PharMolix/UniProtQA huggingface dataset:
Protein: CEAS_STRCL
Sequence: MSRVSTAPSGKPTAAHALLSRLRDHGVGKVFGVVGREAASILFDEVEGIDFVLTRHEFTAGVAADVLARITGRPQACWATLGPGMTNLSTGIATSVLDRSPVIALAAQSESHDIFPNDTHQCLDSVAIVAPMSKYAVELQRPHEITDLVDSAVNAAMTEPVGPSFISLPVDLLGSSEGIDTTVPNPPANTPAKPVGVVADGWQKAADQAAALLAEAKHPVLVVGAAAIRSGAVPAIRALAERLNIPVITTYIAKGVLPVGHELNYGAVTGYMDGILNFPALQTMFAPVDLVLTVGYDYAEDLRPSMWQKGIEKKTVRISPTVNPIPRVYRPDVDVVTDVLAFVEHFETATASFGAKQRHDIEPLRARIAEFLADPETYEDGMRVHQVIDSMNTVMEEAAEPGEGTIVSDIGFFRHYGVLFARADQPFGFLTSAGCSSFGYGIPAAIGAQMARPDQPTFLIAGDGGFHSNSSDLETIARLNLPIVTVVVNNDTNGLIELYQNIGHHRSHDPAVKFGGVDFVALAEANGVDATRATNREELLAALRKGAELGRPFLIEVPVNYDFQPGGFGALSI
What is the function of this protein?
Involved in the biosynthesis of the beta-lactamase inhibitor, clavulanic acid.  Catalyzes the thiamine diphosphate (ThDP) dependent condensation of D-glyceraldehyde-3-phosphate (D-G3P) with L-arginine to yield the beta-amino acid, N2-(2-carboxyethyl)arginine (CEA) via a beta-elimination resulting in the formation of an enol which undergoes a second elimination to generate the alpha,beta-unsaturated acryloyl-ThDP.
What are the official names of this protein?
N(2)-(2-carboxyethyl)arginine synthase, CEA synthetase, CEAS.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: LEUD_PSE14
Sequence: MKAFTQHNGLVAPLDRANVDTDQIIPKQFLKSIKRTGFGPNLFDEWRYLDVGQPYQDNSKRPLNHDFVLNHERYQGASVLLARENFGCGSSREHAPWALEEYGFCAIIAPSYADIFFNNSFKNGLLPIILSEAEVDELFKQVEASPGYQLSIDLQAQTVTRPDGKVLSFEIDAFRKHCLLNGLDDIGLTLMDADAIASFESRHRASQPWLFRD
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: KAS2_STRVN
Sequence: MSTPDRRRAVVTGLSVAAPGGLGTERYWKSLLTGENGIAELSRFDASRYPSRLAGQIDDFEASEHLPSRLLPQTDVSTRYALAAADWALADAGVGPESGLDDYDLGVVTSTAQGGFDFTHREFHKLWSQGPAYVSVYESFAWFYAVNTGQISIRNTMRGPSAALVGEQAGGLDAIGHARRTVRRGPGWCSAVASTRRSTRGASSSQLSGGLVSTVADPERAYLPFDVDASGYVPGEGGAVLIVEDADSARARGAERIYVRSPLRRDPAPGSGRPPALGRAAELALAEAGLTPADISVVFADGAGVPELDRAEADTLARLFGPRGVPVTAPKALTGRLCAGGGPADLAAALLALRDQVIPATGRHRAVPDAYALDLVTGRPREAALSAALVLARGRHGFNSAVVVTLRGSDHRRPT
What are the official names of this protein?
