PharMolix/UniProtQA huggingface dataset:
Protein: KANL2_HUMAN
Sequence: MNRIRIHVLPTNRGRITPVPRSQEPLSCAFTHRPCSHPRLEGQEFCIKHILEDKNAPFKQCSYISTKNGKRCPNAAPKPEKKDGVSFCAEHVRRNALALHAQMKKTNPGPVGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGEQEPITVDQTWRGDPDSEADSIDSDQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHRQLKERRMLATDGAAQQAHTTRSSQRCLAFVDDVRCSNQSLPMTRHCLTHICQDTNQVLFKCCQGSEEVPCNKPVPVSLSEDPCCPLHFQLPPQMYKPEQVLSVPDDLEAGPMDLYLSAAELQPTESLPLEFSDDLDVVGDGMQCPPSPLLFDPSLTLEDHLVKEIAEDPVDILGQMQMAGDGCRSQGSRNSEKASAPLSQSGLATANGKPEPTSIS
What is the function of this protein?
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
What are the official names of this protein?
KAT8 regulatory NSL complex subunit 2, NSL complex protein NSL2, Non-specific lethal 2 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: UCRI_PANTR
Sequence: MLSVAARSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLDLKRPFLSRESLSGQAVRRPLVASVGLNVPASVCYSHTDVKVPDFSEYRRLEVLDSTKSSRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).  UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer.  One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS) (By similarity).  The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function (By similarity).
What are the official names of this protein?
Cytochrome b-c1 complex subunit Rieske, mitochondrial, Complex III subunit 5, Cytochrome b-c1 complex subunit 5, Rieske iron-sulfur protein, RISP, Rieske protein UQCRFS1, Ubiquinol-cytochrome c reductase iron-sulfur subunit.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: RISB_MICLC
Sequence: MSGAGAPTFTPDPAAASGLNVAIVAAQWHTEIMDGLIAGAQAAAADLGLEPVLVRVPGTVELTVAAARLAERFDVVVVLGVVVRGDTPHFDYVCQSVTQGVTEVSVRTGVPVGFGVLTVDTEQQARDRAGLPGSREDKGREALEAAVLTELALRRAGA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: HIS5_NEIG1
Sequence: MQTAIIDYGMGNLHSVLKSVRTAGQLAGKNTKIFLSGDPDRVSRADKVIFPGQGAMPDCMAALTRGGLDEAVKDALKNKPFFGICVGAQLLFDHSEEGNTDGLGWFGGKVRRFARDLRDPQGCRLKVPHMGWNTVRQTQNHPLFQGIPQNTRFYFVHSYYFAPENPETILGESDYPSPFACIVGKDNVFATQFHTEKSHDAGLTMLKNFLNW
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TLR2_GIRCA
Sequence: MPRALWTAWVWAVISLSTEGASDQASSLSCDPTGVCDGHSRSLNSIPSGLTAGVKSLDLSNNEITHVGNRDLQSCVNLKTLRLGANEIHTVEEDSFFHLRSLEYLDLSYNRLSNLSSSWFRSLYVLKFLNLLGNLYRTLGETSLFSHLSNLRTLKVGNSNSFTEIHEKDFTGLTFLEELEISARNLQIYAPKSLKSIQNISHLILHLKQPVLLLDILVDIVSSLDYLELRDTNLHTFHFSEASISEMNTSVKKLIFRNVQFTDESFVEVVKLFNYVSGISEVEFDDCTHDGIGDFRALALERTRYLGNVETLTIRKLHIPQFFLFQDLSSIYSLTGKVKRVTIENSKVFLVPCLLSQHLKSLEYLDLSENLMSEETLKNSACEHAWPFLQTLVLRQNRLKSLEKTGELLLTLKNLTNLDISKNNFLSMPETCQWPGKMKQLNLSSTRIHSLTHCLPQTLEILDVSSNNLDSFSLILPQLKELYISRNKLKTLPDASFLPVLSVMRISRNIINTFSKEQLDSFQQLKTLEAGGNNFICSCDFLSFMQGQQALARVLADWPDDYWCDSPSHVRGQRVRDARLTLSECHRTAVVSAVCCALFLLLLLTGVLCHRLHGLWYMKMMWAWLQAKRKPRKAPRRDICYDAFVSYSERDSYWVENLMVRELEHFDPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIDKKAIPQRFCKLRKVMNTKTYLEWPMDETQQEGFWLNLRAAVRS
What is the function of this protein?
