PharMolix/UniProtQA huggingface dataset:
Protein: CCKAR_CAVPO
Sequence: MDVVDSLFVNGSNITSACELGFENETLFCLDRPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPSLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTGNMCRFLLPNDVMQQTWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFDAIQKKSAKERKTSTGSSGPMEDSDGCYLQKSRHPRKLELRQLSPSSSGSNRINRIRSSSSTANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAERHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGTPGVRGEMGEEEEGRTTGASLSRYSYSHMSTSAPPP
What is the function of this protein?
Receptor for cholecystokinin.  Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach.  Has a 1000-fold higher affinity for CCK rather than for gastrin.  It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system.  This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
What are the official names of this protein?
Cholecystokinin receptor type A, CCK-A receptor, CCK-AR, Cholecystokinin-1 receptor, CCK1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: C_CDVO
Sequence: MSAKGWNASKPSERILLTLRRFKRSAASETKPATQAKRMEPQACRKRRTLRISMNHTSQQKDQTMSAMYLKIIRDVENAILRLWRRSGPLERTSNQDLEYDVIMFMITAVKRLRESKMLTVSWYLQALSVIEDSREEKEALMIALRILAKIIPKEMLHLTGDILSALNRTEQLM
What are the official names of this protein?
Protein C.
What is the protein family that this protein belongs to?
Belongs to the morbillivirus protein C family.
Protein: ENV_HTL1M
Sequence: MGKFLATLILFFQFCPLILGDYSPSCCTLTIGVSSYHSKPCNPAQPVCSWTLDLLALSADQALQPPCPNLVSYSSYHATYSLYLFPHWIKKPNRNGGGYYSASYSDPCSLKCPYLGCQSWTCPYTGAVSSPYWKFQQDVNFTQEVSRLNINLHFSKCGFPFSLLVDAPGYDPIWFLNTEPSQLPPTAPPLLPHSNLDHILEPSIPWKSKLLTLVQLTLQSTNYTCIVCIDRASLSTWHVLYSPNVSVPSSSSTPLLYPSLALPAPHLTLPFNWTHCFDPQIQAIVSSPCHNSLILPPFSLSPVPTLGSRSRRAVPVAVWLVSALAMGAGVAGGITGSMSLASGKSLLHEVDKDISQLTQAIVKNHKNLLKIAQYAAQNRRGLDLLFWEQGGLCKALQEQCCFLNITNSHVSILQERPPLENRVLTGWGLNWDLGLSQWAREALQTGITLVALLLLVILAGPCILRQLRHLPSRVRYPHYSLINPESSL
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp62, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: GSM1_YEAS2
Sequence: MTKKLPSELKQTRKSIQTACEFCHTKHIQCDVGRPCQNCLKRNIGKFCRDKKRKSRKRIEKHGTQPYLNLGKRLVIHDVPSKTVSPSSVHLQRDFLSSDQEKPGKTPAHNTNIQYTYNINDNFQSAGSIPRITNFNTNNGQTVLENTSNNISASQAVHLMNDPIIPTVRKSTLNLKSHFLEQHKAMQQPLATNCLVATSNVPVHSGMDDSNKSDDDVDDETNIHFDSMWCNDEYMKLKDIVDISTPFLPNNSQIFSLQESEYPNPSASTRGNSSLHLTNLLNSTKSVNDQKDSSIGHSTSTFNTYDEVVSRPFISLDMLHLNRGANANTQPSHNAKLESECDSSSHSDADLEKHDTDFISPSKFRELVKTPQDLYDNKCLIKLHNYKLAYTKLLTTLRKKFLEGAEIDKSASVKDEHSTQKHNLRYDLEVIIRSILERYAPIFISLTSNMIEEDLLLQEVTLQRALLDLENMAKLVSCTPMCIWRRSGEICFVSNEFYSLTGFNKNLLLDRTSFIFEYLDHKSVSNYFQIFNELLAFGYNDINKRKKLLMLNACSSTSSKITEGFSFTTDGKAIFTKCNLLLSNGLYLKCACCWTVKRDSFNIPILVMGQFLPIFEMD
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Binds specifically to 5'-CGGN(8)CGG-3' and 5'-CGGN(9)CGG-3' sequences in the promoter region (By similarity).
What are the official names of this protein?
