PharMolix/UniProtQA huggingface dataset:
Protein: RF1_ACIBY
Sequence: MKASLRLRLDQLCDRHEELTALLADAEVISDNKRFRKLSREHSDLTEITEVWGKYRQAEEDIETAEMMKSDPDFKDMAEEEIQANKVLLEELESQLNILMIPKDPNDSNAAYLEIRAGTGGDEAAIFSGDLFRMYSKYAESQGWRIEVLSENEGEHGGFKEVICRVDGDGVYGRLKFESGAHRVQRVPATESQGRVHTSACTVAILPEIDVDTNVEINPADLRIDTYRASGAGGQHINKTDSAVRITHIPTGTVVECQEERSQHKNKAKAMALLVSRLENAKRAAADAATSEMRRDLVGSGDRSERIRTYNYPQGRMTDHRINLTLYKLDAIMEGDLTELLDSLHREYQADQLAMLAQENGG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_KORVE
Sequence: MSRTKDPAKQAEDLREKLRYHEHRYYVLDDPEISDADYDVMMNELKALEAKHPELLTPDSPTQRVGGKPREGFVKVAHSAPMLSLDNAYNEEELRDWARRVEELSGKAEIEYECELKLDGLSMALRYQDARFVLAVTRGDGSIGEDVTLNLRTVKSVPLGVSSATLKKTHMLGDFEVRGEVIFPTKSFEKMNEDREKQGLAKFANPRNAAAGAVRVLEPNITAQRRLDFYAYFLLVDGRVHIDRQSEALDTLEKLGFKVNSNRAVFKSIDDVLKFIHKKEEDREKLPYEIDGVVIKVNSTALWQRLGFTGKAPRWAIAYKYAARAAVTQVEDILVQVGRTGKLTPVAALKPVPIGGTTVSRATLHNMDEIDRLGLLIGDWVQVERGGDVIPKVVKVIDDKDHPRGKKKFKMPERCPECGGHVVRTEGEADHRCVNANCPAKLRESILHFASRGVMNIEGMGDSLVNQLVDRGLVKNVADIYELDEEKLLSLERMGKKSAQNILDEIKGTKKLPLERVIYGLGIRMVGERTAQFLAEHFGSLDGVMKATEEELLEVEEVGPRIAQSIHEFFAEPSNRELVKRLEAAGLQFKGVKKERGTALAGQTFVLTGSLPTYSRDEAKKLIEDAGGKVSGSVSKKTNYVVAGEEAGSKLDKARDLGVAVIDEDALKKLLGK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RSMG_CORDI
Sequence: MWGYTVEKGWFHVKHEEIESIASHVFGGNVDKAYAYHELLATDGSTRGFIGPREVPKLWSRHLLNCAVIGEAMDENIRVADIGSGAGLPGIPLAIARPDLTITLIEPLLKRSVFLGEVKEKLELDNVTVIRGRAEEKAVREQLGLVDVATSRAVAPLGKLAGWSLPLVRLGGKMIAMKGSSVHEELERDEKMIWKAGGGKVKIFSVGEVLEEPTTLISIRKVR
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH4_XANOP
Sequence: MSATLPDVAVTEAFTLSAPLRWVGMQDIAIPVHLDAASGSGLAARASVQVDLPRAELKGIHMSRLYRLLDLHLQRPLSPAMLPQLLQALIESHADCASRAARLTLSFALMLRMPALRSEGLSGWRAYPVRIAAQCRAGRTTIQLQVEVLYASTCPCSAALSRQLLSDAFVQQHAWCDALPLQDVAQWLQDHGSYATPHSQRSVAQVCVDLPADTQGFAIQELIGLCEQALATPVQAAVRRPDEQAFARLNGANLMYVEDAARRLRKQLAEHYATFHVAVRHLESLHAHDAVAETGSDDETFFPAAL
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: SPO13_YEAST
Sequence: MAPRKRFRLLELGSPTHSKRKVQKPLQEKTPNLRVSPLAFKIGKEIKNKEIRKTKKTESENIFNSKHVDLRLESPHPGLNFVSDAQQYSKAGDVRYLKNKSSNTLKNERQTIERPSFDNSLRFEDIEQPPKSTSTPVLSQSSQINVEREAPMFPVPYYIAPSPMYNFSPYQNFVGNPTFLTPSHNPNLNYAIPIQRPELLYPNVNVYDSPLFKKTRLPHQTKSLDKEKNYQYLPIYPVSISNNGDFVGQETPRAAPKLSKKRLSNTLDVNCSDYESSGQNATYNDSESSLN
What is the function of this protein?