Granaticin polyketide putative beta-ketoacyl synthase 2, ORF2.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Protein: GCSH_BACFN
Sequence: MNFPQNVKYTNEHEWIRLEGDVAYVGITDYAQEQLGDIVFVDIPTEGETLEAGEVFGTIEVVKTISDLFLPVAGEVVEQNPALEENPELVNKDPYGEGWLIKMKPANAADLDNLLDAEGYKAVVNA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: CAPP_SHIFL
Sequence: MNEQYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYERNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDLYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAKRRPTGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: ATPB_DECAR
Sequence: MSQGSIVQCIGAVVDIHFPRDAMPKVYDALKLDASEANGMAEDGLTFEVQQQLGDGVVRTIAMGSSDGLRRGMKVNNTGAGISVPVGMGTLGRIMDVLGRPIDEAGPIDSTELRVIHQPAPKFDELSSSVDLLETGIKVIDLICPFAKGGKVGLFGGAGVGKTVNMMELINNIAKQHAGLSVFAGVGERTREGNDFYHEMKDSNVLDKVAMVFGQMNEPPGNRLRVALTGLTMAERFRDDGRDILFFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGRLQERITSTKVGSITSIQAVYVPADDLTDPSPATTFLHLDSTVVLSRDIASLGIYPAVDPLDSTSRQLDPQVVGEEHYSVARAVQMNLQRYKELRDIIAILGMDELSPEDKLAVSRARKIQRFLSQPFHVAEVFTGSPGKFVSLKETIKGFKGICAGEYDHLPEQAFYMVGGIEEVIEKAKTL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATPG_XANCB
Sequence: MAGGREIKTKIKSVQNTRKVTRALEMVSASKIRKAQERMKTSRPYAQAMKQVIGHLAQASTDYQHPFLVEREQVKRVGYIVISSDRGLAGGLNNNLFRKMLGEVRPWQDKGAEIDVVTIGQKASAFFRRIKVNMVGSVTHLGDSPHIEQLVGVIKVMLDAFTEGKVDRVYLVYNRFVNTMTQKASFEQLLPLPAAEHKVAHHDWDYLYEPDAATVLEHVMTRYIESLVYQAVLENVASEHAARMVAMKAASDNANKMIGTLQLVYNKARQAAITQEISEIVSGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FLHD_ECOHS
Sequence: MHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITQLTQDSRVDDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPX_STRP2
Sequence: MVTFLGNPVSFTGKQLQVGDKALDFSLTTTDLSKKSLADFDGKKKVLSVVPSIDTGICSTQTRRFNEELAGLDNTVVLTVSMDLPFAQKRWCGAEGLDNAIMLSDYFDHSFGRDYALLINEWHLLARAVFVLDTDNTIRYVEYVDNINSEPNFEAAIAAAKAL
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: MCM4_DROME
Sequence: MSSPARSPSVGGATPKQGARTPTRGIASQDVETPMRMGPGRAVRPSDNISLPPTSPGNISLPATSPARGLGANMSEIDLSSPLNYGTPSSMGSIRTPRSGIRGTPLRARPDIRTDKRIRQVAIGGGSGLEPIPEKGSETTDPVSESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFERYPAALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHVDVVHFRKVDNKRLYEDEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEEDTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKEGSQIMITREQFEDALKEVQDEGAIVVMGKNTIRIC
What is the function of this protein?
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.  Required for DNA replication and cell proliferation.  Essential role in mitotic DNA replication but not in endoreplication.
What are the official names of this protein?
DNA replication licensing factor MCM4, Protein disc proliferation abnormal.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus.
Protein: C14F5_SCHPO
Sequence: MKRSYKDIIRFLKLIGISHSTAIKLVDGILPVMIGLKTSYLVDCVFLEISELREIIEFVGPDCLRGIYFTEPISQCFVLHVANWEEWSSIDSLVPIVVDLPSKKQNRLLQSCITKHVDRLLDLCKRNLSTFTIDISSSWRQNIIENNEQKEFECTSTAITGCLLNYGATYNYDHTLFKDNGLSCETLKLYTLEVHSKKKDVSDTLIQFSCVNQFEEPVTSNIQRLTSLYQTRWKRINSEEKRNWEEWIKHKYKIPNDTNIELEFCFSVTDRKEQSVIL
What are the official names of this protein?
Uncharacterized protein C14F5.01.
