PharMolix/UniProtQA huggingface dataset:
Protein: ISPE_AQUAE
Sequence: MIKVLSPAKINLGLWVLGRLPSGYHEILTLYQEIPFYDEIYIREGVLRVETNIGIPQEENLVYKGLREFERITGIEINYSIFIQKNIPPGAGLGGGSSNLAVVLKKVNELLGSPLSEEELRELVGSISADAPFFLLGKSAIGRGKGEVLEPVETEISGKITLVIPQVSSSTGRVYSSLREEHFVTPEYAEEKIQRIISGEVEEIENVLGDIARELYPEINEVYRFVEYLGFKPFVSGSGSTVYFFGGASEELKKAAKMRGWKVVELEL
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: YPFB_BACSU
Sequence: MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGVDKMEENNRIETFKH
What are the official names of this protein?
Uncharacterized protein YpfB.
Protein: Y2130_DICDI
Sequence: MGSGESKNFGNIAQQSRLDHADLTVLLKQFNAISKNGEIKKDDLKKIIEKKYGSDSSLTAILYNLFDRDGDKTINFTEFALAYGFLVNKTLDDVVDTSFHCMDLNGDGNISKGELRAVVMMNKKMEKYIQNDKKVPLDKLTLLPIEVSKINQEADDLFLQLDVNKDGGVSKQEFIQLASSSPELKKKLTSYLVRDEALDFFGTTK
What are the official names of this protein?
Recoverin family protein DDB_G0272130.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
Protein: MNMA_PETMO
Sequence: MSNKKVLMLMSGGVDSSVAAYLLKEQNYHVIGLHFKTVSDVVFSLIPEKKKVCCSPSDTQDALKIADKLDLDDFQIVDIKKEFKEKIIDYFIKTYKEGKTPNPCMLCNRFFKFGKALEIAHSYGADWVSSGHYLIKEYSNKYSTYIIKKGVDQYKDQSYFLSYIDKNTLPKLHFPLGNMYKVEIRDIANKIGLSVANKPDSQELCFIPDNDYRRFLKENGVTTEEGKVYDLEGNEIGTHTGYMNYTIGQRSGISYYKNANVKLHVYKIFPQKNVLIVAPTEEMYSKELIVQNVNFFVDFKEIEGFCRVRKKSEEKPAVVKKIADHTLKVSFKEPIFAVTPGQFATIYDESGVVLASGVINIKEMGEV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBHG_ECO7I
Sequence: MMKKPVVIGLAVVVLAAVVAGGYWWYQSRQDNGLTLYGNVDIRTVNLSFRVGGRVESLAVDEGDAIKAGQVLGELDHKPYEIALMQAKAGVSVAQAQYDLMLAGYRDEEIAQAAAAVKQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQATLKSAQDKLRQYRSGNREQDIAQAKASLEQAQAQLAQAELNLQDSTLIAPSDGTLLTRAVEPGTVLNEGGTVFTVSLTRPVWVRAYVDERNLDQAQPGRKVLLYTDGRPDKPYHGQIGFVSPTAEFTPKTVETPDLRTDLVYRLRIVVTDADDALRQGMPVTVQFGDEAGHE
What are the official names of this protein?
UPF0194 membrane protein YbhG.
What is the protein family that this protein belongs to?