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components.  Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).  May also promote apoptosis in response to lipoproteins.  Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway.  Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
What are the official names of this protein?
Toll-like receptor 2.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.
Protein: CA11B_CONQU
Sequence: MGMRMMFTMFLLVVLAITVVSFTSDHASDGRNTAANDKASKLMALRNECCDNPPCKSSNPDLCDWRS
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity).  Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity).
What are the official names of this protein?
Alpha-conotoxin-like Qc1.1b, Qc1.3.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYI_THEKO
Sequence: MIREPEFREYNPGQLEEKIEAFWKENNTYEKVKKLRENGPKYYFLDGPPYVSGAIHLGTAWNKIIKDMIIRFRSMQGYNVRRQPGFDMHGLPIEVKVEQALKLKNKREIETKIGVDNFIKKCKEFALNNLKIMTEQFKQLGVWMDWDNPYMTIKNEYIESGWFTLKRAWEKGLLEKDKRVLHWCPRCQTALAEHEVRGEYKMRKDPSIYVKFPIEWKEKEYLLIWTTTPWTLPANLAVAAHPEYEYAKVKVETENGEEYWIMAKALVERVLSEVGVKGEIVETFKGEELEGIRYTHVLLEEYPAQKEFREKYEWAHRVILGEHVTLEDGTGLVHTAPGHGEEDFEVGQRYGLPVYSPVDDAGRYTEGKWKGVYVKDADPEIIEYLKEKGYLVKAGEIEHKYPHCWRCKTPLIFRATDQWFLKVSKVKDQIIKENDEKVTWYPEWVKVRYDNGVMNSGDWVISRQRYWGIPLPIWESEDGEYYVVGSFEELVKLAVAIEVNGERIDLPEGYEEKLKIIEEKLGPEDLHRPYVDAFIIKVNGKEMKRVKDVVDVWFDSGIASWASLDYPRNKELFEKLWPADFIVEGEDQVTKWFYSQQAASVIAFDTVPYRAVAMHGYVLDEKGDKMSKSLGNIIRPEEVVQKEGRDPFRFYMLWATNPWENLRFSWKGLEQVKRMLNILWNVYVLSATYMSLDNFNPTKVNPEELPFREEDRWILSRVNSLIGEVTDGIETFRLTRATRGIYNFVVEDLSRWYIRLIRKRMWVEGDDPDKLAAYYTVWKVFDVLLRLMAPFTPYIAEEIYQNLIRPFVGVESVHMLDWPEADEKAIDEELEKEMEYARKIVEAGSSARQKARIKLRYPVRRIIIETEDETVKKAVERINRILRDQLNAKEVVVGKVERELIIKPNFAKVGPEFKGDAKKVIAWISEHGRELYEKGEMDVEIEGKTFHITREHVTIEEKLPDFFVAEEFDGGRVFVDKTLTRELLAEGLAREFVRRIQEMRKRLDLDVNDRIVVTIETTDENRELLQENLDYIMRETRAVEVRFEEAKGYVVEWPEVQAKIGIEKV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_AZOC5
Sequence: MIIAIDGPAASGKGTLGKRIAGHLGLAHLDTGLLYRAVGAACLAAGKLDDEAASVEAARTLDVTTLDPESLRTGAIGEAASVVAARPGVRAALVDLQRRFAARPEGAVLDGRDIGSVICPDATVKLFVTASPEVRAERRFKELAARDPLASYEAVLADIHKRDERDSNRAAAPLVMASDAVLLDTSHLGIEESFAAALAIVERARG
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN410_HUMAN
Sequence: MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLSLLPVTEASECSRLMLPDDTTNHSNSSKEVPSSAVLRSLRVNVGPDGEETRAQTVQKSPEFLSTSESSSLLQDLQPSDSTSFILLNLTRAGLGSSAEHLVFVQDEAEDSGNDFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQSKDSGPLPQVEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHHLQLGAAGSQEQEQTAEPLMGSSLLEEASVPSKNLVSMNSQPSLGGESLNLPNTNSILGVDDEVLAEGSPRSLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQELLNQGDLTERRT
What is the function of this protein?
Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416, PubMed:33301730).  Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416, PubMed:33301730).  May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286).  May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215).  However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33859416, PubMed:33301730).
What are the official names of this protein?
Zinc finger protein 410, Another partner for ARF 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Directly binds to the sequence motif 5'-CATCCCATAATA-3'.
Protein: RL17_RHIME
Sequence: MRHGKAGRKLNRTASHRKAMFANMAASLIEHEQIVTTLPKAKEIRPIVEKLVTLGKRGDLHARRQAISQIRDVAVVSKLFDAIASRYATRNGGYLRIMKAGFRQGDNAPLAVIEFVDRDVDAKGSKDRARVSAEAEAAEAA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: QUEF_PORG3
Sequence: MTGIREGEKELSLLGSKTEYRNDYAPEVLEAFTNKHQENDYWVRFNCPEFTSLCPITGQPDFATIYINYIPDVKMVESKSLKLYLFSFRNHGAFHEDCVNIIMKDLIALMQPRYIEVWGDFTPRGGISIVPFCNYGKPGSRYELLAEKRMETHH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HELS_HALMA
Sequence: MDVADLPGVPEWLPDHLRDDGIEELYPPQAEAVEAGVTEGENLVASIPTASGKTLIAELAMLSSVARGGKALYIVPLRALASEKQADFEEFEQYGLDIGVSTGNYESEGGWLADKDIVVATSEKVDSLVRNDAPWIEDLTCVVTDEVHLVDDGERGPTLEVTLAKLRRLNPDLQTVALSATIGNAEALATWLDAGLVDSDWRPIDLQKGVHYGQALHLEDGSQQRLSVQNNEKQTAAIVRDTLEDDGSTLVFVNSRRNAEAAAGRLANTVRPHLSTEERDQLADIAEEIRDVSDTETSDDLADAVADGAAFHHAGLSRGHRELVEDAFRDRLVKVVCATPTLAAGVNTPSRRVVVRDWRRYDGSAGGMAPLSVLEVHQMMGRAGRPGLDPYGEAVLIASSHDEVDELFERYVWADPEPVRSKLAAEPALRTHILATVASGFARSRKGLLEFLEQTLYASQTDDSGQLERVVDDVLTYLQRNDFLEIEAGELDATSLGHTVSRLYLDPMSAAEIVDGLRDWERGASDSTSASGSPADAQAEPPANSGFTTASELAEDADESDADRDPDDISALGLYHLVSRTPDMYQLYLRSGDREEYEMELFEREEELLGPTPSEFEEGRFEDWLSALKTARLLEDWATEVDEATITDRYGVGPGDIRGKVETAQWLLGAAESLASEVDLDAARAISEARIRVEHGVREELVDLAGVRGVGRKRARRLFQAGITDRAQLRDADKAVVLAALRGRRKTAENVLENAGHRDPSMEGVEPAPDVSVDLNDGADGDASAESTANDDQASLGDF
What is the function of this protein?
DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
What are the official names of this protein?
ATP-dependent DNA helicase Hel308.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Hel308 subfamily.
