PharMolix/UniProtQA huggingface dataset:
Protein: TRMB_GEOTN
Sequence: MRLRNKPWAKDKIAAYPQYVIPDPEARRGRWHELFGNDRPIHIEIGTGKGKFITEMAKLHPDVNFIGIELYPSVLVSALDKLIESELPNVRLLNANAKDLTSFFADGEIARIYLNFSDPWPKKRHEKRRLTYRDFLALYDRILSADGDIHLKTDNQSFFEYSLVSLSQYGFVLAAVQLDLHRSDIVGNVMTEYEEKFSAKGNRIYRCEALRPPQQS
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RIMO_CALS8
Sequence: MVKVGFVSLGCNKNLVDSEIMMGACKEAGFEITPNAEDADVIVINTCGFINDAKQESIDTILEMAEYKNKKCKFLIVTGCLSQRYKDDILKELPEVDAILGVKEMLKLPNVIKKLYEGESKLQVFDDKPTFVYTSSMPRLIATPKFYAYIKIAEGCNNRCSYCSIPLIRGNYTSRYIDDIIQEARKLSEDGYKEIVLTAQDTTKYGIDIYQKKMLATLLQKLSEIDNIKWIRFLYSYPEDIDDELLNIVKSLPKVVKYFDIPIQHINNRILKLMNRKTSSEGIKELIQRIRSAFDEVVIRTTVMVGFPTESEDEFEELYEFVKWAKFDRLGAFMYSQEEGTPAADLPQTDDETKVKRYERILNLQRKISLERNRKRISKKYEVVIEGRDRNNFYIARSQFEAPEVDGKIIVFSKRKLLPGEFVVVKILDAFEYDLVGEVI
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAKD3_MOUSE
Sequence: MAFITLRRAFCHKSILWIPGAVVALKIHPASHAPKAVTDRLSVCFCSLQPELFRVRFHHAYCKNFHSEKGNDFHPVGEPWSSQAQEWNQPGQSLQNEDEEMLFRRLSYFTSFEEVLSFISALDTLPVPLAMAALLRICEIGRRDGEQRLPEGVLENRAFQALCLRCERDPSHLTNAGLVTALQSLLTLLPADPQSSLMLSLVAECQRRLQRGNLEVHHLCVLGESLAMLQGASCETLKLVVRQLQSKSVETFAPEEITSVYRILQVCPEEVDKHQMFLNTLNNFSISVVPYLSPKSISHVLTALVALDQTHALPLLIKLGKYVVRYIPRFTNEELRKVLEAFVYFGHSDRFFTEALEQHVSALCFSLDPAVASSVMGYCSRKRILSKPIFDVVSEIVVCQWDRLSPSQIAELIEPFGKLNYVPPNAPALFRKVENVLCARLHHFPPKMLLRLLHSCALIERHPVNFMSKLFSPFFLQRLQGKESYLDRLSLAQLTQLFLTSVLECPFYKGPKLLPKYQVKSFLTPCCSLETPLDLHLYKSVVIGLIDLLGSRLYFASKVLTPYYYTIDVEVKLDEDGFVLPCTVDEDIHKRVALCIDGPQRFCLDSKHLLGKEATKQRHLRLLGYQVVQLPYHELELLTSRLELVDYLQRKLFSQSSAVHW
What is the function of this protein?
Required for normal mitochondrial respiration.  Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6.  Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity.
What are the official names of this protein?
FAST kinase domain-containing protein 3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the FAST kinase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MOEA_SYNE7
Sequence: MILSYSAAIELLLAEVAQLPLAIERVPLLETGDRLLAKDLAAPCDLPHWDNSAMDGFALRSQDVAAASPDRPVRLPVVGRVMAGEQPPLLANPTGVACAVMTGAPIPAGFDVIVKVEDVVQEENAIAVSTPIPAGQFIRRQGEDLRQGSPLLAKGQRLTPMALMLAAAVGMGELPVWSKLPVGLISTGTEVVPWSQPTLELGQIRNSSQPFLIEQLQRLGCEVRAIAHVPDDPEQFAAIAQQFWSQGVRLLLTTGAVSMGVADFVPAALERLGCQTIFHKVAIRPGKPLLFAIAPEHQGLVLACPGNPVSTTVTAEFFLKPLLMACRNEVRSPLWLPLAESVRKPEGLQCFWRSRLTPEGKVWVDPQQSSAALKSLVESTHWAILPAGQDFLAAGTPVEVRSL
What is the function of this protein?
