PharMolix/UniProtQA huggingface dataset:
Protein: SYD_SHEDO
Sequence: MRSHYCGDINRSHLGQEVTLVGWVNRSRDLGGVVFLDLRDREGLVQVVYDPDLKDVFDVASSLRGEFCVQVTGLVRARPDSQINSQMKTGEIEVLGKGLTIINASAPLPLSMDNHQNNSEEQRLKYRYLDLRRPEMAERLIFRAKVTSAVRRFLDSNGFLDIETPILTKATPEGARDYLVPSRTYKGQFFALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIETSFMTSEEVMVKTEEMMRGLFLELLNVDLGEFPRMTYNEAMRRFGSDKPDLRNPLELVDVADLLKEVEFAVFNGPANDEEGRVAALRIPNGATLSRKQIDDYTKFVGIYGAKGLAWMKINDLAAGMEGIQSPVLKFLTESIVNDIISRTGAQTGDIILFGADKANVVAEAMGALRLKAGEDFELLEGQWRPLWVIDFPMFEKINGGFHAVHHPFTAPRGVTAAELEANPANRVSDAYDMVLNGCELGGGSVRIHNAEMQSAVFRILGIEEEEAKEKFGFLLEALRYGTPPHAGLAFGLDRIIMLMTGATSIRDVMAFPKTTTAACPLTNAPGFANPAQLTELGIKVVEKVKVADGE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MK07_HUMAN
Sequence: MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
What is the function of this protein?
Plays a role in various cellular processes such as proliferation, differentiation and cell survival.  The upstream activator of MAPK7 is the MAPK kinase MAP2K5.  Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C.  EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway.  May have a role in muscle cell differentiation.  May be important for endothelial function and maintenance of blood vessel integrity.  MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.  Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression.  Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
What are the official names of this protein?
Mitogen-activated protein kinase 7, MAP kinase 7, MAPK 7, Big MAP kinase 1, BMK-1, Extracellular signal-regulated kinase 5, ERK-5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.
Protein: NADD_SYMTH
Sequence: MARVAVLGGTFDPIHLGHLAAAQGVLHLTGVERVIFLPNRQPPHKQGQPVTPAEHRAAMVRLAIADNPAFGFSDLELRRPGPSYTIETVRALAAEHPDWEPAFIIGLDSLLAIRTWREWETLMQSVDFFAVTRPGHDLAAARRLLAELGPRLSGRVRLLEIPGVAVASADLRRLAAAGYPLRYLVPDPVARYIAEHRLYLRGESHGDG
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: MATP_ECO81
Sequence: MKYQQLENLESGWKWKYLVKKHREGELITRYIEASAAQEAVDELLSLENEPVLVNGWIDKHMNPELVNRMKQTIRARRKRHFNAEHQHTRKKSIDLEFIVWQRLAGLAQRRGKTLSETIVQLIEDAENKEKYANKMSSLKQDLQALLGKE
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIO_BUCBP
Sequence: MTNCIVELTDGIFKQYILESKKAVLVDFWAEWCNPCKILAPILEDIAKEYEHKLIVTKINIDKNPNTAPKYSIRGIPALLLFKNSELVGTKVGALSKVQLKDFLNLYLK
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: MYNN_DANRE
Sequence: MPHITHSEFLLEQLKRQRERSFLCDCTVSIGQAQYRAHHNVLAAFSEYFSTQSVDAGREDPTITLDPESVSSAIFEKLLTYIYTGDLNMDREEIESVQKAASYLGMPEVVARCTLSQDNIKNVGSPMRQAEYEDPRSPLSPDDYEPLEPISEVEERELLREDRAGDDLVSMDEAQSSSEQTPQRVGKRGRKPKTRLYEDEFEVETISAQRGRGRGRGRPRGRPRVRPLSSDSTDQSPAHQAMSPNGSSTSRGSGRPRGRPRVRPLSTANEDPRNVEDDPAANKDQEVEKGNEEQKKETGEKDDGKNDTDNPEEVTAFKRGRGRPRIKPVSTEDQTTNSENVTTNAEDGSEPAKTKDSEGTGRKRGRPRSKPVSSEDPESVISVEISGEEAGEETSQDAEKHTEEGTEDSESNPGNSVRISKRKRILSRKLKESQAGDEEEEEEEEMDDEFENDNEDWAGEEEVKPVQDKHRPICNICGNLFSEMSSLRRHMRIHKGLKPYQCTLCTRSFRQGNQLKTHMRIHTGEKPFTCTSCDSRFAQKCQLVYHCRMHHGEEKPYKCEFCGAAFATSSNLKIHIRKHSGEKPYECGECGKRFTQASTLMYHKRRHTGEKPYICDTCGMAFAVSSSLIAHNRKHTGVTPYICLDCGKPCLTAGELRKHMDVHNDIYSLKKHSILKHNVVPELETTQTSKTDPTQCPLNIPIDHQGLIARVRSALVDSQDHEIQMEPPLPILPPETSLTIQQSAEPQMIIQHADGSEPSMIFQHAEASEAPMLIQHGEPGEQVSYVVEQYEIPATAEMEHTQIVIVQTID
What are the official names of this protein?
