PharMolix/UniProtQA huggingface dataset:
Protein: PG117_VACCW
Sequence: MDAAIRGNDVIFVLKTIGVPSACRQNEDPRFVEAFKCDELERYIENNPECTLFESLRDEEAYSIVRIFMDVDLDACLDEIDYLTAIQDFIIEVSNCVARFAFTECGAIHENVIKSMRSNFSLTKSTNRDKTSFHIIFLDTYTTMDTLIAMKRTLLELSRSSENPLTRSIDTAVYRRKTTLRVVGTRKNPNCDTIHVMQPPHDNIEDYLFTYVDMNNNSYYFSLQQRLEDLVPDKLWEPGFISFEDAIKRVSKIFINSIINFNDLDENNFTTVPLVIDYVTPCALCKKRSHKHPHQLSLENGAIRIYKTGNPHSCKVKIVPLDGNKLFNIAQRILDTNSVLLTERGDHIVWINNSWKFNSEEPLITKLILSIRHQLPKEYSSELLCPRKRKTVEANIRDMLVDSVETDTYPDKLPFKNGVLDLVDGMFYSGDDAKKYTCTVSTGFKFDDTKFVEDSPEMEELMNIINDIQPLTDENKKNRELYEKTLSSCLCGATKGCLTFFFGETATGKSTTKRLLKSAIGDLFVETGQTILTDVLDKGPNPFIANMHLKRSVFCSELPDFACSGSKKIRSDNIKKLTEPCVIGRPCFSNKINNRNHATIIIDTNYKPVFDRIDNALMRRIAVVRFRTHFSQPSGREAAENNDAYDKVKLLDEGLDGKIQNNRYRFAFLYLLVKWYRKYHVPIMKLYPTPEEIPDFAFYLKIGTLLVSSSVKHIPLMTDLSKKGYILYDNVVTLPLTTFQQKISKYFNSRLFGHDIESFINRHKKFANVSDEYLQYIFIEDISSP
What is the function of this protein?
Multifunctional protein required for genome uncoating and replication (PubMed:18000036, PubMed:17093187, PubMed:26912611).  Major viral uncoating protein that is required for the release of the viral genome from incoming viral cores containing the viral DNA genome (PubMed:24439902).  Possesses an ATPase activity that is required for hexamerization and uncoating (PubMed:24439902, PubMed:26912611).
What are the official names of this protein?
Uncoating factor OPG117.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG117 family.
Protein: R1B23_SOLDE
Sequence: MIEFWKSEYTRILSICHDSGTQYRNKNVRMRSLYLEKVWVAFKSFAYWKEVIWKTKQEFRAQYSFPKTSLEANKVDDANTHSPKFVMEVIDVFVENLNDLMKINDPSSWLFVPGHMKEQIEKVLKELKLLRFFVCFVSNKCIQPQYQHTTFYTHALIEASHNAMVVWLHLPVYGIGNQDLAPSEVSRLLSDFMEMKIKSIQPGISRNSIYIDVLQALKSTIPQAQQKHVAESGIVEIPTHSLTVGLSDQMANLQEMLCLLRDNLIHLPILDLEFHLQDMDSVIVDAGLLIYSLYDIKGEKEDTILEDIKRELGFDLPRNIEPIKVMVYLVMQKAFQCNLPRIHGLGYVDFLLKNLKDFQGRYSDSLAFLKNQLQVIQTKFESMQPFLKVVVEEPHNKLKTLNEDCATQIIRKAYEVEYVVDACINKEVPQWCIERWLLDIIEEITCIKEKIQEKNTVEDTMKSVIASSQLARTPRMNEEIVGFEDVIETLRKKLLNGTKGQDVISMHGMPGLGKTTLANRLYSDRSVVSQFDICAQCCVSQVYSYKDLLLALLRDAIGEGSVRTELHANELADMLRKTLLPRRYLILVDDVWENSVWDDLSGCFPDVNNRSRIILTTRHHEVAKYASVHSDPLHLRMFDEVESWKLLEKKVFGEESCSPLLRDIGQRIAKMCGQLPLSIVLVAGILSEMEKEVECWEQVANNLGTHIHNDSRAVVDQSYHVLPCHLKSCFLYFGAFLEDRVIDIPRLIRLWISESFIKSCEGRSLEDIAEGYLENLIGRNLVMVTQRDDSDGKVKACRLHDVLLDFCKERAAEENFLLWINRDQITKPSSCVYSHNQHAHLAFTDMKNLVEWSASCSCVGSVLFKNYDPYFAGRPLSSHAFSISRILLNFKFLKVLDLEHQVVIDSIPTELFYLRYISAHIEQNSIPSSISNLWNLETLILNRTSAATGKTLLLPSTVWDMVKLRHLHIPKFSPENKKALLENSARLDDLETLFNPYFTRVEDAELMLRKTPNLRKLICEVQCLEYPHQYHVLNFPIRLEMLKLHQSNIFKPISFCISAPNLKYLELSGFYLDSQYLSETADHLKHLEVLKLYYVEFGDHREWKVSNGMFPQLKILKLKCVSLLKWIVADDAFPNLEQLVLRRCRHLMEIPSCFMDILSLQYIEVENCNESVVKSAMNIQETQVEDNQNTNFKLVLIEIHLFCLFDMKGIESISTDMKEKKLTVTRDVDADEVQLVVEKLRNVAYADEVQLVVEKLRKRGML
What is the function of this protein?
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1.  Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein.  That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
What are the official names of this protein?
Putative late blight resistance protein homolog R1B-23.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: EFP_CLOB1
Sequence: MISAGDLRKGTTFEQDGQVYVVVEFLHVKPGKGAAFVRTKLKNAITGAVTETTFNPTAKLQEAVIERKEMQYLYTDGELYYFMDQETFEQIPLNYDKVEEAIKFLKENMFATIKFFKGEAFSVEAPNFVELLISHTEPGAKGNTTSNVMKPATLETGATIQVPLFVNEGETIRVDTRTGEYMERV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MON1_CRYNJ
Sequence: MTSESEPNTSLPFSPIQQTLPATPSRSTSQVSMVSAEALLSHSSPTKQLTPSHRSSLPSALPYNTLLNAPAGSPALRARASTASSSRAPSVLDDARVEHNDSETQVLEITPPMDNYELDGGSDHTSLPSDASSIKGKEKQRSNDRNEIETVGAGGEMALPSGDARKGLKELVRRSTTADKGYGGHDHRRLSEKLSQNENLQILITQSDKMSYSPRLYYVLTNAGKPVFCSHTRPSEDDVTNLMGVAQALISIFADDDDRLRYIIKGNHRVAFLLKAPLYLFCVSDWGEPEHVLRLQLEYIHLQILSVVSSTQLLRLFQRRSNADLSTLLEGTEPFLSNLIDCSQYDFSFLTSTLQPLRMAPALRDTSAAALMPPSKFKDLLYVLLIAGGHIVTVLRPRKHSIHPSDLHLLLNTIASSSALRTTETWLPICFPKFNPSGFVHAYISYVLEDVGLVFVSADREAFEDLRVWKDMVLEKLEQDKTLSRIQEAIPLHPYTISSVGCPGLRHFIYKSRQHVQITQPIWEAPYEDGSTNQKRLVTTYQKLHDAVHAKSGQASALKLVYISTEHEACLVWATKPFELYITVSPQLSKSAVVAAANNVAKWVLAEEGRIFLKDAPVF
What is the function of this protein?
Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
What are the official names of this protein?
Vacuolar fusion protein MON1.
What is the protein family that this protein belongs to?
Belongs to the MON1/SAND family.
What are the subcellular locations of this protein?
