PharMolix/UniProtQA huggingface dataset:
Protein: BETI_YERP3
Sequence: MPKVGMQPIRRQQLIEATMAAVNEVGMHEASIAQIAKRAGVSNGIISHYFRDKNGLLEATMRYLIRHLGEAVKQHLAALSVNDPRARLRAIAEGNFDDSQINSAAMKTWLAFWASSMHSPQLYRLQQVNNRRLYSNLCAEFKRCLPREQAQLAAKGMAGLIDGLWLRSALSGEHFNRQEALLIIHNYIEQQLNIKYKC
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: COW44_CONLI
Sequence: GCEWVSWC
What is the function of this protein?
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa).
What are the official names of this protein?
Contryphan Li1044/Li965.
What is the protein family that this protein belongs to?
Belongs to the O2 superfamily. Contryphan family.
What are the subcellular locations of this protein?
Secreted.
Protein: PDXB_VIBA3
Sequence: MKILIDENMPYAEALFSQLGEVTMKSGRTLTADDLVDVDALMIRSVTKVNESLISKANKLKFVGTATAGMDHVDQELMKERGIFFTAAPGCNKVGVAEYAFSAMMVLAQQQGFSVFEKTVGIIGCGQVGSYLAKCLEGIGIKVLLNDPLKQQEGDTREFTELDTLLEQSDVITLHTPITKTGEFPTHHLINEQVLNNLRADQILINAARGPVVDNQALKARLQKADGFTAVLDVFEFEPEVDFELLPLLAFTTPHVAGYGLEGKARGTTMIFNSYCEFLGTEQRAYASDLLPTAPVPKMKLDRAWDEATLHNLTQLIYDVRKDDALFRRNISTPGSFDKMRKEYWDRREYSAVELTGDESCNLTPLSKLGFMVKPTL
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABP1_SCHPO
Sequence: MGKIKRRAITEHEKRALRHYFFQLQNRSGQQDLIEWFREKFGKDISQPSVSQILSSKYSYLDNTVEKPWDVKRNRPPKYPLLEAALFEWQVQQGDDATLSGETIKRAAAILWHKIPEYQDQPVPNFSNGWLEGFRKRHILHAINEQPTESVVLNNTEPPNDPLSRVYDVTRLTNINDIFTMQETGLFWKLVPNGTPEVEDIKGITRFKARITLTVCCNASGTERLPLWVIGYSQSPRVFRAANVKPEVMNFKWRSNGKASMTTAIMEEWLRWFDACMEGRKVILLIDSYTPHLRAVENIRNSGNDLRNTTVITLPSTSASISQPCSEGVIYALKACYRKHWVQYILEQNELGRNPYNTTNVLRAILWLVKAWTTDISPEIIENAFNLSGVLGLFNESAVTSRALDEMIHPLRELVSEFSVQAAMRIEDFISPSEENIVDSSEDIINQIASQYMDDRAFETDEEESTEFQITTKDAMKAIELLLNYEAQQPDGNPAITISLLNYQKLLEARGGNVNLSRLRST
What is the function of this protein?
Binds, preferentially, to the Maundrell ARS consensus sequence within ARS3002.
What are the official names of this protein?
ARS-binding protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: TIM10_YEAST
Sequence: MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.  Compared to TIM9, it may function as a substrate sensor.
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM10, Mitochondrial intermembrane protein MRS11.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion intermembrane space.
