PharMolix/UniProtQA huggingface dataset:
Protein: KAD_CORA7
Sequence: MRYVLLGPPGAGKGTQAALLSEKLGVPHISTGDLFRANIGEGTPLGLEAKSYIDAGKLVPTDVTARMVEDRLNQDDAKDGFLLDGFPRTVQQADILEKLLSDKDLKLDGVLNFEVSEDVVVERMLARGRADDTEETIRTRLGVYREETFPLIEHYGDAIISIKAEGTVEEINERTLQAMGK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOH_ECO57
Sequence: MSWISPELIEILLTILKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLAFAIVPVSPGWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNMTDIVNSQAHVWNVIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTISALMVTLFFGGWQGPLLPPFIWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKICLPLTLINLLVTAAVILWQAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H, NUO8.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL34_SYNWW
Sequence: MKRTFQPKNRQRKREHGFRARMASAGGRKVLANRRKKGRKSISA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: FTSH9_ARATH
Sequence: MTSIELLSPLIHDKFRFSTCCSTSSLLYLHASSFFRDRSFGFRQNPNRFVSNSSIQLPQSVPGSINQERFNLWQGFSRKKSTSSSRTIVNCQEGDQKASSSEGEGKTNKDKGRKQGKNELWWSKGKKWQWKPIIQAQEIGVMLLQLGIVMFVVRLLRPGIPLPGSEPRTQTTFMSVPYSDFLSKVNNDEVQKVEVDGFHVLFKLKDDGNLQESETSSSSIKLSESSETMLRSVAPTKRVVYSTTRPRDIKTPYEKMLENNVEFGSPDKRSGGFFNSGLIVLFYIAVLAGLLHRFPVNFSQSTTGQLRTRKSGGPGGGKVSGDGETITFADVAGVDEAKEELEEIVEFLKNPDRYVRLGARPPRGVLLVGLPGTGKTLLAKAVAGESDVPFISCSASEFVELYVGMGASRVRDLFARAKKEAPSIIFIDEIDAVAKSRDGKFRMVSNDEREQTLNQLLTEMDGFDSSSAVIVLGATNRADVLDPALRRPGRFDRVVTVESPDKVGRESILKVHVSKKELPLGDDVNLASIASMTTGFTGADLANLVNEAALLAGRKSKMTVDKIDFIHAVERSIAGIEKKTARLKGSEKAVVARHEAGHAVVGTAVASLLSGQSRVEKLSILPRSGGALGFTYIPPTHEDRYLLFIDELHGRLVTLLGGRAAEEVVYSGRISTGALDDIRRATDMAYKAVAEYGLNEKIGPVSVATLSAGGIDDSGGSPWGRDQGHLVDLVQREVTNLLQSALDVALTVVRANPDVLEGLGAQLEDEEKVEGEELQKWLNRVVPSEELAVFIKGKQTALLPAQASSS
What is the function of this protein?
Probable ATP-dependent zinc metallopeptidase.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FTSH 9, chloroplastic, AtFTSH9.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein; Stromal side.
Protein: PA2GE_MOUSE
Sequence: MKPPIALACLCLLVPLAGGNLVQFGVMIERMTGKPALQYNDYGCYCGVGGSHWPVDETDWCCHAHDCCYGRLEKLGCDPKLEKYLFSITRDNIFCAGRTACQRHTCECDKRAALCFRHNLNTYNRKYAHYPNKLCTGPTPPC
What is the function of this protein?
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:11922621, PubMed:10531313).  Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), releasing various unsaturated fatty acids including oleoate, linoleoate, arachidonate, docosahexaenoate and lysophosphatidylethanolamines in preference to lysophosphatidylcholines (By similarity).  In response to high-fat diet, hydrolyzes minor lipoprotein phospholipids including phosphatidylserines, phosphatidylinositols and phosphatidylglycerols, altering lipoprotein composition and fat storage in adipose tissue and liver (PubMed:24910243).  May act in an autocrine and paracrine manner (By similarity).  Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance.  Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (By similarity).  Acts as a hair follicle phospholipase A2.  Selectively releases lysophosphatidylethanolamines (LPE) and various unsaturated fatty acids in skin to regulate hair follicle homeostasis (PubMed:27226633).  May regulate the inflammatory response by releasing arachidonate, a precursor of prostaglandins and leukotrienes.  Upon allergen exposure, may participate in allergic inflammatory response by enhancing leukotriene C4 synthesis and degranulation in mast cells (PubMed:11922621).
What are the official names of this protein?
