PharMolix/UniProtQA huggingface dataset:
Protein: TUB1_CAEEL
Sequence: MTDTNSQWIEMNLQRQRKMLEDKQKQKRHQSAGSVRTTSTAMSMNSMKDYPTFDNSLPFSISDNSSVSVSMNTPLIPTQDPIAQPRMQSMPRQQPQQVQESLISIGDYPDNDINAKLSKVNLTSCVVSDDEDEDKRSYADSPWNTDVVADRIPSEVLPDYNFIKNNLAKFVEDPAVEHCLYKCSITRQKSGVDKGMFPTYFLHLEEFDTDKRQKIFLLAARKRKKSTTANYLLSTDPTNLSREGEGYCAKVRSNALGTQFTVYDSGQNPKKTTNHAAIRQELAAVIYETNVLGFKGPRKMTIVMPGIEPPTENRPAVRCPVRPIQDKHTLLERYRLNDLDSLKILSNKSPQWNDETQSYVLNFHGRVTQASVKNFQIIHQSSPEYIVMQFGRISDDEFTMDFRYPLSAVQAFGIAMTSFHGKLACE
What is the function of this protein?
Has a role in fat regulation independent of daf-16 (PubMed:12529643, PubMed:16462744, PubMed:17762880).  Implicated in ciliar sensory function which is required for normal sensory behavior such as chemotaxis (PubMed:16462744).  Required for extension and growth of sensory neuronal cilia during postembryonic development, potentially via mediating signaling protein transport and localization of PI(4,5)P2 to the ciliary base (PubMed:31259686).  Functions in life span control via the insulin/IGF-1 pathway (PubMed:16054097).  Thought to be involved in neuronal trafficking (PubMed:15790967).
What are the official names of this protein?
Tubby protein homolog 1.
What is the protein family that this protein belongs to?
Belongs to the TUB family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell projection, cilium.
Protein: CC014_HUMAN
Sequence: MTSLFAQEIRLSKRHEEIVSQRLMLLQQMENKLGDQHTEKASQLQTVETAFKRNLSLLKDIEAAEKSLQTRIHPLPRPEVVSLETRYWASVEEYIPKWEQFLLGRAPYPFAVENQNEAENTIQNEAQR
What are the official names of this protein?
Uncharacterized protein C3orf14.
Protein: RAVA_ECOLU
Sequence: MAHPHLLAERISRLSSSLEKGLYERSHAIRLCLLAALSGESVFLLGPPGIAKSLIARRLKFAFQNARAFEYLMTRFSTPEEVFGPLSIQALKDEGRYERLTSGYLPEAEIVFLDEIWKAGPAILNTLLTAINERQFRNGAHVEKIPMRLLVAASNELPEADSSLEALYDRMLIRLWLDKVQDKANFRSMLTSQQDENDNPVPASLQVTDEEYERWQKEIGEITLPDHVFELIFMLRQQLDKLPDAPYVSDRRWKKAIRLLQASAFFSGRSAVAPVDLILLKDCLWYDAQSLNLIQQQIDVLMTGHAWQQQGMLTRLGAIVQRHLQLQQQQSDKTALTVIRLGGIFSRRQQYQLPVNVTASTLTLLLQKPLKLHDMEVVHISFERSALEQWLSKGGEIRGKLNGIGFAQKLNLEVDSAQHLVVRDVSLQGSTLALPGSSAEGLPGEIKQQLEELESDWRKQHALFSEQQKCLFIPGDWLGRIEASLQDVGAQIRQAQQC
What is the function of this protein?
Functions as an ATPase.  May play a role in metal insertion (metal-chelatase) or as a chaperone.
What are the official names of this protein?
ATPase RavA, Regulatory ATPase variant A.
What is the protein family that this protein belongs to?
Belongs to the RavA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACYP_BURM7
Sequence: MSGDDLDERIETYYVRVRGVVQGVGFRHATVREAHALKLRGWVANLDDGSVEAMLQGSAPQIDRMLAWLRHGPPAAHVTEVTFEEHRTDKRFERFQQH
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: CS81_CONAH
Sequence: LKMGAMFVLLLLFTLASSQQEGDVQARKTSLKSDFYRALRQYDRQCTLVNNCDRNGERACNGDCSCEGQICKCGYRVSPGKSGCACTCRNAK
What are the official names of this protein?
