PharMolix/UniProtQA huggingface dataset:
Protein: ATPG_PSEAE
Sequence: MAGAKEIRSKIASIKSTQKITNAMEKVAVSKMRKAQMRMAAGRPYAERIRQVIGHLANANPEYRHPFMVEREVKRVGYIVVSSDRGLCGGLNINLFKSLVKDMSGYREQGAEIDLCVIGSKGASFFRSFGGNVVAAISHLGEEPSINDLIGSVKVMLDAYLEGRIDRLFVVSNKFVNTMTQKPTVEQLIPLVADDDQELKHHWDYLYEPDAKSLLDGLLVRYVESQVYQAVVENNACEQAARMIAMKNATDNAGELISDLQLIYNKARQAAITQEISEIVGGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MTNB_BACAH
Sequence: MKQLFRQWYDLSEIKKELTTRNWFPATSGNISIKVSHEPLTFLITASGKDKTKTTPDDFLLVDHLGVPVLETELRPSAETILHTHIYNNTNAGCVLHVHTTDNNVITNLYSDAVTLQNQEIIKALDIWEEGATIHIPIIENHAHIPTLGENFRKHIQGDSGAVLIRNHGITVWGRDSFDAKKRLEAYEFLFQFHIKLLSIQGGVSNGANSYS
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: NEUFC_MOUSE
Sequence: MLRICGLGVVLSLAVAAVAVMAVWLMDWWGPRPGIRLFLPEELARYRGGPGDPGLYLALLGRVYDVSSGRRHYEPGAHYSGFAGRDASRAFVTGDYSEAGLVDDINGLSSSEILTLHNWLSFYEKNYVFVGRLVGRFYRKDGLPTSELTQVEAMVTKGMEANEQEQREKQKFPPCNSEWSSAKGSRLWCSQKSGGVHRDWIGVPRKLYKPGAKEPHCVCVRTTGPPSDQQDNPRHSNHGDLDNPNLEEYTGCPPLATTCSFPL
What is the function of this protein?
Heme-binding protein which promotes neuronal but not astrocyte differentiation.
What are the official names of this protein?
Neuferricin, Cytochrome b5 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b5 family. MAPR subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GCSH_COXBR
Sequence: MAEFPAELYYSKNHEWMRKESDETFTVGITDHAQEQLGDLVFVELPETNIHVDAGDEVAVVESVKTAADVYSPLSGKVIEINNALENEPATVNRDPYGDGWLYRITIDDEKELNDLLDADGYQTLIEAES
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: SYL_VARPS
Sequence: MNPSYKPSDVESAAQAQWSAADAYRVTEDASRKKYYACSMLPYPSGKLHMGHVRNYTINDMLTRYLRMSGYNVLMPMGWDAFGLPAENAALKNGVPPAKWTYENIDYMRGQLQAMGLAIDWSREIATCDPSYYKWNQWLFLKMLEKGIAYRKTQVVNWDPVDQTVLANEQVIDGKGWRTGATVERREIPGYYLKISDYAEELLEHTQHKLPGWPERVKLMQENWIGKSEGVRFAFTHDIQDASGRLIQDGRMYVFTTRADTIMGVTFCAVAPEHPLAAHAATLDPKVAAFIEECKSGGTTEAELATQEKKGVPTGLTVKHPITEEQVPVWVGNYVLINYGDGAVMGVPAHDERDFAFANKYGIEIIQVVLVDDEPHFDYHRWQDWYGDKQRGVTINSDNFSGMTHKEAVAAVAHALAQKGLGEMQTTWRLRDWGVSRQRYWGTPIPIIHCDEHGAVPVPEKDLPVVLPTDCVPDGSGNPLAKHEGFHAGVVCPVCGKPARRETDTMDTFVDSSWYFMRYCDPKNEQAMVAEGADYWMPMDQYIGGIEHAILHLLYARFWTKVMRDLGLVKVDEPFSKLLTQGMVLNHIYYHRDEKGGKNYHPPLEVTPTLDAQGRIVGGTTADGTKIEYGGVGKMGKSERNGVDPQDLIEKYGADTARLYTMFTAPPEATLEWNDAAVEGSYRFLRRVWNFGVAQADVAPVAFGGQAFGKAAQALRREVHTVLRQVDYDYQRMQYNTVVSGAMKLLNALEGFKPDGSAGDAAALREGLGILLRCLYPATPHITHQLWQHLGYDKELGDLLDAPWPVVDVAALEQDEIELMLQVNGKLRGALRVPAGASKAEIEALALSCDDFVKFAEGAPAKRVIVVPGRLVNVVI
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRVP_BOTFO
Sequence: SVDFDSESPRKPEIQ
What is the function of this protein?