Glucose starvation modulator protein 1.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TIG_HALH5
Sequence: MTAKWEKLEGNEGVLTVDVESAKVDEALDKAFKKVVKKVNVPGFRKGKVPRKIFERQFGVEALYQDALDILLPEAYAAAIDETGIEPVDRPEIDIEQMEQGNNLIFKATVTVKPEVQLGDYKGLEFEEKDTTVSDEDVEQELKSLQERQAELVVVEEEAIQEGDTAVLDFEGFVDGEAFEGGKAENYSLEIGSGQFIPGFEDQLVGLKAGEEKDVEVTFPEEYHAEELAGKPATFKVKIHDVKRKELPELDDEFAKDVDEEVESLDELKKKLREKLEKDRAHEADHEKRDTLIQKASENATIDIPEAMINTELDRMTQEFEQRLQMQGMNLEMYFQFSGQTQEQLREQMKEDAEKRVRVNLTLEAIANQENLEASDEDVEKELEKMAEMYQRSVDEIKSIFATQGGTDGIKADLKIQKAVDFLVEHSKAVS
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
Protein: CYSD_VIBC3
Sequence: MDQQRLTHLKQLEAESIHIIREVAAEFDNPVMMYSIGKDSSVMLHLTRKAFYPGKIPFPLLHVDTDWKFRDMITFRDATAKKYGFDLIVHKNPEGLAAGINPFDHGSSKHTDIMKTQGLKQALNKYGFDAAFGGARRDEEKSRAKERVYSFRDKNHTWDPKNQRPELWRTYNGQINKGESIRVFPLSNWTELDIWQYIYLENIEIVPLYLADVRPVVQRDGMLIMVDDDRMKLREGEQIEHKSVRFRTLGCYPLTGAIESQANTLTEIIEEMLVATSSERQGRAIDHDQSGSMELKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: RS8A_YEAST
Sequence: MGISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGAKRIHSVRTRGGNKKYRALRIETGNFSWASEGISKKTRIAGVVYHPSNNELVRTNTLTKAAIVQIDATPFRQWFEAHYGQTLGKKKNVKEEETVAKSKNAERKWAARAASAKIESSVESQFSAGRLYACISSRPGQSGRCDGYILEGEELAFYLRRLTAKK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
40S ribosomal protein S8-A, RP19, S14, Small ribosomal subunit protein eS8-A, YS9.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLXK_NEIMB
Sequence: MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDGGEGTVDAIRHSLDLEEKCLQVTGPFGQKEVMRYFQKEQLALFEVADLVGLGKIPLEKRNPLQIQTRGIGELIRHLISQEIKEIYIGVGGTASNDGGIGIAAGLGYQFYDEDGNALPVCGQSLLNLASVSTENRYEIPEDVHIRILADVVSPLCGHQGATYTFGKQKGLDSTMFEAVDQAIQDFYEKVSPATLKLKGAGAGGGIAGGLCAFAQASIVSGIDTCLDLIDFDKKVSDVDLVIVGEGRLDRQSLAGKAPIGVAKRTPVGVPVVAICGSLVEDLPSLPFENIQAAFSILEKSEPLEDSLKNASLYLEHTASNIGHLLNMPKI
What are the official names of this protein?
Glycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the glycerate kinase type-1 family.
Protein: MAC1_SCHPO
Sequence: MIRNTLAFLAILFLLIPTALLIIGSVSVPSTRMTLAKVEGTEFGIFGTCTGNGTDCTETSFGYNASSSLIDDFYYKGDKRLVLSKVLITHIISAFLSFLSAIFVFFSIFLVNQAVNIINIIVVFITTLLTCLAFAIELVLFLPHNTWQSYVTAGAIGSDLIAILALCLRSVSISRIGQKSARLEHVDTMNSSYSSYKTDVKYPLALDDKLSSVPTLPKFHDALTSTSEFGPPSDSGDTVGTTQYPGDIKYATGYESTVASPVPSRVAKLSSRDTPSIIADYDEFRKSESSPSRSSVLSTSKPEVHETEGYCPHKTGNRPGFPSLNIPRTRPTTAGIANTQFDLEPYRNRQAGSISSEGTDSRFFDVENQVSVAQTPSVKPEMFPKTARPFAAIHANASSTQLRNTENITHPGIPNHFAKTTSSVFDEPPATRMPQTRSPVNDHSSFPSDLPIKGEMSTNMTGAPRVGSRNNSSNDLHAQAGMLKNVGNGPRNAPRNNSSNNLHAQGGMPMNMRGPRGAPRNNSSGDLHIQSGMPMNGRNGPRDTSRNNSSSDLYAQSGMHPNMNNGHRGAPRNNSSNDLHAHGGMPVNMRGPRNTSRNNSSSEFNAQIPMNLRNGPRNASRSNSSTDLFGQSGIPGNSRGMPTSPNSRNNSALDLSMHGIPLANNSRQFKRPSYGNMSRPSFELNGSRNPSHGSLNTAHAGMGYGPRSMMRDPQNLSNVPPVSNTLDQLSGNADFELPVRGNRNNRRGPGGNRMIR
What is the function of this protein?
