PharMolix/UniProtQA huggingface dataset:
Protein: SYT_RUTMC
Sequence: MPIITLPDGTQKIFEQVVSVTQVAKSIGLSLAKAALAGEVDGQLVDTSFLIKTDANLAIITANDDKGLEIIRHSTAHLLAQATQMLYPKAQVTIGPVIDNGFYYDFVYKDGFSESDLAKIEKNMHKLVKQNLKIERFEMSRNEAIQFFKDKGEYYKTEIIESIPAGQTLSLYKQGNFIDLCRGPHVPLTAKLKAFKLMKLAGAYWRGDSNNEMLQRVYGTAWATKQDLEEHLHRLEEASRRDHRKIGKIQDLFHIQEEAPGMIFWHAKGWTLCQLIEQYMRGIFKDNDYQEVHTPQLIDKSLWEKSGHWEKFGDTMFTTSSENRDYAVKPMNCPAHIQIYNQGLKSYRDLPLRLAEFGSCHRNEPSGTLHGIMRVRNFVQDDGHIFCTPEQIQVEVSTFIDLTFAVYKHFGFDKVDIKLSTRPENHVGSDEVWDKAEAALAEALDAKVIKWEFQKGEGAFYGPKIEFVLKDCLERQWQCGTLQVDFSMPERLDAQFIDENNIKQTPVVLHRAILGSLERFVGILIEHYEGAYPCWLTPIQAVVINISGKQADFVIDITKKLKKQGLRVISDLRNEKIGFKIREHSLQRYPYILIVGDREMEKDQISVRQRGGKDLGVMSIEAFVEKINQEIL
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHI1_COCPS
Sequence: MRFLIGALLTLQTLVQASSMSSMPNYYPVPEAPAEGGFRSVVYFVNWAIYGRGHNPQDLKADQFTHILYAFANIRPSGEVYLSDTWADTDKHYPGDKWDEPGNNVYGCIKQMYLLKKNNRNLKTLLSIGGWTYSPNFKTPASTEEGRKKFADTSLKLMKDLGFDGIDIDWEYPEDEKQANDFVLLLKACREALDAYSAKHPNGKKFLLTIASPAGPQNYNKLKLAEMDKYLDFWNLMAYDFSGSWDKVSGHMSNVFPSTTKPESTPFSSDKAVKDYIKAGVPANKIVLGMPLYGRAFASTDGIGTSFNGVGGGSWENGVWDYKDMPQQGAQVTELEDIAASYSYDKNKRYLISYDTVKIAGKKAEYITKNGMGGGMWWESSSDKTGNESLVGTVVNGLGGTGKLEQRENELSYPESVYDNLKNGMPS
What are the official names of this protein?
Endochitinase 1, CiX1, Complement-fixation antigen, CF-AG, CF-antigen.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
Protein: EX1_BUCAI
Sequence: MIQFQKKTPNFLFYDYETFGIHTALDKPAQFACIRTDINLNIIDDPQYFYCFPSDDYLPDPGSVLITHITPQYTEKNGTNEYNFSQKIYDILMQSNTCVVGYNNINFDDEITRNIFYRNFFDPYEWSWKNGNSRWDILNLLRACYALRPTGINWPKNELGLTSFKLSDLTKTNNIVHLNAHNAVSDVYATIEIAKLVKKKQPRLFDFFFKIRKKNELYKLIDLRNFQPIIYISAYFGAIYHNMSCILPIAWHENNSNILIAIDLFKDIKTLINMCKKICFDSIFIKNLLDSGVVLLHLNRCPILAPIQVIRKEDYNRLNFHRFSLNKKIELIKKNMFFIQNIKIIFSKNNNTNQFFNVDLEIYNGFFNSKDKKKIQIIRNTDPVFLKHIFCNFHDSRLKNLFFRYRARNFFIH
What is the function of this protein?
Degrades single-stranded DNA (ssDNA) in a highly processive manner.  Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase.
What are the official names of this protein?
Exodeoxyribonuclease I, ExoI, Exonuclease I, DNA deoxyribophosphodiesterase, dRPase.
Protein: PLSY_CERS1
Sequence: MPAIESGLWALILTGVLGYLLGSIPFGIVITRALGLGDLRKIGSGNIGATNVLRTGNKPAALATLLLDSGKGAIAVLIARAAVGEDAAQLAAFTSFLGHLFPVWLGFRGGKGVATFLGTLLALAWPVGLACCLTWLATAALGRISSLSALVAAASGVLWMILLGYGQMAALGAVLAVLIFIRHHANIRRILAGTEPRIGKK
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARI4A_HUMAN
Sequence: MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPLRVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVSVVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR
What is the function of this protein?
DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity).  May function as part of an mSin3A repressor complex (PubMed:14581478).  Has no intrinsic transcriptional activity (By similarity).  Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity).  Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation.  Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity).  Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis.  May function as a leukemia suppressor (By similarity).
What are the official names of this protein?
AT-rich interactive domain-containing protein 4A, ARID domain-containing protein 4A, Retinoblastoma-binding protein 1, RBBP-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPF_XANC8
Sequence: MDITLTIFAQALAFAGLIWIVATKIWPPLLKAIEERQQKIAEGLAAADRSQKDLAQAQEKVNEALKDARTKANEIIDQAHARANQIIEAAKLEAIAEANRQKDLAQAEIDASATRAREELRRQVSSLAVSGAEKLLKREIDATAHKALLDELAAEI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RPOC_CROS8
Sequence: MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERSQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKSMDLEAECEQLREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDKINAKGEGMVLTGPKEAERLYRSGQAELHARVKVRITEYEKDANGEFVAKTSLIDTTVGRAILWMIVPKGLPFSIVNQPLGKKAISKMLNTCYRILGLKPTVIFADQTMYTGFAYAARSGASVGIDDMVIPAKKAEIIAEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKAMMDNLQTETVINRNGEEEQQVSFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTLEGITMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADILVARNTLLNEQWCDILEANSVDSVKVRSVVTCDTDFGVCAHCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSIRLSNAKSVVNSSGKLVVTSRNTELKLIDEFGRTKESYKVPYGAVMAKGDGEQVAGGETVANWDPHTMPVITEVAGYIRFTDMIDGQTITRQTDELTGLSSLVVLDSAERTAGGKDLRPALKIVDANGNDVLIPGTDMPAQYFLPGKAIVQLEDGVQISSGDTLARIPQESGGTKDITGGLPRVADLFEARRPKEPAILAEVAGIVSFGKETKGKRRLVITPVDGGDAYEEMIPKWRQLNVFEGERVERGDVISDGPEAPHDILRLRGVQAVTRYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKATIMDAGSSEFLEGEQVEYSRVKIANRELEANGKVSATYMRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAAGELPAAPQVTAEDASASLAELLNAGLGGNDNE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: DABB1_HALNC
Sequence: MMNLQWLIPLLPLLSALLVQLFAARLGKRVAHLSVALGTLTVIVAAYQLVAYIGTDASPSWHSLGTMWGSLYVDPLSSIMSLVVAGISLIVHVYSIRYMTEEPGYPRFFLLLDLMTASILLMVAAGDLVTLLIAWHMIGIMLYFLLGQNTESWPSQRYAFWTFITYRLGDLPLVLAAVLLYQTYGAIDFPTLFSRIAADPNATIMGLPTAITAAFLVALSAFAKSAQFPLHTWLPYTMEGPTPVSALMHAGIVNAGGFIINRFAPVFVHSDGVLHMLFVVGLITALVGSVLMLTQNDIKKSLGYSTMGQMGFMVMECGLGAFSLAVFHLIAHGLFKGTMFLGSGSMIHEARKHDGVPHNPLHTFLVERKSASLKLPWLFIGLATLVVPLFILVIAHWFVAPDFFEKQGAIVLLFFGWITGVQVLFATHHLDANNPIRMMMMILLSFTLIVVGYTFIGHAFENFLYPEEAFRNALYHAAGIDKLTFDGLVFLLALIVVAGWFSSYLASREKSVFGDRFGAVRLTLYSLISREFYVADLYDRMAHWLLDASKRFNVWMRWY
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabB1.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLPB_SALSV
Sequence: MKFDTVIMGGGLAGLLCGLQLQQHGLRCAIVTRGQSALHFSSGSLDLLSALPDGQPVTDITAGLDALRRQAPEHPYSRLGAQKVLTLAQQAQTLLNASGAQLYGDVQQAHQRVTPLGTLRSTWLSSPEVPVWPLSAQRICVVGVSGLLDFQAHLAAASLRQRDLNVETAEIDLPELDVLRDNPTEFRAVNIARLLDNEEKWPLLYDALSPIATNCDMIIMPACFGLANDTLWRWLNERLPCALTLLPTLPPSVLGIRLHNQLQRQFVRQGGIWMPGDEVKKVTCRRGTVSEIWTRNHADIPLRPRFAVLASGSFFSSGLVAEREGIREPILGLDVQQTATRAEWYQQHFFDPQPWQQFGVVTDDAFRPSLAGNTVENLYAIGSVLAGFDPIAEGCGGGVCAVSALQAAHHIAERAGEQQ
What is the function of this protein?
Conversion of glycerol 3-phosphate to dihydroxyacetone.  Uses fumarate or nitrate as electron acceptor.
What are the official names of this protein?
Anaerobic glycerol-3-phosphate dehydrogenase subunit B, Anaerobic G-3-P dehydrogenase subunit B, Anaerobic G3Pdhase B.