Protein: RAD14_CANAL
Sequence: MASHIRGNLTEEQLKRIEANRKRALERLQQKKKKDAGEHVPSSTPKSTSTTTTKETGSYSPTKTLSQIVNSDSVQVSSKFVEIETDGSVKKRRVLTEEQRQKIEQNRLRAIEIQKNLKQRENQKDDSTTSSKPVDNIRLNQNRPDSVVSSTKKFQPPPIRKQDYIEFDFATMKDTKGGFLQDEKTNTQGADEQTLQDWKNKQRELQKIRELPPPIDLQNIPRCRECQSMEVDANLMTNFNVRACRKCIKALPEKYSLLTKTECKEDYLLTEPELQDTTLLPRIEKPNPHGYSRMQLFVRFQVEEFAWKKWGGPEELDKEWERREENKVKRKEKKYHDQLREMRKRTRAEEYTRKLRDGKSLGERHVHDWSSPVNIDKHTIKRRCIDCGIETEEVVI
What is the function of this protein?
Involved in DNA excision repair.
What are the official names of this protein?
DNA repair protein RAD14.
What is the protein family that this protein belongs to?
Belongs to the XPA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DOF11_ARATH
Sequence: MPTNSNHQHHLQHQLNENGSIISGHGLVLSHQLPPLQANPNPNHHHVATSAGLPSRMGGSMAERARQANIPPLAGPLKCPRCDSSNTKFCYYNNYNLTQPRHFCKGCRRYWTQGGALRNVPVGGGCRRNNKKGKNGNLKSSSSSSKQSSSVNAQSPSSGQLRTNHQFPFSPTLYNLTQLGGIGLNLAATNGNNQAHQIGSSLMMSDLGFLHGRNTSTPMTGNIHENNNNNNNENNLMASVGSLSPFALFDPTTGLYAFQNDGNIGNNVGISGSSTSMVDSRVYQTPPVKMEEQPNLANLSRPVSGLTSPGNQTNQYFWPGSDFSGPSNDLL
What is the function of this protein?
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.  Enhances the DNA binding of OBF transcription factors to OCS elements (By similarity).  Involved in the regulation of root development (PubMed:23057675).  The PEAR proteins (e. g.  DOF2. 4, DOF5. 1, DOF3. 2, DOF1. 1, DOF5. 6 and DOF5. 3) activate gene expression that promotes radial growth of protophloem sieve elements (PubMed:30626969).  Element of a regulatory network controlling indole glucosinolates (IGS) biosynthesis, probably by inducing the expression of accurate genes (e. g.  CYP83B1).  Promotes apical dominance (PubMed:16740150).
What are the official names of this protein?
Dof zinc finger protein DOF1.1, AtDOF1.1, OBF-binding protein 2, Protein PHLOEM EARLY DOF OBP2, Protein UAS-TAGGED ROOT PATTERNING 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: CITG2_SALTY
Sequence: MMPIPANPTNASIQPQSLYDVWADLAWRAMLTEVNLSPKPGLVDRLNCGAHKDMALADFHRSAEAIRHWLPRFMEYGASCTRLPPESVLAGLRPLGMACEAAMFRATAGVNTHKGSIFSLGLLCAAIGRLYQLRQPIAAETLCATAADFCRGLTTRELRQNNLQLTAGQRLYQQLGLTGARGEAEAGYPLVIRHALPHYRALLAQGRDPELALLDTLLLLMSLNGDTNVASRGGADGLRWLQQQAAVLLQQGGIRTPDDLVYLHRFDQQCIERNLSPGGSADLLIVTWFLAQISQVNH
What are the official names of this protein?
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase 2, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase 2.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: PURBB_XENLA
Sequence: MADGDSGSERGGSSGGPSGFSQHMSREQETQELASKRLDIQNKRFYLDVKQNAKGRFIKIAEVGAGGSKSRLTLSMAVAAEFRDYLGDFIEHYAQLGPSSPEQIAQASGEDGAGGPGGPRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQTINRGPGFSGGTGGGPGLQSGQTIALPAQGLIEFRDALAKLIDDYGGEDDEGMGLGSGASGGGAGGGGMYGELPEGTSITVDSKRFFFDVGSNKYGVFLRVSEVKPSYRNSITVPLKAWGKFGGAFCRYSEEMKEIQERQRDKMYDRRGPGERGGSLGPGAGGGGDDSETEDVDDD
What is the function of this protein?
