Protein: ATG2_CAEEL
Sequence: MTLSTFNRVWCKVMLQRYMGAWLDNNLSVDQLSLELANGCLELDNLDINTKAVSNGFLQCNIPLKLIDGYLGKIKIEIPWLSLMTDPTRMCIEDLQLTFRGAEVMKINDIETLTSMIESVLMGLSTDDMARSVYEEVSKENNVASELLGPDDTADSFSGFIDAVYSRFCLKIKHLTLRFETDPKNRSTMATALEIRVETITFMDEQMRSCEMDHTNATDLVTTQPHGVVSTTNLRKNLTFSGVTFHTDVFSQINNDGMGDEENVLITSMHIRREKAKQMSPTKSVQNSLHPEMFQSAMSDMDAFHSCYDKLTQDYCSPDQLETLRTAPAEPELFSAPIQCAEVVGDISCVFRIKNGANDVNYADVDESKVETDVFIKGINVFATPSQIEIVNRFFSSIVTPKELVVHEQGKPMSKEDYENMTKNMEPNQSNEPPMAGASFGGNWNVGEVFREFDDLKSIKEKEKSEKEKFKSLKASGNIKEEFTVNTHIGTVLMYIPHCDYMSSDYAQQHGGYANVLNYLKKESESFFKSIQGYSFMSKHGLANIRQQSDSFYPKDHLRIVGGSLGITSSCKRVGNVDSFLCRVVATHFDMLEYLTPESAPENSTPIRIGLLDYSEQENLESDPNFKMVLSTSSEQKGLTKVDILLGAVKTELDFSIIDRISNLIACRPFFDEALTNYGNRNTVPQLKDDLYSDVLIAEDDVKSKTLVNLKCSNWQVDLRIPKADLRDPTGSRLPFSQRHVHNEFLRLGIKEIDVSIPIEKSVTLIEILCTEMIGDFCGEGLNIPKQQQRILHASKNGFDKINLKLTLCSDAKKLPGCGRKTSTSGIPDSMMKSVSADIMMAHPKKEGPFSKVPRSYCSHDGEETEEIIQAGTRKEILDFQEECQNFASTFMLFTVPVLKLHIPEKNFLEILYNRLVNDLALFQPAAPAFRNNQSTNSNVQPLESFQECVSPKNYAESEHSDLDDDVATLHESIESLNFDRDIPHTFVMTLNANKCTVLCNTAIKEAEKQPESSQVSLDLEKVHIGTTAGYHGDINHTYFHFTSSKAAAGSIDSPRAPRIPNLISAKDFGKWTKDCNQLEHVPITDELSSGSTEDAFAVALHMHFRPDVNMKDVLLGIALRNSQLQAKPFRHWGAFWITQLADLFTLQDYAIPGYELPSVSTDLHICFENAIIGYDHAWVNPNSKLKLRATLGQCNLASSIVSDMNISKTLCIFESCRLYMSNDLTKDAVRFEGYGTQKVSPKKFIPFLDLGSVQLDILFAVGDETGLRTNPTFEIRCQNDIINAWACADSLATFMKTVMEYTSHEQIPIKTPEEESQELMKSTKTDDINKSVAGESVWSDASTGSKHIQKMTVGANLPDDVEKRIQAMIQEAVNENDERDGIAIGEDAVREFATIQPKHDANETNESFEHVASRNFSVTDDEFCMVDDNIFGSGITIQPGESRTRPMPAKQLPEEPLINGSEFFQTIEDSGSDALYQTMSGQINPVLRYFLKDVTVRLSLYAGNDLSTSPSPIKTYCTEEYRNGFGPEQKIEQNSTGGPNRDHSAFVVFELSKITYLKQIFDKTAPMLSTTLFQVNDIVIKDCVRASDIKEMLYQYSVTNQPRRATAPIVTVRMSETHSKEGKMRVSMLPIKINVDQDTLEFLTDFFEETSKLLDLPKNQMSMPLIQRPVIEVPADIGSKKTTPKTSVSSSEGDIARMYPSIPSPSLTLEPLRPSPVQPPTPLGDLTYLEKISSNHQSPVKRPIIDAPLTASAVSIGKIFERDAHSDEDEEEIIDPIQMAAALEIRELNEELGRIEQLEKKKTDDLFKQSYSSSSSETESESSAPQSSQVRRLHESLDASNPTGLSDLTGDWADDHDLTYTHHDVVRQESPSFNCNISPIKGYSPPAELRPLNLMDSETERDSSASPVTSSPIKPARNIKKELPPLKMPRQPLSNDDILMRSTMMGSVHPSQSVHNLVDTSDDLEEHGNFLDSIDNEDDNEKQKIEEEMEEDEKEEEEERNKEIQEAVERGETFFKQFVFSPSVNIYVDYQGKRKITMEKAGALVGLLMAFGQLNQMPINLRKIDTRTGLLGTGRCMQHAIGEWSGDLLTNMPSVIASYGPISPLVQIGRGVVDLFLMPVAEFRKDDGNVMKGVQRGVGSFSVSSAAGIVGMAQTVTGFVQSLAEMTMKEIKPDDPSTRRVARRYNRNHGMNPTDVRHSLQLAYGILYDGYHQTRDDLELAAQEDRASGNSVVRSAFRYAVPTFLGPIVMATQVTYQLLGGLRNQLRPDTYQDERRKWGEKDVPGGVNK
What is the function of this protein?
Lipid transfer protein involved in autophagosome assembly and in the distribution of atg-9 and atg-13 during the autophagy-mediated degradation of protein aggregates (PubMed:21802374, PubMed:25124690).  Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity).  Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source to the IM for membrane expansion (By similarity).  Involved in autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes, which is essential for maintaining nucleotide homeostasis (PubMed:30102152).
What are the official names of this protein?
Autophagy-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the ATG2 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm.