PharMolix/UniProtQA huggingface dataset:
Protein: IOLG_RALSO
Sequence: MTLQIGVIGCGAIGQDHIRRLTRTLSGARVVAVTDIDPTQAHAAVANHGLNAEVYANGGDLIEAPDVQAVLVTSWGPTHEEFVLKAIAQGKPVFCEKPLAVTADGCMRIVAAEQAHGSRLVQVGFMRPYDAGYRALKQVIDSGTIGAPLMLHCAHRNPSVGDRYMTDMAITDTLIHELDVLRWLTGDDYVSAQVVYPRKTRHASSHLADPQIVLLETAQGVRIDVEIFVNCQYGYDIQCEVVGENGIATLPDPQAVSLKHAARHAIAILTDWKDRFIAAYDIELQAFIDGVQGGALTGPSAWDGYAAAVAADACVRAQKSGAIERIEMAARPAFYRG
What is the function of this protein?
Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
What are the official names of this protein?
Inositol 2-dehydrogenase, Myo-inositol 2-dehydrogenase, MI 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: PURA_PENRW
Sequence: MVSIVLGSQWGDEGKGKITDMLSQDATLCCRAAGGHNAGHTIVHEDVTYDFHILPSGLVSPKCINLIGAGTVFHVPSFFKELAAIEAKGLKGAAQRIFVSDRAHVCFDLHSVVDGLEEKGLGGRKVGTTGKGIGPCYSDKAARRGVRVGEILDEETFERKLRTLDTSYRTRFGDLAYDVEEEIARFKEYRNLLKPHIVDQLEFLQEHKNSPNTLVEGANALMLDLDHGTYPFVTSSSTGLGGAVQALALNPASIKSVIGVVKAYTTRVGSGPFPSEQLNGDGEKLQQVGREFGVTTGRRRRCGWLDLVLCRYSHAINHYTALNLTKLDILDDFDEIKVGVAYILPDGKRTTGTFPADPNVVDKIQVEYVTLPGWKSNTMGVKRYEDLPPNARAYIEFIEREIGGVPVKWIGTGPARDHMIARD
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUSTY_CHICK
Sequence: MEGEGAPSWRGGPGGLIRELCRSFGHYNRHLARLQHNLRETKKFFRDVKYSQGNLFASGAAIGEGSPSGAGGGGTRDGGQNFISFPRHEEEHLQQTVSWHPCLLILGQNCNAKCQLLNILLGEKLLPTTKISSEENCKRRRIRFTHGTQTRVSLALPEQYELVHMMAAHRGHWDTIPEEDLEIRGDSEDPAHRIAELEVVLPYSLLKEVDVVVAPCRGFQSAEATLEEYMNQVLLIVIFAISEAELSSSDENELREIKEKFSLPIFFFKVPESGVELISPKKTDNEKSSLYCQLMDLEYLSTNHCSCGAPSPDAVAQSMLVEQLEKLRLLSTFSRQVLQKHLVEAATSLNEVHCRCLNIFINQAFDMQRDLQITPKRLEYTRRKENELYESLMNIANRKQEEMKDMIIETLSNMKEELLEDAANMEFKDIIIPENGEPVSSKDIKCCIKQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLKSLEESWEVSVHPARSLEKSKDVSVHITSNYLKQILNAAYHVEVTFHSGSTVTRMLWEQIKQIIQRITWVSPPAITSDWKRKVAQDAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEDGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHGKPKLGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLQSHERLVDLHGSVIDYGYGGGSSIAVLLIMERLHRDLYTGLKAGLELETRLQIALDVVEGIRYLHSQGLVHRDIKLKNVLLDKKNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGHVKLPEAFERCASKDHLWNNVRRGVRPERLPVFDEECWQLMEACWDGDSSQRPLLGIVQPMLQGIMDRLCKSSSEHPNKGLDDST
What is the function of this protein?
May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation.  May induce both caspase-dependent apoptosis and caspase-independent cell death.
What are the official names of this protein?