Protein: MURI_JANSC
Sequence: MAVGIFDSGLGGLTVLDAVTKALPDVPLIYMGDNAHTPYGVREADDIYDLTTAGVQHLFDRGCDLVILACNTASAAALRRMQEGWVPEGKRVLGVFVPLIEALTERQWGDNSPPREVDVKEVALFATPTTVSSRAFQRELAFRAIGVDVEAQPCGGVVDAIEDGDMILAEALVRSHVDALKRRMPNPQAAILGCTHYPLVEDVFRAALGDGVAVFSQPSLVADSLGDYLKRRPEMLGSGEPAFLTTGDPKSVEAKATIFLRRKITFEAVG
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: MIPEP_HUMAN
Sequence: MLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFGERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQNSEVMPWDPPYYSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSSPTLLTPSMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVNQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILKETQEKFYGLPYVPNTAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRAAGERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: ARGB_MYCLE
Sequence: MNRTGDDETLSTQVKAEVLAEALPWLKQLHGKVVVVKYSGNAMTDDMLRRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIADDFKGGFRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGITGEDAQLFTAGRRSATVDGMATDIGLVGDVDQVNIAAVLDLISAHRIPVVSTLAPDRDGVVHNINADTAAAALAETLGAEKLLMLTNVEGLYTRWPERDSLVNEIDSAALAQLLPTLEAGMIPKVEACLRAVTGGVPSAHVIDGRVKHCVLVELLTNEGTGTKVVSA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_RICFE
Sequence: MPLSTSLLGKKSTYKDSYDATLLFKIPRINNRNELGINSNNLPFYGVDIWNTYELSCLNKNGKPWVGVGTFYIPTDSENIVESKSFKLYLNSFNNFVVESVEELERIILQDLSNVTHAKVTGRIFPINTKIEFSIPSGKNIDDLDIVCNNYGPPDNSLIEYEDVLVEEEINSNLLKSNCLVTGQPDWGTIVIKYKGKKLKHDSFLKYLISFRNCNEFAEQCAERIFTDIKNAINPDFLSIYIVYTRRGGIDICPYRFTNKSYTLPSDKRFIRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1092_BACVZ
Sequence: MTHWHITSWVVALILVFVSYGLYGSGKAKGAKITHMILRLFYIIIILTGAELFVRFANWNGEYAGKMLLGIITIGLMEMLVIRKKKGKSTGGLWIGFIIVLVLTVLLGLHLPIGFHVF
What are the official names of this protein?
UPF0344 protein RBAM_010920.
What is the protein family that this protein belongs to?
Belongs to the UPF0344 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MNMA_HAEIN
Sequence: MLISNTYNQHFPQLTQEQLARNATKKVICGMSGGVDSSVSAFILQQQGYQVEGLFMKNWEEDDDTDYCTAAADLADAQAVCDKLGIKLHKINFAAEYWDNVFEHFLTEYKAGRTPNPDILCNKEIKFKAFLEYAAEDLGADYIATGHYVRRAGDNENAKLLRGLDPNKDQSYFLYTLSHKQVGQSLFPVGEIEKPIVRAIAEDLGLITAKKKDSTGICFIGERKFKDFLARYLPAQPGNIRTVDDEIIGRHDGLMYHTLGQRKGLGIGGLKNAGDEAWYVVDKDVENNELIVAQGHDHPRLFSKGLIASQLHWVDREPIRESLRCTVKTRYRQQDIPCVIEPIDDETIRVIFDEPQSAVTPGQSAVFYLGEVCLGGGIIAERI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_CLOPE
Sequence: MIDDRKLQILRAIIQDYISTGEPVGSRTIAKKYNLGVSSATIRNEMADLEDMGFLEQPHTSAGRIPSSRGYRLYVDRMIEFERLSSEEEGLIRNSIIDGTLYEVDKIIKQTSALLSELTKMTCIVKAPSVHKSFVKSIQLLKVDDVSILCVLVTDNGVIRNTVIKVKSVPISEELIKISKIITERLKNLTIEQINLEVISNLNRALSGYEDIVNAVLPALYESLKGDETSEVFLEGTINIFNYPEYNNIHKAKEILELLHDKKSISELISDSDDMTVKIGDEIFVPEAKECSIISAGYHVGDKSLGTIALIGPRRINYSKVLSIMTEVMKELNETLKNK
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: ANMK_NEIMF
Sequence: MMETQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPDRLRRQLLDLQDTGADELHRSRILSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHGYSIQLADLPLLAERTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDNRETRAVLNIGGIANISVLPPDAPAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLDRLLAHPYFARPHPKSTGRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVFDAVSHAAADTRQMYICGGGIRNPVLMADLAECFGTRVSLHSTAELNLDPQWVEAAAFAWLAACWINRIPGSPHKATGASKPCILGAGYYY
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: Y3550_NITHX
Sequence: MSAARKRPGTGRRQTDDADTGAPDQSYLDGQLLIAMPVMEDERFARSVIYVCAHSSEGAMGIILNRPAGSVDFADLLVQLDIIKRSDSIKLPETAEAMKVMKGGPVETGRGFVLHSSDFFIEDATLPIDDGVCLTATLDILEAIAKGAGPKHAILALGYAGWAPGQLETEIQDNGWLHCPADPELIFGRDIEDKYTRALHKIGIDPGMLSNEAGHA
What are the official names of this protein?
