PharMolix/UniProtQA huggingface dataset:
Protein: ADT1_RABIT
Sequence: MSDQALSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGAAQREFSGLGNCLTKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQTVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWKKIAKDEGAKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV
What is the function of this protein?
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).  Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).  In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity.  Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis.  Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity).  Proton transporter activity requires free fatty acids as cofactor, but does not transport it.  Probably mediates mitochondrial uncoupling in tissues that do not express UCP1.  Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1. 5 kDa, and which contributes to cell death.  It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity).  Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity).
What are the official names of this protein?
ADP/ATP translocase 1, 30 kDa calsequestrin-binding protein, 30 kDa CSQ-binding protein, ADP,ATP carrier protein 1, Adenine nucleotide translocator 1, ANT 1, Solute carrier family 25 member 4.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A4/ANT1 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (By similarity).
Protein: C719A_PIPNI
Sequence: MESGSSIDLSPLDLVAAILQGKADASSLLSLTRSTVSDGNGDLLVLLATSAALLVGLVAALVWRRSAAARTAEPPKPLLAKKEAEPEVDDGKRKVTVFFGTQTGTAEGFAKAFAEEAKARYEKAAFRILDLDDYAADDDEYEEKMKEETLAFFFLATYGDGEPTDNAARFYKWFAEGKDTGNFFEKMQYGVFGLGNRQYEHFNKIAKVVDELLAEQGAKRLVPLGLGDDDQCIEDDFTAWRELIWPELDQLLRNEDDVSGASATYTAAIPEYRVVFYDHEDSRIQEKKNANGYANGHASYDIQHPCLANVAVRRELHTPASDRSCTHLEFDVSGLGLHYETGDHVGVYAENCIETVEKAECLLGLSPATIFSLHTDQVDGTPLSGSFLPPPFPSPCSLRTALAKYADLLSSPKKAALVALASYASEPSEAKRLQFLASPSGKDEYSQWIVANQRSLLEVMAEFPSAKPPLGVFFGAIAPRLQPRYYSISSSPKVAPTRIHVTCALVYEPTPTGRIHKGVCSTWMKNAVPQEESSNCSSAPISVRQSNFKLPMDTSLPVIMIGPGTGLAPFRGFLQERLALKDAGFNLGPAVLFFGCRNRKMDFIYENELNEFVEAGVLSDLIVAFSREGPTKEYVQHKMAEKAVDIWNMISQGGYVYVCGDAKGMARDVHRALHTIVQEQGSMDSSKVESYVKNLQMEGRYLRDVW
What is the function of this protein?
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes.  It can also provide electron transfer to heme oxygenase and cytochrome B5.
What are the official names of this protein?
Piperic acid synthase CYP719A37, Cytochrome P450 719A37, PnCYP719, NADPH--cytochrome P450 reductase, CPR, P450R.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: PYRG_PHOPR
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMMKLDPYINVDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFIRTKMTKRNNFTAGRVYEEVLRKERRGDYLGATIQVIPHITNEIKERVIAGSEGHDIAIVEVGGTVGDIESLPFMEAIRQLAVQKGRERTMFMHLTLVPYLAAAGEVKTKPTQHSVKELRSIGIQPDILICRSDRVIPANERAKIALFCNVQEKAVISMKDVDSIYKIPQLIKAQGLDDFVCKRFGITAPEANLAEWEQVIYEEANPTDEVTIGMVGKYIELPDAYKSVNEALKHAGLKNRLSVKIKYIDSQDVEAKGFEMLEGLDAILVPGGFGSRGIEGKIRTAQYARENKIPYLGICLGMQVALIEFARNVAGLADAHSTEFNAETKNPVVGLITEWVDSEGKVEERTENSNLGGTMRLGSQLCHLKNGSKARELYGNASIHERHRHRYEVNNNLLPQLEKAGLKISGLSADKKLVEIIEMPNHPWFVAAQFHPEFTSTPRDGHPLFEGFVKAAGQQLRGELK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: RL11_MESFL
