PharMolix/UniProtQA huggingface dataset:
Protein: CASPA_DANRE
Sequence: MAKSIKDHLQDALSNIGADNLRRFQSRLGDRKQEPRVRKSTIEKLKDEIDLVDLLVNTFTSDAVSVTVDILRGIKCNAVAEELLENTGQGGVSQPEPPVPEPIPKDPAQLKELKVTPCSQQFKNKILREKGQETYEIKDKSVRKRLALLINNVDFDDKAMKRSGSEKDEENMEKLLKELDYQVVKRPNLSAKEMDEAIRDFAQREEHKYSDSAFVVIMSHGKRDAIMGVHYHRTNNPSDSFPVDNVYRRLNSENCPALRDKPKVILIQACRGGEHGRVWASDGEPDEPIEIEDDDFVHKEKDFISLMSCTPDTKSYRHVQNGTFYVQTLVDVFIKCAHEDHIEELFRKVLRRFEHPNMIGNFKQMACKDRATLPKLFYLFPGL
What is the function of this protein?
Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis (PubMed:12464617, PubMed:30150286).  Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation (PubMed:30150286).  In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form (PubMed:30150286).  Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu (PubMed:30150286).  Required for the development of the cartilaginous pharyngeal skeleton (PubMed:12464617).
What are the official names of this protein?
Caspase a.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Inflammasome. Cytoplasm. Note=Co-localizes with pycard, nlrp1 and caspb in the cytoplasm (PubMed:30150286). Co-localizes with pycard at large cytoplasmic aggregates, known as specks (PubMed:12464617, PubMed:30150286).
Protein: PYRB_CYTH3
Sequence: MSQLSVKHLLGIKDLTTKDIELILETAGQFKEVINRPIKKVPSLRDVTIANVFFENSTRTRLSFELAQKRLSADTINFSAAASSVKKGETLLDTVNNILAMKVDMIVMRHASVGAPHFLAKHISANIVNAGDGTHEHPTQALLDSFSIKEKLGGVAGKKVCIFGDILHSRVALSNIFALQKQGAEVMVCGPSTLIPKFIGELGVKVEFDLRKALQWCDVANVLRIQLERQTIKYFPTLREYAQYYGINKQLLDSLNKEIVIMHPGPINRGVELSSDVADSGHSIILDQVENGVAVRMAVLYLLAGNK
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: MNMG_SALRD
Sequence: MHQDYFEHDVIVVGGGHSGSEAAAAAANMGADTLLITMKLADIGQMSCNPAIGGIGKGHIAREIDALGGIMGKATDRAGIQFRMLNKSKGPAVWGPRAQCGRRAYARAIRQELEAIDNLKMRSDMVKEILTDDAGETVTGVRTNLGKEFRAPCVVLTTGTFSNGVIHVGEQNFGGGRIGESASHGITGCLHDLGFESGRLKTGTPPRVDGRSIDYSVMEKQPGDPDATAFSFLTDDLPSVEAQLSCWLTDTTPETHEVLRTGFDRSPMFTGALDADGPRYCPSIEDKIDRFSEKDHHQLFIEPEGRDTHEVYVNGFSSSLPEEVQFEALRTVPGMEEAHMHRPGYAIEYDFFPPYQIEYSLETKYVDGLFFAGQINGTTGYEEAAAQGIMAGINAVQKLRQADPIVLKRSEAYIGVLIDDLVAKGTDEPYRMFTSRAEHRILLRQDNADQRLTELGHKLGLASKERLDRTREKERAIDVTRETLSDTTVSPQQVDDYLQSVGTSTLNQPRPVIELCKRPEVDSEDLLRHAGLYDEVVTEAPGMLSAPRLIEIDLKYEGYIDRQKDMVEEMEEKERWPIPDDFDYHALDNISIEARQKLSKVEPDNLGQASRVPGVRASDISVLMVLLKNEGVEPMPKDRDLNLDAMGGDGQSFGVSRETAVEVG
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMT2_OCIBA
Sequence: MSSTANNPQINSDEEENFLFAMQLASASVLPMVLKSAIELDLLELIKKAGAGAFVSPAELAAQLLTTNAEAHVMLDRILRLLTSYAILECRLKTLPDGGVQRLYGLAPVCKFLTKNEDGVSMAPLALMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNQGMSNHSTITMKKILETYTGFDGLKTVVDVGGGTGATLNMIISKYPSIKGINFDLPHVVEDAPSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDAHCVKFLKKCYEALPENGKVILAECVLPEAPDTGLATKNVVHIDVIMLAHNPGGKERTEKEFQVLAKASGFKQFNKVCCAYNSWIMELLK
What is the function of this protein?
Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid.  The resulting products may subsequently be converted to the corresponding alcohols that are incorporated into lignins.
What are the official names of this protein?
Caffeic acid 3-O-methyltransferase 2, CAOMT-2, COMT-2, S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: RPOA_PSEP1
Sequence: MQISVNEFLTPRHIDVQVVSPTRAKITLEPLERGFGHTLGNALRRILLSSMPGCAVVEAEIDGVLHEYSAIEGVQEDVIEILLNLKGLAIKLHGRDEVTLTLSKKGSGVVTAADIQLDHDVEIVNPDHVIANLASNGALNMKLTVARGRGYEPADSRQTDEDESRSIGRLQLDASFSPVRRIAYVVENARVEQRTNLDKLVIDLETNGTLDPEEAIRRAATILQQQLAAFVDLKGDSEPVVVEQEDEIDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLDNWPPASLKKDDKATA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: CLPP2_HALH5
Sequence: MNGYVPYVIEQSGLSERSYDIYSRLLKDRIVFLGAAIDDQIANSIVAQLLFLEAENPKKDIYLYINSPGGSTSAGFAIYDTMQFVKPSIHTICTGMAASFAAILLLAGTKGKRFALPNSEIMIHQPSGGAQGQASDLAITAKRILGIREKLVTVTSERTGQSPEKVAKDMDRDYFMSAEEALEYGIVDQIITSV
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
Protein: EIF3E_COCIM
Sequence: MADNAPPSADSAKTPEEIIKEYDLLPKLIPYLDRHLVFPLLEFASGQEETQESIDEITKSKYELLKQTNMTDYVANLWQEINHSDTIPEEFVKKREEVVQRLQQYVEDSSKITELLQDDNVVGNLRSDKVANLKFLEEQHGATVDMVNTLYDYGRFQYSCGSYGNAAELLYQFRVLSTDNDKVASATWGKLASEILTTNWEGAMEEVQKVKDSIDTRLFNNPLGQLQHRTWLIHWSLFPLFNHEPARDVLTDLFFSPAYINTIQTSCPWILRYLTAAVITNRQRVHKNSSLYQKQLKDLIRIVRQEEYEYQDPITDFIKALYIDFDFEEAQKKLGEAEEVLRSDFFLVAAADAFVESARHLISESYCKIHQRIDIKDLSTRLGLSQDEGEKWIVNLIRDTRVDAKIDYKEGTVLMNHPPQSVYQQVIEKTKGGFFRTQVLSAAVAK
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit E, eIF3e.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit E family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOW_DROME
Sequence: MSVCESKAVVQQQLQQHLQQQAAAAVVAVAQQQQAQAQAQAQAQAQQQQQAPQVVVPMTPQHLTPQQQQQSTQSIADYLAQLLKDRKQLAAFPNVFTHVERLLDEEIARVRASLFQINGVKKEPLTLPEPEGSVVTMNEKVYVPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDANRGKPNWEHLSDDLHVLITVEDTENRATVKLAQAVAEVQKLLVPQAEGEDELKKRQLMELAIINGTYRDTTAKSVAVCDEEWRRLVAASDSRLLTSTGLPGLAAQIRAPAAAPLGAPLILNPRMTVPTTAASILSAQAAPTAAFDQTGHGMIFAPYDYANYAALAGNPLLTEYADHSVGAIKQQRRLATNREHPYQRATVGVPAKPAGFIEIQ
What is the function of this protein?
Required for integrin-mediated cell-adhesion in wing blade.  Vital role in steroid regulation of muscle development and to control heart rate.  Required during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization.
What are the official names of this protein?
