PharMolix/UniProtQA huggingface dataset:
Protein: DTD_ENTFA
Sequence: MKVVIQRVSQAQVAIEEQIVGQIKQGFMVLVGIHQEDTPEDVAYVVGKISKLRVFEDDEGKMNRSIQEIEGSILSISQFTLYAKTKKGNRPSFIEAARPDVAIPLYELFNQQLEAEGIAVATGEFGADMQVSLTNDGPVTIVIDTREK
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOP58_RAT
Sequence: MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASATLSEFLSEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGAENRAKLEARLRILEDRGIRKISGTGKALAKAEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEEVDKEDEITEKKAKKAKIKIKAEVEEEMEEAEEEQVVEEEPTVKKKKKKDKKKHIKEEPLSEEEPCTSTAVPSPEKKKKKKKKKDAED
What is the function of this protein?
Required for 60S ribosomal subunit biogenesis (By similarity).  Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.  Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
What are the official names of this protein?
Nucleolar protein 58, Nopp140-associated protein of 65 kDa, Nucleolar protein 5.
What is the protein family that this protein belongs to?
Belongs to the NOP5/NOP56 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: RBSD_PSEFS
Sequence: MKKTPLLNIALSRVIASLGHGDILVIGDAGLPVPPGVELIDLALTQGIPDFISALRIVLSEMQVESHVLAEEILLKQPPALNELNTLSDEAALGERRLVSHEAFKQLSRKARAVVRTGECQPYCNIALVSGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_PHYMT
Sequence: MIILSIETSCDETSASVTQDGKKVISNIVFSQIKEHSLNGGVIPELASREHLKNITLVLEKSLKEANIQPQEIDLVAFTQGPGLIGSLLVGINCALVFGYIYKKPVLGVNHLLGHIYAAQIENEIEFPSLVLIISGGHTELLALENYLQIKKLGFTCDDAVGEAYDKVSRILGFGYPGGPIIDELAQKGKDIFNFVRPYLKNDNFNFSFSGLKSSIFNLVSKNNFNLQEKINICSSFQSSVIDVLVEKTKRVLKKYSFKQLIITGGVAANYSLRKRFLSEFSQLKVIIPSLKYCGDQAAMIGIAAYYQFKYQLKFNQNYHWEGKPNLSF
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_FRATF
Sequence: MFQSLIAIDYGKARIGIASGQMITKTATPIGTVEAYDGVPNWIELDKIIKRWNPSDIIIGLPLDTQNFETDITKSAKDFAKEVQQRYQRKVHLINEAYSTREARWRLEEVKSKKVSHIKVDALAACVILETWMSEN
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_CLOBK
Sequence: MRVKVTLACTECKRRNYNTMKNKKNDPDRLEMNKYCPHCHKHAAHKETK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RND3_RAT
Sequence: MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRISHMPSRPELSAVATDLRKDKAKSCTVM
What is the function of this protein?
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
What are the official names of this protein?
Rho-related GTP-binding protein RhoE, Rho family GTPase 3, Rnd3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
Protein: PHOP_SALT1
Sequence: MMRVLVVEDNALLRHHLKVQLQDSGHQVDAAEDAREADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSSDVSLPVLVLTAREGWQDKVEVLSSGADDYVTKPFHIEEVMARMQALMRRNSGLASQVINIPPFQVDLSRRELSVNEEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPHDVITTVRGQGYLFELR
What is the function of this protein?
Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides.  Essential for intramacrophage survival of S. typhimurium.  In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG).  In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG.  Essential for transcription of spiC inside macrophages by controlling the expression of the two-component regulatory system SsrB/SpiR (SsrA) and Pir at transcriptional and post-transcriptional levels respectively.  Promotes expression of the two-component regulatory system PmrA/PmrB via activation of pmrD gene.  Is required to attenuate bacterial growth within fibroblast cells and to enhance bacterial resistance to bile in intestinal cells.  Negatively regulates prgH, which is required for invasion of epithelial cells.  PhoP uses multiple mechanisms to promote transcription and activates promoters for PAG at low (uM range) Mg(2+) concentrations.  Probably involved in acid tolerance.