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
What are the official names of this protein?
Molybdopterin molybdenumtransferase, MPT Mo-transferase.
What is the protein family that this protein belongs to?
Belongs to the MoeA family.
Protein: NADK_CAMJE
Sequence: MQNKIDYKNIKKIGLVTRPNVSLDKEILKLQSILSIYKVELVLLKESSEILDLPKYGLDDLFKISDFVISLGGDGTLISLCRKACEYDKAVLGIHAGHLGFLTDFKVDEAENFFQAFFQGEFRIEKPYLLSIFLEDRQGKILEKLAFNDVVISKNNQASMAHIEVFRKEKKFNEYFGDGLIVATPAGSTAYNLSANGPIVYTLAQAFILTPVCSHSLTQRPIVLPKGFEIEIMAKDCMLCIDGQENYKMNDFKSIKVGLSDKNVALIHPKNRDYFQILKEKLHWGN
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISDC_STAA1
Sequence: MKNILKVFNTTILALIIIIATFSNSANAADSGTLNYEVYKYNTNDTSIANDYFNKPAKYIKKNGKLYVQITVNHSHWITGMSIEGHKENIISKNTAKDERTSEFEVSKLNGKIDGKIDVYIDEKVNGKPFKYDHHYNITYKFNGPTDVAGANAPGKDDKNSASGSDKGSDGTTTGQSESNSSNKDKVENPQTNAGTPAYIYAIPVASLALLIAITLFVRKKSKGNVE
What is the function of this protein?
Involved in heme (porphyrin) scavenging.  Binds hemoglobin and almost exclusively free-base protoporphyrin IX.  Probably has a role as the central conduit of the isd heme uptake system, i. e.  mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF.  Hemin-free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor.  The reaction is reversible (By similarity).
What are the official names of this protein?
Iron-regulated surface determinant protein C, Staphylococcal iron-regulated protein D.
What is the protein family that this protein belongs to?
Belongs to the IsdC family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan- anchor. Note=Anchored to the cell wall by sortase B (By similarity).
Protein: PB1F2_I02A5
Sequence: MEQGQDTPWTQSTEHTNIQKRGSGQQTQRLEHPNSTRLMDHYLRIMSPVGMHKQIVYWKQWLSLKNPTQGSLKTRVLKRWKLFNKQEWIN
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: DEF6_HUMAN
Sequence: MRTLTILTAVLLVALQAKAEPLQAEDDPLQAKAYEADAQEQRGANDQDFAVSFAEDASSSLRALGSTRAFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL
What is the function of this protein?
Host-defense peptide that contributes to intestinal innate immunity and mediates homeostasis at mucosal surfaces by forming higher-order oligomers that capture bacteria and prevent microbial invasion of the epithelium (PubMed:15616305, PubMed:25158166, PubMed:25354318, PubMed:28026958, PubMed:17088326).  After binding to bacterial surface proteins, undergoes ordered self-assembly to form fibril-like nanonets that surround and entangle bacteria and thereby prevent bacterial invasion across the epithelial barrier (PubMed:22722251).  Entangles and agglutinates Gram-negative bacteria, such as E. coli, S. typhimurium and Y. enterocolitica, and Gram-positive bacteria such as L. monocytogenes, thereby protecting the intestine against invasion by enteric bacterial pathogens (PubMed:27076903, PubMed:25158166, PubMed:22722251).  Blocks adhesion of C. albicans to intestinal epithelial cells and thereby suppresses fungal invasion of epithelial cells and biofilm formation (PubMed:28026958).  Under reducing conditions and in an acidic environment similar to the intestinal milieu, exhibits inhibitory activity against anaerobic bacteria such as B. adolescentis, L. acidophilus and B. breve, as well as B. longum and S. thermophilus, possibly by leading to alterations in bacterial cell envelope structures (PubMed:25354318).  The disulfide-linked oxidized form exhibits negligible antimicrobial activity against Gram-negative and Gram-positive bacteria, as compared to the enteric defensin DEFA5 (PubMed:15616305, PubMed:17088326).
