PharMolix/UniProtQA huggingface dataset:
Protein: ILVD_SYNFM
Sequence: MRSDLMKKGVEKAPHRSLFKAMGYTQTELDRPLIGVANSANEIIPGHIHLDKVAEAVKAGIRLAGGTPIEFSTIGVCDGIAMNHAGMRYSLASRELIADSVEIMSMAHPFDGLVAVPNCDKIIPGMLMAMLRLDIPAILISGGPMLAGRAGHKQVDLVSVFEAVGSFKAGTITMEELEQLEDYACPGCGSCAGMFTANSMNCLSEALGLALPGNGTIPAVTGARMRLAKLAGMRIVELIKADIRPRQIATQKAFENAITVDMALGCSTNTVLHVPAIAREAGIDLDLGLFNTLSSRTPHLCSLRPGGPHFLENLDQAGGVQAVMKELLARDLIHRDAMTVTGLTVGKNLESSKNTDPTVIRPISDPYHNEGGIAILYGNLAPEGAVVKQSAVAPEMLQRTCRARVFESETDAAGGILDGKIKPGDVVVIRYEGPKGGPGMQEMLTPTAAIIGMGLGKDVALITDGRFSGGTQGAAIGHVSPEAAVGGPIALIEEGDEILVDILNKRLELMVDDATLKARRDKWKAPAPRMTQGYLARYAHMVTSGSTGAVLRTEQDK
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: TCPC_CLAP2
Sequence: MVFKMVMLKDVFPILVFLVALRLLKSQIAQWMIESIVTKLLQALNPVHDSLGKGISGPRWQYLNGQTLDKFLDGREKVQEWQKYGPVYRIWAGTTPEIVITKPEDVRAFHVDSSRHNKARSSNAGWLFHQLLGECMGLISGTRWIKVRSEFEPAFSHSAITMKAAEVSNDAQCYVNKLEKSRSSSFTVQAAEAVARFPFFCTATHLYGELSEEERNELWELGQRNLKMMGHVLSGGLFRFPIARWLYRSAVQDLESFLCDWASFNERIYKKKVGCGAKTPIVSAWKKVIDGDLTREEAIHTLSEILFANLDVATGNLSWLVIYLAANEDIQRQVVEEISQHRHELDHYCARKDTLLAYCVLETLRLRPFTAFSIPESSPNQKVLHGFTVPGNTSVVVNTLAINYNAAFWGDKAEVFSPNRFHSINRLALRYNLFTFGMGTRKCLGSHFAEMMMKYFAMHLLNRFSLHIPVEKDRSKAQTEDTSMSTWVPISDKEVALQKRTMGLF
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) lacking the reactive thiol group important for toxicity (PubMed:27390873).  Firstly, L-tyrosine is prenylated by tcpD, before undergoing condensation with L-glycine in a reaction catalyzed by the NRPS tcpP leading to the diketopiperazine (DKP) backbone (PubMed:27390873).  Afterwards the alpha-carbon of tyrosine is oxidized by the cytochrome P450 tcpC to form a hydroxyl group (PubMed:27390873).  However, in contrast other ETP biosynthesis pathways studied so far, tcpC is not able to bishydroxylate the DKP at both alpha-carbon positions, but hydroxylates the alpha-carbon of the tyrosine part and the nitrogen of the glycine part (PubMed:27390873).  The next steps involve an alpha,beta-elimination reaction catalyzed by tcpI, a methylation by the methyltransferase tcpN the action of the four enzyme cascade tcpG/K/J/I (PubMed:27390873).  Due to a dysfunctional cytochrome P450 monooxygenase tcpC, the pathway leads to the biosynthesis of probable non-toxic metabolites lacking the reactive thiol group (PubMed:27390873).
What are the official names of this protein?
Cytochrome P450 monooxygenase tcpC, Thioclapurine biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: YDIB_SHIBS
Sequence: MDVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPFTYMAFEVDNDSFPGAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIKGKTMVLLGAGGASTAIGAQGAIEGLKEIKLFNRRDEFFDKALAFAQRVNENTDCVVTVTDLADQQAFAEALASADILTNGTKVGMKPLENESLVNDISLLHPGLLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFTLWTGKDFPLEYVKQVMGFGA
What is the function of this protein?
The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate.  Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively.  It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.
What are the official names of this protein?
