PharMolix/UniProtQA huggingface dataset:
Protein: PUCL_BACSB
Sequence: MMRLKQLNEMSASEFIHLLGGVFENSSWVAERAEPNRPYSSFQSLYNKMVEIVETASDNEQLKLIQMHPHLGTNVKITDFSQEEQKHAGLNELTKDEQNHLILLNQKYKDKFGFPFVMAVRGKIKQEIFRTIKERLQNNHQTEFKQALEEIKKIAMFRLQEIFREGENNSMTKHKERVMYYGKGDVFAYRTYLKPLTGVRTIPESPFSGRDHILFGVNVKISVGGTKLLTSFTKGDNSLVVATDSMKNFIQKHLASYTGTTIEGFLEYVATSFLKKYSHIEKISLIGEEIPFETTFAVKNGNRAASELVFKKSRNEYATAYLNMVRNEDNTLNITEQQSGLAGLQLIKVSGNSFVGFIRDEYTTLPEDSNRPLFVYLNIKWKYKNTEDSFGTNPENYVAAEQIRDIATSVFHETETLSIQHLIYLIGRRILERFPQLQEVYFESQNHTWDKIVEEIPESEGKVYTEPRPPYGFQCFTVTQEDLPHENILMFSDEPDHKGALK
What is the function of this protein?
Catalyzes two steps in the degradation of uric acid, i. e.  the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin (By similarity).
What are the official names of this protein?
Uric acid degradation bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the uricase family.
Protein: WDR5A_ARATH
Sequence: MAEEIPATASFTPYVHSQTLTSHNRAVSSVKFSSDGRLLASASADKTIRTYTINTINDPIAEPVQEFTGHENGISDVAFSSDARFIVSASDDKTLKLWDVETGSLIKTLIGHTNYAFCVNFNPQSNMIVSGSFDETVRIWDVTTGKCLKVLPAHSDPVTAVDFNRDGSLIVSSSYDGLCRIWDSGTGHCVKTLIDDENPPVSFVRFSPNGKFILVGTLDNTLRLWNISSAKFLKTYTGHVNAQYCISSAFSVTNGKRIVSGSEDNCVHMWELNSKKLLQKLEGHTETVMNVACHPTENLIASGSLDKTVRIWTQKKE
What is the function of this protein?
Forms multiple COMPASS-like complexes involved in histone methylation by interacting with different histone H3 'Lys-4' methyltransferases such as ATX1, SDG14 or SDG16 (PubMed:21423667).  Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed:19567704).  Up-regulates FLC and MAF4 expression to delay flowering (PubMed:19567704).  Present at the promoters and at the transcription start sites (TSS) regions of WRKY70 and LTP7; this occupancy is ATX1-dependent (PubMed:23284292).  Involved in the transition from transcription initiation to transcription elongation (PubMed:23284292).
What are the official names of this protein?