UPF0301 protein Nham_3550.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: ATPD_SALA4
Sequence: MSEFVTVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENGQNLIRVMAENNRLNALPDVLEQFIHLRAASEATSEVEVTSATALSEEQLSKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PLB_NEUCR
Sequence: MHLPSSLLIAAPLLANVSAEPIRIPQRDVSVVSTSQQLAVRALPDSPSGGYAPAVVDCPKTKPTLRKAVDLSNEEKNWLSIRRKNTIQPMRDLLKRANITGFDSETFMNEAANNISQLPNVAIAISGGGYRALMNGAGFVAAADNRIQNTTGAGGIGGLLQSSTYLAGLSGGGWLVGSLFSNNFSSIETLLSENKVWDFENSIFKGPKEAGLSTVNRIQYWSEVAKEVAKKKDAGFETSITDYWGRALSYQLIGADMGGPAYTFSSIAQTDNFQKAETPFPILVADGRAPGDTIISLNATNYEFNPFETGSWDPTVYGFAPTKYLGANFSNGVIPSGGKCVEGLDQAGFVMGTSSTLFNQFLLANISSYDGVPDVLIEAVTSVLKEIGAKRDDVSQIIPNPFLDWNNRTNPNADTLELDLVDGGEDLQNIPLNPLTQPVRAVDVIFAVDSSADVTNWPNGTALRATYERTFGSISNGTLFPSIPDDWTFINLGLNNRPSFFGCDVKNFTLNANQKVPPLIVYVPNAPYTALSNVSTFDPSYTMSQRNDIIGNGWNSATQGNGTLDSEWPTCVACAVISRSLDRLGRQTPAACKTCFERYCWNGTVNSKDTGVYMPEFKIADAHALDSGAVAIGKMVNVWSSVVVGVVAATLLL
What is the function of this protein?
Catalyzes the release of fatty acids from lysophospholipids.
What are the official names of this protein?
Lysophospholipase, Phospholipase B.
What is the protein family that this protein belongs to?
Belongs to the lysophospholipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: NIRD_ECOLI
Sequence: MSQWKDICKIDDILPETGVCALLGDEQVAIFRPYHSDQVFAISNIDPFFESSVLSRGLIAEHQGELWVASPLKKQRFRLSDGLCMEDEQFSVKHYEARVKDGVVQLRG
What is the function of this protein?
Required for activity of the reductase.
What are the official names of this protein?
Nitrite reductase (NADH) small subunit.
What is the protein family that this protein belongs to?
