PharMolix/UniProtQA huggingface dataset:
Protein: KHSE_STAA2
Sequence: MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPILCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGFYNDVSKETSVAHIDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDEVKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SV2B_RAT
Sequence: MDDYRYRDNYEGYAPNDGYYRGNEQNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVKSKQTKMAPSRADGLRGQADLMAERMEDEEQLAHQYETIIDECGHGRFQWTLFFVLVLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGLIVYLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSHIKTPKQMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILAVVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQHGKLVNDKFIKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFIDCRFINSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKLGAILGNTIFASFVGITKVVPILLAAASLVGGGLVALRLPETREQVLM
What is the function of this protein?
(Microbial infection) Receptor for C. botulinum neurotoxin type F (BoNT/F); binding requires glycosylation of this protein (PubMed:19476346, PubMed:19650874).
What are the official names of this protein?
Synaptic vesicle glycoprotein 2B, Synaptic vesicle protein 2B.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin- secreting cells of the pancreas (PubMed:16306227). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (PubMed:12754292).
Protein: DOXA_STRS5
Sequence: MSGEAPRVAVDPFSCPMMTMQRKPEVHDAFREAGPVVEVNAPAGGPAWVITDDALAREVLADPRFVKDPDLAPTAWRGVDDGLDIPVPELRPFTLIAVDGEDHRRLRRIHAPAFNPRRLAERTDRIAAIADRLLTELADSSDRSGEPAELIGGFAYHFPLLVICELLGVPVTDPAMAREAVGVLKALGLGGPQSAGGDGTDPAGDVPDTSALESLLLEAVHAARRKDTRTMTRVLYERAQAEFGSVSDDQLVYMITGLIFAGHDTTGSFLGFLLAEVLAGRLAADADGDAISRFVEEALRHHPPVPYTLWRFAATEVVIRGVRLPRGAPVLVDIEGTNTDGRHHDAPHAFHPDRPSRRRLTFGDGPHYCIGEQLAQLESRTMIGVLRSRFPQARLAVPYEELRWCRKGAQTARLTDLPVWLR
What is the function of this protein?
Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers.  In vivo, DoxA catalyzes the C-13 hydroxylation of 13-deoxycarminomycin and 13-deoxydaunorubicin to yield 13-dihydrocarminomycin and 13-dihydrodaunorubicin, respectively, as well as the oxidation of these 13-dihydro-anthracyclines to their respective 13-keto forms, carminomycin and daunorubicin.  In vitro, it also catalyzes the C-14 hydroxylation of daunorubicin to form doxorubicin (adriamycin), although this strain is not a doxorubicin producer.  It is not able to accept anthracyclinones (aglycones) and anthracyclines with a 10-carbomethoxyl moiety.  13-oxidation of the anthracyclines possessing the 4-methoxy substitution is greatly favored.  The anthracycline analog desacetyladriamycin can be oxidized to 10-hydroxydesacetyladriamycin.  It can only use NADP.  DoxA acts jointly with DauV.
What are the official names of this protein?
