PharMolix/UniProtQA huggingface dataset:
Protein: MLTF_SHESH
Sequence: MKKLLFVLLTITLLASCQKVSVEQTKVIPEPIKKTTLNVGTLYGAQIFVTTGQGEAGFDFEMASRFAEYLKLELKMKPYSNISELYQALESGEVDLLAAGLADTPTRREKFRLGPPLYRVNQVLVYKQGTPIPKDVSTLEDNITVITDSSFVETLSQLQKLYPELVWEQEKEKDSEELMAMIARGEITYTIADSSTFEINRRYLPELRAGPILKEKQAIVWLLPPKNSDQLMSDLLTFWHYEKRSGTLAHLNEKYFAHVKRFDYVDTRAFLRAIDNKLPKYKESFQHYANGIDWRKLAATAYQESHWNPNARSPTGVRGLMMLTLPTAKQVGIKNRLDPIQSIKGGAKYLNDILNRLPDSIPENQRMWFALASYNIGYGHVEDARKLAQSMGLNPSAWRDLKEVLPLLHKRKYYQRTRYGYARGNEAVHYVDSIRRYYDTLVWVDNQNQLLIDEKASAEESQLAEKIGGKQENLSGAQPQ
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: Y1632_METJA
Sequence: MLNTLMLREWLRSMLRSCISKIFGDLMLISHISLSDKITLLTYGCNFKCKYCFFKPLSCKKYSVDEILNKILEVNENYKLDKILIAGGEPTLQNDLSELTKLLKDEGFYLMLSTNGYYLKDMLDKLEVDEIHIDLKAYDENKHIYLTSCSNKKVLDCISYIGKYRDEFNFKVEIDTVLIPNIVDLDEIEKIAKFLSNWDLPYRITGYVKYNNNLNAEKPDEDKILKAKEIALKYLSNVSCSLDFKRHKKSKKVII
What are the official names of this protein?
Putative glycyl-radical enzyme activating enzyme MJ1632, GRE activating enzyme MJ1632.
What is the protein family that this protein belongs to?
Belongs to the organic radical-activating enzymes family.
Protein: RS20_EHRCR
Sequence: MANHPSAKKMIKVIKKRTMVNRMRKSRAHNYVKKFMAALAAGNKELMIETFKKAESNLHKCVNKKIIHRNTAARKISRMALKLKAFDLQQQAKAV
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: MURD_DESRM
Sequence: MNFLGKRVLVVGAGLSGQAVCKFLQEKQSVVTLTDTRTREQIGQAIVQLSELGIELILGEYPSVDKGQYDMLVMSPGVPLTILPVVQAKKFDIPVLGELELAYRFAKAPIVAITGTNGKTTTTTLTGQLFRDAGFKTLVAGNIGLPMVSEIENYQVGDIVVAEVSSFQLETTEYFAPKVAVMLNLTPDHLDRHGSMEEYIKAKSCIFIHQKPSDYVVLNYDDLALRELAKSCPSQVIFFSRQHIIEKGSFIQNDKIMVSGKGGPEEVIDVNALRIPGPHNLENALAATAAAYTLGLSPRDIAGTLGRFTGVAHRLEFVANINGVEYVNDSKGTNPDAAIKALESYDAPIILIAGGKNKGISFNDFAKKIKEKVRVLITLGVHGYQIEEAAREQGFTNIYPVEDYAQAVQLARKQAKPGEIVLLSPACTSWDMFKSFEERGELFKKLVLEMQKNESF
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSK1_TOBAC
Sequence: MTSVGLAPVSGLRESSSHSVGVDRLPEEMNDMRIRDDKEIEAAIVDGNGTETGHIIVTTIGGRHGQPKQTISYMAERIVGQGSFGVVFQAKCLETGETVAIKKVLQDKRYKNRELQTMRLLDHPNVVCLKHCFFSTTEKDEVYLNLVLEYVPETVHRVIKHYNKLNQRMPLILVKLYTYQIFRALSYIHHTIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDIWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYNEFKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRCTALEAVTHAFFDELRDPNTRLPNGRVLPPLFNFKAHELKGVSAENLLKLVPEHARKQCPSLGL
What is the function of this protein?