What are the official names of this protein?
Defensin-6, Defensin, alpha 6.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored as propeptide in secretory granules of small intestinal Paneth cells and found in the ileum lumen as mature peptide.
Protein: RL16_BURPS
Sequence: MLQPKRRKYRKEQKGRNTGIATRGNAVSFGEFGLKAVGRGRLTARQIEAARRAMTRHIKRGGRIWIRIFPDKPISQKPAEVRMGNGKGNPEYYVAEIQPGKMLYEMDGVSEELAREAFRLAAAKLPLKTTFIVRQLGA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: SPA_STAAU
Sequence: MKKKNIYSIRKLGVGIASVTLGTLLISGGVTPAANAAQHDEAQQNAFYQVLNMPNLNADQRNGFIQSLKDDPSQSANVLGEAQKLNDSQAPKADAQQNKFNKDQQSAFYEILNMPNLNEEQRNGFIQSLKDDPSQSTNVLGEAKKLNESQAPKADNNFNKEQQNAFYEILNMPNLNEEQRNGFIQSLKDDPSQSANLLAEAKKLNESQAPKADNKFNKEQQNAFYEILHLPNLNEEQRNGFIQSLKDDPSQSANLLAEAKKLNDAQAPKADNKFNKEQQNAFYEILHLPNLTEEQRNGFIQSLKDDPSVSKEILAEAKKLNDAQAPKEEDNNKPGKEDGNKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDGNKPGKEDGNKPGKEDGNKPGKEDGNGVHVVKPGDTVNDIAKANGTTADKIAADNKLADKNMIKPGQELVVDKKQPANHADANKAQALPETGEENPFIGTTVFGGLSLALGAALLAGRRREL
What is the function of this protein?
Plays a role in the inhibition of the host innate and adaptive immune responses.  Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins (By similarity).  In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region.  In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production.  Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin.  Acts directly as a pro-inflammatory factor in the lung through its ability to bind and activate tumor necrosis factor alpha receptor 1/TNFRSF1A (By similarity).
What are the official names of this protein?
Immunoglobulin G-binding protein A, IgG-binding protein A, Staphylococcal protein A, SpA.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin-binding protein SpA family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A.
Protein: ELOA1_CAEEL
Sequence: MPETDEEKVRRYTECLMNGIDPKRALKRLYDLNVSPEVFKSADTYQCVKRYESSPELAKYAKRVRDKLLGGRKREKGGGEDDADIEHTALKKAKKEEVNLDEEFAEAMKSGVSAQASSAPRATVDYSKYKVVKRVEVKVEPKPEPVDVHEQQASSSSMSYQREHQKDYAPVVPTCKPSGQPKKAIPQSKSLHADENMFKPRKERQKVFAGRRKRVGEGVSTLVSLCQTVLMSHIDMIDHVGIVPFDLLKPVLDHASTDQLRHILDVNPMLVEDADEMFHEMVSREFPKYANREKSGWTWREMYDRLVEKKQKKENDKLEMLTSRIGKSNSAQSQGRQTMVIDMAHTRVRSKSFFNTVKDSQVKMSATPSALQLSQARKNVKIEGKAQLRTITPRGGGVPSTSRSRSNNNNNMNNGLVVKKTAPLMAKCKKMLKR
What is the function of this protein?
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites.  Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
What are the official names of this protein?
Transcription elongation factor B polypeptide 3, Elongin-A, RNA polymerase II transcription factor SIII subunit A.
What are the subcellular locations of this protein?
Nucleus.