Belongs to the UPF0194 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HIS1_MYCBP
Sequence: MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEFFFLRPKDIAIYVGSGELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGRNWTTADLAGMRIATAYPNLVRKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGRTLSQHDLVAFGEPLCDSEAVLIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYDCPRSALKKATAITPGLESPTIAPLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILASDIRFCRF
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRYAA_MOUSE
Sequence: MDVTIQHPWFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISELMTHMWFVMHQPHAGNPKNNPVKVRSDRDKFVIFLDVKHFSPEDLTVKVLEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVQSGLDAGHSERAIPVSREEKPSSAPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.  Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein: LPXK_HAMD5
Sequence: MIDRIWFGHSRLYLLLLPFSWLYGLITWLIRLSYRSGLRVAWRSPIPIVVVGNLTVGGNGKTPIVIWLVEQLKKRGLQVGVVSRGYSGKSGKYPLILSHHTQPEEAGDEPVVIFQRTGVPVAVAPKRKEAIRALLKKHPLDLLIADDGLQHYALKRDFELVVIDGIRRFGNACLLPAGPMRENITRLHSVDAIIINGGEAQKEEILMQLRPSQAVNLVTGEKKPVEELISVIAMAGIGHPDRFFMMLAQLGVNIIKTQIFSDHQHYTLSTLLPLAKKTQSLCMTEKDAVKCKAFAQPNWWYLPVSADFPFVQSQKLLASIEALCHRIC
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: LIVB6_BRUAB
Sequence: MKKIALTALAVFSLAASAAYADVVKVGVIGPFSGPFALQGKNFKAGIDAYMAEHGNKVGDDTVEVVYRDVPQADPAQSKALAQELVVKEGVQYLAGFYFTPDAMAVTPILKQGNVPMVVMNAATSSIVTKSPYVVRTSFTTWQTSTPIARVALDKGVKKVISVVSDYGPGVDAENAFKAAFTDAGGEVVEAIRMPLATNDFSPIMQRIKDSGAQGVFAFLPSGPTTFGFMKAYVDNGLKSSGIQLFAPGDLTQESDLPALGENALGVLTTFHYAVSHDSPENRKFVEEARKAIGNPAELSFPSVGAYDGMHVIYKMIEATGGKKDAAKAVEAVKGMEWVSPRGPVSIDPESRHITQNIYLREVAKADDGTYYNKEIQTFEKQGDPGLKAQ
What is the function of this protein?
Component of an amino-acid transport system.
What are the official names of this protein?
Leu/Ile/Val-binding protein homolog 6.
What is the protein family that this protein belongs to?
Belongs to the leucine-binding protein family.
Protein: FLGI_SALAR
Sequence: MYVFKALAGIVLALVATLAHAERIRDLTSVQGVRENSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTASYPPFARQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAIIERELPSQFGAGNTINLQLNDEDFTMAQQITDAINRARGYGSATALDARTVQVRVPSGNSSQVRFLADIQNMEVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQLNVNQPNTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSANLNSVVRALNALGATPMDLMSILQSMQSAGCLRAKLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: QUEC_METST
Sequence: MKPKAITVLSGGLDSTVATSIYANDYDITAITFNYGQQSIKQELKHAKMICEKLDMKHIVIDLPWLKEISNSSLTTDKSIPQPSDNDLDDYDKSIETAKSVWVPARNTVFCSIALSYAESIQAKIIIVGWDYEEAVTFPDNSKEYLKSFNETIKYGSFDDIEIKAPLIDMTKEDIVKKGHEVNAPMNISYSCYVGCDTHCGVCESCKRRKRAFTRANVTDYTEYEK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, Archaeosine biosynthesis protein QueC, PreQ(0) synthase.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: OSTA_XENTR
Sequence: MDPEQNDTKPPFNPICATRQAPYSHEILENLDITGILLFAILTFMTLVSLLVFLEEAYYMYRKIPNPKNSIIIWINAGAMMIATTSCFGMWIPRSTMFTDFTASVFLAVLIHKFQLMLVNECGGRREFLSTFGDTKLKISTGPFCCCCLCLPHKDINRKTLFILKLGTFQFAFLRPVLMFLAVVLWTNGTYMIGNSSAEKATIWINIGVGITTITALWAVGIMFNLVKDNLKEKNIIGKFAVYQFTVILSQLQTSIINILGTTGVISCVPPLPGPSRASYMNQQLLIMEMFLVTVICRVLYRRRYDDKNLLENQETNDNLRNSMMHLNGKALEDGPQSV
What is the function of this protein?