To B.subtilis NasE.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_XANCP
Sequence: MTAMPRIAFLASPAEPAVAARARLVQRYGDHALHDADIVCALGGDGFMLQTLHRHGAADKPVFGMKLGSVGFLMNQYRDDEDDLLARLQRAEPAHLRPLEMLVQTESGTSAGSLAYNEVSLLRQTRQAAHLSVDLNGQTRIAELIGDGVMVATPAGSTAYNYSAHGPILPLGSHTLALTPIAPYRPRRWRGAILKADTEVRFRVLDPYKRPVSVTADSHEIRDVVEVTIRESTERRVTLLFDPEHNLEERIFSEQFAV
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAPA_ECOK1
Sequence: MPFTLGQRWISDTESELGLGTVVAVDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYSSEQFRMPYSGLRGQRTSLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNKLSNDELNMLGEMIGEQDIEPLLQAANSDSEDAQSARQELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFEGDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYNDLINYLASPDQTEGFDDLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQALAESIEEQDDDTNLIAFAMNLFDIIGINQDDRGDNMIVLTPSDHMLVPDFPGLSEDGITITFDREVALAREDTQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELIYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLNAVNRHTGSKLVNAVQQDVHAILQLGEAQIEKSARALIDAARNEADEKLSAELSRLEALRAVNPNIRDDELTAIESNRQQVMESLDQAGWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: LAMB_SALG2
Sequence: MMITLRKLPLAVAVAAGVMSAQAMAVDFHGYARSGIGWTGSGGEQQCFQATGAQSKYRLGNECETYAELKLGQEVWKEGDKSFYFDTNVAYSVNQQNDWESTDPAFREANVQGKNLIEWLPGSTIWAGKRFYQRHDVHMIDFYYWDISGPGAGIENIDLGFGKLSLAATRSTEAGGSYTFSSQNIYDEVKDTANDVFDVRLAGLQTNPDGVLELGVDYGRANTTDGYKLADGASKDGWMFTAEHTQSMLKGYNKFVVQYATDAMTTQGKGQARGSDGSSSFTEELSDGTKINYANKVINNNGNMWRILDHGAISLGDKWDLMYVGMYQNIDWDNNLGTEWWTVGVRPMYKWTPIMSTLLEVGYDNVKSQQTGDRNNQYKITLAQQWQAGDSIWSRPAIRIFATYAKWDEKWGYIKDGDNISRYAAATNSGISTNSRGDSDEWTFGAQMEIWW
What is the function of this protein?
Involved in the transport of maltose and maltodextrins.
What are the official names of this protein?
Maltoporin, Maltose-inducible porin.
What is the protein family that this protein belongs to?
Belongs to the porin LamB (TC 1.B.3) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: MUTL_BRADU
Sequence: MPVRQLPEQVVNRIAAGEVVERPASVVKELVENAIDAGASRIDVFTDGGGRRRIGITDDGSGMTAKDLALAVERHATSKLDDEDLLQIRTLGFRGEALPSIGSVARLSITTRHAGEPHAWALTVEGGEKSEIMPAALAHGTRVEVNDLFYATPARLKFLKTDRTEAEAIREVVRRLAMARPDVAFTLAGEERAPVTWAAALPGAAGRLTRLGDILGAEFRSHAIEVHAEREGIVVSGYAAAPALTKANALGQYLFVNGRPVRDKLILGAVRAAYSDYLPRDRHPVLALFVTLDPREVDANVHPAKTEVRFRNAGLVRALIVHGLKEALAREGRRTAANSGESALSSFRPAFTPRPASWDWRASPSAPVAPMPSFDGAAAPAFTERAQAAFDVGAPSADVRFETQPVSDLVDRPLGAARTQIHETYIVSQTRDGLIIVDQHAAHERIVYEGLKASLAANGVQRQILLIPEIVEMDEATVERLLERSDELASFGLAIESFGPGAVAVRETPSLLGKTNAGGLLRDLSEHMAEWDEALPLERRLMHVAATMACHGSVRAGRRLRPEEMNALLREMEETPNSGQCNHGRPTYVELKLSDVEKLFGRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: TSAD_SOLM1
Sequence: MLCLGIETSCDETAVALFENGRPVLEKLASQADLHAVFGGVVPELASREHLRRLGPLLQALFAASGRSLADVDAIAVARGPGLLGSLLVGLAAAKGLSLATGKPLIGVDHLHAHLLAATIGRDVAFPALGLLVSGGHTQIVRLESALSLEVLGRTLDDAAGEAFDKAAKSFNLPYPGGVYIDVLGRGIAPDKTLFPRPFLDNDHFDFSFSGLKTAVASYAAAHPELRAGSLAEAGGAIDPEAWPMALRRACSSLNFAIAETLRIKFERALDRQPGPPASLIAAGGVAANGPIRAMLADLAARRGLPLYLPEPALCADNAVMIAAAGSRLAEAGYAHDLALTAVPRGRKVPWDYAGGPSGKAASVDSASPAQ