Protein: YQGF_LACJO
Sequence: MRLLGLDVGSKTVGVAISDPLGITAQELETIKIDESKFSFGLRQIRRIVRKYDVEGFVLGLPKNMDGSSGHSVERSKQYGERLKEKFDLPVYYMDERLTTVQADRILVEEAGVHDRVERKKVIDQMAAVLILQNYLEATRKDN
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_NEIMF
Sequence: MSNTIKMVVGLGNPGKEYEQTRHNAGFWFLDELAWKWKASFKEEKKFFGEVARAALPDGDVWLLKPATFMNRSGQAVAALAQFYKIKPEEILVVHDELDIPCGRIKFKLGGGNGGHNGLKDIQAKLGTADYYRLRLGIGHPGDRNLVVGYVLNKPSTEHRRQIDDAVAKSLQAIPDILAGKWEEATRFLHSK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_MESH2
Sequence: MKAKINFLNQSRIKFKYLKLFRKIFKLLVEKEQITGEISLDLMLITQRKAQKLAIKFKNINYIPDVLSFPSNLIIAKKNFRLHFLGEIFMTPAKIIKQANEYGHSEEREFSYLFVHSIYHLLGFDHQDEKTNKLMDEKVENILINLGINR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTLL6_HUMAN
Sequence: MPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKKKRKKKRLVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICKPDSGCQGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGLARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGSKRKLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCCSREMRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHLTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRSHASAMRDPCMQDQEAYSHCLISGQKGCERS
What is the function of this protein?
Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins.  Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction.  Preferentially modifies the alpha-tubulin tail over a beta-tail.  Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions.  Mediates microtubule polyglutamylation in primary cilia axoneme, which is important for ciliary structural formation and motility.  Mediates microtubule polyglutamylation in motile cilia, necessary for the regulation of ciliary coordinated beating.  Polyglutamylates non-tubulin protein nucleotidyltransferase CGAS, leading to CGAS DNA-binding inhibition, thereby preventing antiviral defense response.
What are the official names of this protein?
Tubulin polyglutamylase TTLL6, Protein polyglutamylase TTLL6, Tubulin--tyrosine ligase-like protein 6.
What is the protein family that this protein belongs to?
Belongs to the tubulin--tyrosine ligase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Note=CEP41 is required for its transport between the basal body and the cilium axoneme.
Protein: SECE_AQUAE
Sequence: MEKLKEFLKGVRDELKRVVWPSRELVVKATISVIIFSLAIGVYLWILDLTFTKIISFILSLRGSL
What is the function of this protein?
Essential subunit of the protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: C8AP2_MOUSE