Required for correct cell separation at high temperatures.
What are the official names of this protein?
Membrane-anchored protein 1.
What is the protein family that this protein belongs to?
To yeast YOL019W and YMR063W.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell septum. Cell tip.
Protein: DAPD_SHISS
Sequence: MQQLQNIIETAFERRAEITPANADTVTREAVNQVIALLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIEGAESRYFDKVPMKFADYDEARFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYIGQSTRIYDRETGEIHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MICU2_HUMAN
Sequence: MAAAAGSCARVAAWGGKLRRGLAVSRQAVRSPGPLAAAVAGAALAGAGAAWHHSRVSVAARDGSFTVSAQKNVEHGIIYIGKPSLRKQRFMQFSSLEHEGEYYMTPRDFLFSVMFEQMERKTSVKKLTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISYTEYLFLLTILTKPHSGFHVAFKMLDTDGNEMIEKREFFKLQKIISKQDDLMTVKTNETGYQEAIVKEPEINTTLQMRFFGKRGQRKLHYKEFRRFMENLQTEIQEMEFLQFSKGLSFMRKEDFAEWLLFFTNTENKDIYWKNVREKLSAGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQHQSIQEYWKCVKKESIKGVKEVWKQAGKGLF
What is the function of this protein?
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221).  MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927).  MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).
What are the official names of this protein?
Calcium uptake protein 2, mitochondrial, EF-hand domain-containing family member A1.
What is the protein family that this protein belongs to?
Belongs to the MICU1 family. MICU2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: NU2C2_DIOEL
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFHGSFIFPECILIFGLILLLMIDSTSDQKDRPWFYFISSTTLVMSITALLFRWREEPIISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITLFVAPECFSLCSYLLSGYTKRDVRSNEATMKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALISITVGIGFKLSPAPFHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFACIVSFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLHLFWCGWQAGLYFLVSIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIELSMTVCVIASTIPGISMNPILAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: YI42_PSEAY
Sequence: MANTKVADVVTETLHVAGVKRIYGVVGDSLNGITDSLRRRGDIDWIHVRHEESAAFAAGAEAHLTGELAVCAGSCGPGNLHLINGLFDCHRSRVPVLAIAAHIPSAEIGRGYFQETHPESLFRECSHYCELVSSPEQLPGVLESAIRAAVGLRGVAVVIIPGDVALRESNAKPAAGASMALRPPVVQPAAADVDALAQLLNDSGKVTLLCGRGCAGAHDPLVKLAEALKAPIVHAFGGKEYVEYDNPYDVGMTGLIGFSSGYHAMLNCDTLLMLGTDFPYRQFYPADAKIAQVDVRPENLGRRARLDLGMVGDVSATIGALLPKLKARTDRAYLDACLAHYRKAREGLDELPPASRDASPFTHNTWPSWSARQRRTMRFSRSTWARRRSGPRVISP
What are the official names of this protein?
Uncharacterized 42.6 kDa protein in isoamylase 3'region.
Protein: RL36_ACISJ
Sequence: MRVSASVKKICRNCKIIRRKGVVRVICTDQRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: THIL_LEPIN
Sequence: MKENLILKESEVIRILYPPGIVQTDDCYLDEEGRIYTTDTICEGTHFRIEWSGPKEIAQKLVEVNVSDIAAGGGIPTKAFLNLGLSTQCSKEEWILPFSISLQESLSSYNIELCGGDTYRSSSLNLTLTLIGVTTKPWKRSGGKDGDFLYLTGSVGLSLLGYKILKEGLDIPEPLRSLALERHLTPKARLKVSKELSKNSPVSCCMDLTDGLLLDLPKLASSSNLGLKIDLEKIPILSNILTYLSLGEVLSSGEELELIFLSPVELPKTLCETSLTKIGNTTSDWKGVKFFQGNSEKTFEHLGFEHF
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
What are the official names of this protein?
Thiamine-monophosphate kinase, TMP kinase, Thiamine-phosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-monophosphate kinase family.