Protein: MSRA_SACD2
Sequence: MSLFYAKPEKAKMPTEKTALKGRNVPIETAAEHFVSGMPLAPPYPSNMQQCVFGLGCFWGAERKFWQLPGVYVTAVGYSAGFTPNPTYEEVCSGSTGHNEVVLVVYNPSQVSFKKLLAVFWESHNPTQGMRQGNDLGTQYRSGVYVYSDEQAEQAEHSKQVVQAMLTEKGYGEITTEIIKAKEFYFAEAYHQQYLAKNPNGYCGLGGTGIVVPCD
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: ADD_SHIBS
Sequence: MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHKLPVAGVVEAVIDGVREGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLFLSHFNLARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVAELAAHPLKTFLEHGIRAGINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: KAD_CUPPJ
Sequence: MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGVEAKKVMDAGGLVSDDIIIGLVKDRLKDADCKNGYLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHVKYNPPKTEGVDDETGEALIQRDDDKEDTVRKRLDVYSQQTRPLVDYYSDWAAKGDATAKVSPPKYRKIAGVGDVDSITARVFEALK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_PSET1
Sequence: MTANIIDGKAIAKQVRSAVAQRVSERVAQNLRAPGLAVVLVGLDPASQVYVGSKRKACEEVGFISKSFDLPANTTEQTLLELIDELNNDQEIDGILVQLPLPEGLDVEKILERITPHKDVDGFHPYNIGRLAQRMPALRPCTPKGIITLLDSTGVRYKGLHAVVVGASNIVGRPMALELLLAGCTTTVCHKFTQDLETHVRRADLLVVAVGKPEFIPGDWVKEGAIVIDVGINRLDSGKLVGDVEYSVAEQKADFITPVPGGVGPMTVASLIENTLEACEKYHS
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CYB_MALRE
Sequence: MPHHYILTLFGLLPVATNISTWWNFGSMLLTCLALQVLTGFFLAVHYTANINLAFSSIIHITRDVPYGWMMQNLHAIGASMFFICIYIHIARGLYYGSYLNKETWMSGITLLITLMATAFFGYVLPWGQMSFWAATVITNLLTAVPYLGTSLTTWLWGGFAINDPTLTRFFALHFILPFAIISLSSLHVILLHEEGSSNPLGTNPDIDKIPFHPYHSYKDFLLLTLMVLSLFIIVSFFPDIFNDPDNFSKANPLVTPQHIKPEWYFLFAYGILRSIPNQLGGALALVMSIMILFTIPFTHTANLRPMTFRPLYQLMFWTLVSTFITITWAATKPVEPPFITISQVTSTLYFTFFISIPFLGWMENKMMHLN
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: THB_SHEEP
Sequence: MTPNSMTENGLPAWDKPKPCPDGEPEWKLVGMSEACLHRKSHPERRGPLKHEQSPLIQASWTSSIFHLDHDDVSDQSAPSAQAFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQRSMGHKPEPTDQEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRRQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRRNS
What is the function of this protein?
Nuclear hormone receptor that can act as a repressor or activator of transcription.  High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
What are the official names of this protein?
Thyroid hormone receptor beta, Nuclear receptor subfamily 1 group A member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y582_RHIEC
Sequence: MAAGDFRLCDVVLDDTIGRSTPDVEHERAVAIFDLIEENRFEPLGHSGGPYRLNISLMDSKLVFAIKTEEGGDVATHILSLTPFRRIVKDYFMICESYYEAIRSATPSRIEAIDMGRRGIHNEGSQTLKDRLAGKIEVDFDTARRLFTLVCVLYWRG
What are the official names of this protein?
UPF0262 protein RHE_CH00582.
What is the protein family that this protein belongs to?
Belongs to the UPF0262 family.
Protein: HIS1_BURM1
Sequence: MTAPLTLALSKGRIFEETLPLLAAAGVQVAEDPETSRKLILPTTDPNLRVIIVRASDVPTYVEYGAADFGVAGKDVLVEHGGSGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLKANNLVEVEEIMAISSRLVVNQAALKLKRAALKPFLDAFERASQNGV
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_KLEP3
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLAQGGHLTHGSPVNFSGKLYNIIPYGIDESGKIDYDDMAKQAQEHKPKMIIGGFSAYSGIVDWAKMREIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGSEELYKKLNSAVFPSAQGGPLMHVIAAKAVALKEAMEPEFKVYQQQVAKNAKAMVEVFLNRGYKVVSGGTENHLFLLDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRIGSPAVTRRGFKEAEVKELAGWMCDVLDNINDEAVIERVKGKVLDICARFPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PERI_HYDVU
Sequence: MFMKIIFISSVIILAAADEFIESEDQYDLNINPPKEEYKNQYESNNEYQPTSEYNNNKKPSKTDYENQYESSNKYQPKSGYKPKKVICLDIDVTKQCKNRADGNYAIDNKPRAGYIACVNKSPICMPCPYGLTFCAKTGYKGLGHCLGEYDECQSRSY
What is the function of this protein?