Group IIE secretory phospholipase A2, GIIE sPLA2, sPLA2-IIE, Phosphatidylcholine 2-acylhydrolase 2E.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=Through binding to heparan sulfate proteoglycan, may be localized to cytoplasmic compartments enriched in anionic phospholipids.
Protein: HLDE_SHEB5
Sequence: MKVSLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVKINQVEDRPGGAANVALNIATLGGQVQLAGLVGQDDTAHALTLGVQTLGVEPQWLTIADKPTITKLRVLSRNQQLIRLDFEEAFDKADSVRLLKQSEALLDSVDVVVLSDYAKGAIDQPRDFIALARAKGVMVLVDPKGSDFGRYQGASLITPNMSEFEAVVGTVTSEADLLEKARGLLKQHHFDAILVTRSEKGMTLVTTNAPELHIPTVAREVYDVTGAGDTVISALATSLAAGADLPQACAIANTAAGVVVGKLGTSTVSRIELIEALALHHGESGFGVVSEDQLAYALEQAKLRGERVVMTNGCFDILHAGHVSYLKQAKALGDRLIVAVNDDASVKRLKGDGRPVNQVDRRMAVLAGLASVDWVVPFSEDTPQRIITRLLPNLLVKGGDYKLEDIAGGAEVIAAGGQVQVLGFEDGISTTAIIQNIMANQ
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: RS19_DEIRA
Sequence: MPRSLKKGPFVEDHLLKKVDAQNDKKDKRVIKTWSRRSTIVPEMIGHTIAVYNGKQHVPVFVNEQMIGHKLGEFSPTRTYRGHGADKNAKGSKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: GLYA1_PSESM
Sequence: MFSKQDQIQGYDDALLSAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVEQLAIERARQLFGADYANVQPHSGSQANAAVYLALLQAGDTVLGMSLAHGGHLTHGAKVSFSGKLYNAVQYGIDTTTGLIDYDEVERIAVECQPKMLIAGFSAYSKTLDFPRFRAIADKVGAYLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLILAKANEELEKKFNSAVFPGGQGGPLMHVIAAKAVCFKEAMEPGFKTYQQQVIDNAQAMAQVFITRGFDVVSGGTDNHLFLVSLIRQGLTGKEADAALGRAHITVNKNSVPNDPQSPFVTSGLRIGTPAVTTRGFKVTQCIELAGWICDILDNLGAADVEANVASQVAALCADFPVYR
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 1, SHMT 1, Serine methylase 1.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAUE_CUPNH
Sequence: MKAELLLPLLGLQALLGAGTYFQTVTGFGLGMIVMGVTSGLGLAPVATVAAVVSLVTLANSACALPGKLQHIDWRAVAAAAIGILPSVVVGVLVLEYLSSSAATLLQLLLGAVILYGGLSAALKPAPLAQRSGDGTFFVSGVFGGLLSGMFGVSGPPLIFQFYRQPMKPVEIRCALILVFTVTSTVRTLFSAWQGQLDAAVCVQAAIAVPVVVIATLLGRRFPPPFSPATTRRVAFGVLIGIGASLMLPAISAWVL
What is the function of this protein?
Could be a sulfite/organosulfonate exporter with a wide substrate range, including 3-sulfolactate and 3-sulfopyruvate.
What are the official names of this protein?
Probable sulfite/organosulfonate exporter TauE.
What is the protein family that this protein belongs to?
Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FSTL1_PONAB
Sequence: MWKRWLALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSRGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI
What is the function of this protein?
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity).  Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter.  Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner.  Also promotes survival of cardiac myocytes (By similarity).  Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity).
What are the official names of this protein?
Follistatin-related protein 1, Follistatin-like protein 1.
What are the subcellular locations of this protein?
Secreted.
Protein: RL9B_CANAL
Sequence: MKYIQTDQILDIPEGVTVDIKARVVKVTGPRGELTKDLKHIDVTFNKINNRAIKITVHNGDRKHVAALRTVKSLIANLITGVTKGYKYKMRFVYAHFPINVNIIKKDGQDYVEIRNFLGEKRVREVKIHEGVTMEISSTQKDELIVSGNSLEAVSQNAADIQQICRVRNKDIRKFLDGIYVSERGTIVEEI
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L9-B.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: BMNL1_BOMOR
Sequence: MNFKYIVAVSILIASAYARSEENDIQSLSQRDVLEEESLREIRGIGASILSAGKSALKGLAKGLAEHFANGKRTAEDHEVMKRLEAAIQSLSQRDVLEEESLREIRGIGASILSAGKSALKGLAKGLAEHFANGKRTAEEHEVMKRLEAVMRDLDSLDYPEEASEMETRSFNQEEIANLYTKKEKRILGPILGLVSNALGGLLG
What is the function of this protein?