Sequence: MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSAVSDSTARSCVSFRNCLDLYEEILTEEGTAKEATYNDLQIEYGKCQQQMKDLMKRFKEIQTQNLNLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSQSTSPHLDDCSKTDHGVKSDVQKDVHPNTAQPNLEKEGKSHSEAQNPLHLSTGVEKHCANNVWSRSPYQVGEGNSNEDNRRGRSGTRHSQCSRGTDRTQKDLHSSCNDSEPRDKEANSRLQGHPEKHGNSEARTESKISESKSSTGMGYKSERSASSWEKETSRERPHTRVESQHDKNLEKQNERLQNMHRKELPSQDKTERKVDVKFKPAGEEQGHRGRVDRALPPHPKNDVKHYGFNKYHPEERRGREDCKRDRGMNSHGFQDRRCSSFLSSNRNSKYPHSKEVSVAHQWENTPFKAERHRTEDRRKRERENKEESRHVKSDKKSPPEHLQRTHKDTKKSTADGKRQTEPKHGKGAVSNSELSKGTDSKEGATKVESGPNEAKGKDLKLSFMEKLNLTLSPAKKQPACQDNPHQITGVPEPSGTCDSRSLETTGTVACLPSGSEHNREETKSELPEPKEALLATSQLRISIPENKMKEEKRLLFKSVENTVPCELLACGTEISLPAPVEIEQARCLLGSVEVEETCGGARTAASVVMHVLPEHASEDASQELDTKRHDGINACAISEGVKTKVILSPKAAAASESHLAPLVEEPSISLVNCSGDNNPKLEPSLEERPIVETKSCPLESCLPKETFVPSPQKTELIDHKIETGESNSVYQDDDNSVLSIDFNNLRPIPDPISPLNSPVRPVCKVVSMESSCAIPLYDSSHKDEFPSNSTLSTFKSQSDLNKENEKPVPKFDKCSEADSCKHLSLDELEEGEIRSDDEESVAQKRLEKSARPRVSAEVQPGKSSPGSRRSTVHVHKDNGRTAVKLPRDRLTWSKRSSESRPSNTERKSKTMSISSLEKILPLILVPSSLWEVMHMLRLLGKHVRKNYMKFKIKFSLTQFHRIIESAILSFTSLVKCLDLSKICKSVSTLQKSLCEVIESNLKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQLDYLFEKLKKILLKFCDSVNFENENSEGKLGKKYKERTQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKSEEKHQDQNKTNASIVKHDVKRTFSTCSDNTKNAECKEQFLEKSCPSTPRPGKDEGHTEEEAQAAQHASAKSERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDTSGTEKAEWELKTPEKQLLESLKCESAPACATEELVSEGASLCPKVISDDNWSLLSSEKGPSLSSGLSLPVHPDVLDENCMFEVSSNTALGKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGHLSFLKPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTSRSVASGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSPGLKHGVVAEESLTSLPRTGKEAGVATEKEPNLFQSTVLKPVKDLENTDKNIDKSKLTHEEQNSIVQTQVPDIYEFLKDASNKVVHCDQVVDDCFKLHQVWEPKVSENLQELPSMEKIPHSLDNHLPDTHIDLTKDSATETKSLGELMEVTVLNVDHLECSQTNLDQDAEITCSSLQPDTIDAFIDLTHDASSESKNEGSEPVLAVEGMGCQVICIDEDTNKEGKMGRANSPLESIVEETCIDLTSESPGSCEIKRHNLKSEPPSKLDCLELPETLGNGHKKRKNSPGVSHSSQKKQRKDIDLSSEKTQRLSPNSDRNGDAHRKQASKKREPAVNETSLSSEASPEVKGSTAVLAASPASLSAKNVIKKKGEIIVSWTRNDDREILLECQKRMPSLKTFTYLAVKLNKNPNQVSERFQQLKKLFEKSKCR
What is the function of this protein?
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B.  Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (By similarity).  Required for histone gene transcription and progression through S phase (By similarity).  Required for histone gene transcription and S phase progression (By similarity).  Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway.  Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B.  Required for the activation of CASP8 in FAS-mediated apoptosis.
What are the official names of this protein?
CASP8-associated protein 2, FLICE-associated huge protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.
Protein: Y5610_BURCH
Sequence: MNTTPDTPTPRALRELTPLEARILGVLVEKQHTVPDTYPLSLNALTAGCNQKTARAPVMNVSEDEVTTALDELKRLSLVMEGSSSRVPRFEHNMNRVLGIPSQAIALLTILLLRGPQTAAELRLNSARLHGFADISSVEAFLDELAARAQPLVVRLPRAPGARENRWMHLMCGDVNMADFASADAGGGADSVPPSEFEALKAEQKRLADEVARLNALVQRMASELGIDVDAPGDAS
What are the official names of this protein?