Protein held out wings, KH domain protein KH93F, Protein muscle-specific, Protein struthio, Protein wings held out, Putative RNA-binding protein, Quaking-related 93F.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS7_DESDA
Sequence: MPRKGPVPKREVLPDPIYSSRLITKFVNRLMYDGKKGAAEKIFYSSLEHLAEKTGEEPMRAFEKALDNVKPHMEVKARRVGGATYQVPMEVRPERQVSLSIRWLINYARSRGEKGMTAKLSAELLDAFNGRGGAVKKREDTHRMADANKAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: TMX2_PONAB
Sequence: MAVLAPLIALVYSVPRLSRWLAQPYYLLSALLSAAFLLVRKLPPLCHGLPTQREDGNPCDFDWREVEILMFLSAIVMMKNRRSITVEQHIGNIFMFSKVANAILFFRLDIRMGLLYITLCIVFLMTCEPPLYMGPEYIKYFNDKTIDEELERDKKVTWIVEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGKVDVGRYTDVSMRYKVSTSPLTKQLPTLILFQGGKEVMRRPQIDKKGRAVSWTFSEENVIREFNLNELYQRAKKPSKAGDSIPEEQPVASAPTTVSDGENKKDK
What is the function of this protein?
Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity.  Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
What are the official names of this protein?
Thioredoxin-related transmembrane protein 2, Thioredoxin domain-containing protein 14.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Mitochondrion membrane. Note=Localizes to endoplasmic reticulum mitochondria-associated membrane (MAMs) that connect the endoplasmic reticulum and the mitochondria.
Protein: PSBM_BIGNA
Sequence: MEVNILGVIAVALFILIPTSFLLILYVKTSAENKDN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MIAB_EHRCJ
Sequence: MKGLYIKSYGCQMNVYDSLIMENIIKPLGFTVVSEPSEADVVILNTCHIREKASEKLYSELGKIRKIQENKDLTIVVAGCVAQAEGEEIFERSPFVDIVVGPQSIHTLPELLVKAHRIKKQVINIDFPVISKFDAIPVEEYTKNQETSAFISVQEGCNKFCTFCVVPYTRGEEYSRTVEAIFNEALVLADSGIKEITLIGQNVNAYHGTYKGCEWDLGKLIQHIAKIPNIERIRYTTSHPRDMHQSLYEAHKLEEKLMPFVHLPVQSGSDRILKKMNRKHTAEEYIDIISHLRKQRPDIAFSSDFIVGFPGETEEDFENTIKLVEKVKFSQAYSFKYSPRPGTPGAEYPNQVPEEIKSERLLRLQKLLREQQLAFNRSMIGETCTVLFSSKKGKFDNQIIGKTAYMQSCYINTDNPSQFYNSISPIKIIDAHQNSLTGVVC
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YABA_ANOFW
Sequence: MNKKEIFQSVTSIEEQIAHLYKQLGELKSYLGELIEENHRLQVENDHLRRRLEQLSERKVEQGKKQTKAKLVDIGEGYDNLARLYQEGFHICNVHYGSLRTDGDCLFCLSFLNKK
What is the function of this protein?
Involved in initiation control of chromosome replication.
What are the official names of this protein?
Initiation-control protein YabA.
What is the protein family that this protein belongs to?
Belongs to the YabA family.
Protein: RM44_PONAB
Sequence: MASGLVRLLQQGPRCLLAPVAPKLVPPVRGVKRGFRAAFRFQKELERQRLLRCPPPPVRRSEKPNWDYHAEIQAFGHRLQENFSLDLLKTAFVNSCYIKSEEAKRQQLGIEKEAVLLNLKSNQELSEQGTSFSQTCLTQFLEDEYPDLPTEGIKNLVEFLTGEDVVCHVARNLAVEQLTLSEEFPVPPTVLQQTFFAVIGALLQSSGPERTALFIRDFLITQMTGKELFEMWKIINPMGLLVEELKKRNISAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKLYGFTENRRPWNYSKPKETLRAEKSITAS
What is the function of this protein?
Component of the 39S subunit of mitochondrial ribosome.  May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.
What are the official names of this protein?
