Protein: VDTX1_BYSSP
Sequence: MAICGIAVRLPGGISNDAQLWDFLLAKRDARSQVPGSRYNISGYHSDSGKHGTSKSKYGYFLDESVDLGTLDTSFFSFTKLELEYIDPCQRQLLEVVRECFESAGEVNYRGKDIGCFVGSFGDDWTENLTHDEQTSAKYPLMVGGDFATPNRVSYEYNLHGPSVSIRTACSSSLVALHSACLSIQNGDCSAAIVAGFNLILTPTMTMIMSSKGVLSADGSSKSFDADADGYGRGEAVNAVYIKPLHDAIRDGNPIRAVIRGTATNSDGKSAGFTVPSADAQEDVIRKAYKAAGISDLSQTAFVECHGTGTTVGDPIEVAAIANTFGGDMYIGSVKPNVGHSEGASGLTSLIKAVLAVENRTIPPNIKFNTPNPKIPFEAKKITVPVEATPWPWNRCVRASVNSFGMGGVNAHVIIESADNFTPPTSEVIEEHDSTPQLLLFSANTQDSLEAMIQRNLAYLRENTDSLRDLVYTMGARREHLSFRAASIVHSDMSVTTASFGKAPSSPPDIVMVFAGQGAQWPGMGVELFKSNATFRRSILEMDSVLQSLPDAPAWSIADEISKEHQTSMLYLSSYSQPICTALQVALVNTLFELNIRPYAVIGHSSGELAAAYAAGRLTASQAVTLAYYRGIVAGKVAQAGYYPFLRPGVVVACENSPSSVTISGDIDQVQYVMQEISLAHPEILCRQIKSDTAYHSHHMKSVGDTYHSFINPFFRGETEVNCQPVHFFSTVTGDELSDGDHVGPKYWQQNLESRVLFQGALENIISRQRSRHLLFLDVSPHSTLAGPIRQTLEQAEVAHPYVPCLIRFKNCAESFLSTIGQLYSHRQPLDFNMLTNPDRTAKVLTDVPTYPWQHGYSNLYTTRQNNEWLFRKQPKHELLGTRVVDSTDNEPCWRNVLYLEHVTWLRDHKVSGNIVFPAAGYVMMAGEAVRQIGSTASGFIVRQMVLDTAMVLNQSNPTEIVTSLRKHRRDRWYSFTISSHNGVKWIEHCYGEVAQENLSRDINVSNWYKTLSRGGVEFGPAFQCVESQSCSVTSNTVSGRIVSKLDSVLHIVYGAIYKGFDWQVESLPVPTSIGEIMIGECVSDLDVTMWADVSRNSNILVNGEAFGSDGCLLIRIKDIVLRPLGANQACFEEDESHAGARLLWKPSMQFLNLADLIQTPVNWTKQTMLLNDFTSLCIERALCLLHAQGDWLQRQPKPSSEQSMESLVEKILATSAAPCARAMIKVLDNIVPICKGEIDALEVLMGDDTLYELYNYLNEPQQRILEIGAGTGGTTAKILPRTKYSTYTFTDISAAFFPAAKDRFQCHANVVYRTLDITKDPLDQANVLHATPNLYETLSNLLLEELCGDAKFTNFIVGVLPGWWAGESDGRADEPYISPDRWDSILKAAAPPLHSLAFMLASPSCVPESPLKRNVTLLSDVTSSEIAVRMQKQLLSRGYSVGVQSLDQSLMDGEDVIILVDTVSPFFHNLDSRKLSTFQNLLRELQRSHSGALWVTRSIQIDCRDPRYSPTLGVARTVRSEFGLDFGTCEVDTLKYTSIGLVIDVFEAFHGRRHGQNAYPEYEYAIREDTADAGQQVQLLGDDEVELQVDTAGVNFLTVLINSASDGVGLAAIQISKMIGATIYATVIGEDKVEYLTASHGIPRDHIFNSRDSSFLDGIMRVTNGRGVDLVLTSLSADFIQASCDCVANFGKLVNLSKPTAANQGQFPIDSFHPNMSYASVDIIDYIKRRPKESKRLLEEIVELYKQGHIQPITPVKTFTATDIRQCFDYMQSGQHIGQLRLSLKSQDTFIEAVCSPKTMIFQSDASYLLVGGLGGLGAEIARWMAEHGARNLIFLSRSADAESNIRLFRELESQGCSVQAIKGSVCNASDVKRAISAARIKLKGIFNMSMVLQDASLLKMSSDEWNAATGPKIQGTWNLHDASLDQDLDFFLLFSSMGGILGIPGQANYASANTFMDAFVQFRHSSHLPASVIDIGEVQGIGHVANNPEILNRLKLLECARMSQKDLFHAITIAISHSLPPQTLDYSRYENPAQFITGLRDTTGMLDSTGGKSMLLDSRLAAYVGNSAAVTAPTETKTSANKLNNFVSSAATDSAILSEPSATQFVSLEIARWVFDLLMKPVDDDSEIDLSRSLVDVGLDSLAAVEMRSWLKSSLGLDISVLEIMASPSLAAMGEHVIRELVRKFGGDNKN
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of viriditoxin, one of the 'classical' secondary metabolites produced by fungi and that has antibacterial activity (PubMed:31304040).  The first step is performed by the polyketide synthase VdtA which condenses one acetyl-CoA and 6 malonyl-CoA units to form the heptaketide monomer backbone of viriditoxin (PubMed:31304040).  The product of VdtA is then O-methylated on C7 by the O-methyltransferase VdtC.  The O-methyl group is important for the stereoselective coupling of the monomers at the final step of viriditoxin biosynthesis (PubMed:31304040).  The short-chain dehydrogenase/reductase VdtF is involved in the reduction of the C3-C4 double bond (PubMed:31304040).  The FAD-binding monooxygenase VdtE then converts the ketone group into a methyl-ester group to yield semi-viriditoxin (PubMed:31304040).  Finally, the laccase VdtB is involved in dimerization of 2 semi-viriditoxin molecules to yield the final viriditoxin.  The non-catalytic carboxylesterase-like protein VdtD affects the stereochemistical outcome of the coupling (PubMed:31304040).  The highly reducing polyketide synthase VdtX is not involved in viriditoxin synthesis, but might possibly play a role in the production of additional metabolites not identified yet (PubMed:31304040).
What are the official names of this protein?
Highly reducing polyketide synthase VdtX, HR-PKS VdtX, Viriditoxin biosynthesis cluster protein X.