Weakly blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction.  May target voltage-gated calcium channels on smooth muscle (By similarity).
What are the official names of this protein?
Cysteine-rich venom protein Bfon12, CRVP, Cysteine-rich secretory protein, CRISP.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: UD2A2_HUMAN
Sequence: MVSIRDFTMPKKFVQMLVFNLTLTEVVLSGNVLIWPTDGSHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKGGFDVLVADPVTICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEWNSYYSKILGRPTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKNGVVVFSLGSMVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKKRE
What is the function of this protein?
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:19858781, PubMed:18719240, PubMed:23756265, PubMed:23288867).  Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:19858781, PubMed:23756265).  Catalyzes the glucuronidation of endogenous estrogen hormone estradiol (PubMed:18719240, PubMed:23288867).  Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265).  Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781).
What are the official names of this protein?
UDP-glucuronosyltransferase 2A2, UDPGT 2A2.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: BFD1_TOXGM
Sequence: MEGASTQPMPHSQRERQAPVHAISGTWENCDQAGEYKGTACCVVERQVYSTETHAVEGCCSTRWNGVKEEKGGGEVSSRTALAGVVHLYTNSDGNAYTHISDQGMRQDEAVAGQEQRHLNCEGEHEKKGNVAAGGGTLMVTKSEIEPCDDYYSVQRGQSCAGERAPRDGCCRLLDGSRVDPAEGGSEEDENCYTHVLQKHLGQMPTAPYQGDDRLQTDLRLGDFQSGPSDALSGHHVTRTPILSPHGRYSEYISERLAWQYAERPGHGIAAENTVVMHSHTGEATGSLRADAPSQWSTESRLQFHVGSQFTTENPELFAGIVGLDTEQFDARNAEALHWRQQGEARSTETECIADITPERGNRSTIRQWNKPEAARQEYHRASASARGPEETNIITRGAHSDDQSIDAAAPGCWAARHLTSRQHPNPRPRMKEEHCGREREVLSSEQPSDCGETQKTPASHSLVLDSKSRADASQTSPYTRNDEIQTIRAFEEQCLEVQLPQSRLRRGIDYEAGMSQLAPTTQELKAKVLTTGLSPSCPNAAVLRASVPLSMDTTVTVHLADVEDPSSKRHTPIENSISSGHCDPPCSSPGGMMEPRVSVSGLGSPHNCVEDREIARHGDGIGRDILERRPLPFSPAALLTGCSSTAASSVVSGDVFTSVAASARANACRSSTDTQEESGCGDAPRYVLLFPDEQDERLGHAQTSIATPSGSGQSKCMFKGDGNAEATFREEVKSSELRTPSRIQTRRLLPGVQLQGMDCDGCGASDPQKGRPAPETGFLPEICHFSPQHPWQPGSEVNQGYRAGADYGTSRVQQSLENCSWEESVDEGEQPRTTSSSSYGQDTQKRDSFLQSIDNRIASEPVDPTGTCGYNSTPETFRSGCIMRDQMLGVKPHLSHVSLTREGKHRGQQTHLRKTGVPTWSAEEDASLAELVSRKGFKWALISSQLTGAFGIPRTGKQCRERWFNHVNPEVKKGDWSAEEDAMILMLQNELGNRWATIAKKLRGRTENAVKNRFISLSNARLGYGRPKRDGSSADCFSNRRTGSGKSSGITGMPNLCQSVCSAGTTKKDSSESGNHFVMSVATKVFEFSDVAVDSGVSRPRQCTGTSPSCGHPSAGEGDPSHLKNTDVVGREQPIQRNNNESGKAAEQTAFSGVKTGTLSVSQDAVPVGRLVVASVGPQHIRRSFPTDETLPKFAAKEHNNQQLNDEREHLEQSNSTSEGSFLASAHEHADIARSDPDEDTLEPHQKRRRKRCAIAYQGEERGDSNGLDSIADRAEQAGNFQAMRKANTDNGKVDYLEPHRYEKLSPCEQVIQPSLRPACDHRGAPQNSVESGEQSPDAQRQLCNQGCRTSNRTVHSSVYSNEVESNELRGVFRLAEQSLPSQSGDPAWSTAGFQLSILPQKVEVHSRNKCDGQNVMYRCSPGSLPTTHQQTVFHYDRDSSRFPCAAKPAAASGAQGTIEENDGLVKEGPSMIVTGSSVEVVHCCSVSLRRRDRSLPSAQLWTSQETESDTNPSPNQQHESCHQYCKRHAAWCGKTDQFSKLTSSHQENSSGKDACLVSVSPTVTLDDLQKQSRGTVLSAKEEIGKPETWSHVVDNTYSKTDHQRASLCAENSSGCAEGSTELVRFSGGSVKSGSSMSVDCGNGNPDDCQDCKAEEIWRGEQRYAERGHSVESRGAGSVGRSTDLTITDSGSMPLCASPIGRPPADNDTLFLSDARCNVVAQLNHQDNSRISRLASCEEEFLACGGERLINASGGFKPDGGCLYRMQQAGACNTKLHRPVHSCSTIDSEQLEDLPSVEKAVGDRSFSSKRKGDIPPFAEWKKNDELRELYRGVSEAVSHGQPGDWNGSWPGISGRAHQTSSCFPDRVNASDRRELNSWRLHVSAAAELGSSHIWNSQSYASASVSRDKQREPPKNGLTGCDVPEYLGTSQSAGLPAANAHERGNFYGHDRCRPREGERVRWVGLQRNRKPEASVSSGASNSATTARPKDSTEPDEGNSEGVSTRRKDSGSTAATISRAVSLGMVTPSAACENSSSLTDTSPPLSHRPSFSFTHCCEETLSRCNSSNYLCPPATCHTSDDGRSLGPSREAQALRSLSLASGYGYPGIPAEATSFWQGSSLEHSIMEPQMVPSDDELRLWVHPRDAANWSQSTLKPVAVVSGTDAGDDQHKTPENLTPESGQAHRRDGHDMQRVQRCDDEGECPPTTVELTFPHSHSSDEMQDLPSKVQGNFLLRRELSDSLQHETAESVAGYGWMRIRNAGDIPNSKVPCAWEQCMPASERERGVNDHMSSEASRMSKAASSSFVPSSCTDAPVVRVGEDTTKSVCEEQQLCEGGNRGSLSPEATGFESLGPPLQLLLVDGYTPFEPVVEKVSQTMEQTLFPVPGQETDTRDEDGRYNCECLQNRQPPLHSGGLM
What is the function of this protein?
Master transcription factor that controls the differentiation of acute-stage tachyzoite parasites into chronic-stage bradyzoites, which form intracellular cysts resistant to immune clearance and existing therapies (PubMed:31955846).  Sufficient to drive differentiation into bradyzoite stage (PubMed:31955846).  Following translation in response to stress conditions, binds to the promoter of many chronic stage-specific genes and promotes their expression, thereby driving differentiation into bradyzoites (PubMed:31955846).
