PharMolix/UniProtQA huggingface dataset:
Protein: METK_LARHH
Sequence: MSEYLFTSESVSEGHPDKVADQISDAILDAILTQDKHARVAAETLVNTGLVVLAGEITTHANVDYIHVARETIKRIGYNTSDLGFDAKGCAVLVGYDKQSPDIAQGVNEGQGIDLNQGAGDQGLMFGYACDETPTLMPFPIYYAHRLVQRQAELRKDGRLPWLRPDAKSQITCAYDSETGLPKRIDTVVLSTQHSPDISHDMLTEAVIEDIVKPVLPAHMLTAETKFLINPTGRFVIGGPMGDCGLTGRKIIVDTYGGAAPHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLARQCQIQVSYAIGIAEPTSISVDTFGTNAIPNEKIVELVKRHFDLRPKGIIQMLDLLRPIYTKTAAYGHFGREEPEFTWEATDKAAALRADAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_MYCGI
Sequence: MPIIEQVGAREILDSRGNPTVEVEVGLLDGTVARAAVPSGASTGEHEAVELRDGGSRYLGKGVEKAVEAVLDEIAPAVIGLGADEQRLVDQALLDLDGTPDKSRLGANAILGVSLAVAKAAAQSAELPLFRYLGGPNAHILPVPMMNIINGGAHADTGVDVQEFMIAPIGAPSFKEALRWGAEVYHSLKSVLKKQGLSTGLGDEGGFAPDLPGTKAALDLIGTAIEGAGLKIGSDVALALDVAATEFYTDGTGYAFEKETRTAEQMAQFYEQLIGAYPLVSIEDPLSEDDWDGWVALTSAIGDRVQLVGDDLFVTNPERLEDGIERGAGNALLVKVNQIGTLTETLDAVSLAHHAGYKTMMSHRSGETEDTTIADLAVAVGSGQIKTGAPARSERVAKYNQLLRIEEELGDAARYAGDLAFPRFGVESK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: PYRB_METMP
Sequence: MRHLISMRDIGREEILNILDESERMEAILNEKGHCDFLNGRILATLFYEPSTRTRLSFETAMKRLGGNVIGFTDISNTSVTKGESLADTIKVISGYSDLIAIRHPSEGAARLSSENSKVPVINAGDGSNQHPTQTLLDLYTIKREVGHIENLKIAFIGDLKYGRTVHSLCQALSLFKGVEIKLISPDELKMPREVIEDIAGKIKLSEMADVDIDDVDVVYMTRIQKERFVDVNEYYKVKGIYRLSKEHIGEKNVVIMHPLPRVDEIDSEVDNIPQARYFKQSFYGVPVRMAILKLLFEDSVK
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: PHA2_YEAST
Sequence: MASKTLRVLFLGPKGTYSHQAALQQFQSTSDVEYLPAASIPQCFNQLENDTSIDYSVVPLENSTNGQVVFSYDLLRDRMIKKALSLPAPADTNRITPDIEVIAEQYVPITHCLISPIQLPNGIASLGNFEEVIIHSHPQVWGQVECYLRSMAEKFPQVTFIRLDCSSTSESVNQCIRSSTADCDNILHLAIASETAAQLHKAYIIEHSINDKLGNTTRFLVLKRRENAGDNEVEDTGLLRVNLLTFTTRQDDPGSLVDVLNILKIHSLNMCSINSRPFHLDEHDRNWRYLFFIEYYTEKNTPKNKEKFYEDISDKSKQWCLWGTFPRNERYYHK
What is the function of this protein?
Catayzes the decarboxylation/dehydration of prephenate to phenylpyruvate.
What are the official names of this protein?
Probable prephenate dehydratase, PDT, Phenylalanine-requiring protein 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y444_JANSC
Sequence: MLTVISPAKRLDWAKRELATTAPDFMDDAVTLARAAKRLSQADLRKLMDISADLAKLNADRFKVFEEAPEGERPAALAFAGDTYIGLEATSLDADTMDYAQDHLRILSGLYGLLRPLDAIRPYRLEMGSRLKTRKGPSLYAYWGPRLAQALNVQAKAVDTKTLINCASVEYFSAVDEKALDLDIVTPQFFEDKPGGPKIVSFFAKKARGAMARFVQERRLTSPHQILDFDTGGYSHAPDLSAPGKPAFLRSEAAQKAA
What are the official names of this protein?
