Protein: L_DUGBA
Sequence: MDFLDSLIWERVVDEQYITNPTFCVSDYFEVIRQPGDGNCFYHSIAELFFDVKTPSSFRKVKEHLQLAAEVYYDTEPEAVGTGISKDEYIKVAMKDNEWGGSLEASMLSKHLQTTIILWVVNSTEQVTAAIKFGPGRVSTALNLMHVGRTHFDALRIIEQLENNQPQDRNRLDIADRIAAAEVYVRQSIEDNLQEDEFFDYAREDEISEDVSAPGGSREATELKKKAILLNKTVKRGENIPIRVGRVLDCLFSCKIAVSLDEGLLYLRPETRESEATSISLRQLGHKLLTRDRHIKMEYARSKLYVTRDLIDHLDIGGLLRSSFPGLGLERYIQLLHSELVLDLVTVVLAVLLSTFLYGSNNKNKKQFITNCLLNTKLSGKRVFKALSKLTGQMLYRTPKRAVSIVSQELYGKLMLKVKNNLEGMGPISMLALRNLNFDNMQLQDYLEMLSEMSKIDNSDVEYTHREISDLHTLVERLSKLQKSQDVNELKLWFKEEVLTKRSQRSVGNAFEFLINDYFKKKDIMKFVSTSGKASSTGNIGNVLSYAHNLYLSKESLRMTSEDVTQLLIEIRKLHKLQGDLSIEPVAIICDKLEDQFRKLFRELPEECSSECQTLFNDIRNSPSHSVAWKHALRLKGTAYEGMFAKQYGWSYISEDIKPSLTMIVQTLFPESFEAFLDRTQLHPEFRDLTPDYALTQKIFFPRNTIPRTENRQLAIDVSLEGSVEAVPIVEKRMFPLPEVPIGEANSISRVMNIFKEKREESMQKKLEHDRQAEANRLKSAGLSASKAEQEVCNSAQDRKEEKERTTEPAGKQQRTEDLVVIEGNQDEGDSDPQKKVDEKTVPGESKQHSKSSGSSSTNQMSQKVVDVPSVEDSSDQAPGDFPDYGYYFKRIVMDESGTVLTEEAQLEKRQLLFIEVGYQTDVDGKITTDYKKWKDILRLLELLNIKCSFIACADCSSTPSNNWWISEDKVRLLKNSISHLFSKLTQNSPADVTDIVVGSISTQKVRSYLKSGTATKTPISLKDVQETWSKMKDYIVNRPTGISLNKELVGALYQGLVEGAIISKEGTVNLIQMLKDKQERITDEFERTKLKHEVNEDVKTSEKLLLGWLMEDLKGCRCMGCLTKIKELSESMSVNQDRLEYLSTNCQTKSHCTECHPRSLEYRNISNVDNRVPSMQRVSHSRNEGFEDTNETLTELDRLVRLTLPGKTEKERRVKRNVEGLIRFMMQQSSLDCIKLPSGQIIAHRCSKKFKNSSEAEEKCNERFERLMKELSEQKLKPYSDHVRKTITSSLKKTDKQAGSKCAVPRLWLETLIRDLRVPTKDEEILLNIRTSMQSKTNFIRNNDKLIIRSNKEIADYLETKRKNLLSEKASDKIFSSDCILFKEVIAEALRRYYSTPYEGVPETIVKLINFLCTFGWFQEVVLYSKICETFLRCCTEFSRSGIKLVKVRHCDTNLSIKLPSNKKENMLCCLYDKNMSLLKGPFFLNRRQAILGSAYPYILITLYIQVLQQHRCLEVLNSVNDRVVGNINTCTSNLLNTVKAELTLVNSGLFEKAYECRTEQCRLGGNFLNRSSRDHFISTVSGLNVVYGALIKDNLLANSQPQNKQLQMLRFGMLCGLSRLSSALELGKKFSTSCRRIEDNIMRLYLQSTIYSANRDVSQNVQNWKMKDLCPDITIPCFSVYGLFVNSDRQRIFDIYNVHIYNKEMDNFDEGCITVLEETAERHMLWELDLLRSLEGDTRDVRAARLLLGCPNIRKATDKDGNRLMKKGITDDWREEAGSDSSSISGRRSYASSGTRVKSMFGKYNSSQKPFELKPGLEVVNDPLHDYKQAVQDSFCYSEYTPNTESVLKDCIHIIRTNPSHTMGSYELIQAVTENARRKYPPENIERARKDPKNWVSISEVTETTSIVSQPRTHFMLKDCYKVLLGTENKKIVKMLRGKLKKLGAMRTDIEIGKKDCLDLLTTVDGLSEEQCKNIVNGIFEPSKLSFYHWKDLLKKELSEVLLTDDGNYIYCWLKTLSSMVKHSLKKDLRFMTGKNSLDIKPEMFTDEEYSALNIMKLELLGEHTDGIQGKTDFLLSSWKKCALKPKEGQSILNVGLNSLAALHDELYDIRLQHLELTRIKKENPTVSFTKEEILVKRLEKGFLNKYKKEVMEAVNLIFYCCLTAPWCLHYKSLEAYLVRHPEILETECIKENDIPLLDLTVTSLIRSLIDDIEGESSFNDSSDIKVRFAVKYLITLFTANGEPFSLSLNDGGLNDDLQLTTDEKLLYQTKKVFAKLGLSGNNYDFIWTLQMIANSNFNVCKRLTGRTTGERLPRSVRSKVIYEMVKLVGETGMAILQQLAFSQALNYDHRFYAVLAPKAQLGGSRDLLVQETGTKVIHATTEMFSRNLLKTTSDDGLTNPHLKETRLNIGLDMLSTARALDGKQVSDDSNLLNFFKTVCISGDNTKWGPIHCCSFFSGMMQQLLKDVQDWSSFYKLTFIKNLCRQIEIPAPSIRKILNVLRFKLSDKGGVEKLSEEAIRSELINNLAEWEGNDTVKFLITTYISKGIMAMNSYNHMGQGIHHATSSLLTSMMAETFEELAVDYMKKHFPGLTVNVDHAGSSDDYAKCIIVSGLVSKDMYKRYDGVFWRHMCRLKNFLAAVRRCCQMKDSAKTLVGDCFLEFYSEFMMGNRVTPAVIKFIFTGLINSSVTSPQSLVQACHVSSQQGMYNSVPLVTNAAFTILRQQIFYNHVEDFIRRYGLITLGAVSPFGRLFLPRFSGLVSSSVALEDSETISKAAAEINSNDIFFNTSSLSNLDKLEQSPDSSGLDDDSVVSTTTVESSDSKGSSSSFTFDLNRPLSETEVKFLKLLRELTSTTACEMLQEKINTLYNDSREGPLDRHNILQNCRLSESCDWLLDGKKRGLLELSRRMSCLLNVLIAGYYRSFGSEGTEKQVKASWSRDDNRVIEDPMIQLIPEKLRRELERLGLSRMEVDELMPAVGPDESLSQLVAKKLISLNVSTEEYSAEVSRLKQTLTARNVLHGLAGGIKELSLPIYTIFMKPYFFKDNVFLDLEDRWSSRHSTNYRDSTGKMLTGKVVTKFTHWLDTFLSCVVSANRSQEIKECSLFNPNLRCVNIMVKGNGIKELSYIRSHLSVLSVEFENLNLQFSDVNRQKLKIVESRPPECELEANKAVIIKSKLFSAVEHVRLSNNPAVVMGYLLEESSISEVKPTKVDFSNLLKHRFKLMQFFPSVFTLLRSLQSESKELEKLGEPVDMHQVSKYANHLTLLCRMIQQSKPSLTVFYMLKGSQMNTEPTVSELVSYGIKEGRFLKLPEIGLDASTYSVRYWKILHCISAIGELPLSSEDKTSLLISFLNWKVTSDCVDDCCPLEKYDKAIVSEFSGQVLINTLASELSSVRKDQEREGLTDLIDYINSPSELLKKKPYLGTTCRFQCWGEGAKSGKFTYSSRTGEAIGIFVAGKLHIHLTSDSPGLLCEVERQVLSWLGKRRTDVLTKEQHQFFLDFLPNLSEVVQKNRDGAILGVTIDSTNVRMLKYVPPKRNTPVIKIKKQILTVKKQTTLDVESEPRIVWGHGQLSIVYDECETETTYHENLIKVKKLVDLASGTTDKLPTAIFSDTRITLARVKFKTELLLNSLCLLHCFLKHTSQDAIQEVESKCNVLERYLRSGGVQFRPMSESLDKKVTKLPLQCQSDKDVDKEINFCEDLTRVFSNENVPLSSWSEVQSYIEEVGFGNVLVHIEKNPTRSDLIWRFSIDSISGNFGPIKDIRTLVTYMSTETVPKFLLPFLLFEEQLKHLIAGCVELRDALNSSGINDREIAIVALFTCFYYQSDSVKRQGPVCSISSFCSLIGDDLLPLDNRLQARVLPEQDNVKLHFKLNLTTDSALGKKDKAIQAKKIISRYLRLIFTEDDMDLKRLKSDATKVKLSSEKECEFLEFCLHSDLSYALNYRVLLEHLIDLEDRAKKTACVLIEEFILMLTGRLMISSTIDSDSKRTLEDDALCLEDLLDSDNEASSSKSDNEEQIALQTGKFNFNWDSD
What is the function of this protein?
Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities (PubMed:23345508).  RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome (By similarity).  During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral transcription (By similarity).  The deubiquitinating and deISGylating activities specifically cleaves poly-ubiquitinated conjugates and ISG15 from RIG-I, interfering with antiviral signaling pathways mediated by NF-kappaB and IRF signalings (By similarity).  Favors K48 poly-Ub linkages (PubMed:23345508).
What are the official names of this protein?
RNA-directed RNA polymerase L, Protein L, Large structural protein, Replicase, Transcriptase.
What is the protein family that this protein belongs to?
Belongs to the Bunyavirales RNA polymerase family.