Dual serine/threonine and tyrosine protein kinase, Dusty protein kinase, Dusty PK, Receptor-interacting serine/threonine-protein kinase 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction.
Protein: PFKA_UREPA
Sequence: MNQVNFLNLDKNILIITSGGDAPGMNASLISLIHRLMNNNFNVFIGIEGLLGLYNNLIEPIKDKRVFDVYFNEQGTVIKTSRFIKLDINDKKTQIIKDNLLSHNIQKIIILGGQGSMQAGLVLTKMGFEVFGILHTIDNDFSETQMCIGALSAASFNQKLLKCLNYTAKAHCAFNLVELMGRECSWLVNNSVGKLKPILMLTNQDNKYTVDEVIDLIKDKINSIKEYDPLIIVQELIYDQKWYELLVKTFEQKLHKSLRITILNYLQRGAPVSDFDLQLAKDSANVLVDFIVNQNDIKNTNNMYVVINKFDNKLEVIKFNK
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
Probable ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_HISS2
Sequence: MAERKYFGTDGVRGKVGSYPITPDFVLKLGWAAGKVLATQGTGKVLIGKDTRISGYMLESALEAGLAAAGLSAAFTGPMPTPAIAYLTRTFRSEAGIVISASHNPFYDNGIKFFSAQGTKLPDDVEEAIEAMLEQPMDCVESAKLGRASRINDAAGRYIEFCKSTFPAHLSLDKYKIVVDCANGATYHIAPNVMRELGAEVIEIGTQPDGMNINENCGATDIKALQNQVLETKADIGLAYDGDGDRLIMVDHFGNKVDGDQILFIIAREALRSGNLKGGVVGTLMSNMSLELALKQLGIPFVRANVGDRYVLEKMQEYNWILGGENSGHIIIADKNTTGDGVIASLAVLAAMVQHKLSLNELASAVKLFPQVLINVRFAGGANPLESDAVKAVATEVEKQLAGKGRILLRKSGTEPLIRVMVECEDAELAQLSAEKIAEAVRSN
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MURI_CLOBM
Sequence: MNINDKPIGFFDSGVGGISVLKEAFKLLPKEDFLYYGDSKNAPYGTKKVEEVKTLTFNATDFLMNKGIKALVVACNTATSVTINDLRENYDIPIIGIEPALKPAVELKKGGKIIIMATPMTLAEKKFANLMDLYKETEDIEPLPCPGLPELIEQGIVSGDVIYNYLKDKFSKYDNEKISSIVLGCTHYPFIEETLKEVTHNKACIIDGSFGTSRELKRQLKNSNMLREENRVGKVTIFNSREDRDIIDLSYKLFNMK
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: SCN3B_RAT
Sequence: MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE
What is the function of this protein?
Modulates channel gating kinetics.  Causes unique persistent sodium currents.  Inactivates the sodium channel opening more slowly than the subunit beta-1.  Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
What are the official names of this protein?
Sodium channel subunit beta-3.
What is the protein family that this protein belongs to?
Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CYF_PROMA
Sequence: MRRILTFFLGSIIIGLSIIISPSSSFAYPFWAQQNYENPREATGKLVCANCHLAKMTTQVEVPQSVGADSVFKAAVKIPYKPGTEEIGADGSKVPLQVGAVVMLPDGFKLAPQDRWTEDIKEETKGVYFTQYSEEKDNIILVGPLPGDQNKEIVFPILSPDPAKDKNIHFGKYSINVGGNRGRGQVYPTGEKSNNSIFTSTAAGLISTIEPNKDGGTNITIQTESGEAIIEEIPVGPSLVVKEGQTIDIGIPLTSDPNVGGFGQLDTEIVLQSPARVIGLIAFFAGVALTQILLVLKKKQVEKVQAAEGI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: GRPE_COXBN
Sequence: MSSKNNPESETKAKNKWEKVMEAEEEQEEGGGDGSQEMEPHREGLEFPSREKLEGQLTRMEHKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDLLPVADSLIHGLESPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVINPNPGDPFDPALHEAMSVQAVPDAKPDTIIQVLQKGYQLNGRVLRAARVIVAG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_CHLPD
Sequence: MDQLKKPHILLCNDDGIEGEGLHALAASMKKIGNITVVAPAEPHSGMSHAMTLGTPLRIKKYYKNNRFFGYTVSGTPVDCVKVALSQILPSKPDLLVSGINYGSNTATNTLYSGTVAAALEGAIQGITSLAFSLATYENADFSYAAKFARKLSKKVLTEGLPPDTILSVNIPNIPESEIQGILVTEQGRSRWEEDAIERHDVYGNPYYWLNGTLMLLDTSLQHDEYAVRKHYVAVTPISCDFTNRDFMGSLEQWNLKK
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCDH_STRCO
Sequence: MTSPENVRRVACVGAGVIGGGWVAHFLARGYEVTAWDPAPDAEPRLRRLVEAAWPTLTRLGLAEGASTDRLTVTDTLEQAVADAEFVQESAPEKLDLKRDLLARLDAATPPGVVIASSTSGYPMTDMQTTAADPSRLVVGHPFNPPYLIPLVEVVGGERTAAAAVAWASRFYEVAGKSVITMDNEVPGFIANRLQEALWREALHMVASGEATVRDIDLSITEGPGLRWAVMGPMLTFALAGGEGGMAHMLDHFGPSLKSPWTRLAAPELDKELYDAVVAGCDEAADGRSIADLVAERDRGVVEVLRATGRLGPEEDSR
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.
What are the official names of this protein?
L-carnitine dehydrogenase, CDH, L-CDH.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLHL3_BOVIN
Sequence: MDGESIKPSSQPLIQTGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWTYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKPL
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron.  The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity).  The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity).
What are the official names of this protein?
Kelch-like protein 3.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
Protein: Y561_CHLPN
Sequence: MACEQHEGCYELEEREEIEDIKDSDTKWVSITQAAKLHNVTRQAIYVAIKQKKLKASKETRWEIDIKDLEEYKRNRYSRKKSLYQGELVFDNGKGCYSINQVAQILGIPVQKVYYATRTGTIRGERKGAAWVIHVSEIERYKNEYLSKQAAKKLKGAEPKEHQAPNFEPPTEIFPESN
What are the official names of this protein?
Uncharacterized protein CPn_0561/CP_0189/CPj0561/CpB0583, EUO.
What is the protein family that this protein belongs to?
Belongs to the EUO family.
Protein: RL7_TREPA
Sequence: MAALSNEQIIEAIRGKTILELSELIKAVEEEFGVTAAVPVAPVAEGGGAGSVAAEEQTEFTVVLKGLAEPGKKIAVIKEVRNVISGLGLKEAKDLVEGAPKTLKENVSKEEAAKIKESMTAAGALIEIS
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: GATB_METRJ