May bind repeated elements in single-stranded DNA and may participate in transcriptional and translational gene regulation.
What are the official names of this protein?
Transcriptional activator protein Pur-beta-B, Purine-rich element-binding protein B-B.
What is the protein family that this protein belongs to?
Belongs to the PUR DNA-binding protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS6_ECOUT
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYTAAITGAEGKIHRLEDWGRRQLAYPINKLHKAHYVLMNVEAPQEVIDELETTFRFNDAVIRSMVMRTKHAVTEASPMVKAKDERRERRDDFANETADDAEAGDSEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: CEF1_EMENI
Sequence: MPVVKGGVWTNIEDEVLRAAVSKYGLNQWARVSSLLARKTPKQCKARWVEWLDPGIRKVEWSREEDEKLLHLAKLMPTQWRTIAPIVGRTATQCLERYQKLLDEAEARENDELGLGGPGTEASAPSADDVRRLRPGELDPDPESKPARPDTIDLDEDEKEMLSEARARLANTQGKKAKRKARERQLEESRRLAVLQKRRELKNAGINIKIVTRKPGEMDYNADIPFEKPAAPGFYDTTEEEARNERQREMFDPRKQQLANKRKGDQDEEAERKKRKNDKNSNSAAFAAAARAGQMQKIREAEQSSKRRALVLPTPQVSESEMEDIIKMGMAGDKASKMVGDEEGTKGLLGNYSAMVGGTPIRTPRAPPEEDHIANEIRNIRALTETQSSLLGGENTPLHDGGSSTGFDGIAPRRQQIVTPNPMATPFRQGNAVSATPVPGGAGPGATPLRTPRDHFSLNKEISGGLPIGSTPREIKMRENLARQSIRGRLAALPKPKETEWELEQLPSESAEPAGATEYPEEDSAVRDAREKEIRKRAAEAEHKRQTQVYQRSLPRPVVLDIDALMERASRVMDPITGLIAKEAALLVANDACKFATPGAKIEGKPRKLERLDDKYLEEARAAIASEASSGKLEEWSNEFDAKWSSSRQDTLPGLSNYLDDDEEDAYQQEQRIIGVFDNVQASLLATAEDGNKLEKKLALHYGGYQNRAKMLRAKITEAHTALEKSKHELDAFRTLQISEEAAISRRLEKLREEVAFVMRREREAQEQYRCRKDELDDLVASTGGMVNGWH
What is the function of this protein?
Involved in pre-mRNA splicing and cell cycle control.
What are the official names of this protein?
Pre-mRNA-splicing factor cef1.
What is the protein family that this protein belongs to?
Belongs to the CEF1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PYRB_CITBB
Sequence: MGFRHKDIIALKDLTKEEITLLLDTADSLSEINQRDIKKVPTLRGKTVINLFYEASTRTRTSFEIAAKRLSADAVNITASTSSVVKGETLSDTANNLLAMKPDIIVMRHAVSGAHEYLAKRVSCSVINAGDGAHEHPSQGLLDMLTMRQKFGKLDGLKVAIIGDITHSRVARSDIYGLTTMGSHVFLAGPPTMMPVGIERLGNVTVCKDMREAVDKADVVMMLRIQLERQGKTLLPSMREYSRYFGLNPEVLGLAKKNAIVMHPGPINRGVELASSVADCDQSAILTQVENGVAVRMAMLYHVCGGEPVE
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: DPMPI_MACPH
Sequence: MVAETGTGLFSAHKITEELASTSLDSGVHLLFDIHDRTFQALPDFLAEHRYQEVNDIRNTVFQKAFDTNLSIYEYLVHHPQLQAHMQDAMKLHQPEGDWLSVFPADEIVGNQQTAPDPARVLFVDIGGGMGQQCIRFRERYPDLAGRVILQDIPQTINRVPKPMPNGIEAVPHSFEDPQPIKSKSPRLDNLARERL
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpmpA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpmpD through the action of the prenyltransferase dpmpC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpmpE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpmpB (Probable).  The short chain dehydrogenase/reductase dpmpG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpmpH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Higginsianin B is further methylated by the methyltransferase dpmpI to produce the intermediate named FDDP B (PubMed:32286350).  The cytochrome P450 monooxygenase dpmpJ then oxidizes the C-26 methyl to primary alcohol, producing the final diterpenoid pyrone with a C-26 primary alcohol on the gamma-pyrone moiety named FDDP C (PubMed:32286350).