COMPASS-like H3K4 histone methylase component WDR5A, AtWDR5A.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOB_POLSJ
Sequence: MAYSYTERKRIRKSFGNRESVLTVPYLLQMQKDAYTAFLQADRAPQKRTVEGLQAAFENAFPIVSHNGFVEMKFIEYNLAKPAFDVRECQTRGLTFASAVRAKVQLIIYDRESSTSQSKVVKEVKEQEVYMGEVPLMTDKGSFVINGTERVIVSQLHRSPGVFFEHDKGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDVLYFRVDRRRKMPVTILLKAIGLNPESILANFFVFDHFRLMDSGAQMEFVAERMRGEVARFDITDKSGKVVVAKDKRITVRHTRELEQSGTTTISVPEDFLVGRVVAKNIVDAETGEIIAKANDELTELLLKKLRLAGVQDLQVLYTNELDQGAYISQTLRADETADEFAARVAIYRMMRPGEPPTEDAVQALFQRLFYNPDTYDLSKVGRMKFNARVGRDDSTGPMVMTNEDILAVVKILVDLRNGNGEVDDIDHLGNRRVRCVGELAENQYRTGLARIEKAVKERLGQAEQEPLMPHDLINSKPISAALKEFFGASQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHVTHYGRVCPIETPEGPNIGLINSLALYARLNEYGFIETPYRRVVDSKITDQIDYLSAIEEGKYVIAQANALLDDSGTLTGDLVSARENGESVLVGAERIQYMDVSPAQIVSVAASLVPFLEHDDANRALMGANMQRQAVPVLRPEKAFVGTGIERVSAVDSGTVVTANRGGVVDYVDATRIVVRVNDAEALAGEVGVDIYNLIKYQRSNQNTNIHQRPIVKIGDKLAKGDVIADGASTDIGELALGQNMLVAFMPWNGYNFEDSILISERVVAEDRYTSIHIEELVVMARDTKLGSEEITRDIPNLSEQQLNRLDESGIIYVGAEVQPGDTLVGKVTPKGETTLTPEEKLLRAIFGEKASDVKDTSLRVSQGSQGTVIDVQVFTREGIVRDKRAQQIIDDELKRFRLDLNDQLRIVEADAFDRIEKLLNGKVANGGPKKLAKGTKIDKAYLADVEKYHWFDIRPADDEVASQLESIKNAMEQTRHSFDLAFEEKRKKLTQGDELPAGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPVEDMPYMADGTPCDIVLNPLGVPSRMNVGQVLEVHLGWAAKGLGQRIGDMLQAEAKVAELRKFMDTLYNKSGRVEDLANLSDTDVLEMARNLTTGVPFATPVFDGASEEDIMTMLKLAYPDDIAKAKGLTATRTQAQLYDGRTGDQFERTTTVGYMHVLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYTLQEMLTVKSDDVQGRTKVYESIVKGEHAITAGMPESFNVLVKEIRSLGIDIELERS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: G6P_BPPF3
Sequence: MARLLALVIGYALSSFVLKLFTVLGVGIFTYVGLTALVDGFLNLLQPMLTGLPSYILDILAIAGVPEALSIVGSALLTRASINSAKAFVGVLT
What is the function of this protein?
Plays essential roles both in the entry of the viral genome into the bacterial host and in budding process.  The formation of the G3P-G6P complex termed adsorption complex is essential for correct termination of filamentous phage assembly (By similarity).
What are the official names of this protein?
Head virion protein G6P, Coat protein D, G6P.
What is the protein family that this protein belongs to?
Belongs to the inovirus G6P protein family.
What are the subcellular locations of this protein?
Virion. Host membrane; Multi-pass membrane protein. Note=Prior to assembly, G6P is found associated with the bacterial host inner membrane. There are about five copies of G6P in the mature virion. They are located together with G3P at the head side of the filamentous virion (By similarity).