Quinate/shikimate dehydrogenase, NAD-dependent shikimate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: CCR9_MOUSE
Sequence: MMPTELTSLIPGMFDDFSYDSTASTDDYMNLNFSSFFCKKNNVRQFASHFLPPLYWLVFIVGTLGNSLVILVYWYCTRVKTMTDMFLLNLAIADLLFLATLPFWAIAAAGQWMFQTFMCKVVNSMYKMNFYSCVLLIMCISVDRYIAIVQAMKAQVWRQKRLLYSKMVCITIWVMAAVLCTPEILYSQVSGESGIATCTMVYPKDKNAKLKSAVLILKVTLGFFLPFMVMAFCYTIIIHTLVQAKKSSKHKALKVTITVLTVFIMSQFPYNSILVVQAVDAYAMFISNCTISTNIDICFQVTQTIAFFHSCLNPVLYVFVGERFRRDLVKTLKNLGCISQAQWVSFTRREGSLKLSSMLLETTSGALSL
What is the function of this protein?
Receptor for chemokine SCYA25/TECK.  Subsequently transduces a signal by increasing the intracellular calcium ions level.
What are the official names of this protein?
C-C chemokine receptor type 9, C-C CKR-9, CC-CKR-9, CCR-9, Chemokine C-C receptor 10.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COBL3_ORYSJ
Sequence: MAVGGAGSSRSVAPCCCCAVLLAAALLFSAPATTEAYDALDPNGNITIKWDVMSWTPDGYVAVVTMFNYQQFRHIQAPGWQLGWTWAKKEVIWSMVGAQTTEQGDCSKFKGGTPHCCKKDPTVVDLLPGTPYNMQIANCCKAGVINTFNQDPSNAASSFQISVGLAGTTNKTVKLPKNFTLKAPGPGYTCGRAMIVRPTKFFTGDGRRATQALMTWNVTCTYSQFLAQKTPSCCVSLSSFYNDTIVNCPTCSCGCQNNGTSPGSCVNENSPYLQSAIDGPGKWTGQPLVQCTSHMCPIRIHWHVKLNYKEYWRVKITITNFNYRMNYTQWNLVAQHPNFNNITQLFSFNYKPLTPYGSKINDTAMFWGVKFYNDLLMQAGPLGNAQSELLLRKDSKDFTFDKGWAFPHRVYFNGDNCVMPPPDAYPWLPNASPLTKQPLTLSVLVFSIVLATLLAYA
What is the function of this protein?
Involved in determining the orientation of cell expansion, probably by playing an important role in cellulose deposition.  May act by recruiting cellulose synthesizing complexes to discrete positions on the cell surface (By similarity).
What are the official names of this protein?
COBRA-like protein 3, Protein BRITTLE CULM1-like 4.
What is the protein family that this protein belongs to?
Belongs to the COBRA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: PLPP7_RAT
Sequence: MPVSQSRARARDRNNVLNRAEFLSLNQPPKGTQEPRSSGRKASGPSTQPPPSSDGARERRQSQQLPEEDCMQLNPSFKGIAFNSLLAIDICMSKRLGVCAGRAASWASARSMVKLIGITSHGIPWIGGTILCLVRSSTLAGQEVLMNLLLALLLDIMTVAGVQKLIKRRGPYETSPGLLDYLTMDIYAFPAGHASRAAMVSKFFLSHLVLAVPLRVLLVLWAFCVGLSRVMIGRHHITDVISGFIIGYFQFRLVELVWMSSNTCQMLISAW
What is the function of this protein?
Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling.  Has no detectable enzymatic activity (By similarity).
What are the official names of this protein?
Inactive phospholipid phosphatase 7, Phosphatidic acid phosphatase type 2 domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm.
Protein: ARGR_CALS8
Sequence: MKSERQQKILEIIQSEDIETQEELVEKLRELGYDVTQATVSRDIKELRLTKVLTETGKYKYAVLSGPEANITEKLIKVFSESIIKYDTADNLVIIKTITGAAQGAAAAIDSLNWPEVIGTIAGDDTIFIATKGNAAAEKIVERIKAILSQGD
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHEB2_AZOBR
Sequence: MSDGFGRPPPPAPAGHPTGAAGGDPVRVMVVDDSAVIRGLLTRALEGDTEIRVVASVGDGQMAVNALQRNSLDVIVLDIEMPVMDGLTAIPKLLAVAPQVKIIMASTLTLRGADISMRCLSAGAADYIPKPTSTREIGGADAFKRELVSKVKALGAAARRAGSRTRGELRPLNPVPAAFLKREPPPVTLRPAPAVGSVGQVKPDVIAIGSSTGGPQALFEVLAHLKTGVTQPILITQHMPATFTTILAEHITRQCGMNAQEAKDGEPVVPGRCYIAPGDFHMLVTQRAGANVISLTKDPPENFCRPAVDPMMRSILRAFGGRKVLACILTGMGQDGLKGCTEVVNAGGTLIAQDEASSVVWGMPGAVAQAGICSAVLPLKEIGPYIRKFASRAA
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFRP5_HUMAN
Sequence: MRAAAAGGGVRTAALALLLGALHWAPARCEEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH
What is the function of this protein?