May mediate extracellular signals to regulate transcription in differentiating cells.
What are the official names of this protein?
Shaggy-related protein kinase NtK-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Protein: NPD_VIBVU
Sequence: MNFPYRNIVVLTGAGISAESGIQTFRAQDGLWENHRIEDVATPEGFARDPDLVQDFYNQRRKKLQDPNIEPNAAHLALGRLEAELDGQVTIVTQNIDNLHERGGNKNIIHMHGELLKSRCSVSNQVIEETGDILTGDLCHCCQMPSQMRPHVVWFGEMPLRMGEIYSALETADLFISIGTSGVVYPAAGFVHDAKMHGAHTIEINLEPSAIESEFVEKRYGKASVEVPKLVEELLAHLESNVESA
What is the function of this protein?
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins.  Modulates the activities of several proteins which are inactive in their acylated form.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNB_YERPA
Sequence: MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRIIATLHTDKDREIAEPETLVEPFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTHSFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVPWWVTLARHNLEREAPAMVESALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSELDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRPVLVCRVTITEEGTLSNDIRFSAAWVESKAKLVYDDVSDWLEGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKDRPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCAALALREHLGFGIYNVHTGFDPALVEQAASVLKANGVGADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTVPGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRMAERDVGDWLYARYLQPQAGTDTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDEVVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIARPVA
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNNC_TODPA
Sequence: MPVVISEKQFNDAHQAFKLHDKKDEGAVSNKELTNLFKSLALHVSDDKLQQWVDEMDEDATGVIRWEKFKILFERKVQEDEDERELRSAFRVLDKNNQGVIDVEDLRWILKSLGDDLNDDEIQDMINETDTDGSGTVDYEEFSALMLG
What is the function of this protein?
Troponin is the central regulatory protein of striated muscle contraction.  Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.  The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
What are the official names of this protein?
Troponin C, TN-C.
What is the protein family that this protein belongs to?
Belongs to the troponin C family.
Protein: YMC1_SCHPO
Sequence: MKPQTKLSENSSRCEKVLYSEVITQLIYFLTSKKITNLGKIRLVKSIRDSFLSQLENILCFFLVYRTTYSFGVCLMKRFLFNKFFNRHPFTRVKSCFSSSSPSKFSFTQWLVGFTDGDGCFSISKQKIKNGKNKWSLTFKLTQNLYNYRILYFIKRNLGIGSLYKESSTNTVIYRLRRREHLKKIIDIFDQFPLLTKKYWDYYLFKKAFLILEDANLNSFEKNSKLEEIRIEKKSLKQYSPVNLEKYLTKSWLIGFIEAEGSFYLLQKSPVRIIHGFEITQNYEQPLLAQISEFLFNSQISPKIKSKKNSLITNYSLSTSSKERMLFLSSYFENCFKGVKSLEFKIWSRSLRKNYNFEQLLRARDLIRKLKNKYSRGSQHPKDK
What are the official names of this protein?