Protein: RL25_HALHL
Sequence: MTVEMRLDAHPRTETGRGAMRRLRRARRVPGVVYGAGKEPQPVALENDQLYRLLEEEAFFSTILKVQMGSETEQAIVKDLQRHPFKPLVQHIDLQRVREDQPITVHVPLHVHGEEQSPGVKKGGVLHHDLLDLEVVCLPKDLPPFIDVDVSSLKVGQAVHISELTLPEGVQSAALQQGEEYDAPVVSVQATRKTRGASSDDEAESSESE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: METAA_BACC3
Sequence: MPIIIDKDLPARKVLQEENIFVMTKERAETQDIRALKIAILNLMPTKQETEAQLLRLIGNTPLQLDVHLLHMESHLSRNVAQEHLTSFYKTFRDIENEKFDGLIITGAPVETLSFEEVDYWEELKRIMEYSKTNVTSTLHICWGAQAGLYHHYGVPKYPLKEKMFGVFEHEVREQHVKLLQGFDELFFAPHSRHTEVRENDIRGVKELTLLANSEEAGVHLVIGPEGRQVFALGHSEYSCDTLKQEYERDRQKGLNIDVPKNYFKHNNPNEKPLVRWRSHGNLLFSNWLNYYVYQETPYVL
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_CLOPS
Sequence: MQDDLKNAPIGFFDSGLGGLSVLRKALEMMPNENYIYYGDSKHAPYGEKTPQEIRSLSFNAIEFLIKKGAKAIVIACNTATSAAAHDLREYYKDIPIIGIEPALKPAIKLHETGSVIVMATKATLTQEKFKNLMDKYGEHREVIPLPCPGLVEFIEAGNLEGEEVKNFLREKLNPYMDREISSIVLGCTHYPFVKDVIQDIVGEKVDIIDGSSGTIRELKRRLEENNMQSELKKKGDLDIFNSLEDNKILELSKKLIEIK
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: TRPD_BUCBP
Sequence: MKIILNKIYQGDTLNISETYTLFKSIMLKKINNIELSAILIALKIRGESQNEILGAVKACLEHMITFPKPTYMFSDIVGTGGDNSNSINISTTSALVGSACGFKIAKHCNGNISSKTGSADILKKFGINIQISPEKSKKMLDELNICFLFAPQYHINFKVVTQVRKILRIKTIFNIIAPLLNPAMPKLTVMGVCNFKLMLPIAQVLKTLNYHHAIIVCSDNIDEVTLHSFTKIIELKNNNITSYILHPDDFGVKYCHKNDILGGNTEENYNIIKKILQGKGPSAVTETIAVNVAILFKIFGYSNLKKNTEYALKVIRSGKVYEKIIQLSKF
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: TYSY_LACAC
Sequence: MAILEQPYLDLINKIMIEGHDKNDRTGTGTRSYFGAQMRFDLSKGFPILTTKKVPFGLIKSELLWFLRGDTNIRFLLEHKNHIWDEWAFKNWVNSDEYTGPDMTDFGLRSQSDPEFNKIYQAELKKFDRRILDDENFAKKYGNLGDVYGAQWRHWQKRDGSFIDQIENVIEQIKNNPDSRRMIVTAWNPEDVPTSALPPCHVMFQFYVVDGKISVQLYQRSGDMFLGVPFNIASYALLLNMIARETGLQVGEFIHTLGDAHIYSNHFSQVKEMLSRKPYESPQLWLNPEKKHIEDFDMQDIKLVDYKHHGTIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSHB_CHRVO
Sequence: MRILFIADPLEHFKIYKDTTFAMMEEAHRRGHAISFAEAHQLSVEGGRLQVDACDLAVTDERPDWYKLGPKLRQPLTAFSAVVMRKDPPFDMEYLYASQLFTLAEAQGVKVFTSGQALRDFNEKLAILHFPELISPTLISGEAHRLRAFVNQHQDVILKPLDSMGGDSIFRVKPDDPNLSVIIETITWRGKRTVMAQRYIPEIRDGDKRILVIDGVPVDHCLARIPAAGETRGNLAAGGRGEARPLSARDREIAETVGPELKKRGILLAGLDVIGNYLTEVNVTSPTCFREIMDQTGVNVAGLYIDALERRCQH
What are the official names of this protein?
Glutathione synthetase, GSH synthetase, GSH-S, GSHase, Glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic GSH synthase family.
Protein: HMCES_PONAB
Sequence: MCGRTSCHLPRDVLTRACAYQDRRGQQRLPEWRDPDKYCPSYNKSPQSNSPVLLSRLHFVKDADSSERIIAPMRWGLVPSWFKESDPSKLQFNTTNCRNDTIMEKRSFKVPLGKGRRCVVLADGFYEWQRCQGTNQRQPYFIYFPQIKTEKSGSIGAADSPENWGKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGEEAVSKWLDFGKVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVRKELKASGSSQRMLQWLATKSPKKEDSKTPQKEESDVPQWSSQFLQKSPLPTKRGTAGLLEQWLKREKEEEPVAKRPYSQ
What is the function of this protein?
Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites.  Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue.  The HMCES DNA-protein cross-link is then degraded by the proteasome.  Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks.  Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (By similarity).  Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway.  Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).
What are the official names of this protein?
Abasic site processing protein HMCES, Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, Peptidase HMCES, SRAP domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SOS response-associated peptidase family.
What are the subcellular locations of this protein?
Chromosome. Note=Recruited to chromatin following DNA damage. Localizes to replication forks.
Protein: FUCM_SHIB3
Sequence: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
What is the function of this protein?
Involved in the anomeric conversion of L-fucose.
What are the official names of this protein?
L-fucose mutarotase, Fucose 1-epimerase, Type-2 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. FucU mutarotase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSS51_RAT
Sequence: MAPRSRRRKHKKPPPVTPMPDIPPTDVSAVRPALPEPGPSIDALGFIALDSDVPGLPQRILQRLNMKSYEEYKLVIDGGTPVPSFGFRCQQEMFQRMEDTFRFCAYCKALPHGLSSCKVLRHCKRCRNVYYCDAECQRSDWPAHRKVCGELRLVAVDRVMEWLLVTGDFVLPSGPWPWLPEEIQNWDTWFSMRGLQLESTLNALLGSHAMTMLWASLGRPRPDPDVLHGSLKRLMTDVLSRPLTLGLGIRTLAIDVGKTGGSTLHVVGASHVETFLIRSGDYDELGYMFPENLGFRVIMVGVDVSADLLQSSSSLPLEPGTVQLSGHRALYHDFWEEQIETGNLAHPDLVAAFHPGFHASPGLMEAWLPTLLLLRDYEIPTLITVYSQQELEASLQVLVNLDTHIIACGANPFASLKPEQVYSKPNKQPVYSSAYYIVFRGCSSCQLDKQQVEEEPDEFSVVESNPN
What are the official names of this protein?
Putative protein MSS51 homolog, mitochondrial, Zinc finger MYND domain-containing protein 17.
Protein: 1A14_ARATH
Sequence: MVQLSRKATCNSHGQVSSYFLGWEEYEKNPYDVTKNPQGIIQMGLAENQLCFDLLESWLAQNTDAACFKRDGQSVFRELALFQDYHGLSSFKNAFADFMSENRGNRVSFDSNNLVLTAGATSANETLMFCLADPGDAFLLPTPYYPGFDRDLKWRTGVEIVPIQSSSTNGFRITKLALEEAYEQAKKLDLNVKGILITNPSNPLGTTTTQTELNILFDFITKNKNIHLVSDEIYSGTVFNSSEFISVMEILKNNQLENTDVLNRVHIVCSLSKDLGLPGFRVGAIYSNDKDVISAATKMSSFGLVSSQTQYLLSSLLSDKKFTKNYLRENQKRLKNRQRKLVLGLEAIGIKCLKSNAGLFCWVDMRPLLRSKTFEAEMDLWKKIVYEVKLNISPGSSCHCEEPGWFRVCFANMIDETLKLALKRLKMLVDDENSSRRCQKSKSERLNGSRKKTMSNVSNWVFRLSFHDREAEER
What is the function of this protein?