39S ribosomal protein L44, mitochondrial, L44mt, MRP-L44.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RIBBA_CORGL
Sequence: MSEHEQAHSQLDSVEEAIADIAAGKAVVVVDDEDRENEGDIIFAAELATPELVAFMVRYSSGYICAPLTAKDADRLDLPPMTAHNQDARGTAYTVTVDANTGTTGISATDRAHTLRLLADPEADRTDFTRPGHVVPLRAREGGVLVRAGHTEAAVDLARAAGLRPAGVICEVVSEEDPTGMARVPELRRFCDEHDLKLISIEQLIEWRRKNEILVERQVETVLPTDFGTFKAVGYRSIIDGTELVAIVAGDVASDGGENVLVRVHSECLTGDVFGSRRCDCGQQLHESLRLIQEAGRGVVVYMRGHEGRGIGLLAKLRAYQLQDEGADTVDANLALGLPADAREFGTSAQILYDLGVRSLNLISNNPAKKVGLEGHGISIASRTPIPVAVHEDNVRYLKTKRDRMGHDLPDVALWEQEHPEN
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: RL33_ECOUT
Sequence: MAKGIREKIKLVSSAGTGHFYTTTKNKRTKPEKLELKKFDPVVRQHVIYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RL28_SALPK
Sequence: MSRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVESEKRFVTLRVSAKGMRIIDKKGIETVLSELRARGEKY
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: SYE1_GLUDA
Sequence: MTVRTRFAPSPTGLLHIGNARAALFNFLYARHHGGKFLLRIEDTDRERSTQQAVDVLFDGLAWMGITPDEEPVFQSTRQARHAEIAHHLLAQGLAYRCYCTPEELQQMRDQAAAEGRPPRYNGYWRDRDPSEAPAGAPYTVRIRAPREGETVIHDLVQGDVRVANAELDDMIILRGDGTPVYQLAVVVDDHDMDITHVIRGDDHLTNTFRQAMIYRAMGWDLPAFAHLPLIHGPDGAKLSKRHGAQSVVEFREMGYLPEALNNYLLRLGWGHGDAEILSRDEQIQLFDLDGVGRSASRMDYVKLQHLNGVWLRQADDARLTDDIVARLADRPDVSVDEAVRARILALMPGLKERAKTLVDLADSAAFLGRHVPLAFDAKAEKLLTPEARAMLGELARDLAVIEPFDAPAIDVALRRFAEHHGHKLGQVAQPLRAAMTGGATSPGIDATLAALGRDEVMARIGAVAR
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_RHYRA
Sequence: MTNLRKNHPLMKIVNDAFIDLPAPSNISAWWNFGSLLGICLVLQILTGLFLAMHYISDTTMAFSSVAHICRDVNYGWLIRNMHANGASMFFMCLYLHIGRGIYYGSYLYKETWNIGVILLFTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKSTLTRFFAFHFILPFVILALAIVHLLFLHETGSNNPSGINPDSDKIPFHPYYTIKDILGLSLMILVLLLLAMFSPDMLGDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLAIPLLHTSNQRSLMFRPISQTLFWILTADLFVLTWIGGQPVEQPYIIIGQTASILYFMIIIILMPMAGLFEKYMLKPKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL6_STAAE
Sequence: MSRVGKKIIDIPSDVTVTFDGNHVTVKGPKGELSRTLNERMTFKQEENTIEVVRPSDSKEDRTNHGTTRALLNNMVQGVSQGYVKVLELVGVGYRAQMQGKDLILNVGYSHPVEIKAEENITFSVEKNTVVKVEGISKEQVGALASNIRSVRPPEPYKGKGIRYQGEYVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: DIAA_YERPY
Sequence: MLERIKGCFTESIQTQIAAAEALPDAISCAAMALVQSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNADNVVLTAITNDRLHDEVYAKQVRALGQAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGQLDVEIRIPSHRGARVQELHMLTVNCLCDLIDNTLFPHQDD
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: THOC5_CHICK
Sequence: MSSDSKKRKPKVIRTDGGPQEGKRGKADGEQDARYYSEECEVDLRDPIKDYELYKETCQELQRLMAEIQELKSRGVKDNASEIDERRVQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIELVSLEEFYSEAPTEISRPDITLTEPHQQTLARLDWELEQRKRLAERYKECQTIKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQASAYGQACDKKLVVAIEGSVEEAKALYKPPEDSQDDESDSDMEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVTVDLKCKDENVLHLTFYYLMNLNIMTVLHLTFYYLMNLNIMTVKTKVTTAAELTTAISAGDLLSPDSLLSCLYPGDHGKKTPNPANQFQFDKVGILTLSDYVTELGHPYVWVQKLGGLHFPKDQPQHTVTADNSLSASHMEMTMKLLRTRLQSRLALHKQFASLEHGVVPVSSECQHLFPTKIVSRLVKWTAIPFEDYTELPYTKDVVEAGLAEDTHLYYMALIERGTAKLQAAVVLNPGYSALPPIFSLCLNWKGERTGSNDDNIRAMESEVNVCYKELWGPKPGYQLLTNQLQRLCMVLDVYLETEPHDTTVEGPKEFPQEKMCLRLVRGPMRLKPFKFNYPQGFFSHR
What is the function of this protein?
May be involved in cell differentiation.
What are the official names of this protein?
THO complex subunit 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the THOC5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.