What are the official names of this protein?
Bradyzoite-formation deficient protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1281_GEOSL
Sequence: MSHHIVEVRDLCHCYPDGTEALRGITFRIHHGESVAVVGANGAGKSTLLLHLNGYLAPTRGDVRIGDTPVVRTTLPEVRRTVGMVFQDPDDQLFMPTVFDDVAFGPLNLGLPPAEVERRVADALEQVGVAHLHNKPPYRLSGGEKRRVAIATVLSMSPDILVLDEPTTGLDPYARRQIMGLLRDFKHTKIITSHDLDMVMELCERTIVLREGRVAADGPTRDIFGNDELLATCRLERPLSMQGCPVCGR
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein GSU1281.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NODI_PARXL
Sequence: MPEAAIEFDKVKKSYGEKTVVDGLSFHVAPGECFGLLGPNGAGKTTTLRMLLGIAAPDAGTIRLCGEPIPRRARVARARVGVVPQFDNLDPDFTVRENLLVFGRYFGMSAAQCRAMVPPLLEFARLESKADARVSELSGGMKRRLTLARALVNDPDVLIMDEPTTGLDPQARHLIWERLRSLLARGKTILLTTHFMEEAERLCHRLCVIEEGRKIAEGAPSALIASEIGCDVIEIFGPDPVALRDELAPLVERTEISGETLFCYVIDAQPVHARLKQRADLRYLHRPANLEDVFLRLTGREMQD
What is the function of this protein?
Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction.  Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide.  This subunit is responsible for energy coupling to the transport system.
What are the official names of this protein?
Nod factor export ATP-binding protein I, Nodulation ATP-binding protein I.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipooligosaccharide exporter (TC 3.A.1.102) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NSRR_ECOLU
Sequence: MQLTSFTDYGLRALIYMASLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGYVTAVRGKNGGIRLGKPASAIRIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLTELDNYTLADLVEENQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: ORFD_ELHVK
Sequence: MAIPEAVTWDNLGSLMNNTQLNYFIPSHKNSIQYVCSDDKSRFSFVQCYLRILTLSIARFNEKSFDCSNQTIQNIYNLTMPGFFVQAPIPFCYDQNVANTKNCTLMLTSNDVMYWTYRQAVLNQPTFNNCMKPWKYIKFLSEKITNVNLTASQNIANSTMNFINRYINSSISMEKFLLTTIYNMAQPLGPRCSVEGLFSLSHYANKRLTERKN
What are the official names of this protein?
Protein ORF D.
Protein: RS21A_YEAST
Sequence: MENDKGQLVELYVPRKCSATNRIIKADDHASVQINVAKVDEEGRAIPGEYVTYALSGYVRSRGESDDSLNRLAQNDGLLKNVWSYSR
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102).  eS21 is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.  Has a physiological role leading to 18S rRNA stability (PubMed:14627813).
What are the official names of this protein?
40S ribosomal protein S21-A, S26, Small ribosomal subunit protein eS21-A, YS25.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS21 family.