UPF0246 protein Jann_0444.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: ARLS_STAEQ
Sequence: MIKRQKLKYKWMLITTLITFTTILLFCLIIIFFLKDTLRSSEIDEAERSSNDIANLFHSKSLSDISALDLNASLENFQEILIYDDKGRKLIQTSNDNTLAYDNKIDFKHPERIHIHRSHGINYLVITEPIRSKEFSGYSVLVHSLQNYDNLVKSLYIVALAFGLIATIITAGVSYIFSSQITKPIVTMSNKMNQIRRDGFQNKLELTTNYEETDNLIDTFNEMMYQIEESFNQQRQFVEDASHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEVNRITKLVEELLLLTKDRVNHNVLECENVDINSEIQSRVKSLQHLHPDYTFETHLATKPIQLKINRHQFEQLLLIFIDNAMKYDTEHKHIKIVTQLKNKMIMIDITDHGMGIPKADLEFIFDRFYRVDKSRARSQGGNGLGLSIAEKIVQLNGGMIQVESELQNYTTFKISFPVLN
What is the function of this protein?
Member of the two-component regulatory system ArlS/ArlR.  ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity).
What are the official names of this protein?
Signal transduction histidine-protein kinase ArlS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UPPS_XANCP
Sequence: MASTAMHSEPSAAAVPRHLAIIMDGNGRWAQRRRRPRVIGHRAGARAVNRTIDFCLDKGVSALTLFAFSSENWGRPQDEVDALMKLFLHALDRGVEELQRRGVQVRFIGDRSRFTAPLRDRMAGAERITAANTRLVLSIAASYGGRQDIAMAARALAVEVAAGRLQPEQIDEALLASRVALADLPAPDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDYAGRERRFGLTSAQIAEKATEASSA
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP).  UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
What are the official names of this protein?
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), Ditrans,polycis-undecaprenylcistransferase, Undecaprenyl diphosphate synthase, UDS, Undecaprenyl pyrophosphate synthase, UPP synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: PRSA_CLOBK
Sequence: MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQVLSQIKTQYGEEFEKSEQGKEVIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEADKKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLKDQIVIEKVINEVTKDVKVEDKDAQKYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDTGSKDKGGLLGDISYSDSNFDPTFMKAAIALKSGAISNPVHTQFGYHIIKINSKKEYPVKKFDSVKEDIKKQLKQEKQQEAYTKKIEEWKKASKIKTYEKNLL
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: FMT_DINSH
Sequence: MRLVFMGTPAFSVPVLDALVAAGHEVAAVYCQPPRPAGRGKKPRPSPVQARAEVLGLAVRHPVSLKGAEAQADFAALGAEIAVVVAYGLILPQAVLDAPEHGCWNIHASLLPRWRGAAPIHRAILAGDAETGVCIMQMEAGLDTGPVLLREAVAIGAEETTGGLHDRLSALGARLIVEALARRAELVPEPQPEVGVTYAAKIDKAEARVDWSRPAVEVDRLIRGLSPVPGAWCEIAGERVKLLGSRLAEGSGAAGQVLEGFTLACGVGAVEITRAQRAGRKAADAAEILRGMTLPARLD
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: TILS_ACTP2
Sequence: MLLDTLQTQFRHYFPTQRNFVLGLSGGIDSIVLLHLLAELQLNLRAVHIHHGLSPNADNWAAFCEQVCKRLKIPFILQKVTVDRSEGIEAGARAARYQAIGEIIQPNEVLVTAHHLDDQTETFLLALKRGSGIKGLSAMQAVGFWQNFTIFRPLLNVSKAQIEQYALQQQFTWIEDESNHDSHYDRNFLRNEVLPIVNQRWQHFSQMVARSAQHCAEQQMLLEELLAQELQRYADFSEKRLNIEAFPQFSLAKQQQLIRLWLEKCGAQMPSTAQLMQIIQQTIYADVDKNPQLKLADFWLRRYQHHLYLTGELLEPDDFCQPLFAQQSLTLPDGIGELQHLGDSIIYQKSGKIDRLLLPKALVNAPLQVKLTHQGKVKQYGKPMREEMKKRYQQAQVPVWLRKRTPLIFFHDQLVFICH