What are the official names of this protein?
Virulence transcriptional regulatory protein PhoP.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCPB_LACP7
Sequence: MEIKKLEAMIEAILFTMGEAVEVERIASALDHDVDTIRKIIHNMMDRYEGDERGIKIIELDNSFQMCTKAQMYEAIVKIAHVPKKHILTDVLLESLSIIAYKQPITKQQIESIRGVKSDHAVNKLVEYNLVCEVGRMDAPGRPILFGTTEDFLRNFGIASLEDLPVVAPEKVADFKMEAEEEVQLQLDI
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: REEP2_BOVIN
Sequence: MVSWIISRLVVLIFGTLYPAYSSYKAVKTKNVKEYVKWMMYWIVFAFFTTAETLTDIVLSWFPFYFELKIAFVIWLLSPYTKGSSVLYRKFVHPTLSNKEKEIDEYITQARDKSYETMMRVGKRGLNLAANAAVTAAAKGQGVLSEKLRSFSMQDLTLIRDEDALPLQGPDGRLRASPGSLLDTIEDLGDDPTLSVRSGTNQADPRTEISEDDTGDKAPKRVKPIKKVPKPEPPASKTLKTRPKKKTSAGGDSA
What is the function of this protein?
Required for endoplasmic reticulum (ER) network formation, shaping and remodeling.  May enhance the cell surface expression of odorant receptors (By similarity).
What are the official names of this protein?
Receptor expression-enhancing protein 2.
What is the protein family that this protein belongs to?
Belongs to the DP1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IF3_BRUAB
Sequence: MRRPFRATPVQKDGPRSNRDIRVPRVQLIDAEGQNHGDVSIQEAMAMAEEAGLDLVEIVPNAEPPVCKIVDLGKLKYQNQKKAAEARKKQKTVEIKEIKMRPNIDTHDYEVKMKAAQRFFEEGDKVKVTLRFRGREMAHQELGMKLLQRVKEDTVEIAKVESEPKLEGRQMMMVLAPR
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_SALG2
Sequence: MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITEETLAKLQDLAKLQDLAGAIKSMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDLGPFMVTEALRPYKNHLTMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAMDKHFSTTPAEKNLPILLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGAILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGLINRYKAWRA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XYLA_XANC5
Sequence: MSNTVYIGAKEYFPGIGKIGFEGRDSDNPLAFKVYDANKTIGDKTMAEHLRFAVAYWHSFCGNGADPFGPGTRAYPWDAGTTALNRAEAKADAAFEFFTKLGVPYYCFHDIDLAPDADDIGEYEKNLKHMVGIAKQRQADTGIKLLWGTANLFSHPRYMNGASTNPDFNVVARAAVQVKAAIDATVELGGENYVFWGGREGYACLHNTQMKREQDNMARFLTLARDYGRAIGFKGNFLIEPKPMEPMKHQYDFDSATVIGFLRQHGLDQDFKLNIEANHATLSGHSFEHDLQVASDAGLLGSIDANRGNPQNGWDTDQFPTDLYDTVGAMLVVLRQGGLAPGGLNFDAKVRRESSDPQDLFLAHIGGMDAFARGLEVANALLTASPLEQWRAERYASFDSGAGADFAAGKTTLADLAKHAASNAPQQLSGRQEAYENLINQYLTR
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHS_PARMW
Sequence: MIAMPTLLSADQRQTLPATLPHWTVHEQSISRELVFNDFNEAFGFMSRVALLAEGRNHHPNWSNVYNRVSITLSTHDLGGLSDLDVELAAAIDQLLPA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: F16PA_MICAN
Sequence: MVSNIPFSIPEHSLDRDCTTLSRHVLQQLQSFSSDAQDLSAIMSRIALAGKLIARRLSKAGLMADVLGFTGETNVQGESVKKMDVFANEVFISVFKQSGLVCRLASEEMDKPYYIPENCPIGRYTLLYDPIDGSSNVDINLNVGSIFAIRQQEDNDLDGEARDLLQNGRKQIAAGYILYGPSTILVYSIGRGVHAFVLDPSLGEFILAQENIIIPDHGPIYSTNEGNFWQWDEAIRDYTRYVHRHDGYTARYSGALVGDIHRILMQGGVFLYPGTVKNPQGKLRLIYETAPLAFLIEQAGGKASDGVTNLLDIVPDKLHYRTPLVIGSVEDVKLVESFIADRRHRDRV
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDA3_ARATH
Sequence: MEEVAREEVEIDKDLRRKIKKTVKKILESSNLYKITEIKAREEASLKLDLDLSQDPYKVIVKEEVENFLEEAVKLIGNKLAMLPKRIESTSI
What are the official names of this protein?