Has antimicrobial activity, but no hemolytic activity.  Preference on killing Gram-negative non-enteric bacteria.
What are the official names of this protein?
Bombinin-like peptides 1.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CSM3_STRTR
Sequence: MTFAKIKFSAQIRLETGLHIGGSDAFAAIGAIDSPVIKDPITNIPIIPGSSLKGKMRTLLAKVYNEKVAEKPSDDSDILSRLFGNSKDKRFKMGRLIFRDAFLSNADELDSLGVRSYTEVKFENTIDRITAEANPRQIERAIRNSTFDFELIYEITDENENQVEEDFKVIRDGLKLLELDYLGGSGSRGYGKVAFEKLKATTVFGNYDVKTLNELLTAEV
What is the function of this protein?
This subunit has the target ssRNA endonuclease activity; it cleaves multiple sites in the target RNA at 6 nucleotide intervals.  The number of cleavage sites in the target RNA correlates with the number of Csm3 subunits in the Csm effector complex (PubMed:25458845).  In the Csm complex target RNA and ssDNA are cleaved simultaneously, although RNase activity (of Csm3) is much faster.  RNA cleavage by Csm3 is not required for ssDNase activity as Csm complex with inactive Csm3 still has ssDNase activity; however as the cleaved target RNA products dissociate away ssDNase activity decreases (PubMed:27105119).
What are the official names of this protein?
CRISPR system Cms endoribonuclease Csm3, Csm3 RNase, CRISPR type III A-associated RAMP protein Csm3.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Csm3 family.
Protein: ISPF_EHRCR
Sequence: MNQHPNKPIFKVGIGYDVHKFDNTCYNDANTFITICGIKINYHKKIIAHSDGDVGLHALTDAILGAVGCGSIGQHFPNTDNTWKNIKSDYFLIEAQKKAQEKGYSISNADITIICEQPKIMPHALEMQEYIANLICIDPSCINVKATTTEKLGFLGRKEGIAAQAIVLCCLQN
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: YB029_YEAST
Sequence: MSFIPIVCGMKSFDSSYDTVPGHQNLYCPNCHNYSVGPIKRKEFFTIWFIPLVPVFWGKQLHCPICNWRQDFKNDEQLNKVIQEQQNLRQKQPN
What are the official names of this protein?
UPF0768 protein YBL029C-A.
What is the protein family that this protein belongs to?
Belongs to the UPF0768 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Note=Cell periphery.
Protein: PP4C_CANGA
Sequence: MLVDLDEILVSLKEGRHIPEETVYALCMDSQELLMNESNVARVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYVFLGDFVDRGFYSLESFLLLLVYKLRYPDRITLIRGNHETRQITKVYGFYDEVMRKYGNSNVWRYCCEVFDYLSLGAIINDSIFCVHGGLSPDITTLNEIRAIDRKQEVPHEGGMCDLLWSDPDEVDTWSMSPRGAGFLFGKGEVDEFLHVNNVDLIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIEDNLERKYTIFEAVQAQNGVGNTIIPTKKAQMDYFL
What is the function of this protein?
Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process.  Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 catalytic subunit, PP4C.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NGA4_ARATH
Sequence: MNISTMNLDQELAEIRASSSDHTNYFYSSERREHMFDKVLTPSDVGKLNRLVIPKQHAENFFPLEDNQNGTVLDFQDKNGKMWRFRYSYWNSSQSYVMTKGWSRFVKEKKLFAGDTVSFYRGYIPDDNAQPERRRKIMFIDWRPRAEINFVHNINNHNFVFGSPTYPTARFYPVTPEYSMPYRSFPPFYQNQFQEREYLGYGYGRVVNGNGVRYYAGSPLDQHHQWNLGRSEPLVYDSVPVFPAGRVPPSAPPQPSTTKKLRLFGVDVEESSSSGDTRGEMGVAGYSSSSPVVIRDDDQSFWRSPRGEMASSSSAMQLSDDEEYKRKGKSLEL
What is the function of this protein?
Regulates lateral organ growth.  Functionally redundant with NGA1, NGA2 and NGA3.
What are the official names of this protein?