Antibacterial peptide.  May also be active against virus, since it is induced by dsRNA.
What are the official names of this protein?
Periculin-1, Hydraporin-1.
What are the subcellular locations of this protein?
Secreted.
Protein: GLO3_ORYSI
Sequence: MELITNVSEYEQLAKQKLPKMIYDYYASGAEDQWTLKENREAFSRILFRPRILIDVSRINMATNVLGFNISMPIMIAPSAMQKMAHPEGELATARAASAAGTIMTLSSWSTSSVEEVNSAAPGIRFFQLYVYKDRNIVRQLVRRAELAGFKAIALTVDTPRLGRREADIKNRFNLPPHLVLKNFEALDLGKMDKTNDSGLASYVASQVDRSLSWTDVKWLQTITSLPILVKGVMTAEDTRLAVESGAAGIIVSNHGARQLDYVPATISCLEEVVREAKGRLPVFLDGGVRRGTDVFKALALGASGVFIGRPVLFSLAVDGEAGVRKVLQMLRDELELTMALSGCTSLAEITRNHVITDSDRIRRSRL
What is the function of this protein?
Catalyzes the oxidation of glycolate to glyoxylate, with a reduction of O2 to H2O2.  Is a key enzyme in photorespiration in green plants.
What are the official names of this protein?
Glycolate oxidase 3, GOX 3, OsGLO3, Peroxisomal (S)-2-hydroxy-acid oxidase GLO3, Short chain alpha-hydroxy acid oxidase GLO3.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: PILS1_ARATH
Sequence: MSLTQSAKLHIIHQSIGKITTRLYDTSPFHGDSHCKQRRVKDNCIQFNMNISNVLKCYSEIESFSINQRIRRSISLFLSILRSFYSMRMRLLDLFITSSIPVAKILLITGIGFYLALDQVNILNHDARKQLNNIVFYVFSPSLVASSLSETITYESMVKMWFMPLNVLLTFIIGSFLGWIVIKITKPPSHLRGIIVGCCAAGNLGNMPLIIIPAICNEKGSPFGDPESCEKFGLGYIALSMAIGAIYIWTYVYNLMRMLANPAGETAINSTSSTMPLISPKVEVAEQVGTWGKVKQRVCSVAEKINLRTIFAPSTIAALIALAVGLNPLLRKLLVGNTAPLRVIEDSVSLLGDGAIPVLTLIVGGNLLNGLRGSGINKSVIMGVVVVRYLLLPILGVFIVRGAHYLGLVTSEPLYQFVLLLQYVVPPAMNLGTITQLFGSGESECSVILFWSYALASVSLTVWPTFFMWLVA
What is the function of this protein?
Involved in cellular auxin homeostasis by regulating auxin metabolism.  Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
What are the official names of this protein?
Protein PIN-LIKES 1, Auxin efflux carrier-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the auxin efflux carrier (TC 2.A.69.2) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TRX1_EBVB9
Sequence: MKVQGSVDRRRLQRRIAGLLPPPARRLNISRGSEFTRDVRGLVEEHAQASSLSAAAVWRAGLLAPGEVAVAGGGSGGGSFSWSGWRPPVFGDFLIHASSFNNAEATGTPLFQFKQSDPFSGVDAVFTPLSLFILMNHGRGVAARVEAGGGLTRMANLLYDSPATLADLVPDFGRLVADRRFHNFITPVGPLVENIKSTYLNKITTVVHGPVVSKAIPRSTVKVTVPQEAFVDLDAWLSGGAGGGGGVCFVGGLGLQPCPADARLYVALTYEEAGPRFTFFQSSRGHCQIMNILRIYYSPSIMHRYAVVQPLHIEELTFGAVACLGTFSATDGWRRSAFNYRGSSLPVVEIDSFYSNVSDWEVIL
What is the function of this protein?
Structural component of the T=16 icosahedral capsid.  The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes.  These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2.  Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.
What are the official names of this protein?
Triplex capsid protein 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae TRX1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.