Cytochrome P-450 monooxygenase DoxA, 13-deoxycarminomycin C-13 hydroxylase, 13-deoxydaunorubicin C-13 hydroxylase, 13-dihydrocarminomycin C-13 hydroxylase, 13-dihydrodaunorubicin C-13 hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_QRFVE
Sequence: MERLNSFLVSTLIRDGMSREEKEKLVGPYPVGIENTGLGAVSFLYKYVNVPPLAVGAPAPKTAESVLRSFEYNRLPDNGKGLRPRQYWMETDGPYPYDVTCANFHLSAAQEMHKSFLREHHAVIDKVTEAMYQRLKTTNADILTKGKQTWDPINKRSVPSAAAFKEITTVLRTYLKLVGFSVLDFVEAFHRMLMLPEMVYNRRVNAEKTVRKRKGGVITLEKKAVVVLETVHLTRNEDVRETVMGWATAFCSYLKSKERGKLKRRAIASANPILRMFLWIVEELHLELGKQEEMVSSTISIGGEEKRAKIIATPDGLSLNEFNIQATEDATKWNECLAPENFCLMHEIWWSHSIREEMGLPKPPESAEIMRQIFQQAFYLLSHKRIYLGKGHLIHNQTRAALLQWKEDHEKYMNEKTLEWFRKIKEHLDSEGYVKAPFGMLMGMLNAGSTTLALPATKWRLQPGMDCKTVRSSDDSMTVFSGKTRQLLMENINRFYDNLKLLGINISQKKTRFFQLKFGEYTSAYQDGDFTAQYGVGTAALRPEGSNPPDDFHSVASQTATSLRSGTVNFVGAQFRLGIGVDNVRRLYKIDRTPGKRQGVPDSALVLSDGGPSPWNFSNCHLPELALKWITHEQNPQATRYLERVMNPNNPFTADAAEITSFSRELNTLVETSLELPRNLFHTLKRFNATQKSLLRKGDNDFMKSCNLAMQLFEEVIPASLLQVPSGPQPMSQVMADVLRAQASALRSVGVHFTEEEMEEIRGALNTLEHDSNIDFE
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
Protein: PNP_RHIEC
Sequence: MFDTHTVEIEWAGRPLKLETGKIARQADGAVLATYGETVVLATVVSAKAPKPGQDFFPLTVNYQEKTYAAGKIPGGYFKREGRPSENETLVSRLIDRPIRPLFPEGYKNDTQVVVTVVQHDLENNPDILSMIASSAALTLSGVPFMGPVGGARVGYINGEYVLNPHLDEMDESSLDLVVAGTYDAVLMVESEAKELPEDVMLGAVMFGHKGFQPVLDAIIKLAEVAAKEPRDFQPEDYSELEGEMLKHFEAELREAYKITQKADRYAAVDAVKAKVKAHFLPEEGEAKYTAEEVGAIFKHLQAKIVRWNILDTKSRIDGRDLETVRPIVSEVGLLPRTHGSALFTRGETQAIVVATLGTGEDEQYVDSLTGMYKERFLLHYNFPPFSVGETGRMGSPGRREIGHGKLAWRAIRPMLPSAEQFPYTLRVVSEITESNGSSSMATVCGTSLALMDAGVPLAKPVAGIAMGLILEGDRFAVLSDILGDEDHLGDMDFKVAGTADGITSLQMDIKIAGITEEIMKVALGQAKGGRAHILGEMAKAITESRGQLGEFAPRIEVMNIPVDKIREVIGSGGKVIREIVEKTGAKINIEDDGTVKIASSSGKEIEAARKWIHSIVAEPEIGQIYEGTVVKTADFGAFVNFFGARDGLVHISQLASERVAKTTDVVKEGDKVWVKLLGFDERGKVRLSMKVVDQATGQEIPNEKKKEEAAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WSD2_ARATH
Sequence: MAIERQVTEAEEPVSPFARLFSLPGLDVFNIVTIGCKTEGNASTIVEGIKNTLINHPRFSSILVTGHGEHKGKARWIPTKINVEEHVIVPDIDPNIENPDEFLEDYTSNMALSPMDMSKPLWEFHLLKLKTSHAEAVTVARFHHSLGDGMSLMSLLLACTRKTCDPEAFPTFVAPKKNKAKNVCFSLVAWLWFIVRLMFHTCVEVIKSIVFICRASDTSAHIMGKPGATLSANKFIHRIISLDDVKMVKNAMNMTVNDVLFGMVQAGLSRYLNQRYDLETSSKSRKNLHNIGLHGVVFFNLRPNRNIEDLAKMMAKGSKCRWGNSIGYVLIPLGMKPQDDVFEYVRQAKTIMDGKKHSLEPLFSYGLLKVTMEVFGLRGLKTLVKRIFGSTTMIFSNVVGPDEEISFFGHRIAYIAASTFGVPQALNICIQSYVDKLIINIGVDVDVIPDPHHLCDLIIEALRMMNSAAPKKVFHASKV
What is the function of this protein?
Bifunctional wax ester synthase/diacylglycerol acyltransferase (By similarity).  Involved in cuticular wax biosynthesis (By similarity).
What are the official names of this protein?