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts.  They have a role in regulating cell growth and differentiation in specific cell types.  SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.
What are the official names of this protein?
Secreted frizzled-related protein 5, sFRP-5, Frizzled-related protein 1b, FRP-1b, Secreted apoptosis-related protein 3, SARP-3.
What is the protein family that this protein belongs to?
Belongs to the secreted frizzled-related protein (sFRP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLGA_FRATO
Sequence: MRVLHVCSELYPILKTGGLADVTAALPPALAGFGVDSRVLVPGFPAFINAIKDKQLLINIPSRFGAEEINIFLAKIPNTKIDIYVIDAPSLFARPGNPYADSSNQAYADNYLRFALLGWVAARISEGLDAKWKPEIVHSHDWHAGLVPAYIKASELASGKKAVKTVFTVHNLAYQGLFPMSVFTELDLPGIFLSMNGLEFYGQVSFMKAGLYFADKITTVSPTYAKEIQIYEQGCGLEGLLADRHNDLYGVLNGVDPQIWNPKKDSLIATNYSSTTVATGKAKCKLALQQMMGLAEKEDALLFGIVTRLTEQKGLNLLIEAIGEITSRGGQIVLLGSGDKALEEVFLAAAKKYSKSIAVQIGYDEEQAHRIIAGSDVIMVPSRFEPCGLTQLYGLTYGTLPLVHKVGGLADTIIDSSLENLADGTATGFVFDEFSVESLTLAIRRAFALYNRKTDWKKVRKTAMQQQVTWDSSAEKIYQIYKNLVIENN
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: METE_PECAS
Sequence: MAIVNHTLGFPRVGLRRELKKAQESYWAGNATQEELLTVGRELRARHWQQQKDAGVDLLPVGDFAWYDHVLTTSLLLGNVPARHQNEDGSVDLDTLFRIGRGRAPTGQPAAAAEMTKWFNTNYHYMVPEFTKGQQFKLTWTQLLDEVDEALALGHKVKPVLLGPVTYLWLGKVKGEQFDRLSLLQDILPVYQQVLAELTKRGIEWVQIDEPALALELSQEWLAAFKPAYDALQGQVKLLLTTYFDSVSQNLETIKALPVQGLHIDLVHGKDDAATLSAQLPANWVLSLGVINGRNVWRADLSNWFERLQPLVGTRDLWLGSSCSLLHSPIDLSVEVRLDDEVKSWFAFAIQKCAELSLLSQALNSGNGQALEAYSAPIRARRTSTRVNNVAVAQRLAAITAQDSQRQNVYSVRADAQRERFNLPAWPTTTIGSFPQTTEIRGLRLDFKQGRLDGNNYRTGIAEHIKQAVAEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVIIGDVSRPEAITVEWAKYAQSLTDKPMKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLHRSDWDAYLAWAVDAFRLNAAVAKDDTQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEEFEYPNEIGPGVYDIHSPNVPSVEWMEALLKKAAQRIPAERLWVNPDCGLKTRGWPETRQALANMVQAAQRLRETQ
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: TRUA_RICPR
Sequence: MYRYKITIEYLGTHFAGWQRQAGVLSVQQILEEAIYKFSSEQVTLFGSGRTDAGVHAIGQVAHFDLSKYLEPYKIIKAINYFVRPYDVGVWNCELVSNNFHARFSAISRHYIYRIINRTYPSVIDFNRAWWISSPLDILAMQKAAAYLLGKHDFTSFRSSSCQSKSPIKTLTEINIIKEYEEIKLYISAPSFLHYMVRNIVGSLVLVGKNIWQAEQIKNVLDARDRKIAGPTAPAFGLYFIKAEY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: FPG_SHELP
Sequence: MPELPEVEVTRQGISPHLLDQQVTGLTVRNASLRWPVPEVAQQIVGQTIRGIRRRAKYLLLDTDAGTTIVHLGMSGSLRILPKSTPVEKHDHIDLELASGKVLRFNDPRRFGAWLWCELPEAAHPLLAKLGPEPLQSGFNVDYLAKALEGKKKAVKLCLMDNHIVVGVGNIYANEALFAAGIHPQTEAGRIDRERLTVLVAEVKQILAQAIKQGGTTLKDFTNADGKPGYFAQKLHVYGRGGETCTQCGNLLSEIKLGQRATVFCGLCQPR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: DIDO1_HUMAN