UPF0502 protein Bcen2424_5610.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: GLMU_SALA4
Sequence: MLNSAMSVVILAAGKGTRMYSDIPKVLHTLAGKPMVQHVIDAATKLGAAQVHLVYGHGGELLKQTLKDDKLNWVLQAEQLGTGHAMQQAAPFFSDDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPSGYGHITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADLKRWLSKLTNNNAQGEYYITDIIALAYQEGREIAAVHPARISETDGVNNRLQLSRLERIYQAEQAEKLLLSGVMLRDPARFDLRGTLHCGMDVEIDANVIIEGYVTLGHRVKIGAGCIIKNSVIGDDCEISPYSVVEDAHLEAACTIGPFARLRPGAELLAGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTVIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVADNELVLSRVPQVHKQGWQRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_RHOP5
Sequence: MTPAPKSSFVLGHRHLLGIEGLSAADISGLLDLSEEYVELNRQVDKKRTSLRGRTQVNLFFEASTRTQSSFEIAGKRLGADVMNMSVSSSSMRKGETLMDTAVTLNAMHPDILVVRHHASGAVELLARKVDGSVINAGDGAHEHPTQALLDALTIRRNKGRIEGLTVAICGDVMHSRVARSNILLLGIMGARVRVVAPSTLLPPGIERMGVEVARDMREGLNGADIVMMLRLQRERMNGSFVPSSQEYFQYFGLDQKKLAYANPDALVMHPGPMNRGVEIDSAVADGAQSLIREQVEMGVAVRMAVLEALARNLPNA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: FORF_DICDI
Sequence: MNRIFGRKKKDKDSDEKGSTESENDFLSSLPAKANKRYSMAYSSLQPDGNNSTNSKSADKFDDKGKAVDTPEFFVNTINLLPNIEILAQLCSSLQSKPSAWSKSLIDCNGIEALLNVLAFIERNGQKDSDVILQSLAVTCLLSLLNSKYGIEKAIATPNSMIRLITSMDTPKADTRSSVFEILTAICMISEKGYQLILEAMTHFKQVRKERFRFTFLVESMKKVMNSSDKEYLTTCLTLVNGIVNSSEEIDERIQLRTEFTRLGLDEVISVNKNIPYEEAPDLLTQIDVYEDEQRADQEELSERFEDLDIDINDPQVIFNEIYKQAKDRLHHPLLAILQSLLSISSDTEVGMLSWFLIEKLVLQISVNKPMIGDDDGKVSLEDLLASTAPSVALQSEFQKNIEELAKVKDQLKKANFDLNIANQELSSRSHESSVLKSNMFNTVKQKDQEIIKLRGQMKRIDSNFFSPPGGDGDDHINVINTPEESSPHHESPRKQQQQTSKPPLNPKSSKPPISSSQLKEKSKSNLSSSSSDSLSNDFKSQVEVAQQQQPQQQNIESTLTPEPTQIIKEEPIVTTPPPAPPAPPPPPMMGGGPPPPPPPPMMGGGGPPPPPPPPMMGGGPPPPPPMGGKGGPPPPPGGGGFGLFNSNKPPANAPKFTVSKPTTKVKQFQWTKIPNKKLGETIFTNLGTIKTDWLNVGEIENLFFAPEANSQKKLEASDKKSTSSTKPGTVSVIDPKKSQNLAIYLSKFKCPLEEIKTALYTLDEDIFTMESLKALEQYLPTDEDMEAIKDYLKKDGELKMLTKAEHFLLEMDSVSSLAERVKSFYLKILFPDKLKEIKPDLELFTKTIKDIKNSKNFLKVMEVVLIIGNFLNGGTARGDCFGFKLDALLKLADTKTANNKSNLLVYIISELEQKFPDSLKFMDDLSGVQECVKISMNTISADLNLLKKDLDAVNNGIGKMKRSKEESYFFSTMDDFIKDANIEIKIAFDQFQEAEKNFQELAVLFGEESKIPSEEFFVTINRFIVMFDKCYKDFQRDKEAAERAIKRDEAKAKKAQQLKRMNGKIASSTNNKNPLASSSTSVGDGGMVEDIMQSVRDGDAFKQRRRLKGTKENTDDSSSITTISEQSENSNTSSITITTPSGIELDITPSKSGSRREKKTSKSSDKDKEKEKEKEKQCESTESEDINKKDINVAAKALTIVMRSKQTMHSRIDTFNFDA
What is the function of this protein?
Formins play an important role in the nucleation of actin and the formation of linear actin filaments.
What are the official names of this protein?
Formin-F, Diaphanous-related formin dia1.
What is the protein family that this protein belongs to?
Belongs to the formin homology family. Diaphanous subfamily.