Endosome, multivesicular body membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Protein: PRMA_STAAC
Sequence: MNWTELSIIINHEAVELATNILENHGSNGVVIEDSDGLINQPEDKYGEIYALKKEDYPDKGVRLKAYFNEMTYDDKLRQQIKDELLNLDELDQHNVQFSEQIIAETDWENEWKNYFHPFRASKKFTIVPSWETYAKEADEELCIELDPGMAFGTGDHPTTSMCLKAIETYVLPQHSVIDVGTGSGILSIASHLIGVKRIKALDIDEMAVSVAKENFRRNHCETLIEAVPGNLLKDETEKFDIVIANILAHIIDEMIEDAYNTLNEGGYFITSGIIKEKYEGIQSHMERVGFKIISEQHDNGWVCLVGQKVSE
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC15_CLITE
Sequence: GLPICGETCFKTKCYTKGCSCSYPVCKRN
What is the function of this protein?
Probably participates in a plant defense mechanism.  Active against Gram-negative bacterium E. coli ATCC 700926 (MIC=0. 5 uM) under low-salt conditions (PubMed:27007913).  Not active against Gram-positive bacterium S. aureus ATCC 12600 up to a concentration of 100 uM under low-salt conditions (PubMed:27007913).
What are the official names of this protein?
Cliotide T15, Cyclotide cT15.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebius subfamily.
Protein: RL39_PYRIL
Sequence: MARNKPLGKKLRLAAALKSNRNPPVWVVVKTKRRVTRSPTRRHWRRTKLKA
What are the official names of this protein?
50S ribosomal protein L39e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: FLIW_SULDN
Sequence: MKFDVCVPILGFENVKEVTLEKIDDAFMRMESSNDEHISFTLINPFALREYDFEIPDATQKLLEIDEKSNILILNIAIIQTPVEDTVVNFIGPMIFNTDNNKAAQLVLSESTKYGVAEKISLYLKK
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_STRP3
Sequence: MIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAEGYPGNRYYGGTECVDIVETLAIERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDADTEMLNYEAILEQAKAVQPKLIVAGASAYSRNIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGGLILTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHVFLVDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFNTSGIRIGCAAITSRGMGVKESQTIARLIIKALVNHDQETILEEVRQEVRQLTDAFPLYKK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMERL_ARATH
Sequence: MVSANREMAVYCFDTLVSHYNNEETPPPAFEEANHPLFVTWKKIVNGGEPRLRGCIGTLEARRLISGFKDYALTSALRDRRFPPIQAKELPSLQCTVSVLTDYEDAEDYLDWEVGKHGIIIEFTEPETNTKRSATYLPEVPAHEGWTKIEAIDSLVRKAGYNGVITEAVRRRINLTRYQSTLFSMHYSEYLSYVKATRGVVGPVINGINKHAFA
What are the official names of this protein?
Uncharacterized protein At2g38710.
Protein: YIDC_SHESR
Sequence: MESQRNILLIGLLFVSFLLWQQWQADKAPKPVATESSVVANATTNHSADVPEADTGVPAAMTATQNLITVKTDQLDVQINPVGGDIVFAALVSHKLEQGKDQPFVLLEQTKDFTYIAQSGLIGRDGIDSSAKGRAAFAASKTEFTLADGQDTLEVPLTYVADNGVTYTKVFVFHRGKFNVDIDYKINNTSAAPLQVQMYGQIKQTIKPSESSMMMPTYRGAAFSTQDVRYEKYKFEDMSKSNLNQPTLGGWAAMLQHYFVSAWIPPATDSNTIFSSVSAGGLANIGFRGAVYDIAPGATQEISSQFYVGPKDQKALSALSDTLNLVVDYGFLWWLAVPIHWLLMFYQSFVGNWGVAIILITLTVRGLLFPLTKAQYTSMAKMRNLQPKLQDLKERFGDDRQKMGQAMMELYKKEKVNPMGGCLPILLQMPIFIALYWVLLESFELRHAPFMLWIHDLSVQDPYYILPLLMGVSMFVMQKMQPIAPTMDPMQVKMMQWMPVIFTVFFLWFPSGLVLYWLVGNIVAIIQQKIIYAGLEKKGLK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACTP_ECO27
Sequence: MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSEAMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATEREELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMLGGWLGLITAVVLMILGPTIWVQILGHEKAIFPYEYPALFSISVAFLGIWLFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y767_VESOH
Sequence: MIDEALLKLLVCPKSKAPLKQVGNELICEVSGLAYPIEDGIPILLVEEARELDKGSDKK
What are the official names of this protein?