Wax ester synthase/diacylglycerol acyltransferase 2, WS/DGAT 2, Diacylglycerol O-acyltransferase WSD2, Long-chain-alcohol O-fatty-acyltransferase WSD2.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the long-chain O-acyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: SYI_VIBVY
Sequence: MSEYKDTLNLPETGFPMRGDLAKREPEMLKRWYQEDLYGEIRKAKKGKKSFVLHDGPPYANGDIHIGHALNKILKDIIIKSKTLSGFDAPYVPGWDCHGLPIELMVEKKVGKPGQKVTAAEFREKCREYAAGQVEGQKESFKRLGIMGEWDKPYRTMDFTTEANIIRALGQIADNGHLLKGFKPVHWCTDCGSALAEAEVEYKNKVSPSIDVRFKAADEAALLAKFSLNEGHQGQGDVSIVIWTTTPWTLPANRAVCLRDDLEYVLIQVEGDNPERIIVAAELAKDVMDRAGIEHFHNLGFAKGADLELTQFQHPFYDFTVPAILGDHVTTDSGTGVVHTAPGHGQEDFAVGQKYNLEVANPVGSNGVYLPDTELFAGQHVFKANDAVVETLKEKGALLHHHAYEHSYPHCWRHKTPIIFRATPQWFVSMDQAGLRAKALESIKGVQWMPEWGQSRIEGMIEGRPEWCISRQRTWGVPIALFVHKETAELHPNTSELIEKVAQVVEQKGIQAWWDIDAAELLGDDAAQYEKVLDTLDVWFDSGVTHYAVVDKREEFNGAEADMYLEGSDQHRGWFQSSLISSIAMKGKAPYKQVLTHGFVVDGHGRKMSKSIGNVVAPKDVTNKLGADILRLWVASTDYTGEVAVSDEILKRSADAYRRIRNTARFFLANLNGFNPETDIVPVEEMVALDRWAVGRALAAQNEIVKAYDEYNTHAVTQRLMHFCSIEMGSFYLDVIKDRQYTAKLGGHAQRSCQTALYYIVEALVRWMAPIMSFTADEIWNQMPASLPSGESRDKFVFTGEWFDGLFGLAEGEELNNAFWSEMQKVRGAVNKLLEAARSDKTIGGSLQAELTLFADDALAAKINKLEDELRFVLLTSAATVKPLSEKSDAAQATDIEGLFVEVRATEAEKCDRCWHHTPDVGTIEGHEKICGRCVSNVDGEGEARKFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRK1_SCHPO
Sequence: MRFKSIQQNIEDEGKVNVREVNPDSYAERDHGYTAGIFSDAEENFGITQQVADSTQNPTSKPKSRHAHFHETVHENPSEYSRSKCKQPTNEKEYDKAIEALVAKAIVEEHSGQQFPVYKGLEQYTLLQKMGDGAFSNVYKAIHNRTGEKVAIKVVQRAQPNTDPRDPRKRQGVESHNILKEVQIMRRVKHPNIIQLLEFIQTPEYYYLVLELADGGELFHQIVRLTYFSEDLSRHVITQVAHAIRYLHEDCGVVHRDIKPENLLFDSIDFVPSRVRKYRAGDDPDKVDEGEFIPGVGAGTIGRIRLADFGLSKVVWDSHTQTPCGTMGYTAPEIVRDERYSKGVDMWALGCVLYTILCGFPPFYDESISLLTKKVSRGEYSFLSPWWDDISKSAKDLISHLLTVDPESRYDIHQFLAHPWISGSREPTFPATDAPNTAQRENPFTYDFLEPEDVAAAGSAARTPGVNSLREVFNISYAAHRMEQEKIRKRGQRGNQGIMNFMGDMDDLMEENDDYDDGTKSVEHSMKRVNLSGENDPSLASRQPAQSQQQSSQRSRNKFKGFQLNLSKATLYNRRHRQKV
What is the function of this protein?
Delays the mitotic G2/M transition by promoting nuclear exclusion of cdc25 (PubMed:15629716, PubMed:12080074).  During osmotic stress, inhibits the G2/M transition in a sty1 stress-activated MAPK pathway-dependent manner (PubMed:15629716, PubMed:12080074, PubMed:12589433).
What are the official names of this protein?
Serine/threonine-protein kinase srk1, Sty1-regulated kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Spore core. Note=Translocates from the cytoplasm to the nucleus during environmental stress in a sty1-dependent manner.
Protein: TIM22_BOVIN
Sequence: MAATAPKAGGSAPEAAASAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIERAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGLKAGVIGCGGFAAFSAAIDYYLR
What is the function of this protein?