1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate synthase 4, ACC synthase 4, S-adenosyl-L-methionine methylthioadenosine-lyase 4.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: UL31_HCMVA
Sequence: MGDKPTLVTLLTVAVSSPPPSSPLPLVSFTELLLPPPSVAAAAVAATATSEVGEKTAEQEVAAADPETGNERRENRENEGGETRTTGTTAVKRSHDGIPRQLAERLRLCRHMDPEQDYRLPAQDVVTSWIEALRDADRDNYGRCVRHAKIHRSASHLTAYESYLVSITEQYNTASNVTEKASYVQGCIFLSFPVIYNNTQGCGYKYDWSNVVTPKAAYAELFFLLCSTSESSVVLQPLITKGGLCSSMAVYDEETMRQSQAVQIGFLHTQLVMVPFVPHACPHYAVPFTTPGKPGCGGAPSGVAGLEEAAPFGRVSVTRHGATLLCRVDHLTWISKRVTTYGHKKITRYLAQFRGTMDDDEAALPGEDEAWIASKNVQYEFMGLIFTVNVDSLCVDAEQRQLLGTVATSFCHRVSDKITARNMPRAFSFYLLTSAQRGYDLRFSRNPSLFFSGDALNCPLLNEPNVFSLTVHAPYDIHFGVQPRQTVELDLRYVQITDRCFLVANLPHEDAFYTGLSVWRGGEPLKVTLWTRTRSIVIPQGTPIATLYQITEGDGNVYSYNHHTVFRQMHAAGTTTFFLGDMQLPADNFLTSPHP
What is the function of this protein?
Plays a role in the inhibition of host innate immune system by targeting host CGAS and promoting dissociation of DNA from CGAS, thereby inhibiting the enzymatic activity of CGAS.
What are the official names of this protein?
Protein UL31.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae U10 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: RL22_SYNS9
Sequence: MTSSTSTAATAQAHGRFIRGSVSKVRRVLDQIRGRTYRDALIMLEFMPYRSTGPITKVLRSAVANAENNLGLDPASLVISSASADMGPSMKRYRPRAQGRAFQIKKQTCHISIAVAVQTDS
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: SYS_PASMU
Sequence: MIDPNLLRNNLEEVAEKLKVKRNFVLDVALLSELEEQRKSLQVKTESLQAERNARSKNIGQAKARGEDISALLNEVEHMGIELSTTKAHLDEVLAEINQIVLAIPNLPADEVPLGKDESENLEVFRWGTPKTFDFDVKDHVSLGEGLKGLDFAAGVKLSGSRFVVMKGQIAKLHRALSQFMLDLHTEQHGYTETYVPYLVNHATLYGTGQLPKFGEDLFHTNALEGEQPYALIPTAEVPVTNLVRDEILDEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQIVAPETSMQVLEELTGQAEKVLQLLELPYRKVLLCTGDMGFGSCKTYDLEVWLPAQNTYREISSCSNMWDFQARRMQARCRSKTDKKTRLVHTLNGSGLAVGRTLVAILENYQNADGTITVPSVLRPYMGGLAQIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BBS5_MOUSE
Sequence: MSVLDVLWEDRDVRFDVSSQQMKTRPGEVLIDCLDSIEDTKGNNGDRGRLLVTNLRIIWHSLALPRVNLSIGYNCILNITTRTANSKLRGQTEALYILTKCNTTRFEFIFTNLVPGSPRLFTSVIAVHRAYETSKMYRDFKLRSAVIQNKQLRLLPQEHVYDKINGVWNLSSDQGNLGTFFITNVRIVWHANMNDSFNVSIPYLQIRSIKIRDSKFGLALVIESSQQSGGYVLGFKIDPVEKLQESVKEINSLHKVYSASPIFGVNYEMEEKPQPLEALTVEQIQDDVEIDSDDHTDAFVAYFADGNKQQDREPVFSEELGLAIEKLKDGFTLQGLWEVMS
What is the function of this protein?
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).
What are the official names of this protein?
Bardet-Biedl syndrome 5 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the BBS5 family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to basal bodies.