Myoneurin.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NXT1_CAEEL
Sequence: MSMKTTQEINKEDEELCNESKKFMDVYYDVMDRKREKIGFLYTQVSNAVWNGNPINGYDSICEFMKALPSTQHDIQSLDAQRLPEGVTGDMSGGMLLNVAGAVTVDGDSKRAFTQTLLLGVEDGKYKVKSDRFRYVD
What is the function of this protein?
Stimulator of protein export for NES-containing proteins.  Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).
What are the official names of this protein?
NTF2-related export protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPG_SYNSC
Sequence: MTALARRYDTQIHRRVTRTVMVGDVPVGSEHPIVVQSMINEDTLDIEAAVAGIIRLAEAGSEIVRVTTPSMAHAKAMGQIRKELRQRGCSVPLVADVHHNGVKIALEVAQHVDKVRINPGLFIFDKPDPNRQEFSPEEFAAIGQRIRETFEPLVTLLRDQNKALRIGVNHGSLAERMLFTYGDTPEGMVESAMEFVRICHELDFHNILISMKASRAPVMLAAYRLMADTMDKEGFNYPLHLGVTEAGDGDYGRIKSTAGIATLLADGLGDTLRVSLTEAPEKEIPVCYSILQSLGLRKTMVEYVACPSCGRTLFNLEEVLHKVRNATSHLTGLDIAVMGCIVNGPGEMADADYGYVGKTPGVISLYRGRDEIRKVPEAEGVEALIQLIKEDGRWVEPA
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: YMGD_ECOL6
Sequence: MKKFALLAGLFVFAPMTWAQDYNIKNGLPSETYITCAEANEMAKTDSAQVAEIVAVMGNASVASRDLKIEQSPELSAKVVEKLNQVCAKDPQMLLITAIDDTMRAIGKK
What are the official names of this protein?
Uncharacterized protein YmgD.
Protein: RL11A_SCHPO
Sequence: MAEKAQNPMKELRISKLVLNISLGESGDRLTRAAKVLEQLSGQTPVFSKARYTIRRFGIRRNEKIACHVTVRGPKAEEILERGLKVKEYELKKRNFSATGNFGFGIQEHIDLGIKYDPSIGIYGMDFYVVMDRPGMRVARRKAQRGRVGYTHKINAEDTINWFKQKYDAVVLGK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L11-A.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CARB_PEDPA
Sequence: MPKREDINKILVLGSGPIIIGQAAEFDYSGTQACLSLKELGYQTVLINSNPATIMTDTDIADKVYIEPLTLQFVSQILRKELPDAILPTLGGQQGLNMAMELSEAGILDELGIELLGTKLDAIDQAEDRERFRALMNDLNEPVPDSGIATTVEEAVSFADQSGYPVIVRPAFTMGGTGGGIAQDEAELRKITANGLTLSPVTQVLIEQSIAGLKEIEFEVMRDSVDNAIVVCNMENFDPVGIHTGDSIVYAPVQTLTDREVQMLRDASLSIIRALKIEGGCNVQLALDPAQDRYYVIEVNPRVSRSSALASKATGYPIAKVAAKIAVGLTLDEILNPVTGTTLAEFEPALDYVVCKIPRWPFDKFVRADRRLGTQMKATGEVMAVGRNVEEATQKAIRSLDIDINYIGDEELADLNEADLVDGIIHARDDRIFYLYEAIKRGYSVDKLADLTKINVYYLDKLLHIYEIEQELIATPFNADVLELAKKNGFSDEVIGKMWKTNEKEVRAYREQMGLSPVYKMIDTCAGEFESQTPYYYSTYELENESIVSNRKSIVVLGSGPIRIGQGVEFDYATVHSIQAIRQMGYEAIVVNNNPETVSTDFSMSDKLYFEPLTVEDVMNVIDLEKPEGVIVQFGGQTAINLAEPLAERGIKIFGTTVENVNRAEDRDEFNKLIQANGIRQPQGRTATTTSGAIEAAESIGYPVLVRPSYVLGGRAMEIVHAKEELENYMKNAVKVSHNHPVLVDQYLVGKECEVDVISDGENVVIPGIMEHIERSGVHSGDSMTVYPAQTLSQKVQDEIVKVSIKLAQSLECIGLMNIQFVVHNDEAYVIEVNPRASRTVPIMSKVTDLPMARLATRAILGESLVNQGLKPGLHPAGEIIHVKAPVFSFTKLDNVDSLLGPEMKSTGEVMGSDRTMAKALYKAFEGAKMHMPDHGKVLITVKDEDKGEAIDFARRFWELGYQLVATKGTAQTLAAHGLKVETVGKMTEENNIVDRIHDHRIQMVINTISDSTTSAADGIKIRSTALTYGVPLFTALDTVDAILQVLESQAFTTLHL
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: FLOWR_DROGR
Sequence: MSFAEKITGLLARPNQDPAGGPEAPWYLKYGSRVLGIVAAFFAILFGLWNVLSIIGLSVSCLVAGIIQMLAGFVVMALEAPCCFVCIEQVGSVADKVDAKPMYFRAGLYCAMAVPPIFMCFGLASLFGSGLIFATGAVYGMMALGKKASATDMRAAAQQSGYGGNATTSTTNDRAGIVNNAQPFSFTGAVGTDSNV
What is the function of this protein?