Sequence: MNAPVDPKKLIKGGLHDWEVIVGMEIHAQVSSRAKLFSGASTEFGAEPNDHVSLVDAAMPGMLPVINAECVAQAVRTGLGLKAKINLRSVFDRKNYFYPDLPQGYQISQYKDPIVGEGEVLVDLADGASITVGIERLHLEQDAGKSLHDQDPTRSFVDLNRSGVALMEIVSRPDLRSSEEAKAYVTKLRTILRYLGTCDGDMEKGSLRADVNVSVRRPGEPLGTRCEIKNVNSIRFIGQAIETEARRQIAILEDGGTIDQETRLFDPTKGETRSMRSKEEAHDYRYFPDPDLLPLEFDQAYVDALAEGLPELPDAKKARFVSAFGLSPYDAGVLVAERASADYYEAVAKGRDGKAAANWVINELFGRLNKEGLSIEATPVSADQLGTIIDLIGEGVISGKIAKDLFEIVWTEGGDPRVVVESRGMKQVTDTGAIEAAVDQIIAANPDKVAQAKEKPTLLGWFVGQTMKATGGKANPAAVNALLKAKLGIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: RSMF_ECOK1
Sequence: MAQHTVYFPDAFLTQMREAMPSTLSFDDFLAACQRPLRRSIRVNTLKTSVADFLQLTAPYGWTLTPIPWCEEGFWIERDSEDALPLGSTAEHLSGLFYIQEASSMLPVAALFADGNAPQRVMDVAAAPGSKTTQIAARMNNKGAILANEFSASRVKVLHANISRCGISNVALTHFDGRVFGAAVPEMFDAILLDAPCSGEGVVRKDPDALKNWSPESNQEIAATQRELIDSAFHALRLGGTLVYSTCTLNREENEAVCLWLKETYHDAVEFLPLGDLFPGANKALTEDGFLHVFPQIYDCEGFFVARLRKTQAIPVLPAPKYKVGNFPFSPVKDREAGQIRQAAASVGLNWDENLRLWQRDKELWLFPVGIEALIGKVRFSRLGIKLAETHNKGYRWQHEAVIALASPDNVNAFELTPQEAEEWYRGRDVYPQAAPVADDVLVTFQHQPIGLAKRIGSRLKNSYPRELVRDGKLFTGNA
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_LEPIC
Sequence: MLEKIYLANPRGFCAGVKYAISYVEQVQANSEEQIYVRKEIVHNRRVVEDMKKNGIRFINDLDEAPNGATVIFSAHGVSPSVVEAAKQRGMKIGDATCPLVTRVHRKARKIKDTHQIIYIGHEGHDEAIGTMGEAEMFLVESLEDIISLKDKIDPNKPLTYLMQTTLSVADTKNIIDQISKTFPFVEHPSKDDICYATTERQEAVSLMMDKIDAMLVIGADNSSNSLRLLQLAQKSKPHSFKVSTADDLSKEYIQNNEIKILGLTAGASTPQVLVDEIISKLKIFYPNANVELFPGSRDDSMNFKLPGVLLS
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: NANE_MYCCT
Sequence: MDLINQIKNTLIVSCQAIGDEPLNDSYVLSKMAYALVLGGSKVLRLSQVEHIKAVKQVVDVPIIGLIKKHYDNSEVFITPTIKEVDQLVDLKVDIIALDATLRTRPDQDLTNLVKTIKTKYPNQLLLADCSSVEDAINAQNLGFDLIASTLRGSTKQTKGHNNLENNYQFLRDLKKVITKPIIAEGGIWTPQQAKEILNLGIHSVVVGTAITRLHSIVKYWNDILK
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: YIDC_NITEC
Sequence: MDNKKIVLLIIFSTSLLFLWDAWVKEQEKFNAPPSVVAQANSAAGVTQSKNNDGLPIPGSELTASQTGSDLNGIPSSGDTADSVTPRLLPSGEQIRVVTDKVIAEIDTMGGDLRRLELLQQPSPEDENVPYSLLHSEASRTYVAQSGLVGEGLPNHKTVYQVESGIRNYELTAGEDKVVIRLLAPETQGVQVIKTYTFHRDSYVIDIGFEIANKSDATIRPFAYFQMLRDDTPPPAHTMMIRSFLGAAVYTDEEKYQKIPFDDLDKGKTDYPANANNGWIAMLEHYFLTAWLPPQQTPREYFAKRQSDNLYTAGVIVPAGVITAGETVTTTMPLYAGPEEQDRLAELAPGLELTVDYGWLTMIAKPLFRLLSFYHSWTGNWGIAIILLTITVKLLFFPLSAAGYRSMAKLRLVTPKLKRIQDQYKGDRQRMHQAMMDFYKTEKINPMGGCFPILVQIPVFIALYWTILAAVELRYAPFALWITDLSSPDPKYLLPVLLGISMFIQTRLNPTPTDPIQAKIMQIMPVAFSAIFFFFPAGLVLYSLVNNILSIAQQWKITKMYGTAPSQDAPESPASKDAPELPVSNQVINDSENTEAPASGPADSPKKPVNIPRRMHKRTRKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRPE_CAMJR
Sequence: MSEQKQEIENENAQNSENLQDDLQDNEKNETNELQKELEELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVNVECQDEISLKIKEGVQNTLDLFLKKLEKHGVALIKDEKEFDPNLHEAMFHVDSENHQSGEVVQVLQKGYKIADRVIRPTKVSVAK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GBP4_HUMAN
Sequence: MGERTLHAAVPTPGYPESESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRLLKILDMASNIMIVTLPGASKLLGVGTKYLGSRI
What is the function of this protein?
Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity).  Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (By similarity).
What are the official names of this protein?
Guanylate-binding protein 4, GTP-binding protein 4, GBP-4, Guanine nucleotide-binding protein 4.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Golgi apparatus membrane. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi apparatus.
Protein: HPF_HAEI3
Sequence: MRNSFKIMTALALGLFAMQANAKFKVVTTFTVIQDIAQNVAGNAATVESITKPGAEIHEYEPTPKDIVKAQSADLILWNGLNLERWFERFFQNVKDKPAVVVTEGIQPLSIYEGPYKDAPNPHAWMSPSNALIYIENIKNALVKYDPQNAAVYEKNAADYAQKIKQLDEPLRAKLAQIPEAQRWLVTSEGAFSYLAKDYNLKEGYLWPINAEQQGTPQQVRKVIDLVRKNNIPVVFSESTISAKPAQQVAKESGAKYGGVLYVDSLSAKNGPVPTYIDLLNVTVSTIVKGFGK
What is the function of this protein?
Part of an ATP-driven transport system for iron.  Metal-binding component (Potential).  Acts as an adhesin that promotes binding of H. influenzae to host laminin and vitronectin.  In addition, interaction with serum vitronectin plays an important role in bacterial serum resistance.
What are the official names of this protein?
Putative metal ABC transporter substrate-binding protein Hpf, Surface-adhesin protein F.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 9 family.
What are the subcellular locations of this protein?
Cell outer membrane. Cell surface.
Protein: FABH_LIMRJ
Sequence: MQNLRITSTASYHPPLNITNQQLSTIMDTSDEWIKTRTGIHQRYISNIENTSDLALNVGNQLLTNANLKTTELDLIIIATMSPDAYTPSTAAIVQGELGAKNAIAFDISAACTGFIYAMNTAELMLKSSNWQNAMVIGAEVLSKLIDWKDRSTAVLFGDGAGGVLLQKTTTATPLILGRDLHTFGDLGDKIVAGKTTPKAGFPKQLTSLSPFAMAGRDVYRFATHEVPRSIASAVQQANLKLDDIDYFLLHQANERIINQIAKRLGQPITKFPMNISEYGNTGAASEPILLTQAVAHELVKPGNIIAMSGFGGGLSTGTIILNY
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GOP_BPP4
Sequence: MLNHVYGLIGVVGTIITIATSFIRNQDISQWLLVCSGWLAALLIGWFTHRTIKAISNNHTNVIKSNMEVINSHNESNQNLMAENKELIKELARTSEQKEKMESIAAYLATQNPQINAMPRTASRPENIDSEAN
What is the function of this protein?
This protein kills E. coli when the beta protein is absent.
What are the official names of this protein?
Protein gop.
Protein: PP1RB_XENLA
Sequence: MAETSGPTAAGGSTSSTVTTESETQPEHRSLTLKLRKRKPDKKVEWTCDTVDNENLGRRSSKCCCIYEKPRPFGESSSESEDDDDCCESAHCIRGHKKATSGSKETPSSHHDKTGSMQH
What is the function of this protein?
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome.  Inhibitor of protein phosphatase 1.
What are the official names of this protein?
E3 ubiquitin-protein ligase PPP1R11, Protein phosphatase 1 regulatory subunit 11.