B3 domain-containing transcription factor NGA4, Protein NGATHA 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUOD_BURO1
Sequence: MAEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAESKTFIQSVPYMDRLDYVSMMVNEHGYVLAIEKLLGIEVPERAQYIRVLFDEITRVLNHLMWIGAHALDVGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVYRDLPDAMPQYKASKIRNEKALAKMNEARSGSVLDFIDDFFTRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQMGLTGPMLRGSGIAWDLRKKQPYEVYDRMDFDVPVGVNGDCYDRYLVRVEEMRQSIRIAKQCIEWLRKNPGPVMTDNHKVAPPSRVGMKTNMEDLIHHFKLFTEGFHVPEGEAYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGFAHLASLDEMARGHMIADAVTIIGTQDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
Protein: RBNS5_HUMAN
Sequence: MASLDDPGEVREGFLCPLCLKDLQSFYQLHSHYEEEHSGEDRDVKGQIKSLVQKAKKAKDRLLKREGDDRAESGTQGYESFSYGGVDPYMWEPQELGAVRSHLSDFKKHRAARIDHYVVEVNKLIIRLEKLTAFDRTNTESAKIRAIEKSVVPWVNDQDVPFCPDCGNKFSIRNRRHHCRLCGSIMCKKCMELISLPLANKLTSASKESLSTHTSPSQSPNSVHGSRRGSISSMSSVSSVLDEKDDDRIRCCTHCKDTLLKREQQIDEKEHTPDIVKLYEKLRLCMEKVDQKAPEYIRMAASLNAGETTYSLEHASDLRVEVQKVYELIDALSKKILTLGLNQDPPPHPSNLRLQRMIRYSATLFVQEKLLGLMSLPTKEQFEELKKKRKEEMERKRAVERQAALESQRRLEERQSGLASRAANGEVASLRRGPAPLRKAEGWLPLSGGQGQSEDSDPLLQQIHNITSFIRQAKAAGRMDEVRTLQENLRQLQDEYDQQQTEKAIELSRRQAEEEDLQREQLQMLRERELEREREQFRVASLHTRTRSLDFREIGPFQLEPSREPRTHLAYALDLGSSPVPSSTAPKTPSLSSTQPTRVWSGPPAVGQERLPQSSMPQQHEGPSLNPFDEEDLSSPMEEATTGPPAAGVSLDPSARILKEYNPFEEEDEEEEAVAGNPFIQPDSPAPNPFSEEDEHPQQRLSSPLVPGNPFEEPTCINPFEMDSDSGPEAEEPIEEELLLQQIDNIKAYIFDAKQCGRLDEVEVLTENLRELKHTLAKQKGGTD
What is the function of this protein?
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes.  Required for endosome fusion either homotypically or with clathrin coated vesicles.  Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes.  Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane.  Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713).  Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388).
What are the official names of this protein?
Rabenosyn-5, 110 kDa protein, FYVE finger-containing Rab5 effector protein rabenosyn-5, RAB effector RBSN, Zinc finger FYVE domain-containing protein 20.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Note=Enriched in endosomes that are in close proximity to clathrin- enriched regions at the cell surface.
Protein: SIRB_ARATH
Sequence: MTTQSQFLVNLSYGGLASQSNLRANNRVSPSSCQITRTNRSWALPVSFKVEKFQLQRGRRRRGSPCFGESEGLVKNGIGDADGIIIVDHGSRRRESNLMLEEFVKMFKEKTGYPIVEPAHMELAEPSIKDAFSLCVQQGAKRVVVSPFFLFPGRHWHTDIPSLTADAAKEFSGISYLITAPLGPHNLLLDVVNDRIQHCLSHVEGDADECLVCAGTNKCKLYNSS
What is the function of this protein?
Chelates iron to the siroheme precursor.  Catalyzes the last step of the siroheme biosynthesis.  Unlike its counterparts in bacteria, contains an [Fe-S] cluster which is not involved directly in the enzymatic reaction, but may play regulatory role in iron, sulfur and tetrapyrrole metabolism (PubMed:15545265, PubMed:22414210).  The [Fe-S] cluster is required for normal plant growth (PubMed:22414210).
What are the official names of this protein?
Sirohydrochlorin ferrochelatase, chloroplastic, AtSirB.
What is the protein family that this protein belongs to?
Belongs to the CbiX family. SirB subfamily.
