PharMolix/UniProtQA huggingface dataset:
Protein: DDIT3_CRIGR
Sequence: MAAESLPFTLETVSSWELEAWYEDLQEVLSSDENGGPYSSSLGNEEGESKTFTTLDPASLAWLTEEPGPAEVTSSSQSPRSPDSSQSCMAQEEEEDQGRTRKRKQSGQCPARGTGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRPGSDRPHVNLQQV
What is the function of this protein?
Multifunctional transcription factor in ER stress response.  Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress.  Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes.  Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes.  Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.  Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG).  Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity.  Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (By similarity).
What are the official names of this protein?
DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein, CHOP, C/EBP-homologous protein 10, CHOP-10, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA-damage-inducible protein GADD153.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.
Protein: Y704_STAAN
Sequence: MKIAVMTDSTSYLSQDLIDKYNIQIAPLSVTFDDGKNFTESNEIAIEEFYNKMASSQTIPTTSQPAIGEWITKYEMLRDQGYTDIIVICLSSGISGSYQSSYQAGEMVEGVNVHAFDSKLAAMIEGCYVLRAIEMVEEGYEPQQIIDDLTNMREHTGAYLIVDDLKNLQKSGRITGAQAWVGTLLKMKPVLKFEDGKIIPEEKVRTKKRAIQTLEKKVLDIVKDFEEVTLFVINGDHFEDGQALYKKLQEDCPSGYQVAYSEFGPVVAAHLGSGGLGLGYVGRKIRLT
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein SA0704.
Protein: SFSA_BRUA4
Sequence: MIFQTPLVTGRLERRYKRFLADVTLDDGRFITASVPNTGSMLGLTAPGSRVWLSVSDAPHRKYAHTLQIVEADNTLVGVNTGLPNRIAEEAILNSLIPDLAGYASLKREQKYGRNSRIDLLLDDGPRQRAYVEVKNVHFIRTLGLAEFPDTVTARGAKHLDELVDVVAAGHRGVMLFIIQRNDCSRFSISGDLDPTYARAFERARANGVEAWAVRCHITDKSIDASELVPIE
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: RL5_BACLD
Sequence: MNRLKEKYNKEITPALMKKFEYKSVMQVPKIEKIVINMGVGDAVQNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDKLISVSLPRVRDFRGISKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTANTDEEARELLTQLGMPFQK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RL4_CHLMU
Sequence: MVLLSKFDFSGKESGKVELPDAFFAEGKEQSVKDYLVAIQANKRQWSACTRGRSEVSHSTRKPFRQKGTGNARQGCLAAPQFRGGGIVFGPKPKFDQHVRINKKERRAAIRLLLAQKIQTGKLIVADNSVFISSLNAPKTKEALRFLKECNVECRGVLFVDGLDHVGSNENLRLSVRNLAAVRGFTYGENINGYDIAAARNIVVSEKALELLVENLVSTTKD
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: LT_POVJC
Sequence: MDKVLNREESMELMDLLGLDRSAWGNIPVMRKAYLKKCKELHPDKGGDEDKMKRMNFLYKKMEQGVKVAHQPDFGTWNSSEVPTYGTDEWESWWNTFNEKWDEDLFCHEEMFASDDENTGSQHSTPPKKKKKVEDPKDFPVDLHAFLSQAVFSNRTVASFAVYTTKEKAQILYKKLMEKYSVTFISRHGFGGHNILFFLTPHRHRVSAINNYCQKLCTFSFLICKGVNKEYLFYSALCRQPYAVVEESIQGGLKEHDFNPEEPEETKQVSWKLVTQYALETKCEDVFLLMGMYLDFQENPQQCKKCEKKDQPNHFNHHEKHYYNAQIFADSKNQKSICQQAVDTVAAKQRVDSIHMTREEMLVERFNFLLDKMDLIFGAHGNAVLEQYMAGVAWIHCLLPQMDTVIYDFLKCIVLNIPKKRYWLFKGPIDSGKTTLAAALLDLCGGKSLNVNMPLERLNFELGVGIDQFMVVFEDVKGTGAESRDLPSGHGISNLDCLRDYLDGSVKVNLERKHQNKRTQVFPPGIVTMNEYSVPRTLQARFVRQIDFRPKAYLRKSLSCSEYLLEKRILQSGMTLLLLLIWFRPVADFAAAIHERIVQWKERLDLEISMYTFSTMKANVGMGRPILDFPREEDSEAEDSGHGSSTESQSQCFSQVSEASGADTQENCTFHICKGFQCFKKPKTPPPK
What is the function of this protein?
Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation.  Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA.  Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA.  Participates in the modulation of cellular gene expression preceeding viral DNA replication.  This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53.  Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.  Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression.  Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters.  Initiates viral DNA replication and unwinding via interactions with the viral origin of replication.  Binds two adjacent sites in the SV40 origin.  The replication fork movement is facilitated by Large T antigen helicase activity.  Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization.  Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription.
