PharMolix/UniProtQA huggingface dataset:
Protein: RL1_STRA1
Sequence: MAKKSKNLRAALEKIDSTKAYSVEEAVALAKETNFAKFDATVEVSYNLNIDVKKADQQIRGAMVLPAGTGKTSRVLVFARGAKAEEAKAAGADFVGEDDLVAKIQGGWLDFDVVIATPDMMALVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGKITYRADKAGNVQALIGKVSFDDAKLVDNFKAFNDVIVKAKPATAKGTYITNLSITTTQGVGIKVDPNSL
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: UNG_XANCP
Sequence: MTEGEGRIQLEPSWKARVGEWLLQPQMQELSAFLRQRKAANARVFPPGPQIFAAFDATPFEQVKVVVLGQDPYHGEGQAHGLCFSVLPGVPVPPSLLNIYKEIQDDLGIPRPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNREREGLVFLLWGSYAQSKGKVIDQARHRVFKAPHPSPLSAHRGFLGCKHFSKTNEHLQRRGLSPIDWSLPSRAALDLSLAGG
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_NAUPA
Sequence: MKTIEGNLQLKGNEKIAIIASRFNHLITDRLVEGAKDAFLRNGGKEENIELILVPGAFELPFGLKRAIKTGKYDGIVCVGAVIRGATPHFDYVAAEATKGIANTTLQADIPVTFGLLTTDTIEQAIERAGTKAGNKGFEAMLGLIEMINLYKEL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: MSRQ_PSE14
Sequence: MRYPFWRLAVFLAACVAPVWWLYQAWIFALGPDPGKVLVEDFGLATLVMLLITMSMTPLQRLTGWPGWIVVRRQLGLWCFAYVVLHMTMYALFILGLDLGQLGVELVKRPYIIVGALAFLGLLALAVTSNRYSQRRLGARWKKLHRLIYVILGLGLLHMFWIVRADLKEWALYAGIGAFLLLLRIPMITRRIPRLGGSAGTGSKKVQNNG
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NRDR_RHOPT
Sequence: MRCPNCNSLDTQVKDSRPTEDSSVIRRRRVCIACNFRFTTFERVQLRELIVIKRNGRRVPFDRDKLMRSVQISLRKRPVDPERVEQMVSAIVRELESGGEAEISSETIGESVMDHLRKLDDVAYVRFASVYRNFREAKDFEAVLGELSHEDEARAALVRK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: KATL2_XENTR
Sequence: MELSYQALRVASQNREAEELRTEARRKNLLILIMHYLLQEGYMDSANSLEQETKISLRRFDVCDNVDLETILMEYESYYYIKFQKYPKITKKALDHDSRVQSKPRSAGKLRRAGSNSTQGLPRIAQQTVLHRPVSGSYFRTHAHQKALSRENSKQENGGNSPREASEIGLNVSAISKTSGEGGQTRRRQVIDFRSMIQDTIKGASQEIALNSLNCNPDPSERLIKPVGAFIGGNSEMRELAAVISRDIYLQNPNVRWDDIIGLDAAKRLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECNTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTGPGGEHEGSRRMKTELLVQMDGLARSDDLVFVLAASNLPWELDYAMLRRLEKRILVDLPSKEARQAMIQHWLPPVSNSSGVELRTDLDYSTLGAETDGYSGSDIRLVCKEAAMRPVRKIFDALENHHSEHKNLPVISLDTVTTSDFLEVLAHTKPSAKSLAEKYAAWQKEFESV
What is the function of this protein?
Severs microtubules in vitro in an ATP-dependent manner.  This activity may promote rapid reorganization of cellular microtubule arrays.
What are the official names of this protein?
Katanin p60 ATPase-containing subunit A-like 2, Katanin p60 subunit A-like 2, p60 katanin-like 2.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.