Mediator-associated protein 3, DEK-domain containing protein At5g42060, KELP-like protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: 6PGL_PSEPU
Sequence: MGGRGMGISELKLPAAVKVHELADAKTLAATLAHDVAERLRAAIAAKGQACVVLSGGRSPVPFLEKLASEPLDWAKVTVSLADERWVPVEHADSNAGLLARHLLTGAAAKARFVGLYQQAENLDAAALKADQALTGLPPIDVLVLGMGDDGHTASLFPASPNLEAGLDLASTRRCLPLLAPSVPHQRLSMTRSLLASAAFIALSVQGPGKLATLRAALAGNDLTEMPIRAFLHDPLDIYWCP
What is the function of this protein?
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6PGL.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Protein: SYI_HAEIE
Sequence: MTVDYKNTLNLPETSFPMRGDLAKREPDMLKNWYEKNLYQKIRKASKGKKSFILHDGPPYANGNIHIGHAVNKILKDIIIKSKTALGFDSPYIPGWDCHGLPIELKVEGLVGKPNEKISAAEFRQKCREYASEQVEGQKKDFIRLGVLGDWDNPYLTMNFDTEANIIRTLGKVIENGHLYKGSKPVHWCLDCGSSLAEAEVEYEDKVSPSIYVRFPVESADEIEAKFSAQGRGQGKLSAIIWTTTPWTMPSNRAIAVNADLEYNLVQLGDERVILAAELVESVAKAVGVEQVKILGSVKGADLELSRFHHPFYDFTVPVILGDHVTTDGGTGLVHTAPDHGLDDFIVGKQYDLPMAGLVSNDGKFISMTEFFAGKGVFEANPLVIEKLQEVGNLLKVEKIKHSYPHCWRHKTPIIFRATPQWFIGMETQGLRQQALGEIKQVRWIPDWGQARIEKMVENRPDWCISRQRTWGVPMTLFVHKETEELHPRTLDLLEEVAKRVERAGIQAWWDLDEKELLGADAETYRKVPDTLDVWFDSGSTYSSVVANRLEFNGQNIDMYLEGSDQHRGWFMSSLMLSTATDSKAPYKQVLTHGFTVDGQGRKMSKSIGNIVTPQEVMDKFGGDILRLWVASTDYTGEMTVSDEILKRAADSYRRIRNTARFLLANLNGFDPKRDLVKPEEMISLDRWAVACALDAQHEIKDAYDNYQFHTVVQRLMRFCSVEMGSFYLDIIKDRQYTTKASSLARRSCQTALWHIAEALVRWMAPILSFTADEIWQHLPQTESARAEFVFTEEFYQGLFGLGENEKLDDAYWQQLIKVRSEVNRVLEISRNNKEIGGGLEAEVTLYANDEYRALLEQLGNELRFVLITSKVDVKSLSEKPADLADSELEGITVSVTRSNAEKCPRCWHYSDKIGVNPEHPMLCPRCVENVVGNGEVRHFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_ALBFT
Sequence: MARLQQHFREKLAPELMAKFGYTSPMQVPRLTKITLNMGVSEAVADKKVMDHAVSDLGKIAGQKPVVTMSKKAIAGFKIRENQAIGCMVTLRGVQMFEFLDRFVTVALPRVRDFRGISGRAFDGRGNYNIGVKEQIIFPEIEYDKVDALRGLNISITTTAKTDEECKALLTGFRFPFKN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: GPDA_NEIMF
Sequence: MKITVIGAGSWGTALALHFSQHGNRVSLWTRNADQVRQMQEARENKRGLPGFSFPETLEVCADLADALKDSGLVLIVTSVAGLRSSAELLKQYGAGHLPVLAACKGFEQDTGLLTFQVLKEVLPDNKKIGVLSGPSFAQELAKQLPCAVVLASENQEWIEELVPQLNTTVMRLYGSTDVIGVAVGGAVKNVMAIATGLSDGLEYGLNARAALVTRGLAEITRLASAMGAQPKTMMGLAGIGDLILTCTGALSRNRRVGLGLAEGKELHQVLVEIGHVSEGVSTIEEVFNTACKYQIDMPITQTLLQLIRKEMTPQQVVERLMERSARFE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_STAA8