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETA_VIBC1
Sequence: MQQHYDYIIVGAGSAGCVLADRLSESGQHQVLLLEAGGSDKSIFIQMPTALSYPMNTEKYAWQFETVAEEGLDGRQLHCPRGKVLGGSSSINGMVYVRGHACDFDEWEAEGAKGWNYQACLPYFRKAETWTGGADEYRGGSGPVGTCNGNDMKLNPLYQAFIEAGKDAGYPETQDYNGYQQEGFGPMHMTVDKGVRASTSNAYLSRAKKRSNFTLMKGVTAHRILLEGKKAVGIEFEQSGEIKQCFANKEVVSSAGSIGSVQLLQLSGIGPKTVLDKAGIEVKHTLEGVGKNLQDHLEVYFQYHCKQPITLNSKLGLISKGLIGTEWILTRKGLGATNHFESCAFIRSREGLKSPNIQFHFLPAAMRYDGRAAFDGHGFQVHVGPNKPESRGSVEVVSANPNDKPKIEFNYISTEQDKQDWRDCIRLTREILNQPAMDAFRGEEIQPGLNITSDEAIGEWVKQNVESAYHPSCSCKMGSNDDPMAVLNEACQVRGIEGLRVVDSSIFPTIPNGNLNAPTIMVAERAADMILGNTLEQSNNTPVWIAPNWQETQRMRPPKRDLSSISSIA
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: MDH_NITWN
Sequence: MARDKIGLIGSGQIGGTLAHLIGLKELGDVVMFDIADGVPQGKSLDIAQSSPVEGFDARLAGTNSYEALEGAGVCIVTAGVPRKPGMSRDDLLGINLKVMEQVGAGIRKYAPDAFVICITNPLDAMVWALQKASGLPAKKVVGMAGVLDSSRFRYFLADEFNVSVEDVTAFVLGGHGDSMVPLVKYSTVAGIPLPDLVKMGWTSQARIDEIVDRTRNGGAEIVNLLKTGSAFYAPAASAIAMAESFLRDKKRVLPCAAYLNGEFGVYDMYVGVPVVIGAKGVERIVEIELAGRDREAFDRSVAAVQGLVDACKKIAPDLLDR
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: KTHY_STAS1
Sequence: MSAFITFEGPEGSGKTTVIQQVAQKLENQYSVVLTREPGGVKTGEQIREVLLEGDDMDDRTEALLFAASRREHLVGKVIPSLENGKLVLCDRYIDSSLAYQGYARGIGIEEVKSINEFAINGLYPDITIYLDVSVAVGRERILKNQRNQNRLDQEDVKFHEKVVEGYKKIIHNESERFIVIEADRSIDEVVNATYESISKYLEKL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RAN_TETPY
Sequence: MVDNKQDVVAEFKLVLVGDGGVGKTTFVTRHQTGEFEKRYIATQGVNVSNMILHTTKGAIRFNIWDTAGQEKLGGLREGYYIGADAAIMMFDVTSRITYKNIPKWHKDLTRICENVPIVLVGNKVDSKDSKVKARQITFHRKRSLQYYDVSAKSNYQYEKPFLWILRKLTGDPNLNLVEGIALAPVDIHMTEDQIKQLQMEHDEAMNLAQQGQLPDEEDDEFN
What is the function of this protein?
GTP-binding protein involved in nucleocytoplasmic transport.  Required for the import of protein into the nucleus and also for RNA export.  Involved in chromatin condensation and control of cell cycle (By similarity).
What are the official names of this protein?
GTP-binding nuclear protein Ran, GTPase Ran, Ras-like protein TC4.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ran family.
What are the subcellular locations of this protein?
Nucleus.
Protein: WHIB1_MYCTU
Sequence: MDWRHKAVCRDEDPELFFPVGNSGPALAQIADAKLVCNRCPVTTECLSWALNTGQDSGVWGGMSEDERRALKRRNARTKARTGV
What is the function of this protein?
Acts as a transcriptional repressor, inhibiting expression in vitro.  Probably redox-responsive.  The apo- but not holo-form binds to its own promoter as well as that of groEL2.  Oxidized apo-form and nitrosylated holo-form also bind DNA.  The apo-form has been shown to act as a protein disulfide reductase (PubMed:17157031) (PubMed:19016840), but also not to act as a protein disulfide reductase (PubMed:20929442).
What are the official names of this protein?
Transcriptional regulator WhiB1.
What is the protein family that this protein belongs to?
