGKIAGIGKSGNPGVMDGVTQGMVVGVSTDAISGEHLILTAAGIDSHIHLISPQQAYHALSNGVATFFGGGIGPTDGTNGTTVTPGPWNIRQMLRSIEGLPVNVGILGKGNSYGRGPLLEQAIAGVVGYKVHEDWGATANALRHALRMADEVDIQVSVHTDSLNECGYVEDTIDAFEGRTIHTFHTEGAGGGHAPDIIRVASQTNVLPSSTNPTLPYGVNSQAELFDMIMVCHNLNPNVPADVSFAESRVRPETIAAENVLHDMGVISMFSSDSQAMGRVGENWLRILQTADAMKAARGKLPEDAAGNDNFRVLRYVAKITINPAITQGVSHVIGSVEVGKMADLVLWDPRFFGAKPKMVIKGGMINWAAMGDPNASLPTPQPVFYRPMFGAMGKTLQDTCVTFVSQAALDDGVKEKAGLDRQVIAVKNCRTISKRDLVRNDQTPNIEVDPETFAVKVDGVHATCEPIATASMNQRYFFG
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1897_STRPS
Sequence: MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKKGDPDPESNSALKFVIDRAKQAQVPKHIIDKAIDKAKGNTDETFTEGRYEGFGPNGSMLIVDTLTSNVNRTAANVRAAFGKNGGNMGASGSVSYLFDNKGVIVFGGEDADAVFEQLLEADVDVDDVEAQEGTITVYTAPTDLHKAIVALRESGIEEFQVTELEMIPQSEVELSGEDLETFEKLYSVLEDDEDVQKIYTNVDGF
What are the official names of this protein?
Probable transcriptional regulatory protein SPCG_1897.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family. YeeN subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_SYNS9
Sequence: MDTHAFKRSLHHSERYNRRGFGRAEEVAENLEQAYQSGLIGTIRDNGYKLTHGRLNVHLAEAFGFCWGVERAVAMAYETRRHYPSERLWITNEIIHNPSVNDHLREMDVLFIPVEEGVKDFSGVTSGDVVILPAFGATVQEMQLLNERGCHIVDTTCPWVSKVWNTVEKHKKHTFTSVIHGKVKHEETLATSSFAGTYLVVLDLEEAQIVVDYILGKGDREAFMQRFAKACSEGFDPDRDLERLGVANQTTMLKSETEEIGRMFERTMLSKYGPADLNEHFLAYNTICDATQERQDAMFSLVDEPLDLLVVIGGFNSSNTTHLQEIAVSRGIRSFHIDTPDRIDETTNSIEHKPLSEDLKRDQVFLPAGPVTVGITSGASTPDRAVEAVIEKLMRLSEN
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: PLAC1_RAT
Sequence: MKLIKFLGGVVFFTLMFSGYSEQNQVNVLCSTDWFMVTVHPFLLNNDVFVHFYEVHLGLGCPPNHIHPHFYQFNYRVTECGIRIKAVSPDVVIYSSEIHYASKGSSARYVIPVSCAAPRRSPWLTKPYSAKAPSSNMGATPKNDTSYHVFTLPEPSQQPNCSCPPYVFNQKSM
What is the function of this protein?
May play a role in placental development.
What are the official names of this protein?
Placenta-specific protein 1.
What is the protein family that this protein belongs to?
Belongs to the PLAC1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SCG3_RAT
Sequence: MGFLWTGSWILVLVLNSGPIQAFPKPEGSQDKSLHNRELSAERPLNEQIAEAEADKIKKTYPSESKPSESNFSSVDNLNLLKAITEKETVEKAKQSIRSSPFDNRLNVDDADSTKNRKLTDEYDSTKSGLDRKVQDDPDGLHQLDGTPLTAEDIVHKIATRIYEENDRGVFDKIVSKLLNLGLITESQAHTLEDEVAEALQKLISKEANNYEEAPEKPTSRTENQDGKIPEKVTPVAATQDGFTNRENDDTVSNTLTLSNGLERRTNPHRDDDFEELQYFPNFYALLTSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDETIALQTKNKLEKNTTDSKSKLFPAPPEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNLGGKTDEAKGKTEAYLEAIRKNIEWLKKHNKKGNKEDYDLSKMRDFINQQADAYVEKGILDKEEANAIKRIYSSL
What is the function of this protein?
Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:12388744, PubMed:14597614).  Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (PubMed:12388744, PubMed:14597614).  May also play a role in angiogenesis.  Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity).
What are the official names of this protein?
Secretogranin-3, 1B1075, Secretogranin III, SgIII.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts.
Protein: PACRG_MOUSE
Sequence: MPKRTKLLPQQTFQVHQPRSLVSEGFTVKAMMKNSVVRGPPVAGAFKERPAKPTTFRKCYERGDFPIALEHDSKGNKIAWKVEIEKLDYHHYLPLFFDGLSEMTFPYEFFARRGIHDMLEHGGNKILPVIPQLIIPIKNALNLRNRQIICVTLKVLQHLVVSSEMVGEALLPYYRQILPILNIFKNMNVNSGDGIDYSQQKRENIGDLIQETLEAFERYGGEDAFINIKYMVPTYESCLLN
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).  Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin).  Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited.  May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (By similarity).