Sequence: MTYNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFVNIRPTTVVKGASSLSPLKEERVEGTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLAASRRGKLTSVDKENVLASSKLWRKVVNEVSQLYPEVTVNHLFVDACSMHLITNPKQFDVIVCENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSLAMCLRESLNQPDAADELEQHIYSMIEHGQTTADLGGKLNTTDIFEILSQKLNH
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAY_HAEIN
Sequence: MNIAEFHQNIEQVWQKIEEELENQGADVDCETQGSVFTITFDNRTQIVINKQEPLLELWIASKLGGFHFAFKNGDWVSNDGQRFWDCFVEACAAHGENVQF
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: ICCB_TALVA
Sequence: MDATLPSIHTALKILGPNNVSVSENTALPVIQPLDILVRVACISINHVDAKSADMSPSPGATSGTDFSGVVVAIGSDVPKESFRSTNGMKPVQIGDRVFGGVFGNNPLRRDNGAFAEYVAVPARLVWHIPGGMDFSTASTLGAAVATVGLSLFQYMQLPMPTTTSTASPDNGPFVLVYGGGTATGAMAIQVLKIAGFRPITTCSSASAGHATELGATATFDYRSPTCGAELREHTGDTLTLALDCITDTASMNICYEALGSSGGRYVALDSFPLRAHTRRSVVPDWVCTYSQFGHPIAWAAPYNLEARPEDLLTAEAWYVVAQKLIDQGLITPHPKEERLGGLAAIGEGMEAVRRGQIKGKKLVYPISNELCAAA
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:30905148).  IccB collaborates with the hybrid PKS-NRPS synthetase iccA to assemble the backbone of ilicicolin H (PubMed:30905148).  The PKS portion of iccA and trans-acting enoyl reductase iccB work together to construct an octaketide, and two methyl groups are introduced by the MT domain of iccA during the chain assembly (PubMed:30905148).  The nascent chain is then condensed with tyrosine, catalyzed by the iliA C domain, and the resulting PKS-NRPS hybrid is offloaded by the iliA RED domain to form an advanced tetramic acid intermediate (PubMed:30905148).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iccA with the partnering trans-enoyl reductase iccB since iccA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iccC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iccD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  Finally, the epimerase iccE converts 8-epi-ilicicolin H into ilicicolin H via epimerization.  IccA to iccE are sufficient for ilicicolin H biosynthesis and the roles of the remaining enzymes, iccF, iccG and iccH within the pathway have still to be determined (PubMed:30905148) (Probable).
What are the official names of this protein?