Conotoxin Ac8.1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin S superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SAP12_ORYSJ
Sequence: MEEQQAAAAGGGGGGGGASMCANGCGFFGSEATKKLCSKCYRDQLKAAPSSPPAAPDLVANEEEEASTAAAAAADEQLALCSSGCGFFGSKETNNMCSKCYRDHLKATSPLFSSSSSPATASTTDITVPIAPATTAPTPSLKGKEEEATAAASSSAAAAAKPNRCVACRKKVGLLGFECRCGGTFCSTHRHADKHACTFDFKKSDREKIAKENPLIVAPKITKF
What is the function of this protein?
May be involved in environmental stress response.
What are the official names of this protein?
Zinc finger A20 and AN1 domain-containing stress-associated protein 12, OsSAP12.
Protein: DAPL1_MOUSE
Sequence: MANEVQVLPSPLKGRYAPAVKAGGMRISKKQEMGVLERHTKKTGLEKTSAITNVAKIQMLDALTDTLDKLNHKFPATVHTAHQKPTPALEKAAPMKRAYIIQQPRKC
What is the function of this protein?
May play a role in the early stages of epithelial differentiation or in apoptosis.
What are the official names of this protein?
Death-associated protein-like 1, Early epithelial differentiation-associated protein.
Protein: RSMH_CLOPS
Sequence: MEFKHVSVLLDECINALNIKEDGIYVDCTLGGAGHSSEIVKRLSSDGRLIGFDQDKDALKAAGERLKDYKNVTYVHSNFYAIYDVLTDLGIDGVDGILMDLGVSSYQLDNGERGFSYMQDAPLDMRMNRENEFSAYEIVNTYSEEELYRIIKEYGEEKFAKRIASFIVKNREEKNIETTLELVEIIKAAIPAKARREGPHPAKRTFQAIRIEVNKELEIISKTILDGVKKLNKGGRMAIITFHSLEDRIVKNTFKELANPCTCPSEFPVCVCNRKPEVKLISRKPIEASKEELEFNPRSRSAKLRIIEKL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_PAEAT
Sequence: MARLAGVDIPREKRLEIALTYIYGVGKTRAHETLAATGISADVRVKDLTDAELVQLRDYIEGNYKVEGDLRREVAADIRRKVEIGSYEGLRHRKGLPVRGQRTKTNARTRKGPKRTVAGKKKAGR
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: G6PI_SALHS
Sequence: MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITEETLAKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDLGPFMVTEALRPYKNHLTMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAMDKHFSTTPAEKNLPILLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGLINRYKAWRA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GET2_YEAS1
Sequence: MSELTEAEKRRLLRERRQKKFSNGGASSRLNKITGQASSHLNAESPLDAPSAAKTTPPASVHSATPDIKEDSNVAPQLDLLKQLAAMQGQGTGKSTPQDSSTPDLLSLLSSMNTGMPSAEGTPSFGQAAPAAPINQAALDYHDYLLNRLKAWTILVKWVFFLLPYLYLITRPNSSVWPAYAFTQSAWFAPLRNPSNFTRIFATFEFLSISIYYQLLKNVEHKSKIKNLQDTNKLVKLVSLVPEGVIPVANLKGKLITLLQYWDLLSMLITDISFVLIVLGLLTYL
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.  Involved in DNA replication and DNA damage response and also in cell wall function.
What are the official names of this protein?
Golgi to ER traffic protein 2, Hydroxyurea resistance protein 2, Required for meiotic nuclear division protein 7.
What is the protein family that this protein belongs to?
Belongs to the GET2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: DNCH_PROMM
Sequence: MNPENWLLLRRVVRFGDTDAAGVMHFHQLFRWCHESWEESLESYGLNPADIFPGSRKSEVTPEVALPIIHCQADFRRPIHTGDALAMELRPERLNPNSFQVHFEFRCEEQIAAHALIRHLAINAQTRHRCALPEGIDRWLEASGVGKIGSI
What is the function of this protein?
Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA hydrolase, DHNA-CoA hydrolase, DHNA-CoA thioesterase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
Protein: VATA_CLOBH
Sequence: MKTGRVLKISGPLVVAEGMEEANIYDVVKVGEKRLIGEIIEMREDRASIQVYEETAGLAPGDPVITTGEPLSVELGPGLIEAMFDGIQRPLNAIKAKAGDFITKGVEVHSLDRDKKWHFTPVKKVGDTVEAGDVIGIVQETSIVEHKIMVPYGIKGTIETIEEGDFTVVDTVAKVKDKDKVSDLMMMQKWPVRRGRPYGRKLNPAQPMITGQRVIDTFFPVTKGGTACVPGPFGSGKTVVQHQLAKWADAQIVVYIGCGERGNEMTDVLNEFPELKDPKTGEPLMKRTVLIANTSNMPVAAREASIYTGITIGEYFRDMGYSIALMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRAAEFYERAGNVVSIGSEEREGALTVIGAVSPPGGDLSEPVTQATLRIVKVFWGLDAQLAYRRHFPAINWLNSYSLYIEKISPWMDENVASDWTALRIKAMSLLQEEASLEEIVRLVGIDALSEKDRLKLEVAKSLREDYLQQNAFHEVDTYASLGKQYKMLKLVLFFYDEAQRALNAGVYLKELLDLEVRDKIARAKYISEENIENIDAIFNELSEVIDQLISKGGIMNA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: RL16_SALCH
Sequence: MLQPKRTKFRKMHKGRNRGLAAGADVSFGSFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLAVRMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFKLAAAKLPIKTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: HDEA_BRUSI
Sequence: MIKALFNKNTALAAVAILALSGGAMAESAKTHKTDMAKKKVSELTCEDFNGLEESFKPTVVGWVVGFNKKGKEEDAVIDVDGIETVTPAIIEACKQEPKASFWKKAEAELKKVF
What is the function of this protein?
Required for optimal acid stress protection.  Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins.
What are the official names of this protein?
Probable acid stress chaperone HdeA.
What is the protein family that this protein belongs to?
Belongs to the HdeA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL35_MESM1
Sequence: MMAKNKMKPKKALAKRIKISSTGKVKFGHAFRSHLAQNKSTKQKRQSKHGTFMHPTDYKRLKDLM
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: IXTPA_SALTY
Sequence: MQKVVLATGNAGKVRELASLLSDFGLDVVAQTELGVDSAEETGLTFIENAILKARHAAKMTGLPAIADDSGLAVDVLGGAPGIYSARYSGENATDQQNLEKLLHTLRDVPDDKRQARFHCVLVYLRHAEDPTPIVCHGSWPGVITRQAAGNGGFGYDPIFFVPSEGKTAAELTREEKSAISHRGQALKLLLDALRNG
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: HEM1_NEIG1
Sequence: MQLTAVGLNHQTAPLSIREKLAFAAAALPEAVRNLARSNAATEAVILSTCNRTELYCVGDSEEIIRWLADYHSLPIEEIRPYLYTLDMQETVRHAFRVACGLDSMVLGEPQILGQIKDAVRAAQEQESMGAKLNALFQKTFSVAKEVRTDTAVGENSVSMASASVKLAEQIFPDIGDLNVLFIGAGEMIELVATYFAAKNPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHDYDVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDMVNIVQSGKEARQKAAAAAETLVSEKVAEFVRQQQGRQSVPLIKALRDEGEKARKQVLENAMKQLAKGATAEEVLERLSVQLTNKLLHSPTQTLNKAGEEDKDLVHAVAQIYHLDK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: TRHO_ACIBS
Sequence: MEFSMNATVEQLAPVEQQATAGWVVAALYQFKEVQDPADLQQRLLDLVKTINLCGTLIVAGEGINGTVAGDREAIDTIHQFLLNEGFNAMEYKESHSSDKPFRKMKIKLKKEIVTLGVEVKPRDLVGHYLDPKEWNELIARDDVILIDTRNDYEYKAGTFKGAIDPKTETFREFPEYVKKELEQHKDKKIAMFCTGGIRCEKSTSLLLQEGFKEVYHLKGGILKYLEETPPDESLWEGECFVFDGRTAVTHGVEEGANIKCHACGWPLTPEESALPSYEHGVSCLYCIDKTTEKQKAGFRMRQSQIAAAKHKRL