Required for meiosis I segmentation (PubMed:2123556).  Probably acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (PubMed:25533956).
What are the official names of this protein?
Meiosis-specific protein SPO13, Sporulation-specific protein 13.
What are the subcellular locations of this protein?
Nucleus.
Protein: SMG_STRMK
Sequence: MKESILDVLLYLFEHYFSEDADLIRDRDSLQNGLIQAGFSPTEINKAFDWLDALAAQRPSVAQARVDGPVRVYHGPELDKLDVECRGFLLYLEQHGILDADQRELVLDRAMALDQDELDLDDLKWVVLMVLFNQPGSEAAYAWMETQMFMDEPEPLH
What are the official names of this protein?
Protein Smg homolog.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: DCTA_AZOC5
Sequence: MAPVIPAASAPHKPRKFYQHLYVQVLAAIAIGILLGHFYPDLGTQMKPLGDAFIKLVKMVIAPVIFLTVVTGIAGMRDLAKVGRVAGKAMIYFLTFSTLALIIGLIIANVVQPGAGMHIAPASLDPKAVASYAAKAHDASIIGFLMNIIPDTPISALGSGDILQVLFFSVLFGIALAGVGDRGEPVMNVLVSASQAMFRLVHILMKAAPIGAFGAMAFTIGRYGIGSVANLAFLILTFYITSFLFVVVVLGLVARYNGFSIFALLRYIKEELLLVLGTSSSEAALPSLIEKMERAGCRKSVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATDIHLSLGDQILLLLVAMLSSKGAAGITGAGFITLAATLSVVPTVPLAGMALILGIDRFMSECRAITNFIGNAVATIVVARWEGELDKDKLAAALSGRISVEDDDLPIEATSPAQ
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SL9A3_HUMAN
Sequence: MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKRLESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGETVVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM
What is the function of this protein?
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions.  Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773).  Plays an important role in signal transduction.
What are the official names of this protein?
Sodium/hydrogen exchanger 3, Na(+)/H(+) exchanger 3, NHE-3, Solute carrier family 9 member 3.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity).
Protein: RTCB_MYCBO
Sequence: MQVVNVATLPGIVRASYAMPDVHWGYGFPIGGVAATDVDNDGVVSPGGVGFDISCGVRLLVGEGLDREELQPRLPAVMDRLDRAIPRGVGTAGVWRLPDRNTLQEVLTGGARFAVEQGHGVALDLERCEDGGVMTGADAAKISDRALQRGLGQIGSLGSGNHFLEVQAVDRVYDPVAAAPMGLAEGTVCVMIHTGSRGLGHQICTDHVRQMEQAMGRYGIAVPDRQLACVPVHSPDGQAYLAAMAAAANYGRANRQLLTEATRRVFADATGTPLDLLYDVSHNLAKIETHPIDGQLRSVCVHRKGATRSLPPHHHELPAELAAVGQPVLIPGTMGTASYVLAGVTGNPAFFSTAHGAGRVLSRHQAARHTSGEAIRASLAKRGIIVRGTSRRGIAEEKPEAYKDVDEVIEASHQSGLARKVARLVPLGCVKG
What is the function of this protein?
GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair.  Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.
What are the official names of this protein?