What are the official names of this protein?
Large T antigen, LT, LT-AG.
What are the subcellular locations of this protein?
Host nucleus.
Protein: YKV6_SCHPO
Sequence: MGENIEISTKVIENQEIRFRCYKADSTKIAVLAHPYAFLGGSVDDINIIALSKKINSKGFTVYVLDATTRRSALLSGKHDTMIFTLFVKYITSLNHPEYLLLGGYSYGARISMHKSITLAIDKRISHVSYLFLAPYLGLGSSILSWSWGLGFESFSTDSKVLFVWPDNDEFTREGTFETTLAKLKNRCPETTPLKLTDCSHMLSPSSRKILLETVDKWLASALNV
What are the official names of this protein?
Uncharacterized protein C959.06c.
Protein: RSMG_ORITB
Sequence: MLQQIYDFLNINYNVSRETFNKFKEYYSLLSKWNSTINLVSATTLQNFWQRHIFDSIQLLNYIHNKDIIVADLGSGAGFPGVVLSISGIKNVILIESDSRKAAFLLQAAQLSDQKIEIINDRIQNLKVKCDLVTVRALANLSTILSHTKQFTVKDKYLILKGKNYQHEITQALLHNKFNYTLYQSCTDDSSWILEIRI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSTB1_NITOC
Sequence: MSRQETTPYTLGEIEQGTPCCVPKALLRVRDLAVSYGEITVLSQVSLDIYKGCITALIGPSGCGKTSFLSTLNRLTDHHERARVNGRILFDGQDLLCDPVDTLRLRRRIGMIFQRPNPFPLSIWRNLELPLKEHGVRDRQTRYRKIEQALKDVGLWDEVSDRLGISALVLSGGQQQRLCIARALVLEPEILLMDEPCSALDPISSGVVEELILRLRGRYTVVIVTHNLAQARRVANYAGFFWMTERVGKLIEFGQCQHLFETPSHELTAAYISGARG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PURL_SULAC
Sequence: MRLSLSSQEMELVRKFLGREPKEEEWLVVDALWSEHCSYKSSKIFLRSFPSEGERVVMGIEDWQDAGALDVGDGWAVVLKLESHNHPSAIDPFNGAATGIGGIIRDIISKGARPIALLDMIRVGNLNNSRNRWLLKNIIAGIGFYGNSIGVPVVAGELAFDETYNDNPLVDVAGLGVVKKDKIVPSVVKEAGLKIVLVGLTGLDGLGGASFASRKLSGEDEIGAVQIADPFAGKIVLDVTLQIADKVEAIKDLGGGGLVVGITEMANGLGVEVELDKIPLRVKDLTPGEILVSETQERMVFAVKPERVKEVCEAFEYYEYPCAVIGEFTNDTSIRFLYKGKEVVNLPSSLLLNPPRYKWGVKKTKYSVYYEKPNINLEVAVKEILSYPDLVSKFWAYSQFDYEVGTSTVLKPGEADSGLISLPNGKLLAIKGDANPDLCAEDSYECGRYIVAEAYRNLATVGAKGIGVVDHLQFGDPKKPEVYYQFVEAVRGIAEASKYFGTPIVGGKVSFYNENKEGKPIKPTPLVVMAGLVQDKFLRPKITEGASIIMIGFTREEMGGSLLAKIFGNYGDVPKTRLNEELLSSELVIKAINDGKIIFAKDISKGGLVGALLPILVRGFGVSIDTNLIPSDTDDVISKLFSENGGRFIVLSEREDDINWLESQSRGIYVSKIGEVTREQYVMWLREGKKIDLTKEVNNYHRYLEEVTSD
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDKA2_HUMAN
Sequence: MSYKPIAPAPSSTPGSSTPGPGTPVPTGSVPSPSGSVPGAGAPFRPLFNDFGPPSMGYVQAMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART
What is the function of this protein?
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:33283408).  Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148).  Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (By similarity).  Regulates microtubule organization of metaphase II oocytes (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 2-associated protein 2, CDK2-associated protein 2, DOC-1-related protein, DOC-1R.
What is the protein family that this protein belongs to?
Belongs to the CDK2AP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules.
Protein: HS23C_OXYRB
Sequence: MASMALRRLASRNLVSGGIFRPLSVSRSFNTNAQMGRVDHDHELDDRSNRAPISRRGDFPASFFSDVFDPFRATRSVGQLMNLMDQLMENPFMAASRGSGRAMRRGWDVREDEEALELKVDMPGLAKEDVKVSVEDNTLIIKSEAEKETEEEEQRRRYSSRIELTPNLYKIDGIKAEMKNGVLKVTVPKIKEEEKKDVFQVMVD
What are the official names of this protein?