Protein: PURQ_PROM9
Sequence: MDNFTVGVVVFPGSNCDRDVSWALEGCLDIRTKYLWHESSDLSDVDAIVLPGGFSYGDYLRCGAIARFSPLINALDEFVKSGKRVLGICNGFQILTESGFLPGALVANKNLNFICDDVELDIVSTKGGWFNNGDEKQTIKLPIAHGEGRYHCDSDTLKKLVDNELIALRYKNNPNGSSFDIAGITNEKGNVLGLMPHPERACDETIGGTDGLFTLKSLILK
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_BURMS
Sequence: MSIKSDKWIRRMAEEHKMIEPFVPDQVRAAEDGRKIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEGSFVDFKGDVCIIPPNSFALARTVEYFRIPRTVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVLFFESDEVCDVSYADRGGKYQGQRGVTLPKT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: HEM6_CAUSK
Sequence: MTDTSDLDGKKATARAWFESLRDQICAEFERLEDEAPTDLYAGEPGRFVRKPWDREAGGGGVMSMMHGRLFEKVGVHVSTVFGTFTPEMAKNMPGADEDPRFFATGISLIAHMRSPRVPAVHMNTRFIATTKSWFGGGGDLTPLLGYQRQQDFPDAIDFHAAYQRACDAHDPTWHAKYKAWCDEYFFLPHRNEPRGIGGIFYDHHDSGDWAKDFAFTQDVGRAFLEIYPTLVRRRMGETWSAEEREQQLVQRGRYVEFNLLYDRGTMFGLKTGGNVESILSSMPPEVKWP
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_NITHX
Sequence: MDIRAAEISAILKDQIKNFGQEAEVSEVGQVLSVGDGIARVYGLDNIQAGEMVEFENGTRGMALNLETDNVGIVIFGADREIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGPIQATERKRVDVKAPGIIPRKSVNEPMATGLKSIDALIPVGRGQRELIIGDRQTGKTAIALDTILNQKPLNVAGAPEGQKLYCVYVAIGQKRSTVAQFVKVLEEQGALEYSIIVAATASDPAPMQYIAPFTGCTMGEYFRDNGMHAVIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDHGNGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFFQGIRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYREMAAFAQFGSDLDASTQRLLNRGSRLTELLKQPQFSPLKMEEQVCVIWAGTNGYLDKLPLGKVRAFEDGLLSLLRGKNVEILNTIRESRDLSDDTAAKLRSAVDGYAKTFV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: H3A02_CYRHA
Sequence: MKASMYLALAGLVLLFVVGYASESEEKEFPRELLSKIFAVDDFKGEERGCKGFGDSCTPGKNECCPNYACSSKHKWCKVYLGK
What is the function of this protein?
Selective antagonist of neuronal tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (IC(50)=1270 nM on Nav1. 1/SCN1A, 270 nM on Nav1. 2/SCN2A, 491 nM on Nav1. 3/SCN3A and 232 nM on Nav1. 7/SCN9A).  This toxin suppress Nav1. 7 current amplitude without significantly altering the activation, inactivation, and repriming kinetics.  Short extreme depolarizations partially activate the toxin-bound channel, indicating voltage-dependent inhibition of this toxin.  This toxin increases the deactivation of the Nav1. 7 current after extreme depolarizations.  The toxin-Nav1. 7 complex is gradually dissociated upon prolonged strong depolarizations in a voltage-dependent manner, and the unbound toxin rebinds to Nav1. 7 after a long repolarization.  Moreover, analysis of chimeric channels showed that the DIIS3-S4 linker is critical for toxin binding to Nav1. 7.  These data are consistent with this toxin interacting with Nav1. 7 site 4 and trapping the domain II voltage sensor in the closed state.
What are the official names of this protein?
Hainantoxin-III 2, HnTx-III, Hainantoxin-3.2, Mu-theraphotoxin-Hhn2a, Mu-TRTX-Hhn2a, Peptide F7-18.76.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 15 (Hntx-3) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARSC_BACCQ
Sequence: MENKKTIYFLCTGNSCRSQMAEAWGKQYLGDKWNVYSAGIEAHGVNPNAIKAMNEVNIDITNQTSDIIDANILNRADLVVTLCSHADAVCPSTPPDVHRVHWGFDDPAGKEWSEFQRVRDEIGERIKRFSETGE
What is the function of this protein?
Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].
What are the official names of this protein?
Arsenate reductase.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.