Protein: RL34_ACTSZ
Sequence: MKRTFQPSVLKRSRTHGFRARMATKNGRQVLARRRAKGRKSLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: CCA_YERE8
Sequence: MKTYLVGGAVRDSLLNLPVTEQDWVVVGATPEQLLAQGYQQVGKDFPVFLHPVTHEEYALARTERKSGQGYTGFTCYAAPDVTLEEDLLRRDLTINAIARSSEGELFDPYNGQQDIEKRVLRHVSDAFGEDPLRVLRVARFAARFAHLGFTVASETQSLMAAMAKSGELSALTPERVWKETEKALKTQSPQIYFQVLRDCGALAVLFPEIECLFGVPAPEKWHPEIDTGIHTLMTLAMTAQLSPEVDVRFAALCHDLGKGLTPKEFWPHHHGHGPAGVKLVEQLCQRLRVPNPVRDLAKLVAEYHDLIHTVNKLRPETLLKLFDAIDVWRKPERLEQMIMTSEADARGRTGFEENPYPQGDYLRAAFRIANGVSVQEVVASGLQGLAIRDELKRRRQQALAEWKLTQEVISPLN
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: SECB_ALISL
Sequence: MAEAAQQEQQNFAIQRIFLKDVSFEAPNSPNMFQKEWNPDVKLDLDTQSRELGEGVYEVILRLTVTVKNEEETAFLCEVQQGGIFTAGQMEEAQLAHCLGAFCPNILFPYARETISSLVVKGTFPQLNLAPANFDALFMNYLQNQASETAEAPAEAPAEA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_BURP1
Sequence: MVIIRLARGGSKKRPFYNIVATDSRNRRDGRFIERVGFYNPVATKGEALRIAQDRLTYWQGVGAQLSPTVERLVKQAQKAQPAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RL23_CLAMS
Sequence: MSATQKDPRDIIIAPVVSEKSYGLIDQGKYTFIVDPRSNKTEIKLAIEKIFGVQVASVNTLNKQGKTRRTKFGMGKRKDTKRAIVSLKSGSIDIFTTVG
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: CALB_CAUVC
Sequence: MNAPVNLSSDAHKAVMNDVLQRQKAAHLRDGPPSAEKRIQWLNRCIDLLVGHQAEIAKAVNQDFGSRSPEATSLTDVAGSIGPLKHAREHLTKWMKPEKHKTTPAILGLFGAKATVQWQPKGVVGVISPWNFPVNLTFAPLAGVFAAGNRAMIKPSEFTPATSDLLKAMFAKAFNEEEVAVFVGGPEVGQAFSGLAFDHLVFTGATSVAKHVMRAAAENLVPVTLELGGKSPVILSRGADMATAAARVMNGKTLNAGQICLAPDYVLAPQEDVEAFVKEAQAAVSRYFPTIKDNPDYTAVVAQRHYDRVKGYVDDARAKGARVIEINPAGEDLSQQEHRKIPPTLILDPTDDMKVMQEEIFGPVLPVKGYKTVDEAVDYVNAHDRPLALYWFGTDEAEKDRVLERTTSGGVTVNDVIFHVAQENLPFGGIGPAGMGAYHGYDGFREFSHRKAVFQQLKKDIAPMLGLRPPYGEGIRKYLAGQIKK
What are the official names of this protein?
Probable coniferyl aldehyde dehydrogenase, CALDH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: LIPB_GRAFK
Sequence: MNKEVEVRNLGIKDYKETWDYQENIFKETVDLKIKNRREGTEIPTRNYFLFVEHPHVYTLGKSGDAENLLISEKELKAKNATFYKINRGGDITYHGPGQIVGYPILDLDNFFTDIHKYLRLLEEAVILTLSEYGLKSERSPGETGVWLDVGTPFARKICAMGVRASRWVTMHGFALNVNADLGYFDNIIPCGIKGKAVTSLNVELGQKEINLEEVQEKLLKHFQELFQAELKYQ
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_PHOLL
Sequence: MIKVYAPASIGNVSVGFDVLGAAVSPVNGALLGDCVTVRAAKSFSLRNEGQFVGKLPEKLEHNIVYQCWQLFCQHLGKQLPVEMTLEKNMPIGSGLGSSACSVVAGLMALNEFAGLPFNESQLLAMMGELEGRISGSIHYDNVAPCYLGGLQLIMEQGDIICQPVPSFDEWLWVMAYPGIKVSTAEARAILPVKYSKQDVIDHGRFLAGFIHACHTRQPALAARLMKDVVAEPYRTQLLPGFANARETAKRVGALACGISGSGPTLFSICNDIATAEEIAEWLQQHYVQNDEGFVHICRLDLAGARQIG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_WIGBR
Sequence: MNTYEGKLQSKNSKIAIIISRFNSFINKNLLDGAIDSLKRIGRLKSENISIFWVPGVCEIPIIVNFLSKQNKYNGLITLGTVIQGKTFHHELISKDFNNIIFNISIKKNIPISVGVLYTRNINQAIERSGTKLGNKGSDAALSVLEMINLLKII
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: GLYC_CANAL
Sequence: MSAYALSQSHRQLTEGHLKDTDPEVDQIIKDEIDRQQHSIVLIASENFTTTAVFDALGTPMCNKYSEGYPGARYYGGNEHIDRMELLCQERALKAFGLTPDKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLDLPHGGHLSHGYQTDSRKISAVSTYFETMPYRVDLETGLIDYDMLEKTAVLYRPKVLVAGTSAYCRLIDYKRMREIADKVGAYLVVDMAHISGLIAAGVIPSPFEYADIVTTTTHKSLRGPRGAMIFFRRGVRSVNPKTGQEILYDLENPINFSVFPGHQGGPHNHTIAALATALKQANTPEFKEYQEQVLKNAKALESEFTKKGYKLVSDGTDSHMVLVSLKDKQIDGARVETVCEKINIALNKNSIPGDKSALVPGGVRIGAPAMTTRGLGEEDFKKIVSYIDFAVNYAKEVQSQLPKDANKLKDFKNAVSGDSEKLKAVRDEIYQWAGSFPLAV
What is the function of this protein?