A calcium channel that regulates synaptic endocytosis and hence couples exo- with endocytosis.  Required in the nervous system and necessary in photoreceptor cells (By similarity).
What are the official names of this protein?
Calcium channel flower.
What is the protein family that this protein belongs to?
Belongs to the calcium channel flower family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Upon fusion of the synaptic vesicle with the presynaptic membrane, protein is present in the periactive zones, where endocytosis is known to occur.
Protein: RPOZ_RICRS
Sequence: MARITAEDCNKIIPDRFRLVVLATRYAKLLNYKVETNHIKKEKLDKPPVIALRRIAAGKVSVAQLEQDLINSLRTRTMIEPLVNQDESEAVEEKFEYLPEVYIGEDYSDLDDQIFIDEHGEDYETDK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RS15_STRPC
Sequence: MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNSHIKEHKKDHATYRGLMKKIGHRRNLLAYLRRTDVNRYRELIQSLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: CYNS_BOTFB
Sequence: MADQTKIATLDSTLIDRLPTSSKTLFEAKATKALTFESIANELGRSEVAVAALFYGQSQASAADIEKLSQILDVPQSKLEAELGGFPDRGRAGPMPPVEPLIYRLYEIVQNYGYAYKAVMNEKFGDGIMSAISFSTKVEKETDEQGNNWAVITLRGKWLPFSRF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: RIMP_CALS4
Sequence: MSRIEEITKELVMPILEENNFELVDVEYKKEGKHWYLRVYIDKEGGITLDDCQLVSEYLSDRLDEVDPIDHSYILEVSSPGLDRPLKTPRDFKRNLGKEVEVSLYQPIDKRKKFTGELLEFTGDKIILLCEGEKREFEMKNVRLVKPVIKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2C52_ORYSJ
Sequence: MVYDGAVKDQESSANPASASAALSEASAAASEVTAAAAAGAGAGAAEEGAAVSGRPPRPPHDKRLGVRHPLKHRRFRAGGKVMVEPGDPPSAQEVADEEASEVEQEAAPVEREPPQEEGGDVEVSSAPAEMEVVEGDAMEVSPEPAVAVGESELEGRPGEEEEVSSPVVSQGERKQETAAAAPVPAVEEKKHKDQENKHKEREREKERERVDEVGYMSGGWKSEDGFLSCGYSSFRGKRASMEDFYDIKSSKIDDKQISLFGIFDGHGGSRAAEYLKEHLFENLMKHPEFMTNTKLAISETYKKTDSEFLDSESHTHRDDGSTASTAVLVGNHLYVANVGDSRAVISKAGKAIALSEDHKPNRSDERKRIESAGGVVMWAGTWRVGGVLAMSRAFGNRLLKQFVVADPEIQEQEIDDELEFLILASDGLWDVVPNEDAVSLVKIEEEPEAAARKLTETAFSRGSGDNITCIVVKFQHDKMDGDSSPTSDKS
What are the official names of this protein?