Belongs to the WhiB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSH2C_ARATH
Sequence: MVVATTIALYASPPSSVCSTPHQISCDLDLTSRSSSTSSSMASSPQKPIVGGLSSLFSSASVKSSSSSSCSYSTGVDEFSSLRYDRSDDLKDLSFSSSFGYSPAKFVNSFRRDHQSPISVLHGPVSCSCSPPMRMSRDRNLDGSFRLGASGLFNGFVRKALGSCVDYEFGSDSVLVDELTFPMEVDTIKPYARDLLRRAQLRHKIFNDESVIKAFYEAEKAHRGQMRASRDPYLQHCVETAMLLANIGANSTVVVAGLLHDTIDDSFMSYDYILRNFGAGVADLVEGVSKLSQLSKLARENNTACKTVEADRLHTMFLAMADARAVLIKLADRLHNMKTLYALSPVKQQRFAKETLEIFAPLANRLGISTWKVQLENLCFKHLYPNQHNEMSTMLEDSFDEAMITSAIEKLEQALKKAGISYHVLCGRHKSLYSIYSKMLKKKLTVDEIHDIHGLRLIVDNEGDCYKALGVVHSLWSEVPGKLKDYITHPKFNGYQSLHTVVMDNGTVPLEVQIRTQEMHLQAEFGFAAHWRYKEGGCKYSSFVLQMVEWARWVVTWHCEAMSKDRSSISSSDSIKPPCKFPSHSEDCPASYKPNSSQDGPVYVIVIENDKMSVQEFPASSTVSDLLSRAGPGSSRWSMYGIPAKEELRPRLNQIPVSDLKWKLKMGDVVELTPTIPDESLTEYREEIQRMYDRGLAFSRPGTMVGWGS
What is the function of this protein?
Possesses ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase activity in vitro and is able to functionally complement E. coli relA mutants.  May be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses.
What are the official names of this protein?
Probable GTP diphosphokinase RSH2, chloroplastic, RelA/SpoT homolog 2, AtRSH2, ppGpp synthetase RSH2.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RUTB_KLEP3
Sequence: MITLPARPESLTFAPQQSALIVVDMQNAYASQGGYLDLAGFDVSATRPVIVNINTAVAAARAAGMLIIWFQNGWDDQYVEAGGPGSPNYHKSNALKTMRQRPELQGKLLAKGGWDYQLVDELTPQEGDIVLPKPRYSGFFNTPLDSILRSRGIRHLVFTGIATNVCVESTLRDGFFLEYFGIVLEDATHQAGPAFAQQAALFNIETFFGWVSDVESFCHALSPATPLSLAKEKRYA
What is the function of this protein?
Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate.  The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.
What are the official names of this protein?
Ureidoacrylate amidohydrolase RutB.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family. RutB subfamily.
Protein: MNMG_BURO0
Sequence: MLFPTEFDVIVVGGGHAGTEAALASARMGAKTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDALGGAMAAATDESGIQFRILNSSKGPAVRATRAQADRILYKAAIRHRLENQPNLWLFQQAVDDLMVEGDRVVGAVTQIGIRFRARAVVLTAGTFLDGKIHVGLNNYTGGRAGDPAAVSLSSRLKELKLPQGRLKTGTPPRIDGRTIDFSKLDEQPGDLDPIPVFSFLGRAEQHPQQLPCWVTHTNERTHDIIRGGLDRSPMYTGVIEGVGPRYCPSIEDKIHRFASKESHQIFLEPEGLTTHEFYPNGISTSLPFDVQLELVHSMRGLENAHILRPGYAIEYDYFDPRALKASLETKAINGLFFAGQINGTTGYEEAAAQGLLAGLNAGRYVQEKDAWCPRRDQAYLGVLVDDLVTRGVAEPYRMFTSRAEYRLSLREDNADMRLTEIGRELGLVDDARWDAFSRKRDAVSRETERLKSTWVTPKTLPAEEATALLGKAIEHEYSLAELLRRPGVSYDGVCGLKGGECGPAEPLADDPVLLEQIKEQVEIGIKYQGYIERQASEIERNDANENTRLPDGIDYREVRGLSFEVSQKLNEFRPETIGQASRISGVTPAAISLLMVHLKRRGLGRRNGKAAEAAEQGGGAVPTQQ
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
Protein: RTCB_PIG
Sequence: MSRSYNDELQFLEKINKNCWRIRKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG
What is the function of this protein?
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.  May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
What are the official names of this protein?
RNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low.
Protein: COX23_COCIM
Sequence: MSAQAGAAQANEDESHKYWGKAEQQFKHKPASQFFDPCQEFADRSIKCMRRNAGDRDMCTDYFQAYRDCKKAWMTQRKEASR
What is the function of this protein?
Required for the assembly of cytochrome c oxidase.
What are the official names of this protein?