Interconversion of serine and glycine.
What are the official names of this protein?
Serine hydroxymethyltransferase, cytosolic, SHMT, Glycine hydroxymethyltransferase, SHMII, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSP_PLAFT
Sequence: MMRKLAILSVSSFLFVEALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNNNGDNNREGKDEDKRDGNNEDNETLRKPKHKKLKQPGDGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNNNEEPSDKHIEQYLKKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYENDIEKKICKMEKCSSVFNVVNSSIGLIMVLSFLFLN
What is the function of this protein?
In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
What are the official names of this protein?
Circumsporozoite protein, CS.
What is the protein family that this protein belongs to?
Belongs to the plasmodium circumsporozoite protein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasm. Note=Localizes to the cytoplasm and the cell membrane in oocysts at day 6 post infection and then gradually distributes over the entire cell surface of the sporoblast and the budding sporozoites.
Protein: AN32E_HUMAN
Sequence: MEMKKKINLELRNRSPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEEEGGLRGEKRKRDAEDDGEEEDD
What is the function of this protein?
Histone chaperone that specifically mediates the genome-wide removal of histone H2A. Z/H2AZ1 from the nucleosome: removes H2A. Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions.  Not involved in deposition of H2A. Z/H2AZ1 in the nucleosome.  May stabilize the evicted H2A. Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511).  Inhibits activity of protein phosphatase 2A (PP2A).  Does not inhibit protein phosphatase 1.  May play a role in cerebellar development and synaptogenesis.
What are the official names of this protein?
Acidic leucine-rich nuclear phosphoprotein 32 family member E, LANP-like protein, LANP-L.
What is the protein family that this protein belongs to?
Belongs to the ANP32 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RPC_BP163
Sequence: MHKGTFHMSRLTDTLAAKLEEAGITQAELARRVGQSQQAINNLFAGRAASSMVWRELARELGIDEQEMRQMMTEAGRDPEKVTSLAGLRKYRAVLPSPREPFPIIRQQEHLPRPNATIGEETNMEPRKKKLLPVLGEAVGGEDGEYIFNGSVLDYVDCPPSLENVPNAYAVYIDGESMVPRFRPGETVWVHPTKPPRRGDDVVIQIHPDNEDDGAPPRGFVKEFVGWTANKLVLQQYNPTKKIEFTREQVVSVHPIILAGKYW
What are the official names of this protein?
Repressor protein C.
Protein: PYRG_METMP
Sequence: MKYIFVTGGVVSSLGKGITSSSLGRLLKARGLNVNMIKIDPYLQIDAGTMSPFEHGEVFVTDDGGETDLDLGNYERFVDIGLKADNNITTGKIYWSVLSKERKGDYLGKTVQVIPHITNEIKDRIKNLGKESDITIIEIGGTVGDIESLPFLEAIRQFKKDVGKENVLYIHVSLLPYIRSAGELKTKPTQHSVKELKGIGIQPDILVCRSEIPISEKIKDKLALFCDVEKEAVIECKDARTIYEVPLNLEKEGLGKLVTEKLNLRDSTPDLTEWRAIVDRIINPMNEITIGIVGKYIELKDSYMSIMEALGHAGAKNDTKVNIAWINSEELETKNYEEILNKMVDDEKLHGILVPGGFGDRGIDGKVNAVRYAREKNIPFLGICLGMQCAVIEFARHVCGLNANSTEFDEETEHPVIDYIPEQREVTEKGGTMRLGAYPAVLTENSLASELYGSINASERHRHRYEVNPEYHEILKKNGLIISGMSPDGKLAEFIELENHKYFIATQAHPEFKSRPNKPHPLFHGLVKASIEK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: CYB_ORYSJ
Sequence: MTIRNQRFSLLKQPIYSTLNQHLIDYPTPSNLSYWWGFGSLAGICLVIQIVTGVFLAMHYTPHVDLAFNSVEHIMRDVEGGWLLRYMHANGASMFFIVVYLHIFRGLYYASYSSPREFVWCLGVVIFLLMIVTAFIGYVLPWGQMSFWGATVITSLASAIPVVGDTIVTWLWGGFSVDNATLNRFFSLHYLLPFILVGASLLHLAALHQYGSNNPLGVHSEMDKIAFYPYFYVKDLVGWVAFAIFFSIWIFFAPNVLGHPDNYIPANPMSTPPHIVPEWYFLPIYAILRSIPDKAGGVAAIALVFISLLALPFFKEMYVRSSSFRPIYQGIFWLLLADCLLLGWIGCQPVEAPFVTIGQISSFFFFLFFAITPILGRVGRGIPKYYTDETHRTGSVS
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HEM3_DESRM
Sequence: MKHKITVGSRDSALALWQTRWVVEQLEKQNPDVTFEITTMKTKGDKMLDVALAKIGDKGLFTKELEVAMLQKEIDFAVHSLKDMPTALPEGLIIGAVCKRDNPGDALISKDGRKLDELPKGARIGTSSLRRCAQLLNYRPDFQLEALRGNLNTRMKKLVSEQLDGIILAAAGITRMGWEDMIAEIIPFQVCLPAVGQGAISVECREDDPEILNLLKGIEHTETKAATEAERSLLRYLEGGCQVPIGAHSEVKNNRLMLTAVVATLDGTKVIRAQGENEVNKAVELGIEVAEKLMAMGGKKILEEVRAGE