Protein: IF4E_XENLA
Sequence: MAAVEPENTNPQSTEEEKETGQEIVSPDQYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMSGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRNDLDRFWLETLMCLIGESFDEHSDDVCGAVVNVRAKGDKIAIWTTEFENKDAVTHIGRVYKERLGLPAKVVIGYQSHADTATKSGSTTKNRFVV
What is the function of this protein?
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:10635326).  In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (By similarity).  Maternal RNA in oocytes remain in a dormant state as tacc3/maskin outcompetes eif4g to bind eif4e, thereby preventing translation (PubMed:10635326).  During oocyte maturation this complex dissolves and eif4g binds eif4e to allow translation of maternal RNAs (PubMed:10635326).
What are the official names of this protein?
Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
What are the subcellular locations of this protein?
Cytoplasm. Note=When interacting with tacc3/maskin.
Protein: RSMG_BURM7
Sequence: MQQRRRPPIASRETLQALLSEGAQALGVALSDAQRGALLDYVALLAKWNAVYNLTAIRDPRQMLIQHILDSLSIVPHLGAHGAAAAALDVGSGGGLPGVVLAIALPGWRVTLNDIVHKKSAFQNQAKAELKLGNLSVVTGRVETLRPGADVPAKFDVIVSRAFADLADFVTLARHLVAPGGSIWAMKGVRPDEEIGRLPDGARVKQMIRLTVPSLDAERHLIEVELDEAI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDH_BACCA
Sequence: MKNGRGNRVAVVGTGFVGASYAFALMNQGIADEIVLIDANENKAEGDAMDLNHGKVFAPKPADIWHGDYDDCRDADLVVICAGANQKPGETRLDLVDKNIAIFRSIVESVMASGFQGLFLVATNPVDILTYATWKFSSLPQERVIGSGTILDTARFRFLLGDYFAVAPTNVHAYIIGEHGDTELPVWSQADIGGVPIRKLVESKGEEAQKELERIFVNVRDAAYQIIEKKGATYYGIAMGLARVTRAILHHENAILTVSAYLDGPYGERDVYIGVPAVINRNGIREVIEIELDEEEKKWFHRSAATLKGVLARYFAQ
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ULAE_SALEP
Sequence: MLSKQIPLGIYEKALPAGECWLERLRLAKTLGFDFVEMSVDETDARLARLDWSREQRLALVSAVAETGVRVPSMCLSAHRRFPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQQANDETRCRFRDGLKESVDMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAENPAAEVAKARDWVKARMASAGLVEAA
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 3-epimerase UlaE, L-ascorbate utilization protein E, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.
Protein: DNLJ_BURL3
Sequence: MARTQAEPPASQPDARAAWLRDQLERANYAYYVLDQPDLPDAEYDRLFRELQQLETDHPELVTPDSPTQRVGGEAAGGFTPVVHDAPMLSLNNGFADEDIAAFDKRVADALDKTTDLAGSVTEPVEYACELKFDGLAISLRYEQGVFVQASTRGDGTTGEDVTENVRTIRSIPLKLKGKHVPAVLDVRGEVLMFKRDFARLNERQRAAEQREFANPRNAAAGSLRQLDSKITAQRPLSFFAYGIGVLDGMPMLDTHSALLDWYESLGLPVNREREVVQGAEGLLGFFRKIGEKRESLPYDIDGVVYKVNRRDEQERLGFVSRAPRFALAHKFPAQEALTKLVAIDVQVGRTGAITPVARLEPVFVGGATVTNATLHNEDEVRRKDIRIGDTVIVRRAGDVIPEVVGALLDRRPADAAEFVMPTECPVCGSKIERLPDEAIARCTGGLFCPAQRKQALWHFAQRRALDIDGLGEKIIDQLVELNLVRTPADLFNLGFATLAELDRFAEKSAQNLLDSLEKAKHTTLARFIYGLGIRHVGESTAKDLAKHFGSLTPIMDASIEELLEVNDVGPIVAESLHQFFAEEHNRTVIEQLRAPGKVTWPEGPPAPKAPQGVLAGKTVVLTGTLPTLTRDAAKEMLEAAGAKVAGSVSKKTDYVVAGAEAGSKLVKAEELGIPVLDEDGLHQLLEGNTP
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RL33_BORPA
Sequence: MAKGIREKIKLESTAGTGHFYTTTKNKRNMPEKMLIKKFDPVARKHVDYKETKLK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.