Sequence: MDDKGDPSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEADPLEPPPPQQQLGLSLRRSGRQPKRTERVEQFLTIARRRGRRSMPVSLEDSGEPTSCPATDAETASEGSVESASETRSGPQSASTAVKERPASSEKVKGGDDHDDTSDSDSDGLTLKELQNRLRRKREQEPTERPLKGIQSRLRKKRREEGPAETVGSEASDTVEGVLPSKQEPENDQGVVSQAGKDDRESKLEGKAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETHSETADQQEAKWRPGDADGTDCTSIGTIEQKSSEDQGIKGRIEKAANPSGKKKLKIFQPVIEAPGASKCIGPGCCHVAQPDSVYCSNDCILKHAAATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGIKISSVHKRPAPEKKETTVKKAVVVPARSEALGKEAACESSTPSWASDHNYNAVKPEKTAAPSPSLLYKSTKEDRRSEEKAAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPWLSATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPSVPMASPAPGRLGAMSAAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWKERPARSVMESRTKLHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDSSAPDPAPDSADEVMPEAVPEVASEPGLESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPCPASCGSGVVTTVTVSGRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILAKPSSSPDPRYLSVPPSPNISTSESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGCFDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAQDPVPSKLLPFEGPGLESPRPNIILGLVICQKIKRPANSGELDKMDEKRTRLQPEEADVPAYPKVATVPQSEKKPSKYPLCSADAAVSTTPPGSPPPPPPLPEPPVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTASPLEHILQTLFGKKKSFDPSAREPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFSKDKALEEEEDDRPYDPEEEYDPERAFDTQLVERGRRHEVERAPEAAAAEREEVAYDPEDETILEEAKVTVDDLPNRMCADVRRNSVERPAEPVAGAATPSLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMSPPPKSSLPKAELFQQEQQSADKPASLPPASQASNHRDPRQARRLATETGEGEGEPLSRLSARGAQGALPERDASRGGLVGQAPMPVPEEKEPASSPWASGEKPPAGSEQDGWKAEPGEGTRPATVGDSSARPARRVLLPTPPCGALQPGFPLQHDGERDPFTCPGFASQDKALGSAQYEDPRNLHSAGRSSSPAGETEGDREPQARPGEGTAPLPPPGQKVGGSQPPFQGQREPGPHALGMSGLHGPNFPGPRGPAPPFPEENIASNDGPRGPPPARFGAQKGPIPSLFSGQHGPPPYGDSRGPSPSYLGGPRGVAPSQFEERKDPHGEKREFQDAPYNEVTGAPAQFEGTEQAPFLGSRGGAPFQFGGQRRPLLSQLKGPRGGPPPSQFGGQRGPPPGHFVGPRGPHPSQFETARGPHPNQFEGPRGQAPNFMPGPRGIQPQQFEDQRVHSPPRFTNQRAPAPLQFGGLRGSAPFSEKNEQTPSRFHFQGQAPQVMKPGPRPLLELPSHPPQHRKDRWEEAGPPSALSSSAPGQGPEADGQWASADFREGKGHEYRNQTFEGRQRERFDVGPKEKPLEEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDSSRDWDRNRERSANRDREREADRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDRKDRSKSKESARDPKPEASRASDAGTASQA
What is the function of this protein?
Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.
What are the official names of this protein?
Death-inducer obliterator 1, DIO-1, hDido1, Death-associated transcription factor 1, DATF-1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis.
Protein: EPO_SPAGO
Sequence: MGVPDCLALPLLVTFLLLSLGLPVLGAPPRLICDSRVLERYILEAKEAENITMGCAEGPRFNENFTVPDTKVNFYAWKTMGVEEQAVEVWQGLSLLFEAILQAQAVLANSSQPSEMLQLHVDKAISGLRSLTSLLRALGAQKEAISPPDTTQVIPLRRFTVDTFCKLFRIYSNFLRGKLKLYTGEACRRGDR
What is the function of this protein?