RNA-splicing ligase RtcB, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
Protein: RS15_DESAL
Sequence: MALTAKTKQELIEEFKTHDSDTGSPEVQVALLTNRITYLTEHFKTHKKDHHSRRGLLKLVGQRRRLLNYLKNKDVQRYRTLIEALGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RL19_ECOL5
Sequence: MSNIIKQLEQEQMKQDVPSFRPGDTVEVKVWVVEGSKKRLQAFEGVVIAIRNRGLHSAFTVRKISNGEGVERVFQTHSPVVDSISVKRRGAVRKAKLYYLRERTGKAARIKERLN
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: TSAD_BRADU
Sequence: MLVLGIETTCDETAAAVIERAPDGIGKILSNIVRSQVDEHAPFGGVVPEIAARAHVDLLDGIIDRAMREAGIGFAQLNGVAAAAGPGLIGGVIVGLTTAKAIALVHDTPLVAVNHLEAHALTPRLTDGIEFPYCLFLASGGHTQIVAVTGVGQYVRLGTTVDDAIGEAFDKVAKMLGLPYPGGPQVERAAAGGDAARFAFPRPMQGRPDANFSLSGLKTAVRNEASRIAEITPQDISDLCASFQAAVLEATADRLNVGLRLFREQFGAPRALVAAGGVAANQAIRGALHDVARQAKTQLIMPPPALCTDNGAMIAWAGAERLALGMTDTMEAQPRARWLLDANATAPAGYGKTRAGF
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXR_DESVV
Sequence: MIRYISAMPSPEWEHETPRTLALLGSTGSIGTSALRVVEAHPHRFRVVALAGARNVEKLAAQAARWRPEHLGVLDAAGAAKLRDLLPAGYAPHIHIGPEGYATMATLPEAGTVLSAQVGAAGLRATEAAARHGKVICLANKESLVLAGDIIRRHCAGSGAVILPVDSEHNAIFQALQGHDPASVRRIILTASGGPFRGRSREDLAAVSCRDALAHPNWDMGAKITIDSATLMNKGLEVIEACHLYGVGIDDVGVVVHPQSIVHSLVEYEDGSQIAHLGTPDMRIAIAYCLTWPGVVDAGVPRLDLVKAGSLTFEEPDLHSFPCLELARRAYREGRGMPVVLNAANEVAVSLFLSDRIRFLDIPDIIARALDMHDGTTPHDIEGIEALDEATRRTVYERAGHSNTDGMA
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: PB2_I02A2
Sequence: LRDLMSQSRTREILTKTTVDHVAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIMGMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWNRNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKIAPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMIGILPDMTPSTEMSLRGVRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQDPTMLYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: ATP6_HUMAN
Sequence: MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLITTQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNLAMAIPLWAGTVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRLTANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLVSLYLHDNT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PSPB_HYDTT
Sequence: MKRLYLVRHAQSEYNEKGIFQGRLDSDLTPLGFVQARLLAREFLKKKVDIIYSSPQRRAYKTALTISDMLGTQLVVDERLREMSFGEYEGKHFWSMLEAHKDVFLNWLSNPVKHPLPTQESMEEFEKRVRSFLEDVKSSHYQNMLIVAHGGTLHAIVCLLTGIGLENLWNIHMDNAGITEIHMEGEKSTLVYLNKLCHTRQLT
What is the function of this protein?
Part of a complex that catalyzes the dephosphorylation of L-phosphoserine to serine and inorganic phosphate.  Is poorly or not active toward D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para-nitrophenylphosphate, and fructose-6-phosphate.  Does not display phosphoglycerate mutase activity.
What are the official names of this protein?
Putative phosphoserine phosphatase 2, PSP 2, PSPase 2, Metal-independent phosphoserine phosphatase 2, iPSP2, O-phosphoserine phosphohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the histidine phosphatase superfamily. Metal-independent phosphoserine phosphatase family.