What are the official names of this protein?
Parkin coregulated gene protein homolog, Hypertension-related protein 1-like protein, PARK2 coregulated gene protein.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: GLUQ_DEIGD
Sequence: MNVLPVVGRFAPSPTGAMHLGNARTALLAWLHSRALGGLHLLRFEDLDTGRVRSWAYDTTRRDLEWLGLDWDAEFRQSERLPVYADAVSRLTAAGETYPCTCTRREIRQAIEDSAGAPHGHEPVYPGTCRLHGAMPGRPAALRWHVPDGTVCVTDALTCATLCQNLPAEVGDFVLRRNDGVYAYHLAVVVDDALMGVTDVVRGADLWTATPRQVALGRALGSAPPRYLHVPLMTDFRGERLAKRGGAPPLRALREGGEEAGRVLSALARSLGWAVPERVSAAELLPLWRAQLTRAGFFINPQS
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: ECR_HELVI
Sequence: MSLGARGYRRCDTLADMRRRWYNNGPFQTLRMLEESSSEVTSSSALGLPPAMVMSPESLASPEIGGLELWGYDDGITYSMAQSLGTCTMEQQQPQPQQQPQQTQPLPSMPLPMPPTTPKSENESMSSGREELSPASSVNGCSTDGEARRQKKGPAPRQQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYICKFGHACEMDIYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRKEKKAQREKDKLPVSTTTVDDHMPPIMQCDPPPPEAARILECVQHEVVPRFLNEKLMEQNRLKNVPPLTANQKSLIARLVWYQEGYEQPSEEDLKRVTQSDEDDEDSDMPFRQITEMTILTVQLIVEFAKGLPGFAKISQSDQITLLKACSSEVMMLRVARRYDAATDSVLFANNQAYTRDNYRKAGMAYVIEDLLHFCRCMYSMMMDNVHYALLTAIVIFSDRPGLEQPLLVEEIQRYYLNTLRVYILNQNSASPRGAVIFGEILGILTEIRTLGMQNSNMCISLKLKNRKLPPFLEEIWDVADVATTATPVAAEAPAPLAPAPPARPPATV
What is the function of this protein?
Receptor for ecdysone.  Binds to ecdysone response elements (ECRES) (By similarity).
What are the official names of this protein?
Ecdysone receptor, 20-hydroxy-ecdysone receptor, 20E receptor, EcRH, Ecdysteroid receptor, HvEcR, Nuclear receptor subfamily 1 group H member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: WIPI1_XENLA
Sequence: METGGGGDGTGDICCLSYNQDCTSVAIGMRSGYKLYSLSNVERLDLVHESCEAKDVYIVERLFSSSLVVVVSHAKPRQMNVLHFKKGTEICNYNYSDNILSIRLNRQRLIVCLEESIYIHNIKDMKLLKTLLDTPRNPHGLCTLSINHSNSYLAYPGSSSTGEVSLYDANCLKCECTIPAHDSPLAAIAFNSTGTKLASASEKGTVIRVFSIPDGQKLYEFRRGMKRYVNISSLVFSMDSQFLCASSNTETVHVFKLEQLPERSEENASWTGYMGKMFMAASNYLPTQVSDMMNQDRAFATVRLNFSGQKNACTLVTIQKLPRLLVTSSSGHLYVYNLDPQDGGECVLIKKHSLLGSAKSETDGDSDAESPVPVSYAATVARPSSAPALSTITGYSEDGGTLRGEVIPEHELAVGPVCLDDEKEFPPVSIKNP
What is the function of this protein?
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.  Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy.  Functions downstream of the ulk1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated.  Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes.  There, it assists wipi2 in the recruitment of atg12-atg5-atg16l1, a complex that directly controls the elongation of the nascent autophagosomal membrane.  Together with wdr45/wipi4, promotes atg2 (atg2a or atg2b)-mediated lipid transfer by enhancing atg2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes.
What are the official names of this protein?
WD repeat domain phosphoinositide-interacting protein 1, WIPI-1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Protein: EPHA8_MOUSE
Sequence: MAPARARLSPALWVVTAAAAATCVSAGRGEVNLLDTSTIHGDWGWLTYPAHGWDSINEVDESFRPIHTYQVCNVMSPNQNNWLRTNWVPRDGARRVYAEIKFTLRDCNSIPGVLGTCKETFNLHYLESDRDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRGVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACMACELGFYKSAPGDQLCARCPPHSHSATPAAQTCRCDLSYYRAALDPPSAACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALSHCEACGSGTRFVPQQTSLAQASLLVANLLAHMNYSFWIEAVNGVSNLSPEPRSAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLNHPPGKFPETQFSAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVLDALVHSPESLRATATVSRCPPPAFARSCFDLRAGGSGNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALGITLMGHQKKILGSIQTMRAQLSSTQGPRRHL
What is the function of this protein?
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation.  With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth.  During development of the nervous system also plays a role in axon guidance.  Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.
What are the official names of this protein?
Ephrin type-A receptor 8, EPH- and ELK-related kinase, Tyrosine-protein kinase receptor EEK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection. Early endosome membrane. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes (PubMed:20496116).