Protein: IF2_RHOJR
Sequence: MAGKARVHELAKELGVTSKELLATLKEQGEFVKSASSTVEAPVARRLRESFPSAKSADSAARPAAKPGAPAPSTPATAAKPGGPRPGPKPAAPAPAPVAPAAAAPAATPEAQAPAPAAPAARAVTPAAPATNAPKPGRPTPAAPAPAAPAPAAPAAPAAPAASAPAAPSTGAKPGGPRPGPKPPRVGNNPYSSAPAERPAPRPAPGAPRPGAPRPAPGQGGPRPAPGQGGPRPAPGQGGPRPAPGQGGPRPAPGQGGPRPSPGSMPPRPNPGAMPARSARPAPGGRPGRPGGAPGGRPGGGGGGYRGGGAPGAGAGAPGGGAPAGGFRGRPGGGGRPGQRGAAAGAFGRPGGAPRRGRKSKRQKRQEYDSMQAPAVGGVRLPRGNGETIRLARGASLSDFAEKIDANPAALVQALFNLGEMVTATQSVNDETLELLGGEMNYVVQVVSPEDEDRELLDSFDLTYGEDEGGEEDLESRPPVVTVMGHVDHGKTRLLDTIRKANVREGEAGGITQHIGAYQVLTELDGNERLVTFIDTPGHEAFTAMRARGAKATDLAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGANPDKIRQQLTEYGLVAEEYGGDTMFVDISAKLGTNIDALLEAVLLTADAALDLRANPDMDAQGVAIEAHLDRGRGPVATVLIQRGTLRVGDSIVAGDAYGRVRRMVDEHGDDVLEALPSRPVQVVGFTSVPGAGDNLLVVDEDRIARQIADRRNARKRNALAAKSRKRISLEDLDSALKETSQLNLILKGDNSGTVEALEEALHGIEIDDEVQLRVIDRGVGGVTETNVNLAAASNAIIIGFNVRAEGKATELANREGVDIRYYSVIYQAIDEVEKALKGMLKPIYEEVELGKAEIRAMFRSSKVGNIAGCLVTSGTIRRNAKARLLRDNTVVAETVTISSLKREKEDVVEVREGYECGLTVTYSDIKVGDVIEAYELREKPRD
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFH_ESCF3
Sequence: MPGKIAVEVAYALPEKQYLQRVSLQEGATVEEAIRASGLLELRTDIDLTKNKVGIYSRPTKLSDTVHDGDRVEIYRPLIADPKELRRQRAEKSANK
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: MON1_CHAGB
Sequence: MARETEVESSHDGPPKVTETSPSPSPSPPPPPLPPRQMISSDSPAQVAPAQAKPTTAVSSIDISTVSFPDGSRGTFSTSAPRVGFTPHTNASGYGTPGRDATGGDLADSMSVMSFAPTLRPHGDLASLVADGLNKKSRAWNMLRSQSETVQPFESIELGAPGSLAGFEREFDEIPDDKTDDIRMAIWKSKMKHYMILSSAGKPIYSRHGDLGLVNSYMGVVQTIISFYEGANNPLLGFTAGNARFVIAIEGPLYFVAISRLNESDAQLRSQLEALYMQILSTLTLPTLKSIFVHRPSTDLRKPLEGTESLLSSLADSFTRGSPSTLLGALECLKLRKSQRHAINNVFLKNRSEKLLYGLVVAGGKLVSVIRPRKHSLHPSDLQLIFNMLFESGGIKSGGGESWIPLCLPAFNNRGYLYMYVSFFDGNADPAFSAESTAEDTPESSTDTNTTNTTEKEDEIALILISPDKESFYDLKEMRDKLAAQLTKTGHLSLIRSAARERRPQIQTIAPGAQIAHFLYKSRANVQFCMSALEPANPNPTPGTSSTTPTTVATTATVASTSTSTLEPEKMLTRRRLMTLYHELHASMHAKHAHLKVLHAVSEDAASLAWITPVFEFYCVAGPNAPRAAMAQGANRVIQWAKREEERLFIIGGGVF
What is the function of this protein?
Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
What are the official names of this protein?
Vacuolar fusion protein MON1.
What is the protein family that this protein belongs to?
Belongs to the MON1/SAND family.
What are the subcellular locations of this protein?
Endosome, multivesicular body membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Protein: QUEA_NITWN
Sequence: MRTDLFDFELPAGSIALRPASPRDSARMLVVQPGSGVRDQQVSDLPEWLRPGDQLVVNDTRVIAAQLHGRRIGREAEPRIDATLIKRLDGSRWSALVRPARKLMAGDIVRLGNEGRVCFLGHLDARVESKGEEGEVTFAFSFHGPMLDQAIAELGSTPLPPYIASKRAPDDRDASDYQTMFATHEGAVAAPTAGLHFTPEIETALRGRGVGLHRITLHVGAGTFLPVKVDDTAGHRMHSEWGAISTETADALNAARSRGGRIVAVGTTSLRLLESAADDDGRIKPFTGETAIFITPGHRFRAVDILMTNFHLPRSTLFMLVSAFSGLETMKQAYAHAISAGYRFYSYGDACLLFPERAGA
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.