Protein: INSRR_CAVPO
Sequence: MARPKLWPWGILLLVSLLSAGFNLDTMNVCPSLDIRSEVAELRRLENCSVVEGHLQILLMFTATGEDFRSLSFPHLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGAHLFLGYALVIFEMPHLRDVGLPALGAVLHGSVRVEKNQELCHLSTIDWGLLQPTPSTNYIVGNKLGEECADVCPGTLGAAGEPCARTTFNGHTDYRCWTSSHCQRVCPCPQGLACTISGECCHTECLGGCSQPEDPRACVACRHFYYQSACHRACPLGTYEHESWRCVTAESCANLRSVPGRASTFGIHQGKCLAQCPPGFTRNGSSIFCHKCEGLCPKECKVGTKTIDSVQAAQDLVGCTHVEGSLILNLRRGYNLEPELQRSLGLVETITGFLKIKHSFALVSLSFFKNLKLIRGDTMVDGNYTLYVLDNQNLQQLGPWVSAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRAACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGSQSWNLLDVELPLSRTQEPGVILAPLKPWTQYAVFVRAITLTTAEDSPHQGAQSPIVYLWTLPAAPTVPQDVISSSNSSSHLLVRWKPPTQRNGNITYYLVLWQRLAEDGDLYLNDYCHRGLRLPTSNHDPRFDREDGDLEAELELGCCPCQHAPPGQVLPALEAQEASFQKKFENFLHNAITIPKPPWKVTSIHRNLQRDAGRHRRAIGSPRPGGNSSDFEIQEDKVPRERAVLGGLRHFTEYRIDIHACNHAAHIVGCSAATFVFARTMPRREADDIPGKLSWEAASKSSVLLRWFEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKVGGVQLALLPPGNYSARVRATSLAGNGSWTDSVAFYIPGPEEEDSGGLHILLTVTPAGLMLLIILAALGFFYSRKRNGTLYTSVNPEYLSASDMYIPDEWEVPREQISIIRELGQGSFGMVYEGVAKGLEAGEESTPVALKTVNELASPRERIEFLKEASVMKAFQCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGIPRPALGDMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEDCPHQLQELMSSCWQQNPRLRPTFTQILNSIQKELRPSFRLLSFYHSPECQGGCGLQPTTDAESSSPPTSKGASDCSLQNGGPEH
What is the function of this protein?
Receptor with tyrosine-protein kinase activity.  Functions as a pH sensing receptor which is activated by increased extracellular pH.  Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB (By similarity).
What are the official names of this protein?
Insulin receptor-related protein, IRR, IR-related receptor.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ZN791_HUMAN
Sequence: MDSVAFEDVSVSFSQEEWALLAPSQKKLYRDVMQETFKNLASIGEKWEDPNVEDQHKNQGRNLRSHTGERLCEGKEGSQCAENFSPNLSVTKKTAGVKPYECTICGKAFMRLSSLTRHMRSHTGYELFEKPYKCKECEKAFSYLKSFQRHERSHTGEKPYKCKQCGKTFIYHQPFQRHERTHIGEKPYECKQCGKALSCSSSLRVHERIHTGEKPYECKQCGKAFSCSSSIRVHERTHTGEKPYACKECGKAFISHTSVLTHMITHNGDRPYKCKECGKAFIFPSFLRVHERIHTGEKPYKCKQCGKAFRCSTSIQIHERIHTGEKPYKCKECGKSFSARPAFRVHVRVHTGEKPYKCKECGKAFSRISYFRIHERTHTGEKPYECKKCGKTFNYPLDLKIHKRNHTGEKPYECKECAKTFISLENFRRHMITHTGDGPYKCRDCGKVFIFPSALRTHERTHTGEKPYECKQCGKAFSCSSYIRIHKRTHTGEKPYECKECGKAFIYPTSFQGHMRMHTGEKPYKCKECGKAFSLHSSFQRHTRIHNYEKPLECKQCGKAFSVSTSLKKHMRMHNR
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 791.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRBC1_HUMAN
Sequence: DLNKVFPPEVAVFEPSEAEISHTQKATLVCLATGFFPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSVSYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDF
What is the function of this protein?