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: DGLA_MOUSE
Sequence: MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSHEMLRYKEVCYYMLFALAAYGWPMYLMRKPTCGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHRGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEDQVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPLPTGLALELPATEHRNSSVRSKSQSEMSLEGFSEGRLLSPVAAASAARQDPVELLLLSTQERLAAELQSRRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSATIEEEEAAGGSEGGGVAPRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSDYTEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSAEPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLATDKIRTSTPTGHGASPTKQDDLVISAR
What is the function of this protein?
Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid (eCB), 2-arachidonoylglycerol (2-AG) (PubMed:17584991, PubMed:23103940).  Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG.  Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:17584991).  Plays a key role in regulating 2-AG signaling in the central nervous system (CNS) (PubMed:20159446, PubMed:20147530, PubMed:25466252, PubMed:26668358, PubMed:26779719).  Controls the activity of 2-AG as a retrograde messenger at neuronal synapses (PubMed:20159446, PubMed:20147530, PubMed:26668358).  Supports axonal growth during development and adult neurogenesis (PubMed:20147530).  Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors (PubMed:25466252).  Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (PubMed:26779719).
What are the official names of this protein?
Diacylglycerol lipase-alpha, DAGL-alpha, DGL-alpha, Neural stem cell-derived dendrite regulator, Sn1-specific diacylglycerol lipase alpha.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Postsynaptic density membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Note=Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner.
Protein: RS20_LIMRD
Sequence: MPIIKSAIERVRTSEKAEARNASQLSQMRTAIKKFDKAKLAGADNLDDLYKAAISAIDRAHSKGLIKANKAARDKSRLSARYAK
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: YICN_ECO57
Sequence: MIWIMLATLAVVFVVGFRVLTSGARKAIRRLSDRLNIDVVPVESMVDQMGKSAGDEFLRYLHRPDESHLQNAAQVLLIWQIVIVDGSEQNLLQWHRILQKARLAAPITDAQVRLALGFLRETEPEMQDINAFQMRYNAFFQPAEGVHWLH
What are the official names of this protein?
Uncharacterized protein YicN.
Protein: RADA_PYRFU
Sequence: MAGEEVKEIDEFEELGFEPATEETPKKKKKEKIIRSIEDLPGVGPATAEKLREAGYDTLEAIAVASPIELKEVAGISEGTALKIIQAARKAANLGTFMRADEYLKKRATIGRISTGSKSLDKLLGGGIETQAITEVFGEFGSGKTQLAHTLAVMVQLPPEEGGLNGSVIWIDTENTFRPERIREIAQNRGLDPDEVLKHIYVARAFNSNHQMLLVQQAEDKIKELLNTDRPVKLLIVDSLTSHFRSEYIGRGALAERQQKLAKHLADLHRLANLYDIAVFVTNQVQARPDAFFGDPTRPIGGHILAHSATLRVYLRKGKGGKRIARLIDAPHLPEGEAVFSITEKGIED
What is the function of this protein?
Involved in DNA repair and in homologous recombination.  Binds and assemble on single-stranded DNA to form a nucleoprotein filament.  Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
What are the official names of this protein?
DNA repair and recombination protein RadA.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RecA-like protein family.
Protein: RS18_HELPS
Sequence: MERKRYSKRYCKYTEAKISFIDYKDLDMLKHTLSERYKIMPRRLTGNSKKWQERVEVAIKRARHMALIPYIVDRKRVVDSPFKQH
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RS3_STRPI
Sequence: MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFVQKELADAAVSTIEIERAVNKVNVSLHTAKPGMVIGKGGANVDALRAKLNKLTGKQVHINIIEIKQPDLDAHLVGEGIARQLEQRVAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGADIARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.