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for the translocation of bile acids (such as taurocholate), steroids (such as estrone sulfate), and eicosanoids (such as prostaglandin E2).
What are the official names of this protein?
Organic solute transporter subunit alpha, OST-alpha, Solute carrier family 51 subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the OST-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NUSB_MACCJ
Sequence: MSRTESREHAIQILFQIENEAHEISVEDATRFIVEPPNRDVFADELVHGVISKQNELDDKITPHLKSWALERLNKIDRIILRLSAFELLYTDAPEKVIVNEAVNLAKKFSDDESYKFINGVLSEIIKNKA
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RNC_PSEAE
Sequence: MSNSLDRLERKLGYTFKDRDLMVLALTHRSYAGRNNERLEFLGDAILNFVIGEALFHHFPQAREGQLSRLRARLVKGETLALLARGFEVGDYLRLGSGELKSGGFRRESILADAMEALIGAIYLDTGMDSARERIIAWLGPQLRELTPVDTNKDPKTRLQEFLQSRGCDLPRYEVVDIQGEPHCRTFFVDCEVALLSDKTHGHGGSRRIAEQVAAAAALVALGVENGHD
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACB2_STRP6
Sequence: MKIAVGCDHIVTYEKIAVVDYLKSQGHKVIDCGTYDNVRTHYPIFGKKVGEAVASGKAELGVVICGTGVGITNAVNKVPGIRAALVRDMTSAIYSKEELNANVIGFGGKIIGGLLMNDIIDAFLAAEYKPTEENKKWIEKMDSLQHTNQDQNNPHFFDEFLEKWDRGEYHD
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacB 2.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: MUTS_GEOSL
Sequence: MSELTPMMRQYLEIKADHPDAILFFRLGDFYEMFLDDAVKASRILDITLTSRNKGGDGADIPLCGVPFHSAAPYIAKLVEAGEKVAICEQVEDPKSVKGIVKREVVKVVTPGLVIDAESLSPKENNYLLSLFPGPDRWGVAYLDLSTGDFRVTETDSADAAWAEVACVNPREILMPLSFRDGGAGSERPDLAAGRMLSYVDEWVYDAEYAERMVRNHFGVASAEAAGCGSMDCGLRAVAAVLHYLQQTQKGDVRHISYLQAYRTQEFLVLDESSRRNLELNATIGDGKRRGSLLGLLDRTVTAMGGRKLKQWINYPLVSIEKINERLDAVEELVADAEFRQGVRAALDGVYDLERLNGRISLASASAKDLVALRASLVRLPSLIALLTPAASTLLARLRDGIDLLADVEELIGRGIVPDPPFVLREGGIIAQGYHSELDELRSISREGKGFIARLEAQEKARTGISSLKVRYNKVFGYYIEVTKSNLSAIPDDYIRRQTLANAERFITPELKEYEEKVLGAEDRIVELEYALFQDIRQRVAAQGERIARTADRLATLDVLAALADVAHDHRYVRPTVDEGDAIVVTGGRHPVVEALNRSERFVANDVQLDNGENQLVIITGPNMAGKSTFMRQVALIVLMAQTGSFVPADEASIGVVDRIFTRVGASDNLARGQSTFMVEMMETAAILRNATPRSLVVLDEIGRGTSTFDGVSIAWAVAEYLHDTERCAAKTLFATHYHELTELAVTRNRVKNCNVAVKEWNDQVIFLRKIVEGGASHSYGIQVARLAGLPQEVIERAKEILHNLEKGEYAEGGIPRIARGKRAGAPKPSPQLSLFDQGDDLLRRRIAGLNIAALTPLEALNILDELKRMV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: MCI_MYTUN
Sequence: FDESFGFQGPSTYEKTPLGEPA
What is the function of this protein?