UPF0434 protein COSY_0767.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: RL36_BORBU
Sequence: MKVRVSVKPICEKCKVIKRKGVLRIICDNLKHKQRQK
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: RS8_WOLWR
Sequence: MALSDSIGDFLTRIRNAQLAMHRATRVLFSKMNSSILEILKEEGYILDYEKQVVDNLPSFIVKLKYYEKSPVISDIVRVSKPGCRRYSKYKDISKAYNGLGIFIISTPKGVMTDYNAHKLKVGGEVLCRVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ACHAB_XENLA
Sequence: MDYTASCLIFLFIAAGTVFGTDHETRLIGDLFANYNKVVRPVETYKDQVVVTVGLQLIQLINVDEVNQIVSTNIRLKQQWRDVNLKWDPAKYGGVKKIRIPSSDVWSPDLVLYNNADGDFAISKDTKILLEYTGKITWTPPAIFKSYCEIIVTYFPFDQQNCSMKFGTWTYDGSLLVINPERDRPDLSNFMASGEWMMKDYRCWKHWVYYTCCPDKPYLDITYHFVLQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHTMPPWVRKIFIETIPNIMFFSTMKRPSQEKQPQKTFAEEMDISHISGKLGPAAVTYQSPALKNPDVKSAIEGIKYIAETMKSDQESNKASEEWKFVAMVLDHILLAVFMTVCVIGTLAVFAGRIIEMNMQE
What is the function of this protein?
Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit alpha-1-B.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: NHAA1_CAMJ8
Sequence: MNNIVHKLKTLVLNEAFGGVLLIVCTLLALLVQNGSFSEHYREFLNLKVGFSVGEFELNKPFLLWINDGLISIFFFAIGLELKKEFLHGDFKNPKNIVLPFMAALGGILIPAMLFALVNIGDAYTLKGWAIPTATDTAFALAILMMCGKHIPSSLKIFLLSLAIFDDVGAILIIAIFYTTKLSIVAFVVAGIAILAMLVLNILGITRKSFYFICSVILWISVLKSGVHATLAGIITAFFIPMQTKNGEAFLEEIYESLKFWLAFVILPLFAFANAGVNLSNIDIGAIFSGVSVGIFLGLFVGKQVGVFLFSYLAIRFKFAALPQGSNLKQLYGVCILTGIGFTMSLFIDGLAYEVSDIFNYADNLAILIASFCSGIWGFIYLKFFAARS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 1, Sodium/proton antiporter NhaA 1.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AA2BR_CANLF
Sequence: MQLETQDALYVALELAIAALSVAGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFMVACKQLQRTELVDHSRTVIQREIHAAKSLAMIVGIFALCWLPVHAINCVTLFQPARAKDKPKWAMNMAILLSHASSVVNPIVYAYRNRDFRYTFHKIISRYVLCQTDVLKSGNGQAGTQSALDVGL
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
What are the official names of this protein?
Adenosine receptor A2b.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RBS3_FLAPR
Sequence: MASIPATVATVAQANMVAPFTGLKSNAAFPVTKKVNDFSTLPSNGGRVQCMKVWPPLGKKRYETLSYLPNLTESQLAKEVDYLLRNKWVPCLEFELEHGFVYRENARSPGYYDGRYWTMWKLPMFGCTDSAQVMKELQECKKEYPQAWIRIIGFDNVRQVQCISFIASKPDGF
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic 3, RuBisCO small subunit 3.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IF2GL_HUMAN
Sequence: MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYQLDDPSCPRPECYRSCGSSMPDEFPTDIPGTKGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKERQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQETEVRPGIVSKDSEGKLMCKSIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQILGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD
What is the function of this protein?