Uncharacterized cox1 intron-1 45.6 kDa protein, Probable maturase.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FMT_LISMF
Sequence: MTKIIFMGTPEFSVPVLTQLASTYDVVAVVTQPDRPVGRKRVLTPPPVKKAALELAIPVYQPEKLRTSSELEELIALEADLLVTAAYGQILPNSLLESPKHGAINVHASLLPEYRGGAPVHYALLDGKTETGVTIMYMVEKLDAGDMISQRKIPITDEDNTGTMFDKLSKLGAELLMDTLPDFLAGKITAIPQDPEKVTFARNISREQEKIDWTKPGRTIFNQIRGLSPWPVAYTTLEEKPFKIWEATYEETKEDGEPGAILADKTTLKIVAGDGTLIVPTVIQPAGKPKMDVHSFMTGAGRNLSKTTRFGE
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: NQRD_VIBC1
Sequence: MSSAQNIKKSIMAPVLDNNPIALQVLGVCSALAVTTKLETAFVMTLAVTFVTALSNFSVSLIRNHIPNSVRIIVQMAIIASLVIVVDQVLKAYLYDISKQLSVFVGLIITNCIVMGRAEAFAMKSAPVPSLIDGIGNGLGYGFVLITVGFFRELFGSGKLFGMEVLPLVSNGGWYQPNGLMLLAPSAFFLIGFLIWVIRILKPEQVEAKE
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDE1C_MOUSE
Sequence: MESPTKEIEEFESNSLKHLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSDGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEQGTTSKGEKKTSGEAKSQVNGTRKGDNPRGKNSKGEKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKTDGTKKRSHGSPAPSTSSTSRITLPVIKPPLRHFKRPAYASSSYAPSVPKKTDDHPVRYKMLDQRIKMKKIQNISHHWNKK
What is the function of this protein?
Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8810348).  Exhibits high affinity for both cAMP and cGMP (By similarity).  Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials.  Regulates smooth muscle cell proliferation.  Regulates the stability of growth factor receptors, including PDGFRB (Probable).
What are the official names of this protein?
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, Cam-PDE 1C.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
What are the subcellular locations of this protein?
Lysosome.
Protein: TAL_MYXXD
Sequence: MKFFIDSADVEEIRKAHAMGCVDGVTTNPSLLAKVGRGLEETIREICSIVDGPISAECVSMEADELIKEGRSLAKIHDNVVVKIPMGVEGMKATKALTAEGIRTNVTLCFSANQALLCAKAGATYVSPFVGRLDDISQDGMELISHILEIYRNYEHFNTQVLVASVRNPVHVLQAARLGADVATLPYNVITQLANHPLTDAGIKKFLADWEKVPKAAKPPAAK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRKP1_AGACL
Sequence: MSFLKKSLFLVLFLGLVSFSICEEEKRETEEEENEDEMDKESEEKRESPERPPGFTPFRVD
What is the function of this protein?
[Hyp3,Thr6]-bradykinyl-Val,Asp: Induces relaxation of rat smooth muscle from tail artery (EC(50)=3. 5 nM) and contraction of that from ileum (EC(50)=223 nM), urinary bladder (EC(50)=1. 5 uM) and uterus (EC(50)=356 nM).  Binds to both bradykinin receptor B1 (BDKRB1) and B2 (BDKRB2); the effects via B2 a stronger.
What are the official names of this protein?
[Thr6]-bradykinyl-Val,Asp, Bradykinin-related peptide RD-11.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Bradykinin-related peptide subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ADE_RHIME
Sequence: MTAHLKKAELHCHIEGATPPELALRQARKYGVDTSAIIRDRAYVWEDFTSFVRCYDAVASLFRTEGDYALLAETYLTELAKAGTIYSEIIVSPDHGVTIGLGADAYIEGLAAGMEAARVKTGIESRMLITGIRHLGPDSVIRTAEYAAMRRHPLVTGFNLAGEERMHSVAEFSRAFDIVRDAGLGLTIHAGELSGAFSVRDALDHVRPARISHGVRAIEDGDLVKRLADEGVVLEVCPGSNVALQVFPDFASHPLRRLYEAGVRVTLNSDDPPFFHTSLAQEYEIAFHAMGFSDSEIDRMTKTAIEAAFVDEPTREKLLAALHV
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenine to hypoxanthine.  Plays an important role in the purine salvage pathway and in nitrogen catabolism.
What are the official names of this protein?