Inhibits chymotrypsin stoichiometrically.  Also inhibits porcine pancreatic elastase and trypsin.
What are the official names of this protein?
Chymotrypsin inhibitor, MCI.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: RS15_MARMS
Sequence: MALSAESKAALVKEFQVAEGDTGSPEVQVALLTKNIEGLQGHFKAHIHDHHSRRGLIRMVNQRRKLLDYLKRKDAARYTSLIKKLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: IBP1_SCHPO
Sequence: MSTLSYVSPDALKGWLMESPNEISIIDVRDYDYEGERIPGSVRIPSDTFLASVDQHVDDLMKKRSLIVHCTYSQVRGPKAARVLSEILRNRITESKEKLSLSQKEKLFQNLPTVYILHGGFSAWKRRYGGQQGLIEYD
What is the function of this protein?
May play a role in DNA replication checkpoint via regulation of hsk1 or may act downstream of hsk1 in an S phase regulatory pathway.
What are the official names of this protein?
Dual specificity phosphatase ibp1, Cdc25-like phosphatase ibp1, Itsy bitsy phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the MPI phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PLAP_MOUSE
Sequence: MASGASRYRLSCSLPGHELDVRGLVCCLYPPGAFVSVSRDRTTRLWAPDSPNRGFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKDTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWKAGRCERTFLGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYFGHTNYIYSISVFPNSKDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLENGDIVVGASDGIIRVFTESEERTASAEEIKAFERELSQATIDSKTGDLGDINAEQLPGREHLSEPGTREGQTRLIRDGERVEAYQWSVSDGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSDDPWLVAYNFLQKNDLNPMFLDQVAKFIIDNTKGQTLGLGNTSFSDPFTGGGRYVPGTSGPSNTVQTADPFTGAGRYMPGSAGMDTTMTGVDPFTGNSAYRSAASKTVNIYFPKKEALTFDQANPTQILGKLKELNGTAPEEKKLTEDDLVLLEKILSLICNNSSEKPTAQQLQILWKAINWPEDIVFPALDILRLSIKHPNVNENFCNEKGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLTLNYSVCFHKDHNIEGKAQCLSVISTILEVVQDLEATFRLLVALGTLISDDSNAIQLAKSLGVDSQIKKYVSVSEPAKVSECCRLVLHLL
What is the function of this protein?
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity).  Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (PubMed:28413018).  May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity).  Plays a role in cerebellar Purkinje cell development (PubMed:28413018).  Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:28007986).
What are the official names of this protein?
Phospholipase A-2-activating protein, PLA2P, PLAP.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PLAP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Synapse. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains.
Protein: JEM1_YEAST
Sequence: MILISGYCLLVYSVILPVLISASKLCDLAELQRLNKNLKVDTESLPKYQWIAGQLEQNCMTADPASENMSDVIQLANQIYYKIGLIQLSNDQHLRAINTFEKIVFNETYKGSFGKLAEKRLQELYVDFGMWDKVHQKDDQYAKYLSLNETIRNKISSKDVSVEEDISELLRITPYDVNVLSTHIDVLFHKLAEEIDVSLAAAIILDYETILDKHLASLSIDTRLSIHYVISVLQTFVLNSDASFNIRKCLSIDMDYDKCKKLSLTISKLNKVNPSKRQILDPATYAFENKKFRSWDRIIEFYLKDKKPFITPMKILNKDTNFKNNYFFLEEIIKQLIEDVQLSRPLAKNLFEDPPITDGFVKPKSYYHTDYLVYIDSILCQASSMSPDVKRAKLAAPFCKKSLRHSLTLETWKHYQDAKSEQKPLPETVLSDVWNSNPHLLMYMVNSILNKSRSKPHSQFKKQLYDQINKFFQDNGLSESTNPYVMKNFRLLQKQLQTYKEHKHRNFNQQYFQQQQQQQQHQRHQAPPAAPNYDPKKDYYKILGVSPSASSKEIRKAYLNLTKKYHPDKIKANHNDKQESIHETMSQINEAYETLSDDDKRKEYDLSRSNPRRNTFPQGPRQNNMFKNPGSGFPFGNGFKMNFGL
What is the function of this protein?