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass.  Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
What are the official names of this protein?
Erythropoietin.
What is the protein family that this protein belongs to?
Belongs to the EPO/TPO family.
What are the subcellular locations of this protein?
Secreted.
Protein: UL25_ALTSL
Sequence: MIRNDTMLKGQFVLKKTQIALSAALMGSVLLTGCVTQKSNTESNGPKDTQVSYVEYFADNAVGNPLAIVQHPAAIHKNGITYVSYQGPKEDPFVATYNHSTKEWSGPFKAGTSELGRRDGGKKFDNHGKPTMLIDDEGYVHIFYGGHGGHSSNGKNPLGNTHFGANKHAVSKKPYDITQWEDLDNITPFGTYNQVVKMDNGDIYLFFRHGAHRSDWVYQKSVDNGRTFSSPVSFLKHKRRTDIEAVDSWYAWVGKGEGDNLIVSYDYHVCWDGGAGINGRGHTTERHDVYFMNFNTKTNQWSNVEGESLALPVTKEVADDKTLAMKTGALWTFNGTSHLDNEGHPHIAINAGVDRGAKTGGPKQTRHVWWDGKKWLGGNNIIEGYQGVSRGDFRVTDPSDIRYLVTYEKEGDAVLSWWDSDEDGNAFSEGSTVLRKNNATFAISALIENAHPEAQMLVAEKESDENIKIYLVGEDGPVPRALSNL
What is the function of this protein?
Ulvan lyase involved in ulvan degradation.  Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall.  It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl).  Ulvan lyase catalyzes the endolytic cleavage of the glycosidic bond between Rha3S and the uronic acids GlcA or IduA, producing oligosaccharides that have unsaturated 4-deoxy-L-threo-hex-4-enopyranosiduronic acid (deltaUA) at the non-reducing end.  This results eventually in the degradation of the ulvan polysaccharide into deltaUA-Rha3S disaccharides and deltaUA-Rha3S-Xyl-Rha3S tetrasaccharides.
What are the official names of this protein?
Ulvan lyase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 25 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RL11_STAAC
Sequence: MAKKVDKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNARTQDQAGLIIPVEISVYEDRSFTFITKTPPAPVLLKKAAGIEKGSGEPNKTKVATVTKNQVREIANSKMQDLNAADEEAAMRIIEGTARSMGIVVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: YVAL_VACCC
Sequence: MFNFCSMTSLSAVSVHIRNSPSQNTESSIIIANRLLDLAVCIIFNMFNISFRFPFTGIDRSIFSASEMEMLKLQKCVMLARPNIGTCL
What are the official names of this protein?
Uncharacterized 9.9 kDa protein.
Protein: LPXA_NEIMF
Sequence: MTLIHPTAVIDPKAELDSSVKVGAYTVIGPNVQIGANTEIGPHAVINGHTSIGENNRIFQFASLGEIPQDKKYRDEPTKLIIGNGNTIREFTTFNLGTVTGIGETRIGDDNWIMAYCHLAHDCVVGNHTIFANNASLAGHVTIGDYVVLGGYTLVFQFCRIGDYAMTAFAAGVHKDVPPYFMASGYRAEPAGLNSEGMRRNGFTAEQISAVKDVYKTLYHRGIPFEEAKADILRHAETQAELAVFRDFFAQSARGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANP2_ANALU
Sequence: MKSAILTGLLFVLLCVDHMSSASQSVVATQLIPINTALTPIMMKGQVVNPAGIPFAEMSQIVGKQVNRAVAKDETLMPNMVKTYRAAK
What is the function of this protein?
Contributes to protect fish blood from freezing at subzero sea water temperatures.  Lowers the blood freezing point.  Binds to nascent ice crystals and prevents further growth (By similarity).
What are the official names of this protein?
Type-3 ice-structuring protein 1.5, Antifreeze protein type III, ISP 3.
What is the protein family that this protein belongs to?
Belongs to the type-III AFP family.
What are the subcellular locations of this protein?
Secreted.