Adenine deaminase, ADE, Adenine aminohydrolase, AAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Protein: NBLIK_COREF
Sequence: MSENETSKTGGNAGVPGSGADAPSLSDSPAISGNDAVNLAAEQAKNTAHRNIPTLDDLPIPEDTANLRLGPNLHDGLLALLPLVGVWRGEGQADTPEGGQYSFGQQIIFSHDGENYLSFESRVWRLDSEGGTVGPDQRETGFWRINLQDEIEFVCAHASGVVEIYYGQPINERAWELESASTMVTATGPVTLGPGKRLYGLLPTNELGWVDERLVDKELKPRMSAQLHRIIG
What are the official names of this protein?
Ferric nitrobindin-like protein.
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: RS16_TREPR
Sequence: MLAIRLRRCGARGRPAYQVVVADSRRKRNGVFLCRVGYYNPRLKSAHIDTVMLRLWTERGAAPTRTVARLLHRHAAGCTAAARNSGSVCPHWQ
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: Y3150_TERTT
Sequence: MSYIIDRRLNSKKKSMVNRQRFLRRYQQHIKKAVSDAVDRRSITDIESGESISIPTRDISEPIFHHGSGGKNNRVLPGNDRFNGGDHIERPEQGQGGGGNGSGASDSGEGEDDFVFQISQEEFLNFLFEDLALPNLVKRQLAGNEEFEFRRAGISNEGSPGKINIIRSLRSANSRRIALTGKKRRRLKEVEAELEILEPESAEAQALLAEAEELHAKIKRIPWLDDFDLKYNLHVKHPLPTSKAVMFCLMDVSGSMDQATKDIAKRFFLLLYLFLQRNYERTEVVFIRHHTSAKEVDEQEFFYSRETGGTIVSSALKMMDDILQTRYPASEWNIYGAQASDGDNWNDDSVICYRLLTEKLLPKVQYYSYIEITTRERQALWHAYEQVLSDFPNTFAMRQLQSAADIYPVFRQLFQKQTT
What are the official names of this protein?
UPF0229 protein TERTU_3150.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: CLPP_CARRP
Sequence: MIFLPTVIDKNIKGDRFLDLYSKMLKERVIYLNGAIEDTMASLIVSQLMFLDSENSKDIILYINSPGGVVSSGLSIYDTIQFLKSDVSTICIGQAASMAAVLLAAGKKGKRFCFPNSRIMIHQPLGYAQGQASDVEIHAREMINIKQILCEILSSHTNNSIFQIFKDTDRDNFMNCKQTLKYGIIDNVLYKKWI
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_CAMC1
Sequence: MKDEKIAKKKLTINDIKNKKGAEPIVMITAYDALFAKIFDDYADVILVGDSLNMSFNMKESTLSADMSTMLYHTKAVCTGAKKSFILADMPFGSYTNEKQAIKNAMKFFKQTNADAVKLEVGMHQVNLVKRLCEEGINVMAHIGLKPQFFKFEGGYKIKGKSELEAKRLVEEALAFEQAGAFGILLEGTLSNVASEITRQVRVPVVGIGSGADVDGQVLVWSDMLGFFEDFKPKFVKRYLDGAALVRKGVQSYASEVKNKIFPSEEFSYKG
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_XYLFT
Sequence: MKFVDEAEIQVIAGNGGDGCVSFRREKFIPLGGPDGGDGGDGGSVWLVADENLNTLVDFRHERIFKAQRGVNGMGQQMYGKAGQDKIISVPIGTVVINVQTDEVIGDMVRHGDRLLVAKGGTGGLGNMHFKSSINRAPRQARPGEQGEERTLKLELKLLADIGMLGFPNVGKSTFIRAVSAATPKVADYPFTTLYPNLGVVKIEAYSSFVIADVPGLIEGAADGVGLGMQFLRHLQRTKLLLHMVDISATADAYGNEKVGVGLLPIEQVRKLEIELERHDPALLDKPRWLVLNKADLMPQEEAQALAEALIAELRWTAPWYLVSAVSREGTWPIMKSAMTLFEHQREVAAEQRVSSR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AB7C_ARATH