Trans-enoyl reductase iccB, Ilicicolin H biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: SYQ_PSESM
Sequence: MSKDPMSKPTPEPAAHSKAGPAVPTNFLRPIVQADLDSGKHSKIITRFPPEPNGYLHIGHAKSICVNFGLAKEFGGDTHLRFDDTNPAKEDQEYIDAIMNDVKWLGFEWAGEVRYASQYFDQLHDWAVELIKAGKAYVDDLTPEQAREYRGTLTEPGKNSPFRERSVEENIDLFARMKAGEFEDGARVLRAKIDMASPNMNLRDPILYRIRHAHHHQTGDKWCIYPIYDFTHGQSDAIEGITHSICTLEFESHRPLYDWFLDNLPVPCKPRQYEFSRLNLNYTITSKRKLKQLVDEKHVNGWDDPRMSTLSGFRRRGYTPKSIRNFCEMIGTNRSDGVVDFGMLEFSIRDDLDHSAPRAMCVLRPLKVVITNYPEGQVEKLELPRHPKEDLGMRELPFSREIYIDRDDYMEEPPKGYKRLEPNGEVRLRGSYVIRADEAIKDADGNIVELRCSYDPDTLGKNPEGRKVKGVVHWVPAAESVECEVRLYDRLFRSANPEKAEDGASFLDNINPDSLQVLTGCRAEPSLGHAQPEDRFQFEREGYFCADIKDSKPGQPVFNRTVTLRDSWT
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_CAMJR
Sequence: MRIAVIGAGKWGSALHLALKENHNCFISSLHQRDLEDFVSIKEALECEYLVFALSSQGMRAWLKENFINKGQKILIASKGIEDQSCQFLDEIFLDFVPKENFCVLSGPSFAAEVMQKLPTALMISGINQELCKKFASFFPDFIKTYIDNDVRGAEICGAYKNVLAIASGISDGLKLGNNARAALISRGLIEMHRFGKFFGTKEETFLGLSGAGDLFLTATSVLSRNYRVGLKLAQNQKLDSILAELNEVAEGVKTAYAIEKLAKMKGIYTPIVNEVVAIFKGKSVQEATQNLLKQND
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCH2_ARATH
Sequence: MVEDPIPLPNASMEVSYQNPIEAATIPVQIAVAEPVATPNPPPCLHENKFLVSVEVCLKPSSTARLEDVQRAVERMLENRSMSYADGLVLIPADDLFLVDNVQRICICDTEEWVKNNDVLLFWQVKPVVHTFQLIEEGPCEDLCADGQPASFNEWILPAKEFDGLWESLIYESGLKQRLLRYAASALLFTQKGVNPNLVSWNRIILLHGPPGTGKTSLCKALAQKLSIRCNSRYPHCQLIEVNAHSLFSKWFSESGKLVAKLFQKIQEMVEEDGNLVFVLIDEVESLAAARKAALSGSEPSDSIRVVNALLTQMDKLKSAPNVIILTTSNITTAIDVAFVDRADIKAYVGPPTLHVRYEILRSCVEELISKGIISSFQGCDGLSIPSFSSLKEKLSESEVHDTNTVPWFCKQLIEAAKGCEGLSGRSLRKLPFLAHAALADPYSHDPSNFLCTMIETAKREKSEQPE
What is the function of this protein?
Plays a key role in chromosome recombination during meiosis.  Mediates meiotic chromosome remodeling and crossover maturation.
What are the official names of this protein?
Pachytene checkpoint protein 2 homolog, AtPCH2.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. PCH2 subfamily.
What are the subcellular locations of this protein?
Chromosome. Note=Localizes to the sites of chromosome axis remodeling.
Protein: HSLV_METCA
Sequence: MENFHGTTIVSVRRGDQVVIGGDGQVTLGDTVMKGNARKVRRLYNGRVLAGFAGATADAFTLFERFESQLEKHRGNLTKAAVELVKDWRTDRMLRRLEALLAIADDKASLIISGNGDVIEPENGLIAIGSGGPFAQSAARALLENTELGARDIVEKSLIIAADICIYTNRNLTIEELETGRNFPNLA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_MANSM
Sequence: MIMWQSLILISSGAALGASLRWGMGLILNPLFAAFSFGTLIANYLGCFIIGLIMAMIWQHPQFSGEWRLFMITGFLGSLTTFSSFSAEVMENFIQQKWLIGLGIMSAHLFGCLIFTGIGVLITRWLN
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.