Protein: VATB_PYRCJ
Sequence: MLTPVVSYSTVREVKGPLLVIERTRGVSYGEIGEVVGPDGEPRKVQVIEVATDYAVAQVLGGTLGLPSKGSTVRFYGKTLKIPVSEQLIGRILDGKGQPRDHMPLPPPEDFRDVNGEPLNPYSREYPEEPIETGISAIDGLYTLVRGQKLPIFSGTGLPHNMMAAQVVRQSTVRGSGEEFAVVFVGIGIKTEEALFFMDEFRKTGALRRAVAVINLASDPVAERILAPRVGLTIAEYLAWQLGYHVLVVMTDMTNYCEGLRELSSGKGELPGRRGYPGYMYTDLATIYERAGKAHGKKGSVTQFPILTMPNDDITHPIPDLTGYITEGQLVLSRAMWGKGIYPPFDVIMSLSRLAKDAIGEGKTREDHKDVANTLIAAYSKALELRNLATLVGERNLGWRERRYLRFADAFEQKFIKQGYYERRSFEETLDIGWDVLSILPEDELTNARPQITQKFYRRHIFESVAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: TPS1_APHAV
Sequence: MSHGTKYRDALLFSLTLYDVNTGKSRLKELYAAVPGIRKSLLGVHAKRFGEQYHHLQRRRSVSSRGGSLRGSMDSLNDSGQNGAEDVIGVEDEEEAQKFRGKRTSISLDPAAAGEVMFTIEDGACFPSGGLANTHFQQRVINVSNAPPVSLKREKSGEWEIKQGSGGLVSCVDPIMSVNQENMWLANLGMNIDKKKMLRSTELLNVTDDSAPLAPATNTLGLPLMRQALADVLFHVIADDDIKEQNEDEQSRNVRWGHSSVEAGGVAPSQPWEEMSLLGVLNQYNRSNYKLNPVVVQEQDYNVYYGGISNGLLWPALHNLPEYIVADYDDPKVLYEHWCAYVRVNYQFAIDAVRNSRPQDFIWIHDYHLMLTGMIMQSLDSSLEIGFFLHIPFLPPDNFFTKYRLCAFPIMRGLLRFTKVGFQTHRDRAKFVELVGIHLPTARVTYDEKMDIHTVTYQGWSCSLGVFPVSIKNEDFLKVAQSAETIKKADDIRKEILGETPVDSARLLFSVERFDYTKGIKEKLLAYRRYFERHPDRIGKDVLYQVAVTNRRSVDTYRMYQDECIQMAEDINREFATDEYPNWKPLIFRTDGLQRADLVAHYLAMDVGVVTPKKDGMNLVAKEMLVCNPSAGLVLSTGAGSEIQFTMAGLHPDDGDKCYHRVVDVYDADHYADAFYEAAVEPEGERAAHGQRLNEFIMNNDIERWSTAFLDPGWSHLVIRQSEIKDLDDFYSLMMRTRDVRRQIVERVLKGIPIRSHFSISLSNTKESLLLACQPGTRTLHLKPSLEEDEQTEPAHFDIANELDEFEKDLNFMKFIQSDDVYNVEQFINSLQEYHPVSADKFRDEVIELGDVLTEADHFNFFFTDRDGTLKSYSCSYPASIQPAYSGVIQAQFARRCAQTCAIVTTAPLMRIGVLDVSTIPEGYYYFGASAGREWFIDPANKFKDQSIPEEDLELLERVFAAISDLLEEPKFKHFTWVGSGLQKHYGHITIAHQDAFNSVPRHQVRAIDQKIKDIIHRIDPDQHTLKVKETETDIKIFLKSESGEIFDKGQGIRLLVEHMKCDISNGTILVCGDSSTDLPMLQACLEANPSGVYTVWVTRSDELKTTVRELCERFGNKNFVFVSCPEVLLGGMAQATIREISIGRPGPRASHDSE
What is the function of this protein?
Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.
What are the official names of this protein?
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1, Trehalose-6-phosphate synthase 1, UDP-glucose-glucosephosphate glucosyltransferase 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.
Protein: RSMA_METST
Sequence: MSNTKEILEKYNIKLDTNKSQNYLIDDNKLNIILENADIQDNETILEIGAGIGTLTLPMAKKAKKVIAIEKDPIIVDILKQQIIKEKLTNIEIIKDDALKVDFPKFDKVVSNLPYQISSPVTFKLLEYPFKKAILMYQLEFAKRMQAKPDTHEYSRLSVALSYRADTKIIDTLPPEAFIPKPKIKSAVIELIPKNNKPIDKLLDNTIRALFQHRNKKAKKALIQSAHELGVDKKVLKQKLSNVTNDLFEEKVFKLTPTQIKEISLILEGNL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Probable ribosomal RNA small subunit methyltransferase A, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.