Sequence: MKQSYAMDNPIVFFLLESNYFPMFSIFFNLLLLLVMFGSCVYKKRLGWENSDAFTNERFKDMSLTYNKLVVICCETLSALNSVLLLLSCFNLHKNGWDRSELMILLDLLFTALSWGAISFYIRSQFTYSHDQKFPILLRVWWVLYFMFSCYRLLVDIALYKKQELVSVHLLLSDVLAVSVGLFLCYSCLQKQGQGERINLLLEEPLLNGAESSAATSVQLDKAEDDEVVTPFSNAGFLSHVSFSWMSPLIVLGNEKIIDSEDVPQVDNSDRAEKLFWIFRSKLEWDDGERRITTYKLIKALFFSVWRDILLSTLFAFVYTVSCYVAPYLMDTFVQYLNGQRQYSNQGVVLVTTFFVAKLVECQARRNWYFRLQKAGIGMRSVLVSMIYEKGLTLPCYSKQGHTSGEIINLMTVDAERISAFSWYMHDPWILVLQISLALLILYRSLGLGSIAAFAATFLVMLGNIPLAKLEEKFQGNLMESKDNRMKKTSEALLNMRILKLQGWEMKFLHKILDLRGIEAGWLKKFVYNSAAISSVLWAAPSFVSATAFGACMLLKIPLESGKIIAALATFRILQTPIYKLPDTISMIVQTKVSLDRIATFLCLDDLQQDGMERLPSGSSKMDVEVSNGAFSWDDSSPIPTLKDIRFKIPHGMNIAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRKAYIAQSPWIQSGKVEENILFGKPMQREWYQRVLEACSLNKDLEVFPFRDQTVIGERGINLSGGQKQRIQIARALYQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLRNKTVIYVTHQLEFLPEADLILVMKDGRITQAGKYNEILESGTDFMELVGAHTDALAAVDSYEKGSASAQSTTSKESKVSNDEEKQEEDLPSPKGQLVQEEEREKGKVGFTVYQKYMKLAYGGALVPIILVVQILFQVLNIGSNYWMAWVTPVSKDVKPLVSGSTLILVYVFLATASSFCILVRAMLSAMTGFKIATELFNQMHFRIFRASMSFFDATPIGRILNRASTDQSAVDLRLPSQFSNLAIAAVNILGIIGVMGQVAWQVLIVFIPVIAACTWYRQYYISAARELARLSGISRSPLVQHFSETLSGITTIRSFDQEPRFRTDIMRLNDCYSRLRFHAISAMEWLCFRLDLLSTVAFALSLVILVSVPEGVINPSFAGLAVTYALNLNSLQATLIWTLCDLENKMISVERMLQYIDIPSEPSLVIESTRPEKSWPCRGEITICNLQVRYGPHLPMVLRGLTCTFRGGLKTGIVGRTGCGKSTLIQTLFRIVEPAAGEIRIDGINILTIGLHDLRSRLSIIPQEPTMFEGTVRSNLDPLEEYADDQIWEALDKCQLGDEIRKKELKLDSPVSENGQNWSVGQRQLVCLGRVLLKRSKVLILDEATASVDTATDTLIQETLRQHFSGCTVITIAHRISSVIDSDMVLLLDQGLIEEHDSPARLLEDKSSSFSKLVAEYTASSDSRFKRSSMKTN
What is the function of this protein?
Pump for glutathione S-conjugates.
What are the official names of this protein?
ABC transporter C family member 7, ABC transporter ABCC.7, AtABCC7, ATP-energized glutathione S-conjugate pump 7, Glutathione S-conjugate-transporting ATPase 7, Multidrug resistance-associated protein 7.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PRR7_MOUSE
Sequence: MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPPPPHRSRLEAPVHAHSHVHVHPLLHHGPAPPHAHPHPHHHALPHPPPPHLAVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAAPCPALCLQAERSRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV
What is the function of this protein?
Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity).  Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (By similarity).  Might play a redundant role in the regulation of T cell receptor signaling (PubMed:27657535).  Might promote apoptosis in T cells (By similarity).
What are the official names of this protein?
Proline-rich protein 7, Synaptic proline-rich membrane protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein. Postsynaptic cell membrane; Single-pass type III membrane protein. Postsynaptic density membrane. Cytoplasm, perinuclear region. Synapse. Cell projection, dendrite. Nucleus. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity).
Protein: ILVC_ARCFU
Sequence: MAKIYRDADADLKYLDGKTVCIIGYGSQGHAHALNLKDSGVNVVVGLPEWDKATWERAEKDGMVVKKLSEAADGADVIAMLIPDMVQPAVYREHIQDKLKEGAMLMFAHGFNIHYNQIVPPEYVDVAMVAPKGPGPLVRRMYVEGKGVPSLVAVEQNYTGKALEVALAYAKGIGATRAGVIETTFKEETETDLFGEQVDLCGGVAEMIKMSFETLVEAGYQPEIAYFEVLHELKLIVDLIYEGGIYNMWSAVSETAKYGGMTRGKRIFTEQTREEMRKILKEIQTGEFAREWILENMAGRPVYNKLLQMEREHPIEKIGKELRAMMPWLKKD
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH or NADH to yield (R)-2,3-dihydroxy-isovalerate.  It is able to use both NADPH and NADH, but has a preference for NADH.
What are the official names of this protein?
Ketol-acid reductoisomerase (NAD(P)(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: YFH9_SCHPO
Sequence: MRPAKSVEGYIIIVTGVHPEATEEQVEDLFADFGPVKNLHLNLDRRTGYVKGYALIEYATLEQAQKAVDEKNLSLLDEKLEVDFAFLEPPERAPRPSISTRSRSQSPEVQHRDRDVAMAEP
What are the official names of this protein?
Uncharacterized RNA-binding protein C23A1.09.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DAD4_KLULA
Sequence: MENPYEKVQSNILARIIGNVERLNQSVVILNQELRRVNTKNKNLELMSQMCENYRESVDFQLQATSKKQDPL
What is the function of this protein?
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
What are the official names of this protein?
DASH complex subunit DAD4, Outer kinetochore protein DAD4.
What is the protein family that this protein belongs to?
Belongs to the DASH complex DAD4 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Protein: RL9_BORAP
Sequence: MKVILKEDFINLGREGDTVEVRDGFARNYLLPKGFAVFSNKHNVEIFNQKRRSILKKQETKKQIANDLKSKLDLVKLEFFMKSNDSGKLFHSINSLNIAEELFKLGFDIERKKIDIHHGTLKTFGTYDVTIKLYEGISSIIKVEIKKEEKQEDKKPLNKKLNKVDEQAERERV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: G3P_COLLN
Sequence: MAPIKVGINGFGRIGRIVFRNAVEHPDVEIVAVNDPFIETKYAAYMLKYDSTHGIFNGEIAQDGNDLVINGKKVKFYTERDPAVIPWKETGADYVVESTGVFTTIDKAKAHLQGGAKKVIISAPSADAPMYVMGVNEKSYDGSAVISQASCTTNCLAPLAKVINDKYTIIEGLMTTVHSYTATQKTVDGPSAKDWRGGRTAAQNIIPSSTGAPKAVGKVIPELNGKLTGMSMRVPTANVSVVDLTVRIEKGATYDEIKQAIKEAAEGPLKGVLAYTEDDFVSTDMIGNPNSSIFDAKAGISLNNNFVKLVSWYDNEWGYSRRVLDLLAHVAKVDASK
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.