Protein: SYP_SYNY3
Sequence: MRLSQMLFVTLRDDPADAEIPSHKLLVRAGFIRRLGSGLYAYLPLIWRVLEKVKRIVQEEMNRTGAQECLLPQLQPSELWKMSGRWDTYTESEGIMFALRDRLERELGLGPTHEEVITAIAKEMIRSYRQLPVNLYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFHSDEASLKATYGAMDQAYRNIFSRCGLDFRPVDADSGAIGGSGSQEFMVLADAGEDEILYTEDGLYSANVEKAVSLAPDAKPSPFSGYKKQSAPNTATIAKMCQCLDCDASNVVKNVLYQAVYNSGKAVLVLVSIRGDQEVNEVKLTNELTKLAPHYESTNILSLTVPDEKEQQKWAAKPLPLGYISPGISDDYIATNKQVADKFLRLVDQTAVDLTNFATGADAVDYHVTGANWSTDFTLPKLVVDVRKALAGDRPVHDPTGELKTARGIEVGHIFQLGTKYSQAMGATFTNEQGEEKPLVMGCYGIGVSRLAQAAVEQSYDKDGIIWPTAIAPYEVVIVVPNVGDEEQMQVAEQIYTEFQAAEVDVLLDDRNERAGVKFKDSELIGIPYRVVTGKSLKQGQLEVVKRADKSVQNLAIAAVVPTLTAWIKAEKKTS
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TALDO_DICDI
Sequence: MSNALEELKKYTTVVADTADFDVLSKYGSQDSTTNPSLVFQAASDPKYKSLIDDAIKYVNAKSGLSEKEKLSLAIDKLFVNFGVEILKIVPGRVSTEVDARLSYDIDANVKKGRELIALYKEAGIDKERVLIKLASTWEGIEAAKILEKEGIHCNLTLLFSLIQAAACAEAQVTLISPFVGRITDFYKSKQGVAGFEASKDPGVISVQQIYSYFKKHGYKTSVMGASFRNKEQTIELAGCDLLTISPNLLEELKNADASLVTKKLDSTKLPSDIPNKLDVSHSNFLWELNDNEMAYFKTGEGIRKFAEDLVKLENQIKKLL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCNA_THEPD
Sequence: MVKFVFPDAREWKYIIESLATIVDEANFVASPEGLKLRALDPGRIAMVDLFIPSNLFEEYSVDQETKISAVLDDIDKVLKRAKSDDKISFEVSQGRLIITLSGRAERRFKFPLIDIAGQELPSPKLNFTVAAKMLSDTFRDALKDASLVSESVKLKAEDESLWLLARSDKGEIESRFSIETGSLVEIDVKEAAEASYGIDFLDKIVSKAYRISDILGLRFATNMPLEMTFDIAGGGTLKYLLAPRME
What is the function of this protein?
Sliding clamp subunit that acts as a moving platform for DNA processing.  Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
What are the official names of this protein?
DNA polymerase sliding clamp, Proliferating cell nuclear antigen homolog, PCNA.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
Protein: END4_BACFN
Sequence: MKYIGAHVSASGGVEFAPVNAHEIGANAFALFTKNQRQWVSKPLTEDSIRLFKENCEKFGFAPEYILPHDSYLINLGHPEEEGLTKSRAAFLDEMQRCEQLGLKLLNFHPGSHLNKISVEECLDRIAESINLALEKTKGVTAVIENTAGQGSNLGNEFWQLKYIIDRVEDKSRVGVCLDTCHTFTAGYDFLNDYDDVFGEFGEVVGFEYLRGMHLNDSKKELGSRVDRHDSIGKGLIGFAFFEKLMKDPRFDNMPLILETIDETLWPEEIAWLREQTQ
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: RL5_STRTD
Sequence: MANRLKEKYTNEVIPALTEKFNYSSVMAVPKVDKIVINMGVGEAVNNAKTLEKAAAELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLDKLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEINFDDVDKVRGMDIVIVTTANTDEEGRELLKGLGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RF1_LISMF
Sequence: MYDRLQAVEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQINETKELLGEKLDDEMREMAKEEFAELQKEKADLEERLKLLLVPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKEIIAMMNGNDAFSRMKYENGAHRVQRVPETESGGRIHTSTATVAILPEAEEVEIELHDKDIRTDTFASTGAGGQSVNTTMSAVRLTHIPTGIVVSMQDERSQLKNKDKAMKVLRARVYDKFEREAREEYDANRKSAVGTGDRSERIRTYNYPQNRVTDHRIGLTIQKLDQIMEGKLDEIIDALILEDQTSKLEHLNDAN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCR_METS5
Sequence: MRRTLKAAILGATGLVGIEYVRMLADHPYIKPTYLAGKGSVGKPYGEIVRWQTVGNVPKEVANQEVKPTDPKLMDDVDIIFSPLPQGAAGPVEEQFAKLGFNVISNSPDHRFDMDVPMIIPEVNPHTVTLIDEQRKRRDWKGFIVTTPLCTAQGAAIPLTPIYQNFKMSGVMITTMQSLSGAGYPGIASLDIVDNALPLGDGYDAKTVKEITRILSEVKRNVQEPGVNEITLDATTHRIATIHGHYEVAYVTFKEDTDVRKVMESMESFKGEPQDLKLPTAPEKPIIVTTQDARPQVFFDRWAGNPPGMSVVVGRLKQVNPRTIRFVSLIHNTVRGAAGGGVLTAELLVEKGYIDKR
What is the function of this protein?