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel.  Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim22.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CANB_CAEEL
Sequence: MGADASLPMEMCSNFDAYELRRLTRRFKKLDVDGSGSLSVEEFMSLPELQQNPLVQRVIDIFDEDGNGEVDFREFIQGISQFSVKGDKNTKLKFAFRIYDMDRDGFISNGELFQVLKMMVGNNLKDSQLQQIVDKTILFHDKDGDGKISFQEFCDVVEHTEVHKKMVLENI
What is the function of this protein?
Regulatory subunit of tax-6/calcineurin A, a calcium-dependent, calmodulin-stimulated protein phosphatase (PubMed:12221132).  Confers calcium sensitivity (PubMed:12221132).  Plays a role in egg-laying, fertility, growth, movement and cuticle development (PubMed:12221132, PubMed:12684004).  Plays a role in sensitivity to CO2 levels (PubMed:18524955).  Regulates expression of tax-6 inhibitor rcn-1 (PubMed:12684004).  Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine (PubMed:15990870).  Negatively regulates lifespan (PubMed:19279398).  Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle recycling (PubMed:20803083, PubMed:21345307).  May negatively regulate autophagy (PubMed:19279398).
What are the official names of this protein?
Protein phosphatase 2B regulatory subunit cnb-1, Calcineurin subunit B.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOD_KLEP3
Sequence: MATPHINAEMGDFADVVLMPGDPLRAKHIAETFLEDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVREDVKLRDVVIGMGACTDSKVNRLRFKDHDFAAIADFGMVRNAVDAAKALGVDARVGNIFSADLFYTPDPSMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDKE
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: PPN2_YEAST
Sequence: MEDKRKRRAATLSTALILFVACCVYTLYIFKFDNPRLSPPVSLLPTISTLKKIEHVTDLNKEYVFVGDVHGNYDEFIELIDDKIGGLGENITMILLGDFIHKGPDSDKVVSYILNHKDQVKCVLGNHEILVMMAYLNPDFSKWVRRPKLMTPLTFSTETNFIPQDISKISNAHGRLARELGFSKLSQLAEHCSMAIELDLDITGDILFGAHAGMVPGDFMKPNQIPGVSSLSNMKYVDKKNWSKTSREKENKNYVRWYTLWDKYGDHFSNAKVFYGHDASMGLNLRRQTKGLDTACIKNNLLSSMKVKYDIKKGQYDYELIQVQCS
What is the function of this protein?
Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.  Exclusively shows endopolyphosphatase activity, cleaving inside the polyP chain.  Together with PPN1, responsible for a substantial fraction of polyphosphatase activity that is necessary to mobilize polyP stores in response to phosphate scarcity.
What are the official names of this protein?
Zinc-dependent endopolyphosphatase, Vacuolar polyphosphatase PPN2.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily.
Protein: QUEA_BAUCH
Sequence: MHVADFSFNLPKNLIARYPLPERSTCRLLSLDGHSGAIKHNVFTDILDQLSLGDLLVFNNTRVIPARLFGRKISGGKVEVLVERVLDNQRVLAHIRASKTPKIDTLLLLGDNENIRAIIVARHQIWFELLFDDQRDILTILNDAGHIPLPYYLDRPDYSLDRELYQTVYSQHPGAIAAPTAGLHFDQQLLSALRVKGVEMVFITLHVGTGTFQPIKVKKIEHHHMYSEYTEVPHTVVDAVIACKSRGNRVVAVGTTSVRSLESAIVSVSNSKHTMLAPFCGETSIFIYPGYRFRVIDALITNFHLPQSTPIMLVSAFAGYQHTFNAYREAVNLAYRFLSYGDAMFITNNNSVF