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: PDRP_CLOBH
Sequence: MFKIYAVSDSIGETAEQVANATAYQFGSSVKVERVPYVKTFEDVNNLISIIKNPNEAMIISTIVLVDIREFLVQRCVESGIHISNVLGPCISLVSTILNKTPEYKPGAVWDMDKKYYKKIEAMEFAIRYDDSKDHSGIKHADIVLIGLSRTSKTPLSIYLANKGIKALNIPLMPEVPVPEELFEIDRKKIIGLTIDPMHLIEIRRHRVDNMMKIPTELKYANAERVLDELEFADKIMRKLKCKVIDVTKRAIEDTALIIMESVFSDRII
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: NADE_PSEPG
Sequence: MQAVQQEIAQALKVQPPFADAAALEAEVARRVTFIKGCLANARLKTLVLGISGGVDSLTAALLAQRAINELRAETGDKAYTFIAVRLPYQVQHDEHDAQACLDVIKADEVHTVDIAPAVRALAAEVVELKNGSPTLVDFVVGNVKARTRMVAQYTIAGARAGLVIGTDHAAEAVMGFFTKFGDGACDLAPLSGLVKNQVRAIARSFGAPESLVEKVPTADLEDLEPGKPDEASHGVTYQQIDAFLHGQPVDQAAFDIIVATYRKTQHKRELPFAP
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: A1AG1_MUSCR
Sequence: MALHMILVMLSLLPLLEAQNPEHVNITIGEPITNETLSWLSDKWFFIGAAVLNPDYRQEIQKMQMVFFNITPNLINDTMELREYHTIDDHCVYNSTHLGIQRENGTLSKYVGGVKIFADLIVLRKHGAFMLAFDLKDEKKRGLSLNAKRPDITPELREVFQKAVKHVGMDESEIIFVDWKKDKCGQQEKKQLELEKETKKDPEEGQA
What is the function of this protein?
Functions as transport protein in the blood stream.  Binds various ligands in the interior of its beta-barrel domain (By similarity).  Appears to function in modulating the activity of the immune system during the acute-phase reaction.
What are the official names of this protein?
Alpha-1-acid glycoprotein 1, AGP 1, Orosomucoid-1, OMD 1.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLPS_BDEBA
Sequence: MGNNKKDSNSNYPFASPEGEAGVQLVPKLDTPKMYKVILLNDDYTPMDFVVLVLRRFFAKTEEQATEIMLDVHKKGAGVAGVFSLEIAEMKVMQVNQFAQLNQYPLKSTLEEEA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: RS7_PSYIN
Sequence: MPRRRVVGTRKILPDPKFGSEVLAKFVNVVMVDGKKSIAEKIVYGALEAAASKSGKVALDLFEVALENIRPSVEVKSRRVGGSTYQVPVEVRPSRRNALAMRWLVEASRKRGEKSMALRLAGELVDASDNKGSAVKKREDVHRMADANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RS17_PROMT
Sequence: MALKEMVGTVVSDKMQKTVVVAVENRFPHPIYQKIISRTTRYKAHDAENHCKVGDRVRIKESPPISAHKRWTVTDVLVKGMKSKEAAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: MTP_RAT
Sequence: MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGKLQDSVGYRISSDVDVVLLWRNPDGDDDQLIQVTITAVNVENAGQQRGEKSIFKGKSTPKIVGKDNLEALRRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLTSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVTSKATSVTTYKIEDSFVTAVVAEETRAFALNFLQTVAGKIVSKQKLELKTTEAGPRMVPGKQVAGVIKAIDSKYKAIPIVGQVLQSVCKGCPSLAEHWQSIRKHLEPENLSNAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPASLEAILDFLDFKSDSSIILQERFLYACGFASHPDEELLQALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDASFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNNPSYMDVKNILLSIGELPKEMNKYMLTIVQDILHFEMPASKMIRRVLKEMIVHNYDRFSKSGSSSAYTGYVERSPHAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMDIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDITVDSSFVKAGLESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVPGCELPLHQENSEMCNVVFPPQPESGNSGGGWF
What is the function of this protein?