Cytochrome c oxidase-assembly factor COX23, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COX23 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: BIOA_MYCTU
Sequence: MAAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAWLTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGDTFLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDLRDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTADVAHTISAGAAGALMHGPTFMANPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLRPFRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP
What is the function of this protein?
Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA).  It is the only aminotransferase known to utilize SAM as an amino donor (PubMed:20565114, PubMed:16984394).  Can also use sinefungin but not S-adenosylhomocysteine as substrate (PubMed:20565114).
What are the official names of this protein?
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, 7,8-diamino-pelargonic acid aminotransferase, DAPA AT, DAPA aminotransferase, 7,8-diaminononanoate synthase, DANS, 7,8-diaminopelargonic acid synthase, DAPAS, Diaminopelargonic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP7A1_HUMAN
Sequence: MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:2384150, PubMed:21813643).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:2384150, PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:21813643).  Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis.  Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (PubMed:12077124, PubMed:19965590, PubMed:2384150).  7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol (PubMed:11013305, PubMed:12077124).  Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (PubMed:21813643).
What are the official names of this protein?
Cytochrome P450 7A1, 24-hydroxycholesterol 7-alpha-hydroxylase, CYPVII, Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Protein: CFA91_MACFA
Sequence: MSHAVTIQEPQAQPQVSQTRYRERSRAGSHISSNRAYDFLYDPLFIVSSEKDHTQANIQATLIRSRLRKVPRFKTMFSNLIHYPRYSLYWSKSDPVPPFISRQWKGHEEKHREALRQLAITDTSFQMPREVYEDPEVTGKNRYKYFERPFLPFFQQMPFNVVYAISKAEPYTFPPTSTKQLSIPSKLTVGTQTDYRDADVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEATLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELLRKREENQNEVNMKHLNARWSKLQEAKEAKMATIQRTHVSTIRKLVGKGKNIEGKLERRNITKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESRLPDFVTQPRIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEARKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEIEMAVIYLQKLLRGRVIQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRIREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSCTESMVQKRLTEGQQDEASNAAMLLEKEIQNENNS
What is the function of this protein?
Involved in sperm flagellum axonemal organization and function (By similarity).  May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).
What are the official names of this protein?
Cilia- and flagella-associated protein 91, CFAP91, AMY-1-associating protein expressed in testis 1, AAT-1, MYCBP/AMY-1-associated testis-expressed protein 1, Protein MAATS1.
What is the protein family that this protein belongs to?
Belongs to the CFAP91 family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, cilium axoneme.
Protein: RBSR_LACLA
Sequence: MTTIKQVALEAGVSKSTVSRFIAQNGYVSDEAREKIERAIKKLNFRPNLSAQSLKTKKNQLVGLLLPDISNPFFPMLAKGAEEFLKEKGYRVMLGNIGEKNQSEQDYLKVLIQSNAAGIISTHDFKEDFPDLDIPTVIVDRVGHKSNYGVFSDNESGGRLAAKVIVTAGAKKVAVVSGPLNATNINNRFKSSIAYLKEKQVDFKAFYSQSYDFEEIQKEAREVLANEENFDSIIAPSDIHAMAYIHEIHRLNKKIPEDIQIIGYDDIQMSQFIYPALSTIHQSAYQMGLEAAQLIYKIATDQAIEKSKIELPVHYVARETIRQKRKE
What is the function of this protein?
Transcriptional repressor for the ribose rbsDACBK operon.
What are the official names of this protein?
Ribose operon repressor.
Protein: SYS_SACS2
Sequence: MSWSILELLRKNPEDLKNNLKRRAIDVSLVDKAVELDKKWRQVLQEVEKLRHQHNVLSSQISKLSGEERKKKIEESKNLLKILEEKEKELEEIENERDRLLSSLPNLVADDVPNGPDDSYNVPIKFWGKFKVYEGDVQEFLKQIKDAKVNYEVIKWKPKGHAEMLEDVLHLGNTLKAAEIAGSRFYYLFNDIVWLDFSLLLFAIDYITQQGYTLVLPPYMLRGEVIQSVIDLDTFKDAIYKIENEDLYLIATAEHPIAAMFFKEEIEKDKLPLKFAGISPAFRKEASAANKDLKGIFRVHQFHKVEQFIFSTPEDSWKYHSELITNAESIFQQLELPYRIVNIASGDLGACAAKKFDLEVWMPAQAKFREMVSCSNCTDWQAFRMKIRYVDRKNNRRGYVHTLNSTAIASTRTITAILENYQREDGVVEVPKVLRKYLEAFPKAPKDYIYPLKNKII
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.