Acts as a DnaJ-like chaperone required for nuclear membrane fusion during mating.
What are the official names of this protein?
DnaJ-like chaperone JEM1, DnaJ-like protein of the ER membrane 1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Nucleus membrane.
Protein: RNP3_HALLT
Sequence: MYEAVHAHPDGDATVARHAATAERYGYEGIVVRTREALDPASKSSEHADEATALRDEYGIDVVDAVEIDADNATSASGAVGNYRSDRTVVCVVGGDDGLNRFAVEEPRVDVLVRPMGGGDFNHVLAKAARDNGVHVEFDLGPLFRATGGKRVRALADLRKLREIVTYYDTPHVVSANPRSHLDLRAPREVVAAAEAVGFDAEWVREGLRAWGEIATRNRERRSEAFIEPGVRRGRYEEDG
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 3, RNase P component 3, Rpp30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATB_PASMU
Sequence: MFDIGFSELFLILVIGLLVLGPKRLPVAIRTVMGWVATIRGLASNVQNELKQELKLQELQESIKKAEELNFQQLSPELSKTVEELKASAEKMRTALEQKAAATNTTLEEQIKEIKNATESTSQTLTEQLTPSEQVTEATTDDVLSPAEQAELAEENDEMVYIQQYYPDDDDEPVFASKVKPQTEEIQDKKA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RUTA_ECOS5
Sequence: MQDAAPRLTFTLRDEERLMMKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGSGKSDFKGDFFTMDDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVANVPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHLPALTQEVA
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
Protein: KTHY_PARPJ
Sequence: MARGKFITFEGIDGAGKTTHLSWFRERLEQKVASTGRSVVMTREPGGTPLGEQIREIVLHQKMDLETEALLMFALRRQHLAEVIEPALARGDWVLSDRFTDATFAYQGGGRGLPRDKLETLERWVQGGFQPDLTVLFDLAPEIANERRSAARDPDRFESESVAFFNRTRAEYLRRAEEAPYRFAIIDSAQSIVQIQRKLEELIAIL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: CH033_MOUSE
Sequence: MAEPGRPAREAPAASSRKTHRAPRRPRPSRSASGASEPPLRSSVQPACDSAAGTHPVGNTVAMKQKKKKTPNRVSGTNGSEKPSEKPAPDEAPPSAEAQAEQLARELAWCVEQLELGLKTQRPTPKQKEQAVGAIRTLRSEKTPLPRKRQLMRSLFGDYRAQMDAEWREALRALKAATHSAQVQLVSEATRKKSGRVCRPRPAERAKTTPDLTSEEFRFNFF
What are the official names of this protein?
UPF0488 protein C8orf33 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0488 family.
Protein: ILVB2_MAIZE
Sequence: MATAATAAAALTGATTATPKSRRRAHHLATRRALAAPIRCSALSRATPTAPPATPLRPWGPNEPRKGSDILVEALERCGVRDVFAYPGGASMEIHQALTRSPVIANHLFRHEQGEAFAASAYARSSGRVGVCIATSGPGATNLVSALADALLDSVPMVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVLDVDDIPRVVQEAFFLASSGRPGPVLVDIPKDIQQQMAVPAWDTPMSLPGYIARLPKPPATEFLEQVLRLVGESRRPVLYVGGGCAASGEELCRFVELTGIPVTTTLMGLGNFPSDDPLSLRMLGMHGTVYANYAVDKADLLLAFGVRFDDRVTGKIEAFAGRAKIVHIDIDPAEIGKNKQPHVSICADVKLALQGMNTLLEGSTSKKSFDFGSWHDELDQQKREFPLGYKIFNEEIQPQYAIQVLDELTKGEAIIATGVGQHQMWAAQYYTYKRPRQWLSSAGLGAMGFGLPAAAGAAVANPGVTVVDIDGDGSFLMNIQELAMIRIENLPVKVFVLNNQHLGMVVQWEDRFYKANRAHTFLGNPENESEIYPDFVAIAKGFNIPAVRVTKKSEVHAAIKKMLEAPGPYLLDIIVPHQEHVLPMIPSGGAFKDMILDGDGRTVY
What are the official names of this protein?