What is the protein family that this protein belongs to?
Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
Protein: LEUK_HUMAN
Sequence: MATLLLLLGVLVVSPDALGSTTAVQTPTSGEPLVSTSEPLSSKMYTTSITSDPKADSTGDQTSALPPSTSINEGSPLWTSIGASTGSPLPEPTTYQEVSIKMSSVPQETPHATSHPAVPITANSLGSHTVTGGTITTNSPETSSRTSGAPVTTAASSLETSRGTSGPPLTMATVSLETSKGTSGPPVTMATDSLETSTGTTGPPVTMTTGSLEPSSGASGPQVSSVKLSTMMSPTTSTNASTVPFRNPDENSRGMLPVAVLVALLAVIVLVALLLLWRRRQKRRTGALVLSRGGKRNGVVDAWAGPAQVPEEGAVTVTVGGSGGDKGSGFPDGEGSSRRPTLTTFFGRRKSRQGSLAMEELKSGSGPSLKGEEEPLVASEDGAVDAPAPDEPEGGDGAAP
What is the function of this protein?
Protects cells from apoptotic signals, promoting cell survival.
What are the official names of this protein?
Leukosialin, GPL115, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cell projection, microvillus. Cell projection, uropodium. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). SUBCELLULAR LOCATION: [CD43 cytoplasmic tail]: Nucleus. Nucleus, PML body. Note=The sumoylated form localizes to the PML body.
Protein: MSBA_BORBR
Sequence: MLAWRPGRPDGCRAAGGRRYNPGHDCIKASVSLNSAARNAPAGSQPVKAELWKRVYSRVGSYWKGLVLAVLLMAGAAATQPTLAVIMKPLLDDGFSGAKPHYVWFLPLAVVGLILLRGICNFFSDYLLAWVANNVLRGIRGEMFERLLGLPDADFKRGDTGRLLNRFTIDAGNVTGYATDVITVLVRETLVVIALIGVLLYMSWALTLIILVMLPVSVGIARAFTRRLRRINRETVNMNAELTRVVSEGIDGQRVIKLFDGYDAERRRFDFVNSRLRRFAMRSATADAALTPLTQVCISVAVGAVIAVALSQANSGALTVGSFASFMAALAQIFDPIKRLTNLAGKMQKMLVAAESVFTLVDQTPEADAGTRALPEPVRGKVEFRAVSHRFPDADRDTVSAVSFLVEPGQTVALVGRSGSGKTTLVNMLPRFVLPDGGDILFDDVPIQDLTLRSLRSHLSLVSQDVVLFDDTIAANVGYGAGGTVDDARVRDALAAANLLEFVDGLPLGIHTPVGQNAARLSGGQRQRLAIARALIKNAPVLILDEATSALDNESERQVQASLERLMRGRTTLVIAHRLSTVQNADRIIVLDAGKIVEHGPHSELLAANGLYASLYNMQFRED
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TVA83_HUMAN
Sequence: MLLELIPLLGIHFVLRTARAQSVTQPDIHITVSEGASLELRCNYSYGATPYLFWYVQSPGQGLQLLLKYFSGDTLVQGIKGFEAEFKRSQSSFNLRKPSVHWSDAAEYFCAVG
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 8-3.
What are the subcellular locations of this protein?
Cell membrane.
Protein: CYB6_SYNR3
Sequence: MANSSPVYDWFNERLEIQDIVDDISSKYVPPHVNIFYCLGGITLVCFLIQFATGFAMTFYYKPTVVEAYSSVQYLMTDVSFGWLIRSVHRWSASMMVLMLILHVFRVYLTGGFKRPRELTWVTGVTMAVITVSFGVTGYSLPWDQVGYWAVKIVSGVPAAVPVVGDFMVELLRGGESVGQSTLTRFYSLHTFVLPWLLAVFMLAHFLMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: KAD2_ASPOR
Sequence: MAPITEEAVSGLKDIIGKLEARVEELESRLSNGFKPKSVAEHMRMVLMGPPGAGKGTQAPALKDKYCVCHLATGDMLRSQVAKKTELGKEAKKIMDQGGLVSDEIMVNMIKSELDNNSECKNGFILDGFPRTVAQAERLDDMLAARQQKLQHAVELQIDDALLVARITGRLVHPASGRSYHKVFNPPKQEMKDDITGEPLIQRSDDNAETLKKRLGTYHAQTAPVVDYYKKTGIWRGIDASQEPGQVWKSLLGVFQQN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: 2A5G_MOUSE
Sequence: MLTCNKAGSGMVVDAASSNGPFQPVALLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEAVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYAVYSQASAVSIPVAMETDGPQFEDVQMLKKTVSDEARQAQKELKKDRPLVRRKSELPQDPHTEKALEAHCRASELLSQDGR
What is the function of this protein?