Probable protein phosphatase 2C 52, OsPP2C52.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: RIMM_NOSP7
Sequence: MKHEEANKEIGGRGAEGQRSKRVGGNSKIQNIQSPAPNPQPIVPNTQSPVPNLDNWLEIGKIVSPQGLSGELKVYPVSDFPERFEVPGKRWLLHLDGTEPQPIQLLTGRYISNKNLYVIKLAGVENCDQAEALRGCKLMVPASDRPQLAEDEYHVLDLIGLEVFMQASGELVGTVVDIIPAGNDLLEVKLHPSFTTDKKQKTVLIPFVEAIAPVVDLKSNRIEITPPPGLLEINN
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDM1_MOUSE
Sequence: MAELISFVVPTQSDKVLLVWDLSTGPPAEALSHSLFTVFSQFGLLYSVRVFPNAAVARPGFYAIIKFYSSRDAQRAQKACDGKPLFQTSPVKVRLGTRHKALQHQAFALNSSRCQELANYYFGFSGWSKRIIKLQELSGLEDAALAVPMQKGSPQFLCAVEVVLPPYGCRSPGVGISEEPLRQLEEGQSSFLMKRKTAQKLAFQAAVSDAFQKLTIVVLESGRIAVEYRPTAEDLDARSEEELQNLIQVSCSSWSQSSQREEECLSDFSLEEEDLKLCDPH
What is the function of this protein?
May confer resistance to the antitumor agent cisplatin.  Binds to DNA and RNA (By similarity).
What are the official names of this protein?
RAD52 motif-containing protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, nucleolus. Nucleus, Cajal body. Nucleus, PML body. Note=After treatment with proteasomal inhibitors and mild heat-shock stress is relocalized to the nucleolus as dot-like or irregular subnuclear structures. Colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress. Relocalized in nucleolar caps during transcriptional arrest (By similarity).
Protein: ILVC_STRZP
Sequence: MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDVIIGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGNAKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAELRKAMPFVGKNDDDAFKIYN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: EMC5B_XENLA
Sequence: MASSIWKGLVGIGLFALAHAAFSAAQHRSYMRLTEKEDETLPIDIVLQTLLAFIVACYGIVHIAGEFKDMDATSELRNKTFDTLRNHPSFYVFNHRGRVMFQPPESEDCHRNQAPFSSNSSLKLSKLEAMHR
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity).  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.  May be involved in Mg(2+) transport (By similarity).
What are the official names of this protein?
ER membrane protein complex subunit 5-B, Membrane magnesium transporter 1-B.
What is the protein family that this protein belongs to?
Belongs to the membrane magnesium transporter (TC 1.A.67) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: TILS_ENTFA
Sequence: MFWQFYKRGKEQGFWQPHQTIVVAVSGGVDSMALLTLMEQVAEKEQLQLVVAHVNHQLREASAQEAQYLATYCQQRELTYYETRWEDPEKQRNLEAKARTFRYEFFKEVMEIEGAAVLMTAHHLDDQAETILMKLIRGTNFSHSAGIKERRPFATGELIRPLLIYPKEELYQFAQRQAFVYFEDETNQTNEYLRNRLRNQVLPLLKQENPQFLDQIASFSNEQRFAQEFIQEQIEPQLSEAVEPTKQGWRIPLKRLLKETPAYQHFFLTAFFQKTLVPLGVSLNQRQMTQILKVLNDERQPQGSVMLEQQWQLAKSYDWLCLEQKQAALREEVTHLLVPGAGIYLSETEWLGLIATDKPFPLPEEINQWTGQLLAIPLTTATPLTVRHRQSGDRITLKPGFTKKLSRVFIDQKVPNEARESAWVITDEQEEIIWVPKFANSYLSIPLETDKIHYRLLFKTKE
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRRK1_HUMAN
Sequence: MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRAAYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTDDNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADPESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTGRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
What is the function of this protein?
Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.
What are the official names of this protein?
Leucine-rich repeat serine/threonine-protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_DELAS
Sequence: MARVCEVTGKKPMVGNNVSHANNKTKRRFLPNLQYRRFWVESENRWVRLRVSSAALRLIDKNGIDSVLADLRARGQA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: BHE23_MOUSE
Sequence: MAELKSLSGDSYLALSHSYTATGHAYAAARGPETTRGFGASGPGGDLPAAPASRVPAATVESSGEQSGDEDEAFERRRRRRGSGVAVDARRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQGLAAPVAAAPLTPFGQAAIYPFSAGTALGPCPDKCATFSGSPSALCKHCGEKP
What is the function of this protein?
May function as transcriptional repressor.  May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types.  May be important for rod bipolar cell maturation.
What are the official names of this protein?
Class E basic helix-loop-helix protein 23, bHLHe23, Class B basic helix-loop-helix protein 4, bHLHb4.
What are the subcellular locations of this protein?
Nucleus.