Protein: FSR1_GIBF5
Sequence: MASHMKLYLFGDQTFDVQPHLQHLLQKRDNLFLHEFLNQSYNALRAELFKIPYSIRKDLPRFTCQEDLLLWDQSGPRCVALDMAMTTLYQLGTFISQAGISSYDAQNSRVVGLCTGAFAAAAVSCSSFTADLIPMAVSSVVAAFRTGLLVTDTARRVDPSQDLNRSWALLVPGQKAAKAFQEFWDANDGGVLTSMPYISAYAPNGITVSGPPQRLGDLAHWLASKSITSKAIPIYSAYHAPHLYSQKDARRIVDGLMLNKAVSPSEQIPLLSSTGSKPEERSFATLLEDAIAQALLHPLRWGSIFDDVQAALETTGSQQFSVQSIGSNAEHLIYTALKKTSLRYLVPETTVPSQPTSVPSVPDAGTSKPKLAIVAMSGRFPGAKDNEAYWDLLYKGLDVHKPVPSLRWDQQTHVDPTGAGKNTSATPFGCWLDDPSEFDARFFNISPREAPQIDPAQRLALMTAYEAIEQAGIVPDATPSTRPDRVGIFYGVTSNDWMETNSAQNIDTYYIPGGNRAFIPGRINYFFKFSGPSYAVDTACSSSLAGIHLACNALWQGDVDTAIAGGTNVLTNPDYHAGLDRGHFLSRTGNCKTFDDGADGYCRGEGVATIIIKRLDDAIAENDPILGVVLGAHTNHSAESESITRPHVGAQRVIFNKILNEAAVDPYSVSYVEMHGTGTQAGDATEMSSVLETFAPPVAEGKVARPESQKLYIGSAKANIGHGEAASGVCSVIKVLQMLKKDTIVPHCGIKNKINHRFPTDLEQRNVRIAMGPTQWKKGTEINPRRVFVNNFSAAGGNSALLIQDAPPRKQLIASNDSRIQFPIAITAKSGVSLQGNMRSMLKFLSTNSHVSLAELSYTTTARRIHHQHRVLIPGATSEEICSKIETALQNNTGVTRPKAAPKVVFTFTGQGAQYPGMGKQLFEENEFVRNELLSLDRIAQNLGFPSMLPFIQSDEPDVSKFAPSLVQLASVCLQITLSKLWASWGITPTAVVGHSLGEYAALNVAGVLSDTDTLFLVGGRAQLLEQKCTRGTHAMLVVKGSQEEITEALKGQEYETACINSPIETVLAGPNEQIAKVKEQLAAASFKTTLLKVPYAFHSSQLEPMVSDIEKLAGKVTFSDPKIPILCPLEGTVIENANPFNASYLARHSRQPVNMLTALTTAYRDGYLSDRSMVLEVGPHPAVSGMVKPTLGQQITCVASLQRRRAPWDMLSAALKSLYDAGASINWVDYQSNFPGAHTVVDLPAYSWDLKEYWIQYVNDWSLRKGDPPLVINNVSKLESTTIHSVVEESGDSEKTGIVVEADIARKDLSPLVQGHEVDGIPLCTPSVYADIALTLGKYLLERYQPQQKDDMVVVSDMTVSKALILRGDGSRHPIQAHAEADWSSQSVSIKFMSFDNKGNLQEHSACVVLFKDRSHQDALQSEALTTKQKMQNLRNQITTGESARFNRPMAYRMIRPLARFHDDYRAIDEVVLNSETLEASSKISFGTVKRDGDFHTHPAVIDALTQSCGFAMNCNDHTDIDVDVYMNHGWGSLELFEPLDFEKEYTTYTQMHAGEDKLWYGDVTIFDQDRVVAFFGQIAIQGVPRRVLKVILSIESGKKGQPQRQTQDKPRNTPSQTKDSTPKPAQNKPAAKVEPPKFSTAIRIISEESGIDVSDFTDGTTFADVGIDSLLGLTISARFQEELDIDLDFNALFFEHPTVKDLRAFLGADEDVSESSSSAASDSGRDTTTTGSATPELQEEFAESAEVEFERALEIISEESGVARSDLDDETNFADCGVDSLLSLVIASRFQDTFGLNIAHEQLFMECQTVGDLKTMLAREMGLATPASKPAAIPAPVVSEAVAQETVVTHSDTSNLAEREQAITELVNKYTAGFKAPTSNPNGPPLGKNESVVLVTGASGGLGSHLVYALAQLEEVHTVVCLNRPNREDPTTRQYKAMRDKGIRFPEHLKSKVRIFQTDTSKPKLGVADSEYASLIRSVTHIIHNAWPMSAKRPLSGFESQFQVFRNLLDLGRECASNRPADFKFSFQMISSIGVVGQWGLAAGQTGKIVVPEERTTIDSLLGNGYAEAKWGCERMLDETLHKFTDRFRPMVVRLGQIAGSKTSGYWNPMEHFGFLIKSSQTLNALPDVDGNLNWTPVNDIADTLTDLILSDRTPYPIYHIDNPIGQQWRDVNNILSDTLRIPNKVPFKEWLDMVRKAPQQDNPAALLADFLEDTYLRMACGGLVLDVKHSLEHSKSLSAVGPVSETVVRKYIHIWKEIGFLKTTAEDKAGFEAERLRLWGPRV
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusarubins, highly pigmented naphthoquinones responsible for the coloration of the fruiting bodies (PubMed:22492438, PubMed:23825955).  The non-reducing polyketide synthase FSR1 is responsible for the condensation of seven acetyl-CoA units to yield a haptaketide (PubMed:22492438).  After rings A and B are formed by aldol-type cyclization, the PKS-derived product is released as 6-O-demethylfusarubinaldehyde (PubMed:22492438).  Then, two hydroxyl groups at C-5 and C-10 are incorporated by FSR3, and simultaneously hydroxyl groups at C-6 and C-8 are methylated by FSR2 (PubMed:22492438).  The aldehyde is, on the one hand, reduced by FSR3 to 8-O-methylfusarubin alcohol, which equilibrates mainly with 8-O-methylfusarubin and only small amounts of 8-O-methylnectriafurone (PubMed:22492438).  On the other hand, the aldehyde can be oxidized to form 8-O-methylfusarubinic acid, a reaction driven by FSR3 equilibrating with 8-O-methylfusarubinlactone, finally resulting in 8-O-methylanhydrofusarubinlactol after a further reduction step and loss of water (PubMed:22492438).  8-O-Methylfusarubinic acid can also undergo decarboxylation, resulting in 8-O-methyl-13-hydroxynorjavanicin after another hydroxylation step at C-13 (PubMed:22492438).  Both steps are most likely also accomplished by FSR3 (PubMed:22492438).  No enzymatic function has been determined so far for either FSR4 and FSR5 (PubMed:22492438).  Their deletion does not alter the product spectrum, but the possibility that they catalyze specific enzymatic steps during perithecium development cannot be ruled out (PubMed:22492438).  FSR4 might possess a regulatory function in the biosynthesis of fusarubins (PubMed:22492438).
What are the official names of this protein?
Non-reducing polyketide synthase fsr1, Fusarubin biosynthesis cluster protein 1, Pigmentless perithecia protein 1, Polyketide synthase 3.