Protein: SYV_STRMU
Sequence: MSTQLSPKYNPAEVEADRYQKWLDADVFKPSGDQKAKPYSIVIPPPNVTGKLHLGHAWDTTLPDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEARLAEDGISRYDLGREKFLDKVWEWKDEYAATIKEQWGKMGISVDYSRERFTLDEGLSKAVRKVFVELYKKGWIYRGEFIINWDPKARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVATTRPETMFGDTAVAVNPNDDRYKDLIGQNVILPIVNKLIPIVADEHADPEFGTGVVKITPAHDPNDFLVGQRHNLPQVNVMNDDGTMNELAGEFAGMDRFEARKATVKKLEEIGALVEIEKMTHSVGHSERTGVPIEPRLSTQWFVKMDQLAKNAIANQDTDDKVDFYPPRFNDTFLQWMENVHDWVISRQLWWGHQIPAWYNADGDMYVGEEAPEGDGWKQDEDVLDTWFSSALWPFSTMGWPDTDSEDFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGCRPFQNVLIHGLIRDEQGRKMSKSLGNGIDPMDVVDKYGADALRWFLSNGSAPGQDVRFSYEKMDAAWNFINKIWNISRYILMNNEGLSLDQASKNVVLVTNGKAGNVTDRWILHNLNETIAKVTENFDKFEFGVAGHILYNFIWDEFADWYVELTKEVLYSEDEAEKVITRSVLLYTLDKILRLLHPIMPFVTEEIFGQYADGSIVTAAYPTVNPAFENQTAHSGVESLKDLIRAVRNARAEVNVAPSKPITILVKTSDSNLEDFFKANVNYIKRFTNPETLEISSAIATPELAMSAVITGAEIFLPLADLLNVEEELARLNKELAKWQKELDIVAKKLSNDRFVQNAKPEIVQKERDKQIDYQTKYDATVERIKEMEKLIK
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_ESCF3
Sequence: MKPYQRQFIEFALSKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDLDLPYCFNRKEAKDHGEGGNLVGSALQGRVMLVDDVITAGTAIRESMEIIQANGATLAGVLISLDRQERGRGEISAIQEVERDYNCKVISIITLKDLIAYLEEKPEMAEHLAAVKAYREEFGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: TSAD_STAAW
Sequence: MTKDILILAVETSCDETSVSFIKNGRDILSNTVLSQIESHKRFGGVVPEVASRHHVEGITTTINEALVDADVSIEDIDAIAVTEGPGLIGALLIGVNAAKALAFAYDKPLIPVHHIAGHIYANHIEEPLTFPLIALIVSGGHTELVYMKDHLSFEVIGETRDDAVGEAYDKVARTIGLNYPGGPQVDRLAAEGEDTYSFPRVWLDKDSYDFSFSGLKSAVINQLHNQRQKNIPIIEANVATSFQNSVVEVLTFKAIQACKEYGVQRLIVAGGVASNKGLRQSLADQCKVNDIQLTIPSPKLCTDNAAMIGVAGHYLYQQGRFADLALNGHSNIDLEEYSAE
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURT_SACS2
Sequence: MEIGTPLFEGSKKILLLGSGELGKEMAIEAQRMGLEVVALDRYDLAPAMHVAHRKYVVDMMNPNAIKAVVKRERPDAIIAEIEAINTDALIELESNGFRVVPNANAVKACMNRIELRRFAAEKLKLPTTKYAFAENEEEVKRACKDIGFPCLIKPEMSSSGHGHVLVNKIENVEEAYRESISHARGKSRRVIVEEFVKIDTELTVLTYRYHSNSDSIITKTIEPIEHKRPSYYYVESWHPSNVSQGVKETARGIAQKVAEELGGLGIYGVEIIVSGNRILFSEVAPRPHDTGLVTLASSDINEFQIHVRSAIGLPTPEVKLVSPAASHVILAQTENVWGPKFLNIEKAMEIPGVQVRLFGKPVTYEKRRMGVVLATGNSVEEALEKVRKASSIILVK
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: Y1817_CLOBM
Sequence: MHYCNKDIGSFGETIAADYIKNSGYIILERNFRCKLGEIDIIAKDKNFIVFIEVKTRYGYIYGSPSEAITFRKQNKIYKTAQLYIMKKAIHNKFYFRFDVIEVILNTLNSNYSVKLIKNAFQI
What are the official names of this protein?
UPF0102 protein CLK_1817.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: SRX1_YEAST
Sequence: MSLQSNSVKPTEIPLSEIRRPLAPVLDPQKIDAMVATMKGIPTASKTCSLEQAEAAASAGELPPVDVLGVRVKGQTLYYAFGGCHRLQAYDRRARETQNAAFPVRCRVLPATPRQIRMYLGSSLDIE
What is the function of this protein?
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxin TSA1.  May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and as thioltransferase.
What are the official names of this protein?
Sulfiredoxin, Sulphiredoxin.
What is the protein family that this protein belongs to?