Catalyzes the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutyrate cycles.
What are the official names of this protein?
Malonyl CoA reductase (NADP), NADP-dependent malonyl CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the aspartate-semialdehyde dehydrogenase family.
Protein: CRCB_MAGSA
Sequence: MLTYALVALGSAIGGTLRYWLSMVIAEASAGTFPWATLVINVAGSAAIGLFATLTSVDGRVFVPSEWRTFFMVGICGGFTTFSSFSLQTLALAQDGDWLAAGLNVVGSVALCLLAVWLGHVAATIINR
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CH60_SHEON
Sequence: MAAKEVVFGNDARVKMLAGVNILANAVKVTLGPKGRNVVLDKSFGSPLITKDGVSVAKEIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVTEGLKAVAAGMNPMDLKRGIDKAVIAAVAELKNLSQDCADSKAIAQVGTISANSDESIGQIIATAMEKVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELDHPFVLLVDKKISNIRELLPILEGLAKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVAILTGGTVIAEEIGLELEKATLEDLGTAKRVVITKDNTTIIDGNGEQAQIEARVSQIKQQIEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALIRVASKIADVEVANEDQKHGVVIALRAMEAPLRQIATNAGEEASVVANNVKNGSGNYGYNAGNDTYGDMLEMGILDPTKVTRSALQFAASIAGLMITTEAMVAELPKADAPDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPA_SULIL
Sequence: MYKHPWLPNLDLIDEMLKEIGVNSLDELFNDIPAEIKINRLLNVAKGKPLSEYEIEKEINEKVKKNVELQAPPFIGAGICPHYIPNVVKFIIGRSEFYTSYTPYQPEISQGLLQALFEYQSLMAELLDMDVVNASMYDWGSALAEAVLMANRINGKKTVLVPENANPFHKEVVRTWIGGKGIKIEEVKYDKNSGELDLEDLEKKSNIDDISAIYIQQPNFFGIFESNIEHVIDVAKHKRALSIVGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGVFAVRWDMSLVRQMPGRIVGITKDTNGKMGFTLILQTREQFIKREKATSNITTNEALLAIANAVYLSLLGKEGMRELAEEIYFRSHYAAKKLTEIDNVSMPFRSDFFEEFAIRFPIEYDKISNKLKERKLQGGLKLSDYTSLFCVTEVHDKKSIDLLVSTIQEMINGVETS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: IHFB_SHESH
Sequence: MTKSELIEKLATRQSQMSAKEVESAIKEMLEQMAQTLEGGDRIEIRGFGSFSLHFRAPRTGRNPKTGTSVDLDGKYVPHFKPGKELRERVDAINA
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: THIE_BORPE
Sequence: MKTLRFPAGLYGITPEWDDTDRLLAAVRAAAAGGMTALQLRRKLADERLRAAQARALAPLCRELGVVFLVNDHWKLALDVGADGAHLGRDDADPATVRAQAGAGLLLGVSCYNDLRRADALLAAGADYVAFGTVFASPTKPEAVHAPLQTLTEARARVLACPAPRPAVVAIGGITPANVSQVAQAGADSAAVISGLFEAPDIQAAARACAAAFSVNP
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.