Acetolactate synthase 2, chloroplastic, Acetohydroxy-acid synthase 2.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PTER_PONAB
Sequence: MSSLSGKVQTVLGLVEPSKLGRTLTHEHLAMTFDCCYCPPPPCQEAISKEPIVMKNLYWIQKNAYSHKENLQLNQETEAIKEELLYFKANGGGALVENTTTGISRDTQTLKRLAEETGVHIISGAGFYVDATHSSETRAMSVEQLTDVLMNGILHGADGTSIKCGVIGEIGCSWPLTESERKVLQATAHAQAQLGCPVIIHPGRSSRAPFQIIRILQEAGADISKTVMSHLDRTILDKKELLEFAQLGCYSEYDLFGTELLHYQLGPDIDMPDDNKRIRRVRLLVEEGYEDRILVAHDIHTKTRLMKYGGHGYSHILTNVVPKMLLRGITENVLDKILIENPKQWLTFK
What are the official names of this protein?
Phosphotriesterase-related protein, Parathion hydrolase-related protein.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
Protein: ASSY_PARPJ
Sequence: MSDIKKVVLAYSGGLDTSVILKWLQDNYDAEVVTFTADIGQGEELEPARKKALQLGIKQDNIFIEDLREEFVRDFVFPMFRANTIYEGEYLLGTSIARPLIAKRQIEIARATGAQAVSHGATGKGNDQVRFELGYYALEPGIKVIAPWREWDLLSREKLLAYAEKAGIPIEMKHKQGGAPYSMDANLLHISFEGRHLEDPKAEAEADMWRWTVSPEQAPDQAEYIDIEYEHGDPVAINGKRLSAAEMLTELNRLGGKHGIGRLDLVENRYVGMKSRGCYETPGGTIMLKAHRGIESITLDREVAHLKDDLMARYASLIYNGYWWSPERRAIQVLIDHTQEKVNGWVRVKLYKGSVSVVARDSKETLFDKTIATFDDDGGAYNQADAGGFIKLNALRMRIAENARRQRG
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOCS1_RAT
Sequence: MVARNQVAADNAISPASEPRRRPEPSSSSSSSSPAAPRRPRPCPVVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI
What is the function of this protein?
Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF).  Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway.  Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity.  In vitro, suppresses Tec protein-tyrosine activity.  Regulates IFN-gamma (IFNG)-mediated sensory neuron survival.  Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
Suppressor of cytokine signaling 1, SOCS-1.
What is the protein family that this protein belongs to?
Belongs to the SOCS1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Protein: PURO_METS3
Sequence: MYTGRILSIGMNCEGKPFVAYRVSSRSFPNRQCLKFDNRASIVPKEGFEKDIFENTYITYNCIRIVKDMAIVSNGSHTDVIADKIALGMNIKDAIAYSLLTLDYEKDDYHTPRIAGVVTSTNKKDDYVCYVGIANDEKLLVDKIPYGEAVFISTYGSQFYDPVDFDAKTADDAAKFIFDGGIFANYKKAVTAGAAVFDGEWNIGNFNP
What is the function of this protein?
Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.
What are the official names of this protein?
IMP cyclohydrolase, IMP synthase, Inosinicase.
What is the protein family that this protein belongs to?
Belongs to the archaeal IMP cyclohydrolase family.