Belongs to the sulfiredoxin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RNPA_ECOLU
Sequence: MVKLAFPRELRLLTPSQFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAHERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVADLDNRALSEALEKLWRRHCRLARGS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: PMP11_CHLPN
Sequence: MKTSIPWVLVSSVLAFSCHLQSLANEELLSPDDSFNGNIDSGTFTPKTSATTYSLTGDVFFYEPGKGTPLSDSCFKQTTDNLTFLGNGHSLTFGFIDAGTHAGAAASTTANKNLTFSGFSLLSFDSSPSTTVTTGQGTLSSAGGVNLENIRKLVVAGNFSTADGGAIKGASFLLTGTSGDALFSNNSSSTKGGAIATTAGARIANNTGYVRFLSNIASTSGGAIDDEGTSILSNNKFLYFEGNAAKTTGGAICNTKASGSPELIISNNKTLIFASNVAETSGGAIHAKKLALSSGGFTEFLRNNVSSATPKGGAISIDASGELSLSAETGNITFVRNTLTTTGSTDTPKRNAINIGSNGKFTELRAAKNHTIFFYDPITSEGTSSDVLKINNGSAGALNPYQGTILFSGETLTADELKVADNLKSSFTQPVSLSGGKLLLQKGVTLESTSFSQEAGSLLGMDSGTTLSTTAGSITITNLGINVDSLGLKQPVSLTAKGASNKVIVSGKLNLIDIEGNIYESHMFSHDQLFSLLKITVDADVDTNVDISSLIPVPAEDPNSEYGFQGQWNVNWTTDTATNTKEATATWTKTGFVPSPERKSALVCNTLWGVFTDIRSLQQLVEIGATGMEHKQGFWVSSMTNFLHKTGDENRKGFRHTSGGYVIGGSAHTPKDDLFTFAFCHLFARDKDCFIAHNNSRTYGGTLFFKHSHTLQPQNYLRLGRAKFSESAIEKFPREIPLALDVQVSFSHSDNRMETHYTSLPESEGSWSNECIAGGIGLDLPFVLSNPHPLFKTFIPQMKVEMVYVSQNSFFESSSDGRGFSIGRLLNLSIPVGAKFVQGDIGDSYTYDLSGFFVSDVYRNNPQSTATLVMSPDSWKIRGGNLSRQAFLLRGSNNYVYNSNCELFGHYAMELRGSSRNYNVDVGTKLRF
What are the official names of this protein?
Probable outer membrane protein pmp11, Outer membrane protein 4, Polymorphic membrane protein 11.
What is the protein family that this protein belongs to?
Belongs to the PMP outer membrane protein family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cell outer membrane; Peripheral membrane protein; Extracellular side.
Protein: Y3925_SELML
Sequence: MCFFLSSLCPVVAERCRSLLVPEDSGVDVENGGKRTIPKSRNGMLGEDMDDAAPLESGLSMSDMQMGSFSTLKAAKRAEVGGTGPKVGRPRKLSVYNPREMSDGNPGEDCLVVGPSATVSHSEGLSASGKRRKQHLPFTVDDLDIMCGVPSPRSGAPCRQPLTCKSHSISSKRAVTGRRKPFDALLQDFKDNNSRKSQQADIPRPLATKVYCSGHSQRMRAVITSLYRESISGRSSLPQNEQTLALDANPQQQQQQHTLMSLNKVSECWWIWIKTPFCSGISMTQVRTTEGGDKVEVVLYAAAHLPAFTARRLSGYSLQRNQQAAHSGPIHVARSTLPFENPDFTGV
What are the official names of this protein?
SCA7 domain-containing protein SELMODRAFT_439258.
Protein: MARC1_DANRE
Sequence: MDLKEAFATIFDQNRKVALYAAGTTVAVLGLGLVFKYMRREEKLTRVGVVTKLLVHPLKSGKAVSVEAAECLRMGLKYGELRDRHWLVITEDGHMVTGRQQPRLVLVSLTCEGGHVSLNGPQMEELKFPLNNSSDLVVDCRVFSVDVQGRDCGDKVSEWLTRFLEADKPVRLVHYEPDLKPQRPHEKEPLFPKDDEVAYPDAAPVMLMTEASVGDLNSRLDKDLSVFQFRPSIVVSDCEAFTEDTWDHIRIGEVELKRVIGCGRCLFTTVDPETGVFSRKEPLETLKTYRMTDPKQKTSPILGQYYTVRKTGVLHVGEPVYKITY
What is the function of this protein?
Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles.  As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability.  May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis.  Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.
What are the official names of this protein?
Mitochondrial amidoxime-reducing component 1, mARC1.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Mitochondrial import is mediated by AA 1-36 and requires ATP.