Sequence: MAKRITRIAKLEFMAMQAKPGAELASLGINMPEFTKQFNDATKDRAGDVVPVVITAYDDKSFDFILKTTPAAILLKKAAGIEKGASNAKTQTVATISADKVREIAEYKLVDLNANDVEAAMKIIAGTAKNMGIKITGMEETN
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: Y009_OSHVF
Sequence: MACSKMSVDLECCICLEEDIERVDTIPCQHTVCRPCYLKPMINKCPVCRVRWIARERDPLAKDYTGEHYAHTYGFFAVNIDEESEEEEEEQVIEEEPQTPEIDPEEIELPRRFVDERIEYFLATGLRIDYVLTRGYCPSIQADEQEVLYLPLYTIYCNAYDANDDILHGQEIEITIQITRGECGSGWCEAQFVYVSITDSEDSGPKPITHSVKGGIGAVRFSREEIEFELQTPLPIESRTSYSHFEWEITTPYFKINQTGEELYPWAVLDFYEEEFWEPIVEPLDGPVDVDMSSYSAIGGIASMLRVTAAARRDNDEQYNEIIGRHVSRKVLNGGAEKDYIYLREINGKEFSIYDKIGNCFVGTNKTGITLPFTHVPSPAAIRGNHHILKEPEYIYGEERDTSYETALQSFDDWELIKREELLQRRYKREEQNLKYTSNRLFYFEKEFEEIMEDKWAIESYMCEDDDNTKPEYTTDMRVACEQRDRHGTDIVKCRLDKEVGSRRMHTLIDGESGVGKSFLAGHLSRGLVFDLDWITPNEDGSKPELPEDLHYPIIILGKRFDYDMREITKRLLYKKEYVVVKLSYMYFFYCI
What are the official names of this protein?
Putative RING finger protein ORF9.
Protein: HIS4_CARHZ
Sequence: MILIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGESENFEVIAEIIKNVSIPVQVGGGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEMLTLDRDKVAVGIDAKNGWVAIKGWVESSNYRALDLAYKVKEMGVTTIIYTDIARDGSLTGPNFNETLKLAIDTGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGKIDLKEGIRILEGES
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPN_ECOLI
Sequence: MTQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA
What is the function of this protein?
Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
What are the official names of this protein?
Aminopeptidase N, Alpha-aminoacylpeptide hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: EPAG_HUMAN
Sequence: MNLYLHPKLWPQLAGTKTLHVADAQRVRKITVHDGIWDAELPRAKRNHSYHLRYHGSSYSRCFLERYRCKTIGVFRRSNQPDCLETRSEKAKNRDGVVQEKSVRTLFSECVNQCDIRRRPTRFLRMFYHQKHFQLGLKGTETEKNERRL
What is the function of this protein?
May function as an early signal that helps mediate the activation of T-cells.
What are the official names of this protein?
Early lymphoid activation gene protein, DIAPH2 antisense RNA 1, DIAPH2 antisense gene protein 1.
Protein: ATPG_LEPIC
Sequence: MATPREIKKRINSVKNTRKITRTMEMVSTAKSKKISDRVNASHPFSNKIKELVSSLASLGGVVHSPYLRRPEKIKTVALLIITANRGLCGGYNSNVNRMAKAKIQEWKKSGVNVRLFIVGKKGISFFKFAGEKAEKTYTHLDDKSGYREAEEFANLFLELFAKEEVDVVEIASTVYYSSASQKPEVTRVLPLEPAGEGSVSDMMVYEPSPEKVLESLLPLVVKTAFLKAILEANCSEQIARRIAMKSATDAASEMIKLLTRGYNRVRQAKITQEISEIVAGADSLN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NUOK_SULSY
Sequence: MVPFEYYVALSGLLMVLGFIGVIIRKNIIAMLLSTELMLNAVNIAFVAFDMKLHDVVGQVFVFFILTIAAAEAAIGLGLIIAIYRMKKDVDVEKLTELKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PROF2_SOYBN
Sequence: MSWQAYVDDHLLCGIEGNHLTHAAIIGQDGSVWLQSTDFPQFKPEEITAIMNDFNEPGSLAPTGLYLGGTKYMVIQGEPGAVIRGKKGPGGVTVKKTGAALIIGIYDEPMTPGQCNMVVERLGDYLIDQGY
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin-2, GmPRO2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: NAGB_VIBCH