What are the official names of this protein?
O-methyltransferase dpmpI, Diterpenoid pyrone biosynthesis cluster protein I.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: FPG_RHIE6
Sequence: MPELPEVETVKRGLAPAMEGARVARLELRRQDLRFPFPEALADRVSGRTIVGLGRRAKYLLVDLDDGNTLVSHLGMSGSFRIEEGAASAMPGEFHHARTKDEKHDHVVFHLEGQGGPRRVVYNDPRRFGFMDMVRRADLAAHPFFRDLGPEPTGNDLGAAYLAERFRDKAQPLKSALLDQKNIAGLGNIYVCEALWRSHLSPIRAAGTLVTPGGKPKEKLGLLVASIRDVIADAIAAGGSSLRDHIQTDGSLGYFQHSFSVYDREGQACGTPGCGGTVARIVQAGRSTFYCAACQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: S6OS1_MOUSE
Sequence: MNDNLFVSLDRLLLEFVFQYEQDISIKEDTIQRINKCLESIKENKANVSKLREAINKVDEDIAFHYKHSKEIKDSCSNWKPTCDVFHKHEDYIKDQLTAYQETNEKDKKMYHDYICQYEDVLKQYQLKYSETRFSCKYYEKKKEHEEIKNRVLACTEQLQLNETILMKFLVPAPFPSLTKWTLYVVNLRYRTQDILKRANNFTKRSFELEKEADDMEIEINSLNKMARLFESKTFSEALDEKNKNTEKRKEFEERIFEKDEQVSNRSSQNSQLLLPCESQKFVRNMNSSEARVTDKKEESSANQSKFVRSDVRQKENNPQIFNDSGMDSNSKSSHIPAVKSSQGFMQFRLNQPNYNQRIEKEHIDAECGDKETVRQVRESKCSTQALYIEHFGKSIENNSVEEERDENFPQTPETPSFLRTPEALKTPESMEKMQFPKSPFFEITKNATSEGHKQKDSPGFSFLMSYTSRSPGLNLFDSSVSDSEISSDQFNEHYSAVNLNPSSSQQGIGNLFGKSEGEDAFTFSFSSDSSHTFGAGKDDFSFPFSFEQDPSTMTSSSSKDFSSSQNKTQFMFF
What is the function of this protein?
Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination (PubMed:27796301, PubMed:33508233).  Required for the appropriate processing of intermediate recombination nodules before crossover formation (PubMed:27796301).
What are the official names of this protein?
Protein SIX6OS1, Six6 opposite strand transcript 1 homolog.
What are the subcellular locations of this protein?
Chromosome. Note=Component of the central element of the synaptonemal complex (PubMed:27796301). In spermatocytes, detected from zygonema to pachynema and localizes along synapsed lateral elements (PubMed:27796301). Loading to the central element of the synaptonemal complex is dependent on the assembly of the tripartite synaptonemal complex structure that occurs upon synapsis between homologous chromosomes (PubMed:27796301).