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722).  Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity).  May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).
What are the official names of this protein?
Microsomal triglyceride transfer protein large subunit.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum.
Protein: MENE_STAAN
Sequence: MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRLTPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNGLLDNTMGIQYDTSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSKHLAKYKVPKHFEKVDTLPYTSTGKLQRNKLYRG
What is the function of this protein?
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
What are the official names of this protein?
2-succinylbenzoate--CoA ligase, o-succinylbenzoyl-CoA synthetase, OSB-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
Protein: AVL9_MOUSE
Sequence: MEKSGRESDGAPCGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATVYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGASLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNRLVGALMTVLSLFPGMIEHGLSDCSQYRPRKSMSEDAGPQESNPSADDFTSESTSDVLNTSLETVTRVMAVNHGEDAVPKTEKPYFQVEGNNNKGQEPSDSGRYLELPPRPSPESSESDWETLDPSVLEDASLKEREQMGSDQTHLFQKDSLPSDSPPITVQPQANNRQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKMLSDYGTTFVAAWKNTHNYRVWNSNKHPALSEINPNHPFQGQYSVSDMKLRFSHSVQNSERGKKIGSVMVTTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTTSTPQSLPEPPNGKP
What is the function of this protein?
Functions in cell migration.
What are the official names of this protein?
Late secretory pathway protein AVL9 homolog.
What is the protein family that this protein belongs to?
Belongs to the AVL9 family.
What are the subcellular locations of this protein?
Recycling endosome. Membrane; Single-pass membrane protein.
Protein: IF4A2_PONAB
Sequence: MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
Eukaryotic initiation factor 4A-II, eIF-4A-II, eIF4A-II, ATP-dependent RNA helicase eIF4A-2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
Protein: UCRI_RICFE
Sequence: MSDTEDNKNKQTTRRDFMVLTASSVAAVGAVCTLWPLVDSLNPSADVLALSSIEVDLSNIAVGQTVTVKWQGKPVFITNRTPDKIAEARAVKMSELIDPETDEARVKAGHDNWLVTIGICTHLGCVPLANQGEYDGWFCPCHGSQYDSSGRVRRGPAPLNLAVPPYTFISDKKIRIG
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
What are the official names of this protein?
Ubiquinol-cytochrome c reductase iron-sulfur subunit, Rieske iron-sulfur protein, RISP.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SELA_CAMJD
Sequence: MNKFRTFPQINTLIQDESLKSYPFYIKAFFCKKVVAKLKENFSRDEISKDKLLLEIKKEIKTFYRKDLQSVINASGVVIHTNLGRSVIHEELYEACKDIICNYSNVEFDLENGKRGSRYALVLEKLKMLFECEDALVVNNNAAAVFLVLNSLCYDKEVISSRGELVEIGGSFRVPEVIKAAGVKLCEVGTSNKTHLKDYEQAINENTALILKTHKSNFALMGFHSEVNIKDLHELVKEKGLLSYYDLGSGWCENLNEKLIKNEPKIKKLVQECDILSFSGDKLFGSVQAGIILGKKELIGKLKQNQLLRMLRVDKLTLSFLNESLKAYLQKDYEKIITLKLLNDDLSFIEEKALRVQKELKFQTQLKKSKSLVGGGSMPDKSLDTYILTFQGDALKLQTRFRKENIIGRIENDEFVLDFRTIRENELQKLILKINQMENL
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_KLEP3
Sequence: MQILLANPRGFCAGVDRAISIVENALTLYGAPIYVRHEVVHNRYVVDSLRKRGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYNNPQGGMYLVESPEDVLKLEVKNDARLSFMTQTTLSVDDTSDVIDALRARFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGKAAYLIDDASDIQEAWVKDAACVGVTAGASAPDILVQNVITRLQELGGGEAVPLEGREENIVFEVPKELRVDVREVE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.