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILIB_NEOS2
Sequence: MALATPLPATQAAVKVTGPSTVDVSAATTLPVLEAFEVLVRVACVSINHVDGKSADMSPTPGATSGVDFSGLIVALGSKVDSDEFRANNNMRALSIGDRVFGGVFGNNPLRHDNGAFAEYVAVPARLIWHMPAAMDFSTAATIGATLATVGLALFQYLQVPMPSTQTISDSKTIPDPQQKTRMALVYGGGTATGAMAIQVLKLAGFRPITTCSPGSAARAMHLGAAATFDYRSPTCGADLREHTANGLELALDCITDTASMSICYEALGSAGGRYVALDAFPLRGHTRRSVAAEWVCTYTQFGHAVAWVPPYNLDARPRDREIAEAWYVVAQQLVDEGLIEPYPKEDRTGGLAAVGEGMRAVWKGEISGRKLAYPIAEECY
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:31216742).  IliB collaborates with the hybrid PKS-NRPS synthetase iliA to assemble the backbone of ilicicolin H (PubMed:31216742).  The PKS portion of iliA and trans-acting enoyl reductase iliB work together to construct an octaketide, and two methyl groups are introduced by the MT domain of iliA during the chain assembly (PubMed:31216742).  The nascent chain is then condensed with tyrosine, catalyzed by the iliA C domain, and the resulting PKS-NRPS hybrid is offloaded by the iliA RED domain to form an advanced tetramic acid intermediate (PubMed:31216742).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (PubMed:31216742) (Probable).
What are the official names of this protein?
Trans-enoyl reductase iliB, Ilicicolin H biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: RL35_ANASK
Sequence: MPKLKTKSGAKKRFVPKKSGKVKFRRAGVRHLATFGKTKKQKRHLRGTDHLTPMDEKKIKECFPYAR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RL6_LACLA
Sequence: MSRIGNKVIVIPAGVSVEVNGATVTVKGPKGELVRSFNENITLDIAENEITVKRPNDTKEMKMLHGTTRALLANMVEGVSTGFSKALEMIGVGYRAQLQGTKLVLSVGKSHQDEVEAPENIKFVVATPTSIVVEGISKEAVGQTAAYIRSRRSPEPYKGKGIRYVGEYVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RL31B_ECO55
Sequence: MKPNIHPEYRTVVFHDTSIDEYFKIGSTIKTDREIELDGVTYPYVTIDVSSKSHPFYTGKLRTVASEGNVARFTQRFGRFVSTKKGA
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: H2A2_LODEL
Sequence: MTGGKGKSGVAAVAQGASNSRSSKAGLTFPVGRVHRFLRNGNYAQRIGSSAPVYLASVLEYLTAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLGQVTIAQGGVMPYIHQNLLPKKSGKAAV
What is the function of this protein?
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.2.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MDA2_ARATH
Sequence: MDFDFKVSGDFIVSGAEQLDDTDLTRSDEFWLIQAPLGQFPEIEENTLKIEPDKDGLFGEFKDSNAGSLHLCLGAKYDLASFHSQDAGAELIIPSEESMIVGKITRRVALVRYPEPNELLQKMKARTQQKLVGSVTNSSKKSSNLTQSSRHKSGTRSSREKSMFSGFTETPKSPKRKNSESSSGKHRSSTSTVSGSSERSAKSKKKVKKEE
What are the official names of this protein?
Mediator-associated protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: EX7L_THEFY
Sequence: MGMESSPESPQPVRVVLQAVGGWIGRLGRIWIEGQVAELHRRGGMAYITLRDPVANVSARVTCSIRVLRAADPPPEQGARVVVYAKPDFYVPRGTFSFQALEIRHVGLGELLARLERLRQALAAEGLFAESRKRKLPFLPGVVGLICGRDSAAERDVLENARRRWPAVRFEVREVAVQGDRAVPEVMAALEELDAHPEVDVIIIARGGGSLEDLLPFSDEALVRAVAAARTPVVSAIGHEQDTPLLDYVADLRASTPTDAAKKVVPDVGEQWELIRQLRDRARRVLEGGIAREEAWLASMRSRPVLANPVQEVERKIEQVFDLRDRGRRALTAALDRAGDNLAHIRARLHALSPATTLARGYAIVRRADGTVVRSAAEVAPGEELRLRFAEDGLVAIAQNREEDEL
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.