Protein: Y776_MYCBP
Sequence: MTYTGSIRCEGDTWDLASSVGATATMVAAARAMATRAANPLINDQFAEPLVRAVGVDVLTRLASGELTASDIDDPERPNASMVRMAEHHAVRTKFFDEFFMDATRAGIRQVVILASGLDSRAYRLAWPAQTVVYEIDQPQVMEFKTRTLAELGATPTADRRVVTADLRADWPTALGAAGFDPTQPTAWSAEGLLRYLPPEAQDRLLDNVTALSVPDSRFATESIRNFKPHHEERMRERMTILANRWRAYGFDLDMNELVYFGDRNEPASYLSDNGWLLTEIKSQDLLTANGFQPFEDEEVPLPDFFYVSARLQRKHRQYPAHRKPAPSWRHTACPVNELSKSAAYTMTRSDAHQASTTAPPPPGLTG
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase BCG_0776c.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: CFM3_ORYSJ
Sequence: MAAAAMAISPSIHLHLHLHLHHPPRLHRLLHLSTTSPYPWLSAWPTAHRRRVPLRRPASALDLRPEPSPSSDSDDDAAFGTSRSSSRSAMSLILSRLRNSGYSYSPPELPPRPPRGSVEDVFRVDDGVVPNARGGFDDDAESALVDARFPWELPMPPPEAGPRAARSKAWMAELTLPEAELRRLRHAGMRLKSRIKVGGAGVTREIVERIRDRWRNDEVVRIKVTGTPALNMRLFHEILERKTGGLVIWRSGTSVSLYRGVAYDIPEPTKGTSKNTQTLGMKSSIKEPPGHSLLPNEKVNEMQDNNGALVSNAEKDTLVEPVPEIKYEDEIDKLLDELGPRYDDWPRPDPSPVDADLLPATVPGYKPPFRVLPYGVRPSLSRRDTTNLRRLARGLPPHFALGRSRQLQGLAAAMVKLWEKSSIAKIALKRGVQLTTSERMAEDIKKLTGGVMLSRNNDFMVFYRGKDFLSPELAEKLLERERWAKSLQDEEQARLNAASSFSSRTEAPVEPTVAGTLGETLEANSKYGNKLDENYENKMTRTVEAARHADLVRKLEWKLQLAQKKIEKAERVLGKVETALKPTEGIQPPETITDEERFMFRKLGLRMKAFLLLGRRGVFDGTIENMHLHWKYRELVKILVKAKSFGDVKKIALSLEAESGGILVSVDKVSKGYAIVVFRGKDYARPSKLRPRNLLSKRKALARSIEIQRREALSHHIATLNRRVKKLKAELLQMEGVKEEGDVELYAKLDSAYSSDEEDVEDEDDEAYLRSFDNSVAVQNGDDRTSLDGSDANSDDEGDYSDEDDDEDDDNDEEDGFDYENDDEDDVPPTTSDGDLYNHTDFGSSDSENYVSLSGRGDPDVKSKGSALDSRNSYSEQSTELTNTCS
What is the function of this protein?
Binds specific group II introns in chloroplasts and facilitates their splicing.  Acts on subgroup IIB introns.  The substrates of the subgroup IIB also require the CRM domain proteins CAF1 or CAF2, with a simultaneous binding of CFM3 and CAF1 or CAF2 (PubMed:18799595).  May influence the biogenesis of the mitochondrial small ribosomal subunit (By similarity).
What are the official names of this protein?
CRM-domain containing factor CFM3, chloroplastic/mitochondrial, Protein CRM FAMILY MEMBER 3, OsCFM3.
What are the subcellular locations of this protein?
Plastid, chloroplast. Mitochondrion.
Protein: GLN1A_STAAS
Sequence: MPKRTFTKDDIRKFAEEENVRYLRLQFTDILGTIKNVEVPVSQLEKVLDNEMMFDGSSIEGFVRIEESDMYLHPDLDTWVIFPWTAGQGKVARLICDVYKTDGTPFEGDPRANLKRVLKEMEDLGFTDFNLGPEPEFFLFKLDEKGEPTLELNDDGGYFDLAPTDLGENCRRDIVLELEDMGFDIEASHHEVAPGQHEIDFKYADAVTACDNIQTFKLVVKTIARKHNLHATFMPKPLFGVNGSGMHFNVSLFKGKENAFFDPNTEMGLTETAYQFTAGVLKNARGFTAVCNPLVNSYKRLVPGYEAPCYIAWSGKNRSPLIRVPSSRGLSTRIEVRSVDPAANPYMALAAILEAGLDGIKNKLKVPEPVNQNIYEMNREEREAVGIQDLPSTLYTALKAMRENEVIKKALGNHIYNQFINSKSIEWDYYRTQVSEWERDQYMKQY
What is the function of this protein?
Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism.  It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.  Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA.  During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation.  Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity.  In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I alpha, GSI alpha.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.