Constant region of T cell receptor (TR) beta chain (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:9382891, PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta constant 1.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RLUD_BORBU
Sequence: MIRVKREFTVKENALRLDLYLSGNFEVFTRSQIKRRNVEAFKKSNGKFLKIKLSKPVFKDDEILIEFDEESSQIDCLRPSNIPIAIIYEDSNVIVLNKPQGILSHPGISHWDDTVVNFLLYHIKSLKINFNEEKIRPGIVHRLDKDTSGVLICAKNISTLRFLAQQFKDKRTNKVYIAIVKGNFNSFFGSIESFIDRDKHNRKKFSVSKDRGKKALTEYRLLLNFGEYSLLALKPKTGRTHQLRVHMKYLNFPILGDEVYGRVDGSLKKITLMLHSYKLEIDVGKNSFKKFISEFPKRFVIFLSNFYKSDELNLIIDNLVLFLRDF
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase D, 23S rRNA pseudouridine(1911/1915/1917) synthase, rRNA pseudouridylate synthase D, rRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: TATC6_HYPAT
Sequence: MGQPTTTSLFMRDVMFHRMTGTSQAVNDVATLSGERREIIRRALNKKILVPNILELMPAWPSEFQPNIDEVNVEIDEWLKTVNVAKEKKLKHRARGNYTLLAGIYYPHCRKEKMLALSQFLYWIFFWDDEIDTGGELTEDREGTILCCAETNKCINDCLGPEPNYTPPPGSRGTVEMLYPILRDLRAGLSPVSTMRLKQELHDYVNGVKNQQKVRQEDHLPNPWDHFQMRVDDVGVIPSITQNEYAMDFTLPDWIRRHEAMEEIVLQCTKLTILLNEILSLQKEFRVSQLENLCLLFMNTYDMSIEQSIHKVLGLLKDHYKICIEAEARLPWSTTDEKLNNNIREYIRGCQRLATGTACWSYNCERYFKLSQLNDQQELLLDLSRT
What is the function of this protein?
Terpene cyclase that is able to convert FPP into a mixture of sesquiterpene hydrocarbons and alcohols (PubMed:31418991).  The main product is trichobrasilenol (PubMed:31418991).  Additionally, side products include alpha-humulene, caryophyllene, 2-epi-caryophyllene, african-3-ene, african-1-ene, isoafricanol and pristinol (PubMed:31418991).  Does not accept GPP, GGPP, and GFPP as substrates (PubMed:31418991).
What are the official names of this protein?
Terpene cyclase 6, Sesquiterpene synthase 6.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: YFHE_BACSU
Sequence: MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK
What are the official names of this protein?
Uncharacterized protein YfhE.
Protein: ATPB_PRIM1
Sequence: MTKGRVTQIMGPVVDVKFDNGHLPAIYNALKISHKPSSASEVAIELTLEVAIHLGDNTVRTVAMSSTDGLVRGLEVEDTGAAISVPVGDVTLGRVFNVLGEKIDLDAPIDAGARRDPIHRQAPKFENLSTQAEILETGIKVVDLLAPYIKGGKIGLFGGAGVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLYHEMTDSGVIKKTAMVFGQMNEPPGARQRVALTGLTMAEYFRDEQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTSVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERKLSEMGIYPAVDPLASTSRALSPEIVGEEHYAIARQVQQTLQRYKELQDIIAILGMDELSDEDKLVVQRARRVQFFLSQNFHVAEQFTGQKGSYVPVKETVKGFKEILEGKYDHLPEDAFRLVGRIEEVIENAKRMGVEV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DPHB_SULIA
Sequence: MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEADRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTANEALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIPGNLHYMEADAIKWMLMS
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.