Small heat shock protein, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: POTA_ECOK1
Sequence: MGQSKKLNKQPNSLSPLVQLAGIRKCFDGKEVIPQLDLTINNGEFLTLLGPSGCGKTTVLRLIAGLETVDSGRIMLDNEDITHVPAENRYVNTVFQSYALFPHMTVFENVAFGLRMQKTPAAEITPRVMEALRMVQLETFAQRKPHQLSGGQQQRVAIARAVVNKPRLLLLDESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGRIEQDGTPREIYEEPKNLFVAGFIGEINMFNATVIERLDEQRVRANVEGRECNIYVNFAVEPGQKLHVLLRPEDLRVEEINDDNHAEGLIGYVRERNYKGMTLESVVELENGKMVMVSEFFNEDDPDFDHSLDQKMAINWVESWEVVLADEEHK
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PYRK_BACLD
Sequence: MRKGYMTVRSNKCIADHIYQMVLEGEIAEVCGAPGQFLHIKVSDSLTPLLRRPISIADINKAARQVTIIFRKDGEGTRLLSLKQEGDQLDVLGPLGNGFPAESLEQGKTALLVGGGIGVPPLYELSKQLTNRGVHAIHVLGFASAKDVFYEQEFSRFGRVYVATADGTRGSKGFVTDVIENEGLQFDCIMACGPTPMLKALKQRYPDKEVYLSMEERMGCGIGACFACVCHTEESETSYVKVCLDGPVFKAQEVLL
What is the function of this protein?
Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit, Dihydroorotate oxidase B, electron transfer subunit.
What is the protein family that this protein belongs to?
Belongs to the PyrK family.
Protein: DCTA_SHIFL
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGALGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDVLNNRAPDGKTHELSS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NHAA_HELAH
Sequence: MNFKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFVKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALFFLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLIYFFLNADTPSQHGFGIPMATDIAFALGVIMLLGKRVPTALKVFLITLAVADDLGAIMVIALFYTTNLKFAWLLGALGVVLVLALLNRLNTHSLIPYLLLGVLLWFCVHQSGIHATIAAVVLAFMIPVKIPKDSKNVELLELGKRYAETSSEVLLTKEQQEILHSIGEKANALQSPLEKLEHFLAPISGYFIMPLFAFANAGVSVDSNINLEVDKVLLGVILGLCLGKPLGIFLITFIGEKFKITSRPKGISWWHILGAGFLAGIGFTMSMFISNLAFTGEHKDAMEVAKIAILLGSLISGIIGALYLFLLDKKATLKK
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYY_YERPY
Sequence: MTSSNLIKQLQERGLVAQVTDEDALAERLAQGPISLYCGFDPTADSLHLGHLVPLLCLKRFQLAGHRPVALVGGATGMIGDPSFKASERKLNTEDTVNEWVEKIRHQVSPFLDFDCGENSAIAANNYDWFGGMNVLTFLRDIGKHFSVNQMINKEAVKQRLNRDDSGISFTEFSYNLLQAYDFACLNKNHGVALQIGGSDQWGNITSGIDLTRRLHQQQVYGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSLEEINALEEEDKNSGKAPRAQYVLAENVTGMVHGPEGLAAAKRITESLFSGDLHDMTEADFAQLAQDGMPTVELNRDADLQQALVNAELVPSRGQARTMIGSNAVAINGEKQADPEYVFTDADRLFGRYTLLRRGKKHYCLISWL
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCES_MONPV
Sequence: MDEIVKNIREGTHVLLPFYETLPELNLSLGKSPLPSLEYGANYFLQISRVNDLNRMPTDMLKLFTHDIMLPESDLDKVYEILKINSVKYYGRSTRADAVVADLSARNKLFKRERDAIKSNNHLTENNLYISDYKMLTFDVFRPLFDFVNEKYCIIKLPTLFGRGVIDTMRIYCSLFKNVRLLKCVSDSWLKDSAIMVASDVYKKNLDLFMSHVKSVTKSSSWKDVNTVQFSILNDPVDTEFINKFLEFSNRVYEALYYVHSLLYSSMTSDSKSIENKHQRRLVKLLL
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from late gene promoters.
What are the official names of this protein?
mRNA-capping enzyme regulatory subunit OPG124, Virus termination factor small subunit, mRNA-capping enzyme 33 kDa subunit, mRNA-capping enzyme D12 subunit, mRNA-capping enzyme small subunit.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus mRNA-capping enzyme regulatory subunit family.
Protein: AQP2_MACPR
Sequence: SIAFSRAVFSEFLATLLFVFFGLGSALNWPSTVPIPTVLQISMAFGLAIGTLVQTLGHISGAHINPAVTVACLVGCHVSFLRATFYVAAQLLGAVAGAALLHKLTPEDIRG
What is the function of this protein?