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.  The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation.  PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, PP2A B subunit isoform B'-alpha-3, PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B56 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere.
Protein: RL19_BURM1
Sequence: MNLIAKLEQEEIERALAGKTIPEFAPGDTVIVNVNVVEGNRKRVQAYEGVVIAKRNRGLNSSFIVRKISSGEGVERTFQTYSPLLASIVVKRRGDVRRAKLYYLRERSGKSARIKEKLVSKDRAAAASQE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: SYH_WOLWR
Sequence: MTNQTVRGTKDFLFDEWYKFKHIEQTASRISNLYGFLPAQTPIFEYTEVFTKTLGDSSDIITKEMYSFNDKGGKSITLRPEFTAAIVRLLIEKKLQTPIKLFSTGPAFRYERPQKGRQRQFHQINFEVFGIEDPKADIELISLVQHLLTEFGINKNVKLEINSLGDGETITKYREALILYFTKYQNDLSEDSKNRLIKNPLRILDSKDEKDKSIISDAPKISNYYTKGSSDFFEQILNGLTILDIPYTVNNKLVRGLDYYCHTVFEFVTEDLGAQGAVFAGGRYDNLVSSVGGKHTPAIGFAGGIERIMELINYSPKEERPIYLIPIGREAEKHALTLANELRRNGLYVIYEYSGTLRTRMKKANQANAKAALIFGDEELSSKTLKIKNMNTGEEKIIARDNTIENIY
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD7_MACFA
Sequence: INAEKMVLKFGRKTRKFATYVVAAGLQYGAEGGMLHTFFKMAWLGEIPALPVFGDGTNVIPTIHVLDLAGVIQNVIDHTPKPHYLVAVDESVHTLEDIVKCISKNTGPGKIQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWVAQTGFVENINSILKEYKQSRGLMPVKICILGPPAVGKSSIAEELAKYYKLHHIQLKDVISEAIAKLETIVAPKDIGEGKEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDEVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPERIVAGTHYSQDRFLRALSNYRDINIEDETVFNYFDEIEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECCNVRPEDPVDFLAEYLFKNNPEAQ
What is the function of this protein?
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.  Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP.  Also displays broad nucleoside diphosphate kinase activity.  Involved in maintaining ciliary structure and function.
What are the official names of this protein?
Adenylate kinase 7, AK 7, ATP-AMP transphosphorylase 7.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the dpy-30 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell projection, cilium, flagellum. Note=Detected along the full length of sperm flagellum, where it colocalizes with alpha-tubulin.
Protein: ATG5_BEAB2
Sequence: MSAPISQALWDARIPLLITHPLAPTTPFITSIPRFSYLALLLPRLSAFFNTPCSSFHFEDVVLRNLPVGLLVDLYQPSLPWRLIVNDGVSWDISDTFLNAAKEADFIRNGNANQIMKLSKDDTRQLWHAVIDNDLAAFSRINNRLLNAPTALKHVPMRIYLPLAPGGSAGGDVGEPTVDQQQGGGDASAAGAFKIIQSLVQPLGADRRPRLLGQVLRETMPKLFPSSRDPVMANVLLHGVAVPFNAPLADLMREAAYFDGWLSFVVVVL
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation (By similarity).  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation (By similarity).  Required for selective autophagic degradation of the nucleus (nucleophagy) (By similarity).  Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production (By similarity).  Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function (By similarity).  The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).  ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity (By similarity).  Required for proper vegetative growth, asexual/sexual reproduction, but, unlike several plant and animal pathogenic fungi, where ATG5 is required for infection, in B. bassiana it is dispensable for pathogenesis (PubMed:23197175).
What are the official names of this protein?
Autophagy-related protein 5.
What is the protein family that this protein belongs to?
Belongs to the ATG5 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Localizes to the isolation membrane (IM), a membrane sac which is generated from the pre- autophagosomal structure (PAS) (By similarity). Ultimately, the IM expands to become a mature autophagosome (By similarity). Localizes also to a dot at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS) (By similarity). Correct localization to the PAS requires ATG21 (By similarity).
Protein: UBIG_PHOLL
Sequence: MNIKTPSTPNNVDQQEIEKFEAIASRWWDLEGEFQPLHRINPLRLNYILQRSGGIFGKKVLDVGCGGGILSESMAREGADVTGLDMGTEPLQVARLHALETGIPVTYVQETVESHAEKYPQAYDIVTCMEMLEHVPDPQSVVHACAQLVKPGGHVFFSTINRNKKAWLMAVIGAEYILKMVPKGTHDAKKFIRPSELIGWIDRTSLREKHIIGLHYNPLTDKFSLGHNVDVNYMLHSQYV
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.