Sequence: MRLIPLKAAAQVGKWAAAHIVKRINEFQPTAERPFVLGLPTGGTPLATYKALIEMHKAGEVSFKHVVTFNMDEYVGLAADHPESYRSFMYNNFFNHIDIQEENINLLNGNTDDHEAECKRYEDKIKSYGKINLFMGGVGNDGHIAFNEPASSLSSRTRIKTLTEDTRIANSRFFDGDINQVPKYALTIGVGTLLDAQEIMILVTGHNKALALQAAVEGSVNHLWTVSALQLHPKAVIVCDEPSTQELKVKTVKYFTELEAKNIVGF
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: SMO_CHICK
Sequence: GPCWLWALALGLALGPRRCPAAPLNASAAPPERCRRPAACERLRFGSCLGSALPYAHTSTLLAADSGSQEEAHGKLLLWSGLRNAPRCWDVIQPLLCAVYMPKCEDGQVELPSQTLCQATRAPCTIVERERGWPDFLKCTPDRFPEGCPNEVQNIKFNSSGQCEAPLVRTYNPKSWYEDVEGCGIQCQNPLFTETEHREMHVYIAFSSVTISCTFFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGCVAQFMDGARDEIVCRADGTMRLGEPTSNETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTYQPLLGKTSYFHLITWSIPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVFITFGCHFYDFFNQAEWERSFREYVLCEANVTIATQTNKPIPECEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATLLIWKRTWCRLTGQSDDQPKRIKKSKMIAKAFSKRKELLRDPGRELSFSMHTVSHDGPVAGLAFDINEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEERSNLWVVEADVSPELQKRSRKKKRRKKKKEEVCPERRAGLSVAPLTPSSVPRLPRLPQQPCLVAIPRHRGDTFIPTVLPGLSNGAGGLWDGRRRAHVPHFITNPFCPESGSPEDEENPGPSVGHRQHNGGRRWPPEPLPGGSGVTRTRGRRAGLAPIHSRTNLVNAELLDADLDF
What is the function of this protein?
G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling.  Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched.  When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes.
What are the official names of this protein?
Protein smoothened.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HEM1_HUMAN
Sequence: MESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPERVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLELKPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKLVSAQA
What is the function of this protein?
Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.
What are the official names of this protein?
5-aminolevulinate synthase, non-specific, mitochondrial, ALAS-H, 5-aminolevulinic acid synthase 1, Delta-ALA synthase 1, Delta-aminolevulinate synthase 1.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane.
Protein: MCH_CERS4
Sequence: MKTNAGRFFEDYRLGETIAHAVPRTVSGGERALYHALYPARHALSSSDEFARACGLPAAPVDELMAFHLVFGKTVPDISLNAVANLGYAEGRWLKPVFPGDTLRAESTVIGLKENSNGASGVVWVRTRGLNQQGEAVLSYVRWVMVRKRDTAAPAPAPTVPELAGSVAASDLVIPEGLSFTDYDLTLAGEPHRWGDYAVGEKIDHVDGVTVEESEHMLATRLWQNTAKVHFDATNRPDGRRLIYGGHVISLARTLSFNGLANAQMIVALNAGAHANPCFAGDTVRAWSEVLDKAETADPGVGALRLRLVAMKHGTEPFVTRSEDGKYLPGVLLDLDYWALVPR
What is the function of this protein?
Involved in the ethylmalonyl-CoA pathway for acetate assimilation.  Catalyzes the reversible hydration of mesaconyl-CoA (2-methylfumaryl-CoA) to yield beta-methylmalyl-CoA ((2R,3S)-beta-methylmalyl-CoA).
What are the official names of this protein?
Mesaconyl-CoA hydratase, 2-methylfumaryl-CoA hydratase, Beta-methylmalyl-CoA dehydratase.
Protein: Y1445_THESM
Sequence: MRKGFVKEVLSKIKYDARENEEDYYIVIEHRGTYGNIKKIPVKMITLGHGYFFIEDTQIPYHRILAVIKKDGKVVWKKRGLGDEFKF
What are the official names of this protein?
UPF0248 protein TSIB_1445.
What is the protein family that this protein belongs to?
Belongs to the UPF0248 family.
Protein: ATPD_CLOBA
Sequence: MYEYLDRRYALALYQVAEKKGKVDEYLQDLREICELIENNHEFYEVIKHPQISTKKKKKTFISIFKDKIDEELLSFLLILIEKDRILYLREKLNEMEKIDLERKNTLKGIIKTAIPLLSNEFDNLRDIFQKKYDKNILFETEVDRNLLGGVYVRVGHDVIDDTVKSKIEEMKDLMLKQK
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TSAD_LACCB
Sequence: MAARELILAFESSCDETSVAVVENGDTILSNIIATQIKSHQRFGGVVPEVASRHHVEQITLVTDAALKEAGVTYDDLTAVAVTYGPGLVGALLIGVTAAKTIAYAHHLPLIPVNHMAGHIYAARFVKPLAYPLLALAVSGGHTELVYMRSAGEFEIIGDTRDDAAGEAYDKVGRILGIPYPAGKEVDRLAHLGQDTFHFPRAMDKEDNLDFSFSGLKSAVINTVHHAHQLGQELSREDLAASFQAAVVDVLVHKTQKALHQYPVKQLIVAGGVAANQGLKEAMNETLAVNFPDVDVIVPPLRLTGDNGAMIGAAAHIEWAKQHLASESLNADPGLSFTHAS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASZ1_CHLAE
Sequence: MAAGALRGLPVAGGGESSESEDDGWEIGYLDRTSQKLKGLLPIEEKKEKFKKAMTIGDVSLVQELLDSGISVDSTFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQTILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEDTICKILTTDSDREKDHIFSSYTAFGDLEVFLHGIGLEHMTDLLKERDITLRHLLTMREDEFTKNGITSKDQQKILAALKELQVEEIQFGELSEEIKLEISGDEFLNFLLKLNKQCGHLITAVQNIITELPVNSQKITLEWASPRNFTSVCEELVNNVEDLSEEVCKLKDLIQKLQNERENDPTHIQLREEVSTWNSRILKRTAITVCGFGFLLFICKLTFQRK
What is the function of this protein?
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.  Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process.  Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons.  May act by mediating protein-protein interactions during germ cell maturation (By similarity).
What are the official names of this protein?
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1, Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By similarity).
Protein: LUXS_ALIB4
Sequence: MPLLDSFRVDHTIMPAPAVRVAKVMQTPKGDDITVFDLRFCVPNKSMMSEKGTHTLEHLFAGFIRNHLNSPTVEIIDVSPMGCRTGFYMSLIGTPSEQEVAVAWKKAMEDVLKVENQSDIPELNLYQCGTCAMHSLDEAKDIARDILKSQIGVMSNKELYLSEEKLKSLGN
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: PDAD_METTH
Sequence: MVIVMKVAITSGAAEGPTKLNAFDNALLQAGIGDVNLIKVSSILPRNTRIVELPELEPGSIVNCVLSHMVSERRGDLISAAVAVATSSDFGCVVENSSVNRDPEDVRSEAISMVRYMMSVRGLEIKELIVEETNHVVEKCGAAVSAVVYLD
What are the official names of this protein?
Pyruvoyl-dependent arginine decarboxylase, PvlArgDC.
What is the protein family that this protein belongs to?
Belongs to the PdaD family.
Protein: FABA_TERTT
Sequence: MQDFVPNSSYTREELIACGNGELFGPGNAQLPVPNMLMLDRIAHISTTGGEYGKGEIIAELDIHKDLWFFGCHFPGDPVMPGCLGLDAMWQLVGFFLAWKGNPGRGRALGSGEVKFTGQILPTAKQVTYHIHLKRVIERKLIMGIADGRVAVDGKEIYFAKDLRVGLFSNTDTF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_STRPZ
Sequence: MAKVCYFTGRKTVSGNNRSHAMNQTKRTVKPNLQKVTILVDGKPKKVWASARALKSGKVERI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: CRTM_STAA3
Sequence: MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDSIDVYGDIQFLNQIKEDIQSIEKYPYEHHHFQSDRRIMMALQHVAQHKNIAFQSFYNLIDTVYKDQHFTMFETDAELFGYCYGVAGTVGEVLTPILSDHETHQTYDVARRLGESLQLINILRDVGEDFDNERIYFSKQRLKQYEVDIAEVYQNGVNNHYIDLWEYYAAIAEKDFQDVMDQIKVFSIEAQPIIELAARIYIEILDEVRQANYTLHERVFVDKRKKAKLFHEINSKYHRI
What is the function of this protein?
Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress.  Catalyzes the head-to-head condensation of two molecules of farnesyl diphosphate (FPP) into the colorless C(30) carotenoid 4,4'-diapophytoene (dehydrosqualene).
What are the official names of this protein?
4,4'-diapophytoene synthase, DAP synthase, C30 carotenoid synthase, Dehydrosqualene synthase.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family. CrtM subfamily.