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
What are the official names of this protein?
Aquaporin-2, AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
Protein: MOTI_RABIT
Sequence: MVSRKAVAALLLVHVTAMLASQTEAFVPIFTYSELQRMQERERNRGHKKSLSVQQRSDAAAAPRPAEPTLEEENGRMQLTAPVEIGMRMNSRQLEKYRAALEAAERAVHPDAPSRPCWPAGGESGWSGEPSPT
What is the function of this protein?
Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
What are the official names of this protein?
Promotilin.
What is the protein family that this protein belongs to?
Belongs to the motilin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y811_PYRIL
Sequence: MSRVGIVSWGAYIPKYRIRTEEVAKIWGDDPLRIVDLYLVDEKSVEGIDEDAVTIAVEAAKRALKRARIDPKRIGAIYVGTESKPYAVKPISSILVDALGLSNNVFAVDMEFACKAGSEGLMAAVGLVESGRIEYGMTVGADTSQGEPGEHLEYSASSGGVALIVGRDGIVAELEAVYSFVSDTPDFWRREGSPYPMHGEGFTGEPAYFRHIIGATRGLMEKYGYKPSDFTYAVFHQPNGRFPVRVASMLNIPIEKVKPGIVVTHIGNTYNASALMGFAKILDMAKPGDKILLVPFGSGAGSNAYVFTVTDTILERQKTDVPTVEQMLRDKIYIDYAQYLKMRKMIKLFE
What are the official names of this protein?
UPF0219 protein Pisl_0811.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. UPF0219 family.
Protein: ILVD_PROMP
Sequence: MNKLRSSAITQGVQRSPNRSMLRAVGFSDEDFTKPIIGVANGFSTITPCNMGLNKLALKAEESIREAGGMPQMFGTITVSDGISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGCDKNMPGAMIAIARMNIPSIFIYGGTIKPGKLNGEDLTVVSAFEAVGQLTSGKINEKRLIEVEKNCIPGAGSCGGMFTANTMSAVIEVLGLSLPYSSTMAAEDYEKEVSAEKSAEILVDAIRKDIRPLTLMTKESFENAITVIMAIGGSTNAVLHILAIANTAGIDINIDDFERIRQKVPVICDLKPSGKYVTVDLHKAGGIPQVMKILLNTGLIHGNCRNIEGKTVVESLKDIPVKPPENQDVIRDIDNPLYKKGHLAILKGNLASEGCVAKISGIKNPVLKGPARIFESEEDCLKSILNNDIKAGNVVVIRNEGPVGGPGMREMLAPTSAIVGQGLGEKVALITDGRFSGGTYGLVVGHIAPEAAVGGNIALIKEGDLITVDATNQLIEVELSDEELEMRRINWEKPSKKYKKGVLSKYSRIVSTSSLGAVTDLEE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RL9_RICPR
Sequence: MEVILIKPVRKLGKIGDILKVADGFGRNYLLPQKLAIRATKSNKELIVKQKYEFEEKDKQVREEVEKINTIIKDQQLVFIRQTSDDCKLFGSVTNKDIADKLSKNISYNISHSNIILDKQIKSTGIYTVEIRLHAELTSIVTVVVARSESEAQDYLREQKAETLEDVDETA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: NAGZ_XANCP
Sequence: MLLIGVAGTELSAQERDWLQHDAVAGVVLFKRNFASRTQVAELSAAIRAAAPRPQLICVDQEGGRVQRFREGYSALAPLQSFGALYATDPEGALAQARAHAQLMASEVRASGVDLSFAPVVDLARGNRAIGDRAFSDDPQVVASFTRAYVQALHAAGMGATLKHFPGHGTVLEDTHVDHASDPRPLDVLLAEDLVPFVAGIDAGADAVMMAHVVYPQVAPEPAGYASRWIEQILRGQLGFRGVVFSDDIGMAASFSAGGVAGRVHAHLDAGCDVVLVCHPELVAESLQAVAGRTLNTAALIGLIGRGALGWDGLLADAPTTSLSASFGTLA
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_STRM5
Sequence: MTRKLVLLRHGQSQWNLDNRFTGWVDVDLTEQGRREAAAAGRLMREEGLQFDVAHTSVLKRAIHTLQGALAELEQDWLPVNKSWRLNERHYGGLQGLDKAETAAKHGEDQVKVWRRSYDIPPPAMDLEDPGHPIHDRRYAGLDRNALPGTESLATTLDRVLPYWHDAIAPQLKDGKTVLVTAHGNSLRALYKYLNNVSREEILELNIPTGIPLLFELNDDLTVKSFRYLGDPEAARKAAEAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.