As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis.  In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation.  The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing.  This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP.  Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome.  In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity).  Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 2 subunit 3B, Eukaryotic translation initiation factor 2 subunit gamma A, eIF-2-gamma A, eIF-2gA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: ATP6_CROS8
Sequence: MSAGEISTPQEYIGHHLNNLQIDLRTFSLVDPHNPPATFWTLNIDSMFFSVVLGLLFLVLFRKVAKHATSGVPGKFQTAVELVIGFVHGSVQDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIGEHVFGLPALRVVPSADVNITLSMALGVFILILFYSIKMKGVGGFTKELTLQPFNHPVFIPINLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLNVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COAD_PORG3
Sequence: MKKNIALFAGSFDPFTRGHADIVERSLAIFDEVIIAIGINEQKRTLFSAERRQEQIARYYASRPAIGVITYSGLTVDLVRQTGATALVRGIRSGSDFEYERTLADLNRHLSGVDTVLLCTDTRLSFISSSAVRELISFGRDVSDFLPEGFVLD
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_BURTA
Sequence: MSMSDPIADMLTRIRNAQMVEKVSVSMPSSKVKVAIAQVLKDEGYIDDFAVKADGAKAELNIALKYYAGRPVIERLERVSKPGLRVYRGRNEIPQVMNGLGVAIVSTPKGVMTDRKARATGVGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: CIPKW_ORYSJ
Sequence: MSTTKVKRRVGKYELGRTIGEGTFAKVKFARDTETGDPVAIKILDKEKVLKHKMVEQIKREISTMKLIKHPNVVRIYEVMGSKTKIYIVLEYVTGGELFDTIVNHGRMREDEARRYFQQLINAVDYCHSRGVYHRDLKPENLLLDSYGNLKVSDFGLSALSQQIKDDGLLHTTCGTPNYVAPEVLEDQGYDGAMADLWSCGVILFVLLAGYLPFEDSNLMTLYKKISNAEFTFPPWTSFPAKRLLTRILDPNPMTRVTIPEILEDEWFKKGYKRPEFDEKYDTTLDDVYAVFNDSEEHHVTEKKEEPEALNAFELISMSAGLNLGNLFDSEQEFKRETRFTSKCPPKEIVRKIEEAAKPLGFDVQKKNYKLRLEKVKAGRKGNLNVATEILQVAPSLHMVEVRKAKGDTLEFHKFYKNLSRTLKDVVWKSDDLQNQLS
What is the function of this protein?
CIPK serine-threonine protein kinases interact with CBL proteins.  Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity).
What are the official names of this protein?
CBL-interacting protein kinase 32, OsCIPK32.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Protein: GL_EBVG
Sequence: MRAVGVFLATCLVTIFVLPTWGNWAYPCCHVTQLRAQHLLALENISDIYLVSNQTCDGFSLASLNSPKNGSNQLVISRCANGLNVVSFFISILKRSSSALTSHLRELLTTLESLYGSFSVEDLFGANLNRYAWHRGG
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Acts as a functional inhibitor of gH and maintains gH in an inhibited form.  Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.  The heterodimer gH/gL targets also host EPHA2 to promote viral entry.
What are the official names of this protein?
Envelope glycoprotein L, gL.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein L family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans- Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans- Golgi where secondary envelopment occurs.
Protein: COFD_METM5
Sequence: MNITILSGGTGTPKLIQGFKEIIPNEDISVIVNTGEDTYIGDIYLSPDIDTVLYTFSDLINDETWYGLKGDTFICHEQLKKFGFDEVLKIGDKDRALKMHKASSLKNGVPMSEIVDIERKSLSLKSKIYPMSNERVESKVLIEENNEKILLKFHDFWIFRKGNAKVLDIFYENSNYAKAADGVIKAIEESDFILIGPSNPITSIGPILSISEIKNALKEKLVFAVSPIVGENPVSGPAGTLMNAKGYPVSAVGVYEYYKDIVDVLVLDNSDINKKKDINCEVLYANTIMKTIDDKITLARNILDYYKSR
What is the function of this protein?
Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
What are the official names of this protein?
2-phospho-L-lactate transferase.
What is the protein family that this protein belongs to?
Belongs to the CofD family.