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAA_RHOBA
Sequence: METLTASFFVRIASSIRAGYPTNMTDPIALVDRFGRRHDSLRISITDRCNIRCFYCMPEHDAEFLPRSGVLTFEEIERLAGLLVKRCGVRDIRITGGEPLVRRDCVDLIRMLARIDGLEDLSMTTNGMLLRDHAADLRSAGLKRLNVSLDTLDEATFVKIARRPGVDRVIDGIDAAIEAGFESIKLNALAIRGLSESELVGLVRFSIEKSVTLRFIEFMPLDSDRAWKSKDVLSGDACLKLLSEAFGDVTPTGRENPSAPAETFTLRCDGREGTIGIIRSVTRPFCGDCNRLRLTADGGLRNCLFSQSETPLRDAMRSGCDDDKLIQKIQQCVGEKHAAHGIDSDDFRPPERAMHAIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: RUVB_ECOK1
Sequence: MIEADRLISAGTTLPEDVADRAIRPKLLEEYVGQPQVRSQMEIFIKAAKLRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQYIVSRSARFMGLEMSDDGALEVARRARGTPRIANRLLRRVRDFAEVKHDGTISADIAAQALDMLNVDAEGFDYMDRKLLLAVIDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATTRAWNHFGITPPEMP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CHLB_SYNJA
Sequence: MKLAYWMYAGPAHIGTLRVASSFKNVHSIMHAPLGDDYFNVMRSMLERERDFTPVTTSVVDRQVLARGSDEKVIRNIVRKDGEEQPDLIVVTPTCTSSILQEDLHHFVRQAQLSSRCDVLLADVNHYRVNELQAAERTLHQIVEFYINKARKSGELSGPPRRTERPSCNILGISSLGFHHAHDLRELKKLLQDLGIELNLVIPQGASVHNLKHLGRAWFNVVPYRELGPMTARYLQEQFGTPYVEITPMGVVETARFIRQIQQVLNEQGIPVDYEPYIQEQTLYVSQAAWFSRSIDCQNLTGKKAVVFGDCTHAAAITKILAREMGVHVVWAGSYCTYDGEWFQAEVGGYCDQVLLTEDHTRVADAIAQVEPAAIFGTQMERHVGKRLRIPCGVISAPMHVQDFPIGYRPFLGYEGANQIVDLIYNSFTLGMEDHLLEVFGGHDTKEVIHKSLSADSDLIWTREAQAELNKVPGFVRGKVKRNTEKFARERGLTEITLEVMYAAKEALGA
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: RS20_GEODF
Sequence: MANHKSALKRIKQTEKRTERNRHVRSTLRTFIKRVREAVAAKDANLAKEALAAAIPVIDGAASKGVIHSSNASRSVSRLTKLVNTLS
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: FEN1_DROMO
Sequence: MGILGLSKLIADLAPLAIRESEIKNFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKAGELAKRAERREEAEKALKVATDAGDEAEIEKFNRRLVRVTKEHSNEAKELLKLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSCKLLRYLTYSEARKMPVKEFSYDKVLQGLELTSKEFIDLCILMGCDYCDSIKGIGPKRAIELIKTYRDIETILENIDTSKYIVPENWNYQRARELFVEPEVTDASTIDLKWTAPDEDGLVQFLCGDRQFNEERVRNGARKLLKSKQSQTQVRLDSFFKALPSSPNATAAAKRKAEEIKKSANNKKAKTSGGSGAARGRRPK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: DEOC_PHOLL
Sequence: MTDLTAAAQRALSLMDLTTLNDNDTDEKVTALCHQAKSLAGNTAAICIYPRFIPLARKVLREQGTPEIRIATVTNFPHGHDDIDIALAETQAAIAYGADEVDVVFPYRALMASNEQVGFEMVKACKVACAEADVLLKVIIETGELKEASLIRKASEISINAGADFIKTSTGKVPVNATLASAEIMMKVIHEMGVGETVGFKPAGGVRTAEEAAQYLALADHIMGDKWVDARHFRFGASSLLGNLLNTLGHQGQKQSSHY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_MICAN
Sequence: MLTIALPKGALLNESIQIFQKIGLDFSAFLDSKNRQLQITDPTNQAKALLVRATDVPVYVEYGQAQLGIAGYDVLLEKSPDVANLIDLKFGYCRMSVAVPADSPYQSPLDIPHHGKVASKFVNCAKDYFRRLDIPVEIIPLYGSVELGPITGMSEAIVDLVSTGRTLRENGLVEIDELFASSARLIAHPLSYRLDRDQIYNWVEKLREPTTSMAKV
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBHB_NEIMB
Sequence: MNKSELIEAIAQEADISKAAAQKALDATTNAVTTALKQGDTVTLVGFGTFYVGERAERQGRNPKTGEPLTIAAAKTPKFRAGKALKDAL
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.